id	sid	tid	token	lemma	pos
cord-016523-pznw2ciu	1	1	key	key	NN
cord-016523-pznw2ciu	1	2	:	:	:
cord-016523-pznw2ciu	2	1	cord-016523-pznw2ciu	cord-016523-pznw2ciu	JJ
cord-016523-pznw2ciu	2	2	authors	author	NNS
cord-016523-pznw2ciu	2	3	:	:	:
cord-016523-pznw2ciu	2	4	Fouqué	Fouqué	NNP
cord-016523-pznw2ciu	2	5	,	,	,
cord-016523-pznw2ciu	2	6	Amélie	Amélie	NNP
cord-016523-pznw2ciu	2	7	;	;	:
cord-016523-pznw2ciu	2	8	Legembre	Legembre	NNP
cord-016523-pznw2ciu	2	9	,	,	,
cord-016523-pznw2ciu	2	10	Patrick	Patrick	NNP
cord-016523-pznw2ciu	3	1	title	title	NN
cord-016523-pznw2ciu	3	2	:	:	:
cord-016523-pznw2ciu	3	3	The	the	DT
cord-016523-pznw2ciu	3	4	CD95	CD95	NNP
cord-016523-pznw2ciu	3	5	/	/	SYM
cord-016523-pznw2ciu	3	6	CD95L	cd95l	NN
cord-016523-pznw2ciu	4	1	Signaling	Signaling	NNP
cord-016523-pznw2ciu	4	2	Pathway	Pathway	NNP
cord-016523-pznw2ciu	4	3	:	:	:
cord-016523-pznw2ciu	5	1	A	a	DT
cord-016523-pznw2ciu	5	2	Role	role	NN
cord-016523-pznw2ciu	5	3	in	in	IN
cord-016523-pznw2ciu	5	4	Carcinogenesis	carcinogenesis	NN
cord-016523-pznw2ciu	5	5	date	date	NN
cord-016523-pznw2ciu	5	6	:	:	:
cord-016523-pznw2ciu	5	7	2014	2014	CD
cord-016523-pznw2ciu	5	8	-	-	HYPH
cord-016523-pznw2ciu	5	9	08	08	CD
cord-016523-pznw2ciu	5	10	-	-	SYM
cord-016523-pznw2ciu	5	11	29	29	CD
cord-016523-pznw2ciu	5	12	journal	journal	NN
cord-016523-pznw2ciu	5	13	:	:	:
cord-016523-pznw2ciu	6	1	Cancer	Cancer	NNP
cord-016523-pznw2ciu	6	2	Immunology	Immunology	NNP
cord-016523-pznw2ciu	6	3	DOI	doi	NN
cord-016523-pznw2ciu	6	4	:	:	:
cord-016523-pznw2ciu	7	1	10.1007/978	10.1007/978	LS
cord-016523-pznw2ciu	7	2	-	-	SYM
cord-016523-pznw2ciu	7	3	3	3	CD
cord-016523-pznw2ciu	7	4	-	-	HYPH
cord-016523-pznw2ciu	7	5	662	662	CD
cord-016523-pznw2ciu	7	6	-	-	HYPH
cord-016523-pznw2ciu	7	7	44006	44006	CD
cord-016523-pznw2ciu	7	8	-	-	SYM
cord-016523-pznw2ciu	7	9	3_9	3_9	CD
cord-016523-pznw2ciu	7	10	sha	sha	NNP
cord-016523-pznw2ciu	7	11	:	:	:
cord-016523-pznw2ciu	7	12	6ba198a8a943f8a7b67de6050228f003ba419fd0	6ba198a8a943f8a7b67de6050228f003ba419fd0	CD
cord-016523-pznw2ciu	7	13	doc_id	doc_id	CD
cord-016523-pznw2ciu	7	14	:	:	:
cord-016523-pznw2ciu	7	15	16523	16523	CD
cord-016523-pznw2ciu	7	16	cord_uid	cord_uid	NNS
cord-016523-pznw2ciu	7	17	:	:	:
cord-016523-pznw2ciu	8	1	pznw2ciu	pznw2ciu	NFP
cord-016523-pznw2ciu	8	2	Apoptosis	apoptosis	NN
cord-016523-pznw2ciu	8	3	is	be	VBZ
cord-016523-pznw2ciu	8	4	a	a	DT
cord-016523-pznw2ciu	8	5	fundamental	fundamental	JJ
cord-016523-pznw2ciu	8	6	process	process	NN
cord-016523-pznw2ciu	8	7	contributing	contribute	VBG
cord-016523-pznw2ciu	8	8	to	to	IN
cord-016523-pznw2ciu	8	9	tissue	tissue	NN
cord-016523-pznw2ciu	8	10	homeostasis	homeostasis	NN
cord-016523-pznw2ciu	8	11	,	,	,
cord-016523-pznw2ciu	8	12	immune	immune	JJ
cord-016523-pznw2ciu	8	13	response	response	NN
cord-016523-pznw2ciu	8	14	,	,	,
cord-016523-pznw2ciu	8	15	and	and	CC
cord-016523-pznw2ciu	8	16	development	development	NN
cord-016523-pznw2ciu	8	17	.	.	.
cord-016523-pznw2ciu	9	1	CD95	CD95	NNP
cord-016523-pznw2ciu	9	2	,	,	,
cord-016523-pznw2ciu	9	3	also	also	RB
cord-016523-pznw2ciu	9	4	called	call	VBN
cord-016523-pznw2ciu	9	5	Fas	Fas	NNP
cord-016523-pznw2ciu	9	6	,	,	,
cord-016523-pznw2ciu	9	7	is	be	VBZ
cord-016523-pznw2ciu	9	8	a	a	DT
cord-016523-pznw2ciu	9	9	member	member	NN
cord-016523-pznw2ciu	9	10	of	of	IN
cord-016523-pznw2ciu	9	11	the	the	DT
cord-016523-pznw2ciu	9	12	tumor	tumor	NN
cord-016523-pznw2ciu	9	13	necrosis	necrosis	NN
cord-016523-pznw2ciu	9	14	factor	factor	NN
cord-016523-pznw2ciu	9	15	receptor	receptor	NN
cord-016523-pznw2ciu	9	16	(	(	-LRB-
cord-016523-pznw2ciu	9	17	TNF	TNF	NNP
cord-016523-pznw2ciu	9	18	-	-	HYPH
cord-016523-pznw2ciu	9	19	R	R	NNP
cord-016523-pznw2ciu	9	20	)	)	-RRB-
cord-016523-pznw2ciu	9	21	superfamily	superfamily	NN
cord-016523-pznw2ciu	9	22	.	.	.
cord-016523-pznw2ciu	10	1	Its	-PRON-	PRP$
cord-016523-pznw2ciu	10	2	ligand	ligand	NN
cord-016523-pznw2ciu	10	3	,	,	,
cord-016523-pznw2ciu	10	4	CD95L	cd95l	NN
cord-016523-pznw2ciu	10	5	,	,	,
cord-016523-pznw2ciu	10	6	was	be	VBD
cord-016523-pznw2ciu	10	7	initially	initially	RB
cord-016523-pznw2ciu	10	8	detected	detect	VBN
cord-016523-pznw2ciu	10	9	at	at	IN
cord-016523-pznw2ciu	10	10	the	the	DT
cord-016523-pznw2ciu	10	11	plasma	plasma	NN
cord-016523-pznw2ciu	10	12	membrane	membrane	NN
cord-016523-pznw2ciu	10	13	of	of	IN
cord-016523-pznw2ciu	10	14	activated	activate	VBN
cord-016523-pznw2ciu	10	15	T	T	NNP
cord-016523-pznw2ciu	10	16	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	10	17	and	and	CC
cord-016523-pznw2ciu	10	18	natural	natural	JJ
cord-016523-pznw2ciu	10	19	killer	killer	NN
cord-016523-pznw2ciu	10	20	(	(	-LRB-
cord-016523-pznw2ciu	10	21	NK	NK	NNP
cord-016523-pznw2ciu	10	22	)	)	-RRB-
cord-016523-pznw2ciu	10	23	cells	cell	NNS
cord-016523-pznw2ciu	10	24	where	where	WRB
cord-016523-pznw2ciu	10	25	it	-PRON-	PRP
cord-016523-pznw2ciu	10	26	contributes	contribute	VBZ
cord-016523-pznw2ciu	10	27	to	to	IN
cord-016523-pznw2ciu	10	28	the	the	DT
cord-016523-pznw2ciu	10	29	elimination	elimination	NN
cord-016523-pznw2ciu	10	30	of	of	IN
cord-016523-pznw2ciu	10	31	transformed	transform	VBN
cord-016523-pznw2ciu	10	32	and	and	CC
cord-016523-pznw2ciu	10	33	infected	infected	JJ
cord-016523-pznw2ciu	10	34	cells	cell	NNS
cord-016523-pznw2ciu	10	35	.	.	.
cord-016523-pznw2ciu	11	1	Given	give	VBN
cord-016523-pznw2ciu	11	2	its	-PRON-	PRP$
cord-016523-pznw2ciu	11	3	implication	implication	NN
cord-016523-pznw2ciu	11	4	in	in	IN
cord-016523-pznw2ciu	11	5	immune	immune	JJ
cord-016523-pznw2ciu	11	6	homeostasis	homeostasis	NN
cord-016523-pznw2ciu	11	7	and	and	CC
cord-016523-pznw2ciu	11	8	immune	immune	JJ
cord-016523-pznw2ciu	11	9	surveillance	surveillance	NN
cord-016523-pznw2ciu	11	10	combined	combine	VBN
cord-016523-pznw2ciu	11	11	with	with	IN
cord-016523-pznw2ciu	11	12	the	the	DT
cord-016523-pznw2ciu	11	13	fact	fact	NN
cord-016523-pznw2ciu	11	14	that	that	IN
cord-016523-pznw2ciu	11	15	various	various	JJ
cord-016523-pznw2ciu	11	16	lineages	lineage	NNS
cord-016523-pznw2ciu	11	17	of	of	IN
cord-016523-pznw2ciu	11	18	malignant	malignant	JJ
cord-016523-pznw2ciu	11	19	cells	cell	NNS
cord-016523-pznw2ciu	11	20	exhibit	exhibit	VBP
cord-016523-pznw2ciu	11	21	loss	loss	NN
cord-016523-pznw2ciu	11	22	-	-	HYPH
cord-016523-pznw2ciu	11	23	of	of	IN
cord-016523-pznw2ciu	11	24	-	-	HYPH
cord-016523-pznw2ciu	11	25	function	function	NN
cord-016523-pznw2ciu	11	26	mutations	mutation	NNS
cord-016523-pznw2ciu	11	27	,	,	,
cord-016523-pznw2ciu	11	28	CD95	CD95	NNP
cord-016523-pznw2ciu	11	29	was	be	VBD
cord-016523-pznw2ciu	11	30	initially	initially	RB
cord-016523-pznw2ciu	11	31	classified	classify	VBN
cord-016523-pznw2ciu	11	32	as	as	IN
cord-016523-pznw2ciu	11	33	a	a	DT
cord-016523-pznw2ciu	11	34	tumor	tumor	NN
cord-016523-pznw2ciu	11	35	suppressor	suppressor	NN
cord-016523-pznw2ciu	11	36	gene	gene	NN
cord-016523-pznw2ciu	11	37	.	.	.
cord-016523-pznw2ciu	12	1	Nonetheless	nonetheless	RB
cord-016523-pznw2ciu	12	2	,	,	,
cord-016523-pznw2ciu	12	3	in	in	IN
cord-016523-pznw2ciu	12	4	different	different	JJ
cord-016523-pznw2ciu	12	5	pathophysiological	pathophysiological	JJ
cord-016523-pznw2ciu	12	6	contexts	context	NNS
cord-016523-pznw2ciu	12	7	,	,	,
cord-016523-pznw2ciu	12	8	this	this	DT
cord-016523-pznw2ciu	12	9	receptor	receptor	NN
cord-016523-pznw2ciu	12	10	is	be	VBZ
cord-016523-pznw2ciu	12	11	able	able	JJ
cord-016523-pznw2ciu	12	12	to	to	TO
cord-016523-pznw2ciu	12	13	transmit	transmit	VB
cord-016523-pznw2ciu	12	14	non	non	JJ
cord-016523-pznw2ciu	12	15	-	-	JJ
cord-016523-pznw2ciu	12	16	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	12	17	signals	signal	NNS
cord-016523-pznw2ciu	12	18	and	and	CC
cord-016523-pznw2ciu	12	19	promote	promote	VB
cord-016523-pznw2ciu	12	20	inflammation	inflammation	NN
cord-016523-pznw2ciu	12	21	and	and	CC
cord-016523-pznw2ciu	12	22	carcinogenesis	carcinogenesis	NN
cord-016523-pznw2ciu	12	23	.	.	.
cord-016523-pznw2ciu	13	1	Although	although	IN
cord-016523-pznw2ciu	13	2	the	the	DT
cord-016523-pznw2ciu	13	3	different	different	JJ
cord-016523-pznw2ciu	13	4	non	non	JJ
cord-016523-pznw2ciu	13	5	-	-	JJ
cord-016523-pznw2ciu	13	6	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	13	7	signaling	signal	VBG
cord-016523-pznw2ciu	13	8	pathways	pathway	NNS
cord-016523-pznw2ciu	13	9	(	(	-LRB-
cord-016523-pznw2ciu	13	10	NF	nf	NN
cord-016523-pznw2ciu	13	11	-	-	HYPH
cord-016523-pznw2ciu	13	12	κB	κB	NNP
cord-016523-pznw2ciu	13	13	,	,	,
cord-016523-pznw2ciu	13	14	MAPK	MAPK	NNP
cord-016523-pznw2ciu	13	15	,	,	,
cord-016523-pznw2ciu	13	16	and	and	CC
cord-016523-pznw2ciu	13	17	PI3	PI3	NNP
cord-016523-pznw2ciu	13	18	K	K	NNP
cord-016523-pznw2ciu	13	19	)	)	-RRB-
cord-016523-pznw2ciu	13	20	triggered	trigger	VBN
cord-016523-pznw2ciu	13	21	by	by	IN
cord-016523-pznw2ciu	13	22	CD95	CD95	NNP
cord-016523-pznw2ciu	13	23	are	be	VBP
cord-016523-pznw2ciu	13	24	known	know	VBN
cord-016523-pznw2ciu	13	25	,	,	,
cord-016523-pznw2ciu	13	26	the	the	DT
cord-016523-pznw2ciu	13	27	initial	initial	JJ
cord-016523-pznw2ciu	13	28	molecular	molecular	JJ
cord-016523-pznw2ciu	13	29	events	event	NNS
cord-016523-pznw2ciu	13	30	leading	lead	VBG
cord-016523-pznw2ciu	13	31	to	to	IN
cord-016523-pznw2ciu	13	32	these	these	DT
cord-016523-pznw2ciu	13	33	signals	signal	NNS
cord-016523-pznw2ciu	13	34	,	,	,
cord-016523-pznw2ciu	13	35	the	the	DT
cord-016523-pznw2ciu	13	36	mechanisms	mechanism	NNS
cord-016523-pznw2ciu	13	37	by	by	IN
cord-016523-pznw2ciu	13	38	which	which	WDT
cord-016523-pznw2ciu	13	39	the	the	DT
cord-016523-pznw2ciu	13	40	receptor	receptor	NN
cord-016523-pznw2ciu	13	41	switches	switch	VBZ
cord-016523-pznw2ciu	13	42	from	from	IN
cord-016523-pznw2ciu	13	43	an	an	DT
cord-016523-pznw2ciu	13	44	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	13	45	function	function	NN
cord-016523-pznw2ciu	13	46	to	to	IN
cord-016523-pznw2ciu	13	47	an	an	DT
cord-016523-pznw2ciu	13	48	inflammatory	inflammatory	JJ
cord-016523-pznw2ciu	13	49	role	role	NN
cord-016523-pznw2ciu	13	50	,	,	,
cord-016523-pznw2ciu	13	51	and	and	CC
cord-016523-pznw2ciu	13	52	,	,	,
cord-016523-pznw2ciu	13	53	more	more	RBR
cord-016523-pznw2ciu	13	54	importantly	importantly	RB
cord-016523-pznw2ciu	13	55	,	,	,
cord-016523-pznw2ciu	13	56	the	the	DT
cord-016523-pznw2ciu	13	57	biological	biological	JJ
cord-016523-pznw2ciu	13	58	functions	function	NNS
cord-016523-pznw2ciu	13	59	of	of	IN
cord-016523-pznw2ciu	13	60	these	these	DT
cord-016523-pznw2ciu	13	61	signals	signal	NNS
cord-016523-pznw2ciu	13	62	remain	remain	VBP
cord-016523-pznw2ciu	13	63	elusive	elusive	JJ
cord-016523-pznw2ciu	13	64	.	.	.
cord-016523-pznw2ciu	14	1	and	and	CC
cord-016523-pznw2ciu	14	2	the	the	DT
cord-016523-pznw2ciu	14	3	loss	loss	NN
cord-016523-pznw2ciu	14	4	of	of	IN
cord-016523-pznw2ciu	14	5	its	-PRON-	PRP$
cord-016523-pznw2ciu	14	6	extracellular	extracellular	JJ
cord-016523-pznw2ciu	14	7	membrane	membrane	NN
cord-016523-pznw2ciu	14	8	integrity	integrity	NN
cord-016523-pznw2ciu	14	9	,	,	,
cord-016523-pznw2ciu	14	10	leading	lead	VBG
cord-016523-pznw2ciu	14	11	to	to	IN
cord-016523-pznw2ciu	14	12	the	the	DT
cord-016523-pznw2ciu	14	13	release	release	NN
cord-016523-pznw2ciu	14	14	of	of	IN
cord-016523-pznw2ciu	14	15	different	different	JJ
cord-016523-pznw2ciu	14	16	apoptogenic	apoptogenic	JJ
cord-016523-pznw2ciu	14	17	factors	factor	NNS
cord-016523-pznw2ciu	14	18	in	in	IN
cord-016523-pznw2ciu	14	19	the	the	DT
cord-016523-pznw2ciu	14	20	cytosol	cytosol	NN
cord-016523-pznw2ciu	14	21	.	.	.
cord-016523-pznw2ciu	15	1	Among	among	IN
cord-016523-pznw2ciu	15	2	them	-PRON-	PRP
cord-016523-pznw2ciu	15	3	,	,	,
cord-016523-pznw2ciu	15	4	cytochrome	cytochrome	NN
cord-016523-pznw2ciu	15	5	c	c	NN
cord-016523-pznw2ciu	15	6	associates	associate	NNS
cord-016523-pznw2ciu	15	7	with	with	IN
cord-016523-pznw2ciu	15	8	the	the	DT
cord-016523-pznw2ciu	15	9	caspase-9/	caspase-9/	NNP
cord-016523-pznw2ciu	15	10	APAF1	apaf1	NN
cord-016523-pznw2ciu	15	11	complex	complex	NN
cord-016523-pznw2ciu	15	12	to	to	TO
cord-016523-pznw2ciu	15	13	form	form	VB
cord-016523-pznw2ciu	15	14	the	the	DT
cord-016523-pznw2ciu	15	15	apoptosome	apoptosome	NN
cord-016523-pznw2ciu	15	16	and	and	CC
cord-016523-pznw2ciu	15	17	trigger	trigger	NN
cord-016523-pznw2ciu	15	18	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	15	19	[	[	-LRB-
cord-016523-pznw2ciu	15	20	6	6	CD
cord-016523-pznw2ciu	15	21	]	]	-RRB-
cord-016523-pznw2ciu	15	22	.	.	.
cord-016523-pznw2ciu	16	1	These	these	DT
cord-016523-pznw2ciu	16	2	two	two	CD
cord-016523-pznw2ciu	16	3	signaling	signal	VBG
cord-016523-pznw2ciu	16	4	pathways	pathway	NNS
cord-016523-pznw2ciu	16	5	share	share	VBP
cord-016523-pznw2ciu	16	6	common	common	JJ
cord-016523-pznw2ciu	16	7	features	feature	NNS
cord-016523-pznw2ciu	16	8	,	,	,
cord-016523-pznw2ciu	16	9	and	and	CC
cord-016523-pznw2ciu	16	10	both	both	DT
cord-016523-pznw2ciu	16	11	require	require	VBP
cord-016523-pznw2ciu	16	12	the	the	DT
cord-016523-pznw2ciu	16	13	aggregation	aggregation	NN
cord-016523-pznw2ciu	16	14	of	of	IN
cord-016523-pznw2ciu	16	15	initiator	initiator	NN
cord-016523-pznw2ciu	16	16	caspases	caspase	NNS
cord-016523-pznw2ciu	16	17	as	as	IN
cord-016523-pznw2ciu	16	18	their	-PRON-	PRP$
cord-016523-pznw2ciu	16	19	preliminary	preliminary	JJ
cord-016523-pznw2ciu	16	20	events	event	NNS
cord-016523-pznw2ciu	16	21	.	.	.
cord-016523-pznw2ciu	17	1	During	during	IN
cord-016523-pznw2ciu	17	2	interactions	interaction	NNS
cord-016523-pznw2ciu	17	3	with	with	IN
cord-016523-pznw2ciu	17	4	respective	respective	JJ
cord-016523-pznw2ciu	17	5	ligands	ligand	NNS
cord-016523-pznw2ciu	17	6	,	,	,
cord-016523-pznw2ciu	17	7	members	member	NNS
cord-016523-pznw2ciu	17	8	of	of	IN
cord-016523-pznw2ciu	17	9	the	the	DT
cord-016523-pznw2ciu	17	10	death	death	NN
cord-016523-pznw2ciu	17	11	receptor	receptor	NN
cord-016523-pznw2ciu	17	12	superfamily	superfamily	NN
cord-016523-pznw2ciu	17	13	recruit	recruit	VBP
cord-016523-pznw2ciu	17	14	adaptor	adaptor	NN
cord-016523-pznw2ciu	17	15	proteins	protein	NNS
cord-016523-pznw2ciu	17	16	such	such	JJ
cord-016523-pznw2ciu	17	17	as	as	IN
cord-016523-pznw2ciu	17	18	Fas	Fas	NNP
cord-016523-pznw2ciu	17	19	-	-	HYPH
cord-016523-pznw2ciu	17	20	associating	associate	VBG
cord-016523-pznw2ciu	17	21	protein	protein	NN
cord-016523-pznw2ciu	17	22	with	with	IN
cord-016523-pznw2ciu	17	23	a	a	DT
cord-016523-pznw2ciu	17	24	death	death	NN
cord-016523-pznw2ciu	17	25	domain	domain	NN
cord-016523-pznw2ciu	17	26	(	(	-LRB-
cord-016523-pznw2ciu	17	27	FADD	FADD	NNP
cord-016523-pznw2ciu	17	28	)	)	-RRB-
cord-016523-pznw2ciu	17	29	[	[	-LRB-
cord-016523-pznw2ciu	17	30	7	7	CD
cord-016523-pznw2ciu	17	31	,	,	,
cord-016523-pznw2ciu	17	32	8	8	CD
cord-016523-pznw2ciu	17	33	]	]	-RRB-
cord-016523-pznw2ciu	17	34	or	or	CC
cord-016523-pznw2ciu	17	35	tumor	tumor	NN
cord-016523-pznw2ciu	17	36	necrosis	necrosis	NN
cord-016523-pznw2ciu	17	37	factor	factor	NN
cord-016523-pznw2ciu	17	38	(	(	-LRB-
cord-016523-pznw2ciu	17	39	TNF	TNF	NNP
cord-016523-pznw2ciu	17	40	)	)	-RRB-
cord-016523-pznw2ciu	17	41	receptor	receptor	NN
cord-016523-pznw2ciu	17	42	1-associated	1-associated	CD
cord-016523-pznw2ciu	17	43	death	death	NN
cord-016523-pznw2ciu	17	44	domain	domain	NN
cord-016523-pznw2ciu	17	45	protein	protein	NN
cord-016523-pznw2ciu	17	46	(	(	-LRB-
cord-016523-pznw2ciu	17	47	TRADD	TRADD	NNP
cord-016523-pznw2ciu	17	48	)	)	-RRB-
cord-016523-pznw2ciu	17	49	[	[	-LRB-
cord-016523-pznw2ciu	17	50	9	9	CD
cord-016523-pznw2ciu	17	51	]	]	-RRB-
cord-016523-pznw2ciu	17	52	,	,	,
cord-016523-pznw2ciu	17	53	resulting	result	VBG
cord-016523-pznw2ciu	17	54	in	in	IN
cord-016523-pznw2ciu	17	55	the	the	DT
cord-016523-pznw2ciu	17	56	aggregation	aggregation	NN
cord-016523-pznw2ciu	17	57	and	and	CC
cord-016523-pznw2ciu	17	58	activation	activation	NN
cord-016523-pznw2ciu	17	59	of	of	IN
cord-016523-pznw2ciu	17	60	the	the	DT
cord-016523-pznw2ciu	17	61	initiator	initiator	NN
cord-016523-pznw2ciu	17	62	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	17	63	and	and	CC
cord-016523-pznw2ciu	17	64	caspase-10	caspase-10	NN
cord-016523-pznw2ciu	17	65	to	to	TO
cord-016523-pznw2ciu	17	66	form	form	VB
cord-016523-pznw2ciu	17	67	the	the	DT
cord-016523-pznw2ciu	17	68	death	death	NN
cord-016523-pznw2ciu	17	69	-	-	HYPH
cord-016523-pznw2ciu	17	70	inducing	induce	VBG
cord-016523-pznw2ciu	17	71	signaling	signal	VBG
cord-016523-pznw2ciu	17	72	complex	complex	NN
cord-016523-pznw2ciu	17	73	(	(	-LRB-
cord-016523-pznw2ciu	17	74	DISC	disc	NN
cord-016523-pznw2ciu	17	75	)	)	-RRB-
cord-016523-pznw2ciu	17	76	[	[	-LRB-
cord-016523-pznw2ciu	17	77	10	10	CD
cord-016523-pznw2ciu	17	78	]	]	-RRB-
cord-016523-pznw2ciu	17	79	.	.	.
cord-016523-pznw2ciu	18	1	In	in	IN
cord-016523-pznw2ciu	18	2	a	a	DT
cord-016523-pznw2ciu	18	3	similar	similar	JJ
cord-016523-pznw2ciu	18	4	manner	manner	NN
cord-016523-pznw2ciu	18	5	,	,	,
cord-016523-pznw2ciu	18	6	release	release	NN
cord-016523-pznw2ciu	18	7	of	of	IN
cord-016523-pznw2ciu	18	8	cytochrome	cytochrome	NN
cord-016523-pznw2ciu	18	9	c	c	NN
cord-016523-pznw2ciu	18	10	and	and	CC
cord-016523-pznw2ciu	18	11	ATP	ATP	NNP
cord-016523-pznw2ciu	18	12	by	by	IN
cord-016523-pznw2ciu	18	13	mitochondria	mitochondrion	NNS
cord-016523-pznw2ciu	18	14	promotes	promote	VBZ
cord-016523-pznw2ciu	18	15	the	the	DT
cord-016523-pznw2ciu	18	16	formation	formation	NN
cord-016523-pznw2ciu	18	17	of	of	IN
cord-016523-pznw2ciu	18	18	the	the	DT
cord-016523-pznw2ciu	18	19	apoptosome	apoptosome	NN
cord-016523-pznw2ciu	18	20	with	with	IN
cord-016523-pznw2ciu	18	21	the	the	DT
cord-016523-pznw2ciu	18	22	cytosolic	cytosolic	JJ
cord-016523-pznw2ciu	18	23	APAF-1	APAF-1	NNP
cord-016523-pznw2ciu	18	24	,	,	,
cord-016523-pznw2ciu	18	25	thereby	thereby	RB
cord-016523-pznw2ciu	18	26	aggregating	aggregate	VBG
cord-016523-pznw2ciu	18	27	and	and	CC
cord-016523-pznw2ciu	18	28	activating	activate	VBG
cord-016523-pznw2ciu	18	29	the	the	DT
cord-016523-pznw2ciu	18	30	initiator	initiator	NN
cord-016523-pznw2ciu	18	31	caspase-9	caspase-9	NNP
cord-016523-pznw2ciu	18	32	,	,	,
cord-016523-pznw2ciu	18	33	which	which	WDT
cord-016523-pznw2ciu	18	34	in	in	IN
cord-016523-pznw2ciu	18	35	turn	turn	NN
cord-016523-pznw2ciu	18	36	cleaves	cleave	VBZ
cord-016523-pznw2ciu	18	37	caspase-3	caspase-3	NNP
cord-016523-pznw2ciu	18	38	[	[	-LRB-
cord-016523-pznw2ciu	18	39	11	11	CD
cord-016523-pznw2ciu	18	40	]	]	-RRB-
cord-016523-pznw2ciu	18	41	.	.	.
cord-016523-pznw2ciu	19	1	It	-PRON-	PRP
cord-016523-pznw2ciu	19	2	should	should	MD
cord-016523-pznw2ciu	19	3	be	be	VB
cord-016523-pznw2ciu	19	4	kept	keep	VBN
cord-016523-pznw2ciu	19	5	in	in	IN
cord-016523-pznw2ciu	19	6	mind	mind	NN
cord-016523-pznw2ciu	19	7	that	that	IN
cord-016523-pznw2ciu	19	8	death	death	NN
cord-016523-pznw2ciu	19	9	receptors	receptor	NNS
cord-016523-pznw2ciu	19	10	CD95	CD95	NNP
cord-016523-pznw2ciu	19	11	[	[	-LRB-
cord-016523-pznw2ciu	19	12	12	12	CD
cord-016523-pznw2ciu	19	13	]	]	-RRB-
cord-016523-pznw2ciu	19	14	,	,	.
cord-016523-pznw2ciu	20	1	TNFR1	tnfr1	XX
cord-016523-pznw2ciu	21	1	[	[	-LRB-
cord-016523-pznw2ciu	21	2	13	13	CD
cord-016523-pznw2ciu	21	3	]	]	-RRB-
cord-016523-pznw2ciu	21	4	,	,	,
cord-016523-pznw2ciu	21	5	DR4	DR4	NNP
cord-016523-pznw2ciu	21	6	[	[	-LRB-
cord-016523-pznw2ciu	21	7	14	14	CD
cord-016523-pznw2ciu	21	8	]	]	-RRB-
cord-016523-pznw2ciu	21	9	,	,	,
cord-016523-pznw2ciu	21	10	DR5	DR5	NNP
cord-016523-pznw2ciu	21	11	[	[	-LRB-
cord-016523-pznw2ciu	21	12	15	15	CD
cord-016523-pznw2ciu	21	13	]	]	-RRB-
cord-016523-pznw2ciu	21	14	,	,	,
cord-016523-pznw2ciu	21	15	and	and	CC
cord-016523-pznw2ciu	21	16	DR6	DR6	NNP
cord-016523-pznw2ciu	21	17	[	[	-LRB-
cord-016523-pznw2ciu	21	18	16	16	CD
cord-016523-pznw2ciu	21	19	]	]	-RRB-
cord-016523-pznw2ciu	21	20	have	have	VBP
cord-016523-pznw2ciu	21	21	been	be	VBN
cord-016523-pznw2ciu	21	22	cloned	clone	VBN
cord-016523-pznw2ciu	21	23	based	base	VBN
cord-016523-pznw2ciu	21	24	on	on	IN
cord-016523-pznw2ciu	21	25	their	-PRON-	PRP$
cord-016523-pznw2ciu	21	26	ability	ability	NN
cord-016523-pznw2ciu	21	27	to	to	TO
cord-016523-pznw2ciu	21	28	elicit	elicit	VB
cord-016523-pznw2ciu	21	29	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	21	30	.	.	.
cord-016523-pznw2ciu	22	1	Although	although	IN
cord-016523-pznw2ciu	22	2	studies	study	NNS
cord-016523-pznw2ciu	22	3	have	have	VBP
cord-016523-pznw2ciu	22	4	revealed	reveal	VBN
cord-016523-pznw2ciu	22	5	the	the	DT
cord-016523-pznw2ciu	22	6	ability	ability	NN
cord-016523-pznw2ciu	22	7	of	of	IN
cord-016523-pznw2ciu	22	8	Fas	Fas	NNP
cord-016523-pznw2ciu	22	9	/	/	SYM
cord-016523-pznw2ciu	22	10	CD95	CD95	NNP
cord-016523-pznw2ciu	22	11	,	,	,
cord-016523-pznw2ciu	22	12	DR4	dr4	NN
cord-016523-pznw2ciu	22	13	,	,	,
cord-016523-pznw2ciu	22	14	and	and	CC
cord-016523-pznw2ciu	22	15	DR5	DR5	NNP
cord-016523-pznw2ciu	22	16	in	in	IN
cord-016523-pznw2ciu	22	17	triggering	trigger	VBG
cord-016523-pznw2ciu	22	18	non	non	JJ
cord-016523-pznw2ciu	22	19	-	-	JJ
cord-016523-pznw2ciu	22	20	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	22	21	signaling	signal	VBG
cord-016523-pznw2ciu	22	22	pathways	pathway	NNS
cord-016523-pznw2ciu	22	23	even	even	RB
cord-016523-pznw2ciu	22	24	immediately	immediately	RB
cord-016523-pznw2ciu	22	25	after	after	IN
cord-016523-pznw2ciu	22	26	their	-PRON-	PRP$
cord-016523-pznw2ciu	22	27	cloning	clone	VBG
cord-016523-pznw2ciu	22	28	[	[	-LRB-
cord-016523-pznw2ciu	22	29	17	17	CD
cord-016523-pznw2ciu	22	30	,	,	,
cord-016523-pznw2ciu	22	31	18	18	CD
cord-016523-pznw2ciu	22	32	]	]	-RRB-
cord-016523-pznw2ciu	22	33	,	,	,
cord-016523-pznw2ciu	22	34	most	most	JJS
cord-016523-pznw2ciu	22	35	,	,	,
cord-016523-pznw2ciu	22	36	if	if	IN
cord-016523-pznw2ciu	22	37	not	not	RB
cord-016523-pznw2ciu	22	38	all	all	DT
cord-016523-pznw2ciu	22	39	,	,	,
cord-016523-pznw2ciu	22	40	studies	study	NNS
cord-016523-pznw2ciu	22	41	have	have	VBP
cord-016523-pznw2ciu	22	42	been	be	VBN
cord-016523-pznw2ciu	22	43	focused	focus	VBN
cord-016523-pznw2ciu	22	44	on	on	IN
cord-016523-pznw2ciu	22	45	characterizing	characterize	VBG
cord-016523-pznw2ciu	22	46	the	the	DT
cord-016523-pznw2ciu	22	47	molecular	molecular	JJ
cord-016523-pznw2ciu	22	48	events	event	NNS
cord-016523-pznw2ciu	22	49	leading	lead	VBG
cord-016523-pznw2ciu	22	50	to	to	IN
cord-016523-pznw2ciu	22	51	cell	cell	NN
cord-016523-pznw2ciu	22	52	death	death	NN
cord-016523-pznw2ciu	22	53	.	.	.
cord-016523-pznw2ciu	23	1	Accordingly	accordingly	RB
cord-016523-pznw2ciu	23	2	,	,	,
cord-016523-pznw2ciu	23	3	several	several	JJ
cord-016523-pznw2ciu	23	4	agonistic	agonistic	JJ
cord-016523-pznw2ciu	23	5	molecules	molecule	NNS
cord-016523-pznw2ciu	23	6	were	be	VBD
cord-016523-pznw2ciu	23	7	developed	develop	VBN
cord-016523-pznw2ciu	23	8	in	in	IN
cord-016523-pznw2ciu	23	9	order	order	NN
cord-016523-pznw2ciu	23	10	to	to	TO
cord-016523-pznw2ciu	23	11	kill	kill	VB
cord-016523-pznw2ciu	23	12	cancer	cancer	NN
cord-016523-pznw2ciu	23	13	cells	cell	NNS
cord-016523-pznw2ciu	23	14	,	,	,
cord-016523-pznw2ciu	23	15	neglecting	neglect	VBG
cord-016523-pznw2ciu	23	16	the	the	DT
cord-016523-pznw2ciu	23	17	impact	impact	NN
cord-016523-pznw2ciu	23	18	of	of	IN
cord-016523-pznw2ciu	23	19	non	non	JJ
cord-016523-pznw2ciu	23	20	-	-	JJ
cord-016523-pznw2ciu	23	21	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	23	22	signals	signal	NNS
cord-016523-pznw2ciu	23	23	in	in	IN
cord-016523-pznw2ciu	23	24	pathophysiological	pathophysiological	JJ
cord-016523-pznw2ciu	23	25	contexts	context	NNS
cord-016523-pznw2ciu	23	26	.	.	.
cord-016523-pznw2ciu	24	1	More	More	JJR
cord-016523-pznw2ciu	24	2	recent	recent	JJ
cord-016523-pznw2ciu	24	3	data	datum	NNS
cord-016523-pznw2ciu	24	4	changed	change	VBD
cord-016523-pznw2ciu	24	5	this	this	DT
cord-016523-pznw2ciu	24	6	vision	vision	NN
cord-016523-pznw2ciu	24	7	by	by	IN
cord-016523-pznw2ciu	24	8	evaluating	evaluate	VBG
cord-016523-pznw2ciu	24	9	the	the	DT
cord-016523-pznw2ciu	24	10	biological	biological	JJ
cord-016523-pznw2ciu	24	11	role	role	NN
cord-016523-pznw2ciu	24	12	of	of	IN
cord-016523-pznw2ciu	24	13	death	death	NN
cord-016523-pznw2ciu	24	14	receptor	receptor	NN
cord-016523-pznw2ciu	24	15	-	-	HYPH
cord-016523-pznw2ciu	24	16	mediated	mediate	VBN
cord-016523-pznw2ciu	24	17	non	non	JJ
cord-016523-pznw2ciu	24	18	-	-	JJ
cord-016523-pznw2ciu	24	19	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	24	20	signaling	signal	VBG
cord-016523-pznw2ciu	24	21	pathways	pathway	NNS
cord-016523-pznw2ciu	24	22	in	in	IN
cord-016523-pznw2ciu	24	23	chronic	chronic	JJ
cord-016523-pznw2ciu	24	24	infl	infl	NNP
cord-016523-pznw2ciu	24	25	ammatory	ammatory	NN
cord-016523-pznw2ciu	24	26	disorders	disorder	NNS
cord-016523-pznw2ciu	24	27	and	and	CC
cord-016523-pznw2ciu	24	28	carcinogenesis	carcinogenesis	NN
cord-016523-pznw2ciu	24	29	.	.	.
cord-016523-pznw2ciu	25	1	In	in	IN
cord-016523-pznw2ciu	25	2	this	this	DT
cord-016523-pznw2ciu	25	3	chapter	chapter	NN
cord-016523-pznw2ciu	25	4	,	,	,
cord-016523-pznw2ciu	25	5	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	25	6	signaling	signal	VBG
cord-016523-pznw2ciu	25	7	pathways	pathway	NNS
cord-016523-pznw2ciu	25	8	induced	induce	VBN
cord-016523-pznw2ciu	25	9	by	by	IN
cord-016523-pznw2ciu	25	10	death	death	NN
cord-016523-pznw2ciu	25	11	receptors	receptor	NNS
cord-016523-pznw2ciu	25	12	are	be	VBP
cord-016523-pznw2ciu	25	13	discussed	discuss	VBN
cord-016523-pznw2ciu	25	14	.	.	.
cord-016523-pznw2ciu	26	1	Moreover	moreover	RB
cord-016523-pznw2ciu	26	2	,	,	,
cord-016523-pznw2ciu	26	3	recent	recent	JJ
cord-016523-pznw2ciu	26	4	evidences	evidence	NNS
cord-016523-pznw2ciu	26	5	pointing	point	VBG
cord-016523-pznw2ciu	26	6	to	to	IN
cord-016523-pznw2ciu	26	7	the	the	DT
cord-016523-pznw2ciu	26	8	nonapoptotic	nonapoptotic	JJ
cord-016523-pznw2ciu	26	9	signals	signal	NNS
cord-016523-pznw2ciu	26	10	transmitted	transmit	VBN
cord-016523-pznw2ciu	26	11	by	by	IN
cord-016523-pznw2ciu	26	12	the	the	DT
cord-016523-pznw2ciu	26	13	same	same	JJ
cord-016523-pznw2ciu	26	14	receptors	receptor	NNS
cord-016523-pznw2ciu	26	15	are	be	VBP
cord-016523-pznw2ciu	26	16	brought	bring	VBN
cord-016523-pznw2ciu	26	17	up	up	RP
cord-016523-pznw2ciu	26	18	,	,	,
cord-016523-pznw2ciu	26	19	which	which	WDT
cord-016523-pznw2ciu	26	20	may	may	MD
cord-016523-pznw2ciu	26	21	imply	imply	VB
cord-016523-pznw2ciu	26	22	their	-PRON-	PRP$
cord-016523-pznw2ciu	26	23	tremendous	tremendous	JJ
cord-016523-pznw2ciu	26	24	impact	impact	NN
cord-016523-pznw2ciu	26	25	on	on	IN
cord-016523-pznw2ciu	26	26	tumor	tumor	NN
cord-016523-pznw2ciu	26	27	progression	progression	NN
cord-016523-pznw2ciu	26	28	and	and	CC
cord-016523-pznw2ciu	26	29	the	the	DT
cord-016523-pznw2ciu	26	30	design	design	NN
cord-016523-pznw2ciu	26	31	of	of	IN
cord-016523-pznw2ciu	26	32	therapeutic	therapeutic	JJ
cord-016523-pznw2ciu	26	33	tools	tool	NNS
cord-016523-pznw2ciu	26	34	.	.	.
cord-016523-pznw2ciu	27	1	Death	death	NN
cord-016523-pznw2ciu	27	2	receptors	receptor	NNS
cord-016523-pznw2ciu	28	1	TNFR1	TNFR1	NNP
cord-016523-pznw2ciu	28	2	,	,	,
cord-016523-pznw2ciu	29	1	Fas	Fas	NNP
cord-016523-pznw2ciu	29	2	,	,	,
cord-016523-pznw2ciu	29	3	DR3	DR3	NNP
cord-016523-pznw2ciu	29	4	,	,	,
cord-016523-pznw2ciu	29	5	DR4	DR4	NNP
cord-016523-pznw2ciu	29	6	,	,	,
cord-016523-pznw2ciu	29	7	DR5	DR5	NNP
cord-016523-pznw2ciu	29	8	,	,	,
cord-016523-pznw2ciu	29	9	and	and	CC
cord-016523-pznw2ciu	29	10	DR6	dr6	NN
cord-016523-pznw2ciu	29	11	belong	belong	VBP
cord-016523-pznw2ciu	29	12	to	to	IN
cord-016523-pznw2ciu	29	13	the	the	DT
cord-016523-pznw2ciu	29	14	tumor	tumor	NN
cord-016523-pznw2ciu	29	15	necrosis	necrosis	NN
cord-016523-pznw2ciu	29	16	factor	factor	NN
cord-016523-pznw2ciu	29	17	receptor	receptor	NN
cord-016523-pznw2ciu	29	18	(	(	-LRB-
cord-016523-pznw2ciu	29	19	TNF	TNF	NNP
cord-016523-pznw2ciu	29	20	-	-	HYPH
cord-016523-pznw2ciu	29	21	R	R	NNP
cord-016523-pznw2ciu	29	22	)	)	-RRB-
cord-016523-pznw2ciu	29	23	superfamily	superfamily	NN
cord-016523-pznw2ciu	29	24	.	.	.
cord-016523-pznw2ciu	30	1	These	these	DT
cord-016523-pznw2ciu	30	2	type	type	NN
cord-016523-pznw2ciu	30	3	I	-PRON-	PRP
cord-016523-pznw2ciu	30	4	transmembrane	transmembrane	NN
cord-016523-pznw2ciu	30	5	proteins	protein	NNS
cord-016523-pznw2ciu	30	6	share	share	VBP
cord-016523-pznw2ciu	30	7	common	common	JJ
cord-016523-pznw2ciu	30	8	features	feature	NNS
cord-016523-pznw2ciu	30	9	,	,	,
cord-016523-pznw2ciu	30	10	such	such	JJ
cord-016523-pznw2ciu	30	11	as	as	IN
cord-016523-pznw2ciu	30	12	extracellular	extracellular	JJ
cord-016523-pznw2ciu	30	13	amino	amino	NN
cord-016523-pznw2ciu	30	14	-	-	HYPH
cord-016523-pznw2ciu	30	15	terminal	terminal	NN
cord-016523-pznw2ciu	30	16	cysteine	cysteine	NN
cord-016523-pznw2ciu	30	17	-	-	HYPH
cord-016523-pznw2ciu	30	18	rich	rich	JJ
cord-016523-pznw2ciu	30	19	domains	domain	NNS
cord-016523-pznw2ciu	30	20	(	(	-LRB-
cord-016523-pznw2ciu	30	21	CRDs	CRDs	NNP
cord-016523-pznw2ciu	30	22	)	)	-RRB-
cord-016523-pznw2ciu	30	23	[	[	-LRB-
cord-016523-pznw2ciu	30	24	19	19	CD
cord-016523-pznw2ciu	30	25	,	,	,
cord-016523-pznw2ciu	30	26	20	20	CD
cord-016523-pznw2ciu	30	27	]	]	-RRB-
cord-016523-pznw2ciu	30	28	,	,	,
cord-016523-pznw2ciu	30	29	which	which	WDT
cord-016523-pznw2ciu	30	30	contribute	contribute	VBP
cord-016523-pznw2ciu	30	31	to	to	IN
cord-016523-pznw2ciu	30	32	ligand	ligand	NN
cord-016523-pznw2ciu	30	33	specifi	specifi	NNP
cord-016523-pznw2ciu	30	34	city	city	NN
cord-016523-pznw2ciu	30	35	[	[	-LRB-
cord-016523-pznw2ciu	30	36	21	21	CD
cord-016523-pznw2ciu	30	37	]	]	-RRB-
cord-016523-pznw2ciu	30	38	,	,	,
cord-016523-pznw2ciu	30	39	and	and	CC
cord-016523-pznw2ciu	30	40	preassociation	preassociation	NN
cord-016523-pznw2ciu	30	41	of	of	IN
cord-016523-pznw2ciu	30	42	the	the	DT
cord-016523-pznw2ciu	30	43	receptor	receptor	NN
cord-016523-pznw2ciu	30	44	at	at	IN
cord-016523-pznw2ciu	30	45	the	the	DT
cord-016523-pznw2ciu	30	46	plasma	plasma	NN
cord-016523-pznw2ciu	30	47	membrane	membrane	NN
cord-016523-pznw2ciu	30	48	[	[	-LRB-
cord-016523-pznw2ciu	30	49	22	22	CD
cord-016523-pznw2ciu	30	50	-24	-24	,
cord-016523-pznw2ciu	30	51	]	]	-RRB-
cord-016523-pznw2ciu	30	52	and	and	CC
cord-016523-pznw2ciu	30	53	a	a	DT
cord-016523-pznw2ciu	30	54	conserved	conserve	VBN
cord-016523-pznw2ciu	30	55	80	80	CD
cord-016523-pznw2ciu	30	56	amino	amino	NN
cord-016523-pznw2ciu	30	57	acid	acid	NN
cord-016523-pznw2ciu	30	58	sequence	sequence	NN
cord-016523-pznw2ciu	30	59	located	locate	VBN
cord-016523-pznw2ciu	30	60	in	in	IN
cord-016523-pznw2ciu	30	61	their	-PRON-	PRP$
cord-016523-pznw2ciu	30	62	cytoplasmic	cytoplasmic	JJ
cord-016523-pznw2ciu	30	63	tail	tail	NN
cord-016523-pznw2ciu	30	64	called	call	VBN
cord-016523-pznw2ciu	30	65	death	death	NN
cord-016523-pznw2ciu	30	66	domain	domain	NN
cord-016523-pznw2ciu	30	67	(	(	-LRB-
cord-016523-pznw2ciu	30	68	DD	DD	NNP
cord-016523-pznw2ciu	30	69	)	)	-RRB-
cord-016523-pznw2ciu	30	70	,	,	,
cord-016523-pznw2ciu	30	71	which	which	WDT
cord-016523-pznw2ciu	30	72	is	be	VBZ
cord-016523-pznw2ciu	30	73	necessary	necessary	JJ
cord-016523-pznw2ciu	30	74	for	for	IN
cord-016523-pznw2ciu	30	75	DISC	disc	NN
cord-016523-pznw2ciu	30	76	formation	formation	NN
cord-016523-pznw2ciu	30	77	and	and	CC
cord-016523-pznw2ciu	30	78	initiation	initiation	NN
cord-016523-pznw2ciu	30	79	of	of	IN
cord-016523-pznw2ciu	30	80	the	the	DT
cord-016523-pznw2ciu	30	81	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	30	82	signal	signal	NN
cord-016523-pznw2ciu	30	83	[	[	-LRB-
cord-016523-pznw2ciu	30	84	25	25	CD
cord-016523-pznw2ciu	30	85	,	,	,
cord-016523-pznw2ciu	30	86	26	26	CD
cord-016523-pznw2ciu	30	87	]	]	-RRB-
cord-016523-pznw2ciu	30	88	.	.	.
cord-016523-pznw2ciu	31	1	TNF	TNF	NNP
cord-016523-pznw2ciu	31	2	-	-	HYPH
cord-016523-pznw2ciu	31	3	α	α	NNP
cord-016523-pznw2ciu	31	4	exerts	exert	VBZ
cord-016523-pznw2ciu	31	5	its	-PRON-	PRP$
cord-016523-pznw2ciu	31	6	effects	effect	NNS
cord-016523-pznw2ciu	31	7	by	by	IN
cord-016523-pznw2ciu	31	8	binding	bind	VBG
cord-016523-pznw2ciu	31	9	to	to	IN
cord-016523-pznw2ciu	31	10	two	two	CD
cord-016523-pznw2ciu	31	11	receptors	receptor	NNS
cord-016523-pznw2ciu	31	12	,	,	,
cord-016523-pznw2ciu	32	1	TNFR1	TNFR1	NNP
cord-016523-pznw2ciu	32	2	and	and	CC
cord-016523-pznw2ciu	32	3	TNFR2	TNFR2	NNP
cord-016523-pznw2ciu	32	4	[	[	-LRB-
cord-016523-pznw2ciu	32	5	20	20	CD
cord-016523-pznw2ciu	32	6	]	]	-RRB-
cord-016523-pznw2ciu	32	7	.	.	.
cord-016523-pznw2ciu	33	1	Recently	recently	RB
cord-016523-pznw2ciu	33	2	,	,	,
cord-016523-pznw2ciu	33	3	progranulin	progranulin	NNP
cord-016523-pznw2ciu	33	4	was	be	VBD
cord-016523-pznw2ciu	33	5	identifi	identifi	NNP
cord-016523-pznw2ciu	33	6	ed	ed	NNP
cord-016523-pznw2ciu	33	7	as	as	IN
cord-016523-pznw2ciu	33	8	a	a	DT
cord-016523-pznw2ciu	33	9	ligand	ligand	NN
cord-016523-pznw2ciu	33	10	of	of	IN
cord-016523-pznw2ciu	33	11	TNFR	TNFR	NNP
cord-016523-pznw2ciu	33	12	with	with	IN
cord-016523-pznw2ciu	33	13	a	a	DT
cord-016523-pznw2ciu	33	14	higher	high	JJR
cord-016523-pznw2ciu	33	15	affi	affi	JJ
cord-016523-pznw2ciu	33	16	nity	nity	NN
cord-016523-pznw2ciu	33	17	than	than	IN
cord-016523-pznw2ciu	33	18	TNF	TNF	NNP
cord-016523-pznw2ciu	33	19	-	-	HYPH
cord-016523-pznw2ciu	33	20	α	α	NNP
cord-016523-pznw2ciu	33	21	.	.	.
cord-016523-pznw2ciu	34	1	Progranulin	Progranulin	NNP
cord-016523-pznw2ciu	34	2	antagonizes	antagonize	VBZ
cord-016523-pznw2ciu	34	3	TNF	TNF	NNP
cord-016523-pznw2ciu	34	4	-	-	HYPH
cord-016523-pznw2ciu	34	5	α	α	NNP
cord-016523-pznw2ciu	34	6	signaling	signaling	NN
cord-016523-pznw2ciu	34	7	and	and	CC
cord-016523-pznw2ciu	34	8	plays	play	VBZ
cord-016523-pznw2ciu	34	9	a	a	DT
cord-016523-pznw2ciu	34	10	critical	critical	JJ
cord-016523-pznw2ciu	34	11	role	role	NN
cord-016523-pznw2ciu	34	12	in	in	IN
cord-016523-pznw2ciu	34	13	the	the	DT
cord-016523-pznw2ciu	34	14	pathogenesis	pathogenesis	NN
cord-016523-pznw2ciu	34	15	of	of	IN
cord-016523-pznw2ciu	34	16	infl	infl	NNP
cord-016523-pznw2ciu	34	17	ammatory	ammatory	NNP
cord-016523-pznw2ciu	34	18	arthritis	arthritis	NN
cord-016523-pznw2ciu	34	19	in	in	IN
cord-016523-pznw2ciu	34	20	mice	mouse	NNS
cord-016523-pznw2ciu	34	21	[	[	-LRB-
cord-016523-pznw2ciu	34	22	27	27	CD
cord-016523-pznw2ciu	34	23	]	]	-RRB-
cord-016523-pznw2ciu	34	24	.	.	.
cord-016523-pznw2ciu	35	1	TNFR1	TNFR1	NNP
cord-016523-pznw2ciu	35	2	,	,	,
cord-016523-pznw2ciu	35	3	a	a	DT
cord-016523-pznw2ciu	35	4	55	55	CD
cord-016523-pznw2ciu	35	5	kDa	kDa	NNP
cord-016523-pznw2ciu	35	6	protein	protein	NN
cord-016523-pznw2ciu	35	7	expressed	express	VBD
cord-016523-pznw2ciu	35	8	in	in	IN
cord-016523-pznw2ciu	35	9	almost	almost	RB
cord-016523-pznw2ciu	35	10	all	all	DT
cord-016523-pznw2ciu	35	11	cell	cell	NN
cord-016523-pznw2ciu	35	12	types	type	NNS
cord-016523-pznw2ciu	35	13	,	,	,
cord-016523-pznw2ciu	35	14	presents	present	VBZ
cord-016523-pznw2ciu	35	15	a	a	DT
cord-016523-pznw2ciu	35	16	DD	dd	NN
cord-016523-pznw2ciu	35	17	in	in	IN
cord-016523-pznw2ciu	35	18	its	-PRON-	PRP$
cord-016523-pznw2ciu	35	19	intracellular	intracellular	JJ
cord-016523-pznw2ciu	35	20	region	region	NN
cord-016523-pznw2ciu	35	21	;	;	,
cord-016523-pznw2ciu	35	22	whereas	whereas	IN
cord-016523-pznw2ciu	35	23	TNFR2	TNFR2	NNP
cord-016523-pznw2ciu	35	24	,	,	,
cord-016523-pznw2ciu	35	25	a	a	DT
cord-016523-pznw2ciu	35	26	75	75	CD
cord-016523-pznw2ciu	35	27	kDa	kDa	NNP
cord-016523-pznw2ciu	35	28	protein	protein	NN
cord-016523-pznw2ciu	35	29	,	,	,
cord-016523-pznw2ciu	35	30	is	be	VBZ
cord-016523-pznw2ciu	35	31	mainly	mainly	RB
cord-016523-pznw2ciu	35	32	detected	detect	VBN
cord-016523-pznw2ciu	35	33	in	in	IN
cord-016523-pznw2ciu	35	34	oligodendrocytes	oligodendrocyte	NNS
cord-016523-pznw2ciu	35	35	,	,	,
cord-016523-pznw2ciu	35	36	astrocytes	astrocyte	NNS
cord-016523-pznw2ciu	35	37	,	,	,
cord-016523-pznw2ciu	35	38	T	t	NN
cord-016523-pznw2ciu	35	39	cells	cell	NNS
cord-016523-pznw2ciu	35	40	,	,	,
cord-016523-pznw2ciu	35	41	myocytes	myocyte	NNS
cord-016523-pznw2ciu	35	42	,	,	,
cord-016523-pznw2ciu	35	43	thymocytes	thymocyte	NNS
cord-016523-pznw2ciu	35	44	,	,	,
cord-016523-pznw2ciu	35	45	endothelial	endothelial	JJ
cord-016523-pznw2ciu	35	46	cells	cell	NNS
cord-016523-pznw2ciu	35	47	,	,	,
cord-016523-pznw2ciu	35	48	and	and	CC
cord-016523-pznw2ciu	35	49	human	human	JJ
cord-016523-pznw2ciu	35	50	mesenchymal	mesenchymal	JJ
cord-016523-pznw2ciu	35	51	stem	stem	NN
cord-016523-pznw2ciu	35	52	cells	cell	NNS
cord-016523-pznw2ciu	35	53	[	[	-LRB-
cord-016523-pznw2ciu	35	54	28	28	CD
cord-016523-pznw2ciu	35	55	]	]	-RRB-
cord-016523-pznw2ciu	35	56	.	.	.
cord-016523-pznw2ciu	36	1	Uncertainty	uncertainty	NN
cord-016523-pznw2ciu	36	2	remains	remain	VBZ
cord-016523-pznw2ciu	36	3	on	on	IN
cord-016523-pznw2ciu	36	4	the	the	DT
cord-016523-pznw2ciu	36	5	TNFR2	tnfr2	NN
cord-016523-pznw2ciu	36	6	signaling	signal	VBG
cord-016523-pznw2ciu	36	7	pathway	pathway	NN
cord-016523-pznw2ciu	36	8	,	,	,
cord-016523-pznw2ciu	36	9	which	which	WDT
cord-016523-pznw2ciu	36	10	has	have	VBZ
cord-016523-pznw2ciu	36	11	been	be	VBN
cord-016523-pznw2ciu	36	12	previously	previously	RB
cord-016523-pznw2ciu	36	13	reviewed	review	VBN
cord-016523-pznw2ciu	36	14	[	[	-LRB-
cord-016523-pznw2ciu	36	15	28	28	CD
cord-016523-pznw2ciu	36	16	]	]	-RRB-
cord-016523-pznw2ciu	36	17	.	.	.
cord-016523-pznw2ciu	37	1	The	the	DT
cord-016523-pznw2ciu	37	2	CRD1	CRD1	NNP
cord-016523-pznw2ciu	37	3	of	of	IN
cord-016523-pznw2ciu	37	4	CD95	CD95	NNP
cord-016523-pznw2ciu	37	5	,	,	,
cord-016523-pznw2ciu	37	6	TNFR1	TNFR1	NNP
cord-016523-pznw2ciu	37	7	,	,	,
cord-016523-pznw2ciu	37	8	and	and	CC
cord-016523-pznw2ciu	37	9	TNFR2	tnfr2	NN
cord-016523-pznw2ciu	37	10	is	be	VBZ
cord-016523-pznw2ciu	37	11	involved	involve	VBN
cord-016523-pznw2ciu	37	12	in	in	IN
cord-016523-pznw2ciu	37	13	homotypic	homotypic	JJ
cord-016523-pznw2ciu	37	14	interactions	interaction	NNS
cord-016523-pznw2ciu	37	15	,	,	,
cord-016523-pznw2ciu	37	16	leading	lead	VBG
cord-016523-pznw2ciu	37	17	to	to	IN
cord-016523-pznw2ciu	37	18	pre	pre	VB
cord-016523-pznw2ciu	37	19	-	-	JJ
cord-016523-pznw2ciu	37	20	association	association	NN
cord-016523-pznw2ciu	37	21	of	of	IN
cord-016523-pznw2ciu	37	22	the	the	DT
cord-016523-pznw2ciu	37	23	receptor	receptor	NN
cord-016523-pznw2ciu	37	24	as	as	IN
cord-016523-pznw2ciu	37	25	a	a	DT
cord-016523-pznw2ciu	37	26	homotrimer	homotrimer	NN
cord-016523-pznw2ciu	37	27	in	in	IN
cord-016523-pznw2ciu	37	28	the	the	DT
cord-016523-pznw2ciu	37	29	absence	absence	NN
cord-016523-pznw2ciu	37	30	of	of	IN
cord-016523-pznw2ciu	37	31	ligand	ligand	NN
cord-016523-pznw2ciu	37	32	[	[	-LRB-
cord-016523-pznw2ciu	37	33	23	23	CD
cord-016523-pznw2ciu	37	34	,	,	,
cord-016523-pznw2ciu	37	35	24	24	CD
cord-016523-pznw2ciu	37	36	,	,	,
cord-016523-pznw2ciu	37	37	29	29	CD
cord-016523-pznw2ciu	37	38	]	]	-RRB-
cord-016523-pznw2ciu	37	39	.	.	.
cord-016523-pznw2ciu	38	1	This	this	DT
cord-016523-pznw2ciu	38	2	domain	domain	NN
cord-016523-pznw2ciu	38	3	has	have	VBZ
cord-016523-pznw2ciu	38	4	been	be	VBN
cord-016523-pznw2ciu	38	5	designated	designate	VBN
cord-016523-pznw2ciu	38	6	as	as	IN
cord-016523-pznw2ciu	38	7	the	the	DT
cord-016523-pznw2ciu	38	8	pre	pre	JJ
cord-016523-pznw2ciu	38	9	-	-	JJ
cord-016523-pznw2ciu	38	10	ligand	ligand	JJ
cord-016523-pznw2ciu	38	11	binding	binding	NN
cord-016523-pznw2ciu	38	12	assembly	assembly	NN
cord-016523-pznw2ciu	38	13	domain	domain	NN
cord-016523-pznw2ciu	38	14	(	(	-LRB-
cord-016523-pznw2ciu	38	15	PLAD	PLAD	NNP
cord-016523-pznw2ciu	38	16	)	)	-RRB-
cord-016523-pznw2ciu	38	17	[	[	-LRB-
cord-016523-pznw2ciu	38	18	29	29	CD
cord-016523-pznw2ciu	38	19	]	]	-RRB-
cord-016523-pznw2ciu	38	20	.	.	.
cord-016523-pznw2ciu	39	1	Receptors	receptor	NNS
cord-016523-pznw2ciu	39	2	of	of	IN
cord-016523-pznw2ciu	39	3	the	the	DT
cord-016523-pznw2ciu	39	4	TNFR	TNFR	NNP
cord-016523-pznw2ciu	39	5	superfamily	superfamily	NN
cord-016523-pznw2ciu	39	6	do	do	VBP
cord-016523-pznw2ciu	39	7	not	not	RB
cord-016523-pznw2ciu	39	8	possess	possess	VB
cord-016523-pznw2ciu	39	9	any	any	DT
cord-016523-pznw2ciu	39	10	enzymatic	enzymatic	JJ
cord-016523-pznw2ciu	39	11	activity	activity	NN
cord-016523-pznw2ciu	39	12	on	on	IN
cord-016523-pznw2ciu	39	13	their	-PRON-	PRP$
cord-016523-pznw2ciu	39	14	own	own	JJ
cord-016523-pznw2ciu	39	15	and	and	CC
cord-016523-pznw2ciu	39	16	rely	rely	VBP
cord-016523-pznw2ciu	39	17	on	on	IN
cord-016523-pznw2ciu	39	18	the	the	DT
cord-016523-pznw2ciu	39	19	recruitment	recruitment	NN
cord-016523-pznw2ciu	39	20	of	of	IN
cord-016523-pznw2ciu	39	21	adaptor	adaptor	NN
cord-016523-pznw2ciu	39	22	proteins	protein	NNS
cord-016523-pznw2ciu	39	23	for	for	IN
cord-016523-pznw2ciu	39	24	signaling	signal	VBG
cord-016523-pznw2ciu	39	25	.	.	.
cord-016523-pznw2ciu	40	1	Among	among	IN
cord-016523-pznw2ciu	40	2	these	these	DT
cord-016523-pznw2ciu	40	3	adaptor	adaptor	NN
cord-016523-pznw2ciu	40	4	proteins	protein	NNS
cord-016523-pznw2ciu	40	5	,	,	,
cord-016523-pznw2ciu	40	6	TRADD	TRADD	NNP
cord-016523-pznw2ciu	40	7	or	or	CC
cord-016523-pznw2ciu	40	8	FADD	FADD	NNP
cord-016523-pznw2ciu	40	9	are	be	VBP
cord-016523-pznw2ciu	40	10	instrumental	instrumental	JJ
cord-016523-pznw2ciu	40	11	in	in	IN
cord-016523-pznw2ciu	40	12	the	the	DT
cord-016523-pznw2ciu	40	13	implementation	implementation	NN
cord-016523-pznw2ciu	40	14	of	of	IN
cord-016523-pznw2ciu	40	15	cell	cell	NN
cord-016523-pznw2ciu	40	16	death	death	NN
cord-016523-pznw2ciu	40	17	processes	process	NNS
cord-016523-pznw2ciu	40	18	[	[	-LRB-
cord-016523-pznw2ciu	40	19	7	7	CD
cord-016523-pznw2ciu	40	20	-10	-10	NN
cord-016523-pznw2ciu	40	21	]	]	-RRB-
cord-016523-pznw2ciu	40	22	.	.	.
cord-016523-pznw2ciu	41	1	TNF	TNF	NNP
cord-016523-pznw2ciu	41	2	is	be	VBZ
cord-016523-pznw2ciu	41	3	synthesized	synthesize	VBN
cord-016523-pznw2ciu	41	4	as	as	IN
cord-016523-pznw2ciu	41	5	a	a	DT
cord-016523-pznw2ciu	41	6	26	26	CD
cord-016523-pznw2ciu	41	7	kDa	kDa	NNP
cord-016523-pznw2ciu	41	8	transmembrane	transmembrane	NNP
cord-016523-pznw2ciu	41	9	type	type	NN
cord-016523-pznw2ciu	41	10	II	II	NNP
cord-016523-pznw2ciu	41	11	protein	protein	NN
cord-016523-pznw2ciu	41	12	(	(	-LRB-
cord-016523-pznw2ciu	41	13	m	m	NNP
cord-016523-pznw2ciu	41	14	-	-	HYPH
cord-016523-pznw2ciu	41	15	TNF	TNF	NNP
cord-016523-pznw2ciu	41	16	)	)	-RRB-
cord-016523-pznw2ciu	41	17	of	of	IN
cord-016523-pznw2ciu	41	18	233	233	CD
cord-016523-pznw2ciu	41	19	amino	amino	JJ
cord-016523-pznw2ciu	41	20	acids	acid	NNS
cord-016523-pznw2ciu	41	21	[	[	-LRB-
cord-016523-pznw2ciu	41	22	30	30	CD
cord-016523-pznw2ciu	41	23	]	]	-RRB-
cord-016523-pznw2ciu	41	24	which	which	WDT
cord-016523-pznw2ciu	41	25	can	can	MD
cord-016523-pznw2ciu	41	26	be	be	VB
cord-016523-pznw2ciu	41	27	cleaved	cleave	VBN
cord-016523-pznw2ciu	41	28	by	by	IN
cord-016523-pznw2ciu	41	29	the	the	DT
cord-016523-pznw2ciu	41	30	metalloprotease	metalloprotease	NNP
cord-016523-pznw2ciu	41	31	TACE	TACE	NNP
cord-016523-pznw2ciu	41	32	[	[	-LRB-
cord-016523-pznw2ciu	41	33	31	31	CD
cord-016523-pznw2ciu	41	34	,	,	,
cord-016523-pznw2ciu	41	35	32	32	CD
cord-016523-pznw2ciu	41	36	]	]	-RRB-
cord-016523-pznw2ciu	41	37	to	to	TO
cord-016523-pznw2ciu	41	38	release	release	VB
cord-016523-pznw2ciu	41	39	the	the	DT
cord-016523-pznw2ciu	41	40	17	17	CD
cord-016523-pznw2ciu	41	41	kDa	kDa	NNP
cord-016523-pznw2ciu	41	42	soluble	soluble	JJ
cord-016523-pznw2ciu	41	43	form	form	NN
cord-016523-pznw2ciu	41	44	of	of	IN
cord-016523-pznw2ciu	41	45	the	the	DT
cord-016523-pznw2ciu	41	46	cytokine	cytokine	NN
cord-016523-pznw2ciu	41	47	(	(	-LRB-
cord-016523-pznw2ciu	41	48	cl	cl	NNP
cord-016523-pznw2ciu	41	49	-	-	HYPH
cord-016523-pznw2ciu	41	50	TNF	TNF	NNP
cord-016523-pznw2ciu	41	51	)	)	-RRB-
cord-016523-pznw2ciu	41	52	.	.	.
cord-016523-pznw2ciu	42	1	In	in	IN
cord-016523-pznw2ciu	42	2	contrast	contrast	NN
cord-016523-pznw2ciu	42	3	to	to	IN
cord-016523-pznw2ciu	42	4	cl	cl	NNP
cord-016523-pznw2ciu	42	5	-	-	HYPH
cord-016523-pznw2ciu	42	6	TNF	TNF	NNP
cord-016523-pznw2ciu	42	7	,	,	,
cord-016523-pznw2ciu	42	8	which	which	WDT
cord-016523-pznw2ciu	42	9	only	only	RB
cord-016523-pznw2ciu	42	10	activates	activate	VBZ
cord-016523-pznw2ciu	42	11	TNFR1	tnfr1	XX
cord-016523-pznw2ciu	42	12	,	,	,
cord-016523-pznw2ciu	42	13	m	m	NNP
cord-016523-pznw2ciu	42	14	-	-	HYPH
cord-016523-pznw2ciu	42	15	TNF	TNF	NNP
cord-016523-pznw2ciu	42	16	can	can	MD
cord-016523-pznw2ciu	42	17	bind	bind	VB
cord-016523-pznw2ciu	42	18	and	and	CC
cord-016523-pznw2ciu	42	19	activate	activate	VB
cord-016523-pznw2ciu	42	20	both	both	DT
cord-016523-pznw2ciu	42	21	TNFR1	tnfr1	XX
cord-016523-pznw2ciu	43	1	and	and	CC
cord-016523-pznw2ciu	43	2	TNFR2	TNFR2	NNP
cord-016523-pznw2ciu	43	3	[	[	-LRB-
cord-016523-pznw2ciu	43	4	33	33	CD
cord-016523-pznw2ciu	43	5	]	]	-RRB-
cord-016523-pznw2ciu	43	6	.	.	.
cord-016523-pznw2ciu	44	1	Activation	activation	NN
cord-016523-pznw2ciu	44	2	of	of	IN
cord-016523-pznw2ciu	44	3	TNFR1	TNFR1	NNP
cord-016523-pznw2ciu	44	4	leads	lead	VBZ
cord-016523-pznw2ciu	44	5	to	to	IN
cord-016523-pznw2ciu	44	6	the	the	DT
cord-016523-pznw2ciu	44	7	induction	induction	NN
cord-016523-pznw2ciu	44	8	of	of	IN
cord-016523-pznw2ciu	44	9	cellular	cellular	JJ
cord-016523-pznw2ciu	44	10	processes	process	NNS
cord-016523-pznw2ciu	44	11	ranging	range	VBG
cord-016523-pznw2ciu	44	12	from	from	IN
cord-016523-pznw2ciu	44	13	cell	cell	NN
cord-016523-pznw2ciu	44	14	death	death	NN
cord-016523-pznw2ciu	44	15	(	(	-LRB-
cord-016523-pznw2ciu	44	16	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	44	17	or	or	CC
cord-016523-pznw2ciu	44	18	necroptosis	necroptosis	NN
cord-016523-pznw2ciu	44	19	)	)	-RRB-
cord-016523-pznw2ciu	44	20	to	to	IN
cord-016523-pznw2ciu	44	21	cell	cell	NN
cord-016523-pznw2ciu	44	22	proliferation	proliferation	NN
cord-016523-pznw2ciu	44	23	,	,	,
cord-016523-pznw2ciu	44	24	migration	migration	NN
cord-016523-pznw2ciu	44	25	,	,	,
cord-016523-pznw2ciu	44	26	and	and	CC
cord-016523-pznw2ciu	44	27	differentiation	differentiation	NN
cord-016523-pznw2ciu	44	28	;	;	:
cord-016523-pznw2ciu	44	29	the	the	DT
cord-016523-pznw2ciu	44	30	implementation	implementation	NN
cord-016523-pznw2ciu	44	31	of	of	IN
cord-016523-pznw2ciu	44	32	such	such	JJ
cord-016523-pznw2ciu	44	33	different	different	JJ
cord-016523-pznw2ciu	44	34	cellular	cellular	JJ
cord-016523-pznw2ciu	44	35	responses	response	NNS
cord-016523-pznw2ciu	44	36	refl	refl	NNP
cord-016523-pznw2ciu	44	37	ects	ects	NNP
cord-016523-pznw2ciu	44	38	the	the	DT
cord-016523-pznw2ciu	44	39	formation	formation	NN
cord-016523-pznw2ciu	44	40	of	of	IN
cord-016523-pznw2ciu	44	41	different	different	JJ
cord-016523-pznw2ciu	44	42	molecular	molecular	JJ
cord-016523-pznw2ciu	44	43	complexes	complex	NNS
cord-016523-pznw2ciu	44	44	after	after	IN
cord-016523-pznw2ciu	44	45	receptor	receptor	NN
cord-016523-pznw2ciu	44	46	activation	activation	NN
cord-016523-pznw2ciu	44	47	[	[	-LRB-
cord-016523-pznw2ciu	44	48	28	28	CD
cord-016523-pznw2ciu	44	49	]	]	-RRB-
cord-016523-pznw2ciu	44	50	.	.	.
cord-016523-pznw2ciu	45	1	Binding	Binding	NNP
cord-016523-pznw2ciu	45	2	of	of	IN
cord-016523-pznw2ciu	45	3	TNF	TNF	NNP
cord-016523-pznw2ciu	45	4	to	to	IN
cord-016523-pznw2ciu	45	5	TNFR1	TNFR1	NNP
cord-016523-pznw2ciu	45	6	causes	cause	VBZ
cord-016523-pznw2ciu	45	7	the	the	DT
cord-016523-pznw2ciu	45	8	formation	formation	NN
cord-016523-pznw2ciu	45	9	of	of	IN
cord-016523-pznw2ciu	45	10	two	two	CD
cord-016523-pznw2ciu	45	11	consecutive	consecutive	JJ
cord-016523-pznw2ciu	45	12	complexes	complex	NNS
cord-016523-pznw2ciu	45	13	.	.	.
cord-016523-pznw2ciu	46	1	While	while	IN
cord-016523-pznw2ciu	46	2	the	the	DT
cord-016523-pznw2ciu	46	3	plasma	plasma	NN
cord-016523-pznw2ciu	46	4	membrane	membrane	NN
cord-016523-pznw2ciu	46	5	complex	complex	NN
cord-016523-pznw2ciu	46	6	(	(	-LRB-
cord-016523-pznw2ciu	46	7	complex	complex	JJ
cord-016523-pznw2ciu	46	8	I	i	NN
cord-016523-pznw2ciu	46	9	)	)	-RRB-
cord-016523-pznw2ciu	46	10	elicits	elicit	VBZ
cord-016523-pznw2ciu	46	11	a	a	DT
cord-016523-pznw2ciu	46	12	non	non	JJ
cord-016523-pznw2ciu	46	13	-	-	JJ
cord-016523-pznw2ciu	46	14	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	46	15	signaling	signal	VBG
cord-016523-pznw2ciu	46	16	pathway	pathway	NN
cord-016523-pznw2ciu	46	17	,	,	,
cord-016523-pznw2ciu	46	18	a	a	DT
cord-016523-pznw2ciu	46	19	second	second	NN
cord-016523-pznw2ciu	46	20	,	,	,
cord-016523-pznw2ciu	46	21	internalized	internalize	VBN
cord-016523-pznw2ciu	46	22	,	,	,
cord-016523-pznw2ciu	46	23	complex	complex	JJ
cord-016523-pznw2ciu	46	24	(	(	-LRB-
cord-016523-pznw2ciu	46	25	complex	complex	JJ
cord-016523-pznw2ciu	46	26	II	ii	CD
cord-016523-pznw2ciu	46	27	or	or	CC
cord-016523-pznw2ciu	46	28	DISC	DISC	NNP
cord-016523-pznw2ciu	46	29	)	)	-RRB-
cord-016523-pznw2ciu	46	30	triggers	trigger	VBZ
cord-016523-pznw2ciu	46	31	cell	cell	NN
cord-016523-pznw2ciu	46	32	death	death	NN
cord-016523-pznw2ciu	46	33	[	[	-LRB-
cord-016523-pznw2ciu	46	34	2	2	CD
cord-016523-pznw2ciu	46	35	]	]	-RRB-
cord-016523-pznw2ciu	46	36	.	.	.
cord-016523-pznw2ciu	47	1	In	in	IN
cord-016523-pznw2ciu	47	2	the	the	DT
cord-016523-pznw2ciu	47	3	presence	presence	NN
cord-016523-pznw2ciu	47	4	of	of	IN
cord-016523-pznw2ciu	47	5	TNF	TNF	NNP
cord-016523-pznw2ciu	47	6	,	,	,
cord-016523-pznw2ciu	47	7	the	the	DT
cord-016523-pznw2ciu	47	8	adaptor	adaptor	NN
cord-016523-pznw2ciu	47	9	protein	protein	NN
cord-016523-pznw2ciu	47	10	TRADD	TRADD	NNP
cord-016523-pznw2ciu	47	11	interacts	interact	VBZ
cord-016523-pznw2ciu	47	12	with	with	IN
cord-016523-pznw2ciu	47	13	TNFR1	TNFR1	NNP
cord-016523-pznw2ciu	47	14	and	and	CC
cord-016523-pznw2ciu	47	15	recruits	recruit	VBZ
cord-016523-pznw2ciu	47	16	other	other	JJ
cord-016523-pznw2ciu	47	17	proteins	protein	NNS
cord-016523-pznw2ciu	47	18	involved	involve	VBN
cord-016523-pznw2ciu	47	19	in	in	IN
cord-016523-pznw2ciu	47	20	the	the	DT
cord-016523-pznw2ciu	47	21	signaling	signaling	NN
cord-016523-pznw2ciu	47	22	of	of	IN
cord-016523-pznw2ciu	47	23	the	the	DT
cord-016523-pznw2ciu	47	24	receptor	receptor	NN
cord-016523-pznw2ciu	47	25	,	,	,
cord-016523-pznw2ciu	47	26	such	such	JJ
cord-016523-pznw2ciu	47	27	as	as	IN
cord-016523-pznw2ciu	47	28	TRAF2	TRAF2	NNP
cord-016523-pznw2ciu	47	29	,	,	,
cord-016523-pznw2ciu	47	30	cIAP1	ciap1	NN
cord-016523-pznw2ciu	47	31	,	,	,
cord-016523-pznw2ciu	47	32	cIAP2	ciap2	UH
cord-016523-pznw2ciu	47	33	,	,	,
cord-016523-pznw2ciu	47	34	and	and	CC
cord-016523-pznw2ciu	47	35	RIP1	RIP1	NNP
cord-016523-pznw2ciu	47	36	,	,	,
cord-016523-pznw2ciu	47	37	to	to	TO
cord-016523-pznw2ciu	47	38	form	form	VB
cord-016523-pznw2ciu	47	39	complex	complex	JJ
cord-016523-pznw2ciu	47	40	I.	i.	NN
cord-016523-pznw2ciu	48	1	At	at	IN
cord-016523-pznw2ciu	48	2	the	the	DT
cord-016523-pznw2ciu	48	3	plasma	plasma	NN
cord-016523-pznw2ciu	48	4	membrane	membrane	NN
cord-016523-pznw2ciu	48	5	,	,	,
cord-016523-pznw2ciu	48	6	this	this	DT
cord-016523-pznw2ciu	48	7	complex	complex	NN
cord-016523-pznw2ciu	48	8	activates	activate	VBZ
cord-016523-pznw2ciu	48	9	the	the	DT
cord-016523-pznw2ciu	48	10	NF	nf	NN
cord-016523-pznw2ciu	48	11	-	-	HYPH
cord-016523-pznw2ciu	48	12	κB	κB	NNP
cord-016523-pznw2ciu	48	13	signaling	signal	VBG
cord-016523-pznw2ciu	48	14	pathway	pathway	NN
cord-016523-pznw2ciu	48	15	,	,	,
cord-016523-pznw2ciu	48	16	which	which	WDT
cord-016523-pznw2ciu	48	17	in	in	IN
cord-016523-pznw2ciu	48	18	turn	turn	NN
cord-016523-pznw2ciu	48	19	promotes	promote	VBZ
cord-016523-pznw2ciu	48	20	the	the	DT
cord-016523-pznw2ciu	48	21	transcription	transcription	NN
cord-016523-pznw2ciu	48	22	of	of	IN
cord-016523-pznw2ciu	48	23	antiapoptotic	antiapoptotic	JJ
cord-016523-pznw2ciu	48	24	genes	gene	NNS
cord-016523-pznw2ciu	48	25	such	such	JJ
cord-016523-pznw2ciu	48	26	as	as	IN
cord-016523-pznw2ciu	48	27	cIAP-1	ciap-1	CD
cord-016523-pznw2ciu	48	28	,	,	,
cord-016523-pznw2ciu	48	29	cIAP-2	ciap-2	CD
cord-016523-pznw2ciu	48	30	,	,	,
cord-016523-pznw2ciu	48	31	and	and	CC
cord-016523-pznw2ciu	48	32	c	c	LS
cord-016523-pznw2ciu	48	33	-	-	:
cord-016523-pznw2ciu	48	34	FLIP	FLIP	NNP
cord-016523-pznw2ciu	48	35	[	[	-LRB-
cord-016523-pznw2ciu	48	36	34	34	CD
cord-016523-pznw2ciu	48	37	]	]	-RRB-
cord-016523-pznw2ciu	48	38	.	.	.
cord-016523-pznw2ciu	49	1	The	the	DT
cord-016523-pznw2ciu	49	2	linear	linear	JJ
cord-016523-pznw2ciu	49	3	ubiquitin	ubiquitin	NN
cord-016523-pznw2ciu	49	4	chain	chain	NN
cord-016523-pznw2ciu	49	5	assembly	assembly	NN
cord-016523-pznw2ciu	49	6	complex	complex	NN
cord-016523-pznw2ciu	49	7	(	(	-LRB-
cord-016523-pznw2ciu	49	8	LUBAC	LUBAC	NNP
cord-016523-pznw2ciu	49	9	)	)	-RRB-
cord-016523-pznw2ciu	49	10	is	be	VBZ
cord-016523-pznw2ciu	49	11	also	also	RB
cord-016523-pznw2ciu	49	12	recruited	recruit	VBN
cord-016523-pznw2ciu	49	13	to	to	TO
cord-016523-pznw2ciu	49	14	complex	complex	VB
cord-016523-pznw2ciu	49	15	I	-PRON-	PRP
cord-016523-pznw2ciu	49	16	via	via	IN
cord-016523-pznw2ciu	49	17	cIAP	ciap	NN
cord-016523-pznw2ciu	49	18	-	-	HYPH
cord-016523-pznw2ciu	49	19	generated	generate	VBN
cord-016523-pznw2ciu	49	20	ubiquitin	ubiquitin	NN
cord-016523-pznw2ciu	49	21	chains	chain	NNS
cord-016523-pznw2ciu	49	22	[	[	-LRB-
cord-016523-pznw2ciu	49	23	35	35	CD
cord-016523-pznw2ciu	49	24	]	]	-RRB-
cord-016523-pznw2ciu	49	25	.	.	.
cord-016523-pznw2ciu	50	1	HOIL-1	HOIL-1	NNP
cord-016523-pznw2ciu	50	2	,	,	,
cord-016523-pznw2ciu	50	3	HOIP	HOIP	NNP
cord-016523-pznw2ciu	50	4	,	,	,
cord-016523-pznw2ciu	50	5	and	and	CC
cord-016523-pznw2ciu	50	6	sharpin	sharpin	NNP
cord-016523-pznw2ciu	50	7	constitute	constitute	VBP
cord-016523-pznw2ciu	50	8	the	the	DT
cord-016523-pznw2ciu	50	9	LUBAC	LUBAC	NNP
cord-016523-pznw2ciu	50	10	complex	complex	NN
cord-016523-pznw2ciu	50	11	.	.	.
cord-016523-pznw2ciu	51	1	HOIL-1	HOIL-1	NNP
cord-016523-pznw2ciu	51	2	and	and	CC
cord-016523-pznw2ciu	51	3	HOIP	HOIP	NNP
cord-016523-pznw2ciu	51	4	add	add	VBP
cord-016523-pznw2ciu	51	5	a	a	DT
cord-016523-pznw2ciu	51	6	linear	linear	JJ
cord-016523-pznw2ciu	51	7	ubiquitin	ubiquitin	NN
cord-016523-pznw2ciu	51	8	chain	chain	NN
cord-016523-pznw2ciu	51	9	by	by	IN
cord-016523-pznw2ciu	51	10	catalyzing	catalyze	VBG
cord-016523-pznw2ciu	51	11	the	the	DT
cord-016523-pznw2ciu	51	12	head	head	NN
cord-016523-pznw2ciu	51	13	-	-	HYPH
cord-016523-pznw2ciu	51	14	to	to	IN
cord-016523-pznw2ciu	51	15	-	-	HYPH
cord-016523-pznw2ciu	51	16	tail	tail	NN
cord-016523-pznw2ciu	51	17	ligation	ligation	NN
cord-016523-pznw2ciu	51	18	of	of	IN
cord-016523-pznw2ciu	51	19	ubiquitin	ubiquitin	NN
cord-016523-pznw2ciu	51	20	[	[	-LRB-
cord-016523-pznw2ciu	51	21	36	36	CD
cord-016523-pznw2ciu	51	22	]	]	-RRB-
cord-016523-pznw2ciu	51	23	to	to	IN
cord-016523-pznw2ciu	51	24	RIP1	RIP1	NNP
cord-016523-pznw2ciu	51	25	and	and	CC
cord-016523-pznw2ciu	51	26	NEMO	NEMO	NNP
cord-016523-pznw2ciu	51	27	(	(	-LRB-
cord-016523-pznw2ciu	51	28	IKKγ	IKKγ	NNPS
cord-016523-pznw2ciu	51	29	)	)	-RRB-
cord-016523-pznw2ciu	51	30	in	in	IN
cord-016523-pznw2ciu	51	31	complex	complex	NN
cord-016523-pznw2ciu	52	1	I	-PRON-	PRP
cord-016523-pznw2ciu	52	2	[	[	-LRB-
cord-016523-pznw2ciu	52	3	37	37	CD
cord-016523-pznw2ciu	52	4	]	]	-RRB-
cord-016523-pznw2ciu	52	5	,	,	,
cord-016523-pznw2ciu	52	6	thereby	thereby	RB
cord-016523-pznw2ciu	52	7	activating	activate	VBG
cord-016523-pznw2ciu	52	8	NF	nf	NN
cord-016523-pznw2ciu	52	9	-	-	HYPH
cord-016523-pznw2ciu	52	10	κB.	κb.	NN
cord-016523-pznw2ciu	52	11	TNF	TNF	NNP
cord-016523-pznw2ciu	52	12	-	-	HYPH
cord-016523-pznw2ciu	52	13	induced	induce	VBN
cord-016523-pznw2ciu	52	14	caspase	caspase	NN
cord-016523-pznw2ciu	52	15	activation	activation	NN
cord-016523-pznw2ciu	52	16	is	be	VBZ
cord-016523-pznw2ciu	52	17	mediated	mediate	VBN
cord-016523-pznw2ciu	52	18	by	by	IN
cord-016523-pznw2ciu	52	19	a	a	DT
cord-016523-pznw2ciu	52	20	second	second	JJ
cord-016523-pznw2ciu	52	21	,	,	,
cord-016523-pznw2ciu	52	22	intracellular	intracellular	JJ
cord-016523-pznw2ciu	52	23	complex	complex	JJ
cord-016523-pznw2ciu	52	24	II	II	NNP
cord-016523-pznw2ciu	52	25	,	,	,
cord-016523-pznw2ciu	52	26	which	which	WDT
cord-016523-pznw2ciu	52	27	is	be	VBZ
cord-016523-pznw2ciu	52	28	formed	form	VBN
cord-016523-pznw2ciu	52	29	when	when	WRB
cord-016523-pznw2ciu	52	30	complex	complex	JJ
cord-016523-pznw2ciu	52	31	I	-PRON-	PRP
cord-016523-pznw2ciu	52	32	dissociates	dissociate	VBZ
cord-016523-pznw2ciu	52	33	from	from	IN
cord-016523-pznw2ciu	52	34	the	the	DT
cord-016523-pznw2ciu	52	35	receptor	receptor	NN
cord-016523-pznw2ciu	52	36	,	,	,
cord-016523-pznw2ciu	52	37	along	along	IN
cord-016523-pznw2ciu	52	38	with	with	IN
cord-016523-pznw2ciu	52	39	FADD	FADD	NNP
cord-016523-pznw2ciu	52	40	and	and	CC
cord-016523-pznw2ciu	52	41	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	52	42	recruitment	recruitment	NN
cord-016523-pznw2ciu	52	43	[	[	-LRB-
cord-016523-pznw2ciu	52	44	2	2	CD
cord-016523-pznw2ciu	52	45	]	]	-RRB-
cord-016523-pznw2ciu	52	46	.	.	.
cord-016523-pznw2ciu	53	1	NF	NF	NNP
cord-016523-pznw2ciu	53	2	-	-	HYPH
cord-016523-pznw2ciu	53	3	κB	κb	CD
cord-016523-pznw2ciu	53	4	activation	activation	NN
cord-016523-pznw2ciu	53	5	leads	lead	VBZ
cord-016523-pznw2ciu	53	6	to	to	IN
cord-016523-pznw2ciu	53	7	c	c	NN
cord-016523-pznw2ciu	53	8	-	-	HYPH
cord-016523-pznw2ciu	53	9	FLIP	flip	NN
cord-016523-pznw2ciu	53	10	overexpression	overexpression	NN
cord-016523-pznw2ciu	53	11	,	,	,
cord-016523-pznw2ciu	53	12	preventing	prevent	VBG
cord-016523-pznw2ciu	53	13	formation	formation	NN
cord-016523-pznw2ciu	53	14	of	of	IN
cord-016523-pznw2ciu	53	15	complex	complex	JJ
cord-016523-pznw2ciu	53	16	II	ii	CD
cord-016523-pznw2ciu	53	17	.	.	.
cord-016523-pznw2ciu	54	1	Contrariwise	contrariwise	RB
cord-016523-pznw2ciu	54	2	,	,	,
cord-016523-pznw2ciu	54	3	when	when	WRB
cord-016523-pznw2ciu	54	4	NF	nf	NN
cord-016523-pznw2ciu	54	5	-	-	HYPH
cord-016523-pznw2ciu	54	6	κB	κb	CD
cord-016523-pznw2ciu	54	7	activation	activation	NN
cord-016523-pznw2ciu	54	8	is	be	VBZ
cord-016523-pznw2ciu	54	9	blocked	block	VBN
cord-016523-pznw2ciu	54	10	,	,	,
cord-016523-pznw2ciu	54	11	c	c	NN
cord-016523-pznw2ciu	54	12	-	-	:
cord-016523-pznw2ciu	54	13	FLIP	FLIP	NNP
cord-016523-pznw2ciu	54	14	,	,	,
cord-016523-pznw2ciu	54	15	whose	whose	WP$
cord-016523-pznw2ciu	54	16	protein	protein	NN
cord-016523-pznw2ciu	54	17	halflife	halflife	NN
cord-016523-pznw2ciu	54	18	is	be	VBZ
cord-016523-pznw2ciu	54	19	short	short	JJ
cord-016523-pznw2ciu	54	20	[	[	-LRB-
cord-016523-pznw2ciu	54	21	38	38	CD
cord-016523-pznw2ciu	54	22	]	]	-RRB-
cord-016523-pznw2ciu	54	23	,	,	,
cord-016523-pznw2ciu	54	24	is	be	VBZ
cord-016523-pznw2ciu	54	25	absent	absent	JJ
cord-016523-pznw2ciu	54	26	,	,	,
cord-016523-pznw2ciu	54	27	and	and	CC
cord-016523-pznw2ciu	54	28	cells	cell	NNS
cord-016523-pznw2ciu	54	29	experience	experience	VBP
cord-016523-pznw2ciu	54	30	death	death	NN
cord-016523-pznw2ciu	54	31	[	[	-LRB-
cord-016523-pznw2ciu	54	32	2	2	CD
cord-016523-pznw2ciu	54	33	]	]	-RRB-
cord-016523-pznw2ciu	54	34	.	.	.
cord-016523-pznw2ciu	55	1	RIP1	RIP1	NNP
cord-016523-pznw2ciu	55	2	is	be	VBZ
cord-016523-pznw2ciu	55	3	deubiquitinated	deubiquitinate	VBN
cord-016523-pznw2ciu	55	4	by	by	IN
cord-016523-pznw2ciu	55	5	enzymes	enzyme	NNS
cord-016523-pznw2ciu	55	6	such	such	JJ
cord-016523-pznw2ciu	55	7	as	as	IN
cord-016523-pznw2ciu	55	8	Cezanne	Cezanne	NNP
cord-016523-pznw2ciu	55	9	[	[	-LRB-
cord-016523-pznw2ciu	55	10	39	39	CD
cord-016523-pznw2ciu	55	11	]	]	-RRB-
cord-016523-pznw2ciu	55	12	and	and	CC
cord-016523-pznw2ciu	55	13	CYLD	CYLD	NNP
cord-016523-pznw2ciu	55	14	[	[	-LRB-
cord-016523-pznw2ciu	55	15	40	40	CD
cord-016523-pznw2ciu	55	16	]	]	-RRB-
cord-016523-pznw2ciu	55	17	and	and	CC
cord-016523-pznw2ciu	55	18	the	the	DT
cord-016523-pznw2ciu	55	19	complex	complex	NN
cord-016523-pznw2ciu	55	20	composed	compose	VBN
cord-016523-pznw2ciu	55	21	of	of	IN
cord-016523-pznw2ciu	55	22	TRADD	TRADD	NNP
cord-016523-pznw2ciu	55	23	and	and	CC
cord-016523-pznw2ciu	55	24	RIP1	RIP1	NNP
cord-016523-pznw2ciu	55	25	moves	move	NNS
cord-016523-pznw2ciu	55	26	to	to	IN
cord-016523-pznw2ciu	55	27	the	the	DT
cord-016523-pznw2ciu	55	28	cytosol	cytosol	NN
cord-016523-pznw2ciu	55	29	to	to	TO
cord-016523-pznw2ciu	55	30	form	form	VB
cord-016523-pznw2ciu	55	31	complex	complex	JJ
cord-016523-pznw2ciu	55	32	II	II	NNP
cord-016523-pznw2ciu	55	33	.	.	.
cord-016523-pznw2ciu	56	1	FADD	FADD	NNP
cord-016523-pznw2ciu	56	2	is	be	VBZ
cord-016523-pznw2ciu	56	3	recruited	recruit	VBN
cord-016523-pznw2ciu	56	4	to	to	IN
cord-016523-pznw2ciu	56	5	TRADD	TRADD	NNP
cord-016523-pznw2ciu	56	6	by	by	IN
cord-016523-pznw2ciu	56	7	DD	DD	NNP
cord-016523-pznw2ciu	56	8	-	-	HYPH
cord-016523-pznw2ciu	56	9	DD	DD	NNP
cord-016523-pznw2ciu	56	10	interaction	interaction	NN
cord-016523-pznw2ciu	56	11	and	and	CC
cord-016523-pznw2ciu	56	12	binds	bind	VBZ
cord-016523-pznw2ciu	56	13	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	56	14	[	[	-LRB-
cord-016523-pznw2ciu	56	15	2	2	CD
cord-016523-pznw2ciu	56	16	]	]	-RRB-
cord-016523-pznw2ciu	56	17	.	.	.
cord-016523-pznw2ciu	57	1	Noteworthy	noteworthy	JJ
cord-016523-pznw2ciu	57	2	,	,	,
cord-016523-pznw2ciu	57	3	when	when	WRB
cord-016523-pznw2ciu	57	4	caspase-8	caspase-8	JJ
cord-016523-pznw2ciu	57	5	activity	activity	NN
cord-016523-pznw2ciu	57	6	is	be	VBZ
cord-016523-pznw2ciu	57	7	inhibited	inhibit	VBN
cord-016523-pznw2ciu	57	8	or	or	CC
cord-016523-pznw2ciu	57	9	its	-PRON-	PRP$
cord-016523-pznw2ciu	57	10	expression	expression	NN
cord-016523-pznw2ciu	57	11	is	be	VBZ
cord-016523-pznw2ciu	57	12	extinguished	extinguish	VBN
cord-016523-pznw2ciu	57	13	,	,	,
cord-016523-pznw2ciu	57	14	DISC	DISC	NNP
cord-016523-pznw2ciu	57	15	is	be	VBZ
cord-016523-pznw2ciu	57	16	unable	unable	JJ
cord-016523-pznw2ciu	57	17	to	to	TO
cord-016523-pznw2ciu	57	18	trigger	trigger	VB
cord-016523-pznw2ciu	57	19	the	the	DT
cord-016523-pznw2ciu	57	20	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	57	21	signaling	signal	VBG
cord-016523-pznw2ciu	57	22	pathway	pathway	NN
cord-016523-pznw2ciu	57	23	,	,	,
cord-016523-pznw2ciu	57	24	but	but	CC
cord-016523-pznw2ciu	57	25	TNFR1	TNFR1	NNP
cord-016523-pznw2ciu	57	26	or	or	CC
cord-016523-pznw2ciu	57	27	CD95	CD95	NNP
cord-016523-pznw2ciu	57	28	stimulation	stimulation	NN
cord-016523-pznw2ciu	57	29	leads	lead	VBZ
cord-016523-pznw2ciu	57	30	to	to	IN
cord-016523-pznw2ciu	57	31	the	the	DT
cord-016523-pznw2ciu	57	32	activation	activation	NN
cord-016523-pznw2ciu	57	33	of	of	IN
cord-016523-pznw2ciu	57	34	another	another	DT
cord-016523-pznw2ciu	57	35	cell	cell	NN
cord-016523-pznw2ciu	57	36	death	death	NN
cord-016523-pznw2ciu	57	37	signal	signal	NN
cord-016523-pznw2ciu	57	38	,	,	,
cord-016523-pznw2ciu	57	39	namely	namely	RB
cord-016523-pznw2ciu	57	40	,	,	,
cord-016523-pznw2ciu	57	41	necroptosis	necroptosis	NNP
cord-016523-pznw2ciu	57	42	[	[	-LRB-
cord-016523-pznw2ciu	57	43	41	41	CD
cord-016523-pznw2ciu	57	44	,	,	,
cord-016523-pznw2ciu	57	45	42	42	CD
cord-016523-pznw2ciu	57	46	]	]	-RRB-
cord-016523-pznw2ciu	57	47	.	.	.
cord-016523-pznw2ciu	58	1	To	to	TO
cord-016523-pznw2ciu	58	2	prevent	prevent	VB
cord-016523-pznw2ciu	58	3	the	the	DT
cord-016523-pznw2ciu	58	4	induction	induction	NN
cord-016523-pznw2ciu	58	5	of	of	IN
cord-016523-pznw2ciu	58	6	the	the	DT
cord-016523-pznw2ciu	58	7	necroptotic	necroptotic	JJ
cord-016523-pznw2ciu	58	8	signal	signal	NN
cord-016523-pznw2ciu	58	9	,	,	,
cord-016523-pznw2ciu	58	10	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	58	11	cleaves	cleave	VBZ
cord-016523-pznw2ciu	58	12	and	and	CC
cord-016523-pznw2ciu	58	13	inactivates	inactivate	VBZ
cord-016523-pznw2ciu	58	14	RIP1	RIP1	NNP
cord-016523-pznw2ciu	58	15	and	and	CC
cord-016523-pznw2ciu	58	16	RIP3	RIP3	NNPS
cord-016523-pznw2ciu	58	17	[	[	-LRB-
cord-016523-pznw2ciu	58	18	43	43	CD
cord-016523-pznw2ciu	58	19	]	]	-RRB-
cord-016523-pznw2ciu	58	20	.	.	.
cord-016523-pznw2ciu	59	1	The	the	DT
cord-016523-pznw2ciu	59	2	fi	fi	NNP
cord-016523-pznw2ciu	59	3	ne	ne	NNP
cord-016523-pznw2ciu	59	4	-	-	HYPH
cord-016523-pznw2ciu	59	5	tuned	tune	VBN
cord-016523-pznw2ciu	59	6	control	control	NN
cord-016523-pznw2ciu	59	7	of	of	IN
cord-016523-pznw2ciu	59	8	necroptosis	necroptosis	NNP
cord-016523-pznw2ciu	59	9	by	by	IN
cord-016523-pznw2ciu	59	10	members	member	NNS
cord-016523-pznw2ciu	59	11	of	of	IN
cord-016523-pznw2ciu	59	12	the	the	DT
cord-016523-pznw2ciu	59	13	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	59	14	signaling	signal	VBG
cord-016523-pznw2ciu	59	15	pathway	pathway	NN
cord-016523-pznw2ciu	59	16	in	in	IN
cord-016523-pznw2ciu	59	17	the	the	DT
cord-016523-pznw2ciu	59	18	organism	organism	NN
cord-016523-pznw2ciu	59	19	has	have	VBZ
cord-016523-pznw2ciu	59	20	been	be	VBN
cord-016523-pznw2ciu	59	21	elegantly	elegantly	RB
cord-016523-pznw2ciu	59	22	confi	confi	VBN
cord-016523-pznw2ciu	59	23	rmed	rme	VBN
cord-016523-pznw2ciu	59	24	by	by	IN
cord-016523-pznw2ciu	59	25	experiments	experiment	NNS
cord-016523-pznw2ciu	59	26	showing	show	VBG
cord-016523-pznw2ciu	59	27	that	that	IN
cord-016523-pznw2ciu	59	28	the	the	DT
cord-016523-pznw2ciu	59	29	embryonic	embryonic	JJ
cord-016523-pznw2ciu	59	30	lethality	lethality	NN
cord-016523-pznw2ciu	59	31	of	of	IN
cord-016523-pznw2ciu	59	32	mice	mouse	NNS
cord-016523-pznw2ciu	59	33	harboring	harbor	VBG
cord-016523-pznw2ciu	59	34	the	the	DT
cord-016523-pznw2ciu	59	35	single	single	JJ
cord-016523-pznw2ciu	59	36	KO	KO	NNP
cord-016523-pznw2ciu	59	37	of	of	IN
cord-016523-pznw2ciu	59	38	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	59	39	or	or	CC
cord-016523-pznw2ciu	59	40	FADD	FADD	NNP
cord-016523-pznw2ciu	59	41	is	be	VBZ
cord-016523-pznw2ciu	59	42	rescued	rescue	VBN
cord-016523-pznw2ciu	59	43	by	by	IN
cord-016523-pznw2ciu	59	44	an	an	DT
cord-016523-pznw2ciu	59	45	additional	additional	JJ
cord-016523-pznw2ciu	59	46	KO	ko	NN
cord-016523-pznw2ciu	59	47	of	of	IN
cord-016523-pznw2ciu	59	48	the	the	DT
cord-016523-pznw2ciu	59	49	RIP3	RIP3	NNP
cord-016523-pznw2ciu	59	50	gene	gene	NN
cord-016523-pznw2ciu	59	51	[	[	-LRB-
cord-016523-pznw2ciu	59	52	44	44	CD
cord-016523-pznw2ciu	59	53	-46	-46	NN
cord-016523-pznw2ciu	59	54	]	]	-RRB-
cord-016523-pznw2ciu	59	55	.	.	.
cord-016523-pznw2ciu	60	1	Many	many	JJ
cord-016523-pznw2ciu	60	2	studies	study	NNS
cord-016523-pznw2ciu	60	3	on	on	IN
cord-016523-pznw2ciu	60	4	TNF	TNF	NNP
cord-016523-pznw2ciu	60	5	demonstrated	demonstrate	VBD
cord-016523-pznw2ciu	60	6	its	-PRON-	PRP$
cord-016523-pznw2ciu	60	7	pivotal	pivotal	JJ
cord-016523-pznw2ciu	60	8	role	role	NN
cord-016523-pznw2ciu	60	9	in	in	IN
cord-016523-pznw2ciu	60	10	fueling	fuel	VBG
cord-016523-pznw2ciu	60	11	infl	infl	NN
cord-016523-pznw2ciu	60	12	ammation	ammation	NN
cord-016523-pznw2ciu	60	13	,	,	,
cord-016523-pznw2ciu	60	14	a	a	DT
cord-016523-pznw2ciu	60	15	multistep	multistep	JJ
cord-016523-pznw2ciu	60	16	process	process	NN
cord-016523-pznw2ciu	60	17	that	that	WDT
cord-016523-pznw2ciu	60	18	promotes	promote	VBZ
cord-016523-pznw2ciu	60	19	autoimmunity	autoimmunity	NN
cord-016523-pznw2ciu	60	20	(	(	-LRB-
cord-016523-pznw2ciu	60	21	e.g.	e.g.	RB
cord-016523-pznw2ciu	60	22	,	,	,
cord-016523-pznw2ciu	60	23	rheumatoid	rheumatoid	NN
cord-016523-pznw2ciu	60	24	arthritis	arthritis	NN
cord-016523-pznw2ciu	60	25	,	,	,
cord-016523-pznw2ciu	60	26	ankylosing	ankylosing	NN
cord-016523-pznw2ciu	60	27	spondylitis	spondylitis	NN
cord-016523-pznw2ciu	60	28	,	,	,
cord-016523-pznw2ciu	60	29	Crohn	Crohn	NNP
cord-016523-pznw2ciu	60	30	's	's	POS
cord-016523-pznw2ciu	60	31	disease	disease	NN
cord-016523-pznw2ciu	60	32	,	,	,
cord-016523-pznw2ciu	60	33	psoriasis	psoriasis	NN
cord-016523-pznw2ciu	60	34	,	,	,
cord-016523-pznw2ciu	60	35	and	and	CC
cord-016523-pznw2ciu	60	36	refractory	refractory	JJ
cord-016523-pznw2ciu	60	37	asthma	asthma	NN
cord-016523-pznw2ciu	60	38	)	)	-RRB-
cord-016523-pznw2ciu	60	39	and	and	CC
cord-016523-pznw2ciu	60	40	cancer	cancer	NN
cord-016523-pznw2ciu	60	41	.	.	.
cord-016523-pznw2ciu	61	1	Many	many	JJ
cord-016523-pznw2ciu	61	2	TNF	TNF	NNP
cord-016523-pznw2ciu	61	3	inhibitors	inhibitor	NNS
cord-016523-pznw2ciu	61	4	,	,	,
cord-016523-pznw2ciu	61	5	such	such	JJ
cord-016523-pznw2ciu	61	6	as	as	IN
cord-016523-pznw2ciu	61	7	neutralizing	neutralize	VBG
cord-016523-pznw2ciu	61	8	monoclonal	monoclonal	JJ
cord-016523-pznw2ciu	61	9	antibodies	antibody	NNS
cord-016523-pznw2ciu	61	10	(	(	-LRB-
cord-016523-pznw2ciu	61	11	mAbs	mabs	NN
cord-016523-pznw2ciu	61	12	)	)	-RRB-
cord-016523-pznw2ciu	61	13	(	(	-LRB-
cord-016523-pznw2ciu	61	14	e.g.	e.g.	RB
cord-016523-pznw2ciu	61	15	,	,	,
cord-016523-pznw2ciu	61	16	infl	infl	NNP
cord-016523-pznw2ciu	61	17	iximab	iximab	NNP
cord-016523-pznw2ciu	61	18	,	,	,
cord-016523-pznw2ciu	61	19	adalimumab	adalimumab	NNS
cord-016523-pznw2ciu	61	20	,	,	,
cord-016523-pznw2ciu	61	21	and	and	CC
cord-016523-pznw2ciu	61	22	golimumab	golimumab	NNP
cord-016523-pznw2ciu	61	23	)	)	-RRB-
cord-016523-pznw2ciu	61	24	,	,	,
cord-016523-pznw2ciu	61	25	have	have	VBP
cord-016523-pznw2ciu	61	26	been	be	VBN
cord-016523-pznw2ciu	61	27	developed	develop	VBN
cord-016523-pznw2ciu	61	28	to	to	TO
cord-016523-pznw2ciu	61	29	treat	treat	VB
cord-016523-pznw2ciu	61	30	these	these	DT
cord-016523-pznw2ciu	61	31	chronic	chronic	JJ
cord-016523-pznw2ciu	61	32	infl	infl	NN
cord-016523-pznw2ciu	61	33	ammatory	ammatory	NN
cord-016523-pznw2ciu	61	34	disorders	disorder	NNS
cord-016523-pznw2ciu	61	35	,	,	,
cord-016523-pznw2ciu	61	36	demonstrating	demonstrate	VBG
cord-016523-pznw2ciu	61	37	that	that	IN
cord-016523-pznw2ciu	61	38	altering	alter	VBG
cord-016523-pznw2ciu	61	39	ligand	ligand	NN
cord-016523-pznw2ciu	61	40	/	/	SYM
cord-016523-pznw2ciu	61	41	receptor	receptor	NN
cord-016523-pznw2ciu	61	42	interactions	interaction	NNS
cord-016523-pznw2ciu	61	43	with	with	IN
cord-016523-pznw2ciu	61	44	neutralizing	neutralize	VBG
cord-016523-pznw2ciu	61	45	mAbs	mAbs	NNP
cord-016523-pznw2ciu	61	46	is	be	VBZ
cord-016523-pznw2ciu	61	47	an	an	DT
cord-016523-pznw2ciu	61	48	invaluable	invaluable	JJ
cord-016523-pznw2ciu	61	49	opportunity	opportunity	NN
cord-016523-pznw2ciu	61	50	to	to	TO
cord-016523-pznw2ciu	61	51	treat	treat	VB
cord-016523-pznw2ciu	61	52	certain	certain	JJ
cord-016523-pznw2ciu	61	53	chronic	chronic	JJ
cord-016523-pznw2ciu	61	54	infl	infl	NN
cord-016523-pznw2ciu	61	55	ammatory	ammatory	NN
cord-016523-pznw2ciu	61	56	disorders	disorder	NNS
cord-016523-pznw2ciu	61	57	.	.	.
cord-016523-pznw2ciu	62	1	Other	other	JJ
cord-016523-pznw2ciu	62	2	TNF	TNF	NNP
cord-016523-pznw2ciu	62	3	-	-	HYPH
cord-016523-pznw2ciu	62	4	α	α	NNP
cord-016523-pznw2ciu	62	5	antagonists	antagonist	NNS
cord-016523-pznw2ciu	62	6	,	,	,
cord-016523-pznw2ciu	62	7	such	such	JJ
cord-016523-pznw2ciu	62	8	as	as	IN
cord-016523-pznw2ciu	62	9	etanercept	etanercept	NNP
cord-016523-pznw2ciu	62	10	,	,	,
cord-016523-pznw2ciu	62	11	a	a	DT
cord-016523-pznw2ciu	62	12	TNFR2-immunoglobulin	TNFR2-immunoglobulin	NNP
cord-016523-pznw2ciu	62	13	Fc	Fc	NNP
cord-016523-pznw2ciu	62	14	fusion	fusion	NN
cord-016523-pznw2ciu	62	15	protein	protein	NN
cord-016523-pznw2ciu	62	16	,	,	,
cord-016523-pznw2ciu	62	17	can	can	MD
cord-016523-pznw2ciu	62	18	improve	improve	VB
cord-016523-pznw2ciu	62	19	the	the	DT
cord-016523-pznw2ciu	62	20	clinical	clinical	JJ
cord-016523-pznw2ciu	62	21	course	course	NN
cord-016523-pznw2ciu	62	22	of	of	IN
cord-016523-pznw2ciu	62	23	rheumatoid	rheumatoid	NN
cord-016523-pznw2ciu	62	24	arthritis	arthritis	NN
cord-016523-pznw2ciu	62	25	[	[	-LRB-
cord-016523-pznw2ciu	62	26	47	47	CD
cord-016523-pznw2ciu	62	27	]	]	-RRB-
cord-016523-pznw2ciu	62	28	.	.	.
cord-016523-pznw2ciu	63	1	While	while	IN
cord-016523-pznw2ciu	63	2	fi	fi	NNP
cord-016523-pznw2ciu	63	3	ndings	nding	NNS
cord-016523-pznw2ciu	63	4	accumulate	accumulate	VBP
cord-016523-pznw2ciu	63	5	to	to	TO
cord-016523-pznw2ciu	63	6	decipher	decipher	VB
cord-016523-pznw2ciu	63	7	the	the	DT
cord-016523-pznw2ciu	63	8	molecular	molecular	JJ
cord-016523-pznw2ciu	63	9	mechanisms	mechanism	NNS
cord-016523-pznw2ciu	63	10	involved	involve	VBN
cord-016523-pznw2ciu	63	11	in	in	IN
cord-016523-pznw2ciu	63	12	the	the	DT
cord-016523-pznw2ciu	63	13	induction	induction	NN
cord-016523-pznw2ciu	63	14	of	of	IN
cord-016523-pznw2ciu	63	15	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	63	16	and	and	CC
cord-016523-pznw2ciu	63	17	non	non	JJ
cord-016523-pznw2ciu	63	18	-	-	JJ
cord-016523-pznw2ciu	63	19	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	63	20	signaling	signal	VBG
cord-016523-pznw2ciu	63	21	pathways	pathway	NNS
cord-016523-pznw2ciu	63	22	by	by	IN
cord-016523-pznw2ciu	63	23	TNFR1	tnfr1	XX
cord-016523-pznw2ciu	63	24	and	and	CC
cord-016523-pznw2ciu	63	25	to	to	TO
cord-016523-pznw2ciu	63	26	elucidate	elucidate	VB
cord-016523-pznw2ciu	63	27	how	how	WRB
cord-016523-pznw2ciu	63	28	the	the	DT
cord-016523-pznw2ciu	63	29	receptor	receptor	NN
cord-016523-pznw2ciu	63	30	can	can	MD
cord-016523-pznw2ciu	63	31	switch	switch	VB
cord-016523-pznw2ciu	63	32	from	from	IN
cord-016523-pznw2ciu	63	33	one	one	CD
cord-016523-pznw2ciu	63	34	signal	signal	NN
cord-016523-pznw2ciu	63	35	to	to	IN
cord-016523-pznw2ciu	63	36	the	the	DT
cord-016523-pznw2ciu	63	37	other	other	JJ
cord-016523-pznw2ciu	63	38	,	,	,
cord-016523-pznw2ciu	63	39	the	the	DT
cord-016523-pznw2ciu	63	40	mechanistic	mechanistic	JJ
cord-016523-pznw2ciu	63	41	links	link	NNS
cord-016523-pznw2ciu	63	42	involved	involve	VBN
cord-016523-pznw2ciu	63	43	in	in	IN
cord-016523-pznw2ciu	63	44	the	the	DT
cord-016523-pznw2ciu	63	45	implementation	implementation	NN
cord-016523-pznw2ciu	63	46	of	of	IN
cord-016523-pznw2ciu	63	47	non	non	JJ
cord-016523-pznw2ciu	63	48	-	-	JJ
cord-016523-pznw2ciu	63	49	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	63	50	signaling	signal	VBG
cord-016523-pznw2ciu	63	51	pathways	pathway	NNS
cord-016523-pznw2ciu	63	52	by	by	IN
cord-016523-pznw2ciu	63	53	CD95	CD95	NNP
cord-016523-pznw2ciu	63	54	remain	remain	VBP
cord-016523-pznw2ciu	63	55	elusive	elusive	JJ
cord-016523-pznw2ciu	63	56	.	.	.
cord-016523-pznw2ciu	64	1	However	however	RB
cord-016523-pznw2ciu	64	2	,	,	,
cord-016523-pznw2ciu	64	3	recent	recent	JJ
cord-016523-pznw2ciu	64	4	fi	fi	NN
cord-016523-pznw2ciu	64	5	ndings	nding	NNS
cord-016523-pznw2ciu	64	6	have	have	VBP
cord-016523-pznw2ciu	64	7	revealed	reveal	VBN
cord-016523-pznw2ciu	64	8	its	-PRON-	PRP$
cord-016523-pznw2ciu	64	9	proinfl	proinfl	NN
cord-016523-pznw2ciu	64	10	ammatory	ammatory	NN
cord-016523-pznw2ciu	64	11	effects	effect	NNS
cord-016523-pznw2ciu	64	12	[	[	-LRB-
cord-016523-pznw2ciu	64	13	48	48	CD
cord-016523-pznw2ciu	64	14	-54	-54	NNS
cord-016523-pznw2ciu	64	15	]	]	-RRB-
cord-016523-pznw2ciu	64	16	.	.	.
cord-016523-pznw2ciu	65	1	In	in	IN
cord-016523-pznw2ciu	65	2	1989	1989	CD
cord-016523-pznw2ciu	65	3	,	,	,
cord-016523-pznw2ciu	65	4	identifi	identifi	NNP
cord-016523-pznw2ciu	65	5	cation	cation	NNP
cord-016523-pznw2ciu	65	6	of	of	IN
cord-016523-pznw2ciu	65	7	the	the	DT
cord-016523-pznw2ciu	65	8	mAb	mAb	NNP
cord-016523-pznw2ciu	65	9	APO-1	APO-1	NNP
cord-016523-pznw2ciu	65	10	by	by	IN
cord-016523-pznw2ciu	65	11	Peter	Peter	NNP
cord-016523-pznw2ciu	65	12	Krammer	Krammer	NNP
cord-016523-pznw2ciu	65	13	et	et	NNP
cord-016523-pznw2ciu	65	14	al	al	NNP
cord-016523-pznw2ciu	65	15	.	.	NNP
cord-016523-pznw2ciu	65	16	revealed	reveal	VBD
cord-016523-pznw2ciu	65	17	the	the	DT
cord-016523-pznw2ciu	65	18	existence	existence	NN
cord-016523-pznw2ciu	65	19	of	of	IN
cord-016523-pznw2ciu	65	20	a	a	DT
cord-016523-pznw2ciu	65	21	52	52	CD
cord-016523-pznw2ciu	65	22	kDa	kDa	NNP
cord-016523-pznw2ciu	65	23	protein	protein	NN
cord-016523-pznw2ciu	65	24	whose	whose	WP$
cord-016523-pznw2ciu	65	25	aggregation	aggregation	NN
cord-016523-pznw2ciu	65	26	was	be	VBD
cord-016523-pznw2ciu	65	27	able	able	JJ
cord-016523-pznw2ciu	65	28	to	to	TO
cord-016523-pznw2ciu	65	29	transmit	transmit	VB
cord-016523-pznw2ciu	65	30	an	an	DT
cord-016523-pznw2ciu	65	31	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	65	32	signal	signal	NN
cord-016523-pznw2ciu	65	33	in	in	IN
cord-016523-pznw2ciu	65	34	cancer	cancer	NN
cord-016523-pznw2ciu	65	35	cells	cell	NNS
cord-016523-pznw2ciu	65	36	[	[	-LRB-
cord-016523-pznw2ciu	65	37	55	55	CD
cord-016523-pznw2ciu	65	38	]	]	-RRB-
cord-016523-pznw2ciu	65	39	.	.	.
cord-016523-pznw2ciu	66	1	This	this	DT
cord-016523-pznw2ciu	66	2	receptor	receptor	NN
cord-016523-pznw2ciu	66	3	was	be	VBD
cord-016523-pznw2ciu	66	4	identifi	identifi	VBN
cord-016523-pznw2ciu	66	5	ed	ed	NNP
cord-016523-pznw2ciu	66	6	in	in	IN
cord-016523-pznw2ciu	66	7	1991	1991	CD
cord-016523-pznw2ciu	66	8	by	by	IN
cord-016523-pznw2ciu	66	9	Nagata	Nagata	NNP
cord-016523-pznw2ciu	66	10	and	and	CC
cord-016523-pznw2ciu	66	11	colleagues	colleague	NNS
cord-016523-pznw2ciu	66	12	and	and	CC
cord-016523-pznw2ciu	66	13	called	call	VBN
cord-016523-pznw2ciu	66	14	Fas	Fas	NNP
cord-016523-pznw2ciu	66	15	(	(	-LRB-
cord-016523-pznw2ciu	66	16	CD95	CD95	NNP
cord-016523-pznw2ciu	66	17	or	or	CC
cord-016523-pznw2ciu	66	18	APO-1	APO-1	NNP
cord-016523-pznw2ciu	66	19	)	)	-RRB-
cord-016523-pznw2ciu	67	1	[	[	-LRB-
cord-016523-pznw2ciu	67	2	12	12	CD
cord-016523-pznw2ciu	67	3	]	]	-RRB-
cord-016523-pznw2ciu	67	4	.	.	.
cord-016523-pznw2ciu	68	1	Its	-PRON-	PRP$
cord-016523-pznw2ciu	68	2	ligand	ligand	NN
cord-016523-pznw2ciu	68	3	,	,	,
cord-016523-pznw2ciu	68	4	FasL	FasL	NNP
cord-016523-pznw2ciu	68	5	,	,	,
cord-016523-pznw2ciu	68	6	was	be	VBD
cord-016523-pznw2ciu	68	7	cloned	clone	VBN
cord-016523-pznw2ciu	68	8	in	in	IN
cord-016523-pznw2ciu	68	9	1993	1993	CD
cord-016523-pznw2ciu	68	10	by	by	IN
cord-016523-pznw2ciu	68	11	the	the	DT
cord-016523-pznw2ciu	68	12	same	same	JJ
cord-016523-pznw2ciu	68	13	group	group	NN
cord-016523-pznw2ciu	68	14	and	and	CC
cord-016523-pznw2ciu	68	15	was	be	VBD
cord-016523-pznw2ciu	68	16	found	find	VBN
cord-016523-pznw2ciu	68	17	to	to	TO
cord-016523-pznw2ciu	68	18	be	be	VB
cord-016523-pznw2ciu	68	19	mainly	mainly	RB
cord-016523-pznw2ciu	68	20	expressed	express	VBN
cord-016523-pznw2ciu	68	21	at	at	IN
cord-016523-pznw2ciu	68	22	the	the	DT
cord-016523-pznw2ciu	68	23	surface	surface	NN
cord-016523-pznw2ciu	68	24	of	of	IN
cord-016523-pznw2ciu	68	25	activated	activate	VBN
cord-016523-pznw2ciu	68	26	T	t	NN
cord-016523-pznw2ciu	68	27	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	68	28	[	[	-LRB-
cord-016523-pznw2ciu	68	29	56	56	CD
cord-016523-pznw2ciu	68	30	]	]	-RRB-
cord-016523-pznw2ciu	68	31	and	and	CC
cord-016523-pznw2ciu	68	32	natural	natural	JJ
cord-016523-pznw2ciu	68	33	killer	killer	NN
cord-016523-pznw2ciu	68	34	(	(	-LRB-
cord-016523-pznw2ciu	68	35	NK	NK	NNP
cord-016523-pznw2ciu	68	36	)	)	-RRB-
cord-016523-pznw2ciu	68	37	cells	cell	NNS
cord-016523-pznw2ciu	68	38	[	[	-LRB-
cord-016523-pznw2ciu	68	39	57	57	CD
cord-016523-pznw2ciu	68	40	]	]	-RRB-
cord-016523-pznw2ciu	68	41	;	;	:
cord-016523-pznw2ciu	68	42	however	however	RB
cord-016523-pznw2ciu	68	43	,	,	,
cord-016523-pznw2ciu	68	44	its	-PRON-	PRP$
cord-016523-pznw2ciu	68	45	expression	expression	NN
cord-016523-pznw2ciu	68	46	was	be	VBD
cord-016523-pznw2ciu	68	47	also	also	RB
cord-016523-pznw2ciu	68	48	detected	detect	VBN
cord-016523-pznw2ciu	68	49	in	in	IN
cord-016523-pznw2ciu	68	50	different	different	JJ
cord-016523-pznw2ciu	68	51	tissues	tissue	NNS
cord-016523-pznw2ciu	68	52	in	in	IN
cord-016523-pznw2ciu	68	53	which	which	WDT
cord-016523-pznw2ciu	68	54	the	the	DT
cord-016523-pznw2ciu	68	55	presence	presence	NN
cord-016523-pznw2ciu	68	56	of	of	IN
cord-016523-pznw2ciu	68	57	acute	acute	JJ
cord-016523-pznw2ciu	68	58	or	or	CC
cord-016523-pznw2ciu	68	59	chronic	chronic	JJ
cord-016523-pznw2ciu	68	60	infl	infl	NN
cord-016523-pznw2ciu	68	61	ammation	ammation	NN
cord-016523-pznw2ciu	68	62	is	be	VBZ
cord-016523-pznw2ciu	68	63	undesirable	undesirable	JJ
cord-016523-pznw2ciu	68	64	including	include	VBG
cord-016523-pznw2ciu	68	65	the	the	DT
cord-016523-pznw2ciu	68	66	eyes	eye	NNS
cord-016523-pznw2ciu	68	67	[	[	-LRB-
cord-016523-pznw2ciu	68	68	58	58	CD
cord-016523-pznw2ciu	68	69	]	]	-RRB-
cord-016523-pznw2ciu	68	70	and	and	CC
cord-016523-pznw2ciu	68	71	testes	testis	NNS
cord-016523-pznw2ciu	68	72	[	[	-LRB-
cord-016523-pznw2ciu	68	73	59	59	CD
cord-016523-pznw2ciu	68	74	]	]	-RRB-
cord-016523-pznw2ciu	68	75	.	.	.
cord-016523-pznw2ciu	69	1	In	in	IN
cord-016523-pznw2ciu	69	2	addition	addition	NN
cord-016523-pznw2ciu	69	3	,	,	,
cord-016523-pznw2ciu	69	4	two	two	CD
cord-016523-pznw2ciu	69	5	mouse	mouse	NN
cord-016523-pznw2ciu	69	6	models	model	NNS
cord-016523-pznw2ciu	69	7	,	,	,
cord-016523-pznw2ciu	69	8	in	in	IN
cord-016523-pznw2ciu	69	9	which	which	WDT
cord-016523-pznw2ciu	69	10	either	either	CC
cord-016523-pznw2ciu	69	11	the	the	DT
cord-016523-pznw2ciu	69	12	level	level	NN
cord-016523-pznw2ciu	69	13	of	of	IN
cord-016523-pznw2ciu	69	14	CD95	CD95	NNP
cord-016523-pznw2ciu	69	15	expression	expression	NN
cord-016523-pznw2ciu	69	16	was	be	VBD
cord-016523-pznw2ciu	69	17	downregulated	downregulate	VBN
cord-016523-pznw2ciu	69	18	[	[	-LRB-
cord-016523-pznw2ciu	69	19	due	due	IN
cord-016523-pznw2ciu	69	20	to	to	IN
cord-016523-pznw2ciu	69	21	an	an	DT
cord-016523-pznw2ciu	69	22	insertion	insertion	NN
cord-016523-pznw2ciu	69	23	of	of	IN
cord-016523-pznw2ciu	69	24	a	a	DT
cord-016523-pznw2ciu	69	25	retrotransposon	retrotransposon	NN
cord-016523-pznw2ciu	69	26	in	in	IN
cord-016523-pznw2ciu	69	27	intron	intron	NN
cord-016523-pznw2ciu	69	28	2	2	CD
cord-016523-pznw2ciu	69	29	of	of	IN
cord-016523-pznw2ciu	69	30	the	the	DT
cord-016523-pznw2ciu	69	31	receptor	receptor	NN
cord-016523-pznw2ciu	69	32	gene	gene	NN
cord-016523-pznw2ciu	69	33	,	,	,
cord-016523-pznw2ciu	69	34	these	these	DT
cord-016523-pznw2ciu	69	35	mice	mouse	NNS
cord-016523-pznw2ciu	69	36	are	be	VBP
cord-016523-pznw2ciu	69	37	called	call	VBN
cord-016523-pznw2ciu	69	38	lymphoproliferation	lymphoproliferation	NN
cord-016523-pznw2ciu	70	1	(	(	-LRB-
cord-016523-pznw2ciu	70	2	Lpr	Lpr	NNP
cord-016523-pznw2ciu	70	3	)	)	-RRB-
cord-016523-pznw2ciu	71	1	[	[	-LRB-
cord-016523-pznw2ciu	71	2	60	60	CD
cord-016523-pznw2ciu	71	3	-62	-62	NN
cord-016523-pznw2ciu	71	4	]	]	-RRB-
cord-016523-pznw2ciu	71	5	 	 	_SP
cord-016523-pznw2ciu	72	1	The	the	DT
cord-016523-pznw2ciu	72	2	CD95	CD95	NNP
cord-016523-pznw2ciu	72	3	gene	gene	NN
cord-016523-pznw2ciu	72	4	(	(	-LRB-
cord-016523-pznw2ciu	72	5	APT	APT	NNP
cord-016523-pznw2ciu	72	6	-1	-1	NN
cord-016523-pznw2ciu	72	7	)	)	-RRB-
cord-016523-pznw2ciu	72	8	consists	consist	VBZ
cord-016523-pznw2ciu	72	9	of	of	IN
cord-016523-pznw2ciu	72	10	nine	nine	CD
cord-016523-pznw2ciu	72	11	exons	exon	NNS
cord-016523-pznw2ciu	72	12	,	,	,
cord-016523-pznw2ciu	72	13	with	with	IN
cord-016523-pznw2ciu	72	14	exon	exon	NN
cord-016523-pznw2ciu	72	15	6	6	CD
cord-016523-pznw2ciu	72	16	encoding	encode	VBG
cord-016523-pznw2ciu	72	17	the	the	DT
cord-016523-pznw2ciu	72	18	transmembrane	transmembrane	NN
cord-016523-pznw2ciu	72	19	domain	domain	NN
cord-016523-pznw2ciu	72	20	[	[	-LRB-
cord-016523-pznw2ciu	72	21	66	66	CD
cord-016523-pznw2ciu	72	22	]	]	-RRB-
cord-016523-pznw2ciu	73	1	(	(	-LRB-
cord-016523-pznw2ciu	73	2	Fig	Fig	NNP
cord-016523-pznw2ciu	73	3	.	.	.
cord-016523-pznw2ciu	73	4	9.1	9.1	CD
cord-016523-pznw2ciu	73	5	)	)	-RRB-
cord-016523-pznw2ciu	73	6	.	.	.
cord-016523-pznw2ciu	74	1	CD95	CD95	NNP
cord-016523-pznw2ciu	74	2	can	can	MD
cord-016523-pznw2ciu	74	3	be	be	VB
cord-016523-pznw2ciu	74	4	resolved	resolve	VBN
cord-016523-pznw2ciu	74	5	under	under	IN
cord-016523-pznw2ciu	74	6	denaturing	denaturing	JJ
cord-016523-pznw2ciu	74	7	conditions	condition	NNS
cord-016523-pznw2ciu	74	8	between	between	IN
cord-016523-pznw2ciu	74	9	40	40	CD
cord-016523-pznw2ciu	74	10	and	and	CC
cord-016523-pznw2ciu	74	11	50	50	CD
cord-016523-pznw2ciu	74	12	kDa	kDa	NNS
cord-016523-pznw2ciu	74	13	by	by	IN
cord-016523-pznw2ciu	74	14	SDS	SDS	NNP
cord-016523-pznw2ciu	74	15	-	-	HYPH
cord-016523-pznw2ciu	74	16	PAGE	PAGE	NNP
cord-016523-pznw2ciu	74	17	.	.	.
cord-016523-pznw2ciu	75	1	The	the	DT
cord-016523-pznw2ciu	75	2	receptor	receptor	NN
cord-016523-pznw2ciu	75	3	is	be	VBZ
cord-016523-pznw2ciu	75	4	a	a	DT
cord-016523-pznw2ciu	75	5	type	type	NN
cord-016523-pznw2ciu	75	6	I	-PRON-	PRP
cord-016523-pznw2ciu	75	7	transmembrane	transmembrane	NN
cord-016523-pznw2ciu	75	8	protein	protein	NN
cord-016523-pznw2ciu	75	9	harboring	harbor	VBG
cord-016523-pznw2ciu	75	10	three	three	CD
cord-016523-pznw2ciu	75	11	CRDs	crd	NNS
cord-016523-pznw2ciu	75	12	.	.	.
cord-016523-pznw2ciu	76	1	Similar	similar	JJ
cord-016523-pznw2ciu	76	2	to	to	IN
cord-016523-pznw2ciu	76	3	the	the	DT
cord-016523-pznw2ciu	76	4	TNF	TNF	NNP
cord-016523-pznw2ciu	76	5	receptor	receptor	NN
cord-016523-pznw2ciu	76	6	[	[	-LRB-
cord-016523-pznw2ciu	76	7	29	29	CD
cord-016523-pznw2ciu	76	8	]	]	-RRB-
cord-016523-pznw2ciu	76	9	,	,	,
cord-016523-pznw2ciu	76	10	CD95	CD95	NNP
cord-016523-pznw2ciu	76	11	is	be	VBZ
cord-016523-pznw2ciu	76	12	preassociated	preassociate	VBN
cord-016523-pznw2ciu	76	13	at	at	IN
cord-016523-pznw2ciu	76	14	the	the	DT
cord-016523-pznw2ciu	76	15	plasma	plasma	NN
cord-016523-pznw2ciu	76	16	membrane	membrane	NN
cord-016523-pznw2ciu	76	17	as	as	IN
cord-016523-pznw2ciu	76	18	a	a	DT
cord-016523-pznw2ciu	76	19	homotrimer	homotrimer	NN
cord-016523-pznw2ciu	76	20	,	,	,
cord-016523-pznw2ciu	76	21	and	and	CC
cord-016523-pznw2ciu	76	22	this	this	DT
cord-016523-pznw2ciu	76	23	quaternary	quaternary	JJ
cord-016523-pznw2ciu	76	24	structure	structure	NN
cord-016523-pznw2ciu	76	25	is	be	VBZ
cord-016523-pznw2ciu	76	26	mandatory	mandatory	JJ
cord-016523-pznw2ciu	76	27	for	for	IN
cord-016523-pznw2ciu	76	28	transmission	transmission	NN
cord-016523-pznw2ciu	76	29	of	of	IN
cord-016523-pznw2ciu	76	30	the	the	DT
cord-016523-pznw2ciu	76	31	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	76	32	signals	signal	NNS
cord-016523-pznw2ciu	76	33	in	in	IN
cord-016523-pznw2ciu	76	34	the	the	DT
cord-016523-pznw2ciu	76	35	presence	presence	NN
cord-016523-pznw2ciu	76	36	of	of	IN
cord-016523-pznw2ciu	76	37	CD95L	CD95L	NNP
cord-016523-pznw2ciu	76	38	[	[	-LRB-
cord-016523-pznw2ciu	76	39	23	23	CD
cord-016523-pznw2ciu	76	40	,	,	,
cord-016523-pznw2ciu	76	41	24	24	CD
cord-016523-pznw2ciu	76	42	]	]	-RRB-
cord-016523-pznw2ciu	76	43	.	.	.
cord-016523-pznw2ciu	77	1	Homotrimerization	Homotrimerization	NNP
cord-016523-pznw2ciu	77	2	of	of	IN
cord-016523-pznw2ciu	77	3	CD95	CD95	NNP
cord-016523-pznw2ciu	77	4	occurs	occur	VBZ
cord-016523-pznw2ciu	77	5	mainly	mainly	RB
cord-016523-pznw2ciu	77	6	through	through	IN
cord-016523-pznw2ciu	77	7	homotypic	homotypic	JJ
cord-016523-pznw2ciu	77	8	interactions	interaction	NNS
cord-016523-pznw2ciu	77	9	of	of	IN
cord-016523-pznw2ciu	77	10	the	the	DT
cord-016523-pznw2ciu	77	11	CD95-CRD1	CD95-CRD1	NNP
cord-016523-pznw2ciu	77	12	[	[	-LRB-
cord-016523-pznw2ciu	77	13	22	22	CD
cord-016523-pznw2ciu	77	14	-24	-24	NN
cord-016523-pznw2ciu	77	15	]	]	-RRB-
cord-016523-pznw2ciu	77	16	.	.	.
cord-016523-pznw2ciu	78	1	Binding	bind	VBG
cord-016523-pznw2ciu	78	2	of	of	IN
cord-016523-pznw2ciu	78	3	CD95L	cd95l	NN
cord-016523-pznw2ciu	78	4	or	or	CC
cord-016523-pznw2ciu	78	5	agonistic	agonistic	JJ
cord-016523-pznw2ciu	78	6	anti	anti	JJ
cord-016523-pznw2ciu	78	7	-	-	NNP
cord-016523-pznw2ciu	78	8	CD95	CD95	NNP
cord-016523-pznw2ciu	78	9	mAbs	mabs	NN
cord-016523-pznw2ciu	78	10	to	to	IN
cord-016523-pznw2ciu	78	11	CD95	CD95	NNP
cord-016523-pznw2ciu	78	12	alters	alter	VBZ
cord-016523-pznw2ciu	78	13	both	both	PDT
cord-016523-pznw2ciu	78	14	the	the	DT
cord-016523-pznw2ciu	78	15	conformation	conformation	NN
cord-016523-pznw2ciu	78	16	and	and	CC
cord-016523-pznw2ciu	78	17	the	the	DT
cord-016523-pznw2ciu	78	18	extent	extent	NN
cord-016523-pznw2ciu	78	19	to	to	TO
cord-016523-pznw2ciu	78	20	which	which	WDT
cord-016523-pznw2ciu	78	21	the	the	DT
cord-016523-pznw2ciu	78	22	receptor	receptor	NN
cord-016523-pznw2ciu	78	23	is	be	VBZ
cord-016523-pznw2ciu	78	24	multimerized	multimerize	VBN
cord-016523-pznw2ciu	78	25	at	at	IN
cord-016523-pznw2ciu	78	26	the	the	DT
cord-016523-pznw2ciu	78	27	plasma	plasma	NN
cord-016523-pznw2ciu	78	28	membrane	membrane	NN
cord-016523-pznw2ciu	78	29	.	.	.
cord-016523-pznw2ciu	79	1	The	the	DT
cord-016523-pznw2ciu	79	2	intracellular	intracellular	JJ
cord-016523-pznw2ciu	79	3	region	region	NN
cord-016523-pznw2ciu	79	4	of	of	IN
cord-016523-pznw2ciu	79	5	CD95	CD95	NNP
cord-016523-pznw2ciu	79	6	encompasses	encompass	VBZ
cord-016523-pznw2ciu	79	7	an	an	DT
cord-016523-pznw2ciu	79	8	80	80	CD
cord-016523-pznw2ciu	79	9	amino	amino	NN
cord-016523-pznw2ciu	79	10	acid	acid	NN
cord-016523-pznw2ciu	79	11	stretch	stretch	NN
cord-016523-pznw2ciu	79	12	designated	designate	VBN
cord-016523-pznw2ciu	79	13	as	as	IN
cord-016523-pznw2ciu	79	14	the	the	DT
cord-016523-pznw2ciu	79	15	DD	DD	NNP
cord-016523-pznw2ciu	79	16	(	(	-LRB-
cord-016523-pznw2ciu	79	17	Fig	fig	NN
cord-016523-pznw2ciu	79	18	.	.	.
cord-016523-pznw2ciu	79	19	9	9	CD
cord-016523-pznw2ciu	79	20	.1	.1	CD
cord-016523-pznw2ciu	79	21	)	)	-RRB-
cord-016523-pznw2ciu	79	22	,	,	,
cord-016523-pznw2ciu	79	23	which	which	WDT
cord-016523-pznw2ciu	79	24	consists	consist	VBZ
cord-016523-pznw2ciu	79	25	of	of	IN
cord-016523-pznw2ciu	79	26	six	six	CD
cord-016523-pznw2ciu	79	27	antiparallel	antiparallel	NN
cord-016523-pznw2ciu	79	28	α	α	NN
cord-016523-pznw2ciu	79	29	-	-	HYPH
cord-016523-pznw2ciu	79	30	helices	helix	NNS
cord-016523-pznw2ciu	79	31	[	[	-LRB-
cord-016523-pznw2ciu	79	32	67	67	CD
cord-016523-pznw2ciu	79	33	]	]	-RRB-
cord-016523-pznw2ciu	79	34	.	.	.
cord-016523-pznw2ciu	80	1	Upon	upon	IN
cord-016523-pznw2ciu	80	2	addition	addition	NN
cord-016523-pznw2ciu	80	3	of	of	IN
cord-016523-pznw2ciu	80	4	CD95L	cd95l	NN
cord-016523-pznw2ciu	80	5	,	,	,
cord-016523-pznw2ciu	80	6	CD95	CD95	NNP
cord-016523-pznw2ciu	80	7	undergoes	undergo	VBZ
cord-016523-pznw2ciu	80	8	conformational	conformational	JJ
cord-016523-pznw2ciu	80	9	modifi	modifi	JJ
cord-016523-pznw2ciu	80	10	cation	cation	NN
cord-016523-pznw2ciu	80	11	of	of	IN
cord-016523-pznw2ciu	80	12	its	-PRON-	PRP$
cord-016523-pznw2ciu	80	13	DD	DD	NNP
cord-016523-pznw2ciu	80	14	,	,	,
cord-016523-pznw2ciu	80	15	which	which	WDT
cord-016523-pznw2ciu	80	16	induces	induce	VBZ
cord-016523-pznw2ciu	80	17	a	a	DT
cord-016523-pznw2ciu	80	18	shift	shift	NN
cord-016523-pznw2ciu	80	19	of	of	IN
cord-016523-pznw2ciu	80	20	helix	helix	NN
cord-016523-pznw2ciu	80	21	6	6	CD
cord-016523-pznw2ciu	80	22	and	and	CC
cord-016523-pznw2ciu	80	23	fusion	fusion	NN
cord-016523-pznw2ciu	80	24	with	with	IN
cord-016523-pznw2ciu	80	25	helix	helix	NN
cord-016523-pznw2ciu	80	26	5	5	CD
cord-016523-pznw2ciu	80	27	,	,	,
cord-016523-pznw2ciu	80	28	promoting	promote	VBG
cord-016523-pznw2ciu	80	29	both	both	DT
cord-016523-pznw2ciu	80	30	oligomerization	oligomerization	NN
cord-016523-pznw2ciu	80	31	of	of	IN
cord-016523-pznw2ciu	80	32	the	the	DT
cord-016523-pznw2ciu	80	33	receptor	receptor	NN
cord-016523-pznw2ciu	80	34	and	and	CC
cord-016523-pznw2ciu	80	35	recruitment	recruitment	NN
cord-016523-pznw2ciu	80	36	of	of	IN
cord-016523-pznw2ciu	80	37	the	the	DT
cord-016523-pznw2ciu	80	38	adaptor	adaptor	NN
cord-016523-pznw2ciu	80	39	protein	protein	NN
cord-016523-pznw2ciu	80	40	FADD	FADD	NNP
cord-016523-pznw2ciu	80	41	[	[	-LRB-
cord-016523-pznw2ciu	80	42	68	68	CD
cord-016523-pznw2ciu	80	43	]	]	-RRB-
cord-016523-pznw2ciu	80	44	.	.	.
cord-016523-pznw2ciu	81	1	A	a	DT
cord-016523-pznw2ciu	81	2	consequence	consequence	NN
cord-016523-pznw2ciu	81	3	of	of	IN
cord-016523-pznw2ciu	81	4	the	the	DT
cord-016523-pznw2ciu	81	5	opening	opening	NN
cord-016523-pznw2ciu	81	6	of	of	IN
cord-016523-pznw2ciu	81	7	the	the	DT
cord-016523-pznw2ciu	81	8	globular	globular	JJ
cord-016523-pznw2ciu	81	9	structure	structure	NN
cord-016523-pznw2ciu	81	10	of	of	IN
cord-016523-pznw2ciu	81	11	CD95	CD95	NNP
cord-016523-pznw2ciu	81	12	is	be	VBZ
cord-016523-pznw2ciu	81	13	that	that	IN
cord-016523-pznw2ciu	81	14	the	the	DT
cord-016523-pznw2ciu	81	15	receptor	receptor	NN
cord-016523-pznw2ciu	81	16	becomes	become	VBZ
cord-016523-pznw2ciu	81	17	connected	connect	VBN
cord-016523-pznw2ciu	81	18	through	through	IN
cord-016523-pznw2ciu	81	19	this	this	DT
cord-016523-pznw2ciu	81	20	bridge	bridge	NN
cord-016523-pznw2ciu	81	21	,	,	,
cord-016523-pznw2ciu	81	22	which	which	WDT
cord-016523-pznw2ciu	81	23	increases	increase	VBZ
cord-016523-pznw2ciu	81	24	the	the	DT
cord-016523-pznw2ciu	81	25	magnitude	magnitude	NN
cord-016523-pznw2ciu	81	26	of	of	IN
cord-016523-pznw2ciu	81	27	its	-PRON-	PRP$
cord-016523-pznw2ciu	81	28	homo	homo	NN
cord-016523-pznw2ciu	81	29	-	-	HYPH
cord-016523-pznw2ciu	81	30	aggregation	aggregation	NN
cord-016523-pznw2ciu	81	31	.	.	.
cord-016523-pznw2ciu	82	1	This	this	DT
cord-016523-pznw2ciu	82	2	long	long	JJ
cord-016523-pznw2ciu	82	3	helix	helix	NN
cord-016523-pznw2ciu	82	4	allows	allow	VBZ
cord-016523-pznw2ciu	82	5	the	the	DT
cord-016523-pznw2ciu	82	6	stabilization	stabilization	NN
cord-016523-pznw2ciu	82	7	of	of	IN
cord-016523-pznw2ciu	82	8	the	the	DT
cord-016523-pznw2ciu	82	9	complex	complex	NN
cord-016523-pznw2ciu	82	10	by	by	IN
cord-016523-pznw2ciu	82	11	recruiting	recruit	VBG
cord-016523-pznw2ciu	82	12	FADD	FADD	NNP
cord-016523-pznw2ciu	82	13	.	.	.
cord-016523-pznw2ciu	83	1	Overall	overall	RB
cord-016523-pznw2ciu	83	2	,	,	,
cord-016523-pznw2ciu	83	3	the	the	DT
cord-016523-pznw2ciu	83	4	CD95-DD	cd95-dd	NN
cord-016523-pznw2ciu	83	5	:	:	:
cord-016523-pznw2ciu	83	6	FADD	FADD	NNP
cord-016523-pznw2ciu	83	7	-	-	HYPH
cord-016523-pznw2ciu	83	8	DD	DD	NNP
cord-016523-pznw2ciu	83	9	crystal	crystal	NN
cord-016523-pznw2ciu	83	10	structure	structure	NN
cord-016523-pznw2ciu	83	11	provides	provide	VBZ
cord-016523-pznw2ciu	83	12	some	some	DT
cord-016523-pznw2ciu	83	13	insights	insight	NNS
cord-016523-pznw2ciu	83	14	into	into	IN
cord-016523-pznw2ciu	83	15	the	the	DT
cord-016523-pznw2ciu	83	16	formation	formation	NN
cord-016523-pznw2ciu	83	17	of	of	IN
cord-016523-pznw2ciu	83	18	the	the	DT
cord-016523-pznw2ciu	83	19	large	large	JJ
cord-016523-pznw2ciu	83	20	CD95	CD95	NNP
cord-016523-pznw2ciu	83	21	clusters	cluster	NNS
cord-016523-pznw2ciu	83	22	observed	observe	VBD
cord-016523-pznw2ciu	83	23	using	use	VBG
cord-016523-pznw2ciu	83	24	imaging	image	VBG
cord-016523-pznw2ciu	83	25	or	or	CC
cord-016523-pznw2ciu	83	26	biochemical	biochemical	JJ
cord-016523-pznw2ciu	83	27	methods	method	NNS
cord-016523-pznw2ciu	83	28	in	in	IN
cord-016523-pznw2ciu	83	29	cells	cell	NNS
cord-016523-pznw2ciu	83	30	stimulated	stimulate	VBN
cord-016523-pznw2ciu	83	31	with	with	IN
cord-016523-pznw2ciu	83	32	CD95L.	CD95L.	NNP
cord-016523-pznw2ciu	84	1	In	in	IN
cord-016523-pznw2ciu	84	2	addition	addition	NN
cord-016523-pznw2ciu	84	3	,	,	,
cord-016523-pznw2ciu	84	4	it	-PRON-	PRP
cord-016523-pznw2ciu	84	5	also	also	RB
cord-016523-pznw2ciu	84	6	confi	confi	VBD
cord-016523-pznw2ciu	84	7	rms	rms	NNP
cord-016523-pznw2ciu	84	8	that	that	IN
cord-016523-pznw2ciu	84	9	alteration	alteration	NN
cord-016523-pznw2ciu	84	10	in	in	IN
cord-016523-pznw2ciu	84	11	the	the	DT
cord-016523-pznw2ciu	84	12	CD95	CD95	NNP
cord-016523-pznw2ciu	84	13	conformation	conformation	NN
cord-016523-pznw2ciu	84	14	plays	play	VBZ
cord-016523-pznw2ciu	84	15	an	an	DT
cord-016523-pznw2ciu	84	16	instrumental	instrumental	JJ
cord-016523-pznw2ciu	84	17	role	role	NN
cord-016523-pznw2ciu	84	18	during	during	IN
cord-016523-pznw2ciu	84	19	signal	signal	NN
cord-016523-pznw2ciu	84	20	induction	induction	NN
cord-016523-pznw2ciu	85	1	[	[	-LRB-
cord-016523-pznw2ciu	85	2	68	68	CD
cord-016523-pznw2ciu	85	3	]	]	-RRB-
cord-016523-pznw2ciu	86	1	However	however	RB
cord-016523-pznw2ciu	86	2	,	,	,
cord-016523-pznw2ciu	86	3	this	this	DT
cord-016523-pznw2ciu	86	4	elongated	elongated	JJ
cord-016523-pznw2ciu	86	5	C	c	NN
cord-016523-pznw2ciu	86	6	-	-	HYPH
cord-016523-pznw2ciu	86	7	terminal	terminal	NN
cord-016523-pznw2ciu	86	8	α	α	NN
cord-016523-pznw2ciu	86	9	-	-	HYPH
cord-016523-pznw2ciu	86	10	helix	helix	NN
cord-016523-pznw2ciu	86	11	favoring	favor	VBG
cord-016523-pznw2ciu	86	12	the	the	DT
cord-016523-pznw2ciu	86	13	cis	cis	NNP
cord-016523-pznw2ciu	86	14	-dimerization	-dimerization	NN
cord-016523-pznw2ciu	87	1	of	of	IN
cord-016523-pznw2ciu	87	2	CD95-DD	CD95-DD	NNP
cord-016523-pznw2ciu	87	3	was	be	VBD
cord-016523-pznw2ciu	87	4	challenged	challenge	VBN
cord-016523-pznw2ciu	87	5	by	by	IN
cord-016523-pznw2ciu	87	6	Driscoll	Driscoll	NNP
cord-016523-pznw2ciu	87	7	et	et	NNP
cord-016523-pznw2ciu	87	8	al	al	NNP
cord-016523-pznw2ciu	87	9	.	.	.
cord-016523-pznw2ciu	88	1	who	who	WP
cord-016523-pznw2ciu	88	2	did	do	VBD
cord-016523-pznw2ciu	88	3	not	not	RB
cord-016523-pznw2ciu	88	4	observe	observe	VB
cord-016523-pznw2ciu	88	5	the	the	DT
cord-016523-pznw2ciu	88	6	fusion	fusion	NN
cord-016523-pznw2ciu	88	7	of	of	IN
cord-016523-pznw2ciu	88	8	the	the	DT
cord-016523-pznw2ciu	88	9	last	last	JJ
cord-016523-pznw2ciu	88	10	two	two	CD
cord-016523-pznw2ciu	88	11	helices	helix	NNS
cord-016523-pznw2ciu	88	12	at	at	IN
cord-016523-pznw2ciu	88	13	a	a	DT
cord-016523-pznw2ciu	88	14	more	more	RBR
cord-016523-pznw2ciu	88	15	neutral	neutral	JJ
cord-016523-pznw2ciu	88	16	pH	ph	NN
cord-016523-pznw2ciu	88	17	(	(	-LRB-
cord-016523-pznw2ciu	88	18	pH	pH	NNP
cord-016523-pznw2ciu	88	19	6.2	6.2	CD
cord-016523-pznw2ciu	88	20	)	)	-RRB-
cord-016523-pznw2ciu	88	21	,	,	,
cord-016523-pznw2ciu	88	22	compared	compare	VBN
cord-016523-pznw2ciu	88	23	to	to	IN
cord-016523-pznw2ciu	88	24	the	the	DT
cord-016523-pznw2ciu	88	25	acidic	acidic	JJ
cord-016523-pznw2ciu	88	26	condition	condition	NN
cord-016523-pznw2ciu	88	27	(	(	-LRB-
cord-016523-pznw2ciu	88	28	pH	pH	NNP
cord-016523-pznw2ciu	88	29	4	4	CD
cord-016523-pznw2ciu	88	30	)	)	-RRB-
cord-016523-pznw2ciu	88	31	used	use	VBN
cord-016523-pznw2ciu	88	32	in	in	IN
cord-016523-pznw2ciu	88	33	the	the	DT
cord-016523-pznw2ciu	88	34	initial	initial	JJ
cord-016523-pznw2ciu	88	35	study	study	NN
cord-016523-pznw2ciu	88	36	to	to	TO
cord-016523-pznw2ciu	88	37	resolve	resolve	VB
cord-016523-pznw2ciu	88	38	the	the	DT
cord-016523-pznw2ciu	88	39	CD95-DD	cd95-dd	NN
cord-016523-pznw2ciu	88	40	:	:	:
cord-016523-pznw2ciu	88	41	FADD	FADD	NNP
cord-016523-pznw2ciu	88	42	-	-	HYPH
cord-016523-pznw2ciu	88	43	DD	DD	NNP
cord-016523-pznw2ciu	88	44	structure	structure	NN
cord-016523-pznw2ciu	88	45	[	[	-LRB-
cord-016523-pznw2ciu	88	46	68	68	CD
cord-016523-pznw2ciu	88	47	]	]	-RRB-
cord-016523-pznw2ciu	88	48	.	.	.
cord-016523-pznw2ciu	89	1	Consequently	consequently	RB
cord-016523-pznw2ciu	89	2	,	,	,
cord-016523-pznw2ciu	89	3	at	at	IN
cord-016523-pznw2ciu	89	4	pH	pH	NNP
cord-016523-pznw2ciu	89	5	6.2	6.2	CD
cord-016523-pznw2ciu	89	6	,	,	,
cord-016523-pznw2ciu	89	7	association	association	NN
cord-016523-pznw2ciu	89	8	of	of	IN
cord-016523-pznw2ciu	89	9	CD95	CD95	NNP
cord-016523-pznw2ciu	89	10	with	with	IN
cord-016523-pznw2ciu	89	11	FADD	FADD	NNP
cord-016523-pznw2ciu	89	12	predominantly	predominantly	RB
cord-016523-pznw2ciu	89	13	consisted	consist	VBD
cord-016523-pznw2ciu	89	14	of	of	IN
cord-016523-pznw2ciu	89	15	a	a	DT
cord-016523-pznw2ciu	89	16	5:5	5:5	CD
cord-016523-pznw2ciu	89	17	complex	complex	NN
cord-016523-pznw2ciu	89	18	,	,	,
cord-016523-pznw2ciu	89	19	which	which	WDT
cord-016523-pznw2ciu	89	20	occurred	occur	VBD
cord-016523-pznw2ciu	89	21	via	via	IN
cord-016523-pznw2ciu	89	22	a	a	DT
cord-016523-pznw2ciu	89	23	polymerization	polymerization	NN
cord-016523-pznw2ciu	89	24	mechanism	mechanism	NN
cord-016523-pznw2ciu	89	25	involving	involve	VBG
cord-016523-pznw2ciu	89	26	three	three	CD
cord-016523-pznw2ciu	89	27	types	type	NNS
cord-016523-pznw2ciu	89	28	of	of	IN
cord-016523-pznw2ciu	89	29	asymmetric	asymmetric	JJ
cord-016523-pznw2ciu	89	30	interactions	interaction	NNS
cord-016523-pznw2ciu	89	31	but	but	CC
cord-016523-pznw2ciu	89	32	without	without	IN
cord-016523-pznw2ciu	89	33	major	major	JJ
cord-016523-pznw2ciu	89	34	alteration	alteration	NN
cord-016523-pznw2ciu	89	35	of	of	IN
cord-016523-pznw2ciu	89	36	the	the	DT
cord-016523-pznw2ciu	89	37	DD	DD	NNP
cord-016523-pznw2ciu	89	38	globular	globular	JJ
cord-016523-pznw2ciu	89	39	structure	structure	NN
cord-016523-pznw2ciu	89	40	[	[	-LRB-
cord-016523-pznw2ciu	89	41	69	69	CD
cord-016523-pznw2ciu	89	42	,	,	,
cord-016523-pznw2ciu	89	43	70	70	CD
cord-016523-pznw2ciu	89	44	]	]	-RRB-
cord-016523-pznw2ciu	89	45	.	.	.
cord-016523-pznw2ciu	90	1	It	-PRON-	PRP
cord-016523-pznw2ciu	90	2	is	be	VBZ
cord-016523-pznw2ciu	90	3	likely	likely	JJ
cord-016523-pznw2ciu	90	4	that	that	IN
cord-016523-pznw2ciu	90	5	the	the	DT
cord-016523-pznw2ciu	90	6	low	low	JJ
cord-016523-pznw2ciu	90	7	pH	pH	NNP
cord-016523-pznw2ciu	90	8	condition	condition	NN
cord-016523-pznw2ciu	90	9	used	use	VBN
cord-016523-pznw2ciu	90	10	in	in	IN
cord-016523-pznw2ciu	90	11	the	the	DT
cord-016523-pznw2ciu	90	12	study	study	NN
cord-016523-pznw2ciu	90	13	performed	perform	VBN
cord-016523-pznw2ciu	90	14	by	by	IN
cord-016523-pznw2ciu	90	15	Scott	Scott	NNP
cord-016523-pznw2ciu	90	16	et	et	NNP
cord-016523-pznw2ciu	90	17	al	al	NNP
cord-016523-pznw2ciu	90	18	.	.	.
cord-016523-pznw2ciu	91	1	altered	alter	VBN
cord-016523-pznw2ciu	91	2	CD95	CD95	NNP
cord-016523-pznw2ciu	91	3	conformation	conformation	NN
cord-016523-pznw2ciu	91	4	and	and	CC
cord-016523-pznw2ciu	91	5	resulted	result	VBD
cord-016523-pznw2ciu	91	6	in	in	IN
cord-016523-pznw2ciu	91	7	the	the	DT
cord-016523-pznw2ciu	91	8	formation	formation	NN
cord-016523-pznw2ciu	91	9	of	of	IN
cord-016523-pznw2ciu	91	10	nonphysiological	nonphysiological	JJ
cord-016523-pznw2ciu	91	11	CD95	CD95	NNP
cord-016523-pznw2ciu	91	12	:	:	:
cord-016523-pznw2ciu	92	1	FADD	FADD	NNP
cord-016523-pznw2ciu	92	2	oligomers	oligomer	NNS
cord-016523-pznw2ciu	92	3	[	[	-LRB-
cord-016523-pznw2ciu	92	4	68	68	CD
cord-016523-pznw2ciu	92	5	]	]	-RRB-
cord-016523-pznw2ciu	92	6	.	.	.
cord-016523-pznw2ciu	93	1	Nonetheless	nonetheless	RB
cord-016523-pznw2ciu	93	2	,	,	,
cord-016523-pznw2ciu	93	3	it	-PRON-	PRP
cord-016523-pznw2ciu	93	4	can	can	MD
cord-016523-pznw2ciu	93	5	not	not	RB
cord-016523-pznw2ciu	93	6	be	be	VB
cord-016523-pznw2ciu	93	7	excluded	exclude	VBN
cord-016523-pznw2ciu	93	8	that	that	IN
cord-016523-pznw2ciu	93	9	a	a	DT
cord-016523-pznw2ciu	93	10	local	local	JJ
cord-016523-pznw2ciu	93	11	decrease	decrease	NN
cord-016523-pznw2ciu	93	12	in	in	IN
cord-016523-pznw2ciu	93	13	the	the	DT
cord-016523-pznw2ciu	93	14	intracellular	intracellular	JJ
cord-016523-pznw2ciu	93	15	pH	pH	NNP
cord-016523-pznw2ciu	93	16	affects	affect	VBZ
cord-016523-pznw2ciu	93	17	the	the	DT
cord-016523-pznw2ciu	93	18	initial	initial	JJ
cord-016523-pznw2ciu	93	19	steps	step	NNS
cord-016523-pznw2ciu	93	20	of	of	IN
cord-016523-pznw2ciu	93	21	the	the	DT
cord-016523-pznw2ciu	93	22	CD95	CD95	NNP
cord-016523-pznw2ciu	93	23	signaling	signal	VBG
cord-016523-pznw2ciu	93	24	pathway	pathway	NN
cord-016523-pznw2ciu	93	25	in	in	IN
cord-016523-pznw2ciu	93	26	vivo	vivo	NN
cord-016523-pznw2ciu	93	27	,	,	,
cord-016523-pznw2ciu	93	28	through	through	IN
cord-016523-pznw2ciu	93	29	promoting	promote	VBG
cord-016523-pznw2ciu	93	30	the	the	DT
cord-016523-pznw2ciu	93	31	opening	opening	NN
cord-016523-pznw2ciu	93	32	of	of	IN
cord-016523-pznw2ciu	93	33	the	the	DT
cord-016523-pznw2ciu	93	34	CD95-DD	cd95-dd	NN
cord-016523-pznw2ciu	93	35	and	and	CC
cord-016523-pznw2ciu	93	36	eventually	eventually	RB
cord-016523-pznw2ciu	93	37	contributing	contribute	VBG
cord-016523-pznw2ciu	93	38	to	to	IN
cord-016523-pznw2ciu	93	39	the	the	DT
cord-016523-pznw2ciu	93	40	formation	formation	NN
cord-016523-pznw2ciu	93	41	of	of	IN
cord-016523-pznw2ciu	93	42	a	a	DT
cord-016523-pznw2ciu	93	43	complex	complex	NN
cord-016523-pznw2ciu	93	44	eliciting	elicit	VBG
cord-016523-pznw2ciu	93	45	a	a	DT
cord-016523-pznw2ciu	93	46	sequence	sequence	NN
cord-016523-pznw2ciu	93	47	of	of	IN
cord-016523-pznw2ciu	93	48	events	event	NNS
cord-016523-pznw2ciu	93	49	different	different	JJ
cord-016523-pznw2ciu	93	50	from	from	IN
cord-016523-pznw2ciu	93	51	the	the	DT
cord-016523-pznw2ciu	93	52	one	one	CD
cord-016523-pznw2ciu	93	53	occurring	occur	VBG
cord-016523-pznw2ciu	93	54	at	at	IN
cord-016523-pznw2ciu	93	55	physiologic	physiologic	JJ
cord-016523-pznw2ciu	93	56	pH.	ph.	NN
cord-016523-pznw2ciu	94	1	Once	once	RB
cord-016523-pznw2ciu	94	2	docked	dock	VBN
cord-016523-pznw2ciu	94	3	on	on	IN
cord-016523-pznw2ciu	94	4	CD95-DD	cd95-dd	NN
cord-016523-pznw2ciu	94	5	,	,	,
cord-016523-pznw2ciu	94	6	FADD	FADD	NNP
cord-016523-pznw2ciu	94	7	selfassociates	selfassociate	NNS
cord-016523-pznw2ciu	94	8	[	[	-LRB-
cord-016523-pznw2ciu	94	9	71	71	CD
cord-016523-pznw2ciu	94	10	]	]	-RRB-
cord-016523-pznw2ciu	94	11	and	and	CC
cord-016523-pznw2ciu	94	12	binds	bind	VBZ
cord-016523-pznw2ciu	94	13	procaspases-8	procaspases-8	NNP
cord-016523-pznw2ciu	94	14	and	and	CC
cord-016523-pznw2ciu	94	15	procaspases-10	procaspases-10	NN
cord-016523-pznw2ciu	94	16	,	,	,
cord-016523-pznw2ciu	94	17	which	which	WDT
cord-016523-pznw2ciu	94	18	are	be	VBP
cord-016523-pznw2ciu	94	19	auto	auto	NN
cord-016523-pznw2ciu	94	20	-	-	HYPH
cord-016523-pznw2ciu	94	21	processed	process	VBN
cord-016523-pznw2ciu	94	22	and	and	CC
cord-016523-pznw2ciu	94	23	released	release	VBN
cord-016523-pznw2ciu	94	24	in	in	IN
cord-016523-pznw2ciu	94	25	the	the	DT
cord-016523-pznw2ciu	94	26	cytosol	cytosol	NN
cord-016523-pznw2ciu	94	27	as	as	IN
cord-016523-pznw2ciu	94	28	active	active	JJ
cord-016523-pznw2ciu	94	29	caspases	caspase	NNS
cord-016523-pznw2ciu	94	30	,	,	,
cord-016523-pznw2ciu	94	31	which	which	WDT
cord-016523-pznw2ciu	94	32	cleave	cleave	VBP
cord-016523-pznw2ciu	94	33	many	many	JJ
cord-016523-pznw2ciu	94	34	substrates	substrate	NNS
cord-016523-pznw2ciu	94	35	leading	lead	VBG
cord-016523-pznw2ciu	94	36	to	to	IN
cord-016523-pznw2ciu	94	37	the	the	DT
cord-016523-pznw2ciu	94	38	execution	execution	NN
cord-016523-pznw2ciu	94	39	of	of	IN
cord-016523-pznw2ciu	94	40	the	the	DT
cord-016523-pznw2ciu	94	41	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	94	42	program	program	NN
cord-016523-pznw2ciu	94	43	and	and	CC
cord-016523-pznw2ciu	94	44	cell	cell	NN
cord-016523-pznw2ciu	94	45	death	death	NN
cord-016523-pznw2ciu	94	46	.	.	.
cord-016523-pznw2ciu	95	1	The	the	DT
cord-016523-pznw2ciu	95	2	complex	complex	JJ
cord-016523-pznw2ciu	95	3	CD95	CD95	NNP
cord-016523-pznw2ciu	95	4	/	/	SYM
cord-016523-pznw2ciu	95	5	FADD	FADD	NNP
cord-016523-pznw2ciu	95	6	/	/	SYM
cord-016523-pznw2ciu	95	7	caspase-8/	caspase-8/	NNP
cord-016523-pznw2ciu	95	8	caspase-10	caspase-10	NN
cord-016523-pznw2ciu	95	9	is	be	VBZ
cord-016523-pznw2ciu	95	10	called	call	VBN
cord-016523-pznw2ciu	95	11	DISC	DISC	NNP
cord-016523-pznw2ciu	96	1	(	(	-LRB-
cord-016523-pznw2ciu	96	2	Fig	Fig	NNP
cord-016523-pznw2ciu	96	3	.	.	.
cord-016523-pznw2ciu	97	1	9	9	LS
cord-016523-pznw2ciu	97	2	.2	.2	CD
cord-016523-pznw2ciu	97	3	)	)	-RRB-
cord-016523-pznw2ciu	97	4	[	[	-LRB-
cord-016523-pznw2ciu	97	5	10	10	CD
cord-016523-pznw2ciu	97	6	]	]	-RRB-
cord-016523-pznw2ciu	97	7	.	.	.
cord-016523-pznw2ciu	98	1	Due	due	IN
cord-016523-pznw2ciu	98	2	to	to	IN
cord-016523-pznw2ciu	98	3	the	the	DT
cord-016523-pznw2ciu	98	4	importance	importance	NN
cord-016523-pznw2ciu	98	5	of	of	IN
cord-016523-pznw2ciu	98	6	DISC	disc	NN
cord-016523-pznw2ciu	98	7	formation	formation	NN
cord-016523-pznw2ciu	98	8	in	in	IN
cord-016523-pznw2ciu	98	9	the	the	DT
cord-016523-pznw2ciu	98	10	fate	fate	NN
cord-016523-pznw2ciu	98	11	of	of	IN
cord-016523-pznw2ciu	98	12	cells	cell	NNS
cord-016523-pznw2ciu	98	13	,	,	,
cord-016523-pznw2ciu	98	14	it	-PRON-	PRP
cord-016523-pznw2ciu	98	15	is	be	VBZ
cord-016523-pznw2ciu	98	16	not	not	RB
cord-016523-pznw2ciu	98	17	surprising	surprising	JJ
cord-016523-pznw2ciu	98	18	that	that	IN
cord-016523-pznw2ciu	98	19	numerous	numerous	JJ
cord-016523-pznw2ciu	98	20	cellular	cellular	JJ
cord-016523-pznw2ciu	98	21	and	and	CC
cord-016523-pznw2ciu	98	22	viral	viral	JJ
cord-016523-pznw2ciu	98	23	proteins	protein	NNS
cord-016523-pznw2ciu	98	24	were	be	VBD
cord-016523-pznw2ciu	98	25	reported	report	VBN
cord-016523-pznw2ciu	98	26	to	to	TO
cord-016523-pznw2ciu	98	27	hamper	hamper	VB
cord-016523-pznw2ciu	98	28	the	the	DT
cord-016523-pznw2ciu	98	29	formation	formation	NN
cord-016523-pznw2ciu	98	30	of	of	IN
cord-016523-pznw2ciu	98	31	this	this	DT
cord-016523-pznw2ciu	98	32	structure	structure	NN
cord-016523-pznw2ciu	98	33	,	,	,
cord-016523-pznw2ciu	98	34	such	such	JJ
cord-016523-pznw2ciu	98	35	as	as	IN
cord-016523-pznw2ciu	98	36	FLIP	FLIP	NNP
cord-016523-pznw2ciu	98	37	[	[	-LRB-
cord-016523-pznw2ciu	98	38	72	72	CD
cord-016523-pznw2ciu	98	39	,	,	,
cord-016523-pznw2ciu	98	40	73	73	CD
cord-016523-pznw2ciu	98	41	]	]	-RRB-
cord-016523-pznw2ciu	98	42	and	and	CC
cord-016523-pznw2ciu	98	43	PED	PED	NNP
cord-016523-pznw2ciu	98	44	/	/	SYM
cord-016523-pznw2ciu	98	45	PEA-15	PEA-15	NNP
cord-016523-pznw2ciu	98	46	[	[	-LRB-
cord-016523-pznw2ciu	98	47	74	74	CD
cord-016523-pznw2ciu	98	48	]	]	-RRB-
cord-016523-pznw2ciu	98	49	,	,	,
cord-016523-pznw2ciu	98	50	which	which	WDT
cord-016523-pznw2ciu	98	51	interfere	interfere	VBP
cord-016523-pznw2ciu	98	52	with	with	IN
cord-016523-pznw2ciu	98	53	the	the	DT
cord-016523-pznw2ciu	98	54	recruitment	recruitment	NN
cord-016523-pznw2ciu	98	55	of	of	IN
cord-016523-pznw2ciu	98	56	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	98	57	/	/	SYM
cord-016523-pznw2ciu	98	58	caspase-10	caspase-10	NN
cord-016523-pznw2ciu	99	1	(	(	-LRB-
cord-016523-pznw2ciu	99	2	Fig	Fig	NNP
cord-016523-pznw2ciu	99	3	.	.	.
cord-016523-pznw2ciu	99	4	9	9	CD
cord-016523-pznw2ciu	99	5	.2	.2	CD
cord-016523-pznw2ciu	99	6	)	)	-RRB-
cord-016523-pznw2ciu	99	7	.	.	.
cord-016523-pznw2ciu	100	1	Fig	Fig	NNP
cord-016523-pznw2ciu	100	2	.	.	.
cord-016523-pznw2ciu	101	1	9	9	LS
cord-016523-pznw2ciu	101	2	.2	.2	.
cord-016523-pznw2ciu	102	1	Type	Type	NNP
cord-016523-pznw2ciu	102	2	I	I	NNP
cord-016523-pznw2ciu	102	3	/	/	SYM
cord-016523-pznw2ciu	102	4	II	ii	CD
cord-016523-pznw2ciu	102	5	cells	cell	NNS
cord-016523-pznw2ciu	102	6	.	.	.
cord-016523-pznw2ciu	103	1	Binding	bind	VBG
cord-016523-pznw2ciu	103	2	of	of	IN
cord-016523-pznw2ciu	103	3	transmembrane	transmembrane	NN
cord-016523-pznw2ciu	103	4	CD95L	CD95L	NNS
cord-016523-pznw2ciu	103	5	to	to	IN
cord-016523-pznw2ciu	103	6	CD95	CD95	NNP
cord-016523-pznw2ciu	103	7	leads	lead	VBZ
cord-016523-pznw2ciu	103	8	to	to	IN
cord-016523-pznw2ciu	103	9	DISC	disc	VB
cord-016523-pznw2ciu	103	10	formation	formation	NN
cord-016523-pznw2ciu	103	11	.	.	.
cord-016523-pznw2ciu	104	1	DISC	DISC	NNP
cord-016523-pznw2ciu	104	2	consists	consist	VBZ
cord-016523-pznw2ciu	104	3	of	of	IN
cord-016523-pznw2ciu	104	4	FADD	FADD	NNP
cord-016523-pznw2ciu	104	5	and	and	CC
cord-016523-pznw2ciu	104	6	procaspase-8	procaspase-8	NNP
cord-016523-pznw2ciu	104	7	.	.	.
cord-016523-pznw2ciu	105	1	C	C	NNP
cord-016523-pznw2ciu	105	2	-	-	HYPH
cord-016523-pznw2ciu	105	3	FLIP	FLIP	NNP
cord-016523-pznw2ciu	105	4	and	and	CC
cord-016523-pznw2ciu	105	5	PEA-15	PEA-15	NNP
cord-016523-pznw2ciu	105	6	bind	bind	VBP
cord-016523-pznw2ciu	105	7	to	to	IN
cord-016523-pznw2ciu	105	8	FADD	FADD	NNP
cord-016523-pznw2ciu	105	9	and	and	CC
cord-016523-pznw2ciu	105	10	prevent	prevent	VB
cord-016523-pznw2ciu	105	11	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	105	12	recruitment	recruitment	NN
cord-016523-pznw2ciu	105	13	.	.	.
cord-016523-pznw2ciu	106	1	At	at	IN
cord-016523-pznw2ciu	106	2	the	the	DT
cord-016523-pznw2ciu	106	3	DISC	disc	NN
cord-016523-pznw2ciu	106	4	level	level	NN
cord-016523-pznw2ciu	106	5	,	,	,
cord-016523-pznw2ciu	106	6	aggregation	aggregation	NN
cord-016523-pznw2ciu	106	7	of	of	IN
cord-016523-pznw2ciu	106	8	procaspase-8	procaspase-8	NNP
cord-016523-pznw2ciu	106	9	promotes	promote	VBZ
cord-016523-pznw2ciu	106	10	its	-PRON-	PRP$
cord-016523-pznw2ciu	106	11	autocleavage	autocleavage	NN
cord-016523-pznw2ciu	106	12	and	and	CC
cord-016523-pznw2ciu	106	13	activation	activation	NN
cord-016523-pznw2ciu	106	14	.	.	.
cord-016523-pznw2ciu	107	1	Cleaved	Cleaved	NNP
cord-016523-pznw2ciu	107	2	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	107	3	is	be	VBZ
cord-016523-pznw2ciu	107	4	then	then	RB
cord-016523-pznw2ciu	107	5	released	release	VBN
cord-016523-pznw2ciu	107	6	in	in	IN
cord-016523-pznw2ciu	107	7	the	the	DT
cord-016523-pznw2ciu	107	8	cytosol	cytosol	NN
cord-016523-pznw2ciu	107	9	where	where	WRB
cord-016523-pznw2ciu	107	10	it	-PRON-	PRP
cord-016523-pznw2ciu	107	11	promotes	promote	VBZ
cord-016523-pznw2ciu	107	12	the	the	DT
cord-016523-pznw2ciu	107	13	cascade	cascade	NN
cord-016523-pznw2ciu	107	14	of	of	IN
cord-016523-pznw2ciu	107	15	caspase	caspase	NN
cord-016523-pznw2ciu	107	16	activation	activation	NN
cord-016523-pznw2ciu	107	17	leading	lead	VBG
cord-016523-pznw2ciu	107	18	to	to	IN
cord-016523-pznw2ciu	107	19	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	107	20	.	.	.
cord-016523-pznw2ciu	108	1	Type	type	NN
cord-016523-pznw2ciu	108	2	I	-PRON-	PRP
cord-016523-pznw2ciu	108	3	cells	cell	NNS
cord-016523-pznw2ciu	108	4	are	be	VBP
cord-016523-pznw2ciu	108	5	characterized	characterize	VBN
cord-016523-pznw2ciu	108	6	by	by	IN
cord-016523-pznw2ciu	108	7	an	an	DT
cord-016523-pznw2ciu	108	8	effi	effi	NNP
cord-016523-pznw2ciu	108	9	cient	cient	NNP
cord-016523-pznw2ciu	108	10	DISC	DISC	NNP
cord-016523-pznw2ciu	108	11	formation	formation	NN
cord-016523-pznw2ciu	108	12	,	,	,
cord-016523-pznw2ciu	108	13	which	which	WDT
cord-016523-pznw2ciu	108	14	releases	release	VBZ
cord-016523-pznw2ciu	108	15	suffi	suffi	NNP
cord-016523-pznw2ciu	108	16	cient	cient	NNP
cord-016523-pznw2ciu	108	17	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	108	18	to	to	TO
cord-016523-pznw2ciu	108	19	directly	directly	RB
cord-016523-pznw2ciu	108	20	activate	activate	VB
cord-016523-pznw2ciu	108	21	caspase-3	caspase-3	NNP
cord-016523-pznw2ciu	108	22	.	.	.
cord-016523-pznw2ciu	109	1	By	by	IN
cord-016523-pznw2ciu	109	2	contrast	contrast	NN
cord-016523-pznw2ciu	109	3	,	,	,
cord-016523-pznw2ciu	109	4	type	type	NN
cord-016523-pznw2ciu	109	5	II	ii	CD
cord-016523-pznw2ciu	109	6	cells	cell	NNS
cord-016523-pznw2ciu	109	7	present	present	VBP
cord-016523-pznw2ciu	109	8	a	a	DT
cord-016523-pznw2ciu	109	9	weak	weak	JJ
cord-016523-pznw2ciu	109	10	DISC	disc	NN
cord-016523-pznw2ciu	109	11	formation	formation	NN
cord-016523-pznw2ciu	109	12	,	,	,
cord-016523-pznw2ciu	109	13	and	and	CC
cord-016523-pznw2ciu	109	14	the	the	DT
cord-016523-pznw2ciu	109	15	low	low	JJ
cord-016523-pznw2ciu	109	16	amount	amount	NN
cord-016523-pznw2ciu	109	17	of	of	IN
cord-016523-pznw2ciu	109	18	released	release	VBN
cord-016523-pznw2ciu	109	19	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	109	20	activates	activate	VBZ
cord-016523-pznw2ciu	109	21	the	the	DT
cord-016523-pznw2ciu	109	22	mitochondrion	mitochondrion	NN
cord-016523-pznw2ciu	109	23	-	-	HYPH
cord-016523-pznw2ciu	109	24	dependent	dependent	JJ
cord-016523-pznw2ciu	109	25	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	109	26	pathway	pathway	NN
cord-016523-pznw2ciu	109	27	to	to	TO
cord-016523-pznw2ciu	109	28	amplify	amplify	VB
cord-016523-pznw2ciu	109	29	death	death	NN
cord-016523-pznw2ciu	109	30	signal	signal	NN
cord-016523-pznw2ciu	109	31	Following	follow	VBG
cord-016523-pznw2ciu	109	32	the	the	DT
cord-016523-pznw2ciu	109	33	discovery	discovery	NN
cord-016523-pznw2ciu	109	34	of	of	IN
cord-016523-pznw2ciu	109	35	CD95	CD95	NNP
cord-016523-pznw2ciu	109	36	and	and	CC
cord-016523-pznw2ciu	109	37	the	the	DT
cord-016523-pznw2ciu	109	38	fi	fi	NN
cord-016523-pznw2ciu	109	39	rst	rst	NN
cord-016523-pznw2ciu	109	40	steps	step	NNS
cord-016523-pznw2ciu	109	41	of	of	IN
cord-016523-pznw2ciu	109	42	its	-PRON-	PRP$
cord-016523-pznw2ciu	109	43	signaling	signal	VBG
cord-016523-pznw2ciu	109	44	pathway	pathway	NN
cord-016523-pznw2ciu	110	1	,	,	,
cord-016523-pznw2ciu	110	2	Peter	Peter	NNP
cord-016523-pznw2ciu	110	3	and	and	CC
cord-016523-pznw2ciu	110	4	colleagues	colleague	NNS
cord-016523-pznw2ciu	110	5	described	describe	VBD
cord-016523-pznw2ciu	110	6	that	that	IN
cord-016523-pznw2ciu	110	7	cells	cell	NNS
cord-016523-pznw2ciu	110	8	can	can	MD
cord-016523-pznw2ciu	110	9	be	be	VB
cord-016523-pznw2ciu	110	10	divided	divide	VBN
cord-016523-pznw2ciu	110	11	in	in	IN
cord-016523-pznw2ciu	110	12	two	two	CD
cord-016523-pznw2ciu	110	13	groups	group	NNS
cord-016523-pznw2ciu	110	14	with	with	IN
cord-016523-pznw2ciu	110	15	regard	regard	NN
cord-016523-pznw2ciu	110	16	to	to	IN
cord-016523-pznw2ciu	110	17	the	the	DT
cord-016523-pznw2ciu	110	18	kinetics	kinetic	NNS
cord-016523-pznw2ciu	110	19	through	through	IN
cord-016523-pznw2ciu	110	20	which	which	WDT
cord-016523-pznw2ciu	110	21	they	-PRON-	PRP
cord-016523-pznw2ciu	110	22	respond	respond	VBP
cord-016523-pznw2ciu	110	23	to	to	IN
cord-016523-pznw2ciu	110	24	CD95-mediated	cd95-mediated	CD
cord-016523-pznw2ciu	110	25	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	110	26	signals	signal	NNS
cord-016523-pznw2ciu	110	27	,	,	,
cord-016523-pznw2ciu	110	28	the	the	DT
cord-016523-pznw2ciu	110	29	magnitude	magnitude	NN
cord-016523-pznw2ciu	110	30	of	of	IN
cord-016523-pznw2ciu	110	31	DISC	disc	NN
cord-016523-pznw2ciu	110	32	formation	formation	NN
cord-016523-pznw2ciu	110	33	and	and	CC
cord-016523-pznw2ciu	110	34	the	the	DT
cord-016523-pznw2ciu	110	35	role	role	NN
cord-016523-pznw2ciu	110	36	played	play	VBN
cord-016523-pznw2ciu	110	37	by	by	IN
cord-016523-pznw2ciu	110	38	the	the	DT
cord-016523-pznw2ciu	110	39	mitochondrion	mitochondrion	NN
cord-016523-pznw2ciu	110	40	in	in	IN
cord-016523-pznw2ciu	110	41	this	this	DT
cord-016523-pznw2ciu	110	42	pathway	pathway	NN
cord-016523-pznw2ciu	110	43	[	[	-LRB-
cord-016523-pznw2ciu	110	44	75	75	CD
cord-016523-pznw2ciu	110	45	]	]	-RRB-
cord-016523-pznw2ciu	110	46	.	.	.
cord-016523-pznw2ciu	111	1	DISC	disc	NN
cord-016523-pznw2ciu	111	2	formation	formation	NN
cord-016523-pznw2ciu	111	3	occurs	occur	VBZ
cord-016523-pznw2ciu	111	4	rapidly	rapidly	RB
cord-016523-pznw2ciu	111	5	and	and	CC
cord-016523-pznw2ciu	111	6	effi	effi	NNP
cord-016523-pznw2ciu	111	7	ciently	ciently	NNP
cord-016523-pznw2ciu	111	8	in	in	IN
cord-016523-pznw2ciu	111	9	type	type	NN
cord-016523-pznw2ciu	112	1	I	-PRON-	PRP
cord-016523-pznw2ciu	112	2	cells	cells	VBP
cord-016523-pznw2ciu	112	3	releasing	release	VBG
cord-016523-pznw2ciu	112	4	a	a	DT
cord-016523-pznw2ciu	112	5	large	large	JJ
cord-016523-pznw2ciu	112	6	amount	amount	NN
cord-016523-pznw2ciu	112	7	of	of	IN
cord-016523-pznw2ciu	112	8	activated	activate	VBN
cord-016523-pznw2ciu	112	9	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	112	10	in	in	IN
cord-016523-pznw2ciu	112	11	the	the	DT
cord-016523-pznw2ciu	112	12	cytosol	cytosol	NN
cord-016523-pznw2ciu	112	13	,	,	,
cord-016523-pznw2ciu	112	14	while	while	IN
cord-016523-pznw2ciu	112	15	type	type	NN
cord-016523-pznw2ciu	112	16	II	II	NNP
cord-016523-pznw2ciu	112	17	cells	cell	NNS
cord-016523-pznw2ciu	112	18	have	have	VBP
cord-016523-pznw2ciu	112	19	diffi	diffi	NNP
cord-016523-pznw2ciu	112	20	culty	culty	NNP
cord-016523-pznw2ciu	112	21	forming	form	VBG
cord-016523-pznw2ciu	112	22	this	this	DT
cord-016523-pznw2ciu	112	23	complex	complex	NN
cord-016523-pznw2ciu	112	24	,	,	,
cord-016523-pznw2ciu	112	25	and	and	CC
cord-016523-pznw2ciu	112	26	the	the	DT
cord-016523-pznw2ciu	112	27	amount	amount	NN
cord-016523-pznw2ciu	112	28	of	of	IN
cord-016523-pznw2ciu	112	29	active	active	JJ
cord-016523-pznw2ciu	112	30	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	112	31	is	be	VBZ
cord-016523-pznw2ciu	112	32	insuffi	insuffi	NNP
cord-016523-pznw2ciu	112	33	cient	cient	NN
cord-016523-pznw2ciu	112	34	to	to	TO
cord-016523-pznw2ciu	112	35	directly	directly	RB
cord-016523-pznw2ciu	112	36	activate	activate	VB
cord-016523-pznw2ciu	112	37	the	the	DT
cord-016523-pznw2ciu	112	38	effector	effector	NN
cord-016523-pznw2ciu	112	39	caspase-3	caspase-3	NNP
cord-016523-pznw2ciu	112	40	and	and	CC
cord-016523-pznw2ciu	112	41	caspase-7	caspase-7	NNP
cord-016523-pznw2ciu	112	42	[	[	-LRB-
cord-016523-pznw2ciu	112	43	75	75	CD
cord-016523-pznw2ciu	112	44	]	]	-RRB-
cord-016523-pznw2ciu	112	45	.	.	.
cord-016523-pznw2ciu	113	1	Nonetheless	nonetheless	RB
cord-016523-pznw2ciu	113	2	,	,	,
cord-016523-pznw2ciu	113	3	type	type	NN
cord-016523-pznw2ciu	113	4	II	ii	CD
cord-016523-pznw2ciu	113	5	cells	cell	NNS
cord-016523-pznw2ciu	113	6	experience	experience	VBP
cord-016523-pznw2ciu	113	7	cell	cell	NN
cord-016523-pznw2ciu	113	8	death	death	NN
cord-016523-pznw2ciu	113	9	upon	upon	IN
cord-016523-pznw2ciu	113	10	CD95	CD95	NNP
cord-016523-pznw2ciu	113	11	engagement	engagement	NN
cord-016523-pznw2ciu	113	12	and	and	CC
cord-016523-pznw2ciu	113	13	are	be	VBP
cord-016523-pznw2ciu	113	14	even	even	RB
cord-016523-pznw2ciu	113	15	more	more	RBR
cord-016523-pznw2ciu	113	16	sensitive	sensitive	JJ
cord-016523-pznw2ciu	113	17	to	to	IN
cord-016523-pznw2ciu	113	18	the	the	DT
cord-016523-pznw2ciu	113	19	CD95mediated	cd95mediated	JJ
cord-016523-pznw2ciu	113	20	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	113	21	signal	signal	NN
cord-016523-pznw2ciu	113	22	compared	compare	VBN
cord-016523-pznw2ciu	113	23	to	to	IN
cord-016523-pznw2ciu	113	24	type	type	NN
cord-016523-pznw2ciu	113	25	I	-PRON-	PRP
cord-016523-pznw2ciu	113	26	cells	cells	VBP
cord-016523-pznw2ciu	113	27	[	[	-LRB-
cord-016523-pznw2ciu	113	28	75	75	CD
cord-016523-pznw2ciu	113	29	-77	-77	CD
cord-016523-pznw2ciu	113	30	]	]	-RRB-
cord-016523-pznw2ciu	113	31	.	.	.
cord-016523-pznw2ciu	114	1	This	this	DT
cord-016523-pznw2ciu	114	2	discrepancy	discrepancy	NN
cord-016523-pznw2ciu	114	3	can	can	MD
cord-016523-pznw2ciu	114	4	be	be	VB
cord-016523-pznw2ciu	114	5	partly	partly	RB
cord-016523-pznw2ciu	114	6	explained	explain	VBN
cord-016523-pznw2ciu	114	7	by	by	IN
cord-016523-pznw2ciu	114	8	the	the	DT
cord-016523-pznw2ciu	114	9	fact	fact	NN
cord-016523-pznw2ciu	114	10	that	that	IN
cord-016523-pznw2ciu	114	11	the	the	DT
cord-016523-pznw2ciu	114	12	low	low	JJ
cord-016523-pznw2ciu	114	13	amount	amount	NN
cord-016523-pznw2ciu	114	14	of	of	IN
cord-016523-pznw2ciu	114	15	activated	activate	VBN
cord-016523-pznw2ciu	114	16	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	114	17	in	in	IN
cord-016523-pznw2ciu	114	18	type	type	NN
cord-016523-pznw2ciu	114	19	II	ii	CD
cord-016523-pznw2ciu	114	20	cells	cell	NNS
cord-016523-pznw2ciu	114	21	is	be	VBZ
cord-016523-pznw2ciu	114	22	suffi	suffi	NNP
cord-016523-pznw2ciu	114	23	cient	cient	NNP
cord-016523-pznw2ciu	114	24	to	to	TO
cord-016523-pznw2ciu	114	25	cleave	cleave	VB
cord-016523-pznw2ciu	114	26	BID	BID	NNP
cord-016523-pznw2ciu	114	27	,	,	,
cord-016523-pznw2ciu	114	28	a	a	DT
cord-016523-pznw2ciu	114	29	BH3-only	bh3-only	NN
cord-016523-pznw2ciu	114	30	protein	protein	NN
cord-016523-pznw2ciu	114	31	,	,	,
cord-016523-pznw2ciu	114	32	which	which	WDT
cord-016523-pznw2ciu	114	33	constitutes	constitute	VBZ
cord-016523-pznw2ciu	114	34	the	the	DT
cord-016523-pznw2ciu	114	35	molecular	molecular	JJ
cord-016523-pznw2ciu	114	36	link	link	NN
cord-016523-pznw2ciu	114	37	between	between	IN
cord-016523-pznw2ciu	114	38	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	114	39	activation	activation	NN
cord-016523-pznw2ciu	114	40	and	and	CC
cord-016523-pznw2ciu	114	41	the	the	DT
cord-016523-pznw2ciu	114	42	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	114	43	activity	activity	NN
cord-016523-pznw2ciu	114	44	of	of	IN
cord-016523-pznw2ciu	114	45	mitochondria	mitochondrion	NNS
cord-016523-pznw2ciu	114	46	.	.	.
cord-016523-pznw2ciu	115	1	Indeed	indeed	RB
cord-016523-pznw2ciu	115	2	,	,	,
cord-016523-pznw2ciu	115	3	after	after	IN
cord-016523-pznw2ciu	115	4	cleavage	cleavage	NN
cord-016523-pznw2ciu	115	5	by	by	IN
cord-016523-pznw2ciu	115	6	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	115	7	,	,	,
cord-016523-pznw2ciu	115	8	truncated	truncated	JJ
cord-016523-pznw2ciu	115	9	BID	bid	NN
cord-016523-pznw2ciu	115	10	(	(	-LRB-
cord-016523-pznw2ciu	115	11	tBID	tBID	NNS
cord-016523-pznw2ciu	115	12	)	)	-RRB-
cord-016523-pznw2ciu	115	13	translocates	translocate	NNS
cord-016523-pznw2ciu	115	14	to	to	IN
cord-016523-pznw2ciu	115	15	mitochondria	mitochondrion	NNS
cord-016523-pznw2ciu	115	16	,	,	,
cord-016523-pznw2ciu	115	17	where	where	WRB
cord-016523-pznw2ciu	115	18	it	-PRON-	PRP
cord-016523-pznw2ciu	115	19	triggers	trigger	VBZ
cord-016523-pznw2ciu	115	20	the	the	DT
cord-016523-pznw2ciu	115	21	release	release	NN
cord-016523-pznw2ciu	115	22	of	of	IN
cord-016523-pznw2ciu	115	23	proapoptotic	proapoptotic	JJ
cord-016523-pznw2ciu	115	24	factors	factor	NNS
cord-016523-pznw2ciu	115	25	(	(	-LRB-
cord-016523-pznw2ciu	115	26	Fig	Fig	NNP
cord-016523-pznw2ciu	115	27	.	.	.
cord-016523-pznw2ciu	115	28	9	9	CD
cord-016523-pznw2ciu	115	29	.2	.2	CD
cord-016523-pznw2ciu	115	30	)	)	-RRB-
cord-016523-pznw2ciu	116	1	[	[	-LRB-
cord-016523-pznw2ciu	116	2	78	78	CD
cord-016523-pznw2ciu	116	3	,	,	,
cord-016523-pznw2ciu	116	4	79	79	CD
cord-016523-pznw2ciu	116	5	]	]	-RRB-
cord-016523-pznw2ciu	116	6	.	.	.
cord-016523-pznw2ciu	117	1	Although	although	IN
cord-016523-pznw2ciu	117	2	CD95	CD95	NNP
cord-016523-pznw2ciu	117	3	stimulation	stimulation	NN
cord-016523-pznw2ciu	117	4	activates	activate	VBZ
cord-016523-pznw2ciu	117	5	the	the	DT
cord-016523-pznw2ciu	117	6	mitochondrion	mitochondrion	NN
cord-016523-pznw2ciu	117	7	-	-	HYPH
cord-016523-pznw2ciu	117	8	dependent	dependent	JJ
cord-016523-pznw2ciu	117	9	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	117	10	signal	signal	NN
cord-016523-pznw2ciu	117	11	in	in	IN
cord-016523-pznw2ciu	117	12	type	type	NN
cord-016523-pznw2ciu	117	13	I	-PRON-	PRP
cord-016523-pznw2ciu	117	14	and	and	CC
cord-016523-pznw2ciu	117	15	type	type	NN
cord-016523-pznw2ciu	117	16	II	ii	CD
cord-016523-pznw2ciu	117	17	cells	cell	NNS
cord-016523-pznw2ciu	117	18	,	,	,
cord-016523-pznw2ciu	117	19	it	-PRON-	PRP
cord-016523-pznw2ciu	117	20	seems	seem	VBZ
cord-016523-pznw2ciu	117	21	that	that	IN
cord-016523-pznw2ciu	117	22	only	only	JJ
cord-016523-pznw2ciu	117	23	type	type	NN
cord-016523-pznw2ciu	117	24	II	ii	CD
cord-016523-pznw2ciu	117	25	cells	cell	NNS
cord-016523-pznw2ciu	117	26	are	be	VBP
cord-016523-pznw2ciu	117	27	addicted	addicted	JJ
cord-016523-pznw2ciu	117	28	to	to	IN
cord-016523-pznw2ciu	117	29	this	this	DT
cord-016523-pznw2ciu	117	30	signal	signal	NN
cord-016523-pznw2ciu	117	31	as	as	IN
cord-016523-pznw2ciu	117	32	they	-PRON-	PRP
cord-016523-pznw2ciu	117	33	display	display	VBP
cord-016523-pznw2ciu	117	34	a	a	DT
cord-016523-pznw2ciu	117	35	higher	high	JJR
cord-016523-pznw2ciu	117	36	amount	amount	NN
cord-016523-pznw2ciu	117	37	of	of	IN
cord-016523-pznw2ciu	117	38	the	the	DT
cord-016523-pznw2ciu	117	39	caspase-3	caspase-3	NNP
cord-016523-pznw2ciu	117	40	inhibitor	inhibitor	NN
cord-016523-pznw2ciu	117	41	XIAP	xiap	NN
cord-016523-pznw2ciu	117	42	compared	compare	VBN
cord-016523-pznw2ciu	117	43	to	to	IN
cord-016523-pznw2ciu	117	44	type	type	NN
cord-016523-pznw2ciu	117	45	I	-PRON-	PRP
cord-016523-pznw2ciu	117	46	cells	cells	VBP
cord-016523-pznw2ciu	117	47	[	[	-LRB-
cord-016523-pznw2ciu	117	48	80	80	CD
cord-016523-pznw2ciu	117	49	]	]	-RRB-
cord-016523-pznw2ciu	117	50	.	.	.
cord-016523-pznw2ciu	118	1	Among	among	IN
cord-016523-pznw2ciu	118	2	the	the	DT
cord-016523-pznw2ciu	118	3	inhibitor	inhibitor	NN
cord-016523-pznw2ciu	118	4	of	of	IN
cord-016523-pznw2ciu	118	5	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	118	6	protein	protein	NN
cord-016523-pznw2ciu	118	7	(	(	-LRB-
cord-016523-pznw2ciu	118	8	IAP	IAP	NNP
cord-016523-pznw2ciu	118	9	)	)	-RRB-
cord-016523-pznw2ciu	118	10	family	family	NN
cord-016523-pznw2ciu	118	11	,	,	,
cord-016523-pznw2ciu	118	12	XIAP	XIAP	NNP
cord-016523-pznw2ciu	118	13	,	,	,
cord-016523-pznw2ciu	118	14	c	c	NNP
cord-016523-pznw2ciu	118	15	-	-	:
cord-016523-pznw2ciu	118	16	IAP1	IAP1	NNP
cord-016523-pznw2ciu	118	17	,	,	,
cord-016523-pznw2ciu	118	18	and	and	CC
cord-016523-pznw2ciu	118	19	c	c	LS
cord-016523-pznw2ciu	118	20	-	-	:
cord-016523-pznw2ciu	118	21	IAP2	IAP2	NNP
cord-016523-pznw2ciu	118	22	inhibit	inhibit	VBP
cord-016523-pznw2ciu	118	23	caspase-3	caspase-3	NNP
cord-016523-pznw2ciu	118	24	,	,	,
cord-016523-pznw2ciu	118	25	caspase-7	caspase-7	NNP
cord-016523-pznw2ciu	118	26	[	[	-LRB-
cord-016523-pznw2ciu	118	27	81	81	CD
cord-016523-pznw2ciu	118	28	,	,	,
cord-016523-pznw2ciu	118	29	82	82	CD
cord-016523-pznw2ciu	118	30	]	]	-RRB-
cord-016523-pznw2ciu	118	31	,	,	,
cord-016523-pznw2ciu	118	32	and	and	CC
cord-016523-pznw2ciu	118	33	procaspase-9	procaspase-9	NNP
cord-016523-pznw2ciu	118	34	[	[	-LRB-
cord-016523-pznw2ciu	118	35	83	83	CD
cord-016523-pznw2ciu	118	36	]	]	-RRB-
cord-016523-pznw2ciu	118	37	activity	activity	NN
cord-016523-pznw2ciu	118	38	by	by	IN
cord-016523-pznw2ciu	118	39	direct	direct	JJ
cord-016523-pznw2ciu	118	40	binding	binding	NN
cord-016523-pznw2ciu	118	41	,	,	,
cord-016523-pznw2ciu	118	42	thereby	thereby	RB
cord-016523-pznw2ciu	118	43	preventing	prevent	VBG
cord-016523-pznw2ciu	118	44	access	access	NN
cord-016523-pznw2ciu	118	45	to	to	IN
cord-016523-pznw2ciu	118	46	substrates	substrate	NNS
cord-016523-pznw2ciu	118	47	.	.	.
cord-016523-pznw2ciu	119	1	Furthermore	furthermore	RB
cord-016523-pznw2ciu	119	2	,	,	,
cord-016523-pznw2ciu	119	3	XIAP	XIAP	NNP
cord-016523-pznw2ciu	119	4	can	can	MD
cord-016523-pznw2ciu	119	5	function	function	VB
cord-016523-pznw2ciu	119	6	as	as	IN
cord-016523-pznw2ciu	119	7	an	an	DT
cord-016523-pznw2ciu	119	8	E3	e3	NN
cord-016523-pznw2ciu	119	9	ligase	ligase	NN
cord-016523-pznw2ciu	119	10	whose	whose	WP$
cord-016523-pznw2ciu	119	11	activity	activity	NN
cord-016523-pznw2ciu	119	12	is	be	VBZ
cord-016523-pznw2ciu	119	13	involved	involve	VBN
cord-016523-pznw2ciu	119	14	in	in	IN
cord-016523-pznw2ciu	119	15	the	the	DT
cord-016523-pznw2ciu	119	16	ubiquitination	ubiquitination	NN
cord-016523-pznw2ciu	119	17	of	of	IN
cord-016523-pznw2ciu	119	18	active	active	JJ
cord-016523-pznw2ciu	119	19	caspase-3	caspase-3	NNP
cord-016523-pznw2ciu	119	20	and	and	CC
cord-016523-pznw2ciu	119	21	its	-PRON-	PRP$
cord-016523-pznw2ciu	119	22	subsequent	subsequent	JJ
cord-016523-pznw2ciu	119	23	degradation	degradation	NN
cord-016523-pznw2ciu	119	24	through	through	IN
cord-016523-pznw2ciu	119	25	the	the	DT
cord-016523-pznw2ciu	119	26	proteasome	proteasome	NN
cord-016523-pznw2ciu	119	27	[	[	-LRB-
cord-016523-pznw2ciu	119	28	84	84	CD
cord-016523-pznw2ciu	119	29	]	]	-RRB-
cord-016523-pznw2ciu	119	30	.	.	.
cord-016523-pznw2ciu	120	1	To	to	TO
cord-016523-pznw2ciu	120	2	detach	detach	VB
cord-016523-pznw2ciu	120	3	XIAP	xiap	NN
cord-016523-pznw2ciu	120	4	from	from	IN
cord-016523-pznw2ciu	120	5	caspase-3	caspase-3	NNP
cord-016523-pznw2ciu	120	6	and	and	CC
cord-016523-pznw2ciu	120	7	restore	restore	VB
cord-016523-pznw2ciu	120	8	the	the	DT
cord-016523-pznw2ciu	120	9	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	120	10	signal	signal	NN
cord-016523-pznw2ciu	120	11	,	,	,
cord-016523-pznw2ciu	120	12	cells	cell	NNS
cord-016523-pznw2ciu	120	13	require	require	VBP
cord-016523-pznw2ciu	120	14	the	the	DT
cord-016523-pznw2ciu	120	15	release	release	NN
cord-016523-pznw2ciu	120	16	of	of	IN
cord-016523-pznw2ciu	120	17	SMAC	SMAC	NNP
cord-016523-pznw2ciu	120	18	/	/	SYM
cord-016523-pznw2ciu	120	19	DIABLO	DIABLO	NNP
cord-016523-pznw2ciu	120	20	(	(	-LRB-
cord-016523-pznw2ciu	120	21	second	second	JJ
cord-016523-pznw2ciu	120	22	mitochondria	mitochondria	NN
cord-016523-pznw2ciu	120	23	-	-	HYPH
cord-016523-pznw2ciu	120	24	derived	derive	VBN
cord-016523-pznw2ciu	120	25	activator	activator	NN
cord-016523-pznw2ciu	120	26	of	of	IN
cord-016523-pznw2ciu	120	27	caspase	caspase	NN
cord-016523-pznw2ciu	120	28	/	/	SYM
cord-016523-pznw2ciu	120	29	direct	direct	JJ
cord-016523-pznw2ciu	120	30	IAP	IAP	NNP
cord-016523-pznw2ciu	120	31	-	-	HYPH
cord-016523-pznw2ciu	120	32	binding	bind	VBG
cord-016523-pznw2ciu	120	33	protein	protein	NN
cord-016523-pznw2ciu	120	34	with	with	IN
cord-016523-pznw2ciu	120	35	low	low	JJ
cord-016523-pznw2ciu	120	36	PI	pi	NN
cord-016523-pznw2ciu	120	37	)	)	-RRB-
cord-016523-pznw2ciu	120	38	by	by	IN
cord-016523-pznw2ciu	120	39	the	the	DT
cord-016523-pznw2ciu	120	40	mitochondrion	mitochondrion	NN
cord-016523-pznw2ciu	120	41	[	[	-LRB-
cord-016523-pznw2ciu	120	42	85	85	CD
cord-016523-pznw2ciu	120	43	,	,	,
cord-016523-pznw2ciu	120	44	86	86	CD
cord-016523-pznw2ciu	120	45	]	]	-RRB-
cord-016523-pznw2ciu	120	46	,	,	,
cord-016523-pznw2ciu	120	47	explaining	explain	VBG
cord-016523-pznw2ciu	120	48	why	why	WRB
cord-016523-pznw2ciu	120	49	type	type	NN
cord-016523-pznw2ciu	120	50	II	ii	CD
cord-016523-pznw2ciu	120	51	cells	cell	NNS
cord-016523-pznw2ciu	120	52	are	be	VBP
cord-016523-pznw2ciu	120	53	more	more	RBR
cord-016523-pznw2ciu	120	54	addicted	addicted	JJ
cord-016523-pznw2ciu	120	55	to	to	IN
cord-016523-pznw2ciu	120	56	this	this	DT
cord-016523-pznw2ciu	120	57	organelle	organelle	NN
cord-016523-pznw2ciu	120	58	compared	compare	VBN
cord-016523-pznw2ciu	120	59	to	to	IN
cord-016523-pznw2ciu	120	60	type	type	NN
cord-016523-pznw2ciu	120	61	I	-PRON-	PRP
cord-016523-pznw2ciu	120	62	cells	cell	NNS
cord-016523-pznw2ciu	120	63	(	(	-LRB-
cord-016523-pznw2ciu	120	64	Fig	fig	NN
cord-016523-pznw2ciu	120	65	.	.	.
cord-016523-pznw2ciu	120	66	9.2	9.2	CD
cord-016523-pznw2ciu	120	67	)	)	-RRB-
cord-016523-pznw2ciu	120	68	.	.	.
cord-016523-pznw2ciu	121	1	To	to	TO
cord-016523-pznw2ciu	121	2	summarize	summarize	VB
cord-016523-pznw2ciu	121	3	,	,	,
cord-016523-pznw2ciu	121	4	DISC	disc	VB
cord-016523-pznw2ciu	121	5	formation	formation	NN
cord-016523-pznw2ciu	121	6	and	and	CC
cord-016523-pznw2ciu	121	7	IAP	IAP	NNP
cord-016523-pznw2ciu	121	8	amount	amount	NN
cord-016523-pznw2ciu	121	9	are	be	VBP
cord-016523-pznw2ciu	121	10	two	two	CD
cord-016523-pznw2ciu	121	11	cellular	cellular	JJ
cord-016523-pznw2ciu	121	12	markers	marker	NNS
cord-016523-pznw2ciu	121	13	allowing	allow	VBG
cord-016523-pznw2ciu	121	14	a	a	DT
cord-016523-pznw2ciu	121	15	clear	clear	JJ
cord-016523-pznw2ciu	121	16	discrimination	discrimination	NN
cord-016523-pznw2ciu	121	17	between	between	IN
cord-016523-pznw2ciu	121	18	type	type	NN
cord-016523-pznw2ciu	121	19	I	-PRON-	PRP
cord-016523-pznw2ciu	121	20	and	and	CC
cord-016523-pznw2ciu	121	21	type	type	NN
cord-016523-pznw2ciu	121	22	II	ii	CD
cord-016523-pznw2ciu	121	23	cells	cell	NNS
cord-016523-pznw2ciu	121	24	.	.	.
cord-016523-pznw2ciu	122	1	Even	even	RB
cord-016523-pznw2ciu	122	2	though	though	IN
cord-016523-pznw2ciu	122	3	IAP	IAP	NNP
cord-016523-pznw2ciu	122	4	overexpression	overexpression	NN
cord-016523-pznw2ciu	122	5	can	can	MD
cord-016523-pznw2ciu	122	6	account	account	VB
cord-016523-pznw2ciu	122	7	for	for	IN
cord-016523-pznw2ciu	122	8	the	the	DT
cord-016523-pznw2ciu	122	9	mitochondrion	mitochondrion	NN
cord-016523-pznw2ciu	122	10	dependency	dependency	NN
cord-016523-pznw2ciu	122	11	observed	observe	VBN
cord-016523-pznw2ciu	122	12	in	in	IN
cord-016523-pznw2ciu	122	13	type	type	NN
cord-016523-pznw2ciu	122	14	II	ii	CD
cord-016523-pznw2ciu	122	15	cells	cell	NNS
cord-016523-pznw2ciu	122	16	,	,	,
cord-016523-pznw2ciu	122	17	it	-PRON-	PRP
cord-016523-pznw2ciu	122	18	remains	remain	VBZ
cord-016523-pznw2ciu	122	19	unclear	unclear	JJ
cord-016523-pznw2ciu	122	20	why	why	WRB
cord-016523-pznw2ciu	122	21	DISC	disc	NN
cord-016523-pznw2ciu	122	22	formation	formation	NN
cord-016523-pznw2ciu	122	23	is	be	VBZ
cord-016523-pznw2ciu	122	24	hampered	hamper	VBN
cord-016523-pznw2ciu	122	25	in	in	IN
cord-016523-pznw2ciu	122	26	type	type	NN
cord-016523-pznw2ciu	122	27	II	ii	CD
cord-016523-pznw2ciu	122	28	cells	cell	NNS
cord-016523-pznw2ciu	122	29	and/or	and/or	CC
cord-016523-pznw2ciu	122	30	enhanced	enhance	VBN
cord-016523-pznw2ciu	122	31	in	in	IN
cord-016523-pznw2ciu	122	32	their	-PRON-	PRP$
cord-016523-pznw2ciu	122	33	type	type	NN
cord-016523-pznw2ciu	122	34	I	-PRON-	PRP
cord-016523-pznw2ciu	122	35	counterparts	counterpart	NNS
cord-016523-pznw2ciu	122	36	.	.	.
cord-016523-pznw2ciu	123	1	Recently	recently	RB
cord-016523-pznw2ciu	123	2	,	,	,
cord-016523-pznw2ciu	123	3	high	high	JJ
cord-016523-pznw2ciu	123	4	activity	activity	NN
cord-016523-pznw2ciu	123	5	of	of	IN
cord-016523-pznw2ciu	123	6	the	the	DT
cord-016523-pznw2ciu	123	7	lipid	lipid	NN
cord-016523-pznw2ciu	123	8	kinase	kinase	NN
cord-016523-pznw2ciu	123	9	phosphoinositide	phosphoinositide	NNP
cord-016523-pznw2ciu	123	10	3-kinase	3-kinase	CD
cord-016523-pznw2ciu	123	11	(	(	-LRB-
cord-016523-pznw2ciu	123	12	PI3	PI3	NNP
cord-016523-pznw2ciu	123	13	K	K	NNP
cord-016523-pznw2ciu	123	14	)	)	-RRB-
cord-016523-pznw2ciu	123	15	or	or	CC
cord-016523-pznw2ciu	123	16	downregulation	downregulation	NN
cord-016523-pznw2ciu	123	17	of	of	IN
cord-016523-pznw2ciu	123	18	its	-PRON-	PRP$
cord-016523-pznw2ciu	123	19	neutralizing	neutralize	VBG
cord-016523-pznw2ciu	123	20	phosphatase	phosphatase	NN
cord-016523-pznw2ciu	123	21	,	,	,
cord-016523-pznw2ciu	123	22	phosphatase	phosphatase	NN
cord-016523-pznw2ciu	123	23	and	and	CC
cord-016523-pznw2ciu	123	24	tensin	tensin	NNP
cord-016523-pznw2ciu	123	25	homologue	homologue	NN
cord-016523-pznw2ciu	123	26	on	on	IN
cord-016523-pznw2ciu	123	27	chromosome	chromosome	NN
cord-016523-pznw2ciu	123	28	10	10	CD
cord-016523-pznw2ciu	123	29	(	(	-LRB-
cord-016523-pznw2ciu	123	30	PTEN	PTEN	NNP
cord-016523-pznw2ciu	123	31	)	)	-RRB-
cord-016523-pznw2ciu	123	32	,	,	,
cord-016523-pznw2ciu	123	33	was	be	VBD
cord-016523-pznw2ciu	123	34	found	find	VBN
cord-016523-pznw2ciu	123	35	in	in	IN
cord-016523-pznw2ciu	123	36	type	type	NN
cord-016523-pznw2ciu	123	37	II	ii	CD
cord-016523-pznw2ciu	123	38	cells	cell	NNS
cord-016523-pznw2ciu	123	39	,	,	,
cord-016523-pznw2ciu	123	40	while	while	IN
cord-016523-pznw2ciu	123	41	this	this	DT
cord-016523-pznw2ciu	123	42	signal	signal	NN
cord-016523-pznw2ciu	123	43	is	be	VBZ
cord-016523-pznw2ciu	123	44	blocked	block	VBN
cord-016523-pznw2ciu	123	45	in	in	IN
cord-016523-pznw2ciu	123	46	type	type	NN
cord-016523-pznw2ciu	123	47	I	-PRON-	PRP
cord-016523-pznw2ciu	123	48	cell	cell	NN
cord-016523-pznw2ciu	123	49	lines	line	NNS
cord-016523-pznw2ciu	123	50	[	[	-LRB-
cord-016523-pznw2ciu	123	51	87	87	CD
cord-016523-pznw2ciu	123	52	,	,	,
cord-016523-pznw2ciu	123	53	88	88	CD
cord-016523-pznw2ciu	123	54	]	]	-RRB-
cord-016523-pznw2ciu	123	55	.	.	.
cord-016523-pznw2ciu	124	1	The	the	DT
cord-016523-pznw2ciu	124	2	PI3	pi3	NN
cord-016523-pznw2ciu	124	3	K	K	NNP
cord-016523-pznw2ciu	124	4	signaling	signal	VBG
cord-016523-pznw2ciu	124	5	pathway	pathway	NN
cord-016523-pznw2ciu	124	6	was	be	VBD
cord-016523-pznw2ciu	124	7	reported	report	VBN
cord-016523-pznw2ciu	124	8	to	to	TO
cord-016523-pznw2ciu	124	9	prevent	prevent	VB
cord-016523-pznw2ciu	124	10	the	the	DT
cord-016523-pznw2ciu	124	11	aggregation	aggregation	NN
cord-016523-pznw2ciu	124	12	of	of	IN
cord-016523-pznw2ciu	124	13	CD95	CD95	NNP
cord-016523-pznw2ciu	124	14	[	[	-LRB-
cord-016523-pznw2ciu	124	15	89	89	CD
cord-016523-pznw2ciu	124	16	]	]	-RRB-
cord-016523-pznw2ciu	124	17	,	,	,
cord-016523-pznw2ciu	124	18	probably	probably	RB
cord-016523-pznw2ciu	124	19	by	by	IN
cord-016523-pznw2ciu	124	20	retaining	retain	VBG
cord-016523-pznw2ciu	124	21	the	the	DT
cord-016523-pznw2ciu	124	22	receptor	receptor	NN
cord-016523-pznw2ciu	124	23	outside	outside	IN
cord-016523-pznw2ciu	124	24	of	of	IN
cord-016523-pznw2ciu	124	25	lipid	lipid	NN
cord-016523-pznw2ciu	124	26	rafts	raft	NNS
cord-016523-pznw2ciu	124	27	[	[	-LRB-
cord-016523-pznw2ciu	124	28	87	87	CD
cord-016523-pznw2ciu	124	29	,	,	,
cord-016523-pznw2ciu	124	30	90	90	CD
cord-016523-pznw2ciu	124	31	]	]	-RRB-
cord-016523-pznw2ciu	124	32	.	.	.
cord-016523-pznw2ciu	125	1	PEA-15	PEA-15	NNP
cord-016523-pznw2ciu	125	2	,	,	,
cord-016523-pznw2ciu	125	3	also	also	RB
cord-016523-pznw2ciu	125	4	known	know	VBN
cord-016523-pznw2ciu	125	5	as	as	IN
cord-016523-pznw2ciu	125	6	PED	PED	NNP
cord-016523-pznw2ciu	125	7	,	,	,
cord-016523-pznw2ciu	125	8	is	be	VBZ
cord-016523-pznw2ciu	125	9	a	a	DT
cord-016523-pznw2ciu	125	10	protein	protein	NN
cord-016523-pznw2ciu	125	11	containing	contain	VBG
cord-016523-pznw2ciu	125	12	a	a	DT
cord-016523-pznw2ciu	125	13	death	death	NN
cord-016523-pznw2ciu	125	14	effector	effector	NN
cord-016523-pznw2ciu	125	15	domain	domain	NN
cord-016523-pznw2ciu	125	16	(	(	-LRB-
cord-016523-pznw2ciu	125	17	DED	DED	NNP
cord-016523-pznw2ciu	125	18	)	)	-RRB-
cord-016523-pznw2ciu	125	19	that	that	WDT
cord-016523-pznw2ciu	125	20	has	have	VBZ
cord-016523-pznw2ciu	125	21	been	be	VBN
cord-016523-pznw2ciu	125	22	shown	show	VBN
cord-016523-pznw2ciu	125	23	to	to	TO
cord-016523-pznw2ciu	125	24	inhibit	inhibit	VB
cord-016523-pznw2ciu	125	25	the	the	DT
cord-016523-pznw2ciu	125	26	CD95	CD95	NNP
cord-016523-pznw2ciu	125	27	and	and	CC
cord-016523-pznw2ciu	125	28	TNFR1	TNFR1	NNP
cord-016523-pznw2ciu	125	29	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	125	30	signals	signal	NNS
cord-016523-pznw2ciu	125	31	(	(	-LRB-
cord-016523-pznw2ciu	125	32	Fig	Fig	NNP
cord-016523-pznw2ciu	125	33	.	.	.
cord-016523-pznw2ciu	125	34	9	9	CD
cord-016523-pznw2ciu	125	35	.	.	CD
cord-016523-pznw2ciu	125	36	2	2	LS
cord-016523-pznw2ciu	125	37	)	)	-RRB-
cord-016523-pznw2ciu	126	1	[	[	-LRB-
cord-016523-pznw2ciu	126	2	74	74	CD
cord-016523-pznw2ciu	126	3	]	]	-RRB-
cord-016523-pznw2ciu	126	4	.	.	.
cord-016523-pznw2ciu	127	1	Activation	activation	NN
cord-016523-pznw2ciu	127	2	of	of	IN
cord-016523-pznw2ciu	127	3	PI3	PI3	NNP
cord-016523-pznw2ciu	127	4	K	K	NNP
cord-016523-pznw2ciu	127	5	and	and	CC
cord-016523-pznw2ciu	127	6	its	-PRON-	PRP$
cord-016523-pznw2ciu	127	7	downstream	downstream	JJ
cord-016523-pznw2ciu	127	8	effector	effector	NN
cord-016523-pznw2ciu	127	9	,	,	,
cord-016523-pznw2ciu	127	10	serine	serine	NN
cord-016523-pznw2ciu	127	11	-	-	HYPH
cord-016523-pznw2ciu	127	12	threonine	threonine	NN
cord-016523-pznw2ciu	127	13	kinase	kinase	NN
cord-016523-pznw2ciu	127	14	Akt	Akt	NNP
cord-016523-pznw2ciu	127	15	,	,	,
cord-016523-pznw2ciu	127	16	leads	lead	VBZ
cord-016523-pznw2ciu	127	17	to	to	IN
cord-016523-pznw2ciu	127	18	phosphorylation	phosphorylation	NN
cord-016523-pznw2ciu	127	19	of	of	IN
cord-016523-pznw2ciu	127	20	PEA-15	PEA-15	NNP
cord-016523-pznw2ciu	127	21	at	at	IN
cord-016523-pznw2ciu	127	22	serine	serine	NN
cord-016523-pznw2ciu	127	23	116	116	CD
cord-016523-pznw2ciu	127	24	[	[	-LRB-
cord-016523-pznw2ciu	127	25	87	87	CD
cord-016523-pznw2ciu	127	26	,	,	,
cord-016523-pznw2ciu	127	27	90	90	CD
cord-016523-pznw2ciu	127	28	]	]	-RRB-
cord-016523-pznw2ciu	127	29	;	;	:
cord-016523-pznw2ciu	127	30	this	this	DT
cord-016523-pznw2ciu	127	31	posttranslational	posttranslational	JJ
cord-016523-pznw2ciu	127	32	modifi	modifi	NNP
cord-016523-pznw2ciu	127	33	cation	cation	NN
cord-016523-pznw2ciu	127	34	promotes	promote	VBZ
cord-016523-pznw2ciu	127	35	its	-PRON-	PRP$
cord-016523-pznw2ciu	127	36	interaction	interaction	NN
cord-016523-pznw2ciu	127	37	with	with	IN
cord-016523-pznw2ciu	127	38	FADD	FADD	NNP
cord-016523-pznw2ciu	127	39	,	,	,
cord-016523-pznw2ciu	127	40	ultimately	ultimately	RB
cord-016523-pznw2ciu	127	41	inhibiting	inhibit	VBG
cord-016523-pznw2ciu	127	42	DISC	disc	NN
cord-016523-pznw2ciu	127	43	formation	formation	NN
cord-016523-pznw2ciu	127	44	[	[	-LRB-
cord-016523-pznw2ciu	127	45	91	91	CD
cord-016523-pznw2ciu	127	46	,	,	,
cord-016523-pznw2ciu	127	47	92	92	CD
cord-016523-pznw2ciu	127	48	]	]	-RRB-
cord-016523-pznw2ciu	127	49	.	.	.
cord-016523-pznw2ciu	128	1	Notably	notably	RB
cord-016523-pznw2ciu	128	2	,	,	,
cord-016523-pznw2ciu	128	3	the	the	DT
cord-016523-pznw2ciu	128	4	existence	existence	NN
cord-016523-pznw2ciu	128	5	of	of	IN
cord-016523-pznw2ciu	128	6	type	type	NN
cord-016523-pznw2ciu	128	7	I	-PRON-	PRP
cord-016523-pznw2ciu	128	8	and	and	CC
cord-016523-pznw2ciu	128	9	type	type	NN
cord-016523-pznw2ciu	128	10	II	ii	CD
cord-016523-pznw2ciu	128	11	cells	cell	NNS
cord-016523-pznw2ciu	128	12	is	be	VBZ
cord-016523-pznw2ciu	128	13	not	not	RB
cord-016523-pznw2ciu	128	14	only	only	RB
cord-016523-pznw2ciu	128	15	an	an	DT
cord-016523-pznw2ciu	128	16	in	in	IN
cord-016523-pznw2ciu	128	17	vitro	vitro	FW
cord-016523-pznw2ciu	128	18	observation	observation	NN
cord-016523-pznw2ciu	128	19	,	,	,
cord-016523-pznw2ciu	128	20	but	but	CC
cord-016523-pznw2ciu	128	21	has	have	VBZ
cord-016523-pznw2ciu	128	22	been	be	VBN
cord-016523-pznw2ciu	128	23	identifi	identifi	VBN
cord-016523-pznw2ciu	128	24	ed	ed	NNP
cord-016523-pznw2ciu	128	25	physiologically	physiologically	RB
cord-016523-pznw2ciu	128	26	in	in	IN
cord-016523-pznw2ciu	128	27	human	human	JJ
cord-016523-pznw2ciu	128	28	body	body	NN
cord-016523-pznw2ciu	128	29	.	.	.
cord-016523-pznw2ciu	129	1	CD95-mediated	cd95-mediated	CD
cord-016523-pznw2ciu	129	2	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	129	3	signal	signal	NN
cord-016523-pznw2ciu	129	4	can	can	MD
cord-016523-pznw2ciu	129	5	not	not	RB
cord-016523-pznw2ciu	129	6	be	be	VB
cord-016523-pznw2ciu	129	7	altered	alter	VBN
cord-016523-pznw2ciu	129	8	in	in	IN
cord-016523-pznw2ciu	129	9	thymocytes	thymocyte	NNS
cord-016523-pznw2ciu	129	10	or	or	CC
cord-016523-pznw2ciu	129	11	activated	activate	VBN
cord-016523-pznw2ciu	129	12	T	T	NNP
cord-016523-pznw2ciu	129	13	cells	cell	NNS
cord-016523-pznw2ciu	129	14	expressing	express	VBG
cord-016523-pznw2ciu	129	15	a	a	DT
cord-016523-pznw2ciu	129	16	Bcl-2	Bcl-2	NNP
cord-016523-pznw2ciu	129	17	transgene	transgene	NN
cord-016523-pznw2ciu	129	18	,	,	,
cord-016523-pznw2ciu	129	19	conferring	confer	VBG
cord-016523-pznw2ciu	129	20	to	to	IN
cord-016523-pznw2ciu	129	21	their	-PRON-	PRP$
cord-016523-pznw2ciu	129	22	type	type	NN
cord-016523-pznw2ciu	129	23	I	-PRON-	PRP
cord-016523-pznw2ciu	129	24	nature	nature	VBP
cord-016523-pznw2ciu	129	25	[	[	-LRB-
cord-016523-pznw2ciu	129	26	93	93	CD
cord-016523-pznw2ciu	129	27	]	]	-RRB-
cord-016523-pznw2ciu	129	28	,	,	,
cord-016523-pznw2ciu	129	29	whereas	whereas	IN
cord-016523-pznw2ciu	129	30	hepatocytes	hepatocyte	NNS
cord-016523-pznw2ciu	129	31	expressing	express	VBG
cord-016523-pznw2ciu	129	32	the	the	DT
cord-016523-pznw2ciu	129	33	same	same	JJ
cord-016523-pznw2ciu	129	34	transgene	transgene	NN
cord-016523-pznw2ciu	129	35	resist	resist	NN
cord-016523-pznw2ciu	129	36	CD95-induced	cd95-induced	CD
cord-016523-pznw2ciu	129	37	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	129	38	and	and	CC
cord-016523-pznw2ciu	129	39	thus	thus	RB
cord-016523-pznw2ciu	129	40	behave	behave	VB
cord-016523-pznw2ciu	129	41	as	as	IN
cord-016523-pznw2ciu	129	42	type	type	NN
cord-016523-pznw2ciu	129	43	II	ii	CD
cord-016523-pznw2ciu	129	44	cells	cell	NNS
cord-016523-pznw2ciu	129	45	[	[	-LRB-
cord-016523-pznw2ciu	129	46	94	94	CD
cord-016523-pznw2ciu	129	47	,	,	,
cord-016523-pznw2ciu	129	48	95	95	CD
cord-016523-pznw2ciu	129	49	]	]	-RRB-
cord-016523-pznw2ciu	129	50	.	.	.
cord-016523-pznw2ciu	130	1	Germinal	germinal	JJ
cord-016523-pznw2ciu	130	2	mutations	mutation	NNS
cord-016523-pznw2ciu	130	3	in	in	IN
cord-016523-pznw2ciu	130	4	APT	APT	NNP
cord-016523-pznw2ciu	130	5	-1	-1	NNP
cord-016523-pznw2ciu	130	6	have	have	VBP
cord-016523-pznw2ciu	130	7	been	be	VBN
cord-016523-pznw2ciu	130	8	reported	report	VBN
cord-016523-pznw2ciu	130	9	in	in	IN
cord-016523-pznw2ciu	130	10	patients	patient	NNS
cord-016523-pznw2ciu	130	11	developing	develop	VBG
cord-016523-pznw2ciu	130	12	a	a	DT
cord-016523-pznw2ciu	130	13	syndrome	syndrome	NN
cord-016523-pznw2ciu	130	14	termed	term	VBN
cord-016523-pznw2ciu	130	15	autoimmune	autoimmune	JJ
cord-016523-pznw2ciu	130	16	lymphoproliferative	lymphoproliferative	JJ
cord-016523-pznw2ciu	130	17	syndrome	syndrome	NN
cord-016523-pznw2ciu	130	18	type	type	NN
cord-016523-pznw2ciu	130	19	Ia	Ia	NNP
cord-016523-pznw2ciu	130	20	(	(	-LRB-
cord-016523-pznw2ciu	130	21	ALPS	ALPS	NNP
cord-016523-pznw2ciu	130	22	,	,	,
cord-016523-pznw2ciu	130	23	also	also	RB
cord-016523-pznw2ciu	130	24	called	call	VBN
cord-016523-pznw2ciu	130	25	Canale	Canale	NNP
cord-016523-pznw2ciu	130	26	-	-	HYPH
cord-016523-pznw2ciu	130	27	Smith	Smith	NNP
cord-016523-pznw2ciu	130	28	syndrome	syndrome	NN
cord-016523-pznw2ciu	130	29	)	)	-RRB-
cord-016523-pznw2ciu	130	30	[	[	-LRB-
cord-016523-pznw2ciu	130	31	96	96	CD
cord-016523-pznw2ciu	130	32	-98	-98	NNS
cord-016523-pznw2ciu	130	33	]	]	-RRB-
cord-016523-pznw2ciu	130	34	.	.	.
cord-016523-pznw2ciu	131	1	ALPS	ALPS	NNP
cord-016523-pznw2ciu	131	2	patients	patient	NNS
cord-016523-pznw2ciu	131	3	show	show	VBP
cord-016523-pznw2ciu	131	4	chronic	chronic	JJ
cord-016523-pznw2ciu	131	5	lymphadenopathy	lymphadenopathy	NN
cord-016523-pznw2ciu	131	6	and	and	CC
cord-016523-pznw2ciu	131	7	splenomegaly	splenomegaly	NN
cord-016523-pznw2ciu	131	8	,	,	,
cord-016523-pznw2ciu	131	9	expanded	expand	VBN
cord-016523-pznw2ciu	131	10	populations	population	NNS
cord-016523-pznw2ciu	131	11	of	of	IN
cord-016523-pznw2ciu	131	12	double	double	JJ
cord-016523-pznw2ciu	131	13	-	-	HYPH
cord-016523-pznw2ciu	131	14	negative	negative	JJ
cord-016523-pznw2ciu	131	15	α	α	NN
cord-016523-pznw2ciu	131	16	/	/	SYM
cord-016523-pznw2ciu	131	17	β	β	NN
cord-016523-pznw2ciu	131	18	Τ	τ	NN
cord-016523-pznw2ciu	131	19	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	131	20	(	(	-LRB-
cord-016523-pznw2ciu	131	21	CD3	CD3	NNP
cord-016523-pznw2ciu	131	22	+	+	SYM
cord-016523-pznw2ciu	131	23	CD4	CD4	NNP
cord-016523-pznw2ciu	131	24	−	−	NNP
cord-016523-pznw2ciu	131	25	CD8	CD8	NNP
cord-016523-pznw2ciu	131	26	−	−	NNP
cord-016523-pznw2ciu	131	27	)	)	-RRB-
cord-016523-pznw2ciu	131	28	,	,	,
cord-016523-pznw2ciu	131	29	and	and	CC
cord-016523-pznw2ciu	131	30	often	often	RB
cord-016523-pznw2ciu	131	31	develop	develop	VBP
cord-016523-pznw2ciu	131	32	autoimmunity	autoimmunity	NN
cord-016523-pznw2ciu	131	33	[	[	-LRB-
cord-016523-pznw2ciu	131	34	96	96	CD
cord-016523-pznw2ciu	131	35	,	,	,
cord-016523-pznw2ciu	131	36	97	97	CD
cord-016523-pznw2ciu	131	37	,	,	,
cord-016523-pznw2ciu	131	38	99	99	CD
cord-016523-pznw2ciu	131	39	,	,	,
cord-016523-pznw2ciu	131	40	100	100	CD
cord-016523-pznw2ciu	131	41	]	]	-RRB-
cord-016523-pznw2ciu	131	42	.	.	.
cord-016523-pznw2ciu	132	1	In	in	IN
cord-016523-pznw2ciu	132	2	agreement	agreement	NN
cord-016523-pznw2ciu	132	3	with	with	IN
cord-016523-pznw2ciu	132	4	the	the	DT
cord-016523-pznw2ciu	132	5	notion	notion	NN
cord-016523-pznw2ciu	132	6	that	that	IN
cord-016523-pznw2ciu	132	7	CD95	CD95	NNP
cord-016523-pznw2ciu	132	8	behaves	behave	VBZ
cord-016523-pznw2ciu	132	9	as	as	IN
cord-016523-pznw2ciu	132	10	a	a	DT
cord-016523-pznw2ciu	132	11	tumor	tumor	NN
cord-016523-pznw2ciu	132	12	suppressor	suppressor	NN
cord-016523-pznw2ciu	132	13	,	,	,
cord-016523-pznw2ciu	132	14	ALPS	ALPS	NNP
cord-016523-pznw2ciu	132	15	patients	patient	NNS
cord-016523-pznw2ciu	132	16	display	display	VBP
cord-016523-pznw2ciu	132	17	an	an	DT
cord-016523-pznw2ciu	132	18	increased	increase	VBN
cord-016523-pznw2ciu	132	19	risk	risk	NN
cord-016523-pznw2ciu	132	20	of	of	IN
cord-016523-pznw2ciu	132	21	Hodgkin	Hodgkin	NNP
cord-016523-pznw2ciu	132	22	and	and	CC
cord-016523-pznw2ciu	132	23	non	non	JJ
cord-016523-pznw2ciu	132	24	-	-	JJ
cord-016523-pznw2ciu	132	25	Hodgkin	Hodgkin	NNP
cord-016523-pznw2ciu	132	26	lymphoma	lymphoma	NN
cord-016523-pznw2ciu	132	27	[	[	-LRB-
cord-016523-pznw2ciu	132	28	101	101	CD
cord-016523-pznw2ciu	132	29	]	]	-RRB-
cord-016523-pznw2ciu	132	30	.	.	.
cord-016523-pznw2ciu	133	1	Predominance	predominance	NN
cord-016523-pznw2ciu	133	2	of	of	IN
cord-016523-pznw2ciu	133	3	post	post	JJ
cord-016523-pznw2ciu	133	4	-	-	JJ
cord-016523-pznw2ciu	133	5	germinal	germinal	JJ
cord-016523-pznw2ciu	133	6	center	center	NN
cord-016523-pznw2ciu	133	7	(	(	-LRB-
cord-016523-pznw2ciu	133	8	GC	GC	NNP
cord-016523-pznw2ciu	133	9	)	)	-RRB-
cord-016523-pznw2ciu	133	10	lymphomas	lymphoma	NNS
cord-016523-pznw2ciu	133	11	in	in	IN
cord-016523-pznw2ciu	133	12	patients	patient	NNS
cord-016523-pznw2ciu	133	13	exhibiting	exhibit	VBG
cord-016523-pznw2ciu	133	14	either	either	CC
cord-016523-pznw2ciu	133	15	germ	germ	NN
cord-016523-pznw2ciu	133	16	line	line	NN
cord-016523-pznw2ciu	133	17	or	or	CC
cord-016523-pznw2ciu	133	18	somatic	somatic	JJ
cord-016523-pznw2ciu	133	19	CD95	CD95	NNP
cord-016523-pznw2ciu	133	20	mutations	mutation	NNS
cord-016523-pznw2ciu	133	21	can	can	MD
cord-016523-pznw2ciu	133	22	be	be	VB
cord-016523-pznw2ciu	133	23	explained	explain	VBN
cord-016523-pznw2ciu	133	24	by	by	IN
cord-016523-pznw2ciu	133	25	the	the	DT
cord-016523-pznw2ciu	133	26	fact	fact	NN
cord-016523-pznw2ciu	133	27	that	that	IN
cord-016523-pznw2ciu	133	28	,	,	,
cord-016523-pznw2ciu	133	29	inside	inside	IN
cord-016523-pznw2ciu	133	30	germinal	germinal	JJ
cord-016523-pznw2ciu	133	31	centers	center	NNS
cord-016523-pznw2ciu	133	32	of	of	IN
cord-016523-pznw2ciu	133	33	the	the	DT
cord-016523-pznw2ciu	133	34	secondary	secondary	JJ
cord-016523-pznw2ciu	133	35	lymphoid	lymphoid	JJ
cord-016523-pznw2ciu	133	36	follicles	follicle	NNS
cord-016523-pznw2ciu	133	37	,	,	,
cord-016523-pznw2ciu	133	38	the	the	DT
cord-016523-pznw2ciu	133	39	CD95	CD95	NNP
cord-016523-pznw2ciu	133	40	signal	signal	NN
cord-016523-pznw2ciu	133	41	plays	play	VBZ
cord-016523-pznw2ciu	133	42	a	a	DT
cord-016523-pznw2ciu	133	43	pivotal	pivotal	JJ
cord-016523-pznw2ciu	133	44	role	role	NN
cord-016523-pznw2ciu	133	45	in	in	IN
cord-016523-pznw2ciu	133	46	the	the	DT
cord-016523-pznw2ciu	133	47	deletion	deletion	NN
cord-016523-pznw2ciu	133	48	of	of	IN
cord-016523-pznw2ciu	133	49	self	self	NN
cord-016523-pznw2ciu	133	50	-	-	HYPH
cord-016523-pznw2ciu	133	51	reactive	reactive	JJ
cord-016523-pznw2ciu	133	52	maturating	maturating	NN
cord-016523-pznw2ciu	133	53	B	b	NN
cord-016523-pznw2ciu	133	54	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	133	55	[	[	-LRB-
cord-016523-pznw2ciu	133	56	102	102	CD
cord-016523-pznw2ciu	133	57	]	]	-RRB-
cord-016523-pznw2ciu	133	58	,	,	,
cord-016523-pznw2ciu	133	59	in	in	IN
cord-016523-pznw2ciu	133	60	addition	addition	NN
cord-016523-pznw2ciu	133	61	to	to	IN
cord-016523-pznw2ciu	133	62	the	the	DT
cord-016523-pznw2ciu	133	63	fact	fact	NN
cord-016523-pznw2ciu	133	64	that	that	IN
cord-016523-pznw2ciu	133	65	APT1	APT1	NNP
cord-016523-pznw2ciu	133	66	belongs	belong	VBZ
cord-016523-pznw2ciu	133	67	to	to	IN
cord-016523-pznw2ciu	133	68	a	a	DT
cord-016523-pznw2ciu	133	69	set	set	NN
cord-016523-pznw2ciu	133	70	of	of	IN
cord-016523-pznw2ciu	133	71	rare	rare	JJ
cord-016523-pznw2ciu	133	72	genes	gene	NNS
cord-016523-pznw2ciu	133	73	(	(	-LRB-
cord-016523-pznw2ciu	133	74	i.e.	i.e.	FW
cord-016523-pznw2ciu	133	75	,	,	,
cord-016523-pznw2ciu	133	76	PIM1	PIM1	NNP
cord-016523-pznw2ciu	133	77	,	,	,
cord-016523-pznw2ciu	133	78	c	c	NNP
cord-016523-pznw2ciu	133	79	-	-	HYPH
cord-016523-pznw2ciu	133	80	myc	myc	NNP
cord-016523-pznw2ciu	133	81	,	,	,
cord-016523-pznw2ciu	133	82	PAX5	PAX5	NNP
cord-016523-pznw2ciu	133	83	,	,	,
cord-016523-pznw2ciu	133	84	RhoH	RhoH	NNP
cord-016523-pznw2ciu	133	85	/	/	SYM
cord-016523-pznw2ciu	133	86	TTF	TTF	NNP
cord-016523-pznw2ciu	133	87	,	,	,
cord-016523-pznw2ciu	133	88	and	and	CC
cord-016523-pznw2ciu	133	89	Bcl-6	Bcl-6	NNP
cord-016523-pznw2ciu	133	90	)	)	-RRB-
cord-016523-pznw2ciu	133	91	subject	subject	JJ
cord-016523-pznw2ciu	133	92	to	to	IN
cord-016523-pznw2ciu	133	93	somatic	somatic	JJ
cord-016523-pznw2ciu	133	94	hypermutation	hypermutation	NN
cord-016523-pznw2ciu	133	95	[	[	-LRB-
cord-016523-pznw2ciu	133	96	103	103	CD
cord-016523-pznw2ciu	133	97	,	,	,
cord-016523-pznw2ciu	133	98	104	104	CD
cord-016523-pznw2ciu	133	99	]	]	-RRB-
cord-016523-pznw2ciu	133	100	,	,	,
cord-016523-pznw2ciu	133	101	which	which	WDT
cord-016523-pznw2ciu	133	102	may	may	MD
cord-016523-pznw2ciu	133	103	affect	affect	VB
cord-016523-pznw2ciu	133	104	biological	biological	JJ
cord-016523-pznw2ciu	133	105	function	function	NN
cord-016523-pznw2ciu	133	106	.	.	.
cord-016523-pznw2ciu	134	1	In	in	IN
cord-016523-pznw2ciu	134	2	addition	addition	NN
cord-016523-pznw2ciu	134	3	to	to	IN
cord-016523-pznw2ciu	134	4	post	post	VB
cord-016523-pznw2ciu	134	5	-	-	JJ
cord-016523-pznw2ciu	134	6	GC	GC	NNP
cord-016523-pznw2ciu	134	7	lymphomas	lymphoma	NNS
cord-016523-pznw2ciu	134	8	,	,	,
cord-016523-pznw2ciu	134	9	signifi	signifi	NNP
cord-016523-pznw2ciu	134	10	ca	can	MD
cord-016523-pznw2ciu	134	11	nt	not	RB
cord-016523-pznw2ciu	134	12	amounts	amount	NNS
cord-016523-pznw2ciu	134	13	of	of	IN
cord-016523-pznw2ciu	134	14	mutations	mutation	NNS
cord-016523-pznw2ciu	134	15	in	in	IN
cord-016523-pznw2ciu	134	16	the	the	DT
cord-016523-pznw2ciu	134	17	CD95	CD95	NNP
cord-016523-pznw2ciu	134	18	gene	gene	NN
cord-016523-pznw2ciu	134	19	were	be	VBD
cord-016523-pznw2ciu	134	20	found	find	VBN
cord-016523-pznw2ciu	134	21	in	in	IN
cord-016523-pznw2ciu	134	22	tumors	tumor	NNS
cord-016523-pznw2ciu	134	23	of	of	IN
cord-016523-pznw2ciu	134	24	various	various	JJ
cord-016523-pznw2ciu	134	25	histological	histological	JJ
cord-016523-pznw2ciu	134	26	origins	origin	NNS
cord-016523-pznw2ciu	134	27	(	(	-LRB-
cord-016523-pznw2ciu	134	28	reviewed	review	VBN
cord-016523-pznw2ciu	134	29	in	in	IN
cord-016523-pznw2ciu	134	30	[	[	-LRB-
cord-016523-pznw2ciu	134	31	54	54	CD
cord-016523-pznw2ciu	134	32	]	]	-RRB-
cord-016523-pznw2ciu	134	33	)	)	-RRB-
cord-016523-pznw2ciu	134	34	.	.	.
cord-016523-pznw2ciu	135	1	Extensive	extensive	JJ
cord-016523-pznw2ciu	135	2	analysis	analysis	NN
cord-016523-pznw2ciu	135	3	of	of	IN
cord-016523-pznw2ciu	135	4	CD95	CD95	NNP
cord-016523-pznw2ciu	135	5	mutations	mutation	NNS
cord-016523-pznw2ciu	135	6	and	and	CC
cord-016523-pznw2ciu	135	7	their	-PRON-	PRP$
cord-016523-pznw2ciu	135	8	distribution	distribution	NN
cord-016523-pznw2ciu	135	9	in	in	IN
cord-016523-pznw2ciu	135	10	APT	APT	NNP
cord-016523-pznw2ciu	135	11	-1	-1	NNP
cord-016523-pznw2ciu	135	12	reveals	reveal	VBZ
cord-016523-pznw2ciu	135	13	that	that	IN
cord-016523-pznw2ciu	135	14	,	,	,
cord-016523-pznw2ciu	135	15	with	with	IN
cord-016523-pznw2ciu	135	16	some	some	DT
cord-016523-pznw2ciu	135	17	exceptions	exception	NNS
cord-016523-pznw2ciu	135	18	,	,	,
cord-016523-pznw2ciu	135	19	most	most	JJS
cord-016523-pznw2ciu	135	20	are	be	VBP
cord-016523-pznw2ciu	135	21	gathered	gather	VBN
cord-016523-pznw2ciu	135	22	in	in	IN
cord-016523-pznw2ciu	135	23	exons	exon	NNS
cord-016523-pznw2ciu	135	24	8	8	CD
cord-016523-pznw2ciu	135	25	and	and	CC
cord-016523-pznw2ciu	135	26	9	9	CD
cord-016523-pznw2ciu	135	27	encoding	encode	VBG
cord-016523-pznw2ciu	135	28	the	the	DT
cord-016523-pznw2ciu	135	29	CD95	CD95	NNP
cord-016523-pznw2ciu	135	30	intracellular	intracellular	JJ
cord-016523-pznw2ciu	135	31	region	region	NN
cord-016523-pznw2ciu	135	32	(	(	-LRB-
cord-016523-pznw2ciu	135	33	Fig	Fig	NNP
cord-016523-pznw2ciu	135	34	.	.	.
cord-016523-pznw2ciu	135	35	9	9	CD
cord-016523-pznw2ciu	135	36	.	.	.
cord-016523-pznw2ciu	136	1	3	3	LS
cord-016523-pznw2ciu	136	2	)	)	-RRB-
cord-016523-pznw2ciu	136	3	[	[	-LRB-
cord-016523-pznw2ciu	136	4	105	105	CD
cord-016523-pznw2ciu	136	5	]	]	-RRB-
cord-016523-pznw2ciu	136	6	.	.	.
cord-016523-pznw2ciu	137	1	Remarkably	remarkably	RB
cord-016523-pznw2ciu	137	2	,	,	,
cord-016523-pznw2ciu	137	3	most	most	JJS
cord-016523-pznw2ciu	137	4	of	of	IN
cord-016523-pznw2ciu	137	5	these	these	DT
cord-016523-pznw2ciu	137	6	mutations	mutation	NNS
cord-016523-pznw2ciu	137	7	are	be	VBP
cord-016523-pznw2ciu	137	8	heterozygous	heterozygous	JJ
cord-016523-pznw2ciu	137	9	,	,	,
cord-016523-pznw2ciu	137	10	mainly	mainly	RB
cord-016523-pznw2ciu	137	11	localized	localize	VBN
cord-016523-pznw2ciu	137	12	in	in	IN
cord-016523-pznw2ciu	137	13	CD95-DD	cd95-dd	NN
cord-016523-pznw2ciu	137	14	,	,	,
cord-016523-pznw2ciu	137	15	and	and	CC
cord-016523-pznw2ciu	137	16	lead	lead	VB
cord-016523-pznw2ciu	137	17	to	to	IN
cord-016523-pznw2ciu	137	18	inhibition	inhibition	NN
cord-016523-pznw2ciu	137	19	of	of	IN
cord-016523-pznw2ciu	137	20	the	the	DT
cord-016523-pznw2ciu	137	21	CD95-mediated	cd95-mediated	CD
cord-016523-pznw2ciu	137	22	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	137	23	signal	signal	NN
cord-016523-pznw2ciu	137	24	.	.	.
cord-016523-pznw2ciu	138	1	Indeed	indeed	RB
cord-016523-pznw2ciu	138	2	,	,	,
cord-016523-pznw2ciu	138	3	in	in	IN
cord-016523-pznw2ciu	138	4	agreement	agreement	NN
cord-016523-pznw2ciu	138	5	with	with	IN
cord-016523-pznw2ciu	138	6	the	the	DT
cord-016523-pznw2ciu	138	7	notion	notion	NN
cord-016523-pznw2ciu	138	8	that	that	IN
cord-016523-pznw2ciu	138	9	CD95	CD95	NNP
cord-016523-pznw2ciu	138	10	is	be	VBZ
cord-016523-pznw2ciu	138	11	expressed	express	VBN
cord-016523-pznw2ciu	138	12	at	at	IN
cord-016523-pznw2ciu	138	13	the	the	DT
cord-016523-pznw2ciu	138	14	plasma	plasma	NN
cord-016523-pznw2ciu	138	15	membrane	membrane	NN
cord-016523-pznw2ciu	138	16	as	as	IN
cord-016523-pznw2ciu	138	17	a	a	DT
cord-016523-pznw2ciu	138	18	pre	pre	JJ
cord-016523-pznw2ciu	138	19	-	-	JJ
cord-016523-pznw2ciu	138	20	associated	associated	JJ
cord-016523-pznw2ciu	138	21	homotrimer	homotrimer	NNP
cord-016523-pznw2ciu	138	22	[	[	-LRB-
cord-016523-pznw2ciu	138	23	23	23	CD
cord-016523-pznw2ciu	138	24	,	,	,
cord-016523-pznw2ciu	138	25	24	24	CD
cord-016523-pznw2ciu	138	26	]	]	-RRB-
cord-016523-pznw2ciu	138	27	,	,	,
cord-016523-pznw2ciu	138	28	formation	formation	NN
cord-016523-pznw2ciu	138	29	of	of	IN
cord-016523-pznw2ciu	138	30	heterocomplexes	heterocomplexes	JJ
cord-016523-pznw2ciu	138	31	containing	contain	VBG
cord-016523-pznw2ciu	138	32	wild	wild	JJ
cord-016523-pznw2ciu	138	33	-	-	HYPH
cord-016523-pznw2ciu	138	34	type	type	NN
cord-016523-pznw2ciu	138	35	and	and	CC
cord-016523-pznw2ciu	138	36	mutated	mutate	VBN
cord-016523-pznw2ciu	138	37	CD95	CD95	NNP
cord-016523-pznw2ciu	138	38	prevents	prevent	VBZ
cord-016523-pznw2ciu	138	39	FADD	FADD	NNP
cord-016523-pznw2ciu	138	40	recruitment	recruitment	NN
cord-016523-pznw2ciu	138	41	and	and	CC
cord-016523-pznw2ciu	138	42	abrogates	abrogate	VBZ
cord-016523-pznw2ciu	138	43	the	the	DT
cord-016523-pznw2ciu	138	44	ignition	ignition	NN
cord-016523-pznw2ciu	138	45	of	of	IN
cord-016523-pznw2ciu	138	46	the	the	DT
cord-016523-pznw2ciu	138	47	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	138	48	signal	signal	NN
cord-016523-pznw2ciu	138	49	in	in	IN
cord-016523-pznw2ciu	138	50	a	a	DT
cord-016523-pznw2ciu	138	51	dominant	dominant	JJ
cord-016523-pznw2ciu	138	52	manner	manner	NN
cord-016523-pznw2ciu	138	53	.	.	.
cord-016523-pznw2ciu	139	1	Extensive	extensive	JJ
cord-016523-pznw2ciu	139	2	analysis	analysis	NN
cord-016523-pznw2ciu	139	3	and	and	CC
cord-016523-pznw2ciu	139	4	positioning	positioning	NN
cord-016523-pznw2ciu	139	5	of	of	IN
cord-016523-pznw2ciu	139	6	various	various	JJ
cord-016523-pznw2ciu	139	7	CD95	CD95	NNP
cord-016523-pznw2ciu	139	8	mutations	mutation	NNS
cord-016523-pznw2ciu	139	9	described	describe	VBN
cord-016523-pznw2ciu	139	10	in	in	IN
cord-016523-pznw2ciu	139	11	the	the	DT
cord-016523-pznw2ciu	139	12	literature	literature	NN
cord-016523-pznw2ciu	139	13	seem	seem	VBP
cord-016523-pznw2ciu	139	14	to	to	TO
cord-016523-pznw2ciu	139	15	highlight	highlight	VB
cord-016523-pznw2ciu	139	16	mutation	mutation	NN
cord-016523-pznw2ciu	139	17	"	"	``
cord-016523-pznw2ciu	139	18	hot	hot	JJ
cord-016523-pznw2ciu	139	19	spots	spot	NNS
cord-016523-pznw2ciu	139	20	"	"	''
cord-016523-pznw2ciu	139	21	in	in	IN
cord-016523-pznw2ciu	139	22	the	the	DT
cord-016523-pznw2ciu	139	23	CD95	CD95	NNP
cord-016523-pznw2ciu	139	24	sequence	sequence	NN
cord-016523-pznw2ciu	139	25	(	(	-LRB-
cord-016523-pznw2ciu	139	26	Fig	fig	NN
cord-016523-pznw2ciu	139	27	.	.	.
cord-016523-pznw2ciu	139	28	9.3	9.3	CD
cord-016523-pznw2ciu	139	29	)	)	-RRB-
cord-016523-pznw2ciu	139	30	.	.	.
cord-016523-pznw2ciu	140	1	Among	among	IN
cord-016523-pznw2ciu	140	2	these	these	DT
cord-016523-pznw2ciu	140	3	hot	hot	JJ
cord-016523-pznw2ciu	140	4	spots	spot	NNS
cord-016523-pznw2ciu	140	5	,	,	,
cord-016523-pznw2ciu	140	6	(	(	-LRB-
cord-016523-pznw2ciu	140	7	Fig	fig	NN
cord-016523-pznw2ciu	140	8	.	.	.
cord-016523-pznw2ciu	140	9	9.3	9.3	CD
cord-016523-pznw2ciu	140	10	)	)	-RRB-
cord-016523-pznw2ciu	140	11	.	.	.
cord-016523-pznw2ciu	141	1	Strikingly	strikingly	RB
cord-016523-pznw2ciu	141	2	,	,	,
cord-016523-pznw2ciu	141	3	the	the	DT
cord-016523-pznw2ciu	141	4	pivotal	pivotal	JJ
cord-016523-pznw2ciu	141	5	role	role	NN
cord-016523-pznw2ciu	141	6	played	play	VBN
cord-016523-pznw2ciu	141	7	by	by	IN
cord-016523-pznw2ciu	141	8	these	these	DT
cord-016523-pznw2ciu	141	9	amino	amino	NN
cord-016523-pznw2ciu	141	10	acids	acid	NNS
cord-016523-pznw2ciu	141	11	in	in	IN
cord-016523-pznw2ciu	141	12	stabilization	stabilization	NN
cord-016523-pznw2ciu	141	13	or	or	CC
cord-016523-pznw2ciu	141	14	formation	formation	NN
cord-016523-pznw2ciu	141	15	of	of	IN
cord-016523-pznw2ciu	141	16	intra	intra	JJ
cord-016523-pznw2ciu	141	17	-	-	:
cord-016523-pznw2ciu	141	18	and	and	CC
cord-016523-pznw2ciu	141	19	inter	inter	NNS
cord-016523-pznw2ciu	141	20	-	-	NNS
cord-016523-pznw2ciu	141	21	bridges	bridge	NNS
cord-016523-pznw2ciu	141	22	between	between	IN
cord-016523-pznw2ciu	141	23	CD95	CD95	NNP
cord-016523-pznw2ciu	141	24	and	and	CC
cord-016523-pznw2ciu	141	25	FADD	FADD	NNP
cord-016523-pznw2ciu	141	26	may	may	MD
cord-016523-pznw2ciu	141	27	explain	explain	VB
cord-016523-pznw2ciu	141	28	these	these	DT
cord-016523-pznw2ciu	141	29	hot	hot	JJ
cord-016523-pznw2ciu	141	30	spots	spot	NNS
cord-016523-pznw2ciu	141	31	.	.	.
cord-016523-pznw2ciu	142	1	For	for	IN
cord-016523-pznw2ciu	142	2	instance	instance	NN
cord-016523-pznw2ciu	142	3	,	,	,
cord-016523-pznw2ciu	142	4	both	both	CC
cord-016523-pznw2ciu	142	5	R234	r234	RB
cord-016523-pznw2ciu	142	6	and	and	CC
cord-016523-pznw2ciu	142	7	D244	D244	NNPS
cord-016523-pznw2ciu	142	8	contribute	contribute	VB
cord-016523-pznw2ciu	142	9	to	to	IN
cord-016523-pznw2ciu	142	10	the	the	DT
cord-016523-pznw2ciu	142	11	homotypic	homotypic	JJ
cord-016523-pznw2ciu	142	12	aggregation	aggregation	NN
cord-016523-pznw2ciu	142	13	of	of	IN
cord-016523-pznw2ciu	142	14	the	the	DT
cord-016523-pznw2ciu	142	15	receptor	receptor	NN
cord-016523-pznw2ciu	142	16	and	and	CC
cord-016523-pznw2ciu	142	17	FADD	FADD	NNP
cord-016523-pznw2ciu	142	18	recruitment	recruitment	NN
cord-016523-pznw2ciu	142	19	[	[	-LRB-
cord-016523-pznw2ciu	142	20	67	67	CD
cord-016523-pznw2ciu	142	21	]	]	-RRB-
cord-016523-pznw2ciu	142	22	.	.	.
cord-016523-pznw2ciu	143	1	Nevertheless	nevertheless	RB
cord-016523-pznw2ciu	143	2	,	,	,
cord-016523-pznw2ciu	143	3	the	the	DT
cord-016523-pznw2ciu	143	4	observation	observation	NN
cord-016523-pznw2ciu	143	5	of	of	IN
cord-016523-pznw2ciu	143	6	death	death	NN
cord-016523-pznw2ciu	143	7	domain	domain	NN
cord-016523-pznw2ciu	143	8	hot	hot	JJ
cord-016523-pznw2ciu	143	9	spots	spot	NNS
cord-016523-pznw2ciu	143	10	is	be	VBZ
cord-016523-pznw2ciu	143	11	in	in	IN
cord-016523-pznw2ciu	143	12	contradiction	contradiction	NN
cord-016523-pznw2ciu	143	13	with	with	IN
cord-016523-pznw2ciu	143	14	the	the	DT
cord-016523-pznw2ciu	143	15	study	study	NN
cord-016523-pznw2ciu	143	16	of	of	IN
cord-016523-pznw2ciu	143	17	Scott	Scott	NNP
cord-016523-pznw2ciu	143	18	and	and	CC
cord-016523-pznw2ciu	143	19	colleagues	colleague	NNS
cord-016523-pznw2ciu	143	20	demonstrating	demonstrate	VBG
cord-016523-pznw2ciu	143	21	that	that	IN
cord-016523-pznw2ciu	143	22	the	the	DT
cord-016523-pznw2ciu	143	23	region	region	NN
cord-016523-pznw2ciu	143	24	of	of	IN
cord-016523-pznw2ciu	143	25	the	the	DT
cord-016523-pznw2ciu	143	26	CD95-DD	cd95-dd	NN
cord-016523-pznw2ciu	143	27	interacting	interact	VBG
cord-016523-pznw2ciu	143	28	with	with	IN
cord-016523-pznw2ciu	143	29	the	the	DT
cord-016523-pznw2ciu	143	30	FADD	FADD	NNP
cord-016523-pznw2ciu	143	31	-	-	HYPH
cord-016523-pznw2ciu	143	32	DD	DD	NNP
cord-016523-pznw2ciu	143	33	extends	extend	VBZ
cord-016523-pznw2ciu	143	34	over	over	RP
cord-016523-pznw2ciu	143	35	a	a	DT
cord-016523-pznw2ciu	143	36	disperse	disperse	NN
cord-016523-pznw2ciu	143	37	surface	surface	NN
cord-016523-pznw2ciu	143	38	through	through	IN
cord-016523-pznw2ciu	143	39	weak	weak	JJ
cord-016523-pznw2ciu	143	40	binding	bind	VBG
cord-016523-pznw2ciu	143	41	affi	affi	FW
cord-016523-pznw2ciu	143	42	nity	nity	NN
cord-016523-pznw2ciu	143	43	[	[	-LRB-
cord-016523-pznw2ciu	143	44	68	68	CD
cord-016523-pznw2ciu	143	45	]	]	-RRB-
cord-016523-pznw2ciu	143	46	.	.	.
cord-016523-pznw2ciu	144	1	Most	Most	JJS
cord-016523-pznw2ciu	144	2	ALPS	ALPS	NNP
cord-016523-pznw2ciu	144	3	type	type	NN
cord-016523-pznw2ciu	144	4	Ia	Ia	NNP
cord-016523-pznw2ciu	144	5	patients	patient	NNS
cord-016523-pznw2ciu	144	6	affected	affect	VBN
cord-016523-pznw2ciu	144	7	by	by	IN
cord-016523-pznw2ciu	144	8	malignancies	malignancy	NNS
cord-016523-pznw2ciu	144	9	do	do	VBP
cord-016523-pznw2ciu	144	10	not	not	RB
cord-016523-pznw2ciu	144	11	undergo	undergo	VB
cord-016523-pznw2ciu	144	12	loss	loss	NN
cord-016523-pznw2ciu	144	13	of	of	IN
cord-016523-pznw2ciu	144	14	heterozygosity	heterozygosity	NN
cord-016523-pznw2ciu	144	15	(	(	-LRB-
cord-016523-pznw2ciu	144	16	LOH	LOH	NNP
cord-016523-pznw2ciu	144	17	)	)	-RRB-
cord-016523-pznw2ciu	144	18	,	,	,
cord-016523-pznw2ciu	144	19	which	which	WDT
cord-016523-pznw2ciu	144	20	formed	form	VBD
cord-016523-pznw2ciu	144	21	the	the	DT
cord-016523-pznw2ciu	144	22	hypothesize	hypothesize	NN
cord-016523-pznw2ciu	144	23	that	that	IN
cord-016523-pznw2ciu	144	24	preservation	preservation	NN
cord-016523-pznw2ciu	144	25	of	of	IN
cord-016523-pznw2ciu	144	26	a	a	DT
cord-016523-pznw2ciu	144	27	wild	wild	JJ
cord-016523-pznw2ciu	144	28	-	-	HYPH
cord-016523-pznw2ciu	144	29	type	type	NN
cord-016523-pznw2ciu	144	30	allele	allele	NN
cord-016523-pznw2ciu	144	31	may	may	MD
cord-016523-pznw2ciu	144	32	contribute	contribute	VB
cord-016523-pznw2ciu	144	33	to	to	IN
cord-016523-pznw2ciu	144	34	carcinogenesis	carcinogenesis	NN
cord-016523-pznw2ciu	144	35	[	[	-LRB-
cord-016523-pznw2ciu	144	36	106	106	CD
cord-016523-pznw2ciu	144	37	,	,	,
cord-016523-pznw2ciu	144	38	107	107	CD
cord-016523-pznw2ciu	144	39	]	]	-RRB-
cord-016523-pznw2ciu	144	40	.	.	.
cord-016523-pznw2ciu	145	1	In	in	IN
cord-016523-pznw2ciu	145	2	the	the	DT
cord-016523-pznw2ciu	145	3	same	same	JJ
cord-016523-pznw2ciu	145	4	line	line	NN
cord-016523-pznw2ciu	145	5	,	,	,
cord-016523-pznw2ciu	145	6	it	-PRON-	PRP
cord-016523-pznw2ciu	145	7	was	be	VBD
cord-016523-pznw2ciu	145	8	demonstrated	demonstrate	VBN
cord-016523-pznw2ciu	145	9	that	that	IN
cord-016523-pznw2ciu	145	10	expression	expression	NN
cord-016523-pznw2ciu	145	11	of	of	IN
cord-016523-pznw2ciu	145	12	a	a	DT
cord-016523-pznw2ciu	145	13	unique	unique	JJ
cord-016523-pznw2ciu	145	14	mutated	mutate	VBN
cord-016523-pznw2ciu	145	15	CD95	CD95	NNP
cord-016523-pznw2ciu	145	16	allele	allele	NN
cord-016523-pznw2ciu	145	17	blocks	block	VBZ
cord-016523-pznw2ciu	145	18	the	the	DT
cord-016523-pznw2ciu	145	19	induction	induction	NN
cord-016523-pznw2ciu	145	20	of	of	IN
cord-016523-pznw2ciu	145	21	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	145	22	signals	signal	NNS
cord-016523-pznw2ciu	145	23	,	,	,
cord-016523-pznw2ciu	145	24	while	while	IN
cord-016523-pznw2ciu	145	25	it	-PRON-	PRP
cord-016523-pznw2ciu	145	26	fails	fail	VBZ
cord-016523-pznw2ciu	145	27	to	to	TO
cord-016523-pznw2ciu	145	28	prevent	prevent	VB
cord-016523-pznw2ciu	145	29	nonapoptotic	nonapoptotic	JJ
cord-016523-pznw2ciu	145	30	signals	signal	NNS
cord-016523-pznw2ciu	145	31	such	such	JJ
cord-016523-pznw2ciu	145	32	as	as	IN
cord-016523-pznw2ciu	145	33	NF	nf	NN
cord-016523-pznw2ciu	145	34	-	-	HYPH
cord-016523-pznw2ciu	145	35	κB	κB	NNP
cord-016523-pznw2ciu	145	36	and	and	CC
cord-016523-pznw2ciu	145	37	MAPK	MAPK	NNP
cord-016523-pznw2ciu	145	38	[	[	-LRB-
cord-016523-pznw2ciu	145	39	106	106	CD
cord-016523-pznw2ciu	145	40	,	,	,
cord-016523-pznw2ciu	145	41	107	107	CD
cord-016523-pznw2ciu	145	42	]	]	-RRB-
cord-016523-pznw2ciu	145	43	,	,	,
cord-016523-pznw2ciu	145	44	whose	whose	WP$
cord-016523-pznw2ciu	145	45	induction	induction	NN
cord-016523-pznw2ciu	145	46	promotes	promote	VBZ
cord-016523-pznw2ciu	145	47	invasiveness	invasiveness	NN
cord-016523-pznw2ciu	145	48	in	in	IN
cord-016523-pznw2ciu	145	49	tumor	tumor	NN
cord-016523-pznw2ciu	145	50	cells	cell	NNS
cord-016523-pznw2ciu	145	51	[	[	-LRB-
cord-016523-pznw2ciu	145	52	105	105	CD
cord-016523-pznw2ciu	145	53	,	,	,
cord-016523-pznw2ciu	145	54	108	108	CD
cord-016523-pznw2ciu	145	55	]	]	-RRB-
cord-016523-pznw2ciu	145	56	.	.	.
cord-016523-pznw2ciu	146	1	In	in	IN
cord-016523-pznw2ciu	146	2	addition	addition	NN
cord-016523-pznw2ciu	146	3	,	,	,
cord-016523-pznw2ciu	146	4	mutations	mutation	NNS
cord-016523-pznw2ciu	146	5	found	find	VBN
cord-016523-pznw2ciu	146	6	in	in	IN
cord-016523-pznw2ciu	146	7	the	the	DT
cord-016523-pznw2ciu	146	8	intracellular	intracellular	JJ
cord-016523-pznw2ciu	146	9	CD95-DD	CD95-DD	NNP
cord-016523-pznw2ciu	146	10	exhibit	exhibit	NN
cord-016523-pznw2ciu	146	11	a	a	DT
cord-016523-pznw2ciu	146	12	higher	high	JJR
cord-016523-pznw2ciu	146	13	penetrance	penetrance	NN
cord-016523-pznw2ciu	146	14	of	of	IN
cord-016523-pznw2ciu	146	15	ALPS	ALPS	NNP
cord-016523-pznw2ciu	146	16	phenotype	phenotype	NN
cord-016523-pznw2ciu	146	17	features	feature	VBZ
cord-016523-pznw2ciu	146	18	in	in	IN
cord-016523-pznw2ciu	146	19	mutation	mutation	NN
cord-016523-pznw2ciu	146	20	-	-	HYPH
cord-016523-pznw2ciu	146	21	bearing	bear	VBG
cord-016523-pznw2ciu	146	22	relatives	relative	NNS
cord-016523-pznw2ciu	146	23	compared	compare	VBN
cord-016523-pznw2ciu	146	24	to	to	IN
cord-016523-pznw2ciu	146	25	extracellular	extracellular	JJ
cord-016523-pznw2ciu	146	26	mutations	mutation	NNS
cord-016523-pznw2ciu	146	27	.	.	.
cord-016523-pznw2ciu	147	1	These	these	DT
cord-016523-pznw2ciu	147	2	results	result	NNS
cord-016523-pznw2ciu	147	3	suggest	suggest	VBP
cord-016523-pznw2ciu	147	4	that	that	IN
cord-016523-pznw2ciu	147	5	unlike	unlike	IN
cord-016523-pznw2ciu	147	6	DD	DD	NNP
cord-016523-pznw2ciu	147	7	mutations	mutation	NNS
cord-016523-pznw2ciu	147	8	,	,	,
cord-016523-pznw2ciu	147	9	CD95	CD95	NNP
cord-016523-pznw2ciu	147	10	mutations	mutation	NNS
cord-016523-pznw2ciu	147	11	localized	localize	VBN
cord-016523-pznw2ciu	147	12	outside	outside	IN
cord-016523-pznw2ciu	147	13	the	the	DT
cord-016523-pznw2ciu	147	14	DD	DD	NNP
cord-016523-pznw2ciu	147	15	somehow	somehow	RB
cord-016523-pznw2ciu	147	16	prevent	prevent	VBP
cord-016523-pznw2ciu	147	17	the	the	DT
cord-016523-pznw2ciu	147	18	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	147	19	signal	signal	NN
cord-016523-pznw2ciu	147	20	but	but	CC
cord-016523-pznw2ciu	147	21	may	may	MD
cord-016523-pznw2ciu	147	22	fail	fail	VB
cord-016523-pznw2ciu	147	23	to	to	TO
cord-016523-pznw2ciu	147	24	promote	promote	VB
cord-016523-pznw2ciu	147	25	non	non	JJ
cord-016523-pznw2ciu	147	26	-	-	JJ
cord-016523-pznw2ciu	147	27	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	147	28	pathways	pathway	NNS
cord-016523-pznw2ciu	147	29	,	,	,
cord-016523-pznw2ciu	147	30	which	which	WDT
cord-016523-pznw2ciu	147	31	may	may	MD
cord-016523-pznw2ciu	147	32	contribute	contribute	VB
cord-016523-pznw2ciu	147	33	to	to	IN
cord-016523-pznw2ciu	147	34	disease	disease	NN
cord-016523-pznw2ciu	147	35	aggressiveness	aggressiveness	NN
cord-016523-pznw2ciu	147	36	.	.	.
cord-016523-pznw2ciu	148	1	In	in	IN
cord-016523-pznw2ciu	148	2	addition	addition	NN
cord-016523-pznw2ciu	148	3	to	to	IN
cord-016523-pznw2ciu	148	4	CD95	CD95	NNP
cord-016523-pznw2ciu	148	5	downregulation	downregulation	NN
cord-016523-pznw2ciu	148	6	or	or	CC
cord-016523-pznw2ciu	148	7	expression	expression	NN
cord-016523-pznw2ciu	148	8	of	of	IN
cord-016523-pznw2ciu	148	9	the	the	DT
cord-016523-pznw2ciu	148	10	mutated	mutate	VBN
cord-016523-pznw2ciu	148	11	allele	allele	NN
cord-016523-pznw2ciu	148	12	of	of	IN
cord-016523-pznw2ciu	148	13	the	the	DT
cord-016523-pznw2ciu	148	14	receptor	receptor	NN
cord-016523-pznw2ciu	148	15	,	,	,
cord-016523-pznw2ciu	148	16	the	the	DT
cord-016523-pznw2ciu	148	17	plasma	plasma	NN
cord-016523-pznw2ciu	148	18	membrane	membrane	NN
cord-016523-pznw2ciu	148	19	distribution	distribution	NN
cord-016523-pznw2ciu	148	20	of	of	IN
cord-016523-pznw2ciu	148	21	CD95	CD95	NNP
cord-016523-pznw2ciu	148	22	represents	represent	VBZ
cord-016523-pznw2ciu	148	23	an	an	DT
cord-016523-pznw2ciu	148	24	additional	additional	JJ
cord-016523-pznw2ciu	148	25	pathway	pathway	NN
cord-016523-pznw2ciu	148	26	for	for	IN
cord-016523-pznw2ciu	148	27	tumor	tumor	NN
cord-016523-pznw2ciu	148	28	cells	cell	NNS
cord-016523-pznw2ciu	148	29	to	to	TO
cord-016523-pznw2ciu	148	30	develop	develop	VB
cord-016523-pznw2ciu	148	31	resistance	resistance	NN
cord-016523-pznw2ciu	148	32	to	to	IN
cord-016523-pznw2ciu	148	33	CD95L	cd95l	NN
cord-016523-pznw2ciu	148	34	-	-	HYPH
cord-016523-pznw2ciu	148	35	expressing	express	VBG
cord-016523-pznw2ciu	148	36	immune	immune	JJ
cord-016523-pznw2ciu	148	37	cells	cell	NNS
cord-016523-pznw2ciu	148	38	.	.	.
cord-016523-pznw2ciu	149	1	Indeed	indeed	RB
cord-016523-pznw2ciu	149	2	,	,	,
cord-016523-pznw2ciu	149	3	the	the	DT
cord-016523-pznw2ciu	149	4	plasma	plasma	NN
cord-016523-pznw2ciu	149	5	membrane	membrane	NN
cord-016523-pznw2ciu	149	6	is	be	VBZ
cord-016523-pznw2ciu	149	7	a	a	DT
cord-016523-pznw2ciu	149	8	heterogeneous	heterogeneous	JJ
cord-016523-pznw2ciu	149	9	lipid	lipid	NN
cord-016523-pznw2ciu	149	10	bilayer	bilayer	NN
cord-016523-pznw2ciu	149	11	comprising	comprise	VBG
cord-016523-pznw2ciu	149	12	compacted	compacted	JJ
cord-016523-pznw2ciu	149	13	or	or	CC
cord-016523-pznw2ciu	149	14	liquid	liquid	NN
cord-016523-pznw2ciu	149	15	-	-	HYPH
cord-016523-pznw2ciu	149	16	ordered	order	VBN
cord-016523-pznw2ciu	149	17	domains	domain	NNS
cord-016523-pznw2ciu	149	18	,	,	,
cord-016523-pznw2ciu	149	19	called	call	VBN
cord-016523-pznw2ciu	149	20	microdomains	microdomains	NNP
cord-016523-pznw2ciu	149	21	,	,	,
cord-016523-pznw2ciu	149	22	lipid	lipid	NN
cord-016523-pznw2ciu	149	23	rafts	raft	NNS
cord-016523-pznw2ciu	149	24	,	,	,
cord-016523-pznw2ciu	149	25	or	or	CC
cord-016523-pznw2ciu	149	26	detergent	detergent	NN
cord-016523-pznw2ciu	149	27	-	-	HYPH
cord-016523-pznw2ciu	149	28	resistant	resistant	JJ
cord-016523-pznw2ciu	149	29	microdomains	microdomain	NNS
cord-016523-pznw2ciu	149	30	(	(	-LRB-
cord-016523-pznw2ciu	149	31	DRMs	DRMs	NNP
cord-016523-pznw2ciu	149	32	)	)	-RRB-
cord-016523-pznw2ciu	149	33	.	.	.
cord-016523-pznw2ciu	150	1	These	these	DT
cord-016523-pznw2ciu	150	2	domains	domain	NNS
cord-016523-pznw2ciu	150	3	are	be	VBP
cord-016523-pznw2ciu	150	4	described	describe	VBN
cord-016523-pznw2ciu	150	5	as	as	IN
cord-016523-pznw2ciu	150	6	fl	fl	NNP
cord-016523-pznw2ciu	150	7	oating	oate	VBG
cord-016523-pznw2ciu	150	8	in	in	IN
cord-016523-pznw2ciu	150	9	a	a	DT
cord-016523-pznw2ciu	150	10	more	more	RBR
cord-016523-pznw2ciu	150	11	fl	fl	JJ
cord-016523-pznw2ciu	150	12	uid	uid	NN
cord-016523-pznw2ciu	150	13	or	or	CC
cord-016523-pznw2ciu	150	14	liquid	liquid	NN
cord-016523-pznw2ciu	150	15	-	-	HYPH
cord-016523-pznw2ciu	150	16	disordered	disordered	JJ
cord-016523-pznw2ciu	150	17	2-D	2-d	JJ
cord-016523-pznw2ciu	150	18	lipid	lipid	NN
cord-016523-pznw2ciu	150	19	bilayer	bilayer	NN
cord-016523-pznw2ciu	150	20	and	and	CC
cord-016523-pznw2ciu	150	21	are	be	VBP
cord-016523-pznw2ciu	150	22	enriched	enrich	VBN
cord-016523-pznw2ciu	150	23	in	in	IN
cord-016523-pznw2ciu	150	24	ceramides	ceramide	NNS
cord-016523-pznw2ciu	150	25	[	[	-LRB-
cord-016523-pznw2ciu	150	26	109	109	CD
cord-016523-pznw2ciu	150	27	]	]	-RRB-
cord-016523-pznw2ciu	150	28	.	.	.
cord-016523-pznw2ciu	151	1	It	-PRON-	PRP
cord-016523-pznw2ciu	151	2	has	have	VBZ
cord-016523-pznw2ciu	151	3	been	be	VBN
cord-016523-pznw2ciu	151	4	elegantly	elegantly	RB
cord-016523-pznw2ciu	151	5	shown	show	VBN
cord-016523-pznw2ciu	151	6	that	that	IN
cord-016523-pznw2ciu	151	7	while	while	IN
cord-016523-pznw2ciu	151	8	CD95	CD95	NNP
cord-016523-pznw2ciu	151	9	is	be	VBZ
cord-016523-pznw2ciu	151	10	mostly	mostly	RB
cord-016523-pznw2ciu	151	11	excluded	exclude	VBN
cord-016523-pznw2ciu	151	12	from	from	IN
cord-016523-pznw2ciu	151	13	lipid	lipid	NN
cord-016523-pznw2ciu	151	14	rafts	raft	NNS
cord-016523-pznw2ciu	151	15	in	in	IN
cord-016523-pznw2ciu	151	16	activated	activate	VBN
cord-016523-pznw2ciu	151	17	T	t	NN
cord-016523-pznw2ciu	151	18	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	151	19	,	,	,
cord-016523-pznw2ciu	151	20	TCR	TCR	NNP
cord-016523-pznw2ciu	151	21	-	-	HYPH
cord-016523-pznw2ciu	151	22	dependent	dependent	JJ
cord-016523-pznw2ciu	151	23	reactivation	reactivation	NN
cord-016523-pznw2ciu	151	24	of	of	IN
cord-016523-pznw2ciu	151	25	these	these	DT
cord-016523-pznw2ciu	151	26	cells	cell	NNS
cord-016523-pznw2ciu	151	27	leads	lead	VBZ
cord-016523-pznw2ciu	151	28	to	to	IN
cord-016523-pznw2ciu	151	29	rapid	rapid	JJ
cord-016523-pznw2ciu	151	30	distribution	distribution	NN
cord-016523-pznw2ciu	151	31	of	of	IN
cord-016523-pznw2ciu	151	32	the	the	DT
cord-016523-pznw2ciu	151	33	death	death	NN
cord-016523-pznw2ciu	151	34	receptor	receptor	NN
cord-016523-pznw2ciu	151	35	into	into	IN
cord-016523-pznw2ciu	151	36	lipid	lipid	NN
cord-016523-pznw2ciu	151	37	rafts	raft	NNS
cord-016523-pznw2ciu	151	38	[	[	-LRB-
cord-016523-pznw2ciu	151	39	110	110	CD
cord-016523-pznw2ciu	151	40	]	]	-RRB-
cord-016523-pznw2ciu	151	41	.	.	.
cord-016523-pznw2ciu	152	1	This	this	DT
cord-016523-pznw2ciu	152	2	CD95	CD95	NNP
cord-016523-pznw2ciu	152	3	compartmentalization	compartmentalization	NN
cord-016523-pznw2ciu	152	4	contributes	contribute	VBZ
cord-016523-pznw2ciu	152	5	to	to	IN
cord-016523-pznw2ciu	152	6	reducing	reduce	VBG
cord-016523-pznw2ciu	152	7	the	the	DT
cord-016523-pznw2ciu	152	8	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	152	9	threshold	threshold	NN
cord-016523-pznw2ciu	152	10	leading	lead	VBG
cord-016523-pznw2ciu	152	11	to	to	IN
cord-016523-pznw2ciu	152	12	the	the	DT
cord-016523-pznw2ciu	152	13	clonotypic	clonotypic	NNP
cord-016523-pznw2ciu	152	14	elimination	elimination	NN
cord-016523-pznw2ciu	152	15	of	of	IN
cord-016523-pznw2ciu	152	16	activated	activate	VBN
cord-016523-pznw2ciu	152	17	T	T	NNP
cord-016523-pznw2ciu	152	18	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	152	19	through	through	IN
cord-016523-pznw2ciu	152	20	activation	activation	NN
cord-016523-pznw2ciu	152	21	of	of	IN
cord-016523-pznw2ciu	152	22	the	the	DT
cord-016523-pznw2ciu	152	23	CD95-mediated	cd95-mediated	CD
cord-016523-pznw2ciu	152	24	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	152	25	signal	signal	NN
cord-016523-pznw2ciu	152	26	[	[	-LRB-
cord-016523-pznw2ciu	152	27	110	110	CD
cord-016523-pznw2ciu	152	28	]	]	-RRB-
cord-016523-pznw2ciu	152	29	.	.	.
cord-016523-pznw2ciu	153	1	Similarly	similarly	RB
cord-016523-pznw2ciu	153	2	,	,	,
cord-016523-pznw2ciu	153	3	the	the	DT
cord-016523-pznw2ciu	153	4	reorganization	reorganization	NN
cord-016523-pznw2ciu	153	5	of	of	IN
cord-016523-pznw2ciu	153	6	CD95	CD95	NNP
cord-016523-pznw2ciu	153	7	into	into	IN
cord-016523-pznw2ciu	153	8	DRMs	drm	NNS
cord-016523-pznw2ciu	153	9	can	can	MD
cord-016523-pznw2ciu	153	10	occur	occur	VB
cord-016523-pznw2ciu	153	11	independent	independent	JJ
cord-016523-pznw2ciu	153	12	from	from	IN
cord-016523-pznw2ciu	153	13	ligand	ligand	NN
cord-016523-pznw2ciu	153	14	upon	upon	IN
cord-016523-pznw2ciu	153	15	addition	addition	NN
cord-016523-pznw2ciu	153	16	of	of	IN
cord-016523-pznw2ciu	153	17	certain	certain	JJ
cord-016523-pznw2ciu	153	18	chemotherapeutic	chemotherapeutic	JJ
cord-016523-pznw2ciu	153	19	drugs	drug	NNS
cord-016523-pznw2ciu	153	20	(	(	-LRB-
cord-016523-pznw2ciu	153	21	e.g.	e.g.	RB
cord-016523-pznw2ciu	153	22	,	,	,
cord-016523-pznw2ciu	153	23	rituximab	rituximab	JJ
cord-016523-pznw2ciu	153	24	[	[	-LRB-
cord-016523-pznw2ciu	153	25	111	111	CD
cord-016523-pznw2ciu	153	26	]	]	-RRB-
cord-016523-pznw2ciu	153	27	,	,	,
cord-016523-pznw2ciu	153	28	resveratrol	resveratrol	JJ
cord-016523-pznw2ciu	153	29	[	[	-LRB-
cord-016523-pznw2ciu	153	30	112	112	CD
cord-016523-pznw2ciu	153	31	,	,	,
cord-016523-pznw2ciu	153	32	113	113	CD
cord-016523-pznw2ciu	153	33	]	]	-RRB-
cord-016523-pznw2ciu	153	34	,	,	,
cord-016523-pznw2ciu	153	35	edelfosine	edelfosine	JJ
cord-016523-pznw2ciu	153	36	[	[	-LRB-
cord-016523-pznw2ciu	153	37	87	87	CD
cord-016523-pznw2ciu	153	38	,	,	,
cord-016523-pznw2ciu	153	39	114	114	CD
cord-016523-pznw2ciu	153	40	,	,	,
cord-016523-pznw2ciu	153	41	115	115	CD
cord-016523-pznw2ciu	153	42	]	]	-RRB-
cord-016523-pznw2ciu	153	43	,	,	,
cord-016523-pznw2ciu	153	44	aplidin	aplidin	NNP
cord-016523-pznw2ciu	153	45	[	[	-LRB-
cord-016523-pznw2ciu	153	46	116	116	CD
cord-016523-pznw2ciu	153	47	]	]	-RRB-
cord-016523-pznw2ciu	153	48	,	,	,
cord-016523-pznw2ciu	153	49	perifosine	perifosine	NN
cord-016523-pznw2ciu	153	50	[	[	-LRB-
cord-016523-pznw2ciu	153	51	115	115	CD
cord-016523-pznw2ciu	153	52	]	]	-RRB-
cord-016523-pznw2ciu	153	53	,	,	,
cord-016523-pznw2ciu	153	54	cisplatin	cisplatin	JJ
cord-016523-pznw2ciu	153	55	[	[	-LRB-
cord-016523-pznw2ciu	153	56	117	117	CD
cord-016523-pznw2ciu	153	57	]	]	-RRB-
cord-016523-pznw2ciu	153	58	)	)	-RRB-
cord-016523-pznw2ciu	153	59	.	.	.
cord-016523-pznw2ciu	154	1	The	the	DT
cord-016523-pznw2ciu	154	2	molecular	molecular	JJ
cord-016523-pznw2ciu	154	3	cascades	cascade	NNS
cord-016523-pznw2ciu	154	4	that	that	WDT
cord-016523-pznw2ciu	154	5	underlie	underlie	VBP
cord-016523-pznw2ciu	155	1	this	this	DT
cord-016523-pznw2ciu	155	2	process	process	NN
cord-016523-pznw2ciu	155	3	remain	remain	VBP
cord-016523-pznw2ciu	155	4	elusive	elusive	JJ
cord-016523-pznw2ciu	155	5	.	.	.
cord-016523-pznw2ciu	156	1	Nevertheless	nevertheless	RB
cord-016523-pznw2ciu	156	2	,	,	,
cord-016523-pznw2ciu	156	3	a	a	DT
cord-016523-pznw2ciu	156	4	growing	grow	VBG
cord-016523-pznw2ciu	156	5	body	body	NN
cord-016523-pznw2ciu	156	6	of	of	IN
cord-016523-pznw2ciu	156	7	evidence	evidence	NN
cord-016523-pznw2ciu	156	8	leads	lead	VBZ
cord-016523-pznw2ciu	156	9	us	-PRON-	PRP
cord-016523-pznw2ciu	156	10	to	to	TO
cord-016523-pznw2ciu	156	11	postulate	postulate	VB
cord-016523-pznw2ciu	156	12	that	that	IN
cord-016523-pznw2ciu	156	13	alteration	alteration	NN
cord-016523-pznw2ciu	156	14	of	of	IN
cord-016523-pznw2ciu	156	15	intracellular	intracellular	JJ
cord-016523-pznw2ciu	156	16	signaling	signal	VBG
cord-016523-pznw2ciu	156	17	pathway(s	pathway(s	NN
cord-016523-pznw2ciu	156	18	)	)	-RRB-
cord-016523-pznw2ciu	156	19	,	,	,
cord-016523-pznw2ciu	156	20	such	such	JJ
cord-016523-pznw2ciu	156	21	as	as	IN
cord-016523-pznw2ciu	156	22	the	the	DT
cord-016523-pznw2ciu	156	23	aforementioned	aforementioned	JJ
cord-016523-pznw2ciu	156	24	PI3	pi3	NN
cord-016523-pznw2ciu	156	25	K	K	NNP
cord-016523-pznw2ciu	156	26	signal	signal	NN
cord-016523-pznw2ciu	156	27	[	[	-LRB-
cord-016523-pznw2ciu	156	28	87	87	CD
cord-016523-pznw2ciu	156	29	,	,	,
cord-016523-pznw2ciu	156	30	90	90	CD
cord-016523-pznw2ciu	156	31	]	]	-RRB-
cord-016523-pznw2ciu	156	32	,	,	,
cord-016523-pznw2ciu	156	33	may	may	MD
cord-016523-pznw2ciu	156	34	change	change	VB
cord-016523-pznw2ciu	156	35	biophysical	biophysical	JJ
cord-016523-pznw2ciu	156	36	properties	property	NNS
cord-016523-pznw2ciu	156	37	of	of	IN
cord-016523-pznw2ciu	156	38	the	the	DT
cord-016523-pznw2ciu	156	39	plasma	plasma	NN
cord-016523-pznw2ciu	156	40	membrane	membrane	NN
cord-016523-pznw2ciu	156	41	,	,	,
cord-016523-pznw2ciu	156	42	such	such	JJ
cord-016523-pznw2ciu	156	43	as	as	IN
cord-016523-pznw2ciu	156	44	membrane	membrane	NN
cord-016523-pznw2ciu	156	45	fl	fl	NNP
cord-016523-pznw2ciu	156	46	uidity	uidity	NNP
cord-016523-pznw2ciu	156	47	,	,	,
cord-016523-pznw2ciu	156	48	which	which	WDT
cord-016523-pznw2ciu	156	49	in	in	IN
cord-016523-pznw2ciu	156	50	turn	turn	NN
cord-016523-pznw2ciu	156	51	may	may	MD
cord-016523-pznw2ciu	156	52	facilitate	facilitate	VB
cord-016523-pznw2ciu	156	53	CD95	CD95	NNP
cord-016523-pznw2ciu	156	54	clustering	cluster	VBG
cord-016523-pznw2ciu	156	55	into	into	IN
cord-016523-pznw2ciu	156	56	large	large	JJ
cord-016523-pznw2ciu	156	57	lipid	lipid	NN
cord-016523-pznw2ciu	156	58	raft	raft	NN
cord-016523-pznw2ciu	156	59	-	-	HYPH
cord-016523-pznw2ciu	156	60	enriched	enrich	VBN
cord-016523-pznw2ciu	156	61	platforms	platform	NNS
cord-016523-pznw2ciu	156	62	,	,	,
cord-016523-pznw2ciu	156	63	favoring	favor	VBG
cord-016523-pznw2ciu	156	64	DISC	disc	NN
cord-016523-pznw2ciu	156	65	formation	formation	NN
cord-016523-pznw2ciu	156	66	and	and	CC
cord-016523-pznw2ciu	156	67	induction	induction	NN
cord-016523-pznw2ciu	156	68	of	of	IN
cord-016523-pznw2ciu	156	69	the	the	DT
cord-016523-pznw2ciu	156	70	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	156	71	program	program	NN
cord-016523-pznw2ciu	156	72	[	[	-LRB-
cord-016523-pznw2ciu	156	73	118	118	CD
cord-016523-pznw2ciu	156	74	]	]	-RRB-
cord-016523-pznw2ciu	156	75	.	.	.
cord-016523-pznw2ciu	157	1	Accumulation	accumulation	NN
cord-016523-pznw2ciu	157	2	of	of	IN
cord-016523-pznw2ciu	157	3	CD95	CD95	NNP
cord-016523-pznw2ciu	157	4	mutations	mutation	NNS
cord-016523-pznw2ciu	157	5	is	be	VBZ
cord-016523-pznw2ciu	157	6	not	not	RB
cord-016523-pznw2ciu	157	7	the	the	DT
cord-016523-pznw2ciu	157	8	only	only	JJ
cord-016523-pznw2ciu	157	9	mechanism	mechanism	NN
cord-016523-pznw2ciu	157	10	by	by	IN
cord-016523-pznw2ciu	157	11	which	which	WDT
cord-016523-pznw2ciu	157	12	malignant	malignant	JJ
cord-016523-pznw2ciu	157	13	cells	cell	NNS
cord-016523-pznw2ciu	157	14	inhibit	inhibit	VBP
cord-016523-pznw2ciu	157	15	the	the	DT
cord-016523-pznw2ciu	157	16	extrinsic	extrinsic	JJ
cord-016523-pznw2ciu	157	17	signaling	signal	VBG
cord-016523-pznw2ciu	157	18	pathway	pathway	NN
cord-016523-pznw2ciu	157	19	.	.	.
cord-016523-pznw2ciu	158	1	Posttranslational	posttranslational	JJ
cord-016523-pznw2ciu	158	2	modifi	modifi	JJ
cord-016523-pznw2ciu	158	3	cations	cation	NNS
cord-016523-pznw2ciu	158	4	in	in	IN
cord-016523-pznw2ciu	158	5	the	the	DT
cord-016523-pznw2ciu	158	6	intracellular	intracellular	JJ
cord-016523-pznw2ciu	158	7	tail	tail	NN
cord-016523-pznw2ciu	158	8	of	of	IN
cord-016523-pznw2ciu	158	9	CD95	CD95	NNP
cord-016523-pznw2ciu	158	10	,	,	,
cord-016523-pznw2ciu	158	11	such	such	JJ
cord-016523-pznw2ciu	158	12	as	as	IN
cord-016523-pznw2ciu	158	13	reversible	reversible	JJ
cord-016523-pznw2ciu	158	14	oxidation	oxidation	NN
cord-016523-pznw2ciu	158	15	or	or	CC
cord-016523-pznw2ciu	158	16	covalent	covalent	JJ
cord-016523-pznw2ciu	158	17	attachment	attachment	NN
cord-016523-pznw2ciu	158	18	of	of	IN
cord-016523-pznw2ciu	158	19	a	a	DT
cord-016523-pznw2ciu	158	20	palmitic	palmitic	JJ
cord-016523-pznw2ciu	158	21	acid	acid	NN
cord-016523-pznw2ciu	158	22	,	,	,
cord-016523-pznw2ciu	158	23	were	be	VBD
cord-016523-pznw2ciu	158	24	reported	report	VBN
cord-016523-pznw2ciu	158	25	to	to	TO
cord-016523-pznw2ciu	158	26	alter	alter	VB
cord-016523-pznw2ciu	158	27	the	the	DT
cord-016523-pznw2ciu	158	28	plasma	plasma	NN
cord-016523-pznw2ciu	158	29	membrane	membrane	NN
cord-016523-pznw2ciu	158	30	distribution	distribution	NN
cord-016523-pznw2ciu	158	31	of	of	IN
cord-016523-pznw2ciu	158	32	CD95	CD95	NNP
cord-016523-pznw2ciu	158	33	and	and	CC
cord-016523-pznw2ciu	158	34	thereby	thereby	RB
cord-016523-pznw2ciu	158	35	its	-PRON-	PRP$
cord-016523-pznw2ciu	158	36	subsequent	subsequent	JJ
cord-016523-pznw2ciu	158	37	signaling	signal	VBG
cord-016523-pznw2ciu	158	38	pathway	pathway	NN
cord-016523-pznw2ciu	158	39	.	.	.
cord-016523-pznw2ciu	159	1	For	for	IN
cord-016523-pznw2ciu	159	2	instance	instance	NN
cord-016523-pznw2ciu	159	3	,	,	,
cord-016523-pznw2ciu	159	4	S	s	NN
cord-016523-pznw2ciu	159	5	-	-	HYPH
cord-016523-pznw2ciu	159	6	glutathionylation	glutathionylation	NN
cord-016523-pznw2ciu	159	7	of	of	IN
cord-016523-pznw2ciu	159	8	mouse	mouse	NN
cord-016523-pznw2ciu	159	9	CD95	CD95	NNP
cord-016523-pznw2ciu	159	10	at	at	IN
cord-016523-pznw2ciu	159	11	cysteine	cysteine	NN
cord-016523-pznw2ciu	159	12	294	294	CD
cord-016523-pznw2ciu	159	13	promotes	promote	VBZ
cord-016523-pznw2ciu	159	14	clustering	clustering	NN
cord-016523-pznw2ciu	159	15	of	of	IN
cord-016523-pznw2ciu	159	16	CD95	CD95	NNP
cord-016523-pznw2ciu	159	17	and	and	CC
cord-016523-pznw2ciu	159	18	its	-PRON-	PRP$
cord-016523-pznw2ciu	159	19	distribution	distribution	NN
cord-016523-pznw2ciu	159	20	into	into	IN
cord-016523-pznw2ciu	159	21	lipid	lipid	NN
cord-016523-pznw2ciu	159	22	rafts	raft	NNS
cord-016523-pznw2ciu	159	23	[	[	-LRB-
cord-016523-pznw2ciu	159	24	119	119	CD
cord-016523-pznw2ciu	159	25	]	]	-RRB-
cord-016523-pznw2ciu	159	26	.	.	.
cord-016523-pznw2ciu	160	1	This	this	DT
cord-016523-pznw2ciu	160	2	amino	amino	NN
cord-016523-pznw2ciu	160	3	acid	acid	NN
cord-016523-pznw2ciu	160	4	is	be	VBZ
cord-016523-pznw2ciu	160	5	conserved	conserve	VBN
cord-016523-pznw2ciu	160	6	in	in	IN
cord-016523-pznw2ciu	160	7	the	the	DT
cord-016523-pznw2ciu	160	8	human	human	JJ
cord-016523-pznw2ciu	160	9	CD95	CD95	NNP
cord-016523-pznw2ciu	160	10	sequence	sequence	NN
cord-016523-pznw2ciu	160	11	and	and	CC
cord-016523-pznw2ciu	160	12	corresponds	correspond	VBZ
cord-016523-pznw2ciu	160	13	to	to	IN
cord-016523-pznw2ciu	160	14	cysteine	cysteine	NN
cord-016523-pznw2ciu	160	15	304	304	CD
cord-016523-pznw2ciu	160	16	(	(	-LRB-
cord-016523-pznw2ciu	160	17	or	or	CC
cord-016523-pznw2ciu	160	18	C288	C288	NNPS
cord-016523-pznw2ciu	160	19	when	when	WRB
cord-016523-pznw2ciu	160	20	subtraction	subtraction	NN
cord-016523-pznw2ciu	160	21	of	of	IN
cord-016523-pznw2ciu	160	22	the	the	DT
cord-016523-pznw2ciu	160	23	16	16	CD
cord-016523-pznw2ciu	160	24	amino	amino	NN
cord-016523-pznw2ciu	160	25	acid	acid	NN
cord-016523-pznw2ciu	160	26	signal	signal	NN
cord-016523-pznw2ciu	160	27	peptide	peptide	NN
cord-016523-pznw2ciu	160	28	is	be	VBZ
cord-016523-pznw2ciu	160	29	taken	take	VBN
cord-016523-pznw2ciu	160	30	into	into	IN
cord-016523-pznw2ciu	160	31	consideration	consideration	NN
cord-016523-pznw2ciu	160	32	[	[	-LRB-
cord-016523-pznw2ciu	160	33	12	12	CD
cord-016523-pznw2ciu	160	34	,	,	,
cord-016523-pznw2ciu	160	35	120	120	CD
cord-016523-pznw2ciu	160	36	]	]	-RRB-
cord-016523-pznw2ciu	160	37	)	)	-RRB-
cord-016523-pznw2ciu	160	38	.	.	.
cord-016523-pznw2ciu	161	1	Interestingly	interestingly	RB
cord-016523-pznw2ciu	161	2	,	,	,
cord-016523-pznw2ciu	161	3	Janssen	Janssen	NNP
cord-016523-pznw2ciu	161	4	-	-	HYPH
cord-016523-pznw2ciu	161	5	Heininger	Heininger	NNP
cord-016523-pznw2ciu	161	6	and	and	CC
cord-016523-pznw2ciu	161	7	colleagues	colleague	NNS
cord-016523-pznw2ciu	161	8	emphasize	emphasize	VBP
cord-016523-pznw2ciu	161	9	that	that	IN
cord-016523-pznw2ciu	161	10	death	death	NN
cord-016523-pznw2ciu	161	11	receptor	receptor	NN
cord-016523-pznw2ciu	161	12	glutathionylation	glutathionylation	NN
cord-016523-pznw2ciu	161	13	occurs	occur	VBZ
cord-016523-pznw2ciu	161	14	downstream	downstream	NN
cord-016523-pznw2ciu	161	15	of	of	IN
cord-016523-pznw2ciu	161	16	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	161	17	and	and	CC
cord-016523-pznw2ciu	161	18	caspase-3	caspase-3	NNP
cord-016523-pznw2ciu	161	19	activation	activation	NN
cord-016523-pznw2ciu	161	20	whose	whose	WP$
cord-016523-pznw2ciu	161	21	catalytic	catalytic	JJ
cord-016523-pznw2ciu	161	22	activity	activity	NN
cord-016523-pznw2ciu	161	23	damages	damage	VBZ
cord-016523-pznw2ciu	161	24	the	the	DT
cord-016523-pznw2ciu	161	25	thiol	thiol	NN
cord-016523-pznw2ciu	161	26	transferase	transferase	NNP
cord-016523-pznw2ciu	161	27	glutaredoxin	glutaredoxin	NNP
cord-016523-pznw2ciu	161	28	1	1	CD
cord-016523-pznw2ciu	161	29	(	(	-LRB-
cord-016523-pznw2ciu	161	30	Grx1	Grx1	NNP
cord-016523-pznw2ciu	161	31	)	)	-RRB-
cord-016523-pznw2ciu	161	32	,	,	,
cord-016523-pznw2ciu	161	33	an	an	DT
cord-016523-pznw2ciu	161	34	enzyme	enzyme	NN
cord-016523-pznw2ciu	161	35	implicated	implicate	VBN
cord-016523-pznw2ciu	161	36	in	in	IN
cord-016523-pznw2ciu	161	37	the	the	DT
cord-016523-pznw2ciu	161	38	denitrosylation	denitrosylation	NN
cord-016523-pznw2ciu	161	39	of	of	IN
cord-016523-pznw2ciu	161	40	proteins	protein	NNS
cord-016523-pznw2ciu	161	41	[	[	-LRB-
cord-016523-pznw2ciu	161	42	119	119	CD
cord-016523-pznw2ciu	161	43	]	]	-RRB-
cord-016523-pznw2ciu	161	44	.	.	.
cord-016523-pznw2ciu	162	1	The	the	DT
cord-016523-pznw2ciu	162	2	consequence	consequence	NN
cord-016523-pznw2ciu	162	3	of	of	IN
cord-016523-pznw2ciu	162	4	Grx1	Grx1	NNP
cord-016523-pznw2ciu	162	5	inactivation	inactivation	NN
cord-016523-pznw2ciu	162	6	is	be	VBZ
cord-016523-pznw2ciu	162	7	the	the	DT
cord-016523-pznw2ciu	162	8	accumulation	accumulation	NN
cord-016523-pznw2ciu	162	9	of	of	IN
cord-016523-pznw2ciu	162	10	glutathionylated	glutathionylate	VBN
cord-016523-pznw2ciu	162	11	CD95	CD95	NNP
cord-016523-pznw2ciu	162	12	,	,	,
cord-016523-pznw2ciu	162	13	which	which	WDT
cord-016523-pznw2ciu	162	14	clusters	cluster	VBZ
cord-016523-pznw2ciu	162	15	into	into	IN
cord-016523-pznw2ciu	162	16	lipid	lipid	NN
cord-016523-pznw2ciu	162	17	rafts	raft	NNS
cord-016523-pznw2ciu	162	18	,	,	,
cord-016523-pznw2ciu	162	19	sensitizing	sensitize	VBG
cord-016523-pznw2ciu	162	20	cells	cell	NNS
cord-016523-pznw2ciu	162	21	to	to	IN
cord-016523-pznw2ciu	162	22	the	the	DT
cord-016523-pznw2ciu	162	23	CD95-mediated	cd95-mediated	CD
cord-016523-pznw2ciu	162	24	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	162	25	signal	signal	NN
cord-016523-pznw2ciu	162	26	.	.	.
cord-016523-pznw2ciu	163	1	Based	base	VBN
cord-016523-pznw2ciu	163	2	on	on	IN
cord-016523-pznw2ciu	163	3	these	these	DT
cord-016523-pznw2ciu	163	4	fi	fi	NNP
cord-016523-pznw2ciu	163	5	ndings	nding	NNS
cord-016523-pznw2ciu	163	6	,	,	,
cord-016523-pznw2ciu	163	7	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	163	8	activation	activation	NN
cord-016523-pznw2ciu	163	9	occurs	occur	VBZ
cord-016523-pznw2ciu	163	10	prior	prior	RB
cord-016523-pznw2ciu	163	11	to	to	IN
cord-016523-pznw2ciu	163	12	aggregation	aggregation	NN
cord-016523-pznw2ciu	163	13	of	of	IN
cord-016523-pznw2ciu	163	14	CD95	CD95	NNP
cord-016523-pznw2ciu	163	15	and	and	CC
cord-016523-pznw2ciu	163	16	redistribution	redistribution	NN
cord-016523-pznw2ciu	163	17	into	into	IN
cord-016523-pznw2ciu	163	18	lipid	lipid	NN
cord-016523-pznw2ciu	163	19	rafts	raft	NNS
cord-016523-pznw2ciu	163	20	,	,	,
cord-016523-pznw2ciu	163	21	both	both	DT
cord-016523-pznw2ciu	163	22	of	of	IN
cord-016523-pznw2ciu	163	23	which	which	WDT
cord-016523-pznw2ciu	163	24	are	be	VBP
cord-016523-pznw2ciu	163	25	requisite	requisite	JJ
cord-016523-pznw2ciu	163	26	to	to	TO
cord-016523-pznw2ciu	163	27	form	form	VB
cord-016523-pznw2ciu	163	28	the	the	DT
cord-016523-pznw2ciu	163	29	DISC	disc	NN
cord-016523-pznw2ciu	163	30	and	and	CC
cord-016523-pznw2ciu	163	31	subsequently	subsequently	RB
cord-016523-pznw2ciu	163	32	activate	activate	VB
cord-016523-pznw2ciu	163	33	larger	large	JJR
cord-016523-pznw2ciu	163	34	amounts	amount	NNS
cord-016523-pznw2ciu	163	35	of	of	IN
cord-016523-pznw2ciu	163	36	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	163	37	.	.	.
cord-016523-pznw2ciu	164	1	In	in	IN
cord-016523-pznw2ciu	164	2	agreement	agreement	NN
cord-016523-pznw2ciu	164	3	with	with	IN
cord-016523-pznw2ciu	164	4	these	these	DT
cord-016523-pznw2ciu	164	5	observations	observation	NNS
cord-016523-pznw2ciu	164	6	,	,	,
cord-016523-pznw2ciu	164	7	activation	activation	NN
cord-016523-pznw2ciu	164	8	of	of	IN
cord-016523-pznw2ciu	164	9	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	164	10	was	be	VBD
cord-016523-pznw2ciu	164	11	reported	report	VBN
cord-016523-pznw2ciu	164	12	to	to	TO
cord-016523-pznw2ciu	164	13	occur	occur	VB
cord-016523-pznw2ciu	164	14	in	in	IN
cord-016523-pznw2ciu	164	15	a	a	DT
cord-016523-pznw2ciu	164	16	two	two	CD
cord-016523-pznw2ciu	164	17	-	-	HYPH
cord-016523-pznw2ciu	164	18	step	step	NN
cord-016523-pznw2ciu	164	19	process	process	NN
cord-016523-pznw2ciu	164	20	.	.	.
cord-016523-pznw2ciu	165	1	First	first	RB
cord-016523-pznw2ciu	165	2	,	,	,
cord-016523-pznw2ciu	165	3	an	an	DT
cord-016523-pznw2ciu	165	4	immediate	immediate	JJ
cord-016523-pznw2ciu	165	5	and	and	CC
cord-016523-pznw2ciu	165	6	small	small	JJ
cord-016523-pznw2ciu	165	7	amount	amount	NN
cord-016523-pznw2ciu	165	8	of	of	IN
cord-016523-pznw2ciu	165	9	activated	activate	VBN
cord-016523-pznw2ciu	165	10	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	165	11	(	(	-LRB-
cord-016523-pznw2ciu	165	12	<	<	NNP
cord-016523-pznw2ciu	165	13	1	1	CD
cord-016523-pznw2ciu	165	14	%	%	NN
cord-016523-pznw2ciu	165	15	)	)	-RRB-
cord-016523-pznw2ciu	165	16	is	be	VBZ
cord-016523-pznw2ciu	165	17	generated	generate	VBN
cord-016523-pznw2ciu	165	18	when	when	WRB
cord-016523-pznw2ciu	165	19	CD95L	cd95l	NN
cord-016523-pznw2ciu	165	20	interacts	interact	VBZ
cord-016523-pznw2ciu	165	21	with	with	IN
cord-016523-pznw2ciu	165	22	CD95	CD95	NNP
cord-016523-pznw2ciu	165	23	that	that	WDT
cord-016523-pznw2ciu	165	24	orchestrates	orchestrate	VBZ
cord-016523-pznw2ciu	165	25	acid	acid	NN
cord-016523-pznw2ciu	165	26	sphingomyelinase	sphingomyelinase	NN
cord-016523-pznw2ciu	165	27	(	(	-LRB-
cord-016523-pznw2ciu	165	28	ASM	ASM	NNP
cord-016523-pznw2ciu	165	29	)	)	-RRB-
cord-016523-pznw2ciu	165	30	activation	activation	NN
cord-016523-pznw2ciu	165	31	,	,	,
cord-016523-pznw2ciu	165	32	ceramide	ceramide	NN
cord-016523-pznw2ciu	165	33	production	production	NN
cord-016523-pznw2ciu	165	34	,	,	,
cord-016523-pznw2ciu	165	35	and	and	CC
cord-016523-pznw2ciu	165	36	CD95	CD95	NNP
cord-016523-pznw2ciu	165	37	clustering	clustering	NN
cord-016523-pznw2ciu	165	38	,	,	,
cord-016523-pznw2ciu	165	39	which	which	WDT
cord-016523-pznw2ciu	165	40	in	in	IN
cord-016523-pznw2ciu	165	41	turn	turn	NN
cord-016523-pznw2ciu	165	42	promote	promote	VBP
cord-016523-pznw2ciu	165	43	DISC	disc	NN
cord-016523-pznw2ciu	165	44	formation	formation	NN
cord-016523-pznw2ciu	165	45	and	and	CC
cord-016523-pznw2ciu	165	46	the	the	DT
cord-016523-pznw2ciu	165	47	outburst	outburst	NN
cord-016523-pznw2ciu	165	48	of	of	IN
cord-016523-pznw2ciu	165	49	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	165	50	processing	processing	NN
cord-016523-pznw2ciu	165	51	essential	essential	JJ
cord-016523-pznw2ciu	165	52	to	to	TO
cord-016523-pznw2ciu	165	53	mount	mount	VB
cord-016523-pznw2ciu	165	54	the	the	DT
cord-016523-pznw2ciu	165	55	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	165	56	signal	signal	NN
cord-016523-pznw2ciu	165	57	[	[	-LRB-
cord-016523-pznw2ciu	165	58	121	121	CD
cord-016523-pznw2ciu	165	59	]	]	-RRB-
cord-016523-pznw2ciu	165	60	.	.	.
cord-016523-pznw2ciu	166	1	S	S	NNP
cord-016523-pznw2ciu	166	2	-	-	HYPH
cord-016523-pznw2ciu	166	3	Glutathionylation	Glutathionylation	NNP
cord-016523-pznw2ciu	166	4	consists	consist	VBZ
cord-016523-pznw2ciu	166	5	in	in	IN
cord-016523-pznw2ciu	166	6	a	a	DT
cord-016523-pznw2ciu	166	7	bond	bond	NN
cord-016523-pznw2ciu	166	8	between	between	IN
cord-016523-pznw2ciu	166	9	a	a	DT
cord-016523-pznw2ciu	166	10	reactive	reactive	JJ
cord-016523-pznw2ciu	166	11	Cys	Cys	NNP
cord-016523-pznw2ciu	166	12	-	-	HYPH
cord-016523-pznw2ciu	166	13	thiol	thiol	NN
cord-016523-pznw2ciu	166	14	and	and	CC
cord-016523-pznw2ciu	166	15	reduced	reduce	VBN
cord-016523-pznw2ciu	166	16	glutathione	glutathione	NN
cord-016523-pznw2ciu	166	17	(	(	-LRB-
cord-016523-pznw2ciu	166	18	GSH	GSH	NNP
cord-016523-pznw2ciu	166	19	)	)	-RRB-
cord-016523-pznw2ciu	166	20	,	,	,
cord-016523-pznw2ciu	166	21	a	a	DT
cord-016523-pznw2ciu	166	22	tripeptide	tripeptide	NN
cord-016523-pznw2ciu	166	23	consisting	consist	VBG
cord-016523-pznw2ciu	166	24	of	of	IN
cord-016523-pznw2ciu	166	25	glycine	glycine	NN
cord-016523-pznw2ciu	166	26	,	,	,
cord-016523-pznw2ciu	166	27	cysteine	cysteine	NN
cord-016523-pznw2ciu	166	28	,	,	,
cord-016523-pznw2ciu	166	29	and	and	CC
cord-016523-pznw2ciu	166	30	glutamate	glutamate	NN
cord-016523-pznw2ciu	166	31	;	;	:
cord-016523-pznw2ciu	166	32	its	-PRON-	PRP$
cord-016523-pznw2ciu	166	33	attachment	attachment	NN
cord-016523-pznw2ciu	166	34	to	to	IN
cord-016523-pznw2ciu	166	35	the	the	DT
cord-016523-pznw2ciu	166	36	protein	protein	NN
cord-016523-pznw2ciu	166	37	will	will	MD
cord-016523-pznw2ciu	166	38	alter	alter	VB
cord-016523-pznw2ciu	166	39	its	-PRON-	PRP$
cord-016523-pznw2ciu	166	40	structure	structure	NN
cord-016523-pznw2ciu	166	41	and	and	CC
cord-016523-pznw2ciu	166	42	function	function	NN
cord-016523-pznw2ciu	166	43	in	in	IN
cord-016523-pznw2ciu	166	44	a	a	DT
cord-016523-pznw2ciu	166	45	manner	manner	NN
cord-016523-pznw2ciu	166	46	similar	similar	JJ
cord-016523-pznw2ciu	166	47	to	to	IN
cord-016523-pznw2ciu	166	48	the	the	DT
cord-016523-pznw2ciu	166	49	addition	addition	NN
cord-016523-pznw2ciu	166	50	of	of	IN
cord-016523-pznw2ciu	166	51	a	a	DT
cord-016523-pznw2ciu	166	52	phosphate	phosphate	NN
cord-016523-pznw2ciu	166	53	[	[	-LRB-
cord-016523-pznw2ciu	166	54	122	122	CD
cord-016523-pznw2ciu	166	55	]	]	-RRB-
cord-016523-pznw2ciu	166	56	.	.	.
cord-016523-pznw2ciu	167	1	S	S	NNP
cord-016523-pznw2ciu	167	2	-	-	HYPH
cord-016523-pznw2ciu	167	3	Glutathionylation	Glutathionylation	NNP
cord-016523-pznw2ciu	167	4	is	be	VBZ
cord-016523-pznw2ciu	167	5	not	not	RB
cord-016523-pznw2ciu	167	6	the	the	DT
cord-016523-pznw2ciu	167	7	only	only	JJ
cord-016523-pznw2ciu	167	8	posttranslational	posttranslational	JJ
cord-016523-pznw2ciu	167	9	modifi	modifi	JJ
cord-016523-pznw2ciu	167	10	cation	cation	NN
cord-016523-pznw2ciu	167	11	of	of	IN
cord-016523-pznw2ciu	167	12	CD95	CD95	NNP
cord-016523-pznw2ciu	167	13	on	on	IN
cord-016523-pznw2ciu	167	14	a	a	DT
cord-016523-pznw2ciu	167	15	cysteine	cysteine	NN
cord-016523-pznw2ciu	167	16	.	.	.
cord-016523-pznw2ciu	168	1	S	s	NN
cord-016523-pznw2ciu	168	2	-	-	HYPH
cord-016523-pznw2ciu	168	3	nitrosylation	nitrosylation	NN
cord-016523-pznw2ciu	168	4	of	of	IN
cord-016523-pznw2ciu	168	5	cysteine	cysteine	NN
cord-016523-pznw2ciu	168	6	199	199	CD
cord-016523-pznw2ciu	169	1	(	(	-LRB-
cord-016523-pznw2ciu	169	2	corresponding	correspond	VBG
cord-016523-pznw2ciu	169	3	to	to	IN
cord-016523-pznw2ciu	169	4	C183	c183	PRP
cord-016523-pznw2ciu	169	5	after	after	IN
cord-016523-pznw2ciu	169	6	subtraction	subtraction	NN
cord-016523-pznw2ciu	169	7	of	of	IN
cord-016523-pznw2ciu	169	8	signal	signal	NN
cord-016523-pznw2ciu	169	9	peptide	peptide	NN
cord-016523-pznw2ciu	169	10	sequence	sequence	NN
cord-016523-pznw2ciu	169	11	)	)	-RRB-
cord-016523-pznw2ciu	169	12	and	and	CC
cord-016523-pznw2ciu	169	13	304	304	CD
cord-016523-pznw2ciu	169	14	(	(	-LRB-
cord-016523-pznw2ciu	169	15	C288	C288	NNPS
cord-016523-pznw2ciu	169	16	)	)	-RRB-
cord-016523-pznw2ciu	169	17	in	in	IN
cord-016523-pznw2ciu	169	18	colon	colon	NN
cord-016523-pznw2ciu	169	19	and	and	CC
cord-016523-pznw2ciu	169	20	breast	breast	NN
cord-016523-pznw2ciu	169	21	tumor	tumor	NN
cord-016523-pznw2ciu	169	22	cells	cell	NNS
cord-016523-pznw2ciu	169	23	also	also	RB
cord-016523-pznw2ciu	169	24	promotes	promote	VBZ
cord-016523-pznw2ciu	169	25	the	the	DT
cord-016523-pznw2ciu	169	26	redistribution	redistribution	NN
cord-016523-pznw2ciu	169	27	of	of	IN
cord-016523-pznw2ciu	169	28	CD95	CD95	NNP
cord-016523-pznw2ciu	169	29	into	into	IN
cord-016523-pznw2ciu	169	30	DRMs	drm	NNS
cord-016523-pznw2ciu	169	31	,	,	,
cord-016523-pznw2ciu	169	32	the	the	DT
cord-016523-pznw2ciu	169	33	formation	formation	NN
cord-016523-pznw2ciu	169	34	of	of	IN
cord-016523-pznw2ciu	169	35	the	the	DT
cord-016523-pznw2ciu	169	36	DISC	disc	NN
cord-016523-pznw2ciu	169	37	,	,	,
cord-016523-pznw2ciu	169	38	and	and	CC
cord-016523-pznw2ciu	169	39	the	the	DT
cord-016523-pznw2ciu	169	40	transmission	transmission	NN
cord-016523-pznw2ciu	169	41	of	of	IN
cord-016523-pznw2ciu	169	42	the	the	DT
cord-016523-pznw2ciu	169	43	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	169	44	signal	signal	NN
cord-016523-pznw2ciu	169	45	[	[	-LRB-
cord-016523-pznw2ciu	169	46	123	123	CD
cord-016523-pznw2ciu	169	47	]	]	-RRB-
cord-016523-pznw2ciu	169	48	.	.	.
cord-016523-pznw2ciu	170	1	Two	two	CD
cord-016523-pznw2ciu	170	2	reports	report	NNS
cord-016523-pznw2ciu	170	3	have	have	VBP
cord-016523-pznw2ciu	170	4	brought	bring	VBN
cord-016523-pznw2ciu	170	5	into	into	IN
cord-016523-pznw2ciu	170	6	light	light	NN
cord-016523-pznw2ciu	170	7	that	that	DT
cord-016523-pznw2ciu	170	8	covalent	covalent	JJ
cord-016523-pznw2ciu	170	9	coupling	coupling	NN
cord-016523-pznw2ciu	170	10	of	of	IN
cord-016523-pznw2ciu	170	11	a	a	DT
cord-016523-pznw2ciu	170	12	16-carbon	16-carbon	CD
cord-016523-pznw2ciu	170	13	fatty	fatty	JJ
cord-016523-pznw2ciu	170	14	acid	acid	NN
cord-016523-pznw2ciu	170	15	(	(	-LRB-
cord-016523-pznw2ciu	170	16	palmitic	palmitic	JJ
cord-016523-pznw2ciu	170	17	acid	acid	NN
cord-016523-pznw2ciu	170	18	)	)	-RRB-
cord-016523-pznw2ciu	170	19	to	to	IN
cord-016523-pznw2ciu	170	20	cysteine	cysteine	NN
cord-016523-pznw2ciu	170	21	199	199	CD
cord-016523-pznw2ciu	171	1	(	(	-LRB-
cord-016523-pznw2ciu	171	2	C183	C183	NFP
cord-016523-pznw2ciu	171	3	)	)	-RRB-
cord-016523-pznw2ciu	171	4	elicits	elicit	VBZ
cord-016523-pznw2ciu	171	5	the	the	DT
cord-016523-pznw2ciu	171	6	redistribution	redistribution	NN
cord-016523-pznw2ciu	171	7	of	of	IN
cord-016523-pznw2ciu	171	8	CD95	CD95	NNP
cord-016523-pznw2ciu	171	9	into	into	IN
cord-016523-pznw2ciu	171	10	DRMs	drm	NNS
cord-016523-pznw2ciu	171	11	,	,	,
cord-016523-pznw2ciu	171	12	the	the	DT
cord-016523-pznw2ciu	171	13	formation	formation	NN
cord-016523-pznw2ciu	171	14	of	of	IN
cord-016523-pznw2ciu	171	15	SDS	sds	NN
cord-016523-pznw2ciu	171	16	-	-	HYPH
cord-016523-pznw2ciu	171	17	stable	stable	JJ
cord-016523-pznw2ciu	171	18	CD95	CD95	NNP
cord-016523-pznw2ciu	171	19	microaggregates	microaggregate	VBZ
cord-016523-pznw2ciu	171	20	resistant	resistant	JJ
cord-016523-pznw2ciu	171	21	to	to	IN
cord-016523-pznw2ciu	171	22	denaturing	denature	VBG
cord-016523-pznw2ciu	171	23	and	and	CC
cord-016523-pznw2ciu	171	24	reducing	reduce	VBG
cord-016523-pznw2ciu	171	25	treatments	treatment	NNS
cord-016523-pznw2ciu	171	26	,	,	,
cord-016523-pznw2ciu	171	27	and	and	CC
cord-016523-pznw2ciu	171	28	internalization	internalization	NN
cord-016523-pznw2ciu	171	29	of	of	IN
cord-016523-pznw2ciu	171	30	the	the	DT
cord-016523-pznw2ciu	171	31	receptor	receptor	NN
cord-016523-pznw2ciu	171	32	[	[	-LRB-
cord-016523-pznw2ciu	171	33	124	124	CD
cord-016523-pznw2ciu	171	34	,	,	,
cord-016523-pznw2ciu	171	35	125	125	CD
cord-016523-pznw2ciu	171	36	]	]	-RRB-
cord-016523-pznw2ciu	171	37	.	.	.
cord-016523-pznw2ciu	172	1	Although	although	IN
cord-016523-pznw2ciu	172	2	their	-PRON-	PRP$
cord-016523-pznw2ciu	172	3	order	order	NN
cord-016523-pznw2ciu	172	4	remains	remain	VBZ
cord-016523-pznw2ciu	172	5	to	to	TO
cord-016523-pznw2ciu	172	6	be	be	VB
cord-016523-pznw2ciu	172	7	fi	fi	NNP
cord-016523-pznw2ciu	172	8	ne	ne	NNP
cord-016523-pznw2ciu	172	9	-	-	HYPH
cord-016523-pznw2ciu	172	10	tuned	tune	VBN
cord-016523-pznw2ciu	172	11	,	,	,
cord-016523-pznw2ciu	172	12	these	these	DT
cord-016523-pznw2ciu	172	13	molecular	molecular	JJ
cord-016523-pznw2ciu	172	14	steps	step	NNS
cord-016523-pznw2ciu	172	15	play	play	VBP
cord-016523-pznw2ciu	172	16	a	a	DT
cord-016523-pznw2ciu	172	17	critical	critical	JJ
cord-016523-pznw2ciu	172	18	role	role	NN
cord-016523-pznw2ciu	172	19	in	in	IN
cord-016523-pznw2ciu	172	20	the	the	DT
cord-016523-pznw2ciu	172	21	implementation	implementation	NN
cord-016523-pznw2ciu	172	22	of	of	IN
cord-016523-pznw2ciu	172	23	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	172	24	signals	signal	NNS
cord-016523-pznw2ciu	172	25	.	.	.
cord-016523-pznw2ciu	173	1	Of	of	IN
cord-016523-pznw2ciu	173	2	note	note	VB
cord-016523-pznw2ciu	173	3	,	,	,
cord-016523-pznw2ciu	173	4	similar	similar	JJ
cord-016523-pznw2ciu	173	5	to	to	IN
cord-016523-pznw2ciu	173	6	S	s	NN
cord-016523-pznw2ciu	173	7	-	-	HYPH
cord-016523-pznw2ciu	173	8	nitrosylation	nitrosylation	NN
cord-016523-pznw2ciu	173	9	,	,	,
cord-016523-pznw2ciu	173	10	both	both	CC
cord-016523-pznw2ciu	173	11	the	the	DT
cord-016523-pznw2ciu	173	12	aforementioned	aforementioned	JJ
cord-016523-pznw2ciu	173	13	S	s	NN
cord-016523-pznw2ciu	173	14	-	-	HYPH
cord-016523-pznw2ciu	173	15	glutathionylation	glutathionylation	NN
cord-016523-pznw2ciu	173	16	at	at	IN
cord-016523-pznw2ciu	173	17	C304	c304	XX
cord-016523-pznw2ciu	173	18	(	(	-LRB-
cord-016523-pznw2ciu	173	19	C288	c288	$
cord-016523-pznw2ciu	173	20	)	)	-RRB-
cord-016523-pznw2ciu	173	21	and	and	CC
cord-016523-pznw2ciu	173	22	palmitoylation	palmitoylation	NN
cord-016523-pznw2ciu	173	23	at	at	IN
cord-016523-pznw2ciu	173	24	C199	C199	NNP
cord-016523-pznw2ciu	173	25	(	(	-LRB-
cord-016523-pznw2ciu	173	26	C183	C183	NNP
cord-016523-pznw2ciu	173	27	)	)	-RRB-
cord-016523-pznw2ciu	173	28	promote	promote	VB
cord-016523-pznw2ciu	173	29	the	the	DT
cord-016523-pznw2ciu	173	30	partition	partition	NN
cord-016523-pznw2ciu	173	31	of	of	IN
cord-016523-pznw2ciu	173	32	CD95	CD95	NNP
cord-016523-pznw2ciu	173	33	into	into	IN
cord-016523-pznw2ciu	173	34	lipid	lipid	NN
cord-016523-pznw2ciu	173	35	rafts	raft	NNS
cord-016523-pznw2ciu	173	36	and	and	CC
cord-016523-pznw2ciu	173	37	enhance	enhance	VB
cord-016523-pznw2ciu	173	38	the	the	DT
cord-016523-pznw2ciu	173	39	subsequent	subsequent	JJ
cord-016523-pznw2ciu	173	40	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	173	41	signal	signal	NN
cord-016523-pznw2ciu	173	42	.	.	.
cord-016523-pznw2ciu	174	1	Further	further	JJ
cord-016523-pznw2ciu	174	2	investigation	investigation	NN
cord-016523-pznw2ciu	174	3	is	be	VBZ
cord-016523-pznw2ciu	174	4	required	require	VBN
cord-016523-pznw2ciu	174	5	to	to	TO
cord-016523-pznw2ciu	174	6	address	address	VB
cord-016523-pznw2ciu	174	7	whether	whether	IN
cord-016523-pznw2ciu	174	8	these	these	DT
cord-016523-pznw2ciu	174	9	posttranslational	posttranslational	JJ
cord-016523-pznw2ciu	174	10	modifi	modifi	JJ
cord-016523-pznw2ciu	174	11	cations	cation	NNS
cord-016523-pznw2ciu	174	12	are	be	VBP
cord-016523-pznw2ciu	174	13	redundant	redundant	JJ
cord-016523-pznw2ciu	174	14	and	and	CC
cord-016523-pznw2ciu	174	15	occur	occur	VBP
cord-016523-pznw2ciu	174	16	simultaneously	simultaneously	RB
cord-016523-pznw2ciu	174	17	in	in	IN
cord-016523-pznw2ciu	174	18	dying	die	VBG
cord-016523-pznw2ciu	174	19	cells	cell	NNS
cord-016523-pznw2ciu	174	20	or	or	CC
cord-016523-pznw2ciu	174	21	are	be	VBP
cord-016523-pznw2ciu	174	22	elicited	elicit	VBN
cord-016523-pznw2ciu	174	23	in	in	IN
cord-016523-pznw2ciu	174	24	a	a	DT
cord-016523-pznw2ciu	174	25	cell	cell	NN
cord-016523-pznw2ciu	174	26	-	-	HYPH
cord-016523-pznw2ciu	174	27	specifi	specifi	VBN
cord-016523-pznw2ciu	174	28	c	c	NN
cord-016523-pznw2ciu	175	1	and/or	and/or	CC
cord-016523-pznw2ciu	175	2	in	in	IN
cord-016523-pznw2ciu	175	3	a	a	DT
cord-016523-pznw2ciu	175	4	microenvironmentspecifi	microenvironmentspecifi	NN
cord-016523-pznw2ciu	175	5	c	c	NN
cord-016523-pznw2ciu	175	6	manner	manner	NN
cord-016523-pznw2ciu	175	7	.	.	.
cord-016523-pznw2ciu	176	1	Understanding	understand	VBG
cord-016523-pznw2ciu	176	2	the	the	DT
cord-016523-pznw2ciu	176	3	molecular	molecular	JJ
cord-016523-pznw2ciu	176	4	mechanisms	mechanism	NNS
cord-016523-pznw2ciu	176	5	controlling	control	VBG
cord-016523-pznw2ciu	176	6	these	these	DT
cord-016523-pznw2ciu	176	7	posttranslational	posttranslational	JJ
cord-016523-pznw2ciu	176	8	modifi	modifi	JJ
cord-016523-pznw2ciu	176	9	cations	cation	NNS
cord-016523-pznw2ciu	176	10	would	would	MD
cord-016523-pznw2ciu	176	11	be	be	VB
cord-016523-pznw2ciu	176	12	of	of	IN
cord-016523-pznw2ciu	176	13	great	great	JJ
cord-016523-pznw2ciu	176	14	interest	interest	NN
cord-016523-pznw2ciu	176	15	in	in	IN
cord-016523-pznw2ciu	176	16	order	order	NN
cord-016523-pznw2ciu	176	17	to	to	TO
cord-016523-pznw2ciu	176	18	identify	identify	VB
cord-016523-pznw2ciu	176	19	the	the	DT
cord-016523-pznw2ciu	176	20	mechanism	mechanism	NN
cord-016523-pznw2ciu	176	21	by	by	IN
cord-016523-pznw2ciu	176	22	which	which	WDT
cord-016523-pznw2ciu	176	23	tumor	tumor	NN
cord-016523-pznw2ciu	176	24	cells	cell	NNS
cord-016523-pznw2ciu	176	25	block	block	VBP
cord-016523-pznw2ciu	176	26	them	-PRON-	PRP
cord-016523-pznw2ciu	176	27	,	,	,
cord-016523-pznw2ciu	176	28	leading	lead	VBG
cord-016523-pznw2ciu	176	29	to	to	IN
cord-016523-pznw2ciu	176	30	their	-PRON-	PRP$
cord-016523-pznw2ciu	176	31	resistance	resistance	NN
cord-016523-pznw2ciu	176	32	to	to	IN
cord-016523-pznw2ciu	176	33	the	the	DT
cord-016523-pznw2ciu	176	34	extrinsic	extrinsic	JJ
cord-016523-pznw2ciu	176	35	signaling	signal	VBG
cord-016523-pznw2ciu	176	36	pathway	pathway	NN
cord-016523-pznw2ciu	176	37	.	.	.
cord-016523-pznw2ciu	177	1	Using	use	VBG
cord-016523-pznw2ciu	177	2	a	a	DT
cord-016523-pznw2ciu	177	3	powerful	powerful	JJ
cord-016523-pznw2ciu	177	4	magnetic	magnetic	JJ
cord-016523-pznw2ciu	177	5	method	method	NN
cord-016523-pznw2ciu	177	6	to	to	TO
cord-016523-pznw2ciu	177	7	isolate	isolate	VB
cord-016523-pznw2ciu	177	8	receptor	receptor	NN
cord-016523-pznw2ciu	177	9	-	-	HYPH
cord-016523-pznw2ciu	177	10	containing	contain	VBG
cord-016523-pznw2ciu	177	11	endocytic	endocytic	JJ
cord-016523-pznw2ciu	177	12	vesicles	vesicle	NNS
cord-016523-pznw2ciu	177	13	,	,	,
cord-016523-pznw2ciu	177	14	it	-PRON-	PRP
cord-016523-pznw2ciu	177	15	has	have	VBZ
cord-016523-pznw2ciu	177	16	been	be	VBN
cord-016523-pznw2ciu	177	17	shown	show	VBN
cord-016523-pznw2ciu	177	18	that	that	IN
cord-016523-pznw2ciu	177	19	CD95	CD95	NNP
cord-016523-pznw2ciu	177	20	promptly	promptly	RB
cord-016523-pznw2ciu	177	21	associates	associate	VBZ
cord-016523-pznw2ciu	177	22	with	with	IN
cord-016523-pznw2ciu	177	23	endosomal	endosomal	NNP
cord-016523-pznw2ciu	177	24	and	and	CC
cord-016523-pznw2ciu	177	25	lysosomal	lysosomal	JJ
cord-016523-pznw2ciu	177	26	markers	marker	NNS
cord-016523-pznw2ciu	177	27	when	when	WRB
cord-016523-pznw2ciu	177	28	incubated	incubate	VBN
cord-016523-pznw2ciu	177	29	with	with	IN
cord-016523-pznw2ciu	177	30	an	an	DT
cord-016523-pznw2ciu	177	31	agonistic	agonistic	JJ
cord-016523-pznw2ciu	177	32	anti	anti	JJ
cord-016523-pznw2ciu	177	33	-	-	JJ
cord-016523-pznw2ciu	177	34	CD95	CD95	NNP
cord-016523-pznw2ciu	177	35	mAb	mAb	.
cord-016523-pznw2ciu	177	36	[	[	-LRB-
cord-016523-pznw2ciu	177	37	126	126	CD
cord-016523-pznw2ciu	177	38	]	]	-RRB-
cord-016523-pznw2ciu	177	39	.	.	.
cord-016523-pznw2ciu	178	1	In	in	IN
cord-016523-pznw2ciu	178	2	addition	addition	NN
cord-016523-pznw2ciu	178	3	,	,	,
cord-016523-pznw2ciu	178	4	expression	expression	NN
cord-016523-pznw2ciu	178	5	of	of	IN
cord-016523-pznw2ciu	178	6	a	a	DT
cord-016523-pznw2ciu	178	7	CD95	CD95	NNP
cord-016523-pznw2ciu	178	8	mutant	mutant	JJ
cord-016523-pznw2ciu	178	9	in	in	IN
cord-016523-pznw2ciu	178	10	which	which	WDT
cord-016523-pznw2ciu	178	11	the	the	DT
cord-016523-pznw2ciu	178	12	DD	DD	NNP
cord-016523-pznw2ciu	178	13	-	-	HYPH
cord-016523-pznw2ciu	178	14	located	locate	VBN
cord-016523-pznw2ciu	178	15	tyrosine	tyrosine	NN
cord-016523-pznw2ciu	178	16	291	291	CD
cord-016523-pznw2ciu	178	17	(	(	-LRB-
cord-016523-pznw2ciu	178	18	Y275	Y275	NNP
cord-016523-pznw2ciu	178	19	)	)	-RRB-
cord-016523-pznw2ciu	178	20	is	be	VBZ
cord-016523-pznw2ciu	178	21	changed	change	VBN
cord-016523-pznw2ciu	178	22	to	to	IN
cord-016523-pznw2ciu	178	23	phenylalanine	phenylalanine	NN
cord-016523-pznw2ciu	178	24	does	do	VBZ
cord-016523-pznw2ciu	178	25	not	not	RB
cord-016523-pznw2ciu	178	26	seem	seem	VB
cord-016523-pznw2ciu	178	27	to	to	TO
cord-016523-pznw2ciu	178	28	alter	alter	VB
cord-016523-pznw2ciu	178	29	the	the	DT
cord-016523-pznw2ciu	178	30	capacity	capacity	NN
cord-016523-pznw2ciu	178	31	to	to	TO
cord-016523-pznw2ciu	178	32	bind	bind	VB
cord-016523-pznw2ciu	178	33	FADD	FADD	NNP
cord-016523-pznw2ciu	178	34	but	but	CC
cord-016523-pznw2ciu	178	35	compromises	compromise	VBZ
cord-016523-pznw2ciu	178	36	CD95Lmediated	cd95lmediated	JJ
cord-016523-pznw2ciu	178	37	CD95	CD95	NNP
cord-016523-pznw2ciu	178	38	internalization	internalization	NN
cord-016523-pznw2ciu	178	39	occurring	occur	VBG
cord-016523-pznw2ciu	178	40	through	through	IN
cord-016523-pznw2ciu	178	41	an	an	DT
cord-016523-pznw2ciu	178	42	AP-2	AP-2	NNP
cord-016523-pznw2ciu	178	43	/	/	SYM
cord-016523-pznw2ciu	178	44	clathrin	clathrin	NN
cord-016523-pznw2ciu	178	45	-	-	HYPH
cord-016523-pznw2ciu	178	46	driven	drive	VBN
cord-016523-pznw2ciu	178	47	endocytic	endocytic	JJ
cord-016523-pznw2ciu	178	48	pathway	pathway	NN
cord-016523-pznw2ciu	178	49	[	[	-LRB-
cord-016523-pznw2ciu	178	50	126	126	CD
cord-016523-pznw2ciu	178	51	]	]	-RRB-
cord-016523-pznw2ciu	178	52	.	.	.
cord-016523-pznw2ciu	179	1	More	more	RBR
cord-016523-pznw2ciu	179	2	strikingly	strikingly	RB
cord-016523-pznw2ciu	179	3	,	,	,
cord-016523-pznw2ciu	179	4	expression	expression	NN
cord-016523-pznw2ciu	179	5	of	of	IN
cord-016523-pznw2ciu	179	6	the	the	DT
cord-016523-pznw2ciu	179	7	internalization	internalization	NN
cord-016523-pznw2ciu	179	8	-	-	HYPH
cord-016523-pznw2ciu	179	9	defective	defective	JJ
cord-016523-pznw2ciu	179	10	CD95	CD95	NNP
cord-016523-pznw2ciu	179	11	mutant	mutant	JJ
cord-016523-pznw2ciu	179	12	Y291F	Y291F	NNP
cord-016523-pznw2ciu	179	13	abrogates	abrogate	VBZ
cord-016523-pznw2ciu	179	14	the	the	DT
cord-016523-pznw2ciu	179	15	transmission	transmission	NN
cord-016523-pznw2ciu	179	16	of	of	IN
cord-016523-pznw2ciu	179	17	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	179	18	signals	signal	NNS
cord-016523-pznw2ciu	179	19	,	,	,
cord-016523-pznw2ciu	179	20	but	but	CC
cord-016523-pznw2ciu	179	21	fails	fail	VBZ
cord-016523-pznw2ciu	179	22	to	to	TO
cord-016523-pznw2ciu	179	23	alter	alter	VB
cord-016523-pznw2ciu	179	24	the	the	DT
cord-016523-pznw2ciu	179	25	non	non	JJ
cord-016523-pznw2ciu	179	26	-	-	JJ
cord-016523-pznw2ciu	179	27	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	179	28	signaling	signal	VBG
cord-016523-pznw2ciu	179	29	pathways	pathway	NNS
cord-016523-pznw2ciu	179	30	(	(	-LRB-
cord-016523-pznw2ciu	179	31	i.e.	i.e.	FW
cord-016523-pznw2ciu	179	32	,	,	,
cord-016523-pznw2ciu	179	33	NFkB	nfkb	UH
cord-016523-pznw2ciu	179	34	and	and	CC
cord-016523-pznw2ciu	179	35	ERK	ERK	NNP
cord-016523-pznw2ciu	179	36	)	)	-RRB-
cord-016523-pznw2ciu	179	37	,	,	,
cord-016523-pznw2ciu	179	38	and	and	CC
cord-016523-pznw2ciu	179	39	even	even	RB
cord-016523-pznw2ciu	179	40	promotes	promote	VBZ
cord-016523-pznw2ciu	179	41	them	-PRON-	PRP
cord-016523-pznw2ciu	179	42	(	(	-LRB-
cord-016523-pznw2ciu	179	43	Fig	Fig	NNP
cord-016523-pznw2ciu	179	44	.	.	.
cord-016523-pznw2ciu	179	45	9.3	9.3	CD
cord-016523-pznw2ciu	179	46	)	)	-RRB-
cord-016523-pznw2ciu	179	47	.	.	.
cord-016523-pznw2ciu	180	1	These	these	DT
cord-016523-pznw2ciu	180	2	fi	fi	NNP
cord-016523-pznw2ciu	180	3	ndings	nding	NNS
cord-016523-pznw2ciu	180	4	provide	provide	VBP
cord-016523-pznw2ciu	180	5	insight	insight	NN
cord-016523-pznw2ciu	180	6	into	into	IN
cord-016523-pznw2ciu	180	7	the	the	DT
cord-016523-pznw2ciu	180	8	presence	presence	NN
cord-016523-pznw2ciu	180	9	of	of	IN
cord-016523-pznw2ciu	180	10	a	a	DT
cord-016523-pznw2ciu	180	11	region	region	NN
cord-016523-pznw2ciu	180	12	in	in	IN
cord-016523-pznw2ciu	180	13	the	the	DT
cord-016523-pznw2ciu	180	14	DD	DD	NNP
cord-016523-pznw2ciu	180	15	,	,	,
cord-016523-pznw2ciu	180	16	interacting	interact	VBG
cord-016523-pznw2ciu	180	17	with	with	IN
cord-016523-pznw2ciu	180	18	AP2	AP2	NNP
cord-016523-pznw2ciu	180	19	and	and	CC
cord-016523-pznw2ciu	180	20	promoting	promote	VBG
cord-016523-pznw2ciu	180	21	a	a	DT
cord-016523-pznw2ciu	180	22	clathrin	clathrin	NN
cord-016523-pznw2ciu	180	23	-	-	HYPH
cord-016523-pznw2ciu	180	24	dependent	dependent	JJ
cord-016523-pznw2ciu	180	25	endocytic	endocytic	JJ
cord-016523-pznw2ciu	180	26	pathway	pathway	NN
cord-016523-pznw2ciu	180	27	in	in	IN
cord-016523-pznw2ciu	180	28	a	a	DT
cord-016523-pznw2ciu	180	29	FADD	FADD	NNP
cord-016523-pznw2ciu	180	30	-	-	HYPH
cord-016523-pznw2ciu	180	31	independent	independent	JJ
cord-016523-pznw2ciu	180	32	manner	manner	NN
cord-016523-pznw2ciu	180	33	.	.	.
cord-016523-pznw2ciu	181	1	Regarding	regard	VBG
cord-016523-pznw2ciu	181	2	the	the	DT
cord-016523-pznw2ciu	181	3	role	role	NN
cord-016523-pznw2ciu	181	4	of	of	IN
cord-016523-pznw2ciu	181	5	palmitoylation	palmitoylation	NN
cord-016523-pznw2ciu	181	6	in	in	IN
cord-016523-pznw2ciu	181	7	receptor	receptor	NN
cord-016523-pznw2ciu	181	8	internalization	internalization	NN
cord-016523-pznw2ciu	181	9	,	,	,
cord-016523-pznw2ciu	181	10	the	the	DT
cord-016523-pznw2ciu	181	11	interplay	interplay	NN
cord-016523-pznw2ciu	181	12	between	between	IN
cord-016523-pznw2ciu	181	13	lipid	lipid	NN
cord-016523-pznw2ciu	181	14	alteration	alteration	NN
cord-016523-pznw2ciu	181	15	and	and	CC
cord-016523-pznw2ciu	181	16	the	the	DT
cord-016523-pznw2ciu	181	17	AP2	AP2	NNP
cord-016523-pznw2ciu	181	18	/	/	SYM
cord-016523-pznw2ciu	181	19	clathrin	clathrin	NN
cord-016523-pznw2ciu	181	20	-	-	HYPH
cord-016523-pznw2ciu	181	21	driven	drive	VBN
cord-016523-pznw2ciu	181	22	internalization	internalization	NN
cord-016523-pznw2ciu	181	23	of	of	IN
cord-016523-pznw2ciu	181	24	CD95	CD95	NNP
cord-016523-pznw2ciu	181	25	remains	remain	VBZ
cord-016523-pznw2ciu	181	26	to	to	TO
cord-016523-pznw2ciu	181	27	be	be	VB
cord-016523-pznw2ciu	181	28	elucidated	elucidate	VBN
cord-016523-pznw2ciu	181	29	.	.	.
cord-016523-pznw2ciu	182	1	It	-PRON-	PRP
cord-016523-pznw2ciu	182	2	has	have	VBZ
cord-016523-pznw2ciu	182	3	been	be	VBN
cord-016523-pznw2ciu	182	4	recently	recently	RB
cord-016523-pznw2ciu	182	5	demonstrated	demonstrate	VBN
cord-016523-pznw2ciu	182	6	that	that	IN
cord-016523-pznw2ciu	182	7	CD95	CD95	NNP
cord-016523-pznw2ciu	182	8	engagement	engagement	NN
cord-016523-pznw2ciu	182	9	evokes	evoke	VBZ
cord-016523-pznw2ciu	182	10	a	a	DT
cord-016523-pznw2ciu	182	11	rapid	rapid	JJ
cord-016523-pznw2ciu	182	12	and	and	CC
cord-016523-pznw2ciu	182	13	transient	transient	JJ
cord-016523-pznw2ciu	182	14	Ca	Ca	NNP
cord-016523-pznw2ciu	182	15	2	2	CD
cord-016523-pznw2ciu	182	16	+	+	SYM
cord-016523-pznw2ciu	182	17	signaling	signaling	NN
cord-016523-pznw2ciu	182	18	,	,	,
cord-016523-pznw2ciu	182	19	which	which	WDT
cord-016523-pznw2ciu	182	20	stimulates	stimulate	VBZ
cord-016523-pznw2ciu	182	21	the	the	DT
cord-016523-pznw2ciu	182	22	recruitment	recruitment	NN
cord-016523-pznw2ciu	182	23	of	of	IN
cord-016523-pznw2ciu	182	24	protein	protein	NN
cord-016523-pznw2ciu	182	25	kinase	kinase	NN
cord-016523-pznw2ciu	182	26	C	C	NNP
cord-016523-pznw2ciu	182	27	-	-	HYPH
cord-016523-pznw2ciu	182	28	β2	β2	NNP
cord-016523-pznw2ciu	182	29	(	(	-LRB-
cord-016523-pznw2ciu	182	30	PKC	PKC	NNP
cord-016523-pznw2ciu	182	31	-	-	HYPH
cord-016523-pznw2ciu	182	32	β2	β2	NNP
cord-016523-pznw2ciu	182	33	)	)	-RRB-
cord-016523-pznw2ciu	182	34	from	from	IN
cord-016523-pznw2ciu	182	35	the	the	DT
cord-016523-pznw2ciu	182	36	cytosol	cytosol	NN
cord-016523-pznw2ciu	182	37	to	to	IN
cord-016523-pznw2ciu	182	38	the	the	DT
cord-016523-pznw2ciu	182	39	DISC	disc	NN
cord-016523-pznw2ciu	182	40	[	[	-LRB-
cord-016523-pznw2ciu	182	41	127	127	CD
cord-016523-pznw2ciu	182	42	]	]	-RRB-
cord-016523-pznw2ciu	182	43	.	.	.
cord-016523-pznw2ciu	183	1	This	this	DT
cord-016523-pznw2ciu	183	2	kinase	kinase	NN
cord-016523-pznw2ciu	183	3	transiently	transiently	RB
cord-016523-pznw2ciu	183	4	brakes	brake	VBZ
cord-016523-pznw2ciu	183	5	DISC	disc	NN
cord-016523-pznw2ciu	183	6	formation	formation	NN
cord-016523-pznw2ciu	183	7	,	,	,
cord-016523-pznw2ciu	183	8	providing	provide	VBG
cord-016523-pznw2ciu	183	9	a	a	DT
cord-016523-pznw2ciu	183	10	checkpoint	checkpoint	NN
cord-016523-pznw2ciu	183	11	before	before	IN
cord-016523-pznw2ciu	183	12	the	the	DT
cord-016523-pznw2ciu	183	13	irreversible	irreversible	JJ
cord-016523-pznw2ciu	183	14	commitment	commitment	NN
cord-016523-pznw2ciu	183	15	to	to	IN
cord-016523-pznw2ciu	183	16	cell	cell	NN
cord-016523-pznw2ciu	183	17	death	death	NN
cord-016523-pznw2ciu	183	18	[	[	-LRB-
cord-016523-pznw2ciu	183	19	128	128	CD
cord-016523-pznw2ciu	183	20	]	]	-RRB-
cord-016523-pznw2ciu	183	21	.	.	.
cord-016523-pznw2ciu	184	1	These	these	DT
cord-016523-pznw2ciu	184	2	fi	fi	NNP
cord-016523-pznw2ciu	184	3	ndings	nding	NNS
cord-016523-pznw2ciu	184	4	raised	raise	VBD
cord-016523-pznw2ciu	184	5	the	the	DT
cord-016523-pznw2ciu	184	6	following	follow	VBG
cord-016523-pznw2ciu	184	7	questions	question	NNS
cord-016523-pznw2ciu	184	8	:	:	:
cord-016523-pznw2ciu	184	9	what	what	WP
cord-016523-pznw2ciu	184	10	are	be	VBP
cord-016523-pznw2ciu	184	11	the	the	DT
cord-016523-pznw2ciu	184	12	Ca	Ca	NNP
cord-016523-pznw2ciu	184	13	2	2	CD
cord-016523-pznw2ciu	185	1	+	+	CC
cord-016523-pznw2ciu	185	2	-dependent	-dependent	JJ
cord-016523-pznw2ciu	185	3	molecular	molecular	JJ
cord-016523-pznw2ciu	185	4	mechanisms	mechanism	NNS
cord-016523-pznw2ciu	185	5	transiently	transiently	RB
cord-016523-pznw2ciu	185	6	inhibiting	inhibit	VBG
cord-016523-pznw2ciu	185	7	DISC	disc	NN
cord-016523-pznw2ciu	185	8	formation	formation	NN
cord-016523-pznw2ciu	185	9	,	,	,
cord-016523-pznw2ciu	185	10	and	and	CC
cord-016523-pznw2ciu	185	11	do	do	VB
cord-016523-pznw2ciu	185	12	tumor	tumor	NN
cord-016523-pznw2ciu	185	13	cells	cell	NNS
cord-016523-pznw2ciu	185	14	use	use	VBP
cord-016523-pznw2ciu	185	15	this	this	DT
cord-016523-pznw2ciu	185	16	signal	signal	NN
cord-016523-pznw2ciu	185	17	to	to	TO
cord-016523-pznw2ciu	185	18	escape	escape	VB
cord-016523-pznw2ciu	185	19	the	the	DT
cord-016523-pznw2ciu	185	20	immune	immune	JJ
cord-016523-pznw2ciu	185	21	response	response	NN
cord-016523-pznw2ciu	185	22	and/or	and/or	CC
cord-016523-pznw2ciu	185	23	resist	resist	VBP
cord-016523-pznw2ciu	185	24	chemotherapy	chemotherapy	NN
cord-016523-pznw2ciu	185	25	?	?	.
cord-016523-pznw2ciu	186	1	In	in	IN
cord-016523-pznw2ciu	186	2	1998	1998	CD
cord-016523-pznw2ciu	186	3	,	,	,
cord-016523-pznw2ciu	186	4	inhibition	inhibition	NN
cord-016523-pznw2ciu	186	5	of	of	IN
cord-016523-pznw2ciu	186	6	caspase	caspase	NN
cord-016523-pznw2ciu	186	7	activity	activity	NN
cord-016523-pznw2ciu	186	8	was	be	VBD
cord-016523-pznw2ciu	186	9	shown	show	VBN
cord-016523-pznw2ciu	186	10	to	to	TO
cord-016523-pznw2ciu	186	11	sensitize	sensitize	VB
cord-016523-pznw2ciu	186	12	fi	fi	NNP
cord-016523-pznw2ciu	186	13	broblastic	broblastic	JJ
cord-016523-pznw2ciu	186	14	L929	l929	JJ
cord-016523-pznw2ciu	186	15	cell	cell	NN
cord-016523-pznw2ciu	186	16	line	line	NN
cord-016523-pznw2ciu	186	17	to	to	IN
cord-016523-pznw2ciu	186	18	TNFmediated	tnfmediated	JJ
cord-016523-pznw2ciu	186	19	necrotic	necrotic	JJ
cord-016523-pznw2ciu	186	20	cell	cell	NN
cord-016523-pznw2ciu	186	21	death	death	NN
cord-016523-pznw2ciu	186	22	[	[	-LRB-
cord-016523-pznw2ciu	186	23	42	42	CD
cord-016523-pznw2ciu	186	24	]	]	-RRB-
cord-016523-pznw2ciu	186	25	.	.	.
cord-016523-pznw2ciu	187	1	With	with	IN
cord-016523-pznw2ciu	187	2	respect	respect	NN
cord-016523-pznw2ciu	187	3	to	to	IN
cord-016523-pznw2ciu	187	4	CD95	CD95	NNP
cord-016523-pznw2ciu	187	5	signal	signal	NN
cord-016523-pznw2ciu	187	6	,	,	,
cord-016523-pznw2ciu	187	7	Tschopp	Tschopp	NNP
cord-016523-pznw2ciu	187	8	et	et	NNP
cord-016523-pznw2ciu	187	9	al	al	NNP
cord-016523-pznw2ciu	187	10	.	.	NNP
cord-016523-pznw2ciu	187	11	showed	show	VBD
cord-016523-pznw2ciu	187	12	that	that	IN
cord-016523-pznw2ciu	187	13	FADD	FADD	NNP
cord-016523-pznw2ciu	187	14	and	and	CC
cord-016523-pznw2ciu	187	15	RIP1	RIP1	NNP
cord-016523-pznw2ciu	187	16	participate	participate	VBP
cord-016523-pznw2ciu	187	17	in	in	IN
cord-016523-pznw2ciu	187	18	the	the	DT
cord-016523-pznw2ciu	187	19	implementation	implementation	NN
cord-016523-pznw2ciu	187	20	of	of	IN
cord-016523-pznw2ciu	187	21	a	a	DT
cord-016523-pznw2ciu	187	22	non	non	JJ
cord-016523-pznw2ciu	187	23	-	-	JJ
cord-016523-pznw2ciu	187	24	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	187	25	signaling	signal	VBG
cord-016523-pznw2ciu	187	26	pathway	pathway	NN
cord-016523-pznw2ciu	187	27	,	,	,
cord-016523-pznw2ciu	187	28	which	which	WDT
cord-016523-pznw2ciu	187	29	leads	lead	VBZ
cord-016523-pznw2ciu	187	30	to	to	IN
cord-016523-pznw2ciu	187	31	a	a	DT
cord-016523-pznw2ciu	187	32	necrotic	necrotic	JJ
cord-016523-pznw2ciu	187	33	morphology	morphology	NN
cord-016523-pznw2ciu	187	34	without	without	IN
cord-016523-pznw2ciu	187	35	chromatin	chromatin	NN
cord-016523-pznw2ciu	187	36	condensation	condensation	NN
cord-016523-pznw2ciu	187	37	and	and	CC
cord-016523-pznw2ciu	187	38	with	with	IN
cord-016523-pznw2ciu	187	39	loss	loss	NN
cord-016523-pznw2ciu	187	40	of	of	IN
cord-016523-pznw2ciu	187	41	plasma	plasma	NN
cord-016523-pznw2ciu	187	42	membrane	membrane	NN
cord-016523-pznw2ciu	187	43	integrity	integrity	NN
cord-016523-pznw2ciu	187	44	[	[	-LRB-
cord-016523-pznw2ciu	187	45	41	41	CD
cord-016523-pznw2ciu	187	46	]	]	-RRB-
cord-016523-pznw2ciu	187	47	.	.	.
cord-016523-pznw2ciu	188	1	Of	of	IN
cord-016523-pznw2ciu	188	2	note	note	NN
cord-016523-pznw2ciu	188	3	,	,	,
cord-016523-pznw2ciu	188	4	BID	BID	VBN
cord-016523-pznw2ciu	188	5	cleavage	cleavage	NN
cord-016523-pznw2ciu	188	6	was	be	VBD
cord-016523-pznw2ciu	188	7	not	not	RB
cord-016523-pznw2ciu	188	8	observed	observe	VBN
cord-016523-pznw2ciu	188	9	in	in	IN
cord-016523-pznw2ciu	188	10	this	this	DT
cord-016523-pznw2ciu	188	11	necrotic	necrotic	JJ
cord-016523-pznw2ciu	188	12	signal	signal	NN
cord-016523-pznw2ciu	188	13	.	.	.
cord-016523-pznw2ciu	189	1	While	while	IN
cord-016523-pznw2ciu	189	2	FADD	FADD	NNP
cord-016523-pznw2ciu	189	3	plays	play	VBZ
cord-016523-pznw2ciu	189	4	a	a	DT
cord-016523-pznw2ciu	189	5	crucial	crucial	JJ
cord-016523-pznw2ciu	189	6	role	role	NN
cord-016523-pznw2ciu	189	7	in	in	IN
cord-016523-pznw2ciu	189	8	both	both	CC
cord-016523-pznw2ciu	189	9	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	189	10	and	and	CC
cord-016523-pznw2ciu	189	11	necrotic	necrotic	JJ
cord-016523-pznw2ciu	189	12	pathways	pathway	NNS
cord-016523-pznw2ciu	189	13	,	,	,
cord-016523-pznw2ciu	189	14	RIP1	rip1	NN
cord-016523-pznw2ciu	189	15	recruitment	recruitment	NN
cord-016523-pznw2ciu	189	16	to	to	IN
cord-016523-pznw2ciu	189	17	CD95	CD95	NNP
cord-016523-pznw2ciu	189	18	occurs	occur	VBZ
cord-016523-pznw2ciu	189	19	independently	independently	RB
cord-016523-pznw2ciu	189	20	of	of	IN
cord-016523-pznw2ciu	189	21	this	this	DT
cord-016523-pznw2ciu	189	22	adaptor	adaptor	NN
cord-016523-pznw2ciu	189	23	protein	protein	NN
cord-016523-pznw2ciu	189	24	.	.	.
cord-016523-pznw2ciu	190	1	Indeed	indeed	RB
cord-016523-pznw2ciu	190	2	,	,	,
cord-016523-pznw2ciu	190	3	yeast	yeast	VB
cord-016523-pznw2ciu	190	4	two	two	CD
cord-016523-pznw2ciu	190	5	-	-	HYPH
cord-016523-pznw2ciu	190	6	hybrid	hybrid	NN
cord-016523-pznw2ciu	190	7	experiments	experiment	NNS
cord-016523-pznw2ciu	190	8	showed	show	VBD
cord-016523-pznw2ciu	190	9	that	that	IN
cord-016523-pznw2ciu	190	10	RIP1	RIP1	NNP
cord-016523-pznw2ciu	190	11	can	can	MD
cord-016523-pznw2ciu	190	12	bind	bind	VB
cord-016523-pznw2ciu	190	13	directly	directly	RB
cord-016523-pznw2ciu	190	14	to	to	IN
cord-016523-pznw2ciu	190	15	the	the	DT
cord-016523-pznw2ciu	190	16	CD95	CD95	NNP
cord-016523-pznw2ciu	190	17	DD	DD	NNP
cord-016523-pznw2ciu	190	18	,	,	,
cord-016523-pznw2ciu	190	19	while	while	IN
cord-016523-pznw2ciu	190	20	this	this	DT
cord-016523-pznw2ciu	190	21	interaction	interaction	NN
cord-016523-pznw2ciu	190	22	is	be	VBZ
cord-016523-pznw2ciu	190	23	lost	lose	VBN
cord-016523-pznw2ciu	190	24	when	when	WRB
cord-016523-pznw2ciu	190	25	a	a	DT
cord-016523-pznw2ciu	190	26	bait	bait	NN
cord-016523-pznw2ciu	190	27	corresponding	correspond	VBG
cord-016523-pznw2ciu	190	28	to	to	IN
cord-016523-pznw2ciu	190	29	mutated	mutate	VBN
cord-016523-pznw2ciu	190	30	CD95-DD	cd95-dd	NN
cord-016523-pznw2ciu	190	31	(	(	-LRB-
cord-016523-pznw2ciu	190	32	replacement	replacement	NN
cord-016523-pznw2ciu	190	33	of	of	IN
cord-016523-pznw2ciu	190	34	Val	Val	NNP
cord-016523-pznw2ciu	190	35	238	238	CD
cord-016523-pznw2ciu	190	36	to	to	IN
cord-016523-pznw2ciu	190	37	Asn	Asn	NNP
cord-016523-pznw2ciu	190	38	)	)	-RRB-
cord-016523-pznw2ciu	190	39	is	be	VBZ
cord-016523-pznw2ciu	190	40	used	use	VBN
cord-016523-pznw2ciu	190	41	[	[	-LRB-
cord-016523-pznw2ciu	190	42	129	129	CD
cord-016523-pznw2ciu	190	43	]	]	-RRB-
cord-016523-pznw2ciu	190	44	.	.	.
cord-016523-pznw2ciu	191	1	In	in	IN
cord-016523-pznw2ciu	191	2	addition	addition	NN
cord-016523-pznw2ciu	191	3	,	,	,
cord-016523-pznw2ciu	191	4	RIP3	RIP3	NNP
cord-016523-pznw2ciu	191	5	(	(	-LRB-
cord-016523-pznw2ciu	191	6	RIPK3	RIPK3	NNP
cord-016523-pznw2ciu	191	7	,	,	,
cord-016523-pznw2ciu	191	8	a	a	DT
cord-016523-pznw2ciu	191	9	member	member	NN
cord-016523-pznw2ciu	191	10	of	of	IN
cord-016523-pznw2ciu	191	11	the	the	DT
cord-016523-pznw2ciu	191	12	RIP	RIP	NNP
cord-016523-pznw2ciu	191	13	kinase	kinase	NNP
cord-016523-pznw2ciu	191	14	family	family	NN
cord-016523-pznw2ciu	191	15	)	)	-RRB-
cord-016523-pznw2ciu	191	16	is	be	VBZ
cord-016523-pznw2ciu	191	17	an	an	DT
cord-016523-pznw2ciu	191	18	indispensable	indispensable	JJ
cord-016523-pznw2ciu	191	19	factor	factor	NN
cord-016523-pznw2ciu	191	20	for	for	IN
cord-016523-pznw2ciu	191	21	the	the	DT
cord-016523-pznw2ciu	191	22	induction	induction	NN
cord-016523-pznw2ciu	191	23	of	of	IN
cord-016523-pznw2ciu	191	24	the	the	DT
cord-016523-pznw2ciu	191	25	necrotic	necrotic	JJ
cord-016523-pznw2ciu	191	26	signaling	signal	VBG
cord-016523-pznw2ciu	191	27	pathway	pathway	NN
cord-016523-pznw2ciu	191	28	[	[	-LRB-
cord-016523-pznw2ciu	191	29	78	78	CD
cord-016523-pznw2ciu	191	30	-80	-80	NNP
cord-016523-pznw2ciu	191	31	]	]	-RRB-
cord-016523-pznw2ciu	191	32	.	.	.
cord-016523-pznw2ciu	192	1	A	a	DT
cord-016523-pznw2ciu	192	2	growing	grow	VBG
cord-016523-pznw2ciu	192	3	body	body	NN
cord-016523-pznw2ciu	192	4	of	of	IN
cord-016523-pznw2ciu	192	5	evidence	evidence	NN
cord-016523-pznw2ciu	192	6	supports	support	VBZ
cord-016523-pznw2ciu	192	7	the	the	DT
cord-016523-pznw2ciu	192	8	existence	existence	NN
cord-016523-pznw2ciu	192	9	of	of	IN
cord-016523-pznw2ciu	192	10	necroptosis	necroptosis	NNP
cord-016523-pznw2ciu	192	11	(	(	-LRB-
cord-016523-pznw2ciu	192	12	programmed	program	VBN
cord-016523-pznw2ciu	192	13	necrosis	necrosis	NN
cord-016523-pznw2ciu	192	14	)	)	-RRB-
cord-016523-pznw2ciu	192	15	.	.	.
cord-016523-pznw2ciu	193	1	In	in	IN
cord-016523-pznw2ciu	193	2	addition	addition	NN
cord-016523-pznw2ciu	193	3	,	,	,
cord-016523-pznw2ciu	193	4	identifi	identifi	NNP
cord-016523-pznw2ciu	193	5	cation	cation	NNP
cord-016523-pznw2ciu	193	6	of	of	IN
cord-016523-pznw2ciu	193	7	necrostatin	necrostatin	NNP
cord-016523-pznw2ciu	193	8	,	,	,
cord-016523-pznw2ciu	193	9	a	a	DT
cord-016523-pznw2ciu	193	10	chemical	chemical	JJ
cord-016523-pznw2ciu	193	11	inhibitor	inhibitor	NN
cord-016523-pznw2ciu	193	12	of	of	IN
cord-016523-pznw2ciu	193	13	necroptosis	necroptosis	NNP
cord-016523-pznw2ciu	193	14	[	[	-LRB-
cord-016523-pznw2ciu	193	15	130	130	CD
cord-016523-pznw2ciu	193	16	]	]	-RRB-
cord-016523-pznw2ciu	193	17	,	,	,
cord-016523-pznw2ciu	193	18	which	which	WDT
cord-016523-pznw2ciu	193	19	specifi	specifi	NNP
cord-016523-pznw2ciu	193	20	cally	cally	RB
cord-016523-pznw2ciu	193	21	inhibits	inhibit	VBZ
cord-016523-pznw2ciu	193	22	RIP1	rip1	NN
cord-016523-pznw2ciu	193	23	kinase	kinase	NN
cord-016523-pznw2ciu	193	24	activity	activity	NN
cord-016523-pznw2ciu	193	25	[	[	-LRB-
cord-016523-pznw2ciu	193	26	131	131	CD
cord-016523-pznw2ciu	193	27	]	]	-RRB-
cord-016523-pznw2ciu	193	28	,	,	,
cord-016523-pznw2ciu	193	29	has	have	VBZ
cord-016523-pznw2ciu	193	30	accelerated	accelerate	VBN
cord-016523-pznw2ciu	193	31	the	the	DT
cord-016523-pznw2ciu	193	32	pace	pace	NN
cord-016523-pznw2ciu	193	33	of	of	IN
cord-016523-pznw2ciu	193	34	discovery	discovery	NN
cord-016523-pznw2ciu	193	35	in	in	IN
cord-016523-pznw2ciu	193	36	this	this	DT
cord-016523-pznw2ciu	193	37	fi	fi	NN
cord-016523-pznw2ciu	193	38	eld	eld	NN
cord-016523-pznw2ciu	193	39	of	of	IN
cord-016523-pznw2ciu	193	40	cell	cell	NN
cord-016523-pznw2ciu	193	41	death	death	NN
cord-016523-pznw2ciu	193	42	.	.	.
cord-016523-pznw2ciu	194	1	Interplays	interplay	NNS
cord-016523-pznw2ciu	194	2	exist	exist	VBP
cord-016523-pznw2ciu	194	3	between	between	IN
cord-016523-pznw2ciu	194	4	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	194	5	and	and	CC
cord-016523-pznw2ciu	194	6	necroptosis	necroptosis	NN
cord-016523-pznw2ciu	194	7	;	;	:
cord-016523-pznw2ciu	194	8	for	for	IN
cord-016523-pznw2ciu	194	9	instance	instance	NN
cord-016523-pznw2ciu	194	10	,	,	,
cord-016523-pznw2ciu	194	11	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	194	12	,	,	,
cord-016523-pznw2ciu	194	13	a	a	DT
cord-016523-pznw2ciu	194	14	potent	potent	JJ
cord-016523-pznw2ciu	194	15	inhibitor	inhibitor	NN
cord-016523-pznw2ciu	194	16	of	of	IN
cord-016523-pznw2ciu	194	17	necroptosis	necroptosis	NN
cord-016523-pznw2ciu	194	18	for	for	IN
cord-016523-pznw2ciu	194	19	both	both	DT
cord-016523-pznw2ciu	194	20	CD95	CD95	NNP
cord-016523-pznw2ciu	194	21	and	and	CC
cord-016523-pznw2ciu	195	1	TNFR1	TNFR1	NNP
cord-016523-pznw2ciu	195	2	[	[	-LRB-
cord-016523-pznw2ciu	195	3	132	132	CD
cord-016523-pznw2ciu	195	4	]	]	-RRB-
cord-016523-pznw2ciu	195	5	,	,	,
cord-016523-pznw2ciu	195	6	plays	play	VBZ
cord-016523-pznw2ciu	195	7	a	a	DT
cord-016523-pznw2ciu	195	8	critical	critical	JJ
cord-016523-pznw2ciu	195	9	role	role	NN
cord-016523-pznw2ciu	195	10	in	in	IN
cord-016523-pznw2ciu	195	11	necroptosis	necroptosis	NNP
cord-016523-pznw2ciu	195	12	by	by	IN
cord-016523-pznw2ciu	195	13	its	-PRON-	PRP$
cord-016523-pznw2ciu	195	14	ability	ability	NN
cord-016523-pznw2ciu	195	15	to	to	TO
cord-016523-pznw2ciu	195	16	process	process	VB
cord-016523-pznw2ciu	195	17	and	and	CC
cord-016523-pznw2ciu	195	18	inactivate	inactivate	VB
cord-016523-pznw2ciu	195	19	RIP1	RIP1	NNP
cord-016523-pznw2ciu	195	20	and	and	CC
cord-016523-pznw2ciu	195	21	RIP3	RIP3	NNPS
cord-016523-pznw2ciu	195	22	[	[	-LRB-
cord-016523-pznw2ciu	195	23	133	133	CD
cord-016523-pznw2ciu	195	24	,	,	,
cord-016523-pznw2ciu	195	25	134	134	CD
cord-016523-pznw2ciu	195	26	]	]	-RRB-
cord-016523-pznw2ciu	195	27	.	.	.
cord-016523-pznw2ciu	196	1	At	at	IN
cord-016523-pznw2ciu	196	2	least	least	JJS
cord-016523-pznw2ciu	196	3	for	for	IN
cord-016523-pznw2ciu	197	1	TNF	TNF	NNP
cord-016523-pznw2ciu	197	2	signaling	signaling	NN
cord-016523-pznw2ciu	197	3	,	,	,
cord-016523-pznw2ciu	197	4	the	the	DT
cord-016523-pznw2ciu	197	5	necrotic	necrotic	JJ
cord-016523-pznw2ciu	197	6	signal	signal	NN
cord-016523-pznw2ciu	197	7	relies	rely	VBZ
cord-016523-pznw2ciu	197	8	on	on	IN
cord-016523-pznw2ciu	197	9	the	the	DT
cord-016523-pznw2ciu	197	10	activity	activity	NN
cord-016523-pznw2ciu	197	11	of	of	IN
cord-016523-pznw2ciu	197	12	CYLD	CYLD	NNP
cord-016523-pznw2ciu	197	13	,	,	,
cord-016523-pznw2ciu	197	14	a	a	DT
cord-016523-pznw2ciu	197	15	deubiquitinat	deubiquitinat	NNP
cord-016523-pznw2ciu	197	16	-	-	HYPH
cord-016523-pznw2ciu	197	17	ing	e	VBG
cord-016523-pznw2ciu	197	18	enzyme	enzyme	NN
cord-016523-pznw2ciu	197	19	that	that	WDT
cord-016523-pznw2ciu	197	20	is	be	VBZ
cord-016523-pznw2ciu	197	21	also	also	RB
cord-016523-pznw2ciu	197	22	cleaved	cleave	VBN
cord-016523-pznw2ciu	197	23	and	and	CC
cord-016523-pznw2ciu	197	24	inactivated	inactivate	VBN
cord-016523-pznw2ciu	197	25	by	by	IN
cord-016523-pznw2ciu	197	26	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	197	27	[	[	-LRB-
cord-016523-pznw2ciu	197	28	135	135	CD
cord-016523-pznw2ciu	197	29	]	]	-RRB-
cord-016523-pznw2ciu	197	30	.	.	.
cord-016523-pznw2ciu	198	1	Overall	overall	RB
cord-016523-pznw2ciu	198	2	,	,	,
cord-016523-pznw2ciu	198	3	these	these	DT
cord-016523-pznw2ciu	198	4	fi	fi	NN
cord-016523-pznw2ciu	198	5	ndings	nding	NNS
cord-016523-pznw2ciu	198	6	suggest	suggest	VBP
cord-016523-pznw2ciu	198	7	that	that	IN
cord-016523-pznw2ciu	198	8	the	the	DT
cord-016523-pznw2ciu	198	9	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	198	10	machinery	machinery	NN
cord-016523-pznw2ciu	198	11	controls	control	VBZ
cord-016523-pznw2ciu	198	12	the	the	DT
cord-016523-pznw2ciu	198	13	necrotic	necrotic	JJ
cord-016523-pznw2ciu	198	14	one	one	CD
cord-016523-pznw2ciu	198	15	.	.	.
cord-016523-pznw2ciu	199	1	This	this	DT
cord-016523-pznw2ciu	199	2	concept	concept	NN
cord-016523-pznw2ciu	199	3	has	have	VBZ
cord-016523-pznw2ciu	199	4	been	be	VBN
cord-016523-pznw2ciu	199	5	recently	recently	RB
cord-016523-pznw2ciu	199	6	established	establish	VBN
cord-016523-pznw2ciu	199	7	in	in	IN
cord-016523-pznw2ciu	199	8	vivo	vivo	NN
cord-016523-pznw2ciu	199	9	by	by	IN
cord-016523-pznw2ciu	199	10	double	double	JJ
cord-016523-pznw2ciu	199	11	-	-	HYPH
cord-016523-pznw2ciu	199	12	KO	ko	NN
cord-016523-pznw2ciu	199	13	experiments	experiment	NNS
cord-016523-pznw2ciu	199	14	[	[	-LRB-
cord-016523-pznw2ciu	199	15	44	44	CD
cord-016523-pznw2ciu	199	16	-46	-46	NNP
cord-016523-pznw2ciu	199	17	,	,	,
cord-016523-pznw2ciu	199	18	136	136	CD
cord-016523-pznw2ciu	199	19	]	]	-RRB-
cord-016523-pznw2ciu	199	20	.	.	.
cord-016523-pznw2ciu	200	1	The	the	DT
cord-016523-pznw2ciu	200	2	KO	KO	NNP
cord-016523-pznw2ciu	200	3	of	of	IN
cord-016523-pznw2ciu	200	4	FADD	FADD	NNP
cord-016523-pznw2ciu	200	5	or	or	CC
cord-016523-pznw2ciu	200	6	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	200	7	is	be	VBZ
cord-016523-pznw2ciu	200	8	deleterious	deleterious	JJ
cord-016523-pznw2ciu	200	9	in	in	IN
cord-016523-pznw2ciu	200	10	mice	mouse	NNS
cord-016523-pznw2ciu	200	11	mainly	mainly	RB
cord-016523-pznw2ciu	200	12	by	by	IN
cord-016523-pznw2ciu	200	13	the	the	DT
cord-016523-pznw2ciu	200	14	fact	fact	NN
cord-016523-pznw2ciu	200	15	that	that	IN
cord-016523-pznw2ciu	200	16	these	these	DT
cord-016523-pznw2ciu	200	17	two	two	CD
cord-016523-pznw2ciu	200	18	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	200	19	factors	factor	NNS
cord-016523-pznw2ciu	200	20	are	be	VBP
cord-016523-pznw2ciu	200	21	benefi	benefi	NNP
cord-016523-pznw2ciu	200	22	cial	cial	NN
cord-016523-pznw2ciu	200	23	in	in	IN
cord-016523-pznw2ciu	200	24	inhibiting	inhibit	VBG
cord-016523-pznw2ciu	200	25	a	a	DT
cord-016523-pznw2ciu	200	26	RIP1-/RIP3-dependent	rip1-/rip3-dependent	NN
cord-016523-pznw2ciu	200	27	necrotic	necrotic	JJ
cord-016523-pznw2ciu	200	28	signal	signal	NN
cord-016523-pznw2ciu	200	29	;	;	:
cord-016523-pznw2ciu	200	30	thus	thus	RB
cord-016523-pznw2ciu	200	31	,	,	,
cord-016523-pznw2ciu	200	32	their	-PRON-	PRP$
cord-016523-pznw2ciu	200	33	loss	loss	NN
cord-016523-pznw2ciu	200	34	unleashes	unleash	VBZ
cord-016523-pznw2ciu	200	35	the	the	DT
cord-016523-pznw2ciu	200	36	necroptotic	necroptotic	JJ
cord-016523-pznw2ciu	200	37	program	program	NN
cord-016523-pznw2ciu	200	38	and	and	CC
cord-016523-pznw2ciu	200	39	leads	lead	VBZ
cord-016523-pznw2ciu	200	40	to	to	IN
cord-016523-pznw2ciu	200	41	embryonic	embryonic	JJ
cord-016523-pznw2ciu	200	42	lethality	lethality	NN
cord-016523-pznw2ciu	200	43	.	.	.
cord-016523-pznw2ciu	201	1	Yet	yet	RB
cord-016523-pznw2ciu	201	2	,	,	,
cord-016523-pznw2ciu	201	3	most	most	JJS
cord-016523-pznw2ciu	201	4	studies	study	NNS
cord-016523-pznw2ciu	201	5	on	on	IN
cord-016523-pznw2ciu	201	6	necroptosis	necroptosis	NNP
cord-016523-pznw2ciu	201	7	have	have	VBP
cord-016523-pznw2ciu	201	8	focused	focus	VBN
cord-016523-pznw2ciu	201	9	on	on	IN
cord-016523-pznw2ciu	201	10	the	the	DT
cord-016523-pznw2ciu	201	11	TNF	TNF	NNP
cord-016523-pznw2ciu	201	12	signaling	signal	VBG
cord-016523-pznw2ciu	201	13	pathway	pathway	NN
cord-016523-pznw2ciu	201	14	,	,	,
cord-016523-pznw2ciu	201	15	whereas	whereas	IN
cord-016523-pznw2ciu	201	16	the	the	DT
cord-016523-pznw2ciu	201	17	mechanism	mechanism	NN
cord-016523-pznw2ciu	201	18	by	by	IN
cord-016523-pznw2ciu	201	19	which	which	WDT
cord-016523-pznw2ciu	201	20	CD95	CD95	NNP
cord-016523-pznw2ciu	201	21	can	can	MD
cord-016523-pznw2ciu	201	22	elicit	elicit	VB
cord-016523-pznw2ciu	201	23	this	this	DT
cord-016523-pznw2ciu	201	24	cell	cell	NN
cord-016523-pznw2ciu	201	25	death	death	NN
cord-016523-pznw2ciu	201	26	pathway	pathway	NN
cord-016523-pznw2ciu	201	27	,	,	,
cord-016523-pznw2ciu	201	28	and	and	CC
cord-016523-pznw2ciu	201	29	how	how	WRB
cord-016523-pznw2ciu	201	30	the	the	DT
cord-016523-pznw2ciu	201	31	switch	switch	NN
cord-016523-pznw2ciu	201	32	in	in	IN
cord-016523-pznw2ciu	201	33	this	this	DT
cord-016523-pznw2ciu	201	34	receptor	receptor	NN
cord-016523-pznw2ciu	201	35	occurs	occur	VBZ
cord-016523-pznw2ciu	201	36	between	between	IN
cord-016523-pznw2ciu	201	37	non	non	JJ
cord-016523-pznw2ciu	201	38	-	-	JJ
cord-016523-pznw2ciu	201	39	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	201	40	,	,	,
cord-016523-pznw2ciu	201	41	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	201	42	,	,	,
cord-016523-pznw2ciu	201	43	and	and	CC
cord-016523-pznw2ciu	201	44	necroptotic	necroptotic	JJ
cord-016523-pznw2ciu	201	45	signals	signal	NNS
cord-016523-pznw2ciu	201	46	remains	remain	VBZ
cord-016523-pznw2ciu	201	47	unclear	unclear	JJ
cord-016523-pznw2ciu	201	48	.	.	.
cord-016523-pznw2ciu	202	1	Importantly	importantly	RB
cord-016523-pznw2ciu	202	2	,	,	,
cord-016523-pznw2ciu	202	3	the	the	DT
cord-016523-pznw2ciu	202	4	impact	impact	NN
cord-016523-pznw2ciu	202	5	of	of	IN
cord-016523-pznw2ciu	202	6	each	each	DT
cord-016523-pznw2ciu	202	7	cell	cell	NN
cord-016523-pznw2ciu	202	8	death	death	NN
cord-016523-pznw2ciu	202	9	on	on	IN
cord-016523-pznw2ciu	202	10	antigen	antigen	NN
cord-016523-pznw2ciu	202	11	presentation	presentation	NN
cord-016523-pznw2ciu	202	12	,	,	,
cord-016523-pznw2ciu	202	13	and	and	CC
cord-016523-pznw2ciu	202	14	on	on	IN
cord-016523-pznw2ciu	202	15	the	the	DT
cord-016523-pznw2ciu	202	16	effi	effi	NNP
cord-016523-pznw2ciu	202	17	ciency	ciency	NNP
cord-016523-pznw2ciu	202	18	of	of	IN
cord-016523-pznw2ciu	202	19	immune	immune	JJ
cord-016523-pznw2ciu	202	20	response	response	NN
cord-016523-pznw2ciu	202	21	after	after	IN
cord-016523-pznw2ciu	202	22	elimination	elimination	NN
cord-016523-pznw2ciu	202	23	of	of	IN
cord-016523-pznw2ciu	202	24	infected	infected	JJ
cord-016523-pznw2ciu	202	25	or	or	CC
cord-016523-pznw2ciu	202	26	transformed	transform	VBN
cord-016523-pznw2ciu	202	27	cells	cell	NNS
cord-016523-pznw2ciu	202	28	,	,	,
cord-016523-pznw2ciu	202	29	remains	remain	VBZ
cord-016523-pznw2ciu	202	30	unclear	unclear	JJ
cord-016523-pznw2ciu	202	31	.	.	.
cord-016523-pznw2ciu	203	1	Oncogenic	oncogenic	JJ
cord-016523-pznw2ciu	203	2	Cytokine	cytokine	NN
cord-016523-pznw2ciu	203	3	?	?	.
cord-016523-pznw2ciu	204	1	The	the	DT
cord-016523-pznw2ciu	204	2	transmembrane	transmembrane	NN
cord-016523-pznw2ciu	204	3	CD95L	cd95l	NN
cord-016523-pznw2ciu	205	1	(	(	-LRB-
cord-016523-pznw2ciu	205	2	CD178	CD178	NNP
cord-016523-pznw2ciu	205	3	/	/	SYM
cord-016523-pznw2ciu	205	4	FasL	FasL	NNP
cord-016523-pznw2ciu	205	5	)	)	-RRB-
cord-016523-pznw2ciu	205	6	is	be	VBZ
cord-016523-pznw2ciu	205	7	present	present	JJ
cord-016523-pznw2ciu	205	8	at	at	IN
cord-016523-pznw2ciu	205	9	the	the	DT
cord-016523-pznw2ciu	205	10	surface	surface	NN
cord-016523-pznw2ciu	205	11	of	of	IN
cord-016523-pznw2ciu	205	12	activated	activate	VBN
cord-016523-pznw2ciu	205	13	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	205	14	[	[	-LRB-
cord-016523-pznw2ciu	205	15	64	64	CD
cord-016523-pznw2ciu	205	16	]	]	-RRB-
cord-016523-pznw2ciu	205	17	and	and	CC
cord-016523-pznw2ciu	205	18	NK	NK	NNP
cord-016523-pznw2ciu	205	19	cells	cell	NNS
cord-016523-pznw2ciu	205	20	[	[	-LRB-
cord-016523-pznw2ciu	205	21	137	137	CD
cord-016523-pznw2ciu	205	22	]	]	-RRB-
cord-016523-pznw2ciu	206	1	where	where	WRB
cord-016523-pznw2ciu	206	2	it	-PRON-	PRP
cord-016523-pznw2ciu	206	3	orchestrates	orchestrate	VBZ
cord-016523-pznw2ciu	206	4	the	the	DT
cord-016523-pznw2ciu	206	5	elimination	elimination	NN
cord-016523-pznw2ciu	206	6	of	of	IN
cord-016523-pznw2ciu	206	7	transformed	transform	VBN
cord-016523-pznw2ciu	206	8	and	and	CC
cord-016523-pznw2ciu	206	9	infected	infected	JJ
cord-016523-pznw2ciu	206	10	cells	cell	NNS
cord-016523-pznw2ciu	206	11	.	.	.
cord-016523-pznw2ciu	207	1	In	in	IN
cord-016523-pznw2ciu	207	2	addition	addition	NN
cord-016523-pznw2ciu	207	3	,	,	,
cord-016523-pznw2ciu	207	4	CD95L	CD95L	NNP
cord-016523-pznw2ciu	207	5	is	be	VBZ
cord-016523-pznw2ciu	207	6	expressed	express	VBN
cord-016523-pznw2ciu	207	7	on	on	IN
cord-016523-pznw2ciu	207	8	the	the	DT
cord-016523-pznw2ciu	207	9	surface	surface	NN
cord-016523-pznw2ciu	207	10	of	of	IN
cord-016523-pznw2ciu	207	11	neurons	neuron	NNS
cord-016523-pznw2ciu	207	12	[	[	-LRB-
cord-016523-pznw2ciu	207	13	138	138	CD
cord-016523-pznw2ciu	207	14	]	]	-RRB-
cord-016523-pznw2ciu	207	15	,	,	,
cord-016523-pznw2ciu	207	16	corneal	corneal	JJ
cord-016523-pznw2ciu	207	17	epithelia	epithelium	NNS
cord-016523-pznw2ciu	207	18	and	and	CC
cord-016523-pznw2ciu	207	19	endothelia	endothelia	NNP
cord-016523-pznw2ciu	207	20	[	[	-LRB-
cord-016523-pznw2ciu	207	21	58	58	CD
cord-016523-pznw2ciu	207	22	,	,	,
cord-016523-pznw2ciu	207	23	139	139	CD
cord-016523-pznw2ciu	207	24	]	]	-RRB-
cord-016523-pznw2ciu	207	25	,	,	,
cord-016523-pznw2ciu	207	26	and	and	CC
cord-016523-pznw2ciu	207	27	sertoli	sertoli	JJ
cord-016523-pznw2ciu	207	28	cells	cell	NNS
cord-016523-pznw2ciu	207	29	[	[	-LRB-
cord-016523-pznw2ciu	207	30	59	59	CD
cord-016523-pznw2ciu	207	31	]	]	-RRB-
cord-016523-pznw2ciu	207	32	to	to	TO
cord-016523-pznw2ciu	207	33	prevent	prevent	VB
cord-016523-pznw2ciu	207	34	the	the	DT
cord-016523-pznw2ciu	207	35	infi	infi	NNP
cord-016523-pznw2ciu	207	36	ltration	ltration	NN
cord-016523-pznw2ciu	207	37	of	of	IN
cord-016523-pznw2ciu	207	38	immune	immune	JJ
cord-016523-pznw2ciu	207	39	cells	cell	NNS
cord-016523-pznw2ciu	207	40	and	and	CC
cord-016523-pznw2ciu	207	41	thus	thus	RB
cord-016523-pznw2ciu	207	42	to	to	TO
cord-016523-pznw2ciu	207	43	prohibit	prohibit	VB
cord-016523-pznw2ciu	207	44	the	the	DT
cord-016523-pznw2ciu	207	45	spread	spread	NN
cord-016523-pznw2ciu	207	46	of	of	IN
cord-016523-pznw2ciu	207	47	infl	infl	NN
cord-016523-pznw2ciu	207	48	ammation	ammation	NN
cord-016523-pznw2ciu	207	49	in	in	IN
cord-016523-pznw2ciu	207	50	these	these	DT
cord-016523-pznw2ciu	207	51	sensitive	sensitive	JJ
cord-016523-pznw2ciu	207	52	organs	organ	NNS
cord-016523-pznw2ciu	207	53	(	(	-LRB-
cord-016523-pznw2ciu	207	54	i.e.	i.e.	FW
cord-016523-pznw2ciu	207	55	,	,	,
cord-016523-pznw2ciu	207	56	brain	brain	NN
cord-016523-pznw2ciu	207	57	,	,	,
cord-016523-pznw2ciu	207	58	eyes	eye	NNS
cord-016523-pznw2ciu	207	59	,	,	,
cord-016523-pznw2ciu	207	60	and	and	CC
cord-016523-pznw2ciu	207	61	testis	testis	NN
cord-016523-pznw2ciu	207	62	,	,	,
cord-016523-pznw2ciu	207	63	respectively	respectively	RB
cord-016523-pznw2ciu	207	64	)	)	-RRB-
cord-016523-pznw2ciu	207	65	,	,	,
cord-016523-pznw2ciu	207	66	commonly	commonly	RB
cord-016523-pznw2ciu	207	67	called	call	VBN
cord-016523-pznw2ciu	207	68	"	"	``
cord-016523-pznw2ciu	207	69	immune	immune	NN
cord-016523-pznw2ciu	207	70	-	-	HYPH
cord-016523-pznw2ciu	207	71	privileged	privileged	JJ
cord-016523-pznw2ciu	207	72	"	"	''
cord-016523-pznw2ciu	207	73	sites	site	NNS
cord-016523-pznw2ciu	207	74	.	.	.
cord-016523-pznw2ciu	208	1	The	the	DT
cord-016523-pznw2ciu	208	2	description	description	NN
cord-016523-pznw2ciu	208	3	of	of	IN
cord-016523-pznw2ciu	208	4	physiological	physiological	JJ
cord-016523-pznw2ciu	208	5	immune	immune	JJ
cord-016523-pznw2ciu	208	6	privilege	privilege	NN
cord-016523-pznw2ciu	208	7	was	be	VBD
cord-016523-pznw2ciu	208	8	followed	follow	VBN
cord-016523-pznw2ciu	208	9	by	by	IN
cord-016523-pznw2ciu	208	10	tumor	tumor	NN
cord-016523-pznw2ciu	208	11	-	-	HYPH
cord-016523-pznw2ciu	208	12	mediated	mediate	VBN
cord-016523-pznw2ciu	208	13	immune	immune	JJ
cord-016523-pznw2ciu	208	14	privilege	privilege	NN
cord-016523-pznw2ciu	208	15	,	,	,
cord-016523-pznw2ciu	208	16	since	since	IN
cord-016523-pznw2ciu	208	17	two	two	CD
cord-016523-pznw2ciu	208	18	groups	group	NNS
cord-016523-pznw2ciu	208	19	reported	report	VBD
cord-016523-pznw2ciu	208	20	that	that	IN
cord-016523-pznw2ciu	208	21	the	the	DT
cord-016523-pznw2ciu	208	22	ectopic	ectopic	JJ
cord-016523-pznw2ciu	208	23	expression	expression	NN
cord-016523-pznw2ciu	208	24	of	of	IN
cord-016523-pznw2ciu	208	25	CD95L	cd95l	NN
cord-016523-pznw2ciu	208	26	by	by	IN
cord-016523-pznw2ciu	208	27	malignant	malignant	JJ
cord-016523-pznw2ciu	208	28	cells	cell	NNS
cord-016523-pznw2ciu	208	29	participated	participate	VBN
cord-016523-pznw2ciu	208	30	in	in	IN
cord-016523-pznw2ciu	208	31	the	the	DT
cord-016523-pznw2ciu	208	32	elimination	elimination	NN
cord-016523-pznw2ciu	208	33	of	of	IN
cord-016523-pznw2ciu	208	34	infi	infi	NNP
cord-016523-pznw2ciu	208	35	ltrating	ltrating	NNP
cord-016523-pznw2ciu	208	36	T	T	NNP
cord-016523-pznw2ciu	208	37	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	208	38	and	and	CC
cord-016523-pznw2ciu	208	39	thus	thus	RB
cord-016523-pznw2ciu	208	40	could	could	MD
cord-016523-pznw2ciu	208	41	play	play	VB
cord-016523-pznw2ciu	208	42	a	a	DT
cord-016523-pznw2ciu	208	43	role	role	NN
cord-016523-pznw2ciu	208	44	in	in	IN
cord-016523-pznw2ciu	208	45	the	the	DT
cord-016523-pznw2ciu	208	46	establishment	establishment	NN
cord-016523-pznw2ciu	208	47	of	of	IN
cord-016523-pznw2ciu	208	48	a	a	DT
cord-016523-pznw2ciu	208	49	tumor	tumor	NN
cord-016523-pznw2ciu	208	50	site	site	NN
cord-016523-pznw2ciu	208	51	whose	whose	WP$
cord-016523-pznw2ciu	208	52	access	access	NN
cord-016523-pznw2ciu	208	53	was	be	VBD
cord-016523-pznw2ciu	208	54	denied	deny	VBN
cord-016523-pznw2ciu	208	55	to	to	IN
cord-016523-pznw2ciu	208	56	immune	immune	JJ
cord-016523-pznw2ciu	208	57	cells	cell	NNS
cord-016523-pznw2ciu	208	58	[	[	-LRB-
cord-016523-pznw2ciu	208	59	140	140	CD
cord-016523-pznw2ciu	208	60	,	,	,
cord-016523-pznw2ciu	208	61	141	141	CD
cord-016523-pznw2ciu	208	62	]	]	-RRB-
cord-016523-pznw2ciu	208	63	.	.	.
cord-016523-pznw2ciu	209	1	However	however	RB
cord-016523-pznw2ciu	209	2	,	,	,
cord-016523-pznw2ciu	209	3	these	these	DT
cord-016523-pznw2ciu	209	4	observations	observation	NNS
cord-016523-pznw2ciu	209	5	are	be	VBP
cord-016523-pznw2ciu	209	6	controversial	controversial	JJ
cord-016523-pznw2ciu	209	7	since	since	IN
cord-016523-pznw2ciu	209	8	ectopic	ectopic	JJ
cord-016523-pznw2ciu	209	9	expression	expression	NN
cord-016523-pznw2ciu	209	10	of	of	IN
cord-016523-pznw2ciu	209	11	CD95L	cd95l	NN
cord-016523-pznw2ciu	209	12	in	in	IN
cord-016523-pznw2ciu	209	13	allogenic	allogenic	JJ
cord-016523-pznw2ciu	209	14	transplant	transplant	NN
cord-016523-pznw2ciu	209	15	of	of	IN
cord-016523-pznw2ciu	209	16	β	β	NN
cord-016523-pznw2ciu	209	17	-	-	HYPH
cord-016523-pznw2ciu	209	18	islets	islet	NNS
cord-016523-pznw2ciu	209	19	[	[	-LRB-
cord-016523-pznw2ciu	209	20	142	142	CD
cord-016523-pznw2ciu	209	21	,	,	,
cord-016523-pznw2ciu	209	22	143	143	CD
cord-016523-pznw2ciu	209	23	]	]	-RRB-
cord-016523-pznw2ciu	209	24	and	and	CC
cord-016523-pznw2ciu	209	25	in	in	IN
cord-016523-pznw2ciu	209	26	tumor	tumor	NN
cord-016523-pznw2ciu	209	27	cell	cell	NN
cord-016523-pznw2ciu	209	28	lines	line	NNS
cord-016523-pznw2ciu	209	29	[	[	-LRB-
cord-016523-pznw2ciu	209	30	144	144	CD
cord-016523-pznw2ciu	209	31	]	]	-RRB-
cord-016523-pznw2ciu	209	32	led	lead	VBD
cord-016523-pznw2ciu	209	33	to	to	IN
cord-016523-pznw2ciu	209	34	a	a	DT
cord-016523-pznw2ciu	209	35	more	more	RBR
cord-016523-pznw2ciu	209	36	rapid	rapid	JJ
cord-016523-pznw2ciu	209	37	elimination	elimination	NN
cord-016523-pznw2ciu	209	38	of	of	IN
cord-016523-pznw2ciu	209	39	these	these	DT
cord-016523-pznw2ciu	209	40	cells	cell	NNS
cord-016523-pznw2ciu	209	41	than	than	IN
cord-016523-pznw2ciu	209	42	control	control	NN
cord-016523-pznw2ciu	209	43	cells	cell	NNS
cord-016523-pznw2ciu	209	44	,	,	,
cord-016523-pznw2ciu	209	45	due	due	JJ
cord-016523-pznw2ciu	209	46	to	to	IN
cord-016523-pznw2ciu	209	47	increased	increase	VBN
cord-016523-pznw2ciu	209	48	infi	infi	NNP
cord-016523-pznw2ciu	209	49	ltration	ltration	NN
cord-016523-pznw2ciu	209	50	of	of	IN
cord-016523-pznw2ciu	209	51	neutrophils	neutrophil	NNS
cord-016523-pznw2ciu	209	52	and	and	CC
cord-016523-pznw2ciu	209	53	macrophages	macrophage	NNS
cord-016523-pznw2ciu	209	54	endowed	endow	VBN
cord-016523-pznw2ciu	209	55	with	with	IN
cord-016523-pznw2ciu	209	56	antitumor	antitumor	JJ
cord-016523-pznw2ciu	209	57	activity	activity	NN
cord-016523-pznw2ciu	209	58	.	.	.
cord-016523-pznw2ciu	210	1	Among	among	IN
cord-016523-pznw2ciu	210	2	the	the	DT
cord-016523-pznw2ciu	210	3	weapons	weapon	NNS
cord-016523-pznw2ciu	210	4	at	at	IN
cord-016523-pznw2ciu	210	5	the	the	DT
cord-016523-pznw2ciu	210	6	disposal	disposal	NN
cord-016523-pznw2ciu	210	7	of	of	IN
cord-016523-pznw2ciu	210	8	immune	immune	JJ
cord-016523-pznw2ciu	210	9	cells	cell	NNS
cord-016523-pznw2ciu	210	10	,	,	,
cord-016523-pznw2ciu	210	11	transmembrane	transmembrane	NNP
cord-016523-pznw2ciu	210	12	CD95L	cd95l	NN
cord-016523-pznw2ciu	210	13	contributes	contribute	VBZ
cord-016523-pznw2ciu	210	14	to	to	IN
cord-016523-pznw2ciu	210	15	the	the	DT
cord-016523-pznw2ciu	210	16	elimination	elimination	NN
cord-016523-pznw2ciu	210	17	of	of	IN
cord-016523-pznw2ciu	210	18	pre	pre	JJ
cord-016523-pznw2ciu	210	19	-	-	JJ
cord-016523-pznw2ciu	210	20	tumor	tumor	JJ
cord-016523-pznw2ciu	210	21	cells	cell	NNS
cord-016523-pznw2ciu	210	22	.	.	.
cord-016523-pznw2ciu	211	1	Therefore	therefore	RB
cord-016523-pznw2ciu	211	2	,	,	,
cord-016523-pznw2ciu	211	3	pretumor	pretumor	NN
cord-016523-pznw2ciu	211	4	cells	cell	NNS
cord-016523-pznw2ciu	211	5	that	that	WDT
cord-016523-pznw2ciu	211	6	escape	escape	VBP
cord-016523-pznw2ciu	211	7	the	the	DT
cord-016523-pznw2ciu	211	8	immunosurveillance	immunosurveillance	NN
cord-016523-pznw2ciu	211	9	will	will	MD
cord-016523-pznw2ciu	211	10	be	be	VB
cord-016523-pznw2ciu	211	11	shaped	shape	VBN
cord-016523-pznw2ciu	211	12	to	to	TO
cord-016523-pznw2ciu	211	13	develop	develop	VB
cord-016523-pznw2ciu	211	14	resistance	resistance	NN
cord-016523-pznw2ciu	211	15	to	to	IN
cord-016523-pznw2ciu	211	16	CD95	CD95	NNP
cord-016523-pznw2ciu	211	17	,	,	,
cord-016523-pznw2ciu	211	18	a	a	DT
cord-016523-pznw2ciu	211	19	process	process	NN
cord-016523-pznw2ciu	211	20	termed	term	VBN
cord-016523-pznw2ciu	211	21	immunoediting	immunoedite	VBG
cord-016523-pznw2ciu	211	22	[	[	-LRB-
cord-016523-pznw2ciu	211	23	145	145	CD
cord-016523-pznw2ciu	211	24	]	]	-RRB-
cord-016523-pznw2ciu	211	25	.	.	.
cord-016523-pznw2ciu	212	1	In	in	IN
cord-016523-pznw2ciu	212	2	other	other	JJ
cord-016523-pznw2ciu	212	3	words	word	NNS
cord-016523-pznw2ciu	212	4	,	,	,
cord-016523-pznw2ciu	212	5	imprinting	imprinting	NN
cord-016523-pznw2ciu	212	6	of	of	IN
cord-016523-pznw2ciu	212	7	the	the	DT
cord-016523-pznw2ciu	212	8	immune	immune	JJ
cord-016523-pznw2ciu	212	9	system	system	NN
cord-016523-pznw2ciu	212	10	on	on	IN
cord-016523-pznw2ciu	212	11	pretumor	pretumor	NN
cord-016523-pznw2ciu	212	12	cells	cell	NNS
cord-016523-pznw2ciu	212	13	will	will	MD
cord-016523-pznw2ciu	212	14	select	select	VB
cord-016523-pznw2ciu	212	15	malignant	malignant	JJ
cord-016523-pznw2ciu	212	16	cells	cell	NNS
cord-016523-pznw2ciu	212	17	with	with	IN
cord-016523-pznw2ciu	212	18	increased	increase	VBN
cord-016523-pznw2ciu	212	19	resistance	resistance	NN
cord-016523-pznw2ciu	212	20	towards	towards	IN
cord-016523-pznw2ciu	212	21	the	the	DT
cord-016523-pznw2ciu	212	22	CD95L	cd95l	NN
cord-016523-pznw2ciu	212	23	-	-	HYPH
cord-016523-pznw2ciu	212	24	induced	induce	VBN
cord-016523-pznw2ciu	212	25	signal	signal	NN
cord-016523-pznw2ciu	212	26	.	.	.
cord-016523-pznw2ciu	213	1	As	as	IN
cord-016523-pznw2ciu	213	2	previously	previously	RB
cord-016523-pznw2ciu	213	3	mentioned	mention	VBN
cord-016523-pznw2ciu	213	4	,	,	,
cord-016523-pznw2ciu	213	5	these	these	DT
cord-016523-pznw2ciu	213	6	alterations	alteration	NNS
cord-016523-pznw2ciu	213	7	of	of	IN
cord-016523-pznw2ciu	213	8	the	the	DT
cord-016523-pznw2ciu	213	9	CD95	CD95	NNP
cord-016523-pznw2ciu	213	10	signal	signal	NN
cord-016523-pznw2ciu	213	11	not	not	RB
cord-016523-pznw2ciu	213	12	only	only	RB
cord-016523-pznw2ciu	213	13	block	block	VB
cord-016523-pznw2ciu	213	14	the	the	DT
cord-016523-pznw2ciu	213	15	CD95-mediated	cd95-mediated	CD
cord-016523-pznw2ciu	213	16	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	213	17	signal	signal	NN
cord-016523-pznw2ciu	213	18	but	but	CC
cord-016523-pznw2ciu	213	19	also	also	RB
cord-016523-pznw2ciu	213	20	promote	promote	VB
cord-016523-pznw2ciu	213	21	the	the	DT
cord-016523-pznw2ciu	213	22	transmission	transmission	NN
cord-016523-pznw2ciu	213	23	of	of	IN
cord-016523-pznw2ciu	213	24	non	non	JJ
cord-016523-pznw2ciu	213	25	-	-	JJ
cord-016523-pznw2ciu	213	26	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	213	27	signals	signal	NNS
cord-016523-pznw2ciu	213	28	by	by	IN
cord-016523-pznw2ciu	213	29	CD95L	CD95L	NNS
cord-016523-pznw2ciu	213	30	,	,	,
cord-016523-pznw2ciu	213	31	which	which	WDT
cord-016523-pznw2ciu	213	32	may	may	MD
cord-016523-pznw2ciu	213	33	play	play	VB
cord-016523-pznw2ciu	213	34	a	a	DT
cord-016523-pznw2ciu	213	35	critical	critical	JJ
cord-016523-pznw2ciu	213	36	role	role	NN
cord-016523-pznw2ciu	213	37	in	in	IN
cord-016523-pznw2ciu	213	38	carcinogenesis	carcinogenesis	NN
cord-016523-pznw2ciu	213	39	[	[	-LRB-
cord-016523-pznw2ciu	213	40	106	106	CD
cord-016523-pznw2ciu	213	41	-108	-108	NN
cord-016523-pznw2ciu	213	42	,	,	,
cord-016523-pznw2ciu	213	43	146	146	CD
cord-016523-pznw2ciu	213	44	]	]	-RRB-
cord-016523-pznw2ciu	213	45	.	.	.
cord-016523-pznw2ciu	214	1	In	in	IN
cord-016523-pznw2ciu	214	2	agreement	agreement	NN
cord-016523-pznw2ciu	214	3	with	with	IN
cord-016523-pznw2ciu	214	4	this	this	DT
cord-016523-pznw2ciu	214	5	hypothesis	hypothesis	NN
cord-016523-pznw2ciu	214	6	,	,	,
cord-016523-pznw2ciu	214	7	a	a	DT
cord-016523-pznw2ciu	214	8	complete	complete	JJ
cord-016523-pznw2ciu	214	9	loss	loss	NN
cord-016523-pznw2ciu	214	10	of	of	IN
cord-016523-pznw2ciu	214	11	CD95	CD95	NNP
cord-016523-pznw2ciu	214	12	expression	expression	NN
cord-016523-pznw2ciu	214	13	is	be	VBZ
cord-016523-pznw2ciu	214	14	rarely	rarely	RB
cord-016523-pznw2ciu	214	15	observed	observe	VBN
cord-016523-pznw2ciu	214	16	in	in	IN
cord-016523-pznw2ciu	214	17	malignant	malignant	JJ
cord-016523-pznw2ciu	214	18	cells	cell	NNS
cord-016523-pznw2ciu	214	19	[	[	-LRB-
cord-016523-pznw2ciu	214	20	147	147	CD
cord-016523-pznw2ciu	214	21	]	]	-RRB-
cord-016523-pznw2ciu	214	22	.	.	.
cord-016523-pznw2ciu	215	1	Accumulating	accumulate	VBG
cord-016523-pznw2ciu	215	2	evidence	evidence	NN
cord-016523-pznw2ciu	215	3	indicates	indicate	VBZ
cord-016523-pznw2ciu	215	4	that	that	IN
cord-016523-pznw2ciu	215	5	the	the	DT
cord-016523-pznw2ciu	215	6	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	215	7	ligand	ligand	NN
cord-016523-pznw2ciu	215	8	CD95L	cd95l	NN
cord-016523-pznw2ciu	215	9	behaves	behave	VBZ
cord-016523-pznw2ciu	215	10	as	as	IN
cord-016523-pznw2ciu	215	11	a	a	DT
cord-016523-pznw2ciu	215	12	chemoattractant	chemoattractant	NN
cord-016523-pznw2ciu	215	13	for	for	IN
cord-016523-pznw2ciu	215	14	neutrophils	neutrophil	NNS
cord-016523-pznw2ciu	215	15	,	,	,
cord-016523-pznw2ciu	215	16	macrophages	macrophage	NNS
cord-016523-pznw2ciu	215	17	[	[	-LRB-
cord-016523-pznw2ciu	215	18	50	50	CD
cord-016523-pznw2ciu	215	19	,	,	,
cord-016523-pznw2ciu	215	20	143	143	CD
cord-016523-pznw2ciu	215	21	,	,	,
cord-016523-pznw2ciu	215	22	144	144	CD
cord-016523-pznw2ciu	215	23	]	]	-RRB-
cord-016523-pznw2ciu	215	24	,	,	,
cord-016523-pznw2ciu	215	25	T	t	NN
cord-016523-pznw2ciu	215	26	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	215	27	[	[	-LRB-
cord-016523-pznw2ciu	215	28	53	53	CD
cord-016523-pznw2ciu	215	29	]	]	-RRB-
cord-016523-pznw2ciu	215	30	,	,	,
cord-016523-pznw2ciu	215	31	and	and	CC
cord-016523-pznw2ciu	215	32	malignant	malignant	JJ
cord-016523-pznw2ciu	215	33	cells	cell	NNS
cord-016523-pznw2ciu	215	34	in	in	IN
cord-016523-pznw2ciu	215	35	which	which	WDT
cord-016523-pznw2ciu	215	36	the	the	DT
cord-016523-pznw2ciu	215	37	CD95-mediated	cd95-mediated	CD
cord-016523-pznw2ciu	215	38	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	215	39	signal	signal	NN
cord-016523-pznw2ciu	215	40	is	be	VBZ
cord-016523-pznw2ciu	215	41	nonproductive	nonproductive	JJ
cord-016523-pznw2ciu	215	42	[	[	-LRB-
cord-016523-pznw2ciu	215	43	108	108	CD
cord-016523-pznw2ciu	215	44	,	,	,
cord-016523-pznw2ciu	215	45	148	148	CD
cord-016523-pznw2ciu	215	46	]	]	-RRB-
cord-016523-pznw2ciu	215	47	.	.	.
cord-016523-pznw2ciu	216	1	Nonetheless	nonetheless	RB
cord-016523-pznw2ciu	216	2	,	,	,
cord-016523-pznw2ciu	216	3	the	the	DT
cord-016523-pznw2ciu	216	4	biological	biological	JJ
cord-016523-pznw2ciu	216	5	role	role	NN
cord-016523-pznw2ciu	216	6	of	of	IN
cord-016523-pznw2ciu	216	7	CD95L	CD95L	NNP
cord-016523-pznw2ciu	216	8	has	have	VBZ
cord-016523-pznw2ciu	216	9	to	to	TO
cord-016523-pznw2ciu	216	10	be	be	VB
cord-016523-pznw2ciu	216	11	clarifi	clarifi	VBN
cord-016523-pznw2ciu	216	12	ed	ed	NN
cord-016523-pznw2ciu	216	13	due	due	IN
cord-016523-pznw2ciu	216	14	to	to	IN
cord-016523-pznw2ciu	216	15	the	the	DT
cord-016523-pznw2ciu	216	16	fact	fact	NN
cord-016523-pznw2ciu	216	17	that	that	IN
cord-016523-pznw2ciu	216	18	pathophysiologically	pathophysiologically	RB
cord-016523-pznw2ciu	216	19	the	the	DT
cord-016523-pznw2ciu	216	20	ligand	ligand	NN
cord-016523-pznw2ciu	216	21	is	be	VBZ
cord-016523-pznw2ciu	216	22	present	present	JJ
cord-016523-pznw2ciu	216	23	in	in	IN
cord-016523-pznw2ciu	216	24	at	at	RB
cord-016523-pznw2ciu	216	25	least	least	RBS
cord-016523-pznw2ciu	216	26	two	two	CD
cord-016523-pznw2ciu	216	27	forms	form	NNS
cord-016523-pznw2ciu	216	28	with	with	IN
cord-016523-pznw2ciu	216	29	different	different	JJ
cord-016523-pznw2ciu	216	30	stoichiometries	stoichiometry	NNS
cord-016523-pznw2ciu	216	31	.	.	.
cord-016523-pznw2ciu	217	1	Indeed	indeed	RB
cord-016523-pznw2ciu	217	2	,	,	,
cord-016523-pznw2ciu	217	3	CD95L	CD95L	NNP
cord-016523-pznw2ciu	217	4	is	be	VBZ
cord-016523-pznw2ciu	217	5	a	a	DT
cord-016523-pznw2ciu	217	6	transmembrane	transmembrane	JJ
cord-016523-pznw2ciu	217	7	cytokine	cytokine	NN
cord-016523-pznw2ciu	217	8	whose	whose	WP$
cord-016523-pznw2ciu	217	9	ectodomain	ectodomain	NN
cord-016523-pznw2ciu	217	10	can	can	MD
cord-016523-pznw2ciu	217	11	be	be	VB
cord-016523-pznw2ciu	217	12	cleaved	cleave	VBN
cord-016523-pznw2ciu	217	13	by	by	IN
cord-016523-pznw2ciu	217	14	metalloproteases	metalloprotease	NNS
cord-016523-pznw2ciu	217	15	such	such	JJ
cord-016523-pznw2ciu	217	16	as	as	IN
cord-016523-pznw2ciu	217	17	MMP3	MMP3	NNP
cord-016523-pznw2ciu	217	18	[	[	-LRB-
cord-016523-pznw2ciu	217	19	149	149	CD
cord-016523-pznw2ciu	217	20	]	]	-RRB-
cord-016523-pznw2ciu	217	21	,	,	,
cord-016523-pznw2ciu	217	22	MMP7	MMP7	NNP
cord-016523-pznw2ciu	217	23	[	[	-LRB-
cord-016523-pznw2ciu	217	24	150	150	CD
cord-016523-pznw2ciu	217	25	]	]	-RRB-
cord-016523-pznw2ciu	217	26	,	,	,
cord-016523-pznw2ciu	217	27	MMP9	MMP9	NNP
cord-016523-pznw2ciu	217	28	[	[	-LRB-
cord-016523-pznw2ciu	217	29	151	151	CD
cord-016523-pznw2ciu	217	30	]	]	-RRB-
cord-016523-pznw2ciu	217	31	,	,	,
cord-016523-pznw2ciu	217	32	and	and	CC
cord-016523-pznw2ciu	217	33	ADAM-10	adam-10	CD
cord-016523-pznw2ciu	217	34	(	(	-LRB-
cord-016523-pznw2ciu	217	35	A	a	DT
cord-016523-pznw2ciu	217	36	disintegrin	disintegrin	NN
cord-016523-pznw2ciu	217	37	and	and	CC
cord-016523-pznw2ciu	217	38	metalloproteinase	metalloproteinase	NN
cord-016523-pznw2ciu	217	39	10	10	CD
cord-016523-pznw2ciu	217	40	)	)	-RRB-
cord-016523-pznw2ciu	217	41	[	[	-LRB-
cord-016523-pznw2ciu	217	42	152	152	CD
cord-016523-pznw2ciu	217	43	,	,	,
cord-016523-pznw2ciu	217	44	153	153	CD
cord-016523-pznw2ciu	217	45	]	]	-RRB-
cord-016523-pznw2ciu	217	46	and	and	CC
cord-016523-pznw2ciu	217	47	released	release	VBD
cord-016523-pznw2ciu	217	48	as	as	IN
cord-016523-pznw2ciu	217	49	a	a	DT
cord-016523-pznw2ciu	217	50	soluble	soluble	JJ
cord-016523-pznw2ciu	217	51	ligand	ligand	NN
cord-016523-pznw2ciu	217	52	in	in	IN
cord-016523-pznw2ciu	217	53	the	the	DT
cord-016523-pznw2ciu	217	54	bloodstream	bloodstream	NN
cord-016523-pznw2ciu	217	55	.	.	.
cord-016523-pznw2ciu	218	1	Based	base	VBN
cord-016523-pznw2ciu	218	2	on	on	IN
cord-016523-pznw2ciu	218	3	the	the	DT
cord-016523-pznw2ciu	218	4	data	datum	NNS
cord-016523-pznw2ciu	218	5	demonstrating	demonstrate	VBG
cord-016523-pznw2ciu	218	6	that	that	IN
cord-016523-pznw2ciu	218	7	a	a	DT
cord-016523-pznw2ciu	218	8	hexameric	hexameric	NN
cord-016523-pznw2ciu	218	9	CD95L	cd95l	NN
cord-016523-pznw2ciu	218	10	represents	represent	VBZ
cord-016523-pznw2ciu	218	11	the	the	DT
cord-016523-pznw2ciu	218	12	minimal	minimal	JJ
cord-016523-pznw2ciu	218	13	level	level	NN
cord-016523-pznw2ciu	218	14	of	of	IN
cord-016523-pznw2ciu	218	15	selfassociation	selfassociation	NN
cord-016523-pznw2ciu	218	16	required	require	VBN
cord-016523-pznw2ciu	218	17	to	to	TO
cord-016523-pznw2ciu	218	18	signal	signal	VB
cord-016523-pznw2ciu	218	19	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	218	20	[	[	-LRB-
cord-016523-pznw2ciu	218	21	154	154	CD
cord-016523-pznw2ciu	218	22	]	]	-RRB-
cord-016523-pznw2ciu	218	23	and	and	CC
cord-016523-pznw2ciu	218	24	that	that	DT
cord-016523-pznw2ciu	218	25	cleavage	cleavage	NN
cord-016523-pznw2ciu	218	26	by	by	IN
cord-016523-pznw2ciu	218	27	metalloproteases	metalloproteases	NNP
cord-016523-pznw2ciu	218	28	releases	release	VBZ
cord-016523-pznw2ciu	218	29	an	an	DT
cord-016523-pznw2ciu	218	30	homotrimeric	homotrimeric	JJ
cord-016523-pznw2ciu	218	31	ligand	ligand	NN
cord-016523-pznw2ciu	218	32	[	[	-LRB-
cord-016523-pznw2ciu	218	33	154	154	CD
cord-016523-pznw2ciu	218	34	,	,	,
cord-016523-pznw2ciu	218	35	155	155	CD
cord-016523-pznw2ciu	218	36	]	]	-RRB-
cord-016523-pznw2ciu	218	37	,	,	,
cord-016523-pznw2ciu	218	38	this	this	DT
cord-016523-pznw2ciu	218	39	soluble	soluble	JJ
cord-016523-pznw2ciu	218	40	ligand	ligand	NN
cord-016523-pznw2ciu	218	41	has	have	VBZ
cord-016523-pznw2ciu	218	42	long	long	RB
cord-016523-pznw2ciu	218	43	been	be	VBN
cord-016523-pznw2ciu	218	44	considered	consider	VBN
cord-016523-pznw2ciu	218	45	as	as	IN
cord-016523-pznw2ciu	218	46	an	an	DT
cord-016523-pznw2ciu	218	47	inert	inert	JJ
cord-016523-pznw2ciu	218	48	ligand	ligand	NN
cord-016523-pznw2ciu	218	49	competing	compete	VBG
cord-016523-pznw2ciu	218	50	with	with	IN
cord-016523-pznw2ciu	218	51	its	-PRON-	PRP$
cord-016523-pznw2ciu	218	52	membrane	membrane	NN
cord-016523-pznw2ciu	218	53	-	-	HYPH
cord-016523-pznw2ciu	218	54	bound	bind	VBN
cord-016523-pznw2ciu	218	55	counterpart	counterpart	NN
cord-016523-pznw2ciu	218	56	for	for	IN
cord-016523-pznw2ciu	218	57	CD95	CD95	NNP
cord-016523-pznw2ciu	218	58	binding	binding	NN
cord-016523-pznw2ciu	218	59	,	,	,
cord-016523-pznw2ciu	218	60	thus	thus	RB
cord-016523-pznw2ciu	218	61	acting	act	VBG
cord-016523-pznw2ciu	218	62	as	as	IN
cord-016523-pznw2ciu	218	63	an	an	DT
cord-016523-pznw2ciu	218	64	antagonist	antagonist	NN
cord-016523-pznw2ciu	218	65	of	of	IN
cord-016523-pznw2ciu	218	66	the	the	DT
cord-016523-pznw2ciu	218	67	death	death	NN
cord-016523-pznw2ciu	218	68	signal	signal	NN
cord-016523-pznw2ciu	218	69	[	[	-LRB-
cord-016523-pznw2ciu	218	70	155	155	CD
cord-016523-pznw2ciu	218	71	,	,	,
cord-016523-pznw2ciu	218	72	156	156	CD
cord-016523-pznw2ciu	218	73	]	]	-RRB-
cord-016523-pznw2ciu	218	74	.	.	.
cord-016523-pznw2ciu	219	1	It	-PRON-	PRP
cord-016523-pznw2ciu	219	2	has	have	VBZ
cord-016523-pznw2ciu	219	3	been	be	VBN
cord-016523-pznw2ciu	219	4	recently	recently	RB
cord-016523-pznw2ciu	219	5	demonstrated	demonstrate	VBN
cord-016523-pznw2ciu	219	6	that	that	IN
cord-016523-pznw2ciu	219	7	this	this	DT
cord-016523-pznw2ciu	219	8	metalloprotease	metalloprotease	NN
cord-016523-pznw2ciu	219	9	-	-	HYPH
cord-016523-pznw2ciu	219	10	cleaved	cleave	VBN
cord-016523-pznw2ciu	219	11	CD95L	cd95l	NN
cord-016523-pznw2ciu	219	12	(	(	-LRB-
cord-016523-pznw2ciu	219	13	cl	cl	NNP
cord-016523-pznw2ciu	219	14	-	-	HYPH
cord-016523-pznw2ciu	219	15	CD95L	CD95L	NNP
cord-016523-pznw2ciu	219	16	)	)	-RRB-
cord-016523-pznw2ciu	219	17	actively	actively	RB
cord-016523-pznw2ciu	219	18	participates	participate	VBZ
cord-016523-pznw2ciu	219	19	in	in	IN
cord-016523-pznw2ciu	219	20	the	the	DT
cord-016523-pznw2ciu	219	21	aggravation	aggravation	NN
cord-016523-pznw2ciu	219	22	of	of	IN
cord-016523-pznw2ciu	219	23	infl	infl	NNP
cord-016523-pznw2ciu	219	24	ammation	ammation	NN
cord-016523-pznw2ciu	219	25	and	and	CC
cord-016523-pznw2ciu	219	26	autoimmunity	autoimmunity	NN
cord-016523-pznw2ciu	219	27	in	in	IN
cord-016523-pznw2ciu	219	28	patients	patient	NNS
cord-016523-pznw2ciu	219	29	affected	affect	VBN
cord-016523-pznw2ciu	219	30	by	by	IN
cord-016523-pznw2ciu	219	31	systemic	systemic	JJ
cord-016523-pznw2ciu	219	32	lupus	lupus	NN
cord-016523-pznw2ciu	219	33	erythematosus	erythematosus	NN
cord-016523-pznw2ciu	219	34	(	(	-LRB-
cord-016523-pznw2ciu	219	35	SLE	SLE	NNP
cord-016523-pznw2ciu	219	36	)	)	-RRB-
cord-016523-pznw2ciu	219	37	by	by	IN
cord-016523-pznw2ciu	219	38	inducing	induce	VBG
cord-016523-pznw2ciu	219	39	the	the	DT
cord-016523-pznw2ciu	219	40	non	non	JJ
cord-016523-pznw2ciu	219	41	-	-	JJ
cord-016523-pznw2ciu	219	42	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	219	43	NF	nf	NN
cord-016523-pznw2ciu	219	44	-	-	HYPH
cord-016523-pznw2ciu	219	45	κB	κB	NNP
cord-016523-pznw2ciu	219	46	and	and	CC
cord-016523-pznw2ciu	219	47	PI3	PI3	NNP
cord-016523-pznw2ciu	219	48	K	K	NNP
cord-016523-pznw2ciu	219	49	[	[	-LRB-
cord-016523-pznw2ciu	219	50	51	51	CD
cord-016523-pznw2ciu	219	51	,	,	,
cord-016523-pznw2ciu	219	52	53	53	CD
cord-016523-pznw2ciu	219	53	]	]	-RRB-
cord-016523-pznw2ciu	219	54	signaling	signal	VBG
cord-016523-pznw2ciu	219	55	pathways	pathway	NNS
cord-016523-pznw2ciu	219	56	(	(	-LRB-
cord-016523-pznw2ciu	219	57	Fig	Fig	NNP
cord-016523-pznw2ciu	219	58	.	.	.
cord-016523-pznw2ciu	219	59	9.4	9.4	CD
cord-016523-pznw2ciu	219	60	)	)	-RRB-
cord-016523-pznw2ciu	219	61	.	.	.
cord-016523-pznw2ciu	220	1	Unlike	unlike	IN
cord-016523-pznw2ciu	220	2	transmembrane	transmembrane	NNP
cord-016523-pznw2ciu	220	3	CD95L	cd95l	NN
cord-016523-pznw2ciu	220	4	,	,	,
cord-016523-pznw2ciu	220	5	induction	induction	NN
cord-016523-pznw2ciu	220	6	of	of	IN
cord-016523-pznw2ciu	220	7	the	the	DT
cord-016523-pznw2ciu	220	8	PI3	PI3	NNP
cord-016523-pznw2ciu	220	9	K	K	NNP
cord-016523-pznw2ciu	220	10	signaling	signal	VBG
cord-016523-pznw2ciu	220	11	pathway	pathway	NN
cord-016523-pznw2ciu	220	12	by	by	IN
cord-016523-pznw2ciu	220	13	its	-PRON-	PRP$
cord-016523-pznw2ciu	220	14	metalloprotease	metalloprotease	NNP
cord-016523-pznw2ciu	220	15	-	-	HYPH
cord-016523-pznw2ciu	220	16	cleaved	cleave	VBN
cord-016523-pznw2ciu	220	17	counterpart	counterpart	NN
cord-016523-pznw2ciu	220	18	occurs	occur	VBZ
cord-016523-pznw2ciu	220	19	through	through	IN
cord-016523-pznw2ciu	220	20	the	the	DT
cord-016523-pznw2ciu	220	21	formation	formation	NN
cord-016523-pznw2ciu	220	22	of	of	IN
cord-016523-pznw2ciu	220	23	a	a	DT
cord-016523-pznw2ciu	220	24	complex	complex	JJ
cord-016523-pznw2ciu	220	25	devoid	devoid	NN
cord-016523-pznw2ciu	220	26	of	of	IN
cord-016523-pznw2ciu	220	27	FADD	FADD	NNP
cord-016523-pznw2ciu	220	28	and	and	CC
cord-016523-pznw2ciu	220	29	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	220	30	which	which	WDT
cord-016523-pznw2ciu	220	31	recruits	recruit	VBZ
cord-016523-pznw2ciu	220	32	the	the	DT
cord-016523-pznw2ciu	220	33	src	src	NNP
cord-016523-pznw2ciu	220	34	kinase	kinase	NNP
cord-016523-pznw2ciu	220	35	c	c	NNP
cord-016523-pznw2ciu	221	1	-yes	-yes	:
cord-016523-pznw2ciu	221	2	instead	instead	RB
cord-016523-pznw2ciu	221	3	[	[	-LRB-
cord-016523-pznw2ciu	221	4	53	53	CD
cord-016523-pznw2ciu	221	5	,	,	,
cord-016523-pznw2ciu	221	6	148	148	CD
cord-016523-pznw2ciu	221	7	]	]	-RRB-
cord-016523-pznw2ciu	221	8	;	;	:
cord-016523-pznw2ciu	221	9	this	this	DT
cord-016523-pznw2ciu	221	10	unconventional	unconventional	JJ
cord-016523-pznw2ciu	221	11	receptosome	receptosome	NNP
cord-016523-pznw2ciu	221	12	was	be	VBD
cord-016523-pznw2ciu	221	13	designated	designate	VBN
cord-016523-pznw2ciu	221	14	motilityinducing	motilityinduce	VBG
cord-016523-pznw2ciu	221	15	signaling	signal	VBG
cord-016523-pznw2ciu	221	16	complex	complex	NN
cord-016523-pznw2ciu	221	17	(	(	-LRB-
cord-016523-pznw2ciu	221	18	MISC	MISC	NNP
cord-016523-pznw2ciu	221	19	)	)	-RRB-
cord-016523-pznw2ciu	221	20	[	[	-LRB-
cord-016523-pznw2ciu	221	21	53	53	CD
cord-016523-pznw2ciu	221	22	,	,	,
cord-016523-pznw2ciu	221	23	157	157	CD
cord-016523-pznw2ciu	221	24	]	]	-RRB-
cord-016523-pznw2ciu	222	1	(	(	-LRB-
cord-016523-pznw2ciu	222	2	Fig	Fig	NNP
cord-016523-pznw2ciu	222	3	.	.	.
cord-016523-pznw2ciu	223	1	9.4	9.4	CD
cord-016523-pznw2ciu	223	2	)	)	-RRB-
cord-016523-pznw2ciu	223	3	.	.	.
cord-016523-pznw2ciu	224	1	Even	even	RB
cord-016523-pznw2ciu	224	2	though	though	IN
cord-016523-pznw2ciu	224	3	experiments	experiment	NNS
cord-016523-pznw2ciu	224	4	by	by	IN
cord-016523-pznw2ciu	224	5	the	the	DT
cord-016523-pznw2ciu	224	6	authors	author	NNS
cord-016523-pznw2ciu	224	7	did	do	VBD
cord-016523-pznw2ciu	224	8	not	not	RB
cord-016523-pznw2ciu	224	9	detect	detect	VB
cord-016523-pznw2ciu	224	10	any	any	DT
cord-016523-pznw2ciu	224	11	trace	trace	NN
cord-016523-pznw2ciu	224	12	of	of	IN
cord-016523-pznw2ciu	224	13	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	224	14	in	in	IN
cord-016523-pznw2ciu	224	15	the	the	DT
cord-016523-pznw2ciu	224	16	MISC	MISC	NNS
cord-016523-pznw2ciu	224	17	,	,	,
cord-016523-pznw2ciu	224	18	this	this	DT
cord-016523-pznw2ciu	224	19	enzyme	enzyme	NN
cord-016523-pznw2ciu	224	20	has	have	VBZ
cord-016523-pznw2ciu	224	21	been	be	VBN
cord-016523-pznw2ciu	224	22	shown	show	VBN
cord-016523-pznw2ciu	224	23	to	to	TO
cord-016523-pznw2ciu	224	24	participate	participate	VB
cord-016523-pznw2ciu	224	25	in	in	IN
cord-016523-pznw2ciu	224	26	cell	cell	NN
cord-016523-pznw2ciu	224	27	migration	migration	NN
cord-016523-pznw2ciu	224	28	.	.	.
cord-016523-pznw2ciu	225	1	The	the	DT
cord-016523-pznw2ciu	225	2	protease	protease	NN
cord-016523-pznw2ciu	225	3	activity	activity	NN
cord-016523-pznw2ciu	225	4	of	of	IN
cord-016523-pznw2ciu	225	5	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	225	6	can	can	MD
cord-016523-pznw2ciu	225	7	be	be	VB
cord-016523-pznw2ciu	225	8	abolished	abolish	VBN
cord-016523-pznw2ciu	225	9	by	by	IN
cord-016523-pznw2ciu	225	10	its	-PRON-	PRP$
cord-016523-pznw2ciu	225	11	phosphorylation	phosphorylation	NN
cord-016523-pznw2ciu	225	12	at	at	IN
cord-016523-pznw2ciu	225	13	tyrosine	tyrosine	NN
cord-016523-pznw2ciu	225	14	380	380	CD
cord-016523-pznw2ciu	225	15	by	by	IN
cord-016523-pznw2ciu	225	16	src	src	NNP
cord-016523-pznw2ciu	225	17	kinase	kinase	NNP
cord-016523-pznw2ciu	225	18	[	[	-LRB-
cord-016523-pznw2ciu	225	19	158	158	CD
cord-016523-pznw2ciu	225	20	]	]	-RRB-
cord-016523-pznw2ciu	225	21	.	.	.
cord-016523-pznw2ciu	226	1	This	this	DT
cord-016523-pznw2ciu	226	2	posttranslational	posttranslational	JJ
cord-016523-pznw2ciu	226	3	modifi	modifi	NNP
cord-016523-pznw2ciu	226	4	cation	cation	NN
cord-016523-pznw2ciu	226	5	was	be	VBD
cord-016523-pznw2ciu	226	6	observed	observe	VBN
cord-016523-pznw2ciu	226	7	in	in	IN
cord-016523-pznw2ciu	226	8	cells	cell	NNS
cord-016523-pznw2ciu	226	9	stimulated	stimulate	VBN
cord-016523-pznw2ciu	226	10	with	with	IN
cord-016523-pznw2ciu	226	11	EGF	EGF	NNP
cord-016523-pznw2ciu	226	12	and	and	CC
cord-016523-pznw2ciu	226	13	in	in	IN
cord-016523-pznw2ciu	226	14	colon	colon	NN
cord-016523-pznw2ciu	226	15	cancer	cancer	NN
cord-016523-pznw2ciu	226	16	cells	cell	NNS
cord-016523-pznw2ciu	226	17	exhibiting	exhibit	VBG
cord-016523-pznw2ciu	226	18	constitutive	constitutive	JJ
cord-016523-pznw2ciu	226	19	activation	activation	NN
cord-016523-pznw2ciu	226	20	of	of	IN
cord-016523-pznw2ciu	226	21	src	src	NNP
cord-016523-pznw2ciu	226	22	;	;	:
cord-016523-pznw2ciu	226	23	from	from	IN
cord-016523-pznw2ciu	226	24	a	a	DT
cord-016523-pznw2ciu	226	25	molecular	molecular	JJ
cord-016523-pznw2ciu	226	26	standpoint	standpoint	NN
cord-016523-pznw2ciu	226	27	,	,	,
cord-016523-pznw2ciu	226	28	this	this	DT
cord-016523-pznw2ciu	226	29	modifi	modifi	JJ
cord-016523-pznw2ciu	226	30	cation	cation	NN
cord-016523-pznw2ciu	226	31	does	do	VBZ
cord-016523-pznw2ciu	226	32	not	not	RB
cord-016523-pznw2ciu	226	33	alter	alter	VB
cord-016523-pznw2ciu	226	34	caspase	caspase	NN
cord-016523-pznw2ciu	226	35	homodimerization	homodimerization	NN
cord-016523-pznw2ciu	226	36	or	or	CC
cord-016523-pznw2ciu	226	37	recruitment	recruitment	NN
cord-016523-pznw2ciu	226	38	in	in	IN
cord-016523-pznw2ciu	226	39	DISC	DISC	NNP
cord-016523-pznw2ciu	226	40	[	[	-LRB-
cord-016523-pznw2ciu	226	41	158	158	CD
cord-016523-pznw2ciu	226	42	]	]	-RRB-
cord-016523-pznw2ciu	226	43	.	.	.
cord-016523-pznw2ciu	227	1	Moreover	moreover	RB
cord-016523-pznw2ciu	227	2	,	,	,
cord-016523-pznw2ciu	227	3	the	the	DT
cord-016523-pznw2ciu	227	4	EGFRdriven	egfrdriven	JJ
cord-016523-pznw2ciu	227	5	phosphorylation	phosphorylation	NN
cord-016523-pznw2ciu	227	6	of	of	IN
cord-016523-pznw2ciu	227	7	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	227	8	at	at	IN
cord-016523-pznw2ciu	227	9	Y380	Y380	NNP
cord-016523-pznw2ciu	227	10	turns	turn	NNS
cord-016523-pznw2ciu	227	11	out	out	RP
cord-016523-pznw2ciu	227	12	to	to	TO
cord-016523-pznw2ciu	227	13	be	be	VB
cord-016523-pznw2ciu	227	14	a	a	DT
cord-016523-pznw2ciu	227	15	potent	potent	JJ
cord-016523-pznw2ciu	227	16	inducer	inducer	NN
cord-016523-pznw2ciu	227	17	of	of	IN
cord-016523-pznw2ciu	227	18	the	the	DT
cord-016523-pznw2ciu	227	19	PI3	PI3	NNP
cord-016523-pznw2ciu	227	20	K	K	NNP
cord-016523-pznw2ciu	227	21	signaling	signal	VBG
cord-016523-pznw2ciu	227	22	pathway	pathway	NN
cord-016523-pznw2ciu	227	23	by	by	IN
cord-016523-pznw2ciu	227	24	recruiting	recruit	VBG
cord-016523-pznw2ciu	227	25	the	the	DT
cord-016523-pznw2ciu	227	26	PI3	pi3	NN
cord-016523-pznw2ciu	227	27	K	K	NNP
cord-016523-pznw2ciu	227	28	adaptor	adaptor	NN
cord-016523-pznw2ciu	227	29	p85	p85	NN
cord-016523-pznw2ciu	227	30	alpha	alpha	NN
cord-016523-pznw2ciu	227	31	subunit	subunit	NN
cord-016523-pznw2ciu	227	32	[	[	-LRB-
cord-016523-pznw2ciu	227	33	159	159	CD
cord-016523-pznw2ciu	227	34	]	]	-RRB-
cord-016523-pznw2ciu	227	35	.	.	.
cord-016523-pznw2ciu	228	1	Ultimately	ultimately	RB
cord-016523-pznw2ciu	228	2	,	,	,
cord-016523-pznw2ciu	228	3	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	228	4	phosphorylation	phosphorylation	NN
cord-016523-pznw2ciu	228	5	triggers	trigger	VBZ
cord-016523-pznw2ciu	228	6	cell	cell	NN
cord-016523-pznw2ciu	228	7	migration	migration	NN
cord-016523-pznw2ciu	228	8	.	.	.
cord-016523-pznw2ciu	229	1	Nonetheless	nonetheless	RB
cord-016523-pznw2ciu	229	2	,	,	,
cord-016523-pznw2ciu	229	3	it	-PRON-	PRP
cord-016523-pznw2ciu	229	4	is	be	VBZ
cord-016523-pznw2ciu	229	5	noteworthy	noteworthy	JJ
cord-016523-pznw2ciu	229	6	that	that	IN
cord-016523-pznw2ciu	229	7	CD95-induced	cd95-induced	CD
cord-016523-pznw2ciu	229	8	migration	migration	NN
cord-016523-pznw2ciu	229	9	and	and	CC
cord-016523-pznw2ciu	229	10	invasion	invasion	NN
cord-016523-pznw2ciu	229	11	do	do	VBP
cord-016523-pznw2ciu	229	12	not	not	RB
cord-016523-pznw2ciu	229	13	appear	appear	VB
cord-016523-pznw2ciu	229	14	to	to	TO
cord-016523-pznw2ciu	229	15	require	require	VB
cord-016523-pznw2ciu	229	16	an	an	DT
cord-016523-pznw2ciu	229	17	intact	intact	JJ
cord-016523-pznw2ciu	229	18	DD	dd	NN
cord-016523-pznw2ciu	229	19	(	(	-LRB-
cord-016523-pznw2ciu	229	20	reviewed	review	VBN
cord-016523-pznw2ciu	229	21	in	in	IN
cord-016523-pznw2ciu	229	22	[	[	-LRB-
cord-016523-pznw2ciu	229	23	160	160	CD
cord-016523-pznw2ciu	229	24	]	]	-RRB-
cord-016523-pznw2ciu	229	25	)	)	-RRB-
cord-016523-pznw2ciu	229	26	,	,	,
cord-016523-pznw2ciu	229	27	suggesting	suggest	VBG
cord-016523-pznw2ciu	229	28	that	that	IN
cord-016523-pznw2ciu	229	29	either	either	CC
cord-016523-pznw2ciu	229	30	the	the	DT
cord-016523-pznw2ciu	229	31	caspase-8-dependent	caspase-8-dependent	JJ
cord-016523-pznw2ciu	229	32	mode	mode	NN
cord-016523-pznw2ciu	229	33	of	of	IN
cord-016523-pznw2ciu	229	34	cell	cell	NN
cord-016523-pznw2ciu	229	35	migration	migration	NN
cord-016523-pznw2ciu	229	36	occurs	occur	VBZ
cord-016523-pznw2ciu	229	37	as	as	IN
cord-016523-pznw2ciu	229	38	an	an	DT
cord-016523-pznw2ciu	229	39	alternative	alternative	JJ
cord-016523-pznw2ciu	229	40	signal	signal	NN
cord-016523-pznw2ciu	229	41	for	for	IN
cord-016523-pznw2ciu	229	42	death	death	NN
cord-016523-pznw2ciu	229	43	receptors	receptor	NNS
cord-016523-pznw2ciu	229	44	or	or	CC
cord-016523-pznw2ciu	229	45	that	that	IN
cord-016523-pznw2ciu	229	46	it	-PRON-	PRP
cord-016523-pznw2ciu	229	47	only	only	RB
cord-016523-pznw2ciu	229	48	participates	participate	VBZ
cord-016523-pznw2ciu	229	49	in	in	IN
cord-016523-pznw2ciu	229	50	non	non	JJ
cord-016523-pznw2ciu	229	51	-	-	JJ
cord-016523-pznw2ciu	229	52	death	death	JJ
cord-016523-pznw2ciu	229	53	receptor	receptor	NN
cord-016523-pznw2ciu	229	54	-	-	HYPH
cord-016523-pznw2ciu	229	55	induced	induce	VBN
cord-016523-pznw2ciu	229	56	cell	cell	NN
cord-016523-pznw2ciu	229	57	motility	motility	NN
cord-016523-pznw2ciu	229	58	.	.	.
cord-016523-pznw2ciu	230	1	It	-PRON-	PRP
cord-016523-pznw2ciu	230	2	would	would	MD
cord-016523-pznw2ciu	230	3	be	be	VB
cord-016523-pznw2ciu	230	4	interesting	interesting	JJ
cord-016523-pznw2ciu	230	5	to	to	TO
cord-016523-pznw2ciu	230	6	address	address	VB
cord-016523-pznw2ciu	230	7	this	this	DT
cord-016523-pznw2ciu	230	8	question	question	NN
cord-016523-pznw2ciu	230	9	in	in	IN
cord-016523-pznw2ciu	230	10	the	the	DT
cord-016523-pznw2ciu	230	11	future	future	NN
cord-016523-pznw2ciu	230	12	.	.	.
cord-016523-pznw2ciu	231	1	To	to	IN
cord-016523-pznw2ciu	231	2	date	date	NN
cord-016523-pznw2ciu	231	3	,	,	,
cord-016523-pznw2ciu	231	4	it	-PRON-	PRP
cord-016523-pznw2ciu	231	5	can	can	MD
cord-016523-pznw2ciu	231	6	only	only	RB
cord-016523-pznw2ciu	231	7	be	be	VB
cord-016523-pznw2ciu	231	8	surmise	surmise	VBN
cord-016523-pznw2ciu	231	9	that	that	IN
cord-016523-pznw2ciu	231	10	phosphorylation	phosphorylation	NN
cord-016523-pznw2ciu	231	11	of	of	IN
cord-016523-pznw2ciu	231	12	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	231	13	at	at	IN
cord-016523-pznw2ciu	231	14	Y380	y380	RB
cord-016523-pznw2ciu	231	15	upon	upon	IN
cord-016523-pznw2ciu	231	16	EGFR	EGFR	NNP
cord-016523-pznw2ciu	231	17	stimulation	stimulation	NN
cord-016523-pznw2ciu	231	18	may	may	MD
cord-016523-pznw2ciu	231	19	prime	prime	VB
cord-016523-pznw2ciu	231	20	certain	certain	JJ
cord-016523-pznw2ciu	231	21	cancer	cancer	NN
cord-016523-pznw2ciu	231	22	cells	cell	NNS
cord-016523-pznw2ciu	231	23	to	to	TO
cord-016523-pznw2ciu	231	24	become	become	VB
cord-016523-pznw2ciu	231	25	unresponsive	unresponsive	JJ
cord-016523-pznw2ciu	231	26	to	to	IN
cord-016523-pznw2ciu	231	27	the	the	DT
cord-016523-pznw2ciu	231	28	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	231	29	signal	signal	NN
cord-016523-pznw2ciu	231	30	triggered	trigger	VBN
cord-016523-pznw2ciu	231	31	by	by	IN
cord-016523-pznw2ciu	231	32	cytotoxic	cytotoxic	JJ
cord-016523-pznw2ciu	231	33	CD95L	cd95l	NN
cord-016523-pznw2ciu	231	34	and	and	CC
cord-016523-pznw2ciu	231	35	meanwhile	meanwhile	RB
cord-016523-pznw2ciu	231	36	promote	promote	VB
cord-016523-pznw2ciu	231	37	cell	cell	NN
cord-016523-pznw2ciu	231	38	migration	migration	NN
cord-016523-pznw2ciu	231	39	,	,	,
cord-016523-pznw2ciu	231	40	an	an	DT
cord-016523-pznw2ciu	231	41	essential	essential	JJ
cord-016523-pznw2ciu	231	42	event	event	NN
cord-016523-pznw2ciu	231	43	in	in	IN
cord-016523-pznw2ciu	231	44	the	the	DT
cord-016523-pznw2ciu	231	45	course	course	NN
cord-016523-pznw2ciu	231	46	of	of	IN
cord-016523-pznw2ciu	231	47	cancer	cancer	NN
cord-016523-pznw2ciu	231	48	cell	cell	NN
cord-016523-pznw2ciu	231	49	metastasis	metastasis	NN
cord-016523-pznw2ciu	232	1	(	(	-LRB-
cord-016523-pznw2ciu	232	2	Fig	Fig	NNP
cord-016523-pznw2ciu	232	3	.	.	.
cord-016523-pznw2ciu	232	4	9.4	9.4	CD
cord-016523-pznw2ciu	232	5	)	)	-RRB-
cord-016523-pznw2ciu	232	6	.	.	.
cord-016523-pznw2ciu	233	1	It	-PRON-	PRP
cord-016523-pznw2ciu	233	2	is	be	VBZ
cord-016523-pznw2ciu	233	3	noteworthy	noteworthy	JJ
cord-016523-pznw2ciu	233	4	that	that	IN
cord-016523-pznw2ciu	233	5	in	in	IN
cord-016523-pznw2ciu	233	6	a	a	DT
cord-016523-pznw2ciu	233	7	similar	similar	JJ
cord-016523-pznw2ciu	233	8	manner	manner	NN
cord-016523-pznw2ciu	233	9	,	,	,
cord-016523-pznw2ciu	233	10	a	a	DT
cord-016523-pznw2ciu	233	11	decrease	decrease	NN
cord-016523-pznw2ciu	233	12	in	in	IN
cord-016523-pznw2ciu	233	13	the	the	DT
cord-016523-pznw2ciu	233	14	plasma	plasma	NN
cord-016523-pznw2ciu	233	15	membrane	membrane	NN
cord-016523-pznw2ciu	233	16	level	level	NN
cord-016523-pznw2ciu	233	17	of	of	IN
cord-016523-pznw2ciu	233	18	CD95	CD95	NNP
cord-016523-pznw2ciu	233	19	or	or	CC
cord-016523-pznw2ciu	233	20	expression	expression	NN
cord-016523-pznw2ciu	233	21	of	of	IN
cord-016523-pznw2ciu	233	22	a	a	DT
cord-016523-pznw2ciu	233	23	mutated	mutate	VBN
cord-016523-pznw2ciu	233	24	CD95	CD95	NNP
cord-016523-pznw2ciu	233	25	allele	allele	NN
cord-016523-pznw2ciu	233	26	,	,	,
cord-016523-pznw2ciu	233	27	as	as	IN
cord-016523-pznw2ciu	233	28	observed	observe	VBN
cord-016523-pznw2ciu	233	29	in	in	IN
cord-016523-pznw2ciu	233	30	ALPS	ALPS	NNP
cord-016523-pznw2ciu	233	31	patients	patient	NNS
cord-016523-pznw2ciu	233	32	and	and	CC
cord-016523-pznw2ciu	233	33	malignant	malignant	JJ
cord-016523-pznw2ciu	233	34	cells	cell	NNS
cord-016523-pznw2ciu	233	35	,	,	,
cord-016523-pznw2ciu	233	36	inhibits	inhibit	VBZ
cord-016523-pznw2ciu	233	37	the	the	DT
cord-016523-pznw2ciu	233	38	implementation	implementation	NN
cord-016523-pznw2ciu	233	39	of	of	IN
cord-016523-pznw2ciu	233	40	the	the	DT
cord-016523-pznw2ciu	233	41	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	233	42	signal	signal	NN
cord-016523-pznw2ciu	233	43	but	but	CC
cord-016523-pznw2ciu	233	44	does	do	VBZ
cord-016523-pznw2ciu	233	45	not	not	RB
cord-016523-pznw2ciu	233	46	affect	affect	VB
cord-016523-pznw2ciu	233	47	the	the	DT
cord-016523-pznw2ciu	233	48	transmission	transmission	NN
cord-016523-pznw2ciu	233	49	of	of	IN
cord-016523-pznw2ciu	233	50	non	non	JJ
cord-016523-pznw2ciu	233	51	-	-	JJ
cord-016523-pznw2ciu	233	52	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	233	53	signals	signal	NNS
cord-016523-pznw2ciu	233	54	,	,	,
cord-016523-pznw2ciu	233	55	such	such	JJ
cord-016523-pznw2ciu	233	56	as	as	IN
cord-016523-pznw2ciu	233	57	NF	NF	NNP
cord-016523-pznw2ciu	233	58	-	-	HYPH
cord-016523-pznw2ciu	233	59	κB	κB	NNP
cord-016523-pznw2ciu	233	60	,	,	,
cord-016523-pznw2ciu	233	61	MAPK	MAPK	NNP
cord-016523-pznw2ciu	233	62	,	,	,
cord-016523-pznw2ciu	233	63	and	and	CC
cord-016523-pznw2ciu	233	64	PI3	PI3	NNP
cord-016523-pznw2ciu	233	65	K	K	NNP
cord-016523-pznw2ciu	233	66	[	[	-LRB-
cord-016523-pznw2ciu	233	67	106	106	CD
cord-016523-pznw2ciu	233	68	,	,	,
cord-016523-pznw2ciu	233	69	107	107	CD
cord-016523-pznw2ciu	233	70	,	,	,
cord-016523-pznw2ciu	233	71	147	147	CD
cord-016523-pznw2ciu	233	72	]	]	-RRB-
cord-016523-pznw2ciu	233	73	,	,	,
cord-016523-pznw2ciu	233	74	suggesting	suggest	VBG
cord-016523-pznw2ciu	233	75	that	that	IN
cord-016523-pznw2ciu	233	76	these	these	DT
cord-016523-pznw2ciu	233	77	signals	signal	NNS
cord-016523-pznw2ciu	233	78	may	may	MD
cord-016523-pznw2ciu	233	79	stem	stem	VB
cord-016523-pznw2ciu	233	80	from	from	IN
cord-016523-pznw2ciu	233	81	a	a	DT
cord-016523-pznw2ciu	233	82	different	different	JJ
cord-016523-pznw2ciu	233	83	domain	domain	NN
cord-016523-pznw2ciu	233	84	than	than	IN
cord-016523-pznw2ciu	233	85	CD95-DD	cd95-dd	NN
cord-016523-pznw2ciu	233	86	or	or	CC
cord-016523-pznw2ciu	233	87	rely	rely	VB
cord-016523-pznw2ciu	233	88	on	on	IN
cord-016523-pznw2ciu	233	89	different	different	JJ
cord-016523-pznw2ciu	233	90	thresholds	threshold	NNS
cord-016523-pznw2ciu	233	91	to	to	TO
cord-016523-pznw2ciu	233	92	be	be	VB
cord-016523-pznw2ciu	233	93	elicited	elicit	VBN
cord-016523-pznw2ciu	233	94	.	.	.
cord-016523-pznw2ciu	234	1	In	in	IN
cord-016523-pznw2ciu	234	2	summary	summary	NN
cord-016523-pznw2ciu	234	3	,	,	,
cord-016523-pznw2ciu	234	4	although	although	IN
cord-016523-pznw2ciu	234	5	the	the	DT
cord-016523-pznw2ciu	234	6	CD95	CD95	NNP
cord-016523-pznw2ciu	234	7	/	/	SYM
cord-016523-pznw2ciu	234	8	CD95L	cd95l	NN
cord-016523-pznw2ciu	234	9	interaction	interaction	NN
cord-016523-pznw2ciu	234	10	can	can	MD
cord-016523-pznw2ciu	234	11	eliminate	eliminate	VB
cord-016523-pznw2ciu	234	12	malignant	malignant	JJ
cord-016523-pznw2ciu	234	13	cells	cell	NNS
cord-016523-pznw2ciu	234	14	by	by	IN
cord-016523-pznw2ciu	234	15	implementation	implementation	NN
cord-016523-pznw2ciu	234	16	of	of	IN
cord-016523-pznw2ciu	234	17	the	the	DT
cord-016523-pznw2ciu	234	18	DISC	disc	NN
cord-016523-pznw2ciu	234	19	or	or	CC
cord-016523-pznw2ciu	234	20	can	can	MD
cord-016523-pznw2ciu	234	21	promote	promote	VB
cord-016523-pznw2ciu	234	22	carcinogenesis	carcinogenesis	NN
cord-016523-pznw2ciu	234	23	by	by	IN
cord-016523-pznw2ciu	234	24	sustaining	sustain	VBG
cord-016523-pznw2ciu	234	25	infl	infl	NN
cord-016523-pznw2ciu	234	26	ammation	ammation	NN
cord-016523-pznw2ciu	234	27	and/or	and/or	CC
cord-016523-pznw2ciu	234	28	by	by	IN
cord-016523-pznw2ciu	234	29	inducing	induce	VBG
cord-016523-pznw2ciu	234	30	metastatic	metastatic	JJ
cord-016523-pznw2ciu	234	31	dissemination	dissemination	NN
cord-016523-pznw2ciu	234	32	[	[	-LRB-
cord-016523-pznw2ciu	234	33	50	50	CD
cord-016523-pznw2ciu	234	34	,	,	,
cord-016523-pznw2ciu	234	35	51	51	CD
cord-016523-pznw2ciu	234	36	,	,	,
cord-016523-pznw2ciu	234	37	53	53	CD
cord-016523-pznw2ciu	234	38	,	,	,
cord-016523-pznw2ciu	234	39	108	108	CD
cord-016523-pznw2ciu	234	40	,	,	,
cord-016523-pznw2ciu	234	41	147	147	CD
cord-016523-pznw2ciu	234	42	,	,	,
cord-016523-pznw2ciu	234	43	148	148	CD
cord-016523-pznw2ciu	234	44	,	,	,
cord-016523-pznw2ciu	234	45	161	161	CD
cord-016523-pznw2ciu	234	46	]	]	-RRB-
cord-016523-pznw2ciu	234	47	,	,	,
cord-016523-pznw2ciu	234	48	the	the	DT
cord-016523-pznw2ciu	234	49	molecular	molecular	JJ
cord-016523-pznw2ciu	234	50	mechanisms	mechanism	NNS
cord-016523-pznw2ciu	234	51	underlying	underlie	VBG
cord-016523-pznw2ciu	234	52	the	the	DT
cord-016523-pznw2ciu	234	53	switch	switch	NN
cord-016523-pznw2ciu	234	54	between	between	IN
cord-016523-pznw2ciu	234	55	these	these	DT
cord-016523-pznw2ciu	234	56	different	different	JJ
cord-016523-pznw2ciu	234	57	signaling	signal	VBG
cord-016523-pznw2ciu	234	58	pathways	pathway	NNS
cord-016523-pznw2ciu	234	59	remain	remain	VBP
cord-016523-pznw2ciu	234	60	enigmatic	enigmatic	JJ
cord-016523-pznw2ciu	234	61	.	.	.
cord-016523-pznw2ciu	235	1	An	an	DT
cord-016523-pznw2ciu	235	2	important	important	JJ
cord-016523-pznw2ciu	235	3	question	question	NN
cord-016523-pznw2ciu	235	4	to	to	TO
cord-016523-pznw2ciu	235	5	be	be	VB
cord-016523-pznw2ciu	235	6	addressed	address	VBN
cord-016523-pznw2ciu	235	7	is	be	VBZ
cord-016523-pznw2ciu	235	8	how	how	WRB
cord-016523-pznw2ciu	235	9	the	the	DT
cord-016523-pznw2ciu	235	10	magnitude	magnitude	NN
cord-016523-pznw2ciu	235	11	of	of	IN
cord-016523-pznw2ciu	235	12	CD95	CD95	NNP
cord-016523-pznw2ciu	235	13	aggregation	aggregation	NN
cord-016523-pznw2ciu	235	14	controls	control	VBZ
cord-016523-pznw2ciu	235	15	the	the	DT
cord-016523-pznw2ciu	235	16	formation	formation	NN
cord-016523-pznw2ciu	235	17	of	of	IN
cord-016523-pznw2ciu	235	18	"	"	``
cord-016523-pznw2ciu	235	19	death"vs	death"vs	''
cord-016523-pznw2ciu	235	20	.	.	.
cord-016523-pznw2ciu	235	21	"	"	''
cord-016523-pznw2ciu	236	1	motility"-ISCs	motility"-iscs	UH
cord-016523-pznw2ciu	236	2	.	.	.
cord-016523-pznw2ciu	237	1	Addressing	address	VBG
cord-016523-pznw2ciu	237	2	these	these	DT
cord-016523-pznw2ciu	237	3	questions	question	NNS
cord-016523-pznw2ciu	237	4	will	will	MD
cord-016523-pznw2ciu	237	5	lead	lead	VB
cord-016523-pznw2ciu	237	6	to	to	IN
cord-016523-pznw2ciu	237	7	the	the	DT
cord-016523-pznw2ciu	237	8	development	development	NN
cord-016523-pznw2ciu	237	9	of	of	IN
cord-016523-pznw2ciu	237	10	new	new	JJ
cord-016523-pznw2ciu	237	11	therapeutic	therapeutic	JJ
cord-016523-pznw2ciu	237	12	agents	agent	NNS
cord-016523-pznw2ciu	237	13	with	with	IN
cord-016523-pznw2ciu	237	14	the	the	DT
cord-016523-pznw2ciu	237	15	ability	ability	NN
cord-016523-pznw2ciu	237	16	to	to	TO
cord-016523-pznw2ciu	237	17	contain	contain	VB
cord-016523-pznw2ciu	237	18	the	the	DT
cord-016523-pznw2ciu	237	19	spread	spread	NN
cord-016523-pznw2ciu	237	20	of	of	IN
cord-016523-pznw2ciu	237	21	infl	infl	NN
cord-016523-pznw2ciu	237	22	ammation	ammation	NN
cord-016523-pznw2ciu	237	23	or	or	CC
cord-016523-pznw2ciu	237	24	impede	impede	VB
cord-016523-pznw2ciu	237	25	carcinogenesis	carcinogenesis	NN
cord-016523-pznw2ciu	237	26	at	at	IN
cord-016523-pznw2ciu	237	27	least	least	JJS
cord-016523-pznw2ciu	237	28	in	in	IN
cord-016523-pznw2ciu	237	29	pathologies	pathology	NNS
cord-016523-pznw2ciu	237	30	involving	involve	VBG
cord-016523-pznw2ciu	237	31	increased	increase	VBN
cord-016523-pznw2ciu	237	32	soluble	soluble	JJ
cord-016523-pznw2ciu	237	33	CD95L	cd95l	NN
cord-016523-pznw2ciu	237	34	such	such	JJ
cord-016523-pznw2ciu	237	35	as	as	IN
cord-016523-pznw2ciu	237	36	cancers	cancer	NNS
cord-016523-pznw2ciu	237	37	(	(	-LRB-
cord-016523-pznw2ciu	237	38	e.g.	e.g.	RB
cord-016523-pznw2ciu	237	39	,	,	,
cord-016523-pznw2ciu	237	40	pancreatic	pancreatic	JJ
cord-016523-pznw2ciu	237	41	cancer	cancer	NN
cord-016523-pznw2ciu	237	42	[	[	-LRB-
cord-016523-pznw2ciu	237	43	162	162	CD
cord-016523-pznw2ciu	237	44	]	]	-RRB-
cord-016523-pznw2ciu	237	45	,	,	,
cord-016523-pznw2ciu	237	46	large	large	JJ
cord-016523-pznw2ciu	237	47	granular	granular	JJ
cord-016523-pznw2ciu	237	48	lymphocytic	lymphocytic	JJ
cord-016523-pznw2ciu	237	49	leukemia	leukemia	NN
cord-016523-pznw2ciu	237	50	,	,	,
cord-016523-pznw2ciu	237	51	breast	breast	NN
cord-016523-pznw2ciu	237	52	cancer	cancer	NN
cord-016523-pznw2ciu	237	53	[	[	-LRB-
cord-016523-pznw2ciu	237	54	157	157	CD
cord-016523-pznw2ciu	237	55	]	]	-RRB-
cord-016523-pznw2ciu	237	56	,	,	,
cord-016523-pznw2ciu	237	57	and	and	CC
cord-016523-pznw2ciu	237	58	NK	NK	NNP
cord-016523-pznw2ciu	237	59	cell	cell	NN
cord-016523-pznw2ciu	237	60	lymphoma	lymphoma	NN
cord-016523-pznw2ciu	237	61	[	[	-LRB-
cord-016523-pznw2ciu	237	62	163	163	CD
cord-016523-pznw2ciu	237	63	]	]	-RRB-
cord-016523-pznw2ciu	237	64	)	)	-RRB-
cord-016523-pznw2ciu	237	65	or	or	CC
cord-016523-pznw2ciu	237	66	autoimmune	autoimmune	JJ
cord-016523-pznw2ciu	237	67	disorders	disorder	NNS
cord-016523-pznw2ciu	237	68	(	(	-LRB-
cord-016523-pznw2ciu	237	69	e.g.	e.g.	RB
cord-016523-pznw2ciu	237	70	,	,	,
cord-016523-pznw2ciu	237	71	rheumatoid	rheumatoid	NN
cord-016523-pznw2ciu	237	72	arthritis	arthritis	NN
cord-016523-pznw2ciu	237	73	and	and	CC
cord-016523-pznw2ciu	237	74	osteoarthritis	osteoarthritis	NN
cord-016523-pznw2ciu	237	75	[	[	-LRB-
cord-016523-pznw2ciu	237	76	164	164	CD
cord-016523-pznw2ciu	237	77	]	]	-RRB-
cord-016523-pznw2ciu	237	78	,	,	,
cord-016523-pznw2ciu	237	79	graft	graft	NN
cord-016523-pznw2ciu	237	80	-	-	HYPH
cord-016523-pznw2ciu	237	81	versus	versus	IN
cord-016523-pznw2ciu	237	82	-	-	HYPH
cord-016523-pznw2ciu	237	83	host	host	NN
cord-016523-pznw2ciu	237	84	-	-	HYPH
cord-016523-pznw2ciu	237	85	disease	disease	NN
cord-016523-pznw2ciu	237	86	(	(	-LRB-
cord-016523-pznw2ciu	237	87	GVDH	GVDH	NNP
cord-016523-pznw2ciu	237	88	)	)	-RRB-
cord-016523-pznw2ciu	237	89	[	[	-LRB-
cord-016523-pznw2ciu	237	90	165	165	CD
cord-016523-pznw2ciu	237	91	,	,	,
cord-016523-pznw2ciu	237	92	166	166	CD
cord-016523-pznw2ciu	237	93	]	]	-RRB-
cord-016523-pznw2ciu	237	94	or	or	CC
cord-016523-pznw2ciu	237	95	SLE	SLE	NNP
cord-016523-pznw2ciu	237	96	[	[	-LRB-
cord-016523-pznw2ciu	237	97	53	53	CD
cord-016523-pznw2ciu	237	98	,	,	,
cord-016523-pznw2ciu	237	99	167	167	CD
cord-016523-pznw2ciu	237	100	]	]	-RRB-
cord-016523-pznw2ciu	237	101	)	)	-RRB-
cord-016523-pznw2ciu	237	102	.	.	.
cord-016523-pznw2ciu	238	1	Altogether	altogether	RB
cord-016523-pznw2ciu	238	2	,	,	,
cord-016523-pznw2ciu	238	3	these	these	DT
cord-016523-pznw2ciu	238	4	studies	study	NNS
cord-016523-pznw2ciu	238	5	support	support	VBP
cord-016523-pznw2ciu	238	6	the	the	DT
cord-016523-pznw2ciu	238	7	notion	notion	NN
cord-016523-pznw2ciu	238	8	that	that	IN
cord-016523-pznw2ciu	238	9	the	the	DT
cord-016523-pznw2ciu	238	10	death	death	NN
cord-016523-pznw2ciu	238	11	function	function	NN
cord-016523-pznw2ciu	238	12	of	of	IN
cord-016523-pznw2ciu	238	13	CD95	CD95	NNP
cord-016523-pznw2ciu	238	14	may	may	MD
cord-016523-pznw2ciu	238	15	correspond	correspond	VB
cord-016523-pznw2ciu	238	16	to	to	IN
cord-016523-pznw2ciu	238	17	its	-PRON-	PRP$
cord-016523-pznw2ciu	238	18	"	"	``
cord-016523-pznw2ciu	238	19	day	day	NN
cord-016523-pznw2ciu	238	20	job	job	NN
cord-016523-pznw2ciu	238	21	,	,	,
cord-016523-pznw2ciu	238	22	"	"	''
cord-016523-pznw2ciu	238	23	while	while	IN
cord-016523-pznw2ciu	238	24	the	the	DT
cord-016523-pznw2ciu	238	25	receptor	receptor	NN
cord-016523-pznw2ciu	238	26	may	may	MD
cord-016523-pznw2ciu	238	27	act	act	VB
cord-016523-pznw2ciu	238	28	as	as	IN
cord-016523-pznw2ciu	238	29	"	"	``
cord-016523-pznw2ciu	238	30	a	a	DT
cord-016523-pznw2ciu	238	31	night	night	NN
cord-016523-pznw2ciu	238	32	killer	killer	NN
cord-016523-pznw2ciu	238	33	"	"	''
cord-016523-pznw2ciu	238	34	by	by	IN
cord-016523-pznw2ciu	238	35	fueling	fuel	VBG
cord-016523-pznw2ciu	238	36	infl	infl	NN
cord-016523-pznw2ciu	238	37	ammation	ammation	NN
cord-016523-pznw2ciu	238	38	in	in	IN
cord-016523-pznw2ciu	238	39	certain	certain	JJ
cord-016523-pznw2ciu	238	40	pathophysiological	pathophysiological	JJ
cord-016523-pznw2ciu	238	41	contexts	context	NNS
cord-016523-pznw2ciu	238	42	.	.	.
cord-016523-pznw2ciu	239	1	Strikingly	strikingly	RB
cord-016523-pznw2ciu	239	2	,	,	,
cord-016523-pznw2ciu	239	3	while	while	IN
cord-016523-pznw2ciu	239	4	the	the	DT
cord-016523-pznw2ciu	239	5	soluble	soluble	JJ
cord-016523-pznw2ciu	239	6	form	form	NN
cord-016523-pznw2ciu	239	7	of	of	IN
cord-016523-pznw2ciu	239	8	CD95L	cd95l	NN
cord-016523-pznw2ciu	239	9	generated	generate	VBN
cord-016523-pznw2ciu	239	10	by	by	IN
cord-016523-pznw2ciu	239	11	MMP7	MMP7	NNP
cord-016523-pznw2ciu	240	1	(	(	-LRB-
cord-016523-pznw2ciu	240	2	cleavage	cleavage	NN
cord-016523-pznw2ciu	240	3	site	site	NN
cord-016523-pznw2ciu	240	4	inside	inside	IN
cord-016523-pznw2ciu	240	5	the	the	DT
cord-016523-pznw2ciu	240	6	113	113	CD
cord-016523-pznw2ciu	240	7	ELR	ELR	NNP
cord-016523-pznw2ciu	240	8	115	115	CD
cord-016523-pznw2ciu	240	9	sequence	sequence	NN
cord-016523-pznw2ciu	240	10	,	,	,
cord-016523-pznw2ciu	240	11	Fig	Fig	NNP
cord-016523-pznw2ciu	240	12	.	.	.
cord-016523-pznw2ciu	241	1	9	9	LS
cord-016523-pznw2ciu	241	2	.5	.5	CD
cord-016523-pznw2ciu	241	3	)	)	-RRB-
cord-016523-pznw2ciu	241	4	induces	induce	VBZ
cord-016523-pznw2ciu	241	5	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	241	6	[	[	-LRB-
cord-016523-pznw2ciu	241	7	150	150	CD
cord-016523-pznw2ciu	241	8	]	]	-RRB-
cord-016523-pznw2ciu	241	9	,	,	.
cord-016523-pznw2ciu	242	1	its	-PRON-	PRP$
cord-016523-pznw2ciu	242	2	counterpart	counterpart	NN
cord-016523-pznw2ciu	242	3	processed	process	VBN
cord-016523-pznw2ciu	242	4	between	between	IN
cord-016523-pznw2ciu	242	5	serine	serine	NN
cord-016523-pznw2ciu	242	6	126	126	CD
cord-016523-pznw2ciu	242	7	and	and	CC
cord-016523-pznw2ciu	242	8	leucine	leucine	NN
cord-016523-pznw2ciu	242	9	127	127	CD
cord-016523-pznw2ciu	242	10	does	do	VBZ
cord-016523-pznw2ciu	242	11	not	not	RB
cord-016523-pznw2ciu	242	12	[	[	-LRB-
cord-016523-pznw2ciu	242	13	51	51	CD
cord-016523-pznw2ciu	242	14	,	,	,
cord-016523-pznw2ciu	242	15	53	53	CD
cord-016523-pznw2ciu	242	16	,	,	,
cord-016523-pznw2ciu	242	17	155	155	CD
cord-016523-pznw2ciu	242	18	]	]	-RRB-
cord-016523-pznw2ciu	242	19	.	.	.
cord-016523-pznw2ciu	243	1	To	to	TO
cord-016523-pznw2ciu	243	2	explain	explain	VB
cord-016523-pznw2ciu	243	3	this	this	DT
cord-016523-pznw2ciu	243	4	discrepancy	discrepancy	NN
cord-016523-pznw2ciu	243	5	,	,	,
cord-016523-pznw2ciu	243	6	one	one	PRP
cord-016523-pznw2ciu	243	7	may	may	MD
cord-016523-pznw2ciu	243	8	speculate	speculate	VB
cord-016523-pznw2ciu	243	9	that	that	IN
cord-016523-pznw2ciu	243	10	the	the	DT
cord-016523-pznw2ciu	243	11	different	different	JJ
cord-016523-pznw2ciu	243	12	quaternary	quaternary	JJ
cord-016523-pznw2ciu	243	13	structures	structure	NNS
cord-016523-pznw2ciu	243	14	of	of	IN
cord-016523-pznw2ciu	243	15	the	the	DT
cord-016523-pznw2ciu	243	16	naturally	naturally	RB
cord-016523-pznw2ciu	243	17	processed	process	VBN
cord-016523-pznw2ciu	243	18	CD95L	CD95L	NNS
cord-016523-pznw2ciu	243	19	underlie	underlie	VBP
cord-016523-pznw2ciu	243	20	the	the	DT
cord-016523-pznw2ciu	244	1	In	in	IN
cord-016523-pznw2ciu	244	2	the	the	DT
cord-016523-pznw2ciu	244	3	presence	presence	NN
cord-016523-pznw2ciu	244	4	of	of	IN
cord-016523-pznw2ciu	244	5	cl	cl	NNP
cord-016523-pznw2ciu	244	6	-	-	HYPH
cord-016523-pznw2ciu	244	7	CD95L	CD95L	NNP
cord-016523-pznw2ciu	244	8	,	,	,
cord-016523-pznw2ciu	244	9	CD95	CD95	NNP
cord-016523-pznw2ciu	244	10	triggers	trigger	VBZ
cord-016523-pznw2ciu	244	11	MISC	MISC	NNP
cord-016523-pznw2ciu	244	12	formation	formation	NN
cord-016523-pznw2ciu	244	13	.	.	.
cord-016523-pznw2ciu	245	1	This	this	DT
cord-016523-pznw2ciu	245	2	complex	complex	NN
cord-016523-pznw2ciu	245	3	is	be	VBZ
cord-016523-pznw2ciu	245	4	devoid	devoid	JJ
cord-016523-pznw2ciu	245	5	of	of	IN
cord-016523-pznw2ciu	245	6	FADD	FADD	NNP
cord-016523-pznw2ciu	245	7	and	and	CC
cord-016523-pznw2ciu	245	8	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	245	9	,	,	,
cord-016523-pznw2ciu	245	10	but	but	CC
cord-016523-pznw2ciu	245	11	,	,	,
cord-016523-pznw2ciu	245	12	instead	instead	RB
cord-016523-pznw2ciu	245	13	,	,	,
cord-016523-pznw2ciu	245	14	recruits	recruit	VBZ
cord-016523-pznw2ciu	245	15	the	the	DT
cord-016523-pznw2ciu	245	16	src	src	NNP
cord-016523-pznw2ciu	245	17	kinase	kinase	NNP
cord-016523-pznw2ciu	245	18	c	c	NNP
cord-016523-pznw2ciu	245	19	-	-	:
cord-016523-pznw2ciu	245	20	yes	yes	UH
cord-016523-pznw2ciu	245	21	that	that	WDT
cord-016523-pznw2ciu	245	22	implements	implement	VBZ
cord-016523-pznw2ciu	245	23	the	the	DT
cord-016523-pznw2ciu	245	24	PI3	pi3	NN
cord-016523-pznw2ciu	245	25	K	K	NNP
cord-016523-pznw2ciu	245	26	signaling	signal	VBG
cord-016523-pznw2ciu	245	27	pathway	pathway	NN
cord-016523-pznw2ciu	245	28	.	.	.
cord-016523-pznw2ciu	246	1	CD95	CD95	NNP
cord-016523-pznw2ciu	246	2	engagement	engagement	NN
cord-016523-pznw2ciu	246	3	is	be	VBZ
cord-016523-pznw2ciu	246	4	also	also	RB
cord-016523-pznw2ciu	246	5	capable	capable	JJ
cord-016523-pznw2ciu	246	6	of	of	IN
cord-016523-pznw2ciu	246	7	NF	nf	NN
cord-016523-pznw2ciu	246	8	-	-	HYPH
cord-016523-pznw2ciu	246	9	κB	κB	NNP
cord-016523-pznw2ciu	246	10	and	and	CC
cord-016523-pznw2ciu	246	11	MAPK	MAPK	NNP
cord-016523-pznw2ciu	246	12	activations	activation	NNS
cord-016523-pznw2ciu	246	13	through	through	IN
cord-016523-pznw2ciu	246	14	a	a	DT
cord-016523-pznw2ciu	246	15	yet	yet	RB
cord-016523-pznw2ciu	246	16	unknown	unknown	JJ
cord-016523-pznw2ciu	246	17	mechanism	mechanism	NN
cord-016523-pznw2ciu	246	18	.	.	.
cord-016523-pznw2ciu	247	1	Right	Right	NNP
cord-016523-pznw2ciu	247	2	Panel	panel	NN
cord-016523-pznw2ciu	247	3	:	:	:
cord-016523-pznw2ciu	247	4	It	-PRON-	PRP
cord-016523-pznw2ciu	247	5	was	be	VBD
cord-016523-pznw2ciu	247	6	reported	report	VBN
cord-016523-pznw2ciu	247	7	that	that	IN
cord-016523-pznw2ciu	247	8	procaspase-8	procaspase-8	NNP
cord-016523-pznw2ciu	247	9	can	can	MD
cord-016523-pznw2ciu	247	10	be	be	VB
cord-016523-pznw2ciu	247	11	phosphorylated	phosphorylate	VBN
cord-016523-pznw2ciu	247	12	by	by	IN
cord-016523-pznw2ciu	247	13	the	the	DT
cord-016523-pznw2ciu	247	14	tyrosine	tyrosine	NN
cord-016523-pznw2ciu	247	15	kinase	kinase	VBN
cord-016523-pznw2ciu	247	16	src	src	NNP
cord-016523-pznw2ciu	247	17	upon	upon	IN
cord-016523-pznw2ciu	247	18	EGFR	EGFR	NNP
cord-016523-pznw2ciu	247	19	stimulation	stimulation	NN
cord-016523-pznw2ciu	247	20	.	.	.
cord-016523-pznw2ciu	248	1	This	this	DT
cord-016523-pznw2ciu	248	2	posttranslational	posttranslational	JJ
cord-016523-pznw2ciu	248	3	modifi	modifi	NNP
cord-016523-pznw2ciu	248	4	cation	cation	NN
cord-016523-pznw2ciu	249	1	not	not	RB
cord-016523-pznw2ciu	249	2	only	only	RB
cord-016523-pznw2ciu	249	3	blocks	block	VBZ
cord-016523-pznw2ciu	249	4	the	the	DT
cord-016523-pznw2ciu	249	5	catalytic	catalytic	JJ
cord-016523-pznw2ciu	249	6	activity	activity	NN
cord-016523-pznw2ciu	249	7	of	of	IN
cord-016523-pznw2ciu	249	8	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	249	9	but	but	CC
cord-016523-pznw2ciu	249	10	also	also	RB
cord-016523-pznw2ciu	249	11	promotes	promote	VBZ
cord-016523-pznw2ciu	249	12	the	the	DT
cord-016523-pznw2ciu	249	13	recruitment	recruitment	NN
cord-016523-pznw2ciu	249	14	of	of	IN
cord-016523-pznw2ciu	249	15	the	the	DT
cord-016523-pznw2ciu	249	16	p85	p85	NN
cord-016523-pznw2ciu	249	17	subunit	subunit	NN
cord-016523-pznw2ciu	249	18	of	of	IN
cord-016523-pznw2ciu	249	19	PI3K.	PI3K.	NNP
cord-016523-pznw2ciu	250	1	We	-PRON-	PRP
cord-016523-pznw2ciu	250	2	surmise	surmise	VBP
cord-016523-pznw2ciu	250	3	that	that	IN
cord-016523-pznw2ciu	250	4	this	this	DT
cord-016523-pznw2ciu	250	5	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	250	6	phosphorylation	phosphorylation	NN
cord-016523-pznw2ciu	250	7	may	may	MD
cord-016523-pznw2ciu	250	8	favor	favor	VB
cord-016523-pznw2ciu	250	9	the	the	DT
cord-016523-pznw2ciu	250	10	non	non	JJ
cord-016523-pznw2ciu	250	11	-	-	JJ
cord-016523-pznw2ciu	250	12	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	250	13	signals	signal	NNS
cord-016523-pznw2ciu	250	14	induced	induce	VBN
cord-016523-pznw2ciu	250	15	by	by	IN
cord-016523-pznw2ciu	250	16	CD95	CD95	NNP
cord-016523-pznw2ciu	250	17	implementation	implementation	NN
cord-016523-pznw2ciu	250	18	of	of	IN
cord-016523-pznw2ciu	250	19	a	a	DT
cord-016523-pznw2ciu	250	20	"	"	``
cord-016523-pznw2ciu	250	21	death"vs	death"vs	CD
cord-016523-pznw2ciu	250	22	.	.	.
cord-016523-pznw2ciu	250	23	"	"	''
cord-016523-pznw2ciu	250	24	non	non	JJ
cord-016523-pznw2ciu	250	25	-	-	JJ
cord-016523-pznw2ciu	250	26	death"inducing	death"inducing	JJ
cord-016523-pznw2ciu	250	27	signaling	signal	VBG
cord-016523-pznw2ciu	250	28	complexes	complex	NNS
cord-016523-pznw2ciu	250	29	and	and	CC
cord-016523-pznw2ciu	250	30	downstream	downstream	JJ
cord-016523-pznw2ciu	250	31	signals	signal	NNS
cord-016523-pznw2ciu	250	32	.	.	.
cord-016523-pznw2ciu	251	1	In	in	IN
cord-016523-pznw2ciu	251	2	agreement	agreement	NN
cord-016523-pznw2ciu	251	3	with	with	IN
cord-016523-pznw2ciu	251	4	this	this	DT
cord-016523-pznw2ciu	251	5	notion	notion	NN
cord-016523-pznw2ciu	251	6	,	,	,
cord-016523-pznw2ciu	251	7	soluble	soluble	JJ
cord-016523-pznw2ciu	251	8	CD95L	cd95l	NN
cord-016523-pznw2ciu	251	9	bathed	bathe	VBN
cord-016523-pznw2ciu	251	10	in	in	IN
cord-016523-pznw2ciu	251	11	the	the	DT
cord-016523-pznw2ciu	251	12	bronchoalveolar	bronchoalveolar	NNP
cord-016523-pznw2ciu	251	13	lavage	lavage	NNP
cord-016523-pznw2ciu	251	14	(	(	-LRB-
cord-016523-pznw2ciu	251	15	BALs	BALs	NNP
cord-016523-pznw2ciu	251	16	)	)	-RRB-
cord-016523-pznw2ciu	251	17	of	of	IN
cord-016523-pznw2ciu	251	18	patients	patient	NNS
cord-016523-pznw2ciu	251	19	suffering	suffer	VBG
cord-016523-pznw2ciu	251	20	from	from	IN
cord-016523-pznw2ciu	251	21	acute	acute	JJ
cord-016523-pznw2ciu	251	22	respiratory	respiratory	JJ
cord-016523-pznw2ciu	251	23	distress	distress	NN
cord-016523-pznw2ciu	251	24	syndrome	syndrome	NN
cord-016523-pznw2ciu	251	25	(	(	-LRB-
cord-016523-pznw2ciu	251	26	ARDS	ARDS	NNP
cord-016523-pznw2ciu	251	27	)	)	-RRB-
cord-016523-pznw2ciu	251	28	undergoes	undergo	VBZ
cord-016523-pznw2ciu	251	29	oxidation	oxidation	NN
cord-016523-pznw2ciu	251	30	at	at	IN
cord-016523-pznw2ciu	251	31	methionines	methionines	NNP
cord-016523-pznw2ciu	251	32	224	224	CD
cord-016523-pznw2ciu	251	33	and	and	CC
cord-016523-pznw2ciu	251	34	225	225	CD
cord-016523-pznw2ciu	251	35	(	(	-LRB-
cord-016523-pznw2ciu	251	36	Fig	fig	NN
cord-016523-pznw2ciu	251	37	.	.	.
cord-016523-pznw2ciu	252	1	9	9	CD
cord-016523-pznw2ciu	252	2	.5	.5	CD
cord-016523-pznw2ciu	252	3	)	)	-RRB-
cord-016523-pznw2ciu	252	4	,	,	,
cord-016523-pznw2ciu	252	5	which	which	WDT
cord-016523-pznw2ciu	252	6	enhances	enhance	VBZ
cord-016523-pznw2ciu	252	7	the	the	DT
cord-016523-pznw2ciu	252	8	aggregation	aggregation	NN
cord-016523-pznw2ciu	252	9	level	level	NN
cord-016523-pznw2ciu	252	10	of	of	IN
cord-016523-pznw2ciu	252	11	the	the	DT
cord-016523-pznw2ciu	252	12	soluble	soluble	JJ
cord-016523-pznw2ciu	252	13	ligand	ligand	NN
cord-016523-pznw2ciu	252	14	followed	follow	VBN
cord-016523-pznw2ciu	252	15	by	by	IN
cord-016523-pznw2ciu	252	16	its	-PRON-	PRP$
cord-016523-pznw2ciu	252	17	cytotoxic	cytotoxic	JJ
cord-016523-pznw2ciu	252	18	activity	activity	NN
cord-016523-pznw2ciu	252	19	[	[	-LRB-
cord-016523-pznw2ciu	252	20	168	168	CD
cord-016523-pznw2ciu	252	21	]	]	-RRB-
cord-016523-pznw2ciu	252	22	.	.	.
cord-016523-pznw2ciu	253	1	The	the	DT
cord-016523-pznw2ciu	253	2	same	same	JJ
cord-016523-pznw2ciu	253	3	authors	author	NNS
cord-016523-pznw2ciu	253	4	observed	observe	VBD
cord-016523-pznw2ciu	253	5	that	that	IN
cord-016523-pznw2ciu	253	6	the	the	DT
cord-016523-pznw2ciu	253	7	stalk	stalk	NN
cord-016523-pznw2ciu	253	8	region	region	NN
cord-016523-pznw2ciu	253	9	of	of	IN
cord-016523-pznw2ciu	253	10	CD95L	cd95l	NN
cord-016523-pznw2ciu	253	11	,	,	,
cord-016523-pznw2ciu	253	12	corresponding	correspond	VBG
cord-016523-pznw2ciu	253	13	to	to	IN
cord-016523-pznw2ciu	253	14	amino	amino	JJ
cord-016523-pznw2ciu	253	15	acids	acid	NNS
cord-016523-pznw2ciu	253	16	103	103	CD
cord-016523-pznw2ciu	253	17	-	-	SYM
cord-016523-pznw2ciu	253	18	136	136	CD
cord-016523-pznw2ciu	253	19	and	and	CC
cord-016523-pznw2ciu	253	20	encompassing	encompass	VBG
cord-016523-pznw2ciu	253	21	the	the	DT
cord-016523-pznw2ciu	253	22	metalloprotease	metalloprotease	NNP
cord-016523-pznw2ciu	253	23	cleavage	cleavage	NN
cord-016523-pznw2ciu	253	24	sites	site	NNS
cord-016523-pznw2ciu	253	25	(	(	-LRB-
cord-016523-pznw2ciu	253	26	Fig	Fig	NNP
cord-016523-pznw2ciu	253	27	.	.	.
cord-016523-pznw2ciu	253	28	9	9	CD
cord-016523-pznw2ciu	253	29	.5	.5	CD
cord-016523-pznw2ciu	253	30	)	)	-RRB-
cord-016523-pznw2ciu	253	31	,	,	,
cord-016523-pznw2ciu	253	32	participates	participate	VBZ
cord-016523-pznw2ciu	253	33	in	in	IN
cord-016523-pznw2ciu	253	34	the	the	DT
cord-016523-pznw2ciu	253	35	multimerization	multimerization	NN
cord-016523-pznw2ciu	253	36	of	of	IN
cord-016523-pznw2ciu	253	37	CD95L	CD95L	NNP
cord-016523-pznw2ciu	253	38	,	,	,
cord-016523-pznw2ciu	253	39	which	which	WDT
cord-016523-pznw2ciu	253	40	accounts	account	VBZ
cord-016523-pznw2ciu	253	41	for	for	IN
cord-016523-pznw2ciu	253	42	the	the	DT
cord-016523-pznw2ciu	253	43	damage	damage	NN
cord-016523-pznw2ciu	253	44	of	of	IN
cord-016523-pznw2ciu	253	45	the	the	DT
cord-016523-pznw2ciu	253	46	lung	lung	NN
cord-016523-pznw2ciu	253	47	epithelium	epithelium	NN
cord-016523-pznw2ciu	253	48	in	in	IN
cord-016523-pznw2ciu	253	49	ARDS	ARDS	NNP
cord-016523-pznw2ciu	253	50	[	[	-LRB-
cord-016523-pznw2ciu	253	51	168	168	CD
cord-016523-pznw2ciu	253	52	]	]	-RRB-
cord-016523-pznw2ciu	253	53	.	.	.
cord-016523-pznw2ciu	254	1	Of	of	IN
cord-016523-pznw2ciu	254	2	note	note	VB
cord-016523-pznw2ciu	254	3	,	,	,
cord-016523-pznw2ciu	254	4	in	in	IN
cord-016523-pznw2ciu	254	5	ARDS	ARDS	NNP
cord-016523-pznw2ciu	254	6	BALs	BALs	NNP
cord-016523-pznw2ciu	254	7	,	,	,
cord-016523-pznw2ciu	254	8	additional	additional	JJ
cord-016523-pznw2ciu	254	9	oxidation	oxidation	NN
cord-016523-pznw2ciu	254	10	occurs	occur	VBZ
cord-016523-pznw2ciu	254	11	at	at	IN
cord-016523-pznw2ciu	254	12	methionine	methionine	NN
cord-016523-pznw2ciu	254	13	121	121	CD
cord-016523-pznw2ciu	255	1	(	(	-LRB-
cord-016523-pznw2ciu	255	2	Fig	Fig	NNP
cord-016523-pznw2ciu	255	3	.	.	.
cord-016523-pznw2ciu	256	1	9	9	CD
cord-016523-pznw2ciu	256	2	.5	.5	CD
cord-016523-pznw2ciu	256	3	)	)	-RRB-
cord-016523-pznw2ciu	256	4	,	,	,
cord-016523-pznw2ciu	256	5	which	which	WDT
cord-016523-pznw2ciu	256	6	in	in	IN
cord-016523-pznw2ciu	256	7	turn	turn	NN
cord-016523-pznw2ciu	256	8	prevents	prevent	VBZ
cord-016523-pznw2ciu	256	9	the	the	DT
cord-016523-pznw2ciu	256	10	processing	processing	NN
cord-016523-pznw2ciu	256	11	of	of	IN
cord-016523-pznw2ciu	256	12	CD95L	cd95l	NN
cord-016523-pznw2ciu	256	13	by	by	IN
cord-016523-pznw2ciu	256	14	MMP7	MMP7	NNP
cord-016523-pznw2ciu	256	15	,	,	,
cord-016523-pznw2ciu	256	16	and	and	CC
cord-016523-pznw2ciu	256	17	explains	explain	VBZ
cord-016523-pznw2ciu	256	18	why	why	WRB
cord-016523-pznw2ciu	256	19	this	this	DT
cord-016523-pznw2ciu	256	20	cytotoxic	cytotoxic	JJ
cord-016523-pznw2ciu	256	21	ligand	ligand	NN
cord-016523-pznw2ciu	256	22	keeps	keep	VBZ
cord-016523-pznw2ciu	256	23	its	-PRON-	PRP$
cord-016523-pznw2ciu	256	24	stalk	stalk	NN
cord-016523-pznw2ciu	256	25	region	region	NN
cord-016523-pznw2ciu	256	26	[	[	-LRB-
cord-016523-pznw2ciu	256	27	168	168	CD
cord-016523-pznw2ciu	256	28	]	]	-RRB-
cord-016523-pznw2ciu	256	29	.	.	.
cord-016523-pznw2ciu	257	1	Nonetheless	nonetheless	RB
cord-016523-pznw2ciu	257	2	,	,	,
cord-016523-pznw2ciu	257	3	preservation	preservation	NN
cord-016523-pznw2ciu	257	4	of	of	IN
cord-016523-pznw2ciu	257	5	this	this	DT
cord-016523-pznw2ciu	257	6	region	region	NN
cord-016523-pznw2ciu	257	7	in	in	IN
cord-016523-pznw2ciu	257	8	soluble	soluble	JJ
cord-016523-pznw2ciu	257	9	CD95L	cd95l	NN
cord-016523-pznw2ciu	257	10	raises	raise	VBZ
cord-016523-pznw2ciu	257	11	the	the	DT
cord-016523-pznw2ciu	257	12	question	question	NN
cord-016523-pznw2ciu	257	13	that	that	IN
cord-016523-pznw2ciu	257	14	whether	whether	IN
cord-016523-pznw2ciu	257	15	an	an	DT
cord-016523-pznw2ciu	257	16	unidentifi	unidentifi	NN
cord-016523-pznw2ciu	257	17	ed	ed	NNP
cord-016523-pznw2ciu	257	18	MMP7independent	MMP7independent	NNP
cord-016523-pznw2ciu	257	19	cleavage	cleavage	NN
cord-016523-pznw2ciu	257	20	site	site	NN
cord-016523-pznw2ciu	257	21	exists	exist	VBZ
cord-016523-pznw2ciu	257	22	in	in	IN
cord-016523-pznw2ciu	257	23	the	the	DT
cord-016523-pznw2ciu	257	24	juxtamembrane	juxtamembrane	NNP
cord-016523-pznw2ciu	257	25	region	region	NN
cord-016523-pznw2ciu	257	26	of	of	IN
cord-016523-pznw2ciu	257	27	CD95L	CD95L	NNP
cord-016523-pznw2ciu	257	28	,	,	,
cord-016523-pznw2ciu	257	29	near	near	IN
cord-016523-pznw2ciu	257	30	the	the	DT
cord-016523-pznw2ciu	257	31	plasma	plasma	NN
cord-016523-pznw2ciu	257	32	membrane	membrane	NN
cord-016523-pznw2ciu	257	33	,	,	,
cord-016523-pznw2ciu	257	34	or	or	CC
cord-016523-pznw2ciu	257	35	the	the	DT
cord-016523-pznw2ciu	257	36	ligand	ligand	NN
cord-016523-pznw2ciu	257	37	detected	detect	VBN
cord-016523-pznw2ciu	257	38	in	in	IN
cord-016523-pznw2ciu	257	39	ARDS	ARDS	NNP
cord-016523-pznw2ciu	257	40	patients	patient	NNS
cord-016523-pznw2ciu	257	41	corresponds	correspond	VBZ
cord-016523-pznw2ciu	257	42	to	to	IN
cord-016523-pznw2ciu	257	43	the	the	DT
cord-016523-pznw2ciu	257	44	full	full	JJ
cord-016523-pznw2ciu	257	45	-	-	HYPH
cord-016523-pznw2ciu	257	46	length	length	NN
cord-016523-pznw2ciu	257	47	CD95L	cd95l	NN
cord-016523-pznw2ciu	257	48	embedded	embed	VBN
cord-016523-pznw2ciu	257	49	in	in	IN
cord-016523-pznw2ciu	257	50	exosomes	exosomes	NNP
cord-016523-pznw2ciu	257	51	[	[	-LRB-
cord-016523-pznw2ciu	257	52	169	169	CD
cord-016523-pznw2ciu	257	53	,	,	,
cord-016523-pznw2ciu	257	54	170	170	CD
cord-016523-pznw2ciu	257	55	]	]	-RRB-
cord-016523-pznw2ciu	257	56	.	.	.
cord-016523-pznw2ciu	258	1	Indeed	indeed	RB
cord-016523-pznw2ciu	258	2	,	,	,
cord-016523-pznw2ciu	258	3	this	this	DT
cord-016523-pznw2ciu	258	4	peculiar	peculiar	JJ
cord-016523-pznw2ciu	258	5	exosome	exosome	NN
cord-016523-pznw2ciu	258	6	-	-	HYPH
cord-016523-pznw2ciu	258	7	bound	bind	VBN
cord-016523-pznw2ciu	258	8	CD95L	cd95l	NN
cord-016523-pznw2ciu	258	9	can	can	MD
cord-016523-pznw2ciu	258	10	be	be	VB
cord-016523-pznw2ciu	258	11	expressed	express	VBN
cord-016523-pznw2ciu	258	12	by	by	IN
cord-016523-pznw2ciu	258	13	human	human	JJ
cord-016523-pznw2ciu	258	14	prostate	prostate	NN
cord-016523-pznw2ciu	258	15	cancer	cancer	NN
cord-016523-pznw2ciu	258	16	cells	cell	NNS
cord-016523-pznw2ciu	258	17	(	(	-LRB-
cord-016523-pznw2ciu	258	18	i.e.	i.e.	FW
cord-016523-pznw2ciu	258	19	,	,	,
cord-016523-pznw2ciu	258	20	LNCaP	lncap	ADD
cord-016523-pznw2ciu	258	21	)	)	-RRB-
cord-016523-pznw2ciu	258	22	,	,	,
cord-016523-pznw2ciu	258	23	and	and	CC
cord-016523-pznw2ciu	258	24	evokes	evoke	VBZ
cord-016523-pznw2ciu	258	25	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	258	26	in	in	IN
cord-016523-pznw2ciu	258	27	activated	activate	VBN
cord-016523-pznw2ciu	258	28	T	t	NN
cord-016523-pznw2ciu	258	29	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	258	30	[	[	-LRB-
cord-016523-pznw2ciu	258	31	171	171	CD
cord-016523-pznw2ciu	258	32	]	]	-RRB-
cord-016523-pznw2ciu	258	33	.	.	.
cord-016523-pznw2ciu	259	1	Overall	overall	RB
cord-016523-pznw2ciu	259	2	,	,	,
cord-016523-pznw2ciu	259	3	these	these	DT
cord-016523-pznw2ciu	259	4	fi	fi	NNP
cord-016523-pznw2ciu	259	5	ndings	nding	NNS
cord-016523-pznw2ciu	259	6	emphasize	emphasize	VBP
cord-016523-pznw2ciu	259	7	that	that	IN
cord-016523-pznw2ciu	259	8	it	-PRON-	PRP
cord-016523-pznw2ciu	259	9	will	will	MD
cord-016523-pznw2ciu	259	10	be	be	VB
cord-016523-pznw2ciu	259	11	of	of	IN
cord-016523-pznw2ciu	259	12	great	great	JJ
cord-016523-pznw2ciu	259	13	interest	interest	NN
cord-016523-pznw2ciu	259	14	in	in	IN
cord-016523-pznw2ciu	259	15	the	the	DT
cord-016523-pznw2ciu	259	16	future	future	NN
cord-016523-pznw2ciu	259	17	to	to	TO
cord-016523-pznw2ciu	259	18	fi	fi	VB
cord-016523-pznw2ciu	259	19	nely	nely	RB
cord-016523-pznw2ciu	259	20	characterize	characterize	VB
cord-016523-pznw2ciu	259	21	the	the	DT
cord-016523-pznw2ciu	259	22	quaternary	quaternary	JJ
cord-016523-pznw2ciu	259	23	structure	structure	NN
cord-016523-pznw2ciu	259	24	of	of	IN
cord-016523-pznw2ciu	259	25	the	the	DT
cord-016523-pznw2ciu	259	26	naturally	naturally	RB
cord-016523-pznw2ciu	259	27	processed	process	VBN
cord-016523-pznw2ciu	259	28	CD95L	CD95L	NNS
cord-016523-pznw2ciu	259	29	from	from	IN
cord-016523-pznw2ciu	259	30	the	the	DT
cord-016523-pznw2ciu	259	31	sera	sera	NNP
cord-016523-pznw2ciu	259	32	of	of	IN
cord-016523-pznw2ciu	259	33	patients	patient	NNS
cord-016523-pznw2ciu	259	34	affected	affect	VBN
cord-016523-pznw2ciu	259	35	by	by	IN
cord-016523-pznw2ciu	259	36	cancers	cancer	NNS
cord-016523-pznw2ciu	259	37	or	or	CC
cord-016523-pznw2ciu	259	38	chronic	chronic	JJ
cord-016523-pznw2ciu	259	39	/	/	SYM
cord-016523-pznw2ciu	259	40	acute	acute	JJ
cord-016523-pznw2ciu	259	41	infl	infl	NNP
cord-016523-pznw2ciu	259	42	ammatory	ammatory	NNP
cord-016523-pznw2ciu	259	43	disorders	disorder	NNS
cord-016523-pznw2ciu	259	44	,	,	,
cord-016523-pznw2ciu	259	45	to	to	TO
cord-016523-pznw2ciu	259	46	better	better	RB
cord-016523-pznw2ciu	259	47	understand	understand	VB
cord-016523-pznw2ciu	259	48	the	the	DT
cord-016523-pznw2ciu	259	49	molecular	molecular	JJ
cord-016523-pznw2ciu	259	50	mechanisms	mechanism	NNS
cord-016523-pznw2ciu	259	51	implemented	implement	VBN
cord-016523-pznw2ciu	259	52	by	by	IN
cord-016523-pznw2ciu	259	53	this	this	DT
cord-016523-pznw2ciu	259	54	ligand	ligand	NN
cord-016523-pznw2ciu	259	55	and	and	CC
cord-016523-pznw2ciu	259	56	thus	thus	RB
cord-016523-pznw2ciu	259	57	predict	predict	VB
cord-016523-pznw2ciu	259	58	its	-PRON-	PRP$
cord-016523-pznw2ciu	259	59	subsequent	subsequent	JJ
cord-016523-pznw2ciu	259	60	biological	biological	JJ
cord-016523-pznw2ciu	259	61	functions	function	NNS
cord-016523-pznw2ciu	259	62	.	.	.
cord-016523-pznw2ciu	260	1	Apoptosis	apoptosis	NN
cord-016523-pznw2ciu	260	2	is	be	VBZ
cord-016523-pznw2ciu	260	3	a	a	DT
cord-016523-pznw2ciu	260	4	fundamental	fundamental	JJ
cord-016523-pznw2ciu	260	5	process	process	NN
cord-016523-pznw2ciu	260	6	contributing	contribute	VBG
cord-016523-pznw2ciu	260	7	to	to	IN
cord-016523-pznw2ciu	260	8	tissue	tissue	NN
cord-016523-pznw2ciu	260	9	homeostasis	homeostasis	NN
cord-016523-pznw2ciu	260	10	,	,	,
cord-016523-pznw2ciu	260	11	immune	immune	JJ
cord-016523-pznw2ciu	260	12	response	response	NN
cord-016523-pznw2ciu	260	13	,	,	,
cord-016523-pznw2ciu	260	14	and	and	CC
cord-016523-pznw2ciu	260	15	development	development	NN
cord-016523-pznw2ciu	260	16	.	.	.
cord-016523-pznw2ciu	261	1	CD95	CD95	NNP
cord-016523-pznw2ciu	261	2	,	,	,
cord-016523-pznw2ciu	261	3	also	also	RB
cord-016523-pznw2ciu	261	4	called	call	VBN
cord-016523-pznw2ciu	261	5	Fas	Fas	NNP
cord-016523-pznw2ciu	261	6	,	,	,
cord-016523-pznw2ciu	261	7	is	be	VBZ
cord-016523-pznw2ciu	261	8	a	a	DT
cord-016523-pznw2ciu	261	9	member	member	NN
cord-016523-pznw2ciu	261	10	of	of	IN
cord-016523-pznw2ciu	261	11	the	the	DT
cord-016523-pznw2ciu	261	12	tumor	tumor	NN
cord-016523-pznw2ciu	261	13	necrosis	necrosis	NN
cord-016523-pznw2ciu	261	14	factor	factor	NN
cord-016523-pznw2ciu	261	15	receptor	receptor	NN
cord-016523-pznw2ciu	261	16	(	(	-LRB-
cord-016523-pznw2ciu	261	17	TNF	TNF	NNP
cord-016523-pznw2ciu	261	18	-	-	HYPH
cord-016523-pznw2ciu	261	19	R	R	NNP
cord-016523-pznw2ciu	261	20	)	)	-RRB-
cord-016523-pznw2ciu	261	21	superfamily	superfamily	NN
cord-016523-pznw2ciu	261	22	.	.	.
cord-016523-pznw2ciu	262	1	Its	-PRON-	PRP$
cord-016523-pznw2ciu	262	2	ligand	ligand	NN
cord-016523-pznw2ciu	262	3	,	,	,
cord-016523-pznw2ciu	262	4	CD95L	cd95l	NN
cord-016523-pznw2ciu	262	5	,	,	,
cord-016523-pznw2ciu	262	6	was	be	VBD
cord-016523-pznw2ciu	262	7	initially	initially	RB
cord-016523-pznw2ciu	262	8	detected	detect	VBN
cord-016523-pznw2ciu	262	9	at	at	IN
cord-016523-pznw2ciu	262	10	the	the	DT
cord-016523-pznw2ciu	262	11	plasma	plasma	NN
cord-016523-pznw2ciu	262	12	membrane	membrane	NN
cord-016523-pznw2ciu	262	13	of	of	IN
cord-016523-pznw2ciu	262	14	activated	activate	VBN
cord-016523-pznw2ciu	262	15	T	T	NNP
cord-016523-pznw2ciu	262	16	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	262	17	and	and	CC
cord-016523-pznw2ciu	262	18	natural	natural	JJ
cord-016523-pznw2ciu	262	19	killer	killer	NN
cord-016523-pznw2ciu	262	20	(	(	-LRB-
cord-016523-pznw2ciu	262	21	NK	NK	NNP
cord-016523-pznw2ciu	262	22	)	)	-RRB-
cord-016523-pznw2ciu	262	23	cells	cell	NNS
cord-016523-pznw2ciu	262	24	where	where	WRB
cord-016523-pznw2ciu	262	25	it	-PRON-	PRP
cord-016523-pznw2ciu	262	26	contributes	contribute	VBZ
cord-016523-pznw2ciu	262	27	to	to	IN
cord-016523-pznw2ciu	262	28	the	the	DT
cord-016523-pznw2ciu	262	29	elimination	elimination	NN
cord-016523-pznw2ciu	262	30	of	of	IN
cord-016523-pznw2ciu	262	31	transformed	transform	VBN
cord-016523-pznw2ciu	262	32	and	and	CC
cord-016523-pznw2ciu	262	33	infected	infected	JJ
cord-016523-pznw2ciu	262	34	cells	cell	NNS
cord-016523-pznw2ciu	262	35	.	.	.
cord-016523-pznw2ciu	263	1	Given	give	VBN
cord-016523-pznw2ciu	263	2	its	-PRON-	PRP$
cord-016523-pznw2ciu	263	3	implication	implication	NN
cord-016523-pznw2ciu	263	4	in	in	IN
cord-016523-pznw2ciu	263	5	immune	immune	JJ
cord-016523-pznw2ciu	263	6	homeostasis	homeostasis	NN
cord-016523-pznw2ciu	263	7	and	and	CC
cord-016523-pznw2ciu	263	8	immune	immune	JJ
cord-016523-pznw2ciu	263	9	surveillance	surveillance	NN
cord-016523-pznw2ciu	263	10	combined	combine	VBN
cord-016523-pznw2ciu	263	11	with	with	IN
cord-016523-pznw2ciu	263	12	the	the	DT
cord-016523-pznw2ciu	263	13	fact	fact	NN
cord-016523-pznw2ciu	263	14	that	that	IN
cord-016523-pznw2ciu	263	15	various	various	JJ
cord-016523-pznw2ciu	263	16	lineages	lineage	NNS
cord-016523-pznw2ciu	263	17	of	of	IN
cord-016523-pznw2ciu	263	18	malignant	malignant	JJ
cord-016523-pznw2ciu	263	19	cells	cell	NNS
cord-016523-pznw2ciu	263	20	exhibit	exhibit	VBP
cord-016523-pznw2ciu	263	21	loss	loss	NN
cord-016523-pznw2ciu	263	22	-	-	HYPH
cord-016523-pznw2ciu	263	23	of	of	IN
cord-016523-pznw2ciu	263	24	-	-	HYPH
cord-016523-pznw2ciu	263	25	function	function	NN
cord-016523-pznw2ciu	263	26	mutations	mutation	NNS
cord-016523-pznw2ciu	263	27	,	,	,
cord-016523-pznw2ciu	263	28	CD95	CD95	NNP
cord-016523-pznw2ciu	263	29	was	be	VBD
cord-016523-pznw2ciu	263	30	initially	initially	RB
cord-016523-pznw2ciu	263	31	classifi	classifi	NNP
cord-016523-pznw2ciu	263	32	ed	ed	NN
cord-016523-pznw2ciu	263	33	as	as	IN
cord-016523-pznw2ciu	263	34	a	a	DT
cord-016523-pznw2ciu	263	35	tumor	tumor	NN
cord-016523-pznw2ciu	263	36	suppressor	suppressor	NN
cord-016523-pznw2ciu	263	37	gene	gene	NN
cord-016523-pznw2ciu	263	38	.	.	.
cord-016523-pznw2ciu	264	1	Nonetheless	nonetheless	RB
cord-016523-pznw2ciu	264	2	,	,	,
cord-016523-pznw2ciu	264	3	in	in	IN
cord-016523-pznw2ciu	264	4	different	different	JJ
cord-016523-pznw2ciu	264	5	pathophysiological	pathophysiological	JJ
cord-016523-pznw2ciu	264	6	contexts	context	NNS
cord-016523-pznw2ciu	264	7	,	,	,
cord-016523-pznw2ciu	264	8	this	this	DT
cord-016523-pznw2ciu	264	9	receptor	receptor	NN
cord-016523-pznw2ciu	264	10	is	be	VBZ
cord-016523-pznw2ciu	264	11	able	able	JJ
cord-016523-pznw2ciu	264	12	to	to	TO
cord-016523-pznw2ciu	264	13	transmit	transmit	VB
cord-016523-pznw2ciu	264	14	non	non	JJ
cord-016523-pznw2ciu	264	15	-	-	JJ
cord-016523-pznw2ciu	264	16	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	264	17	signals	signal	NNS
cord-016523-pznw2ciu	264	18	and	and	CC
cord-016523-pznw2ciu	264	19	promote	promote	VB
cord-016523-pznw2ciu	264	20	infl	infl	NN
cord-016523-pznw2ciu	264	21	ammation	ammation	NN
cord-016523-pznw2ciu	264	22	and	and	CC
cord-016523-pznw2ciu	264	23	carcinogenesis	carcinogenesis	NN
cord-016523-pznw2ciu	264	24	.	.	.
cord-016523-pznw2ciu	265	1	Although	although	IN
cord-016523-pznw2ciu	265	2	the	the	DT
cord-016523-pznw2ciu	265	3	different	different	JJ
cord-016523-pznw2ciu	265	4	non	non	JJ
cord-016523-pznw2ciu	265	5	-	-	JJ
cord-016523-pznw2ciu	265	6	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	265	7	signaling	signal	VBG
cord-016523-pznw2ciu	265	8	pathways	pathway	NNS
cord-016523-pznw2ciu	265	9	(	(	-LRB-
cord-016523-pznw2ciu	265	10	NF	nf	NN
cord-016523-pznw2ciu	265	11	-	-	HYPH
cord-016523-pznw2ciu	265	12	κB	κB	NNP
cord-016523-pznw2ciu	265	13	,	,	,
cord-016523-pznw2ciu	265	14	MAPK	MAPK	NNP
cord-016523-pznw2ciu	265	15	,	,	,
cord-016523-pznw2ciu	265	16	and	and	CC
cord-016523-pznw2ciu	265	17	PI3	PI3	NNP
cord-016523-pznw2ciu	265	18	K	K	NNP
cord-016523-pznw2ciu	265	19	)	)	-RRB-
cord-016523-pznw2ciu	265	20	triggered	trigger	VBN
cord-016523-pznw2ciu	265	21	by	by	IN
cord-016523-pznw2ciu	265	22	CD95	CD95	NNP
cord-016523-pznw2ciu	265	23	are	be	VBP
cord-016523-pznw2ciu	265	24	known	know	VBN
cord-016523-pznw2ciu	265	25	,	,	,
cord-016523-pznw2ciu	265	26	the	the	DT
cord-016523-pznw2ciu	265	27	initial	initial	JJ
cord-016523-pznw2ciu	265	28	molecular	molecular	JJ
cord-016523-pznw2ciu	265	29	events	event	NNS
cord-016523-pznw2ciu	265	30	leading	lead	VBG
cord-016523-pznw2ciu	265	31	to	to	IN
cord-016523-pznw2ciu	265	32	these	these	DT
cord-016523-pznw2ciu	265	33	signals	signal	NNS
cord-016523-pznw2ciu	265	34	,	,	,
cord-016523-pznw2ciu	265	35	the	the	DT
cord-016523-pznw2ciu	265	36	mechanisms	mechanism	NNS
cord-016523-pznw2ciu	265	37	by	by	IN
cord-016523-pznw2ciu	265	38	which	which	WDT
cord-016523-pznw2ciu	265	39	the	the	DT
cord-016523-pznw2ciu	265	40	receptor	receptor	NN
cord-016523-pznw2ciu	265	41	switches	switch	VBZ
cord-016523-pznw2ciu	265	42	from	from	IN
cord-016523-pznw2ciu	265	43	an	an	DT
cord-016523-pznw2ciu	265	44	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	265	45	function	function	NN
cord-016523-pznw2ciu	265	46	to	to	IN
cord-016523-pznw2ciu	265	47	an	an	DT
cord-016523-pznw2ciu	265	48	infl	infl	NN
cord-016523-pznw2ciu	265	49	ammatory	ammatory	NN
cord-016523-pznw2ciu	265	50	role	role	NN
cord-016523-pznw2ciu	265	51	,	,	,
cord-016523-pznw2ciu	265	52	and	and	CC
cord-016523-pznw2ciu	265	53	,	,	,
cord-016523-pznw2ciu	265	54	more	more	RBR
cord-016523-pznw2ciu	265	55	importantly	importantly	RB
cord-016523-pznw2ciu	265	56	,	,	,
cord-016523-pznw2ciu	265	57	the	the	DT
cord-016523-pznw2ciu	265	58	biological	biological	JJ
cord-016523-pznw2ciu	265	59	functions	function	NNS
cord-016523-pznw2ciu	265	60	of	of	IN
cord-016523-pznw2ciu	265	61	these	these	DT
cord-016523-pznw2ciu	265	62	signals	signal	NNS
cord-016523-pznw2ciu	265	63	remain	remain	VBP
cord-016523-pznw2ciu	265	64	elusive	elusive	JJ
cord-016523-pznw2ciu	265	65	.	.	.
cord-016523-pznw2ciu	266	1	Apoptosis	apoptosis	NN
cord-016523-pznw2ciu	266	2	:	:	:
cord-016523-pznw2ciu	266	3	a	a	DT
cord-016523-pznw2ciu	266	4	basic	basic	JJ
cord-016523-pznw2ciu	266	5	biological	biological	JJ
cord-016523-pznw2ciu	266	6	phenomenon	phenomenon	NN
cord-016523-pznw2ciu	266	7	with	with	IN
cord-016523-pznw2ciu	266	8	wide	wide	RB
cord-016523-pznw2ciu	266	9	-	-	HYPH
cord-016523-pznw2ciu	266	10	ranging	range	VBG
cord-016523-pznw2ciu	266	11	implications	implication	NNS
cord-016523-pznw2ciu	266	12	in	in	IN
cord-016523-pznw2ciu	266	13	tissue	tissue	NN
cord-016523-pznw2ciu	266	14	kinetics	kinetics	NNP
cord-016523-pznw2ciu	266	15	Induction	Induction	NNP
cord-016523-pznw2ciu	266	16	of	of	IN
cord-016523-pznw2ciu	266	17	TNF	TNF	NNP
cord-016523-pznw2ciu	266	18	receptor	receptor	NN
cord-016523-pznw2ciu	266	19	I	I	NNP
cord-016523-pznw2ciu	266	20	-	-	HYPH
cord-016523-pznw2ciu	266	21	mediated	mediate	VBN
cord-016523-pznw2ciu	266	22	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	266	23	via	via	IN
cord-016523-pznw2ciu	266	24	two	two	CD
cord-016523-pznw2ciu	266	25	sequential	sequential	JJ
cord-016523-pznw2ciu	266	26	signaling	signal	VBG
cord-016523-pznw2ciu	266	27	complexes	complex	NNS
cord-016523-pznw2ciu	266	28	Apoptosis	Apoptosis	NNP
cord-016523-pznw2ciu	266	29	in	in	IN
cord-016523-pznw2ciu	266	30	Alzheimer	Alzheimer	NNP
cord-016523-pznw2ciu	266	31	's	's	POS
cord-016523-pznw2ciu	266	32	disease	disease	NN
cord-016523-pznw2ciu	266	33	-an	-an	CD
cord-016523-pznw2ciu	266	34	update	update	NN
cord-016523-pznw2ciu	266	35	Apoptosis	Apoptosis	NNP
cord-016523-pznw2ciu	266	36	in	in	IN
cord-016523-pznw2ciu	266	37	Parkinson	Parkinson	NNP
cord-016523-pznw2ciu	266	38	's	's	POS
cord-016523-pznw2ciu	266	39	disease	disease	NN
cord-016523-pznw2ciu	266	40	:	:	:
cord-016523-pznw2ciu	266	41	signals	signal	NNS
cord-016523-pznw2ciu	266	42	for	for	IN
cord-016523-pznw2ciu	266	43	neuronal	neuronal	JJ
cord-016523-pznw2ciu	266	44	degradation	degradation	NN
cord-016523-pznw2ciu	267	1	Human	Human	NNP
cord-016523-pznw2ciu	267	2	ICE	ICE	NNP
cord-016523-pznw2ciu	267	3	/	/	SYM
cord-016523-pznw2ciu	267	4	CED-3	CED-3	NNP
cord-016523-pznw2ciu	267	5	protease	protease	NN
cord-016523-pznw2ciu	267	6	nomenclature	nomenclature	NN
cord-016523-pznw2ciu	268	1	The	the	DT
cord-016523-pznw2ciu	268	2	biochemistry	biochemistry	NN
cord-016523-pznw2ciu	268	3	of	of	IN
cord-016523-pznw2ciu	268	4	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	269	1	A	a	DT
cord-016523-pznw2ciu	269	2	novel	novel	JJ
cord-016523-pznw2ciu	269	3	protein	protein	NN
cord-016523-pznw2ciu	269	4	that	that	WDT
cord-016523-pznw2ciu	269	5	interacts	interact	VBZ
cord-016523-pznw2ciu	269	6	with	with	IN
cord-016523-pznw2ciu	269	7	the	the	DT
cord-016523-pznw2ciu	269	8	death	death	NN
cord-016523-pznw2ciu	269	9	domain	domain	NN
cord-016523-pznw2ciu	269	10	of	of	IN
cord-016523-pznw2ciu	269	11	Fas	Fas	NNP
cord-016523-pznw2ciu	269	12	/	/	SYM
cord-016523-pznw2ciu	269	13	APO1	APO1	NNP
cord-016523-pznw2ciu	269	14	contains	contain	VBZ
cord-016523-pznw2ciu	269	15	a	a	DT
cord-016523-pznw2ciu	269	16	sequence	sequence	NN
cord-016523-pznw2ciu	269	17	motif	motif	NN
cord-016523-pznw2ciu	269	18	related	relate	VBN
cord-016523-pznw2ciu	269	19	to	to	IN
cord-016523-pznw2ciu	269	20	the	the	DT
cord-016523-pznw2ciu	269	21	death	death	NN
cord-016523-pznw2ciu	269	22	domain	domain	NN
cord-016523-pznw2ciu	269	23	FADD	FADD	NNP
cord-016523-pznw2ciu	269	24	,	,	,
cord-016523-pznw2ciu	269	25	a	a	DT
cord-016523-pznw2ciu	269	26	novel	novel	JJ
cord-016523-pznw2ciu	269	27	death	death	NN
cord-016523-pznw2ciu	269	28	domaincontaining	domaincontaining	NN
cord-016523-pznw2ciu	269	29	protein	protein	NN
cord-016523-pznw2ciu	269	30	,	,	,
cord-016523-pznw2ciu	269	31	interacts	interact	VBZ
cord-016523-pznw2ciu	269	32	with	with	IN
cord-016523-pznw2ciu	269	33	the	the	DT
cord-016523-pznw2ciu	269	34	death	death	NN
cord-016523-pznw2ciu	269	35	domain	domain	NN
cord-016523-pznw2ciu	269	36	of	of	IN
cord-016523-pznw2ciu	269	37	Fas	Fas	NNP
cord-016523-pznw2ciu	269	38	and	and	CC
cord-016523-pznw2ciu	269	39	initiates	initiate	VBZ
cord-016523-pznw2ciu	269	40	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	269	41	The	the	DT
cord-016523-pznw2ciu	269	42	TNF	TNF	NNP
cord-016523-pznw2ciu	269	43	receptor	receptor	NN
cord-016523-pznw2ciu	269	44	1-associated	1-associated	CD
cord-016523-pznw2ciu	269	45	protein	protein	NN
cord-016523-pznw2ciu	269	46	TRADD	TRADD	NNP
cord-016523-pznw2ciu	269	47	signals	signal	VBZ
cord-016523-pznw2ciu	269	48	cell	cell	NN
cord-016523-pznw2ciu	269	49	death	death	NN
cord-016523-pznw2ciu	269	50	and	and	CC
cord-016523-pznw2ciu	269	51	NF	nf	NN
cord-016523-pznw2ciu	269	52	-	-	HYPH
cord-016523-pznw2ciu	269	53	kappa	kappa	NN
cord-016523-pznw2ciu	269	54	B	B	NNP
cord-016523-pznw2ciu	269	55	activation	activation	NN
cord-016523-pznw2ciu	269	56	Cytotoxicity	Cytotoxicity	NNP
cord-016523-pznw2ciu	269	57	-	-	HYPH
cord-016523-pznw2ciu	269	58	dependent	dependent	JJ
cord-016523-pznw2ciu	269	59	APO-1	APO-1	NNP
cord-016523-pznw2ciu	270	1	(	(	-LRB-
cord-016523-pznw2ciu	270	2	Fas	Fas	NNP
cord-016523-pznw2ciu	270	3	/	/	SYM
cord-016523-pznw2ciu	270	4	CD95)-associated	CD95)-associated	NNP
cord-016523-pznw2ciu	270	5	proteins	protein	NNS
cord-016523-pznw2ciu	270	6	form	form	VBP
cord-016523-pznw2ciu	270	7	a	a	DT
cord-016523-pznw2ciu	270	8	deathinducing	deathinducing	NN
cord-016523-pznw2ciu	270	9	signaling	signal	VBG
cord-016523-pznw2ciu	270	10	complex	complex	NN
cord-016523-pznw2ciu	270	11	(	(	-LRB-
cord-016523-pznw2ciu	270	12	DISC	disc	NN
cord-016523-pznw2ciu	270	13	)	)	-RRB-
cord-016523-pznw2ciu	270	14	with	with	IN
cord-016523-pznw2ciu	270	15	the	the	DT
cord-016523-pznw2ciu	270	16	receptor	receptor	NN
cord-016523-pznw2ciu	270	17	Cytochrome	Cytochrome	NNP
cord-016523-pznw2ciu	270	18	c	c	NN
cord-016523-pznw2ciu	270	19	and	and	CC
cord-016523-pznw2ciu	270	20	dATP	datp	JJ
cord-016523-pznw2ciu	270	21	-	-	HYPH
cord-016523-pznw2ciu	270	22	dependent	dependent	JJ
cord-016523-pznw2ciu	270	23	formation	formation	NN
cord-016523-pznw2ciu	270	24	of	of	IN
cord-016523-pznw2ciu	270	25	Apaf-1	Apaf-1	NNP
cord-016523-pznw2ciu	270	26	/	/	SYM
cord-016523-pznw2ciu	270	27	caspase-9	caspase-9	NNP
cord-016523-pznw2ciu	270	28	complex	complex	NN
cord-016523-pznw2ciu	270	29	initiates	initiate	VBZ
cord-016523-pznw2ciu	270	30	an	an	DT
cord-016523-pznw2ciu	270	31	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	270	32	protease	protease	NN
cord-016523-pznw2ciu	270	33	cascade	cascade	VB
cord-016523-pznw2ciu	270	34	The	the	DT
cord-016523-pznw2ciu	270	35	polypeptide	polypeptide	NN
cord-016523-pznw2ciu	270	36	encoded	encode	VBN
cord-016523-pznw2ciu	270	37	by	by	IN
cord-016523-pznw2ciu	270	38	the	the	DT
cord-016523-pznw2ciu	270	39	cDNA	cdna	NN
cord-016523-pznw2ciu	270	40	for	for	IN
cord-016523-pznw2ciu	270	41	human	human	JJ
cord-016523-pznw2ciu	270	42	cell	cell	NN
cord-016523-pznw2ciu	270	43	surface	surface	NN
cord-016523-pznw2ciu	270	44	antigen	antigen	NN
cord-016523-pznw2ciu	270	45	Fas	Fas	NNP
cord-016523-pznw2ciu	270	46	can	can	MD
cord-016523-pznw2ciu	270	47	mediate	mediate	VB
cord-016523-pznw2ciu	270	48	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	270	49	Molecular	molecular	JJ
cord-016523-pznw2ciu	270	50	cloning	cloning	NN
cord-016523-pznw2ciu	270	51	and	and	CC
cord-016523-pznw2ciu	270	52	expression	expression	NN
cord-016523-pznw2ciu	270	53	of	of	IN
cord-016523-pznw2ciu	270	54	the	the	DT
cord-016523-pznw2ciu	270	55	human	human	JJ
cord-016523-pznw2ciu	270	56	55	55	CD
cord-016523-pznw2ciu	270	57	kd	kd	NNP
cord-016523-pznw2ciu	270	58	tumor	tumor	NN
cord-016523-pznw2ciu	270	59	necrosis	necrosis	NN
cord-016523-pznw2ciu	270	60	factor	factor	NN
cord-016523-pznw2ciu	270	61	receptor	receptor	NN
cord-016523-pznw2ciu	271	1	The	the	DT
cord-016523-pznw2ciu	271	2	receptor	receptor	NN
cord-016523-pznw2ciu	271	3	for	for	IN
cord-016523-pznw2ciu	271	4	the	the	DT
cord-016523-pznw2ciu	271	5	cytotoxic	cytotoxic	JJ
cord-016523-pznw2ciu	271	6	ligand	ligand	NN
cord-016523-pznw2ciu	271	7	TRAIL	TRAIL	NNP
cord-016523-pznw2ciu	271	8	TRAIL	TRAIL	NNP
cord-016523-pznw2ciu	271	9	-	-	HYPH
cord-016523-pznw2ciu	271	10	R2	R2	NNP
cord-016523-pznw2ciu	271	11	:	:	:
cord-016523-pznw2ciu	271	12	a	a	DT
cord-016523-pznw2ciu	271	13	novel	novel	JJ
cord-016523-pznw2ciu	271	14	apoptosismediating	apoptosismediating	NN
cord-016523-pznw2ciu	271	15	receptor	receptor	NN
cord-016523-pznw2ciu	271	16	for	for	IN
cord-016523-pznw2ciu	271	17	TRAIL	TRAIL	NNP
cord-016523-pznw2ciu	271	18	Identifi	Identifi	NNP
cord-016523-pznw2ciu	271	19	cation	cation	NN
cord-016523-pznw2ciu	271	20	and	and	CC
cord-016523-pznw2ciu	271	21	functional	functional	JJ
cord-016523-pznw2ciu	271	22	characterization	characterization	NN
cord-016523-pznw2ciu	271	23	of	of	IN
cord-016523-pznw2ciu	271	24	DR6	DR6	NNP
cord-016523-pznw2ciu	271	25	,	,	,
cord-016523-pznw2ciu	271	26	a	a	DT
cord-016523-pznw2ciu	271	27	novel	novel	JJ
cord-016523-pznw2ciu	271	28	death	death	NN
cord-016523-pznw2ciu	271	29	domain	domain	NN
cord-016523-pznw2ciu	271	30	-	-	HYPH
cord-016523-pznw2ciu	271	31	containing	contain	VBG
cord-016523-pznw2ciu	271	32	TNF	TNF	NNP
cord-016523-pznw2ciu	271	33	receptor	receptor	NN
cord-016523-pznw2ciu	271	34	Fas	Fas	NNP
cord-016523-pznw2ciu	271	35	transduces	transduce	NNS
cord-016523-pznw2ciu	271	36	activation	activation	NN
cord-016523-pznw2ciu	271	37	signals	signal	NNS
cord-016523-pznw2ciu	271	38	in	in	IN
cord-016523-pznw2ciu	271	39	normal	normal	JJ
cord-016523-pznw2ciu	271	40	human	human	JJ
cord-016523-pznw2ciu	271	41	T	t	NN
cord-016523-pznw2ciu	271	42	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	272	1	Divergent	divergent	JJ
cord-016523-pznw2ciu	272	2	signalling	signal	VBG
cord-016523-pznw2ciu	272	3	via	via	IN
cord-016523-pznw2ciu	272	4	APO-1	APO-1	NNP
cord-016523-pznw2ciu	272	5	/	/	SYM
cord-016523-pznw2ciu	272	6	Fas	Fas	NNP
cord-016523-pznw2ciu	272	7	and	and	CC
cord-016523-pznw2ciu	272	8	the	the	DT
cord-016523-pznw2ciu	272	9	TNF	TNF	NNP
cord-016523-pznw2ciu	272	10	receptor	receptor	NN
cord-016523-pznw2ciu	272	11	,	,	,
cord-016523-pznw2ciu	272	12	two	two	CD
cord-016523-pznw2ciu	272	13	homologous	homologous	JJ
cord-016523-pznw2ciu	272	14	molecules	molecule	NNS
cord-016523-pznw2ciu	272	15	involved	involve	VBN
cord-016523-pznw2ciu	272	16	in	in	IN
cord-016523-pznw2ciu	272	17	physiological	physiological	JJ
cord-016523-pznw2ciu	272	18	cell	cell	NN
cord-016523-pznw2ciu	272	19	death	death	NN
cord-016523-pznw2ciu	273	1	The	the	DT
cord-016523-pznw2ciu	273	2	TNF	TNF	NNP
cord-016523-pznw2ciu	273	3	receptor	receptor	NN
cord-016523-pznw2ciu	273	4	superfamily	superfamily	NN
cord-016523-pznw2ciu	273	5	of	of	IN
cord-016523-pznw2ciu	273	6	cellular	cellular	JJ
cord-016523-pznw2ciu	273	7	and	and	CC
cord-016523-pznw2ciu	273	8	viral	viral	JJ
cord-016523-pznw2ciu	273	9	proteins	protein	NNS
cord-016523-pznw2ciu	273	10	:	:	:
cord-016523-pznw2ciu	273	11	activation	activation	NN
cord-016523-pznw2ciu	273	12	,	,	,
cord-016523-pznw2ciu	273	13	costimulation	costimulation	NN
cord-016523-pznw2ciu	273	14	,	,	,
cord-016523-pznw2ciu	273	15	and	and	CC
cord-016523-pznw2ciu	273	16	death	death	NN
cord-016523-pznw2ciu	274	1	The	the	DT
cord-016523-pznw2ciu	274	2	TNF	TNF	NNP
cord-016523-pznw2ciu	274	3	and	and	CC
cord-016523-pznw2ciu	274	4	TNF	TNF	NNP
cord-016523-pznw2ciu	274	5	receptor	receptor	NN
cord-016523-pznw2ciu	274	6	superfamilies	superfamily	NNS
cord-016523-pznw2ciu	274	7	:	:	:
cord-016523-pznw2ciu	274	8	integrating	integrate	VBG
cord-016523-pznw2ciu	274	9	mammalian	mammalian	JJ
cord-016523-pznw2ciu	274	10	biology	biology	NN
cord-016523-pznw2ciu	275	1	The	the	DT
cord-016523-pznw2ciu	275	2	molecular	molecular	JJ
cord-016523-pznw2ciu	275	3	architecture	architecture	NN
cord-016523-pznw2ciu	275	4	of	of	IN
cord-016523-pznw2ciu	275	5	the	the	DT
cord-016523-pznw2ciu	275	6	TNF	TNF	NNP
cord-016523-pznw2ciu	275	7	superfamily	superfamily	NN
cord-016523-pznw2ciu	275	8	Precise	precise	JJ
cord-016523-pznw2ciu	275	9	mapping	mapping	NN
cord-016523-pznw2ciu	275	10	of	of	IN
cord-016523-pznw2ciu	275	11	the	the	DT
cord-016523-pznw2ciu	275	12	CD95	CD95	NNP
cord-016523-pznw2ciu	275	13	preligand	preligand	NN
cord-016523-pznw2ciu	275	14	assembly	assembly	NN
cord-016523-pznw2ciu	275	15	domain	domain	NN
cord-016523-pznw2ciu	275	16	Identifi	Identifi	NNP
cord-016523-pznw2ciu	275	17	cation	cation	NN
cord-016523-pznw2ciu	275	18	and	and	CC
cord-016523-pznw2ciu	275	19	characterization	characterization	NN
cord-016523-pznw2ciu	275	20	of	of	IN
cord-016523-pznw2ciu	275	21	a	a	DT
cord-016523-pznw2ciu	275	22	ligand	ligand	NN
cord-016523-pznw2ciu	275	23	-	-	HYPH
cord-016523-pznw2ciu	275	24	independent	independent	JJ
cord-016523-pznw2ciu	275	25	oligomerization	oligomerization	NN
cord-016523-pznw2ciu	275	26	domain	domain	NN
cord-016523-pznw2ciu	275	27	in	in	IN
cord-016523-pznw2ciu	275	28	the	the	DT
cord-016523-pznw2ciu	275	29	extracellular	extracellular	JJ
cord-016523-pznw2ciu	275	30	region	region	NN
cord-016523-pznw2ciu	275	31	of	of	IN
cord-016523-pznw2ciu	275	32	the	the	DT
cord-016523-pznw2ciu	275	33	CD95	CD95	NNP
cord-016523-pznw2ciu	275	34	death	death	NN
cord-016523-pznw2ciu	275	35	receptor	receptor	NN
cord-016523-pznw2ciu	276	1	Fas	Fas	NNP
cord-016523-pznw2ciu	276	2	preassociation	preassociation	NN
cord-016523-pznw2ciu	276	3	required	require	VBN
cord-016523-pznw2ciu	276	4	for	for	IN
cord-016523-pznw2ciu	276	5	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	276	6	signaling	signal	VBG
cord-016523-pznw2ciu	276	7	and	and	CC
cord-016523-pznw2ciu	276	8	dominant	dominant	JJ
cord-016523-pznw2ciu	276	9	inhibition	inhibition	NN
cord-016523-pznw2ciu	276	10	by	by	IN
cord-016523-pznw2ciu	276	11	pathogenic	pathogenic	JJ
cord-016523-pznw2ciu	276	12	mutations	mutation	NNS
cord-016523-pznw2ciu	277	1	A	a	DT
cord-016523-pznw2ciu	277	2	novel	novel	JJ
cord-016523-pznw2ciu	277	3	protein	protein	NN
cord-016523-pznw2ciu	277	4	domain	domain	NN
cord-016523-pznw2ciu	277	5	required	require	VBN
cord-016523-pznw2ciu	277	6	for	for	IN
cord-016523-pznw2ciu	277	7	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	277	8	.	.	.
cord-016523-pznw2ciu	278	1	Mutational	mutational	JJ
cord-016523-pznw2ciu	278	2	analysis	analysis	NN
cord-016523-pznw2ciu	278	3	of	of	IN
cord-016523-pznw2ciu	278	4	human	human	JJ
cord-016523-pznw2ciu	278	5	Fas	Fas	NNP
cord-016523-pznw2ciu	278	6	antigen	antigen	NN
cord-016523-pznw2ciu	278	7	A	a	DT
cord-016523-pznw2ciu	278	8	novel	novel	JJ
cord-016523-pznw2ciu	278	9	domain	domain	NN
cord-016523-pznw2ciu	278	10	within	within	IN
cord-016523-pznw2ciu	278	11	the	the	DT
cord-016523-pznw2ciu	278	12	55	55	CD
cord-016523-pznw2ciu	278	13	kd	kd	NNP
cord-016523-pznw2ciu	278	14	TNF	TNF	NNP
cord-016523-pznw2ciu	278	15	receptor	receptor	NN
cord-016523-pznw2ciu	278	16	signals	signal	VBZ
cord-016523-pznw2ciu	278	17	cell	cell	NN
cord-016523-pznw2ciu	278	18	death	death	NN
cord-016523-pznw2ciu	279	1	The	the	DT
cord-016523-pznw2ciu	279	2	growth	growth	NN
cord-016523-pznw2ciu	279	3	factor	factor	NN
cord-016523-pznw2ciu	279	4	progranulin	progranulin	NNP
cord-016523-pznw2ciu	279	5	binds	bind	VBZ
cord-016523-pznw2ciu	279	6	to	to	IN
cord-016523-pznw2ciu	279	7	TNF	TNF	NNP
cord-016523-pznw2ciu	279	8	receptors	receptor	NNS
cord-016523-pznw2ciu	279	9	and	and	CC
cord-016523-pznw2ciu	279	10	is	be	VBZ
cord-016523-pznw2ciu	279	11	therapeutic	therapeutic	JJ
cord-016523-pznw2ciu	279	12	against	against	IN
cord-016523-pznw2ciu	279	13	infl	infl	NNP
cord-016523-pznw2ciu	279	14	ammatory	ammatory	NNP
cord-016523-pznw2ciu	279	15	arthritis	arthritis	NN
cord-016523-pznw2ciu	279	16	in	in	IN
cord-016523-pznw2ciu	279	17	mice	mouse	NNS
cord-016523-pznw2ciu	279	18	Signal	Signal	NNP
cord-016523-pznw2ciu	279	19	transduction	transduction	NN
cord-016523-pznw2ciu	279	20	by	by	IN
cord-016523-pznw2ciu	279	21	tumor	tumor	NN
cord-016523-pznw2ciu	279	22	necrosis	necrosis	NN
cord-016523-pznw2ciu	279	23	factor	factor	NN
cord-016523-pznw2ciu	280	1	receptors	receptor	NNS
cord-016523-pznw2ciu	280	2	A	a	DT
cord-016523-pznw2ciu	280	3	domain	domain	NN
cord-016523-pznw2ciu	280	4	in	in	IN
cord-016523-pznw2ciu	280	5	TNF	TNF	NNP
cord-016523-pznw2ciu	280	6	receptors	receptor	NNS
cord-016523-pznw2ciu	280	7	that	that	WDT
cord-016523-pznw2ciu	280	8	mediates	mediate	VBZ
cord-016523-pznw2ciu	280	9	ligand	ligand	NN
cord-016523-pznw2ciu	280	10	-	-	HYPH
cord-016523-pznw2ciu	280	11	independent	independent	JJ
cord-016523-pznw2ciu	280	12	receptor	receptor	NN
cord-016523-pznw2ciu	280	13	assembly	assembly	NN
cord-016523-pznw2ciu	280	14	and	and	CC
cord-016523-pznw2ciu	280	15	signaling	signal	VBG
cord-016523-pznw2ciu	280	16	Human	human	JJ
cord-016523-pznw2ciu	280	17	tumour	tumour	NN
cord-016523-pznw2ciu	280	18	necrosis	necrosis	NN
cord-016523-pznw2ciu	280	19	factor	factor	NN
cord-016523-pznw2ciu	280	20	:	:	:
cord-016523-pznw2ciu	280	21	precursor	precursor	NN
cord-016523-pznw2ciu	280	22	structure	structure	NN
cord-016523-pznw2ciu	280	23	,	,	,
cord-016523-pznw2ciu	280	24	expression	expression	NN
cord-016523-pznw2ciu	280	25	and	and	CC
cord-016523-pznw2ciu	280	26	homology	homology	NN
cord-016523-pznw2ciu	280	27	to	to	TO
cord-016523-pznw2ciu	280	28	lymphotoxin	lymphotoxin	VB
cord-016523-pznw2ciu	280	29	A	a	DT
cord-016523-pznw2ciu	280	30	metalloproteinase	metalloproteinase	NN
cord-016523-pznw2ciu	280	31	disintegrin	disintegrin	NN
cord-016523-pznw2ciu	280	32	that	that	WDT
cord-016523-pznw2ciu	280	33	releases	release	VBZ
cord-016523-pznw2ciu	280	34	tumour	tumour	NN
cord-016523-pznw2ciu	280	35	-	-	HYPH
cord-016523-pznw2ciu	280	36	necrosis	necrosis	NN
cord-016523-pznw2ciu	280	37	factor	factor	NN
cord-016523-pznw2ciu	280	38	-	-	HYPH
cord-016523-pznw2ciu	280	39	alpha	alpha	NN
cord-016523-pznw2ciu	280	40	from	from	IN
cord-016523-pznw2ciu	280	41	cells	cell	NNS
cord-016523-pznw2ciu	280	42	Cloning	clone	VBG
cord-016523-pznw2ciu	280	43	of	of	IN
cord-016523-pznw2ciu	280	44	a	a	DT
cord-016523-pznw2ciu	280	45	disintegrin	disintegrin	JJ
cord-016523-pznw2ciu	280	46	metalloproteinase	metalloproteinase	NN
cord-016523-pznw2ciu	280	47	that	that	WDT
cord-016523-pznw2ciu	280	48	processes	process	VBZ
cord-016523-pznw2ciu	280	49	precursor	precursor	NN
cord-016523-pznw2ciu	280	50	tumour	tumour	NN
cord-016523-pznw2ciu	280	51	-	-	HYPH
cord-016523-pznw2ciu	280	52	necrosis	necrosis	NN
cord-016523-pznw2ciu	280	53	factor	factor	NN
cord-016523-pznw2ciu	280	54	-	-	HYPH
cord-016523-pznw2ciu	280	55	alpha	alpha	NN
cord-016523-pznw2ciu	280	56	The	the	DT
cord-016523-pznw2ciu	280	57	transmembrane	transmembrane	JJ
cord-016523-pznw2ciu	280	58	form	form	NN
cord-016523-pznw2ciu	280	59	of	of	IN
cord-016523-pznw2ciu	280	60	tumor	tumor	NN
cord-016523-pznw2ciu	280	61	necrosis	necrosis	NN
cord-016523-pznw2ciu	280	62	factor	factor	NN
cord-016523-pznw2ciu	280	63	is	be	VBZ
cord-016523-pznw2ciu	280	64	the	the	DT
cord-016523-pznw2ciu	280	65	prime	prime	JJ
cord-016523-pznw2ciu	280	66	activating	activate	VBG
cord-016523-pznw2ciu	280	67	ligand	ligand	NN
cord-016523-pznw2ciu	280	68	of	of	IN
cord-016523-pznw2ciu	280	69	the	the	DT
cord-016523-pznw2ciu	280	70	80	80	CD
cord-016523-pznw2ciu	280	71	kDa	kDa	NNP
cord-016523-pznw2ciu	280	72	tumor	tumor	NN
cord-016523-pznw2ciu	280	73	necrosis	necrosis	NN
cord-016523-pznw2ciu	280	74	factor	factor	NN
cord-016523-pznw2ciu	280	75	receptor	receptor	NN
cord-016523-pznw2ciu	280	76	NF	NF	NNP
cord-016523-pznw2ciu	280	77	-	-	HYPH
cord-016523-pznw2ciu	280	78	kappaB	kappaB	NNP
cord-016523-pznw2ciu	280	79	antiapoptosis	antiapoptosis	NN
cord-016523-pznw2ciu	280	80	:	:	:
cord-016523-pznw2ciu	280	81	induction	induction	NN
cord-016523-pznw2ciu	280	82	of	of	IN
cord-016523-pznw2ciu	280	83	TRAF1	TRAF1	NNP
cord-016523-pznw2ciu	281	1	and	and	CC
cord-016523-pznw2ciu	281	2	TRAF2	TRAF2	NNP
cord-016523-pznw2ciu	281	3	and	and	CC
cord-016523-pznw2ciu	281	4	c	c	NN
cord-016523-pznw2ciu	281	5	-	-	:
cord-016523-pznw2ciu	281	6	IAP1	IAP1	NNP
cord-016523-pznw2ciu	281	7	and	and	CC
cord-016523-pznw2ciu	281	8	c	c	NN
cord-016523-pznw2ciu	281	9	-	-	:
cord-016523-pznw2ciu	281	10	IAP2	IAP2	NNP
cord-016523-pznw2ciu	282	1	to	to	TO
cord-016523-pznw2ciu	282	2	suppress	suppress	VB
cord-016523-pznw2ciu	282	3	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	282	4	activation	activation	NN
cord-016523-pznw2ciu	282	5	Recruitment	Recruitment	NNP
cord-016523-pznw2ciu	282	6	of	of	IN
cord-016523-pznw2ciu	282	7	the	the	DT
cord-016523-pznw2ciu	282	8	linear	linear	JJ
cord-016523-pznw2ciu	282	9	ubiquitin	ubiquitin	NN
cord-016523-pznw2ciu	282	10	chain	chain	NN
cord-016523-pznw2ciu	282	11	assembly	assembly	NN
cord-016523-pznw2ciu	282	12	complex	complex	NN
cord-016523-pznw2ciu	282	13	stabilizes	stabilize	VBZ
cord-016523-pznw2ciu	282	14	the	the	DT
cord-016523-pznw2ciu	282	15	TNF	TNF	NNP
cord-016523-pznw2ciu	282	16	-	-	HYPH
cord-016523-pznw2ciu	282	17	R1	R1	NNP
cord-016523-pznw2ciu	282	18	signaling	signal	VBG
cord-016523-pznw2ciu	282	19	complex	complex	NN
cord-016523-pznw2ciu	282	20	and	and	CC
cord-016523-pznw2ciu	282	21	is	be	VBZ
cord-016523-pznw2ciu	282	22	required	require	VBN
cord-016523-pznw2ciu	282	23	for	for	IN
cord-016523-pznw2ciu	282	24	TNF	TNF	NNP
cord-016523-pznw2ciu	282	25	-	-	HYPH
cord-016523-pznw2ciu	282	26	mediated	mediate	VBN
cord-016523-pznw2ciu	282	27	gene	gene	NN
cord-016523-pznw2ciu	282	28	induction	induction	NN
cord-016523-pznw2ciu	282	29	A	a	DT
cord-016523-pznw2ciu	282	30	ubiquitin	ubiquitin	NN
cord-016523-pznw2ciu	282	31	ligase	ligase	NN
cord-016523-pznw2ciu	282	32	complex	complex	NN
cord-016523-pznw2ciu	282	33	assembles	assemble	VBZ
cord-016523-pznw2ciu	282	34	linear	linear	JJ
cord-016523-pznw2ciu	282	35	polyubiquitin	polyubiquitin	NNS
cord-016523-pznw2ciu	282	36	chains	chain	NNS
cord-016523-pznw2ciu	283	1	Linear	linear	JJ
cord-016523-pznw2ciu	283	2	ubiquitination	ubiquitination	NN
cord-016523-pznw2ciu	283	3	prevents	prevent	VBZ
cord-016523-pznw2ciu	283	4	infl	infl	NN
cord-016523-pznw2ciu	283	5	ammation	ammation	NN
cord-016523-pznw2ciu	283	6	and	and	CC
cord-016523-pznw2ciu	283	7	regulates	regulate	VBZ
cord-016523-pznw2ciu	283	8	immune	immune	VBP
cord-016523-pznw2ciu	283	9	signalling	signal	VBG
cord-016523-pznw2ciu	283	10	Rapid	rapid	JJ
cord-016523-pznw2ciu	283	11	turnover	turnover	NN
cord-016523-pznw2ciu	283	12	of	of	IN
cord-016523-pznw2ciu	283	13	c	c	NN
cord-016523-pznw2ciu	283	14	-	-	HYPH
cord-016523-pznw2ciu	283	15	FLIPshort	FLIPshort	NNP
cord-016523-pznw2ciu	283	16	is	be	VBZ
cord-016523-pznw2ciu	283	17	determined	determine	VBN
cord-016523-pznw2ciu	283	18	by	by	IN
cord-016523-pznw2ciu	283	19	its	-PRON-	PRP$
cord-016523-pznw2ciu	283	20	unique	unique	JJ
cord-016523-pznw2ciu	283	21	C	c	NN
cord-016523-pznw2ciu	283	22	-	-	HYPH
cord-016523-pznw2ciu	283	23	terminal	terminal	NN
cord-016523-pznw2ciu	283	24	tail	tail	NN
cord-016523-pznw2ciu	283	25	NF	nf	NN
cord-016523-pznw2ciu	283	26	-	-	HYPH
cord-016523-pznw2ciu	283	27	kappaB	kappaB	NNP
cord-016523-pznw2ciu	283	28	suppression	suppression	NN
cord-016523-pznw2ciu	283	29	by	by	IN
cord-016523-pznw2ciu	283	30	the	the	DT
cord-016523-pznw2ciu	283	31	deubiquitinating	deubiquitinating	NN
cord-016523-pznw2ciu	283	32	enzyme	enzyme	NN
cord-016523-pznw2ciu	283	33	Cezanne	Cezanne	NNP
cord-016523-pznw2ciu	283	34	:	:	:
cord-016523-pznw2ciu	283	35	a	a	DT
cord-016523-pznw2ciu	283	36	novel	novel	JJ
cord-016523-pznw2ciu	283	37	negative	negative	JJ
cord-016523-pznw2ciu	283	38	feedback	feedback	NN
cord-016523-pznw2ciu	283	39	loop	loop	NN
cord-016523-pznw2ciu	283	40	in	in	IN
cord-016523-pznw2ciu	283	41	pro	pro	JJ
cord-016523-pznw2ciu	283	42	-	-	JJ
cord-016523-pznw2ciu	283	43	infl	infl	JJ
cord-016523-pznw2ciu	283	44	ammatory	ammatory	NN
cord-016523-pznw2ciu	283	45	signaling	signal	VBG
cord-016523-pznw2ciu	283	46	RIPK	ripk	NN
cord-016523-pznw2ciu	283	47	-	-	HYPH
cord-016523-pznw2ciu	283	48	dependent	dependent	JJ
cord-016523-pznw2ciu	283	49	necrosis	necrosis	NN
cord-016523-pznw2ciu	283	50	and	and	CC
cord-016523-pznw2ciu	283	51	its	-PRON-	PRP$
cord-016523-pznw2ciu	283	52	regulation	regulation	NN
cord-016523-pznw2ciu	283	53	by	by	IN
cord-016523-pznw2ciu	283	54	caspases	caspase	NNS
cord-016523-pznw2ciu	283	55	:	:	:
cord-016523-pznw2ciu	283	56	a	a	DT
cord-016523-pznw2ciu	283	57	mystery	mystery	NN
cord-016523-pznw2ciu	283	58	in	in	IN
cord-016523-pznw2ciu	283	59	fi	fi	NN
cord-016523-pznw2ciu	284	1	ve	ve	NNP
cord-016523-pznw2ciu	284	2	acts	act	VBZ
cord-016523-pznw2ciu	284	3	Fas	Fas	NNP
cord-016523-pznw2ciu	284	4	triggers	trigger	VBZ
cord-016523-pznw2ciu	284	5	an	an	DT
cord-016523-pznw2ciu	284	6	alternative	alternative	NN
cord-016523-pznw2ciu	284	7	,	,	,
cord-016523-pznw2ciu	284	8	caspase-8-independent	caspase-8-independent	NNP
cord-016523-pznw2ciu	284	9	cell	cell	NN
cord-016523-pznw2ciu	284	10	death	death	NN
cord-016523-pznw2ciu	284	11	pathway	pathway	NN
cord-016523-pznw2ciu	284	12	using	use	VBG
cord-016523-pznw2ciu	284	13	the	the	DT
cord-016523-pznw2ciu	284	14	kinase	kinase	NN
cord-016523-pznw2ciu	284	15	RIP	rip	NN
cord-016523-pznw2ciu	284	16	as	as	IN
cord-016523-pznw2ciu	284	17	effector	effector	NN
cord-016523-pznw2ciu	284	18	molecule	molecule	NN
cord-016523-pznw2ciu	284	19	Inhibition	inhibition	NN
cord-016523-pznw2ciu	284	20	of	of	IN
cord-016523-pznw2ciu	284	21	caspases	caspase	NNS
cord-016523-pznw2ciu	284	22	increases	increase	VBZ
cord-016523-pznw2ciu	284	23	the	the	DT
cord-016523-pznw2ciu	284	24	sensitivity	sensitivity	NN
cord-016523-pznw2ciu	284	25	of	of	IN
cord-016523-pznw2ciu	284	26	L929	l929	JJ
cord-016523-pznw2ciu	284	27	cells	cell	NNS
cord-016523-pznw2ciu	284	28	to	to	IN
cord-016523-pznw2ciu	284	29	necrosis	necrosis	NN
cord-016523-pznw2ciu	284	30	mediated	mediate	VBN
cord-016523-pznw2ciu	284	31	by	by	IN
cord-016523-pznw2ciu	284	32	tumor	tumor	NN
cord-016523-pznw2ciu	284	33	necrosis	necrosis	NN
cord-016523-pznw2ciu	284	34	factor	factor	NN
cord-016523-pznw2ciu	284	35	Phosphorylation	Phosphorylation	NNP
cord-016523-pznw2ciu	284	36	-	-	HYPH
cord-016523-pznw2ciu	284	37	driven	drive	VBN
cord-016523-pznw2ciu	284	38	assembly	assembly	NN
cord-016523-pznw2ciu	284	39	of	of	IN
cord-016523-pznw2ciu	284	40	the	the	DT
cord-016523-pznw2ciu	284	41	RIP1-RIP3	RIP1-RIP3	NNP
cord-016523-pznw2ciu	284	42	complex	complex	NN
cord-016523-pznw2ciu	284	43	regulates	regulate	VBZ
cord-016523-pznw2ciu	284	44	programmed	program	VBN
cord-016523-pznw2ciu	284	45	necrosis	necrosis	NN
cord-016523-pznw2ciu	284	46	and	and	CC
cord-016523-pznw2ciu	285	1	virus	virus	NN
cord-016523-pznw2ciu	285	2	-	-	HYPH
cord-016523-pznw2ciu	285	3	induced	induce	VBN
cord-016523-pznw2ciu	285	4	infl	infl	NN
cord-016523-pznw2ciu	285	5	ammation	ammation	NNP
cord-016523-pznw2ciu	285	6	RIP3	RIP3	NNP
cord-016523-pznw2ciu	285	7	mediates	mediate	VBZ
cord-016523-pznw2ciu	285	8	the	the	DT
cord-016523-pznw2ciu	285	9	embryonic	embryonic	JJ
cord-016523-pznw2ciu	285	10	lethality	lethality	NN
cord-016523-pznw2ciu	285	11	of	of	IN
cord-016523-pznw2ciu	285	12	caspase-8-defi	caspase-8-defi	NNP
cord-016523-pznw2ciu	285	13	cient	cient	NN
cord-016523-pznw2ciu	285	14	mice	mice	NN
cord-016523-pznw2ciu	285	15	Catalytic	catalytic	JJ
cord-016523-pznw2ciu	285	16	activity	activity	NN
cord-016523-pznw2ciu	285	17	of	of	IN
cord-016523-pznw2ciu	285	18	the	the	DT
cord-016523-pznw2ciu	285	19	caspase-8-FLIP(L	caspase-8-flip(l	NN
cord-016523-pznw2ciu	285	20	)	)	-RRB-
cord-016523-pznw2ciu	285	21	complex	complex	JJ
cord-016523-pznw2ciu	286	1	inhibits	inhibit	VBZ
cord-016523-pznw2ciu	286	2	RIPK3-dependent	RIPK3-dependent	:
cord-016523-pznw2ciu	286	3	necrosis	necrosis	NN
cord-016523-pznw2ciu	286	4	FADD	FADD	NNP
cord-016523-pznw2ciu	286	5	prevents	prevent	VBZ
cord-016523-pznw2ciu	286	6	RIP3-mediated	rip3-mediate	VBN
cord-016523-pznw2ciu	286	7	epithelial	epithelial	JJ
cord-016523-pznw2ciu	286	8	cell	cell	NN
cord-016523-pznw2ciu	286	9	necrosis	necrosis	NN
cord-016523-pznw2ciu	286	10	and	and	CC
cord-016523-pznw2ciu	286	11	chronic	chronic	JJ
cord-016523-pznw2ciu	286	12	intestinal	intestinal	JJ
cord-016523-pznw2ciu	286	13	infl	infl	NN
cord-016523-pznw2ciu	286	14	ammation	ammation	NN
cord-016523-pznw2ciu	286	15	Lasker	Lasker	NNP
cord-016523-pznw2ciu	286	16	Clinical	Clinical	NNP
cord-016523-pznw2ciu	286	17	Medical	Medical	NNP
cord-016523-pznw2ciu	286	18	Research	Research	NNP
cord-016523-pznw2ciu	286	19	Award	Award	NNP
cord-016523-pznw2ciu	286	20	TNF	TNF	NNP
cord-016523-pznw2ciu	286	21	defi	defi	NN
cord-016523-pznw2ciu	286	22	ned	ned	NNP
cord-016523-pznw2ciu	286	23	as	as	IN
cord-016523-pznw2ciu	286	24	a	a	DT
cord-016523-pznw2ciu	286	25	therapeutic	therapeutic	JJ
cord-016523-pznw2ciu	286	26	target	target	NN
cord-016523-pznw2ciu	286	27	for	for	IN
cord-016523-pznw2ciu	286	28	rheumatoid	rheumatoid	NN
cord-016523-pznw2ciu	286	29	arthritis	arthritis	NN
cord-016523-pznw2ciu	286	30	and	and	CC
cord-016523-pznw2ciu	286	31	other	other	JJ
cord-016523-pznw2ciu	286	32	autoimmune	autoimmune	JJ
cord-016523-pznw2ciu	286	33	diseases	disease	NNS
cord-016523-pznw2ciu	287	1	Fas	Fas	NNP
cord-016523-pznw2ciu	287	2	engagement	engagement	NN
cord-016523-pznw2ciu	287	3	induces	induce	VBZ
cord-016523-pznw2ciu	287	4	neurite	neurite	NN
cord-016523-pznw2ciu	287	5	growth	growth	NN
cord-016523-pznw2ciu	287	6	through	through	IN
cord-016523-pznw2ciu	287	7	ERK	ERK	NNP
cord-016523-pznw2ciu	287	8	activation	activation	NN
cord-016523-pznw2ciu	287	9	and	and	CC
cord-016523-pznw2ciu	288	1	p35	p35	CD
cord-016523-pznw2ciu	288	2	upregulation	upregulation	NN
cord-016523-pznw2ciu	288	3	Fas	Fas	NNP
cord-016523-pznw2ciu	288	4	engagement	engagement	NN
cord-016523-pznw2ciu	288	5	accelerates	accelerate	VBZ
cord-016523-pznw2ciu	288	6	liver	liver	NN
cord-016523-pznw2ciu	288	7	regeneration	regeneration	NN
cord-016523-pznw2ciu	288	8	after	after	IN
cord-016523-pznw2ciu	288	9	partial	partial	JJ
cord-016523-pznw2ciu	288	10	hepatectomy	hepatectomy	NN
cord-016523-pznw2ciu	288	11	CD95-ligand	cd95-ligand	CD
cord-016523-pznw2ciu	288	12	on	on	IN
cord-016523-pznw2ciu	288	13	peripheral	peripheral	JJ
cord-016523-pznw2ciu	288	14	myeloid	myeloid	NN
cord-016523-pznw2ciu	288	15	cells	cell	NNS
cord-016523-pznw2ciu	288	16	activates	activate	VBZ
cord-016523-pznw2ciu	288	17	Syk	Syk	NNP
cord-016523-pznw2ciu	288	18	kinase	kinase	NN
cord-016523-pznw2ciu	288	19	to	to	TO
cord-016523-pznw2ciu	288	20	trigger	trigger	VB
cord-016523-pznw2ciu	288	21	their	-PRON-	PRP$
cord-016523-pznw2ciu	288	22	recruitment	recruitment	NN
cord-016523-pznw2ciu	288	23	to	to	IN
cord-016523-pznw2ciu	288	24	the	the	DT
cord-016523-pznw2ciu	288	25	infl	infl	NNP
cord-016523-pznw2ciu	288	26	ammatory	ammatory	NNP
cord-016523-pznw2ciu	288	27	site	site	NN
cord-016523-pznw2ciu	289	1	Membrane	membrane	NN
cord-016523-pznw2ciu	289	2	-	-	HYPH
cord-016523-pznw2ciu	289	3	bound	bind	VBN
cord-016523-pznw2ciu	289	4	Fas	Fas	NNP
cord-016523-pznw2ciu	289	5	ligand	ligand	NN
cord-016523-pznw2ciu	289	6	only	only	RB
cord-016523-pznw2ciu	289	7	is	be	VBZ
cord-016523-pznw2ciu	289	8	essential	essential	JJ
cord-016523-pznw2ciu	289	9	for	for	IN
cord-016523-pznw2ciu	290	1	Fas	Fas	NNP
cord-016523-pznw2ciu	290	2	-	-	HYPH
cord-016523-pznw2ciu	290	3	induced	induce	VBN
cord-016523-pznw2ciu	290	4	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	291	1	A	a	DT
cord-016523-pznw2ciu	291	2	novel	novel	JJ
cord-016523-pznw2ciu	291	3	juxtamembrane	juxtamembrane	NNP
cord-016523-pznw2ciu	291	4	domain	domain	NN
cord-016523-pznw2ciu	291	5	in	in	IN
cord-016523-pznw2ciu	291	6	tumor	tumor	NN
cord-016523-pznw2ciu	291	7	necrosis	necrosis	NN
cord-016523-pznw2ciu	291	8	factor	factor	NN
cord-016523-pznw2ciu	291	9	receptor	receptor	NN
cord-016523-pznw2ciu	291	10	superfamily	superfamily	NN
cord-016523-pznw2ciu	291	11	molecules	molecule	NNS
cord-016523-pznw2ciu	291	12	activates	activate	VBZ
cord-016523-pznw2ciu	291	13	Rac1	Rac1	NNP
cord-016523-pznw2ciu	291	14	and	and	CC
cord-016523-pznw2ciu	291	15	controls	control	NNS
cord-016523-pznw2ciu	291	16	neurite	neurite	NN
cord-016523-pznw2ciu	291	17	growth	growth	NN
cord-016523-pznw2ciu	292	1	The	the	DT
cord-016523-pznw2ciu	292	2	naturally	naturally	RB
cord-016523-pznw2ciu	292	3	processed	process	VBN
cord-016523-pznw2ciu	292	4	CD95L	cd95l	NN
cord-016523-pznw2ciu	292	5	elicits	elicit	VBZ
cord-016523-pznw2ciu	292	6	a	a	DT
cord-016523-pznw2ciu	292	7	c	c	NN
cord-016523-pznw2ciu	292	8	-	-	:
cord-016523-pznw2ciu	292	9	yes	yes	UH
cord-016523-pznw2ciu	292	10	/	/	SYM
cord-016523-pznw2ciu	292	11	calcium	calcium	NN
cord-016523-pznw2ciu	292	12	/	/	SYM
cord-016523-pznw2ciu	292	13	PI3K	PI3K	NNP
cord-016523-pznw2ciu	292	14	-	-	HYPH
cord-016523-pznw2ciu	292	15	driven	drive	VBN
cord-016523-pznw2ciu	292	16	cell	cell	NN
cord-016523-pznw2ciu	292	17	migration	migration	NN
cord-016523-pznw2ciu	292	18	pathway	pathway	NN
cord-016523-pznw2ciu	292	19	CD95-mediated	cd95-mediated	CD
cord-016523-pznw2ciu	292	20	cell	cell	NN
cord-016523-pznw2ciu	292	21	signaling	signal	VBG
cord-016523-pznw2ciu	292	22	in	in	IN
cord-016523-pznw2ciu	292	23	cancer	cancer	NN
cord-016523-pznw2ciu	292	24	:	:	:
cord-016523-pznw2ciu	293	1	mutations	mutation	NNS
cord-016523-pznw2ciu	293	2	and	and	CC
cord-016523-pznw2ciu	293	3	post	post	JJ
cord-016523-pznw2ciu	293	4	-	-	JJ
cord-016523-pznw2ciu	293	5	translational	translational	JJ
cord-016523-pznw2ciu	293	6	modulations	modulation	NNS
cord-016523-pznw2ciu	294	1	Monoclonal	monoclonal	JJ
cord-016523-pznw2ciu	294	2	antibody	antibody	NN
cord-016523-pznw2ciu	294	3	-	-	HYPH
cord-016523-pznw2ciu	294	4	mediated	mediate	VBN
cord-016523-pznw2ciu	294	5	tumor	tumor	NN
cord-016523-pznw2ciu	294	6	regression	regression	NN
cord-016523-pznw2ciu	294	7	by	by	IN
cord-016523-pznw2ciu	294	8	induction	induction	NN
cord-016523-pznw2ciu	294	9	of	of	IN
cord-016523-pznw2ciu	294	10	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	294	11	Molecular	molecular	JJ
cord-016523-pznw2ciu	294	12	cloning	cloning	NN
cord-016523-pznw2ciu	294	13	and	and	CC
cord-016523-pznw2ciu	294	14	expression	expression	NN
cord-016523-pznw2ciu	294	15	of	of	IN
cord-016523-pznw2ciu	294	16	the	the	DT
cord-016523-pznw2ciu	294	17	Fas	Fas	NNP
cord-016523-pznw2ciu	294	18	ligand	ligand	NN
cord-016523-pznw2ciu	294	19	,	,	,
cord-016523-pznw2ciu	294	20	a	a	DT
cord-016523-pznw2ciu	294	21	novel	novel	JJ
cord-016523-pznw2ciu	294	22	member	member	NN
cord-016523-pznw2ciu	294	23	of	of	IN
cord-016523-pznw2ciu	294	24	the	the	DT
cord-016523-pznw2ciu	294	25	tumor	tumor	NN
cord-016523-pznw2ciu	294	26	necrosis	necrosis	NN
cord-016523-pznw2ciu	294	27	factor	factor	NN
cord-016523-pznw2ciu	294	28	family	family	NN
cord-016523-pznw2ciu	294	29	Involvement	Involvement	NNP
cord-016523-pznw2ciu	294	30	of	of	IN
cord-016523-pznw2ciu	294	31	Fas	Fas	NNP
cord-016523-pznw2ciu	294	32	ligand	ligand	NN
cord-016523-pznw2ciu	294	33	and	and	CC
cord-016523-pznw2ciu	294	34	Fasmediated	fasmediated	JJ
cord-016523-pznw2ciu	294	35	pathway	pathway	NN
cord-016523-pznw2ciu	294	36	in	in	IN
cord-016523-pznw2ciu	294	37	the	the	DT
cord-016523-pznw2ciu	294	38	cytotoxicity	cytotoxicity	NN
cord-016523-pznw2ciu	294	39	of	of	IN
cord-016523-pznw2ciu	294	40	human	human	JJ
cord-016523-pznw2ciu	294	41	natural	natural	JJ
cord-016523-pznw2ciu	294	42	killer	killer	NN
cord-016523-pznw2ciu	294	43	cells	cell	NNS
cord-016523-pznw2ciu	295	1	Fas	Fas	NNP
cord-016523-pznw2ciu	295	2	ligand	ligand	NN
cord-016523-pznw2ciu	295	3	-	-	HYPH
cord-016523-pznw2ciu	295	4	induced	induce	VBN
cord-016523-pznw2ciu	295	5	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	295	6	as	as	IN
cord-016523-pznw2ciu	295	7	a	a	DT
cord-016523-pznw2ciu	295	8	mechanism	mechanism	NN
cord-016523-pznw2ciu	295	9	of	of	IN
cord-016523-pznw2ciu	295	10	immune	immune	JJ
cord-016523-pznw2ciu	295	11	privilege	privilege	NN
cord-016523-pznw2ciu	295	12	A	a	DT
cord-016523-pznw2ciu	295	13	role	role	NN
cord-016523-pznw2ciu	295	14	for	for	IN
cord-016523-pznw2ciu	295	15	CD95	CD95	NNP
cord-016523-pznw2ciu	295	16	ligand	ligand	NN
cord-016523-pznw2ciu	295	17	in	in	IN
cord-016523-pznw2ciu	295	18	preventing	prevent	VBG
cord-016523-pznw2ciu	295	19	graft	graft	NN
cord-016523-pznw2ciu	295	20	rejection	rejection	NN
cord-016523-pznw2ciu	295	21	Lymphoproliferation	Lymphoproliferation	NNP
cord-016523-pznw2ciu	295	22	disorder	disorder	NN
cord-016523-pznw2ciu	295	23	in	in	IN
cord-016523-pznw2ciu	295	24	mice	mouse	NNS
cord-016523-pznw2ciu	295	25	explained	explain	VBN
cord-016523-pznw2ciu	295	26	by	by	IN
cord-016523-pznw2ciu	295	27	defects	defect	NNS
cord-016523-pznw2ciu	295	28	in	in	IN
cord-016523-pznw2ciu	295	29	Fas	Fas	NNP
cord-016523-pznw2ciu	295	30	antigen	antigen	NN
cord-016523-pznw2ciu	295	31	that	that	WDT
cord-016523-pznw2ciu	295	32	mediates	mediate	VBZ
cord-016523-pznw2ciu	295	33	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	295	34	Aberrant	aberrant	JJ
cord-016523-pznw2ciu	295	35	transcription	transcription	NN
cord-016523-pznw2ciu	295	36	caused	cause	VBN
cord-016523-pznw2ciu	295	37	by	by	IN
cord-016523-pznw2ciu	295	38	the	the	DT
cord-016523-pznw2ciu	295	39	insertion	insertion	NN
cord-016523-pznw2ciu	295	40	of	of	IN
cord-016523-pznw2ciu	295	41	an	an	DT
cord-016523-pznw2ciu	295	42	early	early	JJ
cord-016523-pznw2ciu	295	43	transposable	transposable	JJ
cord-016523-pznw2ciu	295	44	element	element	NN
cord-016523-pznw2ciu	295	45	in	in	IN
cord-016523-pznw2ciu	295	46	an	an	DT
cord-016523-pznw2ciu	295	47	intron	intron	NN
cord-016523-pznw2ciu	295	48	of	of	IN
cord-016523-pznw2ciu	295	49	the	the	DT
cord-016523-pznw2ciu	295	50	Fas	Fas	NNP
cord-016523-pznw2ciu	295	51	antigen	antigen	NN
cord-016523-pznw2ciu	295	52	gene	gene	NN
cord-016523-pznw2ciu	295	53	of	of	IN
cord-016523-pznw2ciu	295	54	lpr	lpr	NNP
cord-016523-pznw2ciu	295	55	mice	mouse	NNS
cord-016523-pznw2ciu	296	1	The	the	DT
cord-016523-pznw2ciu	296	2	defect	defect	NN
cord-016523-pznw2ciu	296	3	in	in	IN
cord-016523-pznw2ciu	296	4	Fas	Fas	NNP
cord-016523-pznw2ciu	296	5	mRNA	mrna	NN
cord-016523-pznw2ciu	296	6	expression	expression	NN
cord-016523-pznw2ciu	296	7	in	in	IN
cord-016523-pznw2ciu	296	8	MRL	MRL	NNP
cord-016523-pznw2ciu	296	9	/	/	SYM
cord-016523-pznw2ciu	296	10	lpr	lpr	NN
cord-016523-pznw2ciu	296	11	mice	mouse	NNS
cord-016523-pznw2ciu	296	12	is	be	VBZ
cord-016523-pznw2ciu	296	13	associated	associate	VBN
cord-016523-pznw2ciu	296	14	with	with	IN
cord-016523-pznw2ciu	296	15	insertion	insertion	NN
cord-016523-pznw2ciu	296	16	of	of	IN
cord-016523-pznw2ciu	296	17	the	the	DT
cord-016523-pznw2ciu	296	18	retrotransposon	retrotransposon	NN
cord-016523-pznw2ciu	296	19	,	,	,
cord-016523-pznw2ciu	296	20	ETn	etn	IN
cord-016523-pznw2ciu	296	21	Autoimmunity	Autoimmunity	NNP
cord-016523-pznw2ciu	296	22	in	in	IN
cord-016523-pznw2ciu	296	23	mice	mouse	NNS
cord-016523-pznw2ciu	296	24	bearing	bearing	NN
cord-016523-pznw2ciu	296	25	lprcg	lprcg	NN
cord-016523-pznw2ciu	296	26	:	:	:
cord-016523-pznw2ciu	296	27	a	a	DT
cord-016523-pznw2ciu	296	28	novel	novel	JJ
cord-016523-pznw2ciu	296	29	mutant	mutant	JJ
cord-016523-pznw2ciu	296	30	gene	gene	NN
cord-016523-pznw2ciu	296	31	Generalized	generalize	VBN
cord-016523-pznw2ciu	296	32	lymphoproliferative	lymphoproliferative	JJ
cord-016523-pznw2ciu	296	33	disease	disease	NN
cord-016523-pznw2ciu	296	34	in	in	IN
cord-016523-pznw2ciu	296	35	mice	mouse	NNS
cord-016523-pznw2ciu	296	36	,	,	,
cord-016523-pznw2ciu	296	37	caused	cause	VBN
cord-016523-pznw2ciu	296	38	by	by	IN
cord-016523-pznw2ciu	296	39	a	a	DT
cord-016523-pznw2ciu	296	40	point	point	NN
cord-016523-pznw2ciu	296	41	mutation	mutation	NN
cord-016523-pznw2ciu	296	42	in	in	IN
cord-016523-pznw2ciu	296	43	the	the	DT
cord-016523-pznw2ciu	296	44	Fas	Fas	NNP
cord-016523-pznw2ciu	296	45	ligand	ligand	NN
cord-016523-pznw2ciu	297	1	The	the	DT
cord-016523-pznw2ciu	297	2	many	many	JJ
cord-016523-pznw2ciu	297	3	roles	role	NNS
cord-016523-pznw2ciu	297	4	of	of	IN
cord-016523-pznw2ciu	297	5	FAS	FAS	NNP
cord-016523-pznw2ciu	297	6	receptor	receptor	NN
cord-016523-pznw2ciu	297	7	signaling	signal	VBG
cord-016523-pznw2ciu	297	8	in	in	IN
cord-016523-pznw2ciu	297	9	the	the	DT
cord-016523-pznw2ciu	297	10	immune	immune	JJ
cord-016523-pznw2ciu	297	11	system	system	NN
cord-016523-pznw2ciu	297	12	Structure	Structure	NNP
cord-016523-pznw2ciu	297	13	of	of	IN
cord-016523-pznw2ciu	297	14	the	the	DT
cord-016523-pznw2ciu	297	15	human	human	JJ
cord-016523-pznw2ciu	297	16	APO-1	APO-1	NNP
cord-016523-pznw2ciu	297	17	gene	gene	NN
cord-016523-pznw2ciu	297	18	NMR	NMR	NNP
cord-016523-pznw2ciu	297	19	structure	structure	NN
cord-016523-pznw2ciu	297	20	and	and	CC
cord-016523-pznw2ciu	297	21	mutagenesis	mutagenesis	NN
cord-016523-pznw2ciu	297	22	of	of	IN
cord-016523-pznw2ciu	297	23	the	the	DT
cord-016523-pznw2ciu	297	24	Fas	Fas	NNP
cord-016523-pznw2ciu	297	25	(	(	-LRB-
cord-016523-pznw2ciu	297	26	APO-1	APO-1	NNP
cord-016523-pznw2ciu	297	27	/	/	SYM
cord-016523-pznw2ciu	297	28	CD95	CD95	NNP
cord-016523-pznw2ciu	297	29	)	)	-RRB-
cord-016523-pznw2ciu	297	30	death	death	NN
cord-016523-pznw2ciu	297	31	domain	domain	NN
cord-016523-pznw2ciu	298	1	The	the	DT
cord-016523-pznw2ciu	298	2	Fas	Fas	NNP
cord-016523-pznw2ciu	298	3	-	-	HYPH
cord-016523-pznw2ciu	298	4	FADD	FADD	NNP
cord-016523-pznw2ciu	298	5	death	death	NN
cord-016523-pznw2ciu	298	6	domain	domain	NN
cord-016523-pznw2ciu	298	7	complex	complex	JJ
cord-016523-pznw2ciu	298	8	structure	structure	NN
cord-016523-pznw2ciu	298	9	unravels	unravel	VBZ
cord-016523-pznw2ciu	298	10	signalling	signal	VBG
cord-016523-pznw2ciu	298	11	by	by	IN
cord-016523-pznw2ciu	298	12	receptor	receptor	NN
cord-016523-pznw2ciu	298	13	clustering	cluster	VBG
cord-016523-pznw2ciu	298	14	Solution	Solution	NNP
cord-016523-pznw2ciu	298	15	NMR	NMR	NNP
cord-016523-pznw2ciu	298	16	investigation	investigation	NN
cord-016523-pznw2ciu	298	17	of	of	IN
cord-016523-pznw2ciu	298	18	the	the	DT
cord-016523-pznw2ciu	298	19	CD95	CD95	NNP
cord-016523-pznw2ciu	298	20	/	/	SYM
cord-016523-pznw2ciu	298	21	FADD	FADD	NNP
cord-016523-pznw2ciu	298	22	homotypic	homotypic	NNP
cord-016523-pznw2ciu	298	23	death	death	NN
cord-016523-pznw2ciu	298	24	domain	domain	NN
cord-016523-pznw2ciu	298	25	complex	complex	NN
cord-016523-pznw2ciu	298	26	suggests	suggest	VBZ
cord-016523-pznw2ciu	298	27	lack	lack	NN
cord-016523-pznw2ciu	298	28	of	of	IN
cord-016523-pznw2ciu	298	29	engagement	engagement	NN
cord-016523-pznw2ciu	298	30	of	of	IN
cord-016523-pznw2ciu	298	31	the	the	DT
cord-016523-pznw2ciu	298	32	CD95	CD95	NNP
cord-016523-pznw2ciu	298	33	C	C	NNP
cord-016523-pznw2ciu	298	34	terminus	terminus	NN
cord-016523-pznw2ciu	299	1	The	the	DT
cord-016523-pznw2ciu	299	2	Fas	Fas	NNP
cord-016523-pznw2ciu	299	3	-	-	HYPH
cord-016523-pznw2ciu	299	4	FADD	FADD	NNP
cord-016523-pznw2ciu	299	5	death	death	NN
cord-016523-pznw2ciu	299	6	domain	domain	NN
cord-016523-pznw2ciu	299	7	complex	complex	JJ
cord-016523-pznw2ciu	299	8	structure	structure	NN
cord-016523-pznw2ciu	299	9	reveals	reveal	VBZ
cord-016523-pznw2ciu	299	10	the	the	DT
cord-016523-pznw2ciu	299	11	basis	basis	NN
cord-016523-pznw2ciu	299	12	of	of	IN
cord-016523-pznw2ciu	299	13	DISC	DISC	NNP
cord-016523-pznw2ciu	299	14	assembly	assembly	NN
cord-016523-pznw2ciu	299	15	and	and	CC
cord-016523-pznw2ciu	299	16	disease	disease	NN
cord-016523-pznw2ciu	299	17	mutations	mutation	NNS
cord-016523-pznw2ciu	299	18	Homotypic	Homotypic	NNP
cord-016523-pznw2ciu	299	19	FADD	FADD	NNP
cord-016523-pznw2ciu	299	20	interactions	interaction	NNS
cord-016523-pznw2ciu	299	21	through	through	IN
cord-016523-pznw2ciu	299	22	a	a	DT
cord-016523-pznw2ciu	299	23	conserved	conserve	VBN
cord-016523-pznw2ciu	299	24	RXDLL	rxdll	NN
cord-016523-pznw2ciu	299	25	motif	motif	NN
cord-016523-pznw2ciu	299	26	are	be	VBP
cord-016523-pznw2ciu	299	27	required	require	VBN
cord-016523-pznw2ciu	299	28	for	for	IN
cord-016523-pznw2ciu	299	29	death	death	NN
cord-016523-pznw2ciu	299	30	receptor	receptor	NN
cord-016523-pznw2ciu	299	31	-	-	HYPH
cord-016523-pznw2ciu	299	32	induced	induce	VBN
cord-016523-pznw2ciu	299	33	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	299	34	Inhibition	inhibition	NN
cord-016523-pznw2ciu	299	35	of	of	IN
cord-016523-pznw2ciu	299	36	death	death	NN
cord-016523-pznw2ciu	299	37	receptor	receptor	NN
cord-016523-pznw2ciu	299	38	signals	signal	NNS
cord-016523-pznw2ciu	299	39	by	by	IN
cord-016523-pznw2ciu	299	40	cellular	cellular	JJ
cord-016523-pznw2ciu	299	41	FLIP	FLIP	NNP
cord-016523-pznw2ciu	299	42	Viral	Viral	NNP
cord-016523-pznw2ciu	299	43	FLICE	flice	NN
cord-016523-pznw2ciu	299	44	-	-	HYPH
cord-016523-pznw2ciu	299	45	inhibitory	inhibitory	JJ
cord-016523-pznw2ciu	299	46	proteins	protein	NNS
cord-016523-pznw2ciu	299	47	(	(	-LRB-
cord-016523-pznw2ciu	299	48	FLIPs	flip	NNS
cord-016523-pznw2ciu	299	49	)	)	-RRB-
cord-016523-pznw2ciu	300	1	prevent	prevent	JJ
cord-016523-pznw2ciu	300	2	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	300	3	induced	induce	VBN
cord-016523-pznw2ciu	300	4	by	by	IN
cord-016523-pznw2ciu	300	5	death	death	NN
cord-016523-pznw2ciu	300	6	receptors	receptor	NNS
cord-016523-pznw2ciu	300	7	PED/	PED/	NNP
cord-016523-pznw2ciu	301	1	PEA-15	PEA-15	NNP
cord-016523-pznw2ciu	301	2	:	:	:
cord-016523-pznw2ciu	301	3	an	an	DT
cord-016523-pznw2ciu	301	4	anti	anti	JJ
cord-016523-pznw2ciu	301	5	-	-	JJ
cord-016523-pznw2ciu	301	6	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	301	7	molecule	molecule	NN
cord-016523-pznw2ciu	301	8	that	that	WDT
cord-016523-pznw2ciu	301	9	regulates	regulate	VBZ
cord-016523-pznw2ciu	302	1	FAS	FAS	NNP
cord-016523-pznw2ciu	302	2	/	/	SYM
cord-016523-pznw2ciu	302	3	TNFR1-induced	TNFR1-induced	NNP
cord-016523-pznw2ciu	302	4	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	302	5	APO-1	APO-1	NNP
cord-016523-pznw2ciu	302	6	/	/	SYM
cord-016523-pznw2ciu	302	7	Fas	Fas	NNP
cord-016523-pznw2ciu	302	8	)	)	-RRB-
cord-016523-pznw2ciu	303	1	signaling	signal	VBG
cord-016523-pznw2ciu	303	2	pathways	pathway	NNS
cord-016523-pznw2ciu	304	1	Two	two	CD
cord-016523-pznw2ciu	304	2	CD95	CD95	NNP
cord-016523-pznw2ciu	304	3	tumor	tumor	NN
cord-016523-pznw2ciu	304	4	classes	class	NNS
cord-016523-pznw2ciu	304	5	with	with	IN
cord-016523-pznw2ciu	304	6	different	different	JJ
cord-016523-pznw2ciu	304	7	sensitivities	sensitivity	NNS
cord-016523-pznw2ciu	304	8	to	to	IN
cord-016523-pznw2ciu	304	9	antitumor	antitumor	JJ
cord-016523-pznw2ciu	304	10	drugs	drug	NNS
cord-016523-pznw2ciu	304	11	CD95	CD95	NNP
cord-016523-pznw2ciu	304	12	engagement	engagement	NN
cord-016523-pznw2ciu	304	13	mediates	mediate	VBZ
cord-016523-pznw2ciu	304	14	actin	actin	NN
cord-016523-pznw2ciu	304	15	-	-	HYPH
cord-016523-pznw2ciu	304	16	independent	independent	JJ
cord-016523-pznw2ciu	304	17	and	and	CC
cord-016523-pznw2ciu	304	18	-dependent	-dependent	JJ
cord-016523-pznw2ciu	304	19	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	304	20	signals	signal	NNS
cord-016523-pznw2ciu	305	1	Signal	signal	NN
cord-016523-pznw2ciu	305	2	transduction	transduction	NN
cord-016523-pznw2ciu	305	3	mediated	mediate	VBN
cord-016523-pznw2ciu	305	4	by	by	IN
cord-016523-pznw2ciu	305	5	Bid	Bid	NNP
cord-016523-pznw2ciu	305	6	,	,	,
cord-016523-pznw2ciu	305	7	a	a	DT
cord-016523-pznw2ciu	305	8	pro	pro	JJ
cord-016523-pznw2ciu	305	9	-	-	JJ
cord-016523-pznw2ciu	305	10	death	death	NN
cord-016523-pznw2ciu	305	11	Bcl-2	Bcl-2	NNP
cord-016523-pznw2ciu	305	12	family	family	NN
cord-016523-pznw2ciu	305	13	proteins	protein	NNS
cord-016523-pznw2ciu	305	14	,	,	,
cord-016523-pznw2ciu	305	15	connects	connect	VBZ
cord-016523-pznw2ciu	306	1	the	the	DT
cord-016523-pznw2ciu	306	2	death	death	NN
cord-016523-pznw2ciu	306	3	receptor	receptor	NN
cord-016523-pznw2ciu	306	4	and	and	CC
cord-016523-pznw2ciu	306	5	mitochondria	mitochondrion	NNS
cord-016523-pznw2ciu	306	6	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	306	7	pathways	pathway	NNS
cord-016523-pznw2ciu	306	8	Bid	Bid	NNP
cord-016523-pznw2ciu	306	9	-	-	HYPH
cord-016523-pznw2ciu	306	10	defi	defi	NNP
cord-016523-pznw2ciu	306	11	cient	cient	NNP
cord-016523-pznw2ciu	306	12	mice	mouse	NNS
cord-016523-pznw2ciu	306	13	are	be	VBP
cord-016523-pznw2ciu	306	14	resistant	resistant	JJ
cord-016523-pznw2ciu	306	15	to	to	IN
cord-016523-pznw2ciu	306	16	Fas	Fas	NNP
cord-016523-pznw2ciu	306	17	-	-	HYPH
cord-016523-pznw2ciu	306	18	induced	induce	VBN
cord-016523-pznw2ciu	306	19	hepatocellular	hepatocellular	RB
cord-016523-pznw2ciu	307	1	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	307	2	XIAP	XIAP	NNP
cord-016523-pznw2ciu	307	3	discriminates	discriminate	VBZ
cord-016523-pznw2ciu	307	4	between	between	IN
cord-016523-pznw2ciu	307	5	type	type	NN
cord-016523-pznw2ciu	307	6	I	-PRON-	PRP
cord-016523-pznw2ciu	307	7	and	and	CC
cord-016523-pznw2ciu	307	8	type	type	NN
cord-016523-pznw2ciu	307	9	II	II	NNP
cord-016523-pznw2ciu	307	10	FAS	FAS	NNP
cord-016523-pznw2ciu	307	11	-	-	HYPH
cord-016523-pznw2ciu	307	12	induced	induce	VBN
cord-016523-pznw2ciu	307	13	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	307	14	The	the	DT
cord-016523-pznw2ciu	307	15	c	c	NN
cord-016523-pznw2ciu	307	16	-	-	:
cord-016523-pznw2ciu	307	17	IAP-1	IAP-1	NNP
cord-016523-pznw2ciu	307	18	and	and	CC
cord-016523-pznw2ciu	307	19	c	c	LS
cord-016523-pznw2ciu	307	20	-	-	:
cord-016523-pznw2ciu	307	21	IAP-2	IAP-2	NNP
cord-016523-pznw2ciu	307	22	proteins	protein	NNS
cord-016523-pznw2ciu	308	1	are	be	VBP
cord-016523-pznw2ciu	308	2	direct	direct	JJ
cord-016523-pznw2ciu	308	3	inhibitors	inhibitor	NNS
cord-016523-pznw2ciu	308	4	of	of	IN
cord-016523-pznw2ciu	308	5	specifi	specifi	NNP
cord-016523-pznw2ciu	308	6	c	c	NN
cord-016523-pznw2ciu	308	7	caspases	caspases	NNP
cord-016523-pznw2ciu	308	8	X	x	NN
cord-016523-pznw2ciu	308	9	-	-	HYPH
cord-016523-pznw2ciu	308	10	linked	link	VBN
cord-016523-pznw2ciu	308	11	IAP	IAP	NNP
cord-016523-pznw2ciu	308	12	is	be	VBZ
cord-016523-pznw2ciu	308	13	a	a	DT
cord-016523-pznw2ciu	308	14	direct	direct	JJ
cord-016523-pznw2ciu	308	15	inhibitor	inhibitor	NN
cord-016523-pznw2ciu	308	16	of	of	IN
cord-016523-pznw2ciu	308	17	cell	cell	NN
cord-016523-pznw2ciu	308	18	-	-	HYPH
cord-016523-pznw2ciu	308	19	death	death	NN
cord-016523-pznw2ciu	308	20	proteases	protease	NNS
cord-016523-pznw2ciu	308	21	IAPs	iaps	NN
cord-016523-pznw2ciu	308	22	block	block	VBP
cord-016523-pznw2ciu	308	23	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	308	24	events	event	NNS
cord-016523-pznw2ciu	308	25	induced	induce	VBN
cord-016523-pznw2ciu	308	26	by	by	IN
cord-016523-pznw2ciu	308	27	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	308	28	and	and	CC
cord-016523-pznw2ciu	308	29	cytochrome	cytochrome	NN
cord-016523-pznw2ciu	308	30	c	c	NN
cord-016523-pznw2ciu	308	31	by	by	IN
cord-016523-pznw2ciu	308	32	direct	direct	JJ
cord-016523-pznw2ciu	308	33	inhibition	inhibition	NN
cord-016523-pznw2ciu	308	34	of	of	IN
cord-016523-pznw2ciu	308	35	distinct	distinct	JJ
cord-016523-pznw2ciu	308	36	caspases	caspase	NNS
cord-016523-pznw2ciu	308	37	Ubiquitinprotein	Ubiquitinprotein	NNP
cord-016523-pznw2ciu	308	38	ligase	ligase	NN
cord-016523-pznw2ciu	308	39	activity	activity	NN
cord-016523-pznw2ciu	308	40	of	of	IN
cord-016523-pznw2ciu	308	41	X	x	NN
cord-016523-pznw2ciu	308	42	-	-	HYPH
cord-016523-pznw2ciu	308	43	linked	link	VBN
cord-016523-pznw2ciu	308	44	inhibitor	inhibitor	NN
cord-016523-pznw2ciu	308	45	of	of	IN
cord-016523-pznw2ciu	308	46	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	308	47	protein	protein	NN
cord-016523-pznw2ciu	308	48	promotes	promote	VBZ
cord-016523-pznw2ciu	308	49	proteasomal	proteasomal	JJ
cord-016523-pznw2ciu	308	50	degradation	degradation	NN
cord-016523-pznw2ciu	308	51	of	of	IN
cord-016523-pznw2ciu	308	52	caspase-3	caspase-3	NNP
cord-016523-pznw2ciu	308	53	and	and	CC
cord-016523-pznw2ciu	308	54	enhances	enhance	VBZ
cord-016523-pznw2ciu	308	55	its	-PRON-	PRP$
cord-016523-pznw2ciu	308	56	anti	anti	JJ
cord-016523-pznw2ciu	308	57	-	-	JJ
cord-016523-pznw2ciu	308	58	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	308	59	effect	effect	NN
cord-016523-pznw2ciu	308	60	in	in	IN
cord-016523-pznw2ciu	308	61	Fas	Fas	NNP
cord-016523-pznw2ciu	308	62	-	-	HYPH
cord-016523-pznw2ciu	308	63	induced	induce	VBN
cord-016523-pznw2ciu	308	64	cell	cell	NN
cord-016523-pznw2ciu	308	65	death	death	NN
cord-016523-pznw2ciu	308	66	Smac	Smac	NNP
cord-016523-pznw2ciu	308	67	,	,	,
cord-016523-pznw2ciu	308	68	a	a	DT
cord-016523-pznw2ciu	308	69	mitochondrial	mitochondrial	JJ
cord-016523-pznw2ciu	308	70	protein	protein	NN
cord-016523-pznw2ciu	308	71	that	that	WDT
cord-016523-pznw2ciu	308	72	promotes	promote	VBZ
cord-016523-pznw2ciu	308	73	cytochrome	cytochrome	NN
cord-016523-pznw2ciu	308	74	c	c	NN
cord-016523-pznw2ciu	308	75	-	-	HYPH
cord-016523-pznw2ciu	308	76	dependent	dependent	JJ
cord-016523-pznw2ciu	308	77	caspase	caspase	NN
cord-016523-pznw2ciu	308	78	activation	activation	NN
cord-016523-pznw2ciu	308	79	by	by	IN
cord-016523-pznw2ciu	308	80	eliminating	eliminate	VBG
cord-016523-pznw2ciu	308	81	IAP	IAP	NNP
cord-016523-pznw2ciu	308	82	inhibition	inhibition	NN
cord-016523-pznw2ciu	308	83	Bcl-2	Bcl-2	NNP
cord-016523-pznw2ciu	308	84	and	and	CC
cord-016523-pznw2ciu	309	1	Bcl	Bcl	NNP
cord-016523-pznw2ciu	309	2	-	-	HYPH
cord-016523-pznw2ciu	309	3	xL	xL	NNP
cord-016523-pznw2ciu	309	4	inhibit	inhibit	NN
cord-016523-pznw2ciu	309	5	CD95-mediated	cd95-mediated	CD
cord-016523-pznw2ciu	309	6	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	309	7	by	by	IN
cord-016523-pznw2ciu	309	8	preventing	prevent	VBG
cord-016523-pznw2ciu	309	9	mitochondrial	mitochondrial	JJ
cord-016523-pznw2ciu	309	10	release	release	NN
cord-016523-pznw2ciu	309	11	of	of	IN
cord-016523-pznw2ciu	309	12	Smac	Smac	NNP
cord-016523-pznw2ciu	309	13	/	/	SYM
cord-016523-pznw2ciu	309	14	DIABLO	DIABLO	NNP
cord-016523-pznw2ciu	309	15	and	and	CC
cord-016523-pznw2ciu	309	16	subsequent	subsequent	JJ
cord-016523-pznw2ciu	309	17	inactivation	inactivation	NN
cord-016523-pznw2ciu	309	18	of	of	IN
cord-016523-pznw2ciu	309	19	X	x	NN
cord-016523-pznw2ciu	309	20	-	-	HYPH
cord-016523-pznw2ciu	309	21	linked	link	VBN
cord-016523-pznw2ciu	309	22	inhibitor	inhibitor	NN
cord-016523-pznw2ciu	309	23	-	-	HYPH
cord-016523-pznw2ciu	309	24	of	of	IN
cord-016523-pznw2ciu	309	25	-	-	HYPH
cord-016523-pznw2ciu	309	26	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	309	27	protein	protein	NN
cord-016523-pznw2ciu	309	28	Localization	localization	NN
cord-016523-pznw2ciu	309	29	of	of	IN
cord-016523-pznw2ciu	309	30	Fas	Fas	NNP
cord-016523-pznw2ciu	309	31	/	/	SYM
cord-016523-pznw2ciu	309	32	CD95	CD95	NNP
cord-016523-pznw2ciu	309	33	into	into	IN
cord-016523-pznw2ciu	309	34	the	the	DT
cord-016523-pznw2ciu	309	35	lipid	lipid	NN
cord-016523-pznw2ciu	309	36	rafts	raft	NNS
cord-016523-pznw2ciu	309	37	on	on	IN
cord-016523-pznw2ciu	309	38	down	down	IN
cord-016523-pznw2ciu	309	39	-	-	HYPH
cord-016523-pznw2ciu	309	40	modulation	modulation	NN
cord-016523-pznw2ciu	309	41	of	of	IN
cord-016523-pznw2ciu	309	42	the	the	DT
cord-016523-pznw2ciu	309	43	phosphatidylinositol	phosphatidylinositol	NN
cord-016523-pznw2ciu	309	44	3-kinase	3-kinase	CD
cord-016523-pznw2ciu	309	45	signaling	signal	VBG
cord-016523-pznw2ciu	309	46	pathway	pathway	NN
cord-016523-pznw2ciu	309	47	PTEN	PTEN	NNP
cord-016523-pznw2ciu	309	48	loss	loss	NN
cord-016523-pznw2ciu	309	49	promotes	promote	VBZ
cord-016523-pznw2ciu	309	50	mitochondrially	mitochondrially	RB
cord-016523-pznw2ciu	309	51	dependent	dependent	JJ
cord-016523-pznw2ciu	309	52	type	type	NN
cord-016523-pznw2ciu	309	53	II	II	NNP
cord-016523-pznw2ciu	309	54	Fas	Fas	NNP
cord-016523-pznw2ciu	309	55	-	-	HYPH
cord-016523-pznw2ciu	309	56	induced	induce	VBN
cord-016523-pznw2ciu	309	57	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	309	58	via	via	IN
cord-016523-pznw2ciu	310	1	PEA-15	PEA-15	NNP
cord-016523-pznw2ciu	310	2	Phosphatidylinositol	Phosphatidylinositol	NNP
cord-016523-pznw2ciu	310	3	3′-kinase	3′-kinase	CD
cord-016523-pznw2ciu	310	4	blocks	block	VBZ
cord-016523-pznw2ciu	310	5	CD95	CD95	NNP
cord-016523-pznw2ciu	310	6	aggregation	aggregation	NN
cord-016523-pznw2ciu	310	7	and	and	CC
cord-016523-pznw2ciu	310	8	caspase-8	caspase-8	JJ
cord-016523-pznw2ciu	310	9	cleavage	cleavage	NN
cord-016523-pznw2ciu	310	10	at	at	IN
cord-016523-pznw2ciu	310	11	the	the	DT
cord-016523-pznw2ciu	310	12	death	death	NN
cord-016523-pznw2ciu	310	13	-	-	HYPH
cord-016523-pznw2ciu	310	14	inducing	induce	VBG
cord-016523-pznw2ciu	310	15	signaling	signal	VBG
cord-016523-pznw2ciu	310	16	complex	complex	NN
cord-016523-pznw2ciu	310	17	by	by	IN
cord-016523-pznw2ciu	310	18	modulating	modulate	VBG
cord-016523-pznw2ciu	310	19	lateral	lateral	JJ
cord-016523-pznw2ciu	310	20	diffusion	diffusion	NN
cord-016523-pznw2ciu	310	21	of	of	IN
cord-016523-pznw2ciu	310	22	CD95	CD95	NNP
cord-016523-pznw2ciu	310	23	Actin	Actin	NNP
cord-016523-pznw2ciu	310	24	-	-	HYPH
cord-016523-pznw2ciu	310	25	independent	independent	JJ
cord-016523-pznw2ciu	310	26	exclusion	exclusion	NN
cord-016523-pznw2ciu	310	27	of	of	IN
cord-016523-pznw2ciu	310	28	CD95	CD95	NNP
cord-016523-pznw2ciu	310	29	by	by	IN
cord-016523-pznw2ciu	310	30	PI3K	PI3K	NNP
cord-016523-pznw2ciu	310	31	/	/	SYM
cord-016523-pznw2ciu	310	32	AKT	AKT	NNP
cord-016523-pznw2ciu	310	33	signalling	signalling	NN
cord-016523-pznw2ciu	310	34	:	:	:
cord-016523-pznw2ciu	310	35	implications	implication	NNS
cord-016523-pznw2ciu	310	36	for	for	IN
cord-016523-pznw2ciu	310	37	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	310	38	Phosphorylation	Phosphorylation	NNP
cord-016523-pznw2ciu	310	39	of	of	IN
cord-016523-pznw2ciu	310	40	PEA-15	PEA-15	NNP
cord-016523-pznw2ciu	310	41	switches	switch	VBZ
cord-016523-pznw2ciu	310	42	its	-PRON-	PRP$
cord-016523-pznw2ciu	310	43	binding	bind	VBG
cord-016523-pznw2ciu	310	44	specifi	specifi	NN
cord-016523-pznw2ciu	310	45	city	city	NN
cord-016523-pznw2ciu	310	46	from	from	IN
cord-016523-pznw2ciu	310	47	ERK	ERK	NNP
cord-016523-pznw2ciu	310	48	/	/	SYM
cord-016523-pznw2ciu	310	49	MAPK	MAPK	NNP
cord-016523-pznw2ciu	310	50	to	to	IN
cord-016523-pznw2ciu	310	51	FADD	FADD	NNP
cord-016523-pznw2ciu	310	52	Protein	Protein	NNP
cord-016523-pznw2ciu	311	1	kinase	kinase	NNP
cord-016523-pznw2ciu	311	2	B/	B/	NNP
cord-016523-pznw2ciu	312	1	Akt	Akt	NNP
cord-016523-pznw2ciu	312	2	binds	bind	VBZ
cord-016523-pznw2ciu	312	3	and	and	CC
cord-016523-pznw2ciu	312	4	phosphorylates	phosphorylate	VBZ
cord-016523-pznw2ciu	312	5	PED	PED	NNP
cord-016523-pznw2ciu	312	6	/	/	SYM
cord-016523-pznw2ciu	312	7	PEA-15	PEA-15	NNP
cord-016523-pznw2ciu	312	8	,	,	,
cord-016523-pznw2ciu	312	9	stabilizing	stabilize	VBG
cord-016523-pznw2ciu	312	10	its	-PRON-	PRP$
cord-016523-pznw2ciu	312	11	antiapoptotic	antiapoptotic	JJ
cord-016523-pznw2ciu	312	12	action	action	NN
cord-016523-pznw2ciu	312	13	Bcl-2	Bcl-2	NNP
cord-016523-pznw2ciu	312	14	and	and	CC
cord-016523-pznw2ciu	313	1	Fas	Fas	NNP
cord-016523-pznw2ciu	313	2	/	/	SYM
cord-016523-pznw2ciu	313	3	APO-1	APO-1	NNP
cord-016523-pznw2ciu	313	4	regulate	regulate	VBP
cord-016523-pznw2ciu	313	5	distinct	distinct	JJ
cord-016523-pznw2ciu	313	6	pathways	pathway	NNS
cord-016523-pznw2ciu	313	7	to	to	IN
cord-016523-pznw2ciu	313	8	lymphocyte	lymphocyte	NN
cord-016523-pznw2ciu	313	9	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	314	1	Bcl-2	Bcl-2	NNP
cord-016523-pznw2ciu	314	2	protects	protect	VBZ
cord-016523-pznw2ciu	314	3	from	from	IN
cord-016523-pznw2ciu	314	4	lethal	lethal	JJ
cord-016523-pznw2ciu	314	5	hepatic	hepatic	JJ
cord-016523-pznw2ciu	314	6	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	314	7	induced	induce	VBN
cord-016523-pznw2ciu	314	8	by	by	IN
cord-016523-pznw2ciu	314	9	an	an	DT
cord-016523-pznw2ciu	314	10	anti	anti	JJ
cord-016523-pznw2ciu	314	11	-	-	JJ
cord-016523-pznw2ciu	314	12	Fas	Fas	NNP
cord-016523-pznw2ciu	314	13	antibody	antibody	NN
cord-016523-pznw2ciu	314	14	in	in	IN
cord-016523-pznw2ciu	314	15	mice	mouse	NNS
cord-016523-pznw2ciu	315	1	A	a	DT
cord-016523-pznw2ciu	315	2	bcl-2	bcl-2	NN
cord-016523-pznw2ciu	315	3	transgene	transgene	NN
cord-016523-pznw2ciu	315	4	expressed	express	VBN
cord-016523-pznw2ciu	315	5	in	in	IN
cord-016523-pznw2ciu	315	6	hepatocytes	hepatocyte	NNS
cord-016523-pznw2ciu	315	7	protects	protect	VBZ
cord-016523-pznw2ciu	315	8	mice	mouse	NNS
cord-016523-pznw2ciu	315	9	from	from	IN
cord-016523-pznw2ciu	315	10	fulminant	fulminant	JJ
cord-016523-pznw2ciu	315	11	liver	liver	NN
cord-016523-pznw2ciu	315	12	destruction	destruction	NN
cord-016523-pznw2ciu	315	13	but	but	CC
cord-016523-pznw2ciu	315	14	not	not	RB
cord-016523-pznw2ciu	315	15	from	from	IN
cord-016523-pznw2ciu	315	16	rapid	rapid	JJ
cord-016523-pznw2ciu	315	17	death	death	NN
cord-016523-pznw2ciu	315	18	induced	induce	VBN
cord-016523-pznw2ciu	315	19	by	by	IN
cord-016523-pznw2ciu	315	20	anti	anti	JJ
cord-016523-pznw2ciu	315	21	-	-	JJ
cord-016523-pznw2ciu	315	22	Fas	Fas	NNP
cord-016523-pznw2ciu	315	23	antibody	antibody	NN
cord-016523-pznw2ciu	315	24	injection	injection	NN
cord-016523-pznw2ciu	315	25	Fas	Fas	NNP
cord-016523-pznw2ciu	315	26	gene	gene	NN
cord-016523-pznw2ciu	315	27	mutations	mutation	NNS
cord-016523-pznw2ciu	315	28	in	in	IN
cord-016523-pznw2ciu	315	29	the	the	DT
cord-016523-pznw2ciu	315	30	Canale	Canale	NNP
cord-016523-pznw2ciu	315	31	-	-	HYPH
cord-016523-pznw2ciu	315	32	Smith	Smith	NNP
cord-016523-pznw2ciu	315	33	syndrome	syndrome	NN
cord-016523-pznw2ciu	315	34	,	,	,
cord-016523-pznw2ciu	315	35	an	an	DT
cord-016523-pznw2ciu	315	36	inherited	inherit	VBN
cord-016523-pznw2ciu	315	37	lymphoproliferative	lymphoproliferative	JJ
cord-016523-pznw2ciu	315	38	disorder	disorder	NN
cord-016523-pznw2ciu	315	39	associated	associate	VBN
cord-016523-pznw2ciu	315	40	with	with	IN
cord-016523-pznw2ciu	315	41	autoimmunity	autoimmunity	NN
cord-016523-pznw2ciu	315	42	Dominant	dominant	JJ
cord-016523-pznw2ciu	315	43	interfering	interfere	VBG
cord-016523-pznw2ciu	315	44	Fas	Fas	NNP
cord-016523-pznw2ciu	315	45	gene	gene	NN
cord-016523-pznw2ciu	315	46	mutations	mutation	NNS
cord-016523-pznw2ciu	315	47	impair	impair	VBP
cord-016523-pznw2ciu	315	48	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	315	49	in	in	IN
cord-016523-pznw2ciu	315	50	a	a	DT
cord-016523-pznw2ciu	315	51	human	human	JJ
cord-016523-pznw2ciu	315	52	autoimmune	autoimmune	JJ
cord-016523-pznw2ciu	315	53	lymphoproliferative	lymphoproliferative	JJ
cord-016523-pznw2ciu	315	54	syndrome	syndrome	NN
cord-016523-pznw2ciu	315	55	Mutations	Mutations	NNPS
cord-016523-pznw2ciu	315	56	in	in	IN
cord-016523-pznw2ciu	315	57	Fas	Fas	NNP
cord-016523-pznw2ciu	315	58	associated	associate	VBN
cord-016523-pznw2ciu	315	59	with	with	IN
cord-016523-pznw2ciu	315	60	human	human	JJ
cord-016523-pznw2ciu	315	61	lymphoproliferative	lymphoproliferative	JJ
cord-016523-pznw2ciu	315	62	syndrome	syndrome	NN
cord-016523-pznw2ciu	315	63	and	and	CC
cord-016523-pznw2ciu	315	64	autoimmunity	autoimmunity	NN
cord-016523-pznw2ciu	316	1	Chronic	chronic	JJ
cord-016523-pznw2ciu	316	2	lymphadenopathy	lymphadenopathy	JJ
cord-016523-pznw2ciu	316	3	simulating	simulate	VBG
cord-016523-pznw2ciu	316	4	malignant	malignant	JJ
cord-016523-pznw2ciu	316	5	lymphoma	lymphoma	NN
cord-016523-pznw2ciu	316	6	Lymphoproliferative	lymphoproliferative	JJ
cord-016523-pznw2ciu	316	7	syndrome	syndrome	NN
cord-016523-pznw2ciu	316	8	with	with	IN
cord-016523-pznw2ciu	316	9	autoimmunity	autoimmunity	NN
cord-016523-pznw2ciu	316	10	:	:	:
cord-016523-pznw2ciu	316	11	a	a	DT
cord-016523-pznw2ciu	316	12	possible	possible	JJ
cord-016523-pznw2ciu	316	13	genetic	genetic	JJ
cord-016523-pznw2ciu	316	14	basis	basis	NN
cord-016523-pznw2ciu	316	15	for	for	IN
cord-016523-pznw2ciu	316	16	dominant	dominant	JJ
cord-016523-pznw2ciu	316	17	expression	expression	NN
cord-016523-pznw2ciu	316	18	of	of	IN
cord-016523-pznw2ciu	316	19	the	the	DT
cord-016523-pznw2ciu	316	20	clinical	clinical	JJ
cord-016523-pznw2ciu	316	21	manifestations	manifestation	NNS
cord-016523-pznw2ciu	317	1	The	the	DT
cord-016523-pznw2ciu	317	2	development	development	NN
cord-016523-pznw2ciu	317	3	of	of	IN
cord-016523-pznw2ciu	317	4	lymphomas	lymphoma	NNS
cord-016523-pznw2ciu	317	5	in	in	IN
cord-016523-pznw2ciu	317	6	families	family	NNS
cord-016523-pznw2ciu	317	7	with	with	IN
cord-016523-pznw2ciu	317	8	autoimmune	autoimmune	JJ
cord-016523-pznw2ciu	317	9	lymphoproliferative	lymphoproliferative	JJ
cord-016523-pznw2ciu	317	10	syndrome	syndrome	NN
cord-016523-pznw2ciu	317	11	with	with	IN
cord-016523-pznw2ciu	317	12	germline	germline	JJ
cord-016523-pznw2ciu	317	13	Fas	Fas	NNP
cord-016523-pznw2ciu	317	14	mutations	mutation	NNS
cord-016523-pznw2ciu	317	15	and	and	CC
cord-016523-pznw2ciu	317	16	defective	defective	JJ
cord-016523-pznw2ciu	317	17	lymphocyte	lymphocyte	NN
cord-016523-pznw2ciu	317	18	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	317	19	FLICE	FLICE	NNP
cord-016523-pznw2ciu	317	20	-	-	HYPH
cord-016523-pznw2ciu	317	21	inhibitory	inhibitory	JJ
cord-016523-pznw2ciu	317	22	protein	protein	NN
cord-016523-pznw2ciu	317	23	is	be	VBZ
cord-016523-pznw2ciu	317	24	a	a	DT
cord-016523-pznw2ciu	317	25	key	key	JJ
cord-016523-pznw2ciu	317	26	regulator	regulator	NN
cord-016523-pznw2ciu	317	27	of	of	IN
cord-016523-pznw2ciu	317	28	germinal	germinal	JJ
cord-016523-pznw2ciu	317	29	center	center	NN
cord-016523-pznw2ciu	317	30	B	B	NNP
cord-016523-pznw2ciu	317	31	cell	cell	NN
cord-016523-pznw2ciu	317	32	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	317	33	Primary	primary	JJ
cord-016523-pznw2ciu	317	34	diffuse	diffuse	VBP
cord-016523-pznw2ciu	317	35	large	large	JJ
cord-016523-pznw2ciu	317	36	B	b	NN
cord-016523-pznw2ciu	317	37	-	-	HYPH
cord-016523-pznw2ciu	317	38	cell	cell	NN
cord-016523-pznw2ciu	317	39	lymphomas	lymphoma	NNS
cord-016523-pznw2ciu	317	40	of	of	IN
cord-016523-pznw2ciu	317	41	the	the	DT
cord-016523-pznw2ciu	317	42	central	central	JJ
cord-016523-pznw2ciu	317	43	nervous	nervous	JJ
cord-016523-pznw2ciu	317	44	system	system	NN
cord-016523-pznw2ciu	317	45	are	be	VBP
cord-016523-pznw2ciu	317	46	targeted	target	VBN
cord-016523-pznw2ciu	317	47	by	by	IN
cord-016523-pznw2ciu	317	48	aberrant	aberrant	JJ
cord-016523-pznw2ciu	317	49	somatic	somatic	JJ
cord-016523-pznw2ciu	317	50	hypermutation	hypermutation	NN
cord-016523-pznw2ciu	318	1	The	the	DT
cord-016523-pznw2ciu	318	2	origin	origin	NN
cord-016523-pznw2ciu	318	3	of	of	IN
cord-016523-pznw2ciu	318	4	CD95-gene	CD95-gene	NNP
cord-016523-pznw2ciu	318	5	mutations	mutation	NNS
cord-016523-pznw2ciu	318	6	in	in	IN
cord-016523-pznw2ciu	318	7	B	b	NN
cord-016523-pznw2ciu	318	8	-	-	HYPH
cord-016523-pznw2ciu	318	9	cell	cell	NN
cord-016523-pznw2ciu	318	10	lymphoma	lymphoma	NN
cord-016523-pznw2ciu	319	1	Does	do	VBZ
cord-016523-pznw2ciu	319	2	CD95	CD95	NNP
cord-016523-pznw2ciu	319	3	have	have	VB
cord-016523-pznw2ciu	319	4	tumor	tumor	NN
cord-016523-pznw2ciu	319	5	promoting	promote	VBG
cord-016523-pznw2ciu	319	6	activities	activity	NNS
cord-016523-pznw2ciu	319	7	?	?	.
cord-016523-pznw2ciu	320	1	The	the	DT
cord-016523-pznw2ciu	320	2	relevance	relevance	NN
cord-016523-pznw2ciu	320	3	of	of	IN
cord-016523-pznw2ciu	320	4	NF	nf	NN
cord-016523-pznw2ciu	320	5	-	-	HYPH
cord-016523-pznw2ciu	320	6	kappaB	kappaB	NNP
cord-016523-pznw2ciu	320	7	for	for	IN
cord-016523-pznw2ciu	320	8	CD95	CD95	NNP
cord-016523-pznw2ciu	320	9	signaling	signal	VBG
cord-016523-pznw2ciu	320	10	in	in	IN
cord-016523-pznw2ciu	320	11	tumor	tumor	NN
cord-016523-pznw2ciu	320	12	cells	cell	NNS
cord-016523-pznw2ciu	320	13	Induction	induction	NN
cord-016523-pznw2ciu	320	14	of	of	IN
cord-016523-pznw2ciu	320	15	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	320	16	and	and	CC
cord-016523-pznw2ciu	320	17	activation	activation	NN
cord-016523-pznw2ciu	320	18	of	of	IN
cord-016523-pznw2ciu	320	19	NF	NF	NNP
cord-016523-pznw2ciu	320	20	-	-	HYPH
cord-016523-pznw2ciu	320	21	kappaB	kappaB	NNP
cord-016523-pznw2ciu	320	22	by	by	IN
cord-016523-pznw2ciu	320	23	CD95	CD95	NNP
cord-016523-pznw2ciu	320	24	require	require	VBP
cord-016523-pznw2ciu	320	25	different	different	JJ
cord-016523-pznw2ciu	320	26	signalling	signal	VBG
cord-016523-pznw2ciu	320	27	thresholds	threshold	NNS
cord-016523-pznw2ciu	320	28	CD95	CD95	NNP
cord-016523-pznw2ciu	320	29	ligand	ligand	NN
cord-016523-pznw2ciu	320	30	induces	induce	VBZ
cord-016523-pznw2ciu	320	31	motility	motility	NN
cord-016523-pznw2ciu	320	32	and	and	CC
cord-016523-pznw2ciu	320	33	invasiveness	invasiveness	NN
cord-016523-pznw2ciu	320	34	of	of	IN
cord-016523-pznw2ciu	320	35	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	320	36	-	-	HYPH
cord-016523-pznw2ciu	320	37	resistant	resistant	JJ
cord-016523-pznw2ciu	320	38	tumor	tumor	NN
cord-016523-pznw2ciu	320	39	cells	cell	NNS
cord-016523-pznw2ciu	321	1	CD95	CD95	NNP
cord-016523-pznw2ciu	321	2	signaling	signal	VBG
cord-016523-pznw2ciu	321	3	via	via	IN
cord-016523-pznw2ciu	321	4	ceramide	ceramide	NN
cord-016523-pznw2ciu	321	5	-	-	HYPH
cord-016523-pznw2ciu	321	6	rich	rich	JJ
cord-016523-pznw2ciu	321	7	membrane	membrane	NN
cord-016523-pznw2ciu	321	8	rafts	raft	NNS
cord-016523-pznw2ciu	322	1	Ligand	ligand	NN
cord-016523-pznw2ciu	322	2	-	-	HYPH
cord-016523-pznw2ciu	322	3	independent	independent	JJ
cord-016523-pznw2ciu	322	4	redistribution	redistribution	NN
cord-016523-pznw2ciu	322	5	of	of	IN
cord-016523-pznw2ciu	322	6	Fas	Fas	NNP
cord-016523-pznw2ciu	322	7	(	(	-LRB-
cord-016523-pznw2ciu	322	8	CD95	CD95	NNP
cord-016523-pznw2ciu	322	9	)	)	-RRB-
cord-016523-pznw2ciu	322	10	into	into	IN
cord-016523-pznw2ciu	322	11	lipid	lipid	NN
cord-016523-pznw2ciu	322	12	rafts	raft	NNS
cord-016523-pznw2ciu	322	13	mediates	mediate	VBZ
cord-016523-pznw2ciu	322	14	clonotypic	clonotypic	NNP
cord-016523-pznw2ciu	322	15	T	T	NNP
cord-016523-pznw2ciu	322	16	cell	cell	NN
cord-016523-pznw2ciu	322	17	death	death	NN
cord-016523-pznw2ciu	322	18	Fas	Fas	NNP
cord-016523-pznw2ciu	322	19	receptor	receptor	NN
cord-016523-pznw2ciu	322	20	clustering	clustering	NN
cord-016523-pznw2ciu	322	21	and	and	CC
cord-016523-pznw2ciu	322	22	involvement	involvement	NN
cord-016523-pznw2ciu	322	23	of	of	IN
cord-016523-pznw2ciu	322	24	the	the	DT
cord-016523-pznw2ciu	322	25	death	death	NN
cord-016523-pznw2ciu	322	26	receptor	receptor	NN
cord-016523-pznw2ciu	322	27	pathway	pathway	NN
cord-016523-pznw2ciu	322	28	in	in	IN
cord-016523-pznw2ciu	322	29	rituximabmediated	rituximabmediate	VBN
cord-016523-pznw2ciu	322	30	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	322	31	with	with	IN
cord-016523-pznw2ciu	322	32	concomitant	concomitant	JJ
cord-016523-pznw2ciu	322	33	sensitization	sensitization	NN
cord-016523-pznw2ciu	322	34	of	of	IN
cord-016523-pznw2ciu	322	35	lymphoma	lymphoma	NN
cord-016523-pznw2ciu	322	36	B	b	NN
cord-016523-pznw2ciu	322	37	cells	cell	NNS
cord-016523-pznw2ciu	322	38	to	to	IN
cord-016523-pznw2ciu	323	1	fas	fas	NNP
cord-016523-pznw2ciu	323	2	-	-	HYPH
cord-016523-pznw2ciu	323	3	induced	induce	VBN
cord-016523-pznw2ciu	323	4	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	324	1	Resveratrol	resveratrol	NN
cord-016523-pznw2ciu	324	2	-	-	HYPH
cord-016523-pznw2ciu	324	3	induced	induce	VBN
cord-016523-pznw2ciu	324	4	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	324	5	is	be	VBZ
cord-016523-pznw2ciu	324	6	associated	associate	VBN
cord-016523-pznw2ciu	324	7	with	with	IN
cord-016523-pznw2ciu	324	8	Fas	Fas	NNP
cord-016523-pznw2ciu	324	9	redistribution	redistribution	NN
cord-016523-pznw2ciu	324	10	in	in	IN
cord-016523-pznw2ciu	324	11	the	the	DT
cord-016523-pznw2ciu	324	12	rafts	raft	NNS
cord-016523-pznw2ciu	324	13	and	and	CC
cord-016523-pznw2ciu	324	14	the	the	DT
cord-016523-pznw2ciu	324	15	formation	formation	NN
cord-016523-pznw2ciu	324	16	of	of	IN
cord-016523-pznw2ciu	324	17	a	a	DT
cord-016523-pznw2ciu	324	18	death	death	NN
cord-016523-pznw2ciu	324	19	-	-	HYPH
cord-016523-pznw2ciu	324	20	inducing	induce	VBG
cord-016523-pznw2ciu	324	21	signaling	signal	VBG
cord-016523-pznw2ciu	324	22	complex	complex	NN
cord-016523-pznw2ciu	324	23	in	in	IN
cord-016523-pznw2ciu	324	24	colon	colon	NN
cord-016523-pznw2ciu	324	25	cancer	cancer	NN
cord-016523-pznw2ciu	324	26	cells	cell	NNS
cord-016523-pznw2ciu	324	27	Redistribution	redistribution	NN
cord-016523-pznw2ciu	324	28	of	of	IN
cord-016523-pznw2ciu	324	29	CD95	CD95	NNP
cord-016523-pznw2ciu	324	30	,	,	,
cord-016523-pznw2ciu	324	31	DR4	DR4	NNP
cord-016523-pznw2ciu	324	32	and	and	CC
cord-016523-pznw2ciu	324	33	DR5	DR5	NNP
cord-016523-pznw2ciu	324	34	in	in	IN
cord-016523-pznw2ciu	324	35	rafts	raft	NNS
cord-016523-pznw2ciu	324	36	accounts	account	VBZ
cord-016523-pznw2ciu	324	37	for	for	IN
cord-016523-pznw2ciu	324	38	the	the	DT
cord-016523-pznw2ciu	324	39	synergistic	synergistic	JJ
cord-016523-pznw2ciu	324	40	toxicity	toxicity	NN
cord-016523-pznw2ciu	324	41	of	of	IN
cord-016523-pznw2ciu	324	42	resveratrol	resveratrol	NN
cord-016523-pznw2ciu	324	43	and	and	CC
cord-016523-pznw2ciu	324	44	death	death	NN
cord-016523-pznw2ciu	324	45	receptor	receptor	NN
cord-016523-pznw2ciu	324	46	ligands	ligand	NNS
cord-016523-pznw2ciu	324	47	in	in	IN
cord-016523-pznw2ciu	324	48	colon	colon	NN
cord-016523-pznw2ciu	324	49	carcinoma	carcinoma	NN
cord-016523-pznw2ciu	324	50	cells	cell	NNS
cord-016523-pznw2ciu	325	1	Intracellular	Intracellular	NNP
cord-016523-pznw2ciu	325	2	triggering	trigger	VBG
cord-016523-pznw2ciu	325	3	of	of	IN
cord-016523-pznw2ciu	325	4	Fas	Fas	NNP
cord-016523-pznw2ciu	325	5	aggregation	aggregation	NN
cord-016523-pznw2ciu	325	6	and	and	CC
cord-016523-pznw2ciu	325	7	recruitment	recruitment	NN
cord-016523-pznw2ciu	325	8	of	of	IN
cord-016523-pznw2ciu	325	9	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	325	10	molecules	molecule	NNS
cord-016523-pznw2ciu	325	11	into	into	IN
cord-016523-pznw2ciu	325	12	Fas	Fas	NNP
cord-016523-pznw2ciu	325	13	-	-	HYPH
cord-016523-pznw2ciu	325	14	enriched	enrich	VBN
cord-016523-pznw2ciu	325	15	rafts	raft	NNS
cord-016523-pznw2ciu	325	16	in	in	IN
cord-016523-pznw2ciu	325	17	selective	selective	JJ
cord-016523-pznw2ciu	325	18	tumor	tumor	NN
cord-016523-pznw2ciu	325	19	cell	cell	NN
cord-016523-pznw2ciu	325	20	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	326	1	Edelfosine	edelfosine	NN
cord-016523-pznw2ciu	326	2	and	and	CC
cord-016523-pznw2ciu	326	3	perifosine	perifosine	NN
cord-016523-pznw2ciu	326	4	induce	induce	VBP
cord-016523-pznw2ciu	326	5	selective	selective	JJ
cord-016523-pznw2ciu	326	6	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	326	7	in	in	IN
cord-016523-pznw2ciu	326	8	multiple	multiple	JJ
cord-016523-pznw2ciu	326	9	myeloma	myeloma	NN
cord-016523-pznw2ciu	326	10	by	by	IN
cord-016523-pznw2ciu	326	11	recruitment	recruitment	NN
cord-016523-pznw2ciu	326	12	of	of	IN
cord-016523-pznw2ciu	326	13	death	death	NN
cord-016523-pznw2ciu	326	14	receptors	receptor	NNS
cord-016523-pznw2ciu	326	15	and	and	CC
cord-016523-pznw2ciu	326	16	downstream	downstream	JJ
cord-016523-pznw2ciu	326	17	signaling	signal	VBG
cord-016523-pznw2ciu	326	18	molecules	molecule	NNS
cord-016523-pznw2ciu	326	19	into	into	IN
cord-016523-pznw2ciu	326	20	lipid	lipid	NN
cord-016523-pznw2ciu	326	21	rafts	raft	NNS
cord-016523-pznw2ciu	327	1	Cytoskeleton	Cytoskeleton	NNP
cord-016523-pznw2ciu	327	2	-	-	HYPH
cord-016523-pznw2ciu	327	3	mediated	mediate	VBN
cord-016523-pznw2ciu	327	4	death	death	NN
cord-016523-pznw2ciu	327	5	receptor	receptor	NN
cord-016523-pznw2ciu	327	6	and	and	CC
cord-016523-pznw2ciu	327	7	ligand	ligand	NN
cord-016523-pznw2ciu	327	8	concentration	concentration	NN
cord-016523-pznw2ciu	327	9	in	in	IN
cord-016523-pznw2ciu	327	10	lipid	lipid	NN
cord-016523-pznw2ciu	327	11	rafts	raft	NNS
cord-016523-pznw2ciu	327	12	forms	form	VBZ
cord-016523-pznw2ciu	327	13	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	327	14	-	-	HYPH
cord-016523-pznw2ciu	327	15	promoting	promote	VBG
cord-016523-pznw2ciu	327	16	clusters	cluster	NNS
cord-016523-pznw2ciu	327	17	in	in	IN
cord-016523-pznw2ciu	327	18	cancer	cancer	NN
cord-016523-pznw2ciu	328	1	chemotherapy	chemotherapy	NN
cord-016523-pznw2ciu	329	1	Cisplatin	cisplatin	NN
cord-016523-pznw2ciu	329	2	-	-	HYPH
cord-016523-pznw2ciu	329	3	induced	induce	VBN
cord-016523-pznw2ciu	329	4	CD95	CD95	NNP
cord-016523-pznw2ciu	329	5	redistribution	redistribution	NN
cord-016523-pznw2ciu	329	6	into	into	IN
cord-016523-pznw2ciu	329	7	membrane	membrane	NN
cord-016523-pznw2ciu	329	8	lipid	lipid	NN
cord-016523-pznw2ciu	329	9	rafts	raft	NNS
cord-016523-pznw2ciu	329	10	of	of	IN
cord-016523-pznw2ciu	329	11	HT29	HT29	NNP
cord-016523-pznw2ciu	329	12	human	human	JJ
cord-016523-pznw2ciu	329	13	colon	colon	NN
cord-016523-pznw2ciu	329	14	cancer	cancer	NN
cord-016523-pznw2ciu	329	15	cells	cell	NNS
cord-016523-pznw2ciu	329	16	Redistribution	redistribution	NN
cord-016523-pznw2ciu	329	17	of	of	IN
cord-016523-pznw2ciu	329	18	CD95	CD95	NNP
cord-016523-pznw2ciu	329	19	into	into	IN
cord-016523-pznw2ciu	329	20	the	the	DT
cord-016523-pznw2ciu	329	21	lipid	lipid	NN
cord-016523-pznw2ciu	329	22	rafts	raft	NNS
cord-016523-pznw2ciu	329	23	to	to	TO
cord-016523-pznw2ciu	329	24	treat	treat	VB
cord-016523-pznw2ciu	329	25	cancer	cancer	NN
cord-016523-pznw2ciu	329	26	cells	cell	NNS
cord-016523-pznw2ciu	329	27	?	?	.
cord-016523-pznw2ciu	330	1	Redox	redox	NN
cord-016523-pznw2ciu	330	2	amplifi	amplifi	NNP
cord-016523-pznw2ciu	330	3	cation	cation	NN
cord-016523-pznw2ciu	330	4	of	of	IN
cord-016523-pznw2ciu	330	5	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	330	6	by	by	IN
cord-016523-pznw2ciu	330	7	caspase	caspase	NN
cord-016523-pznw2ciu	330	8	-	-	HYPH
cord-016523-pznw2ciu	330	9	dependent	dependent	JJ
cord-016523-pznw2ciu	330	10	cleavage	cleavage	NN
cord-016523-pznw2ciu	330	11	of	of	IN
cord-016523-pznw2ciu	330	12	glutaredoxin	glutaredoxin	NNP
cord-016523-pznw2ciu	330	13	1	1	CD
cord-016523-pznw2ciu	330	14	and	and	CC
cord-016523-pznw2ciu	330	15	S	s	NN
cord-016523-pznw2ciu	330	16	-	-	HYPH
cord-016523-pznw2ciu	330	17	glutathionylation	glutathionylation	NN
cord-016523-pznw2ciu	330	18	of	of	IN
cord-016523-pznw2ciu	330	19	Fas	Fas	NNP
cord-016523-pznw2ciu	330	20	Purifi	Purifi	NNP
cord-016523-pznw2ciu	330	21	cation	cation	NN
cord-016523-pznw2ciu	330	22	and	and	CC
cord-016523-pznw2ciu	330	23	molecular	molecular	JJ
cord-016523-pznw2ciu	330	24	cloning	cloning	NN
cord-016523-pznw2ciu	330	25	of	of	IN
cord-016523-pznw2ciu	330	26	the	the	DT
cord-016523-pznw2ciu	330	27	APO-1	APO-1	NNP
cord-016523-pznw2ciu	330	28	cell	cell	NN
cord-016523-pznw2ciu	330	29	surface	surface	NN
cord-016523-pznw2ciu	330	30	antigen	antigen	NN
cord-016523-pznw2ciu	330	31	,	,	,
cord-016523-pznw2ciu	330	32	a	a	DT
cord-016523-pznw2ciu	330	33	member	member	NN
cord-016523-pznw2ciu	330	34	of	of	IN
cord-016523-pznw2ciu	330	35	the	the	DT
cord-016523-pznw2ciu	330	36	tumor	tumor	NN
cord-016523-pznw2ciu	330	37	necrosis	necrosis	NN
cord-016523-pznw2ciu	330	38	factor	factor	NN
cord-016523-pznw2ciu	330	39	/	/	SYM
cord-016523-pznw2ciu	330	40	nerve	nerve	NN
cord-016523-pznw2ciu	330	41	growth	growth	NN
cord-016523-pznw2ciu	330	42	factor	factor	NN
cord-016523-pznw2ciu	330	43	receptor	receptor	NN
cord-016523-pznw2ciu	330	44	superfamily	superfamily	NN
cord-016523-pznw2ciu	330	45	.	.	.
cord-016523-pznw2ciu	331	1	Sequence	sequence	NN
cord-016523-pznw2ciu	331	2	identity	identity	NN
cord-016523-pznw2ciu	331	3	with	with	IN
cord-016523-pznw2ciu	331	4	the	the	DT
cord-016523-pznw2ciu	331	5	Fas	Fas	NNP
cord-016523-pznw2ciu	331	6	antigen	antigen	NN
cord-016523-pznw2ciu	331	7	Ceramide	Ceramide	NNP
cord-016523-pznw2ciu	331	8	-	-	HYPH
cord-016523-pznw2ciu	331	9	mediated	mediate	VBN
cord-016523-pznw2ciu	331	10	clustering	clustering	NN
cord-016523-pznw2ciu	331	11	is	be	VBZ
cord-016523-pznw2ciu	331	12	required	require	VBN
cord-016523-pznw2ciu	331	13	for	for	IN
cord-016523-pznw2ciu	331	14	CD95-DISC	CD95-DISC	NNP
cord-016523-pznw2ciu	331	15	formation	formation	NN
cord-016523-pznw2ciu	331	16	S	s	NN
cord-016523-pznw2ciu	331	17	-	-	HYPH
cord-016523-pznw2ciu	331	18	glutathionylation	glutathionylation	NNP
cord-016523-pznw2ciu	331	19	uncouples	uncouple	NNS
cord-016523-pznw2ciu	331	20	eNOS	eNOS	NNP
cord-016523-pznw2ciu	331	21	and	and	CC
cord-016523-pznw2ciu	331	22	regulates	regulate	VBZ
cord-016523-pznw2ciu	331	23	its	-PRON-	PRP$
cord-016523-pznw2ciu	331	24	cellular	cellular	JJ
cord-016523-pznw2ciu	331	25	and	and	CC
cord-016523-pznw2ciu	331	26	vascular	vascular	JJ
cord-016523-pznw2ciu	331	27	function	function	NN
cord-016523-pznw2ciu	331	28	S	s	NN
cord-016523-pznw2ciu	331	29	-	-	HYPH
cord-016523-pznw2ciu	331	30	nitrosylation	nitrosylation	NN
cord-016523-pznw2ciu	331	31	of	of	IN
cord-016523-pznw2ciu	331	32	the	the	DT
cord-016523-pznw2ciu	331	33	death	death	NN
cord-016523-pznw2ciu	331	34	receptor	receptor	NN
cord-016523-pznw2ciu	331	35	fas	fas	NNP
cord-016523-pznw2ciu	331	36	promotes	promote	VBZ
cord-016523-pznw2ciu	331	37	fas	fas	NNP
cord-016523-pznw2ciu	331	38	ligand	ligand	NN
cord-016523-pznw2ciu	331	39	-	-	HYPH
cord-016523-pznw2ciu	331	40	mediated	mediate	VBN
cord-016523-pznw2ciu	331	41	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	331	42	in	in	IN
cord-016523-pznw2ciu	331	43	cancer	cancer	NN
cord-016523-pznw2ciu	331	44	cells	cell	NNS
cord-016523-pznw2ciu	332	1	Palmitoylation	Palmitoylation	NNP
cord-016523-pznw2ciu	332	2	is	be	VBZ
cord-016523-pznw2ciu	332	3	required	require	VBN
cord-016523-pznw2ciu	332	4	for	for	IN
cord-016523-pznw2ciu	332	5	effi	effi	NNP
cord-016523-pznw2ciu	332	6	cient	cient	NNP
cord-016523-pznw2ciu	332	7	Fas	Fas	NNP
cord-016523-pznw2ciu	332	8	cell	cell	NN
cord-016523-pznw2ciu	332	9	death	death	NN
cord-016523-pznw2ciu	332	10	signaling	signal	VBG
cord-016523-pznw2ciu	332	11	Palmitoylation	Palmitoylation	NNP
cord-016523-pznw2ciu	332	12	of	of	IN
cord-016523-pznw2ciu	332	13	CD95	CD95	NNP
cord-016523-pznw2ciu	332	14	facilitates	facilitate	VBZ
cord-016523-pznw2ciu	332	15	formation	formation	NN
cord-016523-pznw2ciu	332	16	of	of	IN
cord-016523-pznw2ciu	332	17	SDS	sds	NN
cord-016523-pznw2ciu	332	18	-	-	HYPH
cord-016523-pznw2ciu	332	19	stable	stable	JJ
cord-016523-pznw2ciu	332	20	receptor	receptor	NN
cord-016523-pznw2ciu	332	21	aggregates	aggregate	NNS
cord-016523-pznw2ciu	332	22	that	that	WDT
cord-016523-pznw2ciu	332	23	initiate	initiate	VBP
cord-016523-pznw2ciu	332	24	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	332	25	signaling	signal	VBG
cord-016523-pznw2ciu	332	26	The	the	DT
cord-016523-pznw2ciu	332	27	role	role	NN
cord-016523-pznw2ciu	332	28	of	of	IN
cord-016523-pznw2ciu	332	29	receptor	receptor	NN
cord-016523-pznw2ciu	332	30	internalization	internalization	NN
cord-016523-pznw2ciu	332	31	in	in	IN
cord-016523-pznw2ciu	332	32	CD95	CD95	NNP
cord-016523-pznw2ciu	332	33	signaling	signal	VBG
cord-016523-pznw2ciu	332	34	CD95	CD95	NNP
cord-016523-pznw2ciu	332	35	triggers	trigger	VBZ
cord-016523-pznw2ciu	332	36	Orai1-mediated	Orai1-mediated	NNP
cord-016523-pznw2ciu	332	37	localized	localize	VBN
cord-016523-pznw2ciu	332	38	Ca2	ca2	NN
cord-016523-pznw2ciu	332	39	+	+	CC
cord-016523-pznw2ciu	332	40	entry	entry	NN
cord-016523-pznw2ciu	332	41	,	,	,
cord-016523-pznw2ciu	332	42	regulates	regulate	VBZ
cord-016523-pznw2ciu	332	43	recruitment	recruitment	NN
cord-016523-pznw2ciu	332	44	of	of	IN
cord-016523-pznw2ciu	332	45	protein	protein	NN
cord-016523-pznw2ciu	332	46	kinase	kinase	NN
cord-016523-pznw2ciu	332	47	C	C	NNP
cord-016523-pznw2ciu	332	48	(	(	-LRB-
cord-016523-pznw2ciu	332	49	PKC	PKC	NNP
cord-016523-pznw2ciu	332	50	)	)	-RRB-
cord-016523-pznw2ciu	332	51	beta2	beta2	NN
cord-016523-pznw2ciu	332	52	,	,	,
cord-016523-pznw2ciu	332	53	and	and	CC
cord-016523-pznw2ciu	332	54	prevents	prevent	VBZ
cord-016523-pznw2ciu	332	55	deathinducing	deathinduce	VBG
cord-016523-pznw2ciu	332	56	signaling	signal	VBG
cord-016523-pznw2ciu	332	57	complex	complex	JJ
cord-016523-pznw2ciu	332	58	formation	formation	NN
cord-016523-pznw2ciu	333	1	The	the	DT
cord-016523-pznw2ciu	333	2	CD95	CD95	NNP
cord-016523-pznw2ciu	333	3	signaling	signal	VBG
cord-016523-pznw2ciu	333	4	pathway	pathway	NN
cord-016523-pznw2ciu	333	5	:	:	:
cord-016523-pznw2ciu	333	6	to	to	TO
cord-016523-pznw2ciu	333	7	not	not	RB
cord-016523-pznw2ciu	333	8	die	die	VB
cord-016523-pznw2ciu	333	9	and	and	CC
cord-016523-pznw2ciu	333	10	fl	fl	JJ
cord-016523-pznw2ciu	333	11	RIP	rip	NN
cord-016523-pznw2ciu	333	12	:	:	:
cord-016523-pznw2ciu	334	1	a	a	DT
cord-016523-pznw2ciu	334	2	novel	novel	JJ
cord-016523-pznw2ciu	334	3	protein	protein	NN
cord-016523-pznw2ciu	334	4	containing	contain	VBG
cord-016523-pznw2ciu	334	5	a	a	DT
cord-016523-pznw2ciu	334	6	death	death	NN
cord-016523-pznw2ciu	334	7	domain	domain	NN
cord-016523-pznw2ciu	334	8	that	that	WDT
cord-016523-pznw2ciu	334	9	interacts	interact	VBZ
cord-016523-pznw2ciu	334	10	with	with	IN
cord-016523-pznw2ciu	334	11	Fas	Fas	NNP
cord-016523-pznw2ciu	334	12	/	/	SYM
cord-016523-pznw2ciu	334	13	APO-1	APO-1	NNP
cord-016523-pznw2ciu	334	14	(	(	-LRB-
cord-016523-pznw2ciu	334	15	CD95	CD95	NNP
cord-016523-pznw2ciu	334	16	)	)	-RRB-
cord-016523-pznw2ciu	334	17	in	in	IN
cord-016523-pznw2ciu	334	18	yeast	yeast	NN
cord-016523-pznw2ciu	334	19	and	and	CC
cord-016523-pznw2ciu	334	20	causes	cause	VBZ
cord-016523-pznw2ciu	334	21	cell	cell	NN
cord-016523-pznw2ciu	334	22	death	death	NN
cord-016523-pznw2ciu	334	23	Chemical	Chemical	NNP
cord-016523-pznw2ciu	334	24	inhibitor	inhibitor	NN
cord-016523-pznw2ciu	334	25	of	of	IN
cord-016523-pznw2ciu	334	26	nonapoptotic	nonapoptotic	JJ
cord-016523-pznw2ciu	334	27	cell	cell	NN
cord-016523-pznw2ciu	334	28	death	death	NN
cord-016523-pznw2ciu	334	29	with	with	IN
cord-016523-pznw2ciu	334	30	therapeutic	therapeutic	JJ
cord-016523-pznw2ciu	334	31	potential	potential	NN
cord-016523-pznw2ciu	334	32	for	for	IN
cord-016523-pznw2ciu	334	33	ischemic	ischemic	JJ
cord-016523-pznw2ciu	334	34	brain	brain	NN
cord-016523-pznw2ciu	334	35	injury	injury	NN
cord-016523-pznw2ciu	334	36	Identifi	Identifi	NNP
cord-016523-pznw2ciu	334	37	cation	cation	NN
cord-016523-pznw2ciu	334	38	of	of	IN
cord-016523-pznw2ciu	334	39	RIP1	RIP1	NNP
cord-016523-pznw2ciu	334	40	kinase	kinase	NNP
cord-016523-pznw2ciu	334	41	as	as	IN
cord-016523-pznw2ciu	334	42	a	a	DT
cord-016523-pznw2ciu	334	43	specifi	specifi	NN
cord-016523-pznw2ciu	334	44	c	c	NN
cord-016523-pznw2ciu	334	45	cellular	cellular	JJ
cord-016523-pznw2ciu	334	46	target	target	NN
cord-016523-pznw2ciu	334	47	of	of	IN
cord-016523-pznw2ciu	334	48	necrostatins	necrostatins	NNP
cord-016523-pznw2ciu	335	1	The	the	DT
cord-016523-pznw2ciu	335	2	roles	role	NNS
cord-016523-pznw2ciu	335	3	of	of	IN
cord-016523-pznw2ciu	335	4	FADD	FADD	NNP
cord-016523-pznw2ciu	335	5	in	in	IN
cord-016523-pznw2ciu	335	6	extrinsic	extrinsic	JJ
cord-016523-pznw2ciu	335	7	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	335	8	and	and	CC
cord-016523-pznw2ciu	335	9	necroptosis	necroptosis	NN
cord-016523-pznw2ciu	335	10	Cleavage	cleavage	NN
cord-016523-pznw2ciu	335	11	of	of	IN
cord-016523-pznw2ciu	335	12	the	the	DT
cord-016523-pznw2ciu	335	13	death	death	NN
cord-016523-pznw2ciu	335	14	domain	domain	NN
cord-016523-pznw2ciu	335	15	kinase	kinase	NN
cord-016523-pznw2ciu	335	16	RIP	RIP	NNP
cord-016523-pznw2ciu	335	17	by	by	IN
cord-016523-pznw2ciu	335	18	caspase-8	caspase-8	NNP
cord-016523-pznw2ciu	335	19	prompts	prompt	NNS
cord-016523-pznw2ciu	336	1	TNF	TNF	NNP
cord-016523-pznw2ciu	336	2	-	-	HYPH
cord-016523-pznw2ciu	336	3	induced	induce	VBN
cord-016523-pznw2ciu	336	4	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	336	5	Cleavage	cleavage	NN
cord-016523-pznw2ciu	336	6	of	of	IN
cord-016523-pznw2ciu	336	7	RIP3	RIP3	NNP
cord-016523-pznw2ciu	336	8	inactivates	inactivate	VBZ
cord-016523-pznw2ciu	336	9	its	-PRON-	PRP$
cord-016523-pznw2ciu	336	10	caspaseindependent	caspaseindependent	NN
cord-016523-pznw2ciu	336	11	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	336	12	pathway	pathway	NN
cord-016523-pznw2ciu	336	13	by	by	IN
cord-016523-pznw2ciu	336	14	removal	removal	NN
cord-016523-pznw2ciu	336	15	of	of	IN
cord-016523-pznw2ciu	336	16	kinase	kinase	NN
cord-016523-pznw2ciu	336	17	domain	domain	NN
cord-016523-pznw2ciu	336	18	Caspase	Caspase	NNP
cord-016523-pznw2ciu	336	19	8	8	CD
cord-016523-pznw2ciu	337	1	inhibits	inhibit	NNS
cord-016523-pznw2ciu	337	2	programmed	programmed	JJ
cord-016523-pznw2ciu	337	3	necrosis	necrosis	NN
cord-016523-pznw2ciu	337	4	by	by	IN
cord-016523-pznw2ciu	337	5	processing	process	VBG
cord-016523-pznw2ciu	337	6	CYLD	CYLD	NNP
cord-016523-pznw2ciu	337	7	Programmed	program	VBD
cord-016523-pznw2ciu	337	8	cell	cell	NN
cord-016523-pznw2ciu	337	9	death	death	NN
cord-016523-pznw2ciu	337	10	:	:	:
cord-016523-pznw2ciu	337	11	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	337	12	meets	meet	VBZ
cord-016523-pznw2ciu	337	13	necrosis	necrosis	NN
cord-016523-pznw2ciu	337	14	Fas	Fas	NNP
cord-016523-pznw2ciu	337	15	involvement	involvement	NN
cord-016523-pznw2ciu	337	16	in	in	IN
cord-016523-pznw2ciu	337	17	cytotoxicity	cytotoxicity	NN
cord-016523-pznw2ciu	337	18	mediated	mediate	VBN
cord-016523-pznw2ciu	337	19	by	by	IN
cord-016523-pznw2ciu	337	20	human	human	JJ
cord-016523-pznw2ciu	337	21	NK	NK	NNP
cord-016523-pznw2ciu	337	22	cells	cell	NNS
cord-016523-pznw2ciu	337	23	Fas	Fas	NNP
cord-016523-pznw2ciu	337	24	ligand	ligand	NN
cord-016523-pznw2ciu	337	25	expression	expression	NN
cord-016523-pznw2ciu	337	26	by	by	IN
cord-016523-pznw2ciu	337	27	astrocytoma	astrocytoma	NN
cord-016523-pznw2ciu	337	28	in	in	IN
cord-016523-pznw2ciu	337	29	vivo	vivo	NN
cord-016523-pznw2ciu	337	30	:	:	:
cord-016523-pznw2ciu	337	31	maintaining	maintain	VBG
cord-016523-pznw2ciu	337	32	immune	immune	JJ
cord-016523-pznw2ciu	337	33	privilege	privilege	NN
cord-016523-pznw2ciu	337	34	in	in	IN
cord-016523-pznw2ciu	337	35	the	the	DT
cord-016523-pznw2ciu	337	36	brain	brain	NN
cord-016523-pznw2ciu	337	37	?	?	.
cord-016523-pznw2ciu	338	1	CD95	CD95	NNP
cord-016523-pznw2ciu	338	2	ligand	ligand	NN
cord-016523-pznw2ciu	338	3	(	(	-LRB-
cord-016523-pznw2ciu	338	4	FasL)-induced	fasl)-induce	VBN
cord-016523-pznw2ciu	338	5	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	338	6	is	be	VBZ
cord-016523-pznw2ciu	338	7	necessary	necessary	JJ
cord-016523-pznw2ciu	338	8	for	for	IN
cord-016523-pznw2ciu	338	9	corneal	corneal	JJ
cord-016523-pznw2ciu	338	10	allograft	allograft	NN
cord-016523-pznw2ciu	338	11	survival	survival	NN
cord-016523-pznw2ciu	338	12	Melanoma	Melanoma	NNP
cord-016523-pznw2ciu	338	13	cell	cell	NN
cord-016523-pznw2ciu	338	14	expression	expression	NN
cord-016523-pznw2ciu	338	15	of	of	IN
cord-016523-pznw2ciu	338	16	Fas(Apo-1	Fas(Apo-1	NNP
cord-016523-pznw2ciu	338	17	/	/	SYM
cord-016523-pznw2ciu	338	18	CD95	CD95	NNP
cord-016523-pznw2ciu	338	19	)	)	-RRB-
cord-016523-pznw2ciu	338	20	ligand	ligand	NN
cord-016523-pznw2ciu	338	21	:	:	:
cord-016523-pznw2ciu	338	22	implications	implication	NNS
cord-016523-pznw2ciu	338	23	for	for	IN
cord-016523-pznw2ciu	338	24	tumor	tumor	NN
cord-016523-pznw2ciu	338	25	immune	immune	JJ
cord-016523-pznw2ciu	338	26	escape	escape	NN
cord-016523-pznw2ciu	339	1	The	the	DT
cord-016523-pznw2ciu	339	2	Fas	Fas	NNP
cord-016523-pznw2ciu	339	3	counterattack	counterattack	NN
cord-016523-pznw2ciu	339	4	:	:	:
cord-016523-pznw2ciu	339	5	Fasmediated	Fasmediated	NNP
cord-016523-pznw2ciu	339	6	T	T	NNP
cord-016523-pznw2ciu	339	7	cell	cell	NN
cord-016523-pznw2ciu	339	8	killing	kill	VBG
cord-016523-pznw2ciu	339	9	by	by	IN
cord-016523-pznw2ciu	339	10	colon	colon	NN
cord-016523-pznw2ciu	339	11	cancer	cancer	NN
cord-016523-pznw2ciu	339	12	cells	cell	NNS
cord-016523-pznw2ciu	339	13	expressing	express	VBG
cord-016523-pznw2ciu	339	14	Fas	Fas	NNP
cord-016523-pznw2ciu	339	15	ligand	ligand	NN
cord-016523-pznw2ciu	339	16	Transgenic	transgenic	JJ
cord-016523-pznw2ciu	339	17	expression	expression	NN
cord-016523-pznw2ciu	339	18	of	of	IN
cord-016523-pznw2ciu	339	19	CD95	CD95	NNP
cord-016523-pznw2ciu	339	20	ligand	ligand	NN
cord-016523-pznw2ciu	339	21	on	on	IN
cord-016523-pznw2ciu	339	22	islet	islet	NN
cord-016523-pznw2ciu	340	1	beta	beta	NN
cord-016523-pznw2ciu	340	2	cells	cell	NNS
cord-016523-pznw2ciu	340	3	induces	induce	VBZ
cord-016523-pznw2ciu	340	4	a	a	DT
cord-016523-pznw2ciu	340	5	granulocytic	granulocytic	JJ
cord-016523-pznw2ciu	340	6	infi	infi	NNP
cord-016523-pznw2ciu	340	7	ltration	ltration	NN
cord-016523-pznw2ciu	340	8	but	but	CC
cord-016523-pznw2ciu	340	9	does	do	VBZ
cord-016523-pznw2ciu	340	10	not	not	RB
cord-016523-pznw2ciu	340	11	confer	confer	VB
cord-016523-pznw2ciu	340	12	immune	immune	JJ
cord-016523-pznw2ciu	340	13	privilege	privilege	NN
cord-016523-pznw2ciu	340	14	upon	upon	IN
cord-016523-pznw2ciu	340	15	islet	islet	NN
cord-016523-pznw2ciu	340	16	allografts	allografts	NNP
cord-016523-pznw2ciu	340	17	Fas	Fas	NNP
cord-016523-pznw2ciu	340	18	ligand	ligand	NN
cord-016523-pznw2ciu	340	19	expression	expression	NN
cord-016523-pznw2ciu	340	20	in	in	IN
cord-016523-pznw2ciu	340	21	islets	islet	NNS
cord-016523-pznw2ciu	340	22	of	of	IN
cord-016523-pznw2ciu	340	23	Langerhans	Langerhans	NNP
cord-016523-pznw2ciu	340	24	does	do	VBZ
cord-016523-pznw2ciu	340	25	not	not	RB
cord-016523-pznw2ciu	340	26	confer	confer	VB
cord-016523-pznw2ciu	340	27	immune	immune	JJ
cord-016523-pznw2ciu	340	28	privilege	privilege	NN
cord-016523-pznw2ciu	340	29	and	and	CC
cord-016523-pznw2ciu	340	30	instead	instead	RB
cord-016523-pznw2ciu	340	31	targets	target	VBZ
cord-016523-pznw2ciu	340	32	them	-PRON-	PRP
cord-016523-pznw2ciu	340	33	for	for	IN
cord-016523-pznw2ciu	340	34	rapid	rapid	JJ
cord-016523-pznw2ciu	340	35	destruction	destruction	NN
cord-016523-pznw2ciu	340	36	Regulation	regulation	NN
cord-016523-pznw2ciu	340	37	of	of	IN
cord-016523-pznw2ciu	340	38	the	the	DT
cord-016523-pznw2ciu	340	39	proinfl	proinfl	NN
cord-016523-pznw2ciu	340	40	ammatory	ammatory	NN
cord-016523-pznw2ciu	340	41	effects	effect	NNS
cord-016523-pznw2ciu	340	42	of	of	IN
cord-016523-pznw2ciu	340	43	Fas	Fas	NNP
cord-016523-pznw2ciu	340	44	ligand	ligand	NN
cord-016523-pznw2ciu	340	45	(	(	-LRB-
cord-016523-pznw2ciu	340	46	CD95L	cd95l	NN
cord-016523-pznw2ciu	340	47	)	)	-RRB-
cord-016523-pznw2ciu	341	1	Cancer	cancer	NN
cord-016523-pznw2ciu	341	2	immunosurveillance	immunosurveillance	NN
cord-016523-pznw2ciu	341	3	,	,	,
cord-016523-pznw2ciu	341	4	immunoediting	immunoediting	NN
cord-016523-pznw2ciu	341	5	and	and	CC
cord-016523-pznw2ciu	341	6	infl	infl	NNP
cord-016523-pznw2ciu	341	7	ammation	ammation	NNP
cord-016523-pznw2ciu	341	8	:	:	:
cord-016523-pznw2ciu	341	9	independent	independent	JJ
cord-016523-pznw2ciu	341	10	or	or	CC
cord-016523-pznw2ciu	341	11	interdependent	interdependent	JJ
cord-016523-pznw2ciu	341	12	processes	process	NNS
cord-016523-pznw2ciu	341	13	?	?	.
cord-016523-pznw2ciu	342	1	Dominant	dominant	JJ
cord-016523-pznw2ciu	342	2	-	-	HYPH
cord-016523-pznw2ciu	342	3	negative	negative	JJ
cord-016523-pznw2ciu	342	4	Fas	Fas	NNP
cord-016523-pznw2ciu	342	5	mutation	mutation	NN
cord-016523-pznw2ciu	342	6	is	be	VBZ
cord-016523-pznw2ciu	342	7	reversed	reverse	VBN
cord-016523-pznw2ciu	342	8	by	by	IN
cord-016523-pznw2ciu	342	9	down	down	NN
cord-016523-pznw2ciu	342	10	-	-	HYPH
cord-016523-pznw2ciu	342	11	expression	expression	NN
cord-016523-pznw2ciu	342	12	of	of	IN
cord-016523-pznw2ciu	342	13	c	c	NN
cord-016523-pznw2ciu	342	14	-	-	:
cord-016523-pznw2ciu	342	15	FLIP	FLIP	NNP
cord-016523-pznw2ciu	342	16	CD95	CD95	NNP
cord-016523-pznw2ciu	342	17	promotes	promote	VBZ
cord-016523-pznw2ciu	342	18	tumour	tumour	NN
cord-016523-pznw2ciu	342	19	growth	growth	NN
cord-016523-pznw2ciu	343	1	Yes	yes	UH
cord-016523-pznw2ciu	343	2	and	and	CC
cord-016523-pznw2ciu	343	3	PI3	pi3	NN
cord-016523-pznw2ciu	343	4	K	K	NNP
cord-016523-pznw2ciu	343	5	bind	bind	VB
cord-016523-pznw2ciu	343	6	CD95	CD95	NNP
cord-016523-pznw2ciu	343	7	to	to	TO
cord-016523-pznw2ciu	343	8	signal	signal	VB
cord-016523-pznw2ciu	343	9	invasion	invasion	NN
cord-016523-pznw2ciu	343	10	of	of	IN
cord-016523-pznw2ciu	343	11	glioblastoma	glioblastoma	NN
cord-016523-pznw2ciu	343	12	Stromelysin-1	Stromelysin-1	NNP
cord-016523-pznw2ciu	344	1	(	(	-LRB-
cord-016523-pznw2ciu	344	2	MMP-3	MMP-3	NNP
cord-016523-pznw2ciu	344	3	)	)	-RRB-
cord-016523-pznw2ciu	344	4	in	in	IN
cord-016523-pznw2ciu	344	5	synovial	synovial	JJ
cord-016523-pznw2ciu	344	6	fl	fl	NNP
cord-016523-pznw2ciu	344	7	uid	uid	NN
cord-016523-pznw2ciu	344	8	of	of	IN
cord-016523-pznw2ciu	344	9	patients	patient	NNS
cord-016523-pznw2ciu	344	10	with	with	IN
cord-016523-pznw2ciu	344	11	rheumatoid	rheumatoid	NN
cord-016523-pznw2ciu	344	12	arthritis	arthritis	NN
cord-016523-pznw2ciu	344	13	has	have	VBZ
cord-016523-pznw2ciu	344	14	potential	potential	NN
cord-016523-pznw2ciu	344	15	to	to	TO
cord-016523-pznw2ciu	344	16	cleave	cleave	VB
cord-016523-pznw2ciu	344	17	membrane	membrane	NN
cord-016523-pznw2ciu	344	18	bound	bind	VBN
cord-016523-pznw2ciu	344	19	Fas	Fas	NNP
cord-016523-pznw2ciu	344	20	ligand	ligand	NN
cord-016523-pznw2ciu	344	21	Identifi	Identifi	NNP
cord-016523-pznw2ciu	344	22	cation	cation	NN
cord-016523-pznw2ciu	344	23	of	of	IN
cord-016523-pznw2ciu	344	24	novel	novel	NN
cord-016523-pznw2ciu	344	25	matrix	matrix	NN
cord-016523-pznw2ciu	344	26	metalloproteinase-7	metalloproteinase-7	NNP
cord-016523-pznw2ciu	345	1	(	(	-LRB-
cord-016523-pznw2ciu	345	2	matrilysin	matrilysin	NNP
cord-016523-pznw2ciu	345	3	)	)	-RRB-
cord-016523-pznw2ciu	345	4	cleavage	cleavage	NN
cord-016523-pznw2ciu	345	5	sites	site	NNS
cord-016523-pznw2ciu	345	6	in	in	IN
cord-016523-pznw2ciu	345	7	murine	murine	JJ
cord-016523-pznw2ciu	345	8	and	and	CC
cord-016523-pznw2ciu	345	9	human	human	JJ
cord-016523-pznw2ciu	345	10	Fas	Fas	NNP
cord-016523-pznw2ciu	345	11	ligand	ligand	NN
cord-016523-pznw2ciu	345	12	Matrix	Matrix	NNP
cord-016523-pznw2ciu	345	13	metalloproteinase-9	metalloproteinase-9	NNP
cord-016523-pznw2ciu	345	14	regulates	regulate	VBZ
cord-016523-pznw2ciu	345	15	TNF	TNF	NNP
cord-016523-pznw2ciu	345	16	-	-	HYPH
cord-016523-pznw2ciu	345	17	alpha	alpha	NN
cord-016523-pznw2ciu	345	18	and	and	CC
cord-016523-pznw2ciu	345	19	FasL	FasL	NNP
cord-016523-pznw2ciu	345	20	expression	expression	NN
cord-016523-pznw2ciu	345	21	in	in	IN
cord-016523-pznw2ciu	345	22	neuronal	neuronal	JJ
cord-016523-pznw2ciu	345	23	,	,	,
cord-016523-pznw2ciu	345	24	glial	glial	JJ
cord-016523-pznw2ciu	345	25	cells	cell	NNS
cord-016523-pznw2ciu	345	26	and	and	CC
cord-016523-pznw2ciu	345	27	its	-PRON-	PRP$
cord-016523-pznw2ciu	345	28	absence	absence	NN
cord-016523-pznw2ciu	345	29	extends	extend	VBZ
cord-016523-pznw2ciu	345	30	life	life	NN
cord-016523-pznw2ciu	345	31	in	in	IN
cord-016523-pznw2ciu	345	32	a	a	DT
cord-016523-pznw2ciu	345	33	transgenic	transgenic	JJ
cord-016523-pznw2ciu	345	34	mouse	mouse	NN
cord-016523-pznw2ciu	345	35	model	model	NN
cord-016523-pznw2ciu	345	36	of	of	IN
cord-016523-pznw2ciu	345	37	amyotrophic	amyotrophic	JJ
cord-016523-pznw2ciu	345	38	lateral	lateral	JJ
cord-016523-pznw2ciu	345	39	sclerosis	sclerosis	NN
cord-016523-pznw2ciu	346	1	The	the	DT
cord-016523-pznw2ciu	346	2	Fas	Fas	NNP
cord-016523-pznw2ciu	346	3	ligand	ligand	NN
cord-016523-pznw2ciu	346	4	intracellular	intracellular	JJ
cord-016523-pznw2ciu	346	5	domain	domain	NN
cord-016523-pznw2ciu	346	6	is	be	VBZ
cord-016523-pznw2ciu	346	7	released	release	VBN
cord-016523-pznw2ciu	346	8	by	by	IN
cord-016523-pznw2ciu	346	9	ADAM10	adam10	NN
cord-016523-pznw2ciu	346	10	and	and	CC
cord-016523-pznw2ciu	346	11	SPPL2a	sppl2a	JJ
cord-016523-pznw2ciu	346	12	cleavage	cleavage	NN
cord-016523-pznw2ciu	346	13	in	in	IN
cord-016523-pznw2ciu	346	14	T	t	NN
cord-016523-pznw2ciu	346	15	-	-	HYPH
cord-016523-pznw2ciu	346	16	cells	cell	NNS
cord-016523-pznw2ciu	347	1	ADAM10	ADAM10	NNP
cord-016523-pznw2ciu	347	2	regulates	regulate	VBZ
cord-016523-pznw2ciu	347	3	FasL	FasL	NNP
cord-016523-pznw2ciu	347	4	cell	cell	NN
cord-016523-pznw2ciu	347	5	surface	surface	NN
cord-016523-pznw2ciu	347	6	expression	expression	NN
cord-016523-pznw2ciu	347	7	and	and	CC
cord-016523-pznw2ciu	347	8	modulates	modulate	VBZ
cord-016523-pznw2ciu	347	9	FasL	FasL	NNP
cord-016523-pznw2ciu	347	10	-	-	HYPH
cord-016523-pznw2ciu	347	11	induced	induce	VBN
cord-016523-pznw2ciu	347	12	cytotoxicity	cytotoxicity	NN
cord-016523-pznw2ciu	347	13	and	and	CC
cord-016523-pznw2ciu	347	14	activation	activation	NN
cord-016523-pznw2ciu	347	15	-	-	HYPH
cord-016523-pznw2ciu	347	16	induced	induce	VBN
cord-016523-pznw2ciu	347	17	cell	cell	NN
cord-016523-pznw2ciu	347	18	death	death	NN
cord-016523-pznw2ciu	348	1	Two	two	CD
cord-016523-pznw2ciu	348	2	adjacent	adjacent	JJ
cord-016523-pznw2ciu	348	3	trimeric	trimeric	NNP
cord-016523-pznw2ciu	349	1	Fas	Fas	NNP
cord-016523-pznw2ciu	349	2	ligands	ligand	NNS
cord-016523-pznw2ciu	349	3	are	be	VBP
cord-016523-pznw2ciu	349	4	required	require	VBN
cord-016523-pznw2ciu	349	5	for	for	IN
cord-016523-pznw2ciu	349	6	Fas	Fas	NNP
cord-016523-pznw2ciu	349	7	signaling	signaling	NN
cord-016523-pznw2ciu	349	8	and	and	CC
cord-016523-pznw2ciu	349	9	formation	formation	NN
cord-016523-pznw2ciu	349	10	of	of	IN
cord-016523-pznw2ciu	349	11	a	a	DT
cord-016523-pznw2ciu	349	12	deathinducing	deathinduce	VBG
cord-016523-pznw2ciu	349	13	signaling	signal	VBG
cord-016523-pznw2ciu	349	14	complex	complex	JJ
cord-016523-pznw2ciu	349	15	Conversion	conversion	NN
cord-016523-pznw2ciu	349	16	of	of	IN
cord-016523-pznw2ciu	349	17	membrane	membrane	NN
cord-016523-pznw2ciu	349	18	-	-	HYPH
cord-016523-pznw2ciu	349	19	bound	bind	VBN
cord-016523-pznw2ciu	349	20	Fas(CD95	Fas(CD95	NNP
cord-016523-pznw2ciu	349	21	)	)	-RRB-
cord-016523-pznw2ciu	349	22	ligand	ligand	NN
cord-016523-pznw2ciu	349	23	to	to	IN
cord-016523-pznw2ciu	349	24	its	-PRON-	PRP$
cord-016523-pznw2ciu	349	25	soluble	soluble	JJ
cord-016523-pznw2ciu	349	26	form	form	NN
cord-016523-pznw2ciu	349	27	is	be	VBZ
cord-016523-pznw2ciu	349	28	associated	associate	VBN
cord-016523-pznw2ciu	349	29	with	with	IN
cord-016523-pznw2ciu	349	30	downregulation	downregulation	NN
cord-016523-pznw2ciu	349	31	of	of	IN
cord-016523-pznw2ciu	349	32	its	-PRON-	PRP$
cord-016523-pznw2ciu	349	33	proapoptotic	proapoptotic	JJ
cord-016523-pznw2ciu	349	34	activity	activity	NN
cord-016523-pznw2ciu	349	35	and	and	CC
cord-016523-pznw2ciu	349	36	loss	loss	NN
cord-016523-pznw2ciu	349	37	of	of	IN
cord-016523-pznw2ciu	349	38	liver	liver	NN
cord-016523-pznw2ciu	349	39	toxicity	toxicity	NN
cord-016523-pznw2ciu	349	40	Membrane	membrane	NN
cord-016523-pznw2ciu	349	41	Fas	Fas	NNP
cord-016523-pznw2ciu	349	42	ligand	ligand	NN
cord-016523-pznw2ciu	349	43	kills	kill	VBZ
cord-016523-pznw2ciu	349	44	human	human	JJ
cord-016523-pznw2ciu	349	45	peripheral	peripheral	JJ
cord-016523-pznw2ciu	349	46	blood	blood	NN
cord-016523-pznw2ciu	349	47	T	t	NN
cord-016523-pznw2ciu	349	48	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	349	49	,	,	,
cord-016523-pznw2ciu	349	50	and	and	CC
cord-016523-pznw2ciu	349	51	soluble	soluble	JJ
cord-016523-pznw2ciu	349	52	Fas	Fas	NNP
cord-016523-pznw2ciu	349	53	ligand	ligand	NN
cord-016523-pznw2ciu	349	54	blocks	block	VBZ
cord-016523-pznw2ciu	349	55	the	the	DT
cord-016523-pznw2ciu	349	56	killing	killing	NN
cord-016523-pznw2ciu	349	57	CD95L	cd95l	NN
cord-016523-pznw2ciu	349	58	cell	cell	NN
cord-016523-pznw2ciu	349	59	surface	surface	NN
cord-016523-pznw2ciu	349	60	cleavage	cleavage	NN
cord-016523-pznw2ciu	349	61	triggers	trigger	VBZ
cord-016523-pznw2ciu	349	62	a	a	DT
cord-016523-pznw2ciu	349	63	pro	pro	JJ
cord-016523-pznw2ciu	349	64	-	-	JJ
cord-016523-pznw2ciu	349	65	metastatic	metastatic	JJ
cord-016523-pznw2ciu	349	66	signaling	signal	VBG
cord-016523-pznw2ciu	349	67	pathway	pathway	NN
cord-016523-pznw2ciu	349	68	in	in	IN
cord-016523-pznw2ciu	349	69	triple	triple	JJ
cord-016523-pznw2ciu	349	70	negative	negative	JJ
cord-016523-pznw2ciu	349	71	breast	breast	NN
cord-016523-pznw2ciu	349	72	cancer	cancer	NN
cord-016523-pznw2ciu	349	73	Src	Src	NNP
cord-016523-pznw2ciu	349	74	kinase	kinase	NN
cord-016523-pznw2ciu	349	75	phosphorylates	phosphorylate	VBZ
cord-016523-pznw2ciu	349	76	Caspase-8	Caspase-8	NNP
cord-016523-pznw2ciu	349	77	on	on	IN
cord-016523-pznw2ciu	349	78	Tyr380	tyr380	CD
cord-016523-pznw2ciu	349	79	:	:	:
cord-016523-pznw2ciu	349	80	a	a	DT
cord-016523-pznw2ciu	349	81	novel	novel	JJ
cord-016523-pznw2ciu	349	82	mechanism	mechanism	NN
cord-016523-pznw2ciu	349	83	of	of	IN
cord-016523-pznw2ciu	349	84	apoptosis	apoptosis	NN
cord-016523-pznw2ciu	349	85	suppression	suppression	NN
cord-016523-pznw2ciu	349	86	Caspase-8	Caspase-8	NNP
cord-016523-pznw2ciu	349	87	interacts	interact	VBZ
cord-016523-pznw2ciu	349	88	with	with	IN
cord-016523-pznw2ciu	349	89	the	the	DT
cord-016523-pznw2ciu	349	90	p85	p85	NN
cord-016523-pznw2ciu	349	91	subunit	subunit	NN
cord-016523-pznw2ciu	349	92	of	of	IN
cord-016523-pznw2ciu	349	93	phosphatidylinositol	phosphatidylinositol	JJ
cord-016523-pznw2ciu	349	94	3-kinase	3-kinase	CD
cord-016523-pznw2ciu	349	95	to	to	TO
cord-016523-pznw2ciu	349	96	regulate	regulate	VB
cord-016523-pznw2ciu	349	97	cell	cell	NN
cord-016523-pznw2ciu	349	98	adhesion	adhesion	NN
cord-016523-pznw2ciu	349	99	and	and	CC
cord-016523-pznw2ciu	349	100	motility	motility	NN
cord-016523-pznw2ciu	349	101	How	how	WRB
cord-016523-pznw2ciu	349	102	CD95	CD95	NNP
cord-016523-pznw2ciu	349	103	stimulates	stimulate	VBZ
cord-016523-pznw2ciu	349	104	invasion	invasion	NN
cord-016523-pznw2ciu	349	105	FAS	FAS	NNP
cord-016523-pznw2ciu	349	106	and	and	CC
cord-016523-pznw2ciu	349	107	NF	NF	NNP
cord-016523-pznw2ciu	349	108	-	-	HYPH
cord-016523-pznw2ciu	349	109	kappaB	kappaB	NNP
cord-016523-pznw2ciu	349	110	signalling	signalling	NN
cord-016523-pznw2ciu	349	111	modulate	modulate	VBP
cord-016523-pznw2ciu	349	112	dependence	dependence	NN
cord-016523-pznw2ciu	349	113	of	of	IN
cord-016523-pznw2ciu	349	114	lung	lung	NN
cord-016523-pznw2ciu	349	115	cancers	cancer	NNS
cord-016523-pznw2ciu	349	116	on	on	IN
cord-016523-pznw2ciu	349	117	mutant	mutant	JJ
cord-016523-pznw2ciu	349	118	EGFR	EGFR	NNP
cord-016523-pznw2ciu	349	119	Production	Production	NNP
cord-016523-pznw2ciu	349	120	and	and	CC
cord-016523-pznw2ciu	349	121	pro	pro	JJ
cord-016523-pznw2ciu	349	122	-	-	JJ
cord-016523-pznw2ciu	349	123	apoptotic	apoptotic	JJ
cord-016523-pznw2ciu	349	124	activity	activity	NN
cord-016523-pznw2ciu	349	125	of	of	IN
cord-016523-pznw2ciu	349	126	soluble	soluble	JJ
cord-016523-pznw2ciu	349	127	CD95	CD95	NNP
cord-016523-pznw2ciu	349	128	ligand	ligand	NN
cord-016523-pznw2ciu	349	129	in	in	IN
cord-016523-pznw2ciu	349	130	pancreatic	pancreatic	JJ
cord-016523-pznw2ciu	349	131	carcinoma	carcinoma	NN
cord-016523-pznw2ciu	349	132	Fas	Fas	NNP
cord-016523-pznw2ciu	349	133	ligand	ligand	NN
cord-016523-pznw2ciu	349	134	in	in	IN
cord-016523-pznw2ciu	349	135	human	human	JJ
cord-016523-pznw2ciu	349	136	serum	serum	NN
cord-016523-pznw2ciu	349	137	Soluble	Soluble	NNP
cord-016523-pznw2ciu	349	138	Fas	Fas	NNP
cord-016523-pznw2ciu	349	139	ligand	ligand	NN
cord-016523-pznw2ciu	349	140	in	in	IN
cord-016523-pznw2ciu	349	141	the	the	DT
cord-016523-pznw2ciu	349	142	joints	joint	NNS
cord-016523-pznw2ciu	349	143	of	of	IN
cord-016523-pznw2ciu	349	144	patients	patient	NNS
cord-016523-pznw2ciu	349	145	with	with	IN
cord-016523-pznw2ciu	349	146	rheumatoid	rheumatoid	NN
cord-016523-pznw2ciu	349	147	arthritis	arthritis	NN
cord-016523-pznw2ciu	349	148	and	and	CC
cord-016523-pznw2ciu	349	149	osteoarthritis	osteoarthritis	NN
cord-016523-pznw2ciu	349	150	Levels	level	NNS
cord-016523-pznw2ciu	349	151	of	of	IN
cord-016523-pznw2ciu	349	152	soluble	soluble	JJ
cord-016523-pznw2ciu	349	153	FasL	FasL	NNP
cord-016523-pznw2ciu	349	154	and	and	CC
cord-016523-pznw2ciu	349	155	FasL	FasL	NNP
cord-016523-pznw2ciu	349	156	gene	gene	NN
cord-016523-pznw2ciu	349	157	expression	expression	NN
cord-016523-pznw2ciu	349	158	during	during	IN
cord-016523-pznw2ciu	349	159	the	the	DT
cord-016523-pznw2ciu	349	160	development	development	NN
cord-016523-pznw2ciu	349	161	of	of	IN
cord-016523-pznw2ciu	349	162	graft	graft	NN
cord-016523-pznw2ciu	349	163	-	-	HYPH
cord-016523-pznw2ciu	349	164	versushost	versushost	NN
cord-016523-pznw2ciu	349	165	disease	disease	NN
cord-016523-pznw2ciu	349	166	in	in	IN
cord-016523-pznw2ciu	349	167	DLT	DLT	NNP
cord-016523-pznw2ciu	349	168	-	-	HYPH
cord-016523-pznw2ciu	349	169	treated	treat	VBN
cord-016523-pznw2ciu	349	170	patients	patient	NNS
cord-016523-pznw2ciu	350	1	Increased	increase	VBN
cord-016523-pznw2ciu	350	2	soluble	soluble	JJ
cord-016523-pznw2ciu	350	3	Fas	Fas	NNP
cord-016523-pznw2ciu	350	4	-	-	HYPH
cord-016523-pznw2ciu	350	5	ligand	ligand	NNP
cord-016523-pznw2ciu	350	6	in	in	IN
cord-016523-pznw2ciu	350	7	sera	sera	NNP
cord-016523-pznw2ciu	350	8	of	of	IN
cord-016523-pznw2ciu	350	9	bone	bone	NN
cord-016523-pznw2ciu	350	10	marrow	marrow	NN
cord-016523-pznw2ciu	350	11	transplant	transplant	NN
cord-016523-pznw2ciu	350	12	recipients	recipient	NNS
cord-016523-pznw2ciu	350	13	with	with	IN
cord-016523-pznw2ciu	350	14	acute	acute	JJ
cord-016523-pznw2ciu	350	15	graft	graft	NN
cord-016523-pznw2ciu	350	16	-	-	HYPH
cord-016523-pznw2ciu	350	17	versus	versus	IN
cord-016523-pznw2ciu	350	18	-	-	HYPH
cord-016523-pznw2ciu	350	19	host	host	NN
cord-016523-pznw2ciu	350	20	disease	disease	NN
cord-016523-pznw2ciu	350	21	Serum	serum	NN
cord-016523-pznw2ciu	350	22	levels	level	NNS
cord-016523-pznw2ciu	350	23	of	of	IN
cord-016523-pznw2ciu	350	24	soluble	soluble	JJ
cord-016523-pznw2ciu	350	25	Fas	Fas	NNP
cord-016523-pznw2ciu	350	26	ligand	ligand	NN
cord-016523-pznw2ciu	350	27	in	in	IN
cord-016523-pznw2ciu	350	28	patients	patient	NNS
cord-016523-pznw2ciu	350	29	with	with	IN
cord-016523-pznw2ciu	350	30	silicosis	silicosis	NN
cord-016523-pznw2ciu	351	1	The	the	DT
cord-016523-pznw2ciu	351	2	biological	biological	JJ
cord-016523-pznw2ciu	351	3	activity	activity	NN
cord-016523-pznw2ciu	351	4	of	of	IN
cord-016523-pznw2ciu	351	5	FasL	FasL	NNP
cord-016523-pznw2ciu	351	6	in	in	IN
cord-016523-pznw2ciu	351	7	human	human	NN
cord-016523-pznw2ciu	351	8	and	and	CC
cord-016523-pznw2ciu	351	9	mouse	mouse	NN
cord-016523-pznw2ciu	351	10	lungs	lung	NNS
cord-016523-pznw2ciu	351	11	is	be	VBZ
cord-016523-pznw2ciu	351	12	determined	determine	VBN
cord-016523-pznw2ciu	351	13	by	by	IN
cord-016523-pznw2ciu	351	14	the	the	DT
cord-016523-pznw2ciu	351	15	structure	structure	NN
cord-016523-pznw2ciu	351	16	of	of	IN
cord-016523-pznw2ciu	351	17	its	-PRON-	PRP$
cord-016523-pznw2ciu	351	18	stalk	stalk	NN
cord-016523-pznw2ciu	351	19	region	region	NN
cord-016523-pznw2ciu	351	20	Diacylglycerol	Diacylglycerol	NNP
cord-016523-pznw2ciu	351	21	kinase	kinase	NN
cord-016523-pznw2ciu	351	22	alpha	alpha	NN
cord-016523-pznw2ciu	351	23	regulates	regulate	VBZ
cord-016523-pznw2ciu	351	24	the	the	DT
cord-016523-pznw2ciu	351	25	formation	formation	NN
cord-016523-pznw2ciu	351	26	and	and	CC
cord-016523-pznw2ciu	351	27	polarisation	polarisation	NN
cord-016523-pznw2ciu	351	28	of	of	IN
cord-016523-pznw2ciu	351	29	mature	mature	JJ
cord-016523-pznw2ciu	351	30	multivesicular	multivesicular	JJ
cord-016523-pznw2ciu	351	31	bodies	body	NNS
cord-016523-pznw2ciu	351	32	involved	involve	VBN
cord-016523-pznw2ciu	351	33	in	in	IN
cord-016523-pznw2ciu	351	34	the	the	DT
cord-016523-pznw2ciu	351	35	secretion	secretion	NN
cord-016523-pznw2ciu	351	36	of	of	IN
cord-016523-pznw2ciu	351	37	Fas	Fas	NNP
cord-016523-pznw2ciu	351	38	ligand	ligand	NN
cord-016523-pznw2ciu	351	39	-	-	HYPH
cord-016523-pznw2ciu	351	40	containing	contain	VBG
cord-016523-pznw2ciu	351	41	exosomes	exosome	NNS
cord-016523-pznw2ciu	351	42	in	in	IN
cord-016523-pznw2ciu	351	43	T	T	NNP
cord-016523-pznw2ciu	351	44	lymphocytes	lymphocyte	NNS
cord-016523-pznw2ciu	351	45	Modulation	modulation	NN
cord-016523-pznw2ciu	351	46	of	of	IN
cord-016523-pznw2ciu	351	47	the	the	DT
cord-016523-pznw2ciu	351	48	immune	immune	JJ
cord-016523-pznw2ciu	351	49	response	response	NN
cord-016523-pznw2ciu	351	50	using	use	VBG
cord-016523-pznw2ciu	351	51	dendritic	dendritic	JJ
cord-016523-pznw2ciu	351	52	cell	cell	NN
cord-016523-pznw2ciu	351	53	-	-	HYPH
cord-016523-pznw2ciu	351	54	derived	derive	VBN
cord-016523-pznw2ciu	351	55	exosomes	exosomes	NNP
cord-016523-pznw2ciu	351	56	Tumor	tumor	NN
cord-016523-pznw2ciu	351	57	exosomes	exosome	NNS
cord-016523-pznw2ciu	351	58	expressing	express	VBG
cord-016523-pznw2ciu	351	59	Fas	Fas	NNP
cord-016523-pznw2ciu	351	60	ligand	ligand	NN
cord-016523-pznw2ciu	351	61	mediate	mediate	VBP
cord-016523-pznw2ciu	351	62	CD8	CD8	NNP
cord-016523-pznw2ciu	351	63	+	+	CC
cord-016523-pznw2ciu	351	64	T	t	NN
cord-016523-pznw2ciu	351	65	-	-	HYPH
cord-016523-pznw2ciu	351	66	cell	cell	NN
cord-016523-pznw2ciu	351	67	apoptosis	apoptosis	NN