id	sid	tid	token	lemma	pos
cord-017640-i8h48ny6	1	1	key	key	NN
cord-017640-i8h48ny6	1	2	:	:	:
cord-017640-i8h48ny6	1	3	cord-017640-i8h48ny6	cord-017640-i8h48ny6	NNP
cord-017640-i8h48ny6	1	4	authors	author	NNS
cord-017640-i8h48ny6	1	5	:	:	:
cord-017640-i8h48ny6	1	6	Fouqué	Fouqué	NNP
cord-017640-i8h48ny6	1	7	,	,	,
cord-017640-i8h48ny6	1	8	Amélie	Amélie	NNP
cord-017640-i8h48ny6	1	9	;	;	:
cord-017640-i8h48ny6	1	10	Legembre	Legembre	NNP
cord-017640-i8h48ny6	1	11	,	,	,
cord-017640-i8h48ny6	1	12	Patrick	Patrick	NNP
cord-017640-i8h48ny6	2	1	title	title	NN
cord-017640-i8h48ny6	2	2	:	:	:
cord-017640-i8h48ny6	2	3	The	the	DT
cord-017640-i8h48ny6	2	4	CD95	CD95	NNP
cord-017640-i8h48ny6	2	5	/	/	SYM
cord-017640-i8h48ny6	2	6	CD95L	cd95l	NN
cord-017640-i8h48ny6	3	1	Signaling	Signaling	NNP
cord-017640-i8h48ny6	3	2	Pathway	Pathway	NNP
cord-017640-i8h48ny6	3	3	:	:	:
cord-017640-i8h48ny6	4	1	A	a	DT
cord-017640-i8h48ny6	4	2	Role	role	NN
cord-017640-i8h48ny6	4	3	in	in	IN
cord-017640-i8h48ny6	4	4	Carcinogenesis	carcinogenesis	NN
cord-017640-i8h48ny6	4	5	date	date	NN
cord-017640-i8h48ny6	4	6	:	:	:
cord-017640-i8h48ny6	4	7	2020	2020	CD
cord-017640-i8h48ny6	4	8	-	-	HYPH
cord-017640-i8h48ny6	4	9	01	01	CD
cord-017640-i8h48ny6	4	10	-	-	HYPH
cord-017640-i8h48ny6	4	11	03	03	CD
cord-017640-i8h48ny6	4	12	journal	journal	NN
cord-017640-i8h48ny6	4	13	:	:	:
cord-017640-i8h48ny6	5	1	Cancer	Cancer	NNP
cord-017640-i8h48ny6	5	2	Immunology	Immunology	NNP
cord-017640-i8h48ny6	5	3	DOI	doi	NN
cord-017640-i8h48ny6	5	4	:	:	:
cord-017640-i8h48ny6	5	5	10.1007/978	10.1007/978	CD
cord-017640-i8h48ny6	5	6	-	-	HYPH
cord-017640-i8h48ny6	5	7	3	3	CD
cord-017640-i8h48ny6	5	8	-	-	HYPH
cord-017640-i8h48ny6	5	9	030	030	CD
cord-017640-i8h48ny6	5	10	-	-	HYPH
cord-017640-i8h48ny6	5	11	30845	30845	CD
cord-017640-i8h48ny6	5	12	-	-	HYPH
cord-017640-i8h48ny6	5	13	2_11	2_11	CD
cord-017640-i8h48ny6	5	14	sha	sha	NNP
cord-017640-i8h48ny6	5	15	:	:	:
cord-017640-i8h48ny6	6	1	19df05ebe2ea59b92285463121a95271806b56ab	19df05ebe2ea59b92285463121a95271806b56ab	NNP
cord-017640-i8h48ny6	6	2	doc_id	doc_id	CD
cord-017640-i8h48ny6	6	3	:	:	:
cord-017640-i8h48ny6	6	4	17640	17640	CD
cord-017640-i8h48ny6	6	5	cord_uid	cord_uid	NNS
cord-017640-i8h48ny6	6	6	:	:	:
cord-017640-i8h48ny6	7	1	i8h48ny6	i8h48ny6	NFP
cord-017640-i8h48ny6	7	2	Apoptosis	apoptosis	NN
cord-017640-i8h48ny6	7	3	is	be	VBZ
cord-017640-i8h48ny6	7	4	a	a	DT
cord-017640-i8h48ny6	7	5	fundamental	fundamental	JJ
cord-017640-i8h48ny6	7	6	process	process	NN
cord-017640-i8h48ny6	7	7	contributing	contribute	VBG
cord-017640-i8h48ny6	7	8	to	to	IN
cord-017640-i8h48ny6	7	9	tissue	tissue	NN
cord-017640-i8h48ny6	7	10	homeostasis	homeostasis	NN
cord-017640-i8h48ny6	7	11	,	,	,
cord-017640-i8h48ny6	7	12	immune	immune	JJ
cord-017640-i8h48ny6	7	13	response	response	NN
cord-017640-i8h48ny6	7	14	,	,	,
cord-017640-i8h48ny6	7	15	and	and	CC
cord-017640-i8h48ny6	7	16	development	development	NN
cord-017640-i8h48ny6	7	17	.	.	.
cord-017640-i8h48ny6	8	1	CD95	CD95	NNP
cord-017640-i8h48ny6	8	2	,	,	,
cord-017640-i8h48ny6	8	3	also	also	RB
cord-017640-i8h48ny6	8	4	called	call	VBN
cord-017640-i8h48ny6	8	5	Fas	Fas	NNP
cord-017640-i8h48ny6	8	6	,	,	,
cord-017640-i8h48ny6	8	7	is	be	VBZ
cord-017640-i8h48ny6	8	8	a	a	DT
cord-017640-i8h48ny6	8	9	member	member	NN
cord-017640-i8h48ny6	8	10	of	of	IN
cord-017640-i8h48ny6	8	11	the	the	DT
cord-017640-i8h48ny6	8	12	tumor	tumor	NN
cord-017640-i8h48ny6	8	13	necrosis	necrosis	NN
cord-017640-i8h48ny6	8	14	factor	factor	NN
cord-017640-i8h48ny6	8	15	receptor	receptor	NN
cord-017640-i8h48ny6	8	16	(	(	-LRB-
cord-017640-i8h48ny6	8	17	TNFR	TNFR	NNP
cord-017640-i8h48ny6	8	18	)	)	-RRB-
cord-017640-i8h48ny6	8	19	superfamily	superfamily	NN
cord-017640-i8h48ny6	8	20	.	.	.
cord-017640-i8h48ny6	9	1	Its	-PRON-	PRP$
cord-017640-i8h48ny6	9	2	ligand	ligand	NN
cord-017640-i8h48ny6	9	3	,	,	,
cord-017640-i8h48ny6	9	4	CD95L	cd95l	NN
cord-017640-i8h48ny6	9	5	,	,	,
cord-017640-i8h48ny6	9	6	was	be	VBD
cord-017640-i8h48ny6	9	7	initially	initially	RB
cord-017640-i8h48ny6	9	8	detected	detect	VBN
cord-017640-i8h48ny6	9	9	at	at	IN
cord-017640-i8h48ny6	9	10	the	the	DT
cord-017640-i8h48ny6	9	11	plasma	plasma	NN
cord-017640-i8h48ny6	9	12	membrane	membrane	NN
cord-017640-i8h48ny6	9	13	of	of	IN
cord-017640-i8h48ny6	9	14	activated	activate	VBN
cord-017640-i8h48ny6	9	15	T	t	NN
cord-017640-i8h48ny6	9	16	-	-	HYPH
cord-017640-i8h48ny6	9	17	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	9	18	and	and	CC
cord-017640-i8h48ny6	9	19	natural	natural	JJ
cord-017640-i8h48ny6	9	20	killer	killer	NN
cord-017640-i8h48ny6	9	21	(	(	-LRB-
cord-017640-i8h48ny6	9	22	NK	NK	NNP
cord-017640-i8h48ny6	9	23	)	)	-RRB-
cord-017640-i8h48ny6	9	24	cells	cell	NNS
cord-017640-i8h48ny6	9	25	where	where	WRB
cord-017640-i8h48ny6	9	26	it	-PRON-	PRP
cord-017640-i8h48ny6	9	27	contributes	contribute	VBZ
cord-017640-i8h48ny6	9	28	to	to	IN
cord-017640-i8h48ny6	9	29	the	the	DT
cord-017640-i8h48ny6	9	30	elimination	elimination	NN
cord-017640-i8h48ny6	9	31	of	of	IN
cord-017640-i8h48ny6	9	32	transformed	transform	VBN
cord-017640-i8h48ny6	9	33	and	and	CC
cord-017640-i8h48ny6	9	34	infected	infected	JJ
cord-017640-i8h48ny6	9	35	cells	cell	NNS
cord-017640-i8h48ny6	9	36	.	.	.
cord-017640-i8h48ny6	10	1	Given	give	VBN
cord-017640-i8h48ny6	10	2	its	-PRON-	PRP$
cord-017640-i8h48ny6	10	3	implication	implication	NN
cord-017640-i8h48ny6	10	4	in	in	IN
cord-017640-i8h48ny6	10	5	immune	immune	JJ
cord-017640-i8h48ny6	10	6	homeostasis	homeostasis	NN
cord-017640-i8h48ny6	10	7	and	and	CC
cord-017640-i8h48ny6	10	8	immune	immune	JJ
cord-017640-i8h48ny6	10	9	surveillance	surveillance	NN
cord-017640-i8h48ny6	10	10	combined	combine	VBN
cord-017640-i8h48ny6	10	11	with	with	IN
cord-017640-i8h48ny6	10	12	the	the	DT
cord-017640-i8h48ny6	10	13	fact	fact	NN
cord-017640-i8h48ny6	10	14	that	that	IN
cord-017640-i8h48ny6	10	15	various	various	JJ
cord-017640-i8h48ny6	10	16	lineages	lineage	NNS
cord-017640-i8h48ny6	10	17	of	of	IN
cord-017640-i8h48ny6	10	18	malignant	malignant	JJ
cord-017640-i8h48ny6	10	19	cells	cell	NNS
cord-017640-i8h48ny6	10	20	exhibit	exhibit	VBP
cord-017640-i8h48ny6	10	21	loss	loss	NN
cord-017640-i8h48ny6	10	22	-	-	HYPH
cord-017640-i8h48ny6	10	23	of	of	IN
cord-017640-i8h48ny6	10	24	-	-	HYPH
cord-017640-i8h48ny6	10	25	function	function	NN
cord-017640-i8h48ny6	10	26	mutations	mutation	NNS
cord-017640-i8h48ny6	10	27	,	,	,
cord-017640-i8h48ny6	10	28	CD95	CD95	NNP
cord-017640-i8h48ny6	10	29	was	be	VBD
cord-017640-i8h48ny6	10	30	initially	initially	RB
cord-017640-i8h48ny6	10	31	classified	classify	VBN
cord-017640-i8h48ny6	10	32	as	as	IN
cord-017640-i8h48ny6	10	33	a	a	DT
cord-017640-i8h48ny6	10	34	tumor	tumor	NN
cord-017640-i8h48ny6	10	35	suppressor	suppressor	NN
cord-017640-i8h48ny6	10	36	gene	gene	NN
cord-017640-i8h48ny6	10	37	.	.	.
cord-017640-i8h48ny6	11	1	Nonetheless	nonetheless	RB
cord-017640-i8h48ny6	11	2	,	,	,
cord-017640-i8h48ny6	11	3	in	in	IN
cord-017640-i8h48ny6	11	4	different	different	JJ
cord-017640-i8h48ny6	11	5	pathophysiological	pathophysiological	JJ
cord-017640-i8h48ny6	11	6	contexts	context	NNS
cord-017640-i8h48ny6	11	7	,	,	,
cord-017640-i8h48ny6	11	8	this	this	DT
cord-017640-i8h48ny6	11	9	receptor	receptor	NN
cord-017640-i8h48ny6	11	10	is	be	VBZ
cord-017640-i8h48ny6	11	11	able	able	JJ
cord-017640-i8h48ny6	11	12	to	to	TO
cord-017640-i8h48ny6	11	13	transmit	transmit	VB
cord-017640-i8h48ny6	11	14	non	non	JJ
cord-017640-i8h48ny6	11	15	-	-	JJ
cord-017640-i8h48ny6	11	16	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	11	17	signals	signal	NNS
cord-017640-i8h48ny6	11	18	and	and	CC
cord-017640-i8h48ny6	11	19	promote	promote	VB
cord-017640-i8h48ny6	11	20	inflammation	inflammation	NN
cord-017640-i8h48ny6	11	21	and	and	CC
cord-017640-i8h48ny6	11	22	carcinogenesis	carcinogenesis	NN
cord-017640-i8h48ny6	11	23	.	.	.
cord-017640-i8h48ny6	12	1	Although	although	IN
cord-017640-i8h48ny6	12	2	the	the	DT
cord-017640-i8h48ny6	12	3	different	different	JJ
cord-017640-i8h48ny6	12	4	non	non	JJ
cord-017640-i8h48ny6	12	5	-	-	JJ
cord-017640-i8h48ny6	12	6	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	12	7	signaling	signal	VBG
cord-017640-i8h48ny6	12	8	pathways	pathway	NNS
cord-017640-i8h48ny6	12	9	(	(	-LRB-
cord-017640-i8h48ny6	12	10	NF	nf	NN
cord-017640-i8h48ny6	12	11	-	-	HYPH
cord-017640-i8h48ny6	12	12	κB	κB	NNP
cord-017640-i8h48ny6	12	13	,	,	,
cord-017640-i8h48ny6	12	14	MAPK	MAPK	NNP
cord-017640-i8h48ny6	12	15	,	,	,
cord-017640-i8h48ny6	12	16	and	and	CC
cord-017640-i8h48ny6	12	17	PI3	PI3	NNP
cord-017640-i8h48ny6	12	18	K	K	NNP
cord-017640-i8h48ny6	12	19	)	)	-RRB-
cord-017640-i8h48ny6	12	20	triggered	trigger	VBN
cord-017640-i8h48ny6	12	21	by	by	IN
cord-017640-i8h48ny6	12	22	CD95	CD95	NNP
cord-017640-i8h48ny6	12	23	are	be	VBP
cord-017640-i8h48ny6	12	24	known	know	VBN
cord-017640-i8h48ny6	12	25	,	,	,
cord-017640-i8h48ny6	12	26	the	the	DT
cord-017640-i8h48ny6	12	27	initial	initial	JJ
cord-017640-i8h48ny6	12	28	molecular	molecular	JJ
cord-017640-i8h48ny6	12	29	events	event	NNS
cord-017640-i8h48ny6	12	30	leading	lead	VBG
cord-017640-i8h48ny6	12	31	to	to	IN
cord-017640-i8h48ny6	12	32	these	these	DT
cord-017640-i8h48ny6	12	33	signals	signal	NNS
cord-017640-i8h48ny6	12	34	,	,	,
cord-017640-i8h48ny6	12	35	the	the	DT
cord-017640-i8h48ny6	12	36	mechanisms	mechanism	NNS
cord-017640-i8h48ny6	12	37	by	by	IN
cord-017640-i8h48ny6	12	38	which	which	WDT
cord-017640-i8h48ny6	12	39	the	the	DT
cord-017640-i8h48ny6	12	40	receptor	receptor	NN
cord-017640-i8h48ny6	12	41	switches	switch	VBZ
cord-017640-i8h48ny6	12	42	from	from	IN
cord-017640-i8h48ny6	12	43	an	an	DT
cord-017640-i8h48ny6	12	44	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	12	45	function	function	NN
cord-017640-i8h48ny6	12	46	to	to	IN
cord-017640-i8h48ny6	12	47	an	an	DT
cord-017640-i8h48ny6	12	48	inflammatory	inflammatory	JJ
cord-017640-i8h48ny6	12	49	role	role	NN
cord-017640-i8h48ny6	12	50	,	,	,
cord-017640-i8h48ny6	12	51	and	and	CC
cord-017640-i8h48ny6	12	52	,	,	,
cord-017640-i8h48ny6	12	53	more	more	RBR
cord-017640-i8h48ny6	12	54	importantly	importantly	RB
cord-017640-i8h48ny6	12	55	,	,	,
cord-017640-i8h48ny6	12	56	the	the	DT
cord-017640-i8h48ny6	12	57	biological	biological	JJ
cord-017640-i8h48ny6	12	58	functions	function	NNS
cord-017640-i8h48ny6	12	59	of	of	IN
cord-017640-i8h48ny6	12	60	these	these	DT
cord-017640-i8h48ny6	12	61	signals	signal	NNS
cord-017640-i8h48ny6	12	62	remain	remain	VBP
cord-017640-i8h48ny6	12	63	elusive	elusive	JJ
cord-017640-i8h48ny6	12	64	.	.	.
cord-017640-i8h48ny6	13	1	Inhibition	inhibition	NN
cord-017640-i8h48ny6	13	2	of	of	IN
cord-017640-i8h48ny6	13	3	this	this	DT
cord-017640-i8h48ny6	13	4	cellular	cellular	JJ
cord-017640-i8h48ny6	13	5	process	process	NN
cord-017640-i8h48ny6	13	6	is	be	VBZ
cord-017640-i8h48ny6	13	7	observed	observe	VBN
cord-017640-i8h48ny6	13	8	in	in	IN
cord-017640-i8h48ny6	13	9	different	different	JJ
cord-017640-i8h48ny6	13	10	pathologies	pathology	NNS
cord-017640-i8h48ny6	13	11	,	,	,
cord-017640-i8h48ny6	13	12	such	such	JJ
cord-017640-i8h48ny6	13	13	as	as	IN
cord-017640-i8h48ny6	13	14	cancer	cancer	NN
cord-017640-i8h48ny6	13	15	and	and	CC
cord-017640-i8h48ny6	13	16	autoimmunity	autoimmunity	NN
cord-017640-i8h48ny6	13	17	,	,	,
cord-017640-i8h48ny6	13	18	while	while	IN
cord-017640-i8h48ny6	13	19	amplification	amplification	NN
cord-017640-i8h48ny6	13	20	of	of	IN
cord-017640-i8h48ny6	13	21	the	the	DT
cord-017640-i8h48ny6	13	22	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	13	23	signal	signal	NN
cord-017640-i8h48ny6	13	24	was	be	VBD
cord-017640-i8h48ny6	13	25	reported	report	VBN
cord-017640-i8h48ny6	13	26	in	in	IN
cord-017640-i8h48ny6	13	27	neurodegenerative	neurodegenerative	JJ
cord-017640-i8h48ny6	13	28	disorders	disorder	NNS
cord-017640-i8h48ny6	13	29	including	include	VBG
cord-017640-i8h48ny6	13	30	Alzheimer	Alzheimer	NNP
cord-017640-i8h48ny6	13	31	's	's	POS
cord-017640-i8h48ny6	13	32	and	and	CC
cord-017640-i8h48ny6	13	33	Parkinson	Parkinson	NNP
cord-017640-i8h48ny6	13	34	's	's	POS
cord-017640-i8h48ny6	13	35	diseases	disease	NNS
cord-017640-i8h48ny6	13	36	[	[	-LRB-
cord-017640-i8h48ny6	13	37	3	3	CD
cord-017640-i8h48ny6	13	38	,	,	,
cord-017640-i8h48ny6	13	39	4	4	CD
cord-017640-i8h48ny6	13	40	]	]	-RRB-
cord-017640-i8h48ny6	13	41	,	,	,
cord-017640-i8h48ny6	13	42	as	as	RB
cord-017640-i8h48ny6	13	43	well	well	RB
cord-017640-i8h48ny6	13	44	as	as	IN
cord-017640-i8h48ny6	13	45	infection	infection	NN
cord-017640-i8h48ny6	13	46	by	by	IN
cord-017640-i8h48ny6	13	47	human	human	JJ
cord-017640-i8h48ny6	13	48	immunodeficiency	immunodeficiency	NN
cord-017640-i8h48ny6	13	49	virus	virus	NN
cord-017640-i8h48ny6	13	50	(	(	-LRB-
cord-017640-i8h48ny6	13	51	HIV	HIV	NNP
cord-017640-i8h48ny6	13	52	)	)	-RRB-
cord-017640-i8h48ny6	13	53	.	.	.
cord-017640-i8h48ny6	14	1	The	the	DT
cord-017640-i8h48ny6	14	2	origin	origin	NN
cord-017640-i8h48ny6	14	3	of	of	IN
cord-017640-i8h48ny6	14	4	the	the	DT
cord-017640-i8h48ny6	14	5	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	14	6	signal	signal	NN
cord-017640-i8h48ny6	14	7	has	have	VBZ
cord-017640-i8h48ny6	14	8	been	be	VBN
cord-017640-i8h48ny6	14	9	used	use	VBN
cord-017640-i8h48ny6	14	10	to	to	TO
cord-017640-i8h48ny6	14	11	distinguish	distinguish	VB
cord-017640-i8h48ny6	14	12	two	two	CD
cord-017640-i8h48ny6	14	13	main	main	JJ
cord-017640-i8h48ny6	14	14	signaling	signal	VBG
cord-017640-i8h48ny6	14	15	pathways	pathway	NNS
cord-017640-i8h48ny6	14	16	.	.	.
cord-017640-i8h48ny6	15	1	The	the	DT
cord-017640-i8h48ny6	15	2	intrinsic	intrinsic	JJ
cord-017640-i8h48ny6	15	3	pathway	pathway	NN
cord-017640-i8h48ny6	15	4	stems	stem	VBZ
cord-017640-i8h48ny6	15	5	from	from	IN
cord-017640-i8h48ny6	15	6	accumulation	accumulation	NN
cord-017640-i8h48ny6	15	7	of	of	IN
cord-017640-i8h48ny6	15	8	DNA	dna	NN
cord-017640-i8h48ny6	15	9	damage	damage	NN
cord-017640-i8h48ny6	15	10	,	,	,
cord-017640-i8h48ny6	15	11	deregulation	deregulation	NN
cord-017640-i8h48ny6	15	12	of	of	IN
cord-017640-i8h48ny6	15	13	mitochondrial	mitochondrial	JJ
cord-017640-i8h48ny6	15	14	function	function	NN
cord-017640-i8h48ny6	15	15	,	,	,
cord-017640-i8h48ny6	15	16	or	or	CC
cord-017640-i8h48ny6	15	17	virus	virus	NN
cord-017640-i8h48ny6	15	18	infection	infection	NN
cord-017640-i8h48ny6	15	19	and	and	CC
cord-017640-i8h48ny6	15	20	induces	induce	VBZ
cord-017640-i8h48ny6	15	21	the	the	DT
cord-017640-i8h48ny6	15	22	release	release	NN
cord-017640-i8h48ny6	15	23	of	of	IN
cord-017640-i8h48ny6	15	24	proapoptotic	proapoptotic	JJ
cord-017640-i8h48ny6	15	25	factors	factor	NNS
cord-017640-i8h48ny6	15	26	from	from	IN
cord-017640-i8h48ny6	15	27	the	the	DT
cord-017640-i8h48ny6	15	28	mitochondria	mitochondrion	NNS
cord-017640-i8h48ny6	15	29	,	,	,
cord-017640-i8h48ny6	15	30	whereas	whereas	IN
cord-017640-i8h48ny6	15	31	extrinsic	extrinsic	JJ
cord-017640-i8h48ny6	15	32	signals	signal	NNS
cord-017640-i8h48ny6	15	33	are	be	VBP
cord-017640-i8h48ny6	15	34	transmitted	transmit	VBN
cord-017640-i8h48ny6	15	35	by	by	IN
cord-017640-i8h48ny6	15	36	the	the	DT
cord-017640-i8h48ny6	15	37	binding	binding	NN
cord-017640-i8h48ny6	15	38	of	of	IN
cord-017640-i8h48ny6	15	39	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	15	40	ligands	ligand	NNS
cord-017640-i8h48ny6	15	41	to	to	IN
cord-017640-i8h48ny6	15	42	death	death	NN
cord-017640-i8h48ny6	15	43	receptors	receptor	NNS
cord-017640-i8h48ny6	15	44	present	present	JJ
cord-017640-i8h48ny6	15	45	at	at	IN
cord-017640-i8h48ny6	15	46	the	the	DT
cord-017640-i8h48ny6	15	47	cell	cell	NN
cord-017640-i8h48ny6	15	48	surface	surface	NN
cord-017640-i8h48ny6	15	49	.	.	.
cord-017640-i8h48ny6	16	1	Interconnections	interconnection	NNS
cord-017640-i8h48ny6	16	2	exist	exist	VBP
cord-017640-i8h48ny6	16	3	between	between	IN
cord-017640-i8h48ny6	16	4	these	these	DT
cord-017640-i8h48ny6	16	5	two	two	CD
cord-017640-i8h48ny6	16	6	signaling	signal	VBG
cord-017640-i8h48ny6	16	7	pathways	pathway	NNS
cord-017640-i8h48ny6	16	8	:	:	:
cord-017640-i8h48ny6	16	9	both	both	DT
cord-017640-i8h48ny6	16	10	leading	lead	VBG
cord-017640-i8h48ny6	16	11	to	to	IN
cord-017640-i8h48ny6	16	12	the	the	DT
cord-017640-i8h48ny6	16	13	activation	activation	NN
cord-017640-i8h48ny6	16	14	of	of	IN
cord-017640-i8h48ny6	16	15	a	a	DT
cord-017640-i8h48ny6	16	16	family	family	NN
cord-017640-i8h48ny6	16	17	of	of	IN
cord-017640-i8h48ny6	16	18	cysteine	cysteine	NN
cord-017640-i8h48ny6	16	19	proteases	protease	NNS
cord-017640-i8h48ny6	16	20	specific	specific	JJ
cord-017640-i8h48ny6	16	21	for	for	IN
cord-017640-i8h48ny6	16	22	aspartic	aspartic	JJ
cord-017640-i8h48ny6	16	23	acid	acid	NN
cord-017640-i8h48ny6	16	24	residues	residue	NNS
cord-017640-i8h48ny6	16	25	,	,	,
cord-017640-i8h48ny6	16	26	called	call	VBN
cord-017640-i8h48ny6	16	27	caspases	caspase	NNS
cord-017640-i8h48ny6	16	28	[	[	-LRB-
cord-017640-i8h48ny6	16	29	5	5	CD
cord-017640-i8h48ny6	16	30	]	]	-RRB-
cord-017640-i8h48ny6	16	31	.	.	.
cord-017640-i8h48ny6	17	1	The	the	DT
cord-017640-i8h48ny6	17	2	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	17	3	role	role	NN
cord-017640-i8h48ny6	17	4	of	of	IN
cord-017640-i8h48ny6	17	5	mitochondria	mitochondrion	NNS
cord-017640-i8h48ny6	17	6	is	be	VBZ
cord-017640-i8h48ny6	17	7	associated	associate	VBN
cord-017640-i8h48ny6	17	8	with	with	IN
cord-017640-i8h48ny6	17	9	reduction	reduction	NN
cord-017640-i8h48ny6	17	10	in	in	IN
cord-017640-i8h48ny6	17	11	its	-PRON-	PRP$
cord-017640-i8h48ny6	17	12	transmembrane	transmembrane	NN
cord-017640-i8h48ny6	17	13	potential	potential	NN
cord-017640-i8h48ny6	17	14	and	and	CC
cord-017640-i8h48ny6	17	15	the	the	DT
cord-017640-i8h48ny6	17	16	loss	loss	NN
cord-017640-i8h48ny6	17	17	of	of	IN
cord-017640-i8h48ny6	17	18	its	-PRON-	PRP$
cord-017640-i8h48ny6	17	19	extracellular	extracellular	JJ
cord-017640-i8h48ny6	17	20	membrane	membrane	NN
cord-017640-i8h48ny6	17	21	integrity	integrity	NN
cord-017640-i8h48ny6	17	22	,	,	,
cord-017640-i8h48ny6	17	23	leading	lead	VBG
cord-017640-i8h48ny6	17	24	to	to	IN
cord-017640-i8h48ny6	17	25	the	the	DT
cord-017640-i8h48ny6	17	26	release	release	NN
cord-017640-i8h48ny6	17	27	of	of	IN
cord-017640-i8h48ny6	17	28	different	different	JJ
cord-017640-i8h48ny6	17	29	apoptogenic	apoptogenic	JJ
cord-017640-i8h48ny6	17	30	factors	factor	NNS
cord-017640-i8h48ny6	17	31	in	in	IN
cord-017640-i8h48ny6	17	32	the	the	DT
cord-017640-i8h48ny6	17	33	cytosol	cytosol	NN
cord-017640-i8h48ny6	17	34	.	.	.
cord-017640-i8h48ny6	18	1	Among	among	IN
cord-017640-i8h48ny6	18	2	them	-PRON-	PRP
cord-017640-i8h48ny6	18	3	,	,	,
cord-017640-i8h48ny6	18	4	cytochrome	cytochrome	NN
cord-017640-i8h48ny6	18	5	c	c	NN
cord-017640-i8h48ny6	18	6	associates	associate	NNS
cord-017640-i8h48ny6	18	7	with	with	IN
cord-017640-i8h48ny6	18	8	the	the	DT
cord-017640-i8h48ny6	18	9	caspase-9	caspase-9	NNP
cord-017640-i8h48ny6	18	10	/	/	SYM
cord-017640-i8h48ny6	18	11	APAF-1	APAF-1	NNP
cord-017640-i8h48ny6	18	12	complex	complex	NN
cord-017640-i8h48ny6	18	13	to	to	TO
cord-017640-i8h48ny6	18	14	form	form	VB
cord-017640-i8h48ny6	18	15	the	the	DT
cord-017640-i8h48ny6	18	16	apoptosome	apoptosome	NN
cord-017640-i8h48ny6	18	17	and	and	CC
cord-017640-i8h48ny6	18	18	trigger	trigger	NN
cord-017640-i8h48ny6	18	19	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	18	20	[	[	-LRB-
cord-017640-i8h48ny6	18	21	6	6	CD
cord-017640-i8h48ny6	18	22	]	]	-RRB-
cord-017640-i8h48ny6	18	23	.	.	.
cord-017640-i8h48ny6	19	1	These	these	DT
cord-017640-i8h48ny6	19	2	two	two	CD
cord-017640-i8h48ny6	19	3	signaling	signal	VBG
cord-017640-i8h48ny6	19	4	pathways	pathway	NNS
cord-017640-i8h48ny6	19	5	share	share	VBP
cord-017640-i8h48ny6	19	6	common	common	JJ
cord-017640-i8h48ny6	19	7	features	feature	NNS
cord-017640-i8h48ny6	19	8	,	,	,
cord-017640-i8h48ny6	19	9	and	and	CC
cord-017640-i8h48ny6	19	10	both	both	DT
cord-017640-i8h48ny6	19	11	require	require	VBP
cord-017640-i8h48ny6	19	12	the	the	DT
cord-017640-i8h48ny6	19	13	aggregation	aggregation	NN
cord-017640-i8h48ny6	19	14	of	of	IN
cord-017640-i8h48ny6	19	15	initiator	initiator	NN
cord-017640-i8h48ny6	19	16	caspases	caspase	NNS
cord-017640-i8h48ny6	19	17	as	as	IN
cord-017640-i8h48ny6	19	18	their	-PRON-	PRP$
cord-017640-i8h48ny6	19	19	preliminary	preliminary	JJ
cord-017640-i8h48ny6	19	20	events	event	NNS
cord-017640-i8h48ny6	19	21	.	.	.
cord-017640-i8h48ny6	20	1	During	during	IN
cord-017640-i8h48ny6	20	2	interactions	interaction	NNS
cord-017640-i8h48ny6	20	3	with	with	IN
cord-017640-i8h48ny6	20	4	respective	respective	JJ
cord-017640-i8h48ny6	20	5	ligands	ligand	NNS
cord-017640-i8h48ny6	20	6	,	,	,
cord-017640-i8h48ny6	20	7	members	member	NNS
cord-017640-i8h48ny6	20	8	of	of	IN
cord-017640-i8h48ny6	20	9	the	the	DT
cord-017640-i8h48ny6	20	10	death	death	NN
cord-017640-i8h48ny6	20	11	receptor	receptor	NN
cord-017640-i8h48ny6	20	12	superfamily	superfamily	NN
cord-017640-i8h48ny6	20	13	recruit	recruit	VBP
cord-017640-i8h48ny6	20	14	adaptor	adaptor	NN
cord-017640-i8h48ny6	20	15	proteins	protein	NNS
cord-017640-i8h48ny6	20	16	such	such	JJ
cord-017640-i8h48ny6	20	17	as	as	IN
cord-017640-i8h48ny6	20	18	Fas	Fas	NNP
cord-017640-i8h48ny6	20	19	-	-	HYPH
cord-017640-i8h48ny6	20	20	associated	associate	VBN
cord-017640-i8h48ny6	20	21	protein	protein	NN
cord-017640-i8h48ny6	20	22	with	with	IN
cord-017640-i8h48ny6	20	23	a	a	DT
cord-017640-i8h48ny6	20	24	death	death	NN
cord-017640-i8h48ny6	20	25	domain	domain	NN
cord-017640-i8h48ny6	20	26	(	(	-LRB-
cord-017640-i8h48ny6	20	27	FADD	FADD	NNP
cord-017640-i8h48ny6	20	28	)	)	-RRB-
cord-017640-i8h48ny6	20	29	[	[	-LRB-
cord-017640-i8h48ny6	20	30	7	7	CD
cord-017640-i8h48ny6	20	31	,	,	,
cord-017640-i8h48ny6	20	32	8	8	CD
cord-017640-i8h48ny6	20	33	]	]	-RRB-
cord-017640-i8h48ny6	20	34	or	or	CC
cord-017640-i8h48ny6	20	35	tumor	tumor	NN
cord-017640-i8h48ny6	20	36	necrosis	necrosis	NN
cord-017640-i8h48ny6	20	37	factor	factor	NN
cord-017640-i8h48ny6	20	38	(	(	-LRB-
cord-017640-i8h48ny6	20	39	TNF	TNF	NNP
cord-017640-i8h48ny6	20	40	)	)	-RRB-
cord-017640-i8h48ny6	20	41	receptor	receptor	NN
cord-017640-i8h48ny6	20	42	1-associated	1-associated	CD
cord-017640-i8h48ny6	20	43	death	death	NN
cord-017640-i8h48ny6	20	44	domain	domain	NN
cord-017640-i8h48ny6	20	45	protein	protein	NN
cord-017640-i8h48ny6	20	46	(	(	-LRB-
cord-017640-i8h48ny6	20	47	TRADD	TRADD	NNP
cord-017640-i8h48ny6	20	48	)	)	-RRB-
cord-017640-i8h48ny6	20	49	[	[	-LRB-
cord-017640-i8h48ny6	20	50	9	9	CD
cord-017640-i8h48ny6	20	51	]	]	-RRB-
cord-017640-i8h48ny6	20	52	,	,	,
cord-017640-i8h48ny6	20	53	resulting	result	VBG
cord-017640-i8h48ny6	20	54	in	in	IN
cord-017640-i8h48ny6	20	55	the	the	DT
cord-017640-i8h48ny6	20	56	aggregation	aggregation	NN
cord-017640-i8h48ny6	20	57	and	and	CC
cord-017640-i8h48ny6	20	58	activation	activation	NN
cord-017640-i8h48ny6	20	59	of	of	IN
cord-017640-i8h48ny6	20	60	the	the	DT
cord-017640-i8h48ny6	20	61	initiators	initiator	NNS
cord-017640-i8h48ny6	20	62	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	20	63	and	and	CC
cord-017640-i8h48ny6	20	64	caspase-10	caspase-10	NN
cord-017640-i8h48ny6	20	65	to	to	TO
cord-017640-i8h48ny6	20	66	form	form	VB
cord-017640-i8h48ny6	20	67	the	the	DT
cord-017640-i8h48ny6	20	68	death	death	NN
cord-017640-i8h48ny6	20	69	-	-	HYPH
cord-017640-i8h48ny6	20	70	inducing	induce	VBG
cord-017640-i8h48ny6	20	71	signaling	signal	VBG
cord-017640-i8h48ny6	20	72	complex	complex	NN
cord-017640-i8h48ny6	20	73	(	(	-LRB-
cord-017640-i8h48ny6	20	74	DISC	disc	NN
cord-017640-i8h48ny6	20	75	)	)	-RRB-
cord-017640-i8h48ny6	20	76	[	[	-LRB-
cord-017640-i8h48ny6	20	77	10	10	CD
cord-017640-i8h48ny6	20	78	]	]	-RRB-
cord-017640-i8h48ny6	20	79	.	.	.
cord-017640-i8h48ny6	21	1	In	in	IN
cord-017640-i8h48ny6	21	2	a	a	DT
cord-017640-i8h48ny6	21	3	similar	similar	JJ
cord-017640-i8h48ny6	21	4	manner	manner	NN
cord-017640-i8h48ny6	21	5	,	,	,
cord-017640-i8h48ny6	21	6	release	release	NN
cord-017640-i8h48ny6	21	7	of	of	IN
cord-017640-i8h48ny6	21	8	cytochrome	cytochrome	NN
cord-017640-i8h48ny6	21	9	c	c	NN
cord-017640-i8h48ny6	21	10	and	and	CC
cord-017640-i8h48ny6	21	11	ATP	ATP	NNP
cord-017640-i8h48ny6	21	12	by	by	IN
cord-017640-i8h48ny6	21	13	mitochondria	mitochondrion	NNS
cord-017640-i8h48ny6	21	14	promotes	promote	VBZ
cord-017640-i8h48ny6	21	15	the	the	DT
cord-017640-i8h48ny6	21	16	formation	formation	NN
cord-017640-i8h48ny6	21	17	of	of	IN
cord-017640-i8h48ny6	21	18	the	the	DT
cord-017640-i8h48ny6	21	19	apoptosome	apoptosome	NN
cord-017640-i8h48ny6	21	20	with	with	IN
cord-017640-i8h48ny6	21	21	the	the	DT
cord-017640-i8h48ny6	21	22	cytosolic	cytosolic	JJ
cord-017640-i8h48ny6	21	23	APAF-1	APAF-1	NNP
cord-017640-i8h48ny6	21	24	,	,	,
cord-017640-i8h48ny6	21	25	thereby	thereby	RB
cord-017640-i8h48ny6	21	26	aggregating	aggregate	VBG
cord-017640-i8h48ny6	21	27	and	and	CC
cord-017640-i8h48ny6	21	28	activating	activate	VBG
cord-017640-i8h48ny6	21	29	the	the	DT
cord-017640-i8h48ny6	21	30	initiator	initiator	NN
cord-017640-i8h48ny6	21	31	caspase-9	caspase-9	NNP
cord-017640-i8h48ny6	21	32	,	,	,
cord-017640-i8h48ny6	21	33	which	which	WDT
cord-017640-i8h48ny6	21	34	in	in	IN
cord-017640-i8h48ny6	21	35	turn	turn	NN
cord-017640-i8h48ny6	21	36	cleaves	cleave	VBZ
cord-017640-i8h48ny6	21	37	caspase-3	caspase-3	NNP
cord-017640-i8h48ny6	21	38	[	[	-LRB-
cord-017640-i8h48ny6	21	39	11	11	CD
cord-017640-i8h48ny6	21	40	]	]	-RRB-
cord-017640-i8h48ny6	21	41	.	.	.
cord-017640-i8h48ny6	22	1	It	-PRON-	PRP
cord-017640-i8h48ny6	22	2	should	should	MD
cord-017640-i8h48ny6	22	3	be	be	VB
cord-017640-i8h48ny6	22	4	kept	keep	VBN
cord-017640-i8h48ny6	22	5	in	in	IN
cord-017640-i8h48ny6	22	6	mind	mind	NN
cord-017640-i8h48ny6	22	7	that	that	IN
cord-017640-i8h48ny6	22	8	death	death	NN
cord-017640-i8h48ny6	22	9	receptors	receptor	NNS
cord-017640-i8h48ny6	22	10	CD95	CD95	NNP
cord-017640-i8h48ny6	22	11	[	[	-LRB-
cord-017640-i8h48ny6	22	12	12	12	CD
cord-017640-i8h48ny6	22	13	]	]	-RRB-
cord-017640-i8h48ny6	22	14	,	,	.
cord-017640-i8h48ny6	23	1	TNFR1	tnfr1	XX
cord-017640-i8h48ny6	24	1	[	[	-LRB-
cord-017640-i8h48ny6	24	2	13	13	CD
cord-017640-i8h48ny6	24	3	]	]	-RRB-
cord-017640-i8h48ny6	24	4	,	,	,
cord-017640-i8h48ny6	24	5	DR4	DR4	NNP
cord-017640-i8h48ny6	24	6	[	[	-LRB-
cord-017640-i8h48ny6	24	7	14	14	CD
cord-017640-i8h48ny6	24	8	]	]	-RRB-
cord-017640-i8h48ny6	24	9	,	,	,
cord-017640-i8h48ny6	24	10	DR5	DR5	NNP
cord-017640-i8h48ny6	24	11	[	[	-LRB-
cord-017640-i8h48ny6	24	12	15	15	CD
cord-017640-i8h48ny6	24	13	]	]	-RRB-
cord-017640-i8h48ny6	24	14	,	,	,
cord-017640-i8h48ny6	24	15	and	and	CC
cord-017640-i8h48ny6	24	16	DR6	DR6	NNP
cord-017640-i8h48ny6	24	17	[	[	-LRB-
cord-017640-i8h48ny6	24	18	16	16	CD
cord-017640-i8h48ny6	24	19	]	]	-RRB-
cord-017640-i8h48ny6	24	20	have	have	VBP
cord-017640-i8h48ny6	24	21	been	be	VBN
cord-017640-i8h48ny6	24	22	cloned	clone	VBN
cord-017640-i8h48ny6	24	23	based	base	VBN
cord-017640-i8h48ny6	24	24	on	on	IN
cord-017640-i8h48ny6	24	25	their	-PRON-	PRP$
cord-017640-i8h48ny6	24	26	ability	ability	NN
cord-017640-i8h48ny6	24	27	to	to	TO
cord-017640-i8h48ny6	24	28	elicit	elicit	VB
cord-017640-i8h48ny6	24	29	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	24	30	.	.	.
cord-017640-i8h48ny6	25	1	Although	although	IN
cord-017640-i8h48ny6	25	2	studies	study	NNS
cord-017640-i8h48ny6	25	3	have	have	VBP
cord-017640-i8h48ny6	25	4	revealed	reveal	VBN
cord-017640-i8h48ny6	25	5	the	the	DT
cord-017640-i8h48ny6	25	6	ability	ability	NN
cord-017640-i8h48ny6	25	7	of	of	IN
cord-017640-i8h48ny6	25	8	Fas	Fas	NNP
cord-017640-i8h48ny6	25	9	/	/	SYM
cord-017640-i8h48ny6	25	10	CD95	CD95	NNP
cord-017640-i8h48ny6	25	11	,	,	,
cord-017640-i8h48ny6	25	12	DR4	dr4	NN
cord-017640-i8h48ny6	25	13	,	,	,
cord-017640-i8h48ny6	25	14	and	and	CC
cord-017640-i8h48ny6	25	15	DR5	DR5	NNP
cord-017640-i8h48ny6	25	16	in	in	IN
cord-017640-i8h48ny6	25	17	triggering	trigger	VBG
cord-017640-i8h48ny6	25	18	non	non	JJ
cord-017640-i8h48ny6	25	19	-	-	JJ
cord-017640-i8h48ny6	25	20	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	25	21	signaling	signal	VBG
cord-017640-i8h48ny6	25	22	pathways	pathway	NNS
cord-017640-i8h48ny6	25	23	even	even	RB
cord-017640-i8h48ny6	25	24	immediately	immediately	RB
cord-017640-i8h48ny6	25	25	after	after	IN
cord-017640-i8h48ny6	25	26	their	-PRON-	PRP$
cord-017640-i8h48ny6	25	27	cloning	clone	VBG
cord-017640-i8h48ny6	25	28	[	[	-LRB-
cord-017640-i8h48ny6	25	29	17	17	CD
cord-017640-i8h48ny6	25	30	,	,	,
cord-017640-i8h48ny6	25	31	18	18	CD
cord-017640-i8h48ny6	25	32	]	]	-RRB-
cord-017640-i8h48ny6	25	33	,	,	,
cord-017640-i8h48ny6	25	34	most	most	JJS
cord-017640-i8h48ny6	25	35	,	,	,
cord-017640-i8h48ny6	25	36	if	if	IN
cord-017640-i8h48ny6	25	37	not	not	RB
cord-017640-i8h48ny6	25	38	all	all	DT
cord-017640-i8h48ny6	25	39	,	,	,
cord-017640-i8h48ny6	25	40	studies	study	NNS
cord-017640-i8h48ny6	25	41	have	have	VBP
cord-017640-i8h48ny6	25	42	been	be	VBN
cord-017640-i8h48ny6	25	43	focused	focus	VBN
cord-017640-i8h48ny6	25	44	on	on	IN
cord-017640-i8h48ny6	25	45	characterizing	characterize	VBG
cord-017640-i8h48ny6	25	46	the	the	DT
cord-017640-i8h48ny6	25	47	molecular	molecular	JJ
cord-017640-i8h48ny6	25	48	events	event	NNS
cord-017640-i8h48ny6	25	49	leading	lead	VBG
cord-017640-i8h48ny6	25	50	to	to	IN
cord-017640-i8h48ny6	25	51	cell	cell	NN
cord-017640-i8h48ny6	25	52	death	death	NN
cord-017640-i8h48ny6	25	53	.	.	.
cord-017640-i8h48ny6	26	1	Accordingly	accordingly	RB
cord-017640-i8h48ny6	26	2	,	,	,
cord-017640-i8h48ny6	26	3	several	several	JJ
cord-017640-i8h48ny6	26	4	agonistic	agonistic	JJ
cord-017640-i8h48ny6	26	5	molecules	molecule	NNS
cord-017640-i8h48ny6	26	6	were	be	VBD
cord-017640-i8h48ny6	26	7	developed	develop	VBN
cord-017640-i8h48ny6	26	8	in	in	IN
cord-017640-i8h48ny6	26	9	order	order	NN
cord-017640-i8h48ny6	26	10	to	to	TO
cord-017640-i8h48ny6	26	11	kill	kill	VB
cord-017640-i8h48ny6	26	12	cancer	cancer	NN
cord-017640-i8h48ny6	26	13	cells	cell	NNS
cord-017640-i8h48ny6	26	14	,	,	,
cord-017640-i8h48ny6	26	15	neglecting	neglect	VBG
cord-017640-i8h48ny6	26	16	the	the	DT
cord-017640-i8h48ny6	26	17	impact	impact	NN
cord-017640-i8h48ny6	26	18	of	of	IN
cord-017640-i8h48ny6	26	19	non	non	JJ
cord-017640-i8h48ny6	26	20	-	-	JJ
cord-017640-i8h48ny6	26	21	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	26	22	signals	signal	NNS
cord-017640-i8h48ny6	26	23	in	in	IN
cord-017640-i8h48ny6	26	24	pathophysiological	pathophysiological	JJ
cord-017640-i8h48ny6	26	25	contexts	context	NNS
cord-017640-i8h48ny6	26	26	.	.	.
cord-017640-i8h48ny6	27	1	More	More	JJR
cord-017640-i8h48ny6	27	2	recent	recent	JJ
cord-017640-i8h48ny6	27	3	data	datum	NNS
cord-017640-i8h48ny6	27	4	changed	change	VBD
cord-017640-i8h48ny6	27	5	this	this	DT
cord-017640-i8h48ny6	27	6	vision	vision	NN
cord-017640-i8h48ny6	27	7	by	by	IN
cord-017640-i8h48ny6	27	8	evaluating	evaluate	VBG
cord-017640-i8h48ny6	27	9	the	the	DT
cord-017640-i8h48ny6	27	10	biological	biological	JJ
cord-017640-i8h48ny6	27	11	role	role	NN
cord-017640-i8h48ny6	27	12	of	of	IN
cord-017640-i8h48ny6	27	13	death	death	NN
cord-017640-i8h48ny6	27	14	receptor	receptor	NN
cord-017640-i8h48ny6	27	15	-	-	HYPH
cord-017640-i8h48ny6	27	16	mediated	mediate	VBN
cord-017640-i8h48ny6	27	17	non	non	JJ
cord-017640-i8h48ny6	27	18	-	-	JJ
cord-017640-i8h48ny6	27	19	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	27	20	signaling	signal	VBG
cord-017640-i8h48ny6	27	21	pathways	pathway	NNS
cord-017640-i8h48ny6	27	22	in	in	IN
cord-017640-i8h48ny6	27	23	chronic	chronic	JJ
cord-017640-i8h48ny6	27	24	inflammatory	inflammatory	JJ
cord-017640-i8h48ny6	27	25	disorders	disorder	NNS
cord-017640-i8h48ny6	27	26	and	and	CC
cord-017640-i8h48ny6	27	27	carcinogenesis	carcinogenesis	NN
cord-017640-i8h48ny6	27	28	.	.	.
cord-017640-i8h48ny6	28	1	In	in	IN
cord-017640-i8h48ny6	28	2	this	this	DT
cord-017640-i8h48ny6	28	3	chapter	chapter	NN
cord-017640-i8h48ny6	28	4	,	,	,
cord-017640-i8h48ny6	28	5	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	28	6	signaling	signal	VBG
cord-017640-i8h48ny6	28	7	pathways	pathway	NNS
cord-017640-i8h48ny6	28	8	induced	induce	VBN
cord-017640-i8h48ny6	28	9	by	by	IN
cord-017640-i8h48ny6	28	10	death	death	NN
cord-017640-i8h48ny6	28	11	receptors	receptor	NNS
cord-017640-i8h48ny6	28	12	are	be	VBP
cord-017640-i8h48ny6	28	13	discussed	discuss	VBN
cord-017640-i8h48ny6	28	14	.	.	.
cord-017640-i8h48ny6	29	1	Moreover	moreover	RB
cord-017640-i8h48ny6	29	2	,	,	,
cord-017640-i8h48ny6	29	3	recent	recent	JJ
cord-017640-i8h48ny6	29	4	evidences	evidence	NNS
cord-017640-i8h48ny6	29	5	pointing	point	VBG
cord-017640-i8h48ny6	29	6	to	to	IN
cord-017640-i8h48ny6	29	7	the	the	DT
cord-017640-i8h48ny6	29	8	non	non	JJ
cord-017640-i8h48ny6	29	9	-	-	JJ
cord-017640-i8h48ny6	29	10	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	29	11	signals	signal	NNS
cord-017640-i8h48ny6	29	12	transmitted	transmit	VBN
cord-017640-i8h48ny6	29	13	by	by	IN
cord-017640-i8h48ny6	29	14	the	the	DT
cord-017640-i8h48ny6	29	15	same	same	JJ
cord-017640-i8h48ny6	29	16	receptors	receptor	NNS
cord-017640-i8h48ny6	29	17	are	be	VBP
cord-017640-i8h48ny6	29	18	brought	bring	VBN
cord-017640-i8h48ny6	29	19	up	up	RP
cord-017640-i8h48ny6	29	20	,	,	,
cord-017640-i8h48ny6	29	21	which	which	WDT
cord-017640-i8h48ny6	29	22	may	may	MD
cord-017640-i8h48ny6	29	23	imply	imply	VB
cord-017640-i8h48ny6	29	24	their	-PRON-	PRP$
cord-017640-i8h48ny6	29	25	tremendous	tremendous	JJ
cord-017640-i8h48ny6	29	26	impact	impact	NN
cord-017640-i8h48ny6	29	27	on	on	IN
cord-017640-i8h48ny6	29	28	tumor	tumor	NN
cord-017640-i8h48ny6	29	29	progression	progression	NN
cord-017640-i8h48ny6	29	30	and	and	CC
cord-017640-i8h48ny6	29	31	the	the	DT
cord-017640-i8h48ny6	29	32	design	design	NN
cord-017640-i8h48ny6	29	33	of	of	IN
cord-017640-i8h48ny6	29	34	therapeutic	therapeutic	JJ
cord-017640-i8h48ny6	29	35	tools	tool	NNS
cord-017640-i8h48ny6	29	36	.	.	.
cord-017640-i8h48ny6	30	1	Death	death	NN
cord-017640-i8h48ny6	30	2	receptors	receptor	NNS
cord-017640-i8h48ny6	31	1	TNFR1	TNFR1	NNP
cord-017640-i8h48ny6	31	2	,	,	,
cord-017640-i8h48ny6	32	1	Fas	Fas	NNP
cord-017640-i8h48ny6	32	2	,	,	,
cord-017640-i8h48ny6	32	3	DR3	DR3	NNP
cord-017640-i8h48ny6	32	4	,	,	,
cord-017640-i8h48ny6	32	5	DR4	DR4	NNP
cord-017640-i8h48ny6	32	6	,	,	,
cord-017640-i8h48ny6	32	7	DR5	DR5	NNP
cord-017640-i8h48ny6	32	8	,	,	,
cord-017640-i8h48ny6	32	9	and	and	CC
cord-017640-i8h48ny6	32	10	DR6	dr6	NN
cord-017640-i8h48ny6	32	11	belong	belong	VBP
cord-017640-i8h48ny6	32	12	to	to	IN
cord-017640-i8h48ny6	32	13	the	the	DT
cord-017640-i8h48ny6	32	14	tumor	tumor	NN
cord-017640-i8h48ny6	32	15	necrosis	necrosis	NN
cord-017640-i8h48ny6	32	16	factor	factor	NN
cord-017640-i8h48ny6	32	17	receptor	receptor	NN
cord-017640-i8h48ny6	32	18	(	(	-LRB-
cord-017640-i8h48ny6	32	19	TNFR	TNFR	NNP
cord-017640-i8h48ny6	32	20	)	)	-RRB-
cord-017640-i8h48ny6	32	21	superfamily	superfamily	NN
cord-017640-i8h48ny6	32	22	.	.	.
cord-017640-i8h48ny6	33	1	These	these	DT
cord-017640-i8h48ny6	33	2	type	type	NN
cord-017640-i8h48ny6	33	3	I	-PRON-	PRP
cord-017640-i8h48ny6	33	4	transmembrane	transmembrane	NN
cord-017640-i8h48ny6	33	5	proteins	protein	NNS
cord-017640-i8h48ny6	33	6	share	share	VBP
cord-017640-i8h48ny6	33	7	common	common	JJ
cord-017640-i8h48ny6	33	8	features	feature	NNS
cord-017640-i8h48ny6	33	9	,	,	,
cord-017640-i8h48ny6	33	10	such	such	JJ
cord-017640-i8h48ny6	33	11	as	as	IN
cord-017640-i8h48ny6	33	12	extracellular	extracellular	JJ
cord-017640-i8h48ny6	33	13	amino	amino	NN
cord-017640-i8h48ny6	33	14	-	-	HYPH
cord-017640-i8h48ny6	33	15	terminal	terminal	NN
cord-017640-i8h48ny6	33	16	cysteine	cysteine	NN
cord-017640-i8h48ny6	33	17	-	-	HYPH
cord-017640-i8h48ny6	33	18	rich	rich	JJ
cord-017640-i8h48ny6	33	19	domains	domain	NNS
cord-017640-i8h48ny6	33	20	(	(	-LRB-
cord-017640-i8h48ny6	33	21	CRDs	CRDs	NNP
cord-017640-i8h48ny6	33	22	)	)	-RRB-
cord-017640-i8h48ny6	33	23	[	[	-LRB-
cord-017640-i8h48ny6	33	24	19	19	CD
cord-017640-i8h48ny6	33	25	,	,	,
cord-017640-i8h48ny6	33	26	20	20	CD
cord-017640-i8h48ny6	33	27	]	]	-RRB-
cord-017640-i8h48ny6	33	28	,	,	,
cord-017640-i8h48ny6	33	29	which	which	WDT
cord-017640-i8h48ny6	33	30	contribute	contribute	VBP
cord-017640-i8h48ny6	33	31	to	to	IN
cord-017640-i8h48ny6	33	32	ligand	ligand	NN
cord-017640-i8h48ny6	33	33	specificity	specificity	NN
cord-017640-i8h48ny6	33	34	[	[	-LRB-
cord-017640-i8h48ny6	33	35	21	21	CD
cord-017640-i8h48ny6	33	36	]	]	-RRB-
cord-017640-i8h48ny6	33	37	,	,	,
cord-017640-i8h48ny6	33	38	and	and	CC
cord-017640-i8h48ny6	33	39	pre	pre	JJ
cord-017640-i8h48ny6	33	40	-	-	JJ
cord-017640-i8h48ny6	33	41	association	association	NN
cord-017640-i8h48ny6	33	42	of	of	IN
cord-017640-i8h48ny6	33	43	the	the	DT
cord-017640-i8h48ny6	33	44	receptor	receptor	NN
cord-017640-i8h48ny6	33	45	at	at	IN
cord-017640-i8h48ny6	33	46	the	the	DT
cord-017640-i8h48ny6	33	47	plasma	plasma	NN
cord-017640-i8h48ny6	33	48	membrane	membrane	NN
cord-017640-i8h48ny6	33	49	[	[	-LRB-
cord-017640-i8h48ny6	33	50	22	22	CD
cord-017640-i8h48ny6	33	51	]	]	-RRB-
cord-017640-i8h48ny6	33	52	[	[	-LRB-
cord-017640-i8h48ny6	33	53	23	23	CD
cord-017640-i8h48ny6	33	54	]	]	-RRB-
cord-017640-i8h48ny6	33	55	[	[	-LRB-
cord-017640-i8h48ny6	33	56	24	24	CD
cord-017640-i8h48ny6	33	57	]	]	-RRB-
cord-017640-i8h48ny6	33	58	and	and	CC
cord-017640-i8h48ny6	33	59	a	a	DT
cord-017640-i8h48ny6	33	60	conserved	conserved	JJ
cord-017640-i8h48ny6	33	61	80-amino	80-amino	CD
cord-017640-i8h48ny6	33	62	acid	acid	NN
cord-017640-i8h48ny6	33	63	sequence	sequence	NN
cord-017640-i8h48ny6	33	64	located	locate	VBN
cord-017640-i8h48ny6	33	65	in	in	IN
cord-017640-i8h48ny6	33	66	their	-PRON-	PRP$
cord-017640-i8h48ny6	33	67	cytoplasmic	cytoplasmic	JJ
cord-017640-i8h48ny6	33	68	tail	tail	NN
cord-017640-i8h48ny6	33	69	called	call	VBN
cord-017640-i8h48ny6	33	70	death	death	NN
cord-017640-i8h48ny6	33	71	domain	domain	NN
cord-017640-i8h48ny6	33	72	(	(	-LRB-
cord-017640-i8h48ny6	33	73	DD	DD	NNP
cord-017640-i8h48ny6	33	74	)	)	-RRB-
cord-017640-i8h48ny6	33	75	,	,	,
cord-017640-i8h48ny6	33	76	which	which	WDT
cord-017640-i8h48ny6	33	77	is	be	VBZ
cord-017640-i8h48ny6	33	78	necessary	necessary	JJ
cord-017640-i8h48ny6	33	79	for	for	IN
cord-017640-i8h48ny6	33	80	DISC	disc	NN
cord-017640-i8h48ny6	33	81	formation	formation	NN
cord-017640-i8h48ny6	33	82	and	and	CC
cord-017640-i8h48ny6	33	83	initiation	initiation	NN
cord-017640-i8h48ny6	33	84	of	of	IN
cord-017640-i8h48ny6	33	85	the	the	DT
cord-017640-i8h48ny6	33	86	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	33	87	signal	signal	NN
cord-017640-i8h48ny6	33	88	[	[	-LRB-
cord-017640-i8h48ny6	33	89	25	25	CD
cord-017640-i8h48ny6	33	90	,	,	,
cord-017640-i8h48ny6	33	91	26	26	CD
cord-017640-i8h48ny6	33	92	]	]	-RRB-
cord-017640-i8h48ny6	33	93	.	.	.
cord-017640-i8h48ny6	34	1	TNF	TNF	NNP
cord-017640-i8h48ny6	34	2	-	-	HYPH
cord-017640-i8h48ny6	34	3	α	α	NNP
cord-017640-i8h48ny6	34	4	exerts	exert	VBZ
cord-017640-i8h48ny6	34	5	its	-PRON-	PRP$
cord-017640-i8h48ny6	34	6	effects	effect	NNS
cord-017640-i8h48ny6	34	7	by	by	IN
cord-017640-i8h48ny6	34	8	binding	bind	VBG
cord-017640-i8h48ny6	34	9	to	to	IN
cord-017640-i8h48ny6	34	10	two	two	CD
cord-017640-i8h48ny6	34	11	receptors	receptor	NNS
cord-017640-i8h48ny6	34	12	,	,	,
cord-017640-i8h48ny6	35	1	TNFR1	TNFR1	NNP
cord-017640-i8h48ny6	35	2	and	and	CC
cord-017640-i8h48ny6	35	3	TNFR2	TNFR2	NNP
cord-017640-i8h48ny6	35	4	[	[	-LRB-
cord-017640-i8h48ny6	35	5	20	20	CD
cord-017640-i8h48ny6	35	6	]	]	-RRB-
cord-017640-i8h48ny6	35	7	.	.	.
cord-017640-i8h48ny6	36	1	Recently	recently	RB
cord-017640-i8h48ny6	36	2	,	,	,
cord-017640-i8h48ny6	36	3	progranulin	progranulin	NNP
cord-017640-i8h48ny6	36	4	was	be	VBD
cord-017640-i8h48ny6	36	5	identified	identify	VBN
cord-017640-i8h48ny6	36	6	as	as	IN
cord-017640-i8h48ny6	36	7	a	a	DT
cord-017640-i8h48ny6	36	8	ligand	ligand	NN
cord-017640-i8h48ny6	36	9	of	of	IN
cord-017640-i8h48ny6	36	10	TNFR	TNFR	NNP
cord-017640-i8h48ny6	36	11	with	with	IN
cord-017640-i8h48ny6	36	12	a	a	DT
cord-017640-i8h48ny6	36	13	higher	high	JJR
cord-017640-i8h48ny6	36	14	affinity	affinity	NN
cord-017640-i8h48ny6	36	15	than	than	IN
cord-017640-i8h48ny6	36	16	TNF	TNF	NNP
cord-017640-i8h48ny6	36	17	-	-	HYPH
cord-017640-i8h48ny6	36	18	α	α	NNP
cord-017640-i8h48ny6	36	19	.	.	.
cord-017640-i8h48ny6	37	1	Progranulin	Progranulin	NNP
cord-017640-i8h48ny6	37	2	antagonizes	antagonize	VBZ
cord-017640-i8h48ny6	37	3	TNF	TNF	NNP
cord-017640-i8h48ny6	37	4	-	-	HYPH
cord-017640-i8h48ny6	37	5	α	α	NNP
cord-017640-i8h48ny6	37	6	signaling	signaling	NN
cord-017640-i8h48ny6	37	7	and	and	CC
cord-017640-i8h48ny6	37	8	plays	play	VBZ
cord-017640-i8h48ny6	37	9	a	a	DT
cord-017640-i8h48ny6	37	10	critical	critical	JJ
cord-017640-i8h48ny6	37	11	role	role	NN
cord-017640-i8h48ny6	37	12	in	in	IN
cord-017640-i8h48ny6	37	13	the	the	DT
cord-017640-i8h48ny6	37	14	pathogenesis	pathogenesis	NN
cord-017640-i8h48ny6	37	15	of	of	IN
cord-017640-i8h48ny6	37	16	inflammatory	inflammatory	JJ
cord-017640-i8h48ny6	37	17	arthritis	arthritis	NN
cord-017640-i8h48ny6	37	18	in	in	IN
cord-017640-i8h48ny6	37	19	mice	mouse	NNS
cord-017640-i8h48ny6	37	20	[	[	-LRB-
cord-017640-i8h48ny6	37	21	27	27	CD
cord-017640-i8h48ny6	37	22	]	]	-RRB-
cord-017640-i8h48ny6	37	23	.	.	.
cord-017640-i8h48ny6	38	1	TNFR1	TNFR1	NNP
cord-017640-i8h48ny6	38	2	,	,	,
cord-017640-i8h48ny6	38	3	a	a	DT
cord-017640-i8h48ny6	38	4	55	55	CD
cord-017640-i8h48ny6	38	5	kDa	kDa	NNP
cord-017640-i8h48ny6	38	6	protein	protein	NN
cord-017640-i8h48ny6	38	7	expressed	express	VBD
cord-017640-i8h48ny6	38	8	in	in	IN
cord-017640-i8h48ny6	38	9	almost	almost	RB
cord-017640-i8h48ny6	38	10	all	all	DT
cord-017640-i8h48ny6	38	11	cell	cell	NN
cord-017640-i8h48ny6	38	12	types	type	NNS
cord-017640-i8h48ny6	38	13	,	,	,
cord-017640-i8h48ny6	38	14	presents	present	VBZ
cord-017640-i8h48ny6	38	15	a	a	DT
cord-017640-i8h48ny6	38	16	DD	dd	NN
cord-017640-i8h48ny6	38	17	in	in	IN
cord-017640-i8h48ny6	38	18	its	-PRON-	PRP$
cord-017640-i8h48ny6	38	19	intracellular	intracellular	JJ
cord-017640-i8h48ny6	38	20	region	region	NN
cord-017640-i8h48ny6	38	21	,	,	,
cord-017640-i8h48ny6	38	22	whereas	whereas	IN
cord-017640-i8h48ny6	38	23	TNFR2	TNFR2	NNP
cord-017640-i8h48ny6	38	24	,	,	,
cord-017640-i8h48ny6	38	25	a	a	DT
cord-017640-i8h48ny6	38	26	75	75	CD
cord-017640-i8h48ny6	38	27	kDa	kDa	NNP
cord-017640-i8h48ny6	38	28	protein	protein	NN
cord-017640-i8h48ny6	38	29	,	,	,
cord-017640-i8h48ny6	38	30	is	be	VBZ
cord-017640-i8h48ny6	38	31	mainly	mainly	RB
cord-017640-i8h48ny6	38	32	detected	detect	VBN
cord-017640-i8h48ny6	38	33	in	in	IN
cord-017640-i8h48ny6	38	34	oligodendrocytes	oligodendrocyte	NNS
cord-017640-i8h48ny6	38	35	,	,	,
cord-017640-i8h48ny6	38	36	astrocytes	astrocyte	NNS
cord-017640-i8h48ny6	38	37	,	,	,
cord-017640-i8h48ny6	38	38	T	t	NN
cord-017640-i8h48ny6	38	39	-	-	HYPH
cord-017640-i8h48ny6	38	40	cells	cell	NNS
cord-017640-i8h48ny6	38	41	,	,	,
cord-017640-i8h48ny6	38	42	myocytes	myocyte	NNS
cord-017640-i8h48ny6	38	43	,	,	,
cord-017640-i8h48ny6	38	44	thymocytes	thymocyte	NNS
cord-017640-i8h48ny6	38	45	,	,	,
cord-017640-i8h48ny6	38	46	endothelial	endothelial	JJ
cord-017640-i8h48ny6	38	47	cells	cell	NNS
cord-017640-i8h48ny6	38	48	,	,	,
cord-017640-i8h48ny6	38	49	and	and	CC
cord-017640-i8h48ny6	38	50	human	human	JJ
cord-017640-i8h48ny6	38	51	mesenchymal	mesenchymal	JJ
cord-017640-i8h48ny6	38	52	stem	stem	NN
cord-017640-i8h48ny6	38	53	cells	cell	NNS
cord-017640-i8h48ny6	38	54	[	[	-LRB-
cord-017640-i8h48ny6	38	55	28	28	CD
cord-017640-i8h48ny6	38	56	]	]	-RRB-
cord-017640-i8h48ny6	38	57	.	.	.
cord-017640-i8h48ny6	39	1	Uncertainty	uncertainty	NN
cord-017640-i8h48ny6	39	2	remains	remain	VBZ
cord-017640-i8h48ny6	39	3	on	on	IN
cord-017640-i8h48ny6	39	4	the	the	DT
cord-017640-i8h48ny6	39	5	TNFR2	tnfr2	NN
cord-017640-i8h48ny6	39	6	signaling	signal	VBG
cord-017640-i8h48ny6	39	7	pathway	pathway	NN
cord-017640-i8h48ny6	39	8	,	,	,
cord-017640-i8h48ny6	39	9	which	which	WDT
cord-017640-i8h48ny6	39	10	has	have	VBZ
cord-017640-i8h48ny6	39	11	been	be	VBN
cord-017640-i8h48ny6	39	12	previously	previously	RB
cord-017640-i8h48ny6	39	13	reviewed	review	VBN
cord-017640-i8h48ny6	39	14	[	[	-LRB-
cord-017640-i8h48ny6	39	15	28	28	CD
cord-017640-i8h48ny6	39	16	]	]	-RRB-
cord-017640-i8h48ny6	39	17	.	.	.
cord-017640-i8h48ny6	40	1	The	the	DT
cord-017640-i8h48ny6	40	2	CRD1	CRD1	NNP
cord-017640-i8h48ny6	40	3	of	of	IN
cord-017640-i8h48ny6	40	4	CD95	CD95	NNP
cord-017640-i8h48ny6	40	5	,	,	,
cord-017640-i8h48ny6	40	6	TNFR1	TNFR1	NNP
cord-017640-i8h48ny6	40	7	,	,	,
cord-017640-i8h48ny6	40	8	and	and	CC
cord-017640-i8h48ny6	40	9	TNFR2	tnfr2	NN
cord-017640-i8h48ny6	40	10	is	be	VBZ
cord-017640-i8h48ny6	40	11	involved	involve	VBN
cord-017640-i8h48ny6	40	12	in	in	IN
cord-017640-i8h48ny6	40	13	homotypic	homotypic	JJ
cord-017640-i8h48ny6	40	14	interactions	interaction	NNS
cord-017640-i8h48ny6	40	15	,	,	,
cord-017640-i8h48ny6	40	16	leading	lead	VBG
cord-017640-i8h48ny6	40	17	to	to	IN
cord-017640-i8h48ny6	40	18	pre	pre	VB
cord-017640-i8h48ny6	40	19	-	-	JJ
cord-017640-i8h48ny6	40	20	association	association	NN
cord-017640-i8h48ny6	40	21	of	of	IN
cord-017640-i8h48ny6	40	22	the	the	DT
cord-017640-i8h48ny6	40	23	receptor	receptor	NN
cord-017640-i8h48ny6	40	24	as	as	IN
cord-017640-i8h48ny6	40	25	a	a	DT
cord-017640-i8h48ny6	40	26	homotrimer	homotrimer	NN
cord-017640-i8h48ny6	40	27	in	in	IN
cord-017640-i8h48ny6	40	28	the	the	DT
cord-017640-i8h48ny6	40	29	absence	absence	NN
cord-017640-i8h48ny6	40	30	of	of	IN
cord-017640-i8h48ny6	40	31	ligand	ligand	NN
cord-017640-i8h48ny6	40	32	[	[	-LRB-
cord-017640-i8h48ny6	40	33	23	23	CD
cord-017640-i8h48ny6	40	34	,	,	,
cord-017640-i8h48ny6	40	35	24	24	CD
cord-017640-i8h48ny6	40	36	,	,	,
cord-017640-i8h48ny6	40	37	29	29	CD
cord-017640-i8h48ny6	40	38	]	]	-RRB-
cord-017640-i8h48ny6	40	39	.	.	.
cord-017640-i8h48ny6	41	1	This	this	DT
cord-017640-i8h48ny6	41	2	domain	domain	NN
cord-017640-i8h48ny6	41	3	has	have	VBZ
cord-017640-i8h48ny6	41	4	been	be	VBN
cord-017640-i8h48ny6	41	5	designated	designate	VBN
cord-017640-i8h48ny6	41	6	as	as	IN
cord-017640-i8h48ny6	41	7	the	the	DT
cord-017640-i8h48ny6	41	8	pre	pre	JJ
cord-017640-i8h48ny6	41	9	-	-	JJ
cord-017640-i8h48ny6	41	10	ligand	ligand	JJ
cord-017640-i8h48ny6	41	11	binding	binding	NN
cord-017640-i8h48ny6	41	12	assembly	assembly	NN
cord-017640-i8h48ny6	41	13	domain	domain	NN
cord-017640-i8h48ny6	41	14	(	(	-LRB-
cord-017640-i8h48ny6	41	15	PLAD	PLAD	NNP
cord-017640-i8h48ny6	41	16	)	)	-RRB-
cord-017640-i8h48ny6	41	17	[	[	-LRB-
cord-017640-i8h48ny6	41	18	29	29	CD
cord-017640-i8h48ny6	41	19	]	]	-RRB-
cord-017640-i8h48ny6	41	20	.	.	.
cord-017640-i8h48ny6	42	1	Receptors	receptor	NNS
cord-017640-i8h48ny6	42	2	of	of	IN
cord-017640-i8h48ny6	42	3	the	the	DT
cord-017640-i8h48ny6	42	4	TNFR	TNFR	NNP
cord-017640-i8h48ny6	42	5	superfamily	superfamily	NN
cord-017640-i8h48ny6	42	6	do	do	VBP
cord-017640-i8h48ny6	42	7	not	not	RB
cord-017640-i8h48ny6	42	8	possess	possess	VB
cord-017640-i8h48ny6	42	9	any	any	DT
cord-017640-i8h48ny6	42	10	enzymatic	enzymatic	JJ
cord-017640-i8h48ny6	42	11	activity	activity	NN
cord-017640-i8h48ny6	42	12	on	on	IN
cord-017640-i8h48ny6	42	13	their	-PRON-	PRP$
cord-017640-i8h48ny6	42	14	own	own	JJ
cord-017640-i8h48ny6	42	15	and	and	CC
cord-017640-i8h48ny6	42	16	rely	rely	VBP
cord-017640-i8h48ny6	42	17	on	on	IN
cord-017640-i8h48ny6	42	18	the	the	DT
cord-017640-i8h48ny6	42	19	recruitment	recruitment	NN
cord-017640-i8h48ny6	42	20	of	of	IN
cord-017640-i8h48ny6	42	21	adaptor	adaptor	NN
cord-017640-i8h48ny6	42	22	proteins	protein	NNS
cord-017640-i8h48ny6	42	23	for	for	IN
cord-017640-i8h48ny6	42	24	signaling	signal	VBG
cord-017640-i8h48ny6	42	25	.	.	.
cord-017640-i8h48ny6	43	1	Among	among	IN
cord-017640-i8h48ny6	43	2	these	these	DT
cord-017640-i8h48ny6	43	3	adaptor	adaptor	NN
cord-017640-i8h48ny6	43	4	proteins	protein	NNS
cord-017640-i8h48ny6	43	5	,	,	,
cord-017640-i8h48ny6	43	6	TRADD	TRADD	NNP
cord-017640-i8h48ny6	43	7	or	or	CC
cord-017640-i8h48ny6	43	8	FADD	FADD	NNP
cord-017640-i8h48ny6	43	9	is	be	VBZ
cord-017640-i8h48ny6	43	10	instrumental	instrumental	JJ
cord-017640-i8h48ny6	43	11	in	in	IN
cord-017640-i8h48ny6	43	12	the	the	DT
cord-017640-i8h48ny6	43	13	implementation	implementation	NN
cord-017640-i8h48ny6	43	14	of	of	IN
cord-017640-i8h48ny6	43	15	cell	cell	NN
cord-017640-i8h48ny6	43	16	death	death	NN
cord-017640-i8h48ny6	43	17	processes	process	NNS
cord-017640-i8h48ny6	43	18	[	[	-LRB-
cord-017640-i8h48ny6	43	19	7	7	CD
cord-017640-i8h48ny6	43	20	]	]	-RRB-
cord-017640-i8h48ny6	43	21	[	[	-LRB-
cord-017640-i8h48ny6	43	22	8	8	CD
cord-017640-i8h48ny6	43	23	]	]	-RRB-
cord-017640-i8h48ny6	43	24	[	[	-LRB-
cord-017640-i8h48ny6	43	25	9	9	CD
cord-017640-i8h48ny6	43	26	]	]	-RRB-
cord-017640-i8h48ny6	43	27	[	[	-LRB-
cord-017640-i8h48ny6	43	28	10	10	CD
cord-017640-i8h48ny6	43	29	]	]	-RRB-
cord-017640-i8h48ny6	43	30	.	.	.
cord-017640-i8h48ny6	44	1	TNF	TNF	NNP
cord-017640-i8h48ny6	44	2	is	be	VBZ
cord-017640-i8h48ny6	44	3	synthesized	synthesize	VBN
cord-017640-i8h48ny6	44	4	as	as	IN
cord-017640-i8h48ny6	44	5	a	a	DT
cord-017640-i8h48ny6	44	6	26	26	CD
cord-017640-i8h48ny6	44	7	kDa	kDa	NNP
cord-017640-i8h48ny6	44	8	transmembrane	transmembrane	NNP
cord-017640-i8h48ny6	44	9	type	type	NN
cord-017640-i8h48ny6	44	10	II	II	NNP
cord-017640-i8h48ny6	44	11	protein	protein	NN
cord-017640-i8h48ny6	44	12	(	(	-LRB-
cord-017640-i8h48ny6	44	13	m	m	NNP
cord-017640-i8h48ny6	44	14	-	-	HYPH
cord-017640-i8h48ny6	44	15	TNF	TNF	NNP
cord-017640-i8h48ny6	44	16	)	)	-RRB-
cord-017640-i8h48ny6	44	17	of	of	IN
cord-017640-i8h48ny6	44	18	233	233	CD
cord-017640-i8h48ny6	44	19	amino	amino	JJ
cord-017640-i8h48ny6	44	20	acids	acid	NNS
cord-017640-i8h48ny6	44	21	[	[	-LRB-
cord-017640-i8h48ny6	44	22	30	30	CD
cord-017640-i8h48ny6	44	23	]	]	-RRB-
cord-017640-i8h48ny6	44	24	which	which	WDT
cord-017640-i8h48ny6	44	25	can	can	MD
cord-017640-i8h48ny6	44	26	be	be	VB
cord-017640-i8h48ny6	44	27	cleaved	cleave	VBN
cord-017640-i8h48ny6	44	28	by	by	IN
cord-017640-i8h48ny6	44	29	the	the	DT
cord-017640-i8h48ny6	44	30	metalloprotease	metalloprotease	NNP
cord-017640-i8h48ny6	44	31	TACE	TACE	NNP
cord-017640-i8h48ny6	44	32	[	[	-LRB-
cord-017640-i8h48ny6	44	33	31	31	CD
cord-017640-i8h48ny6	44	34	,	,	,
cord-017640-i8h48ny6	44	35	32	32	CD
cord-017640-i8h48ny6	44	36	]	]	-RRB-
cord-017640-i8h48ny6	44	37	to	to	TO
cord-017640-i8h48ny6	44	38	release	release	VB
cord-017640-i8h48ny6	44	39	the	the	DT
cord-017640-i8h48ny6	44	40	17	17	CD
cord-017640-i8h48ny6	44	41	kDa	kDa	NNP
cord-017640-i8h48ny6	44	42	soluble	soluble	JJ
cord-017640-i8h48ny6	44	43	form	form	NN
cord-017640-i8h48ny6	44	44	of	of	IN
cord-017640-i8h48ny6	44	45	the	the	DT
cord-017640-i8h48ny6	44	46	cytokine	cytokine	NN
cord-017640-i8h48ny6	44	47	(	(	-LRB-
cord-017640-i8h48ny6	44	48	cl	cl	NNP
cord-017640-i8h48ny6	44	49	-	-	HYPH
cord-017640-i8h48ny6	44	50	TNF	TNF	NNP
cord-017640-i8h48ny6	44	51	)	)	-RRB-
cord-017640-i8h48ny6	44	52	.	.	.
cord-017640-i8h48ny6	45	1	In	in	IN
cord-017640-i8h48ny6	45	2	contrast	contrast	NN
cord-017640-i8h48ny6	45	3	to	to	IN
cord-017640-i8h48ny6	45	4	cl	cl	NNP
cord-017640-i8h48ny6	45	5	-	-	HYPH
cord-017640-i8h48ny6	45	6	TNF	TNF	NNP
cord-017640-i8h48ny6	45	7	,	,	,
cord-017640-i8h48ny6	45	8	which	which	WDT
cord-017640-i8h48ny6	45	9	only	only	RB
cord-017640-i8h48ny6	45	10	activates	activate	VBZ
cord-017640-i8h48ny6	45	11	TNFR1	tnfr1	XX
cord-017640-i8h48ny6	45	12	,	,	,
cord-017640-i8h48ny6	45	13	m	m	NNP
cord-017640-i8h48ny6	45	14	-	-	HYPH
cord-017640-i8h48ny6	45	15	TNF	TNF	NNP
cord-017640-i8h48ny6	45	16	can	can	MD
cord-017640-i8h48ny6	45	17	bind	bind	VB
cord-017640-i8h48ny6	45	18	and	and	CC
cord-017640-i8h48ny6	45	19	activate	activate	VB
cord-017640-i8h48ny6	45	20	both	both	DT
cord-017640-i8h48ny6	45	21	TNFR1	tnfr1	XX
cord-017640-i8h48ny6	46	1	and	and	CC
cord-017640-i8h48ny6	46	2	TNFR2	TNFR2	NNP
cord-017640-i8h48ny6	46	3	[	[	-LRB-
cord-017640-i8h48ny6	46	4	33	33	CD
cord-017640-i8h48ny6	46	5	]	]	-RRB-
cord-017640-i8h48ny6	46	6	.	.	.
cord-017640-i8h48ny6	47	1	Activation	activation	NN
cord-017640-i8h48ny6	47	2	of	of	IN
cord-017640-i8h48ny6	47	3	TNFR1	TNFR1	NNP
cord-017640-i8h48ny6	47	4	leads	lead	VBZ
cord-017640-i8h48ny6	47	5	to	to	IN
cord-017640-i8h48ny6	47	6	the	the	DT
cord-017640-i8h48ny6	47	7	induction	induction	NN
cord-017640-i8h48ny6	47	8	of	of	IN
cord-017640-i8h48ny6	47	9	cellular	cellular	JJ
cord-017640-i8h48ny6	47	10	processes	process	NNS
cord-017640-i8h48ny6	47	11	ranging	range	VBG
cord-017640-i8h48ny6	47	12	from	from	IN
cord-017640-i8h48ny6	47	13	cell	cell	NN
cord-017640-i8h48ny6	47	14	death	death	NN
cord-017640-i8h48ny6	47	15	(	(	-LRB-
cord-017640-i8h48ny6	47	16	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	47	17	or	or	CC
cord-017640-i8h48ny6	47	18	necroptosis	necroptosis	NN
cord-017640-i8h48ny6	47	19	)	)	-RRB-
cord-017640-i8h48ny6	47	20	to	to	IN
cord-017640-i8h48ny6	47	21	cell	cell	NN
cord-017640-i8h48ny6	47	22	proliferation	proliferation	NN
cord-017640-i8h48ny6	47	23	,	,	,
cord-017640-i8h48ny6	47	24	migration	migration	NN
cord-017640-i8h48ny6	47	25	,	,	,
cord-017640-i8h48ny6	47	26	and	and	CC
cord-017640-i8h48ny6	47	27	differentiation	differentiation	NN
cord-017640-i8h48ny6	47	28	;	;	:
cord-017640-i8h48ny6	47	29	the	the	DT
cord-017640-i8h48ny6	47	30	implementation	implementation	NN
cord-017640-i8h48ny6	47	31	of	of	IN
cord-017640-i8h48ny6	47	32	such	such	JJ
cord-017640-i8h48ny6	47	33	different	different	JJ
cord-017640-i8h48ny6	47	34	cellular	cellular	JJ
cord-017640-i8h48ny6	47	35	responses	response	NNS
cord-017640-i8h48ny6	47	36	reflects	reflect	VBZ
cord-017640-i8h48ny6	47	37	the	the	DT
cord-017640-i8h48ny6	47	38	formation	formation	NN
cord-017640-i8h48ny6	47	39	of	of	IN
cord-017640-i8h48ny6	47	40	different	different	JJ
cord-017640-i8h48ny6	47	41	molecular	molecular	JJ
cord-017640-i8h48ny6	47	42	complexes	complex	NNS
cord-017640-i8h48ny6	47	43	after	after	IN
cord-017640-i8h48ny6	47	44	receptor	receptor	NN
cord-017640-i8h48ny6	47	45	activation	activation	NN
cord-017640-i8h48ny6	47	46	[	[	-LRB-
cord-017640-i8h48ny6	47	47	28	28	CD
cord-017640-i8h48ny6	47	48	]	]	-RRB-
cord-017640-i8h48ny6	47	49	.	.	.
cord-017640-i8h48ny6	48	1	Binding	Binding	NNP
cord-017640-i8h48ny6	48	2	of	of	IN
cord-017640-i8h48ny6	48	3	TNF	TNF	NNP
cord-017640-i8h48ny6	48	4	to	to	IN
cord-017640-i8h48ny6	48	5	TNFR1	TNFR1	NNP
cord-017640-i8h48ny6	48	6	causes	cause	VBZ
cord-017640-i8h48ny6	48	7	the	the	DT
cord-017640-i8h48ny6	48	8	formation	formation	NN
cord-017640-i8h48ny6	48	9	of	of	IN
cord-017640-i8h48ny6	48	10	two	two	CD
cord-017640-i8h48ny6	48	11	consecutive	consecutive	JJ
cord-017640-i8h48ny6	48	12	complexes	complex	NNS
cord-017640-i8h48ny6	48	13	.	.	.
cord-017640-i8h48ny6	49	1	While	while	IN
cord-017640-i8h48ny6	49	2	the	the	DT
cord-017640-i8h48ny6	49	3	plasma	plasma	NN
cord-017640-i8h48ny6	49	4	membrane	membrane	NN
cord-017640-i8h48ny6	49	5	complex	complex	NN
cord-017640-i8h48ny6	49	6	(	(	-LRB-
cord-017640-i8h48ny6	49	7	complex	complex	JJ
cord-017640-i8h48ny6	49	8	I	i	NN
cord-017640-i8h48ny6	49	9	)	)	-RRB-
cord-017640-i8h48ny6	49	10	elicits	elicit	VBZ
cord-017640-i8h48ny6	49	11	a	a	DT
cord-017640-i8h48ny6	49	12	non	non	JJ
cord-017640-i8h48ny6	49	13	-	-	JJ
cord-017640-i8h48ny6	49	14	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	49	15	signaling	signal	VBG
cord-017640-i8h48ny6	49	16	pathway	pathway	NN
cord-017640-i8h48ny6	49	17	,	,	,
cord-017640-i8h48ny6	49	18	a	a	DT
cord-017640-i8h48ny6	49	19	second	second	JJ
cord-017640-i8h48ny6	49	20	,	,	,
cord-017640-i8h48ny6	49	21	internalized	internalize	VBN
cord-017640-i8h48ny6	49	22	complex	complex	NN
cord-017640-i8h48ny6	49	23	(	(	-LRB-
cord-017640-i8h48ny6	49	24	complex	complex	JJ
cord-017640-i8h48ny6	49	25	II	ii	CD
cord-017640-i8h48ny6	49	26	or	or	CC
cord-017640-i8h48ny6	49	27	DISC	DISC	NNP
cord-017640-i8h48ny6	49	28	)	)	-RRB-
cord-017640-i8h48ny6	49	29	triggers	trigger	VBZ
cord-017640-i8h48ny6	49	30	cell	cell	NN
cord-017640-i8h48ny6	49	31	death	death	NN
cord-017640-i8h48ny6	49	32	[	[	-LRB-
cord-017640-i8h48ny6	49	33	2	2	CD
cord-017640-i8h48ny6	49	34	]	]	-RRB-
cord-017640-i8h48ny6	49	35	.	.	.
cord-017640-i8h48ny6	50	1	In	in	IN
cord-017640-i8h48ny6	50	2	the	the	DT
cord-017640-i8h48ny6	50	3	presence	presence	NN
cord-017640-i8h48ny6	50	4	of	of	IN
cord-017640-i8h48ny6	50	5	TNF	TNF	NNP
cord-017640-i8h48ny6	50	6	,	,	,
cord-017640-i8h48ny6	50	7	the	the	DT
cord-017640-i8h48ny6	50	8	adaptor	adaptor	NN
cord-017640-i8h48ny6	50	9	protein	protein	NN
cord-017640-i8h48ny6	50	10	TRADD	TRADD	NNP
cord-017640-i8h48ny6	50	11	interacts	interact	VBZ
cord-017640-i8h48ny6	50	12	with	with	IN
cord-017640-i8h48ny6	50	13	TNFR1	TNFR1	NNP
cord-017640-i8h48ny6	50	14	and	and	CC
cord-017640-i8h48ny6	50	15	recruits	recruit	VBZ
cord-017640-i8h48ny6	50	16	other	other	JJ
cord-017640-i8h48ny6	50	17	proteins	protein	NNS
cord-017640-i8h48ny6	50	18	involved	involve	VBN
cord-017640-i8h48ny6	50	19	in	in	IN
cord-017640-i8h48ny6	50	20	the	the	DT
cord-017640-i8h48ny6	50	21	signaling	signaling	NN
cord-017640-i8h48ny6	50	22	of	of	IN
cord-017640-i8h48ny6	50	23	the	the	DT
cord-017640-i8h48ny6	50	24	receptor	receptor	NN
cord-017640-i8h48ny6	50	25	,	,	,
cord-017640-i8h48ny6	50	26	such	such	JJ
cord-017640-i8h48ny6	50	27	as	as	IN
cord-017640-i8h48ny6	50	28	TRAF2	TRAF2	NNP
cord-017640-i8h48ny6	50	29	,	,	,
cord-017640-i8h48ny6	50	30	cIAP1	ciap1	NN
cord-017640-i8h48ny6	50	31	,	,	,
cord-017640-i8h48ny6	50	32	cIAP2	ciap2	UH
cord-017640-i8h48ny6	50	33	,	,	,
cord-017640-i8h48ny6	50	34	and	and	CC
cord-017640-i8h48ny6	50	35	RIP1	RIP1	NNP
cord-017640-i8h48ny6	50	36	,	,	,
cord-017640-i8h48ny6	50	37	to	to	TO
cord-017640-i8h48ny6	50	38	form	form	VB
cord-017640-i8h48ny6	50	39	complex	complex	JJ
cord-017640-i8h48ny6	50	40	I.	i.	NN
cord-017640-i8h48ny6	51	1	At	at	IN
cord-017640-i8h48ny6	51	2	the	the	DT
cord-017640-i8h48ny6	51	3	plasma	plasma	NN
cord-017640-i8h48ny6	51	4	membrane	membrane	NN
cord-017640-i8h48ny6	51	5	,	,	,
cord-017640-i8h48ny6	51	6	this	this	DT
cord-017640-i8h48ny6	51	7	complex	complex	NN
cord-017640-i8h48ny6	51	8	activates	activate	VBZ
cord-017640-i8h48ny6	51	9	the	the	DT
cord-017640-i8h48ny6	51	10	NF	nf	NN
cord-017640-i8h48ny6	51	11	-	-	HYPH
cord-017640-i8h48ny6	51	12	κB	κB	NNP
cord-017640-i8h48ny6	51	13	signaling	signal	VBG
cord-017640-i8h48ny6	51	14	pathway	pathway	NN
cord-017640-i8h48ny6	51	15	,	,	,
cord-017640-i8h48ny6	51	16	which	which	WDT
cord-017640-i8h48ny6	51	17	in	in	IN
cord-017640-i8h48ny6	51	18	turn	turn	NN
cord-017640-i8h48ny6	51	19	promotes	promote	VBZ
cord-017640-i8h48ny6	51	20	the	the	DT
cord-017640-i8h48ny6	51	21	transcription	transcription	NN
cord-017640-i8h48ny6	51	22	of	of	IN
cord-017640-i8h48ny6	51	23	antiapoptotic	antiapoptotic	JJ
cord-017640-i8h48ny6	51	24	genes	gene	NNS
cord-017640-i8h48ny6	51	25	such	such	JJ
cord-017640-i8h48ny6	51	26	as	as	IN
cord-017640-i8h48ny6	51	27	cIAP1	ciap1	NN
cord-017640-i8h48ny6	51	28	,	,	,
cord-017640-i8h48ny6	51	29	cIAP2	cIAP2	NNP
cord-017640-i8h48ny6	51	30	,	,	,
cord-017640-i8h48ny6	51	31	and	and	CC
cord-017640-i8h48ny6	51	32	c	c	LS
cord-017640-i8h48ny6	51	33	-	-	:
cord-017640-i8h48ny6	51	34	FLIP	FLIP	NNP
cord-017640-i8h48ny6	51	35	[	[	-LRB-
cord-017640-i8h48ny6	51	36	34	34	CD
cord-017640-i8h48ny6	51	37	]	]	-RRB-
cord-017640-i8h48ny6	51	38	.	.	.
cord-017640-i8h48ny6	52	1	The	the	DT
cord-017640-i8h48ny6	52	2	linear	linear	JJ
cord-017640-i8h48ny6	52	3	ubiquitin	ubiquitin	NN
cord-017640-i8h48ny6	52	4	chain	chain	NN
cord-017640-i8h48ny6	52	5	assembly	assembly	NN
cord-017640-i8h48ny6	52	6	complex	complex	NN
cord-017640-i8h48ny6	52	7	(	(	-LRB-
cord-017640-i8h48ny6	52	8	LUBAC	LUBAC	NNP
cord-017640-i8h48ny6	52	9	)	)	-RRB-
cord-017640-i8h48ny6	52	10	is	be	VBZ
cord-017640-i8h48ny6	52	11	also	also	RB
cord-017640-i8h48ny6	52	12	recruited	recruit	VBN
cord-017640-i8h48ny6	52	13	to	to	TO
cord-017640-i8h48ny6	52	14	complex	complex	VB
cord-017640-i8h48ny6	52	15	I	-PRON-	PRP
cord-017640-i8h48ny6	52	16	via	via	IN
cord-017640-i8h48ny6	52	17	cIAP	ciap	NN
cord-017640-i8h48ny6	52	18	-	-	HYPH
cord-017640-i8h48ny6	52	19	generated	generate	VBN
cord-017640-i8h48ny6	52	20	ubiquitin	ubiquitin	NN
cord-017640-i8h48ny6	52	21	chains	chain	NNS
cord-017640-i8h48ny6	52	22	[	[	-LRB-
cord-017640-i8h48ny6	52	23	35	35	CD
cord-017640-i8h48ny6	52	24	]	]	-RRB-
cord-017640-i8h48ny6	52	25	.	.	.
cord-017640-i8h48ny6	53	1	HOIL-1	HOIL-1	NNP
cord-017640-i8h48ny6	53	2	,	,	,
cord-017640-i8h48ny6	53	3	HOIP	HOIP	NNP
cord-017640-i8h48ny6	53	4	,	,	,
cord-017640-i8h48ny6	53	5	and	and	CC
cord-017640-i8h48ny6	53	6	sharpin	sharpin	NNP
cord-017640-i8h48ny6	53	7	constitute	constitute	VBP
cord-017640-i8h48ny6	53	8	the	the	DT
cord-017640-i8h48ny6	53	9	LUBAC	LUBAC	NNP
cord-017640-i8h48ny6	53	10	complex	complex	NN
cord-017640-i8h48ny6	53	11	.	.	.
cord-017640-i8h48ny6	54	1	HOIL-1	HOIL-1	NNP
cord-017640-i8h48ny6	54	2	and	and	CC
cord-017640-i8h48ny6	54	3	HOIP	HOIP	NNP
cord-017640-i8h48ny6	54	4	add	add	VBP
cord-017640-i8h48ny6	54	5	a	a	DT
cord-017640-i8h48ny6	54	6	linear	linear	JJ
cord-017640-i8h48ny6	54	7	ubiquitin	ubiquitin	NN
cord-017640-i8h48ny6	54	8	chain	chain	NN
cord-017640-i8h48ny6	54	9	by	by	IN
cord-017640-i8h48ny6	54	10	catalyzing	catalyze	VBG
cord-017640-i8h48ny6	54	11	the	the	DT
cord-017640-i8h48ny6	54	12	head	head	NN
cord-017640-i8h48ny6	54	13	-	-	HYPH
cord-017640-i8h48ny6	54	14	to	to	IN
cord-017640-i8h48ny6	54	15	-	-	HYPH
cord-017640-i8h48ny6	54	16	tail	tail	NN
cord-017640-i8h48ny6	54	17	ligation	ligation	NN
cord-017640-i8h48ny6	54	18	of	of	IN
cord-017640-i8h48ny6	54	19	ubiquitin	ubiquitin	NN
cord-017640-i8h48ny6	54	20	[	[	-LRB-
cord-017640-i8h48ny6	54	21	36	36	CD
cord-017640-i8h48ny6	54	22	]	]	-RRB-
cord-017640-i8h48ny6	54	23	to	to	IN
cord-017640-i8h48ny6	54	24	RIP1	RIP1	NNP
cord-017640-i8h48ny6	54	25	and	and	CC
cord-017640-i8h48ny6	54	26	NEMO	NEMO	NNP
cord-017640-i8h48ny6	54	27	(	(	-LRB-
cord-017640-i8h48ny6	54	28	IKK	IKK	NNP
cord-017640-i8h48ny6	54	29	-	-	HYPH
cord-017640-i8h48ny6	54	30	γ	γ	NNP
cord-017640-i8h48ny6	54	31	)	)	-RRB-
cord-017640-i8h48ny6	54	32	in	in	IN
cord-017640-i8h48ny6	54	33	complex	complex	NN
cord-017640-i8h48ny6	55	1	I	-PRON-	PRP
cord-017640-i8h48ny6	55	2	[	[	-LRB-
cord-017640-i8h48ny6	55	3	37	37	CD
cord-017640-i8h48ny6	55	4	]	]	-RRB-
cord-017640-i8h48ny6	55	5	,	,	,
cord-017640-i8h48ny6	55	6	thereby	thereby	RB
cord-017640-i8h48ny6	55	7	activating	activate	VBG
cord-017640-i8h48ny6	55	8	NF	nf	NN
cord-017640-i8h48ny6	55	9	-	-	HYPH
cord-017640-i8h48ny6	55	10	κB.	κb.	NN
cord-017640-i8h48ny6	55	11	TNF	TNF	NNP
cord-017640-i8h48ny6	55	12	-	-	HYPH
cord-017640-i8h48ny6	55	13	induced	induce	VBN
cord-017640-i8h48ny6	55	14	caspase	caspase	NN
cord-017640-i8h48ny6	55	15	activation	activation	NN
cord-017640-i8h48ny6	55	16	is	be	VBZ
cord-017640-i8h48ny6	55	17	mediated	mediate	VBN
cord-017640-i8h48ny6	55	18	by	by	IN
cord-017640-i8h48ny6	55	19	a	a	DT
cord-017640-i8h48ny6	55	20	second	second	JJ
cord-017640-i8h48ny6	55	21	,	,	,
cord-017640-i8h48ny6	55	22	intracellular	intracellular	JJ
cord-017640-i8h48ny6	55	23	complex	complex	JJ
cord-017640-i8h48ny6	55	24	II	II	NNP
cord-017640-i8h48ny6	55	25	,	,	,
cord-017640-i8h48ny6	55	26	which	which	WDT
cord-017640-i8h48ny6	55	27	is	be	VBZ
cord-017640-i8h48ny6	55	28	formed	form	VBN
cord-017640-i8h48ny6	55	29	when	when	WRB
cord-017640-i8h48ny6	55	30	complex	complex	JJ
cord-017640-i8h48ny6	55	31	I	-PRON-	PRP
cord-017640-i8h48ny6	55	32	dissociates	dissociate	VBZ
cord-017640-i8h48ny6	55	33	from	from	IN
cord-017640-i8h48ny6	55	34	the	the	DT
cord-017640-i8h48ny6	55	35	receptor	receptor	NN
cord-017640-i8h48ny6	55	36	,	,	,
cord-017640-i8h48ny6	55	37	along	along	IN
cord-017640-i8h48ny6	55	38	with	with	IN
cord-017640-i8h48ny6	55	39	FADD	FADD	NNP
cord-017640-i8h48ny6	55	40	and	and	CC
cord-017640-i8h48ny6	55	41	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	55	42	recruitment	recruitment	NN
cord-017640-i8h48ny6	55	43	[	[	-LRB-
cord-017640-i8h48ny6	55	44	2	2	CD
cord-017640-i8h48ny6	55	45	]	]	-RRB-
cord-017640-i8h48ny6	55	46	.	.	.
cord-017640-i8h48ny6	56	1	NF	NF	NNP
cord-017640-i8h48ny6	56	2	-	-	HYPH
cord-017640-i8h48ny6	56	3	κB	κb	CD
cord-017640-i8h48ny6	56	4	activation	activation	NN
cord-017640-i8h48ny6	56	5	leads	lead	VBZ
cord-017640-i8h48ny6	56	6	to	to	IN
cord-017640-i8h48ny6	56	7	c	c	NN
cord-017640-i8h48ny6	56	8	-	-	HYPH
cord-017640-i8h48ny6	56	9	FLIP	flip	NN
cord-017640-i8h48ny6	56	10	overexpression	overexpression	NN
cord-017640-i8h48ny6	56	11	,	,	,
cord-017640-i8h48ny6	56	12	preventing	prevent	VBG
cord-017640-i8h48ny6	56	13	formation	formation	NN
cord-017640-i8h48ny6	56	14	of	of	IN
cord-017640-i8h48ny6	56	15	complex	complex	JJ
cord-017640-i8h48ny6	56	16	II	ii	CD
cord-017640-i8h48ny6	56	17	.	.	.
cord-017640-i8h48ny6	57	1	Contrariwise	contrariwise	RB
cord-017640-i8h48ny6	57	2	,	,	,
cord-017640-i8h48ny6	57	3	when	when	WRB
cord-017640-i8h48ny6	57	4	NF	nf	NN
cord-017640-i8h48ny6	57	5	-	-	HYPH
cord-017640-i8h48ny6	57	6	κB	κb	CD
cord-017640-i8h48ny6	57	7	activation	activation	NN
cord-017640-i8h48ny6	57	8	is	be	VBZ
cord-017640-i8h48ny6	57	9	blocked	block	VBN
cord-017640-i8h48ny6	57	10	,	,	,
cord-017640-i8h48ny6	57	11	c	c	NN
cord-017640-i8h48ny6	57	12	-	-	:
cord-017640-i8h48ny6	57	13	FLIP	FLIP	NNP
cord-017640-i8h48ny6	57	14	,	,	,
cord-017640-i8h48ny6	58	1	whose	whose	WP$
cord-017640-i8h48ny6	58	2	protein	protein	NN
cord-017640-i8h48ny6	58	3	half	half	JJ
cord-017640-i8h48ny6	58	4	-	-	HYPH
cord-017640-i8h48ny6	58	5	life	life	NN
cord-017640-i8h48ny6	58	6	is	be	VBZ
cord-017640-i8h48ny6	58	7	short	short	JJ
cord-017640-i8h48ny6	58	8	[	[	-LRB-
cord-017640-i8h48ny6	58	9	38	38	CD
cord-017640-i8h48ny6	58	10	]	]	-RRB-
cord-017640-i8h48ny6	58	11	,	,	,
cord-017640-i8h48ny6	58	12	is	be	VBZ
cord-017640-i8h48ny6	58	13	absent	absent	JJ
cord-017640-i8h48ny6	58	14	,	,	,
cord-017640-i8h48ny6	58	15	and	and	CC
cord-017640-i8h48ny6	58	16	cells	cell	NNS
cord-017640-i8h48ny6	58	17	experience	experience	VBP
cord-017640-i8h48ny6	58	18	death	death	NN
cord-017640-i8h48ny6	58	19	[	[	-LRB-
cord-017640-i8h48ny6	58	20	2	2	CD
cord-017640-i8h48ny6	58	21	]	]	-RRB-
cord-017640-i8h48ny6	58	22	.	.	.
cord-017640-i8h48ny6	59	1	RIP1	RIP1	NNP
cord-017640-i8h48ny6	59	2	is	be	VBZ
cord-017640-i8h48ny6	59	3	deubiquitinated	deubiquitinate	VBN
cord-017640-i8h48ny6	59	4	by	by	IN
cord-017640-i8h48ny6	59	5	enzymes	enzyme	NNS
cord-017640-i8h48ny6	59	6	such	such	JJ
cord-017640-i8h48ny6	59	7	as	as	IN
cord-017640-i8h48ny6	59	8	Cezanne	Cezanne	NNP
cord-017640-i8h48ny6	59	9	[	[	-LRB-
cord-017640-i8h48ny6	59	10	39	39	CD
cord-017640-i8h48ny6	59	11	]	]	-RRB-
cord-017640-i8h48ny6	59	12	and	and	CC
cord-017640-i8h48ny6	59	13	CYLD	CYLD	NNP
cord-017640-i8h48ny6	59	14	[	[	-LRB-
cord-017640-i8h48ny6	59	15	40	40	CD
cord-017640-i8h48ny6	59	16	]	]	-RRB-
cord-017640-i8h48ny6	59	17	,	,	,
cord-017640-i8h48ny6	59	18	and	and	CC
cord-017640-i8h48ny6	59	19	the	the	DT
cord-017640-i8h48ny6	59	20	complex	complex	NN
cord-017640-i8h48ny6	59	21	composed	compose	VBN
cord-017640-i8h48ny6	59	22	of	of	IN
cord-017640-i8h48ny6	59	23	TRADD	TRADD	NNP
cord-017640-i8h48ny6	59	24	and	and	CC
cord-017640-i8h48ny6	59	25	RIP1	RIP1	NNP
cord-017640-i8h48ny6	59	26	moves	move	NNS
cord-017640-i8h48ny6	59	27	to	to	IN
cord-017640-i8h48ny6	59	28	the	the	DT
cord-017640-i8h48ny6	59	29	cytosol	cytosol	NN
cord-017640-i8h48ny6	59	30	to	to	TO
cord-017640-i8h48ny6	59	31	form	form	VB
cord-017640-i8h48ny6	59	32	complex	complex	JJ
cord-017640-i8h48ny6	59	33	II	II	NNP
cord-017640-i8h48ny6	59	34	.	.	.
cord-017640-i8h48ny6	60	1	FADD	FADD	NNP
cord-017640-i8h48ny6	60	2	is	be	VBZ
cord-017640-i8h48ny6	60	3	recruited	recruit	VBN
cord-017640-i8h48ny6	60	4	to	to	IN
cord-017640-i8h48ny6	60	5	TRADD	TRADD	NNP
cord-017640-i8h48ny6	60	6	by	by	IN
cord-017640-i8h48ny6	60	7	DD	DD	NNP
cord-017640-i8h48ny6	60	8	-	-	HYPH
cord-017640-i8h48ny6	60	9	DD	DD	NNP
cord-017640-i8h48ny6	60	10	interaction	interaction	NN
cord-017640-i8h48ny6	60	11	and	and	CC
cord-017640-i8h48ny6	60	12	binds	bind	VBZ
cord-017640-i8h48ny6	60	13	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	60	14	[	[	-LRB-
cord-017640-i8h48ny6	60	15	2	2	CD
cord-017640-i8h48ny6	60	16	]	]	-RRB-
cord-017640-i8h48ny6	60	17	.	.	.
cord-017640-i8h48ny6	61	1	Noteworthy	noteworthy	JJ
cord-017640-i8h48ny6	61	2	,	,	,
cord-017640-i8h48ny6	61	3	when	when	WRB
cord-017640-i8h48ny6	61	4	caspase-8	caspase-8	JJ
cord-017640-i8h48ny6	61	5	activity	activity	NN
cord-017640-i8h48ny6	61	6	is	be	VBZ
cord-017640-i8h48ny6	61	7	inhibited	inhibit	VBN
cord-017640-i8h48ny6	61	8	or	or	CC
cord-017640-i8h48ny6	61	9	its	-PRON-	PRP$
cord-017640-i8h48ny6	61	10	expression	expression	NN
cord-017640-i8h48ny6	61	11	is	be	VBZ
cord-017640-i8h48ny6	61	12	extinguished	extinguish	VBN
cord-017640-i8h48ny6	61	13	,	,	,
cord-017640-i8h48ny6	61	14	DISC	DISC	NNP
cord-017640-i8h48ny6	61	15	is	be	VBZ
cord-017640-i8h48ny6	61	16	unable	unable	JJ
cord-017640-i8h48ny6	61	17	to	to	TO
cord-017640-i8h48ny6	61	18	trigger	trigger	VB
cord-017640-i8h48ny6	61	19	the	the	DT
cord-017640-i8h48ny6	61	20	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	61	21	signaling	signal	VBG
cord-017640-i8h48ny6	61	22	pathway	pathway	NN
cord-017640-i8h48ny6	61	23	;	;	:
cord-017640-i8h48ny6	61	24	but	but	CC
cord-017640-i8h48ny6	61	25	TNFR1	TNFR1	NNP
cord-017640-i8h48ny6	61	26	or	or	CC
cord-017640-i8h48ny6	61	27	CD95	CD95	NNP
cord-017640-i8h48ny6	61	28	stimulation	stimulation	NN
cord-017640-i8h48ny6	61	29	leads	lead	VBZ
cord-017640-i8h48ny6	61	30	to	to	IN
cord-017640-i8h48ny6	61	31	the	the	DT
cord-017640-i8h48ny6	61	32	activation	activation	NN
cord-017640-i8h48ny6	61	33	of	of	IN
cord-017640-i8h48ny6	61	34	another	another	DT
cord-017640-i8h48ny6	61	35	cell	cell	NN
cord-017640-i8h48ny6	61	36	death	death	NN
cord-017640-i8h48ny6	61	37	signal	signal	NN
cord-017640-i8h48ny6	61	38	,	,	,
cord-017640-i8h48ny6	61	39	namely	namely	RB
cord-017640-i8h48ny6	61	40	,	,	,
cord-017640-i8h48ny6	61	41	necroptosis	necroptosis	NNP
cord-017640-i8h48ny6	61	42	[	[	-LRB-
cord-017640-i8h48ny6	61	43	41	41	CD
cord-017640-i8h48ny6	61	44	,	,	,
cord-017640-i8h48ny6	61	45	42	42	CD
cord-017640-i8h48ny6	61	46	]	]	-RRB-
cord-017640-i8h48ny6	61	47	.	.	.
cord-017640-i8h48ny6	62	1	To	to	TO
cord-017640-i8h48ny6	62	2	prevent	prevent	VB
cord-017640-i8h48ny6	62	3	the	the	DT
cord-017640-i8h48ny6	62	4	induction	induction	NN
cord-017640-i8h48ny6	62	5	of	of	IN
cord-017640-i8h48ny6	62	6	the	the	DT
cord-017640-i8h48ny6	62	7	necroptotic	necroptotic	JJ
cord-017640-i8h48ny6	62	8	signal	signal	NN
cord-017640-i8h48ny6	62	9	,	,	,
cord-017640-i8h48ny6	62	10	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	62	11	cleaves	cleave	VBZ
cord-017640-i8h48ny6	62	12	and	and	CC
cord-017640-i8h48ny6	62	13	inactivates	inactivate	VBZ
cord-017640-i8h48ny6	62	14	RIP1	RIP1	NNP
cord-017640-i8h48ny6	62	15	and	and	CC
cord-017640-i8h48ny6	62	16	RIP3	RIP3	NNPS
cord-017640-i8h48ny6	62	17	[	[	-LRB-
cord-017640-i8h48ny6	62	18	43	43	CD
cord-017640-i8h48ny6	62	19	]	]	-RRB-
cord-017640-i8h48ny6	62	20	.	.	.
cord-017640-i8h48ny6	63	1	The	the	DT
cord-017640-i8h48ny6	63	2	fine	fine	RB
cord-017640-i8h48ny6	63	3	-	-	HYPH
cord-017640-i8h48ny6	63	4	tuned	tune	VBN
cord-017640-i8h48ny6	63	5	control	control	NN
cord-017640-i8h48ny6	63	6	of	of	IN
cord-017640-i8h48ny6	63	7	necroptosis	necroptosis	NNP
cord-017640-i8h48ny6	63	8	by	by	IN
cord-017640-i8h48ny6	63	9	members	member	NNS
cord-017640-i8h48ny6	63	10	of	of	IN
cord-017640-i8h48ny6	63	11	the	the	DT
cord-017640-i8h48ny6	63	12	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	63	13	signaling	signal	VBG
cord-017640-i8h48ny6	63	14	pathway	pathway	NN
cord-017640-i8h48ny6	63	15	in	in	IN
cord-017640-i8h48ny6	63	16	the	the	DT
cord-017640-i8h48ny6	63	17	organism	organism	NN
cord-017640-i8h48ny6	63	18	has	have	VBZ
cord-017640-i8h48ny6	63	19	been	be	VBN
cord-017640-i8h48ny6	63	20	elegantly	elegantly	RB
cord-017640-i8h48ny6	63	21	confirmed	confirm	VBN
cord-017640-i8h48ny6	63	22	by	by	IN
cord-017640-i8h48ny6	63	23	experiments	experiment	NNS
cord-017640-i8h48ny6	63	24	showing	show	VBG
cord-017640-i8h48ny6	63	25	that	that	IN
cord-017640-i8h48ny6	63	26	the	the	DT
cord-017640-i8h48ny6	63	27	embryonic	embryonic	JJ
cord-017640-i8h48ny6	63	28	lethality	lethality	NN
cord-017640-i8h48ny6	63	29	of	of	IN
cord-017640-i8h48ny6	63	30	mice	mouse	NNS
cord-017640-i8h48ny6	63	31	harboring	harbor	VBG
cord-017640-i8h48ny6	63	32	the	the	DT
cord-017640-i8h48ny6	63	33	single	single	JJ
cord-017640-i8h48ny6	63	34	KO	KO	NNP
cord-017640-i8h48ny6	63	35	of	of	IN
cord-017640-i8h48ny6	63	36	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	63	37	or	or	CC
cord-017640-i8h48ny6	63	38	FADD	FADD	NNP
cord-017640-i8h48ny6	63	39	is	be	VBZ
cord-017640-i8h48ny6	63	40	rescued	rescue	VBN
cord-017640-i8h48ny6	63	41	by	by	IN
cord-017640-i8h48ny6	63	42	an	an	DT
cord-017640-i8h48ny6	63	43	additional	additional	JJ
cord-017640-i8h48ny6	63	44	KO	ko	NN
cord-017640-i8h48ny6	63	45	of	of	IN
cord-017640-i8h48ny6	63	46	the	the	DT
cord-017640-i8h48ny6	63	47	RIP3	RIP3	NNP
cord-017640-i8h48ny6	63	48	gene	gene	NN
cord-017640-i8h48ny6	63	49	[	[	-LRB-
cord-017640-i8h48ny6	63	50	44	44	CD
cord-017640-i8h48ny6	63	51	]	]	-RRB-
cord-017640-i8h48ny6	63	52	[	[	-LRB-
cord-017640-i8h48ny6	63	53	45	45	CD
cord-017640-i8h48ny6	63	54	]	]	-RRB-
cord-017640-i8h48ny6	63	55	[	[	-LRB-
cord-017640-i8h48ny6	63	56	46	46	CD
cord-017640-i8h48ny6	63	57	]	]	-RRB-
cord-017640-i8h48ny6	63	58	.	.	.
cord-017640-i8h48ny6	64	1	Many	many	JJ
cord-017640-i8h48ny6	64	2	studies	study	NNS
cord-017640-i8h48ny6	64	3	on	on	IN
cord-017640-i8h48ny6	64	4	TNF	TNF	NNP
cord-017640-i8h48ny6	64	5	demonstrated	demonstrate	VBD
cord-017640-i8h48ny6	64	6	its	-PRON-	PRP$
cord-017640-i8h48ny6	64	7	pivotal	pivotal	JJ
cord-017640-i8h48ny6	64	8	role	role	NN
cord-017640-i8h48ny6	64	9	in	in	IN
cord-017640-i8h48ny6	64	10	fueling	fuel	VBG
cord-017640-i8h48ny6	64	11	inflammation	inflammation	NN
cord-017640-i8h48ny6	64	12	,	,	,
cord-017640-i8h48ny6	64	13	a	a	DT
cord-017640-i8h48ny6	64	14	multistep	multistep	JJ
cord-017640-i8h48ny6	64	15	process	process	NN
cord-017640-i8h48ny6	64	16	that	that	WDT
cord-017640-i8h48ny6	64	17	promotes	promote	VBZ
cord-017640-i8h48ny6	64	18	autoimmunity	autoimmunity	NN
cord-017640-i8h48ny6	64	19	(	(	-LRB-
cord-017640-i8h48ny6	64	20	e.g.	e.g.	RB
cord-017640-i8h48ny6	64	21	,	,	,
cord-017640-i8h48ny6	64	22	rheumatoid	rheumatoid	NN
cord-017640-i8h48ny6	64	23	arthritis	arthritis	NN
cord-017640-i8h48ny6	64	24	,	,	,
cord-017640-i8h48ny6	64	25	ankylosing	ankylosing	NN
cord-017640-i8h48ny6	64	26	spondylitis	spondylitis	NN
cord-017640-i8h48ny6	64	27	,	,	,
cord-017640-i8h48ny6	64	28	Crohn	Crohn	NNP
cord-017640-i8h48ny6	64	29	's	's	POS
cord-017640-i8h48ny6	64	30	disease	disease	NN
cord-017640-i8h48ny6	64	31	,	,	,
cord-017640-i8h48ny6	64	32	psoriasis	psoriasis	NN
cord-017640-i8h48ny6	64	33	,	,	,
cord-017640-i8h48ny6	64	34	and	and	CC
cord-017640-i8h48ny6	64	35	refractory	refractory	JJ
cord-017640-i8h48ny6	64	36	asthma	asthma	NN
cord-017640-i8h48ny6	64	37	)	)	-RRB-
cord-017640-i8h48ny6	64	38	and	and	CC
cord-017640-i8h48ny6	64	39	cancer	cancer	NN
cord-017640-i8h48ny6	64	40	.	.	.
cord-017640-i8h48ny6	65	1	Many	many	JJ
cord-017640-i8h48ny6	65	2	TNF	TNF	NNP
cord-017640-i8h48ny6	65	3	inhibitors	inhibitor	NNS
cord-017640-i8h48ny6	65	4	,	,	,
cord-017640-i8h48ny6	65	5	such	such	JJ
cord-017640-i8h48ny6	65	6	as	as	IN
cord-017640-i8h48ny6	65	7	neutralizing	neutralize	VBG
cord-017640-i8h48ny6	65	8	monoclonal	monoclonal	JJ
cord-017640-i8h48ny6	65	9	antibodies	antibody	NNS
cord-017640-i8h48ny6	65	10	(	(	-LRB-
cord-017640-i8h48ny6	65	11	mAbs	mabs	NN
cord-017640-i8h48ny6	65	12	)	)	-RRB-
cord-017640-i8h48ny6	65	13	(	(	-LRB-
cord-017640-i8h48ny6	65	14	e.g.	e.g.	RB
cord-017640-i8h48ny6	65	15	,	,	,
cord-017640-i8h48ny6	65	16	infliximab	infliximab	NNP
cord-017640-i8h48ny6	65	17	,	,	,
cord-017640-i8h48ny6	65	18	adalimumab	adalimumab	NNS
cord-017640-i8h48ny6	65	19	,	,	,
cord-017640-i8h48ny6	65	20	and	and	CC
cord-017640-i8h48ny6	65	21	golimumab	golimumab	NNP
cord-017640-i8h48ny6	65	22	)	)	-RRB-
cord-017640-i8h48ny6	65	23	,	,	,
cord-017640-i8h48ny6	65	24	have	have	VBP
cord-017640-i8h48ny6	65	25	been	be	VBN
cord-017640-i8h48ny6	65	26	developed	develop	VBN
cord-017640-i8h48ny6	65	27	to	to	TO
cord-017640-i8h48ny6	65	28	treat	treat	VB
cord-017640-i8h48ny6	65	29	these	these	DT
cord-017640-i8h48ny6	65	30	chronic	chronic	JJ
cord-017640-i8h48ny6	65	31	inflammatory	inflammatory	JJ
cord-017640-i8h48ny6	65	32	disorders	disorder	NNS
cord-017640-i8h48ny6	65	33	,	,	,
cord-017640-i8h48ny6	65	34	demonstrating	demonstrate	VBG
cord-017640-i8h48ny6	65	35	that	that	IN
cord-017640-i8h48ny6	65	36	altering	alter	VBG
cord-017640-i8h48ny6	65	37	ligand	ligand	NN
cord-017640-i8h48ny6	65	38	/	/	SYM
cord-017640-i8h48ny6	65	39	receptor	receptor	NN
cord-017640-i8h48ny6	65	40	interactions	interaction	NNS
cord-017640-i8h48ny6	65	41	with	with	IN
cord-017640-i8h48ny6	65	42	neutralizing	neutralize	VBG
cord-017640-i8h48ny6	65	43	mAbs	mAbs	NNP
cord-017640-i8h48ny6	65	44	is	be	VBZ
cord-017640-i8h48ny6	65	45	an	an	DT
cord-017640-i8h48ny6	65	46	invaluable	invaluable	JJ
cord-017640-i8h48ny6	65	47	opportunity	opportunity	NN
cord-017640-i8h48ny6	65	48	to	to	TO
cord-017640-i8h48ny6	65	49	treat	treat	VB
cord-017640-i8h48ny6	65	50	certain	certain	JJ
cord-017640-i8h48ny6	65	51	chronic	chronic	JJ
cord-017640-i8h48ny6	65	52	inflammatory	inflammatory	JJ
cord-017640-i8h48ny6	65	53	disorders	disorder	NNS
cord-017640-i8h48ny6	65	54	.	.	.
cord-017640-i8h48ny6	66	1	Other	other	JJ
cord-017640-i8h48ny6	66	2	TNF	TNF	NNP
cord-017640-i8h48ny6	66	3	-	-	HYPH
cord-017640-i8h48ny6	66	4	α	α	NNP
cord-017640-i8h48ny6	66	5	antagonists	antagonist	NNS
cord-017640-i8h48ny6	66	6	,	,	,
cord-017640-i8h48ny6	66	7	such	such	JJ
cord-017640-i8h48ny6	66	8	as	as	IN
cord-017640-i8h48ny6	66	9	etanercept	etanercept	NNP
cord-017640-i8h48ny6	66	10	,	,	,
cord-017640-i8h48ny6	66	11	a	a	DT
cord-017640-i8h48ny6	66	12	TNFR2-immunoglobulin	TNFR2-immunoglobulin	NNP
cord-017640-i8h48ny6	66	13	Fc	Fc	NNP
cord-017640-i8h48ny6	66	14	fusion	fusion	NN
cord-017640-i8h48ny6	66	15	protein	protein	NN
cord-017640-i8h48ny6	66	16	,	,	,
cord-017640-i8h48ny6	66	17	can	can	MD
cord-017640-i8h48ny6	66	18	improve	improve	VB
cord-017640-i8h48ny6	66	19	the	the	DT
cord-017640-i8h48ny6	66	20	clinical	clinical	JJ
cord-017640-i8h48ny6	66	21	course	course	NN
cord-017640-i8h48ny6	66	22	of	of	IN
cord-017640-i8h48ny6	66	23	rheumatoid	rheumatoid	NN
cord-017640-i8h48ny6	66	24	arthritis	arthritis	NN
cord-017640-i8h48ny6	66	25	[	[	-LRB-
cord-017640-i8h48ny6	66	26	47	47	CD
cord-017640-i8h48ny6	66	27	]	]	-RRB-
cord-017640-i8h48ny6	66	28	.	.	.
cord-017640-i8h48ny6	67	1	While	while	IN
cord-017640-i8h48ny6	67	2	findings	finding	NNS
cord-017640-i8h48ny6	67	3	accumulate	accumulate	VBP
cord-017640-i8h48ny6	67	4	to	to	TO
cord-017640-i8h48ny6	67	5	decipher	decipher	VB
cord-017640-i8h48ny6	67	6	the	the	DT
cord-017640-i8h48ny6	67	7	molecular	molecular	JJ
cord-017640-i8h48ny6	67	8	mechanisms	mechanism	NNS
cord-017640-i8h48ny6	67	9	involved	involve	VBN
cord-017640-i8h48ny6	67	10	in	in	IN
cord-017640-i8h48ny6	67	11	the	the	DT
cord-017640-i8h48ny6	67	12	induction	induction	NN
cord-017640-i8h48ny6	67	13	of	of	IN
cord-017640-i8h48ny6	67	14	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	67	15	and	and	CC
cord-017640-i8h48ny6	67	16	non	non	JJ
cord-017640-i8h48ny6	67	17	-	-	JJ
cord-017640-i8h48ny6	67	18	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	67	19	signaling	signal	VBG
cord-017640-i8h48ny6	67	20	pathways	pathway	NNS
cord-017640-i8h48ny6	67	21	by	by	IN
cord-017640-i8h48ny6	67	22	TNFR1	tnfr1	XX
cord-017640-i8h48ny6	67	23	and	and	CC
cord-017640-i8h48ny6	67	24	to	to	TO
cord-017640-i8h48ny6	67	25	elucidate	elucidate	VB
cord-017640-i8h48ny6	67	26	how	how	WRB
cord-017640-i8h48ny6	67	27	the	the	DT
cord-017640-i8h48ny6	67	28	receptor	receptor	NN
cord-017640-i8h48ny6	67	29	can	can	MD
cord-017640-i8h48ny6	67	30	switch	switch	VB
cord-017640-i8h48ny6	67	31	from	from	IN
cord-017640-i8h48ny6	67	32	one	one	CD
cord-017640-i8h48ny6	67	33	signal	signal	NN
cord-017640-i8h48ny6	67	34	to	to	IN
cord-017640-i8h48ny6	67	35	the	the	DT
cord-017640-i8h48ny6	67	36	other	other	JJ
cord-017640-i8h48ny6	67	37	,	,	,
cord-017640-i8h48ny6	67	38	the	the	DT
cord-017640-i8h48ny6	67	39	mechanistic	mechanistic	JJ
cord-017640-i8h48ny6	67	40	links	link	NNS
cord-017640-i8h48ny6	67	41	involved	involve	VBN
cord-017640-i8h48ny6	67	42	in	in	IN
cord-017640-i8h48ny6	67	43	the	the	DT
cord-017640-i8h48ny6	67	44	implementation	implementation	NN
cord-017640-i8h48ny6	67	45	of	of	IN
cord-017640-i8h48ny6	67	46	non	non	JJ
cord-017640-i8h48ny6	67	47	-	-	JJ
cord-017640-i8h48ny6	67	48	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	67	49	signaling	signal	VBG
cord-017640-i8h48ny6	67	50	pathways	pathway	NNS
cord-017640-i8h48ny6	67	51	by	by	IN
cord-017640-i8h48ny6	67	52	CD95	CD95	NNP
cord-017640-i8h48ny6	67	53	remain	remain	VBP
cord-017640-i8h48ny6	67	54	elusive	elusive	JJ
cord-017640-i8h48ny6	67	55	.	.	.
cord-017640-i8h48ny6	68	1	However	however	RB
cord-017640-i8h48ny6	68	2	,	,	,
cord-017640-i8h48ny6	68	3	recent	recent	JJ
cord-017640-i8h48ny6	68	4	findings	finding	NNS
cord-017640-i8h48ny6	68	5	have	have	VBP
cord-017640-i8h48ny6	68	6	revealed	reveal	VBN
cord-017640-i8h48ny6	68	7	its	-PRON-	PRP$
cord-017640-i8h48ny6	68	8	proinflammatory	proinflammatory	JJ
cord-017640-i8h48ny6	68	9	effects	effect	NNS
cord-017640-i8h48ny6	68	10	[	[	-LRB-
cord-017640-i8h48ny6	68	11	48	48	CD
cord-017640-i8h48ny6	68	12	]	]	-RRB-
cord-017640-i8h48ny6	68	13	[	[	-LRB-
cord-017640-i8h48ny6	68	14	49	49	CD
cord-017640-i8h48ny6	68	15	]	]	-RRB-
cord-017640-i8h48ny6	68	16	[	[	-LRB-
cord-017640-i8h48ny6	68	17	50	50	CD
cord-017640-i8h48ny6	68	18	]	]	-RRB-
cord-017640-i8h48ny6	68	19	[	[	-LRB-
cord-017640-i8h48ny6	68	20	51	51	CD
cord-017640-i8h48ny6	68	21	]	]	-RRB-
cord-017640-i8h48ny6	68	22	[	[	-LRB-
cord-017640-i8h48ny6	68	23	52	52	CD
cord-017640-i8h48ny6	68	24	]	]	-RRB-
cord-017640-i8h48ny6	68	25	[	[	-LRB-
cord-017640-i8h48ny6	68	26	53	53	CD
cord-017640-i8h48ny6	68	27	]	]	-RRB-
cord-017640-i8h48ny6	68	28	[	[	-LRB-
cord-017640-i8h48ny6	68	29	54	54	CD
cord-017640-i8h48ny6	68	30	]	]	-RRB-
cord-017640-i8h48ny6	68	31	.	.	.
cord-017640-i8h48ny6	69	1	In	in	IN
cord-017640-i8h48ny6	69	2	1989	1989	CD
cord-017640-i8h48ny6	69	3	,	,	,
cord-017640-i8h48ny6	69	4	identification	identification	NN
cord-017640-i8h48ny6	69	5	of	of	IN
cord-017640-i8h48ny6	69	6	the	the	DT
cord-017640-i8h48ny6	69	7	mAb	mAb	NNP
cord-017640-i8h48ny6	69	8	APO-1	APO-1	NNP
cord-017640-i8h48ny6	69	9	by	by	IN
cord-017640-i8h48ny6	69	10	Peter	Peter	NNP
cord-017640-i8h48ny6	69	11	Krammer	Krammer	NNP
cord-017640-i8h48ny6	69	12	et	et	NNP
cord-017640-i8h48ny6	69	13	al	al	NNP
cord-017640-i8h48ny6	69	14	.	.	NNP
cord-017640-i8h48ny6	69	15	revealed	reveal	VBD
cord-017640-i8h48ny6	69	16	the	the	DT
cord-017640-i8h48ny6	69	17	existence	existence	NN
cord-017640-i8h48ny6	69	18	of	of	IN
cord-017640-i8h48ny6	69	19	a	a	DT
cord-017640-i8h48ny6	69	20	52	52	CD
cord-017640-i8h48ny6	69	21	kDa	kDa	NNP
cord-017640-i8h48ny6	69	22	protein	protein	NN
cord-017640-i8h48ny6	69	23	whose	whose	WP$
cord-017640-i8h48ny6	69	24	aggregation	aggregation	NN
cord-017640-i8h48ny6	69	25	was	be	VBD
cord-017640-i8h48ny6	69	26	able	able	JJ
cord-017640-i8h48ny6	69	27	to	to	TO
cord-017640-i8h48ny6	69	28	transmit	transmit	VB
cord-017640-i8h48ny6	69	29	an	an	DT
cord-017640-i8h48ny6	69	30	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	69	31	signal	signal	NN
cord-017640-i8h48ny6	69	32	in	in	IN
cord-017640-i8h48ny6	69	33	cancer	cancer	NN
cord-017640-i8h48ny6	69	34	cells	cell	NNS
cord-017640-i8h48ny6	69	35	[	[	-LRB-
cord-017640-i8h48ny6	69	36	55	55	CD
cord-017640-i8h48ny6	69	37	]	]	-RRB-
cord-017640-i8h48ny6	69	38	.	.	.
cord-017640-i8h48ny6	70	1	This	this	DT
cord-017640-i8h48ny6	70	2	receptor	receptor	NN
cord-017640-i8h48ny6	70	3	was	be	VBD
cord-017640-i8h48ny6	70	4	identified	identify	VBN
cord-017640-i8h48ny6	70	5	in	in	IN
cord-017640-i8h48ny6	70	6	1991	1991	CD
cord-017640-i8h48ny6	70	7	by	by	IN
cord-017640-i8h48ny6	70	8	Nagata	Nagata	NNP
cord-017640-i8h48ny6	70	9	and	and	CC
cord-017640-i8h48ny6	70	10	colleagues	colleague	NNS
cord-017640-i8h48ny6	70	11	and	and	CC
cord-017640-i8h48ny6	70	12	called	call	VBN
cord-017640-i8h48ny6	70	13	Fas	Fas	NNP
cord-017640-i8h48ny6	70	14	(	(	-LRB-
cord-017640-i8h48ny6	70	15	CD95	CD95	NNP
cord-017640-i8h48ny6	70	16	or	or	CC
cord-017640-i8h48ny6	70	17	APO-1	APO-1	NNP
cord-017640-i8h48ny6	70	18	)	)	-RRB-
cord-017640-i8h48ny6	71	1	[	[	-LRB-
cord-017640-i8h48ny6	71	2	12	12	CD
cord-017640-i8h48ny6	71	3	]	]	-RRB-
cord-017640-i8h48ny6	71	4	.	.	.
cord-017640-i8h48ny6	72	1	Its	-PRON-	PRP$
cord-017640-i8h48ny6	72	2	ligand	ligand	NN
cord-017640-i8h48ny6	72	3	,	,	,
cord-017640-i8h48ny6	72	4	FasL	FasL	NNP
cord-017640-i8h48ny6	72	5	,	,	,
cord-017640-i8h48ny6	72	6	was	be	VBD
cord-017640-i8h48ny6	72	7	cloned	clone	VBN
cord-017640-i8h48ny6	72	8	in	in	IN
cord-017640-i8h48ny6	72	9	1993	1993	CD
cord-017640-i8h48ny6	72	10	by	by	IN
cord-017640-i8h48ny6	72	11	the	the	DT
cord-017640-i8h48ny6	72	12	same	same	JJ
cord-017640-i8h48ny6	72	13	group	group	NN
cord-017640-i8h48ny6	72	14	and	and	CC
cord-017640-i8h48ny6	72	15	was	be	VBD
cord-017640-i8h48ny6	72	16	found	find	VBN
cord-017640-i8h48ny6	72	17	to	to	TO
cord-017640-i8h48ny6	72	18	be	be	VB
cord-017640-i8h48ny6	72	19	mainly	mainly	RB
cord-017640-i8h48ny6	72	20	expressed	express	VBN
cord-017640-i8h48ny6	72	21	at	at	IN
cord-017640-i8h48ny6	72	22	the	the	DT
cord-017640-i8h48ny6	72	23	surface	surface	NN
cord-017640-i8h48ny6	72	24	of	of	IN
cord-017640-i8h48ny6	72	25	activated	activate	VBN
cord-017640-i8h48ny6	72	26	T	t	NN
cord-017640-i8h48ny6	72	27	-	-	HYPH
cord-017640-i8h48ny6	72	28	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	72	29	[	[	-LRB-
cord-017640-i8h48ny6	72	30	56	56	CD
cord-017640-i8h48ny6	72	31	]	]	-RRB-
cord-017640-i8h48ny6	72	32	and	and	CC
cord-017640-i8h48ny6	72	33	natural	natural	JJ
cord-017640-i8h48ny6	72	34	killer	killer	NN
cord-017640-i8h48ny6	72	35	(	(	-LRB-
cord-017640-i8h48ny6	72	36	NK	NK	NNP
cord-017640-i8h48ny6	72	37	)	)	-RRB-
cord-017640-i8h48ny6	72	38	cells	cell	NNS
cord-017640-i8h48ny6	72	39	[	[	-LRB-
cord-017640-i8h48ny6	72	40	57	57	CD
cord-017640-i8h48ny6	72	41	]	]	-RRB-
cord-017640-i8h48ny6	72	42	;	;	:
cord-017640-i8h48ny6	72	43	however	however	RB
cord-017640-i8h48ny6	72	44	,	,	,
cord-017640-i8h48ny6	72	45	its	-PRON-	PRP$
cord-017640-i8h48ny6	72	46	expression	expression	NN
cord-017640-i8h48ny6	72	47	was	be	VBD
cord-017640-i8h48ny6	72	48	also	also	RB
cord-017640-i8h48ny6	72	49	detected	detect	VBN
cord-017640-i8h48ny6	72	50	in	in	IN
cord-017640-i8h48ny6	72	51	different	different	JJ
cord-017640-i8h48ny6	72	52	tissues	tissue	NNS
cord-017640-i8h48ny6	72	53	in	in	IN
cord-017640-i8h48ny6	72	54	which	which	WDT
cord-017640-i8h48ny6	72	55	the	the	DT
cord-017640-i8h48ny6	72	56	presence	presence	NN
cord-017640-i8h48ny6	72	57	of	of	IN
cord-017640-i8h48ny6	72	58	acute	acute	JJ
cord-017640-i8h48ny6	72	59	or	or	CC
cord-017640-i8h48ny6	72	60	chronic	chronic	JJ
cord-017640-i8h48ny6	72	61	inflammation	inflammation	NN
cord-017640-i8h48ny6	72	62	is	be	VBZ
cord-017640-i8h48ny6	72	63	undesirable	undesirable	JJ
cord-017640-i8h48ny6	72	64	including	include	VBG
cord-017640-i8h48ny6	72	65	the	the	DT
cord-017640-i8h48ny6	72	66	eyes	eye	NNS
cord-017640-i8h48ny6	72	67	[	[	-LRB-
cord-017640-i8h48ny6	72	68	58	58	CD
cord-017640-i8h48ny6	72	69	]	]	-RRB-
cord-017640-i8h48ny6	72	70	and	and	CC
cord-017640-i8h48ny6	72	71	testes	testis	NNS
cord-017640-i8h48ny6	72	72	[	[	-LRB-
cord-017640-i8h48ny6	72	73	59	59	CD
cord-017640-i8h48ny6	72	74	]	]	-RRB-
cord-017640-i8h48ny6	72	75	.	.	.
cord-017640-i8h48ny6	73	1	In	in	IN
cord-017640-i8h48ny6	73	2	addition	addition	NN
cord-017640-i8h48ny6	73	3	,	,	,
cord-017640-i8h48ny6	73	4	two	two	CD
cord-017640-i8h48ny6	73	5	mouse	mouse	NN
cord-017640-i8h48ny6	73	6	models	model	NNS
cord-017640-i8h48ny6	73	7	,	,	,
cord-017640-i8h48ny6	73	8	in	in	IN
cord-017640-i8h48ny6	73	9	which	which	WDT
cord-017640-i8h48ny6	73	10	either	either	CC
cord-017640-i8h48ny6	73	11	the	the	DT
cord-017640-i8h48ny6	73	12	level	level	NN
cord-017640-i8h48ny6	73	13	of	of	IN
cord-017640-i8h48ny6	73	14	CD95	CD95	NNP
cord-017640-i8h48ny6	73	15	expression	expression	NN
cord-017640-i8h48ny6	73	16	was	be	VBD
cord-017640-i8h48ny6	73	17	downregulated	downregulate	VBN
cord-017640-i8h48ny6	73	18	(	(	-LRB-
cord-017640-i8h48ny6	73	19	due	due	IN
cord-017640-i8h48ny6	73	20	to	to	IN
cord-017640-i8h48ny6	73	21	an	an	DT
cord-017640-i8h48ny6	73	22	insertion	insertion	NN
cord-017640-i8h48ny6	73	23	of	of	IN
cord-017640-i8h48ny6	73	24	a	a	DT
cord-017640-i8h48ny6	73	25	retrotransposon	retrotransposon	NN
cord-017640-i8h48ny6	73	26	in	in	IN
cord-017640-i8h48ny6	73	27	intron	intron	NN
cord-017640-i8h48ny6	73	28	2	2	CD
cord-017640-i8h48ny6	73	29	of	of	IN
cord-017640-i8h48ny6	73	30	the	the	DT
cord-017640-i8h48ny6	73	31	receptor	receptor	NN
cord-017640-i8h48ny6	73	32	gene	gene	NN
cord-017640-i8h48ny6	73	33	,	,	,
cord-017640-i8h48ny6	73	34	these	these	DT
cord-017640-i8h48ny6	73	35	mice	mouse	NNS
cord-017640-i8h48ny6	73	36	are	be	VBP
cord-017640-i8h48ny6	73	37	called	call	VBN
cord-017640-i8h48ny6	73	38	lymphoproliferation	lymphoproliferation	NN
cord-017640-i8h48ny6	74	1	(	(	-LRB-
cord-017640-i8h48ny6	74	2	Lpr	Lpr	NNP
cord-017640-i8h48ny6	74	3	)	)	-RRB-
cord-017640-i8h48ny6	75	1	[	[	-LRB-
cord-017640-i8h48ny6	75	2	60	60	CD
cord-017640-i8h48ny6	75	3	]	]	-RRB-
cord-017640-i8h48ny6	75	4	[	[	-LRB-
cord-017640-i8h48ny6	75	5	61	61	CD
cord-017640-i8h48ny6	75	6	]	]	-RRB-
cord-017640-i8h48ny6	76	1	[	[	-LRB-
cord-017640-i8h48ny6	76	2	62	62	CD
cord-017640-i8h48ny6	76	3	]	]	-RRB-
cord-017640-i8h48ny6	76	4	)	)	-RRB-
cord-017640-i8h48ny6	77	1	or	or	CC
cord-017640-i8h48ny6	77	2	the	the	DT
cord-017640-i8h48ny6	77	3	CD95L	cd95l	NN
cord-017640-i8h48ny6	77	4	affinity	affinity	NN
cord-017640-i8h48ny6	77	5	for	for	IN
cord-017640-i8h48ny6	77	6	CD95	CD95	NNP
cord-017640-i8h48ny6	77	7	was	be	VBD
cord-017640-i8h48ny6	77	8	reduced	reduce	VBN
cord-017640-i8h48ny6	77	9	(	(	-LRB-
cord-017640-i8h48ny6	77	10	due	due	IN
cord-017640-i8h48ny6	77	11	to	to	IN
cord-017640-i8h48ny6	77	12	the	the	DT
cord-017640-i8h48ny6	77	13	germ	germ	NN
cord-017640-i8h48ny6	77	14	line	line	NN
cord-017640-i8h48ny6	77	15	mutation	mutation	NN
cord-017640-i8h48ny6	77	16	F273L	F273L	NNP
cord-017640-i8h48ny6	77	17	in	in	IN
cord-017640-i8h48ny6	77	18	CD95L	cd95l	NN
cord-017640-i8h48ny6	77	19	,	,	,
cord-017640-i8h48ny6	77	20	called	call	VBD
cord-017640-i8h48ny6	77	21	generalized	generalize	VBN
cord-017640-i8h48ny6	77	22	lymphoproliferative	lymphoproliferative	JJ
cord-017640-i8h48ny6	77	23	disease	disease	NNP
cord-017640-i8h48ny6	77	24	(	(	-LRB-
cord-017640-i8h48ny6	77	25	gld	gld	NNP
cord-017640-i8h48ny6	77	26	)	)	-RRB-
cord-017640-i8h48ny6	77	27	,	,	,
cord-017640-i8h48ny6	77	28	which	which	WDT
cord-017640-i8h48ny6	77	29	decreases	decrease	VBZ
cord-017640-i8h48ny6	77	30	CD95L	cd95l	NN
cord-017640-i8h48ny6	77	31	binding	bind	VBG
cord-017640-i8h48ny6	77	32	to	to	IN
cord-017640-i8h48ny6	77	33	CD95	CD95	NNP
cord-017640-i8h48ny6	77	34	[	[	-LRB-
cord-017640-i8h48ny6	77	35	63	63	CD
cord-017640-i8h48ny6	77	36	,	,	,
cord-017640-i8h48ny6	77	37	64	64	CD
cord-017640-i8h48ny6	77	38	]	]	-RRB-
cord-017640-i8h48ny6	77	39	)	)	-RRB-
cord-017640-i8h48ny6	77	40	,	,	,
cord-017640-i8h48ny6	77	41	have	have	VBP
cord-017640-i8h48ny6	77	42	provided	provide	VBN
cord-017640-i8h48ny6	77	43	some	some	DT
cord-017640-i8h48ny6	77	44	insight	insight	NN
cord-017640-i8h48ny6	77	45	into	into	IN
cord-017640-i8h48ny6	77	46	the	the	DT
cord-017640-i8h48ny6	77	47	pivotal	pivotal	JJ
cord-017640-i8h48ny6	77	48	role	role	NN
cord-017640-i8h48ny6	77	49	played	play	VBN
cord-017640-i8h48ny6	77	50	by	by	IN
cord-017640-i8h48ny6	77	51	this	this	DT
cord-017640-i8h48ny6	77	52	interaction	interaction	NN
cord-017640-i8h48ny6	77	53	in	in	IN
cord-017640-i8h48ny6	77	54	immunosurveillance	immunosurveillance	NN
cord-017640-i8h48ny6	77	55	and	and	CC
cord-017640-i8h48ny6	77	56	immune	immune	JJ
cord-017640-i8h48ny6	77	57	tolerance	tolerance	NN
cord-017640-i8h48ny6	77	58	[	[	-LRB-
cord-017640-i8h48ny6	77	59	65	65	CD
cord-017640-i8h48ny6	77	60	]	]	-RRB-
cord-017640-i8h48ny6	77	61	.	.	.
cord-017640-i8h48ny6	78	1	The	the	DT
cord-017640-i8h48ny6	78	2	CD95	CD95	NNP
cord-017640-i8h48ny6	78	3	gene	gene	NN
cord-017640-i8h48ny6	78	4	(	(	-LRB-
cord-017640-i8h48ny6	78	5	APT-1	APT-1	NNP
cord-017640-i8h48ny6	78	6	)	)	-RRB-
cord-017640-i8h48ny6	78	7	consists	consist	VBZ
cord-017640-i8h48ny6	78	8	of	of	IN
cord-017640-i8h48ny6	78	9	nine	nine	CD
cord-017640-i8h48ny6	78	10	exons	exon	NNS
cord-017640-i8h48ny6	78	11	,	,	,
cord-017640-i8h48ny6	78	12	with	with	IN
cord-017640-i8h48ny6	78	13	exon	exon	NN
cord-017640-i8h48ny6	78	14	6	6	CD
cord-017640-i8h48ny6	78	15	encoding	encode	VBG
cord-017640-i8h48ny6	78	16	the	the	DT
cord-017640-i8h48ny6	78	17	transmembrane	transmembrane	NN
cord-017640-i8h48ny6	78	18	domain	domain	NN
cord-017640-i8h48ny6	78	19	[	[	-LRB-
cord-017640-i8h48ny6	78	20	66	66	CD
cord-017640-i8h48ny6	78	21	]	]	-RRB-
cord-017640-i8h48ny6	79	1	(	(	-LRB-
cord-017640-i8h48ny6	79	2	Fig	Fig	NNP
cord-017640-i8h48ny6	79	3	.	.	.
cord-017640-i8h48ny6	79	4	11.1	11.1	CD
cord-017640-i8h48ny6	79	5	)	)	-RRB-
cord-017640-i8h48ny6	79	6	.	.	.
cord-017640-i8h48ny6	80	1	CD95	CD95	NNP
cord-017640-i8h48ny6	80	2	can	can	MD
cord-017640-i8h48ny6	80	3	be	be	VB
cord-017640-i8h48ny6	80	4	resolved	resolve	VBN
cord-017640-i8h48ny6	80	5	under	under	IN
cord-017640-i8h48ny6	80	6	denaturing	denaturing	JJ
cord-017640-i8h48ny6	80	7	conditions	condition	NNS
cord-017640-i8h48ny6	80	8	between	between	IN
cord-017640-i8h48ny6	80	9	40	40	CD
cord-017640-i8h48ny6	80	10	and	and	CC
cord-017640-i8h48ny6	80	11	50	50	CD
cord-017640-i8h48ny6	80	12	kDa	kDa	NNS
cord-017640-i8h48ny6	80	13	by	by	IN
cord-017640-i8h48ny6	80	14	SDS	SDS	NNP
cord-017640-i8h48ny6	80	15	-	-	HYPH
cord-017640-i8h48ny6	80	16	PAGE	PAGE	NNP
cord-017640-i8h48ny6	80	17	.	.	.
cord-017640-i8h48ny6	81	1	The	the	DT
cord-017640-i8h48ny6	81	2	receptor	receptor	NN
cord-017640-i8h48ny6	81	3	is	be	VBZ
cord-017640-i8h48ny6	81	4	a	a	DT
cord-017640-i8h48ny6	81	5	type	type	NN
cord-017640-i8h48ny6	81	6	I	-PRON-	PRP
cord-017640-i8h48ny6	81	7	transmembrane	transmembrane	NN
cord-017640-i8h48ny6	81	8	protein	protein	NN
cord-017640-i8h48ny6	81	9	harboring	harbor	VBG
cord-017640-i8h48ny6	81	10	three	three	CD
cord-017640-i8h48ny6	81	11	CRDs	crd	NNS
cord-017640-i8h48ny6	81	12	.	.	.
cord-017640-i8h48ny6	82	1	Similar	similar	JJ
cord-017640-i8h48ny6	82	2	to	to	IN
cord-017640-i8h48ny6	82	3	the	the	DT
cord-017640-i8h48ny6	82	4	TNF	TNF	NNP
cord-017640-i8h48ny6	82	5	receptor	receptor	NN
cord-017640-i8h48ny6	82	6	[	[	-LRB-
cord-017640-i8h48ny6	82	7	29	29	CD
cord-017640-i8h48ny6	82	8	]	]	-RRB-
cord-017640-i8h48ny6	82	9	,	,	,
cord-017640-i8h48ny6	82	10	CD95	CD95	NNP
cord-017640-i8h48ny6	82	11	is	be	VBZ
cord-017640-i8h48ny6	82	12	pre	pre	JJ
cord-017640-i8h48ny6	82	13	-	-	JJ
cord-017640-i8h48ny6	82	14	associated	associate	VBN
cord-017640-i8h48ny6	82	15	at	at	IN
cord-017640-i8h48ny6	82	16	the	the	DT
cord-017640-i8h48ny6	82	17	plasma	plasma	NN
cord-017640-i8h48ny6	82	18	membrane	membrane	NN
cord-017640-i8h48ny6	82	19	as	as	IN
cord-017640-i8h48ny6	82	20	a	a	DT
cord-017640-i8h48ny6	82	21	homotrimer	homotrimer	NN
cord-017640-i8h48ny6	82	22	,	,	,
cord-017640-i8h48ny6	82	23	and	and	CC
cord-017640-i8h48ny6	82	24	this	this	DT
cord-017640-i8h48ny6	82	25	quaternary	quaternary	JJ
cord-017640-i8h48ny6	82	26	structure	structure	NN
cord-017640-i8h48ny6	82	27	is	be	VBZ
cord-017640-i8h48ny6	82	28	mandatory	mandatory	JJ
cord-017640-i8h48ny6	82	29	for	for	IN
cord-017640-i8h48ny6	82	30	transmission	transmission	NN
cord-017640-i8h48ny6	82	31	of	of	IN
cord-017640-i8h48ny6	82	32	the	the	DT
cord-017640-i8h48ny6	82	33	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	82	34	signals	signal	NNS
cord-017640-i8h48ny6	82	35	in	in	IN
cord-017640-i8h48ny6	82	36	the	the	DT
cord-017640-i8h48ny6	82	37	presence	presence	NN
cord-017640-i8h48ny6	82	38	of	of	IN
cord-017640-i8h48ny6	82	39	CD95L	CD95L	NNP
cord-017640-i8h48ny6	82	40	[	[	-LRB-
cord-017640-i8h48ny6	82	41	23	23	CD
cord-017640-i8h48ny6	82	42	,	,	,
cord-017640-i8h48ny6	82	43	24	24	CD
cord-017640-i8h48ny6	82	44	]	]	-RRB-
cord-017640-i8h48ny6	82	45	.	.	.
cord-017640-i8h48ny6	83	1	Homotrimerization	Homotrimerization	NNP
cord-017640-i8h48ny6	83	2	of	of	IN
cord-017640-i8h48ny6	83	3	CD95	CD95	NNP
cord-017640-i8h48ny6	83	4	occurs	occur	VBZ
cord-017640-i8h48ny6	83	5	mainly	mainly	RB
cord-017640-i8h48ny6	83	6	through	through	IN
cord-017640-i8h48ny6	83	7	homotypic	homotypic	JJ
cord-017640-i8h48ny6	83	8	interactions	interaction	NNS
cord-017640-i8h48ny6	83	9	of	of	IN
cord-017640-i8h48ny6	83	10	the	the	DT
cord-017640-i8h48ny6	83	11	CD95-CRD1	CD95-CRD1	NNP
cord-017640-i8h48ny6	83	12	[	[	-LRB-
cord-017640-i8h48ny6	83	13	22	22	CD
cord-017640-i8h48ny6	83	14	]	]	-RRB-
cord-017640-i8h48ny6	84	1	[	[	-LRB-
cord-017640-i8h48ny6	84	2	23	23	CD
cord-017640-i8h48ny6	84	3	]	]	-RRB-
cord-017640-i8h48ny6	84	4	[	[	-LRB-
cord-017640-i8h48ny6	84	5	24	24	CD
cord-017640-i8h48ny6	84	6	]	]	-RRB-
cord-017640-i8h48ny6	84	7	.	.	.
cord-017640-i8h48ny6	85	1	Binding	bind	VBG
cord-017640-i8h48ny6	85	2	of	of	IN
cord-017640-i8h48ny6	85	3	CD95L	cd95l	NN
cord-017640-i8h48ny6	85	4	or	or	CC
cord-017640-i8h48ny6	85	5	agonistic	agonistic	JJ
cord-017640-i8h48ny6	85	6	anti	anti	JJ
cord-017640-i8h48ny6	85	7	-	-	NNP
cord-017640-i8h48ny6	85	8	CD95	CD95	NNP
cord-017640-i8h48ny6	85	9	mAbs	mabs	NN
cord-017640-i8h48ny6	85	10	to	to	IN
cord-017640-i8h48ny6	85	11	CD95	CD95	NNP
cord-017640-i8h48ny6	85	12	alters	alter	VBZ
cord-017640-i8h48ny6	85	13	both	both	PDT
cord-017640-i8h48ny6	85	14	the	the	DT
cord-017640-i8h48ny6	85	15	conformation	conformation	NN
cord-017640-i8h48ny6	85	16	and	and	CC
cord-017640-i8h48ny6	85	17	the	the	DT
cord-017640-i8h48ny6	85	18	extent	extent	NN
cord-017640-i8h48ny6	85	19	to	to	TO
cord-017640-i8h48ny6	85	20	which	which	WDT
cord-017640-i8h48ny6	85	21	the	the	DT
cord-017640-i8h48ny6	85	22	receptor	receptor	NN
cord-017640-i8h48ny6	85	23	is	be	VBZ
cord-017640-i8h48ny6	85	24	multimerized	multimerize	VBN
cord-017640-i8h48ny6	85	25	at	at	IN
cord-017640-i8h48ny6	85	26	the	the	DT
cord-017640-i8h48ny6	85	27	plasma	plasma	NN
cord-017640-i8h48ny6	85	28	membrane	membrane	NN
cord-017640-i8h48ny6	85	29	.	.	.
cord-017640-i8h48ny6	86	1	The	the	DT
cord-017640-i8h48ny6	86	2	intracellular	intracellular	JJ
cord-017640-i8h48ny6	86	3	region	region	NN
cord-017640-i8h48ny6	86	4	of	of	IN
cord-017640-i8h48ny6	86	5	CD95	CD95	NNP
cord-017640-i8h48ny6	86	6	encompasses	encompass	VBZ
cord-017640-i8h48ny6	86	7	an	an	DT
cord-017640-i8h48ny6	86	8	80-amino	80-amino	CD
cord-017640-i8h48ny6	86	9	acid	acid	NN
cord-017640-i8h48ny6	86	10	stretch	stretch	NN
cord-017640-i8h48ny6	86	11	designated	designate	VBN
cord-017640-i8h48ny6	86	12	as	as	IN
cord-017640-i8h48ny6	86	13	the	the	DT
cord-017640-i8h48ny6	86	14	DD	DD	NNP
cord-017640-i8h48ny6	86	15	(	(	-LRB-
cord-017640-i8h48ny6	86	16	Fig	fig	NN
cord-017640-i8h48ny6	86	17	.	.	.
cord-017640-i8h48ny6	86	18	11	11	CD
cord-017640-i8h48ny6	86	19	.1	.1	CD
cord-017640-i8h48ny6	86	20	)	)	-RRB-
cord-017640-i8h48ny6	86	21	,	,	,
cord-017640-i8h48ny6	86	22	which	which	WDT
cord-017640-i8h48ny6	86	23	consists	consist	VBZ
cord-017640-i8h48ny6	86	24	of	of	IN
cord-017640-i8h48ny6	86	25	six	six	CD
cord-017640-i8h48ny6	86	26	antiparallel	antiparallel	NN
cord-017640-i8h48ny6	86	27	α	α	NN
cord-017640-i8h48ny6	86	28	-	-	HYPH
cord-017640-i8h48ny6	86	29	helices	helix	NNS
cord-017640-i8h48ny6	86	30	[	[	-LRB-
cord-017640-i8h48ny6	86	31	67	67	CD
cord-017640-i8h48ny6	86	32	]	]	-RRB-
cord-017640-i8h48ny6	86	33	.	.	.
cord-017640-i8h48ny6	87	1	Upon	upon	IN
cord-017640-i8h48ny6	87	2	addition	addition	NN
cord-017640-i8h48ny6	87	3	of	of	IN
cord-017640-i8h48ny6	87	4	CD95L	cd95l	NN
cord-017640-i8h48ny6	87	5	,	,	,
cord-017640-i8h48ny6	87	6	CD95	CD95	NNP
cord-017640-i8h48ny6	87	7	undergoes	undergo	VBZ
cord-017640-i8h48ny6	87	8	conformational	conformational	JJ
cord-017640-i8h48ny6	87	9	modification	modification	NN
cord-017640-i8h48ny6	87	10	of	of	IN
cord-017640-i8h48ny6	87	11	its	-PRON-	PRP$
cord-017640-i8h48ny6	87	12	DD	dd	NN
cord-017640-i8h48ny6	87	13	,	,	,
cord-017640-i8h48ny6	87	14	which	which	WDT
cord-017640-i8h48ny6	87	15	induces	induce	VBZ
cord-017640-i8h48ny6	87	16	a	a	DT
cord-017640-i8h48ny6	87	17	shift	shift	NN
cord-017640-i8h48ny6	87	18	of	of	IN
cord-017640-i8h48ny6	87	19	helix	helix	NN
cord-017640-i8h48ny6	87	20	6	6	CD
cord-017640-i8h48ny6	87	21	and	and	CC
cord-017640-i8h48ny6	87	22	fusion	fusion	NN
cord-017640-i8h48ny6	87	23	with	with	IN
cord-017640-i8h48ny6	87	24	helix	helix	NN
cord-017640-i8h48ny6	87	25	5	5	CD
cord-017640-i8h48ny6	87	26	,	,	,
cord-017640-i8h48ny6	87	27	promoting	promote	VBG
cord-017640-i8h48ny6	87	28	both	both	DT
cord-017640-i8h48ny6	87	29	oligomerization	oligomerization	NN
cord-017640-i8h48ny6	87	30	of	of	IN
cord-017640-i8h48ny6	87	31	the	the	DT
cord-017640-i8h48ny6	87	32	receptor	receptor	NN
cord-017640-i8h48ny6	87	33	and	and	CC
cord-017640-i8h48ny6	87	34	recruitment	recruitment	NN
cord-017640-i8h48ny6	87	35	of	of	IN
cord-017640-i8h48ny6	87	36	the	the	DT
cord-017640-i8h48ny6	87	37	adaptor	adaptor	NN
cord-017640-i8h48ny6	87	38	protein	protein	NN
cord-017640-i8h48ny6	87	39	FADD	FADD	NNP
cord-017640-i8h48ny6	87	40	[	[	-LRB-
cord-017640-i8h48ny6	87	41	68	68	CD
cord-017640-i8h48ny6	87	42	]	]	-RRB-
cord-017640-i8h48ny6	87	43	.	.	.
cord-017640-i8h48ny6	88	1	A	a	DT
cord-017640-i8h48ny6	88	2	consequence	consequence	NN
cord-017640-i8h48ny6	88	3	of	of	IN
cord-017640-i8h48ny6	88	4	the	the	DT
cord-017640-i8h48ny6	88	5	opening	opening	NN
cord-017640-i8h48ny6	88	6	of	of	IN
cord-017640-i8h48ny6	88	7	the	the	DT
cord-017640-i8h48ny6	88	8	globular	globular	JJ
cord-017640-i8h48ny6	88	9	structure	structure	NN
cord-017640-i8h48ny6	88	10	of	of	IN
cord-017640-i8h48ny6	88	11	CD95	CD95	NNP
cord-017640-i8h48ny6	88	12	is	be	VBZ
cord-017640-i8h48ny6	88	13	that	that	IN
cord-017640-i8h48ny6	88	14	the	the	DT
cord-017640-i8h48ny6	88	15	receptor	receptor	NN
cord-017640-i8h48ny6	88	16	becomes	become	VBZ
cord-017640-i8h48ny6	88	17	connected	connect	VBN
cord-017640-i8h48ny6	88	18	through	through	IN
cord-017640-i8h48ny6	88	19	this	this	DT
cord-017640-i8h48ny6	88	20	bridge	bridge	NN
cord-017640-i8h48ny6	88	21	,	,	,
cord-017640-i8h48ny6	88	22	which	which	WDT
cord-017640-i8h48ny6	88	23	increases	increase	VBZ
cord-017640-i8h48ny6	88	24	the	the	DT
cord-017640-i8h48ny6	88	25	magnitude	magnitude	NN
cord-017640-i8h48ny6	88	26	of	of	IN
cord-017640-i8h48ny6	88	27	its	-PRON-	PRP$
cord-017640-i8h48ny6	88	28	homo	homo	NN
cord-017640-i8h48ny6	88	29	-	-	HYPH
cord-017640-i8h48ny6	88	30	aggregation	aggregation	NN
cord-017640-i8h48ny6	88	31	.	.	.
cord-017640-i8h48ny6	89	1	This	this	DT
cord-017640-i8h48ny6	89	2	long	long	JJ
cord-017640-i8h48ny6	89	3	helix	helix	NN
cord-017640-i8h48ny6	89	4	allows	allow	VBZ
cord-017640-i8h48ny6	89	5	the	the	DT
cord-017640-i8h48ny6	89	6	stabilization	stabilization	NN
cord-017640-i8h48ny6	89	7	of	of	IN
cord-017640-i8h48ny6	89	8	the	the	DT
cord-017640-i8h48ny6	89	9	complex	complex	NN
cord-017640-i8h48ny6	89	10	by	by	IN
cord-017640-i8h48ny6	89	11	recruiting	recruit	VBG
cord-017640-i8h48ny6	89	12	FADD	FADD	NNP
cord-017640-i8h48ny6	89	13	.	.	.
cord-017640-i8h48ny6	90	1	Overall	overall	RB
cord-017640-i8h48ny6	90	2	,	,	,
cord-017640-i8h48ny6	90	3	the	the	DT
cord-017640-i8h48ny6	90	4	CD95-DD	cd95-dd	NN
cord-017640-i8h48ny6	90	5	/	/	SYM
cord-017640-i8h48ny6	90	6	FADD	FADD	NNP
cord-017640-i8h48ny6	90	7	-	-	HYPH
cord-017640-i8h48ny6	90	8	DD	DD	NNP
cord-017640-i8h48ny6	90	9	crystal	crystal	NN
cord-017640-i8h48ny6	90	10	structure	structure	NN
cord-017640-i8h48ny6	90	11	provides	provide	VBZ
cord-017640-i8h48ny6	90	12	some	some	DT
cord-017640-i8h48ny6	90	13	insights	insight	NNS
cord-017640-i8h48ny6	90	14	into	into	IN
cord-017640-i8h48ny6	90	15	the	the	DT
cord-017640-i8h48ny6	90	16	formation	formation	NN
cord-017640-i8h48ny6	90	17	of	of	IN
cord-017640-i8h48ny6	90	18	the	the	DT
cord-017640-i8h48ny6	90	19	large	large	JJ
cord-017640-i8h48ny6	90	20	CD95	CD95	NNP
cord-017640-i8h48ny6	90	21	clusters	cluster	NNS
cord-017640-i8h48ny6	90	22	observed	observe	VBD
cord-017640-i8h48ny6	90	23	using	use	VBG
cord-017640-i8h48ny6	90	24	imaging	image	VBG
cord-017640-i8h48ny6	90	25	or	or	CC
cord-017640-i8h48ny6	90	26	biochemical	biochemical	JJ
cord-017640-i8h48ny6	90	27	methods	method	NNS
cord-017640-i8h48ny6	90	28	in	in	IN
cord-017640-i8h48ny6	90	29	cells	cell	NNS
cord-017640-i8h48ny6	90	30	stimulated	stimulate	VBN
cord-017640-i8h48ny6	90	31	with	with	IN
cord-017640-i8h48ny6	90	32	CD95L.	CD95L.	NNP
cord-017640-i8h48ny6	91	1	In	in	IN
cord-017640-i8h48ny6	91	2	addition	addition	NN
cord-017640-i8h48ny6	91	3	,	,	,
cord-017640-i8h48ny6	91	4	it	-PRON-	PRP
cord-017640-i8h48ny6	91	5	also	also	RB
cord-017640-i8h48ny6	91	6	confirms	confirm	VBZ
cord-017640-i8h48ny6	91	7	that	that	IN
cord-017640-i8h48ny6	91	8	alteration	alteration	NN
cord-017640-i8h48ny6	91	9	in	in	IN
cord-017640-i8h48ny6	91	10	the	the	DT
cord-017640-i8h48ny6	91	11	CD95	CD95	NNP
cord-017640-i8h48ny6	91	12	conformation	conformation	NN
cord-017640-i8h48ny6	91	13	plays	play	VBZ
cord-017640-i8h48ny6	91	14	an	an	DT
cord-017640-i8h48ny6	91	15	instrumental	instrumental	JJ
cord-017640-i8h48ny6	91	16	role	role	NN
cord-017640-i8h48ny6	91	17	during	during	IN
cord-017640-i8h48ny6	91	18	signal	signal	NN
cord-017640-i8h48ny6	91	19	induction	induction	NN
cord-017640-i8h48ny6	91	20	[	[	-LRB-
cord-017640-i8h48ny6	91	21	68	68	CD
cord-017640-i8h48ny6	91	22	]	]	-RRB-
cord-017640-i8h48ny6	91	23	.	.	.
cord-017640-i8h48ny6	92	1	However	however	RB
cord-017640-i8h48ny6	92	2	,	,	,
cord-017640-i8h48ny6	92	3	this	this	DT
cord-017640-i8h48ny6	92	4	elongated	elongated	JJ
cord-017640-i8h48ny6	92	5	C	c	NN
cord-017640-i8h48ny6	92	6	-	-	HYPH
cord-017640-i8h48ny6	92	7	terminal	terminal	NN
cord-017640-i8h48ny6	92	8	α	α	NN
cord-017640-i8h48ny6	92	9	-	-	HYPH
cord-017640-i8h48ny6	92	10	helix	helix	NN
cord-017640-i8h48ny6	92	11	favoring	favor	VBG
cord-017640-i8h48ny6	92	12	the	the	DT
cord-017640-i8h48ny6	92	13	cis	cis	NNP
cord-017640-i8h48ny6	92	14	-	-	HYPH
cord-017640-i8h48ny6	92	15	dimerization	dimerization	NN
cord-017640-i8h48ny6	92	16	of	of	IN
cord-017640-i8h48ny6	92	17	CD95-DD	CD95-DD	NNP
cord-017640-i8h48ny6	92	18	was	be	VBD
cord-017640-i8h48ny6	92	19	challenged	challenge	VBN
cord-017640-i8h48ny6	92	20	by	by	IN
cord-017640-i8h48ny6	92	21	Driscoll	Driscoll	NNP
cord-017640-i8h48ny6	92	22	et	et	NNP
cord-017640-i8h48ny6	92	23	al	al	NNP
cord-017640-i8h48ny6	92	24	.	.	.
cord-017640-i8h48ny6	93	1	who	who	WP
cord-017640-i8h48ny6	93	2	did	do	VBD
cord-017640-i8h48ny6	93	3	not	not	RB
cord-017640-i8h48ny6	93	4	observe	observe	VB
cord-017640-i8h48ny6	93	5	the	the	DT
cord-017640-i8h48ny6	93	6	fusion	fusion	NN
cord-017640-i8h48ny6	93	7	of	of	IN
cord-017640-i8h48ny6	93	8	the	the	DT
cord-017640-i8h48ny6	93	9	last	last	JJ
cord-017640-i8h48ny6	93	10	two	two	CD
cord-017640-i8h48ny6	93	11	helices	helix	NNS
cord-017640-i8h48ny6	93	12	at	at	IN
cord-017640-i8h48ny6	93	13	a	a	DT
cord-017640-i8h48ny6	93	14	more	more	RBR
cord-017640-i8h48ny6	93	15	neutral	neutral	JJ
cord-017640-i8h48ny6	93	16	pH	ph	NN
cord-017640-i8h48ny6	93	17	(	(	-LRB-
cord-017640-i8h48ny6	93	18	pH	pH	NNP
cord-017640-i8h48ny6	93	19	6.2	6.2	CD
cord-017640-i8h48ny6	93	20	)	)	-RRB-
cord-017640-i8h48ny6	93	21	,	,	,
cord-017640-i8h48ny6	93	22	compared	compare	VBN
cord-017640-i8h48ny6	93	23	to	to	IN
cord-017640-i8h48ny6	93	24	the	the	DT
cord-017640-i8h48ny6	93	25	acidic	acidic	JJ
cord-017640-i8h48ny6	93	26	condition	condition	NN
cord-017640-i8h48ny6	93	27	(	(	-LRB-
cord-017640-i8h48ny6	93	28	pH	pH	NNP
cord-017640-i8h48ny6	93	29	4	4	CD
cord-017640-i8h48ny6	93	30	)	)	-RRB-
cord-017640-i8h48ny6	93	31	used	use	VBN
cord-017640-i8h48ny6	93	32	in	in	IN
cord-017640-i8h48ny6	93	33	the	the	DT
cord-017640-i8h48ny6	93	34	initial	initial	JJ
cord-017640-i8h48ny6	93	35	study	study	NN
cord-017640-i8h48ny6	93	36	to	to	TO
cord-017640-i8h48ny6	93	37	resolve	resolve	VB
cord-017640-i8h48ny6	93	38	the	the	DT
cord-017640-i8h48ny6	93	39	CD95-DD	CD95-DD	NNP
cord-017640-i8h48ny6	93	40	/	/	SYM
cord-017640-i8h48ny6	93	41	FADD	FADD	NNP
cord-017640-i8h48ny6	93	42	-	-	HYPH
cord-017640-i8h48ny6	93	43	DD	DD	NNP
cord-017640-i8h48ny6	93	44	structure	structure	NN
cord-017640-i8h48ny6	93	45	[	[	-LRB-
cord-017640-i8h48ny6	93	46	68	68	CD
cord-017640-i8h48ny6	93	47	]	]	-RRB-
cord-017640-i8h48ny6	93	48	.	.	.
cord-017640-i8h48ny6	94	1	Consequently	consequently	RB
cord-017640-i8h48ny6	94	2	,	,	,
cord-017640-i8h48ny6	94	3	at	at	IN
cord-017640-i8h48ny6	94	4	pH	pH	NNP
cord-017640-i8h48ny6	94	5	6.2	6.2	CD
cord-017640-i8h48ny6	94	6	,	,	,
cord-017640-i8h48ny6	94	7	association	association	NN
cord-017640-i8h48ny6	94	8	of	of	IN
cord-017640-i8h48ny6	94	9	CD95	CD95	NNP
cord-017640-i8h48ny6	94	10	with	with	IN
cord-017640-i8h48ny6	94	11	FADD	FADD	NNP
cord-017640-i8h48ny6	94	12	predominantly	predominantly	RB
cord-017640-i8h48ny6	94	13	consisted	consist	VBD
cord-017640-i8h48ny6	94	14	of	of	IN
cord-017640-i8h48ny6	94	15	a	a	DT
cord-017640-i8h48ny6	94	16	5:5	5:5	CD
cord-017640-i8h48ny6	94	17	complex	complex	NN
cord-017640-i8h48ny6	94	18	,	,	,
cord-017640-i8h48ny6	94	19	which	which	WDT
cord-017640-i8h48ny6	94	20	occurred	occur	VBD
cord-017640-i8h48ny6	94	21	via	via	IN
cord-017640-i8h48ny6	94	22	a	a	DT
cord-017640-i8h48ny6	94	23	polymerization	polymerization	NN
cord-017640-i8h48ny6	94	24	mechanism	mechanism	NN
cord-017640-i8h48ny6	94	25	involving	involve	VBG
cord-017640-i8h48ny6	94	26	three	three	CD
cord-017640-i8h48ny6	94	27	types	type	NNS
cord-017640-i8h48ny6	94	28	of	of	IN
cord-017640-i8h48ny6	94	29	asymmetric	asymmetric	JJ
cord-017640-i8h48ny6	94	30	interactions	interaction	NNS
cord-017640-i8h48ny6	94	31	but	but	CC
cord-017640-i8h48ny6	94	32	without	without	IN
cord-017640-i8h48ny6	94	33	major	major	JJ
cord-017640-i8h48ny6	94	34	alteration	alteration	NN
cord-017640-i8h48ny6	94	35	of	of	IN
cord-017640-i8h48ny6	94	36	the	the	DT
cord-017640-i8h48ny6	94	37	DD	DD	NNP
cord-017640-i8h48ny6	94	38	globular	globular	JJ
cord-017640-i8h48ny6	94	39	structure	structure	NN
cord-017640-i8h48ny6	94	40	[	[	-LRB-
cord-017640-i8h48ny6	94	41	69	69	CD
cord-017640-i8h48ny6	94	42	,	,	,
cord-017640-i8h48ny6	94	43	70	70	CD
cord-017640-i8h48ny6	94	44	]	]	-RRB-
cord-017640-i8h48ny6	94	45	.	.	.
cord-017640-i8h48ny6	95	1	It	-PRON-	PRP
cord-017640-i8h48ny6	95	2	is	be	VBZ
cord-017640-i8h48ny6	95	3	likely	likely	JJ
cord-017640-i8h48ny6	95	4	that	that	IN
cord-017640-i8h48ny6	95	5	the	the	DT
cord-017640-i8h48ny6	95	6	low	low	JJ
cord-017640-i8h48ny6	95	7	pH	pH	NNP
cord-017640-i8h48ny6	95	8	condition	condition	NN
cord-017640-i8h48ny6	95	9	used	use	VBN
cord-017640-i8h48ny6	95	10	in	in	IN
cord-017640-i8h48ny6	95	11	the	the	DT
cord-017640-i8h48ny6	95	12	study	study	NN
cord-017640-i8h48ny6	95	13	performed	perform	VBN
cord-017640-i8h48ny6	95	14	by	by	IN
cord-017640-i8h48ny6	95	15	Scott	Scott	NNP
cord-017640-i8h48ny6	95	16	et	et	NNP
cord-017640-i8h48ny6	95	17	al	al	NNP
cord-017640-i8h48ny6	95	18	.	.	.
cord-017640-i8h48ny6	96	1	altered	alter	VBN
cord-017640-i8h48ny6	96	2	CD95	CD95	NNP
cord-017640-i8h48ny6	96	3	conformation	conformation	NN
cord-017640-i8h48ny6	96	4	and	and	CC
cord-017640-i8h48ny6	96	5	resulted	result	VBD
cord-017640-i8h48ny6	96	6	in	in	IN
cord-017640-i8h48ny6	96	7	the	the	DT
cord-017640-i8h48ny6	96	8	formation	formation	NN
cord-017640-i8h48ny6	96	9	of	of	IN
cord-017640-i8h48ny6	96	10	nonphysiological	nonphysiological	JJ
cord-017640-i8h48ny6	96	11	CD95	CD95	NNP
cord-017640-i8h48ny6	96	12	/	/	SYM
cord-017640-i8h48ny6	96	13	FADD	FADD	NNP
cord-017640-i8h48ny6	96	14	oligomers	oligomer	NNS
cord-017640-i8h48ny6	96	15	[	[	-LRB-
cord-017640-i8h48ny6	96	16	68	68	CD
cord-017640-i8h48ny6	96	17	]	]	-RRB-
cord-017640-i8h48ny6	96	18	.	.	.
cord-017640-i8h48ny6	97	1	Nonetheless	nonetheless	RB
cord-017640-i8h48ny6	97	2	,	,	,
cord-017640-i8h48ny6	97	3	it	-PRON-	PRP
cord-017640-i8h48ny6	97	4	can	can	MD
cord-017640-i8h48ny6	97	5	not	not	RB
cord-017640-i8h48ny6	97	6	be	be	VB
cord-017640-i8h48ny6	97	7	excluded	exclude	VBN
cord-017640-i8h48ny6	97	8	that	that	IN
cord-017640-i8h48ny6	97	9	a	a	DT
cord-017640-i8h48ny6	97	10	local	local	JJ
cord-017640-i8h48ny6	97	11	decrease	decrease	NN
cord-017640-i8h48ny6	97	12	in	in	IN
cord-017640-i8h48ny6	97	13	the	the	DT
cord-017640-i8h48ny6	97	14	intracellular	intracellular	JJ
cord-017640-i8h48ny6	97	15	pH	pH	NNP
cord-017640-i8h48ny6	97	16	affects	affect	VBZ
cord-017640-i8h48ny6	97	17	the	the	DT
cord-017640-i8h48ny6	97	18	initial	initial	JJ
cord-017640-i8h48ny6	97	19	steps	step	NNS
cord-017640-i8h48ny6	97	20	of	of	IN
cord-017640-i8h48ny6	97	21	the	the	DT
cord-017640-i8h48ny6	97	22	CD95	CD95	NNP
cord-017640-i8h48ny6	97	23	signaling	signal	VBG
cord-017640-i8h48ny6	97	24	pathway	pathway	NN
cord-017640-i8h48ny6	97	25	in	in	IN
cord-017640-i8h48ny6	97	26	vivo	vivo	NN
cord-017640-i8h48ny6	97	27	,	,	,
cord-017640-i8h48ny6	97	28	through	through	IN
cord-017640-i8h48ny6	97	29	promoting	promote	VBG
cord-017640-i8h48ny6	97	30	the	the	DT
cord-017640-i8h48ny6	97	31	opening	opening	NN
cord-017640-i8h48ny6	97	32	of	of	IN
cord-017640-i8h48ny6	97	33	the	the	DT
cord-017640-i8h48ny6	97	34	CD95-DD	cd95-dd	NN
cord-017640-i8h48ny6	97	35	and	and	CC
cord-017640-i8h48ny6	97	36	eventually	eventually	RB
cord-017640-i8h48ny6	97	37	contributing	contribute	VBG
cord-017640-i8h48ny6	97	38	to	to	IN
cord-017640-i8h48ny6	97	39	the	the	DT
cord-017640-i8h48ny6	97	40	formation	formation	NN
cord-017640-i8h48ny6	97	41	of	of	IN
cord-017640-i8h48ny6	97	42	a	a	DT
cord-017640-i8h48ny6	97	43	complex	complex	NN
cord-017640-i8h48ny6	97	44	eliciting	elicit	VBG
cord-017640-i8h48ny6	97	45	a	a	DT
cord-017640-i8h48ny6	97	46	sequence	sequence	NN
cord-017640-i8h48ny6	97	47	of	of	IN
cord-017640-i8h48ny6	97	48	events	event	NNS
cord-017640-i8h48ny6	97	49	different	different	JJ
cord-017640-i8h48ny6	97	50	from	from	IN
cord-017640-i8h48ny6	97	51	the	the	DT
cord-017640-i8h48ny6	97	52	one	one	CD
cord-017640-i8h48ny6	97	53	occurring	occur	VBG
cord-017640-i8h48ny6	97	54	at	at	IN
cord-017640-i8h48ny6	97	55	physiologic	physiologic	JJ
cord-017640-i8h48ny6	97	56	pH.	ph.	NN
cord-017640-i8h48ny6	98	1	Once	once	RB
cord-017640-i8h48ny6	98	2	docked	dock	VBN
cord-017640-i8h48ny6	98	3	on	on	IN
cord-017640-i8h48ny6	98	4	CD95-DD	cd95-dd	NN
cord-017640-i8h48ny6	98	5	,	,	,
cord-017640-i8h48ny6	98	6	FADD	FADD	NNP
cord-017640-i8h48ny6	98	7	selfassociates	selfassociate	NNS
cord-017640-i8h48ny6	98	8	[	[	-LRB-
cord-017640-i8h48ny6	98	9	71	71	CD
cord-017640-i8h48ny6	98	10	]	]	-RRB-
cord-017640-i8h48ny6	98	11	and	and	CC
cord-017640-i8h48ny6	98	12	binds	bind	VBZ
cord-017640-i8h48ny6	98	13	procaspase-8	procaspase-8	NNP
cord-017640-i8h48ny6	98	14	and	and	CC
cord-017640-i8h48ny6	98	15	procaspase-10	procaspase-10	NNP
cord-017640-i8h48ny6	98	16	,	,	,
cord-017640-i8h48ny6	98	17	which	which	WDT
cord-017640-i8h48ny6	98	18	are	be	VBP
cord-017640-i8h48ny6	98	19	auto	auto	NN
cord-017640-i8h48ny6	98	20	-	-	HYPH
cord-017640-i8h48ny6	98	21	processed	process	VBN
cord-017640-i8h48ny6	98	22	and	and	CC
cord-017640-i8h48ny6	98	23	released	release	VBN
cord-017640-i8h48ny6	98	24	in	in	IN
cord-017640-i8h48ny6	98	25	the	the	DT
cord-017640-i8h48ny6	98	26	cytosol	cytosol	NN
cord-017640-i8h48ny6	98	27	as	as	IN
cord-017640-i8h48ny6	98	28	active	active	JJ
cord-017640-i8h48ny6	98	29	caspases	caspase	NNS
cord-017640-i8h48ny6	98	30	,	,	,
cord-017640-i8h48ny6	98	31	which	which	WDT
cord-017640-i8h48ny6	98	32	cleave	cleave	VBP
cord-017640-i8h48ny6	98	33	many	many	JJ
cord-017640-i8h48ny6	98	34	substrates	substrate	NNS
cord-017640-i8h48ny6	98	35	leading	lead	VBG
cord-017640-i8h48ny6	98	36	to	to	IN
cord-017640-i8h48ny6	98	37	the	the	DT
cord-017640-i8h48ny6	98	38	execution	execution	NN
cord-017640-i8h48ny6	98	39	of	of	IN
cord-017640-i8h48ny6	98	40	the	the	DT
cord-017640-i8h48ny6	98	41	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	98	42	program	program	NN
cord-017640-i8h48ny6	98	43	and	and	CC
cord-017640-i8h48ny6	98	44	cell	cell	NN
cord-017640-i8h48ny6	98	45	death	death	NN
cord-017640-i8h48ny6	98	46	.	.	.
cord-017640-i8h48ny6	99	1	The	the	DT
cord-017640-i8h48ny6	99	2	complex	complex	JJ
cord-017640-i8h48ny6	99	3	CD95	CD95	NNP
cord-017640-i8h48ny6	99	4	/	/	SYM
cord-017640-i8h48ny6	99	5	FADD	FADD	NNP
cord-017640-i8h48ny6	99	6	/	/	SYM
cord-017640-i8h48ny6	99	7	caspase-8/	caspase-8/	NNP
cord-017640-i8h48ny6	99	8	caspase-10	caspase-10	NN
cord-017640-i8h48ny6	99	9	is	be	VBZ
cord-017640-i8h48ny6	99	10	called	call	VBN
cord-017640-i8h48ny6	99	11	DISC	DISC	NNP
cord-017640-i8h48ny6	100	1	(	(	-LRB-
cord-017640-i8h48ny6	100	2	Fig	Fig	NNP
cord-017640-i8h48ny6	100	3	.	.	.
cord-017640-i8h48ny6	100	4	11	11	CD
cord-017640-i8h48ny6	101	1	the	the	DT
cord-017640-i8h48ny6	101	2	fate	fate	NN
cord-017640-i8h48ny6	101	3	of	of	IN
cord-017640-i8h48ny6	101	4	cells	cell	NNS
cord-017640-i8h48ny6	101	5	,	,	,
cord-017640-i8h48ny6	101	6	it	-PRON-	PRP
cord-017640-i8h48ny6	101	7	is	be	VBZ
cord-017640-i8h48ny6	101	8	not	not	RB
cord-017640-i8h48ny6	101	9	surprising	surprising	JJ
cord-017640-i8h48ny6	101	10	that	that	IN
cord-017640-i8h48ny6	101	11	numerous	numerous	JJ
cord-017640-i8h48ny6	101	12	cellular	cellular	JJ
cord-017640-i8h48ny6	101	13	and	and	CC
cord-017640-i8h48ny6	101	14	viral	viral	JJ
cord-017640-i8h48ny6	101	15	proteins	protein	NNS
cord-017640-i8h48ny6	101	16	were	be	VBD
cord-017640-i8h48ny6	101	17	reported	report	VBN
cord-017640-i8h48ny6	101	18	to	to	TO
cord-017640-i8h48ny6	101	19	hamper	hamper	VB
cord-017640-i8h48ny6	101	20	the	the	DT
cord-017640-i8h48ny6	101	21	formation	formation	NN
cord-017640-i8h48ny6	101	22	of	of	IN
cord-017640-i8h48ny6	101	23	this	this	DT
cord-017640-i8h48ny6	101	24	structure	structure	NN
cord-017640-i8h48ny6	101	25	,	,	,
cord-017640-i8h48ny6	101	26	such	such	JJ
cord-017640-i8h48ny6	101	27	as	as	IN
cord-017640-i8h48ny6	101	28	FLIP	FLIP	NNP
cord-017640-i8h48ny6	101	29	[	[	-LRB-
cord-017640-i8h48ny6	101	30	72	72	CD
cord-017640-i8h48ny6	101	31	,	,	,
cord-017640-i8h48ny6	101	32	73	73	CD
cord-017640-i8h48ny6	101	33	]	]	-RRB-
cord-017640-i8h48ny6	101	34	and	and	CC
cord-017640-i8h48ny6	101	35	PED	PED	NNP
cord-017640-i8h48ny6	101	36	/	/	SYM
cord-017640-i8h48ny6	101	37	PEA-15	PEA-15	NNP
cord-017640-i8h48ny6	101	38	[	[	-LRB-
cord-017640-i8h48ny6	101	39	74	74	CD
cord-017640-i8h48ny6	101	40	]	]	-RRB-
cord-017640-i8h48ny6	101	41	,	,	,
cord-017640-i8h48ny6	101	42	which	which	WDT
cord-017640-i8h48ny6	101	43	interfere	interfere	VBP
cord-017640-i8h48ny6	101	44	with	with	IN
cord-017640-i8h48ny6	101	45	the	the	DT
cord-017640-i8h48ny6	101	46	recruitment	recruitment	NN
cord-017640-i8h48ny6	101	47	of	of	IN
cord-017640-i8h48ny6	101	48	caspase-8/	caspase-8/	NNP
cord-017640-i8h48ny6	102	1	caspase-10	caspase-10	NN
cord-017640-i8h48ny6	102	2	(	(	-LRB-
cord-017640-i8h48ny6	102	3	Fig	Fig	NNP
cord-017640-i8h48ny6	102	4	.	.	.
cord-017640-i8h48ny6	103	1	11	11	CD
cord-017640-i8h48ny6	103	2	.2	.2	CD
cord-017640-i8h48ny6	103	3	)	)	-RRB-
cord-017640-i8h48ny6	103	4	.	.	.
cord-017640-i8h48ny6	104	1	Following	follow	VBG
cord-017640-i8h48ny6	104	2	the	the	DT
cord-017640-i8h48ny6	104	3	discovery	discovery	NN
cord-017640-i8h48ny6	104	4	of	of	IN
cord-017640-i8h48ny6	104	5	CD95	CD95	NNP
cord-017640-i8h48ny6	104	6	and	and	CC
cord-017640-i8h48ny6	104	7	the	the	DT
cord-017640-i8h48ny6	104	8	first	first	JJ
cord-017640-i8h48ny6	104	9	steps	step	NNS
cord-017640-i8h48ny6	104	10	of	of	IN
cord-017640-i8h48ny6	104	11	its	-PRON-	PRP$
cord-017640-i8h48ny6	104	12	signaling	signal	VBG
cord-017640-i8h48ny6	104	13	pathway	pathway	NN
cord-017640-i8h48ny6	104	14	,	,	,
cord-017640-i8h48ny6	104	15	Peter	Peter	NNP
cord-017640-i8h48ny6	104	16	and	and	CC
cord-017640-i8h48ny6	104	17	colleagues	colleague	NNS
cord-017640-i8h48ny6	104	18	described	describe	VBD
cord-017640-i8h48ny6	104	19	that	that	IN
cord-017640-i8h48ny6	104	20	cells	cell	NNS
cord-017640-i8h48ny6	104	21	can	can	MD
cord-017640-i8h48ny6	104	22	be	be	VB
cord-017640-i8h48ny6	104	23	divided	divide	VBN
cord-017640-i8h48ny6	104	24	in	in	IN
cord-017640-i8h48ny6	104	25	two	two	CD
cord-017640-i8h48ny6	104	26	groups	group	NNS
cord-017640-i8h48ny6	104	27	with	with	IN
cord-017640-i8h48ny6	104	28	regard	regard	NN
cord-017640-i8h48ny6	104	29	to	to	IN
cord-017640-i8h48ny6	104	30	the	the	DT
cord-017640-i8h48ny6	104	31	kinetics	kinetic	NNS
cord-017640-i8h48ny6	104	32	through	through	IN
cord-017640-i8h48ny6	104	33	which	which	WDT
cord-017640-i8h48ny6	104	34	they	-PRON-	PRP
cord-017640-i8h48ny6	104	35	respond	respond	VBP
cord-017640-i8h48ny6	104	36	to	to	IN
cord-017640-i8h48ny6	104	37	CD95-mediated	cd95-mediated	CD
cord-017640-i8h48ny6	104	38	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	104	39	signals	signal	NNS
cord-017640-i8h48ny6	104	40	,	,	,
cord-017640-i8h48ny6	104	41	the	the	DT
cord-017640-i8h48ny6	104	42	magnitude	magnitude	NN
cord-017640-i8h48ny6	104	43	of	of	IN
cord-017640-i8h48ny6	104	44	DISC	disc	NN
cord-017640-i8h48ny6	104	45	formation	formation	NN
cord-017640-i8h48ny6	104	46	,	,	,
cord-017640-i8h48ny6	104	47	and	and	CC
cord-017640-i8h48ny6	104	48	the	the	DT
cord-017640-i8h48ny6	104	49	role	role	NN
cord-017640-i8h48ny6	104	50	played	play	VBN
cord-017640-i8h48ny6	104	51	by	by	IN
cord-017640-i8h48ny6	104	52	the	the	DT
cord-017640-i8h48ny6	104	53	mitochondrion	mitochondrion	NN
cord-017640-i8h48ny6	104	54	in	in	IN
cord-017640-i8h48ny6	104	55	this	this	DT
cord-017640-i8h48ny6	104	56	pathway	pathway	NN
cord-017640-i8h48ny6	104	57	[	[	-LRB-
cord-017640-i8h48ny6	104	58	75	75	CD
cord-017640-i8h48ny6	104	59	]	]	-RRB-
cord-017640-i8h48ny6	104	60	.	.	.
cord-017640-i8h48ny6	105	1	DISC	disc	NN
cord-017640-i8h48ny6	105	2	formation	formation	NN
cord-017640-i8h48ny6	105	3	occurs	occur	VBZ
cord-017640-i8h48ny6	105	4	rapidly	rapidly	RB
cord-017640-i8h48ny6	105	5	and	and	CC
cord-017640-i8h48ny6	105	6	efficiently	efficiently	RB
cord-017640-i8h48ny6	105	7	in	in	IN
cord-017640-i8h48ny6	105	8	type	type	NN
cord-017640-i8h48ny6	106	1	I	-PRON-	PRP
cord-017640-i8h48ny6	106	2	cells	cells	VBP
cord-017640-i8h48ny6	106	3	releasing	release	VBG
cord-017640-i8h48ny6	106	4	a	a	DT
cord-017640-i8h48ny6	106	5	large	large	JJ
cord-017640-i8h48ny6	106	6	amount	amount	NN
cord-017640-i8h48ny6	106	7	of	of	IN
cord-017640-i8h48ny6	106	8	activated	activate	VBN
cord-017640-i8h48ny6	106	9	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	106	10	in	in	IN
cord-017640-i8h48ny6	106	11	the	the	DT
cord-017640-i8h48ny6	106	12	cytosol	cytosol	NN
cord-017640-i8h48ny6	106	13	,	,	,
cord-017640-i8h48ny6	106	14	while	while	IN
cord-017640-i8h48ny6	106	15	type	type	NN
cord-017640-i8h48ny6	106	16	II	ii	CD
cord-017640-i8h48ny6	106	17	cells	cell	NNS
cord-017640-i8h48ny6	106	18	have	have	VBP
cord-017640-i8h48ny6	106	19	difficulty	difficulty	NN
cord-017640-i8h48ny6	106	20	forming	form	VBG
cord-017640-i8h48ny6	106	21	this	this	DT
cord-017640-i8h48ny6	106	22	complex	complex	NN
cord-017640-i8h48ny6	106	23	,	,	,
cord-017640-i8h48ny6	106	24	and	and	CC
cord-017640-i8h48ny6	106	25	the	the	DT
cord-017640-i8h48ny6	106	26	amount	amount	NN
cord-017640-i8h48ny6	106	27	of	of	IN
cord-017640-i8h48ny6	106	28	active	active	JJ
cord-017640-i8h48ny6	106	29	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	106	30	is	be	VBZ
cord-017640-i8h48ny6	106	31	insufficient	insufficient	JJ
cord-017640-i8h48ny6	106	32	to	to	TO
cord-017640-i8h48ny6	106	33	directly	directly	RB
cord-017640-i8h48ny6	106	34	activate	activate	VB
cord-017640-i8h48ny6	106	35	the	the	DT
cord-017640-i8h48ny6	106	36	effectors	effector	NNS
cord-017640-i8h48ny6	106	37	caspase-3	caspase-3	NNP
cord-017640-i8h48ny6	106	38	and	and	CC
cord-017640-i8h48ny6	106	39	caspase-7	caspase-7	NNP
cord-017640-i8h48ny6	106	40	[	[	-LRB-
cord-017640-i8h48ny6	106	41	75	75	CD
cord-017640-i8h48ny6	106	42	]	]	-RRB-
cord-017640-i8h48ny6	106	43	.	.	.
cord-017640-i8h48ny6	107	1	Nonetheless	nonetheless	RB
cord-017640-i8h48ny6	107	2	,	,	,
cord-017640-i8h48ny6	107	3	type	type	NN
cord-017640-i8h48ny6	107	4	II	ii	CD
cord-017640-i8h48ny6	107	5	cells	cell	NNS
cord-017640-i8h48ny6	107	6	experience	experience	VBP
cord-017640-i8h48ny6	107	7	cell	cell	NN
cord-017640-i8h48ny6	107	8	death	death	NN
cord-017640-i8h48ny6	107	9	upon	upon	IN
cord-017640-i8h48ny6	107	10	CD95	CD95	NNP
cord-017640-i8h48ny6	107	11	engagement	engagement	NN
cord-017640-i8h48ny6	107	12	and	and	CC
cord-017640-i8h48ny6	107	13	are	be	VBP
cord-017640-i8h48ny6	107	14	even	even	RB
cord-017640-i8h48ny6	107	15	more	more	RBR
cord-017640-i8h48ny6	107	16	sensitive	sensitive	JJ
cord-017640-i8h48ny6	107	17	to	to	IN
cord-017640-i8h48ny6	107	18	the	the	DT
cord-017640-i8h48ny6	107	19	CD95-mediated	cd95-mediated	CD
cord-017640-i8h48ny6	107	20	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	107	21	signal	signal	NN
cord-017640-i8h48ny6	107	22	compared	compare	VBN
cord-017640-i8h48ny6	107	23	to	to	IN
cord-017640-i8h48ny6	107	24	type	type	NN
cord-017640-i8h48ny6	107	25	I	-PRON-	PRP
cord-017640-i8h48ny6	107	26	cells	cells	VBP
cord-017640-i8h48ny6	107	27	[	[	-LRB-
cord-017640-i8h48ny6	107	28	75	75	CD
cord-017640-i8h48ny6	107	29	]	]	-RRB-
cord-017640-i8h48ny6	108	1	[	[	-LRB-
cord-017640-i8h48ny6	108	2	76	76	CD
cord-017640-i8h48ny6	108	3	]	]	-RRB-
cord-017640-i8h48ny6	108	4	[	[	-LRB-
cord-017640-i8h48ny6	108	5	77	77	CD
cord-017640-i8h48ny6	108	6	]	]	-RRB-
cord-017640-i8h48ny6	108	7	.	.	.
cord-017640-i8h48ny6	109	1	This	this	DT
cord-017640-i8h48ny6	109	2	discrepancy	discrepancy	NN
cord-017640-i8h48ny6	109	3	can	can	MD
cord-017640-i8h48ny6	109	4	be	be	VB
cord-017640-i8h48ny6	109	5	partly	partly	RB
cord-017640-i8h48ny6	109	6	explained	explain	VBN
cord-017640-i8h48ny6	109	7	by	by	IN
cord-017640-i8h48ny6	109	8	the	the	DT
cord-017640-i8h48ny6	109	9	fact	fact	NN
cord-017640-i8h48ny6	109	10	that	that	IN
cord-017640-i8h48ny6	109	11	the	the	DT
cord-017640-i8h48ny6	109	12	low	low	JJ
cord-017640-i8h48ny6	109	13	amount	amount	NN
cord-017640-i8h48ny6	109	14	of	of	IN
cord-017640-i8h48ny6	109	15	activated	activate	VBN
cord-017640-i8h48ny6	109	16	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	109	17	in	in	IN
cord-017640-i8h48ny6	109	18	type	type	NN
cord-017640-i8h48ny6	109	19	II	ii	CD
cord-017640-i8h48ny6	109	20	cells	cell	NNS
cord-017640-i8h48ny6	109	21	is	be	VBZ
cord-017640-i8h48ny6	109	22	sufficient	sufficient	JJ
cord-017640-i8h48ny6	109	23	to	to	TO
cord-017640-i8h48ny6	109	24	cleave	cleave	VB
cord-017640-i8h48ny6	109	25	BID	BID	NNP
cord-017640-i8h48ny6	109	26	,	,	,
cord-017640-i8h48ny6	109	27	a	a	DT
cord-017640-i8h48ny6	109	28	BH3-only	bh3-only	NN
cord-017640-i8h48ny6	109	29	protein	protein	NN
cord-017640-i8h48ny6	109	30	,	,	,
cord-017640-i8h48ny6	109	31	which	which	WDT
cord-017640-i8h48ny6	109	32	constitutes	constitute	VBZ
cord-017640-i8h48ny6	109	33	the	the	DT
cord-017640-i8h48ny6	109	34	molecular	molecular	JJ
cord-017640-i8h48ny6	109	35	link	link	NN
cord-017640-i8h48ny6	109	36	between	between	IN
cord-017640-i8h48ny6	109	37	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	109	38	activation	activation	NN
cord-017640-i8h48ny6	109	39	and	and	CC
cord-017640-i8h48ny6	109	40	the	the	DT
cord-017640-i8h48ny6	109	41	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	109	42	activity	activity	NN
cord-017640-i8h48ny6	109	43	of	of	IN
cord-017640-i8h48ny6	109	44	mitochondria	mitochondrion	NNS
cord-017640-i8h48ny6	109	45	.	.	.
cord-017640-i8h48ny6	110	1	Indeed	indeed	RB
cord-017640-i8h48ny6	110	2	,	,	,
cord-017640-i8h48ny6	110	3	after	after	IN
cord-017640-i8h48ny6	110	4	cleavage	cleavage	NN
cord-017640-i8h48ny6	110	5	by	by	IN
cord-017640-i8h48ny6	110	6	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	110	7	,	,	,
cord-017640-i8h48ny6	110	8	truncated	truncated	JJ
cord-017640-i8h48ny6	110	9	BID	bid	NN
cord-017640-i8h48ny6	110	10	(	(	-LRB-
cord-017640-i8h48ny6	110	11	tBID	tBID	NNS
cord-017640-i8h48ny6	110	12	)	)	-RRB-
cord-017640-i8h48ny6	110	13	translocates	translocate	NNS
cord-017640-i8h48ny6	110	14	to	to	IN
cord-017640-i8h48ny6	110	15	mitochondria	mitochondrion	NNS
cord-017640-i8h48ny6	110	16	,	,	,
cord-017640-i8h48ny6	110	17	where	where	WRB
cord-017640-i8h48ny6	110	18	it	-PRON-	PRP
cord-017640-i8h48ny6	110	19	triggers	trigger	VBZ
cord-017640-i8h48ny6	110	20	the	the	DT
cord-017640-i8h48ny6	110	21	release	release	NN
cord-017640-i8h48ny6	110	22	of	of	IN
cord-017640-i8h48ny6	110	23	proapoptotic	proapoptotic	JJ
cord-017640-i8h48ny6	110	24	factors	factor	NNS
cord-017640-i8h48ny6	110	25	(	(	-LRB-
cord-017640-i8h48ny6	110	26	Fig	fig	NN
cord-017640-i8h48ny6	110	27	.	.	.
cord-017640-i8h48ny6	111	1	11	11	CD
cord-017640-i8h48ny6	111	2	.2	.2	CD
cord-017640-i8h48ny6	111	3	)	)	-RRB-
cord-017640-i8h48ny6	112	1	[	[	-LRB-
cord-017640-i8h48ny6	112	2	78	78	CD
cord-017640-i8h48ny6	112	3	,	,	,
cord-017640-i8h48ny6	112	4	79	79	CD
cord-017640-i8h48ny6	112	5	]	]	-RRB-
cord-017640-i8h48ny6	112	6	.	.	.
cord-017640-i8h48ny6	113	1	Although	although	IN
cord-017640-i8h48ny6	113	2	CD95	CD95	NNP
cord-017640-i8h48ny6	113	3	stimulation	stimulation	NN
cord-017640-i8h48ny6	113	4	activates	activate	VBZ
cord-017640-i8h48ny6	113	5	the	the	DT
cord-017640-i8h48ny6	113	6	mitochondrion	mitochondrion	NN
cord-017640-i8h48ny6	113	7	-	-	HYPH
cord-017640-i8h48ny6	113	8	dependent	dependent	JJ
cord-017640-i8h48ny6	113	9	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	113	10	signal	signal	NN
cord-017640-i8h48ny6	113	11	in	in	IN
cord-017640-i8h48ny6	113	12	type	type	NN
cord-017640-i8h48ny6	113	13	I	-PRON-	PRP
cord-017640-i8h48ny6	113	14	and	and	CC
cord-017640-i8h48ny6	113	15	type	type	NN
cord-017640-i8h48ny6	113	16	II	ii	CD
cord-017640-i8h48ny6	113	17	cells	cell	NNS
cord-017640-i8h48ny6	113	18	,	,	,
cord-017640-i8h48ny6	113	19	it	-PRON-	PRP
cord-017640-i8h48ny6	113	20	seems	seem	VBZ
cord-017640-i8h48ny6	113	21	that	that	IN
cord-017640-i8h48ny6	113	22	only	only	JJ
cord-017640-i8h48ny6	113	23	type	type	NN
cord-017640-i8h48ny6	113	24	II	ii	CD
cord-017640-i8h48ny6	113	25	cells	cell	NNS
cord-017640-i8h48ny6	113	26	are	be	VBP
cord-017640-i8h48ny6	113	27	addicted	addicted	JJ
cord-017640-i8h48ny6	113	28	to	to	IN
cord-017640-i8h48ny6	113	29	this	this	DT
cord-017640-i8h48ny6	113	30	signal	signal	NN
cord-017640-i8h48ny6	113	31	as	as	IN
cord-017640-i8h48ny6	113	32	they	-PRON-	PRP
cord-017640-i8h48ny6	113	33	display	display	VBP
cord-017640-i8h48ny6	113	34	a	a	DT
cord-017640-i8h48ny6	113	35	higher	high	JJR
cord-017640-i8h48ny6	113	36	amount	amount	NN
cord-017640-i8h48ny6	113	37	of	of	IN
cord-017640-i8h48ny6	113	38	the	the	DT
cord-017640-i8h48ny6	113	39	caspase-3	caspase-3	NNP
cord-017640-i8h48ny6	113	40	inhibitor	inhibitor	NN
cord-017640-i8h48ny6	113	41	XIAP	xiap	NN
cord-017640-i8h48ny6	113	42	compared	compare	VBN
cord-017640-i8h48ny6	113	43	to	to	IN
cord-017640-i8h48ny6	113	44	type	type	NN
cord-017640-i8h48ny6	113	45	I	-PRON-	PRP
cord-017640-i8h48ny6	113	46	cells	cells	VBP
cord-017640-i8h48ny6	113	47	[	[	-LRB-
cord-017640-i8h48ny6	113	48	80	80	CD
cord-017640-i8h48ny6	113	49	]	]	-RRB-
cord-017640-i8h48ny6	113	50	.	.	.
cord-017640-i8h48ny6	114	1	Among	among	IN
cord-017640-i8h48ny6	114	2	the	the	DT
cord-017640-i8h48ny6	114	3	inhibitor	inhibitor	NN
cord-017640-i8h48ny6	114	4	of	of	IN
cord-017640-i8h48ny6	114	5	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	114	6	protein	protein	NN
cord-017640-i8h48ny6	114	7	(	(	-LRB-
cord-017640-i8h48ny6	114	8	IAP	IAP	NNP
cord-017640-i8h48ny6	114	9	)	)	-RRB-
cord-017640-i8h48ny6	114	10	family	family	NN
cord-017640-i8h48ny6	114	11	,	,	,
cord-017640-i8h48ny6	114	12	XIAP	XIAP	NNP
cord-017640-i8h48ny6	114	13	,	,	,
cord-017640-i8h48ny6	114	14	cIAP1	ciap1	NN
cord-017640-i8h48ny6	114	15	,	,	,
cord-017640-i8h48ny6	114	16	and	and	CC
cord-017640-i8h48ny6	114	17	cIAP2	ciap2	PRP
cord-017640-i8h48ny6	114	18	inhibit	inhibit	VBP
cord-017640-i8h48ny6	114	19	caspase-3	caspase-3	NNP
cord-017640-i8h48ny6	114	20	,	,	,
cord-017640-i8h48ny6	114	21	caspase-7	caspase-7	NNP
cord-017640-i8h48ny6	114	22	[	[	-LRB-
cord-017640-i8h48ny6	114	23	81	81	CD
cord-017640-i8h48ny6	114	24	,	,	,
cord-017640-i8h48ny6	114	25	82	82	CD
cord-017640-i8h48ny6	114	26	]	]	-RRB-
cord-017640-i8h48ny6	114	27	,	,	,
cord-017640-i8h48ny6	114	28	and	and	CC
cord-017640-i8h48ny6	114	29	procaspase-9	procaspase-9	NNP
cord-017640-i8h48ny6	114	30	[	[	-LRB-
cord-017640-i8h48ny6	114	31	83	83	CD
cord-017640-i8h48ny6	114	32	]	]	-RRB-
cord-017640-i8h48ny6	114	33	activity	activity	NN
cord-017640-i8h48ny6	114	34	by	by	IN
cord-017640-i8h48ny6	114	35	direct	direct	JJ
cord-017640-i8h48ny6	114	36	binding	binding	NN
cord-017640-i8h48ny6	114	37	,	,	,
cord-017640-i8h48ny6	114	38	thereby	thereby	RB
cord-017640-i8h48ny6	114	39	preventing	prevent	VBG
cord-017640-i8h48ny6	114	40	access	access	NN
cord-017640-i8h48ny6	114	41	to	to	IN
cord-017640-i8h48ny6	114	42	substrates	substrate	NNS
cord-017640-i8h48ny6	114	43	.	.	.
cord-017640-i8h48ny6	115	1	Furthermore	furthermore	RB
cord-017640-i8h48ny6	115	2	,	,	,
cord-017640-i8h48ny6	115	3	XIAP	XIAP	NNP
cord-017640-i8h48ny6	115	4	can	can	MD
cord-017640-i8h48ny6	115	5	function	function	VB
cord-017640-i8h48ny6	115	6	as	as	IN
cord-017640-i8h48ny6	115	7	an	an	DT
cord-017640-i8h48ny6	115	8	E3	e3	NN
cord-017640-i8h48ny6	115	9	ligase	ligase	NN
cord-017640-i8h48ny6	115	10	whose	whose	WP$
cord-017640-i8h48ny6	115	11	activity	activity	NN
cord-017640-i8h48ny6	115	12	is	be	VBZ
cord-017640-i8h48ny6	115	13	involved	involve	VBN
cord-017640-i8h48ny6	115	14	in	in	IN
cord-017640-i8h48ny6	115	15	the	the	DT
cord-017640-i8h48ny6	115	16	ubiquitination	ubiquitination	NN
cord-017640-i8h48ny6	115	17	of	of	IN
cord-017640-i8h48ny6	115	18	active	active	JJ
cord-017640-i8h48ny6	115	19	caspase-3	caspase-3	NNP
cord-017640-i8h48ny6	115	20	and	and	CC
cord-017640-i8h48ny6	115	21	its	-PRON-	PRP$
cord-017640-i8h48ny6	115	22	subsequent	subsequent	JJ
cord-017640-i8h48ny6	115	23	degradation	degradation	NN
cord-017640-i8h48ny6	115	24	through	through	IN
cord-017640-i8h48ny6	115	25	the	the	DT
cord-017640-i8h48ny6	115	26	proteasome	proteasome	NN
cord-017640-i8h48ny6	115	27	[	[	-LRB-
cord-017640-i8h48ny6	115	28	84	84	CD
cord-017640-i8h48ny6	115	29	]	]	-RRB-
cord-017640-i8h48ny6	115	30	.	.	.
cord-017640-i8h48ny6	116	1	To	to	TO
cord-017640-i8h48ny6	116	2	detach	detach	VB
cord-017640-i8h48ny6	116	3	XIAP	xiap	NN
cord-017640-i8h48ny6	116	4	from	from	IN
cord-017640-i8h48ny6	116	5	caspase-3	caspase-3	NNP
cord-017640-i8h48ny6	116	6	and	and	CC
cord-017640-i8h48ny6	116	7	restore	restore	VB
cord-017640-i8h48ny6	116	8	the	the	DT
cord-017640-i8h48ny6	116	9	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	116	10	signal	signal	NN
cord-017640-i8h48ny6	116	11	,	,	,
cord-017640-i8h48ny6	116	12	cells	cell	NNS
cord-017640-i8h48ny6	116	13	require	require	VBP
cord-017640-i8h48ny6	116	14	the	the	DT
cord-017640-i8h48ny6	116	15	release	release	NN
cord-017640-i8h48ny6	116	16	of	of	IN
cord-017640-i8h48ny6	116	17	SMAC	SMAC	NNP
cord-017640-i8h48ny6	116	18	/	/	SYM
cord-017640-i8h48ny6	116	19	DIABLO	DIABLO	NNP
cord-017640-i8h48ny6	116	20	(	(	-LRB-
cord-017640-i8h48ny6	116	21	second	second	JJ
cord-017640-i8h48ny6	116	22	mitochondria	mitochondria	NN
cord-017640-i8h48ny6	116	23	-	-	HYPH
cord-017640-i8h48ny6	116	24	derived	derive	VBN
cord-017640-i8h48ny6	116	25	activator	activator	NN
cord-017640-i8h48ny6	116	26	of	of	IN
cord-017640-i8h48ny6	116	27	caspase/	caspase/	JJS
cord-017640-i8h48ny6	116	28	direct	direct	JJ
cord-017640-i8h48ny6	116	29	IAP	IAP	NNP
cord-017640-i8h48ny6	116	30	-	-	HYPH
cord-017640-i8h48ny6	116	31	binding	bind	VBG
cord-017640-i8h48ny6	116	32	protein	protein	NN
cord-017640-i8h48ny6	116	33	with	with	IN
cord-017640-i8h48ny6	116	34	low	low	JJ
cord-017640-i8h48ny6	116	35	PI	pi	NN
cord-017640-i8h48ny6	116	36	)	)	-RRB-
cord-017640-i8h48ny6	116	37	by	by	IN
cord-017640-i8h48ny6	116	38	the	the	DT
cord-017640-i8h48ny6	116	39	mitochondrion	mitochondrion	NN
cord-017640-i8h48ny6	116	40	[	[	-LRB-
cord-017640-i8h48ny6	116	41	85	85	CD
cord-017640-i8h48ny6	116	42	,	,	,
cord-017640-i8h48ny6	116	43	86	86	CD
cord-017640-i8h48ny6	116	44	]	]	-RRB-
cord-017640-i8h48ny6	116	45	,	,	,
cord-017640-i8h48ny6	116	46	explaining	explain	VBG
cord-017640-i8h48ny6	116	47	why	why	WRB
cord-017640-i8h48ny6	116	48	type	type	NN
cord-017640-i8h48ny6	116	49	II	ii	CD
cord-017640-i8h48ny6	116	50	cells	cell	NNS
cord-017640-i8h48ny6	116	51	are	be	VBP
cord-017640-i8h48ny6	116	52	more	more	RBR
cord-017640-i8h48ny6	116	53	addicted	addicted	JJ
cord-017640-i8h48ny6	116	54	to	to	IN
cord-017640-i8h48ny6	116	55	this	this	DT
cord-017640-i8h48ny6	116	56	organelle	organelle	NN
cord-017640-i8h48ny6	116	57	compared	compare	VBN
cord-017640-i8h48ny6	116	58	to	to	IN
cord-017640-i8h48ny6	116	59	type	type	NN
cord-017640-i8h48ny6	116	60	I	-PRON-	PRP
cord-017640-i8h48ny6	116	61	cells	cell	NNS
cord-017640-i8h48ny6	116	62	(	(	-LRB-
cord-017640-i8h48ny6	116	63	Fig	fig	NN
cord-017640-i8h48ny6	116	64	.	.	.
cord-017640-i8h48ny6	116	65	11	11	CD
cord-017640-i8h48ny6	116	66	.2	.2	CD
cord-017640-i8h48ny6	116	67	)	)	-RRB-
cord-017640-i8h48ny6	116	68	.	.	.
cord-017640-i8h48ny6	117	1	To	to	TO
cord-017640-i8h48ny6	117	2	summarize	summarize	VB
cord-017640-i8h48ny6	117	3	,	,	,
cord-017640-i8h48ny6	117	4	DISC	disc	VB
cord-017640-i8h48ny6	117	5	formation	formation	NN
cord-017640-i8h48ny6	117	6	and	and	CC
cord-017640-i8h48ny6	117	7	IAP	IAP	NNP
cord-017640-i8h48ny6	117	8	amount	amount	NN
cord-017640-i8h48ny6	117	9	are	be	VBP
cord-017640-i8h48ny6	117	10	two	two	CD
cord-017640-i8h48ny6	117	11	cellular	cellular	JJ
cord-017640-i8h48ny6	117	12	markers	marker	NNS
cord-017640-i8h48ny6	117	13	allowing	allow	VBG
cord-017640-i8h48ny6	117	14	a	a	DT
cord-017640-i8h48ny6	117	15	clear	clear	JJ
cord-017640-i8h48ny6	117	16	discrimination	discrimination	NN
cord-017640-i8h48ny6	117	17	between	between	IN
cord-017640-i8h48ny6	117	18	type	type	NN
cord-017640-i8h48ny6	117	19	I	-PRON-	PRP
cord-017640-i8h48ny6	117	20	and	and	CC
cord-017640-i8h48ny6	117	21	type	type	NN
cord-017640-i8h48ny6	117	22	II	ii	CD
cord-017640-i8h48ny6	117	23	cells	cell	NNS
cord-017640-i8h48ny6	117	24	.	.	.
cord-017640-i8h48ny6	118	1	Even	even	RB
cord-017640-i8h48ny6	118	2	though	though	IN
cord-017640-i8h48ny6	118	3	IAP	IAP	NNP
cord-017640-i8h48ny6	118	4	overexpression	overexpression	NN
cord-017640-i8h48ny6	118	5	can	can	MD
cord-017640-i8h48ny6	118	6	account	account	VB
cord-017640-i8h48ny6	118	7	for	for	IN
cord-017640-i8h48ny6	118	8	the	the	DT
cord-017640-i8h48ny6	118	9	mitochondrion	mitochondrion	NN
cord-017640-i8h48ny6	118	10	dependency	dependency	NN
cord-017640-i8h48ny6	118	11	observed	observe	VBN
cord-017640-i8h48ny6	118	12	in	in	IN
cord-017640-i8h48ny6	118	13	type	type	NN
cord-017640-i8h48ny6	118	14	II	ii	CD
cord-017640-i8h48ny6	118	15	cells	cell	NNS
cord-017640-i8h48ny6	118	16	,	,	,
cord-017640-i8h48ny6	118	17	it	-PRON-	PRP
cord-017640-i8h48ny6	118	18	remains	remain	VBZ
cord-017640-i8h48ny6	118	19	unclear	unclear	JJ
cord-017640-i8h48ny6	118	20	why	why	WRB
cord-017640-i8h48ny6	118	21	DISC	disc	NN
cord-017640-i8h48ny6	118	22	formation	formation	NN
cord-017640-i8h48ny6	118	23	is	be	VBZ
cord-017640-i8h48ny6	118	24	hampered	hamper	VBN
cord-017640-i8h48ny6	118	25	in	in	IN
cord-017640-i8h48ny6	118	26	type	type	NN
cord-017640-i8h48ny6	118	27	II	ii	CD
cord-017640-i8h48ny6	118	28	cells	cell	NNS
cord-017640-i8h48ny6	118	29	and/or	and/or	CC
cord-017640-i8h48ny6	118	30	enhanced	enhance	VBN
cord-017640-i8h48ny6	118	31	in	in	IN
cord-017640-i8h48ny6	118	32	their	-PRON-	PRP$
cord-017640-i8h48ny6	118	33	type	type	NN
cord-017640-i8h48ny6	118	34	I	-PRON-	PRP
cord-017640-i8h48ny6	118	35	counterparts	counterpart	NNS
cord-017640-i8h48ny6	118	36	.	.	.
cord-017640-i8h48ny6	119	1	Recently	recently	RB
cord-017640-i8h48ny6	119	2	,	,	,
cord-017640-i8h48ny6	119	3	high	high	JJ
cord-017640-i8h48ny6	119	4	activity	activity	NN
cord-017640-i8h48ny6	119	5	of	of	IN
cord-017640-i8h48ny6	119	6	the	the	DT
cord-017640-i8h48ny6	119	7	lipid	lipid	NN
cord-017640-i8h48ny6	119	8	kinase	kinase	NN
cord-017640-i8h48ny6	119	9	phosphoinositide	phosphoinositide	NNP
cord-017640-i8h48ny6	119	10	3-kinase	3-kinase	CD
cord-017640-i8h48ny6	119	11	(	(	-LRB-
cord-017640-i8h48ny6	119	12	PI3	PI3	NNP
cord-017640-i8h48ny6	119	13	K	K	NNP
cord-017640-i8h48ny6	119	14	)	)	-RRB-
cord-017640-i8h48ny6	119	15	or	or	CC
cord-017640-i8h48ny6	119	16	downregulation	downregulation	NN
cord-017640-i8h48ny6	119	17	of	of	IN
cord-017640-i8h48ny6	119	18	its	-PRON-	PRP$
cord-017640-i8h48ny6	119	19	neutralizing	neutralize	VBG
cord-017640-i8h48ny6	119	20	phosphatase	phosphatase	NN
cord-017640-i8h48ny6	119	21	,	,	,
cord-017640-i8h48ny6	119	22	phosphatase	phosphatase	NN
cord-017640-i8h48ny6	119	23	and	and	CC
cord-017640-i8h48ny6	119	24	tensin	tensin	NNP
cord-017640-i8h48ny6	119	25	homologue	homologue	NN
cord-017640-i8h48ny6	119	26	on	on	IN
cord-017640-i8h48ny6	119	27	chromosome	chromosome	NN
cord-017640-i8h48ny6	119	28	10	10	CD
cord-017640-i8h48ny6	119	29	(	(	-LRB-
cord-017640-i8h48ny6	119	30	PTEN	PTEN	NNP
cord-017640-i8h48ny6	119	31	)	)	-RRB-
cord-017640-i8h48ny6	119	32	,	,	,
cord-017640-i8h48ny6	119	33	was	be	VBD
cord-017640-i8h48ny6	119	34	found	find	VBN
cord-017640-i8h48ny6	119	35	in	in	IN
cord-017640-i8h48ny6	119	36	type	type	NN
cord-017640-i8h48ny6	119	37	II	ii	CD
cord-017640-i8h48ny6	119	38	cells	cell	NNS
cord-017640-i8h48ny6	119	39	,	,	,
cord-017640-i8h48ny6	119	40	while	while	IN
cord-017640-i8h48ny6	119	41	this	this	DT
cord-017640-i8h48ny6	119	42	signal	signal	NN
cord-017640-i8h48ny6	119	43	is	be	VBZ
cord-017640-i8h48ny6	119	44	blocked	block	VBN
cord-017640-i8h48ny6	119	45	in	in	IN
cord-017640-i8h48ny6	119	46	type	type	NN
cord-017640-i8h48ny6	119	47	I	-PRON-	PRP
cord-017640-i8h48ny6	119	48	cell	cell	NN
cord-017640-i8h48ny6	119	49	lines	line	NNS
cord-017640-i8h48ny6	119	50	[	[	-LRB-
cord-017640-i8h48ny6	119	51	87	87	CD
cord-017640-i8h48ny6	119	52	,	,	,
cord-017640-i8h48ny6	119	53	88	88	CD
cord-017640-i8h48ny6	119	54	]	]	-RRB-
cord-017640-i8h48ny6	119	55	.	.	.
cord-017640-i8h48ny6	120	1	The	the	DT
cord-017640-i8h48ny6	120	2	PI3	pi3	NN
cord-017640-i8h48ny6	120	3	K	K	NNP
cord-017640-i8h48ny6	120	4	signaling	signal	VBG
cord-017640-i8h48ny6	120	5	pathway	pathway	NN
cord-017640-i8h48ny6	120	6	was	be	VBD
cord-017640-i8h48ny6	120	7	reported	report	VBN
cord-017640-i8h48ny6	120	8	to	to	TO
cord-017640-i8h48ny6	120	9	prevent	prevent	VB
cord-017640-i8h48ny6	120	10	the	the	DT
cord-017640-i8h48ny6	120	11	aggregation	aggregation	NN
cord-017640-i8h48ny6	120	12	of	of	IN
cord-017640-i8h48ny6	120	13	CD95	CD95	NNP
cord-017640-i8h48ny6	120	14	[	[	-LRB-
cord-017640-i8h48ny6	120	15	89	89	CD
cord-017640-i8h48ny6	120	16	]	]	-RRB-
cord-017640-i8h48ny6	120	17	,	,	,
cord-017640-i8h48ny6	120	18	probably	probably	RB
cord-017640-i8h48ny6	120	19	by	by	IN
cord-017640-i8h48ny6	120	20	retaining	retain	VBG
cord-017640-i8h48ny6	120	21	the	the	DT
cord-017640-i8h48ny6	120	22	receptor	receptor	NN
cord-017640-i8h48ny6	120	23	outside	outside	IN
cord-017640-i8h48ny6	120	24	of	of	IN
cord-017640-i8h48ny6	120	25	lipid	lipid	NN
cord-017640-i8h48ny6	120	26	rafts	raft	NNS
cord-017640-i8h48ny6	120	27	[	[	-LRB-
cord-017640-i8h48ny6	120	28	87	87	CD
cord-017640-i8h48ny6	120	29	,	,	,
cord-017640-i8h48ny6	120	30	90	90	CD
cord-017640-i8h48ny6	120	31	]	]	-RRB-
cord-017640-i8h48ny6	120	32	.	.	.
cord-017640-i8h48ny6	121	1	PEA-15	PEA-15	NNP
cord-017640-i8h48ny6	121	2	,	,	,
cord-017640-i8h48ny6	121	3	also	also	RB
cord-017640-i8h48ny6	121	4	known	know	VBN
cord-017640-i8h48ny6	121	5	as	as	IN
cord-017640-i8h48ny6	121	6	PED	PED	NNP
cord-017640-i8h48ny6	121	7	,	,	,
cord-017640-i8h48ny6	121	8	is	be	VBZ
cord-017640-i8h48ny6	121	9	a	a	DT
cord-017640-i8h48ny6	121	10	protein	protein	NN
cord-017640-i8h48ny6	121	11	containing	contain	VBG
cord-017640-i8h48ny6	121	12	a	a	DT
cord-017640-i8h48ny6	121	13	death	death	NN
cord-017640-i8h48ny6	121	14	effector	effector	NN
cord-017640-i8h48ny6	121	15	domain	domain	NN
cord-017640-i8h48ny6	121	16	(	(	-LRB-
cord-017640-i8h48ny6	121	17	DED	DED	NNP
cord-017640-i8h48ny6	121	18	)	)	-RRB-
cord-017640-i8h48ny6	121	19	that	that	WDT
cord-017640-i8h48ny6	121	20	has	have	VBZ
cord-017640-i8h48ny6	121	21	been	be	VBN
cord-017640-i8h48ny6	121	22	shown	show	VBN
cord-017640-i8h48ny6	121	23	to	to	TO
cord-017640-i8h48ny6	121	24	inhibit	inhibit	VB
cord-017640-i8h48ny6	121	25	the	the	DT
cord-017640-i8h48ny6	121	26	CD95	CD95	NNP
cord-017640-i8h48ny6	121	27	and	and	CC
cord-017640-i8h48ny6	121	28	TNFR1	TNFR1	NNP
cord-017640-i8h48ny6	121	29	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	121	30	signals	signal	NNS
cord-017640-i8h48ny6	121	31	(	(	-LRB-
cord-017640-i8h48ny6	122	1	Fig	Fig	NNP
cord-017640-i8h48ny6	122	2	.	.	.
cord-017640-i8h48ny6	123	1	11	11	CD
cord-017640-i8h48ny6	123	2	.2	.2	CD
cord-017640-i8h48ny6	123	3	)	)	-RRB-
cord-017640-i8h48ny6	123	4	[	[	-LRB-
cord-017640-i8h48ny6	123	5	74	74	CD
cord-017640-i8h48ny6	123	6	]	]	-RRB-
cord-017640-i8h48ny6	123	7	.	.	.
cord-017640-i8h48ny6	124	1	Activation	activation	NN
cord-017640-i8h48ny6	124	2	of	of	IN
cord-017640-i8h48ny6	124	3	PI3	PI3	NNP
cord-017640-i8h48ny6	124	4	K	K	NNP
cord-017640-i8h48ny6	124	5	and	and	CC
cord-017640-i8h48ny6	124	6	its	-PRON-	PRP$
cord-017640-i8h48ny6	124	7	downstream	downstream	JJ
cord-017640-i8h48ny6	124	8	effector	effector	NN
cord-017640-i8h48ny6	124	9	,	,	,
cord-017640-i8h48ny6	124	10	serine	serine	NN
cord-017640-i8h48ny6	124	11	-	-	HYPH
cord-017640-i8h48ny6	124	12	threonine	threonine	NN
cord-017640-i8h48ny6	124	13	kinase	kinase	NN
cord-017640-i8h48ny6	124	14	Akt	Akt	NNP
cord-017640-i8h48ny6	124	15	,	,	,
cord-017640-i8h48ny6	124	16	leads	lead	VBZ
cord-017640-i8h48ny6	124	17	to	to	IN
cord-017640-i8h48ny6	124	18	phosphorylation	phosphorylation	NN
cord-017640-i8h48ny6	124	19	of	of	IN
cord-017640-i8h48ny6	124	20	PEA-15	PEA-15	NNP
cord-017640-i8h48ny6	124	21	at	at	IN
cord-017640-i8h48ny6	124	22	serine	serine	NN
cord-017640-i8h48ny6	124	23	116	116	CD
cord-017640-i8h48ny6	124	24	[	[	-LRB-
cord-017640-i8h48ny6	124	25	87	87	CD
cord-017640-i8h48ny6	124	26	,	,	,
cord-017640-i8h48ny6	124	27	90	90	CD
cord-017640-i8h48ny6	124	28	]	]	-RRB-
cord-017640-i8h48ny6	124	29	;	;	:
cord-017640-i8h48ny6	124	30	this	this	DT
cord-017640-i8h48ny6	124	31	posttranslational	posttranslational	JJ
cord-017640-i8h48ny6	124	32	modification	modification	NN
cord-017640-i8h48ny6	124	33	promotes	promote	VBZ
cord-017640-i8h48ny6	124	34	its	-PRON-	PRP$
cord-017640-i8h48ny6	124	35	interaction	interaction	NN
cord-017640-i8h48ny6	124	36	with	with	IN
cord-017640-i8h48ny6	124	37	FADD	FADD	NNP
cord-017640-i8h48ny6	124	38	,	,	,
cord-017640-i8h48ny6	124	39	ultimately	ultimately	RB
cord-017640-i8h48ny6	124	40	inhibiting	inhibit	VBG
cord-017640-i8h48ny6	124	41	DISC	disc	NN
cord-017640-i8h48ny6	124	42	formation	formation	NN
cord-017640-i8h48ny6	124	43	[	[	-LRB-
cord-017640-i8h48ny6	124	44	91	91	CD
cord-017640-i8h48ny6	124	45	,	,	,
cord-017640-i8h48ny6	124	46	92	92	CD
cord-017640-i8h48ny6	124	47	]	]	-RRB-
cord-017640-i8h48ny6	124	48	.	.	.
cord-017640-i8h48ny6	125	1	Notably	notably	RB
cord-017640-i8h48ny6	125	2	,	,	,
cord-017640-i8h48ny6	125	3	the	the	DT
cord-017640-i8h48ny6	125	4	existence	existence	NN
cord-017640-i8h48ny6	125	5	of	of	IN
cord-017640-i8h48ny6	125	6	type	type	NN
cord-017640-i8h48ny6	125	7	I	-PRON-	PRP
cord-017640-i8h48ny6	125	8	and	and	CC
cord-017640-i8h48ny6	125	9	type	type	NN
cord-017640-i8h48ny6	125	10	II	ii	CD
cord-017640-i8h48ny6	125	11	cells	cell	NNS
cord-017640-i8h48ny6	125	12	is	be	VBZ
cord-017640-i8h48ny6	125	13	not	not	RB
cord-017640-i8h48ny6	125	14	only	only	RB
cord-017640-i8h48ny6	125	15	an	an	DT
cord-017640-i8h48ny6	125	16	in	in	IN
cord-017640-i8h48ny6	125	17	vitro	vitro	FW
cord-017640-i8h48ny6	125	18	observation	observation	NN
cord-017640-i8h48ny6	125	19	,	,	,
cord-017640-i8h48ny6	125	20	but	but	CC
cord-017640-i8h48ny6	125	21	has	have	VBZ
cord-017640-i8h48ny6	125	22	been	be	VBN
cord-017640-i8h48ny6	125	23	identified	identify	VBN
cord-017640-i8h48ny6	125	24	physiologically	physiologically	RB
cord-017640-i8h48ny6	125	25	in	in	IN
cord-017640-i8h48ny6	125	26	the	the	DT
cord-017640-i8h48ny6	125	27	human	human	JJ
cord-017640-i8h48ny6	125	28	body	body	NN
cord-017640-i8h48ny6	125	29	.	.	.
cord-017640-i8h48ny6	126	1	CD95-mediated	cd95-mediated	CD
cord-017640-i8h48ny6	126	2	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	126	3	signal	signal	NN
cord-017640-i8h48ny6	126	4	can	can	MD
cord-017640-i8h48ny6	126	5	not	not	RB
cord-017640-i8h48ny6	126	6	be	be	VB
cord-017640-i8h48ny6	126	7	altered	alter	VBN
cord-017640-i8h48ny6	126	8	in	in	IN
cord-017640-i8h48ny6	126	9	thymocytes	thymocyte	NNS
cord-017640-i8h48ny6	126	10	or	or	CC
cord-017640-i8h48ny6	126	11	activated	activate	VBN
cord-017640-i8h48ny6	126	12	T	T	NNP
cord-017640-i8h48ny6	126	13	-	-	HYPH
cord-017640-i8h48ny6	126	14	cells	cell	NNS
cord-017640-i8h48ny6	126	15	expressing	express	VBG
cord-017640-i8h48ny6	126	16	a	a	DT
cord-017640-i8h48ny6	126	17	Bcl-2	Bcl-2	NNP
cord-017640-i8h48ny6	126	18	transgene	transgene	NN
cord-017640-i8h48ny6	126	19	,	,	,
cord-017640-i8h48ny6	126	20	conferring	confer	VBG
cord-017640-i8h48ny6	126	21	to	to	IN
cord-017640-i8h48ny6	126	22	their	-PRON-	PRP$
cord-017640-i8h48ny6	126	23	type	type	NN
cord-017640-i8h48ny6	126	24	I	-PRON-	PRP
cord-017640-i8h48ny6	126	25	nature	nature	VBP
cord-017640-i8h48ny6	126	26	[	[	-LRB-
cord-017640-i8h48ny6	126	27	93	93	CD
cord-017640-i8h48ny6	126	28	]	]	-RRB-
cord-017640-i8h48ny6	126	29	,	,	,
cord-017640-i8h48ny6	126	30	whereas	whereas	IN
cord-017640-i8h48ny6	126	31	hepatocytes	hepatocyte	NNS
cord-017640-i8h48ny6	126	32	expressing	express	VBG
cord-017640-i8h48ny6	126	33	the	the	DT
cord-017640-i8h48ny6	126	34	same	same	JJ
cord-017640-i8h48ny6	126	35	transgene	transgene	NN
cord-017640-i8h48ny6	126	36	resist	resist	NN
cord-017640-i8h48ny6	126	37	CD95-induced	cd95-induced	CD
cord-017640-i8h48ny6	126	38	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	126	39	and	and	CC
cord-017640-i8h48ny6	126	40	thus	thus	RB
cord-017640-i8h48ny6	126	41	behave	behave	VB
cord-017640-i8h48ny6	126	42	as	as	IN
cord-017640-i8h48ny6	126	43	type	type	NN
cord-017640-i8h48ny6	126	44	II	ii	CD
cord-017640-i8h48ny6	126	45	cells	cell	NNS
cord-017640-i8h48ny6	126	46	[	[	-LRB-
cord-017640-i8h48ny6	126	47	94	94	CD
cord-017640-i8h48ny6	126	48	,	,	,
cord-017640-i8h48ny6	126	49	95	95	CD
cord-017640-i8h48ny6	126	50	]	]	-RRB-
cord-017640-i8h48ny6	126	51	.	.	.
cord-017640-i8h48ny6	127	1	Mutations	mutation	NNS
cord-017640-i8h48ny6	127	2	?	?	.
cord-017640-i8h48ny6	128	1	Germinal	germinal	JJ
cord-017640-i8h48ny6	128	2	mutations	mutation	NNS
cord-017640-i8h48ny6	128	3	in	in	IN
cord-017640-i8h48ny6	128	4	APT-1	APT-1	NNP
cord-017640-i8h48ny6	128	5	have	have	VBP
cord-017640-i8h48ny6	128	6	been	be	VBN
cord-017640-i8h48ny6	128	7	reported	report	VBN
cord-017640-i8h48ny6	128	8	in	in	IN
cord-017640-i8h48ny6	128	9	patients	patient	NNS
cord-017640-i8h48ny6	128	10	developing	develop	VBG
cord-017640-i8h48ny6	128	11	a	a	DT
cord-017640-i8h48ny6	128	12	syndrome	syndrome	NN
cord-017640-i8h48ny6	128	13	termed	term	VBN
cord-017640-i8h48ny6	128	14	autoimmune	autoimmune	JJ
cord-017640-i8h48ny6	128	15	lymphoproliferative	lymphoproliferative	JJ
cord-017640-i8h48ny6	128	16	syndrome	syndrome	NN
cord-017640-i8h48ny6	128	17	type	type	NN
cord-017640-i8h48ny6	128	18	Ia	Ia	NNP
cord-017640-i8h48ny6	128	19	(	(	-LRB-
cord-017640-i8h48ny6	128	20	ALPS	ALPS	NNP
cord-017640-i8h48ny6	128	21	,	,	,
cord-017640-i8h48ny6	128	22	also	also	RB
cord-017640-i8h48ny6	128	23	called	call	VBN
cord-017640-i8h48ny6	128	24	Canale	Canale	NNP
cord-017640-i8h48ny6	128	25	-	-	HYPH
cord-017640-i8h48ny6	128	26	Smith	Smith	NNP
cord-017640-i8h48ny6	128	27	syndrome	syndrome	NN
cord-017640-i8h48ny6	128	28	)	)	-RRB-
cord-017640-i8h48ny6	128	29	[	[	-LRB-
cord-017640-i8h48ny6	128	30	96	96	CD
cord-017640-i8h48ny6	128	31	]	]	-RRB-
cord-017640-i8h48ny6	128	32	[	[	-LRB-
cord-017640-i8h48ny6	128	33	97	97	CD
cord-017640-i8h48ny6	128	34	]	]	-RRB-
cord-017640-i8h48ny6	128	35	[	[	-LRB-
cord-017640-i8h48ny6	128	36	98	98	CD
cord-017640-i8h48ny6	128	37	]	]	-RRB-
cord-017640-i8h48ny6	128	38	.	.	.
cord-017640-i8h48ny6	129	1	ALPS	ALPS	NNP
cord-017640-i8h48ny6	129	2	patients	patient	NNS
cord-017640-i8h48ny6	129	3	show	show	VBP
cord-017640-i8h48ny6	129	4	chronic	chronic	JJ
cord-017640-i8h48ny6	129	5	lymphadenopathy	lymphadenopathy	NN
cord-017640-i8h48ny6	129	6	and	and	CC
cord-017640-i8h48ny6	129	7	splenomegaly	splenomegaly	NN
cord-017640-i8h48ny6	129	8	,	,	,
cord-017640-i8h48ny6	129	9	expanded	expand	VBN
cord-017640-i8h48ny6	129	10	populations	population	NNS
cord-017640-i8h48ny6	129	11	of	of	IN
cord-017640-i8h48ny6	129	12	double	double	JJ
cord-017640-i8h48ny6	129	13	-	-	HYPH
cord-017640-i8h48ny6	129	14	negative	negative	JJ
cord-017640-i8h48ny6	129	15	α	α	NN
cord-017640-i8h48ny6	129	16	/	/	SYM
cord-017640-i8h48ny6	129	17	β	β	NN
cord-017640-i8h48ny6	129	18	-	-	HYPH
cord-017640-i8h48ny6	129	19	Τ	τ	NN
cord-017640-i8h48ny6	129	20	-	-	HYPH
cord-017640-i8h48ny6	129	21	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	129	22	(	(	-LRB-
cord-017640-i8h48ny6	129	23	CD3	CD3	NNP
cord-017640-i8h48ny6	129	24	+	+	SYM
cord-017640-i8h48ny6	129	25	CD4	CD4	NNP
cord-017640-i8h48ny6	129	26	−	−	NNP
cord-017640-i8h48ny6	129	27	CD8	CD8	NNP
cord-017640-i8h48ny6	129	28	−	−	NNP
cord-017640-i8h48ny6	129	29	)	)	-RRB-
cord-017640-i8h48ny6	129	30	,	,	,
cord-017640-i8h48ny6	129	31	and	and	CC
cord-017640-i8h48ny6	129	32	often	often	RB
cord-017640-i8h48ny6	129	33	develop	develop	VBP
cord-017640-i8h48ny6	129	34	autoimmunity	autoimmunity	NN
cord-017640-i8h48ny6	129	35	[	[	-LRB-
cord-017640-i8h48ny6	129	36	96	96	CD
cord-017640-i8h48ny6	129	37	,	,	,
cord-017640-i8h48ny6	129	38	97	97	CD
cord-017640-i8h48ny6	129	39	,	,	,
cord-017640-i8h48ny6	129	40	99	99	CD
cord-017640-i8h48ny6	129	41	,	,	,
cord-017640-i8h48ny6	129	42	100	100	CD
cord-017640-i8h48ny6	129	43	]	]	-RRB-
cord-017640-i8h48ny6	129	44	.	.	.
cord-017640-i8h48ny6	130	1	In	in	IN
cord-017640-i8h48ny6	130	2	agreement	agreement	NN
cord-017640-i8h48ny6	130	3	with	with	IN
cord-017640-i8h48ny6	130	4	the	the	DT
cord-017640-i8h48ny6	130	5	notion	notion	NN
cord-017640-i8h48ny6	130	6	that	that	IN
cord-017640-i8h48ny6	130	7	CD95	CD95	NNP
cord-017640-i8h48ny6	130	8	behaves	behave	VBZ
cord-017640-i8h48ny6	130	9	as	as	IN
cord-017640-i8h48ny6	130	10	a	a	DT
cord-017640-i8h48ny6	130	11	tumor	tumor	NN
cord-017640-i8h48ny6	130	12	suppressor	suppressor	NN
cord-017640-i8h48ny6	130	13	,	,	,
cord-017640-i8h48ny6	130	14	ALPS	ALPS	NNP
cord-017640-i8h48ny6	130	15	patients	patient	NNS
cord-017640-i8h48ny6	130	16	display	display	VBP
cord-017640-i8h48ny6	130	17	an	an	DT
cord-017640-i8h48ny6	130	18	increased	increase	VBN
cord-017640-i8h48ny6	130	19	risk	risk	NN
cord-017640-i8h48ny6	130	20	of	of	IN
cord-017640-i8h48ny6	130	21	Hodgkin	Hodgkin	NNP
cord-017640-i8h48ny6	130	22	and	and	CC
cord-017640-i8h48ny6	130	23	non	non	JJ
cord-017640-i8h48ny6	130	24	-	-	JJ
cord-017640-i8h48ny6	130	25	Hodgkin	Hodgkin	NNP
cord-017640-i8h48ny6	130	26	lymphoma	lymphoma	NN
cord-017640-i8h48ny6	130	27	[	[	-LRB-
cord-017640-i8h48ny6	130	28	101	101	CD
cord-017640-i8h48ny6	130	29	]	]	-RRB-
cord-017640-i8h48ny6	130	30	.	.	.
cord-017640-i8h48ny6	131	1	Predominance	predominance	NN
cord-017640-i8h48ny6	131	2	of	of	IN
cord-017640-i8h48ny6	131	3	post	post	JJ
cord-017640-i8h48ny6	131	4	-	-	JJ
cord-017640-i8h48ny6	131	5	germinal	germinal	JJ
cord-017640-i8h48ny6	131	6	center	center	NN
cord-017640-i8h48ny6	131	7	(	(	-LRB-
cord-017640-i8h48ny6	131	8	GC	GC	NNP
cord-017640-i8h48ny6	131	9	)	)	-RRB-
cord-017640-i8h48ny6	131	10	lymphomas	lymphoma	NNS
cord-017640-i8h48ny6	131	11	in	in	IN
cord-017640-i8h48ny6	131	12	patients	patient	NNS
cord-017640-i8h48ny6	131	13	exhibiting	exhibit	VBG
cord-017640-i8h48ny6	131	14	either	either	CC
cord-017640-i8h48ny6	131	15	germ	germ	NN
cord-017640-i8h48ny6	131	16	line	line	NN
cord-017640-i8h48ny6	131	17	or	or	CC
cord-017640-i8h48ny6	131	18	somatic	somatic	JJ
cord-017640-i8h48ny6	131	19	CD95	CD95	NNP
cord-017640-i8h48ny6	131	20	mutations	mutation	NNS
cord-017640-i8h48ny6	131	21	can	can	MD
cord-017640-i8h48ny6	131	22	be	be	VB
cord-017640-i8h48ny6	131	23	explained	explain	VBN
cord-017640-i8h48ny6	131	24	by	by	IN
cord-017640-i8h48ny6	131	25	the	the	DT
cord-017640-i8h48ny6	131	26	fact	fact	NN
cord-017640-i8h48ny6	131	27	that	that	IN
cord-017640-i8h48ny6	131	28	,	,	,
cord-017640-i8h48ny6	131	29	inside	inside	IN
cord-017640-i8h48ny6	131	30	germinal	germinal	JJ
cord-017640-i8h48ny6	131	31	centers	center	NNS
cord-017640-i8h48ny6	131	32	of	of	IN
cord-017640-i8h48ny6	131	33	the	the	DT
cord-017640-i8h48ny6	131	34	secondary	secondary	JJ
cord-017640-i8h48ny6	131	35	lymphoid	lymphoid	JJ
cord-017640-i8h48ny6	131	36	follicles	follicle	NNS
cord-017640-i8h48ny6	131	37	,	,	,
cord-017640-i8h48ny6	131	38	the	the	DT
cord-017640-i8h48ny6	131	39	CD95	CD95	NNP
cord-017640-i8h48ny6	131	40	signal	signal	NN
cord-017640-i8h48ny6	131	41	plays	play	VBZ
cord-017640-i8h48ny6	131	42	a	a	DT
cord-017640-i8h48ny6	131	43	pivotal	pivotal	JJ
cord-017640-i8h48ny6	131	44	role	role	NN
cord-017640-i8h48ny6	131	45	in	in	IN
cord-017640-i8h48ny6	131	46	the	the	DT
cord-017640-i8h48ny6	131	47	deletion	deletion	NN
cord-017640-i8h48ny6	131	48	of	of	IN
cord-017640-i8h48ny6	131	49	self	self	NN
cord-017640-i8h48ny6	131	50	-	-	HYPH
cord-017640-i8h48ny6	131	51	reactive	reactive	JJ
cord-017640-i8h48ny6	131	52	maturating	maturating	NN
cord-017640-i8h48ny6	131	53	B	b	NN
cord-017640-i8h48ny6	131	54	-	-	HYPH
cord-017640-i8h48ny6	131	55	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	131	56	[	[	-LRB-
cord-017640-i8h48ny6	131	57	102	102	CD
cord-017640-i8h48ny6	131	58	]	]	-RRB-
cord-017640-i8h48ny6	131	59	,	,	,
cord-017640-i8h48ny6	131	60	in	in	IN
cord-017640-i8h48ny6	131	61	addition	addition	NN
cord-017640-i8h48ny6	131	62	to	to	IN
cord-017640-i8h48ny6	131	63	the	the	DT
cord-017640-i8h48ny6	131	64	fact	fact	NN
cord-017640-i8h48ny6	131	65	that	that	IN
cord-017640-i8h48ny6	131	66	APT-1	APT-1	NNP
cord-017640-i8h48ny6	131	67	belongs	belong	VBZ
cord-017640-i8h48ny6	131	68	to	to	IN
cord-017640-i8h48ny6	131	69	a	a	DT
cord-017640-i8h48ny6	131	70	set	set	NN
cord-017640-i8h48ny6	131	71	of	of	IN
cord-017640-i8h48ny6	131	72	rare	rare	JJ
cord-017640-i8h48ny6	131	73	genes	gene	NNS
cord-017640-i8h48ny6	131	74	(	(	-LRB-
cord-017640-i8h48ny6	131	75	i.e.	i.e.	FW
cord-017640-i8h48ny6	131	76	,	,	,
cord-017640-i8h48ny6	131	77	PIM1	PIM1	NNP
cord-017640-i8h48ny6	131	78	,	,	,
cord-017640-i8h48ny6	131	79	c	c	NNP
cord-017640-i8h48ny6	131	80	-	-	HYPH
cord-017640-i8h48ny6	131	81	myc	myc	NNP
cord-017640-i8h48ny6	131	82	,	,	,
cord-017640-i8h48ny6	131	83	PAX5	PAX5	NNP
cord-017640-i8h48ny6	131	84	,	,	,
cord-017640-i8h48ny6	131	85	RhoH	RhoH	NNP
cord-017640-i8h48ny6	131	86	/	/	SYM
cord-017640-i8h48ny6	131	87	TTF	TTF	NNP
cord-017640-i8h48ny6	131	88	,	,	,
cord-017640-i8h48ny6	131	89	and	and	CC
cord-017640-i8h48ny6	131	90	Bcl-6	Bcl-6	NNP
cord-017640-i8h48ny6	131	91	)	)	-RRB-
cord-017640-i8h48ny6	131	92	subject	subject	JJ
cord-017640-i8h48ny6	131	93	to	to	IN
cord-017640-i8h48ny6	131	94	somatic	somatic	JJ
cord-017640-i8h48ny6	131	95	hypermutation	hypermutation	NN
cord-017640-i8h48ny6	131	96	[	[	-LRB-
cord-017640-i8h48ny6	131	97	103	103	CD
cord-017640-i8h48ny6	131	98	,	,	,
cord-017640-i8h48ny6	131	99	104	104	CD
cord-017640-i8h48ny6	131	100	]	]	-RRB-
cord-017640-i8h48ny6	131	101	,	,	,
cord-017640-i8h48ny6	131	102	which	which	WDT
cord-017640-i8h48ny6	131	103	may	may	MD
cord-017640-i8h48ny6	131	104	affect	affect	VB
cord-017640-i8h48ny6	131	105	biological	biological	JJ
cord-017640-i8h48ny6	131	106	function	function	NN
cord-017640-i8h48ny6	131	107	.	.	.
cord-017640-i8h48ny6	132	1	In	in	IN
cord-017640-i8h48ny6	132	2	addition	addition	NN
cord-017640-i8h48ny6	132	3	to	to	IN
cord-017640-i8h48ny6	132	4	post	post	VB
cord-017640-i8h48ny6	132	5	-	-	JJ
cord-017640-i8h48ny6	132	6	GC	GC	NNP
cord-017640-i8h48ny6	132	7	lymphomas	lymphoma	NNS
cord-017640-i8h48ny6	132	8	,	,	,
cord-017640-i8h48ny6	132	9	significant	significant	JJ
cord-017640-i8h48ny6	132	10	amounts	amount	NNS
cord-017640-i8h48ny6	132	11	of	of	IN
cord-017640-i8h48ny6	132	12	mutations	mutation	NNS
cord-017640-i8h48ny6	132	13	in	in	IN
cord-017640-i8h48ny6	132	14	the	the	DT
cord-017640-i8h48ny6	132	15	CD95	CD95	NNP
cord-017640-i8h48ny6	132	16	gene	gene	NN
cord-017640-i8h48ny6	132	17	were	be	VBD
cord-017640-i8h48ny6	132	18	found	find	VBN
cord-017640-i8h48ny6	132	19	in	in	IN
cord-017640-i8h48ny6	132	20	tumors	tumor	NNS
cord-017640-i8h48ny6	132	21	of	of	IN
cord-017640-i8h48ny6	132	22	various	various	JJ
cord-017640-i8h48ny6	132	23	histological	histological	JJ
cord-017640-i8h48ny6	132	24	origins	origin	NNS
cord-017640-i8h48ny6	132	25	(	(	-LRB-
cord-017640-i8h48ny6	132	26	reviewed	review	VBN
cord-017640-i8h48ny6	132	27	in	in	IN
cord-017640-i8h48ny6	132	28	[	[	-LRB-
cord-017640-i8h48ny6	132	29	54	54	CD
cord-017640-i8h48ny6	132	30	]	]	-RRB-
cord-017640-i8h48ny6	132	31	)	)	-RRB-
cord-017640-i8h48ny6	132	32	.	.	.
cord-017640-i8h48ny6	133	1	Extensive	extensive	JJ
cord-017640-i8h48ny6	133	2	analysis	analysis	NN
cord-017640-i8h48ny6	133	3	of	of	IN
cord-017640-i8h48ny6	133	4	CD95	CD95	NNP
cord-017640-i8h48ny6	133	5	mutations	mutation	NNS
cord-017640-i8h48ny6	133	6	and	and	CC
cord-017640-i8h48ny6	133	7	their	-PRON-	PRP$
cord-017640-i8h48ny6	133	8	distribution	distribution	NN
cord-017640-i8h48ny6	133	9	in	in	IN
cord-017640-i8h48ny6	133	10	APT-1	APT-1	NNP
cord-017640-i8h48ny6	133	11	reveals	reveal	VBZ
cord-017640-i8h48ny6	133	12	that	that	IN
cord-017640-i8h48ny6	133	13	,	,	,
cord-017640-i8h48ny6	133	14	with	with	IN
cord-017640-i8h48ny6	133	15	some	some	DT
cord-017640-i8h48ny6	133	16	exceptions	exception	NNS
cord-017640-i8h48ny6	133	17	,	,	,
cord-017640-i8h48ny6	133	18	most	most	JJS
cord-017640-i8h48ny6	133	19	are	be	VBP
cord-017640-i8h48ny6	133	20	gathered	gather	VBN
cord-017640-i8h48ny6	133	21	in	in	IN
cord-017640-i8h48ny6	133	22	exons	exon	NNS
cord-017640-i8h48ny6	133	23	8	8	CD
cord-017640-i8h48ny6	133	24	and	and	CC
cord-017640-i8h48ny6	133	25	9	9	CD
cord-017640-i8h48ny6	133	26	encoding	encode	VBG
cord-017640-i8h48ny6	133	27	the	the	DT
cord-017640-i8h48ny6	133	28	CD95	CD95	NNP
cord-017640-i8h48ny6	133	29	intracellular	intracellular	JJ
cord-017640-i8h48ny6	133	30	region	region	NN
cord-017640-i8h48ny6	133	31	(	(	-LRB-
cord-017640-i8h48ny6	133	32	Fig	fig	NN
cord-017640-i8h48ny6	133	33	.	.	.
cord-017640-i8h48ny6	134	1	11	11	CD
cord-017640-i8h48ny6	134	2	.	.	.
cord-017640-i8h48ny6	135	1	3	3	LS
cord-017640-i8h48ny6	135	2	)	)	-RRB-
cord-017640-i8h48ny6	135	3	[	[	-LRB-
cord-017640-i8h48ny6	135	4	105	105	CD
cord-017640-i8h48ny6	135	5	]	]	-RRB-
cord-017640-i8h48ny6	135	6	.	.	.
cord-017640-i8h48ny6	136	1	Remarkably	remarkably	RB
cord-017640-i8h48ny6	136	2	,	,	,
cord-017640-i8h48ny6	136	3	most	most	JJS
cord-017640-i8h48ny6	136	4	of	of	IN
cord-017640-i8h48ny6	136	5	these	these	DT
cord-017640-i8h48ny6	136	6	mutations	mutation	NNS
cord-017640-i8h48ny6	136	7	are	be	VBP
cord-017640-i8h48ny6	136	8	heterozygous	heterozygous	JJ
cord-017640-i8h48ny6	136	9	,	,	,
cord-017640-i8h48ny6	136	10	mainly	mainly	RB
cord-017640-i8h48ny6	136	11	localized	localize	VBN
cord-017640-i8h48ny6	136	12	in	in	IN
cord-017640-i8h48ny6	136	13	CD95-DD	cd95-dd	NN
cord-017640-i8h48ny6	136	14	,	,	,
cord-017640-i8h48ny6	136	15	and	and	CC
cord-017640-i8h48ny6	136	16	lead	lead	VB
cord-017640-i8h48ny6	136	17	to	to	IN
cord-017640-i8h48ny6	136	18	inhibition	inhibition	NN
cord-017640-i8h48ny6	136	19	of	of	IN
cord-017640-i8h48ny6	136	20	the	the	DT
cord-017640-i8h48ny6	136	21	CD95-mediated	cd95-mediated	CD
cord-017640-i8h48ny6	136	22	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	136	23	signal	signal	NN
cord-017640-i8h48ny6	136	24	.	.	.
cord-017640-i8h48ny6	137	1	Indeed	indeed	RB
cord-017640-i8h48ny6	137	2	,	,	,
cord-017640-i8h48ny6	137	3	in	in	IN
cord-017640-i8h48ny6	137	4	agreement	agreement	NN
cord-017640-i8h48ny6	137	5	with	with	IN
cord-017640-i8h48ny6	137	6	the	the	DT
cord-017640-i8h48ny6	137	7	notion	notion	NN
cord-017640-i8h48ny6	137	8	that	that	IN
cord-017640-i8h48ny6	137	9	CD95	CD95	NNP
cord-017640-i8h48ny6	137	10	is	be	VBZ
cord-017640-i8h48ny6	137	11	expressed	express	VBN
cord-017640-i8h48ny6	137	12	at	at	IN
cord-017640-i8h48ny6	137	13	the	the	DT
cord-017640-i8h48ny6	137	14	plasma	plasma	NN
cord-017640-i8h48ny6	137	15	membrane	membrane	NN
cord-017640-i8h48ny6	137	16	as	as	IN
cord-017640-i8h48ny6	137	17	a	a	DT
cord-017640-i8h48ny6	137	18	pre	pre	JJ
cord-017640-i8h48ny6	137	19	-	-	JJ
cord-017640-i8h48ny6	137	20	associated	associated	JJ
cord-017640-i8h48ny6	137	21	homotrimer	homotrimer	NNP
cord-017640-i8h48ny6	137	22	[	[	-LRB-
cord-017640-i8h48ny6	137	23	23	23	CD
cord-017640-i8h48ny6	137	24	,	,	,
cord-017640-i8h48ny6	137	25	24	24	CD
cord-017640-i8h48ny6	137	26	]	]	-RRB-
cord-017640-i8h48ny6	137	27	,	,	,
cord-017640-i8h48ny6	137	28	formation	formation	NN
cord-017640-i8h48ny6	137	29	of	of	IN
cord-017640-i8h48ny6	137	30	heterocomplexes	heterocomplexes	JJ
cord-017640-i8h48ny6	137	31	containing	contain	VBG
cord-017640-i8h48ny6	137	32	wild	wild	JJ
cord-017640-i8h48ny6	137	33	-	-	HYPH
cord-017640-i8h48ny6	137	34	type	type	NN
cord-017640-i8h48ny6	137	35	and	and	CC
cord-017640-i8h48ny6	137	36	mutated	mutate	VBN
cord-017640-i8h48ny6	137	37	CD95	CD95	NNP
cord-017640-i8h48ny6	137	38	prevents	prevent	VBZ
cord-017640-i8h48ny6	137	39	FADD	FADD	NNP
cord-017640-i8h48ny6	137	40	recruitment	recruitment	NN
cord-017640-i8h48ny6	137	41	and	and	CC
cord-017640-i8h48ny6	137	42	abrogates	abrogate	VBZ
cord-017640-i8h48ny6	137	43	the	the	DT
cord-017640-i8h48ny6	137	44	ignition	ignition	NN
cord-017640-i8h48ny6	137	45	of	of	IN
cord-017640-i8h48ny6	137	46	the	the	DT
cord-017640-i8h48ny6	137	47	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	137	48	signal	signal	NN
cord-017640-i8h48ny6	137	49	in	in	IN
cord-017640-i8h48ny6	137	50	a	a	DT
cord-017640-i8h48ny6	137	51	dominant	dominant	JJ
cord-017640-i8h48ny6	137	52	manner	manner	NN
cord-017640-i8h48ny6	137	53	.	.	.
cord-017640-i8h48ny6	138	1	Extensive	extensive	JJ
cord-017640-i8h48ny6	138	2	analysis	analysis	NN
cord-017640-i8h48ny6	138	3	and	and	CC
cord-017640-i8h48ny6	138	4	positioning	positioning	NN
cord-017640-i8h48ny6	138	5	of	of	IN
cord-017640-i8h48ny6	138	6	various	various	JJ
cord-017640-i8h48ny6	138	7	CD95	CD95	NNP
cord-017640-i8h48ny6	138	8	mutations	mutation	NNS
cord-017640-i8h48ny6	138	9	described	describe	VBN
cord-017640-i8h48ny6	138	10	in	in	IN
cord-017640-i8h48ny6	138	11	the	the	DT
cord-017640-i8h48ny6	138	12	literature	literature	NN
cord-017640-i8h48ny6	138	13	seem	seem	VBP
cord-017640-i8h48ny6	138	14	to	to	TO
cord-017640-i8h48ny6	138	15	highlight	highlight	VB
cord-017640-i8h48ny6	138	16	mutation	mutation	NN
cord-017640-i8h48ny6	138	17	"	"	``
cord-017640-i8h48ny6	138	18	hot	hot	JJ
cord-017640-i8h48ny6	138	19	spots	spot	NNS
cord-017640-i8h48ny6	138	20	"	"	''
cord-017640-i8h48ny6	138	21	in	in	IN
cord-017640-i8h48ny6	138	22	the	the	DT
cord-017640-i8h48ny6	138	23	CD95	CD95	NNP
cord-017640-i8h48ny6	138	24	sequence	sequence	NN
cord-017640-i8h48ny6	138	25	(	(	-LRB-
cord-017640-i8h48ny6	138	26	Fig	Fig	NNP
cord-017640-i8h48ny6	138	27	.	.	.
cord-017640-i8h48ny6	138	28	11.3	11.3	CD
cord-017640-i8h48ny6	138	29	)	)	-RRB-
cord-017640-i8h48ny6	138	30	.	.	.
cord-017640-i8h48ny6	139	1	Among	among	IN
cord-017640-i8h48ny6	139	2	these	these	DT
cord-017640-i8h48ny6	139	3	hot	hot	JJ
cord-017640-i8h48ny6	139	4	spots	spot	NNS
cord-017640-i8h48ny6	139	5	,	,	,
cord-017640-i8h48ny6	139	6	arginine	arginine	NN
cord-017640-i8h48ny6	139	7	234	234	CD
cord-017640-i8h48ny6	139	8	,	,	,
cord-017640-i8h48ny6	139	9	aspartic	aspartic	JJ
cord-017640-i8h48ny6	139	10	acid	acid	NN
cord-017640-i8h48ny6	139	11	244	244	CD
cord-017640-i8h48ny6	139	12	,	,	,
cord-017640-i8h48ny6	139	13	and	and	CC
cord-017640-i8h48ny6	139	14	valine	valine	NN
cord-017640-i8h48ny6	139	15	251	251	CD
cord-017640-i8h48ny6	139	16	account	account	NN
cord-017640-i8h48ny6	139	17	for	for	IN
cord-017640-i8h48ny6	139	18	a	a	DT
cord-017640-i8h48ny6	139	19	significant	significant	JJ
cord-017640-i8h48ny6	139	20	amount	amount	NN
cord-017640-i8h48ny6	139	21	of	of	IN
cord-017640-i8h48ny6	139	22	the	the	DT
cord-017640-i8h48ny6	139	23	documented	document	VBN
cord-017640-i8h48ny6	139	24	CD95	CD95	NNP
cord-017640-i8h48ny6	139	25	mutations	mutation	NNS
cord-017640-i8h48ny6	139	26	.	.	.
cord-017640-i8h48ny6	140	1	Indeed	indeed	RB
cord-017640-i8h48ny6	140	2	,	,	,
cord-017640-i8h48ny6	140	3	among	among	IN
cord-017640-i8h48ny6	140	4	the	the	DT
cord-017640-i8h48ny6	140	5	189	189	CD
cord-017640-i8h48ny6	140	6	mutations	mutation	NNS
cord-017640-i8h48ny6	140	7	annotated	annotate	VBN
cord-017640-i8h48ny6	140	8	in	in	IN
cord-017640-i8h48ny6	140	9	the	the	DT
cord-017640-i8h48ny6	140	10	335	335	CD
cord-017640-i8h48ny6	140	11	amino	amino	JJ
cord-017640-i8h48ny6	140	12	acids	acid	NNS
cord-017640-i8h48ny6	140	13	of	of	IN
cord-017640-i8h48ny6	140	14	CD95	CD95	NNP
cord-017640-i8h48ny6	140	15	,	,	,
cord-017640-i8h48ny6	140	16	30	30	CD
cord-017640-i8h48ny6	140	17	(	(	-LRB-
cord-017640-i8h48ny6	140	18	~16	~16	CD
cord-017640-i8h48ny6	140	19	%	%	NN
cord-017640-i8h48ny6	140	20	)	)	-RRB-
cord-017640-i8h48ny6	140	21	are	be	VBP
cord-017640-i8h48ny6	140	22	localized	localize	VBN
cord-017640-i8h48ny6	140	23	on	on	IN
cord-017640-i8h48ny6	140	24	these	these	DT
cord-017640-i8h48ny6	140	25	three	three	CD
cord-017640-i8h48ny6	140	26	amino	amino	NN
cord-017640-i8h48ny6	140	27	acids	acid	NNS
cord-017640-i8h48ny6	140	28	(	(	-LRB-
cord-017640-i8h48ny6	140	29	Fig	Fig	NNP
cord-017640-i8h48ny6	140	30	.	.	.
cord-017640-i8h48ny6	140	31	11.3	11.3	CD
cord-017640-i8h48ny6	140	32	)	)	-RRB-
cord-017640-i8h48ny6	140	33	.	.	.
cord-017640-i8h48ny6	141	1	Strikingly	strikingly	RB
cord-017640-i8h48ny6	141	2	,	,	,
cord-017640-i8h48ny6	141	3	the	the	DT
cord-017640-i8h48ny6	141	4	pivotal	pivotal	JJ
cord-017640-i8h48ny6	141	5	role	role	NN
cord-017640-i8h48ny6	141	6	played	play	VBN
cord-017640-i8h48ny6	141	7	by	by	IN
cord-017640-i8h48ny6	141	8	these	these	DT
cord-017640-i8h48ny6	141	9	amino	amino	NN
cord-017640-i8h48ny6	141	10	acids	acid	NNS
cord-017640-i8h48ny6	141	11	in	in	IN
cord-017640-i8h48ny6	141	12	stabilization	stabilization	NN
cord-017640-i8h48ny6	141	13	or	or	CC
cord-017640-i8h48ny6	141	14	formation	formation	NN
cord-017640-i8h48ny6	141	15	of	of	IN
cord-017640-i8h48ny6	141	16	intra	intra	JJ
cord-017640-i8h48ny6	141	17	-	-	JJ
cord-017640-i8h48ny6	141	18	and	and	CC
cord-017640-i8h48ny6	141	19	interbridges	interbridge	NNS
cord-017640-i8h48ny6	141	20	between	between	IN
cord-017640-i8h48ny6	141	21	CD95	CD95	NNP
cord-017640-i8h48ny6	141	22	and	and	CC
cord-017640-i8h48ny6	141	23	FADD	FADD	NNP
cord-017640-i8h48ny6	141	24	may	may	MD
cord-017640-i8h48ny6	141	25	explain	explain	VB
cord-017640-i8h48ny6	141	26	these	these	DT
cord-017640-i8h48ny6	141	27	hot	hot	JJ
cord-017640-i8h48ny6	141	28	spots	spot	NNS
cord-017640-i8h48ny6	141	29	.	.	.
cord-017640-i8h48ny6	142	1	For	for	IN
cord-017640-i8h48ny6	142	2	instance	instance	NN
cord-017640-i8h48ny6	142	3	,	,	,
cord-017640-i8h48ny6	142	4	both	both	CC
cord-017640-i8h48ny6	142	5	R234	r234	RB
cord-017640-i8h48ny6	142	6	and	and	CC
cord-017640-i8h48ny6	142	7	D244	D244	NNPS
cord-017640-i8h48ny6	142	8	contribute	contribute	VB
cord-017640-i8h48ny6	142	9	to	to	IN
cord-017640-i8h48ny6	142	10	the	the	DT
cord-017640-i8h48ny6	142	11	homotypic	homotypic	JJ
cord-017640-i8h48ny6	142	12	aggregation	aggregation	NN
cord-017640-i8h48ny6	142	13	of	of	IN
cord-017640-i8h48ny6	142	14	the	the	DT
cord-017640-i8h48ny6	142	15	receptor	receptor	NN
cord-017640-i8h48ny6	142	16	and	and	CC
cord-017640-i8h48ny6	142	17	FADD	FADD	NNP
cord-017640-i8h48ny6	142	18	recruitment	recruitment	NN
cord-017640-i8h48ny6	142	19	[	[	-LRB-
cord-017640-i8h48ny6	142	20	67	67	CD
cord-017640-i8h48ny6	142	21	]	]	-RRB-
cord-017640-i8h48ny6	142	22	.	.	.
cord-017640-i8h48ny6	143	1	Nevertheless	nevertheless	RB
cord-017640-i8h48ny6	143	2	,	,	,
cord-017640-i8h48ny6	143	3	the	the	DT
cord-017640-i8h48ny6	143	4	observation	observation	NN
cord-017640-i8h48ny6	143	5	of	of	IN
cord-017640-i8h48ny6	143	6	death	death	NN
cord-017640-i8h48ny6	143	7	domain	domain	NN
cord-017640-i8h48ny6	143	8	hot	hot	JJ
cord-017640-i8h48ny6	143	9	spots	spot	NNS
cord-017640-i8h48ny6	143	10	is	be	VBZ
cord-017640-i8h48ny6	143	11	in	in	IN
cord-017640-i8h48ny6	143	12	contradiction	contradiction	NN
cord-017640-i8h48ny6	143	13	with	with	IN
cord-017640-i8h48ny6	143	14	the	the	DT
cord-017640-i8h48ny6	143	15	study	study	NN
cord-017640-i8h48ny6	143	16	of	of	IN
cord-017640-i8h48ny6	143	17	Scott	Scott	NNP
cord-017640-i8h48ny6	143	18	and	and	CC
cord-017640-i8h48ny6	143	19	colleagues	colleague	NNS
cord-017640-i8h48ny6	143	20	demonstrating	demonstrate	VBG
cord-017640-i8h48ny6	143	21	that	that	IN
cord-017640-i8h48ny6	143	22	the	the	DT
cord-017640-i8h48ny6	143	23	region	region	NN
cord-017640-i8h48ny6	143	24	of	of	IN
cord-017640-i8h48ny6	143	25	the	the	DT
cord-017640-i8h48ny6	143	26	CD95-DD	cd95-dd	NN
cord-017640-i8h48ny6	143	27	interacting	interact	VBG
cord-017640-i8h48ny6	143	28	with	with	IN
cord-017640-i8h48ny6	143	29	the	the	DT
cord-017640-i8h48ny6	143	30	FADD	FADD	NNP
cord-017640-i8h48ny6	143	31	-	-	HYPH
cord-017640-i8h48ny6	143	32	DD	DD	NNP
cord-017640-i8h48ny6	143	33	extends	extend	VBZ
cord-017640-i8h48ny6	143	34	over	over	RP
cord-017640-i8h48ny6	143	35	a	a	DT
cord-017640-i8h48ny6	143	36	disperse	disperse	NN
cord-017640-i8h48ny6	143	37	surface	surface	NN
cord-017640-i8h48ny6	143	38	through	through	IN
cord-017640-i8h48ny6	143	39	weak	weak	JJ
cord-017640-i8h48ny6	143	40	binding	bind	VBG
cord-017640-i8h48ny6	143	41	affinity	affinity	NN
cord-017640-i8h48ny6	143	42	[	[	-LRB-
cord-017640-i8h48ny6	143	43	68	68	CD
cord-017640-i8h48ny6	143	44	]	]	-RRB-
cord-017640-i8h48ny6	143	45	.	.	.
cord-017640-i8h48ny6	144	1	Most	Most	JJS
cord-017640-i8h48ny6	144	2	ALPS	ALPS	NNP
cord-017640-i8h48ny6	144	3	type	type	NN
cord-017640-i8h48ny6	144	4	Ia	Ia	NNP
cord-017640-i8h48ny6	144	5	patients	patient	NNS
cord-017640-i8h48ny6	144	6	affected	affect	VBN
cord-017640-i8h48ny6	144	7	by	by	IN
cord-017640-i8h48ny6	144	8	malignancies	malignancy	NNS
cord-017640-i8h48ny6	144	9	do	do	VBP
cord-017640-i8h48ny6	144	10	not	not	RB
cord-017640-i8h48ny6	144	11	undergo	undergo	VB
cord-017640-i8h48ny6	144	12	loss	loss	NN
cord-017640-i8h48ny6	144	13	of	of	IN
cord-017640-i8h48ny6	144	14	heterozygosity	heterozygosity	NN
cord-017640-i8h48ny6	144	15	(	(	-LRB-
cord-017640-i8h48ny6	144	16	LOH	LOH	NNP
cord-017640-i8h48ny6	144	17	)	)	-RRB-
cord-017640-i8h48ny6	144	18	,	,	,
cord-017640-i8h48ny6	144	19	which	which	WDT
cord-017640-i8h48ny6	144	20	formed	form	VBD
cord-017640-i8h48ny6	144	21	the	the	DT
cord-017640-i8h48ny6	144	22	hypothesis	hypothesis	NN
cord-017640-i8h48ny6	144	23	that	that	IN
cord-017640-i8h48ny6	144	24	preservation	preservation	NN
cord-017640-i8h48ny6	144	25	of	of	IN
cord-017640-i8h48ny6	144	26	a	a	DT
cord-017640-i8h48ny6	144	27	wild	wild	JJ
cord-017640-i8h48ny6	144	28	-	-	HYPH
cord-017640-i8h48ny6	144	29	type	type	NN
cord-017640-i8h48ny6	144	30	allele	allele	NN
cord-017640-i8h48ny6	144	31	may	may	MD
cord-017640-i8h48ny6	144	32	contribute	contribute	VB
cord-017640-i8h48ny6	144	33	to	to	IN
cord-017640-i8h48ny6	144	34	carcinogenesis	carcinogenesis	NN
cord-017640-i8h48ny6	144	35	[	[	-LRB-
cord-017640-i8h48ny6	144	36	106	106	CD
cord-017640-i8h48ny6	144	37	,	,	,
cord-017640-i8h48ny6	144	38	107	107	CD
cord-017640-i8h48ny6	144	39	]	]	-RRB-
cord-017640-i8h48ny6	144	40	.	.	.
cord-017640-i8h48ny6	145	1	In	in	IN
cord-017640-i8h48ny6	145	2	the	the	DT
cord-017640-i8h48ny6	145	3	same	same	JJ
cord-017640-i8h48ny6	145	4	line	line	NN
cord-017640-i8h48ny6	145	5	,	,	,
cord-017640-i8h48ny6	145	6	it	-PRON-	PRP
cord-017640-i8h48ny6	145	7	was	be	VBD
cord-017640-i8h48ny6	145	8	demonstrated	demonstrate	VBN
cord-017640-i8h48ny6	145	9	that	that	IN
cord-017640-i8h48ny6	145	10	expression	expression	NN
cord-017640-i8h48ny6	145	11	of	of	IN
cord-017640-i8h48ny6	145	12	a	a	DT
cord-017640-i8h48ny6	145	13	unique	unique	JJ
cord-017640-i8h48ny6	145	14	mutated	mutate	VBN
cord-017640-i8h48ny6	145	15	CD95	CD95	NNP
cord-017640-i8h48ny6	145	16	allele	allele	NN
cord-017640-i8h48ny6	145	17	blocks	block	VBZ
cord-017640-i8h48ny6	145	18	the	the	DT
cord-017640-i8h48ny6	145	19	induction	induction	NN
cord-017640-i8h48ny6	145	20	of	of	IN
cord-017640-i8h48ny6	145	21	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	145	22	signals	signal	NNS
cord-017640-i8h48ny6	145	23	,	,	,
cord-017640-i8h48ny6	145	24	while	while	IN
cord-017640-i8h48ny6	145	25	it	-PRON-	PRP
cord-017640-i8h48ny6	145	26	fails	fail	VBZ
cord-017640-i8h48ny6	145	27	to	to	TO
cord-017640-i8h48ny6	145	28	prevent	prevent	VB
cord-017640-i8h48ny6	145	29	nonapoptotic	nonapoptotic	JJ
cord-017640-i8h48ny6	145	30	signals	signal	NNS
cord-017640-i8h48ny6	145	31	such	such	JJ
cord-017640-i8h48ny6	145	32	as	as	IN
cord-017640-i8h48ny6	145	33	NF	nf	NN
cord-017640-i8h48ny6	145	34	-	-	HYPH
cord-017640-i8h48ny6	145	35	κB	κB	NNP
cord-017640-i8h48ny6	145	36	and	and	CC
cord-017640-i8h48ny6	145	37	MAPK	MAPK	NNP
cord-017640-i8h48ny6	145	38	[	[	-LRB-
cord-017640-i8h48ny6	145	39	106	106	CD
cord-017640-i8h48ny6	145	40	,	,	,
cord-017640-i8h48ny6	145	41	107	107	CD
cord-017640-i8h48ny6	145	42	]	]	-RRB-
cord-017640-i8h48ny6	145	43	,	,	,
cord-017640-i8h48ny6	145	44	whose	whose	WP$
cord-017640-i8h48ny6	145	45	induction	induction	NN
cord-017640-i8h48ny6	145	46	promotes	promote	VBZ
cord-017640-i8h48ny6	145	47	invasiveness	invasiveness	NN
cord-017640-i8h48ny6	145	48	in	in	IN
cord-017640-i8h48ny6	145	49	tumor	tumor	NN
cord-017640-i8h48ny6	145	50	cells	cell	NNS
cord-017640-i8h48ny6	145	51	[	[	-LRB-
cord-017640-i8h48ny6	145	52	105	105	CD
cord-017640-i8h48ny6	145	53	,	,	,
cord-017640-i8h48ny6	145	54	108	108	CD
cord-017640-i8h48ny6	145	55	]	]	-RRB-
cord-017640-i8h48ny6	145	56	.	.	.
cord-017640-i8h48ny6	146	1	In	in	IN
cord-017640-i8h48ny6	146	2	addition	addition	NN
cord-017640-i8h48ny6	146	3	,	,	,
cord-017640-i8h48ny6	146	4	mutations	mutation	NNS
cord-017640-i8h48ny6	146	5	found	find	VBN
cord-017640-i8h48ny6	146	6	in	in	IN
cord-017640-i8h48ny6	146	7	the	the	DT
cord-017640-i8h48ny6	146	8	intracellular	intracellular	JJ
cord-017640-i8h48ny6	146	9	CD95-DD	CD95-DD	NNP
cord-017640-i8h48ny6	146	10	exhibit	exhibit	NN
cord-017640-i8h48ny6	146	11	a	a	DT
cord-017640-i8h48ny6	146	12	higher	high	JJR
cord-017640-i8h48ny6	146	13	penetrance	penetrance	NN
cord-017640-i8h48ny6	146	14	of	of	IN
cord-017640-i8h48ny6	146	15	ALPS	ALPS	NNP
cord-017640-i8h48ny6	146	16	phenotype	phenotype	NN
cord-017640-i8h48ny6	146	17	features	feature	VBZ
cord-017640-i8h48ny6	146	18	in	in	IN
cord-017640-i8h48ny6	146	19	mutation	mutation	NN
cord-017640-i8h48ny6	146	20	-	-	HYPH
cord-017640-i8h48ny6	146	21	bearing	bear	VBG
cord-017640-i8h48ny6	146	22	relatives	relative	NNS
cord-017640-i8h48ny6	146	23	compared	compare	VBN
cord-017640-i8h48ny6	146	24	to	to	IN
cord-017640-i8h48ny6	146	25	extracellular	extracellular	JJ
cord-017640-i8h48ny6	146	26	mutations	mutation	NNS
cord-017640-i8h48ny6	146	27	.	.	.
cord-017640-i8h48ny6	147	1	These	these	DT
cord-017640-i8h48ny6	147	2	results	result	NNS
cord-017640-i8h48ny6	147	3	suggest	suggest	VBP
cord-017640-i8h48ny6	147	4	that	that	IN
cord-017640-i8h48ny6	147	5	unlike	unlike	IN
cord-017640-i8h48ny6	147	6	DD	DD	NNP
cord-017640-i8h48ny6	147	7	mutations	mutation	NNS
cord-017640-i8h48ny6	147	8	,	,	,
cord-017640-i8h48ny6	147	9	CD95	CD95	NNP
cord-017640-i8h48ny6	147	10	mutations	mutation	NNS
cord-017640-i8h48ny6	147	11	localized	localize	VBN
cord-017640-i8h48ny6	147	12	outside	outside	IN
cord-017640-i8h48ny6	147	13	the	the	DT
cord-017640-i8h48ny6	147	14	DD	DD	NNP
cord-017640-i8h48ny6	147	15	somehow	somehow	RB
cord-017640-i8h48ny6	147	16	prevent	prevent	VBP
cord-017640-i8h48ny6	147	17	the	the	DT
cord-017640-i8h48ny6	147	18	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	147	19	signal	signal	NN
cord-017640-i8h48ny6	147	20	but	but	CC
cord-017640-i8h48ny6	147	21	may	may	MD
cord-017640-i8h48ny6	147	22	fail	fail	VB
cord-017640-i8h48ny6	147	23	to	to	TO
cord-017640-i8h48ny6	147	24	promote	promote	VB
cord-017640-i8h48ny6	147	25	non	non	JJ
cord-017640-i8h48ny6	147	26	-	-	JJ
cord-017640-i8h48ny6	147	27	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	147	28	pathways	pathway	NNS
cord-017640-i8h48ny6	147	29	,	,	,
cord-017640-i8h48ny6	147	30	which	which	WDT
cord-017640-i8h48ny6	147	31	may	may	MD
cord-017640-i8h48ny6	147	32	contribute	contribute	VB
cord-017640-i8h48ny6	147	33	to	to	IN
cord-017640-i8h48ny6	147	34	disease	disease	NN
cord-017640-i8h48ny6	147	35	aggressiveness	aggressiveness	NN
cord-017640-i8h48ny6	147	36	.	.	.
cord-017640-i8h48ny6	148	1	In	in	IN
cord-017640-i8h48ny6	148	2	addition	addition	NN
cord-017640-i8h48ny6	148	3	to	to	IN
cord-017640-i8h48ny6	148	4	CD95	CD95	NNP
cord-017640-i8h48ny6	148	5	downregulation	downregulation	NN
cord-017640-i8h48ny6	148	6	or	or	CC
cord-017640-i8h48ny6	148	7	expression	expression	NN
cord-017640-i8h48ny6	148	8	of	of	IN
cord-017640-i8h48ny6	148	9	the	the	DT
cord-017640-i8h48ny6	148	10	mutated	mutate	VBN
cord-017640-i8h48ny6	148	11	allele	allele	NN
cord-017640-i8h48ny6	148	12	of	of	IN
cord-017640-i8h48ny6	148	13	the	the	DT
cord-017640-i8h48ny6	148	14	receptor	receptor	NN
cord-017640-i8h48ny6	148	15	,	,	,
cord-017640-i8h48ny6	148	16	the	the	DT
cord-017640-i8h48ny6	148	17	plasma	plasma	NN
cord-017640-i8h48ny6	148	18	membrane	membrane	NN
cord-017640-i8h48ny6	148	19	distribution	distribution	NN
cord-017640-i8h48ny6	148	20	of	of	IN
cord-017640-i8h48ny6	148	21	CD95	CD95	NNP
cord-017640-i8h48ny6	148	22	represents	represent	VBZ
cord-017640-i8h48ny6	148	23	an	an	DT
cord-017640-i8h48ny6	148	24	additional	additional	JJ
cord-017640-i8h48ny6	148	25	pathway	pathway	NN
cord-017640-i8h48ny6	148	26	for	for	IN
cord-017640-i8h48ny6	148	27	tumor	tumor	NN
cord-017640-i8h48ny6	148	28	cells	cell	NNS
cord-017640-i8h48ny6	148	29	to	to	TO
cord-017640-i8h48ny6	148	30	develop	develop	VB
cord-017640-i8h48ny6	148	31	resistance	resistance	NN
cord-017640-i8h48ny6	148	32	to	to	IN
cord-017640-i8h48ny6	148	33	CD95L	cd95l	NN
cord-017640-i8h48ny6	148	34	-	-	HYPH
cord-017640-i8h48ny6	148	35	expressing	express	VBG
cord-017640-i8h48ny6	148	36	immune	immune	JJ
cord-017640-i8h48ny6	148	37	cells	cell	NNS
cord-017640-i8h48ny6	148	38	.	.	.
cord-017640-i8h48ny6	149	1	Indeed	indeed	RB
cord-017640-i8h48ny6	149	2	,	,	,
cord-017640-i8h48ny6	149	3	the	the	DT
cord-017640-i8h48ny6	149	4	plasma	plasma	NN
cord-017640-i8h48ny6	149	5	membrane	membrane	NN
cord-017640-i8h48ny6	149	6	is	be	VBZ
cord-017640-i8h48ny6	149	7	a	a	DT
cord-017640-i8h48ny6	149	8	heterogeneous	heterogeneous	JJ
cord-017640-i8h48ny6	149	9	lipid	lipid	NN
cord-017640-i8h48ny6	149	10	bilayer	bilayer	NN
cord-017640-i8h48ny6	149	11	comprising	comprise	VBG
cord-017640-i8h48ny6	149	12	compacted	compacted	JJ
cord-017640-i8h48ny6	149	13	or	or	CC
cord-017640-i8h48ny6	149	14	liquid	liquid	NN
cord-017640-i8h48ny6	149	15	-	-	HYPH
cord-017640-i8h48ny6	149	16	ordered	order	VBN
cord-017640-i8h48ny6	149	17	domains	domain	NNS
cord-017640-i8h48ny6	149	18	,	,	,
cord-017640-i8h48ny6	149	19	called	call	VBN
cord-017640-i8h48ny6	149	20	microdomains	microdomains	NNP
cord-017640-i8h48ny6	149	21	,	,	,
cord-017640-i8h48ny6	149	22	lipid	lipid	NN
cord-017640-i8h48ny6	149	23	rafts	raft	NNS
cord-017640-i8h48ny6	149	24	,	,	,
cord-017640-i8h48ny6	149	25	or	or	CC
cord-017640-i8h48ny6	149	26	detergent	detergent	NN
cord-017640-i8h48ny6	149	27	-	-	HYPH
cord-017640-i8h48ny6	149	28	resistant	resistant	JJ
cord-017640-i8h48ny6	149	29	microdomains	microdomain	NNS
cord-017640-i8h48ny6	149	30	(	(	-LRB-
cord-017640-i8h48ny6	149	31	DRMs	DRMs	NNP
cord-017640-i8h48ny6	149	32	)	)	-RRB-
cord-017640-i8h48ny6	149	33	.	.	.
cord-017640-i8h48ny6	150	1	These	these	DT
cord-017640-i8h48ny6	150	2	domains	domain	NNS
cord-017640-i8h48ny6	150	3	are	be	VBP
cord-017640-i8h48ny6	150	4	described	describe	VBN
cord-017640-i8h48ny6	150	5	as	as	IN
cord-017640-i8h48ny6	150	6	floating	float	VBG
cord-017640-i8h48ny6	150	7	in	in	IN
cord-017640-i8h48ny6	150	8	a	a	DT
cord-017640-i8h48ny6	150	9	more	more	RBR
cord-017640-i8h48ny6	150	10	fluid	fluid	JJ
cord-017640-i8h48ny6	150	11	or	or	CC
cord-017640-i8h48ny6	150	12	liquid	liquid	JJ
cord-017640-i8h48ny6	150	13	-	-	HYPH
cord-017640-i8h48ny6	150	14	disordered	disordered	JJ
cord-017640-i8h48ny6	150	15	2D	2d	JJ
cord-017640-i8h48ny6	150	16	lipid	lipid	NN
cord-017640-i8h48ny6	150	17	bilayer	bilayer	NN
cord-017640-i8h48ny6	150	18	and	and	CC
cord-017640-i8h48ny6	150	19	are	be	VBP
cord-017640-i8h48ny6	150	20	enriched	enrich	VBN
cord-017640-i8h48ny6	150	21	in	in	IN
cord-017640-i8h48ny6	150	22	ceramides	ceramide	NNS
cord-017640-i8h48ny6	150	23	[	[	-LRB-
cord-017640-i8h48ny6	150	24	109	109	CD
cord-017640-i8h48ny6	150	25	]	]	-RRB-
cord-017640-i8h48ny6	150	26	.	.	.
cord-017640-i8h48ny6	151	1	It	-PRON-	PRP
cord-017640-i8h48ny6	151	2	has	have	VBZ
cord-017640-i8h48ny6	151	3	been	be	VBN
cord-017640-i8h48ny6	151	4	elegantly	elegantly	RB
cord-017640-i8h48ny6	151	5	shown	show	VBN
cord-017640-i8h48ny6	151	6	that	that	IN
cord-017640-i8h48ny6	151	7	while	while	IN
cord-017640-i8h48ny6	151	8	CD95	CD95	NNP
cord-017640-i8h48ny6	151	9	is	be	VBZ
cord-017640-i8h48ny6	151	10	mostly	mostly	RB
cord-017640-i8h48ny6	151	11	excluded	exclude	VBN
cord-017640-i8h48ny6	151	12	from	from	IN
cord-017640-i8h48ny6	151	13	lipid	lipid	NN
cord-017640-i8h48ny6	151	14	rafts	raft	NNS
cord-017640-i8h48ny6	151	15	in	in	IN
cord-017640-i8h48ny6	151	16	activated	activate	VBN
cord-017640-i8h48ny6	151	17	T	t	NN
cord-017640-i8h48ny6	151	18	-	-	HYPH
cord-017640-i8h48ny6	151	19	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	151	20	,	,	,
cord-017640-i8h48ny6	151	21	TCR	TCR	NNP
cord-017640-i8h48ny6	151	22	-	-	HYPH
cord-017640-i8h48ny6	151	23	dependent	dependent	JJ
cord-017640-i8h48ny6	151	24	reactivation	reactivation	NN
cord-017640-i8h48ny6	151	25	of	of	IN
cord-017640-i8h48ny6	151	26	these	these	DT
cord-017640-i8h48ny6	151	27	cells	cell	NNS
cord-017640-i8h48ny6	151	28	leads	lead	VBZ
cord-017640-i8h48ny6	151	29	to	to	IN
cord-017640-i8h48ny6	151	30	rapid	rapid	JJ
cord-017640-i8h48ny6	151	31	distribution	distribution	NN
cord-017640-i8h48ny6	151	32	of	of	IN
cord-017640-i8h48ny6	151	33	the	the	DT
cord-017640-i8h48ny6	151	34	death	death	NN
cord-017640-i8h48ny6	151	35	receptor	receptor	NN
cord-017640-i8h48ny6	151	36	into	into	IN
cord-017640-i8h48ny6	151	37	lipid	lipid	NN
cord-017640-i8h48ny6	151	38	rafts	raft	NNS
cord-017640-i8h48ny6	151	39	[	[	-LRB-
cord-017640-i8h48ny6	151	40	110	110	CD
cord-017640-i8h48ny6	151	41	]	]	-RRB-
cord-017640-i8h48ny6	151	42	.	.	.
cord-017640-i8h48ny6	152	1	This	this	DT
cord-017640-i8h48ny6	152	2	CD95	CD95	NNP
cord-017640-i8h48ny6	152	3	compartmentalization	compartmentalization	NN
cord-017640-i8h48ny6	152	4	contributes	contribute	VBZ
cord-017640-i8h48ny6	152	5	to	to	IN
cord-017640-i8h48ny6	152	6	reducing	reduce	VBG
cord-017640-i8h48ny6	152	7	the	the	DT
cord-017640-i8h48ny6	152	8	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	152	9	threshold	threshold	NN
cord-017640-i8h48ny6	152	10	leading	lead	VBG
cord-017640-i8h48ny6	152	11	to	to	IN
cord-017640-i8h48ny6	152	12	the	the	DT
cord-017640-i8h48ny6	152	13	clonotypic	clonotypic	NNP
cord-017640-i8h48ny6	152	14	elimination	elimination	NN
cord-017640-i8h48ny6	152	15	of	of	IN
cord-017640-i8h48ny6	152	16	activated	activate	VBN
cord-017640-i8h48ny6	152	17	T	t	NN
cord-017640-i8h48ny6	152	18	-	-	HYPH
cord-017640-i8h48ny6	152	19	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	152	20	through	through	IN
cord-017640-i8h48ny6	152	21	activation	activation	NN
cord-017640-i8h48ny6	152	22	of	of	IN
cord-017640-i8h48ny6	152	23	the	the	DT
cord-017640-i8h48ny6	152	24	CD95-mediated	cd95-mediated	CD
cord-017640-i8h48ny6	152	25	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	152	26	signal	signal	NN
cord-017640-i8h48ny6	152	27	[	[	-LRB-
cord-017640-i8h48ny6	152	28	110	110	CD
cord-017640-i8h48ny6	152	29	]	]	-RRB-
cord-017640-i8h48ny6	152	30	.	.	.
cord-017640-i8h48ny6	153	1	Similarly	similarly	RB
cord-017640-i8h48ny6	153	2	,	,	,
cord-017640-i8h48ny6	153	3	the	the	DT
cord-017640-i8h48ny6	153	4	reorganization	reorganization	NN
cord-017640-i8h48ny6	153	5	of	of	IN
cord-017640-i8h48ny6	153	6	CD95	CD95	NNP
cord-017640-i8h48ny6	153	7	into	into	IN
cord-017640-i8h48ny6	153	8	DRMs	drm	NNS
cord-017640-i8h48ny6	153	9	can	can	MD
cord-017640-i8h48ny6	153	10	occur	occur	VB
cord-017640-i8h48ny6	153	11	independent	independent	JJ
cord-017640-i8h48ny6	153	12	from	from	IN
cord-017640-i8h48ny6	153	13	ligand	ligand	NN
cord-017640-i8h48ny6	153	14	upon	upon	IN
cord-017640-i8h48ny6	153	15	addition	addition	NN
cord-017640-i8h48ny6	153	16	of	of	IN
cord-017640-i8h48ny6	153	17	certain	certain	JJ
cord-017640-i8h48ny6	153	18	chemotherapeutic	chemotherapeutic	JJ
cord-017640-i8h48ny6	153	19	drugs	drug	NNS
cord-017640-i8h48ny6	153	20	(	(	-LRB-
cord-017640-i8h48ny6	153	21	e.g.	e.g.	RB
cord-017640-i8h48ny6	153	22	,	,	,
cord-017640-i8h48ny6	153	23	rituximab	rituximab	JJ
cord-017640-i8h48ny6	153	24	[	[	-LRB-
cord-017640-i8h48ny6	153	25	111	111	CD
cord-017640-i8h48ny6	153	26	]	]	-RRB-
cord-017640-i8h48ny6	153	27	,	,	,
cord-017640-i8h48ny6	153	28	resveratrol	resveratrol	JJ
cord-017640-i8h48ny6	153	29	[	[	-LRB-
cord-017640-i8h48ny6	153	30	112	112	CD
cord-017640-i8h48ny6	153	31	,	,	,
cord-017640-i8h48ny6	153	32	113	113	CD
cord-017640-i8h48ny6	153	33	]	]	-RRB-
cord-017640-i8h48ny6	153	34	,	,	,
cord-017640-i8h48ny6	153	35	edelfosine	edelfosine	JJ
cord-017640-i8h48ny6	153	36	[	[	-LRB-
cord-017640-i8h48ny6	153	37	87	87	CD
cord-017640-i8h48ny6	153	38	,	,	,
cord-017640-i8h48ny6	153	39	114	114	CD
cord-017640-i8h48ny6	153	40	,	,	,
cord-017640-i8h48ny6	153	41	115	115	CD
cord-017640-i8h48ny6	153	42	]	]	-RRB-
cord-017640-i8h48ny6	153	43	,	,	,
cord-017640-i8h48ny6	153	44	aplidin	aplidin	NNP
cord-017640-i8h48ny6	153	45	[	[	-LRB-
cord-017640-i8h48ny6	153	46	116	116	CD
cord-017640-i8h48ny6	153	47	]	]	-RRB-
cord-017640-i8h48ny6	153	48	,	,	,
cord-017640-i8h48ny6	153	49	perifosine	perifosine	NN
cord-017640-i8h48ny6	153	50	[	[	-LRB-
cord-017640-i8h48ny6	153	51	115	115	CD
cord-017640-i8h48ny6	153	52	]	]	-RRB-
cord-017640-i8h48ny6	153	53	,	,	,
cord-017640-i8h48ny6	153	54	cisplatin	cisplatin	JJ
cord-017640-i8h48ny6	153	55	[	[	-LRB-
cord-017640-i8h48ny6	153	56	117	117	CD
cord-017640-i8h48ny6	153	57	]	]	-RRB-
cord-017640-i8h48ny6	153	58	)	)	-RRB-
cord-017640-i8h48ny6	153	59	.	.	.
cord-017640-i8h48ny6	154	1	The	the	DT
cord-017640-i8h48ny6	154	2	molecular	molecular	JJ
cord-017640-i8h48ny6	154	3	cascades	cascade	NNS
cord-017640-i8h48ny6	154	4	that	that	WDT
cord-017640-i8h48ny6	154	5	underlie	underlie	VBP
cord-017640-i8h48ny6	155	1	this	this	DT
cord-017640-i8h48ny6	155	2	process	process	NN
cord-017640-i8h48ny6	155	3	remain	remain	VBP
cord-017640-i8h48ny6	155	4	elusive	elusive	JJ
cord-017640-i8h48ny6	155	5	.	.	.
cord-017640-i8h48ny6	156	1	Nevertheless	nevertheless	RB
cord-017640-i8h48ny6	156	2	,	,	,
cord-017640-i8h48ny6	156	3	a	a	DT
cord-017640-i8h48ny6	156	4	growing	grow	VBG
cord-017640-i8h48ny6	156	5	body	body	NN
cord-017640-i8h48ny6	156	6	of	of	IN
cord-017640-i8h48ny6	156	7	evidence	evidence	NN
cord-017640-i8h48ny6	156	8	leads	lead	VBZ
cord-017640-i8h48ny6	156	9	us	-PRON-	PRP
cord-017640-i8h48ny6	156	10	to	to	TO
cord-017640-i8h48ny6	156	11	postulate	postulate	VB
cord-017640-i8h48ny6	156	12	that	that	IN
cord-017640-i8h48ny6	156	13	alteration	alteration	NN
cord-017640-i8h48ny6	156	14	of	of	IN
cord-017640-i8h48ny6	156	15	intracellular	intracellular	JJ
cord-017640-i8h48ny6	156	16	signaling	signal	VBG
cord-017640-i8h48ny6	156	17	pathway(s	pathway(s	NN
cord-017640-i8h48ny6	156	18	)	)	-RRB-
cord-017640-i8h48ny6	156	19	,	,	,
cord-017640-i8h48ny6	156	20	such	such	JJ
cord-017640-i8h48ny6	156	21	as	as	IN
cord-017640-i8h48ny6	156	22	the	the	DT
cord-017640-i8h48ny6	156	23	aforementioned	aforementioned	JJ
cord-017640-i8h48ny6	156	24	PI3	pi3	NN
cord-017640-i8h48ny6	156	25	K	K	NNP
cord-017640-i8h48ny6	156	26	signal	signal	NN
cord-017640-i8h48ny6	156	27	[	[	-LRB-
cord-017640-i8h48ny6	156	28	87	87	CD
cord-017640-i8h48ny6	156	29	,	,	,
cord-017640-i8h48ny6	156	30	90	90	CD
cord-017640-i8h48ny6	156	31	]	]	-RRB-
cord-017640-i8h48ny6	156	32	,	,	,
cord-017640-i8h48ny6	156	33	may	may	MD
cord-017640-i8h48ny6	156	34	change	change	VB
cord-017640-i8h48ny6	156	35	biophysical	biophysical	JJ
cord-017640-i8h48ny6	156	36	properties	property	NNS
cord-017640-i8h48ny6	156	37	of	of	IN
cord-017640-i8h48ny6	156	38	the	the	DT
cord-017640-i8h48ny6	156	39	plasma	plasma	NN
cord-017640-i8h48ny6	156	40	membrane	membrane	NN
cord-017640-i8h48ny6	156	41	,	,	,
cord-017640-i8h48ny6	156	42	such	such	JJ
cord-017640-i8h48ny6	156	43	as	as	IN
cord-017640-i8h48ny6	156	44	membrane	membrane	NN
cord-017640-i8h48ny6	156	45	fluidity	fluidity	NN
cord-017640-i8h48ny6	156	46	,	,	,
cord-017640-i8h48ny6	156	47	which	which	WDT
cord-017640-i8h48ny6	156	48	in	in	IN
cord-017640-i8h48ny6	156	49	turn	turn	NN
cord-017640-i8h48ny6	156	50	may	may	MD
cord-017640-i8h48ny6	156	51	facilitate	facilitate	VB
cord-017640-i8h48ny6	156	52	CD95	CD95	NNP
cord-017640-i8h48ny6	156	53	clustering	cluster	VBG
cord-017640-i8h48ny6	156	54	into	into	IN
cord-017640-i8h48ny6	156	55	large	large	JJ
cord-017640-i8h48ny6	156	56	lipid	lipid	NN
cord-017640-i8h48ny6	156	57	raft	raft	NN
cord-017640-i8h48ny6	156	58	-	-	HYPH
cord-017640-i8h48ny6	156	59	enriched	enrich	VBN
cord-017640-i8h48ny6	156	60	platforms	platform	NNS
cord-017640-i8h48ny6	156	61	,	,	,
cord-017640-i8h48ny6	156	62	favoring	favor	VBG
cord-017640-i8h48ny6	156	63	DISC	disc	NN
cord-017640-i8h48ny6	156	64	formation	formation	NN
cord-017640-i8h48ny6	156	65	and	and	CC
cord-017640-i8h48ny6	156	66	induction	induction	NN
cord-017640-i8h48ny6	156	67	of	of	IN
cord-017640-i8h48ny6	156	68	the	the	DT
cord-017640-i8h48ny6	156	69	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	156	70	program	program	NN
cord-017640-i8h48ny6	156	71	[	[	-LRB-
cord-017640-i8h48ny6	156	72	118	118	CD
cord-017640-i8h48ny6	156	73	]	]	-RRB-
cord-017640-i8h48ny6	156	74	.	.	.
cord-017640-i8h48ny6	157	1	Accumulation	accumulation	NN
cord-017640-i8h48ny6	157	2	of	of	IN
cord-017640-i8h48ny6	157	3	CD95	CD95	NNP
cord-017640-i8h48ny6	157	4	mutations	mutation	NNS
cord-017640-i8h48ny6	157	5	is	be	VBZ
cord-017640-i8h48ny6	157	6	not	not	RB
cord-017640-i8h48ny6	157	7	the	the	DT
cord-017640-i8h48ny6	157	8	only	only	JJ
cord-017640-i8h48ny6	157	9	mechanism	mechanism	NN
cord-017640-i8h48ny6	157	10	by	by	IN
cord-017640-i8h48ny6	157	11	which	which	WDT
cord-017640-i8h48ny6	157	12	malignant	malignant	JJ
cord-017640-i8h48ny6	157	13	cells	cell	NNS
cord-017640-i8h48ny6	157	14	inhibit	inhibit	VBP
cord-017640-i8h48ny6	157	15	the	the	DT
cord-017640-i8h48ny6	157	16	extrinsic	extrinsic	JJ
cord-017640-i8h48ny6	157	17	signaling	signal	VBG
cord-017640-i8h48ny6	157	18	pathway	pathway	NN
cord-017640-i8h48ny6	157	19	.	.	.
cord-017640-i8h48ny6	158	1	Posttranslational	posttranslational	JJ
cord-017640-i8h48ny6	158	2	modifications	modification	NNS
cord-017640-i8h48ny6	158	3	in	in	IN
cord-017640-i8h48ny6	158	4	the	the	DT
cord-017640-i8h48ny6	158	5	intracellular	intracellular	JJ
cord-017640-i8h48ny6	158	6	tail	tail	NN
cord-017640-i8h48ny6	158	7	of	of	IN
cord-017640-i8h48ny6	158	8	CD95	CD95	NNP
cord-017640-i8h48ny6	158	9	,	,	,
cord-017640-i8h48ny6	158	10	such	such	JJ
cord-017640-i8h48ny6	158	11	as	as	IN
cord-017640-i8h48ny6	158	12	reversible	reversible	JJ
cord-017640-i8h48ny6	158	13	oxidation	oxidation	NN
cord-017640-i8h48ny6	158	14	or	or	CC
cord-017640-i8h48ny6	158	15	covalent	covalent	JJ
cord-017640-i8h48ny6	158	16	attachment	attachment	NN
cord-017640-i8h48ny6	158	17	of	of	IN
cord-017640-i8h48ny6	158	18	a	a	DT
cord-017640-i8h48ny6	158	19	palmitic	palmitic	JJ
cord-017640-i8h48ny6	158	20	acid	acid	NN
cord-017640-i8h48ny6	158	21	,	,	,
cord-017640-i8h48ny6	158	22	were	be	VBD
cord-017640-i8h48ny6	158	23	reported	report	VBN
cord-017640-i8h48ny6	158	24	to	to	TO
cord-017640-i8h48ny6	158	25	alter	alter	VB
cord-017640-i8h48ny6	158	26	the	the	DT
cord-017640-i8h48ny6	158	27	plasma	plasma	NN
cord-017640-i8h48ny6	158	28	membrane	membrane	NN
cord-017640-i8h48ny6	158	29	distribution	distribution	NN
cord-017640-i8h48ny6	158	30	of	of	IN
cord-017640-i8h48ny6	158	31	CD95	CD95	NNP
cord-017640-i8h48ny6	158	32	and	and	CC
cord-017640-i8h48ny6	158	33	thereby	thereby	RB
cord-017640-i8h48ny6	158	34	its	-PRON-	PRP$
cord-017640-i8h48ny6	158	35	subsequent	subsequent	JJ
cord-017640-i8h48ny6	158	36	signaling	signal	VBG
cord-017640-i8h48ny6	158	37	pathway	pathway	NN
cord-017640-i8h48ny6	158	38	.	.	.
cord-017640-i8h48ny6	159	1	For	for	IN
cord-017640-i8h48ny6	159	2	instance	instance	NN
cord-017640-i8h48ny6	159	3	,	,	,
cord-017640-i8h48ny6	159	4	S	s	NN
cord-017640-i8h48ny6	159	5	-	-	HYPH
cord-017640-i8h48ny6	159	6	glutathionylation	glutathionylation	NN
cord-017640-i8h48ny6	159	7	of	of	IN
cord-017640-i8h48ny6	159	8	mouse	mouse	NN
cord-017640-i8h48ny6	159	9	CD95	CD95	NNP
cord-017640-i8h48ny6	159	10	at	at	IN
cord-017640-i8h48ny6	159	11	cysteine	cysteine	NN
cord-017640-i8h48ny6	159	12	294	294	CD
cord-017640-i8h48ny6	159	13	promotes	promote	VBZ
cord-017640-i8h48ny6	159	14	clustering	clustering	NN
cord-017640-i8h48ny6	159	15	of	of	IN
cord-017640-i8h48ny6	159	16	CD95	CD95	NNP
cord-017640-i8h48ny6	159	17	and	and	CC
cord-017640-i8h48ny6	159	18	its	-PRON-	PRP$
cord-017640-i8h48ny6	159	19	distribution	distribution	NN
cord-017640-i8h48ny6	159	20	into	into	IN
cord-017640-i8h48ny6	159	21	lipid	lipid	NN
cord-017640-i8h48ny6	159	22	rafts	raft	NNS
cord-017640-i8h48ny6	159	23	[	[	-LRB-
cord-017640-i8h48ny6	159	24	119	119	CD
cord-017640-i8h48ny6	159	25	]	]	-RRB-
cord-017640-i8h48ny6	159	26	.	.	.
cord-017640-i8h48ny6	160	1	This	this	DT
cord-017640-i8h48ny6	160	2	amino	amino	NN
cord-017640-i8h48ny6	160	3	acid	acid	NN
cord-017640-i8h48ny6	160	4	is	be	VBZ
cord-017640-i8h48ny6	160	5	conserved	conserve	VBN
cord-017640-i8h48ny6	160	6	in	in	IN
cord-017640-i8h48ny6	160	7	the	the	DT
cord-017640-i8h48ny6	160	8	human	human	JJ
cord-017640-i8h48ny6	160	9	CD95	CD95	NNP
cord-017640-i8h48ny6	160	10	sequence	sequence	NN
cord-017640-i8h48ny6	160	11	and	and	CC
cord-017640-i8h48ny6	160	12	corresponds	correspond	VBZ
cord-017640-i8h48ny6	160	13	to	to	IN
cord-017640-i8h48ny6	160	14	cysteine	cysteine	NN
cord-017640-i8h48ny6	160	15	304	304	CD
cord-017640-i8h48ny6	160	16	(	(	-LRB-
cord-017640-i8h48ny6	160	17	or	or	CC
cord-017640-i8h48ny6	160	18	C288	C288	NNPS
cord-017640-i8h48ny6	160	19	when	when	WRB
cord-017640-i8h48ny6	160	20	subtraction	subtraction	NN
cord-017640-i8h48ny6	160	21	of	of	IN
cord-017640-i8h48ny6	160	22	the	the	DT
cord-017640-i8h48ny6	160	23	16-amino	16-amino	CD
cord-017640-i8h48ny6	160	24	acid	acid	NN
cord-017640-i8h48ny6	160	25	signal	signal	NN
cord-017640-i8h48ny6	160	26	peptide	peptide	NN
cord-017640-i8h48ny6	160	27	is	be	VBZ
cord-017640-i8h48ny6	160	28	taken	take	VBN
cord-017640-i8h48ny6	160	29	into	into	IN
cord-017640-i8h48ny6	160	30	consideration	consideration	NN
cord-017640-i8h48ny6	160	31	[	[	-LRB-
cord-017640-i8h48ny6	160	32	12	12	CD
cord-017640-i8h48ny6	160	33	,	,	,
cord-017640-i8h48ny6	160	34	120	120	CD
cord-017640-i8h48ny6	160	35	]	]	-RRB-
cord-017640-i8h48ny6	160	36	)	)	-RRB-
cord-017640-i8h48ny6	160	37	.	.	.
cord-017640-i8h48ny6	161	1	Interestingly	interestingly	RB
cord-017640-i8h48ny6	161	2	,	,	,
cord-017640-i8h48ny6	161	3	Janssen	Janssen	NNP
cord-017640-i8h48ny6	161	4	-	-	HYPH
cord-017640-i8h48ny6	161	5	Heininger	Heininger	NNP
cord-017640-i8h48ny6	161	6	and	and	CC
cord-017640-i8h48ny6	161	7	colleagues	colleague	NNS
cord-017640-i8h48ny6	161	8	emphasize	emphasize	VBP
cord-017640-i8h48ny6	161	9	that	that	IN
cord-017640-i8h48ny6	161	10	death	death	NN
cord-017640-i8h48ny6	161	11	receptor	receptor	NN
cord-017640-i8h48ny6	161	12	glutathionylation	glutathionylation	NN
cord-017640-i8h48ny6	161	13	occurs	occur	VBZ
cord-017640-i8h48ny6	161	14	downstream	downstream	NN
cord-017640-i8h48ny6	161	15	of	of	IN
cord-017640-i8h48ny6	161	16	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	161	17	and	and	CC
cord-017640-i8h48ny6	161	18	caspase-3	caspase-3	NNP
cord-017640-i8h48ny6	161	19	activation	activation	NN
cord-017640-i8h48ny6	162	1	whose	whose	WP$
cord-017640-i8h48ny6	162	2	catalytic	catalytic	JJ
cord-017640-i8h48ny6	162	3	activity	activity	NN
cord-017640-i8h48ny6	162	4	damages	damage	VBZ
cord-017640-i8h48ny6	162	5	the	the	DT
cord-017640-i8h48ny6	162	6	thioltransferase	thioltransferase	NNP
cord-017640-i8h48ny6	162	7	glutaredoxin	glutaredoxin	NNP
cord-017640-i8h48ny6	162	8	1	1	CD
cord-017640-i8h48ny6	162	9	(	(	-LRB-
cord-017640-i8h48ny6	162	10	Grx1	Grx1	NNP
cord-017640-i8h48ny6	162	11	)	)	-RRB-
cord-017640-i8h48ny6	162	12	,	,	,
cord-017640-i8h48ny6	162	13	an	an	DT
cord-017640-i8h48ny6	162	14	enzyme	enzyme	NN
cord-017640-i8h48ny6	162	15	implicated	implicate	VBN
cord-017640-i8h48ny6	162	16	in	in	IN
cord-017640-i8h48ny6	162	17	the	the	DT
cord-017640-i8h48ny6	162	18	denitrosylation	denitrosylation	NN
cord-017640-i8h48ny6	162	19	of	of	IN
cord-017640-i8h48ny6	162	20	proteins	protein	NNS
cord-017640-i8h48ny6	162	21	[	[	-LRB-
cord-017640-i8h48ny6	162	22	119	119	CD
cord-017640-i8h48ny6	162	23	]	]	-RRB-
cord-017640-i8h48ny6	162	24	.	.	.
cord-017640-i8h48ny6	163	1	The	the	DT
cord-017640-i8h48ny6	163	2	consequence	consequence	NN
cord-017640-i8h48ny6	163	3	of	of	IN
cord-017640-i8h48ny6	163	4	Grx1	Grx1	NNP
cord-017640-i8h48ny6	163	5	inactivation	inactivation	NN
cord-017640-i8h48ny6	163	6	is	be	VBZ
cord-017640-i8h48ny6	163	7	the	the	DT
cord-017640-i8h48ny6	163	8	accumulation	accumulation	NN
cord-017640-i8h48ny6	163	9	of	of	IN
cord-017640-i8h48ny6	163	10	glutathionylated	glutathionylate	VBN
cord-017640-i8h48ny6	163	11	CD95	CD95	NNP
cord-017640-i8h48ny6	163	12	,	,	,
cord-017640-i8h48ny6	163	13	which	which	WDT
cord-017640-i8h48ny6	163	14	clusters	cluster	VBZ
cord-017640-i8h48ny6	163	15	into	into	IN
cord-017640-i8h48ny6	163	16	lipid	lipid	NN
cord-017640-i8h48ny6	163	17	rafts	raft	NNS
cord-017640-i8h48ny6	163	18	,	,	,
cord-017640-i8h48ny6	163	19	sensitizing	sensitize	VBG
cord-017640-i8h48ny6	163	20	cells	cell	NNS
cord-017640-i8h48ny6	163	21	to	to	IN
cord-017640-i8h48ny6	163	22	the	the	DT
cord-017640-i8h48ny6	163	23	CD95-mediated	cd95-mediated	CD
cord-017640-i8h48ny6	163	24	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	163	25	signal	signal	NN
cord-017640-i8h48ny6	163	26	.	.	.
cord-017640-i8h48ny6	164	1	Based	base	VBN
cord-017640-i8h48ny6	164	2	on	on	IN
cord-017640-i8h48ny6	164	3	these	these	DT
cord-017640-i8h48ny6	164	4	findings	finding	NNS
cord-017640-i8h48ny6	164	5	,	,	,
cord-017640-i8h48ny6	164	6	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	164	7	activation	activation	NN
cord-017640-i8h48ny6	164	8	occurs	occur	VBZ
cord-017640-i8h48ny6	164	9	prior	prior	RB
cord-017640-i8h48ny6	164	10	to	to	IN
cord-017640-i8h48ny6	164	11	aggregation	aggregation	NN
cord-017640-i8h48ny6	164	12	of	of	IN
cord-017640-i8h48ny6	164	13	CD95	CD95	NNP
cord-017640-i8h48ny6	164	14	and	and	CC
cord-017640-i8h48ny6	164	15	redistribution	redistribution	NN
cord-017640-i8h48ny6	164	16	into	into	IN
cord-017640-i8h48ny6	164	17	lipid	lipid	NN
cord-017640-i8h48ny6	164	18	rafts	raft	NNS
cord-017640-i8h48ny6	164	19	,	,	,
cord-017640-i8h48ny6	164	20	both	both	DT
cord-017640-i8h48ny6	164	21	of	of	IN
cord-017640-i8h48ny6	164	22	which	which	WDT
cord-017640-i8h48ny6	164	23	are	be	VBP
cord-017640-i8h48ny6	164	24	requisite	requisite	JJ
cord-017640-i8h48ny6	164	25	to	to	TO
cord-017640-i8h48ny6	164	26	form	form	VB
cord-017640-i8h48ny6	164	27	the	the	DT
cord-017640-i8h48ny6	164	28	DISC	disc	NN
cord-017640-i8h48ny6	164	29	and	and	CC
cord-017640-i8h48ny6	164	30	subsequently	subsequently	RB
cord-017640-i8h48ny6	164	31	activate	activate	VB
cord-017640-i8h48ny6	164	32	larger	large	JJR
cord-017640-i8h48ny6	164	33	amounts	amount	NNS
cord-017640-i8h48ny6	164	34	of	of	IN
cord-017640-i8h48ny6	164	35	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	164	36	.	.	.
cord-017640-i8h48ny6	165	1	In	in	IN
cord-017640-i8h48ny6	165	2	agreement	agreement	NN
cord-017640-i8h48ny6	165	3	with	with	IN
cord-017640-i8h48ny6	165	4	these	these	DT
cord-017640-i8h48ny6	165	5	observations	observation	NNS
cord-017640-i8h48ny6	165	6	,	,	,
cord-017640-i8h48ny6	165	7	activation	activation	NN
cord-017640-i8h48ny6	165	8	of	of	IN
cord-017640-i8h48ny6	165	9	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	165	10	was	be	VBD
cord-017640-i8h48ny6	165	11	reported	report	VBN
cord-017640-i8h48ny6	165	12	to	to	TO
cord-017640-i8h48ny6	165	13	occur	occur	VB
cord-017640-i8h48ny6	165	14	in	in	IN
cord-017640-i8h48ny6	165	15	a	a	DT
cord-017640-i8h48ny6	165	16	two	two	CD
cord-017640-i8h48ny6	165	17	-	-	HYPH
cord-017640-i8h48ny6	165	18	step	step	NN
cord-017640-i8h48ny6	165	19	process	process	NN
cord-017640-i8h48ny6	165	20	.	.	.
cord-017640-i8h48ny6	166	1	That	that	RB
cord-017640-i8h48ny6	166	2	is	is	RB
cord-017640-i8h48ny6	166	3	,	,	,
cord-017640-i8h48ny6	166	4	an	an	DT
cord-017640-i8h48ny6	166	5	immediate	immediate	JJ
cord-017640-i8h48ny6	166	6	and	and	CC
cord-017640-i8h48ny6	166	7	small	small	JJ
cord-017640-i8h48ny6	166	8	amount	amount	NN
cord-017640-i8h48ny6	166	9	of	of	IN
cord-017640-i8h48ny6	166	10	activated	activate	VBN
cord-017640-i8h48ny6	166	11	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	166	12	(	(	-LRB-
cord-017640-i8h48ny6	166	13	<	<	NNP
cord-017640-i8h48ny6	166	14	1	1	CD
cord-017640-i8h48ny6	166	15	%	%	NN
cord-017640-i8h48ny6	166	16	)	)	-RRB-
cord-017640-i8h48ny6	166	17	is	be	VBZ
cord-017640-i8h48ny6	166	18	generated	generate	VBN
cord-017640-i8h48ny6	166	19	when	when	WRB
cord-017640-i8h48ny6	166	20	CD95L	cd95l	NN
cord-017640-i8h48ny6	166	21	interacts	interact	VBZ
cord-017640-i8h48ny6	166	22	with	with	IN
cord-017640-i8h48ny6	166	23	CD95	CD95	NNP
cord-017640-i8h48ny6	166	24	that	that	WDT
cord-017640-i8h48ny6	166	25	orchestrates	orchestrate	VBZ
cord-017640-i8h48ny6	166	26	acid	acid	NN
cord-017640-i8h48ny6	166	27	sphingomyelinase	sphingomyelinase	NN
cord-017640-i8h48ny6	166	28	(	(	-LRB-
cord-017640-i8h48ny6	166	29	ASM	ASM	NNP
cord-017640-i8h48ny6	166	30	)	)	-RRB-
cord-017640-i8h48ny6	166	31	activation	activation	NN
cord-017640-i8h48ny6	166	32	,	,	,
cord-017640-i8h48ny6	166	33	ceramide	ceramide	NN
cord-017640-i8h48ny6	166	34	production	production	NN
cord-017640-i8h48ny6	166	35	,	,	,
cord-017640-i8h48ny6	166	36	and	and	CC
cord-017640-i8h48ny6	166	37	CD95	CD95	NNP
cord-017640-i8h48ny6	166	38	clustering	clustering	NN
cord-017640-i8h48ny6	166	39	,	,	,
cord-017640-i8h48ny6	166	40	which	which	WDT
cord-017640-i8h48ny6	166	41	in	in	IN
cord-017640-i8h48ny6	166	42	turn	turn	NN
cord-017640-i8h48ny6	166	43	promote	promote	VBP
cord-017640-i8h48ny6	166	44	DISC	disc	NN
cord-017640-i8h48ny6	166	45	formation	formation	NN
cord-017640-i8h48ny6	166	46	and	and	CC
cord-017640-i8h48ny6	166	47	the	the	DT
cord-017640-i8h48ny6	166	48	outburst	outburst	NN
cord-017640-i8h48ny6	166	49	of	of	IN
cord-017640-i8h48ny6	166	50	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	166	51	processing	processing	NN
cord-017640-i8h48ny6	166	52	essential	essential	JJ
cord-017640-i8h48ny6	166	53	to	to	TO
cord-017640-i8h48ny6	166	54	mount	mount	VB
cord-017640-i8h48ny6	166	55	the	the	DT
cord-017640-i8h48ny6	166	56	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	166	57	signal	signal	NN
cord-017640-i8h48ny6	166	58	[	[	-LRB-
cord-017640-i8h48ny6	166	59	121	121	CD
cord-017640-i8h48ny6	166	60	]	]	-RRB-
cord-017640-i8h48ny6	166	61	.	.	.
cord-017640-i8h48ny6	167	1	S	S	NNP
cord-017640-i8h48ny6	167	2	-	-	HYPH
cord-017640-i8h48ny6	167	3	Glutathionylation	Glutathionylation	NNP
cord-017640-i8h48ny6	167	4	consists	consist	VBZ
cord-017640-i8h48ny6	167	5	in	in	IN
cord-017640-i8h48ny6	167	6	a	a	DT
cord-017640-i8h48ny6	167	7	bond	bond	NN
cord-017640-i8h48ny6	167	8	between	between	IN
cord-017640-i8h48ny6	167	9	a	a	DT
cord-017640-i8h48ny6	167	10	reactive	reactive	JJ
cord-017640-i8h48ny6	167	11	Cys	Cys	NNP
cord-017640-i8h48ny6	167	12	-	-	HYPH
cord-017640-i8h48ny6	167	13	thiol	thiol	NN
cord-017640-i8h48ny6	167	14	and	and	CC
cord-017640-i8h48ny6	167	15	reduced	reduce	VBN
cord-017640-i8h48ny6	167	16	glutathione	glutathione	NN
cord-017640-i8h48ny6	167	17	(	(	-LRB-
cord-017640-i8h48ny6	167	18	GSH	GSH	NNP
cord-017640-i8h48ny6	167	19	)	)	-RRB-
cord-017640-i8h48ny6	167	20	,	,	,
cord-017640-i8h48ny6	167	21	a	a	DT
cord-017640-i8h48ny6	167	22	tripeptide	tripeptide	NN
cord-017640-i8h48ny6	167	23	consisting	consist	VBG
cord-017640-i8h48ny6	167	24	of	of	IN
cord-017640-i8h48ny6	167	25	glycine	glycine	NN
cord-017640-i8h48ny6	167	26	,	,	,
cord-017640-i8h48ny6	167	27	cysteine	cysteine	NN
cord-017640-i8h48ny6	167	28	,	,	,
cord-017640-i8h48ny6	167	29	and	and	CC
cord-017640-i8h48ny6	167	30	glutamate	glutamate	NN
cord-017640-i8h48ny6	167	31	;	;	:
cord-017640-i8h48ny6	167	32	its	-PRON-	PRP$
cord-017640-i8h48ny6	167	33	attachment	attachment	NN
cord-017640-i8h48ny6	167	34	to	to	IN
cord-017640-i8h48ny6	167	35	the	the	DT
cord-017640-i8h48ny6	167	36	protein	protein	NN
cord-017640-i8h48ny6	167	37	will	will	MD
cord-017640-i8h48ny6	167	38	alter	alter	VB
cord-017640-i8h48ny6	167	39	its	-PRON-	PRP$
cord-017640-i8h48ny6	167	40	structure	structure	NN
cord-017640-i8h48ny6	167	41	and	and	CC
cord-017640-i8h48ny6	167	42	function	function	NN
cord-017640-i8h48ny6	167	43	in	in	IN
cord-017640-i8h48ny6	167	44	a	a	DT
cord-017640-i8h48ny6	167	45	manner	manner	NN
cord-017640-i8h48ny6	167	46	similar	similar	JJ
cord-017640-i8h48ny6	167	47	to	to	IN
cord-017640-i8h48ny6	167	48	the	the	DT
cord-017640-i8h48ny6	167	49	addition	addition	NN
cord-017640-i8h48ny6	167	50	of	of	IN
cord-017640-i8h48ny6	167	51	a	a	DT
cord-017640-i8h48ny6	167	52	phosphate	phosphate	NN
cord-017640-i8h48ny6	167	53	[	[	-LRB-
cord-017640-i8h48ny6	167	54	122	122	CD
cord-017640-i8h48ny6	167	55	]	]	-RRB-
cord-017640-i8h48ny6	167	56	.	.	.
cord-017640-i8h48ny6	168	1	S	S	NNP
cord-017640-i8h48ny6	168	2	-	-	HYPH
cord-017640-i8h48ny6	168	3	Glutathionylation	Glutathionylation	NNP
cord-017640-i8h48ny6	168	4	is	be	VBZ
cord-017640-i8h48ny6	168	5	not	not	RB
cord-017640-i8h48ny6	168	6	the	the	DT
cord-017640-i8h48ny6	168	7	only	only	JJ
cord-017640-i8h48ny6	168	8	posttranslational	posttranslational	JJ
cord-017640-i8h48ny6	168	9	modification	modification	NN
cord-017640-i8h48ny6	168	10	of	of	IN
cord-017640-i8h48ny6	168	11	CD95	CD95	NNP
cord-017640-i8h48ny6	168	12	on	on	IN
cord-017640-i8h48ny6	168	13	a	a	DT
cord-017640-i8h48ny6	168	14	cysteine	cysteine	NN
cord-017640-i8h48ny6	168	15	.	.	.
cord-017640-i8h48ny6	169	1	S	S	NNP
cord-017640-i8h48ny6	169	2	-	-	HYPH
cord-017640-i8h48ny6	169	3	Nitrosylation	Nitrosylation	NNP
cord-017640-i8h48ny6	169	4	of	of	IN
cord-017640-i8h48ny6	169	5	cysteine	cysteine	NN
cord-017640-i8h48ny6	169	6	199	199	CD
cord-017640-i8h48ny6	170	1	(	(	-LRB-
cord-017640-i8h48ny6	170	2	corresponding	correspond	VBG
cord-017640-i8h48ny6	170	3	to	to	IN
cord-017640-i8h48ny6	170	4	C183	c183	PRP
cord-017640-i8h48ny6	170	5	after	after	IN
cord-017640-i8h48ny6	170	6	subtraction	subtraction	NN
cord-017640-i8h48ny6	170	7	of	of	IN
cord-017640-i8h48ny6	170	8	signal	signal	NN
cord-017640-i8h48ny6	170	9	peptide	peptide	NN
cord-017640-i8h48ny6	170	10	sequence	sequence	NN
cord-017640-i8h48ny6	170	11	)	)	-RRB-
cord-017640-i8h48ny6	170	12	and	and	CC
cord-017640-i8h48ny6	170	13	304	304	CD
cord-017640-i8h48ny6	170	14	(	(	-LRB-
cord-017640-i8h48ny6	170	15	C288	C288	NNPS
cord-017640-i8h48ny6	170	16	)	)	-RRB-
cord-017640-i8h48ny6	170	17	in	in	IN
cord-017640-i8h48ny6	170	18	colon	colon	NN
cord-017640-i8h48ny6	170	19	and	and	CC
cord-017640-i8h48ny6	170	20	breast	breast	NN
cord-017640-i8h48ny6	170	21	tumor	tumor	NN
cord-017640-i8h48ny6	170	22	cells	cell	NNS
cord-017640-i8h48ny6	170	23	also	also	RB
cord-017640-i8h48ny6	170	24	promotes	promote	VBZ
cord-017640-i8h48ny6	170	25	the	the	DT
cord-017640-i8h48ny6	170	26	redistribution	redistribution	NN
cord-017640-i8h48ny6	170	27	of	of	IN
cord-017640-i8h48ny6	170	28	CD95	CD95	NNP
cord-017640-i8h48ny6	170	29	into	into	IN
cord-017640-i8h48ny6	170	30	DRMs	drm	NNS
cord-017640-i8h48ny6	170	31	,	,	,
cord-017640-i8h48ny6	170	32	the	the	DT
cord-017640-i8h48ny6	170	33	formation	formation	NN
cord-017640-i8h48ny6	170	34	of	of	IN
cord-017640-i8h48ny6	170	35	the	the	DT
cord-017640-i8h48ny6	170	36	DISC	disc	NN
cord-017640-i8h48ny6	170	37	,	,	,
cord-017640-i8h48ny6	170	38	and	and	CC
cord-017640-i8h48ny6	170	39	the	the	DT
cord-017640-i8h48ny6	170	40	transmission	transmission	NN
cord-017640-i8h48ny6	170	41	of	of	IN
cord-017640-i8h48ny6	170	42	the	the	DT
cord-017640-i8h48ny6	170	43	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	170	44	signal	signal	NN
cord-017640-i8h48ny6	170	45	[	[	-LRB-
cord-017640-i8h48ny6	170	46	123	123	CD
cord-017640-i8h48ny6	170	47	]	]	-RRB-
cord-017640-i8h48ny6	170	48	.	.	.
cord-017640-i8h48ny6	171	1	Two	two	CD
cord-017640-i8h48ny6	171	2	reports	report	NNS
cord-017640-i8h48ny6	171	3	have	have	VBP
cord-017640-i8h48ny6	171	4	brought	bring	VBN
cord-017640-i8h48ny6	171	5	into	into	IN
cord-017640-i8h48ny6	171	6	light	light	NN
cord-017640-i8h48ny6	171	7	that	that	DT
cord-017640-i8h48ny6	171	8	covalent	covalent	JJ
cord-017640-i8h48ny6	171	9	coupling	coupling	NN
cord-017640-i8h48ny6	171	10	of	of	IN
cord-017640-i8h48ny6	171	11	a	a	DT
cord-017640-i8h48ny6	171	12	16-carbon	16-carbon	CD
cord-017640-i8h48ny6	171	13	fatty	fatty	JJ
cord-017640-i8h48ny6	171	14	acid	acid	NN
cord-017640-i8h48ny6	171	15	(	(	-LRB-
cord-017640-i8h48ny6	171	16	palmitic	palmitic	JJ
cord-017640-i8h48ny6	171	17	acid	acid	NN
cord-017640-i8h48ny6	171	18	)	)	-RRB-
cord-017640-i8h48ny6	171	19	to	to	IN
cord-017640-i8h48ny6	171	20	cysteine	cysteine	NN
cord-017640-i8h48ny6	171	21	199	199	CD
cord-017640-i8h48ny6	172	1	(	(	-LRB-
cord-017640-i8h48ny6	172	2	C183	C183	NFP
cord-017640-i8h48ny6	172	3	)	)	-RRB-
cord-017640-i8h48ny6	172	4	elicits	elicit	VBZ
cord-017640-i8h48ny6	172	5	the	the	DT
cord-017640-i8h48ny6	172	6	redistribution	redistribution	NN
cord-017640-i8h48ny6	172	7	of	of	IN
cord-017640-i8h48ny6	172	8	CD95	CD95	NNP
cord-017640-i8h48ny6	172	9	into	into	IN
cord-017640-i8h48ny6	172	10	DRMs	drm	NNS
cord-017640-i8h48ny6	172	11	,	,	,
cord-017640-i8h48ny6	172	12	the	the	DT
cord-017640-i8h48ny6	172	13	formation	formation	NN
cord-017640-i8h48ny6	172	14	of	of	IN
cord-017640-i8h48ny6	172	15	SDS	sds	NN
cord-017640-i8h48ny6	172	16	-	-	HYPH
cord-017640-i8h48ny6	172	17	stable	stable	JJ
cord-017640-i8h48ny6	172	18	CD95	CD95	NNP
cord-017640-i8h48ny6	172	19	microaggregates	microaggregate	VBZ
cord-017640-i8h48ny6	172	20	resistant	resistant	JJ
cord-017640-i8h48ny6	172	21	to	to	IN
cord-017640-i8h48ny6	172	22	denaturing	denature	VBG
cord-017640-i8h48ny6	172	23	and	and	CC
cord-017640-i8h48ny6	172	24	reducing	reduce	VBG
cord-017640-i8h48ny6	172	25	treatments	treatment	NNS
cord-017640-i8h48ny6	172	26	,	,	,
cord-017640-i8h48ny6	172	27	and	and	CC
cord-017640-i8h48ny6	172	28	the	the	DT
cord-017640-i8h48ny6	172	29	internalization	internalization	NN
cord-017640-i8h48ny6	172	30	of	of	IN
cord-017640-i8h48ny6	172	31	the	the	DT
cord-017640-i8h48ny6	172	32	receptor	receptor	NN
cord-017640-i8h48ny6	172	33	[	[	-LRB-
cord-017640-i8h48ny6	172	34	124	124	CD
cord-017640-i8h48ny6	172	35	,	,	,
cord-017640-i8h48ny6	172	36	125	125	CD
cord-017640-i8h48ny6	172	37	]	]	-RRB-
cord-017640-i8h48ny6	172	38	.	.	.
cord-017640-i8h48ny6	173	1	Although	although	IN
cord-017640-i8h48ny6	173	2	their	-PRON-	PRP$
cord-017640-i8h48ny6	173	3	order	order	NN
cord-017640-i8h48ny6	173	4	remains	remain	VBZ
cord-017640-i8h48ny6	173	5	to	to	TO
cord-017640-i8h48ny6	173	6	be	be	VB
cord-017640-i8h48ny6	173	7	fine	fine	RB
cord-017640-i8h48ny6	173	8	-	-	HYPH
cord-017640-i8h48ny6	173	9	tuned	tune	VBN
cord-017640-i8h48ny6	173	10	,	,	,
cord-017640-i8h48ny6	173	11	these	these	DT
cord-017640-i8h48ny6	173	12	molecular	molecular	JJ
cord-017640-i8h48ny6	173	13	steps	step	NNS
cord-017640-i8h48ny6	173	14	play	play	VBP
cord-017640-i8h48ny6	173	15	a	a	DT
cord-017640-i8h48ny6	173	16	critical	critical	JJ
cord-017640-i8h48ny6	173	17	role	role	NN
cord-017640-i8h48ny6	173	18	in	in	IN
cord-017640-i8h48ny6	173	19	the	the	DT
cord-017640-i8h48ny6	173	20	implementation	implementation	NN
cord-017640-i8h48ny6	173	21	of	of	IN
cord-017640-i8h48ny6	173	22	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	173	23	signals	signal	NNS
cord-017640-i8h48ny6	173	24	.	.	.
cord-017640-i8h48ny6	174	1	Of	of	IN
cord-017640-i8h48ny6	174	2	note	note	VB
cord-017640-i8h48ny6	174	3	,	,	,
cord-017640-i8h48ny6	174	4	similar	similar	JJ
cord-017640-i8h48ny6	174	5	to	to	IN
cord-017640-i8h48ny6	174	6	S	s	NN
cord-017640-i8h48ny6	174	7	-	-	HYPH
cord-017640-i8h48ny6	174	8	nitrosylation	nitrosylation	NN
cord-017640-i8h48ny6	174	9	,	,	,
cord-017640-i8h48ny6	174	10	both	both	CC
cord-017640-i8h48ny6	174	11	the	the	DT
cord-017640-i8h48ny6	174	12	aforementioned	aforementioned	JJ
cord-017640-i8h48ny6	174	13	S	s	NN
cord-017640-i8h48ny6	174	14	-	-	HYPH
cord-017640-i8h48ny6	174	15	glutathionylation	glutathionylation	NN
cord-017640-i8h48ny6	174	16	at	at	IN
cord-017640-i8h48ny6	174	17	C304	c304	XX
cord-017640-i8h48ny6	174	18	(	(	-LRB-
cord-017640-i8h48ny6	174	19	C288	c288	$
cord-017640-i8h48ny6	174	20	)	)	-RRB-
cord-017640-i8h48ny6	174	21	and	and	CC
cord-017640-i8h48ny6	174	22	palmitoylation	palmitoylation	NN
cord-017640-i8h48ny6	174	23	at	at	IN
cord-017640-i8h48ny6	174	24	C199	C199	NNP
cord-017640-i8h48ny6	174	25	(	(	-LRB-
cord-017640-i8h48ny6	174	26	C183	C183	NNP
cord-017640-i8h48ny6	174	27	)	)	-RRB-
cord-017640-i8h48ny6	174	28	promote	promote	VB
cord-017640-i8h48ny6	174	29	the	the	DT
cord-017640-i8h48ny6	174	30	partition	partition	NN
cord-017640-i8h48ny6	174	31	of	of	IN
cord-017640-i8h48ny6	174	32	CD95	CD95	NNP
cord-017640-i8h48ny6	174	33	into	into	IN
cord-017640-i8h48ny6	174	34	lipid	lipid	NN
cord-017640-i8h48ny6	174	35	rafts	raft	NNS
cord-017640-i8h48ny6	174	36	and	and	CC
cord-017640-i8h48ny6	174	37	enhance	enhance	VB
cord-017640-i8h48ny6	174	38	the	the	DT
cord-017640-i8h48ny6	174	39	subsequent	subsequent	JJ
cord-017640-i8h48ny6	174	40	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	174	41	signal	signal	NN
cord-017640-i8h48ny6	174	42	.	.	.
cord-017640-i8h48ny6	175	1	Further	further	JJ
cord-017640-i8h48ny6	175	2	investigation	investigation	NN
cord-017640-i8h48ny6	175	3	is	be	VBZ
cord-017640-i8h48ny6	175	4	required	require	VBN
cord-017640-i8h48ny6	175	5	to	to	TO
cord-017640-i8h48ny6	175	6	address	address	VB
cord-017640-i8h48ny6	175	7	whether	whether	IN
cord-017640-i8h48ny6	175	8	these	these	DT
cord-017640-i8h48ny6	175	9	posttranslational	posttranslational	JJ
cord-017640-i8h48ny6	175	10	modifications	modification	NNS
cord-017640-i8h48ny6	175	11	are	be	VBP
cord-017640-i8h48ny6	175	12	redundant	redundant	JJ
cord-017640-i8h48ny6	175	13	and	and	CC
cord-017640-i8h48ny6	175	14	occur	occur	VBP
cord-017640-i8h48ny6	175	15	simultaneously	simultaneously	RB
cord-017640-i8h48ny6	175	16	in	in	IN
cord-017640-i8h48ny6	175	17	dying	die	VBG
cord-017640-i8h48ny6	175	18	cells	cell	NNS
cord-017640-i8h48ny6	175	19	or	or	CC
cord-017640-i8h48ny6	175	20	are	be	VBP
cord-017640-i8h48ny6	175	21	elicited	elicit	VBN
cord-017640-i8h48ny6	175	22	in	in	IN
cord-017640-i8h48ny6	175	23	a	a	DT
cord-017640-i8h48ny6	175	24	cell	cell	NN
cord-017640-i8h48ny6	175	25	-	-	HYPH
cord-017640-i8h48ny6	175	26	specific	specific	JJ
cord-017640-i8h48ny6	175	27	and/or	and/or	CC
cord-017640-i8h48ny6	175	28	in	in	IN
cord-017640-i8h48ny6	175	29	a	a	DT
cord-017640-i8h48ny6	175	30	microenvironmentspecific	microenvironmentspecific	JJ
cord-017640-i8h48ny6	175	31	manner	manner	NN
cord-017640-i8h48ny6	175	32	.	.	.
cord-017640-i8h48ny6	176	1	Understanding	understand	VBG
cord-017640-i8h48ny6	176	2	the	the	DT
cord-017640-i8h48ny6	176	3	molecular	molecular	JJ
cord-017640-i8h48ny6	176	4	mechanisms	mechanism	NNS
cord-017640-i8h48ny6	176	5	controlling	control	VBG
cord-017640-i8h48ny6	176	6	these	these	DT
cord-017640-i8h48ny6	176	7	posttranslational	posttranslational	JJ
cord-017640-i8h48ny6	176	8	modifications	modification	NNS
cord-017640-i8h48ny6	176	9	would	would	MD
cord-017640-i8h48ny6	176	10	be	be	VB
cord-017640-i8h48ny6	176	11	of	of	IN
cord-017640-i8h48ny6	176	12	great	great	JJ
cord-017640-i8h48ny6	176	13	interest	interest	NN
cord-017640-i8h48ny6	176	14	in	in	IN
cord-017640-i8h48ny6	176	15	order	order	NN
cord-017640-i8h48ny6	176	16	to	to	TO
cord-017640-i8h48ny6	176	17	identify	identify	VB
cord-017640-i8h48ny6	176	18	the	the	DT
cord-017640-i8h48ny6	176	19	mechanism	mechanism	NN
cord-017640-i8h48ny6	176	20	by	by	IN
cord-017640-i8h48ny6	176	21	which	which	WDT
cord-017640-i8h48ny6	176	22	tumor	tumor	NN
cord-017640-i8h48ny6	176	23	cells	cell	NNS
cord-017640-i8h48ny6	176	24	block	block	VBP
cord-017640-i8h48ny6	176	25	them	-PRON-	PRP
cord-017640-i8h48ny6	176	26	,	,	,
cord-017640-i8h48ny6	176	27	leading	lead	VBG
cord-017640-i8h48ny6	176	28	to	to	IN
cord-017640-i8h48ny6	176	29	their	-PRON-	PRP$
cord-017640-i8h48ny6	176	30	resistance	resistance	NN
cord-017640-i8h48ny6	176	31	to	to	IN
cord-017640-i8h48ny6	176	32	the	the	DT
cord-017640-i8h48ny6	176	33	extrinsic	extrinsic	JJ
cord-017640-i8h48ny6	176	34	signaling	signal	VBG
cord-017640-i8h48ny6	176	35	pathway	pathway	NN
cord-017640-i8h48ny6	176	36	.	.	.
cord-017640-i8h48ny6	177	1	Using	use	VBG
cord-017640-i8h48ny6	177	2	a	a	DT
cord-017640-i8h48ny6	177	3	powerful	powerful	JJ
cord-017640-i8h48ny6	177	4	magnetic	magnetic	JJ
cord-017640-i8h48ny6	177	5	method	method	NN
cord-017640-i8h48ny6	177	6	to	to	TO
cord-017640-i8h48ny6	177	7	isolate	isolate	VB
cord-017640-i8h48ny6	177	8	receptor	receptor	NN
cord-017640-i8h48ny6	177	9	-	-	HYPH
cord-017640-i8h48ny6	177	10	containing	contain	VBG
cord-017640-i8h48ny6	177	11	endocytic	endocytic	JJ
cord-017640-i8h48ny6	177	12	vesicles	vesicle	NNS
cord-017640-i8h48ny6	177	13	,	,	,
cord-017640-i8h48ny6	177	14	it	-PRON-	PRP
cord-017640-i8h48ny6	177	15	has	have	VBZ
cord-017640-i8h48ny6	177	16	been	be	VBN
cord-017640-i8h48ny6	177	17	shown	show	VBN
cord-017640-i8h48ny6	177	18	that	that	IN
cord-017640-i8h48ny6	177	19	CD95	CD95	NNP
cord-017640-i8h48ny6	177	20	promptly	promptly	RB
cord-017640-i8h48ny6	177	21	associates	associate	VBZ
cord-017640-i8h48ny6	177	22	with	with	IN
cord-017640-i8h48ny6	177	23	endosomal	endosomal	NNP
cord-017640-i8h48ny6	177	24	and	and	CC
cord-017640-i8h48ny6	177	25	lysosomal	lysosomal	JJ
cord-017640-i8h48ny6	177	26	markers	marker	NNS
cord-017640-i8h48ny6	177	27	when	when	WRB
cord-017640-i8h48ny6	177	28	incubated	incubate	VBN
cord-017640-i8h48ny6	177	29	with	with	IN
cord-017640-i8h48ny6	177	30	an	an	DT
cord-017640-i8h48ny6	177	31	agonistic	agonistic	JJ
cord-017640-i8h48ny6	177	32	anti	anti	JJ
cord-017640-i8h48ny6	177	33	-	-	JJ
cord-017640-i8h48ny6	177	34	CD95	CD95	NNP
cord-017640-i8h48ny6	177	35	mAb	mAb	.
cord-017640-i8h48ny6	177	36	[	[	-LRB-
cord-017640-i8h48ny6	177	37	126	126	CD
cord-017640-i8h48ny6	177	38	]	]	-RRB-
cord-017640-i8h48ny6	177	39	.	.	.
cord-017640-i8h48ny6	178	1	In	in	IN
cord-017640-i8h48ny6	178	2	addition	addition	NN
cord-017640-i8h48ny6	178	3	,	,	,
cord-017640-i8h48ny6	178	4	expression	expression	NN
cord-017640-i8h48ny6	178	5	of	of	IN
cord-017640-i8h48ny6	178	6	a	a	DT
cord-017640-i8h48ny6	178	7	CD95	CD95	NNP
cord-017640-i8h48ny6	178	8	mutant	mutant	JJ
cord-017640-i8h48ny6	178	9	in	in	IN
cord-017640-i8h48ny6	178	10	which	which	WDT
cord-017640-i8h48ny6	178	11	the	the	DT
cord-017640-i8h48ny6	178	12	DD	DD	NNP
cord-017640-i8h48ny6	178	13	-	-	HYPH
cord-017640-i8h48ny6	178	14	located	locate	VBN
cord-017640-i8h48ny6	178	15	tyrosine	tyrosine	NN
cord-017640-i8h48ny6	178	16	291	291	CD
cord-017640-i8h48ny6	178	17	(	(	-LRB-
cord-017640-i8h48ny6	178	18	Y275	Y275	NNP
cord-017640-i8h48ny6	178	19	)	)	-RRB-
cord-017640-i8h48ny6	178	20	is	be	VBZ
cord-017640-i8h48ny6	178	21	changed	change	VBN
cord-017640-i8h48ny6	178	22	to	to	IN
cord-017640-i8h48ny6	178	23	phenylalanine	phenylalanine	NN
cord-017640-i8h48ny6	178	24	does	do	VBZ
cord-017640-i8h48ny6	178	25	not	not	RB
cord-017640-i8h48ny6	178	26	seem	seem	VB
cord-017640-i8h48ny6	178	27	to	to	TO
cord-017640-i8h48ny6	178	28	alter	alter	VB
cord-017640-i8h48ny6	178	29	the	the	DT
cord-017640-i8h48ny6	178	30	capacity	capacity	NN
cord-017640-i8h48ny6	178	31	to	to	TO
cord-017640-i8h48ny6	178	32	bind	bind	VB
cord-017640-i8h48ny6	178	33	FADD	FADD	NNP
cord-017640-i8h48ny6	178	34	but	but	CC
cord-017640-i8h48ny6	178	35	compromises	compromise	NNS
cord-017640-i8h48ny6	178	36	CD95L	cd95l	NN
cord-017640-i8h48ny6	178	37	-	-	HYPH
cord-017640-i8h48ny6	178	38	mediated	mediate	VBN
cord-017640-i8h48ny6	178	39	CD95	CD95	NNP
cord-017640-i8h48ny6	178	40	internalization	internalization	NN
cord-017640-i8h48ny6	178	41	occurring	occur	VBG
cord-017640-i8h48ny6	178	42	through	through	IN
cord-017640-i8h48ny6	178	43	an	an	DT
cord-017640-i8h48ny6	178	44	AP2	AP2	NNP
cord-017640-i8h48ny6	178	45	/	/	SYM
cord-017640-i8h48ny6	178	46	clathrin	clathrin	NN
cord-017640-i8h48ny6	178	47	-	-	HYPH
cord-017640-i8h48ny6	178	48	driven	drive	VBN
cord-017640-i8h48ny6	178	49	endocytic	endocytic	JJ
cord-017640-i8h48ny6	178	50	pathway	pathway	NN
cord-017640-i8h48ny6	178	51	[	[	-LRB-
cord-017640-i8h48ny6	178	52	126	126	CD
cord-017640-i8h48ny6	178	53	]	]	-RRB-
cord-017640-i8h48ny6	178	54	.	.	.
cord-017640-i8h48ny6	179	1	More	more	RBR
cord-017640-i8h48ny6	179	2	strikingly	strikingly	RB
cord-017640-i8h48ny6	179	3	,	,	,
cord-017640-i8h48ny6	179	4	expression	expression	NN
cord-017640-i8h48ny6	179	5	of	of	IN
cord-017640-i8h48ny6	179	6	the	the	DT
cord-017640-i8h48ny6	179	7	internalization	internalization	NN
cord-017640-i8h48ny6	179	8	-	-	HYPH
cord-017640-i8h48ny6	179	9	defective	defective	JJ
cord-017640-i8h48ny6	179	10	CD95	CD95	NNP
cord-017640-i8h48ny6	179	11	mutant	mutant	JJ
cord-017640-i8h48ny6	179	12	Y291F	Y291F	NNP
cord-017640-i8h48ny6	179	13	abrogates	abrogate	VBZ
cord-017640-i8h48ny6	179	14	the	the	DT
cord-017640-i8h48ny6	179	15	transmission	transmission	NN
cord-017640-i8h48ny6	179	16	of	of	IN
cord-017640-i8h48ny6	179	17	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	179	18	signals	signal	NNS
cord-017640-i8h48ny6	179	19	,	,	,
cord-017640-i8h48ny6	179	20	but	but	CC
cord-017640-i8h48ny6	179	21	fails	fail	VBZ
cord-017640-i8h48ny6	179	22	to	to	TO
cord-017640-i8h48ny6	179	23	alter	alter	VB
cord-017640-i8h48ny6	179	24	the	the	DT
cord-017640-i8h48ny6	179	25	non	non	JJ
cord-017640-i8h48ny6	179	26	-	-	JJ
cord-017640-i8h48ny6	179	27	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	179	28	signaling	signal	VBG
cord-017640-i8h48ny6	179	29	pathways	pathway	NNS
cord-017640-i8h48ny6	179	30	(	(	-LRB-
cord-017640-i8h48ny6	179	31	i.e.	i.e.	FW
cord-017640-i8h48ny6	179	32	,	,	,
cord-017640-i8h48ny6	179	33	NF	NF	NNP
cord-017640-i8h48ny6	179	34	-	-	HYPH
cord-017640-i8h48ny6	179	35	κB	κB	NNP
cord-017640-i8h48ny6	179	36	and	and	CC
cord-017640-i8h48ny6	179	37	ERK	ERK	NNP
cord-017640-i8h48ny6	179	38	)	)	-RRB-
cord-017640-i8h48ny6	179	39	,	,	,
cord-017640-i8h48ny6	179	40	and	and	CC
cord-017640-i8h48ny6	179	41	even	even	RB
cord-017640-i8h48ny6	179	42	promotes	promote	VBZ
cord-017640-i8h48ny6	179	43	them	-PRON-	PRP
cord-017640-i8h48ny6	179	44	(	(	-LRB-
cord-017640-i8h48ny6	179	45	Fig	Fig	NNP
cord-017640-i8h48ny6	179	46	.	.	.
cord-017640-i8h48ny6	179	47	11.3	11.3	CD
cord-017640-i8h48ny6	179	48	)	)	-RRB-
cord-017640-i8h48ny6	179	49	.	.	.
cord-017640-i8h48ny6	180	1	These	these	DT
cord-017640-i8h48ny6	180	2	findings	finding	NNS
cord-017640-i8h48ny6	180	3	provide	provide	VBP
cord-017640-i8h48ny6	180	4	insight	insight	NN
cord-017640-i8h48ny6	180	5	into	into	IN
cord-017640-i8h48ny6	180	6	the	the	DT
cord-017640-i8h48ny6	180	7	presence	presence	NN
cord-017640-i8h48ny6	180	8	of	of	IN
cord-017640-i8h48ny6	180	9	a	a	DT
cord-017640-i8h48ny6	180	10	region	region	NN
cord-017640-i8h48ny6	180	11	in	in	IN
cord-017640-i8h48ny6	180	12	the	the	DT
cord-017640-i8h48ny6	180	13	DD	DD	NNP
cord-017640-i8h48ny6	180	14	,	,	,
cord-017640-i8h48ny6	180	15	interacting	interact	VBG
cord-017640-i8h48ny6	180	16	with	with	IN
cord-017640-i8h48ny6	180	17	AP2	AP2	NNP
cord-017640-i8h48ny6	180	18	and	and	CC
cord-017640-i8h48ny6	180	19	promoting	promote	VBG
cord-017640-i8h48ny6	180	20	a	a	DT
cord-017640-i8h48ny6	180	21	clathrin	clathrin	NN
cord-017640-i8h48ny6	180	22	-	-	HYPH
cord-017640-i8h48ny6	180	23	dependent	dependent	JJ
cord-017640-i8h48ny6	180	24	endocytic	endocytic	JJ
cord-017640-i8h48ny6	180	25	pathway	pathway	NN
cord-017640-i8h48ny6	180	26	in	in	IN
cord-017640-i8h48ny6	180	27	a	a	DT
cord-017640-i8h48ny6	180	28	FADD	FADD	NNP
cord-017640-i8h48ny6	180	29	-	-	HYPH
cord-017640-i8h48ny6	180	30	independent	independent	JJ
cord-017640-i8h48ny6	180	31	manner	manner	NN
cord-017640-i8h48ny6	180	32	.	.	.
cord-017640-i8h48ny6	181	1	Regarding	regard	VBG
cord-017640-i8h48ny6	181	2	the	the	DT
cord-017640-i8h48ny6	181	3	role	role	NN
cord-017640-i8h48ny6	181	4	of	of	IN
cord-017640-i8h48ny6	181	5	palmitoylation	palmitoylation	NN
cord-017640-i8h48ny6	181	6	in	in	IN
cord-017640-i8h48ny6	181	7	receptor	receptor	NN
cord-017640-i8h48ny6	181	8	internalization	internalization	NN
cord-017640-i8h48ny6	181	9	,	,	,
cord-017640-i8h48ny6	181	10	the	the	DT
cord-017640-i8h48ny6	181	11	interplay	interplay	NN
cord-017640-i8h48ny6	181	12	between	between	IN
cord-017640-i8h48ny6	181	13	lipid	lipid	NN
cord-017640-i8h48ny6	181	14	alteration	alteration	NN
cord-017640-i8h48ny6	181	15	and	and	CC
cord-017640-i8h48ny6	181	16	the	the	DT
cord-017640-i8h48ny6	181	17	AP2	AP2	NNP
cord-017640-i8h48ny6	181	18	/	/	SYM
cord-017640-i8h48ny6	181	19	clathrin	clathrin	NN
cord-017640-i8h48ny6	181	20	-	-	HYPH
cord-017640-i8h48ny6	181	21	driven	drive	VBN
cord-017640-i8h48ny6	181	22	internalization	internalization	NN
cord-017640-i8h48ny6	181	23	of	of	IN
cord-017640-i8h48ny6	181	24	CD95	CD95	NNP
cord-017640-i8h48ny6	181	25	remains	remain	VBZ
cord-017640-i8h48ny6	181	26	to	to	TO
cord-017640-i8h48ny6	181	27	be	be	VB
cord-017640-i8h48ny6	181	28	elucidated	elucidate	VBN
cord-017640-i8h48ny6	181	29	.	.	.
cord-017640-i8h48ny6	182	1	It	-PRON-	PRP
cord-017640-i8h48ny6	182	2	has	have	VBZ
cord-017640-i8h48ny6	182	3	been	be	VBN
cord-017640-i8h48ny6	182	4	recently	recently	RB
cord-017640-i8h48ny6	182	5	demonstrated	demonstrate	VBN
cord-017640-i8h48ny6	182	6	that	that	IN
cord-017640-i8h48ny6	182	7	CD95	CD95	NNP
cord-017640-i8h48ny6	182	8	engagement	engagement	NN
cord-017640-i8h48ny6	182	9	evokes	evoke	VBZ
cord-017640-i8h48ny6	182	10	a	a	DT
cord-017640-i8h48ny6	182	11	rapid	rapid	JJ
cord-017640-i8h48ny6	182	12	and	and	CC
cord-017640-i8h48ny6	182	13	transient	transient	JJ
cord-017640-i8h48ny6	182	14	Ca	Ca	NNP
cord-017640-i8h48ny6	182	15	2	2	CD
cord-017640-i8h48ny6	182	16	+	+	SYM
cord-017640-i8h48ny6	182	17	signaling	signaling	NN
cord-017640-i8h48ny6	182	18	,	,	,
cord-017640-i8h48ny6	182	19	which	which	WDT
cord-017640-i8h48ny6	182	20	stimulates	stimulate	VBZ
cord-017640-i8h48ny6	182	21	the	the	DT
cord-017640-i8h48ny6	182	22	recruitment	recruitment	NN
cord-017640-i8h48ny6	182	23	of	of	IN
cord-017640-i8h48ny6	182	24	protein	protein	NN
cord-017640-i8h48ny6	182	25	kinase	kinase	NN
cord-017640-i8h48ny6	182	26	C	C	NNP
cord-017640-i8h48ny6	182	27	-	-	HYPH
cord-017640-i8h48ny6	182	28	β2	β2	NNP
cord-017640-i8h48ny6	182	29	(	(	-LRB-
cord-017640-i8h48ny6	182	30	PKC	PKC	NNP
cord-017640-i8h48ny6	182	31	-	-	HYPH
cord-017640-i8h48ny6	182	32	β2	β2	NNP
cord-017640-i8h48ny6	182	33	)	)	-RRB-
cord-017640-i8h48ny6	182	34	from	from	IN
cord-017640-i8h48ny6	182	35	the	the	DT
cord-017640-i8h48ny6	182	36	cytosol	cytosol	NN
cord-017640-i8h48ny6	182	37	to	to	IN
cord-017640-i8h48ny6	182	38	the	the	DT
cord-017640-i8h48ny6	182	39	DISC	disc	NN
cord-017640-i8h48ny6	182	40	[	[	-LRB-
cord-017640-i8h48ny6	182	41	127	127	CD
cord-017640-i8h48ny6	182	42	]	]	-RRB-
cord-017640-i8h48ny6	182	43	.	.	.
cord-017640-i8h48ny6	183	1	This	this	DT
cord-017640-i8h48ny6	183	2	kinase	kinase	NN
cord-017640-i8h48ny6	183	3	transiently	transiently	RB
cord-017640-i8h48ny6	183	4	brakes	brake	VBZ
cord-017640-i8h48ny6	183	5	DISC	disc	NN
cord-017640-i8h48ny6	183	6	formation	formation	NN
cord-017640-i8h48ny6	183	7	,	,	,
cord-017640-i8h48ny6	183	8	providing	provide	VBG
cord-017640-i8h48ny6	183	9	a	a	DT
cord-017640-i8h48ny6	183	10	checkpoint	checkpoint	NN
cord-017640-i8h48ny6	183	11	before	before	IN
cord-017640-i8h48ny6	183	12	the	the	DT
cord-017640-i8h48ny6	183	13	irreversible	irreversible	JJ
cord-017640-i8h48ny6	183	14	commitment	commitment	NN
cord-017640-i8h48ny6	183	15	to	to	IN
cord-017640-i8h48ny6	183	16	cell	cell	NN
cord-017640-i8h48ny6	183	17	death	death	NN
cord-017640-i8h48ny6	183	18	[	[	-LRB-
cord-017640-i8h48ny6	183	19	128	128	CD
cord-017640-i8h48ny6	183	20	]	]	-RRB-
cord-017640-i8h48ny6	183	21	.	.	.
cord-017640-i8h48ny6	184	1	These	these	DT
cord-017640-i8h48ny6	184	2	findings	finding	NNS
cord-017640-i8h48ny6	184	3	raised	raise	VBD
cord-017640-i8h48ny6	184	4	the	the	DT
cord-017640-i8h48ny6	184	5	following	follow	VBG
cord-017640-i8h48ny6	184	6	questions	question	NNS
cord-017640-i8h48ny6	184	7	:	:	:
cord-017640-i8h48ny6	184	8	what	what	WP
cord-017640-i8h48ny6	184	9	are	be	VBP
cord-017640-i8h48ny6	184	10	the	the	DT
cord-017640-i8h48ny6	184	11	Ca	Ca	NNP
cord-017640-i8h48ny6	184	12	2	2	CD
cord-017640-i8h48ny6	185	1	+	+	CC
cord-017640-i8h48ny6	185	2	-dependent	-dependent	JJ
cord-017640-i8h48ny6	185	3	molecular	molecular	JJ
cord-017640-i8h48ny6	185	4	mechanisms	mechanism	NNS
cord-017640-i8h48ny6	185	5	transiently	transiently	RB
cord-017640-i8h48ny6	185	6	inhibiting	inhibit	VBG
cord-017640-i8h48ny6	185	7	DISC	disc	NN
cord-017640-i8h48ny6	185	8	formation	formation	NN
cord-017640-i8h48ny6	185	9	,	,	,
cord-017640-i8h48ny6	185	10	and	and	CC
cord-017640-i8h48ny6	185	11	do	do	VB
cord-017640-i8h48ny6	185	12	tumor	tumor	NN
cord-017640-i8h48ny6	185	13	cells	cell	NNS
cord-017640-i8h48ny6	185	14	use	use	VBP
cord-017640-i8h48ny6	185	15	this	this	DT
cord-017640-i8h48ny6	185	16	signal	signal	NN
cord-017640-i8h48ny6	185	17	to	to	TO
cord-017640-i8h48ny6	185	18	escape	escape	VB
cord-017640-i8h48ny6	185	19	the	the	DT
cord-017640-i8h48ny6	185	20	immune	immune	JJ
cord-017640-i8h48ny6	185	21	response	response	NN
cord-017640-i8h48ny6	185	22	and/or	and/or	CC
cord-017640-i8h48ny6	185	23	resist	resist	VBP
cord-017640-i8h48ny6	185	24	chemotherapy	chemotherapy	NN
cord-017640-i8h48ny6	185	25	?	?	.
cord-017640-i8h48ny6	186	1	In	in	IN
cord-017640-i8h48ny6	186	2	1998	1998	CD
cord-017640-i8h48ny6	186	3	,	,	,
cord-017640-i8h48ny6	186	4	inhibition	inhibition	NN
cord-017640-i8h48ny6	186	5	of	of	IN
cord-017640-i8h48ny6	186	6	caspase	caspase	NN
cord-017640-i8h48ny6	186	7	activity	activity	NN
cord-017640-i8h48ny6	186	8	was	be	VBD
cord-017640-i8h48ny6	186	9	shown	show	VBN
cord-017640-i8h48ny6	186	10	to	to	TO
cord-017640-i8h48ny6	186	11	sensitize	sensitize	VB
cord-017640-i8h48ny6	186	12	fibroblastic	fibroblastic	JJ
cord-017640-i8h48ny6	186	13	L929	l929	JJ
cord-017640-i8h48ny6	186	14	cell	cell	NN
cord-017640-i8h48ny6	186	15	line	line	NN
cord-017640-i8h48ny6	186	16	to	to	IN
cord-017640-i8h48ny6	186	17	TNFmediated	tnfmediated	JJ
cord-017640-i8h48ny6	186	18	necrotic	necrotic	JJ
cord-017640-i8h48ny6	186	19	cell	cell	NN
cord-017640-i8h48ny6	186	20	death	death	NN
cord-017640-i8h48ny6	186	21	[	[	-LRB-
cord-017640-i8h48ny6	186	22	42	42	CD
cord-017640-i8h48ny6	186	23	]	]	-RRB-
cord-017640-i8h48ny6	186	24	.	.	.
cord-017640-i8h48ny6	187	1	With	with	IN
cord-017640-i8h48ny6	187	2	respect	respect	NN
cord-017640-i8h48ny6	187	3	to	to	IN
cord-017640-i8h48ny6	187	4	CD95	CD95	NNP
cord-017640-i8h48ny6	187	5	signal	signal	NN
cord-017640-i8h48ny6	187	6	,	,	,
cord-017640-i8h48ny6	187	7	Tschopp	Tschopp	NNP
cord-017640-i8h48ny6	187	8	et	et	NNP
cord-017640-i8h48ny6	187	9	al	al	NNP
cord-017640-i8h48ny6	187	10	.	.	NNP
cord-017640-i8h48ny6	187	11	showed	show	VBD
cord-017640-i8h48ny6	187	12	that	that	IN
cord-017640-i8h48ny6	187	13	FADD	FADD	NNP
cord-017640-i8h48ny6	187	14	and	and	CC
cord-017640-i8h48ny6	187	15	RIP1	RIP1	NNP
cord-017640-i8h48ny6	187	16	participate	participate	VBP
cord-017640-i8h48ny6	187	17	in	in	IN
cord-017640-i8h48ny6	187	18	the	the	DT
cord-017640-i8h48ny6	187	19	implementation	implementation	NN
cord-017640-i8h48ny6	187	20	of	of	IN
cord-017640-i8h48ny6	187	21	a	a	DT
cord-017640-i8h48ny6	187	22	non	non	JJ
cord-017640-i8h48ny6	187	23	-	-	JJ
cord-017640-i8h48ny6	187	24	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	187	25	signaling	signal	VBG
cord-017640-i8h48ny6	187	26	pathway	pathway	NN
cord-017640-i8h48ny6	187	27	,	,	,
cord-017640-i8h48ny6	187	28	which	which	WDT
cord-017640-i8h48ny6	187	29	leads	lead	VBZ
cord-017640-i8h48ny6	187	30	to	to	IN
cord-017640-i8h48ny6	187	31	a	a	DT
cord-017640-i8h48ny6	187	32	necrotic	necrotic	JJ
cord-017640-i8h48ny6	187	33	morphology	morphology	NN
cord-017640-i8h48ny6	187	34	without	without	IN
cord-017640-i8h48ny6	187	35	chromatin	chromatin	NN
cord-017640-i8h48ny6	187	36	condensation	condensation	NN
cord-017640-i8h48ny6	187	37	and	and	CC
cord-017640-i8h48ny6	187	38	with	with	IN
cord-017640-i8h48ny6	187	39	loss	loss	NN
cord-017640-i8h48ny6	187	40	of	of	IN
cord-017640-i8h48ny6	187	41	plasma	plasma	NN
cord-017640-i8h48ny6	187	42	membrane	membrane	NN
cord-017640-i8h48ny6	187	43	integrity	integrity	NN
cord-017640-i8h48ny6	187	44	[	[	-LRB-
cord-017640-i8h48ny6	187	45	41	41	CD
cord-017640-i8h48ny6	187	46	]	]	-RRB-
cord-017640-i8h48ny6	187	47	.	.	.
cord-017640-i8h48ny6	188	1	Of	of	IN
cord-017640-i8h48ny6	188	2	note	note	NN
cord-017640-i8h48ny6	188	3	,	,	,
cord-017640-i8h48ny6	188	4	BID	BID	VBN
cord-017640-i8h48ny6	188	5	cleavage	cleavage	NN
cord-017640-i8h48ny6	188	6	was	be	VBD
cord-017640-i8h48ny6	188	7	not	not	RB
cord-017640-i8h48ny6	188	8	observed	observe	VBN
cord-017640-i8h48ny6	188	9	in	in	IN
cord-017640-i8h48ny6	188	10	this	this	DT
cord-017640-i8h48ny6	188	11	necrotic	necrotic	JJ
cord-017640-i8h48ny6	188	12	signal	signal	NN
cord-017640-i8h48ny6	188	13	.	.	.
cord-017640-i8h48ny6	189	1	While	while	IN
cord-017640-i8h48ny6	189	2	FADD	FADD	NNP
cord-017640-i8h48ny6	189	3	plays	play	VBZ
cord-017640-i8h48ny6	189	4	a	a	DT
cord-017640-i8h48ny6	189	5	crucial	crucial	JJ
cord-017640-i8h48ny6	189	6	role	role	NN
cord-017640-i8h48ny6	189	7	in	in	IN
cord-017640-i8h48ny6	189	8	both	both	CC
cord-017640-i8h48ny6	189	9	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	189	10	and	and	CC
cord-017640-i8h48ny6	189	11	necrotic	necrotic	JJ
cord-017640-i8h48ny6	189	12	pathways	pathway	NNS
cord-017640-i8h48ny6	189	13	,	,	,
cord-017640-i8h48ny6	189	14	RIP1	rip1	NN
cord-017640-i8h48ny6	189	15	recruitment	recruitment	NN
cord-017640-i8h48ny6	189	16	to	to	IN
cord-017640-i8h48ny6	189	17	CD95	CD95	NNP
cord-017640-i8h48ny6	189	18	occurs	occur	VBZ
cord-017640-i8h48ny6	189	19	independently	independently	RB
cord-017640-i8h48ny6	189	20	of	of	IN
cord-017640-i8h48ny6	189	21	this	this	DT
cord-017640-i8h48ny6	189	22	adaptor	adaptor	NN
cord-017640-i8h48ny6	189	23	protein	protein	NN
cord-017640-i8h48ny6	189	24	.	.	.
cord-017640-i8h48ny6	190	1	Indeed	indeed	RB
cord-017640-i8h48ny6	190	2	,	,	,
cord-017640-i8h48ny6	190	3	yeast	yeast	VB
cord-017640-i8h48ny6	190	4	two	two	CD
cord-017640-i8h48ny6	190	5	-	-	HYPH
cord-017640-i8h48ny6	190	6	hybrid	hybrid	NN
cord-017640-i8h48ny6	190	7	experiments	experiment	NNS
cord-017640-i8h48ny6	190	8	showed	show	VBD
cord-017640-i8h48ny6	190	9	that	that	IN
cord-017640-i8h48ny6	190	10	RIP1	RIP1	NNP
cord-017640-i8h48ny6	190	11	can	can	MD
cord-017640-i8h48ny6	190	12	bind	bind	VB
cord-017640-i8h48ny6	190	13	directly	directly	RB
cord-017640-i8h48ny6	190	14	to	to	IN
cord-017640-i8h48ny6	190	15	the	the	DT
cord-017640-i8h48ny6	190	16	CD95-DD	cd95-dd	NN
cord-017640-i8h48ny6	190	17	,	,	,
cord-017640-i8h48ny6	190	18	while	while	IN
cord-017640-i8h48ny6	190	19	this	this	DT
cord-017640-i8h48ny6	190	20	interaction	interaction	NN
cord-017640-i8h48ny6	190	21	is	be	VBZ
cord-017640-i8h48ny6	190	22	lost	lose	VBN
cord-017640-i8h48ny6	190	23	when	when	WRB
cord-017640-i8h48ny6	190	24	a	a	DT
cord-017640-i8h48ny6	190	25	bait	bait	NN
cord-017640-i8h48ny6	190	26	corresponding	correspond	VBG
cord-017640-i8h48ny6	190	27	to	to	IN
cord-017640-i8h48ny6	190	28	mutated	mutate	VBN
cord-017640-i8h48ny6	190	29	CD95-DD	cd95-dd	NN
cord-017640-i8h48ny6	190	30	(	(	-LRB-
cord-017640-i8h48ny6	190	31	replacement	replacement	NN
cord-017640-i8h48ny6	190	32	of	of	IN
cord-017640-i8h48ny6	190	33	Val	Val	NNP
cord-017640-i8h48ny6	190	34	238	238	CD
cord-017640-i8h48ny6	190	35	to	to	IN
cord-017640-i8h48ny6	190	36	Asn	Asn	NNP
cord-017640-i8h48ny6	190	37	)	)	-RRB-
cord-017640-i8h48ny6	190	38	is	be	VBZ
cord-017640-i8h48ny6	190	39	used	use	VBN
cord-017640-i8h48ny6	190	40	[	[	-LRB-
cord-017640-i8h48ny6	190	41	129	129	CD
cord-017640-i8h48ny6	190	42	]	]	-RRB-
cord-017640-i8h48ny6	190	43	.	.	.
cord-017640-i8h48ny6	191	1	In	in	IN
cord-017640-i8h48ny6	191	2	addition	addition	NN
cord-017640-i8h48ny6	191	3	,	,	,
cord-017640-i8h48ny6	191	4	RIP3	RIP3	NNP
cord-017640-i8h48ny6	191	5	(	(	-LRB-
cord-017640-i8h48ny6	191	6	RIPK3	RIPK3	NNP
cord-017640-i8h48ny6	191	7	,	,	,
cord-017640-i8h48ny6	191	8	a	a	DT
cord-017640-i8h48ny6	191	9	member	member	NN
cord-017640-i8h48ny6	191	10	of	of	IN
cord-017640-i8h48ny6	191	11	the	the	DT
cord-017640-i8h48ny6	191	12	RIP	RIP	NNP
cord-017640-i8h48ny6	191	13	kinase	kinase	NNP
cord-017640-i8h48ny6	191	14	family	family	NN
cord-017640-i8h48ny6	191	15	)	)	-RRB-
cord-017640-i8h48ny6	191	16	is	be	VBZ
cord-017640-i8h48ny6	191	17	an	an	DT
cord-017640-i8h48ny6	191	18	indispensable	indispensable	JJ
cord-017640-i8h48ny6	191	19	factor	factor	NN
cord-017640-i8h48ny6	191	20	for	for	IN
cord-017640-i8h48ny6	191	21	the	the	DT
cord-017640-i8h48ny6	191	22	induction	induction	NN
cord-017640-i8h48ny6	191	23	of	of	IN
cord-017640-i8h48ny6	191	24	the	the	DT
cord-017640-i8h48ny6	191	25	necrotic	necrotic	JJ
cord-017640-i8h48ny6	191	26	signaling	signal	VBG
cord-017640-i8h48ny6	191	27	pathway	pathway	NN
cord-017640-i8h48ny6	191	28	[	[	-LRB-
cord-017640-i8h48ny6	191	29	78	78	CD
cord-017640-i8h48ny6	191	30	]	]	-RRB-
cord-017640-i8h48ny6	191	31	[	[	-LRB-
cord-017640-i8h48ny6	191	32	79	79	CD
cord-017640-i8h48ny6	191	33	]	]	-RRB-
cord-017640-i8h48ny6	191	34	[	[	-LRB-
cord-017640-i8h48ny6	191	35	80	80	CD
cord-017640-i8h48ny6	191	36	]	]	-RRB-
cord-017640-i8h48ny6	191	37	.	.	.
cord-017640-i8h48ny6	192	1	A	a	DT
cord-017640-i8h48ny6	192	2	growing	grow	VBG
cord-017640-i8h48ny6	192	3	body	body	NN
cord-017640-i8h48ny6	192	4	of	of	IN
cord-017640-i8h48ny6	192	5	evidence	evidence	NN
cord-017640-i8h48ny6	192	6	supports	support	VBZ
cord-017640-i8h48ny6	192	7	the	the	DT
cord-017640-i8h48ny6	192	8	existence	existence	NN
cord-017640-i8h48ny6	192	9	of	of	IN
cord-017640-i8h48ny6	192	10	necroptosis	necroptosis	NNP
cord-017640-i8h48ny6	192	11	(	(	-LRB-
cord-017640-i8h48ny6	192	12	programmed	program	VBN
cord-017640-i8h48ny6	192	13	necrosis	necrosis	NN
cord-017640-i8h48ny6	192	14	)	)	-RRB-
cord-017640-i8h48ny6	192	15	.	.	.
cord-017640-i8h48ny6	193	1	In	in	IN
cord-017640-i8h48ny6	193	2	addition	addition	NN
cord-017640-i8h48ny6	193	3	,	,	,
cord-017640-i8h48ny6	193	4	identification	identification	NN
cord-017640-i8h48ny6	193	5	of	of	IN
cord-017640-i8h48ny6	193	6	necrostatin	necrostatin	NN
cord-017640-i8h48ny6	193	7	,	,	,
cord-017640-i8h48ny6	193	8	a	a	DT
cord-017640-i8h48ny6	193	9	chemical	chemical	JJ
cord-017640-i8h48ny6	193	10	inhibitor	inhibitor	NN
cord-017640-i8h48ny6	193	11	of	of	IN
cord-017640-i8h48ny6	193	12	necroptosis	necroptosis	NNP
cord-017640-i8h48ny6	193	13	[	[	-LRB-
cord-017640-i8h48ny6	193	14	130	130	CD
cord-017640-i8h48ny6	193	15	]	]	-RRB-
cord-017640-i8h48ny6	193	16	,	,	,
cord-017640-i8h48ny6	193	17	which	which	WDT
cord-017640-i8h48ny6	193	18	specifically	specifically	RB
cord-017640-i8h48ny6	193	19	inhibits	inhibit	VBZ
cord-017640-i8h48ny6	193	20	RIP1	rip1	NN
cord-017640-i8h48ny6	193	21	kinase	kinase	NN
cord-017640-i8h48ny6	193	22	activity	activity	NN
cord-017640-i8h48ny6	193	23	[	[	-LRB-
cord-017640-i8h48ny6	193	24	131	131	CD
cord-017640-i8h48ny6	193	25	]	]	-RRB-
cord-017640-i8h48ny6	193	26	,	,	,
cord-017640-i8h48ny6	193	27	has	have	VBZ
cord-017640-i8h48ny6	193	28	accelerated	accelerate	VBN
cord-017640-i8h48ny6	193	29	the	the	DT
cord-017640-i8h48ny6	193	30	pace	pace	NN
cord-017640-i8h48ny6	193	31	of	of	IN
cord-017640-i8h48ny6	193	32	discovery	discovery	NN
cord-017640-i8h48ny6	193	33	in	in	IN
cord-017640-i8h48ny6	193	34	this	this	DT
cord-017640-i8h48ny6	193	35	field	field	NN
cord-017640-i8h48ny6	193	36	of	of	IN
cord-017640-i8h48ny6	193	37	cell	cell	NN
cord-017640-i8h48ny6	193	38	death	death	NN
cord-017640-i8h48ny6	193	39	.	.	.
cord-017640-i8h48ny6	194	1	Interplays	interplay	NNS
cord-017640-i8h48ny6	194	2	exist	exist	VBP
cord-017640-i8h48ny6	194	3	between	between	IN
cord-017640-i8h48ny6	194	4	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	194	5	and	and	CC
cord-017640-i8h48ny6	194	6	necroptosis	necroptosis	NN
cord-017640-i8h48ny6	194	7	;	;	:
cord-017640-i8h48ny6	194	8	for	for	IN
cord-017640-i8h48ny6	194	9	instance	instance	NN
cord-017640-i8h48ny6	194	10	,	,	,
cord-017640-i8h48ny6	194	11	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	194	12	,	,	,
cord-017640-i8h48ny6	194	13	a	a	DT
cord-017640-i8h48ny6	194	14	potent	potent	JJ
cord-017640-i8h48ny6	194	15	inhibitor	inhibitor	NN
cord-017640-i8h48ny6	194	16	of	of	IN
cord-017640-i8h48ny6	194	17	necroptosis	necroptosis	NN
cord-017640-i8h48ny6	194	18	for	for	IN
cord-017640-i8h48ny6	194	19	both	both	DT
cord-017640-i8h48ny6	194	20	CD95	CD95	NNP
cord-017640-i8h48ny6	194	21	and	and	CC
cord-017640-i8h48ny6	195	1	TNFR1	TNFR1	NNP
cord-017640-i8h48ny6	195	2	[	[	-LRB-
cord-017640-i8h48ny6	195	3	132	132	CD
cord-017640-i8h48ny6	195	4	]	]	-RRB-
cord-017640-i8h48ny6	195	5	,	,	,
cord-017640-i8h48ny6	195	6	plays	play	VBZ
cord-017640-i8h48ny6	195	7	a	a	DT
cord-017640-i8h48ny6	195	8	critical	critical	JJ
cord-017640-i8h48ny6	195	9	role	role	NN
cord-017640-i8h48ny6	195	10	in	in	IN
cord-017640-i8h48ny6	195	11	necroptosis	necroptosis	NNP
cord-017640-i8h48ny6	195	12	by	by	IN
cord-017640-i8h48ny6	195	13	its	-PRON-	PRP$
cord-017640-i8h48ny6	195	14	ability	ability	NN
cord-017640-i8h48ny6	195	15	to	to	TO
cord-017640-i8h48ny6	195	16	process	process	VB
cord-017640-i8h48ny6	195	17	and	and	CC
cord-017640-i8h48ny6	195	18	inactivate	inactivate	VB
cord-017640-i8h48ny6	195	19	RIP1	RIP1	NNP
cord-017640-i8h48ny6	195	20	and	and	CC
cord-017640-i8h48ny6	195	21	RIP3	RIP3	NNPS
cord-017640-i8h48ny6	195	22	[	[	-LRB-
cord-017640-i8h48ny6	195	23	133	133	CD
cord-017640-i8h48ny6	195	24	,	,	,
cord-017640-i8h48ny6	195	25	134	134	CD
cord-017640-i8h48ny6	195	26	]	]	-RRB-
cord-017640-i8h48ny6	195	27	.	.	.
cord-017640-i8h48ny6	196	1	At	at	IN
cord-017640-i8h48ny6	196	2	least	least	JJS
cord-017640-i8h48ny6	196	3	for	for	IN
cord-017640-i8h48ny6	197	1	TNF	TNF	NNP
cord-017640-i8h48ny6	197	2	signaling	signaling	NN
cord-017640-i8h48ny6	197	3	,	,	,
cord-017640-i8h48ny6	197	4	the	the	DT
cord-017640-i8h48ny6	197	5	necrotic	necrotic	JJ
cord-017640-i8h48ny6	197	6	signal	signal	NN
cord-017640-i8h48ny6	197	7	relies	rely	VBZ
cord-017640-i8h48ny6	197	8	on	on	IN
cord-017640-i8h48ny6	197	9	the	the	DT
cord-017640-i8h48ny6	197	10	activity	activity	NN
cord-017640-i8h48ny6	197	11	of	of	IN
cord-017640-i8h48ny6	197	12	CYLD	CYLD	NNP
cord-017640-i8h48ny6	197	13	,	,	,
cord-017640-i8h48ny6	197	14	a	a	DT
cord-017640-i8h48ny6	197	15	deubiquitinating	deubiquitinating	NN
cord-017640-i8h48ny6	197	16	enzyme	enzyme	NN
cord-017640-i8h48ny6	197	17	that	that	WDT
cord-017640-i8h48ny6	197	18	is	be	VBZ
cord-017640-i8h48ny6	197	19	also	also	RB
cord-017640-i8h48ny6	197	20	cleaved	cleave	VBN
cord-017640-i8h48ny6	197	21	and	and	CC
cord-017640-i8h48ny6	197	22	inactivated	inactivate	VBN
cord-017640-i8h48ny6	197	23	by	by	IN
cord-017640-i8h48ny6	197	24	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	197	25	[	[	-LRB-
cord-017640-i8h48ny6	197	26	135	135	CD
cord-017640-i8h48ny6	197	27	]	]	-RRB-
cord-017640-i8h48ny6	197	28	.	.	.
cord-017640-i8h48ny6	198	1	Overall	overall	RB
cord-017640-i8h48ny6	198	2	,	,	,
cord-017640-i8h48ny6	198	3	these	these	DT
cord-017640-i8h48ny6	198	4	findings	finding	NNS
cord-017640-i8h48ny6	198	5	suggest	suggest	VBP
cord-017640-i8h48ny6	198	6	that	that	IN
cord-017640-i8h48ny6	198	7	the	the	DT
cord-017640-i8h48ny6	198	8	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	198	9	machinery	machinery	NN
cord-017640-i8h48ny6	198	10	controls	control	VBZ
cord-017640-i8h48ny6	198	11	the	the	DT
cord-017640-i8h48ny6	198	12	necrotic	necrotic	JJ
cord-017640-i8h48ny6	198	13	one	one	CD
cord-017640-i8h48ny6	198	14	.	.	.
cord-017640-i8h48ny6	199	1	This	this	DT
cord-017640-i8h48ny6	199	2	concept	concept	NN
cord-017640-i8h48ny6	199	3	has	have	VBZ
cord-017640-i8h48ny6	199	4	been	be	VBN
cord-017640-i8h48ny6	199	5	recently	recently	RB
cord-017640-i8h48ny6	199	6	established	establish	VBN
cord-017640-i8h48ny6	199	7	in	in	IN
cord-017640-i8h48ny6	199	8	vivo	vivo	NN
cord-017640-i8h48ny6	199	9	by	by	IN
cord-017640-i8h48ny6	199	10	double	double	JJ
cord-017640-i8h48ny6	199	11	-	-	HYPH
cord-017640-i8h48ny6	199	12	KO	ko	NN
cord-017640-i8h48ny6	199	13	experiments	experiment	NNS
cord-017640-i8h48ny6	199	14	[	[	-LRB-
cord-017640-i8h48ny6	199	15	44	44	CD
cord-017640-i8h48ny6	199	16	]	]	-RRB-
cord-017640-i8h48ny6	199	17	[	[	-LRB-
cord-017640-i8h48ny6	199	18	45	45	CD
cord-017640-i8h48ny6	199	19	]	]	-RRB-
cord-017640-i8h48ny6	199	20	[	[	-LRB-
cord-017640-i8h48ny6	199	21	46	46	CD
cord-017640-i8h48ny6	199	22	]	]	-RRB-
cord-017640-i8h48ny6	199	23	136	136	CD
cord-017640-i8h48ny6	199	24	]	]	-RRB-
cord-017640-i8h48ny6	199	25	.	.	.
cord-017640-i8h48ny6	200	1	The	the	DT
cord-017640-i8h48ny6	200	2	KO	KO	NNP
cord-017640-i8h48ny6	200	3	of	of	IN
cord-017640-i8h48ny6	200	4	FADD	FADD	NNP
cord-017640-i8h48ny6	200	5	or	or	CC
cord-017640-i8h48ny6	200	6	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	200	7	is	be	VBZ
cord-017640-i8h48ny6	200	8	deleterious	deleterious	JJ
cord-017640-i8h48ny6	200	9	in	in	IN
cord-017640-i8h48ny6	200	10	mice	mouse	NNS
cord-017640-i8h48ny6	200	11	mainly	mainly	RB
cord-017640-i8h48ny6	200	12	by	by	IN
cord-017640-i8h48ny6	200	13	the	the	DT
cord-017640-i8h48ny6	200	14	fact	fact	NN
cord-017640-i8h48ny6	200	15	that	that	IN
cord-017640-i8h48ny6	200	16	these	these	DT
cord-017640-i8h48ny6	200	17	two	two	CD
cord-017640-i8h48ny6	200	18	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	200	19	factors	factor	NNS
cord-017640-i8h48ny6	200	20	are	be	VBP
cord-017640-i8h48ny6	200	21	beneficial	beneficial	JJ
cord-017640-i8h48ny6	200	22	in	in	IN
cord-017640-i8h48ny6	200	23	inhibiting	inhibit	VBG
cord-017640-i8h48ny6	200	24	a	a	DT
cord-017640-i8h48ny6	200	25	RIP1-/RIP3-dependent	rip1-/rip3-dependent	NN
cord-017640-i8h48ny6	200	26	necrotic	necrotic	JJ
cord-017640-i8h48ny6	200	27	signal	signal	NN
cord-017640-i8h48ny6	200	28	;	;	:
cord-017640-i8h48ny6	200	29	thus	thus	RB
cord-017640-i8h48ny6	200	30	,	,	,
cord-017640-i8h48ny6	200	31	their	-PRON-	PRP$
cord-017640-i8h48ny6	200	32	loss	loss	NN
cord-017640-i8h48ny6	200	33	unleashes	unleash	VBZ
cord-017640-i8h48ny6	200	34	the	the	DT
cord-017640-i8h48ny6	200	35	necroptotic	necroptotic	JJ
cord-017640-i8h48ny6	200	36	program	program	NN
cord-017640-i8h48ny6	200	37	and	and	CC
cord-017640-i8h48ny6	200	38	leads	lead	VBZ
cord-017640-i8h48ny6	200	39	to	to	IN
cord-017640-i8h48ny6	200	40	embryonic	embryonic	JJ
cord-017640-i8h48ny6	200	41	lethality	lethality	NN
cord-017640-i8h48ny6	200	42	.	.	.
cord-017640-i8h48ny6	201	1	Yet	yet	RB
cord-017640-i8h48ny6	201	2	,	,	,
cord-017640-i8h48ny6	201	3	most	most	JJS
cord-017640-i8h48ny6	201	4	studies	study	NNS
cord-017640-i8h48ny6	201	5	on	on	IN
cord-017640-i8h48ny6	201	6	necroptosis	necroptosis	NNP
cord-017640-i8h48ny6	201	7	have	have	VBP
cord-017640-i8h48ny6	201	8	focused	focus	VBN
cord-017640-i8h48ny6	201	9	on	on	IN
cord-017640-i8h48ny6	201	10	the	the	DT
cord-017640-i8h48ny6	201	11	TNF	TNF	NNP
cord-017640-i8h48ny6	201	12	signaling	signal	VBG
cord-017640-i8h48ny6	201	13	pathway	pathway	NN
cord-017640-i8h48ny6	201	14	,	,	,
cord-017640-i8h48ny6	201	15	whereas	whereas	IN
cord-017640-i8h48ny6	201	16	the	the	DT
cord-017640-i8h48ny6	201	17	mechanism	mechanism	NN
cord-017640-i8h48ny6	201	18	by	by	IN
cord-017640-i8h48ny6	201	19	which	which	WDT
cord-017640-i8h48ny6	201	20	CD95	CD95	NNP
cord-017640-i8h48ny6	201	21	can	can	MD
cord-017640-i8h48ny6	201	22	elicit	elicit	VB
cord-017640-i8h48ny6	201	23	this	this	DT
cord-017640-i8h48ny6	201	24	cell	cell	NN
cord-017640-i8h48ny6	201	25	death	death	NN
cord-017640-i8h48ny6	201	26	pathway	pathway	NN
cord-017640-i8h48ny6	201	27	,	,	,
cord-017640-i8h48ny6	201	28	and	and	CC
cord-017640-i8h48ny6	201	29	how	how	WRB
cord-017640-i8h48ny6	201	30	the	the	DT
cord-017640-i8h48ny6	201	31	switch	switch	NN
cord-017640-i8h48ny6	201	32	in	in	IN
cord-017640-i8h48ny6	201	33	this	this	DT
cord-017640-i8h48ny6	201	34	receptor	receptor	NN
cord-017640-i8h48ny6	201	35	occurs	occur	VBZ
cord-017640-i8h48ny6	201	36	between	between	IN
cord-017640-i8h48ny6	201	37	non	non	JJ
cord-017640-i8h48ny6	201	38	-	-	JJ
cord-017640-i8h48ny6	201	39	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	201	40	,	,	,
cord-017640-i8h48ny6	201	41	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	201	42	,	,	,
cord-017640-i8h48ny6	201	43	and	and	CC
cord-017640-i8h48ny6	201	44	necroptotic	necroptotic	JJ
cord-017640-i8h48ny6	201	45	signals	signal	NNS
cord-017640-i8h48ny6	201	46	remains	remain	VBZ
cord-017640-i8h48ny6	201	47	unclear	unclear	JJ
cord-017640-i8h48ny6	201	48	.	.	.
cord-017640-i8h48ny6	202	1	Importantly	importantly	RB
cord-017640-i8h48ny6	202	2	,	,	,
cord-017640-i8h48ny6	202	3	the	the	DT
cord-017640-i8h48ny6	202	4	impact	impact	NN
cord-017640-i8h48ny6	202	5	of	of	IN
cord-017640-i8h48ny6	202	6	each	each	DT
cord-017640-i8h48ny6	202	7	cell	cell	NN
cord-017640-i8h48ny6	202	8	death	death	NN
cord-017640-i8h48ny6	202	9	on	on	IN
cord-017640-i8h48ny6	202	10	antigen	antigen	NN
cord-017640-i8h48ny6	202	11	presentation	presentation	NN
cord-017640-i8h48ny6	202	12	,	,	,
cord-017640-i8h48ny6	202	13	and	and	CC
cord-017640-i8h48ny6	202	14	on	on	IN
cord-017640-i8h48ny6	202	15	the	the	DT
cord-017640-i8h48ny6	202	16	efficiency	efficiency	NN
cord-017640-i8h48ny6	202	17	of	of	IN
cord-017640-i8h48ny6	202	18	immune	immune	JJ
cord-017640-i8h48ny6	202	19	response	response	NN
cord-017640-i8h48ny6	202	20	after	after	IN
cord-017640-i8h48ny6	202	21	elimination	elimination	NN
cord-017640-i8h48ny6	202	22	of	of	IN
cord-017640-i8h48ny6	202	23	infected	infected	JJ
cord-017640-i8h48ny6	202	24	or	or	CC
cord-017640-i8h48ny6	202	25	transformed	transform	VBN
cord-017640-i8h48ny6	202	26	cells	cell	NNS
cord-017640-i8h48ny6	202	27	,	,	,
cord-017640-i8h48ny6	202	28	remains	remain	VBZ
cord-017640-i8h48ny6	202	29	unclear	unclear	JJ
cord-017640-i8h48ny6	202	30	.	.	.
cord-017640-i8h48ny6	203	1	Oncogenic	oncogenic	JJ
cord-017640-i8h48ny6	203	2	Cytokine	cytokine	NN
cord-017640-i8h48ny6	203	3	?	?	.
cord-017640-i8h48ny6	204	1	The	the	DT
cord-017640-i8h48ny6	204	2	transmembrane	transmembrane	NN
cord-017640-i8h48ny6	204	3	CD95L	cd95l	NN
cord-017640-i8h48ny6	205	1	(	(	-LRB-
cord-017640-i8h48ny6	205	2	CD178	CD178	NNP
cord-017640-i8h48ny6	205	3	/	/	SYM
cord-017640-i8h48ny6	205	4	FasL	FasL	NNP
cord-017640-i8h48ny6	205	5	)	)	-RRB-
cord-017640-i8h48ny6	205	6	is	be	VBZ
cord-017640-i8h48ny6	205	7	present	present	JJ
cord-017640-i8h48ny6	205	8	at	at	IN
cord-017640-i8h48ny6	205	9	the	the	DT
cord-017640-i8h48ny6	205	10	surface	surface	NN
cord-017640-i8h48ny6	205	11	of	of	IN
cord-017640-i8h48ny6	205	12	activated	activate	VBN
cord-017640-i8h48ny6	205	13	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	205	14	[	[	-LRB-
cord-017640-i8h48ny6	205	15	64	64	CD
cord-017640-i8h48ny6	205	16	]	]	-RRB-
cord-017640-i8h48ny6	205	17	and	and	CC
cord-017640-i8h48ny6	205	18	NK	NK	NNP
cord-017640-i8h48ny6	205	19	cells	cell	NNS
cord-017640-i8h48ny6	205	20	[	[	-LRB-
cord-017640-i8h48ny6	205	21	137	137	CD
cord-017640-i8h48ny6	205	22	]	]	-RRB-
cord-017640-i8h48ny6	206	1	where	where	WRB
cord-017640-i8h48ny6	206	2	it	-PRON-	PRP
cord-017640-i8h48ny6	206	3	orchestrates	orchestrate	VBZ
cord-017640-i8h48ny6	206	4	the	the	DT
cord-017640-i8h48ny6	206	5	elimination	elimination	NN
cord-017640-i8h48ny6	206	6	of	of	IN
cord-017640-i8h48ny6	206	7	transformed	transform	VBN
cord-017640-i8h48ny6	206	8	and	and	CC
cord-017640-i8h48ny6	206	9	infected	infected	JJ
cord-017640-i8h48ny6	206	10	cells	cell	NNS
cord-017640-i8h48ny6	206	11	.	.	.
cord-017640-i8h48ny6	207	1	In	in	IN
cord-017640-i8h48ny6	207	2	addition	addition	NN
cord-017640-i8h48ny6	207	3	,	,	,
cord-017640-i8h48ny6	207	4	CD95L	CD95L	NNP
cord-017640-i8h48ny6	207	5	is	be	VBZ
cord-017640-i8h48ny6	207	6	expressed	express	VBN
cord-017640-i8h48ny6	207	7	on	on	IN
cord-017640-i8h48ny6	207	8	the	the	DT
cord-017640-i8h48ny6	207	9	surface	surface	NN
cord-017640-i8h48ny6	207	10	of	of	IN
cord-017640-i8h48ny6	207	11	neurons	neuron	NNS
cord-017640-i8h48ny6	207	12	[	[	-LRB-
cord-017640-i8h48ny6	207	13	138	138	CD
cord-017640-i8h48ny6	207	14	]	]	-RRB-
cord-017640-i8h48ny6	207	15	,	,	,
cord-017640-i8h48ny6	207	16	corneal	corneal	JJ
cord-017640-i8h48ny6	207	17	epithelia	epithelium	NNS
cord-017640-i8h48ny6	207	18	and	and	CC
cord-017640-i8h48ny6	207	19	endothelia	endothelia	NNP
cord-017640-i8h48ny6	207	20	[	[	-LRB-
cord-017640-i8h48ny6	207	21	58	58	CD
cord-017640-i8h48ny6	207	22	,	,	,
cord-017640-i8h48ny6	207	23	139	139	CD
cord-017640-i8h48ny6	207	24	]	]	-RRB-
cord-017640-i8h48ny6	207	25	,	,	,
cord-017640-i8h48ny6	207	26	and	and	CC
cord-017640-i8h48ny6	207	27	Sertoli	Sertoli	NNP
cord-017640-i8h48ny6	207	28	cells	cell	NNS
cord-017640-i8h48ny6	207	29	[	[	-LRB-
cord-017640-i8h48ny6	207	30	59	59	CD
cord-017640-i8h48ny6	207	31	]	]	-RRB-
cord-017640-i8h48ny6	207	32	to	to	TO
cord-017640-i8h48ny6	207	33	prevent	prevent	VB
cord-017640-i8h48ny6	207	34	the	the	DT
cord-017640-i8h48ny6	207	35	infiltration	infiltration	NN
cord-017640-i8h48ny6	207	36	of	of	IN
cord-017640-i8h48ny6	207	37	immune	immune	JJ
cord-017640-i8h48ny6	207	38	cells	cell	NNS
cord-017640-i8h48ny6	207	39	and	and	CC
cord-017640-i8h48ny6	207	40	thus	thus	RB
cord-017640-i8h48ny6	207	41	to	to	TO
cord-017640-i8h48ny6	207	42	prohibit	prohibit	VB
cord-017640-i8h48ny6	207	43	the	the	DT
cord-017640-i8h48ny6	207	44	spread	spread	NN
cord-017640-i8h48ny6	207	45	of	of	IN
cord-017640-i8h48ny6	207	46	inflammation	inflammation	NN
cord-017640-i8h48ny6	207	47	in	in	IN
cord-017640-i8h48ny6	207	48	these	these	DT
cord-017640-i8h48ny6	207	49	sensitive	sensitive	JJ
cord-017640-i8h48ny6	207	50	organs	organ	NNS
cord-017640-i8h48ny6	207	51	(	(	-LRB-
cord-017640-i8h48ny6	207	52	i.e.	i.e.	FW
cord-017640-i8h48ny6	207	53	,	,	,
cord-017640-i8h48ny6	207	54	brain	brain	NN
cord-017640-i8h48ny6	207	55	,	,	,
cord-017640-i8h48ny6	207	56	eyes	eye	NNS
cord-017640-i8h48ny6	207	57	,	,	,
cord-017640-i8h48ny6	207	58	and	and	CC
cord-017640-i8h48ny6	207	59	testis	testis	NN
cord-017640-i8h48ny6	207	60	,	,	,
cord-017640-i8h48ny6	207	61	respectively	respectively	RB
cord-017640-i8h48ny6	207	62	)	)	-RRB-
cord-017640-i8h48ny6	207	63	,	,	,
cord-017640-i8h48ny6	207	64	commonly	commonly	RB
cord-017640-i8h48ny6	207	65	called	call	VBN
cord-017640-i8h48ny6	207	66	"	"	``
cord-017640-i8h48ny6	207	67	immune	immune	NN
cord-017640-i8h48ny6	207	68	-	-	HYPH
cord-017640-i8h48ny6	207	69	privileged	privileged	JJ
cord-017640-i8h48ny6	207	70	"	"	''
cord-017640-i8h48ny6	207	71	sites	site	NNS
cord-017640-i8h48ny6	207	72	.	.	.
cord-017640-i8h48ny6	208	1	The	the	DT
cord-017640-i8h48ny6	208	2	description	description	NN
cord-017640-i8h48ny6	208	3	of	of	IN
cord-017640-i8h48ny6	208	4	physiological	physiological	JJ
cord-017640-i8h48ny6	208	5	immune	immune	JJ
cord-017640-i8h48ny6	208	6	privilege	privilege	NN
cord-017640-i8h48ny6	208	7	was	be	VBD
cord-017640-i8h48ny6	208	8	followed	follow	VBN
cord-017640-i8h48ny6	208	9	by	by	IN
cord-017640-i8h48ny6	208	10	tumor	tumor	NN
cord-017640-i8h48ny6	208	11	-	-	HYPH
cord-017640-i8h48ny6	208	12	mediated	mediate	VBN
cord-017640-i8h48ny6	208	13	immune	immune	JJ
cord-017640-i8h48ny6	208	14	privilege	privilege	NN
cord-017640-i8h48ny6	208	15	,	,	,
cord-017640-i8h48ny6	208	16	since	since	IN
cord-017640-i8h48ny6	208	17	two	two	CD
cord-017640-i8h48ny6	208	18	groups	group	NNS
cord-017640-i8h48ny6	208	19	reported	report	VBD
cord-017640-i8h48ny6	208	20	that	that	IN
cord-017640-i8h48ny6	208	21	the	the	DT
cord-017640-i8h48ny6	208	22	ectopic	ectopic	JJ
cord-017640-i8h48ny6	208	23	expression	expression	NN
cord-017640-i8h48ny6	208	24	of	of	IN
cord-017640-i8h48ny6	208	25	CD95L	cd95l	NN
cord-017640-i8h48ny6	208	26	by	by	IN
cord-017640-i8h48ny6	208	27	malignant	malignant	JJ
cord-017640-i8h48ny6	208	28	cells	cell	NNS
cord-017640-i8h48ny6	208	29	participated	participate	VBN
cord-017640-i8h48ny6	208	30	in	in	IN
cord-017640-i8h48ny6	208	31	the	the	DT
cord-017640-i8h48ny6	208	32	elimination	elimination	NN
cord-017640-i8h48ny6	208	33	of	of	IN
cord-017640-i8h48ny6	208	34	infiltrating	infiltrate	VBG
cord-017640-i8h48ny6	208	35	T	t	NN
cord-017640-i8h48ny6	208	36	-	-	HYPH
cord-017640-i8h48ny6	208	37	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	208	38	and	and	CC
cord-017640-i8h48ny6	208	39	thus	thus	RB
cord-017640-i8h48ny6	208	40	could	could	MD
cord-017640-i8h48ny6	208	41	play	play	VB
cord-017640-i8h48ny6	208	42	a	a	DT
cord-017640-i8h48ny6	208	43	role	role	NN
cord-017640-i8h48ny6	208	44	in	in	IN
cord-017640-i8h48ny6	208	45	the	the	DT
cord-017640-i8h48ny6	208	46	establishment	establishment	NN
cord-017640-i8h48ny6	208	47	of	of	IN
cord-017640-i8h48ny6	208	48	a	a	DT
cord-017640-i8h48ny6	208	49	tumor	tumor	NN
cord-017640-i8h48ny6	208	50	site	site	NN
cord-017640-i8h48ny6	208	51	whose	whose	WP$
cord-017640-i8h48ny6	208	52	access	access	NN
cord-017640-i8h48ny6	208	53	was	be	VBD
cord-017640-i8h48ny6	208	54	denied	deny	VBN
cord-017640-i8h48ny6	208	55	to	to	IN
cord-017640-i8h48ny6	208	56	immune	immune	JJ
cord-017640-i8h48ny6	208	57	cells	cell	NNS
cord-017640-i8h48ny6	208	58	[	[	-LRB-
cord-017640-i8h48ny6	208	59	140	140	CD
cord-017640-i8h48ny6	208	60	,	,	,
cord-017640-i8h48ny6	208	61	141	141	CD
cord-017640-i8h48ny6	208	62	]	]	-RRB-
cord-017640-i8h48ny6	208	63	.	.	.
cord-017640-i8h48ny6	209	1	However	however	RB
cord-017640-i8h48ny6	209	2	,	,	,
cord-017640-i8h48ny6	209	3	these	these	DT
cord-017640-i8h48ny6	209	4	observations	observation	NNS
cord-017640-i8h48ny6	209	5	are	be	VBP
cord-017640-i8h48ny6	209	6	controversial	controversial	JJ
cord-017640-i8h48ny6	209	7	since	since	IN
cord-017640-i8h48ny6	209	8	ectopic	ectopic	JJ
cord-017640-i8h48ny6	209	9	expression	expression	NN
cord-017640-i8h48ny6	209	10	of	of	IN
cord-017640-i8h48ny6	209	11	CD95L	cd95l	NN
cord-017640-i8h48ny6	209	12	in	in	IN
cord-017640-i8h48ny6	209	13	allogenic	allogenic	JJ
cord-017640-i8h48ny6	209	14	transplant	transplant	NN
cord-017640-i8h48ny6	209	15	of	of	IN
cord-017640-i8h48ny6	209	16	β	β	NN
cord-017640-i8h48ny6	209	17	-	-	HYPH
cord-017640-i8h48ny6	209	18	islets	islet	NNS
cord-017640-i8h48ny6	209	19	[	[	-LRB-
cord-017640-i8h48ny6	209	20	142	142	CD
cord-017640-i8h48ny6	209	21	,	,	,
cord-017640-i8h48ny6	209	22	143	143	CD
cord-017640-i8h48ny6	209	23	]	]	-RRB-
cord-017640-i8h48ny6	209	24	and	and	CC
cord-017640-i8h48ny6	209	25	in	in	IN
cord-017640-i8h48ny6	209	26	tumor	tumor	NN
cord-017640-i8h48ny6	209	27	cell	cell	NN
cord-017640-i8h48ny6	209	28	lines	line	NNS
cord-017640-i8h48ny6	209	29	[	[	-LRB-
cord-017640-i8h48ny6	209	30	144	144	CD
cord-017640-i8h48ny6	209	31	]	]	-RRB-
cord-017640-i8h48ny6	209	32	led	lead	VBD
cord-017640-i8h48ny6	209	33	to	to	IN
cord-017640-i8h48ny6	209	34	a	a	DT
cord-017640-i8h48ny6	209	35	more	more	RBR
cord-017640-i8h48ny6	209	36	rapid	rapid	JJ
cord-017640-i8h48ny6	209	37	elimination	elimination	NN
cord-017640-i8h48ny6	209	38	of	of	IN
cord-017640-i8h48ny6	209	39	these	these	DT
cord-017640-i8h48ny6	209	40	cells	cell	NNS
cord-017640-i8h48ny6	209	41	than	than	IN
cord-017640-i8h48ny6	209	42	control	control	NN
cord-017640-i8h48ny6	209	43	cells	cell	NNS
cord-017640-i8h48ny6	209	44	,	,	,
cord-017640-i8h48ny6	209	45	due	due	JJ
cord-017640-i8h48ny6	209	46	to	to	IN
cord-017640-i8h48ny6	209	47	increased	increase	VBN
cord-017640-i8h48ny6	209	48	infiltration	infiltration	NN
cord-017640-i8h48ny6	209	49	of	of	IN
cord-017640-i8h48ny6	209	50	neutrophils	neutrophil	NNS
cord-017640-i8h48ny6	209	51	and	and	CC
cord-017640-i8h48ny6	209	52	macrophages	macrophage	NNS
cord-017640-i8h48ny6	209	53	endowed	endow	VBN
cord-017640-i8h48ny6	209	54	with	with	IN
cord-017640-i8h48ny6	209	55	antitumor	antitumor	JJ
cord-017640-i8h48ny6	209	56	activity	activity	NN
cord-017640-i8h48ny6	209	57	.	.	.
cord-017640-i8h48ny6	210	1	Among	among	IN
cord-017640-i8h48ny6	210	2	the	the	DT
cord-017640-i8h48ny6	210	3	weapons	weapon	NNS
cord-017640-i8h48ny6	210	4	at	at	IN
cord-017640-i8h48ny6	210	5	the	the	DT
cord-017640-i8h48ny6	210	6	disposal	disposal	NN
cord-017640-i8h48ny6	210	7	of	of	IN
cord-017640-i8h48ny6	210	8	immune	immune	JJ
cord-017640-i8h48ny6	210	9	cells	cell	NNS
cord-017640-i8h48ny6	210	10	,	,	,
cord-017640-i8h48ny6	210	11	transmembrane	transmembrane	NNP
cord-017640-i8h48ny6	210	12	CD95L	cd95l	NN
cord-017640-i8h48ny6	210	13	contributes	contribute	VBZ
cord-017640-i8h48ny6	210	14	to	to	IN
cord-017640-i8h48ny6	210	15	the	the	DT
cord-017640-i8h48ny6	210	16	elimination	elimination	NN
cord-017640-i8h48ny6	210	17	of	of	IN
cord-017640-i8h48ny6	210	18	pre	pre	JJ
cord-017640-i8h48ny6	210	19	-	-	JJ
cord-017640-i8h48ny6	210	20	tumor	tumor	JJ
cord-017640-i8h48ny6	210	21	cells	cell	NNS
cord-017640-i8h48ny6	210	22	.	.	.
cord-017640-i8h48ny6	211	1	Therefore	therefore	RB
cord-017640-i8h48ny6	211	2	,	,	,
cord-017640-i8h48ny6	211	3	pretumor	pretumor	NN
cord-017640-i8h48ny6	211	4	cells	cell	NNS
cord-017640-i8h48ny6	211	5	that	that	WDT
cord-017640-i8h48ny6	211	6	escape	escape	VBP
cord-017640-i8h48ny6	211	7	the	the	DT
cord-017640-i8h48ny6	211	8	immunosurveillance	immunosurveillance	NN
cord-017640-i8h48ny6	211	9	will	will	MD
cord-017640-i8h48ny6	211	10	be	be	VB
cord-017640-i8h48ny6	211	11	shaped	shape	VBN
cord-017640-i8h48ny6	211	12	to	to	TO
cord-017640-i8h48ny6	211	13	develop	develop	VB
cord-017640-i8h48ny6	211	14	resistance	resistance	NN
cord-017640-i8h48ny6	211	15	to	to	IN
cord-017640-i8h48ny6	211	16	CD95	CD95	NNP
cord-017640-i8h48ny6	211	17	,	,	,
cord-017640-i8h48ny6	211	18	a	a	DT
cord-017640-i8h48ny6	211	19	process	process	NN
cord-017640-i8h48ny6	211	20	termed	term	VBN
cord-017640-i8h48ny6	211	21	immunoediting	immunoedite	VBG
cord-017640-i8h48ny6	211	22	[	[	-LRB-
cord-017640-i8h48ny6	211	23	145	145	CD
cord-017640-i8h48ny6	211	24	]	]	-RRB-
cord-017640-i8h48ny6	211	25	.	.	.
cord-017640-i8h48ny6	212	1	In	in	IN
cord-017640-i8h48ny6	212	2	other	other	JJ
cord-017640-i8h48ny6	212	3	words	word	NNS
cord-017640-i8h48ny6	212	4	,	,	,
cord-017640-i8h48ny6	212	5	imprinting	imprinting	NN
cord-017640-i8h48ny6	212	6	of	of	IN
cord-017640-i8h48ny6	212	7	the	the	DT
cord-017640-i8h48ny6	212	8	immune	immune	JJ
cord-017640-i8h48ny6	212	9	system	system	NN
cord-017640-i8h48ny6	212	10	on	on	IN
cord-017640-i8h48ny6	212	11	pre	pre	JJ
cord-017640-i8h48ny6	212	12	-	-	JJ
cord-017640-i8h48ny6	212	13	tumor	tumor	JJ
cord-017640-i8h48ny6	212	14	cells	cell	NNS
cord-017640-i8h48ny6	212	15	will	will	MD
cord-017640-i8h48ny6	212	16	select	select	VB
cord-017640-i8h48ny6	212	17	malignant	malignant	JJ
cord-017640-i8h48ny6	212	18	cells	cell	NNS
cord-017640-i8h48ny6	212	19	with	with	IN
cord-017640-i8h48ny6	212	20	increased	increase	VBN
cord-017640-i8h48ny6	212	21	resistance	resistance	NN
cord-017640-i8h48ny6	212	22	toward	toward	IN
cord-017640-i8h48ny6	212	23	the	the	DT
cord-017640-i8h48ny6	212	24	CD95L	cd95l	NN
cord-017640-i8h48ny6	212	25	-	-	HYPH
cord-017640-i8h48ny6	212	26	induced	induce	VBN
cord-017640-i8h48ny6	212	27	signal	signal	NN
cord-017640-i8h48ny6	212	28	.	.	.
cord-017640-i8h48ny6	213	1	As	as	IN
cord-017640-i8h48ny6	213	2	previously	previously	RB
cord-017640-i8h48ny6	213	3	mentioned	mention	VBN
cord-017640-i8h48ny6	213	4	,	,	,
cord-017640-i8h48ny6	213	5	these	these	DT
cord-017640-i8h48ny6	213	6	alterations	alteration	NNS
cord-017640-i8h48ny6	213	7	of	of	IN
cord-017640-i8h48ny6	213	8	the	the	DT
cord-017640-i8h48ny6	213	9	CD95	CD95	NNP
cord-017640-i8h48ny6	213	10	signal	signal	NN
cord-017640-i8h48ny6	213	11	not	not	RB
cord-017640-i8h48ny6	213	12	only	only	RB
cord-017640-i8h48ny6	213	13	block	block	VB
cord-017640-i8h48ny6	213	14	the	the	DT
cord-017640-i8h48ny6	213	15	CD95mediated	cd95mediated	JJ
cord-017640-i8h48ny6	213	16	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	213	17	signal	signal	NN
cord-017640-i8h48ny6	213	18	but	but	CC
cord-017640-i8h48ny6	213	19	also	also	RB
cord-017640-i8h48ny6	213	20	promote	promote	VB
cord-017640-i8h48ny6	213	21	the	the	DT
cord-017640-i8h48ny6	213	22	transmission	transmission	NN
cord-017640-i8h48ny6	213	23	of	of	IN
cord-017640-i8h48ny6	213	24	non	non	JJ
cord-017640-i8h48ny6	213	25	-	-	JJ
cord-017640-i8h48ny6	213	26	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	213	27	signals	signal	NNS
cord-017640-i8h48ny6	213	28	by	by	IN
cord-017640-i8h48ny6	213	29	CD95L	CD95L	NNS
cord-017640-i8h48ny6	213	30	,	,	,
cord-017640-i8h48ny6	213	31	which	which	WDT
cord-017640-i8h48ny6	213	32	may	may	MD
cord-017640-i8h48ny6	213	33	play	play	VB
cord-017640-i8h48ny6	213	34	a	a	DT
cord-017640-i8h48ny6	213	35	critical	critical	JJ
cord-017640-i8h48ny6	213	36	role	role	NN
cord-017640-i8h48ny6	213	37	in	in	IN
cord-017640-i8h48ny6	213	38	carcinogenesis	carcinogenesis	NN
cord-017640-i8h48ny6	213	39	[	[	-LRB-
cord-017640-i8h48ny6	213	40	106	106	CD
cord-017640-i8h48ny6	213	41	]	]	-RRB-
cord-017640-i8h48ny6	213	42	[	[	-LRB-
cord-017640-i8h48ny6	213	43	107	107	CD
cord-017640-i8h48ny6	213	44	]	]	-RRB-
cord-017640-i8h48ny6	213	45	[	[	-LRB-
cord-017640-i8h48ny6	213	46	108	108	CD
cord-017640-i8h48ny6	213	47	]	]	-RRB-
cord-017640-i8h48ny6	213	48	146	146	CD
cord-017640-i8h48ny6	213	49	]	]	-RRB-
cord-017640-i8h48ny6	213	50	.	.	.
cord-017640-i8h48ny6	214	1	In	in	IN
cord-017640-i8h48ny6	214	2	agreement	agreement	NN
cord-017640-i8h48ny6	214	3	with	with	IN
cord-017640-i8h48ny6	214	4	this	this	DT
cord-017640-i8h48ny6	214	5	hypothesis	hypothesis	NN
cord-017640-i8h48ny6	214	6	,	,	,
cord-017640-i8h48ny6	214	7	a	a	DT
cord-017640-i8h48ny6	214	8	complete	complete	JJ
cord-017640-i8h48ny6	214	9	loss	loss	NN
cord-017640-i8h48ny6	214	10	of	of	IN
cord-017640-i8h48ny6	214	11	CD95	CD95	NNP
cord-017640-i8h48ny6	214	12	expression	expression	NN
cord-017640-i8h48ny6	214	13	is	be	VBZ
cord-017640-i8h48ny6	214	14	rarely	rarely	RB
cord-017640-i8h48ny6	214	15	observed	observe	VBN
cord-017640-i8h48ny6	214	16	in	in	IN
cord-017640-i8h48ny6	214	17	malignant	malignant	JJ
cord-017640-i8h48ny6	214	18	cells	cell	NNS
cord-017640-i8h48ny6	214	19	[	[	-LRB-
cord-017640-i8h48ny6	214	20	147	147	CD
cord-017640-i8h48ny6	214	21	]	]	-RRB-
cord-017640-i8h48ny6	214	22	.	.	.
cord-017640-i8h48ny6	215	1	Accumulating	accumulate	VBG
cord-017640-i8h48ny6	215	2	evidence	evidence	NN
cord-017640-i8h48ny6	215	3	indicates	indicate	VBZ
cord-017640-i8h48ny6	215	4	that	that	IN
cord-017640-i8h48ny6	215	5	the	the	DT
cord-017640-i8h48ny6	215	6	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	215	7	ligand	ligand	NN
cord-017640-i8h48ny6	215	8	CD95L	cd95l	NN
cord-017640-i8h48ny6	215	9	behaves	behave	VBZ
cord-017640-i8h48ny6	215	10	as	as	IN
cord-017640-i8h48ny6	215	11	a	a	DT
cord-017640-i8h48ny6	215	12	chemoattractant	chemoattractant	NN
cord-017640-i8h48ny6	215	13	for	for	IN
cord-017640-i8h48ny6	215	14	neutrophils	neutrophil	NNS
cord-017640-i8h48ny6	215	15	,	,	,
cord-017640-i8h48ny6	215	16	macrophages	macrophage	NNS
cord-017640-i8h48ny6	215	17	[	[	-LRB-
cord-017640-i8h48ny6	215	18	50	50	CD
cord-017640-i8h48ny6	215	19	,	,	,
cord-017640-i8h48ny6	215	20	143	143	CD
cord-017640-i8h48ny6	215	21	,	,	,
cord-017640-i8h48ny6	215	22	144	144	CD
cord-017640-i8h48ny6	215	23	]	]	-RRB-
cord-017640-i8h48ny6	215	24	,	,	,
cord-017640-i8h48ny6	215	25	T	t	NN
cord-017640-i8h48ny6	215	26	-	-	HYPH
cord-017640-i8h48ny6	215	27	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	215	28	[	[	-LRB-
cord-017640-i8h48ny6	215	29	53	53	CD
cord-017640-i8h48ny6	215	30	]	]	-RRB-
cord-017640-i8h48ny6	215	31	,	,	,
cord-017640-i8h48ny6	215	32	and	and	CC
cord-017640-i8h48ny6	215	33	malignant	malignant	JJ
cord-017640-i8h48ny6	215	34	cells	cell	NNS
cord-017640-i8h48ny6	215	35	in	in	IN
cord-017640-i8h48ny6	215	36	which	which	WDT
cord-017640-i8h48ny6	215	37	the	the	DT
cord-017640-i8h48ny6	215	38	CD95-mediated	cd95-mediated	CD
cord-017640-i8h48ny6	215	39	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	215	40	signal	signal	NN
cord-017640-i8h48ny6	215	41	is	be	VBZ
cord-017640-i8h48ny6	215	42	nonproductive	nonproductive	JJ
cord-017640-i8h48ny6	215	43	[	[	-LRB-
cord-017640-i8h48ny6	215	44	108	108	CD
cord-017640-i8h48ny6	215	45	,	,	,
cord-017640-i8h48ny6	215	46	148	148	CD
cord-017640-i8h48ny6	215	47	]	]	-RRB-
cord-017640-i8h48ny6	215	48	.	.	.
cord-017640-i8h48ny6	216	1	Nonetheless	nonetheless	RB
cord-017640-i8h48ny6	216	2	,	,	,
cord-017640-i8h48ny6	216	3	the	the	DT
cord-017640-i8h48ny6	216	4	biological	biological	JJ
cord-017640-i8h48ny6	216	5	role	role	NN
cord-017640-i8h48ny6	216	6	of	of	IN
cord-017640-i8h48ny6	216	7	CD95L	CD95L	NNP
cord-017640-i8h48ny6	216	8	has	have	VBZ
cord-017640-i8h48ny6	216	9	to	to	TO
cord-017640-i8h48ny6	216	10	be	be	VB
cord-017640-i8h48ny6	216	11	clarified	clarify	VBN
cord-017640-i8h48ny6	216	12	due	due	IN
cord-017640-i8h48ny6	216	13	to	to	IN
cord-017640-i8h48ny6	216	14	the	the	DT
cord-017640-i8h48ny6	216	15	fact	fact	NN
cord-017640-i8h48ny6	216	16	that	that	IN
cord-017640-i8h48ny6	216	17	pathophysiologically	pathophysiologically	RB
cord-017640-i8h48ny6	216	18	the	the	DT
cord-017640-i8h48ny6	216	19	ligand	ligand	NN
cord-017640-i8h48ny6	216	20	is	be	VBZ
cord-017640-i8h48ny6	216	21	present	present	JJ
cord-017640-i8h48ny6	216	22	in	in	IN
cord-017640-i8h48ny6	216	23	at	at	RB
cord-017640-i8h48ny6	216	24	least	least	RBS
cord-017640-i8h48ny6	216	25	two	two	CD
cord-017640-i8h48ny6	216	26	forms	form	NNS
cord-017640-i8h48ny6	216	27	with	with	IN
cord-017640-i8h48ny6	216	28	different	different	JJ
cord-017640-i8h48ny6	216	29	stoichiometries	stoichiometry	NNS
cord-017640-i8h48ny6	216	30	.	.	.
cord-017640-i8h48ny6	217	1	Indeed	indeed	RB
cord-017640-i8h48ny6	217	2	,	,	,
cord-017640-i8h48ny6	217	3	CD95L	CD95L	NNP
cord-017640-i8h48ny6	217	4	is	be	VBZ
cord-017640-i8h48ny6	217	5	a	a	DT
cord-017640-i8h48ny6	217	6	transmembrane	transmembrane	JJ
cord-017640-i8h48ny6	217	7	cytokine	cytokine	NN
cord-017640-i8h48ny6	217	8	whose	whose	WP$
cord-017640-i8h48ny6	217	9	ectodomain	ectodomain	NN
cord-017640-i8h48ny6	217	10	can	can	MD
cord-017640-i8h48ny6	217	11	be	be	VB
cord-017640-i8h48ny6	217	12	cleaved	cleave	VBN
cord-017640-i8h48ny6	217	13	by	by	IN
cord-017640-i8h48ny6	217	14	metalloproteases	metalloprotease	NNS
cord-017640-i8h48ny6	217	15	such	such	JJ
cord-017640-i8h48ny6	217	16	as	as	IN
cord-017640-i8h48ny6	217	17	MMP3	MMP3	NNP
cord-017640-i8h48ny6	217	18	[	[	-LRB-
cord-017640-i8h48ny6	217	19	149	149	CD
cord-017640-i8h48ny6	217	20	]	]	-RRB-
cord-017640-i8h48ny6	217	21	,	,	,
cord-017640-i8h48ny6	217	22	MMP7	MMP7	NNP
cord-017640-i8h48ny6	217	23	[	[	-LRB-
cord-017640-i8h48ny6	217	24	150	150	CD
cord-017640-i8h48ny6	217	25	]	]	-RRB-
cord-017640-i8h48ny6	217	26	,	,	,
cord-017640-i8h48ny6	217	27	MMP9	MMP9	NNP
cord-017640-i8h48ny6	217	28	[	[	-LRB-
cord-017640-i8h48ny6	217	29	151	151	CD
cord-017640-i8h48ny6	217	30	]	]	-RRB-
cord-017640-i8h48ny6	217	31	,	,	,
cord-017640-i8h48ny6	217	32	and	and	CC
cord-017640-i8h48ny6	217	33	ADAM-10	adam-10	CD
cord-017640-i8h48ny6	217	34	(	(	-LRB-
cord-017640-i8h48ny6	217	35	a	a	DT
cord-017640-i8h48ny6	217	36	disintegrin	disintegrin	NN
cord-017640-i8h48ny6	217	37	and	and	CC
cord-017640-i8h48ny6	217	38	metalloproteinase	metalloproteinase	NN
cord-017640-i8h48ny6	217	39	10	10	CD
cord-017640-i8h48ny6	217	40	)	)	-RRB-
cord-017640-i8h48ny6	217	41	[	[	-LRB-
cord-017640-i8h48ny6	217	42	152	152	CD
cord-017640-i8h48ny6	217	43	,	,	,
cord-017640-i8h48ny6	217	44	153	153	CD
cord-017640-i8h48ny6	217	45	]	]	-RRB-
cord-017640-i8h48ny6	217	46	and	and	CC
cord-017640-i8h48ny6	217	47	released	release	VBD
cord-017640-i8h48ny6	217	48	as	as	IN
cord-017640-i8h48ny6	217	49	a	a	DT
cord-017640-i8h48ny6	217	50	soluble	soluble	JJ
cord-017640-i8h48ny6	217	51	ligand	ligand	NN
cord-017640-i8h48ny6	217	52	in	in	IN
cord-017640-i8h48ny6	217	53	the	the	DT
cord-017640-i8h48ny6	217	54	bloodstream	bloodstream	NN
cord-017640-i8h48ny6	217	55	.	.	.
cord-017640-i8h48ny6	218	1	Based	base	VBN
cord-017640-i8h48ny6	218	2	on	on	IN
cord-017640-i8h48ny6	218	3	the	the	DT
cord-017640-i8h48ny6	218	4	data	datum	NNS
cord-017640-i8h48ny6	218	5	demonstrating	demonstrate	VBG
cord-017640-i8h48ny6	218	6	that	that	IN
cord-017640-i8h48ny6	218	7	a	a	DT
cord-017640-i8h48ny6	218	8	hexameric	hexameric	NN
cord-017640-i8h48ny6	218	9	CD95L	cd95l	NN
cord-017640-i8h48ny6	218	10	represents	represent	VBZ
cord-017640-i8h48ny6	218	11	the	the	DT
cord-017640-i8h48ny6	218	12	minimal	minimal	JJ
cord-017640-i8h48ny6	218	13	level	level	NN
cord-017640-i8h48ny6	218	14	of	of	IN
cord-017640-i8h48ny6	218	15	selfassociation	selfassociation	NN
cord-017640-i8h48ny6	218	16	required	require	VBN
cord-017640-i8h48ny6	218	17	to	to	TO
cord-017640-i8h48ny6	218	18	signal	signal	VB
cord-017640-i8h48ny6	218	19	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	218	20	[	[	-LRB-
cord-017640-i8h48ny6	218	21	154	154	CD
cord-017640-i8h48ny6	218	22	]	]	-RRB-
cord-017640-i8h48ny6	218	23	and	and	CC
cord-017640-i8h48ny6	218	24	that	that	DT
cord-017640-i8h48ny6	218	25	cleavage	cleavage	NN
cord-017640-i8h48ny6	218	26	by	by	IN
cord-017640-i8h48ny6	218	27	metalloproteases	metalloproteases	NNP
cord-017640-i8h48ny6	218	28	releases	release	VBZ
cord-017640-i8h48ny6	218	29	an	an	DT
cord-017640-i8h48ny6	218	30	homotrimeric	homotrimeric	JJ
cord-017640-i8h48ny6	218	31	ligand	ligand	NN
cord-017640-i8h48ny6	218	32	[	[	-LRB-
cord-017640-i8h48ny6	218	33	154	154	CD
cord-017640-i8h48ny6	218	34	,	,	,
cord-017640-i8h48ny6	218	35	155	155	CD
cord-017640-i8h48ny6	218	36	]	]	-RRB-
cord-017640-i8h48ny6	218	37	,	,	,
cord-017640-i8h48ny6	218	38	this	this	DT
cord-017640-i8h48ny6	218	39	soluble	soluble	JJ
cord-017640-i8h48ny6	218	40	ligand	ligand	NN
cord-017640-i8h48ny6	218	41	has	have	VBZ
cord-017640-i8h48ny6	218	42	long	long	RB
cord-017640-i8h48ny6	218	43	been	be	VBN
cord-017640-i8h48ny6	218	44	considered	consider	VBN
cord-017640-i8h48ny6	218	45	as	as	IN
cord-017640-i8h48ny6	218	46	an	an	DT
cord-017640-i8h48ny6	218	47	inert	inert	JJ
cord-017640-i8h48ny6	218	48	ligand	ligand	NN
cord-017640-i8h48ny6	218	49	competing	compete	VBG
cord-017640-i8h48ny6	218	50	with	with	IN
cord-017640-i8h48ny6	218	51	its	-PRON-	PRP$
cord-017640-i8h48ny6	218	52	membrane	membrane	NN
cord-017640-i8h48ny6	218	53	-	-	HYPH
cord-017640-i8h48ny6	218	54	bound	bind	VBN
cord-017640-i8h48ny6	218	55	counterpart	counterpart	NN
cord-017640-i8h48ny6	218	56	for	for	IN
cord-017640-i8h48ny6	218	57	CD95	CD95	NNP
cord-017640-i8h48ny6	218	58	binding	binding	NN
cord-017640-i8h48ny6	218	59	,	,	,
cord-017640-i8h48ny6	218	60	thus	thus	RB
cord-017640-i8h48ny6	218	61	acting	act	VBG
cord-017640-i8h48ny6	218	62	as	as	IN
cord-017640-i8h48ny6	218	63	an	an	DT
cord-017640-i8h48ny6	218	64	antagonist	antagonist	NN
cord-017640-i8h48ny6	218	65	of	of	IN
cord-017640-i8h48ny6	218	66	the	the	DT
cord-017640-i8h48ny6	218	67	death	death	NN
cord-017640-i8h48ny6	218	68	signal	signal	NN
cord-017640-i8h48ny6	218	69	[	[	-LRB-
cord-017640-i8h48ny6	218	70	155	155	CD
cord-017640-i8h48ny6	218	71	,	,	,
cord-017640-i8h48ny6	218	72	156	156	CD
cord-017640-i8h48ny6	218	73	]	]	-RRB-
cord-017640-i8h48ny6	218	74	.	.	.
cord-017640-i8h48ny6	219	1	It	-PRON-	PRP
cord-017640-i8h48ny6	219	2	has	have	VBZ
cord-017640-i8h48ny6	219	3	been	be	VBN
cord-017640-i8h48ny6	219	4	recently	recently	RB
cord-017640-i8h48ny6	219	5	demonstrated	demonstrate	VBN
cord-017640-i8h48ny6	219	6	that	that	IN
cord-017640-i8h48ny6	219	7	this	this	DT
cord-017640-i8h48ny6	219	8	metalloprotease	metalloprotease	NN
cord-017640-i8h48ny6	219	9	-	-	HYPH
cord-017640-i8h48ny6	219	10	cleaved	cleave	VBN
cord-017640-i8h48ny6	219	11	CD95L	cd95l	NN
cord-017640-i8h48ny6	219	12	(	(	-LRB-
cord-017640-i8h48ny6	219	13	cl	cl	NNP
cord-017640-i8h48ny6	219	14	-	-	HYPH
cord-017640-i8h48ny6	219	15	CD95L	CD95L	NNP
cord-017640-i8h48ny6	219	16	)	)	-RRB-
cord-017640-i8h48ny6	219	17	actively	actively	RB
cord-017640-i8h48ny6	219	18	participates	participate	VBZ
cord-017640-i8h48ny6	219	19	in	in	IN
cord-017640-i8h48ny6	219	20	the	the	DT
cord-017640-i8h48ny6	219	21	aggravation	aggravation	NN
cord-017640-i8h48ny6	219	22	of	of	IN
cord-017640-i8h48ny6	219	23	inflammation	inflammation	NN
cord-017640-i8h48ny6	219	24	and	and	CC
cord-017640-i8h48ny6	219	25	autoimmunity	autoimmunity	NN
cord-017640-i8h48ny6	219	26	in	in	IN
cord-017640-i8h48ny6	219	27	patients	patient	NNS
cord-017640-i8h48ny6	219	28	affected	affect	VBN
cord-017640-i8h48ny6	219	29	by	by	IN
cord-017640-i8h48ny6	219	30	systemic	systemic	JJ
cord-017640-i8h48ny6	219	31	lupus	lupus	NN
cord-017640-i8h48ny6	219	32	erythematosus	erythematosus	NN
cord-017640-i8h48ny6	219	33	(	(	-LRB-
cord-017640-i8h48ny6	219	34	SLE	SLE	NNP
cord-017640-i8h48ny6	219	35	)	)	-RRB-
cord-017640-i8h48ny6	219	36	by	by	IN
cord-017640-i8h48ny6	219	37	inducing	induce	VBG
cord-017640-i8h48ny6	219	38	the	the	DT
cord-017640-i8h48ny6	219	39	non	non	JJ
cord-017640-i8h48ny6	219	40	-	-	JJ
cord-017640-i8h48ny6	219	41	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	219	42	NF	nf	NN
cord-017640-i8h48ny6	219	43	-	-	HYPH
cord-017640-i8h48ny6	219	44	κB	κB	NNP
cord-017640-i8h48ny6	219	45	and	and	CC
cord-017640-i8h48ny6	219	46	PI3	PI3	NNP
cord-017640-i8h48ny6	219	47	K	K	NNP
cord-017640-i8h48ny6	219	48	[	[	-LRB-
cord-017640-i8h48ny6	219	49	51	51	CD
cord-017640-i8h48ny6	219	50	,	,	,
cord-017640-i8h48ny6	219	51	53	53	CD
cord-017640-i8h48ny6	219	52	]	]	-RRB-
cord-017640-i8h48ny6	219	53	signaling	signal	VBG
cord-017640-i8h48ny6	219	54	pathways	pathway	NNS
cord-017640-i8h48ny6	219	55	(	(	-LRB-
cord-017640-i8h48ny6	219	56	Fig	Fig	NNP
cord-017640-i8h48ny6	219	57	.	.	.
cord-017640-i8h48ny6	219	58	11.4	11.4	CD
cord-017640-i8h48ny6	219	59	)	)	-RRB-
cord-017640-i8h48ny6	219	60	.	.	.
cord-017640-i8h48ny6	220	1	Unlike	unlike	IN
cord-017640-i8h48ny6	220	2	transmembrane	transmembrane	NNP
cord-017640-i8h48ny6	220	3	CD95L	cd95l	NN
cord-017640-i8h48ny6	220	4	,	,	,
cord-017640-i8h48ny6	220	5	induction	induction	NN
cord-017640-i8h48ny6	220	6	of	of	IN
cord-017640-i8h48ny6	220	7	the	the	DT
cord-017640-i8h48ny6	220	8	PI3	PI3	NNP
cord-017640-i8h48ny6	220	9	K	K	NNP
cord-017640-i8h48ny6	220	10	signaling	signal	VBG
cord-017640-i8h48ny6	220	11	pathway	pathway	NN
cord-017640-i8h48ny6	220	12	by	by	IN
cord-017640-i8h48ny6	220	13	its	-PRON-	PRP$
cord-017640-i8h48ny6	220	14	metalloproteasecleaved	metalloproteasecleaved	JJ
cord-017640-i8h48ny6	220	15	counterpart	counterpart	NN
cord-017640-i8h48ny6	220	16	occurs	occur	VBZ
cord-017640-i8h48ny6	220	17	through	through	IN
cord-017640-i8h48ny6	220	18	the	the	DT
cord-017640-i8h48ny6	220	19	formation	formation	NN
cord-017640-i8h48ny6	220	20	of	of	IN
cord-017640-i8h48ny6	220	21	a	a	DT
cord-017640-i8h48ny6	220	22	complex	complex	JJ
cord-017640-i8h48ny6	220	23	devoid	devoid	NN
cord-017640-i8h48ny6	220	24	of	of	IN
cord-017640-i8h48ny6	220	25	FADD	FADD	NNP
cord-017640-i8h48ny6	220	26	and	and	CC
cord-017640-i8h48ny6	220	27	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	220	28	which	which	WDT
cord-017640-i8h48ny6	220	29	recruits	recruit	VBZ
cord-017640-i8h48ny6	220	30	the	the	DT
cord-017640-i8h48ny6	220	31	src	src	NNP
cord-017640-i8h48ny6	220	32	kinase	kinase	NNP
cord-017640-i8h48ny6	220	33	c	c	NNP
cord-017640-i8h48ny6	221	1	-yes	-yes	:
cord-017640-i8h48ny6	221	2	instead	instead	RB
cord-017640-i8h48ny6	221	3	[	[	-LRB-
cord-017640-i8h48ny6	221	4	53	53	CD
cord-017640-i8h48ny6	221	5	,	,	,
cord-017640-i8h48ny6	221	6	148	148	CD
cord-017640-i8h48ny6	221	7	]	]	-RRB-
cord-017640-i8h48ny6	221	8	;	;	:
cord-017640-i8h48ny6	221	9	this	this	DT
cord-017640-i8h48ny6	221	10	unconventional	unconventional	JJ
cord-017640-i8h48ny6	221	11	receptosome	receptosome	NNP
cord-017640-i8h48ny6	221	12	was	be	VBD
cord-017640-i8h48ny6	221	13	designated	designate	VBN
cord-017640-i8h48ny6	221	14	motility	motility	NN
cord-017640-i8h48ny6	221	15	-	-	HYPH
cord-017640-i8h48ny6	221	16	inducing	induce	VBG
cord-017640-i8h48ny6	221	17	signaling	signal	VBG
cord-017640-i8h48ny6	221	18	complex	complex	NN
cord-017640-i8h48ny6	221	19	(	(	-LRB-
cord-017640-i8h48ny6	221	20	MISC	MISC	NNP
cord-017640-i8h48ny6	221	21	)	)	-RRB-
cord-017640-i8h48ny6	221	22	[	[	-LRB-
cord-017640-i8h48ny6	221	23	53	53	CD
cord-017640-i8h48ny6	221	24	,	,	,
cord-017640-i8h48ny6	221	25	157	157	CD
cord-017640-i8h48ny6	221	26	]	]	-RRB-
cord-017640-i8h48ny6	222	1	(	(	-LRB-
cord-017640-i8h48ny6	222	2	Fig	Fig	NNP
cord-017640-i8h48ny6	222	3	.	.	.
cord-017640-i8h48ny6	222	4	11.4	11.4	CD
cord-017640-i8h48ny6	222	5	)	)	-RRB-
cord-017640-i8h48ny6	222	6	.	.	.
cord-017640-i8h48ny6	223	1	Even	even	RB
cord-017640-i8h48ny6	223	2	though	though	IN
cord-017640-i8h48ny6	223	3	experiments	experiment	NNS
cord-017640-i8h48ny6	223	4	by	by	IN
cord-017640-i8h48ny6	223	5	the	the	DT
cord-017640-i8h48ny6	223	6	authors	author	NNS
cord-017640-i8h48ny6	223	7	did	do	VBD
cord-017640-i8h48ny6	223	8	not	not	RB
cord-017640-i8h48ny6	223	9	detect	detect	VB
cord-017640-i8h48ny6	223	10	any	any	DT
cord-017640-i8h48ny6	223	11	trace	trace	NN
cord-017640-i8h48ny6	223	12	of	of	IN
cord-017640-i8h48ny6	223	13	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	223	14	in	in	IN
cord-017640-i8h48ny6	223	15	the	the	DT
cord-017640-i8h48ny6	223	16	MISC	MISC	NNS
cord-017640-i8h48ny6	223	17	,	,	,
cord-017640-i8h48ny6	223	18	this	this	DT
cord-017640-i8h48ny6	223	19	enzyme	enzyme	NN
cord-017640-i8h48ny6	223	20	has	have	VBZ
cord-017640-i8h48ny6	223	21	been	be	VBN
cord-017640-i8h48ny6	223	22	shown	show	VBN
cord-017640-i8h48ny6	223	23	to	to	TO
cord-017640-i8h48ny6	223	24	participate	participate	VB
cord-017640-i8h48ny6	223	25	in	in	IN
cord-017640-i8h48ny6	223	26	cell	cell	NN
cord-017640-i8h48ny6	223	27	migration	migration	NN
cord-017640-i8h48ny6	223	28	.	.	.
cord-017640-i8h48ny6	224	1	The	the	DT
cord-017640-i8h48ny6	224	2	protease	protease	NN
cord-017640-i8h48ny6	224	3	activity	activity	NN
cord-017640-i8h48ny6	224	4	of	of	IN
cord-017640-i8h48ny6	224	5	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	224	6	can	can	MD
cord-017640-i8h48ny6	224	7	be	be	VB
cord-017640-i8h48ny6	224	8	abolished	abolish	VBN
cord-017640-i8h48ny6	224	9	by	by	IN
cord-017640-i8h48ny6	224	10	its	-PRON-	PRP$
cord-017640-i8h48ny6	224	11	phosphorylation	phosphorylation	NN
cord-017640-i8h48ny6	224	12	at	at	IN
cord-017640-i8h48ny6	224	13	tyrosine	tyrosine	NN
cord-017640-i8h48ny6	224	14	380	380	CD
cord-017640-i8h48ny6	224	15	by	by	IN
cord-017640-i8h48ny6	224	16	src	src	NNP
cord-017640-i8h48ny6	224	17	kinase	kinase	NNP
cord-017640-i8h48ny6	224	18	[	[	-LRB-
cord-017640-i8h48ny6	224	19	158	158	CD
cord-017640-i8h48ny6	224	20	]	]	-RRB-
cord-017640-i8h48ny6	224	21	.	.	.
cord-017640-i8h48ny6	225	1	This	this	DT
cord-017640-i8h48ny6	225	2	posttranslational	posttranslational	JJ
cord-017640-i8h48ny6	225	3	modification	modification	NN
cord-017640-i8h48ny6	225	4	was	be	VBD
cord-017640-i8h48ny6	225	5	observed	observe	VBN
cord-017640-i8h48ny6	225	6	in	in	IN
cord-017640-i8h48ny6	225	7	cells	cell	NNS
cord-017640-i8h48ny6	225	8	stimulated	stimulate	VBN
cord-017640-i8h48ny6	225	9	with	with	IN
cord-017640-i8h48ny6	225	10	EGF	EGF	NNP
cord-017640-i8h48ny6	225	11	and	and	CC
cord-017640-i8h48ny6	225	12	in	in	IN
cord-017640-i8h48ny6	225	13	colon	colon	NN
cord-017640-i8h48ny6	225	14	cancer	cancer	NN
cord-017640-i8h48ny6	225	15	cells	cell	NNS
cord-017640-i8h48ny6	225	16	exhibiting	exhibit	VBG
cord-017640-i8h48ny6	225	17	constitutive	constitutive	JJ
cord-017640-i8h48ny6	225	18	activation	activation	NN
cord-017640-i8h48ny6	225	19	of	of	IN
cord-017640-i8h48ny6	225	20	src	src	NNP
cord-017640-i8h48ny6	225	21	;	;	:
cord-017640-i8h48ny6	225	22	from	from	IN
cord-017640-i8h48ny6	225	23	a	a	DT
cord-017640-i8h48ny6	225	24	molecular	molecular	JJ
cord-017640-i8h48ny6	225	25	standpoint	standpoint	NN
cord-017640-i8h48ny6	225	26	,	,	,
cord-017640-i8h48ny6	225	27	this	this	DT
cord-017640-i8h48ny6	225	28	modification	modification	NN
cord-017640-i8h48ny6	225	29	does	do	VBZ
cord-017640-i8h48ny6	225	30	not	not	RB
cord-017640-i8h48ny6	225	31	alter	alter	VB
cord-017640-i8h48ny6	225	32	caspase	caspase	NN
cord-017640-i8h48ny6	225	33	homodimerization	homodimerization	NN
cord-017640-i8h48ny6	225	34	or	or	CC
cord-017640-i8h48ny6	225	35	recruitment	recruitment	NN
cord-017640-i8h48ny6	225	36	in	in	IN
cord-017640-i8h48ny6	225	37	DISC	DISC	NNP
cord-017640-i8h48ny6	225	38	[	[	-LRB-
cord-017640-i8h48ny6	225	39	158	158	CD
cord-017640-i8h48ny6	225	40	]	]	-RRB-
cord-017640-i8h48ny6	225	41	.	.	.
cord-017640-i8h48ny6	226	1	Moreover	moreover	RB
cord-017640-i8h48ny6	226	2	,	,	,
cord-017640-i8h48ny6	226	3	the	the	DT
cord-017640-i8h48ny6	226	4	EGFR	egfr	NN
cord-017640-i8h48ny6	226	5	-	-	HYPH
cord-017640-i8h48ny6	226	6	driven	drive	VBN
cord-017640-i8h48ny6	226	7	phosphorylation	phosphorylation	NN
cord-017640-i8h48ny6	226	8	of	of	IN
cord-017640-i8h48ny6	226	9	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	226	10	at	at	IN
cord-017640-i8h48ny6	226	11	Y380	Y380	NNP
cord-017640-i8h48ny6	226	12	turns	turn	NNS
cord-017640-i8h48ny6	226	13	out	out	RP
cord-017640-i8h48ny6	226	14	to	to	TO
cord-017640-i8h48ny6	226	15	be	be	VB
cord-017640-i8h48ny6	226	16	a	a	DT
cord-017640-i8h48ny6	226	17	potent	potent	JJ
cord-017640-i8h48ny6	226	18	inducer	inducer	NN
cord-017640-i8h48ny6	226	19	of	of	IN
cord-017640-i8h48ny6	226	20	the	the	DT
cord-017640-i8h48ny6	226	21	PI3	PI3	NNP
cord-017640-i8h48ny6	226	22	K	K	NNP
cord-017640-i8h48ny6	226	23	signaling	signal	VBG
cord-017640-i8h48ny6	226	24	pathway	pathway	NN
cord-017640-i8h48ny6	226	25	by	by	IN
cord-017640-i8h48ny6	226	26	recruiting	recruit	VBG
cord-017640-i8h48ny6	226	27	the	the	DT
cord-017640-i8h48ny6	226	28	PI3	pi3	NN
cord-017640-i8h48ny6	226	29	K	K	NNP
cord-017640-i8h48ny6	226	30	adaptor	adaptor	NN
cord-017640-i8h48ny6	226	31	p85	p85	NN
cord-017640-i8h48ny6	226	32	alpha	alpha	NN
cord-017640-i8h48ny6	226	33	subunit	subunit	NN
cord-017640-i8h48ny6	226	34	[	[	-LRB-
cord-017640-i8h48ny6	226	35	159	159	CD
cord-017640-i8h48ny6	226	36	]	]	-RRB-
cord-017640-i8h48ny6	226	37	.	.	.
cord-017640-i8h48ny6	227	1	Ultimately	ultimately	RB
cord-017640-i8h48ny6	227	2	,	,	,
cord-017640-i8h48ny6	227	3	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	227	4	phosphorylation	phosphorylation	NN
cord-017640-i8h48ny6	227	5	triggers	trigger	VBZ
cord-017640-i8h48ny6	227	6	cell	cell	NN
cord-017640-i8h48ny6	227	7	migration	migration	NN
cord-017640-i8h48ny6	227	8	.	.	.
cord-017640-i8h48ny6	228	1	Nonetheless	nonetheless	RB
cord-017640-i8h48ny6	228	2	,	,	,
cord-017640-i8h48ny6	228	3	it	-PRON-	PRP
cord-017640-i8h48ny6	228	4	is	be	VBZ
cord-017640-i8h48ny6	228	5	noteworthy	noteworthy	JJ
cord-017640-i8h48ny6	228	6	that	that	IN
cord-017640-i8h48ny6	228	7	CD95-induced	cd95-induced	CD
cord-017640-i8h48ny6	228	8	migration	migration	NN
cord-017640-i8h48ny6	228	9	and	and	CC
cord-017640-i8h48ny6	228	10	invasion	invasion	NN
cord-017640-i8h48ny6	228	11	do	do	VBP
cord-017640-i8h48ny6	228	12	not	not	RB
cord-017640-i8h48ny6	228	13	appear	appear	VB
cord-017640-i8h48ny6	228	14	to	to	TO
cord-017640-i8h48ny6	228	15	require	require	VB
cord-017640-i8h48ny6	228	16	an	an	DT
cord-017640-i8h48ny6	228	17	intact	intact	JJ
cord-017640-i8h48ny6	228	18	DD	dd	NN
cord-017640-i8h48ny6	228	19	(	(	-LRB-
cord-017640-i8h48ny6	228	20	reviewed	review	VBN
cord-017640-i8h48ny6	228	21	in	in	IN
cord-017640-i8h48ny6	228	22	[	[	-LRB-
cord-017640-i8h48ny6	228	23	160	160	CD
cord-017640-i8h48ny6	228	24	]	]	-RRB-
cord-017640-i8h48ny6	228	25	)	)	-RRB-
cord-017640-i8h48ny6	228	26	,	,	,
cord-017640-i8h48ny6	228	27	suggesting	suggest	VBG
cord-017640-i8h48ny6	228	28	that	that	IN
cord-017640-i8h48ny6	228	29	either	either	CC
cord-017640-i8h48ny6	228	30	the	the	DT
cord-017640-i8h48ny6	228	31	caspase-8-dependent	caspase-8-dependent	JJ
cord-017640-i8h48ny6	228	32	mode	mode	NN
cord-017640-i8h48ny6	228	33	of	of	IN
cord-017640-i8h48ny6	228	34	cell	cell	NN
cord-017640-i8h48ny6	228	35	migration	migration	NN
cord-017640-i8h48ny6	228	36	occurs	occur	VBZ
cord-017640-i8h48ny6	228	37	as	as	IN
cord-017640-i8h48ny6	228	38	an	an	DT
cord-017640-i8h48ny6	228	39	alternative	alternative	JJ
cord-017640-i8h48ny6	228	40	signal	signal	NN
cord-017640-i8h48ny6	228	41	for	for	IN
cord-017640-i8h48ny6	228	42	death	death	NN
cord-017640-i8h48ny6	228	43	receptors	receptor	NNS
cord-017640-i8h48ny6	228	44	or	or	CC
cord-017640-i8h48ny6	228	45	that	that	IN
cord-017640-i8h48ny6	228	46	it	-PRON-	PRP
cord-017640-i8h48ny6	228	47	only	only	RB
cord-017640-i8h48ny6	228	48	participates	participate	VBZ
cord-017640-i8h48ny6	228	49	in	in	IN
cord-017640-i8h48ny6	228	50	non	non	JJ
cord-017640-i8h48ny6	228	51	-	-	JJ
cord-017640-i8h48ny6	228	52	death	death	JJ
cord-017640-i8h48ny6	228	53	receptor	receptor	NN
cord-017640-i8h48ny6	228	54	-	-	HYPH
cord-017640-i8h48ny6	228	55	induced	induce	VBN
cord-017640-i8h48ny6	228	56	cell	cell	NN
cord-017640-i8h48ny6	228	57	motility	motility	NN
cord-017640-i8h48ny6	228	58	.	.	.
cord-017640-i8h48ny6	229	1	It	-PRON-	PRP
cord-017640-i8h48ny6	229	2	would	would	MD
cord-017640-i8h48ny6	229	3	be	be	VB
cord-017640-i8h48ny6	229	4	interesting	interesting	JJ
cord-017640-i8h48ny6	229	5	to	to	TO
cord-017640-i8h48ny6	229	6	address	address	VB
cord-017640-i8h48ny6	229	7	this	this	DT
cord-017640-i8h48ny6	229	8	question	question	NN
cord-017640-i8h48ny6	229	9	in	in	IN
cord-017640-i8h48ny6	229	10	the	the	DT
cord-017640-i8h48ny6	229	11	future	future	NN
cord-017640-i8h48ny6	229	12	.	.	.
cord-017640-i8h48ny6	230	1	To	to	IN
cord-017640-i8h48ny6	230	2	date	date	NN
cord-017640-i8h48ny6	230	3	,	,	,
cord-017640-i8h48ny6	230	4	it	-PRON-	PRP
cord-017640-i8h48ny6	230	5	can	can	MD
cord-017640-i8h48ny6	230	6	only	only	RB
cord-017640-i8h48ny6	230	7	be	be	VB
cord-017640-i8h48ny6	230	8	surmised	surmise	VBN
cord-017640-i8h48ny6	230	9	that	that	IN
cord-017640-i8h48ny6	230	10	phosphorylation	phosphorylation	NN
cord-017640-i8h48ny6	230	11	of	of	IN
cord-017640-i8h48ny6	230	12	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	230	13	at	at	IN
cord-017640-i8h48ny6	230	14	Y380	y380	RB
cord-017640-i8h48ny6	230	15	upon	upon	IN
cord-017640-i8h48ny6	230	16	EGFR	EGFR	NNP
cord-017640-i8h48ny6	230	17	stimulation	stimulation	NN
cord-017640-i8h48ny6	230	18	may	may	MD
cord-017640-i8h48ny6	230	19	prime	prime	VB
cord-017640-i8h48ny6	230	20	certain	certain	JJ
cord-017640-i8h48ny6	230	21	cancer	cancer	NN
cord-017640-i8h48ny6	230	22	cells	cell	NNS
cord-017640-i8h48ny6	230	23	to	to	TO
cord-017640-i8h48ny6	230	24	become	become	VB
cord-017640-i8h48ny6	230	25	unresponsive	unresponsive	JJ
cord-017640-i8h48ny6	230	26	to	to	IN
cord-017640-i8h48ny6	230	27	the	the	DT
cord-017640-i8h48ny6	230	28	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	230	29	signal	signal	NN
cord-017640-i8h48ny6	230	30	triggered	trigger	VBN
cord-017640-i8h48ny6	230	31	by	by	IN
cord-017640-i8h48ny6	230	32	cytotoxic	cytotoxic	JJ
cord-017640-i8h48ny6	230	33	CD95L	cd95l	NN
cord-017640-i8h48ny6	230	34	and	and	CC
cord-017640-i8h48ny6	230	35	meanwhile	meanwhile	RB
cord-017640-i8h48ny6	230	36	promote	promote	VB
cord-017640-i8h48ny6	230	37	cell	cell	NN
cord-017640-i8h48ny6	230	38	migration	migration	NN
cord-017640-i8h48ny6	230	39	,	,	,
cord-017640-i8h48ny6	230	40	an	an	DT
cord-017640-i8h48ny6	230	41	essential	essential	JJ
cord-017640-i8h48ny6	230	42	event	event	NN
cord-017640-i8h48ny6	230	43	in	in	IN
cord-017640-i8h48ny6	230	44	the	the	DT
cord-017640-i8h48ny6	230	45	course	course	NN
cord-017640-i8h48ny6	230	46	of	of	IN
cord-017640-i8h48ny6	230	47	cancer	cancer	NN
cord-017640-i8h48ny6	230	48	cell	cell	NN
cord-017640-i8h48ny6	230	49	metastasis	metastasis	NN
cord-017640-i8h48ny6	230	50	(	(	-LRB-
cord-017640-i8h48ny6	230	51	Fig	Fig	NNP
cord-017640-i8h48ny6	230	52	.	.	.
cord-017640-i8h48ny6	230	53	11.4	11.4	CD
cord-017640-i8h48ny6	230	54	)	)	-RRB-
cord-017640-i8h48ny6	230	55	.	.	.
cord-017640-i8h48ny6	231	1	It	-PRON-	PRP
cord-017640-i8h48ny6	231	2	is	be	VBZ
cord-017640-i8h48ny6	231	3	noteworthy	noteworthy	JJ
cord-017640-i8h48ny6	231	4	that	that	IN
cord-017640-i8h48ny6	231	5	in	in	IN
cord-017640-i8h48ny6	231	6	a	a	DT
cord-017640-i8h48ny6	231	7	similar	similar	JJ
cord-017640-i8h48ny6	231	8	manner	manner	NN
cord-017640-i8h48ny6	231	9	,	,	,
cord-017640-i8h48ny6	231	10	a	a	DT
cord-017640-i8h48ny6	231	11	decrease	decrease	NN
cord-017640-i8h48ny6	231	12	in	in	IN
cord-017640-i8h48ny6	231	13	the	the	DT
cord-017640-i8h48ny6	231	14	plasma	plasma	NN
cord-017640-i8h48ny6	231	15	membrane	membrane	NN
cord-017640-i8h48ny6	231	16	level	level	NN
cord-017640-i8h48ny6	231	17	of	of	IN
cord-017640-i8h48ny6	231	18	CD95	CD95	NNP
cord-017640-i8h48ny6	231	19	or	or	CC
cord-017640-i8h48ny6	231	20	expression	expression	NN
cord-017640-i8h48ny6	231	21	of	of	IN
cord-017640-i8h48ny6	231	22	a	a	DT
cord-017640-i8h48ny6	231	23	mutated	mutate	VBN
cord-017640-i8h48ny6	231	24	CD95	CD95	NNP
cord-017640-i8h48ny6	231	25	allele	allele	NN
cord-017640-i8h48ny6	231	26	,	,	,
cord-017640-i8h48ny6	231	27	as	as	IN
cord-017640-i8h48ny6	231	28	observed	observe	VBN
cord-017640-i8h48ny6	231	29	in	in	IN
cord-017640-i8h48ny6	231	30	ALPS	ALPS	NNP
cord-017640-i8h48ny6	231	31	patients	patient	NNS
cord-017640-i8h48ny6	231	32	and	and	CC
cord-017640-i8h48ny6	231	33	malignant	malignant	JJ
cord-017640-i8h48ny6	231	34	cells	cell	NNS
cord-017640-i8h48ny6	231	35	,	,	,
cord-017640-i8h48ny6	231	36	inhibits	inhibit	VBZ
cord-017640-i8h48ny6	231	37	the	the	DT
cord-017640-i8h48ny6	231	38	implementation	implementation	NN
cord-017640-i8h48ny6	231	39	of	of	IN
cord-017640-i8h48ny6	231	40	the	the	DT
cord-017640-i8h48ny6	231	41	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	231	42	signal	signal	NN
cord-017640-i8h48ny6	231	43	but	but	CC
cord-017640-i8h48ny6	231	44	does	do	VBZ
cord-017640-i8h48ny6	231	45	not	not	RB
cord-017640-i8h48ny6	231	46	affect	affect	VB
cord-017640-i8h48ny6	231	47	the	the	DT
cord-017640-i8h48ny6	231	48	transmission	transmission	NN
cord-017640-i8h48ny6	231	49	of	of	IN
cord-017640-i8h48ny6	231	50	non	non	JJ
cord-017640-i8h48ny6	231	51	-	-	JJ
cord-017640-i8h48ny6	231	52	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	231	53	signals	signal	NNS
cord-017640-i8h48ny6	231	54	,	,	,
cord-017640-i8h48ny6	231	55	such	such	JJ
cord-017640-i8h48ny6	231	56	as	as	IN
cord-017640-i8h48ny6	231	57	NF	NF	NNP
cord-017640-i8h48ny6	231	58	-	-	HYPH
cord-017640-i8h48ny6	231	59	κB	κB	NNP
cord-017640-i8h48ny6	231	60	,	,	,
cord-017640-i8h48ny6	231	61	MAPK	MAPK	NNP
cord-017640-i8h48ny6	231	62	,	,	,
cord-017640-i8h48ny6	231	63	and	and	CC
cord-017640-i8h48ny6	231	64	PI3	PI3	NNP
cord-017640-i8h48ny6	231	65	K	K	NNP
cord-017640-i8h48ny6	231	66	[	[	-LRB-
cord-017640-i8h48ny6	231	67	106	106	CD
cord-017640-i8h48ny6	231	68	,	,	,
cord-017640-i8h48ny6	231	69	107	107	CD
cord-017640-i8h48ny6	231	70	,	,	,
cord-017640-i8h48ny6	231	71	147	147	CD
cord-017640-i8h48ny6	231	72	]	]	-RRB-
cord-017640-i8h48ny6	231	73	,	,	,
cord-017640-i8h48ny6	231	74	suggesting	suggest	VBG
cord-017640-i8h48ny6	231	75	that	that	IN
cord-017640-i8h48ny6	231	76	these	these	DT
cord-017640-i8h48ny6	231	77	signals	signal	NNS
cord-017640-i8h48ny6	231	78	may	may	MD
cord-017640-i8h48ny6	231	79	stem	stem	VB
cord-017640-i8h48ny6	231	80	from	from	IN
cord-017640-i8h48ny6	231	81	a	a	DT
cord-017640-i8h48ny6	231	82	different	different	JJ
cord-017640-i8h48ny6	231	83	domain	domain	NN
cord-017640-i8h48ny6	231	84	than	than	IN
cord-017640-i8h48ny6	231	85	CD95-DD	cd95-dd	NN
cord-017640-i8h48ny6	231	86	or	or	CC
cord-017640-i8h48ny6	231	87	rely	rely	VB
cord-017640-i8h48ny6	231	88	on	on	IN
cord-017640-i8h48ny6	231	89	different	different	JJ
cord-017640-i8h48ny6	231	90	thresholds	threshold	NNS
cord-017640-i8h48ny6	231	91	to	to	TO
cord-017640-i8h48ny6	231	92	be	be	VB
cord-017640-i8h48ny6	231	93	elicited	elicit	VBN
cord-017640-i8h48ny6	231	94	.	.	.
cord-017640-i8h48ny6	232	1	In	in	IN
cord-017640-i8h48ny6	232	2	summary	summary	NN
cord-017640-i8h48ny6	232	3	,	,	,
cord-017640-i8h48ny6	232	4	although	although	IN
cord-017640-i8h48ny6	232	5	the	the	DT
cord-017640-i8h48ny6	232	6	CD95/	CD95/	NNPS
cord-017640-i8h48ny6	232	7	CD95L	cd95l	NN
cord-017640-i8h48ny6	232	8	interaction	interaction	NN
cord-017640-i8h48ny6	232	9	can	can	MD
cord-017640-i8h48ny6	232	10	eliminate	eliminate	VB
cord-017640-i8h48ny6	232	11	malignant	malignant	JJ
cord-017640-i8h48ny6	232	12	cells	cell	NNS
cord-017640-i8h48ny6	232	13	by	by	IN
cord-017640-i8h48ny6	232	14	implementation	implementation	NN
cord-017640-i8h48ny6	232	15	of	of	IN
cord-017640-i8h48ny6	232	16	the	the	DT
cord-017640-i8h48ny6	232	17	DISC	disc	NN
cord-017640-i8h48ny6	232	18	or	or	CC
cord-017640-i8h48ny6	232	19	can	can	MD
cord-017640-i8h48ny6	232	20	pro	pro	VB
cord-017640-i8h48ny6	232	21	-	-	JJ
cord-017640-i8h48ny6	232	22	mote	mote	JJ
cord-017640-i8h48ny6	232	23	carcinogenesis	carcinogenesis	NN
cord-017640-i8h48ny6	232	24	by	by	IN
cord-017640-i8h48ny6	232	25	sustaining	sustain	VBG
cord-017640-i8h48ny6	232	26	inflammation	inflammation	NN
cord-017640-i8h48ny6	232	27	and/or	and/or	CC
cord-017640-i8h48ny6	232	28	by	by	IN
cord-017640-i8h48ny6	232	29	inducing	induce	VBG
cord-017640-i8h48ny6	232	30	metastatic	metastatic	JJ
cord-017640-i8h48ny6	232	31	dissemination	dissemination	NN
cord-017640-i8h48ny6	232	32	[	[	-LRB-
cord-017640-i8h48ny6	232	33	50	50	CD
cord-017640-i8h48ny6	232	34	,	,	,
cord-017640-i8h48ny6	232	35	51	51	CD
cord-017640-i8h48ny6	232	36	,	,	,
cord-017640-i8h48ny6	232	37	53	53	CD
cord-017640-i8h48ny6	232	38	,	,	,
cord-017640-i8h48ny6	232	39	108	108	CD
cord-017640-i8h48ny6	232	40	,	,	,
cord-017640-i8h48ny6	232	41	147	147	CD
cord-017640-i8h48ny6	232	42	,	,	,
cord-017640-i8h48ny6	232	43	148	148	CD
cord-017640-i8h48ny6	232	44	,	,	,
cord-017640-i8h48ny6	232	45	161	161	CD
cord-017640-i8h48ny6	232	46	]	]	-RRB-
cord-017640-i8h48ny6	232	47	,	,	,
cord-017640-i8h48ny6	232	48	the	the	DT
cord-017640-i8h48ny6	232	49	molecular	molecular	JJ
cord-017640-i8h48ny6	232	50	mechanisms	mechanism	NNS
cord-017640-i8h48ny6	232	51	underlying	underlie	VBG
cord-017640-i8h48ny6	232	52	the	the	DT
cord-017640-i8h48ny6	232	53	switch	switch	NN
cord-017640-i8h48ny6	232	54	between	between	IN
cord-017640-i8h48ny6	232	55	these	these	DT
cord-017640-i8h48ny6	232	56	different	different	JJ
cord-017640-i8h48ny6	232	57	signaling	signal	VBG
cord-017640-i8h48ny6	232	58	pathways	pathway	NNS
cord-017640-i8h48ny6	232	59	remain	remain	VBP
cord-017640-i8h48ny6	232	60	enigmatic	enigmatic	JJ
cord-017640-i8h48ny6	232	61	.	.	.
cord-017640-i8h48ny6	233	1	An	an	DT
cord-017640-i8h48ny6	233	2	important	important	JJ
cord-017640-i8h48ny6	233	3	question	question	NN
cord-017640-i8h48ny6	233	4	to	to	TO
cord-017640-i8h48ny6	233	5	be	be	VB
cord-017640-i8h48ny6	233	6	addressed	address	VBN
cord-017640-i8h48ny6	233	7	is	be	VBZ
cord-017640-i8h48ny6	233	8	how	how	WRB
cord-017640-i8h48ny6	233	9	the	the	DT
cord-017640-i8h48ny6	233	10	magnitude	magnitude	NN
cord-017640-i8h48ny6	233	11	of	of	IN
cord-017640-i8h48ny6	233	12	CD95	CD95	NNP
cord-017640-i8h48ny6	233	13	aggregation	aggregation	NN
cord-017640-i8h48ny6	233	14	controls	control	VBZ
cord-017640-i8h48ny6	233	15	the	the	DT
cord-017640-i8h48ny6	233	16	formation	formation	NN
cord-017640-i8h48ny6	233	17	of	of	IN
cord-017640-i8h48ny6	233	18	"	"	``
cord-017640-i8h48ny6	233	19	death"-vs	death"-vs	FW
cord-017640-i8h48ny6	233	20	.	.	.
cord-017640-i8h48ny6	233	21	"	"	''
cord-017640-i8h48ny6	234	1	motility"-ISCs	motility"-iscs	UH
cord-017640-i8h48ny6	234	2	.	.	.
cord-017640-i8h48ny6	235	1	Addressing	address	VBG
cord-017640-i8h48ny6	235	2	these	these	DT
cord-017640-i8h48ny6	235	3	questions	question	NNS
cord-017640-i8h48ny6	235	4	will	will	MD
cord-017640-i8h48ny6	235	5	lead	lead	VB
cord-017640-i8h48ny6	235	6	to	to	IN
cord-017640-i8h48ny6	235	7	the	the	DT
cord-017640-i8h48ny6	235	8	development	development	NN
cord-017640-i8h48ny6	235	9	of	of	IN
cord-017640-i8h48ny6	235	10	new	new	JJ
cord-017640-i8h48ny6	235	11	therapeutic	therapeutic	JJ
cord-017640-i8h48ny6	235	12	agents	agent	NNS
cord-017640-i8h48ny6	235	13	with	with	IN
cord-017640-i8h48ny6	235	14	the	the	DT
cord-017640-i8h48ny6	235	15	ability	ability	NN
cord-017640-i8h48ny6	235	16	to	to	TO
cord-017640-i8h48ny6	235	17	contain	contain	VB
cord-017640-i8h48ny6	235	18	the	the	DT
cord-017640-i8h48ny6	235	19	spread	spread	NN
cord-017640-i8h48ny6	235	20	of	of	IN
cord-017640-i8h48ny6	235	21	inflammation	inflammation	NN
cord-017640-i8h48ny6	235	22	or	or	CC
cord-017640-i8h48ny6	235	23	impede	impede	VB
cord-017640-i8h48ny6	235	24	carcinogenesis	carcinogenesis	NN
cord-017640-i8h48ny6	235	25	at	at	IN
cord-017640-i8h48ny6	235	26	least	least	JJS
cord-017640-i8h48ny6	235	27	in	in	IN
cord-017640-i8h48ny6	235	28	pathologies	pathology	NNS
cord-017640-i8h48ny6	235	29	involving	involve	VBG
cord-017640-i8h48ny6	235	30	increased	increase	VBN
cord-017640-i8h48ny6	235	31	soluble	soluble	JJ
cord-017640-i8h48ny6	235	32	CD95L	cd95l	NN
cord-017640-i8h48ny6	235	33	such	such	JJ
cord-017640-i8h48ny6	235	34	as	as	IN
cord-017640-i8h48ny6	235	35	cancers	cancer	NNS
cord-017640-i8h48ny6	235	36	(	(	-LRB-
cord-017640-i8h48ny6	235	37	e.g.	e.g.	RB
cord-017640-i8h48ny6	235	38	,	,	,
cord-017640-i8h48ny6	235	39	pancreatic	pancreatic	JJ
cord-017640-i8h48ny6	235	40	cancer	cancer	NN
cord-017640-i8h48ny6	235	41	[	[	-LRB-
cord-017640-i8h48ny6	235	42	162	162	CD
cord-017640-i8h48ny6	235	43	]	]	-RRB-
cord-017640-i8h48ny6	235	44	,	,	,
cord-017640-i8h48ny6	235	45	large	large	JJ
cord-017640-i8h48ny6	235	46	granular	granular	JJ
cord-017640-i8h48ny6	235	47	lymphocytic	lymphocytic	JJ
cord-017640-i8h48ny6	235	48	leukemia	leukemia	NN
cord-017640-i8h48ny6	235	49	,	,	,
cord-017640-i8h48ny6	235	50	breast	breast	NN
cord-017640-i8h48ny6	235	51	cancer	cancer	NN
cord-017640-i8h48ny6	235	52	[	[	-LRB-
cord-017640-i8h48ny6	235	53	157	157	CD
cord-017640-i8h48ny6	235	54	]	]	-RRB-
cord-017640-i8h48ny6	235	55	,	,	,
cord-017640-i8h48ny6	235	56	and	and	CC
cord-017640-i8h48ny6	235	57	NK	NK	NNP
cord-017640-i8h48ny6	235	58	cell	cell	NN
cord-017640-i8h48ny6	235	59	lymphoma	lymphoma	NN
cord-017640-i8h48ny6	235	60	[	[	-LRB-
cord-017640-i8h48ny6	235	61	163	163	CD
cord-017640-i8h48ny6	235	62	]	]	-RRB-
cord-017640-i8h48ny6	235	63	)	)	-RRB-
cord-017640-i8h48ny6	235	64	or	or	CC
cord-017640-i8h48ny6	235	65	autoimmune	autoimmune	JJ
cord-017640-i8h48ny6	235	66	disorders	disorder	NNS
cord-017640-i8h48ny6	235	67	(	(	-LRB-
cord-017640-i8h48ny6	235	68	e.g.	e.g.	RB
cord-017640-i8h48ny6	235	69	,	,	,
cord-017640-i8h48ny6	235	70	rheumatoid	rheumatoid	NN
cord-017640-i8h48ny6	235	71	arthritis	arthritis	NN
cord-017640-i8h48ny6	235	72	and	and	CC
cord-017640-i8h48ny6	235	73	osteoarthritis	osteoarthritis	NN
cord-017640-i8h48ny6	235	74	[	[	-LRB-
cord-017640-i8h48ny6	235	75	164	164	CD
cord-017640-i8h48ny6	235	76	]	]	-RRB-
cord-017640-i8h48ny6	235	77	,	,	,
cord-017640-i8h48ny6	235	78	graft	graft	NN
cord-017640-i8h48ny6	235	79	-	-	HYPH
cord-017640-i8h48ny6	235	80	versus	versus	IN
cord-017640-i8h48ny6	235	81	-	-	HYPH
cord-017640-i8h48ny6	235	82	host	host	NN
cord-017640-i8h48ny6	235	83	-	-	HYPH
cord-017640-i8h48ny6	235	84	disease	disease	NN
cord-017640-i8h48ny6	235	85	(	(	-LRB-
cord-017640-i8h48ny6	235	86	GVHD	GVHD	NNP
cord-017640-i8h48ny6	235	87	)	)	-RRB-
cord-017640-i8h48ny6	235	88	[	[	-LRB-
cord-017640-i8h48ny6	235	89	165	165	CD
cord-017640-i8h48ny6	235	90	,	,	,
cord-017640-i8h48ny6	235	91	166	166	CD
cord-017640-i8h48ny6	235	92	]	]	-RRB-
cord-017640-i8h48ny6	235	93	,	,	,
cord-017640-i8h48ny6	235	94	or	or	CC
cord-017640-i8h48ny6	235	95	SLE	SLE	NNP
cord-017640-i8h48ny6	235	96	[	[	-LRB-
cord-017640-i8h48ny6	235	97	53	53	CD
cord-017640-i8h48ny6	235	98	,	,	,
cord-017640-i8h48ny6	235	99	167	167	CD
cord-017640-i8h48ny6	235	100	]	]	-RRB-
cord-017640-i8h48ny6	235	101	)	)	-RRB-
cord-017640-i8h48ny6	235	102	.	.	.
cord-017640-i8h48ny6	236	1	Altogether	altogether	RB
cord-017640-i8h48ny6	236	2	,	,	,
cord-017640-i8h48ny6	236	3	these	these	DT
cord-017640-i8h48ny6	236	4	studies	study	NNS
cord-017640-i8h48ny6	236	5	support	support	VBP
cord-017640-i8h48ny6	236	6	the	the	DT
cord-017640-i8h48ny6	236	7	notion	notion	NN
cord-017640-i8h48ny6	236	8	that	that	IN
cord-017640-i8h48ny6	236	9	the	the	DT
cord-017640-i8h48ny6	236	10	death	death	NN
cord-017640-i8h48ny6	236	11	function	function	NN
cord-017640-i8h48ny6	236	12	of	of	IN
cord-017640-i8h48ny6	236	13	CD95	CD95	NNP
cord-017640-i8h48ny6	236	14	may	may	MD
cord-017640-i8h48ny6	236	15	correspond	correspond	VB
cord-017640-i8h48ny6	236	16	to	to	IN
cord-017640-i8h48ny6	236	17	its	-PRON-	PRP$
cord-017640-i8h48ny6	236	18	"	"	``
cord-017640-i8h48ny6	236	19	day	day	NN
cord-017640-i8h48ny6	236	20	job	job	NN
cord-017640-i8h48ny6	236	21	,	,	,
cord-017640-i8h48ny6	236	22	"	"	''
cord-017640-i8h48ny6	236	23	while	while	IN
cord-017640-i8h48ny6	236	24	the	the	DT
cord-017640-i8h48ny6	236	25	receptor	receptor	NN
cord-017640-i8h48ny6	236	26	may	may	MD
cord-017640-i8h48ny6	236	27	act	act	VB
cord-017640-i8h48ny6	236	28	as	as	IN
cord-017640-i8h48ny6	236	29	"	"	``
cord-017640-i8h48ny6	236	30	a	a	DT
cord-017640-i8h48ny6	236	31	night	night	NN
cord-017640-i8h48ny6	236	32	killer	killer	NN
cord-017640-i8h48ny6	236	33	"	"	''
cord-017640-i8h48ny6	237	1	In	in	IN
cord-017640-i8h48ny6	237	2	the	the	DT
cord-017640-i8h48ny6	237	3	presence	presence	NN
cord-017640-i8h48ny6	237	4	of	of	IN
cord-017640-i8h48ny6	237	5	cl	cl	NNP
cord-017640-i8h48ny6	237	6	-	-	HYPH
cord-017640-i8h48ny6	237	7	CD95L	CD95L	NNP
cord-017640-i8h48ny6	237	8	,	,	,
cord-017640-i8h48ny6	237	9	CD95	CD95	NNP
cord-017640-i8h48ny6	237	10	triggers	trigger	VBZ
cord-017640-i8h48ny6	237	11	MISC	MISC	NNP
cord-017640-i8h48ny6	237	12	formation	formation	NN
cord-017640-i8h48ny6	237	13	.	.	.
cord-017640-i8h48ny6	238	1	This	this	DT
cord-017640-i8h48ny6	238	2	complex	complex	NN
cord-017640-i8h48ny6	238	3	is	be	VBZ
cord-017640-i8h48ny6	238	4	devoid	devoid	JJ
cord-017640-i8h48ny6	238	5	of	of	IN
cord-017640-i8h48ny6	238	6	FADD	FADD	NNP
cord-017640-i8h48ny6	238	7	and	and	CC
cord-017640-i8h48ny6	238	8	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	238	9	,	,	,
cord-017640-i8h48ny6	238	10	but	but	CC
cord-017640-i8h48ny6	238	11	,	,	,
cord-017640-i8h48ny6	238	12	instead	instead	RB
cord-017640-i8h48ny6	238	13	,	,	,
cord-017640-i8h48ny6	238	14	recruits	recruit	VBZ
cord-017640-i8h48ny6	238	15	the	the	DT
cord-017640-i8h48ny6	238	16	src	src	NNP
cord-017640-i8h48ny6	238	17	kinase	kinase	NNP
cord-017640-i8h48ny6	238	18	c	c	NNP
cord-017640-i8h48ny6	238	19	-	-	:
cord-017640-i8h48ny6	238	20	yes	yes	UH
cord-017640-i8h48ny6	238	21	that	that	WDT
cord-017640-i8h48ny6	238	22	implements	implement	VBZ
cord-017640-i8h48ny6	238	23	the	the	DT
cord-017640-i8h48ny6	238	24	PI3	pi3	NN
cord-017640-i8h48ny6	238	25	K	K	NNP
cord-017640-i8h48ny6	238	26	signaling	signal	VBG
cord-017640-i8h48ny6	238	27	pathway	pathway	NN
cord-017640-i8h48ny6	238	28	.	.	.
cord-017640-i8h48ny6	239	1	CD95	CD95	NNP
cord-017640-i8h48ny6	239	2	engagement	engagement	NN
cord-017640-i8h48ny6	239	3	is	be	VBZ
cord-017640-i8h48ny6	239	4	also	also	RB
cord-017640-i8h48ny6	239	5	capable	capable	JJ
cord-017640-i8h48ny6	239	6	of	of	IN
cord-017640-i8h48ny6	239	7	NF	nf	NN
cord-017640-i8h48ny6	239	8	-	-	HYPH
cord-017640-i8h48ny6	239	9	κB	κB	NNP
cord-017640-i8h48ny6	239	10	and	and	CC
cord-017640-i8h48ny6	239	11	MAPK	MAPK	NNP
cord-017640-i8h48ny6	239	12	activations	activation	NNS
cord-017640-i8h48ny6	239	13	through	through	IN
cord-017640-i8h48ny6	239	14	a	a	DT
cord-017640-i8h48ny6	239	15	yet	yet	RB
cord-017640-i8h48ny6	239	16	unknown	unknown	JJ
cord-017640-i8h48ny6	239	17	mechanism	mechanism	NN
cord-017640-i8h48ny6	239	18	.	.	.
cord-017640-i8h48ny6	240	1	Right	right	JJ
cord-017640-i8h48ny6	240	2	panel	panel	NN
cord-017640-i8h48ny6	240	3	:	:	:
cord-017640-i8h48ny6	240	4	It	-PRON-	PRP
cord-017640-i8h48ny6	240	5	was	be	VBD
cord-017640-i8h48ny6	240	6	reported	report	VBN
cord-017640-i8h48ny6	240	7	that	that	IN
cord-017640-i8h48ny6	240	8	procaspase-8	procaspase-8	NNP
cord-017640-i8h48ny6	240	9	can	can	MD
cord-017640-i8h48ny6	240	10	be	be	VB
cord-017640-i8h48ny6	240	11	phosphorylated	phosphorylate	VBN
cord-017640-i8h48ny6	240	12	by	by	IN
cord-017640-i8h48ny6	240	13	the	the	DT
cord-017640-i8h48ny6	240	14	tyrosine	tyrosine	NN
cord-017640-i8h48ny6	240	15	kinase	kinase	VBN
cord-017640-i8h48ny6	240	16	src	src	NNP
cord-017640-i8h48ny6	240	17	upon	upon	IN
cord-017640-i8h48ny6	240	18	EGFR	EGFR	NNP
cord-017640-i8h48ny6	240	19	stimulation	stimulation	NN
cord-017640-i8h48ny6	240	20	.	.	.
cord-017640-i8h48ny6	241	1	This	this	DT
cord-017640-i8h48ny6	241	2	posttranslational	posttranslational	JJ
cord-017640-i8h48ny6	241	3	modification	modification	NN
cord-017640-i8h48ny6	241	4	not	not	RB
cord-017640-i8h48ny6	241	5	only	only	RB
cord-017640-i8h48ny6	241	6	blocks	block	VBZ
cord-017640-i8h48ny6	241	7	the	the	DT
cord-017640-i8h48ny6	241	8	catalytic	catalytic	JJ
cord-017640-i8h48ny6	241	9	activity	activity	NN
cord-017640-i8h48ny6	241	10	of	of	IN
cord-017640-i8h48ny6	241	11	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	241	12	but	but	CC
cord-017640-i8h48ny6	241	13	also	also	RB
cord-017640-i8h48ny6	241	14	promotes	promote	VBZ
cord-017640-i8h48ny6	241	15	the	the	DT
cord-017640-i8h48ny6	241	16	recruitment	recruitment	NN
cord-017640-i8h48ny6	241	17	of	of	IN
cord-017640-i8h48ny6	241	18	the	the	DT
cord-017640-i8h48ny6	241	19	p85	p85	NN
cord-017640-i8h48ny6	241	20	subunit	subunit	NN
cord-017640-i8h48ny6	241	21	of	of	IN
cord-017640-i8h48ny6	241	22	PI3K.	PI3K.	NNP
cord-017640-i8h48ny6	242	1	We	-PRON-	PRP
cord-017640-i8h48ny6	242	2	surmise	surmise	VBP
cord-017640-i8h48ny6	242	3	that	that	IN
cord-017640-i8h48ny6	242	4	this	this	DT
cord-017640-i8h48ny6	242	5	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	242	6	phosphorylation	phosphorylation	NN
cord-017640-i8h48ny6	242	7	may	may	MD
cord-017640-i8h48ny6	242	8	favor	favor	VB
cord-017640-i8h48ny6	242	9	the	the	DT
cord-017640-i8h48ny6	242	10	nonapoptotic	nonapoptotic	JJ
cord-017640-i8h48ny6	242	11	signals	signal	NNS
cord-017640-i8h48ny6	242	12	induced	induce	VBN
cord-017640-i8h48ny6	242	13	by	by	IN
cord-017640-i8h48ny6	242	14	CD95	CD95	NNP
cord-017640-i8h48ny6	242	15	by	by	IN
cord-017640-i8h48ny6	242	16	fueling	fuel	VBG
cord-017640-i8h48ny6	242	17	inflammation	inflammation	NN
cord-017640-i8h48ny6	242	18	in	in	IN
cord-017640-i8h48ny6	242	19	certain	certain	JJ
cord-017640-i8h48ny6	242	20	pathophysiological	pathophysiological	JJ
cord-017640-i8h48ny6	242	21	contexts	context	NNS
cord-017640-i8h48ny6	242	22	.	.	.
cord-017640-i8h48ny6	243	1	Strikingly	strikingly	RB
cord-017640-i8h48ny6	243	2	,	,	,
cord-017640-i8h48ny6	243	3	while	while	IN
cord-017640-i8h48ny6	243	4	the	the	DT
cord-017640-i8h48ny6	243	5	soluble	soluble	JJ
cord-017640-i8h48ny6	243	6	form	form	NN
cord-017640-i8h48ny6	243	7	of	of	IN
cord-017640-i8h48ny6	243	8	CD95L	cd95l	NN
cord-017640-i8h48ny6	243	9	generated	generate	VBN
cord-017640-i8h48ny6	243	10	by	by	IN
cord-017640-i8h48ny6	243	11	MMP7	MMP7	NNP
cord-017640-i8h48ny6	244	1	(	(	-LRB-
cord-017640-i8h48ny6	244	2	cleavage	cleavage	NN
cord-017640-i8h48ny6	244	3	site	site	NN
cord-017640-i8h48ny6	244	4	inside	inside	IN
cord-017640-i8h48ny6	244	5	the	the	DT
cord-017640-i8h48ny6	244	6	113	113	CD
cord-017640-i8h48ny6	244	7	ELR	ELR	NNP
cord-017640-i8h48ny6	244	8	115	115	CD
cord-017640-i8h48ny6	244	9	sequence	sequence	NN
cord-017640-i8h48ny6	244	10	,	,	,
cord-017640-i8h48ny6	244	11	Fig	Fig	NNP
cord-017640-i8h48ny6	244	12	.	.	.
cord-017640-i8h48ny6	245	1	11	11	CD
cord-017640-i8h48ny6	245	2	.5	.5	CD
cord-017640-i8h48ny6	245	3	)	)	-RRB-
cord-017640-i8h48ny6	246	1	induces	induce	VBZ
cord-017640-i8h48ny6	246	2	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	246	3	[	[	-LRB-
cord-017640-i8h48ny6	246	4	150	150	CD
cord-017640-i8h48ny6	246	5	]	]	-RRB-
cord-017640-i8h48ny6	246	6	,	,	.
cord-017640-i8h48ny6	247	1	its	-PRON-	PRP$
cord-017640-i8h48ny6	247	2	counterpart	counterpart	NN
cord-017640-i8h48ny6	247	3	processed	process	VBN
cord-017640-i8h48ny6	247	4	between	between	IN
cord-017640-i8h48ny6	247	5	serine	serine	NN
cord-017640-i8h48ny6	247	6	126	126	CD
cord-017640-i8h48ny6	247	7	and	and	CC
cord-017640-i8h48ny6	247	8	leucine	leucine	NN
cord-017640-i8h48ny6	247	9	127	127	CD
cord-017640-i8h48ny6	247	10	does	do	VBZ
cord-017640-i8h48ny6	247	11	not	not	RB
cord-017640-i8h48ny6	247	12	[	[	-LRB-
cord-017640-i8h48ny6	247	13	51	51	CD
cord-017640-i8h48ny6	247	14	,	,	,
cord-017640-i8h48ny6	247	15	53	53	CD
cord-017640-i8h48ny6	247	16	,	,	,
cord-017640-i8h48ny6	247	17	155	155	CD
cord-017640-i8h48ny6	247	18	]	]	-RRB-
cord-017640-i8h48ny6	247	19	.	.	.
cord-017640-i8h48ny6	248	1	To	to	TO
cord-017640-i8h48ny6	248	2	explain	explain	VB
cord-017640-i8h48ny6	248	3	this	this	DT
cord-017640-i8h48ny6	248	4	discrepancy	discrepancy	NN
cord-017640-i8h48ny6	248	5	,	,	,
cord-017640-i8h48ny6	248	6	one	one	PRP
cord-017640-i8h48ny6	248	7	may	may	MD
cord-017640-i8h48ny6	248	8	speculate	speculate	VB
cord-017640-i8h48ny6	248	9	that	that	IN
cord-017640-i8h48ny6	248	10	the	the	DT
cord-017640-i8h48ny6	248	11	different	different	JJ
cord-017640-i8h48ny6	248	12	quaternary	quaternary	JJ
cord-017640-i8h48ny6	248	13	structures	structure	NNS
cord-017640-i8h48ny6	248	14	of	of	IN
cord-017640-i8h48ny6	248	15	the	the	DT
cord-017640-i8h48ny6	248	16	naturally	naturally	RB
cord-017640-i8h48ny6	248	17	processed	process	VBN
cord-017640-i8h48ny6	248	18	CD95L	CD95L	NNS
cord-017640-i8h48ny6	248	19	underlie	underlie	VBP
cord-017640-i8h48ny6	248	20	the	the	DT
cord-017640-i8h48ny6	248	21	implementation	implementation	NN
cord-017640-i8h48ny6	248	22	of	of	IN
cord-017640-i8h48ny6	248	23	"	"	``
cord-017640-i8h48ny6	248	24	death"-vs	death"-vs	FW
cord-017640-i8h48ny6	248	25	.	.	.
cord-017640-i8h48ny6	249	1	"	"	``
cord-017640-i8h48ny6	249	2	non	non	JJ
cord-017640-i8h48ny6	249	3	-	-	JJ
cord-017640-i8h48ny6	249	4	death"-inducing	death"-inducing	JJ
cord-017640-i8h48ny6	249	5	signaling	signal	VBG
cord-017640-i8h48ny6	249	6	complexes	complex	NNS
cord-017640-i8h48ny6	249	7	and	and	CC
cord-017640-i8h48ny6	249	8	downstream	downstream	JJ
cord-017640-i8h48ny6	249	9	signals	signal	NNS
cord-017640-i8h48ny6	249	10	.	.	.
cord-017640-i8h48ny6	250	1	In	in	IN
cord-017640-i8h48ny6	250	2	agreement	agreement	NN
cord-017640-i8h48ny6	250	3	with	with	IN
cord-017640-i8h48ny6	250	4	this	this	DT
cord-017640-i8h48ny6	250	5	notion	notion	NN
cord-017640-i8h48ny6	250	6	,	,	,
cord-017640-i8h48ny6	250	7	soluble	soluble	JJ
cord-017640-i8h48ny6	250	8	CD95L	cd95l	NN
cord-017640-i8h48ny6	250	9	bathed	bathe	VBN
cord-017640-i8h48ny6	250	10	in	in	IN
cord-017640-i8h48ny6	250	11	the	the	DT
cord-017640-i8h48ny6	250	12	bronchoalveolar	bronchoalveolar	NNP
cord-017640-i8h48ny6	250	13	lavage	lavage	NNP
cord-017640-i8h48ny6	250	14	(	(	-LRB-
cord-017640-i8h48ny6	250	15	BALs	BALs	NNP
cord-017640-i8h48ny6	250	16	)	)	-RRB-
cord-017640-i8h48ny6	250	17	of	of	IN
cord-017640-i8h48ny6	250	18	patients	patient	NNS
cord-017640-i8h48ny6	250	19	suffering	suffer	VBG
cord-017640-i8h48ny6	250	20	from	from	IN
cord-017640-i8h48ny6	250	21	acute	acute	JJ
cord-017640-i8h48ny6	250	22	respiratory	respiratory	JJ
cord-017640-i8h48ny6	250	23	distress	distress	NN
cord-017640-i8h48ny6	250	24	syndrome	syndrome	NN
cord-017640-i8h48ny6	250	25	(	(	-LRB-
cord-017640-i8h48ny6	250	26	ARDS	ARDS	NNP
cord-017640-i8h48ny6	250	27	)	)	-RRB-
cord-017640-i8h48ny6	250	28	undergoes	undergo	VBZ
cord-017640-i8h48ny6	250	29	oxidation	oxidation	NN
cord-017640-i8h48ny6	250	30	at	at	IN
cord-017640-i8h48ny6	250	31	methionines	methionines	NNP
cord-017640-i8h48ny6	250	32	224	224	CD
cord-017640-i8h48ny6	250	33	and	and	CC
cord-017640-i8h48ny6	250	34	225	225	CD
cord-017640-i8h48ny6	250	35	(	(	-LRB-
cord-017640-i8h48ny6	250	36	Fig	fig	NN
cord-017640-i8h48ny6	250	37	.	.	.
cord-017640-i8h48ny6	251	1	11	11	CD
cord-017640-i8h48ny6	251	2	.5	.5	CD
cord-017640-i8h48ny6	251	3	)	)	-RRB-
cord-017640-i8h48ny6	251	4	,	,	,
cord-017640-i8h48ny6	251	5	which	which	WDT
cord-017640-i8h48ny6	251	6	enhances	enhance	VBZ
cord-017640-i8h48ny6	251	7	the	the	DT
cord-017640-i8h48ny6	251	8	aggregation	aggregation	NN
cord-017640-i8h48ny6	251	9	level	level	NN
cord-017640-i8h48ny6	251	10	of	of	IN
cord-017640-i8h48ny6	251	11	the	the	DT
cord-017640-i8h48ny6	251	12	soluble	soluble	JJ
cord-017640-i8h48ny6	251	13	ligand	ligand	NN
cord-017640-i8h48ny6	251	14	followed	follow	VBN
cord-017640-i8h48ny6	251	15	by	by	IN
cord-017640-i8h48ny6	251	16	its	-PRON-	PRP$
cord-017640-i8h48ny6	251	17	cytotoxic	cytotoxic	JJ
cord-017640-i8h48ny6	251	18	activity	activity	NN
cord-017640-i8h48ny6	251	19	[	[	-LRB-
cord-017640-i8h48ny6	251	20	168	168	CD
cord-017640-i8h48ny6	251	21	]	]	-RRB-
cord-017640-i8h48ny6	251	22	.	.	.
cord-017640-i8h48ny6	252	1	The	the	DT
cord-017640-i8h48ny6	252	2	same	same	JJ
cord-017640-i8h48ny6	252	3	authors	author	NNS
cord-017640-i8h48ny6	252	4	observed	observe	VBD
cord-017640-i8h48ny6	252	5	that	that	IN
cord-017640-i8h48ny6	252	6	the	the	DT
cord-017640-i8h48ny6	252	7	stalk	stalk	NN
cord-017640-i8h48ny6	252	8	region	region	NN
cord-017640-i8h48ny6	252	9	of	of	IN
cord-017640-i8h48ny6	252	10	CD95L	cd95l	NN
cord-017640-i8h48ny6	252	11	,	,	,
cord-017640-i8h48ny6	252	12	corresponding	correspond	VBG
cord-017640-i8h48ny6	252	13	to	to	IN
cord-017640-i8h48ny6	252	14	amino	amino	JJ
cord-017640-i8h48ny6	252	15	acids	acid	NNS
cord-017640-i8h48ny6	252	16	103	103	CD
cord-017640-i8h48ny6	252	17	-	-	SYM
cord-017640-i8h48ny6	252	18	136	136	CD
cord-017640-i8h48ny6	252	19	and	and	CC
cord-017640-i8h48ny6	252	20	encompassing	encompass	VBG
cord-017640-i8h48ny6	252	21	the	the	DT
cord-017640-i8h48ny6	252	22	metalloprotease	metalloprotease	NNP
cord-017640-i8h48ny6	252	23	cleavage	cleavage	NN
cord-017640-i8h48ny6	252	24	sites	site	NNS
cord-017640-i8h48ny6	252	25	(	(	-LRB-
cord-017640-i8h48ny6	252	26	Fig	Fig	NNP
cord-017640-i8h48ny6	252	27	.	.	.
cord-017640-i8h48ny6	252	28	11	11	CD
cord-017640-i8h48ny6	252	29	.5	.5	CD
cord-017640-i8h48ny6	252	30	)	)	-RRB-
cord-017640-i8h48ny6	252	31	,	,	,
cord-017640-i8h48ny6	252	32	participates	participate	VBZ
cord-017640-i8h48ny6	252	33	in	in	IN
cord-017640-i8h48ny6	252	34	the	the	DT
cord-017640-i8h48ny6	252	35	multimerization	multimerization	NN
cord-017640-i8h48ny6	252	36	of	of	IN
cord-017640-i8h48ny6	252	37	CD95L	CD95L	NNP
cord-017640-i8h48ny6	252	38	,	,	,
cord-017640-i8h48ny6	252	39	which	which	WDT
cord-017640-i8h48ny6	252	40	accounts	account	VBZ
cord-017640-i8h48ny6	252	41	for	for	IN
cord-017640-i8h48ny6	252	42	the	the	DT
cord-017640-i8h48ny6	252	43	damage	damage	NN
cord-017640-i8h48ny6	252	44	of	of	IN
cord-017640-i8h48ny6	252	45	the	the	DT
cord-017640-i8h48ny6	252	46	lung	lung	NN
cord-017640-i8h48ny6	252	47	epithelium	epithelium	NN
cord-017640-i8h48ny6	252	48	in	in	IN
cord-017640-i8h48ny6	252	49	ARDS	ARDS	NNP
cord-017640-i8h48ny6	252	50	[	[	-LRB-
cord-017640-i8h48ny6	252	51	168	168	CD
cord-017640-i8h48ny6	252	52	]	]	-RRB-
cord-017640-i8h48ny6	252	53	.	.	.
cord-017640-i8h48ny6	253	1	Of	of	IN
cord-017640-i8h48ny6	253	2	note	note	VB
cord-017640-i8h48ny6	253	3	,	,	,
cord-017640-i8h48ny6	253	4	in	in	IN
cord-017640-i8h48ny6	253	5	ARDS	ARDS	NNP
cord-017640-i8h48ny6	253	6	BALs	BALs	NNP
cord-017640-i8h48ny6	253	7	,	,	,
cord-017640-i8h48ny6	253	8	additional	additional	JJ
cord-017640-i8h48ny6	253	9	oxidation	oxidation	NN
cord-017640-i8h48ny6	253	10	occurs	occur	VBZ
cord-017640-i8h48ny6	253	11	at	at	IN
cord-017640-i8h48ny6	253	12	methionine	methionine	NN
cord-017640-i8h48ny6	253	13	121	121	CD
cord-017640-i8h48ny6	254	1	(	(	-LRB-
cord-017640-i8h48ny6	254	2	Fig	Fig	NNP
cord-017640-i8h48ny6	254	3	.	.	.
cord-017640-i8h48ny6	255	1	11	11	CD
cord-017640-i8h48ny6	255	2	.5	.5	CD
cord-017640-i8h48ny6	255	3	)	)	-RRB-
cord-017640-i8h48ny6	255	4	,	,	,
cord-017640-i8h48ny6	255	5	which	which	WDT
cord-017640-i8h48ny6	255	6	in	in	IN
cord-017640-i8h48ny6	255	7	turn	turn	NN
cord-017640-i8h48ny6	255	8	prevents	prevent	VBZ
cord-017640-i8h48ny6	255	9	the	the	DT
cord-017640-i8h48ny6	255	10	processing	processing	NN
cord-017640-i8h48ny6	255	11	of	of	IN
cord-017640-i8h48ny6	255	12	CD95L	cd95l	NN
cord-017640-i8h48ny6	255	13	by	by	IN
cord-017640-i8h48ny6	255	14	MMP7	MMP7	NNP
cord-017640-i8h48ny6	255	15	,	,	,
cord-017640-i8h48ny6	255	16	and	and	CC
cord-017640-i8h48ny6	255	17	explains	explain	VBZ
cord-017640-i8h48ny6	255	18	why	why	WRB
cord-017640-i8h48ny6	255	19	this	this	DT
cord-017640-i8h48ny6	255	20	cytotoxic	cytotoxic	JJ
cord-017640-i8h48ny6	255	21	ligand	ligand	NN
cord-017640-i8h48ny6	255	22	keeps	keep	VBZ
cord-017640-i8h48ny6	255	23	its	-PRON-	PRP$
cord-017640-i8h48ny6	255	24	stalk	stalk	NN
cord-017640-i8h48ny6	255	25	region	region	NN
cord-017640-i8h48ny6	255	26	[	[	-LRB-
cord-017640-i8h48ny6	255	27	168	168	CD
cord-017640-i8h48ny6	255	28	]	]	-RRB-
cord-017640-i8h48ny6	255	29	.	.	.
cord-017640-i8h48ny6	256	1	Nonetheless	nonetheless	RB
cord-017640-i8h48ny6	256	2	,	,	,
cord-017640-i8h48ny6	256	3	preservation	preservation	NN
cord-017640-i8h48ny6	256	4	of	of	IN
cord-017640-i8h48ny6	256	5	this	this	DT
cord-017640-i8h48ny6	256	6	region	region	NN
cord-017640-i8h48ny6	256	7	in	in	IN
cord-017640-i8h48ny6	256	8	soluble	soluble	JJ
cord-017640-i8h48ny6	256	9	CD95L	cd95l	NN
cord-017640-i8h48ny6	256	10	raises	raise	VBZ
cord-017640-i8h48ny6	256	11	the	the	DT
cord-017640-i8h48ny6	256	12	question	question	NN
cord-017640-i8h48ny6	256	13	that	that	IN
cord-017640-i8h48ny6	256	14	whether	whether	IN
cord-017640-i8h48ny6	256	15	an	an	DT
cord-017640-i8h48ny6	256	16	unidentified	unidentified	JJ
cord-017640-i8h48ny6	256	17	MMP7-independent	MMP7-independent	NNP
cord-017640-i8h48ny6	256	18	cleavage	cleavage	NN
cord-017640-i8h48ny6	256	19	site	site	NN
cord-017640-i8h48ny6	256	20	exists	exist	VBZ
cord-017640-i8h48ny6	256	21	in	in	IN
cord-017640-i8h48ny6	256	22	the	the	DT
cord-017640-i8h48ny6	256	23	juxtamembrane	juxtamembrane	NNP
cord-017640-i8h48ny6	256	24	region	region	NN
cord-017640-i8h48ny6	256	25	of	of	IN
cord-017640-i8h48ny6	256	26	CD95L	CD95L	NNP
cord-017640-i8h48ny6	256	27	,	,	,
cord-017640-i8h48ny6	256	28	near	near	IN
cord-017640-i8h48ny6	256	29	the	the	DT
cord-017640-i8h48ny6	256	30	plasma	plasma	NN
cord-017640-i8h48ny6	256	31	membrane	membrane	NN
cord-017640-i8h48ny6	256	32	,	,	,
cord-017640-i8h48ny6	256	33	or	or	CC
cord-017640-i8h48ny6	256	34	the	the	DT
cord-017640-i8h48ny6	256	35	ligand	ligand	NN
cord-017640-i8h48ny6	256	36	detected	detect	VBN
cord-017640-i8h48ny6	256	37	in	in	IN
cord-017640-i8h48ny6	256	38	ARDS	ARDS	NNP
cord-017640-i8h48ny6	256	39	patients	patient	NNS
cord-017640-i8h48ny6	256	40	corresponds	correspond	VBZ
cord-017640-i8h48ny6	256	41	to	to	IN
cord-017640-i8h48ny6	256	42	the	the	DT
cord-017640-i8h48ny6	256	43	full	full	JJ
cord-017640-i8h48ny6	256	44	-	-	HYPH
cord-017640-i8h48ny6	256	45	length	length	NN
cord-017640-i8h48ny6	256	46	CD95L	cd95l	NN
cord-017640-i8h48ny6	256	47	embedded	embed	VBN
cord-017640-i8h48ny6	256	48	in	in	IN
cord-017640-i8h48ny6	256	49	exosomes	exosomes	NNP
cord-017640-i8h48ny6	256	50	[	[	-LRB-
cord-017640-i8h48ny6	256	51	169	169	CD
cord-017640-i8h48ny6	256	52	,	,	,
cord-017640-i8h48ny6	256	53	170	170	CD
cord-017640-i8h48ny6	256	54	]	]	-RRB-
cord-017640-i8h48ny6	256	55	.	.	.
cord-017640-i8h48ny6	257	1	Indeed	indeed	RB
cord-017640-i8h48ny6	257	2	,	,	,
cord-017640-i8h48ny6	257	3	this	this	DT
cord-017640-i8h48ny6	257	4	peculiar	peculiar	JJ
cord-017640-i8h48ny6	257	5	exosome	exosome	NN
cord-017640-i8h48ny6	257	6	-	-	HYPH
cord-017640-i8h48ny6	257	7	bound	bind	VBN
cord-017640-i8h48ny6	257	8	CD95L	cd95l	NN
cord-017640-i8h48ny6	257	9	can	can	MD
cord-017640-i8h48ny6	257	10	be	be	VB
cord-017640-i8h48ny6	257	11	expressed	express	VBN
cord-017640-i8h48ny6	257	12	by	by	IN
cord-017640-i8h48ny6	257	13	human	human	JJ
cord-017640-i8h48ny6	257	14	prostate	prostate	NN
cord-017640-i8h48ny6	257	15	cancer	cancer	NN
cord-017640-i8h48ny6	257	16	cells	cell	NNS
cord-017640-i8h48ny6	257	17	(	(	-LRB-
cord-017640-i8h48ny6	257	18	i.e.	i.e.	FW
cord-017640-i8h48ny6	257	19	,	,	,
cord-017640-i8h48ny6	257	20	LNCaP	lncap	ADD
cord-017640-i8h48ny6	257	21	)	)	-RRB-
cord-017640-i8h48ny6	257	22	and	and	CC
cord-017640-i8h48ny6	257	23	evokes	evoke	VBZ
cord-017640-i8h48ny6	257	24	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	257	25	in	in	IN
cord-017640-i8h48ny6	257	26	activated	activate	VBN
cord-017640-i8h48ny6	257	27	T	t	NN
cord-017640-i8h48ny6	257	28	-	-	HYPH
cord-017640-i8h48ny6	257	29	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	257	30	[	[	-LRB-
cord-017640-i8h48ny6	257	31	171	171	CD
cord-017640-i8h48ny6	257	32	]	]	-RRB-
cord-017640-i8h48ny6	257	33	.	.	.
cord-017640-i8h48ny6	258	1	Overall	overall	RB
cord-017640-i8h48ny6	258	2	,	,	,
cord-017640-i8h48ny6	258	3	these	these	DT
cord-017640-i8h48ny6	258	4	findings	finding	NNS
cord-017640-i8h48ny6	258	5	emphasize	emphasize	VBP
cord-017640-i8h48ny6	258	6	that	that	IN
cord-017640-i8h48ny6	258	7	it	-PRON-	PRP
cord-017640-i8h48ny6	258	8	will	will	MD
cord-017640-i8h48ny6	258	9	be	be	VB
cord-017640-i8h48ny6	258	10	of	of	IN
cord-017640-i8h48ny6	258	11	great	great	JJ
cord-017640-i8h48ny6	258	12	interest	interest	NN
cord-017640-i8h48ny6	258	13	in	in	IN
cord-017640-i8h48ny6	258	14	the	the	DT
cord-017640-i8h48ny6	258	15	future	future	NN
cord-017640-i8h48ny6	258	16	to	to	TO
cord-017640-i8h48ny6	258	17	finely	finely	RB
cord-017640-i8h48ny6	258	18	characterize	characterize	VB
cord-017640-i8h48ny6	258	19	the	the	DT
cord-017640-i8h48ny6	258	20	quaternary	quaternary	JJ
cord-017640-i8h48ny6	258	21	structure	structure	NN
cord-017640-i8h48ny6	258	22	of	of	IN
cord-017640-i8h48ny6	258	23	the	the	DT
cord-017640-i8h48ny6	258	24	naturally	naturally	RB
cord-017640-i8h48ny6	258	25	processed	process	VBN
cord-017640-i8h48ny6	258	26	CD95L	CD95L	NNS
cord-017640-i8h48ny6	258	27	from	from	IN
cord-017640-i8h48ny6	258	28	the	the	DT
cord-017640-i8h48ny6	258	29	sera	sera	NNP
cord-017640-i8h48ny6	258	30	of	of	IN
cord-017640-i8h48ny6	258	31	patients	patient	NNS
cord-017640-i8h48ny6	258	32	affected	affect	VBN
cord-017640-i8h48ny6	258	33	by	by	IN
cord-017640-i8h48ny6	258	34	cancers	cancer	NNS
cord-017640-i8h48ny6	258	35	or	or	CC
cord-017640-i8h48ny6	258	36	chronic	chronic	JJ
cord-017640-i8h48ny6	258	37	/	/	SYM
cord-017640-i8h48ny6	258	38	acute	acute	JJ
cord-017640-i8h48ny6	258	39	inflammatory	inflammatory	JJ
cord-017640-i8h48ny6	258	40	disorders	disorder	NNS
cord-017640-i8h48ny6	258	41	,	,	,
cord-017640-i8h48ny6	258	42	to	to	TO
cord-017640-i8h48ny6	258	43	better	better	RB
cord-017640-i8h48ny6	258	44	understand	understand	VB
cord-017640-i8h48ny6	258	45	the	the	DT
cord-017640-i8h48ny6	258	46	molecular	molecular	JJ
cord-017640-i8h48ny6	258	47	mechanisms	mechanism	NNS
cord-017640-i8h48ny6	258	48	implemented	implement	VBN
cord-017640-i8h48ny6	258	49	by	by	IN
cord-017640-i8h48ny6	258	50	this	this	DT
cord-017640-i8h48ny6	258	51	ligand	ligand	NN
cord-017640-i8h48ny6	258	52	and	and	CC
cord-017640-i8h48ny6	258	53	thus	thus	RB
cord-017640-i8h48ny6	258	54	predict	predict	VB
cord-017640-i8h48ny6	258	55	its	-PRON-	PRP$
cord-017640-i8h48ny6	258	56	subsequent	subsequent	JJ
cord-017640-i8h48ny6	258	57	biological	biological	JJ
cord-017640-i8h48ny6	258	58	functions	function	NNS
cord-017640-i8h48ny6	258	59	.	.	.
cord-017640-i8h48ny6	259	1	Apoptosis	apoptosis	NN
cord-017640-i8h48ny6	259	2	is	be	VBZ
cord-017640-i8h48ny6	259	3	a	a	DT
cord-017640-i8h48ny6	259	4	fundamental	fundamental	JJ
cord-017640-i8h48ny6	259	5	process	process	NN
cord-017640-i8h48ny6	259	6	contributing	contribute	VBG
cord-017640-i8h48ny6	259	7	to	to	IN
cord-017640-i8h48ny6	259	8	tissue	tissue	NN
cord-017640-i8h48ny6	259	9	homeostasis	homeostasis	NN
cord-017640-i8h48ny6	259	10	,	,	,
cord-017640-i8h48ny6	259	11	immune	immune	JJ
cord-017640-i8h48ny6	259	12	response	response	NN
cord-017640-i8h48ny6	259	13	,	,	,
cord-017640-i8h48ny6	259	14	and	and	CC
cord-017640-i8h48ny6	259	15	development	development	NN
cord-017640-i8h48ny6	259	16	.	.	.
cord-017640-i8h48ny6	260	1	CD95	CD95	NNP
cord-017640-i8h48ny6	260	2	,	,	,
cord-017640-i8h48ny6	260	3	also	also	RB
cord-017640-i8h48ny6	260	4	called	call	VBN
cord-017640-i8h48ny6	260	5	Fas	Fas	NNP
cord-017640-i8h48ny6	260	6	,	,	,
cord-017640-i8h48ny6	260	7	is	be	VBZ
cord-017640-i8h48ny6	260	8	a	a	DT
cord-017640-i8h48ny6	260	9	member	member	NN
cord-017640-i8h48ny6	260	10	of	of	IN
cord-017640-i8h48ny6	260	11	the	the	DT
cord-017640-i8h48ny6	260	12	tumor	tumor	NN
cord-017640-i8h48ny6	260	13	necrosis	necrosis	NN
cord-017640-i8h48ny6	260	14	factor	factor	NN
cord-017640-i8h48ny6	260	15	receptor	receptor	NN
cord-017640-i8h48ny6	260	16	(	(	-LRB-
cord-017640-i8h48ny6	260	17	TNFR	TNFR	NNP
cord-017640-i8h48ny6	260	18	)	)	-RRB-
cord-017640-i8h48ny6	260	19	superfamily	superfamily	NN
cord-017640-i8h48ny6	260	20	.	.	.
cord-017640-i8h48ny6	261	1	Its	-PRON-	PRP$
cord-017640-i8h48ny6	261	2	ligand	ligand	NN
cord-017640-i8h48ny6	261	3	,	,	,
cord-017640-i8h48ny6	261	4	CD95L	cd95l	NN
cord-017640-i8h48ny6	261	5	,	,	,
cord-017640-i8h48ny6	261	6	was	be	VBD
cord-017640-i8h48ny6	261	7	initially	initially	RB
cord-017640-i8h48ny6	261	8	detected	detect	VBN
cord-017640-i8h48ny6	261	9	at	at	IN
cord-017640-i8h48ny6	261	10	the	the	DT
cord-017640-i8h48ny6	261	11	plasma	plasma	NN
cord-017640-i8h48ny6	261	12	membrane	membrane	NN
cord-017640-i8h48ny6	261	13	of	of	IN
cord-017640-i8h48ny6	261	14	activated	activate	VBN
cord-017640-i8h48ny6	261	15	T	t	NN
cord-017640-i8h48ny6	261	16	-	-	HYPH
cord-017640-i8h48ny6	261	17	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	261	18	and	and	CC
cord-017640-i8h48ny6	261	19	natural	natural	JJ
cord-017640-i8h48ny6	261	20	killer	killer	NN
cord-017640-i8h48ny6	261	21	(	(	-LRB-
cord-017640-i8h48ny6	261	22	NK	NK	NNP
cord-017640-i8h48ny6	261	23	)	)	-RRB-
cord-017640-i8h48ny6	261	24	cells	cell	NNS
cord-017640-i8h48ny6	261	25	where	where	WRB
cord-017640-i8h48ny6	261	26	it	-PRON-	PRP
cord-017640-i8h48ny6	261	27	contributes	contribute	VBZ
cord-017640-i8h48ny6	261	28	to	to	IN
cord-017640-i8h48ny6	261	29	the	the	DT
cord-017640-i8h48ny6	261	30	elimination	elimination	NN
cord-017640-i8h48ny6	261	31	of	of	IN
cord-017640-i8h48ny6	261	32	transformed	transform	VBN
cord-017640-i8h48ny6	261	33	and	and	CC
cord-017640-i8h48ny6	261	34	infected	infected	JJ
cord-017640-i8h48ny6	261	35	cells	cell	NNS
cord-017640-i8h48ny6	261	36	.	.	.
cord-017640-i8h48ny6	262	1	Given	give	VBN
cord-017640-i8h48ny6	262	2	its	-PRON-	PRP$
cord-017640-i8h48ny6	262	3	implication	implication	NN
cord-017640-i8h48ny6	262	4	in	in	IN
cord-017640-i8h48ny6	262	5	immune	immune	JJ
cord-017640-i8h48ny6	262	6	homeostasis	homeostasis	NN
cord-017640-i8h48ny6	262	7	and	and	CC
cord-017640-i8h48ny6	262	8	immune	immune	JJ
cord-017640-i8h48ny6	262	9	surveillance	surveillance	NN
cord-017640-i8h48ny6	262	10	combined	combine	VBN
cord-017640-i8h48ny6	262	11	with	with	IN
cord-017640-i8h48ny6	262	12	the	the	DT
cord-017640-i8h48ny6	262	13	fact	fact	NN
cord-017640-i8h48ny6	262	14	that	that	IN
cord-017640-i8h48ny6	262	15	various	various	JJ
cord-017640-i8h48ny6	262	16	lineages	lineage	NNS
cord-017640-i8h48ny6	262	17	of	of	IN
cord-017640-i8h48ny6	262	18	malignant	malignant	JJ
cord-017640-i8h48ny6	262	19	cells	cell	NNS
cord-017640-i8h48ny6	262	20	exhibit	exhibit	VBP
cord-017640-i8h48ny6	262	21	lossof	lossof	NN
cord-017640-i8h48ny6	262	22	-	-	HYPH
cord-017640-i8h48ny6	262	23	function	function	NN
cord-017640-i8h48ny6	262	24	mutations	mutation	NNS
cord-017640-i8h48ny6	262	25	,	,	,
cord-017640-i8h48ny6	262	26	CD95	CD95	NNP
cord-017640-i8h48ny6	262	27	was	be	VBD
cord-017640-i8h48ny6	262	28	initially	initially	RB
cord-017640-i8h48ny6	262	29	classified	classify	VBN
cord-017640-i8h48ny6	262	30	as	as	IN
cord-017640-i8h48ny6	262	31	a	a	DT
cord-017640-i8h48ny6	262	32	tumor	tumor	NN
cord-017640-i8h48ny6	262	33	suppressor	suppressor	NN
cord-017640-i8h48ny6	262	34	gene	gene	NN
cord-017640-i8h48ny6	262	35	.	.	.
cord-017640-i8h48ny6	263	1	Nonetheless	nonetheless	RB
cord-017640-i8h48ny6	263	2	,	,	,
cord-017640-i8h48ny6	263	3	in	in	IN
cord-017640-i8h48ny6	263	4	different	different	JJ
cord-017640-i8h48ny6	263	5	pathophysiological	pathophysiological	JJ
cord-017640-i8h48ny6	263	6	contexts	context	NNS
cord-017640-i8h48ny6	263	7	,	,	,
cord-017640-i8h48ny6	263	8	this	this	DT
cord-017640-i8h48ny6	263	9	receptor	receptor	NN
cord-017640-i8h48ny6	263	10	is	be	VBZ
cord-017640-i8h48ny6	263	11	able	able	JJ
cord-017640-i8h48ny6	263	12	to	to	TO
cord-017640-i8h48ny6	263	13	transmit	transmit	VB
cord-017640-i8h48ny6	263	14	non	non	JJ
cord-017640-i8h48ny6	263	15	-	-	JJ
cord-017640-i8h48ny6	263	16	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	263	17	signals	signal	NNS
cord-017640-i8h48ny6	263	18	and	and	CC
cord-017640-i8h48ny6	263	19	promote	promote	VB
cord-017640-i8h48ny6	263	20	inflammation	inflammation	NN
cord-017640-i8h48ny6	263	21	and	and	CC
cord-017640-i8h48ny6	263	22	carcinogenesis	carcinogenesis	NN
cord-017640-i8h48ny6	263	23	.	.	.
cord-017640-i8h48ny6	264	1	Although	although	IN
cord-017640-i8h48ny6	264	2	the	the	DT
cord-017640-i8h48ny6	264	3	different	different	JJ
cord-017640-i8h48ny6	264	4	non	non	JJ
cord-017640-i8h48ny6	264	5	-	-	JJ
cord-017640-i8h48ny6	264	6	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	264	7	signaling	signal	VBG
cord-017640-i8h48ny6	264	8	pathways	pathway	NNS
cord-017640-i8h48ny6	264	9	(	(	-LRB-
cord-017640-i8h48ny6	264	10	NF	nf	NN
cord-017640-i8h48ny6	264	11	-	-	HYPH
cord-017640-i8h48ny6	264	12	κB	κB	NNP
cord-017640-i8h48ny6	264	13	,	,	,
cord-017640-i8h48ny6	264	14	MAPK	MAPK	NNP
cord-017640-i8h48ny6	264	15	,	,	,
cord-017640-i8h48ny6	264	16	and	and	CC
cord-017640-i8h48ny6	264	17	PI3	PI3	NNP
cord-017640-i8h48ny6	264	18	K	K	NNP
cord-017640-i8h48ny6	264	19	)	)	-RRB-
cord-017640-i8h48ny6	264	20	triggered	trigger	VBN
cord-017640-i8h48ny6	264	21	by	by	IN
cord-017640-i8h48ny6	264	22	CD95	CD95	NNP
cord-017640-i8h48ny6	264	23	are	be	VBP
cord-017640-i8h48ny6	264	24	known	know	VBN
cord-017640-i8h48ny6	264	25	,	,	,
cord-017640-i8h48ny6	264	26	the	the	DT
cord-017640-i8h48ny6	264	27	initial	initial	JJ
cord-017640-i8h48ny6	264	28	molecular	molecular	JJ
cord-017640-i8h48ny6	264	29	events	event	NNS
cord-017640-i8h48ny6	264	30	leading	lead	VBG
cord-017640-i8h48ny6	264	31	to	to	IN
cord-017640-i8h48ny6	264	32	these	these	DT
cord-017640-i8h48ny6	264	33	signals	signal	NNS
cord-017640-i8h48ny6	264	34	,	,	,
cord-017640-i8h48ny6	264	35	the	the	DT
cord-017640-i8h48ny6	264	36	mechanisms	mechanism	NNS
cord-017640-i8h48ny6	264	37	by	by	IN
cord-017640-i8h48ny6	264	38	which	which	WDT
cord-017640-i8h48ny6	264	39	the	the	DT
cord-017640-i8h48ny6	264	40	receptor	receptor	NN
cord-017640-i8h48ny6	264	41	switches	switch	VBZ
cord-017640-i8h48ny6	264	42	from	from	IN
cord-017640-i8h48ny6	264	43	an	an	DT
cord-017640-i8h48ny6	264	44	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	264	45	function	function	NN
cord-017640-i8h48ny6	264	46	to	to	IN
cord-017640-i8h48ny6	264	47	an	an	DT
cord-017640-i8h48ny6	264	48	inflammatory	inflammatory	JJ
cord-017640-i8h48ny6	264	49	role	role	NN
cord-017640-i8h48ny6	264	50	,	,	,
cord-017640-i8h48ny6	264	51	and	and	CC
cord-017640-i8h48ny6	264	52	,	,	,
cord-017640-i8h48ny6	264	53	more	more	RBR
cord-017640-i8h48ny6	264	54	importantly	importantly	RB
cord-017640-i8h48ny6	264	55	,	,	,
cord-017640-i8h48ny6	264	56	the	the	DT
cord-017640-i8h48ny6	264	57	biological	biological	JJ
cord-017640-i8h48ny6	264	58	functions	function	NNS
cord-017640-i8h48ny6	264	59	of	of	IN
cord-017640-i8h48ny6	264	60	these	these	DT
cord-017640-i8h48ny6	264	61	signals	signal	NNS
cord-017640-i8h48ny6	264	62	remain	remain	VBP
cord-017640-i8h48ny6	264	63	elusive	elusive	JJ
cord-017640-i8h48ny6	264	64	.	.	.
cord-017640-i8h48ny6	265	1	Apoptosis	apoptosis	NN
cord-017640-i8h48ny6	265	2	:	:	:
cord-017640-i8h48ny6	265	3	a	a	DT
cord-017640-i8h48ny6	265	4	basic	basic	JJ
cord-017640-i8h48ny6	265	5	biological	biological	JJ
cord-017640-i8h48ny6	265	6	phenomenon	phenomenon	NN
cord-017640-i8h48ny6	265	7	with	with	IN
cord-017640-i8h48ny6	265	8	wide	wide	RB
cord-017640-i8h48ny6	265	9	-	-	HYPH
cord-017640-i8h48ny6	265	10	ranging	range	VBG
cord-017640-i8h48ny6	265	11	implications	implication	NNS
cord-017640-i8h48ny6	265	12	in	in	IN
cord-017640-i8h48ny6	265	13	tissue	tissue	NN
cord-017640-i8h48ny6	265	14	kinetics	kinetics	NNP
cord-017640-i8h48ny6	265	15	Induction	Induction	NNP
cord-017640-i8h48ny6	265	16	of	of	IN
cord-017640-i8h48ny6	265	17	TNF	TNF	NNP
cord-017640-i8h48ny6	265	18	receptor	receptor	NN
cord-017640-i8h48ny6	265	19	I	I	NNP
cord-017640-i8h48ny6	265	20	-	-	HYPH
cord-017640-i8h48ny6	265	21	mediated	mediate	VBN
cord-017640-i8h48ny6	265	22	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	265	23	via	via	IN
cord-017640-i8h48ny6	265	24	two	two	CD
cord-017640-i8h48ny6	265	25	sequential	sequential	JJ
cord-017640-i8h48ny6	265	26	signaling	signal	VBG
cord-017640-i8h48ny6	265	27	complexes	complex	NNS
cord-017640-i8h48ny6	265	28	Apoptosis	Apoptosis	NNP
cord-017640-i8h48ny6	265	29	in	in	IN
cord-017640-i8h48ny6	265	30	Alzheimer	Alzheimer	NNP
cord-017640-i8h48ny6	265	31	's	's	POS
cord-017640-i8h48ny6	265	32	diseasean	diseasean	JJ
cord-017640-i8h48ny6	265	33	update	update	NN
cord-017640-i8h48ny6	265	34	Apoptosis	Apoptosis	NNP
cord-017640-i8h48ny6	265	35	in	in	IN
cord-017640-i8h48ny6	265	36	Parkinson	Parkinson	NNP
cord-017640-i8h48ny6	265	37	's	's	POS
cord-017640-i8h48ny6	265	38	disease	disease	NN
cord-017640-i8h48ny6	265	39	:	:	:
cord-017640-i8h48ny6	265	40	signals	signal	NNS
cord-017640-i8h48ny6	265	41	for	for	IN
cord-017640-i8h48ny6	265	42	neuronal	neuronal	JJ
cord-017640-i8h48ny6	265	43	degradation	degradation	NN
cord-017640-i8h48ny6	266	1	Human	Human	NNP
cord-017640-i8h48ny6	266	2	ICE	ICE	NNP
cord-017640-i8h48ny6	266	3	/	/	SYM
cord-017640-i8h48ny6	266	4	CED-3	CED-3	NNP
cord-017640-i8h48ny6	266	5	protease	protease	NN
cord-017640-i8h48ny6	266	6	nomenclature	nomenclature	NN
cord-017640-i8h48ny6	267	1	The	the	DT
cord-017640-i8h48ny6	267	2	biochemistry	biochemistry	NN
cord-017640-i8h48ny6	267	3	of	of	IN
cord-017640-i8h48ny6	267	4	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	268	1	A	a	DT
cord-017640-i8h48ny6	268	2	novel	novel	JJ
cord-017640-i8h48ny6	268	3	protein	protein	NN
cord-017640-i8h48ny6	268	4	that	that	WDT
cord-017640-i8h48ny6	268	5	interacts	interact	VBZ
cord-017640-i8h48ny6	268	6	with	with	IN
cord-017640-i8h48ny6	268	7	the	the	DT
cord-017640-i8h48ny6	268	8	death	death	NN
cord-017640-i8h48ny6	268	9	domain	domain	NN
cord-017640-i8h48ny6	268	10	of	of	IN
cord-017640-i8h48ny6	268	11	Fas	Fas	NNP
cord-017640-i8h48ny6	268	12	/	/	SYM
cord-017640-i8h48ny6	268	13	APO1	APO1	NNP
cord-017640-i8h48ny6	268	14	contains	contain	VBZ
cord-017640-i8h48ny6	268	15	a	a	DT
cord-017640-i8h48ny6	268	16	sequence	sequence	NN
cord-017640-i8h48ny6	268	17	motif	motif	NN
cord-017640-i8h48ny6	268	18	related	relate	VBN
cord-017640-i8h48ny6	268	19	to	to	IN
cord-017640-i8h48ny6	268	20	the	the	DT
cord-017640-i8h48ny6	268	21	death	death	NN
cord-017640-i8h48ny6	268	22	domain	domain	NN
cord-017640-i8h48ny6	268	23	FADD	FADD	NNP
cord-017640-i8h48ny6	268	24	,	,	,
cord-017640-i8h48ny6	268	25	a	a	DT
cord-017640-i8h48ny6	268	26	novel	novel	JJ
cord-017640-i8h48ny6	268	27	death	death	NN
cord-017640-i8h48ny6	268	28	domain	domain	NN
cord-017640-i8h48ny6	268	29	-	-	HYPH
cord-017640-i8h48ny6	268	30	containing	contain	VBG
cord-017640-i8h48ny6	268	31	protein	protein	NN
cord-017640-i8h48ny6	268	32	,	,	,
cord-017640-i8h48ny6	268	33	interacts	interact	VBZ
cord-017640-i8h48ny6	268	34	with	with	IN
cord-017640-i8h48ny6	268	35	the	the	DT
cord-017640-i8h48ny6	268	36	death	death	NN
cord-017640-i8h48ny6	268	37	domain	domain	NN
cord-017640-i8h48ny6	268	38	of	of	IN
cord-017640-i8h48ny6	268	39	Fas	Fas	NNP
cord-017640-i8h48ny6	268	40	and	and	CC
cord-017640-i8h48ny6	268	41	initiates	initiate	VBZ
cord-017640-i8h48ny6	268	42	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	268	43	The	the	DT
cord-017640-i8h48ny6	268	44	TNF	TNF	NNP
cord-017640-i8h48ny6	268	45	receptor	receptor	NN
cord-017640-i8h48ny6	268	46	1-associated	1-associated	CD
cord-017640-i8h48ny6	268	47	protein	protein	NN
cord-017640-i8h48ny6	268	48	TRADD	TRADD	NNP
cord-017640-i8h48ny6	268	49	signals	signal	VBZ
cord-017640-i8h48ny6	268	50	cell	cell	NN
cord-017640-i8h48ny6	268	51	death	death	NN
cord-017640-i8h48ny6	268	52	and	and	CC
cord-017640-i8h48ny6	268	53	NF	nf	NN
cord-017640-i8h48ny6	268	54	-	-	HYPH
cord-017640-i8h48ny6	268	55	kappa	kappa	NN
cord-017640-i8h48ny6	268	56	B	B	NNP
cord-017640-i8h48ny6	268	57	activation	activation	NN
cord-017640-i8h48ny6	268	58	Cytotoxicity	Cytotoxicity	NNP
cord-017640-i8h48ny6	268	59	-	-	HYPH
cord-017640-i8h48ny6	268	60	dependent	dependent	JJ
cord-017640-i8h48ny6	268	61	APO-1	APO-1	NNP
cord-017640-i8h48ny6	269	1	(	(	-LRB-
cord-017640-i8h48ny6	269	2	Fas	Fas	NNP
cord-017640-i8h48ny6	269	3	/	/	SYM
cord-017640-i8h48ny6	269	4	CD95)-associated	CD95)-associated	NNP
cord-017640-i8h48ny6	269	5	proteins	protein	NNS
cord-017640-i8h48ny6	269	6	form	form	VBP
cord-017640-i8h48ny6	269	7	a	a	DT
cord-017640-i8h48ny6	269	8	deathinducing	deathinducing	NN
cord-017640-i8h48ny6	269	9	signaling	signal	VBG
cord-017640-i8h48ny6	269	10	complex	complex	NN
cord-017640-i8h48ny6	269	11	(	(	-LRB-
cord-017640-i8h48ny6	269	12	DISC	disc	NN
cord-017640-i8h48ny6	269	13	)	)	-RRB-
cord-017640-i8h48ny6	269	14	with	with	IN
cord-017640-i8h48ny6	269	15	the	the	DT
cord-017640-i8h48ny6	269	16	receptor	receptor	NN
cord-017640-i8h48ny6	269	17	Cytochrome	Cytochrome	NNP
cord-017640-i8h48ny6	269	18	c	c	NN
cord-017640-i8h48ny6	269	19	and	and	CC
cord-017640-i8h48ny6	269	20	dATP	datp	JJ
cord-017640-i8h48ny6	269	21	-	-	HYPH
cord-017640-i8h48ny6	269	22	dependent	dependent	JJ
cord-017640-i8h48ny6	269	23	formation	formation	NN
cord-017640-i8h48ny6	269	24	of	of	IN
cord-017640-i8h48ny6	269	25	Apaf-1	Apaf-1	NNP
cord-017640-i8h48ny6	269	26	/	/	SYM
cord-017640-i8h48ny6	269	27	caspase-9	caspase-9	NNP
cord-017640-i8h48ny6	269	28	complex	complex	NN
cord-017640-i8h48ny6	269	29	initiates	initiate	VBZ
cord-017640-i8h48ny6	269	30	an	an	DT
cord-017640-i8h48ny6	269	31	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	269	32	protease	protease	NN
cord-017640-i8h48ny6	269	33	cascade	cascade	VB
cord-017640-i8h48ny6	269	34	The	the	DT
cord-017640-i8h48ny6	269	35	polypeptide	polypeptide	NN
cord-017640-i8h48ny6	269	36	encoded	encode	VBN
cord-017640-i8h48ny6	269	37	by	by	IN
cord-017640-i8h48ny6	269	38	the	the	DT
cord-017640-i8h48ny6	269	39	cDNA	cdna	NN
cord-017640-i8h48ny6	269	40	for	for	IN
cord-017640-i8h48ny6	269	41	human	human	JJ
cord-017640-i8h48ny6	269	42	cell	cell	NN
cord-017640-i8h48ny6	269	43	surface	surface	NN
cord-017640-i8h48ny6	269	44	antigen	antigen	NN
cord-017640-i8h48ny6	269	45	Fas	Fas	NNP
cord-017640-i8h48ny6	269	46	can	can	MD
cord-017640-i8h48ny6	269	47	mediate	mediate	VB
cord-017640-i8h48ny6	269	48	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	269	49	Molecular	molecular	JJ
cord-017640-i8h48ny6	269	50	cloning	cloning	NN
cord-017640-i8h48ny6	269	51	and	and	CC
cord-017640-i8h48ny6	269	52	expression	expression	NN
cord-017640-i8h48ny6	269	53	of	of	IN
cord-017640-i8h48ny6	269	54	the	the	DT
cord-017640-i8h48ny6	269	55	human	human	JJ
cord-017640-i8h48ny6	269	56	55	55	CD
cord-017640-i8h48ny6	269	57	kd	kd	NNP
cord-017640-i8h48ny6	269	58	tumor	tumor	NN
cord-017640-i8h48ny6	269	59	necrosis	necrosis	NN
cord-017640-i8h48ny6	269	60	factor	factor	NN
cord-017640-i8h48ny6	269	61	receptor	receptor	NN
cord-017640-i8h48ny6	270	1	The	the	DT
cord-017640-i8h48ny6	270	2	receptor	receptor	NN
cord-017640-i8h48ny6	270	3	for	for	IN
cord-017640-i8h48ny6	270	4	the	the	DT
cord-017640-i8h48ny6	270	5	cytotoxic	cytotoxic	JJ
cord-017640-i8h48ny6	270	6	ligand	ligand	NN
cord-017640-i8h48ny6	270	7	TRAIL	TRAIL	NNP
cord-017640-i8h48ny6	270	8	TRAIL	TRAIL	NNP
cord-017640-i8h48ny6	270	9	-	-	HYPH
cord-017640-i8h48ny6	270	10	R2	R2	NNP
cord-017640-i8h48ny6	270	11	:	:	:
cord-017640-i8h48ny6	270	12	a	a	DT
cord-017640-i8h48ny6	270	13	novel	novel	JJ
cord-017640-i8h48ny6	270	14	apoptosismediating	apoptosismediating	NN
cord-017640-i8h48ny6	270	15	receptor	receptor	NN
cord-017640-i8h48ny6	270	16	for	for	IN
cord-017640-i8h48ny6	270	17	TRAIL	TRAIL	NNP
cord-017640-i8h48ny6	270	18	Identification	Identification	NNP
cord-017640-i8h48ny6	270	19	and	and	CC
cord-017640-i8h48ny6	270	20	functional	functional	JJ
cord-017640-i8h48ny6	270	21	characterization	characterization	NN
cord-017640-i8h48ny6	270	22	of	of	IN
cord-017640-i8h48ny6	270	23	DR6	DR6	NNP
cord-017640-i8h48ny6	270	24	,	,	,
cord-017640-i8h48ny6	270	25	a	a	DT
cord-017640-i8h48ny6	270	26	novel	novel	JJ
cord-017640-i8h48ny6	270	27	death	death	NN
cord-017640-i8h48ny6	270	28	domain	domain	NN
cord-017640-i8h48ny6	270	29	-	-	HYPH
cord-017640-i8h48ny6	270	30	containing	contain	VBG
cord-017640-i8h48ny6	270	31	TNF	TNF	NNP
cord-017640-i8h48ny6	270	32	receptor	receptor	NN
cord-017640-i8h48ny6	270	33	Fas	Fas	NNP
cord-017640-i8h48ny6	270	34	transduces	transduce	NNS
cord-017640-i8h48ny6	270	35	activation	activation	NN
cord-017640-i8h48ny6	270	36	signals	signal	NNS
cord-017640-i8h48ny6	270	37	in	in	IN
cord-017640-i8h48ny6	270	38	normal	normal	JJ
cord-017640-i8h48ny6	270	39	human	human	JJ
cord-017640-i8h48ny6	270	40	T	t	NN
cord-017640-i8h48ny6	270	41	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	271	1	Divergent	divergent	JJ
cord-017640-i8h48ny6	271	2	signalling	signal	VBG
cord-017640-i8h48ny6	271	3	via	via	IN
cord-017640-i8h48ny6	271	4	APO-1	APO-1	NNP
cord-017640-i8h48ny6	271	5	/	/	SYM
cord-017640-i8h48ny6	271	6	Fas	Fas	NNP
cord-017640-i8h48ny6	271	7	and	and	CC
cord-017640-i8h48ny6	271	8	the	the	DT
cord-017640-i8h48ny6	271	9	TNF	TNF	NNP
cord-017640-i8h48ny6	271	10	receptor	receptor	NN
cord-017640-i8h48ny6	271	11	,	,	,
cord-017640-i8h48ny6	271	12	two	two	CD
cord-017640-i8h48ny6	271	13	homologous	homologous	JJ
cord-017640-i8h48ny6	271	14	molecules	molecule	NNS
cord-017640-i8h48ny6	271	15	involved	involve	VBN
cord-017640-i8h48ny6	271	16	in	in	IN
cord-017640-i8h48ny6	271	17	physiological	physiological	JJ
cord-017640-i8h48ny6	271	18	cell	cell	NN
cord-017640-i8h48ny6	271	19	death	death	NN
cord-017640-i8h48ny6	272	1	The	the	DT
cord-017640-i8h48ny6	272	2	TNF	TNF	NNP
cord-017640-i8h48ny6	272	3	receptor	receptor	NN
cord-017640-i8h48ny6	272	4	superfamily	superfamily	NN
cord-017640-i8h48ny6	272	5	of	of	IN
cord-017640-i8h48ny6	272	6	cellular	cellular	JJ
cord-017640-i8h48ny6	272	7	and	and	CC
cord-017640-i8h48ny6	272	8	viral	viral	JJ
cord-017640-i8h48ny6	272	9	proteins	protein	NNS
cord-017640-i8h48ny6	272	10	:	:	:
cord-017640-i8h48ny6	272	11	activation	activation	NN
cord-017640-i8h48ny6	272	12	,	,	,
cord-017640-i8h48ny6	272	13	costimulation	costimulation	NN
cord-017640-i8h48ny6	272	14	,	,	,
cord-017640-i8h48ny6	272	15	and	and	CC
cord-017640-i8h48ny6	272	16	death	death	NN
cord-017640-i8h48ny6	273	1	The	the	DT
cord-017640-i8h48ny6	273	2	TNF	TNF	NNP
cord-017640-i8h48ny6	273	3	and	and	CC
cord-017640-i8h48ny6	273	4	TNF	TNF	NNP
cord-017640-i8h48ny6	273	5	receptor	receptor	NN
cord-017640-i8h48ny6	273	6	superfamilies	superfamily	NNS
cord-017640-i8h48ny6	273	7	:	:	:
cord-017640-i8h48ny6	273	8	integrating	integrate	VBG
cord-017640-i8h48ny6	273	9	mammalian	mammalian	JJ
cord-017640-i8h48ny6	273	10	biology	biology	NN
cord-017640-i8h48ny6	274	1	The	the	DT
cord-017640-i8h48ny6	274	2	molecular	molecular	JJ
cord-017640-i8h48ny6	274	3	architecture	architecture	NN
cord-017640-i8h48ny6	274	4	of	of	IN
cord-017640-i8h48ny6	274	5	the	the	DT
cord-017640-i8h48ny6	274	6	TNF	TNF	NNP
cord-017640-i8h48ny6	274	7	superfamily	superfamily	NN
cord-017640-i8h48ny6	274	8	Precise	precise	JJ
cord-017640-i8h48ny6	274	9	mapping	mapping	NN
cord-017640-i8h48ny6	274	10	of	of	IN
cord-017640-i8h48ny6	274	11	the	the	DT
cord-017640-i8h48ny6	274	12	CD95	CD95	NNP
cord-017640-i8h48ny6	274	13	pre	pre	JJ
cord-017640-i8h48ny6	274	14	-	-	JJ
cord-017640-i8h48ny6	274	15	ligand	ligand	JJ
cord-017640-i8h48ny6	274	16	assembly	assembly	NN
cord-017640-i8h48ny6	274	17	domain	domain	NN
cord-017640-i8h48ny6	274	18	Identification	identification	NN
cord-017640-i8h48ny6	274	19	and	and	CC
cord-017640-i8h48ny6	274	20	characterization	characterization	NN
cord-017640-i8h48ny6	274	21	of	of	IN
cord-017640-i8h48ny6	274	22	a	a	DT
cord-017640-i8h48ny6	274	23	ligand	ligand	NN
cord-017640-i8h48ny6	274	24	-	-	HYPH
cord-017640-i8h48ny6	274	25	independent	independent	JJ
cord-017640-i8h48ny6	274	26	oligomerization	oligomerization	NN
cord-017640-i8h48ny6	274	27	domain	domain	NN
cord-017640-i8h48ny6	274	28	in	in	IN
cord-017640-i8h48ny6	274	29	the	the	DT
cord-017640-i8h48ny6	274	30	extracellular	extracellular	JJ
cord-017640-i8h48ny6	274	31	region	region	NN
cord-017640-i8h48ny6	274	32	of	of	IN
cord-017640-i8h48ny6	274	33	the	the	DT
cord-017640-i8h48ny6	274	34	CD95	CD95	NNP
cord-017640-i8h48ny6	274	35	death	death	NN
cord-017640-i8h48ny6	274	36	receptor	receptor	NN
cord-017640-i8h48ny6	274	37	Fas	Fas	NNP
cord-017640-i8h48ny6	274	38	preassociation	preassociation	NN
cord-017640-i8h48ny6	274	39	required	require	VBN
cord-017640-i8h48ny6	274	40	for	for	IN
cord-017640-i8h48ny6	274	41	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	274	42	signaling	signal	VBG
cord-017640-i8h48ny6	274	43	and	and	CC
cord-017640-i8h48ny6	274	44	dominant	dominant	JJ
cord-017640-i8h48ny6	274	45	inhibition	inhibition	NN
cord-017640-i8h48ny6	274	46	by	by	IN
cord-017640-i8h48ny6	274	47	pathogenic	pathogenic	JJ
cord-017640-i8h48ny6	274	48	mutations	mutation	NNS
cord-017640-i8h48ny6	275	1	A	a	DT
cord-017640-i8h48ny6	275	2	novel	novel	JJ
cord-017640-i8h48ny6	275	3	protein	protein	NN
cord-017640-i8h48ny6	275	4	domain	domain	NN
cord-017640-i8h48ny6	275	5	required	require	VBN
cord-017640-i8h48ny6	275	6	for	for	IN
cord-017640-i8h48ny6	275	7	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	275	8	.	.	.
cord-017640-i8h48ny6	276	1	Mutational	mutational	JJ
cord-017640-i8h48ny6	276	2	analysis	analysis	NN
cord-017640-i8h48ny6	276	3	of	of	IN
cord-017640-i8h48ny6	276	4	human	human	JJ
cord-017640-i8h48ny6	276	5	Fas	Fas	NNP
cord-017640-i8h48ny6	276	6	antigen	antigen	NN
cord-017640-i8h48ny6	276	7	A	a	DT
cord-017640-i8h48ny6	276	8	novel	novel	JJ
cord-017640-i8h48ny6	276	9	domain	domain	NN
cord-017640-i8h48ny6	276	10	within	within	IN
cord-017640-i8h48ny6	276	11	the	the	DT
cord-017640-i8h48ny6	276	12	55	55	CD
cord-017640-i8h48ny6	276	13	kd	kd	NNP
cord-017640-i8h48ny6	276	14	TNF	TNF	NNP
cord-017640-i8h48ny6	276	15	receptor	receptor	NN
cord-017640-i8h48ny6	276	16	signals	signal	VBZ
cord-017640-i8h48ny6	276	17	cell	cell	NN
cord-017640-i8h48ny6	276	18	death	death	NN
cord-017640-i8h48ny6	277	1	The	the	DT
cord-017640-i8h48ny6	277	2	growth	growth	NN
cord-017640-i8h48ny6	277	3	factor	factor	NN
cord-017640-i8h48ny6	277	4	progranulin	progranulin	NNP
cord-017640-i8h48ny6	277	5	binds	bind	VBZ
cord-017640-i8h48ny6	277	6	to	to	IN
cord-017640-i8h48ny6	277	7	TNF	TNF	NNP
cord-017640-i8h48ny6	277	8	receptors	receptor	NNS
cord-017640-i8h48ny6	277	9	and	and	CC
cord-017640-i8h48ny6	277	10	is	be	VBZ
cord-017640-i8h48ny6	277	11	therapeutic	therapeutic	JJ
cord-017640-i8h48ny6	277	12	against	against	IN
cord-017640-i8h48ny6	277	13	inflammatory	inflammatory	JJ
cord-017640-i8h48ny6	277	14	arthritis	arthritis	NN
cord-017640-i8h48ny6	277	15	in	in	IN
cord-017640-i8h48ny6	277	16	mice	mouse	NNS
cord-017640-i8h48ny6	277	17	Signal	Signal	NNP
cord-017640-i8h48ny6	277	18	transduction	transduction	NN
cord-017640-i8h48ny6	277	19	by	by	IN
cord-017640-i8h48ny6	277	20	tumor	tumor	NN
cord-017640-i8h48ny6	277	21	necrosis	necrosis	NN
cord-017640-i8h48ny6	277	22	factor	factor	NN
cord-017640-i8h48ny6	278	1	receptors	receptor	NNS
cord-017640-i8h48ny6	278	2	A	a	DT
cord-017640-i8h48ny6	278	3	domain	domain	NN
cord-017640-i8h48ny6	278	4	in	in	IN
cord-017640-i8h48ny6	278	5	TNF	TNF	NNP
cord-017640-i8h48ny6	278	6	receptors	receptor	NNS
cord-017640-i8h48ny6	278	7	that	that	WDT
cord-017640-i8h48ny6	278	8	mediates	mediate	VBZ
cord-017640-i8h48ny6	278	9	ligand	ligand	NN
cord-017640-i8h48ny6	278	10	-	-	HYPH
cord-017640-i8h48ny6	278	11	independent	independent	JJ
cord-017640-i8h48ny6	278	12	receptor	receptor	NN
cord-017640-i8h48ny6	278	13	assembly	assembly	NN
cord-017640-i8h48ny6	278	14	and	and	CC
cord-017640-i8h48ny6	278	15	signaling	signal	VBG
cord-017640-i8h48ny6	278	16	Human	human	JJ
cord-017640-i8h48ny6	278	17	tumour	tumour	NN
cord-017640-i8h48ny6	278	18	necrosis	necrosis	NN
cord-017640-i8h48ny6	278	19	factor	factor	NN
cord-017640-i8h48ny6	278	20	:	:	:
cord-017640-i8h48ny6	278	21	precursor	precursor	NN
cord-017640-i8h48ny6	278	22	structure	structure	NN
cord-017640-i8h48ny6	278	23	,	,	,
cord-017640-i8h48ny6	278	24	expression	expression	NN
cord-017640-i8h48ny6	278	25	and	and	CC
cord-017640-i8h48ny6	278	26	homology	homology	NN
cord-017640-i8h48ny6	278	27	to	to	TO
cord-017640-i8h48ny6	278	28	lymphotoxin	lymphotoxin	VB
cord-017640-i8h48ny6	278	29	A	a	DT
cord-017640-i8h48ny6	278	30	metalloproteinase	metalloproteinase	NN
cord-017640-i8h48ny6	278	31	disintegrin	disintegrin	NN
cord-017640-i8h48ny6	278	32	that	that	WDT
cord-017640-i8h48ny6	278	33	releases	release	VBZ
cord-017640-i8h48ny6	278	34	tumour	tumour	NN
cord-017640-i8h48ny6	278	35	-	-	HYPH
cord-017640-i8h48ny6	278	36	necrosis	necrosis	NN
cord-017640-i8h48ny6	278	37	factor	factor	NN
cord-017640-i8h48ny6	278	38	-	-	HYPH
cord-017640-i8h48ny6	278	39	alpha	alpha	NN
cord-017640-i8h48ny6	278	40	from	from	IN
cord-017640-i8h48ny6	278	41	cells	cell	NNS
cord-017640-i8h48ny6	278	42	Cloning	clone	VBG
cord-017640-i8h48ny6	278	43	of	of	IN
cord-017640-i8h48ny6	278	44	a	a	DT
cord-017640-i8h48ny6	278	45	disintegrin	disintegrin	JJ
cord-017640-i8h48ny6	278	46	metalloproteinase	metalloproteinase	NN
cord-017640-i8h48ny6	278	47	that	that	WDT
cord-017640-i8h48ny6	278	48	processes	process	VBZ
cord-017640-i8h48ny6	278	49	precursor	precursor	NN
cord-017640-i8h48ny6	278	50	tumour	tumour	NN
cord-017640-i8h48ny6	278	51	-	-	HYPH
cord-017640-i8h48ny6	278	52	necrosis	necrosis	NN
cord-017640-i8h48ny6	278	53	factor	factor	NN
cord-017640-i8h48ny6	278	54	-	-	HYPH
cord-017640-i8h48ny6	278	55	alpha	alpha	NN
cord-017640-i8h48ny6	278	56	The	the	DT
cord-017640-i8h48ny6	278	57	transmembrane	transmembrane	JJ
cord-017640-i8h48ny6	278	58	form	form	NN
cord-017640-i8h48ny6	278	59	of	of	IN
cord-017640-i8h48ny6	278	60	tumor	tumor	NN
cord-017640-i8h48ny6	278	61	necrosis	necrosis	NN
cord-017640-i8h48ny6	278	62	factor	factor	NN
cord-017640-i8h48ny6	278	63	is	be	VBZ
cord-017640-i8h48ny6	278	64	the	the	DT
cord-017640-i8h48ny6	278	65	prime	prime	JJ
cord-017640-i8h48ny6	278	66	activating	activate	VBG
cord-017640-i8h48ny6	278	67	ligand	ligand	NN
cord-017640-i8h48ny6	278	68	of	of	IN
cord-017640-i8h48ny6	278	69	the	the	DT
cord-017640-i8h48ny6	278	70	80	80	CD
cord-017640-i8h48ny6	278	71	kDa	kDa	NNP
cord-017640-i8h48ny6	278	72	tumor	tumor	NN
cord-017640-i8h48ny6	278	73	necrosis	necrosis	NN
cord-017640-i8h48ny6	278	74	factor	factor	NN
cord-017640-i8h48ny6	278	75	receptor	receptor	NN
cord-017640-i8h48ny6	278	76	NF	NF	NNP
cord-017640-i8h48ny6	278	77	-	-	HYPH
cord-017640-i8h48ny6	278	78	kappaB	kappaB	NNP
cord-017640-i8h48ny6	278	79	antiapoptosis	antiapoptosis	NN
cord-017640-i8h48ny6	278	80	:	:	:
cord-017640-i8h48ny6	278	81	induction	induction	NN
cord-017640-i8h48ny6	278	82	of	of	IN
cord-017640-i8h48ny6	278	83	TRAF1	TRAF1	NNP
cord-017640-i8h48ny6	279	1	and	and	CC
cord-017640-i8h48ny6	279	2	TRAF2	TRAF2	NNP
cord-017640-i8h48ny6	279	3	and	and	CC
cord-017640-i8h48ny6	279	4	c	c	NN
cord-017640-i8h48ny6	279	5	-	-	:
cord-017640-i8h48ny6	279	6	IAP1	IAP1	NNP
cord-017640-i8h48ny6	279	7	and	and	CC
cord-017640-i8h48ny6	279	8	c	c	NN
cord-017640-i8h48ny6	279	9	-	-	:
cord-017640-i8h48ny6	279	10	IAP2	IAP2	NNP
cord-017640-i8h48ny6	280	1	to	to	TO
cord-017640-i8h48ny6	280	2	suppress	suppress	VB
cord-017640-i8h48ny6	280	3	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	280	4	activation	activation	NN
cord-017640-i8h48ny6	280	5	Recruitment	Recruitment	NNP
cord-017640-i8h48ny6	280	6	of	of	IN
cord-017640-i8h48ny6	280	7	the	the	DT
cord-017640-i8h48ny6	280	8	linear	linear	JJ
cord-017640-i8h48ny6	280	9	ubiquitin	ubiquitin	NN
cord-017640-i8h48ny6	280	10	chain	chain	NN
cord-017640-i8h48ny6	280	11	assembly	assembly	NN
cord-017640-i8h48ny6	280	12	complex	complex	NN
cord-017640-i8h48ny6	280	13	stabilizes	stabilize	VBZ
cord-017640-i8h48ny6	280	14	the	the	DT
cord-017640-i8h48ny6	280	15	TNF	TNF	NNP
cord-017640-i8h48ny6	280	16	-	-	HYPH
cord-017640-i8h48ny6	280	17	R1	R1	NNP
cord-017640-i8h48ny6	280	18	signaling	signal	VBG
cord-017640-i8h48ny6	280	19	complex	complex	NN
cord-017640-i8h48ny6	280	20	and	and	CC
cord-017640-i8h48ny6	280	21	is	be	VBZ
cord-017640-i8h48ny6	280	22	required	require	VBN
cord-017640-i8h48ny6	280	23	for	for	IN
cord-017640-i8h48ny6	280	24	TNF	TNF	NNP
cord-017640-i8h48ny6	280	25	-	-	HYPH
cord-017640-i8h48ny6	280	26	mediated	mediate	VBN
cord-017640-i8h48ny6	280	27	gene	gene	NN
cord-017640-i8h48ny6	280	28	induction	induction	NN
cord-017640-i8h48ny6	280	29	A	a	DT
cord-017640-i8h48ny6	280	30	ubiquitin	ubiquitin	NN
cord-017640-i8h48ny6	280	31	ligase	ligase	NN
cord-017640-i8h48ny6	280	32	complex	complex	NN
cord-017640-i8h48ny6	280	33	assembles	assemble	VBZ
cord-017640-i8h48ny6	280	34	linear	linear	JJ
cord-017640-i8h48ny6	280	35	polyubiquitin	polyubiquitin	NNS
cord-017640-i8h48ny6	280	36	chains	chain	NNS
cord-017640-i8h48ny6	281	1	Linear	linear	JJ
cord-017640-i8h48ny6	281	2	ubiquitination	ubiquitination	NN
cord-017640-i8h48ny6	281	3	prevents	prevent	VBZ
cord-017640-i8h48ny6	281	4	inflammation	inflammation	NN
cord-017640-i8h48ny6	281	5	and	and	CC
cord-017640-i8h48ny6	281	6	regulates	regulate	VBZ
cord-017640-i8h48ny6	281	7	immune	immune	JJ
cord-017640-i8h48ny6	281	8	signalling	signal	VBG
cord-017640-i8h48ny6	281	9	Rapid	rapid	JJ
cord-017640-i8h48ny6	281	10	turnover	turnover	NN
cord-017640-i8h48ny6	281	11	of	of	IN
cord-017640-i8h48ny6	281	12	c	c	NN
cord-017640-i8h48ny6	281	13	-	-	HYPH
cord-017640-i8h48ny6	281	14	FLIPshort	FLIPshort	NNP
cord-017640-i8h48ny6	281	15	is	be	VBZ
cord-017640-i8h48ny6	281	16	determined	determine	VBN
cord-017640-i8h48ny6	281	17	by	by	IN
cord-017640-i8h48ny6	281	18	its	-PRON-	PRP$
cord-017640-i8h48ny6	281	19	unique	unique	JJ
cord-017640-i8h48ny6	281	20	C	c	NN
cord-017640-i8h48ny6	281	21	-	-	HYPH
cord-017640-i8h48ny6	281	22	terminal	terminal	NN
cord-017640-i8h48ny6	281	23	tail	tail	NN
cord-017640-i8h48ny6	281	24	NF	nf	NN
cord-017640-i8h48ny6	281	25	-	-	HYPH
cord-017640-i8h48ny6	281	26	kappaB	kappaB	NNP
cord-017640-i8h48ny6	281	27	suppression	suppression	NN
cord-017640-i8h48ny6	281	28	by	by	IN
cord-017640-i8h48ny6	281	29	the	the	DT
cord-017640-i8h48ny6	281	30	deubiquitinating	deubiquitinating	NN
cord-017640-i8h48ny6	281	31	enzyme	enzyme	NN
cord-017640-i8h48ny6	281	32	Cezanne	Cezanne	NNP
cord-017640-i8h48ny6	281	33	:	:	:
cord-017640-i8h48ny6	281	34	a	a	DT
cord-017640-i8h48ny6	281	35	novel	novel	JJ
cord-017640-i8h48ny6	281	36	negative	negative	JJ
cord-017640-i8h48ny6	281	37	feedback	feedback	NN
cord-017640-i8h48ny6	281	38	loop	loop	NN
cord-017640-i8h48ny6	281	39	in	in	IN
cord-017640-i8h48ny6	281	40	pro	pro	JJ
cord-017640-i8h48ny6	281	41	-	-	JJ
cord-017640-i8h48ny6	281	42	inflammatory	inflammatory	JJ
cord-017640-i8h48ny6	281	43	signaling	signal	VBG
cord-017640-i8h48ny6	281	44	RIPK	ripk	NN
cord-017640-i8h48ny6	281	45	-	-	HYPH
cord-017640-i8h48ny6	281	46	dependent	dependent	JJ
cord-017640-i8h48ny6	281	47	necrosis	necrosis	NN
cord-017640-i8h48ny6	281	48	and	and	CC
cord-017640-i8h48ny6	281	49	its	-PRON-	PRP$
cord-017640-i8h48ny6	281	50	regulation	regulation	NN
cord-017640-i8h48ny6	281	51	by	by	IN
cord-017640-i8h48ny6	281	52	caspases	caspase	NNS
cord-017640-i8h48ny6	281	53	:	:	:
cord-017640-i8h48ny6	281	54	a	a	DT
cord-017640-i8h48ny6	281	55	mystery	mystery	NN
cord-017640-i8h48ny6	281	56	in	in	IN
cord-017640-i8h48ny6	281	57	five	five	CD
cord-017640-i8h48ny6	281	58	acts	act	NNS
cord-017640-i8h48ny6	282	1	Fas	Fas	NNP
cord-017640-i8h48ny6	282	2	triggers	trigger	VBZ
cord-017640-i8h48ny6	282	3	an	an	DT
cord-017640-i8h48ny6	282	4	alternative	alternative	NN
cord-017640-i8h48ny6	282	5	,	,	,
cord-017640-i8h48ny6	282	6	caspase-8-independent	caspase-8-independent	NNP
cord-017640-i8h48ny6	282	7	cell	cell	NN
cord-017640-i8h48ny6	282	8	death	death	NN
cord-017640-i8h48ny6	282	9	pathway	pathway	NN
cord-017640-i8h48ny6	282	10	using	use	VBG
cord-017640-i8h48ny6	282	11	the	the	DT
cord-017640-i8h48ny6	282	12	kinase	kinase	NN
cord-017640-i8h48ny6	282	13	RIP	rip	NN
cord-017640-i8h48ny6	282	14	as	as	IN
cord-017640-i8h48ny6	282	15	effector	effector	NN
cord-017640-i8h48ny6	282	16	molecule	molecule	NN
cord-017640-i8h48ny6	282	17	Inhibition	inhibition	NN
cord-017640-i8h48ny6	282	18	of	of	IN
cord-017640-i8h48ny6	282	19	caspases	caspase	NNS
cord-017640-i8h48ny6	282	20	increases	increase	VBZ
cord-017640-i8h48ny6	282	21	the	the	DT
cord-017640-i8h48ny6	282	22	sensitivity	sensitivity	NN
cord-017640-i8h48ny6	282	23	of	of	IN
cord-017640-i8h48ny6	282	24	L929	l929	JJ
cord-017640-i8h48ny6	282	25	cells	cell	NNS
cord-017640-i8h48ny6	282	26	to	to	IN
cord-017640-i8h48ny6	282	27	necrosis	necrosis	NN
cord-017640-i8h48ny6	282	28	mediated	mediate	VBN
cord-017640-i8h48ny6	282	29	by	by	IN
cord-017640-i8h48ny6	282	30	tumor	tumor	NN
cord-017640-i8h48ny6	282	31	necrosis	necrosis	NN
cord-017640-i8h48ny6	282	32	factor	factor	NN
cord-017640-i8h48ny6	282	33	Phosphorylation	Phosphorylation	NNP
cord-017640-i8h48ny6	282	34	-	-	HYPH
cord-017640-i8h48ny6	282	35	driven	drive	VBN
cord-017640-i8h48ny6	282	36	assembly	assembly	NN
cord-017640-i8h48ny6	282	37	of	of	IN
cord-017640-i8h48ny6	282	38	the	the	DT
cord-017640-i8h48ny6	282	39	RIP1-RIP3	RIP1-RIP3	NNP
cord-017640-i8h48ny6	282	40	complex	complex	NN
cord-017640-i8h48ny6	282	41	regulates	regulate	VBZ
cord-017640-i8h48ny6	282	42	programmed	program	VBN
cord-017640-i8h48ny6	282	43	necrosis	necrosis	NN
cord-017640-i8h48ny6	282	44	and	and	CC
cord-017640-i8h48ny6	282	45	virus	virus	NN
cord-017640-i8h48ny6	282	46	-	-	HYPH
cord-017640-i8h48ny6	282	47	induced	induce	VBN
cord-017640-i8h48ny6	282	48	inflammation	inflammation	NN
cord-017640-i8h48ny6	283	1	RIP3	RIP3	NNP
cord-017640-i8h48ny6	283	2	mediates	mediate	VBZ
cord-017640-i8h48ny6	283	3	the	the	DT
cord-017640-i8h48ny6	283	4	embryonic	embryonic	JJ
cord-017640-i8h48ny6	283	5	lethality	lethality	NN
cord-017640-i8h48ny6	283	6	of	of	IN
cord-017640-i8h48ny6	283	7	caspase-8-deficient	caspase-8-deficient	NN
cord-017640-i8h48ny6	283	8	mice	mouse	NNS
cord-017640-i8h48ny6	283	9	Catalytic	catalytic	JJ
cord-017640-i8h48ny6	283	10	activity	activity	NN
cord-017640-i8h48ny6	283	11	of	of	IN
cord-017640-i8h48ny6	283	12	the	the	DT
cord-017640-i8h48ny6	283	13	caspase-8-FLIP(L	caspase-8-flip(l	NN
cord-017640-i8h48ny6	283	14	)	)	-RRB-
cord-017640-i8h48ny6	283	15	complex	complex	JJ
cord-017640-i8h48ny6	284	1	inhibits	inhibit	VBZ
cord-017640-i8h48ny6	284	2	RIPK3-dependent	RIPK3-dependent	:
cord-017640-i8h48ny6	284	3	necrosis	necrosis	NN
cord-017640-i8h48ny6	284	4	FADD	FADD	NNP
cord-017640-i8h48ny6	284	5	prevents	prevent	VBZ
cord-017640-i8h48ny6	284	6	RIP3-mediated	rip3-mediate	VBN
cord-017640-i8h48ny6	284	7	epithelial	epithelial	JJ
cord-017640-i8h48ny6	284	8	cell	cell	NN
cord-017640-i8h48ny6	284	9	necrosis	necrosis	NN
cord-017640-i8h48ny6	284	10	and	and	CC
cord-017640-i8h48ny6	284	11	chronic	chronic	JJ
cord-017640-i8h48ny6	284	12	intestinal	intestinal	JJ
cord-017640-i8h48ny6	284	13	inflammation	inflammation	NN
cord-017640-i8h48ny6	284	14	Lasker	Lasker	NNP
cord-017640-i8h48ny6	284	15	clinical	clinical	JJ
cord-017640-i8h48ny6	284	16	medical	medical	JJ
cord-017640-i8h48ny6	284	17	research	research	NN
cord-017640-i8h48ny6	284	18	award	award	NN
cord-017640-i8h48ny6	284	19	TNF	TNF	NNP
cord-017640-i8h48ny6	284	20	defined	define	VBD
cord-017640-i8h48ny6	284	21	as	as	IN
cord-017640-i8h48ny6	284	22	a	a	DT
cord-017640-i8h48ny6	284	23	therapeutic	therapeutic	JJ
cord-017640-i8h48ny6	284	24	target	target	NN
cord-017640-i8h48ny6	284	25	for	for	IN
cord-017640-i8h48ny6	284	26	rheumatoid	rheumatoid	NN
cord-017640-i8h48ny6	284	27	arthritis	arthritis	NN
cord-017640-i8h48ny6	284	28	and	and	CC
cord-017640-i8h48ny6	284	29	other	other	JJ
cord-017640-i8h48ny6	284	30	autoimmune	autoimmune	JJ
cord-017640-i8h48ny6	284	31	diseases	disease	NNS
cord-017640-i8h48ny6	285	1	Fas	Fas	NNP
cord-017640-i8h48ny6	285	2	engagement	engagement	NN
cord-017640-i8h48ny6	285	3	induces	induce	VBZ
cord-017640-i8h48ny6	285	4	neurite	neurite	NN
cord-017640-i8h48ny6	285	5	growth	growth	NN
cord-017640-i8h48ny6	285	6	through	through	IN
cord-017640-i8h48ny6	285	7	ERK	ERK	NNP
cord-017640-i8h48ny6	285	8	activation	activation	NN
cord-017640-i8h48ny6	285	9	and	and	CC
cord-017640-i8h48ny6	286	1	p35	p35	CD
cord-017640-i8h48ny6	286	2	upregulation	upregulation	NN
cord-017640-i8h48ny6	286	3	Fas	Fas	NNP
cord-017640-i8h48ny6	286	4	engagement	engagement	NN
cord-017640-i8h48ny6	286	5	accelerates	accelerate	VBZ
cord-017640-i8h48ny6	286	6	liver	liver	NN
cord-017640-i8h48ny6	286	7	regeneration	regeneration	NN
cord-017640-i8h48ny6	286	8	after	after	IN
cord-017640-i8h48ny6	286	9	partial	partial	JJ
cord-017640-i8h48ny6	286	10	hepatectomy	hepatectomy	NN
cord-017640-i8h48ny6	286	11	CD95-ligand	cd95-ligand	CD
cord-017640-i8h48ny6	286	12	on	on	IN
cord-017640-i8h48ny6	286	13	peripheral	peripheral	JJ
cord-017640-i8h48ny6	286	14	myeloid	myeloid	NN
cord-017640-i8h48ny6	286	15	cells	cell	NNS
cord-017640-i8h48ny6	286	16	activates	activate	VBZ
cord-017640-i8h48ny6	286	17	Syk	Syk	NNP
cord-017640-i8h48ny6	286	18	kinase	kinase	NN
cord-017640-i8h48ny6	286	19	to	to	TO
cord-017640-i8h48ny6	286	20	trigger	trigger	VB
cord-017640-i8h48ny6	286	21	their	-PRON-	PRP$
cord-017640-i8h48ny6	286	22	recruitment	recruitment	NN
cord-017640-i8h48ny6	286	23	to	to	IN
cord-017640-i8h48ny6	286	24	the	the	DT
cord-017640-i8h48ny6	286	25	inflammatory	inflammatory	JJ
cord-017640-i8h48ny6	286	26	site	site	NN
cord-017640-i8h48ny6	286	27	Membrane	membrane	NN
cord-017640-i8h48ny6	286	28	-	-	HYPH
cord-017640-i8h48ny6	286	29	bound	bind	VBN
cord-017640-i8h48ny6	286	30	Fas	Fas	NNP
cord-017640-i8h48ny6	286	31	ligand	ligand	NN
cord-017640-i8h48ny6	287	1	only	only	RB
cord-017640-i8h48ny6	287	2	is	be	VBZ
cord-017640-i8h48ny6	287	3	essential	essential	JJ
cord-017640-i8h48ny6	287	4	for	for	IN
cord-017640-i8h48ny6	288	1	Fas	Fas	NNP
cord-017640-i8h48ny6	288	2	-	-	HYPH
cord-017640-i8h48ny6	288	3	induced	induce	VBN
cord-017640-i8h48ny6	288	4	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	289	1	A	a	DT
cord-017640-i8h48ny6	289	2	novel	novel	JJ
cord-017640-i8h48ny6	289	3	juxtamembrane	juxtamembrane	NNP
cord-017640-i8h48ny6	289	4	domain	domain	NN
cord-017640-i8h48ny6	289	5	in	in	IN
cord-017640-i8h48ny6	289	6	tumor	tumor	NN
cord-017640-i8h48ny6	289	7	necrosis	necrosis	NN
cord-017640-i8h48ny6	289	8	factor	factor	NN
cord-017640-i8h48ny6	289	9	receptor	receptor	NN
cord-017640-i8h48ny6	289	10	superfamily	superfamily	NN
cord-017640-i8h48ny6	289	11	molecules	molecule	NNS
cord-017640-i8h48ny6	289	12	activates	activate	VBZ
cord-017640-i8h48ny6	289	13	Rac1	Rac1	NNP
cord-017640-i8h48ny6	289	14	and	and	CC
cord-017640-i8h48ny6	289	15	controls	control	NNS
cord-017640-i8h48ny6	289	16	neurite	neurite	NN
cord-017640-i8h48ny6	289	17	growth	growth	NN
cord-017640-i8h48ny6	290	1	The	the	DT
cord-017640-i8h48ny6	290	2	naturally	naturally	RB
cord-017640-i8h48ny6	290	3	processed	process	VBN
cord-017640-i8h48ny6	290	4	CD95L	cd95l	NN
cord-017640-i8h48ny6	290	5	elicits	elicit	VBZ
cord-017640-i8h48ny6	290	6	a	a	DT
cord-017640-i8h48ny6	290	7	c	c	NN
cord-017640-i8h48ny6	290	8	-	-	:
cord-017640-i8h48ny6	290	9	yes	yes	UH
cord-017640-i8h48ny6	290	10	/	/	SYM
cord-017640-i8h48ny6	290	11	calcium	calcium	NN
cord-017640-i8h48ny6	290	12	/	/	SYM
cord-017640-i8h48ny6	290	13	PI3K	PI3K	NNP
cord-017640-i8h48ny6	290	14	-	-	HYPH
cord-017640-i8h48ny6	290	15	driven	drive	VBN
cord-017640-i8h48ny6	290	16	cell	cell	NN
cord-017640-i8h48ny6	290	17	migration	migration	NN
cord-017640-i8h48ny6	290	18	pathway	pathway	NN
cord-017640-i8h48ny6	290	19	CD95-mediated	cd95-mediated	CD
cord-017640-i8h48ny6	290	20	cell	cell	NN
cord-017640-i8h48ny6	290	21	signaling	signal	VBG
cord-017640-i8h48ny6	290	22	in	in	IN
cord-017640-i8h48ny6	290	23	cancer	cancer	NN
cord-017640-i8h48ny6	290	24	:	:	:
cord-017640-i8h48ny6	291	1	mutations	mutation	NNS
cord-017640-i8h48ny6	291	2	and	and	CC
cord-017640-i8h48ny6	291	3	post	post	JJ
cord-017640-i8h48ny6	291	4	-	-	JJ
cord-017640-i8h48ny6	291	5	translational	translational	JJ
cord-017640-i8h48ny6	291	6	modulations	modulation	NNS
cord-017640-i8h48ny6	292	1	Monoclonal	monoclonal	JJ
cord-017640-i8h48ny6	292	2	antibody	antibody	NN
cord-017640-i8h48ny6	292	3	-	-	HYPH
cord-017640-i8h48ny6	292	4	mediated	mediate	VBN
cord-017640-i8h48ny6	292	5	tumor	tumor	NN
cord-017640-i8h48ny6	292	6	regression	regression	NN
cord-017640-i8h48ny6	292	7	by	by	IN
cord-017640-i8h48ny6	292	8	induction	induction	NN
cord-017640-i8h48ny6	292	9	of	of	IN
cord-017640-i8h48ny6	292	10	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	292	11	Molecular	molecular	JJ
cord-017640-i8h48ny6	292	12	cloning	cloning	NN
cord-017640-i8h48ny6	292	13	and	and	CC
cord-017640-i8h48ny6	292	14	expression	expression	NN
cord-017640-i8h48ny6	292	15	of	of	IN
cord-017640-i8h48ny6	292	16	the	the	DT
cord-017640-i8h48ny6	292	17	Fas	Fas	NNP
cord-017640-i8h48ny6	292	18	ligand	ligand	NN
cord-017640-i8h48ny6	292	19	,	,	,
cord-017640-i8h48ny6	292	20	a	a	DT
cord-017640-i8h48ny6	292	21	novel	novel	JJ
cord-017640-i8h48ny6	292	22	member	member	NN
cord-017640-i8h48ny6	292	23	of	of	IN
cord-017640-i8h48ny6	292	24	the	the	DT
cord-017640-i8h48ny6	292	25	tumor	tumor	NN
cord-017640-i8h48ny6	292	26	necrosis	necrosis	NN
cord-017640-i8h48ny6	292	27	factor	factor	NN
cord-017640-i8h48ny6	292	28	family	family	NN
cord-017640-i8h48ny6	292	29	Involvement	Involvement	NNP
cord-017640-i8h48ny6	292	30	of	of	IN
cord-017640-i8h48ny6	292	31	Fas	Fas	NNP
cord-017640-i8h48ny6	292	32	ligand	ligand	NN
cord-017640-i8h48ny6	292	33	and	and	CC
cord-017640-i8h48ny6	292	34	Fasmediated	fasmediated	JJ
cord-017640-i8h48ny6	292	35	pathway	pathway	NN
cord-017640-i8h48ny6	292	36	in	in	IN
cord-017640-i8h48ny6	292	37	the	the	DT
cord-017640-i8h48ny6	292	38	cytotoxicity	cytotoxicity	NN
cord-017640-i8h48ny6	292	39	of	of	IN
cord-017640-i8h48ny6	292	40	human	human	JJ
cord-017640-i8h48ny6	292	41	natural	natural	JJ
cord-017640-i8h48ny6	292	42	killer	killer	NN
cord-017640-i8h48ny6	292	43	cells	cell	NNS
cord-017640-i8h48ny6	293	1	Fas	Fas	NNP
cord-017640-i8h48ny6	293	2	ligand	ligand	NN
cord-017640-i8h48ny6	293	3	-	-	HYPH
cord-017640-i8h48ny6	293	4	induced	induce	VBN
cord-017640-i8h48ny6	293	5	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	293	6	as	as	IN
cord-017640-i8h48ny6	293	7	a	a	DT
cord-017640-i8h48ny6	293	8	mechanism	mechanism	NN
cord-017640-i8h48ny6	293	9	of	of	IN
cord-017640-i8h48ny6	293	10	immune	immune	JJ
cord-017640-i8h48ny6	293	11	privilege	privilege	NN
cord-017640-i8h48ny6	293	12	A	a	DT
cord-017640-i8h48ny6	293	13	role	role	NN
cord-017640-i8h48ny6	293	14	for	for	IN
cord-017640-i8h48ny6	293	15	CD95	CD95	NNP
cord-017640-i8h48ny6	293	16	ligand	ligand	NN
cord-017640-i8h48ny6	293	17	in	in	IN
cord-017640-i8h48ny6	293	18	preventing	prevent	VBG
cord-017640-i8h48ny6	293	19	graft	graft	NN
cord-017640-i8h48ny6	293	20	rejection	rejection	NN
cord-017640-i8h48ny6	293	21	Lymphoproliferation	Lymphoproliferation	NNP
cord-017640-i8h48ny6	293	22	disorder	disorder	NN
cord-017640-i8h48ny6	293	23	in	in	IN
cord-017640-i8h48ny6	293	24	mice	mouse	NNS
cord-017640-i8h48ny6	293	25	explained	explain	VBN
cord-017640-i8h48ny6	293	26	by	by	IN
cord-017640-i8h48ny6	293	27	defects	defect	NNS
cord-017640-i8h48ny6	293	28	in	in	IN
cord-017640-i8h48ny6	293	29	Fas	Fas	NNP
cord-017640-i8h48ny6	293	30	antigen	antigen	NN
cord-017640-i8h48ny6	293	31	that	that	WDT
cord-017640-i8h48ny6	293	32	mediates	mediate	VBZ
cord-017640-i8h48ny6	293	33	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	293	34	Aberrant	aberrant	JJ
cord-017640-i8h48ny6	293	35	transcription	transcription	NN
cord-017640-i8h48ny6	293	36	caused	cause	VBN
cord-017640-i8h48ny6	293	37	by	by	IN
cord-017640-i8h48ny6	293	38	the	the	DT
cord-017640-i8h48ny6	293	39	insertion	insertion	NN
cord-017640-i8h48ny6	293	40	of	of	IN
cord-017640-i8h48ny6	293	41	an	an	DT
cord-017640-i8h48ny6	293	42	early	early	JJ
cord-017640-i8h48ny6	293	43	transposable	transposable	JJ
cord-017640-i8h48ny6	293	44	element	element	NN
cord-017640-i8h48ny6	293	45	in	in	IN
cord-017640-i8h48ny6	293	46	an	an	DT
cord-017640-i8h48ny6	293	47	intron	intron	NN
cord-017640-i8h48ny6	293	48	of	of	IN
cord-017640-i8h48ny6	293	49	the	the	DT
cord-017640-i8h48ny6	293	50	Fas	Fas	NNP
cord-017640-i8h48ny6	293	51	antigen	antigen	NN
cord-017640-i8h48ny6	293	52	gene	gene	NN
cord-017640-i8h48ny6	293	53	of	of	IN
cord-017640-i8h48ny6	293	54	lpr	lpr	NNP
cord-017640-i8h48ny6	293	55	mice	mouse	NNS
cord-017640-i8h48ny6	294	1	The	the	DT
cord-017640-i8h48ny6	294	2	defect	defect	NN
cord-017640-i8h48ny6	294	3	in	in	IN
cord-017640-i8h48ny6	294	4	Fas	Fas	NNP
cord-017640-i8h48ny6	294	5	mRNA	mrna	NN
cord-017640-i8h48ny6	294	6	expression	expression	NN
cord-017640-i8h48ny6	294	7	in	in	IN
cord-017640-i8h48ny6	294	8	MRL	MRL	NNP
cord-017640-i8h48ny6	294	9	/	/	SYM
cord-017640-i8h48ny6	294	10	lpr	lpr	NN
cord-017640-i8h48ny6	294	11	mice	mouse	NNS
cord-017640-i8h48ny6	294	12	is	be	VBZ
cord-017640-i8h48ny6	294	13	associated	associate	VBN
cord-017640-i8h48ny6	294	14	with	with	IN
cord-017640-i8h48ny6	294	15	insertion	insertion	NN
cord-017640-i8h48ny6	294	16	of	of	IN
cord-017640-i8h48ny6	294	17	the	the	DT
cord-017640-i8h48ny6	294	18	retrotransposon	retrotransposon	NN
cord-017640-i8h48ny6	294	19	,	,	,
cord-017640-i8h48ny6	294	20	ETn	etn	IN
cord-017640-i8h48ny6	294	21	Autoimmunity	Autoimmunity	NNP
cord-017640-i8h48ny6	294	22	in	in	IN
cord-017640-i8h48ny6	294	23	mice	mouse	NNS
cord-017640-i8h48ny6	294	24	bearing	bearing	NN
cord-017640-i8h48ny6	294	25	lprcg	lprcg	NN
cord-017640-i8h48ny6	294	26	:	:	:
cord-017640-i8h48ny6	294	27	a	a	DT
cord-017640-i8h48ny6	294	28	novel	novel	JJ
cord-017640-i8h48ny6	294	29	mutant	mutant	JJ
cord-017640-i8h48ny6	294	30	gene	gene	NN
cord-017640-i8h48ny6	294	31	Generalized	generalize	VBN
cord-017640-i8h48ny6	294	32	lymphoproliferative	lymphoproliferative	JJ
cord-017640-i8h48ny6	294	33	disease	disease	NN
cord-017640-i8h48ny6	294	34	in	in	IN
cord-017640-i8h48ny6	294	35	mice	mouse	NNS
cord-017640-i8h48ny6	294	36	,	,	,
cord-017640-i8h48ny6	294	37	caused	cause	VBN
cord-017640-i8h48ny6	294	38	by	by	IN
cord-017640-i8h48ny6	294	39	a	a	DT
cord-017640-i8h48ny6	294	40	point	point	NN
cord-017640-i8h48ny6	294	41	mutation	mutation	NN
cord-017640-i8h48ny6	294	42	in	in	IN
cord-017640-i8h48ny6	294	43	the	the	DT
cord-017640-i8h48ny6	294	44	Fas	Fas	NNP
cord-017640-i8h48ny6	294	45	ligand	ligand	NN
cord-017640-i8h48ny6	295	1	The	the	DT
cord-017640-i8h48ny6	295	2	many	many	JJ
cord-017640-i8h48ny6	295	3	roles	role	NNS
cord-017640-i8h48ny6	295	4	of	of	IN
cord-017640-i8h48ny6	295	5	FAS	FAS	NNP
cord-017640-i8h48ny6	295	6	receptor	receptor	NN
cord-017640-i8h48ny6	295	7	signaling	signal	VBG
cord-017640-i8h48ny6	295	8	in	in	IN
cord-017640-i8h48ny6	295	9	the	the	DT
cord-017640-i8h48ny6	295	10	immune	immune	JJ
cord-017640-i8h48ny6	295	11	system	system	NN
cord-017640-i8h48ny6	295	12	Structure	Structure	NNP
cord-017640-i8h48ny6	295	13	of	of	IN
cord-017640-i8h48ny6	295	14	the	the	DT
cord-017640-i8h48ny6	295	15	human	human	JJ
cord-017640-i8h48ny6	295	16	APO-1	APO-1	NNP
cord-017640-i8h48ny6	295	17	gene	gene	NN
cord-017640-i8h48ny6	295	18	NMR	NMR	NNP
cord-017640-i8h48ny6	295	19	structure	structure	NN
cord-017640-i8h48ny6	295	20	and	and	CC
cord-017640-i8h48ny6	295	21	mutagenesis	mutagenesis	NN
cord-017640-i8h48ny6	295	22	of	of	IN
cord-017640-i8h48ny6	295	23	the	the	DT
cord-017640-i8h48ny6	295	24	Fas	Fas	NNP
cord-017640-i8h48ny6	295	25	(	(	-LRB-
cord-017640-i8h48ny6	295	26	APO-1	APO-1	NNP
cord-017640-i8h48ny6	295	27	/	/	SYM
cord-017640-i8h48ny6	295	28	CD95	CD95	NNP
cord-017640-i8h48ny6	295	29	)	)	-RRB-
cord-017640-i8h48ny6	295	30	death	death	NN
cord-017640-i8h48ny6	295	31	domain	domain	NN
cord-017640-i8h48ny6	296	1	The	the	DT
cord-017640-i8h48ny6	296	2	Fas	Fas	NNP
cord-017640-i8h48ny6	296	3	-	-	HYPH
cord-017640-i8h48ny6	296	4	FADD	FADD	NNP
cord-017640-i8h48ny6	296	5	death	death	NN
cord-017640-i8h48ny6	296	6	domain	domain	NN
cord-017640-i8h48ny6	296	7	complex	complex	JJ
cord-017640-i8h48ny6	296	8	structure	structure	NN
cord-017640-i8h48ny6	296	9	unravels	unravel	VBZ
cord-017640-i8h48ny6	296	10	signalling	signal	VBG
cord-017640-i8h48ny6	296	11	by	by	IN
cord-017640-i8h48ny6	296	12	receptor	receptor	NN
cord-017640-i8h48ny6	296	13	clustering	cluster	VBG
cord-017640-i8h48ny6	296	14	Solution	Solution	NNP
cord-017640-i8h48ny6	296	15	NMR	NMR	NNP
cord-017640-i8h48ny6	296	16	investigation	investigation	NN
cord-017640-i8h48ny6	296	17	of	of	IN
cord-017640-i8h48ny6	296	18	the	the	DT
cord-017640-i8h48ny6	296	19	CD95	CD95	NNP
cord-017640-i8h48ny6	296	20	/	/	SYM
cord-017640-i8h48ny6	296	21	FADD	FADD	NNP
cord-017640-i8h48ny6	296	22	homotypic	homotypic	NNP
cord-017640-i8h48ny6	296	23	death	death	NN
cord-017640-i8h48ny6	296	24	domain	domain	NN
cord-017640-i8h48ny6	296	25	complex	complex	NN
cord-017640-i8h48ny6	296	26	suggests	suggest	VBZ
cord-017640-i8h48ny6	296	27	lack	lack	NN
cord-017640-i8h48ny6	296	28	of	of	IN
cord-017640-i8h48ny6	296	29	engagement	engagement	NN
cord-017640-i8h48ny6	296	30	of	of	IN
cord-017640-i8h48ny6	296	31	the	the	DT
cord-017640-i8h48ny6	296	32	CD95	CD95	NNP
cord-017640-i8h48ny6	296	33	C	C	NNP
cord-017640-i8h48ny6	296	34	terminus	terminus	NN
cord-017640-i8h48ny6	297	1	The	the	DT
cord-017640-i8h48ny6	297	2	Fas	Fas	NNP
cord-017640-i8h48ny6	297	3	-	-	HYPH
cord-017640-i8h48ny6	297	4	FADD	FADD	NNP
cord-017640-i8h48ny6	297	5	death	death	NN
cord-017640-i8h48ny6	297	6	domain	domain	NN
cord-017640-i8h48ny6	297	7	complex	complex	JJ
cord-017640-i8h48ny6	297	8	structure	structure	NN
cord-017640-i8h48ny6	297	9	reveals	reveal	VBZ
cord-017640-i8h48ny6	297	10	the	the	DT
cord-017640-i8h48ny6	297	11	basis	basis	NN
cord-017640-i8h48ny6	297	12	of	of	IN
cord-017640-i8h48ny6	297	13	DISC	DISC	NNP
cord-017640-i8h48ny6	297	14	assembly	assembly	NN
cord-017640-i8h48ny6	297	15	and	and	CC
cord-017640-i8h48ny6	297	16	disease	disease	NN
cord-017640-i8h48ny6	297	17	mutations	mutation	NNS
cord-017640-i8h48ny6	297	18	Homotypic	Homotypic	NNP
cord-017640-i8h48ny6	297	19	FADD	FADD	NNP
cord-017640-i8h48ny6	297	20	interactions	interaction	NNS
cord-017640-i8h48ny6	297	21	through	through	IN
cord-017640-i8h48ny6	297	22	a	a	DT
cord-017640-i8h48ny6	297	23	conserved	conserve	VBN
cord-017640-i8h48ny6	297	24	RXDLL	rxdll	NN
cord-017640-i8h48ny6	297	25	motif	motif	NN
cord-017640-i8h48ny6	297	26	are	be	VBP
cord-017640-i8h48ny6	297	27	required	require	VBN
cord-017640-i8h48ny6	297	28	for	for	IN
cord-017640-i8h48ny6	297	29	death	death	NN
cord-017640-i8h48ny6	297	30	receptor	receptor	NN
cord-017640-i8h48ny6	297	31	-	-	HYPH
cord-017640-i8h48ny6	297	32	induced	induce	VBN
cord-017640-i8h48ny6	297	33	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	297	34	Inhibition	inhibition	NN
cord-017640-i8h48ny6	297	35	of	of	IN
cord-017640-i8h48ny6	297	36	death	death	NN
cord-017640-i8h48ny6	297	37	receptor	receptor	NN
cord-017640-i8h48ny6	297	38	signals	signal	NNS
cord-017640-i8h48ny6	297	39	by	by	IN
cord-017640-i8h48ny6	297	40	cellular	cellular	JJ
cord-017640-i8h48ny6	297	41	FLIP	FLIP	NNP
cord-017640-i8h48ny6	297	42	Viral	Viral	NNP
cord-017640-i8h48ny6	297	43	FLICE	flice	NN
cord-017640-i8h48ny6	297	44	-	-	HYPH
cord-017640-i8h48ny6	297	45	inhibitory	inhibitory	JJ
cord-017640-i8h48ny6	297	46	proteins	protein	NNS
cord-017640-i8h48ny6	297	47	(	(	-LRB-
cord-017640-i8h48ny6	297	48	FLIPs	flip	NNS
cord-017640-i8h48ny6	297	49	)	)	-RRB-
cord-017640-i8h48ny6	298	1	prevent	prevent	JJ
cord-017640-i8h48ny6	298	2	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	298	3	induced	induce	VBN
cord-017640-i8h48ny6	298	4	by	by	IN
cord-017640-i8h48ny6	298	5	death	death	NN
cord-017640-i8h48ny6	298	6	receptors	receptor	NNS
cord-017640-i8h48ny6	298	7	PED/	PED/	NNP
cord-017640-i8h48ny6	299	1	PEA-15	PEA-15	NNP
cord-017640-i8h48ny6	299	2	:	:	:
cord-017640-i8h48ny6	299	3	an	an	DT
cord-017640-i8h48ny6	299	4	anti	anti	JJ
cord-017640-i8h48ny6	299	5	-	-	JJ
cord-017640-i8h48ny6	299	6	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	299	7	molecule	molecule	NN
cord-017640-i8h48ny6	299	8	that	that	WDT
cord-017640-i8h48ny6	299	9	regulates	regulate	VBZ
cord-017640-i8h48ny6	300	1	FAS	FAS	NNP
cord-017640-i8h48ny6	300	2	/	/	SYM
cord-017640-i8h48ny6	300	3	TNFR1-induced	TNFR1-induced	NNP
cord-017640-i8h48ny6	300	4	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	301	1	Two	two	CD
cord-017640-i8h48ny6	301	2	CD95	CD95	NNP
cord-017640-i8h48ny6	301	3	(	(	-LRB-
cord-017640-i8h48ny6	301	4	APO-1	APO-1	NNP
cord-017640-i8h48ny6	301	5	/	/	SYM
cord-017640-i8h48ny6	301	6	Fas	Fas	NNP
cord-017640-i8h48ny6	301	7	)	)	-RRB-
cord-017640-i8h48ny6	301	8	signaling	signal	VBG
cord-017640-i8h48ny6	301	9	pathways	pathway	NNS
cord-017640-i8h48ny6	302	1	Two	two	CD
cord-017640-i8h48ny6	302	2	CD95	CD95	NNP
cord-017640-i8h48ny6	302	3	tumor	tumor	NN
cord-017640-i8h48ny6	302	4	classes	class	NNS
cord-017640-i8h48ny6	302	5	with	with	IN
cord-017640-i8h48ny6	302	6	different	different	JJ
cord-017640-i8h48ny6	302	7	sensitivities	sensitivity	NNS
cord-017640-i8h48ny6	302	8	to	to	IN
cord-017640-i8h48ny6	302	9	antitumor	antitumor	JJ
cord-017640-i8h48ny6	302	10	drugs	drug	NNS
cord-017640-i8h48ny6	302	11	CD95	CD95	NNP
cord-017640-i8h48ny6	302	12	engagement	engagement	NN
cord-017640-i8h48ny6	302	13	mediates	mediate	VBZ
cord-017640-i8h48ny6	302	14	actin	actin	NN
cord-017640-i8h48ny6	302	15	-	-	HYPH
cord-017640-i8h48ny6	302	16	independent	independent	JJ
cord-017640-i8h48ny6	302	17	and	and	CC
cord-017640-i8h48ny6	302	18	-dependent	-dependent	JJ
cord-017640-i8h48ny6	302	19	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	302	20	signals	signal	NNS
cord-017640-i8h48ny6	303	1	Signal	signal	NN
cord-017640-i8h48ny6	303	2	transduction	transduction	NN
cord-017640-i8h48ny6	303	3	mediated	mediate	VBN
cord-017640-i8h48ny6	303	4	by	by	IN
cord-017640-i8h48ny6	303	5	bid	bid	NN
cord-017640-i8h48ny6	303	6	,	,	,
cord-017640-i8h48ny6	303	7	a	a	DT
cord-017640-i8h48ny6	303	8	pro	pro	JJ
cord-017640-i8h48ny6	303	9	-	-	JJ
cord-017640-i8h48ny6	303	10	death	death	NN
cord-017640-i8h48ny6	303	11	Bcl-2	Bcl-2	NNP
cord-017640-i8h48ny6	303	12	family	family	NN
cord-017640-i8h48ny6	303	13	proteins	protein	NNS
cord-017640-i8h48ny6	303	14	,	,	,
cord-017640-i8h48ny6	303	15	connects	connect	VBZ
cord-017640-i8h48ny6	303	16	the	the	DT
cord-017640-i8h48ny6	303	17	death	death	NN
cord-017640-i8h48ny6	303	18	receptor	receptor	NN
cord-017640-i8h48ny6	303	19	and	and	CC
cord-017640-i8h48ny6	303	20	mitochondria	mitochondrion	NNS
cord-017640-i8h48ny6	303	21	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	303	22	pathways	pathway	NNS
cord-017640-i8h48ny6	303	23	Bid	bid	NN
cord-017640-i8h48ny6	303	24	-	-	HYPH
cord-017640-i8h48ny6	303	25	deficient	deficient	JJ
cord-017640-i8h48ny6	303	26	mice	mouse	NNS
cord-017640-i8h48ny6	303	27	are	be	VBP
cord-017640-i8h48ny6	303	28	resistant	resistant	JJ
cord-017640-i8h48ny6	303	29	to	to	IN
cord-017640-i8h48ny6	303	30	Fas	Fas	NNP
cord-017640-i8h48ny6	303	31	-	-	HYPH
cord-017640-i8h48ny6	303	32	induced	induce	VBN
cord-017640-i8h48ny6	303	33	hepatocellular	hepatocellular	RB
cord-017640-i8h48ny6	304	1	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	304	2	XIAP	XIAP	NNP
cord-017640-i8h48ny6	304	3	discriminates	discriminate	VBZ
cord-017640-i8h48ny6	304	4	between	between	IN
cord-017640-i8h48ny6	304	5	type	type	NN
cord-017640-i8h48ny6	304	6	I	-PRON-	PRP
cord-017640-i8h48ny6	304	7	and	and	CC
cord-017640-i8h48ny6	304	8	type	type	NN
cord-017640-i8h48ny6	304	9	II	II	NNP
cord-017640-i8h48ny6	304	10	FAS	FAS	NNP
cord-017640-i8h48ny6	304	11	-	-	HYPH
cord-017640-i8h48ny6	304	12	induced	induce	VBN
cord-017640-i8h48ny6	304	13	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	304	14	The	the	DT
cord-017640-i8h48ny6	304	15	c	c	NN
cord-017640-i8h48ny6	304	16	-	-	:
cord-017640-i8h48ny6	304	17	IAP-1	IAP-1	NNP
cord-017640-i8h48ny6	304	18	and	and	CC
cord-017640-i8h48ny6	304	19	c	c	LS
cord-017640-i8h48ny6	304	20	-	-	:
cord-017640-i8h48ny6	304	21	IAP-2	iap-2	JJ
cord-017640-i8h48ny6	304	22	proteins	protein	NNS
cord-017640-i8h48ny6	304	23	are	be	VBP
cord-017640-i8h48ny6	304	24	direct	direct	JJ
cord-017640-i8h48ny6	304	25	inhibitors	inhibitor	NNS
cord-017640-i8h48ny6	304	26	of	of	IN
cord-017640-i8h48ny6	304	27	specific	specific	JJ
cord-017640-i8h48ny6	304	28	caspases	caspase	NNS
cord-017640-i8h48ny6	304	29	X	x	NN
cord-017640-i8h48ny6	304	30	-	-	HYPH
cord-017640-i8h48ny6	304	31	linked	link	VBN
cord-017640-i8h48ny6	304	32	IAP	IAP	NNP
cord-017640-i8h48ny6	304	33	is	be	VBZ
cord-017640-i8h48ny6	304	34	a	a	DT
cord-017640-i8h48ny6	304	35	direct	direct	JJ
cord-017640-i8h48ny6	304	36	inhibitor	inhibitor	NN
cord-017640-i8h48ny6	304	37	of	of	IN
cord-017640-i8h48ny6	304	38	cell	cell	NN
cord-017640-i8h48ny6	304	39	-	-	HYPH
cord-017640-i8h48ny6	304	40	death	death	NN
cord-017640-i8h48ny6	304	41	proteases	protease	NNS
cord-017640-i8h48ny6	304	42	IAPs	iaps	NN
cord-017640-i8h48ny6	304	43	block	block	VBP
cord-017640-i8h48ny6	304	44	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	304	45	events	event	NNS
cord-017640-i8h48ny6	304	46	induced	induce	VBN
cord-017640-i8h48ny6	304	47	by	by	IN
cord-017640-i8h48ny6	304	48	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	304	49	and	and	CC
cord-017640-i8h48ny6	304	50	cytochrome	cytochrome	NN
cord-017640-i8h48ny6	304	51	c	c	NN
cord-017640-i8h48ny6	304	52	by	by	IN
cord-017640-i8h48ny6	304	53	direct	direct	JJ
cord-017640-i8h48ny6	304	54	inhibition	inhibition	NN
cord-017640-i8h48ny6	304	55	of	of	IN
cord-017640-i8h48ny6	304	56	distinct	distinct	JJ
cord-017640-i8h48ny6	304	57	caspases	caspase	NNS
cord-017640-i8h48ny6	304	58	Ubiquitinprotein	Ubiquitinprotein	NNP
cord-017640-i8h48ny6	304	59	ligase	ligase	NN
cord-017640-i8h48ny6	304	60	activity	activity	NN
cord-017640-i8h48ny6	304	61	of	of	IN
cord-017640-i8h48ny6	304	62	X	x	NN
cord-017640-i8h48ny6	304	63	-	-	HYPH
cord-017640-i8h48ny6	304	64	linked	link	VBN
cord-017640-i8h48ny6	304	65	inhibitor	inhibitor	NN
cord-017640-i8h48ny6	304	66	of	of	IN
cord-017640-i8h48ny6	304	67	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	304	68	protein	protein	NN
cord-017640-i8h48ny6	304	69	promotes	promote	VBZ
cord-017640-i8h48ny6	304	70	proteasomal	proteasomal	JJ
cord-017640-i8h48ny6	304	71	degradation	degradation	NN
cord-017640-i8h48ny6	304	72	of	of	IN
cord-017640-i8h48ny6	304	73	caspase-3	caspase-3	NNP
cord-017640-i8h48ny6	304	74	and	and	CC
cord-017640-i8h48ny6	304	75	enhances	enhance	VBZ
cord-017640-i8h48ny6	304	76	its	-PRON-	PRP$
cord-017640-i8h48ny6	304	77	anti	anti	JJ
cord-017640-i8h48ny6	304	78	-	-	JJ
cord-017640-i8h48ny6	304	79	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	304	80	effect	effect	NN
cord-017640-i8h48ny6	304	81	in	in	IN
cord-017640-i8h48ny6	304	82	Fas	Fas	NNP
cord-017640-i8h48ny6	304	83	-	-	HYPH
cord-017640-i8h48ny6	304	84	induced	induce	VBN
cord-017640-i8h48ny6	304	85	cell	cell	NN
cord-017640-i8h48ny6	304	86	death	death	NN
cord-017640-i8h48ny6	304	87	Smac	Smac	NNP
cord-017640-i8h48ny6	304	88	,	,	,
cord-017640-i8h48ny6	304	89	a	a	DT
cord-017640-i8h48ny6	304	90	mitochondrial	mitochondrial	JJ
cord-017640-i8h48ny6	304	91	protein	protein	NN
cord-017640-i8h48ny6	304	92	that	that	WDT
cord-017640-i8h48ny6	304	93	promotes	promote	VBZ
cord-017640-i8h48ny6	304	94	cytochrome	cytochrome	NN
cord-017640-i8h48ny6	304	95	c	c	NN
cord-017640-i8h48ny6	304	96	-	-	HYPH
cord-017640-i8h48ny6	304	97	dependent	dependent	JJ
cord-017640-i8h48ny6	304	98	caspase	caspase	NN
cord-017640-i8h48ny6	304	99	activation	activation	NN
cord-017640-i8h48ny6	304	100	by	by	IN
cord-017640-i8h48ny6	304	101	eliminating	eliminate	VBG
cord-017640-i8h48ny6	304	102	IAP	IAP	NNP
cord-017640-i8h48ny6	304	103	inhibition	inhibition	NN
cord-017640-i8h48ny6	304	104	Bcl-2	Bcl-2	NNP
cord-017640-i8h48ny6	304	105	and	and	CC
cord-017640-i8h48ny6	305	1	Bcl	Bcl	NNP
cord-017640-i8h48ny6	305	2	-	-	HYPH
cord-017640-i8h48ny6	305	3	xL	xL	NNP
cord-017640-i8h48ny6	305	4	inhibit	inhibit	NN
cord-017640-i8h48ny6	305	5	CD95-mediated	cd95-mediated	CD
cord-017640-i8h48ny6	305	6	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	305	7	by	by	IN
cord-017640-i8h48ny6	305	8	preventing	prevent	VBG
cord-017640-i8h48ny6	305	9	mitochondrial	mitochondrial	JJ
cord-017640-i8h48ny6	305	10	release	release	NN
cord-017640-i8h48ny6	305	11	of	of	IN
cord-017640-i8h48ny6	305	12	Smac	Smac	NNP
cord-017640-i8h48ny6	305	13	/	/	SYM
cord-017640-i8h48ny6	305	14	DIABLO	DIABLO	NNP
cord-017640-i8h48ny6	305	15	and	and	CC
cord-017640-i8h48ny6	305	16	subsequent	subsequent	JJ
cord-017640-i8h48ny6	305	17	inactivation	inactivation	NN
cord-017640-i8h48ny6	305	18	of	of	IN
cord-017640-i8h48ny6	305	19	X	x	NN
cord-017640-i8h48ny6	305	20	-	-	HYPH
cord-017640-i8h48ny6	305	21	linked	link	VBN
cord-017640-i8h48ny6	305	22	inhibitor	inhibitor	NN
cord-017640-i8h48ny6	305	23	-	-	HYPH
cord-017640-i8h48ny6	305	24	of	of	IN
cord-017640-i8h48ny6	305	25	-	-	HYPH
cord-017640-i8h48ny6	305	26	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	305	27	protein	protein	NN
cord-017640-i8h48ny6	305	28	Localization	localization	NN
cord-017640-i8h48ny6	305	29	of	of	IN
cord-017640-i8h48ny6	305	30	Fas	Fas	NNP
cord-017640-i8h48ny6	305	31	/	/	SYM
cord-017640-i8h48ny6	305	32	CD95	CD95	NNP
cord-017640-i8h48ny6	305	33	into	into	IN
cord-017640-i8h48ny6	305	34	the	the	DT
cord-017640-i8h48ny6	305	35	lipid	lipid	NN
cord-017640-i8h48ny6	305	36	rafts	raft	NNS
cord-017640-i8h48ny6	305	37	on	on	IN
cord-017640-i8h48ny6	305	38	down	down	IN
cord-017640-i8h48ny6	305	39	-	-	HYPH
cord-017640-i8h48ny6	305	40	modulation	modulation	NN
cord-017640-i8h48ny6	305	41	of	of	IN
cord-017640-i8h48ny6	305	42	the	the	DT
cord-017640-i8h48ny6	305	43	phosphatidylinositol	phosphatidylinositol	NN
cord-017640-i8h48ny6	305	44	3-kinase	3-kinase	CD
cord-017640-i8h48ny6	305	45	signaling	signal	VBG
cord-017640-i8h48ny6	305	46	pathway	pathway	NN
cord-017640-i8h48ny6	305	47	PTEN	PTEN	NNP
cord-017640-i8h48ny6	305	48	loss	loss	NN
cord-017640-i8h48ny6	305	49	promotes	promote	VBZ
cord-017640-i8h48ny6	305	50	mitochondrially	mitochondrially	RB
cord-017640-i8h48ny6	305	51	dependent	dependent	JJ
cord-017640-i8h48ny6	305	52	type	type	NN
cord-017640-i8h48ny6	305	53	II	II	NNP
cord-017640-i8h48ny6	305	54	Fas	Fas	NNP
cord-017640-i8h48ny6	305	55	-	-	HYPH
cord-017640-i8h48ny6	305	56	induced	induce	VBN
cord-017640-i8h48ny6	305	57	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	305	58	via	via	IN
cord-017640-i8h48ny6	306	1	PEA-15	PEA-15	NNP
cord-017640-i8h48ny6	306	2	Phosphatidylinositol	Phosphatidylinositol	NNP
cord-017640-i8h48ny6	306	3	3′-kinase	3′-kinase	CD
cord-017640-i8h48ny6	306	4	blocks	block	VBZ
cord-017640-i8h48ny6	306	5	CD95	CD95	NNP
cord-017640-i8h48ny6	306	6	aggregation	aggregation	NN
cord-017640-i8h48ny6	306	7	and	and	CC
cord-017640-i8h48ny6	306	8	caspase-8	caspase-8	JJ
cord-017640-i8h48ny6	306	9	cleavage	cleavage	NN
cord-017640-i8h48ny6	306	10	at	at	IN
cord-017640-i8h48ny6	306	11	the	the	DT
cord-017640-i8h48ny6	306	12	death	death	NN
cord-017640-i8h48ny6	306	13	-	-	HYPH
cord-017640-i8h48ny6	306	14	inducing	induce	VBG
cord-017640-i8h48ny6	306	15	signaling	signal	VBG
cord-017640-i8h48ny6	306	16	complex	complex	NN
cord-017640-i8h48ny6	306	17	by	by	IN
cord-017640-i8h48ny6	306	18	modulating	modulate	VBG
cord-017640-i8h48ny6	306	19	lateral	lateral	JJ
cord-017640-i8h48ny6	306	20	diffusion	diffusion	NN
cord-017640-i8h48ny6	306	21	of	of	IN
cord-017640-i8h48ny6	306	22	CD95	CD95	NNP
cord-017640-i8h48ny6	306	23	Actin	Actin	NNP
cord-017640-i8h48ny6	306	24	-	-	HYPH
cord-017640-i8h48ny6	306	25	independent	independent	JJ
cord-017640-i8h48ny6	306	26	exclusion	exclusion	NN
cord-017640-i8h48ny6	306	27	of	of	IN
cord-017640-i8h48ny6	306	28	CD95	CD95	NNP
cord-017640-i8h48ny6	306	29	by	by	IN
cord-017640-i8h48ny6	306	30	PI3K	PI3K	NNP
cord-017640-i8h48ny6	306	31	/	/	SYM
cord-017640-i8h48ny6	306	32	AKT	AKT	NNP
cord-017640-i8h48ny6	306	33	signalling	signalling	NN
cord-017640-i8h48ny6	306	34	:	:	:
cord-017640-i8h48ny6	306	35	implications	implication	NNS
cord-017640-i8h48ny6	306	36	for	for	IN
cord-017640-i8h48ny6	306	37	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	306	38	Phosphorylation	Phosphorylation	NNP
cord-017640-i8h48ny6	306	39	of	of	IN
cord-017640-i8h48ny6	306	40	PEA-15	PEA-15	NNP
cord-017640-i8h48ny6	306	41	switches	switch	VBZ
cord-017640-i8h48ny6	306	42	its	-PRON-	PRP$
cord-017640-i8h48ny6	306	43	binding	bind	VBG
cord-017640-i8h48ny6	306	44	specificity	specificity	NN
cord-017640-i8h48ny6	306	45	from	from	IN
cord-017640-i8h48ny6	306	46	ERK	ERK	NNP
cord-017640-i8h48ny6	306	47	/	/	SYM
cord-017640-i8h48ny6	306	48	MAPK	MAPK	NNP
cord-017640-i8h48ny6	306	49	to	to	IN
cord-017640-i8h48ny6	306	50	FADD	FADD	NNP
cord-017640-i8h48ny6	306	51	Protein	Protein	NNP
cord-017640-i8h48ny6	307	1	kinase	kinase	NNP
cord-017640-i8h48ny6	307	2	B/	B/	NNP
cord-017640-i8h48ny6	308	1	Akt	Akt	NNP
cord-017640-i8h48ny6	308	2	binds	bind	VBZ
cord-017640-i8h48ny6	308	3	and	and	CC
cord-017640-i8h48ny6	308	4	phosphorylates	phosphorylate	VBZ
cord-017640-i8h48ny6	308	5	PED	PED	NNP
cord-017640-i8h48ny6	308	6	/	/	SYM
cord-017640-i8h48ny6	308	7	PEA-15	PEA-15	NNP
cord-017640-i8h48ny6	308	8	,	,	,
cord-017640-i8h48ny6	308	9	stabilizing	stabilize	VBG
cord-017640-i8h48ny6	308	10	its	-PRON-	PRP$
cord-017640-i8h48ny6	308	11	antiapoptotic	antiapoptotic	JJ
cord-017640-i8h48ny6	308	12	action	action	NN
cord-017640-i8h48ny6	308	13	Bcl-2	Bcl-2	NNP
cord-017640-i8h48ny6	308	14	and	and	CC
cord-017640-i8h48ny6	309	1	Fas	Fas	NNP
cord-017640-i8h48ny6	309	2	/	/	SYM
cord-017640-i8h48ny6	309	3	APO-1	APO-1	NNP
cord-017640-i8h48ny6	309	4	regulate	regulate	VBP
cord-017640-i8h48ny6	309	5	distinct	distinct	JJ
cord-017640-i8h48ny6	309	6	pathways	pathway	NNS
cord-017640-i8h48ny6	309	7	to	to	IN
cord-017640-i8h48ny6	309	8	lymphocyte	lymphocyte	NN
cord-017640-i8h48ny6	309	9	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	310	1	Bcl-2	Bcl-2	NNP
cord-017640-i8h48ny6	310	2	protects	protect	VBZ
cord-017640-i8h48ny6	310	3	from	from	IN
cord-017640-i8h48ny6	310	4	lethal	lethal	JJ
cord-017640-i8h48ny6	310	5	hepatic	hepatic	JJ
cord-017640-i8h48ny6	310	6	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	310	7	induced	induce	VBN
cord-017640-i8h48ny6	310	8	by	by	IN
cord-017640-i8h48ny6	310	9	an	an	DT
cord-017640-i8h48ny6	310	10	anti	anti	JJ
cord-017640-i8h48ny6	310	11	-	-	JJ
cord-017640-i8h48ny6	310	12	Fas	Fas	NNP
cord-017640-i8h48ny6	310	13	antibody	antibody	NN
cord-017640-i8h48ny6	310	14	in	in	IN
cord-017640-i8h48ny6	310	15	mice	mouse	NNS
cord-017640-i8h48ny6	311	1	A	a	DT
cord-017640-i8h48ny6	311	2	bcl-2	bcl-2	NN
cord-017640-i8h48ny6	311	3	transgene	transgene	NN
cord-017640-i8h48ny6	311	4	expressed	express	VBN
cord-017640-i8h48ny6	311	5	in	in	IN
cord-017640-i8h48ny6	311	6	hepatocytes	hepatocyte	NNS
cord-017640-i8h48ny6	311	7	protects	protect	VBZ
cord-017640-i8h48ny6	311	8	mice	mouse	NNS
cord-017640-i8h48ny6	311	9	from	from	IN
cord-017640-i8h48ny6	311	10	fulminant	fulminant	JJ
cord-017640-i8h48ny6	311	11	liver	liver	NN
cord-017640-i8h48ny6	311	12	destruction	destruction	NN
cord-017640-i8h48ny6	311	13	but	but	CC
cord-017640-i8h48ny6	311	14	not	not	RB
cord-017640-i8h48ny6	311	15	from	from	IN
cord-017640-i8h48ny6	311	16	rapid	rapid	JJ
cord-017640-i8h48ny6	311	17	death	death	NN
cord-017640-i8h48ny6	311	18	induced	induce	VBN
cord-017640-i8h48ny6	311	19	by	by	IN
cord-017640-i8h48ny6	311	20	anti	anti	JJ
cord-017640-i8h48ny6	311	21	-	-	JJ
cord-017640-i8h48ny6	311	22	Fas	Fas	NNP
cord-017640-i8h48ny6	311	23	antibody	antibody	NN
cord-017640-i8h48ny6	311	24	injection	injection	NN
cord-017640-i8h48ny6	311	25	Fas	Fas	NNP
cord-017640-i8h48ny6	311	26	gene	gene	NN
cord-017640-i8h48ny6	311	27	mutations	mutation	NNS
cord-017640-i8h48ny6	311	28	in	in	IN
cord-017640-i8h48ny6	311	29	the	the	DT
cord-017640-i8h48ny6	311	30	Canale	Canale	NNP
cord-017640-i8h48ny6	311	31	-	-	HYPH
cord-017640-i8h48ny6	311	32	Smith	Smith	NNP
cord-017640-i8h48ny6	311	33	syndrome	syndrome	NN
cord-017640-i8h48ny6	311	34	,	,	,
cord-017640-i8h48ny6	311	35	an	an	DT
cord-017640-i8h48ny6	311	36	inherited	inherit	VBN
cord-017640-i8h48ny6	311	37	lymphoproliferative	lymphoproliferative	JJ
cord-017640-i8h48ny6	311	38	disorder	disorder	NN
cord-017640-i8h48ny6	311	39	associated	associate	VBN
cord-017640-i8h48ny6	311	40	with	with	IN
cord-017640-i8h48ny6	311	41	autoimmunity	autoimmunity	NN
cord-017640-i8h48ny6	311	42	Dominant	dominant	JJ
cord-017640-i8h48ny6	311	43	interfering	interfere	VBG
cord-017640-i8h48ny6	311	44	Fas	Fas	NNP
cord-017640-i8h48ny6	311	45	gene	gene	NN
cord-017640-i8h48ny6	311	46	mutations	mutation	NNS
cord-017640-i8h48ny6	311	47	impair	impair	VBP
cord-017640-i8h48ny6	311	48	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	311	49	in	in	IN
cord-017640-i8h48ny6	311	50	a	a	DT
cord-017640-i8h48ny6	311	51	human	human	JJ
cord-017640-i8h48ny6	311	52	autoimmune	autoimmune	JJ
cord-017640-i8h48ny6	311	53	lymphoproliferative	lymphoproliferative	JJ
cord-017640-i8h48ny6	311	54	syndrome	syndrome	NN
cord-017640-i8h48ny6	311	55	Mutations	Mutations	NNPS
cord-017640-i8h48ny6	311	56	in	in	IN
cord-017640-i8h48ny6	311	57	Fas	Fas	NNP
cord-017640-i8h48ny6	311	58	associated	associate	VBN
cord-017640-i8h48ny6	311	59	with	with	IN
cord-017640-i8h48ny6	311	60	human	human	JJ
cord-017640-i8h48ny6	311	61	lymphoproliferative	lymphoproliferative	JJ
cord-017640-i8h48ny6	311	62	syndrome	syndrome	NN
cord-017640-i8h48ny6	311	63	and	and	CC
cord-017640-i8h48ny6	311	64	autoimmunity	autoimmunity	NN
cord-017640-i8h48ny6	312	1	Chronic	chronic	JJ
cord-017640-i8h48ny6	312	2	lymphadenopathy	lymphadenopathy	JJ
cord-017640-i8h48ny6	312	3	simulating	simulate	VBG
cord-017640-i8h48ny6	312	4	malignant	malignant	JJ
cord-017640-i8h48ny6	312	5	lymphoma	lymphoma	NN
cord-017640-i8h48ny6	312	6	Lymphoproliferative	lymphoproliferative	JJ
cord-017640-i8h48ny6	312	7	syndrome	syndrome	NN
cord-017640-i8h48ny6	312	8	with	with	IN
cord-017640-i8h48ny6	312	9	autoimmunity	autoimmunity	NN
cord-017640-i8h48ny6	312	10	:	:	:
cord-017640-i8h48ny6	312	11	a	a	DT
cord-017640-i8h48ny6	312	12	possible	possible	JJ
cord-017640-i8h48ny6	312	13	genetic	genetic	JJ
cord-017640-i8h48ny6	312	14	basis	basis	NN
cord-017640-i8h48ny6	312	15	for	for	IN
cord-017640-i8h48ny6	312	16	dominant	dominant	JJ
cord-017640-i8h48ny6	312	17	expression	expression	NN
cord-017640-i8h48ny6	312	18	of	of	IN
cord-017640-i8h48ny6	312	19	the	the	DT
cord-017640-i8h48ny6	312	20	clinical	clinical	JJ
cord-017640-i8h48ny6	312	21	manifestations	manifestation	NNS
cord-017640-i8h48ny6	313	1	The	the	DT
cord-017640-i8h48ny6	313	2	development	development	NN
cord-017640-i8h48ny6	313	3	of	of	IN
cord-017640-i8h48ny6	313	4	lymphomas	lymphoma	NNS
cord-017640-i8h48ny6	313	5	in	in	IN
cord-017640-i8h48ny6	313	6	families	family	NNS
cord-017640-i8h48ny6	313	7	with	with	IN
cord-017640-i8h48ny6	313	8	autoimmune	autoimmune	JJ
cord-017640-i8h48ny6	313	9	lymphoproliferative	lymphoproliferative	JJ
cord-017640-i8h48ny6	313	10	syndrome	syndrome	NN
cord-017640-i8h48ny6	313	11	with	with	IN
cord-017640-i8h48ny6	313	12	germline	germline	JJ
cord-017640-i8h48ny6	313	13	Fas	Fas	NNP
cord-017640-i8h48ny6	313	14	mutations	mutation	NNS
cord-017640-i8h48ny6	313	15	and	and	CC
cord-017640-i8h48ny6	313	16	defective	defective	JJ
cord-017640-i8h48ny6	313	17	lymphocyte	lymphocyte	NN
cord-017640-i8h48ny6	313	18	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	313	19	FLICE	FLICE	NNP
cord-017640-i8h48ny6	313	20	-	-	HYPH
cord-017640-i8h48ny6	313	21	inhibitory	inhibitory	JJ
cord-017640-i8h48ny6	313	22	protein	protein	NN
cord-017640-i8h48ny6	313	23	is	be	VBZ
cord-017640-i8h48ny6	313	24	a	a	DT
cord-017640-i8h48ny6	313	25	key	key	JJ
cord-017640-i8h48ny6	313	26	regulator	regulator	NN
cord-017640-i8h48ny6	313	27	of	of	IN
cord-017640-i8h48ny6	313	28	germinal	germinal	JJ
cord-017640-i8h48ny6	313	29	center	center	NN
cord-017640-i8h48ny6	313	30	B	B	NNP
cord-017640-i8h48ny6	313	31	cell	cell	NN
cord-017640-i8h48ny6	313	32	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	313	33	Primary	primary	JJ
cord-017640-i8h48ny6	313	34	diffuse	diffuse	VBP
cord-017640-i8h48ny6	313	35	large	large	JJ
cord-017640-i8h48ny6	313	36	B	b	NN
cord-017640-i8h48ny6	313	37	-	-	HYPH
cord-017640-i8h48ny6	313	38	cell	cell	NN
cord-017640-i8h48ny6	313	39	lymphomas	lymphoma	NNS
cord-017640-i8h48ny6	313	40	of	of	IN
cord-017640-i8h48ny6	313	41	the	the	DT
cord-017640-i8h48ny6	313	42	central	central	JJ
cord-017640-i8h48ny6	313	43	nervous	nervous	JJ
cord-017640-i8h48ny6	313	44	system	system	NN
cord-017640-i8h48ny6	313	45	are	be	VBP
cord-017640-i8h48ny6	313	46	targeted	target	VBN
cord-017640-i8h48ny6	313	47	by	by	IN
cord-017640-i8h48ny6	313	48	aberrant	aberrant	JJ
cord-017640-i8h48ny6	313	49	somatic	somatic	JJ
cord-017640-i8h48ny6	313	50	hypermutation	hypermutation	NN
cord-017640-i8h48ny6	314	1	The	the	DT
cord-017640-i8h48ny6	314	2	origin	origin	NN
cord-017640-i8h48ny6	314	3	of	of	IN
cord-017640-i8h48ny6	314	4	CD95-gene	CD95-gene	NNP
cord-017640-i8h48ny6	314	5	mutations	mutation	NNS
cord-017640-i8h48ny6	314	6	in	in	IN
cord-017640-i8h48ny6	314	7	B	b	NN
cord-017640-i8h48ny6	314	8	-	-	HYPH
cord-017640-i8h48ny6	314	9	cell	cell	NN
cord-017640-i8h48ny6	314	10	lymphoma	lymphoma	NN
cord-017640-i8h48ny6	315	1	Does	do	VBZ
cord-017640-i8h48ny6	315	2	CD95	CD95	NNP
cord-017640-i8h48ny6	315	3	have	have	VB
cord-017640-i8h48ny6	315	4	tumor	tumor	NN
cord-017640-i8h48ny6	315	5	promoting	promote	VBG
cord-017640-i8h48ny6	315	6	activities	activity	NNS
cord-017640-i8h48ny6	315	7	?	?	.
cord-017640-i8h48ny6	316	1	The	the	DT
cord-017640-i8h48ny6	316	2	relevance	relevance	NN
cord-017640-i8h48ny6	316	3	of	of	IN
cord-017640-i8h48ny6	316	4	NF	nf	NN
cord-017640-i8h48ny6	316	5	-	-	HYPH
cord-017640-i8h48ny6	316	6	kappaB	kappaB	NNP
cord-017640-i8h48ny6	316	7	for	for	IN
cord-017640-i8h48ny6	316	8	CD95	CD95	NNP
cord-017640-i8h48ny6	316	9	signaling	signal	VBG
cord-017640-i8h48ny6	316	10	in	in	IN
cord-017640-i8h48ny6	316	11	tumor	tumor	NN
cord-017640-i8h48ny6	316	12	cells	cell	NNS
cord-017640-i8h48ny6	316	13	Induction	induction	NN
cord-017640-i8h48ny6	316	14	of	of	IN
cord-017640-i8h48ny6	316	15	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	316	16	and	and	CC
cord-017640-i8h48ny6	316	17	activation	activation	NN
cord-017640-i8h48ny6	316	18	of	of	IN
cord-017640-i8h48ny6	316	19	NF	NF	NNP
cord-017640-i8h48ny6	316	20	-	-	HYPH
cord-017640-i8h48ny6	316	21	kappaB	kappaB	NNP
cord-017640-i8h48ny6	316	22	by	by	IN
cord-017640-i8h48ny6	316	23	CD95	CD95	NNP
cord-017640-i8h48ny6	316	24	require	require	VBP
cord-017640-i8h48ny6	316	25	different	different	JJ
cord-017640-i8h48ny6	316	26	signalling	signal	VBG
cord-017640-i8h48ny6	316	27	thresholds	threshold	NNS
cord-017640-i8h48ny6	316	28	CD95	CD95	NNP
cord-017640-i8h48ny6	316	29	ligand	ligand	NN
cord-017640-i8h48ny6	316	30	induces	induce	VBZ
cord-017640-i8h48ny6	316	31	motility	motility	NN
cord-017640-i8h48ny6	316	32	and	and	CC
cord-017640-i8h48ny6	316	33	invasiveness	invasiveness	NN
cord-017640-i8h48ny6	316	34	of	of	IN
cord-017640-i8h48ny6	316	35	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	316	36	-	-	HYPH
cord-017640-i8h48ny6	316	37	resistant	resistant	JJ
cord-017640-i8h48ny6	316	38	tumor	tumor	NN
cord-017640-i8h48ny6	316	39	cells	cell	NNS
cord-017640-i8h48ny6	317	1	CD95	CD95	NNP
cord-017640-i8h48ny6	317	2	signaling	signal	VBG
cord-017640-i8h48ny6	317	3	via	via	IN
cord-017640-i8h48ny6	317	4	ceramide	ceramide	NN
cord-017640-i8h48ny6	317	5	-	-	HYPH
cord-017640-i8h48ny6	317	6	rich	rich	JJ
cord-017640-i8h48ny6	317	7	membrane	membrane	NN
cord-017640-i8h48ny6	317	8	rafts	raft	NNS
cord-017640-i8h48ny6	318	1	Ligand	ligand	NN
cord-017640-i8h48ny6	318	2	-	-	HYPH
cord-017640-i8h48ny6	318	3	independent	independent	JJ
cord-017640-i8h48ny6	318	4	redistribution	redistribution	NN
cord-017640-i8h48ny6	318	5	of	of	IN
cord-017640-i8h48ny6	318	6	Fas	Fas	NNP
cord-017640-i8h48ny6	318	7	(	(	-LRB-
cord-017640-i8h48ny6	318	8	CD95	CD95	NNP
cord-017640-i8h48ny6	318	9	)	)	-RRB-
cord-017640-i8h48ny6	318	10	into	into	IN
cord-017640-i8h48ny6	318	11	lipid	lipid	NN
cord-017640-i8h48ny6	318	12	rafts	raft	NNS
cord-017640-i8h48ny6	318	13	mediates	mediate	VBZ
cord-017640-i8h48ny6	318	14	clonotypic	clonotypic	NNP
cord-017640-i8h48ny6	318	15	T	T	NNP
cord-017640-i8h48ny6	318	16	cell	cell	NN
cord-017640-i8h48ny6	318	17	death	death	NN
cord-017640-i8h48ny6	318	18	Fas	Fas	NNP
cord-017640-i8h48ny6	318	19	receptor	receptor	NN
cord-017640-i8h48ny6	318	20	clustering	clustering	NN
cord-017640-i8h48ny6	318	21	and	and	CC
cord-017640-i8h48ny6	318	22	involvement	involvement	NN
cord-017640-i8h48ny6	318	23	of	of	IN
cord-017640-i8h48ny6	318	24	the	the	DT
cord-017640-i8h48ny6	318	25	death	death	NN
cord-017640-i8h48ny6	318	26	receptor	receptor	NN
cord-017640-i8h48ny6	318	27	pathway	pathway	NN
cord-017640-i8h48ny6	318	28	in	in	IN
cord-017640-i8h48ny6	318	29	rituximabmediated	rituximabmediate	VBN
cord-017640-i8h48ny6	318	30	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	318	31	with	with	IN
cord-017640-i8h48ny6	318	32	concomitant	concomitant	JJ
cord-017640-i8h48ny6	318	33	sensitization	sensitization	NN
cord-017640-i8h48ny6	318	34	of	of	IN
cord-017640-i8h48ny6	318	35	lymphoma	lymphoma	NN
cord-017640-i8h48ny6	318	36	B	b	NN
cord-017640-i8h48ny6	318	37	cells	cell	NNS
cord-017640-i8h48ny6	318	38	to	to	IN
cord-017640-i8h48ny6	319	1	fas	fas	NNP
cord-017640-i8h48ny6	319	2	-	-	HYPH
cord-017640-i8h48ny6	319	3	induced	induce	VBN
cord-017640-i8h48ny6	319	4	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	320	1	Resveratrol	resveratrol	NN
cord-017640-i8h48ny6	320	2	-	-	HYPH
cord-017640-i8h48ny6	320	3	induced	induce	VBN
cord-017640-i8h48ny6	320	4	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	320	5	is	be	VBZ
cord-017640-i8h48ny6	320	6	associated	associate	VBN
cord-017640-i8h48ny6	320	7	with	with	IN
cord-017640-i8h48ny6	320	8	Fas	Fas	NNP
cord-017640-i8h48ny6	320	9	redistribution	redistribution	NN
cord-017640-i8h48ny6	320	10	in	in	IN
cord-017640-i8h48ny6	320	11	the	the	DT
cord-017640-i8h48ny6	320	12	rafts	raft	NNS
cord-017640-i8h48ny6	320	13	and	and	CC
cord-017640-i8h48ny6	320	14	the	the	DT
cord-017640-i8h48ny6	320	15	formation	formation	NN
cord-017640-i8h48ny6	320	16	of	of	IN
cord-017640-i8h48ny6	320	17	a	a	DT
cord-017640-i8h48ny6	320	18	death	death	NN
cord-017640-i8h48ny6	320	19	-	-	HYPH
cord-017640-i8h48ny6	320	20	inducing	induce	VBG
cord-017640-i8h48ny6	320	21	signaling	signal	VBG
cord-017640-i8h48ny6	320	22	complex	complex	NN
cord-017640-i8h48ny6	320	23	in	in	IN
cord-017640-i8h48ny6	320	24	colon	colon	NN
cord-017640-i8h48ny6	320	25	cancer	cancer	NN
cord-017640-i8h48ny6	320	26	cells	cell	NNS
cord-017640-i8h48ny6	320	27	Redistribution	redistribution	NN
cord-017640-i8h48ny6	320	28	of	of	IN
cord-017640-i8h48ny6	320	29	CD95	CD95	NNP
cord-017640-i8h48ny6	320	30	,	,	,
cord-017640-i8h48ny6	320	31	DR4	DR4	NNP
cord-017640-i8h48ny6	320	32	and	and	CC
cord-017640-i8h48ny6	320	33	DR5	DR5	NNP
cord-017640-i8h48ny6	320	34	in	in	IN
cord-017640-i8h48ny6	320	35	rafts	raft	NNS
cord-017640-i8h48ny6	320	36	accounts	account	VBZ
cord-017640-i8h48ny6	320	37	for	for	IN
cord-017640-i8h48ny6	320	38	the	the	DT
cord-017640-i8h48ny6	320	39	synergistic	synergistic	JJ
cord-017640-i8h48ny6	320	40	toxicity	toxicity	NN
cord-017640-i8h48ny6	320	41	of	of	IN
cord-017640-i8h48ny6	320	42	resveratrol	resveratrol	NN
cord-017640-i8h48ny6	320	43	and	and	CC
cord-017640-i8h48ny6	320	44	death	death	NN
cord-017640-i8h48ny6	320	45	receptor	receptor	NN
cord-017640-i8h48ny6	320	46	ligands	ligand	NNS
cord-017640-i8h48ny6	320	47	in	in	IN
cord-017640-i8h48ny6	320	48	colon	colon	NN
cord-017640-i8h48ny6	320	49	carcinoma	carcinoma	NN
cord-017640-i8h48ny6	320	50	cells	cell	NNS
cord-017640-i8h48ny6	321	1	Intracellular	Intracellular	NNP
cord-017640-i8h48ny6	321	2	triggering	trigger	VBG
cord-017640-i8h48ny6	321	3	of	of	IN
cord-017640-i8h48ny6	321	4	Fas	Fas	NNP
cord-017640-i8h48ny6	321	5	aggregation	aggregation	NN
cord-017640-i8h48ny6	321	6	and	and	CC
cord-017640-i8h48ny6	321	7	recruitment	recruitment	NN
cord-017640-i8h48ny6	321	8	of	of	IN
cord-017640-i8h48ny6	321	9	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	321	10	molecules	molecule	NNS
cord-017640-i8h48ny6	321	11	into	into	IN
cord-017640-i8h48ny6	321	12	Fas	Fas	NNP
cord-017640-i8h48ny6	321	13	-	-	HYPH
cord-017640-i8h48ny6	321	14	enriched	enrich	VBN
cord-017640-i8h48ny6	321	15	rafts	raft	NNS
cord-017640-i8h48ny6	321	16	in	in	IN
cord-017640-i8h48ny6	321	17	selective	selective	JJ
cord-017640-i8h48ny6	321	18	tumor	tumor	NN
cord-017640-i8h48ny6	321	19	cell	cell	NN
cord-017640-i8h48ny6	321	20	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	322	1	Edelfosine	edelfosine	NN
cord-017640-i8h48ny6	322	2	and	and	CC
cord-017640-i8h48ny6	322	3	perifosine	perifosine	NN
cord-017640-i8h48ny6	322	4	induce	induce	VBP
cord-017640-i8h48ny6	322	5	selective	selective	JJ
cord-017640-i8h48ny6	322	6	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	322	7	in	in	IN
cord-017640-i8h48ny6	322	8	multiple	multiple	JJ
cord-017640-i8h48ny6	322	9	myeloma	myeloma	NN
cord-017640-i8h48ny6	322	10	by	by	IN
cord-017640-i8h48ny6	322	11	recruitment	recruitment	NN
cord-017640-i8h48ny6	322	12	of	of	IN
cord-017640-i8h48ny6	322	13	death	death	NN
cord-017640-i8h48ny6	322	14	receptors	receptor	NNS
cord-017640-i8h48ny6	322	15	and	and	CC
cord-017640-i8h48ny6	322	16	downstream	downstream	JJ
cord-017640-i8h48ny6	322	17	signaling	signal	VBG
cord-017640-i8h48ny6	322	18	molecules	molecule	NNS
cord-017640-i8h48ny6	322	19	into	into	IN
cord-017640-i8h48ny6	322	20	lipid	lipid	NN
cord-017640-i8h48ny6	322	21	rafts	raft	NNS
cord-017640-i8h48ny6	323	1	Cytoskeleton	Cytoskeleton	NNP
cord-017640-i8h48ny6	323	2	-	-	HYPH
cord-017640-i8h48ny6	323	3	mediated	mediate	VBN
cord-017640-i8h48ny6	323	4	death	death	NN
cord-017640-i8h48ny6	323	5	receptor	receptor	NN
cord-017640-i8h48ny6	323	6	and	and	CC
cord-017640-i8h48ny6	323	7	ligand	ligand	NN
cord-017640-i8h48ny6	323	8	concentration	concentration	NN
cord-017640-i8h48ny6	323	9	in	in	IN
cord-017640-i8h48ny6	323	10	lipid	lipid	NN
cord-017640-i8h48ny6	323	11	rafts	raft	NNS
cord-017640-i8h48ny6	323	12	forms	form	VBZ
cord-017640-i8h48ny6	323	13	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	323	14	-	-	HYPH
cord-017640-i8h48ny6	323	15	promoting	promote	VBG
cord-017640-i8h48ny6	323	16	clusters	cluster	NNS
cord-017640-i8h48ny6	323	17	in	in	IN
cord-017640-i8h48ny6	323	18	cancer	cancer	NN
cord-017640-i8h48ny6	324	1	chemotherapy	chemotherapy	NN
cord-017640-i8h48ny6	325	1	Cisplatin	cisplatin	NN
cord-017640-i8h48ny6	325	2	-	-	HYPH
cord-017640-i8h48ny6	325	3	induced	induce	VBN
cord-017640-i8h48ny6	325	4	CD95	CD95	NNP
cord-017640-i8h48ny6	325	5	redistribution	redistribution	NN
cord-017640-i8h48ny6	325	6	into	into	IN
cord-017640-i8h48ny6	325	7	membrane	membrane	NN
cord-017640-i8h48ny6	325	8	lipid	lipid	NN
cord-017640-i8h48ny6	325	9	rafts	raft	NNS
cord-017640-i8h48ny6	325	10	of	of	IN
cord-017640-i8h48ny6	325	11	HT29	HT29	NNP
cord-017640-i8h48ny6	325	12	human	human	JJ
cord-017640-i8h48ny6	325	13	colon	colon	NN
cord-017640-i8h48ny6	325	14	cancer	cancer	NN
cord-017640-i8h48ny6	325	15	cells	cell	NNS
cord-017640-i8h48ny6	325	16	Redistribution	redistribution	NN
cord-017640-i8h48ny6	325	17	of	of	IN
cord-017640-i8h48ny6	325	18	CD95	CD95	NNP
cord-017640-i8h48ny6	325	19	into	into	IN
cord-017640-i8h48ny6	325	20	the	the	DT
cord-017640-i8h48ny6	325	21	lipid	lipid	NN
cord-017640-i8h48ny6	325	22	rafts	raft	NNS
cord-017640-i8h48ny6	325	23	to	to	TO
cord-017640-i8h48ny6	325	24	treat	treat	VB
cord-017640-i8h48ny6	325	25	cancer	cancer	NN
cord-017640-i8h48ny6	325	26	cells	cell	NNS
cord-017640-i8h48ny6	325	27	?	?	.
cord-017640-i8h48ny6	326	1	Redox	redox	NN
cord-017640-i8h48ny6	326	2	amplification	amplification	NN
cord-017640-i8h48ny6	326	3	of	of	IN
cord-017640-i8h48ny6	326	4	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	326	5	by	by	IN
cord-017640-i8h48ny6	326	6	caspase	caspase	NN
cord-017640-i8h48ny6	326	7	-	-	HYPH
cord-017640-i8h48ny6	326	8	dependent	dependent	JJ
cord-017640-i8h48ny6	326	9	cleavage	cleavage	NN
cord-017640-i8h48ny6	326	10	of	of	IN
cord-017640-i8h48ny6	326	11	glutaredoxin	glutaredoxin	NNP
cord-017640-i8h48ny6	326	12	1	1	CD
cord-017640-i8h48ny6	326	13	and	and	CC
cord-017640-i8h48ny6	326	14	S	s	NN
cord-017640-i8h48ny6	326	15	-	-	HYPH
cord-017640-i8h48ny6	326	16	glutathionylation	glutathionylation	NN
cord-017640-i8h48ny6	326	17	of	of	IN
cord-017640-i8h48ny6	326	18	Fas	Fas	NNP
cord-017640-i8h48ny6	326	19	Purification	Purification	NNP
cord-017640-i8h48ny6	326	20	and	and	CC
cord-017640-i8h48ny6	326	21	molecular	molecular	JJ
cord-017640-i8h48ny6	326	22	cloning	cloning	NN
cord-017640-i8h48ny6	326	23	of	of	IN
cord-017640-i8h48ny6	326	24	the	the	DT
cord-017640-i8h48ny6	326	25	APO-1	APO-1	NNP
cord-017640-i8h48ny6	326	26	cell	cell	NN
cord-017640-i8h48ny6	326	27	surface	surface	NN
cord-017640-i8h48ny6	326	28	antigen	antigen	NN
cord-017640-i8h48ny6	326	29	,	,	,
cord-017640-i8h48ny6	326	30	a	a	DT
cord-017640-i8h48ny6	326	31	member	member	NN
cord-017640-i8h48ny6	326	32	of	of	IN
cord-017640-i8h48ny6	326	33	the	the	DT
cord-017640-i8h48ny6	326	34	tumor	tumor	NN
cord-017640-i8h48ny6	326	35	necrosis	necrosis	NN
cord-017640-i8h48ny6	326	36	factor	factor	NN
cord-017640-i8h48ny6	326	37	/	/	SYM
cord-017640-i8h48ny6	326	38	nerve	nerve	NN
cord-017640-i8h48ny6	326	39	growth	growth	NN
cord-017640-i8h48ny6	326	40	factor	factor	NN
cord-017640-i8h48ny6	326	41	receptor	receptor	NN
cord-017640-i8h48ny6	326	42	superfamily	superfamily	NN
cord-017640-i8h48ny6	326	43	.	.	.
cord-017640-i8h48ny6	327	1	Sequence	sequence	NN
cord-017640-i8h48ny6	327	2	identity	identity	NN
cord-017640-i8h48ny6	327	3	with	with	IN
cord-017640-i8h48ny6	327	4	the	the	DT
cord-017640-i8h48ny6	327	5	Fas	Fas	NNP
cord-017640-i8h48ny6	327	6	antigen	antigen	NN
cord-017640-i8h48ny6	327	7	Ceramide	Ceramide	NNP
cord-017640-i8h48ny6	327	8	-	-	HYPH
cord-017640-i8h48ny6	327	9	mediated	mediate	VBN
cord-017640-i8h48ny6	327	10	clustering	clustering	NN
cord-017640-i8h48ny6	327	11	is	be	VBZ
cord-017640-i8h48ny6	327	12	required	require	VBN
cord-017640-i8h48ny6	327	13	for	for	IN
cord-017640-i8h48ny6	327	14	CD95-DISC	CD95-DISC	NNP
cord-017640-i8h48ny6	327	15	formation	formation	NN
cord-017640-i8h48ny6	327	16	S	s	NN
cord-017640-i8h48ny6	327	17	-	-	HYPH
cord-017640-i8h48ny6	327	18	glutathionylation	glutathionylation	NNP
cord-017640-i8h48ny6	327	19	uncouples	uncouple	NNS
cord-017640-i8h48ny6	327	20	eNOS	eNOS	NNP
cord-017640-i8h48ny6	327	21	and	and	CC
cord-017640-i8h48ny6	327	22	regulates	regulate	VBZ
cord-017640-i8h48ny6	327	23	its	-PRON-	PRP$
cord-017640-i8h48ny6	327	24	cellular	cellular	JJ
cord-017640-i8h48ny6	327	25	and	and	CC
cord-017640-i8h48ny6	327	26	vascular	vascular	JJ
cord-017640-i8h48ny6	327	27	function	function	NN
cord-017640-i8h48ny6	327	28	S	s	NN
cord-017640-i8h48ny6	327	29	-	-	HYPH
cord-017640-i8h48ny6	327	30	nitrosylation	nitrosylation	NN
cord-017640-i8h48ny6	327	31	of	of	IN
cord-017640-i8h48ny6	327	32	the	the	DT
cord-017640-i8h48ny6	327	33	death	death	NN
cord-017640-i8h48ny6	327	34	receptor	receptor	NN
cord-017640-i8h48ny6	327	35	fas	fas	NNP
cord-017640-i8h48ny6	327	36	promotes	promote	VBZ
cord-017640-i8h48ny6	327	37	fas	fas	NNP
cord-017640-i8h48ny6	327	38	ligand	ligand	NN
cord-017640-i8h48ny6	327	39	-	-	HYPH
cord-017640-i8h48ny6	327	40	mediated	mediate	VBN
cord-017640-i8h48ny6	327	41	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	327	42	in	in	IN
cord-017640-i8h48ny6	327	43	cancer	cancer	NN
cord-017640-i8h48ny6	327	44	cells	cell	NNS
cord-017640-i8h48ny6	328	1	Palmitoylation	Palmitoylation	NNP
cord-017640-i8h48ny6	328	2	is	be	VBZ
cord-017640-i8h48ny6	328	3	required	require	VBN
cord-017640-i8h48ny6	328	4	for	for	IN
cord-017640-i8h48ny6	328	5	efficient	efficient	JJ
cord-017640-i8h48ny6	328	6	Fas	Fas	NNP
cord-017640-i8h48ny6	328	7	cell	cell	NN
cord-017640-i8h48ny6	328	8	death	death	NN
cord-017640-i8h48ny6	328	9	signaling	signal	VBG
cord-017640-i8h48ny6	328	10	Palmitoylation	Palmitoylation	NNP
cord-017640-i8h48ny6	328	11	of	of	IN
cord-017640-i8h48ny6	328	12	CD95	CD95	NNP
cord-017640-i8h48ny6	328	13	facilitates	facilitate	VBZ
cord-017640-i8h48ny6	328	14	formation	formation	NN
cord-017640-i8h48ny6	328	15	of	of	IN
cord-017640-i8h48ny6	328	16	SDS	sds	NN
cord-017640-i8h48ny6	328	17	-	-	HYPH
cord-017640-i8h48ny6	328	18	stable	stable	JJ
cord-017640-i8h48ny6	328	19	receptor	receptor	NN
cord-017640-i8h48ny6	328	20	aggregates	aggregate	NNS
cord-017640-i8h48ny6	328	21	that	that	WDT
cord-017640-i8h48ny6	328	22	initiate	initiate	VBP
cord-017640-i8h48ny6	328	23	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	328	24	signaling	signal	VBG
cord-017640-i8h48ny6	328	25	The	the	DT
cord-017640-i8h48ny6	328	26	role	role	NN
cord-017640-i8h48ny6	328	27	of	of	IN
cord-017640-i8h48ny6	328	28	receptor	receptor	NN
cord-017640-i8h48ny6	328	29	internalization	internalization	NN
cord-017640-i8h48ny6	328	30	in	in	IN
cord-017640-i8h48ny6	328	31	CD95	CD95	NNP
cord-017640-i8h48ny6	328	32	signaling	signal	VBG
cord-017640-i8h48ny6	328	33	CD95	CD95	NNP
cord-017640-i8h48ny6	328	34	triggers	trigger	VBZ
cord-017640-i8h48ny6	328	35	Orai1-mediated	Orai1-mediated	NNP
cord-017640-i8h48ny6	328	36	localized	localize	VBN
cord-017640-i8h48ny6	328	37	Ca2	ca2	NN
cord-017640-i8h48ny6	328	38	+	+	CC
cord-017640-i8h48ny6	328	39	entry	entry	NN
cord-017640-i8h48ny6	328	40	,	,	,
cord-017640-i8h48ny6	328	41	regulates	regulate	VBZ
cord-017640-i8h48ny6	328	42	recruitment	recruitment	NN
cord-017640-i8h48ny6	328	43	of	of	IN
cord-017640-i8h48ny6	328	44	protein	protein	NN
cord-017640-i8h48ny6	328	45	kinase	kinase	NN
cord-017640-i8h48ny6	328	46	C	C	NNP
cord-017640-i8h48ny6	328	47	(	(	-LRB-
cord-017640-i8h48ny6	328	48	PKC	PKC	NNP
cord-017640-i8h48ny6	328	49	)	)	-RRB-
cord-017640-i8h48ny6	328	50	beta2	beta2	NN
cord-017640-i8h48ny6	328	51	,	,	,
cord-017640-i8h48ny6	328	52	and	and	CC
cord-017640-i8h48ny6	328	53	prevents	prevent	VBZ
cord-017640-i8h48ny6	328	54	death	death	NN
cord-017640-i8h48ny6	328	55	-	-	HYPH
cord-017640-i8h48ny6	328	56	inducing	induce	VBG
cord-017640-i8h48ny6	328	57	signaling	signal	VBG
cord-017640-i8h48ny6	328	58	complex	complex	JJ
cord-017640-i8h48ny6	328	59	formation	formation	NN
cord-017640-i8h48ny6	329	1	The	the	DT
cord-017640-i8h48ny6	329	2	CD95	CD95	NNP
cord-017640-i8h48ny6	329	3	signaling	signal	VBG
cord-017640-i8h48ny6	329	4	pathway	pathway	NN
cord-017640-i8h48ny6	329	5	:	:	:
cord-017640-i8h48ny6	329	6	to	to	TO
cord-017640-i8h48ny6	329	7	not	not	RB
cord-017640-i8h48ny6	329	8	die	die	VB
cord-017640-i8h48ny6	329	9	and	and	CC
cord-017640-i8h48ny6	329	10	fly	fly	VB
cord-017640-i8h48ny6	329	11	RIP	RIP	NNP
cord-017640-i8h48ny6	329	12	:	:	:
cord-017640-i8h48ny6	329	13	a	a	DT
cord-017640-i8h48ny6	329	14	novel	novel	JJ
cord-017640-i8h48ny6	329	15	protein	protein	NN
cord-017640-i8h48ny6	329	16	containing	contain	VBG
cord-017640-i8h48ny6	329	17	a	a	DT
cord-017640-i8h48ny6	329	18	death	death	NN
cord-017640-i8h48ny6	329	19	domain	domain	NN
cord-017640-i8h48ny6	329	20	that	that	WDT
cord-017640-i8h48ny6	329	21	interacts	interact	VBZ
cord-017640-i8h48ny6	329	22	with	with	IN
cord-017640-i8h48ny6	329	23	Fas	Fas	NNP
cord-017640-i8h48ny6	329	24	/	/	SYM
cord-017640-i8h48ny6	329	25	APO-1	APO-1	NNP
cord-017640-i8h48ny6	329	26	(	(	-LRB-
cord-017640-i8h48ny6	329	27	CD95	CD95	NNP
cord-017640-i8h48ny6	329	28	)	)	-RRB-
cord-017640-i8h48ny6	329	29	in	in	IN
cord-017640-i8h48ny6	329	30	yeast	yeast	NN
cord-017640-i8h48ny6	329	31	and	and	CC
cord-017640-i8h48ny6	329	32	causes	cause	VBZ
cord-017640-i8h48ny6	329	33	cell	cell	NN
cord-017640-i8h48ny6	329	34	death	death	NN
cord-017640-i8h48ny6	329	35	Chemical	Chemical	NNP
cord-017640-i8h48ny6	329	36	inhibitor	inhibitor	NN
cord-017640-i8h48ny6	329	37	of	of	IN
cord-017640-i8h48ny6	329	38	nonapoptotic	nonapoptotic	JJ
cord-017640-i8h48ny6	329	39	cell	cell	NN
cord-017640-i8h48ny6	329	40	death	death	NN
cord-017640-i8h48ny6	329	41	with	with	IN
cord-017640-i8h48ny6	329	42	therapeutic	therapeutic	JJ
cord-017640-i8h48ny6	329	43	potential	potential	NN
cord-017640-i8h48ny6	329	44	for	for	IN
cord-017640-i8h48ny6	329	45	ischemic	ischemic	JJ
cord-017640-i8h48ny6	329	46	brain	brain	NN
cord-017640-i8h48ny6	329	47	injury	injury	NN
cord-017640-i8h48ny6	329	48	Identification	identification	NN
cord-017640-i8h48ny6	329	49	of	of	IN
cord-017640-i8h48ny6	329	50	RIP1	RIP1	NNP
cord-017640-i8h48ny6	329	51	kinase	kinase	NNS
cord-017640-i8h48ny6	329	52	as	as	IN
cord-017640-i8h48ny6	329	53	a	a	DT
cord-017640-i8h48ny6	329	54	specific	specific	JJ
cord-017640-i8h48ny6	329	55	cellular	cellular	JJ
cord-017640-i8h48ny6	329	56	target	target	NN
cord-017640-i8h48ny6	329	57	of	of	IN
cord-017640-i8h48ny6	329	58	necrostatins	necrostatins	NNP
cord-017640-i8h48ny6	330	1	The	the	DT
cord-017640-i8h48ny6	330	2	roles	role	NNS
cord-017640-i8h48ny6	330	3	of	of	IN
cord-017640-i8h48ny6	330	4	FADD	FADD	NNP
cord-017640-i8h48ny6	330	5	in	in	IN
cord-017640-i8h48ny6	330	6	extrinsic	extrinsic	JJ
cord-017640-i8h48ny6	330	7	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	330	8	and	and	CC
cord-017640-i8h48ny6	330	9	necroptosis	necroptosis	NN
cord-017640-i8h48ny6	330	10	Cleavage	cleavage	NN
cord-017640-i8h48ny6	330	11	of	of	IN
cord-017640-i8h48ny6	330	12	the	the	DT
cord-017640-i8h48ny6	330	13	death	death	NN
cord-017640-i8h48ny6	330	14	domain	domain	NN
cord-017640-i8h48ny6	330	15	kinase	kinase	NN
cord-017640-i8h48ny6	330	16	RIP	RIP	NNP
cord-017640-i8h48ny6	330	17	by	by	IN
cord-017640-i8h48ny6	330	18	caspase-8	caspase-8	NNP
cord-017640-i8h48ny6	330	19	prompts	prompt	NNS
cord-017640-i8h48ny6	331	1	TNF	TNF	NNP
cord-017640-i8h48ny6	331	2	-	-	HYPH
cord-017640-i8h48ny6	331	3	induced	induce	VBN
cord-017640-i8h48ny6	331	4	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	331	5	Cleavage	cleavage	NN
cord-017640-i8h48ny6	331	6	of	of	IN
cord-017640-i8h48ny6	331	7	RIP3	RIP3	NNP
cord-017640-i8h48ny6	331	8	inactivates	inactivate	VBZ
cord-017640-i8h48ny6	331	9	its	-PRON-	PRP$
cord-017640-i8h48ny6	331	10	caspase	caspase	NN
cord-017640-i8h48ny6	331	11	-	-	HYPH
cord-017640-i8h48ny6	331	12	independent	independent	JJ
cord-017640-i8h48ny6	331	13	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	331	14	pathway	pathway	NN
cord-017640-i8h48ny6	331	15	by	by	IN
cord-017640-i8h48ny6	331	16	removal	removal	NN
cord-017640-i8h48ny6	331	17	of	of	IN
cord-017640-i8h48ny6	331	18	kinase	kinase	NN
cord-017640-i8h48ny6	331	19	domain	domain	NN
cord-017640-i8h48ny6	331	20	Caspase	Caspase	NNP
cord-017640-i8h48ny6	331	21	8	8	CD
cord-017640-i8h48ny6	332	1	inhibits	inhibit	NNS
cord-017640-i8h48ny6	332	2	programmed	programmed	JJ
cord-017640-i8h48ny6	332	3	necrosis	necrosis	NN
cord-017640-i8h48ny6	332	4	by	by	IN
cord-017640-i8h48ny6	332	5	processing	process	VBG
cord-017640-i8h48ny6	332	6	CYLD	CYLD	NNP
cord-017640-i8h48ny6	332	7	Programmed	program	VBD
cord-017640-i8h48ny6	332	8	cell	cell	NN
cord-017640-i8h48ny6	332	9	death	death	NN
cord-017640-i8h48ny6	332	10	:	:	:
cord-017640-i8h48ny6	332	11	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	332	12	meets	meet	VBZ
cord-017640-i8h48ny6	332	13	necrosis	necrosis	NN
cord-017640-i8h48ny6	332	14	Fas	Fas	NNP
cord-017640-i8h48ny6	332	15	involvement	involvement	NN
cord-017640-i8h48ny6	332	16	in	in	IN
cord-017640-i8h48ny6	332	17	cytotoxicity	cytotoxicity	NN
cord-017640-i8h48ny6	332	18	mediated	mediate	VBN
cord-017640-i8h48ny6	332	19	by	by	IN
cord-017640-i8h48ny6	332	20	human	human	JJ
cord-017640-i8h48ny6	332	21	NK	NK	NNP
cord-017640-i8h48ny6	332	22	cells	cell	NNS
cord-017640-i8h48ny6	332	23	Fas	Fas	NNP
cord-017640-i8h48ny6	332	24	ligand	ligand	NN
cord-017640-i8h48ny6	332	25	expression	expression	NN
cord-017640-i8h48ny6	332	26	by	by	IN
cord-017640-i8h48ny6	332	27	astrocytoma	astrocytoma	NN
cord-017640-i8h48ny6	332	28	in	in	IN
cord-017640-i8h48ny6	332	29	vivo	vivo	NN
cord-017640-i8h48ny6	332	30	:	:	:
cord-017640-i8h48ny6	332	31	maintaining	maintain	VBG
cord-017640-i8h48ny6	332	32	immune	immune	JJ
cord-017640-i8h48ny6	332	33	privilege	privilege	NN
cord-017640-i8h48ny6	332	34	in	in	IN
cord-017640-i8h48ny6	332	35	the	the	DT
cord-017640-i8h48ny6	332	36	brain	brain	NN
cord-017640-i8h48ny6	332	37	?	?	.
cord-017640-i8h48ny6	333	1	CD95	CD95	NNP
cord-017640-i8h48ny6	333	2	ligand	ligand	NN
cord-017640-i8h48ny6	333	3	(	(	-LRB-
cord-017640-i8h48ny6	333	4	FasL)-induced	fasl)-induce	VBN
cord-017640-i8h48ny6	333	5	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	333	6	is	be	VBZ
cord-017640-i8h48ny6	333	7	necessary	necessary	JJ
cord-017640-i8h48ny6	333	8	for	for	IN
cord-017640-i8h48ny6	333	9	corneal	corneal	JJ
cord-017640-i8h48ny6	333	10	allograft	allograft	NN
cord-017640-i8h48ny6	333	11	survival	survival	NN
cord-017640-i8h48ny6	333	12	Melanoma	Melanoma	NNP
cord-017640-i8h48ny6	333	13	cell	cell	NN
cord-017640-i8h48ny6	333	14	expression	expression	NN
cord-017640-i8h48ny6	333	15	of	of	IN
cord-017640-i8h48ny6	333	16	Fas(Apo-1	Fas(Apo-1	NNP
cord-017640-i8h48ny6	333	17	/	/	SYM
cord-017640-i8h48ny6	333	18	CD95	CD95	NNP
cord-017640-i8h48ny6	333	19	)	)	-RRB-
cord-017640-i8h48ny6	333	20	ligand	ligand	NN
cord-017640-i8h48ny6	333	21	:	:	:
cord-017640-i8h48ny6	333	22	implications	implication	NNS
cord-017640-i8h48ny6	333	23	for	for	IN
cord-017640-i8h48ny6	333	24	tumor	tumor	NN
cord-017640-i8h48ny6	333	25	immune	immune	JJ
cord-017640-i8h48ny6	333	26	escape	escape	NN
cord-017640-i8h48ny6	334	1	The	the	DT
cord-017640-i8h48ny6	334	2	Fas	Fas	NNP
cord-017640-i8h48ny6	334	3	counterattack	counterattack	NN
cord-017640-i8h48ny6	334	4	:	:	:
cord-017640-i8h48ny6	334	5	Fasmediated	Fasmediated	NNP
cord-017640-i8h48ny6	334	6	T	T	NNP
cord-017640-i8h48ny6	334	7	cell	cell	NN
cord-017640-i8h48ny6	334	8	killing	kill	VBG
cord-017640-i8h48ny6	334	9	by	by	IN
cord-017640-i8h48ny6	334	10	colon	colon	NN
cord-017640-i8h48ny6	334	11	cancer	cancer	NN
cord-017640-i8h48ny6	334	12	cells	cell	NNS
cord-017640-i8h48ny6	334	13	expressing	express	VBG
cord-017640-i8h48ny6	334	14	Fas	Fas	NNP
cord-017640-i8h48ny6	334	15	ligand	ligand	NN
cord-017640-i8h48ny6	334	16	Transgenic	transgenic	JJ
cord-017640-i8h48ny6	334	17	expression	expression	NN
cord-017640-i8h48ny6	334	18	of	of	IN
cord-017640-i8h48ny6	334	19	CD95	CD95	NNP
cord-017640-i8h48ny6	334	20	ligand	ligand	NN
cord-017640-i8h48ny6	334	21	on	on	IN
cord-017640-i8h48ny6	334	22	islet	islet	NN
cord-017640-i8h48ny6	335	1	beta	beta	NN
cord-017640-i8h48ny6	335	2	cells	cell	NNS
cord-017640-i8h48ny6	335	3	induces	induce	VBZ
cord-017640-i8h48ny6	335	4	a	a	DT
cord-017640-i8h48ny6	335	5	granulocytic	granulocytic	JJ
cord-017640-i8h48ny6	335	6	infiltration	infiltration	NN
cord-017640-i8h48ny6	335	7	but	but	CC
cord-017640-i8h48ny6	335	8	does	do	VBZ
cord-017640-i8h48ny6	335	9	not	not	RB
cord-017640-i8h48ny6	335	10	confer	confer	VB
cord-017640-i8h48ny6	335	11	immune	immune	JJ
cord-017640-i8h48ny6	335	12	privilege	privilege	NN
cord-017640-i8h48ny6	335	13	upon	upon	IN
cord-017640-i8h48ny6	335	14	islet	islet	NN
cord-017640-i8h48ny6	335	15	allografts	allografts	NNP
cord-017640-i8h48ny6	335	16	Fas	Fas	NNP
cord-017640-i8h48ny6	335	17	ligand	ligand	NN
cord-017640-i8h48ny6	335	18	expression	expression	NN
cord-017640-i8h48ny6	335	19	in	in	IN
cord-017640-i8h48ny6	335	20	islets	islet	NNS
cord-017640-i8h48ny6	335	21	of	of	IN
cord-017640-i8h48ny6	335	22	Langerhans	Langerhans	NNP
cord-017640-i8h48ny6	335	23	does	do	VBZ
cord-017640-i8h48ny6	335	24	not	not	RB
cord-017640-i8h48ny6	335	25	confer	confer	VB
cord-017640-i8h48ny6	335	26	immune	immune	JJ
cord-017640-i8h48ny6	335	27	privilege	privilege	NN
cord-017640-i8h48ny6	335	28	and	and	CC
cord-017640-i8h48ny6	335	29	instead	instead	RB
cord-017640-i8h48ny6	335	30	targets	target	VBZ
cord-017640-i8h48ny6	335	31	them	-PRON-	PRP
cord-017640-i8h48ny6	335	32	for	for	IN
cord-017640-i8h48ny6	335	33	rapid	rapid	JJ
cord-017640-i8h48ny6	335	34	destruction	destruction	NN
cord-017640-i8h48ny6	335	35	Regulation	regulation	NN
cord-017640-i8h48ny6	335	36	of	of	IN
cord-017640-i8h48ny6	335	37	the	the	DT
cord-017640-i8h48ny6	335	38	proinflammatory	proinflammatory	JJ
cord-017640-i8h48ny6	335	39	effects	effect	NNS
cord-017640-i8h48ny6	335	40	of	of	IN
cord-017640-i8h48ny6	335	41	Fas	Fas	NNP
cord-017640-i8h48ny6	335	42	ligand	ligand	NN
cord-017640-i8h48ny6	335	43	(	(	-LRB-
cord-017640-i8h48ny6	335	44	CD95L	cd95l	NN
cord-017640-i8h48ny6	335	45	)	)	-RRB-
cord-017640-i8h48ny6	336	1	Cancer	cancer	NN
cord-017640-i8h48ny6	336	2	immunosurveillance	immunosurveillance	NN
cord-017640-i8h48ny6	336	3	,	,	,
cord-017640-i8h48ny6	336	4	immunoediting	immunoediting	NN
cord-017640-i8h48ny6	336	5	and	and	CC
cord-017640-i8h48ny6	336	6	inflammation	inflammation	NN
cord-017640-i8h48ny6	336	7	:	:	:
cord-017640-i8h48ny6	336	8	independent	independent	JJ
cord-017640-i8h48ny6	336	9	or	or	CC
cord-017640-i8h48ny6	336	10	interdependent	interdependent	JJ
cord-017640-i8h48ny6	336	11	processes	process	NNS
cord-017640-i8h48ny6	336	12	?	?	.
cord-017640-i8h48ny6	337	1	Dominant	dominant	JJ
cord-017640-i8h48ny6	337	2	-	-	HYPH
cord-017640-i8h48ny6	337	3	negative	negative	JJ
cord-017640-i8h48ny6	337	4	Fas	Fas	NNP
cord-017640-i8h48ny6	337	5	mutation	mutation	NN
cord-017640-i8h48ny6	337	6	is	be	VBZ
cord-017640-i8h48ny6	337	7	reversed	reverse	VBN
cord-017640-i8h48ny6	337	8	by	by	IN
cord-017640-i8h48ny6	337	9	down	down	NN
cord-017640-i8h48ny6	337	10	-	-	HYPH
cord-017640-i8h48ny6	337	11	expression	expression	NN
cord-017640-i8h48ny6	337	12	of	of	IN
cord-017640-i8h48ny6	337	13	c	c	NN
cord-017640-i8h48ny6	337	14	-	-	:
cord-017640-i8h48ny6	337	15	FLIP	FLIP	NNP
cord-017640-i8h48ny6	337	16	CD95	CD95	NNP
cord-017640-i8h48ny6	337	17	promotes	promote	VBZ
cord-017640-i8h48ny6	337	18	tumour	tumour	NN
cord-017640-i8h48ny6	337	19	growth	growth	NN
cord-017640-i8h48ny6	338	1	Yes	yes	UH
cord-017640-i8h48ny6	338	2	and	and	CC
cord-017640-i8h48ny6	338	3	PI3	pi3	NN
cord-017640-i8h48ny6	338	4	K	K	NNP
cord-017640-i8h48ny6	338	5	bind	bind	VB
cord-017640-i8h48ny6	338	6	CD95	CD95	NNP
cord-017640-i8h48ny6	338	7	to	to	TO
cord-017640-i8h48ny6	338	8	signal	signal	VB
cord-017640-i8h48ny6	338	9	invasion	invasion	NN
cord-017640-i8h48ny6	338	10	of	of	IN
cord-017640-i8h48ny6	338	11	glioblastoma	glioblastoma	NN
cord-017640-i8h48ny6	338	12	Stromelysin-1	Stromelysin-1	NNP
cord-017640-i8h48ny6	339	1	(	(	-LRB-
cord-017640-i8h48ny6	339	2	MMP-3	MMP-3	NNP
cord-017640-i8h48ny6	339	3	)	)	-RRB-
cord-017640-i8h48ny6	339	4	in	in	IN
cord-017640-i8h48ny6	339	5	synovial	synovial	JJ
cord-017640-i8h48ny6	339	6	fluid	fluid	NN
cord-017640-i8h48ny6	339	7	of	of	IN
cord-017640-i8h48ny6	339	8	patients	patient	NNS
cord-017640-i8h48ny6	339	9	with	with	IN
cord-017640-i8h48ny6	339	10	rheumatoid	rheumatoid	NN
cord-017640-i8h48ny6	339	11	arthritis	arthritis	NN
cord-017640-i8h48ny6	339	12	has	have	VBZ
cord-017640-i8h48ny6	339	13	potential	potential	NN
cord-017640-i8h48ny6	339	14	to	to	TO
cord-017640-i8h48ny6	339	15	cleave	cleave	VB
cord-017640-i8h48ny6	339	16	membrane	membrane	NN
cord-017640-i8h48ny6	339	17	bound	bind	VBN
cord-017640-i8h48ny6	339	18	Fas	Fas	NNP
cord-017640-i8h48ny6	339	19	ligand	ligand	NN
cord-017640-i8h48ny6	339	20	Identification	identification	NN
cord-017640-i8h48ny6	339	21	of	of	IN
cord-017640-i8h48ny6	339	22	novel	novel	NN
cord-017640-i8h48ny6	339	23	matrix	matrix	NN
cord-017640-i8h48ny6	339	24	metalloproteinase-7	metalloproteinase-7	NNP
cord-017640-i8h48ny6	340	1	(	(	-LRB-
cord-017640-i8h48ny6	340	2	matrilysin	matrilysin	NNP
cord-017640-i8h48ny6	340	3	)	)	-RRB-
cord-017640-i8h48ny6	340	4	cleavage	cleavage	NN
cord-017640-i8h48ny6	340	5	sites	site	NNS
cord-017640-i8h48ny6	340	6	in	in	IN
cord-017640-i8h48ny6	340	7	murine	murine	JJ
cord-017640-i8h48ny6	340	8	and	and	CC
cord-017640-i8h48ny6	340	9	human	human	JJ
cord-017640-i8h48ny6	340	10	Fas	Fas	NNP
cord-017640-i8h48ny6	340	11	ligand	ligand	NN
cord-017640-i8h48ny6	340	12	Matrix	Matrix	NNP
cord-017640-i8h48ny6	340	13	metalloproteinase-9	metalloproteinase-9	NNP
cord-017640-i8h48ny6	340	14	regulates	regulate	VBZ
cord-017640-i8h48ny6	340	15	TNF	TNF	NNP
cord-017640-i8h48ny6	340	16	-	-	HYPH
cord-017640-i8h48ny6	340	17	alpha	alpha	NN
cord-017640-i8h48ny6	340	18	and	and	CC
cord-017640-i8h48ny6	340	19	FasL	FasL	NNP
cord-017640-i8h48ny6	340	20	expression	expression	NN
cord-017640-i8h48ny6	340	21	in	in	IN
cord-017640-i8h48ny6	340	22	neuronal	neuronal	JJ
cord-017640-i8h48ny6	340	23	,	,	,
cord-017640-i8h48ny6	340	24	glial	glial	JJ
cord-017640-i8h48ny6	340	25	cells	cell	NNS
cord-017640-i8h48ny6	340	26	and	and	CC
cord-017640-i8h48ny6	340	27	its	-PRON-	PRP$
cord-017640-i8h48ny6	340	28	absence	absence	NN
cord-017640-i8h48ny6	340	29	extends	extend	VBZ
cord-017640-i8h48ny6	340	30	life	life	NN
cord-017640-i8h48ny6	340	31	in	in	IN
cord-017640-i8h48ny6	340	32	a	a	DT
cord-017640-i8h48ny6	340	33	transgenic	transgenic	JJ
cord-017640-i8h48ny6	340	34	mouse	mouse	NN
cord-017640-i8h48ny6	340	35	model	model	NN
cord-017640-i8h48ny6	340	36	of	of	IN
cord-017640-i8h48ny6	340	37	amyotrophic	amyotrophic	JJ
cord-017640-i8h48ny6	340	38	lateral	lateral	JJ
cord-017640-i8h48ny6	340	39	sclerosis	sclerosis	NN
cord-017640-i8h48ny6	341	1	The	the	DT
cord-017640-i8h48ny6	341	2	Fas	Fas	NNP
cord-017640-i8h48ny6	341	3	ligand	ligand	NN
cord-017640-i8h48ny6	341	4	intracellular	intracellular	JJ
cord-017640-i8h48ny6	341	5	domain	domain	NN
cord-017640-i8h48ny6	341	6	is	be	VBZ
cord-017640-i8h48ny6	341	7	released	release	VBN
cord-017640-i8h48ny6	341	8	by	by	IN
cord-017640-i8h48ny6	341	9	ADAM10	adam10	NN
cord-017640-i8h48ny6	341	10	and	and	CC
cord-017640-i8h48ny6	341	11	SPPL2a	sppl2a	JJ
cord-017640-i8h48ny6	341	12	cleavage	cleavage	NN
cord-017640-i8h48ny6	341	13	in	in	IN
cord-017640-i8h48ny6	341	14	T	t	NN
cord-017640-i8h48ny6	341	15	-	-	HYPH
cord-017640-i8h48ny6	341	16	cells	cell	NNS
cord-017640-i8h48ny6	342	1	ADAM10	ADAM10	NNP
cord-017640-i8h48ny6	342	2	regulates	regulate	VBZ
cord-017640-i8h48ny6	342	3	FasL	FasL	NNP
cord-017640-i8h48ny6	342	4	cell	cell	NN
cord-017640-i8h48ny6	342	5	surface	surface	NN
cord-017640-i8h48ny6	342	6	expression	expression	NN
cord-017640-i8h48ny6	342	7	and	and	CC
cord-017640-i8h48ny6	342	8	modulates	modulate	VBZ
cord-017640-i8h48ny6	342	9	FasL	FasL	NNP
cord-017640-i8h48ny6	342	10	-	-	HYPH
cord-017640-i8h48ny6	342	11	induced	induce	VBN
cord-017640-i8h48ny6	342	12	cytotoxicity	cytotoxicity	NN
cord-017640-i8h48ny6	342	13	and	and	CC
cord-017640-i8h48ny6	342	14	activation	activation	NN
cord-017640-i8h48ny6	342	15	-	-	HYPH
cord-017640-i8h48ny6	342	16	induced	induce	VBN
cord-017640-i8h48ny6	342	17	cell	cell	NN
cord-017640-i8h48ny6	342	18	death	death	NN
cord-017640-i8h48ny6	343	1	Two	two	CD
cord-017640-i8h48ny6	343	2	adjacent	adjacent	JJ
cord-017640-i8h48ny6	343	3	trimeric	trimeric	NNP
cord-017640-i8h48ny6	344	1	Fas	Fas	NNP
cord-017640-i8h48ny6	344	2	ligands	ligand	NNS
cord-017640-i8h48ny6	344	3	are	be	VBP
cord-017640-i8h48ny6	344	4	required	require	VBN
cord-017640-i8h48ny6	344	5	for	for	IN
cord-017640-i8h48ny6	344	6	Fas	Fas	NNP
cord-017640-i8h48ny6	344	7	signaling	signaling	NN
cord-017640-i8h48ny6	344	8	and	and	CC
cord-017640-i8h48ny6	344	9	formation	formation	NN
cord-017640-i8h48ny6	344	10	of	of	IN
cord-017640-i8h48ny6	344	11	a	a	DT
cord-017640-i8h48ny6	344	12	death	death	NN
cord-017640-i8h48ny6	344	13	-	-	HYPH
cord-017640-i8h48ny6	344	14	inducing	induce	VBG
cord-017640-i8h48ny6	344	15	signaling	signal	VBG
cord-017640-i8h48ny6	344	16	complex	complex	JJ
cord-017640-i8h48ny6	344	17	Conversion	conversion	NN
cord-017640-i8h48ny6	344	18	of	of	IN
cord-017640-i8h48ny6	344	19	membranebound	membranebound	NNP
cord-017640-i8h48ny6	344	20	Fas(CD95	Fas(CD95	NNP
cord-017640-i8h48ny6	344	21	)	)	-RRB-
cord-017640-i8h48ny6	344	22	ligand	ligand	NN
cord-017640-i8h48ny6	344	23	to	to	IN
cord-017640-i8h48ny6	344	24	its	-PRON-	PRP$
cord-017640-i8h48ny6	344	25	soluble	soluble	JJ
cord-017640-i8h48ny6	344	26	form	form	NN
cord-017640-i8h48ny6	344	27	is	be	VBZ
cord-017640-i8h48ny6	344	28	associated	associate	VBN
cord-017640-i8h48ny6	344	29	with	with	IN
cord-017640-i8h48ny6	344	30	downregulation	downregulation	NN
cord-017640-i8h48ny6	344	31	of	of	IN
cord-017640-i8h48ny6	344	32	its	-PRON-	PRP$
cord-017640-i8h48ny6	344	33	proapoptotic	proapoptotic	JJ
cord-017640-i8h48ny6	344	34	activity	activity	NN
cord-017640-i8h48ny6	344	35	and	and	CC
cord-017640-i8h48ny6	344	36	loss	loss	NN
cord-017640-i8h48ny6	344	37	of	of	IN
cord-017640-i8h48ny6	344	38	liver	liver	NN
cord-017640-i8h48ny6	344	39	toxicity	toxicity	NN
cord-017640-i8h48ny6	344	40	Membrane	membrane	NN
cord-017640-i8h48ny6	344	41	Fas	Fas	NNP
cord-017640-i8h48ny6	344	42	ligand	ligand	NN
cord-017640-i8h48ny6	344	43	kills	kill	VBZ
cord-017640-i8h48ny6	344	44	human	human	JJ
cord-017640-i8h48ny6	344	45	peripheral	peripheral	JJ
cord-017640-i8h48ny6	344	46	blood	blood	NN
cord-017640-i8h48ny6	344	47	T	t	NN
cord-017640-i8h48ny6	344	48	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	344	49	,	,	,
cord-017640-i8h48ny6	344	50	and	and	CC
cord-017640-i8h48ny6	344	51	soluble	soluble	JJ
cord-017640-i8h48ny6	344	52	Fas	Fas	NNP
cord-017640-i8h48ny6	344	53	ligand	ligand	NN
cord-017640-i8h48ny6	344	54	blocks	block	VBZ
cord-017640-i8h48ny6	344	55	the	the	DT
cord-017640-i8h48ny6	344	56	killing	killing	NN
cord-017640-i8h48ny6	344	57	CD95L	cd95l	NN
cord-017640-i8h48ny6	344	58	cell	cell	NN
cord-017640-i8h48ny6	344	59	surface	surface	NN
cord-017640-i8h48ny6	344	60	cleavage	cleavage	NN
cord-017640-i8h48ny6	344	61	triggers	trigger	VBZ
cord-017640-i8h48ny6	344	62	a	a	DT
cord-017640-i8h48ny6	344	63	pro	pro	JJ
cord-017640-i8h48ny6	344	64	-	-	JJ
cord-017640-i8h48ny6	344	65	metastatic	metastatic	JJ
cord-017640-i8h48ny6	344	66	signaling	signal	VBG
cord-017640-i8h48ny6	344	67	pathway	pathway	NN
cord-017640-i8h48ny6	344	68	in	in	IN
cord-017640-i8h48ny6	344	69	triple	triple	JJ
cord-017640-i8h48ny6	344	70	negative	negative	JJ
cord-017640-i8h48ny6	344	71	breast	breast	NN
cord-017640-i8h48ny6	344	72	cancer	cancer	NN
cord-017640-i8h48ny6	344	73	Src	Src	NNP
cord-017640-i8h48ny6	344	74	kinase	kinase	NN
cord-017640-i8h48ny6	344	75	phosphorylates	phosphorylate	VBZ
cord-017640-i8h48ny6	344	76	Caspase-8	Caspase-8	NNP
cord-017640-i8h48ny6	344	77	on	on	IN
cord-017640-i8h48ny6	344	78	Tyr380	tyr380	CD
cord-017640-i8h48ny6	344	79	:	:	:
cord-017640-i8h48ny6	344	80	a	a	DT
cord-017640-i8h48ny6	344	81	novel	novel	JJ
cord-017640-i8h48ny6	344	82	mechanism	mechanism	NN
cord-017640-i8h48ny6	344	83	of	of	IN
cord-017640-i8h48ny6	344	84	apoptosis	apoptosis	NN
cord-017640-i8h48ny6	344	85	suppression	suppression	NN
cord-017640-i8h48ny6	344	86	Caspase-8	Caspase-8	NNP
cord-017640-i8h48ny6	344	87	interacts	interact	VBZ
cord-017640-i8h48ny6	344	88	with	with	IN
cord-017640-i8h48ny6	344	89	the	the	DT
cord-017640-i8h48ny6	344	90	p85	p85	NN
cord-017640-i8h48ny6	344	91	subunit	subunit	NN
cord-017640-i8h48ny6	344	92	of	of	IN
cord-017640-i8h48ny6	344	93	phosphatidylinositol	phosphatidylinositol	JJ
cord-017640-i8h48ny6	344	94	3-kinase	3-kinase	CD
cord-017640-i8h48ny6	344	95	to	to	TO
cord-017640-i8h48ny6	344	96	regulate	regulate	VB
cord-017640-i8h48ny6	344	97	cell	cell	NN
cord-017640-i8h48ny6	344	98	adhesion	adhesion	NN
cord-017640-i8h48ny6	344	99	and	and	CC
cord-017640-i8h48ny6	344	100	motility	motility	NN
cord-017640-i8h48ny6	344	101	How	how	WRB
cord-017640-i8h48ny6	344	102	CD95	CD95	NNP
cord-017640-i8h48ny6	344	103	stimulates	stimulate	VBZ
cord-017640-i8h48ny6	344	104	invasion	invasion	NN
cord-017640-i8h48ny6	344	105	FAS	FAS	NNP
cord-017640-i8h48ny6	344	106	and	and	CC
cord-017640-i8h48ny6	344	107	NF	NF	NNP
cord-017640-i8h48ny6	344	108	-	-	HYPH
cord-017640-i8h48ny6	344	109	kappaB	kappaB	NNP
cord-017640-i8h48ny6	344	110	signalling	signalling	NN
cord-017640-i8h48ny6	344	111	modulate	modulate	VBP
cord-017640-i8h48ny6	344	112	dependence	dependence	NN
cord-017640-i8h48ny6	344	113	of	of	IN
cord-017640-i8h48ny6	344	114	lung	lung	NN
cord-017640-i8h48ny6	344	115	cancers	cancer	NNS
cord-017640-i8h48ny6	344	116	on	on	IN
cord-017640-i8h48ny6	344	117	mutant	mutant	JJ
cord-017640-i8h48ny6	344	118	EGFR	EGFR	NNP
cord-017640-i8h48ny6	344	119	Production	Production	NNP
cord-017640-i8h48ny6	344	120	and	and	CC
cord-017640-i8h48ny6	344	121	pro	pro	JJ
cord-017640-i8h48ny6	344	122	-	-	JJ
cord-017640-i8h48ny6	344	123	apoptotic	apoptotic	JJ
cord-017640-i8h48ny6	344	124	activity	activity	NN
cord-017640-i8h48ny6	344	125	of	of	IN
cord-017640-i8h48ny6	344	126	soluble	soluble	JJ
cord-017640-i8h48ny6	344	127	CD95	CD95	NNP
cord-017640-i8h48ny6	344	128	ligand	ligand	NN
cord-017640-i8h48ny6	344	129	in	in	IN
cord-017640-i8h48ny6	344	130	pancreatic	pancreatic	JJ
cord-017640-i8h48ny6	344	131	carcinoma	carcinoma	NN
cord-017640-i8h48ny6	344	132	Fas	Fas	NNP
cord-017640-i8h48ny6	344	133	ligand	ligand	NN
cord-017640-i8h48ny6	344	134	in	in	IN
cord-017640-i8h48ny6	344	135	human	human	JJ
cord-017640-i8h48ny6	344	136	serum	serum	NN
cord-017640-i8h48ny6	344	137	Soluble	Soluble	NNP
cord-017640-i8h48ny6	344	138	Fas	Fas	NNP
cord-017640-i8h48ny6	344	139	ligand	ligand	NN
cord-017640-i8h48ny6	344	140	in	in	IN
cord-017640-i8h48ny6	344	141	the	the	DT
cord-017640-i8h48ny6	344	142	joints	joint	NNS
cord-017640-i8h48ny6	344	143	of	of	IN
cord-017640-i8h48ny6	344	144	patients	patient	NNS
cord-017640-i8h48ny6	344	145	with	with	IN
cord-017640-i8h48ny6	344	146	rheumatoid	rheumatoid	NN
cord-017640-i8h48ny6	344	147	arthritis	arthritis	NN
cord-017640-i8h48ny6	344	148	and	and	CC
cord-017640-i8h48ny6	344	149	osteoarthritis	osteoarthritis	NN
cord-017640-i8h48ny6	344	150	Levels	level	NNS
cord-017640-i8h48ny6	344	151	of	of	IN
cord-017640-i8h48ny6	344	152	soluble	soluble	JJ
cord-017640-i8h48ny6	344	153	FasL	FasL	NNP
cord-017640-i8h48ny6	344	154	and	and	CC
cord-017640-i8h48ny6	344	155	FasL	FasL	NNP
cord-017640-i8h48ny6	344	156	gene	gene	NN
cord-017640-i8h48ny6	344	157	expression	expression	NN
cord-017640-i8h48ny6	344	158	during	during	IN
cord-017640-i8h48ny6	344	159	the	the	DT
cord-017640-i8h48ny6	344	160	development	development	NN
cord-017640-i8h48ny6	344	161	of	of	IN
cord-017640-i8h48ny6	344	162	graft	graft	NN
cord-017640-i8h48ny6	344	163	-	-	HYPH
cord-017640-i8h48ny6	344	164	versushost	versushost	NN
cord-017640-i8h48ny6	344	165	disease	disease	NN
cord-017640-i8h48ny6	344	166	in	in	IN
cord-017640-i8h48ny6	344	167	DLT	DLT	NNP
cord-017640-i8h48ny6	344	168	-	-	HYPH
cord-017640-i8h48ny6	344	169	treated	treat	VBN
cord-017640-i8h48ny6	344	170	patients	patient	NNS
cord-017640-i8h48ny6	345	1	Increased	increase	VBN
cord-017640-i8h48ny6	345	2	soluble	soluble	JJ
cord-017640-i8h48ny6	345	3	Fas	Fas	NNP
cord-017640-i8h48ny6	345	4	-	-	HYPH
cord-017640-i8h48ny6	345	5	ligand	ligand	NNP
cord-017640-i8h48ny6	345	6	in	in	IN
cord-017640-i8h48ny6	345	7	sera	sera	NNP
cord-017640-i8h48ny6	345	8	of	of	IN
cord-017640-i8h48ny6	345	9	bone	bone	NN
cord-017640-i8h48ny6	345	10	marrow	marrow	NN
cord-017640-i8h48ny6	345	11	transplant	transplant	NN
cord-017640-i8h48ny6	345	12	recipients	recipient	NNS
cord-017640-i8h48ny6	345	13	with	with	IN
cord-017640-i8h48ny6	345	14	acute	acute	JJ
cord-017640-i8h48ny6	345	15	graft	graft	NN
cord-017640-i8h48ny6	345	16	-	-	HYPH
cord-017640-i8h48ny6	345	17	versus	versus	IN
cord-017640-i8h48ny6	345	18	-	-	HYPH
cord-017640-i8h48ny6	345	19	host	host	NN
cord-017640-i8h48ny6	345	20	disease	disease	NN
cord-017640-i8h48ny6	345	21	Serum	serum	NN
cord-017640-i8h48ny6	345	22	levels	level	NNS
cord-017640-i8h48ny6	345	23	of	of	IN
cord-017640-i8h48ny6	345	24	soluble	soluble	JJ
cord-017640-i8h48ny6	345	25	Fas	Fas	NNP
cord-017640-i8h48ny6	345	26	ligand	ligand	NN
cord-017640-i8h48ny6	345	27	in	in	IN
cord-017640-i8h48ny6	345	28	patients	patient	NNS
cord-017640-i8h48ny6	345	29	with	with	IN
cord-017640-i8h48ny6	345	30	silicosis	silicosis	NN
cord-017640-i8h48ny6	346	1	The	the	DT
cord-017640-i8h48ny6	346	2	biological	biological	JJ
cord-017640-i8h48ny6	346	3	activity	activity	NN
cord-017640-i8h48ny6	346	4	of	of	IN
cord-017640-i8h48ny6	346	5	FasL	FasL	NNP
cord-017640-i8h48ny6	346	6	in	in	IN
cord-017640-i8h48ny6	346	7	human	human	NN
cord-017640-i8h48ny6	346	8	and	and	CC
cord-017640-i8h48ny6	346	9	mouse	mouse	NN
cord-017640-i8h48ny6	346	10	lungs	lung	NNS
cord-017640-i8h48ny6	346	11	is	be	VBZ
cord-017640-i8h48ny6	346	12	determined	determine	VBN
cord-017640-i8h48ny6	346	13	by	by	IN
cord-017640-i8h48ny6	346	14	the	the	DT
cord-017640-i8h48ny6	346	15	structure	structure	NN
cord-017640-i8h48ny6	346	16	of	of	IN
cord-017640-i8h48ny6	346	17	its	-PRON-	PRP$
cord-017640-i8h48ny6	346	18	stalk	stalk	NN
cord-017640-i8h48ny6	346	19	region	region	NN
cord-017640-i8h48ny6	346	20	Diacylglycerol	Diacylglycerol	NNP
cord-017640-i8h48ny6	346	21	kinase	kinase	NN
cord-017640-i8h48ny6	346	22	alpha	alpha	NN
cord-017640-i8h48ny6	346	23	regulates	regulate	VBZ
cord-017640-i8h48ny6	346	24	the	the	DT
cord-017640-i8h48ny6	346	25	formation	formation	NN
cord-017640-i8h48ny6	346	26	and	and	CC
cord-017640-i8h48ny6	346	27	polarisation	polarisation	NN
cord-017640-i8h48ny6	346	28	of	of	IN
cord-017640-i8h48ny6	346	29	mature	mature	JJ
cord-017640-i8h48ny6	346	30	multivesicular	multivesicular	JJ
cord-017640-i8h48ny6	346	31	bodies	body	NNS
cord-017640-i8h48ny6	346	32	involved	involve	VBN
cord-017640-i8h48ny6	346	33	in	in	IN
cord-017640-i8h48ny6	346	34	the	the	DT
cord-017640-i8h48ny6	346	35	secretion	secretion	NN
cord-017640-i8h48ny6	346	36	of	of	IN
cord-017640-i8h48ny6	346	37	Fas	Fas	NNP
cord-017640-i8h48ny6	346	38	ligand	ligand	NN
cord-017640-i8h48ny6	346	39	-	-	HYPH
cord-017640-i8h48ny6	346	40	containing	contain	VBG
cord-017640-i8h48ny6	346	41	exosomes	exosome	NNS
cord-017640-i8h48ny6	346	42	in	in	IN
cord-017640-i8h48ny6	346	43	T	T	NNP
cord-017640-i8h48ny6	346	44	lymphocytes	lymphocyte	NNS
cord-017640-i8h48ny6	346	45	Modulation	modulation	NN
cord-017640-i8h48ny6	346	46	of	of	IN
cord-017640-i8h48ny6	346	47	the	the	DT
cord-017640-i8h48ny6	346	48	immune	immune	JJ
cord-017640-i8h48ny6	346	49	response	response	NN
cord-017640-i8h48ny6	346	50	using	use	VBG
cord-017640-i8h48ny6	346	51	dendritic	dendritic	JJ
cord-017640-i8h48ny6	346	52	cell	cell	NN
cord-017640-i8h48ny6	346	53	-	-	HYPH
cord-017640-i8h48ny6	346	54	derived	derive	VBN
cord-017640-i8h48ny6	346	55	exosomes	exosomes	NNP
cord-017640-i8h48ny6	346	56	Tumor	tumor	NN
cord-017640-i8h48ny6	346	57	exosomes	exosome	NNS
cord-017640-i8h48ny6	346	58	expressing	express	VBG
cord-017640-i8h48ny6	346	59	Fas	Fas	NNP
cord-017640-i8h48ny6	346	60	ligand	ligand	NN
cord-017640-i8h48ny6	346	61	mediate	mediate	VBP
cord-017640-i8h48ny6	346	62	CD8	CD8	NNP
cord-017640-i8h48ny6	346	63	+	+	CC
cord-017640-i8h48ny6	346	64	T	t	NN
cord-017640-i8h48ny6	346	65	-	-	HYPH
cord-017640-i8h48ny6	346	66	cell	cell	NN
cord-017640-i8h48ny6	346	67	apoptosis	apoptosis	NN