id	sid	tid	token	lemma	pos
cord-018764-02l423mk	1	1	key	key	NN
cord-018764-02l423mk	1	2	:	:	:
cord-018764-02l423mk	1	3	cord-018764	cord-018764	NNP
cord-018764-02l423mk	1	4	-	-	HYPH
cord-018764-02l423mk	1	5	02l423mk	02l423mk	NNP
cord-018764-02l423mk	1	6	authors	author	NNS
cord-018764-02l423mk	1	7	:	:	:
cord-018764-02l423mk	1	8	Clark	Clark	NNP
cord-018764-02l423mk	1	9	,	,	,
cord-018764-02l423mk	1	10	Ian	Ian	NNP
cord-018764-02l423mk	1	11	A.	A.	NNP
cord-018764-02l423mk	1	12	;	;	:
cord-018764-02l423mk	1	13	Griffiths	Griffiths	NNP
cord-018764-02l423mk	1	14	,	,	,
cord-018764-02l423mk	1	15	Michael	Michael	NNP
cord-018764-02l423mk	1	16	J.	J.	NNP
cord-018764-02l423mk	1	17	title	title	NN
cord-018764-02l423mk	1	18	:	:	:
cord-018764-02l423mk	2	1	The	the	DT
cord-018764-02l423mk	2	2	molecular	molecular	JJ
cord-018764-02l423mk	2	3	basis	basis	NN
cord-018764-02l423mk	2	4	of	of	IN
cord-018764-02l423mk	2	5	paediatric	paediatric	JJ
cord-018764-02l423mk	2	6	malarial	malarial	JJ
cord-018764-02l423mk	2	7	disease	disease	NN
cord-018764-02l423mk	2	8	date	date	NN
cord-018764-02l423mk	2	9	:	:	:
cord-018764-02l423mk	2	10	2007	2007	CD
cord-018764-02l423mk	2	11	journal	journal	NNP
cord-018764-02l423mk	2	12	:	:	:
cord-018764-02l423mk	3	1	Pediatric	pediatric	JJ
cord-018764-02l423mk	3	2	Infectious	infectious	JJ
cord-018764-02l423mk	3	3	Diseases	Diseases	NNPS
cord-018764-02l423mk	4	1	Revisited	revisit	VBN
cord-018764-02l423mk	5	1	DOI	DOI	NNP
cord-018764-02l423mk	5	2	:	:	:
cord-018764-02l423mk	5	3	10.1007/978	10.1007/978	CD
cord-018764-02l423mk	5	4	-	-	HYPH
cord-018764-02l423mk	5	5	3	3	CD
cord-018764-02l423mk	5	6	-	-	HYPH
cord-018764-02l423mk	5	7	7643	7643	CD
cord-018764-02l423mk	5	8	-	-	HYPH
cord-018764-02l423mk	5	9	8099	8099	CD
cord-018764-02l423mk	5	10	-	-	SYM
cord-018764-02l423mk	5	11	1_9	1_9	CD
cord-018764-02l423mk	5	12	sha	sha	NNP
cord-018764-02l423mk	5	13	:	:	:
cord-018764-02l423mk	6	1	e4b3a3eca98196afdb6a407514afdaa36c951f23	e4b3a3eca98196afdb6a407514afdaa36c951f23	IN
cord-018764-02l423mk	7	1	doc_id	doc_id	CD
cord-018764-02l423mk	7	2	:	:	:
cord-018764-02l423mk	8	1	18764	18764	CD
cord-018764-02l423mk	9	1	cord_uid	cord_uid	NN
cord-018764-02l423mk	9	2	:	:	:
cord-018764-02l423mk	10	1	02l423mk	02l423mk	NNP
cord-018764-02l423mk	10	2	Severe	severe	JJ
cord-018764-02l423mk	10	3	falciparum	falciparum	NNP
cord-018764-02l423mk	11	1	malaria	malaria	NNP
cord-018764-02l423mk	11	2	is	be	VBZ
cord-018764-02l423mk	11	3	an	an	DT
cord-018764-02l423mk	11	4	acute	acute	JJ
cord-018764-02l423mk	11	5	systemic	systemic	JJ
cord-018764-02l423mk	11	6	disease	disease	NN
cord-018764-02l423mk	11	7	that	that	WDT
cord-018764-02l423mk	11	8	can	can	MD
cord-018764-02l423mk	11	9	affect	affect	VB
cord-018764-02l423mk	11	10	multiple	multiple	JJ
cord-018764-02l423mk	11	11	organs	organ	NNS
cord-018764-02l423mk	11	12	,	,	,
cord-018764-02l423mk	11	13	including	include	VBG
cord-018764-02l423mk	11	14	those	those	DT
cord-018764-02l423mk	11	15	in	in	IN
cord-018764-02l423mk	11	16	which	which	WDT
cord-018764-02l423mk	11	17	few	few	JJ
cord-018764-02l423mk	11	18	parasites	parasite	NNS
cord-018764-02l423mk	11	19	are	be	VBP
cord-018764-02l423mk	11	20	found	find	VBN
cord-018764-02l423mk	11	21	.	.	.
cord-018764-02l423mk	12	1	The	the	DT
cord-018764-02l423mk	12	2	acute	acute	JJ
cord-018764-02l423mk	12	3	disease	disease	NN
cord-018764-02l423mk	12	4	bears	bear	VBZ
cord-018764-02l423mk	12	5	many	many	JJ
cord-018764-02l423mk	12	6	similarities	similarity	NNS
cord-018764-02l423mk	12	7	both	both	DT
cord-018764-02l423mk	12	8	clinically	clinically	RB
cord-018764-02l423mk	12	9	and	and	CC
cord-018764-02l423mk	12	10	,	,	,
cord-018764-02l423mk	12	11	potentially	potentially	RB
cord-018764-02l423mk	12	12	,	,	,
cord-018764-02l423mk	12	13	mechanistically	mechanistically	RB
cord-018764-02l423mk	12	14	,	,	,
cord-018764-02l423mk	12	15	to	to	IN
cord-018764-02l423mk	12	16	the	the	DT
cord-018764-02l423mk	12	17	systemic	systemic	JJ
cord-018764-02l423mk	12	18	diseases	disease	NNS
cord-018764-02l423mk	12	19	caused	cause	VBN
cord-018764-02l423mk	12	20	by	by	IN
cord-018764-02l423mk	12	21	bacteria	bacteria	NNS
cord-018764-02l423mk	12	22	,	,	,
cord-018764-02l423mk	12	23	rickettsia	rickettsia	NN
cord-018764-02l423mk	12	24	,	,	,
cord-018764-02l423mk	12	25	and	and	CC
cord-018764-02l423mk	12	26	viruses	virus	NNS
cord-018764-02l423mk	12	27	.	.	.
cord-018764-02l423mk	13	1	Traditionally	traditionally	RB
cord-018764-02l423mk	13	2	the	the	DT
cord-018764-02l423mk	13	3	morbidity	morbidity	NN
cord-018764-02l423mk	13	4	and	and	CC
cord-018764-02l423mk	13	5	mortality	mortality	NN
cord-018764-02l423mk	13	6	associated	associate	VBN
cord-018764-02l423mk	13	7	with	with	IN
cord-018764-02l423mk	13	8	severe	severe	JJ
cord-018764-02l423mk	13	9	malarial	malarial	JJ
cord-018764-02l423mk	13	10	disease	disease	NN
cord-018764-02l423mk	13	11	has	have	VBZ
cord-018764-02l423mk	13	12	been	be	VBN
cord-018764-02l423mk	13	13	explained	explain	VBN
cord-018764-02l423mk	13	14	in	in	IN
cord-018764-02l423mk	13	15	terms	term	NNS
cord-018764-02l423mk	13	16	of	of	IN
cord-018764-02l423mk	13	17	mechanical	mechanical	JJ
cord-018764-02l423mk	13	18	obstruction	obstruction	NN
cord-018764-02l423mk	13	19	to	to	IN
cord-018764-02l423mk	13	20	vascular	vascular	JJ
cord-018764-02l423mk	13	21	flow	flow	NN
cord-018764-02l423mk	13	22	by	by	IN
cord-018764-02l423mk	13	23	adherence	adherence	NN
cord-018764-02l423mk	13	24	to	to	IN
cord-018764-02l423mk	13	25	endothelium	endothelium	NN
cord-018764-02l423mk	13	26	(	(	-LRB-
cord-018764-02l423mk	13	27	termed	term	VBN
cord-018764-02l423mk	13	28	sequestration	sequestration	NN
cord-018764-02l423mk	13	29	)	)	-RRB-
cord-018764-02l423mk	13	30	of	of	IN
cord-018764-02l423mk	13	31	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	13	32	containing	contain	VBG
cord-018764-02l423mk	13	33	mature	mature	JJ
cord-018764-02l423mk	13	34	-	-	HYPH
cord-018764-02l423mk	13	35	stage	stage	NN
cord-018764-02l423mk	13	36	parasites	parasite	NNS
cord-018764-02l423mk	13	37	.	.	.
cord-018764-02l423mk	14	1	However	however	RB
cord-018764-02l423mk	14	2	,	,	,
cord-018764-02l423mk	14	3	over	over	IN
cord-018764-02l423mk	14	4	the	the	DT
cord-018764-02l423mk	14	5	past	past	JJ
cord-018764-02l423mk	14	6	few	few	JJ
cord-018764-02l423mk	14	7	decades	decade	NNS
cord-018764-02l423mk	14	8	an	an	DT
cord-018764-02l423mk	14	9	alternative	alternative	JJ
cord-018764-02l423mk	14	10	‘	'	``
cord-018764-02l423mk	14	11	cytokine	cytokine	NN
cord-018764-02l423mk	14	12	theory	theory	NN
cord-018764-02l423mk	14	13	of	of	IN
cord-018764-02l423mk	14	14	disease	disease	NN
cord-018764-02l423mk	14	15	’	'	''
cord-018764-02l423mk	14	16	has	have	VBZ
cord-018764-02l423mk	14	17	also	also	RB
cord-018764-02l423mk	14	18	evolved	evolve	VBN
cord-018764-02l423mk	14	19	,	,	,
cord-018764-02l423mk	14	20	where	where	WRB
cord-018764-02l423mk	14	21	malarial	malarial	JJ
cord-018764-02l423mk	14	22	pathology	pathology	NN
cord-018764-02l423mk	14	23	is	be	VBZ
cord-018764-02l423mk	14	24	explained	explain	VBN
cord-018764-02l423mk	14	25	in	in	IN
cord-018764-02l423mk	14	26	terms	term	NNS
cord-018764-02l423mk	14	27	of	of	IN
cord-018764-02l423mk	14	28	a	a	DT
cord-018764-02l423mk	14	29	balance	balance	NN
cord-018764-02l423mk	14	30	between	between	IN
cord-018764-02l423mk	14	31	the	the	DT
cord-018764-02l423mk	14	32	pro-	pro-	JJ
cord-018764-02l423mk	14	33	and	and	CC
cord-018764-02l423mk	14	34	anti	anti	JJ
cord-018764-02l423mk	14	35	-	-	JJ
cord-018764-02l423mk	14	36	inflammatory	inflammatory	JJ
cord-018764-02l423mk	14	37	cytokines	cytokine	NNS
cord-018764-02l423mk	14	38	.	.	.
cord-018764-02l423mk	15	1	The	the	DT
cord-018764-02l423mk	15	2	final	final	JJ
cord-018764-02l423mk	15	3	common	common	JJ
cord-018764-02l423mk	15	4	pathway	pathway	NN
cord-018764-02l423mk	15	5	for	for	IN
cord-018764-02l423mk	15	6	this	this	DT
cord-018764-02l423mk	15	7	pro	pro	JJ
cord-018764-02l423mk	15	8	-	-	JJ
cord-018764-02l423mk	15	9	inflammatory	inflammatory	JJ
cord-018764-02l423mk	15	10	imbalance	imbalance	NN
cord-018764-02l423mk	15	11	is	be	VBZ
cord-018764-02l423mk	15	12	believed	believe	VBN
cord-018764-02l423mk	15	13	to	to	TO
cord-018764-02l423mk	15	14	be	be	VB
cord-018764-02l423mk	15	15	a	a	DT
cord-018764-02l423mk	15	16	limitation	limitation	NN
cord-018764-02l423mk	15	17	in	in	IN
cord-018764-02l423mk	15	18	the	the	DT
cord-018764-02l423mk	15	19	supply	supply	NN
cord-018764-02l423mk	15	20	and	and	CC
cord-018764-02l423mk	15	21	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	15	22	utilisation	utilisation	NN
cord-018764-02l423mk	15	23	of	of	IN
cord-018764-02l423mk	15	24	energy	energy	NN
cord-018764-02l423mk	15	25	to	to	IN
cord-018764-02l423mk	15	26	cells	cell	NNS
cord-018764-02l423mk	15	27	.	.	.
cord-018764-02l423mk	16	1	Different	different	JJ
cord-018764-02l423mk	16	2	patterns	pattern	NNS
cord-018764-02l423mk	16	3	of	of	IN
cord-018764-02l423mk	16	4	ensuing	ensue	VBG
cord-018764-02l423mk	16	5	energy	energy	NN
cord-018764-02l423mk	16	6	depletion	depletion	NN
cord-018764-02l423mk	16	7	(	(	-LRB-
cord-018764-02l423mk	16	8	both	both	DT
cord-018764-02l423mk	16	9	temporal	temporal	JJ
cord-018764-02l423mk	16	10	and	and	CC
cord-018764-02l423mk	16	11	spatial	spatial	JJ
cord-018764-02l423mk	16	12	)	)	-RRB-
cord-018764-02l423mk	16	13	throughout	throughout	IN
cord-018764-02l423mk	16	14	the	the	DT
cord-018764-02l423mk	16	15	cells	cell	NNS
cord-018764-02l423mk	16	16	in	in	IN
cord-018764-02l423mk	16	17	the	the	DT
cord-018764-02l423mk	16	18	body	body	NN
cord-018764-02l423mk	16	19	present	present	JJ
cord-018764-02l423mk	16	20	as	as	IN
cord-018764-02l423mk	16	21	different	different	JJ
cord-018764-02l423mk	16	22	clinical	clinical	JJ
cord-018764-02l423mk	16	23	syndromes	syndrome	NNS
cord-018764-02l423mk	16	24	.	.	.
cord-018764-02l423mk	17	1	This	this	DT
cord-018764-02l423mk	17	2	chapter	chapter	NN
cord-018764-02l423mk	17	3	draws	draw	VBZ
cord-018764-02l423mk	17	4	attention	attention	NN
cord-018764-02l423mk	17	5	to	to	IN
cord-018764-02l423mk	17	6	the	the	DT
cord-018764-02l423mk	17	7	over	over	RB
cord-018764-02l423mk	17	8	-	-	HYPH
cord-018764-02l423mk	17	9	arching	arch	VBG
cord-018764-02l423mk	17	10	position	position	NN
cord-018764-02l423mk	17	11	that	that	IN
cord-018764-02l423mk	17	12	inflammatory	inflammatory	JJ
cord-018764-02l423mk	17	13	cytokines	cytokine	NNS
cord-018764-02l423mk	17	14	are	be	VBP
cord-018764-02l423mk	17	15	beginning	begin	VBG
cord-018764-02l423mk	17	16	to	to	TO
cord-018764-02l423mk	17	17	occupy	occupy	VB
cord-018764-02l423mk	17	18	in	in	IN
cord-018764-02l423mk	17	19	the	the	DT
cord-018764-02l423mk	17	20	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	17	21	of	of	IN
cord-018764-02l423mk	17	22	acute	acute	JJ
cord-018764-02l423mk	17	23	malaria	malaria	NN
cord-018764-02l423mk	17	24	and	and	CC
cord-018764-02l423mk	17	25	other	other	JJ
cord-018764-02l423mk	17	26	acute	acute	JJ
cord-018764-02l423mk	17	27	infections	infection	NNS
cord-018764-02l423mk	17	28	.	.	.
cord-018764-02l423mk	18	1	The	the	DT
cord-018764-02l423mk	18	2	influence	influence	NN
cord-018764-02l423mk	18	3	of	of	IN
cord-018764-02l423mk	18	4	inflammatory	inflammatory	JJ
cord-018764-02l423mk	18	5	cytokines	cytokine	NNS
cord-018764-02l423mk	18	6	on	on	IN
cord-018764-02l423mk	18	7	cellular	cellular	JJ
cord-018764-02l423mk	18	8	function	function	NN
cord-018764-02l423mk	18	9	offers	offer	VBZ
cord-018764-02l423mk	18	10	a	a	DT
cord-018764-02l423mk	18	11	molecular	molecular	JJ
cord-018764-02l423mk	18	12	framework	framework	NN
cord-018764-02l423mk	18	13	to	to	TO
cord-018764-02l423mk	18	14	explain	explain	VB
cord-018764-02l423mk	18	15	the	the	DT
cord-018764-02l423mk	18	16	multiple	multiple	JJ
cord-018764-02l423mk	18	17	clinical	clinical	JJ
cord-018764-02l423mk	18	18	syndromes	syndrome	NNS
cord-018764-02l423mk	18	19	that	that	WDT
cord-018764-02l423mk	18	20	are	be	VBP
cord-018764-02l423mk	18	21	observed	observe	VBN
cord-018764-02l423mk	18	22	during	during	IN
cord-018764-02l423mk	18	23	acute	acute	JJ
cord-018764-02l423mk	18	24	malarial	malarial	JJ
cord-018764-02l423mk	18	25	illness	illness	NN
cord-018764-02l423mk	18	26	,	,	,
cord-018764-02l423mk	18	27	and	and	CC
cord-018764-02l423mk	18	28	provides	provide	VBZ
cord-018764-02l423mk	18	29	a	a	DT
cord-018764-02l423mk	18	30	fresh	fresh	JJ
cord-018764-02l423mk	18	31	avenue	avenue	NN
cord-018764-02l423mk	18	32	of	of	IN
cord-018764-02l423mk	18	33	investigation	investigation	NN
cord-018764-02l423mk	18	34	for	for	IN
cord-018764-02l423mk	18	35	adjunct	adjunct	JJ
cord-018764-02l423mk	18	36	therapies	therapy	NNS
cord-018764-02l423mk	18	37	to	to	TO
cord-018764-02l423mk	18	38	ameliorate	ameliorate	VB
cord-018764-02l423mk	18	39	the	the	DT
cord-018764-02l423mk	18	40	malarial	malarial	JJ
cord-018764-02l423mk	18	41	disease	disease	NN
cord-018764-02l423mk	18	42	process	process	NN
cord-018764-02l423mk	18	43	.	.	.
cord-018764-02l423mk	19	1	Although	although	IN
cord-018764-02l423mk	19	2	many	many	JJ
cord-018764-02l423mk	19	3	species	specie	NNS
cord-018764-02l423mk	19	4	of	of	IN
cord-018764-02l423mk	19	5	malarial	malarial	JJ
cord-018764-02l423mk	19	6	parasite	parasite	NN
cord-018764-02l423mk	19	7	exist	exist	VBP
cord-018764-02l423mk	19	8	,	,	,
cord-018764-02l423mk	19	9	only	only	RB
cord-018764-02l423mk	19	10	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	19	11	falciparum	falciparum	NN
cord-018764-02l423mk	19	12	,	,	,
cord-018764-02l423mk	19	13	vivax	vivax	NN
cord-018764-02l423mk	19	14	,	,	,
cord-018764-02l423mk	19	15	ovale	ovale	NN
cord-018764-02l423mk	19	16	,	,	,
cord-018764-02l423mk	19	17	and	and	CC
cord-018764-02l423mk	19	18	malariae	malariae	NNP
cord-018764-02l423mk	19	19	are	be	VBP
cord-018764-02l423mk	19	20	classically	classically	RB
cord-018764-02l423mk	19	21	associated	associate	VBN
cord-018764-02l423mk	19	22	with	with	IN
cord-018764-02l423mk	19	23	human	human	JJ
cord-018764-02l423mk	19	24	infection	infection	NN
cord-018764-02l423mk	19	25	.	.	.
cord-018764-02l423mk	20	1	The	the	DT
cord-018764-02l423mk	20	2	former	former	JJ
cord-018764-02l423mk	20	3	two	two	CD
cord-018764-02l423mk	20	4	species	specie	NNS
cord-018764-02l423mk	20	5	are	be	VBP
cord-018764-02l423mk	20	6	most	most	RBS
cord-018764-02l423mk	20	7	frequently	frequently	RB
cord-018764-02l423mk	20	8	associated	associate	VBN
cord-018764-02l423mk	20	9	with	with	IN
cord-018764-02l423mk	20	10	malarial	malarial	JJ
cord-018764-02l423mk	20	11	disease	disease	NN
cord-018764-02l423mk	20	12	in	in	IN
cord-018764-02l423mk	20	13	humans	human	NNS
cord-018764-02l423mk	20	14	,	,	,
cord-018764-02l423mk	20	15	with	with	IN
cord-018764-02l423mk	20	16	severe	severe	JJ
cord-018764-02l423mk	20	17	malarial	malarial	JJ
cord-018764-02l423mk	20	18	disease	disease	NN
cord-018764-02l423mk	20	19	almost	almost	RB
cord-018764-02l423mk	20	20	exclusively	exclusively	RB
cord-018764-02l423mk	20	21	associated	associate	VBN
cord-018764-02l423mk	20	22	with	with	IN
cord-018764-02l423mk	20	23	P.	p.	NN
cord-018764-02l423mk	20	24	falciparum	falciparum	NN
cord-018764-02l423mk	20	25	infection	infection	NN
cord-018764-02l423mk	20	26	.	.	.
cord-018764-02l423mk	21	1	Falciparum	falciparum	NN
cord-018764-02l423mk	21	2	malaria	malaria	NN
cord-018764-02l423mk	21	3	is	be	VBZ
cord-018764-02l423mk	21	4	responsible	responsible	JJ
cord-018764-02l423mk	21	5	for	for	IN
cord-018764-02l423mk	21	6	considerable	considerable	JJ
cord-018764-02l423mk	21	7	morbidity	morbidity	NN
cord-018764-02l423mk	21	8	(	(	-LRB-
cord-018764-02l423mk	21	9	300	300	CD
cord-018764-02l423mk	21	10	-	-	SYM
cord-018764-02l423mk	21	11	500	500	CD
cord-018764-02l423mk	21	12	million	million	CD
cord-018764-02l423mk	21	13	annual	annual	JJ
cord-018764-02l423mk	21	14	clinical	clinical	JJ
cord-018764-02l423mk	21	15	cases	case	NNS
cord-018764-02l423mk	21	16	)	)	-RRB-
cord-018764-02l423mk	21	17	and	and	CC
cord-018764-02l423mk	21	18	death	death	NN
cord-018764-02l423mk	21	19	across	across	IN
cord-018764-02l423mk	21	20	the	the	DT
cord-018764-02l423mk	21	21	globe	globe	NN
cord-018764-02l423mk	21	22	,	,	,
cord-018764-02l423mk	21	23	with	with	IN
cord-018764-02l423mk	21	24	a	a	DT
cord-018764-02l423mk	21	25	particular	particular	JJ
cord-018764-02l423mk	21	26	burden	burden	NN
cord-018764-02l423mk	21	27	of	of	IN
cord-018764-02l423mk	21	28	mortality	mortality	NN
cord-018764-02l423mk	21	29	among	among	IN
cord-018764-02l423mk	21	30	children	child	NNS
cord-018764-02l423mk	21	31	in	in	IN
cord-018764-02l423mk	21	32	sub	sub	JJ
cord-018764-02l423mk	21	33	-	-	JJ
cord-018764-02l423mk	21	34	Saharan	saharan	JJ
cord-018764-02l423mk	21	35	Africa	Africa	NNP
cord-018764-02l423mk	21	36	.	.	.
cord-018764-02l423mk	22	1	Infection	infection	NN
cord-018764-02l423mk	22	2	with	with	IN
cord-018764-02l423mk	22	3	P.	p.	NN
cord-018764-02l423mk	22	4	vivax	vivax	NN
cord-018764-02l423mk	22	5	is	be	VBZ
cord-018764-02l423mk	22	6	rarely	rarely	RB
cord-018764-02l423mk	22	7	fatal	fatal	JJ
cord-018764-02l423mk	22	8	,	,	,
cord-018764-02l423mk	22	9	but	but	CC
cord-018764-02l423mk	22	10	is	be	VBZ
cord-018764-02l423mk	22	11	associated	associate	VBN
cord-018764-02l423mk	22	12	with	with	IN
cord-018764-02l423mk	22	13	considerable	considerable	JJ
cord-018764-02l423mk	22	14	morbidity	morbidity	NN
cord-018764-02l423mk	22	15	outside	outside	IN
cord-018764-02l423mk	22	16	the	the	DT
cord-018764-02l423mk	22	17	African	african	JJ
cord-018764-02l423mk	22	18	continent	continent	NN
cord-018764-02l423mk	22	19	.	.	.
cord-018764-02l423mk	23	1	It	-PRON-	PRP
cord-018764-02l423mk	23	2	should	should	MD
cord-018764-02l423mk	23	3	also	also	RB
cord-018764-02l423mk	23	4	be	be	VB
cord-018764-02l423mk	23	5	recalled	recall	VBN
cord-018764-02l423mk	23	6	that	that	IN
cord-018764-02l423mk	23	7	malaria	malaria	NN
cord-018764-02l423mk	23	8	causes	cause	VBZ
cord-018764-02l423mk	23	9	social	social	JJ
cord-018764-02l423mk	23	10	and	and	CC
cord-018764-02l423mk	23	11	economic	economic	JJ
cord-018764-02l423mk	23	12	disruption	disruption	NN
cord-018764-02l423mk	23	13	on	on	IN
cord-018764-02l423mk	23	14	a	a	DT
cord-018764-02l423mk	23	15	uniquely	uniquely	RB
cord-018764-02l423mk	23	16	large	large	JJ
cord-018764-02l423mk	23	17	scale	scale	NN
cord-018764-02l423mk	23	18	[	[	-LRB-
cord-018764-02l423mk	23	19	1	1	CD
cord-018764-02l423mk	23	20	]	]	-RRB-
cord-018764-02l423mk	23	21	.	.	.
cord-018764-02l423mk	24	1	Severe	severe	JJ
cord-018764-02l423mk	24	2	adult	adult	NN
cord-018764-02l423mk	24	3	malaria	malaria	NN
cord-018764-02l423mk	24	4	is	be	VBZ
cord-018764-02l423mk	24	5	a	a	DT
cord-018764-02l423mk	24	6	clinical	clinical	JJ
cord-018764-02l423mk	24	7	syndrome	syndrome	NN
cord-018764-02l423mk	24	8	originally	originally	RB
cord-018764-02l423mk	24	9	classified	classify	VBD
cord-018764-02l423mk	24	10	using	use	VBG
cord-018764-02l423mk	24	11	10	10	CD
cord-018764-02l423mk	24	12	defining	define	VBG
cord-018764-02l423mk	24	13	and	and	CC
cord-018764-02l423mk	24	14	5	5	CD
cord-018764-02l423mk	24	15	supportive	supportive	JJ
cord-018764-02l423mk	24	16	(	(	-LRB-
cord-018764-02l423mk	24	17	often	often	RB
cord-018764-02l423mk	24	18	overlapping	overlap	VBG
cord-018764-02l423mk	24	19	)	)	-RRB-
cord-018764-02l423mk	24	20	clinical	clinical	JJ
cord-018764-02l423mk	24	21	features	feature	NNS
cord-018764-02l423mk	24	22	unified	unify	VBN
cord-018764-02l423mk	24	23	by	by	IN
cord-018764-02l423mk	24	24	the	the	DT
cord-018764-02l423mk	24	25	presence	presence	NN
cord-018764-02l423mk	24	26	of	of	IN
cord-018764-02l423mk	24	27	asexual	asexual	JJ
cord-018764-02l423mk	24	28	malarial	malarial	JJ
cord-018764-02l423mk	24	29	parasites	parasite	NNS
cord-018764-02l423mk	24	30	in	in	IN
cord-018764-02l423mk	24	31	the	the	DT
cord-018764-02l423mk	24	32	peripheral	peripheral	JJ
cord-018764-02l423mk	24	33	blood	blood	NN
cord-018764-02l423mk	24	34	smear	smear	NN
cord-018764-02l423mk	24	35	[	[	-LRB-
cord-018764-02l423mk	24	36	2	2	CD
cord-018764-02l423mk	24	37	]	]	-RRB-
cord-018764-02l423mk	24	38	.	.	.
cord-018764-02l423mk	25	1	Based	base	VBN
cord-018764-02l423mk	25	2	on	on	IN
cord-018764-02l423mk	25	3	observations	observation	NNS
cord-018764-02l423mk	25	4	of	of	IN
cord-018764-02l423mk	25	5	children	child	NNS
cord-018764-02l423mk	25	6	in	in	IN
cord-018764-02l423mk	25	7	coastal	coastal	JJ
cord-018764-02l423mk	25	8	Kenya	Kenya	NNP
cord-018764-02l423mk	25	9	,	,	,
cord-018764-02l423mk	25	10	paediatric	paediatric	JJ
cord-018764-02l423mk	25	11	severe	severe	JJ
cord-018764-02l423mk	25	12	malaria	malaria	NN
cord-018764-02l423mk	25	13	has	have	VBZ
cord-018764-02l423mk	25	14	similarly	similarly	RB
cord-018764-02l423mk	25	15	been	be	VBN
cord-018764-02l423mk	25	16	distilled	distil	VBN
cord-018764-02l423mk	25	17	into	into	IN
cord-018764-02l423mk	25	18	three	three	CD
cord-018764-02l423mk	25	19	main	main	NN
cord-018764-02l423mk	25	20	(	(	-LRB-
cord-018764-02l423mk	25	21	again	again	RB
cord-018764-02l423mk	25	22	often	often	RB
cord-018764-02l423mk	25	23	overlapping	overlap	VBG
cord-018764-02l423mk	25	24	)	)	-RRB-
cord-018764-02l423mk	25	25	clinical	clinical	JJ
cord-018764-02l423mk	25	26	syndromes	syndrome	NNS
cord-018764-02l423mk	25	27	,	,	,
cord-018764-02l423mk	25	28	anaemia	anaemia	NN
cord-018764-02l423mk	25	29	,	,	,
cord-018764-02l423mk	25	30	respiratory	respiratory	JJ
cord-018764-02l423mk	25	31	distress	distress	NN
cord-018764-02l423mk	25	32	(	(	-LRB-
cord-018764-02l423mk	25	33	an	an	DT
cord-018764-02l423mk	25	34	indicator	indicator	NN
cord-018764-02l423mk	25	35	of	of	IN
cord-018764-02l423mk	25	36	an	an	DT
cord-018764-02l423mk	25	37	underlying	underlie	VBG
cord-018764-02l423mk	25	38	metabolic	metabolic	JJ
cord-018764-02l423mk	25	39	acidosis	acidosis	NN
cord-018764-02l423mk	25	40	)	)	-RRB-
cord-018764-02l423mk	25	41	and	and	CC
cord-018764-02l423mk	25	42	impairment	impairment	NN
cord-018764-02l423mk	25	43	of	of	IN
cord-018764-02l423mk	25	44	consciousness	consciousness	NN
cord-018764-02l423mk	25	45	[	[	-LRB-
cord-018764-02l423mk	25	46	3	3	CD
cord-018764-02l423mk	25	47	]	]	-RRB-
cord-018764-02l423mk	25	48	.	.	.
cord-018764-02l423mk	26	1	These	these	DT
cord-018764-02l423mk	26	2	clinical	clinical	JJ
cord-018764-02l423mk	26	3	syndromes	syndrome	NNS
cord-018764-02l423mk	26	4	are	be	VBP
cord-018764-02l423mk	26	5	discussed	discuss	VBN
cord-018764-02l423mk	26	6	below	below	RB
cord-018764-02l423mk	26	7	.	.	.
cord-018764-02l423mk	27	1	In	in	IN
cord-018764-02l423mk	27	2	the	the	DT
cord-018764-02l423mk	27	3	review	review	NN
cord-018764-02l423mk	27	4	mentioned	mention	VBN
cord-018764-02l423mk	27	5	above	above	IN
cord-018764-02l423mk	27	6	[	[	-LRB-
cord-018764-02l423mk	27	7	3	3	CD
cord-018764-02l423mk	27	8	]	]	-RRB-
cord-018764-02l423mk	27	9	,	,	,
cord-018764-02l423mk	27	10	the	the	DT
cord-018764-02l423mk	27	11	authors	author	NNS
cord-018764-02l423mk	27	12	'	'	POS
cord-018764-02l423mk	27	13	judicious	judicious	JJ
cord-018764-02l423mk	27	14	use	use	NN
cord-018764-02l423mk	27	15	of	of	IN
cord-018764-02l423mk	27	16	the	the	DT
cord-018764-02l423mk	27	17	term	term	NN
cord-018764-02l423mk	27	18	impaired	impair	VBN
cord-018764-02l423mk	27	19	consciousness	consciousness	NN
cord-018764-02l423mk	27	20	,	,	,
cord-018764-02l423mk	27	21	rather	rather	RB
cord-018764-02l423mk	27	22	than	than	IN
cord-018764-02l423mk	27	23	cerebral	cerebral	JJ
cord-018764-02l423mk	27	24	malaria	malaria	NN
cord-018764-02l423mk	27	25	(	(	-LRB-
cord-018764-02l423mk	27	26	CM	CM	NNP
cord-018764-02l423mk	27	27	)	)	-RRB-
cord-018764-02l423mk	27	28	,	,	,
cord-018764-02l423mk	27	29	promoted	promote	VBD
cord-018764-02l423mk	27	30	the	the	DT
cord-018764-02l423mk	27	31	useful	useful	JJ
cord-018764-02l423mk	27	32	concept	concept	NN
cord-018764-02l423mk	27	33	that	that	IN
cord-018764-02l423mk	27	34	the	the	DT
cord-018764-02l423mk	27	35	neurological	neurological	JJ
cord-018764-02l423mk	27	36	features	feature	NNS
cord-018764-02l423mk	27	37	(	(	-LRB-
cord-018764-02l423mk	27	38	and	and	CC
cord-018764-02l423mk	27	39	in	in	IN
cord-018764-02l423mk	27	40	-	-	HYPH
cord-018764-02l423mk	27	41	turn	turn	VB
cord-018764-02l423mk	27	42	the	the	DT
cord-018764-02l423mk	27	43	underlying	underlie	VBG
cord-018764-02l423mk	27	44	mechanisms	mechanism	NNS
cord-018764-02l423mk	27	45	)	)	-RRB-
cord-018764-02l423mk	27	46	associated	associate	VBN
cord-018764-02l423mk	27	47	with	with	IN
cord-018764-02l423mk	27	48	severe	severe	JJ
cord-018764-02l423mk	27	49	malaria	malaria	NN
cord-018764-02l423mk	27	50	are	be	VBP
cord-018764-02l423mk	27	51	not	not	RB
cord-018764-02l423mk	27	52	necessarily	necessarily	RB
cord-018764-02l423mk	27	53	unique	unique	JJ
cord-018764-02l423mk	27	54	to	to	IN
cord-018764-02l423mk	27	55	malarial	malarial	JJ
cord-018764-02l423mk	27	56	disease	disease	NN
cord-018764-02l423mk	27	57	.	.	.
cord-018764-02l423mk	28	1	Indeed	indeed	RB
cord-018764-02l423mk	28	2	,	,	,
cord-018764-02l423mk	28	3	over	over	IN
cord-018764-02l423mk	28	4	60	60	CD
cord-018764-02l423mk	28	5	years	year	NNS
cord-018764-02l423mk	28	6	ago	ago	RB
cord-018764-02l423mk	28	7	,	,	,
cord-018764-02l423mk	28	8	it	-PRON-	PRP
cord-018764-02l423mk	28	9	was	be	VBD
cord-018764-02l423mk	28	10	noted	note	VBN
cord-018764-02l423mk	28	11	that	that	IN
cord-018764-02l423mk	28	12	the	the	DT
cord-018764-02l423mk	28	13	clinical	clinical	JJ
cord-018764-02l423mk	28	14	features	feature	NNS
cord-018764-02l423mk	28	15	of	of	IN
cord-018764-02l423mk	28	16	malaria	malaria	NN
cord-018764-02l423mk	28	17	can	can	MD
cord-018764-02l423mk	28	18	resemble	resemble	VB
cord-018764-02l423mk	28	19	those	those	DT
cord-018764-02l423mk	28	20	exhibited	exhibit	VBN
cord-018764-02l423mk	28	21	in	in	IN
cord-018764-02l423mk	28	22	patients	patient	NNS
cord-018764-02l423mk	28	23	with	with	IN
cord-018764-02l423mk	28	24	fulminant	fulminant	JJ
cord-018764-02l423mk	28	25	bacterial	bacterial	JJ
cord-018764-02l423mk	28	26	or	or	CC
cord-018764-02l423mk	28	27	viral	viral	JJ
cord-018764-02l423mk	28	28	infections	infection	NNS
cord-018764-02l423mk	28	29	[	[	-LRB-
cord-018764-02l423mk	28	30	4	4	CD
cord-018764-02l423mk	28	31	]	]	-RRB-
cord-018764-02l423mk	28	32	.	.	.
cord-018764-02l423mk	29	1	Severe	severe	JJ
cord-018764-02l423mk	29	2	malaria	malaria	NN
cord-018764-02l423mk	29	3	has	have	VBZ
cord-018764-02l423mk	29	4	been	be	VBN
cord-018764-02l423mk	29	5	intensively	intensively	RB
cord-018764-02l423mk	29	6	studied	study	VBN
cord-018764-02l423mk	29	7	,	,	,
cord-018764-02l423mk	29	8	and	and	CC
cord-018764-02l423mk	29	9	there	there	EX
cord-018764-02l423mk	29	10	appears	appear	VBZ
cord-018764-02l423mk	29	11	to	to	TO
cord-018764-02l423mk	29	12	be	be	VB
cord-018764-02l423mk	29	13	a	a	DT
cord-018764-02l423mk	29	14	complex	complex	JJ
cord-018764-02l423mk	29	15	interplay	interplay	NN
cord-018764-02l423mk	29	16	between	between	IN
cord-018764-02l423mk	29	17	host	host	NN
cord-018764-02l423mk	29	18	infection	infection	NN
cord-018764-02l423mk	29	19	and	and	CC
cord-018764-02l423mk	29	20	disease	disease	NN
cord-018764-02l423mk	29	21	.	.	.
cord-018764-02l423mk	30	1	This	this	DT
cord-018764-02l423mk	30	2	is	be	VBZ
cord-018764-02l423mk	30	3	highlighted	highlight	VBN
cord-018764-02l423mk	30	4	by	by	IN
cord-018764-02l423mk	30	5	the	the	DT
cord-018764-02l423mk	30	6	different	different	JJ
cord-018764-02l423mk	30	7	clinical	clinical	JJ
cord-018764-02l423mk	30	8	manifestations	manifestation	NNS
cord-018764-02l423mk	30	9	of	of	IN
cord-018764-02l423mk	30	10	severe	severe	JJ
cord-018764-02l423mk	30	11	malaria	malaria	NN
cord-018764-02l423mk	30	12	exhibited	exhibit	VBN
cord-018764-02l423mk	30	13	by	by	IN
cord-018764-02l423mk	30	14	children	child	NNS
cord-018764-02l423mk	30	15	and	and	CC
cord-018764-02l423mk	30	16	adults	adult	NNS
cord-018764-02l423mk	30	17	.	.	.
cord-018764-02l423mk	31	1	These	these	DT
cord-018764-02l423mk	31	2	differences	difference	NNS
cord-018764-02l423mk	31	3	are	be	VBP
cord-018764-02l423mk	31	4	undoubtedly	undoubtedly	RB
cord-018764-02l423mk	31	5	,	,	,
cord-018764-02l423mk	31	6	in	in	IN
cord-018764-02l423mk	31	7	part	part	NN
cord-018764-02l423mk	31	8	,	,	,
cord-018764-02l423mk	31	9	a	a	DT
cord-018764-02l423mk	31	10	function	function	NN
cord-018764-02l423mk	31	11	of	of	IN
cord-018764-02l423mk	31	12	patient	patient	JJ
cord-018764-02l423mk	31	13	age	age	NN
cord-018764-02l423mk	31	14	.	.	.
cord-018764-02l423mk	32	1	However	however	RB
cord-018764-02l423mk	32	2	,	,	,
cord-018764-02l423mk	32	3	age	age	NN
cord-018764-02l423mk	32	4	is	be	VBZ
cord-018764-02l423mk	32	5	just	just	RB
cord-018764-02l423mk	32	6	one	one	CD
cord-018764-02l423mk	32	7	of	of	IN
cord-018764-02l423mk	32	8	a	a	DT
cord-018764-02l423mk	32	9	series	series	NN
cord-018764-02l423mk	32	10	of	of	IN
cord-018764-02l423mk	32	11	interacting	interact	VBG
cord-018764-02l423mk	32	12	factors	factor	NNS
cord-018764-02l423mk	32	13	,	,	,
cord-018764-02l423mk	32	14	e.g.	e.g.	DT
cord-018764-02l423mk	32	15	geographical	geographical	JJ
cord-018764-02l423mk	32	16	region	region	NN
cord-018764-02l423mk	32	17	,	,	,
cord-018764-02l423mk	32	18	level	level	NN
cord-018764-02l423mk	32	19	of	of	IN
cord-018764-02l423mk	32	20	malaria	malaria	NN
cord-018764-02l423mk	32	21	transmission	transmission	NN
cord-018764-02l423mk	32	22	,	,	,
cord-018764-02l423mk	32	23	degree	degree	NN
cord-018764-02l423mk	32	24	of	of	IN
cord-018764-02l423mk	32	25	previous	previous	JJ
cord-018764-02l423mk	32	26	malaria	malaria	NN
cord-018764-02l423mk	32	27	exposure	exposure	NN
cord-018764-02l423mk	32	28	,	,	,
cord-018764-02l423mk	32	29	length	length	NN
cord-018764-02l423mk	32	30	of	of	IN
cord-018764-02l423mk	32	31	illness	illness	NN
cord-018764-02l423mk	32	32	prior	prior	RB
cord-018764-02l423mk	32	33	to	to	IN
cord-018764-02l423mk	32	34	treatment	treatment	NN
cord-018764-02l423mk	32	35	and	and	CC
cord-018764-02l423mk	32	36	host	host	NN
cord-018764-02l423mk	32	37	immunity	immunity	NN
cord-018764-02l423mk	32	38	that	that	WDT
cord-018764-02l423mk	32	39	may	may	MD
cord-018764-02l423mk	32	40	influence	influence	VB
cord-018764-02l423mk	32	41	the	the	DT
cord-018764-02l423mk	32	42	clinical	clinical	JJ
cord-018764-02l423mk	32	43	presentation	presentation	NN
cord-018764-02l423mk	32	44	of	of	IN
cord-018764-02l423mk	32	45	severe	severe	JJ
cord-018764-02l423mk	32	46	malaria	malaria	NN
cord-018764-02l423mk	32	47	.	.	.
cord-018764-02l423mk	33	1	This	this	DT
cord-018764-02l423mk	33	2	variation	variation	NN
cord-018764-02l423mk	33	3	in	in	IN
cord-018764-02l423mk	33	4	clinical	clinical	JJ
cord-018764-02l423mk	33	5	presentation	presentation	NN
cord-018764-02l423mk	33	6	has	have	VBZ
cord-018764-02l423mk	33	7	been	be	VBN
cord-018764-02l423mk	33	8	mirrored	mirror	VBN
cord-018764-02l423mk	33	9	by	by	IN
cord-018764-02l423mk	33	10	a	a	DT
cord-018764-02l423mk	33	11	similar	similar	JJ
cord-018764-02l423mk	33	12	multitude	multitude	NN
cord-018764-02l423mk	33	13	of	of	IN
cord-018764-02l423mk	33	14	proposals	proposal	NNS
cord-018764-02l423mk	33	15	regarding	regard	VBG
cord-018764-02l423mk	33	16	the	the	DT
cord-018764-02l423mk	33	17	functional	functional	JJ
cord-018764-02l423mk	33	18	mechanisms	mechanism	NNS
cord-018764-02l423mk	33	19	underlying	underlie	VBG
cord-018764-02l423mk	33	20	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	33	21	of	of	IN
cord-018764-02l423mk	33	22	severe	severe	JJ
cord-018764-02l423mk	33	23	malaria	malaria	NN
cord-018764-02l423mk	33	24	.	.	.
cord-018764-02l423mk	34	1	One	one	CD
cord-018764-02l423mk	34	2	concept	concept	NN
cord-018764-02l423mk	34	3	of	of	IN
cord-018764-02l423mk	34	4	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	34	5	consistently	consistently	RB
cord-018764-02l423mk	34	6	articulated	articulate	VBN
cord-018764-02l423mk	34	7	has	have	VBZ
cord-018764-02l423mk	34	8	been	be	VBN
cord-018764-02l423mk	34	9	the	the	DT
cord-018764-02l423mk	34	10	'	'	``
cord-018764-02l423mk	34	11	mechanical	mechanical	JJ
cord-018764-02l423mk	34	12	theory	theory	NN
cord-018764-02l423mk	34	13	'	'	''
cord-018764-02l423mk	34	14	.	.	.
cord-018764-02l423mk	35	1	Historically	historically	RB
cord-018764-02l423mk	35	2	,	,	,
cord-018764-02l423mk	35	3	this	this	DT
cord-018764-02l423mk	35	4	theory	theory	NN
cord-018764-02l423mk	35	5	was	be	VBD
cord-018764-02l423mk	35	6	developed	develop	VBN
cord-018764-02l423mk	35	7	from	from	IN
cord-018764-02l423mk	35	8	two	two	CD
cord-018764-02l423mk	35	9	fundamental	fundamental	JJ
cord-018764-02l423mk	35	10	differences	difference	NNS
cord-018764-02l423mk	35	11	between	between	IN
cord-018764-02l423mk	35	12	P.	P.	NNP
cord-018764-02l423mk	35	13	falciparum	falciparum	NN
cord-018764-02l423mk	35	14	and	and	CC
cord-018764-02l423mk	35	15	P.	p.	NN
cord-018764-02l423mk	35	16	vivax	vivax	JJ
cord-018764-02l423mk	35	17	infection	infection	NN
cord-018764-02l423mk	35	18	.	.	.
cord-018764-02l423mk	36	1	Firstly	firstly	RB
cord-018764-02l423mk	36	2	,	,	,
cord-018764-02l423mk	36	3	erythrocytes	erythrocyte	VBZ
cord-018764-02l423mk	36	4	parasitised	parasitise	VBN
cord-018764-02l423mk	36	5	with	with	IN
cord-018764-02l423mk	36	6	P.	P.	NNP
cord-018764-02l423mk	36	7	vivax	vivax	NN
cord-018764-02l423mk	36	8	do	do	VBP
cord-018764-02l423mk	36	9	not	not	RB
cord-018764-02l423mk	36	10	sequester	sequester	VB
cord-018764-02l423mk	36	11	.	.	.
cord-018764-02l423mk	37	1	Secondly	secondly	RB
cord-018764-02l423mk	37	2	,	,	,
cord-018764-02l423mk	37	3	death	death	NN
cord-018764-02l423mk	37	4	following	follow	VBG
cord-018764-02l423mk	37	5	P.	p.	NN
cord-018764-02l423mk	37	6	vivax	vivax	JJ
cord-018764-02l423mk	37	7	infection	infection	NN
cord-018764-02l423mk	37	8	is	be	VBZ
cord-018764-02l423mk	37	9	rare	rare	JJ
cord-018764-02l423mk	37	10	.	.	.
cord-018764-02l423mk	38	1	Consequently	consequently	RB
cord-018764-02l423mk	38	2	,	,	,
cord-018764-02l423mk	38	3	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	38	4	is	be	VBZ
cord-018764-02l423mk	38	5	believed	believe	VBN
cord-018764-02l423mk	38	6	to	to	TO
cord-018764-02l423mk	38	7	be	be	VB
cord-018764-02l423mk	38	8	due	due	JJ
cord-018764-02l423mk	38	9	to	to	IN
cord-018764-02l423mk	38	10	obstruction	obstruction	NN
cord-018764-02l423mk	38	11	of	of	IN
cord-018764-02l423mk	38	12	micro	micro	JJ
cord-018764-02l423mk	38	13	-	-	JJ
cord-018764-02l423mk	38	14	vascular	vascular	JJ
cord-018764-02l423mk	38	15	flow	flow	NN
cord-018764-02l423mk	38	16	by	by	IN
cord-018764-02l423mk	38	17	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	38	18	containing	contain	VBG
cord-018764-02l423mk	38	19	mature	mature	JJ
cord-018764-02l423mk	38	20	-	-	HYPH
cord-018764-02l423mk	38	21	stage	stage	NN
cord-018764-02l423mk	38	22	falciparum	falciparum	NN
cord-018764-02l423mk	38	23	parasites	parasite	NNS
cord-018764-02l423mk	38	24	adhering	adhere	VBG
cord-018764-02l423mk	38	25	to	to	IN
cord-018764-02l423mk	38	26	the	the	DT
cord-018764-02l423mk	38	27	endothelium	endothelium	NN
cord-018764-02l423mk	38	28	(	(	-LRB-
cord-018764-02l423mk	38	29	termed	term	VBN
cord-018764-02l423mk	38	30	sequestration	sequestration	NN
cord-018764-02l423mk	38	31	)	)	-RRB-
cord-018764-02l423mk	38	32	.	.	.
cord-018764-02l423mk	39	1	More	more	RBR
cord-018764-02l423mk	39	2	recently	recently	RB
cord-018764-02l423mk	39	3	the	the	DT
cord-018764-02l423mk	39	4	'	'	``
cord-018764-02l423mk	39	5	cytokine	cytokine	NN
cord-018764-02l423mk	39	6	theory	theory	NN
cord-018764-02l423mk	39	7	of	of	IN
cord-018764-02l423mk	39	8	disease	disease	NN
cord-018764-02l423mk	39	9	'	'	''
cord-018764-02l423mk	39	10	has	have	VBZ
cord-018764-02l423mk	39	11	also	also	RB
cord-018764-02l423mk	39	12	gained	gain	VBN
cord-018764-02l423mk	39	13	credence	credence	NN
cord-018764-02l423mk	39	14	.	.	.
cord-018764-02l423mk	40	1	This	this	DT
cord-018764-02l423mk	40	2	theory	theory	NN
cord-018764-02l423mk	40	3	can	can	MD
cord-018764-02l423mk	40	4	be	be	VB
cord-018764-02l423mk	40	5	applied	apply	VBN
cord-018764-02l423mk	40	6	to	to	IN
cord-018764-02l423mk	40	7	disease	disease	NN
cord-018764-02l423mk	40	8	following	follow	VBG
cord-018764-02l423mk	40	9	both	both	CC
cord-018764-02l423mk	40	10	falciparum	falciparum	NNS
cord-018764-02l423mk	40	11	and	and	CC
cord-018764-02l423mk	40	12	vivax	vivax	JJ
cord-018764-02l423mk	40	13	infection	infection	NN
cord-018764-02l423mk	40	14	.	.	.
cord-018764-02l423mk	41	1	The	the	DT
cord-018764-02l423mk	41	2	lower	low	JJR
cord-018764-02l423mk	41	3	mortality	mortality	NN
cord-018764-02l423mk	41	4	associated	associate	VBN
cord-018764-02l423mk	41	5	with	with	IN
cord-018764-02l423mk	41	6	P.	P.	NNP
cord-018764-02l423mk	41	7	vivax	vivax	NN
cord-018764-02l423mk	41	8	being	being	NN
cord-018764-02l423mk	41	9	explained	explain	VBN
cord-018764-02l423mk	41	10	by	by	IN
cord-018764-02l423mk	41	11	a	a	DT
cord-018764-02l423mk	41	12	relatively	relatively	RB
cord-018764-02l423mk	41	13	milder	mild	JJR
cord-018764-02l423mk	41	14	degree	degree	NN
cord-018764-02l423mk	41	15	of	of	IN
cord-018764-02l423mk	41	16	pro	pro	JJ
cord-018764-02l423mk	41	17	-	-	JJ
cord-018764-02l423mk	41	18	inflammatory	inflammatory	JJ
cord-018764-02l423mk	41	19	imbalance	imbalance	NN
cord-018764-02l423mk	41	20	during	during	IN
cord-018764-02l423mk	41	21	the	the	DT
cord-018764-02l423mk	41	22	host	host	NN
cord-018764-02l423mk	41	23	's	's	POS
cord-018764-02l423mk	41	24	response	response	NN
cord-018764-02l423mk	41	25	to	to	IN
cord-018764-02l423mk	41	26	P.	p.	NN
cord-018764-02l423mk	41	27	vivax	vivax	JJ
cord-018764-02l423mk	41	28	infection	infection	NN
cord-018764-02l423mk	41	29	.	.	.
cord-018764-02l423mk	42	1	The	the	DT
cord-018764-02l423mk	42	2	main	main	JJ
cord-018764-02l423mk	42	3	theme	theme	NN
cord-018764-02l423mk	42	4	of	of	IN
cord-018764-02l423mk	42	5	this	this	DT
cord-018764-02l423mk	42	6	chapter	chapter	NN
cord-018764-02l423mk	42	7	is	be	VBZ
cord-018764-02l423mk	42	8	to	to	TO
cord-018764-02l423mk	42	9	examine	examine	VB
cord-018764-02l423mk	42	10	the	the	DT
cord-018764-02l423mk	42	11	increased	increase	VBN
cord-018764-02l423mk	42	12	understanding	understanding	NN
cord-018764-02l423mk	42	13	of	of	IN
cord-018764-02l423mk	42	14	the	the	DT
cord-018764-02l423mk	42	15	functions	function	NNS
cord-018764-02l423mk	42	16	of	of	IN
cord-018764-02l423mk	42	17	inflammatory	inflammatory	JJ
cord-018764-02l423mk	42	18	cytokines	cytokine	NNS
cord-018764-02l423mk	42	19	gained	gain	VBN
cord-018764-02l423mk	42	20	over	over	IN
cord-018764-02l423mk	42	21	the	the	DT
cord-018764-02l423mk	42	22	past	past	JJ
cord-018764-02l423mk	42	23	15	15	CD
cord-018764-02l423mk	42	24	years	year	NNS
cord-018764-02l423mk	42	25	,	,	,
cord-018764-02l423mk	42	26	and	and	CC
cord-018764-02l423mk	42	27	explore	explore	VB
cord-018764-02l423mk	42	28	how	how	WRB
cord-018764-02l423mk	42	29	these	these	DT
cord-018764-02l423mk	42	30	insights	insight	NNS
cord-018764-02l423mk	42	31	are	be	VBP
cord-018764-02l423mk	42	32	changing	change	VBG
cord-018764-02l423mk	42	33	attitudes	attitude	NNS
cord-018764-02l423mk	42	34	in	in	IN
cord-018764-02l423mk	42	35	malarial	malarial	JJ
cord-018764-02l423mk	42	36	disease	disease	NN
cord-018764-02l423mk	42	37	research	research	NN
cord-018764-02l423mk	42	38	.	.	.
cord-018764-02l423mk	43	1	We	-PRON-	PRP
cord-018764-02l423mk	43	2	also	also	RB
cord-018764-02l423mk	43	3	discuss	discuss	VBP
cord-018764-02l423mk	43	4	how	how	WRB
cord-018764-02l423mk	43	5	two	two	CD
cord-018764-02l423mk	43	6	theories	theory	NNS
cord-018764-02l423mk	43	7	(	(	-LRB-
cord-018764-02l423mk	43	8	mechanical	mechanical	JJ
cord-018764-02l423mk	43	9	and	and	CC
cord-018764-02l423mk	43	10	cytokine	cytokine	NN
cord-018764-02l423mk	43	11	)	)	-RRB-
cord-018764-02l423mk	43	12	can	can	MD
cord-018764-02l423mk	43	13	,	,	,
cord-018764-02l423mk	43	14	as	as	IN
cord-018764-02l423mk	43	15	proposed	propose	VBN
cord-018764-02l423mk	43	16	first	first	RB
cord-018764-02l423mk	43	17	in	in	IN
cord-018764-02l423mk	43	18	a	a	DT
cord-018764-02l423mk	43	19	recognisable	recognisable	JJ
cord-018764-02l423mk	43	20	form	form	NN
cord-018764-02l423mk	43	21	at	at	IN
cord-018764-02l423mk	43	22	least	least	RBS
cord-018764-02l423mk	43	23	65	65	CD
cord-018764-02l423mk	43	24	years	year	NNS
cord-018764-02l423mk	43	25	ago	ago	RB
cord-018764-02l423mk	43	26	[	[	-LRB-
cord-018764-02l423mk	43	27	5	5	CD
cord-018764-02l423mk	43	28	]	]	-RRB-
cord-018764-02l423mk	43	29	,	,	,
cord-018764-02l423mk	43	30	be	be	VB
cord-018764-02l423mk	43	31	complementary	complementary	JJ
cord-018764-02l423mk	43	32	.	.	.
cord-018764-02l423mk	44	1	The	the	DT
cord-018764-02l423mk	44	2	majority	majority	NN
cord-018764-02l423mk	44	3	of	of	IN
cord-018764-02l423mk	44	4	the	the	DT
cord-018764-02l423mk	44	5	clinical	clinical	JJ
cord-018764-02l423mk	44	6	cases	case	NNS
cord-018764-02l423mk	44	7	of	of	IN
cord-018764-02l423mk	44	8	malaria	malaria	NN
cord-018764-02l423mk	44	9	occur	occur	VBP
cord-018764-02l423mk	44	10	in	in	IN
cord-018764-02l423mk	44	11	sub	sub	JJ
cord-018764-02l423mk	44	12	-	-	JJ
cord-018764-02l423mk	44	13	Saharan	saharan	JJ
cord-018764-02l423mk	44	14	Africa	Africa	NNP
cord-018764-02l423mk	44	15	.	.	.
cord-018764-02l423mk	45	1	Nevertheless	nevertheless	RB
cord-018764-02l423mk	45	2	,	,	,
cord-018764-02l423mk	45	3	malaria	malaria	NN
cord-018764-02l423mk	45	4	also	also	RB
cord-018764-02l423mk	45	5	accounts	account	VBZ
cord-018764-02l423mk	45	6	for	for	IN
cord-018764-02l423mk	45	7	considerable	considerable	JJ
cord-018764-02l423mk	45	8	morbidity	morbidity	NN
cord-018764-02l423mk	45	9	and	and	CC
cord-018764-02l423mk	45	10	mortality	mortality	NN
cord-018764-02l423mk	45	11	in	in	IN
cord-018764-02l423mk	45	12	other	other	JJ
cord-018764-02l423mk	45	13	continents	continent	NNS
cord-018764-02l423mk	45	14	particularly	particularly	RB
cord-018764-02l423mk	45	15	South	South	NNP
cord-018764-02l423mk	45	16	East	East	NNP
cord-018764-02l423mk	45	17	Asia	Asia	NNP
cord-018764-02l423mk	45	18	[	[	-LRB-
cord-018764-02l423mk	45	19	6	6	CD
cord-018764-02l423mk	45	20	]	]	-RRB-
cord-018764-02l423mk	45	21	.	.	.
cord-018764-02l423mk	46	1	In	in	IN
cord-018764-02l423mk	46	2	malaria	malaria	NN
cord-018764-02l423mk	46	3	-	-	HYPH
cord-018764-02l423mk	46	4	endemic	endemic	JJ
cord-018764-02l423mk	46	5	regions	region	NNS
cord-018764-02l423mk	46	6	(	(	-LRB-
cord-018764-02l423mk	46	7	e.g.	e.g.	IN
cord-018764-02l423mk	46	8	sub	sub	JJ
cord-018764-02l423mk	46	9	-	-	NNP
cord-018764-02l423mk	46	10	Saharan	Saharan	NNP
cord-018764-02l423mk	46	11	Africa	Africa	NNP
cord-018764-02l423mk	46	12	)	)	-RRB-
cord-018764-02l423mk	46	13	,	,	,
cord-018764-02l423mk	46	14	where	where	WRB
cord-018764-02l423mk	46	15	the	the	DT
cord-018764-02l423mk	46	16	resident	resident	JJ
cord-018764-02l423mk	46	17	population	population	NN
cord-018764-02l423mk	46	18	have	have	VBP
cord-018764-02l423mk	46	19	continuous	continuous	JJ
cord-018764-02l423mk	46	20	exposure	exposure	NN
cord-018764-02l423mk	46	21	to	to	IN
cord-018764-02l423mk	46	22	malarial	malarial	JJ
cord-018764-02l423mk	46	23	parasites	parasite	NNS
cord-018764-02l423mk	46	24	,	,	,
cord-018764-02l423mk	46	25	most	most	JJS
cord-018764-02l423mk	46	26	of	of	IN
cord-018764-02l423mk	46	27	the	the	DT
cord-018764-02l423mk	46	28	severe	severe	JJ
cord-018764-02l423mk	46	29	cases	case	NNS
cord-018764-02l423mk	46	30	are	be	VBP
cord-018764-02l423mk	46	31	seen	see	VBN
cord-018764-02l423mk	46	32	in	in	IN
cord-018764-02l423mk	46	33	children	child	NNS
cord-018764-02l423mk	46	34	[	[	-LRB-
cord-018764-02l423mk	46	35	7	7	CD
cord-018764-02l423mk	46	36	]	]	-RRB-
cord-018764-02l423mk	46	37	.	.	.
cord-018764-02l423mk	47	1	In	in	IN
cord-018764-02l423mk	47	2	hypoendemic	hypoendemic	JJ
cord-018764-02l423mk	47	3	regions	region	NNS
cord-018764-02l423mk	47	4	(	(	-LRB-
cord-018764-02l423mk	47	5	e.g.	e.g.	DT
cord-018764-02l423mk	47	6	South	South	NNP
cord-018764-02l423mk	47	7	East	East	NNP
cord-018764-02l423mk	47	8	Asia	Asia	NNP
cord-018764-02l423mk	47	9	)	)	-RRB-
cord-018764-02l423mk	47	10	,	,	,
cord-018764-02l423mk	47	11	where	where	WRB
cord-018764-02l423mk	47	12	parasite	parasite	NN
cord-018764-02l423mk	47	13	exposure	exposure	NN
cord-018764-02l423mk	47	14	is	be	VBZ
cord-018764-02l423mk	47	15	more	more	RBR
cord-018764-02l423mk	47	16	intermittent	intermittent	JJ
cord-018764-02l423mk	47	17	,	,	,
cord-018764-02l423mk	47	18	cases	case	NNS
cord-018764-02l423mk	47	19	of	of	IN
cord-018764-02l423mk	47	20	severe	severe	JJ
cord-018764-02l423mk	47	21	malaria	malaria	NN
cord-018764-02l423mk	47	22	are	be	VBP
cord-018764-02l423mk	47	23	also	also	RB
cord-018764-02l423mk	47	24	common	common	JJ
cord-018764-02l423mk	47	25	in	in	IN
cord-018764-02l423mk	47	26	adults	adult	NNS
cord-018764-02l423mk	47	27	(	(	-LRB-
cord-018764-02l423mk	47	28	Tab	Tab	NNP
cord-018764-02l423mk	47	29	.	.	.
cord-018764-02l423mk	47	30	1	1	CD
cord-018764-02l423mk	47	31	)	)	-RRB-
cord-018764-02l423mk	47	32	.	.	.
cord-018764-02l423mk	48	1	Clinical	clinical	JJ
cord-018764-02l423mk	48	2	features	feature	NNS
cord-018764-02l423mk	48	3	associated	associate	VBN
cord-018764-02l423mk	48	4	with	with	IN
cord-018764-02l423mk	48	5	malaria	malaria	NN
cord-018764-02l423mk	48	6	mortality	mortality	NN
cord-018764-02l423mk	48	7	vary	vary	VBP
cord-018764-02l423mk	48	8	between	between	IN
cord-018764-02l423mk	48	9	children	child	NNS
cord-018764-02l423mk	48	10	and	and	CC
cord-018764-02l423mk	48	11	adults	adult	NNS
cord-018764-02l423mk	48	12	,	,	,
cord-018764-02l423mk	48	13	but	but	CC
cord-018764-02l423mk	48	14	acidosis	acidosis	NN
cord-018764-02l423mk	48	15	and	and	CC
cord-018764-02l423mk	48	16	coma	coma	NN
cord-018764-02l423mk	48	17	are	be	VBP
cord-018764-02l423mk	48	18	associated	associate	VBN
cord-018764-02l423mk	48	19	with	with	IN
cord-018764-02l423mk	48	20	malarial	malarial	JJ
cord-018764-02l423mk	48	21	mortality	mortality	NN
cord-018764-02l423mk	48	22	in	in	IN
cord-018764-02l423mk	48	23	both	both	DT
cord-018764-02l423mk	48	24	populations	population	NNS
cord-018764-02l423mk	48	25	[	[	-LRB-
cord-018764-02l423mk	48	26	7	7	CD
cord-018764-02l423mk	48	27	,	,	,
cord-018764-02l423mk	48	28	8	8	CD
cord-018764-02l423mk	48	29	]	]	-RRB-
cord-018764-02l423mk	48	30	.	.	.
cord-018764-02l423mk	49	1	Acute	acute	JJ
cord-018764-02l423mk	49	2	renal	renal	JJ
cord-018764-02l423mk	49	3	failure	failure	NN
cord-018764-02l423mk	49	4	(	(	-LRB-
cord-018764-02l423mk	49	5	ARF	ARF	NNP
cord-018764-02l423mk	49	6	)	)	-RRB-
cord-018764-02l423mk	49	7	and	and	CC
cord-018764-02l423mk	49	8	pulmonary	pulmonary	JJ
cord-018764-02l423mk	49	9	oedema	oedema	NN
cord-018764-02l423mk	49	10	,	,	,
cord-018764-02l423mk	49	11	a	a	DT
cord-018764-02l423mk	49	12	marker	marker	NN
cord-018764-02l423mk	49	13	for	for	IN
cord-018764-02l423mk	49	14	adult	adult	JJ
cord-018764-02l423mk	49	15	respiratory	respiratory	JJ
cord-018764-02l423mk	49	16	distress	distress	NN
cord-018764-02l423mk	49	17	syndrome	syndrome	NN
cord-018764-02l423mk	49	18	(	(	-LRB-
cord-018764-02l423mk	49	19	ARDS	ARDS	NNP
cord-018764-02l423mk	49	20	)	)	-RRB-
cord-018764-02l423mk	49	21	,	,	,
cord-018764-02l423mk	49	22	are	be	VBP
cord-018764-02l423mk	49	23	almost	almost	RB
cord-018764-02l423mk	49	24	exclusively	exclusively	RB
cord-018764-02l423mk	49	25	reported	report	VBN
cord-018764-02l423mk	49	26	among	among	IN
cord-018764-02l423mk	49	27	adults	adult	NNS
cord-018764-02l423mk	49	28	[	[	-LRB-
cord-018764-02l423mk	49	29	9	9	CD
cord-018764-02l423mk	49	30	,	,	,
cord-018764-02l423mk	49	31	10	10	CD
cord-018764-02l423mk	49	32	]	]	-RRB-
cord-018764-02l423mk	49	33	,	,	,
cord-018764-02l423mk	49	34	whereas	whereas	IN
cord-018764-02l423mk	49	35	mortality	mortality	NN
cord-018764-02l423mk	49	36	associated	associate	VBN
cord-018764-02l423mk	49	37	with	with	IN
cord-018764-02l423mk	49	38	hypoglycaemia	hypoglycaemia	NN
cord-018764-02l423mk	49	39	is	be	VBZ
cord-018764-02l423mk	49	40	frequently	frequently	RB
cord-018764-02l423mk	49	41	reported	report	VBN
cord-018764-02l423mk	49	42	among	among	IN
cord-018764-02l423mk	49	43	children	child	NNS
cord-018764-02l423mk	49	44	[	[	-LRB-
cord-018764-02l423mk	49	45	11	11	CD
cord-018764-02l423mk	49	46	]	]	-RRB-
cord-018764-02l423mk	49	47	.	.	.
cord-018764-02l423mk	50	1	Why	why	WRB
cord-018764-02l423mk	50	2	malarial	malarial	JJ
cord-018764-02l423mk	50	3	disease	disease	NN
cord-018764-02l423mk	50	4	displays	display	NNS
cord-018764-02l423mk	50	5	such	such	JJ
cord-018764-02l423mk	50	6	age	age	NN
cord-018764-02l423mk	50	7	-	-	HYPH
cord-018764-02l423mk	50	8	related	relate	VBN
cord-018764-02l423mk	50	9	differences	difference	NNS
cord-018764-02l423mk	50	10	in	in	IN
cord-018764-02l423mk	50	11	pathophysiology	pathophysiology	NN
cord-018764-02l423mk	50	12	is	be	VBZ
cord-018764-02l423mk	50	13	unclear	unclear	JJ
cord-018764-02l423mk	50	14	.	.	.
cord-018764-02l423mk	51	1	However	however	RB
cord-018764-02l423mk	51	2	,	,	,
cord-018764-02l423mk	51	3	these	these	DT
cord-018764-02l423mk	51	4	differences	difference	NNS
cord-018764-02l423mk	51	5	are	be	VBP
cord-018764-02l423mk	51	6	not	not	RB
cord-018764-02l423mk	51	7	exclusive	exclusive	JJ
cord-018764-02l423mk	51	8	to	to	IN
cord-018764-02l423mk	51	9	malaria	malaria	NN
cord-018764-02l423mk	51	10	.	.	.
cord-018764-02l423mk	52	1	ARDS	ARDS	NNP
cord-018764-02l423mk	52	2	,	,	,
cord-018764-02l423mk	52	3	which	which	WDT
cord-018764-02l423mk	52	4	is	be	VBZ
cord-018764-02l423mk	52	5	more	more	RBR
cord-018764-02l423mk	52	6	frequently	frequently	RB
cord-018764-02l423mk	52	7	observed	observe	VBN
cord-018764-02l423mk	52	8	as	as	IN
cord-018764-02l423mk	52	9	a	a	DT
cord-018764-02l423mk	52	10	complication	complication	NN
cord-018764-02l423mk	52	11	of	of	IN
cord-018764-02l423mk	52	12	trauma	trauma	NN
cord-018764-02l423mk	52	13	in	in	IN
cord-018764-02l423mk	52	14	adults	adult	NNS
cord-018764-02l423mk	52	15	compared	compare	VBN
cord-018764-02l423mk	52	16	with	with	IN
cord-018764-02l423mk	52	17	children	child	NNS
cord-018764-02l423mk	52	18	[	[	-LRB-
cord-018764-02l423mk	52	19	12	12	CD
cord-018764-02l423mk	52	20	]	]	-RRB-
cord-018764-02l423mk	52	21	,	,	,
cord-018764-02l423mk	52	22	is	be	VBZ
cord-018764-02l423mk	52	23	believed	believe	VBN
cord-018764-02l423mk	52	24	to	to	TO
cord-018764-02l423mk	52	25	reflect	reflect	VB
cord-018764-02l423mk	52	26	an	an	DT
cord-018764-02l423mk	52	27	exaggerated	exaggerated	JJ
cord-018764-02l423mk	52	28	pro	pro	JJ
cord-018764-02l423mk	52	29	-	-	JJ
cord-018764-02l423mk	52	30	inflammatory	inflammatory	JJ
cord-018764-02l423mk	52	31	response	response	NN
cord-018764-02l423mk	52	32	within	within	IN
cord-018764-02l423mk	52	33	the	the	DT
cord-018764-02l423mk	52	34	lung	lung	NN
cord-018764-02l423mk	52	35	[	[	-LRB-
cord-018764-02l423mk	52	36	9	9	CD
cord-018764-02l423mk	52	37	]	]	-RRB-
cord-018764-02l423mk	52	38	.	.	.
cord-018764-02l423mk	53	1	A	a	DT
cord-018764-02l423mk	53	2	possible	possible	JJ
cord-018764-02l423mk	53	3	lead	lead	NN
cord-018764-02l423mk	53	4	for	for	IN
cord-018764-02l423mk	53	5	future	future	JJ
cord-018764-02l423mk	53	6	studies	study	NNS
cord-018764-02l423mk	53	7	on	on	IN
cord-018764-02l423mk	53	8	these	these	DT
cord-018764-02l423mk	53	9	age	age	NN
cord-018764-02l423mk	53	10	-	-	HYPH
cord-018764-02l423mk	53	11	related	relate	VBN
cord-018764-02l423mk	53	12	differences	difference	NNS
cord-018764-02l423mk	53	13	in	in	IN
cord-018764-02l423mk	53	14	malaria	malaria	NN
cord-018764-02l423mk	53	15	is	be	VBZ
cord-018764-02l423mk	53	16	suggested	suggest	VBN
cord-018764-02l423mk	53	17	by	by	IN
cord-018764-02l423mk	53	18	a	a	DT
cord-018764-02l423mk	53	19	report	report	NN
cord-018764-02l423mk	53	20	of	of	IN
cord-018764-02l423mk	53	21	peritoneal	peritoneal	JJ
cord-018764-02l423mk	53	22	macrophages	macrophage	NNS
cord-018764-02l423mk	53	23	collected	collect	VBN
cord-018764-02l423mk	53	24	from	from	IN
cord-018764-02l423mk	53	25	healthy	healthy	JJ
cord-018764-02l423mk	53	26	adults	adult	NNS
cord-018764-02l423mk	53	27	producing	produce	VBG
cord-018764-02l423mk	53	28	much	much	RB
cord-018764-02l423mk	53	29	less	less	JJR
cord-018764-02l423mk	53	30	interleukin	interleukin	NN
cord-018764-02l423mk	53	31	(	(	-LRB-
cord-018764-02l423mk	54	1	IL)-10	IL)-10	NNP
cord-018764-02l423mk	54	2	(	(	-LRB-
cord-018764-02l423mk	54	3	an	an	DT
cord-018764-02l423mk	54	4	anti	anti	JJ
cord-018764-02l423mk	54	5	-	-	JJ
cord-018764-02l423mk	54	6	inflammatory	inflammatory	JJ
cord-018764-02l423mk	54	7	cytokine	cytokine	NN
cord-018764-02l423mk	54	8	)	)	-RRB-
cord-018764-02l423mk	54	9	,	,	,
cord-018764-02l423mk	54	10	but	but	CC
cord-018764-02l423mk	54	11	the	the	DT
cord-018764-02l423mk	54	12	same	same	JJ
cord-018764-02l423mk	54	13	levels	level	NNS
cord-018764-02l423mk	54	14	of	of	IN
cord-018764-02l423mk	54	15	pro	pro	JJ
cord-018764-02l423mk	54	16	-	-	JJ
cord-018764-02l423mk	54	17	inflammatory	inflammatory	JJ
cord-018764-02l423mk	54	18	cytokine	cytokine	NN
cord-018764-02l423mk	54	19	,	,	,
cord-018764-02l423mk	54	20	than	than	IN
cord-018764-02l423mk	54	21	those	those	DT
cord-018764-02l423mk	54	22	from	from	IN
cord-018764-02l423mk	54	23	healthy	healthy	JJ
cord-018764-02l423mk	54	24	children	child	NNS
cord-018764-02l423mk	54	25	,	,	,
cord-018764-02l423mk	54	26	giving	give	VBG
cord-018764-02l423mk	54	27	adults	adult	NNS
cord-018764-02l423mk	54	28	a	a	DT
cord-018764-02l423mk	54	29	much	much	RB
cord-018764-02l423mk	54	30	higher	high	JJR
cord-018764-02l423mk	54	31	pro	pro	JJ
cord-018764-02l423mk	54	32	-	-	JJ
cord-018764-02l423mk	54	33	inflammatory	inflammatory	JJ
cord-018764-02l423mk	54	34	status	status	NN
cord-018764-02l423mk	54	35	[	[	-LRB-
cord-018764-02l423mk	54	36	13	13	CD
cord-018764-02l423mk	54	37	,	,	,
cord-018764-02l423mk	54	38	14	14	CD
cord-018764-02l423mk	54	39	]	]	-RRB-
cord-018764-02l423mk	54	40	.	.	.
cord-018764-02l423mk	55	1	The	the	DT
cord-018764-02l423mk	55	2	mechanism	mechanism	NN
cord-018764-02l423mk	55	3	of	of	IN
cord-018764-02l423mk	55	4	malarial	malarial	JJ
cord-018764-02l423mk	55	5	ARF	arf	NN
cord-018764-02l423mk	55	6	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	55	7	is	be	VBZ
cord-018764-02l423mk	55	8	postulated	postulate	VBN
cord-018764-02l423mk	55	9	to	to	TO
cord-018764-02l423mk	55	10	be	be	VB
cord-018764-02l423mk	55	11	multifactorial	multifactorial	JJ
cord-018764-02l423mk	55	12	,	,	,
cord-018764-02l423mk	55	13	involving	involve	VBG
cord-018764-02l423mk	55	14	mechanical	mechanical	JJ
cord-018764-02l423mk	55	15	,	,	,
cord-018764-02l423mk	55	16	haemodynamic	haemodynamic	JJ
cord-018764-02l423mk	55	17	,	,	,
cord-018764-02l423mk	55	18	and	and	CC
cord-018764-02l423mk	55	19	immunological	immunological	JJ
cord-018764-02l423mk	55	20	factors	factor	NNS
cord-018764-02l423mk	55	21	[	[	-LRB-
cord-018764-02l423mk	55	22	15	15	CD
cord-018764-02l423mk	55	23	]	]	-RRB-
cord-018764-02l423mk	55	24	.	.	.
cord-018764-02l423mk	56	1	The	the	DT
cord-018764-02l423mk	56	2	observation	observation	NN
cord-018764-02l423mk	56	3	that	that	WDT
cord-018764-02l423mk	56	4	ARF	ARF	NNP
cord-018764-02l423mk	56	5	is	be	VBZ
cord-018764-02l423mk	56	6	more	more	RBR
cord-018764-02l423mk	56	7	frequently	frequently	RB
cord-018764-02l423mk	56	8	observed	observe	VBN
cord-018764-02l423mk	56	9	as	as	IN
cord-018764-02l423mk	56	10	a	a	DT
cord-018764-02l423mk	56	11	complication	complication	NN
cord-018764-02l423mk	56	12	of	of	IN
cord-018764-02l423mk	56	13	trauma	trauma	NN
cord-018764-02l423mk	56	14	in	in	IN
cord-018764-02l423mk	56	15	adults	adult	NNS
cord-018764-02l423mk	56	16	than	than	IN
cord-018764-02l423mk	56	17	children	child	NNS
cord-018764-02l423mk	56	18	[	[	-LRB-
cord-018764-02l423mk	56	19	12	12	CD
cord-018764-02l423mk	56	20	]	]	-RRB-
cord-018764-02l423mk	56	21	suggests	suggest	VBZ
cord-018764-02l423mk	56	22	that	that	IN
cord-018764-02l423mk	56	23	age	age	NN
cord-018764-02l423mk	56	24	-	-	HYPH
cord-018764-02l423mk	56	25	related	relate	VBN
cord-018764-02l423mk	56	26	variations	variation	NNS
cord-018764-02l423mk	56	27	in	in	IN
cord-018764-02l423mk	56	28	cytokine	cytokine	NN
cord-018764-02l423mk	56	29	response	response	NN
cord-018764-02l423mk	56	30	may	may	MD
cord-018764-02l423mk	56	31	again	again	RB
cord-018764-02l423mk	56	32	influence	influence	VB
cord-018764-02l423mk	56	33	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	56	34	.	.	.
cord-018764-02l423mk	57	1	Hypoglycaemia	Hypoglycaemia	NNP
cord-018764-02l423mk	57	2	is	be	VBZ
cord-018764-02l423mk	57	3	regarded	regard	VBN
cord-018764-02l423mk	57	4	as	as	IN
cord-018764-02l423mk	57	5	a	a	DT
cord-018764-02l423mk	57	6	more	more	RBR
cord-018764-02l423mk	57	7	frequent	frequent	JJ
cord-018764-02l423mk	57	8	complication	complication	NN
cord-018764-02l423mk	57	9	of	of	IN
cord-018764-02l423mk	57	10	sepsis	sepsis	NN
cord-018764-02l423mk	57	11	in	in	IN
cord-018764-02l423mk	57	12	paediatric	paediatric	JJ
cord-018764-02l423mk	57	13	populations	population	NNS
cord-018764-02l423mk	57	14	compared	compare	VBN
cord-018764-02l423mk	57	15	with	with	IN
cord-018764-02l423mk	57	16	adults	adult	NNS
cord-018764-02l423mk	57	17	[	[	-LRB-
cord-018764-02l423mk	57	18	16	16	CD
cord-018764-02l423mk	57	19	]	]	-RRB-
cord-018764-02l423mk	57	20	.	.	.
cord-018764-02l423mk	58	1	Hypoglycaemia	Hypoglycaemia	NNP
cord-018764-02l423mk	58	2	in	in	IN
cord-018764-02l423mk	58	3	children	child	NNS
cord-018764-02l423mk	58	4	may	may	MD
cord-018764-02l423mk	58	5	,	,	,
cord-018764-02l423mk	58	6	in	in	IN
cord-018764-02l423mk	58	7	part	part	NN
cord-018764-02l423mk	58	8	,	,	,
cord-018764-02l423mk	58	9	be	be	VB
cord-018764-02l423mk	58	10	associated	associate	VBN
cord-018764-02l423mk	58	11	with	with	IN
cord-018764-02l423mk	58	12	a	a	DT
cord-018764-02l423mk	58	13	higher	high	JJR
cord-018764-02l423mk	58	14	basal	basal	NN
cord-018764-02l423mk	58	15	metabolic	metabolic	JJ
cord-018764-02l423mk	58	16	rate	rate	NN
cord-018764-02l423mk	58	17	,	,	,
cord-018764-02l423mk	58	18	and	and	CC
cord-018764-02l423mk	58	19	lower	lower	RBR
cord-018764-02l423mk	58	20	glycolytic	glycolytic	JJ
cord-018764-02l423mk	58	21	[	[	-LRB-
cord-018764-02l423mk	58	22	17	17	CD
cord-018764-02l423mk	58	23	]	]	-RRB-
cord-018764-02l423mk	58	24	and	and	CC
cord-018764-02l423mk	58	25	gluconeogenic	gluconeogenic	JJ
cord-018764-02l423mk	58	26	substrate	substrate	NN
cord-018764-02l423mk	58	27	reserves	reserve	NNS
cord-018764-02l423mk	58	28	compared	compare	VBN
cord-018764-02l423mk	58	29	to	to	IN
cord-018764-02l423mk	58	30	adults	adult	NNS
cord-018764-02l423mk	58	31	[	[	-LRB-
cord-018764-02l423mk	58	32	18	18	CD
cord-018764-02l423mk	58	33	]	]	-RRB-
cord-018764-02l423mk	58	34	.	.	.
cord-018764-02l423mk	59	1	However	however	RB
cord-018764-02l423mk	59	2	,	,	,
cord-018764-02l423mk	59	3	these	these	DT
cord-018764-02l423mk	59	4	substrates	substrate	NNS
cord-018764-02l423mk	59	5	are	be	VBP
cord-018764-02l423mk	59	6	not	not	RB
cord-018764-02l423mk	59	7	always	always	RB
cord-018764-02l423mk	59	8	limiting	limit	VBG
cord-018764-02l423mk	59	9	during	during	IN
cord-018764-02l423mk	59	10	acute	acute	JJ
cord-018764-02l423mk	59	11	paediatric	paediatric	JJ
cord-018764-02l423mk	59	12	malaria	malaria	NN
cord-018764-02l423mk	59	13	,	,	,
cord-018764-02l423mk	59	14	suggesting	suggest	VBG
cord-018764-02l423mk	59	15	functional	functional	JJ
cord-018764-02l423mk	59	16	impairments	impairment	NNS
cord-018764-02l423mk	59	17	of	of	IN
cord-018764-02l423mk	59	18	glucose	glucose	NN
cord-018764-02l423mk	59	19	metabolism	metabolism	NN
cord-018764-02l423mk	59	20	may	may	MD
cord-018764-02l423mk	59	21	also	also	RB
cord-018764-02l423mk	59	22	occur	occur	VB
cord-018764-02l423mk	59	23	[	[	-LRB-
cord-018764-02l423mk	59	24	19	19	CD
cord-018764-02l423mk	59	25	]	]	-RRB-
cord-018764-02l423mk	59	26	.	.	.
cord-018764-02l423mk	60	1	Such	such	JJ
cord-018764-02l423mk	60	2	functional	functional	JJ
cord-018764-02l423mk	60	3	impairments	impairment	NNS
cord-018764-02l423mk	60	4	may	may	MD
cord-018764-02l423mk	60	5	,	,	,
cord-018764-02l423mk	60	6	in	in	IN
cord-018764-02l423mk	60	7	part	part	NN
cord-018764-02l423mk	60	8	,	,	,
cord-018764-02l423mk	60	9	be	be	VB
cord-018764-02l423mk	60	10	influenced	influence	VBN
cord-018764-02l423mk	60	11	by	by	IN
cord-018764-02l423mk	60	12	increases	increase	NNS
cord-018764-02l423mk	60	13	in	in	IN
cord-018764-02l423mk	60	14	inflammatory	inflammatory	JJ
cord-018764-02l423mk	60	15	cytokines	cytokine	NNS
cord-018764-02l423mk	60	16	as	as	IN
cord-018764-02l423mk	60	17	the	the	DT
cord-018764-02l423mk	60	18	infection	infection	NN
cord-018764-02l423mk	60	19	progresses	progress	VBZ
cord-018764-02l423mk	60	20	.	.	.
cord-018764-02l423mk	61	1	Once	once	IN
cord-018764-02l423mk	61	2	the	the	DT
cord-018764-02l423mk	61	3	malarial	malarial	JJ
cord-018764-02l423mk	61	4	parasite	parasite	NN
cord-018764-02l423mk	61	5	was	be	VBD
cord-018764-02l423mk	61	6	identified	identify	VBN
cord-018764-02l423mk	61	7	as	as	IN
cord-018764-02l423mk	61	8	the	the	DT
cord-018764-02l423mk	61	9	cause	cause	NN
cord-018764-02l423mk	61	10	of	of	IN
cord-018764-02l423mk	61	11	disease	disease	NN
cord-018764-02l423mk	61	12	,	,	,
cord-018764-02l423mk	61	13	it	-PRON-	PRP
cord-018764-02l423mk	61	14	quickly	quickly	RB
cord-018764-02l423mk	61	15	became	become	VBD
cord-018764-02l423mk	61	16	apparent	apparent	JJ
cord-018764-02l423mk	61	17	that	that	IN
cord-018764-02l423mk	61	18	illness	illness	NN
cord-018764-02l423mk	61	19	and	and	CC
cord-018764-02l423mk	61	20	death	death	NN
cord-018764-02l423mk	61	21	were	be	VBD
cord-018764-02l423mk	61	22	linked	link	VBN
cord-018764-02l423mk	61	23	with	with	IN
cord-018764-02l423mk	61	24	parasite	parasite	JJ
cord-018764-02l423mk	61	25	invasion	invasion	NN
cord-018764-02l423mk	61	26	into	into	IN
cord-018764-02l423mk	61	27	bloodstream	bloodstream	NN
cord-018764-02l423mk	61	28	and	and	CC
cord-018764-02l423mk	61	29	subsequent	subsequent	JJ
cord-018764-02l423mk	61	30	parasite	parasite	NN
cord-018764-02l423mk	61	31	growth	growth	NN
cord-018764-02l423mk	61	32	within	within	IN
cord-018764-02l423mk	61	33	(	(	-LRB-
cord-018764-02l423mk	61	34	and	and	CC
cord-018764-02l423mk	61	35	release	release	VB
cord-018764-02l423mk	61	36	from	from	IN
cord-018764-02l423mk	61	37	)	)	-RRB-
cord-018764-02l423mk	61	38	the	the	DT
cord-018764-02l423mk	61	39	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	61	40	.	.	.
cord-018764-02l423mk	62	1	By	by	IN
cord-018764-02l423mk	62	2	the	the	DT
cord-018764-02l423mk	62	3	start	start	NN
cord-018764-02l423mk	62	4	of	of	IN
cord-018764-02l423mk	62	5	the	the	DT
cord-018764-02l423mk	62	6	20th	20th	JJ
cord-018764-02l423mk	62	7	century	century	NN
cord-018764-02l423mk	62	8	,	,	,
cord-018764-02l423mk	62	9	two	two	CD
cord-018764-02l423mk	62	10	major	major	JJ
cord-018764-02l423mk	62	11	theories	theory	NNS
cord-018764-02l423mk	62	12	,	,	,
cord-018764-02l423mk	62	13	capillary	capillary	JJ
cord-018764-02l423mk	62	14	blockage	blockage	NN
cord-018764-02l423mk	62	15	and	and	CC
cord-018764-02l423mk	62	16	toxicity	toxicity	NN
cord-018764-02l423mk	62	17	of	of	IN
cord-018764-02l423mk	62	18	the	the	DT
cord-018764-02l423mk	62	19	parasites	parasite	NNS
cord-018764-02l423mk	62	20	themselves	-PRON-	PRP
cord-018764-02l423mk	62	21	,	,	,
cord-018764-02l423mk	62	22	had	have	VBD
cord-018764-02l423mk	62	23	been	be	VBN
cord-018764-02l423mk	62	24	proposed	propose	VBN
cord-018764-02l423mk	62	25	to	to	TO
cord-018764-02l423mk	62	26	explain	explain	VB
cord-018764-02l423mk	62	27	morbidity	morbidity	NN
cord-018764-02l423mk	62	28	and	and	CC
cord-018764-02l423mk	62	29	mortality	mortality	NN
cord-018764-02l423mk	62	30	.	.	.
cord-018764-02l423mk	63	1	Thus	thus	RB
cord-018764-02l423mk	63	2	,	,	,
cord-018764-02l423mk	63	3	the	the	DT
cord-018764-02l423mk	63	4	study	study	NN
cord-018764-02l423mk	63	5	of	of	IN
cord-018764-02l423mk	63	6	malarial	malarial	JJ
cord-018764-02l423mk	63	7	disease	disease	NN
cord-018764-02l423mk	63	8	is	be	VBZ
cord-018764-02l423mk	63	9	not	not	RB
cord-018764-02l423mk	63	10	a	a	DT
cord-018764-02l423mk	63	11	settled	settle	VBN
cord-018764-02l423mk	63	12	story	story	NN
cord-018764-02l423mk	63	13	requiring	require	VBG
cord-018764-02l423mk	63	14	regular	regular	JJ
cord-018764-02l423mk	63	15	updates	update	NNS
cord-018764-02l423mk	63	16	,	,	,
cord-018764-02l423mk	63	17	but	but	CC
cord-018764-02l423mk	63	18	one	one	CD
cord-018764-02l423mk	63	19	containing	containing	NN
cord-018764-02l423mk	63	20	,	,	,
cord-018764-02l423mk	63	21	from	from	IN
cord-018764-02l423mk	63	22	its	-PRON-	PRP$
cord-018764-02l423mk	63	23	beginning	beginning	NN
cord-018764-02l423mk	63	24	,	,	,
cord-018764-02l423mk	63	25	an	an	DT
cord-018764-02l423mk	63	26	unresolved	unresolved	JJ
cord-018764-02l423mk	63	27	tension	tension	NN
cord-018764-02l423mk	63	28	.	.	.
cord-018764-02l423mk	64	1	Vascular	vascular	JJ
cord-018764-02l423mk	64	2	occlusion	occlusion	NN
cord-018764-02l423mk	64	3	and	and	CC
cord-018764-02l423mk	64	4	malarial	malarial	JJ
cord-018764-02l423mk	64	5	toxin	toxin	NN
cord-018764-02l423mk	64	6	(	(	-LRB-
cord-018764-02l423mk	64	7	nowadays	nowadays	RB
cord-018764-02l423mk	64	8	vascular	vascular	JJ
cord-018764-02l423mk	64	9	occlusion	occlusion	NN
cord-018764-02l423mk	64	10	and	and	CC
cord-018764-02l423mk	64	11	inflammatory	inflammatory	JJ
cord-018764-02l423mk	64	12	cytokines	cytokine	NNS
cord-018764-02l423mk	64	13	)	)	-RRB-
cord-018764-02l423mk	64	14	have	have	VBP
cord-018764-02l423mk	64	15	been	be	VBN
cord-018764-02l423mk	64	16	alternative	alternative	JJ
cord-018764-02l423mk	64	17	approaches	approach	NNS
cord-018764-02l423mk	64	18	to	to	IN
cord-018764-02l423mk	64	19	understanding	understand	VBG
cord-018764-02l423mk	64	20	malarial	malarial	JJ
cord-018764-02l423mk	64	21	disease	disease	NN
cord-018764-02l423mk	64	22	as	as	IN
cord-018764-02l423mk	64	23	a	a	DT
cord-018764-02l423mk	64	24	whole	whole	NN
cord-018764-02l423mk	64	25	,	,	,
cord-018764-02l423mk	64	26	as	as	RB
cord-018764-02l423mk	64	27	well	well	RB
cord-018764-02l423mk	64	28	as	as	IN
cord-018764-02l423mk	64	29	the	the	DT
cord-018764-02l423mk	64	30	coma	coma	NN
cord-018764-02l423mk	64	31	,	,	,
cord-018764-02l423mk	64	32	for	for	IN
cord-018764-02l423mk	64	33	over	over	IN
cord-018764-02l423mk	64	34	a	a	DT
cord-018764-02l423mk	64	35	century	century	NN
cord-018764-02l423mk	64	36	,	,	,
cord-018764-02l423mk	64	37	and	and	CC
cord-018764-02l423mk	64	38	the	the	DT
cord-018764-02l423mk	64	39	two	two	CD
cord-018764-02l423mk	64	40	have	have	VBP
cord-018764-02l423mk	64	41	often	often	RB
cord-018764-02l423mk	64	42	been	be	VBN
cord-018764-02l423mk	64	43	discussed	discuss	VBN
cord-018764-02l423mk	64	44	side	side	NN
cord-018764-02l423mk	64	45	by	by	IN
cord-018764-02l423mk	64	46	side	side	NN
cord-018764-02l423mk	64	47	[	[	-LRB-
cord-018764-02l423mk	64	48	5	5	CD
cord-018764-02l423mk	64	49	,	,	,
cord-018764-02l423mk	64	50	20	20	CD
cord-018764-02l423mk	64	51	,	,	,
cord-018764-02l423mk	64	52	21	21	CD
cord-018764-02l423mk	64	53	]	]	-RRB-
cord-018764-02l423mk	64	54	.	.	.
cord-018764-02l423mk	65	1	The	the	DT
cord-018764-02l423mk	65	2	presence	presence	NN
cord-018764-02l423mk	65	3	of	of	IN
cord-018764-02l423mk	65	4	hyperlactataemia	hyperlactataemia	NNP
cord-018764-02l423mk	65	5	,	,	,
cord-018764-02l423mk	65	6	hypoglycaemia	hypoglycaemia	NN
cord-018764-02l423mk	65	7	,	,	,
cord-018764-02l423mk	65	8	and	and	CC
cord-018764-02l423mk	65	9	metabolic	metabolic	JJ
cord-018764-02l423mk	65	10	acidosis	acidosis	NN
cord-018764-02l423mk	65	11	,	,	,
cord-018764-02l423mk	65	12	all	all	DT
cord-018764-02l423mk	65	13	three	three	CD
cord-018764-02l423mk	65	14	consistent	consistent	JJ
cord-018764-02l423mk	65	15	with	with	IN
cord-018764-02l423mk	65	16	a	a	DT
cord-018764-02l423mk	65	17	patient	patient	NN
cord-018764-02l423mk	65	18	being	be	VBG
cord-018764-02l423mk	65	19	forced	force	VBN
cord-018764-02l423mk	65	20	to	to	TO
cord-018764-02l423mk	65	21	rely	rely	VB
cord-018764-02l423mk	65	22	on	on	IN
cord-018764-02l423mk	65	23	anaerobic	anaerobic	JJ
cord-018764-02l423mk	65	24	glycolysis	glycolysis	NN
cord-018764-02l423mk	65	25	for	for	IN
cord-018764-02l423mk	65	26	energy	energy	NN
cord-018764-02l423mk	65	27	production	production	NN
cord-018764-02l423mk	65	28	,	,	,
cord-018764-02l423mk	65	29	have	have	VBP
cord-018764-02l423mk	65	30	provided	provide	VBN
cord-018764-02l423mk	65	31	a	a	DT
cord-018764-02l423mk	65	32	consensus	consensus	NN
cord-018764-02l423mk	65	33	that	that	IN
cord-018764-02l423mk	65	34	hypoxia	hypoxia	NN
cord-018764-02l423mk	65	35	is	be	VBZ
cord-018764-02l423mk	65	36	central	central	JJ
cord-018764-02l423mk	65	37	to	to	IN
cord-018764-02l423mk	65	38	disease	disease	NN
cord-018764-02l423mk	65	39	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	65	40	in	in	IN
cord-018764-02l423mk	65	41	falciparum	falciparum	NN
cord-018764-02l423mk	65	42	malaria	malaria	NN
cord-018764-02l423mk	65	43	.	.	.
cord-018764-02l423mk	66	1	As	as	IN
cord-018764-02l423mk	66	2	sum	sum	NN
cord-018764-02l423mk	66	3	-	-	HYPH
cord-018764-02l423mk	66	4	marised	marise	VBN
cord-018764-02l423mk	66	5	below	below	RB
cord-018764-02l423mk	66	6	,	,	,
cord-018764-02l423mk	66	7	the	the	DT
cord-018764-02l423mk	66	8	modern	modern	JJ
cord-018764-02l423mk	66	9	literature	literature	NN
cord-018764-02l423mk	66	10	offers	offer	VBZ
cord-018764-02l423mk	66	11	two	two	CD
cord-018764-02l423mk	66	12	main	main	JJ
cord-018764-02l423mk	66	13	theories	theory	NNS
cord-018764-02l423mk	66	14	for	for	IN
cord-018764-02l423mk	66	15	cellular	cellular	JJ
cord-018764-02l423mk	66	16	hypoxia	hypoxia	NN
cord-018764-02l423mk	66	17	during	during	IN
cord-018764-02l423mk	66	18	infection	infection	NN
cord-018764-02l423mk	66	19	;	;	,
cord-018764-02l423mk	66	20	insufficient	insufficient	JJ
cord-018764-02l423mk	66	21	oxygen	oxygen	NN
cord-018764-02l423mk	66	22	delivery	delivery	NN
cord-018764-02l423mk	66	23	to	to	IN
cord-018764-02l423mk	66	24	cells	cell	NNS
cord-018764-02l423mk	66	25	and	and	CC
cord-018764-02l423mk	66	26	impaired	impair	VBN
cord-018764-02l423mk	66	27	oxygen	oxygen	NN
cord-018764-02l423mk	66	28	utilization	utilization	NN
cord-018764-02l423mk	66	29	within	within	IN
cord-018764-02l423mk	66	30	the	the	DT
cord-018764-02l423mk	66	31	cells	cell	NNS
cord-018764-02l423mk	66	32	.	.	.
cord-018764-02l423mk	67	1	Both	both	DT
cord-018764-02l423mk	67	2	mechanisms	mechanism	NNS
cord-018764-02l423mk	67	3	may	may	MD
cord-018764-02l423mk	67	4	be	be	VB
cord-018764-02l423mk	67	5	governed	govern	VBN
cord-018764-02l423mk	67	6	by	by	IN
cord-018764-02l423mk	67	7	the	the	DT
cord-018764-02l423mk	67	8	host	host	NN
cord-018764-02l423mk	67	9	inflammatory	inflammatory	JJ
cord-018764-02l423mk	67	10	cytokine	cytokine	NN
cord-018764-02l423mk	67	11	response	response	NN
cord-018764-02l423mk	67	12	to	to	IN
cord-018764-02l423mk	67	13	infection	infection	NN
cord-018764-02l423mk	67	14	.	.	.
cord-018764-02l423mk	68	1	This	this	DT
cord-018764-02l423mk	68	2	chapter	chapter	NN
cord-018764-02l423mk	68	3	focuses	focus	VBZ
cord-018764-02l423mk	68	4	on	on	IN
cord-018764-02l423mk	68	5	how	how	WRB
cord-018764-02l423mk	68	6	an	an	DT
cord-018764-02l423mk	68	7	increased	increased	JJ
cord-018764-02l423mk	68	8	understanding	understanding	NN
cord-018764-02l423mk	68	9	of	of	IN
cord-018764-02l423mk	68	10	the	the	DT
cord-018764-02l423mk	68	11	molecular	molecular	JJ
cord-018764-02l423mk	68	12	functions	function	NNS
cord-018764-02l423mk	68	13	of	of	IN
cord-018764-02l423mk	68	14	cytokines	cytokine	NNS
cord-018764-02l423mk	68	15	during	during	IN
cord-018764-02l423mk	68	16	disease	disease	NN
cord-018764-02l423mk	68	17	demonstrates	demonstrate	VBZ
cord-018764-02l423mk	68	18	a	a	DT
cord-018764-02l423mk	68	19	closer	close	JJR
cord-018764-02l423mk	68	20	alignment	alignment	NN
cord-018764-02l423mk	68	21	between	between	IN
cord-018764-02l423mk	68	22	the	the	DT
cord-018764-02l423mk	68	23	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	68	24	of	of	IN
cord-018764-02l423mk	68	25	falciparum	falciparum	NN
cord-018764-02l423mk	68	26	infection	infection	NN
cord-018764-02l423mk	68	27	and	and	CC
cord-018764-02l423mk	68	28	other	other	JJ
cord-018764-02l423mk	68	29	systemic	systemic	JJ
cord-018764-02l423mk	68	30	infectious	infectious	JJ
cord-018764-02l423mk	68	31	diseases	disease	NNS
cord-018764-02l423mk	68	32	.	.	.
cord-018764-02l423mk	69	1	One	one	CD
cord-018764-02l423mk	69	2	hundred	hundred	CD
cord-018764-02l423mk	69	3	and	and	CC
cord-018764-02l423mk	69	4	twenty	twenty	CD
cord-018764-02l423mk	69	5	years	year	NNS
cord-018764-02l423mk	69	6	ago	ago	RB
cord-018764-02l423mk	69	7	,	,	,
cord-018764-02l423mk	69	8	Golgi	Golgi	NNP
cord-018764-02l423mk	69	9	(	(	-LRB-
cord-018764-02l423mk	69	10	of	of	IN
cord-018764-02l423mk	69	11	the	the	DT
cord-018764-02l423mk	69	12	Golgi	Golgi	NNP
cord-018764-02l423mk	69	13	apparatus	apparatus	NN
cord-018764-02l423mk	69	14	[	[	-LRB-
cord-018764-02l423mk	69	15	22	22	CD
cord-018764-02l423mk	69	16	]	]	-RRB-
cord-018764-02l423mk	69	17	)	)	-RRB-
cord-018764-02l423mk	69	18	,	,	,
cord-018764-02l423mk	69	19	noted	note	VBD
cord-018764-02l423mk	69	20	onset	onset	NN
cord-018764-02l423mk	69	21	of	of	IN
cord-018764-02l423mk	69	22	malarial	malarial	JJ
cord-018764-02l423mk	69	23	fever	fever	NN
cord-018764-02l423mk	69	24	and	and	CC
cord-018764-02l423mk	69	25	illness	illness	NN
cord-018764-02l423mk	69	26	at	at	IN
cord-018764-02l423mk	69	27	a	a	DT
cord-018764-02l423mk	69	28	predictable	predictable	JJ
cord-018764-02l423mk	69	29	short	short	JJ
cord-018764-02l423mk	69	30	interval	interval	NN
cord-018764-02l423mk	69	31	after	after	IN
cord-018764-02l423mk	69	32	the	the	DT
cord-018764-02l423mk	69	33	regular	regular	JJ
cord-018764-02l423mk	69	34	shower	shower	NN
cord-018764-02l423mk	69	35	of	of	IN
cord-018764-02l423mk	69	36	new	new	JJ
cord-018764-02l423mk	69	37	parasites	parasite	NNS
cord-018764-02l423mk	69	38	were	be	VBD
cord-018764-02l423mk	69	39	released	release	VBN
cord-018764-02l423mk	69	40	from	from	IN
cord-018764-02l423mk	69	41	bursting	burst	VBG
cord-018764-02l423mk	69	42	red	red	JJ
cord-018764-02l423mk	69	43	cells	cell	NNS
cord-018764-02l423mk	69	44	.	.	.
cord-018764-02l423mk	70	1	The	the	DT
cord-018764-02l423mk	70	2	nature	nature	NN
cord-018764-02l423mk	70	3	of	of	IN
cord-018764-02l423mk	70	4	the	the	DT
cord-018764-02l423mk	70	5	putative	putative	JJ
cord-018764-02l423mk	70	6	toxin	toxin	NN
cord-018764-02l423mk	70	7	so	so	RB
cord-018764-02l423mk	70	8	released	release	VBN
cord-018764-02l423mk	70	9	was	be	VBD
cord-018764-02l423mk	70	10	much	much	RB
cord-018764-02l423mk	70	11	discussed	discuss	VBN
cord-018764-02l423mk	70	12	in	in	IN
cord-018764-02l423mk	70	13	the	the	DT
cord-018764-02l423mk	70	14	first	first	JJ
cord-018764-02l423mk	70	15	decade	decade	NN
cord-018764-02l423mk	70	16	of	of	IN
cord-018764-02l423mk	70	17	the	the	DT
cord-018764-02l423mk	70	18	20th	20th	JJ
cord-018764-02l423mk	70	19	century	century	NN
cord-018764-02l423mk	70	20	[	[	-LRB-
cord-018764-02l423mk	70	21	23	23	CD
cord-018764-02l423mk	70	22	]	]	-RRB-
cord-018764-02l423mk	70	23	.	.	.
cord-018764-02l423mk	71	1	It	-PRON-	PRP
cord-018764-02l423mk	71	2	was	be	VBD
cord-018764-02l423mk	71	3	assumed	assume	VBN
cord-018764-02l423mk	71	4	to	to	TO
cord-018764-02l423mk	71	5	be	be	VB
cord-018764-02l423mk	71	6	directly	directly	RB
cord-018764-02l423mk	71	7	toxic	toxic	JJ
cord-018764-02l423mk	71	8	,	,	,
cord-018764-02l423mk	71	9	in	in	IN
cord-018764-02l423mk	71	10	the	the	DT
cord-018764-02l423mk	71	11	manner	manner	NN
cord-018764-02l423mk	71	12	of	of	IN
cord-018764-02l423mk	71	13	tetanus	tetanus	JJ
cord-018764-02l423mk	71	14	toxin	toxin	NN
cord-018764-02l423mk	71	15	.	.	.
cord-018764-02l423mk	72	1	The	the	DT
cord-018764-02l423mk	72	2	proposal	proposal	NN
cord-018764-02l423mk	72	3	that	that	IN
cord-018764-02l423mk	72	4	malarial	malarial	JJ
cord-018764-02l423mk	72	5	products	product	NNS
cord-018764-02l423mk	72	6	were	be	VBD
cord-018764-02l423mk	72	7	not	not	RB
cord-018764-02l423mk	72	8	harmful	harmful	JJ
cord-018764-02l423mk	72	9	in	in	IN
cord-018764-02l423mk	72	10	themselves	-PRON-	PRP
cord-018764-02l423mk	72	11	,	,	,
cord-018764-02l423mk	72	12	but	but	CC
cord-018764-02l423mk	72	13	only	only	RB
cord-018764-02l423mk	72	14	through	through	IN
cord-018764-02l423mk	72	15	causing	cause	VBG
cord-018764-02l423mk	72	16	the	the	DT
cord-018764-02l423mk	72	17	infected	infected	JJ
cord-018764-02l423mk	72	18	host	host	NN
cord-018764-02l423mk	72	19	to	to	TO
cord-018764-02l423mk	72	20	harm	harm	VB
cord-018764-02l423mk	72	21	itself	-PRON-	PRP
cord-018764-02l423mk	72	22	through	through	IN
cord-018764-02l423mk	72	23	generating	generate	VBG
cord-018764-02l423mk	72	24	toxic	toxic	JJ
cord-018764-02l423mk	72	25	amounts	amount	NNS
cord-018764-02l423mk	72	26	of	of	IN
cord-018764-02l423mk	72	27	molecules	molecule	NNS
cord-018764-02l423mk	72	28	(	(	-LRB-
cord-018764-02l423mk	72	29	pro	pro	JJ
cord-018764-02l423mk	72	30	-	-	JJ
cord-018764-02l423mk	72	31	inflammatory	inflammatory	JJ
cord-018764-02l423mk	72	32	cytokines	cytokine	NNS
cord-018764-02l423mk	72	33	)	)	-RRB-
cord-018764-02l423mk	72	34	that	that	IN
cord-018764-02l423mk	72	35	,	,	,
cord-018764-02l423mk	72	36	in	in	IN
cord-018764-02l423mk	72	37	lower	low	JJR
cord-018764-02l423mk	72	38	concentrations	concentration	NNS
cord-018764-02l423mk	72	39	,	,	,
cord-018764-02l423mk	72	40	inhibit	inhibit	VBP
cord-018764-02l423mk	72	41	growth	growth	NN
cord-018764-02l423mk	72	42	of	of	IN
cord-018764-02l423mk	72	43	malarial	malarial	JJ
cord-018764-02l423mk	72	44	parasites	parasite	NNS
cord-018764-02l423mk	72	45	did	do	VBD
cord-018764-02l423mk	72	46	not	not	RB
cord-018764-02l423mk	72	47	arise	arise	VB
cord-018764-02l423mk	72	48	until	until	IN
cord-018764-02l423mk	72	49	1981	1981	CD
cord-018764-02l423mk	72	50	[	[	-LRB-
cord-018764-02l423mk	72	51	24	24	CD
cord-018764-02l423mk	72	52	]	]	-RRB-
cord-018764-02l423mk	72	53	.	.	.
cord-018764-02l423mk	73	1	Indeed	indeed	RB
cord-018764-02l423mk	73	2	,	,	,
cord-018764-02l423mk	73	3	acceptance	acceptance	NN
cord-018764-02l423mk	73	4	of	of	IN
cord-018764-02l423mk	73	5	the	the	DT
cord-018764-02l423mk	73	6	broad	broad	JJ
cord-018764-02l423mk	73	7	applicability	applicability	NN
cord-018764-02l423mk	73	8	of	of	IN
cord-018764-02l423mk	73	9	this	this	DT
cord-018764-02l423mk	73	10	concept	concept	NN
cord-018764-02l423mk	73	11	to	to	IN
cord-018764-02l423mk	73	12	infectious	infectious	JJ
cord-018764-02l423mk	73	13	disease	disease	NN
cord-018764-02l423mk	73	14	in	in	IN
cord-018764-02l423mk	73	15	general	general	JJ
cord-018764-02l423mk	73	16	is	be	VBZ
cord-018764-02l423mk	73	17	now	now	RB
cord-018764-02l423mk	73	18	sufficient	sufficient	JJ
cord-018764-02l423mk	73	19	for	for	IN
cord-018764-02l423mk	73	20	its	-PRON-	PRP$
cord-018764-02l423mk	73	21	evolution	evolution	NN
cord-018764-02l423mk	73	22	to	to	TO
cord-018764-02l423mk	73	23	be	be	VB
cord-018764-02l423mk	73	24	a	a	DT
cord-018764-02l423mk	73	25	subject	subject	NN
cord-018764-02l423mk	73	26	for	for	IN
cord-018764-02l423mk	73	27	research	research	NN
cord-018764-02l423mk	73	28	[	[	-LRB-
cord-018764-02l423mk	73	29	25	25	CD
cord-018764-02l423mk	73	30	]	]	-RRB-
cord-018764-02l423mk	73	31	.	.	.
cord-018764-02l423mk	74	1	Tumour	tumour	NN
cord-018764-02l423mk	74	2	necrosis	necrosis	NN
cord-018764-02l423mk	74	3	factor	factor	NN
cord-018764-02l423mk	74	4	(	(	-LRB-
cord-018764-02l423mk	74	5	TNF	TNF	NNP
cord-018764-02l423mk	74	6	)	)	-RRB-
cord-018764-02l423mk	74	7	is	be	VBZ
cord-018764-02l423mk	74	8	regarded	regard	VBN
cord-018764-02l423mk	74	9	as	as	IN
cord-018764-02l423mk	74	10	a	a	DT
cord-018764-02l423mk	74	11	major	major	JJ
cord-018764-02l423mk	74	12	player	player	NN
cord-018764-02l423mk	74	13	,	,	,
cord-018764-02l423mk	74	14	malaria	malaria	NN
cord-018764-02l423mk	74	15	being	be	VBG
cord-018764-02l423mk	74	16	the	the	DT
cord-018764-02l423mk	74	17	first	first	JJ
cord-018764-02l423mk	74	18	disease	disease	NN
cord-018764-02l423mk	74	19	in	in	IN
cord-018764-02l423mk	74	20	which	which	WDT
cord-018764-02l423mk	74	21	it	-PRON-	PRP
cord-018764-02l423mk	74	22	was	be	VBD
cord-018764-02l423mk	74	23	proposed	propose	VBN
cord-018764-02l423mk	74	24	to	to	TO
cord-018764-02l423mk	74	25	cause	cause	VB
cord-018764-02l423mk	74	26	systemic	systemic	JJ
cord-018764-02l423mk	74	27	illness	illness	NN
cord-018764-02l423mk	74	28	and	and	CC
cord-018764-02l423mk	74	29	pathology	pathology	NN
cord-018764-02l423mk	74	30	[	[	-LRB-
cord-018764-02l423mk	74	31	24	24	CD
cord-018764-02l423mk	74	32	]	]	-RRB-
cord-018764-02l423mk	74	33	.	.	.
cord-018764-02l423mk	75	1	Multiple	multiple	JJ
cord-018764-02l423mk	75	2	TNF	TNF	NNP
cord-018764-02l423mk	75	3	promoter	promoter	NN
cord-018764-02l423mk	75	4	polymorphisms	polymorphism	NNS
cord-018764-02l423mk	75	5	have	have	VBP
cord-018764-02l423mk	75	6	since	since	IN
cord-018764-02l423mk	75	7	been	be	VBN
cord-018764-02l423mk	75	8	independently	independently	RB
cord-018764-02l423mk	75	9	associated	associate	VBN
cord-018764-02l423mk	75	10	with	with	IN
cord-018764-02l423mk	75	11	severe	severe	JJ
cord-018764-02l423mk	75	12	malaria	malaria	NN
cord-018764-02l423mk	75	13	across	across	IN
cord-018764-02l423mk	75	14	several	several	JJ
cord-018764-02l423mk	75	15	geographical	geographical	JJ
cord-018764-02l423mk	75	16	populations	population	NNS
cord-018764-02l423mk	75	17	[	[	-LRB-
cord-018764-02l423mk	75	18	26	26	CD
cord-018764-02l423mk	75	19	]	]	-RRB-
cord-018764-02l423mk	75	20	.	.	.
cord-018764-02l423mk	76	1	A	a	DT
cord-018764-02l423mk	76	2	longitudinal	longitudinal	JJ
cord-018764-02l423mk	76	3	study	study	NN
cord-018764-02l423mk	76	4	in	in	IN
cord-018764-02l423mk	76	5	Burkino	Burkino	NNP
cord-018764-02l423mk	76	6	Faso	Faso	NNP
cord-018764-02l423mk	76	7	has	have	VBZ
cord-018764-02l423mk	76	8	also	also	RB
cord-018764-02l423mk	76	9	demonstrated	demonstrate	VBN
cord-018764-02l423mk	76	10	several	several	JJ
cord-018764-02l423mk	76	11	TNF	TNF	NNP
cord-018764-02l423mk	76	12	promoter	promoter	NN
cord-018764-02l423mk	76	13	polymorphisms	polymorphism	NNS
cord-018764-02l423mk	76	14	associated	associate	VBN
cord-018764-02l423mk	76	15	with	with	IN
cord-018764-02l423mk	76	16	the	the	DT
cord-018764-02l423mk	76	17	regulation	regulation	NN
cord-018764-02l423mk	76	18	of	of	IN
cord-018764-02l423mk	76	19	host	host	NN
cord-018764-02l423mk	76	20	-	-	HYPH
cord-018764-02l423mk	76	21	parasite	parasite	NN
cord-018764-02l423mk	76	22	density	density	NN
cord-018764-02l423mk	76	23	[	[	-LRB-
cord-018764-02l423mk	76	24	27	27	CD
cord-018764-02l423mk	76	25	]	]	-RRB-
cord-018764-02l423mk	76	26	.	.	.
cord-018764-02l423mk	77	1	The	the	DT
cord-018764-02l423mk	77	2	TNF	TNF	NNP
cord-018764-02l423mk	77	3	concept	concept	NN
cord-018764-02l423mk	77	4	has	have	VBZ
cord-018764-02l423mk	77	5	since	since	IN
cord-018764-02l423mk	77	6	begun	begin	VBN
cord-018764-02l423mk	77	7	to	to	TO
cord-018764-02l423mk	77	8	dominate	dominate	VB
cord-018764-02l423mk	77	9	the	the	DT
cord-018764-02l423mk	77	10	sepsis	sepsis	NN
cord-018764-02l423mk	77	11	literature	literature	NN
cord-018764-02l423mk	77	12	[	[	-LRB-
cord-018764-02l423mk	77	13	28	28	CD
cord-018764-02l423mk	77	14	]	]	-RRB-
cord-018764-02l423mk	77	15	,	,	,
cord-018764-02l423mk	77	16	and	and	CC
cord-018764-02l423mk	77	17	the	the	DT
cord-018764-02l423mk	77	18	virulence	virulence	NN
cord-018764-02l423mk	77	19	of	of	IN
cord-018764-02l423mk	77	20	different	different	JJ
cord-018764-02l423mk	77	21	strains	strain	NNS
cord-018764-02l423mk	77	22	of	of	IN
cord-018764-02l423mk	77	23	influenza	influenza	NN
cord-018764-02l423mk	77	24	,	,	,
cord-018764-02l423mk	77	25	a	a	DT
cord-018764-02l423mk	77	26	disease	disease	NN
cord-018764-02l423mk	77	27	that	that	WDT
cord-018764-02l423mk	77	28	is	be	VBZ
cord-018764-02l423mk	77	29	a	a	DT
cord-018764-02l423mk	77	30	standard	standard	JJ
cord-018764-02l423mk	77	31	clinical	clinical	JJ
cord-018764-02l423mk	77	32	misdiagnosis	misdiagnosis	NN
cord-018764-02l423mk	77	33	for	for	IN
cord-018764-02l423mk	77	34	imported	import	VBN
cord-018764-02l423mk	77	35	malaria	malaria	NN
cord-018764-02l423mk	77	36	,	,	,
cord-018764-02l423mk	77	37	has	have	VBZ
cord-018764-02l423mk	77	38	recently	recently	RB
cord-018764-02l423mk	77	39	been	be	VBN
cord-018764-02l423mk	77	40	expressed	express	VBN
cord-018764-02l423mk	77	41	in	in	IN
cord-018764-02l423mk	77	42	terms	term	NNS
cord-018764-02l423mk	77	43	of	of	IN
cord-018764-02l423mk	77	44	their	-PRON-	PRP$
cord-018764-02l423mk	77	45	capacity	capacity	NN
cord-018764-02l423mk	77	46	to	to	TO
cord-018764-02l423mk	77	47	induce	induce	VB
cord-018764-02l423mk	77	48	TNF	TNF	NNP
cord-018764-02l423mk	77	49	[	[	-LRB-
cord-018764-02l423mk	77	50	29	29	CD
cord-018764-02l423mk	77	51	]	]	-RRB-
cord-018764-02l423mk	77	52	.	.	.
cord-018764-02l423mk	78	1	The	the	DT
cord-018764-02l423mk	78	2	critical	critical	JJ
cord-018764-02l423mk	78	3	role	role	NN
cord-018764-02l423mk	78	4	of	of	IN
cord-018764-02l423mk	78	5	TNF	TNF	NNP
cord-018764-02l423mk	78	6	in	in	IN
cord-018764-02l423mk	78	7	both	both	DT
cord-018764-02l423mk	78	8	malaria	malaria	NN
cord-018764-02l423mk	78	9	and	and	CC
cord-018764-02l423mk	78	10	influenza	influenza	NN
cord-018764-02l423mk	78	11	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	78	12	is	be	VBZ
cord-018764-02l423mk	78	13	consistent	consistent	JJ
cord-018764-02l423mk	78	14	with	with	IN
cord-018764-02l423mk	78	15	the	the	DT
cord-018764-02l423mk	78	16	clinical	clinical	JJ
cord-018764-02l423mk	78	17	similarities	similarity	NNS
cord-018764-02l423mk	78	18	between	between	IN
cord-018764-02l423mk	78	19	the	the	DT
cord-018764-02l423mk	78	20	diseases	disease	NNS
cord-018764-02l423mk	78	21	.	.	.
cord-018764-02l423mk	79	1	Indeed	indeed	RB
cord-018764-02l423mk	79	2	,	,	,
cord-018764-02l423mk	79	3	TNF	TNF	NNP
cord-018764-02l423mk	79	4	infusions	infusion	NNS
cord-018764-02l423mk	79	5	in	in	IN
cord-018764-02l423mk	79	6	tumour	tumour	NN
cord-018764-02l423mk	79	7	patients	patient	NNS
cord-018764-02l423mk	79	8	produce	produce	VBP
cord-018764-02l423mk	79	9	side	side	NN
cord-018764-02l423mk	79	10	effects	effect	NNS
cord-018764-02l423mk	79	11	mimicking	mimic	VBG
cord-018764-02l423mk	79	12	both	both	DT
cord-018764-02l423mk	79	13	diseases	disease	NNS
cord-018764-02l423mk	79	14	[	[	-LRB-
cord-018764-02l423mk	79	15	30	30	CD
cord-018764-02l423mk	79	16	]	]	-RRB-
cord-018764-02l423mk	79	17	,	,	,
cord-018764-02l423mk	79	18	as	as	IN
cord-018764-02l423mk	79	19	discussed	discuss	VBN
cord-018764-02l423mk	79	20	below	below	RB
cord-018764-02l423mk	79	21	.	.	.
cord-018764-02l423mk	80	1	Although	although	IN
cord-018764-02l423mk	80	2	TNF	TNF	NNP
cord-018764-02l423mk	80	3	is	be	VBZ
cord-018764-02l423mk	80	4	the	the	DT
cord-018764-02l423mk	80	5	prototype	prototype	NN
cord-018764-02l423mk	80	6	pro	pro	JJ
cord-018764-02l423mk	80	7	-	-	JJ
cord-018764-02l423mk	80	8	inflammatory	inflammatory	JJ
cord-018764-02l423mk	80	9	cytokine	cytokine	NN
cord-018764-02l423mk	80	10	linked	link	VBN
cord-018764-02l423mk	80	11	with	with	IN
cord-018764-02l423mk	80	12	severe	severe	JJ
cord-018764-02l423mk	80	13	malaria	malaria	NN
cord-018764-02l423mk	80	14	,	,	,
cord-018764-02l423mk	80	15	other	other	JJ
cord-018764-02l423mk	80	16	cytokines	cytokine	NNS
cord-018764-02l423mk	80	17	(	(	-LRB-
cord-018764-02l423mk	80	18	and	and	CC
cord-018764-02l423mk	80	19	mediators	mediator	NNS
cord-018764-02l423mk	80	20	)	)	-RRB-
cord-018764-02l423mk	80	21	including	include	VBG
cord-018764-02l423mk	80	22	interferon	interferon	NN
cord-018764-02l423mk	80	23	(	(	-LRB-
cord-018764-02l423mk	80	24	IFN)-	IFN)-	NNP
cord-018764-02l423mk	80	25	[	[	-LRB-
cord-018764-02l423mk	80	26	31	31	CD
cord-018764-02l423mk	80	27	]	]	-RRB-
cord-018764-02l423mk	80	28	,	,	,
cord-018764-02l423mk	80	29	its	-PRON-	PRP$
cord-018764-02l423mk	80	30	corresponding	correspond	VBG
cord-018764-02l423mk	80	31	receptors	receptor	NNS
cord-018764-02l423mk	80	32	IFN	IFN	NNP
cord-018764-02l423mk	80	33	-	-	HYPH
cord-018764-02l423mk	80	34	receptor-1	receptor-1	NNP
cord-018764-02l423mk	80	35	[	[	-LRB-
cord-018764-02l423mk	80	36	32	32	CD
cord-018764-02l423mk	80	37	]	]	-RRB-
cord-018764-02l423mk	80	38	and	and	CC
cord-018764-02l423mk	80	39	IFN	IFN	NNP
cord-018764-02l423mk	80	40	-	-	HYPH
cord-018764-02l423mk	80	41	receptor-1	receptor-1	NNP
cord-018764-02l423mk	80	42	[	[	-LRB-
cord-018764-02l423mk	80	43	33	33	CD
cord-018764-02l423mk	80	44	]	]	-RRB-
cord-018764-02l423mk	80	45	,	,	.
cord-018764-02l423mk	81	1	IL-1	IL-1	NNP
cord-018764-02l423mk	81	2	[	[	-LRB-
cord-018764-02l423mk	81	3	34	34	CD
cord-018764-02l423mk	81	4	]	]	-RRB-
cord-018764-02l423mk	81	5	,	,	,
cord-018764-02l423mk	81	6	IL-4	IL-4	NNP
cord-018764-02l423mk	81	7	[	[	-LRB-
cord-018764-02l423mk	81	8	35	35	CD
cord-018764-02l423mk	81	9	]	]	-RRB-
cord-018764-02l423mk	81	10	and	and	CC
cord-018764-02l423mk	81	11	IL-10	IL-10	NNP
cord-018764-02l423mk	81	12	[	[	-LRB-
cord-018764-02l423mk	81	13	36	36	CD
cord-018764-02l423mk	81	14	]	]	-RRB-
cord-018764-02l423mk	81	15	have	have	VBP
cord-018764-02l423mk	81	16	all	all	DT
cord-018764-02l423mk	81	17	be	be	VB
cord-018764-02l423mk	81	18	identified	identify	VBN
cord-018764-02l423mk	81	19	through	through	IN
cord-018764-02l423mk	81	20	genetic	genetic	JJ
cord-018764-02l423mk	81	21	association	association	NN
cord-018764-02l423mk	81	22	analysis	analysis	NN
cord-018764-02l423mk	81	23	to	to	TO
cord-018764-02l423mk	81	24	be	be	VB
cord-018764-02l423mk	81	25	linked	link	VBN
cord-018764-02l423mk	81	26	with	with	IN
cord-018764-02l423mk	81	27	their	-PRON-	PRP$
cord-018764-02l423mk	81	28	potential	potential	JJ
cord-018764-02l423mk	81	29	regulation	regulation	NN
cord-018764-02l423mk	81	30	of	of	IN
cord-018764-02l423mk	81	31	malarial	malarial	JJ
cord-018764-02l423mk	81	32	disease	disease	NN
cord-018764-02l423mk	81	33	severity	severity	NN
cord-018764-02l423mk	81	34	.	.	.
cord-018764-02l423mk	82	1	All	all	PDT
cord-018764-02l423mk	82	2	the	the	DT
cord-018764-02l423mk	82	3	above	above	JJ
cord-018764-02l423mk	82	4	cytokines	cytokine	NNS
cord-018764-02l423mk	82	5	typically	typically	RB
cord-018764-02l423mk	82	6	act	act	VBP
cord-018764-02l423mk	82	7	as	as	IN
cord-018764-02l423mk	82	8	homeostatic	homeostatic	JJ
cord-018764-02l423mk	82	9	agents	agent	NNS
cord-018764-02l423mk	82	10	,	,	,
cord-018764-02l423mk	82	11	but	but	CC
cord-018764-02l423mk	82	12	can	can	MD
cord-018764-02l423mk	82	13	cause	cause	VB
cord-018764-02l423mk	82	14	pathology	pathology	NN
cord-018764-02l423mk	82	15	if	if	IN
cord-018764-02l423mk	82	16	produced	produce	VBN
cord-018764-02l423mk	82	17	excessively	excessively	RB
cord-018764-02l423mk	82	18	.	.	.
cord-018764-02l423mk	83	1	When	when	WRB
cord-018764-02l423mk	83	2	this	this	DT
cord-018764-02l423mk	83	3	happens	happen	VBZ
cord-018764-02l423mk	83	4	they	-PRON-	PRP
cord-018764-02l423mk	83	5	also	also	RB
cord-018764-02l423mk	83	6	induce	induce	VBP
cord-018764-02l423mk	83	7	a	a	DT
cord-018764-02l423mk	83	8	late	late	JJ
cord-018764-02l423mk	83	9	-	-	HYPH
cord-018764-02l423mk	83	10	onset	onset	NN
cord-018764-02l423mk	83	11	,	,	,
cord-018764-02l423mk	83	12	but	but	CC
cord-018764-02l423mk	83	13	long	long	RB
cord-018764-02l423mk	83	14	-	-	HYPH
cord-018764-02l423mk	83	15	acting	act	VBG
cord-018764-02l423mk	83	16	cytokine	cytokine	NN
cord-018764-02l423mk	83	17	termed	term	VBD
cord-018764-02l423mk	83	18	the	the	DT
cord-018764-02l423mk	83	19	high	high	JJ
cord-018764-02l423mk	83	20	mobility	mobility	NN
cord-018764-02l423mk	83	21	group	group	NN
cord-018764-02l423mk	83	22	box	box	NN
cord-018764-02l423mk	83	23	1	1	CD
cord-018764-02l423mk	83	24	(	(	-LRB-
cord-018764-02l423mk	83	25	HMGB1	HMGB1	NNP
cord-018764-02l423mk	83	26	)	)	-RRB-
cord-018764-02l423mk	83	27	protein	protein	NN
cord-018764-02l423mk	83	28	,	,	,
cord-018764-02l423mk	83	29	which	which	WDT
cord-018764-02l423mk	83	30	prolongs	prolong	VBZ
cord-018764-02l423mk	83	31	and	and	CC
cord-018764-02l423mk	83	32	amplifies	amplify	VBZ
cord-018764-02l423mk	83	33	inflammation	inflammation	NN
cord-018764-02l423mk	83	34	[	[	-LRB-
cord-018764-02l423mk	83	35	37	37	CD
cord-018764-02l423mk	83	36	,	,	,
cord-018764-02l423mk	83	37	38	38	CD
cord-018764-02l423mk	83	38	]	]	-RRB-
cord-018764-02l423mk	83	39	.	.	.
cord-018764-02l423mk	84	1	This	this	DT
cord-018764-02l423mk	84	2	molecule	molecule	NN
cord-018764-02l423mk	84	3	,	,	,
cord-018764-02l423mk	84	4	normally	normally	RB
cord-018764-02l423mk	84	5	in	in	IN
cord-018764-02l423mk	84	6	the	the	DT
cord-018764-02l423mk	84	7	cellular	cellular	JJ
cord-018764-02l423mk	84	8	nucleus	nucleus	NN
cord-018764-02l423mk	84	9	and	and	CC
cord-018764-02l423mk	84	10	previously	previously	RB
cord-018764-02l423mk	84	11	known	know	VBN
cord-018764-02l423mk	84	12	only	only	RB
cord-018764-02l423mk	84	13	for	for	IN
cord-018764-02l423mk	84	14	several	several	JJ
cord-018764-02l423mk	84	15	physiological	physiological	JJ
cord-018764-02l423mk	84	16	functions	function	NNS
cord-018764-02l423mk	84	17	,	,	,
cord-018764-02l423mk	84	18	now	now	RB
cord-018764-02l423mk	84	19	shows	show	VBZ
cord-018764-02l423mk	84	20	great	great	JJ
cord-018764-02l423mk	84	21	promise	promise	NN
cord-018764-02l423mk	84	22	as	as	IN
cord-018764-02l423mk	84	23	a	a	DT
cord-018764-02l423mk	84	24	therapeutic	therapeutic	JJ
cord-018764-02l423mk	84	25	target	target	NN
cord-018764-02l423mk	84	26	in	in	IN
cord-018764-02l423mk	84	27	sepsis	sepsis	NN
cord-018764-02l423mk	84	28	,	,	,
cord-018764-02l423mk	84	29	in	in	IN
cord-018764-02l423mk	84	30	that	that	DT
cord-018764-02l423mk	84	31	countering	counter	VBG
cord-018764-02l423mk	84	32	it	-PRON-	PRP
cord-018764-02l423mk	84	33	after	after	IN
cord-018764-02l423mk	84	34	the	the	DT
cord-018764-02l423mk	84	35	onset	onset	NN
cord-018764-02l423mk	84	36	of	of	IN
cord-018764-02l423mk	84	37	illness	illness	NN
cord-018764-02l423mk	84	38	protects	protect	VBZ
cord-018764-02l423mk	84	39	well	well	RB
cord-018764-02l423mk	84	40	in	in	IN
cord-018764-02l423mk	84	41	experimental	experimental	JJ
cord-018764-02l423mk	84	42	sepsis	sepsis	NN
cord-018764-02l423mk	84	43	[	[	-LRB-
cord-018764-02l423mk	84	44	39	39	CD
cord-018764-02l423mk	84	45	,	,	,
cord-018764-02l423mk	84	46	40	40	CD
cord-018764-02l423mk	84	47	]	]	-RRB-
cord-018764-02l423mk	84	48	.	.	.
cord-018764-02l423mk	85	1	It	-PRON-	PRP
cord-018764-02l423mk	85	2	accumulates	accumulate	VBZ
cord-018764-02l423mk	85	3	,	,	,
cord-018764-02l423mk	85	4	in	in	IN
cord-018764-02l423mk	85	5	proportion	proportion	NN
cord-018764-02l423mk	85	6	to	to	IN
cord-018764-02l423mk	85	7	degree	degree	NN
cord-018764-02l423mk	85	8	of	of	IN
cord-018764-02l423mk	85	9	illness	illness	NN
cord-018764-02l423mk	85	10	,	,	,
cord-018764-02l423mk	85	11	in	in	IN
cord-018764-02l423mk	85	12	serum	serum	NN
cord-018764-02l423mk	85	13	from	from	IN
cord-018764-02l423mk	85	14	African	african	JJ
cord-018764-02l423mk	85	15	children	child	NNS
cord-018764-02l423mk	85	16	infected	infect	VBN
cord-018764-02l423mk	85	17	with	with	IN
cord-018764-02l423mk	85	18	falciparum	falciparum	NN
cord-018764-02l423mk	85	19	malaria	malaria	NN
cord-018764-02l423mk	85	20	[	[	-LRB-
cord-018764-02l423mk	85	21	41	41	CD
cord-018764-02l423mk	85	22	]	]	-RRB-
cord-018764-02l423mk	85	23	.	.	.
cord-018764-02l423mk	86	1	Once	once	RB
cord-018764-02l423mk	86	2	neutralising	neutralise	VBG
cord-018764-02l423mk	86	3	anti	anti	JJ
cord-018764-02l423mk	86	4	-	-	JJ
cord-018764-02l423mk	86	5	TNF	TNF	NNP
cord-018764-02l423mk	86	6	antibodies	antibody	NNS
cord-018764-02l423mk	86	7	became	become	VBD
cord-018764-02l423mk	86	8	available	available	JJ
cord-018764-02l423mk	86	9	for	for	IN
cord-018764-02l423mk	86	10	human	human	JJ
cord-018764-02l423mk	86	11	use	use	NN
cord-018764-02l423mk	86	12	,	,	,
cord-018764-02l423mk	86	13	they	-PRON-	PRP
cord-018764-02l423mk	86	14	were	be	VBD
cord-018764-02l423mk	86	15	tested	test	VBN
cord-018764-02l423mk	86	16	for	for	IN
cord-018764-02l423mk	86	17	efficacy	efficacy	NN
cord-018764-02l423mk	86	18	against	against	IN
cord-018764-02l423mk	86	19	malarial	malarial	JJ
cord-018764-02l423mk	86	20	disease	disease	NN
cord-018764-02l423mk	86	21	.	.	.
cord-018764-02l423mk	87	1	Unfortunately	unfortunately	RB
cord-018764-02l423mk	87	2	,	,	,
cord-018764-02l423mk	87	3	a	a	DT
cord-018764-02l423mk	87	4	central	central	JJ
cord-018764-02l423mk	87	5	tenet	tenet	NN
cord-018764-02l423mk	87	6	of	of	IN
cord-018764-02l423mk	87	7	the	the	DT
cord-018764-02l423mk	87	8	cytokine	cytokine	NN
cord-018764-02l423mk	87	9	concept	concept	NN
cord-018764-02l423mk	87	10	of	of	IN
cord-018764-02l423mk	87	11	infectious	infectious	JJ
cord-018764-02l423mk	87	12	disease	disease	NN
cord-018764-02l423mk	87	13	(	(	-LRB-
cord-018764-02l423mk	87	14	that	that	IN
cord-018764-02l423mk	87	15	the	the	DT
cord-018764-02l423mk	87	16	proinflammatory	proinflammatory	JJ
cord-018764-02l423mk	87	17	cytokines	cytokine	NNS
cord-018764-02l423mk	87	18	that	that	WDT
cord-018764-02l423mk	87	19	cause	cause	VBP
cord-018764-02l423mk	87	20	disease	disease	NN
cord-018764-02l423mk	87	21	are	be	VBP
cord-018764-02l423mk	87	22	the	the	DT
cord-018764-02l423mk	87	23	same	same	JJ
cord-018764-02l423mk	87	24	mediators	mediator	NNS
cord-018764-02l423mk	87	25	that	that	WDT
cord-018764-02l423mk	87	26	,	,	,
cord-018764-02l423mk	87	27	in	in	IN
cord-018764-02l423mk	87	28	lower	low	JJR
cord-018764-02l423mk	87	29	concentrations	concentration	NNS
cord-018764-02l423mk	87	30	,	,	,
cord-018764-02l423mk	87	31	are	be	VBP
cord-018764-02l423mk	87	32	responsible	responsible	JJ
cord-018764-02l423mk	87	33	for	for	IN
cord-018764-02l423mk	87	34	the	the	DT
cord-018764-02l423mk	87	35	innate	innate	JJ
cord-018764-02l423mk	87	36	immunity	immunity	NN
cord-018764-02l423mk	87	37	that	that	WDT
cord-018764-02l423mk	87	38	controls	control	VBZ
cord-018764-02l423mk	87	39	parasite	parasite	NN
cord-018764-02l423mk	87	40	growth	growth	NN
cord-018764-02l423mk	87	41	)	)	-RRB-
cord-018764-02l423mk	87	42	was	be	VBD
cord-018764-02l423mk	87	43	not	not	RB
cord-018764-02l423mk	87	44	taken	take	VBN
cord-018764-02l423mk	87	45	into	into	IN
cord-018764-02l423mk	87	46	consideration	consideration	NN
cord-018764-02l423mk	87	47	.	.	.
cord-018764-02l423mk	88	1	TNF	TNF	NNP
cord-018764-02l423mk	88	2	has	have	VBZ
cord-018764-02l423mk	88	3	been	be	VBN
cord-018764-02l423mk	88	4	shown	show	VBN
cord-018764-02l423mk	88	5	to	to	TO
cord-018764-02l423mk	88	6	inhibit	inhibit	VB
cord-018764-02l423mk	88	7	a	a	DT
cord-018764-02l423mk	88	8	mouse	mouse	NN
cord-018764-02l423mk	88	9	malarial	malarial	JJ
cord-018764-02l423mk	88	10	parasite	parasite	NN
cord-018764-02l423mk	88	11	in	in	IN
cord-018764-02l423mk	88	12	vivo	vivo	NN
cord-018764-02l423mk	88	13	[	[	-LRB-
cord-018764-02l423mk	88	14	42	42	CD
cord-018764-02l423mk	88	15	]	]	-RRB-
cord-018764-02l423mk	88	16	,	,	,
cord-018764-02l423mk	88	17	and	and	CC
cord-018764-02l423mk	88	18	P.	P.	NNP
cord-018764-02l423mk	88	19	falciparum	falciparum	NN
cord-018764-02l423mk	88	20	in	in	IN
cord-018764-02l423mk	88	21	vitro	vitro	FW
cord-018764-02l423mk	88	22	,	,	,
cord-018764-02l423mk	88	23	provided	provide	VBD
cord-018764-02l423mk	88	24	white	white	JJ
cord-018764-02l423mk	88	25	cells	cell	NNS
cord-018764-02l423mk	88	26	to	to	TO
cord-018764-02l423mk	88	27	generate	generate	VB
cord-018764-02l423mk	88	28	the	the	DT
cord-018764-02l423mk	88	29	next	next	JJ
cord-018764-02l423mk	88	30	down	down	JJ
cord-018764-02l423mk	88	31	-	-	HYPH
cord-018764-02l423mk	88	32	stream	stream	NN
cord-018764-02l423mk	88	33	mediator	mediator	NN
cord-018764-02l423mk	88	34	,	,	,
cord-018764-02l423mk	88	35	possibly	possibly	RB
cord-018764-02l423mk	88	36	nitric	nitric	JJ
cord-018764-02l423mk	88	37	oxide	oxide	NN
cord-018764-02l423mk	88	38	(	(	-LRB-
cord-018764-02l423mk	88	39	NO	no	RB
cord-018764-02l423mk	88	40	)	)	-RRB-
cord-018764-02l423mk	88	41	[	[	-LRB-
cord-018764-02l423mk	88	42	43	43	CD
cord-018764-02l423mk	88	43	]	]	-RRB-
cord-018764-02l423mk	88	44	,	,	,
cord-018764-02l423mk	88	45	were	be	VBD
cord-018764-02l423mk	88	46	present	present	JJ
cord-018764-02l423mk	88	47	[	[	-LRB-
cord-018764-02l423mk	88	48	44	44	CD
cord-018764-02l423mk	88	49	]	]	-RRB-
cord-018764-02l423mk	88	50	.	.	.
cord-018764-02l423mk	89	1	This	this	DT
cord-018764-02l423mk	89	2	is	be	VBZ
cord-018764-02l423mk	89	3	consistent	consistent	JJ
cord-018764-02l423mk	89	4	with	with	IN
cord-018764-02l423mk	89	5	findings	finding	NNS
cord-018764-02l423mk	89	6	in	in	IN
cord-018764-02l423mk	89	7	human	human	JJ
cord-018764-02l423mk	89	8	subjects	subject	NNS
cord-018764-02l423mk	89	9	[	[	-LRB-
cord-018764-02l423mk	89	10	45	45	CD
cord-018764-02l423mk	89	11	]	]	-RRB-
cord-018764-02l423mk	89	12	.	.	.
cord-018764-02l423mk	90	1	Thus	thus	RB
cord-018764-02l423mk	90	2	,	,	,
cord-018764-02l423mk	90	3	it	-PRON-	PRP
cord-018764-02l423mk	90	4	is	be	VBZ
cord-018764-02l423mk	90	5	not	not	RB
cord-018764-02l423mk	90	6	surprising	surprising	JJ
cord-018764-02l423mk	90	7	that	that	IN
cord-018764-02l423mk	90	8	anti	anti	JJ
cord-018764-02l423mk	90	9	-	-	JJ
cord-018764-02l423mk	90	10	TNF	TNF	NNP
cord-018764-02l423mk	90	11	antibody	antibody	NN
cord-018764-02l423mk	90	12	,	,	,
cord-018764-02l423mk	90	13	by	by	IN
cord-018764-02l423mk	90	14	removing	remove	VBG
cord-018764-02l423mk	90	15	inhibitory	inhibitory	JJ
cord-018764-02l423mk	90	16	pressure	pressure	NN
cord-018764-02l423mk	90	17	from	from	IN
cord-018764-02l423mk	90	18	the	the	DT
cord-018764-02l423mk	90	19	pathogen	pathogen	NN
cord-018764-02l423mk	90	20	,	,	,
cord-018764-02l423mk	90	21	can	can	MD
cord-018764-02l423mk	90	22	enhance	enhance	VB
cord-018764-02l423mk	90	23	the	the	DT
cord-018764-02l423mk	90	24	disease	disease	NN
cord-018764-02l423mk	90	25	in	in	IN
cord-018764-02l423mk	90	26	falciparum	falciparum	NN
cord-018764-02l423mk	90	27	malaria	malaria	NN
cord-018764-02l423mk	90	28	[	[	-LRB-
cord-018764-02l423mk	90	29	46	46	CD
cord-018764-02l423mk	90	30	]	]	-RRB-
cord-018764-02l423mk	90	31	,	,	,
cord-018764-02l423mk	90	32	as	as	IN
cord-018764-02l423mk	90	33	shown	show	VBN
cord-018764-02l423mk	90	34	5	5	CD
cord-018764-02l423mk	90	35	years	year	NNS
cord-018764-02l423mk	90	36	earlier	early	RBR
cord-018764-02l423mk	90	37	in	in	IN
cord-018764-02l423mk	90	38	human	human	JJ
cord-018764-02l423mk	90	39	sepsis	sepsis	NN
cord-018764-02l423mk	90	40	[	[	-LRB-
cord-018764-02l423mk	90	41	47	47	CD
cord-018764-02l423mk	90	42	]	]	-RRB-
cord-018764-02l423mk	90	43	.	.	.
cord-018764-02l423mk	91	1	Cytokines	cytokine	NNS
cord-018764-02l423mk	91	2	as	as	IN
cord-018764-02l423mk	91	3	a	a	DT
cord-018764-02l423mk	91	4	disease	disease	NN
cord-018764-02l423mk	91	5	mechanism	mechanism	NN
cord-018764-02l423mk	91	6	extends	extend	VBZ
cord-018764-02l423mk	91	7	beyond	beyond	IN
cord-018764-02l423mk	91	8	malaria	malaria	NN
cord-018764-02l423mk	92	1	As	as	IN
cord-018764-02l423mk	92	2	noted	note	VBN
cord-018764-02l423mk	92	3	above	above	RB
cord-018764-02l423mk	92	4	,	,	,
cord-018764-02l423mk	92	5	the	the	DT
cord-018764-02l423mk	92	6	idea	idea	NN
cord-018764-02l423mk	92	7	that	that	IN
cord-018764-02l423mk	92	8	excessive	excessive	JJ
cord-018764-02l423mk	92	9	production	production	NN
cord-018764-02l423mk	92	10	of	of	IN
cord-018764-02l423mk	92	11	inflammatory	inflammatory	JJ
cord-018764-02l423mk	92	12	cytokines	cytokine	NNS
cord-018764-02l423mk	92	13	underlies	underlie	VBZ
cord-018764-02l423mk	92	14	the	the	DT
cord-018764-02l423mk	92	15	pathology	pathology	NN
cord-018764-02l423mk	92	16	of	of	IN
cord-018764-02l423mk	92	17	illness	illness	NN
cord-018764-02l423mk	92	18	is	be	VBZ
cord-018764-02l423mk	92	19	used	use	VBN
cord-018764-02l423mk	92	20	widely	widely	RB
cord-018764-02l423mk	92	21	,	,	,
cord-018764-02l423mk	92	22	from	from	IN
cord-018764-02l423mk	92	23	malaria	malaria	NN
cord-018764-02l423mk	92	24	across	across	IN
cord-018764-02l423mk	92	25	a	a	DT
cord-018764-02l423mk	92	26	range	range	NN
cord-018764-02l423mk	92	27	of	of	IN
cord-018764-02l423mk	92	28	conditions	condition	NNS
cord-018764-02l423mk	92	29	,	,	,
cord-018764-02l423mk	92	30	infectious	infectious	JJ
cord-018764-02l423mk	92	31	or	or	CC
cord-018764-02l423mk	92	32	otherwise	otherwise	RB
cord-018764-02l423mk	92	33	.	.	.
cord-018764-02l423mk	93	1	As	as	IN
cord-018764-02l423mk	93	2	reviewed	review	VBN
cord-018764-02l423mk	93	3	recently	recently	RB
cord-018764-02l423mk	93	4	[	[	-LRB-
cord-018764-02l423mk	93	5	48	48	CD
cord-018764-02l423mk	93	6	]	]	-RRB-
cord-018764-02l423mk	93	7	,	,	,
cord-018764-02l423mk	93	8	this	this	DT
cord-018764-02l423mk	93	9	now	now	RB
cord-018764-02l423mk	93	10	includes	include	VBZ
cord-018764-02l423mk	93	11	the	the	DT
cord-018764-02l423mk	93	12	illnesses	illness	NNS
cord-018764-02l423mk	93	13	caused	cause	VBN
cord-018764-02l423mk	93	14	by	by	IN
cord-018764-02l423mk	93	15	rickettsias	rickettsias	NNP
cord-018764-02l423mk	93	16	,	,	,
cord-018764-02l423mk	93	17	protozoa	protozoan	NNS
cord-018764-02l423mk	93	18	other	other	JJ
cord-018764-02l423mk	93	19	than	than	IN
cord-018764-02l423mk	93	20	malaria	malaria	NN
cord-018764-02l423mk	93	21	,	,	,
cord-018764-02l423mk	93	22	and	and	CC
cord-018764-02l423mk	93	23	viruses	virus	NNS
cord-018764-02l423mk	93	24	.	.	.
cord-018764-02l423mk	94	1	Increased	increase	VBN
cord-018764-02l423mk	94	2	circulating	circulate	VBG
cord-018764-02l423mk	94	3	levels	level	NNS
cord-018764-02l423mk	94	4	of	of	IN
cord-018764-02l423mk	94	5	these	these	DT
cord-018764-02l423mk	94	6	cytokines	cytokine	NNS
cord-018764-02l423mk	94	7	have	have	VBP
cord-018764-02l423mk	94	8	been	be	VBN
cord-018764-02l423mk	94	9	detected	detect	VBN
cord-018764-02l423mk	94	10	in	in	IN
cord-018764-02l423mk	94	11	the	the	DT
cord-018764-02l423mk	94	12	serum	serum	NN
cord-018764-02l423mk	94	13	very	very	RB
cord-018764-02l423mk	94	14	soon	soon	RB
cord-018764-02l423mk	94	15	after	after	IN
cord-018764-02l423mk	94	16	onset	onset	NN
cord-018764-02l423mk	94	17	of	of	IN
cord-018764-02l423mk	94	18	illness	illness	NN
cord-018764-02l423mk	94	19	in	in	IN
cord-018764-02l423mk	94	20	virtually	virtually	RB
cord-018764-02l423mk	94	21	all	all	PDT
cord-018764-02l423mk	94	22	those	those	DT
cord-018764-02l423mk	94	23	infectious	infectious	JJ
cord-018764-02l423mk	94	24	diseases	disease	NNS
cord-018764-02l423mk	94	25	in	in	IN
cord-018764-02l423mk	94	26	which	which	WDT
cord-018764-02l423mk	94	27	they	-PRON-	PRP
cord-018764-02l423mk	94	28	have	have	VBP
cord-018764-02l423mk	94	29	been	be	VBN
cord-018764-02l423mk	94	30	sought	seek	VBN
cord-018764-02l423mk	94	31	.	.	.
cord-018764-02l423mk	95	1	Some	some	DT
cord-018764-02l423mk	95	2	cytokine	cytokine	NN
cord-018764-02l423mk	95	3	increased	increase	VBD
cord-018764-02l423mk	95	4	,	,	,
cord-018764-02l423mk	95	5	and	and	CC
cord-018764-02l423mk	95	6	consequences	consequence	NNS
cord-018764-02l423mk	95	7	are	be	VBP
cord-018764-02l423mk	95	8	shown	show	VBN
cord-018764-02l423mk	95	9	in	in	IN
cord-018764-02l423mk	95	10	Table	Table	NNP
cord-018764-02l423mk	95	11	2	2	CD
cord-018764-02l423mk	95	12	.	.	.
cord-018764-02l423mk	96	1	When	when	WRB
cord-018764-02l423mk	96	2	rTNF	rTNF	NNP
cord-018764-02l423mk	96	3	was	be	VBD
cord-018764-02l423mk	96	4	under	under	IN
cord-018764-02l423mk	96	5	trial	trial	NN
cord-018764-02l423mk	96	6	in	in	IN
cord-018764-02l423mk	96	7	volunteers	volunteer	NNS
cord-018764-02l423mk	96	8	as	as	IN
cord-018764-02l423mk	96	9	an	an	DT
cord-018764-02l423mk	96	10	anti	anti	JJ
cord-018764-02l423mk	96	11	-	-	JJ
cord-018764-02l423mk	96	12	tumour	tumour	JJ
cord-018764-02l423mk	96	13	agent	agent	NN
cord-018764-02l423mk	96	14	[	[	-LRB-
cord-018764-02l423mk	96	15	49	49	CD
cord-018764-02l423mk	96	16	,	,	,
cord-018764-02l423mk	96	17	50	50	CD
cord-018764-02l423mk	96	18	]	]	-RRB-
cord-018764-02l423mk	96	19	nearly	nearly	RB
cord-018764-02l423mk	96	20	20	20	CD
cord-018764-02l423mk	96	21	years	year	NNS
cord-018764-02l423mk	96	22	ago	ago	RB
cord-018764-02l423mk	96	23	,	,	,
cord-018764-02l423mk	96	24	virtually	virtually	RB
cord-018764-02l423mk	96	25	all	all	DT
cord-018764-02l423mk	96	26	of	of	IN
cord-018764-02l423mk	96	27	the	the	DT
cord-018764-02l423mk	96	28	symptoms	symptom	NNS
cord-018764-02l423mk	96	29	and	and	CC
cord-018764-02l423mk	96	30	signs	sign	NNS
cord-018764-02l423mk	96	31	they	-PRON-	PRP
cord-018764-02l423mk	96	32	share	share	VBP
cord-018764-02l423mk	96	33	were	be	VBD
cord-018764-02l423mk	96	34	reproduced	reproduce	VBN
cord-018764-02l423mk	96	35	as	as	IN
cord-018764-02l423mk	96	36	side	side	NN
cord-018764-02l423mk	96	37	effects	effect	NNS
cord-018764-02l423mk	96	38	.	.	.
cord-018764-02l423mk	97	1	This	this	DT
cord-018764-02l423mk	97	2	includes	include	VBZ
cord-018764-02l423mk	97	3	headache	headache	NN
cord-018764-02l423mk	97	4	,	,	,
cord-018764-02l423mk	97	5	fever	fever	NN
cord-018764-02l423mk	97	6	and	and	CC
cord-018764-02l423mk	97	7	rigours	rigour	NNS
cord-018764-02l423mk	97	8	,	,	,
cord-018764-02l423mk	97	9	nausea	nausea	NN
cord-018764-02l423mk	97	10	and	and	CC
cord-018764-02l423mk	97	11	vomiting	vomiting	NN
cord-018764-02l423mk	97	12	,	,	,
cord-018764-02l423mk	97	13	diarrhoea	diarrhoea	NN
cord-018764-02l423mk	97	14	,	,	,
cord-018764-02l423mk	97	15	anorexia	anorexia	NN
cord-018764-02l423mk	97	16	,	,	,
cord-018764-02l423mk	97	17	myalgia	myalgia	NN
cord-018764-02l423mk	97	18	,	,	,
cord-018764-02l423mk	97	19	thrombocytopaenia	thrombocytopaenia	NNP
cord-018764-02l423mk	97	20	,	,	,
cord-018764-02l423mk	97	21	immunosuppression	immunosuppression	NN
cord-018764-02l423mk	97	22	,	,	,
cord-018764-02l423mk	97	23	and	and	CC
cord-018764-02l423mk	97	24	central	central	JJ
cord-018764-02l423mk	97	25	nervous	nervous	JJ
cord-018764-02l423mk	97	26	system	system	NN
cord-018764-02l423mk	97	27	manifestations	manifestation	NNS
cord-018764-02l423mk	97	28	,	,	,
cord-018764-02l423mk	97	29	all	all	DT
cord-018764-02l423mk	97	30	of	of	IN
cord-018764-02l423mk	97	31	which	which	WDT
cord-018764-02l423mk	97	32	have	have	VBP
cord-018764-02l423mk	97	33	been	be	VBN
cord-018764-02l423mk	97	34	shown	show	VBN
cord-018764-02l423mk	97	35	to	to	TO
cord-018764-02l423mk	97	36	be	be	VB
cord-018764-02l423mk	97	37	caused	cause	VBN
cord-018764-02l423mk	97	38	by	by	IN
cord-018764-02l423mk	97	39	a	a	DT
cord-018764-02l423mk	97	40	mechanism	mechanism	NN
cord-018764-02l423mk	97	41	involving	involve	VBG
cord-018764-02l423mk	97	42	inflammatory	inflammatory	JJ
cord-018764-02l423mk	97	43	cytokines	cytokine	NNS
cord-018764-02l423mk	97	44	.	.	.
cord-018764-02l423mk	98	1	The	the	DT
cord-018764-02l423mk	98	2	rate	rate	NN
cord-018764-02l423mk	98	3	,	,	,
cord-018764-02l423mk	98	4	timing	timing	NN
cord-018764-02l423mk	98	5	and	and	CC
cord-018764-02l423mk	98	6	intensity	intensity	NN
cord-018764-02l423mk	98	7	of	of	IN
cord-018764-02l423mk	98	8	cytokine	cytokine	NN
cord-018764-02l423mk	98	9	release	release	NN
cord-018764-02l423mk	98	10	vary	vary	VBP
cord-018764-02l423mk	98	11	in	in	IN
cord-018764-02l423mk	98	12	different	different	JJ
cord-018764-02l423mk	98	13	disease	disease	NN
cord-018764-02l423mk	98	14	states	state	NNS
cord-018764-02l423mk	98	15	,	,	,
cord-018764-02l423mk	98	16	and	and	CC
cord-018764-02l423mk	98	17	provide	provide	VB
cord-018764-02l423mk	98	18	them	-PRON-	PRP
cord-018764-02l423mk	98	19	with	with	IN
cord-018764-02l423mk	98	20	somewhat	somewhat	RB
cord-018764-02l423mk	98	21	individual	individual	JJ
cord-018764-02l423mk	98	22	clinical	clinical	JJ
cord-018764-02l423mk	98	23	pictures	picture	NNS
cord-018764-02l423mk	98	24	,	,	,
cord-018764-02l423mk	98	25	but	but	CC
cord-018764-02l423mk	98	26	the	the	DT
cord-018764-02l423mk	98	27	fundamentals	fundamental	NNS
cord-018764-02l423mk	98	28	remain	remain	VBP
cord-018764-02l423mk	98	29	.	.	.
cord-018764-02l423mk	99	1	Nevertheless	nevertheless	RB
cord-018764-02l423mk	99	2	,	,	,
cord-018764-02l423mk	99	3	the	the	DT
cord-018764-02l423mk	99	4	clinical	clinical	JJ
cord-018764-02l423mk	99	5	patterns	pattern	NNS
cord-018764-02l423mk	99	6	generated	generate	VBN
cord-018764-02l423mk	99	7	are	be	VBP
cord-018764-02l423mk	99	8	remarkably	remarkably	RB
cord-018764-02l423mk	99	9	close	close	JJ
cord-018764-02l423mk	99	10	,	,	,
cord-018764-02l423mk	99	11	in	in	IN
cord-018764-02l423mk	99	12	that	that	DT
cord-018764-02l423mk	99	13	,	,	,
cord-018764-02l423mk	99	14	at	at	IN
cord-018764-02l423mk	99	15	least	least	JJS
cord-018764-02l423mk	99	16	in	in	IN
cord-018764-02l423mk	99	17	some	some	DT
cord-018764-02l423mk	99	18	populations	population	NNS
cord-018764-02l423mk	99	19	,	,	,
cord-018764-02l423mk	99	20	clinical	clinical	JJ
cord-018764-02l423mk	99	21	features	feature	NNS
cord-018764-02l423mk	99	22	can	can	MD
cord-018764-02l423mk	99	23	not	not	RB
cord-018764-02l423mk	99	24	predict	predict	VB
cord-018764-02l423mk	99	25	a	a	DT
cord-018764-02l423mk	99	26	diagnosis	diagnosis	NN
cord-018764-02l423mk	99	27	of	of	IN
cord-018764-02l423mk	99	28	malaria	malaria	NN
cord-018764-02l423mk	99	29	from	from	IN
cord-018764-02l423mk	99	30	other	other	JJ
cord-018764-02l423mk	99	31	causes	cause	NNS
cord-018764-02l423mk	99	32	of	of	IN
cord-018764-02l423mk	99	33	fever	fever	NN
cord-018764-02l423mk	99	34	[	[	-LRB-
cord-018764-02l423mk	99	35	51	51	CD
cord-018764-02l423mk	99	36	]	]	-RRB-
cord-018764-02l423mk	99	37	.	.	.
cord-018764-02l423mk	100	1	Mature	mature	JJ
cord-018764-02l423mk	100	2	erythrocytic	erythrocytic	JJ
cord-018764-02l423mk	100	3	forms	form	NNS
cord-018764-02l423mk	100	4	of	of	IN
cord-018764-02l423mk	100	5	P.	P.	NNP
cord-018764-02l423mk	100	6	falciparum	falciparum	NNS
cord-018764-02l423mk	100	7	are	be	VBP
cord-018764-02l423mk	100	8	not	not	RB
cord-018764-02l423mk	100	9	seen	see	VBN
cord-018764-02l423mk	100	10	in	in	IN
cord-018764-02l423mk	100	11	peripheral	peripheral	JJ
cord-018764-02l423mk	100	12	blood	blood	NN
cord-018764-02l423mk	100	13	smears	smear	NNS
cord-018764-02l423mk	100	14	,	,	,
cord-018764-02l423mk	100	15	and	and	CC
cord-018764-02l423mk	100	16	cause	cause	VB
cord-018764-02l423mk	100	17	the	the	DT
cord-018764-02l423mk	100	18	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	100	19	they	-PRON-	PRP
cord-018764-02l423mk	100	20	inhabit	inhabit	VBP
cord-018764-02l423mk	100	21	to	to	TO
cord-018764-02l423mk	100	22	adhere	adhere	VB
cord-018764-02l423mk	100	23	to	to	IN
cord-018764-02l423mk	100	24	the	the	DT
cord-018764-02l423mk	100	25	walls	wall	NNS
cord-018764-02l423mk	100	26	of	of	IN
cord-018764-02l423mk	100	27	venules	venule	NNS
cord-018764-02l423mk	100	28	and	and	CC
cord-018764-02l423mk	100	29	capillaries	capillary	NNS
cord-018764-02l423mk	100	30	.	.	.
cord-018764-02l423mk	101	1	From	from	IN
cord-018764-02l423mk	101	2	this	this	DT
cord-018764-02l423mk	101	3	observation	observation	NN
cord-018764-02l423mk	101	4	arose	arise	VBD
cord-018764-02l423mk	101	5	the	the	DT
cord-018764-02l423mk	101	6	widely	widely	RB
cord-018764-02l423mk	101	7	held	held	JJ
cord-018764-02l423mk	101	8	view	view	NN
cord-018764-02l423mk	101	9	that	that	IN
cord-018764-02l423mk	101	10	much	much	JJ
cord-018764-02l423mk	101	11	of	of	IN
cord-018764-02l423mk	101	12	the	the	DT
cord-018764-02l423mk	101	13	pathology	pathology	NN
cord-018764-02l423mk	101	14	following	follow	VBG
cord-018764-02l423mk	101	15	malarial	malarial	JJ
cord-018764-02l423mk	101	16	infection	infection	NN
cord-018764-02l423mk	101	17	is	be	VBZ
cord-018764-02l423mk	101	18	explained	explain	VBN
cord-018764-02l423mk	101	19	through	through	IN
cord-018764-02l423mk	101	20	parasite	parasite	NN
cord-018764-02l423mk	101	21	sequestration	sequestration	NN
cord-018764-02l423mk	101	22	causing	cause	VBG
cord-018764-02l423mk	101	23	impairment	impairment	NN
cord-018764-02l423mk	101	24	of	of	IN
cord-018764-02l423mk	101	25	microvascular	microvascular	JJ
cord-018764-02l423mk	101	26	flow	flow	NN
cord-018764-02l423mk	101	27	.	.	.
cord-018764-02l423mk	102	1	Sequestration	sequestration	NN
cord-018764-02l423mk	102	2	certainly	certainly	RB
cord-018764-02l423mk	102	3	occurs	occur	VBZ
cord-018764-02l423mk	102	4	,	,	,
cord-018764-02l423mk	102	5	since	since	IN
cord-018764-02l423mk	102	6	the	the	DT
cord-018764-02l423mk	102	7	life	life	NN
cord-018764-02l423mk	102	8	cycle	cycle	NN
cord-018764-02l423mk	102	9	dictates	dictate	VBZ
cord-018764-02l423mk	102	10	this	this	DT
cord-018764-02l423mk	102	11	.	.	.
cord-018764-02l423mk	103	1	However	however	RB
cord-018764-02l423mk	103	2	,	,	,
cord-018764-02l423mk	103	3	whether	whether	IN
cord-018764-02l423mk	103	4	the	the	DT
cord-018764-02l423mk	103	5	temporal	temporal	JJ
cord-018764-02l423mk	103	6	and	and	CC
cord-018764-02l423mk	103	7	anatomical	anatomical	JJ
cord-018764-02l423mk	103	8	patterns	pattern	NNS
cord-018764-02l423mk	103	9	of	of	IN
cord-018764-02l423mk	103	10	sequestration	sequestration	NN
cord-018764-02l423mk	103	11	are	be	VBP
cord-018764-02l423mk	103	12	the	the	DT
cord-018764-02l423mk	103	13	same	same	JJ
cord-018764-02l423mk	103	14	in	in	IN
cord-018764-02l423mk	103	15	both	both	DT
cord-018764-02l423mk	103	16	individuals	individual	NNS
cord-018764-02l423mk	103	17	with	with	IN
cord-018764-02l423mk	103	18	fatal	fatal	JJ
cord-018764-02l423mk	103	19	disease	disease	NN
cord-018764-02l423mk	103	20	and	and	CC
cord-018764-02l423mk	103	21	in	in	IN
cord-018764-02l423mk	103	22	parasite	parasite	JJ
cord-018764-02l423mk	103	23	tolerant	tolerant	JJ
cord-018764-02l423mk	103	24	individuals	individual	NNS
cord-018764-02l423mk	103	25	has	have	VBZ
cord-018764-02l423mk	103	26	not	not	RB
cord-018764-02l423mk	103	27	been	be	VBN
cord-018764-02l423mk	103	28	ascertained	ascertain	VBN
cord-018764-02l423mk	103	29	.	.	.
cord-018764-02l423mk	104	1	Consequently	consequently	RB
cord-018764-02l423mk	104	2	,	,	,
cord-018764-02l423mk	104	3	whether	whether	IN
cord-018764-02l423mk	104	4	sequestration	sequestration	NN
cord-018764-02l423mk	104	5	is	be	VBZ
cord-018764-02l423mk	104	6	the	the	DT
cord-018764-02l423mk	104	7	principal	principal	JJ
cord-018764-02l423mk	104	8	instigator	instigator	NN
cord-018764-02l423mk	104	9	of	of	IN
cord-018764-02l423mk	104	10	local	local	JJ
cord-018764-02l423mk	104	11	pathology	pathology	NN
cord-018764-02l423mk	104	12	,	,	,
cord-018764-02l423mk	104	13	or	or	CC
cord-018764-02l423mk	104	14	whether	whether	IN
cord-018764-02l423mk	104	15	sequestration	sequestration	NN
cord-018764-02l423mk	104	16	is	be	VBZ
cord-018764-02l423mk	104	17	an	an	DT
cord-018764-02l423mk	104	18	associated	associate	VBN
cord-018764-02l423mk	104	19	feature	feature	NN
cord-018764-02l423mk	104	20	of	of	IN
cord-018764-02l423mk	104	21	all	all	DT
cord-018764-02l423mk	104	22	malarial	malarial	JJ
cord-018764-02l423mk	104	23	infections	infection	NNS
cord-018764-02l423mk	104	24	with	with	IN
cord-018764-02l423mk	104	25	local	local	JJ
cord-018764-02l423mk	104	26	pathology	pathology	NN
cord-018764-02l423mk	104	27	determined	determine	VBN
cord-018764-02l423mk	104	28	by	by	IN
cord-018764-02l423mk	104	29	other	other	JJ
cord-018764-02l423mk	104	30	factors	factor	NNS
cord-018764-02l423mk	104	31	in	in	IN
cord-018764-02l423mk	104	32	the	the	DT
cord-018764-02l423mk	104	33	host	host	NN
cord-018764-02l423mk	104	34	response	response	NN
cord-018764-02l423mk	104	35	to	to	IN
cord-018764-02l423mk	104	36	the	the	DT
cord-018764-02l423mk	104	37	infection	infection	NN
cord-018764-02l423mk	104	38	,	,	,
cord-018764-02l423mk	104	39	e.g.	e.g.	RB
cord-018764-02l423mk	104	40	a	a	DT
cord-018764-02l423mk	104	41	local	local	JJ
cord-018764-02l423mk	104	42	imbalance	imbalance	NN
cord-018764-02l423mk	104	43	of	of	IN
cord-018764-02l423mk	104	44	inflammatory	inflammatory	JJ
cord-018764-02l423mk	104	45	mediators	mediator	NNS
cord-018764-02l423mk	104	46	,	,	,
cord-018764-02l423mk	104	47	has	have	VBZ
cord-018764-02l423mk	104	48	not	not	RB
cord-018764-02l423mk	104	49	been	be	VBN
cord-018764-02l423mk	104	50	fully	fully	RB
cord-018764-02l423mk	104	51	elucidated	elucidate	VBN
cord-018764-02l423mk	104	52	.	.	.
cord-018764-02l423mk	105	1	Erythrocyte	Erythrocyte	NNP
cord-018764-02l423mk	105	2	cyto	cyto	NN
cord-018764-02l423mk	105	3	-	-	NN
cord-018764-02l423mk	105	4	adherence	adherence	NN
cord-018764-02l423mk	105	5	(	(	-LRB-
cord-018764-02l423mk	105	6	irrespective	irrespective	RB
cord-018764-02l423mk	105	7	of	of	IN
cord-018764-02l423mk	105	8	whether	whether	IN
cord-018764-02l423mk	105	9	this	this	DT
cord-018764-02l423mk	105	10	adhesive	adhesive	NN
cord-018764-02l423mk	105	11	process	process	NN
cord-018764-02l423mk	105	12	is	be	VBZ
cord-018764-02l423mk	105	13	directly	directly	RB
cord-018764-02l423mk	105	14	or	or	CC
cord-018764-02l423mk	105	15	indirectly	indirectly	RB
cord-018764-02l423mk	105	16	due	due	JJ
cord-018764-02l423mk	105	17	to	to	IN
cord-018764-02l423mk	105	18	parasite	parasite	NN
cord-018764-02l423mk	105	19	sequestration	sequestration	NN
cord-018764-02l423mk	105	20	)	)	-RRB-
cord-018764-02l423mk	105	21	has	have	VBZ
cord-018764-02l423mk	105	22	repeatedly	repeatedly	RB
cord-018764-02l423mk	105	23	been	be	VBN
cord-018764-02l423mk	105	24	shown	show	VBN
cord-018764-02l423mk	105	25	to	to	TO
cord-018764-02l423mk	105	26	be	be	VB
cord-018764-02l423mk	105	27	mediated	mediate	VBN
cord-018764-02l423mk	105	28	through	through	IN
cord-018764-02l423mk	105	29	a	a	DT
cord-018764-02l423mk	105	30	series	series	NN
cord-018764-02l423mk	105	31	of	of	IN
cord-018764-02l423mk	105	32	host	host	NN
cord-018764-02l423mk	105	33	-	-	HYPH
cord-018764-02l423mk	105	34	derived	derive	VBN
cord-018764-02l423mk	105	35	ligands	ligand	NNS
cord-018764-02l423mk	105	36	.	.	.
cord-018764-02l423mk	106	1	CD36	CD36	NNP
cord-018764-02l423mk	106	2	and	and	CC
cord-018764-02l423mk	106	3	thrombospondin	thrombospondin	NNP
cord-018764-02l423mk	106	4	were	be	VBD
cord-018764-02l423mk	106	5	the	the	DT
cord-018764-02l423mk	106	6	first	first	JJ
cord-018764-02l423mk	106	7	described	describe	VBN
cord-018764-02l423mk	106	8	endothelial	endothelial	JJ
cord-018764-02l423mk	106	9	receptors	receptor	NNS
cord-018764-02l423mk	106	10	that	that	WDT
cord-018764-02l423mk	106	11	bound	bind	VBD
cord-018764-02l423mk	106	12	infected	infect	VBN
cord-018764-02l423mk	106	13	red	red	JJ
cord-018764-02l423mk	106	14	blood	blood	NN
cord-018764-02l423mk	106	15	cells	cell	NNS
cord-018764-02l423mk	106	16	(	(	-LRB-
cord-018764-02l423mk	106	17	RBCs	rbc	NNS
cord-018764-02l423mk	106	18	)	)	-RRB-
cord-018764-02l423mk	106	19	[	[	-LRB-
cord-018764-02l423mk	106	20	52	52	CD
cord-018764-02l423mk	106	21	,	,	,
cord-018764-02l423mk	106	22	53	53	CD
cord-018764-02l423mk	106	23	]	]	-RRB-
cord-018764-02l423mk	106	24	,	,	,
cord-018764-02l423mk	106	25	with	with	IN
cord-018764-02l423mk	106	26	most	most	RBS
cord-018764-02l423mk	106	27	studied	study	VBN
cord-018764-02l423mk	106	28	wild	wild	JJ
cord-018764-02l423mk	106	29	parasite	parasite	NN
cord-018764-02l423mk	106	30	isolates	isolate	NNS
cord-018764-02l423mk	106	31	demonstrating	demonstrate	VBG
cord-018764-02l423mk	106	32	adhesion	adhesion	NN
cord-018764-02l423mk	106	33	to	to	IN
cord-018764-02l423mk	106	34	CD36	CD36	NNP
cord-018764-02l423mk	106	35	[	[	-LRB-
cord-018764-02l423mk	106	36	54	54	CD
cord-018764-02l423mk	106	37	]	]	-RRB-
cord-018764-02l423mk	106	38	.	.	.
cord-018764-02l423mk	107	1	More	more	RBR
cord-018764-02l423mk	107	2	recently	recently	RB
cord-018764-02l423mk	107	3	,	,	,
cord-018764-02l423mk	107	4	it	-PRON-	PRP
cord-018764-02l423mk	107	5	has	have	VBZ
cord-018764-02l423mk	107	6	been	be	VBN
cord-018764-02l423mk	107	7	shown	show	VBN
cord-018764-02l423mk	107	8	that	that	IN
cord-018764-02l423mk	107	9	P.	P.	NNP
cord-018764-02l423mk	107	10	falciparum	falciparum	NN
cord-018764-02l423mk	107	11	also	also	RB
cord-018764-02l423mk	107	12	interacts	interact	VBZ
cord-018764-02l423mk	107	13	with	with	IN
cord-018764-02l423mk	107	14	other	other	JJ
cord-018764-02l423mk	107	15	host	host	NN
cord-018764-02l423mk	107	16	adhesion	adhesion	NN
cord-018764-02l423mk	107	17	receptors	receptor	NNS
cord-018764-02l423mk	107	18	,	,	,
cord-018764-02l423mk	107	19	i.e.	i.e.	FW
cord-018764-02l423mk	107	20	intercellular	intercellular	JJ
cord-018764-02l423mk	107	21	adhesion	adhesion	NN
cord-018764-02l423mk	107	22	molecule-1	molecule-1	NN
cord-018764-02l423mk	108	1	(	(	-LRB-
cord-018764-02l423mk	108	2	ICAM-1	ICAM-1	NNP
cord-018764-02l423mk	108	3	CD54	CD54	NNP
cord-018764-02l423mk	108	4	)	)	-RRB-
cord-018764-02l423mk	108	5	,	,	,
cord-018764-02l423mk	108	6	vascular	vascular	JJ
cord-018764-02l423mk	108	7	cell	cell	NN
cord-018764-02l423mk	108	8	adhesion	adhesion	NN
cord-018764-02l423mk	108	9	molecule-1	molecule-1	NNP
cord-018764-02l423mk	109	1	(	(	-LRB-
cord-018764-02l423mk	109	2	VCAM-1	VCAM-1	NNP
cord-018764-02l423mk	109	3	CD106	CD106	NNP
cord-018764-02l423mk	109	4	)	)	-RRB-
cord-018764-02l423mk	109	5	and	and	CC
cord-018764-02l423mk	109	6	E	E	NNS
cord-018764-02l423mk	109	7	-	-	NN
cord-018764-02l423mk	109	8	selectin	selectin	JJ
cord-018764-02l423mk	109	9	[	[	-LRB-
cord-018764-02l423mk	109	10	55	55	CD
cord-018764-02l423mk	109	11	,	,	,
cord-018764-02l423mk	109	12	56	56	CD
cord-018764-02l423mk	109	13	]	]	-RRB-
cord-018764-02l423mk	109	14	.	.	.
cord-018764-02l423mk	110	1	Certain	certain	JJ
cord-018764-02l423mk	110	2	adhesive	adhesive	JJ
cord-018764-02l423mk	110	3	phenotypes	phenotype	NNS
cord-018764-02l423mk	110	4	,	,	,
cord-018764-02l423mk	110	5	such	such	JJ
cord-018764-02l423mk	110	6	as	as	IN
cord-018764-02l423mk	110	7	rosetting	rosette	VBG
cord-018764-02l423mk	110	8	(	(	-LRB-
cord-018764-02l423mk	110	9	the	the	DT
cord-018764-02l423mk	110	10	spontaneous	spontaneous	JJ
cord-018764-02l423mk	110	11	tethering	tethering	NN
cord-018764-02l423mk	110	12	of	of	IN
cord-018764-02l423mk	110	13	infected	infected	JJ
cord-018764-02l423mk	110	14	and	and	CC
cord-018764-02l423mk	110	15	non	non	JJ
cord-018764-02l423mk	110	16	-	-	JJ
cord-018764-02l423mk	110	17	infected	infected	JJ
cord-018764-02l423mk	110	18	RBCs	rbc	NNS
cord-018764-02l423mk	110	19	)	)	-RRB-
cord-018764-02l423mk	110	20	and	and	CC
cord-018764-02l423mk	110	21	clumping	clumping	NN
cord-018764-02l423mk	110	22	(	(	-LRB-
cord-018764-02l423mk	110	23	tethering	tethering	NN
cord-018764-02l423mk	110	24	of	of	IN
cord-018764-02l423mk	110	25	infected	infected	JJ
cord-018764-02l423mk	110	26	RBCs	rbc	NNS
cord-018764-02l423mk	110	27	through	through	IN
cord-018764-02l423mk	110	28	platelets	platelet	NNS
cord-018764-02l423mk	110	29	)	)	-RRB-
cord-018764-02l423mk	110	30	have	have	VBP
cord-018764-02l423mk	110	31	been	be	VBN
cord-018764-02l423mk	110	32	preferentially	preferentially	RB
cord-018764-02l423mk	110	33	associated	associate	VBN
cord-018764-02l423mk	110	34	with	with	IN
cord-018764-02l423mk	110	35	severe	severe	JJ
cord-018764-02l423mk	110	36	malarial	malarial	JJ
cord-018764-02l423mk	110	37	disease	disease	NN
cord-018764-02l423mk	110	38	[	[	-LRB-
cord-018764-02l423mk	110	39	57	57	CD
cord-018764-02l423mk	110	40	,	,	,
cord-018764-02l423mk	110	41	58	58	CD
cord-018764-02l423mk	110	42	]	]	-RRB-
cord-018764-02l423mk	110	43	.	.	.
cord-018764-02l423mk	111	1	CD36	CD36	NNP
cord-018764-02l423mk	111	2	is	be	VBZ
cord-018764-02l423mk	111	3	involved	involve	VBN
cord-018764-02l423mk	111	4	in	in	IN
cord-018764-02l423mk	111	5	both	both	DT
cord-018764-02l423mk	111	6	mechanisms	mechanism	NNS
cord-018764-02l423mk	111	7	of	of	IN
cord-018764-02l423mk	111	8	adhesion	adhesion	NN
cord-018764-02l423mk	111	9	,	,	,
cord-018764-02l423mk	111	10	and	and	CC
cord-018764-02l423mk	111	11	a	a	DT
cord-018764-02l423mk	111	12	non	non	JJ
cord-018764-02l423mk	111	13	-	-	JJ
cord-018764-02l423mk	111	14	sense	sense	JJ
cord-018764-02l423mk	111	15	mutation	mutation	NN
cord-018764-02l423mk	111	16	in	in	IN
cord-018764-02l423mk	111	17	the	the	DT
cord-018764-02l423mk	111	18	gene	gene	NN
cord-018764-02l423mk	111	19	encoding	encoding	NN
cord-018764-02l423mk	111	20	for	for	IN
cord-018764-02l423mk	111	21	CD36	CD36	NNP
cord-018764-02l423mk	111	22	has	have	VBZ
cord-018764-02l423mk	111	23	also	also	RB
cord-018764-02l423mk	111	24	been	be	VBN
cord-018764-02l423mk	111	25	associated	associate	VBN
cord-018764-02l423mk	111	26	with	with	IN
cord-018764-02l423mk	111	27	protection	protection	NN
cord-018764-02l423mk	111	28	from	from	IN
cord-018764-02l423mk	111	29	severe	severe	JJ
cord-018764-02l423mk	111	30	malaria	malaria	NN
cord-018764-02l423mk	111	31	[	[	-LRB-
cord-018764-02l423mk	111	32	59	59	CD
cord-018764-02l423mk	111	33	]	]	-RRB-
cord-018764-02l423mk	111	34	.	.	.
cord-018764-02l423mk	112	1	Polymorphisms	polymorphism	NNS
cord-018764-02l423mk	112	2	in	in	IN
cord-018764-02l423mk	112	3	the	the	DT
cord-018764-02l423mk	112	4	gene	gene	NN
cord-018764-02l423mk	112	5	encoding	encode	VBG
cord-018764-02l423mk	112	6	ICAM-1	ICAM-1	NNP
cord-018764-02l423mk	112	7	have	have	VBP
cord-018764-02l423mk	112	8	also	also	RB
cord-018764-02l423mk	112	9	been	be	VBN
cord-018764-02l423mk	112	10	associated	associate	VBN
cord-018764-02l423mk	112	11	with	with	IN
cord-018764-02l423mk	112	12	susceptibility	susceptibility	NN
cord-018764-02l423mk	112	13	to	to	IN
cord-018764-02l423mk	112	14	severe	severe	JJ
cord-018764-02l423mk	112	15	disease	disease	NN
cord-018764-02l423mk	112	16	[	[	-LRB-
cord-018764-02l423mk	112	17	27	27	CD
cord-018764-02l423mk	112	18	]	]	-RRB-
cord-018764-02l423mk	112	19	.	.	.
cord-018764-02l423mk	113	1	Furthermore	furthermore	RB
cord-018764-02l423mk	113	2	,	,	,
cord-018764-02l423mk	113	3	ICAM-1	icam-1	UH
cord-018764-02l423mk	113	4	,	,	,
cord-018764-02l423mk	113	5	together	together	RB
cord-018764-02l423mk	113	6	with	with	IN
cord-018764-02l423mk	113	7	VCAM	VCAM	NNP
cord-018764-02l423mk	113	8	and	and	CC
cord-018764-02l423mk	113	9	E	E	NNP
cord-018764-02l423mk	113	10	-	-	NN
cord-018764-02l423mk	113	11	selectin	selectin	NNP
cord-018764-02l423mk	113	12	,	,	,
cord-018764-02l423mk	113	13	are	be	VBP
cord-018764-02l423mk	113	14	up	up	RB
cord-018764-02l423mk	113	15	-	-	HYPH
cord-018764-02l423mk	113	16	regulated	regulate	VBN
cord-018764-02l423mk	113	17	by	by	IN
cord-018764-02l423mk	113	18	TNF	TNF	NNP
cord-018764-02l423mk	113	19	,	,	,
cord-018764-02l423mk	113	20	with	with	IN
cord-018764-02l423mk	113	21	circulating	circulate	VBG
cord-018764-02l423mk	113	22	levels	level	NNS
cord-018764-02l423mk	113	23	of	of	IN
cord-018764-02l423mk	113	24	these	these	DT
cord-018764-02l423mk	113	25	ligands	ligand	NNS
cord-018764-02l423mk	113	26	shown	show	VBN
cord-018764-02l423mk	113	27	to	to	TO
cord-018764-02l423mk	113	28	be	be	VB
cord-018764-02l423mk	113	29	increased	increase	VBN
cord-018764-02l423mk	113	30	in	in	IN
cord-018764-02l423mk	113	31	severe	severe	JJ
cord-018764-02l423mk	113	32	malaria	malaria	NN
cord-018764-02l423mk	113	33	compared	compare	VBN
cord-018764-02l423mk	113	34	to	to	IN
cord-018764-02l423mk	113	35	uncomplicated	uncomplicated	JJ
cord-018764-02l423mk	113	36	infection	infection	NN
cord-018764-02l423mk	113	37	[	[	-LRB-
cord-018764-02l423mk	113	38	60	60	CD
cord-018764-02l423mk	113	39	]	]	-RRB-
cord-018764-02l423mk	113	40	.	.	.
cord-018764-02l423mk	114	1	Sequestration	sequestration	NN
cord-018764-02l423mk	114	2	during	during	IN
cord-018764-02l423mk	114	3	falciparum	falciparum	NN
cord-018764-02l423mk	114	4	malaria	malaria	NN
cord-018764-02l423mk	114	5	appears	appear	VBZ
cord-018764-02l423mk	114	6	to	to	TO
cord-018764-02l423mk	114	7	be	be	VB
cord-018764-02l423mk	114	8	concentrated	concentrate	VBN
cord-018764-02l423mk	114	9	in	in	IN
cord-018764-02l423mk	114	10	the	the	DT
cord-018764-02l423mk	114	11	brain	brain	NN
cord-018764-02l423mk	114	12	and	and	CC
cord-018764-02l423mk	114	13	placenta	placenta	NN
cord-018764-02l423mk	114	14	.	.	.
cord-018764-02l423mk	115	1	There	there	EX
cord-018764-02l423mk	115	2	is	be	VBZ
cord-018764-02l423mk	115	3	some	some	DT
cord-018764-02l423mk	115	4	evidence	evidence	NN
cord-018764-02l423mk	115	5	to	to	TO
cord-018764-02l423mk	115	6	suggest	suggest	VB
cord-018764-02l423mk	115	7	that	that	IN
cord-018764-02l423mk	115	8	the	the	DT
cord-018764-02l423mk	115	9	propensity	propensity	NN
cord-018764-02l423mk	115	10	of	of	IN
cord-018764-02l423mk	115	11	inflammatory	inflammatory	JJ
cord-018764-02l423mk	115	12	cytokines	cytokine	NNS
cord-018764-02l423mk	115	13	to	to	IN
cord-018764-02l423mk	115	14	up	up	RB
cord-018764-02l423mk	115	15	-	-	HYPH
cord-018764-02l423mk	115	16	regulate	regulate	VB
cord-018764-02l423mk	115	17	cell	cell	NN
cord-018764-02l423mk	115	18	adhesion	adhesion	NN
cord-018764-02l423mk	115	19	molecules	molecule	NNS
cord-018764-02l423mk	115	20	,	,	,
cord-018764-02l423mk	115	21	secondary	secondary	JJ
cord-018764-02l423mk	115	22	to	to	IN
cord-018764-02l423mk	115	23	local	local	JJ
cord-018764-02l423mk	115	24	variation	variation	NN
cord-018764-02l423mk	115	25	in	in	IN
cord-018764-02l423mk	115	26	the	the	DT
cord-018764-02l423mk	115	27	density	density	NN
cord-018764-02l423mk	115	28	of	of	IN
cord-018764-02l423mk	115	29	thrombomodulin	thrombomodulin	NNP
cord-018764-02l423mk	115	30	,	,	,
cord-018764-02l423mk	115	31	is	be	VBZ
cord-018764-02l423mk	115	32	potentially	potentially	RB
cord-018764-02l423mk	115	33	higher	high	JJR
cord-018764-02l423mk	115	34	in	in	IN
cord-018764-02l423mk	115	35	the	the	DT
cord-018764-02l423mk	115	36	microvasculature	microvasculature	NN
cord-018764-02l423mk	115	37	of	of	IN
cord-018764-02l423mk	115	38	the	the	DT
cord-018764-02l423mk	115	39	brain	brain	NN
cord-018764-02l423mk	115	40	and	and	CC
cord-018764-02l423mk	115	41	placenta	placenta	NN
cord-018764-02l423mk	115	42	compared	compare	VBN
cord-018764-02l423mk	115	43	to	to	IN
cord-018764-02l423mk	115	44	other	other	JJ
cord-018764-02l423mk	115	45	tissues	tissue	NNS
cord-018764-02l423mk	115	46	.	.	.
cord-018764-02l423mk	116	1	As	as	IN
cord-018764-02l423mk	116	2	reviewed	review	VBN
cord-018764-02l423mk	116	3	[	[	-LRB-
cord-018764-02l423mk	116	4	61	61	CD
cord-018764-02l423mk	116	5	]	]	-RRB-
cord-018764-02l423mk	116	6	,	,	,
cord-018764-02l423mk	116	7	TNF	TNF	NNP
cord-018764-02l423mk	116	8	and	and	CC
cord-018764-02l423mk	116	9	IL-1	IL-1	NNP
cord-018764-02l423mk	116	10	increase	increase	VBP
cord-018764-02l423mk	116	11	tissue	tissue	NN
cord-018764-02l423mk	116	12	factor	factor	NN
cord-018764-02l423mk	116	13	expression	expression	NN
cord-018764-02l423mk	116	14	on	on	IN
cord-018764-02l423mk	116	15	endothelial	endothelial	JJ
cord-018764-02l423mk	116	16	cells	cell	NNS
cord-018764-02l423mk	116	17	,	,	,
cord-018764-02l423mk	116	18	thereby	thereby	RB
cord-018764-02l423mk	116	19	initiating	initiate	VBG
cord-018764-02l423mk	116	20	pathways	pathway	NNS
cord-018764-02l423mk	116	21	that	that	WDT
cord-018764-02l423mk	116	22	generate	generate	VBP
cord-018764-02l423mk	116	23	thrombin	thrombin	JJ
cord-018764-02l423mk	116	24	[	[	-LRB-
cord-018764-02l423mk	116	25	62	62	CD
cord-018764-02l423mk	116	26	]	]	-RRB-
cord-018764-02l423mk	116	27	.	.	.
cord-018764-02l423mk	117	1	When	when	WRB
cord-018764-02l423mk	117	2	thrombin	thrombin	NN
cord-018764-02l423mk	117	3	binds	bind	VBZ
cord-018764-02l423mk	117	4	to	to	IN
cord-018764-02l423mk	117	5	thrombomodulin	thrombomodulin	NNP
cord-018764-02l423mk	117	6	on	on	IN
cord-018764-02l423mk	117	7	the	the	DT
cord-018764-02l423mk	117	8	endothelial	endothelial	JJ
cord-018764-02l423mk	117	9	cell	cell	NN
cord-018764-02l423mk	117	10	surface	surface	NN
cord-018764-02l423mk	117	11	,	,	,
cord-018764-02l423mk	117	12	protein	protein	NN
cord-018764-02l423mk	117	13	C	C	NNP
cord-018764-02l423mk	117	14	is	be	VBZ
cord-018764-02l423mk	117	15	activated	activate	VBN
cord-018764-02l423mk	117	16	,	,	,
cord-018764-02l423mk	117	17	which	which	WDT
cord-018764-02l423mk	117	18	in	in	IN
cord-018764-02l423mk	117	19	turn	turn	NN
cord-018764-02l423mk	117	20	can	can	MD
cord-018764-02l423mk	117	21	lead	lead	VB
cord-018764-02l423mk	117	22	to	to	IN
cord-018764-02l423mk	117	23	further	further	JJ
cord-018764-02l423mk	117	24	downstream	downstream	JJ
cord-018764-02l423mk	117	25	activation	activation	NN
cord-018764-02l423mk	117	26	of	of	IN
cord-018764-02l423mk	117	27	the	the	DT
cord-018764-02l423mk	117	28	coagulation	coagulation	NN
cord-018764-02l423mk	117	29	cascade	cascade	NN
cord-018764-02l423mk	117	30	.	.	.
cord-018764-02l423mk	118	1	Therefore	therefore	RB
cord-018764-02l423mk	118	2	vasculature	vasculature	VBG
cord-018764-02l423mk	118	3	with	with	IN
cord-018764-02l423mk	118	4	lowest	low	JJS
cord-018764-02l423mk	118	5	thrombomodulin	thrombomodulin	NN
cord-018764-02l423mk	118	6	densities	density	NNS
cord-018764-02l423mk	118	7	on	on	IN
cord-018764-02l423mk	118	8	the	the	DT
cord-018764-02l423mk	118	9	endothelial	endothelial	JJ
cord-018764-02l423mk	118	10	cell	cell	NN
cord-018764-02l423mk	118	11	surface	surface	NN
cord-018764-02l423mk	118	12	(	(	-LRB-
cord-018764-02l423mk	118	13	brain	brain	NN
cord-018764-02l423mk	118	14	least	least	JJS
cord-018764-02l423mk	118	15	,	,	,
cord-018764-02l423mk	118	16	placenta	placenta	NN
cord-018764-02l423mk	118	17	next	next	RB
cord-018764-02l423mk	118	18	least	least	JJS
cord-018764-02l423mk	118	19	,	,	,
cord-018764-02l423mk	118	20	and	and	CC
cord-018764-02l423mk	118	21	other	other	JJ
cord-018764-02l423mk	118	22	organs	organ	NNS
cord-018764-02l423mk	118	23	more	more	RBR
cord-018764-02l423mk	118	24	[	[	-LRB-
cord-018764-02l423mk	118	25	63	63	CD
cord-018764-02l423mk	118	26	]	]	-RRB-
cord-018764-02l423mk	118	27	)	)	-RRB-
cord-018764-02l423mk	118	28	will	will	MD
cord-018764-02l423mk	118	29	have	have	VB
cord-018764-02l423mk	118	30	more	more	RBR
cord-018764-02l423mk	118	31	unbound	unbound	JJ
cord-018764-02l423mk	118	32	thrombin	thrombin	NN
cord-018764-02l423mk	118	33	available	available	JJ
cord-018764-02l423mk	118	34	for	for	IN
cord-018764-02l423mk	118	35	its	-PRON-	PRP$
cord-018764-02l423mk	118	36	other	other	JJ
cord-018764-02l423mk	118	37	functions	function	NNS
cord-018764-02l423mk	118	38	on	on	IN
cord-018764-02l423mk	118	39	activated	activate	VBN
cord-018764-02l423mk	118	40	endothelium	endothelium	NN
cord-018764-02l423mk	118	41	.	.	.
cord-018764-02l423mk	119	1	These	these	DT
cord-018764-02l423mk	119	2	other	other	JJ
cord-018764-02l423mk	119	3	functions	function	NNS
cord-018764-02l423mk	119	4	include	include	VBP
cord-018764-02l423mk	119	5	up	up	IN
cord-018764-02l423mk	119	6	-	-	HYPH
cord-018764-02l423mk	119	7	regulation	regulation	NN
cord-018764-02l423mk	119	8	of	of	IN
cord-018764-02l423mk	119	9	adhesion	adhesion	NN
cord-018764-02l423mk	119	10	molecules	molecule	NNS
cord-018764-02l423mk	119	11	such	such	JJ
cord-018764-02l423mk	119	12	as	as	IN
cord-018764-02l423mk	119	13	selectins	selectin	NNS
cord-018764-02l423mk	119	14	,	,	,
cord-018764-02l423mk	119	15	ICAM-1	ICAM-1	NNP
cord-018764-02l423mk	119	16	,	,	,
cord-018764-02l423mk	119	17	VCAM-1	VCAM-1	NNP
cord-018764-02l423mk	119	18	[	[	-LRB-
cord-018764-02l423mk	119	19	64	64	CD
cord-018764-02l423mk	119	20	]	]	-RRB-
cord-018764-02l423mk	119	21	and	and	CC
cord-018764-02l423mk	119	22	monocyte	monocyte	NNP
cord-018764-02l423mk	119	23	chemotactic	chemotactic	VBD
cord-018764-02l423mk	119	24	protein-1	protein-1	NNP
cord-018764-02l423mk	119	25	(	(	-LRB-
cord-018764-02l423mk	119	26	MCP-1	MCP-1	NNP
cord-018764-02l423mk	119	27	)	)	-RRB-
cord-018764-02l423mk	119	28	[	[	-LRB-
cord-018764-02l423mk	119	29	65	65	CD
cord-018764-02l423mk	119	30	]	]	-RRB-
cord-018764-02l423mk	119	31	.	.	.
cord-018764-02l423mk	120	1	Therefore	therefore	RB
cord-018764-02l423mk	120	2	,	,	,
cord-018764-02l423mk	120	3	up	up	IN
cord-018764-02l423mk	120	4	-	-	HYPH
cord-018764-02l423mk	120	5	regulation	regulation	NN
cord-018764-02l423mk	120	6	of	of	IN
cord-018764-02l423mk	120	7	adhesion	adhesion	NN
cord-018764-02l423mk	120	8	molecules	molecule	NNS
cord-018764-02l423mk	120	9	within	within	IN
cord-018764-02l423mk	120	10	the	the	DT
cord-018764-02l423mk	120	11	cerebral	cerebral	JJ
cord-018764-02l423mk	120	12	vessels	vessel	NNS
cord-018764-02l423mk	120	13	may	may	MD
cord-018764-02l423mk	120	14	occur	occur	VB
cord-018764-02l423mk	120	15	as	as	IN
cord-018764-02l423mk	120	16	a	a	DT
cord-018764-02l423mk	120	17	local	local	JJ
cord-018764-02l423mk	120	18	endothelial	endothelial	JJ
cord-018764-02l423mk	120	19	response	response	NN
cord-018764-02l423mk	120	20	to	to	IN
cord-018764-02l423mk	120	21	systemic	systemic	JJ
cord-018764-02l423mk	120	22	inflammation	inflammation	NN
cord-018764-02l423mk	120	23	and	and	CC
cord-018764-02l423mk	120	24	may	may	MD
cord-018764-02l423mk	120	25	not	not	RB
cord-018764-02l423mk	120	26	necessarily	necessarily	RB
cord-018764-02l423mk	120	27	be	be	VB
cord-018764-02l423mk	120	28	precipitated	precipitate	VBN
cord-018764-02l423mk	120	29	by	by	IN
cord-018764-02l423mk	120	30	parasite	parasite	NN
cord-018764-02l423mk	120	31	sequestration	sequestration	NN
cord-018764-02l423mk	120	32	.	.	.
cord-018764-02l423mk	121	1	Anaemia	anaemia	NN
cord-018764-02l423mk	121	2	is	be	VBZ
cord-018764-02l423mk	121	3	another	another	DT
cord-018764-02l423mk	121	4	obvious	obvious	JJ
cord-018764-02l423mk	121	5	way	way	NN
cord-018764-02l423mk	121	6	in	in	IN
cord-018764-02l423mk	121	7	which	which	WDT
cord-018764-02l423mk	121	8	too	too	RB
cord-018764-02l423mk	121	9	little	little	JJ
cord-018764-02l423mk	121	10	oxygen	oxygen	NN
cord-018764-02l423mk	121	11	reaches	reach	VBZ
cord-018764-02l423mk	121	12	cells	cell	NNS
cord-018764-02l423mk	121	13	,	,	,
cord-018764-02l423mk	121	14	and	and	CC
cord-018764-02l423mk	121	15	thus	thus	RB
cord-018764-02l423mk	121	16	their	-PRON-	PRP$
cord-018764-02l423mk	121	17	mitochondria	mitochondrion	NNS
cord-018764-02l423mk	121	18	[	[	-LRB-
cord-018764-02l423mk	121	19	66	66	CD
cord-018764-02l423mk	121	20	]	]	-RRB-
cord-018764-02l423mk	121	21	.	.	.
cord-018764-02l423mk	122	1	As	as	IN
cord-018764-02l423mk	122	2	recently	recently	RB
cord-018764-02l423mk	122	3	reviewed	review	VBN
cord-018764-02l423mk	122	4	[	[	-LRB-
cord-018764-02l423mk	122	5	67	67	CD
cord-018764-02l423mk	122	6	]	]	-RRB-
cord-018764-02l423mk	122	7	,	,	,
cord-018764-02l423mk	122	8	critical	critical	JJ
cord-018764-02l423mk	122	9	illness	illness	NN
cord-018764-02l423mk	122	10	associated	associate	VBN
cord-018764-02l423mk	122	11	with	with	IN
cord-018764-02l423mk	122	12	an	an	DT
cord-018764-02l423mk	122	13	inflammatory	inflammatory	JJ
cord-018764-02l423mk	122	14	response	response	NN
cord-018764-02l423mk	122	15	invariably	invariably	RB
cord-018764-02l423mk	122	16	causes	cause	VBZ
cord-018764-02l423mk	122	17	multifactorial	multifactorial	JJ
cord-018764-02l423mk	122	18	anaemia	anaemia	NN
cord-018764-02l423mk	122	19	.	.	.
cord-018764-02l423mk	123	1	Obviously	obviously	RB
cord-018764-02l423mk	123	2	a	a	DT
cord-018764-02l423mk	123	3	high	high	JJ
cord-018764-02l423mk	123	4	parasite	parasite	NN
cord-018764-02l423mk	123	5	load	load	NN
cord-018764-02l423mk	123	6	in	in	IN
cord-018764-02l423mk	123	7	malaria	malaria	NN
cord-018764-02l423mk	123	8	indicates	indicate	VBZ
cord-018764-02l423mk	123	9	that	that	IN
cord-018764-02l423mk	123	10	the	the	DT
cord-018764-02l423mk	123	11	infected	infected	JJ
cord-018764-02l423mk	123	12	RBCs	rbc	NNS
cord-018764-02l423mk	123	13	will	will	MD
cord-018764-02l423mk	123	14	soon	soon	RB
cord-018764-02l423mk	123	15	burst	burst	VB
cord-018764-02l423mk	123	16	when	when	WRB
cord-018764-02l423mk	123	17	the	the	DT
cord-018764-02l423mk	123	18	next	next	JJ
cord-018764-02l423mk	123	19	generation	generation	NN
cord-018764-02l423mk	123	20	of	of	IN
cord-018764-02l423mk	123	21	erythrocytic	erythrocytic	JJ
cord-018764-02l423mk	123	22	forms	form	NNS
cord-018764-02l423mk	123	23	escapes	escape	VBZ
cord-018764-02l423mk	123	24	,	,	,
cord-018764-02l423mk	123	25	but	but	CC
cord-018764-02l423mk	123	26	anaemia	anaemia	NN
cord-018764-02l423mk	123	27	does	do	VBZ
cord-018764-02l423mk	123	28	not	not	RB
cord-018764-02l423mk	123	29	correlate	correlate	VB
cord-018764-02l423mk	123	30	with	with	IN
cord-018764-02l423mk	123	31	parasitaemia	parasitaemia	NNP
cord-018764-02l423mk	123	32	,	,	,
cord-018764-02l423mk	123	33	and	and	CC
cord-018764-02l423mk	123	34	sometimes	sometimes	RB
cord-018764-02l423mk	123	35	is	be	VBZ
cord-018764-02l423mk	123	36	extreme	extreme	JJ
cord-018764-02l423mk	123	37	when	when	WRB
cord-018764-02l423mk	123	38	very	very	RB
cord-018764-02l423mk	123	39	few	few	JJ
cord-018764-02l423mk	123	40	parasites	parasite	NNS
cord-018764-02l423mk	123	41	are	be	VBP
cord-018764-02l423mk	123	42	,	,	,
cord-018764-02l423mk	123	43	or	or	CC
cord-018764-02l423mk	123	44	have	have	VBP
cord-018764-02l423mk	123	45	been	be	VBN
cord-018764-02l423mk	123	46	,	,	,
cord-018764-02l423mk	123	47	present	present	JJ
cord-018764-02l423mk	123	48	.	.	.
cord-018764-02l423mk	124	1	The	the	DT
cord-018764-02l423mk	124	2	severe	severe	JJ
cord-018764-02l423mk	124	3	anaemia	anaemia	NN
cord-018764-02l423mk	124	4	in	in	IN
cord-018764-02l423mk	124	5	transgenic	transgenic	JJ
cord-018764-02l423mk	124	6	mice	mouse	NNS
cord-018764-02l423mk	124	7	expressing	express	VBG
cord-018764-02l423mk	124	8	human	human	JJ
cord-018764-02l423mk	124	9	TNF	TNF	NNP
cord-018764-02l423mk	124	10	[	[	-LRB-
cord-018764-02l423mk	124	11	68	68	CD
cord-018764-02l423mk	124	12	]	]	-RRB-
cord-018764-02l423mk	124	13	incriminates	incriminate	VBZ
cord-018764-02l423mk	124	14	the	the	DT
cord-018764-02l423mk	124	15	inflammatory	inflammatory	JJ
cord-018764-02l423mk	124	16	response	response	NN
cord-018764-02l423mk	124	17	itself	-PRON-	PRP
cord-018764-02l423mk	124	18	,	,	,
cord-018764-02l423mk	124	19	so	so	RB
cord-018764-02l423mk	124	20	anaemia	anaemia	NN
cord-018764-02l423mk	124	21	and	and	CC
cord-018764-02l423mk	124	22	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	124	23	dysfunction	dysfunction	NN
cord-018764-02l423mk	124	24	(	(	-LRB-
cord-018764-02l423mk	124	25	see	see	VB
cord-018764-02l423mk	124	26	Mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	124	27	dysfunction	dysfunction	NN
cord-018764-02l423mk	124	28	section	section	NN
cord-018764-02l423mk	124	29	below	below	IN
cord-018764-02l423mk	124	30	)	)	-RRB-
cord-018764-02l423mk	124	31	,	,	,
cord-018764-02l423mk	124	32	both	both	DT
cord-018764-02l423mk	124	33	consequences	consequence	NNS
cord-018764-02l423mk	124	34	of	of	IN
cord-018764-02l423mk	124	35	systemic	systemic	JJ
cord-018764-02l423mk	124	36	inflammation	inflammation	NN
cord-018764-02l423mk	124	37	,	,	,
cord-018764-02l423mk	124	38	can	can	MD
cord-018764-02l423mk	124	39	be	be	VB
cord-018764-02l423mk	124	40	expected	expect	VBN
cord-018764-02l423mk	124	41	to	to	TO
cord-018764-02l423mk	124	42	coexist	coexist	VB
cord-018764-02l423mk	124	43	,	,	,
cord-018764-02l423mk	124	44	and	and	CC
cord-018764-02l423mk	124	45	both	both	DT
cord-018764-02l423mk	124	46	contribute	contribute	VBP
cord-018764-02l423mk	124	47	to	to	IN
cord-018764-02l423mk	124	48	total	total	JJ
cord-018764-02l423mk	124	49	energy	energy	NN
cord-018764-02l423mk	124	50	depletion	depletion	NN
cord-018764-02l423mk	124	51	.	.	.
cord-018764-02l423mk	125	1	The	the	DT
cord-018764-02l423mk	125	2	lifespan	lifespan	NN
cord-018764-02l423mk	125	3	of	of	IN
cord-018764-02l423mk	125	4	an	an	DT
cord-018764-02l423mk	125	5	RBC	RBC	NNP
cord-018764-02l423mk	125	6	is	be	VBZ
cord-018764-02l423mk	125	7	,	,	,
cord-018764-02l423mk	125	8	in	in	IN
cord-018764-02l423mk	125	9	part	part	NN
cord-018764-02l423mk	125	10	,	,	,
cord-018764-02l423mk	125	11	limited	limit	VBN
cord-018764-02l423mk	125	12	by	by	IN
cord-018764-02l423mk	125	13	how	how	WRB
cord-018764-02l423mk	125	14	long	long	RB
cord-018764-02l423mk	125	15	it	-PRON-	PRP
cord-018764-02l423mk	125	16	can	can	MD
cord-018764-02l423mk	125	17	remain	remain	VB
cord-018764-02l423mk	125	18	flexible	flexible	JJ
cord-018764-02l423mk	125	19	enough	enough	RB
cord-018764-02l423mk	125	20	to	to	TO
cord-018764-02l423mk	125	21	squeeze	squeeze	VB
cord-018764-02l423mk	125	22	through	through	IN
cord-018764-02l423mk	125	23	fenestrations	fenestration	NNS
cord-018764-02l423mk	125	24	in	in	IN
cord-018764-02l423mk	125	25	specialised	specialised	JJ
cord-018764-02l423mk	125	26	vessels	vessel	NNS
cord-018764-02l423mk	125	27	in	in	IN
cord-018764-02l423mk	125	28	the	the	DT
cord-018764-02l423mk	125	29	red	red	JJ
cord-018764-02l423mk	125	30	pulp	pulp	NN
cord-018764-02l423mk	125	31	of	of	IN
cord-018764-02l423mk	125	32	the	the	DT
cord-018764-02l423mk	125	33	spleen	spleen	NN
cord-018764-02l423mk	125	34	,	,	,
cord-018764-02l423mk	125	35	and	and	CC
cord-018764-02l423mk	125	36	thus	thus	RB
cord-018764-02l423mk	125	37	avoid	avoid	VB
cord-018764-02l423mk	125	38	phagocytosis	phagocytosis	NN
cord-018764-02l423mk	125	39	by	by	IN
cord-018764-02l423mk	125	40	adjacent	adjacent	JJ
cord-018764-02l423mk	125	41	macrophages	macrophage	NNS
cord-018764-02l423mk	125	42	.	.	.
cord-018764-02l423mk	126	1	Normally	normally	RB
cord-018764-02l423mk	126	2	this	this	DT
cord-018764-02l423mk	126	3	loss	loss	NN
cord-018764-02l423mk	126	4	is	be	VBZ
cord-018764-02l423mk	126	5	balanced	balance	VBN
cord-018764-02l423mk	126	6	by	by	IN
cord-018764-02l423mk	126	7	erythropoiesis	erythropoiesis	NN
cord-018764-02l423mk	126	8	,	,	,
cord-018764-02l423mk	126	9	and	and	CC
cord-018764-02l423mk	126	10	haematocrit	haematocrit	NNP
cord-018764-02l423mk	126	11	remains	remain	VBZ
cord-018764-02l423mk	126	12	normal	normal	JJ
cord-018764-02l423mk	126	13	.	.	.
cord-018764-02l423mk	127	1	If	if	IN
cord-018764-02l423mk	127	2	RBCs	rbc	NNS
cord-018764-02l423mk	127	3	develop	develop	VBP
cord-018764-02l423mk	127	4	a	a	DT
cord-018764-02l423mk	127	5	premature	premature	JJ
cord-018764-02l423mk	127	6	loss	loss	NN
cord-018764-02l423mk	127	7	of	of	IN
cord-018764-02l423mk	127	8	deformability	deformability	NN
cord-018764-02l423mk	127	9	they	-PRON-	PRP
cord-018764-02l423mk	127	10	are	be	VBP
cord-018764-02l423mk	127	11	removed	remove	VBN
cord-018764-02l423mk	127	12	from	from	IN
cord-018764-02l423mk	127	13	the	the	DT
cord-018764-02l423mk	127	14	circulation	circulation	NN
cord-018764-02l423mk	127	15	earlier	early	RBR
cord-018764-02l423mk	127	16	.	.	.
cord-018764-02l423mk	128	1	This	this	DT
cord-018764-02l423mk	128	2	loss	loss	NN
cord-018764-02l423mk	128	3	of	of	IN
cord-018764-02l423mk	128	4	deformability	deformability	NN
cord-018764-02l423mk	128	5	happens	happen	VBZ
cord-018764-02l423mk	128	6	to	to	IN
cord-018764-02l423mk	128	7	both	both	CC
cord-018764-02l423mk	128	8	infected	infected	JJ
cord-018764-02l423mk	128	9	and	and	CC
cord-018764-02l423mk	128	10	non	non	JJ
cord-018764-02l423mk	128	11	-	-	JJ
cord-018764-02l423mk	128	12	infected	infected	JJ
cord-018764-02l423mk	128	13	red	red	JJ
cord-018764-02l423mk	128	14	cells	cell	NNS
cord-018764-02l423mk	128	15	in	in	IN
cord-018764-02l423mk	128	16	malaria	malaria	NN
cord-018764-02l423mk	128	17	,	,	,
cord-018764-02l423mk	128	18	whether	whether	IN
cord-018764-02l423mk	128	19	caused	cause	VBN
cord-018764-02l423mk	128	20	by	by	IN
cord-018764-02l423mk	128	21	P.	P.	NNP
cord-018764-02l423mk	128	22	vivax	vivax	NN
cord-018764-02l423mk	128	23	or	or	CC
cord-018764-02l423mk	128	24	P.	p.	NN
cord-018764-02l423mk	128	25	falciparum	falciparum	NN
cord-018764-02l423mk	128	26	.	.	.
cord-018764-02l423mk	129	1	Under	under	IN
cord-018764-02l423mk	129	2	physiological	physiological	JJ
cord-018764-02l423mk	129	3	conditions	condition	NNS
cord-018764-02l423mk	129	4	,	,	,
cord-018764-02l423mk	129	5	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	129	6	(	(	-LRB-
cord-018764-02l423mk	129	7	and	and	CC
cord-018764-02l423mk	129	8	other	other	JJ
cord-018764-02l423mk	129	9	cells	cell	NNS
cord-018764-02l423mk	129	10	)	)	-RRB-
cord-018764-02l423mk	129	11	control	control	VBP
cord-018764-02l423mk	129	12	the	the	DT
cord-018764-02l423mk	129	13	passive	passive	JJ
cord-018764-02l423mk	129	14	influx	influx	NN
cord-018764-02l423mk	129	15	of	of	IN
cord-018764-02l423mk	129	16	osmotic	osmotic	JJ
cord-018764-02l423mk	129	17	active	active	JJ
cord-018764-02l423mk	129	18	solutes	solute	NNS
cord-018764-02l423mk	129	19	(	(	-LRB-
cord-018764-02l423mk	129	20	especially	especially	RB
cord-018764-02l423mk	129	21	Na	Na	NNP
cord-018764-02l423mk	129	22	+	+	CC
cord-018764-02l423mk	129	23	)	)	-RRB-
cord-018764-02l423mk	129	24	via	via	IN
cord-018764-02l423mk	129	25	an	an	DT
cord-018764-02l423mk	129	26	active	active	JJ
cord-018764-02l423mk	129	27	,	,	,
cord-018764-02l423mk	129	28	energy	energy	NN
cord-018764-02l423mk	129	29	-	-	HYPH
cord-018764-02l423mk	129	30	dependent	dependent	JJ
cord-018764-02l423mk	129	31	elimination	elimination	NN
cord-018764-02l423mk	129	32	of	of	IN
cord-018764-02l423mk	129	33	these	these	DT
cord-018764-02l423mk	129	34	solutes	solute	NNS
cord-018764-02l423mk	129	35	using	use	VBG
cord-018764-02l423mk	129	36	Na	Na	NNP
cord-018764-02l423mk	129	37	+	+	CC
cord-018764-02l423mk	129	38	/K	/K	.
cord-018764-02l423mk	130	1	+	+	CC
cord-018764-02l423mk	131	1	-ATPase	-ATPase	NNP
cord-018764-02l423mk	131	2	.	.	.
cord-018764-02l423mk	132	1	This	this	DT
cord-018764-02l423mk	132	2	prevents	prevent	VBZ
cord-018764-02l423mk	132	3	intracellular	intracellular	JJ
cord-018764-02l423mk	132	4	accumulation	accumulation	NN
cord-018764-02l423mk	132	5	of	of	IN
cord-018764-02l423mk	132	6	osmotically	osmotically	RB
cord-018764-02l423mk	132	7	active	active	JJ
cord-018764-02l423mk	132	8	solutes	solute	NNS
cord-018764-02l423mk	132	9	,	,	,
cord-018764-02l423mk	132	10	preventing	prevent	VBG
cord-018764-02l423mk	132	11	a	a	DT
cord-018764-02l423mk	132	12	subsequent	subsequent	JJ
cord-018764-02l423mk	132	13	influx	influx	NN
cord-018764-02l423mk	132	14	of	of	IN
cord-018764-02l423mk	132	15	water	water	NN
cord-018764-02l423mk	132	16	,	,	,
cord-018764-02l423mk	132	17	cell	cell	NN
cord-018764-02l423mk	132	18	swelling	swelling	NN
cord-018764-02l423mk	132	19	and	and	CC
cord-018764-02l423mk	132	20	loss	loss	NN
cord-018764-02l423mk	132	21	of	of	IN
cord-018764-02l423mk	132	22	cell	cell	NN
cord-018764-02l423mk	132	23	integrity	integrity	NN
cord-018764-02l423mk	132	24	.	.	.
cord-018764-02l423mk	133	1	During	during	IN
cord-018764-02l423mk	133	2	human	human	JJ
cord-018764-02l423mk	133	3	[	[	-LRB-
cord-018764-02l423mk	133	4	69	69	CD
cord-018764-02l423mk	133	5	]	]	-RRB-
cord-018764-02l423mk	133	6	and	and	CC
cord-018764-02l423mk	133	7	monkey	monkey	NN
cord-018764-02l423mk	133	8	[	[	-LRB-
cord-018764-02l423mk	133	9	70	70	CD
cord-018764-02l423mk	133	10	]	]	-RRB-
cord-018764-02l423mk	133	11	malaria	malaria	NN
cord-018764-02l423mk	133	12	infection	infection	NN
cord-018764-02l423mk	133	13	,	,	,
cord-018764-02l423mk	133	14	intracellular	intracellular	JJ
cord-018764-02l423mk	133	15	Na	Na	NNP
cord-018764-02l423mk	133	16	+	+	CC
cord-018764-02l423mk	133	17	accumulates	accumulate	VBZ
cord-018764-02l423mk	133	18	within	within	IN
cord-018764-02l423mk	133	19	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	133	20	(	(	-LRB-
cord-018764-02l423mk	133	21	both	both	DT
cord-018764-02l423mk	133	22	parasitised	parasitised	JJ
cord-018764-02l423mk	133	23	and	and	CC
cord-018764-02l423mk	133	24	non	non	JJ
cord-018764-02l423mk	133	25	-	-	JJ
cord-018764-02l423mk	133	26	parasitised	parasitised	JJ
cord-018764-02l423mk	133	27	)	)	-RRB-
cord-018764-02l423mk	133	28	implying	imply	VBG
cord-018764-02l423mk	133	29	that	that	IN
cord-018764-02l423mk	133	30	this	this	DT
cord-018764-02l423mk	133	31	Na	Na	NNP
cord-018764-02l423mk	133	32	+	+	CC
cord-018764-02l423mk	133	33	/K	/k	NN
cord-018764-02l423mk	133	34	+	+	CC
cord-018764-02l423mk	133	35	pump	pump	NN
cord-018764-02l423mk	133	36	is	be	VBZ
cord-018764-02l423mk	133	37	impaired	impair	VBN
cord-018764-02l423mk	133	38	during	during	IN
cord-018764-02l423mk	133	39	the	the	DT
cord-018764-02l423mk	133	40	disease	disease	NN
cord-018764-02l423mk	133	41	process	process	NN
cord-018764-02l423mk	133	42	.	.	.
cord-018764-02l423mk	134	1	Parallel	parallel	JJ
cord-018764-02l423mk	134	2	changes	change	NNS
cord-018764-02l423mk	134	3	in	in	IN
cord-018764-02l423mk	134	4	the	the	DT
cord-018764-02l423mk	134	5	ionic	ionic	JJ
cord-018764-02l423mk	134	6	content	content	NN
cord-018764-02l423mk	134	7	of	of	IN
cord-018764-02l423mk	134	8	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	134	9	have	have	VBP
cord-018764-02l423mk	134	10	been	be	VBN
cord-018764-02l423mk	134	11	documented	document	VBN
cord-018764-02l423mk	134	12	in	in	IN
cord-018764-02l423mk	134	13	a	a	DT
cord-018764-02l423mk	134	14	sepsis	sepsis	NN
cord-018764-02l423mk	134	15	model	model	NN
cord-018764-02l423mk	134	16	of	of	IN
cord-018764-02l423mk	134	17	infection	infection	NN
cord-018764-02l423mk	134	18	[	[	-LRB-
cord-018764-02l423mk	134	19	71	71	CD
cord-018764-02l423mk	134	20	]	]	-RRB-
cord-018764-02l423mk	134	21	.	.	.
cord-018764-02l423mk	135	1	Similarly	similarly	RB
cord-018764-02l423mk	135	2	,	,	,
cord-018764-02l423mk	135	3	reduction	reduction	NN
cord-018764-02l423mk	135	4	in	in	IN
cord-018764-02l423mk	135	5	erythrocyte	erythrocyte	NN
cord-018764-02l423mk	135	6	deformability	deformability	NN
cord-018764-02l423mk	135	7	was	be	VBD
cord-018764-02l423mk	135	8	shown	show	VBN
cord-018764-02l423mk	135	9	to	to	TO
cord-018764-02l423mk	135	10	be	be	VB
cord-018764-02l423mk	135	11	associated	associate	VBN
cord-018764-02l423mk	135	12	with	with	IN
cord-018764-02l423mk	135	13	increased	increase	VBN
cord-018764-02l423mk	135	14	NO	no	UH
cord-018764-02l423mk	135	15	,	,	,
cord-018764-02l423mk	135	16	an	an	DT
cord-018764-02l423mk	135	17	inhibitor	inhibitor	NN
cord-018764-02l423mk	135	18	of	of	IN
cord-018764-02l423mk	135	19	this	this	DT
cord-018764-02l423mk	135	20	membrane	membrane	NN
cord-018764-02l423mk	135	21	pump	pump	NN
cord-018764-02l423mk	135	22	[	[	-LRB-
cord-018764-02l423mk	135	23	72	72	CD
cord-018764-02l423mk	135	24	]	]	-RRB-
cord-018764-02l423mk	135	25	,	,	,
cord-018764-02l423mk	135	26	in	in	IN
cord-018764-02l423mk	135	27	another	another	DT
cord-018764-02l423mk	135	28	sepsis	sepsis	NN
cord-018764-02l423mk	135	29	model	model	NN
cord-018764-02l423mk	135	30	[	[	-LRB-
cord-018764-02l423mk	135	31	73	73	CD
cord-018764-02l423mk	135	32	]	]	-RRB-
cord-018764-02l423mk	135	33	.	.	.
cord-018764-02l423mk	136	1	Since	since	IN
cord-018764-02l423mk	136	2	inhibition	inhibition	NN
cord-018764-02l423mk	136	3	of	of	IN
cord-018764-02l423mk	136	4	the	the	DT
cord-018764-02l423mk	136	5	Na	Na	NNP
cord-018764-02l423mk	136	6	+	+	CC
cord-018764-02l423mk	136	7	/K	/k	NN
cord-018764-02l423mk	136	8	+	+	CC
cord-018764-02l423mk	136	9	pump	pump	VB
cord-018764-02l423mk	136	10	in	in	IN
cord-018764-02l423mk	136	11	vitro	vitro	FW
cord-018764-02l423mk	136	12	correlates	correlate	VBZ
cord-018764-02l423mk	136	13	with	with	IN
cord-018764-02l423mk	136	14	both	both	CC
cord-018764-02l423mk	136	15	reduced	reduce	VBN
cord-018764-02l423mk	136	16	red	red	JJ
cord-018764-02l423mk	136	17	cell	cell	NN
cord-018764-02l423mk	136	18	deformability	deformability	NN
cord-018764-02l423mk	136	19	and	and	CC
cord-018764-02l423mk	136	20	decreased	decrease	VBD
cord-018764-02l423mk	136	21	red	red	JJ
cord-018764-02l423mk	136	22	cell	cell	NN
cord-018764-02l423mk	136	23	filterability	filterability	NN
cord-018764-02l423mk	136	24	[	[	-LRB-
cord-018764-02l423mk	136	25	74	74	CD
cord-018764-02l423mk	136	26	]	]	-RRB-
cord-018764-02l423mk	136	27	,	,	,
cord-018764-02l423mk	136	28	any	any	DT
cord-018764-02l423mk	136	29	factor	factor	NN
cord-018764-02l423mk	136	30	that	that	WDT
cord-018764-02l423mk	136	31	inhibits	inhibit	VBZ
cord-018764-02l423mk	136	32	the	the	DT
cord-018764-02l423mk	136	33	Na	Na	NNP
cord-018764-02l423mk	136	34	+	+	CC
cord-018764-02l423mk	136	35	/K	/k	NN
cord-018764-02l423mk	136	36	+	+	CC
cord-018764-02l423mk	136	37	pump	pump	NN
cord-018764-02l423mk	136	38	could	could	MD
cord-018764-02l423mk	136	39	potentially	potentially	RB
cord-018764-02l423mk	136	40	worsen	worsen	VB
cord-018764-02l423mk	136	41	anaemia	anaemia	NN
cord-018764-02l423mk	136	42	.	.	.
cord-018764-02l423mk	137	1	Identification	identification	NN
cord-018764-02l423mk	137	2	of	of	IN
cord-018764-02l423mk	137	3	inducible	inducible	JJ
cord-018764-02l423mk	137	4	NO	no	DT
cord-018764-02l423mk	137	5	synthase	synthase	NN
cord-018764-02l423mk	137	6	(	(	-LRB-
cord-018764-02l423mk	137	7	iNOS	inos	NN
cord-018764-02l423mk	137	8	)	)	-RRB-
cord-018764-02l423mk	137	9	activity	activity	NN
cord-018764-02l423mk	137	10	,	,	,
cord-018764-02l423mk	137	11	as	as	IN
cord-018764-02l423mk	137	12	one	one	CD
cord-018764-02l423mk	137	13	factor	factor	NN
cord-018764-02l423mk	137	14	influencing	influence	VBG
cord-018764-02l423mk	137	15	red	red	JJ
cord-018764-02l423mk	137	16	cell	cell	NN
cord-018764-02l423mk	137	17	deformability	deformability	NN
cord-018764-02l423mk	137	18	,	,	,
cord-018764-02l423mk	137	19	suggests	suggest	VBZ
cord-018764-02l423mk	137	20	that	that	IN
cord-018764-02l423mk	137	21	a	a	DT
cord-018764-02l423mk	137	22	pro	pro	JJ
cord-018764-02l423mk	137	23	-	-	JJ
cord-018764-02l423mk	137	24	inflammatory	inflammatory	JJ
cord-018764-02l423mk	137	25	milieu	milieu	NN
cord-018764-02l423mk	137	26	[	[	-LRB-
cord-018764-02l423mk	137	27	75	75	CD
cord-018764-02l423mk	137	28	]	]	-RRB-
cord-018764-02l423mk	137	29	may	may	MD
cord-018764-02l423mk	137	30	again	again	RB
cord-018764-02l423mk	137	31	govern	govern	VB
cord-018764-02l423mk	137	32	the	the	DT
cord-018764-02l423mk	137	33	reduction	reduction	NN
cord-018764-02l423mk	137	34	in	in	IN
cord-018764-02l423mk	137	35	red	red	JJ
cord-018764-02l423mk	137	36	cell	cell	NN
cord-018764-02l423mk	137	37	deformability	deformability	NN
cord-018764-02l423mk	137	38	observed	observe	VBD
cord-018764-02l423mk	137	39	during	during	IN
cord-018764-02l423mk	137	40	malaria	malaria	NN
cord-018764-02l423mk	137	41	infection	infection	NN
cord-018764-02l423mk	137	42	.	.	.
cord-018764-02l423mk	138	1	Originally	originally	RB
cord-018764-02l423mk	138	2	observed	observe	VBN
cord-018764-02l423mk	138	3	in	in	IN
cord-018764-02l423mk	138	4	uraemic	uraemic	JJ
cord-018764-02l423mk	138	5	patients	patient	NNS
cord-018764-02l423mk	138	6	,	,	,
cord-018764-02l423mk	138	7	poor	poor	JJ
cord-018764-02l423mk	138	8	red	red	JJ
cord-018764-02l423mk	138	9	cell	cell	NN
cord-018764-02l423mk	138	10	deformability	deformability	NN
cord-018764-02l423mk	138	11	was	be	VBD
cord-018764-02l423mk	138	12	recognised	recognise	VBN
cord-018764-02l423mk	138	13	in	in	IN
cord-018764-02l423mk	138	14	a	a	DT
cord-018764-02l423mk	138	15	small	small	JJ
cord-018764-02l423mk	138	16	pilot	pilot	NN
cord-018764-02l423mk	138	17	study	study	NN
cord-018764-02l423mk	138	18	of	of	IN
cord-018764-02l423mk	138	19	malaria	malaria	NN
cord-018764-02l423mk	138	20	patients	patient	NNS
cord-018764-02l423mk	138	21	in	in	IN
cord-018764-02l423mk	138	22	1985	1985	CD
cord-018764-02l423mk	138	23	[	[	-LRB-
cord-018764-02l423mk	138	24	76	76	CD
cord-018764-02l423mk	138	25	]	]	-RRB-
cord-018764-02l423mk	138	26	.	.	.
cord-018764-02l423mk	139	1	It	-PRON-	PRP
cord-018764-02l423mk	139	2	was	be	VBD
cord-018764-02l423mk	139	3	reported	report	VBN
cord-018764-02l423mk	139	4	soon	soon	RB
cord-018764-02l423mk	139	5	afterwards	afterwards	RB
cord-018764-02l423mk	139	6	in	in	IN
cord-018764-02l423mk	139	7	sepsis	sepsis	NN
cord-018764-02l423mk	139	8	[	[	-LRB-
cord-018764-02l423mk	139	9	77	77	CD
cord-018764-02l423mk	139	10	,	,	,
cord-018764-02l423mk	139	11	78	78	CD
cord-018764-02l423mk	139	12	]	]	-RRB-
cord-018764-02l423mk	139	13	,	,	,
cord-018764-02l423mk	139	14	and	and	CC
cord-018764-02l423mk	139	15	subsequently	subsequently	RB
cord-018764-02l423mk	139	16	studied	study	VBN
cord-018764-02l423mk	139	17	in	in	IN
cord-018764-02l423mk	139	18	falciparum	falciparum	NN
cord-018764-02l423mk	139	19	malaria	malaria	NN
cord-018764-02l423mk	139	20	with	with	IN
cord-018764-02l423mk	139	21	a	a	DT
cord-018764-02l423mk	139	22	view	view	NN
cord-018764-02l423mk	139	23	to	to	IN
cord-018764-02l423mk	139	24	understanding	understand	VBG
cord-018764-02l423mk	139	25	both	both	DT
cord-018764-02l423mk	139	26	circulatory	circulatory	JJ
cord-018764-02l423mk	139	27	obstruction	obstruction	NN
cord-018764-02l423mk	139	28	[	[	-LRB-
cord-018764-02l423mk	139	29	79	79	CD
cord-018764-02l423mk	139	30	]	]	-RRB-
cord-018764-02l423mk	139	31	and	and	CC
cord-018764-02l423mk	139	32	anaemia	anaemia	NN
cord-018764-02l423mk	139	33	[	[	-LRB-
cord-018764-02l423mk	139	34	80	80	CD
cord-018764-02l423mk	139	35	]	]	-RRB-
cord-018764-02l423mk	139	36	.	.	.
cord-018764-02l423mk	140	1	It	-PRON-	PRP
cord-018764-02l423mk	140	2	seems	seem	VBZ
cord-018764-02l423mk	140	3	clear	clear	JJ
cord-018764-02l423mk	140	4	that	that	IN
cord-018764-02l423mk	140	5	a	a	DT
cord-018764-02l423mk	140	6	short	short	JJ
cord-018764-02l423mk	140	7	life	life	NN
cord-018764-02l423mk	140	8	(	(	-LRB-
cord-018764-02l423mk	140	9	poor	poor	JJ
cord-018764-02l423mk	140	10	deformability	deformability	NN
cord-018764-02l423mk	140	11	)	)	-RRB-
cord-018764-02l423mk	140	12	,	,	,
cord-018764-02l423mk	140	13	and	and	CC
cord-018764-02l423mk	140	14	a	a	DT
cord-018764-02l423mk	140	15	slow	slow	JJ
cord-018764-02l423mk	140	16	replacement	replacement	NN
cord-018764-02l423mk	140	17	rate	rate	NN
cord-018764-02l423mk	140	18	(	(	-LRB-
cord-018764-02l423mk	140	19	dyserythropoiesis	dyserythropoiesis	NN
cord-018764-02l423mk	140	20	,	,	,
cord-018764-02l423mk	140	21	below	below	RB
cord-018764-02l423mk	140	22	)	)	-RRB-
cord-018764-02l423mk	140	23	can	can	MD
cord-018764-02l423mk	140	24	combine	combine	VB
cord-018764-02l423mk	140	25	to	to	TO
cord-018764-02l423mk	140	26	cause	cause	VB
cord-018764-02l423mk	140	27	severe	severe	JJ
cord-018764-02l423mk	140	28	anaemia	anaemia	NN
cord-018764-02l423mk	140	29	in	in	IN
cord-018764-02l423mk	140	30	various	various	JJ
cord-018764-02l423mk	140	31	diseases	disease	NNS
cord-018764-02l423mk	140	32	,	,	,
cord-018764-02l423mk	140	33	particularly	particularly	RB
cord-018764-02l423mk	140	34	in	in	IN
cord-018764-02l423mk	140	35	chronic	chronic	JJ
cord-018764-02l423mk	140	36	infections	infection	NNS
cord-018764-02l423mk	140	37	such	such	JJ
cord-018764-02l423mk	140	38	as	as	IN
cord-018764-02l423mk	140	39	malaria	malaria	NN
cord-018764-02l423mk	140	40	.	.	.
cord-018764-02l423mk	141	1	When	when	WRB
cord-018764-02l423mk	141	2	red	red	JJ
cord-018764-02l423mk	141	3	cells	cell	NNS
cord-018764-02l423mk	141	4	have	have	VBP
cord-018764-02l423mk	141	5	a	a	DT
cord-018764-02l423mk	141	6	shortened	shorten	VBN
cord-018764-02l423mk	141	7	lifespan	lifespan	NN
cord-018764-02l423mk	141	8	,	,	,
cord-018764-02l423mk	141	9	e.g.	e.g.	RB
cord-018764-02l423mk	141	10	secondary	secondary	JJ
cord-018764-02l423mk	141	11	to	to	IN
cord-018764-02l423mk	141	12	reduced	reduce	VBN
cord-018764-02l423mk	141	13	erythrocyte	erythrocyte	NN
cord-018764-02l423mk	141	14	deformability	deformability	NN
cord-018764-02l423mk	141	15	,	,	,
cord-018764-02l423mk	141	16	replacement	replacement	NN
cord-018764-02l423mk	141	17	by	by	IN
cord-018764-02l423mk	141	18	new	new	JJ
cord-018764-02l423mk	141	19	recruits	recruit	NNS
cord-018764-02l423mk	141	20	is	be	VBZ
cord-018764-02l423mk	141	21	vital	vital	JJ
cord-018764-02l423mk	141	22	to	to	TO
cord-018764-02l423mk	141	23	avoid	avoid	VB
cord-018764-02l423mk	141	24	anaemia	anaemia	NN
cord-018764-02l423mk	141	25	.	.	.
cord-018764-02l423mk	142	1	Unfortunately	unfortunately	RB
cord-018764-02l423mk	142	2	,	,	,
cord-018764-02l423mk	142	3	the	the	DT
cord-018764-02l423mk	142	4	same	same	JJ
cord-018764-02l423mk	142	5	inflammatory	inflammatory	JJ
cord-018764-02l423mk	142	6	cytokines	cytokine	NNS
cord-018764-02l423mk	142	7	that	that	WDT
cord-018764-02l423mk	142	8	shorten	shorten	VBP
cord-018764-02l423mk	142	9	lifespan	lifespan	NN
cord-018764-02l423mk	142	10	also	also	RB
cord-018764-02l423mk	142	11	retard	retard	VBP
cord-018764-02l423mk	142	12	replacement	replacement	NN
cord-018764-02l423mk	142	13	.	.	.
cord-018764-02l423mk	143	1	Some	some	DT
cord-018764-02l423mk	143	2	years	year	NNS
cord-018764-02l423mk	143	3	ago	ago	IN
cord-018764-02l423mk	143	4	researchers	researcher	NNS
cord-018764-02l423mk	143	5	began	begin	VBD
cord-018764-02l423mk	143	6	to	to	TO
cord-018764-02l423mk	143	7	stress	stress	VB
cord-018764-02l423mk	143	8	the	the	DT
cord-018764-02l423mk	143	9	contribution	contribution	NN
cord-018764-02l423mk	143	10	of	of	IN
cord-018764-02l423mk	143	11	bone	bone	NN
cord-018764-02l423mk	143	12	marrow	marrow	NN
cord-018764-02l423mk	143	13	dyserythropoiesis	dyserythropoiesis	NN
cord-018764-02l423mk	143	14	to	to	IN
cord-018764-02l423mk	143	15	the	the	DT
cord-018764-02l423mk	143	16	anaemia	anaemia	NN
cord-018764-02l423mk	143	17	of	of	IN
cord-018764-02l423mk	143	18	falciparum	falciparum	NN
cord-018764-02l423mk	143	19	malaria	malaria	NN
cord-018764-02l423mk	143	20	[	[	-LRB-
cord-018764-02l423mk	143	21	81	81	CD
cord-018764-02l423mk	143	22	,	,	,
cord-018764-02l423mk	143	23	82	82	CD
cord-018764-02l423mk	143	24	]	]	-RRB-
cord-018764-02l423mk	143	25	.	.	.
cord-018764-02l423mk	144	1	A	a	DT
cord-018764-02l423mk	144	2	group	group	NN
cord-018764-02l423mk	144	3	in	in	IN
cord-018764-02l423mk	144	4	Oxford	Oxford	NNP
cord-018764-02l423mk	144	5	[	[	-LRB-
cord-018764-02l423mk	144	6	83	83	CD
cord-018764-02l423mk	144	7	]	]	-RRB-
cord-018764-02l423mk	144	8	,	,	,
cord-018764-02l423mk	144	9	seeking	seek	VBG
cord-018764-02l423mk	144	10	an	an	DT
cord-018764-02l423mk	144	11	explanation	explanation	NN
cord-018764-02l423mk	144	12	for	for	IN
cord-018764-02l423mk	144	13	this	this	DT
cord-018764-02l423mk	144	14	dyserythropoiesis	dyserythropoiesis	NN
cord-018764-02l423mk	144	15	through	through	IN
cord-018764-02l423mk	144	16	an	an	DT
cord-018764-02l423mk	144	17	electron	electron	NN
cord-018764-02l423mk	144	18	microscopy	microscopy	NN
cord-018764-02l423mk	144	19	study	study	NN
cord-018764-02l423mk	144	20	of	of	IN
cord-018764-02l423mk	144	21	bone	bone	NN
cord-018764-02l423mk	144	22	marrow	marrow	NN
cord-018764-02l423mk	144	23	,	,	,
cord-018764-02l423mk	144	24	observed	observe	VBD
cord-018764-02l423mk	144	25	sequestration	sequestration	NN
cord-018764-02l423mk	144	26	of	of	IN
cord-018764-02l423mk	144	27	parasitised	parasitised	JJ
cord-018764-02l423mk	144	28	red	red	JJ
cord-018764-02l423mk	144	29	cells	cell	NNS
cord-018764-02l423mk	144	30	and	and	CC
cord-018764-02l423mk	144	31	argued	argue	VBD
cord-018764-02l423mk	144	32	that	that	IN
cord-018764-02l423mk	144	33	this	this	DT
cord-018764-02l423mk	144	34	caused	cause	VBD
cord-018764-02l423mk	144	35	the	the	DT
cord-018764-02l423mk	144	36	bone	bone	NN
cord-018764-02l423mk	144	37	marrow	marrow	NN
cord-018764-02l423mk	144	38	dysfunction	dysfunction	NN
cord-018764-02l423mk	144	39	in	in	IN
cord-018764-02l423mk	144	40	falciparum	falciparum	NN
cord-018764-02l423mk	144	41	malaria	malaria	NN
cord-018764-02l423mk	144	42	by	by	IN
cord-018764-02l423mk	144	43	restricting	restrict	VBG
cord-018764-02l423mk	144	44	blood	blood	NN
cord-018764-02l423mk	144	45	flow	flow	NN
cord-018764-02l423mk	144	46	and	and	CC
cord-018764-02l423mk	144	47	thus	thus	RB
cord-018764-02l423mk	144	48	inducing	induce	VBG
cord-018764-02l423mk	144	49	hypoxic	hypoxic	JJ
cord-018764-02l423mk	144	50	changes	change	NNS
cord-018764-02l423mk	144	51	.	.	.
cord-018764-02l423mk	145	1	This	this	DT
cord-018764-02l423mk	145	2	idea	idea	NN
cord-018764-02l423mk	145	3	proved	prove	VBD
cord-018764-02l423mk	145	4	inadequate	inadequate	JJ
cord-018764-02l423mk	145	5	,	,	,
cord-018764-02l423mk	145	6	however	however	RB
cord-018764-02l423mk	145	7	,	,	,
cord-018764-02l423mk	145	8	when	when	WRB
cord-018764-02l423mk	145	9	this	this	DT
cord-018764-02l423mk	145	10	same	same	JJ
cord-018764-02l423mk	145	11	group	group	NN
cord-018764-02l423mk	145	12	subsequently	subsequently	RB
cord-018764-02l423mk	145	13	reported	report	VBD
cord-018764-02l423mk	145	14	dyserythropoiesis	dyserythropoiesis	NN
cord-018764-02l423mk	145	15	and	and	CC
cord-018764-02l423mk	145	16	erythrophagocytosis	erythrophagocytosis	NN
cord-018764-02l423mk	145	17	in	in	IN
cord-018764-02l423mk	145	18	vivax	vivax	JJ
cord-018764-02l423mk	145	19	malaria	malaria	NN
cord-018764-02l423mk	145	20	,	,	,
cord-018764-02l423mk	145	21	in	in	IN
cord-018764-02l423mk	145	22	which	which	WDT
cord-018764-02l423mk	145	23	parasitised	parasitise	VBN
cord-018764-02l423mk	145	24	red	red	JJ
cord-018764-02l423mk	145	25	cells	cell	NNS
cord-018764-02l423mk	145	26	do	do	VBP
cord-018764-02l423mk	145	27	not	not	RB
cord-018764-02l423mk	145	28	sequester	sequester	VB
cord-018764-02l423mk	145	29	[	[	-LRB-
cord-018764-02l423mk	145	30	84	84	CD
cord-018764-02l423mk	145	31	]	]	-RRB-
cord-018764-02l423mk	145	32	.	.	.
cord-018764-02l423mk	146	1	Some	some	DT
cord-018764-02l423mk	146	2	time	time	NN
cord-018764-02l423mk	146	3	ago	ago	RB
cord-018764-02l423mk	146	4	an	an	DT
cord-018764-02l423mk	146	5	undefined	undefined	JJ
cord-018764-02l423mk	146	6	product	product	NN
cord-018764-02l423mk	146	7	in	in	IN
cord-018764-02l423mk	146	8	macrophage	macrophage	NN
cord-018764-02l423mk	146	9	supernatants	supernatant	NNS
cord-018764-02l423mk	146	10	[	[	-LRB-
cord-018764-02l423mk	146	11	85	85	CD
cord-018764-02l423mk	146	12	]	]	-RRB-
cord-018764-02l423mk	146	13	,	,	,
cord-018764-02l423mk	146	14	later	later	RB
cord-018764-02l423mk	146	15	identified	identify	VBN
cord-018764-02l423mk	146	16	as	as	IN
cord-018764-02l423mk	146	17	TNF	TNF	NNP
cord-018764-02l423mk	146	18	[	[	-LRB-
cord-018764-02l423mk	146	19	86	86	CD
cord-018764-02l423mk	146	20	]	]	-RRB-
cord-018764-02l423mk	146	21	,	,	,
cord-018764-02l423mk	146	22	was	be	VBD
cord-018764-02l423mk	146	23	found	find	VBN
cord-018764-02l423mk	146	24	to	to	TO
cord-018764-02l423mk	146	25	inhibit	inhibit	VB
cord-018764-02l423mk	146	26	the	the	DT
cord-018764-02l423mk	146	27	growth	growth	NN
cord-018764-02l423mk	146	28	and	and	CC
cord-018764-02l423mk	146	29	differentiation	differentiation	NN
cord-018764-02l423mk	146	30	of	of	IN
cord-018764-02l423mk	146	31	erythroid	erythroid	JJ
cord-018764-02l423mk	146	32	progenitor	progenitor	NN
cord-018764-02l423mk	146	33	cells	cell	NNS
cord-018764-02l423mk	146	34	.	.	.
cord-018764-02l423mk	147	1	When	when	WRB
cord-018764-02l423mk	147	2	rTNF	rTNF	NNP
cord-018764-02l423mk	147	3	became	become	VBD
cord-018764-02l423mk	147	4	available	available	JJ
cord-018764-02l423mk	147	5	,	,	,
cord-018764-02l423mk	147	6	the	the	DT
cord-018764-02l423mk	147	7	dyserythropoiesis	dyserythropoiesis	NN
cord-018764-02l423mk	147	8	and	and	CC
cord-018764-02l423mk	147	9	erythrophagocytosis	erythrophagocytosis	NNP
cord-018764-02l423mk	147	10	seen	see	VBN
cord-018764-02l423mk	147	11	in	in	IN
cord-018764-02l423mk	147	12	terminal	terminal	JJ
cord-018764-02l423mk	147	13	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	147	14	vinckei	vinckei	NN
cord-018764-02l423mk	147	15	-	-	HYPH
cord-018764-02l423mk	147	16	infected	infect	VBN
cord-018764-02l423mk	147	17	mice	mouse	NNS
cord-018764-02l423mk	147	18	was	be	VBD
cord-018764-02l423mk	147	19	reproduced	reproduce	VBN
cord-018764-02l423mk	147	20	by	by	IN
cord-018764-02l423mk	147	21	giving	give	VBG
cord-018764-02l423mk	147	22	a	a	DT
cord-018764-02l423mk	147	23	single	single	JJ
cord-018764-02l423mk	147	24	injection	injection	NN
cord-018764-02l423mk	147	25	early	early	RB
cord-018764-02l423mk	147	26	in	in	IN
cord-018764-02l423mk	147	27	the	the	DT
cord-018764-02l423mk	147	28	course	course	NN
cord-018764-02l423mk	147	29	of	of	IN
cord-018764-02l423mk	147	30	the	the	DT
cord-018764-02l423mk	147	31	infection	infection	NN
cord-018764-02l423mk	147	32	[	[	-LRB-
cord-018764-02l423mk	147	33	87	87	CD
cord-018764-02l423mk	147	34	]	]	-RRB-
cord-018764-02l423mk	147	35	.	.	.
cord-018764-02l423mk	148	1	Phagocytosis	Phagocytosis	NNP
cord-018764-02l423mk	148	2	of	of	IN
cord-018764-02l423mk	148	3	erythroblasts	erythroblast	NNS
cord-018764-02l423mk	148	4	in	in	IN
cord-018764-02l423mk	148	5	bone	bone	NN
cord-018764-02l423mk	148	6	marrow	marrow	NN
cord-018764-02l423mk	148	7	,	,	,
cord-018764-02l423mk	148	8	a	a	DT
cord-018764-02l423mk	148	9	phenomenon	phenomenon	NN
cord-018764-02l423mk	148	10	also	also	RB
cord-018764-02l423mk	148	11	reported	report	VBN
cord-018764-02l423mk	148	12	by	by	IN
cord-018764-02l423mk	148	13	Wickramasinghe	Wickramasinghe	NNP
cord-018764-02l423mk	148	14	et	et	NNP
cord-018764-02l423mk	148	15	al	al	NNP
cord-018764-02l423mk	148	16	[	[	-LRB-
cord-018764-02l423mk	148	17	83	83	CD
cord-018764-02l423mk	148	18	,	,	,
cord-018764-02l423mk	148	19	84	84	CD
cord-018764-02l423mk	148	20	]	]	-RRB-
cord-018764-02l423mk	148	21	in	in	IN
cord-018764-02l423mk	148	22	human	human	JJ
cord-018764-02l423mk	148	23	malaria	malaria	NN
cord-018764-02l423mk	148	24	,	,	,
cord-018764-02l423mk	148	25	also	also	RB
cord-018764-02l423mk	148	26	occurred	occur	VBD
cord-018764-02l423mk	148	27	.	.	.
cord-018764-02l423mk	149	1	Decreased	decrease	VBN
cord-018764-02l423mk	149	2	erythropoiesis	erythropoiesis	NN
cord-018764-02l423mk	149	3	was	be	VBD
cord-018764-02l423mk	149	4	subsequently	subsequently	RB
cord-018764-02l423mk	149	5	reported	report	VBN
cord-018764-02l423mk	149	6	in	in	IN
cord-018764-02l423mk	149	7	mice	mouse	NNS
cord-018764-02l423mk	149	8	receiving	receive	VBG
cord-018764-02l423mk	149	9	continuous	continuous	JJ
cord-018764-02l423mk	149	10	TNF	TNF	NNP
cord-018764-02l423mk	149	11	infusions	infusion	NNS
cord-018764-02l423mk	149	12	via	via	IN
cord-018764-02l423mk	149	13	implanted	implant	VBN
cord-018764-02l423mk	149	14	osmotic	osmotic	JJ
cord-018764-02l423mk	149	15	pumps	pump	NNS
cord-018764-02l423mk	149	16	,	,	,
cord-018764-02l423mk	149	17	and	and	CC
cord-018764-02l423mk	149	18	mice	mouse	NNS
cord-018764-02l423mk	149	19	expressing	express	VBG
cord-018764-02l423mk	149	20	high	high	JJ
cord-018764-02l423mk	149	21	levels	level	NNS
cord-018764-02l423mk	149	22	of	of	IN
cord-018764-02l423mk	149	23	human	human	JJ
cord-018764-02l423mk	149	24	TNF	TNF	NNP
cord-018764-02l423mk	149	25	have	have	VBP
cord-018764-02l423mk	149	26	been	be	VBN
cord-018764-02l423mk	149	27	shown	show	VBN
cord-018764-02l423mk	149	28	to	to	TO
cord-018764-02l423mk	149	29	become	become	VB
cord-018764-02l423mk	149	30	markedly	markedly	RB
cord-018764-02l423mk	149	31	anaemic	anaemic	JJ
cord-018764-02l423mk	149	32	during	during	IN
cord-018764-02l423mk	149	33	malaria	malaria	NN
cord-018764-02l423mk	149	34	infections	infection	NNS
cord-018764-02l423mk	149	35	[	[	-LRB-
cord-018764-02l423mk	149	36	68	68	CD
cord-018764-02l423mk	149	37	]	]	-RRB-
cord-018764-02l423mk	149	38	,	,	,
cord-018764-02l423mk	149	39	even	even	RB
cord-018764-02l423mk	149	40	though	though	IN
cord-018764-02l423mk	149	41	parasite	parasite	JJ
cord-018764-02l423mk	149	42	numbers	number	NNS
cord-018764-02l423mk	149	43	,	,	,
cord-018764-02l423mk	149	44	and	and	CC
cord-018764-02l423mk	149	45	therefore	therefore	RB
cord-018764-02l423mk	149	46	red	red	JJ
cord-018764-02l423mk	149	47	cell	cell	NN
cord-018764-02l423mk	149	48	loss	loss	NN
cord-018764-02l423mk	149	49	post	post	NN
cord-018764-02l423mk	149	50	-	-	NN
cord-018764-02l423mk	149	51	schizogony	schizogony	JJ
cord-018764-02l423mk	149	52	,	,	,
cord-018764-02l423mk	149	53	are	be	VBP
cord-018764-02l423mk	149	54	considerably	considerably	RB
cord-018764-02l423mk	149	55	reduced	reduce	VBN
cord-018764-02l423mk	149	56	.	.	.
cord-018764-02l423mk	150	1	The	the	DT
cord-018764-02l423mk	150	2	past	past	JJ
cord-018764-02l423mk	150	3	decade	decade	NN
cord-018764-02l423mk	150	4	has	have	VBZ
cord-018764-02l423mk	150	5	seen	see	VBN
cord-018764-02l423mk	150	6	an	an	DT
cord-018764-02l423mk	150	7	expansion	expansion	NN
cord-018764-02l423mk	150	8	of	of	IN
cord-018764-02l423mk	150	9	this	this	DT
cord-018764-02l423mk	150	10	line	line	NN
cord-018764-02l423mk	150	11	of	of	IN
cord-018764-02l423mk	150	12	enquiry	enquiry	NN
cord-018764-02l423mk	150	13	into	into	IN
cord-018764-02l423mk	150	14	human	human	JJ
cord-018764-02l423mk	150	15	malaria	malaria	NN
cord-018764-02l423mk	150	16	,	,	,
cord-018764-02l423mk	150	17	and	and	CC
cord-018764-02l423mk	150	18	also	also	RB
cord-018764-02l423mk	150	19	the	the	DT
cord-018764-02l423mk	150	20	number	number	NN
cord-018764-02l423mk	150	21	of	of	IN
cord-018764-02l423mk	150	22	cytokines	cytokine	NNS
cord-018764-02l423mk	150	23	,	,	,
cord-018764-02l423mk	150	24	both	both	CC
cord-018764-02l423mk	150	25	pro	pro	JJ
cord-018764-02l423mk	150	26	-	-	JJ
cord-018764-02l423mk	150	27	inflammatory	inflammatory	JJ
cord-018764-02l423mk	150	28	and	and	CC
cord-018764-02l423mk	150	29	anti	anti	JJ
cord-018764-02l423mk	150	30	-	-	JJ
cord-018764-02l423mk	150	31	inflammatory	inflammatory	JJ
cord-018764-02l423mk	150	32	[	[	-LRB-
cord-018764-02l423mk	150	33	88	88	CD
cord-018764-02l423mk	150	34	,	,	,
cord-018764-02l423mk	150	35	89	89	CD
cord-018764-02l423mk	150	36	]	]	-RRB-
cord-018764-02l423mk	150	37	in	in	IN
cord-018764-02l423mk	150	38	absolute	absolute	JJ
cord-018764-02l423mk	150	39	amounts	amount	NNS
cord-018764-02l423mk	150	40	and	and	CC
cord-018764-02l423mk	150	41	ratios	ratio	NNS
cord-018764-02l423mk	150	42	[	[	-LRB-
cord-018764-02l423mk	150	43	90	90	CD
cord-018764-02l423mk	150	44	,	,	,
cord-018764-02l423mk	150	45	91	91	CD
cord-018764-02l423mk	150	46	]	]	-RRB-
cord-018764-02l423mk	150	47	,	,	,
cord-018764-02l423mk	150	48	that	that	WDT
cord-018764-02l423mk	150	49	have	have	VBP
cord-018764-02l423mk	150	50	been	be	VBN
cord-018764-02l423mk	150	51	investigated	investigate	VBN
cord-018764-02l423mk	150	52	in	in	IN
cord-018764-02l423mk	150	53	this	this	DT
cord-018764-02l423mk	150	54	context	context	NN
cord-018764-02l423mk	150	55	.	.	.
cord-018764-02l423mk	151	1	Investigations	investigation	NNS
cord-018764-02l423mk	151	2	have	have	VBP
cord-018764-02l423mk	151	3	been	be	VBN
cord-018764-02l423mk	151	4	extended	extend	VBN
cord-018764-02l423mk	151	5	to	to	TO
cord-018764-02l423mk	151	6	include	include	VB
cord-018764-02l423mk	151	7	other	other	JJ
cord-018764-02l423mk	151	8	pro	pro	JJ
cord-018764-02l423mk	151	9	-	-	JJ
cord-018764-02l423mk	151	10	inflammatory	inflammatory	JJ
cord-018764-02l423mk	151	11	cytokines	cytokine	NNS
cord-018764-02l423mk	151	12	,	,	,
cord-018764-02l423mk	151	13	such	such	JJ
cord-018764-02l423mk	151	14	as	as	IN
cord-018764-02l423mk	151	15	IL-12	IL-12	NNP
cord-018764-02l423mk	151	16	[	[	-LRB-
cord-018764-02l423mk	151	17	92	92	CD
cord-018764-02l423mk	151	18	]	]	-RRB-
cord-018764-02l423mk	151	19	and	and	CC
cord-018764-02l423mk	151	20	FasL	FasL	NNP
cord-018764-02l423mk	151	21	[	[	-LRB-
cord-018764-02l423mk	151	22	93	93	CD
cord-018764-02l423mk	151	23	]	]	-RRB-
cord-018764-02l423mk	151	24	,	,	,
cord-018764-02l423mk	151	25	and	and	CC
cord-018764-02l423mk	151	26	examined	examine	VBD
cord-018764-02l423mk	151	27	the	the	DT
cord-018764-02l423mk	151	28	role	role	NN
cord-018764-02l423mk	151	29	in	in	IN
cord-018764-02l423mk	151	30	anaemia	anaemia	NN
cord-018764-02l423mk	151	31	of	of	IN
cord-018764-02l423mk	151	32	the	the	DT
cord-018764-02l423mk	151	33	persistence	persistence	NN
cord-018764-02l423mk	151	34	of	of	IN
cord-018764-02l423mk	151	35	cytokine	cytokine	NN
cord-018764-02l423mk	151	36	production	production	NN
cord-018764-02l423mk	151	37	during	during	IN
cord-018764-02l423mk	151	38	malaria	malaria	NN
cord-018764-02l423mk	151	39	infection	infection	NN
cord-018764-02l423mk	151	40	[	[	-LRB-
cord-018764-02l423mk	151	41	94	94	CD
cord-018764-02l423mk	151	42	]	]	-RRB-
cord-018764-02l423mk	151	43	.	.	.
cord-018764-02l423mk	152	1	Another	another	DT
cord-018764-02l423mk	152	2	inflammatory	inflammatory	JJ
cord-018764-02l423mk	152	3	cytokine	cytokine	NN
cord-018764-02l423mk	152	4	,	,	,
cord-018764-02l423mk	152	5	macrophage	macrophage	NN
cord-018764-02l423mk	152	6	inhibitory	inhibitory	JJ
cord-018764-02l423mk	152	7	factor	factor	NN
cord-018764-02l423mk	152	8	(	(	-LRB-
cord-018764-02l423mk	152	9	MIF	MIF	NNP
cord-018764-02l423mk	152	10	)	)	-RRB-
cord-018764-02l423mk	152	11	that	that	WDT
cord-018764-02l423mk	152	12	is	be	VBZ
cord-018764-02l423mk	152	13	increased	increase	VBN
cord-018764-02l423mk	152	14	in	in	IN
cord-018764-02l423mk	152	15	malaria	malaria	NN
cord-018764-02l423mk	152	16	,	,	,
cord-018764-02l423mk	152	17	and	and	CC
cord-018764-02l423mk	152	18	induced	induce	VBN
cord-018764-02l423mk	152	19	by	by	IN
cord-018764-02l423mk	152	20	TNF	TNF	NNP
cord-018764-02l423mk	152	21	,	,	,
cord-018764-02l423mk	152	22	has	have	VBZ
cord-018764-02l423mk	152	23	been	be	VBN
cord-018764-02l423mk	152	24	shown	show	VBN
cord-018764-02l423mk	152	25	to	to	TO
cord-018764-02l423mk	152	26	cause	cause	VB
cord-018764-02l423mk	152	27	dyserythropoiesis	dyserythropoiesis	NN
cord-018764-02l423mk	152	28	in	in	IN
cord-018764-02l423mk	152	29	in	in	FW
cord-018764-02l423mk	152	30	vitro	vitro	FW
cord-018764-02l423mk	152	31	studies	study	NNS
cord-018764-02l423mk	152	32	on	on	IN
cord-018764-02l423mk	152	33	bone	bone	NN
cord-018764-02l423mk	152	34	marrow	marrow	NN
cord-018764-02l423mk	152	35	cells	cell	NNS
cord-018764-02l423mk	152	36	[	[	-LRB-
cord-018764-02l423mk	152	37	95	95	CD
cord-018764-02l423mk	152	38	,	,	,
cord-018764-02l423mk	152	39	96	96	CD
cord-018764-02l423mk	152	40	]	]	-RRB-
cord-018764-02l423mk	152	41	.	.	.
cord-018764-02l423mk	153	1	Thus	thus	RB
cord-018764-02l423mk	153	2	,	,	,
cord-018764-02l423mk	153	3	inflammatory	inflammatory	JJ
cord-018764-02l423mk	153	4	cytokines	cytokine	NNS
cord-018764-02l423mk	153	5	generated	generate	VBN
cord-018764-02l423mk	153	6	during	during	IN
cord-018764-02l423mk	153	7	malaria	malaria	NN
cord-018764-02l423mk	153	8	are	be	VBP
cord-018764-02l423mk	153	9	a	a	DT
cord-018764-02l423mk	153	10	major	major	JJ
cord-018764-02l423mk	153	11	determinant	determinant	NN
cord-018764-02l423mk	153	12	of	of	IN
cord-018764-02l423mk	153	13	the	the	DT
cord-018764-02l423mk	153	14	degree	degree	NN
cord-018764-02l423mk	153	15	to	to	TO
cord-018764-02l423mk	153	16	which	which	WDT
cord-018764-02l423mk	153	17	anaemia	anaemia	NN
cord-018764-02l423mk	153	18	influences	influence	VBZ
cord-018764-02l423mk	153	19	the	the	DT
cord-018764-02l423mk	153	20	amount	amount	NN
cord-018764-02l423mk	153	21	of	of	IN
cord-018764-02l423mk	153	22	oxygen	oxygen	NN
cord-018764-02l423mk	153	23	that	that	WDT
cord-018764-02l423mk	153	24	reaches	reach	VBZ
cord-018764-02l423mk	153	25	tissues	tissue	NNS
cord-018764-02l423mk	153	26	in	in	IN
cord-018764-02l423mk	153	27	malaria	malaria	NN
cord-018764-02l423mk	153	28	.	.	.
cord-018764-02l423mk	154	1	Mitochondria	mitochondrion	NNS
cord-018764-02l423mk	154	2	are	be	VBP
cord-018764-02l423mk	154	3	vital	vital	JJ
cord-018764-02l423mk	154	4	to	to	IN
cord-018764-02l423mk	154	5	energy	energy	NN
cord-018764-02l423mk	154	6	(	(	-LRB-
cord-018764-02l423mk	154	7	ATP	ATP	NNP
cord-018764-02l423mk	154	8	)	)	-RRB-
cord-018764-02l423mk	154	9	generation	generation	NN
cord-018764-02l423mk	154	10	through	through	IN
cord-018764-02l423mk	154	11	cellular	cellular	JJ
cord-018764-02l423mk	154	12	respiration	respiration	NN
cord-018764-02l423mk	154	13	.	.	.
cord-018764-02l423mk	155	1	Cellular	cellular	JJ
cord-018764-02l423mk	155	2	respiration	respiration	NN
cord-018764-02l423mk	155	3	requires	require	VBZ
cord-018764-02l423mk	155	4	oxygen	oxygen	NN
cord-018764-02l423mk	155	5	and	and	CC
cord-018764-02l423mk	155	6	pyruvate	pyruvate	NN
cord-018764-02l423mk	155	7	,	,	,
cord-018764-02l423mk	155	8	as	as	RB
cord-018764-02l423mk	155	9	well	well	RB
cord-018764-02l423mk	155	10	as	as	IN
cord-018764-02l423mk	155	11	multiple	multiple	JJ
cord-018764-02l423mk	155	12	cofactors	cofactor	NNS
cord-018764-02l423mk	155	13	and	and	CC
cord-018764-02l423mk	155	14	active	active	JJ
cord-018764-02l423mk	155	15	transport	transport	NN
cord-018764-02l423mk	155	16	molecules	molecule	NNS
cord-018764-02l423mk	155	17	.	.	.
cord-018764-02l423mk	156	1	Within	within	IN
cord-018764-02l423mk	156	2	the	the	DT
cord-018764-02l423mk	156	3	matrix	matrix	NN
cord-018764-02l423mk	156	4	of	of	IN
cord-018764-02l423mk	156	5	the	the	DT
cord-018764-02l423mk	156	6	mitochondrion	mitochondrion	NN
cord-018764-02l423mk	156	7	organelle	organelle	NN
cord-018764-02l423mk	156	8	,	,	,
cord-018764-02l423mk	156	9	pyruvate	pyruvate	NN
cord-018764-02l423mk	156	10	is	be	VBZ
cord-018764-02l423mk	156	11	catabolised	catabolise	VBN
cord-018764-02l423mk	156	12	via	via	IN
cord-018764-02l423mk	156	13	the	the	DT
cord-018764-02l423mk	156	14	Krebs	Krebs	NNP
cord-018764-02l423mk	156	15	cycle	cycle	NN
cord-018764-02l423mk	156	16	and	and	CC
cord-018764-02l423mk	156	17	oxidative	oxidative	JJ
cord-018764-02l423mk	156	18	phosphorylation	phosphorylation	NN
cord-018764-02l423mk	156	19	(	(	-LRB-
cord-018764-02l423mk	156	20	involving	involve	VBG
cord-018764-02l423mk	156	21	NADH	NADH	NNP
cord-018764-02l423mk	156	22	and	and	CC
cord-018764-02l423mk	156	23	FADH2	FADH2	NNP
cord-018764-02l423mk	156	24	)	)	-RRB-
cord-018764-02l423mk	156	25	to	to	TO
cord-018764-02l423mk	156	26	generate	generate	VB
cord-018764-02l423mk	156	27	ATP	ATP	NNP
cord-018764-02l423mk	156	28	.	.	.
cord-018764-02l423mk	157	1	When	when	WRB
cord-018764-02l423mk	157	2	this	this	DT
cord-018764-02l423mk	157	3	series	series	NN
cord-018764-02l423mk	157	4	of	of	IN
cord-018764-02l423mk	157	5	reactions	reaction	NNS
cord-018764-02l423mk	157	6	are	be	VBP
cord-018764-02l423mk	157	7	100	100	CD
cord-018764-02l423mk	157	8	%	%	NN
cord-018764-02l423mk	157	9	efficient	efficient	JJ
cord-018764-02l423mk	157	10	(	(	-LRB-
cord-018764-02l423mk	157	11	unlikely	unlikely	JJ
cord-018764-02l423mk	157	12	in	in	IN
cord-018764-02l423mk	157	13	vivo	vivo	NNP
cord-018764-02l423mk	157	14	)	)	-RRB-
cord-018764-02l423mk	157	15	,	,	,
cord-018764-02l423mk	157	16	1	1	CD
cord-018764-02l423mk	157	17	molecule	molecule	NN
cord-018764-02l423mk	157	18	of	of	IN
cord-018764-02l423mk	157	19	glucose	glucose	NN
cord-018764-02l423mk	157	20	generates	generate	VBZ
cord-018764-02l423mk	157	21	2	2	CD
cord-018764-02l423mk	157	22	molecules	molecule	NNS
cord-018764-02l423mk	157	23	of	of	IN
cord-018764-02l423mk	157	24	pyruvate	pyruvate	NN
cord-018764-02l423mk	157	25	,	,	,
cord-018764-02l423mk	157	26	which	which	WDT
cord-018764-02l423mk	157	27	are	be	VBP
cord-018764-02l423mk	157	28	further	further	RB
cord-018764-02l423mk	157	29	catabolised	catabolise	VBN
cord-018764-02l423mk	157	30	to	to	IN
cord-018764-02l423mk	157	31	water	water	NN
cord-018764-02l423mk	157	32	and	and	CC
cord-018764-02l423mk	157	33	carbon	carbon	NN
cord-018764-02l423mk	157	34	dioxide	dioxide	NN
cord-018764-02l423mk	157	35	with	with	IN
cord-018764-02l423mk	157	36	the	the	DT
cord-018764-02l423mk	157	37	concomitant	concomitant	JJ
cord-018764-02l423mk	157	38	generation	generation	NN
cord-018764-02l423mk	157	39	of	of	IN
cord-018764-02l423mk	157	40	36	36	CD
cord-018764-02l423mk	157	41	molecules	molecule	NNS
cord-018764-02l423mk	157	42	of	of	IN
cord-018764-02l423mk	157	43	ATP	ATP	NNP
cord-018764-02l423mk	157	44	.	.	.
cord-018764-02l423mk	158	1	In	in	IN
cord-018764-02l423mk	158	2	comparison	comparison	NN
cord-018764-02l423mk	158	3	,	,	,
cord-018764-02l423mk	158	4	during	during	IN
cord-018764-02l423mk	158	5	anaerobic	anaerobic	JJ
cord-018764-02l423mk	158	6	glucose	glucose	NN
cord-018764-02l423mk	158	7	catabolism	catabolism	NN
cord-018764-02l423mk	158	8	,	,	,
cord-018764-02l423mk	158	9	pyruvate	pyruvate	NN
cord-018764-02l423mk	158	10	is	be	VBZ
cord-018764-02l423mk	158	11	converted	convert	VBN
cord-018764-02l423mk	158	12	to	to	IN
cord-018764-02l423mk	158	13	lactate	lactate	VB
cord-018764-02l423mk	158	14	with	with	IN
cord-018764-02l423mk	158	15	the	the	DT
cord-018764-02l423mk	158	16	concomitant	concomitant	JJ
cord-018764-02l423mk	158	17	generation	generation	NN
cord-018764-02l423mk	158	18	of	of	IN
cord-018764-02l423mk	158	19	2	2	CD
cord-018764-02l423mk	158	20	molecules	molecule	NNS
cord-018764-02l423mk	158	21	of	of	IN
cord-018764-02l423mk	158	22	ATP	ATP	NNP
cord-018764-02l423mk	158	23	,	,	,
cord-018764-02l423mk	158	24	a	a	DT
cord-018764-02l423mk	158	25	process	process	NN
cord-018764-02l423mk	158	26	that	that	WDT
cord-018764-02l423mk	158	27	also	also	RB
cord-018764-02l423mk	158	28	facilitates	facilitate	VBZ
cord-018764-02l423mk	158	29	regeneration	regeneration	NN
cord-018764-02l423mk	158	30	of	of	IN
cord-018764-02l423mk	158	31	NADH	NADH	NNP
cord-018764-02l423mk	158	32	and	and	CC
cord-018764-02l423mk	158	33	FADH2	FADH2	NNP
cord-018764-02l423mk	158	34	.	.	.
cord-018764-02l423mk	159	1	Evidence	evidence	NN
cord-018764-02l423mk	159	2	is	be	VBZ
cord-018764-02l423mk	159	3	accumulating	accumulate	VBG
cord-018764-02l423mk	159	4	that	that	IN
cord-018764-02l423mk	159	5	inflammatory	inflammatory	JJ
cord-018764-02l423mk	159	6	cytokines	cytokine	NNS
cord-018764-02l423mk	159	7	,	,	,
cord-018764-02l423mk	159	8	as	as	IN
cord-018764-02l423mk	159	9	released	release	VBN
cord-018764-02l423mk	159	10	in	in	IN
cord-018764-02l423mk	159	11	malaria	malaria	NN
cord-018764-02l423mk	159	12	,	,	,
cord-018764-02l423mk	159	13	sepsis	sepsis	NN
cord-018764-02l423mk	159	14	,	,	,
cord-018764-02l423mk	159	15	and	and	CC
cord-018764-02l423mk	159	16	viral	viral	JJ
cord-018764-02l423mk	159	17	diseases	disease	NNS
cord-018764-02l423mk	159	18	,	,	,
cord-018764-02l423mk	159	19	induce	induce	VBP
cord-018764-02l423mk	159	20	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	159	21	dysfunction	dysfunction	NN
cord-018764-02l423mk	159	22	and	and	CC
cord-018764-02l423mk	159	23	dysregulate	dysregulate	VBP
cord-018764-02l423mk	159	24	cellular	cellular	JJ
cord-018764-02l423mk	159	25	respiration	respiration	NN
cord-018764-02l423mk	159	26	,	,	,
cord-018764-02l423mk	159	27	resulting	result	VBG
cord-018764-02l423mk	159	28	in	in	IN
cord-018764-02l423mk	159	29	the	the	DT
cord-018764-02l423mk	159	30	incomplete	incomplete	JJ
cord-018764-02l423mk	159	31	catabolism	catabolism	NN
cord-018764-02l423mk	159	32	of	of	IN
cord-018764-02l423mk	159	33	pyruvate	pyruvate	NN
cord-018764-02l423mk	159	34	.	.	.
cord-018764-02l423mk	160	1	The	the	DT
cord-018764-02l423mk	160	2	process	process	NN
cord-018764-02l423mk	160	3	,	,	,
cord-018764-02l423mk	160	4	termed	term	VBD
cord-018764-02l423mk	160	5	'	'	``
cord-018764-02l423mk	160	6	cytopathic	cytopathic	JJ
cord-018764-02l423mk	160	7	hypoxia	hypoxia	NN
cord-018764-02l423mk	160	8	'	'	''
cord-018764-02l423mk	160	9	[	[	-LRB-
cord-018764-02l423mk	160	10	97	97	CD
cord-018764-02l423mk	160	11	]	]	-RRB-
cord-018764-02l423mk	160	12	,	,	,
cord-018764-02l423mk	160	13	mimics	mimic	VBZ
cord-018764-02l423mk	160	14	cellular	cellular	JJ
cord-018764-02l423mk	160	15	hypoxia	hypoxia	NN
cord-018764-02l423mk	160	16	,	,	,
cord-018764-02l423mk	160	17	in	in	IN
cord-018764-02l423mk	160	18	that	that	IN
cord-018764-02l423mk	160	19	it	-PRON-	PRP
cord-018764-02l423mk	160	20	results	result	VBZ
cord-018764-02l423mk	160	21	in	in	IN
cord-018764-02l423mk	160	22	the	the	DT
cord-018764-02l423mk	160	23	incomplete	incomplete	JJ
cord-018764-02l423mk	160	24	catabolism	catabolism	NN
cord-018764-02l423mk	160	25	of	of	IN
cord-018764-02l423mk	160	26	pyruvate	pyruvate	NN
cord-018764-02l423mk	160	27	and	and	CC
cord-018764-02l423mk	160	28	accumulation	accumulation	NN
cord-018764-02l423mk	160	29	of	of	IN
cord-018764-02l423mk	160	30	lactate	lactate	NN
cord-018764-02l423mk	160	31	.	.	.
cord-018764-02l423mk	161	1	Awareness	awareness	NN
cord-018764-02l423mk	161	2	of	of	IN
cord-018764-02l423mk	161	3	this	this	DT
cord-018764-02l423mk	161	4	mechanism	mechanism	NN
cord-018764-02l423mk	161	5	began	begin	VBD
cord-018764-02l423mk	161	6	with	with	IN
cord-018764-02l423mk	161	7	oxygen	oxygen	NN
cord-018764-02l423mk	161	8	tension	tension	NN
cord-018764-02l423mk	161	9	being	be	VBG
cord-018764-02l423mk	161	10	shown	show	VBN
cord-018764-02l423mk	161	11	to	to	TO
cord-018764-02l423mk	161	12	be	be	VB
cord-018764-02l423mk	161	13	increased	increase	VBN
cord-018764-02l423mk	161	14	in	in	IN
cord-018764-02l423mk	161	15	septic	septic	JJ
cord-018764-02l423mk	161	16	rats	rat	NNS
cord-018764-02l423mk	161	17	[	[	-LRB-
cord-018764-02l423mk	161	18	98	98	CD
cord-018764-02l423mk	161	19	]	]	-RRB-
cord-018764-02l423mk	161	20	and	and	CC
cord-018764-02l423mk	161	21	patients	patient	NNS
cord-018764-02l423mk	161	22	[	[	-LRB-
cord-018764-02l423mk	161	23	99	99	CD
cord-018764-02l423mk	161	24	]	]	-RRB-
cord-018764-02l423mk	161	25	.	.	.
cord-018764-02l423mk	162	1	A	a	DT
cord-018764-02l423mk	162	2	cytokine	cytokine	NN
cord-018764-02l423mk	162	3	model	model	NN
cord-018764-02l423mk	162	4	of	of	IN
cord-018764-02l423mk	162	5	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	162	6	dysfunction	dysfunction	NN
cord-018764-02l423mk	162	7	has	have	VBZ
cord-018764-02l423mk	162	8	since	since	IN
cord-018764-02l423mk	162	9	been	be	VBN
cord-018764-02l423mk	162	10	developed	develop	VBN
cord-018764-02l423mk	162	11	in	in	IN
cord-018764-02l423mk	162	12	which	which	WDT
cord-018764-02l423mk	162	13	impairment	impairment	NN
cord-018764-02l423mk	162	14	of	of	IN
cord-018764-02l423mk	162	15	cellular	cellular	JJ
cord-018764-02l423mk	162	16	respiration	respiration	NN
cord-018764-02l423mk	162	17	occurs	occur	VBZ
cord-018764-02l423mk	162	18	following	follow	VBG
cord-018764-02l423mk	162	19	induction	induction	NN
cord-018764-02l423mk	162	20	of	of	IN
cord-018764-02l423mk	162	21	sepsis	sepsis	NN
cord-018764-02l423mk	162	22	(	(	-LRB-
cord-018764-02l423mk	162	23	or	or	CC
cord-018764-02l423mk	162	24	exposure	exposure	NN
cord-018764-02l423mk	162	25	to	to	IN
cord-018764-02l423mk	162	26	pro	pro	JJ
cord-018764-02l423mk	162	27	-	-	JJ
cord-018764-02l423mk	162	28	inflammatory	inflammatory	JJ
cord-018764-02l423mk	162	29	cytokines	cytokine	NNS
cord-018764-02l423mk	162	30	)	)	-RRB-
cord-018764-02l423mk	162	31	,	,	,
cord-018764-02l423mk	162	32	despite	despite	IN
cord-018764-02l423mk	162	33	sufficient	sufficient	JJ
cord-018764-02l423mk	162	34	oxygen	oxygen	NN
cord-018764-02l423mk	162	35	supply	supply	NN
cord-018764-02l423mk	162	36	[	[	-LRB-
cord-018764-02l423mk	162	37	97	97	CD
cord-018764-02l423mk	162	38	,	,	,
cord-018764-02l423mk	162	39	100	100	CD
cord-018764-02l423mk	162	40	,	,	,
cord-018764-02l423mk	162	41	101	101	CD
cord-018764-02l423mk	162	42	]	]	-RRB-
cord-018764-02l423mk	162	43	.	.	.
cord-018764-02l423mk	163	1	More	more	RBR
cord-018764-02l423mk	163	2	recently	recently	RB
cord-018764-02l423mk	163	3	,	,	,
cord-018764-02l423mk	163	4	impairment	impairment	NN
cord-018764-02l423mk	163	5	of	of	IN
cord-018764-02l423mk	163	6	enzyme	enzyme	NN
cord-018764-02l423mk	163	7	activity	activity	NN
cord-018764-02l423mk	163	8	associated	associate	VBN
cord-018764-02l423mk	163	9	with	with	IN
cord-018764-02l423mk	163	10	the	the	DT
cord-018764-02l423mk	163	11	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	163	12	complexes	complex	NNS
cord-018764-02l423mk	163	13	has	have	VBZ
cord-018764-02l423mk	163	14	been	be	VBN
cord-018764-02l423mk	163	15	demonstrated	demonstrate	VBN
cord-018764-02l423mk	163	16	in	in	IN
cord-018764-02l423mk	163	17	muscle	muscle	NN
cord-018764-02l423mk	163	18	biopsies	biopsy	NNS
cord-018764-02l423mk	163	19	retrieved	retrieve	VBN
cord-018764-02l423mk	163	20	from	from	IN
cord-018764-02l423mk	163	21	rodent	rodent	NN
cord-018764-02l423mk	163	22	models	model	NNS
cord-018764-02l423mk	163	23	of	of	IN
cord-018764-02l423mk	163	24	sepsis	sepsis	NN
cord-018764-02l423mk	163	25	[	[	-LRB-
cord-018764-02l423mk	163	26	102	102	CD
cord-018764-02l423mk	163	27	]	]	-RRB-
cord-018764-02l423mk	163	28	and	and	CC
cord-018764-02l423mk	163	29	septic	septic	JJ
cord-018764-02l423mk	163	30	patients	patient	NNS
cord-018764-02l423mk	163	31	[	[	-LRB-
cord-018764-02l423mk	163	32	103	103	CD
cord-018764-02l423mk	163	33	,	,	,
cord-018764-02l423mk	163	34	104	104	CD
cord-018764-02l423mk	163	35	]	]	-RRB-
cord-018764-02l423mk	163	36	.	.	.
cord-018764-02l423mk	164	1	The	the	DT
cord-018764-02l423mk	164	2	observation	observation	NN
cord-018764-02l423mk	164	3	that	that	IN
cord-018764-02l423mk	164	4	the	the	DT
cord-018764-02l423mk	164	5	inflammatory	inflammatory	JJ
cord-018764-02l423mk	164	6	cytokines	cytokine	NNS
cord-018764-02l423mk	164	7	implicated	implicate	VBN
cord-018764-02l423mk	164	8	in	in	IN
cord-018764-02l423mk	164	9	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	164	10	shutdown	shutdown	NN
cord-018764-02l423mk	164	11	are	be	VBP
cord-018764-02l423mk	164	12	prominent	prominent	JJ
cord-018764-02l423mk	164	13	in	in	IN
cord-018764-02l423mk	164	14	both	both	CC
cord-018764-02l423mk	164	15	sepsis	sepsis	NN
cord-018764-02l423mk	164	16	and	and	CC
cord-018764-02l423mk	164	17	malaria	malaria	NN
cord-018764-02l423mk	164	18	[	[	-LRB-
cord-018764-02l423mk	164	19	105	105	CD
cord-018764-02l423mk	164	20	,	,	,
cord-018764-02l423mk	164	21	106	106	CD
cord-018764-02l423mk	164	22	]	]	-RRB-
cord-018764-02l423mk	164	23	supports	support	VBZ
cord-018764-02l423mk	164	24	such	such	JJ
cord-018764-02l423mk	164	25	organelle	organelle	NN
cord-018764-02l423mk	164	26	dysfunction	dysfunction	NN
cord-018764-02l423mk	164	27	being	be	VBG
cord-018764-02l423mk	164	28	equally	equally	RB
cord-018764-02l423mk	164	29	plausible	plausible	JJ
cord-018764-02l423mk	164	30	in	in	IN
cord-018764-02l423mk	164	31	malaria	malaria	NN
cord-018764-02l423mk	164	32	.	.	.
cord-018764-02l423mk	165	1	Researchers	researcher	NNS
cord-018764-02l423mk	165	2	are	be	VBP
cord-018764-02l423mk	165	3	also	also	RB
cord-018764-02l423mk	165	4	becoming	become	VBG
cord-018764-02l423mk	165	5	aware	aware	JJ
cord-018764-02l423mk	165	6	that	that	IN
cord-018764-02l423mk	165	7	,	,	,
cord-018764-02l423mk	165	8	beyond	beyond	IN
cord-018764-02l423mk	165	9	energy	energy	NN
cord-018764-02l423mk	165	10	production	production	NN
cord-018764-02l423mk	165	11	,	,	,
cord-018764-02l423mk	165	12	mitochondria	mitochondrion	NNS
cord-018764-02l423mk	165	13	also	also	RB
cord-018764-02l423mk	165	14	play	play	VBP
cord-018764-02l423mk	165	15	a	a	DT
cord-018764-02l423mk	165	16	vital	vital	JJ
cord-018764-02l423mk	165	17	role	role	NN
cord-018764-02l423mk	165	18	in	in	IN
cord-018764-02l423mk	165	19	cell	cell	NN
cord-018764-02l423mk	165	20	homeostasis	homeostasis	NN
cord-018764-02l423mk	165	21	through	through	IN
cord-018764-02l423mk	165	22	generation	generation	NN
cord-018764-02l423mk	165	23	and	and	CC
cord-018764-02l423mk	165	24	detoxification	detoxification	NN
cord-018764-02l423mk	165	25	of	of	IN
cord-018764-02l423mk	165	26	reactive	reactive	JJ
cord-018764-02l423mk	165	27	oxygen	oxygen	NN
cord-018764-02l423mk	165	28	species	specie	NNS
cord-018764-02l423mk	165	29	[	[	-LRB-
cord-018764-02l423mk	165	30	107	107	CD
cord-018764-02l423mk	165	31	]	]	-RRB-
cord-018764-02l423mk	165	32	.	.	.
cord-018764-02l423mk	166	1	The	the	DT
cord-018764-02l423mk	166	2	accelerated	accelerated	JJ
cord-018764-02l423mk	166	3	oxidative	oxidative	JJ
cord-018764-02l423mk	166	4	damage	damage	NN
cord-018764-02l423mk	166	5	that	that	WDT
cord-018764-02l423mk	166	6	accompanies	accompany	VBZ
cord-018764-02l423mk	166	7	sepsis	sepsis	NN
cord-018764-02l423mk	166	8	could	could	MD
cord-018764-02l423mk	166	9	be	be	VB
cord-018764-02l423mk	166	10	both	both	CC
cord-018764-02l423mk	166	11	a	a	DT
cord-018764-02l423mk	166	12	cause	cause	NN
cord-018764-02l423mk	166	13	and	and	CC
cord-018764-02l423mk	166	14	a	a	DT
cord-018764-02l423mk	166	15	consequence	consequence	NN
cord-018764-02l423mk	166	16	of	of	IN
cord-018764-02l423mk	166	17	cytokine	cytokine	NN
cord-018764-02l423mk	166	18	-	-	HYPH
cord-018764-02l423mk	166	19	induced	induce	VBN
cord-018764-02l423mk	166	20	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	166	21	dysfunction	dysfunction	NN
cord-018764-02l423mk	166	22	.	.	.
cord-018764-02l423mk	167	1	Interestingly	interestingly	RB
cord-018764-02l423mk	167	2	,	,	,
cord-018764-02l423mk	167	3	the	the	DT
cord-018764-02l423mk	167	4	ultrastructural	ultrastructural	JJ
cord-018764-02l423mk	167	5	damage	damage	NN
cord-018764-02l423mk	167	6	reported	report	VBN
cord-018764-02l423mk	167	7	to	to	TO
cord-018764-02l423mk	167	8	accompany	accompany	VB
cord-018764-02l423mk	167	9	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	167	10	dysfunction	dysfunction	NN
cord-018764-02l423mk	167	11	in	in	IN
cord-018764-02l423mk	167	12	sepsis	sepsis	NN
cord-018764-02l423mk	167	13	[	[	-LRB-
cord-018764-02l423mk	167	14	102	102	CD
cord-018764-02l423mk	167	15	]	]	-RRB-
cord-018764-02l423mk	167	16	reflects	reflect	VBZ
cord-018764-02l423mk	167	17	Maegraith	Maegraith	NNP
cord-018764-02l423mk	167	18	's	's	POS
cord-018764-02l423mk	167	19	observations	observation	NNS
cord-018764-02l423mk	167	20	in	in	IN
cord-018764-02l423mk	167	21	monkey	monkey	NN
cord-018764-02l423mk	167	22	malaria	malaria	NN
cord-018764-02l423mk	167	23	[	[	-LRB-
cord-018764-02l423mk	167	24	108	108	CD
cord-018764-02l423mk	167	25	]	]	-RRB-
cord-018764-02l423mk	167	26	[	[	-LRB-
cord-018764-02l423mk	167	27	109	109	CD
cord-018764-02l423mk	167	28	]	]	-RRB-
cord-018764-02l423mk	167	29	[	[	-LRB-
cord-018764-02l423mk	167	30	110	110	CD
cord-018764-02l423mk	167	31	]	]	-RRB-
cord-018764-02l423mk	167	32	decades	decade	NNS
cord-018764-02l423mk	167	33	ago	ago	RB
cord-018764-02l423mk	167	34	.	.	.
cord-018764-02l423mk	168	1	Metabolic	metabolic	JJ
cord-018764-02l423mk	168	2	acidosis	acidosis	NN
cord-018764-02l423mk	168	3	,	,	,
cord-018764-02l423mk	168	4	often	often	RB
cord-018764-02l423mk	168	5	associated	associate	VBN
cord-018764-02l423mk	168	6	with	with	IN
cord-018764-02l423mk	168	7	hyperlactataemia	hyperlactataemia	NN
cord-018764-02l423mk	168	8	,	,	,
cord-018764-02l423mk	168	9	has	have	VBZ
cord-018764-02l423mk	168	10	been	be	VBN
cord-018764-02l423mk	168	11	described	describe	VBN
cord-018764-02l423mk	168	12	in	in	IN
cord-018764-02l423mk	168	13	African	african	JJ
cord-018764-02l423mk	168	14	children	child	NNS
cord-018764-02l423mk	168	15	with	with	IN
cord-018764-02l423mk	168	16	severe	severe	JJ
cord-018764-02l423mk	168	17	falciparum	falciparum	NN
cord-018764-02l423mk	168	18	malaria	malaria	NN
cord-018764-02l423mk	168	19	[	[	-LRB-
cord-018764-02l423mk	168	20	111	111	CD
cord-018764-02l423mk	168	21	,	,	,
cord-018764-02l423mk	168	22	112	112	CD
cord-018764-02l423mk	168	23	]	]	-RRB-
cord-018764-02l423mk	168	24	.	.	.
cord-018764-02l423mk	169	1	It	-PRON-	PRP
cord-018764-02l423mk	169	2	is	be	VBZ
cord-018764-02l423mk	169	3	not	not	RB
cord-018764-02l423mk	169	4	unique	unique	JJ
cord-018764-02l423mk	169	5	to	to	IN
cord-018764-02l423mk	169	6	this	this	DT
cord-018764-02l423mk	169	7	disease	disease	NN
cord-018764-02l423mk	169	8	,	,	,
cord-018764-02l423mk	169	9	being	be	VBG
cord-018764-02l423mk	169	10	seen	see	VBN
cord-018764-02l423mk	169	11	in	in	IN
cord-018764-02l423mk	169	12	viral	viral	JJ
cord-018764-02l423mk	169	13	,	,	,
cord-018764-02l423mk	169	14	rickettsial	rickettsial	JJ
cord-018764-02l423mk	169	15	and	and	CC
cord-018764-02l423mk	169	16	bacterial	bacterial	JJ
cord-018764-02l423mk	169	17	infections	infection	NNS
cord-018764-02l423mk	169	18	[	[	-LRB-
cord-018764-02l423mk	169	19	113	113	CD
cord-018764-02l423mk	169	20	]	]	-RRB-
cord-018764-02l423mk	169	21	as	as	RB
cord-018764-02l423mk	169	22	well	well	RB
cord-018764-02l423mk	169	23	as	as	IN
cord-018764-02l423mk	169	24	acute	acute	JJ
cord-018764-02l423mk	169	25	gastroenteritis	gastroenteritis	NN
cord-018764-02l423mk	169	26	,	,	,
cord-018764-02l423mk	169	27	where	where	WRB
cord-018764-02l423mk	169	28	its	-PRON-	PRP$
cord-018764-02l423mk	169	29	prevalence	prevalence	NN
cord-018764-02l423mk	169	30	is	be	VBZ
cord-018764-02l423mk	169	31	higher	high	JJR
cord-018764-02l423mk	169	32	than	than	IN
cord-018764-02l423mk	169	33	in	in	IN
cord-018764-02l423mk	169	34	malaria	malaria	NN
cord-018764-02l423mk	169	35	[	[	-LRB-
cord-018764-02l423mk	169	36	114	114	CD
cord-018764-02l423mk	169	37	]	]	-RRB-
cord-018764-02l423mk	169	38	.	.	.
cord-018764-02l423mk	170	1	The	the	DT
cord-018764-02l423mk	170	2	terms	term	NNS
cord-018764-02l423mk	170	3	hyperlactataemia	hyperlactataemia	NN
cord-018764-02l423mk	170	4	and	and	CC
cord-018764-02l423mk	170	5	lactic	lactic	JJ
cord-018764-02l423mk	170	6	acidosis	acidosis	NN
cord-018764-02l423mk	170	7	are	be	VBP
cord-018764-02l423mk	170	8	often	often	RB
cord-018764-02l423mk	170	9	mistakenly	mistakenly	RB
cord-018764-02l423mk	170	10	used	use	VBN
cord-018764-02l423mk	170	11	interchangeably	interchangeably	RB
cord-018764-02l423mk	170	12	in	in	IN
cord-018764-02l423mk	170	13	the	the	DT
cord-018764-02l423mk	170	14	malaria	malaria	NN
cord-018764-02l423mk	170	15	literature	literature	NN
cord-018764-02l423mk	170	16	.	.	.
cord-018764-02l423mk	171	1	As	as	RB
cord-018764-02l423mk	171	2	often	often	RB
cord-018764-02l423mk	171	3	reviewed	review	VBN
cord-018764-02l423mk	171	4	in	in	IN
cord-018764-02l423mk	171	5	the	the	DT
cord-018764-02l423mk	171	6	basic	basic	JJ
cord-018764-02l423mk	171	7	literature	literature	NN
cord-018764-02l423mk	171	8	[	[	-LRB-
cord-018764-02l423mk	171	9	115	115	CD
cord-018764-02l423mk	171	10	]	]	-RRB-
cord-018764-02l423mk	171	11	[	[	-LRB-
cord-018764-02l423mk	171	12	116	116	CD
cord-018764-02l423mk	171	13	]	]	-RRB-
cord-018764-02l423mk	171	14	[	[	-LRB-
cord-018764-02l423mk	171	15	117	117	CD
cord-018764-02l423mk	171	16	]	]	-RRB-
cord-018764-02l423mk	171	17	[	[	-LRB-
cord-018764-02l423mk	171	18	118	118	CD
cord-018764-02l423mk	171	19	]	]	-RRB-
cord-018764-02l423mk	171	20	,	,	,
cord-018764-02l423mk	171	21	protons	proton	NNS
cord-018764-02l423mk	171	22	(	(	-LRB-
cord-018764-02l423mk	171	23	H	H	NNP
cord-018764-02l423mk	171	24	+	+	CC
cord-018764-02l423mk	171	25	,	,	,
cord-018764-02l423mk	171	26	the	the	DT
cord-018764-02l423mk	171	27	basis	basis	NN
cord-018764-02l423mk	171	28	of	of	IN
cord-018764-02l423mk	171	29	acidosis	acidosis	NN
cord-018764-02l423mk	171	30	)	)	-RRB-
cord-018764-02l423mk	171	31	are	be	VBP
cord-018764-02l423mk	171	32	not	not	RB
cord-018764-02l423mk	171	33	formed	form	VBN
cord-018764-02l423mk	171	34	when	when	WRB
cord-018764-02l423mk	171	35	ATP	ATP	NNP
cord-018764-02l423mk	171	36	and	and	CC
cord-018764-02l423mk	171	37	lactate	lactate	NN
cord-018764-02l423mk	171	38	are	be	VBP
cord-018764-02l423mk	171	39	generated	generate	VBN
cord-018764-02l423mk	171	40	during	during	IN
cord-018764-02l423mk	171	41	glycolysis	glycolysis	NN
cord-018764-02l423mk	171	42	,	,	,
cord-018764-02l423mk	171	43	but	but	CC
cord-018764-02l423mk	171	44	on	on	IN
cord-018764-02l423mk	171	45	the	the	DT
cord-018764-02l423mk	171	46	subsequent	subsequent	JJ
cord-018764-02l423mk	171	47	hydrolysis	hydrolysis	NN
cord-018764-02l423mk	171	48	of	of	IN
cord-018764-02l423mk	171	49	ATP	ATP	NNP
cord-018764-02l423mk	171	50	in	in	IN
cord-018764-02l423mk	171	51	tissues	tissue	NNS
cord-018764-02l423mk	171	52	.	.	.
cord-018764-02l423mk	172	1	Every	every	DT
cord-018764-02l423mk	172	2	time	time	NN
cord-018764-02l423mk	172	3	a	a	DT
cord-018764-02l423mk	172	4	molecule	molecule	NN
cord-018764-02l423mk	172	5	of	of	IN
cord-018764-02l423mk	172	6	ATP	ATP	NNP
cord-018764-02l423mk	172	7	undergoes	undergo	VBZ
cord-018764-02l423mk	172	8	hydrolysis	hydrolysis	NN
cord-018764-02l423mk	172	9	,	,	,
cord-018764-02l423mk	172	10	a	a	DT
cord-018764-02l423mk	172	11	proton	proton	NN
cord-018764-02l423mk	172	12	is	be	VBZ
cord-018764-02l423mk	172	13	released	release	VBN
cord-018764-02l423mk	172	14	.	.	.
cord-018764-02l423mk	173	1	If	if	IN
cord-018764-02l423mk	173	2	this	this	DT
cord-018764-02l423mk	173	3	occurs	occur	VBZ
cord-018764-02l423mk	173	4	under	under	IN
cord-018764-02l423mk	173	5	aero	aero	NNP
cord-018764-02l423mk	173	6	-	-	HYPH
cord-018764-02l423mk	173	7	bic	bic	JJ
cord-018764-02l423mk	173	8	conditions	condition	NNS
cord-018764-02l423mk	173	9	,	,	,
cord-018764-02l423mk	173	10	these	these	DT
cord-018764-02l423mk	173	11	protons	proton	NNS
cord-018764-02l423mk	173	12	are	be	VBP
cord-018764-02l423mk	173	13	consumed	consume	VBN
cord-018764-02l423mk	173	14	within	within	IN
cord-018764-02l423mk	173	15	ATP	ATP	NNP
cord-018764-02l423mk	173	16	regeneration	regeneration	NN
cord-018764-02l423mk	173	17	from	from	IN
cord-018764-02l423mk	173	18	ADP	ADP	NNP
cord-018764-02l423mk	173	19	,	,	,
cord-018764-02l423mk	173	20	and	and	CC
cord-018764-02l423mk	173	21	pH	pH	NNP
cord-018764-02l423mk	173	22	remains	remain	VBZ
cord-018764-02l423mk	173	23	normal	normal	JJ
cord-018764-02l423mk	173	24	,	,	,
cord-018764-02l423mk	173	25	i.e.	i.e.	FW
cord-018764-02l423mk	173	26	acidosis	acidosis	NN
cord-018764-02l423mk	173	27	does	do	VBZ
cord-018764-02l423mk	173	28	not	not	RB
cord-018764-02l423mk	173	29	occur	occur	VB
cord-018764-02l423mk	173	30	.	.	.
cord-018764-02l423mk	174	1	In	in	IN
cord-018764-02l423mk	174	2	contrast	contrast	NN
cord-018764-02l423mk	174	3	,	,	,
cord-018764-02l423mk	174	4	if	if	IN
cord-018764-02l423mk	174	5	the	the	DT
cord-018764-02l423mk	174	6	mitochondria	mitochondrion	NNS
cord-018764-02l423mk	174	7	are	be	VBP
cord-018764-02l423mk	174	8	not	not	RB
cord-018764-02l423mk	174	9	functioning	function	VBG
cord-018764-02l423mk	174	10	adequately	adequately	RB
cord-018764-02l423mk	174	11	,	,	,
cord-018764-02l423mk	174	12	whether	whether	IN
cord-018764-02l423mk	174	13	through	through	IN
cord-018764-02l423mk	174	14	insufficient	insufficient	JJ
cord-018764-02l423mk	174	15	oxygen	oxygen	NN
cord-018764-02l423mk	174	16	supply	supply	NN
cord-018764-02l423mk	174	17	or	or	CC
cord-018764-02l423mk	174	18	an	an	DT
cord-018764-02l423mk	174	19	inability	inability	NN
cord-018764-02l423mk	174	20	to	to	TO
cord-018764-02l423mk	174	21	use	use	VB
cord-018764-02l423mk	174	22	it	-PRON-	PRP
cord-018764-02l423mk	174	23	,	,	,
cord-018764-02l423mk	174	24	ATP	ATP	NNP
cord-018764-02l423mk	174	25	regenerates	regenerate	VBZ
cord-018764-02l423mk	174	26	under	under	IN
cord-018764-02l423mk	174	27	anaerobic	anaerobic	JJ
cord-018764-02l423mk	174	28	condition	condition	NN
cord-018764-02l423mk	174	29	,	,	,
cord-018764-02l423mk	174	30	and	and	CC
cord-018764-02l423mk	174	31	the	the	DT
cord-018764-02l423mk	174	32	protons	proton	NNS
cord-018764-02l423mk	174	33	are	be	VBP
cord-018764-02l423mk	174	34	not	not	RB
cord-018764-02l423mk	174	35	consumed	consume	VBN
cord-018764-02l423mk	174	36	.	.	.
cord-018764-02l423mk	175	1	Hence	hence	RB
cord-018764-02l423mk	175	2	,	,	,
cord-018764-02l423mk	175	3	once	once	IN
cord-018764-02l423mk	175	4	the	the	DT
cord-018764-02l423mk	175	5	buffering	buffering	NN
cord-018764-02l423mk	175	6	capacity	capacity	NN
cord-018764-02l423mk	175	7	of	of	IN
cord-018764-02l423mk	175	8	the	the	DT
cord-018764-02l423mk	175	9	body	body	NN
cord-018764-02l423mk	175	10	is	be	VBZ
cord-018764-02l423mk	175	11	exceeded	exceed	VBN
cord-018764-02l423mk	175	12	,	,	,
cord-018764-02l423mk	175	13	acidosis	acidosis	NN
cord-018764-02l423mk	175	14	occurs	occur	VBZ
cord-018764-02l423mk	175	15	.	.	.
cord-018764-02l423mk	176	1	In	in	IN
cord-018764-02l423mk	176	2	short	short	JJ
cord-018764-02l423mk	176	3	,	,	,
cord-018764-02l423mk	176	4	metabolic	metabolic	JJ
cord-018764-02l423mk	176	5	acidosis	acidosis	NN
cord-018764-02l423mk	176	6	requires	require	VBZ
cord-018764-02l423mk	176	7	the	the	DT
cord-018764-02l423mk	176	8	ratio	ratio	NN
cord-018764-02l423mk	176	9	of	of	IN
cord-018764-02l423mk	176	10	glycolytic	glycolytic	JJ
cord-018764-02l423mk	176	11	(	(	-LRB-
cord-018764-02l423mk	176	12	i.e.	i.e.	FW
cord-018764-02l423mk	176	13	anaerobic	anaerobic	JJ
cord-018764-02l423mk	176	14	)	)	-RRB-
cord-018764-02l423mk	177	1	ATP	ATP	NNP
cord-018764-02l423mk	177	2	hydrolysis	hydrolysis	NN
cord-018764-02l423mk	177	3	to	to	IN
cord-018764-02l423mk	177	4	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	177	5	(	(	-LRB-
cord-018764-02l423mk	177	6	i.e.	i.e.	FW
cord-018764-02l423mk	177	7	aerobic	aerobic	JJ
cord-018764-02l423mk	177	8	)	)	-RRB-
cord-018764-02l423mk	177	9	ATP	ATP	NNP
cord-018764-02l423mk	177	10	hydrolysis	hydrolysis	NN
cord-018764-02l423mk	178	1	to	to	TO
cord-018764-02l423mk	178	2	reach	reach	VB
cord-018764-02l423mk	178	3	a	a	DT
cord-018764-02l423mk	178	4	point	point	NN
cord-018764-02l423mk	178	5	at	at	IN
cord-018764-02l423mk	178	6	which	which	WDT
cord-018764-02l423mk	178	7	the	the	DT
cord-018764-02l423mk	178	8	buffering	buffer	VBG
cord-018764-02l423mk	178	9	systems	system	NNS
cord-018764-02l423mk	178	10	can	can	MD
cord-018764-02l423mk	178	11	no	no	RB
cord-018764-02l423mk	178	12	longer	longer	RB
cord-018764-02l423mk	178	13	cope	cope	VB
cord-018764-02l423mk	178	14	.	.	.
cord-018764-02l423mk	179	1	Pathological	pathological	JJ
cord-018764-02l423mk	179	2	changes	change	NNS
cord-018764-02l423mk	179	3	in	in	IN
cord-018764-02l423mk	179	4	the	the	DT
cord-018764-02l423mk	179	5	buffering	buffering	NN
cord-018764-02l423mk	179	6	system	system	NN
cord-018764-02l423mk	179	7	can	can	MD
cord-018764-02l423mk	179	8	be	be	VB
cord-018764-02l423mk	179	9	a	a	DT
cord-018764-02l423mk	179	10	major	major	JJ
cord-018764-02l423mk	179	11	determinant	determinant	NN
cord-018764-02l423mk	179	12	of	of	IN
cord-018764-02l423mk	179	13	when	when	WRB
cord-018764-02l423mk	179	14	this	this	DT
cord-018764-02l423mk	179	15	occurs	occur	VBZ
cord-018764-02l423mk	179	16	.	.	.
cord-018764-02l423mk	180	1	High	high	JJ
cord-018764-02l423mk	180	2	lactate	lactate	NN
cord-018764-02l423mk	180	3	levels	level	NNS
cord-018764-02l423mk	180	4	have	have	VBP
cord-018764-02l423mk	180	5	traditionally	traditionally	RB
cord-018764-02l423mk	180	6	been	be	VBN
cord-018764-02l423mk	180	7	seen	see	VBN
cord-018764-02l423mk	180	8	not	not	RB
cord-018764-02l423mk	180	9	only	only	RB
cord-018764-02l423mk	180	10	as	as	IN
cord-018764-02l423mk	180	11	a	a	DT
cord-018764-02l423mk	180	12	marker	marker	NN
cord-018764-02l423mk	180	13	for	for	IN
cord-018764-02l423mk	180	14	poor	poor	JJ
cord-018764-02l423mk	180	15	oxygen	oxygen	NN
cord-018764-02l423mk	180	16	delivery	delivery	NN
cord-018764-02l423mk	180	17	in	in	IN
cord-018764-02l423mk	180	18	disease	disease	NN
cord-018764-02l423mk	180	19	states	state	NNS
cord-018764-02l423mk	180	20	,	,	,
cord-018764-02l423mk	180	21	but	but	CC
cord-018764-02l423mk	180	22	also	also	RB
cord-018764-02l423mk	180	23	a	a	DT
cord-018764-02l423mk	180	24	consequence	consequence	NN
cord-018764-02l423mk	180	25	of	of	IN
cord-018764-02l423mk	180	26	it	-PRON-	PRP
cord-018764-02l423mk	180	27	,	,	,
cord-018764-02l423mk	180	28	and	and	CC
cord-018764-02l423mk	180	29	the	the	DT
cord-018764-02l423mk	180	30	cause	cause	NN
cord-018764-02l423mk	180	31	of	of	IN
cord-018764-02l423mk	180	32	the	the	DT
cord-018764-02l423mk	180	33	acidosis	acidosis	NN
cord-018764-02l423mk	180	34	.	.	.
cord-018764-02l423mk	181	1	For	for	IN
cord-018764-02l423mk	181	2	some	some	DT
cord-018764-02l423mk	181	3	time	time	NN
cord-018764-02l423mk	181	4	hyperlactataemia	hyperlactataemia	NN
cord-018764-02l423mk	181	5	has	have	VBZ
cord-018764-02l423mk	181	6	been	be	VBN
cord-018764-02l423mk	181	7	regarded	regard	VBN
cord-018764-02l423mk	181	8	as	as	IN
cord-018764-02l423mk	181	9	a	a	DT
cord-018764-02l423mk	181	10	functionally	functionally	RB
cord-018764-02l423mk	181	11	relevant	relevant	JJ
cord-018764-02l423mk	181	12	marker	marker	NN
cord-018764-02l423mk	181	13	for	for	IN
cord-018764-02l423mk	181	14	a	a	DT
cord-018764-02l423mk	181	15	poor	poor	JJ
cord-018764-02l423mk	181	16	prognosis	prognosis	NN
cord-018764-02l423mk	181	17	in	in	IN
cord-018764-02l423mk	181	18	both	both	DT
cord-018764-02l423mk	181	19	sepsis	sepsis	NN
cord-018764-02l423mk	181	20	[	[	-LRB-
cord-018764-02l423mk	181	21	119	119	CD
cord-018764-02l423mk	181	22	]	]	-RRB-
cord-018764-02l423mk	181	23	and	and	CC
cord-018764-02l423mk	181	24	malaria	malaria	NN
cord-018764-02l423mk	181	25	[	[	-LRB-
cord-018764-02l423mk	181	26	66	66	CD
cord-018764-02l423mk	181	27	,	,	,
cord-018764-02l423mk	181	28	112	112	CD
cord-018764-02l423mk	181	29	,	,	,
cord-018764-02l423mk	181	30	120	120	CD
cord-018764-02l423mk	181	31	]	]	-RRB-
cord-018764-02l423mk	181	32	.	.	.
cord-018764-02l423mk	182	1	Although	although	IN
cord-018764-02l423mk	182	2	the	the	DT
cord-018764-02l423mk	182	3	sepsis	sepsis	NN
cord-018764-02l423mk	182	4	world	world	NN
cord-018764-02l423mk	182	5	now	now	RB
cord-018764-02l423mk	182	6	discusses	discuss	VBZ
cord-018764-02l423mk	182	7	several	several	JJ
cord-018764-02l423mk	182	8	origins	origin	NNS
cord-018764-02l423mk	182	9	for	for	IN
cord-018764-02l423mk	182	10	the	the	DT
cord-018764-02l423mk	182	11	lactate	lactate	NN
cord-018764-02l423mk	182	12	increase	increase	NN
cord-018764-02l423mk	182	13	,	,	,
cord-018764-02l423mk	182	14	including	include	VBG
cord-018764-02l423mk	182	15	inflammation	inflammation	NN
cord-018764-02l423mk	182	16	-	-	HYPH
cord-018764-02l423mk	182	17	induced	induce	VBN
cord-018764-02l423mk	182	18	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	182	19	dysfunction	dysfunction	NN
cord-018764-02l423mk	182	20	[	[	-LRB-
cord-018764-02l423mk	182	21	97	97	CD
cord-018764-02l423mk	182	22	]	]	-RRB-
cord-018764-02l423mk	182	23	,	,	,
cord-018764-02l423mk	182	24	in	in	IN
cord-018764-02l423mk	182	25	falciparum	falciparum	NN
cord-018764-02l423mk	182	26	malaria	malaria	NN
cord-018764-02l423mk	182	27	it	-PRON-	PRP
cord-018764-02l423mk	182	28	is	be	VBZ
cord-018764-02l423mk	182	29	still	still	RB
cord-018764-02l423mk	182	30	generally	generally	RB
cord-018764-02l423mk	182	31	attributed	attribute	VBN
cord-018764-02l423mk	182	32	to	to	IN
cord-018764-02l423mk	182	33	a	a	DT
cord-018764-02l423mk	182	34	reduced	reduce	VBN
cord-018764-02l423mk	182	35	oxygen	oxygen	NN
cord-018764-02l423mk	182	36	supply	supply	NN
cord-018764-02l423mk	182	37	,	,	,
cord-018764-02l423mk	182	38	mostly	mostly	RB
cord-018764-02l423mk	182	39	through	through	IN
cord-018764-02l423mk	182	40	microvascular	microvascular	JJ
cord-018764-02l423mk	182	41	occlusion	occlusion	NN
cord-018764-02l423mk	182	42	by	by	IN
cord-018764-02l423mk	182	43	sequestered	sequester	VBN
cord-018764-02l423mk	182	44	parasitised	parasitised	JJ
cord-018764-02l423mk	182	45	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	182	46	[	[	-LRB-
cord-018764-02l423mk	182	47	121	121	CD
cord-018764-02l423mk	182	48	]	]	-RRB-
cord-018764-02l423mk	182	49	.	.	.
cord-018764-02l423mk	183	1	Other	other	JJ
cord-018764-02l423mk	183	2	mechanisms	mechanism	NNS
cord-018764-02l423mk	183	3	are	be	VBP
cord-018764-02l423mk	183	4	known	know	VBN
cord-018764-02l423mk	183	5	to	to	TO
cord-018764-02l423mk	183	6	contribute	contribute	VB
cord-018764-02l423mk	183	7	to	to	IN
cord-018764-02l423mk	183	8	acidosis	acidosis	NN
cord-018764-02l423mk	183	9	in	in	IN
cord-018764-02l423mk	183	10	malaria	malaria	NN
cord-018764-02l423mk	183	11	,	,	,
cord-018764-02l423mk	183	12	independent	independent	JJ
cord-018764-02l423mk	183	13	of	of	IN
cord-018764-02l423mk	183	14	lactate	lactate	NN
cord-018764-02l423mk	183	15	production	production	NN
cord-018764-02l423mk	183	16	,	,	,
cord-018764-02l423mk	183	17	e.g.	e.g.	RB
cord-018764-02l423mk	183	18	acute	acute	JJ
cord-018764-02l423mk	183	19	renal	renal	JJ
cord-018764-02l423mk	183	20	failure	failure	NN
cord-018764-02l423mk	183	21	[	[	-LRB-
cord-018764-02l423mk	183	22	8	8	CD
cord-018764-02l423mk	183	23	]	]	-RRB-
cord-018764-02l423mk	183	24	.	.	.
cord-018764-02l423mk	184	1	Impaired	impaired	JJ
cord-018764-02l423mk	184	2	hepatic	hepatic	JJ
cord-018764-02l423mk	184	3	clearance	clearance	NN
cord-018764-02l423mk	184	4	[	[	-LRB-
cord-018764-02l423mk	184	5	8	8	CD
cord-018764-02l423mk	184	6	,	,	,
cord-018764-02l423mk	184	7	112	112	CD
cord-018764-02l423mk	184	8	]	]	-RRB-
cord-018764-02l423mk	184	9	,	,	,
cord-018764-02l423mk	184	10	production	production	NN
cord-018764-02l423mk	184	11	by	by	IN
cord-018764-02l423mk	184	12	parasites	parasite	NNS
cord-018764-02l423mk	184	13	,	,	,
cord-018764-02l423mk	184	14	and	and	CC
cord-018764-02l423mk	184	15	,	,	,
cord-018764-02l423mk	185	1	in	in	IN
cord-018764-02l423mk	185	2	some	some	DT
cord-018764-02l423mk	185	3	areas	area	NNS
cord-018764-02l423mk	185	4	,	,	,
cord-018764-02l423mk	185	5	thiamine	thiamine	NN
cord-018764-02l423mk	185	6	deficiency	deficiency	NN
cord-018764-02l423mk	185	7	[	[	-LRB-
cord-018764-02l423mk	185	8	122	122	CD
cord-018764-02l423mk	185	9	]	]	-RRB-
cord-018764-02l423mk	185	10	are	be	VBP
cord-018764-02l423mk	185	11	also	also	RB
cord-018764-02l423mk	185	12	argued	argue	VBN
cord-018764-02l423mk	185	13	to	to	TO
cord-018764-02l423mk	185	14	contribute	contribute	VB
cord-018764-02l423mk	185	15	to	to	IN
cord-018764-02l423mk	185	16	lactate	lactate	NN
cord-018764-02l423mk	185	17	accumulation	accumulation	NN
cord-018764-02l423mk	185	18	independent	independent	JJ
cord-018764-02l423mk	185	19	of	of	IN
cord-018764-02l423mk	185	20	impaired	impaired	JJ
cord-018764-02l423mk	185	21	cellular	cellular	JJ
cord-018764-02l423mk	185	22	respiration	respiration	NN
cord-018764-02l423mk	185	23	.	.	.
cord-018764-02l423mk	186	1	Thus	thus	RB
cord-018764-02l423mk	186	2	,	,	,
cord-018764-02l423mk	186	3	as	as	IN
cord-018764-02l423mk	186	4	described	describe	VBN
cord-018764-02l423mk	186	5	below	below	RB
cord-018764-02l423mk	186	6	,	,	,
cord-018764-02l423mk	186	7	although	although	IN
cord-018764-02l423mk	186	8	acidosis	acidosis	NN
cord-018764-02l423mk	186	9	and	and	CC
cord-018764-02l423mk	186	10	hyperlactataemia	hyperlactataemia	NN
cord-018764-02l423mk	186	11	can	can	MD
cord-018764-02l423mk	186	12	be	be	VB
cord-018764-02l423mk	186	13	associated	associate	VBN
cord-018764-02l423mk	186	14	,	,	,
cord-018764-02l423mk	186	15	they	-PRON-	PRP
cord-018764-02l423mk	186	16	are	be	VBP
cord-018764-02l423mk	186	17	independent	independent	JJ
cord-018764-02l423mk	186	18	cellular	cellular	JJ
cord-018764-02l423mk	186	19	mechanisms	mechanism	NNS
cord-018764-02l423mk	186	20	.	.	.
cord-018764-02l423mk	187	1	Lactate	lactate	NN
cord-018764-02l423mk	187	2	anion	anion	NN
cord-018764-02l423mk	187	3	has	have	VBZ
cord-018764-02l423mk	187	4	complex	complex	JJ
cord-018764-02l423mk	187	5	roles	role	NNS
cord-018764-02l423mk	187	6	in	in	IN
cord-018764-02l423mk	187	7	biology	biology	NN
cord-018764-02l423mk	187	8	.	.	.
cord-018764-02l423mk	188	1	Hyperlactataemia	Hyperlactataemia	NNP
cord-018764-02l423mk	188	2	may	may	MD
cord-018764-02l423mk	188	3	be	be	VB
cord-018764-02l423mk	188	4	associated	associate	VBN
cord-018764-02l423mk	188	5	with	with	IN
cord-018764-02l423mk	188	6	acidosis	acidosis	NN
cord-018764-02l423mk	188	7	,	,	,
cord-018764-02l423mk	188	8	a	a	DT
cord-018764-02l423mk	188	9	normal	normal	JJ
cord-018764-02l423mk	188	10	pH	ph	NN
cord-018764-02l423mk	188	11	,	,	,
cord-018764-02l423mk	188	12	or	or	CC
cord-018764-02l423mk	188	13	alkalosis	alkalosis	NN
cord-018764-02l423mk	188	14	[	[	-LRB-
cord-018764-02l423mk	188	15	123	123	CD
cord-018764-02l423mk	188	16	]	]	-RRB-
cord-018764-02l423mk	188	17	.	.	.
cord-018764-02l423mk	189	1	A	a	DT
cord-018764-02l423mk	189	2	recent	recent	JJ
cord-018764-02l423mk	189	3	editorial	editorial	NN
cord-018764-02l423mk	189	4	in	in	IN
cord-018764-02l423mk	189	5	Critical	Critical	NNP
cord-018764-02l423mk	189	6	Care	Care	NNP
cord-018764-02l423mk	189	7	Medicine	Medicine	NNP
cord-018764-02l423mk	189	8	[	[	-LRB-
cord-018764-02l423mk	189	9	124	124	CD
cord-018764-02l423mk	189	10	]	]	-RRB-
cord-018764-02l423mk	189	11	has	have	VBZ
cord-018764-02l423mk	189	12	lucidly	lucidly	RB
cord-018764-02l423mk	189	13	summarised	summarise	VBN
cord-018764-02l423mk	189	14	the	the	DT
cord-018764-02l423mk	189	15	key	key	JJ
cord-018764-02l423mk	189	16	points	point	NNS
cord-018764-02l423mk	189	17	of	of	IN
cord-018764-02l423mk	189	18	the	the	DT
cord-018764-02l423mk	189	19	mechanism	mechanism	NN
cord-018764-02l423mk	189	20	of	of	IN
cord-018764-02l423mk	189	21	metabolic	metabolic	JJ
cord-018764-02l423mk	189	22	acidosis	acidosis	NN
cord-018764-02l423mk	189	23	in	in	IN
cord-018764-02l423mk	189	24	sepsis	sepsis	NN
cord-018764-02l423mk	189	25	,	,	,
cord-018764-02l423mk	189	26	a	a	DT
cord-018764-02l423mk	189	27	condition	condition	NN
cord-018764-02l423mk	189	28	that	that	WDT
cord-018764-02l423mk	189	29	shares	share	VBZ
cord-018764-02l423mk	189	30	systemic	systemic	JJ
cord-018764-02l423mk	189	31	inflammation	inflammation	NN
cord-018764-02l423mk	189	32	and	and	CC
cord-018764-02l423mk	189	33	a	a	DT
cord-018764-02l423mk	189	34	range	range	NN
cord-018764-02l423mk	189	35	of	of	IN
cord-018764-02l423mk	189	36	its	-PRON-	PRP$
cord-018764-02l423mk	189	37	consequences	consequence	NNS
cord-018764-02l423mk	189	38	with	with	IN
cord-018764-02l423mk	189	39	severe	severe	JJ
cord-018764-02l423mk	189	40	malaria	malaria	NN
cord-018764-02l423mk	189	41	(	(	-LRB-
cord-018764-02l423mk	189	42	Tab	Tab	NNP
cord-018764-02l423mk	189	43	.	.	.
cord-018764-02l423mk	189	44	2	2	CD
cord-018764-02l423mk	189	45	)	)	-RRB-
cord-018764-02l423mk	189	46	.	.	.
cord-018764-02l423mk	190	1	These	these	DT
cord-018764-02l423mk	190	2	authors	author	NNS
cord-018764-02l423mk	190	3	argue	argue	VBP
cord-018764-02l423mk	190	4	against	against	IN
cord-018764-02l423mk	190	5	lactate	lactate	NN
cord-018764-02l423mk	190	6	as	as	IN
cord-018764-02l423mk	190	7	the	the	DT
cord-018764-02l423mk	190	8	cause	cause	NN
cord-018764-02l423mk	190	9	of	of	IN
cord-018764-02l423mk	190	10	the	the	DT
cord-018764-02l423mk	190	11	acidosis	acidosis	NN
cord-018764-02l423mk	190	12	associated	associate	VBN
cord-018764-02l423mk	190	13	with	with	IN
cord-018764-02l423mk	190	14	hypoxia	hypoxia	NN
cord-018764-02l423mk	190	15	.	.	.
cord-018764-02l423mk	191	1	Instead	instead	RB
cord-018764-02l423mk	191	2	,	,	,
cord-018764-02l423mk	191	3	they	-PRON-	PRP
cord-018764-02l423mk	191	4	note	note	VBP
cord-018764-02l423mk	191	5	the	the	DT
cord-018764-02l423mk	191	6	evidence	evidence	NN
cord-018764-02l423mk	191	7	that	that	IN
cord-018764-02l423mk	191	8	during	during	IN
cord-018764-02l423mk	191	9	hypoxia	hypoxia	NN
cord-018764-02l423mk	191	10	,	,	,
cord-018764-02l423mk	191	11	be	be	VB
cord-018764-02l423mk	191	12	it	-PRON-	PRP
cord-018764-02l423mk	191	13	from	from	IN
cord-018764-02l423mk	191	14	limited	limited	JJ
cord-018764-02l423mk	191	15	oxygen	oxygen	NN
cord-018764-02l423mk	191	16	supply	supply	NN
cord-018764-02l423mk	191	17	or	or	CC
cord-018764-02l423mk	191	18	utilisation	utilisation	NN
cord-018764-02l423mk	191	19	,	,	,
cord-018764-02l423mk	191	20	the	the	DT
cord-018764-02l423mk	191	21	unconsumed	unconsumed	JJ
cord-018764-02l423mk	191	22	protons	proton	NNS
cord-018764-02l423mk	191	23	that	that	WDT
cord-018764-02l423mk	191	24	cause	cause	VBP
cord-018764-02l423mk	191	25	acidosis	acidosis	NN
cord-018764-02l423mk	191	26	arise	arise	VBP
cord-018764-02l423mk	191	27	from	from	IN
cord-018764-02l423mk	191	28	the	the	DT
cord-018764-02l423mk	191	29	hydrolysis	hydrolysis	NN
cord-018764-02l423mk	191	30	of	of	IN
cord-018764-02l423mk	191	31	non	non	JJ
cord-018764-02l423mk	191	32	-	-	JJ
cord-018764-02l423mk	191	33	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	191	34	ATP	ATP	NNP
cord-018764-02l423mk	191	35	.	.	.
cord-018764-02l423mk	192	1	Since	since	IN
cord-018764-02l423mk	192	2	these	these	DT
cord-018764-02l423mk	192	3	reactions	reaction	NNS
cord-018764-02l423mk	192	4	are	be	VBP
cord-018764-02l423mk	192	5	independent	independent	JJ
cord-018764-02l423mk	192	6	of	of	IN
cord-018764-02l423mk	192	7	lactate	lactate	NN
cord-018764-02l423mk	192	8	levels	level	NNS
cord-018764-02l423mk	192	9	,	,	,
cord-018764-02l423mk	192	10	it	-PRON-	PRP
cord-018764-02l423mk	192	11	is	be	VBZ
cord-018764-02l423mk	192	12	difficult	difficult	JJ
cord-018764-02l423mk	192	13	to	to	TO
cord-018764-02l423mk	192	14	see	see	VB
cord-018764-02l423mk	192	15	how	how	WRB
cord-018764-02l423mk	192	16	therapeutically	therapeutically	RB
cord-018764-02l423mk	192	17	reducing	reduce	VBG
cord-018764-02l423mk	192	18	levels	level	NNS
cord-018764-02l423mk	192	19	of	of	IN
cord-018764-02l423mk	192	20	this	this	DT
cord-018764-02l423mk	192	21	anion	anion	NN
cord-018764-02l423mk	192	22	,	,	,
cord-018764-02l423mk	192	23	as	as	IN
cord-018764-02l423mk	192	24	has	have	VBZ
cord-018764-02l423mk	192	25	been	be	VBN
cord-018764-02l423mk	192	26	proposed	propose	VBN
cord-018764-02l423mk	192	27	[	[	-LRB-
cord-018764-02l423mk	192	28	125	125	CD
cord-018764-02l423mk	192	29	]	]	-RRB-
cord-018764-02l423mk	192	30	,	,	,
cord-018764-02l423mk	192	31	could	could	MD
cord-018764-02l423mk	192	32	increase	increase	VB
cord-018764-02l423mk	192	33	survival	survival	NN
cord-018764-02l423mk	192	34	rate	rate	NN
cord-018764-02l423mk	192	35	in	in	IN
cord-018764-02l423mk	192	36	falciparum	falciparum	NN
cord-018764-02l423mk	192	37	malaria	malaria	NN
cord-018764-02l423mk	192	38	any	any	DT
cord-018764-02l423mk	192	39	more	more	JJR
cord-018764-02l423mk	192	40	than	than	IN
cord-018764-02l423mk	192	41	in	in	IN
cord-018764-02l423mk	192	42	sepsis	sepsis	NN
cord-018764-02l423mk	192	43	[	[	-LRB-
cord-018764-02l423mk	192	44	126	126	CD
cord-018764-02l423mk	192	45	]	]	-RRB-
cord-018764-02l423mk	192	46	.	.	.
cord-018764-02l423mk	193	1	Indeed	indeed	RB
cord-018764-02l423mk	193	2	,	,	,
cord-018764-02l423mk	193	3	in	in	IN
cord-018764-02l423mk	193	4	theory	theory	NN
cord-018764-02l423mk	193	5	it	-PRON-	PRP
cord-018764-02l423mk	193	6	could	could	MD
cord-018764-02l423mk	193	7	harm	harm	VB
cord-018764-02l423mk	193	8	comatose	comatose	JJ
cord-018764-02l423mk	193	9	patients	patient	NNS
cord-018764-02l423mk	193	10	,	,	,
cord-018764-02l423mk	193	11	since	since	IN
cord-018764-02l423mk	193	12	there	there	EX
cord-018764-02l423mk	193	13	is	be	VBZ
cord-018764-02l423mk	193	14	evidence	evidence	NN
cord-018764-02l423mk	193	15	that	that	IN
cord-018764-02l423mk	193	16	lactate	lactate	NN
cord-018764-02l423mk	193	17	helps	help	VBZ
cord-018764-02l423mk	193	18	brain	brain	NN
cord-018764-02l423mk	193	19	tissue	tissue	NN
cord-018764-02l423mk	193	20	survive	survive	VBP
cord-018764-02l423mk	193	21	hypoxic	hypoxic	JJ
cord-018764-02l423mk	193	22	and	and	CC
cord-018764-02l423mk	193	23	hypoglycaemic	hypoglycaemic	JJ
cord-018764-02l423mk	193	24	episodes	episode	NNS
cord-018764-02l423mk	193	25	[	[	-LRB-
cord-018764-02l423mk	193	26	127	127	CD
cord-018764-02l423mk	193	27	]	]	-RRB-
cord-018764-02l423mk	193	28	[	[	-LRB-
cord-018764-02l423mk	193	29	128	128	CD
cord-018764-02l423mk	193	30	]	]	-RRB-
cord-018764-02l423mk	193	31	[	[	-LRB-
cord-018764-02l423mk	193	32	129	129	CD
cord-018764-02l423mk	193	33	]	]	-RRB-
cord-018764-02l423mk	193	34	,	,	,
cord-018764-02l423mk	193	35	and	and	CC
cord-018764-02l423mk	193	36	the	the	DT
cord-018764-02l423mk	193	37	lactate	lactate	NN
cord-018764-02l423mk	193	38	shuttle	shuttle	NN
cord-018764-02l423mk	193	39	is	be	VBZ
cord-018764-02l423mk	193	40	proving	prove	VBG
cord-018764-02l423mk	193	41	to	to	TO
cord-018764-02l423mk	193	42	be	be	VB
cord-018764-02l423mk	193	43	how	how	WRB
cord-018764-02l423mk	193	44	astrocytes	astrocytes	JJ
cord-018764-02l423mk	193	45	protect	protect	VBP
cord-018764-02l423mk	193	46	neurons	neuron	NNS
cord-018764-02l423mk	193	47	from	from	IN
cord-018764-02l423mk	193	48	metabolic	metabolic	JJ
cord-018764-02l423mk	193	49	stress	stress	NN
cord-018764-02l423mk	193	50	[	[	-LRB-
cord-018764-02l423mk	193	51	130	130	CD
cord-018764-02l423mk	193	52	]	]	-RRB-
cord-018764-02l423mk	193	53	.	.	.
cord-018764-02l423mk	194	1	Even	even	RB
cord-018764-02l423mk	194	2	when	when	WRB
cord-018764-02l423mk	194	3	considerable	considerable	JJ
cord-018764-02l423mk	194	4	lactate	lactate	NN
cord-018764-02l423mk	194	5	is	be	VBZ
cord-018764-02l423mk	194	6	generated	generate	VBN
cord-018764-02l423mk	194	7	in	in	IN
cord-018764-02l423mk	194	8	acute	acute	JJ
cord-018764-02l423mk	194	9	inflammatory	inflammatory	JJ
cord-018764-02l423mk	194	10	states	state	NNS
cord-018764-02l423mk	194	11	,	,	,
cord-018764-02l423mk	194	12	other	other	JJ
cord-018764-02l423mk	194	13	,	,	,
cord-018764-02l423mk	194	14	unidentified	unidentified	JJ
cord-018764-02l423mk	194	15	,	,	,
cord-018764-02l423mk	194	16	anions	anion	NNS
cord-018764-02l423mk	194	17	contribute	contribute	VBP
cord-018764-02l423mk	194	18	much	much	RB
cord-018764-02l423mk	194	19	more	more	JJR
cord-018764-02l423mk	194	20	than	than	IN
cord-018764-02l423mk	194	21	it	-PRON-	PRP
cord-018764-02l423mk	194	22	does	do	VBZ
cord-018764-02l423mk	194	23	to	to	IN
cord-018764-02l423mk	194	24	the	the	DT
cord-018764-02l423mk	194	25	strong	strong	JJ
cord-018764-02l423mk	194	26	ion	ion	NN
cord-018764-02l423mk	194	27	difference	difference	NN
cord-018764-02l423mk	194	28	that	that	WDT
cord-018764-02l423mk	194	29	,	,	,
cord-018764-02l423mk	194	30	through	through	IN
cord-018764-02l423mk	194	31	influencing	influence	VBG
cord-018764-02l423mk	194	32	the	the	DT
cord-018764-02l423mk	194	33	body	body	NN
cord-018764-02l423mk	194	34	's	's	POS
cord-018764-02l423mk	194	35	buffering	buffering	NN
cord-018764-02l423mk	194	36	capacity	capacity	NN
cord-018764-02l423mk	194	37	,	,	,
cord-018764-02l423mk	194	38	influences	influence	NNS
cord-018764-02l423mk	194	39	acidosis	acidosis	NN
cord-018764-02l423mk	194	40	in	in	IN
cord-018764-02l423mk	194	41	sepsis	sepsis	NN
cord-018764-02l423mk	194	42	[	[	-LRB-
cord-018764-02l423mk	194	43	131	131	CD
cord-018764-02l423mk	194	44	,	,	,
cord-018764-02l423mk	194	45	132	132	CD
cord-018764-02l423mk	194	46	]	]	-RRB-
cord-018764-02l423mk	194	47	and	and	CC
cord-018764-02l423mk	194	48	falciparum	falciparum	NN
cord-018764-02l423mk	194	49	malaria	malaria	NN
cord-018764-02l423mk	194	50	[	[	-LRB-
cord-018764-02l423mk	194	51	114	114	CD
cord-018764-02l423mk	194	52	,	,	,
cord-018764-02l423mk	194	53	133	133	CD
cord-018764-02l423mk	194	54	]	]	-RRB-
cord-018764-02l423mk	194	55	.	.	.
cord-018764-02l423mk	195	1	Thus	thus	RB
cord-018764-02l423mk	195	2	,	,	,
cord-018764-02l423mk	195	3	lactate	lactate	NN
cord-018764-02l423mk	195	4	accumulation	accumulation	NN
cord-018764-02l423mk	195	5	can	can	MD
cord-018764-02l423mk	195	6	only	only	RB
cord-018764-02l423mk	195	7	partially	partially	RB
cord-018764-02l423mk	195	8	account	account	VB
cord-018764-02l423mk	195	9	for	for	IN
cord-018764-02l423mk	195	10	the	the	DT
cord-018764-02l423mk	195	11	high	high	JJ
cord-018764-02l423mk	195	12	anion	anion	NN
cord-018764-02l423mk	195	13	gap	gap	NN
cord-018764-02l423mk	195	14	observed	observe	VBD
cord-018764-02l423mk	195	15	during	during	IN
cord-018764-02l423mk	195	16	the	the	DT
cord-018764-02l423mk	195	17	metabolic	metabolic	JJ
cord-018764-02l423mk	195	18	acidosis	acidosis	NN
cord-018764-02l423mk	195	19	associated	associate	VBN
cord-018764-02l423mk	195	20	with	with	IN
cord-018764-02l423mk	195	21	severe	severe	JJ
cord-018764-02l423mk	195	22	malaria	malaria	NN
cord-018764-02l423mk	195	23	.	.	.
cord-018764-02l423mk	196	1	In	in	IN
cord-018764-02l423mk	196	2	summary	summary	NN
cord-018764-02l423mk	196	3	,	,	,
cord-018764-02l423mk	196	4	lactate	lactate	NN
cord-018764-02l423mk	196	5	is	be	VBZ
cord-018764-02l423mk	196	6	an	an	DT
cord-018764-02l423mk	196	7	imprecise	imprecise	JJ
cord-018764-02l423mk	196	8	but	but	CC
cord-018764-02l423mk	196	9	useful	useful	JJ
cord-018764-02l423mk	196	10	marker	marker	NN
cord-018764-02l423mk	196	11	for	for	IN
cord-018764-02l423mk	196	12	metabolic	metabolic	JJ
cord-018764-02l423mk	196	13	acidosis	acidosis	NN
cord-018764-02l423mk	196	14	in	in	IN
cord-018764-02l423mk	196	15	malaria	malaria	NN
cord-018764-02l423mk	196	16	.	.	.
cord-018764-02l423mk	197	1	In	in	IN
cord-018764-02l423mk	197	2	turn	turn	NN
cord-018764-02l423mk	197	3	,	,	,
cord-018764-02l423mk	197	4	acidosis	acidosis	NN
cord-018764-02l423mk	197	5	is	be	VBZ
cord-018764-02l423mk	197	6	an	an	DT
cord-018764-02l423mk	197	7	imprecise	imprecise	JJ
cord-018764-02l423mk	197	8	but	but	CC
cord-018764-02l423mk	197	9	useful	useful	JJ
cord-018764-02l423mk	197	10	marker	marker	NN
cord-018764-02l423mk	197	11	of	of	IN
cord-018764-02l423mk	197	12	impaired	impaired	JJ
cord-018764-02l423mk	197	13	cellular	cellular	JJ
cord-018764-02l423mk	197	14	respiration	respiration	NN
cord-018764-02l423mk	197	15	.	.	.
cord-018764-02l423mk	198	1	Whether	whether	IN
cord-018764-02l423mk	198	2	impaired	impaired	JJ
cord-018764-02l423mk	198	3	cellular	cellular	JJ
cord-018764-02l423mk	198	4	respiration	respiration	NN
cord-018764-02l423mk	198	5	arises	arise	VBZ
cord-018764-02l423mk	198	6	from	from	IN
cord-018764-02l423mk	198	7	(	(	-LRB-
cord-018764-02l423mk	198	8	a	a	DT
cord-018764-02l423mk	198	9	)	)	-RRB-
cord-018764-02l423mk	198	10	poor	poor	JJ
cord-018764-02l423mk	198	11	supply	supply	NN
cord-018764-02l423mk	198	12	of	of	IN
cord-018764-02l423mk	198	13	oxygen	oxygen	NN
cord-018764-02l423mk	198	14	to	to	IN
cord-018764-02l423mk	198	15	mitochondria	mitochondrion	NNS
cord-018764-02l423mk	198	16	(	(	-LRB-
cord-018764-02l423mk	198	17	through	through	IN
cord-018764-02l423mk	198	18	vaso	vaso	NNP
cord-018764-02l423mk	198	19	-	-	HYPH
cord-018764-02l423mk	198	20	occlusion	occlusion	NN
cord-018764-02l423mk	198	21	,	,	,
cord-018764-02l423mk	198	22	low	low	JJ
cord-018764-02l423mk	198	23	circulating	circulate	VBG
cord-018764-02l423mk	198	24	volume	volume	NN
cord-018764-02l423mk	198	25	,	,	,
cord-018764-02l423mk	198	26	anaemia	anaemia	NN
cord-018764-02l423mk	198	27	or	or	CC
cord-018764-02l423mk	198	28	cardiac	cardiac	JJ
cord-018764-02l423mk	198	29	insufficiency	insufficiency	NN
cord-018764-02l423mk	198	30	)	)	-RRB-
cord-018764-02l423mk	198	31	or	or	CC
cord-018764-02l423mk	198	32	impaired	impair	VBN
cord-018764-02l423mk	198	33	mitochondrial	mitochondrial	NN
cord-018764-02l423mk	198	34	function	function	NN
cord-018764-02l423mk	198	35	(	(	-LRB-
cord-018764-02l423mk	198	36	in	in	IN
cord-018764-02l423mk	198	37	response	response	NN
cord-018764-02l423mk	198	38	to	to	IN
cord-018764-02l423mk	198	39	severe	severe	JJ
cord-018764-02l423mk	198	40	systemic	systemic	JJ
cord-018764-02l423mk	198	41	inflammation	inflammation	NN
cord-018764-02l423mk	198	42	)	)	-RRB-
cord-018764-02l423mk	198	43	the	the	DT
cord-018764-02l423mk	198	44	outcome	outcome	NN
cord-018764-02l423mk	198	45	is	be	VBZ
cord-018764-02l423mk	198	46	essentially	essentially	RB
cord-018764-02l423mk	198	47	the	the	DT
cord-018764-02l423mk	198	48	same	same	JJ
cord-018764-02l423mk	198	49	.	.	.
cord-018764-02l423mk	199	1	The	the	DT
cord-018764-02l423mk	199	2	resulting	result	VBG
cord-018764-02l423mk	199	3	high	high	JJ
cord-018764-02l423mk	199	4	anion	anion	NN
cord-018764-02l423mk	199	5	gap	gap	NN
cord-018764-02l423mk	199	6	metabolic	metabolic	JJ
cord-018764-02l423mk	199	7	acidosis	acidosis	NN
cord-018764-02l423mk	199	8	is	be	VBZ
cord-018764-02l423mk	199	9	strongly	strongly	RB
cord-018764-02l423mk	199	10	predictive	predictive	JJ
cord-018764-02l423mk	199	11	of	of	IN
cord-018764-02l423mk	199	12	death	death	NN
cord-018764-02l423mk	199	13	in	in	IN
cord-018764-02l423mk	199	14	severe	severe	JJ
cord-018764-02l423mk	199	15	malaria	malaria	NN
cord-018764-02l423mk	199	16	.	.	.
cord-018764-02l423mk	200	1	Greater	great	JJR
cord-018764-02l423mk	200	2	understanding	understanding	NN
cord-018764-02l423mk	200	3	of	of	IN
cord-018764-02l423mk	200	4	the	the	DT
cord-018764-02l423mk	200	5	multiple	multiple	JJ
cord-018764-02l423mk	200	6	factors	factor	NNS
cord-018764-02l423mk	200	7	influencing	influence	VBG
cord-018764-02l423mk	200	8	the	the	DT
cord-018764-02l423mk	200	9	metabolic	metabolic	JJ
cord-018764-02l423mk	200	10	acidosis	acidosis	NN
cord-018764-02l423mk	200	11	could	could	MD
cord-018764-02l423mk	200	12	provide	provide	VB
cord-018764-02l423mk	200	13	further	further	JJ
cord-018764-02l423mk	200	14	insight	insight	NN
cord-018764-02l423mk	200	15	into	into	IN
cord-018764-02l423mk	200	16	the	the	DT
cord-018764-02l423mk	200	17	underlying	underlie	VBG
cord-018764-02l423mk	200	18	pathophysiological	pathophysiological	JJ
cord-018764-02l423mk	200	19	process	process	NN
cord-018764-02l423mk	200	20	and	and	CC
cord-018764-02l423mk	200	21	may	may	MD
cord-018764-02l423mk	200	22	provide	provide	VB
cord-018764-02l423mk	200	23	additional	additional	JJ
cord-018764-02l423mk	200	24	therapeutic	therapeutic	JJ
cord-018764-02l423mk	200	25	options	option	NNS
cord-018764-02l423mk	200	26	.	.	.
cord-018764-02l423mk	201	1	When	when	WRB
cord-018764-02l423mk	201	2	glycolysis	glycolysis	NN
cord-018764-02l423mk	201	3	is	be	VBZ
cord-018764-02l423mk	201	4	enhanced	enhance	VBN
cord-018764-02l423mk	201	5	for	for	IN
cord-018764-02l423mk	201	6	any	any	DT
cord-018764-02l423mk	201	7	period	period	NN
cord-018764-02l423mk	201	8	glycogen	glycogen	NN
cord-018764-02l423mk	201	9	stores	store	NNS
cord-018764-02l423mk	201	10	are	be	VBP
cord-018764-02l423mk	201	11	soon	soon	RB
cord-018764-02l423mk	201	12	depleted	deplete	VBN
cord-018764-02l423mk	201	13	,	,	,
cord-018764-02l423mk	201	14	and	and	CC
cord-018764-02l423mk	201	15	gluconeogenesis	gluconeogenesis	NN
cord-018764-02l423mk	201	16	supervenes	supervene	VBZ
cord-018764-02l423mk	201	17	.	.	.
cord-018764-02l423mk	202	1	However	however	RB
cord-018764-02l423mk	202	2	,	,	,
cord-018764-02l423mk	202	3	its	-PRON-	PRP$
cord-018764-02l423mk	202	4	substrate	substrate	NN
cord-018764-02l423mk	202	5	supplies	supply	NNS
cord-018764-02l423mk	202	6	are	be	VBP
cord-018764-02l423mk	202	7	limiting	limit	VBG
cord-018764-02l423mk	202	8	[	[	-LRB-
cord-018764-02l423mk	202	9	134	134	CD
cord-018764-02l423mk	202	10	]	]	-RRB-
cord-018764-02l423mk	202	11	,	,	,
cord-018764-02l423mk	202	12	and	and	CC
cord-018764-02l423mk	202	13	the	the	DT
cord-018764-02l423mk	202	14	hypoglycaemia	hypoglycaemia	NN
cord-018764-02l423mk	202	15	often	often	RB
cord-018764-02l423mk	202	16	reported	report	VBD
cord-018764-02l423mk	202	17	in	in	IN
cord-018764-02l423mk	202	18	severe	severe	JJ
cord-018764-02l423mk	202	19	malaria	malaria	NN
cord-018764-02l423mk	202	20	[	[	-LRB-
cord-018764-02l423mk	202	21	135	135	CD
cord-018764-02l423mk	202	22	]	]	-RRB-
cord-018764-02l423mk	202	23	and	and	CC
cord-018764-02l423mk	202	24	sepsis	sepsis	NN
cord-018764-02l423mk	202	25	[	[	-LRB-
cord-018764-02l423mk	202	26	19	19	CD
cord-018764-02l423mk	202	27	,	,	,
cord-018764-02l423mk	202	28	136	136	CD
cord-018764-02l423mk	202	29	]	]	-RRB-
cord-018764-02l423mk	202	30	occurs	occur	VBZ
cord-018764-02l423mk	202	31	.	.	.
cord-018764-02l423mk	203	1	Hypoglycaemia	Hypoglycaemia	NNP
cord-018764-02l423mk	203	2	is	be	VBZ
cord-018764-02l423mk	203	3	therefore	therefore	RB
cord-018764-02l423mk	203	4	a	a	DT
cord-018764-02l423mk	203	5	secondary	secondary	JJ
cord-018764-02l423mk	203	6	cause	cause	NN
cord-018764-02l423mk	203	7	of	of	IN
cord-018764-02l423mk	203	8	harm	harm	NN
cord-018764-02l423mk	203	9	in	in	IN
cord-018764-02l423mk	203	10	these	these	DT
cord-018764-02l423mk	203	11	diseases	disease	NNS
cord-018764-02l423mk	203	12	,	,	,
cord-018764-02l423mk	203	13	and	and	CC
cord-018764-02l423mk	203	14	is	be	VBZ
cord-018764-02l423mk	203	15	an	an	DT
cord-018764-02l423mk	203	16	inevitable	inevitable	JJ
cord-018764-02l423mk	203	17	consequence	consequence	NN
cord-018764-02l423mk	203	18	of	of	IN
cord-018764-02l423mk	203	19	exuberant	exuberant	JJ
cord-018764-02l423mk	203	20	,	,	,
cord-018764-02l423mk	203	21	mostly	mostly	RB
cord-018764-02l423mk	203	22	anaerobic	anaerobic	JJ
cord-018764-02l423mk	203	23	,	,	,
cord-018764-02l423mk	203	24	glycolysis	glycolysis	NN
cord-018764-02l423mk	203	25	.	.	.
cord-018764-02l423mk	204	1	CM	CM	NNP
cord-018764-02l423mk	204	2	is	be	VBZ
cord-018764-02l423mk	204	3	a	a	DT
cord-018764-02l423mk	204	4	clinical	clinical	JJ
cord-018764-02l423mk	204	5	syndrome	syndrome	NN
cord-018764-02l423mk	204	6	characterised	characterise	VBN
cord-018764-02l423mk	204	7	by	by	IN
cord-018764-02l423mk	204	8	coma	coma	NN
cord-018764-02l423mk	204	9	(	(	-LRB-
cord-018764-02l423mk	204	10	inability	inability	NN
cord-018764-02l423mk	204	11	to	to	TO
cord-018764-02l423mk	204	12	localise	localise	VB
cord-018764-02l423mk	204	13	a	a	DT
cord-018764-02l423mk	204	14	painful	painful	JJ
cord-018764-02l423mk	204	15	stimulus	stimulus	NN
cord-018764-02l423mk	204	16	)	)	-RRB-
cord-018764-02l423mk	204	17	at	at	IN
cord-018764-02l423mk	204	18	least	least	JJS
cord-018764-02l423mk	204	19	1	1	CD
cord-018764-02l423mk	204	20	h	h	NN
cord-018764-02l423mk	204	21	after	after	IN
cord-018764-02l423mk	204	22	termination	termination	NN
cord-018764-02l423mk	204	23	of	of	IN
cord-018764-02l423mk	204	24	a	a	DT
cord-018764-02l423mk	204	25	seizure	seizure	NN
cord-018764-02l423mk	204	26	or	or	CC
cord-018764-02l423mk	204	27	correction	correction	NN
cord-018764-02l423mk	204	28	of	of	IN
cord-018764-02l423mk	204	29	hypoglycaemia	hypoglycaemia	NN
cord-018764-02l423mk	204	30	,	,	,
cord-018764-02l423mk	204	31	detection	detection	NN
cord-018764-02l423mk	204	32	of	of	IN
cord-018764-02l423mk	204	33	asexual	asexual	JJ
cord-018764-02l423mk	204	34	forms	form	NNS
cord-018764-02l423mk	204	35	of	of	IN
cord-018764-02l423mk	204	36	P.	P.	NNP
cord-018764-02l423mk	204	37	falciparum	falciparum	NN
cord-018764-02l423mk	204	38	malarial	malarial	JJ
cord-018764-02l423mk	204	39	parasites	parasite	NNS
cord-018764-02l423mk	204	40	on	on	IN
cord-018764-02l423mk	204	41	peripheral	peripheral	JJ
cord-018764-02l423mk	204	42	blood	blood	NN
cord-018764-02l423mk	204	43	smears	smear	NNS
cord-018764-02l423mk	204	44	,	,	,
cord-018764-02l423mk	204	45	and	and	CC
cord-018764-02l423mk	204	46	exclusion	exclusion	NN
cord-018764-02l423mk	204	47	of	of	IN
cord-018764-02l423mk	204	48	other	other	JJ
cord-018764-02l423mk	204	49	causes	cause	NNS
cord-018764-02l423mk	204	50	of	of	IN
cord-018764-02l423mk	204	51	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	204	52	[	[	-LRB-
cord-018764-02l423mk	204	53	137	137	CD
cord-018764-02l423mk	204	54	]	]	-RRB-
cord-018764-02l423mk	204	55	.	.	.
cord-018764-02l423mk	205	1	A	a	DT
cord-018764-02l423mk	205	2	relatively	relatively	RB
cord-018764-02l423mk	205	3	consistent	consistent	JJ
cord-018764-02l423mk	205	4	feature	feature	NN
cord-018764-02l423mk	205	5	of	of	IN
cord-018764-02l423mk	205	6	acute	acute	JJ
cord-018764-02l423mk	205	7	CM	cm	NN
cord-018764-02l423mk	205	8	in	in	IN
cord-018764-02l423mk	205	9	children	child	NNS
cord-018764-02l423mk	205	10	is	be	VBZ
cord-018764-02l423mk	205	11	raised	raise	VBN
cord-018764-02l423mk	205	12	intracranial	intracranial	JJ
cord-018764-02l423mk	205	13	pressure	pressure	NN
cord-018764-02l423mk	205	14	(	(	-LRB-
cord-018764-02l423mk	205	15	ICP	ICP	NNP
cord-018764-02l423mk	205	16	)	)	-RRB-
cord-018764-02l423mk	205	17	.	.	.
cord-018764-02l423mk	206	1	Studies	study	NNS
cord-018764-02l423mk	206	2	in	in	IN
cord-018764-02l423mk	206	3	African	african	JJ
cord-018764-02l423mk	206	4	children	child	NNS
cord-018764-02l423mk	206	5	have	have	VBP
cord-018764-02l423mk	206	6	demonstrated	demonstrate	VBN
cord-018764-02l423mk	206	7	a	a	DT
cord-018764-02l423mk	206	8	raised	raise	VBN
cord-018764-02l423mk	206	9	cerebrospinal	cerebrospinal	JJ
cord-018764-02l423mk	206	10	fluid	fluid	NN
cord-018764-02l423mk	206	11	(	(	-LRB-
cord-018764-02l423mk	206	12	CSF	CSF	NNP
cord-018764-02l423mk	206	13	)	)	-RRB-
cord-018764-02l423mk	206	14	opening	open	VBG
cord-018764-02l423mk	206	15	pressure	pressure	NN
cord-018764-02l423mk	206	16	during	during	IN
cord-018764-02l423mk	206	17	lumbar	lumbar	JJ
cord-018764-02l423mk	206	18	puncture	puncture	NN
cord-018764-02l423mk	206	19	in	in	IN
cord-018764-02l423mk	206	20	80	80	CD
cord-018764-02l423mk	206	21	%	%	NN
cord-018764-02l423mk	206	22	of	of	IN
cord-018764-02l423mk	206	23	CM	cm	NN
cord-018764-02l423mk	206	24	children	child	NNS
cord-018764-02l423mk	206	25	[	[	-LRB-
cord-018764-02l423mk	206	26	138	138	CD
cord-018764-02l423mk	206	27	]	]	-RRB-
cord-018764-02l423mk	206	28	,	,	,
cord-018764-02l423mk	206	29	raised	raise	VBD
cord-018764-02l423mk	206	30	ICP	ICP	NNP
cord-018764-02l423mk	206	31	during	during	IN
cord-018764-02l423mk	206	32	intracranial	intracranial	JJ
cord-018764-02l423mk	206	33	pressure	pressure	NN
cord-018764-02l423mk	206	34	monitoring	monitoring	NN
cord-018764-02l423mk	206	35	(	(	-LRB-
cord-018764-02l423mk	206	36	23/23	23/23	CD
cord-018764-02l423mk	206	37	ICP	ICP	NNP
cord-018764-02l423mk	206	38	>	>	XX
cord-018764-02l423mk	206	39	10	10	CD
cord-018764-02l423mk	206	40	mmHg	mmHg	NNS
cord-018764-02l423mk	206	41	)	)	-RRB-
cord-018764-02l423mk	206	42	[	[	-LRB-
cord-018764-02l423mk	206	43	139	139	CD
cord-018764-02l423mk	206	44	]	]	-RRB-
cord-018764-02l423mk	206	45	and	and	CC
cord-018764-02l423mk	206	46	papilloedema	papilloedema	NNP
cord-018764-02l423mk	206	47	(	(	-LRB-
cord-018764-02l423mk	206	48	a	a	DT
cord-018764-02l423mk	206	49	late	late	JJ
cord-018764-02l423mk	206	50	sign	sign	NN
cord-018764-02l423mk	206	51	of	of	IN
cord-018764-02l423mk	206	52	raised	raise	VBN
cord-018764-02l423mk	206	53	ICP	ICP	NNP
cord-018764-02l423mk	206	54	)	)	-RRB-
cord-018764-02l423mk	206	55	in	in	IN
cord-018764-02l423mk	206	56	44	44	CD
cord-018764-02l423mk	206	57	%	%	NN
cord-018764-02l423mk	206	58	of	of	IN
cord-018764-02l423mk	206	59	CM	cm	NN
cord-018764-02l423mk	206	60	patients	patient	NNS
cord-018764-02l423mk	206	61	who	who	WP
cord-018764-02l423mk	206	62	died	die	VBD
cord-018764-02l423mk	206	63	[	[	-LRB-
cord-018764-02l423mk	206	64	140	140	CD
cord-018764-02l423mk	206	65	]	]	-RRB-
cord-018764-02l423mk	206	66	.	.	.
cord-018764-02l423mk	207	1	Where	where	WRB
cord-018764-02l423mk	207	2	computer	computer	NN
cord-018764-02l423mk	207	3	tomography	tomography	NN
cord-018764-02l423mk	207	4	has	have	VBZ
cord-018764-02l423mk	207	5	been	be	VBN
cord-018764-02l423mk	207	6	performed	perform	VBN
cord-018764-02l423mk	207	7	,	,	,
cord-018764-02l423mk	207	8	there	there	EX
cord-018764-02l423mk	207	9	was	be	VBD
cord-018764-02l423mk	207	10	evidence	evidence	NN
cord-018764-02l423mk	207	11	of	of	IN
cord-018764-02l423mk	207	12	diffuse	diffuse	JJ
cord-018764-02l423mk	207	13	brain	brain	NN
cord-018764-02l423mk	207	14	swelling	swell	VBG
cord-018764-02l423mk	207	15	in	in	IN
cord-018764-02l423mk	207	16	40	40	CD
cord-018764-02l423mk	207	17	%	%	NN
cord-018764-02l423mk	207	18	of	of	IN
cord-018764-02l423mk	207	19	patients	patient	NNS
cord-018764-02l423mk	207	20	[	[	-LRB-
cord-018764-02l423mk	207	21	139	139	CD
cord-018764-02l423mk	207	22	]	]	-RRB-
cord-018764-02l423mk	207	23	.	.	.
cord-018764-02l423mk	208	1	The	the	DT
cord-018764-02l423mk	208	2	cause	cause	NN
cord-018764-02l423mk	208	3	of	of	IN
cord-018764-02l423mk	208	4	the	the	DT
cord-018764-02l423mk	208	5	raised	raise	VBN
cord-018764-02l423mk	208	6	ICP	ICP	NNP
cord-018764-02l423mk	208	7	is	be	VBZ
cord-018764-02l423mk	208	8	likely	likely	JJ
cord-018764-02l423mk	208	9	to	to	TO
cord-018764-02l423mk	208	10	be	be	VB
cord-018764-02l423mk	208	11	multi	multi	JJ
cord-018764-02l423mk	208	12	-	-	JJ
cord-018764-02l423mk	208	13	factorial	factorial	JJ
cord-018764-02l423mk	208	14	and	and	CC
cord-018764-02l423mk	208	15	has	have	VBZ
cord-018764-02l423mk	208	16	been	be	VBN
cord-018764-02l423mk	208	17	postulated	postulate	VBN
cord-018764-02l423mk	208	18	to	to	TO
cord-018764-02l423mk	208	19	involve	involve	VB
cord-018764-02l423mk	208	20	both	both	DT
cord-018764-02l423mk	208	21	vasogenic	vasogenic	JJ
cord-018764-02l423mk	208	22	and	and	CC
cord-018764-02l423mk	208	23	cytotoxic	cytotoxic	JJ
cord-018764-02l423mk	208	24	patterns	pattern	NNS
cord-018764-02l423mk	208	25	of	of	IN
cord-018764-02l423mk	208	26	cerebral	cerebral	JJ
cord-018764-02l423mk	208	27	oedema	oedema	NN
cord-018764-02l423mk	208	28	.	.	.
cord-018764-02l423mk	209	1	Vasogenic	Vasogenic	NNP
cord-018764-02l423mk	209	2	oedema	oedema	NN
cord-018764-02l423mk	209	3	is	be	VBZ
cord-018764-02l423mk	209	4	characterised	characterise	VBN
cord-018764-02l423mk	209	5	by	by	IN
cord-018764-02l423mk	209	6	accumulation	accumulation	NN
cord-018764-02l423mk	209	7	of	of	IN
cord-018764-02l423mk	209	8	interstitial	interstitial	JJ
cord-018764-02l423mk	209	9	fluid	fluid	NN
cord-018764-02l423mk	209	10	within	within	IN
cord-018764-02l423mk	209	11	the	the	DT
cord-018764-02l423mk	209	12	brain	brain	NN
cord-018764-02l423mk	209	13	secondary	secondary	JJ
cord-018764-02l423mk	209	14	to	to	IN
cord-018764-02l423mk	209	15	increased	increase	VBN
cord-018764-02l423mk	209	16	permeability	permeability	NN
cord-018764-02l423mk	209	17	of	of	IN
cord-018764-02l423mk	209	18	the	the	DT
cord-018764-02l423mk	209	19	blood	blood	NN
cord-018764-02l423mk	209	20	-	-	HYPH
cord-018764-02l423mk	209	21	brain	brain	NN
cord-018764-02l423mk	209	22	barrier	barrier	NN
cord-018764-02l423mk	209	23	(	(	-LRB-
cord-018764-02l423mk	209	24	BBB	BBB	NNP
cord-018764-02l423mk	209	25	)	)	-RRB-
cord-018764-02l423mk	209	26	.	.	.
cord-018764-02l423mk	210	1	It	-PRON-	PRP
cord-018764-02l423mk	210	2	has	have	VBZ
cord-018764-02l423mk	210	3	been	be	VBN
cord-018764-02l423mk	210	4	demonstrated	demonstrate	VBN
cord-018764-02l423mk	210	5	in	in	IN
cord-018764-02l423mk	210	6	bacterial	bacterial	JJ
cord-018764-02l423mk	210	7	cerebral	cerebral	JJ
cord-018764-02l423mk	210	8	infections	infection	NNS
cord-018764-02l423mk	210	9	,	,	,
cord-018764-02l423mk	210	10	but	but	CC
cord-018764-02l423mk	210	11	evidence	evidence	NN
cord-018764-02l423mk	210	12	of	of	IN
cord-018764-02l423mk	210	13	significant	significant	JJ
cord-018764-02l423mk	210	14	disruption	disruption	NN
cord-018764-02l423mk	210	15	of	of	IN
cord-018764-02l423mk	210	16	the	the	DT
cord-018764-02l423mk	210	17	BBB	BBB	NNP
cord-018764-02l423mk	210	18	is	be	VBZ
cord-018764-02l423mk	210	19	not	not	RB
cord-018764-02l423mk	210	20	conclusive	conclusive	JJ
cord-018764-02l423mk	210	21	in	in	IN
cord-018764-02l423mk	210	22	CM	CM	NNP
cord-018764-02l423mk	210	23	[	[	-LRB-
cord-018764-02l423mk	210	24	141	141	CD
cord-018764-02l423mk	210	25	]	]	-RRB-
cord-018764-02l423mk	210	26	.	.	.
cord-018764-02l423mk	211	1	Others	other	NNS
cord-018764-02l423mk	211	2	have	have	VBP
cord-018764-02l423mk	211	3	proposed	propose	VBN
cord-018764-02l423mk	211	4	that	that	IN
cord-018764-02l423mk	211	5	ICAM-1	icam-1	NN
cord-018764-02l423mk	211	6	binding	bind	VBG
cord-018764-02l423mk	211	7	by	by	IN
cord-018764-02l423mk	211	8	infected	infected	JJ
cord-018764-02l423mk	211	9	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	211	10	may	may	MD
cord-018764-02l423mk	211	11	generate	generate	VB
cord-018764-02l423mk	211	12	a	a	DT
cord-018764-02l423mk	211	13	cascade	cascade	NN
cord-018764-02l423mk	211	14	of	of	IN
cord-018764-02l423mk	211	15	intracellular	intracellular	JJ
cord-018764-02l423mk	211	16	signalling	signal	VBG
cord-018764-02l423mk	211	17	events	event	NNS
cord-018764-02l423mk	211	18	that	that	WDT
cord-018764-02l423mk	211	19	disrupt	disrupt	VBP
cord-018764-02l423mk	211	20	the	the	DT
cord-018764-02l423mk	211	21	cytoskeletal	cytoskeletal	JJ
cord-018764-02l423mk	211	22	-	-	HYPH
cord-018764-02l423mk	211	23	cell	cell	NN
cord-018764-02l423mk	211	24	junction	junction	NN
cord-018764-02l423mk	211	25	structure	structure	NN
cord-018764-02l423mk	211	26	and	and	CC
cord-018764-02l423mk	211	27	cause	cause	VB
cord-018764-02l423mk	211	28	focal	focal	JJ
cord-018764-02l423mk	211	29	disruption	disruption	NN
cord-018764-02l423mk	211	30	to	to	IN
cord-018764-02l423mk	211	31	the	the	DT
cord-018764-02l423mk	211	32	BBB	BBB	NNP
cord-018764-02l423mk	211	33	[	[	-LRB-
cord-018764-02l423mk	211	34	142	142	CD
cord-018764-02l423mk	211	35	]	]	-RRB-
cord-018764-02l423mk	211	36	.	.	.
cord-018764-02l423mk	212	1	Adult	adult	JJ
cord-018764-02l423mk	212	2	post	post	JJ
cord-018764-02l423mk	212	3	-	-	JJ
cord-018764-02l423mk	212	4	mortem	mortem	JJ
cord-018764-02l423mk	212	5	analysis	analysis	NN
cord-018764-02l423mk	212	6	has	have	VBZ
cord-018764-02l423mk	212	7	shown	show	VBN
cord-018764-02l423mk	212	8	cerebrovascular	cerebrovascular	JJ
cord-018764-02l423mk	212	9	endothelial	endothelial	JJ
cord-018764-02l423mk	212	10	cell	cell	NN
cord-018764-02l423mk	212	11	activation	activation	NN
cord-018764-02l423mk	212	12	(	(	-LRB-
cord-018764-02l423mk	212	13	increased	increase	VBN
cord-018764-02l423mk	212	14	ICAM-1	icam-1	NN
cord-018764-02l423mk	212	15	endothelial	endothelial	JJ
cord-018764-02l423mk	212	16	staining	staining	NN
cord-018764-02l423mk	212	17	,	,	,
cord-018764-02l423mk	212	18	reduction	reduction	NN
cord-018764-02l423mk	212	19	in	in	IN
cord-018764-02l423mk	212	20	cell	cell	NN
cord-018764-02l423mk	212	21	junction	junction	NN
cord-018764-02l423mk	212	22	staining	staining	NN
cord-018764-02l423mk	212	23	,	,	,
cord-018764-02l423mk	212	24	and	and	CC
cord-018764-02l423mk	212	25	disruption	disruption	NN
cord-018764-02l423mk	212	26	of	of	IN
cord-018764-02l423mk	212	27	junction	junction	NN
cord-018764-02l423mk	212	28	proteins	protein	NNS
cord-018764-02l423mk	212	29	)	)	-RRB-
cord-018764-02l423mk	212	30	,	,	,
cord-018764-02l423mk	212	31	particularly	particularly	RB
cord-018764-02l423mk	212	32	in	in	IN
cord-018764-02l423mk	212	33	vessels	vessel	NNS
cord-018764-02l423mk	212	34	containing	contain	VBG
cord-018764-02l423mk	212	35	infected	infected	JJ
cord-018764-02l423mk	212	36	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	212	37	[	[	-LRB-
cord-018764-02l423mk	212	38	143	143	CD
cord-018764-02l423mk	212	39	]	]	-RRB-
cord-018764-02l423mk	212	40	.	.	.
cord-018764-02l423mk	213	1	However	however	RB
cord-018764-02l423mk	213	2	,	,	,
cord-018764-02l423mk	213	3	disruption	disruption	NN
cord-018764-02l423mk	213	4	of	of	IN
cord-018764-02l423mk	213	5	intercellular	intercellular	JJ
cord-018764-02l423mk	213	6	junctions	junction	NNS
cord-018764-02l423mk	213	7	is	be	VBZ
cord-018764-02l423mk	213	8	not	not	RB
cord-018764-02l423mk	213	9	associated	associate	VBN
cord-018764-02l423mk	213	10	with	with	IN
cord-018764-02l423mk	213	11	significant	significant	JJ
cord-018764-02l423mk	213	12	leakage	leakage	NN
cord-018764-02l423mk	213	13	of	of	IN
cord-018764-02l423mk	213	14	plasma	plasma	NN
cord-018764-02l423mk	213	15	proteins	protein	NNS
cord-018764-02l423mk	213	16	(	(	-LRB-
cord-018764-02l423mk	213	17	fibrinogen	fibrinogen	NN
cord-018764-02l423mk	213	18	,	,	,
cord-018764-02l423mk	213	19	IgG	IgG	NNP
cord-018764-02l423mk	213	20	,	,	,
cord-018764-02l423mk	213	21	or	or	CC
cord-018764-02l423mk	213	22	C5b-9	c5b-9	XX
cord-018764-02l423mk	213	23	)	)	-RRB-
cord-018764-02l423mk	213	24	into	into	IN
cord-018764-02l423mk	213	25	perivascular	perivascular	JJ
cord-018764-02l423mk	213	26	areas	area	NNS
cord-018764-02l423mk	213	27	or	or	CC
cord-018764-02l423mk	213	28	CSF	CSF	NNP
cord-018764-02l423mk	213	29	[	[	-LRB-
cord-018764-02l423mk	213	30	143	143	CD
cord-018764-02l423mk	213	31	]	]	-RRB-
cord-018764-02l423mk	213	32	.	.	.
cord-018764-02l423mk	214	1	In	in	IN
cord-018764-02l423mk	214	2	Thai	Thai	NNP
cord-018764-02l423mk	214	3	adults	adult	NNS
cord-018764-02l423mk	214	4	,	,	,
cord-018764-02l423mk	214	5	transfer	transfer	NN
cord-018764-02l423mk	214	6	of	of	IN
cord-018764-02l423mk	214	7	radioactively	radioactively	RB
cord-018764-02l423mk	214	8	labelled	label	VBN
cord-018764-02l423mk	214	9	albumin	albumin	NN
cord-018764-02l423mk	214	10	into	into	IN
cord-018764-02l423mk	214	11	CSF	CSF	NNP
cord-018764-02l423mk	214	12	was	be	VBD
cord-018764-02l423mk	214	13	not	not	RB
cord-018764-02l423mk	214	14	raised	raise	VBN
cord-018764-02l423mk	214	15	during	during	IN
cord-018764-02l423mk	214	16	unconsciousness	unconsciousness	NN
cord-018764-02l423mk	214	17	compared	compare	VBN
cord-018764-02l423mk	214	18	with	with	IN
cord-018764-02l423mk	214	19	convalescence	convalescence	NN
cord-018764-02l423mk	214	20	[	[	-LRB-
cord-018764-02l423mk	214	21	144	144	CD
cord-018764-02l423mk	214	22	]	]	-RRB-
cord-018764-02l423mk	214	23	.	.	.
cord-018764-02l423mk	215	1	Similarly	similarly	RB
cord-018764-02l423mk	215	2	,	,	,
cord-018764-02l423mk	215	3	the	the	DT
cord-018764-02l423mk	215	4	albumin	albumin	NN
cord-018764-02l423mk	215	5	index	index	NN
cord-018764-02l423mk	215	6	(	(	-LRB-
cord-018764-02l423mk	215	7	ratio	ratio	NN
cord-018764-02l423mk	215	8	of	of	IN
cord-018764-02l423mk	215	9	concentrations	concentration	NNS
cord-018764-02l423mk	215	10	of	of	IN
cord-018764-02l423mk	215	11	albumin	albumin	NN
cord-018764-02l423mk	215	12	in	in	IN
cord-018764-02l423mk	215	13	CSF	CSF	NNP
cord-018764-02l423mk	215	14	to	to	IN
cord-018764-02l423mk	215	15	those	those	DT
cord-018764-02l423mk	215	16	in	in	IN
cord-018764-02l423mk	215	17	blood	blood	NN
cord-018764-02l423mk	215	18	)	)	-RRB-
cord-018764-02l423mk	215	19	was	be	VBD
cord-018764-02l423mk	215	20	not	not	RB
cord-018764-02l423mk	215	21	altered	alter	VBN
cord-018764-02l423mk	215	22	significantly	significantly	RB
cord-018764-02l423mk	215	23	in	in	IN
cord-018764-02l423mk	215	24	Vietnamese	vietnamese	JJ
cord-018764-02l423mk	215	25	adults	adult	NNS
cord-018764-02l423mk	215	26	[	[	-LRB-
cord-018764-02l423mk	215	27	145	145	CD
cord-018764-02l423mk	215	28	]	]	-RRB-
cord-018764-02l423mk	215	29	or	or	CC
cord-018764-02l423mk	215	30	significantly	significantly	RB
cord-018764-02l423mk	215	31	different	different	JJ
cord-018764-02l423mk	215	32	between	between	IN
cord-018764-02l423mk	215	33	Malawian	malawian	JJ
cord-018764-02l423mk	215	34	children	child	NNS
cord-018764-02l423mk	215	35	with	with	IN
cord-018764-02l423mk	215	36	CM	CM	NNP
cord-018764-02l423mk	215	37	who	who	WP
cord-018764-02l423mk	215	38	died	die	VBD
cord-018764-02l423mk	215	39	and	and	CC
cord-018764-02l423mk	215	40	those	those	DT
cord-018764-02l423mk	215	41	who	who	WP
cord-018764-02l423mk	215	42	survived	survive	VBD
cord-018764-02l423mk	215	43	[	[	-LRB-
cord-018764-02l423mk	215	44	143	143	CD
cord-018764-02l423mk	215	45	]	]	-RRB-
cord-018764-02l423mk	215	46	.	.	.
cord-018764-02l423mk	216	1	Cytotoxic	cytotoxic	JJ
cord-018764-02l423mk	216	2	oedema	oedema	NN
cord-018764-02l423mk	216	3	is	be	VBZ
cord-018764-02l423mk	216	4	increasingly	increasingly	RB
cord-018764-02l423mk	216	5	being	be	VBG
cord-018764-02l423mk	216	6	recognised	recognise	VBN
cord-018764-02l423mk	216	7	as	as	IN
cord-018764-02l423mk	216	8	an	an	DT
cord-018764-02l423mk	216	9	important	important	JJ
cord-018764-02l423mk	216	10	mechanism	mechanism	NN
cord-018764-02l423mk	216	11	of	of	IN
cord-018764-02l423mk	216	12	cerebral	cerebral	JJ
cord-018764-02l423mk	216	13	oedema	oedema	NN
cord-018764-02l423mk	216	14	in	in	IN
cord-018764-02l423mk	216	15	traumatic	traumatic	JJ
cord-018764-02l423mk	216	16	brain	brain	NN
cord-018764-02l423mk	216	17	injury	injury	NN
cord-018764-02l423mk	216	18	[	[	-LRB-
cord-018764-02l423mk	216	19	146	146	CD
cord-018764-02l423mk	216	20	]	]	-RRB-
cord-018764-02l423mk	216	21	.	.	.
cord-018764-02l423mk	217	1	As	as	IN
cord-018764-02l423mk	217	2	previously	previously	RB
cord-018764-02l423mk	217	3	discussed	discuss	VBN
cord-018764-02l423mk	217	4	,	,	,
cord-018764-02l423mk	217	5	this	this	DT
cord-018764-02l423mk	217	6	type	type	NN
cord-018764-02l423mk	217	7	of	of	IN
cord-018764-02l423mk	217	8	cell	cell	NN
cord-018764-02l423mk	217	9	swelling	swelling	NN
cord-018764-02l423mk	217	10	involves	involve	VBZ
cord-018764-02l423mk	217	11	disturbance	disturbance	NN
cord-018764-02l423mk	217	12	of	of	IN
cord-018764-02l423mk	217	13	the	the	DT
cord-018764-02l423mk	217	14	"	"	``
cord-018764-02l423mk	217	15	pumpleak	pumpleak	NNP
cord-018764-02l423mk	217	16	equilibrium	equilibrium	NN
cord-018764-02l423mk	217	17	"	"	''
cord-018764-02l423mk	217	18	maintained	maintain	VBD
cord-018764-02l423mk	217	19	,	,	,
cord-018764-02l423mk	217	20	under	under	IN
cord-018764-02l423mk	217	21	physiological	physiological	JJ
cord-018764-02l423mk	217	22	conditions	condition	NNS
cord-018764-02l423mk	217	23	via	via	IN
cord-018764-02l423mk	217	24	active	active	JJ
cord-018764-02l423mk	217	25	elimination	elimination	NN
cord-018764-02l423mk	217	26	of	of	IN
cord-018764-02l423mk	217	27	osmotically	osmotically	RB
cord-018764-02l423mk	217	28	active	active	JJ
cord-018764-02l423mk	217	29	solutes	solute	NNS
cord-018764-02l423mk	217	30	through	through	IN
cord-018764-02l423mk	217	31	the	the	DT
cord-018764-02l423mk	217	32	energy	energy	NN
cord-018764-02l423mk	217	33	-	-	HYPH
cord-018764-02l423mk	217	34	dependent	dependent	JJ
cord-018764-02l423mk	217	35	Na	Na	NNP
cord-018764-02l423mk	217	36	+	+	CC
cord-018764-02l423mk	217	37	/K	/K	.
cord-018764-02l423mk	218	1	+	+	CC
cord-018764-02l423mk	219	1	-ATPase	-ATPase	NNP
cord-018764-02l423mk	219	2	.	.	.
cord-018764-02l423mk	220	1	Thus	thus	RB
cord-018764-02l423mk	220	2	,	,	,
cord-018764-02l423mk	220	3	cytotoxic	cytotoxic	JJ
cord-018764-02l423mk	220	4	oedema	oedema	NN
cord-018764-02l423mk	220	5	can	can	MD
cord-018764-02l423mk	220	6	occur	occur	VB
cord-018764-02l423mk	220	7	secondary	secondary	JJ
cord-018764-02l423mk	220	8	to	to	IN
cord-018764-02l423mk	220	9	an	an	DT
cord-018764-02l423mk	220	10	imbalance	imbalance	NN
cord-018764-02l423mk	220	11	in	in	IN
cord-018764-02l423mk	220	12	supply	supply	NN
cord-018764-02l423mk	220	13	and	and	CC
cord-018764-02l423mk	220	14	demand	demand	NN
cord-018764-02l423mk	220	15	of	of	IN
cord-018764-02l423mk	220	16	energy	energy	NN
cord-018764-02l423mk	220	17	within	within	IN
cord-018764-02l423mk	220	18	the	the	DT
cord-018764-02l423mk	220	19	cells	cell	NNS
cord-018764-02l423mk	220	20	.	.	.
cord-018764-02l423mk	221	1	Several	several	JJ
cord-018764-02l423mk	221	2	mechanisms	mechanism	NNS
cord-018764-02l423mk	221	3	,	,	,
cord-018764-02l423mk	221	4	such	such	JJ
cord-018764-02l423mk	221	5	as	as	IN
cord-018764-02l423mk	221	6	sustained	sustained	JJ
cord-018764-02l423mk	221	7	increase	increase	NN
cord-018764-02l423mk	221	8	in	in	IN
cord-018764-02l423mk	221	9	neuronal	neuronal	JJ
cord-018764-02l423mk	221	10	activation	activation	NN
cord-018764-02l423mk	221	11	,	,	,
cord-018764-02l423mk	221	12	impaired	impair	VBN
cord-018764-02l423mk	221	13	substrate	substrate	NN
cord-018764-02l423mk	221	14	delivery	delivery	NN
cord-018764-02l423mk	221	15	(	(	-LRB-
cord-018764-02l423mk	221	16	structural	structural	JJ
cord-018764-02l423mk	221	17	and	and	CC
cord-018764-02l423mk	221	18	functional	functional	JJ
cord-018764-02l423mk	221	19	)	)	-RRB-
cord-018764-02l423mk	221	20	and	and	CC
cord-018764-02l423mk	221	21	impaired	impair	VBN
cord-018764-02l423mk	221	22	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	221	23	utilisation	utilisation	NN
cord-018764-02l423mk	221	24	of	of	IN
cord-018764-02l423mk	221	25	available	available	JJ
cord-018764-02l423mk	221	26	substrates	substrate	NNS
cord-018764-02l423mk	221	27	,	,	,
cord-018764-02l423mk	221	28	including	include	VBG
cord-018764-02l423mk	221	29	oxygen	oxygen	NN
cord-018764-02l423mk	221	30	,	,	,
cord-018764-02l423mk	221	31	may	may	MD
cord-018764-02l423mk	221	32	coexist	coexist	VB
cord-018764-02l423mk	221	33	to	to	TO
cord-018764-02l423mk	221	34	generate	generate	VB
cord-018764-02l423mk	221	35	this	this	DT
cord-018764-02l423mk	221	36	imbalance	imbalance	NN
cord-018764-02l423mk	221	37	.	.	.
cord-018764-02l423mk	222	1	All	all	PDT
cord-018764-02l423mk	222	2	these	these	DT
cord-018764-02l423mk	222	3	mechanisms	mechanism	NNS
cord-018764-02l423mk	222	4	could	could	MD
cord-018764-02l423mk	222	5	contribute	contribute	VB
cord-018764-02l423mk	222	6	to	to	IN
cord-018764-02l423mk	222	7	ATP	ATP	NNP
cord-018764-02l423mk	222	8	depletion	depletion	NN
cord-018764-02l423mk	222	9	and	and	CC
cord-018764-02l423mk	222	10	Na	Na	NNP
cord-018764-02l423mk	222	11	+	+	CC
cord-018764-02l423mk	222	12	/K	/k	NN
cord-018764-02l423mk	222	13	+	+	CC
cord-018764-02l423mk	223	1	ATPase	ATPase	NNP
cord-018764-02l423mk	223	2	failure	failure	NN
cord-018764-02l423mk	223	3	,	,	,
cord-018764-02l423mk	223	4	leading	lead	VBG
cord-018764-02l423mk	223	5	to	to	IN
cord-018764-02l423mk	223	6	cytotoxic	cytotoxic	JJ
cord-018764-02l423mk	223	7	oedema	oedema	NN
cord-018764-02l423mk	223	8	in	in	IN
cord-018764-02l423mk	223	9	CM	CM	NNP
cord-018764-02l423mk	223	10	.	.	.
cord-018764-02l423mk	224	1	CM	CM	NNP
cord-018764-02l423mk	224	2	is	be	VBZ
cord-018764-02l423mk	224	3	clearly	clearly	RB
cord-018764-02l423mk	224	4	associated	associate	VBN
cord-018764-02l423mk	224	5	with	with	IN
cord-018764-02l423mk	224	6	increased	increase	VBN
cord-018764-02l423mk	224	7	neuronal	neuronal	JJ
cord-018764-02l423mk	224	8	activity	activity	NN
cord-018764-02l423mk	224	9	.	.	.
cord-018764-02l423mk	225	1	A	a	DT
cord-018764-02l423mk	225	2	recent	recent	JJ
cord-018764-02l423mk	225	3	review	review	NN
cord-018764-02l423mk	225	4	identified	identify	VBD
cord-018764-02l423mk	225	5	that	that	IN
cord-018764-02l423mk	225	6	80	80	CD
cord-018764-02l423mk	225	7	%	%	NN
cord-018764-02l423mk	225	8	of	of	IN
cord-018764-02l423mk	225	9	African	african	JJ
cord-018764-02l423mk	225	10	children	child	NNS
cord-018764-02l423mk	225	11	with	with	IN
cord-018764-02l423mk	225	12	CM	CM	NNP
cord-018764-02l423mk	225	13	have	have	VBP
cord-018764-02l423mk	225	14	a	a	DT
cord-018764-02l423mk	225	15	history	history	NN
cord-018764-02l423mk	225	16	of	of	IN
cord-018764-02l423mk	225	17	seizures	seizure	NNS
cord-018764-02l423mk	225	18	,	,	,
cord-018764-02l423mk	225	19	with	with	IN
cord-018764-02l423mk	225	20	prolonged	prolonged	JJ
cord-018764-02l423mk	225	21	and	and	CC
cord-018764-02l423mk	225	22	recurrent	recurrent	JJ
cord-018764-02l423mk	225	23	seizures	seizure	NNS
cord-018764-02l423mk	225	24	associated	associate	VBN
cord-018764-02l423mk	225	25	with	with	IN
cord-018764-02l423mk	225	26	a	a	DT
cord-018764-02l423mk	225	27	poor	poor	JJ
cord-018764-02l423mk	225	28	outcome	outcome	NN
cord-018764-02l423mk	225	29	[	[	-LRB-
cord-018764-02l423mk	225	30	147	147	CD
cord-018764-02l423mk	225	31	]	]	-RRB-
cord-018764-02l423mk	225	32	.	.	.
cord-018764-02l423mk	226	1	Impaired	impaired	JJ
cord-018764-02l423mk	226	2	vascular	vascular	JJ
cord-018764-02l423mk	226	3	flow	flow	NN
cord-018764-02l423mk	226	4	during	during	IN
cord-018764-02l423mk	226	5	acute	acute	JJ
cord-018764-02l423mk	226	6	CM	cm	NN
cord-018764-02l423mk	226	7	may	may	MD
cord-018764-02l423mk	226	8	limit	limit	VB
cord-018764-02l423mk	226	9	substrate	substrate	NN
cord-018764-02l423mk	226	10	delivery	delivery	NN
cord-018764-02l423mk	226	11	within	within	IN
cord-018764-02l423mk	226	12	the	the	DT
cord-018764-02l423mk	226	13	brain	brain	NN
cord-018764-02l423mk	226	14	and	and	CC
cord-018764-02l423mk	226	15	contribute	contribute	VB
cord-018764-02l423mk	226	16	to	to	IN
cord-018764-02l423mk	226	17	energy	energy	NN
cord-018764-02l423mk	226	18	imbalance	imbalance	NN
cord-018764-02l423mk	226	19	.	.	.
cord-018764-02l423mk	227	1	In	in	IN
cord-018764-02l423mk	227	2	the	the	DT
cord-018764-02l423mk	227	3	past	past	NN
cord-018764-02l423mk	227	4	,	,	,
cord-018764-02l423mk	227	5	a	a	DT
cord-018764-02l423mk	227	6	common	common	JJ
cord-018764-02l423mk	227	7	premise	premise	NN
cord-018764-02l423mk	227	8	was	be	VBD
cord-018764-02l423mk	227	9	that	that	IN
cord-018764-02l423mk	227	10	parasite	parasite	NN
cord-018764-02l423mk	227	11	sequestration	sequestration	NN
cord-018764-02l423mk	227	12	precipitated	precipitate	VBD
cord-018764-02l423mk	227	13	cerebral	cerebral	JJ
cord-018764-02l423mk	227	14	vaso	vaso	JJ
cord-018764-02l423mk	227	15	-	-	HYPH
cord-018764-02l423mk	227	16	occlusive	occlusive	JJ
cord-018764-02l423mk	227	17	/	/	SYM
cord-018764-02l423mk	227	18	ischaemic	ischaemic	JJ
cord-018764-02l423mk	227	19	(	(	-LRB-
cord-018764-02l423mk	227	20	i.e.	i.e.	FW
cord-018764-02l423mk	227	21	stroke	stroke	NN
cord-018764-02l423mk	227	22	-	-	HYPH
cord-018764-02l423mk	227	23	like	like	JJ
cord-018764-02l423mk	227	24	)	)	-RRB-
cord-018764-02l423mk	227	25	events	event	NNS
cord-018764-02l423mk	227	26	that	that	WDT
cord-018764-02l423mk	227	27	manifested	manifest	VBD
cord-018764-02l423mk	227	28	clinically	clinically	RB
cord-018764-02l423mk	227	29	as	as	IN
cord-018764-02l423mk	227	30	CM	CM	NNP
cord-018764-02l423mk	227	31	.	.	.
cord-018764-02l423mk	228	1	However	however	RB
cord-018764-02l423mk	228	2	,	,	,
cord-018764-02l423mk	228	3	CM	CM	NNP
cord-018764-02l423mk	228	4	demonstrates	demonstrate	VBZ
cord-018764-02l423mk	228	5	several	several	JJ
cord-018764-02l423mk	228	6	features	feature	NNS
cord-018764-02l423mk	228	7	that	that	WDT
cord-018764-02l423mk	228	8	are	be	VBP
cord-018764-02l423mk	228	9	atypical	atypical	JJ
cord-018764-02l423mk	228	10	for	for	IN
cord-018764-02l423mk	228	11	stroke	stroke	NN
cord-018764-02l423mk	228	12	.	.	.
cord-018764-02l423mk	229	1	In	in	IN
cord-018764-02l423mk	229	2	children	child	NNS
cord-018764-02l423mk	229	3	,	,	,
cord-018764-02l423mk	229	4	focal	focal	JJ
cord-018764-02l423mk	229	5	neurological	neurological	JJ
cord-018764-02l423mk	229	6	signs	sign	NNS
cord-018764-02l423mk	229	7	do	do	VBP
cord-018764-02l423mk	229	8	not	not	RB
cord-018764-02l423mk	229	9	tend	tend	VB
cord-018764-02l423mk	229	10	to	to	TO
cord-018764-02l423mk	229	11	accompany	accompany	VB
cord-018764-02l423mk	229	12	coma	coma	NN
cord-018764-02l423mk	229	13	,	,	,
cord-018764-02l423mk	229	14	although	although	IN
cord-018764-02l423mk	229	15	a	a	DT
cord-018764-02l423mk	229	16	sub	sub	JJ
cord-018764-02l423mk	229	17	-	-	JJ
cord-018764-02l423mk	229	18	set	set	NN
cord-018764-02l423mk	229	19	of	of	IN
cord-018764-02l423mk	229	20	patients	patient	NNS
cord-018764-02l423mk	229	21	do	do	VBP
cord-018764-02l423mk	229	22	exhibit	exhibit	VB
cord-018764-02l423mk	229	23	hemiparesis	hemiparesis	NN
cord-018764-02l423mk	229	24	or	or	CC
cord-018764-02l423mk	229	25	focal	focal	JJ
cord-018764-02l423mk	229	26	brainstem	brainstem	NN
cord-018764-02l423mk	229	27	deficits	deficit	NNS
cord-018764-02l423mk	229	28	during	during	IN
cord-018764-02l423mk	229	29	the	the	DT
cord-018764-02l423mk	229	30	agonal	agonal	JJ
cord-018764-02l423mk	229	31	period	period	NN
cord-018764-02l423mk	229	32	[	[	-LRB-
cord-018764-02l423mk	229	33	148	148	CD
cord-018764-02l423mk	229	34	]	]	-RRB-
cord-018764-02l423mk	229	35	.	.	.
cord-018764-02l423mk	230	1	The	the	DT
cord-018764-02l423mk	230	2	incidence	incidence	NN
cord-018764-02l423mk	230	3	of	of	IN
cord-018764-02l423mk	230	4	residual	residual	JJ
cord-018764-02l423mk	230	5	neurological	neurological	JJ
cord-018764-02l423mk	230	6	deficits	deficit	NNS
cord-018764-02l423mk	230	7	following	follow	VBG
cord-018764-02l423mk	230	8	recovery	recovery	NN
cord-018764-02l423mk	230	9	from	from	IN
cord-018764-02l423mk	230	10	coma	coma	NN
cord-018764-02l423mk	230	11	is	be	VBZ
cord-018764-02l423mk	230	12	relatively	relatively	RB
cord-018764-02l423mk	230	13	low	low	JJ
cord-018764-02l423mk	230	14	(	(	-LRB-
cord-018764-02l423mk	230	15	11	11	CD
cord-018764-02l423mk	230	16	%	%	NN
cord-018764-02l423mk	230	17	[	[	-LRB-
cord-018764-02l423mk	230	18	147	147	CD
cord-018764-02l423mk	230	19	]	]	-RRB-
cord-018764-02l423mk	230	20	)	)	-RRB-
cord-018764-02l423mk	230	21	when	when	WRB
cord-018764-02l423mk	230	22	compared	compare	VBN
cord-018764-02l423mk	230	23	to	to	IN
cord-018764-02l423mk	230	24	childhood	childhood	NN
cord-018764-02l423mk	230	25	stroke	stroke	NN
cord-018764-02l423mk	230	26	(	(	-LRB-
cord-018764-02l423mk	230	27	93	93	CD
cord-018764-02l423mk	230	28	%	%	NN
cord-018764-02l423mk	230	29	had	have	VBD
cord-018764-02l423mk	230	30	residual	residual	JJ
cord-018764-02l423mk	230	31	neurological	neurological	JJ
cord-018764-02l423mk	230	32	deficit	deficit	NN
cord-018764-02l423mk	230	33	[	[	-LRB-
cord-018764-02l423mk	230	34	149	149	CD
cord-018764-02l423mk	230	35	]	]	-RRB-
cord-018764-02l423mk	230	36	)	)	-RRB-
cord-018764-02l423mk	230	37	.	.	.
cord-018764-02l423mk	231	1	Where	where	WRB
cord-018764-02l423mk	231	2	computer	computer	NN
cord-018764-02l423mk	231	3	tomography	tomography	NN
cord-018764-02l423mk	231	4	has	have	VBZ
cord-018764-02l423mk	231	5	been	be	VBN
cord-018764-02l423mk	231	6	performed	perform	VBN
cord-018764-02l423mk	231	7	in	in	IN
cord-018764-02l423mk	231	8	children	child	NNS
cord-018764-02l423mk	231	9	,	,	,
cord-018764-02l423mk	231	10	diffuse	diffuse	VB
cord-018764-02l423mk	231	11	brain	brain	NN
cord-018764-02l423mk	231	12	swelling	swelling	NN
cord-018764-02l423mk	231	13	was	be	VBD
cord-018764-02l423mk	231	14	observed	observe	VBN
cord-018764-02l423mk	231	15	[	[	-LRB-
cord-018764-02l423mk	231	16	150	150	CD
cord-018764-02l423mk	231	17	]	]	-RRB-
cord-018764-02l423mk	231	18	rather	rather	RB
cord-018764-02l423mk	231	19	than	than	IN
cord-018764-02l423mk	231	20	focal	focal	JJ
cord-018764-02l423mk	231	21	lesions	lesion	NNS
cord-018764-02l423mk	231	22	more	more	RBR
cord-018764-02l423mk	231	23	typical	typical	JJ
cord-018764-02l423mk	231	24	of	of	IN
cord-018764-02l423mk	231	25	stroke	stroke	NN
cord-018764-02l423mk	231	26	.	.	.
cord-018764-02l423mk	232	1	Although	although	IN
cord-018764-02l423mk	232	2	retinal	retinal	JJ
cord-018764-02l423mk	232	3	haemorrhages	haemorrhage	NNS
cord-018764-02l423mk	232	4	have	have	VBP
cord-018764-02l423mk	232	5	been	be	VBN
cord-018764-02l423mk	232	6	observed	observe	VBN
cord-018764-02l423mk	232	7	in	in	IN
cord-018764-02l423mk	232	8	46	46	CD
cord-018764-02l423mk	232	9	%	%	NN
cord-018764-02l423mk	232	10	of	of	IN
cord-018764-02l423mk	232	11	Malawian	malawian	JJ
cord-018764-02l423mk	232	12	children	child	NNS
cord-018764-02l423mk	232	13	with	with	IN
cord-018764-02l423mk	232	14	CM	CM	NNP
cord-018764-02l423mk	232	15	(	(	-LRB-
cord-018764-02l423mk	232	16	and	and	CC
cord-018764-02l423mk	232	17	in	in	IN
cord-018764-02l423mk	232	18	63	63	CD
cord-018764-02l423mk	232	19	%	%	NN
cord-018764-02l423mk	232	20	of	of	IN
cord-018764-02l423mk	232	21	patients	patient	NNS
cord-018764-02l423mk	232	22	who	who	WP
cord-018764-02l423mk	232	23	died	die	VBD
cord-018764-02l423mk	232	24	)	)	-RRB-
cord-018764-02l423mk	232	25	,	,	,
cord-018764-02l423mk	232	26	these	these	DT
cord-018764-02l423mk	232	27	lesions	lesion	NNS
cord-018764-02l423mk	232	28	were	be	VBD
cord-018764-02l423mk	232	29	also	also	RB
cord-018764-02l423mk	232	30	seen	see	VBN
cord-018764-02l423mk	232	31	in	in	IN
cord-018764-02l423mk	232	32	30	30	CD
cord-018764-02l423mk	232	33	%	%	NN
cord-018764-02l423mk	232	34	of	of	IN
cord-018764-02l423mk	232	35	children	child	NNS
cord-018764-02l423mk	232	36	with	with	IN
cord-018764-02l423mk	232	37	SMA	SMA	NNP
cord-018764-02l423mk	232	38	in	in	IN
cord-018764-02l423mk	232	39	the	the	DT
cord-018764-02l423mk	232	40	same	same	JJ
cord-018764-02l423mk	232	41	study	study	NN
cord-018764-02l423mk	232	42	[	[	-LRB-
cord-018764-02l423mk	232	43	140	140	CD
cord-018764-02l423mk	232	44	]	]	-RRB-
cord-018764-02l423mk	232	45	.	.	.
cord-018764-02l423mk	233	1	Consequently	consequently	RB
cord-018764-02l423mk	233	2	,	,	,
cord-018764-02l423mk	233	3	although	although	IN
cord-018764-02l423mk	233	4	associated	associate	VBN
cord-018764-02l423mk	233	5	with	with	IN
cord-018764-02l423mk	233	6	CM	CM	NNP
cord-018764-02l423mk	233	7	,	,	,
cord-018764-02l423mk	233	8	retinal	retinal	JJ
cord-018764-02l423mk	233	9	haemorrhages	haemorrhage	NNS
cord-018764-02l423mk	233	10	do	do	VBP
cord-018764-02l423mk	233	11	not	not	RB
cord-018764-02l423mk	233	12	confirm	confirm	VB
cord-018764-02l423mk	233	13	that	that	IN
cord-018764-02l423mk	233	14	focal	focal	JJ
cord-018764-02l423mk	233	15	cerebral	cerebral	JJ
cord-018764-02l423mk	233	16	vaso	vaso	JJ
cord-018764-02l423mk	233	17	-	-	HYPH
cord-018764-02l423mk	233	18	occlusive	occlusive	JJ
cord-018764-02l423mk	233	19	/	/	SYM
cord-018764-02l423mk	233	20	ischaemic	ischaemic	JJ
cord-018764-02l423mk	233	21	events	event	NNS
cord-018764-02l423mk	233	22	underlie	underlie	VBP
cord-018764-02l423mk	233	23	CM	CM	NNP
cord-018764-02l423mk	233	24	.	.	.
cord-018764-02l423mk	234	1	Similarly	similarly	RB
cord-018764-02l423mk	234	2	,	,	,
cord-018764-02l423mk	234	3	histological	histological	JJ
cord-018764-02l423mk	234	4	examination	examination	NN
cord-018764-02l423mk	234	5	of	of	IN
cord-018764-02l423mk	234	6	32	32	CD
cord-018764-02l423mk	234	7	fatal	fatal	JJ
cord-018764-02l423mk	234	8	CM	cm	NN
cord-018764-02l423mk	234	9	cases	case	NNS
cord-018764-02l423mk	234	10	of	of	IN
cord-018764-02l423mk	234	11	African	african	JJ
cord-018764-02l423mk	234	12	children	child	NNS
cord-018764-02l423mk	234	13	at	at	IN
cord-018764-02l423mk	234	14	autopsy	autopsy	NN
cord-018764-02l423mk	234	15	demonstrated	demonstrate	VBD
cord-018764-02l423mk	234	16	that	that	IN
cord-018764-02l423mk	234	17	one	one	CD
cord-018764-02l423mk	234	18	third	third	RB
cord-018764-02l423mk	234	19	had	have	VBD
cord-018764-02l423mk	234	20	little	little	JJ
cord-018764-02l423mk	234	21	or	or	CC
cord-018764-02l423mk	234	22	no	no	DT
cord-018764-02l423mk	234	23	evidence	evidence	NN
cord-018764-02l423mk	234	24	of	of	IN
cord-018764-02l423mk	234	25	local	local	JJ
cord-018764-02l423mk	234	26	vascular	vascular	JJ
cord-018764-02l423mk	234	27	change	change	NN
cord-018764-02l423mk	234	28	in	in	IN
cord-018764-02l423mk	234	29	the	the	DT
cord-018764-02l423mk	234	30	brain	brain	NN
cord-018764-02l423mk	234	31	,	,	,
cord-018764-02l423mk	234	32	as	as	IN
cord-018764-02l423mk	234	33	indicated	indicate	VBN
cord-018764-02l423mk	234	34	by	by	IN
cord-018764-02l423mk	234	35	sequestered	sequester	VBN
cord-018764-02l423mk	234	36	parasites	parasite	NNS
cord-018764-02l423mk	234	37	,	,	,
cord-018764-02l423mk	234	38	monocyte	monocyte	NNP
cord-018764-02l423mk	234	39	clusters	cluster	NNS
cord-018764-02l423mk	234	40	,	,	,
cord-018764-02l423mk	234	41	micro	micro	NNS
cord-018764-02l423mk	234	42	-	-	NNS
cord-018764-02l423mk	234	43	haemorrhages	haemorrhage	NNS
cord-018764-02l423mk	234	44	,	,	,
cord-018764-02l423mk	234	45	local	local	JJ
cord-018764-02l423mk	234	46	vascular	vascular	JJ
cord-018764-02l423mk	234	47	iNOS	inos	XX
cord-018764-02l423mk	234	48	[	[	-LRB-
cord-018764-02l423mk	234	49	151	151	CD
cord-018764-02l423mk	234	50	]	]	-RRB-
cord-018764-02l423mk	234	51	or	or	CC
cord-018764-02l423mk	234	52	haemoxygenase	haemoxygenase	NNP
cord-018764-02l423mk	234	53	-1	-1	.
cord-018764-02l423mk	235	1	(	(	-LRB-
cord-018764-02l423mk	235	2	HO-1	HO-1	NNP
cord-018764-02l423mk	235	3	)	)	-RRB-
cord-018764-02l423mk	236	1	[	[	-LRB-
cord-018764-02l423mk	236	2	152	152	CD
cord-018764-02l423mk	236	3	]	]	-RRB-
cord-018764-02l423mk	236	4	staining	staining	NN
cord-018764-02l423mk	236	5	.	.	.
cord-018764-02l423mk	237	1	Accepting	accept	VBG
cord-018764-02l423mk	237	2	that	that	IN
cord-018764-02l423mk	237	3	CM	CM	NNP
cord-018764-02l423mk	237	4	may	may	MD
cord-018764-02l423mk	237	5	occur	occur	VB
cord-018764-02l423mk	237	6	without	without	IN
cord-018764-02l423mk	237	7	ischaemia	ischaemia	NN
cord-018764-02l423mk	237	8	does	do	VBZ
cord-018764-02l423mk	237	9	not	not	RB
cord-018764-02l423mk	237	10	exclude	exclude	VB
cord-018764-02l423mk	237	11	temporary	temporary	JJ
cord-018764-02l423mk	237	12	or	or	CC
cord-018764-02l423mk	237	13	less	less	RBR
cord-018764-02l423mk	237	14	severe	severe	JJ
cord-018764-02l423mk	237	15	reductions	reduction	NNS
cord-018764-02l423mk	237	16	in	in	IN
cord-018764-02l423mk	237	17	vessel	vessel	NN
cord-018764-02l423mk	237	18	flow	flow	NN
cord-018764-02l423mk	237	19	occurring	occur	VBG
cord-018764-02l423mk	237	20	during	during	IN
cord-018764-02l423mk	237	21	acute	acute	JJ
cord-018764-02l423mk	237	22	CM	cm	NN
cord-018764-02l423mk	237	23	(	(	-LRB-
cord-018764-02l423mk	237	24	associated	associated	JJ
cord-018764-02l423mk	237	25	or	or	CC
cord-018764-02l423mk	237	26	independent	independent	JJ
cord-018764-02l423mk	237	27	of	of	IN
cord-018764-02l423mk	237	28	parasite	parasite	NN
cord-018764-02l423mk	237	29	sequestration	sequestration	NN
cord-018764-02l423mk	237	30	)	)	-RRB-
cord-018764-02l423mk	237	31	that	that	WDT
cord-018764-02l423mk	237	32	may	may	MD
cord-018764-02l423mk	237	33	contribute	contribute	VB
cord-018764-02l423mk	237	34	to	to	IN
cord-018764-02l423mk	237	35	impaired	impair	VBN
cord-018764-02l423mk	237	36	substrate	substrate	NN
cord-018764-02l423mk	237	37	delivery	delivery	NN
cord-018764-02l423mk	237	38	and	and	CC
cord-018764-02l423mk	237	39	lead	lead	VB
cord-018764-02l423mk	237	40	to	to	IN
cord-018764-02l423mk	237	41	energy	energy	NN
cord-018764-02l423mk	237	42	imbalance	imbalance	NN
cord-018764-02l423mk	237	43	.	.	.
cord-018764-02l423mk	238	1	As	as	IN
cord-018764-02l423mk	238	2	previously	previously	RB
cord-018764-02l423mk	238	3	discussed	discuss	VBN
cord-018764-02l423mk	238	4	,	,	,
cord-018764-02l423mk	238	5	energy	energy	NN
cord-018764-02l423mk	238	6	imbalance	imbalance	NN
cord-018764-02l423mk	238	7	may	may	MD
cord-018764-02l423mk	238	8	also	also	RB
cord-018764-02l423mk	238	9	be	be	VB
cord-018764-02l423mk	238	10	impaired	impair	VBN
cord-018764-02l423mk	238	11	due	due	IN
cord-018764-02l423mk	238	12	to	to	IN
cord-018764-02l423mk	238	13	the	the	DT
cord-018764-02l423mk	238	14	uncoupling	uncoupling	JJ
cord-018764-02l423mk	238	15	action	action	NN
cord-018764-02l423mk	238	16	of	of	IN
cord-018764-02l423mk	238	17	inflammatory	inflammatory	JJ
cord-018764-02l423mk	238	18	cytokines	cytokine	NNS
cord-018764-02l423mk	238	19	on	on	IN
cord-018764-02l423mk	238	20	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	238	21	ATP	ATP	NNP
cord-018764-02l423mk	238	22	production	production	NN
cord-018764-02l423mk	238	23	.	.	.
cord-018764-02l423mk	239	1	In	in	IN
cord-018764-02l423mk	239	2	Gambian	gambian	JJ
cord-018764-02l423mk	239	3	and	and	CC
cord-018764-02l423mk	239	4	Ghanaian	ghanaian	JJ
cord-018764-02l423mk	239	5	children	child	NNS
cord-018764-02l423mk	239	6	,	,	,
cord-018764-02l423mk	239	7	concentrations	concentration	NNS
cord-018764-02l423mk	239	8	of	of	IN
cord-018764-02l423mk	239	9	TNF	TNF	NNP
cord-018764-02l423mk	239	10	and	and	CC
cord-018764-02l423mk	239	11	its	-PRON-	PRP$
cord-018764-02l423mk	239	12	receptor	receptor	NN
cord-018764-02l423mk	239	13	were	be	VBD
cord-018764-02l423mk	239	14	higher	high	JJR
cord-018764-02l423mk	239	15	in	in	IN
cord-018764-02l423mk	239	16	those	those	DT
cord-018764-02l423mk	239	17	with	with	IN
cord-018764-02l423mk	239	18	CM	CM	NNP
cord-018764-02l423mk	239	19	than	than	IN
cord-018764-02l423mk	239	20	in	in	IN
cord-018764-02l423mk	239	21	those	those	DT
cord-018764-02l423mk	239	22	with	with	IN
cord-018764-02l423mk	239	23	mild	mild	JJ
cord-018764-02l423mk	239	24	or	or	CC
cord-018764-02l423mk	239	25	uncomplicated	uncomplicated	JJ
cord-018764-02l423mk	239	26	malaria	malaria	NN
cord-018764-02l423mk	239	27	[	[	-LRB-
cord-018764-02l423mk	239	28	153	153	CD
cord-018764-02l423mk	239	29	,	,	,
cord-018764-02l423mk	239	30	154	154	CD
cord-018764-02l423mk	239	31	]	]	-RRB-
cord-018764-02l423mk	239	32	.	.	.
cord-018764-02l423mk	240	1	Polymorphisms	polymorphism	NNS
cord-018764-02l423mk	240	2	in	in	IN
cord-018764-02l423mk	240	3	the	the	DT
cord-018764-02l423mk	240	4	TNF	TNF	NNP
cord-018764-02l423mk	240	5	promoter	promoter	NN
cord-018764-02l423mk	240	6	region	region	NN
cord-018764-02l423mk	240	7	have	have	VBP
cord-018764-02l423mk	240	8	also	also	RB
cord-018764-02l423mk	240	9	been	be	VBN
cord-018764-02l423mk	240	10	associated	associate	VBN
cord-018764-02l423mk	240	11	with	with	IN
cord-018764-02l423mk	240	12	increased	increase	VBN
cord-018764-02l423mk	240	13	risk	risk	NN
cord-018764-02l423mk	240	14	of	of	IN
cord-018764-02l423mk	240	15	CM	cm	NN
cord-018764-02l423mk	240	16	and	and	CC
cord-018764-02l423mk	240	17	death	death	NN
cord-018764-02l423mk	240	18	[	[	-LRB-
cord-018764-02l423mk	240	19	155	155	CD
cord-018764-02l423mk	240	20	]	]	-RRB-
cord-018764-02l423mk	240	21	or	or	CC
cord-018764-02l423mk	240	22	neurological	neurological	JJ
cord-018764-02l423mk	240	23	sequelae	sequela	NNS
cord-018764-02l423mk	240	24	[	[	-LRB-
cord-018764-02l423mk	240	25	156	156	CD
cord-018764-02l423mk	240	26	]	]	-RRB-
cord-018764-02l423mk	240	27	.	.	.
cord-018764-02l423mk	241	1	Cytokines	cytokine	NNS
cord-018764-02l423mk	241	2	may	may	MD
cord-018764-02l423mk	241	3	also	also	RB
cord-018764-02l423mk	241	4	up	up	RB
cord-018764-02l423mk	241	5	-	-	HYPH
cord-018764-02l423mk	241	6	regulate	regulate	VB
cord-018764-02l423mk	241	7	iNOS	inos	NN
cord-018764-02l423mk	241	8	in	in	IN
cord-018764-02l423mk	241	9	brain	brain	NN
cord-018764-02l423mk	241	10	endothelial	endothelial	NN
cord-018764-02l423mk	241	11	cells	cell	NNS
cord-018764-02l423mk	241	12	,	,	,
cord-018764-02l423mk	241	13	increasing	increase	VBG
cord-018764-02l423mk	241	14	production	production	NN
cord-018764-02l423mk	241	15	of	of	IN
cord-018764-02l423mk	241	16	NO	no	NN
cord-018764-02l423mk	241	17	,	,	,
cord-018764-02l423mk	241	18	which	which	WDT
cord-018764-02l423mk	241	19	could	could	MD
cord-018764-02l423mk	241	20	then	then	RB
cord-018764-02l423mk	241	21	diffuse	diffuse	VB
cord-018764-02l423mk	241	22	into	into	IN
cord-018764-02l423mk	241	23	brain	brain	NN
cord-018764-02l423mk	241	24	tissue	tissue	NN
cord-018764-02l423mk	241	25	and	and	CC
cord-018764-02l423mk	241	26	disrupt	disrupt	VB
cord-018764-02l423mk	241	27	neuronal	neuronal	JJ
cord-018764-02l423mk	241	28	(	(	-LRB-
cord-018764-02l423mk	241	29	and/or	and/or	CC
cord-018764-02l423mk	241	30	mitochondrial	mitochondrial	NN
cord-018764-02l423mk	241	31	)	)	-RRB-
cord-018764-02l423mk	241	32	function	function	NN
cord-018764-02l423mk	241	33	[	[	-LRB-
cord-018764-02l423mk	241	34	157	157	CD
cord-018764-02l423mk	241	35	,	,	,
cord-018764-02l423mk	241	36	158	158	CD
cord-018764-02l423mk	241	37	]	]	-RRB-
cord-018764-02l423mk	241	38	.	.	.
cord-018764-02l423mk	242	1	In	in	IN
cord-018764-02l423mk	242	2	the	the	DT
cord-018764-02l423mk	242	3	brain	brain	NN
cord-018764-02l423mk	242	4	,	,	,
cord-018764-02l423mk	242	5	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	242	6	function	function	NN
cord-018764-02l423mk	242	7	may	may	MD
cord-018764-02l423mk	242	8	also	also	RB
cord-018764-02l423mk	242	9	be	be	VB
cord-018764-02l423mk	242	10	influenced	influence	VBN
cord-018764-02l423mk	242	11	by	by	IN
cord-018764-02l423mk	242	12	neuronal	neuronal	JJ
cord-018764-02l423mk	242	13	excitotoxins	excitotoxin	NNS
cord-018764-02l423mk	242	14	.	.	.
cord-018764-02l423mk	243	1	Within	within	IN
cord-018764-02l423mk	243	2	the	the	DT
cord-018764-02l423mk	243	3	simplified	simplified	JJ
cord-018764-02l423mk	243	4	model	model	NN
cord-018764-02l423mk	243	5	of	of	IN
cord-018764-02l423mk	243	6	dissociated	dissociated	JJ
cord-018764-02l423mk	243	7	neuronal	neuronal	JJ
cord-018764-02l423mk	243	8	culture	culture	NN
cord-018764-02l423mk	243	9	,	,	,
cord-018764-02l423mk	243	10	mitochondria	mitochondrion	NNS
cord-018764-02l423mk	243	11	appear	appear	VBP
cord-018764-02l423mk	243	12	to	to	TO
cord-018764-02l423mk	243	13	play	play	VB
cord-018764-02l423mk	243	14	a	a	DT
cord-018764-02l423mk	243	15	critical	critical	JJ
cord-018764-02l423mk	243	16	role	role	NN
cord-018764-02l423mk	243	17	in	in	IN
cord-018764-02l423mk	243	18	neuronal	neuronal	JJ
cord-018764-02l423mk	243	19	homeostasis	homeostasis	NN
cord-018764-02l423mk	243	20	during	during	IN
cord-018764-02l423mk	243	21	excitotoxin	excitotoxin	NN
cord-018764-02l423mk	243	22	exposure	exposure	NN
cord-018764-02l423mk	243	23	.	.	.
cord-018764-02l423mk	244	1	Mitochondria	mitochondrion	NNS
cord-018764-02l423mk	244	2	are	be	VBP
cord-018764-02l423mk	244	3	not	not	RB
cord-018764-02l423mk	244	4	only	only	RB
cord-018764-02l423mk	244	5	involved	involve	VBN
cord-018764-02l423mk	244	6	with	with	IN
cord-018764-02l423mk	244	7	maintaining	maintain	VBG
cord-018764-02l423mk	244	8	ATP	ATP	NNP
cord-018764-02l423mk	244	9	production	production	NN
cord-018764-02l423mk	244	10	but	but	CC
cord-018764-02l423mk	244	11	also	also	RB
cord-018764-02l423mk	244	12	calcium	calcium	VBP
cord-018764-02l423mk	244	13	homeostasis	homeostasis	NN
cord-018764-02l423mk	244	14	,	,	,
cord-018764-02l423mk	244	15	and	and	CC
cord-018764-02l423mk	244	16	generation	generation	NN
cord-018764-02l423mk	244	17	and	and	CC
cord-018764-02l423mk	244	18	detoxification	detoxification	NN
cord-018764-02l423mk	244	19	of	of	IN
cord-018764-02l423mk	244	20	reactive	reactive	JJ
cord-018764-02l423mk	244	21	oxygen	oxygen	NN
cord-018764-02l423mk	244	22	species	specie	NNS
cord-018764-02l423mk	244	23	[	[	-LRB-
cord-018764-02l423mk	244	24	107	107	CD
cord-018764-02l423mk	244	25	]	]	-RRB-
cord-018764-02l423mk	244	26	.	.	.
cord-018764-02l423mk	245	1	Excitotoxin	excitotoxin	JJ
cord-018764-02l423mk	245	2	production	production	NN
cord-018764-02l423mk	245	3	may	may	MD
cord-018764-02l423mk	245	4	also	also	RB
cord-018764-02l423mk	245	5	be	be	VB
cord-018764-02l423mk	245	6	influenced	influence	VBN
cord-018764-02l423mk	245	7	by	by	IN
cord-018764-02l423mk	245	8	cytokine	cytokine	NN
cord-018764-02l423mk	245	9	release	release	NN
cord-018764-02l423mk	245	10	.	.	.
cord-018764-02l423mk	246	1	TNF	TNF	NNP
cord-018764-02l423mk	246	2	administration	administration	NN
cord-018764-02l423mk	246	3	has	have	VBZ
cord-018764-02l423mk	246	4	been	be	VBN
cord-018764-02l423mk	246	5	shown	show	VBN
cord-018764-02l423mk	246	6	to	to	TO
cord-018764-02l423mk	246	7	alter	alter	VB
cord-018764-02l423mk	246	8	brain	brain	NN
cord-018764-02l423mk	246	9	metabolism	metabolism	NN
cord-018764-02l423mk	246	10	of	of	IN
cord-018764-02l423mk	246	11	tryptophan	tryptophan	NN
cord-018764-02l423mk	246	12	to	to	TO
cord-018764-02l423mk	246	13	produce	produce	VB
cord-018764-02l423mk	246	14	more	more	JJR
cord-018764-02l423mk	246	15	kynurinine	kynurinine	NNP
cord-018764-02l423mk	246	16	[	[	-LRB-
cord-018764-02l423mk	246	17	159	159	CD
cord-018764-02l423mk	246	18	,	,	,
cord-018764-02l423mk	246	19	160	160	CD
cord-018764-02l423mk	246	20	]	]	-RRB-
cord-018764-02l423mk	246	21	.	.	.
cord-018764-02l423mk	247	1	Thus	thus	RB
cord-018764-02l423mk	247	2	,	,	,
cord-018764-02l423mk	247	3	as	as	IN
cord-018764-02l423mk	247	4	part	part	NN
cord-018764-02l423mk	247	5	of	of	IN
cord-018764-02l423mk	247	6	a	a	DT
cord-018764-02l423mk	247	7	general	general	JJ
cord-018764-02l423mk	247	8	inflammatory	inflammatory	JJ
cord-018764-02l423mk	247	9	reaction	reaction	NN
cord-018764-02l423mk	247	10	,	,	,
cord-018764-02l423mk	247	11	increased	increase	VBN
cord-018764-02l423mk	247	12	excitotoxin	excitotoxin	NN
cord-018764-02l423mk	247	13	generation	generation	NN
cord-018764-02l423mk	247	14	during	during	IN
cord-018764-02l423mk	247	15	acute	acute	JJ
cord-018764-02l423mk	247	16	malaria	malaria	NN
cord-018764-02l423mk	247	17	may	may	MD
cord-018764-02l423mk	247	18	contribute	contribute	VB
cord-018764-02l423mk	247	19	to	to	IN
cord-018764-02l423mk	247	20	cellular	cellular	JJ
cord-018764-02l423mk	247	21	energy	energy	NN
cord-018764-02l423mk	247	22	imbalance	imbalance	NN
cord-018764-02l423mk	247	23	.	.	.
cord-018764-02l423mk	248	1	Elevated	elevated	JJ
cord-018764-02l423mk	248	2	levels	level	NNS
cord-018764-02l423mk	248	3	of	of	IN
cord-018764-02l423mk	248	4	neuronal	neuronal	JJ
cord-018764-02l423mk	248	5	excitotoxins	excitotoxin	NNS
cord-018764-02l423mk	248	6	(	(	-LRB-
cord-018764-02l423mk	248	7	quinolinic	quinolinic	NNP
cord-018764-02l423mk	248	8	and	and	CC
cord-018764-02l423mk	248	9	picolinic	picolinic	NNP
cord-018764-02l423mk	248	10	acid	acid	NN
cord-018764-02l423mk	248	11	)	)	-RRB-
cord-018764-02l423mk	248	12	in	in	IN
cord-018764-02l423mk	248	13	the	the	DT
cord-018764-02l423mk	248	14	CSF	CSF	NNP
cord-018764-02l423mk	248	15	have	have	VBP
cord-018764-02l423mk	248	16	been	be	VBN
cord-018764-02l423mk	248	17	associated	associate	VBN
cord-018764-02l423mk	248	18	with	with	IN
cord-018764-02l423mk	248	19	a	a	DT
cord-018764-02l423mk	248	20	fatal	fatal	JJ
cord-018764-02l423mk	248	21	outcome	outcome	NN
cord-018764-02l423mk	248	22	in	in	IN
cord-018764-02l423mk	248	23	Malawian	malawian	JJ
cord-018764-02l423mk	248	24	children	child	NNS
cord-018764-02l423mk	248	25	with	with	IN
cord-018764-02l423mk	248	26	CM	CM	NNP
cord-018764-02l423mk	248	27	[	[	-LRB-
cord-018764-02l423mk	248	28	161	161	CD
cord-018764-02l423mk	248	29	]	]	-RRB-
cord-018764-02l423mk	248	30	.	.	.
cord-018764-02l423mk	249	1	Similarly	similarly	RB
cord-018764-02l423mk	249	2	,	,	,
cord-018764-02l423mk	249	3	a	a	DT
cord-018764-02l423mk	249	4	graded	grade	VBN
cord-018764-02l423mk	249	5	increment	increment	NN
cord-018764-02l423mk	249	6	of	of	IN
cord-018764-02l423mk	249	7	quinolinic	quinolinic	JJ
cord-018764-02l423mk	249	8	acid	acid	JJ
cord-018764-02l423mk	249	9	concentration	concentration	NN
cord-018764-02l423mk	249	10	in	in	IN
cord-018764-02l423mk	249	11	CSF	CSF	NNP
cord-018764-02l423mk	249	12	was	be	VBD
cord-018764-02l423mk	249	13	observed	observe	VBN
cord-018764-02l423mk	249	14	across	across	IN
cord-018764-02l423mk	249	15	patient	patient	JJ
cord-018764-02l423mk	249	16	outcome	outcome	NN
cord-018764-02l423mk	249	17	groups	group	NNS
cord-018764-02l423mk	249	18	of	of	IN
cord-018764-02l423mk	249	19	increasing	increase	VBG
cord-018764-02l423mk	249	20	severity	severity	NN
cord-018764-02l423mk	249	21	in	in	IN
cord-018764-02l423mk	249	22	African	african	JJ
cord-018764-02l423mk	249	23	children	child	NNS
cord-018764-02l423mk	249	24	[	[	-LRB-
cord-018764-02l423mk	249	25	162	162	CD
cord-018764-02l423mk	249	26	]	]	-RRB-
cord-018764-02l423mk	249	27	.	.	.
cord-018764-02l423mk	250	1	Although	although	IN
cord-018764-02l423mk	250	2	a	a	DT
cord-018764-02l423mk	250	3	subset	subset	NN
cord-018764-02l423mk	250	4	of	of	IN
cord-018764-02l423mk	250	5	the	the	DT
cord-018764-02l423mk	250	6	Malawaian	malawaian	JJ
cord-018764-02l423mk	250	7	autopsy	autopsy	JJ
cord-018764-02l423mk	250	8	patients	patient	NNS
cord-018764-02l423mk	250	9	[	[	-LRB-
cord-018764-02l423mk	250	10	163	163	CD
cord-018764-02l423mk	250	11	]	]	-RRB-
cord-018764-02l423mk	250	12	demonstrated	demonstrate	VBN
cord-018764-02l423mk	250	13	negligible	negligible	JJ
cord-018764-02l423mk	250	14	histological	histological	JJ
cord-018764-02l423mk	250	15	change	change	NN
cord-018764-02l423mk	250	16	in	in	IN
cord-018764-02l423mk	250	17	their	-PRON-	PRP$
cord-018764-02l423mk	250	18	brains	brain	NNS
cord-018764-02l423mk	250	19	,	,	,
cord-018764-02l423mk	250	20	they	-PRON-	PRP
cord-018764-02l423mk	250	21	did	do	VBD
cord-018764-02l423mk	250	22	demonstrate	demonstrate	VB
cord-018764-02l423mk	250	23	inflammation	inflammation	NN
cord-018764-02l423mk	250	24	,	,	,
cord-018764-02l423mk	250	25	as	as	IN
cord-018764-02l423mk	250	26	indicated	indicate	VBN
cord-018764-02l423mk	250	27	by	by	IN
cord-018764-02l423mk	251	1	iNOS	iNOS	NNP
cord-018764-02l423mk	251	2	,	,	,
cord-018764-02l423mk	251	3	MIF	MIF	NNP
cord-018764-02l423mk	251	4	[	[	-LRB-
cord-018764-02l423mk	251	5	151	151	CD
cord-018764-02l423mk	251	6	]	]	-RRB-
cord-018764-02l423mk	251	7	and	and	CC
cord-018764-02l423mk	251	8	HO-1	HO-1	NNP
cord-018764-02l423mk	251	9	[	[	-LRB-
cord-018764-02l423mk	251	10	152	152	CD
cord-018764-02l423mk	251	11	]	]	-RRB-
cord-018764-02l423mk	251	12	,	,	,
cord-018764-02l423mk	251	13	staining	stain	VBG
cord-018764-02l423mk	251	14	in	in	IN
cord-018764-02l423mk	251	15	other	other	JJ
cord-018764-02l423mk	251	16	tissues	tissue	NNS
cord-018764-02l423mk	251	17	.	.	.
cord-018764-02l423mk	252	1	These	these	DT
cord-018764-02l423mk	252	2	systemic	systemic	JJ
cord-018764-02l423mk	252	3	changes	change	NNS
cord-018764-02l423mk	252	4	were	be	VBD
cord-018764-02l423mk	252	5	shared	share	VBN
cord-018764-02l423mk	252	6	with	with	IN
cord-018764-02l423mk	252	7	the	the	DT
cord-018764-02l423mk	252	8	comatose	comatose	JJ
cord-018764-02l423mk	252	9	sepsis	sepsis	NN
cord-018764-02l423mk	252	10	cases	case	NNS
cord-018764-02l423mk	252	11	in	in	IN
cord-018764-02l423mk	252	12	the	the	DT
cord-018764-02l423mk	252	13	study	study	NN
cord-018764-02l423mk	252	14	,	,	,
cord-018764-02l423mk	252	15	and	and	CC
cord-018764-02l423mk	252	16	therefore	therefore	RB
cord-018764-02l423mk	252	17	are	be	VBP
cord-018764-02l423mk	252	18	consistent	consistent	JJ
cord-018764-02l423mk	252	19	with	with	IN
cord-018764-02l423mk	252	20	the	the	DT
cord-018764-02l423mk	252	21	premise	premise	NN
cord-018764-02l423mk	252	22	that	that	IN
cord-018764-02l423mk	252	23	coma	coma	NN
cord-018764-02l423mk	252	24	may	may	MD
cord-018764-02l423mk	252	25	in	in	IN
cord-018764-02l423mk	252	26	part	part	NN
cord-018764-02l423mk	252	27	be	be	VB
cord-018764-02l423mk	252	28	secondary	secondary	JJ
cord-018764-02l423mk	252	29	to	to	IN
cord-018764-02l423mk	252	30	a	a	DT
cord-018764-02l423mk	252	31	host	host	NN
cord-018764-02l423mk	252	32	inflammatory	inflammatory	JJ
cord-018764-02l423mk	252	33	response	response	NN
cord-018764-02l423mk	252	34	to	to	IN
cord-018764-02l423mk	252	35	systemic	systemic	JJ
cord-018764-02l423mk	252	36	infection	infection	NN
cord-018764-02l423mk	252	37	.	.	.
cord-018764-02l423mk	253	1	Below	below	RB
cord-018764-02l423mk	253	2	are	be	VBP
cord-018764-02l423mk	253	3	further	further	JJ
cord-018764-02l423mk	253	4	examples	example	NNS
cord-018764-02l423mk	253	5	of	of	IN
cord-018764-02l423mk	253	6	systemic	systemic	JJ
cord-018764-02l423mk	253	7	responses	response	NNS
cord-018764-02l423mk	253	8	to	to	IN
cord-018764-02l423mk	253	9	infection	infection	NN
cord-018764-02l423mk	253	10	that	that	WDT
cord-018764-02l423mk	253	11	present	present	JJ
cord-018764-02l423mk	253	12	with	with	IN
cord-018764-02l423mk	253	13	diffuse	diffuse	JJ
cord-018764-02l423mk	253	14	cerebral	cerebral	JJ
cord-018764-02l423mk	253	15	syndromes	syndrome	NNS
cord-018764-02l423mk	253	16	,	,	,
cord-018764-02l423mk	253	17	including	include	VBG
cord-018764-02l423mk	253	18	coma	coma	NN
cord-018764-02l423mk	253	19	.	.	.
cord-018764-02l423mk	254	1	In	in	IN
cord-018764-02l423mk	254	2	the	the	DT
cord-018764-02l423mk	254	3	past	past	NN
cord-018764-02l423mk	254	4	,	,	,
cord-018764-02l423mk	254	5	the	the	DT
cord-018764-02l423mk	254	6	term	term	NN
cord-018764-02l423mk	254	7	CM	CM	NNP
cord-018764-02l423mk	254	8	has	have	VBZ
cord-018764-02l423mk	254	9	been	be	VBN
cord-018764-02l423mk	254	10	restricted	restrict	VBN
cord-018764-02l423mk	254	11	to	to	IN
cord-018764-02l423mk	254	12	falciparum	falciparum	NN
cord-018764-02l423mk	254	13	malaria	malaria	NN
cord-018764-02l423mk	254	14	,	,	,
cord-018764-02l423mk	254	15	and	and	CC
cord-018764-02l423mk	254	16	patients	patient	NNS
cord-018764-02l423mk	254	17	with	with	IN
cord-018764-02l423mk	254	18	P.	P.	NNP
cord-018764-02l423mk	254	19	vivax	vivax	JJ
cord-018764-02l423mk	254	20	infection	infection	NN
cord-018764-02l423mk	254	21	exhibiting	exhibit	VBG
cord-018764-02l423mk	254	22	symptoms	symptom	NNS
cord-018764-02l423mk	254	23	of	of	IN
cord-018764-02l423mk	254	24	severe	severe	JJ
cord-018764-02l423mk	254	25	malaria	malaria	NN
cord-018764-02l423mk	254	26	,	,	,
cord-018764-02l423mk	254	27	including	include	VBG
cord-018764-02l423mk	254	28	coma	coma	NN
cord-018764-02l423mk	254	29	,	,	,
cord-018764-02l423mk	254	30	have	have	VBP
cord-018764-02l423mk	254	31	been	be	VBN
cord-018764-02l423mk	254	32	dismissed	dismiss	VBN
cord-018764-02l423mk	254	33	as	as	IN
cord-018764-02l423mk	254	34	undiagnosed	undiagnosed	JJ
cord-018764-02l423mk	254	35	falciparum	falciparum	NN
cord-018764-02l423mk	254	36	co	co	NNS
cord-018764-02l423mk	254	37	-	-	NNS
cord-018764-02l423mk	254	38	infections	infection	NNS
cord-018764-02l423mk	254	39	.	.	.
cord-018764-02l423mk	255	1	However	however	RB
cord-018764-02l423mk	255	2	,	,	,
cord-018764-02l423mk	255	3	the	the	DT
cord-018764-02l423mk	255	4	use	use	NN
cord-018764-02l423mk	255	5	of	of	IN
cord-018764-02l423mk	255	6	more	more	RBR
cord-018764-02l423mk	255	7	sensitive	sensitive	JJ
cord-018764-02l423mk	255	8	diagnostic	diagnostic	JJ
cord-018764-02l423mk	255	9	techniques	technique	NNS
cord-018764-02l423mk	255	10	makes	make	VBZ
cord-018764-02l423mk	255	11	such	such	JJ
cord-018764-02l423mk	255	12	dismissal	dismissal	NN
cord-018764-02l423mk	255	13	less	less	RBR
cord-018764-02l423mk	255	14	tenable	tenable	JJ
cord-018764-02l423mk	255	15	.	.	.
cord-018764-02l423mk	256	1	Two	two	CD
cord-018764-02l423mk	256	2	such	such	JJ
cord-018764-02l423mk	256	3	studies	study	NNS
cord-018764-02l423mk	256	4	report	report	VBP
cord-018764-02l423mk	256	5	adults	adult	NNS
cord-018764-02l423mk	256	6	exhibiting	exhibit	VBG
cord-018764-02l423mk	256	7	severe	severe	JJ
cord-018764-02l423mk	256	8	malaria	malaria	NN
cord-018764-02l423mk	256	9	with	with	IN
cord-018764-02l423mk	256	10	P.	p.	NN
cord-018764-02l423mk	256	11	vivax	vivax	NN
cord-018764-02l423mk	256	12	(	(	-LRB-
cord-018764-02l423mk	256	13	but	but	CC
cord-018764-02l423mk	256	14	not	not	RB
cord-018764-02l423mk	256	15	P.	P.	NNP
cord-018764-02l423mk	256	16	falciparum	falciparum	NN
cord-018764-02l423mk	256	17	)	)	-RRB-
cord-018764-02l423mk	257	1	infection	infection	NN
cord-018764-02l423mk	257	2	detectable	detectable	JJ
cord-018764-02l423mk	257	3	on	on	IN
cord-018764-02l423mk	257	4	PCR	PCR	NNP
cord-018764-02l423mk	257	5	and	and	CC
cord-018764-02l423mk	257	6	serological	serological	JJ
cord-018764-02l423mk	257	7	and	and	CC
cord-018764-02l423mk	257	8	testing	test	VBG
cord-018764-02l423mk	257	9	[	[	-LRB-
cord-018764-02l423mk	257	10	142	142	CD
cord-018764-02l423mk	257	11	,	,	,
cord-018764-02l423mk	257	12	143	143	CD
cord-018764-02l423mk	257	13	]	]	-RRB-
cord-018764-02l423mk	257	14	.	.	.
cord-018764-02l423mk	258	1	The	the	DT
cord-018764-02l423mk	258	2	patients	patient	NNS
cord-018764-02l423mk	258	3	exhibited	exhibit	VBD
cord-018764-02l423mk	258	4	multiple	multiple	JJ
cord-018764-02l423mk	258	5	organ	organ	NN
cord-018764-02l423mk	258	6	failure	failure	NN
cord-018764-02l423mk	258	7	including	include	VBG
cord-018764-02l423mk	258	8	cerebral	cerebral	JJ
cord-018764-02l423mk	258	9	symptoms	symptom	NNS
cord-018764-02l423mk	258	10	,	,	,
cord-018764-02l423mk	258	11	renal	renal	JJ
cord-018764-02l423mk	258	12	failure	failure	NN
cord-018764-02l423mk	258	13	,	,	,
cord-018764-02l423mk	258	14	circulatory	circulatory	JJ
cord-018764-02l423mk	258	15	collapse	collapse	NN
cord-018764-02l423mk	258	16	,	,	,
cord-018764-02l423mk	258	17	severe	severe	JJ
cord-018764-02l423mk	258	18	anaemia	anaemia	NN
cord-018764-02l423mk	258	19	,	,	,
cord-018764-02l423mk	258	20	haemoglobinuria	haemoglobinuria	NNP
cord-018764-02l423mk	258	21	,	,	,
cord-018764-02l423mk	258	22	abnormal	abnormal	JJ
cord-018764-02l423mk	258	23	bleeding	bleed	VBG
cord-018764-02l423mk	258	24	,	,	,
cord-018764-02l423mk	258	25	acute	acute	JJ
cord-018764-02l423mk	258	26	respiratory	respiratory	JJ
cord-018764-02l423mk	258	27	distress	distress	NN
cord-018764-02l423mk	258	28	syndrome	syndrome	NN
cord-018764-02l423mk	258	29	,	,	,
cord-018764-02l423mk	258	30	and	and	CC
cord-018764-02l423mk	258	31	jaundice	jaundice	NN
cord-018764-02l423mk	258	32	.	.	.
cord-018764-02l423mk	259	1	Vivax	vivax	JJ
cord-018764-02l423mk	259	2	malaria	malaria	NN
cord-018764-02l423mk	259	3	has	have	VBZ
cord-018764-02l423mk	259	4	been	be	VBN
cord-018764-02l423mk	259	5	associated	associate	VBN
cord-018764-02l423mk	259	6	with	with	IN
cord-018764-02l423mk	259	7	a	a	DT
cord-018764-02l423mk	259	8	strong	strong	JJ
cord-018764-02l423mk	259	9	systemic	systemic	JJ
cord-018764-02l423mk	259	10	inflammatory	inflammatory	JJ
cord-018764-02l423mk	259	11	response	response	NN
cord-018764-02l423mk	259	12	[	[	-LRB-
cord-018764-02l423mk	259	13	164	164	CD
cord-018764-02l423mk	259	14	]	]	-RRB-
cord-018764-02l423mk	259	15	,	,	,
cord-018764-02l423mk	259	16	but	but	CC
cord-018764-02l423mk	259	17	this	this	DT
cord-018764-02l423mk	259	18	was	be	VBD
cord-018764-02l423mk	259	19	not	not	RB
cord-018764-02l423mk	259	20	investigated	investigate	VBN
cord-018764-02l423mk	259	21	in	in	IN
cord-018764-02l423mk	259	22	the	the	DT
cord-018764-02l423mk	259	23	above	above	JJ
cord-018764-02l423mk	259	24	studies	study	NNS
cord-018764-02l423mk	259	25	.	.	.
cord-018764-02l423mk	260	1	Sepsis	sepsis	NN
cord-018764-02l423mk	260	2	-	-	HYPH
cord-018764-02l423mk	260	3	associated	associate	VBN
cord-018764-02l423mk	260	4	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	261	1	(	(	-LRB-
cord-018764-02l423mk	261	2	SAE	SAE	NNP
cord-018764-02l423mk	261	3	)	)	-RRB-
cord-018764-02l423mk	261	4	syndrome	syndrome	NN
cord-018764-02l423mk	261	5	has	have	VBZ
cord-018764-02l423mk	261	6	multiple	multiple	JJ
cord-018764-02l423mk	261	7	features	feature	NNS
cord-018764-02l423mk	261	8	that	that	WDT
cord-018764-02l423mk	261	9	resemble	resemble	VBP
cord-018764-02l423mk	261	10	CM	cm	NN
cord-018764-02l423mk	261	11	.	.	.
cord-018764-02l423mk	262	1	It	-PRON-	PRP
cord-018764-02l423mk	262	2	is	be	VBZ
cord-018764-02l423mk	262	3	characterised	characterise	VBN
cord-018764-02l423mk	262	4	by	by	IN
cord-018764-02l423mk	262	5	a	a	DT
cord-018764-02l423mk	262	6	diffuse	diffuse	JJ
cord-018764-02l423mk	262	7	disturbance	disturbance	NN
cord-018764-02l423mk	262	8	of	of	IN
cord-018764-02l423mk	262	9	cerebral	cerebral	JJ
cord-018764-02l423mk	262	10	function	function	NN
cord-018764-02l423mk	262	11	(	(	-LRB-
cord-018764-02l423mk	262	12	typically	typically	RB
cord-018764-02l423mk	262	13	impairment	impairment	NN
cord-018764-02l423mk	262	14	of	of	IN
cord-018764-02l423mk	262	15	consciousness	consciousness	NN
cord-018764-02l423mk	262	16	)	)	-RRB-
cord-018764-02l423mk	262	17	that	that	WDT
cord-018764-02l423mk	262	18	occurs	occur	VBZ
cord-018764-02l423mk	262	19	in	in	IN
cord-018764-02l423mk	262	20	the	the	DT
cord-018764-02l423mk	262	21	context	context	NN
cord-018764-02l423mk	262	22	of	of	IN
cord-018764-02l423mk	262	23	systemic	systemic	JJ
cord-018764-02l423mk	262	24	response	response	NN
cord-018764-02l423mk	262	25	to	to	IN
cord-018764-02l423mk	262	26	infection	infection	NN
cord-018764-02l423mk	262	27	without	without	IN
cord-018764-02l423mk	262	28	direct	direct	JJ
cord-018764-02l423mk	262	29	neuroinvasion	neuroinvasion	NN
cord-018764-02l423mk	262	30	(	(	-LRB-
cord-018764-02l423mk	262	31	i.e.	i.e.	FW
cord-018764-02l423mk	262	32	meningitis	meningitis	NN
cord-018764-02l423mk	262	33	,	,	,
cord-018764-02l423mk	262	34	macroscopic	macroscopic	JJ
cord-018764-02l423mk	262	35	cerebritis	cerebritis	NN
cord-018764-02l423mk	262	36	and	and	CC
cord-018764-02l423mk	262	37	brain	brain	NN
cord-018764-02l423mk	262	38	abscesses	abscess	NNS
cord-018764-02l423mk	262	39	are	be	VBP
cord-018764-02l423mk	262	40	excluded	exclude	VBN
cord-018764-02l423mk	262	41	)	)	-RRB-
cord-018764-02l423mk	262	42	.	.	.
cord-018764-02l423mk	263	1	SAE	SAE	NNP
cord-018764-02l423mk	263	2	is	be	VBZ
cord-018764-02l423mk	263	3	associated	associate	VBN
cord-018764-02l423mk	263	4	with	with	IN
cord-018764-02l423mk	263	5	generalised	generalised	JJ
cord-018764-02l423mk	263	6	slow	slow	JJ
cord-018764-02l423mk	263	7	waves	wave	NNS
cord-018764-02l423mk	263	8	on	on	IN
cord-018764-02l423mk	263	9	the	the	DT
cord-018764-02l423mk	263	10	electroencephalogram	electroencephalogram	NN
cord-018764-02l423mk	263	11	(	(	-LRB-
cord-018764-02l423mk	263	12	EEG	EEG	NNP
cord-018764-02l423mk	263	13	)	)	-RRB-
cord-018764-02l423mk	263	14	,	,	,
cord-018764-02l423mk	263	15	with	with	IN
cord-018764-02l423mk	263	16	the	the	DT
cord-018764-02l423mk	263	17	depth	depth	NN
cord-018764-02l423mk	263	18	of	of	IN
cord-018764-02l423mk	263	19	coma	coma	NN
cord-018764-02l423mk	263	20	linked	link	VBN
cord-018764-02l423mk	263	21	with	with	IN
cord-018764-02l423mk	263	22	mortality	mortality	NN
cord-018764-02l423mk	263	23	.	.	.
cord-018764-02l423mk	264	1	Mild	mild	JJ
cord-018764-02l423mk	264	2	SAE	SAE	NNP
cord-018764-02l423mk	264	3	cases	case	NNS
cord-018764-02l423mk	264	4	often	often	RB
cord-018764-02l423mk	264	5	recover	recover	VBP
cord-018764-02l423mk	264	6	completely	completely	RB
cord-018764-02l423mk	264	7	,	,	,
cord-018764-02l423mk	264	8	while	while	IN
cord-018764-02l423mk	264	9	survivors	survivor	NNS
cord-018764-02l423mk	264	10	of	of	IN
cord-018764-02l423mk	264	11	severe	severe	JJ
cord-018764-02l423mk	264	12	SAE	SAE	NNP
cord-018764-02l423mk	264	13	may	may	MD
cord-018764-02l423mk	264	14	have	have	VB
cord-018764-02l423mk	264	15	persistent	persistent	JJ
cord-018764-02l423mk	264	16	neurological	neurological	JJ
cord-018764-02l423mk	264	17	deficit	deficit	NN
cord-018764-02l423mk	264	18	[	[	-LRB-
cord-018764-02l423mk	264	19	165	165	CD
cord-018764-02l423mk	264	20	]	]	-RRB-
cord-018764-02l423mk	264	21	)	)	-RRB-
cord-018764-02l423mk	264	22	.	.	.
cord-018764-02l423mk	265	1	In	in	IN
cord-018764-02l423mk	265	2	line	line	NN
cord-018764-02l423mk	265	3	with	with	IN
cord-018764-02l423mk	265	4	adult	adult	NN
cord-018764-02l423mk	265	5	CM	cm	NN
cord-018764-02l423mk	265	6	,	,	,
cord-018764-02l423mk	265	7	the	the	DT
cord-018764-02l423mk	265	8	severity	severity	NN
cord-018764-02l423mk	265	9	of	of	IN
cord-018764-02l423mk	265	10	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	265	11	parallels	parallel	VBZ
cord-018764-02l423mk	265	12	the	the	DT
cord-018764-02l423mk	265	13	severity	severity	NN
cord-018764-02l423mk	265	14	of	of	IN
cord-018764-02l423mk	265	15	systemic	systemic	JJ
cord-018764-02l423mk	265	16	organ	organ	NN
cord-018764-02l423mk	265	17	failure	failure	NN
cord-018764-02l423mk	265	18	[	[	-LRB-
cord-018764-02l423mk	265	19	141	141	CD
cord-018764-02l423mk	265	20	]	]	-RRB-
cord-018764-02l423mk	265	21	.	.	.
cord-018764-02l423mk	266	1	Inflammatory	inflammatory	JJ
cord-018764-02l423mk	266	2	cytokines	cytokine	NNS
cord-018764-02l423mk	266	3	have	have	VBP
cord-018764-02l423mk	266	4	been	be	VBN
cord-018764-02l423mk	266	5	demonstrated	demonstrate	VBN
cord-018764-02l423mk	266	6	to	to	TO
cord-018764-02l423mk	266	7	be	be	VB
cord-018764-02l423mk	266	8	higher	high	JJR
cord-018764-02l423mk	266	9	in	in	IN
cord-018764-02l423mk	266	10	the	the	DT
cord-018764-02l423mk	266	11	serum	serum	NN
cord-018764-02l423mk	266	12	than	than	IN
cord-018764-02l423mk	266	13	in	in	IN
cord-018764-02l423mk	266	14	the	the	DT
cord-018764-02l423mk	266	15	CSF	CSF	NNP
cord-018764-02l423mk	266	16	,	,	,
cord-018764-02l423mk	266	17	suggesting	suggest	VBG
cord-018764-02l423mk	266	18	that	that	IN
cord-018764-02l423mk	266	19	sepsis	sepsis	NN
cord-018764-02l423mk	266	20	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	266	21	is	be	VBZ
cord-018764-02l423mk	266	22	a	a	DT
cord-018764-02l423mk	266	23	consequence	consequence	NN
cord-018764-02l423mk	266	24	of	of	IN
cord-018764-02l423mk	266	25	the	the	DT
cord-018764-02l423mk	266	26	systemic	systemic	JJ
cord-018764-02l423mk	266	27	inflammatory	inflammatory	JJ
cord-018764-02l423mk	266	28	response	response	NN
cord-018764-02l423mk	266	29	to	to	IN
cord-018764-02l423mk	266	30	infection	infection	NN
cord-018764-02l423mk	266	31	[	[	-LRB-
cord-018764-02l423mk	266	32	141	141	CD
cord-018764-02l423mk	266	33	]	]	-RRB-
cord-018764-02l423mk	266	34	.	.	.
cord-018764-02l423mk	267	1	An	an	DT
cord-018764-02l423mk	267	2	animal	animal	NN
cord-018764-02l423mk	267	3	model	model	NN
cord-018764-02l423mk	267	4	in	in	IN
cord-018764-02l423mk	267	5	which	which	WDT
cord-018764-02l423mk	267	6	prior	prior	JJ
cord-018764-02l423mk	267	7	administration	administration	NN
cord-018764-02l423mk	267	8	of	of	IN
cord-018764-02l423mk	267	9	a	a	DT
cord-018764-02l423mk	267	10	neutralising	neutralise	VBG
cord-018764-02l423mk	267	11	antibody	antibody	NN
cord-018764-02l423mk	267	12	to	to	IN
cord-018764-02l423mk	267	13	TNF	TNF	NNP
cord-018764-02l423mk	267	14	prevented	prevent	VBD
cord-018764-02l423mk	267	15	the	the	DT
cord-018764-02l423mk	267	16	sepsis	sepsis	NN
cord-018764-02l423mk	267	17	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	267	18	of	of	IN
cord-018764-02l423mk	267	19	pancreatitis	pancreatitis	NN
cord-018764-02l423mk	267	20	[	[	-LRB-
cord-018764-02l423mk	267	21	166	166	CD
cord-018764-02l423mk	267	22	]	]	-RRB-
cord-018764-02l423mk	267	23	is	be	VBZ
cord-018764-02l423mk	267	24	consistent	consistent	JJ
cord-018764-02l423mk	267	25	with	with	IN
cord-018764-02l423mk	267	26	this	this	DT
cord-018764-02l423mk	267	27	.	.	.
cord-018764-02l423mk	268	1	Further	further	RB
cord-018764-02l423mk	268	2	postulated	postulate	VBN
cord-018764-02l423mk	268	3	reversible	reversible	JJ
cord-018764-02l423mk	268	4	mechanisms	mechanism	NNS
cord-018764-02l423mk	268	5	of	of	IN
cord-018764-02l423mk	268	6	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	268	7	include	include	VBP
cord-018764-02l423mk	268	8	changes	change	NNS
cord-018764-02l423mk	268	9	in	in	IN
cord-018764-02l423mk	268	10	regional	regional	JJ
cord-018764-02l423mk	268	11	cerebral	cerebral	JJ
cord-018764-02l423mk	268	12	blood	blood	NN
cord-018764-02l423mk	268	13	flow	flow	NN
cord-018764-02l423mk	268	14	,	,	,
cord-018764-02l423mk	268	15	neurotransmitter	neurotransmitter	NN
cord-018764-02l423mk	268	16	imbalance	imbalance	NN
cord-018764-02l423mk	268	17	,	,	,
cord-018764-02l423mk	268	18	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	268	19	dysfunction	dysfunction	NN
cord-018764-02l423mk	268	20	,	,	,
cord-018764-02l423mk	268	21	BBB	BBB	NNP
cord-018764-02l423mk	268	22	impairment	impairment	NN
cord-018764-02l423mk	268	23	and	and	CC
cord-018764-02l423mk	268	24	oxidative	oxidative	JJ
cord-018764-02l423mk	268	25	stress	stress	NN
cord-018764-02l423mk	268	26	[	[	-LRB-
cord-018764-02l423mk	268	27	167	167	CD
cord-018764-02l423mk	268	28	]	]	-RRB-
cord-018764-02l423mk	268	29	.	.	.
cord-018764-02l423mk	269	1	Severe	severe	JJ
cord-018764-02l423mk	269	2	influenza	influenza	NN
cord-018764-02l423mk	269	3	infection	infection	NN
cord-018764-02l423mk	269	4	can	can	MD
cord-018764-02l423mk	269	5	present	present	VB
cord-018764-02l423mk	269	6	with	with	IN
cord-018764-02l423mk	269	7	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	269	8	,	,	,
cord-018764-02l423mk	269	9	yet	yet	CC
cord-018764-02l423mk	269	10	as	as	IN
cord-018764-02l423mk	269	11	in	in	IN
cord-018764-02l423mk	269	12	malaria	malaria	NN
cord-018764-02l423mk	269	13	,	,	,
cord-018764-02l423mk	269	14	the	the	DT
cord-018764-02l423mk	269	15	pathogen	pathogen	NN
cord-018764-02l423mk	269	16	is	be	VBZ
cord-018764-02l423mk	269	17	not	not	RB
cord-018764-02l423mk	269	18	neuroinvasive	neuroinvasive	JJ
cord-018764-02l423mk	269	19	[	[	-LRB-
cord-018764-02l423mk	269	20	168	168	CD
cord-018764-02l423mk	269	21	]	]	-RRB-
cord-018764-02l423mk	269	22	.	.	.
cord-018764-02l423mk	270	1	Seizures	seizure	NNS
cord-018764-02l423mk	270	2	and	and	CC
cord-018764-02l423mk	270	3	coma	coma	NN
cord-018764-02l423mk	270	4	occur	occur	VBP
cord-018764-02l423mk	270	5	after	after	IN
cord-018764-02l423mk	270	6	high	high	JJ
cord-018764-02l423mk	270	7	fever	fever	NN
cord-018764-02l423mk	270	8	[	[	-LRB-
cord-018764-02l423mk	270	9	169	169	CD
cord-018764-02l423mk	270	10	]	]	-RRB-
cord-018764-02l423mk	270	11	,	,	,
cord-018764-02l423mk	270	12	commonly	commonly	RB
cord-018764-02l423mk	270	13	accompanied	accompany	VBN
cord-018764-02l423mk	270	14	by	by	IN
cord-018764-02l423mk	270	15	thrombocytopaenia	thrombocytopaenia	NNP
cord-018764-02l423mk	270	16	[	[	-LRB-
cord-018764-02l423mk	270	17	169	169	CD
cord-018764-02l423mk	270	18	]	]	-RRB-
cord-018764-02l423mk	270	19	,	,	,
cord-018764-02l423mk	270	20	with	with	IN
cord-018764-02l423mk	270	21	metabolic	metabolic	JJ
cord-018764-02l423mk	270	22	acidosis	acidosis	NN
cord-018764-02l423mk	270	23	and	and	CC
cord-018764-02l423mk	270	24	hyperlactataemia	hyperlactataemia	NN
cord-018764-02l423mk	270	25	in	in	IN
cord-018764-02l423mk	270	26	severe	severe	JJ
cord-018764-02l423mk	270	27	cases	case	NNS
cord-018764-02l423mk	271	1	(	(	-LRB-
cord-018764-02l423mk	271	2	T.	T.	NNP
cord-018764-02l423mk	271	3	Ichiyama	Ichiyama	NNP
cord-018764-02l423mk	271	4	,	,	,
cord-018764-02l423mk	271	5	personal	personal	JJ
cord-018764-02l423mk	271	6	communication	communication	NN
cord-018764-02l423mk	271	7	)	)	-RRB-
cord-018764-02l423mk	271	8	.	.	.
cord-018764-02l423mk	272	1	Similar	similar	JJ
cord-018764-02l423mk	272	2	to	to	IN
cord-018764-02l423mk	272	3	adult	adult	NN
cord-018764-02l423mk	272	4	malaria	malaria	NN
cord-018764-02l423mk	272	5	,	,	,
cord-018764-02l423mk	272	6	neurological	neurological	JJ
cord-018764-02l423mk	272	7	sequelae	sequela	NNS
cord-018764-02l423mk	272	8	occur	occur	VBP
cord-018764-02l423mk	272	9	concurrently	concurrently	RB
cord-018764-02l423mk	272	10	with	with	IN
cord-018764-02l423mk	272	11	multiple	multiple	JJ
cord-018764-02l423mk	272	12	organ	organ	NN
cord-018764-02l423mk	272	13	failure	failure	NN
cord-018764-02l423mk	272	14	[	[	-LRB-
cord-018764-02l423mk	272	15	170	170	CD
cord-018764-02l423mk	272	16	]	]	-RRB-
cord-018764-02l423mk	272	17	.	.	.
cord-018764-02l423mk	273	1	TNF	TNF	NNP
cord-018764-02l423mk	273	2	,	,	,
cord-018764-02l423mk	273	3	IL-6	IL-6	NNP
cord-018764-02l423mk	273	4	,	,	,
cord-018764-02l423mk	273	5	sTNFRI	stnfri	JJ
cord-018764-02l423mk	273	6	,	,	,
cord-018764-02l423mk	273	7	and	and	CC
cord-018764-02l423mk	273	8	soluble	soluble	JJ
cord-018764-02l423mk	273	9	E	e	NN
cord-018764-02l423mk	273	10	-	-	NN
cord-018764-02l423mk	273	11	selectin	selectin	NNP
cord-018764-02l423mk	273	12	are	be	VBP
cord-018764-02l423mk	273	13	increased	increase	VBN
cord-018764-02l423mk	273	14	in	in	IN
cord-018764-02l423mk	273	15	serum	serum	NN
cord-018764-02l423mk	273	16	and	and	CC
cord-018764-02l423mk	273	17	CSF	CSF	NNP
cord-018764-02l423mk	273	18	[	[	-LRB-
cord-018764-02l423mk	273	19	171	171	CD
cord-018764-02l423mk	273	20	,	,	,
cord-018764-02l423mk	273	21	172	172	CD
cord-018764-02l423mk	273	22	]	]	-RRB-
cord-018764-02l423mk	273	23	,	,	,
cord-018764-02l423mk	273	24	and	and	CC
cord-018764-02l423mk	273	25	serum	serum	NN
cord-018764-02l423mk	273	26	nitrite	nitrite	NN
cord-018764-02l423mk	273	27	/	/	SYM
cord-018764-02l423mk	273	28	nitrate	nitrate	NN
cord-018764-02l423mk	273	29	levels	level	NNS
cord-018764-02l423mk	273	30	are	be	VBP
cord-018764-02l423mk	273	31	increased	increase	VBN
cord-018764-02l423mk	273	32	[	[	-LRB-
cord-018764-02l423mk	273	33	173	173	CD
cord-018764-02l423mk	273	34	]	]	-RRB-
cord-018764-02l423mk	273	35	.	.	.
cord-018764-02l423mk	274	1	Detailed	detailed	JJ
cord-018764-02l423mk	274	2	examination	examination	NN
cord-018764-02l423mk	274	3	of	of	IN
cord-018764-02l423mk	274	4	brain	brain	NN
cord-018764-02l423mk	274	5	has	have	VBZ
cord-018764-02l423mk	274	6	revealed	reveal	VBN
cord-018764-02l423mk	274	7	apoptosis	apoptosis	NN
cord-018764-02l423mk	274	8	of	of	IN
cord-018764-02l423mk	274	9	neurons	neuron	NNS
cord-018764-02l423mk	274	10	and	and	CC
cord-018764-02l423mk	274	11	glial	glial	JJ
cord-018764-02l423mk	274	12	cell	cell	NN
cord-018764-02l423mk	274	13	,	,	,
cord-018764-02l423mk	274	14	histological	histological	JJ
cord-018764-02l423mk	274	15	evidence	evidence	NN
cord-018764-02l423mk	274	16	of	of	IN
cord-018764-02l423mk	274	17	active	active	JJ
cord-018764-02l423mk	274	18	caspase-3	caspase-3	NNP
cord-018764-02l423mk	274	19	and	and	CC
cord-018764-02l423mk	274	20	caspase	caspase	NN
cord-018764-02l423mk	274	21	-	-	HYPH
cord-018764-02l423mk	274	22	cleaved	cleave	VBN
cord-018764-02l423mk	274	23	PARP	PARP	NNP
cord-018764-02l423mk	274	24	,	,	,
cord-018764-02l423mk	274	25	cerebral	cerebral	JJ
cord-018764-02l423mk	274	26	oedema	oedema	NN
cord-018764-02l423mk	274	27	,	,	,
cord-018764-02l423mk	274	28	and	and	CC
cord-018764-02l423mk	274	29	BBB	BBB	NNP
cord-018764-02l423mk	274	30	impairment	impairment	NN
cord-018764-02l423mk	274	31	[	[	-LRB-
cord-018764-02l423mk	274	32	174	174	CD
cord-018764-02l423mk	274	33	]	]	-RRB-
cord-018764-02l423mk	274	34	.	.	.
cord-018764-02l423mk	275	1	These	these	DT
cord-018764-02l423mk	275	2	parallel	parallel	JJ
cord-018764-02l423mk	275	3	changes	change	NNS
cord-018764-02l423mk	275	4	are	be	VBP
cord-018764-02l423mk	275	5	set	set	VBN
cord-018764-02l423mk	275	6	out	out	RP
cord-018764-02l423mk	275	7	in	in	IN
cord-018764-02l423mk	275	8	Table	Table	NNP
cord-018764-02l423mk	275	9	3	3	CD
cord-018764-02l423mk	275	10	.	.	.
cord-018764-02l423mk	276	1	It	-PRON-	PRP
cord-018764-02l423mk	276	2	is	be	VBZ
cord-018764-02l423mk	276	3	clear	clear	JJ
cord-018764-02l423mk	276	4	,	,	,
cord-018764-02l423mk	276	5	therefore	therefore	RB
cord-018764-02l423mk	276	6	,	,	,
cord-018764-02l423mk	276	7	that	that	IN
cord-018764-02l423mk	276	8	the	the	DT
cord-018764-02l423mk	276	9	presence	presence	NN
cord-018764-02l423mk	276	10	of	of	IN
cord-018764-02l423mk	276	11	sequestering	sequester	VBG
cord-018764-02l423mk	276	12	parasitised	parasitise	VBN
cord-018764-02l423mk	276	13	red	red	JJ
cord-018764-02l423mk	276	14	cells	cell	NNS
cord-018764-02l423mk	276	15	is	be	VBZ
cord-018764-02l423mk	276	16	not	not	RB
cord-018764-02l423mk	276	17	necessary	necessary	JJ
cord-018764-02l423mk	276	18	to	to	TO
cord-018764-02l423mk	276	19	generate	generate	VB
cord-018764-02l423mk	276	20	these	these	DT
cord-018764-02l423mk	276	21	changes	change	NNS
cord-018764-02l423mk	276	22	,	,	,
cord-018764-02l423mk	276	23	which	which	WDT
cord-018764-02l423mk	276	24	are	be	VBP
cord-018764-02l423mk	276	25	also	also	RB
cord-018764-02l423mk	276	26	demonstrable	demonstrable	JJ
cord-018764-02l423mk	276	27	in	in	IN
cord-018764-02l423mk	276	28	the	the	DT
cord-018764-02l423mk	276	29	falciparum	falciparum	NN
cord-018764-02l423mk	276	30	malaria	malaria	NN
cord-018764-02l423mk	276	31	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	276	32	.	.	.
cord-018764-02l423mk	277	1	Notably	notably	RB
cord-018764-02l423mk	277	2	,	,	,
cord-018764-02l423mk	277	3	high	high	JJ
cord-018764-02l423mk	277	4	levels	level	NNS
cord-018764-02l423mk	277	5	of	of	IN
cord-018764-02l423mk	277	6	inflammatory	inflammatory	JJ
cord-018764-02l423mk	277	7	cytokine	cytokine	NN
cord-018764-02l423mk	277	8	are	be	VBP
cord-018764-02l423mk	277	9	present	present	JJ
cord-018764-02l423mk	277	10	in	in	IN
cord-018764-02l423mk	277	11	each	each	DT
cord-018764-02l423mk	277	12	disease	disease	NN
cord-018764-02l423mk	277	13	.	.	.
cord-018764-02l423mk	277	14	 	 	_SP
cord-018764-02l423mk	278	1	Seizures	seizure	NNS
cord-018764-02l423mk	278	2	are	be	VBP
cord-018764-02l423mk	278	3	a	a	DT
cord-018764-02l423mk	278	4	very	very	RB
cord-018764-02l423mk	278	5	common	common	JJ
cord-018764-02l423mk	278	6	component	component	NN
cord-018764-02l423mk	278	7	of	of	IN
cord-018764-02l423mk	278	8	acute	acute	JJ
cord-018764-02l423mk	278	9	malaria	malaria	NN
cord-018764-02l423mk	278	10	illness	illness	NN
cord-018764-02l423mk	278	11	in	in	IN
cord-018764-02l423mk	278	12	children	child	NNS
cord-018764-02l423mk	278	13	.	.	.
cord-018764-02l423mk	279	1	A	a	DT
cord-018764-02l423mk	279	2	recent	recent	JJ
cord-018764-02l423mk	279	3	review	review	NN
cord-018764-02l423mk	279	4	documented	document	VBD
cord-018764-02l423mk	279	5	that	that	IN
cord-018764-02l423mk	279	6	80	80	CD
cord-018764-02l423mk	279	7	%	%	NN
cord-018764-02l423mk	279	8	of	of	IN
cord-018764-02l423mk	279	9	African	african	JJ
cord-018764-02l423mk	279	10	children	child	NNS
cord-018764-02l423mk	279	11	had	have	VBD
cord-018764-02l423mk	279	12	a	a	DT
cord-018764-02l423mk	279	13	history	history	NN
cord-018764-02l423mk	279	14	of	of	IN
cord-018764-02l423mk	279	15	seizures	seizure	NNS
cord-018764-02l423mk	279	16	,	,	,
cord-018764-02l423mk	279	17	with	with	IN
cord-018764-02l423mk	279	18	60	60	CD
cord-018764-02l423mk	279	19	%	%	NN
cord-018764-02l423mk	279	20	exhibiting	exhibit	VBG
cord-018764-02l423mk	279	21	seizures	seizure	NNS
cord-018764-02l423mk	279	22	during	during	IN
cord-018764-02l423mk	279	23	hospital	hospital	NN
cord-018764-02l423mk	279	24	admission	admission	NN
cord-018764-02l423mk	279	25	[	[	-LRB-
cord-018764-02l423mk	279	26	175	175	CD
cord-018764-02l423mk	279	27	]	]	-RRB-
cord-018764-02l423mk	279	28	.	.	.
cord-018764-02l423mk	280	1	The	the	DT
cord-018764-02l423mk	280	2	molecular	molecular	JJ
cord-018764-02l423mk	280	3	basis	basis	NN
cord-018764-02l423mk	280	4	of	of	IN
cord-018764-02l423mk	280	5	the	the	DT
cord-018764-02l423mk	280	6	seizures	seizure	NNS
cord-018764-02l423mk	280	7	is	be	VBZ
cord-018764-02l423mk	280	8	unclear	unclear	JJ
cord-018764-02l423mk	280	9	.	.	.
cord-018764-02l423mk	281	1	Multiple	multiple	JJ
cord-018764-02l423mk	281	2	mechanisms	mechanism	NNS
cord-018764-02l423mk	281	3	have	have	VBP
cord-018764-02l423mk	281	4	been	be	VBN
cord-018764-02l423mk	281	5	postulated	postulate	VBN
cord-018764-02l423mk	281	6	,	,	,
cord-018764-02l423mk	281	7	including	include	VBG
cord-018764-02l423mk	281	8	fever	fever	NN
cord-018764-02l423mk	281	9	,	,	,
cord-018764-02l423mk	281	10	hypoxia	hypoxia	NN
cord-018764-02l423mk	281	11	and/or	and/or	CC
cord-018764-02l423mk	281	12	cytokine	cytokine	JJ
cord-018764-02l423mk	281	13	stimulation	stimulation	NN
cord-018764-02l423mk	281	14	leading	lead	VBG
cord-018764-02l423mk	281	15	to	to	IN
cord-018764-02l423mk	281	16	an	an	DT
cord-018764-02l423mk	281	17	imbalance	imbalance	NN
cord-018764-02l423mk	281	18	of	of	IN
cord-018764-02l423mk	281	19	neurotransmitters	neurotransmitter	NNS
cord-018764-02l423mk	281	20	and	and	CC
cord-018764-02l423mk	281	21	excitotoxins	excitotoxin	NNS
cord-018764-02l423mk	281	22	or	or	CC
cord-018764-02l423mk	281	23	neuronal	neuronal	JJ
cord-018764-02l423mk	281	24	damage	damage	NN
cord-018764-02l423mk	281	25	[	[	-LRB-
cord-018764-02l423mk	281	26	11	11	CD
cord-018764-02l423mk	281	27	,	,	,
cord-018764-02l423mk	281	28	148	148	CD
cord-018764-02l423mk	281	29	]	]	-RRB-
cord-018764-02l423mk	281	30	.	.	.
cord-018764-02l423mk	282	1	Recently	recently	RB
cord-018764-02l423mk	282	2	,	,	,
cord-018764-02l423mk	282	3	Lang	Lang	NNP
cord-018764-02l423mk	282	4	and	and	CC
cord-018764-02l423mk	282	5	co	co	NNS
cord-018764-02l423mk	282	6	-	-	NNS
cord-018764-02l423mk	282	7	workers	worker	NNS
cord-018764-02l423mk	282	8	[	[	-LRB-
cord-018764-02l423mk	282	9	176	176	CD
cord-018764-02l423mk	282	10	]	]	-RRB-
cord-018764-02l423mk	282	11	demonstrated	demonstrate	VBD
cord-018764-02l423mk	282	12	that	that	IN
cord-018764-02l423mk	282	13	falciparum	falciparum	NN
cord-018764-02l423mk	282	14	parasitaemia	parasitaemia	NNP
cord-018764-02l423mk	282	15	is	be	VBZ
cord-018764-02l423mk	282	16	associated	associate	VBN
cord-018764-02l423mk	282	17	with	with	IN
cord-018764-02l423mk	282	18	the	the	DT
cord-018764-02l423mk	282	19	generation	generation	NN
cord-018764-02l423mk	282	20	of	of	IN
cord-018764-02l423mk	282	21	specific	specific	JJ
cord-018764-02l423mk	282	22	antibodies	antibody	NNS
cord-018764-02l423mk	282	23	for	for	IN
cord-018764-02l423mk	282	24	voltage	voltage	NN
cord-018764-02l423mk	282	25	-	-	HYPH
cord-018764-02l423mk	282	26	gated	gate	VBN
cord-018764-02l423mk	282	27	calcium	calcium	NN
cord-018764-02l423mk	282	28	channels	channel	NNS
cord-018764-02l423mk	282	29	directed	direct	VBN
cord-018764-02l423mk	282	30	against	against	IN
cord-018764-02l423mk	282	31	neurones	neurone	NNS
cord-018764-02l423mk	282	32	.	.	.
cord-018764-02l423mk	283	1	Higher	high	JJR
cord-018764-02l423mk	283	2	antibody	antibody	NN
cord-018764-02l423mk	283	3	concentrations	concentration	NNS
cord-018764-02l423mk	283	4	were	be	VBD
cord-018764-02l423mk	283	5	detectable	detectable	JJ
cord-018764-02l423mk	283	6	in	in	IN
cord-018764-02l423mk	283	7	sera	sera	NNP
cord-018764-02l423mk	283	8	from	from	IN
cord-018764-02l423mk	283	9	patients	patient	NNS
cord-018764-02l423mk	283	10	exhibiting	exhibit	VBG
cord-018764-02l423mk	283	11	CM	cm	NN
cord-018764-02l423mk	283	12	or	or	CC
cord-018764-02l423mk	283	13	malaria	malaria	NN
cord-018764-02l423mk	283	14	with	with	IN
cord-018764-02l423mk	283	15	seizures	seizure	NNS
cord-018764-02l423mk	283	16	than	than	IN
cord-018764-02l423mk	283	17	uncomplicated	uncomplicated	JJ
cord-018764-02l423mk	283	18	malaria	malaria	NN
cord-018764-02l423mk	283	19	,	,	,
cord-018764-02l423mk	283	20	suggesting	suggest	VBG
cord-018764-02l423mk	283	21	that	that	IN
cord-018764-02l423mk	283	22	these	these	DT
cord-018764-02l423mk	283	23	antibodies	antibody	NNS
cord-018764-02l423mk	283	24	may	may	MD
cord-018764-02l423mk	283	25	influence	influence	VB
cord-018764-02l423mk	283	26	seizure	seizure	NN
cord-018764-02l423mk	283	27	propensity	propensity	NN
cord-018764-02l423mk	283	28	.	.	.
cord-018764-02l423mk	284	1	Only	only	RB
cord-018764-02l423mk	284	2	the	the	DT
cord-018764-02l423mk	284	3	erythrocytic	erythrocytic	JJ
cord-018764-02l423mk	284	4	form	form	NN
cord-018764-02l423mk	284	5	of	of	IN
cord-018764-02l423mk	284	6	malaria	malaria	NN
cord-018764-02l423mk	284	7	is	be	VBZ
cord-018764-02l423mk	284	8	associated	associate	VBN
cord-018764-02l423mk	284	9	with	with	IN
cord-018764-02l423mk	284	10	disease	disease	NN
cord-018764-02l423mk	284	11	,	,	,
cord-018764-02l423mk	284	12	so	so	RB
cord-018764-02l423mk	284	13	valuable	valuable	JJ
cord-018764-02l423mk	284	14	information	information	NN
cord-018764-02l423mk	284	15	about	about	IN
cord-018764-02l423mk	284	16	which	which	WDT
cord-018764-02l423mk	284	17	African	african	JJ
cord-018764-02l423mk	284	18	children	child	NNS
cord-018764-02l423mk	284	19	are	be	VBP
cord-018764-02l423mk	284	20	likely	likely	JJ
cord-018764-02l423mk	284	21	to	to	TO
cord-018764-02l423mk	284	22	have	have	VB
cord-018764-02l423mk	284	23	more	more	JJR
cord-018764-02l423mk	284	24	,	,	,
cord-018764-02l423mk	284	25	or	or	CC
cord-018764-02l423mk	284	26	less	less	JJR
cord-018764-02l423mk	284	27	,	,	,
cord-018764-02l423mk	284	28	severe	severe	JJ
cord-018764-02l423mk	284	29	malaria	malaria	NN
cord-018764-02l423mk	284	30	has	have	VBZ
cord-018764-02l423mk	284	31	inevitably	inevitably	RB
cord-018764-02l423mk	284	32	been	be	VBN
cord-018764-02l423mk	284	33	obtained	obtain	VBN
cord-018764-02l423mk	284	34	from	from	IN
cord-018764-02l423mk	284	35	examining	examine	VBG
cord-018764-02l423mk	284	36	the	the	DT
cord-018764-02l423mk	284	37	inborn	inborn	JJ
cord-018764-02l423mk	284	38	RBC	RBC	NNP
cord-018764-02l423mk	284	39	abnormalities	abnormality	NNS
cord-018764-02l423mk	284	40	that	that	IN
cord-018764-02l423mk	284	41	endemic	endemic	JJ
cord-018764-02l423mk	284	42	malaria	malaria	NN
cord-018764-02l423mk	284	43	has	have	VBZ
cord-018764-02l423mk	284	44	selected	select	VBN
cord-018764-02l423mk	284	45	across	across	IN
cord-018764-02l423mk	284	46	the	the	DT
cord-018764-02l423mk	284	47	tropics	tropic	NNS
cord-018764-02l423mk	284	48	.	.	.
cord-018764-02l423mk	285	1	The	the	DT
cord-018764-02l423mk	285	2	coinciding	coincide	VBG
cord-018764-02l423mk	285	3	geographic	geographic	JJ
cord-018764-02l423mk	285	4	distributions	distribution	NNS
cord-018764-02l423mk	285	5	of	of	IN
cord-018764-02l423mk	285	6	malaria	malaria	NN
cord-018764-02l423mk	285	7	transmission	transmission	NN
cord-018764-02l423mk	285	8	and	and	CC
cord-018764-02l423mk	285	9	the	the	DT
cord-018764-02l423mk	285	10	thalassaemias	thalassaemias	NNP
cord-018764-02l423mk	285	11	prompted	prompt	VBD
cord-018764-02l423mk	285	12	Haldane	Haldane	NNP
cord-018764-02l423mk	285	13	to	to	TO
cord-018764-02l423mk	285	14	put	put	VB
cord-018764-02l423mk	285	15	forward	forward	RP
cord-018764-02l423mk	285	16	the	the	DT
cord-018764-02l423mk	285	17	'	'	``
cord-018764-02l423mk	285	18	malaria	malaria	NN
cord-018764-02l423mk	285	19	hypothesis	hypothesis	NN
cord-018764-02l423mk	285	20	'	'	''
cord-018764-02l423mk	285	21	,	,	,
cord-018764-02l423mk	285	22	which	which	WDT
cord-018764-02l423mk	285	23	proposed	propose	VBD
cord-018764-02l423mk	285	24	that	that	IN
cord-018764-02l423mk	285	25	common	common	JJ
cord-018764-02l423mk	285	26	erythrocyte	erythrocyte	NN
cord-018764-02l423mk	285	27	abnormalities	abnormality	NNS
cord-018764-02l423mk	285	28	are	be	VBP
cord-018764-02l423mk	285	29	selected	select	VBN
cord-018764-02l423mk	285	30	because	because	IN
cord-018764-02l423mk	285	31	of	of	IN
cord-018764-02l423mk	285	32	the	the	DT
cord-018764-02l423mk	285	33	fitness	fitness	NN
cord-018764-02l423mk	285	34	advantage	advantage	NN
cord-018764-02l423mk	285	35	they	-PRON-	PRP
cord-018764-02l423mk	285	36	confer	confer	VBP
cord-018764-02l423mk	285	37	against	against	IN
cord-018764-02l423mk	285	38	malaria	malaria	NN
cord-018764-02l423mk	285	39	[	[	-LRB-
cord-018764-02l423mk	285	40	177	177	CD
cord-018764-02l423mk	285	41	]	]	-RRB-
cord-018764-02l423mk	285	42	.	.	.
cord-018764-02l423mk	286	1	Sickle	sickle	NN
cord-018764-02l423mk	286	2	cell	cell	NN
cord-018764-02l423mk	286	3	haemoglobin	haemoglobin	NN
cord-018764-02l423mk	286	4	(	(	-LRB-
cord-018764-02l423mk	286	5	HbS	HbS	NNP
cord-018764-02l423mk	286	6	)	)	-RRB-
cord-018764-02l423mk	286	7	has	have	VBZ
cord-018764-02l423mk	286	8	also	also	RB
cord-018764-02l423mk	286	9	been	be	VBN
cord-018764-02l423mk	286	10	repeatedly	repeatedly	RB
cord-018764-02l423mk	286	11	shown	show	VBN
cord-018764-02l423mk	286	12	to	to	TO
cord-018764-02l423mk	286	13	be	be	VB
cord-018764-02l423mk	286	14	associated	associate	VBN
cord-018764-02l423mk	286	15	with	with	IN
cord-018764-02l423mk	286	16	malaria	malaria	NN
cord-018764-02l423mk	286	17	resistance	resistance	NN
cord-018764-02l423mk	286	18	,	,	,
cord-018764-02l423mk	286	19	with	with	IN
cord-018764-02l423mk	286	20	heterozygotes	heterozygote	NNS
cord-018764-02l423mk	286	21	for	for	IN
cord-018764-02l423mk	286	22	the	the	DT
cord-018764-02l423mk	286	23	HbS	HbS	NNP
cord-018764-02l423mk	286	24	trait	trait	NN
cord-018764-02l423mk	286	25	demonstrating	demonstrate	VBG
cord-018764-02l423mk	286	26	10	10	CD
cord-018764-02l423mk	286	27	%	%	NN
cord-018764-02l423mk	286	28	of	of	IN
cord-018764-02l423mk	286	29	the	the	DT
cord-018764-02l423mk	286	30	population	population	NN
cord-018764-02l423mk	286	31	at	at	IN
cord-018764-02l423mk	286	32	risk	risk	NN
cord-018764-02l423mk	286	33	for	for	IN
cord-018764-02l423mk	286	34	severe	severe	JJ
cord-018764-02l423mk	286	35	malaria	malaria	NN
cord-018764-02l423mk	286	36	in	in	IN
cord-018764-02l423mk	286	37	certain	certain	JJ
cord-018764-02l423mk	286	38	populations	population	NNS
cord-018764-02l423mk	286	39	[	[	-LRB-
cord-018764-02l423mk	286	40	178	178	CD
cord-018764-02l423mk	286	41	]	]	-RRB-
cord-018764-02l423mk	286	42	.	.	.
cord-018764-02l423mk	287	1	Other	other	JJ
cord-018764-02l423mk	287	2	haemoglobinopathies	haemoglobinopathy	NNS
cord-018764-02l423mk	287	3	(	(	-LRB-
cord-018764-02l423mk	287	4	e.g.	e.g.	RB
cord-018764-02l423mk	287	5	HbC	HbC	NNP
cord-018764-02l423mk	287	6	[	[	-LRB-
cord-018764-02l423mk	287	7	179	179	CD
cord-018764-02l423mk	287	8	,	,	,
cord-018764-02l423mk	287	9	180	180	CD
cord-018764-02l423mk	287	10	]	]	-RRB-
cord-018764-02l423mk	287	11	and	and	CC
cord-018764-02l423mk	287	12	HbE	hbe	NN
cord-018764-02l423mk	287	13	[	[	-LRB-
cord-018764-02l423mk	287	14	181	181	CD
cord-018764-02l423mk	287	15	]	]	-RRB-
cord-018764-02l423mk	287	16	)	)	-RRB-
cord-018764-02l423mk	287	17	and	and	CC
cord-018764-02l423mk	287	18	deficiencies	deficiency	NNS
cord-018764-02l423mk	287	19	in	in	IN
cord-018764-02l423mk	287	20	RBC	RBC	NNP
cord-018764-02l423mk	287	21	enzymes	enzyme	NNS
cord-018764-02l423mk	287	22	(	(	-LRB-
cord-018764-02l423mk	287	23	e.g.	e.g.	RB
cord-018764-02l423mk	287	24	glucose-6-phosphate	glucose-6-phosphate	JJ
cord-018764-02l423mk	287	25	dehydrogenase	dehydrogenase	NN
cord-018764-02l423mk	287	26	deficiency	deficiency	NN
cord-018764-02l423mk	287	27	[	[	-LRB-
cord-018764-02l423mk	287	28	182	182	CD
cord-018764-02l423mk	287	29	]	]	-RRB-
cord-018764-02l423mk	287	30	)	)	-RRB-
cord-018764-02l423mk	287	31	have	have	VBP
cord-018764-02l423mk	287	32	also	also	RB
cord-018764-02l423mk	287	33	been	be	VBN
cord-018764-02l423mk	287	34	linked	link	VBN
cord-018764-02l423mk	287	35	with	with	IN
cord-018764-02l423mk	287	36	protection	protection	NN
cord-018764-02l423mk	287	37	against	against	IN
cord-018764-02l423mk	287	38	severe	severe	JJ
cord-018764-02l423mk	287	39	malaria	malaria	NN
cord-018764-02l423mk	287	40	.	.	.
cord-018764-02l423mk	288	1	The	the	DT
cord-018764-02l423mk	288	2	mechanisms	mechanism	NNS
cord-018764-02l423mk	288	3	of	of	IN
cord-018764-02l423mk	288	4	protection	protection	NN
cord-018764-02l423mk	288	5	afforded	afford	VBN
cord-018764-02l423mk	288	6	by	by	IN
cord-018764-02l423mk	288	7	haemoglobinopathies	haemoglobinopathy	NNS
cord-018764-02l423mk	288	8	are	be	VBP
cord-018764-02l423mk	288	9	likely	likely	JJ
cord-018764-02l423mk	288	10	to	to	TO
cord-018764-02l423mk	288	11	be	be	VB
cord-018764-02l423mk	288	12	multi	multi	JJ
cord-018764-02l423mk	288	13	-	-	JJ
cord-018764-02l423mk	288	14	factorial	factorial	JJ
cord-018764-02l423mk	288	15	.	.	.
cord-018764-02l423mk	289	1	Studies	study	NNS
cord-018764-02l423mk	289	2	have	have	VBP
cord-018764-02l423mk	289	3	demonstrated	demonstrate	VBN
cord-018764-02l423mk	289	4	evidence	evidence	NN
cord-018764-02l423mk	289	5	to	to	TO
cord-018764-02l423mk	289	6	support	support	VB
cord-018764-02l423mk	289	7	several	several	JJ
cord-018764-02l423mk	289	8	independent	independent	JJ
cord-018764-02l423mk	289	9	mechanisms	mechanism	NNS
cord-018764-02l423mk	289	10	including	include	VBG
cord-018764-02l423mk	289	11	:	:	:
cord-018764-02l423mk	289	12	reduced	reduce	VBN
cord-018764-02l423mk	289	13	parasite	parasite	NN
cord-018764-02l423mk	289	14	invasion	invasion	NN
cord-018764-02l423mk	289	15	of	of	IN
cord-018764-02l423mk	289	16	RBCs	rbc	NNS
cord-018764-02l423mk	289	17	and	and	CC
cord-018764-02l423mk	289	18	diminished	diminish	VBD
cord-018764-02l423mk	289	19	intraerythrocytic	intraerythrocytic	JJ
cord-018764-02l423mk	289	20	growth	growth	NN
cord-018764-02l423mk	289	21	of	of	IN
cord-018764-02l423mk	289	22	parasites	parasite	NNS
cord-018764-02l423mk	289	23	in	in	IN
cord-018764-02l423mk	289	24	patients	patient	NNS
cord-018764-02l423mk	289	25	with	with	IN
cord-018764-02l423mk	289	26	the	the	DT
cord-018764-02l423mk	289	27	HbS	hbs	JJ
cord-018764-02l423mk	289	28	trait	trait	NN
cord-018764-02l423mk	289	29	[	[	-LRB-
cord-018764-02l423mk	289	30	183	183	CD
cord-018764-02l423mk	289	31	]	]	-RRB-
cord-018764-02l423mk	289	32	,	,	,
cord-018764-02l423mk	289	33	enhanced	enhanced	JJ
cord-018764-02l423mk	289	34	phagocytosis	phagocytosis	NN
cord-018764-02l423mk	289	35	of	of	IN
cord-018764-02l423mk	289	36	parasite	parasite	NN
cord-018764-02l423mk	289	37	-	-	HYPH
cord-018764-02l423mk	289	38	infected	infect	VBN
cord-018764-02l423mk	289	39	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	289	40	(	(	-LRB-
cord-018764-02l423mk	289	41	IEs	ie	NNS
cord-018764-02l423mk	289	42	)	)	-RRB-
cord-018764-02l423mk	289	43	[	[	-LRB-
cord-018764-02l423mk	289	44	184	184	CD
cord-018764-02l423mk	289	45	]	]	-RRB-
cord-018764-02l423mk	289	46	and	and	CC
cord-018764-02l423mk	289	47	enhanced	enhance	VBD
cord-018764-02l423mk	289	48	immune	immune	JJ
cord-018764-02l423mk	289	49	responses	response	NNS
cord-018764-02l423mk	289	50	against	against	IN
cord-018764-02l423mk	289	51	IEs	ie	NNS
cord-018764-02l423mk	289	52	[	[	-LRB-
cord-018764-02l423mk	289	53	185	185	CD
cord-018764-02l423mk	289	54	]	]	-RRB-
cord-018764-02l423mk	289	55	.	.	.
cord-018764-02l423mk	290	1	Recent	recent	JJ
cord-018764-02l423mk	290	2	in	in	IN
cord-018764-02l423mk	290	3	vitro	vitro	FW
cord-018764-02l423mk	290	4	studies	study	NNS
cord-018764-02l423mk	290	5	observed	observe	VBD
cord-018764-02l423mk	290	6	that	that	IN
cord-018764-02l423mk	290	7	HbC	hbc	NN
cord-018764-02l423mk	290	8	modifies	modify	VBZ
cord-018764-02l423mk	290	9	the	the	DT
cord-018764-02l423mk	290	10	quantity	quantity	NN
cord-018764-02l423mk	290	11	and	and	CC
cord-018764-02l423mk	290	12	distribution	distribution	NN
cord-018764-02l423mk	290	13	of	of	IN
cord-018764-02l423mk	290	14	the	the	DT
cord-018764-02l423mk	290	15	variant	variant	JJ
cord-018764-02l423mk	290	16	antigen	antigen	NN
cord-018764-02l423mk	290	17	P.	p.	NN
cord-018764-02l423mk	290	18	falciparum	falciparum	NN
cord-018764-02l423mk	290	19	erythrocyte	erythrocyte	NN
cord-018764-02l423mk	290	20	membrane	membrane	NN
cord-018764-02l423mk	290	21	protein	protein	NN
cord-018764-02l423mk	290	22	1(PfEMP1	1(pfemp1	CD
cord-018764-02l423mk	290	23	)	)	-RRB-
cord-018764-02l423mk	290	24	on	on	IN
cord-018764-02l423mk	290	25	the	the	DT
cord-018764-02l423mk	290	26	IE	IE	NNP
cord-018764-02l423mk	290	27	surface	surface	NN
cord-018764-02l423mk	290	28	.	.	.
cord-018764-02l423mk	291	1	PfEMP1	PfEMP1	NNP
cord-018764-02l423mk	291	2	has	have	VBZ
cord-018764-02l423mk	291	3	been	be	VBN
cord-018764-02l423mk	291	4	implicated	implicate	VBN
cord-018764-02l423mk	291	5	in	in	IN
cord-018764-02l423mk	291	6	numerous	numerous	JJ
cord-018764-02l423mk	291	7	IE	ie	NN
cord-018764-02l423mk	291	8	adhesive	adhesive	NN
cord-018764-02l423mk	291	9	interactions	interaction	NNS
cord-018764-02l423mk	291	10	.	.	.
cord-018764-02l423mk	292	1	In	in	IN
cord-018764-02l423mk	292	2	the	the	DT
cord-018764-02l423mk	292	3	latter	latter	JJ
cord-018764-02l423mk	292	4	study	study	NN
cord-018764-02l423mk	292	5	the	the	DT
cord-018764-02l423mk	292	6	authors	author	NNS
cord-018764-02l423mk	292	7	demonstrated	demonstrate	VBD
cord-018764-02l423mk	292	8	that	that	IN
cord-018764-02l423mk	292	9	HbC	hbc	NN
cord-018764-02l423mk	292	10	reduces	reduce	VBZ
cord-018764-02l423mk	292	11	the	the	DT
cord-018764-02l423mk	292	12	level	level	NN
cord-018764-02l423mk	292	13	of	of	IN
cord-018764-02l423mk	292	14	IE	IE	NNP
cord-018764-02l423mk	292	15	adhesion	adhesion	NN
cord-018764-02l423mk	292	16	to	to	IN
cord-018764-02l423mk	292	17	endothelial	endothelial	JJ
cord-018764-02l423mk	292	18	monolayers	monolayer	NNS
cord-018764-02l423mk	292	19	,	,	,
cord-018764-02l423mk	292	20	in	in	IN
cord-018764-02l423mk	292	21	addition	addition	NN
cord-018764-02l423mk	292	22	to	to	IN
cord-018764-02l423mk	292	23	IE	IE	NNP
cord-018764-02l423mk	292	24	rosetting	rosette	VBG
cord-018764-02l423mk	292	25	(	(	-LRB-
cord-018764-02l423mk	292	26	the	the	DT
cord-018764-02l423mk	292	27	adhesion	adhesion	NN
cord-018764-02l423mk	292	28	of	of	IN
cord-018764-02l423mk	292	29	IEs	ie	NNS
cord-018764-02l423mk	292	30	to	to	IN
cord-018764-02l423mk	292	31	uninfected	uninfected	JJ
cord-018764-02l423mk	292	32	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	292	33	)	)	-RRB-
cord-018764-02l423mk	292	34	and	and	CC
cord-018764-02l423mk	292	35	IE	IE	NNP
cord-018764-02l423mk	292	36	agglutination	agglutination	NN
cord-018764-02l423mk	292	37	by	by	IN
cord-018764-02l423mk	292	38	sera	sera	NNP
cord-018764-02l423mk	292	39	.	.	.
cord-018764-02l423mk	293	1	These	these	DT
cord-018764-02l423mk	293	2	findings	finding	NNS
cord-018764-02l423mk	293	3	provide	provide	VBP
cord-018764-02l423mk	293	4	the	the	DT
cord-018764-02l423mk	293	5	prospect	prospect	NN
cord-018764-02l423mk	293	6	that	that	IN
cord-018764-02l423mk	293	7	HbC	HbC	VBD
cord-018764-02l423mk	293	8	pro	pro	JJ
cord-018764-02l423mk	293	9	-	-	JJ
cord-018764-02l423mk	293	10	tects	tect	NNS
cord-018764-02l423mk	293	11	against	against	IN
cord-018764-02l423mk	293	12	severe	severe	JJ
cord-018764-02l423mk	293	13	malaria	malaria	NN
cord-018764-02l423mk	293	14	by	by	IN
cord-018764-02l423mk	293	15	mitigating	mitigate	VBG
cord-018764-02l423mk	293	16	the	the	DT
cord-018764-02l423mk	293	17	obstruction	obstruction	NN
cord-018764-02l423mk	293	18	and	and	CC
cord-018764-02l423mk	293	19	inflammation	inflammation	NN
cord-018764-02l423mk	293	20	caused	cause	VBN
cord-018764-02l423mk	293	21	by	by	IN
cord-018764-02l423mk	293	22	the	the	DT
cord-018764-02l423mk	293	23	PfEMP1-mediated	pfemp1-mediated	JJ
cord-018764-02l423mk	293	24	adherence	adherence	NN
cord-018764-02l423mk	293	25	of	of	IN
cord-018764-02l423mk	293	26	IEs	ie	NNS
cord-018764-02l423mk	293	27	[	[	-LRB-
cord-018764-02l423mk	293	28	186	186	CD
cord-018764-02l423mk	293	29	]	]	-RRB-
cord-018764-02l423mk	293	30	.	.	.
cord-018764-02l423mk	294	1	However	however	RB
cord-018764-02l423mk	294	2	,	,	,
cord-018764-02l423mk	294	3	sequestration	sequestration	NN
cord-018764-02l423mk	294	4	is	be	VBZ
cord-018764-02l423mk	294	5	believed	believe	VBN
cord-018764-02l423mk	294	6	to	to	TO
cord-018764-02l423mk	294	7	enhance	enhance	VB
cord-018764-02l423mk	294	8	parasite	parasite	NN
cord-018764-02l423mk	294	9	survival	survival	NN
cord-018764-02l423mk	294	10	by	by	IN
cord-018764-02l423mk	294	11	enabling	enable	VBG
cord-018764-02l423mk	294	12	IEs	ie	NNS
cord-018764-02l423mk	294	13	to	to	TO
cord-018764-02l423mk	294	14	avoid	avoid	VB
cord-018764-02l423mk	294	15	splenic	splenic	JJ
cord-018764-02l423mk	294	16	clearance	clearance	NN
cord-018764-02l423mk	294	17	,	,	,
cord-018764-02l423mk	294	18	so	so	CC
cord-018764-02l423mk	294	19	any	any	DT
cord-018764-02l423mk	294	20	reduction	reduction	NN
cord-018764-02l423mk	294	21	of	of	IN
cord-018764-02l423mk	294	22	sequestration	sequestration	NN
cord-018764-02l423mk	294	23	by	by	IN
cord-018764-02l423mk	294	24	HbC	hbc	NN
cord-018764-02l423mk	294	25	can	can	MD
cord-018764-02l423mk	294	26	be	be	VB
cord-018764-02l423mk	294	27	expected	expect	VBN
cord-018764-02l423mk	294	28	to	to	TO
cord-018764-02l423mk	294	29	limit	limit	VB
cord-018764-02l423mk	294	30	parasite	parasite	NN
cord-018764-02l423mk	294	31	fitness	fitness	NN
cord-018764-02l423mk	294	32	.	.	.
cord-018764-02l423mk	295	1	Multiple	multiple	JJ
cord-018764-02l423mk	295	2	epidemiology	epidemiology	NN
cord-018764-02l423mk	295	3	studies	study	NNS
cord-018764-02l423mk	295	4	(	(	-LRB-
cord-018764-02l423mk	295	5	e.g.	e.g.	NN
cord-018764-02l423mk	295	6	[	[	-LRB-
cord-018764-02l423mk	295	7	179	179	CD
cord-018764-02l423mk	295	8	,	,	,
cord-018764-02l423mk	295	9	187	187	CD
cord-018764-02l423mk	295	10	,	,	,
cord-018764-02l423mk	295	11	188	188	CD
cord-018764-02l423mk	295	12	]	]	-RRB-
cord-018764-02l423mk	295	13	)	)	-RRB-
cord-018764-02l423mk	295	14	have	have	VBP
cord-018764-02l423mk	295	15	failed	fail	VBN
cord-018764-02l423mk	295	16	to	to	TO
cord-018764-02l423mk	295	17	identify	identify	VB
cord-018764-02l423mk	295	18	any	any	DT
cord-018764-02l423mk	295	19	significant	significant	JJ
cord-018764-02l423mk	295	20	impact	impact	NN
cord-018764-02l423mk	295	21	of	of	IN
cord-018764-02l423mk	295	22	HbC	hbc	NN
cord-018764-02l423mk	295	23	on	on	IN
cord-018764-02l423mk	295	24	the	the	DT
cord-018764-02l423mk	295	25	frequency	frequency	NN
cord-018764-02l423mk	295	26	or	or	CC
cord-018764-02l423mk	295	27	density	density	NN
cord-018764-02l423mk	295	28	of	of	IN
cord-018764-02l423mk	295	29	parasitaemia	parasitaemia	NN
cord-018764-02l423mk	295	30	in	in	IN
cord-018764-02l423mk	295	31	naturally	naturally	RB
cord-018764-02l423mk	295	32	exposed	expose	VBN
cord-018764-02l423mk	295	33	populations	population	NNS
cord-018764-02l423mk	295	34	.	.	.
cord-018764-02l423mk	296	1	Consequently	consequently	RB
cord-018764-02l423mk	296	2	,	,	,
cord-018764-02l423mk	296	3	the	the	DT
cord-018764-02l423mk	296	4	influence	influence	NN
cord-018764-02l423mk	296	5	of	of	IN
cord-018764-02l423mk	296	6	the	the	DT
cord-018764-02l423mk	296	7	changes	change	NNS
cord-018764-02l423mk	296	8	in	in	IN
cord-018764-02l423mk	296	9	IE	IE	NNP
cord-018764-02l423mk	296	10	surface	surface	NN
cord-018764-02l423mk	296	11	conformation	conformation	NN
cord-018764-02l423mk	296	12	needs	need	VBZ
cord-018764-02l423mk	296	13	to	to	TO
cord-018764-02l423mk	296	14	be	be	VB
cord-018764-02l423mk	296	15	confirmed	confirm	VBN
cord-018764-02l423mk	296	16	and	and	CC
cord-018764-02l423mk	296	17	further	further	RB
cord-018764-02l423mk	296	18	examined	examine	VBN
cord-018764-02l423mk	296	19	in	in	IN
cord-018764-02l423mk	296	20	vivo	vivo	NN
cord-018764-02l423mk	296	21	[	[	-LRB-
cord-018764-02l423mk	296	22	189	189	CD
cord-018764-02l423mk	296	23	]	]	-RRB-
cord-018764-02l423mk	296	24	.	.	.
cord-018764-02l423mk	297	1	A	a	DT
cord-018764-02l423mk	297	2	recent	recent	JJ
cord-018764-02l423mk	297	3	study	study	NN
cord-018764-02l423mk	297	4	re	re	VBN
cord-018764-02l423mk	297	5	-	-	VBN
cord-018764-02l423mk	297	6	confirmed	confirm	VBN
cord-018764-02l423mk	298	1	that	that	IN
cord-018764-02l423mk	298	2	African	african	JJ
cord-018764-02l423mk	298	3	children	child	NNS
cord-018764-02l423mk	298	4	with	with	IN
cord-018764-02l423mk	298	5	-thalassaemia	-thalassaemia	CD
cord-018764-02l423mk	298	6	trait	trait	NN
cord-018764-02l423mk	298	7	are	be	VBP
cord-018764-02l423mk	298	8	significantly	significantly	RB
cord-018764-02l423mk	298	9	less	less	RBR
cord-018764-02l423mk	298	10	likely	likely	JJ
cord-018764-02l423mk	298	11	to	to	TO
cord-018764-02l423mk	298	12	be	be	VB
cord-018764-02l423mk	298	13	hospitalised	hospitalise	VBN
cord-018764-02l423mk	298	14	with	with	IN
cord-018764-02l423mk	298	15	severe	severe	JJ
cord-018764-02l423mk	298	16	malaria	malaria	NN
cord-018764-02l423mk	298	17	,	,	,
cord-018764-02l423mk	298	18	particularly	particularly	RB
cord-018764-02l423mk	298	19	with	with	IN
cord-018764-02l423mk	298	20	coma	coma	NN
cord-018764-02l423mk	298	21	or	or	CC
cord-018764-02l423mk	298	22	severe	severe	JJ
cord-018764-02l423mk	298	23	anaemia	anaemia	NN
cord-018764-02l423mk	298	24	(	(	-LRB-
cord-018764-02l423mk	298	25	Hb	Hb	NNP
cord-018764-02l423mk	298	26	<	<	XX
cord-018764-02l423mk	298	27	5	5	CD
cord-018764-02l423mk	298	28	g/100	g/100	NNP
cord-018764-02l423mk	298	29	ml	ml	NN
cord-018764-02l423mk	298	30	)	)	-RRB-
cord-018764-02l423mk	298	31	.	.	.
cord-018764-02l423mk	299	1	It	-PRON-	PRP
cord-018764-02l423mk	299	2	is	be	VBZ
cord-018764-02l423mk	299	3	intriguing	intriguing	JJ
cord-018764-02l423mk	299	4	that	that	IN
cord-018764-02l423mk	299	5	the	the	DT
cord-018764-02l423mk	299	6	-thalassaemia	-thalassaemia	CD
cord-018764-02l423mk	299	7	patients	patient	NNS
cord-018764-02l423mk	299	8	did	do	VBD
cord-018764-02l423mk	299	9	not	not	RB
cord-018764-02l423mk	299	10	demonstrate	demonstrate	VB
cord-018764-02l423mk	299	11	a	a	DT
cord-018764-02l423mk	299	12	lower	low	JJR
cord-018764-02l423mk	299	13	incidence	incidence	NN
cord-018764-02l423mk	299	14	of	of	IN
cord-018764-02l423mk	299	15	uncomplicated	uncomplicated	JJ
cord-018764-02l423mk	299	16	malaria	malaria	NN
cord-018764-02l423mk	299	17	nor	nor	CC
cord-018764-02l423mk	299	18	any	any	DT
cord-018764-02l423mk	299	19	reduction	reduction	NN
cord-018764-02l423mk	299	20	in	in	IN
cord-018764-02l423mk	299	21	peripheral	peripheral	JJ
cord-018764-02l423mk	299	22	parasite	parasite	NN
cord-018764-02l423mk	299	23	density	density	NN
cord-018764-02l423mk	299	24	[	[	-LRB-
cord-018764-02l423mk	299	25	190	190	CD
cord-018764-02l423mk	299	26	]	]	-RRB-
cord-018764-02l423mk	299	27	.	.	.
cord-018764-02l423mk	300	1	Thalassaemia	Thalassaemia	NNP
cord-018764-02l423mk	300	2	has	have	VBZ
cord-018764-02l423mk	300	3	also	also	RB
cord-018764-02l423mk	300	4	been	be	VBN
cord-018764-02l423mk	300	5	associated	associate	VBN
cord-018764-02l423mk	300	6	with	with	IN
cord-018764-02l423mk	300	7	increased	increase	VBN
cord-018764-02l423mk	300	8	incidence	incidence	NN
cord-018764-02l423mk	300	9	of	of	IN
cord-018764-02l423mk	300	10	clinical	clinical	JJ
cord-018764-02l423mk	300	11	vivax	vivax	NN
cord-018764-02l423mk	300	12	and	and	CC
cord-018764-02l423mk	300	13	falciparum	falciparum	NN
cord-018764-02l423mk	300	14	malaria	malaria	NN
cord-018764-02l423mk	300	15	during	during	IN
cord-018764-02l423mk	300	16	early	early	JJ
cord-018764-02l423mk	300	17	life	life	NN
cord-018764-02l423mk	300	18	[	[	-LRB-
cord-018764-02l423mk	300	19	191	191	CD
cord-018764-02l423mk	300	20	]	]	-RRB-
cord-018764-02l423mk	300	21	.	.	.
cord-018764-02l423mk	301	1	The	the	DT
cord-018764-02l423mk	301	2	findings	finding	NNS
cord-018764-02l423mk	301	3	raise	raise	VBP
cord-018764-02l423mk	301	4	speculation	speculation	NN
cord-018764-02l423mk	301	5	that	that	IN
cord-018764-02l423mk	301	6	the	the	DT
cord-018764-02l423mk	301	7	trait	trait	NN
cord-018764-02l423mk	301	8	may	may	MD
cord-018764-02l423mk	301	9	indirectly	indirectly	RB
cord-018764-02l423mk	301	10	afford	afford	VB
cord-018764-02l423mk	301	11	enhanced	enhance	VBN
cord-018764-02l423mk	301	12	immunity	immunity	NN
cord-018764-02l423mk	301	13	through	through	IN
cord-018764-02l423mk	301	14	increased	increase	VBN
cord-018764-02l423mk	301	15	non	non	JJ
cord-018764-02l423mk	301	16	-	-	JJ
cord-018764-02l423mk	301	17	lethal	lethal	JJ
cord-018764-02l423mk	301	18	exposure	exposure	NN
cord-018764-02l423mk	301	19	to	to	IN
cord-018764-02l423mk	301	20	malarial	malarial	JJ
cord-018764-02l423mk	301	21	parasites	parasite	NNS
cord-018764-02l423mk	301	22	.	.	.
cord-018764-02l423mk	302	1	Such	such	JJ
cord-018764-02l423mk	302	2	a	a	DT
cord-018764-02l423mk	302	3	mechanism	mechanism	NN
cord-018764-02l423mk	302	4	is	be	VBZ
cord-018764-02l423mk	302	5	appealing	appeal	VBG
cord-018764-02l423mk	302	6	,	,	,
cord-018764-02l423mk	302	7	since	since	IN
cord-018764-02l423mk	302	8	it	-PRON-	PRP
cord-018764-02l423mk	302	9	would	would	MD
cord-018764-02l423mk	302	10	be	be	VB
cord-018764-02l423mk	302	11	equally	equally	RB
cord-018764-02l423mk	302	12	plausible	plausible	JJ
cord-018764-02l423mk	302	13	across	across	IN
cord-018764-02l423mk	302	14	a	a	DT
cord-018764-02l423mk	302	15	range	range	NN
cord-018764-02l423mk	302	16	of	of	IN
cord-018764-02l423mk	302	17	haemoglobinopathies	haemoglobinopathy	NNS
cord-018764-02l423mk	302	18	,	,	,
cord-018764-02l423mk	302	19	including	include	VBG
cord-018764-02l423mk	302	20	HbC.	HbC.	NNP
cord-018764-02l423mk	303	1	Variations	variation	NNS
cord-018764-02l423mk	303	2	in	in	IN
cord-018764-02l423mk	303	3	erythrocyte	erythrocyte	NN
cord-018764-02l423mk	303	4	membrane	membrane	NN
cord-018764-02l423mk	303	5	proteins	protein	NNS
cord-018764-02l423mk	303	6	also	also	RB
cord-018764-02l423mk	303	7	have	have	VBP
cord-018764-02l423mk	303	8	a	a	DT
cord-018764-02l423mk	303	9	profound	profound	JJ
cord-018764-02l423mk	303	10	influence	influence	NN
cord-018764-02l423mk	303	11	on	on	IN
cord-018764-02l423mk	303	12	malaria	malaria	NN
cord-018764-02l423mk	303	13	susceptibility	susceptibility	NN
cord-018764-02l423mk	303	14	.	.	.
cord-018764-02l423mk	304	1	Most	most	RBS
cord-018764-02l423mk	304	2	notably	notably	RB
cord-018764-02l423mk	304	3	the	the	DT
cord-018764-02l423mk	304	4	absence	absence	NN
cord-018764-02l423mk	304	5	of	of	IN
cord-018764-02l423mk	304	6	Duffy	Duffy	NNP
cord-018764-02l423mk	304	7	antigen	antigen	NN
cord-018764-02l423mk	304	8	protein	protein	NN
cord-018764-02l423mk	304	9	confers	confer	VBZ
cord-018764-02l423mk	304	10	absolute	absolute	JJ
cord-018764-02l423mk	304	11	protection	protection	NN
cord-018764-02l423mk	304	12	to	to	IN
cord-018764-02l423mk	304	13	P.	p.	NN
cord-018764-02l423mk	304	14	vivax	vivax	JJ
cord-018764-02l423mk	304	15	infection	infection	NN
cord-018764-02l423mk	304	16	.	.	.
cord-018764-02l423mk	305	1	More	more	RBR
cord-018764-02l423mk	305	2	recently	recently	RB
cord-018764-02l423mk	305	3	,	,	,
cord-018764-02l423mk	305	4	the	the	DT
cord-018764-02l423mk	305	5	Duffy	Duffy	NNP
cord-018764-02l423mk	305	6	antigen	antigen	NN
cord-018764-02l423mk	305	7	has	have	VBZ
cord-018764-02l423mk	305	8	also	also	RB
cord-018764-02l423mk	305	9	been	be	VBN
cord-018764-02l423mk	305	10	associated	associate	VBN
cord-018764-02l423mk	305	11	with	with	IN
cord-018764-02l423mk	305	12	a	a	DT
cord-018764-02l423mk	305	13	protection	protection	NN
cord-018764-02l423mk	305	14	against	against	IN
cord-018764-02l423mk	305	15	falciparum	falciparum	NN
cord-018764-02l423mk	305	16	malaria	malaria	NN
cord-018764-02l423mk	305	17	[	[	-LRB-
cord-018764-02l423mk	305	18	192	192	CD
cord-018764-02l423mk	305	19	]	]	-RRB-
cord-018764-02l423mk	305	20	.	.	.
cord-018764-02l423mk	306	1	Enzymes	enzyme	NNS
cord-018764-02l423mk	306	2	involved	involve	VBN
cord-018764-02l423mk	306	3	with	with	IN
cord-018764-02l423mk	306	4	iron	iron	NN
cord-018764-02l423mk	306	5	handling	handling	NN
cord-018764-02l423mk	306	6	may	may	MD
cord-018764-02l423mk	306	7	also	also	RB
cord-018764-02l423mk	306	8	have	have	VB
cord-018764-02l423mk	306	9	a	a	DT
cord-018764-02l423mk	306	10	critical	critical	JJ
cord-018764-02l423mk	306	11	influence	influence	NN
cord-018764-02l423mk	306	12	on	on	IN
cord-018764-02l423mk	306	13	malaria	malaria	NN
cord-018764-02l423mk	306	14	morbidity	morbidity	NN
cord-018764-02l423mk	306	15	.	.	.
cord-018764-02l423mk	307	1	A	a	DT
cord-018764-02l423mk	307	2	recent	recent	JJ
cord-018764-02l423mk	307	3	study	study	NN
cord-018764-02l423mk	307	4	from	from	IN
cord-018764-02l423mk	307	5	the	the	DT
cord-018764-02l423mk	307	6	Gambia	Gambia	NNP
cord-018764-02l423mk	307	7	demonstrated	demonstrate	VBD
cord-018764-02l423mk	307	8	that	that	IN
cord-018764-02l423mk	307	9	children	child	NNS
cord-018764-02l423mk	307	10	in	in	IN
cord-018764-02l423mk	307	11	an	an	DT
cord-018764-02l423mk	307	12	endemic	endemic	JJ
cord-018764-02l423mk	307	13	malaria	malaria	NN
cord-018764-02l423mk	307	14	area	area	NN
cord-018764-02l423mk	307	15	possessing	possess	VBG
cord-018764-02l423mk	307	16	the	the	DT
cord-018764-02l423mk	307	17	haptoglobin	haptoglobin	NN
cord-018764-02l423mk	307	18	2,2	2,2	CD
cord-018764-02l423mk	307	19	,	,	,
cord-018764-02l423mk	307	20	isotype	isotype	NN
cord-018764-02l423mk	307	21	had	have	VBD
cord-018764-02l423mk	307	22	a	a	DT
cord-018764-02l423mk	307	23	significantly	significantly	RB
cord-018764-02l423mk	307	24	increased	increase	VBN
cord-018764-02l423mk	307	25	risk	risk	NN
cord-018764-02l423mk	307	26	of	of	IN
cord-018764-02l423mk	307	27	anaemia	anaemia	NN
cord-018764-02l423mk	307	28	[	[	-LRB-
cord-018764-02l423mk	307	29	193	193	CD
cord-018764-02l423mk	307	30	]	]	-RRB-
cord-018764-02l423mk	307	31	.	.	.
cord-018764-02l423mk	308	1	However	however	RB
cord-018764-02l423mk	308	2	,	,	,
cord-018764-02l423mk	308	3	a	a	DT
cord-018764-02l423mk	308	4	lack	lack	NN
cord-018764-02l423mk	308	5	of	of	IN
cord-018764-02l423mk	308	6	parallel	parallel	JJ
cord-018764-02l423mk	308	7	alterations	alteration	NNS
cord-018764-02l423mk	308	8	in	in	IN
cord-018764-02l423mk	308	9	other	other	JJ
cord-018764-02l423mk	308	10	haematinic	haematinic	NNP
cord-018764-02l423mk	308	11	indices	index	NNS
cord-018764-02l423mk	308	12	leaves	leave	VBZ
cord-018764-02l423mk	308	13	the	the	DT
cord-018764-02l423mk	308	14	mechanism	mechanism	NN
cord-018764-02l423mk	308	15	of	of	IN
cord-018764-02l423mk	308	16	this	this	DT
cord-018764-02l423mk	308	17	process	process	NN
cord-018764-02l423mk	308	18	unclear	unclear	JJ
cord-018764-02l423mk	308	19	.	.	.
cord-018764-02l423mk	309	1	Malarial	malarial	JJ
cord-018764-02l423mk	309	2	protection	protection	NN
cord-018764-02l423mk	309	3	within	within	IN
cord-018764-02l423mk	309	4	individuals	individual	NNS
cord-018764-02l423mk	309	5	exhibiting	exhibit	VBG
cord-018764-02l423mk	309	6	multiple	multiple	JJ
cord-018764-02l423mk	309	7	RBC	RBC	NNP
cord-018764-02l423mk	309	8	abnormalities	abnormality	NNS
cord-018764-02l423mk	309	9	appears	appear	VBZ
cord-018764-02l423mk	309	10	even	even	RB
cord-018764-02l423mk	309	11	more	more	RBR
cord-018764-02l423mk	309	12	complex	complex	JJ
cord-018764-02l423mk	309	13	.	.	.
cord-018764-02l423mk	310	1	A	a	DT
cord-018764-02l423mk	310	2	recent	recent	JJ
cord-018764-02l423mk	310	3	study	study	NN
cord-018764-02l423mk	310	4	observed	observe	VBD
cord-018764-02l423mk	310	5	that	that	IN
cord-018764-02l423mk	310	6	the	the	DT
cord-018764-02l423mk	310	7	concurrent	concurrent	JJ
cord-018764-02l423mk	310	8	presence	presence	NN
cord-018764-02l423mk	310	9	of	of	IN
cord-018764-02l423mk	310	10	sickle	sickle	NN
cord-018764-02l423mk	310	11	cell	cell	NN
cord-018764-02l423mk	310	12	and	and	CC
cord-018764-02l423mk	310	13	-thalassaemia	-thalassaemia	CD
cord-018764-02l423mk	310	14	trait	trait	NN
cord-018764-02l423mk	310	15	among	among	IN
cord-018764-02l423mk	310	16	African	african	JJ
cord-018764-02l423mk	310	17	children	child	NNS
cord-018764-02l423mk	310	18	had	have	VBD
cord-018764-02l423mk	310	19	a	a	DT
cord-018764-02l423mk	310	20	negative	negative	JJ
cord-018764-02l423mk	310	21	influence	influence	NN
cord-018764-02l423mk	310	22	on	on	IN
cord-018764-02l423mk	310	23	the	the	DT
cord-018764-02l423mk	310	24	risk	risk	NN
cord-018764-02l423mk	310	25	of	of	IN
cord-018764-02l423mk	310	26	malaria	malaria	NN
cord-018764-02l423mk	310	27	infection	infection	NN
cord-018764-02l423mk	310	28	[	[	-LRB-
cord-018764-02l423mk	310	29	194	194	CD
cord-018764-02l423mk	310	30	]	]	-RRB-
cord-018764-02l423mk	310	31	.	.	.
cord-018764-02l423mk	311	1	The	the	DT
cord-018764-02l423mk	311	2	results	result	NNS
cord-018764-02l423mk	311	3	warn	warn	VBP
cord-018764-02l423mk	311	4	geneticists	geneticist	NNS
cord-018764-02l423mk	311	5	that	that	IN
cord-018764-02l423mk	311	6	gene	gene	NN
cord-018764-02l423mk	311	7	epistasis	epistasis	NN
cord-018764-02l423mk	311	8	may	may	MD
cord-018764-02l423mk	311	9	have	have	VB
cord-018764-02l423mk	311	10	a	a	DT
cord-018764-02l423mk	311	11	profound	profound	JJ
cord-018764-02l423mk	311	12	influence	influence	NN
cord-018764-02l423mk	311	13	on	on	IN
cord-018764-02l423mk	311	14	overall	overall	JJ
cord-018764-02l423mk	311	15	malarial	malarial	JJ
cord-018764-02l423mk	311	16	susceptibility	susceptibility	NN
cord-018764-02l423mk	311	17	.	.	.
cord-018764-02l423mk	312	1	In	in	IN
cord-018764-02l423mk	312	2	tropical	tropical	JJ
cord-018764-02l423mk	312	3	countries	country	NNS
cord-018764-02l423mk	312	4	many	many	JJ
cord-018764-02l423mk	312	5	hospital	hospital	NN
cord-018764-02l423mk	312	6	deaths	death	NNS
cord-018764-02l423mk	312	7	from	from	IN
cord-018764-02l423mk	312	8	falciparum	falciparum	NN
cord-018764-02l423mk	312	9	malaria	malaria	NN
cord-018764-02l423mk	312	10	happen	happen	VB
cord-018764-02l423mk	312	11	before	before	IN
cord-018764-02l423mk	312	12	anti	anti	JJ
cord-018764-02l423mk	312	13	-	-	JJ
cord-018764-02l423mk	312	14	malarial	malarial	JJ
cord-018764-02l423mk	312	15	drugs	drug	NNS
cord-018764-02l423mk	312	16	have	have	VBP
cord-018764-02l423mk	312	17	had	have	VBN
cord-018764-02l423mk	312	18	time	time	NN
cord-018764-02l423mk	312	19	to	to	TO
cord-018764-02l423mk	312	20	kill	kill	VB
cord-018764-02l423mk	312	21	the	the	DT
cord-018764-02l423mk	312	22	parasites	parasite	NNS
cord-018764-02l423mk	312	23	.	.	.
cord-018764-02l423mk	313	1	Two	two	CD
cord-018764-02l423mk	313	2	approaches	approach	NNS
cord-018764-02l423mk	313	3	could	could	MD
cord-018764-02l423mk	313	4	help	help	VB
cord-018764-02l423mk	313	5	rectify	rectify	VB
cord-018764-02l423mk	313	6	this	this	DT
cord-018764-02l423mk	313	7	-addressing	-addressing	JJ
cord-018764-02l423mk	313	8	public	public	JJ
cord-018764-02l423mk	313	9	-	-	HYPH
cord-018764-02l423mk	313	10	health	health	NN
cord-018764-02l423mk	313	11	problems	problem	NNS
cord-018764-02l423mk	313	12	resulting	result	VBG
cord-018764-02l423mk	313	13	in	in	IN
cord-018764-02l423mk	313	14	delayed	delayed	JJ
cord-018764-02l423mk	313	15	presentation	presentation	NN
cord-018764-02l423mk	313	16	,	,	,
cord-018764-02l423mk	313	17	and	and	CC
cord-018764-02l423mk	313	18	identifying	identify	VBG
cord-018764-02l423mk	313	19	the	the	DT
cord-018764-02l423mk	313	20	physiological	physiological	JJ
cord-018764-02l423mk	313	21	processes	process	NNS
cord-018764-02l423mk	313	22	and	and	CC
cord-018764-02l423mk	313	23	molecular	molecular	JJ
cord-018764-02l423mk	313	24	pathways	pathway	NNS
cord-018764-02l423mk	313	25	that	that	WDT
cord-018764-02l423mk	313	26	lead	lead	VBP
cord-018764-02l423mk	313	27	to	to	IN
cord-018764-02l423mk	313	28	these	these	DT
cord-018764-02l423mk	313	29	early	early	JJ
cord-018764-02l423mk	313	30	deaths	death	NNS
cord-018764-02l423mk	313	31	,	,	,
cord-018764-02l423mk	313	32	with	with	IN
cord-018764-02l423mk	313	33	a	a	DT
cord-018764-02l423mk	313	34	view	view	NN
cord-018764-02l423mk	313	35	to	to	IN
cord-018764-02l423mk	313	36	developing	develop	VBG
cord-018764-02l423mk	313	37	evidence	evidence	NN
cord-018764-02l423mk	313	38	-	-	HYPH
cord-018764-02l423mk	313	39	based	base	VBN
cord-018764-02l423mk	313	40	adjunct	adjunct	JJ
cord-018764-02l423mk	313	41	therapies	therapy	NNS
cord-018764-02l423mk	313	42	.	.	.
cord-018764-02l423mk	314	1	Therapies	therapy	NNS
cord-018764-02l423mk	314	2	being	be	VBG
cord-018764-02l423mk	314	3	explored	explore	VBN
cord-018764-02l423mk	314	4	in	in	IN
cord-018764-02l423mk	314	5	sepsis	sepsis	NN
cord-018764-02l423mk	314	6	,	,	,
cord-018764-02l423mk	314	7	and	and	CC
cord-018764-02l423mk	314	8	based	base	VBN
cord-018764-02l423mk	314	9	on	on	IN
cord-018764-02l423mk	314	10	disease	disease	NN
cord-018764-02l423mk	314	11	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	314	12	data	datum	NNS
cord-018764-02l423mk	314	13	common	common	JJ
cord-018764-02l423mk	314	14	to	to	IN
cord-018764-02l423mk	314	15	sepsis	sepsis	NN
cord-018764-02l423mk	314	16	and	and	CC
cord-018764-02l423mk	314	17	malaria	malaria	NN
cord-018764-02l423mk	314	18	,	,	,
cord-018764-02l423mk	314	19	may	may	MD
cord-018764-02l423mk	314	20	prove	prove	VB
cord-018764-02l423mk	314	21	to	to	TO
cord-018764-02l423mk	314	22	be	be	VB
cord-018764-02l423mk	314	23	transferable	transferable	JJ
cord-018764-02l423mk	314	24	from	from	IN
cord-018764-02l423mk	314	25	either	either	DT
cord-018764-02l423mk	314	26	of	of	IN
cord-018764-02l423mk	314	27	these	these	DT
cord-018764-02l423mk	314	28	diseases	disease	NNS
cord-018764-02l423mk	314	29	to	to	IN
cord-018764-02l423mk	314	30	the	the	DT
cord-018764-02l423mk	314	31	other	other	JJ
cord-018764-02l423mk	314	32	.	.	.
cord-018764-02l423mk	315	1	As	as	IN
cord-018764-02l423mk	315	2	noted	note	VBN
cord-018764-02l423mk	315	3	above	above	RB
cord-018764-02l423mk	315	4	,	,	,
cord-018764-02l423mk	315	5	circulating	circulate	VBG
cord-018764-02l423mk	315	6	levels	level	NNS
cord-018764-02l423mk	315	7	of	of	IN
cord-018764-02l423mk	315	8	a	a	DT
cord-018764-02l423mk	315	9	late	late	RB
cord-018764-02l423mk	315	10	-	-	HYPH
cord-018764-02l423mk	315	11	appearing	appear	VBG
cord-018764-02l423mk	315	12	inflammatory	inflammatory	JJ
cord-018764-02l423mk	315	13	cytokine	cytokine	NN
cord-018764-02l423mk	315	14	,	,	,
cord-018764-02l423mk	315	15	HMGB1	HMGB1	NNP
cord-018764-02l423mk	315	16	,	,	,
cord-018764-02l423mk	315	17	are	be	VBP
cord-018764-02l423mk	315	18	increased	increase	VBN
cord-018764-02l423mk	315	19	in	in	IN
cord-018764-02l423mk	315	20	falciparum	falciparum	NN
cord-018764-02l423mk	315	21	malaria	malaria	NN
cord-018764-02l423mk	315	22	[	[	-LRB-
cord-018764-02l423mk	315	23	41	41	CD
cord-018764-02l423mk	315	24	]	]	-RRB-
cord-018764-02l423mk	315	25	as	as	RB
cord-018764-02l423mk	315	26	well	well	RB
cord-018764-02l423mk	315	27	as	as	IN
cord-018764-02l423mk	315	28	in	in	IN
cord-018764-02l423mk	315	29	sepsis	sepsis	NN
cord-018764-02l423mk	315	30	.	.	.
cord-018764-02l423mk	316	1	Results	result	NNS
cord-018764-02l423mk	316	2	from	from	IN
cord-018764-02l423mk	316	3	animal	animal	NN
cord-018764-02l423mk	316	4	models	model	NNS
cord-018764-02l423mk	316	5	on	on	IN
cord-018764-02l423mk	316	6	the	the	DT
cord-018764-02l423mk	316	7	role	role	NN
cord-018764-02l423mk	316	8	of	of	IN
cord-018764-02l423mk	316	9	HMGB1	HMGB1	NNP
cord-018764-02l423mk	316	10	,	,	,
cord-018764-02l423mk	316	11	although	although	IN
cord-018764-02l423mk	316	12	untested	untested	JJ
cord-018764-02l423mk	316	13	in	in	IN
cord-018764-02l423mk	316	14	humans	human	NNS
cord-018764-02l423mk	316	15	,	,	,
cord-018764-02l423mk	316	16	have	have	VBP
cord-018764-02l423mk	316	17	inspired	inspire	VBN
cord-018764-02l423mk	316	18	enthusiasm	enthusiasm	NN
cord-018764-02l423mk	316	19	for	for	IN
cord-018764-02l423mk	316	20	inhibition	inhibition	NN
cord-018764-02l423mk	316	21	of	of	IN
cord-018764-02l423mk	316	22	this	this	DT
cord-018764-02l423mk	316	23	molecule	molecule	NN
cord-018764-02l423mk	316	24	as	as	IN
cord-018764-02l423mk	316	25	a	a	DT
cord-018764-02l423mk	316	26	potential	potential	JJ
cord-018764-02l423mk	316	27	intervention	intervention	NN
cord-018764-02l423mk	316	28	for	for	IN
cord-018764-02l423mk	316	29	human	human	JJ
cord-018764-02l423mk	316	30	sepsis	sepsis	NN
cord-018764-02l423mk	316	31	.	.	.
cord-018764-02l423mk	317	1	For	for	IN
cord-018764-02l423mk	317	2	instance	instance	NN
cord-018764-02l423mk	317	3	,	,	,
cord-018764-02l423mk	317	4	anti	anti	JJ
cord-018764-02l423mk	317	5	-	-	JJ
cord-018764-02l423mk	317	6	HMGB1	hmgb1	JJ
cord-018764-02l423mk	317	7	antibodies	antibody	NNS
cord-018764-02l423mk	317	8	provided	provide	VBD
cord-018764-02l423mk	317	9	dose	dose	NN
cord-018764-02l423mk	317	10	-	-	HYPH
cord-018764-02l423mk	317	11	dependent	dependent	JJ
cord-018764-02l423mk	317	12	protection	protection	NN
cord-018764-02l423mk	317	13	[	[	-LRB-
cord-018764-02l423mk	317	14	37	37	CD
cord-018764-02l423mk	317	15	]	]	-RRB-
cord-018764-02l423mk	317	16	and	and	CC
cord-018764-02l423mk	317	17	reduced	reduce	VBN
cord-018764-02l423mk	317	18	mortality	mortality	NN
cord-018764-02l423mk	317	19	[	[	-LRB-
cord-018764-02l423mk	317	20	195	195	CD
cord-018764-02l423mk	317	21	]	]	-RRB-
cord-018764-02l423mk	317	22	against	against	IN
cord-018764-02l423mk	317	23	experimental	experimental	JJ
cord-018764-02l423mk	317	24	sepsis	sepsis	NN
cord-018764-02l423mk	317	25	in	in	IN
cord-018764-02l423mk	317	26	mice	mouse	NNS
cord-018764-02l423mk	317	27	.	.	.
cord-018764-02l423mk	318	1	Late	late	JJ
cord-018764-02l423mk	318	2	administration	administration	NN
cord-018764-02l423mk	318	3	of	of	IN
cord-018764-02l423mk	318	4	ethyl	ethyl	NNP
cord-018764-02l423mk	318	5	pyruvate	pyruvate	NNP
cord-018764-02l423mk	318	6	,	,	,
cord-018764-02l423mk	318	7	which	which	WDT
cord-018764-02l423mk	318	8	inhibits	inhibit	VBZ
cord-018764-02l423mk	318	9	HMGB1	HMGB1	NNP
cord-018764-02l423mk	318	10	release	release	NN
cord-018764-02l423mk	318	11	from	from	IN
cord-018764-02l423mk	318	12	macrophages	macrophage	NNS
cord-018764-02l423mk	318	13	,	,	,
cord-018764-02l423mk	318	14	also	also	RB
cord-018764-02l423mk	318	15	conferred	confer	VBD
cord-018764-02l423mk	318	16	protection	protection	NN
cord-018764-02l423mk	318	17	against	against	IN
cord-018764-02l423mk	318	18	endotoxaemia	endotoxaemia	NN
cord-018764-02l423mk	318	19	in	in	IN
cord-018764-02l423mk	318	20	mice	mouse	NNS
cord-018764-02l423mk	318	21	[	[	-LRB-
cord-018764-02l423mk	318	22	196	196	CD
cord-018764-02l423mk	318	23	]	]	-RRB-
cord-018764-02l423mk	318	24	.	.	.
cord-018764-02l423mk	319	1	Treatments	treatment	NNS
cord-018764-02l423mk	319	2	directed	direct	VBN
cord-018764-02l423mk	319	3	towards	towards	IN
cord-018764-02l423mk	319	4	critical	critical	JJ
cord-018764-02l423mk	319	5	downstream	downstream	JJ
cord-018764-02l423mk	319	6	consequences	consequence	NNS
cord-018764-02l423mk	319	7	of	of	IN
cord-018764-02l423mk	319	8	malaria	malaria	NN
cord-018764-02l423mk	319	9	infection	infection	NN
cord-018764-02l423mk	319	10	and	and	CC
cord-018764-02l423mk	319	11	inflammation	inflammation	NN
cord-018764-02l423mk	319	12	,	,	,
cord-018764-02l423mk	319	13	such	such	JJ
cord-018764-02l423mk	319	14	as	as	IN
cord-018764-02l423mk	319	15	those	those	DT
cord-018764-02l423mk	319	16	intended	intend	VBN
cord-018764-02l423mk	319	17	to	to	TO
cord-018764-02l423mk	319	18	limit	limit	VB
cord-018764-02l423mk	319	19	acidosis	acidosis	NN
cord-018764-02l423mk	319	20	,	,	,
cord-018764-02l423mk	319	21	are	be	VBP
cord-018764-02l423mk	319	22	also	also	RB
cord-018764-02l423mk	319	23	a	a	DT
cord-018764-02l423mk	319	24	focus	focus	NN
cord-018764-02l423mk	319	25	of	of	IN
cord-018764-02l423mk	319	26	investigation	investigation	NN
cord-018764-02l423mk	319	27	.	.	.
cord-018764-02l423mk	320	1	One	one	CD
cord-018764-02l423mk	320	2	current	current	JJ
cord-018764-02l423mk	320	3	approach	approach	NN
cord-018764-02l423mk	320	4	is	be	VBZ
cord-018764-02l423mk	320	5	to	to	TO
cord-018764-02l423mk	320	6	identify	identify	VB
cord-018764-02l423mk	320	7	which	which	WDT
cord-018764-02l423mk	320	8	acute	acute	JJ
cord-018764-02l423mk	320	9	malaria	malaria	NN
cord-018764-02l423mk	320	10	patients	patient	NNS
cord-018764-02l423mk	320	11	most	most	JJS
cord-018764-02l423mk	320	12	benefit	benefit	VBP
cord-018764-02l423mk	320	13	from	from	IN
cord-018764-02l423mk	320	14	early	early	JJ
cord-018764-02l423mk	320	15	volume	volume	NN
cord-018764-02l423mk	320	16	expansion	expansion	NN
cord-018764-02l423mk	320	17	[	[	-LRB-
cord-018764-02l423mk	320	18	197	197	CD
cord-018764-02l423mk	320	19	]	]	-RRB-
cord-018764-02l423mk	320	20	.	.	.
cord-018764-02l423mk	321	1	Controlling	control	VBG
cord-018764-02l423mk	321	2	lactic	lactic	JJ
cord-018764-02l423mk	321	3	acidosis	acidosis	NN
cord-018764-02l423mk	321	4	via	via	IN
cord-018764-02l423mk	321	5	sodium	sodium	NN
cord-018764-02l423mk	321	6	dichloroacetate	dichloroacetate	NN
cord-018764-02l423mk	321	7	(	(	-LRB-
cord-018764-02l423mk	321	8	DCA	DCA	NNP
cord-018764-02l423mk	321	9	)	)	-RRB-
cord-018764-02l423mk	321	10	,	,	,
cord-018764-02l423mk	321	11	an	an	DT
cord-018764-02l423mk	321	12	inhibitor	inhibitor	NN
cord-018764-02l423mk	321	13	of	of	IN
cord-018764-02l423mk	321	14	pyruvate	pyruvate	NN
cord-018764-02l423mk	321	15	dehydrogenate	dehydrogenate	NNP
cord-018764-02l423mk	321	16	kinase	kinase	NN
cord-018764-02l423mk	321	17	(	(	-LRB-
cord-018764-02l423mk	321	18	maintaining	maintain	VBG
cord-018764-02l423mk	321	19	pyruvate	pyruvate	NN
cord-018764-02l423mk	321	20	dehydrogenase	dehydrogenase	NN
cord-018764-02l423mk	321	21	in	in	IN
cord-018764-02l423mk	321	22	its	-PRON-	PRP$
cord-018764-02l423mk	321	23	active	active	JJ
cord-018764-02l423mk	321	24	form	form	NN
cord-018764-02l423mk	321	25	)	)	-RRB-
cord-018764-02l423mk	321	26	,	,	,
cord-018764-02l423mk	321	27	is	be	VBZ
cord-018764-02l423mk	321	28	also	also	RB
cord-018764-02l423mk	321	29	being	be	VBG
cord-018764-02l423mk	321	30	examined	examine	VBN
cord-018764-02l423mk	321	31	.	.	.
cord-018764-02l423mk	322	1	DCA	DCA	NNP
cord-018764-02l423mk	322	2	reduced	reduce	VBD
cord-018764-02l423mk	322	3	lactate	lactate	NN
cord-018764-02l423mk	322	4	levels	level	NNS
cord-018764-02l423mk	322	5	in	in	IN
cord-018764-02l423mk	322	6	acute	acute	JJ
cord-018764-02l423mk	322	7	malaria	malaria	NN
cord-018764-02l423mk	322	8	patients	patient	NNS
cord-018764-02l423mk	322	9	[	[	-LRB-
cord-018764-02l423mk	322	10	198	198	CD
cord-018764-02l423mk	322	11	]	]	-RRB-
cord-018764-02l423mk	322	12	,	,	,
cord-018764-02l423mk	322	13	although	although	IN
cord-018764-02l423mk	322	14	the	the	DT
cord-018764-02l423mk	322	15	study	study	NN
cord-018764-02l423mk	322	16	was	be	VBD
cord-018764-02l423mk	322	17	unable	unable	JJ
cord-018764-02l423mk	322	18	to	to	TO
cord-018764-02l423mk	322	19	determine	determine	VB
cord-018764-02l423mk	322	20	whether	whether	IN
cord-018764-02l423mk	322	21	treatment	treatment	NN
cord-018764-02l423mk	322	22	improved	improve	VBN
cord-018764-02l423mk	322	23	outcome	outcome	NN
cord-018764-02l423mk	322	24	.	.	.
cord-018764-02l423mk	323	1	An	an	DT
cord-018764-02l423mk	323	2	earlier	early	JJR
cord-018764-02l423mk	323	3	large	large	JJ
cord-018764-02l423mk	323	4	sepsis	sepsis	NN
cord-018764-02l423mk	323	5	study	study	NN
cord-018764-02l423mk	323	6	also	also	RB
cord-018764-02l423mk	323	7	demonstrated	demonstrate	VBD
cord-018764-02l423mk	323	8	that	that	IN
cord-018764-02l423mk	323	9	DCA	DCA	NNP
cord-018764-02l423mk	323	10	reduced	reduce	VBN
cord-018764-02l423mk	323	11	lactate	lactate	NN
cord-018764-02l423mk	323	12	,	,	,
cord-018764-02l423mk	323	13	but	but	CC
cord-018764-02l423mk	323	14	again	again	RB
cord-018764-02l423mk	323	15	with	with	IN
cord-018764-02l423mk	323	16	no	no	DT
cord-018764-02l423mk	323	17	improvement	improvement	NN
cord-018764-02l423mk	323	18	in	in	IN
cord-018764-02l423mk	323	19	outcome	outcome	NN
cord-018764-02l423mk	323	20	[	[	-LRB-
cord-018764-02l423mk	323	21	126	126	CD
cord-018764-02l423mk	323	22	]	]	-RRB-
cord-018764-02l423mk	323	23	.	.	.
cord-018764-02l423mk	324	1	As	as	IN
cord-018764-02l423mk	324	2	outlined	outline	VBN
cord-018764-02l423mk	324	3	in	in	IN
cord-018764-02l423mk	324	4	the	the	DT
cord-018764-02l423mk	324	5	section	section	NN
cord-018764-02l423mk	324	6	'	'	``
cord-018764-02l423mk	324	7	Is	be	VBZ
cord-018764-02l423mk	324	8	hyperlactataemia	hyperlactataemia	NNP
cord-018764-02l423mk	324	9	a	a	DT
cord-018764-02l423mk	324	10	cause	cause	NN
cord-018764-02l423mk	324	11	or	or	CC
cord-018764-02l423mk	324	12	marker	marker	NN
cord-018764-02l423mk	324	13	of	of	IN
cord-018764-02l423mk	324	14	the	the	DT
cord-018764-02l423mk	324	15	acidosis	acidosis	NN
cord-018764-02l423mk	324	16	of	of	IN
cord-018764-02l423mk	324	17	malaria	malaria	NN
cord-018764-02l423mk	324	18	?	?	.
cord-018764-02l423mk	324	19	'	'	''
cord-018764-02l423mk	325	1	,	,	,
cord-018764-02l423mk	325	2	some	some	DT
cord-018764-02l423mk	325	3	researchers	researcher	NNS
cord-018764-02l423mk	325	4	argue	argue	VBP
cord-018764-02l423mk	325	5	,	,	,
cord-018764-02l423mk	325	6	in	in	IN
cord-018764-02l423mk	325	7	view	view	NN
cord-018764-02l423mk	325	8	of	of	IN
cord-018764-02l423mk	325	9	the	the	DT
cord-018764-02l423mk	325	10	strong	strong	JJ
cord-018764-02l423mk	325	11	ion	ion	NN
cord-018764-02l423mk	325	12	difference	difference	NN
cord-018764-02l423mk	325	13	contributing	contribute	VBG
cord-018764-02l423mk	325	14	to	to	IN
cord-018764-02l423mk	325	15	acidosis	acidosis	NN
cord-018764-02l423mk	325	16	and	and	CC
cord-018764-02l423mk	325	17	the	the	DT
cord-018764-02l423mk	325	18	postulated	postulate	VBN
cord-018764-02l423mk	325	19	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	325	20	dysfunction	dysfunction	NN
cord-018764-02l423mk	325	21	during	during	IN
cord-018764-02l423mk	325	22	acute	acute	JJ
cord-018764-02l423mk	325	23	malaria	malaria	NN
cord-018764-02l423mk	325	24	infection	infection	NN
cord-018764-02l423mk	325	25	,	,	,
cord-018764-02l423mk	325	26	that	that	IN
cord-018764-02l423mk	325	27	lactate	lactate	NN
cord-018764-02l423mk	325	28	reduction	reduction	NN
cord-018764-02l423mk	325	29	per	per	FW
cord-018764-02l423mk	325	30	se	se	FW
cord-018764-02l423mk	325	31	may	may	MD
cord-018764-02l423mk	325	32	have	have	VB
cord-018764-02l423mk	325	33	limited	limited	JJ
cord-018764-02l423mk	325	34	impact	impact	NN
cord-018764-02l423mk	325	35	on	on	IN
cord-018764-02l423mk	325	36	prognosis	prognosis	NN
cord-018764-02l423mk	325	37	.	.	.
cord-018764-02l423mk	326	1	Other	other	JJ
cord-018764-02l423mk	326	2	adjunct	adjunct	JJ
cord-018764-02l423mk	326	3	therapies	therapy	NNS
cord-018764-02l423mk	326	4	are	be	VBP
cord-018764-02l423mk	326	5	also	also	RB
cord-018764-02l423mk	326	6	being	be	VBG
cord-018764-02l423mk	326	7	examined	examine	VBN
cord-018764-02l423mk	326	8	.	.	.
cord-018764-02l423mk	327	1	Improving	improve	VBG
cord-018764-02l423mk	327	2	RBC	RBC	NNP
cord-018764-02l423mk	327	3	deformability	deformability	NN
cord-018764-02l423mk	327	4	provides	provide	VBZ
cord-018764-02l423mk	327	5	one	one	CD
cord-018764-02l423mk	327	6	potential	potential	JJ
cord-018764-02l423mk	327	7	therapeutic	therapeutic	JJ
cord-018764-02l423mk	327	8	approach	approach	NN
cord-018764-02l423mk	327	9	.	.	.
cord-018764-02l423mk	328	1	In	in	IN
cord-018764-02l423mk	328	2	vitro	vitro	FW
cord-018764-02l423mk	328	3	studies	study	NNS
cord-018764-02l423mk	328	4	with	with	IN
cord-018764-02l423mk	328	5	N	n	CD
cord-018764-02l423mk	328	6	-	-	HYPH
cord-018764-02l423mk	328	7	acetylcysteine	acetylcysteine	NN
cord-018764-02l423mk	328	8	(	(	-LRB-
cord-018764-02l423mk	328	9	NAC	NAC	NNP
cord-018764-02l423mk	328	10	)	)	-RRB-
cord-018764-02l423mk	328	11	,	,	,
cord-018764-02l423mk	328	12	reported	report	VBD
cord-018764-02l423mk	328	13	to	to	TO
cord-018764-02l423mk	328	14	scavenge	scavenge	VB
cord-018764-02l423mk	328	15	free	free	JJ
cord-018764-02l423mk	328	16	radicals	radical	NNS
cord-018764-02l423mk	328	17	,	,	,
cord-018764-02l423mk	328	18	showed	show	VBD
cord-018764-02l423mk	328	19	improvement	improvement	NN
cord-018764-02l423mk	328	20	in	in	IN
cord-018764-02l423mk	328	21	red	red	JJ
cord-018764-02l423mk	328	22	cell	cell	NN
cord-018764-02l423mk	328	23	deformability	deformability	NN
cord-018764-02l423mk	328	24	through	through	IN
cord-018764-02l423mk	328	25	in	in	FW
cord-018764-02l423mk	328	26	vitro	vitro	FW
cord-018764-02l423mk	328	27	studies	study	NNS
cord-018764-02l423mk	328	28	[	[	-LRB-
cord-018764-02l423mk	328	29	199	199	CD
cord-018764-02l423mk	328	30	]	]	-RRB-
cord-018764-02l423mk	328	31	.	.	.
cord-018764-02l423mk	329	1	Unfortunately	unfortunately	RB
cord-018764-02l423mk	329	2	,	,	,
cord-018764-02l423mk	329	3	an	an	DT
cord-018764-02l423mk	329	4	initial	initial	NN
cord-018764-02l423mk	329	5	in	in	IN
cord-018764-02l423mk	329	6	vivo	vivo	NN
cord-018764-02l423mk	329	7	trial	trial	NN
cord-018764-02l423mk	329	8	of	of	IN
cord-018764-02l423mk	329	9	NAC	NAC	NNP
cord-018764-02l423mk	329	10	in	in	IN
cord-018764-02l423mk	329	11	malaria	malaria	NN
cord-018764-02l423mk	329	12	patients	patient	NNS
cord-018764-02l423mk	329	13	had	have	VBD
cord-018764-02l423mk	329	14	no	no	DT
cord-018764-02l423mk	329	15	effect	effect	NN
cord-018764-02l423mk	329	16	on	on	IN
cord-018764-02l423mk	329	17	mortality	mortality	NN
cord-018764-02l423mk	329	18	[	[	-LRB-
cord-018764-02l423mk	329	19	200	200	CD
cord-018764-02l423mk	329	20	]	]	-RRB-
cord-018764-02l423mk	329	21	.	.	.
cord-018764-02l423mk	330	1	Blocking	block	VBG
cord-018764-02l423mk	330	2	endothelial	endothelial	JJ
cord-018764-02l423mk	330	3	activation	activation	NN
cord-018764-02l423mk	330	4	is	be	VBZ
cord-018764-02l423mk	330	5	also	also	RB
cord-018764-02l423mk	330	6	a	a	DT
cord-018764-02l423mk	330	7	focus	focus	NN
cord-018764-02l423mk	330	8	of	of	IN
cord-018764-02l423mk	330	9	research	research	NN
cord-018764-02l423mk	330	10	,	,	,
cord-018764-02l423mk	330	11	with	with	IN
cord-018764-02l423mk	330	12	initial	initial	JJ
cord-018764-02l423mk	330	13	in	in	FW
cord-018764-02l423mk	330	14	vitro	vitro	FW
cord-018764-02l423mk	330	15	studies	study	NNS
cord-018764-02l423mk	330	16	providing	provide	VBG
cord-018764-02l423mk	330	17	some	some	DT
cord-018764-02l423mk	330	18	encouraging	encouraging	JJ
cord-018764-02l423mk	330	19	results	result	NNS
cord-018764-02l423mk	330	20	[	[	-LRB-
cord-018764-02l423mk	330	21	201	201	CD
cord-018764-02l423mk	330	22	]	]	-RRB-
cord-018764-02l423mk	330	23	.	.	.
cord-018764-02l423mk	331	1	In	in	IN
cord-018764-02l423mk	331	2	conclusion	conclusion	NN
cord-018764-02l423mk	331	3	,	,	,
cord-018764-02l423mk	331	4	continuing	continue	VBG
cord-018764-02l423mk	331	5	to	to	TO
cord-018764-02l423mk	331	6	identify	identify	VB
cord-018764-02l423mk	331	7	the	the	DT
cord-018764-02l423mk	331	8	host	host	NN
cord-018764-02l423mk	331	9	responses	response	NNS
cord-018764-02l423mk	331	10	to	to	IN
cord-018764-02l423mk	331	11	malaria	malaria	NN
cord-018764-02l423mk	331	12	infection	infection	NN
cord-018764-02l423mk	331	13	that	that	WDT
cord-018764-02l423mk	331	14	lead	lead	VBP
cord-018764-02l423mk	331	15	to	to	IN
cord-018764-02l423mk	331	16	disease	disease	NN
cord-018764-02l423mk	331	17	is	be	VBZ
cord-018764-02l423mk	331	18	providing	provide	VBG
cord-018764-02l423mk	331	19	insights	insight	NNS
cord-018764-02l423mk	331	20	into	into	IN
cord-018764-02l423mk	331	21	novel	novel	JJ
cord-018764-02l423mk	331	22	molecular	molecular	JJ
cord-018764-02l423mk	331	23	mechanisms	mechanism	NNS
cord-018764-02l423mk	331	24	.	.	.
cord-018764-02l423mk	332	1	This	this	DT
cord-018764-02l423mk	332	2	information	information	NN
cord-018764-02l423mk	332	3	is	be	VBZ
cord-018764-02l423mk	332	4	beginning	begin	VBG
cord-018764-02l423mk	332	5	to	to	TO
cord-018764-02l423mk	332	6	guide	guide	VB
cord-018764-02l423mk	332	7	the	the	DT
cord-018764-02l423mk	332	8	design	design	NN
cord-018764-02l423mk	332	9	of	of	IN
cord-018764-02l423mk	332	10	much	much	JJ
cord-018764-02l423mk	332	11	needed	need	VBN
cord-018764-02l423mk	332	12	additional	additional	JJ
cord-018764-02l423mk	332	13	therapies	therapy	NNS
cord-018764-02l423mk	332	14	against	against	IN
cord-018764-02l423mk	332	15	this	this	DT
cord-018764-02l423mk	332	16	disease	disease	NN
cord-018764-02l423mk	332	17	.	.	.
cord-018764-02l423mk	333	1	There	there	EX
cord-018764-02l423mk	333	2	is	be	VBZ
cord-018764-02l423mk	333	3	little	little	JJ
cord-018764-02l423mk	333	4	doubt	doubt	NN
cord-018764-02l423mk	333	5	that	that	IN
cord-018764-02l423mk	333	6	poor	poor	JJ
cord-018764-02l423mk	333	7	oxygen	oxygen	NN
cord-018764-02l423mk	333	8	supply	supply	NN
cord-018764-02l423mk	333	9	through	through	IN
cord-018764-02l423mk	333	10	vascular	vascular	JJ
cord-018764-02l423mk	333	11	occlusion	occlusion	NN
cord-018764-02l423mk	333	12	or	or	CC
cord-018764-02l423mk	333	13	anaemia	anaemia	NN
cord-018764-02l423mk	333	14	could	could	MD
cord-018764-02l423mk	333	15	contribute	contribute	VB
cord-018764-02l423mk	333	16	to	to	IN
cord-018764-02l423mk	333	17	the	the	DT
cord-018764-02l423mk	333	18	body	body	NN
cord-018764-02l423mk	333	19	relying	rely	VBG
cord-018764-02l423mk	333	20	on	on	IN
cord-018764-02l423mk	333	21	excessive	excessive	JJ
cord-018764-02l423mk	333	22	glycolysis	glycolysis	NN
cord-018764-02l423mk	333	23	to	to	TO
cord-018764-02l423mk	333	24	generate	generate	VB
cord-018764-02l423mk	333	25	energy	energy	NN
cord-018764-02l423mk	333	26	,	,	,
cord-018764-02l423mk	333	27	resulting	result	VBG
cord-018764-02l423mk	333	28	in	in	IN
cord-018764-02l423mk	333	29	hyperlactataemia	hyperlactataemia	NN
cord-018764-02l423mk	333	30	,	,	,
cord-018764-02l423mk	333	31	hypoglycaemia	hypoglycaemia	NN
cord-018764-02l423mk	333	32	,	,	,
cord-018764-02l423mk	333	33	and	and	CC
cord-018764-02l423mk	333	34	metabolic	metabolic	JJ
cord-018764-02l423mk	333	35	acidosis	acidosis	NN
cord-018764-02l423mk	333	36	,	,	,
cord-018764-02l423mk	333	37	and	and	CC
cord-018764-02l423mk	333	38	altered	alter	VBN
cord-018764-02l423mk	333	39	consciousness	consciousness	NN
cord-018764-02l423mk	333	40	.	.	.
cord-018764-02l423mk	334	1	However	however	RB
cord-018764-02l423mk	334	2	,	,	,
cord-018764-02l423mk	334	3	inflammatory	inflammatory	JJ
cord-018764-02l423mk	334	4	cytokines	cytokine	NNS
cord-018764-02l423mk	334	5	control	control	VBP
cord-018764-02l423mk	334	6	these	these	DT
cord-018764-02l423mk	334	7	changes	change	NNS
cord-018764-02l423mk	334	8	,	,	,
cord-018764-02l423mk	334	9	as	as	RB
cord-018764-02l423mk	334	10	well	well	RB
cord-018764-02l423mk	334	11	as	as	IN
cord-018764-02l423mk	334	12	inhibit	inhibit	VB
cord-018764-02l423mk	334	13	the	the	DT
cord-018764-02l423mk	334	14	capacity	capacity	NN
cord-018764-02l423mk	334	15	of	of	IN
cord-018764-02l423mk	334	16	mitochondria	mitochondrion	NNS
cord-018764-02l423mk	334	17	to	to	TO
cord-018764-02l423mk	334	18	use	use	VB
cord-018764-02l423mk	334	19	oxygen	oxygen	NN
cord-018764-02l423mk	334	20	.	.	.
cord-018764-02l423mk	335	1	Thus	thus	RB
cord-018764-02l423mk	335	2	,	,	,
cord-018764-02l423mk	335	3	as	as	IN
cord-018764-02l423mk	335	4	described	describe	VBN
cord-018764-02l423mk	335	5	throughout	throughout	IN
cord-018764-02l423mk	335	6	this	this	DT
cord-018764-02l423mk	335	7	review	review	NN
cord-018764-02l423mk	335	8	,	,	,
cord-018764-02l423mk	335	9	inflammatory	inflammatory	JJ
cord-018764-02l423mk	335	10	cytokines	cytokine	NNS
cord-018764-02l423mk	335	11	are	be	VBP
cord-018764-02l423mk	335	12	likely	likely	JJ
cord-018764-02l423mk	335	13	to	to	TO
cord-018764-02l423mk	335	14	have	have	VB
cord-018764-02l423mk	335	15	various	various	JJ
cord-018764-02l423mk	335	16	pivotal	pivotal	JJ
cord-018764-02l423mk	335	17	roles	role	NNS
cord-018764-02l423mk	335	18	across	across	IN
cord-018764-02l423mk	335	19	the	the	DT
cord-018764-02l423mk	335	20	multiple	multiple	JJ
cord-018764-02l423mk	335	21	pathological	pathological	JJ
cord-018764-02l423mk	335	22	processes	process	NNS
cord-018764-02l423mk	335	23	involved	involve	VBN
cord-018764-02l423mk	335	24	in	in	IN
cord-018764-02l423mk	335	25	malarial	malarial	JJ
cord-018764-02l423mk	335	26	disease	disease	NN
cord-018764-02l423mk	335	27	(	(	-LRB-
cord-018764-02l423mk	335	28	Fig	fig	NN
cord-018764-02l423mk	335	29	.	.	.
cord-018764-02l423mk	335	30	1	1	CD
cord-018764-02l423mk	335	31	)	)	-RRB-
cord-018764-02l423mk	335	32	.	.	.
cord-018764-02l423mk	335	33	 	 	_SP
cord-018764-02l423mk	336	1	Indicators	indicator	NNS
cord-018764-02l423mk	336	2	of	of	IN
cord-018764-02l423mk	336	3	life	life	NN
cord-018764-02l423mk	336	4	-	-	HYPH
cord-018764-02l423mk	336	5	threatening	threaten	VBG
cord-018764-02l423mk	336	6	malaria	malaria	NN
cord-018764-02l423mk	336	7	in	in	IN
cord-018764-02l423mk	336	8	African	african	JJ
cord-018764-02l423mk	336	9	children	child	NNS
cord-018764-02l423mk	337	1	The	the	DT
cord-018764-02l423mk	337	2	pathophysiologic	pathophysiologic	JJ
cord-018764-02l423mk	337	3	and	and	CC
cord-018764-02l423mk	337	4	prognostic	prognostic	JJ
cord-018764-02l423mk	337	5	significance	significance	NN
cord-018764-02l423mk	337	6	of	of	IN
cord-018764-02l423mk	337	7	acidosis	acidosis	NN
cord-018764-02l423mk	337	8	in	in	IN
cord-018764-02l423mk	337	9	severe	severe	JJ
cord-018764-02l423mk	337	10	adult	adult	NN
cord-018764-02l423mk	337	11	malaria	malaria	NN
cord-018764-02l423mk	337	12	Malaria	Malaria	NNP
cord-018764-02l423mk	337	13	and	and	CC
cord-018764-02l423mk	337	14	the	the	DT
cord-018764-02l423mk	337	15	lung	lung	NN
cord-018764-02l423mk	337	16	Indicators	indicator	NNS
cord-018764-02l423mk	337	17	of	of	IN
cord-018764-02l423mk	337	18	mortality	mortality	NN
cord-018764-02l423mk	337	19	in	in	IN
cord-018764-02l423mk	337	20	African	african	JJ
cord-018764-02l423mk	337	21	adults	adult	NNS
cord-018764-02l423mk	337	22	with	with	IN
cord-018764-02l423mk	337	23	malaria	malaria	NN
cord-018764-02l423mk	337	24	Severe	severe	JJ
cord-018764-02l423mk	337	25	falciparum	falciparum	NN
cord-018764-02l423mk	337	26	malaria	malaria	NN
cord-018764-02l423mk	337	27	in	in	IN
cord-018764-02l423mk	337	28	children	child	NNS
cord-018764-02l423mk	337	29	:	:	:
cord-018764-02l423mk	337	30	current	current	JJ
cord-018764-02l423mk	337	31	understanding	understanding	NN
cord-018764-02l423mk	337	32	of	of	IN
cord-018764-02l423mk	337	33	pathophysiology	pathophysiology	NN
cord-018764-02l423mk	337	34	and	and	CC
cord-018764-02l423mk	337	35	supportive	supportive	JJ
cord-018764-02l423mk	337	36	treatment	treatment	NN
cord-018764-02l423mk	338	1	The	the	DT
cord-018764-02l423mk	338	2	injured	injured	JJ
cord-018764-02l423mk	338	3	child	child	NN
cord-018764-02l423mk	338	4	is	be	VBZ
cord-018764-02l423mk	338	5	resistant	resistant	JJ
cord-018764-02l423mk	338	6	to	to	IN
cord-018764-02l423mk	338	7	multiple	multiple	JJ
cord-018764-02l423mk	338	8	organ	organ	NN
cord-018764-02l423mk	338	9	failure	failure	NN
cord-018764-02l423mk	338	10	:	:	:
cord-018764-02l423mk	338	11	a	a	DT
cord-018764-02l423mk	338	12	different	different	JJ
cord-018764-02l423mk	338	13	inflammatory	inflammatory	JJ
cord-018764-02l423mk	338	14	response	response	NN
cord-018764-02l423mk	338	15	?	?	.
cord-018764-02l423mk	339	1	Endotoxin	endotoxin	NN
cord-018764-02l423mk	339	2	induces	induce	VBZ
cord-018764-02l423mk	339	3	an	an	DT
cord-018764-02l423mk	339	4	exaggerated	exaggerated	JJ
cord-018764-02l423mk	339	5	interleukin-10	interleukin-10	NN
cord-018764-02l423mk	339	6	response	response	NN
cord-018764-02l423mk	339	7	in	in	IN
cord-018764-02l423mk	339	8	peritoneal	peritoneal	JJ
cord-018764-02l423mk	339	9	macrophages	macrophage	NNS
cord-018764-02l423mk	339	10	of	of	IN
cord-018764-02l423mk	339	11	children	child	NNS
cord-018764-02l423mk	339	12	compared	compare	VBN
cord-018764-02l423mk	339	13	with	with	IN
cord-018764-02l423mk	339	14	adults	adult	NNS
cord-018764-02l423mk	340	1	IL-1	IL-1	NNP
cord-018764-02l423mk	340	2	beta	beta	NN
cord-018764-02l423mk	340	3	induces	induce	VBZ
cord-018764-02l423mk	340	4	an	an	DT
cord-018764-02l423mk	340	5	exaggerated	exaggerated	JJ
cord-018764-02l423mk	340	6	pro	pro	JJ
cord-018764-02l423mk	340	7	-	-	JJ
cord-018764-02l423mk	340	8	and	and	CC
cord-018764-02l423mk	340	9	anti	anti	JJ
cord-018764-02l423mk	340	10	-	-	JJ
cord-018764-02l423mk	340	11	inflammatory	inflammatory	JJ
cord-018764-02l423mk	340	12	response	response	NN
cord-018764-02l423mk	340	13	in	in	IN
cord-018764-02l423mk	340	14	peritoneal	peritoneal	JJ
cord-018764-02l423mk	340	15	macrophages	macrophage	NNS
cord-018764-02l423mk	340	16	of	of	IN
cord-018764-02l423mk	340	17	children	child	NNS
cord-018764-02l423mk	340	18	compared	compare	VBN
cord-018764-02l423mk	340	19	with	with	IN
cord-018764-02l423mk	340	20	adults	adult	NNS
cord-018764-02l423mk	340	21	Current	current	JJ
cord-018764-02l423mk	340	22	knowledge	knowledge	NN
cord-018764-02l423mk	340	23	in	in	IN
cord-018764-02l423mk	340	24	falciparum	falciparum	NN
cord-018764-02l423mk	340	25	malaria	malaria	NN
cord-018764-02l423mk	340	26	-	-	HYPH
cord-018764-02l423mk	340	27	induced	induce	VBN
cord-018764-02l423mk	340	28	acute	acute	JJ
cord-018764-02l423mk	340	29	renal	renal	JJ
cord-018764-02l423mk	340	30	failure	failure	NN
cord-018764-02l423mk	340	31	Pediatric	pediatric	JJ
cord-018764-02l423mk	340	32	considerations	consideration	NNS
cord-018764-02l423mk	340	33	Hypoglycemia	hypoglycemia	NN
cord-018764-02l423mk	340	34	in	in	IN
cord-018764-02l423mk	340	35	infancy	infancy	NN
cord-018764-02l423mk	340	36	and	and	CC
cord-018764-02l423mk	340	37	childhood	childhood	NN
cord-018764-02l423mk	340	38	Glucose	glucose	NN
cord-018764-02l423mk	340	39	production	production	NN
cord-018764-02l423mk	340	40	and	and	CC
cord-018764-02l423mk	340	41	gluconeogenesis	gluconeogenesis	NN
cord-018764-02l423mk	340	42	in	in	IN
cord-018764-02l423mk	340	43	adults	adult	NNS
cord-018764-02l423mk	340	44	with	with	IN
cord-018764-02l423mk	340	45	uncomplicated	uncomplicated	JJ
cord-018764-02l423mk	340	46	falciparum	falciparum	NN
cord-018764-02l423mk	340	47	malaria	malaria	NN
cord-018764-02l423mk	340	48	Hypoglycaemia	Hypoglycaemia	NNP
cord-018764-02l423mk	340	49	in	in	IN
cord-018764-02l423mk	340	50	African	african	JJ
cord-018764-02l423mk	340	51	children	child	NNS
cord-018764-02l423mk	340	52	with	with	IN
cord-018764-02l423mk	340	53	severe	severe	JJ
cord-018764-02l423mk	340	54	malaria	malaria	NN
cord-018764-02l423mk	340	55	Severe	severe	JJ
cord-018764-02l423mk	340	56	and	and	CC
cord-018764-02l423mk	340	57	complicated	complicated	JJ
cord-018764-02l423mk	340	58	falciparum	falciparum	NN
cord-018764-02l423mk	340	59	malaria	malaria	NN
cord-018764-02l423mk	340	60	in	in	IN
cord-018764-02l423mk	340	61	Melanesian	melanesian	JJ
cord-018764-02l423mk	340	62	adults	adult	NNS
cord-018764-02l423mk	340	63	in	in	IN
cord-018764-02l423mk	340	64	Papua	Papua	NNP
cord-018764-02l423mk	340	65	New	New	NNP
cord-018764-02l423mk	340	66	Guinea	Guinea	NNP
cord-018764-02l423mk	340	67	Cerebral	Cerebral	NNP
cord-018764-02l423mk	340	68	malaria	malaria	NN
cord-018764-02l423mk	340	69	:	:	:
cord-018764-02l423mk	340	70	the	the	DT
cord-018764-02l423mk	340	71	sequestration	sequestration	NN
cord-018764-02l423mk	340	72	hypothesis	hypothesis	NN
cord-018764-02l423mk	340	73	The	the	DT
cord-018764-02l423mk	340	74	cytokine	cytokine	NN
cord-018764-02l423mk	340	75	theory	theory	NN
cord-018764-02l423mk	340	76	of	of	IN
cord-018764-02l423mk	340	77	human	human	JJ
cord-018764-02l423mk	340	78	cerebral	cerebral	JJ
cord-018764-02l423mk	340	79	malaria	malaria	NN
cord-018764-02l423mk	340	80	Golgi	Golgi	NNP
cord-018764-02l423mk	340	81	C	C	NNP
cord-018764-02l423mk	340	82	(	(	-LRB-
cord-018764-02l423mk	340	83	1886	1886	CD
cord-018764-02l423mk	340	84	)	)	-RRB-
cord-018764-02l423mk	341	1	Sull	Sull	NNP
cord-018764-02l423mk	341	2	infezione	infezione	NN
cord-018764-02l423mk	341	3	malarica	malarica	NNP
cord-018764-02l423mk	342	1	The	the	DT
cord-018764-02l423mk	342	2	Prevention	Prevention	NNP
cord-018764-02l423mk	342	3	of	of	IN
cord-018764-02l423mk	342	4	Malaria	Malaria	NNP
cord-018764-02l423mk	343	1	Possible	possible	JJ
cord-018764-02l423mk	343	2	importance	importance	NN
cord-018764-02l423mk	343	3	of	of	IN
cord-018764-02l423mk	343	4	macrophage	macrophage	NN
cord-018764-02l423mk	343	5	-	-	HYPH
cord-018764-02l423mk	343	6	derived	derive	VBN
cord-018764-02l423mk	343	7	mediators	mediator	NNS
cord-018764-02l423mk	343	8	in	in	IN
cord-018764-02l423mk	343	9	acute	acute	JJ
cord-018764-02l423mk	343	10	malaria	malaria	NN
cord-018764-02l423mk	343	11	Evolutionary	evolutionary	JJ
cord-018764-02l423mk	343	12	causes	cause	NNS
cord-018764-02l423mk	343	13	and	and	CC
cord-018764-02l423mk	343	14	consequences	consequence	NNS
cord-018764-02l423mk	343	15	of	of	IN
cord-018764-02l423mk	343	16	immunopathology	immunopathology	NN
cord-018764-02l423mk	343	17	How	how	WRB
cord-018764-02l423mk	343	18	malaria	malaria	NN
cord-018764-02l423mk	343	19	has	have	VBZ
cord-018764-02l423mk	343	20	affected	affect	VBN
cord-018764-02l423mk	343	21	the	the	DT
cord-018764-02l423mk	343	22	human	human	JJ
cord-018764-02l423mk	343	23	genome	genome	NN
cord-018764-02l423mk	343	24	and	and	CC
cord-018764-02l423mk	343	25	what	what	WDT
cord-018764-02l423mk	343	26	human	human	JJ
cord-018764-02l423mk	343	27	genetics	genetic	NNS
cord-018764-02l423mk	343	28	can	can	MD
cord-018764-02l423mk	343	29	teach	teach	VB
cord-018764-02l423mk	343	30	us	-PRON-	PRP
cord-018764-02l423mk	343	31	about	about	IN
cord-018764-02l423mk	343	32	malaria	malaria	NN
cord-018764-02l423mk	344	1	A	a	DT
cord-018764-02l423mk	344	2	high	high	JJ
cord-018764-02l423mk	344	3	frequency	frequency	NN
cord-018764-02l423mk	344	4	African	african	JJ
cord-018764-02l423mk	344	5	coding	code	VBG
cord-018764-02l423mk	344	6	polymorphism	polymorphism	NN
cord-018764-02l423mk	344	7	in	in	IN
cord-018764-02l423mk	344	8	the	the	DT
cord-018764-02l423mk	344	9	n	n	JJ
cord-018764-02l423mk	344	10	-	-	HYPH
cord-018764-02l423mk	344	11	terminal	terminal	JJ
cord-018764-02l423mk	344	12	domain	domain	NN
cord-018764-02l423mk	344	13	of	of	IN
cord-018764-02l423mk	344	14	ICAM-1	icam-1	NN
cord-018764-02l423mk	344	15	predisposing	predispose	VBG
cord-018764-02l423mk	344	16	to	to	IN
cord-018764-02l423mk	344	17	cerebral	cerebral	JJ
cord-018764-02l423mk	344	18	malaria	malaria	NN
cord-018764-02l423mk	344	19	in	in	IN
cord-018764-02l423mk	344	20	Kenya	Kenya	NNP
cord-018764-02l423mk	344	21	Induction	Induction	NNP
cord-018764-02l423mk	344	22	of	of	IN
cord-018764-02l423mk	344	23	cachectin	cachectin	NNP
cord-018764-02l423mk	344	24	(	(	-LRB-
cord-018764-02l423mk	344	25	tumor	tumor	NN
cord-018764-02l423mk	344	26	necrosis	necrosis	NN
cord-018764-02l423mk	344	27	factor	factor	NN
cord-018764-02l423mk	344	28	)	)	-RRB-
cord-018764-02l423mk	344	29	synthesis	synthesis	NN
cord-018764-02l423mk	344	30	by	by	IN
cord-018764-02l423mk	344	31	influenza	influenza	NN
cord-018764-02l423mk	344	32	virus	virus	NN
cord-018764-02l423mk	344	33	:	:	:
cord-018764-02l423mk	344	34	deficient	deficient	JJ
cord-018764-02l423mk	344	35	production	production	NN
cord-018764-02l423mk	344	36	by	by	IN
cord-018764-02l423mk	344	37	endotoxin	endotoxin	NN
cord-018764-02l423mk	344	38	-	-	HYPH
cord-018764-02l423mk	344	39	resistant	resistant	JJ
cord-018764-02l423mk	345	1	(	(	-LRB-
cord-018764-02l423mk	345	2	C3H	C3H	NNP
cord-018764-02l423mk	345	3	/	/	SYM
cord-018764-02l423mk	345	4	HEJ	HEJ	NNP
cord-018764-02l423mk	345	5	)	)	-RRB-
cord-018764-02l423mk	345	6	macrophages	macrophage	VBZ
cord-018764-02l423mk	345	7	Induction	induction	NN
cord-018764-02l423mk	345	8	of	of	IN
cord-018764-02l423mk	345	9	proinflammatory	proinflammatory	JJ
cord-018764-02l423mk	345	10	cytokines	cytokine	NNS
cord-018764-02l423mk	345	11	in	in	IN
cord-018764-02l423mk	345	12	human	human	JJ
cord-018764-02l423mk	345	13	macrophages	macrophage	NNS
cord-018764-02l423mk	345	14	by	by	IN
cord-018764-02l423mk	345	15	influenza	influenza	NN
cord-018764-02l423mk	345	16	A	a	NN
cord-018764-02l423mk	345	17	(	(	-LRB-
cord-018764-02l423mk	345	18	H5N1	H5N1	NNP
cord-018764-02l423mk	345	19	)	)	-RRB-
cord-018764-02l423mk	345	20	viruses	virus	NNS
cord-018764-02l423mk	345	21	:	:	:
cord-018764-02l423mk	345	22	a	a	DT
cord-018764-02l423mk	345	23	mechanism	mechanism	NN
cord-018764-02l423mk	345	24	for	for	IN
cord-018764-02l423mk	345	25	the	the	DT
cord-018764-02l423mk	345	26	unusual	unusual	JJ
cord-018764-02l423mk	345	27	severity	severity	NN
cord-018764-02l423mk	345	28	of	of	IN
cord-018764-02l423mk	345	29	human	human	JJ
cord-018764-02l423mk	345	30	disease	disease	NN
cord-018764-02l423mk	345	31	Recombinant	recombinant	JJ
cord-018764-02l423mk	345	32	human	human	JJ
cord-018764-02l423mk	345	33	tumor	tumor	NN
cord-018764-02l423mk	345	34	necrosis	necrosis	NN
cord-018764-02l423mk	345	35	factor	factor	NN
cord-018764-02l423mk	345	36	administered	administer	VBN
cord-018764-02l423mk	345	37	as	as	IN
cord-018764-02l423mk	345	38	a	a	DT
cord-018764-02l423mk	345	39	24-hour	24-hour	JJ
cord-018764-02l423mk	345	40	intravenous	intravenous	JJ
cord-018764-02l423mk	345	41	infusion	infusion	NN
cord-018764-02l423mk	345	42	.	.	.
cord-018764-02l423mk	346	1	A	a	DT
cord-018764-02l423mk	346	2	phase	phase	NN
cord-018764-02l423mk	346	3	1	1	CD
cord-018764-02l423mk	346	4	and	and	CC
cord-018764-02l423mk	346	5	pharmacologic	pharmacologic	JJ
cord-018764-02l423mk	346	6	study	study	NN
cord-018764-02l423mk	346	7	Innate	innate	JJ
cord-018764-02l423mk	346	8	immunity	immunity	NN
cord-018764-02l423mk	346	9	to	to	IN
cord-018764-02l423mk	346	10	malaria	malaria	NNP
cord-018764-02l423mk	346	11	IFNGR1	IFNGR1	NNP
cord-018764-02l423mk	346	12	gene	gene	NN
cord-018764-02l423mk	346	13	promoter	promoter	NN
cord-018764-02l423mk	346	14	polymorphisms	polymorphism	NNS
cord-018764-02l423mk	346	15	and	and	CC
cord-018764-02l423mk	346	16	susceptibility	susceptibility	NN
cord-018764-02l423mk	346	17	to	to	IN
cord-018764-02l423mk	346	18	cerebral	cerebral	JJ
cord-018764-02l423mk	346	19	malaria	malaria	NN
cord-018764-02l423mk	347	1	Interferon	interferon	NN
cord-018764-02l423mk	347	2	-	-	HYPH
cord-018764-02l423mk	347	3	alpha	alpha	NN
cord-018764-02l423mk	348	1	receptor-1	receptor-1	NNP
cord-018764-02l423mk	348	2	(	(	-LRB-
cord-018764-02l423mk	348	3	IFNAR1	ifnar1	NN
cord-018764-02l423mk	348	4	)	)	-RRB-
cord-018764-02l423mk	348	5	variants	variant	NNS
cord-018764-02l423mk	348	6	are	be	VBP
cord-018764-02l423mk	348	7	associated	associate	VBN
cord-018764-02l423mk	348	8	with	with	IN
cord-018764-02l423mk	348	9	protection	protection	NN
cord-018764-02l423mk	348	10	against	against	IN
cord-018764-02l423mk	348	11	cerebral	cerebral	JJ
cord-018764-02l423mk	348	12	malaria	malaria	NN
cord-018764-02l423mk	348	13	in	in	IN
cord-018764-02l423mk	348	14	the	the	DT
cord-018764-02l423mk	348	15	Gambia	Gambia	NNP
cord-018764-02l423mk	348	16	Interleukin-1	Interleukin-1	NNP
cord-018764-02l423mk	348	17	gene	gene	NN
cord-018764-02l423mk	348	18	cluster	cluster	NN
cord-018764-02l423mk	348	19	polymorphisms	polymorphism	NNS
cord-018764-02l423mk	348	20	and	and	CC
cord-018764-02l423mk	348	21	susceptibility	susceptibility	NN
cord-018764-02l423mk	348	22	to	to	IN
cord-018764-02l423mk	348	23	clinical	clinical	JJ
cord-018764-02l423mk	348	24	malaria	malaria	NN
cord-018764-02l423mk	348	25	in	in	IN
cord-018764-02l423mk	348	26	a	a	DT
cord-018764-02l423mk	348	27	Gambian	gambian	JJ
cord-018764-02l423mk	348	28	case	case	NN
cord-018764-02l423mk	348	29	-	-	HYPH
cord-018764-02l423mk	348	30	control	control	NN
cord-018764-02l423mk	348	31	study	study	NN
cord-018764-02l423mk	348	32	Antimalarial	Antimalarial	NNP
cord-018764-02l423mk	348	33	antibody	antibody	NN
cord-018764-02l423mk	348	34	levels	level	NNS
cord-018764-02l423mk	348	35	and	and	CC
cord-018764-02l423mk	348	36	IL-4	IL-4	NNP
cord-018764-02l423mk	348	37	polymorphism	polymorphism	NN
cord-018764-02l423mk	348	38	in	in	IN
cord-018764-02l423mk	348	39	the	the	DT
cord-018764-02l423mk	348	40	Fulani	Fulani	NNP
cord-018764-02l423mk	348	41	of	of	IN
cord-018764-02l423mk	348	42	West	West	NNP
cord-018764-02l423mk	348	43	Africa	Africa	NNP
cord-018764-02l423mk	348	44	Analysis	Analysis	NNP
cord-018764-02l423mk	348	45	of	of	IN
cord-018764-02l423mk	348	46	IL10	IL10	NNP
cord-018764-02l423mk	348	47	haplotypic	haplotypic	NNP
cord-018764-02l423mk	348	48	associations	association	NNS
cord-018764-02l423mk	348	49	with	with	IN
cord-018764-02l423mk	348	50	severe	severe	JJ
cord-018764-02l423mk	348	51	malaria	malaria	NN
cord-018764-02l423mk	348	52	HMG-1	HMG-1	.
cord-018764-02l423mk	349	1	as	as	IN
cord-018764-02l423mk	349	2	a	a	DT
cord-018764-02l423mk	349	3	late	late	JJ
cord-018764-02l423mk	349	4	mediator	mediator	NN
cord-018764-02l423mk	349	5	of	of	IN
cord-018764-02l423mk	349	6	endotoxin	endotoxin	NN
cord-018764-02l423mk	349	7	lethality	lethality	NN
cord-018764-02l423mk	349	8	in	in	IN
cord-018764-02l423mk	349	9	mice	mouse	NNS
cord-018764-02l423mk	349	10	High	high	JJ
cord-018764-02l423mk	349	11	mobility	mobility	NN
cord-018764-02l423mk	349	12	group	group	NN
cord-018764-02l423mk	349	13	1	1	CD
cord-018764-02l423mk	349	14	protein	protein	NN
cord-018764-02l423mk	349	15	(	(	-LRB-
cord-018764-02l423mk	349	16	HMG-1	HMG-1	NNP
cord-018764-02l423mk	349	17	)	)	-RRB-
cord-018764-02l423mk	349	18	stimulates	stimulate	VBZ
cord-018764-02l423mk	349	19	proinflammatory	proinflammatory	JJ
cord-018764-02l423mk	349	20	cytokine	cytokine	NN
cord-018764-02l423mk	349	21	synthesis	synthesis	NN
cord-018764-02l423mk	349	22	in	in	IN
cord-018764-02l423mk	349	23	human	human	JJ
cord-018764-02l423mk	349	24	monocytes	monocyte	NNS
cord-018764-02l423mk	349	25	Ethyl	ethyl	NN
cord-018764-02l423mk	349	26	pyruvate	pyruvate	NN
cord-018764-02l423mk	349	27	protects	protect	VBZ
cord-018764-02l423mk	349	28	against	against	IN
cord-018764-02l423mk	349	29	lethal	lethal	JJ
cord-018764-02l423mk	349	30	systemic	systemic	JJ
cord-018764-02l423mk	349	31	inflammation	inflammation	NN
cord-018764-02l423mk	349	32	by	by	IN
cord-018764-02l423mk	349	33	preventing	prevent	VBG
cord-018764-02l423mk	349	34	HMGB1	HMGB1	NNP
cord-018764-02l423mk	349	35	release	release	NN
cord-018764-02l423mk	349	36	HMGB-1	HMGB-1	NNP
cord-018764-02l423mk	349	37	as	as	IN
cord-018764-02l423mk	349	38	a	a	DT
cord-018764-02l423mk	349	39	therapeutic	therapeutic	JJ
cord-018764-02l423mk	349	40	target	target	NN
cord-018764-02l423mk	349	41	for	for	IN
cord-018764-02l423mk	349	42	infectious	infectious	JJ
cord-018764-02l423mk	349	43	and	and	CC
cord-018764-02l423mk	349	44	inflammatory	inflammatory	JJ
cord-018764-02l423mk	349	45	disorders	disorder	NNS
cord-018764-02l423mk	349	46	High	high	JJ
cord-018764-02l423mk	349	47	mobility	mobility	NN
cord-018764-02l423mk	349	48	group	group	NN
cord-018764-02l423mk	349	49	box	box	NN
cord-018764-02l423mk	349	50	1	1	CD
cord-018764-02l423mk	349	51	(	(	-LRB-
cord-018764-02l423mk	349	52	HMGB1	HMGB1	NNP
cord-018764-02l423mk	349	53	)	)	-RRB-
cord-018764-02l423mk	349	54	protein	protein	NNP
cord-018764-02l423mk	349	55	:	:	:
cord-018764-02l423mk	350	1	possible	possible	JJ
cord-018764-02l423mk	350	2	amplification	amplification	NN
cord-018764-02l423mk	350	3	signal	signal	NN
cord-018764-02l423mk	350	4	in	in	IN
cord-018764-02l423mk	350	5	the	the	DT
cord-018764-02l423mk	350	6	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	350	7	of	of	IN
cord-018764-02l423mk	350	8	falciparum	falciparum	NN
cord-018764-02l423mk	350	9	malaria	malaria	NNP
cord-018764-02l423mk	350	10	Inhibition	Inhibition	NNP
cord-018764-02l423mk	350	11	of	of	IN
cord-018764-02l423mk	350	12	murine	murine	JJ
cord-018764-02l423mk	350	13	malaria	malaria	NN
cord-018764-02l423mk	350	14	(	(	-LRB-
cord-018764-02l423mk	350	15	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	350	16	chabaudi	chabaudi	NNP
cord-018764-02l423mk	350	17	)	)	-RRB-
cord-018764-02l423mk	351	1	in	in	IN
cord-018764-02l423mk	351	2	vivo	vivo	NN
cord-018764-02l423mk	351	3	by	by	IN
cord-018764-02l423mk	351	4	recombinant	recombinant	JJ
cord-018764-02l423mk	351	5	interferon	interferon	NN
cord-018764-02l423mk	351	6	-	-	HYPH
cord-018764-02l423mk	351	7	gamma	gamma	NN
cord-018764-02l423mk	351	8	or	or	CC
cord-018764-02l423mk	351	9	tumor	tumor	NN
cord-018764-02l423mk	351	10	necrosis	necrosis	NN
cord-018764-02l423mk	351	11	factor	factor	NN
cord-018764-02l423mk	351	12	,	,	,
cord-018764-02l423mk	351	13	and	and	CC
cord-018764-02l423mk	351	14	its	-PRON-	PRP$
cord-018764-02l423mk	351	15	enhancement	enhancement	NN
cord-018764-02l423mk	351	16	by	by	IN
cord-018764-02l423mk	351	17	butylated	butylate	VBN
cord-018764-02l423mk	351	18	hydroxyanisole	hydroxyanisole	NNP
cord-018764-02l423mk	351	19	Killing	kill	VBG
cord-018764-02l423mk	351	20	of	of	IN
cord-018764-02l423mk	351	21	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	351	22	falciparum	falciparum	NNS
cord-018764-02l423mk	351	23	in	in	IN
cord-018764-02l423mk	351	24	vitro	vitro	FW
cord-018764-02l423mk	351	25	by	by	IN
cord-018764-02l423mk	351	26	nitric	nitric	JJ
cord-018764-02l423mk	351	27	oxide	oxide	NN
cord-018764-02l423mk	351	28	derivatives	derivative	NNS
cord-018764-02l423mk	351	29	Influence	influence	NN
cord-018764-02l423mk	351	30	of	of	IN
cord-018764-02l423mk	351	31	tumor	tumor	NN
cord-018764-02l423mk	351	32	necrosis	necrosis	NN
cord-018764-02l423mk	351	33	factor	factor	NN
cord-018764-02l423mk	351	34	-	-	HYPH
cord-018764-02l423mk	351	35	alpha	alpha	NN
cord-018764-02l423mk	351	36	on	on	IN
cord-018764-02l423mk	351	37	the	the	DT
cord-018764-02l423mk	351	38	ability	ability	NN
cord-018764-02l423mk	351	39	of	of	IN
cord-018764-02l423mk	351	40	monocytes	monocyte	NNS
cord-018764-02l423mk	351	41	and	and	CC
cord-018764-02l423mk	351	42	lymphocytes	lymphocyte	NNS
cord-018764-02l423mk	351	43	to	to	TO
cord-018764-02l423mk	351	44	destroy	destroy	VB
cord-018764-02l423mk	351	45	intraerythrocytic	intraerythrocytic	JJ
cord-018764-02l423mk	351	46	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	351	47	falciparum	falciparum	NN
cord-018764-02l423mk	351	48	in	in	IN
cord-018764-02l423mk	351	49	vitro	vitro	FW
cord-018764-02l423mk	351	50	Immunity	immunity	NN
cord-018764-02l423mk	351	51	to	to	IN
cord-018764-02l423mk	351	52	malaria	malaria	NN
cord-018764-02l423mk	351	53	after	after	IN
cord-018764-02l423mk	351	54	administration	administration	NN
cord-018764-02l423mk	351	55	of	of	IN
cord-018764-02l423mk	351	56	ultra	ultra	JJ
cord-018764-02l423mk	351	57	-	-	JJ
cord-018764-02l423mk	351	58	low	low	JJ
cord-018764-02l423mk	351	59	doses	dose	NNS
cord-018764-02l423mk	351	60	of	of	IN
cord-018764-02l423mk	351	61	red	red	JJ
cord-018764-02l423mk	351	62	cells	cell	NNS
cord-018764-02l423mk	351	63	infected	infect	VBN
cord-018764-02l423mk	351	64	with	with	IN
cord-018764-02l423mk	351	65	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	351	66	falciparum	falciparum	NN
cord-018764-02l423mk	352	1	The	the	DT
cord-018764-02l423mk	352	2	effect	effect	NN
cord-018764-02l423mk	352	3	of	of	IN
cord-018764-02l423mk	352	4	a	a	DT
cord-018764-02l423mk	352	5	monoclonal	monoclonal	JJ
cord-018764-02l423mk	352	6	antibody	antibody	NN
cord-018764-02l423mk	352	7	to	to	TO
cord-018764-02l423mk	352	8	tumor	tumor	NN
cord-018764-02l423mk	352	9	necrosis	necrosis	NN
cord-018764-02l423mk	352	10	factor	factor	NN
cord-018764-02l423mk	352	11	on	on	IN
cord-018764-02l423mk	352	12	survival	survival	NN
cord-018764-02l423mk	352	13	from	from	IN
cord-018764-02l423mk	352	14	childhood	childhood	NN
cord-018764-02l423mk	352	15	cerebral	cerebral	JJ
cord-018764-02l423mk	352	16	malaria	malaria	NN
cord-018764-02l423mk	352	17	Treatment	treatment	NN
cord-018764-02l423mk	352	18	of	of	IN
cord-018764-02l423mk	352	19	septic	septic	JJ
cord-018764-02l423mk	352	20	shock	shock	NN
cord-018764-02l423mk	352	21	with	with	IN
cord-018764-02l423mk	352	22	the	the	DT
cord-018764-02l423mk	352	23	tumor	tumor	NN
cord-018764-02l423mk	352	24	necrosis	necrosis	NN
cord-018764-02l423mk	352	25	factor	factor	NN
cord-018764-02l423mk	352	26	receptor	receptor	NN
cord-018764-02l423mk	352	27	:	:	:
cord-018764-02l423mk	353	1	Fc	Fc	NNP
cord-018764-02l423mk	353	2	fusion	fusion	NN
cord-018764-02l423mk	353	3	protein	protein	NN
cord-018764-02l423mk	353	4	Disease	Disease	NNP
cord-018764-02l423mk	353	5	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	353	6	in	in	IN
cord-018764-02l423mk	353	7	malaria	malaria	NN
cord-018764-02l423mk	353	8	and	and	CC
cord-018764-02l423mk	353	9	clinically	clinically	RB
cord-018764-02l423mk	353	10	similar	similar	JJ
cord-018764-02l423mk	353	11	conditions	condition	NNS
cord-018764-02l423mk	353	12	Tumour	tumour	NN
cord-018764-02l423mk	353	13	necrosis	necrosis	NN
cord-018764-02l423mk	353	14	factor	factor	NN
cord-018764-02l423mk	353	15	and	and	CC
cord-018764-02l423mk	353	16	related	related	JJ
cord-018764-02l423mk	353	17	cytokines	cytokine	NNS
cord-018764-02l423mk	354	1	A	a	DT
cord-018764-02l423mk	354	2	phase	phase	NN
cord-018764-02l423mk	354	3	1	1	CD
cord-018764-02l423mk	354	4	clinical	clinical	JJ
cord-018764-02l423mk	354	5	trial	trial	NN
cord-018764-02l423mk	354	6	of	of	IN
cord-018764-02l423mk	354	7	recombinant	recombinant	JJ
cord-018764-02l423mk	354	8	human	human	JJ
cord-018764-02l423mk	354	9	tumor	tumor	NN
cord-018764-02l423mk	354	10	necrosis	necrosis	NN
cord-018764-02l423mk	354	11	factor	factor	NN
cord-018764-02l423mk	354	12	Clinical	clinical	JJ
cord-018764-02l423mk	354	13	features	feature	NNS
cord-018764-02l423mk	354	14	can	can	MD
cord-018764-02l423mk	354	15	not	not	RB
cord-018764-02l423mk	354	16	predict	predict	VB
cord-018764-02l423mk	354	17	a	a	DT
cord-018764-02l423mk	354	18	diagnosis	diagnosis	NN
cord-018764-02l423mk	354	19	of	of	IN
cord-018764-02l423mk	354	20	malaria	malaria	NN
cord-018764-02l423mk	354	21	or	or	CC
cord-018764-02l423mk	354	22	differentiate	differentiate	VB
cord-018764-02l423mk	354	23	the	the	DT
cord-018764-02l423mk	354	24	infecting	infect	VBG
cord-018764-02l423mk	354	25	species	specie	NNS
cord-018764-02l423mk	354	26	in	in	IN
cord-018764-02l423mk	354	27	children	child	NNS
cord-018764-02l423mk	354	28	living	live	VBG
cord-018764-02l423mk	354	29	in	in	IN
cord-018764-02l423mk	354	30	an	an	DT
cord-018764-02l423mk	354	31	area	area	NN
cord-018764-02l423mk	354	32	of	of	IN
cord-018764-02l423mk	354	33	low	low	JJ
cord-018764-02l423mk	354	34	transmission	transmission	NN
cord-018764-02l423mk	355	1	A	a	DT
cord-018764-02l423mk	355	2	human	human	JJ
cord-018764-02l423mk	355	3	88-kD	88-kd	CD
cord-018764-02l423mk	355	4	membrane	membrane	NN
cord-018764-02l423mk	355	5	glycoprotein	glycoprotein	NN
cord-018764-02l423mk	355	6	(	(	-LRB-
cord-018764-02l423mk	355	7	CD36	CD36	NNP
cord-018764-02l423mk	355	8	)	)	-RRB-
cord-018764-02l423mk	355	9	functions	function	NNS
cord-018764-02l423mk	355	10	in	in	IN
cord-018764-02l423mk	355	11	vitro	vitro	FW
cord-018764-02l423mk	355	12	as	as	IN
cord-018764-02l423mk	355	13	a	a	DT
cord-018764-02l423mk	355	14	receptor	receptor	NN
cord-018764-02l423mk	355	15	for	for	IN
cord-018764-02l423mk	355	16	a	a	DT
cord-018764-02l423mk	355	17	cytoadherence	cytoadherence	NN
cord-018764-02l423mk	355	18	ligand	ligand	NN
cord-018764-02l423mk	355	19	on	on	IN
cord-018764-02l423mk	355	20	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	355	21	falciparum	falciparum	NN
cord-018764-02l423mk	355	22	-	-	HYPH
cord-018764-02l423mk	355	23	infected	infect	VBN
cord-018764-02l423mk	355	24	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	356	1	Thrombospondin	Thrombospondin	NNP
cord-018764-02l423mk	356	2	binds	bind	VBZ
cord-018764-02l423mk	356	3	falciparum	falciparum	NN
cord-018764-02l423mk	356	4	malaria	malaria	NN
cord-018764-02l423mk	356	5	parasitized	parasitize	VBN
cord-018764-02l423mk	356	6	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	356	7	and	and	CC
cord-018764-02l423mk	356	8	may	may	MD
cord-018764-02l423mk	356	9	mediate	mediate	VB
cord-018764-02l423mk	356	10	cytoadherence	cytoadherence	NN
cord-018764-02l423mk	356	11	Receptor	receptor	NN
cord-018764-02l423mk	356	12	-	-	HYPH
cord-018764-02l423mk	356	13	specific	specific	JJ
cord-018764-02l423mk	356	14	adhesion	adhesion	NN
cord-018764-02l423mk	356	15	and	and	CC
cord-018764-02l423mk	356	16	clinical	clinical	JJ
cord-018764-02l423mk	356	17	disease	disease	NN
cord-018764-02l423mk	356	18	in	in	IN
cord-018764-02l423mk	356	19	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	356	20	falciparum	falciparum	NN
cord-018764-02l423mk	356	21	Intercellular	Intercellular	NNP
cord-018764-02l423mk	356	22	adhesion	adhesion	NN
cord-018764-02l423mk	357	1	molecule-1	molecule-1	NNP
cord-018764-02l423mk	357	2	is	be	VBZ
cord-018764-02l423mk	357	3	an	an	DT
cord-018764-02l423mk	357	4	endothelial	endothelial	JJ
cord-018764-02l423mk	357	5	cell	cell	NN
cord-018764-02l423mk	357	6	adhesion	adhesion	NN
cord-018764-02l423mk	357	7	receptor	receptor	NN
cord-018764-02l423mk	357	8	for	for	IN
cord-018764-02l423mk	357	9	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	357	10	falciparum	falciparum	NN
cord-018764-02l423mk	357	11	Human	human	JJ
cord-018764-02l423mk	357	12	vascular	vascular	JJ
cord-018764-02l423mk	357	13	endothelial	endothelial	JJ
cord-018764-02l423mk	357	14	cell	cell	NN
cord-018764-02l423mk	357	15	adhesion	adhesion	NN
cord-018764-02l423mk	357	16	receptors	receptor	NNS
cord-018764-02l423mk	357	17	for	for	IN
cord-018764-02l423mk	357	18	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	357	19	falciparum	falciparum	NN
cord-018764-02l423mk	357	20	-	-	HYPH
cord-018764-02l423mk	357	21	infected	infect	VBN
cord-018764-02l423mk	357	22	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	357	23	:	:	:
cord-018764-02l423mk	358	1	roles	role	NNS
cord-018764-02l423mk	358	2	for	for	IN
cord-018764-02l423mk	358	3	endothelial	endothelial	JJ
cord-018764-02l423mk	358	4	leukocyte	leukocyte	NN
cord-018764-02l423mk	358	5	adhesion	adhesion	NN
cord-018764-02l423mk	358	6	molecule	molecule	NN
cord-018764-02l423mk	358	7	1	1	CD
cord-018764-02l423mk	358	8	and	and	CC
cord-018764-02l423mk	358	9	vascular	vascular	JJ
cord-018764-02l423mk	358	10	cell	cell	NN
cord-018764-02l423mk	358	11	adhesion	adhesion	NN
cord-018764-02l423mk	358	12	molecule	molecule	NN
cord-018764-02l423mk	358	13	1	1	CD
cord-018764-02l423mk	358	14	Human	Human	NNP
cord-018764-02l423mk	358	15	cerebral	cerebral	JJ
cord-018764-02l423mk	358	16	malaria	malaria	NN
cord-018764-02l423mk	358	17	:	:	:
cord-018764-02l423mk	358	18	associated	associate	VBN
cord-018764-02l423mk	358	19	with	with	IN
cord-018764-02l423mk	358	20	erythrocyte	erythrocyte	NN
cord-018764-02l423mk	358	21	rosetting	rosetting	NN
cord-018764-02l423mk	358	22	and	and	CC
cord-018764-02l423mk	358	23	lack	lack	NN
cord-018764-02l423mk	358	24	of	of	IN
cord-018764-02l423mk	358	25	anti	anti	JJ
cord-018764-02l423mk	358	26	-	-	JJ
cord-018764-02l423mk	358	27	rosetting	rosetting	JJ
cord-018764-02l423mk	358	28	antibodies	antibody	NNS
cord-018764-02l423mk	358	29	Platelet	platelet	NN
cord-018764-02l423mk	358	30	-	-	HYPH
cord-018764-02l423mk	358	31	mediated	mediate	VBN
cord-018764-02l423mk	358	32	clumping	clumping	NN
cord-018764-02l423mk	358	33	of	of	IN
cord-018764-02l423mk	358	34	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	358	35	falciparum	falciparum	NN
cord-018764-02l423mk	358	36	-	-	HYPH
cord-018764-02l423mk	358	37	infected	infect	VBN
cord-018764-02l423mk	358	38	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	358	39	is	be	VBZ
cord-018764-02l423mk	358	40	a	a	DT
cord-018764-02l423mk	358	41	common	common	JJ
cord-018764-02l423mk	358	42	adhesive	adhesive	NN
cord-018764-02l423mk	358	43	phonotype	phonotype	NN
cord-018764-02l423mk	358	44	and	and	CC
cord-018764-02l423mk	358	45	is	be	VBZ
cord-018764-02l423mk	358	46	associated	associate	VBN
cord-018764-02l423mk	358	47	with	with	IN
cord-018764-02l423mk	358	48	severe	severe	JJ
cord-018764-02l423mk	358	49	malaria	malaria	NN
cord-018764-02l423mk	359	1	A	a	DT
cord-018764-02l423mk	359	2	non	non	JJ
cord-018764-02l423mk	359	3	-	-	JJ
cord-018764-02l423mk	359	4	sense	sense	JJ
cord-018764-02l423mk	359	5	mutation	mutation	NN
cord-018764-02l423mk	359	6	in	in	IN
cord-018764-02l423mk	359	7	Cd36	Cd36	NNP
cord-018764-02l423mk	360	1	gene	gene	NN
cord-018764-02l423mk	360	2	is	be	VBZ
cord-018764-02l423mk	360	3	associated	associate	VBN
cord-018764-02l423mk	360	4	with	with	IN
cord-018764-02l423mk	360	5	protection	protection	NN
cord-018764-02l423mk	360	6	from	from	IN
cord-018764-02l423mk	360	7	severe	severe	JJ
cord-018764-02l423mk	360	8	malaria	malaria	NN
cord-018764-02l423mk	360	9	Increased	increase	VBN
cord-018764-02l423mk	360	10	plasma	plasma	NN
cord-018764-02l423mk	360	11	concentrations	concentration	NNS
cord-018764-02l423mk	360	12	of	of	IN
cord-018764-02l423mk	360	13	sICAM-1	sICAM-1	NNP
cord-018764-02l423mk	360	14	,	,	,
cord-018764-02l423mk	360	15	sVCAM-1	sVCAM-1	NNP
cord-018764-02l423mk	360	16	and	and	CC
cord-018764-02l423mk	360	17	sELAM-1	sELAM-1	NNP
cord-018764-02l423mk	360	18	in	in	IN
cord-018764-02l423mk	360	19	patients	patient	NNS
cord-018764-02l423mk	360	20	with	with	IN
cord-018764-02l423mk	360	21	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	360	22	falciparum	falciparum	NNS
cord-018764-02l423mk	360	23	or	or	CC
cord-018764-02l423mk	360	24	P.	p.	NN
cord-018764-02l423mk	360	25	vivax	vivax	JJ
cord-018764-02l423mk	360	26	malaria	malaria	NN
cord-018764-02l423mk	360	27	and	and	CC
cord-018764-02l423mk	360	28	association	association	NN
cord-018764-02l423mk	360	29	with	with	IN
cord-018764-02l423mk	360	30	disease	disease	NNP
cord-018764-02l423mk	360	31	severity	severity	NN
cord-018764-02l423mk	361	1	Possible	possible	JJ
cord-018764-02l423mk	361	2	involvement	involvement	NN
cord-018764-02l423mk	361	3	of	of	IN
cord-018764-02l423mk	361	4	cytokines	cytokine	NNS
cord-018764-02l423mk	361	5	in	in	IN
cord-018764-02l423mk	361	6	diffuse	diffuse	JJ
cord-018764-02l423mk	361	7	intravascular	intravascular	JJ
cord-018764-02l423mk	361	8	coagulation	coagulation	NN
cord-018764-02l423mk	361	9	and	and	CC
cord-018764-02l423mk	361	10	thrombosis	thrombosis	NN
cord-018764-02l423mk	361	11	Tissue	tissue	NN
cord-018764-02l423mk	361	12	factor	factor	NN
cord-018764-02l423mk	361	13	in	in	IN
cord-018764-02l423mk	361	14	infection	infection	NN
cord-018764-02l423mk	361	15	and	and	CC
cord-018764-02l423mk	361	16	severe	severe	JJ
cord-018764-02l423mk	361	17	inflammation	inflammation	NN
cord-018764-02l423mk	361	18	Transcriptional	transcriptional	JJ
cord-018764-02l423mk	361	19	expression	expression	NN
cord-018764-02l423mk	361	20	of	of	IN
cord-018764-02l423mk	361	21	tissue	tissue	NN
cord-018764-02l423mk	361	22	factor	factor	NN
cord-018764-02l423mk	361	23	pathway	pathway	NN
cord-018764-02l423mk	361	24	inhibitor	inhibitor	NN
cord-018764-02l423mk	361	25	,	,	,
cord-018764-02l423mk	361	26	thrombomodulin	thrombomodulin	NNP
cord-018764-02l423mk	361	27	and	and	CC
cord-018764-02l423mk	361	28	von	von	NNP
cord-018764-02l423mk	361	29	Willebrand	Willebrand	NNP
cord-018764-02l423mk	361	30	factor	factor	NN
cord-018764-02l423mk	361	31	in	in	IN
cord-018764-02l423mk	361	32	normal	normal	JJ
cord-018764-02l423mk	361	33	human	human	JJ
cord-018764-02l423mk	361	34	tissues	tissue	NNS
cord-018764-02l423mk	362	1	Thrombin	Thrombin	NNP
cord-018764-02l423mk	362	2	-	-	HYPH
cord-018764-02l423mk	362	3	activated	activate	VBN
cord-018764-02l423mk	362	4	human	human	JJ
cord-018764-02l423mk	362	5	endothelial	endothelial	JJ
cord-018764-02l423mk	362	6	cells	cell	NNS
cord-018764-02l423mk	362	7	support	support	VBP
cord-018764-02l423mk	362	8	monocyte	monocyte	NNP
cord-018764-02l423mk	362	9	adhesion	adhesion	NN
cord-018764-02l423mk	362	10	in	in	IN
cord-018764-02l423mk	362	11	vitro	vitro	FW
cord-018764-02l423mk	362	12	following	follow	VBG
cord-018764-02l423mk	362	13	expression	expression	NN
cord-018764-02l423mk	362	14	of	of	IN
cord-018764-02l423mk	362	15	intercellular	intercellular	JJ
cord-018764-02l423mk	362	16	adhesion	adhesion	NN
cord-018764-02l423mk	362	17	molecule-1	molecule-1	NN
cord-018764-02l423mk	363	1	(	(	-LRB-
cord-018764-02l423mk	363	2	ICAM-1	ICAM-1	NNP
cord-018764-02l423mk	363	3	CD54	CD54	NNP
cord-018764-02l423mk	363	4	)	)	-RRB-
cord-018764-02l423mk	363	5	and	and	CC
cord-018764-02l423mk	363	6	vascular	vascular	JJ
cord-018764-02l423mk	363	7	cell	cell	NN
cord-018764-02l423mk	363	8	adhesion	adhesion	NN
cord-018764-02l423mk	363	9	molecule-1	molecule-1	NNP
cord-018764-02l423mk	364	1	(	(	-LRB-
cord-018764-02l423mk	364	2	VCAM-1	VCAM-1	NNP
cord-018764-02l423mk	364	3	CD106	CD106	NNP
cord-018764-02l423mk	364	4	)	)	-RRB-
cord-018764-02l423mk	364	5	Thrombin	Thrombin	NNP
cord-018764-02l423mk	364	6	stimulates	stimulate	VBZ
cord-018764-02l423mk	364	7	proliferation	proliferation	NN
cord-018764-02l423mk	364	8	of	of	IN
cord-018764-02l423mk	364	9	liver	liver	NN
cord-018764-02l423mk	364	10	fat	fat	NN
cord-018764-02l423mk	364	11	-	-	HYPH
cord-018764-02l423mk	364	12	storing	store	VBG
cord-018764-02l423mk	364	13	cells	cell	NNS
cord-018764-02l423mk	364	14	and	and	CC
cord-018764-02l423mk	364	15	expression	expression	NN
cord-018764-02l423mk	364	16	of	of	IN
cord-018764-02l423mk	364	17	monocyte	monocyte	NNP
cord-018764-02l423mk	364	18	chemotactic	chemotactic	JJ
cord-018764-02l423mk	364	19	protein-1	protein-1	NNP
cord-018764-02l423mk	364	20	:	:	:
cord-018764-02l423mk	364	21	potential	potential	JJ
cord-018764-02l423mk	364	22	role	role	NN
cord-018764-02l423mk	364	23	in	in	IN
cord-018764-02l423mk	364	24	liver	liver	NN
cord-018764-02l423mk	364	25	injury	injury	NN
cord-018764-02l423mk	365	1	Lactic	lactic	JJ
cord-018764-02l423mk	365	2	acidosis	acidosis	NN
cord-018764-02l423mk	365	3	and	and	CC
cord-018764-02l423mk	365	4	oxygen	oxygen	NN
cord-018764-02l423mk	365	5	debt	debt	NN
cord-018764-02l423mk	365	6	in	in	IN
cord-018764-02l423mk	365	7	African	african	JJ
cord-018764-02l423mk	365	8	children	child	NNS
cord-018764-02l423mk	365	9	with	with	IN
cord-018764-02l423mk	365	10	severe	severe	JJ
cord-018764-02l423mk	365	11	anaemia	anaemia	NN
cord-018764-02l423mk	365	12	Red	red	JJ
cord-018764-02l423mk	365	13	blood	blood	NN
cord-018764-02l423mk	365	14	cell	cell	NN
cord-018764-02l423mk	365	15	physiology	physiology	NN
cord-018764-02l423mk	365	16	in	in	IN
cord-018764-02l423mk	365	17	critical	critical	JJ
cord-018764-02l423mk	365	18	illness	illness	NN
cord-018764-02l423mk	365	19	Anaemia	anaemia	NN
cord-018764-02l423mk	365	20	and	and	CC
cord-018764-02l423mk	365	21	resistance	resistance	NN
cord-018764-02l423mk	365	22	to	to	IN
cord-018764-02l423mk	365	23	malaria	malaria	NN
cord-018764-02l423mk	365	24	in	in	IN
cord-018764-02l423mk	365	25	transgenic	transgenic	JJ
cord-018764-02l423mk	365	26	mice	mouse	NNS
cord-018764-02l423mk	365	27	expressing	express	VBG
cord-018764-02l423mk	365	28	human	human	JJ
cord-018764-02l423mk	365	29	tumour	tumour	NN
cord-018764-02l423mk	365	30	necrosis	necrosis	NN
cord-018764-02l423mk	365	31	factor	factor	NN
cord-018764-02l423mk	365	32	Physiological	physiological	JJ
cord-018764-02l423mk	365	33	studies	study	NNS
cord-018764-02l423mk	365	34	in	in	IN
cord-018764-02l423mk	365	35	the	the	DT
cord-018764-02l423mk	365	36	human	human	JJ
cord-018764-02l423mk	365	37	malarial	malarial	JJ
cord-018764-02l423mk	365	38	host	host	NN
cord-018764-02l423mk	365	39	Alterations	alteration	NNS
cord-018764-02l423mk	365	40	in	in	IN
cord-018764-02l423mk	365	41	red	red	JJ
cord-018764-02l423mk	365	42	blood	blood	NN
cord-018764-02l423mk	365	43	cell	cell	NN
cord-018764-02l423mk	365	44	sodium	sodium	NN
cord-018764-02l423mk	365	45	transport	transport	NN
cord-018764-02l423mk	365	46	during	during	IN
cord-018764-02l423mk	365	47	malaria	malaria	NN
cord-018764-02l423mk	365	48	Changes	change	NNS
cord-018764-02l423mk	365	49	in	in	IN
cord-018764-02l423mk	365	50	sodium	sodium	NN
cord-018764-02l423mk	365	51	,	,	,
cord-018764-02l423mk	365	52	potassium	potassium	NN
cord-018764-02l423mk	365	53	,	,	,
cord-018764-02l423mk	365	54	and	and	CC
cord-018764-02l423mk	365	55	adenosine	adenosine	NN
cord-018764-02l423mk	365	56	triphosphate	triphosphate	NN
cord-018764-02l423mk	365	57	contents	content	NNS
cord-018764-02l423mk	365	58	of	of	IN
cord-018764-02l423mk	365	59	red	red	JJ
cord-018764-02l423mk	365	60	blood	blood	NN
cord-018764-02l423mk	365	61	cells	cell	NNS
cord-018764-02l423mk	365	62	in	in	IN
cord-018764-02l423mk	365	63	sepsis	sepsis	NN
cord-018764-02l423mk	365	64	and	and	CC
cord-018764-02l423mk	365	65	septic	septic	JJ
cord-018764-02l423mk	365	66	shock	shock	NN
cord-018764-02l423mk	366	1	Autocrine	Autocrine	NNP
cord-018764-02l423mk	366	2	inhibition	inhibition	NN
cord-018764-02l423mk	366	3	of	of	IN
cord-018764-02l423mk	366	4	Na	Na	NNP
cord-018764-02l423mk	366	5	+	+	CC
cord-018764-02l423mk	366	6	/K	/K	.
cord-018764-02l423mk	367	1	+	+	CC
cord-018764-02l423mk	368	1	-ATPase	-atpase	IN
cord-018764-02l423mk	368	2	by	by	IN
cord-018764-02l423mk	368	3	nitric	nitric	JJ
cord-018764-02l423mk	368	4	oxide	oxide	NN
cord-018764-02l423mk	368	5	in	in	IN
cord-018764-02l423mk	368	6	mouse	mouse	NN
cord-018764-02l423mk	368	7	proximal	proximal	JJ
cord-018764-02l423mk	368	8	tubule	tubule	NN
cord-018764-02l423mk	368	9	epithelial	epithelial	JJ
cord-018764-02l423mk	368	10	cells	cell	NNS
cord-018764-02l423mk	369	1	Erythrocyte	Erythrocyte	NNP
cord-018764-02l423mk	369	2	deformability	deformability	NN
cord-018764-02l423mk	369	3	is	be	VBZ
cord-018764-02l423mk	369	4	a	a	DT
cord-018764-02l423mk	369	5	nitric	nitric	JJ
cord-018764-02l423mk	369	6	oxide	oxide	NN
cord-018764-02l423mk	369	7	-	-	HYPH
cord-018764-02l423mk	369	8	mediated	mediate	VBN
cord-018764-02l423mk	369	9	factor	factor	NN
cord-018764-02l423mk	369	10	in	in	IN
cord-018764-02l423mk	369	11	decreased	decrease	VBD
cord-018764-02l423mk	369	12	capillary	capillary	JJ
cord-018764-02l423mk	369	13	density	density	NN
cord-018764-02l423mk	369	14	during	during	IN
cord-018764-02l423mk	369	15	sepsis	sepsis	NN
cord-018764-02l423mk	369	16	Sodium	sodium	NN
cord-018764-02l423mk	369	17	transport	transport	NN
cord-018764-02l423mk	369	18	and	and	CC
cord-018764-02l423mk	369	19	red	red	JJ
cord-018764-02l423mk	369	20	cell	cell	NN
cord-018764-02l423mk	369	21	deformability	deformability	NN
cord-018764-02l423mk	369	22	Red	red	JJ
cord-018764-02l423mk	369	23	blood	blood	NN
cord-018764-02l423mk	369	24	cell	cell	NN
cord-018764-02l423mk	369	25	physiology	physiology	NN
cord-018764-02l423mk	369	26	in	in	IN
cord-018764-02l423mk	369	27	critical	critical	JJ
cord-018764-02l423mk	369	28	illness	illness	NN
cord-018764-02l423mk	370	1	Diminished	diminish	VBN
cord-018764-02l423mk	370	2	red	red	JJ
cord-018764-02l423mk	370	3	blood	blood	NN
cord-018764-02l423mk	370	4	cell	cell	NN
cord-018764-02l423mk	370	5	deformability	deformability	NN
cord-018764-02l423mk	370	6	in	in	IN
cord-018764-02l423mk	370	7	uncomplicated	uncomplicated	JJ
cord-018764-02l423mk	370	8	human	human	JJ
cord-018764-02l423mk	370	9	malaria	malaria	NN
cord-018764-02l423mk	370	10	.	.	.
cord-018764-02l423mk	371	1	A	a	DT
cord-018764-02l423mk	371	2	preliminary	preliminary	JJ
cord-018764-02l423mk	371	3	report	report	NN
cord-018764-02l423mk	371	4	Alterations	alteration	NNS
cord-018764-02l423mk	371	5	of	of	IN
cord-018764-02l423mk	371	6	capillary	capillary	JJ
cord-018764-02l423mk	371	7	flow	flow	NN
cord-018764-02l423mk	371	8	during	during	IN
cord-018764-02l423mk	371	9	sepsis	sepsis	NN
cord-018764-02l423mk	371	10	Red	red	JJ
cord-018764-02l423mk	371	11	blood	blood	NN
cord-018764-02l423mk	371	12	cell	cell	NN
cord-018764-02l423mk	371	13	deformability	deformability	NN
cord-018764-02l423mk	371	14	in	in	IN
cord-018764-02l423mk	371	15	human	human	JJ
cord-018764-02l423mk	371	16	and	and	CC
cord-018764-02l423mk	371	17	experimental	experimental	JJ
cord-018764-02l423mk	371	18	sepsis	sepsis	NN
cord-018764-02l423mk	371	19	Prognostic	prognostic	JJ
cord-018764-02l423mk	371	20	significance	significance	NN
cord-018764-02l423mk	371	21	of	of	IN
cord-018764-02l423mk	371	22	reduced	reduce	VBN
cord-018764-02l423mk	371	23	red	red	JJ
cord-018764-02l423mk	371	24	blood	blood	NN
cord-018764-02l423mk	371	25	cell	cell	NN
cord-018764-02l423mk	371	26	deformability	deformability	NN
cord-018764-02l423mk	371	27	in	in	IN
cord-018764-02l423mk	371	28	severe	severe	JJ
cord-018764-02l423mk	371	29	falciparum	falciparum	NN
cord-018764-02l423mk	371	30	malaria	malaria	NN
cord-018764-02l423mk	371	31	Red	red	JJ
cord-018764-02l423mk	371	32	blood	blood	NN
cord-018764-02l423mk	371	33	cell	cell	NN
cord-018764-02l423mk	371	34	deformability	deformability	NN
cord-018764-02l423mk	371	35	as	as	IN
cord-018764-02l423mk	371	36	a	a	DT
cord-018764-02l423mk	371	37	predictor	predictor	NN
cord-018764-02l423mk	371	38	of	of	IN
cord-018764-02l423mk	371	39	anemia	anemia	NN
cord-018764-02l423mk	371	40	in	in	IN
cord-018764-02l423mk	371	41	severe	severe	JJ
cord-018764-02l423mk	371	42	falciparum	falciparum	NN
cord-018764-02l423mk	371	43	malaria	malaria	NN
cord-018764-02l423mk	371	44	Bone	Bone	NNP
cord-018764-02l423mk	371	45	marrow	marrow	NN
cord-018764-02l423mk	371	46	changes	change	NNS
cord-018764-02l423mk	371	47	in	in	IN
cord-018764-02l423mk	371	48	human	human	JJ
cord-018764-02l423mk	371	49	malaria	malaria	NN
cord-018764-02l423mk	371	50	Ineffective	ineffective	JJ
cord-018764-02l423mk	371	51	erythropoiesis	erythropoiesis	NN
cord-018764-02l423mk	371	52	in	in	IN
cord-018764-02l423mk	371	53	acute	acute	JJ
cord-018764-02l423mk	371	54	human	human	JJ
cord-018764-02l423mk	371	55	P.	P.	NNP
cord-018764-02l423mk	371	56	falciparum	falciparum	NN
cord-018764-02l423mk	371	57	malaria	malaria	NN
cord-018764-02l423mk	372	1	The	the	DT
cord-018764-02l423mk	372	2	bone	bone	NN
cord-018764-02l423mk	372	3	marrow	marrow	NN
cord-018764-02l423mk	372	4	in	in	IN
cord-018764-02l423mk	372	5	human	human	JJ
cord-018764-02l423mk	372	6	cerebral	cerebral	JJ
cord-018764-02l423mk	372	7	malaria	malaria	NN
cord-018764-02l423mk	372	8	:	:	:
cord-018764-02l423mk	372	9	parasite	parasite	NN
cord-018764-02l423mk	372	10	sequestration	sequestration	NN
cord-018764-02l423mk	372	11	within	within	IN
cord-018764-02l423mk	372	12	sinusoids	sinusoid	NNS
cord-018764-02l423mk	372	13	Dyserythropoiesis	Dyserythropoiesis	NNP
cord-018764-02l423mk	372	14	and	and	CC
cord-018764-02l423mk	372	15	ineffective	ineffective	JJ
cord-018764-02l423mk	372	16	erythropoiesis	erythropoiesis	NN
cord-018764-02l423mk	372	17	in	in	IN
cord-018764-02l423mk	372	18	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	372	19	vivax	vivax	NN
cord-018764-02l423mk	372	20	malaria	malaria	NN
cord-018764-02l423mk	372	21	Inhibiton	Inhibiton	NNP
cord-018764-02l423mk	372	22	of	of	IN
cord-018764-02l423mk	372	23	the	the	DT
cord-018764-02l423mk	372	24	growth	growth	NN
cord-018764-02l423mk	372	25	and	and	CC
cord-018764-02l423mk	372	26	differentiation	differentiation	NN
cord-018764-02l423mk	372	27	of	of	IN
cord-018764-02l423mk	372	28	erythroid	erythroid	NN
cord-018764-02l423mk	372	29	precursor	precursor	NN
cord-018764-02l423mk	372	30	cells	cell	NNS
cord-018764-02l423mk	372	31	by	by	IN
cord-018764-02l423mk	372	32	an	an	DT
cord-018764-02l423mk	372	33	endotoxin	endotoxin	NN
cord-018764-02l423mk	372	34	-	-	HYPH
cord-018764-02l423mk	372	35	induced	induce	VBN
cord-018764-02l423mk	372	36	mediator	mediator	NN
cord-018764-02l423mk	372	37	from	from	IN
cord-018764-02l423mk	372	38	peritoneal	peritoneal	JJ
cord-018764-02l423mk	372	39	macrophages	macrophage	NNS
cord-018764-02l423mk	372	40	Identity	identity	NN
cord-018764-02l423mk	372	41	of	of	IN
cord-018764-02l423mk	372	42	tumour	tumour	NN
cord-018764-02l423mk	372	43	necrosis	necrosis	NN
cord-018764-02l423mk	372	44	factor	factor	NN
cord-018764-02l423mk	373	1	and	and	CC
cord-018764-02l423mk	373	2	the	the	DT
cord-018764-02l423mk	373	3	macrophagesecreted	macrophagesecrete	VBN
cord-018764-02l423mk	373	4	factor	factor	NN
cord-018764-02l423mk	374	1	cachectin	cachectin	NNP
cord-018764-02l423mk	374	2	Tumour	tumour	NN
cord-018764-02l423mk	374	3	necrosis	necrosis	NN
cord-018764-02l423mk	374	4	factor	factor	NN
cord-018764-02l423mk	374	5	may	may	MD
cord-018764-02l423mk	374	6	contribute	contribute	VB
cord-018764-02l423mk	374	7	to	to	IN
cord-018764-02l423mk	374	8	the	the	DT
cord-018764-02l423mk	374	9	anaemia	anaemia	NN
cord-018764-02l423mk	374	10	of	of	IN
cord-018764-02l423mk	374	11	malaria	malaria	NN
cord-018764-02l423mk	374	12	by	by	IN
cord-018764-02l423mk	374	13	causing	cause	VBG
cord-018764-02l423mk	374	14	dyserythropoiesis	dyserythropoiesis	NN
cord-018764-02l423mk	374	15	and	and	CC
cord-018764-02l423mk	374	16	erythrophagocytosis	erythrophagocytosis	NNP
cord-018764-02l423mk	375	1	A	a	DT
cord-018764-02l423mk	375	2	low	low	JJ
cord-018764-02l423mk	375	3	interleukin-10	interleukin-10	NN
cord-018764-02l423mk	375	4	tumor	tumor	NN
cord-018764-02l423mk	375	5	necrosis	necrosis	NN
cord-018764-02l423mk	375	6	factor	factor	NN
cord-018764-02l423mk	375	7	-	-	HYPH
cord-018764-02l423mk	375	8	alpha	alpha	NN
cord-018764-02l423mk	375	9	ratio	ratio	NN
cord-018764-02l423mk	375	10	is	be	VBZ
cord-018764-02l423mk	375	11	associated	associate	VBN
cord-018764-02l423mk	375	12	with	with	IN
cord-018764-02l423mk	375	13	malaria	malaria	NN
cord-018764-02l423mk	375	14	anemia	anemia	NN
cord-018764-02l423mk	375	15	in	in	IN
cord-018764-02l423mk	375	16	children	child	NNS
cord-018764-02l423mk	375	17	residing	reside	VBG
cord-018764-02l423mk	375	18	in	in	IN
cord-018764-02l423mk	375	19	a	a	DT
cord-018764-02l423mk	375	20	holoendemic	holoendemic	JJ
cord-018764-02l423mk	375	21	malaria	malaria	NN
cord-018764-02l423mk	375	22	region	region	NN
cord-018764-02l423mk	375	23	in	in	IN
cord-018764-02l423mk	375	24	western	western	JJ
cord-018764-02l423mk	375	25	Kenya	Kenya	NNP
cord-018764-02l423mk	375	26	Reduced	Reduced	NNP
cord-018764-02l423mk	375	27	interleukin-12	interleukin-12	NNP
cord-018764-02l423mk	375	28	and	and	CC
cord-018764-02l423mk	375	29	transforming	transform	VBG
cord-018764-02l423mk	375	30	growth	growth	NN
cord-018764-02l423mk	375	31	factor	factor	NN
cord-018764-02l423mk	375	32	-	-	HYPH
cord-018764-02l423mk	375	33	beta1	beta1	NN
cord-018764-02l423mk	375	34	in	in	IN
cord-018764-02l423mk	375	35	severe	severe	JJ
cord-018764-02l423mk	375	36	childhood	childhood	NN
cord-018764-02l423mk	375	37	malaria	malaria	NN
cord-018764-02l423mk	375	38	:	:	:
cord-018764-02l423mk	375	39	relationship	relationship	NN
cord-018764-02l423mk	375	40	of	of	IN
cord-018764-02l423mk	375	41	cytokine	cytokine	NN
cord-018764-02l423mk	375	42	balance	balance	NN
cord-018764-02l423mk	375	43	with	with	IN
cord-018764-02l423mk	375	44	disease	disease	NN
cord-018764-02l423mk	375	45	severity	severity	NN
cord-018764-02l423mk	375	46	Plasma	plasma	NN
cord-018764-02l423mk	375	47	interleukin-10	interleukin-10	NN
cord-018764-02l423mk	375	48	:	:	:
cord-018764-02l423mk	375	49	tumor	tumor	NN
cord-018764-02l423mk	375	50	necrosis	necrosis	NN
cord-018764-02l423mk	375	51	factor	factor	NN
cord-018764-02l423mk	375	52	(	(	-LRB-
cord-018764-02l423mk	375	53	TNF)-alpha	tnf)-alpha	CD
cord-018764-02l423mk	375	54	ratio	ratio	NN
cord-018764-02l423mk	375	55	is	be	VBZ
cord-018764-02l423mk	375	56	associated	associate	VBN
cord-018764-02l423mk	375	57	with	with	IN
cord-018764-02l423mk	375	58	TNF	tnf	NN
cord-018764-02l423mk	375	59	promoter	promoter	NN
cord-018764-02l423mk	375	60	variants	variant	NNS
cord-018764-02l423mk	375	61	and	and	CC
cord-018764-02l423mk	375	62	predicts	predict	VBZ
cord-018764-02l423mk	375	63	malarial	malarial	JJ
cord-018764-02l423mk	375	64	complications	complication	NNS
cord-018764-02l423mk	375	65	Absolute	absolute	JJ
cord-018764-02l423mk	375	66	levels	level	NNS
cord-018764-02l423mk	375	67	and	and	CC
cord-018764-02l423mk	375	68	ratios	ratio	NNS
cord-018764-02l423mk	375	69	of	of	IN
cord-018764-02l423mk	375	70	proinflammatory	proinflammatory	JJ
cord-018764-02l423mk	375	71	and	and	CC
cord-018764-02l423mk	375	72	anti	anti	JJ
cord-018764-02l423mk	375	73	-	-	JJ
cord-018764-02l423mk	375	74	inflammatory	inflammatory	JJ
cord-018764-02l423mk	375	75	cytokine	cytokine	NN
cord-018764-02l423mk	375	76	production	production	NN
cord-018764-02l423mk	375	77	in	in	IN
cord-018764-02l423mk	375	78	vitro	vitro	FW
cord-018764-02l423mk	375	79	predict	predict	VBP
cord-018764-02l423mk	375	80	clinical	clinical	JJ
cord-018764-02l423mk	375	81	immunity	immunity	NN
cord-018764-02l423mk	375	82	to	to	IN
cord-018764-02l423mk	375	83	Plasmodium	plasmodium	NN
cord-018764-02l423mk	375	84	falciparum	falciparum	NN
cord-018764-02l423mk	375	85	malaria	malaria	NN
cord-018764-02l423mk	375	86	Low	low	JJ
cord-018764-02l423mk	375	87	interleukin-12	interleukin-12	CD
cord-018764-02l423mk	375	88	activity	activity	NN
cord-018764-02l423mk	375	89	in	in	IN
cord-018764-02l423mk	375	90	severe	severe	JJ
cord-018764-02l423mk	375	91	Plasmodium	plasmodium	NN
cord-018764-02l423mk	375	92	falciparum	falciparum	NN
cord-018764-02l423mk	375	93	malaria	malaria	NN
cord-018764-02l423mk	375	94	Severe	severe	JJ
cord-018764-02l423mk	375	95	malarial	malarial	JJ
cord-018764-02l423mk	375	96	anemia	anemia	NN
cord-018764-02l423mk	375	97	associated	associate	VBN
cord-018764-02l423mk	375	98	with	with	IN
cord-018764-02l423mk	375	99	increased	increase	VBN
cord-018764-02l423mk	375	100	soluble	soluble	JJ
cord-018764-02l423mk	375	101	Fas	Fas	NNP
cord-018764-02l423mk	375	102	ligand	ligand	NN
cord-018764-02l423mk	375	103	(	(	-LRB-
cord-018764-02l423mk	375	104	sFasL	sFasL	NNP
cord-018764-02l423mk	375	105	)	)	-RRB-
cord-018764-02l423mk	375	106	concentrations	concentration	NNS
cord-018764-02l423mk	375	107	in	in	IN
cord-018764-02l423mk	375	108	Gabonese	gabonese	JJ
cord-018764-02l423mk	375	109	children	child	NNS
cord-018764-02l423mk	375	110	Bone	Bone	NNP
cord-018764-02l423mk	375	111	marrow	marrow	NN
cord-018764-02l423mk	375	112	suppression	suppression	NN
cord-018764-02l423mk	375	113	and	and	CC
cord-018764-02l423mk	375	114	severe	severe	JJ
cord-018764-02l423mk	375	115	anaemia	anaemia	NN
cord-018764-02l423mk	375	116	associated	associate	VBN
cord-018764-02l423mk	375	117	with	with	IN
cord-018764-02l423mk	375	118	persistent	persistent	JJ
cord-018764-02l423mk	375	119	Plasmodium	plasmodium	NN
cord-018764-02l423mk	375	120	falciparum	falciparum	NN
cord-018764-02l423mk	375	121	infection	infection	NN
cord-018764-02l423mk	375	122	in	in	IN
cord-018764-02l423mk	375	123	African	african	JJ
cord-018764-02l423mk	375	124	children	child	NNS
cord-018764-02l423mk	375	125	with	with	IN
cord-018764-02l423mk	375	126	microscopically	microscopically	RB
cord-018764-02l423mk	375	127	undetectable	undetectable	JJ
cord-018764-02l423mk	375	128	parasitaemia	parasitaemia	NNP
cord-018764-02l423mk	375	129	Macrophage	Macrophage	NNP
cord-018764-02l423mk	375	130	migration	migration	NN
cord-018764-02l423mk	375	131	inhibitory	inhibitory	JJ
cord-018764-02l423mk	375	132	factor	factor	NN
cord-018764-02l423mk	375	133	release	release	NN
cord-018764-02l423mk	375	134	by	by	IN
cord-018764-02l423mk	375	135	macrophages	macrophage	NNS
cord-018764-02l423mk	375	136	after	after	IN
cord-018764-02l423mk	375	137	ingestion	ingestion	NN
cord-018764-02l423mk	375	138	of	of	IN
cord-018764-02l423mk	375	139	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	375	140	chabaudi	chabaudi	NNP
cord-018764-02l423mk	375	141	-	-	HYPH
cord-018764-02l423mk	375	142	infected	infect	VBN
cord-018764-02l423mk	375	143	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	375	144	:	:	:
cord-018764-02l423mk	376	1	Possible	possible	JJ
cord-018764-02l423mk	376	2	role	role	NN
cord-018764-02l423mk	376	3	in	in	IN
cord-018764-02l423mk	376	4	the	the	DT
cord-018764-02l423mk	376	5	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	376	6	of	of	IN
cord-018764-02l423mk	376	7	malarial	malarial	JJ
cord-018764-02l423mk	376	8	anemia	anemia	NN
cord-018764-02l423mk	376	9	A	a	DT
cord-018764-02l423mk	376	10	critical	critical	JJ
cord-018764-02l423mk	376	11	role	role	NN
cord-018764-02l423mk	376	12	for	for	IN
cord-018764-02l423mk	376	13	the	the	DT
cord-018764-02l423mk	376	14	host	host	NN
cord-018764-02l423mk	376	15	mediator	mediator	NN
cord-018764-02l423mk	376	16	macrophage	macrophage	NN
cord-018764-02l423mk	376	17	migration	migration	NN
cord-018764-02l423mk	376	18	inhibitory	inhibitory	JJ
cord-018764-02l423mk	376	19	factor	factor	NN
cord-018764-02l423mk	376	20	in	in	IN
cord-018764-02l423mk	376	21	the	the	DT
cord-018764-02l423mk	376	22	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	376	23	of	of	IN
cord-018764-02l423mk	376	24	malarial	malarial	JJ
cord-018764-02l423mk	376	25	anemia	anemia	NN
cord-018764-02l423mk	376	26	Cytopathic	cytopathic	JJ
cord-018764-02l423mk	376	27	hypoxia	hypoxia	NN
cord-018764-02l423mk	376	28	.	.	.
cord-018764-02l423mk	377	1	Mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	377	2	dysfunction	dysfunction	NN
cord-018764-02l423mk	377	3	as	as	IN
cord-018764-02l423mk	377	4	mechanism	mechanism	NN
cord-018764-02l423mk	377	5	contributing	contribute	VBG
cord-018764-02l423mk	377	6	to	to	IN
cord-018764-02l423mk	377	7	organ	organ	NN
cord-018764-02l423mk	377	8	dysfunction	dysfunction	NN
cord-018764-02l423mk	377	9	in	in	IN
cord-018764-02l423mk	377	10	sepsis	sepsis	NN
cord-018764-02l423mk	377	11	Evaluation	Evaluation	NNP
cord-018764-02l423mk	377	12	of	of	IN
cord-018764-02l423mk	377	13	the	the	DT
cord-018764-02l423mk	377	14	role	role	NN
cord-018764-02l423mk	377	15	of	of	IN
cord-018764-02l423mk	377	16	cellular	cellular	JJ
cord-018764-02l423mk	377	17	hypoxia	hypoxia	NN
cord-018764-02l423mk	377	18	in	in	IN
cord-018764-02l423mk	377	19	sepsis	sepsis	NN
cord-018764-02l423mk	377	20	by	by	IN
cord-018764-02l423mk	378	1	the	the	DT
cord-018764-02l423mk	378	2	hypoxic	hypoxic	JJ
cord-018764-02l423mk	378	3	marker	marker	NN
cord-018764-02l423mk	378	4	[	[	-LRB-
cord-018764-02l423mk	378	5	18	18	CD
cord-018764-02l423mk	378	6	F]fluoromisonidazole	F]fluoromisonidazole	NNP
cord-018764-02l423mk	378	7	Skeletal	skeletal	JJ
cord-018764-02l423mk	378	8	muscle	muscle	NN
cord-018764-02l423mk	378	9	partial	partial	JJ
cord-018764-02l423mk	378	10	pressure	pressure	NN
cord-018764-02l423mk	378	11	of	of	IN
cord-018764-02l423mk	378	12	oxygen	oxygen	NN
cord-018764-02l423mk	378	13	in	in	IN
cord-018764-02l423mk	378	14	patients	patient	NNS
cord-018764-02l423mk	378	15	with	with	IN
cord-018764-02l423mk	378	16	sepsis	sepsis	NN
cord-018764-02l423mk	378	17	Cytopathic	cytopathic	JJ
cord-018764-02l423mk	378	18	hypoxia	hypoxia	NN
cord-018764-02l423mk	378	19	in	in	IN
cord-018764-02l423mk	378	20	sepsis	sepsis	NN
cord-018764-02l423mk	379	1	A	a	DT
cord-018764-02l423mk	379	2	global	global	JJ
cord-018764-02l423mk	379	3	approach	approach	NN
cord-018764-02l423mk	379	4	to	to	IN
cord-018764-02l423mk	379	5	energy	energy	NN
cord-018764-02l423mk	379	6	metabolism	metabolism	NN
cord-018764-02l423mk	379	7	in	in	IN
cord-018764-02l423mk	379	8	an	an	DT
cord-018764-02l423mk	379	9	experimental	experimental	JJ
cord-018764-02l423mk	379	10	model	model	NN
cord-018764-02l423mk	379	11	of	of	IN
cord-018764-02l423mk	379	12	sepsis	sepsis	NN
cord-018764-02l423mk	379	13	Mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	379	14	dysfunction	dysfunction	NN
cord-018764-02l423mk	379	15	in	in	IN
cord-018764-02l423mk	379	16	a	a	DT
cord-018764-02l423mk	379	17	long	long	JJ
cord-018764-02l423mk	379	18	-	-	HYPH
cord-018764-02l423mk	379	19	term	term	NN
cord-018764-02l423mk	379	20	rodent	rodent	NN
cord-018764-02l423mk	379	21	model	model	NN
cord-018764-02l423mk	379	22	of	of	IN
cord-018764-02l423mk	379	23	sepsis	sepsis	NN
cord-018764-02l423mk	379	24	and	and	CC
cord-018764-02l423mk	379	25	organ	organ	NN
cord-018764-02l423mk	379	26	failure	failure	NN
cord-018764-02l423mk	379	27	Association	Association	NNP
cord-018764-02l423mk	379	28	between	between	IN
cord-018764-02l423mk	379	29	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	379	30	dysfunction	dysfunction	NN
cord-018764-02l423mk	379	31	and	and	CC
cord-018764-02l423mk	379	32	severity	severity	NN
cord-018764-02l423mk	379	33	and	and	CC
cord-018764-02l423mk	379	34	outcome	outcome	NN
cord-018764-02l423mk	379	35	of	of	IN
cord-018764-02l423mk	379	36	septic	septic	JJ
cord-018764-02l423mk	379	37	shock	shock	NN
cord-018764-02l423mk	379	38	Mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	379	39	dysfunction	dysfunction	NN
cord-018764-02l423mk	379	40	in	in	IN
cord-018764-02l423mk	379	41	patients	patient	NNS
cord-018764-02l423mk	379	42	with	with	IN
cord-018764-02l423mk	379	43	severe	severe	JJ
cord-018764-02l423mk	379	44	sepsis	sepsis	NN
cord-018764-02l423mk	379	45	:	:	:
cord-018764-02l423mk	379	46	An	an	DT
cord-018764-02l423mk	379	47	EPR	EPR	NNP
cord-018764-02l423mk	379	48	interrogation	interrogation	NN
cord-018764-02l423mk	379	49	of	of	IN
cord-018764-02l423mk	379	50	individual	individual	JJ
cord-018764-02l423mk	379	51	respiratory	respiratory	JJ
cord-018764-02l423mk	379	52	chain	chain	NN
cord-018764-02l423mk	379	53	components	component	NNS
cord-018764-02l423mk	379	54	Elevated	elevated	JJ
cord-018764-02l423mk	379	55	tumour	tumour	NN
cord-018764-02l423mk	379	56	necrosis	necrosis	NN
cord-018764-02l423mk	379	57	factor	factor	NN
cord-018764-02l423mk	379	58	alpha	alpha	NN
cord-018764-02l423mk	379	59	and	and	CC
cord-018764-02l423mk	379	60	interleukin-6	interleukin-6	NNP
cord-018764-02l423mk	379	61	serum	serum	NN
cord-018764-02l423mk	379	62	levels	level	NNS
cord-018764-02l423mk	379	63	as	as	IN
cord-018764-02l423mk	379	64	markers	marker	NNS
cord-018764-02l423mk	379	65	for	for	IN
cord-018764-02l423mk	379	66	complicated	complicated	JJ
cord-018764-02l423mk	379	67	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	379	68	falciparum	falciparum	NN
cord-018764-02l423mk	379	69	malaria	malaria	NN
cord-018764-02l423mk	379	70	TNF	TNF	NNP
cord-018764-02l423mk	379	71	concentration	concentration	NN
cord-018764-02l423mk	379	72	in	in	IN
cord-018764-02l423mk	379	73	fatal	fatal	JJ
cord-018764-02l423mk	379	74	cerebral	cerebral	JJ
cord-018764-02l423mk	379	75	,	,	,
cord-018764-02l423mk	379	76	non	non	JJ
cord-018764-02l423mk	379	77	-	-	JJ
cord-018764-02l423mk	379	78	fatal	fatal	JJ
cord-018764-02l423mk	379	79	cerebral	cerebral	JJ
cord-018764-02l423mk	379	80	,	,	,
cord-018764-02l423mk	379	81	and	and	CC
cord-018764-02l423mk	379	82	uncomplicated	uncomplicated	JJ
cord-018764-02l423mk	379	83	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	379	84	falciparum	falciparum	NN
cord-018764-02l423mk	379	85	malaria	malaria	NN
cord-018764-02l423mk	379	86	Mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	379	87	dysfunction	dysfunction	NN
cord-018764-02l423mk	379	88	and	and	CC
cord-018764-02l423mk	379	89	glutamate	glutamate	NN
cord-018764-02l423mk	379	90	excitotoxicity	excitotoxicity	NN
cord-018764-02l423mk	379	91	studied	study	VBN
cord-018764-02l423mk	379	92	in	in	IN
cord-018764-02l423mk	379	93	primary	primary	JJ
cord-018764-02l423mk	379	94	neuronal	neuronal	JJ
cord-018764-02l423mk	379	95	cultures	culture	NNS
cord-018764-02l423mk	379	96	A	a	DT
cord-018764-02l423mk	379	97	factor	factor	NN
cord-018764-02l423mk	379	98	in	in	IN
cord-018764-02l423mk	379	99	the	the	DT
cord-018764-02l423mk	379	100	serum	serum	NN
cord-018764-02l423mk	379	101	of	of	IN
cord-018764-02l423mk	379	102	malaria	malaria	NN
cord-018764-02l423mk	379	103	-	-	HYPH
cord-018764-02l423mk	379	104	infected	infect	VBN
cord-018764-02l423mk	379	105	animals	animal	NNS
cord-018764-02l423mk	379	106	capable	capable	JJ
cord-018764-02l423mk	379	107	of	of	IN
cord-018764-02l423mk	379	108	inhibiting	inhibit	VBG
cord-018764-02l423mk	379	109	the	the	DT
cord-018764-02l423mk	379	110	in	in	FW
cord-018764-02l423mk	379	111	vitro	vitro	FW
cord-018764-02l423mk	379	112	oxidative	oxidative	JJ
cord-018764-02l423mk	379	113	metabolism	metabolism	NN
cord-018764-02l423mk	379	114	of	of	IN
cord-018764-02l423mk	379	115	normal	normal	JJ
cord-018764-02l423mk	379	116	liver	liver	NN
cord-018764-02l423mk	379	117	mitochondria	mitochondrion	NNS
cord-018764-02l423mk	380	1	The	the	DT
cord-018764-02l423mk	380	2	inhibition	inhibition	NN
cord-018764-02l423mk	380	3	of	of	IN
cord-018764-02l423mk	380	4	mitochondrial	mitochondrial	JJ
cord-018764-02l423mk	380	5	respiration	respiration	NN
cord-018764-02l423mk	380	6	and	and	CC
cord-018764-02l423mk	380	7	oxidative	oxidative	JJ
cord-018764-02l423mk	380	8	phosphorylation	phosphorylation	NN
cord-018764-02l423mk	380	9	by	by	IN
cord-018764-02l423mk	380	10	serum	serum	NN
cord-018764-02l423mk	380	11	from	from	IN
cord-018764-02l423mk	380	12	malaria	malaria	NN
cord-018764-02l423mk	380	13	-	-	HYPH
cord-018764-02l423mk	380	14	infected	infect	VBN
cord-018764-02l423mk	380	15	animals	animal	NNS
cord-018764-02l423mk	380	16	.	.	.
cord-018764-02l423mk	381	1	II	II	NNP
cord-018764-02l423mk	381	2	.	.	.
cord-018764-02l423mk	382	1	The	the	DT
cord-018764-02l423mk	382	2	inhibitory	inhibitory	JJ
cord-018764-02l423mk	382	3	activity	activity	NN
cord-018764-02l423mk	382	4	of	of	IN
cord-018764-02l423mk	382	5	serum	serum	NN
cord-018764-02l423mk	382	6	ultrafitrates	ultrafitrate	NNS
cord-018764-02l423mk	382	7	from	from	IN
cord-018764-02l423mk	382	8	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	382	9	knowlesi	knowlesi	RB
cord-018764-02l423mk	382	10	-	-	HYPH
cord-018764-02l423mk	382	11	infected	infect	VBN
cord-018764-02l423mk	382	12	monkeys	monkey	NNS
cord-018764-02l423mk	383	1	The	the	DT
cord-018764-02l423mk	383	2	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	383	3	of	of	IN
cord-018764-02l423mk	383	4	mammalian	mammalian	JJ
cord-018764-02l423mk	383	5	malaria	malaria	NN
cord-018764-02l423mk	383	6	Acid	acid	NN
cord-018764-02l423mk	383	7	-	-	HYPH
cord-018764-02l423mk	383	8	base	base	NN
cord-018764-02l423mk	383	9	status	status	NN
cord-018764-02l423mk	383	10	in	in	IN
cord-018764-02l423mk	383	11	paediatric	paediatric	JJ
cord-018764-02l423mk	383	12	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	383	13	falciparum	falciparum	NN
cord-018764-02l423mk	383	14	malaria	malaria	NN
cord-018764-02l423mk	383	15	Lactic	lactic	JJ
cord-018764-02l423mk	383	16	acidosis	acidosis	NN
cord-018764-02l423mk	383	17	and	and	CC
cord-018764-02l423mk	383	18	hypoglycaemia	hypoglycaemia	NN
cord-018764-02l423mk	383	19	in	in	IN
cord-018764-02l423mk	383	20	children	child	NNS
cord-018764-02l423mk	383	21	with	with	IN
cord-018764-02l423mk	383	22	severe	severe	JJ
cord-018764-02l423mk	383	23	malaria	malaria	NN
cord-018764-02l423mk	383	24	-pathophysiological	-pathophysiological	JJ
cord-018764-02l423mk	383	25	and	and	CC
cord-018764-02l423mk	383	26	prognostic	prognostic	JJ
cord-018764-02l423mk	383	27	significance	significance	NN
cord-018764-02l423mk	384	1	The	the	DT
cord-018764-02l423mk	384	2	significance	significance	NN
cord-018764-02l423mk	384	3	of	of	IN
cord-018764-02l423mk	384	4	type	type	NN
cord-018764-02l423mk	384	5	B	b	NN
cord-018764-02l423mk	384	6	hyperlactataemia	hyperlactataemia	NN
cord-018764-02l423mk	384	7	in	in	IN
cord-018764-02l423mk	384	8	infective	infective	JJ
cord-018764-02l423mk	384	9	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	384	10	Characterisation	Characterisation	NNP
cord-018764-02l423mk	384	11	of	of	IN
cord-018764-02l423mk	384	12	metabolic	metabolic	JJ
cord-018764-02l423mk	384	13	acidosis	acidosis	NN
cord-018764-02l423mk	384	14	in	in	IN
cord-018764-02l423mk	384	15	Kenyan	kenyan	JJ
cord-018764-02l423mk	384	16	children	child	NNS
cord-018764-02l423mk	384	17	admitted	admit	VBN
cord-018764-02l423mk	384	18	to	to	IN
cord-018764-02l423mk	384	19	hospital	hospital	NN
cord-018764-02l423mk	384	20	for	for	IN
cord-018764-02l423mk	384	21	acute	acute	JJ
cord-018764-02l423mk	384	22	non	non	JJ
cord-018764-02l423mk	384	23	-	-	JJ
cord-018764-02l423mk	384	24	surgical	surgical	JJ
cord-018764-02l423mk	384	25	conditions	condition	NNS
cord-018764-02l423mk	385	1	Protons	proton	NNS
cord-018764-02l423mk	385	2	in	in	IN
cord-018764-02l423mk	385	3	ischemia	ischemia	NN
cord-018764-02l423mk	385	4	:	:	:
cord-018764-02l423mk	386	1	where	where	WRB
cord-018764-02l423mk	386	2	do	do	VBP
cord-018764-02l423mk	386	3	they	-PRON-	PRP
cord-018764-02l423mk	386	4	come	come	VB
cord-018764-02l423mk	386	5	from	from	IN
cord-018764-02l423mk	386	6	;	;	:
cord-018764-02l423mk	386	7	where	where	WRB
cord-018764-02l423mk	386	8	do	do	VBP
cord-018764-02l423mk	386	9	they	-PRON-	PRP
cord-018764-02l423mk	386	10	go	go	VB
cord-018764-02l423mk	386	11	to	to	IN
cord-018764-02l423mk	386	12	?	?	.
cord-018764-02l423mk	387	1	Reevaluation	reevaluation	NN
cord-018764-02l423mk	387	2	of	of	IN
cord-018764-02l423mk	387	3	the	the	DT
cord-018764-02l423mk	387	4	role	role	NN
cord-018764-02l423mk	387	5	of	of	IN
cord-018764-02l423mk	387	6	cellular	cellular	JJ
cord-018764-02l423mk	387	7	hypoxia	hypoxia	NN
cord-018764-02l423mk	387	8	and	and	CC
cord-018764-02l423mk	387	9	bioenergetic	bioenergetic	JJ
cord-018764-02l423mk	387	10	failure	failure	NN
cord-018764-02l423mk	387	11	in	in	IN
cord-018764-02l423mk	387	12	sepsis	sepsis	NN
cord-018764-02l423mk	387	13	Does	do	VBZ
cord-018764-02l423mk	387	14	tissue	tissue	NN
cord-018764-02l423mk	387	15	acidosis	acidosis	NN
cord-018764-02l423mk	387	16	in	in	IN
cord-018764-02l423mk	387	17	sepsis	sepsis	NN
cord-018764-02l423mk	387	18	indicate	indicate	VBP
cord-018764-02l423mk	387	19	tissue	tissue	NN
cord-018764-02l423mk	387	20	hypoperfusion	hypoperfusion	NN
cord-018764-02l423mk	387	21	?	?	.
cord-018764-02l423mk	388	1	Association	association	NN
cord-018764-02l423mk	388	2	between	between	IN
cord-018764-02l423mk	388	3	blood	blood	NN
cord-018764-02l423mk	388	4	lactate	lactate	NN
cord-018764-02l423mk	388	5	and	and	CC
cord-018764-02l423mk	388	6	acidbase	acidbase	NN
cord-018764-02l423mk	388	7	status	status	NN
cord-018764-02l423mk	388	8	and	and	CC
cord-018764-02l423mk	388	9	mortality	mortality	NN
cord-018764-02l423mk	388	10	in	in	IN
cord-018764-02l423mk	388	11	ventilated	ventilate	VBN
cord-018764-02l423mk	388	12	babies	baby	NNS
cord-018764-02l423mk	389	1	Ultimate	ultimate	JJ
cord-018764-02l423mk	389	2	survival	survival	NN
cord-018764-02l423mk	389	3	from	from	IN
cord-018764-02l423mk	389	4	septic	septic	JJ
cord-018764-02l423mk	389	5	shock	shock	NN
cord-018764-02l423mk	389	6	Severe	severe	JJ
cord-018764-02l423mk	389	7	hypoglycemia	hypoglycemia	NN
cord-018764-02l423mk	389	8	and	and	CC
cord-018764-02l423mk	389	9	hyperinsulinemia	hyperinsulinemia	NN
cord-018764-02l423mk	389	10	in	in	IN
cord-018764-02l423mk	389	11	falciparum	falciparum	NN
cord-018764-02l423mk	390	1	malaria	malaria	NNP
cord-018764-02l423mk	390	2	Malaria	Malaria	NNP
cord-018764-02l423mk	390	3	and	and	CC
cord-018764-02l423mk	390	4	fluids	fluid	NNS
cord-018764-02l423mk	390	5	-balancing	-balancing	NN
cord-018764-02l423mk	390	6	acts	act	VBZ
cord-018764-02l423mk	390	7	Thiamine	Thiamine	NNP
cord-018764-02l423mk	390	8	deficiency	deficiency	NN
cord-018764-02l423mk	390	9	and	and	CC
cord-018764-02l423mk	390	10	malaria	malaria	NN
cord-018764-02l423mk	390	11	in	in	IN
cord-018764-02l423mk	390	12	adults	adult	NNS
cord-018764-02l423mk	390	13	from	from	IN
cord-018764-02l423mk	390	14	southeast	southeast	JJ
cord-018764-02l423mk	390	15	Asia	Asia	NNP
cord-018764-02l423mk	390	16	Lactate	Lactate	NNP
cord-018764-02l423mk	390	17	homeostasis	homeostasis	NN
cord-018764-02l423mk	390	18	and	and	CC
cord-018764-02l423mk	390	19	lactic	lactic	NN
cord-018764-02l423mk	390	20	acidosis	acidosis	NN
cord-018764-02l423mk	390	21	Lactic	lactic	JJ
cord-018764-02l423mk	390	22	acidosis	acidosis	NN
cord-018764-02l423mk	390	23	in	in	IN
cord-018764-02l423mk	390	24	sepsis	sepsis	NN
cord-018764-02l423mk	390	25	:	:	:
cord-018764-02l423mk	391	1	another	another	DT
cord-018764-02l423mk	391	2	commentary	commentary	NN
cord-018764-02l423mk	391	3	Dichloroacetate	Dichloroacetate	NNP
cord-018764-02l423mk	391	4	for	for	IN
cord-018764-02l423mk	391	5	lactic	lactic	JJ
cord-018764-02l423mk	391	6	acidosis	acidosis	NN
cord-018764-02l423mk	391	7	in	in	IN
cord-018764-02l423mk	391	8	severe	severe	JJ
cord-018764-02l423mk	391	9	malaria	malaria	NN
cord-018764-02l423mk	391	10	:	:	:
cord-018764-02l423mk	391	11	a	a	DT
cord-018764-02l423mk	391	12	pharmacokinetic	pharmacokinetic	JJ
cord-018764-02l423mk	391	13	and	and	CC
cord-018764-02l423mk	391	14	pharmacodynamic	pharmacodynamic	JJ
cord-018764-02l423mk	391	15	assessment	assessment	NN
cord-018764-02l423mk	391	16	A	A	NNP
cord-018764-02l423mk	391	17	controlled	control	VBN
cord-018764-02l423mk	391	18	clinical	clinical	JJ
cord-018764-02l423mk	391	19	trial	trial	NN
cord-018764-02l423mk	391	20	of	of	IN
cord-018764-02l423mk	391	21	dichloroacetate	dichloroacetate	NN
cord-018764-02l423mk	391	22	for	for	IN
cord-018764-02l423mk	391	23	treatment	treatment	NN
cord-018764-02l423mk	391	24	of	of	IN
cord-018764-02l423mk	391	25	lactic	lactic	JJ
cord-018764-02l423mk	391	26	acidosis	acidosis	NN
cord-018764-02l423mk	391	27	in	in	IN
cord-018764-02l423mk	391	28	adults	adult	NNS
cord-018764-02l423mk	392	1	Protection	protection	NN
cord-018764-02l423mk	392	2	by	by	IN
cord-018764-02l423mk	392	3	lactate	lactate	NN
cord-018764-02l423mk	392	4	of	of	IN
cord-018764-02l423mk	392	5	cerebral	cerebral	JJ
cord-018764-02l423mk	392	6	function	function	NN
cord-018764-02l423mk	392	7	during	during	IN
cord-018764-02l423mk	392	8	hypoglycaemia	hypoglycaemia	NN
cord-018764-02l423mk	392	9	Brain	Brain	NNP
cord-018764-02l423mk	392	10	lactate	lactate	NN
cord-018764-02l423mk	392	11	,	,	,
cord-018764-02l423mk	392	12	not	not	RB
cord-018764-02l423mk	392	13	glucose	glucose	NN
cord-018764-02l423mk	392	14	,	,	,
cord-018764-02l423mk	392	15	fuels	fuel	VBZ
cord-018764-02l423mk	392	16	the	the	DT
cord-018764-02l423mk	392	17	recovery	recovery	NN
cord-018764-02l423mk	392	18	of	of	IN
cord-018764-02l423mk	392	19	synaptic	synaptic	JJ
cord-018764-02l423mk	392	20	function	function	NN
cord-018764-02l423mk	392	21	from	from	IN
cord-018764-02l423mk	392	22	hypoxia	hypoxia	NN
cord-018764-02l423mk	392	23	upon	upon	IN
cord-018764-02l423mk	392	24	reoxygenation	reoxygenation	NN
cord-018764-02l423mk	392	25	:	:	:
cord-018764-02l423mk	393	1	an	an	DT
cord-018764-02l423mk	393	2	in	in	IN
cord-018764-02l423mk	393	3	vitro	vitro	FW
cord-018764-02l423mk	393	4	study	study	NN
cord-018764-02l423mk	394	1	The	the	DT
cord-018764-02l423mk	394	2	effect	effect	NN
cord-018764-02l423mk	394	3	of	of	IN
cord-018764-02l423mk	394	4	intravenous	intravenous	JJ
cord-018764-02l423mk	394	5	lactate	lactate	NN
cord-018764-02l423mk	394	6	on	on	IN
cord-018764-02l423mk	394	7	cerebral	cerebral	JJ
cord-018764-02l423mk	394	8	function	function	NN
cord-018764-02l423mk	394	9	during	during	IN
cord-018764-02l423mk	394	10	hypoglycaemia	hypoglycaemia	NN
cord-018764-02l423mk	394	11	Lactate	Lactate	NNP
cord-018764-02l423mk	394	12	as	as	IN
cord-018764-02l423mk	394	13	a	a	DT
cord-018764-02l423mk	394	14	pivotal	pivotal	JJ
cord-018764-02l423mk	394	15	element	element	NN
cord-018764-02l423mk	394	16	in	in	IN
cord-018764-02l423mk	394	17	neuron	neuron	NN
cord-018764-02l423mk	394	18	-	-	HYPH
cord-018764-02l423mk	394	19	glia	glia	NN
cord-018764-02l423mk	394	20	metabolic	metabolic	JJ
cord-018764-02l423mk	394	21	cooperation	cooperation	NN
cord-018764-02l423mk	394	22	Unaccounted	unaccounte	VBN
cord-018764-02l423mk	394	23	for	for	IN
cord-018764-02l423mk	394	24	anion	anion	NN
cord-018764-02l423mk	394	25	in	in	IN
cord-018764-02l423mk	394	26	metabolic	metabolic	JJ
cord-018764-02l423mk	394	27	acidosis	acidosis	NN
cord-018764-02l423mk	394	28	during	during	IN
cord-018764-02l423mk	394	29	severe	severe	JJ
cord-018764-02l423mk	394	30	sepsis	sepsis	NN
cord-018764-02l423mk	394	31	in	in	IN
cord-018764-02l423mk	394	32	humans	human	NNS
cord-018764-02l423mk	394	33	Unmeasured	unmeasured	JJ
cord-018764-02l423mk	394	34	anions	anion	NNS
cord-018764-02l423mk	394	35	identified	identify	VBN
cord-018764-02l423mk	394	36	by	by	IN
cord-018764-02l423mk	394	37	the	the	DT
cord-018764-02l423mk	394	38	Fencl	Fencl	NNP
cord-018764-02l423mk	394	39	-	-	HYPH
cord-018764-02l423mk	394	40	Stewart	Stewart	NNP
cord-018764-02l423mk	394	41	method	method	NN
cord-018764-02l423mk	394	42	predict	predict	VBP
cord-018764-02l423mk	394	43	mortality	mortality	NN
cord-018764-02l423mk	394	44	better	well	RBR
cord-018764-02l423mk	394	45	than	than	IN
cord-018764-02l423mk	394	46	base	base	NN
cord-018764-02l423mk	394	47	excess	excess	NN
cord-018764-02l423mk	394	48	,	,	,
cord-018764-02l423mk	394	49	anion	anion	NN
cord-018764-02l423mk	394	50	gap	gap	NN
cord-018764-02l423mk	394	51	,	,	,
cord-018764-02l423mk	394	52	and	and	CC
cord-018764-02l423mk	394	53	lactate	lactate	NN
cord-018764-02l423mk	394	54	in	in	IN
cord-018764-02l423mk	394	55	patients	patient	NNS
cord-018764-02l423mk	394	56	in	in	IN
cord-018764-02l423mk	394	57	the	the	DT
cord-018764-02l423mk	394	58	pediatric	pediatric	JJ
cord-018764-02l423mk	394	59	intensive	intensive	JJ
cord-018764-02l423mk	394	60	care	care	NN
cord-018764-02l423mk	394	61	unit	unit	NN
cord-018764-02l423mk	394	62	Unidentified	unidentified	JJ
cord-018764-02l423mk	394	63	acids	acid	NNS
cord-018764-02l423mk	394	64	of	of	IN
cord-018764-02l423mk	394	65	strong	strong	JJ
cord-018764-02l423mk	394	66	prognostic	prognostic	JJ
cord-018764-02l423mk	394	67	significance	significance	NN
cord-018764-02l423mk	394	68	in	in	IN
cord-018764-02l423mk	394	69	severe	severe	JJ
cord-018764-02l423mk	394	70	malaria	malaria	NN
cord-018764-02l423mk	394	71	Glucose	glucose	NN
cord-018764-02l423mk	394	72	homeostasis	homeostasis	NN
cord-018764-02l423mk	394	73	in	in	IN
cord-018764-02l423mk	394	74	children	child	NNS
cord-018764-02l423mk	394	75	with	with	IN
cord-018764-02l423mk	394	76	falciparum	falciparum	NN
cord-018764-02l423mk	394	77	malaria	malaria	NN
cord-018764-02l423mk	394	78	:	:	:
cord-018764-02l423mk	394	79	precursor	precursor	NN
cord-018764-02l423mk	394	80	supply	supply	NN
cord-018764-02l423mk	394	81	limits	limit	VBZ
cord-018764-02l423mk	394	82	gluconeogenesis	gluconeogenesis	NN
cord-018764-02l423mk	394	83	and	and	CC
cord-018764-02l423mk	394	84	glucose	glucose	NN
cord-018764-02l423mk	394	85	production	production	NN
cord-018764-02l423mk	394	86	Hypoglycemia	hypoglycemia	NN
cord-018764-02l423mk	394	87	as	as	IN
cord-018764-02l423mk	394	88	a	a	DT
cord-018764-02l423mk	394	89	manifestation	manifestation	NN
cord-018764-02l423mk	394	90	of	of	IN
cord-018764-02l423mk	394	91	sepsis	sepsis	NN
cord-018764-02l423mk	394	92	Hypoglycaemia	Hypoglycaemia	NNP
cord-018764-02l423mk	394	93	is	be	VBZ
cord-018764-02l423mk	394	94	an	an	DT
cord-018764-02l423mk	394	95	important	important	JJ
cord-018764-02l423mk	394	96	complication	complication	NN
cord-018764-02l423mk	394	97	of	of	IN
cord-018764-02l423mk	394	98	falciparum	falciparum	NN
cord-018764-02l423mk	394	99	malaria	malaria	NN
cord-018764-02l423mk	394	100	Severe	severe	JJ
cord-018764-02l423mk	394	101	falciparum	falciparum	NN
cord-018764-02l423mk	394	102	malaria	malaria	NN
cord-018764-02l423mk	394	103	Intracranial	intracranial	JJ
cord-018764-02l423mk	394	104	pressure	pressure	NN
cord-018764-02l423mk	394	105	in	in	IN
cord-018764-02l423mk	394	106	childhood	childhood	NN
cord-018764-02l423mk	394	107	cerebral	cerebral	JJ
cord-018764-02l423mk	394	108	malaria	malaria	NN
cord-018764-02l423mk	394	109	Intracranial	intracranial	JJ
cord-018764-02l423mk	394	110	hypertension	hypertension	NN
cord-018764-02l423mk	394	111	in	in	IN
cord-018764-02l423mk	394	112	Africans	Africans	NNPS
cord-018764-02l423mk	394	113	with	with	IN
cord-018764-02l423mk	394	114	cerebral	cerebral	JJ
cord-018764-02l423mk	394	115	malaria	malaria	NN
cord-018764-02l423mk	394	116	Prognostic	prognostic	JJ
cord-018764-02l423mk	394	117	significance	significance	NN
cord-018764-02l423mk	394	118	and	and	CC
cord-018764-02l423mk	394	119	course	course	NN
cord-018764-02l423mk	394	120	of	of	IN
cord-018764-02l423mk	394	121	retinopathy	retinopathy	NN
cord-018764-02l423mk	394	122	in	in	IN
cord-018764-02l423mk	394	123	children	child	NNS
cord-018764-02l423mk	394	124	with	with	IN
cord-018764-02l423mk	394	125	severe	severe	JJ
cord-018764-02l423mk	394	126	malaria	malaria	NN
cord-018764-02l423mk	394	127	Blood	blood	NN
cord-018764-02l423mk	394	128	-	-	HYPH
cord-018764-02l423mk	394	129	brain	brain	NN
cord-018764-02l423mk	394	130	barrier	barrier	NN
cord-018764-02l423mk	394	131	in	in	IN
cord-018764-02l423mk	394	132	falciparum	falciparum	NN
cord-018764-02l423mk	394	133	malaria	malaria	NN
cord-018764-02l423mk	394	134	Breaking	break	VBG
cord-018764-02l423mk	394	135	down	down	RP
cord-018764-02l423mk	394	136	the	the	DT
cord-018764-02l423mk	394	137	blood	blood	NN
cord-018764-02l423mk	394	138	-	-	HYPH
cord-018764-02l423mk	394	139	brain	brain	NN
cord-018764-02l423mk	394	140	barrier	barrier	NN
cord-018764-02l423mk	394	141	:	:	:
cord-018764-02l423mk	394	142	signaling	signal	VBG
cord-018764-02l423mk	394	143	a	a	DT
cord-018764-02l423mk	394	144	path	path	NN
cord-018764-02l423mk	394	145	to	to	IN
cord-018764-02l423mk	394	146	cerebral	cerebral	JJ
cord-018764-02l423mk	394	147	malaria	malaria	NN
cord-018764-02l423mk	394	148	?	?	.
cord-018764-02l423mk	395	1	Evidence	evidence	NN
cord-018764-02l423mk	395	2	of	of	IN
cord-018764-02l423mk	395	3	blood	blood	NN
cord-018764-02l423mk	395	4	-	-	HYPH
cord-018764-02l423mk	395	5	brain	brain	NN
cord-018764-02l423mk	395	6	barrier	barrier	NN
cord-018764-02l423mk	395	7	dysfunction	dysfunction	NN
cord-018764-02l423mk	395	8	in	in	IN
cord-018764-02l423mk	395	9	human	human	JJ
cord-018764-02l423mk	395	10	cerebral	cerebral	JJ
cord-018764-02l423mk	395	11	malaria	malaria	NN
cord-018764-02l423mk	395	12	Function	function	NN
cord-018764-02l423mk	395	13	of	of	IN
cord-018764-02l423mk	395	14	the	the	DT
cord-018764-02l423mk	395	15	blood	blood	NN
cord-018764-02l423mk	395	16	-	-	HYPH
cord-018764-02l423mk	395	17	cerebrospinal	cerebrospinal	VBG
cord-018764-02l423mk	395	18	fluid	fluid	JJ
cord-018764-02l423mk	395	19	barrier	barrier	NN
cord-018764-02l423mk	395	20	in	in	IN
cord-018764-02l423mk	395	21	human	human	JJ
cord-018764-02l423mk	395	22	cerebral	cerebral	JJ
cord-018764-02l423mk	395	23	malaria	malaria	NN
cord-018764-02l423mk	395	24	:	:	:
cord-018764-02l423mk	395	25	rejection	rejection	NN
cord-018764-02l423mk	395	26	of	of	IN
cord-018764-02l423mk	395	27	the	the	DT
cord-018764-02l423mk	395	28	permeability	permeability	NN
cord-018764-02l423mk	395	29	hypothesis	hypothesis	NN
cord-018764-02l423mk	395	30	Blood	blood	NN
cord-018764-02l423mk	395	31	-	-	HYPH
cord-018764-02l423mk	395	32	brain	brain	NN
cord-018764-02l423mk	395	33	barrier	barrier	NN
cord-018764-02l423mk	395	34	function	function	NN
cord-018764-02l423mk	395	35	in	in	IN
cord-018764-02l423mk	395	36	cerebral	cerebral	JJ
cord-018764-02l423mk	395	37	malaria	malaria	NN
cord-018764-02l423mk	395	38	and	and	CC
cord-018764-02l423mk	395	39	CNS	CNS	NNP
cord-018764-02l423mk	395	40	infections	infection	NNS
cord-018764-02l423mk	395	41	in	in	IN
cord-018764-02l423mk	395	42	Vietnam	Vietnam	NNP
cord-018764-02l423mk	395	43	Edema	Edema	NNP
cord-018764-02l423mk	395	44	and	and	CC
cord-018764-02l423mk	395	45	brain	brain	NN
cord-018764-02l423mk	395	46	trauma	trauma	NN
cord-018764-02l423mk	395	47	Clinical	clinical	JJ
cord-018764-02l423mk	395	48	manifestations	manifestation	NNS
cord-018764-02l423mk	395	49	of	of	IN
cord-018764-02l423mk	395	50	severe	severe	JJ
cord-018764-02l423mk	395	51	malaria	malaria	NN
cord-018764-02l423mk	395	52	in	in	IN
cord-018764-02l423mk	395	53	the	the	DT
cord-018764-02l423mk	395	54	highlands	highlands	NNP
cord-018764-02l423mk	395	55	of	of	IN
cord-018764-02l423mk	395	56	southwestern	southwestern	JJ
cord-018764-02l423mk	395	57	Uganda	Uganda	NNP
cord-018764-02l423mk	395	58	Malaria	Malaria	NNP
cord-018764-02l423mk	395	59	:	:	:
cord-018764-02l423mk	395	60	pathogenicity	pathogenicity	NN
cord-018764-02l423mk	395	61	and	and	CC
cord-018764-02l423mk	395	62	disease	disease	NN
cord-018764-02l423mk	395	63	Outcome	outcome	NN
cord-018764-02l423mk	395	64	of	of	IN
cord-018764-02l423mk	395	65	stroke	stroke	NN
cord-018764-02l423mk	395	66	in	in	IN
cord-018764-02l423mk	395	67	Saudi	saudi	JJ
cord-018764-02l423mk	395	68	children	child	NNS
cord-018764-02l423mk	396	1	Brain	brain	NN
cord-018764-02l423mk	396	2	swelling	swelling	NN
cord-018764-02l423mk	396	3	and	and	CC
cord-018764-02l423mk	396	4	ischaemia	ischaemia	NN
cord-018764-02l423mk	396	5	in	in	IN
cord-018764-02l423mk	396	6	Kenyans	Kenyans	NNPS
cord-018764-02l423mk	396	7	with	with	IN
cord-018764-02l423mk	396	8	cerebral	cerebral	JJ
cord-018764-02l423mk	396	9	malaria	malaria	NN
cord-018764-02l423mk	396	10	Tissue	tissue	NN
cord-018764-02l423mk	396	11	distribution	distribution	NN
cord-018764-02l423mk	396	12	of	of	IN
cord-018764-02l423mk	396	13	migration	migration	NN
cord-018764-02l423mk	396	14	inhibitory	inhibitory	JJ
cord-018764-02l423mk	396	15	factor	factor	NN
cord-018764-02l423mk	396	16	and	and	CC
cord-018764-02l423mk	396	17	inducible	inducible	JJ
cord-018764-02l423mk	396	18	nitric	nitric	NN
cord-018764-02l423mk	396	19	oxide	oxide	NN
cord-018764-02l423mk	396	20	synthase	synthase	NN
cord-018764-02l423mk	396	21	in	in	IN
cord-018764-02l423mk	396	22	falciparum	falciparum	NN
cord-018764-02l423mk	396	23	malaria	malaria	NN
cord-018764-02l423mk	396	24	and	and	CC
cord-018764-02l423mk	396	25	sepsis	sepsis	NN
cord-018764-02l423mk	396	26	in	in	IN
cord-018764-02l423mk	396	27	African	african	JJ
cord-018764-02l423mk	396	28	children	child	NNS
cord-018764-02l423mk	396	29	Induction	Induction	NNP
cord-018764-02l423mk	396	30	of	of	IN
cord-018764-02l423mk	396	31	HO-1	HO-1	NNP
cord-018764-02l423mk	396	32	in	in	IN
cord-018764-02l423mk	396	33	tissue	tissue	NN
cord-018764-02l423mk	396	34	macrophages	macrophage	NNS
cord-018764-02l423mk	396	35	and	and	CC
cord-018764-02l423mk	396	36	monocytes	monocyte	NNS
cord-018764-02l423mk	396	37	in	in	IN
cord-018764-02l423mk	396	38	fatal	fatal	JJ
cord-018764-02l423mk	396	39	falciparum	falciparum	NN
cord-018764-02l423mk	396	40	malaria	malaria	NN
cord-018764-02l423mk	396	41	and	and	CC
cord-018764-02l423mk	396	42	sepsis	sepsis	NN
cord-018764-02l423mk	396	43	Tumor	tumor	NN
cord-018764-02l423mk	396	44	necrosis	necrosis	NN
cord-018764-02l423mk	396	45	factor	factor	NN
cord-018764-02l423mk	396	46	production	production	NN
cord-018764-02l423mk	396	47	in	in	IN
cord-018764-02l423mk	396	48	falciparum	falciparum	NN
cord-018764-02l423mk	396	49	malaria	malaria	NN
cord-018764-02l423mk	396	50	and	and	CC
cord-018764-02l423mk	396	51	its	-PRON-	PRP$
cord-018764-02l423mk	396	52	association	association	NN
cord-018764-02l423mk	396	53	with	with	IN
cord-018764-02l423mk	396	54	schizont	schizont	NNP
cord-018764-02l423mk	396	55	rupture	rupture	NN
cord-018764-02l423mk	397	1	Distinct	distinct	JJ
cord-018764-02l423mk	397	2	patterns	pattern	NNS
cord-018764-02l423mk	397	3	of	of	IN
cord-018764-02l423mk	397	4	cytokine	cytokine	NN
cord-018764-02l423mk	397	5	regulation	regulation	NN
cord-018764-02l423mk	397	6	in	in	IN
cord-018764-02l423mk	397	7	discrete	discrete	JJ
cord-018764-02l423mk	397	8	clinical	clinical	JJ
cord-018764-02l423mk	397	9	forms	form	NNS
cord-018764-02l423mk	397	10	of	of	IN
cord-018764-02l423mk	397	11	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	397	12	falciparum	falciparum	NN
cord-018764-02l423mk	397	13	malaria	malaria	NN
cord-018764-02l423mk	397	14	Tumor	tumor	NN
cord-018764-02l423mk	397	15	necrosis	necrosis	NN
cord-018764-02l423mk	397	16	factor	factor	NN
cord-018764-02l423mk	397	17	alpha	alpha	NN
cord-018764-02l423mk	397	18	in	in	IN
cord-018764-02l423mk	397	19	the	the	DT
cord-018764-02l423mk	397	20	pathogenesis	pathogenesis	NN
cord-018764-02l423mk	397	21	of	of	IN
cord-018764-02l423mk	397	22	cerebral	cerebral	JJ
cord-018764-02l423mk	397	23	malaria	malaria	NN
cord-018764-02l423mk	397	24	Variation	variation	NN
cord-018764-02l423mk	397	25	in	in	IN
cord-018764-02l423mk	397	26	the	the	DT
cord-018764-02l423mk	397	27	TNF	TNF	NNP
cord-018764-02l423mk	397	28	-	-	HYPH
cord-018764-02l423mk	397	29	alpha	alpha	NN
cord-018764-02l423mk	397	30	promoter	promoter	NN
cord-018764-02l423mk	397	31	region	region	NN
cord-018764-02l423mk	397	32	associated	associate	VBN
cord-018764-02l423mk	397	33	with	with	IN
cord-018764-02l423mk	397	34	susceptibility	susceptibility	NN
cord-018764-02l423mk	397	35	to	to	IN
cord-018764-02l423mk	397	36	cerebral	cerebral	JJ
cord-018764-02l423mk	397	37	malaria	malaria	NN
cord-018764-02l423mk	398	1	Possible	possible	JJ
cord-018764-02l423mk	398	2	central	central	JJ
cord-018764-02l423mk	398	3	role	role	NN
cord-018764-02l423mk	398	4	of	of	IN
cord-018764-02l423mk	398	5	nitric	nitric	JJ
cord-018764-02l423mk	398	6	oxide	oxide	NN
cord-018764-02l423mk	398	7	in	in	IN
cord-018764-02l423mk	398	8	conditions	condition	NNS
cord-018764-02l423mk	398	9	clinically	clinically	RB
cord-018764-02l423mk	398	10	similar	similar	JJ
cord-018764-02l423mk	398	11	to	to	IN
cord-018764-02l423mk	398	12	cerebral	cerebral	JJ
cord-018764-02l423mk	398	13	malaria	malaria	NN
cord-018764-02l423mk	398	14	Nitric	nitric	NN
cord-018764-02l423mk	398	15	oxide	oxide	NN
cord-018764-02l423mk	398	16	potently	potently	RB
cord-018764-02l423mk	398	17	and	and	CC
cord-018764-02l423mk	398	18	reversibly	reversibly	RB
cord-018764-02l423mk	398	19	deenergizes	deenergize	VBZ
cord-018764-02l423mk	398	20	mitochondria	mitochondrion	NNS
cord-018764-02l423mk	398	21	at	at	IN
cord-018764-02l423mk	398	22	low	low	JJ
cord-018764-02l423mk	398	23	oxygen	oxygen	NN
cord-018764-02l423mk	398	24	tension	tension	NN
cord-018764-02l423mk	398	25	Tumor	tumor	NN
cord-018764-02l423mk	398	26	necrosis	necrosis	NN
cord-018764-02l423mk	398	27	factor	factor	NN
cord-018764-02l423mk	398	28	-	-	HYPH
cord-018764-02l423mk	398	29	alpha	alpha	NN
cord-018764-02l423mk	398	30	and	and	CC
cord-018764-02l423mk	398	31	lipopolysaccharide	lipopolysaccharide	NN
cord-018764-02l423mk	398	32	enhance	enhance	VB
cord-018764-02l423mk	398	33	interferoninduced	interferoninduce	VBN
cord-018764-02l423mk	398	34	antichlamydial	antichlamydial	NNP
cord-018764-02l423mk	398	35	indoleamine	indoleamine	NN
cord-018764-02l423mk	398	36	dioxygenase	dioxygenase	NN
cord-018764-02l423mk	398	37	activity	activity	NN
cord-018764-02l423mk	398	38	independently	independently	RB
cord-018764-02l423mk	398	39	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-018764-02l423mk	398	40	induction	induction	NN
cord-018764-02l423mk	398	41	of	of	IN
cord-018764-02l423mk	398	42	indoleamine	indoleamine	NN
cord-018764-02l423mk	398	43	2,3-dioxygenase	2,3-dioxygenase	NNP
cord-018764-02l423mk	398	44	is	be	VBZ
cord-018764-02l423mk	398	45	mediated	mediate	VBN
cord-018764-02l423mk	398	46	dominantly	dominantly	RB
cord-018764-02l423mk	398	47	by	by	IN
cord-018764-02l423mk	398	48	an	an	DT
cord-018764-02l423mk	398	49	IFN	IFN	NNP
cord-018764-02l423mk	398	50	-	-	HYPH
cord-018764-02l423mk	398	51	gamma	gamma	NN
cord-018764-02l423mk	398	52	-	-	HYPH
cord-018764-02l423mk	398	53	independent	independent	JJ
cord-018764-02l423mk	398	54	mechanism	mechanism	NN
cord-018764-02l423mk	398	55	Metabolites	metabolite	NNS
cord-018764-02l423mk	398	56	of	of	IN
cord-018764-02l423mk	398	57	the	the	DT
cord-018764-02l423mk	398	58	kynurenine	kynurenine	JJ
cord-018764-02l423mk	398	59	pathway	pathway	NN
cord-018764-02l423mk	398	60	of	of	IN
cord-018764-02l423mk	398	61	tryptophan	tryptophan	NN
cord-018764-02l423mk	398	62	metabolism	metabolism	NN
cord-018764-02l423mk	398	63	in	in	IN
cord-018764-02l423mk	398	64	the	the	DT
cord-018764-02l423mk	398	65	cerebrospinal	cerebrospinal	JJ
cord-018764-02l423mk	398	66	fluid	fluid	NN
cord-018764-02l423mk	398	67	of	of	IN
cord-018764-02l423mk	398	68	Malawian	malawian	JJ
cord-018764-02l423mk	398	69	children	child	NNS
cord-018764-02l423mk	398	70	with	with	IN
cord-018764-02l423mk	398	71	malaria	malaria	NN
cord-018764-02l423mk	398	72	Cerebrospinal	cerebrospinal	NN
cord-018764-02l423mk	398	73	fluid	fluid	JJ
cord-018764-02l423mk	398	74	studies	study	NNS
cord-018764-02l423mk	398	75	in	in	IN
cord-018764-02l423mk	398	76	children	child	NNS
cord-018764-02l423mk	398	77	with	with	IN
cord-018764-02l423mk	398	78	cerebral	cerebral	JJ
cord-018764-02l423mk	398	79	malaria	malaria	NN
cord-018764-02l423mk	398	80	:	:	:
cord-018764-02l423mk	398	81	An	an	DT
cord-018764-02l423mk	398	82	excitotoxic	excitotoxic	JJ
cord-018764-02l423mk	398	83	mechanism	mechanism	NN
cord-018764-02l423mk	398	84	?	?	.
cord-018764-02l423mk	399	1	Does	do	VBZ
cord-018764-02l423mk	399	2	malarial	malarial	JJ
cord-018764-02l423mk	399	3	tolerance	tolerance	NN
cord-018764-02l423mk	399	4	,	,	,
cord-018764-02l423mk	399	5	through	through	IN
cord-018764-02l423mk	399	6	nitric	nitric	NN
cord-018764-02l423mk	399	7	oxide	oxide	NN
cord-018764-02l423mk	399	8	,	,	,
cord-018764-02l423mk	399	9	explain	explain	VB
cord-018764-02l423mk	399	10	the	the	DT
cord-018764-02l423mk	399	11	low	low	JJ
cord-018764-02l423mk	399	12	incidence	incidence	NN
cord-018764-02l423mk	399	13	of	of	IN
cord-018764-02l423mk	399	14	autoimmune	autoimmune	JJ
cord-018764-02l423mk	399	15	disease	disease	NN
cord-018764-02l423mk	399	16	in	in	IN
cord-018764-02l423mk	399	17	tropical	tropical	JJ
cord-018764-02l423mk	399	18	Africa	Africa	NNP
cord-018764-02l423mk	400	1	The	the	DT
cord-018764-02l423mk	400	2	role	role	NN
cord-018764-02l423mk	400	3	of	of	IN
cord-018764-02l423mk	400	4	cytokines	cytokine	NNS
cord-018764-02l423mk	400	5	in	in	IN
cord-018764-02l423mk	400	6	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	400	7	vivax	vivax	JJ
cord-018764-02l423mk	400	8	malaria	malaria	NN
cord-018764-02l423mk	401	1	The	the	DT
cord-018764-02l423mk	401	2	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	401	3	associated	associate	VBN
cord-018764-02l423mk	401	4	with	with	IN
cord-018764-02l423mk	401	5	septic	septic	JJ
cord-018764-02l423mk	401	6	illness	illness	NN
cord-018764-02l423mk	401	7	Tumor	tumor	NN
cord-018764-02l423mk	401	8	necrosis	necrosis	NN
cord-018764-02l423mk	401	9	factor	factor	NN
cord-018764-02l423mk	401	10	alpha	alpha	NN
cord-018764-02l423mk	401	11	antibody	antibody	NN
cord-018764-02l423mk	401	12	prevents	prevent	VBZ
cord-018764-02l423mk	401	13	brain	brain	NN
cord-018764-02l423mk	401	14	damage	damage	NN
cord-018764-02l423mk	401	15	of	of	IN
cord-018764-02l423mk	401	16	rats	rat	NNS
cord-018764-02l423mk	401	17	with	with	IN
cord-018764-02l423mk	401	18	acute	acute	JJ
cord-018764-02l423mk	401	19	necrotizing	necrotize	VBG
cord-018764-02l423mk	401	20	pancreatitis	pancreatitis	NN
cord-018764-02l423mk	401	21	Progress	Progress	NNP
cord-018764-02l423mk	401	22	in	in	IN
cord-018764-02l423mk	401	23	clinical	clinical	JJ
cord-018764-02l423mk	401	24	neurosciences	neuroscience	NNS
cord-018764-02l423mk	401	25	:	:	:
cord-018764-02l423mk	401	26	sepsis	sepsis	NN
cord-018764-02l423mk	401	27	-	-	HYPH
cord-018764-02l423mk	401	28	associated	associate	VBN
cord-018764-02l423mk	401	29	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	401	30	:	:	:
cord-018764-02l423mk	401	31	evolving	evolve	VBG
cord-018764-02l423mk	401	32	concepts	concept	NNS
cord-018764-02l423mk	401	33	Influenza	influenza	NN
cord-018764-02l423mk	401	34	-	-	HYPH
cord-018764-02l423mk	401	35	associated	associate	VBN
cord-018764-02l423mk	401	36	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	401	37	:	:	:
cord-018764-02l423mk	402	1	No	no	DT
cord-018764-02l423mk	402	2	evidence	evidence	NN
cord-018764-02l423mk	402	3	for	for	IN
cord-018764-02l423mk	402	4	neuroinvasion	neuroinvasion	NN
cord-018764-02l423mk	402	5	by	by	IN
cord-018764-02l423mk	402	6	influenza	influenza	NN
cord-018764-02l423mk	402	7	virus	virus	NN
cord-018764-02l423mk	402	8	nor	nor	CC
cord-018764-02l423mk	402	9	for	for	IN
cord-018764-02l423mk	402	10	reactivation	reactivation	NN
cord-018764-02l423mk	402	11	of	of	IN
cord-018764-02l423mk	402	12	human	human	JJ
cord-018764-02l423mk	402	13	herpesvirus	herpesvirus	NN
cord-018764-02l423mk	402	14	6	6	CD
cord-018764-02l423mk	402	15	or	or	CC
cord-018764-02l423mk	402	16	7	7	CD
cord-018764-02l423mk	402	17	Encephalitis	encephaliti	NNS
cord-018764-02l423mk	402	18	and	and	CC
cord-018764-02l423mk	402	19	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	402	20	associated	associate	VBN
cord-018764-02l423mk	402	21	with	with	IN
cord-018764-02l423mk	402	22	an	an	DT
cord-018764-02l423mk	402	23	influenza	influenza	NN
cord-018764-02l423mk	402	24	epidemic	epidemic	NN
cord-018764-02l423mk	402	25	in	in	IN
cord-018764-02l423mk	402	26	Japan	Japan	NNP
cord-018764-02l423mk	402	27	Cerebrospinal	Cerebrospinal	NNP
cord-018764-02l423mk	402	28	fluid	fluid	NN
cord-018764-02l423mk	402	29	and	and	CC
cord-018764-02l423mk	402	30	serum	serum	NN
cord-018764-02l423mk	402	31	levels	level	NNS
cord-018764-02l423mk	402	32	of	of	IN
cord-018764-02l423mk	402	33	cytokines	cytokine	NNS
cord-018764-02l423mk	402	34	and	and	CC
cord-018764-02l423mk	402	35	soluble	soluble	JJ
cord-018764-02l423mk	402	36	tumor	tumor	NN
cord-018764-02l423mk	402	37	necrosis	necrosis	NN
cord-018764-02l423mk	402	38	factor	factor	NN
cord-018764-02l423mk	402	39	receptor	receptor	NN
cord-018764-02l423mk	402	40	in	in	IN
cord-018764-02l423mk	402	41	influenza	influenza	NN
cord-018764-02l423mk	402	42	virus	virus	NN
cord-018764-02l423mk	402	43	-	-	HYPH
cord-018764-02l423mk	402	44	associated	associate	VBN
cord-018764-02l423mk	402	45	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	402	46	Analysis	analysis	NN
cord-018764-02l423mk	402	47	of	of	IN
cord-018764-02l423mk	402	48	cytokine	cytokine	NN
cord-018764-02l423mk	402	49	levels	level	NNS
cord-018764-02l423mk	402	50	and	and	CC
cord-018764-02l423mk	402	51	NF-[kappa]B	nf-[kappa]b	CD
cord-018764-02l423mk	402	52	activation	activation	NN
cord-018764-02l423mk	402	53	in	in	IN
cord-018764-02l423mk	402	54	peripheral	peripheral	JJ
cord-018764-02l423mk	402	55	blood	blood	NN
cord-018764-02l423mk	402	56	mononuclear	mononuclear	NN
cord-018764-02l423mk	402	57	cells	cell	NNS
cord-018764-02l423mk	402	58	in	in	IN
cord-018764-02l423mk	402	59	influenza	influenza	NN
cord-018764-02l423mk	402	60	virus	virus	NN
cord-018764-02l423mk	402	61	-	-	HYPH
cord-018764-02l423mk	402	62	associated	associate	VBN
cord-018764-02l423mk	402	63	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	402	64	Cytochrome	cytochrome	NN
cord-018764-02l423mk	402	65	c	c	NN
cord-018764-02l423mk	402	66	and	and	CC
cord-018764-02l423mk	403	1	tumor	tumor	NN
cord-018764-02l423mk	403	2	necrosis	necrosis	NN
cord-018764-02l423mk	403	3	factor	factor	NN
cord-018764-02l423mk	403	4	-	-	HYPH
cord-018764-02l423mk	403	5	alpha	alpha	NN
cord-018764-02l423mk	403	6	values	value	NNS
cord-018764-02l423mk	403	7	in	in	IN
cord-018764-02l423mk	403	8	serum	serum	NN
cord-018764-02l423mk	403	9	and	and	CC
cord-018764-02l423mk	403	10	cerebrospinal	cerebrospinal	JJ
cord-018764-02l423mk	403	11	fluid	fluid	NN
cord-018764-02l423mk	403	12	of	of	IN
cord-018764-02l423mk	403	13	patients	patient	NNS
cord-018764-02l423mk	403	14	with	with	IN
cord-018764-02l423mk	403	15	influenza	influenza	NN
cord-018764-02l423mk	403	16	-	-	HYPH
cord-018764-02l423mk	403	17	associated	associate	VBN
cord-018764-02l423mk	403	18	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	403	19	High	high	JJ
cord-018764-02l423mk	403	20	concentration	concentration	NN
cord-018764-02l423mk	403	21	of	of	IN
cord-018764-02l423mk	403	22	serum	serum	NN
cord-018764-02l423mk	403	23	nitrite/	nitrite/	CD
cord-018764-02l423mk	403	24	nitrate	nitrate	NN
cord-018764-02l423mk	403	25	obtained	obtain	VBN
cord-018764-02l423mk	403	26	from	from	IN
cord-018764-02l423mk	403	27	patients	patient	NNS
cord-018764-02l423mk	403	28	with	with	IN
cord-018764-02l423mk	403	29	influenza	influenza	NN
cord-018764-02l423mk	403	30	-	-	HYPH
cord-018764-02l423mk	403	31	associated	associate	VBN
cord-018764-02l423mk	403	32	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	403	33	Apoptosis	apoptosis	NN
cord-018764-02l423mk	403	34	and	and	CC
cord-018764-02l423mk	403	35	microglial	microglial	JJ
cord-018764-02l423mk	403	36	activation	activation	NN
cord-018764-02l423mk	403	37	in	in	IN
cord-018764-02l423mk	403	38	influenza	influenza	NN
cord-018764-02l423mk	403	39	encephalopathy	encephalopathy	NN
cord-018764-02l423mk	403	40	Pathogenesis	Pathogenesis	NNP
cord-018764-02l423mk	403	41	,	,	,
cord-018764-02l423mk	403	42	clinical	clinical	JJ
cord-018764-02l423mk	403	43	features	feature	NNS
cord-018764-02l423mk	403	44	,	,	,
cord-018764-02l423mk	403	45	and	and	CC
cord-018764-02l423mk	403	46	neurological	neurological	JJ
cord-018764-02l423mk	403	47	outcome	outcome	NN
cord-018764-02l423mk	403	48	of	of	IN
cord-018764-02l423mk	403	49	cerebral	cerebral	JJ
cord-018764-02l423mk	403	50	malaria	malaria	NN
cord-018764-02l423mk	403	51	Antibodies	antibody	NNS
cord-018764-02l423mk	403	52	to	to	TO
cord-018764-02l423mk	403	53	voltage	voltage	VB
cord-018764-02l423mk	403	54	-	-	HYPH
cord-018764-02l423mk	403	55	gated	gate	VBN
cord-018764-02l423mk	403	56	calcium	calcium	NN
cord-018764-02l423mk	403	57	channels	channel	NNS
cord-018764-02l423mk	403	58	in	in	IN
cord-018764-02l423mk	403	59	children	child	NNS
cord-018764-02l423mk	403	60	with	with	IN
cord-018764-02l423mk	403	61	falciparum	falciparum	NN
cord-018764-02l423mk	403	62	malaria	malaria	NN
cord-018764-02l423mk	404	1	The	the	DT
cord-018764-02l423mk	404	2	rate	rate	NN
cord-018764-02l423mk	404	3	of	of	IN
cord-018764-02l423mk	404	4	mutation	mutation	NN
cord-018764-02l423mk	404	5	of	of	IN
cord-018764-02l423mk	404	6	human	human	JJ
cord-018764-02l423mk	404	7	genes	gene	NNS
cord-018764-02l423mk	405	1	Common	common	JJ
cord-018764-02l423mk	405	2	west	west	JJ
cord-018764-02l423mk	405	3	African	African	NNP
cord-018764-02l423mk	405	4	HLA	HLA	NNP
cord-018764-02l423mk	405	5	antigens	antigen	NNS
cord-018764-02l423mk	405	6	are	be	VBP
cord-018764-02l423mk	405	7	associated	associate	VBN
cord-018764-02l423mk	405	8	with	with	IN
cord-018764-02l423mk	405	9	protection	protection	NN
cord-018764-02l423mk	405	10	from	from	IN
cord-018764-02l423mk	405	11	severe	severe	JJ
cord-018764-02l423mk	405	12	malaria	malaria	NN
cord-018764-02l423mk	405	13	Hemoglobin	hemoglobin	NN
cord-018764-02l423mk	405	14	C	C	NNP
cord-018764-02l423mk	405	15	associated	associate	VBN
cord-018764-02l423mk	405	16	with	with	IN
cord-018764-02l423mk	405	17	protection	protection	NN
cord-018764-02l423mk	405	18	from	from	IN
cord-018764-02l423mk	405	19	severe	severe	JJ
cord-018764-02l423mk	405	20	malaria	malaria	NN
cord-018764-02l423mk	405	21	in	in	IN
cord-018764-02l423mk	405	22	the	the	DT
cord-018764-02l423mk	405	23	Dogon	Dogon	NNP
cord-018764-02l423mk	405	24	of	of	IN
cord-018764-02l423mk	405	25	Mali	Mali	NNP
cord-018764-02l423mk	405	26	,	,	,
cord-018764-02l423mk	405	27	a	a	DT
cord-018764-02l423mk	405	28	West	west	JJ
cord-018764-02l423mk	405	29	African	african	JJ
cord-018764-02l423mk	405	30	population	population	NN
cord-018764-02l423mk	405	31	with	with	IN
cord-018764-02l423mk	405	32	a	a	DT
cord-018764-02l423mk	405	33	low	low	JJ
cord-018764-02l423mk	405	34	prevalence	prevalence	NN
cord-018764-02l423mk	405	35	of	of	IN
cord-018764-02l423mk	405	36	hemoglobin	hemoglobin	NN
cord-018764-02l423mk	405	37	S	S	NNP
cord-018764-02l423mk	405	38	Haemoglobin	Haemoglobin	NNP
cord-018764-02l423mk	405	39	C	C	NNP
cord-018764-02l423mk	405	40	protects	protect	VBZ
cord-018764-02l423mk	405	41	against	against	IN
cord-018764-02l423mk	405	42	clinical	clinical	JJ
cord-018764-02l423mk	405	43	Plasmodium	plasmodium	NN
cord-018764-02l423mk	405	44	falciparum	falciparum	NN
cord-018764-02l423mk	405	45	malaria	malaria	NN
cord-018764-02l423mk	405	46	Influence	influence	NN
cord-018764-02l423mk	405	47	of	of	IN
cord-018764-02l423mk	405	48	hemoglobin	hemoglobin	NN
cord-018764-02l423mk	405	49	E	e	NN
cord-018764-02l423mk	405	50	trait	trait	NN
cord-018764-02l423mk	405	51	on	on	IN
cord-018764-02l423mk	405	52	the	the	DT
cord-018764-02l423mk	405	53	severity	severity	NN
cord-018764-02l423mk	405	54	of	of	IN
cord-018764-02l423mk	405	55	falciparum	falciparum	NN
cord-018764-02l423mk	405	56	malaria	malaria	NNP
cord-018764-02l423mk	405	57	Natural	Natural	NNP
cord-018764-02l423mk	405	58	selection	selection	NN
cord-018764-02l423mk	405	59	of	of	IN
cord-018764-02l423mk	405	60	hemi	hemi	NNP
cord-018764-02l423mk	405	61	-	-	:
cord-018764-02l423mk	405	62	and	and	CC
cord-018764-02l423mk	405	63	heterozygotes	heterozygote	NNS
cord-018764-02l423mk	405	64	for	for	IN
cord-018764-02l423mk	405	65	G6PD	G6PD	NNP
cord-018764-02l423mk	405	66	deficiency	deficiency	NN
cord-018764-02l423mk	405	67	in	in	IN
cord-018764-02l423mk	405	68	Africa	Africa	NNP
cord-018764-02l423mk	405	69	by	by	IN
cord-018764-02l423mk	405	70	resistance	resistance	NN
cord-018764-02l423mk	405	71	to	to	IN
cord-018764-02l423mk	405	72	severe	severe	JJ
cord-018764-02l423mk	405	73	malaria	malaria	NN
cord-018764-02l423mk	405	74	Cellular	cellular	JJ
cord-018764-02l423mk	405	75	mechanism	mechanism	NN
cord-018764-02l423mk	405	76	for	for	IN
cord-018764-02l423mk	405	77	the	the	DT
cord-018764-02l423mk	405	78	protective	protective	JJ
cord-018764-02l423mk	405	79	effect	effect	NN
cord-018764-02l423mk	405	80	of	of	IN
cord-018764-02l423mk	405	81	haemoglobin	haemoglobin	NN
cord-018764-02l423mk	405	82	S	S	NNP
cord-018764-02l423mk	405	83	against	against	IN
cord-018764-02l423mk	405	84	P.	P.	NNP
cord-018764-02l423mk	405	85	falciparum	falciparum	NN
cord-018764-02l423mk	405	86	malaria	malaria	NN
cord-018764-02l423mk	405	87	Early	early	JJ
cord-018764-02l423mk	405	88	phagocytosis	phagocytosis	NN
cord-018764-02l423mk	405	89	of	of	IN
cord-018764-02l423mk	405	90	glucose-6-phosphate	glucose-6-phosphate	JJ
cord-018764-02l423mk	405	91	dehydrogenase	dehydrogenase	NN
cord-018764-02l423mk	406	1	(	(	-LRB-
cord-018764-02l423mk	406	2	G6PD)-deficient	G6PD)-deficient	NNP
cord-018764-02l423mk	406	3	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	406	4	parasitized	parasitize	VBN
cord-018764-02l423mk	406	5	by	by	IN
cord-018764-02l423mk	406	6	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	406	7	falciparum	falciparum	NNS
cord-018764-02l423mk	406	8	may	may	MD
cord-018764-02l423mk	406	9	explain	explain	VB
cord-018764-02l423mk	406	10	malaria	malaria	NN
cord-018764-02l423mk	406	11	protection	protection	NN
cord-018764-02l423mk	406	12	in	in	IN
cord-018764-02l423mk	406	13	G6PD	G6PD	NNP
cord-018764-02l423mk	406	14	deficiency	deficiency	NN
cord-018764-02l423mk	407	1	Lymphoproliferative	lymphoproliferative	JJ
cord-018764-02l423mk	407	2	responses	response	NNS
cord-018764-02l423mk	407	3	to	to	IN
cord-018764-02l423mk	407	4	Plasmodium	plasmodium	NN
cord-018764-02l423mk	407	5	falciparum	falciparum	NN
cord-018764-02l423mk	407	6	antigens	antigen	NNS
cord-018764-02l423mk	407	7	in	in	IN
cord-018764-02l423mk	407	8	children	child	NNS
cord-018764-02l423mk	407	9	with	with	IN
cord-018764-02l423mk	407	10	and	and	CC
cord-018764-02l423mk	407	11	without	without	IN
cord-018764-02l423mk	407	12	the	the	DT
cord-018764-02l423mk	407	13	sickle	sickle	NN
cord-018764-02l423mk	407	14	cell	cell	NN
cord-018764-02l423mk	407	15	trait	trait	NN
cord-018764-02l423mk	407	16	Abnormal	abnormal	JJ
cord-018764-02l423mk	407	17	display	display	NN
cord-018764-02l423mk	407	18	of	of	IN
cord-018764-02l423mk	407	19	PfEMP-1	PfEMP-1	NNP
cord-018764-02l423mk	407	20	on	on	IN
cord-018764-02l423mk	407	21	erythrocytes	erythrocyte	NNS
cord-018764-02l423mk	407	22	carrying	carry	VBG
cord-018764-02l423mk	407	23	haemoglobin	haemoglobin	NN
cord-018764-02l423mk	407	24	C	C	NNP
cord-018764-02l423mk	407	25	may	may	MD
cord-018764-02l423mk	407	26	protect	protect	VB
cord-018764-02l423mk	407	27	against	against	IN
cord-018764-02l423mk	407	28	malaria	malaria	NN
cord-018764-02l423mk	407	29	A	a	DT
cord-018764-02l423mk	407	30	new	new	JJ
cord-018764-02l423mk	407	31	look	look	NN
cord-018764-02l423mk	407	32	at	at	IN
cord-018764-02l423mk	407	33	the	the	DT
cord-018764-02l423mk	407	34	protection	protection	NN
cord-018764-02l423mk	407	35	of	of	IN
cord-018764-02l423mk	407	36	hemoglobin	hemoglobin	NN
cord-018764-02l423mk	407	37	AS	AS	NNP
cord-018764-02l423mk	407	38	and	and	CC
cord-018764-02l423mk	407	39	AC	ac	NN
cord-018764-02l423mk	407	40	genotypes	genotype	NNS
cord-018764-02l423mk	407	41	against	against	IN
cord-018764-02l423mk	407	42	Plasmodium	plasmodium	NN
cord-018764-02l423mk	407	43	falciparum	falciparum	NN
cord-018764-02l423mk	407	44	infection	infection	NN
cord-018764-02l423mk	407	45	:	:	:
cord-018764-02l423mk	407	46	a	a	DT
cord-018764-02l423mk	407	47	census	census	NN
cord-018764-02l423mk	407	48	tract	tract	NN
cord-018764-02l423mk	407	49	approach	approach	NN
cord-018764-02l423mk	407	50	Hemoglobin	Hemoglobin	NNP
cord-018764-02l423mk	407	51	C	C	NNP
cord-018764-02l423mk	407	52	and	and	CC
cord-018764-02l423mk	407	53	resistance	resistance	NN
cord-018764-02l423mk	407	54	to	to	IN
cord-018764-02l423mk	407	55	severe	severe	JJ
cord-018764-02l423mk	407	56	malaria	malaria	NN
cord-018764-02l423mk	407	57	in	in	IN
cord-018764-02l423mk	407	58	Ghanaian	ghanaian	JJ
cord-018764-02l423mk	407	59	children	child	NNS
cord-018764-02l423mk	407	60	Red	red	JJ
cord-018764-02l423mk	407	61	blood	blood	NN
cord-018764-02l423mk	407	62	cells	cell	NNS
cord-018764-02l423mk	407	63	that	that	WDT
cord-018764-02l423mk	407	64	do	do	VBP
cord-018764-02l423mk	407	65	and	and	CC
cord-018764-02l423mk	407	66	red	red	JJ
cord-018764-02l423mk	407	67	blood	blood	NN
cord-018764-02l423mk	407	68	cells	cell	NNS
cord-018764-02l423mk	407	69	that	that	WDT
cord-018764-02l423mk	407	70	do	do	VBP
cord-018764-02l423mk	407	71	n't	not	RB
cord-018764-02l423mk	407	72	:	:	:
cord-018764-02l423mk	407	73	how	how	WRB
cord-018764-02l423mk	407	74	to	to	TO
cord-018764-02l423mk	407	75	resist	resist	VB
cord-018764-02l423mk	407	76	a	a	DT
cord-018764-02l423mk	407	77	persistent	persistent	JJ
cord-018764-02l423mk	407	78	parasite	parasite	NN
cord-018764-02l423mk	407	79	The	the	DT
cord-018764-02l423mk	407	80	effect	effect	NN
cord-018764-02l423mk	407	81	of	of	IN
cord-018764-02l423mk	407	82	alpha+-thalassaemia	alpha+-thalassaemia	NNP
cord-018764-02l423mk	407	83	on	on	IN
cord-018764-02l423mk	407	84	the	the	DT
cord-018764-02l423mk	407	85	incidence	incidence	NN
cord-018764-02l423mk	407	86	of	of	IN
cord-018764-02l423mk	407	87	malaria	malaria	NN
cord-018764-02l423mk	407	88	and	and	CC
cord-018764-02l423mk	407	89	other	other	JJ
cord-018764-02l423mk	407	90	diseases	disease	NNS
cord-018764-02l423mk	407	91	in	in	IN
cord-018764-02l423mk	407	92	children	child	NNS
cord-018764-02l423mk	407	93	living	live	VBG
cord-018764-02l423mk	407	94	on	on	IN
cord-018764-02l423mk	407	95	the	the	DT
cord-018764-02l423mk	407	96	coast	coast	NN
cord-018764-02l423mk	407	97	of	of	IN
cord-018764-02l423mk	407	98	Kenya	Kenya	NNP
cord-018764-02l423mk	407	99	High	High	NNP
cord-018764-02l423mk	407	100	incidence	incidence	NN
cord-018764-02l423mk	407	101	of	of	IN
cord-018764-02l423mk	407	102	malaria	malaria	NN
cord-018764-02l423mk	407	103	in	in	IN
cord-018764-02l423mk	407	104	alpha	alpha	JJ
cord-018764-02l423mk	407	105	-	-	HYPH
cord-018764-02l423mk	407	106	thalassaemic	thalassaemic	JJ
cord-018764-02l423mk	407	107	children	child	NNS
cord-018764-02l423mk	407	108	High	high	JJ
cord-018764-02l423mk	407	109	prevalence	prevalence	NN
cord-018764-02l423mk	407	110	of	of	IN
cord-018764-02l423mk	407	111	human	human	JJ
cord-018764-02l423mk	407	112	antibodies	antibody	NNS
cord-018764-02l423mk	407	113	to	to	IN
cord-018764-02l423mk	407	114	recombinant	recombinant	JJ
cord-018764-02l423mk	407	115	Duffy	Duffy	NNP
cord-018764-02l423mk	407	116	binding	binding	NN
cord-018764-02l423mk	407	117	-	-	HYPH
cord-018764-02l423mk	407	118	like	like	JJ
cord-018764-02l423mk	407	119	alpha	alpha	NN
cord-018764-02l423mk	407	120	domains	domain	NNS
cord-018764-02l423mk	407	121	of	of	IN
cord-018764-02l423mk	407	122	the	the	DT
cord-018764-02l423mk	407	123	Plasmodium	Plasmodium	NNP
cord-018764-02l423mk	407	124	falciparum	falciparum	NN
cord-018764-02l423mk	407	125	-	-	HYPH
cord-018764-02l423mk	407	126	infected	infect	VBN
cord-018764-02l423mk	407	127	erythrocyte	erythrocyte	NN
cord-018764-02l423mk	407	128	membrane	membrane	NN
cord-018764-02l423mk	407	129	protein	protein	NN
cord-018764-02l423mk	407	130	1	1	CD
cord-018764-02l423mk	407	131	in	in	IN
cord-018764-02l423mk	407	132	semi	semi	JJ
cord-018764-02l423mk	407	133	-	-	JJ
cord-018764-02l423mk	407	134	immune	immune	JJ
cord-018764-02l423mk	407	135	adults	adult	NNS
cord-018764-02l423mk	407	136	compared	compare	VBN
cord-018764-02l423mk	407	137	to	to	IN
cord-018764-02l423mk	407	138	that	that	DT
cord-018764-02l423mk	407	139	in	in	IN
cord-018764-02l423mk	407	140	non	non	JJ
cord-018764-02l423mk	407	141	-	-	JJ
cord-018764-02l423mk	407	142	immune	immune	JJ
cord-018764-02l423mk	407	143	children	child	NNS
cord-018764-02l423mk	407	144	Seasonal	seasonal	JJ
cord-018764-02l423mk	407	145	childhood	childhood	NN
cord-018764-02l423mk	407	146	anaemia	anaemia	NN
cord-018764-02l423mk	407	147	in	in	IN
cord-018764-02l423mk	407	148	West	West	NNP
cord-018764-02l423mk	407	149	Africa	Africa	NNP
cord-018764-02l423mk	407	150	is	be	VBZ
cord-018764-02l423mk	407	151	associated	associate	VBN
cord-018764-02l423mk	407	152	with	with	IN
cord-018764-02l423mk	407	153	the	the	DT
cord-018764-02l423mk	407	154	haptoglobin	haptoglobin	NN
cord-018764-02l423mk	407	155	2	2	CD
cord-018764-02l423mk	407	156	-	-	SYM
cord-018764-02l423mk	407	157	2	2	CD
cord-018764-02l423mk	407	158	genotype	genotype	NN
cord-018764-02l423mk	407	159	Negative	negative	JJ
cord-018764-02l423mk	407	160	epistasis	epistasis	NN
cord-018764-02l423mk	407	161	between	between	IN
cord-018764-02l423mk	407	162	the	the	DT
cord-018764-02l423mk	407	163	malaria	malaria	NN
cord-018764-02l423mk	407	164	-	-	HYPH
cord-018764-02l423mk	407	165	protective	protective	JJ
cord-018764-02l423mk	407	166	effects	effect	NNS
cord-018764-02l423mk	407	167	of	of	IN
cord-018764-02l423mk	407	168	alpha(+)-thalassemia	alpha(+)-thalassemia	NN
cord-018764-02l423mk	407	169	and	and	CC
cord-018764-02l423mk	407	170	the	the	DT
cord-018764-02l423mk	407	171	sickle	sickle	NN
cord-018764-02l423mk	407	172	cell	cell	NN
cord-018764-02l423mk	407	173	trait	trait	NN
cord-018764-02l423mk	407	174	Reversing	reverse	VBG
cord-018764-02l423mk	407	175	established	establish	VBN
cord-018764-02l423mk	407	176	sepsis	sepsis	NN
cord-018764-02l423mk	407	177	with	with	IN
cord-018764-02l423mk	407	178	antagonists	antagonist	NNS
cord-018764-02l423mk	407	179	of	of	IN
cord-018764-02l423mk	407	180	endogenous	endogenous	JJ
cord-018764-02l423mk	407	181	high	high	JJ
cord-018764-02l423mk	407	182	-	-	HYPH
cord-018764-02l423mk	407	183	mobility	mobility	NN
cord-018764-02l423mk	407	184	group	group	NN
cord-018764-02l423mk	407	185	box	box	NN
cord-018764-02l423mk	407	186	1	1	CD
cord-018764-02l423mk	407	187	Ethyl	ethyl	NN
cord-018764-02l423mk	407	188	pyruvate	pyruvate	NN
cord-018764-02l423mk	407	189	prevents	prevent	VBZ
cord-018764-02l423mk	407	190	lethality	lethality	NN
cord-018764-02l423mk	407	191	in	in	IN
cord-018764-02l423mk	407	192	mice	mouse	NNS
cord-018764-02l423mk	407	193	with	with	IN
cord-018764-02l423mk	407	194	established	establish	VBN
cord-018764-02l423mk	407	195	lethal	lethal	JJ
cord-018764-02l423mk	407	196	sepsis	sepsis	NN
cord-018764-02l423mk	407	197	and	and	CC
cord-018764-02l423mk	407	198	systemic	systemic	JJ
cord-018764-02l423mk	407	199	inflammation	inflammation	NN
cord-018764-02l423mk	408	1	Randomized	randomized	JJ
cord-018764-02l423mk	408	2	trial	trial	NN
cord-018764-02l423mk	408	3	of	of	IN
cord-018764-02l423mk	408	4	volume	volume	NN
cord-018764-02l423mk	408	5	expansion	expansion	NN
cord-018764-02l423mk	408	6	with	with	IN
cord-018764-02l423mk	408	7	albumin	albumin	NN
cord-018764-02l423mk	408	8	or	or	CC
cord-018764-02l423mk	408	9	saline	saline	NN
cord-018764-02l423mk	408	10	in	in	IN
cord-018764-02l423mk	408	11	children	child	NNS
cord-018764-02l423mk	408	12	with	with	IN
cord-018764-02l423mk	408	13	severe	severe	JJ
cord-018764-02l423mk	408	14	malaria	malaria	NN
cord-018764-02l423mk	408	15	:	:	:
cord-018764-02l423mk	408	16	preliminary	preliminary	JJ
cord-018764-02l423mk	408	17	evidence	evidence	NN
cord-018764-02l423mk	408	18	of	of	IN
cord-018764-02l423mk	408	19	albumin	albumin	NN
cord-018764-02l423mk	408	20	benefit	benefit	NN
cord-018764-02l423mk	408	21	Pharmacokinetics	Pharmacokinetics	NNP
cord-018764-02l423mk	408	22	and	and	CC
cord-018764-02l423mk	408	23	pharmacodynamics	pharmacodynamic	NNS
cord-018764-02l423mk	408	24	of	of	IN
cord-018764-02l423mk	408	25	dichloroacetate	dichloroacetate	NN
cord-018764-02l423mk	408	26	in	in	IN
cord-018764-02l423mk	408	27	children	child	NNS
cord-018764-02l423mk	408	28	with	with	IN
cord-018764-02l423mk	408	29	lactic	lactic	JJ
cord-018764-02l423mk	408	30	acidosis	acidosis	NN
cord-018764-02l423mk	408	31	due	due	IN
cord-018764-02l423mk	408	32	to	to	IN
cord-018764-02l423mk	408	33	severe	severe	JJ
cord-018764-02l423mk	408	34	malaria	malaria	NN
cord-018764-02l423mk	408	35	Oxidative	oxidative	JJ
cord-018764-02l423mk	408	36	stress	stress	NN
cord-018764-02l423mk	408	37	and	and	CC
cord-018764-02l423mk	408	38	rheology	rheology	NN
cord-018764-02l423mk	408	39	in	in	IN
cord-018764-02l423mk	408	40	severe	severe	JJ
cord-018764-02l423mk	408	41	malaria	malaria	NN
cord-018764-02l423mk	409	1	A	a	DT
cord-018764-02l423mk	409	2	pilot	pilot	NN
cord-018764-02l423mk	409	3	study	study	NN
cord-018764-02l423mk	409	4	of	of	IN
cord-018764-02l423mk	409	5	N	N	NNP
cord-018764-02l423mk	409	6	-	-	HYPH
cord-018764-02l423mk	409	7	acetylcysteine	acetylcysteine	NN
cord-018764-02l423mk	409	8	as	as	IN
cord-018764-02l423mk	409	9	adjunctive	adjunctive	JJ
cord-018764-02l423mk	409	10	therapy	therapy	NN
cord-018764-02l423mk	409	11	for	for	IN
cord-018764-02l423mk	409	12	severe	severe	JJ
cord-018764-02l423mk	409	13	malaria	malaria	NN
cord-018764-02l423mk	409	14	Inhibition	inhibition	NN
cord-018764-02l423mk	409	15	of	of	IN
cord-018764-02l423mk	409	16	endothelial	endothelial	JJ
cord-018764-02l423mk	409	17	activation	activation	NN
cord-018764-02l423mk	409	18	:	:	:
cord-018764-02l423mk	409	19	a	a	DT
cord-018764-02l423mk	409	20	new	new	JJ
cord-018764-02l423mk	409	21	way	way	NN
cord-018764-02l423mk	409	22	to	to	TO
cord-018764-02l423mk	409	23	treat	treat	VB
cord-018764-02l423mk	409	24	cerebral	cerebral	JJ
cord-018764-02l423mk	409	25	malaria	malaria	NN