id	sid	tid	token	lemma	pos
cord-022353-q2k2krnm	1	1	key	key	JJ
cord-022353-q2k2krnm	1	2	:	:	:
cord-022353-q2k2krnm	1	3	cord-022353-q2k2krnm	cord-022353-q2k2krnm	NN
cord-022353-q2k2krnm	1	4	authors	author	NNS
cord-022353-q2k2krnm	1	5	:	:	:
cord-022353-q2k2krnm	1	6	W.	W.	NNP
cord-022353-q2k2krnm	1	7	Quimby	Quimby	NNP
cord-022353-q2k2krnm	1	8	,	,	,
cord-022353-q2k2krnm	1	9	Fred	Fred	NNP
cord-022353-q2k2krnm	1	10	;	;	:
cord-022353-q2k2krnm	1	11	H.	H.	NNP
cord-022353-q2k2krnm	1	12	Luong	Luong	NNP
cord-022353-q2k2krnm	1	13	,	,	,
cord-022353-q2k2krnm	1	14	Richard	Richard	NNP
cord-022353-q2k2krnm	1	15	title	title	NN
cord-022353-q2k2krnm	1	16	:	:	:
cord-022353-q2k2krnm	1	17	Clinical	clinical	JJ
cord-022353-q2k2krnm	1	18	Chemistry	Chemistry	NNP
cord-022353-q2k2krnm	1	19	of	of	IN
cord-022353-q2k2krnm	1	20	the	the	DT
cord-022353-q2k2krnm	1	21	Laboratory	Laboratory	NNP
cord-022353-q2k2krnm	1	22	Mouse	Mouse	NNP
cord-022353-q2k2krnm	1	23	date	date	NN
cord-022353-q2k2krnm	1	24	:	:	:
cord-022353-q2k2krnm	1	25	2007	2007	CD
cord-022353-q2k2krnm	1	26	-	-	SYM
cord-022353-q2k2krnm	1	27	09	09	CD
cord-022353-q2k2krnm	1	28	-	-	HYPH
cord-022353-q2k2krnm	1	29	02	02	CD
cord-022353-q2k2krnm	1	30	journal	journal	NN
cord-022353-q2k2krnm	1	31	:	:	:
cord-022353-q2k2krnm	2	1	The	the	DT
cord-022353-q2k2krnm	2	2	Mouse	Mouse	NNP
cord-022353-q2k2krnm	2	3	in	in	IN
cord-022353-q2k2krnm	2	4	Biomedical	Biomedical	NNP
cord-022353-q2k2krnm	2	5	Research	Research	NNP
cord-022353-q2k2krnm	2	6	DOI	DOI	NNP
cord-022353-q2k2krnm	2	7	:	:	:
cord-022353-q2k2krnm	3	1	10.1016	10.1016	CD
cord-022353-q2k2krnm	3	2	/	/	SYM
cord-022353-q2k2krnm	3	3	b978	b978	NN
cord-022353-q2k2krnm	3	4	-	-	HYPH
cord-022353-q2k2krnm	3	5	012369454	012369454	CD
cord-022353-q2k2krnm	3	6	-	-	HYPH
cord-022353-q2k2krnm	3	7	6/50060	6/50060	CD
cord-022353-q2k2krnm	3	8	-	-	SYM
cord-022353-q2k2krnm	3	9	1	1	CD
cord-022353-q2k2krnm	3	10	sha	sha	NNP
cord-022353-q2k2krnm	3	11	:	:	:
cord-022353-q2k2krnm	4	1	8d15a9c8b9e866d41722a861a600c7b06e126428	8d15a9c8b9e866d41722a861a600c7b06e126428	CD
cord-022353-q2k2krnm	4	2	doc_id	doc_id	CD
cord-022353-q2k2krnm	4	3	:	:	:
cord-022353-q2k2krnm	4	4	22353	22353	CD
cord-022353-q2k2krnm	4	5	cord_uid	cord_uid	NNS
cord-022353-q2k2krnm	4	6	:	:	:
cord-022353-q2k2krnm	4	7	q2k2krnm	q2k2krnm	ADD
cord-022353-q2k2krnm	5	1	The	the	DT
cord-022353-q2k2krnm	5	2	frontier	frontier	NN
cord-022353-q2k2krnm	5	3	of	of	IN
cord-022353-q2k2krnm	5	4	clinical	clinical	JJ
cord-022353-q2k2krnm	5	5	chemistry	chemistry	NN
cord-022353-q2k2krnm	5	6	in	in	IN
cord-022353-q2k2krnm	5	7	the	the	DT
cord-022353-q2k2krnm	5	8	mouse	mouse	NN
cord-022353-q2k2krnm	5	9	has	have	VBZ
cord-022353-q2k2krnm	5	10	advanced	advance	VBN
cord-022353-q2k2krnm	5	11	and	and	CC
cord-022353-q2k2krnm	5	12	expanded	expand	VBN
cord-022353-q2k2krnm	5	13	because	because	IN
cord-022353-q2k2krnm	5	14	of	of	IN
cord-022353-q2k2krnm	5	15	two	two	CD
cord-022353-q2k2krnm	5	16	major	major	JJ
cord-022353-q2k2krnm	5	17	events	event	NNS
cord-022353-q2k2krnm	5	18	such	such	JJ
cord-022353-q2k2krnm	5	19	as	as	IN
cord-022353-q2k2krnm	5	20	,	,	,
cord-022353-q2k2krnm	5	21	the	the	DT
cord-022353-q2k2krnm	5	22	increasing	increase	VBG
cord-022353-q2k2krnm	5	23	reliance	reliance	NN
cord-022353-q2k2krnm	5	24	on	on	IN
cord-022353-q2k2krnm	5	25	mice	mouse	NNS
cord-022353-q2k2krnm	5	26	in	in	IN
cord-022353-q2k2krnm	5	27	biomedical	biomedical	JJ
cord-022353-q2k2krnm	5	28	research	research	NN
cord-022353-q2k2krnm	5	29	,	,	,
cord-022353-q2k2krnm	5	30	and	and	CC
cord-022353-q2k2krnm	5	31	increasing	increase	VBG
cord-022353-q2k2krnm	5	32	availability	availability	NN
cord-022353-q2k2krnm	5	33	of	of	IN
cord-022353-q2k2krnm	5	34	practical	practical	JJ
cord-022353-q2k2krnm	5	35	yet	yet	RB
cord-022353-q2k2krnm	5	36	sophisticated	sophisticated	JJ
cord-022353-q2k2krnm	5	37	techniques	technique	NNS
cord-022353-q2k2krnm	5	38	and	and	CC
cord-022353-q2k2krnm	5	39	instrumentations	instrumentation	NNS
cord-022353-q2k2krnm	5	40	that	that	WDT
cord-022353-q2k2krnm	5	41	have	have	VBP
cord-022353-q2k2krnm	5	42	allowed	allow	VBN
cord-022353-q2k2krnm	5	43	for	for	IN
cord-022353-q2k2krnm	5	44	the	the	DT
cord-022353-q2k2krnm	5	45	detection	detection	NN
cord-022353-q2k2krnm	5	46	of	of	IN
cord-022353-q2k2krnm	5	47	a	a	DT
cord-022353-q2k2krnm	5	48	wider	wide	JJR
cord-022353-q2k2krnm	5	49	variety	variety	NN
cord-022353-q2k2krnm	5	50	of	of	IN
cord-022353-q2k2krnm	5	51	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	5	52	of	of	IN
cord-022353-q2k2krnm	5	53	disease	disease	NN
cord-022353-q2k2krnm	5	54	.	.	.
cord-022353-q2k2krnm	6	1	The	the	DT
cord-022353-q2k2krnm	6	2	progression	progression	NN
cord-022353-q2k2krnm	6	3	of	of	IN
cord-022353-q2k2krnm	6	4	these	these	DT
cord-022353-q2k2krnm	6	5	two	two	CD
cord-022353-q2k2krnm	6	6	events	event	NNS
cord-022353-q2k2krnm	6	7	is	be	VBZ
cord-022353-q2k2krnm	6	8	partially	partially	RB
cord-022353-q2k2krnm	6	9	driven	drive	VBN
cord-022353-q2k2krnm	6	10	by	by	IN
cord-022353-q2k2krnm	6	11	the	the	DT
cord-022353-q2k2krnm	6	12	increasing	increase	VBG
cord-022353-q2k2krnm	6	13	regulatory	regulatory	JJ
cord-022353-q2k2krnm	6	14	demands	demand	NNS
cord-022353-q2k2krnm	6	15	related	relate	VBN
cord-022353-q2k2krnm	6	16	to	to	IN
cord-022353-q2k2krnm	6	17	safety	safety	NN
cord-022353-q2k2krnm	6	18	/	/	SYM
cord-022353-q2k2krnm	6	19	toxicity	toxicity	NN
cord-022353-q2k2krnm	6	20	assessment	assessment	NN
cord-022353-q2k2krnm	6	21	of	of	IN
cord-022353-q2k2krnm	6	22	novel	novel	JJ
cord-022353-q2k2krnm	6	23	drug	drug	NN
cord-022353-q2k2krnm	6	24	development	development	NN
cord-022353-q2k2krnm	6	25	.	.	.
cord-022353-q2k2krnm	7	1	The	the	DT
cord-022353-q2k2krnm	7	2	availability	availability	NN
cord-022353-q2k2krnm	7	3	of	of	IN
cord-022353-q2k2krnm	7	4	inbred	inbred	JJ
cord-022353-q2k2krnm	7	5	strains	strain	NNS
cord-022353-q2k2krnm	7	6	has	have	VBZ
cord-022353-q2k2krnm	7	7	led	lead	VBN
cord-022353-q2k2krnm	7	8	to	to	IN
cord-022353-q2k2krnm	7	9	major	major	JJ
cord-022353-q2k2krnm	7	10	breakthroughs	breakthrough	NNS
cord-022353-q2k2krnm	7	11	in	in	IN
cord-022353-q2k2krnm	7	12	cancer	cancer	NN
cord-022353-q2k2krnm	7	13	,	,	,
cord-022353-q2k2krnm	7	14	biology	biology	NN
cord-022353-q2k2krnm	7	15	,	,	,
cord-022353-q2k2krnm	7	16	and	and	CC
cord-022353-q2k2krnm	7	17	immunology	immunology	NN
cord-022353-q2k2krnm	7	18	.	.	.
cord-022353-q2k2krnm	8	1	In	in	IN
cord-022353-q2k2krnm	8	2	addition	addition	NN
cord-022353-q2k2krnm	8	3	,	,	,
cord-022353-q2k2krnm	8	4	outbred	outbred	JJ
cord-022353-q2k2krnm	8	5	stocks	stock	NNS
cord-022353-q2k2krnm	8	6	continue	continue	VBP
cord-022353-q2k2krnm	8	7	to	to	TO
cord-022353-q2k2krnm	8	8	be	be	VB
cord-022353-q2k2krnm	8	9	utilized	utilize	VBN
cord-022353-q2k2krnm	8	10	in	in	IN
cord-022353-q2k2krnm	8	11	a	a	DT
cord-022353-q2k2krnm	8	12	wide	wide	JJ
cord-022353-q2k2krnm	8	13	variety	variety	NN
cord-022353-q2k2krnm	8	14	of	of	IN
cord-022353-q2k2krnm	8	15	studies	study	NNS
cord-022353-q2k2krnm	8	16	but	but	CC
cord-022353-q2k2krnm	8	17	particularly	particularly	RB
cord-022353-q2k2krnm	8	18	in	in	IN
cord-022353-q2k2krnm	8	19	the	the	DT
cord-022353-q2k2krnm	8	20	fields	field	NNS
cord-022353-q2k2krnm	8	21	of	of	IN
cord-022353-q2k2krnm	8	22	toxicology	toxicology	NN
cord-022353-q2k2krnm	8	23	and	and	CC
cord-022353-q2k2krnm	8	24	pharmacology	pharmacology	NN
cord-022353-q2k2krnm	8	25	.	.	.
cord-022353-q2k2krnm	9	1	The	the	DT
cord-022353-q2k2krnm	9	2	power	power	NN
cord-022353-q2k2krnm	9	3	of	of	IN
cord-022353-q2k2krnm	9	4	these	these	DT
cord-022353-q2k2krnm	9	5	models	model	NNS
cord-022353-q2k2krnm	9	6	to	to	TO
cord-022353-q2k2krnm	9	7	elucidate	elucidate	VB
cord-022353-q2k2krnm	9	8	the	the	DT
cord-022353-q2k2krnm	9	9	genetic	genetic	JJ
cord-022353-q2k2krnm	9	10	basis	basis	NN
cord-022353-q2k2krnm	9	11	of	of	IN
cord-022353-q2k2krnm	9	12	disease	disease	NN
cord-022353-q2k2krnm	9	13	can	can	MD
cord-022353-q2k2krnm	9	14	not	not	RB
cord-022353-q2k2krnm	9	15	be	be	VB
cord-022353-q2k2krnm	9	16	overemphasized	overemphasize	VBN
cord-022353-q2k2krnm	9	17	.	.	.
cord-022353-q2k2krnm	10	1	This	this	DT
cord-022353-q2k2krnm	10	2	provided	provide	VBD
cord-022353-q2k2krnm	10	3	complete	complete	JJ
cord-022353-q2k2krnm	10	4	nucleotide	nucleotide	JJ
cord-022353-q2k2krnm	10	5	sequences	sequence	NNS
cord-022353-q2k2krnm	10	6	for	for	IN
cord-022353-q2k2krnm	10	7	each	each	DT
cord-022353-q2k2krnm	10	8	genome	genome	NN
cord-022353-q2k2krnm	10	9	allowing	allow	VBG
cord-022353-q2k2krnm	10	10	investigators	investigator	NNS
cord-022353-q2k2krnm	10	11	to	to	TO
cord-022353-q2k2krnm	10	12	quickly	quickly	RB
cord-022353-q2k2krnm	10	13	develop	develop	VB
cord-022353-q2k2krnm	10	14	the	the	DT
cord-022353-q2k2krnm	10	15	equivalent	equivalent	JJ
cord-022353-q2k2krnm	10	16	murine	murine	JJ
cord-022353-q2k2krnm	10	17	model	model	NN
cord-022353-q2k2krnm	10	18	for	for	IN
cord-022353-q2k2krnm	10	19	many	many	JJ
cord-022353-q2k2krnm	10	20	of	of	IN
cord-022353-q2k2krnm	10	21	the	the	DT
cord-022353-q2k2krnm	10	22	inherited	inherit	VBN
cord-022353-q2k2krnm	10	23	human	human	JJ
cord-022353-q2k2krnm	10	24	diseases	disease	NNS
cord-022353-q2k2krnm	10	25	.	.	.
cord-022353-q2k2krnm	11	1	Transgenic	transgenic	JJ
cord-022353-q2k2krnm	11	2	and	and	CC
cord-022353-q2k2krnm	11	3	knockout	knockout	NN
cord-022353-q2k2krnm	11	4	mice	mouse	NNS
cord-022353-q2k2krnm	11	5	have	have	VBP
cord-022353-q2k2krnm	11	6	helped	help	VBN
cord-022353-q2k2krnm	11	7	clarify	clarify	VB
cord-022353-q2k2krnm	11	8	disease	disease	NN
cord-022353-q2k2krnm	11	9	pathogenesis	pathogenesis	NN
cord-022353-q2k2krnm	11	10	in	in	IN
cord-022353-q2k2krnm	11	11	virtually	virtually	RB
cord-022353-q2k2krnm	11	12	every	every	DT
cord-022353-q2k2krnm	11	13	area	area	NN
cord-022353-q2k2krnm	11	14	of	of	IN
cord-022353-q2k2krnm	11	15	medicine	medicine	NN
cord-022353-q2k2krnm	11	16	and	and	CC
cord-022353-q2k2krnm	11	17	often	often	RB
cord-022353-q2k2krnm	11	18	elucidated	elucidate	VBD
cord-022353-q2k2krnm	11	19	biochemical	biochemical	JJ
cord-022353-q2k2krnm	11	20	pathways	pathway	NNS
cord-022353-q2k2krnm	11	21	,	,	,
cord-022353-q2k2krnm	11	22	previously	previously	RB
cord-022353-q2k2krnm	11	23	unknown	unknown	JJ
cord-022353-q2k2krnm	11	24	,	,	,
cord-022353-q2k2krnm	11	25	which	which	WDT
cord-022353-q2k2krnm	11	26	are	be	VBP
cord-022353-q2k2krnm	11	27	now	now	RB
cord-022353-q2k2krnm	11	28	subject	subject	JJ
cord-022353-q2k2krnm	11	29	to	to	IN
cord-022353-q2k2krnm	11	30	testing	testing	NN
cord-022353-q2k2krnm	11	31	and	and	CC
cord-022353-q2k2krnm	11	32	quantification	quantification	NN
cord-022353-q2k2krnm	11	33	.	.	.
cord-022353-q2k2krnm	12	1	It	-PRON-	PRP
cord-022353-q2k2krnm	12	2	has	have	VBZ
cord-022353-q2k2krnm	12	3	been	be	VBN
cord-022353-q2k2krnm	12	4	more	more	JJR
cord-022353-q2k2krnm	12	5	than	than	IN
cord-022353-q2k2krnm	12	6	20	20	CD
cord-022353-q2k2krnm	12	7	years	year	NNS
cord-022353-q2k2krnm	12	8	since	since	IN
cord-022353-q2k2krnm	12	9	publication	publication	NN
cord-022353-q2k2krnm	12	10	of	of	IN
cord-022353-q2k2krnm	12	11	the	the	DT
cord-022353-q2k2krnm	12	12	first	first	JJ
cord-022353-q2k2krnm	12	13	edition	edition	NN
cord-022353-q2k2krnm	12	14	of	of	IN
cord-022353-q2k2krnm	12	15	The	the	DT
cord-022353-q2k2krnm	12	16	Mouse	Mouse	NNP
cord-022353-q2k2krnm	12	17	in	in	IN
cord-022353-q2k2krnm	12	18	Biomedical	Biomedical	NNP
cord-022353-q2k2krnm	12	19	Research	Research	NNP
cord-022353-q2k2krnm	12	20	,	,	,
cord-022353-q2k2krnm	12	21	and	and	CC
cord-022353-q2k2krnm	12	22	since	since	IN
cord-022353-q2k2krnm	12	23	that	that	DT
cord-022353-q2k2krnm	12	24	time	time	NN
cord-022353-q2k2krnm	12	25	new	new	JJ
cord-022353-q2k2krnm	12	26	emphasis	emphasis	NN
cord-022353-q2k2krnm	12	27	has	have	VBZ
cord-022353-q2k2krnm	12	28	been	be	VBN
cord-022353-q2k2krnm	12	29	placed	place	VBN
cord-022353-q2k2krnm	12	30	on	on	IN
cord-022353-q2k2krnm	12	31	the	the	DT
cord-022353-q2k2krnm	12	32	mouse	mouse	NN
cord-022353-q2k2krnm	12	33	as	as	IN
cord-022353-q2k2krnm	12	34	a	a	DT
cord-022353-q2k2krnm	12	35	model	model	NN
cord-022353-q2k2krnm	12	36	for	for	IN
cord-022353-q2k2krnm	12	37	the	the	DT
cord-022353-q2k2krnm	12	38	pathophysiology	pathophysiology	NN
cord-022353-q2k2krnm	12	39	and	and	CC
cord-022353-q2k2krnm	12	40	treatment	treatment	NN
cord-022353-q2k2krnm	12	41	of	of	IN
cord-022353-q2k2krnm	12	42	human	human	JJ
cord-022353-q2k2krnm	12	43	diseases	disease	NNS
cord-022353-q2k2krnm	12	44	.	.	.
cord-022353-q2k2krnm	13	1	During	during	IN
cord-022353-q2k2krnm	13	2	this	this	DT
cord-022353-q2k2krnm	13	3	time	time	NN
cord-022353-q2k2krnm	13	4	,	,	,
cord-022353-q2k2krnm	13	5	the	the	DT
cord-022353-q2k2krnm	13	6	frontier	frontier	NN
cord-022353-q2k2krnm	13	7	of	of	IN
cord-022353-q2k2krnm	13	8	clinical	clinical	JJ
cord-022353-q2k2krnm	13	9	chemistry	chemistry	NN
cord-022353-q2k2krnm	13	10	in	in	IN
cord-022353-q2k2krnm	13	11	the	the	DT
cord-022353-q2k2krnm	13	12	mouse	mouse	NN
cord-022353-q2k2krnm	13	13	has	have	VBZ
cord-022353-q2k2krnm	13	14	advanced	advance	VBN
cord-022353-q2k2krnm	13	15	and	and	CC
cord-022353-q2k2krnm	13	16	expanded	expand	VBN
cord-022353-q2k2krnm	13	17	because	because	IN
cord-022353-q2k2krnm	13	18	of	of	IN
cord-022353-q2k2krnm	13	19	two	two	CD
cord-022353-q2k2krnm	13	20	major	major	JJ
cord-022353-q2k2krnm	13	21	events	event	NNS
cord-022353-q2k2krnm	13	22	:	:	:
cord-022353-q2k2krnm	13	23	the	the	DT
cord-022353-q2k2krnm	13	24	increasing	increase	VBG
cord-022353-q2k2krnm	13	25	reliance	reliance	NN
cord-022353-q2k2krnm	13	26	on	on	IN
cord-022353-q2k2krnm	13	27	mice	mouse	NNS
cord-022353-q2k2krnm	13	28	in	in	IN
cord-022353-q2k2krnm	13	29	biomedical	biomedical	JJ
cord-022353-q2k2krnm	13	30	research	research	NN
cord-022353-q2k2krnm	13	31	,	,	,
cord-022353-q2k2krnm	13	32	and	and	CC
cord-022353-q2k2krnm	13	33	increasing	increase	VBG
cord-022353-q2k2krnm	13	34	availability	availability	NN
cord-022353-q2k2krnm	13	35	of	of	IN
cord-022353-q2k2krnm	13	36	practical	practical	JJ
cord-022353-q2k2krnm	13	37	yet	yet	RB
cord-022353-q2k2krnm	13	38	sophisticated	sophisticated	JJ
cord-022353-q2k2krnm	13	39	techniques	technique	NNS
cord-022353-q2k2krnm	13	40	and	and	CC
cord-022353-q2k2krnm	13	41	instrumentations	instrumentation	NNS
cord-022353-q2k2krnm	13	42	that	that	WDT
cord-022353-q2k2krnm	13	43	have	have	VBP
cord-022353-q2k2krnm	13	44	allowed	allow	VBN
cord-022353-q2k2krnm	13	45	for	for	IN
cord-022353-q2k2krnm	13	46	the	the	DT
cord-022353-q2k2krnm	13	47	detection	detection	NN
cord-022353-q2k2krnm	13	48	of	of	IN
cord-022353-q2k2krnm	13	49	a	a	DT
cord-022353-q2k2krnm	13	50	wider	wide	JJR
cord-022353-q2k2krnm	13	51	variety	variety	NN
cord-022353-q2k2krnm	13	52	of	of	IN
cord-022353-q2k2krnm	13	53	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	13	54	of	of	IN
cord-022353-q2k2krnm	13	55	disease	disease	NN
cord-022353-q2k2krnm	13	56	.	.	.
cord-022353-q2k2krnm	14	1	The	the	DT
cord-022353-q2k2krnm	14	2	progression	progression	NN
cord-022353-q2k2krnm	14	3	of	of	IN
cord-022353-q2k2krnm	14	4	these	these	DT
cord-022353-q2k2krnm	14	5	two	two	CD
cord-022353-q2k2krnm	14	6	events	event	NNS
cord-022353-q2k2krnm	14	7	has	have	VBZ
cord-022353-q2k2krnm	14	8	been	be	VBN
cord-022353-q2k2krnm	14	9	partially	partially	RB
cord-022353-q2k2krnm	14	10	driven	drive	VBN
cord-022353-q2k2krnm	14	11	by	by	IN
cord-022353-q2k2krnm	14	12	the	the	DT
cord-022353-q2k2krnm	14	13	increasing	increase	VBG
cord-022353-q2k2krnm	14	14	regulatory	regulatory	JJ
cord-022353-q2k2krnm	14	15	demands	demand	NNS
cord-022353-q2k2krnm	14	16	related	relate	VBN
cord-022353-q2k2krnm	14	17	to	to	IN
cord-022353-q2k2krnm	14	18	safety	safety	NN
cord-022353-q2k2krnm	14	19	/	/	SYM
cord-022353-q2k2krnm	14	20	toxicity	toxicity	NN
cord-022353-q2k2krnm	14	21	assessment	assessment	NN
cord-022353-q2k2krnm	14	22	of	of	IN
cord-022353-q2k2krnm	14	23	novel	novel	JJ
cord-022353-q2k2krnm	14	24	drug	drug	NN
cord-022353-q2k2krnm	14	25	development	development	NN
cord-022353-q2k2krnm	14	26	.	.	.
cord-022353-q2k2krnm	15	1	Abbreviations	abbreviation	NNS
cord-022353-q2k2krnm	15	2	used	use	VBN
cord-022353-q2k2krnm	15	3	in	in	IN
cord-022353-q2k2krnm	15	4	this	this	DT
cord-022353-q2k2krnm	15	5	chapter	chapter	NN
cord-022353-q2k2krnm	15	6	are	be	VBP
cord-022353-q2k2krnm	15	7	summarized	summarize	VBN
cord-022353-q2k2krnm	15	8	in	in	IN
cord-022353-q2k2krnm	15	9	Appendix	Appendix	NNP
cord-022353-q2k2krnm	15	10	6	6	CD
cord-022353-q2k2krnm	15	11	-	-	SYM
cord-022353-q2k2krnm	15	12	1	1	CD
cord-022353-q2k2krnm	15	13	.	.	.
cord-022353-q2k2krnm	16	1	For	for	IN
cord-022353-q2k2krnm	16	2	the	the	DT
cord-022353-q2k2krnm	16	3	last	last	JJ
cord-022353-q2k2krnm	16	4	quarter	quarter	NN
cord-022353-q2k2krnm	16	5	century	century	NN
cord-022353-q2k2krnm	16	6	,	,	,
cord-022353-q2k2krnm	16	7	mice	mouse	NNS
cord-022353-q2k2krnm	16	8	have	have	VBP
cord-022353-q2k2krnm	16	9	been	be	VBN
cord-022353-q2k2krnm	16	10	the	the	DT
cord-022353-q2k2krnm	16	11	most	most	RBS
cord-022353-q2k2krnm	16	12	frequently	frequently	RB
cord-022353-q2k2krnm	16	13	used	use	VBN
cord-022353-q2k2krnm	16	14	mammal	mammal	NN
cord-022353-q2k2krnm	16	15	in	in	IN
cord-022353-q2k2krnm	16	16	biomedical	biomedical	JJ
cord-022353-q2k2krnm	16	17	research	research	NN
cord-022353-q2k2krnm	16	18	,	,	,
cord-022353-q2k2krnm	16	19	rising	rise	VBG
cord-022353-q2k2krnm	16	20	from	from	IN
cord-022353-q2k2krnm	16	21	61	61	CD
cord-022353-q2k2krnm	16	22	%	%	NN
cord-022353-q2k2krnm	16	23	of	of	IN
cord-022353-q2k2krnm	16	24	all	all	DT
cord-022353-q2k2krnm	16	25	mammals	mammal	NNS
cord-022353-q2k2krnm	16	26	used	use	VBN
cord-022353-q2k2krnm	16	27	in	in	IN
cord-022353-q2k2krnm	16	28	1983	1983	CD
cord-022353-q2k2krnm	16	29	to	to	IN
cord-022353-q2k2krnm	16	30	71	71	CD
cord-022353-q2k2krnm	16	31	%	%	NN
cord-022353-q2k2krnm	16	32	in	in	IN
cord-022353-q2k2krnm	16	33	1993	1993	CD
cord-022353-q2k2krnm	17	1	(	(	-LRB-
cord-022353-q2k2krnm	17	2	National	National	NNP
cord-022353-q2k2krnm	17	3	Center	Center	NNP
cord-022353-q2k2krnm	17	4	for	for	IN
cord-022353-q2k2krnm	17	5	Research	Research	NNP
cord-022353-q2k2krnm	17	6	Resources	Resources	NNP
cord-022353-q2k2krnm	17	7	1997	1997	CD
cord-022353-q2k2krnm	17	8	.	.	.
cord-022353-q2k2krnm	18	1	The	the	DT
cord-022353-q2k2krnm	18	2	nature	nature	NN
cord-022353-q2k2krnm	18	3	of	of	IN
cord-022353-q2k2krnm	18	4	their	-PRON-	PRP$
cord-022353-q2k2krnm	18	5	use	use	NN
cord-022353-q2k2krnm	18	6	has	have	VBZ
cord-022353-q2k2krnm	18	7	changed	change	VBN
cord-022353-q2k2krnm	18	8	dramatically	dramatically	RB
cord-022353-q2k2krnm	18	9	during	during	IN
cord-022353-q2k2krnm	18	10	this	this	DT
cord-022353-q2k2krnm	18	11	time	time	NN
cord-022353-q2k2krnm	18	12	.	.	.
cord-022353-q2k2krnm	19	1	During	during	IN
cord-022353-q2k2krnm	19	2	the	the	DT
cord-022353-q2k2krnm	19	3	first	first	JJ
cord-022353-q2k2krnm	19	4	half	half	NN
cord-022353-q2k2krnm	19	5	of	of	IN
cord-022353-q2k2krnm	19	6	the	the	DT
cord-022353-q2k2krnm	19	7	20th	20th	JJ
cord-022353-q2k2krnm	19	8	century	century	NN
cord-022353-q2k2krnm	19	9	,	,	,
cord-022353-q2k2krnm	19	10	a	a	DT
cord-022353-q2k2krnm	19	11	great	great	JJ
cord-022353-q2k2krnm	19	12	deal	deal	NN
cord-022353-q2k2krnm	19	13	of	of	IN
cord-022353-q2k2krnm	19	14	emphasis	emphasis	NN
cord-022353-q2k2krnm	19	15	was	be	VBD
cord-022353-q2k2krnm	19	16	placed	place	VBN
cord-022353-q2k2krnm	19	17	on	on	IN
cord-022353-q2k2krnm	19	18	the	the	DT
cord-022353-q2k2krnm	19	19	development	development	NN
cord-022353-q2k2krnm	19	20	of	of	IN
cord-022353-q2k2krnm	19	21	inbred	inbred	JJ
cord-022353-q2k2krnm	19	22	strains	strain	NNS
cord-022353-q2k2krnm	19	23	.	.	.
cord-022353-q2k2krnm	20	1	The	the	DT
cord-022353-q2k2krnm	20	2	availability	availability	NN
cord-022353-q2k2krnm	20	3	of	of	IN
cord-022353-q2k2krnm	20	4	inbred	inbred	JJ
cord-022353-q2k2krnm	20	5	strains	strain	NNS
cord-022353-q2k2krnm	20	6	has	have	VBZ
cord-022353-q2k2krnm	20	7	led	lead	VBN
cord-022353-q2k2krnm	20	8	to	to	IN
cord-022353-q2k2krnm	20	9	major	major	JJ
cord-022353-q2k2krnm	20	10	breakthroughs	breakthrough	NNS
cord-022353-q2k2krnm	20	11	in	in	IN
cord-022353-q2k2krnm	20	12	cancer	cancer	NN
cord-022353-q2k2krnm	20	13	,	,	,
cord-022353-q2k2krnm	20	14	biology	biology	NN
cord-022353-q2k2krnm	20	15	,	,	,
cord-022353-q2k2krnm	20	16	and	and	CC
cord-022353-q2k2krnm	20	17	immunology	immunology	NN
cord-022353-q2k2krnm	20	18	(	(	-LRB-
cord-022353-q2k2krnm	20	19	Quimby	Quimby	NNP
cord-022353-q2k2krnm	20	20	2002	2002	CD
cord-022353-q2k2krnm	20	21	)	)	-RRB-
cord-022353-q2k2krnm	20	22	.	.	.
cord-022353-q2k2krnm	21	1	By	by	IN
cord-022353-q2k2krnm	21	2	1970	1970	CD
cord-022353-q2k2krnm	21	3	there	there	EX
cord-022353-q2k2krnm	21	4	were	be	VBD
cord-022353-q2k2krnm	21	5	approximately	approximately	RB
cord-022353-q2k2krnm	21	6	250	250	CD
cord-022353-q2k2krnm	21	7	inbred	inbred	JJ
cord-022353-q2k2krnm	21	8	strains	strain	NNS
cord-022353-q2k2krnm	21	9	available	available	JJ
cord-022353-q2k2krnm	21	10	.	.	.
cord-022353-q2k2krnm	22	1	In	in	IN
cord-022353-q2k2krnm	22	2	addition	addition	NN
cord-022353-q2k2krnm	22	3	,	,	,
cord-022353-q2k2krnm	22	4	outbred	outbred	JJ
cord-022353-q2k2krnm	22	5	stocks	stock	NNS
cord-022353-q2k2krnm	22	6	continue	continue	VBP
cord-022353-q2k2krnm	22	7	to	to	TO
cord-022353-q2k2krnm	22	8	be	be	VB
cord-022353-q2k2krnm	22	9	utilized	utilize	VBN
cord-022353-q2k2krnm	22	10	in	in	IN
cord-022353-q2k2krnm	22	11	a	a	DT
cord-022353-q2k2krnm	22	12	wide	wide	JJ
cord-022353-q2k2krnm	22	13	variety	variety	NN
cord-022353-q2k2krnm	22	14	of	of	IN
cord-022353-q2k2krnm	22	15	studies	study	NNS
cord-022353-q2k2krnm	22	16	but	but	CC
cord-022353-q2k2krnm	22	17	particularly	particularly	RB
cord-022353-q2k2krnm	22	18	in	in	IN
cord-022353-q2k2krnm	22	19	the	the	DT
cord-022353-q2k2krnm	22	20	fields	field	NNS
cord-022353-q2k2krnm	22	21	of	of	IN
cord-022353-q2k2krnm	22	22	toxicology	toxicology	NN
cord-022353-q2k2krnm	22	23	and	and	CC
cord-022353-q2k2krnm	22	24	pharmacology	pharmacology	NN
cord-022353-q2k2krnm	22	25	.	.	.
cord-022353-q2k2krnm	23	1	During	during	IN
cord-022353-q2k2krnm	23	2	the	the	DT
cord-022353-q2k2krnm	23	3	second	second	JJ
cord-022353-q2k2krnm	23	4	half	half	NN
cord-022353-q2k2krnm	23	5	of	of	IN
cord-022353-q2k2krnm	23	6	the	the	DT
cord-022353-q2k2krnm	23	7	20th	20th	JJ
cord-022353-q2k2krnm	23	8	century	century	NN
cord-022353-q2k2krnm	23	9	,	,	,
cord-022353-q2k2krnm	23	10	investigators	investigator	NNS
cord-022353-q2k2krnm	23	11	developed	develop	VBD
cord-022353-q2k2krnm	23	12	congenic	congenic	NNP
cord-022353-q2k2krnm	23	13	lines	line	NNS
cord-022353-q2k2krnm	23	14	and	and	CC
cord-022353-q2k2krnm	23	15	recombinant	recombinant	JJ
cord-022353-q2k2krnm	23	16	inbred	inbred	JJ
cord-022353-q2k2krnm	23	17	strains	strain	NNS
cord-022353-q2k2krnm	23	18	,	,	,
cord-022353-q2k2krnm	23	19	each	each	DT
cord-022353-q2k2krnm	23	20	having	have	VBG
cord-022353-q2k2krnm	23	21	an	an	DT
cord-022353-q2k2krnm	23	22	impact	impact	NN
cord-022353-q2k2krnm	23	23	on	on	IN
cord-022353-q2k2krnm	23	24	elucidating	elucidate	VBG
cord-022353-q2k2krnm	23	25	the	the	DT
cord-022353-q2k2krnm	23	26	role	role	NN
cord-022353-q2k2krnm	23	27	of	of	IN
cord-022353-q2k2krnm	23	28	individual	individual	JJ
cord-022353-q2k2krnm	23	29	genes	gene	NNS
cord-022353-q2k2krnm	23	30	and	and	CC
cord-022353-q2k2krnm	23	31	assigning	assign	VBG
cord-022353-q2k2krnm	23	32	new	new	JJ
cord-022353-q2k2krnm	23	33	traits	trait	NNS
cord-022353-q2k2krnm	23	34	to	to	TO
cord-022353-q2k2krnm	23	35	linkage	linkage	VB
cord-022353-q2k2krnm	23	36	groups	group	NNS
cord-022353-q2k2krnm	23	37	respectively	respectively	RB
cord-022353-q2k2krnm	23	38	(	(	-LRB-
cord-022353-q2k2krnm	23	39	Paigen	Paigen	NNP
cord-022353-q2k2krnm	23	40	2003a	2003a	CD
cord-022353-q2k2krnm	23	41	)	)	-RRB-
cord-022353-q2k2krnm	23	42	.	.	.
cord-022353-q2k2krnm	24	1	However	however	RB
cord-022353-q2k2krnm	24	2	,	,	,
cord-022353-q2k2krnm	24	3	beginning	begin	VBG
cord-022353-q2k2krnm	24	4	in	in	IN
cord-022353-q2k2krnm	24	5	the	the	DT
cord-022353-q2k2krnm	24	6	early	early	JJ
cord-022353-q2k2krnm	24	7	1980s	1980	NNS
cord-022353-q2k2krnm	24	8	scientists	scientist	NNS
cord-022353-q2k2krnm	24	9	began	begin	VBD
cord-022353-q2k2krnm	24	10	to	to	IN
cord-022353-q2k2krnm	24	11	genetically	genetically	RB
cord-022353-q2k2krnm	24	12	engineer	engineer	VB
cord-022353-q2k2krnm	24	13	mice	mouse	NNS
cord-022353-q2k2krnm	24	14	by	by	IN
cord-022353-q2k2krnm	24	15	either	either	CC
cord-022353-q2k2krnm	24	16	adding	add	VBG
cord-022353-q2k2krnm	24	17	a	a	DT
cord-022353-q2k2krnm	24	18	new	new	JJ
cord-022353-q2k2krnm	24	19	gene	gene	NN
cord-022353-q2k2krnm	24	20	(	(	-LRB-
cord-022353-q2k2krnm	24	21	transgenic	transgenic	NN
cord-022353-q2k2krnm	24	22	)	)	-RRB-
cord-022353-q2k2krnm	24	23	or	or	CC
cord-022353-q2k2krnm	24	24	deleting	delete	VBG
cord-022353-q2k2krnm	24	25	a	a	DT
cord-022353-q2k2krnm	24	26	normal	normal	JJ
cord-022353-q2k2krnm	24	27	mouse	mouse	NN
cord-022353-q2k2krnm	24	28	gene	gene	NN
cord-022353-q2k2krnm	24	29	(	(	-LRB-
cord-022353-q2k2krnm	24	30	knockout	knockout	NN
cord-022353-q2k2krnm	24	31	,	,	,
cord-022353-q2k2krnm	24	32	KO	KO	NNP
cord-022353-q2k2krnm	24	33	)	)	-RRB-
cord-022353-q2k2krnm	24	34	(	(	-LRB-
cord-022353-q2k2krnm	24	35	Paigen	Paigen	NNP
cord-022353-q2k2krnm	24	36	2003b	2003b	CD
cord-022353-q2k2krnm	24	37	)	)	-RRB-
cord-022353-q2k2krnm	24	38	.	.	.
cord-022353-q2k2krnm	25	1	The	the	DT
cord-022353-q2k2krnm	25	2	power	power	NN
cord-022353-q2k2krnm	25	3	of	of	IN
cord-022353-q2k2krnm	25	4	these	these	DT
cord-022353-q2k2krnm	25	5	models	model	NNS
cord-022353-q2k2krnm	25	6	to	to	TO
cord-022353-q2k2krnm	25	7	elucidate	elucidate	VB
cord-022353-q2k2krnm	25	8	the	the	DT
cord-022353-q2k2krnm	25	9	genetic	genetic	JJ
cord-022353-q2k2krnm	25	10	basis	basis	NN
cord-022353-q2k2krnm	25	11	of	of	IN
cord-022353-q2k2krnm	25	12	disease	disease	NN
cord-022353-q2k2krnm	25	13	can	can	MD
cord-022353-q2k2krnm	25	14	not	not	RB
cord-022353-q2k2krnm	25	15	be	be	VB
cord-022353-q2k2krnm	25	16	overemphasized	overemphasize	VBN
cord-022353-q2k2krnm	25	17	.	.	.
cord-022353-q2k2krnm	26	1	Over	over	IN
cord-022353-q2k2krnm	26	2	the	the	DT
cord-022353-q2k2krnm	26	3	past	past	JJ
cord-022353-q2k2krnm	26	4	15	15	CD
cord-022353-q2k2krnm	26	5	years	year	NNS
cord-022353-q2k2krnm	26	6	,	,	,
cord-022353-q2k2krnm	26	7	publications	publication	NNS
cord-022353-q2k2krnm	26	8	citing	cite	VBG
cord-022353-q2k2krnm	26	9	transgenic	transgenic	JJ
cord-022353-q2k2krnm	26	10	and	and	CC
cord-022353-q2k2krnm	26	11	KO	KO	NNP
cord-022353-q2k2krnm	26	12	mice	mouse	NNS
cord-022353-q2k2krnm	26	13	have	have	VBP
cord-022353-q2k2krnm	26	14	increased	increase	VBN
cord-022353-q2k2krnm	26	15	exponentially	exponentially	RB
cord-022353-q2k2krnm	26	16	and	and	CC
cord-022353-q2k2krnm	26	17	at	at	IN
cord-022353-q2k2krnm	26	18	the	the	DT
cord-022353-q2k2krnm	26	19	time	time	NN
cord-022353-q2k2krnm	26	20	of	of	IN
cord-022353-q2k2krnm	26	21	this	this	DT
cord-022353-q2k2krnm	26	22	writing	writing	NN
cord-022353-q2k2krnm	26	23	the	the	DT
cord-022353-q2k2krnm	26	24	Mutant	Mutant	NNP
cord-022353-q2k2krnm	26	25	Mouse	Mouse	NNP
cord-022353-q2k2krnm	26	26	Resource	Resource	NNP
cord-022353-q2k2krnm	26	27	of	of	IN
cord-022353-q2k2krnm	26	28	the	the	DT
cord-022353-q2k2krnm	26	29	Jackson	Jackson	NNP
cord-022353-q2k2krnm	26	30	Laboratory	Laboratory	NNP
cord-022353-q2k2krnm	26	31	listed	list	VBD
cord-022353-q2k2krnm	26	32	more	more	JJR
cord-022353-q2k2krnm	26	33	than	than	IN
cord-022353-q2k2krnm	26	34	10,000	10,000	CD
cord-022353-q2k2krnm	26	35	such	such	JJ
cord-022353-q2k2krnm	26	36	unique	unique	JJ
cord-022353-q2k2krnm	26	37	lines	line	NNS
cord-022353-q2k2krnm	26	38	.	.	.
cord-022353-q2k2krnm	27	1	During	during	IN
cord-022353-q2k2krnm	27	2	this	this	DT
cord-022353-q2k2krnm	27	3	same	same	JJ
cord-022353-q2k2krnm	27	4	period	period	NN
cord-022353-q2k2krnm	27	5	the	the	DT
cord-022353-q2k2krnm	27	6	results	result	NNS
cord-022353-q2k2krnm	27	7	of	of	IN
cord-022353-q2k2krnm	27	8	both	both	CC
cord-022353-q2k2krnm	27	9	the	the	DT
cord-022353-q2k2krnm	27	10	human	human	NN
cord-022353-q2k2krnm	27	11	and	and	CC
cord-022353-q2k2krnm	27	12	mouse	mouse	NN
cord-022353-q2k2krnm	27	13	genome	genome	NN
cord-022353-q2k2krnm	27	14	projects	project	NNS
cord-022353-q2k2krnm	27	15	were	be	VBD
cord-022353-q2k2krnm	27	16	published	publish	VBN
cord-022353-q2k2krnm	27	17	(	(	-LRB-
cord-022353-q2k2krnm	27	18	International	International	NNP
cord-022353-q2k2krnm	27	19	Human	Human	NNP
cord-022353-q2k2krnm	27	20	Genome	Genome	NNP
cord-022353-q2k2krnm	27	21	Sequencing	Sequencing	NNP
cord-022353-q2k2krnm	27	22	Consortium	Consortium	NNP
cord-022353-q2k2krnm	27	23	2001	2001	CD
cord-022353-q2k2krnm	27	24	;	;	:
cord-022353-q2k2krnm	27	25	Mouse	Mouse	NNP
cord-022353-q2k2krnm	27	26	Genome	Genome	NNP
cord-022353-q2k2krnm	27	27	Sequencing	Sequencing	NNP
cord-022353-q2k2krnm	27	28	Consortium	Consortium	NNP
cord-022353-q2k2krnm	27	29	2002	2002	CD
cord-022353-q2k2krnm	27	30	)	)	-RRB-
cord-022353-q2k2krnm	27	31	.	.	.
cord-022353-q2k2krnm	28	1	This	this	DT
cord-022353-q2k2krnm	28	2	provided	provide	VBD
cord-022353-q2k2krnm	28	3	complete	complete	JJ
cord-022353-q2k2krnm	28	4	nucleotide	nucleotide	JJ
cord-022353-q2k2krnm	28	5	sequences	sequence	NNS
cord-022353-q2k2krnm	28	6	for	for	IN
cord-022353-q2k2krnm	28	7	each	each	DT
cord-022353-q2k2krnm	28	8	genome	genome	NN
cord-022353-q2k2krnm	28	9	allowing	allow	VBG
cord-022353-q2k2krnm	28	10	investigators	investigator	NNS
cord-022353-q2k2krnm	28	11	to	to	TO
cord-022353-q2k2krnm	28	12	quickly	quickly	RB
cord-022353-q2k2krnm	28	13	develop	develop	VB
cord-022353-q2k2krnm	28	14	the	the	DT
cord-022353-q2k2krnm	28	15	equivalent	equivalent	JJ
cord-022353-q2k2krnm	28	16	murine	murine	JJ
cord-022353-q2k2krnm	28	17	model	model	NN
cord-022353-q2k2krnm	28	18	for	for	IN
cord-022353-q2k2krnm	28	19	many	many	JJ
cord-022353-q2k2krnm	28	20	of	of	IN
cord-022353-q2k2krnm	28	21	the	the	DT
cord-022353-q2k2krnm	28	22	inherited	inherit	VBN
cord-022353-q2k2krnm	28	23	human	human	JJ
cord-022353-q2k2krnm	28	24	diseases	disease	NNS
cord-022353-q2k2krnm	28	25	.	.	.
cord-022353-q2k2krnm	29	1	Transgenic	transgenic	JJ
cord-022353-q2k2krnm	29	2	and	and	CC
cord-022353-q2k2krnm	29	3	KO	KO	NNP
cord-022353-q2k2krnm	29	4	mice	mouse	NNS
cord-022353-q2k2krnm	29	5	have	have	VBP
cord-022353-q2k2krnm	29	6	helped	help	VBN
cord-022353-q2k2krnm	29	7	clarify	clarify	VB
cord-022353-q2k2krnm	29	8	disease	disease	NN
cord-022353-q2k2krnm	29	9	pathogenesis	pathogenesis	NN
cord-022353-q2k2krnm	29	10	in	in	IN
cord-022353-q2k2krnm	29	11	virtually	virtually	RB
cord-022353-q2k2krnm	29	12	every	every	DT
cord-022353-q2k2krnm	29	13	area	area	NN
cord-022353-q2k2krnm	29	14	of	of	IN
cord-022353-q2k2krnm	29	15	medicine	medicine	NN
cord-022353-q2k2krnm	29	16	and	and	CC
cord-022353-q2k2krnm	29	17	often	often	RB
cord-022353-q2k2krnm	29	18	elucidated	elucidate	VBD
cord-022353-q2k2krnm	29	19	biochemical	biochemical	JJ
cord-022353-q2k2krnm	29	20	pathways	pathway	NNS
cord-022353-q2k2krnm	29	21	,	,	,
cord-022353-q2k2krnm	29	22	previously	previously	RB
cord-022353-q2k2krnm	29	23	unknown	unknown	JJ
cord-022353-q2k2krnm	29	24	,	,	,
cord-022353-q2k2krnm	29	25	which	which	WDT
cord-022353-q2k2krnm	29	26	are	be	VBP
cord-022353-q2k2krnm	29	27	now	now	RB
cord-022353-q2k2krnm	29	28	subject	subject	JJ
cord-022353-q2k2krnm	29	29	to	to	IN
cord-022353-q2k2krnm	29	30	testing	testing	NN
cord-022353-q2k2krnm	29	31	and	and	CC
cord-022353-q2k2krnm	29	32	quantification	quantification	NN
cord-022353-q2k2krnm	29	33	.	.	.
cord-022353-q2k2krnm	30	1	As	as	IN
cord-022353-q2k2krnm	30	2	a	a	DT
cord-022353-q2k2krnm	30	3	result	result	NN
cord-022353-q2k2krnm	30	4	,	,	,
cord-022353-q2k2krnm	30	5	clinical	clinical	JJ
cord-022353-q2k2krnm	30	6	chemistry	chemistry	NN
cord-022353-q2k2krnm	30	7	in	in	IN
cord-022353-q2k2krnm	30	8	the	the	DT
cord-022353-q2k2krnm	30	9	mouse	mouse	NN
cord-022353-q2k2krnm	30	10	has	have	VBZ
cord-022353-q2k2krnm	30	11	grown	grow	VBN
cord-022353-q2k2krnm	30	12	from	from	IN
cord-022353-q2k2krnm	30	13	evaluation	evaluation	NN
cord-022353-q2k2krnm	30	14	of	of	IN
cord-022353-q2k2krnm	30	15	15	15	CD
cord-022353-q2k2krnm	30	16	-	-	SYM
cord-022353-q2k2krnm	30	17	20	20	CD
cord-022353-q2k2krnm	30	18	analytes	analyte	NNS
cord-022353-q2k2krnm	30	19	found	find	VBN
cord-022353-q2k2krnm	30	20	in	in	IN
cord-022353-q2k2krnm	30	21	plasma	plasma	NN
cord-022353-q2k2krnm	30	22	(	(	-LRB-
cord-022353-q2k2krnm	30	23	or	or	CC
cord-022353-q2k2krnm	30	24	urine	urine	NN
cord-022353-q2k2krnm	30	25	)	)	-RRB-
cord-022353-q2k2krnm	30	26	,	,	,
cord-022353-q2k2krnm	30	27	to	to	IN
cord-022353-q2k2krnm	30	28	hundreds	hundred	NNS
cord-022353-q2k2krnm	30	29	of	of	IN
cord-022353-q2k2krnm	30	30	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	30	31	that	that	WDT
cord-022353-q2k2krnm	30	32	can	can	MD
cord-022353-q2k2krnm	30	33	monitor	monitor	VB
cord-022353-q2k2krnm	30	34	disease	disease	NN
cord-022353-q2k2krnm	30	35	status	status	NN
cord-022353-q2k2krnm	30	36	at	at	IN
cord-022353-q2k2krnm	30	37	the	the	DT
cord-022353-q2k2krnm	30	38	cellular	cellular	JJ
cord-022353-q2k2krnm	30	39	level	level	NN
cord-022353-q2k2krnm	30	40	.	.	.
cord-022353-q2k2krnm	31	1	Due	due	IN
cord-022353-q2k2krnm	31	2	to	to	IN
cord-022353-q2k2krnm	31	3	the	the	DT
cord-022353-q2k2krnm	31	4	massive	massive	JJ
cord-022353-q2k2krnm	31	5	amount	amount	NN
cord-022353-q2k2krnm	31	6	of	of	IN
cord-022353-q2k2krnm	31	7	new	new	JJ
cord-022353-q2k2krnm	31	8	information	information	NN
cord-022353-q2k2krnm	31	9	characterizing	characterize	VBG
cord-022353-q2k2krnm	31	10	each	each	DT
cord-022353-q2k2krnm	31	11	of	of	IN
cord-022353-q2k2krnm	31	12	the	the	DT
cord-022353-q2k2krnm	31	13	standard	standard	JJ
cord-022353-q2k2krnm	31	14	strains	strain	NNS
cord-022353-q2k2krnm	31	15	and	and	CC
cord-022353-q2k2krnm	31	16	mutant	mutant	JJ
cord-022353-q2k2krnm	31	17	lines	line	NNS
cord-022353-q2k2krnm	31	18	of	of	IN
cord-022353-q2k2krnm	31	19	mice	mouse	NNS
cord-022353-q2k2krnm	31	20	,	,	,
cord-022353-q2k2krnm	31	21	a	a	DT
cord-022353-q2k2krnm	31	22	Mouse	Mouse	NNP
cord-022353-q2k2krnm	31	23	Phenome	Phenome	NNP
cord-022353-q2k2krnm	31	24	Database	Database	NNP
cord-022353-q2k2krnm	31	25	has	have	VBZ
cord-022353-q2k2krnm	31	26	been	be	VBN
cord-022353-q2k2krnm	31	27	developed	develop	VBN
cord-022353-q2k2krnm	31	28	to	to	TO
cord-022353-q2k2krnm	31	29	manage	manage	VB
cord-022353-q2k2krnm	31	30	data	datum	NNS
cord-022353-q2k2krnm	31	31	and	and	CC
cord-022353-q2k2krnm	31	32	provide	provide	VB
cord-022353-q2k2krnm	31	33	researchers	researcher	NNS
cord-022353-q2k2krnm	31	34	with	with	IN
cord-022353-q2k2krnm	31	35	the	the	DT
cord-022353-q2k2krnm	31	36	ability	ability	NN
cord-022353-q2k2krnm	31	37	to	to	TO
cord-022353-q2k2krnm	31	38	explore	explore	VB
cord-022353-q2k2krnm	31	39	raw	raw	JJ
cord-022353-q2k2krnm	31	40	phenotypic	phenotypic	JJ
cord-022353-q2k2krnm	31	41	data	datum	NNS
cord-022353-q2k2krnm	31	42	(	(	-LRB-
cord-022353-q2k2krnm	31	43	including	include	VBG
cord-022353-q2k2krnm	31	44	clinical	clinical	JJ
cord-022353-q2k2krnm	31	45	chemistry	chemistry	NN
cord-022353-q2k2krnm	31	46	)	)	-RRB-
cord-022353-q2k2krnm	31	47	and	and	CC
cord-022353-q2k2krnm	31	48	summary	summary	NN
cord-022353-q2k2krnm	31	49	analyses	analysis	NNS
cord-022353-q2k2krnm	31	50	.	.	.
cord-022353-q2k2krnm	32	1	The	the	DT
cord-022353-q2k2krnm	32	2	resource	resource	NN
cord-022353-q2k2krnm	32	3	allows	allow	VBZ
cord-022353-q2k2krnm	32	4	investigators	investigator	NNS
cord-022353-q2k2krnm	32	5	to	to	TO
cord-022353-q2k2krnm	32	6	select	select	VB
cord-022353-q2k2krnm	32	7	the	the	DT
cord-022353-q2k2krnm	32	8	appropriate	appropriate	JJ
cord-022353-q2k2krnm	32	9	murine	murine	JJ
cord-022353-q2k2krnm	32	10	model	model	NN
cord-022353-q2k2krnm	32	11	for	for	IN
cord-022353-q2k2krnm	32	12	physiology	physiology	NN
cord-022353-q2k2krnm	32	13	testing	testing	NN
cord-022353-q2k2krnm	32	14	,	,	,
cord-022353-q2k2krnm	32	15	drug	drug	NN
cord-022353-q2k2krnm	32	16	discovery	discovery	NN
cord-022353-q2k2krnm	32	17	,	,	,
cord-022353-q2k2krnm	32	18	toxicology	toxicology	NN
cord-022353-q2k2krnm	32	19	studies	study	NNS
cord-022353-q2k2krnm	32	20	,	,	,
cord-022353-q2k2krnm	32	21	mutagenesis	mutagenesis	NN
cord-022353-q2k2krnm	32	22	,	,	,
cord-022353-q2k2krnm	32	23	modeling	model	VBG
cord-022353-q2k2krnm	32	24	human	human	JJ
cord-022353-q2k2krnm	32	25	disease	disease	NN
cord-022353-q2k2krnm	32	26	,	,	,
cord-022353-q2k2krnm	32	27	quantitative	quantitative	JJ
cord-022353-q2k2krnm	32	28	trait	trait	NN
cord-022353-q2k2krnm	32	29	loci	locus	NNS
cord-022353-q2k2krnm	32	30	(	(	-LRB-
cord-022353-q2k2krnm	32	31	QTL	QTL	NNP
cord-022353-q2k2krnm	32	32	)	)	-RRB-
cord-022353-q2k2krnm	32	33	analyses	analysis	NNS
cord-022353-q2k2krnm	32	34	,	,	,
cord-022353-q2k2krnm	32	35	identification	identification	NN
cord-022353-q2k2krnm	32	36	of	of	IN
cord-022353-q2k2krnm	32	37	new	new	JJ
cord-022353-q2k2krnm	32	38	genes	gene	NNS
cord-022353-q2k2krnm	32	39	,	,	,
cord-022353-q2k2krnm	32	40	and	and	CC
cord-022353-q2k2krnm	32	41	unraveling	unravel	VBG
cord-022353-q2k2krnm	32	42	the	the	DT
cord-022353-q2k2krnm	32	43	influence	influence	NN
cord-022353-q2k2krnm	32	44	of	of	IN
cord-022353-q2k2krnm	32	45	environment	environment	NN
cord-022353-q2k2krnm	32	46	on	on	IN
cord-022353-q2k2krnm	32	47	genotype	genotype	NN
cord-022353-q2k2krnm	32	48	(	(	-LRB-
cord-022353-q2k2krnm	32	49	Bogue	Bogue	NNP
cord-022353-q2k2krnm	32	50	and	and	CC
cord-022353-q2k2krnm	32	51	Grubb	Grubb	NNP
cord-022353-q2k2krnm	32	52	2004	2004	CD
cord-022353-q2k2krnm	32	53	)	)	-RRB-
cord-022353-q2k2krnm	32	54	.	.	.
cord-022353-q2k2krnm	33	1	By	by	IN
cord-022353-q2k2krnm	33	2	far	far	RB
cord-022353-q2k2krnm	33	3	,	,	,
cord-022353-q2k2krnm	33	4	the	the	DT
cord-022353-q2k2krnm	33	5	most	most	RBS
cord-022353-q2k2krnm	33	6	important	important	JJ
cord-022353-q2k2krnm	33	7	new	new	JJ
cord-022353-q2k2krnm	33	8	technology	technology	NN
cord-022353-q2k2krnm	33	9	in	in	IN
cord-022353-q2k2krnm	33	10	the	the	DT
cord-022353-q2k2krnm	33	11	rapidly	rapidly	RB
cord-022353-q2k2krnm	33	12	growing	grow	VBG
cord-022353-q2k2krnm	33	13	and	and	CC
cord-022353-q2k2krnm	33	14	changing	change	VBG
cord-022353-q2k2krnm	33	15	field	field	NN
cord-022353-q2k2krnm	33	16	of	of	IN
cord-022353-q2k2krnm	33	17	clinical	clinical	JJ
cord-022353-q2k2krnm	33	18	chemistry	chemistry	NN
cord-022353-q2k2krnm	33	19	is	be	VBZ
cord-022353-q2k2krnm	33	20	the	the	DT
cord-022353-q2k2krnm	33	21	discipline	discipline	NN
cord-022353-q2k2krnm	33	22	of	of	IN
cord-022353-q2k2krnm	33	23	proteomics	proteomic	NNS
cord-022353-q2k2krnm	33	24	.	.	.
cord-022353-q2k2krnm	34	1	Proteomics	Proteomics	NNP
cord-022353-q2k2krnm	34	2	combines	combine	VBZ
cord-022353-q2k2krnm	34	3	the	the	DT
cord-022353-q2k2krnm	34	4	disciplines	discipline	NNS
cord-022353-q2k2krnm	34	5	of	of	IN
cord-022353-q2k2krnm	34	6	molecular	molecular	JJ
cord-022353-q2k2krnm	34	7	biology	biology	NN
cord-022353-q2k2krnm	34	8	,	,	,
cord-022353-q2k2krnm	34	9	biochemistry	biochemistry	NN
cord-022353-q2k2krnm	34	10	,	,	,
cord-022353-q2k2krnm	34	11	and	and	CC
cord-022353-q2k2krnm	34	12	genetics	genetic	NNS
cord-022353-q2k2krnm	34	13	to	to	IN
cord-022353-q2k2krnm	34	14	the	the	DT
cord-022353-q2k2krnm	34	15	analysis	analysis	NN
cord-022353-q2k2krnm	34	16	of	of	IN
cord-022353-q2k2krnm	34	17	the	the	DT
cord-022353-q2k2krnm	34	18	structure	structure	NN
cord-022353-q2k2krnm	34	19	,	,	,
cord-022353-q2k2krnm	34	20	function	function	NN
cord-022353-q2k2krnm	34	21	,	,	,
cord-022353-q2k2krnm	34	22	and	and	CC
cord-022353-q2k2krnm	34	23	interactions	interaction	NNS
cord-022353-q2k2krnm	34	24	of	of	IN
cord-022353-q2k2krnm	34	25	proteins	protein	NNS
cord-022353-q2k2krnm	34	26	produced	produce	VBN
cord-022353-q2k2krnm	34	27	by	by	IN
cord-022353-q2k2krnm	34	28	the	the	DT
cord-022353-q2k2krnm	34	29	genes	gene	NNS
cord-022353-q2k2krnm	34	30	of	of	IN
cord-022353-q2k2krnm	34	31	a	a	DT
cord-022353-q2k2krnm	34	32	particular	particular	JJ
cord-022353-q2k2krnm	34	33	cell	cell	NN
cord-022353-q2k2krnm	34	34	,	,	,
cord-022353-q2k2krnm	34	35	tissue	tissue	NN
cord-022353-q2k2krnm	34	36	,	,	,
cord-022353-q2k2krnm	34	37	or	or	CC
cord-022353-q2k2krnm	34	38	organism	organism	NN
cord-022353-q2k2krnm	34	39	.	.	.
cord-022353-q2k2krnm	35	1	The	the	DT
cord-022353-q2k2krnm	35	2	field	field	NN
cord-022353-q2k2krnm	35	3	of	of	IN
cord-022353-q2k2krnm	35	4	proteomics	proteomic	NNS
cord-022353-q2k2krnm	35	5	has	have	VBZ
cord-022353-q2k2krnm	35	6	grown	grow	VBN
cord-022353-q2k2krnm	35	7	mainly	mainly	RB
cord-022353-q2k2krnm	35	8	due	due	JJ
cord-022353-q2k2krnm	35	9	to	to	IN
cord-022353-q2k2krnm	35	10	the	the	DT
cord-022353-q2k2krnm	35	11	development	development	NN
cord-022353-q2k2krnm	35	12	of	of	IN
cord-022353-q2k2krnm	35	13	new	new	JJ
cord-022353-q2k2krnm	35	14	instruments	instrument	NNS
cord-022353-q2k2krnm	35	15	that	that	WDT
cord-022353-q2k2krnm	35	16	are	be	VBP
cord-022353-q2k2krnm	35	17	based	base	VBN
cord-022353-q2k2krnm	35	18	on	on	IN
cord-022353-q2k2krnm	35	19	sophisticated	sophisticated	JJ
cord-022353-q2k2krnm	35	20	techniques	technique	NNS
cord-022353-q2k2krnm	35	21	,	,	,
cord-022353-q2k2krnm	35	22	yet	yet	CC
cord-022353-q2k2krnm	35	23	amenable	amenable	JJ
cord-022353-q2k2krnm	35	24	to	to	IN
cord-022353-q2k2krnm	35	25	practical	practical	JJ
cord-022353-q2k2krnm	35	26	implementation	implementation	NN
cord-022353-q2k2krnm	35	27	.	.	.
cord-022353-q2k2krnm	36	1	For	for	IN
cord-022353-q2k2krnm	36	2	example	example	NN
cord-022353-q2k2krnm	36	3	,	,	,
cord-022353-q2k2krnm	36	4	the	the	DT
cord-022353-q2k2krnm	36	5	development	development	NN
cord-022353-q2k2krnm	36	6	of	of	IN
cord-022353-q2k2krnm	36	7	surface	surface	NN
cord-022353-q2k2krnm	36	8	-	-	HYPH
cord-022353-q2k2krnm	36	9	enhanced	enhance	VBN
cord-022353-q2k2krnm	36	10	laser	laser	NN
cord-022353-q2k2krnm	36	11	desorption	desorption	NN
cord-022353-q2k2krnm	36	12	/	/	SYM
cord-022353-q2k2krnm	36	13	ionization	ionization	NN
cord-022353-q2k2krnm	36	14	(	(	-LRB-
cord-022353-q2k2krnm	36	15	SELDI	SELDI	NNP
cord-022353-q2k2krnm	36	16	)	)	-RRB-
cord-022353-q2k2krnm	36	17	platform	platform	NN
cord-022353-q2k2krnm	36	18	time	time	NN
cord-022353-q2k2krnm	36	19	-	-	HYPH
cord-022353-q2k2krnm	36	20	of	of	IN
cord-022353-q2k2krnm	36	21	-	-	HYPH
cord-022353-q2k2krnm	36	22	flight	flight	NN
cord-022353-q2k2krnm	36	23	(	(	-LRB-
cord-022353-q2k2krnm	36	24	TOF	TOF	NNP
cord-022353-q2k2krnm	36	25	)	)	-RRB-
cord-022353-q2k2krnm	36	26	mass	mass	NN
cord-022353-q2k2krnm	36	27	spectroscopy	spectroscopy	NN
cord-022353-q2k2krnm	36	28	(	(	-LRB-
cord-022353-q2k2krnm	36	29	MS	MS	NNP
cord-022353-q2k2krnm	36	30	)	)	-RRB-
cord-022353-q2k2krnm	36	31	allowed	allow	VBD
cord-022353-q2k2krnm	36	32	Petricoin	Petricoin	NNP
cord-022353-q2k2krnm	36	33	et	et	FW
cord-022353-q2k2krnm	36	34	al	al	NNP
cord-022353-q2k2krnm	36	35	.	.	.
cord-022353-q2k2krnm	37	1	(	(	-LRB-
cord-022353-q2k2krnm	37	2	2002a	2002a	CD
cord-022353-q2k2krnm	37	3	)	)	-RRB-
cord-022353-q2k2krnm	37	4	to	to	TO
cord-022353-q2k2krnm	37	5	identify	identify	VB
cord-022353-q2k2krnm	37	6	five	five	CD
cord-022353-q2k2krnm	37	7	peptides	peptide	NNS
cord-022353-q2k2krnm	37	8	in	in	IN
cord-022353-q2k2krnm	37	9	the	the	DT
cord-022353-q2k2krnm	37	10	sera	sera	NNP
cord-022353-q2k2krnm	37	11	of	of	IN
cord-022353-q2k2krnm	37	12	women	woman	NNS
cord-022353-q2k2krnm	37	13	with	with	IN
cord-022353-q2k2krnm	37	14	ovarian	ovarian	JJ
cord-022353-q2k2krnm	37	15	cancer	cancer	NN
cord-022353-q2k2krnm	37	16	that	that	WDT
cord-022353-q2k2krnm	37	17	were	be	VBD
cord-022353-q2k2krnm	37	18	not	not	RB
cord-022353-q2k2krnm	37	19	found	find	VBN
cord-022353-q2k2krnm	37	20	in	in	IN
cord-022353-q2k2krnm	37	21	women	woman	NNS
cord-022353-q2k2krnm	37	22	without	without	IN
cord-022353-q2k2krnm	37	23	ovarian	ovarian	JJ
cord-022353-q2k2krnm	37	24	cancer	cancer	NN
cord-022353-q2k2krnm	37	25	,	,	,
cord-022353-q2k2krnm	37	26	even	even	RB
cord-022353-q2k2krnm	37	27	though	though	IN
cord-022353-q2k2krnm	37	28	the	the	DT
cord-022353-q2k2krnm	37	29	structure	structure	NN
cord-022353-q2k2krnm	37	30	and	and	CC
cord-022353-q2k2krnm	37	31	function	function	NN
cord-022353-q2k2krnm	37	32	of	of	IN
cord-022353-q2k2krnm	37	33	some	some	DT
cord-022353-q2k2krnm	37	34	of	of	IN
cord-022353-q2k2krnm	37	35	these	these	DT
cord-022353-q2k2krnm	37	36	peptides	peptide	NNS
cord-022353-q2k2krnm	37	37	were	be	VBD
cord-022353-q2k2krnm	37	38	not	not	RB
cord-022353-q2k2krnm	37	39	actually	actually	RB
cord-022353-q2k2krnm	37	40	known	know	VBN
cord-022353-q2k2krnm	37	41	.	.	.
cord-022353-q2k2krnm	38	1	Building	build	VBG
cord-022353-q2k2krnm	38	2	on	on	IN
cord-022353-q2k2krnm	38	3	these	these	DT
cord-022353-q2k2krnm	38	4	findings	finding	NNS
cord-022353-q2k2krnm	38	5	,	,	,
cord-022353-q2k2krnm	38	6	Zhang	Zhang	NNP
cord-022353-q2k2krnm	38	7	et	et	NNP
cord-022353-q2k2krnm	38	8	al	al	NNP
cord-022353-q2k2krnm	38	9	.	.	.
cord-022353-q2k2krnm	39	1	(	(	-LRB-
cord-022353-q2k2krnm	39	2	2004	2004	CD
cord-022353-q2k2krnm	39	3	)	)	-RRB-
cord-022353-q2k2krnm	39	4	combined	combine	VBD
cord-022353-q2k2krnm	39	5	the	the	DT
cord-022353-q2k2krnm	39	6	SELDI	SELDI	NNP
cord-022353-q2k2krnm	39	7	-	-	HYPH
cord-022353-q2k2krnm	39	8	TOF	TOF	NNP
cord-022353-q2k2krnm	39	9	MS	MS	NNP
cord-022353-q2k2krnm	39	10	with	with	IN
cord-022353-q2k2krnm	39	11	protein	protein	NN
cord-022353-q2k2krnm	39	12	separation	separation	NN
cord-022353-q2k2krnm	39	13	procedures	procedure	NNS
cord-022353-q2k2krnm	39	14	to	to	TO
cord-022353-q2k2krnm	39	15	develop	develop	VB
cord-022353-q2k2krnm	39	16	a	a	DT
cord-022353-q2k2krnm	39	17	multianalyte	multianalyte	JJ
cord-022353-q2k2krnm	39	18	immunoassay	immunoassay	NN
cord-022353-q2k2krnm	39	19	for	for	IN
cord-022353-q2k2krnm	39	20	rapidly	rapidly	RB
cord-022353-q2k2krnm	39	21	screening	screen	VBG
cord-022353-q2k2krnm	39	22	potential	potential	JJ
cord-022353-q2k2krnm	39	23	cancer	cancer	NN
cord-022353-q2k2krnm	39	24	patients	patient	NNS
cord-022353-q2k2krnm	39	25	.	.	.
cord-022353-q2k2krnm	40	1	This	this	DT
cord-022353-q2k2krnm	40	2	process	process	NN
cord-022353-q2k2krnm	40	3	of	of	IN
cord-022353-q2k2krnm	40	4	identifying	identify	VBG
cord-022353-q2k2krnm	40	5	proteins	protein	NNS
cord-022353-q2k2krnm	40	6	(	(	-LRB-
cord-022353-q2k2krnm	40	7	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	40	8	)	)	-RRB-
cord-022353-q2k2krnm	40	9	that	that	WDT
cord-022353-q2k2krnm	40	10	are	be	VBP
cord-022353-q2k2krnm	40	11	predictive	predictive	JJ
cord-022353-q2k2krnm	40	12	for	for	IN
cord-022353-q2k2krnm	40	13	a	a	DT
cord-022353-q2k2krnm	40	14	disease	disease	NN
cord-022353-q2k2krnm	40	15	is	be	VBZ
cord-022353-q2k2krnm	40	16	known	know	VBN
cord-022353-q2k2krnm	40	17	as	as	IN
cord-022353-q2k2krnm	40	18	plasma	plasma	NN
cord-022353-q2k2krnm	40	19	protein	protein	NN
cord-022353-q2k2krnm	40	20	profiling	profiling	NN
cord-022353-q2k2krnm	40	21	.	.	.
cord-022353-q2k2krnm	41	1	Similar	similar	JJ
cord-022353-q2k2krnm	41	2	technology	technology	NN
cord-022353-q2k2krnm	41	3	has	have	VBZ
cord-022353-q2k2krnm	41	4	been	be	VBN
cord-022353-q2k2krnm	41	5	used	use	VBN
cord-022353-q2k2krnm	41	6	to	to	TO
cord-022353-q2k2krnm	41	7	develop	develop	VB
cord-022353-q2k2krnm	41	8	plasma	plasma	NN
cord-022353-q2k2krnm	41	9	protein	protein	NN
cord-022353-q2k2krnm	41	10	profiles	profile	NNS
cord-022353-q2k2krnm	41	11	for	for	IN
cord-022353-q2k2krnm	41	12	neoplastic	neoplastic	JJ
cord-022353-q2k2krnm	41	13	conditions	condition	NNS
cord-022353-q2k2krnm	41	14	in	in	IN
cord-022353-q2k2krnm	41	15	humans	human	NNS
cord-022353-q2k2krnm	41	16	,	,	,
cord-022353-q2k2krnm	41	17	such	such	JJ
cord-022353-q2k2krnm	41	18	as	as	IN
cord-022353-q2k2krnm	41	19	prostate	prostate	NN
cord-022353-q2k2krnm	41	20	cancer	cancer	NN
cord-022353-q2k2krnm	41	21	Petricoin	Petricoin	NNP
cord-022353-q2k2krnm	41	22	et	et	NNP
cord-022353-q2k2krnm	41	23	al	al	NNP
cord-022353-q2k2krnm	41	24	.	.	.
cord-022353-q2k2krnm	42	1	2002b	2002b	CD
cord-022353-q2k2krnm	43	1	;	;	:
cord-022353-q2k2krnm	43	2	Qu	Qu	NNP
cord-022353-q2k2krnm	43	3	et	et	NNP
cord-022353-q2k2krnm	43	4	al	al	NNP
cord-022353-q2k2krnm	43	5	.	.	.
cord-022353-q2k2krnm	43	6	2002	2002	CD
cord-022353-q2k2krnm	43	7	)	)	-RRB-
cord-022353-q2k2krnm	43	8	and	and	CC
cord-022353-q2k2krnm	43	9	bladder	bladder	NN
cord-022353-q2k2krnm	43	10	cancer	cancer	NN
cord-022353-q2k2krnm	44	1	(	(	-LRB-
cord-022353-q2k2krnm	44	2	Adam	Adam	NNP
cord-022353-q2k2krnm	44	3	et	et	NNP
cord-022353-q2k2krnm	44	4	al	al	NNP
cord-022353-q2k2krnm	44	5	.	.	.
cord-022353-q2k2krnm	45	1	2001	2001	CD
cord-022353-q2k2krnm	45	2	;	;	:
cord-022353-q2k2krnm	45	3	Vlahou	Vlahou	NNP
cord-022353-q2k2krnm	45	4	et	et	NNP
cord-022353-q2k2krnm	45	5	al	al	NNP
cord-022353-q2k2krnm	45	6	.	.	NNP
cord-022353-q2k2krnm	45	7	2001	2001	CD
cord-022353-q2k2krnm	45	8	)	)	-RRB-
cord-022353-q2k2krnm	45	9	,	,	,
cord-022353-q2k2krnm	45	10	as	as	RB
cord-022353-q2k2krnm	45	11	well	well	RB
cord-022353-q2k2krnm	45	12	as	as	IN
cord-022353-q2k2krnm	45	13	a	a	DT
cord-022353-q2k2krnm	45	14	variety	variety	NN
cord-022353-q2k2krnm	45	15	of	of	IN
cord-022353-q2k2krnm	45	16	non	non	JJ
cord-022353-q2k2krnm	45	17	-	-	JJ
cord-022353-q2k2krnm	45	18	neoplastic	neoplastic	JJ
cord-022353-q2k2krnm	45	19	conditions	condition	NNS
cord-022353-q2k2krnm	45	20	,	,	,
cord-022353-q2k2krnm	45	21	such	such	JJ
cord-022353-q2k2krnm	45	22	as	as	IN
cord-022353-q2k2krnm	45	23	ischemic	ischemic	JJ
cord-022353-q2k2krnm	45	24	versus	versus	IN
cord-022353-q2k2krnm	45	25	hemorrhagic	hemorrhagic	JJ
cord-022353-q2k2krnm	45	26	stroke	stroke	NN
cord-022353-q2k2krnm	45	27	,	,	,
cord-022353-q2k2krnm	45	28	severe	severe	JJ
cord-022353-q2k2krnm	45	29	acute	acute	JJ
cord-022353-q2k2krnm	45	30	respiratory	respiratory	JJ
cord-022353-q2k2krnm	45	31	syndrome	syndrome	NN
cord-022353-q2k2krnm	46	1	(	(	-LRB-
cord-022353-q2k2krnm	46	2	Kang	Kang	NNP
cord-022353-q2k2krnm	46	3	et	et	NNP
cord-022353-q2k2krnm	46	4	al	al	NNP
cord-022353-q2k2krnm	46	5	.	.	NNP
cord-022353-q2k2krnm	46	6	2005	2005	CD
cord-022353-q2k2krnm	46	7	)	)	-RRB-
cord-022353-q2k2krnm	46	8	,	,	,
cord-022353-q2k2krnm	46	9	Alzheimer	Alzheimer	NNP
cord-022353-q2k2krnm	46	10	's	's	POS
cord-022353-q2k2krnm	46	11	disease	disease	NN
cord-022353-q2k2krnm	47	1	(	(	-LRB-
cord-022353-q2k2krnm	47	2	Carrette	Carrette	NNP
cord-022353-q2k2krnm	47	3	et	et	NNP
cord-022353-q2k2krnm	47	4	al	al	NNP
cord-022353-q2k2krnm	47	5	.	.	NNP
cord-022353-q2k2krnm	47	6	2003	2003	CD
cord-022353-q2k2krnm	47	7	)	)	-RRB-
cord-022353-q2k2krnm	47	8	,	,	,
cord-022353-q2k2krnm	47	9	and	and	CC
cord-022353-q2k2krnm	47	10	Creutzfeldt	Creutzfeldt	NNP
cord-022353-q2k2krnm	47	11	-	-	HYPH
cord-022353-q2k2krnm	47	12	Jakob	Jakob	NNP
cord-022353-q2k2krnm	47	13	disease	disease	NN
cord-022353-q2k2krnm	48	1	(	(	-LRB-
cord-022353-q2k2krnm	48	2	Sanchez	Sanchez	NNP
cord-022353-q2k2krnm	48	3	et	et	NNP
cord-022353-q2k2krnm	48	4	al	al	NNP
cord-022353-q2k2krnm	48	5	.	.	.
cord-022353-q2k2krnm	48	6	2004	2004	CD
cord-022353-q2k2krnm	48	7	)	)	-RRB-
cord-022353-q2k2krnm	48	8	.	.	.
cord-022353-q2k2krnm	49	1	Plasma	plasma	NN
cord-022353-q2k2krnm	49	2	protein	protein	NN
cord-022353-q2k2krnm	49	3	profiling	profiling	NN
cord-022353-q2k2krnm	49	4	has	have	VBZ
cord-022353-q2k2krnm	49	5	also	also	RB
cord-022353-q2k2krnm	49	6	begun	begin	VBN
cord-022353-q2k2krnm	49	7	in	in	IN
cord-022353-q2k2krnm	49	8	mouse	mouse	NN
cord-022353-q2k2krnm	49	9	models	model	NNS
cord-022353-q2k2krnm	49	10	.	.	.
cord-022353-q2k2krnm	50	1	Xiang	Xiang	NNP
cord-022353-q2k2krnm	50	2	et	et	NNP
cord-022353-q2k2krnm	50	3	al	al	NNP
cord-022353-q2k2krnm	50	4	.	.	.
cord-022353-q2k2krnm	51	1	(	(	-LRB-
cord-022353-q2k2krnm	51	2	2004	2004	CD
cord-022353-q2k2krnm	51	3	)	)	-RRB-
cord-022353-q2k2krnm	51	4	used	use	VBD
cord-022353-q2k2krnm	51	5	a	a	DT
cord-022353-q2k2krnm	51	6	combination	combination	NN
cord-022353-q2k2krnm	51	7	of	of	IN
cord-022353-q2k2krnm	51	8	two	two	CD
cord-022353-q2k2krnm	51	9	-	-	HYPH
cord-022353-q2k2krnm	51	10	dimensional	dimensional	JJ
cord-022353-q2k2krnm	51	11	gel	gel	NN
cord-022353-q2k2krnm	51	12	electrophoresis	electrophoresis	NN
cord-022353-q2k2krnm	51	13	(	(	-LRB-
cord-022353-q2k2krnm	51	14	2D	2D	NNP
cord-022353-q2k2krnm	51	15	-	-	HYPH
cord-022353-q2k2krnm	51	16	GE	GE	NNP
cord-022353-q2k2krnm	51	17	)	)	-RRB-
cord-022353-q2k2krnm	51	18	and	and	CC
cord-022353-q2k2krnm	51	19	matrix	matrix	NN
cord-022353-q2k2krnm	51	20	-	-	HYPH
cord-022353-q2k2krnm	51	21	assisted	assist	VBN
cord-022353-q2k2krnm	51	22	laser	laser	NN
cord-022353-q2k2krnm	51	23	desorption	desorption	NN
cord-022353-q2k2krnm	51	24	/	/	SYM
cord-022353-q2k2krnm	51	25	ionization	ionization	NN
cord-022353-q2k2krnm	51	26	(	(	-LRB-
cord-022353-q2k2krnm	51	27	MALDI	MALDI	NNP
cord-022353-q2k2krnm	51	28	)	)	-RRB-
cord-022353-q2k2krnm	51	29	TOF	TOF	NNP
cord-022353-q2k2krnm	51	30	MS	MS	NNP
cord-022353-q2k2krnm	51	31	to	to	TO
cord-022353-q2k2krnm	51	32	quantify	quantify	VB
cord-022353-q2k2krnm	51	33	serum	serum	NN
cord-022353-q2k2krnm	51	34	protein	protein	NN
cord-022353-q2k2krnm	51	35	profiles	profile	NNS
cord-022353-q2k2krnm	51	36	of	of	IN
cord-022353-q2k2krnm	51	37	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	51	38	mice	mouse	NNS
cord-022353-q2k2krnm	51	39	harboring	harbor	VBG
cord-022353-q2k2krnm	51	40	the	the	DT
cord-022353-q2k2krnm	51	41	Lewis	Lewis	NNP
cord-022353-q2k2krnm	51	42	carcinoma	carcinoma	NN
cord-022353-q2k2krnm	51	43	with	with	IN
cord-022353-q2k2krnm	51	44	and	and	CC
cord-022353-q2k2krnm	51	45	without	without	IN
cord-022353-q2k2krnm	51	46	treatment	treatment	NN
cord-022353-q2k2krnm	51	47	using	use	VBG
cord-022353-q2k2krnm	51	48	acetazolamide	acetazolamide	NN
cord-022353-q2k2krnm	51	49	.	.	.
cord-022353-q2k2krnm	52	1	They	-PRON-	PRP
cord-022353-q2k2krnm	52	2	found	find	VBD
cord-022353-q2k2krnm	52	3	upregulation	upregulation	NN
cord-022353-q2k2krnm	52	4	of	of	IN
cord-022353-q2k2krnm	52	5	many	many	JJ
cord-022353-q2k2krnm	52	6	peptides	peptide	NNS
cord-022353-q2k2krnm	52	7	associated	associate	VBN
cord-022353-q2k2krnm	52	8	with	with	IN
cord-022353-q2k2krnm	52	9	tumor	tumor	NN
cord-022353-q2k2krnm	52	10	growth	growth	NN
cord-022353-q2k2krnm	52	11	and	and	CC
cord-022353-q2k2krnm	52	12	metastasis	metastasis	NN
cord-022353-q2k2krnm	52	13	,	,	,
cord-022353-q2k2krnm	52	14	and	and	CC
cord-022353-q2k2krnm	52	15	many	many	JJ
cord-022353-q2k2krnm	52	16	of	of	IN
cord-022353-q2k2krnm	52	17	these	these	DT
cord-022353-q2k2krnm	52	18	same	same	JJ
cord-022353-q2k2krnm	52	19	peptides	peptide	NNS
cord-022353-q2k2krnm	52	20	were	be	VBD
cord-022353-q2k2krnm	52	21	modified	modify	VBN
cord-022353-q2k2krnm	52	22	during	during	IN
cord-022353-q2k2krnm	52	23	treatment	treatment	NN
cord-022353-q2k2krnm	52	24	.	.	.
cord-022353-q2k2krnm	53	1	Two	two	CD
cord-022353-q2k2krnm	53	2	specific	specific	JJ
cord-022353-q2k2krnm	53	3	targets	target	NNS
cord-022353-q2k2krnm	53	4	of	of	IN
cord-022353-q2k2krnm	53	5	acetazolamide	acetazolamide	NN
cord-022353-q2k2krnm	53	6	antitumor	antitumor	JJ
cord-022353-q2k2krnm	53	7	activity	activity	NN
cord-022353-q2k2krnm	53	8	were	be	VBD
cord-022353-q2k2krnm	53	9	subsequently	subsequently	RB
cord-022353-q2k2krnm	53	10	identified	identify	VBN
cord-022353-q2k2krnm	53	11	as	as	IN
cord-022353-q2k2krnm	53	12	histone	histone	NN
cord-022353-q2k2krnm	53	13	H2B	H2B	NNP
cord-022353-q2k2krnm	53	14	and	and	CC
cord-022353-q2k2krnm	53	15	CROCI	CROCI	NNP
cord-022353-q2k2krnm	53	16	(	(	-LRB-
cord-022353-q2k2krnm	53	17	a	a	DT
cord-022353-q2k2krnm	53	18	UBC	UBC	NNP
cord-022353-q2k2krnm	53	19	-	-	HYPH
cord-022353-q2k2krnm	53	20	like	like	JJ
cord-022353-q2k2krnm	53	21	peptide	peptide	NN
cord-022353-q2k2krnm	53	22	)	)	-RRB-
cord-022353-q2k2krnm	53	23	.	.	.
cord-022353-q2k2krnm	54	1	Park	Park	NNP
cord-022353-q2k2krnm	54	2	et	et	FW
cord-022353-q2k2krnm	54	3	al	al	NNP
cord-022353-q2k2krnm	54	4	.	.	.
cord-022353-q2k2krnm	55	1	(	(	-LRB-
cord-022353-q2k2krnm	55	2	2004	2004	CD
cord-022353-q2k2krnm	55	3	)	)	-RRB-
cord-022353-q2k2krnm	55	4	used	use	VBD
cord-022353-q2k2krnm	55	5	similar	similar	JJ
cord-022353-q2k2krnm	55	6	technology	technology	NN
cord-022353-q2k2krnm	55	7	to	to	TO
cord-022353-q2k2krnm	55	8	determine	determine	VB
cord-022353-q2k2krnm	55	9	plasma	plasma	NN
cord-022353-q2k2krnm	55	10	protein	protein	NN
cord-022353-q2k2krnm	55	11	profiles	profile	NNS
cord-022353-q2k2krnm	55	12	for	for	IN
cord-022353-q2k2krnm	55	13	high	high	JJ
cord-022353-q2k2krnm	55	14	(	(	-LRB-
cord-022353-q2k2krnm	55	15	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	55	16	)	)	-RRB-
cord-022353-q2k2krnm	55	17	and	and	CC
cord-022353-q2k2krnm	55	18	low	low	JJ
cord-022353-q2k2krnm	55	19	(	(	-LRB-
cord-022353-q2k2krnm	55	20	C3H	c3h	RB
cord-022353-q2k2krnm	55	21	)	)	-RRB-
cord-022353-q2k2krnm	55	22	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	55	23	prone	prone	JJ
cord-022353-q2k2krnm	55	24	strains	strain	NNS
cord-022353-q2k2krnm	55	25	of	of	IN
cord-022353-q2k2krnm	55	26	mice	mouse	NNS
cord-022353-q2k2krnm	55	27	on	on	IN
cord-022353-q2k2krnm	55	28	normal	normal	JJ
cord-022353-q2k2krnm	55	29	or	or	CC
cord-022353-q2k2krnm	55	30	atherogenic	atherogenic	JJ
cord-022353-q2k2krnm	55	31	diets	diet	NNS
cord-022353-q2k2krnm	55	32	.	.	.
cord-022353-q2k2krnm	56	1	They	-PRON-	PRP
cord-022353-q2k2krnm	56	2	identified	identify	VBD
cord-022353-q2k2krnm	56	3	30	30	CD
cord-022353-q2k2krnm	56	4	proteins	protein	NNS
cord-022353-q2k2krnm	56	5	in	in	IN
cord-022353-q2k2krnm	56	6	which	which	WDT
cord-022353-q2k2krnm	56	7	the	the	DT
cord-022353-q2k2krnm	56	8	levels	level	NNS
cord-022353-q2k2krnm	56	9	had	have	VBD
cord-022353-q2k2krnm	56	10	changed	change	VBN
cord-022353-q2k2krnm	56	11	after	after	IN
cord-022353-q2k2krnm	56	12	eating	eat	VBG
cord-022353-q2k2krnm	56	13	an	an	DT
cord-022353-q2k2krnm	56	14	atherogenic	atherogenic	JJ
cord-022353-q2k2krnm	56	15	diet	diet	NN
cord-022353-q2k2krnm	56	16	.	.	.
cord-022353-q2k2krnm	57	1	Of	of	IN
cord-022353-q2k2krnm	57	2	these	these	DT
cord-022353-q2k2krnm	57	3	,	,	,
cord-022353-q2k2krnm	57	4	14	14	CD
cord-022353-q2k2krnm	57	5	were	be	VBD
cord-022353-q2k2krnm	57	6	differentially	differentially	RB
cord-022353-q2k2krnm	57	7	changed	change	VBN
cord-022353-q2k2krnm	57	8	in	in	IN
cord-022353-q2k2krnm	57	9	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	57	10	mice	mouse	NNS
cord-022353-q2k2krnm	57	11	and	and	CC
cord-022353-q2k2krnm	57	12	an	an	DT
cord-022353-q2k2krnm	57	13	additional	additional	JJ
cord-022353-q2k2krnm	57	14	16	16	CD
cord-022353-q2k2krnm	57	15	were	be	VBD
cord-022353-q2k2krnm	57	16	changed	change	VBN
cord-022353-q2k2krnm	57	17	in	in	IN
cord-022353-q2k2krnm	57	18	both	both	DT
cord-022353-q2k2krnm	57	19	strains	strain	NNS
cord-022353-q2k2krnm	57	20	.	.	.
cord-022353-q2k2krnm	58	1	In	in	IN
cord-022353-q2k2krnm	58	2	addition	addition	NN
cord-022353-q2k2krnm	58	3	,	,	,
cord-022353-q2k2krnm	58	4	28	28	CD
cord-022353-q2k2krnm	58	5	proteins	protein	NNS
cord-022353-q2k2krnm	58	6	were	be	VBD
cord-022353-q2k2krnm	58	7	differentially	differentially	RB
cord-022353-q2k2krnm	58	8	expressed	express	VBN
cord-022353-q2k2krnm	58	9	between	between	IN
cord-022353-q2k2krnm	58	10	the	the	DT
cord-022353-q2k2krnm	58	11	two	two	CD
cord-022353-q2k2krnm	58	12	strains	strain	NNS
cord-022353-q2k2krnm	58	13	regardless	regardless	RB
cord-022353-q2k2krnm	58	14	of	of	IN
cord-022353-q2k2krnm	58	15	diets	diet	NNS
cord-022353-q2k2krnm	58	16	.	.	.
cord-022353-q2k2krnm	59	1	Four	four	CD
cord-022353-q2k2krnm	59	2	of	of	IN
cord-022353-q2k2krnm	59	3	these	these	DT
cord-022353-q2k2krnm	59	4	proteins	protein	NNS
cord-022353-q2k2krnm	59	5	were	be	VBD
cord-022353-q2k2krnm	59	6	upregulated	upregulate	VBN
cord-022353-q2k2krnm	59	7	in	in	IN
cord-022353-q2k2krnm	59	8	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	59	9	and	and	CC
cord-022353-q2k2krnm	59	10	11	11	CD
cord-022353-q2k2krnm	59	11	were	be	VBD
cord-022353-q2k2krnm	59	12	upregulated	upregulate	VBN
cord-022353-q2k2krnm	59	13	in	in	IN
cord-022353-q2k2krnm	59	14	C3H.	C3H.	NNP
cord-022353-q2k2krnm	59	15	Nine	Nine	NNP
cord-022353-q2k2krnm	59	16	of	of	IN
cord-022353-q2k2krnm	59	17	those	those	DT
cord-022353-q2k2krnm	59	18	protein	protein	NN
cord-022353-q2k2krnm	59	19	markers	marker	NNS
cord-022353-q2k2krnm	59	20	were	be	VBD
cord-022353-q2k2krnm	59	21	definitively	definitively	RB
cord-022353-q2k2krnm	59	22	identified	identify	VBN
cord-022353-q2k2krnm	59	23	and	and	CC
cord-022353-q2k2krnm	59	24	their	-PRON-	PRP$
cord-022353-q2k2krnm	59	25	roles	role	NNS
cord-022353-q2k2krnm	59	26	in	in	IN
cord-022353-q2k2krnm	59	27	the	the	DT
cord-022353-q2k2krnm	59	28	pathogenesis	pathogenesis	NN
cord-022353-q2k2krnm	59	29	of	of	IN
cord-022353-q2k2krnm	59	30	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	59	31	discussed	discuss	VBN
cord-022353-q2k2krnm	59	32	in	in	IN
cord-022353-q2k2krnm	59	33	the	the	DT
cord-022353-q2k2krnm	59	34	"	"	``
cord-022353-q2k2krnm	59	35	Atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	59	36	"	"	''
cord-022353-q2k2krnm	59	37	section	section	NN
cord-022353-q2k2krnm	59	38	.	.	.
cord-022353-q2k2krnm	60	1	Plasma	plasma	NN
cord-022353-q2k2krnm	60	2	protein	protein	NN
cord-022353-q2k2krnm	60	3	profiling	profiling	NN
cord-022353-q2k2krnm	60	4	in	in	IN
cord-022353-q2k2krnm	60	5	mice	mouse	NNS
cord-022353-q2k2krnm	60	6	has	have	VBZ
cord-022353-q2k2krnm	60	7	the	the	DT
cord-022353-q2k2krnm	60	8	potential	potential	NN
cord-022353-q2k2krnm	60	9	to	to	TO
cord-022353-q2k2krnm	60	10	become	become	VB
cord-022353-q2k2krnm	60	11	an	an	DT
cord-022353-q2k2krnm	60	12	important	important	JJ
cord-022353-q2k2krnm	60	13	discovery	discovery	NN
cord-022353-q2k2krnm	60	14	tool	tool	NN
cord-022353-q2k2krnm	60	15	for	for	IN
cord-022353-q2k2krnm	60	16	translational	translational	JJ
cord-022353-q2k2krnm	60	17	research	research	NN
cord-022353-q2k2krnm	60	18	,	,	,
cord-022353-q2k2krnm	60	19	particularly	particularly	RB
cord-022353-q2k2krnm	60	20	in	in	IN
cord-022353-q2k2krnm	60	21	identifying	identify	VBG
cord-022353-q2k2krnm	60	22	cancer	cancer	NN
cord-022353-q2k2krnm	60	23	-	-	HYPH
cord-022353-q2k2krnm	60	24	associated	associate	VBN
cord-022353-q2k2krnm	60	25	plasma	plasma	NN
cord-022353-q2k2krnm	60	26	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	60	27	in	in	IN
cord-022353-q2k2krnm	60	28	humans	human	NNS
cord-022353-q2k2krnm	60	29	.	.	.
cord-022353-q2k2krnm	61	1	For	for	IN
cord-022353-q2k2krnm	61	2	example	example	NN
cord-022353-q2k2krnm	61	3	,	,	,
cord-022353-q2k2krnm	61	4	Juan	Juan	NNP
cord-022353-q2k2krnm	61	5	et	et	NNP
cord-022353-q2k2krnm	61	6	al	al	NNP
cord-022353-q2k2krnm	61	7	.	.	.
cord-022353-q2k2krnm	62	1	(	(	-LRB-
cord-022353-q2k2krnm	62	2	2004	2004	CD
cord-022353-q2k2krnm	62	3	)	)	-RRB-
cord-022353-q2k2krnm	62	4	also	also	RB
cord-022353-q2k2krnm	62	5	used	use	VBD
cord-022353-q2k2krnm	62	6	2D	2D	NNP
cord-022353-q2k2krnm	62	7	-	-	HYPH
cord-022353-q2k2krnm	62	8	GE	GE	NNP
cord-022353-q2k2krnm	62	9	and	and	CC
cord-022353-q2k2krnm	62	10	MALDI	MALDI	NNP
cord-022353-q2k2krnm	62	11	TOF	TOF	NNP
cord-022353-q2k2krnm	62	12	MS	MS	NNP
cord-022353-q2k2krnm	62	13	to	to	TO
cord-022353-q2k2krnm	62	14	identify	identify	VB
cord-022353-q2k2krnm	62	15	plasma	plasma	NN
cord-022353-q2k2krnm	62	16	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	62	17	in	in	IN
cord-022353-q2k2krnm	62	18	BALB	BALB	NNP
cord-022353-q2k2krnm	62	19	/	/	SYM
cord-022353-q2k2krnm	62	20	c	c	NNP
cord-022353-q2k2krnm	62	21	-	-	HYPH
cord-022353-q2k2krnm	62	22	nude	nude	JJ
cord-022353-q2k2krnm	62	23	mice	mouse	NNS
cord-022353-q2k2krnm	62	24	harboring	harbor	VBG
cord-022353-q2k2krnm	62	25	human	human	JJ
cord-022353-q2k2krnm	62	26	xenotransplanted	xenotransplante	VBN
cord-022353-q2k2krnm	62	27	tumors	tumor	NNS
cord-022353-q2k2krnm	62	28	.	.	.
cord-022353-q2k2krnm	63	1	In	in	IN
cord-022353-q2k2krnm	63	2	mice	mouse	NNS
cord-022353-q2k2krnm	63	3	bearing	bear	VBG
cord-022353-q2k2krnm	63	4	a	a	DT
cord-022353-q2k2krnm	63	5	human	human	JJ
cord-022353-q2k2krnm	63	6	stomach	stomach	NN
cord-022353-q2k2krnm	63	7	cancer	cancer	NN
cord-022353-q2k2krnm	63	8	cell	cell	NN
cord-022353-q2k2krnm	63	9	line	line	NN
cord-022353-q2k2krnm	63	10	,	,	,
cord-022353-q2k2krnm	63	11	serum	serum	NN
cord-022353-q2k2krnm	63	12	amyloid	amyloid	NN
cord-022353-q2k2krnm	63	13	A	A	NNP
cord-022353-q2k2krnm	63	14	(	(	-LRB-
cord-022353-q2k2krnm	63	15	SAA	SAA	NNP
cord-022353-q2k2krnm	63	16	)	)	-RRB-
cord-022353-q2k2krnm	63	17	was	be	VBD
cord-022353-q2k2krnm	63	18	elevated	elevate	VBN
cord-022353-q2k2krnm	63	19	.	.	.
cord-022353-q2k2krnm	64	1	The	the	DT
cord-022353-q2k2krnm	64	2	authors	author	NNS
cord-022353-q2k2krnm	64	3	then	then	RB
cord-022353-q2k2krnm	64	4	went	go	VBD
cord-022353-q2k2krnm	64	5	back	back	RB
cord-022353-q2k2krnm	64	6	to	to	TO
cord-022353-q2k2krnm	64	7	screen	screen	NN
cord-022353-q2k2krnm	64	8	the	the	DT
cord-022353-q2k2krnm	64	9	sera	sera	NNP
cord-022353-q2k2krnm	64	10	of	of	IN
cord-022353-q2k2krnm	64	11	human	human	JJ
cord-022353-q2k2krnm	64	12	stomach	stomach	NN
cord-022353-q2k2krnm	64	13	cancer	cancer	NN
cord-022353-q2k2krnm	64	14	patients	patient	NNS
cord-022353-q2k2krnm	64	15	and	and	CC
cord-022353-q2k2krnm	64	16	were	be	VBD
cord-022353-q2k2krnm	64	17	able	able	JJ
cord-022353-q2k2krnm	64	18	to	to	TO
cord-022353-q2k2krnm	64	19	demonstrate	demonstrate	VB
cord-022353-q2k2krnm	64	20	that	that	DT
cord-022353-q2k2krnm	64	21	,	,	,
cord-022353-q2k2krnm	64	22	when	when	WRB
cord-022353-q2k2krnm	64	23	compared	compare	VBN
cord-022353-q2k2krnm	64	24	to	to	IN
cord-022353-q2k2krnm	64	25	controls	control	NNS
cord-022353-q2k2krnm	64	26	,	,	,
cord-022353-q2k2krnm	64	27	humans	human	NNS
cord-022353-q2k2krnm	64	28	with	with	IN
cord-022353-q2k2krnm	64	29	stomach	stomach	NN
cord-022353-q2k2krnm	64	30	cancer	cancer	NN
cord-022353-q2k2krnm	64	31	also	also	RB
cord-022353-q2k2krnm	64	32	had	have	VBD
cord-022353-q2k2krnm	64	33	significantly	significantly	RB
cord-022353-q2k2krnm	64	34	elevated	elevate	VBN
cord-022353-q2k2krnm	64	35	levels	level	NNS
cord-022353-q2k2krnm	64	36	of	of	IN
cord-022353-q2k2krnm	64	37	SAA	SAA	NNP
cord-022353-q2k2krnm	64	38	.	.	.
cord-022353-q2k2krnm	65	1	All	all	DT
cord-022353-q2k2krnm	65	2	of	of	IN
cord-022353-q2k2krnm	65	3	these	these	DT
cord-022353-q2k2krnm	65	4	examples	example	NNS
cord-022353-q2k2krnm	65	5	illustrate	illustrate	VBP
cord-022353-q2k2krnm	65	6	the	the	DT
cord-022353-q2k2krnm	65	7	power	power	NN
cord-022353-q2k2krnm	65	8	of	of	IN
cord-022353-q2k2krnm	65	9	proteomics	proteomic	NNS
cord-022353-q2k2krnm	65	10	.	.	.
cord-022353-q2k2krnm	66	1	Proteomic	proteomic	JJ
cord-022353-q2k2krnm	66	2	pattern	pattern	NN
cord-022353-q2k2krnm	66	3	diagnostics	diagnostic	NNS
cord-022353-q2k2krnm	66	4	offers	offer	VBZ
cord-022353-q2k2krnm	66	5	a	a	DT
cord-022353-q2k2krnm	66	6	means	means	NN
cord-022353-q2k2krnm	66	7	to	to	TO
cord-022353-q2k2krnm	66	8	look	look	VB
cord-022353-q2k2krnm	66	9	at	at	IN
cord-022353-q2k2krnm	66	10	molecular	molecular	JJ
cord-022353-q2k2krnm	66	11	diagnostic	diagnostic	JJ
cord-022353-q2k2krnm	66	12	information	information	NN
cord-022353-q2k2krnm	66	13	in	in	IN
cord-022353-q2k2krnm	66	14	human	human	JJ
cord-022353-q2k2krnm	66	15	or	or	CC
cord-022353-q2k2krnm	66	16	mouse	mouse	NN
cord-022353-q2k2krnm	66	17	serum	serum	NN
cord-022353-q2k2krnm	66	18	,	,	,
cord-022353-q2k2krnm	66	19	without	without	IN
cord-022353-q2k2krnm	66	20	preconceived	preconceived	JJ
cord-022353-q2k2krnm	66	21	assumptions	assumption	NNS
cord-022353-q2k2krnm	66	22	about	about	IN
cord-022353-q2k2krnm	66	23	the	the	DT
cord-022353-q2k2krnm	66	24	existence	existence	NN
cord-022353-q2k2krnm	66	25	or	or	CC
cord-022353-q2k2krnm	66	26	identity	identity	NN
cord-022353-q2k2krnm	66	27	of	of	IN
cord-022353-q2k2krnm	66	28	the	the	DT
cord-022353-q2k2krnm	66	29	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	66	30	.	.	.
cord-022353-q2k2krnm	67	1	This	this	DT
cord-022353-q2k2krnm	67	2	allows	allow	VBZ
cord-022353-q2k2krnm	67	3	for	for	IN
cord-022353-q2k2krnm	67	4	the	the	DT
cord-022353-q2k2krnm	67	5	development	development	NN
cord-022353-q2k2krnm	67	6	of	of	IN
cord-022353-q2k2krnm	67	7	sensitive	sensitive	JJ
cord-022353-q2k2krnm	67	8	and	and	CC
cord-022353-q2k2krnm	67	9	specific	specific	JJ
cord-022353-q2k2krnm	67	10	peptide	peptide	JJ
cord-022353-q2k2krnm	67	11	assays	assay	NNS
cord-022353-q2k2krnm	67	12	for	for	IN
cord-022353-q2k2krnm	67	13	identified	identify	VBN
cord-022353-q2k2krnm	67	14	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	67	15	of	of	IN
cord-022353-q2k2krnm	67	16	disease	disease	NN
cord-022353-q2k2krnm	67	17	.	.	.
cord-022353-q2k2krnm	68	1	Practical	practical	JJ
cord-022353-q2k2krnm	68	2	applications	application	NNS
cord-022353-q2k2krnm	68	3	of	of	IN
cord-022353-q2k2krnm	68	4	proteomics	proteomic	NNS
cord-022353-q2k2krnm	68	5	have	have	VBP
cord-022353-q2k2krnm	68	6	been	be	VBN
cord-022353-q2k2krnm	68	7	facilitated	facilitate	VBN
cord-022353-q2k2krnm	68	8	by	by	IN
cord-022353-q2k2krnm	68	9	the	the	DT
cord-022353-q2k2krnm	68	10	creation	creation	NN
cord-022353-q2k2krnm	68	11	of	of	IN
cord-022353-q2k2krnm	68	12	instrumentation	instrumentation	NN
cord-022353-q2k2krnm	68	13	that	that	WDT
cord-022353-q2k2krnm	68	14	can	can	MD
cord-022353-q2k2krnm	68	15	analyze	analyze	VB
cord-022353-q2k2krnm	68	16	multiple	multiple	JJ
cord-022353-q2k2krnm	68	17	analytes	analyte	NNS
cord-022353-q2k2krnm	68	18	from	from	IN
cord-022353-q2k2krnm	68	19	small	small	JJ
cord-022353-q2k2krnm	68	20	sample	sample	NN
cord-022353-q2k2krnm	68	21	volumes	volume	NNS
cord-022353-q2k2krnm	68	22	with	with	IN
cord-022353-q2k2krnm	68	23	fast	fast	JJ
cord-022353-q2k2krnm	68	24	through	through	RB
cord-022353-q2k2krnm	68	25	-	-	HYPH
cord-022353-q2k2krnm	68	26	put	put	NN
cord-022353-q2k2krnm	68	27	(	(	-LRB-
cord-022353-q2k2krnm	68	28	such	such	JJ
cord-022353-q2k2krnm	68	29	as	as	IN
cord-022353-q2k2krnm	68	30	multiplex	multiplex	NN
cord-022353-q2k2krnm	68	31	technology	technology	NN
cord-022353-q2k2krnm	68	32	,	,	,
cord-022353-q2k2krnm	68	33	which	which	WDT
cord-022353-q2k2krnm	68	34	are	be	VBP
cord-022353-q2k2krnm	68	35	discussed	discuss	VBN
cord-022353-q2k2krnm	68	36	in	in	IN
cord-022353-q2k2krnm	68	37	the	the	DT
cord-022353-q2k2krnm	68	38	"	"	``
cord-022353-q2k2krnm	68	39	Multiplex	Multiplex	NNP
cord-022353-q2k2krnm	68	40	Technology	Technology	NNP
cord-022353-q2k2krnm	68	41	"	"	''
cord-022353-q2k2krnm	68	42	section	section	NN
cord-022353-q2k2krnm	68	43	)	)	-RRB-
cord-022353-q2k2krnm	68	44	.	.	.
cord-022353-q2k2krnm	69	1	In	in	IN
cord-022353-q2k2krnm	69	2	an	an	DT
cord-022353-q2k2krnm	69	3	attempt	attempt	NN
cord-022353-q2k2krnm	69	4	to	to	TO
cord-022353-q2k2krnm	69	5	manage	manage	VB
cord-022353-q2k2krnm	69	6	all	all	PDT
cord-022353-q2k2krnm	69	7	the	the	DT
cord-022353-q2k2krnm	69	8	experimental	experimental	JJ
cord-022353-q2k2krnm	69	9	data	datum	NNS
cord-022353-q2k2krnm	69	10	arising	arise	VBG
cord-022353-q2k2krnm	69	11	from	from	IN
cord-022353-q2k2krnm	69	12	the	the	DT
cord-022353-q2k2krnm	69	13	fields	field	NNS
cord-022353-q2k2krnm	69	14	of	of	IN
cord-022353-q2k2krnm	69	15	proteomics	proteomic	NNS
cord-022353-q2k2krnm	69	16	,	,	,
cord-022353-q2k2krnm	69	17	metabolomics	metabolomic	NNS
cord-022353-q2k2krnm	69	18	and	and	CC
cord-022353-q2k2krnm	69	19	transcriptomics	transcriptomic	NNS
cord-022353-q2k2krnm	69	20	(	(	-LRB-
cord-022353-q2k2krnm	69	21	gene	gene	NN
cord-022353-q2k2krnm	69	22	array	array	NN
cord-022353-q2k2krnm	69	23	)	)	-RRB-
cord-022353-q2k2krnm	69	24	,	,	,
cord-022353-q2k2krnm	69	25	the	the	DT
cord-022353-q2k2krnm	69	26	Chemical	Chemical	NNP
cord-022353-q2k2krnm	69	27	Effects	Effects	NNPS
cord-022353-q2k2krnm	69	28	in	in	IN
cord-022353-q2k2krnm	69	29	Biological	Biological	NNP
cord-022353-q2k2krnm	69	30	Systems	Systems	NNPS
cord-022353-q2k2krnm	69	31	(	(	-LRB-
cord-022353-q2k2krnm	69	32	CEBs	ceb	NNS
cord-022353-q2k2krnm	69	33	)	)	-RRB-
cord-022353-q2k2krnm	69	34	Knowledge	knowledge	NN
cord-022353-q2k2krnm	69	35	base	base	NN
cord-022353-q2k2krnm	69	36	was	be	VBD
cord-022353-q2k2krnm	69	37	developed	develop	VBN
cord-022353-q2k2krnm	69	38	(	(	-LRB-
cord-022353-q2k2krnm	69	39	Xirasagar	Xirasagar	NNP
cord-022353-q2k2krnm	69	40	et	et	FW
cord-022353-q2k2krnm	69	41	al	al	NNP
cord-022353-q2k2krnm	69	42	.	.	.
cord-022353-q2k2krnm	69	43	2004	2004	CD
cord-022353-q2k2krnm	69	44	)	)	-RRB-
cord-022353-q2k2krnm	69	45	.	.	.
cord-022353-q2k2krnm	70	1	This	this	DT
cord-022353-q2k2krnm	70	2	is	be	VBZ
cord-022353-q2k2krnm	70	3	a	a	DT
cord-022353-q2k2krnm	70	4	useful	useful	JJ
cord-022353-q2k2krnm	70	5	,	,	,
cord-022353-q2k2krnm	70	6	searchable	searchable	JJ
cord-022353-q2k2krnm	70	7	database	database	NN
cord-022353-q2k2krnm	70	8	that	that	WDT
cord-022353-q2k2krnm	70	9	integrates	integrate	VBZ
cord-022353-q2k2krnm	70	10	experimental	experimental	JJ
cord-022353-q2k2krnm	70	11	findings	finding	NNS
cord-022353-q2k2krnm	70	12	from	from	IN
cord-022353-q2k2krnm	70	13	all	all	DT
cord-022353-q2k2krnm	70	14	three	three	CD
cord-022353-q2k2krnm	70	15	disciplines	discipline	NNS
cord-022353-q2k2krnm	70	16	,	,	,
cord-022353-q2k2krnm	70	17	by	by	IN
cord-022353-q2k2krnm	70	18	biosource	biosource	NN
cord-022353-q2k2krnm	70	19	identification	identification	NN
cord-022353-q2k2krnm	70	20	(	(	-LRB-
cord-022353-q2k2krnm	70	21	animal	animal	NN
cord-022353-q2k2krnm	70	22	,	,	,
cord-022353-q2k2krnm	70	23	test	test	NN
cord-022353-q2k2krnm	70	24	article	article	NN
cord-022353-q2k2krnm	70	25	,	,	,
cord-022353-q2k2krnm	70	26	genotype	genotype	NN
cord-022353-q2k2krnm	70	27	,	,	,
cord-022353-q2k2krnm	70	28	and	and	CC
cord-022353-q2k2krnm	70	29	investigator	investigator	NN
cord-022353-q2k2krnm	70	30	)	)	-RRB-
cord-022353-q2k2krnm	70	31	.	.	.
cord-022353-q2k2krnm	71	1	By	by	IN
cord-022353-q2k2krnm	71	2	making	make	VBG
cord-022353-q2k2krnm	71	3	the	the	DT
cord-022353-q2k2krnm	71	4	cross	cross	JJ
cord-022353-q2k2krnm	71	5	correlation	correlation	NN
cord-022353-q2k2krnm	71	6	from	from	IN
cord-022353-q2k2krnm	71	7	data	datum	NNS
cord-022353-q2k2krnm	71	8	arising	arise	VBG
cord-022353-q2k2krnm	71	9	from	from	IN
cord-022353-q2k2krnm	71	10	three	three	CD
cord-022353-q2k2krnm	71	11	different	different	JJ
cord-022353-q2k2krnm	71	12	streams	stream	NNS
cord-022353-q2k2krnm	71	13	it	-PRON-	PRP
cord-022353-q2k2krnm	71	14	is	be	VBZ
cord-022353-q2k2krnm	71	15	hoped	hope	VBN
cord-022353-q2k2krnm	71	16	that	that	IN
cord-022353-q2k2krnm	71	17	combination	combination	NN
cord-022353-q2k2krnm	71	18	groups	group	NNS
cord-022353-q2k2krnm	71	19	of	of	IN
cord-022353-q2k2krnm	71	20	predictive	predictive	JJ
cord-022353-q2k2krnm	71	21	markers	marker	NNS
cord-022353-q2k2krnm	71	22	for	for	IN
cord-022353-q2k2krnm	71	23	disease	disease	NN
cord-022353-q2k2krnm	71	24	and	and	CC
cord-022353-q2k2krnm	71	25	toxicity	toxicity	NN
cord-022353-q2k2krnm	71	26	will	will	MD
cord-022353-q2k2krnm	71	27	emerge	emerge	VB
cord-022353-q2k2krnm	71	28	.	.	.
cord-022353-q2k2krnm	72	1	The	the	DT
cord-022353-q2k2krnm	72	2	cost	cost	NN
cord-022353-q2k2krnm	72	3	of	of	IN
cord-022353-q2k2krnm	72	4	bringing	bring	VBG
cord-022353-q2k2krnm	72	5	a	a	DT
cord-022353-q2k2krnm	72	6	new	new	JJ
cord-022353-q2k2krnm	72	7	drug	drug	NN
cord-022353-q2k2krnm	72	8	to	to	IN
cord-022353-q2k2krnm	72	9	market	market	NN
cord-022353-q2k2krnm	72	10	is	be	VBZ
cord-022353-q2k2krnm	72	11	estimated	estimate	VBN
cord-022353-q2k2krnm	72	12	at	at	IN
cord-022353-q2k2krnm	72	13	$	$	$
cord-022353-q2k2krnm	72	14	0.8	0.8	CD
cord-022353-q2k2krnm	72	15	-	-	SYM
cord-022353-q2k2krnm	72	16	1.7	1.7	CD
cord-022353-q2k2krnm	72	17	billion	billion	CD
cord-022353-q2k2krnm	72	18	(	(	-LRB-
cord-022353-q2k2krnm	72	19	Food	Food	NNP
cord-022353-q2k2krnm	72	20	and	and	CC
cord-022353-q2k2krnm	72	21	Drug	Drug	NNP
cord-022353-q2k2krnm	72	22	Administration	Administration	NNP
cord-022353-q2k2krnm	72	23	2004	2004	CD
cord-022353-q2k2krnm	72	24	)	)	-RRB-
cord-022353-q2k2krnm	72	25	,	,	,
cord-022353-q2k2krnm	72	26	of	of	IN
cord-022353-q2k2krnm	72	27	which	which	WDT
cord-022353-q2k2krnm	72	28	a	a	DT
cord-022353-q2k2krnm	72	29	large	large	JJ
cord-022353-q2k2krnm	72	30	proportion	proportion	NN
cord-022353-q2k2krnm	72	31	is	be	VBZ
cord-022353-q2k2krnm	72	32	spent	spend	VBN
cord-022353-q2k2krnm	72	33	on	on	IN
cord-022353-q2k2krnm	72	34	safety	safety	NN
cord-022353-q2k2krnm	72	35	/	/	SYM
cord-022353-q2k2krnm	72	36	toxicity	toxicity	NN
cord-022353-q2k2krnm	72	37	assessments	assessment	NNS
cord-022353-q2k2krnm	72	38	during	during	IN
cord-022353-q2k2krnm	72	39	the	the	DT
cord-022353-q2k2krnm	72	40	preclinical	preclinical	JJ
cord-022353-q2k2krnm	72	41	phase	phase	NN
cord-022353-q2k2krnm	72	42	of	of	IN
cord-022353-q2k2krnm	72	43	the	the	DT
cord-022353-q2k2krnm	72	44	development	development	NN
cord-022353-q2k2krnm	72	45	of	of	IN
cord-022353-q2k2krnm	72	46	a	a	DT
cord-022353-q2k2krnm	72	47	drug	drug	NN
cord-022353-q2k2krnm	72	48	.	.	.
cord-022353-q2k2krnm	73	1	Although	although	IN
cord-022353-q2k2krnm	73	2	expensive	expensive	JJ
cord-022353-q2k2krnm	73	3	,	,	,
cord-022353-q2k2krnm	73	4	safety	safety	NN
cord-022353-q2k2krnm	73	5	/	/	SYM
cord-022353-q2k2krnm	73	6	toxicity	toxicity	NN
cord-022353-q2k2krnm	73	7	regulations	regulation	NNS
cord-022353-q2k2krnm	73	8	are	be	VBP
cord-022353-q2k2krnm	73	9	necessary	necessary	JJ
cord-022353-q2k2krnm	73	10	,	,	,
cord-022353-q2k2krnm	73	11	as	as	IN
cord-022353-q2k2krnm	73	12	illustrated	illustrate	VBN
cord-022353-q2k2krnm	73	13	by	by	IN
cord-022353-q2k2krnm	73	14	the	the	DT
cord-022353-q2k2krnm	73	15	fact	fact	NN
cord-022353-q2k2krnm	73	16	that	that	IN
cord-022353-q2k2krnm	73	17	a	a	DT
cord-022353-q2k2krnm	73	18	new	new	JJ
cord-022353-q2k2krnm	73	19	drug	drug	NN
cord-022353-q2k2krnm	73	20	entering	enter	VBG
cord-022353-q2k2krnm	73	21	Phase	phase	NN
cord-022353-q2k2krnm	74	1	I	-PRON-	PRP
cord-022353-q2k2krnm	74	2	clinical	clinical	JJ
cord-022353-q2k2krnm	74	3	trials	trial	NNS
cord-022353-q2k2krnm	74	4	has	have	VBZ
cord-022353-q2k2krnm	74	5	only	only	RB
cord-022353-q2k2krnm	74	6	an	an	DT
cord-022353-q2k2krnm	74	7	8	8	CD
cord-022353-q2k2krnm	74	8	%	%	NN
cord-022353-q2k2krnm	74	9	chance	chance	NN
cord-022353-q2k2krnm	74	10	of	of	IN
cord-022353-q2k2krnm	74	11	reaching	reach	VBG
cord-022353-q2k2krnm	74	12	the	the	DT
cord-022353-q2k2krnm	74	13	marketplace	marketplace	NN
cord-022353-q2k2krnm	74	14	due	due	JJ
cord-022353-q2k2krnm	74	15	to	to	IN
cord-022353-q2k2krnm	74	16	toxicity	toxicity	NN
cord-022353-q2k2krnm	74	17	issues	issue	NNS
cord-022353-q2k2krnm	74	18	.	.	.
cord-022353-q2k2krnm	75	1	The	the	DT
cord-022353-q2k2krnm	75	2	ability	ability	NN
cord-022353-q2k2krnm	75	3	to	to	TO
cord-022353-q2k2krnm	75	4	decrease	decrease	VB
cord-022353-q2k2krnm	75	5	the	the	DT
cord-022353-q2k2krnm	75	6	costs	cost	NNS
cord-022353-q2k2krnm	75	7	of	of	IN
cord-022353-q2k2krnm	75	8	drug	drug	NN
cord-022353-q2k2krnm	75	9	development	development	NN
cord-022353-q2k2krnm	75	10	due	due	IN
cord-022353-q2k2krnm	75	11	to	to	IN
cord-022353-q2k2krnm	75	12	safety	safety	NN
cord-022353-q2k2krnm	75	13	/	/	SYM
cord-022353-q2k2krnm	75	14	toxicity	toxicity	NN
cord-022353-q2k2krnm	75	15	issues	issue	NNS
cord-022353-q2k2krnm	75	16	is	be	VBZ
cord-022353-q2k2krnm	75	17	becoming	become	VBG
cord-022353-q2k2krnm	75	18	increasingly	increasingly	RB
cord-022353-q2k2krnm	75	19	reliant	reliant	JJ
cord-022353-q2k2krnm	75	20	on	on	IN
cord-022353-q2k2krnm	75	21	the	the	DT
cord-022353-q2k2krnm	75	22	use	use	NN
cord-022353-q2k2krnm	75	23	of	of	IN
cord-022353-q2k2krnm	75	24	the	the	DT
cord-022353-q2k2krnm	75	25	laboratory	laboratory	NN
cord-022353-q2k2krnm	75	26	mouse	mouse	NN
cord-022353-q2k2krnm	75	27	as	as	IN
cord-022353-q2k2krnm	75	28	a	a	DT
cord-022353-q2k2krnm	75	29	model	model	NN
cord-022353-q2k2krnm	75	30	for	for	IN
cord-022353-q2k2krnm	75	31	human	human	JJ
cord-022353-q2k2krnm	75	32	disease	disease	NN
cord-022353-q2k2krnm	75	33	and	and	CC
cord-022353-q2k2krnm	75	34	the	the	DT
cord-022353-q2k2krnm	75	35	identification	identification	NN
cord-022353-q2k2krnm	75	36	of	of	IN
cord-022353-q2k2krnm	75	37	sensitive	sensitive	JJ
cord-022353-q2k2krnm	75	38	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	75	39	for	for	IN
cord-022353-q2k2krnm	75	40	toxicity	toxicity	NN
cord-022353-q2k2krnm	75	41	and	and	CC
cord-022353-q2k2krnm	75	42	disease	disease	NN
cord-022353-q2k2krnm	75	43	.	.	.
cord-022353-q2k2krnm	76	1	The	the	DT
cord-022353-q2k2krnm	76	2	underlying	underlying	JJ
cord-022353-q2k2krnm	76	3	basis	basis	NN
cord-022353-q2k2krnm	76	4	of	of	IN
cord-022353-q2k2krnm	76	5	using	use	VBG
cord-022353-q2k2krnm	76	6	laboratory	laboratory	NN
cord-022353-q2k2krnm	76	7	mice	mouse	NNS
cord-022353-q2k2krnm	76	8	as	as	IN
cord-022353-q2k2krnm	76	9	models	model	NNS
cord-022353-q2k2krnm	76	10	for	for	IN
cord-022353-q2k2krnm	76	11	human	human	JJ
cord-022353-q2k2krnm	76	12	disease	disease	NN
cord-022353-q2k2krnm	76	13	was	be	VBD
cord-022353-q2k2krnm	76	14	demonstrated	demonstrate	VBN
cord-022353-q2k2krnm	76	15	by	by	IN
cord-022353-q2k2krnm	76	16	Everett	Everett	NNP
cord-022353-q2k2krnm	76	17	and	and	CC
cord-022353-q2k2krnm	76	18	Harrison	Harrison	NNP
cord-022353-q2k2krnm	76	19	(	(	-LRB-
cord-022353-q2k2krnm	76	20	1983	1983	CD
cord-022353-q2k2krnm	76	21	)	)	-RRB-
cord-022353-q2k2krnm	76	22	,	,	,
cord-022353-q2k2krnm	76	23	who	who	WP
cord-022353-q2k2krnm	76	24	showed	show	VBD
cord-022353-q2k2krnm	76	25	that	that	IN
cord-022353-q2k2krnm	76	26	the	the	DT
cord-022353-q2k2krnm	76	27	predictive	predictive	JJ
cord-022353-q2k2krnm	76	28	reliability	reliability	NN
cord-022353-q2k2krnm	76	29	of	of	IN
cord-022353-q2k2krnm	76	30	mice	mouse	NNS
cord-022353-q2k2krnm	76	31	for	for	IN
cord-022353-q2k2krnm	76	32	quantitative	quantitative	JJ
cord-022353-q2k2krnm	76	33	toxicity	toxicity	NN
cord-022353-q2k2krnm	76	34	of	of	IN
cord-022353-q2k2krnm	76	35	five	five	CD
cord-022353-q2k2krnm	76	36	chemotherapeutic	chemotherapeutic	JJ
cord-022353-q2k2krnm	76	37	drugs	drug	NNS
cord-022353-q2k2krnm	76	38	in	in	IN
cord-022353-q2k2krnm	76	39	humans	human	NNS
cord-022353-q2k2krnm	76	40	was	be	VBD
cord-022353-q2k2krnm	76	41	at	at	RB
cord-022353-q2k2krnm	76	42	least	least	JJS
cord-022353-q2k2krnm	76	43	as	as	RB
cord-022353-q2k2krnm	76	44	good	good	JJ
cord-022353-q2k2krnm	76	45	,	,	,
cord-022353-q2k2krnm	76	46	if	if	IN
cord-022353-q2k2krnm	76	47	not	not	RB
cord-022353-q2k2krnm	76	48	better	well	JJR
cord-022353-q2k2krnm	76	49	,	,	,
cord-022353-q2k2krnm	76	50	that	that	IN
cord-022353-q2k2krnm	76	51	the	the	DT
cord-022353-q2k2krnm	76	52	predictive	predictive	JJ
cord-022353-q2k2krnm	76	53	reliability	reliability	NN
cord-022353-q2k2krnm	76	54	demonstrative	demonstrative	JJ
cord-022353-q2k2krnm	76	55	by	by	IN
cord-022353-q2k2krnm	76	56	dogs	dog	NNS
cord-022353-q2k2krnm	76	57	and	and	CC
cord-022353-q2k2krnm	76	58	monkeys	monkey	NNS
cord-022353-q2k2krnm	76	59	.	.	.
cord-022353-q2k2krnm	77	1	More	more	RBR
cord-022353-q2k2krnm	77	2	recently	recently	RB
cord-022353-q2k2krnm	77	3	,	,	,
cord-022353-q2k2krnm	77	4	Newell	Newell	NNP
cord-022353-q2k2krnm	77	5	et	et	NNP
cord-022353-q2k2krnm	77	6	al	al	NNP
cord-022353-q2k2krnm	77	7	.	.	.
cord-022353-q2k2krnm	78	1	(	(	-LRB-
cord-022353-q2k2krnm	78	2	2004	2004	CD
cord-022353-q2k2krnm	78	3	)	)	-RRB-
cord-022353-q2k2krnm	78	4	presented	present	VBD
cord-022353-q2k2krnm	78	5	data	datum	NNS
cord-022353-q2k2krnm	78	6	on	on	IN
cord-022353-q2k2krnm	78	7	predictive	predictive	JJ
cord-022353-q2k2krnm	78	8	performance	performance	NN
cord-022353-q2k2krnm	78	9	of	of	IN
cord-022353-q2k2krnm	78	10	rats	rat	NNS
cord-022353-q2k2krnm	78	11	and	and	CC
cord-022353-q2k2krnm	78	12	mice	mouse	NNS
cord-022353-q2k2krnm	78	13	to	to	TO
cord-022353-q2k2krnm	78	14	demonstrate	demonstrate	VB
cord-022353-q2k2krnm	78	15	qualitative	qualitative	JJ
cord-022353-q2k2krnm	78	16	human	human	JJ
cord-022353-q2k2krnm	78	17	toxicity	toxicity	NN
cord-022353-q2k2krnm	78	18	when	when	WRB
cord-022353-q2k2krnm	78	19	given	give	VBN
cord-022353-q2k2krnm	78	20	39	39	CD
cord-022353-q2k2krnm	78	21	novel	novel	JJ
cord-022353-q2k2krnm	78	22	cancer	cancer	NN
cord-022353-q2k2krnm	78	23	chemotherapeutic	chemotherapeutic	VBN
cord-022353-q2k2krnm	78	24	agents	agent	NNS
cord-022353-q2k2krnm	78	25	.	.	.
cord-022353-q2k2krnm	79	1	They	-PRON-	PRP
cord-022353-q2k2krnm	79	2	claim	claim	VBP
cord-022353-q2k2krnm	79	3	that	that	IN
cord-022353-q2k2krnm	79	4	nonrodent	nonrodent	NNP
cord-022353-q2k2krnm	79	5	species	specie	NNS
cord-022353-q2k2krnm	79	6	are	be	VBP
cord-022353-q2k2krnm	79	7	unnecessary	unnecessary	JJ
cord-022353-q2k2krnm	79	8	for	for	IN
cord-022353-q2k2krnm	79	9	identification	identification	NN
cord-022353-q2k2krnm	79	10	of	of	IN
cord-022353-q2k2krnm	79	11	a	a	DT
cord-022353-q2k2krnm	79	12	safe	safe	JJ
cord-022353-q2k2krnm	79	13	Phase	phase	NN
cord-022353-q2k2krnm	79	14	1	1	CD
cord-022353-q2k2krnm	79	15	starting	starting	NN
cord-022353-q2k2krnm	79	16	dose	dose	NN
cord-022353-q2k2krnm	79	17	for	for	IN
cord-022353-q2k2krnm	79	18	human	human	JJ
cord-022353-q2k2krnm	79	19	trials	trial	NNS
cord-022353-q2k2krnm	79	20	.	.	.
cord-022353-q2k2krnm	80	1	Furthermore	furthermore	RB
cord-022353-q2k2krnm	80	2	,	,	,
cord-022353-q2k2krnm	80	3	the	the	DT
cord-022353-q2k2krnm	80	4	two	two	CD
cord-022353-q2k2krnm	80	5	rodent	rodent	NN
cord-022353-q2k2krnm	80	6	species	specie	NNS
cord-022353-q2k2krnm	80	7	(	(	-LRB-
cord-022353-q2k2krnm	80	8	rats	rat	NNS
cord-022353-q2k2krnm	80	9	and	and	CC
cord-022353-q2k2krnm	80	10	mice	mouse	NNS
cord-022353-q2k2krnm	80	11	)	)	-RRB-
cord-022353-q2k2krnm	80	12	used	use	VBD
cord-022353-q2k2krnm	80	13	gave	give	VBD
cord-022353-q2k2krnm	80	14	similar	similar	JJ
cord-022353-q2k2krnm	80	15	quantitative	quantitative	JJ
cord-022353-q2k2krnm	80	16	and	and	CC
cord-022353-q2k2krnm	80	17	qualitative	qualitative	JJ
cord-022353-q2k2krnm	80	18	results	result	NNS
cord-022353-q2k2krnm	80	19	.	.	.
cord-022353-q2k2krnm	81	1	The	the	DT
cord-022353-q2k2krnm	81	2	arrival	arrival	NN
cord-022353-q2k2krnm	81	3	of	of	IN
cord-022353-q2k2krnm	81	4	genetically	genetically	RB
cord-022353-q2k2krnm	81	5	engineered	engineer	VBN
cord-022353-q2k2krnm	81	6	mice	mouse	NNS
cord-022353-q2k2krnm	81	7	has	have	VBZ
cord-022353-q2k2krnm	81	8	further	further	RB
cord-022353-q2k2krnm	81	9	enhanced	enhance	VBN
cord-022353-q2k2krnm	81	10	the	the	DT
cord-022353-q2k2krnm	81	11	relevance	relevance	NN
cord-022353-q2k2krnm	81	12	of	of	IN
cord-022353-q2k2krnm	81	13	using	use	VBG
cord-022353-q2k2krnm	81	14	mice	mouse	NNS
cord-022353-q2k2krnm	81	15	in	in	IN
cord-022353-q2k2krnm	81	16	research	research	NN
cord-022353-q2k2krnm	81	17	,	,	,
cord-022353-q2k2krnm	81	18	especially	especially	RB
cord-022353-q2k2krnm	81	19	in	in	IN
cord-022353-q2k2krnm	81	20	terms	term	NNS
cord-022353-q2k2krnm	81	21	of	of	IN
cord-022353-q2k2krnm	81	22	basic	basic	JJ
cord-022353-q2k2krnm	81	23	mechanistic	mechanistic	JJ
cord-022353-q2k2krnm	81	24	research	research	NN
cord-022353-q2k2krnm	81	25	and	and	CC
cord-022353-q2k2krnm	81	26	applied	apply	VBD
cord-022353-q2k2krnm	81	27	screening	screening	NN
cord-022353-q2k2krnm	81	28	for	for	IN
cord-022353-q2k2krnm	81	29	genotoxicity	genotoxicity	NN
cord-022353-q2k2krnm	81	30	and	and	CC
cord-022353-q2k2krnm	81	31	carcinogenicity	carcinogenicity	NN
cord-022353-q2k2krnm	81	32	.	.	.
cord-022353-q2k2krnm	82	1	Transgenic	transgenic	JJ
cord-022353-q2k2krnm	82	2	mice	mouse	NNS
cord-022353-q2k2krnm	82	3	carrying	carry	VBG
cord-022353-q2k2krnm	82	4	a	a	DT
cord-022353-q2k2krnm	82	5	human	human	JJ
cord-022353-q2k2krnm	82	6	gene	gene	NN
cord-022353-q2k2krnm	82	7	and	and	CC
cord-022353-q2k2krnm	82	8	expressing	express	VBG
cord-022353-q2k2krnm	82	9	the	the	DT
cord-022353-q2k2krnm	82	10	protein	protein	NN
cord-022353-q2k2krnm	82	11	are	be	VBP
cord-022353-q2k2krnm	82	12	said	say	VBN
cord-022353-q2k2krnm	82	13	to	to	TO
cord-022353-q2k2krnm	82	14	be	be	VB
cord-022353-q2k2krnm	82	15	"	"	``
cord-022353-q2k2krnm	82	16	humanized	humanize	VBN
cord-022353-q2k2krnm	82	17	.	.	.
cord-022353-q2k2krnm	82	18	"	"	''
cord-022353-q2k2krnm	83	1	These	these	DT
cord-022353-q2k2krnm	83	2	animals	animal	NNS
cord-022353-q2k2krnm	83	3	are	be	VBP
cord-022353-q2k2krnm	83	4	invaluable	invaluable	JJ
cord-022353-q2k2krnm	83	5	in	in	IN
cord-022353-q2k2krnm	83	6	drug	drug	NN
cord-022353-q2k2krnm	83	7	assessment	assessment	NN
cord-022353-q2k2krnm	83	8	especially	especially	RB
cord-022353-q2k2krnm	83	9	when	when	WRB
cord-022353-q2k2krnm	83	10	the	the	DT
cord-022353-q2k2krnm	83	11	drug	drug	NN
cord-022353-q2k2krnm	83	12	interacts	interact	VBZ
cord-022353-q2k2krnm	83	13	only	only	RB
cord-022353-q2k2krnm	83	14	with	with	IN
cord-022353-q2k2krnm	83	15	the	the	DT
cord-022353-q2k2krnm	83	16	human	human	JJ
cord-022353-q2k2krnm	83	17	protein	protein	NN
cord-022353-q2k2krnm	83	18	(	(	-LRB-
cord-022353-q2k2krnm	83	19	Bolon	Bolon	NNP
cord-022353-q2k2krnm	83	20	2004	2004	CD
cord-022353-q2k2krnm	83	21	)	)	-RRB-
cord-022353-q2k2krnm	83	22	.	.	.
cord-022353-q2k2krnm	84	1	Zambrowicz	Zambrowicz	NNP
cord-022353-q2k2krnm	84	2	and	and	CC
cord-022353-q2k2krnm	84	3	Sands	Sands	NNPS
cord-022353-q2k2krnm	84	4	(	(	-LRB-
cord-022353-q2k2krnm	84	5	2003a	2003a	CD
cord-022353-q2k2krnm	84	6	)	)	-RRB-
cord-022353-q2k2krnm	84	7	showed	show	VBD
cord-022353-q2k2krnm	84	8	that	that	IN
cord-022353-q2k2krnm	84	9	the	the	DT
cord-022353-q2k2krnm	84	10	KO	KO	NNP
cord-022353-q2k2krnm	84	11	phenotype	phenotype	NN
cord-022353-q2k2krnm	84	12	of	of	IN
cord-022353-q2k2krnm	84	13	mice	mouse	NNS
cord-022353-q2k2krnm	84	14	correlated	correlate	VBN
cord-022353-q2k2krnm	84	15	well	well	RB
cord-022353-q2k2krnm	84	16	with	with	IN
cord-022353-q2k2krnm	84	17	the	the	DT
cord-022353-q2k2krnm	84	18	molecular	molecular	JJ
cord-022353-q2k2krnm	84	19	targets	target	NNS
cord-022353-q2k2krnm	84	20	of	of	IN
cord-022353-q2k2krnm	84	21	the	the	DT
cord-022353-q2k2krnm	84	22	100	100	CD
cord-022353-q2k2krnm	84	23	best	good	JJS
cord-022353-q2k2krnm	84	24	selling	sell	VBG
cord-022353-q2k2krnm	84	25	drugs	drug	NNS
cord-022353-q2k2krnm	84	26	available	available	JJ
cord-022353-q2k2krnm	84	27	to	to	IN
cord-022353-q2k2krnm	84	28	the	the	DT
cord-022353-q2k2krnm	84	29	U.S.	U.S.	NNP
cord-022353-q2k2krnm	84	30	market	market	NN
cord-022353-q2k2krnm	84	31	.	.	.
cord-022353-q2k2krnm	85	1	Zambrowicz	Zambrowicz	NNP
cord-022353-q2k2krnm	85	2	et	et	FW
cord-022353-q2k2krnm	85	3	al	al	NNP
cord-022353-q2k2krnm	85	4	.	.	.
cord-022353-q2k2krnm	86	1	(	(	-LRB-
cord-022353-q2k2krnm	86	2	2003b	2003b	CD
cord-022353-q2k2krnm	86	3	)	)	-RRB-
cord-022353-q2k2krnm	87	1	compared	compare	VBN
cord-022353-q2k2krnm	87	2	the	the	DT
cord-022353-q2k2krnm	87	3	physiology	physiology	NN
cord-022353-q2k2krnm	87	4	of	of	IN
cord-022353-q2k2krnm	87	5	KO	KO	NNP
cord-022353-q2k2krnm	87	6	mice	mouse	NNS
cord-022353-q2k2krnm	87	7	,	,	,
cord-022353-q2k2krnm	87	8	where	where	WRB
cord-022353-q2k2krnm	87	9	the	the	DT
cord-022353-q2k2krnm	87	10	deleted	delete	VBN
cord-022353-q2k2krnm	87	11	gene	gene	NN
cord-022353-q2k2krnm	87	12	was	be	VBD
cord-022353-q2k2krnm	87	13	known	know	VBN
cord-022353-q2k2krnm	87	14	to	to	TO
cord-022353-q2k2krnm	87	15	produce	produce	VB
cord-022353-q2k2krnm	87	16	a	a	DT
cord-022353-q2k2krnm	87	17	novel	novel	JJ
cord-022353-q2k2krnm	87	18	target	target	NN
cord-022353-q2k2krnm	87	19	for	for	IN
cord-022353-q2k2krnm	87	20	each	each	DT
cord-022353-q2k2krnm	87	21	of	of	IN
cord-022353-q2k2krnm	87	22	the	the	DT
cord-022353-q2k2krnm	87	23	24	24	CD
cord-022353-q2k2krnm	87	24	new	new	JJ
cord-022353-q2k2krnm	87	25	drugs	drug	NNS
cord-022353-q2k2krnm	87	26	in	in	IN
cord-022353-q2k2krnm	87	27	the	the	DT
cord-022353-q2k2krnm	87	28	developmental	developmental	JJ
cord-022353-q2k2krnm	87	29	pipeline	pipeline	NN
cord-022353-q2k2krnm	87	30	of	of	IN
cord-022353-q2k2krnm	87	31	the	the	DT
cord-022353-q2k2krnm	87	32	10	10	CD
cord-022353-q2k2krnm	87	33	largest	large	JJS
cord-022353-q2k2krnm	87	34	pharmaceutical	pharmaceutical	JJ
cord-022353-q2k2krnm	87	35	companies	company	NNS
cord-022353-q2k2krnm	87	36	,	,	,
cord-022353-q2k2krnm	87	37	and	and	CC
cord-022353-q2k2krnm	87	38	found	find	VBD
cord-022353-q2k2krnm	87	39	that	that	IN
cord-022353-q2k2krnm	87	40	85	85	CD
cord-022353-q2k2krnm	87	41	%	%	NN
cord-022353-q2k2krnm	87	42	of	of	IN
cord-022353-q2k2krnm	87	43	these	these	DT
cord-022353-q2k2krnm	87	44	targets	target	NNS
cord-022353-q2k2krnm	87	45	demonstrated	demonstrate	VBD
cord-022353-q2k2krnm	87	46	a	a	DT
cord-022353-q2k2krnm	87	47	sound	sound	JJ
cord-022353-q2k2krnm	87	48	biologic	biologic	JJ
cord-022353-q2k2krnm	87	49	rationale	rationale	NN
cord-022353-q2k2krnm	87	50	for	for	IN
cord-022353-q2k2krnm	87	51	the	the	DT
cord-022353-q2k2krnm	87	52	selected	select	VBN
cord-022353-q2k2krnm	87	53	disease	disease	NN
cord-022353-q2k2krnm	87	54	.	.	.
cord-022353-q2k2krnm	88	1	Transgenic	transgenic	JJ
cord-022353-q2k2krnm	88	2	and	and	CC
cord-022353-q2k2krnm	88	3	KO	KO	NNP
cord-022353-q2k2krnm	88	4	mice	mouse	NNS
cord-022353-q2k2krnm	88	5	have	have	VBP
cord-022353-q2k2krnm	88	6	been	be	VBN
cord-022353-q2k2krnm	88	7	used	use	VBN
cord-022353-q2k2krnm	88	8	successfully	successfully	RB
cord-022353-q2k2krnm	88	9	to	to	TO
cord-022353-q2k2krnm	88	10	screen	screen	VB
cord-022353-q2k2krnm	88	11	new	new	JJ
cord-022353-q2k2krnm	88	12	drug	drug	NN
cord-022353-q2k2krnm	88	13	candidates	candidate	NNS
cord-022353-q2k2krnm	88	14	for	for	IN
cord-022353-q2k2krnm	88	15	safety	safety	NN
cord-022353-q2k2krnm	88	16	and	and	CC
cord-022353-q2k2krnm	88	17	to	to	TO
cord-022353-q2k2krnm	88	18	elucidate	elucidate	VB
cord-022353-q2k2krnm	88	19	basic	basic	JJ
cord-022353-q2k2krnm	88	20	mechanisms	mechanism	NNS
cord-022353-q2k2krnm	88	21	of	of	IN
cord-022353-q2k2krnm	88	22	toxicity	toxicity	NN
cord-022353-q2k2krnm	88	23	.	.	.
cord-022353-q2k2krnm	89	1	A	a	DT
cord-022353-q2k2krnm	89	2	large	large	JJ
cord-022353-q2k2krnm	89	3	number	number	NN
cord-022353-q2k2krnm	89	4	of	of	IN
cord-022353-q2k2krnm	89	5	drug	drug	NN
cord-022353-q2k2krnm	89	6	metabolizing	metabolizing	NN
cord-022353-q2k2krnm	89	7	enzyme	enzyme	NN
cord-022353-q2k2krnm	89	8	(	(	-LRB-
cord-022353-q2k2krnm	89	9	DME	DME	NNP
cord-022353-q2k2krnm	89	10	)	)	-RRB-
cord-022353-q2k2krnm	89	11	KO	KO	NNP
cord-022353-q2k2krnm	89	12	lines	line	NNS
cord-022353-q2k2krnm	89	13	have	have	VBP
cord-022353-q2k2krnm	89	14	been	be	VBN
cord-022353-q2k2krnm	89	15	employed	employ	VBN
cord-022353-q2k2krnm	89	16	in	in	IN
cord-022353-q2k2krnm	89	17	safety	safety	NN
cord-022353-q2k2krnm	89	18	screening	screening	NN
cord-022353-q2k2krnm	89	19	.	.	.
cord-022353-q2k2krnm	90	1	DMEs	DMEs	NNP
cord-022353-q2k2krnm	90	2	may	may	MD
cord-022353-q2k2krnm	90	3	be	be	VB
cord-022353-q2k2krnm	90	4	involved	involve	VBN
cord-022353-q2k2krnm	90	5	in	in	IN
cord-022353-q2k2krnm	90	6	the	the	DT
cord-022353-q2k2krnm	90	7	safe	safe	JJ
cord-022353-q2k2krnm	90	8	metabolism	metabolism	NN
cord-022353-q2k2krnm	90	9	of	of	IN
cord-022353-q2k2krnm	90	10	a	a	DT
cord-022353-q2k2krnm	90	11	drug	drug	NN
cord-022353-q2k2krnm	90	12	or	or	CC
cord-022353-q2k2krnm	90	13	they	-PRON-	PRP
cord-022353-q2k2krnm	90	14	may	may	MD
cord-022353-q2k2krnm	90	15	generate	generate	VB
cord-022353-q2k2krnm	90	16	toxic	toxic	JJ
cord-022353-q2k2krnm	90	17	intermediates	intermediate	NNS
cord-022353-q2k2krnm	90	18	.	.	.
cord-022353-q2k2krnm	91	1	Removal	removal	NN
cord-022353-q2k2krnm	91	2	of	of	IN
cord-022353-q2k2krnm	91	3	the	the	DT
cord-022353-q2k2krnm	91	4	DME	DME	NNP
cord-022353-q2k2krnm	91	5	gene	gene	NN
cord-022353-q2k2krnm	91	6	may	may	MD
cord-022353-q2k2krnm	91	7	result	result	VB
cord-022353-q2k2krnm	91	8	in	in	IN
cord-022353-q2k2krnm	91	9	the	the	DT
cord-022353-q2k2krnm	91	10	animal	animal	NN
cord-022353-q2k2krnm	91	11	being	be	VBG
cord-022353-q2k2krnm	91	12	more	more	RBR
cord-022353-q2k2krnm	91	13	sensitive	sensitive	JJ
cord-022353-q2k2krnm	91	14	to	to	IN
cord-022353-q2k2krnm	91	15	the	the	DT
cord-022353-q2k2krnm	91	16	test	test	NN
cord-022353-q2k2krnm	91	17	article	article	NN
cord-022353-q2k2krnm	91	18	,	,	,
cord-022353-q2k2krnm	91	19	and	and	CC
cord-022353-q2k2krnm	91	20	it	-PRON-	PRP
cord-022353-q2k2krnm	91	21	may	may	MD
cord-022353-q2k2krnm	91	22	provide	provide	VB
cord-022353-q2k2krnm	91	23	protection	protection	NN
cord-022353-q2k2krnm	91	24	against	against	IN
cord-022353-q2k2krnm	91	25	toxic	toxic	JJ
cord-022353-q2k2krnm	91	26	effects	effect	NNS
cord-022353-q2k2krnm	91	27	of	of	IN
cord-022353-q2k2krnm	91	28	the	the	DT
cord-022353-q2k2krnm	91	29	drug	drug	NN
cord-022353-q2k2krnm	91	30	.	.	.
cord-022353-q2k2krnm	92	1	For	for	IN
cord-022353-q2k2krnm	92	2	instance	instance	NN
cord-022353-q2k2krnm	92	3	,	,	,
cord-022353-q2k2krnm	92	4	KO	KO	NNP
cord-022353-q2k2krnm	92	5	mice	mouse	NNS
cord-022353-q2k2krnm	92	6	lacking	lack	VBG
cord-022353-q2k2krnm	92	7	the	the	DT
cord-022353-q2k2krnm	92	8	NQO-1	NQO-1	NNP
cord-022353-q2k2krnm	92	9	gene	gene	NN
cord-022353-q2k2krnm	92	10	have	have	VBP
cord-022353-q2k2krnm	92	11	increased	increase	VBN
cord-022353-q2k2krnm	92	12	menadione	menadione	NN
cord-022353-q2k2krnm	92	13	toxicity	toxicity	NN
cord-022353-q2k2krnm	92	14	,	,	,
cord-022353-q2k2krnm	92	15	and	and	CC
cord-022353-q2k2krnm	92	16	mice	mouse	NNS
cord-022353-q2k2krnm	92	17	lacking	lack	VBG
cord-022353-q2k2krnm	92	18	the	the	DT
cord-022353-q2k2krnm	92	19	CYP2E1	CYP2E1	NNP
cord-022353-q2k2krnm	92	20	gene	gene	NN
cord-022353-q2k2krnm	92	21	are	be	VBP
cord-022353-q2k2krnm	92	22	resistant	resistant	JJ
cord-022353-q2k2krnm	92	23	to	to	IN
cord-022353-q2k2krnm	92	24	acetaminophen	acetaminophen	NN
cord-022353-q2k2krnm	92	25	hepatotoxicity	hepatotoxicity	NN
cord-022353-q2k2krnm	92	26	(	(	-LRB-
cord-022353-q2k2krnm	92	27	Henderson	Henderson	NNP
cord-022353-q2k2krnm	92	28	and	and	CC
cord-022353-q2k2krnm	92	29	Wolf	Wolf	NNP
cord-022353-q2k2krnm	92	30	2003	2003	CD
cord-022353-q2k2krnm	92	31	)	)	-RRB-
cord-022353-q2k2krnm	92	32	.	.	.
cord-022353-q2k2krnm	93	1	Murine	murine	JJ
cord-022353-q2k2krnm	93	2	models	model	NNS
cord-022353-q2k2krnm	93	3	are	be	VBP
cord-022353-q2k2krnm	93	4	also	also	RB
cord-022353-q2k2krnm	93	5	available	available	JJ
cord-022353-q2k2krnm	93	6	for	for	IN
cord-022353-q2k2krnm	93	7	evaluation	evaluation	NN
cord-022353-q2k2krnm	93	8	of	of	IN
cord-022353-q2k2krnm	93	9	chemical	chemical	JJ
cord-022353-q2k2krnm	93	10	mutagenicity	mutagenicity	NN
cord-022353-q2k2krnm	93	11	(	(	-LRB-
cord-022353-q2k2krnm	93	12	Big	Big	NNP
cord-022353-q2k2krnm	93	13	Blue	Blue	NNP
cord-022353-q2k2krnm	93	14	Mouse	mouse	NN
cord-022353-q2k2krnm	93	15	;	;	:
cord-022353-q2k2krnm	93	16	Stratagene	Stratagene	NNP
cord-022353-q2k2krnm	93	17	,	,	,
cord-022353-q2k2krnm	93	18	La	La	NNP
cord-022353-q2k2krnm	93	19	Jolla	Jolla	NNP
cord-022353-q2k2krnm	93	20	,	,	,
cord-022353-q2k2krnm	93	21	CA	CA	NNP
cord-022353-q2k2krnm	93	22	and	and	CC
cord-022353-q2k2krnm	93	23	Muta	Muta	NNP
cord-022353-q2k2krnm	93	24	Mouse	Mouse	NNP
cord-022353-q2k2krnm	93	25	;	;	:
cord-022353-q2k2krnm	93	26	Covance	Covance	NNP
cord-022353-q2k2krnm	93	27	Research	Research	NNP
cord-022353-q2k2krnm	93	28	Products	Products	NNPS
cord-022353-q2k2krnm	93	29	,	,	,
cord-022353-q2k2krnm	93	30	Denver	Denver	NNP
cord-022353-q2k2krnm	93	31	,	,	,
cord-022353-q2k2krnm	93	32	PA	PA	NNP
cord-022353-q2k2krnm	93	33	)	)	-RRB-
cord-022353-q2k2krnm	93	34	.	.	.
cord-022353-q2k2krnm	94	1	These	these	DT
cord-022353-q2k2krnm	94	2	marker	marker	NN
cord-022353-q2k2krnm	94	3	genes	gene	NNS
cord-022353-q2k2krnm	94	4	are	be	VBP
cord-022353-q2k2krnm	94	5	present	present	JJ
cord-022353-q2k2krnm	94	6	in	in	IN
cord-022353-q2k2krnm	94	7	mice	mouse	NNS
cord-022353-q2k2krnm	94	8	of	of	IN
cord-022353-q2k2krnm	94	9	different	different	JJ
cord-022353-q2k2krnm	94	10	genetic	genetic	JJ
cord-022353-q2k2krnm	94	11	backgrounds	background	NNS
cord-022353-q2k2krnm	94	12	(	(	-LRB-
cord-022353-q2k2krnm	94	13	Bolon	Bolon	NNP
cord-022353-q2k2krnm	94	14	2004	2004	CD
cord-022353-q2k2krnm	94	15	)	)	-RRB-
cord-022353-q2k2krnm	94	16	.	.	.
cord-022353-q2k2krnm	95	1	KO	KO	NNP
cord-022353-q2k2krnm	95	2	lines	line	NNS
cord-022353-q2k2krnm	95	3	have	have	VBP
cord-022353-q2k2krnm	95	4	been	be	VBN
cord-022353-q2k2krnm	95	5	created	create	VBN
cord-022353-q2k2krnm	95	6	with	with	IN
cord-022353-q2k2krnm	95	7	the	the	DT
cord-022353-q2k2krnm	95	8	increased	increase	VBN
cord-022353-q2k2krnm	95	9	sensitivity	sensitivity	NN
cord-022353-q2k2krnm	95	10	to	to	IN
cord-022353-q2k2krnm	95	11	chemically	chemically	RB
cord-022353-q2k2krnm	95	12	induced	induce	VBN
cord-022353-q2k2krnm	95	13	carcinogenesis	carcinogenesis	NN
cord-022353-q2k2krnm	95	14	.	.	.
cord-022353-q2k2krnm	96	1	Mice	mouse	NNS
cord-022353-q2k2krnm	96	2	carrying	carry	VBG
cord-022353-q2k2krnm	96	3	a	a	DT
cord-022353-q2k2krnm	96	4	single	single	JJ
cord-022353-q2k2krnm	96	5	p53	p53	NN
cord-022353-q2k2krnm	96	6	allele	allele	NN
cord-022353-q2k2krnm	96	7	,	,	,
cord-022353-q2k2krnm	96	8	or	or	CC
cord-022353-q2k2krnm	96	9	over	over	IN
cord-022353-q2k2krnm	96	10	expressing	express	VBG
cord-022353-q2k2krnm	96	11	Ha	Ha	NNP
cord-022353-q2k2krnm	96	12	-	-	HYPH
cord-022353-q2k2krnm	96	13	ras	ras	NNP
cord-022353-q2k2krnm	96	14	,	,	,
cord-022353-q2k2krnm	96	15	or	or	CC
cord-022353-q2k2krnm	96	16	having	have	VBG
cord-022353-q2k2krnm	96	17	a	a	DT
cord-022353-q2k2krnm	96	18	complete	complete	JJ
cord-022353-q2k2krnm	96	19	deletion	deletion	NN
cord-022353-q2k2krnm	96	20	of	of	IN
cord-022353-q2k2krnm	96	21	the	the	DT
cord-022353-q2k2krnm	96	22	Xpa	Xpa	NNP
cord-022353-q2k2krnm	96	23	(	(	-LRB-
cord-022353-q2k2krnm	96	24	xeroderma	xeroderma	NNP
cord-022353-q2k2krnm	96	25	pigmentosum	pigmentosum	NNP
cord-022353-q2k2krnm	96	26	)	)	-RRB-
cord-022353-q2k2krnm	96	27	gene	gene	NNP
cord-022353-q2k2krnm	96	28	,	,	,
cord-022353-q2k2krnm	96	29	have	have	VBP
cord-022353-q2k2krnm	96	30	all	all	DT
cord-022353-q2k2krnm	96	31	been	be	VBN
cord-022353-q2k2krnm	96	32	used	use	VBN
cord-022353-q2k2krnm	96	33	for	for	IN
cord-022353-q2k2krnm	96	34	screening	screen	VBG
cord-022353-q2k2krnm	96	35	xenobiotics	xenobiotic	NNS
cord-022353-q2k2krnm	96	36	in	in	IN
cord-022353-q2k2krnm	96	37	vivo	vivo	NN
cord-022353-q2k2krnm	96	38	(	(	-LRB-
cord-022353-q2k2krnm	96	39	Bolon	Bolon	NNP
cord-022353-q2k2krnm	96	40	2004	2004	CD
cord-022353-q2k2krnm	96	41	)	)	-RRB-
cord-022353-q2k2krnm	96	42	.	.	.
cord-022353-q2k2krnm	97	1	These	these	DT
cord-022353-q2k2krnm	97	2	same	same	JJ
cord-022353-q2k2krnm	97	3	transgenic	transgenic	NN
cord-022353-q2k2krnm	97	4	and	and	CC
cord-022353-q2k2krnm	97	5	KO	KO	NNP
cord-022353-q2k2krnm	97	6	models	model	NNS
cord-022353-q2k2krnm	97	7	are	be	VBP
cord-022353-q2k2krnm	97	8	useful	useful	JJ
cord-022353-q2k2krnm	97	9	in	in	IN
cord-022353-q2k2krnm	97	10	screening	screen	VBG
cord-022353-q2k2krnm	97	11	environmental	environmental	JJ
cord-022353-q2k2krnm	97	12	chemicals	chemical	NNS
cord-022353-q2k2krnm	97	13	for	for	IN
cord-022353-q2k2krnm	97	14	toxicities	toxicity	NNS
cord-022353-q2k2krnm	97	15	(	(	-LRB-
cord-022353-q2k2krnm	97	16	Jacobson	Jacobson	NNP
cord-022353-q2k2krnm	97	17	-	-	HYPH
cord-022353-q2k2krnm	97	18	Kram	Kram	NNP
cord-022353-q2k2krnm	97	19	et	et	NNP
cord-022353-q2k2krnm	97	20	al	al	NNP
cord-022353-q2k2krnm	97	21	.	.	.
cord-022353-q2k2krnm	97	22	2004	2004	CD
cord-022353-q2k2krnm	97	23	)	)	-RRB-
cord-022353-q2k2krnm	97	24	.	.	.
cord-022353-q2k2krnm	98	1	It	-PRON-	PRP
cord-022353-q2k2krnm	98	2	is	be	VBZ
cord-022353-q2k2krnm	98	3	clear	clear	JJ
cord-022353-q2k2krnm	98	4	that	that	IN
cord-022353-q2k2krnm	98	5	the	the	DT
cord-022353-q2k2krnm	98	6	mouse	mouse	NN
cord-022353-q2k2krnm	98	7	will	will	MD
cord-022353-q2k2krnm	98	8	continue	continue	VB
cord-022353-q2k2krnm	98	9	to	to	TO
cord-022353-q2k2krnm	98	10	be	be	VB
cord-022353-q2k2krnm	98	11	essential	essential	JJ
cord-022353-q2k2krnm	98	12	for	for	IN
cord-022353-q2k2krnm	98	13	discovery	discovery	NN
cord-022353-q2k2krnm	98	14	and	and	CC
cord-022353-q2k2krnm	98	15	in	in	IN
cord-022353-q2k2krnm	98	16	evaluating	evaluate	VBG
cord-022353-q2k2krnm	98	17	the	the	DT
cord-022353-q2k2krnm	98	18	safety	safety	NN
cord-022353-q2k2krnm	98	19	of	of	IN
cord-022353-q2k2krnm	98	20	new	new	JJ
cord-022353-q2k2krnm	98	21	drugs	drug	NNS
cord-022353-q2k2krnm	98	22	.	.	.
cord-022353-q2k2krnm	99	1	Equally	equally	RB
cord-022353-q2k2krnm	99	2	relevant	relevant	JJ
cord-022353-q2k2krnm	99	3	is	be	VBZ
cord-022353-q2k2krnm	99	4	the	the	DT
cord-022353-q2k2krnm	99	5	development	development	NN
cord-022353-q2k2krnm	99	6	of	of	IN
cord-022353-q2k2krnm	99	7	clinical	clinical	JJ
cord-022353-q2k2krnm	99	8	chemistry	chemistry	NN
cord-022353-q2k2krnm	99	9	assays	assay	NNS
cord-022353-q2k2krnm	99	10	needed	need	VBN
cord-022353-q2k2krnm	99	11	to	to	TO
cord-022353-q2k2krnm	99	12	study	study	VB
cord-022353-q2k2krnm	99	13	the	the	DT
cord-022353-q2k2krnm	99	14	associated	associate	VBN
cord-022353-q2k2krnm	99	15	metabolic	metabolic	JJ
cord-022353-q2k2krnm	99	16	events	event	NNS
cord-022353-q2k2krnm	99	17	in	in	IN
cord-022353-q2k2krnm	99	18	mice	mouse	NNS
cord-022353-q2k2krnm	99	19	(	(	-LRB-
cord-022353-q2k2krnm	99	20	especially	especially	RB
cord-022353-q2k2krnm	99	21	in	in	IN
cord-022353-q2k2krnm	99	22	transgenic	transgenic	JJ
cord-022353-q2k2krnm	99	23	and	and	CC
cord-022353-q2k2krnm	99	24	KO	KO	NNP
cord-022353-q2k2krnm	99	25	lines	line	NNS
cord-022353-q2k2krnm	99	26	)	)	-RRB-
cord-022353-q2k2krnm	99	27	and	and	CC
cord-022353-q2k2krnm	99	28	assess	assess	VB
cord-022353-q2k2krnm	99	29	serum	serum	NN
cord-022353-q2k2krnm	99	30	/	/	SYM
cord-022353-q2k2krnm	99	31	plasma	plasma	NN
cord-022353-q2k2krnm	99	32	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	99	33	.	.	.
cord-022353-q2k2krnm	100	1	These	these	DT
cord-022353-q2k2krnm	100	2	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	100	3	should	should	MD
cord-022353-q2k2krnm	100	4	either	either	CC
cord-022353-q2k2krnm	100	5	be	be	VB
cord-022353-q2k2krnm	100	6	quantitative	quantitative	JJ
cord-022353-q2k2krnm	100	7	measures	measure	NNS
cord-022353-q2k2krnm	100	8	of	of	IN
cord-022353-q2k2krnm	100	9	the	the	DT
cord-022353-q2k2krnm	100	10	biologic	biologic	JJ
cord-022353-q2k2krnm	100	11	effects	effect	NNS
cord-022353-q2k2krnm	100	12	(	(	-LRB-
cord-022353-q2k2krnm	100	13	which	which	WDT
cord-022353-q2k2krnm	100	14	provide	provide	VBP
cord-022353-q2k2krnm	100	15	informative	informative	JJ
cord-022353-q2k2krnm	100	16	links	link	NNS
cord-022353-q2k2krnm	100	17	between	between	IN
cord-022353-q2k2krnm	100	18	mechanism	mechanism	NN
cord-022353-q2k2krnm	100	19	of	of	IN
cord-022353-q2k2krnm	100	20	action	action	NN
cord-022353-q2k2krnm	100	21	and	and	CC
cord-022353-q2k2krnm	100	22	clinical	clinical	JJ
cord-022353-q2k2krnm	100	23	effectiveness	effectiveness	NN
cord-022353-q2k2krnm	100	24	)	)	-RRB-
cord-022353-q2k2krnm	100	25	or	or	CC
cord-022353-q2k2krnm	100	26	surrogate	surrogate	JJ
cord-022353-q2k2krnm	100	27	markers	marker	NNS
cord-022353-q2k2krnm	100	28	(	(	-LRB-
cord-022353-q2k2krnm	100	29	which	which	WDT
cord-022353-q2k2krnm	100	30	are	be	VBP
cord-022353-q2k2krnm	100	31	quantitative	quantitative	JJ
cord-022353-q2k2krnm	100	32	measures	measure	NNS
cord-022353-q2k2krnm	100	33	that	that	WDT
cord-022353-q2k2krnm	100	34	predict	predict	VBP
cord-022353-q2k2krnm	100	35	effectiveness	effectiveness	NN
cord-022353-q2k2krnm	100	36	)	)	-RRB-
cord-022353-q2k2krnm	100	37	.	.	.
cord-022353-q2k2krnm	101	1	In	in	IN
cord-022353-q2k2krnm	101	2	this	this	DT
cord-022353-q2k2krnm	101	3	arena	arena	NN
cord-022353-q2k2krnm	101	4	,	,	,
cord-022353-q2k2krnm	101	5	the	the	DT
cord-022353-q2k2krnm	101	6	field	field	NN
cord-022353-q2k2krnm	101	7	of	of	IN
cord-022353-q2k2krnm	101	8	proteomics	proteomic	NNS
cord-022353-q2k2krnm	101	9	is	be	VBZ
cord-022353-q2k2krnm	101	10	likely	likely	JJ
cord-022353-q2k2krnm	101	11	to	to	TO
cord-022353-q2k2krnm	101	12	make	make	VB
cord-022353-q2k2krnm	101	13	a	a	DT
cord-022353-q2k2krnm	101	14	dramatic	dramatic	JJ
cord-022353-q2k2krnm	101	15	impact	impact	NN
cord-022353-q2k2krnm	101	16	on	on	IN
cord-022353-q2k2krnm	101	17	clinical	clinical	JJ
cord-022353-q2k2krnm	101	18	chemistry	chemistry	NN
cord-022353-q2k2krnm	101	19	.	.	.
cord-022353-q2k2krnm	102	1	Although	although	IN
cord-022353-q2k2krnm	102	2	we	-PRON-	PRP
cord-022353-q2k2krnm	102	3	hope	hope	VBP
cord-022353-q2k2krnm	102	4	all	all	DT
cord-022353-q2k2krnm	102	5	readers	reader	NNS
cord-022353-q2k2krnm	102	6	of	of	IN
cord-022353-q2k2krnm	102	7	this	this	DT
cord-022353-q2k2krnm	102	8	chapter	chapter	NN
cord-022353-q2k2krnm	102	9	will	will	MD
cord-022353-q2k2krnm	102	10	benefit	benefit	VB
cord-022353-q2k2krnm	102	11	from	from	IN
cord-022353-q2k2krnm	102	12	this	this	DT
cord-022353-q2k2krnm	102	13	section	section	NN
cord-022353-q2k2krnm	102	14	on	on	IN
cord-022353-q2k2krnm	102	15	assays	assay	NNS
cord-022353-q2k2krnm	102	16	and	and	CC
cord-022353-q2k2krnm	102	17	instruments	instrument	NNS
cord-022353-q2k2krnm	102	18	,	,	,
cord-022353-q2k2krnm	102	19	the	the	DT
cord-022353-q2k2krnm	102	20	primary	primary	JJ
cord-022353-q2k2krnm	102	21	purpose	purpose	NN
cord-022353-q2k2krnm	102	22	of	of	IN
cord-022353-q2k2krnm	102	23	this	this	DT
cord-022353-q2k2krnm	102	24	chapter	chapter	NN
cord-022353-q2k2krnm	102	25	is	be	VBZ
cord-022353-q2k2krnm	102	26	to	to	TO
cord-022353-q2k2krnm	102	27	briefly	briefly	RB
cord-022353-q2k2krnm	102	28	introduce	introduce	VB
cord-022353-q2k2krnm	102	29	the	the	DT
cord-022353-q2k2krnm	102	30	reader	reader	NN
cord-022353-q2k2krnm	102	31	to	to	IN
cord-022353-q2k2krnm	102	32	areas	area	NNS
cord-022353-q2k2krnm	102	33	where	where	WRB
cord-022353-q2k2krnm	102	34	methods	method	NNS
cord-022353-q2k2krnm	102	35	in	in	IN
cord-022353-q2k2krnm	102	36	clinical	clinical	JJ
cord-022353-q2k2krnm	102	37	chemistry	chemistry	NN
cord-022353-q2k2krnm	102	38	are	be	VBP
cord-022353-q2k2krnm	102	39	changing	change	VBG
cord-022353-q2k2krnm	102	40	and	and	CC
cord-022353-q2k2krnm	102	41	provide	provide	VB
cord-022353-q2k2krnm	102	42	sources	source	NNS
cord-022353-q2k2krnm	102	43	of	of	IN
cord-022353-q2k2krnm	102	44	information	information	NN
cord-022353-q2k2krnm	102	45	for	for	IN
cord-022353-q2k2krnm	102	46	services	service	NNS
cord-022353-q2k2krnm	102	47	,	,	,
cord-022353-q2k2krnm	102	48	reagents	reagent	NNS
cord-022353-q2k2krnm	102	49	(	(	-LRB-
cord-022353-q2k2krnm	102	50	including	include	VBG
cord-022353-q2k2krnm	102	51	test	test	NN
cord-022353-q2k2krnm	102	52	kits	kit	NNS
cord-022353-q2k2krnm	102	53	)	)	-RRB-
cord-022353-q2k2krnm	102	54	,	,	,
cord-022353-q2k2krnm	102	55	and	and	CC
cord-022353-q2k2krnm	102	56	instrumentation	instrumentation	NN
cord-022353-q2k2krnm	102	57	,	,	,
cord-022353-q2k2krnm	102	58	specifically	specifically	RB
cord-022353-q2k2krnm	102	59	for	for	IN
cord-022353-q2k2krnm	102	60	testing	test	VBG
cord-022353-q2k2krnm	102	61	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	102	62	(	(	-LRB-
cord-022353-q2k2krnm	102	63	including	include	VBG
cord-022353-q2k2krnm	102	64	traditional	traditional	JJ
cord-022353-q2k2krnm	102	65	analytes	analyte	NNS
cord-022353-q2k2krnm	102	66	)	)	-RRB-
cord-022353-q2k2krnm	102	67	in	in	IN
cord-022353-q2k2krnm	102	68	mouse	mouse	NN
cord-022353-q2k2krnm	102	69	serum	serum	NN
cord-022353-q2k2krnm	102	70	,	,	,
cord-022353-q2k2krnm	102	71	plasma	plasma	NN
cord-022353-q2k2krnm	102	72	,	,	,
cord-022353-q2k2krnm	102	73	or	or	CC
cord-022353-q2k2krnm	102	74	urine	urine	NN
cord-022353-q2k2krnm	102	75	.	.	.
cord-022353-q2k2krnm	103	1	Those	those	DT
cord-022353-q2k2krnm	103	2	seeking	seek	VBG
cord-022353-q2k2krnm	103	3	a	a	DT
cord-022353-q2k2krnm	103	4	detailed	detailed	JJ
cord-022353-q2k2krnm	103	5	description	description	NN
cord-022353-q2k2krnm	103	6	of	of	IN
cord-022353-q2k2krnm	103	7	clinical	clinical	JJ
cord-022353-q2k2krnm	103	8	chemistry	chemistry	NN
cord-022353-q2k2krnm	103	9	methods	method	NNS
cord-022353-q2k2krnm	103	10	and	and	CC
cord-022353-q2k2krnm	103	11	instruments	instrument	NNS
cord-022353-q2k2krnm	103	12	should	should	MD
cord-022353-q2k2krnm	103	13	refer	refer	VB
cord-022353-q2k2krnm	103	14	to	to	IN
cord-022353-q2k2krnm	103	15	The	the	DT
cord-022353-q2k2krnm	103	16	Fundamentals	Fundamentals	NNPS
cord-022353-q2k2krnm	103	17	of	of	IN
cord-022353-q2k2krnm	103	18	Clinical	Clinical	NNP
cord-022353-q2k2krnm	103	19	Chemistry	Chemistry	NNP
cord-022353-q2k2krnm	103	20	(	(	-LRB-
cord-022353-q2k2krnm	103	21	Burtis	Burtis	NNP
cord-022353-q2k2krnm	103	22	and	and	CC
cord-022353-q2k2krnm	103	23	Ashwood	Ashwood	NNP
cord-022353-q2k2krnm	103	24	2001	2001	CD
cord-022353-q2k2krnm	103	25	)	)	-RRB-
cord-022353-q2k2krnm	103	26	.	.	.
cord-022353-q2k2krnm	104	1	Some	some	DT
cord-022353-q2k2krnm	104	2	dramatic	dramatic	JJ
cord-022353-q2k2krnm	104	3	changes	change	NNS
cord-022353-q2k2krnm	104	4	have	have	VBP
cord-022353-q2k2krnm	104	5	occurred	occur	VBN
cord-022353-q2k2krnm	104	6	over	over	IN
cord-022353-q2k2krnm	104	7	the	the	DT
cord-022353-q2k2krnm	104	8	past	past	JJ
cord-022353-q2k2krnm	104	9	two	two	CD
cord-022353-q2k2krnm	104	10	decades	decade	NNS
cord-022353-q2k2krnm	104	11	that	that	WDT
cord-022353-q2k2krnm	104	12	have	have	VBP
cord-022353-q2k2krnm	104	13	revolutionized	revolutionize	VBN
cord-022353-q2k2krnm	104	14	the	the	DT
cord-022353-q2k2krnm	104	15	discipline	discipline	NN
cord-022353-q2k2krnm	104	16	of	of	IN
cord-022353-q2k2krnm	104	17	clinical	clinical	JJ
cord-022353-q2k2krnm	104	18	chemistry	chemistry	NN
cord-022353-q2k2krnm	104	19	.	.	.
cord-022353-q2k2krnm	105	1	Historically	historically	RB
cord-022353-q2k2krnm	105	2	,	,	,
cord-022353-q2k2krnm	105	3	most	most	JJS
cord-022353-q2k2krnm	105	4	analytes	analyte	NNS
cord-022353-q2k2krnm	105	5	were	be	VBD
cord-022353-q2k2krnm	105	6	measured	measure	VBN
cord-022353-q2k2krnm	105	7	by	by	IN
cord-022353-q2k2krnm	105	8	a	a	DT
cord-022353-q2k2krnm	105	9	colorimetric	colorimetric	JJ
cord-022353-q2k2krnm	105	10	end	end	NN
cord-022353-q2k2krnm	105	11	point	point	NN
cord-022353-q2k2krnm	105	12	assay	assay	NN
cord-022353-q2k2krnm	105	13	(	(	-LRB-
cord-022353-q2k2krnm	105	14	based	base	VBN
cord-022353-q2k2krnm	105	15	on	on	IN
cord-022353-q2k2krnm	105	16	the	the	DT
cord-022353-q2k2krnm	105	17	binding	binding	NN
cord-022353-q2k2krnm	105	18	of	of	IN
cord-022353-q2k2krnm	105	19	an	an	DT
cord-022353-q2k2krnm	105	20	analyte	analyte	NN
cord-022353-q2k2krnm	105	21	to	to	IN
cord-022353-q2k2krnm	105	22	another	another	DT
cord-022353-q2k2krnm	105	23	molecule	molecule	NN
cord-022353-q2k2krnm	105	24	creating	create	VBG
cord-022353-q2k2krnm	105	25	a	a	DT
cord-022353-q2k2krnm	105	26	new	new	JJ
cord-022353-q2k2krnm	105	27	substance	substance	NN
cord-022353-q2k2krnm	105	28	that	that	WDT
cord-022353-q2k2krnm	105	29	absorbs	absorb	VBZ
cord-022353-q2k2krnm	105	30	light	light	NN
cord-022353-q2k2krnm	105	31	of	of	IN
cord-022353-q2k2krnm	105	32	a	a	DT
cord-022353-q2k2krnm	105	33	specific	specific	JJ
cord-022353-q2k2krnm	105	34	wavelength	wavelength	NN
cord-022353-q2k2krnm	105	35	)	)	-RRB-
cord-022353-q2k2krnm	105	36	.	.	.
cord-022353-q2k2krnm	106	1	Some	some	DT
cord-022353-q2k2krnm	106	2	of	of	IN
cord-022353-q2k2krnm	106	3	these	these	DT
cord-022353-q2k2krnm	106	4	analytes	analyte	NNS
cord-022353-q2k2krnm	106	5	and	and	CC
cord-022353-q2k2krnm	106	6	the	the	DT
cord-022353-q2k2krnm	106	7	newer	new	JJR
cord-022353-q2k2krnm	106	8	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	106	9	are	be	VBP
cord-022353-q2k2krnm	106	10	now	now	RB
cord-022353-q2k2krnm	106	11	measured	measure	VBN
cord-022353-q2k2krnm	106	12	by	by	IN
cord-022353-q2k2krnm	106	13	enzymatic	enzymatic	JJ
cord-022353-q2k2krnm	106	14	tests	test	NNS
cord-022353-q2k2krnm	106	15	that	that	WDT
cord-022353-q2k2krnm	106	16	have	have	VBP
cord-022353-q2k2krnm	106	17	higher	high	JJR
cord-022353-q2k2krnm	106	18	specificities	specificity	NNS
cord-022353-q2k2krnm	106	19	and	and	CC
cord-022353-q2k2krnm	106	20	sensitivities	sensitivity	NNS
cord-022353-q2k2krnm	106	21	.	.	.
cord-022353-q2k2krnm	107	1	Another	another	DT
cord-022353-q2k2krnm	107	2	change	change	NN
cord-022353-q2k2krnm	107	3	has	have	VBZ
cord-022353-q2k2krnm	107	4	been	be	VBN
cord-022353-q2k2krnm	107	5	the	the	DT
cord-022353-q2k2krnm	107	6	substitution	substitution	NN
cord-022353-q2k2krnm	107	7	of	of	IN
cord-022353-q2k2krnm	107	8	electrochemical	electrochemical	JJ
cord-022353-q2k2krnm	107	9	assays	assay	NNS
cord-022353-q2k2krnm	107	10	,	,	,
cord-022353-q2k2krnm	107	11	such	such	JJ
cord-022353-q2k2krnm	107	12	as	as	IN
cord-022353-q2k2krnm	107	13	ion	ion	NN
cord-022353-q2k2krnm	107	14	-	-	HYPH
cord-022353-q2k2krnm	107	15	selective	selective	JJ
cord-022353-q2k2krnm	107	16	electrodes	electrode	NNS
cord-022353-q2k2krnm	107	17	,	,	,
cord-022353-q2k2krnm	107	18	for	for	IN
cord-022353-q2k2krnm	107	19	flame	flame	NN
cord-022353-q2k2krnm	107	20	photometry	photometry	NN
cord-022353-q2k2krnm	107	21	used	use	VBN
cord-022353-q2k2krnm	107	22	in	in	IN
cord-022353-q2k2krnm	107	23	the	the	DT
cord-022353-q2k2krnm	107	24	quantitation	quantitation	NN
cord-022353-q2k2krnm	107	25	of	of	IN
cord-022353-q2k2krnm	107	26	sodium	sodium	NN
cord-022353-q2k2krnm	107	27	and	and	CC
cord-022353-q2k2krnm	107	28	potassium	potassium	NN
cord-022353-q2k2krnm	107	29	.	.	.
cord-022353-q2k2krnm	108	1	Perhaps	perhaps	RB
cord-022353-q2k2krnm	108	2	the	the	DT
cord-022353-q2k2krnm	108	3	change	change	NN
cord-022353-q2k2krnm	108	4	that	that	WDT
cord-022353-q2k2krnm	108	5	has	have	VBZ
cord-022353-q2k2krnm	108	6	had	have	VBN
cord-022353-q2k2krnm	108	7	the	the	DT
cord-022353-q2k2krnm	108	8	largest	large	JJS
cord-022353-q2k2krnm	108	9	impact	impact	NN
cord-022353-q2k2krnm	108	10	on	on	IN
cord-022353-q2k2krnm	108	11	clinical	clinical	JJ
cord-022353-q2k2krnm	108	12	chemistry	chemistry	NN
cord-022353-q2k2krnm	108	13	is	be	VBZ
cord-022353-q2k2krnm	108	14	the	the	DT
cord-022353-q2k2krnm	108	15	development	development	NN
cord-022353-q2k2krnm	108	16	of	of	IN
cord-022353-q2k2krnm	108	17	monoclonal	monoclonal	JJ
cord-022353-q2k2krnm	108	18	antibodies	antibody	NNS
cord-022353-q2k2krnm	108	19	and	and	CC
cord-022353-q2k2krnm	108	20	their	-PRON-	PRP$
cord-022353-q2k2krnm	108	21	use	use	NN
cord-022353-q2k2krnm	108	22	as	as	IN
cord-022353-q2k2krnm	108	23	reagents	reagent	NNS
cord-022353-q2k2krnm	108	24	in	in	IN
cord-022353-q2k2krnm	108	25	immunoassays	immunoassays	NNP
cord-022353-q2k2krnm	108	26	(	(	-LRB-
cord-022353-q2k2krnm	108	27	to	to	TO
cord-022353-q2k2krnm	108	28	be	be	VB
cord-022353-q2k2krnm	108	29	discussed	discuss	VBN
cord-022353-q2k2krnm	108	30	later	later	RB
cord-022353-q2k2krnm	108	31	)	)	-RRB-
cord-022353-q2k2krnm	108	32	.	.	.
cord-022353-q2k2krnm	109	1	Many	many	JJ
cord-022353-q2k2krnm	109	2	commercial	commercial	JJ
cord-022353-q2k2krnm	109	3	companies	company	NNS
cord-022353-q2k2krnm	109	4	now	now	RB
cord-022353-q2k2krnm	109	5	offer	offer	VBP
cord-022353-q2k2krnm	109	6	services	service	NNS
cord-022353-q2k2krnm	109	7	that	that	WDT
cord-022353-q2k2krnm	109	8	measure	measure	VBP
cord-022353-q2k2krnm	109	9	analytes	analyte	NNS
cord-022353-q2k2krnm	109	10	and	and	CC
cord-022353-q2k2krnm	109	11	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	109	12	in	in	IN
cord-022353-q2k2krnm	109	13	the	the	DT
cord-022353-q2k2krnm	109	14	blood	blood	NN
cord-022353-q2k2krnm	109	15	of	of	IN
cord-022353-q2k2krnm	109	16	mice	mouse	NNS
cord-022353-q2k2krnm	109	17	using	use	VBG
cord-022353-q2k2krnm	109	18	a	a	DT
cord-022353-q2k2krnm	109	19	combination	combination	NN
cord-022353-q2k2krnm	109	20	of	of	IN
cord-022353-q2k2krnm	109	21	colorimetric-	colorimetric-	NN
cord-022353-q2k2krnm	109	22	,	,	,
cord-022353-q2k2krnm	109	23	enzymatic-	enzymatic-	XX
cord-022353-q2k2krnm	109	24	,	,	,
cord-022353-q2k2krnm	109	25	electrochemical-	electrochemical-	JJ
cord-022353-q2k2krnm	109	26	,	,	,
cord-022353-q2k2krnm	109	27	and	and	CC
cord-022353-q2k2krnm	109	28	immunologic	immunologic	RB
cord-022353-q2k2krnm	109	29	-	-	HYPH
cord-022353-q2k2krnm	109	30	based	base	VBN
cord-022353-q2k2krnm	109	31	methods	method	NNS
cord-022353-q2k2krnm	109	32	,	,	,
cord-022353-q2k2krnm	109	33	and	and	CC
cord-022353-q2k2krnm	109	34	many	many	JJ
cord-022353-q2k2krnm	109	35	of	of	IN
cord-022353-q2k2krnm	109	36	the	the	DT
cord-022353-q2k2krnm	109	37	instruments	instrument	NNS
cord-022353-q2k2krnm	109	38	used	use	VBN
cord-022353-q2k2krnm	109	39	are	be	VBP
cord-022353-q2k2krnm	109	40	capable	capable	JJ
cord-022353-q2k2krnm	109	41	of	of	IN
cord-022353-q2k2krnm	109	42	running	run	VBG
cord-022353-q2k2krnm	109	43	multiple	multiple	JJ
cord-022353-q2k2krnm	109	44	assay	assay	NN
cord-022353-q2k2krnm	109	45	types	type	NNS
cord-022353-q2k2krnm	109	46	simultaneously	simultaneously	RB
cord-022353-q2k2krnm	109	47	.	.	.
cord-022353-q2k2krnm	110	1	The	the	DT
cord-022353-q2k2krnm	110	2	use	use	NN
cord-022353-q2k2krnm	110	3	of	of	IN
cord-022353-q2k2krnm	110	4	laboratories	laboratory	NNS
cord-022353-q2k2krnm	110	5	that	that	WDT
cord-022353-q2k2krnm	110	6	offer	offer	VBP
cord-022353-q2k2krnm	110	7	validated	validate	VBN
cord-022353-q2k2krnm	110	8	assays	assay	NNS
cord-022353-q2k2krnm	110	9	specifically	specifically	RB
cord-022353-q2k2krnm	110	10	for	for	IN
cord-022353-q2k2krnm	110	11	mouse	mouse	NN
cord-022353-q2k2krnm	110	12	blood	blood	NN
cord-022353-q2k2krnm	110	13	is	be	VBZ
cord-022353-q2k2krnm	110	14	important	important	JJ
cord-022353-q2k2krnm	110	15	to	to	TO
cord-022353-q2k2krnm	110	16	ensure	ensure	VB
cord-022353-q2k2krnm	110	17	accurate	accurate	JJ
cord-022353-q2k2krnm	110	18	and	and	CC
cord-022353-q2k2krnm	110	19	precise	precise	JJ
cord-022353-q2k2krnm	110	20	results	result	NNS
cord-022353-q2k2krnm	110	21	.	.	.
cord-022353-q2k2krnm	111	1	A	a	DT
cord-022353-q2k2krnm	111	2	summary	summary	NN
cord-022353-q2k2krnm	111	3	of	of	IN
cord-022353-q2k2krnm	111	4	a	a	DT
cord-022353-q2k2krnm	111	5	few	few	JJ
cord-022353-q2k2krnm	111	6	laboratories	laboratory	NNS
cord-022353-q2k2krnm	111	7	that	that	WDT
cord-022353-q2k2krnm	111	8	provide	provide	VBP
cord-022353-q2k2krnm	111	9	validated	validate	VBN
cord-022353-q2k2krnm	111	10	murine	murine	JJ
cord-022353-q2k2krnm	111	11	assays	assay	NNS
cord-022353-q2k2krnm	111	12	is	be	VBZ
cord-022353-q2k2krnm	111	13	presented	present	VBN
cord-022353-q2k2krnm	111	14	in	in	IN
cord-022353-q2k2krnm	111	15	Table	Table	NNP
cord-022353-q2k2krnm	111	16	6	6	CD
cord-022353-q2k2krnm	111	17	-1	-1	NN
cord-022353-q2k2krnm	111	18	.	.	.
cord-022353-q2k2krnm	112	1	The	the	DT
cord-022353-q2k2krnm	112	2	increasing	increase	VBG
cord-022353-q2k2krnm	112	3	availability	availability	NN
cord-022353-q2k2krnm	112	4	of	of	IN
cord-022353-q2k2krnm	112	5	mouse	mouse	NN
cord-022353-q2k2krnm	112	6	-	-	HYPH
cord-022353-q2k2krnm	112	7	specific	specific	JJ
cord-022353-q2k2krnm	112	8	reagents	reagent	NNS
cord-022353-q2k2krnm	112	9	has	have	VBZ
cord-022353-q2k2krnm	112	10	resulted	result	VBN
cord-022353-q2k2krnm	112	11	in	in	IN
cord-022353-q2k2krnm	112	12	many	many	JJ
cord-022353-q2k2krnm	112	13	new	new	JJ
cord-022353-q2k2krnm	112	14	assay	assay	NN
cord-022353-q2k2krnm	112	15	techniques	technique	NNS
cord-022353-q2k2krnm	112	16	that	that	WDT
cord-022353-q2k2krnm	112	17	provide	provide	VBP
cord-022353-q2k2krnm	112	18	a	a	DT
cord-022353-q2k2krnm	112	19	high	high	JJ
cord-022353-q2k2krnm	112	20	degree	degree	NN
cord-022353-q2k2krnm	112	21	of	of	IN
cord-022353-q2k2krnm	112	22	sensitivity	sensitivity	NN
cord-022353-q2k2krnm	112	23	and	and	CC
cord-022353-q2k2krnm	112	24	specificity	specificity	NN
cord-022353-q2k2krnm	112	25	.	.	.
cord-022353-q2k2krnm	113	1	Growth	growth	NN
cord-022353-q2k2krnm	113	2	in	in	IN
cord-022353-q2k2krnm	113	3	the	the	DT
cord-022353-q2k2krnm	113	4	number	number	NN
cord-022353-q2k2krnm	113	5	of	of	IN
cord-022353-q2k2krnm	113	6	reagents	reagent	NNS
cord-022353-q2k2krnm	113	7	capable	capable	JJ
cord-022353-q2k2krnm	113	8	of	of	IN
cord-022353-q2k2krnm	113	9	quantitating	quantitate	VBG
cord-022353-q2k2krnm	113	10	analytes	analyte	NNS
cord-022353-q2k2krnm	113	11	in	in	IN
cord-022353-q2k2krnm	113	12	mouse	mouse	NN
cord-022353-q2k2krnm	113	13	serum	serum	NN
cord-022353-q2k2krnm	113	14	is	be	VBZ
cord-022353-q2k2krnm	113	15	illustrated	illustrate	VBN
cord-022353-q2k2krnm	113	16	in	in	IN
cord-022353-q2k2krnm	113	17	Table	Table	NNP
cord-022353-q2k2krnm	113	18	6	6	CD
cord-022353-q2k2krnm	113	19	-2	-2	CD
cord-022353-q2k2krnm	113	20	.	.	.
cord-022353-q2k2krnm	114	1	Techniques	technique	NNS
cord-022353-q2k2krnm	114	2	employing	employ	VBG
cord-022353-q2k2krnm	114	3	nonisotopic	nonisotopic	JJ
cord-022353-q2k2krnm	114	4	labels	label	NNS
cord-022353-q2k2krnm	114	5	for	for	IN
cord-022353-q2k2krnm	114	6	detection	detection	NN
cord-022353-q2k2krnm	114	7	such	such	JJ
cord-022353-q2k2krnm	114	8	as	as	IN
cord-022353-q2k2krnm	114	9	enzyme	enzyme	NN
cord-022353-q2k2krnm	114	10	cascade	cascade	NN
cord-022353-q2k2krnm	114	11	,	,	,
cord-022353-q2k2krnm	114	12	fluorescence	fluorescence	NN
cord-022353-q2k2krnm	114	13	,	,	,
cord-022353-q2k2krnm	114	14	chemiluminescence	chemiluminescence	NN
cord-022353-q2k2krnm	114	15	,	,	,
cord-022353-q2k2krnm	114	16	and	and	CC
cord-022353-q2k2krnm	114	17	electrochemiluminescence	electrochemiluminescence	NN
cord-022353-q2k2krnm	114	18	,	,	,
cord-022353-q2k2krnm	114	19	are	be	VBP
cord-022353-q2k2krnm	114	20	rapidly	rapidly	RB
cord-022353-q2k2krnm	114	21	replacing	replace	VBG
cord-022353-q2k2krnm	114	22	older	old	JJR
cord-022353-q2k2krnm	114	23	radioimmunoassay	radioimmunoassay	JJ
cord-022353-q2k2krnm	114	24	(	(	-LRB-
cord-022353-q2k2krnm	114	25	RIA	RIA	NNP
cord-022353-q2k2krnm	114	26	)	)	-RRB-
cord-022353-q2k2krnm	114	27	techniques	technique	NNS
cord-022353-q2k2krnm	114	28	.	.	.
cord-022353-q2k2krnm	115	1	Enzyme	Enzyme	NNP
cord-022353-q2k2krnm	115	2	immunoassays	immunoassay	NNS
cord-022353-q2k2krnm	115	3	,	,	,
cord-022353-q2k2krnm	115	4	such	such	JJ
cord-022353-q2k2krnm	115	5	as	as	IN
cord-022353-q2k2krnm	115	6	enzyme	enzyme	NN
cord-022353-q2k2krnm	115	7	-	-	HYPH
cord-022353-q2k2krnm	115	8	linked	link	VBN
cord-022353-q2k2krnm	115	9	immunosorbent	immunosorbent	JJ
cord-022353-q2k2krnm	115	10	assay	assay	NN
cord-022353-q2k2krnm	115	11	(	(	-LRB-
cord-022353-q2k2krnm	115	12	ELISA	ELISA	NNP
cord-022353-q2k2krnm	115	13	)	)	-RRB-
cord-022353-q2k2krnm	115	14	,	,	,
cord-022353-q2k2krnm	115	15	enzyme	enzyme	NN
cord-022353-q2k2krnm	115	16	-	-	HYPH
cord-022353-q2k2krnm	115	17	multiplier	multiplier	NN
cord-022353-q2k2krnm	115	18	immunoassay	immunoassay	JJ
cord-022353-q2k2krnm	115	19	technique	technique	NN
cord-022353-q2k2krnm	115	20	(	(	-LRB-
cord-022353-q2k2krnm	115	21	EMIT	emit	VB
cord-022353-q2k2krnm	115	22	)	)	-RRB-
cord-022353-q2k2krnm	115	23	,	,	,
cord-022353-q2k2krnm	115	24	and	and	CC
cord-022353-q2k2krnm	115	25	cloned	clone	VBN
cord-022353-q2k2krnm	115	26	enzyme	enzyme	NN
cord-022353-q2k2krnm	115	27	donor	donor	NN
cord-022353-q2k2krnm	115	28	immunoassay	immunoassay	NN
cord-022353-q2k2krnm	115	29	(	(	-LRB-
cord-022353-q2k2krnm	115	30	CEDIA	CEDIA	NNP
cord-022353-q2k2krnm	115	31	)	)	-RRB-
cord-022353-q2k2krnm	115	32	,	,	,
cord-022353-q2k2krnm	115	33	provide	provide	VB
cord-022353-q2k2krnm	115	34	quantitative	quantitative	JJ
cord-022353-q2k2krnm	115	35	results	result	NNS
cord-022353-q2k2krnm	115	36	based	base	VBN
cord-022353-q2k2krnm	115	37	on	on	IN
cord-022353-q2k2krnm	115	38	photometric	photometric	JJ
cord-022353-q2k2krnm	115	39	methods	method	NNS
cord-022353-q2k2krnm	115	40	.	.	.
cord-022353-q2k2krnm	116	1	Enzyme	enzyme	NN
cord-022353-q2k2krnm	116	2	immunoassay	immunoassay	NN
cord-022353-q2k2krnm	116	3	is	be	VBZ
cord-022353-q2k2krnm	116	4	popular	popular	JJ
cord-022353-q2k2krnm	116	5	because	because	IN
cord-022353-q2k2krnm	116	6	it	-PRON-	PRP
cord-022353-q2k2krnm	116	7	generates	generate	VBZ
cord-022353-q2k2krnm	116	8	compounds	compound	NNS
cord-022353-q2k2krnm	116	9	that	that	WDT
cord-022353-q2k2krnm	116	10	can	can	MD
cord-022353-q2k2krnm	116	11	be	be	VB
cord-022353-q2k2krnm	116	12	quantitated	quantitated	JJ
cord-022353-q2k2krnm	116	13	photometrically	photometrically	RB
cord-022353-q2k2krnm	116	14	.	.	.
cord-022353-q2k2krnm	117	1	Typical	typical	JJ
cord-022353-q2k2krnm	117	2	enzymatic	enzymatic	JJ
cord-022353-q2k2krnm	117	3	labels	label	NNS
cord-022353-q2k2krnm	117	4	include	include	VBP
cord-022353-q2k2krnm	117	5	~-galactosidase	~-galactosidase	CD
cord-022353-q2k2krnm	117	6	,	,	,
cord-022353-q2k2krnm	117	7	horseradish	horseradish	NN
cord-022353-q2k2krnm	117	8	peroxidase	peroxidase	NN
cord-022353-q2k2krnm	117	9	,	,	,
cord-022353-q2k2krnm	117	10	alkaline	alkaline	JJ
cord-022353-q2k2krnm	117	11	phosphatase	phosphatase	NN
cord-022353-q2k2krnm	117	12	,	,	,
cord-022353-q2k2krnm	117	13	and	and	CC
cord-022353-q2k2krnm	117	14	glucose-6-dehydrogenase	glucose-6-dehydrogenase	NNP
cord-022353-q2k2krnm	117	15	.	.	.
cord-022353-q2k2krnm	118	1	In	in	IN
cord-022353-q2k2krnm	118	2	addition	addition	NN
cord-022353-q2k2krnm	118	3	these	these	DT
cord-022353-q2k2krnm	118	4	ELISA	ELISA	NNP
cord-022353-q2k2krnm	118	5	test	test	NN
cord-022353-q2k2krnm	118	6	kits	kit	NNS
cord-022353-q2k2krnm	118	7	are	be	VBP
cord-022353-q2k2krnm	118	8	compact	compact	JJ
cord-022353-q2k2krnm	118	9	,	,	,
cord-022353-q2k2krnm	118	10	easy	easy	JJ
cord-022353-q2k2krnm	118	11	to	to	TO
cord-022353-q2k2krnm	118	12	use	use	VB
cord-022353-q2k2krnm	118	13	,	,	,
cord-022353-q2k2krnm	118	14	and	and	CC
cord-022353-q2k2krnm	118	15	quantitated	quantitate	VBN
cord-022353-q2k2krnm	118	16	with	with	IN
cord-022353-q2k2krnm	118	17	inexpensive	inexpensive	JJ
cord-022353-q2k2krnm	118	18	instruments	instrument	NNS
cord-022353-q2k2krnm	118	19	.	.	.
cord-022353-q2k2krnm	119	1	These	these	DT
cord-022353-q2k2krnm	119	2	kits	kit	NNS
cord-022353-q2k2krnm	119	3	(	(	-LRB-
cord-022353-q2k2krnm	119	4	usually	usually	RB
cord-022353-q2k2krnm	119	5	in	in	IN
cord-022353-q2k2krnm	119	6	a	a	DT
cord-022353-q2k2krnm	119	7	well	well	JJ
cord-022353-q2k2krnm	119	8	format	format	NN
cord-022353-q2k2krnm	119	9	)	)	-RRB-
cord-022353-q2k2krnm	119	10	are	be	VBP
cord-022353-q2k2krnm	119	11	available	available	JJ
cord-022353-q2k2krnm	119	12	for	for	IN
cord-022353-q2k2krnm	119	13	quantitation	quantitation	NN
cord-022353-q2k2krnm	119	14	of	of	IN
cord-022353-q2k2krnm	119	15	a	a	DT
cord-022353-q2k2krnm	119	16	wide	wide	JJ
cord-022353-q2k2krnm	119	17	range	range	NN
cord-022353-q2k2krnm	119	18	of	of	IN
cord-022353-q2k2krnm	119	19	mouse	mouse	NN
cord-022353-q2k2krnm	119	20	serum	serum	NN
cord-022353-q2k2krnm	119	21	and	and	CC
cord-022353-q2k2krnm	119	22	plasma	plasma	NN
cord-022353-q2k2krnm	119	23	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	119	24	(	(	-LRB-
cord-022353-q2k2krnm	119	25	Table	Table	NNP
cord-022353-q2k2krnm	119	26	6	6	CD
cord-022353-q2k2krnm	119	27	-	-	SYM
cord-022353-q2k2krnm	119	28	3	3	CD
cord-022353-q2k2krnm	119	29	)	)	-RRB-
cord-022353-q2k2krnm	119	30	.	.	.
cord-022353-q2k2krnm	120	1	Fluoroimmunoassay	Fluoroimmunoassay	NNP
cord-022353-q2k2krnm	120	2	(	(	-LRB-
cord-022353-q2k2krnm	120	3	FIA	FIA	NNP
cord-022353-q2k2krnm	120	4	)	)	-RRB-
cord-022353-q2k2krnm	120	5	,	,	,
cord-022353-q2k2krnm	120	6	which	which	WDT
cord-022353-q2k2krnm	120	7	utilizes	utilize	VBZ
cord-022353-q2k2krnm	120	8	a	a	DT
cord-022353-q2k2krnm	120	9	fluorescent	fluorescent	JJ
cord-022353-q2k2krnm	120	10	molecule	molecule	NN
cord-022353-q2k2krnm	120	11	as	as	IN
cord-022353-q2k2krnm	120	12	an	an	DT
cord-022353-q2k2krnm	120	13	indicator	indicator	NN
cord-022353-q2k2krnm	120	14	label	label	NN
cord-022353-q2k2krnm	120	15	,	,	,
cord-022353-q2k2krnm	120	16	was	be	VBD
cord-022353-q2k2krnm	120	17	previously	previously	RB
cord-022353-q2k2krnm	120	18	subject	subject	JJ
cord-022353-q2k2krnm	120	19	to	to	IN
cord-022353-q2k2krnm	120	20	problems	problem	NNS
cord-022353-q2k2krnm	120	21	associated	associate	VBN
cord-022353-q2k2krnm	120	22	with	with	IN
cord-022353-q2k2krnm	120	23	background	background	NN
cord-022353-q2k2krnm	120	24	fluorescence	fluorescence	NN
cord-022353-q2k2krnm	120	25	.	.	.
cord-022353-q2k2krnm	121	1	Today	today	NN
cord-022353-q2k2krnm	121	2	this	this	DT
cord-022353-q2k2krnm	121	3	problem	problem	NN
cord-022353-q2k2krnm	121	4	has	have	VBZ
cord-022353-q2k2krnm	121	5	been	be	VBN
cord-022353-q2k2krnm	121	6	largely	largely	RB
cord-022353-q2k2krnm	121	7	resolved	resolve	VBN
cord-022353-q2k2krnm	121	8	by	by	IN
cord-022353-q2k2krnm	121	9	using	use	VBG
cord-022353-q2k2krnm	121	10	chelates	chelate	NNS
cord-022353-q2k2krnm	121	11	of	of	IN
cord-022353-q2k2krnm	121	12	lanthanide	lanthanide	NNP
cord-022353-q2k2krnm	121	13	as	as	IN
cord-022353-q2k2krnm	121	14	a	a	DT
cord-022353-q2k2krnm	121	15	label	label	NN
cord-022353-q2k2krnm	121	16	.	.	.
cord-022353-q2k2krnm	122	1	Modifications	modification	NNS
cord-022353-q2k2krnm	122	2	of	of	IN
cord-022353-q2k2krnm	122	3	FIA	FIA	NNP
cord-022353-q2k2krnm	122	4	have	have	VBP
cord-022353-q2k2krnm	122	5	eliminated	eliminate	VBN
cord-022353-q2k2krnm	122	6	the	the	DT
cord-022353-q2k2krnm	122	7	need	need	NN
cord-022353-q2k2krnm	122	8	to	to	TO
cord-022353-q2k2krnm	122	9	separate	separate	VB
cord-022353-q2k2krnm	122	10	free	free	JJ
cord-022353-q2k2krnm	122	11	from	from	IN
cord-022353-q2k2krnm	122	12	bound	bound	JJ
cord-022353-q2k2krnm	122	13	label	label	NN
cord-022353-q2k2krnm	122	14	(	(	-LRB-
cord-022353-q2k2krnm	122	15	homogenous	homogenous	JJ
cord-022353-q2k2krnm	122	16	assay	assay	NN
cord-022353-q2k2krnm	122	17	)	)	-RRB-
cord-022353-q2k2krnm	122	18	.	.	.
cord-022353-q2k2krnm	123	1	Chemiluminescent	Chemiluminescent	NNP
cord-022353-q2k2krnm	123	2	and	and	CC
cord-022353-q2k2krnm	123	3	electrochemilumiscent	electrochemilumiscent	NNP
cord-022353-q2k2krnm	123	4	immunoassays	immunoassays	NNP
cord-022353-q2k2krnm	123	5	are	be	VBP
cord-022353-q2k2krnm	123	6	similar	similar	JJ
cord-022353-q2k2krnm	123	7	to	to	IN
cord-022353-q2k2krnm	123	8	enzyme	enzyme	NNP
cord-022353-q2k2krnm	123	9	immunoassays	immunoassays	NNP
cord-022353-q2k2krnm	123	10	,	,	,
cord-022353-q2k2krnm	123	11	except	except	IN
cord-022353-q2k2krnm	123	12	that	that	DT
cord-022353-q2k2krnm	123	13	quantitation	quantitation	NN
cord-022353-q2k2krnm	123	14	of	of	IN
cord-022353-q2k2krnm	123	15	results	result	NNS
cord-022353-q2k2krnm	123	16	is	be	VBZ
cord-022353-q2k2krnm	123	17	based	base	VBN
cord-022353-q2k2krnm	123	18	on	on	IN
cord-022353-q2k2krnm	123	19	the	the	DT
cord-022353-q2k2krnm	123	20	emission	emission	NN
cord-022353-q2k2krnm	123	21	of	of	IN
cord-022353-q2k2krnm	123	22	light	light	NN
cord-022353-q2k2krnm	123	23	after	after	IN
cord-022353-q2k2krnm	123	24	a	a	DT
cord-022353-q2k2krnm	123	25	chemical	chemical	JJ
cord-022353-q2k2krnm	123	26	label	label	NN
cord-022353-q2k2krnm	123	27	is	be	VBZ
cord-022353-q2k2krnm	123	28	exposed	expose	VBN
cord-022353-q2k2krnm	123	29	to	to	IN
cord-022353-q2k2krnm	123	30	an	an	DT
cord-022353-q2k2krnm	123	31	oxidation	oxidation	NN
cord-022353-q2k2krnm	123	32	reaction	reaction	NN
cord-022353-q2k2krnm	123	33	(	(	-LRB-
cord-022353-q2k2krnm	123	34	chemiluminescence	chemiluminescence	NNP
cord-022353-q2k2krnm	123	35	)	)	-RRB-
cord-022353-q2k2krnm	123	36	or	or	CC
cord-022353-q2k2krnm	123	37	to	to	IN
cord-022353-q2k2krnm	123	38	an	an	DT
cord-022353-q2k2krnm	123	39	electrochemical	electrochemical	JJ
cord-022353-q2k2krnm	123	40	reaction	reaction	NN
cord-022353-q2k2krnm	123	41	(	(	-LRB-
cord-022353-q2k2krnm	123	42	electrochemiluminescence	electrochemiluminescence	NNP
cord-022353-q2k2krnm	123	43	)	)	-RRB-
cord-022353-q2k2krnm	123	44	.	.	.
cord-022353-q2k2krnm	124	1	The	the	DT
cord-022353-q2k2krnm	124	2	number	number	NN
cord-022353-q2k2krnm	124	3	of	of	IN
cord-022353-q2k2krnm	124	4	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	124	5	that	that	WDT
cord-022353-q2k2krnm	124	6	can	can	MD
cord-022353-q2k2krnm	124	7	be	be	VB
cord-022353-q2k2krnm	124	8	quantified	quantify	VBN
cord-022353-q2k2krnm	124	9	by	by	IN
cord-022353-q2k2krnm	124	10	commercially	commercially	RB
cord-022353-q2k2krnm	124	11	available	available	JJ
cord-022353-q2k2krnm	124	12	test	test	NN
cord-022353-q2k2krnm	124	13	kits	kit	NNS
cord-022353-q2k2krnm	124	14	based	base	VBN
cord-022353-q2k2krnm	124	15	on	on	IN
cord-022353-q2k2krnm	124	16	immunoassays	immunoassays	NNP
cord-022353-q2k2krnm	124	17	is	be	VBZ
cord-022353-q2k2krnm	124	18	likely	likely	JJ
cord-022353-q2k2krnm	124	19	to	to	TO
cord-022353-q2k2krnm	124	20	grow	grow	VB
cord-022353-q2k2krnm	124	21	at	at	IN
cord-022353-q2k2krnm	124	22	unparalleled	unparalleled	JJ
cord-022353-q2k2krnm	124	23	rates	rate	NNS
cord-022353-q2k2krnm	124	24	as	as	IN
cord-022353-q2k2krnm	124	25	a	a	DT
cord-022353-q2k2krnm	124	26	result	result	NN
cord-022353-q2k2krnm	124	27	of	of	IN
cord-022353-q2k2krnm	124	28	proteomics	proteomic	NNS
cord-022353-q2k2krnm	124	29	research	research	NN
cord-022353-q2k2krnm	124	30	where	where	WRB
cord-022353-q2k2krnm	124	31	mice	mouse	NNS
cord-022353-q2k2krnm	124	32	are	be	VBP
cord-022353-q2k2krnm	124	33	the	the	DT
cord-022353-q2k2krnm	124	34	favored	favor	VBN
cord-022353-q2k2krnm	124	35	model	model	NN
cord-022353-q2k2krnm	124	36	.	.	.
cord-022353-q2k2krnm	125	1	Mulitplex	mulitplex	NN
cord-022353-q2k2krnm	125	2	immunoassay	immunoassay	NN
cord-022353-q2k2krnm	125	3	is	be	VBZ
cord-022353-q2k2krnm	125	4	a	a	DT
cord-022353-q2k2krnm	125	5	unique	unique	JJ
cord-022353-q2k2krnm	125	6	technology	technology	NN
cord-022353-q2k2krnm	125	7	that	that	WDT
cord-022353-q2k2krnm	125	8	combines	combine	VBZ
cord-022353-q2k2krnm	125	9	four	four	CD
cord-022353-q2k2krnm	125	10	distinct	distinct	JJ
cord-022353-q2k2krnm	125	11	components	component	NNS
cord-022353-q2k2krnm	125	12	in	in	IN
cord-022353-q2k2krnm	125	13	a	a	DT
cord-022353-q2k2krnm	125	14	manner	manner	NN
cord-022353-q2k2krnm	125	15	that	that	WDT
cord-022353-q2k2krnm	125	16	allows	allow	VBZ
cord-022353-q2k2krnm	125	17	for	for	IN
cord-022353-q2k2krnm	125	18	simultaneous	simultaneous	JJ
cord-022353-q2k2krnm	125	19	analysis	analysis	NN
cord-022353-q2k2krnm	125	20	of	of	IN
cord-022353-q2k2krnm	125	21	up	up	IN
cord-022353-q2k2krnm	125	22	to	to	TO
cord-022353-q2k2krnm	125	23	90	90	CD
cord-022353-q2k2krnm	125	24	different	different	JJ
cord-022353-q2k2krnm	125	25	analytes	analyte	NNS
cord-022353-q2k2krnm	125	26	from	from	IN
cord-022353-q2k2krnm	125	27	50	50	CD
cord-022353-q2k2krnm	125	28	ktL	ktL	NNS
cord-022353-q2k2krnm	125	29	of	of	IN
cord-022353-q2k2krnm	125	30	serum	serum	NN
cord-022353-q2k2krnm	125	31	/	/	SYM
cord-022353-q2k2krnm	125	32	plasma	plasma	NN
cord-022353-q2k2krnm	125	33	.	.	.
cord-022353-q2k2krnm	126	1	The	the	DT
cord-022353-q2k2krnm	126	2	core	core	NN
cord-022353-q2k2krnm	126	3	component	component	NN
cord-022353-q2k2krnm	126	4	is	be	VBZ
cord-022353-q2k2krnm	126	5	an	an	DT
cord-022353-q2k2krnm	126	6	inexpensive	inexpensive	JJ
cord-022353-q2k2krnm	126	7	,	,	,
cord-022353-q2k2krnm	126	8	consumable	consumable	JJ
cord-022353-q2k2krnm	126	9	,	,	,
cord-022353-q2k2krnm	126	10	5.6	5.6	CD
cord-022353-q2k2krnm	126	11	~tm	~tm	NNP
cord-022353-q2k2krnm	126	12	diameter	diameter	NN
cord-022353-q2k2krnm	126	13	polystyrene	polystyrene	NN
cord-022353-q2k2krnm	126	14	microsphere	microsphere	NN
cord-022353-q2k2krnm	126	15	that	that	WDT
cord-022353-q2k2krnm	126	16	are	be	VBP
cord-022353-q2k2krnm	126	17	encoded	encode	VBN
cord-022353-q2k2krnm	126	18	into	into	IN
cord-022353-q2k2krnm	126	19	100	100	CD
cord-022353-q2k2krnm	126	20	different	different	JJ
cord-022353-q2k2krnm	126	21	fluorescent	fluorescent	NN
cord-022353-q2k2krnm	126	22	color	color	NN
cord-022353-q2k2krnm	126	23	sets	set	NNS
cord-022353-q2k2krnm	126	24	using	use	VBG
cord-022353-q2k2krnm	126	25	two	two	CD
cord-022353-q2k2krnm	126	26	fluorophores	fluorophore	NNS
cord-022353-q2k2krnm	126	27	(	(	-LRB-
cord-022353-q2k2krnm	126	28	red	red	JJ
cord-022353-q2k2krnm	126	29	and	and	CC
cord-022353-q2k2krnm	126	30	infrared	infrared	JJ
cord-022353-q2k2krnm	126	31	)	)	-RRB-
cord-022353-q2k2krnm	126	32	at	at	IN
cord-022353-q2k2krnm	126	33	multiple	multiple	JJ
cord-022353-q2k2krnm	126	34	concentrations	concentration	NNS
cord-022353-q2k2krnm	126	35	.	.	.
cord-022353-q2k2krnm	127	1	The	the	DT
cord-022353-q2k2krnm	127	2	second	second	JJ
cord-022353-q2k2krnm	127	3	component	component	NN
cord-022353-q2k2krnm	127	4	is	be	VBZ
cord-022353-q2k2krnm	127	5	a	a	DT
cord-022353-q2k2krnm	127	6	biologic	biologic	JJ
cord-022353-q2k2krnm	127	7	assay	assay	NN
cord-022353-q2k2krnm	127	8	(	(	-LRB-
cord-022353-q2k2krnm	127	9	combined	combine	VBN
cord-022353-q2k2krnm	127	10	with	with	IN
cord-022353-q2k2krnm	127	11	an	an	DT
cord-022353-q2k2krnm	127	12	 	 	_SP
cord-022353-q2k2krnm	128	1	MMP-3	MMP-3	NNP
cord-022353-q2k2krnm	128	2	(	(	-LRB-
cord-022353-q2k2krnm	128	3	matrix	matrix	NN
cord-022353-q2k2krnm	128	4	metalloproteinases	metalloproteinase	NNS
cord-022353-q2k2krnm	128	5	)	)	-RRB-
cord-022353-q2k2krnm	129	1	Pro	pro	JJ
cord-022353-q2k2krnm	129	2	-	-	JJ
cord-022353-q2k2krnm	129	3	MMP-9	mmp-9	JJ
cord-022353-q2k2krnm	129	4	MMP-9	MMP-9	NNP
cord-022353-q2k2krnm	129	5	Tissue	Tissue	NNP
cord-022353-q2k2krnm	129	6	inhibitor	inhibitor	NN
cord-022353-q2k2krnm	129	7	of	of	IN
cord-022353-q2k2krnm	129	8	metalloprotease	metalloprotease	NNP
cord-022353-q2k2krnm	129	9	1	1	CD
cord-022353-q2k2krnm	129	10	(	(	-LRB-
cord-022353-q2k2krnm	129	11	TIMP-1	TIMP-1	NNP
cord-022353-q2k2krnm	129	12	)	)	-RRB-
cord-022353-q2k2krnm	129	13	orange	orange	JJ
cord-022353-q2k2krnm	129	14	fluorescent	fluorescent	JJ
cord-022353-q2k2krnm	129	15	reporter	reporter	NN
cord-022353-q2k2krnm	129	16	molecule	molecule	NN
cord-022353-q2k2krnm	129	17	)	)	-RRB-
cord-022353-q2k2krnm	129	18	that	that	WDT
cord-022353-q2k2krnm	129	19	is	be	VBZ
cord-022353-q2k2krnm	129	20	built	build	VBN
cord-022353-q2k2krnm	129	21	onto	onto	IN
cord-022353-q2k2krnm	129	22	the	the	DT
cord-022353-q2k2krnm	129	23	surface	surface	NN
cord-022353-q2k2krnm	129	24	of	of	IN
cord-022353-q2k2krnm	129	25	the	the	DT
cord-022353-q2k2krnm	129	26	microspheres	microsphere	NNS
cord-022353-q2k2krnm	129	27	.	.	.
cord-022353-q2k2krnm	130	1	A	a	DT
cord-022353-q2k2krnm	130	2	diverse	diverse	JJ
cord-022353-q2k2krnm	130	3	range	range	NN
cord-022353-q2k2krnm	130	4	of	of	IN
cord-022353-q2k2krnm	130	5	biologic	biologic	JJ
cord-022353-q2k2krnm	130	6	assays	assay	NNS
cord-022353-q2k2krnm	130	7	can	can	MD
cord-022353-q2k2krnm	130	8	be	be	VB
cord-022353-q2k2krnm	130	9	built	build	VBN
cord-022353-q2k2krnm	130	10	onto	onto	IN
cord-022353-q2k2krnm	130	11	the	the	DT
cord-022353-q2k2krnm	130	12	microsphere	microsphere	NN
cord-022353-q2k2krnm	130	13	surface	surface	NN
cord-022353-q2k2krnm	130	14	,	,	,
cord-022353-q2k2krnm	130	15	including	include	VBG
cord-022353-q2k2krnm	130	16	immunoassays	immunoassay	NNS
cord-022353-q2k2krnm	130	17	,	,	,
cord-022353-q2k2krnm	130	18	nucleic	nucleic	JJ
cord-022353-q2k2krnm	130	19	acid	acid	NN
cord-022353-q2k2krnm	130	20	assays	assay	NNS
cord-022353-q2k2krnm	130	21	,	,	,
cord-022353-q2k2krnm	130	22	enzymatic	enzymatic	JJ
cord-022353-q2k2krnm	130	23	reaction	reaction	NN
cord-022353-q2k2krnm	130	24	assays	assay	NNS
cord-022353-q2k2krnm	130	25	,	,	,
cord-022353-q2k2krnm	130	26	or	or	CC
cord-022353-q2k2krnm	130	27	receptor	receptor	NN
cord-022353-q2k2krnm	130	28	-	-	HYPH
cord-022353-q2k2krnm	130	29	ligand	ligand	NN
cord-022353-q2k2krnm	130	30	analysis	analysis	NN
cord-022353-q2k2krnm	130	31	assays	assay	NNS
cord-022353-q2k2krnm	130	32	.	.	.
cord-022353-q2k2krnm	131	1	The	the	DT
cord-022353-q2k2krnm	131	2	third	third	JJ
cord-022353-q2k2krnm	131	3	component	component	NN
cord-022353-q2k2krnm	131	4	is	be	VBZ
cord-022353-q2k2krnm	131	5	a	a	DT
cord-022353-q2k2krnm	131	6	flow	flow	NN
cord-022353-q2k2krnm	131	7	cytometer	cytometer	NN
cord-022353-q2k2krnm	131	8	that	that	WDT
cord-022353-q2k2krnm	131	9	focuses	focus	VBZ
cord-022353-q2k2krnm	131	10	the	the	DT
cord-022353-q2k2krnm	131	11	microspheres	microsphere	NNS
cord-022353-q2k2krnm	131	12	into	into	IN
cord-022353-q2k2krnm	131	13	a	a	DT
cord-022353-q2k2krnm	131	14	single	single	JJ
cord-022353-q2k2krnm	131	15	file	file	NN
cord-022353-q2k2krnm	131	16	in	in	IN
cord-022353-q2k2krnm	131	17	front	front	NN
cord-022353-q2k2krnm	131	18	of	of	IN
cord-022353-q2k2krnm	131	19	a	a	DT
cord-022353-q2k2krnm	131	20	two	two	CD
cord-022353-q2k2krnm	131	21	interrogating	interrogate	VBG
cord-022353-q2k2krnm	131	22	lasers	laser	NNS
cord-022353-q2k2krnm	131	23	,	,	,
cord-022353-q2k2krnm	131	24	which	which	WDT
cord-022353-q2k2krnm	131	25	allow	allow	VBP
cord-022353-q2k2krnm	131	26	for	for	IN
cord-022353-q2k2krnm	131	27	high	high	JJ
cord-022353-q2k2krnm	131	28	throughout	throughout	RB
cord-022353-q2k2krnm	131	29	.	.	.
cord-022353-q2k2krnm	132	1	One	one	CD
cord-022353-q2k2krnm	132	2	laser	laser	NN
cord-022353-q2k2krnm	132	3	is	be	VBZ
cord-022353-q2k2krnm	132	4	a	a	DT
cord-022353-q2k2krnm	132	5	red	red	JJ
cord-022353-q2k2krnm	132	6	diode	diode	NN
cord-022353-q2k2krnm	132	7	emitting	emit	VBG
cord-022353-q2k2krnm	132	8	at	at	IN
cord-022353-q2k2krnm	132	9	635	635	CD
cord-022353-q2k2krnm	132	10	nm	nm	NN
cord-022353-q2k2krnm	132	11	,	,	,
cord-022353-q2k2krnm	132	12	which	which	WDT
cord-022353-q2k2krnm	132	13	illuminates	illuminate	VBZ
cord-022353-q2k2krnm	132	14	each	each	DT
cord-022353-q2k2krnm	132	15	microsphere	microsphere	NN
cord-022353-q2k2krnm	132	16	.	.	.
cord-022353-q2k2krnm	133	1	The	the	DT
cord-022353-q2k2krnm	133	2	resulting	result	VBG
cord-022353-q2k2krnm	133	3	red	red	JJ
cord-022353-q2k2krnm	133	4	and	and	CC
cord-022353-q2k2krnm	133	5	infrared	infrared	JJ
cord-022353-q2k2krnm	133	6	fluorescence	fluorescence	NN
cord-022353-q2k2krnm	133	7	provides	provide	VBZ
cord-022353-q2k2krnm	133	8	classification	classification	NN
cord-022353-q2k2krnm	133	9	information	information	NN
cord-022353-q2k2krnm	133	10	for	for	IN
cord-022353-q2k2krnm	133	11	that	that	DT
cord-022353-q2k2krnm	133	12	particular	particular	JJ
cord-022353-q2k2krnm	133	13	microsphere	microsphere	NN
cord-022353-q2k2krnm	133	14	set	set	VBN
cord-022353-q2k2krnm	133	15	.	.	.
cord-022353-q2k2krnm	134	1	The	the	DT
cord-022353-q2k2krnm	134	2	other	other	JJ
cord-022353-q2k2krnm	134	3	laser	laser	NN
cord-022353-q2k2krnm	134	4	is	be	VBZ
cord-022353-q2k2krnm	134	5	a	a	DT
cord-022353-q2k2krnm	134	6	green	green	JJ
cord-022353-q2k2krnm	134	7	YAG	yag	NN
cord-022353-q2k2krnm	134	8	diode	diode	NN
cord-022353-q2k2krnm	134	9	emitting	emit	VBG
cord-022353-q2k2krnm	134	10	at	at	IN
cord-022353-q2k2krnm	134	11	532	532	CD
cord-022353-q2k2krnm	134	12	nm	nm	NN
cord-022353-q2k2krnm	134	13	that	that	WDT
cord-022353-q2k2krnm	134	14	excites	excite	VBZ
cord-022353-q2k2krnm	134	15	the	the	DT
cord-022353-q2k2krnm	134	16	orange	orange	JJ
cord-022353-q2k2krnm	134	17	fluorescent	fluorescent	JJ
cord-022353-q2k2krnm	134	18	reporter	reporter	NN
cord-022353-q2k2krnm	134	19	molecules	molecule	NNS
cord-022353-q2k2krnm	134	20	of	of	IN
cord-022353-q2k2krnm	134	21	the	the	DT
cord-022353-q2k2krnm	134	22	surface	surface	NN
cord-022353-q2k2krnm	134	23	of	of	IN
cord-022353-q2k2krnm	134	24	the	the	DT
cord-022353-q2k2krnm	134	25	microsphere	microsphere	NN
cord-022353-q2k2krnm	134	26	,	,	,
cord-022353-q2k2krnm	134	27	providing	provide	VBG
cord-022353-q2k2krnm	134	28	a	a	DT
cord-022353-q2k2krnm	134	29	quantitative	quantitative	JJ
cord-022353-q2k2krnm	134	30	signal	signal	NN
cord-022353-q2k2krnm	134	31	for	for	IN
cord-022353-q2k2krnm	134	32	that	that	DT
cord-022353-q2k2krnm	134	33	particular	particular	JJ
cord-022353-q2k2krnm	134	34	biologic	biologic	JJ
cord-022353-q2k2krnm	134	35	assay	assay	NN
cord-022353-q2k2krnm	134	36	.	.	.
cord-022353-q2k2krnm	135	1	The	the	DT
cord-022353-q2k2krnm	135	2	last	last	JJ
cord-022353-q2k2krnm	135	3	component	component	NN
cord-022353-q2k2krnm	135	4	is	be	VBZ
cord-022353-q2k2krnm	135	5	digital	digital	JJ
cord-022353-q2k2krnm	135	6	signal	signal	NN
cord-022353-q2k2krnm	135	7	processing	processing	NN
cord-022353-q2k2krnm	135	8	data	data	NN
cord-022353-q2k2krnm	135	9	acquisition	acquisition	NN
cord-022353-q2k2krnm	135	10	hardware	hardware	NN
cord-022353-q2k2krnm	135	11	that	that	WDT
cord-022353-q2k2krnm	135	12	provides	provide	VBZ
cord-022353-q2k2krnm	135	13	the	the	DT
cord-022353-q2k2krnm	135	14	speed	speed	NN
cord-022353-q2k2krnm	135	15	necessary	necessary	JJ
cord-022353-q2k2krnm	135	16	to	to	TO
cord-022353-q2k2krnm	135	17	read	read	VB
cord-022353-q2k2krnm	135	18	the	the	DT
cord-022353-q2k2krnm	135	19	microspheres	microsphere	NNS
cord-022353-q2k2krnm	135	20	at	at	IN
cord-022353-q2k2krnm	135	21	up	up	IN
cord-022353-q2k2krnm	135	22	to	to	TO
cord-022353-q2k2krnm	135	23	5000	5000	CD
cord-022353-q2k2krnm	135	24	per	per	IN
cord-022353-q2k2krnm	135	25	second	second	NN
cord-022353-q2k2krnm	135	26	.	.	.
cord-022353-q2k2krnm	136	1	Because	because	IN
cord-022353-q2k2krnm	136	2	multiplex	multiplex	NN
cord-022353-q2k2krnm	136	3	technology	technology	NN
cord-022353-q2k2krnm	136	4	can	can	MD
cord-022353-q2k2krnm	136	5	analyze	analyze	VB
cord-022353-q2k2krnm	136	6	a	a	DT
cord-022353-q2k2krnm	136	7	wide	wide	JJ
cord-022353-q2k2krnm	136	8	range	range	NN
cord-022353-q2k2krnm	136	9	of	of	IN
cord-022353-q2k2krnm	136	10	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	136	11	simultaneously	simultaneously	RB
cord-022353-q2k2krnm	136	12	,	,	,
cord-022353-q2k2krnm	136	13	dynamic	dynamic	JJ
cord-022353-q2k2krnm	136	14	reference	reference	NN
cord-022353-q2k2krnm	136	15	results	result	NNS
cord-022353-q2k2krnm	136	16	(	(	-LRB-
cord-022353-q2k2krnm	136	17	plasma	plasma	NN
cord-022353-q2k2krnm	136	18	profiles	profile	NNS
cord-022353-q2k2krnm	136	19	)	)	-RRB-
cord-022353-q2k2krnm	136	20	can	can	MD
cord-022353-q2k2krnm	136	21	be	be	VB
cord-022353-q2k2krnm	136	22	developed	develop	VBN
cord-022353-q2k2krnm	136	23	based	base	VBN
cord-022353-q2k2krnm	136	24	on	on	IN
cord-022353-q2k2krnm	136	25	the	the	DT
cord-022353-q2k2krnm	136	26	changing	change	VBG
cord-022353-q2k2krnm	136	27	concentrations	concentration	NNS
cord-022353-q2k2krnm	136	28	of	of	IN
cord-022353-q2k2krnm	136	29	the	the	DT
cord-022353-q2k2krnm	136	30	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	136	31	during	during	IN
cord-022353-q2k2krnm	136	32	the	the	DT
cord-022353-q2k2krnm	136	33	course	course	NN
cord-022353-q2k2krnm	136	34	of	of	IN
cord-022353-q2k2krnm	136	35	a	a	DT
cord-022353-q2k2krnm	136	36	disease	disease	NN
cord-022353-q2k2krnm	136	37	.	.	.
cord-022353-q2k2krnm	137	1	The	the	DT
cord-022353-q2k2krnm	137	2	known	known	JJ
cord-022353-q2k2krnm	137	3	and	and	CC
cord-022353-q2k2krnm	137	4	potential	potential	JJ
cord-022353-q2k2krnm	137	5	applications	application	NNS
cord-022353-q2k2krnm	137	6	of	of	IN
cord-022353-q2k2krnm	137	7	developing	develop	VBG
cord-022353-q2k2krnm	137	8	plasma	plasma	NN
cord-022353-q2k2krnm	137	9	profiles	profile	NNS
cord-022353-q2k2krnm	137	10	of	of	IN
cord-022353-q2k2krnm	137	11	diseases	disease	NNS
cord-022353-q2k2krnm	137	12	are	be	VBP
cord-022353-q2k2krnm	137	13	powerful	powerful	JJ
cord-022353-q2k2krnm	137	14	.	.	.
cord-022353-q2k2krnm	138	1	Plasma	plasma	NN
cord-022353-q2k2krnm	138	2	profiles	profile	NNS
cord-022353-q2k2krnm	138	3	can	can	MD
cord-022353-q2k2krnm	138	4	be	be	VB
cord-022353-q2k2krnm	138	5	used	use	VBN
cord-022353-q2k2krnm	138	6	to	to	TO
cord-022353-q2k2krnm	138	7	screen	screen	VB
cord-022353-q2k2krnm	138	8	and	and	CC
cord-022353-q2k2krnm	138	9	identify	identify	VB
cord-022353-q2k2krnm	138	10	diseases	disease	NNS
cord-022353-q2k2krnm	138	11	(	(	-LRB-
cord-022353-q2k2krnm	138	12	especially	especially	RB
cord-022353-q2k2krnm	138	13	during	during	IN
cord-022353-q2k2krnm	138	14	the	the	DT
cord-022353-q2k2krnm	138	15	early	early	JJ
cord-022353-q2k2krnm	138	16	development	development	NN
cord-022353-q2k2krnm	138	17	 	 	_SP
cord-022353-q2k2krnm	138	18	of	of	IN
cord-022353-q2k2krnm	138	19	a	a	DT
cord-022353-q2k2krnm	138	20	disease	disease	NN
cord-022353-q2k2krnm	138	21	)	)	-RRB-
cord-022353-q2k2krnm	138	22	and	and	CC
cord-022353-q2k2krnm	138	23	characterize	characterize	VB
cord-022353-q2k2krnm	138	24	the	the	DT
cord-022353-q2k2krnm	138	25	efficacy	efficacy	NN
cord-022353-q2k2krnm	138	26	of	of	IN
cord-022353-q2k2krnm	138	27	drugs	drug	NNS
cord-022353-q2k2krnm	138	28	targeted	target	VBN
cord-022353-q2k2krnm	138	29	against	against	IN
cord-022353-q2k2krnm	138	30	these	these	DT
cord-022353-q2k2krnm	138	31	diseases	disease	NNS
cord-022353-q2k2krnm	138	32	.	.	.
cord-022353-q2k2krnm	139	1	Multiplex	multiplex	NN
cord-022353-q2k2krnm	139	2	technology	technology	NN
cord-022353-q2k2krnm	139	3	can	can	MD
cord-022353-q2k2krnm	139	4	help	help	VB
cord-022353-q2k2krnm	139	5	elucidate	elucidate	VB
cord-022353-q2k2krnm	139	6	new	new	JJ
cord-022353-q2k2krnm	139	7	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	139	8	of	of	IN
cord-022353-q2k2krnm	139	9	disease	disease	NN
cord-022353-q2k2krnm	139	10	.	.	.
cord-022353-q2k2krnm	140	1	Furthermore	furthermore	RB
cord-022353-q2k2krnm	140	2	,	,	,
cord-022353-q2k2krnm	140	3	plasma	plasma	NN
cord-022353-q2k2krnm	140	4	profiles	profile	NNS
cord-022353-q2k2krnm	140	5	could	could	MD
cord-022353-q2k2krnm	140	6	also	also	RB
cord-022353-q2k2krnm	140	7	potentially	potentially	RB
cord-022353-q2k2krnm	140	8	be	be	VB
cord-022353-q2k2krnm	140	9	developed	develop	VBN
cord-022353-q2k2krnm	140	10	to	to	TO
cord-022353-q2k2krnm	140	11	monitor	monitor	VB
cord-022353-q2k2krnm	140	12	the	the	DT
cord-022353-q2k2krnm	140	13	blood	blood	NN
cord-022353-q2k2krnm	140	14	concentrations	concentration	NNS
cord-022353-q2k2krnm	140	15	of	of	IN
cord-022353-q2k2krnm	140	16	drugs	drug	NNS
cord-022353-q2k2krnm	140	17	as	as	RB
cord-022353-q2k2krnm	140	18	well	well	RB
cord-022353-q2k2krnm	140	19	.	.	.
cord-022353-q2k2krnm	141	1	Investigators	investigator	NNS
cord-022353-q2k2krnm	141	2	seeking	seek	VBG
cord-022353-q2k2krnm	141	3	additional	additional	JJ
cord-022353-q2k2krnm	141	4	information	information	NN
cord-022353-q2k2krnm	141	5	on	on	IN
cord-022353-q2k2krnm	141	6	availability	availability	NN
cord-022353-q2k2krnm	141	7	of	of	IN
cord-022353-q2k2krnm	141	8	reagents	reagent	NNS
cord-022353-q2k2krnm	141	9	and	and	CC
cord-022353-q2k2krnm	141	10	test	test	NN
cord-022353-q2k2krnm	141	11	kits	kit	NNS
cord-022353-q2k2krnm	141	12	should	should	MD
cord-022353-q2k2krnm	141	13	refer	refer	VB
cord-022353-q2k2krnm	141	14	to	to	IN
cord-022353-q2k2krnm	141	15	"	"	``
cord-022353-q2k2krnm	141	16	Clinical	Clinical	NNP
cord-022353-q2k2krnm	141	17	Laboratory	Laboratory	NNP
cord-022353-q2k2krnm	141	18	Reference	Reference	NNP
cord-022353-q2k2krnm	141	19	"	"	''
cord-022353-q2k2krnm	141	20	(	(	-LRB-
cord-022353-q2k2krnm	141	21	Nelson	Nelson	NNP
cord-022353-q2k2krnm	141	22	2006	2006	CD
cord-022353-q2k2krnm	141	23	)	)	-RRB-
cord-022353-q2k2krnm	141	24	and	and	CC
cord-022353-q2k2krnm	141	25	the	the	DT
cord-022353-q2k2krnm	141	26	Linscott	Linscott	NNP
cord-022353-q2k2krnm	141	27	's	's	POS
cord-022353-q2k2krnm	141	28	Directory	Directory	NNP
cord-022353-q2k2krnm	141	29	of	of	IN
cord-022353-q2k2krnm	141	30	Immunologic	Immunologic	NNP
cord-022353-q2k2krnm	141	31	and	and	CC
cord-022353-q2k2krnm	141	32	Biologic	Biologic	NNP
cord-022353-q2k2krnm	141	33	Reagents	Reagents	NNPS
cord-022353-q2k2krnm	141	34	(	(	-LRB-
cord-022353-q2k2krnm	141	35	Linscott	Linscott	NNP
cord-022353-q2k2krnm	141	36	2005	2005	CD
cord-022353-q2k2krnm	141	37	)	)	-RRB-
cord-022353-q2k2krnm	141	38	.	.	.
cord-022353-q2k2krnm	142	1	Sections	section	NNS
cord-022353-q2k2krnm	142	2	of	of	IN
cord-022353-q2k2krnm	142	3	these	these	DT
cord-022353-q2k2krnm	142	4	two	two	CD
cord-022353-q2k2krnm	142	5	references	reference	NNS
cord-022353-q2k2krnm	142	6	provide	provide	VBP
cord-022353-q2k2krnm	142	7	the	the	DT
cord-022353-q2k2krnm	142	8	names	name	NNS
cord-022353-q2k2krnm	142	9	and	and	CC
cord-022353-q2k2krnm	142	10	addresses	address	NNS
cord-022353-q2k2krnm	142	11	of	of	IN
cord-022353-q2k2krnm	142	12	sources	source	NNS
cord-022353-q2k2krnm	142	13	.	.	.
cord-022353-q2k2krnm	143	1	The	the	DT
cord-022353-q2k2krnm	143	2	catalogs	catalog	NNS
cord-022353-q2k2krnm	143	3	of	of	IN
cord-022353-q2k2krnm	143	4	individual	individual	JJ
cord-022353-q2k2krnm	143	5	companies	company	NNS
cord-022353-q2k2krnm	143	6	may	may	MD
cord-022353-q2k2krnm	143	7	be	be	VB
cord-022353-q2k2krnm	143	8	fruitful	fruitful	JJ
cord-022353-q2k2krnm	143	9	,	,	,
cord-022353-q2k2krnm	143	10	but	but	CC
cord-022353-q2k2krnm	143	11	many	many	JJ
cord-022353-q2k2krnm	143	12	reagents	reagent	NNS
cord-022353-q2k2krnm	143	13	for	for	IN
cord-022353-q2k2krnm	143	14	use	use	NN
cord-022353-q2k2krnm	143	15	in	in	IN
cord-022353-q2k2krnm	143	16	human	human	JJ
cord-022353-q2k2krnm	143	17	blood	blood	NN
cord-022353-q2k2krnm	143	18	and	and	CC
cord-022353-q2k2krnm	143	19	have	have	VBP
cord-022353-q2k2krnm	143	20	not	not	RB
cord-022353-q2k2krnm	143	21	been	be	VBN
cord-022353-q2k2krnm	143	22	validated	validate	VBN
cord-022353-q2k2krnm	143	23	for	for	IN
cord-022353-q2k2krnm	143	24	use	use	NN
cord-022353-q2k2krnm	143	25	in	in	IN
cord-022353-q2k2krnm	143	26	other	other	JJ
cord-022353-q2k2krnm	143	27	species	specie	NNS
cord-022353-q2k2krnm	143	28	(	(	-LRB-
cord-022353-q2k2krnm	143	29	including	include	VBG
cord-022353-q2k2krnm	143	30	the	the	DT
cord-022353-q2k2krnm	143	31	mouse	mouse	NN
cord-022353-q2k2krnm	143	32	)	)	-RRB-
cord-022353-q2k2krnm	143	33	.	.	.
cord-022353-q2k2krnm	144	1	Each	each	DT
cord-022353-q2k2krnm	144	2	of	of	IN
cord-022353-q2k2krnm	144	3	the	the	DT
cord-022353-q2k2krnm	144	4	various	various	JJ
cord-022353-q2k2krnm	144	5	instruments	instrument	NNS
cord-022353-q2k2krnm	144	6	mentioned	mention	VBN
cord-022353-q2k2krnm	144	7	in	in	IN
cord-022353-q2k2krnm	144	8	this	this	DT
cord-022353-q2k2krnm	144	9	section	section	NN
cord-022353-q2k2krnm	144	10	may	may	MD
cord-022353-q2k2krnm	144	11	be	be	VB
cord-022353-q2k2krnm	144	12	found	find	VBN
cord-022353-q2k2krnm	144	13	in	in	IN
cord-022353-q2k2krnm	144	14	the	the	DT
cord-022353-q2k2krnm	144	15	8th	8th	JJ
cord-022353-q2k2krnm	144	16	Annual	Annual	NNP
cord-022353-q2k2krnm	144	17	Analyzers	Analyzers	NNPS
cord-022353-q2k2krnm	144	18	Buyer	Buyer	NNP
cord-022353-q2k2krnm	144	19	's	's	POS
cord-022353-q2k2krnm	144	20	Guide	Guide	NNP
cord-022353-q2k2krnm	144	21	(	(	-LRB-
cord-022353-q2k2krnm	144	22	Advance	Advance	NNP
cord-022353-q2k2krnm	144	23	for	for	IN
cord-022353-q2k2krnm	144	24	Administrator	Administrator	NNP
cord-022353-q2k2krnm	144	25	of	of	IN
cord-022353-q2k2krnm	144	26	the	the	DT
cord-022353-q2k2krnm	144	27	Laboratory	Laboratory	NNP
cord-022353-q2k2krnm	144	28	2003	2003	CD
cord-022353-q2k2krnm	144	29	)	)	-RRB-
cord-022353-q2k2krnm	144	30	.	.	.
cord-022353-q2k2krnm	145	1	This	this	DT
cord-022353-q2k2krnm	145	2	guide	guide	NN
cord-022353-q2k2krnm	145	3	lists	list	VBZ
cord-022353-q2k2krnm	145	4	all	all	DT
cord-022353-q2k2krnm	145	5	manufacturers	manufacturer	NNS
cord-022353-q2k2krnm	145	6	and	and	CC
cord-022353-q2k2krnm	145	7	gives	give	VBZ
cord-022353-q2k2krnm	145	8	detailed	detailed	JJ
cord-022353-q2k2krnm	145	9	information	information	NN
cord-022353-q2k2krnm	145	10	on	on	IN
cord-022353-q2k2krnm	145	11	each	each	DT
cord-022353-q2k2krnm	145	12	instrument	instrument	NN
cord-022353-q2k2krnm	145	13	including	include	VBG
cord-022353-q2k2krnm	145	14	technology	technology	NN
cord-022353-q2k2krnm	145	15	platforms	platform	NNS
cord-022353-q2k2krnm	145	16	,	,	,
cord-022353-q2k2krnm	145	17	methods	method	NNS
cord-022353-q2k2krnm	145	18	used	use	VBN
cord-022353-q2k2krnm	145	19	,	,	,
cord-022353-q2k2krnm	145	20	through	through	IN
cord-022353-q2k2krnm	145	21	-	-	HYPH
cord-022353-q2k2krnm	145	22	put	put	NN
cord-022353-q2k2krnm	145	23	capability	capability	NN
cord-022353-q2k2krnm	145	24	,	,	,
cord-022353-q2k2krnm	145	25	purchase	purchase	NN
cord-022353-q2k2krnm	145	26	price	price	NN
cord-022353-q2k2krnm	145	27	,	,	,
cord-022353-q2k2krnm	145	28	maintenance	maintenance	NN
cord-022353-q2k2krnm	145	29	costs	cost	NNS
cord-022353-q2k2krnm	145	30	,	,	,
cord-022353-q2k2krnm	145	31	reagent	reagent	NN
cord-022353-q2k2krnm	145	32	package	package	NN
cord-022353-q2k2krnm	145	33	cost	cost	NN
cord-022353-q2k2krnm	145	34	,	,	,
cord-022353-q2k2krnm	145	35	as	as	RB
cord-022353-q2k2krnm	145	36	well	well	RB
cord-022353-q2k2krnm	145	37	as	as	IN
cord-022353-q2k2krnm	145	38	a	a	DT
cord-022353-q2k2krnm	145	39	variety	variety	NN
cord-022353-q2k2krnm	145	40	of	of	IN
cord-022353-q2k2krnm	145	41	options	option	NNS
cord-022353-q2k2krnm	145	42	available	available	JJ
cord-022353-q2k2krnm	145	43	.	.	.
cord-022353-q2k2krnm	146	1	Contact	contact	NN
cord-022353-q2k2krnm	146	2	information	information	NN
cord-022353-q2k2krnm	146	3	,	,	,
cord-022353-q2k2krnm	146	4	including	include	VBG
cord-022353-q2k2krnm	146	5	Web	web	NN
cord-022353-q2k2krnm	146	6	site	site	NN
cord-022353-q2k2krnm	146	7	,	,	,
cord-022353-q2k2krnm	146	8	is	be	VBZ
cord-022353-q2k2krnm	146	9	available	available	JJ
cord-022353-q2k2krnm	146	10	for	for	IN
cord-022353-q2k2krnm	146	11	each	each	DT
cord-022353-q2k2krnm	146	12	manufacturer	manufacturer	NN
cord-022353-q2k2krnm	146	13	.	.	.
cord-022353-q2k2krnm	147	1	Additional	additional	JJ
cord-022353-q2k2krnm	147	2	information	information	NN
cord-022353-q2k2krnm	147	3	regarding	regard	VBG
cord-022353-q2k2krnm	147	4	clinical	clinical	JJ
cord-022353-q2k2krnm	147	5	chemistry	chemistry	NN
cord-022353-q2k2krnm	147	6	on	on	IN
cord-022353-q2k2krnm	147	7	animal	animal	NN
cord-022353-q2k2krnm	147	8	blood	blood	NN
cord-022353-q2k2krnm	147	9	is	be	VBZ
cord-022353-q2k2krnm	147	10	available	available	JJ
cord-022353-q2k2krnm	147	11	on	on	IN
cord-022353-q2k2krnm	147	12	the	the	DT
cord-022353-q2k2krnm	147	13	Web	web	NN
cord-022353-q2k2krnm	147	14	site	site	NN
cord-022353-q2k2krnm	147	15	of	of	IN
cord-022353-q2k2krnm	147	16	the	the	DT
cord-022353-q2k2krnm	147	17	Division	Division	NNP
cord-022353-q2k2krnm	147	18	of	of	IN
cord-022353-q2k2krnm	147	19	Animal	Animal	NNP
cord-022353-q2k2krnm	147	20	Clinical	Clinical	NNP
cord-022353-q2k2krnm	147	21	Chemistry	Chemistry	NNP
cord-022353-q2k2krnm	147	22	at	at	IN
cord-022353-q2k2krnm	147	23	the	the	DT
cord-022353-q2k2krnm	147	24	American	American	NNP
cord-022353-q2k2krnm	147	25	Association	Association	NNP
cord-022353-q2k2krnm	147	26	of	of	IN
cord-022353-q2k2krnm	147	27	Clinical	Clinical	NNP
cord-022353-q2k2krnm	147	28	Chemistry	Chemistry	NNP
cord-022353-q2k2krnm	147	29	(	(	-LRB-
cord-022353-q2k2krnm	147	30	www.aacc.org/divisions/animal	www.aacc.org/divisions/animal	NNP
cord-022353-q2k2krnm	147	31	)	)	-RRB-
cord-022353-q2k2krnm	147	32	.	.	.
cord-022353-q2k2krnm	148	1	With	with	IN
cord-022353-q2k2krnm	148	2	a	a	DT
cord-022353-q2k2krnm	148	3	mean	mean	JJ
cord-022353-q2k2krnm	148	4	body	body	NN
cord-022353-q2k2krnm	148	5	size	size	NN
cord-022353-q2k2krnm	148	6	of	of	IN
cord-022353-q2k2krnm	148	7	35	35	CD
cord-022353-q2k2krnm	148	8	g	g	NN
cord-022353-q2k2krnm	148	9	,	,	,
cord-022353-q2k2krnm	148	10	adult	adult	NN
cord-022353-q2k2krnm	148	11	mice	mouse	NNS
cord-022353-q2k2krnm	148	12	have	have	VBP
cord-022353-q2k2krnm	148	13	approximately	approximately	RB
cord-022353-q2k2krnm	148	14	2.4	2.4	CD
cord-022353-q2k2krnm	148	15	ml	ml	NNS
cord-022353-q2k2krnm	148	16	of	of	IN
cord-022353-q2k2krnm	148	17	blood	blood	NN
cord-022353-q2k2krnm	148	18	volume	volume	NN
cord-022353-q2k2krnm	148	19	,	,	,
cord-022353-q2k2krnm	148	20	allowing	allow	VBG
cord-022353-q2k2krnm	148	21	75	75	CD
cord-022353-q2k2krnm	148	22	~tl	~tl	VBN
cord-022353-q2k2krnm	148	23	to	to	TO
cord-022353-q2k2krnm	148	24	be	be	VB
cord-022353-q2k2krnm	148	25	removed	remove	VBN
cord-022353-q2k2krnm	148	26	weekly	weekly	RB
cord-022353-q2k2krnm	148	27	without	without	IN
cord-022353-q2k2krnm	148	28	consequence	consequence	NN
cord-022353-q2k2krnm	148	29	to	to	IN
cord-022353-q2k2krnm	148	30	health	health	NN
cord-022353-q2k2krnm	148	31	and	and	CC
cord-022353-q2k2krnm	148	32	welfare	welfare	NN
cord-022353-q2k2krnm	148	33	(	(	-LRB-
cord-022353-q2k2krnm	148	34	Loeb	Loeb	NNP
cord-022353-q2k2krnm	148	35	1997	1997	CD
cord-022353-q2k2krnm	148	36	;	;	:
cord-022353-q2k2krnm	148	37	Loeb	Loeb	NNP
cord-022353-q2k2krnm	148	38	and	and	CC
cord-022353-q2k2krnm	148	39	Quimby	Quimby	NNP
cord-022353-q2k2krnm	148	40	1999	1999	CD
cord-022353-q2k2krnm	148	41	)	)	-RRB-
cord-022353-q2k2krnm	148	42	.	.	.
cord-022353-q2k2krnm	149	1	Four	four	CD
cord-022353-q2k2krnm	149	2	blood	blood	NN
cord-022353-q2k2krnm	149	3	collection	collection	NN
cord-022353-q2k2krnm	149	4	sites	site	NNS
cord-022353-q2k2krnm	149	5	for	for	IN
cord-022353-q2k2krnm	149	6	acquiring	acquire	VBG
cord-022353-q2k2krnm	149	7	75	75	CD
cord-022353-q2k2krnm	149	8	~tl	~tl	NN
cord-022353-q2k2krnm	149	9	of	of	IN
cord-022353-q2k2krnm	149	10	blood	blood	NN
cord-022353-q2k2krnm	149	11	repetitively	repetitively	RB
cord-022353-q2k2krnm	149	12	from	from	IN
cord-022353-q2k2krnm	149	13	adult	adult	NN
cord-022353-q2k2krnm	149	14	mice	mouse	NNS
cord-022353-q2k2krnm	149	15	include	include	VBP
cord-022353-q2k2krnm	149	16	the	the	DT
cord-022353-q2k2krnm	149	17	orbital	orbital	JJ
cord-022353-q2k2krnm	149	18	plexus	plexus	NN
cord-022353-q2k2krnm	149	19	,	,	,
cord-022353-q2k2krnm	149	20	the	the	DT
cord-022353-q2k2krnm	149	21	tail	tail	NN
cord-022353-q2k2krnm	149	22	vein	vein	NN
cord-022353-q2k2krnm	149	23	,	,	,
cord-022353-q2k2krnm	149	24	the	the	DT
cord-022353-q2k2krnm	149	25	jugular	jugular	NN
cord-022353-q2k2krnm	149	26	vein	vein	NN
cord-022353-q2k2krnm	149	27	,	,	,
cord-022353-q2k2krnm	149	28	and	and	CC
cord-022353-q2k2krnm	149	29	cardiac	cardiac	JJ
cord-022353-q2k2krnm	149	30	puncture	puncture	NN
cord-022353-q2k2krnm	149	31	(	(	-LRB-
cord-022353-q2k2krnm	149	32	Quimby	Quimby	NNP
cord-022353-q2k2krnm	149	33	1999b	1999b	CD
cord-022353-q2k2krnm	149	34	)	)	-RRB-
cord-022353-q2k2krnm	149	35	.	.	.
cord-022353-q2k2krnm	150	1	General	general	JJ
cord-022353-q2k2krnm	150	2	anesthesia	anesthesia	NNP
cord-022353-q2k2krnm	150	3	is	be	VBZ
cord-022353-q2k2krnm	150	4	recommended	recommend	VBN
cord-022353-q2k2krnm	150	5	for	for	IN
cord-022353-q2k2krnm	150	6	orbital	orbital	JJ
cord-022353-q2k2krnm	150	7	plexus	plexus	NN
cord-022353-q2k2krnm	150	8	and	and	CC
cord-022353-q2k2krnm	150	9	cardiac	cardiac	JJ
cord-022353-q2k2krnm	150	10	puncture	puncture	NN
cord-022353-q2k2krnm	150	11	,	,	,
cord-022353-q2k2krnm	150	12	although	although	IN
cord-022353-q2k2krnm	150	13	Terril-	Terril-	NNP
cord-022353-q2k2krnm	150	14	Robb	Robb	NNP
cord-022353-q2k2krnm	150	15	et	et	FW
cord-022353-q2k2krnm	150	16	al	al	NNP
cord-022353-q2k2krnm	150	17	.	.	.
cord-022353-q2k2krnm	151	1	(	(	-LRB-
cord-022353-q2k2krnm	151	2	1996	1996	CD
cord-022353-q2k2krnm	151	3	)	)	-RRB-
cord-022353-q2k2krnm	151	4	claim	claim	VBP
cord-022353-q2k2krnm	151	5	that	that	IN
cord-022353-q2k2krnm	151	6	topical	topical	JJ
cord-022353-q2k2krnm	151	7	application	application	NN
cord-022353-q2k2krnm	151	8	of	of	IN
cord-022353-q2k2krnm	151	9	proparacaine	proparacaine	NN
cord-022353-q2k2krnm	151	10	hydrochloride	hydrochloride	NNP
cord-022353-q2k2krnm	151	11	is	be	VBZ
cord-022353-q2k2krnm	151	12	an	an	DT
cord-022353-q2k2krnm	151	13	acceptable	acceptable	JJ
cord-022353-q2k2krnm	151	14	procedure	procedure	NN
cord-022353-q2k2krnm	151	15	for	for	IN
cord-022353-q2k2krnm	151	16	collecting	collect	VBG
cord-022353-q2k2krnm	151	17	orbital	orbital	JJ
cord-022353-q2k2krnm	151	18	plexus	plexus	NN
cord-022353-q2k2krnm	151	19	blood	blood	NN
cord-022353-q2k2krnm	151	20	.	.	.
cord-022353-q2k2krnm	152	1	The	the	DT
cord-022353-q2k2krnm	152	2	jugular	jugular	NN
cord-022353-q2k2krnm	152	3	vein	vein	NN
cord-022353-q2k2krnm	152	4	is	be	VBZ
cord-022353-q2k2krnm	152	5	punctured	puncture	VBN
cord-022353-q2k2krnm	152	6	using	use	VBG
cord-022353-q2k2krnm	152	7	a	a	DT
cord-022353-q2k2krnm	152	8	lancet	lancet	NN
cord-022353-q2k2krnm	152	9	directed	direct	VBN
cord-022353-q2k2krnm	152	10	at	at	IN
cord-022353-q2k2krnm	152	11	the	the	DT
cord-022353-q2k2krnm	152	12	rear	rear	NN
cord-022353-q2k2krnm	152	13	of	of	IN
cord-022353-q2k2krnm	152	14	the	the	DT
cord-022353-q2k2krnm	152	15	jaw	jaw	NN
cord-022353-q2k2krnm	152	16	,	,	,
cord-022353-q2k2krnm	152	17	exposing	expose	VBG
cord-022353-q2k2krnm	152	18	the	the	DT
cord-022353-q2k2krnm	152	19	jugular	jugular	NN
cord-022353-q2k2krnm	152	20	vein	vein	NN
cord-022353-q2k2krnm	152	21	and	and	CC
cord-022353-q2k2krnm	152	22	its	-PRON-	PRP$
cord-022353-q2k2krnm	152	23	tributaries	tributary	NNS
cord-022353-q2k2krnm	152	24	and	and	CC
cord-022353-q2k2krnm	152	25	the	the	DT
cord-022353-q2k2krnm	152	26	submandibular	submandibular	JJ
cord-022353-q2k2krnm	152	27	and	and	CC
cord-022353-q2k2krnm	152	28	facial	facial	JJ
cord-022353-q2k2krnm	152	29	veins	vein	NNS
cord-022353-q2k2krnm	152	30	(	(	-LRB-
cord-022353-q2k2krnm	152	31	Golde	Golde	NNP
cord-022353-q2k2krnm	152	32	et	et	NNP
cord-022353-q2k2krnm	152	33	al	al	NNP
cord-022353-q2k2krnm	152	34	.	.	NNP
cord-022353-q2k2krnm	152	35	2005	2005	CD
cord-022353-q2k2krnm	152	36	)	)	-RRB-
cord-022353-q2k2krnm	152	37	.	.	.
cord-022353-q2k2krnm	153	1	Collection	collection	NN
cord-022353-q2k2krnm	153	2	of	of	IN
cord-022353-q2k2krnm	153	3	blood	blood	NN
cord-022353-q2k2krnm	153	4	from	from	IN
cord-022353-q2k2krnm	153	5	any	any	DT
cord-022353-q2k2krnm	153	6	of	of	IN
cord-022353-q2k2krnm	153	7	these	these	DT
cord-022353-q2k2krnm	153	8	veins	vein	NNS
cord-022353-q2k2krnm	153	9	at	at	IN
cord-022353-q2k2krnm	153	10	this	this	DT
cord-022353-q2k2krnm	153	11	site	site	NN
cord-022353-q2k2krnm	153	12	works	work	VBZ
cord-022353-q2k2krnm	153	13	well	well	RB
cord-022353-q2k2krnm	153	14	,	,	,
cord-022353-q2k2krnm	153	15	and	and	CC
cord-022353-q2k2krnm	153	16	the	the	DT
cord-022353-q2k2krnm	153	17	animal	animal	NN
cord-022353-q2k2krnm	153	18	does	do	VBZ
cord-022353-q2k2krnm	153	19	not	not	RB
cord-022353-q2k2krnm	153	20	require	require	VB
cord-022353-q2k2krnm	153	21	anesthesia	anesthesia	NN
cord-022353-q2k2krnm	153	22	or	or	CC
cord-022353-q2k2krnm	153	23	a	a	DT
cord-022353-q2k2krnm	153	24	restraint	restraint	NN
cord-022353-q2k2krnm	153	25	device	device	NN
cord-022353-q2k2krnm	153	26	.	.	.
cord-022353-q2k2krnm	154	1	The	the	DT
cord-022353-q2k2krnm	154	2	blood	blood	NN
cord-022353-q2k2krnm	154	3	should	should	MD
cord-022353-q2k2krnm	154	4	be	be	VB
cord-022353-q2k2krnm	154	5	collected	collect	VBN
cord-022353-q2k2krnm	154	6	with	with	IN
cord-022353-q2k2krnm	154	7	a	a	DT
cord-022353-q2k2krnm	154	8	small	small	JJ
cord-022353-q2k2krnm	154	9	centrifuge	centrifuge	NN
cord-022353-q2k2krnm	154	10	tube	tube	NN
cord-022353-q2k2krnm	154	11	or	or	CC
cord-022353-q2k2krnm	154	12	capillary	capillary	JJ
cord-022353-q2k2krnm	154	13	tube	tube	NN
cord-022353-q2k2krnm	154	14	.	.	.
cord-022353-q2k2krnm	155	1	Nerenberg	Nerenberg	NNP
cord-022353-q2k2krnm	155	2	and	and	CC
cord-022353-q2k2krnm	155	3	Zedler	Zedler	NNP
cord-022353-q2k2krnm	155	4	(	(	-LRB-
cord-022353-q2k2krnm	155	5	1975	1975	CD
cord-022353-q2k2krnm	155	6	)	)	-RRB-
cord-022353-q2k2krnm	155	7	describe	describe	VB
cord-022353-q2k2krnm	155	8	a	a	DT
cord-022353-q2k2krnm	155	9	vacuum	vacuum	NN
cord-022353-q2k2krnm	155	10	apparatus	apparatus	NN
cord-022353-q2k2krnm	155	11	used	use	VBN
cord-022353-q2k2krnm	155	12	to	to	TO
cord-022353-q2k2krnm	155	13	collect	collect	VB
cord-022353-q2k2krnm	155	14	larger	large	JJR
cord-022353-q2k2krnm	155	15	volumes	volume	NNS
cord-022353-q2k2krnm	155	16	of	of	IN
cord-022353-q2k2krnm	155	17	blood	blood	NN
cord-022353-q2k2krnm	155	18	from	from	IN
cord-022353-q2k2krnm	155	19	the	the	DT
cord-022353-q2k2krnm	155	20	tail	tail	NN
cord-022353-q2k2krnm	155	21	vein	vein	NN
cord-022353-q2k2krnm	155	22	.	.	.
cord-022353-q2k2krnm	156	1	Lewis	Lewis	NNP
cord-022353-q2k2krnm	156	2	et	et	NNP
cord-022353-q2k2krnm	156	3	al	al	NNP
cord-022353-q2k2krnm	156	4	.	.	.
cord-022353-q2k2krnm	157	1	(	(	-LRB-
cord-022353-q2k2krnm	157	2	1976	1976	CD
cord-022353-q2k2krnm	157	3	)	)	-RRB-
cord-022353-q2k2krnm	157	4	found	find	VBD
cord-022353-q2k2krnm	157	5	that	that	DT
cord-022353-q2k2krnm	157	6	heparinization	heparinization	NN
cord-022353-q2k2krnm	157	7	of	of	IN
cord-022353-q2k2krnm	157	8	mice	mouse	NNS
cord-022353-q2k2krnm	157	9	before	before	IN
cord-022353-q2k2krnm	157	10	tail	tail	NN
cord-022353-q2k2krnm	157	11	bleeding	bleeding	NN
cord-022353-q2k2krnm	157	12	increases	increase	VBZ
cord-022353-q2k2krnm	157	13	the	the	DT
cord-022353-q2k2krnm	157	14	yield	yield	NN
cord-022353-q2k2krnm	157	15	.	.	.
cord-022353-q2k2krnm	158	1	Prewarming	prewarme	VBG
cord-022353-q2k2krnm	158	2	the	the	DT
cord-022353-q2k2krnm	158	3	mouse	mouse	NN
cord-022353-q2k2krnm	158	4	under	under	IN
cord-022353-q2k2krnm	158	5	a	a	DT
cord-022353-q2k2krnm	158	6	lamp	lamp	NN
cord-022353-q2k2krnm	158	7	or	or	CC
cord-022353-q2k2krnm	158	8	through	through	IN
cord-022353-q2k2krnm	158	9	immersion	immersion	NN
cord-022353-q2k2krnm	158	10	in	in	IN
cord-022353-q2k2krnm	158	11	warm	warm	JJ
cord-022353-q2k2krnm	158	12	water	water	NN
cord-022353-q2k2krnm	158	13	facilitates	facilitate	VBZ
cord-022353-q2k2krnm	158	14	tail	tail	NN
cord-022353-q2k2krnm	158	15	bleeding	bleeding	NN
cord-022353-q2k2krnm	158	16	.	.	.
cord-022353-q2k2krnm	159	1	The	the	DT
cord-022353-q2k2krnm	159	2	use	use	NN
cord-022353-q2k2krnm	159	3	of	of	IN
cord-022353-q2k2krnm	159	4	heparinized	heparinized	NNP
cord-022353-q2k2krnm	159	5	microhematocrit	microhematocrit	NNP
cord-022353-q2k2krnm	159	6	tubes	tube	NNS
cord-022353-q2k2krnm	159	7	,	,	,
cord-022353-q2k2krnm	159	8	during	during	IN
cord-022353-q2k2krnm	159	9	tail	tail	NN
cord-022353-q2k2krnm	159	10	or	or	CC
cord-022353-q2k2krnm	159	11	orbital	orbital	JJ
cord-022353-q2k2krnm	159	12	plexus	plexus	NN
cord-022353-q2k2krnm	159	13	bleeding	bleeding	NN
cord-022353-q2k2krnm	159	14	can	can	MD
cord-022353-q2k2krnm	159	15	maximize	maximize	VB
cord-022353-q2k2krnm	159	16	the	the	DT
cord-022353-q2k2krnm	159	17	plasma	plasma	NN
cord-022353-q2k2krnm	159	18	volume	volume	NN
cord-022353-q2k2krnm	159	19	with	with	IN
cord-022353-q2k2krnm	159	20	minimal	minimal	JJ
cord-022353-q2k2krnm	159	21	hemolysis	hemolysis	NN
cord-022353-q2k2krnm	159	22	(	(	-LRB-
cord-022353-q2k2krnm	159	23	Quimby	Quimby	NNP
cord-022353-q2k2krnm	159	24	1999b	1999b	CD
cord-022353-q2k2krnm	159	25	)	)	-RRB-
cord-022353-q2k2krnm	159	26	.	.	.
cord-022353-q2k2krnm	160	1	Hem	Hem	NNP
cord-022353-q2k2krnm	160	2	and	and	CC
cord-022353-q2k2krnm	160	3	Smith	Smith	NNP
cord-022353-q2k2krnm	160	4	(	(	-LRB-
cord-022353-q2k2krnm	160	5	1998	1998	CD
cord-022353-q2k2krnm	160	6	)	)	-RRB-
cord-022353-q2k2krnm	160	7	recommend	recommend	VB
cord-022353-q2k2krnm	160	8	a	a	DT
cord-022353-q2k2krnm	160	9	saphenous	saphenous	JJ
cord-022353-q2k2krnm	160	10	vein	vein	NN
cord-022353-q2k2krnm	160	11	prick	prick	NN
cord-022353-q2k2krnm	160	12	method	method	NN
cord-022353-q2k2krnm	160	13	over	over	IN
cord-022353-q2k2krnm	160	14	the	the	DT
cord-022353-q2k2krnm	160	15	orbital	orbital	JJ
cord-022353-q2k2krnm	160	16	plexus	plexus	NN
cord-022353-q2k2krnm	160	17	method	method	NN
cord-022353-q2k2krnm	160	18	for	for	IN
cord-022353-q2k2krnm	160	19	collecting	collect	VBG
cord-022353-q2k2krnm	160	20	repeated	repeat	VBN
cord-022353-q2k2krnm	160	21	small	small	JJ
cord-022353-q2k2krnm	160	22	volumes	volume	NNS
cord-022353-q2k2krnm	160	23	from	from	IN
cord-022353-q2k2krnm	160	24	conscious	conscious	JJ
cord-022353-q2k2krnm	160	25	mice	mouse	NNS
cord-022353-q2k2krnm	160	26	.	.	.
cord-022353-q2k2krnm	161	1	MacLeod	MacLeod	NNP
cord-022353-q2k2krnm	161	2	and	and	CC
cord-022353-q2k2krnm	161	3	Shapiro	Shapiro	NNP
cord-022353-q2k2krnm	161	4	(	(	-LRB-
cord-022353-q2k2krnm	161	5	1988	1988	CD
cord-022353-q2k2krnm	161	6	)	)	-RRB-
cord-022353-q2k2krnm	161	7	used	use	VBD
cord-022353-q2k2krnm	161	8	indwelling	indwell	VBG
cord-022353-q2k2krnm	161	9	fight	fight	VB
cord-022353-q2k2krnm	161	10	atrial	atrial	JJ
cord-022353-q2k2krnm	161	11	catheters	catheter	NNS
cord-022353-q2k2krnm	161	12	for	for	IN
cord-022353-q2k2krnm	161	13	repetitive	repetitive	JJ
cord-022353-q2k2krnm	161	14	bleeding	bleeding	NN
cord-022353-q2k2krnm	161	15	of	of	IN
cord-022353-q2k2krnm	161	16	conscious	conscious	JJ
cord-022353-q2k2krnm	161	17	,	,	,
cord-022353-q2k2krnm	161	18	unstressed	unstressed	JJ
cord-022353-q2k2krnm	161	19	mice	mouse	NNS
cord-022353-q2k2krnm	161	20	.	.	.
cord-022353-q2k2krnm	162	1	Disadvantages	disadvantage	NNS
cord-022353-q2k2krnm	162	2	of	of	IN
cord-022353-q2k2krnm	162	3	specific	specific	JJ
cord-022353-q2k2krnm	162	4	procedures	procedure	NNS
cord-022353-q2k2krnm	162	5	have	have	VBP
cord-022353-q2k2krnm	162	6	been	be	VBN
cord-022353-q2k2krnm	162	7	described	describe	VBN
cord-022353-q2k2krnm	162	8	.	.	.
cord-022353-q2k2krnm	163	1	Sakaki	Sakaki	NNP
cord-022353-q2k2krnm	163	2	et	et	NNP
cord-022353-q2k2krnm	163	3	al	al	NNP
cord-022353-q2k2krnm	163	4	.	.	.
cord-022353-q2k2krnm	164	1	(	(	-LRB-
cord-022353-q2k2krnm	164	2	1961	1961	CD
cord-022353-q2k2krnm	164	3	)	)	-RRB-
cord-022353-q2k2krnm	164	4	reported	report	VBD
cord-022353-q2k2krnm	164	5	sympathetic	sympathetic	JJ
cord-022353-q2k2krnm	164	6	nervous	nervous	JJ
cord-022353-q2k2krnm	164	7	system	system	NN
cord-022353-q2k2krnm	164	8	stimulation	stimulation	NN
cord-022353-q2k2krnm	164	9	associated	associate	VBN
cord-022353-q2k2krnm	164	10	with	with	IN
cord-022353-q2k2krnm	164	11	tail	tail	NN
cord-022353-q2k2krnm	164	12	bleeding	bleeding	NN
cord-022353-q2k2krnm	164	13	and	and	CC
cord-022353-q2k2krnm	164	14	the	the	DT
cord-022353-q2k2krnm	164	15	mixing	mixing	NN
cord-022353-q2k2krnm	164	16	of	of	IN
cord-022353-q2k2krnm	164	17	venous	venous	JJ
cord-022353-q2k2krnm	164	18	and	and	CC
cord-022353-q2k2krnm	164	19	arterial	arterial	JJ
cord-022353-q2k2krnm	164	20	blood	blood	NN
cord-022353-q2k2krnm	164	21	with	with	IN
cord-022353-q2k2krnm	164	22	the	the	DT
cord-022353-q2k2krnm	164	23	orbital	orbital	JJ
cord-022353-q2k2krnm	164	24	plexus	plexus	NN
cord-022353-q2k2krnm	164	25	method	method	NN
cord-022353-q2k2krnm	164	26	.	.	.
cord-022353-q2k2krnm	165	1	Patrick	Patrick	NNP
cord-022353-q2k2krnm	165	2	et	et	NNP
cord-022353-q2k2krnm	165	3	al	al	NNP
cord-022353-q2k2krnm	165	4	.	.	.
cord-022353-q2k2krnm	166	1	(	(	-LRB-
cord-022353-q2k2krnm	166	2	1983	1983	CD
cord-022353-q2k2krnm	166	3	)	)	-RRB-
cord-022353-q2k2krnm	166	4	found	find	VBD
cord-022353-q2k2krnm	166	5	that	that	IN
cord-022353-q2k2krnm	166	6	,	,	,
cord-022353-q2k2krnm	166	7	compared	compare	VBN
cord-022353-q2k2krnm	166	8	to	to	IN
cord-022353-q2k2krnm	166	9	jugular	jugular	NNP
cord-022353-q2k2krnm	166	10	vein	vein	NN
cord-022353-q2k2krnm	166	11	collection	collection	NN
cord-022353-q2k2krnm	166	12	,	,	,
cord-022353-q2k2krnm	166	13	cardiac	cardiac	JJ
cord-022353-q2k2krnm	166	14	puncture	puncture	NN
cord-022353-q2k2krnm	166	15	was	be	VBD
cord-022353-q2k2krnm	166	16	associated	associate	VBN
cord-022353-q2k2krnm	166	17	with	with	IN
cord-022353-q2k2krnm	166	18	higher	high	JJR
cord-022353-q2k2krnm	166	19	plasma	plasma	NN
cord-022353-q2k2krnm	166	20	glucose	glucose	NN
cord-022353-q2k2krnm	166	21	concentrations	concentration	NNS
cord-022353-q2k2krnm	166	22	and	and	CC
cord-022353-q2k2krnm	166	23	lower	low	JJR
cord-022353-q2k2krnm	166	24	creatine	creatine	NN
cord-022353-q2k2krnm	166	25	kinase	kinase	NN
cord-022353-q2k2krnm	166	26	(	(	-LRB-
cord-022353-q2k2krnm	166	27	CK	CK	NNP
cord-022353-q2k2krnm	166	28	)	)	-RRB-
cord-022353-q2k2krnm	166	29	activity	activity	NN
cord-022353-q2k2krnm	166	30	.	.	.
cord-022353-q2k2krnm	167	1	Plasma	plasma	NN
cord-022353-q2k2krnm	167	2	glucose	glucose	NN
cord-022353-q2k2krnm	167	3	concentrations	concentration	NNS
cord-022353-q2k2krnm	167	4	are	be	VBP
cord-022353-q2k2krnm	167	5	higher	high	JJR
cord-022353-q2k2krnm	167	6	in	in	IN
cord-022353-q2k2krnm	167	7	blood	blood	NN
cord-022353-q2k2krnm	167	8	collected	collect	VBN
cord-022353-q2k2krnm	167	9	from	from	IN
cord-022353-q2k2krnm	167	10	the	the	DT
cord-022353-q2k2krnm	167	11	orbital	orbital	JJ
cord-022353-q2k2krnm	167	12	sinus	sinus	NN
cord-022353-q2k2krnm	167	13	compared	compare	VBN
cord-022353-q2k2krnm	167	14	to	to	IN
cord-022353-q2k2krnm	167	15	the	the	DT
cord-022353-q2k2krnm	167	16	tail	tail	NN
cord-022353-q2k2krnm	167	17	vein	vein	NN
cord-022353-q2k2krnm	167	18	.	.	.
cord-022353-q2k2krnm	168	1	Differences	difference	NNS
cord-022353-q2k2krnm	168	2	associated	associate	VBN
cord-022353-q2k2krnm	168	3	with	with	IN
cord-022353-q2k2krnm	168	4	the	the	DT
cord-022353-q2k2krnm	168	5	method	method	NN
cord-022353-q2k2krnm	168	6	of	of	IN
cord-022353-q2k2krnm	168	7	anesthesia	anesthesia	NN
cord-022353-q2k2krnm	168	8	are	be	VBP
cord-022353-q2k2krnm	168	9	also	also	RB
cord-022353-q2k2krnm	168	10	important	important	JJ
cord-022353-q2k2krnm	168	11	.	.	.
cord-022353-q2k2krnm	169	1	Halothane	Halothane	NNP
cord-022353-q2k2krnm	169	2	,	,	,
cord-022353-q2k2krnm	169	3	methoxyflurane	methoxyflurane	NNP
cord-022353-q2k2krnm	169	4	,	,	,
cord-022353-q2k2krnm	169	5	isoflurane	isoflurane	NNP
cord-022353-q2k2krnm	169	6	,	,	,
cord-022353-q2k2krnm	169	7	and	and	CC
cord-022353-q2k2krnm	169	8	pentobarbital	pentobarbital	NN
cord-022353-q2k2krnm	169	9	sodium	sodium	NN
cord-022353-q2k2krnm	169	10	have	have	VBP
cord-022353-q2k2krnm	169	11	been	be	VBN
cord-022353-q2k2krnm	169	12	widely	widely	RB
cord-022353-q2k2krnm	169	13	used	use	VBN
cord-022353-q2k2krnm	169	14	and	and	CC
cord-022353-q2k2krnm	169	15	are	be	VBP
cord-022353-q2k2krnm	169	16	considered	consider	VBN
cord-022353-q2k2krnm	169	17	safe	safe	JJ
cord-022353-q2k2krnm	169	18	.	.	.
cord-022353-q2k2krnm	170	1	However	however	RB
cord-022353-q2k2krnm	170	2	,	,	,
cord-022353-q2k2krnm	170	3	caution	caution	NN
cord-022353-q2k2krnm	170	4	should	should	MD
cord-022353-q2k2krnm	170	5	be	be	VB
cord-022353-q2k2krnm	170	6	exercised	exercise	VBN
cord-022353-q2k2krnm	170	7	in	in	IN
cord-022353-q2k2krnm	170	8	the	the	DT
cord-022353-q2k2krnm	170	9	interpretation	interpretation	NN
cord-022353-q2k2krnm	170	10	of	of	IN
cord-022353-q2k2krnm	170	11	certain	certain	JJ
cord-022353-q2k2krnm	170	12	chemistry	chemistry	NN
cord-022353-q2k2krnm	170	13	values	value	NNS
cord-022353-q2k2krnm	170	14	.	.	.
cord-022353-q2k2krnm	171	1	Higher	high	JJR
cord-022353-q2k2krnm	171	2	plasma	plasma	NN
cord-022353-q2k2krnm	171	3	glucose	glucose	NN
cord-022353-q2k2krnm	171	4	levels	level	NNS
cord-022353-q2k2krnm	171	5	are	be	VBP
cord-022353-q2k2krnm	171	6	reported	report	VBN
cord-022353-q2k2krnm	171	7	with	with	IN
cord-022353-q2k2krnm	171	8	tail	tail	NN
cord-022353-q2k2krnm	171	9	vein	vein	NN
cord-022353-q2k2krnm	171	10	sampling	sampling	NN
cord-022353-q2k2krnm	171	11	in	in	IN
cord-022353-q2k2krnm	171	12	mice	mouse	NNS
cord-022353-q2k2krnm	171	13	anesthetized	anesthetize	VBN
cord-022353-q2k2krnm	171	14	with	with	IN
cord-022353-q2k2krnm	171	15	pentobarbital	pentobarbital	NN
cord-022353-q2k2krnm	171	16	or	or	CC
cord-022353-q2k2krnm	171	17	methoxyflurane	methoxyflurane	NN
cord-022353-q2k2krnm	171	18	compared	compare	VBN
cord-022353-q2k2krnm	171	19	with	with	IN
cord-022353-q2k2krnm	171	20	conscious	conscious	JJ
cord-022353-q2k2krnm	171	21	mice	mouse	NNS
cord-022353-q2k2krnm	171	22	(	(	-LRB-
cord-022353-q2k2krnm	171	23	Chuang	Chuang	NNP
cord-022353-q2k2krnm	171	24	and	and	CC
cord-022353-q2k2krnm	171	25	Luo	Luo	NNP
cord-022353-q2k2krnm	171	26	1997	1997	CD
cord-022353-q2k2krnm	171	27	)	)	-RRB-
cord-022353-q2k2krnm	171	28	.	.	.
cord-022353-q2k2krnm	172	1	Plasma	plasma	NN
cord-022353-q2k2krnm	172	2	glucose	glucose	NN
cord-022353-q2k2krnm	172	3	levels	level	NNS
cord-022353-q2k2krnm	172	4	are	be	VBP
cord-022353-q2k2krnm	172	5	higher	high	JJR
cord-022353-q2k2krnm	172	6	after	after	IN
cord-022353-q2k2krnm	172	7	collection	collection	NN
cord-022353-q2k2krnm	172	8	from	from	IN
cord-022353-q2k2krnm	172	9	the	the	DT
cord-022353-q2k2krnm	172	10	orbital	orbital	JJ
cord-022353-q2k2krnm	172	11	plexus	plexus	NN
cord-022353-q2k2krnm	172	12	if	if	IN
cord-022353-q2k2krnm	172	13	pentobarbital	pentobarbital	JJ
cord-022353-q2k2krnm	172	14	or	or	CC
cord-022353-q2k2krnm	172	15	proparacaine	proparacaine	NN
cord-022353-q2k2krnm	172	16	hydrochloride	hydrochloride	NN
cord-022353-q2k2krnm	172	17	is	be	VBZ
cord-022353-q2k2krnm	172	18	administered	administer	VBN
cord-022353-q2k2krnm	172	19	.	.	.
cord-022353-q2k2krnm	173	1	Methoxyflurane	Methoxyflurane	NNP
cord-022353-q2k2krnm	173	2	has	have	VBZ
cord-022353-q2k2krnm	173	3	no	no	DT
cord-022353-q2k2krnm	173	4	glucose	glucose	NN
cord-022353-q2k2krnm	173	5	elevating	elevate	VBG
cord-022353-q2k2krnm	173	6	effect	effect	NN
cord-022353-q2k2krnm	173	7	on	on	IN
cord-022353-q2k2krnm	173	8	samples	sample	NNS
cord-022353-q2k2krnm	173	9	collected	collect	VBN
cord-022353-q2k2krnm	173	10	from	from	IN
cord-022353-q2k2krnm	173	11	the	the	DT
cord-022353-q2k2krnm	173	12	orbital	orbital	JJ
cord-022353-q2k2krnm	173	13	plexus	plexus	NN
cord-022353-q2k2krnm	173	14	.	.	.
cord-022353-q2k2krnm	174	1	Cunliffe	Cunliffe	NNP
cord-022353-q2k2krnm	174	2	-	-	HYPH
cord-022353-q2k2krnm	174	3	Beamer	Beamer	NNP
cord-022353-q2k2krnm	174	4	(	(	-LRB-
cord-022353-q2k2krnm	174	5	1983	1983	CD
cord-022353-q2k2krnm	174	6	)	)	-RRB-
cord-022353-q2k2krnm	174	7	claims	claim	VBZ
cord-022353-q2k2krnm	174	8	that	that	IN
cord-022353-q2k2krnm	174	9	carbon	carbon	NN
cord-022353-q2k2krnm	174	10	dioxide	dioxide	NN
cord-022353-q2k2krnm	174	11	narcosis	narcosis	NN
cord-022353-q2k2krnm	174	12	provides	provide	VBZ
cord-022353-q2k2krnm	174	13	sedation	sedation	NN
cord-022353-q2k2krnm	174	14	and	and	CC
cord-022353-q2k2krnm	174	15	analgesic	analgesic	JJ
cord-022353-q2k2krnm	174	16	for	for	IN
cord-022353-q2k2krnm	174	17	1	1	CD
cord-022353-q2k2krnm	174	18	-	-	SYM
cord-022353-q2k2krnm	174	19	2	2	CD
cord-022353-q2k2krnm	174	20	minutes	minute	NNS
cord-022353-q2k2krnm	174	21	and	and	CC
cord-022353-q2k2krnm	174	22	is	be	VBZ
cord-022353-q2k2krnm	174	23	an	an	DT
cord-022353-q2k2krnm	174	24	appropriate	appropriate	JJ
cord-022353-q2k2krnm	174	25	anesthetic	anesthetic	NN
cord-022353-q2k2krnm	174	26	for	for	IN
cord-022353-q2k2krnm	174	27	orbital	orbital	JJ
cord-022353-q2k2krnm	174	28	plexus	plexus	NN
cord-022353-q2k2krnm	174	29	bleeding	bleeding	NN
cord-022353-q2k2krnm	174	30	.	.	.
cord-022353-q2k2krnm	175	1	When	when	WRB
cord-022353-q2k2krnm	175	2	greater	great	JJR
cord-022353-q2k2krnm	175	3	volumes	volume	NNS
cord-022353-q2k2krnm	175	4	of	of	IN
cord-022353-q2k2krnm	175	5	blood	blood	NN
cord-022353-q2k2krnm	175	6	are	be	VBP
cord-022353-q2k2krnm	175	7	required	require	VBN
cord-022353-q2k2krnm	175	8	,	,	,
cord-022353-q2k2krnm	175	9	four	four	CD
cord-022353-q2k2krnm	175	10	collection	collection	NN
cord-022353-q2k2krnm	175	11	sites	site	NNS
cord-022353-q2k2krnm	175	12	can	can	MD
cord-022353-q2k2krnm	175	13	be	be	VB
cord-022353-q2k2krnm	175	14	used	use	VBN
cord-022353-q2k2krnm	175	15	that	that	WDT
cord-022353-q2k2krnm	175	16	require	require	VB
cord-022353-q2k2krnm	175	17	anesthesia	anesthesia	NN
cord-022353-q2k2krnm	175	18	and	and	CC
cord-022353-q2k2krnm	175	19	subsequent	subsequent	JJ
cord-022353-q2k2krnm	175	20	euthanasia	euthanasia	NN
cord-022353-q2k2krnm	175	21	of	of	IN
cord-022353-q2k2krnm	175	22	the	the	DT
cord-022353-q2k2krnm	175	23	mouse	mouse	NN
cord-022353-q2k2krnm	175	24	.	.	.
cord-022353-q2k2krnm	176	1	These	these	DT
cord-022353-q2k2krnm	176	2	sites	site	NNS
cord-022353-q2k2krnm	176	3	include	include	VBP
cord-022353-q2k2krnm	176	4	the	the	DT
cord-022353-q2k2krnm	176	5	jugular	jugular	NN
cord-022353-q2k2krnm	176	6	vein	vein	NN
cord-022353-q2k2krnm	176	7	(	(	-LRB-
cord-022353-q2k2krnm	176	8	Ambrus	Ambrus	NNP
cord-022353-q2k2krnm	176	9	et	et	NNP
cord-022353-q2k2krnm	176	10	al	al	NNP
cord-022353-q2k2krnm	176	11	.	.	NNP
cord-022353-q2k2krnm	176	12	1951	1951	CD
cord-022353-q2k2krnm	176	13	)	)	-RRB-
cord-022353-q2k2krnm	176	14	,	,	,
cord-022353-q2k2krnm	176	15	the	the	DT
cord-022353-q2k2krnm	176	16	abdominal	abdominal	JJ
cord-022353-q2k2krnm	176	17	aorta	aorta	NN
cord-022353-q2k2krnm	176	18	(	(	-LRB-
cord-022353-q2k2krnm	176	19	Lushbough	Lushbough	NNP
cord-022353-q2k2krnm	176	20	and	and	CC
cord-022353-q2k2krnm	176	21	Moline	Moline	NNP
cord-022353-q2k2krnm	176	22	1961	1961	CD
cord-022353-q2k2krnm	176	23	)	)	-RRB-
cord-022353-q2k2krnm	176	24	,	,	,
cord-022353-q2k2krnm	176	25	the	the	DT
cord-022353-q2k2krnm	176	26	brachial	brachial	JJ
cord-022353-q2k2krnm	176	27	artery	artery	NN
cord-022353-q2k2krnm	176	28	(	(	-LRB-
cord-022353-q2k2krnm	176	29	Young	Young	NNP
cord-022353-q2k2krnm	176	30	and	and	CC
cord-022353-q2k2krnm	176	31	Chambers	Chambers	NNP
cord-022353-q2k2krnm	176	32	1973	1973	CD
cord-022353-q2k2krnm	176	33	)	)	-RRB-
cord-022353-q2k2krnm	176	34	,	,	,
cord-022353-q2k2krnm	176	35	and	and	CC
cord-022353-q2k2krnm	176	36	the	the	DT
cord-022353-q2k2krnm	176	37	heart	heart	NN
cord-022353-q2k2krnm	176	38	(	(	-LRB-
cord-022353-q2k2krnm	176	39	Cubitt	Cubitt	NNP
cord-022353-q2k2krnm	176	40	and	and	CC
cord-022353-q2k2krnm	176	41	Barrett	Barrett	NNP
cord-022353-q2k2krnm	176	42	1978	1978	CD
cord-022353-q2k2krnm	176	43	;	;	:
cord-022353-q2k2krnm	176	44	Mitruka	Mitruka	NNP
cord-022353-q2k2krnm	176	45	and	and	CC
cord-022353-q2k2krnm	176	46	Rawnsley	Rawnsley	NNP
cord-022353-q2k2krnm	176	47	1977	1977	CD
cord-022353-q2k2krnm	176	48	)	)	-RRB-
cord-022353-q2k2krnm	176	49	.	.	.
cord-022353-q2k2krnm	177	1	Blood	blood	NN
cord-022353-q2k2krnm	177	2	collection	collection	NN
cord-022353-q2k2krnm	177	3	from	from	IN
cord-022353-q2k2krnm	177	4	a	a	DT
cord-022353-q2k2krnm	177	5	newborn	newborn	JJ
cord-022353-q2k2krnm	177	6	mouse	mouse	NN
cord-022353-q2k2krnm	177	7	can	can	MD
cord-022353-q2k2krnm	177	8	be	be	VB
cord-022353-q2k2krnm	177	9	accomplished	accomplish	VBN
cord-022353-q2k2krnm	177	10	by	by	IN
cord-022353-q2k2krnm	177	11	decapitation	decapitation	NN
cord-022353-q2k2krnm	177	12	.	.	.
cord-022353-q2k2krnm	178	1	Injection	injection	NN
cord-022353-q2k2krnm	178	2	of	of	IN
cord-022353-q2k2krnm	178	3	two	two	CD
cord-022353-q2k2krnm	178	4	units	unit	NNS
cord-022353-q2k2krnm	178	5	of	of	IN
cord-022353-q2k2krnm	178	6	heparin	heparin	NN
cord-022353-q2k2krnm	178	7	subcutaneously	subcutaneously	RB
cord-022353-q2k2krnm	178	8	several	several	JJ
cord-022353-q2k2krnm	178	9	minutes	minute	NNS
cord-022353-q2k2krnm	178	10	before	before	IN
cord-022353-q2k2krnm	178	11	decapitation	decapitation	NN
cord-022353-q2k2krnm	178	12	may	may	MD
cord-022353-q2k2krnm	178	13	allow	allow	VB
cord-022353-q2k2krnm	178	14	collection	collection	NN
cord-022353-q2k2krnm	178	15	of	of	IN
cord-022353-q2k2krnm	178	16	up	up	IN
cord-022353-q2k2krnm	178	17	to	to	TO
cord-022353-q2k2krnm	178	18	40	40	CD
cord-022353-q2k2krnm	178	19	~tl	~tl	VBN
cord-022353-q2k2krnm	178	20	of	of	IN
cord-022353-q2k2krnm	178	21	blood	blood	NN
cord-022353-q2k2krnm	178	22	(	(	-LRB-
cord-022353-q2k2krnm	178	23	20	20	CD
cord-022353-q2k2krnm	178	24	~tl	~tl	JJ
cord-022353-q2k2krnm	178	25	of	of	IN
cord-022353-q2k2krnm	178	26	plasma	plasma	NN
cord-022353-q2k2krnm	178	27	)	)	-RRB-
cord-022353-q2k2krnm	178	28	.	.	.
cord-022353-q2k2krnm	179	1	Although	although	IN
cord-022353-q2k2krnm	179	2	collection	collection	NN
cord-022353-q2k2krnm	179	3	of	of	IN
cord-022353-q2k2krnm	179	4	urine	urine	NN
cord-022353-q2k2krnm	179	5	is	be	VBZ
cord-022353-q2k2krnm	179	6	possible	possible	JJ
cord-022353-q2k2krnm	179	7	in	in	IN
cord-022353-q2k2krnm	179	8	mice	mouse	NNS
cord-022353-q2k2krnm	179	9	,	,	,
cord-022353-q2k2krnm	179	10	it	-PRON-	PRP
cord-022353-q2k2krnm	179	11	is	be	VBZ
cord-022353-q2k2krnm	179	12	impractical	impractical	JJ
cord-022353-q2k2krnm	179	13	due	due	IN
cord-022353-q2k2krnm	179	14	to	to	IN
cord-022353-q2k2krnm	179	15	anatomic	anatomic	JJ
cord-022353-q2k2krnm	179	16	and	and	CC
cord-022353-q2k2krnm	179	17	physiologic	physiologic	JJ
cord-022353-q2k2krnm	179	18	restrictions	restriction	NNS
cord-022353-q2k2krnm	179	19	.	.	.
cord-022353-q2k2krnm	180	1	The	the	DT
cord-022353-q2k2krnm	180	2	total	total	JJ
cord-022353-q2k2krnm	180	3	urinary	urinary	JJ
cord-022353-q2k2krnm	180	4	bladder	bladder	NN
cord-022353-q2k2krnm	180	5	volume	volume	NN
cord-022353-q2k2krnm	180	6	is	be	VBZ
cord-022353-q2k2krnm	180	7	less	less	JJR
cord-022353-q2k2krnm	180	8	than	than	IN
cord-022353-q2k2krnm	180	9	0.5	0.5	CD
cord-022353-q2k2krnm	180	10	ml	ml	NNS
cord-022353-q2k2krnm	180	11	,	,	,
cord-022353-q2k2krnm	180	12	and	and	CC
cord-022353-q2k2krnm	180	13	total	total	JJ
cord-022353-q2k2krnm	180	14	urinary	urinary	JJ
cord-022353-q2k2krnm	180	15	output	output	NN
cord-022353-q2k2krnm	180	16	per	per	IN
cord-022353-q2k2krnm	180	17	day	day	NN
cord-022353-q2k2krnm	180	18	is	be	VBZ
cord-022353-q2k2krnm	180	19	less	less	JJR
cord-022353-q2k2krnm	180	20	than	than	IN
cord-022353-q2k2krnm	180	21	2	2	CD
cord-022353-q2k2krnm	180	22	ml	ml	NN
cord-022353-q2k2krnm	181	1	(	(	-LRB-
cord-022353-q2k2krnm	181	2	Jung	Jung	NNP
cord-022353-q2k2krnm	181	3	et	et	NNP
cord-022353-q2k2krnm	181	4	al	al	NNP
cord-022353-q2k2krnm	181	5	.	.	NNP
cord-022353-q2k2krnm	181	6	2003	2003	CD
cord-022353-q2k2krnm	181	7	)	)	-RRB-
cord-022353-q2k2krnm	181	8	,	,	,
cord-022353-q2k2krnm	181	9	meaning	mean	VBG
cord-022353-q2k2krnm	181	10	that	that	IN
cord-022353-q2k2krnm	181	11	mice	mouse	NNS
cord-022353-q2k2krnm	181	12	frequently	frequently	RB
cord-022353-q2k2krnm	181	13	micturate	micturate	VBP
cord-022353-q2k2krnm	181	14	.	.	.
cord-022353-q2k2krnm	182	1	This	this	DT
cord-022353-q2k2krnm	182	2	restricts	restrict	VBZ
cord-022353-q2k2krnm	182	3	the	the	DT
cord-022353-q2k2krnm	182	4	amount	amount	NN
cord-022353-q2k2krnm	182	5	urine	urine	NN
cord-022353-q2k2krnm	182	6	that	that	WDT
cord-022353-q2k2krnm	182	7	can	can	MD
cord-022353-q2k2krnm	182	8	be	be	VB
cord-022353-q2k2krnm	182	9	collected	collect	VBN
cord-022353-q2k2krnm	182	10	at	at	IN
cord-022353-q2k2krnm	182	11	any	any	DT
cord-022353-q2k2krnm	182	12	one	one	CD
cord-022353-q2k2krnm	182	13	time	time	NN
cord-022353-q2k2krnm	182	14	point	point	NN
cord-022353-q2k2krnm	182	15	and	and	CC
cord-022353-q2k2krnm	182	16	,	,	,
cord-022353-q2k2krnm	182	17	therefore	therefore	RB
cord-022353-q2k2krnm	182	18	,	,	,
cord-022353-q2k2krnm	182	19	will	will	MD
cord-022353-q2k2krnm	182	20	also	also	RB
cord-022353-q2k2krnm	182	21	restrict	restrict	VB
cord-022353-q2k2krnm	182	22	the	the	DT
cord-022353-q2k2krnm	182	23	number	number	NN
cord-022353-q2k2krnm	182	24	of	of	IN
cord-022353-q2k2krnm	182	25	analytes	analyte	NNS
cord-022353-q2k2krnm	182	26	that	that	WDT
cord-022353-q2k2krnm	182	27	can	can	MD
cord-022353-q2k2krnm	182	28	be	be	VB
cord-022353-q2k2krnm	182	29	assessed	assess	VBN
cord-022353-q2k2krnm	182	30	from	from	IN
cord-022353-q2k2krnm	182	31	any	any	DT
cord-022353-q2k2krnm	182	32	one	one	CD
cord-022353-q2k2krnm	182	33	urine	urine	NN
cord-022353-q2k2krnm	182	34	sample	sample	NN
cord-022353-q2k2krnm	182	35	.	.	.
cord-022353-q2k2krnm	183	1	To	to	TO
cord-022353-q2k2krnm	183	2	be	be	VB
cord-022353-q2k2krnm	183	3	able	able	JJ
cord-022353-q2k2krnm	183	4	to	to	TO
cord-022353-q2k2krnm	183	5	collect	collect	VB
cord-022353-q2k2krnm	183	6	enough	enough	JJ
cord-022353-q2k2krnm	183	7	urine	urine	NN
cord-022353-q2k2krnm	183	8	for	for	IN
cord-022353-q2k2krnm	183	9	assessment	assessment	NN
cord-022353-q2k2krnm	183	10	from	from	IN
cord-022353-q2k2krnm	183	11	a	a	DT
cord-022353-q2k2krnm	183	12	single	single	JJ
cord-022353-q2k2krnm	183	13	live	live	JJ
cord-022353-q2k2krnm	183	14	mouse	mouse	NN
cord-022353-q2k2krnm	183	15	,	,	,
cord-022353-q2k2krnm	183	16	mice	mouse	NNS
cord-022353-q2k2krnm	183	17	can	can	MD
cord-022353-q2k2krnm	183	18	be	be	VB
cord-022353-q2k2krnm	183	19	placed	place	VBN
cord-022353-q2k2krnm	183	20	in	in	IN
cord-022353-q2k2krnm	183	21	a	a	DT
cord-022353-q2k2krnm	183	22	plastic	plastic	JJ
cord-022353-q2k2krnm	183	23	cage	cage	NN
cord-022353-q2k2krnm	183	24	without	without	IN
cord-022353-q2k2krnm	183	25	absorbent	absorbent	JJ
cord-022353-q2k2krnm	183	26	bedding	bedding	NN
cord-022353-q2k2krnm	183	27	material	material	NN
cord-022353-q2k2krnm	183	28	and	and	CC
cord-022353-q2k2krnm	183	29	urine	urine	NN
cord-022353-q2k2krnm	183	30	then	then	RB
cord-022353-q2k2krnm	183	31	collected	collect	VBN
cord-022353-q2k2krnm	183	32	from	from	IN
cord-022353-q2k2krnm	183	33	the	the	DT
cord-022353-q2k2krnm	183	34	bottom	bottom	NN
cord-022353-q2k2krnm	183	35	of	of	IN
cord-022353-q2k2krnm	183	36	the	the	DT
cord-022353-q2k2krnm	183	37	cage	cage	NN
cord-022353-q2k2krnm	183	38	after	after	IN
cord-022353-q2k2krnm	183	39	4	4	CD
cord-022353-q2k2krnm	183	40	-	-	SYM
cord-022353-q2k2krnm	183	41	6	6	CD
cord-022353-q2k2krnm	183	42	h.	h.	NN
cord-022353-q2k2krnm	184	1	However	however	RB
cord-022353-q2k2krnm	184	2	,	,	,
cord-022353-q2k2krnm	184	3	a	a	DT
cord-022353-q2k2krnm	184	4	disadvantage	disadvantage	NN
cord-022353-q2k2krnm	184	5	of	of	IN
cord-022353-q2k2krnm	184	6	this	this	DT
cord-022353-q2k2krnm	184	7	technique	technique	NN
cord-022353-q2k2krnm	184	8	is	be	VBZ
cord-022353-q2k2krnm	184	9	that	that	IN
cord-022353-q2k2krnm	184	10	the	the	DT
cord-022353-q2k2krnm	184	11	urine	urine	NN
cord-022353-q2k2krnm	184	12	is	be	VBZ
cord-022353-q2k2krnm	184	13	exposed	expose	VBN
cord-022353-q2k2krnm	184	14	to	to	IN
cord-022353-q2k2krnm	184	15	the	the	DT
cord-022353-q2k2krnm	184	16	contamination	contamination	NN
cord-022353-q2k2krnm	184	17	by	by	IN
cord-022353-q2k2krnm	184	18	feces	fece	NNS
cord-022353-q2k2krnm	184	19	and	and	CC
cord-022353-q2k2krnm	184	20	other	other	JJ
cord-022353-q2k2krnm	184	21	environmental	environmental	JJ
cord-022353-q2k2krnm	184	22	contaminants	contaminant	NNS
cord-022353-q2k2krnm	184	23	and	and	CC
cord-022353-q2k2krnm	184	24	organisms	organism	NNS
cord-022353-q2k2krnm	184	25	.	.	.
cord-022353-q2k2krnm	185	1	Pooled	pool	VBN
cord-022353-q2k2krnm	185	2	urine	urine	NN
cord-022353-q2k2krnm	185	3	samples	sample	NNS
cord-022353-q2k2krnm	185	4	collected	collect	VBN
cord-022353-q2k2krnm	185	5	from	from	IN
cord-022353-q2k2krnm	185	6	a	a	DT
cord-022353-q2k2krnm	185	7	group	group	NN
cord-022353-q2k2krnm	185	8	of	of	IN
cord-022353-q2k2krnm	185	9	live	live	JJ
cord-022353-q2k2krnm	185	10	mice	mouse	NNS
cord-022353-q2k2krnm	185	11	using	use	VBG
cord-022353-q2k2krnm	185	12	the	the	DT
cord-022353-q2k2krnm	185	13	same	same	JJ
cord-022353-q2k2krnm	185	14	technique	technique	NN
cord-022353-q2k2krnm	185	15	can	can	MD
cord-022353-q2k2krnm	185	16	increase	increase	VB
cord-022353-q2k2krnm	185	17	the	the	DT
cord-022353-q2k2krnm	185	18	total	total	JJ
cord-022353-q2k2krnm	185	19	amount	amount	NN
cord-022353-q2k2krnm	185	20	of	of	IN
cord-022353-q2k2krnm	185	21	urine	urine	NN
cord-022353-q2k2krnm	185	22	collected	collect	VBN
cord-022353-q2k2krnm	185	23	but	but	CC
cord-022353-q2k2krnm	185	24	will	will	MD
cord-022353-q2k2krnm	185	25	not	not	RB
cord-022353-q2k2krnm	185	26	allow	allow	VB
cord-022353-q2k2krnm	185	27	specific	specific	JJ
cord-022353-q2k2krnm	185	28	results	result	NNS
cord-022353-q2k2krnm	185	29	to	to	TO
cord-022353-q2k2krnm	185	30	be	be	VB
cord-022353-q2k2krnm	185	31	related	relate	VBN
cord-022353-q2k2krnm	185	32	back	back	RB
cord-022353-q2k2krnm	185	33	to	to	IN
cord-022353-q2k2krnm	185	34	specific	specific	JJ
cord-022353-q2k2krnm	185	35	individuals	individual	NNS
cord-022353-q2k2krnm	185	36	from	from	IN
cord-022353-q2k2krnm	185	37	that	that	DT
cord-022353-q2k2krnm	185	38	group	group	NN
cord-022353-q2k2krnm	185	39	.	.	.
cord-022353-q2k2krnm	186	1	Mice	mouse	NNS
cord-022353-q2k2krnm	186	2	removed	remove	VBD
cord-022353-q2k2krnm	186	3	quickly	quickly	RB
cord-022353-q2k2krnm	186	4	from	from	IN
cord-022353-q2k2krnm	186	5	their	-PRON-	PRP$
cord-022353-q2k2krnm	186	6	cage	cage	NN
cord-022353-q2k2krnm	186	7	and	and	CC
cord-022353-q2k2krnm	186	8	held	hold	VBD
cord-022353-q2k2krnm	186	9	over	over	IN
cord-022353-q2k2krnm	186	10	a	a	DT
cord-022353-q2k2krnm	186	11	piece	piece	NN
cord-022353-q2k2krnm	186	12	of	of	IN
cord-022353-q2k2krnm	186	13	parafilm	parafilm	NN
cord-022353-q2k2krnm	186	14	will	will	MD
cord-022353-q2k2krnm	186	15	frequently	frequently	RB
cord-022353-q2k2krnm	186	16	void	void	VB
cord-022353-q2k2krnm	186	17	and	and	CC
cord-022353-q2k2krnm	186	18	the	the	DT
cord-022353-q2k2krnm	186	19	parafilm	parafilm	NN
cord-022353-q2k2krnm	186	20	helps	help	VBZ
cord-022353-q2k2krnm	186	21	prevent	prevent	VB
cord-022353-q2k2krnm	186	22	the	the	DT
cord-022353-q2k2krnm	186	23	urine	urine	NN
cord-022353-q2k2krnm	186	24	from	from	IN
cord-022353-q2k2krnm	186	25	spreading	spread	VBG
cord-022353-q2k2krnm	186	26	.	.	.
cord-022353-q2k2krnm	187	1	Urine	urine	NN
cord-022353-q2k2krnm	187	2	can	can	MD
cord-022353-q2k2krnm	187	3	also	also	RB
cord-022353-q2k2krnm	187	4	be	be	VB
cord-022353-q2k2krnm	187	5	collected	collect	VBN
cord-022353-q2k2krnm	187	6	directly	directly	RB
cord-022353-q2k2krnm	187	7	from	from	IN
cord-022353-q2k2krnm	187	8	the	the	DT
cord-022353-q2k2krnm	187	9	urinary	urinary	JJ
cord-022353-q2k2krnm	187	10	bladder	bladder	NN
cord-022353-q2k2krnm	187	11	from	from	IN
cord-022353-q2k2krnm	187	12	mice	mouse	NNS
cord-022353-q2k2krnm	187	13	after	after	IN
cord-022353-q2k2krnm	187	14	euthanasia	euthanasia	NN
cord-022353-q2k2krnm	187	15	.	.	.
cord-022353-q2k2krnm	188	1	This	this	DT
cord-022353-q2k2krnm	188	2	technique	technique	NN
cord-022353-q2k2krnm	188	3	allows	allow	VBZ
cord-022353-q2k2krnm	188	4	for	for	IN
cord-022353-q2k2krnm	188	5	a	a	DT
cord-022353-q2k2krnm	188	6	sterile	sterile	JJ
cord-022353-q2k2krnm	188	7	sampling	sampling	NN
cord-022353-q2k2krnm	188	8	,	,	,
cord-022353-q2k2krnm	188	9	but	but	CC
cord-022353-q2k2krnm	188	10	the	the	DT
cord-022353-q2k2krnm	188	11	volume	volume	NN
cord-022353-q2k2krnm	188	12	that	that	WDT
cord-022353-q2k2krnm	188	13	can	can	MD
cord-022353-q2k2krnm	188	14	be	be	VB
cord-022353-q2k2krnm	188	15	collected	collect	VBN
cord-022353-q2k2krnm	188	16	is	be	VBZ
cord-022353-q2k2krnm	188	17	restricted	restrict	VBN
cord-022353-q2k2krnm	188	18	by	by	IN
cord-022353-q2k2krnm	188	19	total	total	JJ
cord-022353-q2k2krnm	188	20	urinary	urinary	JJ
cord-022353-q2k2krnm	188	21	bladder	bladder	NN
cord-022353-q2k2krnm	188	22	volume	volume	NN
cord-022353-q2k2krnm	188	23	(	(	-LRB-
cord-022353-q2k2krnm	188	24	0.5	0.5	CD
cord-022353-q2k2krnm	188	25	ml	ml	NN
cord-022353-q2k2krnm	188	26	)	)	-RRB-
cord-022353-q2k2krnm	188	27	.	.	.
cord-022353-q2k2krnm	189	1	Often	often	RB
cord-022353-q2k2krnm	189	2	,	,	,
cord-022353-q2k2krnm	189	3	the	the	DT
cord-022353-q2k2krnm	189	4	volume	volume	NN
cord-022353-q2k2krnm	189	5	is	be	VBZ
cord-022353-q2k2krnm	189	6	much	much	RB
cord-022353-q2k2krnm	189	7	less	less	JJR
cord-022353-q2k2krnm	189	8	because	because	IN
cord-022353-q2k2krnm	189	9	mice	mouse	NNS
cord-022353-q2k2krnm	189	10	typically	typically	RB
cord-022353-q2k2krnm	189	11	void	void	VBP
cord-022353-q2k2krnm	189	12	urine	urine	NN
cord-022353-q2k2krnm	189	13	from	from	IN
cord-022353-q2k2krnm	189	14	the	the	DT
cord-022353-q2k2krnm	189	15	urinary	urinary	JJ
cord-022353-q2k2krnm	189	16	bladder	bladder	NN
cord-022353-q2k2krnm	189	17	at	at	IN
cord-022353-q2k2krnm	189	18	the	the	DT
cord-022353-q2k2krnm	189	19	time	time	NN
cord-022353-q2k2krnm	189	20	of	of	IN
cord-022353-q2k2krnm	189	21	death	death	NN
cord-022353-q2k2krnm	189	22	.	.	.
cord-022353-q2k2krnm	190	1	Reference	reference	NN
cord-022353-q2k2krnm	190	2	ranges	range	NNS
cord-022353-q2k2krnm	190	3	refer	refer	VBP
cord-022353-q2k2krnm	190	4	to	to	IN
cord-022353-q2k2krnm	190	5	the	the	DT
cord-022353-q2k2krnm	190	6	range	range	NN
cord-022353-q2k2krnm	190	7	of	of	IN
cord-022353-q2k2krnm	190	8	an	an	DT
cord-022353-q2k2krnm	190	9	analyte	analyte	NN
cord-022353-q2k2krnm	190	10	or	or	CC
cord-022353-q2k2krnm	190	11	biomarker	biomarker	NN
cord-022353-q2k2krnm	190	12	in	in	IN
cord-022353-q2k2krnm	190	13	a	a	DT
cord-022353-q2k2krnm	190	14	population	population	NN
cord-022353-q2k2krnm	190	15	that	that	WDT
cord-022353-q2k2krnm	190	16	has	have	VBZ
cord-022353-q2k2krnm	190	17	not	not	RB
cord-022353-q2k2krnm	190	18	been	be	VBN
cord-022353-q2k2krnm	190	19	selected	select	VBN
cord-022353-q2k2krnm	190	20	for	for	IN
cord-022353-q2k2krnm	190	21	the	the	DT
cord-022353-q2k2krnm	190	22	presence	presence	NN
cord-022353-q2k2krnm	190	23	of	of	IN
cord-022353-q2k2krnm	190	24	disease	disease	NN
cord-022353-q2k2krnm	190	25	or	or	CC
cord-022353-q2k2krnm	190	26	abnormality	abnormality	NN
cord-022353-q2k2krnm	190	27	.	.	.
cord-022353-q2k2krnm	191	1	Reference	reference	NN
cord-022353-q2k2krnm	191	2	ranges	range	NNS
cord-022353-q2k2krnm	191	3	are	be	VBP
cord-022353-q2k2krnm	191	4	usually	usually	RB
cord-022353-q2k2krnm	191	5	generated	generate	VBN
cord-022353-q2k2krnm	191	6	from	from	IN
cord-022353-q2k2krnm	191	7	a	a	DT
cord-022353-q2k2krnm	191	8	large	large	JJ
cord-022353-q2k2krnm	191	9	number	number	NN
cord-022353-q2k2krnm	191	10	of	of	IN
cord-022353-q2k2krnm	191	11	individuals	individual	NNS
cord-022353-q2k2krnm	191	12	from	from	IN
cord-022353-q2k2krnm	191	13	a	a	DT
cord-022353-q2k2krnm	191	14	population	population	NN
cord-022353-q2k2krnm	191	15	,	,	,
cord-022353-q2k2krnm	191	16	so	so	RB
cord-022353-q2k2krnm	191	17	reference	reference	NN
cord-022353-q2k2krnm	191	18	ranges	range	NNS
cord-022353-q2k2krnm	191	19	for	for	IN
cord-022353-q2k2krnm	191	20	the	the	DT
cord-022353-q2k2krnm	191	21	same	same	JJ
cord-022353-q2k2krnm	191	22	analyte	analyte	NN
cord-022353-q2k2krnm	191	23	or	or	CC
cord-022353-q2k2krnm	191	24	biomarker	biomarker	NN
cord-022353-q2k2krnm	191	25	can	can	MD
cord-022353-q2k2krnm	191	26	vary	vary	VB
cord-022353-q2k2krnm	191	27	between	between	IN
cord-022353-q2k2krnm	191	28	two	two	CD
cord-022353-q2k2krnm	191	29	different	different	JJ
cord-022353-q2k2krnm	191	30	populations	population	NNS
cord-022353-q2k2krnm	191	31	.	.	.
cord-022353-q2k2krnm	192	1	Table	table	NN
cord-022353-q2k2krnm	192	2	6	6	CD
cord-022353-q2k2krnm	192	3	-	-	SYM
cord-022353-q2k2krnm	192	4	4	4	CD
cord-022353-q2k2krnm	192	5	lists	list	NNS
cord-022353-q2k2krnm	192	6	the	the	DT
cord-022353-q2k2krnm	192	7	reference	reference	NN
cord-022353-q2k2krnm	192	8	ranges	range	VBZ
cord-022353-q2k2krnm	192	9	for	for	IN
cord-022353-q2k2krnm	192	10	selected	select	VBN
cord-022353-q2k2krnm	192	11	analytes	analyte	NNS
cord-022353-q2k2krnm	192	12	in	in	IN
cord-022353-q2k2krnm	192	13	two	two	CD
cord-022353-q2k2krnm	192	14	inbred	inbred	JJ
cord-022353-q2k2krnm	192	15	strains	strain	NNS
cord-022353-q2k2krnm	192	16	and	and	CC
cord-022353-q2k2krnm	192	17	an	an	DT
cord-022353-q2k2krnm	192	18	outbred	outbred	JJ
cord-022353-q2k2krnm	192	19	stock	stock	NN
cord-022353-q2k2krnm	192	20	.	.	.
cord-022353-q2k2krnm	193	1	In	in	IN
cord-022353-q2k2krnm	193	2	some	some	DT
cord-022353-q2k2krnm	193	3	situations	situation	NNS
cord-022353-q2k2krnm	193	4	,	,	,
cord-022353-q2k2krnm	193	5	reference	reference	NN
cord-022353-q2k2krnm	193	6	ranges	range	NNS
cord-022353-q2k2krnm	193	7	that	that	WDT
cord-022353-q2k2krnm	193	8	have	have	VBP
cord-022353-q2k2krnm	193	9	been	be	VBN
cord-022353-q2k2krnm	193	10	published	publish	VBN
cord-022353-q2k2krnm	193	11	or	or	CC
cord-022353-q2k2krnm	193	12	generated	generate	VBN
cord-022353-q2k2krnm	193	13	by	by	IN
cord-022353-q2k2krnm	193	14	laboratories	laboratory	NNS
cord-022353-q2k2krnm	193	15	can	can	MD
cord-022353-q2k2krnm	193	16	not	not	RB
cord-022353-q2k2krnm	193	17	be	be	VB
cord-022353-q2k2krnm	193	18	relied	rely	VBN
cord-022353-q2k2krnm	193	19	on	on	IN
cord-022353-q2k2krnm	193	20	to	to	IN
cord-022353-q2k2krnm	193	21	accurately	accurately	RB
cord-022353-q2k2krnm	193	22	Some	some	DT
cord-022353-q2k2krnm	193	23	variables	variable	NNS
cord-022353-q2k2krnm	193	24	known	know	VBN
cord-022353-q2k2krnm	193	25	to	to	TO
cord-022353-q2k2krnm	193	26	adversely	adversely	RB
cord-022353-q2k2krnm	193	27	affect	affect	VB
cord-022353-q2k2krnm	193	28	the	the	DT
cord-022353-q2k2krnm	193	29	host	host	NN
cord-022353-q2k2krnm	193	30	include	include	VBP
cord-022353-q2k2krnm	193	31	environmental	environmental	JJ
cord-022353-q2k2krnm	193	32	factors	factor	NNS
cord-022353-q2k2krnm	193	33	,	,	,
cord-022353-q2k2krnm	193	34	pathogens	pathogen	NNS
cord-022353-q2k2krnm	193	35	,	,	,
cord-022353-q2k2krnm	193	36	and	and	CC
cord-022353-q2k2krnm	193	37	shipment	shipment	NN
cord-022353-q2k2krnm	193	38	.	.	.
cord-022353-q2k2krnm	194	1	In	in	IN
cord-022353-q2k2krnm	194	2	addition	addition	NN
cord-022353-q2k2krnm	194	3	,	,	,
cord-022353-q2k2krnm	194	4	nutrition	nutrition	NN
cord-022353-q2k2krnm	194	5	,	,	,
cord-022353-q2k2krnm	194	6	time	time	NN
cord-022353-q2k2krnm	194	7	of	of	IN
cord-022353-q2k2krnm	194	8	sample	sample	NN
cord-022353-q2k2krnm	194	9	collection	collection	NN
cord-022353-q2k2krnm	194	10	,	,	,
cord-022353-q2k2krnm	194	11	and	and	CC
cord-022353-q2k2krnm	194	12	storage	storage	NN
cord-022353-q2k2krnm	194	13	techniques	technique	NNS
cord-022353-q2k2krnm	194	14	may	may	MD
cord-022353-q2k2krnm	194	15	all	all	RB
cord-022353-q2k2krnm	194	16	contribute	contribute	VB
cord-022353-q2k2krnm	194	17	to	to	IN
cord-022353-q2k2krnm	194	18	variability	variability	NN
cord-022353-q2k2krnm	194	19	.	.	.
cord-022353-q2k2krnm	195	1	Age	age	NN
cord-022353-q2k2krnm	195	2	has	have	VBZ
cord-022353-q2k2krnm	195	3	an	an	DT
cord-022353-q2k2krnm	195	4	effect	effect	NN
cord-022353-q2k2krnm	195	5	on	on	IN
cord-022353-q2k2krnm	195	6	analytes	analyte	NNS
cord-022353-q2k2krnm	195	7	in	in	IN
cord-022353-q2k2krnm	195	8	the	the	DT
cord-022353-q2k2krnm	195	9	mouse	mouse	NN
cord-022353-q2k2krnm	195	10	.	.	.
cord-022353-q2k2krnm	196	1	In	in	IN
cord-022353-q2k2krnm	196	2	an	an	DT
cord-022353-q2k2krnm	196	3	early	early	JJ
cord-022353-q2k2krnm	196	4	study	study	NN
cord-022353-q2k2krnm	196	5	,	,	,
cord-022353-q2k2krnm	196	6	Barrett	Barrett	NNP
cord-022353-q2k2krnm	196	7	et	et	NNP
cord-022353-q2k2krnm	196	8	al	al	NNP
cord-022353-q2k2krnm	196	9	.	.	.
cord-022353-q2k2krnm	197	1	(	(	-LRB-
cord-022353-q2k2krnm	197	2	1975	1975	CD
cord-022353-q2k2krnm	197	3	)	)	-RRB-
cord-022353-q2k2krnm	197	4	found	find	VBD
cord-022353-q2k2krnm	197	5	that	that	IN
cord-022353-q2k2krnm	197	6	serum	serum	NN
cord-022353-q2k2krnm	197	7	calcium	calcium	NN
cord-022353-q2k2krnm	197	8	levels	level	NNS
cord-022353-q2k2krnm	197	9	in	in	IN
cord-022353-q2k2krnm	197	10	4-monthold	4-monthold	CD
cord-022353-q2k2krnm	198	1	C3H	C3H	NNP
cord-022353-q2k2krnm	198	2	/	/	SYM
cord-022353-q2k2krnm	198	3	Fg	Fg	NNP
cord-022353-q2k2krnm	198	4	and	and	CC
cord-022353-q2k2krnm	198	5	A	A	NNP
cord-022353-q2k2krnm	199	1	/Fg	/Fg	NNP
cord-022353-q2k2krnm	199	2	inbred	inbred	JJ
cord-022353-q2k2krnm	199	3	mice	mouse	NNS
cord-022353-q2k2krnm	199	4	were	be	VBD
cord-022353-q2k2krnm	199	5	significant	significant	JJ
cord-022353-q2k2krnm	199	6	higher	high	JJR
cord-022353-q2k2krnm	199	7	than	than	IN
cord-022353-q2k2krnm	199	8	7-month	7-month	JJ
cord-022353-q2k2krnm	199	9	-	-	HYPH
cord-022353-q2k2krnm	199	10	old	old	JJ
cord-022353-q2k2krnm	199	11	mice	mouse	NNS
cord-022353-q2k2krnm	199	12	of	of	IN
cord-022353-q2k2krnm	199	13	the	the	DT
cord-022353-q2k2krnm	199	14	same	same	JJ
cord-022353-q2k2krnm	199	15	strains	strain	NNS
cord-022353-q2k2krnm	199	16	.	.	.
cord-022353-q2k2krnm	200	1	More	more	RBR
cord-022353-q2k2krnm	200	2	recent	recent	JJ
cord-022353-q2k2krnm	200	3	and	and	CC
cord-022353-q2k2krnm	200	4	more	more	RBR
cord-022353-q2k2krnm	200	5	comprehensive	comprehensive	JJ
cord-022353-q2k2krnm	200	6	analyses	analysis	NNS
cord-022353-q2k2krnm	200	7	completed	complete	VBN
cord-022353-q2k2krnm	200	8	by	by	IN
cord-022353-q2k2krnm	200	9	Loeb	Loeb	NNP
cord-022353-q2k2krnm	200	10	et	et	NNP
cord-022353-q2k2krnm	200	11	al	al	NNP
cord-022353-q2k2krnm	200	12	.	.	.
cord-022353-q2k2krnm	201	1	(	(	-LRB-
cord-022353-q2k2krnm	201	2	1996	1996	CD
cord-022353-q2k2krnm	201	3	)	)	-RRB-
cord-022353-q2k2krnm	201	4	reinforces	reinforce	VBZ
cord-022353-q2k2krnm	201	5	the	the	DT
cord-022353-q2k2krnm	201	6	effect	effect	NN
cord-022353-q2k2krnm	201	7	that	that	WDT
cord-022353-q2k2krnm	201	8	age	age	NN
cord-022353-q2k2krnm	201	9	has	have	VBZ
cord-022353-q2k2krnm	201	10	on	on	IN
cord-022353-q2k2krnm	201	11	clinical	clinical	JJ
cord-022353-q2k2krnm	201	12	chemistry	chemistry	NN
cord-022353-q2k2krnm	201	13	parameters	parameter	NNS
cord-022353-q2k2krnm	201	14	in	in	IN
cord-022353-q2k2krnm	201	15	five	five	CD
cord-022353-q2k2krnm	201	16	inbred	inbred	JJ
cord-022353-q2k2krnm	201	17	strains	strain	NNS
cord-022353-q2k2krnm	201	18	and	and	CC
cord-022353-q2k2krnm	201	19	two	two	CD
cord-022353-q2k2krnm	201	20	F1	f1	NN
cord-022353-q2k2krnm	201	21	hybrids	hybrid	NNS
cord-022353-q2k2krnm	201	22	,	,	,
cord-022353-q2k2krnm	201	23	including	include	VBG
cord-022353-q2k2krnm	201	24	serum	serum	NN
cord-022353-q2k2krnm	201	25	protein	protein	NN
cord-022353-q2k2krnm	201	26	.	.	.
cord-022353-q2k2krnm	202	1	The	the	DT
cord-022353-q2k2krnm	202	2	effect	effect	NN
cord-022353-q2k2krnm	202	3	sex	sex	NN
cord-022353-q2k2krnm	202	4	has	have	VBZ
cord-022353-q2k2krnm	202	5	on	on	IN
cord-022353-q2k2krnm	202	6	chemistry	chemistry	NN
cord-022353-q2k2krnm	202	7	parameters	parameter	NNS
cord-022353-q2k2krnm	202	8	is	be	VBZ
cord-022353-q2k2krnm	202	9	most	most	RBS
cord-022353-q2k2krnm	202	10	demonstrable	demonstrable	JJ
cord-022353-q2k2krnm	202	11	with	with	IN
cord-022353-q2k2krnm	202	12	sex	sex	NN
cord-022353-q2k2krnm	202	13	hormones	hormone	NNS
cord-022353-q2k2krnm	202	14	,	,	,
cord-022353-q2k2krnm	202	15	including	include	VBG
cord-022353-q2k2krnm	202	16	follicle	follicle	NN
cord-022353-q2k2krnm	202	17	-	-	HYPH
cord-022353-q2k2krnm	202	18	stimulating	stimulate	VBG
cord-022353-q2k2krnm	202	19	hormone	hormone	NN
cord-022353-q2k2krnm	202	20	(	(	-LRB-
cord-022353-q2k2krnm	202	21	FSH	FSH	NNP
cord-022353-q2k2krnm	202	22	)	)	-RRB-
cord-022353-q2k2krnm	202	23	,	,	,
cord-022353-q2k2krnm	202	24	luteinizing	luteinize	VBG
cord-022353-q2k2krnm	202	25	hormone	hormone	NN
cord-022353-q2k2krnm	202	26	(	(	-LRB-
cord-022353-q2k2krnm	202	27	LH	LH	NNP
cord-022353-q2k2krnm	202	28	)	)	-RRB-
cord-022353-q2k2krnm	202	29	,	,	,
cord-022353-q2k2krnm	202	30	and	and	CC
cord-022353-q2k2krnm	202	31	progesterone	progesterone	NN
cord-022353-q2k2krnm	202	32	.	.	.
cord-022353-q2k2krnm	203	1	Table	table	NN
cord-022353-q2k2krnm	203	2	6	6	CD
cord-022353-q2k2krnm	203	3	-3	-3	NNP
cord-022353-q2k2krnm	203	4	illustrates	illustrate	VBZ
cord-022353-q2k2krnm	203	5	these	these	DT
cord-022353-q2k2krnm	203	6	differences	difference	NNS
cord-022353-q2k2krnm	203	7	between	between	IN
cord-022353-q2k2krnm	203	8	male	male	JJ
cord-022353-q2k2krnm	203	9	and	and	CC
cord-022353-q2k2krnm	203	10	female	female	JJ
cord-022353-q2k2krnm	203	11	mice	mouse	NNS
cord-022353-q2k2krnm	203	12	,	,	,
cord-022353-q2k2krnm	203	13	and	and	CC
cord-022353-q2k2krnm	203	14	between	between	IN
cord-022353-q2k2krnm	203	15	female	female	JJ
cord-022353-q2k2krnm	203	16	mice	mouse	NNS
cord-022353-q2k2krnm	203	17	in	in	IN
cord-022353-q2k2krnm	203	18	estrus	estrus	NN
cord-022353-q2k2krnm	203	19	and	and	CC
cord-022353-q2k2krnm	203	20	out	out	IN
cord-022353-q2k2krnm	203	21	of	of	IN
cord-022353-q2k2krnm	203	22	estrus	estrus	NN
cord-022353-q2k2krnm	203	23	.	.	.
cord-022353-q2k2krnm	204	1	Strain	strain	NN
cord-022353-q2k2krnm	204	2	-	-	HYPH
cord-022353-q2k2krnm	204	3	associated	associate	VBN
cord-022353-q2k2krnm	204	4	changes	change	NNS
cord-022353-q2k2krnm	204	5	appearing	appear	VBG
cord-022353-q2k2krnm	204	6	in	in	IN
cord-022353-q2k2krnm	204	7	healthy	healthy	JJ
cord-022353-q2k2krnm	204	8	animals	animal	NNS
cord-022353-q2k2krnm	204	9	have	have	VBP
cord-022353-q2k2krnm	204	10	been	be	VBN
cord-022353-q2k2krnm	204	11	documented	document	VBN
cord-022353-q2k2krnm	204	12	for	for	IN
cord-022353-q2k2krnm	204	13	complement	complement	JJ
cord-022353-q2k2krnm	204	14	components	component	NNS
cord-022353-q2k2krnm	204	15	(	(	-LRB-
cord-022353-q2k2krnm	204	16	Goldman	Goldman	NNP
cord-022353-q2k2krnm	204	17	and	and	CC
cord-022353-q2k2krnm	204	18	Goldman	Goldman	NNP
cord-022353-q2k2krnm	204	19	1976	1976	CD
cord-022353-q2k2krnm	204	20	)	)	-RRB-
cord-022353-q2k2krnm	204	21	,	,	,
cord-022353-q2k2krnm	204	22	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	204	23	(	(	-LRB-
cord-022353-q2k2krnm	204	24	Dunnington	Dunnington	NNP
cord-022353-q2k2krnm	204	25	et	et	FW
cord-022353-q2k2krnm	204	26	al	al	NNP
cord-022353-q2k2krnm	204	27	.	.	NNP
cord-022353-q2k2krnm	204	28	1981	1981	CD
cord-022353-q2k2krnm	204	29	;	;	:
cord-022353-q2k2krnm	204	30	Meade	Meade	NNP
cord-022353-q2k2krnm	204	31	and	and	CC
cord-022353-q2k2krnm	204	32	Gore	Gore	NNP
cord-022353-q2k2krnm	204	33	1982	1982	CD
cord-022353-q2k2krnm	204	34	)	)	-RRB-
cord-022353-q2k2krnm	204	35	,	,	,
cord-022353-q2k2krnm	204	36	testosterone	testosterone	NN
cord-022353-q2k2krnm	204	37	(	(	-LRB-
cord-022353-q2k2krnm	204	38	Ivanyi	Ivanyi	NNP
cord-022353-q2k2krnm	204	39	et	et	NNP
cord-022353-q2k2krnm	204	40	al	al	NNP
cord-022353-q2k2krnm	204	41	.	.	.
cord-022353-q2k2krnm	204	42	1972	1972	CD
cord-022353-q2k2krnm	204	43	)	)	-RRB-
cord-022353-q2k2krnm	204	44	,	,	,
cord-022353-q2k2krnm	204	45	cortisol	cortisol	NN
cord-022353-q2k2krnm	204	46	-	-	HYPH
cord-022353-q2k2krnm	204	47	binding	bind	VBG
cord-022353-q2k2krnm	204	48	protein	protein	NN
cord-022353-q2k2krnm	204	49	(	(	-LRB-
cord-022353-q2k2krnm	204	50	Goldman	Goldman	NNP
cord-022353-q2k2krnm	204	51	et	et	NNP
cord-022353-q2k2krnm	204	52	al	al	NNP
cord-022353-q2k2krnm	204	53	.	.	NNP
cord-022353-q2k2krnm	204	54	1977	1977	CD
cord-022353-q2k2krnm	204	55	)	)	-RRB-
cord-022353-q2k2krnm	204	56	,	,	,
cord-022353-q2k2krnm	204	57	and	and	CC
cord-022353-q2k2krnm	204	58	serum	serum	NN
cord-022353-q2k2krnm	204	59	protein	protein	NN
cord-022353-q2k2krnm	204	60	(	(	-LRB-
cord-022353-q2k2krnm	204	61	Borovkov	Borovkov	NNP
cord-022353-q2k2krnm	204	62	and	and	CC
cord-022353-q2k2krnm	204	63	Svirdov	Svirdov	NNP
cord-022353-q2k2krnm	204	64	1975	1975	CD
cord-022353-q2k2krnm	204	65	;	;	:
cord-022353-q2k2krnm	204	66	Loeb	Loeb	NNP
cord-022353-q2k2krnm	204	67	1997	1997	CD
cord-022353-q2k2krnm	204	68	)	)	-RRB-
cord-022353-q2k2krnm	204	69	.	.	.
cord-022353-q2k2krnm	205	1	Cyclic	cyclic	JJ
cord-022353-q2k2krnm	205	2	biorhythms	biorhythm	NNS
cord-022353-q2k2krnm	205	3	,	,	,
cord-022353-q2k2krnm	205	4	whether	whether	IN
cord-022353-q2k2krnm	205	5	circadian	circadian	NN
cord-022353-q2k2krnm	205	6	or	or	CC
cord-022353-q2k2krnm	205	7	ultradian	ultradian	JJ
cord-022353-q2k2krnm	205	8	,	,	,
cord-022353-q2k2krnm	205	9	influence	influence	NN
cord-022353-q2k2krnm	205	10	blood	blood	NN
cord-022353-q2k2krnm	205	11	levels	level	NNS
cord-022353-q2k2krnm	205	12	of	of	IN
cord-022353-q2k2krnm	205	13	various	various	JJ
cord-022353-q2k2krnm	205	14	analytes	analyte	NNS
cord-022353-q2k2krnm	205	15	in	in	IN
cord-022353-q2k2krnm	205	16	mice	mouse	NNS
cord-022353-q2k2krnm	205	17	.	.	.
cord-022353-q2k2krnm	206	1	Blood	blood	NN
cord-022353-q2k2krnm	206	2	levels	level	NNS
cord-022353-q2k2krnm	206	3	of	of	IN
cord-022353-q2k2krnm	206	4	adrenocorticotropic	adrenocorticotropic	JJ
cord-022353-q2k2krnm	206	5	hormone	hormone	NN
cord-022353-q2k2krnm	206	6	(	(	-LRB-
cord-022353-q2k2krnm	206	7	ACTH	ACTH	NNP
cord-022353-q2k2krnm	206	8	)	)	-RRB-
cord-022353-q2k2krnm	206	9	,	,	,
cord-022353-q2k2krnm	206	10	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	206	11	,	,	,
cord-022353-q2k2krnm	206	12	growth	growth	NN
cord-022353-q2k2krnm	206	13	hormone	hormone	NN
cord-022353-q2k2krnm	206	14	(	(	-LRB-
cord-022353-q2k2krnm	206	15	GH	GH	NNP
cord-022353-q2k2krnm	206	16	)	)	-RRB-
cord-022353-q2k2krnm	206	17	,	,	,
cord-022353-q2k2krnm	206	18	and	and	CC
cord-022353-q2k2krnm	206	19	LH	LH	NNP
cord-022353-q2k2krnm	206	20	may	may	MD
cord-022353-q2k2krnm	206	21	peak	peak	VB
cord-022353-q2k2krnm	206	22	one	one	CD
cord-022353-q2k2krnm	206	23	or	or	CC
cord-022353-q2k2krnm	206	24	more	more	JJR
cord-022353-q2k2krnm	206	25	times	time	NNS
cord-022353-q2k2krnm	206	26	daily	daily	RB
cord-022353-q2k2krnm	206	27	,	,	,
cord-022353-q2k2krnm	206	28	and	and	CC
cord-022353-q2k2krnm	206	29	thus	thus	RB
cord-022353-q2k2krnm	206	30	special	special	JJ
cord-022353-q2k2krnm	206	31	attention	attention	NN
cord-022353-q2k2krnm	206	32	must	must	MD
cord-022353-q2k2krnm	206	33	be	be	VB
cord-022353-q2k2krnm	206	34	given	give	VBN
cord-022353-q2k2krnm	206	35	to	to	IN
cord-022353-q2k2krnm	206	36	both	both	CC
cord-022353-q2k2krnm	206	37	the	the	DT
cord-022353-q2k2krnm	206	38	time	time	NN
cord-022353-q2k2krnm	206	39	of	of	IN
cord-022353-q2k2krnm	206	40	collection	collection	NN
cord-022353-q2k2krnm	206	41	and	and	CC
cord-022353-q2k2krnm	206	42	the	the	DT
cord-022353-q2k2krnm	206	43	order	order	NN
cord-022353-q2k2krnm	206	44	of	of	IN
cord-022353-q2k2krnm	206	45	sampling	sampling	NN
cord-022353-q2k2krnm	206	46	individuals	individual	NNS
cord-022353-q2k2krnm	206	47	between	between	IN
cord-022353-q2k2krnm	206	48	groups	group	NNS
cord-022353-q2k2krnm	206	49	if	if	IN
cord-022353-q2k2krnm	206	50	between	between	IN
cord-022353-q2k2krnm	206	51	-	-	HYPH
cord-022353-q2k2krnm	206	52	group	group	NN
cord-022353-q2k2krnm	206	53	comparisons	comparison	NNS
cord-022353-q2k2krnm	206	54	are	be	VBP
cord-022353-q2k2krnm	206	55	to	to	TO
cord-022353-q2k2krnm	206	56	be	be	VB
cord-022353-q2k2krnm	206	57	made	make	VBN
cord-022353-q2k2krnm	206	58	(	(	-LRB-
cord-022353-q2k2krnm	206	59	Loeb	Loeb	NNP
cord-022353-q2k2krnm	206	60	1997	1997	CD
cord-022353-q2k2krnm	206	61	)	)	-RRB-
cord-022353-q2k2krnm	206	62	.	.	.
cord-022353-q2k2krnm	207	1	The	the	DT
cord-022353-q2k2krnm	207	2	degree	degree	NN
cord-022353-q2k2krnm	207	3	of	of	IN
cord-022353-q2k2krnm	207	4	hydration	hydration	NN
cord-022353-q2k2krnm	207	5	,	,	,
cord-022353-q2k2krnm	207	6	exposure	exposure	NN
cord-022353-q2k2krnm	207	7	to	to	IN
cord-022353-q2k2krnm	207	8	noise	noise	NN
cord-022353-q2k2krnm	207	9	,	,	,
cord-022353-q2k2krnm	207	10	degree	degree	NN
cord-022353-q2k2krnm	207	11	of	of	IN
cord-022353-q2k2krnm	207	12	confinement	confinement	NN
cord-022353-q2k2krnm	207	13	,	,	,
cord-022353-q2k2krnm	207	14	and	and	CC
cord-022353-q2k2krnm	207	15	environmental	environmental	JJ
cord-022353-q2k2krnm	207	16	temperatures	temperature	NNS
cord-022353-q2k2krnm	207	17	has	have	VBZ
cord-022353-q2k2krnm	207	18	all	all	DT
cord-022353-q2k2krnm	207	19	been	be	VBN
cord-022353-q2k2krnm	207	20	shown	show	VBN
cord-022353-q2k2krnm	207	21	to	to	TO
cord-022353-q2k2krnm	207	22	affect	affect	VB
cord-022353-q2k2krnm	207	23	serum	serum	NN
cord-022353-q2k2krnm	207	24	chemistry	chemistry	NN
cord-022353-q2k2krnm	207	25	analytes	analyte	NNS
cord-022353-q2k2krnm	207	26	(	(	-LRB-
cord-022353-q2k2krnm	207	27	Quimby	Quimby	NNP
cord-022353-q2k2krnm	207	28	1999b	1999b	CD
cord-022353-q2k2krnm	207	29	)	)	-RRB-
cord-022353-q2k2krnm	207	30	.	.	.
cord-022353-q2k2krnm	208	1	Diet	Diet	NNP
cord-022353-q2k2krnm	208	2	is	be	VBZ
cord-022353-q2k2krnm	208	3	known	know	VBN
cord-022353-q2k2krnm	208	4	to	to	TO
cord-022353-q2k2krnm	208	5	influence	influence	VB
cord-022353-q2k2krnm	208	6	the	the	DT
cord-022353-q2k2krnm	208	7	blood	blood	NN
cord-022353-q2k2krnm	208	8	levels	level	NNS
cord-022353-q2k2krnm	208	9	of	of	IN
cord-022353-q2k2krnm	208	10	many	many	JJ
cord-022353-q2k2krnm	208	11	analytes	analyte	NNS
cord-022353-q2k2krnm	208	12	.	.	.
cord-022353-q2k2krnm	209	1	Perhaps	perhaps	RB
cord-022353-q2k2krnm	209	2	the	the	DT
cord-022353-q2k2krnm	209	3	best	well	RBS
cord-022353-q2k2krnm	209	4	studied	study	VBN
cord-022353-q2k2krnm	209	5	is	be	VBZ
cord-022353-q2k2krnm	209	6	the	the	DT
cord-022353-q2k2krnm	209	7	effect	effect	NN
cord-022353-q2k2krnm	209	8	of	of	IN
cord-022353-q2k2krnm	209	9	atherogenic	atherogenic	JJ
cord-022353-q2k2krnm	209	10	diets	diet	NNS
cord-022353-q2k2krnm	209	11	on	on	IN
cord-022353-q2k2krnm	209	12	serum	serum	NN
cord-022353-q2k2krnm	209	13	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	209	14	.	.	.
cord-022353-q2k2krnm	210	1	Similarly	similarly	RB
cord-022353-q2k2krnm	210	2	,	,	,
cord-022353-q2k2krnm	210	3	significant	significant	JJ
cord-022353-q2k2krnm	210	4	differences	difference	NNS
cord-022353-q2k2krnm	210	5	in	in	IN
cord-022353-q2k2krnm	210	6	both	both	DT
cord-022353-q2k2krnm	210	7	serum	serum	NN
cord-022353-q2k2krnm	210	8	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	210	9	and	and	CC
cord-022353-q2k2krnm	210	10	urea	urea	NN
cord-022353-q2k2krnm	210	11	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	210	12	are	be	VBP
cord-022353-q2k2krnm	210	13	seen	see	VBN
cord-022353-q2k2krnm	210	14	in	in	IN
cord-022353-q2k2krnm	210	15	mice	mouse	NNS
cord-022353-q2k2krnm	210	16	maindetermine	maindetermine	NN
cord-022353-q2k2krnm	210	17	the	the	DT
cord-022353-q2k2krnm	210	18	presence	presence	NN
cord-022353-q2k2krnm	210	19	or	or	CC
cord-022353-q2k2krnm	210	20	absence	absence	NN
cord-022353-q2k2krnm	210	21	of	of	IN
cord-022353-q2k2krnm	210	22	disease	disease	NN
cord-022353-q2k2krnm	210	23	or	or	CC
cord-022353-q2k2krnm	210	24	abnormality	abnormality	NN
cord-022353-q2k2krnm	210	25	,	,	,
cord-022353-q2k2krnm	210	26	tained	taine	VBN
cord-022353-q2k2krnm	210	27	on	on	IN
cord-022353-q2k2krnm	210	28	a	a	DT
cord-022353-q2k2krnm	210	29	semipurified	semipurifie	VBN
cord-022353-q2k2krnm	210	30	(	(	-LRB-
cord-022353-q2k2krnm	210	31	AIN-76	AIN-76	NNP
cord-022353-q2k2krnm	210	32	)	)	-RRB-
cord-022353-q2k2krnm	210	33	diet	diet	NN
cord-022353-q2k2krnm	210	34	.	.	.
cord-022353-q2k2krnm	211	1	The	the	DT
cord-022353-q2k2krnm	211	2	mouse	mouse	NN
cord-022353-q2k2krnm	211	3	is	be	VBZ
cord-022353-q2k2krnm	211	4	unique	unique	JJ
cord-022353-q2k2krnm	211	5	These	these	DT
cord-022353-q2k2krnm	211	6	situations	situation	NNS
cord-022353-q2k2krnm	211	7	include	include	VBP
cord-022353-q2k2krnm	211	8	evaluating	evaluate	VBG
cord-022353-q2k2krnm	211	9	analytes	analyte	NNS
cord-022353-q2k2krnm	211	10	and	and	CC
cord-022353-q2k2krnm	211	11	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	211	12	in	in	IN
cord-022353-q2k2krnm	211	13	J	J	NNP
cord-022353-q2k2krnm	211	14	among	among	IN
cord-022353-q2k2krnm	211	15	mammals	mammal	NNS
cord-022353-q2k2krnm	211	16	because	because	IN
cord-022353-q2k2krnm	211	17	murine	murine	JJ
cord-022353-q2k2krnm	211	18	muscles	muscle	NNS
cord-022353-q2k2krnm	211	19	do	do	VBP
cord-022353-q2k2krnm	211	20	not	not	RB
cord-022353-q2k2krnm	211	21	contain	contain	VB
cord-022353-q2k2krnm	211	22	transgenic	transgenic	JJ
cord-022353-q2k2krnm	211	23	and	and	CC
cord-022353-q2k2krnm	211	24	KO	KO	NNP
cord-022353-q2k2krnm	211	25	mouse	mouse	NN
cord-022353-q2k2krnm	211	26	populations	population	NNS
cord-022353-q2k2krnm	211	27	(	(	-LRB-
cord-022353-q2k2krnm	211	28	especially	especially	RB
cord-022353-q2k2krnm	211	29	in	in	IN
cord-022353-q2k2krnm	211	30	experiments	experiment	NNS
cord-022353-q2k2krnm	211	31	in	in	IN
cord-022353-q2k2krnm	211	32	which	which	WDT
cord-022353-q2k2krnm	211	33	population	population	NN
cord-022353-q2k2krnm	211	34	sizes	size	NNS
cord-022353-q2k2krnm	211	35	are	be	VBP
cord-022353-q2k2krnm	211	36	small	small	JJ
cord-022353-q2k2krnm	211	37	)	)	-RRB-
cord-022353-q2k2krnm	211	38	and	and	CC
cord-022353-q2k2krnm	211	39	evaluating	evaluate	VBG
cord-022353-q2k2krnm	211	40	certain	certain	JJ
cord-022353-q2k2krnm	211	41	analytes	analyte	NNS
cord-022353-q2k2krnm	211	42	and	and	CC
cord-022353-q2k2krnm	211	43	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	211	44	(	(	-LRB-
cord-022353-q2k2krnm	211	45	such	such	JJ
cord-022353-q2k2krnm	211	46	as	as	IN
cord-022353-q2k2krnm	211	47	those	those	DT
cord-022353-q2k2krnm	211	48	assessing	assess	VBG
cord-022353-q2k2krnm	211	49	immune	immune	JJ
cord-022353-q2k2krnm	211	50	function	function	NN
cord-022353-q2k2krnm	211	51	)	)	-RRB-
cord-022353-q2k2krnm	211	52	.	.	.
cord-022353-q2k2krnm	212	1	Instead	instead	RB
cord-022353-q2k2krnm	212	2	,	,	,
cord-022353-q2k2krnm	212	3	baseline	baseline	JJ
cord-022353-q2k2krnm	212	4	data	datum	NNS
cord-022353-q2k2krnm	212	5	compiled	compile	VBN
cord-022353-q2k2krnm	212	6	from	from	IN
cord-022353-q2k2krnm	212	7	controls	control	NNS
cord-022353-q2k2krnm	212	8	(	(	-LRB-
cord-022353-q2k2krnm	212	9	the	the	DT
cord-022353-q2k2krnm	212	10	population	population	NN
cord-022353-q2k2krnm	212	11	of	of	IN
cord-022353-q2k2krnm	212	12	wild	wild	JJ
cord-022353-q2k2krnm	212	13	-	-	HYPH
cord-022353-q2k2krnm	212	14	type	type	NN
cord-022353-q2k2krnm	212	15	mice	mouse	NNS
cord-022353-q2k2krnm	212	16	from	from	IN
cord-022353-q2k2krnm	212	17	which	which	WDT
cord-022353-q2k2krnm	212	18	the	the	DT
cord-022353-q2k2krnm	212	19	transgenic	transgenic	JJ
cord-022353-q2k2krnm	212	20	and	and	CC
cord-022353-q2k2krnm	212	21	KO	KO	NNP
cord-022353-q2k2krnm	212	22	mice	mouse	NNS
cord-022353-q2k2krnm	212	23	were	be	VBD
cord-022353-q2k2krnm	212	24	derived	derive	VBN
cord-022353-q2k2krnm	212	25	from	from	IN
cord-022353-q2k2krnm	212	26	)	)	-RRB-
cord-022353-q2k2krnm	212	27	should	should	MD
cord-022353-q2k2krnm	212	28	be	be	VB
cord-022353-q2k2krnm	212	29	used	use	VBN
cord-022353-q2k2krnm	212	30	.	.	.
cord-022353-q2k2krnm	213	1	The	the	DT
cord-022353-q2k2krnm	213	2	usefulness	usefulness	NN
cord-022353-q2k2krnm	213	3	of	of	IN
cord-022353-q2k2krnm	213	4	compiled	compile	VBN
cord-022353-q2k2krnm	213	5	baseline	baseline	JJ
cord-022353-q2k2krnm	213	6	data	data	NN
cord-022353-q2k2krnm	213	7	depends	depend	VBZ
cord-022353-q2k2krnm	213	8	on	on	IN
cord-022353-q2k2krnm	213	9	controlling	control	VBG
cord-022353-q2k2krnm	213	10	a	a	DT
cord-022353-q2k2krnm	213	11	large	large	JJ
cord-022353-q2k2krnm	213	12	number	number	NN
cord-022353-q2k2krnm	213	13	of	of	IN
cord-022353-q2k2krnm	213	14	variables	variable	NNS
cord-022353-q2k2krnm	213	15	known	know	VBN
cord-022353-q2k2krnm	213	16	to	to	TO
cord-022353-q2k2krnm	213	17	influence	influence	VB
cord-022353-q2k2krnm	213	18	chemistry	chemistry	NN
cord-022353-q2k2krnm	213	19	determinations	determination	NNS
cord-022353-q2k2krnm	213	20	.	.	.
cord-022353-q2k2krnm	214	1	Several	several	JJ
cord-022353-q2k2krnm	214	2	studies	study	NNS
cord-022353-q2k2krnm	214	3	have	have	VBP
cord-022353-q2k2krnm	214	4	demonstrated	demonstrate	VBN
cord-022353-q2k2krnm	214	5	significant	significant	JJ
cord-022353-q2k2krnm	214	6	differences	difference	NNS
cord-022353-q2k2krnm	214	7	in	in	IN
cord-022353-q2k2krnm	214	8	selected	select	VBN
cord-022353-q2k2krnm	214	9	serum	serum	NN
cord-022353-q2k2krnm	214	10	analyte	analyte	NN
cord-022353-q2k2krnm	214	11	concentrations	concentration	NNS
cord-022353-q2k2krnm	214	12	with	with	IN
cord-022353-q2k2krnm	214	13	age	age	NN
cord-022353-q2k2krnm	214	14	difference	difference	NN
cord-022353-q2k2krnm	214	15	in	in	IN
cord-022353-q2k2krnm	214	16	the	the	DT
cord-022353-q2k2krnm	214	17	same	same	JJ
cord-022353-q2k2krnm	214	18	strain	strain	NN
cord-022353-q2k2krnm	214	19	,	,	,
cord-022353-q2k2krnm	214	20	between	between	IN
cord-022353-q2k2krnm	214	21	sexes	sex	NNS
cord-022353-q2k2krnm	214	22	in	in	IN
cord-022353-q2k2krnm	214	23	the	the	DT
cord-022353-q2k2krnm	214	24	same	same	JJ
cord-022353-q2k2krnm	214	25	strain	strain	NN
cord-022353-q2k2krnm	214	26	,	,	,
cord-022353-q2k2krnm	214	27	and	and	CC
cord-022353-q2k2krnm	214	28	among	among	IN
cord-022353-q2k2krnm	214	29	strains	strain	NNS
cord-022353-q2k2krnm	214	30	(	(	-LRB-
cord-022353-q2k2krnm	214	31	Everett	Everett	NNP
cord-022353-q2k2krnm	214	32	and	and	CC
cord-022353-q2k2krnm	214	33	Harrison	Harrison	NNP
cord-022353-q2k2krnm	214	34	1983	1983	CD
cord-022353-q2k2krnm	214	35	)	)	-RRB-
cord-022353-q2k2krnm	214	36	.	.	.
cord-022353-q2k2krnm	215	1	carnosine	carnosine	NNP
cord-022353-q2k2krnm	215	2	or	or	CC
cord-022353-q2k2krnm	215	3	anserine	anserine	NN
cord-022353-q2k2krnm	215	4	.	.	.
cord-022353-q2k2krnm	216	1	Carnosine	Carnosine	NNP
cord-022353-q2k2krnm	216	2	serves	serve	VBZ
cord-022353-q2k2krnm	216	3	as	as	IN
cord-022353-q2k2krnm	216	4	a	a	DT
cord-022353-q2k2krnm	216	5	source	source	NN
cord-022353-q2k2krnm	216	6	of	of	IN
cord-022353-q2k2krnm	216	7	histidine	histidine	NN
cord-022353-q2k2krnm	216	8	when	when	WRB
cord-022353-q2k2krnm	216	9	histidine	histidine	NN
cord-022353-q2k2krnm	216	10	is	be	VBZ
cord-022353-q2k2krnm	216	11	restricted	restrict	VBN
cord-022353-q2k2krnm	216	12	.	.	.
cord-022353-q2k2krnm	217	1	Unlike	unlike	IN
cord-022353-q2k2krnm	217	2	other	other	JJ
cord-022353-q2k2krnm	217	3	mammals	mammal	NNS
cord-022353-q2k2krnm	217	4	,	,	,
cord-022353-q2k2krnm	217	5	mice	mouse	NNS
cord-022353-q2k2krnm	217	6	on	on	IN
cord-022353-q2k2krnm	217	7	histidine	histidine	NN
cord-022353-q2k2krnm	217	8	-	-	HYPH
cord-022353-q2k2krnm	217	9	free	free	JJ
cord-022353-q2k2krnm	217	10	diets	diet	NNS
cord-022353-q2k2krnm	217	11	show	show	VBP
cord-022353-q2k2krnm	217	12	signs	sign	NNS
cord-022353-q2k2krnm	217	13	of	of	IN
cord-022353-q2k2krnm	217	14	histidine	histidine	NN
cord-022353-q2k2krnm	217	15	deficiency	deficiency	NN
cord-022353-q2k2krnm	217	16	.	.	.
cord-022353-q2k2krnm	218	1	Fasting	fast	VBG
cord-022353-q2k2krnm	218	2	may	may	MD
cord-022353-q2k2krnm	218	3	also	also	RB
cord-022353-q2k2krnm	218	4	affect	affect	VB
cord-022353-q2k2krnm	218	5	the	the	DT
cord-022353-q2k2krnm	218	6	levels	level	NNS
cord-022353-q2k2krnm	218	7	of	of	IN
cord-022353-q2k2krnm	218	8	certain	certain	JJ
cord-022353-q2k2krnm	218	9	analytes	analyte	NNS
cord-022353-q2k2krnm	218	10	(	(	-LRB-
cord-022353-q2k2krnm	218	11	Quimby	Quimby	NNP
cord-022353-q2k2krnm	218	12	1999b	1999b	CD
cord-022353-q2k2krnm	218	13	)	)	-RRB-
cord-022353-q2k2krnm	218	14	.	.	.
cord-022353-q2k2krnm	219	1	The	the	DT
cord-022353-q2k2krnm	219	2	presence	presence	NN
cord-022353-q2k2krnm	219	3	or	or	CC
cord-022353-q2k2krnm	219	4	absence	absence	NN
cord-022353-q2k2krnm	219	5	(	(	-LRB-
cord-022353-q2k2krnm	219	6	axenic	axenic	NNP
cord-022353-q2k2krnm	219	7	mice	mouse	NNS
cord-022353-q2k2krnm	219	8	)	)	-RRB-
cord-022353-q2k2krnm	219	9	of	of	IN
cord-022353-q2k2krnm	219	10	intestinal	intestinal	JJ
cord-022353-q2k2krnm	219	11	microbial	microbial	JJ
cord-022353-q2k2krnm	219	12	flora	flora	NNS
cord-022353-q2k2krnm	219	13	is	be	VBZ
cord-022353-q2k2krnm	219	14	associated	associate	VBN
cord-022353-q2k2krnm	219	15	with	with	IN
cord-022353-q2k2krnm	219	16	dramatic	dramatic	JJ
cord-022353-q2k2krnm	219	17	changes	change	NNS
cord-022353-q2k2krnm	219	18	in	in	IN
cord-022353-q2k2krnm	219	19	immunoglobulin	immunoglobulin	NN
cord-022353-q2k2krnm	219	20	(	(	-LRB-
cord-022353-q2k2krnm	219	21	Ig	Ig	NNP
cord-022353-q2k2krnm	219	22	)	)	-RRB-
cord-022353-q2k2krnm	219	23	levels	level	NNS
cord-022353-q2k2krnm	219	24	and	and	CC
cord-022353-q2k2krnm	219	25	may	may	MD
cord-022353-q2k2krnm	219	26	be	be	VB
cord-022353-q2k2krnm	219	27	associated	associate	VBN
cord-022353-q2k2krnm	219	28	with	with	IN
cord-022353-q2k2krnm	219	29	changes	change	NNS
cord-022353-q2k2krnm	219	30	in	in	IN
cord-022353-q2k2krnm	219	31	other	other	JJ
cord-022353-q2k2krnm	219	32	analytes	analyte	NNS
cord-022353-q2k2krnm	219	33	as	as	RB
cord-022353-q2k2krnm	219	34	well	well	RB
cord-022353-q2k2krnm	219	35	.	.	.
cord-022353-q2k2krnm	220	1	For	for	IN
cord-022353-q2k2krnm	220	2	example	example	NN
cord-022353-q2k2krnm	220	3	,	,	,
cord-022353-q2k2krnm	220	4	axenic	axenic	JJ
cord-022353-q2k2krnm	220	5	mice	mouse	NNS
cord-022353-q2k2krnm	220	6	have	have	VBP
cord-022353-q2k2krnm	220	7	significantly	significantly	RB
cord-022353-q2k2krnm	220	8	lower	low	JJR
cord-022353-q2k2krnm	220	9	levels	level	NNS
cord-022353-q2k2krnm	220	10	of	of	IN
cord-022353-q2k2krnm	220	11	IgA	iga	NN
cord-022353-q2k2krnm	220	12	compared	compare	VBN
cord-022353-q2k2krnm	220	13	to	to	IN
cord-022353-q2k2krnm	220	14	conventional	conventional	JJ
cord-022353-q2k2krnm	220	15	mice	mouse	NNS
cord-022353-q2k2krnm	220	16	(	(	-LRB-
cord-022353-q2k2krnm	220	17	Moreau	Moreau	NNP
cord-022353-q2k2krnm	220	18	et	et	NNP
cord-022353-q2k2krnm	220	19	al	al	NNP
cord-022353-q2k2krnm	220	20	.	.	NNP
cord-022353-q2k2krnm	220	21	1982	1982	CD
cord-022353-q2k2krnm	220	22	)	)	-RRB-
cord-022353-q2k2krnm	220	23	.	.	.
cord-022353-q2k2krnm	221	1	The	the	DT
cord-022353-q2k2krnm	221	2	presence	presence	NN
cord-022353-q2k2krnm	221	3	of	of	IN
cord-022353-q2k2krnm	221	4	pathogens	pathogen	NNS
cord-022353-q2k2krnm	221	5	may	may	MD
cord-022353-q2k2krnm	221	6	be	be	VB
cord-022353-q2k2krnm	221	7	associated	associate	VBN
cord-022353-q2k2krnm	221	8	with	with	IN
cord-022353-q2k2krnm	221	9	dramatic	dramatic	JJ
cord-022353-q2k2krnm	221	10	changes	change	NNS
cord-022353-q2k2krnm	221	11	in	in	IN
cord-022353-q2k2krnm	221	12	various	various	JJ
cord-022353-q2k2krnm	221	13	analytes	analyte	NNS
cord-022353-q2k2krnm	221	14	,	,	,
cord-022353-q2k2krnm	221	15	even	even	RB
cord-022353-q2k2krnm	221	16	with	with	IN
cord-022353-q2k2krnm	221	17	subclinical	subclinical	JJ
cord-022353-q2k2krnm	221	18	infection	infection	NN
cord-022353-q2k2krnm	221	19	.	.	.
cord-022353-q2k2krnm	222	1	For	for	IN
cord-022353-q2k2krnm	222	2	instance	instance	NN
cord-022353-q2k2krnm	222	3	,	,	,
cord-022353-q2k2krnm	222	4	infection	infection	NN
cord-022353-q2k2krnm	222	5	with	with	IN
cord-022353-q2k2krnm	222	6	lactic	lactic	JJ
cord-022353-q2k2krnm	222	7	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	222	8	-	-	HYPH
cord-022353-q2k2krnm	222	9	elevating	elevate	VBG
cord-022353-q2k2krnm	222	10	virus	virus	NN
cord-022353-q2k2krnm	222	11	(	(	-LRB-
cord-022353-q2k2krnm	222	12	LDV	LDV	NNP
cord-022353-q2k2krnm	222	13	)	)	-RRB-
cord-022353-q2k2krnm	222	14	is	be	VBZ
cord-022353-q2k2krnm	222	15	associated	associate	VBN
cord-022353-q2k2krnm	222	16	with	with	IN
cord-022353-q2k2krnm	222	17	major	major	JJ
cord-022353-q2k2krnm	222	18	elevations	elevation	NNS
cord-022353-q2k2krnm	222	19	in	in	IN
cord-022353-q2k2krnm	222	20	serum	serum	NN
cord-022353-q2k2krnm	222	21	lactic	lactic	NN
cord-022353-q2k2krnm	222	22	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	222	23	,	,	,
cord-022353-q2k2krnm	222	24	isocitric	isocitric	JJ
cord-022353-q2k2krnm	222	25	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	222	26	,	,	,
cord-022353-q2k2krnm	222	27	malic	malic	JJ
cord-022353-q2k2krnm	222	28	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	222	29	,	,	,
cord-022353-q2k2krnm	222	30	aspartate	aspartate	NN
cord-022353-q2k2krnm	222	31	aminotransferase	aminotransferase	NN
cord-022353-q2k2krnm	222	32	,	,	,
cord-022353-q2k2krnm	222	33	and	and	CC
cord-022353-q2k2krnm	222	34	glutathione	glutathione	NN
cord-022353-q2k2krnm	222	35	reductase	reductase	NN
cord-022353-q2k2krnm	222	36	activities	activity	NNS
cord-022353-q2k2krnm	222	37	(	(	-LRB-
cord-022353-q2k2krnm	222	38	Quimby	Quimby	NNP
cord-022353-q2k2krnm	222	39	1999b	1999b	CD
cord-022353-q2k2krnm	222	40	)	)	-RRB-
cord-022353-q2k2krnm	222	41	.	.	.
cord-022353-q2k2krnm	223	1	aSummarized	aSummarized	NNP
cord-022353-q2k2krnm	223	2	from	from	IN
cord-022353-q2k2krnm	223	3	Loeb	Loeb	NNP
cord-022353-q2k2krnm	223	4	and	and	CC
cord-022353-q2k2krnm	223	5	Quimby	Quimby	NNP
cord-022353-q2k2krnm	223	6	(	(	-LRB-
cord-022353-q2k2krnm	223	7	1999	1999	CD
cord-022353-q2k2krnm	223	8	)	)	-RRB-
cord-022353-q2k2krnm	223	9	.	.	.
cord-022353-q2k2krnm	224	1	Alterations	alteration	NNS
cord-022353-q2k2krnm	224	2	in	in	IN
cord-022353-q2k2krnm	224	3	clinicopathologic	clinicopathologic	JJ
cord-022353-q2k2krnm	224	4	parameters	parameter	NNS
cord-022353-q2k2krnm	224	5	can	can	MD
cord-022353-q2k2krnm	224	6	be	be	VB
cord-022353-q2k2krnm	224	7	attributed	attribute	VBN
cord-022353-q2k2krnm	224	8	to	to	IN
cord-022353-q2k2krnm	224	9	stress	stress	NN
cord-022353-q2k2krnm	224	10	in	in	IN
cord-022353-q2k2krnm	224	11	mice	mouse	NNS
cord-022353-q2k2krnm	224	12	.	.	.
cord-022353-q2k2krnm	225	1	Landi	Landi	NNP
cord-022353-q2k2krnm	225	2	et	et	NNP
cord-022353-q2k2krnm	225	3	al	al	NNP
cord-022353-q2k2krnm	225	4	.	.	.
cord-022353-q2k2krnm	226	1	(	(	-LRB-
cord-022353-q2k2krnm	226	2	1982	1982	CD
cord-022353-q2k2krnm	226	3	)	)	-RRB-
cord-022353-q2k2krnm	226	4	found	find	VBD
cord-022353-q2k2krnm	226	5	that	that	IN
cord-022353-q2k2krnm	226	6	plasma	plasma	NN
cord-022353-q2k2krnm	226	7	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	226	8	concentrations	concentration	NNS
cord-022353-q2k2krnm	226	9	in	in	IN
cord-022353-q2k2krnm	226	10	mice	mouse	NNS
cord-022353-q2k2krnm	226	11	tested	test	VBN
cord-022353-q2k2krnm	226	12	within	within	IN
cord-022353-q2k2krnm	226	13	48	48	CD
cord-022353-q2k2krnm	226	14	h	h	NN
cord-022353-q2k2krnm	226	15	after	after	IN
cord-022353-q2k2krnm	226	16	arrival	arrival	NN
cord-022353-q2k2krnm	226	17	(	(	-LRB-
cord-022353-q2k2krnm	226	18	by	by	IN
cord-022353-q2k2krnm	226	19	plane	plane	NN
cord-022353-q2k2krnm	226	20	or	or	CC
cord-022353-q2k2krnm	226	21	truck	truck	NN
cord-022353-q2k2krnm	226	22	transport	transport	NN
cord-022353-q2k2krnm	226	23	)	)	-RRB-
cord-022353-q2k2krnm	226	24	were	be	VBD
cord-022353-q2k2krnm	226	25	significantly	significantly	RB
cord-022353-q2k2krnm	226	26	higher	high	JJR
cord-022353-q2k2krnm	226	27	than	than	IN
cord-022353-q2k2krnm	226	28	tested	test	VBN
cord-022353-q2k2krnm	226	29	after	after	IN
cord-022353-q2k2krnm	226	30	48	48	CD
cord-022353-q2k2krnm	226	31	h	h	NN
cord-022353-q2k2krnm	226	32	post	post	NN
cord-022353-q2k2krnm	226	33	arrival	arrival	NN
cord-022353-q2k2krnm	226	34	.	.	.
cord-022353-q2k2krnm	227	1	Mice	mouse	NNS
cord-022353-q2k2krnm	227	2	sensitized	sensitize	VBN
cord-022353-q2k2krnm	227	3	on	on	IN
cord-022353-q2k2krnm	227	4	arrival	arrival	NN
cord-022353-q2k2krnm	227	5	with	with	IN
cord-022353-q2k2krnm	227	6	sheep	sheep	NN
cord-022353-q2k2krnm	227	7	red	red	JJ
cord-022353-q2k2krnm	227	8	cells	cell	NNS
cord-022353-q2k2krnm	227	9	as	as	IN
cord-022353-q2k2krnm	227	10	an	an	DT
cord-022353-q2k2krnm	227	11	antigen	antigen	NN
cord-022353-q2k2krnm	227	12	had	have	VBD
cord-022353-q2k2krnm	227	13	significantly	significantly	RB
cord-022353-q2k2krnm	227	14	lower	low	JJR
cord-022353-q2k2krnm	227	15	antibody	antibody	NN
cord-022353-q2k2krnm	227	16	titers	titer	NNS
cord-022353-q2k2krnm	227	17	,	,	,
cord-022353-q2k2krnm	227	18	fewer	few	JJR
cord-022353-q2k2krnm	227	19	plaque	plaque	NN
cord-022353-q2k2krnm	227	20	-	-	HYPH
cord-022353-q2k2krnm	227	21	forming	form	VBG
cord-022353-q2k2krnm	227	22	cells	cell	NNS
cord-022353-q2k2krnm	227	23	,	,	,
cord-022353-q2k2krnm	227	24	and	and	CC
cord-022353-q2k2krnm	227	25	a	a	DT
cord-022353-q2k2krnm	227	26	decreased	decrease	VBN
cord-022353-q2k2krnm	227	27	delayed	delay	VBN
cord-022353-q2k2krnm	227	28	type	type	NN
cord-022353-q2k2krnm	227	29	of	of	IN
cord-022353-q2k2krnm	227	30	hypersensitivity	hypersensitivity	NN
cord-022353-q2k2krnm	227	31	reaction	reaction	NN
cord-022353-q2k2krnm	227	32	when	when	WRB
cord-022353-q2k2krnm	227	33	compared	compare	VBN
cord-022353-q2k2krnm	227	34	to	to	IN
cord-022353-q2k2krnm	227	35	normal	normal	JJ
cord-022353-q2k2krnm	227	36	mice	mouse	NNS
cord-022353-q2k2krnm	227	37	allowed	allow	VBN
cord-022353-q2k2krnm	227	38	to	to	TO
cord-022353-q2k2krnm	227	39	acclimate	acclimate	VB
cord-022353-q2k2krnm	227	40	to	to	IN
cord-022353-q2k2krnm	227	41	the	the	DT
cord-022353-q2k2krnm	227	42	facility	facility	NN
cord-022353-q2k2krnm	227	43	for	for	IN
cord-022353-q2k2krnm	227	44	48	48	CD
cord-022353-q2k2krnm	227	45	h	h	NN
cord-022353-q2k2krnm	227	46	before	before	IN
cord-022353-q2k2krnm	227	47	being	be	VBG
cord-022353-q2k2krnm	227	48	sensitized	sensitize	VBN
cord-022353-q2k2krnm	227	49	.	.	.
cord-022353-q2k2krnm	228	1	Elevated	elevated	JJ
cord-022353-q2k2krnm	228	2	serum	serum	NN
cord-022353-q2k2krnm	228	3	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	228	4	levels	level	NNS
cord-022353-q2k2krnm	228	5	can	can	MD
cord-022353-q2k2krnm	228	6	arise	arise	VB
cord-022353-q2k2krnm	228	7	from	from	IN
cord-022353-q2k2krnm	228	8	excessive	excessive	JJ
cord-022353-q2k2krnm	228	9	handling	handling	NN
cord-022353-q2k2krnm	228	10	of	of	IN
cord-022353-q2k2krnm	228	11	mice	mouse	NNS
cord-022353-q2k2krnm	228	12	prior	prior	RB
cord-022353-q2k2krnm	228	13	to	to	IN
cord-022353-q2k2krnm	228	14	blood	blood	NN
cord-022353-q2k2krnm	228	15	collection	collection	NN
cord-022353-q2k2krnm	228	16	.	.	.
cord-022353-q2k2krnm	229	1	The	the	DT
cord-022353-q2k2krnm	229	2	effect	effect	NN
cord-022353-q2k2krnm	229	3	of	of	IN
cord-022353-q2k2krnm	229	4	sample	sample	NN
cord-022353-q2k2krnm	229	5	storage	storage	NN
cord-022353-q2k2krnm	229	6	at	at	IN
cord-022353-q2k2krnm	229	7	various	various	JJ
cord-022353-q2k2krnm	229	8	temperatures	temperature	NNS
cord-022353-q2k2krnm	229	9	and	and	CC
cord-022353-q2k2krnm	229	10	for	for	IN
cord-022353-q2k2krnm	229	11	varying	vary	VBG
cord-022353-q2k2krnm	229	12	periods	period	NNS
cord-022353-q2k2krnm	229	13	has	have	VBZ
cord-022353-q2k2krnm	229	14	been	be	VBN
cord-022353-q2k2krnm	229	15	described	describe	VBN
cord-022353-q2k2krnm	229	16	.	.	.
cord-022353-q2k2krnm	230	1	Falk	Falk	NNP
cord-022353-q2k2krnm	230	2	et	et	NNP
cord-022353-q2k2krnm	230	3	al	al	NNP
cord-022353-q2k2krnm	230	4	.	.	.
cord-022353-q2k2krnm	231	1	(	(	-LRB-
cord-022353-q2k2krnm	231	2	1981	1981	CD
cord-022353-q2k2krnm	231	3	)	)	-RRB-
cord-022353-q2k2krnm	231	4	evaluated	evaluate	VBD
cord-022353-q2k2krnm	231	5	the	the	DT
cord-022353-q2k2krnm	231	6	effect	effect	NN
cord-022353-q2k2krnm	231	7	of	of	IN
cord-022353-q2k2krnm	231	8	storage	storage	NN
cord-022353-q2k2krnm	231	9	time	time	NN
cord-022353-q2k2krnm	231	10	(	(	-LRB-
cord-022353-q2k2krnm	231	11	after	after	IN
cord-022353-q2k2krnm	231	12	freezing	freeze	VBG
cord-022353-q2k2krnm	231	13	)	)	-RRB-
cord-022353-q2k2krnm	231	14	on	on	IN
cord-022353-q2k2krnm	231	15	20	20	CD
cord-022353-q2k2krnm	231	16	serum	serum	NN
cord-022353-q2k2krnm	231	17	analytes	analyte	NNS
cord-022353-q2k2krnm	231	18	in	in	IN
cord-022353-q2k2krnm	231	19	six	six	CD
cord-022353-q2k2krnm	231	20	laboratory	laboratory	NN
cord-022353-q2k2krnm	231	21	species	specie	NNS
cord-022353-q2k2krnm	231	22	.	.	.
cord-022353-q2k2krnm	232	1	They	-PRON-	PRP
cord-022353-q2k2krnm	232	2	found	find	VBD
cord-022353-q2k2krnm	232	3	that	that	IN
cord-022353-q2k2krnm	232	4	in	in	IN
cord-022353-q2k2krnm	232	5	the	the	DT
cord-022353-q2k2krnm	232	6	mouse	mouse	NN
cord-022353-q2k2krnm	232	7	,	,	,
cord-022353-q2k2krnm	232	8	only	only	RB
cord-022353-q2k2krnm	232	9	creatine	creatine	NN
cord-022353-q2k2krnm	232	10	kinase	kinase	NN
cord-022353-q2k2krnm	232	11	activity	activity	NN
cord-022353-q2k2krnm	232	12	changed	change	VBD
cord-022353-q2k2krnm	232	13	significantly	significantly	RB
cord-022353-q2k2krnm	232	14	with	with	IN
cord-022353-q2k2krnm	232	15	storage	storage	NN
cord-022353-q2k2krnm	232	16	up	up	IN
cord-022353-q2k2krnm	232	17	to	to	TO
cord-022353-q2k2krnm	232	18	28	28	CD
cord-022353-q2k2krnm	232	19	days	day	NNS
cord-022353-q2k2krnm	232	20	.	.	.
cord-022353-q2k2krnm	233	1	Hemolysis	Hemolysis	NNP
cord-022353-q2k2krnm	233	2	is	be	VBZ
cord-022353-q2k2krnm	233	3	a	a	DT
cord-022353-q2k2krnm	233	4	common	common	JJ
cord-022353-q2k2krnm	233	5	problem	problem	NN
cord-022353-q2k2krnm	233	6	during	during	IN
cord-022353-q2k2krnm	233	7	blood	blood	NN
cord-022353-q2k2krnm	233	8	collection	collection	NN
cord-022353-q2k2krnm	233	9	in	in	IN
cord-022353-q2k2krnm	233	10	mice	mouse	NNS
cord-022353-q2k2krnm	233	11	.	.	.
cord-022353-q2k2krnm	234	1	Hemolyzed	Hemolyzed	NNP
cord-022353-q2k2krnm	234	2	samples	sample	NNS
cord-022353-q2k2krnm	234	3	are	be	VBP
cord-022353-q2k2krnm	234	4	associated	associate	VBN
cord-022353-q2k2krnm	234	5	with	with	IN
cord-022353-q2k2krnm	234	6	changes	change	NNS
cord-022353-q2k2krnm	234	7	in	in	IN
cord-022353-q2k2krnm	234	8	various	various	JJ
cord-022353-q2k2krnm	234	9	enzymes	enzyme	NNS
cord-022353-q2k2krnm	234	10	,	,	,
cord-022353-q2k2krnm	234	11	such	such	JJ
cord-022353-q2k2krnm	234	12	as	as	IN
cord-022353-q2k2krnm	234	13	increased	increase	VBN
cord-022353-q2k2krnm	234	14	CK	CK	NNP
cord-022353-q2k2krnm	234	15	activity	activity	NN
cord-022353-q2k2krnm	234	16	and	and	CC
cord-022353-q2k2krnm	234	17	decreased	decrease	VBD
cord-022353-q2k2krnm	234	18	lipase	lipase	NN
cord-022353-q2k2krnm	234	19	activity	activity	NN
cord-022353-q2k2krnm	234	20	.	.	.
cord-022353-q2k2krnm	235	1	To	to	TO
cord-022353-q2k2krnm	235	2	minimize	minimize	VB
cord-022353-q2k2krnm	235	3	this	this	DT
cord-022353-q2k2krnm	235	4	,	,	,
cord-022353-q2k2krnm	235	5	Everett	Everett	NNP
cord-022353-q2k2krnm	235	6	and	and	CC
cord-022353-q2k2krnm	235	7	Harrison	Harrison	NNP
cord-022353-q2k2krnm	235	8	(	(	-LRB-
cord-022353-q2k2krnm	235	9	1983	1983	CD
cord-022353-q2k2krnm	235	10	)	)	-RRB-
cord-022353-q2k2krnm	235	11	recommend	recommend	VB
cord-022353-q2k2krnm	235	12	heparinized	heparinized	JJ
cord-022353-q2k2krnm	235	13	plasma	plasma	NN
cord-022353-q2k2krnm	235	14	and	and	CC
cord-022353-q2k2krnm	235	15	careful	careful	JJ
cord-022353-q2k2krnm	235	16	selection	selection	NN
cord-022353-q2k2krnm	235	17	of	of	IN
cord-022353-q2k2krnm	235	18	collection	collection	NN
cord-022353-q2k2krnm	235	19	sites	site	NNS
cord-022353-q2k2krnm	235	20	for	for	IN
cord-022353-q2k2krnm	235	21	routine	routine	JJ
cord-022353-q2k2krnm	235	22	chemical	chemical	NN
cord-022353-q2k2krnm	235	23	determinations	determination	NNS
cord-022353-q2k2krnm	235	24	.	.	.
cord-022353-q2k2krnm	236	1	The	the	DT
cord-022353-q2k2krnm	236	2	effect	effect	NN
cord-022353-q2k2krnm	236	3	of	of	IN
cord-022353-q2k2krnm	236	4	lipemia	lipemia	NN
cord-022353-q2k2krnm	236	5	,	,	,
cord-022353-q2k2krnm	236	6	various	various	JJ
cord-022353-q2k2krnm	236	7	anticoagulants	anticoagulant	NNS
cord-022353-q2k2krnm	236	8	,	,	,
cord-022353-q2k2krnm	236	9	and	and	CC
cord-022353-q2k2krnm	236	10	pharmacologic	pharmacologic	JJ
cord-022353-q2k2krnm	236	11	agents	agent	NNS
cord-022353-q2k2krnm	236	12	on	on	IN
cord-022353-q2k2krnm	236	13	clinical	clinical	JJ
cord-022353-q2k2krnm	236	14	chemistry	chemistry	NN
cord-022353-q2k2krnm	236	15	values	value	NNS
cord-022353-q2k2krnm	236	16	has	have	VBZ
cord-022353-q2k2krnm	236	17	been	be	VBN
cord-022353-q2k2krnm	236	18	reviewed	review	VBN
cord-022353-q2k2krnm	236	19	for	for	IN
cord-022353-q2k2krnm	236	20	domestic	domestic	JJ
cord-022353-q2k2krnm	236	21	animals	animal	NNS
cord-022353-q2k2krnm	236	22	(	(	-LRB-
cord-022353-q2k2krnm	236	23	Meyer	Meyer	NNP
cord-022353-q2k2krnm	236	24	and	and	CC
cord-022353-q2k2krnm	236	25	Harvey	Harvey	NNP
cord-022353-q2k2krnm	236	26	1998	1998	CD
cord-022353-q2k2krnm	236	27	)	)	-RRB-
cord-022353-q2k2krnm	236	28	.	.	.
cord-022353-q2k2krnm	237	1	using	use	VBG
cord-022353-q2k2krnm	237	2	several	several	JJ
cord-022353-q2k2krnm	237	3	methods	method	NNS
cord-022353-q2k2krnm	237	4	.	.	.
cord-022353-q2k2krnm	238	1	Regardless	regardless	RB
cord-022353-q2k2krnm	238	2	of	of	IN
cord-022353-q2k2krnm	238	3	the	the	DT
cord-022353-q2k2krnm	238	4	distribution	distribution	NN
cord-022353-q2k2krnm	238	5	of	of	IN
cord-022353-q2k2krnm	238	6	data	datum	NNS
cord-022353-q2k2krnm	238	7	,	,	,
cord-022353-q2k2krnm	238	8	it	-PRON-	PRP
cord-022353-q2k2krnm	238	9	is	be	VBZ
cord-022353-q2k2krnm	238	10	generally	generally	RB
cord-022353-q2k2krnm	238	11	useful	useful	JJ
cord-022353-q2k2krnm	238	12	to	to	TO
cord-022353-q2k2krnm	238	13	describe	describe	VB
cord-022353-q2k2krnm	238	14	the	the	DT
cord-022353-q2k2krnm	238	15	limits	limit	NNS
cord-022353-q2k2krnm	238	16	that	that	WDT
cord-022353-q2k2krnm	238	17	include	include	VBP
cord-022353-q2k2krnm	238	18	95	95	CD
cord-022353-q2k2krnm	238	19	%	%	NN
cord-022353-q2k2krnm	238	20	of	of	IN
cord-022353-q2k2krnm	238	21	the	the	DT
cord-022353-q2k2krnm	238	22	test	test	NN
cord-022353-q2k2krnm	238	23	results	result	NNS
cord-022353-q2k2krnm	238	24	in	in	IN
cord-022353-q2k2krnm	238	25	a	a	DT
cord-022353-q2k2krnm	238	26	disease	disease	NN
cord-022353-q2k2krnm	238	27	-	-	HYPH
cord-022353-q2k2krnm	238	28	free	free	JJ
cord-022353-q2k2krnm	238	29	population	population	NN
cord-022353-q2k2krnm	238	30	.	.	.
cord-022353-q2k2krnm	239	1	For	for	IN
cord-022353-q2k2krnm	239	2	values	value	NNS
cord-022353-q2k2krnm	239	3	exhibiting	exhibit	VBG
cord-022353-q2k2krnm	239	4	a	a	DT
cord-022353-q2k2krnm	239	5	Gaussian	gaussian	JJ
cord-022353-q2k2krnm	239	6	distribution	distribution	NN
cord-022353-q2k2krnm	239	7	,	,	,
cord-022353-q2k2krnm	239	8	parametric	parametric	JJ
cord-022353-q2k2krnm	239	9	methods	method	NNS
cord-022353-q2k2krnm	239	10	(	(	-LRB-
cord-022353-q2k2krnm	239	11	such	such	JJ
cord-022353-q2k2krnm	239	12	as	as	IN
cord-022353-q2k2krnm	239	13	mean	mean	JJ
cord-022353-q2k2krnm	239	14	and	and	CC
cord-022353-q2k2krnm	239	15	standard	standard	JJ
cord-022353-q2k2krnm	239	16	deviation	deviation	NN
cord-022353-q2k2krnm	239	17	)	)	-RRB-
cord-022353-q2k2krnm	239	18	are	be	VBP
cord-022353-q2k2krnm	239	19	appropriate	appropriate	JJ
cord-022353-q2k2krnm	239	20	.	.	.
cord-022353-q2k2krnm	240	1	For	for	IN
cord-022353-q2k2krnm	240	2	Gaussian	gaussian	JJ
cord-022353-q2k2krnm	240	3	distributed	distribute	VBN
cord-022353-q2k2krnm	240	4	data	datum	NNS
cord-022353-q2k2krnm	240	5	,	,	,
cord-022353-q2k2krnm	240	6	this	this	DT
cord-022353-q2k2krnm	240	7	is	be	VBZ
cord-022353-q2k2krnm	240	8	the	the	DT
cord-022353-q2k2krnm	240	9	range	range	NN
cord-022353-q2k2krnm	240	10	that	that	WDT
cord-022353-q2k2krnm	240	11	includes	include	VBZ
cord-022353-q2k2krnm	240	12	two	two	CD
cord-022353-q2k2krnm	240	13	standard	standard	JJ
cord-022353-q2k2krnm	240	14	deviations	deviation	NNS
cord-022353-q2k2krnm	240	15	above	above	IN
cord-022353-q2k2krnm	240	16	and	and	CC
cord-022353-q2k2krnm	240	17	below	below	IN
cord-022353-q2k2krnm	240	18	the	the	DT
cord-022353-q2k2krnm	240	19	mean	mean	NN
cord-022353-q2k2krnm	240	20	.	.	.
cord-022353-q2k2krnm	241	1	Certain	certain	JJ
cord-022353-q2k2krnm	241	2	murine	murine	JJ
cord-022353-q2k2krnm	241	3	analytes	analyte	NNS
cord-022353-q2k2krnm	241	4	have	have	VBP
cord-022353-q2k2krnm	241	5	non	non	JJ
cord-022353-q2k2krnm	241	6	-	-	JJ
cord-022353-q2k2krnm	241	7	Gaussian	gaussian	JJ
cord-022353-q2k2krnm	241	8	distributions	distribution	NNS
cord-022353-q2k2krnm	241	9	and	and	CC
cord-022353-q2k2krnm	241	10	must	must	MD
cord-022353-q2k2krnm	241	11	be	be	VB
cord-022353-q2k2krnm	241	12	evaluated	evaluate	VBN
cord-022353-q2k2krnm	241	13	using	use	VBG
cord-022353-q2k2krnm	241	14	nonparametric	nonparametric	JJ
cord-022353-q2k2krnm	241	15	methods	method	NNS
cord-022353-q2k2krnm	241	16	.	.	.
cord-022353-q2k2krnm	242	1	A	a	DT
cord-022353-q2k2krnm	242	2	variety	variety	NN
cord-022353-q2k2krnm	242	3	of	of	IN
cord-022353-q2k2krnm	242	4	methods	method	NNS
cord-022353-q2k2krnm	242	5	are	be	VBP
cord-022353-q2k2krnm	242	6	available	available	JJ
cord-022353-q2k2krnm	242	7	,	,	,
cord-022353-q2k2krnm	242	8	including	include	VBG
cord-022353-q2k2krnm	242	9	the	the	DT
cord-022353-q2k2krnm	242	10	percentile	percentile	JJ
cord-022353-q2k2krnm	242	11	method	method	NN
cord-022353-q2k2krnm	242	12	and	and	CC
cord-022353-q2k2krnm	242	13	logarithm	logarithm	NN
cord-022353-q2k2krnm	242	14	-	-	HYPH
cord-022353-q2k2krnm	242	15	transformed	transform	VBN
cord-022353-q2k2krnm	242	16	data	datum	NNS
cord-022353-q2k2krnm	242	17	analyzed	analyze	VBN
cord-022353-q2k2krnm	242	18	with	with	IN
cord-022353-q2k2krnm	242	19	parametric	parametric	JJ
cord-022353-q2k2krnm	242	20	methods	method	NNS
cord-022353-q2k2krnm	242	21	.	.	.
cord-022353-q2k2krnm	243	1	The	the	DT
cord-022353-q2k2krnm	243	2	method	method	NN
cord-022353-q2k2krnm	243	3	of	of	IN
cord-022353-q2k2krnm	243	4	percentile	percentile	JJ
cord-022353-q2k2krnm	243	5	estimates	estimate	NNS
cord-022353-q2k2krnm	243	6	is	be	VBZ
cord-022353-q2k2krnm	243	7	more	more	RBR
cord-022353-q2k2krnm	243	8	vulnerable	vulnerable	JJ
cord-022353-q2k2krnm	243	9	to	to	IN
cord-022353-q2k2krnm	243	10	bias	bias	NN
cord-022353-q2k2krnm	243	11	due	due	IN
cord-022353-q2k2krnm	243	12	to	to	IN
cord-022353-q2k2krnm	243	13	extreme	extreme	JJ
cord-022353-q2k2krnm	243	14	values	value	NNS
cord-022353-q2k2krnm	243	15	(	(	-LRB-
cord-022353-q2k2krnm	243	16	outliers	outlier	NNS
cord-022353-q2k2krnm	243	17	)	)	-RRB-
cord-022353-q2k2krnm	243	18	than	than	IN
cord-022353-q2k2krnm	243	19	is	be	VBZ
cord-022353-q2k2krnm	243	20	the	the	DT
cord-022353-q2k2krnm	243	21	log	log	NN
cord-022353-q2k2krnm	243	22	-	-	HYPH
cord-022353-q2k2krnm	243	23	transformed	transform	VBN
cord-022353-q2k2krnm	243	24	parametric	parametric	JJ
cord-022353-q2k2krnm	243	25	method	method	NN
cord-022353-q2k2krnm	243	26	.	.	.
cord-022353-q2k2krnm	244	1	Boyd	Boyd	NNP
cord-022353-q2k2krnm	244	2	(	(	-LRB-
cord-022353-q2k2krnm	244	3	1985	1985	CD
cord-022353-q2k2krnm	244	4	)	)	-RRB-
cord-022353-q2k2krnm	244	5	asserts	assert	VBZ
cord-022353-q2k2krnm	244	6	that	that	IN
cord-022353-q2k2krnm	244	7	a	a	DT
cord-022353-q2k2krnm	244	8	sample	sample	NN
cord-022353-q2k2krnm	244	9	size	size	NN
cord-022353-q2k2krnm	244	10	of	of	IN
cord-022353-q2k2krnm	244	11	at	at	RB
cord-022353-q2k2krnm	244	12	least	least	JJS
cord-022353-q2k2krnm	244	13	120	120	CD
cord-022353-q2k2krnm	244	14	is	be	VBZ
cord-022353-q2k2krnm	244	15	required	require	VBN
cord-022353-q2k2krnm	244	16	to	to	TO
cord-022353-q2k2krnm	244	17	give	give	VB
cord-022353-q2k2krnm	244	18	90	90	CD
cord-022353-q2k2krnm	244	19	%	%	NN
cord-022353-q2k2krnm	244	20	confidence	confidence	NN
cord-022353-q2k2krnm	244	21	intervals	interval	NNS
cord-022353-q2k2krnm	244	22	using	use	VBG
cord-022353-q2k2krnm	244	23	the	the	DT
cord-022353-q2k2krnm	244	24	percentile	percentile	JJ
cord-022353-q2k2krnm	244	25	method	method	NN
cord-022353-q2k2krnm	244	26	,	,	,
cord-022353-q2k2krnm	244	27	whereas	whereas	IN
cord-022353-q2k2krnm	244	28	a	a	DT
cord-022353-q2k2krnm	244	29	sample	sample	NN
cord-022353-q2k2krnm	244	30	size	size	NN
cord-022353-q2k2krnm	244	31	of	of	IN
cord-022353-q2k2krnm	244	32	50	50	CD
cord-022353-q2k2krnm	244	33	may	may	MD
cord-022353-q2k2krnm	244	34	give	give	VB
cord-022353-q2k2krnm	244	35	reliable	reliable	JJ
cord-022353-q2k2krnm	244	36	ranges	range	NNS
cord-022353-q2k2krnm	244	37	if	if	IN
cord-022353-q2k2krnm	244	38	parametric	parametric	JJ
cord-022353-q2k2krnm	244	39	analyses	analysis	NNS
cord-022353-q2k2krnm	244	40	are	be	VBP
cord-022353-q2k2krnm	244	41	used	use	VBN
cord-022353-q2k2krnm	244	42	.	.	.
cord-022353-q2k2krnm	245	1	Neither	neither	DT
cord-022353-q2k2krnm	245	2	statistical	statistical	JJ
cord-022353-q2k2krnm	245	3	method	method	NN
cord-022353-q2k2krnm	245	4	just	just	RB
cord-022353-q2k2krnm	245	5	described	describe	VBN
cord-022353-q2k2krnm	245	6	will	will	MD
cord-022353-q2k2krnm	245	7	replace	replace	VB
cord-022353-q2k2krnm	245	8	raw	raw	JJ
cord-022353-q2k2krnm	245	9	data	datum	NNS
cord-022353-q2k2krnm	245	10	in	in	IN
cord-022353-q2k2krnm	245	11	certain	certain	JJ
cord-022353-q2k2krnm	245	12	situations	situation	NNS
cord-022353-q2k2krnm	245	13	,	,	,
cord-022353-q2k2krnm	245	14	such	such	JJ
cord-022353-q2k2krnm	245	15	as	as	IN
cord-022353-q2k2krnm	245	16	when	when	WRB
cord-022353-q2k2krnm	245	17	assessing	assess	VBG
cord-022353-q2k2krnm	245	18	analytes	analyte	NNS
cord-022353-q2k2krnm	245	19	for	for	IN
cord-022353-q2k2krnm	245	20	immune	immune	JJ
cord-022353-q2k2krnm	245	21	function	function	NN
cord-022353-q2k2krnm	245	22	,	,	,
cord-022353-q2k2krnm	245	23	nor	nor	CC
cord-022353-q2k2krnm	245	24	when	when	WRB
cord-022353-q2k2krnm	245	25	using	use	VBG
cord-022353-q2k2krnm	245	26	data	datum	NNS
cord-022353-q2k2krnm	245	27	derived	derive	VBN
cord-022353-q2k2krnm	245	28	from	from	IN
cord-022353-q2k2krnm	245	29	wild	wild	JJ
cord-022353-q2k2krnm	245	30	-	-	HYPH
cord-022353-q2k2krnm	245	31	type	type	NN
cord-022353-q2k2krnm	245	32	mice	mouse	NNS
cord-022353-q2k2krnm	245	33	as	as	IN
cord-022353-q2k2krnm	245	34	comparison	comparison	JJ
cord-022353-q2k2krnm	245	35	baseline	baseline	JJ
cord-022353-q2k2krnm	245	36	data	datum	NNS
cord-022353-q2k2krnm	245	37	for	for	IN
cord-022353-q2k2krnm	245	38	transgenic	transgenic	JJ
cord-022353-q2k2krnm	245	39	and	and	CC
cord-022353-q2k2krnm	245	40	KO	KO	NNP
cord-022353-q2k2krnm	245	41	mice	mouse	NNS
cord-022353-q2k2krnm	245	42	.	.	.
cord-022353-q2k2krnm	246	1	The	the	DT
cord-022353-q2k2krnm	246	2	issue	issue	NN
cord-022353-q2k2krnm	246	3	of	of	IN
cord-022353-q2k2krnm	246	4	quality	quality	NN
cord-022353-q2k2krnm	246	5	control	control	NN
cord-022353-q2k2krnm	246	6	and	and	CC
cord-022353-q2k2krnm	246	7	test	test	NN
cord-022353-q2k2krnm	246	8	validity	validity	NN
cord-022353-q2k2krnm	246	9	has	have	VBZ
cord-022353-q2k2krnm	246	10	been	be	VBN
cord-022353-q2k2krnm	246	11	thoroughly	thoroughly	RB
cord-022353-q2k2krnm	246	12	discussed	discuss	VBN
cord-022353-q2k2krnm	246	13	for	for	IN
cord-022353-q2k2krnm	246	14	common	common	JJ
cord-022353-q2k2krnm	246	15	domestic	domestic	JJ
cord-022353-q2k2krnm	246	16	animals	animal	NNS
cord-022353-q2k2krnm	246	17	and	and	CC
cord-022353-q2k2krnm	246	18	is	be	VBZ
cord-022353-q2k2krnm	246	19	applicable	applicable	JJ
cord-022353-q2k2krnm	246	20	to	to	IN
cord-022353-q2k2krnm	246	21	chemistry	chemistry	NN
cord-022353-q2k2krnm	246	22	determinations	determination	NNS
cord-022353-q2k2krnm	246	23	in	in	IN
cord-022353-q2k2krnm	246	24	mice	mouse	NNS
cord-022353-q2k2krnm	246	25	(	(	-LRB-
cord-022353-q2k2krnm	246	26	Meyer	Meyer	NNP
cord-022353-q2k2krnm	246	27	and	and	CC
cord-022353-q2k2krnm	246	28	Harvey	Harvey	NNP
cord-022353-q2k2krnm	246	29	1998	1998	CD
cord-022353-q2k2krnm	246	30	)	)	-RRB-
cord-022353-q2k2krnm	246	31	.	.	.
cord-022353-q2k2krnm	247	1	Quality	quality	NN
cord-022353-q2k2krnm	247	2	assurance	assurance	NN
cord-022353-q2k2krnm	247	3	in	in	IN
cord-022353-q2k2krnm	247	4	clinical	clinical	JJ
cord-022353-q2k2krnm	247	5	chemistry	chemistry	NN
cord-022353-q2k2krnm	247	6	determinations	determination	NNS
cord-022353-q2k2krnm	247	7	is	be	VBZ
cord-022353-q2k2krnm	247	8	important	important	JJ
cord-022353-q2k2krnm	247	9	to	to	TO
cord-022353-q2k2krnm	247	10	ensure	ensure	VB
cord-022353-q2k2krnm	247	11	that	that	IN
cord-022353-q2k2krnm	247	12	consistently	consistently	RB
cord-022353-q2k2krnm	247	13	accurate	accurate	JJ
cord-022353-q2k2krnm	247	14	and	and	CC
cord-022353-q2k2krnm	247	15	precise	precise	JJ
cord-022353-q2k2krnm	247	16	results	result	NNS
cord-022353-q2k2krnm	247	17	are	be	VBP
cord-022353-q2k2krnm	247	18	achieved	achieve	VBN
cord-022353-q2k2krnm	247	19	.	.	.
cord-022353-q2k2krnm	248	1	Everett	Everett	NNP
cord-022353-q2k2krnm	248	2	and	and	CC
cord-022353-q2k2krnm	248	3	Harrison	Harrison	NNP
cord-022353-q2k2krnm	248	4	(	(	-LRB-
cord-022353-q2k2krnm	248	5	1983	1983	CD
cord-022353-q2k2krnm	248	6	)	)	-RRB-
cord-022353-q2k2krnm	248	7	stressed	stress	VBD
cord-022353-q2k2krnm	248	8	the	the	DT
cord-022353-q2k2krnm	248	9	importance	importance	NN
cord-022353-q2k2krnm	248	10	of	of	IN
cord-022353-q2k2krnm	248	11	a	a	DT
cord-022353-q2k2krnm	248	12	clinical	clinical	JJ
cord-022353-q2k2krnm	248	13	pathology	pathology	NN
cord-022353-q2k2krnm	248	14	quality	quality	NN
cord-022353-q2k2krnm	248	15	assurance	assurance	NN
cord-022353-q2k2krnm	248	16	program	program	NN
cord-022353-q2k2krnm	248	17	that	that	WDT
cord-022353-q2k2krnm	248	18	includes	include	VBZ
cord-022353-q2k2krnm	248	19	regular	regular	JJ
cord-022353-q2k2krnm	248	20	assays	assay	NNS
cord-022353-q2k2krnm	248	21	of	of	IN
cord-022353-q2k2krnm	248	22	pooled	pool	VBN
cord-022353-q2k2krnm	248	23	and	and	CC
cord-022353-q2k2krnm	248	24	commercially	commercially	RB
cord-022353-q2k2krnm	248	25	prepared	prepared	JJ
cord-022353-q2k2krnm	248	26	pre	pre	JJ
cord-022353-q2k2krnm	248	27	-	-	JJ
cord-022353-q2k2krnm	248	28	assayed	assay	VBN
cord-022353-q2k2krnm	248	29	sera	sera	NNP
cord-022353-q2k2krnm	248	30	.	.	.
cord-022353-q2k2krnm	249	1	In	in	IN
cord-022353-q2k2krnm	249	2	addition	addition	NN
cord-022353-q2k2krnm	249	3	,	,	,
cord-022353-q2k2krnm	249	4	they	-PRON-	PRP
cord-022353-q2k2krnm	249	5	encourage	encourage	VBP
cord-022353-q2k2krnm	249	6	participation	participation	NN
cord-022353-q2k2krnm	249	7	in	in	IN
cord-022353-q2k2krnm	249	8	a	a	DT
cord-022353-q2k2krnm	249	9	subscription	subscription	NN
cord-022353-q2k2krnm	249	10	quality	quality	NN
cord-022353-q2k2krnm	249	11	assurance	assurance	NN
cord-022353-q2k2krnm	249	12	program	program	NN
cord-022353-q2k2krnm	249	13	,	,	,
cord-022353-q2k2krnm	249	14	such	such	JJ
cord-022353-q2k2krnm	249	15	as	as	IN
cord-022353-q2k2krnm	249	16	with	with	IN
cord-022353-q2k2krnm	249	17	a	a	DT
cord-022353-q2k2krnm	249	18	veterinary	veterinary	JJ
cord-022353-q2k2krnm	249	19	laboratory	laboratory	NN
cord-022353-q2k2krnm	249	20	association	association	NN
cord-022353-q2k2krnm	249	21	.	.	.
cord-022353-q2k2krnm	250	1	The	the	DT
cord-022353-q2k2krnm	250	2	within	within	IN
cord-022353-q2k2krnm	250	3	-	-	HYPH
cord-022353-q2k2krnm	250	4	day	day	NN
cord-022353-q2k2krnm	250	5	and	and	CC
cord-022353-q2k2krnm	250	6	day	day	NN
cord-022353-q2k2krnm	250	7	-	-	HYPH
cord-022353-q2k2krnm	250	8	to	to	IN
cord-022353-q2k2krnm	250	9	-	-	HYPH
cord-022353-q2k2krnm	250	10	day	day	NN
cord-022353-q2k2krnm	250	11	coefficient	coefficient	NN
cord-022353-q2k2krnm	250	12	of	of	IN
cord-022353-q2k2krnm	250	13	variation	variation	NN
cord-022353-q2k2krnm	250	14	should	should	MD
cord-022353-q2k2krnm	250	15	be	be	VB
cord-022353-q2k2krnm	250	16	known	know	VBN
cord-022353-q2k2krnm	250	17	for	for	IN
cord-022353-q2k2krnm	250	18	each	each	DT
cord-022353-q2k2krnm	250	19	analyte	analyte	NN
cord-022353-q2k2krnm	250	20	measured	measure	VBN
cord-022353-q2k2krnm	250	21	.	.	.
cord-022353-q2k2krnm	251	1	Due	due	IN
cord-022353-q2k2krnm	251	2	to	to	IN
cord-022353-q2k2krnm	251	3	the	the	DT
cord-022353-q2k2krnm	251	4	tremendous	tremendous	JJ
cord-022353-q2k2krnm	251	5	number	number	NN
cord-022353-q2k2krnm	251	6	of	of	IN
cord-022353-q2k2krnm	251	7	variables	variable	NNS
cord-022353-q2k2krnm	251	8	known	know	VBN
cord-022353-q2k2krnm	251	9	to	to	TO
cord-022353-q2k2krnm	251	10	influence	influence	VB
cord-022353-q2k2krnm	251	11	clinical	clinical	JJ
cord-022353-q2k2krnm	251	12	chemistry	chemistry	NN
cord-022353-q2k2krnm	251	13	values	value	NNS
cord-022353-q2k2krnm	251	14	in	in	IN
cord-022353-q2k2krnm	251	15	mice	mouse	NNS
cord-022353-q2k2krnm	251	16	,	,	,
cord-022353-q2k2krnm	251	17	it	-PRON-	PRP
cord-022353-q2k2krnm	251	18	is	be	VBZ
cord-022353-q2k2krnm	251	19	often	often	RB
cord-022353-q2k2krnm	251	20	prudent	prudent	JJ
cord-022353-q2k2krnm	251	21	to	to	TO
cord-022353-q2k2krnm	251	22	test	test	VB
cord-022353-q2k2krnm	251	23	adequate	adequate	JJ
cord-022353-q2k2krnm	251	24	numbers	number	NNS
cord-022353-q2k2krnm	251	25	of	of	IN
cord-022353-q2k2krnm	251	26	control	control	NN
cord-022353-q2k2krnm	251	27	specimens	specimen	NNS
cord-022353-q2k2krnm	251	28	along	along	IN
cord-022353-q2k2krnm	251	29	with	with	IN
cord-022353-q2k2krnm	251	30	the	the	DT
cord-022353-q2k2krnm	251	31	experimental	experimental	JJ
cord-022353-q2k2krnm	251	32	samples	sample	NNS
cord-022353-q2k2krnm	251	33	.	.	.
cord-022353-q2k2krnm	252	1	This	this	DT
cord-022353-q2k2krnm	252	2	technique	technique	NN
cord-022353-q2k2krnm	252	3	is	be	VBZ
cord-022353-q2k2krnm	252	4	often	often	RB
cord-022353-q2k2krnm	252	5	impractical	impractical	JJ
cord-022353-q2k2krnm	252	6	when	when	WRB
cord-022353-q2k2krnm	252	7	tests	test	NNS
cord-022353-q2k2krnm	252	8	are	be	VBP
cord-022353-q2k2krnm	252	9	being	be	VBG
cord-022353-q2k2krnm	252	10	conducted	conduct	VBN
cord-022353-q2k2krnm	252	11	strictly	strictly	RB
cord-022353-q2k2krnm	252	12	for	for	IN
cord-022353-q2k2krnm	252	13	diagnostic	diagnostic	JJ
cord-022353-q2k2krnm	252	14	purposes	purpose	NNS
cord-022353-q2k2krnm	252	15	,	,	,
cord-022353-q2k2krnm	252	16	and	and	CC
cord-022353-q2k2krnm	252	17	in	in	IN
cord-022353-q2k2krnm	252	18	those	those	DT
cord-022353-q2k2krnm	252	19	situations	situation	NNS
cord-022353-q2k2krnm	252	20	,	,	,
cord-022353-q2k2krnm	252	21	compiled	compile	VBN
cord-022353-q2k2krnm	252	22	values	value	NNS
cord-022353-q2k2krnm	252	23	that	that	WDT
cord-022353-q2k2krnm	252	24	are	be	VBP
cord-022353-q2k2krnm	252	25	controlled	control	VBN
cord-022353-q2k2krnm	252	26	for	for	IN
cord-022353-q2k2krnm	252	27	as	as	RB
cord-022353-q2k2krnm	252	28	many	many	JJ
cord-022353-q2k2krnm	252	29	variables	variable	NNS
cord-022353-q2k2krnm	252	30	as	as	IN
cord-022353-q2k2krnm	252	31	possible	possible	JJ
cord-022353-q2k2krnm	252	32	may	may	MD
cord-022353-q2k2krnm	252	33	be	be	VB
cord-022353-q2k2krnm	252	34	sufficient	sufficient	JJ
cord-022353-q2k2krnm	252	35	.	.	.
cord-022353-q2k2krnm	253	1	The	the	DT
cord-022353-q2k2krnm	253	2	values	value	NNS
cord-022353-q2k2krnm	253	3	that	that	WDT
cord-022353-q2k2krnm	253	4	define	define	VBP
cord-022353-q2k2krnm	253	5	a	a	DT
cord-022353-q2k2krnm	253	6	reference	reference	NN
cord-022353-q2k2krnm	253	7	range	range	NN
cord-022353-q2k2krnm	253	8	for	for	IN
cord-022353-q2k2krnm	253	9	a	a	DT
cord-022353-q2k2krnm	253	10	particular	particular	JJ
cord-022353-q2k2krnm	253	11	analyte	analyte	NN
cord-022353-q2k2krnm	253	12	or	or	CC
cord-022353-q2k2krnm	253	13	biomarker	biomarker	NN
cord-022353-q2k2krnm	253	14	in	in	IN
cord-022353-q2k2krnm	253	15	normal	normal	JJ
cord-022353-q2k2krnm	253	16	or	or	CC
cord-022353-q2k2krnm	253	17	healthy	healthy	JJ
cord-022353-q2k2krnm	253	18	mice	mouse	NNS
cord-022353-q2k2krnm	253	19	may	may	MD
cord-022353-q2k2krnm	253	20	be	be	VB
cord-022353-q2k2krnm	253	21	described	describe	VBN
cord-022353-q2k2krnm	253	22	This	this	DT
cord-022353-q2k2krnm	253	23	section	section	NN
cord-022353-q2k2krnm	253	24	is	be	VBZ
cord-022353-q2k2krnm	253	25	intended	intend	VBN
cord-022353-q2k2krnm	253	26	to	to	TO
cord-022353-q2k2krnm	253	27	serve	serve	VB
cord-022353-q2k2krnm	253	28	as	as	IN
cord-022353-q2k2krnm	253	29	a	a	DT
cord-022353-q2k2krnm	253	30	review	review	NN
cord-022353-q2k2krnm	253	31	of	of	IN
cord-022353-q2k2krnm	253	32	specific	specific	JJ
cord-022353-q2k2krnm	253	33	tests	test	NNS
cord-022353-q2k2krnm	253	34	for	for	IN
cord-022353-q2k2krnm	253	35	routine	routine	JJ
cord-022353-q2k2krnm	253	36	analytes	analyte	NNS
cord-022353-q2k2krnm	253	37	.	.	.
cord-022353-q2k2krnm	254	1	Additionally	additionally	RB
cord-022353-q2k2krnm	254	2	,	,	,
cord-022353-q2k2krnm	254	3	a	a	DT
cord-022353-q2k2krnm	254	4	more	more	RBR
cord-022353-q2k2krnm	254	5	comprehensive	comprehensive	JJ
cord-022353-q2k2krnm	254	6	discussion	discussion	NN
cord-022353-q2k2krnm	254	7	is	be	VBZ
cord-022353-q2k2krnm	254	8	presented	present	VBN
cord-022353-q2k2krnm	254	9	for	for	IN
cord-022353-q2k2krnm	254	10	analytes	analyte	NNS
cord-022353-q2k2krnm	254	11	and	and	CC
cord-022353-q2k2krnm	254	12	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	254	13	involved	involve	VBN
cord-022353-q2k2krnm	254	14	in	in	IN
cord-022353-q2k2krnm	254	15	two	two	CD
cord-022353-q2k2krnm	254	16	areas	area	NNS
cord-022353-q2k2krnm	254	17	of	of	IN
cord-022353-q2k2krnm	254	18	translational	translational	JJ
cord-022353-q2k2krnm	254	19	research	research	NN
cord-022353-q2k2krnm	254	20	of	of	IN
cord-022353-q2k2krnm	254	21	intense	intense	JJ
cord-022353-q2k2krnm	254	22	interest	interest	NN
cord-022353-q2k2krnm	254	23	(	(	-LRB-
cord-022353-q2k2krnm	254	24	obesity	obesity	NN
cord-022353-q2k2krnm	254	25	/	/	SYM
cord-022353-q2k2krnm	254	26	diabetes	diabetes	NN
cord-022353-q2k2krnm	254	27	and	and	CC
cord-022353-q2k2krnm	254	28	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	254	29	)	)	-RRB-
cord-022353-q2k2krnm	254	30	and	and	CC
cord-022353-q2k2krnm	254	31	novel	novel	JJ
cord-022353-q2k2krnm	254	32	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	254	33	of	of	IN
cord-022353-q2k2krnm	254	34	disease	disease	NN
cord-022353-q2k2krnm	254	35	(	(	-LRB-
cord-022353-q2k2krnm	254	36	such	such	JJ
cord-022353-q2k2krnm	254	37	as	as	IN
cord-022353-q2k2krnm	254	38	immune	immune	JJ
cord-022353-q2k2krnm	254	39	function	function	NN
cord-022353-q2k2krnm	254	40	tests	test	NNS
cord-022353-q2k2krnm	254	41	)	)	-RRB-
cord-022353-q2k2krnm	254	42	.	.	.
cord-022353-q2k2krnm	255	1	Only	only	RB
cord-022353-q2k2krnm	255	2	analytes	analyte	NNS
cord-022353-q2k2krnm	255	3	and	and	CC
cord-022353-q2k2krnm	255	4	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	255	5	for	for	IN
cord-022353-q2k2krnm	255	6	which	which	WDT
cord-022353-q2k2krnm	255	7	there	there	EX
cord-022353-q2k2krnm	255	8	are	be	VBP
cord-022353-q2k2krnm	255	9	currently	currently	RB
cord-022353-q2k2krnm	255	10	available	available	JJ
cord-022353-q2k2krnm	255	11	commercial	commercial	JJ
cord-022353-q2k2krnm	255	12	tests	test	NNS
cord-022353-q2k2krnm	255	13	for	for	IN
cord-022353-q2k2krnm	255	14	mice	mice	NN
cord-022353-q2k2krnm	255	15	serum	serum	NN
cord-022353-q2k2krnm	255	16	,	,	,
cord-022353-q2k2krnm	255	17	plasma	plasma	NN
cord-022353-q2k2krnm	255	18	,	,	,
cord-022353-q2k2krnm	255	19	and/or	and/or	CC
cord-022353-q2k2krnm	255	20	urine	urine	NN
cord-022353-q2k2krnm	255	21	are	be	VBP
cord-022353-q2k2krnm	255	22	discussed	discuss	VBN
cord-022353-q2k2krnm	255	23	;	;	:
cord-022353-q2k2krnm	255	24	certain	certain	JJ
cord-022353-q2k2krnm	255	25	analytes	analyte	NNS
cord-022353-q2k2krnm	255	26	and	and	CC
cord-022353-q2k2krnm	255	27	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	255	28	for	for	IN
cord-022353-q2k2krnm	255	29	which	which	WDT
cord-022353-q2k2krnm	255	30	commercially	commercially	RB
cord-022353-q2k2krnm	255	31	available	available	JJ
cord-022353-q2k2krnm	255	32	tests	test	NNS
cord-022353-q2k2krnm	255	33	are	be	VBP
cord-022353-q2k2krnm	255	34	not	not	RB
cord-022353-q2k2krnm	255	35	available	available	JJ
cord-022353-q2k2krnm	255	36	for	for	IN
cord-022353-q2k2krnm	255	37	the	the	DT
cord-022353-q2k2krnm	255	38	mouse	mouse	NN
cord-022353-q2k2krnm	255	39	(	(	-LRB-
cord-022353-q2k2krnm	255	40	such	such	JJ
cord-022353-q2k2krnm	255	41	as	as	IN
cord-022353-q2k2krnm	255	42	calcitonin	calcitonin	NN
cord-022353-q2k2krnm	255	43	)	)	-RRB-
cord-022353-q2k2krnm	255	44	are	be	VBP
cord-022353-q2k2krnm	255	45	not	not	RB
cord-022353-q2k2krnm	255	46	covered	cover	VBN
cord-022353-q2k2krnm	255	47	.	.	.
cord-022353-q2k2krnm	256	1	For	for	IN
cord-022353-q2k2krnm	256	2	more	more	RBR
cord-022353-q2k2krnm	256	3	complete	complete	JJ
cord-022353-q2k2krnm	256	4	information	information	NN
cord-022353-q2k2krnm	256	5	for	for	IN
cord-022353-q2k2krnm	256	6	the	the	DT
cord-022353-q2k2krnm	256	7	routine	routine	JJ
cord-022353-q2k2krnm	256	8	analytes	analyte	NNS
cord-022353-q2k2krnm	256	9	,	,	,
cord-022353-q2k2krnm	256	10	please	please	UH
cord-022353-q2k2krnm	256	11	refer	refer	VB
cord-022353-q2k2krnm	256	12	to	to	IN
cord-022353-q2k2krnm	256	13	Loeb	Loeb	NNP
cord-022353-q2k2krnm	256	14	and	and	CC
cord-022353-q2k2krnm	256	15	Quimby	Quimby	NNP
cord-022353-q2k2krnm	256	16	(	(	-LRB-
cord-022353-q2k2krnm	256	17	1999	1999	CD
cord-022353-q2k2krnm	256	18	)	)	-RRB-
cord-022353-q2k2krnm	256	19	.	.	.
cord-022353-q2k2krnm	257	1	Glucose	glucose	NN
cord-022353-q2k2krnm	257	2	is	be	VBZ
cord-022353-q2k2krnm	257	3	the	the	DT
cord-022353-q2k2krnm	257	4	main	main	JJ
cord-022353-q2k2krnm	257	5	source	source	NN
cord-022353-q2k2krnm	257	6	of	of	IN
cord-022353-q2k2krnm	257	7	energy	energy	NN
cord-022353-q2k2krnm	257	8	in	in	IN
cord-022353-q2k2krnm	257	9	mice	mouse	NNS
cord-022353-q2k2krnm	257	10	.	.	.
cord-022353-q2k2krnm	258	1	Blood	blood	NN
cord-022353-q2k2krnm	258	2	glucose	glucose	NN
cord-022353-q2k2krnm	258	3	concentrations	concentration	NNS
cord-022353-q2k2krnm	258	4	depend	depend	VBP
cord-022353-q2k2krnm	258	5	on	on	IN
cord-022353-q2k2krnm	258	6	the	the	DT
cord-022353-q2k2krnm	258	7	rates	rate	NNS
cord-022353-q2k2krnm	258	8	of	of	IN
cord-022353-q2k2krnm	258	9	entry	entry	NN
cord-022353-q2k2krnm	258	10	and	and	CC
cord-022353-q2k2krnm	258	11	the	the	DT
cord-022353-q2k2krnm	258	12	removal	removal	NN
cord-022353-q2k2krnm	258	13	rate	rate	NN
cord-022353-q2k2krnm	258	14	from	from	IN
cord-022353-q2k2krnm	258	15	the	the	DT
cord-022353-q2k2krnm	258	16	blood	blood	NN
cord-022353-q2k2krnm	258	17	.	.	.
cord-022353-q2k2krnm	259	1	The	the	DT
cord-022353-q2k2krnm	259	2	rate	rate	NN
cord-022353-q2k2krnm	259	3	of	of	IN
cord-022353-q2k2krnm	259	4	entry	entry	NN
cord-022353-q2k2krnm	259	5	is	be	VBZ
cord-022353-q2k2krnm	259	6	dependent	dependent	JJ
cord-022353-q2k2krnm	259	7	on	on	IN
cord-022353-q2k2krnm	259	8	intestinal	intestinal	JJ
cord-022353-q2k2krnm	259	9	absorption	absorption	NN
cord-022353-q2k2krnm	259	10	of	of	IN
cord-022353-q2k2krnm	259	11	dietary	dietary	JJ
cord-022353-q2k2krnm	259	12	sources	source	NNS
cord-022353-q2k2krnm	259	13	of	of	IN
cord-022353-q2k2krnm	259	14	glucose	glucose	NN
cord-022353-q2k2krnm	259	15	,	,	,
cord-022353-q2k2krnm	259	16	the	the	DT
cord-022353-q2k2krnm	259	17	breakdown	breakdown	NN
cord-022353-q2k2krnm	259	18	of	of	IN
cord-022353-q2k2krnm	259	19	body	body	NN
cord-022353-q2k2krnm	259	20	glycogen	glycogen	NN
cord-022353-q2k2krnm	259	21	stores	store	NNS
cord-022353-q2k2krnm	259	22	(	(	-LRB-
cord-022353-q2k2krnm	259	23	glycogenolysis	glycogenolysis	NNP
cord-022353-q2k2krnm	259	24	)	)	-RRB-
cord-022353-q2k2krnm	259	25	,	,	,
cord-022353-q2k2krnm	259	26	and	and	CC
cord-022353-q2k2krnm	259	27	synthesis	synthesis	NN
cord-022353-q2k2krnm	259	28	from	from	IN
cord-022353-q2k2krnm	259	29	gluconeogenic	gluconeogenic	JJ
cord-022353-q2k2krnm	259	30	metabolites	metabolite	NNS
cord-022353-q2k2krnm	259	31	(	(	-LRB-
cord-022353-q2k2krnm	259	32	gluconeogenesis	gluconeogenesis	NN
cord-022353-q2k2krnm	259	33	)	)	-RRB-
cord-022353-q2k2krnm	259	34	.	.	.
cord-022353-q2k2krnm	260	1	The	the	DT
cord-022353-q2k2krnm	260	2	removal	removal	NN
cord-022353-q2k2krnm	260	3	rate	rate	NN
cord-022353-q2k2krnm	260	4	is	be	VBZ
cord-022353-q2k2krnm	260	5	mainly	mainly	RB
cord-022353-q2k2krnm	260	6	dependent	dependent	JJ
cord-022353-q2k2krnm	260	7	on	on	IN
cord-022353-q2k2krnm	260	8	insulin	insulin	NN
cord-022353-q2k2krnm	260	9	,	,	,
cord-022353-q2k2krnm	260	10	which	which	WDT
cord-022353-q2k2krnm	260	11	is	be	VBZ
cord-022353-q2k2krnm	260	12	released	release	VBN
cord-022353-q2k2krnm	260	13	from	from	IN
cord-022353-q2k2krnm	260	14	[	[	-LRB-
cord-022353-q2k2krnm	260	15	3-cells	3-cells	CD
cord-022353-q2k2krnm	260	16	of	of	IN
cord-022353-q2k2krnm	260	17	the	the	DT
cord-022353-q2k2krnm	260	18	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	260	19	islets	islet	NNS
cord-022353-q2k2krnm	260	20	.	.	.
cord-022353-q2k2krnm	261	1	Insulin	insulin	NN
cord-022353-q2k2krnm	261	2	promotes	promote	VBZ
cord-022353-q2k2krnm	261	3	cellular	cellular	JJ
cord-022353-q2k2krnm	261	4	uptake	uptake	NN
cord-022353-q2k2krnm	261	5	of	of	IN
cord-022353-q2k2krnm	261	6	blood	blood	NN
cord-022353-q2k2krnm	261	7	glucose	glucose	NN
cord-022353-q2k2krnm	261	8	(	(	-LRB-
cord-022353-q2k2krnm	261	9	mainly	mainly	RB
cord-022353-q2k2krnm	261	10	in	in	IN
cord-022353-q2k2krnm	261	11	muscle	muscle	NN
cord-022353-q2k2krnm	261	12	,	,	,
cord-022353-q2k2krnm	261	13	liver	liver	NN
cord-022353-q2k2krnm	261	14	,	,	,
cord-022353-q2k2krnm	261	15	and	and	CC
cord-022353-q2k2krnm	261	16	fat	fat	NN
cord-022353-q2k2krnm	261	17	)	)	-RRB-
cord-022353-q2k2krnm	261	18	by	by	IN
cord-022353-q2k2krnm	261	19	stimulating	stimulate	VBG
cord-022353-q2k2krnm	261	20	the	the	DT
cord-022353-q2k2krnm	261	21	translocation	translocation	NN
cord-022353-q2k2krnm	261	22	of	of	IN
cord-022353-q2k2krnm	261	23	glucose	glucose	NN
cord-022353-q2k2krnm	261	24	transporters	transporter	NNS
cord-022353-q2k2krnm	261	25	,	,	,
cord-022353-q2k2krnm	261	26	GLUT-1	GLUT-1	VBN
cord-022353-q2k2krnm	261	27	to	to	IN
cord-022353-q2k2krnm	261	28	GLUT-7	GLUT-7	NNP
cord-022353-q2k2krnm	261	29	to	to	IN
cord-022353-q2k2krnm	261	30	the	the	DT
cord-022353-q2k2krnm	261	31	cell	cell	NN
cord-022353-q2k2krnm	261	32	membrane	membrane	NN
cord-022353-q2k2krnm	261	33	.	.	.
cord-022353-q2k2krnm	262	1	When	when	WRB
cord-022353-q2k2krnm	262	2	removed	remove	VBN
cord-022353-q2k2krnm	262	3	from	from	IN
cord-022353-q2k2krnm	262	4	circulation	circulation	NN
cord-022353-q2k2krnm	262	5	,	,	,
cord-022353-q2k2krnm	262	6	blood	blood	NN
cord-022353-q2k2krnm	262	7	glucose	glucose	NN
cord-022353-q2k2krnm	262	8	may	may	MD
cord-022353-q2k2krnm	262	9	either	either	CC
cord-022353-q2k2krnm	262	10	be	be	VB
cord-022353-q2k2krnm	262	11	utilized	utilize	VBN
cord-022353-q2k2krnm	262	12	(	(	-LRB-
cord-022353-q2k2krnm	262	13	to	to	TO
cord-022353-q2k2krnm	262	14	maintain	maintain	VB
cord-022353-q2k2krnm	262	15	cell	cell	NN
cord-022353-q2k2krnm	262	16	function	function	NN
cord-022353-q2k2krnm	262	17	)	)	-RRB-
cord-022353-q2k2krnm	262	18	or	or	CC
cord-022353-q2k2krnm	262	19	converted	convert	VBN
cord-022353-q2k2krnm	262	20	to	to	IN
cord-022353-q2k2krnm	262	21	fat	fat	NN
cord-022353-q2k2krnm	262	22	and	and	CC
cord-022353-q2k2krnm	262	23	glycogen	glycogen	NN
cord-022353-q2k2krnm	262	24	in	in	IN
cord-022353-q2k2krnm	262	25	liver	liver	NN
cord-022353-q2k2krnm	262	26	and	and	CC
cord-022353-q2k2krnm	262	27	muscle	muscle	NN
cord-022353-q2k2krnm	262	28	as	as	IN
cord-022353-q2k2krnm	262	29	an	an	DT
cord-022353-q2k2krnm	262	30	energy	energy	NN
cord-022353-q2k2krnm	262	31	store	store	NN
cord-022353-q2k2krnm	262	32	.	.	.
cord-022353-q2k2krnm	263	1	However	however	RB
cord-022353-q2k2krnm	263	2	,	,	,
cord-022353-q2k2krnm	263	3	the	the	DT
cord-022353-q2k2krnm	263	4	effect	effect	NN
cord-022353-q2k2krnm	263	5	of	of	IN
cord-022353-q2k2krnm	263	6	insulin	insulin	NN
cord-022353-q2k2krnm	263	7	is	be	VBZ
cord-022353-q2k2krnm	263	8	modulated	modulate	VBN
cord-022353-q2k2krnm	263	9	by	by	IN
cord-022353-q2k2krnm	263	10	other	other	JJ
cord-022353-q2k2krnm	263	11	hormones	hormone	NNS
cord-022353-q2k2krnm	263	12	(	(	-LRB-
cord-022353-q2k2krnm	263	13	such	such	JJ
cord-022353-q2k2krnm	263	14	as	as	IN
cord-022353-q2k2krnm	263	15	glucagon	glucagon	NN
cord-022353-q2k2krnm	263	16	,	,	,
cord-022353-q2k2krnm	263	17	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	263	18	,	,	,
cord-022353-q2k2krnm	263	19	GH	GH	NNP
cord-022353-q2k2krnm	263	20	,	,	,
cord-022353-q2k2krnm	263	21	epinephrine	epinephrine	NN
cord-022353-q2k2krnm	263	22	,	,	,
cord-022353-q2k2krnm	263	23	somatostatin	somatostatin	NN
cord-022353-q2k2krnm	263	24	,	,	,
cord-022353-q2k2krnm	263	25	and	and	CC
cord-022353-q2k2krnm	263	26	amylin	amylin	NN
cord-022353-q2k2krnm	263	27	)	)	-RRB-
cord-022353-q2k2krnm	263	28	that	that	WDT
cord-022353-q2k2krnm	263	29	ultimately	ultimately	RB
cord-022353-q2k2krnm	263	30	result	result	VBP
cord-022353-q2k2krnm	263	31	in	in	IN
cord-022353-q2k2krnm	263	32	the	the	DT
cord-022353-q2k2krnm	263	33	tight	tight	JJ
cord-022353-q2k2krnm	263	34	control	control	NN
cord-022353-q2k2krnm	263	35	the	the	DT
cord-022353-q2k2krnm	263	36	levels	level	NNS
cord-022353-q2k2krnm	263	37	of	of	IN
cord-022353-q2k2krnm	263	38	blood	blood	NN
cord-022353-q2k2krnm	263	39	glucose	glucose	NN
cord-022353-q2k2krnm	263	40	,	,	,
cord-022353-q2k2krnm	263	41	depending	depend	VBG
cord-022353-q2k2krnm	263	42	on	on	IN
cord-022353-q2k2krnm	263	43	tissue	tissue	NN
cord-022353-q2k2krnm	263	44	demands	demand	NNS
cord-022353-q2k2krnm	263	45	for	for	IN
cord-022353-q2k2krnm	263	46	energy	energy	NN
cord-022353-q2k2krnm	263	47	.	.	.
cord-022353-q2k2krnm	264	1	Glucagon	Glucagon	NNP
cord-022353-q2k2krnm	264	2	is	be	VBZ
cord-022353-q2k2krnm	264	3	released	release	VBN
cord-022353-q2k2krnm	264	4	from	from	IN
cord-022353-q2k2krnm	264	5	t~-cells	t~-cell	NNS
cord-022353-q2k2krnm	264	6	of	of	IN
cord-022353-q2k2krnm	264	7	the	the	DT
cord-022353-q2k2krnm	264	8	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	264	9	islets	islet	NNS
cord-022353-q2k2krnm	264	10	in	in	IN
cord-022353-q2k2krnm	264	11	response	response	NN
cord-022353-q2k2krnm	264	12	to	to	IN
cord-022353-q2k2krnm	264	13	low	low	JJ
cord-022353-q2k2krnm	264	14	circulating	circulate	VBG
cord-022353-q2k2krnm	264	15	glucose	glucose	NN
cord-022353-q2k2krnm	264	16	,	,	,
cord-022353-q2k2krnm	264	17	stimulating	stimulate	VBG
cord-022353-q2k2krnm	264	18	the	the	DT
cord-022353-q2k2krnm	264	19	liver	liver	NN
cord-022353-q2k2krnm	264	20	to	to	TO
cord-022353-q2k2krnm	264	21	increase	increase	VB
cord-022353-q2k2krnm	264	22	circulating	circulate	VBG
cord-022353-q2k2krnm	264	23	glucose	glucose	NN
cord-022353-q2k2krnm	264	24	through	through	IN
cord-022353-q2k2krnm	264	25	glycogenolysis	glycogenolysis	NN
cord-022353-q2k2krnm	264	26	and	and	CC
cord-022353-q2k2krnm	264	27	gluconeogenesis	gluconeogenesis	NN
cord-022353-q2k2krnm	264	28	.	.	.
cord-022353-q2k2krnm	265	1	Corticosterone	Corticosterone	NNP
cord-022353-q2k2krnm	265	2	and	and	CC
cord-022353-q2k2krnm	265	3	GH	GH	NNP
cord-022353-q2k2krnm	265	4	antagonize	antagonize	VBP
cord-022353-q2k2krnm	265	5	the	the	DT
cord-022353-q2k2krnm	265	6	action	action	NN
cord-022353-q2k2krnm	265	7	of	of	IN
cord-022353-q2k2krnm	265	8	insulin	insulin	NN
cord-022353-q2k2krnm	265	9	.	.	.
cord-022353-q2k2krnm	266	1	Epinephrine	epinephrine	NN
cord-022353-q2k2krnm	266	2	suppresses	suppress	VBZ
cord-022353-q2k2krnm	266	3	insulin	insulin	NN
cord-022353-q2k2krnm	266	4	release	release	NN
cord-022353-q2k2krnm	266	5	and	and	CC
cord-022353-q2k2krnm	266	6	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	266	7	glucagon	glucagon	NN
cord-022353-q2k2krnm	266	8	release	release	NN
cord-022353-q2k2krnm	266	9	and	and	CC
cord-022353-q2k2krnm	266	10	glycogenolysis	glycogenolysis	NN
cord-022353-q2k2krnm	266	11	.	.	.
cord-022353-q2k2krnm	267	1	Somatostatin	somatostatin	NN
cord-022353-q2k2krnm	267	2	suppresses	suppress	VBZ
cord-022353-q2k2krnm	267	3	both	both	CC
cord-022353-q2k2krnm	267	4	insulin	insulin	NN
cord-022353-q2k2krnm	267	5	and	and	CC
cord-022353-q2k2krnm	267	6	glucagon	glucagon	NN
cord-022353-q2k2krnm	267	7	secretion	secretion	NN
cord-022353-q2k2krnm	267	8	,	,	,
cord-022353-q2k2krnm	267	9	whereas	whereas	IN
cord-022353-q2k2krnm	267	10	amylin	amylin	NN
cord-022353-q2k2krnm	267	11	increases	increase	VBZ
cord-022353-q2k2krnm	267	12	blood	blood	NN
cord-022353-q2k2krnm	267	13	glucose	glucose	NN
cord-022353-q2k2krnm	267	14	,	,	,
cord-022353-q2k2krnm	267	15	blood	blood	NN
cord-022353-q2k2krnm	267	16	insulin	insulin	NN
cord-022353-q2k2krnm	267	17	,	,	,
cord-022353-q2k2krnm	267	18	and	and	CC
cord-022353-q2k2krnm	267	19	insulin	insulin	NN
cord-022353-q2k2krnm	267	20	resistance	resistance	NN
cord-022353-q2k2krnm	267	21	(	(	-LRB-
cord-022353-q2k2krnm	267	22	Burtis	Burtis	NNP
cord-022353-q2k2krnm	267	23	and	and	CC
cord-022353-q2k2krnm	267	24	Ashwood	Ashwood	NNP
cord-022353-q2k2krnm	267	25	2001	2001	CD
cord-022353-q2k2krnm	267	26	;	;	:
cord-022353-q2k2krnm	267	27	Kaneko	Kaneko	NNP
cord-022353-q2k2krnm	267	28	1999	1999	CD
cord-022353-q2k2krnm	267	29	)	)	-RRB-
cord-022353-q2k2krnm	267	30	.	.	.
cord-022353-q2k2krnm	268	1	Glucose	glucose	NN
cord-022353-q2k2krnm	268	2	determinations	determination	NNS
cord-022353-q2k2krnm	268	3	are	be	VBP
cord-022353-q2k2krnm	268	4	generally	generally	RB
cord-022353-q2k2krnm	268	5	conducted	conduct	VBN
cord-022353-q2k2krnm	268	6	on	on	IN
cord-022353-q2k2krnm	268	7	fresh	fresh	JJ
cord-022353-q2k2krnm	268	8	serum	serum	NN
cord-022353-q2k2krnm	268	9	.	.	.
cord-022353-q2k2krnm	269	1	However	however	RB
cord-022353-q2k2krnm	269	2	,	,	,
cord-022353-q2k2krnm	269	3	plasma	plasma	NN
cord-022353-q2k2krnm	269	4	glucose	glucose	NN
cord-022353-q2k2krnm	269	5	determination	determination	NN
cord-022353-q2k2krnm	269	6	is	be	VBZ
cord-022353-q2k2krnm	269	7	acceptable	acceptable	JJ
cord-022353-q2k2krnm	269	8	if	if	IN
cord-022353-q2k2krnm	269	9	delay	delay	NN
cord-022353-q2k2krnm	269	10	of	of	IN
cord-022353-q2k2krnm	269	11	greater	great	JJR
cord-022353-q2k2krnm	269	12	than	than	IN
cord-022353-q2k2krnm	269	13	30	30	CD
cord-022353-q2k2krnm	269	14	minutes	minute	NNS
cord-022353-q2k2krnm	269	15	before	before	IN
cord-022353-q2k2krnm	269	16	separation	separation	NN
cord-022353-q2k2krnm	269	17	of	of	IN
cord-022353-q2k2krnm	269	18	erythrocytes	erythrocyte	NNS
cord-022353-q2k2krnm	269	19	is	be	VBZ
cord-022353-q2k2krnm	269	20	anticipated	anticipate	VBN
cord-022353-q2k2krnm	269	21	.	.	.
cord-022353-q2k2krnm	270	1	In	in	IN
cord-022353-q2k2krnm	270	2	this	this	DT
cord-022353-q2k2krnm	270	3	case	case	NN
cord-022353-q2k2krnm	270	4	,	,	,
cord-022353-q2k2krnm	270	5	fluoride	fluoride	NN
cord-022353-q2k2krnm	270	6	should	should	MD
cord-022353-q2k2krnm	270	7	be	be	VB
cord-022353-q2k2krnm	270	8	used	use	VBN
cord-022353-q2k2krnm	270	9	as	as	IN
cord-022353-q2k2krnm	270	10	the	the	DT
cord-022353-q2k2krnm	270	11	anticoagulant	anticoagulant	NN
cord-022353-q2k2krnm	270	12	because	because	IN
cord-022353-q2k2krnm	270	13	it	-PRON-	PRP
cord-022353-q2k2krnm	270	14	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	270	15	glycolysis	glycolysis	NN
cord-022353-q2k2krnm	270	16	by	by	IN
cord-022353-q2k2krnm	270	17	erythrocytes	erythrocyte	NNS
cord-022353-q2k2krnm	270	18	.	.	.
cord-022353-q2k2krnm	271	1	Blood	blood	NN
cord-022353-q2k2krnm	271	2	glucose	glucose	NN
cord-022353-q2k2krnm	271	3	in	in	IN
cord-022353-q2k2krnm	271	4	mice	mouse	NNS
cord-022353-q2k2krnm	271	5	is	be	VBZ
cord-022353-q2k2krnm	271	6	measured	measure	VBN
cord-022353-q2k2krnm	271	7	using	use	VBG
cord-022353-q2k2krnm	271	8	the	the	DT
cord-022353-q2k2krnm	271	9	hexokinase	hexokinase	NN
cord-022353-q2k2krnm	271	10	or	or	CC
cord-022353-q2k2krnm	271	11	glucose	glucose	NN
cord-022353-q2k2krnm	271	12	oxidase	oxidase	NN
cord-022353-q2k2krnm	271	13	.	.	.
cord-022353-q2k2krnm	272	1	These	these	DT
cord-022353-q2k2krnm	272	2	tests	test	NNS
cord-022353-q2k2krnm	272	3	may	may	MD
cord-022353-q2k2krnm	272	4	be	be	VB
cord-022353-q2k2krnm	272	5	performed	perform	VBN
cord-022353-q2k2krnm	272	6	as	as	IN
cord-022353-q2k2krnm	272	7	an	an	DT
cord-022353-q2k2krnm	272	8	analytical	analytical	JJ
cord-022353-q2k2krnm	272	9	method	method	NN
cord-022353-q2k2krnm	272	10	or	or	CC
cord-022353-q2k2krnm	272	11	by	by	IN
cord-022353-q2k2krnm	272	12	using	use	VBG
cord-022353-q2k2krnm	272	13	glucose	glucose	NN
cord-022353-q2k2krnm	272	14	oxidase	oxidase	NN
cord-022353-q2k2krnm	272	15	coated	coat	VBN
cord-022353-q2k2krnm	272	16	test	test	NN
cord-022353-q2k2krnm	272	17	strips	strip	NNS
cord-022353-q2k2krnm	272	18	(	(	-LRB-
cord-022353-q2k2krnm	272	19	for	for	IN
cord-022353-q2k2krnm	272	20	urine	urine	NN
cord-022353-q2k2krnm	272	21	glucose	glucose	NN
cord-022353-q2k2krnm	272	22	)	)	-RRB-
cord-022353-q2k2krnm	272	23	,	,	,
cord-022353-q2k2krnm	272	24	or	or	CC
cord-022353-q2k2krnm	272	25	small	small	JJ
cord-022353-q2k2krnm	272	26	portable	portable	JJ
cord-022353-q2k2krnm	272	27	analyzers	analyzer	NNS
cord-022353-q2k2krnm	272	28	(	(	-LRB-
cord-022353-q2k2krnm	272	29	Seidelmann	Seidelmann	NNP
cord-022353-q2k2krnm	272	30	et	et	NNP
cord-022353-q2k2krnm	272	31	al	al	NNP
cord-022353-q2k2krnm	272	32	.	.	NNP
cord-022353-q2k2krnm	272	33	2005	2005	CD
cord-022353-q2k2krnm	272	34	)	)	-RRB-
cord-022353-q2k2krnm	272	35	.	.	.
cord-022353-q2k2krnm	273	1	Assessment	assessment	NN
cord-022353-q2k2krnm	273	2	of	of	IN
cord-022353-q2k2krnm	273	3	long	long	JJ
cord-022353-q2k2krnm	273	4	-	-	HYPH
cord-022353-q2k2krnm	273	5	term	term	NN
cord-022353-q2k2krnm	273	6	average	average	JJ
cord-022353-q2k2krnm	273	7	blood	blood	NN
cord-022353-q2k2krnm	273	8	glucose	glucose	NN
cord-022353-q2k2krnm	273	9	levels	level	NNS
cord-022353-q2k2krnm	273	10	in	in	IN
cord-022353-q2k2krnm	273	11	mice	mice	NN
cord-022353-q2k2krnm	273	12	is	be	VBZ
cord-022353-q2k2krnm	273	13	also	also	RB
cord-022353-q2k2krnm	273	14	available	available	JJ
cord-022353-q2k2krnm	273	15	by	by	IN
cord-022353-q2k2krnm	273	16	RIAs	RIAs	NNP
cord-022353-q2k2krnm	273	17	measuring	measure	VBG
cord-022353-q2k2krnm	273	18	glycosylated	glycosylated	JJ
cord-022353-q2k2krnm	273	19	hemoglobin	hemoglobin	NN
cord-022353-q2k2krnm	273	20	and	and	CC
cord-022353-q2k2krnm	273	21	glycosylated	glycosylated	JJ
cord-022353-q2k2krnm	273	22	serum	serum	NN
cord-022353-q2k2krnm	273	23	proteins	protein	NNS
cord-022353-q2k2krnm	273	24	(	(	-LRB-
cord-022353-q2k2krnm	273	25	collectively	collectively	RB
cord-022353-q2k2krnm	273	26	known	know	VBN
cord-022353-q2k2krnm	273	27	as	as	IN
cord-022353-q2k2krnm	273	28	fructosamines	fructosamine	NNS
cord-022353-q2k2krnm	273	29	)	)	-RRB-
cord-022353-q2k2krnm	274	1	(	(	-LRB-
cord-022353-q2k2krnm	274	2	Gould	Gould	NNP
cord-022353-q2k2krnm	274	3	et	et	NNP
cord-022353-q2k2krnm	274	4	al	al	NNP
cord-022353-q2k2krnm	274	5	.	.	NNP
cord-022353-q2k2krnm	274	6	1986	1986	CD
cord-022353-q2k2krnm	274	7	)	)	-RRB-
cord-022353-q2k2krnm	274	8	.	.	.
cord-022353-q2k2krnm	275	1	The	the	DT
cord-022353-q2k2krnm	275	2	Mouse	Mouse	NNP
cord-022353-q2k2krnm	275	3	Phenome	Phenome	NNP
cord-022353-q2k2krnm	275	4	Database	Database	NNP
cord-022353-q2k2krnm	275	5	lists	list	VBZ
cord-022353-q2k2krnm	275	6	serum	serum	VBP
cord-022353-q2k2krnm	275	7	glucose	glucose	NN
cord-022353-q2k2krnm	275	8	levels	level	NNS
cord-022353-q2k2krnm	275	9	of	of	IN
cord-022353-q2k2krnm	275	10	41	41	CD
cord-022353-q2k2krnm	275	11	strains	strain	NNS
cord-022353-q2k2krnm	275	12	with	with	IN
cord-022353-q2k2krnm	275	13	blood	blood	NN
cord-022353-q2k2krnm	275	14	collected	collect	VBN
cord-022353-q2k2krnm	275	15	after	after	IN
cord-022353-q2k2krnm	275	16	a	a	DT
cord-022353-q2k2krnm	275	17	4-h	4-h	CD
cord-022353-q2k2krnm	275	18	fast	fast	NN
cord-022353-q2k2krnm	275	19	on	on	IN
cord-022353-q2k2krnm	275	20	7	7	CD
cord-022353-q2k2krnm	275	21	-	-	SYM
cord-022353-q2k2krnm	275	22	9	9	CD
cord-022353-q2k2krnm	275	23	week	week	NN
cord-022353-q2k2krnm	275	24	old	old	JJ
cord-022353-q2k2krnm	275	25	males	male	NNS
cord-022353-q2k2krnm	275	26	and	and	CC
cord-022353-q2k2krnm	275	27	females	female	NNS
cord-022353-q2k2krnm	275	28	on	on	IN
cord-022353-q2k2krnm	275	29	a	a	DT
cord-022353-q2k2krnm	275	30	standard	standard	JJ
cord-022353-q2k2krnm	275	31	laboratory	laboratory	NN
cord-022353-q2k2krnm	275	32	diet	diet	NN
cord-022353-q2k2krnm	275	33	.	.	.
cord-022353-q2k2krnm	276	1	For	for	IN
cord-022353-q2k2krnm	276	2	all	all	DT
cord-022353-q2k2krnm	276	3	mice	mouse	NNS
cord-022353-q2k2krnm	276	4	,	,	,
cord-022353-q2k2krnm	276	5	the	the	DT
cord-022353-q2k2krnm	276	6	overall	overall	JJ
cord-022353-q2k2krnm	276	7	mean	mean	NN
cord-022353-q2k2krnm	276	8	was	be	VBD
cord-022353-q2k2krnm	276	9	179	179	CD
cord-022353-q2k2krnm	276	10	+	+	SYM
cord-022353-q2k2krnm	276	11	30.9	30.9	CD
cord-022353-q2k2krnm	276	12	mg	mg	NNP
cord-022353-q2k2krnm	276	13	/	/	SYM
cord-022353-q2k2krnm	276	14	dl	dl	NNP
cord-022353-q2k2krnm	276	15	(	(	-LRB-
cord-022353-q2k2krnm	276	16	Naggert	Naggert	NNP
cord-022353-q2k2krnm	276	17	et	et	NNP
cord-022353-q2k2krnm	276	18	al	al	NNP
cord-022353-q2k2krnm	276	19	.	.	NNP
cord-022353-q2k2krnm	276	20	2003	2003	CD
cord-022353-q2k2krnm	276	21	)	)	-RRB-
cord-022353-q2k2krnm	276	22	,	,	,
cord-022353-q2k2krnm	276	23	but	but	CC
cord-022353-q2k2krnm	276	24	blood	blood	NN
cord-022353-q2k2krnm	276	25	glucose	glucose	NN
cord-022353-q2k2krnm	276	26	levels	level	NNS
cord-022353-q2k2krnm	276	27	varied	vary	VBN
cord-022353-q2k2krnm	276	28	with	with	IN
cord-022353-q2k2krnm	276	29	age	age	NN
cord-022353-q2k2krnm	276	30	,	,	,
cord-022353-q2k2krnm	276	31	sex	sex	NN
cord-022353-q2k2krnm	276	32	,	,	,
cord-022353-q2k2krnm	276	33	and	and	CC
cord-022353-q2k2krnm	276	34	strain	strain	VB
cord-022353-q2k2krnm	276	35	.	.	.
cord-022353-q2k2krnm	277	1	Females	female	NNS
cord-022353-q2k2krnm	277	2	of	of	IN
cord-022353-q2k2krnm	277	3	a	a	DT
cord-022353-q2k2krnm	277	4	strain	strain	NN
cord-022353-q2k2krnm	277	5	tended	tend	VBD
cord-022353-q2k2krnm	277	6	to	to	TO
cord-022353-q2k2krnm	277	7	have	have	VB
cord-022353-q2k2krnm	277	8	lower	low	JJR
cord-022353-q2k2krnm	277	9	levels	level	NNS
cord-022353-q2k2krnm	277	10	than	than	IN
cord-022353-q2k2krnm	277	11	males	male	NNS
cord-022353-q2k2krnm	277	12	,	,	,
cord-022353-q2k2krnm	277	13	with	with	IN
cord-022353-q2k2krnm	277	14	LP	LP	NNP
cord-022353-q2k2krnm	277	15	/	/	SYM
cord-022353-q2k2krnm	277	16	J	J	NNP
cord-022353-q2k2krnm	277	17	mice	mouse	NNS
cord-022353-q2k2krnm	277	18	showing	show	VBG
cord-022353-q2k2krnm	277	19	the	the	DT
cord-022353-q2k2krnm	277	20	lowest	low	JJS
cord-022353-q2k2krnm	277	21	values	value	NNS
cord-022353-q2k2krnm	277	22	(	(	-LRB-
cord-022353-q2k2krnm	277	23	F	f	NN
cord-022353-q2k2krnm	277	24	=	=	SYM
cord-022353-q2k2krnm	277	25	125	125	CD
cord-022353-q2k2krnm	277	26	+	+	SYM
cord-022353-q2k2krnm	277	27	22.0	22.0	CD
cord-022353-q2k2krnm	277	28	and	and	CC
cord-022353-q2k2krnm	277	29	M	M	NNP
cord-022353-q2k2krnm	278	1	=	=	NFP
cord-022353-q2k2krnm	278	2	146	146	CD
cord-022353-q2k2krnm	278	3	_	_	NN
cord-022353-q2k2krnm	278	4	+	+	SYM
cord-022353-q2k2krnm	278	5	18.8	18.8	CD
cord-022353-q2k2krnm	278	6	mg	mg	NNP
cord-022353-q2k2krnm	278	7	/	/	SYM
cord-022353-q2k2krnm	278	8	dl	dl	NNP
cord-022353-q2k2krnm	278	9	)	)	-RRB-
cord-022353-q2k2krnm	278	10	and	and	CC
cord-022353-q2k2krnm	279	1	C57B1/10J	C57B1/10J	NNP
cord-022353-q2k2krnm	279	2	mice	mouse	NNS
cord-022353-q2k2krnm	279	3	showing	show	VBG
cord-022353-q2k2krnm	279	4	the	the	DT
cord-022353-q2k2krnm	279	5	highest	high	JJS
cord-022353-q2k2krnm	279	6	values	value	NNS
cord-022353-q2k2krnm	280	1	(	(	-LRB-
cord-022353-q2k2krnm	280	2	F	F	NNP
cord-022353-q2k2krnm	280	3	=	=	SYM
cord-022353-q2k2krnm	280	4	230	230	CD
cord-022353-q2k2krnm	280	5	_	_	NN
cord-022353-q2k2krnm	280	6	+	+	SYM
cord-022353-q2k2krnm	280	7	25.5	25.5	CD
cord-022353-q2k2krnm	281	1	;	;	:
cord-022353-q2k2krnm	281	2	M	M	NNP
cord-022353-q2k2krnm	281	3	=	=	SYM
cord-022353-q2k2krnm	281	4	263	263	CD
cord-022353-q2k2krnm	281	5	_	_	NN
cord-022353-q2k2krnm	281	6	+	+	SYM
cord-022353-q2k2krnm	281	7	57.3	57.3	CD
cord-022353-q2k2krnm	281	8	mg	mg	NNP
cord-022353-q2k2krnm	281	9	/	/	SYM
cord-022353-q2k2krnm	281	10	dl	dl	NNP
cord-022353-q2k2krnm	281	11	)	)	-RRB-
cord-022353-q2k2krnm	281	12	.	.	.
cord-022353-q2k2krnm	282	1	In	in	IN
cord-022353-q2k2krnm	282	2	mice	mice	NN
cord-022353-q2k2krnm	282	3	serum	serum	NN
cord-022353-q2k2krnm	282	4	glucose	glucose	NN
cord-022353-q2k2krnm	282	5	levels	level	NNS
cord-022353-q2k2krnm	282	6	decrease	decrease	VBP
cord-022353-q2k2krnm	282	7	between	between	IN
cord-022353-q2k2krnm	282	8	the	the	DT
cord-022353-q2k2krnm	282	9	3rd	3rd	JJ
cord-022353-q2k2krnm	282	10	and	and	CC
cord-022353-q2k2krnm	282	11	12th	12th	JJ
cord-022353-q2k2krnm	282	12	month	month	NN
cord-022353-q2k2krnm	282	13	of	of	IN
cord-022353-q2k2krnm	282	14	age	age	NN
cord-022353-q2k2krnm	282	15	and	and	CC
cord-022353-q2k2krnm	282	16	in	in	IN
cord-022353-q2k2krnm	282	17	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	282	18	and	and	CC
cord-022353-q2k2krnm	282	19	BALB	BALB	NNP
cord-022353-q2k2krnm	282	20	/	/	SYM
cord-022353-q2k2krnm	282	21	c	c	NN
cord-022353-q2k2krnm	282	22	strains	strain	VBZ
cord-022353-q2k2krnm	282	23	the	the	DT
cord-022353-q2k2krnm	282	24	glucose	glucose	NN
cord-022353-q2k2krnm	282	25	level	level	NN
cord-022353-q2k2krnm	282	26	rises	rise	VBZ
cord-022353-q2k2krnm	282	27	again	again	RB
cord-022353-q2k2krnm	282	28	after	after	IN
cord-022353-q2k2krnm	282	29	24	24	CD
cord-022353-q2k2krnm	282	30	months	month	NNS
cord-022353-q2k2krnm	282	31	(	(	-LRB-
cord-022353-q2k2krnm	282	32	Loeb	Loeb	NNP
cord-022353-q2k2krnm	282	33	1997	1997	CD
cord-022353-q2k2krnm	282	34	)	)	-RRB-
cord-022353-q2k2krnm	282	35	.	.	.
cord-022353-q2k2krnm	283	1	Serum	serum	NN
cord-022353-q2k2krnm	283	2	or	or	CC
cord-022353-q2k2krnm	283	3	plasma	plasma	NN
cord-022353-q2k2krnm	283	4	glucose	glucose	NN
cord-022353-q2k2krnm	283	5	levels	level	NNS
cord-022353-q2k2krnm	283	6	may	may	MD
cord-022353-q2k2krnm	283	7	also	also	RB
cord-022353-q2k2krnm	283	8	vary	vary	VB
cord-022353-q2k2krnm	283	9	depending	depend	VBG
cord-022353-q2k2krnm	283	10	on	on	IN
cord-022353-q2k2krnm	283	11	the	the	DT
cord-022353-q2k2krnm	283	12	site	site	NN
cord-022353-q2k2krnm	283	13	of	of	IN
cord-022353-q2k2krnm	283	14	collection	collection	NN
cord-022353-q2k2krnm	283	15	and	and	CC
cord-022353-q2k2krnm	283	16	anesthetic	anesthetic	NN
cord-022353-q2k2krnm	283	17	used	use	VBN
cord-022353-q2k2krnm	283	18	(	(	-LRB-
cord-022353-q2k2krnm	283	19	Quimby	Quimby	NNP
cord-022353-q2k2krnm	283	20	1999b	1999b	CD
cord-022353-q2k2krnm	283	21	)	)	-RRB-
cord-022353-q2k2krnm	283	22	.	.	.
cord-022353-q2k2krnm	284	1	Patrick	Patrick	NNP
cord-022353-q2k2krnm	284	2	et	et	NNP
cord-022353-q2k2krnm	284	3	al	al	NNP
cord-022353-q2k2krnm	284	4	.	.	.
cord-022353-q2k2krnm	285	1	(	(	-LRB-
cord-022353-q2k2krnm	285	2	1983	1983	CD
cord-022353-q2k2krnm	285	3	)	)	-RRB-
cord-022353-q2k2krnm	285	4	found	find	VBD
cord-022353-q2k2krnm	285	5	that	that	IN
cord-022353-q2k2krnm	285	6	compared	compare	VBN
cord-022353-q2k2krnm	285	7	to	to	IN
cord-022353-q2k2krnm	285	8	jugular	jugular	NNP
cord-022353-q2k2krnm	285	9	vein	vein	NN
cord-022353-q2k2krnm	285	10	collection	collection	NN
cord-022353-q2k2krnm	285	11	,	,	,
cord-022353-q2k2krnm	285	12	cardiac	cardiac	JJ
cord-022353-q2k2krnm	285	13	puncture	puncture	NN
cord-022353-q2k2krnm	285	14	was	be	VBD
cord-022353-q2k2krnm	285	15	associated	associate	VBN
cord-022353-q2k2krnm	285	16	with	with	IN
cord-022353-q2k2krnm	285	17	higher	high	JJR
cord-022353-q2k2krnm	285	18	blood	blood	NN
cord-022353-q2k2krnm	285	19	glucose	glucose	NN
cord-022353-q2k2krnm	285	20	.	.	.
cord-022353-q2k2krnm	286	1	Differences	difference	NNS
cord-022353-q2k2krnm	286	2	associated	associate	VBN
cord-022353-q2k2krnm	286	3	with	with	IN
cord-022353-q2k2krnm	286	4	the	the	DT
cord-022353-q2k2krnm	286	5	method	method	NN
cord-022353-q2k2krnm	286	6	of	of	IN
cord-022353-q2k2krnm	286	7	anesthesia	anesthesia	NN
cord-022353-q2k2krnm	286	8	are	be	VBP
cord-022353-q2k2krnm	286	9	also	also	RB
cord-022353-q2k2krnm	286	10	important	important	JJ
cord-022353-q2k2krnm	286	11	.	.	.
cord-022353-q2k2krnm	287	1	Higher	high	JJR
cord-022353-q2k2krnm	287	2	plasma	plasma	NN
cord-022353-q2k2krnm	287	3	glucose	glucose	NN
cord-022353-q2k2krnm	287	4	levels	level	NNS
cord-022353-q2k2krnm	287	5	are	be	VBP
cord-022353-q2k2krnm	287	6	reported	report	VBN
cord-022353-q2k2krnm	287	7	after	after	IN
cord-022353-q2k2krnm	287	8	tail	tail	NN
cord-022353-q2k2krnm	287	9	vein	vein	NN
cord-022353-q2k2krnm	287	10	sampling	sampling	NN
cord-022353-q2k2krnm	287	11	under	under	IN
cord-022353-q2k2krnm	287	12	either	either	DT
cord-022353-q2k2krnm	287	13	pentobarbital	pentobarbital	JJ
cord-022353-q2k2krnm	287	14	or	or	CC
cord-022353-q2k2krnm	287	15	methoxyflurane	methoxyflurane	NN
cord-022353-q2k2krnm	287	16	compared	compare	VBN
cord-022353-q2k2krnm	287	17	to	to	IN
cord-022353-q2k2krnm	287	18	sampling	sampling	NN
cord-022353-q2k2krnm	287	19	conscious	conscious	JJ
cord-022353-q2k2krnm	287	20	mice	mouse	NNS
cord-022353-q2k2krnm	287	21	(	(	-LRB-
cord-022353-q2k2krnm	287	22	Chuang	Chuang	NNP
cord-022353-q2k2krnm	287	23	and	and	CC
cord-022353-q2k2krnm	287	24	Luo	Luo	NNP
cord-022353-q2k2krnm	287	25	1997	1997	CD
cord-022353-q2k2krnm	287	26	)	)	-RRB-
cord-022353-q2k2krnm	287	27	.	.	.
cord-022353-q2k2krnm	288	1	Plasma	plasma	NN
cord-022353-q2k2krnm	288	2	glucose	glucose	NN
cord-022353-q2k2krnm	288	3	levels	level	NNS
cord-022353-q2k2krnm	288	4	were	be	VBD
cord-022353-q2k2krnm	288	5	higher	high	JJR
cord-022353-q2k2krnm	288	6	after	after	IN
cord-022353-q2k2krnm	288	7	orbital	orbital	JJ
cord-022353-q2k2krnm	288	8	plexus	plexus	NN
cord-022353-q2k2krnm	288	9	sampling	sampling	NN
cord-022353-q2k2krnm	288	10	of	of	IN
cord-022353-q2k2krnm	288	11	mice	mouse	NNS
cord-022353-q2k2krnm	288	12	if	if	IN
cord-022353-q2k2krnm	288	13	pentobarbital	pentobarbital	JJ
cord-022353-q2k2krnm	288	14	or	or	CC
cord-022353-q2k2krnm	288	15	proparacaine	proparacaine	NN
cord-022353-q2k2krnm	288	16	hydrochloride	hydrochloride	NN
cord-022353-q2k2krnm	288	17	was	be	VBD
cord-022353-q2k2krnm	288	18	provided	provide	VBN
cord-022353-q2k2krnm	288	19	.	.	.
cord-022353-q2k2krnm	289	1	Methoxyflurane	Methoxyflurane	NNP
cord-022353-q2k2krnm	289	2	had	have	VBD
cord-022353-q2k2krnm	289	3	no	no	DT
cord-022353-q2k2krnm	289	4	glucose	glucose	NN
cord-022353-q2k2krnm	289	5	elevating	elevate	VBG
cord-022353-q2k2krnm	289	6	effect	effect	NN
cord-022353-q2k2krnm	289	7	on	on	IN
cord-022353-q2k2krnm	289	8	samples	sample	NNS
cord-022353-q2k2krnm	289	9	collected	collect	VBN
cord-022353-q2k2krnm	289	10	from	from	IN
cord-022353-q2k2krnm	289	11	the	the	DT
cord-022353-q2k2krnm	289	12	orbital	orbital	JJ
cord-022353-q2k2krnm	289	13	plexus	plexus	NN
cord-022353-q2k2krnm	289	14	;	;	:
cord-022353-q2k2krnm	289	15	however	however	RB
cord-022353-q2k2krnm	289	16	,	,	,
cord-022353-q2k2krnm	289	17	in	in	IN
cord-022353-q2k2krnm	289	18	conscious	conscious	JJ
cord-022353-q2k2krnm	289	19	animals	animal	NNS
cord-022353-q2k2krnm	289	20	,	,	,
cord-022353-q2k2krnm	289	21	plasma	plasma	NN
cord-022353-q2k2krnm	289	22	glucose	glucose	NN
cord-022353-q2k2krnm	289	23	levels	level	NNS
cord-022353-q2k2krnm	289	24	were	be	VBD
cord-022353-q2k2krnm	289	25	higher	high	JJR
cord-022353-q2k2krnm	289	26	in	in	IN
cord-022353-q2k2krnm	289	27	blood	blood	NN
cord-022353-q2k2krnm	289	28	collected	collect	VBN
cord-022353-q2k2krnm	289	29	by	by	IN
cord-022353-q2k2krnm	289	30	retro	retro	JJ
cord-022353-q2k2krnm	289	31	-	-	HYPH
cord-022353-q2k2krnm	289	32	orbital	orbital	JJ
cord-022353-q2k2krnm	289	33	sinus	sinus	NN
cord-022353-q2k2krnm	289	34	compared	compare	VBN
cord-022353-q2k2krnm	289	35	to	to	IN
cord-022353-q2k2krnm	289	36	tail	tail	NN
cord-022353-q2k2krnm	289	37	bleeding	bleeding	NN
cord-022353-q2k2krnm	289	38	.	.	.
cord-022353-q2k2krnm	290	1	Hyperglycemia	hyperglycemia	NN
cord-022353-q2k2krnm	290	2	(	(	-LRB-
cord-022353-q2k2krnm	290	3	increased	increase	VBN
cord-022353-q2k2krnm	290	4	blood	blood	NN
cord-022353-q2k2krnm	290	5	glucose	glucose	NN
cord-022353-q2k2krnm	290	6	levels	level	NNS
cord-022353-q2k2krnm	290	7	)	)	-RRB-
cord-022353-q2k2krnm	290	8	in	in	IN
cord-022353-q2k2krnm	290	9	the	the	DT
cord-022353-q2k2krnm	290	10	mouse	mouse	NN
cord-022353-q2k2krnm	290	11	can	can	MD
cord-022353-q2k2krnm	290	12	be	be	VB
cord-022353-q2k2krnm	290	13	due	due	JJ
cord-022353-q2k2krnm	290	14	to	to	IN
cord-022353-q2k2krnm	290	15	increased	increase	VBN
cord-022353-q2k2krnm	290	16	peripheral	peripheral	JJ
cord-022353-q2k2krnm	290	17	resistance	resistance	NN
cord-022353-q2k2krnm	290	18	of	of	IN
cord-022353-q2k2krnm	290	19	tissues	tissue	NNS
cord-022353-q2k2krnm	290	20	to	to	IN
cord-022353-q2k2krnm	290	21	insulin	insulin	NN
cord-022353-q2k2krnm	290	22	(	(	-LRB-
cord-022353-q2k2krnm	290	23	such	such	JJ
cord-022353-q2k2krnm	290	24	as	as	IN
cord-022353-q2k2krnm	290	25	with	with	IN
cord-022353-q2k2krnm	290	26	exogenous	exogenous	JJ
cord-022353-q2k2krnm	290	27	corticosteroid	corticosteroid	NNP
cord-022353-q2k2krnm	290	28	administration	administration	NN
cord-022353-q2k2krnm	290	29	,	,	,
cord-022353-q2k2krnm	290	30	increased	increase	VBD
cord-022353-q2k2krnm	290	31	endogenous	endogenous	JJ
cord-022353-q2k2krnm	290	32	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	290	33	release	release	NN
cord-022353-q2k2krnm	290	34	,	,	,
cord-022353-q2k2krnm	290	35	glucagons	glucagons	NNP
cord-022353-q2k2krnm	290	36	administration	administration	NN
cord-022353-q2k2krnm	290	37	,	,	,
cord-022353-q2k2krnm	290	38	and	and	CC
cord-022353-q2k2krnm	290	39	GH	GH	NNP
cord-022353-q2k2krnm	290	40	administration	administration	NN
cord-022353-q2k2krnm	290	41	)	)	-RRB-
cord-022353-q2k2krnm	290	42	,	,	,
cord-022353-q2k2krnm	290	43	and	and	CC
cord-022353-q2k2krnm	290	44	diabetes	diabetes	NN
cord-022353-q2k2krnm	290	45	(	(	-LRB-
cord-022353-q2k2krnm	290	46	see	see	VB
cord-022353-q2k2krnm	290	47	discussion	discussion	NN
cord-022353-q2k2krnm	290	48	later	later	RB
cord-022353-q2k2krnm	290	49	)	)	-RRB-
cord-022353-q2k2krnm	290	50	.	.	.
cord-022353-q2k2krnm	291	1	Hypoglycemia	hypoglycemia	NN
cord-022353-q2k2krnm	291	2	(	(	-LRB-
cord-022353-q2k2krnm	291	3	decreased	decrease	VBD
cord-022353-q2k2krnm	291	4	blood	blood	NN
cord-022353-q2k2krnm	291	5	glucose	glucose	NN
cord-022353-q2k2krnm	291	6	levels	level	NNS
cord-022353-q2k2krnm	291	7	)	)	-RRB-
cord-022353-q2k2krnm	291	8	can	can	MD
cord-022353-q2k2krnm	291	9	be	be	VB
cord-022353-q2k2krnm	291	10	due	due	JJ
cord-022353-q2k2krnm	291	11	to	to	IN
cord-022353-q2k2krnm	291	12	excessive	excessive	JJ
cord-022353-q2k2krnm	291	13	circulating	circulate	VBG
cord-022353-q2k2krnm	291	14	insulin	insulin	NN
cord-022353-q2k2krnm	291	15	(	(	-LRB-
cord-022353-q2k2krnm	291	16	such	such	JJ
cord-022353-q2k2krnm	291	17	as	as	IN
cord-022353-q2k2krnm	291	18	with	with	IN
cord-022353-q2k2krnm	291	19	excessive	excessive	JJ
cord-022353-q2k2krnm	291	20	insulin	insulin	NN
cord-022353-q2k2krnm	291	21	administration	administration	NN
cord-022353-q2k2krnm	291	22	and	and	CC
cord-022353-q2k2krnm	291	23	transgenic	transgenic	JJ
cord-022353-q2k2krnm	291	24	mice	mouse	NNS
cord-022353-q2k2krnm	291	25	with	with	IN
cord-022353-q2k2krnm	291	26	[	[	-LRB-
cord-022353-q2k2krnm	291	27	3-cell	3-cell	CD
cord-022353-q2k2krnm	291	28	tumors	tumor	NNS
cord-022353-q2k2krnm	291	29	of	of	IN
cord-022353-q2k2krnm	291	30	the	the	DT
cord-022353-q2k2krnm	291	31	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	291	32	islets	islet	NNS
cord-022353-q2k2krnm	291	33	)	)	-RRB-
cord-022353-q2k2krnm	291	34	,	,	,
cord-022353-q2k2krnm	291	35	reduced	reduce	VBN
cord-022353-q2k2krnm	291	36	glycogen	glycogen	NN
cord-022353-q2k2krnm	291	37	stores	store	NNS
cord-022353-q2k2krnm	291	38	(	(	-LRB-
cord-022353-q2k2krnm	291	39	such	such	JJ
cord-022353-q2k2krnm	291	40	as	as	IN
cord-022353-q2k2krnm	291	41	with	with	IN
cord-022353-q2k2krnm	291	42	advanced	advanced	JJ
cord-022353-q2k2krnm	291	43	liver	liver	NN
cord-022353-q2k2krnm	291	44	disease	disease	NN
cord-022353-q2k2krnm	291	45	)	)	-RRB-
cord-022353-q2k2krnm	291	46	,	,	,
cord-022353-q2k2krnm	291	47	excessive	excessive	JJ
cord-022353-q2k2krnm	291	48	glucose	glucose	NN
cord-022353-q2k2krnm	291	49	use	use	NN
cord-022353-q2k2krnm	291	50	(	(	-LRB-
cord-022353-q2k2krnm	291	51	such	such	JJ
cord-022353-q2k2krnm	291	52	as	as	IN
cord-022353-q2k2krnm	291	53	with	with	IN
cord-022353-q2k2krnm	291	54	pregnancy	pregnancy	NN
cord-022353-q2k2krnm	291	55	,	,	,
cord-022353-q2k2krnm	291	56	septicemia	septicemia	NN
cord-022353-q2k2krnm	291	57	,	,	,
cord-022353-q2k2krnm	291	58	and	and	CC
cord-022353-q2k2krnm	291	59	neoplasia	neoplasia	NN
cord-022353-q2k2krnm	291	60	)	)	-RRB-
cord-022353-q2k2krnm	291	61	,	,	,
cord-022353-q2k2krnm	291	62	and	and	CC
cord-022353-q2k2krnm	291	63	reduced	reduce	VBN
cord-022353-q2k2krnm	291	64	glucose	glucose	NN
cord-022353-q2k2krnm	291	65	intake	intake	NN
cord-022353-q2k2krnm	291	66	(	(	-LRB-
cord-022353-q2k2krnm	291	67	such	such	JJ
cord-022353-q2k2krnm	291	68	as	as	IN
cord-022353-q2k2krnm	291	69	with	with	IN
cord-022353-q2k2krnm	291	70	starvation	starvation	NN
cord-022353-q2k2krnm	291	71	and	and	CC
cord-022353-q2k2krnm	291	72	diseases	disease	NNS
cord-022353-q2k2krnm	291	73	of	of	IN
cord-022353-q2k2krnm	291	74	malabsorption	malabsorption	NN
cord-022353-q2k2krnm	291	75	)	)	-RRB-
cord-022353-q2k2krnm	291	76	.	.	.
cord-022353-q2k2krnm	292	1	Diabetes	diabetes	NN
cord-022353-q2k2krnm	292	2	in	in	IN
cord-022353-q2k2krnm	292	3	mice	mouse	NNS
cord-022353-q2k2krnm	292	4	is	be	VBZ
cord-022353-q2k2krnm	292	5	defined	define	VBN
cord-022353-q2k2krnm	292	6	as	as	IN
cord-022353-q2k2krnm	292	7	persistent	persistent	JJ
cord-022353-q2k2krnm	292	8	blood	blood	NN
cord-022353-q2k2krnm	292	9	glucose	glucose	NN
cord-022353-q2k2krnm	292	10	levels	level	NNS
cord-022353-q2k2krnm	292	11	of	of	IN
cord-022353-q2k2krnm	292	12	greater	great	JJR
cord-022353-q2k2krnm	292	13	than	than	IN
cord-022353-q2k2krnm	292	14	300	300	CD
cord-022353-q2k2krnm	292	15	mg	mg	NNP
cord-022353-q2k2krnm	292	16	/	/	SYM
cord-022353-q2k2krnm	292	17	dl	dl	NN
cord-022353-q2k2krnm	292	18	in	in	IN
cord-022353-q2k2krnm	292	19	fasting	fast	VBG
cord-022353-q2k2krnm	292	20	mice	mouse	NNS
cord-022353-q2k2krnm	292	21	.	.	.
cord-022353-q2k2krnm	293	1	This	this	DT
cord-022353-q2k2krnm	293	2	level	level	NN
cord-022353-q2k2krnm	293	3	also	also	RB
cord-022353-q2k2krnm	293	4	corresponds	correspond	VBZ
cord-022353-q2k2krnm	293	5	to	to	IN
cord-022353-q2k2krnm	293	6	the	the	DT
cord-022353-q2k2krnm	293	7	renal	renal	JJ
cord-022353-q2k2krnm	293	8	threshold	threshold	NN
cord-022353-q2k2krnm	293	9	for	for	IN
cord-022353-q2k2krnm	293	10	glucose	glucose	NN
cord-022353-q2k2krnm	293	11	urine	urine	NN
cord-022353-q2k2krnm	293	12	excretion	excretion	NN
cord-022353-q2k2krnm	293	13	in	in	IN
cord-022353-q2k2krnm	293	14	mice	mouse	NNS
cord-022353-q2k2krnm	293	15	,	,	,
cord-022353-q2k2krnm	293	16	so	so	CC
cord-022353-q2k2krnm	293	17	urine	urine	NN
cord-022353-q2k2krnm	293	18	glucose	glucose	NN
cord-022353-q2k2krnm	293	19	assessment	assessment	NN
cord-022353-q2k2krnm	293	20	is	be	VBZ
cord-022353-q2k2krnm	293	21	useful	useful	JJ
cord-022353-q2k2krnm	293	22	in	in	IN
cord-022353-q2k2krnm	293	23	this	this	DT
cord-022353-q2k2krnm	293	24	regard	regard	NN
cord-022353-q2k2krnm	293	25	for	for	IN
cord-022353-q2k2krnm	293	26	mice	mouse	NNS
cord-022353-q2k2krnm	293	27	.	.	.
cord-022353-q2k2krnm	294	1	Nonobese	nonobese	JJ
cord-022353-q2k2krnm	294	2	diabetic	diabetic	JJ
cord-022353-q2k2krnm	294	3	mice	mouse	NNS
cord-022353-q2k2krnm	294	4	(	(	-LRB-
cord-022353-q2k2krnm	294	5	a	a	DT
cord-022353-q2k2krnm	294	6	model	model	NN
cord-022353-q2k2krnm	294	7	of	of	IN
cord-022353-q2k2krnm	294	8	type	type	NN
cord-022353-q2k2krnm	294	9	1	1	CD
cord-022353-q2k2krnm	294	10	diabetes	diabetes	NN
cord-022353-q2k2krnm	294	11	)	)	-RRB-
cord-022353-q2k2krnm	294	12	have	have	VBP
cord-022353-q2k2krnm	294	13	nonfasting	nonfaste	VBG
cord-022353-q2k2krnm	294	14	plasma	plasma	NN
cord-022353-q2k2krnm	294	15	glucose	glucose	NN
cord-022353-q2k2krnm	294	16	levels	level	NNS
cord-022353-q2k2krnm	294	17	in	in	IN
cord-022353-q2k2krnm	294	18	young	young	JJ
cord-022353-q2k2krnm	294	19	prediabetic	prediabetic	JJ
cord-022353-q2k2krnm	294	20	mice	mouse	NNS
cord-022353-q2k2krnm	294	21	between	between	IN
cord-022353-q2k2krnm	294	22	130	130	CD
cord-022353-q2k2krnm	294	23	-	-	SYM
cord-022353-q2k2krnm	294	24	180	180	CD
cord-022353-q2k2krnm	294	25	mg	mg	NNP
cord-022353-q2k2krnm	294	26	/	/	SYM
cord-022353-q2k2krnm	294	27	dl	dl	NNP
cord-022353-q2k2krnm	294	28	,	,	,
cord-022353-q2k2krnm	294	29	which	which	WDT
cord-022353-q2k2krnm	294	30	rises	rise	VBZ
cord-022353-q2k2krnm	294	31	to	to	IN
cord-022353-q2k2krnm	294	32	>	>	XX
cord-022353-q2k2krnm	295	1	300	300	CD
cord-022353-q2k2krnm	295	2	mg	mg	NNP
cord-022353-q2k2krnm	295	3	/	/	SYM
cord-022353-q2k2krnm	295	4	dl	dl	NN
cord-022353-q2k2krnm	295	5	between	between	IN
cord-022353-q2k2krnm	295	6	10	10	CD
cord-022353-q2k2krnm	295	7	-	-	SYM
cord-022353-q2k2krnm	295	8	30	30	CD
cord-022353-q2k2krnm	295	9	weeks	week	NNS
cord-022353-q2k2krnm	295	10	of	of	IN
cord-022353-q2k2krnm	295	11	age	age	NN
cord-022353-q2k2krnm	295	12	(	(	-LRB-
cord-022353-q2k2krnm	295	13	Leiter	Leiter	NNP
cord-022353-q2k2krnm	295	14	1997	1997	CD
cord-022353-q2k2krnm	295	15	)	)	-RRB-
cord-022353-q2k2krnm	295	16	.	.	.
cord-022353-q2k2krnm	296	1	Genetically	genetically	RB
cord-022353-q2k2krnm	296	2	modified	modify	VBN
cord-022353-q2k2krnm	296	3	mice	mouse	NNS
cord-022353-q2k2krnm	296	4	have	have	VBP
cord-022353-q2k2krnm	296	5	been	be	VBN
cord-022353-q2k2krnm	296	6	identified	identify	VBN
cord-022353-q2k2krnm	296	7	for	for	IN
cord-022353-q2k2krnm	296	8	virtually	virtually	RB
cord-022353-q2k2krnm	296	9	every	every	DT
cord-022353-q2k2krnm	296	10	ligand	ligand	NN
cord-022353-q2k2krnm	296	11	and	and	CC
cord-022353-q2k2krnm	296	12	receptor	receptor	NN
cord-022353-q2k2krnm	296	13	regulating	regulate	VBG
cord-022353-q2k2krnm	296	14	glucose	glucose	NN
cord-022353-q2k2krnm	296	15	metabolism	metabolism	NN
cord-022353-q2k2krnm	296	16	and	and	CC
cord-022353-q2k2krnm	296	17	,	,	,
cord-022353-q2k2krnm	296	18	depending	depend	VBG
cord-022353-q2k2krnm	296	19	on	on	IN
cord-022353-q2k2krnm	296	20	the	the	DT
cord-022353-q2k2krnm	296	21	gene	gene	NN
cord-022353-q2k2krnm	296	22	mutation	mutation	NN
cord-022353-q2k2krnm	296	23	,	,	,
cord-022353-q2k2krnm	296	24	may	may	MD
cord-022353-q2k2krnm	296	25	exhibit	exhibit	VB
cord-022353-q2k2krnm	296	26	altered	altered	JJ
cord-022353-q2k2krnm	296	27	levels	level	NNS
cord-022353-q2k2krnm	296	28	of	of	IN
cord-022353-q2k2krnm	296	29	plasma	plasma	NN
cord-022353-q2k2krnm	296	30	glucose	glucose	NN
cord-022353-q2k2krnm	296	31	.	.	.
cord-022353-q2k2krnm	297	1	For	for	IN
cord-022353-q2k2krnm	297	2	example	example	NN
cord-022353-q2k2krnm	297	3	,	,	,
cord-022353-q2k2krnm	297	4	adenosine	adenosine	NN
cord-022353-q2k2krnm	297	5	monophosphate	monophosphate	NN
cord-022353-q2k2krnm	297	6	-	-	HYPH
cord-022353-q2k2krnm	297	7	activated	activate	VBN
cord-022353-q2k2krnm	297	8	protein	protein	NN
cord-022353-q2k2krnm	297	9	kinase	kinase	NN
cord-022353-q2k2krnm	297	10	(	(	-LRB-
cord-022353-q2k2krnm	297	11	AMPK	AMPK	NNP
cord-022353-q2k2krnm	297	12	)	)	-RRB-
cord-022353-q2k2krnm	297	13	is	be	VBZ
cord-022353-q2k2krnm	297	14	a	a	DT
cord-022353-q2k2krnm	297	15	critical	critical	JJ
cord-022353-q2k2krnm	297	16	enzyme	enzyme	NN
cord-022353-q2k2krnm	297	17	in	in	IN
cord-022353-q2k2krnm	297	18	energy	energy	NN
cord-022353-q2k2krnm	297	19	metabolism	metabolism	NN
cord-022353-q2k2krnm	297	20	(	(	-LRB-
cord-022353-q2k2krnm	297	21	including	include	VBG
cord-022353-q2k2krnm	297	22	cellular	cellular	JJ
cord-022353-q2k2krnm	297	23	glucose	glucose	NN
cord-022353-q2k2krnm	297	24	uptake	uptake	NN
cord-022353-q2k2krnm	297	25	and	and	CC
cord-022353-q2k2krnm	297	26	fatty	fatty	JJ
cord-022353-q2k2krnm	297	27	acid	acid	NN
cord-022353-q2k2krnm	297	28	oxidation	oxidation	NN
cord-022353-q2k2krnm	297	29	in	in	IN
cord-022353-q2k2krnm	297	30	muscle	muscle	NN
cord-022353-q2k2krnm	297	31	,	,	,
cord-022353-q2k2krnm	297	32	and	and	CC
cord-022353-q2k2krnm	297	33	fatty	fatty	JJ
cord-022353-q2k2krnm	297	34	acid	acid	NN
cord-022353-q2k2krnm	297	35	synthesis	synthesis	NN
cord-022353-q2k2krnm	297	36	and	and	CC
cord-022353-q2k2krnm	297	37	gluconeogenesis	gluconeogenesis	NN
cord-022353-q2k2krnm	297	38	in	in	IN
cord-022353-q2k2krnm	297	39	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	297	40	)	)	-RRB-
cord-022353-q2k2krnm	297	41	.	.	.
cord-022353-q2k2krnm	298	1	Using	use	VBG
cord-022353-q2k2krnm	298	2	KO	KO	NNP
cord-022353-q2k2krnm	298	3	mice	mouse	NNS
cord-022353-q2k2krnm	298	4	,	,	,
cord-022353-q2k2krnm	298	5	Shaw	Shaw	NNP
cord-022353-q2k2krnm	298	6	et	et	NNP
cord-022353-q2k2krnm	298	7	al	al	NNP
cord-022353-q2k2krnm	298	8	.	.	.
cord-022353-q2k2krnm	299	1	(	(	-LRB-
cord-022353-q2k2krnm	299	2	2005	2005	CD
cord-022353-q2k2krnm	299	3	)	)	-RRB-
cord-022353-q2k2krnm	299	4	demonstrated	demonstrate	VBD
cord-022353-q2k2krnm	299	5	that	that	IN
cord-022353-q2k2krnm	299	6	kinase	kinase	NN
cord-022353-q2k2krnm	299	7	LKB	LKB	NNP
cord-022353-q2k2krnm	299	8	1	1	CD
cord-022353-q2k2krnm	299	9	is	be	VBZ
cord-022353-q2k2krnm	299	10	an	an	DT
cord-022353-q2k2krnm	299	11	important	important	JJ
cord-022353-q2k2krnm	299	12	activator	activator	NN
cord-022353-q2k2krnm	299	13	of	of	IN
cord-022353-q2k2krnm	299	14	AMPK	AMPK	NNP
cord-022353-q2k2krnm	299	15	in	in	IN
cord-022353-q2k2krnm	299	16	the	the	DT
cord-022353-q2k2krnm	299	17	liver	liver	NN
cord-022353-q2k2krnm	299	18	under	under	IN
cord-022353-q2k2krnm	299	19	energy	energy	NN
cord-022353-q2k2krnm	299	20	-	-	HYPH
cord-022353-q2k2krnm	299	21	stress	stress	NN
cord-022353-q2k2krnm	299	22	conditions	condition	NNS
cord-022353-q2k2krnm	299	23	,	,	,
cord-022353-q2k2krnm	299	24	and	and	CC
cord-022353-q2k2krnm	299	25	that	that	IN
cord-022353-q2k2krnm	299	26	KO	KO	NNP
cord-022353-q2k2krnm	299	27	mice	mouse	NNS
cord-022353-q2k2krnm	299	28	deficient	deficient	JJ
cord-022353-q2k2krnm	299	29	in	in	IN
cord-022353-q2k2krnm	299	30	kinase	kinase	NN
cord-022353-q2k2krnm	299	31	LKB1	LKB1	NNP
cord-022353-q2k2krnm	299	32	were	be	VBD
cord-022353-q2k2krnm	299	33	persistently	persistently	RB
cord-022353-q2k2krnm	299	34	hyperglycemic	hyperglycemic	JJ
cord-022353-q2k2krnm	299	35	.	.	.
cord-022353-q2k2krnm	300	1	The	the	DT
cord-022353-q2k2krnm	300	2	authors	author	NNS
cord-022353-q2k2krnm	300	3	also	also	RB
cord-022353-q2k2krnm	300	4	demonstrated	demonstrate	VBD
cord-022353-q2k2krnm	300	5	that	that	IN
cord-022353-q2k2krnm	300	6	kinase	kinase	NN
cord-022353-q2k2krnm	300	7	LKB	LKB	NNP
cord-022353-q2k2krnm	300	8	1	1	CD
cord-022353-q2k2krnm	300	9	is	be	VBZ
cord-022353-q2k2krnm	300	10	the	the	DT
cord-022353-q2k2krnm	300	11	target	target	NN
cord-022353-q2k2krnm	300	12	of	of	IN
cord-022353-q2k2krnm	300	13	the	the	DT
cord-022353-q2k2krnm	300	14	type	type	NN
cord-022353-q2k2krnm	300	15	2	2	CD
cord-022353-q2k2krnm	300	16	diabetic	diabetic	JJ
cord-022353-q2k2krnm	300	17	therapeutic	therapeutic	JJ
cord-022353-q2k2krnm	300	18	drug	drug	NN
cord-022353-q2k2krnm	300	19	,	,	,
cord-022353-q2k2krnm	300	20	metformin	metformin	NNP
cord-022353-q2k2krnm	300	21	.	.	.
cord-022353-q2k2krnm	301	1	Glucose	glucose	NN
cord-022353-q2k2krnm	301	2	tolerance	tolerance	NN
cord-022353-q2k2krnm	301	3	tests	test	NNS
cord-022353-q2k2krnm	301	4	(	(	-LRB-
cord-022353-q2k2krnm	301	5	GTT	GTT	NNP
cord-022353-q2k2krnm	301	6	)	)	-RRB-
cord-022353-q2k2krnm	301	7	have	have	VBP
cord-022353-q2k2krnm	301	8	been	be	VBN
cord-022353-q2k2krnm	301	9	performed	perform	VBN
cord-022353-q2k2krnm	301	10	in	in	IN
cord-022353-q2k2krnm	301	11	mice	mouse	NNS
cord-022353-q2k2krnm	301	12	.	.	.
cord-022353-q2k2krnm	302	1	One-	One-	NNP
cord-022353-q2k2krnm	302	2	,	,	,
cord-022353-q2k2krnm	303	1	3-	3-	LS
cord-022353-q2k2krnm	303	2	,	,	,
cord-022353-q2k2krnm	304	1	and	and	CC
cord-022353-q2k2krnm	304	2	4-h	4-h	CD
cord-022353-q2k2krnm	304	3	tests	test	NNS
cord-022353-q2k2krnm	304	4	have	have	VBP
cord-022353-q2k2krnm	304	5	been	be	VBN
cord-022353-q2k2krnm	304	6	conducted	conduct	VBN
cord-022353-q2k2krnm	304	7	.	.	.
cord-022353-q2k2krnm	305	1	In	in	IN
cord-022353-q2k2krnm	305	2	the	the	DT
cord-022353-q2k2krnm	305	3	1-h	1-h	CD
cord-022353-q2k2krnm	305	4	test	test	NN
cord-022353-q2k2krnm	305	5	,	,	,
cord-022353-q2k2krnm	305	6	glucose	glucose	NN
cord-022353-q2k2krnm	305	7	concentrations	concentration	NNS
cord-022353-q2k2krnm	305	8	are	be	VBP
cord-022353-q2k2krnm	305	9	evaluated	evaluate	VBN
cord-022353-q2k2krnm	305	10	before	before	IN
cord-022353-q2k2krnm	305	11	and	and	CC
cord-022353-q2k2krnm	305	12	1	1	CD
cord-022353-q2k2krnm	305	13	h	h	NN
cord-022353-q2k2krnm	305	14	following	follow	VBG
cord-022353-q2k2krnm	305	15	the	the	DT
cord-022353-q2k2krnm	305	16	administration	administration	NN
cord-022353-q2k2krnm	305	17	of	of	IN
cord-022353-q2k2krnm	305	18	2	2	CD
cord-022353-q2k2krnm	305	19	mg	mg	NNP
cord-022353-q2k2krnm	305	20	/	/	SYM
cord-022353-q2k2krnm	305	21	g	g	NN
cord-022353-q2k2krnm	305	22	glucose	glucose	NN
cord-022353-q2k2krnm	305	23	administered	administer	VBD
cord-022353-q2k2krnm	305	24	intraperitoneally	intraperitoneally	RB
cord-022353-q2k2krnm	305	25	(	(	-LRB-
cord-022353-q2k2krnm	305	26	IP	ip	NN
cord-022353-q2k2krnm	305	27	)	)	-RRB-
cord-022353-q2k2krnm	306	1	(	(	-LRB-
cord-022353-q2k2krnm	306	2	Oldstone	Oldstone	NNP
cord-022353-q2k2krnm	306	3	et	et	NNP
cord-022353-q2k2krnm	306	4	al	al	NNP
cord-022353-q2k2krnm	306	5	.	.	.
cord-022353-q2k2krnm	306	6	1984	1984	CD
cord-022353-q2k2krnm	306	7	)	)	-RRB-
cord-022353-q2k2krnm	306	8	.	.	.
cord-022353-q2k2krnm	307	1	The	the	DT
cord-022353-q2k2krnm	307	2	3-h	3-h	CD
cord-022353-q2k2krnm	307	3	test	test	NN
cord-022353-q2k2krnm	307	4	compares	compare	VBZ
cord-022353-q2k2krnm	307	5	pre	pre	JJ
cord-022353-q2k2krnm	307	6	-	-	JJ
cord-022353-q2k2krnm	307	7	injection	injection	JJ
cord-022353-q2k2krnm	307	8	serum	serum	NN
cord-022353-q2k2krnm	307	9	to	to	IN
cord-022353-q2k2krnm	307	10	serum	serum	NN
cord-022353-q2k2krnm	307	11	collected	collect	VBN
cord-022353-q2k2krnm	307	12	at	at	IN
cord-022353-q2k2krnm	307	13	15	15	CD
cord-022353-q2k2krnm	307	14	,	,	,
cord-022353-q2k2krnm	307	15	30	30	CD
cord-022353-q2k2krnm	307	16	,	,	,
cord-022353-q2k2krnm	307	17	60	60	CD
cord-022353-q2k2krnm	307	18	,	,	,
cord-022353-q2k2krnm	307	19	and	and	CC
cord-022353-q2k2krnm	307	20	120	120	CD
cord-022353-q2k2krnm	307	21	minutes	minute	NNS
cord-022353-q2k2krnm	307	22	following	follow	VBG
cord-022353-q2k2krnm	307	23	administration	administration	NN
cord-022353-q2k2krnm	307	24	of	of	IN
cord-022353-q2k2krnm	307	25	3	3	CD
cord-022353-q2k2krnm	307	26	mg	mg	NNP
cord-022353-q2k2krnm	307	27	/	/	SYM
cord-022353-q2k2krnm	307	28	g	g	NN
cord-022353-q2k2krnm	307	29	glucose	glucose	NN
cord-022353-q2k2krnm	307	30	given	give	VBN
cord-022353-q2k2krnm	307	31	IP	ip	NN
cord-022353-q2k2krnm	307	32	(	(	-LRB-
cord-022353-q2k2krnm	307	33	Hotamisligil	Hotamisligil	NNP
cord-022353-q2k2krnm	307	34	et	et	NNP
cord-022353-q2k2krnm	307	35	al	al	NNP
cord-022353-q2k2krnm	307	36	.	.	.
cord-022353-q2k2krnm	307	37	1996	1996	CD
cord-022353-q2k2krnm	307	38	)	)	-RRB-
cord-022353-q2k2krnm	307	39	.	.	.
cord-022353-q2k2krnm	308	1	A	a	DT
cord-022353-q2k2krnm	308	2	sensitive	sensitive	JJ
cord-022353-q2k2krnm	308	3	4-h	4-h	CD
cord-022353-q2k2krnm	308	4	GTT	GTT	NNP
cord-022353-q2k2krnm	308	5	has	have	VBZ
cord-022353-q2k2krnm	308	6	also	also	RB
cord-022353-q2k2krnm	308	7	been	be	VBN
cord-022353-q2k2krnm	308	8	described	describe	VBN
cord-022353-q2k2krnm	308	9	in	in	IN
cord-022353-q2k2krnm	308	10	which	which	WDT
cord-022353-q2k2krnm	308	11	mice	mouse	NNS
cord-022353-q2k2krnm	308	12	are	be	VBP
cord-022353-q2k2krnm	308	13	given	give	VBN
cord-022353-q2k2krnm	308	14	10	10	CD
cord-022353-q2k2krnm	308	15	ml	ml	NNS
cord-022353-q2k2krnm	308	16	/	/	SYM
cord-022353-q2k2krnm	308	17	kg	kg	NNS
cord-022353-q2k2krnm	308	18	of	of	IN
cord-022353-q2k2krnm	308	19	10	10	CD
cord-022353-q2k2krnm	308	20	%	%	NN
cord-022353-q2k2krnm	308	21	glucose	glucose	NN
cord-022353-q2k2krnm	308	22	orally	orally	RB
cord-022353-q2k2krnm	308	23	(	(	-LRB-
cord-022353-q2k2krnm	308	24	Gates	Gates	NNP
cord-022353-q2k2krnm	308	25	et	et	NNP
cord-022353-q2k2krnm	308	26	al	al	NNP
cord-022353-q2k2krnm	308	27	.	.	.
cord-022353-q2k2krnm	308	28	1972	1972	CD
cord-022353-q2k2krnm	308	29	)	)	-RRB-
cord-022353-q2k2krnm	308	30	.	.	.
cord-022353-q2k2krnm	309	1	The	the	DT
cord-022353-q2k2krnm	309	2	hypoglycemic	hypoglycemic	JJ
cord-022353-q2k2krnm	309	3	response	response	NN
cord-022353-q2k2krnm	309	4	to	to	IN
cord-022353-q2k2krnm	309	5	insulin	insulin	NN
cord-022353-q2k2krnm	309	6	in	in	IN
cord-022353-q2k2krnm	309	7	mice	mouse	NNS
cord-022353-q2k2krnm	309	8	has	have	VBZ
cord-022353-q2k2krnm	309	9	also	also	RB
cord-022353-q2k2krnm	309	10	been	be	VBN
cord-022353-q2k2krnm	309	11	described	describe	VBN
cord-022353-q2k2krnm	309	12	(	(	-LRB-
cord-022353-q2k2krnm	309	13	Hotamisligil	Hotamisligil	NNP
cord-022353-q2k2krnm	309	14	et	et	NNP
cord-022353-q2k2krnm	309	15	al	al	NNP
cord-022353-q2k2krnm	309	16	.	.	.
cord-022353-q2k2krnm	309	17	1996	1996	CD
cord-022353-q2k2krnm	309	18	)	)	-RRB-
cord-022353-q2k2krnm	309	19	.	.	.
cord-022353-q2k2krnm	310	1	Kaku	Kaku	NNP
cord-022353-q2k2krnm	310	2	et	et	NNP
cord-022353-q2k2krnm	310	3	al	al	NNP
cord-022353-q2k2krnm	310	4	.	.	.
cord-022353-q2k2krnm	311	1	(	(	-LRB-
cord-022353-q2k2krnm	311	2	1988	1988	CD
cord-022353-q2k2krnm	311	3	)	)	-RRB-
cord-022353-q2k2krnm	311	4	measured	measure	VBD
cord-022353-q2k2krnm	311	5	glucose	glucose	NN
cord-022353-q2k2krnm	311	6	,	,	,
cord-022353-q2k2krnm	311	7	glycosylated	glycosylated	JJ
cord-022353-q2k2krnm	311	8	hemoglobin	hemoglobin	NN
cord-022353-q2k2krnm	311	9	and	and	CC
cord-022353-q2k2krnm	311	10	insulin	insulin	NN
cord-022353-q2k2krnm	311	11	levels	level	NNS
cord-022353-q2k2krnm	311	12	in	in	IN
cord-022353-q2k2krnm	311	13	six	six	CD
cord-022353-q2k2krnm	311	14	inbred	inbred	JJ
cord-022353-q2k2krnm	311	15	strains	strain	NNS
cord-022353-q2k2krnm	311	16	undergoing	undergo	VBG
cord-022353-q2k2krnm	311	17	GTT	GTT	NNP
cord-022353-q2k2krnm	311	18	(	(	-LRB-
cord-022353-q2k2krnm	311	19	either	either	CC
cord-022353-q2k2krnm	311	20	in	in	IN
cord-022353-q2k2krnm	311	21	fed	fed	NNP
cord-022353-q2k2krnm	311	22	or	or	CC
cord-022353-q2k2krnm	311	23	fasted	fast	VBD
cord-022353-q2k2krnm	311	24	mice	mouse	NNS
cord-022353-q2k2krnm	311	25	)	)	-RRB-
cord-022353-q2k2krnm	311	26	.	.	.
cord-022353-q2k2krnm	312	1	To	to	TO
cord-022353-q2k2krnm	312	2	estimate	estimate	VB
cord-022353-q2k2krnm	312	3	the	the	DT
cord-022353-q2k2krnm	312	4	number	number	NN
cord-022353-q2k2krnm	312	5	of	of	IN
cord-022353-q2k2krnm	312	6	genes	gene	NNS
cord-022353-q2k2krnm	312	7	involved	involve	VBN
cord-022353-q2k2krnm	312	8	in	in	IN
cord-022353-q2k2krnm	312	9	phenotypic	phenotypic	JJ
cord-022353-q2k2krnm	312	10	differences	difference	NNS
cord-022353-q2k2krnm	312	11	in	in	IN
cord-022353-q2k2krnm	312	12	glucose	glucose	NN
cord-022353-q2k2krnm	312	13	tolerance	tolerance	NN
cord-022353-q2k2krnm	312	14	,	,	,
cord-022353-q2k2krnm	312	15	the	the	DT
cord-022353-q2k2krnm	312	16	least	least	RBS
cord-022353-q2k2krnm	312	17	glucose	glucose	NN
cord-022353-q2k2krnm	312	18	tolerant	tolerant	JJ
cord-022353-q2k2krnm	312	19	strain	strain	NN
cord-022353-q2k2krnm	312	20	(	(	-LRB-
cord-022353-q2k2krnm	312	21	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	312	22	)	)	-RRB-
cord-022353-q2k2krnm	312	23	was	be	VBD
cord-022353-q2k2krnm	312	24	bred	breed	VBN
cord-022353-q2k2krnm	312	25	to	to	IN
cord-022353-q2k2krnm	312	26	the	the	DT
cord-022353-q2k2krnm	312	27	most	most	RBS
cord-022353-q2k2krnm	312	28	tolerant	tolerant	JJ
cord-022353-q2k2krnm	312	29	strain	strain	NN
cord-022353-q2k2krnm	312	30	(	(	-LRB-
cord-022353-q2k2krnm	312	31	C3H	C3H	NNP
cord-022353-q2k2krnm	312	32	/	/	SYM
cord-022353-q2k2krnm	312	33	HeJ	HeJ	NNP
cord-022353-q2k2krnm	312	34	)	)	-RRB-
cord-022353-q2k2krnm	312	35	and	and	CC
cord-022353-q2k2krnm	312	36	F1	f1	NN
cord-022353-q2k2krnm	312	37	hybrids	hybrid	NNS
cord-022353-q2k2krnm	312	38	and	and	CC
cord-022353-q2k2krnm	312	39	backcross	backcross	JJ
cord-022353-q2k2krnm	312	40	animals	animal	NNS
cord-022353-q2k2krnm	312	41	tested	test	VBN
cord-022353-q2k2krnm	312	42	.	.	.
cord-022353-q2k2krnm	313	1	The	the	DT
cord-022353-q2k2krnm	313	2	authors	author	NNS
cord-022353-q2k2krnm	313	3	concluded	conclude	VBD
cord-022353-q2k2krnm	313	4	that	that	IN
cord-022353-q2k2krnm	313	5	glucose	glucose	NN
cord-022353-q2k2krnm	313	6	tolerance	tolerance	NN
cord-022353-q2k2krnm	313	7	in	in	IN
cord-022353-q2k2krnm	313	8	six	six	CD
cord-022353-q2k2krnm	313	9	commonly	commonly	RB
cord-022353-q2k2krnm	313	10	used	use	VBN
cord-022353-q2k2krnm	313	11	inbred	inbred	JJ
cord-022353-q2k2krnm	313	12	strains	strain	NNS
cord-022353-q2k2krnm	313	13	is	be	VBZ
cord-022353-q2k2krnm	313	14	a	a	DT
cord-022353-q2k2krnm	313	15	polygenic	polygenic	JJ
cord-022353-q2k2krnm	313	16	trait	trait	NN
cord-022353-q2k2krnm	313	17	.	.	.
cord-022353-q2k2krnm	314	1	Thrifty	thrifty	JJ
cord-022353-q2k2krnm	314	2	genes	gene	NNS
cord-022353-q2k2krnm	314	3	have	have	VBP
cord-022353-q2k2krnm	314	4	been	be	VBN
cord-022353-q2k2krnm	314	5	hypothesized	hypothesize	VBN
cord-022353-q2k2krnm	314	6	to	to	TO
cord-022353-q2k2krnm	314	7	give	give	VB
cord-022353-q2k2krnm	314	8	early	early	JJ
cord-022353-q2k2krnm	314	9	human	human	JJ
cord-022353-q2k2krnm	314	10	hunter	hunter	NN
cord-022353-q2k2krnm	314	11	-	-	HYPH
cord-022353-q2k2krnm	314	12	gatherers	gatherer	NNS
cord-022353-q2k2krnm	314	13	a	a	DT
cord-022353-q2k2krnm	314	14	survival	survival	NN
cord-022353-q2k2krnm	314	15	advantage	advantage	NN
cord-022353-q2k2krnm	314	16	by	by	IN
cord-022353-q2k2krnm	314	17	providing	provide	VBG
cord-022353-q2k2krnm	314	18	an	an	DT
cord-022353-q2k2krnm	314	19	economic	economic	JJ
cord-022353-q2k2krnm	314	20	mechanism	mechanism	NN
cord-022353-q2k2krnm	314	21	to	to	TO
cord-022353-q2k2krnm	314	22	store	store	VB
cord-022353-q2k2krnm	314	23	energy	energy	NN
cord-022353-q2k2krnm	314	24	during	during	IN
cord-022353-q2k2krnm	314	25	periods	period	NNS
cord-022353-q2k2krnm	314	26	of	of	IN
cord-022353-q2k2krnm	314	27	famine	famine	NN
cord-022353-q2k2krnm	314	28	(	(	-LRB-
cord-022353-q2k2krnm	314	29	Zimmet	Zimmet	NNP
cord-022353-q2k2krnm	314	30	and	and	CC
cord-022353-q2k2krnm	314	31	Thomas	Thomas	NNP
cord-022353-q2k2krnm	314	32	2003	2003	CD
cord-022353-q2k2krnm	314	33	)	)	-RRB-
cord-022353-q2k2krnm	314	34	.	.	.
cord-022353-q2k2krnm	315	1	Because	because	IN
cord-022353-q2k2krnm	315	2	the	the	DT
cord-022353-q2k2krnm	315	3	most	most	RBS
cord-022353-q2k2krnm	315	4	efficient	efficient	JJ
cord-022353-q2k2krnm	315	5	mechanism	mechanism	NN
cord-022353-q2k2krnm	315	6	for	for	IN
cord-022353-q2k2krnm	315	7	energy	energy	NN
cord-022353-q2k2krnm	315	8	storage	storage	NN
cord-022353-q2k2krnm	315	9	is	be	VBZ
cord-022353-q2k2krnm	315	10	through	through	IN
cord-022353-q2k2krnm	315	11	promotion	promotion	NN
cord-022353-q2k2krnm	315	12	of	of	IN
cord-022353-q2k2krnm	315	13	adipose	adipose	JJ
cord-022353-q2k2krnm	315	14	tissue	tissue	NN
cord-022353-q2k2krnm	315	15	,	,	,
cord-022353-q2k2krnm	315	16	it	-PRON-	PRP
cord-022353-q2k2krnm	315	17	seems	seem	VBZ
cord-022353-q2k2krnm	315	18	reasonable	reasonable	JJ
cord-022353-q2k2krnm	315	19	that	that	IN
cord-022353-q2k2krnm	315	20	at	at	IN
cord-022353-q2k2krnm	315	21	least	least	JJS
cord-022353-q2k2krnm	315	22	some	some	DT
cord-022353-q2k2krnm	315	23	of	of	IN
cord-022353-q2k2krnm	315	24	these	these	DT
cord-022353-q2k2krnm	315	25	"	"	``
cord-022353-q2k2krnm	315	26	thrifty	thrifty	JJ
cord-022353-q2k2krnm	315	27	"	"	''
cord-022353-q2k2krnm	315	28	genes	gene	NNS
cord-022353-q2k2krnm	315	29	may	may	MD
cord-022353-q2k2krnm	315	30	function	function	VB
cord-022353-q2k2krnm	315	31	in	in	IN
cord-022353-q2k2krnm	315	32	this	this	DT
cord-022353-q2k2krnm	315	33	manner	manner	NN
cord-022353-q2k2krnm	315	34	.	.	.
cord-022353-q2k2krnm	316	1	Another	another	DT
cord-022353-q2k2krnm	316	2	hypothesis	hypothesis	NN
cord-022353-q2k2krnm	316	3	holds	hold	VBZ
cord-022353-q2k2krnm	316	4	that	that	IN
cord-022353-q2k2krnm	316	5	during	during	IN
cord-022353-q2k2krnm	316	6	periods	period	NNS
cord-022353-q2k2krnm	316	7	of	of	IN
cord-022353-q2k2krnm	316	8	famine	famine	NN
cord-022353-q2k2krnm	316	9	it	-PRON-	PRP
cord-022353-q2k2krnm	316	10	is	be	VBZ
cord-022353-q2k2krnm	316	11	essential	essential	JJ
cord-022353-q2k2krnm	316	12	to	to	TO
cord-022353-q2k2krnm	316	13	conserve	conserve	VB
cord-022353-q2k2krnm	316	14	glucose	glucose	NN
cord-022353-q2k2krnm	316	15	for	for	IN
cord-022353-q2k2krnm	316	16	use	use	NN
cord-022353-q2k2krnm	316	17	by	by	IN
cord-022353-q2k2krnm	316	18	the	the	DT
cord-022353-q2k2krnm	316	19	brain	brain	NN
cord-022353-q2k2krnm	316	20	and	and	CC
cord-022353-q2k2krnm	316	21	that	that	IN
cord-022353-q2k2krnm	316	22	the	the	DT
cord-022353-q2k2krnm	316	23	mechanism	mechanism	NN
cord-022353-q2k2krnm	316	24	responsible	responsible	JJ
cord-022353-q2k2krnm	316	25	involves	involve	VBZ
cord-022353-q2k2krnm	316	26	insulin	insulin	NN
cord-022353-q2k2krnm	316	27	resistance	resistance	NN
cord-022353-q2k2krnm	316	28	in	in	IN
cord-022353-q2k2krnm	316	29	peripheral	peripheral	JJ
cord-022353-q2k2krnm	316	30	tissues	tissue	NNS
cord-022353-q2k2krnm	316	31	(	(	-LRB-
cord-022353-q2k2krnm	316	32	Neel	Neel	NNP
cord-022353-q2k2krnm	316	33	1962	1962	CD
cord-022353-q2k2krnm	316	34	)	)	-RRB-
cord-022353-q2k2krnm	316	35	.	.	.
cord-022353-q2k2krnm	317	1	Should	Should	MD
cord-022353-q2k2krnm	317	2	both	both	DT
cord-022353-q2k2krnm	317	3	hypotheses	hypothesis	NNS
cord-022353-q2k2krnm	317	4	be	be	VB
cord-022353-q2k2krnm	317	5	true	true	JJ
cord-022353-q2k2krnm	317	6	it	-PRON-	PRP
cord-022353-q2k2krnm	317	7	is	be	VBZ
cord-022353-q2k2krnm	317	8	easy	easy	JJ
cord-022353-q2k2krnm	317	9	to	to	TO
cord-022353-q2k2krnm	317	10	envision	envision	VB
cord-022353-q2k2krnm	317	11	an	an	DT
cord-022353-q2k2krnm	317	12	association	association	NN
cord-022353-q2k2krnm	317	13	between	between	IN
cord-022353-q2k2krnm	317	14	obesity	obesity	NN
cord-022353-q2k2krnm	317	15	and	and	CC
cord-022353-q2k2krnm	317	16	type	type	NN
cord-022353-q2k2krnm	317	17	2	2	CD
cord-022353-q2k2krnm	317	18	diabetes	diabete	NNS
cord-022353-q2k2krnm	317	19	,	,	,
cord-022353-q2k2krnm	317	20	especially	especially	RB
cord-022353-q2k2krnm	317	21	where	where	WRB
cord-022353-q2k2krnm	317	22	sedentary	sedentary	JJ
cord-022353-q2k2krnm	317	23	lifestyle	lifestyle	NN
cord-022353-q2k2krnm	317	24	and	and	CC
cord-022353-q2k2krnm	317	25	unrestricted	unrestricted	JJ
cord-022353-q2k2krnm	317	26	access	access	NN
cord-022353-q2k2krnm	317	27	to	to	IN
cord-022353-q2k2krnm	317	28	food	food	NN
cord-022353-q2k2krnm	317	29	occur	occur	VBP
cord-022353-q2k2krnm	317	30	together	together	RB
cord-022353-q2k2krnm	317	31	(	(	-LRB-
cord-022353-q2k2krnm	317	32	Lazar	Lazar	NNP
cord-022353-q2k2krnm	317	33	2005	2005	CD
cord-022353-q2k2krnm	317	34	)	)	-RRB-
cord-022353-q2k2krnm	317	35	.	.	.
cord-022353-q2k2krnm	318	1	One	one	CD
cord-022353-q2k2krnm	318	2	candidate	candidate	NN
cord-022353-q2k2krnm	318	3	thrifty	thrifty	JJ
cord-022353-q2k2krnm	318	4	gene	gene	NN
cord-022353-q2k2krnm	318	5	encodes	encode	VBZ
cord-022353-q2k2krnm	318	6	the	the	DT
cord-022353-q2k2krnm	318	7	hormone	hormone	NN
cord-022353-q2k2krnm	318	8	leptin	leptin	NN
cord-022353-q2k2krnm	318	9	.	.	.
cord-022353-q2k2krnm	319	1	Leptin	leptin	NN
cord-022353-q2k2krnm	319	2	is	be	VBZ
cord-022353-q2k2krnm	319	3	produced	produce	VBN
cord-022353-q2k2krnm	319	4	by	by	IN
cord-022353-q2k2krnm	319	5	adipose	adipose	JJ
cord-022353-q2k2krnm	319	6	tissue	tissue	NN
cord-022353-q2k2krnm	319	7	,	,	,
cord-022353-q2k2krnm	319	8	and	and	CC
cord-022353-q2k2krnm	319	9	its	-PRON-	PRP$
cord-022353-q2k2krnm	319	10	absence	absence	NN
cord-022353-q2k2krnm	319	11	leads	lead	VBZ
cord-022353-q2k2krnm	319	12	to	to	IN
cord-022353-q2k2krnm	319	13	obesity	obesity	NN
cord-022353-q2k2krnm	319	14	and	and	CC
cord-022353-q2k2krnm	319	15	insulin	insulin	NN
cord-022353-q2k2krnm	319	16	resistance	resistance	NN
cord-022353-q2k2krnm	319	17	.	.	.
cord-022353-q2k2krnm	320	1	During	during	IN
cord-022353-q2k2krnm	320	2	times	time	NNS
cord-022353-q2k2krnm	320	3	of	of	IN
cord-022353-q2k2krnm	320	4	high	high	JJ
cord-022353-q2k2krnm	320	5	adipose	adipose	JJ
cord-022353-q2k2krnm	320	6	storage	storage	NN
cord-022353-q2k2krnm	320	7	blood	blood	NN
cord-022353-q2k2krnm	320	8	levels	level	NNS
cord-022353-q2k2krnm	320	9	of	of	IN
cord-022353-q2k2krnm	320	10	leptin	leptin	NN
cord-022353-q2k2krnm	320	11	are	be	VBP
cord-022353-q2k2krnm	320	12	high	high	JJ
cord-022353-q2k2krnm	320	13	and	and	CC
cord-022353-q2k2krnm	320	14	it	-PRON-	PRP
cord-022353-q2k2krnm	320	15	promotes	promote	VBZ
cord-022353-q2k2krnm	320	16	energy	energy	NN
cord-022353-q2k2krnm	320	17	metabolism	metabolism	NN
cord-022353-q2k2krnm	320	18	and	and	CC
cord-022353-q2k2krnm	320	19	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	320	20	food	food	NN
cord-022353-q2k2krnm	320	21	intake	intake	NN
cord-022353-q2k2krnm	320	22	.	.	.
cord-022353-q2k2krnm	321	1	The	the	DT
cord-022353-q2k2krnm	321	2	opposite	opposite	JJ
cord-022353-q2k2krnm	321	3	occurs	occur	VBZ
cord-022353-q2k2krnm	321	4	during	during	IN
cord-022353-q2k2krnm	321	5	starvation	starvation	NN
cord-022353-q2k2krnm	321	6	.	.	.
cord-022353-q2k2krnm	322	1	But	but	CC
cord-022353-q2k2krnm	322	2	leptin	leptin	NN
cord-022353-q2k2krnm	322	3	is	be	VBZ
cord-022353-q2k2krnm	322	4	only	only	RB
cord-022353-q2k2krnm	322	5	one	one	CD
cord-022353-q2k2krnm	322	6	of	of	IN
cord-022353-q2k2krnm	322	7	a	a	DT
cord-022353-q2k2krnm	322	8	number	number	NN
cord-022353-q2k2krnm	322	9	of	of	IN
cord-022353-q2k2krnm	322	10	adipokines	adipokine	NNS
cord-022353-q2k2krnm	322	11	,	,	,
cord-022353-q2k2krnm	322	12	secreted	secrete	VBN
cord-022353-q2k2krnm	322	13	by	by	IN
cord-022353-q2k2krnm	322	14	adipose	adipose	JJ
cord-022353-q2k2krnm	322	15	tissue	tissue	NN
cord-022353-q2k2krnm	322	16	,	,	,
cord-022353-q2k2krnm	322	17	which	which	WDT
cord-022353-q2k2krnm	322	18	aid	aid	NN
cord-022353-q2k2krnm	322	19	in	in	IN
cord-022353-q2k2krnm	322	20	the	the	DT
cord-022353-q2k2krnm	322	21	regulating	regulate	VBG
cord-022353-q2k2krnm	322	22	appetite	appetite	NN
cord-022353-q2k2krnm	322	23	and	and	CC
cord-022353-q2k2krnm	322	24	metabolism	metabolism	NN
cord-022353-q2k2krnm	322	25	.	.	.
cord-022353-q2k2krnm	323	1	In	in	IN
cord-022353-q2k2krnm	323	2	fact	fact	NN
cord-022353-q2k2krnm	323	3	the	the	DT
cord-022353-q2k2krnm	323	4	location	location	NN
cord-022353-q2k2krnm	323	5	of	of	IN
cord-022353-q2k2krnm	323	6	the	the	DT
cord-022353-q2k2krnm	323	7	adipose	adipose	JJ
cord-022353-q2k2krnm	323	8	tissue	tissue	NN
cord-022353-q2k2krnm	323	9	,	,	,
cord-022353-q2k2krnm	323	10	the	the	DT
cord-022353-q2k2krnm	323	11	size	size	NN
cord-022353-q2k2krnm	323	12	of	of	IN
cord-022353-q2k2krnm	323	13	average	average	JJ
cord-022353-q2k2krnm	323	14	adipocytes	adipocyte	NNS
cord-022353-q2k2krnm	323	15	,	,	,
cord-022353-q2k2krnm	323	16	and	and	CC
cord-022353-q2k2krnm	323	17	adipocyte	adipocyte	NN
cord-022353-q2k2krnm	323	18	metabolism	metabolism	NN
cord-022353-q2k2krnm	323	19	of	of	IN
cord-022353-q2k2krnm	323	20	glucose	glucose	NN
cord-022353-q2k2krnm	323	21	and	and	CC
cord-022353-q2k2krnm	323	22	corticosteroids	corticosteroid	NNS
cord-022353-q2k2krnm	323	23	each	each	DT
cord-022353-q2k2krnm	323	24	modify	modify	VBP
cord-022353-q2k2krnm	323	25	the	the	DT
cord-022353-q2k2krnm	323	26	endocrine	endocrine	JJ
cord-022353-q2k2krnm	323	27	function	function	NN
cord-022353-q2k2krnm	323	28	of	of	IN
cord-022353-q2k2krnm	323	29	adipose	adipose	JJ
cord-022353-q2k2krnm	323	30	tissue	tissue	NN
cord-022353-q2k2krnm	323	31	(	(	-LRB-
cord-022353-q2k2krnm	323	32	Lazar	Lazar	NNP
cord-022353-q2k2krnm	323	33	2005	2005	CD
cord-022353-q2k2krnm	323	34	)	)	-RRB-
cord-022353-q2k2krnm	323	35	.	.	.
cord-022353-q2k2krnm	324	1	Among	among	IN
cord-022353-q2k2krnm	324	2	the	the	DT
cord-022353-q2k2krnm	324	3	proteins	protein	NNS
cord-022353-q2k2krnm	324	4	secreted	secrete	VBN
cord-022353-q2k2krnm	324	5	by	by	IN
cord-022353-q2k2krnm	324	6	adipose	adipose	JJ
cord-022353-q2k2krnm	324	7	tissue	tissue	NN
cord-022353-q2k2krnm	324	8	are	be	VBP
cord-022353-q2k2krnm	324	9	adiponectin	adiponectin	NN
cord-022353-q2k2krnm	324	10	,	,	,
cord-022353-q2k2krnm	324	11	adipsin	adipsin	NNP
cord-022353-q2k2krnm	324	12	,	,	,
cord-022353-q2k2krnm	324	13	resistin	resistin	NNPS
cord-022353-q2k2krnm	324	14	,	,	,
cord-022353-q2k2krnm	324	15	visfatin	visfatin	NNP
cord-022353-q2k2krnm	324	16	,	,	,
cord-022353-q2k2krnm	324	17	tumor	tumor	NN
cord-022353-q2k2krnm	324	18	necrosis	necrosis	NN
cord-022353-q2k2krnm	324	19	factor	factor	NN
cord-022353-q2k2krnm	324	20	-	-	:
cord-022353-q2k2krnm	324	21	a	a	NN
cord-022353-q2k2krnm	325	1	(	(	-LRB-
cord-022353-q2k2krnm	325	2	TNF	TNF	NNP
cord-022353-q2k2krnm	325	3	-	-	HYPH
cord-022353-q2k2krnm	325	4	a	a	NNP
cord-022353-q2k2krnm	325	5	)	)	-RRB-
cord-022353-q2k2krnm	325	6	,	,	.
cord-022353-q2k2krnm	326	1	interleukin-6	interleukin-6	NNP
cord-022353-q2k2krnm	326	2	(	(	-LRB-
cord-022353-q2k2krnm	327	1	IL-6	IL-6	NNP
cord-022353-q2k2krnm	327	2	)	)	-RRB-
cord-022353-q2k2krnm	327	3	,	,	,
cord-022353-q2k2krnm	327	4	macrophage	macrophage	NN
cord-022353-q2k2krnm	327	5	chemoattractant	chemoattractant	NN
cord-022353-q2k2krnm	327	6	protein-1	protein-1	NNP
cord-022353-q2k2krnm	327	7	(	(	-LRB-
cord-022353-q2k2krnm	327	8	MCP-1	MCP-1	NNP
cord-022353-q2k2krnm	327	9	)	)	-RRB-
cord-022353-q2k2krnm	327	10	,	,	,
cord-022353-q2k2krnm	327	11	plasminogen	plasminogen	NN
cord-022353-q2k2krnm	327	12	activator	activator	NN
cord-022353-q2k2krnm	327	13	inhibitor-1	inhibitor-1	NNP
cord-022353-q2k2krnm	327	14	(	(	-LRB-
cord-022353-q2k2krnm	327	15	PAI-1	PAI-1	NNP
cord-022353-q2k2krnm	327	16	)	)	-RRB-
cord-022353-q2k2krnm	327	17	,	,	,
cord-022353-q2k2krnm	327	18	angiotensinogen	angiotensinogen	NNP
cord-022353-q2k2krnm	327	19	,	,	,
cord-022353-q2k2krnm	327	20	SAA	SAA	NNP
cord-022353-q2k2krnm	327	21	,	,	,
cord-022353-q2k2krnm	327	22	and	and	CC
cord-022353-q2k2krnm	327	23	a	a	DT
cord-022353-q2k2krnm	327	24	-	-	HYPH
cord-022353-q2k2krnm	327	25	acid	acid	NN
cord-022353-q2k2krnm	327	26	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	327	27	.	.	.
cord-022353-q2k2krnm	328	1	Like	like	IN
cord-022353-q2k2krnm	328	2	adipocyte	adipocyte	NN
cord-022353-q2k2krnm	328	3	-	-	HYPH
cord-022353-q2k2krnm	328	4	derived	derive	VBN
cord-022353-q2k2krnm	328	5	free	free	JJ
cord-022353-q2k2krnm	328	6	fatty	fatty	JJ
cord-022353-q2k2krnm	328	7	acids	acid	NNS
cord-022353-q2k2krnm	328	8	,	,	,
cord-022353-q2k2krnm	328	9	which	which	WDT
cord-022353-q2k2krnm	328	10	have	have	VBP
cord-022353-q2k2krnm	328	11	been	be	VBN
cord-022353-q2k2krnm	328	12	shown	show	VBN
cord-022353-q2k2krnm	328	13	to	to	TO
cord-022353-q2k2krnm	328	14	contribute	contribute	VB
cord-022353-q2k2krnm	328	15	to	to	IN
cord-022353-q2k2krnm	328	16	insulin	insulin	NN
cord-022353-q2k2krnm	328	17	resistance	resistance	NN
cord-022353-q2k2krnm	328	18	in	in	IN
cord-022353-q2k2krnm	328	19	liver	liver	NN
cord-022353-q2k2krnm	328	20	and	and	CC
cord-022353-q2k2krnm	328	21	muscle	muscle	NN
cord-022353-q2k2krnm	328	22	,	,	,
cord-022353-q2k2krnm	328	23	most	most	JJS
cord-022353-q2k2krnm	328	24	of	of	IN
cord-022353-q2k2krnm	328	25	these	these	DT
cord-022353-q2k2krnm	328	26	proteins	protein	NNS
cord-022353-q2k2krnm	328	27	are	be	VBP
cord-022353-q2k2krnm	328	28	capable	capable	JJ
cord-022353-q2k2krnm	328	29	of	of	IN
cord-022353-q2k2krnm	328	30	modulating	modulate	VBG
cord-022353-q2k2krnm	328	31	glucose	glucose	NN
cord-022353-q2k2krnm	328	32	metabolism	metabolism	NN
cord-022353-q2k2krnm	328	33	and	and	CC
cord-022353-q2k2krnm	328	34	insulin	insulin	NN
cord-022353-q2k2krnm	328	35	action	action	NN
cord-022353-q2k2krnm	328	36	.	.	.
cord-022353-q2k2krnm	329	1	Adiponectin	Adiponectin	NNP
cord-022353-q2k2krnm	329	2	and	and	CC
cord-022353-q2k2krnm	329	3	visfatin	visfatin	NN
cord-022353-q2k2krnm	329	4	work	work	NN
cord-022353-q2k2krnm	329	5	synergistically	synergistically	RB
cord-022353-q2k2krnm	329	6	with	with	IN
cord-022353-q2k2krnm	329	7	insulin	insulin	NN
cord-022353-q2k2krnm	329	8	to	to	TO
cord-022353-q2k2krnm	329	9	enhance	enhance	VB
cord-022353-q2k2krnm	329	10	glucose	glucose	NN
cord-022353-q2k2krnm	329	11	uptake	uptake	NN
cord-022353-q2k2krnm	329	12	by	by	IN
cord-022353-q2k2krnm	329	13	muscle	muscle	NN
cord-022353-q2k2krnm	329	14	and	and	CC
cord-022353-q2k2krnm	329	15	block	block	VB
cord-022353-q2k2krnm	329	16	glucose	glucose	NN
cord-022353-q2k2krnm	329	17	synthesis	synthesis	NN
cord-022353-q2k2krnm	329	18	by	by	IN
cord-022353-q2k2krnm	329	19	the	the	DT
cord-022353-q2k2krnm	329	20	liver	liver	NN
cord-022353-q2k2krnm	329	21	(	(	-LRB-
cord-022353-q2k2krnm	329	22	Hug	Hug	NNP
cord-022353-q2k2krnm	329	23	and	and	CC
cord-022353-q2k2krnm	329	24	Lodish	Lodish	NNP
cord-022353-q2k2krnm	329	25	2005	2005	CD
cord-022353-q2k2krnm	329	26	)	)	-RRB-
cord-022353-q2k2krnm	329	27	.	.	.
cord-022353-q2k2krnm	330	1	Blood	blood	NN
cord-022353-q2k2krnm	330	2	levels	level	NNS
cord-022353-q2k2krnm	330	3	of	of	IN
cord-022353-q2k2krnm	330	4	visfatin	visfatin	JJ
cord-022353-q2k2krnm	330	5	increase	increase	NN
cord-022353-q2k2krnm	330	6	in	in	IN
cord-022353-q2k2krnm	330	7	obesity	obesity	NN
cord-022353-q2k2krnm	330	8	and	and	CC
cord-022353-q2k2krnm	330	9	the	the	DT
cord-022353-q2k2krnm	330	10	cytokine	cytokine	NN
cord-022353-q2k2krnm	330	11	can	can	MD
cord-022353-q2k2krnm	330	12	bind	bind	VB
cord-022353-q2k2krnm	330	13	to	to	IN
cord-022353-q2k2krnm	330	14	and	and	CC
cord-022353-q2k2krnm	330	15	Stimulate	stimulate	VB
cord-022353-q2k2krnm	330	16	the	the	DT
cord-022353-q2k2krnm	330	17	insulin	insulin	NN
cord-022353-q2k2krnm	330	18	receptor	receptor	NN
cord-022353-q2k2krnm	330	19	(	(	-LRB-
cord-022353-q2k2krnm	330	20	Fukuhara	Fukuhara	NNP
cord-022353-q2k2krnm	330	21	et	et	FW
cord-022353-q2k2krnm	330	22	al	al	NNP
cord-022353-q2k2krnm	330	23	.	.	NNP
cord-022353-q2k2krnm	330	24	2005	2005	CD
cord-022353-q2k2krnm	330	25	)	)	-RRB-
cord-022353-q2k2krnm	330	26	.	.	.
cord-022353-q2k2krnm	331	1	Blood	blood	NN
cord-022353-q2k2krnm	331	2	levels	level	NNS
cord-022353-q2k2krnm	331	3	of	of	IN
cord-022353-q2k2krnm	331	4	adiponectin	adiponectin	NN
cord-022353-q2k2krnm	331	5	negatively	negatively	RB
cord-022353-q2k2krnm	331	6	correlate	correlate	VBP
cord-022353-q2k2krnm	331	7	with	with	IN
cord-022353-q2k2krnm	331	8	body	body	NN
cord-022353-q2k2krnm	331	9	mass	mass	NN
cord-022353-q2k2krnm	331	10	and	and	CC
cord-022353-q2k2krnm	331	11	are	be	VBP
cord-022353-q2k2krnm	331	12	lower	low	JJR
cord-022353-q2k2krnm	331	13	in	in	IN
cord-022353-q2k2krnm	331	14	obese	obese	JJ
cord-022353-q2k2krnm	331	15	humans	human	NNS
cord-022353-q2k2krnm	331	16	and	and	CC
cord-022353-q2k2krnm	331	17	mice	mouse	NNS
cord-022353-q2k2krnm	331	18	,	,	,
cord-022353-q2k2krnm	331	19	suggesting	suggest	VBG
cord-022353-q2k2krnm	331	20	that	that	IN
cord-022353-q2k2krnm	331	21	reduced	reduce	VBN
cord-022353-q2k2krnm	331	22	mRNA	mrna	NN
cord-022353-q2k2krnm	331	23	expression	expression	NN
cord-022353-q2k2krnm	331	24	of	of	IN
cord-022353-q2k2krnm	331	25	the	the	DT
cord-022353-q2k2krnm	331	26	adiponectin	adiponectin	NN
cord-022353-q2k2krnm	331	27	gene	gene	NN
cord-022353-q2k2krnm	331	28	may	may	MD
cord-022353-q2k2krnm	331	29	be	be	VB
cord-022353-q2k2krnm	331	30	involved	involve	VBN
cord-022353-q2k2krnm	331	31	with	with	IN
cord-022353-q2k2krnm	331	32	obesity	obesity	NN
cord-022353-q2k2krnm	331	33	(	(	-LRB-
cord-022353-q2k2krnm	331	34	Masaki	Masaki	NNP
cord-022353-q2k2krnm	331	35	et	et	NNP
cord-022353-q2k2krnm	331	36	al	al	NNP
cord-022353-q2k2krnm	331	37	.	.	.
cord-022353-q2k2krnm	331	38	2004	2004	CD
cord-022353-q2k2krnm	331	39	)	)	-RRB-
cord-022353-q2k2krnm	331	40	.	.	.
cord-022353-q2k2krnm	332	1	Increases	increase	NNS
cord-022353-q2k2krnm	332	2	in	in	IN
cord-022353-q2k2krnm	332	3	adiponectin	adiponectin	NN
cord-022353-q2k2krnm	332	4	downregulate	downregulate	VBP
cord-022353-q2k2krnm	332	5	the	the	DT
cord-022353-q2k2krnm	332	6	hepatic	hepatic	JJ
cord-022353-q2k2krnm	332	7	expression	expression	NN
cord-022353-q2k2krnm	332	8	of	of	IN
cord-022353-q2k2krnm	332	9	TNF	TNF	NNP
cord-022353-q2k2krnm	332	10	-	-	HYPH
cord-022353-q2k2krnm	332	11	a	a	NNP
cord-022353-q2k2krnm	332	12	.	.	.
cord-022353-q2k2krnm	333	1	It	-PRON-	PRP
cord-022353-q2k2krnm	333	2	mediates	mediate	VBZ
cord-022353-q2k2krnm	333	3	its	-PRON-	PRP$
cord-022353-q2k2krnm	333	4	antidiabetogenic	antidiabetogenic	JJ
cord-022353-q2k2krnm	333	5	effects	effect	NNS
cord-022353-q2k2krnm	333	6	via	via	IN
cord-022353-q2k2krnm	333	7	receptors	receptor	NNS
cord-022353-q2k2krnm	333	8	on	on	IN
cord-022353-q2k2krnm	333	9	peripheral	peripheral	JJ
cord-022353-q2k2krnm	333	10	tissues	tissue	NNS
cord-022353-q2k2krnm	333	11	,	,	,
cord-022353-q2k2krnm	333	12	especially	especially	RB
cord-022353-q2k2krnm	333	13	liver	liver	NN
cord-022353-q2k2krnm	333	14	.	.	.
cord-022353-q2k2krnm	334	1	TNF	TNF	NNP
cord-022353-q2k2krnm	334	2	-	-	HYPH
cord-022353-q2k2krnm	334	3	a	a	NNP
cord-022353-q2k2krnm	334	4	,	,	,
cord-022353-q2k2krnm	334	5	resistin	resistin	NN
cord-022353-q2k2krnm	334	6	,	,	,
cord-022353-q2k2krnm	334	7	and	and	CC
cord-022353-q2k2krnm	334	8	IL-6	IL-6	NNP
cord-022353-q2k2krnm	334	9	each	each	DT
cord-022353-q2k2krnm	334	10	induce	induce	VBP
cord-022353-q2k2krnm	334	11	resistance	resistance	NN
cord-022353-q2k2krnm	334	12	to	to	IN
cord-022353-q2k2krnm	334	13	insulin	insulin	NN
cord-022353-q2k2krnm	334	14	.	.	.
cord-022353-q2k2krnm	335	1	However	however	RB
cord-022353-q2k2krnm	335	2	TNF	TNF	NNP
cord-022353-q2k2krnm	335	3	-	-	:
cord-022353-q2k2krnm	335	4	a	a	NNP
cord-022353-q2k2krnm	335	5	also	also	RB
cord-022353-q2k2krnm	335	6	suppresses	suppress	VBZ
cord-022353-q2k2krnm	335	7	expression	expression	NN
cord-022353-q2k2krnm	335	8	of	of	IN
cord-022353-q2k2krnm	335	9	adipocyte	adipocyte	JJ
cord-022353-q2k2krnm	335	10	specific	specific	JJ
cord-022353-q2k2krnm	335	11	FRED	FRED	NNP
cord-022353-q2k2krnm	335	12	W.	W.	NNP
cord-022353-q2k2krnm	335	13	QUIMBY	QUIMBY	NNP
cord-022353-q2k2krnm	335	14	AND	and	CC
cord-022353-q2k2krnm	335	15	RICHARD	RICHARD	NNP
cord-022353-q2k2krnm	335	16	H.	H.	NNP
cord-022353-q2k2krnm	335	17	LUONG	LUONG	NNP
cord-022353-q2k2krnm	335	18	t	t	NN
cord-022353-q2k2krnm	335	19	genes	gene	NNS
cord-022353-q2k2krnm	335	20	;	;	:
cord-022353-q2k2krnm	335	21	resistin	resistin	NNP
cord-022353-q2k2krnm	335	22	maintains	maintain	VBZ
cord-022353-q2k2krnm	335	23	glucose	glucose	NN
cord-022353-q2k2krnm	335	24	during	during	IN
cord-022353-q2k2krnm	335	25	fasting	fast	VBG
cord-022353-q2k2krnm	335	26	;	;	:
cord-022353-q2k2krnm	335	27	and	and	CC
cord-022353-q2k2krnm	335	28	IL-6	IL-6	NNP
cord-022353-q2k2krnm	335	29	production	production	NN
cord-022353-q2k2krnm	335	30	increases	increase	NNS
cord-022353-q2k2krnm	335	31	in	in	IN
cord-022353-q2k2krnm	335	32	the	the	DT
cord-022353-q2k2krnm	335	33	obese	obese	NN
cord-022353-q2k2krnm	335	34	.	.	.
cord-022353-q2k2krnm	336	1	The	the	DT
cord-022353-q2k2krnm	336	2	cytokines	cytokine	NNS
cord-022353-q2k2krnm	336	3	TNF-~	TNF-~	NNP
cord-022353-q2k2krnm	336	4	and	and	CC
cord-022353-q2k2krnm	336	5	IL-6	IL-6	NNP
cord-022353-q2k2krnm	336	6	are	be	VBP
cord-022353-q2k2krnm	336	7	proinflammatory	proinflammatory	JJ
cord-022353-q2k2krnm	336	8	,	,	,
cord-022353-q2k2krnm	336	9	are	be	VBP
cord-022353-q2k2krnm	336	10	also	also	RB
cord-022353-q2k2krnm	336	11	produced	produce	VBN
cord-022353-q2k2krnm	336	12	by	by	IN
cord-022353-q2k2krnm	336	13	monocytes	monocyte	NNS
cord-022353-q2k2krnm	336	14	,	,	,
cord-022353-q2k2krnm	336	15	and	and	CC
cord-022353-q2k2krnm	336	16	act	act	VB
cord-022353-q2k2krnm	336	17	on	on	IN
cord-022353-q2k2krnm	336	18	the	the	DT
cord-022353-q2k2krnm	336	19	liver	liver	NN
cord-022353-q2k2krnm	336	20	to	to	TO
cord-022353-q2k2krnm	336	21	produce	produce	VB
cord-022353-q2k2krnm	336	22	acute	acute	JJ
cord-022353-q2k2krnm	336	23	phase	phase	NN
cord-022353-q2k2krnm	336	24	reactants	reactant	NNS
cord-022353-q2k2krnm	336	25	.	.	.
cord-022353-q2k2krnm	337	1	They	-PRON-	PRP
cord-022353-q2k2krnm	337	2	also	also	RB
cord-022353-q2k2krnm	337	3	induce	induce	VBP
cord-022353-q2k2krnm	337	4	suppressor	suppressor	NN
cord-022353-q2k2krnm	337	5	of	of	IN
cord-022353-q2k2krnm	337	6	cytokine	cytokine	NN
cord-022353-q2k2krnm	337	7	signaling-3	signaling-3	NNP
cord-022353-q2k2krnm	337	8	(	(	-LRB-
cord-022353-q2k2krnm	337	9	SOCS-3	SOCS-3	NNP
cord-022353-q2k2krnm	337	10	)	)	-RRB-
cord-022353-q2k2krnm	337	11	,	,	,
cord-022353-q2k2krnm	337	12	an	an	DT
cord-022353-q2k2krnm	337	13	intracellular	intracellular	JJ
cord-022353-q2k2krnm	337	14	signaling	signaling	NN
cord-022353-q2k2krnm	337	15	molecule	molecule	NN
cord-022353-q2k2krnm	337	16	that	that	WDT
cord-022353-q2k2krnm	337	17	impairs	impair	VBZ
cord-022353-q2k2krnm	337	18	neuronal	neuronal	JJ
cord-022353-q2k2krnm	337	19	signaling	signal	VBG
cord-022353-q2k2krnm	337	20	by	by	IN
cord-022353-q2k2krnm	337	21	leptin	leptin	NN
cord-022353-q2k2krnm	337	22	and	and	CC
cord-022353-q2k2krnm	337	23	insulin	insulin	NN
cord-022353-q2k2krnm	337	24	,	,	,
cord-022353-q2k2krnm	337	25	and	and	CC
cord-022353-q2k2krnm	337	26	thus	thus	RB
cord-022353-q2k2krnm	337	27	causes	cause	VBZ
cord-022353-q2k2krnm	337	28	resistance	resistance	NN
cord-022353-q2k2krnm	337	29	to	to	IN
cord-022353-q2k2krnm	337	30	the	the	DT
cord-022353-q2k2krnm	337	31	central	central	JJ
cord-022353-q2k2krnm	337	32	actions	action	NNS
cord-022353-q2k2krnm	337	33	of	of	IN
cord-022353-q2k2krnm	337	34	both	both	DT
cord-022353-q2k2krnm	337	35	hormones	hormone	NNS
cord-022353-q2k2krnm	337	36	(	(	-LRB-
cord-022353-q2k2krnm	337	37	Schwartz	Schwartz	NNP
cord-022353-q2k2krnm	337	38	and	and	CC
cord-022353-q2k2krnm	337	39	Porte	Porte	NNP
cord-022353-q2k2krnm	337	40	2005	2005	CD
cord-022353-q2k2krnm	337	41	)	)	-RRB-
cord-022353-q2k2krnm	337	42	.	.	.
cord-022353-q2k2krnm	338	1	Resistin	Resistin	NNP
cord-022353-q2k2krnm	338	2	mediates	mediate	VBZ
cord-022353-q2k2krnm	338	3	its	-PRON-	PRP$
cord-022353-q2k2krnm	338	4	effects	effect	NNS
cord-022353-q2k2krnm	338	5	principally	principally	RB
cord-022353-q2k2krnm	338	6	by	by	IN
cord-022353-q2k2krnm	338	7	decreasing	decrease	VBG
cord-022353-q2k2krnm	338	8	the	the	DT
cord-022353-q2k2krnm	338	9	expression	expression	NN
cord-022353-q2k2krnm	338	10	of	of	IN
cord-022353-q2k2krnm	338	11	gluconeogenic	gluconeogenic	JJ
cord-022353-q2k2krnm	338	12	enzymes	enzyme	NNS
cord-022353-q2k2krnm	338	13	in	in	IN
cord-022353-q2k2krnm	338	14	the	the	DT
cord-022353-q2k2krnm	338	15	liver	liver	NN
cord-022353-q2k2krnm	338	16	(	(	-LRB-
cord-022353-q2k2krnm	338	17	Banerjee	Banerjee	NNP
cord-022353-q2k2krnm	338	18	et	et	NNP
cord-022353-q2k2krnm	338	19	al	al	NNP
cord-022353-q2k2krnm	338	20	.	.	.
cord-022353-q2k2krnm	338	21	2004	2004	CD
cord-022353-q2k2krnm	338	22	)	)	-RRB-
cord-022353-q2k2krnm	338	23	.	.	.
cord-022353-q2k2krnm	339	1	Certain	certain	JJ
cord-022353-q2k2krnm	339	2	cytokines	cytokine	NNS
cord-022353-q2k2krnm	339	3	,	,	,
cord-022353-q2k2krnm	339	4	increased	increase	VBN
cord-022353-q2k2krnm	339	5	endoplasmic	endoplasmic	NN
cord-022353-q2k2krnm	339	6	reticulum	reticulum	NN
cord-022353-q2k2krnm	339	7	stress	stress	NN
cord-022353-q2k2krnm	339	8	,	,	,
cord-022353-q2k2krnm	339	9	chronic	chronic	JJ
cord-022353-q2k2krnm	339	10	hyperglycemia	hyperglycemia	NN
cord-022353-q2k2krnm	339	11	,	,	,
cord-022353-q2k2krnm	339	12	chronic	chronic	JJ
cord-022353-q2k2krnm	339	13	hyperlipidemia	hyperlipidemia	NN
cord-022353-q2k2krnm	339	14	,	,	,
cord-022353-q2k2krnm	339	15	and	and	CC
cord-022353-q2k2krnm	339	16	oxidative	oxidative	JJ
cord-022353-q2k2krnm	339	17	stress	stress	NN
cord-022353-q2k2krnm	339	18	may	may	MD
cord-022353-q2k2krnm	339	19	all	all	DT
cord-022353-q2k2krnm	339	20	induce	induce	VB
cord-022353-q2k2krnm	339	21	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	339	22	of	of	IN
cord-022353-q2k2krnm	339	23	insulin	insulin	NN
cord-022353-q2k2krnm	339	24	producing	produce	VBG
cord-022353-q2k2krnm	339	25	~l	~l	NNP
cord-022353-q2k2krnm	339	26	-	-	HYPH
cord-022353-q2k2krnm	339	27	cells	cell	NNS
cord-022353-q2k2krnm	339	28	in	in	IN
cord-022353-q2k2krnm	339	29	the	the	DT
cord-022353-q2k2krnm	339	30	islets	islet	NNS
cord-022353-q2k2krnm	339	31	of	of	IN
cord-022353-q2k2krnm	339	32	the	the	DT
cord-022353-q2k2krnm	339	33	pancreas	pancrea	NNS
cord-022353-q2k2krnm	339	34	(	(	-LRB-
cord-022353-q2k2krnm	339	35	Rhodes	Rhodes	NNP
cord-022353-q2k2krnm	339	36	2005	2005	CD
cord-022353-q2k2krnm	339	37	)	)	-RRB-
cord-022353-q2k2krnm	339	38	.	.	.
cord-022353-q2k2krnm	340	1	Insulin	insulin	NN
cord-022353-q2k2krnm	340	2	receptor	receptor	NN
cord-022353-q2k2krnm	340	3	substrate-2	substrate-2	NNP
cord-022353-q2k2krnm	341	1	(	(	-LRB-
cord-022353-q2k2krnm	341	2	IRS-2	IRS-2	NNP
cord-022353-q2k2krnm	341	3	)	)	-RRB-
cord-022353-q2k2krnm	341	4	is	be	VBZ
cord-022353-q2k2krnm	341	5	a	a	DT
cord-022353-q2k2krnm	341	6	key	key	JJ
cord-022353-q2k2krnm	341	7	molecule	molecule	NN
cord-022353-q2k2krnm	341	8	promoting	promote	VBG
cord-022353-q2k2krnm	341	9	~-cell	~-cell	ADD
cord-022353-q2k2krnm	341	10	growth	growth	NN
cord-022353-q2k2krnm	341	11	and	and	CC
cord-022353-q2k2krnm	341	12	survival	survival	NN
cord-022353-q2k2krnm	341	13	.	.	.
cord-022353-q2k2krnm	342	1	These	these	DT
cord-022353-q2k2krnm	342	2	molecules	molecule	NNS
cord-022353-q2k2krnm	342	3	act	act	VBP
cord-022353-q2k2krnm	342	4	immediately	immediately	RB
cord-022353-q2k2krnm	342	5	downstream	downstream	RB
cord-022353-q2k2krnm	342	6	from	from	IN
cord-022353-q2k2krnm	342	7	surface	surface	NN
cord-022353-q2k2krnm	342	8	receptors	receptor	NNS
cord-022353-q2k2krnm	342	9	for	for	IN
cord-022353-q2k2krnm	342	10	insulin	insulin	NN
cord-022353-q2k2krnm	342	11	and	and	CC
cord-022353-q2k2krnm	342	12	insulin	insulin	NN
cord-022353-q2k2krnm	342	13	-	-	HYPH
cord-022353-q2k2krnm	342	14	like	like	JJ
cord-022353-q2k2krnm	342	15	growth	growth	NN
cord-022353-q2k2krnm	342	16	factor-1	factor-1	NNP
cord-022353-q2k2krnm	342	17	and	and	CC
cord-022353-q2k2krnm	342	18	inhibition	inhibition	NN
cord-022353-q2k2krnm	342	19	of	of	IN
cord-022353-q2k2krnm	342	20	IRS-2	IRS-2	NNP
cord-022353-q2k2krnm	342	21	has	have	VBZ
cord-022353-q2k2krnm	342	22	been	be	VBN
cord-022353-q2k2krnm	342	23	shown	show	VBN
cord-022353-q2k2krnm	342	24	to	to	TO
cord-022353-q2k2krnm	342	25	lead	lead	VB
cord-022353-q2k2krnm	342	26	to	to	IN
cord-022353-q2k2krnm	342	27	insulin	insulin	NN
cord-022353-q2k2krnm	342	28	resistance	resistance	NN
cord-022353-q2k2krnm	342	29	.	.	.
cord-022353-q2k2krnm	343	1	Inhibition	inhibition	NN
cord-022353-q2k2krnm	343	2	may	may	MD
cord-022353-q2k2krnm	343	3	result	result	VB
cord-022353-q2k2krnm	343	4	from	from	IN
cord-022353-q2k2krnm	343	5	accumulation	accumulation	NN
cord-022353-q2k2krnm	343	6	of	of	IN
cord-022353-q2k2krnm	343	7	reactive	reactive	JJ
cord-022353-q2k2krnm	343	8	oxygen	oxygen	NN
cord-022353-q2k2krnm	343	9	species	specie	NNS
cord-022353-q2k2krnm	343	10	in	in	IN
cord-022353-q2k2krnm	343	11	~-cells	~-cell	NNS
cord-022353-q2k2krnm	343	12	chronically	chronically	RB
cord-022353-q2k2krnm	343	13	exposed	expose	VBN
cord-022353-q2k2krnm	343	14	to	to	IN
cord-022353-q2k2krnm	343	15	increased	increase	VBN
cord-022353-q2k2krnm	343	16	glucose	glucose	NN
cord-022353-q2k2krnm	343	17	metabolism	metabolism	NN
cord-022353-q2k2krnm	343	18	or	or	CC
cord-022353-q2k2krnm	343	19	from	from	IN
cord-022353-q2k2krnm	343	20	chronic	chronic	JJ
cord-022353-q2k2krnm	343	21	exposure	exposure	NN
cord-022353-q2k2krnm	343	22	to	to	IN
cord-022353-q2k2krnm	343	23	elevated	elevated	JJ
cord-022353-q2k2krnm	343	24	fatty	fatty	JJ
cord-022353-q2k2krnm	343	25	acid	acid	NN
cord-022353-q2k2krnm	343	26	(	(	-LRB-
cord-022353-q2k2krnm	343	27	which	which	WDT
cord-022353-q2k2krnm	343	28	through	through	IN
cord-022353-q2k2krnm	343	29	production	production	NN
cord-022353-q2k2krnm	343	30	of	of	IN
cord-022353-q2k2krnm	343	31	long	long	JJ
cord-022353-q2k2krnm	343	32	chain	chain	NN
cord-022353-q2k2krnm	343	33	acyl	acyl	NN
cord-022353-q2k2krnm	343	34	-	-	HYPH
cord-022353-q2k2krnm	343	35	CoA	coa	NN
cord-022353-q2k2krnm	343	36	active	active	JJ
cord-022353-q2k2krnm	343	37	protein	protein	NN
cord-022353-q2k2krnm	343	38	kinase	kinase	NN
cord-022353-q2k2krnm	343	39	C	c	NN
cord-022353-q2k2krnm	343	40	-	-	HYPH
cord-022353-q2k2krnm	343	41	isoforms	isoform	NNS
cord-022353-q2k2krnm	343	42	degrade	degrade	VBP
cord-022353-q2k2krnm	343	43	IRS-2	IRS-2	NNP
cord-022353-q2k2krnm	343	44	)	)	-RRB-
cord-022353-q2k2krnm	343	45	.	.	.
cord-022353-q2k2krnm	344	1	Leptin	leptin	NN
cord-022353-q2k2krnm	344	2	has	have	VBZ
cord-022353-q2k2krnm	344	3	been	be	VBN
cord-022353-q2k2krnm	344	4	shown	show	VBN
cord-022353-q2k2krnm	344	5	to	to	TO
cord-022353-q2k2krnm	344	6	modulate	modulate	VB
cord-022353-q2k2krnm	344	7	interleukin	interleukin	NN
cord-022353-q2k2krnm	344	8	-	-	HYPH
cord-022353-q2k2krnm	344	9	l~	l~	XX
cord-022353-q2k2krnm	345	1	(	(	-LRB-
cord-022353-q2k2krnm	345	2	IL	IL	NNP
cord-022353-q2k2krnm	345	3	-	-	HYPH
cord-022353-q2k2krnm	345	4	I~	I~	NNP
cord-022353-q2k2krnm	345	5	)	)	-RRB-
cord-022353-q2k2krnm	345	6	,	,	,
cord-022353-q2k2krnm	345	7	a	a	DT
cord-022353-q2k2krnm	345	8	potent	potent	JJ
cord-022353-q2k2krnm	345	9	inducer	inducer	NN
cord-022353-q2k2krnm	345	10	of	of	IN
cord-022353-q2k2krnm	345	11	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	345	12	.	.	.
cord-022353-q2k2krnm	346	1	TNF	TNF	NNP
cord-022353-q2k2krnm	346	2	-	-	HYPH
cord-022353-q2k2krnm	346	3	t~	t~	NNP
cord-022353-q2k2krnm	347	1	and	and	CC
cord-022353-q2k2krnm	347	2	IL-6	IL-6	NNP
cord-022353-q2k2krnm	347	3	induce	induce	VB
cord-022353-q2k2krnm	347	4	~-cell	~-cell	NFP
cord-022353-q2k2krnm	348	1	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	348	2	by	by	IN
cord-022353-q2k2krnm	348	3	activating	activate	VBG
cord-022353-q2k2krnm	348	4	the	the	DT
cord-022353-q2k2krnm	348	5	transcription	transcription	NN
cord-022353-q2k2krnm	348	6	factor	factor	NN
cord-022353-q2k2krnm	348	7	nuclear	nuclear	JJ
cord-022353-q2k2krnm	348	8	factor	factor	NN
cord-022353-q2k2krnm	348	9	K	K	NNP
cord-022353-q2k2krnm	348	10	:	:	:
cord-022353-q2k2krnm	348	11	I	i	NN
cord-022353-q2k2krnm	348	12	]	]	-RRB-
cord-022353-q2k2krnm	348	13	(	(	-LRB-
cord-022353-q2k2krnm	348	14	NF-~:[3	NF-~:[3	NNP
cord-022353-q2k2krnm	348	15	)	)	-RRB-
cord-022353-q2k2krnm	348	16	.	.	.
cord-022353-q2k2krnm	349	1	Centrally	centrally	RB
cord-022353-q2k2krnm	349	2	the	the	DT
cord-022353-q2k2krnm	349	3	actions	action	NNS
cord-022353-q2k2krnm	349	4	of	of	IN
cord-022353-q2k2krnm	349	5	both	both	DT
cord-022353-q2k2krnm	349	6	insulin	insulin	NN
cord-022353-q2k2krnm	349	7	and	and	CC
cord-022353-q2k2krnm	349	8	leptin	leptin	NN
cord-022353-q2k2krnm	349	9	take	take	VBP
cord-022353-q2k2krnm	349	10	place	place	NN
cord-022353-q2k2krnm	349	11	in	in	IN
cord-022353-q2k2krnm	349	12	the	the	DT
cord-022353-q2k2krnm	349	13	mediobasal	mediobasal	NNP
cord-022353-q2k2krnm	349	14	hypothalamus	hypothalamus	NNP
cord-022353-q2k2krnm	349	15	,	,	,
cord-022353-q2k2krnm	349	16	where	where	WRB
cord-022353-q2k2krnm	349	17	the	the	DT
cord-022353-q2k2krnm	349	18	neurons	neuron	NNS
cord-022353-q2k2krnm	349	19	exert	exert	VBP
cord-022353-q2k2krnm	349	20	potent	potent	JJ
cord-022353-q2k2krnm	349	21	effects	effect	NNS
cord-022353-q2k2krnm	349	22	on	on	IN
cord-022353-q2k2krnm	349	23	food	food	NN
cord-022353-q2k2krnm	349	24	intake	intake	NN
cord-022353-q2k2krnm	349	25	and	and	CC
cord-022353-q2k2krnm	349	26	energy	energy	NN
cord-022353-q2k2krnm	349	27	expenditure	expenditure	NN
cord-022353-q2k2krnm	349	28	.	.	.
cord-022353-q2k2krnm	350	1	Here	here	RB
cord-022353-q2k2krnm	350	2	neurons	neuron	NNS
cord-022353-q2k2krnm	350	3	co	co	VBP
cord-022353-q2k2krnm	350	4	-	-	JJ
cord-022353-q2k2krnm	350	5	express	express	JJ
cord-022353-q2k2krnm	350	6	neuropeptide	neuropeptide	NN
cord-022353-q2k2krnm	350	7	Y	Y	NNP
cord-022353-q2k2krnm	350	8	(	(	-LRB-
cord-022353-q2k2krnm	350	9	NPY	NPY	NNP
cord-022353-q2k2krnm	350	10	)	)	-RRB-
cord-022353-q2k2krnm	350	11	and	and	CC
cord-022353-q2k2krnm	350	12	Agouti	Agouti	NNP
cord-022353-q2k2krnm	350	13	-	-	HYPH
cord-022353-q2k2krnm	350	14	related	relate	VBN
cord-022353-q2k2krnm	350	15	peptide	peptide	NN
cord-022353-q2k2krnm	350	16	(	(	-LRB-
cord-022353-q2k2krnm	350	17	AgRP	AgRP	NNP
cord-022353-q2k2krnm	350	18	)	)	-RRB-
cord-022353-q2k2krnm	350	19	,	,	,
cord-022353-q2k2krnm	350	20	which	which	WDT
cord-022353-q2k2krnm	350	21	stimulate	stimulate	VBP
cord-022353-q2k2krnm	350	22	food	food	NN
cord-022353-q2k2krnm	350	23	intake	intake	NN
cord-022353-q2k2krnm	350	24	and	and	CC
cord-022353-q2k2krnm	350	25	reduce	reduce	VB
cord-022353-q2k2krnm	350	26	energy	energy	NN
cord-022353-q2k2krnm	350	27	expenditure	expenditure	NN
cord-022353-q2k2krnm	350	28	.	.	.
cord-022353-q2k2krnm	351	1	Leptin	leptin	NN
cord-022353-q2k2krnm	351	2	and	and	CC
cord-022353-q2k2krnm	351	3	insulin	insulin	NN
cord-022353-q2k2krnm	351	4	inhibit	inhibit	VBP
cord-022353-q2k2krnm	351	5	these	these	DT
cord-022353-q2k2krnm	351	6	neurons	neuron	NNS
cord-022353-q2k2krnm	351	7	.	.	.
cord-022353-q2k2krnm	352	1	Under	under	IN
cord-022353-q2k2krnm	352	2	conditions	condition	NNS
cord-022353-q2k2krnm	352	3	of	of	IN
cord-022353-q2k2krnm	352	4	reduced	reduced	JJ
cord-022353-q2k2krnm	352	5	leptin	leptin	NN
cord-022353-q2k2krnm	352	6	and	and	CC
cord-022353-q2k2krnm	352	7	insulin	insulin	NN
cord-022353-q2k2krnm	352	8	signaling	signaling	NN
cord-022353-q2k2krnm	352	9	,	,	,
cord-022353-q2k2krnm	352	10	NPY	NPY	NNP
cord-022353-q2k2krnm	352	11	increases	increase	NNS
cord-022353-q2k2krnm	352	12	,	,	,
cord-022353-q2k2krnm	352	13	inducing	induce	VBG
cord-022353-q2k2krnm	352	14	hyperphagia	hyperphagia	NNP
cord-022353-q2k2krnm	352	15	,	,	,
cord-022353-q2k2krnm	352	16	weight	weight	NN
cord-022353-q2k2krnm	352	17	gain	gain	NN
cord-022353-q2k2krnm	352	18	,	,	,
cord-022353-q2k2krnm	352	19	insulin	insulin	NN
cord-022353-q2k2krnm	352	20	resistance	resistance	NN
cord-022353-q2k2krnm	352	21	,	,	,
cord-022353-q2k2krnm	352	22	and	and	CC
cord-022353-q2k2krnm	352	23	glucose	glucose	NN
cord-022353-q2k2krnm	352	24	intolerance	intolerance	NN
cord-022353-q2k2krnm	352	25	.	.	.
cord-022353-q2k2krnm	353	1	The	the	DT
cord-022353-q2k2krnm	353	2	anabolic	anabolic	JJ
cord-022353-q2k2krnm	353	3	effects	effect	NNS
cord-022353-q2k2krnm	353	4	of	of	IN
cord-022353-q2k2krnm	353	5	AgRP	agrp	NN
cord-022353-q2k2krnm	353	6	arise	arise	NN
cord-022353-q2k2krnm	353	7	from	from	IN
cord-022353-q2k2krnm	353	8	its	-PRON-	PRP$
cord-022353-q2k2krnm	353	9	antagonism	antagonism	NN
cord-022353-q2k2krnm	353	10	of	of	IN
cord-022353-q2k2krnm	353	11	the	the	DT
cord-022353-q2k2krnm	353	12	melanocortin	melanocortin	NNP
cord-022353-q2k2krnm	353	13	receptors	receptor	NNS
cord-022353-q2k2krnm	353	14	MC3r	MC3r	NNP
cord-022353-q2k2krnm	353	15	and	and	CC
cord-022353-q2k2krnm	353	16	MC4r	MC4r	NNP
cord-022353-q2k2krnm	353	17	,	,	,
cord-022353-q2k2krnm	353	18	which	which	WDT
cord-022353-q2k2krnm	353	19	serve	serve	VBP
cord-022353-q2k2krnm	353	20	to	to	TO
cord-022353-q2k2krnm	353	21	limit	limit	VB
cord-022353-q2k2krnm	353	22	food	food	NN
cord-022353-q2k2krnm	353	23	intake	intake	NN
cord-022353-q2k2krnm	353	24	.	.	.
cord-022353-q2k2krnm	354	1	Blockage	blockage	NN
cord-022353-q2k2krnm	354	2	of	of	IN
cord-022353-q2k2krnm	354	3	MC3r	MC3r	NNP
cord-022353-q2k2krnm	354	4	and	and	CC
cord-022353-q2k2krnm	354	5	MC4r	MC4r	NNP
cord-022353-q2k2krnm	354	6	leads	lead	VBZ
cord-022353-q2k2krnm	354	7	to	to	IN
cord-022353-q2k2krnm	354	8	weight	weight	NN
cord-022353-q2k2krnm	354	9	gain	gain	NN
cord-022353-q2k2krnm	354	10	and	and	CC
cord-022353-q2k2krnm	354	11	insulin	insulin	NN
cord-022353-q2k2krnm	354	12	resistance	resistance	NN
cord-022353-q2k2krnm	354	13	.	.	.
cord-022353-q2k2krnm	355	1	Precursor	precursor	NN
cord-022353-q2k2krnm	355	2	proopiomelanocortin	proopiomelanocortin	NNS
cord-022353-q2k2krnm	355	3	(	(	-LRB-
cord-022353-q2k2krnm	355	4	POMC	POMC	NNP
cord-022353-q2k2krnm	355	5	)	)	-RRB-
cord-022353-q2k2krnm	355	6	and	and	CC
cord-022353-q2k2krnm	355	7	POMC	POMC	NNP
cord-022353-q2k2krnm	355	8	neurons	neuron	NNS
cord-022353-q2k2krnm	355	9	in	in	IN
cord-022353-q2k2krnm	355	10	the	the	DT
cord-022353-q2k2krnm	355	11	arcuate	arcuate	JJ
cord-022353-q2k2krnm	355	12	nucleus	nucleus	NN
cord-022353-q2k2krnm	355	13	are	be	VBP
cord-022353-q2k2krnm	355	14	stimulated	stimulate	VBN
cord-022353-q2k2krnm	355	15	by	by	IN
cord-022353-q2k2krnm	355	16	leptin	leptin	NN
cord-022353-q2k2krnm	355	17	and	and	CC
cord-022353-q2k2krnm	355	18	insulin	insulin	NN
cord-022353-q2k2krnm	355	19	and	and	CC
cord-022353-q2k2krnm	355	20	the	the	DT
cord-022353-q2k2krnm	355	21	resultant	resultant	JJ
cord-022353-q2k2krnm	355	22	production	production	NN
cord-022353-q2k2krnm	355	23	of	of	IN
cord-022353-q2k2krnm	355	24	melanocortin	melanocortin	NNP
cord-022353-q2k2krnm	355	25	and	and	CC
cord-022353-q2k2krnm	355	26	its	-PRON-	PRP$
cord-022353-q2k2krnm	355	27	binding	binding	NN
cord-022353-q2k2krnm	355	28	to	to	IN
cord-022353-q2k2krnm	355	29	MC3r	MC3r	NNP
cord-022353-q2k2krnm	355	30	and	and	CC
cord-022353-q2k2krnm	355	31	MC4r	MC4r	NNP
cord-022353-q2k2krnm	355	32	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	355	33	food	food	NN
cord-022353-q2k2krnm	355	34	intake	intake	NN
cord-022353-q2k2krnm	355	35	and	and	CC
cord-022353-q2k2krnm	355	36	promotes	promote	VBZ
cord-022353-q2k2krnm	355	37	weight	weight	NN
cord-022353-q2k2krnm	355	38	loss	loss	NN
cord-022353-q2k2krnm	355	39	(	(	-LRB-
cord-022353-q2k2krnm	355	40	Schwartz	Schwartz	NNP
cord-022353-q2k2krnm	355	41	and	and	CC
cord-022353-q2k2krnm	355	42	Porte	Porte	NNP
cord-022353-q2k2krnm	355	43	2005	2005	CD
cord-022353-q2k2krnm	355	44	)	)	-RRB-
cord-022353-q2k2krnm	355	45	.	.	.
cord-022353-q2k2krnm	356	1	However	however	RB
cord-022353-q2k2krnm	356	2	,	,	,
cord-022353-q2k2krnm	356	3	in	in	IN
cord-022353-q2k2krnm	356	4	the	the	DT
cord-022353-q2k2krnm	356	5	absence	absence	NN
cord-022353-q2k2krnm	356	6	of	of	IN
cord-022353-q2k2krnm	356	7	leptin	leptin	NN
cord-022353-q2k2krnm	356	8	,	,	,
cord-022353-q2k2krnm	356	9	as	as	IN
cord-022353-q2k2krnm	356	10	seen	see	VBN
cord-022353-q2k2krnm	356	11	in	in	IN
cord-022353-q2k2krnm	356	12	Lep	Lep	NNP
cord-022353-q2k2krnm	356	13	~176	~176	NNP
cord-022353-q2k2krnm	356	14	mice	mouse	NNS
cord-022353-q2k2krnm	356	15	,	,	,
cord-022353-q2k2krnm	356	16	neurons	neuron	NNS
cord-022353-q2k2krnm	356	17	of	of	IN
cord-022353-q2k2krnm	356	18	the	the	DT
cord-022353-q2k2krnm	356	19	arcuate	arcuate	JJ
cord-022353-q2k2krnm	356	20	nucleus	nucleus	NN
cord-022353-q2k2krnm	356	21	of	of	IN
cord-022353-q2k2krnm	356	22	the	the	DT
cord-022353-q2k2krnm	356	23	hypothalamus	hypothalamus	NN
cord-022353-q2k2krnm	356	24	are	be	VBP
cord-022353-q2k2krnm	356	25	permanently	permanently	RB
cord-022353-q2k2krnm	356	26	disrupted	disrupt	VBN
cord-022353-q2k2krnm	356	27	and	and	CC
cord-022353-q2k2krnm	356	28	treatment	treatment	NN
cord-022353-q2k2krnm	356	29	in	in	IN
cord-022353-q2k2krnm	356	30	adulthood	adulthood	NN
cord-022353-q2k2krnm	356	31	can	can	MD
cord-022353-q2k2krnm	356	32	not	not	RB
cord-022353-q2k2krnm	356	33	reverse	reverse	VB
cord-022353-q2k2krnm	356	34	this	this	DT
cord-022353-q2k2krnm	356	35	defect	defect	NN
cord-022353-q2k2krnm	356	36	(	(	-LRB-
cord-022353-q2k2krnm	356	37	Bouret	Bouret	NNP
cord-022353-q2k2krnm	356	38	et	et	FW
cord-022353-q2k2krnm	356	39	al	al	NNP
cord-022353-q2k2krnm	356	40	.	.	.
cord-022353-q2k2krnm	356	41	2004	2004	CD
cord-022353-q2k2krnm	356	42	)	)	-RRB-
cord-022353-q2k2krnm	356	43	.	.	.
cord-022353-q2k2krnm	357	1	Orexin	orexin	NN
cord-022353-q2k2krnm	357	2	A	a	DT
cord-022353-q2k2krnm	357	3	(	(	-LRB-
cord-022353-q2k2krnm	357	4	hypocretin-1	hypocretin-1	NNP
cord-022353-q2k2krnm	357	5	)	)	-RRB-
cord-022353-q2k2krnm	357	6	and	and	CC
cord-022353-q2k2krnm	357	7	orexin	orexin	NN
cord-022353-q2k2krnm	357	8	B	b	NN
cord-022353-q2k2krnm	357	9	(	(	-LRB-
cord-022353-q2k2krnm	357	10	hypocretin-2	hypocretin-2	NNP
cord-022353-q2k2krnm	357	11	)	)	-RRB-
cord-022353-q2k2krnm	357	12	are	be	VBP
cord-022353-q2k2krnm	357	13	neuropeptides	neuropeptide	NNS
cord-022353-q2k2krnm	357	14	produced	produce	VBN
cord-022353-q2k2krnm	357	15	in	in	IN
cord-022353-q2k2krnm	357	16	the	the	DT
cord-022353-q2k2krnm	357	17	lateral	lateral	JJ
cord-022353-q2k2krnm	357	18	hypothalamus	hypothalamus	NN
cord-022353-q2k2krnm	357	19	by	by	IN
cord-022353-q2k2krnm	357	20	neurons	neuron	NNS
cord-022353-q2k2krnm	357	21	with	with	IN
cord-022353-q2k2krnm	357	22	axonal	axonal	JJ
cord-022353-q2k2krnm	357	23	projections	projection	NNS
cord-022353-q2k2krnm	357	24	to	to	IN
cord-022353-q2k2krnm	357	25	many	many	JJ
cord-022353-q2k2krnm	357	26	sites	site	NNS
cord-022353-q2k2krnm	357	27	including	include	VBG
cord-022353-q2k2krnm	357	28	those	those	DT
cord-022353-q2k2krnm	357	29	that	that	WDT
cord-022353-q2k2krnm	357	30	control	control	NN
cord-022353-q2k2krnm	357	31	feeding	feeding	NN
cord-022353-q2k2krnm	357	32	behavior	behavior	NN
cord-022353-q2k2krnm	357	33	and	and	CC
cord-022353-q2k2krnm	357	34	sleep	sleep	NN
cord-022353-q2k2krnm	357	35	/	/	SYM
cord-022353-q2k2krnm	357	36	wakefulness	wakefulness	NN
cord-022353-q2k2krnm	357	37	(	(	-LRB-
cord-022353-q2k2krnm	357	38	Taylor	Taylor	NNP
cord-022353-q2k2krnm	357	39	and	and	CC
cord-022353-q2k2krnm	357	40	Samson	Samson	NNP
cord-022353-q2k2krnm	357	41	2003	2003	CD
cord-022353-q2k2krnm	357	42	)	)	-RRB-
cord-022353-q2k2krnm	357	43	.	.	.
cord-022353-q2k2krnm	358	1	Orexin	orexin	NN
cord-022353-q2k2krnm	358	2	KO	KO	NNP
cord-022353-q2k2krnm	358	3	mice	mouse	NNS
cord-022353-q2k2krnm	358	4	develop	develop	VBP
cord-022353-q2k2krnm	358	5	hypophagia	hypophagia	NN
cord-022353-q2k2krnm	358	6	with	with	IN
cord-022353-q2k2krnm	358	7	obesity	obesity	NN
cord-022353-q2k2krnm	358	8	and	and	CC
cord-022353-q2k2krnm	358	9	insulin	insulin	NN
cord-022353-q2k2krnm	358	10	-	-	HYPH
cord-022353-q2k2krnm	358	11	resistant	resistant	JJ
cord-022353-q2k2krnm	358	12	diabetes	diabete	NNS
cord-022353-q2k2krnm	359	1	(	(	-LRB-
cord-022353-q2k2krnm	359	2	Hara	Hara	NNP
cord-022353-q2k2krnm	359	3	et	et	NNP
cord-022353-q2k2krnm	359	4	al	al	NNP
cord-022353-q2k2krnm	359	5	.	.	NNP
cord-022353-q2k2krnm	359	6	2001	2001	CD
cord-022353-q2k2krnm	359	7	)	)	-RRB-
cord-022353-q2k2krnm	359	8	.	.	.
cord-022353-q2k2krnm	360	1	Ghrelin	Ghrelin	NNP
cord-022353-q2k2krnm	360	2	,	,	,
cord-022353-q2k2krnm	360	3	a	a	DT
cord-022353-q2k2krnm	360	4	peptide	peptide	NN
cord-022353-q2k2krnm	360	5	made	make	VBN
cord-022353-q2k2krnm	360	6	predominantly	predominantly	RB
cord-022353-q2k2krnm	360	7	by	by	IN
cord-022353-q2k2krnm	360	8	the	the	DT
cord-022353-q2k2krnm	360	9	stomach	stomach	NN
cord-022353-q2k2krnm	360	10	,	,	,
cord-022353-q2k2krnm	360	11	is	be	VBZ
cord-022353-q2k2krnm	360	12	also	also	RB
cord-022353-q2k2krnm	360	13	known	know	VBN
cord-022353-q2k2krnm	360	14	to	to	TO
cord-022353-q2k2krnm	360	15	act	act	VB
cord-022353-q2k2krnm	360	16	centrally	centrally	RB
cord-022353-q2k2krnm	360	17	and	and	CC
cord-022353-q2k2krnm	360	18	affect	affect	VB
cord-022353-q2k2krnm	360	19	food	food	NN
cord-022353-q2k2krnm	360	20	intake	intake	NN
cord-022353-q2k2krnm	360	21	and	and	CC
cord-022353-q2k2krnm	360	22	increase	increase	VB
cord-022353-q2k2krnm	360	23	secretion	secretion	NN
cord-022353-q2k2krnm	360	24	of	of	IN
cord-022353-q2k2krnm	360	25	GH	GH	NNP
cord-022353-q2k2krnm	360	26	(	(	-LRB-
cord-022353-q2k2krnm	360	27	Ghigo	Ghigo	NNP
cord-022353-q2k2krnm	360	28	et	et	NNP
cord-022353-q2k2krnm	360	29	al	al	NNP
cord-022353-q2k2krnm	360	30	.	.	.
cord-022353-q2k2krnm	361	1	2004	2004	CD
cord-022353-q2k2krnm	361	2	;	;	:
cord-022353-q2k2krnm	361	3	Korbonits	Korbonits	NNP
cord-022353-q2k2krnm	361	4	et	et	NNP
cord-022353-q2k2krnm	361	5	al	al	NNP
cord-022353-q2k2krnm	361	6	.	.	.
cord-022353-q2k2krnm	361	7	2004	2004	CD
cord-022353-q2k2krnm	361	8	)	)	-RRB-
cord-022353-q2k2krnm	361	9	.	.	.
cord-022353-q2k2krnm	362	1	In	in	IN
cord-022353-q2k2krnm	362	2	the	the	DT
cord-022353-q2k2krnm	362	3	periphery	periphery	JJ
cord-022353-q2k2krnm	362	4	leptin	leptin	NN
cord-022353-q2k2krnm	362	5	has	have	VBZ
cord-022353-q2k2krnm	362	6	been	be	VBN
cord-022353-q2k2krnm	362	7	shown	show	VBN
cord-022353-q2k2krnm	362	8	to	to	TO
cord-022353-q2k2krnm	362	9	specifically	specifically	RB
cord-022353-q2k2krnm	362	10	repress	repress	VB
cord-022353-q2k2krnm	362	11	RNA	RNA	NNP
cord-022353-q2k2krnm	362	12	levels	level	NNS
cord-022353-q2k2krnm	362	13	and	and	CC
cord-022353-q2k2krnm	362	14	enzymatic	enzymatic	JJ
cord-022353-q2k2krnm	362	15	activity	activity	NN
cord-022353-q2k2krnm	362	16	of	of	IN
cord-022353-q2k2krnm	362	17	hepatic	hepatic	JJ
cord-022353-q2k2krnm	362	18	stearoyl	stearoyl	NN
cord-022353-q2k2krnm	362	19	-	-	HYPH
cord-022353-q2k2krnm	362	20	CoA	coa	NN
cord-022353-q2k2krnm	362	21	desaturase-1	desaturase-1	NNP
cord-022353-q2k2krnm	362	22	(	(	-LRB-
cord-022353-q2k2krnm	362	23	SLD-1	SLD-1	NNP
cord-022353-q2k2krnm	362	24	)	)	-RRB-
cord-022353-q2k2krnm	362	25	,	,	,
cord-022353-q2k2krnm	362	26	which	which	WDT
cord-022353-q2k2krnm	362	27	catalyzes	catalyze	VBZ
cord-022353-q2k2krnm	362	28	the	the	DT
cord-022353-q2k2krnm	362	29	biosynthesis	biosynthesis	NN
cord-022353-q2k2krnm	362	30	of	of	IN
cord-022353-q2k2krnm	362	31	monounsaturated	monounsaturated	JJ
cord-022353-q2k2krnm	362	32	fatty	fatty	JJ
cord-022353-q2k2krnm	362	33	acids	acid	NNS
cord-022353-q2k2krnm	362	34	.	.	.
cord-022353-q2k2krnm	363	1	This	this	DT
cord-022353-q2k2krnm	363	2	effect	effect	NN
cord-022353-q2k2krnm	363	3	was	be	VBD
cord-022353-q2k2krnm	363	4	found	find	VBN
cord-022353-q2k2krnm	363	5	to	to	TO
cord-022353-q2k2krnm	363	6	be	be	VB
cord-022353-q2k2krnm	363	7	an	an	DT
cord-022353-q2k2krnm	363	8	important	important	JJ
cord-022353-q2k2krnm	363	9	metabolic	metabolic	JJ
cord-022353-q2k2krnm	363	10	action	action	NN
cord-022353-q2k2krnm	363	11	of	of	IN
cord-022353-q2k2krnm	363	12	leptin	leptin	NN
cord-022353-q2k2krnm	363	13	(	(	-LRB-
cord-022353-q2k2krnm	363	14	Cohen	Cohen	NNP
cord-022353-q2k2krnm	363	15	et	et	NNP
cord-022353-q2k2krnm	363	16	al	al	NNP
cord-022353-q2k2krnm	363	17	.	.	.
cord-022353-q2k2krnm	363	18	2002	2002	CD
cord-022353-q2k2krnm	363	19	)	)	-RRB-
cord-022353-q2k2krnm	363	20	.	.	.
cord-022353-q2k2krnm	364	1	Leptin	leptin	NN
cord-022353-q2k2krnm	364	2	resistance	resistance	NN
cord-022353-q2k2krnm	364	3	,	,	,
cord-022353-q2k2krnm	364	4	a	a	DT
cord-022353-q2k2krnm	364	5	common	common	JJ
cord-022353-q2k2krnm	364	6	feature	feature	NN
cord-022353-q2k2krnm	364	7	of	of	IN
cord-022353-q2k2krnm	364	8	obesity	obesity	NN
cord-022353-q2k2krnm	364	9	in	in	IN
cord-022353-q2k2krnm	364	10	mice	mouse	NNS
cord-022353-q2k2krnm	364	11	and	and	CC
cord-022353-q2k2krnm	364	12	humans	human	NNS
cord-022353-q2k2krnm	364	13	,	,	,
cord-022353-q2k2krnm	364	14	has	have	VBZ
cord-022353-q2k2krnm	364	15	also	also	RB
cord-022353-q2k2krnm	364	16	been	be	VBN
cord-022353-q2k2krnm	364	17	shown	show	VBN
cord-022353-q2k2krnm	364	18	to	to	TO
cord-022353-q2k2krnm	364	19	result	result	VB
cord-022353-q2k2krnm	364	20	,	,	,
cord-022353-q2k2krnm	364	21	in	in	IN
cord-022353-q2k2krnm	364	22	part	part	NN
cord-022353-q2k2krnm	364	23	,	,	,
cord-022353-q2k2krnm	364	24	from	from	IN
cord-022353-q2k2krnm	364	25	the	the	DT
cord-022353-q2k2krnm	364	26	shedding	shedding	NN
cord-022353-q2k2krnm	364	27	of	of	IN
cord-022353-q2k2krnm	364	28	membrane	membrane	NN
cord-022353-q2k2krnm	364	29	-	-	HYPH
cord-022353-q2k2krnm	364	30	bound	bind	VBN
cord-022353-q2k2krnm	364	31	hepatic	hepatic	JJ
cord-022353-q2k2krnm	364	32	leptin	leptin	NN
cord-022353-q2k2krnm	364	33	receptors	receptor	NNS
cord-022353-q2k2krnm	364	34	into	into	IN
cord-022353-q2k2krnm	364	35	the	the	DT
cord-022353-q2k2krnm	364	36	plasma	plasma	NN
cord-022353-q2k2krnm	364	37	,	,	,
cord-022353-q2k2krnm	364	38	where	where	WRB
cord-022353-q2k2krnm	364	39	soluble	soluble	JJ
cord-022353-q2k2krnm	364	40	receptors	receptor	NNS
cord-022353-q2k2krnm	364	41	modulate	modulate	VBP
cord-022353-q2k2krnm	364	42	circulating	circulate	VBG
cord-022353-q2k2krnm	364	43	leptin	leptin	NN
cord-022353-q2k2krnm	364	44	levels	level	NNS
cord-022353-q2k2krnm	364	45	and	and	CC
cord-022353-q2k2krnm	364	46	possibly	possibly	RB
cord-022353-q2k2krnm	364	47	its	-PRON-	PRP$
cord-022353-q2k2krnm	364	48	biologic	biologic	JJ
cord-022353-q2k2krnm	364	49	activity	activity	NN
cord-022353-q2k2krnm	365	1	(	(	-LRB-
cord-022353-q2k2krnm	365	2	Cohen	Cohen	NNP
cord-022353-q2k2krnm	365	3	et	et	NNP
cord-022353-q2k2krnm	365	4	al	al	NNP
cord-022353-q2k2krnm	365	5	.	.	NNP
cord-022353-q2k2krnm	365	6	2005	2005	CD
cord-022353-q2k2krnm	365	7	)	)	-RRB-
cord-022353-q2k2krnm	365	8	.	.	.
cord-022353-q2k2krnm	366	1	Thus	thus	RB
cord-022353-q2k2krnm	366	2	the	the	DT
cord-022353-q2k2krnm	366	3	connections	connection	NNS
cord-022353-q2k2krnm	366	4	between	between	IN
cord-022353-q2k2krnm	366	5	factors	factor	NNS
cord-022353-q2k2krnm	366	6	regulating	regulate	VBG
cord-022353-q2k2krnm	366	7	obesity	obesity	NN
cord-022353-q2k2krnm	366	8	and	and	CC
cord-022353-q2k2krnm	366	9	insulin	insulin	NN
cord-022353-q2k2krnm	366	10	resistance	resistance	NN
cord-022353-q2k2krnm	366	11	(	(	-LRB-
cord-022353-q2k2krnm	366	12	diabetes	diabetes	NN
cord-022353-q2k2krnm	366	13	)	)	-RRB-
cord-022353-q2k2krnm	366	14	are	be	VBP
cord-022353-q2k2krnm	366	15	complex	complex	JJ
cord-022353-q2k2krnm	366	16	and	and	CC
cord-022353-q2k2krnm	366	17	occur	occur	VBP
cord-022353-q2k2krnm	366	18	both	both	CC
cord-022353-q2k2krnm	366	19	centrally	centrally	RB
cord-022353-q2k2krnm	366	20	and	and	CC
cord-022353-q2k2krnm	366	21	peripherally	peripherally	RB
cord-022353-q2k2krnm	366	22	.	.	.
cord-022353-q2k2krnm	367	1	Further	further	JJ
cord-022353-q2k2krnm	367	2	investigations	investigation	NNS
cord-022353-q2k2krnm	367	3	in	in	IN
cord-022353-q2k2krnm	367	4	mice	mouse	NNS
cord-022353-q2k2krnm	367	5	will	will	MD
cord-022353-q2k2krnm	367	6	involve	involve	VB
cord-022353-q2k2krnm	367	7	quantifying	quantify	VBG
cord-022353-q2k2krnm	367	8	glucose	glucose	NN
cord-022353-q2k2krnm	367	9	,	,	,
cord-022353-q2k2krnm	367	10	adipokines	adipokine	NNS
cord-022353-q2k2krnm	367	11	,	,	,
cord-022353-q2k2krnm	367	12	insulin	insulin	NN
cord-022353-q2k2krnm	367	13	,	,	,
cord-022353-q2k2krnm	367	14	leptin	leptin	NN
cord-022353-q2k2krnm	367	15	,	,	,
cord-022353-q2k2krnm	367	16	soluble	soluble	JJ
cord-022353-q2k2krnm	367	17	leptin	leptin	NN
cord-022353-q2k2krnm	367	18	receptor	receptor	NN
cord-022353-q2k2krnm	367	19	,	,	,
cord-022353-q2k2krnm	367	20	and	and	CC
cord-022353-q2k2krnm	367	21	SLD-1	SLD-1	NNP
cord-022353-q2k2krnm	367	22	.	.	.
cord-022353-q2k2krnm	368	1	For	for	IN
cord-022353-q2k2krnm	368	2	further	further	JJ
cord-022353-q2k2krnm	368	3	discussion	discussion	NN
cord-022353-q2k2krnm	368	4	of	of	IN
cord-022353-q2k2krnm	368	5	mouse	mouse	NN
cord-022353-q2k2krnm	368	6	models	model	NNS
cord-022353-q2k2krnm	368	7	of	of	IN
cord-022353-q2k2krnm	368	8	obesity	obesity	NN
cord-022353-q2k2krnm	368	9	and	and	CC
cord-022353-q2k2krnm	368	10	diabetes	diabete	NNS
cord-022353-q2k2krnm	368	11	please	please	UH
cord-022353-q2k2krnm	368	12	refer	refer	VB
cord-022353-q2k2krnm	368	13	to	to	IN
cord-022353-q2k2krnm	368	14	Chapter	chapter	NN
cord-022353-q2k2krnm	368	15	19	19	CD
cord-022353-q2k2krnm	368	16	in	in	IN
cord-022353-q2k2krnm	368	17	this	this	DT
cord-022353-q2k2krnm	368	18	text	text	NN
cord-022353-q2k2krnm	368	19	.	.	.
cord-022353-q2k2krnm	369	1	Metabolism	metabolism	NN
cord-022353-q2k2krnm	369	2	and	and	CC
cord-022353-q2k2krnm	369	3	Food	Food	NNP
cord-022353-q2k2krnm	369	4	Intake	Intake	NNP
cord-022353-q2k2krnm	369	5	Insulin	Insulin	NNP
cord-022353-q2k2krnm	369	6	,	,	,
cord-022353-q2k2krnm	369	7	leptin	leptin	NN
cord-022353-q2k2krnm	369	8	,	,	,
cord-022353-q2k2krnm	369	9	amylin	amylin	NN
cord-022353-q2k2krnm	369	10	(	(	-LRB-
cord-022353-q2k2krnm	369	11	also	also	RB
cord-022353-q2k2krnm	369	12	called	call	VBN
cord-022353-q2k2krnm	369	13	islet	islet	NN
cord-022353-q2k2krnm	369	14	amyloid	amyloid	NN
cord-022353-q2k2krnm	369	15	polypeptide	polypeptide	NN
cord-022353-q2k2krnm	369	16	,	,	,
cord-022353-q2k2krnm	369	17	IAPP	IAPP	NNP
cord-022353-q2k2krnm	369	18	)	)	-RRB-
cord-022353-q2k2krnm	369	19	,	,	,
cord-022353-q2k2krnm	369	20	glucagon	glucagon	NN
cord-022353-q2k2krnm	369	21	,	,	,
cord-022353-q2k2krnm	369	22	ghrelin	ghrelin	NN
cord-022353-q2k2krnm	369	23	,	,	,
cord-022353-q2k2krnm	369	24	obestatin	obestatin	NNP
cord-022353-q2k2krnm	369	25	,	,	,
cord-022353-q2k2krnm	369	26	orexin	orexin	NN
cord-022353-q2k2krnm	369	27	A	A	NNP
cord-022353-q2k2krnm	369	28	,	,	,
cord-022353-q2k2krnm	369	29	orexin	orexin	NN
cord-022353-q2k2krnm	369	30	B	b	NN
cord-022353-q2k2krnm	369	31	,	,	,
cord-022353-q2k2krnm	369	32	GH	GH	NNP
cord-022353-q2k2krnm	369	33	,	,	,
cord-022353-q2k2krnm	369	34	and	and	CC
cord-022353-q2k2krnm	369	35	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	369	36	have	have	VBP
cord-022353-q2k2krnm	369	37	been	be	VBN
cord-022353-q2k2krnm	369	38	measured	measure	VBN
cord-022353-q2k2krnm	369	39	in	in	IN
cord-022353-q2k2krnm	369	40	mice	mouse	NNS
cord-022353-q2k2krnm	369	41	,	,	,
cord-022353-q2k2krnm	369	42	and	and	CC
cord-022353-q2k2krnm	369	43	RIA	RIA	NNP
cord-022353-q2k2krnm	369	44	and	and	CC
cord-022353-q2k2krnm	369	45	ELISA	ELISA	NNP
cord-022353-q2k2krnm	369	46	kits	kit	NNS
cord-022353-q2k2krnm	369	47	are	be	VBP
cord-022353-q2k2krnm	369	48	commercially	commercially	RB
cord-022353-q2k2krnm	369	49	available	available	JJ
cord-022353-q2k2krnm	369	50	(	(	-LRB-
cord-022353-q2k2krnm	369	51	see	see	VB
cord-022353-q2k2krnm	369	52	Table	table	NN
cord-022353-q2k2krnm	369	53	6	6	CD
cord-022353-q2k2krnm	369	54	-3	-3	NNP
cord-022353-q2k2krnm	369	55	)	)	-RRB-
cord-022353-q2k2krnm	369	56	.	.	.
cord-022353-q2k2krnm	370	1	In	in	IN
cord-022353-q2k2krnm	370	2	addition	addition	NN
cord-022353-q2k2krnm	370	3	,	,	,
cord-022353-q2k2krnm	370	4	these	these	DT
cord-022353-q2k2krnm	370	5	hormones	hormone	NNS
cord-022353-q2k2krnm	370	6	may	may	MD
cord-022353-q2k2krnm	370	7	be	be	VB
cord-022353-q2k2krnm	370	8	measured	measure	VBN
cord-022353-q2k2krnm	370	9	as	as	IN
cord-022353-q2k2krnm	370	10	part	part	NN
cord-022353-q2k2krnm	370	11	of	of	IN
cord-022353-q2k2krnm	370	12	a	a	DT
cord-022353-q2k2krnm	370	13	multiplex	multiplex	JJ
cord-022353-q2k2krnm	370	14	panel	panel	NN
cord-022353-q2k2krnm	370	15	(	(	-LRB-
cord-022353-q2k2krnm	370	16	see	see	VB
cord-022353-q2k2krnm	370	17	"	"	``
cord-022353-q2k2krnm	370	18	Multiplex	Multiplex	NNP
cord-022353-q2k2krnm	370	19	Technology	Technology	NNP
cord-022353-q2k2krnm	370	20	"	"	''
cord-022353-q2k2krnm	370	21	section	section	NN
cord-022353-q2k2krnm	370	22	)	)	-RRB-
cord-022353-q2k2krnm	370	23	.	.	.
cord-022353-q2k2krnm	371	1	Leptin	leptin	NN
cord-022353-q2k2krnm	371	2	values	value	NNS
cord-022353-q2k2krnm	371	3	in	in	IN
cord-022353-q2k2krnm	371	4	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	371	5	,	,	,
cord-022353-q2k2krnm	371	6	129	129	CD
cord-022353-q2k2krnm	371	7	,	,	,
cord-022353-q2k2krnm	371	8	and	and	CC
cord-022353-q2k2krnm	371	9	FVB	FVB	NNP
cord-022353-q2k2krnm	371	10	/	/	SYM
cord-022353-q2k2krnm	371	11	N	n	CD
cord-022353-q2k2krnm	371	12	strains	strain	NNS
cord-022353-q2k2krnm	371	13	range	range	VBP
cord-022353-q2k2krnm	371	14	from	from	IN
cord-022353-q2k2krnm	371	15	1	1	CD
cord-022353-q2k2krnm	371	16	-	-	SYM
cord-022353-q2k2krnm	371	17	3	3	CD
cord-022353-q2k2krnm	371	18	ng	ng	NN
cord-022353-q2k2krnm	371	19	/	/	SYM
cord-022353-q2k2krnm	371	20	ml	ml	NN
cord-022353-q2k2krnm	372	1	,	,	,
cord-022353-q2k2krnm	372	2	insulin	insulin	NN
cord-022353-q2k2krnm	372	3	values	value	NNS
cord-022353-q2k2krnm	372	4	range	range	VBP
cord-022353-q2k2krnm	372	5	from	from	IN
cord-022353-q2k2krnm	372	6	2.2	2.2	CD
cord-022353-q2k2krnm	372	7	-	-	SYM
cord-022353-q2k2krnm	372	8	5.2	5.2	CD
cord-022353-q2k2krnm	373	1	~t	~t	NFP
cord-022353-q2k2krnm	373	2	IU	IU	NNP
cord-022353-q2k2krnm	373	3	/	/	SYM
cord-022353-q2k2krnm	373	4	ml	ml	NN
cord-022353-q2k2krnm	373	5	,	,	,
cord-022353-q2k2krnm	373	6	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	373	7	levels	level	NNS
cord-022353-q2k2krnm	373	8	range	range	VBP
cord-022353-q2k2krnm	373	9	from	from	IN
cord-022353-q2k2krnm	373	10	5	5	CD
cord-022353-q2k2krnm	373	11	-	-	SYM
cord-022353-q2k2krnm	373	12	40	40	CD
cord-022353-q2k2krnm	373	13	~tg	~tg	NNS
cord-022353-q2k2krnm	373	14	/	/	SYM
cord-022353-q2k2krnm	373	15	dl	dl	NN
cord-022353-q2k2krnm	373	16	,	,	,
cord-022353-q2k2krnm	373	17	and	and	CC
cord-022353-q2k2krnm	373	18	GH	GH	NNP
cord-022353-q2k2krnm	373	19	ranges	range	VBZ
cord-022353-q2k2krnm	373	20	from	from	IN
cord-022353-q2k2krnm	373	21	1	1	CD
cord-022353-q2k2krnm	373	22	-	-	SYM
cord-022353-q2k2krnm	373	23	90	90	CD
cord-022353-q2k2krnm	373	24	~tg	~tg	NNS
cord-022353-q2k2krnm	373	25	/	/	SYM
cord-022353-q2k2krnm	373	26	ml	ml	NN
cord-022353-q2k2krnm	373	27	.	.	.
cord-022353-q2k2krnm	374	1	Epinephrine	epinephrine	NN
cord-022353-q2k2krnm	374	2	is	be	VBZ
cord-022353-q2k2krnm	374	3	measured	measure	VBN
cord-022353-q2k2krnm	374	4	by	by	IN
cord-022353-q2k2krnm	374	5	RIA	RIA	NNP
cord-022353-q2k2krnm	374	6	,	,	,
cord-022353-q2k2krnm	374	7	and	and	CC
cord-022353-q2k2krnm	374	8	the	the	DT
cord-022353-q2k2krnm	374	9	range	range	NN
cord-022353-q2k2krnm	374	10	for	for	IN
cord-022353-q2k2krnm	374	11	mice	mice	NN
cord-022353-q2k2krnm	374	12	is	be	VBZ
cord-022353-q2k2krnm	374	13	0	0	CD
cord-022353-q2k2krnm	374	14	-	-	SYM
cord-022353-q2k2krnm	374	15	200	200	CD
cord-022353-q2k2krnm	374	16	pg	pg	NN
cord-022353-q2k2krnm	374	17	/	/	SYM
cord-022353-q2k2krnm	374	18	dl	dl	NNP
cord-022353-q2k2krnm	374	19	(	(	-LRB-
cord-022353-q2k2krnm	374	20	DePaolo	DePaolo	NNP
cord-022353-q2k2krnm	374	21	and	and	CC
cord-022353-q2k2krnm	374	22	Masoro	Masoro	NNP
cord-022353-q2k2krnm	374	23	1989	1989	CD
cord-022353-q2k2krnm	374	24	)	)	-RRB-
cord-022353-q2k2krnm	374	25	.	.	.
cord-022353-q2k2krnm	375	1	Adipokines	adipokine	NNS
cord-022353-q2k2krnm	375	2	secreted	secrete	VBN
cord-022353-q2k2krnm	375	3	entirely	entirely	RB
cord-022353-q2k2krnm	375	4	by	by	IN
cord-022353-q2k2krnm	375	5	adipose	adipose	JJ
cord-022353-q2k2krnm	375	6	tissue	tissue	NN
cord-022353-q2k2krnm	375	7	include	include	VBP
cord-022353-q2k2krnm	375	8	adiponectin	adiponectin	NN
cord-022353-q2k2krnm	375	9	,	,	,
cord-022353-q2k2krnm	375	10	adipsin	adipsin	NNP
cord-022353-q2k2krnm	375	11	,	,	,
cord-022353-q2k2krnm	375	12	and	and	CC
cord-022353-q2k2krnm	375	13	resistin	resistin	NN
cord-022353-q2k2krnm	375	14	.	.	.
cord-022353-q2k2krnm	376	1	Adiponectin	Adiponectin	NNP
cord-022353-q2k2krnm	376	2	and	and	CC
cord-022353-q2k2krnm	376	3	resistin	resistin	NNS
cord-022353-q2k2krnm	376	4	have	have	VBP
cord-022353-q2k2krnm	376	5	been	be	VBN
cord-022353-q2k2krnm	376	6	measured	measure	VBN
cord-022353-q2k2krnm	376	7	in	in	IN
cord-022353-q2k2krnm	376	8	mouse	mouse	NN
cord-022353-q2k2krnm	376	9	serum	serum	NN
cord-022353-q2k2krnm	376	10	and	and	CC
cord-022353-q2k2krnm	376	11	commercial	commercial	JJ
cord-022353-q2k2krnm	376	12	ELISA	ELISA	NNP
cord-022353-q2k2krnm	376	13	test	test	NN
cord-022353-q2k2krnm	376	14	kits	kit	NNS
cord-022353-q2k2krnm	376	15	are	be	VBP
cord-022353-q2k2krnm	376	16	available	available	JJ
cord-022353-q2k2krnm	376	17	for	for	IN
cord-022353-q2k2krnm	376	18	this	this	DT
cord-022353-q2k2krnm	376	19	species	specie	NNS
cord-022353-q2k2krnm	376	20	.	.	.
cord-022353-q2k2krnm	377	1	A	a	DT
cord-022353-q2k2krnm	377	2	polyclonal	polyclonal	JJ
cord-022353-q2k2krnm	377	3	antibody	antibody	NN
cord-022353-q2k2krnm	377	4	that	that	IN
cord-022353-q2k2krnm	377	5	cross	cross	NN
cord-022353-q2k2krnm	377	6	-	-	VBZ
cord-022353-q2k2krnm	377	7	reacts	react	VBZ
cord-022353-q2k2krnm	377	8	with	with	IN
cord-022353-q2k2krnm	377	9	a	a	DT
cord-022353-q2k2krnm	377	10	conserved	conserved	JJ
cord-022353-q2k2krnm	377	11	sequence	sequence	NN
cord-022353-q2k2krnm	377	12	of	of	IN
cord-022353-q2k2krnm	377	13	mouse	mouse	NN
cord-022353-q2k2krnm	377	14	adipsin	adipsin	NNP
cord-022353-q2k2krnm	377	15	has	have	VBZ
cord-022353-q2k2krnm	377	16	been	be	VBN
cord-022353-q2k2krnm	377	17	created	create	VBN
cord-022353-q2k2krnm	377	18	(	(	-LRB-
cord-022353-q2k2krnm	377	19	Searfoss	Searfoss	NNP
cord-022353-q2k2krnm	377	20	et	et	FW
cord-022353-q2k2krnm	377	21	al	al	NNP
cord-022353-q2k2krnm	377	22	.	.	NNP
cord-022353-q2k2krnm	377	23	2003	2003	CD
cord-022353-q2k2krnm	377	24	)	)	-RRB-
cord-022353-q2k2krnm	377	25	.	.	.
cord-022353-q2k2krnm	378	1	TNF	TNF	NNP
cord-022353-q2k2krnm	378	2	-	-	HYPH
cord-022353-q2k2krnm	378	3	ct	ct	NNP
cord-022353-q2k2krnm	378	4	,	,	,
cord-022353-q2k2krnm	378	5	IL-6	IL-6	NNP
cord-022353-q2k2krnm	378	6	,	,	,
cord-022353-q2k2krnm	378	7	and	and	CC
cord-022353-q2k2krnm	378	8	visfatin	visfatin	NNP
cord-022353-q2k2krnm	378	9	are	be	VBP
cord-022353-q2k2krnm	378	10	adipokines	adipokine	NNS
cord-022353-q2k2krnm	378	11	that	that	WDT
cord-022353-q2k2krnm	378	12	are	be	VBP
cord-022353-q2k2krnm	378	13	synthesized	synthesize	VBN
cord-022353-q2k2krnm	378	14	also	also	RB
cord-022353-q2k2krnm	378	15	by	by	IN
cord-022353-q2k2krnm	378	16	macrophages	macrophage	NNS
cord-022353-q2k2krnm	378	17	and	and	CC
cord-022353-q2k2krnm	378	18	lymphocytes	lymphocyte	NNS
cord-022353-q2k2krnm	378	19	;	;	:
cord-022353-q2k2krnm	378	20	as	as	IN
cord-022353-q2k2krnm	378	21	such	such	JJ
cord-022353-q2k2krnm	378	22	they	-PRON-	PRP
cord-022353-q2k2krnm	378	23	provide	provide	VBP
cord-022353-q2k2krnm	378	24	a	a	DT
cord-022353-q2k2krnm	378	25	common	common	JJ
cord-022353-q2k2krnm	378	26	link	link	NN
cord-022353-q2k2krnm	378	27	between	between	IN
cord-022353-q2k2krnm	378	28	regulation	regulation	NN
cord-022353-q2k2krnm	378	29	of	of	IN
cord-022353-q2k2krnm	378	30	obesity	obesity	NN
cord-022353-q2k2krnm	378	31	,	,	,
cord-022353-q2k2krnm	378	32	resistance	resistance	NN
cord-022353-q2k2krnm	378	33	to	to	IN
cord-022353-q2k2krnm	378	34	insulin	insulin	NN
cord-022353-q2k2krnm	378	35	and	and	CC
cord-022353-q2k2krnm	378	36	inflammation	inflammation	NN
cord-022353-q2k2krnm	378	37	(	(	-LRB-
cord-022353-q2k2krnm	378	38	Lazar	Lazar	NNP
cord-022353-q2k2krnm	378	39	2005	2005	CD
cord-022353-q2k2krnm	378	40	)	)	-RRB-
cord-022353-q2k2krnm	378	41	.	.	.
cord-022353-q2k2krnm	379	1	Both	both	DT
cord-022353-q2k2krnm	379	2	TNF	TNF	NNP
cord-022353-q2k2krnm	379	3	-	-	HYPH
cord-022353-q2k2krnm	379	4	t~	t~	NNP
cord-022353-q2k2krnm	380	1	and	and	CC
cord-022353-q2k2krnm	380	2	IL-6	IL-6	NNP
cord-022353-q2k2krnm	380	3	may	may	MD
cord-022353-q2k2krnm	380	4	be	be	VB
cord-022353-q2k2krnm	380	5	measured	measure	VBN
cord-022353-q2k2krnm	380	6	by	by	IN
cord-022353-q2k2krnm	380	7	commercially	commercially	RB
cord-022353-q2k2krnm	380	8	available	available	JJ
cord-022353-q2k2krnm	380	9	ELISA	ELISA	NNP
cord-022353-q2k2krnm	380	10	kits	kit	NNS
cord-022353-q2k2krnm	380	11	(	(	-LRB-
cord-022353-q2k2krnm	380	12	see	see	VB
cord-022353-q2k2krnm	380	13	the	the	DT
cord-022353-q2k2krnm	380	14	"	"	``
cord-022353-q2k2krnm	380	15	Cytokines	Cytokines	NNPS
cord-022353-q2k2krnm	380	16	and	and	CC
cord-022353-q2k2krnm	380	17	Chemokines	Chemokines	NNPS
cord-022353-q2k2krnm	380	18	"	"	''
cord-022353-q2k2krnm	380	19	section	section	NN
cord-022353-q2k2krnm	380	20	)	)	-RRB-
cord-022353-q2k2krnm	380	21	.	.	.
cord-022353-q2k2krnm	381	1	A	a	DT
cord-022353-q2k2krnm	381	2	method	method	NN
cord-022353-q2k2krnm	381	3	has	have	VBZ
cord-022353-q2k2krnm	381	4	also	also	RB
cord-022353-q2k2krnm	381	5	been	be	VBN
cord-022353-q2k2krnm	381	6	published	publish	VBN
cord-022353-q2k2krnm	381	7	for	for	IN
cord-022353-q2k2krnm	381	8	measurement	measurement	NN
cord-022353-q2k2krnm	381	9	of	of	IN
cord-022353-q2k2krnm	381	10	visfatin	visfatin	NNP
cord-022353-q2k2krnm	382	1	(	(	-LRB-
cord-022353-q2k2krnm	382	2	Fukuhara	Fukuhara	NNP
cord-022353-q2k2krnm	382	3	et	et	FW
cord-022353-q2k2krnm	382	4	al	al	NNP
cord-022353-q2k2krnm	382	5	.	.	NNP
cord-022353-q2k2krnm	382	6	2005	2005	CD
cord-022353-q2k2krnm	382	7	)	)	-RRB-
cord-022353-q2k2krnm	382	8	.	.	.
cord-022353-q2k2krnm	383	1	Reagents	reagent	NNS
cord-022353-q2k2krnm	383	2	for	for	IN
cord-022353-q2k2krnm	383	3	quantifying	quantify	VBG
cord-022353-q2k2krnm	383	4	the	the	DT
cord-022353-q2k2krnm	383	5	soluble	soluble	JJ
cord-022353-q2k2krnm	383	6	leptin	leptin	NN
cord-022353-q2k2krnm	383	7	receptor	receptor	NN
cord-022353-q2k2krnm	383	8	and	and	CC
cord-022353-q2k2krnm	383	9	SDL-1	SDL-1	NNP
cord-022353-q2k2krnm	383	10	are	be	VBP
cord-022353-q2k2krnm	383	11	not	not	RB
cord-022353-q2k2krnm	383	12	commercially	commercially	RB
cord-022353-q2k2krnm	383	13	available	available	JJ
cord-022353-q2k2krnm	383	14	at	at	IN
cord-022353-q2k2krnm	383	15	this	this	DT
cord-022353-q2k2krnm	383	16	time	time	NN
cord-022353-q2k2krnm	383	17	,	,	,
cord-022353-q2k2krnm	383	18	although	although	IN
cord-022353-q2k2krnm	383	19	methods	method	NNS
cord-022353-q2k2krnm	383	20	for	for	IN
cord-022353-q2k2krnm	383	21	measurement	measurement	NN
cord-022353-q2k2krnm	383	22	of	of	IN
cord-022353-q2k2krnm	383	23	these	these	DT
cord-022353-q2k2krnm	383	24	analytes	analyte	NNS
cord-022353-q2k2krnm	383	25	in	in	IN
cord-022353-q2k2krnm	383	26	mouse	mouse	NN
cord-022353-q2k2krnm	383	27	serum	serum	NN
cord-022353-q2k2krnm	383	28	have	have	VBP
cord-022353-q2k2krnm	383	29	been	be	VBN
cord-022353-q2k2krnm	383	30	published	publish	VBN
cord-022353-q2k2krnm	384	1	(	(	-LRB-
cord-022353-q2k2krnm	384	2	Cohen	Cohen	NNP
cord-022353-q2k2krnm	384	3	et	et	NNP
cord-022353-q2k2krnm	384	4	al	al	NNP
cord-022353-q2k2krnm	384	5	.	.	.
cord-022353-q2k2krnm	384	6	2002	2002	CD
cord-022353-q2k2krnm	385	1	;	;	:
cord-022353-q2k2krnm	385	2	Cohen	Cohen	NNP
cord-022353-q2k2krnm	385	3	et	et	NNP
cord-022353-q2k2krnm	385	4	al	al	NNP
cord-022353-q2k2krnm	385	5	.	.	NNP
cord-022353-q2k2krnm	385	6	2005	2005	CD
cord-022353-q2k2krnm	385	7	)	)	-RRB-
cord-022353-q2k2krnm	385	8	.	.	.
cord-022353-q2k2krnm	386	1	The	the	DT
cord-022353-q2k2krnm	386	2	four	four	CD
cord-022353-q2k2krnm	386	3	main	main	JJ
cord-022353-q2k2krnm	386	4	types	type	NNS
cord-022353-q2k2krnm	386	5	of	of	IN
cord-022353-q2k2krnm	386	6	lipids	lipid	NNS
cord-022353-q2k2krnm	386	7	in	in	IN
cord-022353-q2k2krnm	386	8	plasma	plasma	NN
cord-022353-q2k2krnm	386	9	are	be	VBP
cord-022353-q2k2krnm	386	10	free	free	JJ
cord-022353-q2k2krnm	386	11	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	386	12	,	,	,
cord-022353-q2k2krnm	386	13	esterified	esterified	JJ
cord-022353-q2k2krnm	386	14	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	386	15	,	,	,
cord-022353-q2k2krnm	386	16	triglycerides	triglyceride	NNS
cord-022353-q2k2krnm	386	17	,	,	,
cord-022353-q2k2krnm	386	18	and	and	CC
cord-022353-q2k2krnm	386	19	phospholipids	phospholipid	NNS
cord-022353-q2k2krnm	386	20	.	.	.
cord-022353-q2k2krnm	387	1	Lipids	lipid	NNS
cord-022353-q2k2krnm	387	2	are	be	VBP
cord-022353-q2k2krnm	387	3	derived	derive	VBN
cord-022353-q2k2krnm	387	4	from	from	IN
cord-022353-q2k2krnm	387	5	the	the	DT
cord-022353-q2k2krnm	387	6	diet	diet	NN
cord-022353-q2k2krnm	387	7	(	(	-LRB-
cord-022353-q2k2krnm	387	8	mainly	mainly	RB
cord-022353-q2k2krnm	387	9	from	from	IN
cord-022353-q2k2krnm	387	10	long	long	JJ
cord-022353-q2k2krnm	387	11	-	-	HYPH
cord-022353-q2k2krnm	387	12	chain	chain	NN
cord-022353-q2k2krnm	387	13	fatty	fatty	JJ
cord-022353-q2k2krnm	387	14	acids	acid	NNS
cord-022353-q2k2krnm	387	15	)	)	-RRB-
cord-022353-q2k2krnm	387	16	,	,	,
cord-022353-q2k2krnm	387	17	although	although	IN
cord-022353-q2k2krnm	387	18	endogenous	endogenous	JJ
cord-022353-q2k2krnm	387	19	recycling	recycling	NN
cord-022353-q2k2krnm	387	20	(	(	-LRB-
cord-022353-q2k2krnm	387	21	mainly	mainly	RB
cord-022353-q2k2krnm	387	22	in	in	IN
cord-022353-q2k2krnm	387	23	the	the	DT
cord-022353-q2k2krnm	387	24	liver	liver	NN
cord-022353-q2k2krnm	387	25	)	)	-RRB-
cord-022353-q2k2krnm	387	26	occurs	occur	VBZ
cord-022353-q2k2krnm	387	27	.	.	.
cord-022353-q2k2krnm	388	1	Plasma	plasma	NN
cord-022353-q2k2krnm	388	2	lipids	lipid	NNS
cord-022353-q2k2krnm	388	3	have	have	VBP
cord-022353-q2k2krnm	388	4	poor	poor	JJ
cord-022353-q2k2krnm	388	5	water	water	NN
cord-022353-q2k2krnm	388	6	solubility	solubility	NN
cord-022353-q2k2krnm	388	7	;	;	:
cord-022353-q2k2krnm	388	8	thus	thus	RB
cord-022353-q2k2krnm	388	9	,	,	,
cord-022353-q2k2krnm	388	10	they	-PRON-	PRP
cord-022353-q2k2krnm	388	11	require	require	VBP
cord-022353-q2k2krnm	388	12	water	water	NN
cord-022353-q2k2krnm	388	13	-	-	HYPH
cord-022353-q2k2krnm	388	14	soluble	soluble	JJ
cord-022353-q2k2krnm	388	15	protein	protein	NN
cord-022353-q2k2krnm	388	16	molecules	molecule	NNS
cord-022353-q2k2krnm	388	17	for	for	IN
cord-022353-q2k2krnm	388	18	their	-PRON-	PRP$
cord-022353-q2k2krnm	388	19	transport	transport	NN
cord-022353-q2k2krnm	388	20	in	in	IN
cord-022353-q2k2krnm	388	21	plasma	plasma	NN
cord-022353-q2k2krnm	388	22	.	.	.
cord-022353-q2k2krnm	389	1	The	the	DT
cord-022353-q2k2krnm	389	2	complex	complex	NN
cord-022353-q2k2krnm	389	3	of	of	IN
cord-022353-q2k2krnm	389	4	plasma	plasma	NN
cord-022353-q2k2krnm	389	5	lipids	lipid	NNS
cord-022353-q2k2krnm	389	6	and	and	CC
cord-022353-q2k2krnm	389	7	proteins	protein	NNS
cord-022353-q2k2krnm	389	8	are	be	VBP
cord-022353-q2k2krnm	389	9	known	know	VBN
cord-022353-q2k2krnm	389	10	as	as	IN
cord-022353-q2k2krnm	389	11	apoproteins	apoprotein	NNS
cord-022353-q2k2krnm	389	12	(	(	-LRB-
cord-022353-q2k2krnm	389	13	also	also	RB
cord-022353-q2k2krnm	389	14	known	know	VBN
cord-022353-q2k2krnm	389	15	as	as	IN
cord-022353-q2k2krnm	389	16	apolipoproteins	apolipoproteins	NNP
cord-022353-q2k2krnm	389	17	)	)	-RRB-
cord-022353-q2k2krnm	389	18	,	,	,
cord-022353-q2k2krnm	389	19	which	which	WDT
cord-022353-q2k2krnm	389	20	contain	contain	VBP
cord-022353-q2k2krnm	389	21	a	a	DT
cord-022353-q2k2krnm	389	22	core	core	NN
cord-022353-q2k2krnm	389	23	of	of	IN
cord-022353-q2k2krnm	389	24	nonpolar	nonpolar	JJ
cord-022353-q2k2krnm	389	25	lipids	lipid	NNS
cord-022353-q2k2krnm	389	26	surrounded	surround	VBN
cord-022353-q2k2krnm	389	27	by	by	IN
cord-022353-q2k2krnm	389	28	a	a	DT
cord-022353-q2k2krnm	389	29	surface	surface	NN
cord-022353-q2k2krnm	389	30	layer	layer	NN
cord-022353-q2k2krnm	389	31	of	of	IN
cord-022353-q2k2krnm	389	32	phospholipids	phospholipid	NNS
cord-022353-q2k2krnm	389	33	,	,	,
cord-022353-q2k2krnm	389	34	free	free	JJ
cord-022353-q2k2krnm	389	35	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	389	36	,	,	,
cord-022353-q2k2krnm	389	37	and	and	CC
cord-022353-q2k2krnm	389	38	apoproteins	apoprotein	NNS
cord-022353-q2k2krnm	389	39	.	.	.
cord-022353-q2k2krnm	390	1	Apoproteins	apoprotein	NNS
cord-022353-q2k2krnm	390	2	are	be	VBP
cord-022353-q2k2krnm	390	3	classified	classify	VBN
cord-022353-q2k2krnm	390	4	according	accord	VBG
cord-022353-q2k2krnm	390	5	to	to	IN
cord-022353-q2k2krnm	390	6	physical	physical	JJ
cord-022353-q2k2krnm	390	7	and	and	CC
cord-022353-q2k2krnm	390	8	chemical	chemical	JJ
cord-022353-q2k2krnm	390	9	parameters	parameter	NNS
cord-022353-q2k2krnm	390	10	,	,	,
cord-022353-q2k2krnm	390	11	and	and	CC
cord-022353-q2k2krnm	390	12	include	include	VBP
cord-022353-q2k2krnm	390	13	(	(	-LRB-
cord-022353-q2k2krnm	390	14	in	in	IN
cord-022353-q2k2krnm	390	15	order	order	NN
cord-022353-q2k2krnm	390	16	of	of	IN
cord-022353-q2k2krnm	390	17	increasing	increase	VBG
cord-022353-q2k2krnm	390	18	density	density	NN
cord-022353-q2k2krnm	390	19	)	)	-RRB-
cord-022353-q2k2krnm	390	20	chylomicrons	chylomicron	NNS
cord-022353-q2k2krnm	390	21	,	,	,
cord-022353-q2k2krnm	390	22	very	very	RB
cord-022353-q2k2krnm	390	23	low	low	JJ
cord-022353-q2k2krnm	390	24	-	-	HYPH
cord-022353-q2k2krnm	390	25	density	density	NN
cord-022353-q2k2krnm	390	26	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	390	27	(	(	-LRB-
cord-022353-q2k2krnm	390	28	VLDL	VLDL	NNP
cord-022353-q2k2krnm	390	29	)	)	-RRB-
cord-022353-q2k2krnm	390	30	,	,	,
cord-022353-q2k2krnm	390	31	intermediate	intermediate	JJ
cord-022353-q2k2krnm	390	32	density	density	NN
cord-022353-q2k2krnm	390	33	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	390	34	(	(	-LRB-
cord-022353-q2k2krnm	390	35	IDL	IDL	NNP
cord-022353-q2k2krnm	390	36	)	)	-RRB-
cord-022353-q2k2krnm	390	37	,	,	,
cord-022353-q2k2krnm	390	38	low	low	JJ
cord-022353-q2k2krnm	390	39	-	-	HYPH
cord-022353-q2k2krnm	390	40	density	density	NN
cord-022353-q2k2krnm	390	41	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	390	42	(	(	-LRB-
cord-022353-q2k2krnm	390	43	LDL	LDL	NNP
cord-022353-q2k2krnm	390	44	)	)	-RRB-
cord-022353-q2k2krnm	390	45	,	,	,
cord-022353-q2k2krnm	390	46	and	and	CC
cord-022353-q2k2krnm	390	47	high	high	JJ
cord-022353-q2k2krnm	390	48	-	-	HYPH
cord-022353-q2k2krnm	390	49	density	density	NN
cord-022353-q2k2krnm	390	50	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	390	51	(	(	-LRB-
cord-022353-q2k2krnm	390	52	HDL	HDL	NNP
cord-022353-q2k2krnm	390	53	)	)	-RRB-
cord-022353-q2k2krnm	390	54	.	.	.
cord-022353-q2k2krnm	391	1	Particle	particle	NN
cord-022353-q2k2krnm	391	2	density	density	NN
cord-022353-q2k2krnm	391	3	is	be	VBZ
cord-022353-q2k2krnm	391	4	proportionally	proportionally	RB
cord-022353-q2k2krnm	391	5	related	relate	VBN
cord-022353-q2k2krnm	391	6	to	to	IN
cord-022353-q2k2krnm	391	7	the	the	DT
cord-022353-q2k2krnm	391	8	amounts	amount	NNS
cord-022353-q2k2krnm	391	9	of	of	IN
cord-022353-q2k2krnm	391	10	phospholipid	phospholipid	NN
cord-022353-q2k2krnm	391	11	,	,	,
cord-022353-q2k2krnm	391	12	protein	protein	NN
cord-022353-q2k2krnm	391	13	,	,	,
cord-022353-q2k2krnm	391	14	and	and	CC
cord-022353-q2k2krnm	391	15	triglycerides	triglyceride	NNS
cord-022353-q2k2krnm	391	16	they	-PRON-	PRP
cord-022353-q2k2krnm	391	17	contain	contain	VBP
cord-022353-q2k2krnm	391	18	;	;	:
cord-022353-q2k2krnm	391	19	increasing	increase	VBG
cord-022353-q2k2krnm	391	20	particle	particle	NN
cord-022353-q2k2krnm	391	21	density	density	NN
cord-022353-q2k2krnm	391	22	corresponds	correspond	VBZ
cord-022353-q2k2krnm	391	23	with	with	IN
cord-022353-q2k2krnm	391	24	increasing	increase	VBG
cord-022353-q2k2krnm	391	25	proportions	proportion	NNS
cord-022353-q2k2krnm	391	26	of	of	IN
cord-022353-q2k2krnm	391	27	phospholipid	phospholipid	NN
cord-022353-q2k2krnm	391	28	and	and	CC
cord-022353-q2k2krnm	391	29	protein	protein	NN
cord-022353-q2k2krnm	391	30	,	,	,
cord-022353-q2k2krnm	391	31	and	and	CC
cord-022353-q2k2krnm	391	32	decreasing	decrease	VBG
cord-022353-q2k2krnm	391	33	density	density	NN
cord-022353-q2k2krnm	391	34	corresponds	correspond	VBZ
cord-022353-q2k2krnm	391	35	with	with	IN
cord-022353-q2k2krnm	391	36	decreasing	decrease	VBG
cord-022353-q2k2krnm	391	37	proportions	proportion	NNS
cord-022353-q2k2krnm	391	38	of	of	IN
cord-022353-q2k2krnm	391	39	triglyceride	triglyceride	NN
cord-022353-q2k2krnm	391	40	.	.	.
cord-022353-q2k2krnm	392	1	Chylomicrons	chylomicron	NNS
cord-022353-q2k2krnm	392	2	and	and	CC
cord-022353-q2k2krnm	392	3	VLDL	VLDL	NNP
cord-022353-q2k2krnm	392	4	are	be	VBP
cord-022353-q2k2krnm	392	5	often	often	RB
cord-022353-q2k2krnm	392	6	referred	refer	VBN
cord-022353-q2k2krnm	392	7	to	to	IN
cord-022353-q2k2krnm	392	8	as	as	IN
cord-022353-q2k2krnm	392	9	triglyceride	triglyceride	NN
cord-022353-q2k2krnm	392	10	-	-	HYPH
cord-022353-q2k2krnm	392	11	rich	rich	JJ
cord-022353-q2k2krnm	392	12	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	392	13	.	.	.
cord-022353-q2k2krnm	393	1	Apoproteins	apoprotein	NNS
cord-022353-q2k2krnm	393	2	on	on	IN
cord-022353-q2k2krnm	393	3	the	the	DT
cord-022353-q2k2krnm	393	4	surface	surface	NN
cord-022353-q2k2krnm	393	5	of	of	IN
cord-022353-q2k2krnm	393	6	the	the	DT
cord-022353-q2k2krnm	393	7	particles	particle	NNS
cord-022353-q2k2krnm	393	8	serve	serve	VBP
cord-022353-q2k2krnm	393	9	as	as	IN
cord-022353-q2k2krnm	393	10	ligands	ligand	NNS
cord-022353-q2k2krnm	393	11	for	for	IN
cord-022353-q2k2krnm	393	12	receptors	receptor	NNS
cord-022353-q2k2krnm	393	13	,	,	,
cord-022353-q2k2krnm	393	14	cofactors	cofactor	NNS
cord-022353-q2k2krnm	393	15	of	of	IN
cord-022353-q2k2krnm	393	16	enzyme	enzyme	NN
cord-022353-q2k2krnm	393	17	interaction	interaction	NN
cord-022353-q2k2krnm	393	18	and	and	CC
cord-022353-q2k2krnm	393	19	structural	structural	JJ
cord-022353-q2k2krnm	393	20	components	component	NNS
cord-022353-q2k2krnm	393	21	(	(	-LRB-
cord-022353-q2k2krnm	393	22	Wagner	Wagner	NNP
cord-022353-q2k2krnm	393	23	et	et	NNP
cord-022353-q2k2krnm	393	24	al	al	NNP
cord-022353-q2k2krnm	393	25	.	.	.
cord-022353-q2k2krnm	393	26	1999	1999	CD
cord-022353-q2k2krnm	393	27	)	)	-RRB-
cord-022353-q2k2krnm	393	28	.	.	.
cord-022353-q2k2krnm	394	1	Table	table	NN
cord-022353-q2k2krnm	394	2	6	6	CD
cord-022353-q2k2krnm	394	3	-5	-5	NNP
cord-022353-q2k2krnm	394	4	lists	list	VBZ
cord-022353-q2k2krnm	394	5	the	the	DT
cord-022353-q2k2krnm	394	6	mouse	mouse	NN
cord-022353-q2k2krnm	394	7	apoproteins	apoprotein	VBZ
cord-022353-q2k2krnm	394	8	and	and	CC
cord-022353-q2k2krnm	394	9	describes	describe	VBZ
cord-022353-q2k2krnm	394	10	their	-PRON-	PRP$
cord-022353-q2k2krnm	394	11	known	know	VBN
cord-022353-q2k2krnm	394	12	function	function	NN
cord-022353-q2k2krnm	394	13	.	.	.
cord-022353-q2k2krnm	395	1	The	the	DT
cord-022353-q2k2krnm	395	2	largest	large	JJS
cord-022353-q2k2krnm	395	3	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	395	4	particle	particle	NN
cord-022353-q2k2krnm	395	5	is	be	VBZ
cord-022353-q2k2krnm	395	6	the	the	DT
cord-022353-q2k2krnm	395	7	chylomicron	chylomicron	NNP
cord-022353-q2k2krnm	395	8	,	,	,
cord-022353-q2k2krnm	395	9	which	which	WDT
cord-022353-q2k2krnm	395	10	transports	transport	VBZ
cord-022353-q2k2krnm	395	11	dietary	dietary	JJ
cord-022353-q2k2krnm	395	12	lipids	lipid	NNS
cord-022353-q2k2krnm	395	13	in	in	IN
cord-022353-q2k2krnm	395	14	the	the	DT
cord-022353-q2k2krnm	395	15	form	form	NN
cord-022353-q2k2krnm	395	16	of	of	IN
cord-022353-q2k2krnm	395	17	triglycerides	triglyceride	NNS
cord-022353-q2k2krnm	395	18	from	from	IN
cord-022353-q2k2krnm	395	19	the	the	DT
cord-022353-q2k2krnm	395	20	intestines	intestine	NNS
cord-022353-q2k2krnm	395	21	.	.	.
cord-022353-q2k2krnm	396	1	Chylomicrons	chylomicron	NNS
cord-022353-q2k2krnm	396	2	contain	contain	VBP
cord-022353-q2k2krnm	396	3	apoproteins	apoprotein	NNS
cord-022353-q2k2krnm	396	4	A	A	NNP
cord-022353-q2k2krnm	396	5	and	and	CC
cord-022353-q2k2krnm	396	6	B48	B48	NNP
cord-022353-q2k2krnm	396	7	and	and	CC
cord-022353-q2k2krnm	396	8	are	be	VBP
cord-022353-q2k2krnm	396	9	absorbed	absorb	VBN
cord-022353-q2k2krnm	396	10	into	into	IN
cord-022353-q2k2krnm	396	11	the	the	DT
cord-022353-q2k2krnm	396	12	lymphatics	lymphatic	NNS
cord-022353-q2k2krnm	396	13	from	from	IN
cord-022353-q2k2krnm	396	14	the	the	DT
cord-022353-q2k2krnm	396	15	intestine	intestine	NN
cord-022353-q2k2krnm	396	16	,	,	,
cord-022353-q2k2krnm	396	17	eventually	eventually	RB
cord-022353-q2k2krnm	396	18	entering	enter	VBG
cord-022353-q2k2krnm	396	19	the	the	DT
cord-022353-q2k2krnm	396	20	blood	blood	NN
cord-022353-q2k2krnm	396	21	.	.	.
cord-022353-q2k2krnm	397	1	They	-PRON-	PRP
cord-022353-q2k2krnm	397	2	deliver	deliver	VBP
cord-022353-q2k2krnm	397	3	fatty	fatty	JJ
cord-022353-q2k2krnm	397	4	acids	acid	NNS
cord-022353-q2k2krnm	397	5	to	to	IN
cord-022353-q2k2krnm	397	6	the	the	DT
cord-022353-q2k2krnm	397	7	tissues	tissue	NNS
cord-022353-q2k2krnm	397	8	with	with	IN
cord-022353-q2k2krnm	397	9	assistance	assistance	NN
cord-022353-q2k2krnm	397	10	from	from	IN
cord-022353-q2k2krnm	397	11	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	397	12	lipase	lipase	NNP
cord-022353-q2k2krnm	397	13	(	(	-LRB-
cord-022353-q2k2krnm	397	14	LPL	LPL	NNP
cord-022353-q2k2krnm	397	15	)	)	-RRB-
cord-022353-q2k2krnm	397	16	and	and	CC
cord-022353-q2k2krnm	397	17	release	release	VB
cord-022353-q2k2krnm	397	18	glycerol	glycerol	NN
cord-022353-q2k2krnm	397	19	into	into	IN
cord-022353-q2k2krnm	397	20	the	the	DT
cord-022353-q2k2krnm	397	21	blood	blood	NN
cord-022353-q2k2krnm	397	22	.	.	.
cord-022353-q2k2krnm	398	1	As	as	IN
cord-022353-q2k2krnm	398	2	chylomicrons	chylomicron	NNS
cord-022353-q2k2krnm	398	3	lose	lose	VBP
cord-022353-q2k2krnm	398	4	triglycerides	triglyceride	NNS
cord-022353-q2k2krnm	398	5	they	-PRON-	PRP
cord-022353-q2k2krnm	398	6	become	become	VBP
cord-022353-q2k2krnm	398	7	smaller	small	JJR
cord-022353-q2k2krnm	398	8	and	and	CC
cord-022353-q2k2krnm	398	9	are	be	VBP
cord-022353-q2k2krnm	398	10	called	call	VBN
cord-022353-q2k2krnm	398	11	remnants	remnant	NNS
cord-022353-q2k2krnm	398	12	.	.	.
cord-022353-q2k2krnm	399	1	These	these	DT
cord-022353-q2k2krnm	399	2	remnants	remnant	NNS
cord-022353-q2k2krnm	399	3	acquire	acquire	VBP
cord-022353-q2k2krnm	399	4	apoprotein	apoprotein	NN
cord-022353-q2k2krnm	399	5	E	E	NNP
cord-022353-q2k2krnm	399	6	from	from	IN
cord-022353-q2k2krnm	399	7	plasma	plasma	NN
cord-022353-q2k2krnm	399	8	HDL	HDL	NNP
cord-022353-q2k2krnm	399	9	and	and	CC
cord-022353-q2k2krnm	399	10	are	be	VBP
cord-022353-q2k2krnm	399	11	rapidly	rapidly	RB
cord-022353-q2k2krnm	399	12	cleared	clear	VBN
cord-022353-q2k2krnm	399	13	by	by	IN
cord-022353-q2k2krnm	399	14	the	the	DT
cord-022353-q2k2krnm	399	15	liver	liver	NN
cord-022353-q2k2krnm	399	16	by	by	IN
cord-022353-q2k2krnm	399	17	the	the	DT
cord-022353-q2k2krnm	399	18	apoprotein	apoprotein	NNP
cord-022353-q2k2krnm	399	19	E	E	NNP
cord-022353-q2k2krnm	399	20	receptor	receptor	NN
cord-022353-q2k2krnm	399	21	or	or	CC
cord-022353-q2k2krnm	399	22	chylomicron	chylomicron	NNP
cord-022353-q2k2krnm	399	23	remnant	remnant	JJ
cord-022353-q2k2krnm	399	24	receptor	receptor	NN
cord-022353-q2k2krnm	399	25	.	.	.
cord-022353-q2k2krnm	400	1	VLDL	VLDL	NNP
cord-022353-q2k2krnm	400	2	is	be	VBZ
cord-022353-q2k2krnm	400	3	the	the	DT
cord-022353-q2k2krnm	400	4	second	second	JJ
cord-022353-q2k2krnm	400	5	most	most	RBS
cord-022353-q2k2krnm	400	6	prevalent	prevalent	JJ
cord-022353-q2k2krnm	400	7	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	400	8	particle	particle	NN
cord-022353-q2k2krnm	400	9	in	in	IN
cord-022353-q2k2krnm	400	10	normal	normal	JJ
cord-022353-q2k2krnm	400	11	mouse	mouse	NN
cord-022353-q2k2krnm	400	12	blood	blood	NN
cord-022353-q2k2krnm	400	13	(	(	-LRB-
cord-022353-q2k2krnm	400	14	after	after	IN
cord-022353-q2k2krnm	400	15	HDL	HDL	NNP
cord-022353-q2k2krnm	400	16	)	)	-RRB-
cord-022353-q2k2krnm	400	17	and	and	CC
cord-022353-q2k2krnm	400	18	it	-PRON-	PRP
cord-022353-q2k2krnm	400	19	transports	transport	VBZ
cord-022353-q2k2krnm	400	20	triglyceride	triglyceride	NN
cord-022353-q2k2krnm	400	21	from	from	IN
cord-022353-q2k2krnm	400	22	liver	liver	NN
cord-022353-q2k2krnm	400	23	to	to	IN
cord-022353-q2k2krnm	400	24	extrahepatic	extrahepatic	JJ
cord-022353-q2k2krnm	400	25	tissues	tissue	NNS
cord-022353-q2k2krnm	400	26	.	.	.
cord-022353-q2k2krnm	401	1	VLDL	VLDL	NNP
cord-022353-q2k2krnm	401	2	is	be	VBZ
cord-022353-q2k2krnm	401	3	synthesized	synthesize	VBN
cord-022353-q2k2krnm	401	4	in	in	IN
cord-022353-q2k2krnm	401	5	the	the	DT
cord-022353-q2k2krnm	401	6	liver	liver	NN
cord-022353-q2k2krnm	401	7	with	with	IN
cord-022353-q2k2krnm	401	8	apoprotein	apoprotein	NNP
cord-022353-q2k2krnm	401	9	B	B	NNP
cord-022353-q2k2krnm	401	10	100	100	CD
cord-022353-q2k2krnm	401	11	,	,	,
cord-022353-q2k2krnm	401	12	C	C	NNP
cord-022353-q2k2krnm	401	13	,	,	,
cord-022353-q2k2krnm	401	14	and	and	CC
cord-022353-q2k2krnm	401	15	E	E	NNP
cord-022353-q2k2krnm	401	16	attached	attach	VBN
cord-022353-q2k2krnm	401	17	.	.	.
cord-022353-q2k2krnm	402	1	LPL	LPL	NNP
cord-022353-q2k2krnm	402	2	aids	aids	NNP
cord-022353-q2k2krnm	402	3	in	in	IN
cord-022353-q2k2krnm	402	4	the	the	DT
cord-022353-q2k2krnm	402	5	release	release	NN
cord-022353-q2k2krnm	402	6	of	of	IN
cord-022353-q2k2krnm	402	7	fatty	fatty	JJ
cord-022353-q2k2krnm	402	8	acids	acid	NNS
cord-022353-q2k2krnm	402	9	(	(	-LRB-
cord-022353-q2k2krnm	402	10	from	from	IN
cord-022353-q2k2krnm	402	11	triglycerides	triglyceride	NNS
cord-022353-q2k2krnm	402	12	)	)	-RRB-
cord-022353-q2k2krnm	402	13	to	to	IN
cord-022353-q2k2krnm	402	14	peripheral	peripheral	JJ
cord-022353-q2k2krnm	402	15	tissues	tissue	NNS
cord-022353-q2k2krnm	402	16	.	.	.
cord-022353-q2k2krnm	403	1	LDL	LDL	NNP
cord-022353-q2k2krnm	403	2	,	,	,
cord-022353-q2k2krnm	403	3	which	which	WDT
cord-022353-q2k2krnm	403	4	is	be	VBZ
cord-022353-q2k2krnm	403	5	present	present	JJ
cord-022353-q2k2krnm	403	6	in	in	IN
cord-022353-q2k2krnm	403	7	very	very	RB
cord-022353-q2k2krnm	403	8	low	low	JJ
cord-022353-q2k2krnm	403	9	concentrations	concentration	NNS
cord-022353-q2k2krnm	403	10	in	in	IN
cord-022353-q2k2krnm	403	11	normal	normal	JJ
cord-022353-q2k2krnm	403	12	mice	mouse	NNS
cord-022353-q2k2krnm	403	13	,	,	,
cord-022353-q2k2krnm	403	14	carries	carry	VBZ
cord-022353-q2k2krnm	403	15	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	403	16	to	to	IN
cord-022353-q2k2krnm	403	17	extrahepatic	extrahepatic	JJ
cord-022353-q2k2krnm	403	18	tissues	tissue	NNS
cord-022353-q2k2krnm	403	19	.	.	.
cord-022353-q2k2krnm	404	1	LDL	ldl	NN
cord-022353-q2k2krnm	404	2	contains	contain	VBZ
cord-022353-q2k2krnm	404	3	Apoprotein	Apoprotein	NNP
cord-022353-q2k2krnm	404	4	B	B	NNP
cord-022353-q2k2krnm	404	5	100	100	CD
cord-022353-q2k2krnm	404	6	and	and	CC
cord-022353-q2k2krnm	404	7	is	be	VBZ
cord-022353-q2k2krnm	404	8	the	the	DT
cord-022353-q2k2krnm	404	9	primary	primary	JJ
cord-022353-q2k2krnm	404	10	source	source	NN
cord-022353-q2k2krnm	404	11	of	of	IN
cord-022353-q2k2krnm	404	12	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	404	13	deposited	deposit	VBN
cord-022353-q2k2krnm	404	14	in	in	IN
cord-022353-q2k2krnm	404	15	the	the	DT
cord-022353-q2k2krnm	404	16	intima	intima	NN
cord-022353-q2k2krnm	404	17	of	of	IN
cord-022353-q2k2krnm	404	18	arteries	artery	NNS
cord-022353-q2k2krnm	404	19	in	in	IN
cord-022353-q2k2krnm	404	20	mice	mouse	NNS
cord-022353-q2k2krnm	404	21	.	.	.
cord-022353-q2k2krnm	405	1	Apoprotein	Apoprotein	NNP
cord-022353-q2k2krnm	405	2	B	B	NNP
cord-022353-q2k2krnm	405	3	100	100	CD
cord-022353-q2k2krnm	405	4	binds	bind	VBZ
cord-022353-q2k2krnm	405	5	to	to	IN
cord-022353-q2k2krnm	405	6	the	the	DT
cord-022353-q2k2krnm	405	7	LDL	LDL	NNP
cord-022353-q2k2krnm	405	8	receptor	receptor	NN
cord-022353-q2k2krnm	405	9	(	(	-LRB-
cord-022353-q2k2krnm	405	10	LDLR	LDLR	NNP
cord-022353-q2k2krnm	405	11	)	)	-RRB-
cord-022353-q2k2krnm	405	12	.	.	.
cord-022353-q2k2krnm	406	1	HDL	HDL	NNP
cord-022353-q2k2krnm	406	2	is	be	VBZ
cord-022353-q2k2krnm	406	3	synthesized	synthesize	VBN
cord-022353-q2k2krnm	406	4	in	in	IN
cord-022353-q2k2krnm	406	5	the	the	DT
cord-022353-q2k2krnm	406	6	liver	liver	NN
cord-022353-q2k2krnm	406	7	and	and	CC
cord-022353-q2k2krnm	406	8	contains	contain	VBZ
cord-022353-q2k2krnm	406	9	large	large	JJ
cord-022353-q2k2krnm	406	10	amounts	amount	NNS
cord-022353-q2k2krnm	406	11	of	of	IN
cord-022353-q2k2krnm	406	12	free	free	JJ
cord-022353-q2k2krnm	406	13	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	406	14	and	and	CC
cord-022353-q2k2krnm	406	15	apoproteins	apoprotein	VBZ
cord-022353-q2k2krnm	406	16	A	A	NNP
cord-022353-q2k2krnm	406	17	,	,	,
cord-022353-q2k2krnm	406	18	C	C	NNP
cord-022353-q2k2krnm	406	19	,	,	,
cord-022353-q2k2krnm	406	20	and	and	CC
cord-022353-q2k2krnm	406	21	E.	E.	NNP
cord-022353-q2k2krnm	407	1	During	during	IN
cord-022353-q2k2krnm	407	2	metabolism	metabolism	NN
cord-022353-q2k2krnm	407	3	HDL	HDL	NNP
cord-022353-q2k2krnm	407	4	free	free	JJ
cord-022353-q2k2krnm	407	5	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	407	6	is	be	VBZ
cord-022353-q2k2krnm	407	7	esterified	esterify	VBN
cord-022353-q2k2krnm	407	8	by	by	IN
cord-022353-q2k2krnm	407	9	the	the	DT
cord-022353-q2k2krnm	407	10	action	action	NN
cord-022353-q2k2krnm	407	11	of	of	IN
cord-022353-q2k2krnm	407	12	lecithin	lecithin	NN
cord-022353-q2k2krnm	407	13	:	:	:
cord-022353-q2k2krnm	407	14	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	407	15	acyltransferase	acyltransferase	NN
cord-022353-q2k2krnm	407	16	(	(	-LRB-
cord-022353-q2k2krnm	407	17	LCAT	LCAT	NNP
cord-022353-q2k2krnm	407	18	)	)	-RRB-
cord-022353-q2k2krnm	407	19	.	.	.
cord-022353-q2k2krnm	408	1	The	the	DT
cord-022353-q2k2krnm	408	2	exchange	exchange	NN
cord-022353-q2k2krnm	408	3	of	of	IN
cord-022353-q2k2krnm	408	4	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	408	5	ester	ester	NN
cord-022353-q2k2krnm	408	6	for	for	IN
cord-022353-q2k2krnm	408	7	triglycerides	triglyceride	NNS
cord-022353-q2k2krnm	408	8	(	(	-LRB-
cord-022353-q2k2krnm	408	9	from	from	IN
cord-022353-q2k2krnm	408	10	VLDL	VLDL	NNP
cord-022353-q2k2krnm	408	11	)	)	-RRB-
cord-022353-q2k2krnm	408	12	results	result	VBZ
cord-022353-q2k2krnm	408	13	in	in	IN
cord-022353-q2k2krnm	408	14	a	a	DT
cord-022353-q2k2krnm	408	15	less	less	RBR
cord-022353-q2k2krnm	408	16	dense	dense	JJ
cord-022353-q2k2krnm	408	17	HDL	hdl	NN
cord-022353-q2k2krnm	408	18	subfraction	subfraction	NN
cord-022353-q2k2krnm	408	19	that	that	WDT
cord-022353-q2k2krnm	408	20	is	be	VBZ
cord-022353-q2k2krnm	408	21	completely	completely	RB
cord-022353-q2k2krnm	408	22	removed	remove	VBN
cord-022353-q2k2krnm	408	23	from	from	IN
cord-022353-q2k2krnm	408	24	the	the	DT
cord-022353-q2k2krnm	408	25	circulation	circulation	NN
cord-022353-q2k2krnm	408	26	by	by	IN
cord-022353-q2k2krnm	408	27	the	the	DT
cord-022353-q2k2krnm	408	28	liver	liver	NN
cord-022353-q2k2krnm	408	29	.	.	.
cord-022353-q2k2krnm	409	1	Exchange	exchange	NN
cord-022353-q2k2krnm	409	2	of	of	IN
cord-022353-q2k2krnm	409	3	esterified	esterified	JJ
cord-022353-q2k2krnm	409	4	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	409	5	for	for	IN
cord-022353-q2k2krnm	409	6	triglycerides	triglyceride	NNS
cord-022353-q2k2krnm	409	7	is	be	VBZ
cord-022353-q2k2krnm	409	8	mediated	mediate	VBN
cord-022353-q2k2krnm	409	9	by	by	IN
cord-022353-q2k2krnm	409	10	cholesteryl	cholesteryl	NNP
cord-022353-q2k2krnm	409	11	ester	ester	NNP
cord-022353-q2k2krnm	409	12	transfer	transfer	NN
cord-022353-q2k2krnm	409	13	protein	protein	NN
cord-022353-q2k2krnm	409	14	(	(	-LRB-
cord-022353-q2k2krnm	409	15	CETP	CETP	NNP
cord-022353-q2k2krnm	409	16	)	)	-RRB-
cord-022353-q2k2krnm	409	17	in	in	IN
cord-022353-q2k2krnm	409	18	humans	human	NNS
cord-022353-q2k2krnm	409	19	;	;	:
cord-022353-q2k2krnm	409	20	however	however	RB
cord-022353-q2k2krnm	409	21	,	,	,
cord-022353-q2k2krnm	409	22	this	this	DT
cord-022353-q2k2krnm	409	23	activity	activity	NN
cord-022353-q2k2krnm	409	24	is	be	VBZ
cord-022353-q2k2krnm	409	25	absent	absent	JJ
cord-022353-q2k2krnm	409	26	in	in	IN
cord-022353-q2k2krnm	409	27	mice	mouse	NNS
cord-022353-q2k2krnm	409	28	.	.	.
cord-022353-q2k2krnm	410	1	Phospholipid	phospholipid	NN
cord-022353-q2k2krnm	410	2	transfer	transfer	NN
cord-022353-q2k2krnm	410	3	from	from	IN
cord-022353-q2k2krnm	410	4	VLDL	VLDL	NNP
cord-022353-q2k2krnm	410	5	to	to	IN
cord-022353-q2k2krnm	410	6	HDL	HDL	NNP
cord-022353-q2k2krnm	410	7	is	be	VBZ
cord-022353-q2k2krnm	410	8	mediated	mediate	VBN
cord-022353-q2k2krnm	410	9	by	by	IN
cord-022353-q2k2krnm	410	10	phospholipids	phospholipid	NNS
cord-022353-q2k2krnm	410	11	transfer	transfer	NN
cord-022353-q2k2krnm	410	12	protein	protein	NN
cord-022353-q2k2krnm	410	13	(	(	-LRB-
cord-022353-q2k2krnm	410	14	PLTP	PLTP	NNP
cord-022353-q2k2krnm	410	15	)	)	-RRB-
cord-022353-q2k2krnm	410	16	.	.	.
cord-022353-q2k2krnm	411	1	High	high	JJ
cord-022353-q2k2krnm	411	2	levels	level	NNS
cord-022353-q2k2krnm	411	3	of	of	IN
cord-022353-q2k2krnm	411	4	soluble	soluble	JJ
cord-022353-q2k2krnm	411	5	hepatic	hepatic	JJ
cord-022353-q2k2krnm	411	6	lipase	lipase	NN
cord-022353-q2k2krnm	411	7	are	be	VBP
cord-022353-q2k2krnm	411	8	found	find	VBN
cord-022353-q2k2krnm	411	9	in	in	IN
cord-022353-q2k2krnm	411	10	mouse	mouse	NN
cord-022353-q2k2krnm	411	11	plasma	plasma	NN
cord-022353-q2k2krnm	411	12	(	(	-LRB-
cord-022353-q2k2krnm	411	13	Lusis	Lusis	NNP
cord-022353-q2k2krnm	411	14	,	,	,
cord-022353-q2k2krnm	411	15	2000	2000	CD
cord-022353-q2k2krnm	411	16	;	;	:
cord-022353-q2k2krnm	411	17	Wagner	Wagner	NNP
cord-022353-q2k2krnm	411	18	et	et	NNP
cord-022353-q2k2krnm	411	19	al	al	NNP
cord-022353-q2k2krnm	411	20	.	.	.
cord-022353-q2k2krnm	411	21	1999	1999	CD
cord-022353-q2k2krnm	411	22	)	)	-RRB-
cord-022353-q2k2krnm	411	23	.	.	.
cord-022353-q2k2krnm	412	1	HDL	HDL	NNP
cord-022353-q2k2krnm	412	2	is	be	VBZ
cord-022353-q2k2krnm	412	3	thought	think	VBN
cord-022353-q2k2krnm	412	4	to	to	TO
cord-022353-q2k2krnm	412	5	transport	transport	VB
cord-022353-q2k2krnm	412	6	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	412	7	from	from	IN
cord-022353-q2k2krnm	412	8	peripheral	peripheral	JJ
cord-022353-q2k2krnm	412	9	tissue	tissue	NN
cord-022353-q2k2krnm	412	10	to	to	IN
cord-022353-q2k2krnm	412	11	liver	liver	NN
cord-022353-q2k2krnm	412	12	by	by	IN
cord-022353-q2k2krnm	412	13	a	a	DT
cord-022353-q2k2krnm	412	14	process	process	NN
cord-022353-q2k2krnm	412	15	known	know	VBN
cord-022353-q2k2krnm	412	16	as	as	IN
cord-022353-q2k2krnm	412	17	reverse	reverse	JJ
cord-022353-q2k2krnm	412	18	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	412	19	transport	transport	NN
cord-022353-q2k2krnm	412	20	(	(	-LRB-
cord-022353-q2k2krnm	412	21	RCT	RCT	NNP
cord-022353-q2k2krnm	412	22	)	)	-RRB-
cord-022353-q2k2krnm	412	23	.	.	.
cord-022353-q2k2krnm	413	1	This	this	DT
cord-022353-q2k2krnm	413	2	process	process	NN
cord-022353-q2k2krnm	413	3	is	be	VBZ
cord-022353-q2k2krnm	413	4	believed	believe	VBN
cord-022353-q2k2krnm	413	5	to	to	TO
cord-022353-q2k2krnm	413	6	be	be	VB
cord-022353-q2k2krnm	413	7	facilitated	facilitate	VBN
cord-022353-q2k2krnm	413	8	by	by	IN
cord-022353-q2k2krnm	413	9	the	the	DT
cord-022353-q2k2krnm	413	10	adenosine	adenosine	NN
cord-022353-q2k2krnm	413	11	triphosphate	triphosphate	NN
cord-022353-q2k2krnm	413	12	(	(	-LRB-
cord-022353-q2k2krnm	413	13	ATP)binding	atp)binding	DT
cord-022353-q2k2krnm	413	14	cassette	cassette	NN
cord-022353-q2k2krnm	413	15	transporter	transporter	NN
cord-022353-q2k2krnm	413	16	A1	a1	NN
cord-022353-q2k2krnm	413	17	(	(	-LRB-
cord-022353-q2k2krnm	413	18	ABCA1	ABCA1	NNP
cord-022353-q2k2krnm	413	19	)	)	-RRB-
cord-022353-q2k2krnm	413	20	,	,	,
cord-022353-q2k2krnm	413	21	which	which	WDT
cord-022353-q2k2krnm	413	22	transports	transport	VBZ
cord-022353-q2k2krnm	413	23	phospholipids	phospholipid	NNS
cord-022353-q2k2krnm	413	24	and	and	CC
cord-022353-q2k2krnm	413	25	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	413	26	to	to	IN
cord-022353-q2k2krnm	413	27	the	the	DT
cord-022353-q2k2krnm	413	28	acceptors	acceptor	NNS
cord-022353-q2k2krnm	413	29	apoprotein	apoprotein	VBP
cord-022353-q2k2krnm	413	30	A-1	A-1	NNP
cord-022353-q2k2krnm	413	31	and	and	CC
cord-022353-q2k2krnm	413	32	apoprotein	apoprotein	NNP
cord-022353-q2k2krnm	413	33	E	E	NNP
cord-022353-q2k2krnm	413	34	(	(	-LRB-
cord-022353-q2k2krnm	413	35	Aiello	Aiello	NNP
cord-022353-q2k2krnm	413	36	et	et	NNP
cord-022353-q2k2krnm	413	37	al	al	NNP
cord-022353-q2k2krnm	413	38	.	.	.
cord-022353-q2k2krnm	413	39	2002	2002	CD
cord-022353-q2k2krnm	413	40	)	)	-RRB-
cord-022353-q2k2krnm	413	41	.	.	.
cord-022353-q2k2krnm	414	1	HDL	HDL	NNP
cord-022353-q2k2krnm	414	2	also	also	RB
cord-022353-q2k2krnm	414	3	serves	serve	VBZ
cord-022353-q2k2krnm	414	4	as	as	IN
cord-022353-q2k2krnm	414	5	a	a	DT
cord-022353-q2k2krnm	414	6	reserve	reserve	NN
cord-022353-q2k2krnm	414	7	of	of	IN
cord-022353-q2k2krnm	414	8	apoprotein	apoprotein	NNP
cord-022353-q2k2krnm	414	9	C	C	NNP
cord-022353-q2k2krnm	414	10	and	and	CC
cord-022353-q2k2krnm	414	11	apoprotein	apoprotein	NNP
cord-022353-q2k2krnm	414	12	E	E	NNP
cord-022353-q2k2krnm	414	13	necessary	necessary	JJ
cord-022353-q2k2krnm	414	14	for	for	IN
cord-022353-q2k2krnm	414	15	VLDL	vldl	NN
cord-022353-q2k2krnm	414	16	metabolism	metabolism	NN
cord-022353-q2k2krnm	414	17	.	.	.
cord-022353-q2k2krnm	415	1	Table	table	NN
cord-022353-q2k2krnm	415	2	6	6	CD
cord-022353-q2k2krnm	415	3	-6	-6	NNP
cord-022353-q2k2krnm	415	4	lists	list	VBZ
cord-022353-q2k2krnm	415	5	the	the	DT
cord-022353-q2k2krnm	415	6	apolipoprotein	apolipoprotein	NN
cord-022353-q2k2krnm	415	7	receptors	receptor	NNS
cord-022353-q2k2krnm	415	8	found	find	VBN
cord-022353-q2k2krnm	415	9	in	in	IN
cord-022353-q2k2krnm	415	10	mice	mouse	NNS
cord-022353-q2k2krnm	415	11	and	and	CC
cord-022353-q2k2krnm	415	12	describes	describe	VBZ
cord-022353-q2k2krnm	415	13	their	-PRON-	PRP$
cord-022353-q2k2krnm	415	14	ligands	ligand	NNS
cord-022353-q2k2krnm	415	15	and	and	CC
cord-022353-q2k2krnm	415	16	functions	function	NNS
cord-022353-q2k2krnm	415	17	.	.	.
cord-022353-q2k2krnm	416	1	Atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	416	2	is	be	VBZ
cord-022353-q2k2krnm	416	3	a	a	DT
cord-022353-q2k2krnm	416	4	major	major	JJ
cord-022353-q2k2krnm	416	5	factor	factor	NN
cord-022353-q2k2krnm	416	6	in	in	IN
cord-022353-q2k2krnm	416	7	heart	heart	NN
cord-022353-q2k2krnm	416	8	disease	disease	NN
cord-022353-q2k2krnm	416	9	,	,	,
cord-022353-q2k2krnm	416	10	stroke	stroke	NN
cord-022353-q2k2krnm	416	11	,	,	,
cord-022353-q2k2krnm	416	12	and	and	CC
cord-022353-q2k2krnm	416	13	peripheral	peripheral	JJ
cord-022353-q2k2krnm	416	14	vascular	vascular	JJ
cord-022353-q2k2krnm	416	15	disease	disease	NN
cord-022353-q2k2krnm	416	16	in	in	IN
cord-022353-q2k2krnm	416	17	humans	human	NNS
cord-022353-q2k2krnm	416	18	,	,	,
cord-022353-q2k2krnm	416	19	and	and	CC
cord-022353-q2k2krnm	416	20	as	as	RB
cord-022353-q2k2krnm	416	21	such	such	JJ
cord-022353-q2k2krnm	416	22	,	,	,
cord-022353-q2k2krnm	416	23	is	be	VBZ
cord-022353-q2k2krnm	416	24	the	the	DT
cord-022353-q2k2krnm	416	25	principal	principal	JJ
cord-022353-q2k2krnm	416	26	cause	cause	NN
cord-022353-q2k2krnm	416	27	of	of	IN
cord-022353-q2k2krnm	416	28	death	death	NN
cord-022353-q2k2krnm	416	29	in	in	IN
cord-022353-q2k2krnm	416	30	western	western	JJ
cord-022353-q2k2krnm	416	31	countries	country	NNS
cord-022353-q2k2krnm	416	32	.	.	.
cord-022353-q2k2krnm	417	1	The	the	DT
cord-022353-q2k2krnm	417	2	etiology	etiology	NN
cord-022353-q2k2krnm	417	3	is	be	VBZ
cord-022353-q2k2krnm	417	4	complex	complex	JJ
cord-022353-q2k2krnm	417	5	,	,	,
cord-022353-q2k2krnm	417	6	involving	involve	VBG
cord-022353-q2k2krnm	417	7	both	both	CC
cord-022353-q2k2krnm	417	8	genetic	genetic	JJ
cord-022353-q2k2krnm	417	9	and	and	CC
cord-022353-q2k2krnm	417	10	environmental	environmental	JJ
cord-022353-q2k2krnm	417	11	components	component	NNS
cord-022353-q2k2krnm	417	12	.	.	.
cord-022353-q2k2krnm	418	1	Although	although	IN
cord-022353-q2k2krnm	418	2	there	there	EX
cord-022353-q2k2krnm	418	3	are	be	VBP
cord-022353-q2k2krnm	418	4	some	some	DT
cord-022353-q2k2krnm	418	5	examples	example	NNS
cord-022353-q2k2krnm	418	6	of	of	IN
cord-022353-q2k2krnm	418	7	single	single	JJ
cord-022353-q2k2krnm	418	8	gene	gene	NN
cord-022353-q2k2krnm	418	9	defects	defect	NNS
cord-022353-q2k2krnm	418	10	in	in	IN
cord-022353-q2k2krnm	418	11	humans	human	NNS
cord-022353-q2k2krnm	418	12	that	that	WDT
cord-022353-q2k2krnm	418	13	lead	lead	VBP
cord-022353-q2k2krnm	418	14	to	to	IN
cord-022353-q2k2krnm	418	15	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	418	16	,	,	,
cord-022353-q2k2krnm	418	17	these	these	DT
cord-022353-q2k2krnm	418	18	conditions	condition	NNS
cord-022353-q2k2krnm	418	19	are	be	VBP
cord-022353-q2k2krnm	418	20	rare	rare	JJ
cord-022353-q2k2krnm	418	21	and	and	CC
cord-022353-q2k2krnm	418	22	do	do	VBP
cord-022353-q2k2krnm	418	23	not	not	RB
cord-022353-q2k2krnm	418	24	explain	explain	VB
cord-022353-q2k2krnm	418	25	disease	disease	NN
cord-022353-q2k2krnm	418	26	prevalence	prevalence	NN
cord-022353-q2k2krnm	418	27	.	.	.
cord-022353-q2k2krnm	419	1	Atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	419	2	is	be	VBZ
cord-022353-q2k2krnm	419	3	characterized	characterize	VBN
cord-022353-q2k2krnm	419	4	by	by	IN
cord-022353-q2k2krnm	419	5	the	the	DT
cord-022353-q2k2krnm	419	6	formation	formation	NN
cord-022353-q2k2krnm	419	7	of	of	IN
cord-022353-q2k2krnm	419	8	plaques	plaque	NNS
cord-022353-q2k2krnm	419	9	in	in	IN
cord-022353-q2k2krnm	419	10	the	the	DT
cord-022353-q2k2krnm	419	11	intima	intima	NN
cord-022353-q2k2krnm	419	12	of	of	IN
cord-022353-q2k2krnm	419	13	large	large	JJ
cord-022353-q2k2krnm	419	14	and	and	CC
cord-022353-q2k2krnm	419	15	medium	medium	JJ
cord-022353-q2k2krnm	419	16	size	size	NN
cord-022353-q2k2krnm	419	17	arteries	artery	NNS
cord-022353-q2k2krnm	419	18	,	,	,
cord-022353-q2k2krnm	419	19	usually	usually	RB
cord-022353-q2k2krnm	419	20	in	in	IN
cord-022353-q2k2krnm	419	21	locations	location	NNS
cord-022353-q2k2krnm	419	22	where	where	WRB
cord-022353-q2k2krnm	419	23	blood	blood	NN
cord-022353-q2k2krnm	419	24	flow	flow	NN
cord-022353-q2k2krnm	419	25	is	be	VBZ
cord-022353-q2k2krnm	419	26	disturbed	disturb	VBN
cord-022353-q2k2krnm	419	27	.	.	.
cord-022353-q2k2krnm	420	1	The	the	DT
cord-022353-q2k2krnm	420	2	plaques	plaque	NNS
cord-022353-q2k2krnm	420	3	contain	contain	VBP
cord-022353-q2k2krnm	420	4	a	a	DT
cord-022353-q2k2krnm	420	5	variety	variety	NN
cord-022353-q2k2krnm	420	6	of	of	IN
cord-022353-q2k2krnm	420	7	cells	cell	NNS
cord-022353-q2k2krnm	420	8	including	include	VBG
cord-022353-q2k2krnm	420	9	endothelial	endothelial	JJ
cord-022353-q2k2krnm	420	10	cells	cell	NNS
cord-022353-q2k2krnm	420	11	,	,	,
cord-022353-q2k2krnm	420	12	monocytes	monocyte	NNS
cord-022353-q2k2krnm	420	13	or	or	CC
cord-022353-q2k2krnm	420	14	macrophages	macrophage	NNS
cord-022353-q2k2krnm	420	15	,	,	,
cord-022353-q2k2krnm	420	16	smooth	smooth	JJ
cord-022353-q2k2krnm	420	17	muscle	muscle	NN
cord-022353-q2k2krnm	420	18	cells	cell	NNS
cord-022353-q2k2krnm	420	19	,	,	,
cord-022353-q2k2krnm	420	20	and	and	CC
cord-022353-q2k2krnm	420	21	lymphocytes	lymphocyte	NNS
cord-022353-q2k2krnm	420	22	,	,	,
cord-022353-q2k2krnm	420	23	which	which	WDT
cord-022353-q2k2krnm	420	24	secrete	secrete	VBP
cord-022353-q2k2krnm	420	25	products	product	NNS
cord-022353-q2k2krnm	420	26	that	that	WDT
cord-022353-q2k2krnm	420	27	modulate	modulate	VBP
cord-022353-q2k2krnm	420	28	progression	progression	NN
cord-022353-q2k2krnm	420	29	of	of	IN
cord-022353-q2k2krnm	420	30	plaque	plaque	NN
cord-022353-q2k2krnm	420	31	formation	formation	NN
cord-022353-q2k2krnm	420	32	.	.	.
cord-022353-q2k2krnm	421	1	In	in	IN
cord-022353-q2k2krnm	421	2	addition	addition	NN
cord-022353-q2k2krnm	421	3	plaques	plaque	NNS
cord-022353-q2k2krnm	421	4	contain	contain	VBP
cord-022353-q2k2krnm	421	5	a	a	DT
cord-022353-q2k2krnm	421	6	complex	complex	JJ
cord-022353-q2k2krnm	421	7	mix	mix	NN
cord-022353-q2k2krnm	421	8	of	of	IN
cord-022353-q2k2krnm	421	9	collagen	collagen	NN
cord-022353-q2k2krnm	421	10	,	,	,
cord-022353-q2k2krnm	421	11	proteoglycans	proteoglycan	NNS
cord-022353-q2k2krnm	421	12	,	,	,
cord-022353-q2k2krnm	421	13	occasional	occasional	JJ
cord-022353-q2k2krnm	421	14	cartilaginous	cartilaginous	JJ
cord-022353-q2k2krnm	421	15	tissue	tissue	NN
cord-022353-q2k2krnm	421	16	with	with	IN
cord-022353-q2k2krnm	421	17	calcification	calcification	NN
cord-022353-q2k2krnm	421	18	and	and	CC
cord-022353-q2k2krnm	421	19	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	421	20	(	(	-LRB-
cord-022353-q2k2krnm	421	21	primarily	primarily	RB
cord-022353-q2k2krnm	421	22	LDL	LDL	NNP
cord-022353-q2k2krnm	421	23	)	)	-RRB-
cord-022353-q2k2krnm	421	24	.	.	.
cord-022353-q2k2krnm	422	1	Disease	disease	NN
cord-022353-q2k2krnm	422	2	risk	risk	NN
cord-022353-q2k2krnm	422	3	correlates	correlate	VBZ
cord-022353-q2k2krnm	422	4	directly	directly	RB
cord-022353-q2k2krnm	422	5	with	with	IN
cord-022353-q2k2krnm	422	6	elevated	elevated	JJ
cord-022353-q2k2krnm	422	7	circulating	circulating	JJ
cord-022353-q2k2krnm	422	8	levels	level	NNS
cord-022353-q2k2krnm	422	9	of	of	IN
cord-022353-q2k2krnm	422	10	LDL	ldl	NN
cord-022353-q2k2krnm	422	11	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	422	12	and	and	CC
cord-022353-q2k2krnm	422	13	risk	risk	NN
cord-022353-q2k2krnm	422	14	is	be	VBZ
cord-022353-q2k2krnm	422	15	indirectly	indirectly	RB
cord-022353-q2k2krnm	422	16	correlated	correlate	VBN
cord-022353-q2k2krnm	422	17	to	to	IN
cord-022353-q2k2krnm	422	18	levels	level	NNS
cord-022353-q2k2krnm	422	19	of	of	IN
cord-022353-q2k2krnm	422	20	HDL	hdl	NN
cord-022353-q2k2krnm	422	21	.	.	.
cord-022353-q2k2krnm	423	1	Thus	thus	RB
cord-022353-q2k2krnm	423	2	,	,	,
cord-022353-q2k2krnm	423	3	although	although	IN
cord-022353-q2k2krnm	423	4	LDL	LDL	NNP
cord-022353-q2k2krnm	423	5	promotes	promote	VBZ
cord-022353-q2k2krnm	423	6	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	423	7	,	,	,
cord-022353-q2k2krnm	423	8	HDL	HDL	NNP
cord-022353-q2k2krnm	423	9	protects	protect	VBZ
cord-022353-q2k2krnm	423	10	against	against	IN
cord-022353-q2k2krnm	423	11	it	-PRON-	PRP
cord-022353-q2k2krnm	423	12	(	(	-LRB-
cord-022353-q2k2krnm	423	13	National	National	NNP
cord-022353-q2k2krnm	423	14	Cholesterol	Cholesterol	NNP
cord-022353-q2k2krnm	423	15	Education	Education	NNP
cord-022353-q2k2krnm	423	16	Program	Program	NNP
cord-022353-q2k2krnm	423	17	1993	1993	CD
cord-022353-q2k2krnm	423	18	)	)	-RRB-
cord-022353-q2k2krnm	423	19	.	.	.
cord-022353-q2k2krnm	424	1	The	the	DT
cord-022353-q2k2krnm	424	2	combination	combination	NN
cord-022353-q2k2krnm	424	3	of	of	IN
cord-022353-q2k2krnm	424	4	high	high	JJ
cord-022353-q2k2krnm	424	5	LDL	ldl	NN
cord-022353-q2k2krnm	424	6	and	and	CC
cord-022353-q2k2krnm	424	7	low	low	JJ
cord-022353-q2k2krnm	424	8	HDL	HDL	NNP
cord-022353-q2k2krnm	424	9	is	be	VBZ
cord-022353-q2k2krnm	424	10	termed	term	VBN
cord-022353-q2k2krnm	424	11	dyslipidemia	dyslipidemia	NN
cord-022353-q2k2krnm	424	12	and	and	CC
cord-022353-q2k2krnm	424	13	is	be	VBZ
cord-022353-q2k2krnm	424	14	found	find	VBN
cord-022353-q2k2krnm	424	15	in	in	IN
cord-022353-q2k2krnm	424	16	human	human	JJ
cord-022353-q2k2krnm	424	17	patients	patient	NNS
cord-022353-q2k2krnm	424	18	with	with	IN
cord-022353-q2k2krnm	424	19	insulin	insulin	NN
cord-022353-q2k2krnm	424	20	resistance	resistance	NN
cord-022353-q2k2krnm	424	21	syndrome	syndrome	NN
cord-022353-q2k2krnm	424	22	.	.	.
cord-022353-q2k2krnm	425	1	Mice	mouse	NNS
cord-022353-q2k2krnm	425	2	do	do	VBP
cord-022353-q2k2krnm	425	3	not	not	RB
cord-022353-q2k2krnm	425	4	develop	develop	VB
cord-022353-q2k2krnm	425	5	spontaneous	spontaneous	JJ
cord-022353-q2k2krnm	425	6	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	425	7	,	,	,
cord-022353-q2k2krnm	425	8	because	because	IN
cord-022353-q2k2krnm	425	9	they	-PRON-	PRP
cord-022353-q2k2krnm	425	10	have	have	VBP
cord-022353-q2k2krnm	425	11	low	low	JJ
cord-022353-q2k2krnm	425	12	circulating	circulate	VBG
cord-022353-q2k2krnm	425	13	levels	level	NNS
cord-022353-q2k2krnm	425	14	of	of	IN
cord-022353-q2k2krnm	425	15	LDL	ldl	NN
cord-022353-q2k2krnm	425	16	and	and	CC
cord-022353-q2k2krnm	425	17	lack	lack	NN
cord-022353-q2k2krnm	425	18	CETP	CETP	NNP
cord-022353-q2k2krnm	425	19	activity	activity	NN
cord-022353-q2k2krnm	425	20	.	.	.
cord-022353-q2k2krnm	426	1	However	however	RB
cord-022353-q2k2krnm	426	2	,	,	,
cord-022353-q2k2krnm	426	3	genetically	genetically	RB
cord-022353-q2k2krnm	426	4	engineered	engineer	VBN
cord-022353-q2k2krnm	426	5	mice	mouse	NNS
cord-022353-q2k2krnm	426	6	that	that	IN
cord-022353-q2k2krnm	426	7	over	over	IN
cord-022353-q2k2krnm	426	8	-	-	HYPH
cord-022353-q2k2krnm	426	9	or	or	CC
cord-022353-q2k2krnm	426	10	under	under	IN
cord-022353-q2k2krnm	426	11	-	-	HYPH
cord-022353-q2k2krnm	426	12	express	express	NN
cord-022353-q2k2krnm	426	13	genes	gene	NNS
cord-022353-q2k2krnm	426	14	involved	involve	VBN
cord-022353-q2k2krnm	426	15	in	in	IN
cord-022353-q2k2krnm	426	16	lipid	lipid	NN
cord-022353-q2k2krnm	426	17	metabolism	metabolism	NN
cord-022353-q2k2krnm	426	18	have	have	VBP
cord-022353-q2k2krnm	426	19	contributed	contribute	VBN
cord-022353-q2k2krnm	426	20	greatly	greatly	RB
cord-022353-q2k2krnm	426	21	to	to	IN
cord-022353-q2k2krnm	426	22	our	-PRON-	PRP$
cord-022353-q2k2krnm	426	23	understanding	understanding	NN
cord-022353-q2k2krnm	426	24	of	of	IN
cord-022353-q2k2krnm	426	25	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	426	26	metabolism	metabolism	NN
cord-022353-q2k2krnm	426	27	(	(	-LRB-
cord-022353-q2k2krnm	426	28	Marschang	Marschang	NNP
cord-022353-q2k2krnm	426	29	and	and	CC
cord-022353-q2k2krnm	426	30	Herz	Herz	NNP
cord-022353-q2k2krnm	426	31	2003	2003	CD
cord-022353-q2k2krnm	426	32	)	)	-RRB-
cord-022353-q2k2krnm	426	33	.	.	.
cord-022353-q2k2krnm	427	1	In	in	IN
cord-022353-q2k2krnm	427	2	particular	particular	JJ
cord-022353-q2k2krnm	427	3	,	,	,
cord-022353-q2k2krnm	427	4	transgenic	transgenic	JJ
cord-022353-q2k2krnm	427	5	mice	mouse	NNS
cord-022353-q2k2krnm	427	6	have	have	VBP
cord-022353-q2k2krnm	427	7	been	be	VBN
cord-022353-q2k2krnm	427	8	developed	develop	VBN
cord-022353-q2k2krnm	427	9	with	with	IN
cord-022353-q2k2krnm	427	10	plasma	plasma	NN
cord-022353-q2k2krnm	427	11	lipid	lipid	NN
cord-022353-q2k2krnm	427	12	profiles	profile	NNS
cord-022353-q2k2krnm	427	13	that	that	WDT
cord-022353-q2k2krnm	427	14	are	be	VBP
cord-022353-q2k2krnm	427	15	similar	similar	JJ
cord-022353-q2k2krnm	427	16	to	to	IN
cord-022353-q2k2krnm	427	17	those	those	DT
cord-022353-q2k2krnm	427	18	of	of	IN
cord-022353-q2k2krnm	427	19	humans	human	NNS
cord-022353-q2k2krnm	427	20	with	with	IN
cord-022353-q2k2krnm	427	21	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	428	1	(	(	-LRB-
cord-022353-q2k2krnm	428	2	Breslow	Breslow	NNP
cord-022353-q2k2krnm	428	3	1994	1994	CD
cord-022353-q2k2krnm	428	4	(	(	-LRB-
cord-022353-q2k2krnm	428	5	Breslow	Breslow	NNP
cord-022353-q2k2krnm	428	6	,	,	,
cord-022353-q2k2krnm	428	7	1996	1996	CD
cord-022353-q2k2krnm	428	8	.	.	.
cord-022353-q2k2krnm	429	1	In	in	IN
cord-022353-q2k2krnm	429	2	humans	human	NNS
cord-022353-q2k2krnm	429	3	and	and	CC
cord-022353-q2k2krnm	429	4	transgenic	transgenic	JJ
cord-022353-q2k2krnm	429	5	mice	mouse	NNS
cord-022353-q2k2krnm	429	6	with	with	IN
cord-022353-q2k2krnm	429	7	elevated	elevated	JJ
cord-022353-q2k2krnm	429	8	LDL	ldl	NN
cord-022353-q2k2krnm	429	9	(	(	-LRB-
cord-022353-q2k2krnm	429	10	or	or	CC
cord-022353-q2k2krnm	429	11	low	low	JJ
cord-022353-q2k2krnm	429	12	HDL	HDL	NNP
cord-022353-q2k2krnm	429	13	)	)	-RRB-
cord-022353-q2k2krnm	429	14	,	,	,
cord-022353-q2k2krnm	429	15	LDL	LDL	NNP
cord-022353-q2k2krnm	429	16	passively	passively	RB
cord-022353-q2k2krnm	429	17	diffuses	diffuse	VBZ
cord-022353-q2k2krnm	429	18	across	across	IN
cord-022353-q2k2krnm	429	19	the	the	DT
cord-022353-q2k2krnm	429	20	endothelium	endothelium	NN
cord-022353-q2k2krnm	429	21	,	,	,
cord-022353-q2k2krnm	429	22	especially	especially	RB
cord-022353-q2k2krnm	429	23	in	in	IN
cord-022353-q2k2krnm	429	24	areas	area	NNS
cord-022353-q2k2krnm	429	25	where	where	WRB
cord-022353-q2k2krnm	429	26	endothelial	endothelial	JJ
cord-022353-q2k2krnm	429	27	cell	cell	NN
cord-022353-q2k2krnm	429	28	morphology	morphology	NN
cord-022353-q2k2krnm	429	29	has	have	VBZ
cord-022353-q2k2krnm	429	30	been	be	VBN
cord-022353-q2k2krnm	429	31	altered	alter	VBN
cord-022353-q2k2krnm	429	32	by	by	IN
cord-022353-q2k2krnm	429	33	the	the	DT
cord-022353-q2k2krnm	429	34	sheer	sheer	JJ
cord-022353-q2k2krnm	429	35	forces	force	NNS
cord-022353-q2k2krnm	429	36	generated	generate	VBN
cord-022353-q2k2krnm	429	37	by	by	IN
cord-022353-q2k2krnm	429	38	blood	blood	NN
cord-022353-q2k2krnm	429	39	turbulence	turbulence	NN
cord-022353-q2k2krnm	429	40	.	.	.
cord-022353-q2k2krnm	430	1	Once	once	IN
cord-022353-q2k2krnm	430	2	LDL	LDL	NNP
cord-022353-q2k2krnm	430	3	is	be	VBZ
cord-022353-q2k2krnm	430	4	within	within	IN
cord-022353-q2k2krnm	430	5	the	the	DT
cord-022353-q2k2krnm	430	6	intima	intima	NN
cord-022353-q2k2krnm	430	7	there	there	EX
cord-022353-q2k2krnm	430	8	is	be	VBZ
cord-022353-q2k2krnm	430	9	an	an	DT
cord-022353-q2k2krnm	430	10	interaction	interaction	NN
cord-022353-q2k2krnm	430	11	between	between	IN
cord-022353-q2k2krnm	430	12	LDLapoprotein	LDLapoprotein	NNP
cord-022353-q2k2krnm	430	13	B	b	NN
cord-022353-q2k2krnm	430	14	and	and	CC
cord-022353-q2k2krnm	430	15	matrix	matrix	NN
cord-022353-q2k2krnm	430	16	proteoglycans	proteoglycan	NNS
cord-022353-q2k2krnm	430	17	resulting	result	VBG
cord-022353-q2k2krnm	430	18	in	in	IN
cord-022353-q2k2krnm	430	19	LDL	ldl	NN
cord-022353-q2k2krnm	430	20	trapping	trapping	NN
cord-022353-q2k2krnm	430	21	.	.	.
cord-022353-q2k2krnm	431	1	LDL	ldl	NN
cord-022353-q2k2krnm	431	2	undergoes	undergo	VBZ
cord-022353-q2k2krnm	431	3	modifications	modification	NNS
cord-022353-q2k2krnm	431	4	associated	associate	VBN
cord-022353-q2k2krnm	431	5	with	with	IN
cord-022353-q2k2krnm	431	6	oxidation	oxidation	NN
cord-022353-q2k2krnm	431	7	,	,	,
cord-022353-q2k2krnm	431	8	lipolysis	lipolysis	NN
cord-022353-q2k2krnm	431	9	,	,	,
cord-022353-q2k2krnm	431	10	proteolysis	proteolysis	NN
cord-022353-q2k2krnm	431	11	,	,	,
cord-022353-q2k2krnm	431	12	and	and	CC
cord-022353-q2k2krnm	431	13	aggregation	aggregation	NN
cord-022353-q2k2krnm	431	14	that	that	WDT
cord-022353-q2k2krnm	431	15	contribute	contribute	VBP
cord-022353-q2k2krnm	431	16	to	to	IN
cord-022353-q2k2krnm	431	17	inflammation	inflammation	NN
cord-022353-q2k2krnm	431	18	and	and	CC
cord-022353-q2k2krnm	431	19	uptake	uptake	NN
cord-022353-q2k2krnm	431	20	of	of	IN
cord-022353-q2k2krnm	431	21	LDL	ldl	NN
cord-022353-q2k2krnm	431	22	by	by	IN
cord-022353-q2k2krnm	431	23	tissue	tissue	NN
cord-022353-q2k2krnm	431	24	macrophages	macrophage	NNS
cord-022353-q2k2krnm	431	25	.	.	.
cord-022353-q2k2krnm	432	1	Lipoxygenases	Lipoxygenases	NNP
cord-022353-q2k2krnm	432	2	(	(	-LRB-
cord-022353-q2k2krnm	432	3	LOs	LOs	NNP
cord-022353-q2k2krnm	432	4	)	)	-RRB-
cord-022353-q2k2krnm	432	5	insert	insert	VB
cord-022353-q2k2krnm	432	6	molecular	molecular	JJ
cord-022353-q2k2krnm	432	7	oxygen	oxygen	NN
cord-022353-q2k2krnm	432	8	into	into	IN
cord-022353-q2k2krnm	432	9	polyenoic	polyenoic	NNP
cord-022353-q2k2krnm	432	10	fatty	fatty	JJ
cord-022353-q2k2krnm	432	11	acids	acid	NNS
cord-022353-q2k2krnm	432	12	producing	produce	VBG
cord-022353-q2k2krnm	432	13	hydroperoxyeicosatetraenoic	hydroperoxyeicosatetraenoic	NNP
cord-022353-q2k2krnm	432	14	acid	acid	NNP
cord-022353-q2k2krnm	432	15	(	(	-LRB-
cord-022353-q2k2krnm	432	16	HETE	HETE	NNP
cord-022353-q2k2krnm	432	17	)	)	-RRB-
cord-022353-q2k2krnm	432	18	.	.	.
cord-022353-q2k2krnm	433	1	Endothelial	endothelial	NN
cord-022353-q2k2krnm	433	2	cells	cell	NNS
cord-022353-q2k2krnm	433	3	release	release	VBP
cord-022353-q2k2krnm	433	4	HETE	HETE	NNP
cord-022353-q2k2krnm	433	5	into	into	IN
cord-022353-q2k2krnm	433	6	the	the	DT
cord-022353-q2k2krnm	433	7	vessel	vessel	NN
cord-022353-q2k2krnm	433	8	wall	wall	NN
cord-022353-q2k2krnm	433	9	,	,	,
cord-022353-q2k2krnm	433	10	where	where	WRB
cord-022353-q2k2krnm	433	11	it	-PRON-	PRP
cord-022353-q2k2krnm	433	12	initiates	initiate	VBZ
cord-022353-q2k2krnm	433	13	oxidation	oxidation	NN
cord-022353-q2k2krnm	433	14	of	of	IN
cord-022353-q2k2krnm	433	15	LDL	ldl	NN
cord-022353-q2k2krnm	433	16	.	.	.
cord-022353-q2k2krnm	434	1	Further	further	JJ
cord-022353-q2k2krnm	434	2	oxidation	oxidation	NN
cord-022353-q2k2krnm	434	3	of	of	IN
cord-022353-q2k2krnm	434	4	LDL	ldl	NN
cord-022353-q2k2krnm	434	5	is	be	VBZ
cord-022353-q2k2krnm	434	6	aided	aid	VBN
cord-022353-q2k2krnm	434	7	by	by	IN
cord-022353-q2k2krnm	434	8	myeloperoxidase	myeloperoxidase	NNP
cord-022353-q2k2krnm	434	9	and	and	CC
cord-022353-q2k2krnm	434	10	sphingomyelinase	sphingomyelinase	NNP
cord-022353-q2k2krnm	434	11	.	.	.
cord-022353-q2k2krnm	435	1	Mice	mouse	NNS
cord-022353-q2k2krnm	435	2	lacking	lack	VBG
cord-022353-q2k2krnm	435	3	LOs	LOs	NNP
cord-022353-q2k2krnm	435	4	have	have	VBP
cord-022353-q2k2krnm	435	5	diminished	diminish	VBN
cord-022353-q2k2krnm	435	6	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	435	7	.	.	.
cord-022353-q2k2krnm	436	1	Macrophages	macrophage	NNS
cord-022353-q2k2krnm	436	2	and	and	CC
cord-022353-q2k2krnm	436	3	monocytes	monocyte	NNS
cord-022353-q2k2krnm	436	4	recognize	recognize	VBP
cord-022353-q2k2krnm	436	5	oxidized	oxidize	VBN
cord-022353-q2k2krnm	436	6	LDL	ldl	NN
cord-022353-q2k2krnm	436	7	via	via	IN
cord-022353-q2k2krnm	436	8	their	-PRON-	PRP$
cord-022353-q2k2krnm	436	9	surface	surface	NN
cord-022353-q2k2krnm	436	10	scavenger	scavenger	NN
cord-022353-q2k2krnm	436	11	receptors	receptor	NNS
cord-022353-q2k2krnm	436	12	and	and	CC
cord-022353-q2k2krnm	436	13	become	become	VBP
cord-022353-q2k2krnm	436	14	loaded	load	VBN
cord-022353-q2k2krnm	436	15	with	with	IN
cord-022353-q2k2krnm	436	16	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	436	17	ester	ester	NN
cord-022353-q2k2krnm	436	18	,	,	,
cord-022353-q2k2krnm	436	19	forming	form	VBG
cord-022353-q2k2krnm	436	20	a	a	DT
cord-022353-q2k2krnm	436	21	fatty	fatty	JJ
cord-022353-q2k2krnm	436	22	streak	streak	NN
cord-022353-q2k2krnm	436	23	appearing	appear	VBG
cord-022353-q2k2krnm	436	24	along	along	IN
cord-022353-q2k2krnm	436	25	the	the	DT
cord-022353-q2k2krnm	436	26	vessel	vessel	NN
cord-022353-q2k2krnm	436	27	wall	wall	NN
cord-022353-q2k2krnm	436	28	.	.	.
cord-022353-q2k2krnm	437	1	HDL	HDL	NNP
cord-022353-q2k2krnm	437	2	,	,	,
cord-022353-q2k2krnm	437	3	on	on	IN
cord-022353-q2k2krnm	437	4	the	the	DT
cord-022353-q2k2krnm	437	5	other	other	JJ
cord-022353-q2k2krnm	437	6	hand	hand	NN
cord-022353-q2k2krnm	437	7	,	,	,
cord-022353-q2k2krnm	437	8	removes	remove	VBZ
cord-022353-q2k2krnm	437	9	excess	excess	JJ
cord-022353-q2k2krnm	437	10	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	437	11	from	from	IN
cord-022353-q2k2krnm	437	12	peripheral	peripheral	JJ
cord-022353-q2k2krnm	437	13	tissue	tissue	NN
cord-022353-q2k2krnm	437	14	and	and	CC
cord-022353-q2k2krnm	437	15	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	437	16	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	437	17	oxidation	oxidation	NN
cord-022353-q2k2krnm	437	18	.	.	.
cord-022353-q2k2krnm	438	1	HDL	HDL	NNP
cord-022353-q2k2krnm	438	2	carries	carry	VBZ
cord-022353-q2k2krnm	438	3	paraoxonase	paraoxonase	NN
cord-022353-q2k2krnm	438	4	,	,	,
cord-022353-q2k2krnm	438	5	which	which	WDT
cord-022353-q2k2krnm	438	6	degrades	degrade	VBZ
cord-022353-q2k2krnm	438	7	oxidized	oxidize	VBN
cord-022353-q2k2krnm	438	8	phospholipids	phospholipid	NNS
cord-022353-q2k2krnm	438	9	(	(	-LRB-
cord-022353-q2k2krnm	438	10	Lusis	Lusis	NNP
cord-022353-q2k2krnm	438	11	2000	2000	CD
cord-022353-q2k2krnm	438	12	)	)	-RRB-
cord-022353-q2k2krnm	438	13	and	and	CC
cord-022353-q2k2krnm	438	14	protects	protect	VBZ
cord-022353-q2k2krnm	438	15	against	against	IN
cord-022353-q2k2krnm	438	16	subsequent	subsequent	JJ
cord-022353-q2k2krnm	438	17	oxidative	oxidative	JJ
cord-022353-q2k2krnm	438	18	damage	damage	NN
cord-022353-q2k2krnm	438	19	.	.	.
cord-022353-q2k2krnm	439	1	Oxidized	oxidize	VBN
cord-022353-q2k2krnm	439	2	LDL	ldl	NN
cord-022353-q2k2krnm	439	3	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	439	4	endothelial	endothelial	JJ
cord-022353-q2k2krnm	439	5	cells	cell	NNS
cord-022353-q2k2krnm	439	6	to	to	TO
cord-022353-q2k2krnm	439	7	express	express	VB
cord-022353-q2k2krnm	439	8	adhesion	adhesion	NN
cord-022353-q2k2krnm	439	9	molecules	molecule	NNS
cord-022353-q2k2krnm	439	10	(	(	-LRB-
cord-022353-q2k2krnm	439	11	such	such	JJ
cord-022353-q2k2krnm	439	12	as	as	IN
cord-022353-q2k2krnm	439	13	ICAM	ICAM	NNP
cord-022353-q2k2krnm	439	14	,	,	,
cord-022353-q2k2krnm	439	15	VLA-4	VLA-4	NNP
cord-022353-q2k2krnm	439	16	,	,	,
cord-022353-q2k2krnm	439	17	and	and	CC
cord-022353-q2k2krnm	439	18	VCAM	VCAM	NNP
cord-022353-q2k2krnm	439	19	)	)	-RRB-
cord-022353-q2k2krnm	439	20	and	and	CC
cord-022353-q2k2krnm	439	21	monocyte	monocyte	NNP
cord-022353-q2k2krnm	439	22	colony	colony	NN
cord-022353-q2k2krnm	439	23	-	-	HYPH
cord-022353-q2k2krnm	439	24	stimulating	stimulate	VBG
cord-022353-q2k2krnm	439	25	factor	factor	NN
cord-022353-q2k2krnm	439	26	(	(	-LRB-
cord-022353-q2k2krnm	439	27	M	M	NNP
cord-022353-q2k2krnm	439	28	-	-	HYPH
cord-022353-q2k2krnm	439	29	CSF	CSF	NNP
cord-022353-q2k2krnm	439	30	)	)	-RRB-
cord-022353-q2k2krnm	439	31	on	on	IN
cord-022353-q2k2krnm	439	32	their	-PRON-	PRP$
cord-022353-q2k2krnm	439	33	luminal	luminal	JJ
cord-022353-q2k2krnm	439	34	surface	surface	NN
cord-022353-q2k2krnm	439	35	,	,	,
cord-022353-q2k2krnm	439	36	which	which	WDT
cord-022353-q2k2krnm	439	37	attracts	attract	VBZ
cord-022353-q2k2krnm	439	38	additional	additional	JJ
cord-022353-q2k2krnm	439	39	monocytes	monocyte	NNS
cord-022353-q2k2krnm	439	40	and	and	CC
cord-022353-q2k2krnm	439	41	lymphocytes	lymphocyte	NNS
cord-022353-q2k2krnm	439	42	.	.	.
cord-022353-q2k2krnm	440	1	Oxidized	oxidize	VBN
cord-022353-q2k2krnm	440	2	LDL	LDL	NNP
cord-022353-q2k2krnm	440	3	also	also	RB
cord-022353-q2k2krnm	440	4	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	440	5	nitric	nitric	NN
cord-022353-q2k2krnm	440	6	oxide	oxide	NN
cord-022353-q2k2krnm	440	7	production	production	NN
cord-022353-q2k2krnm	440	8	.	.	.
cord-022353-q2k2krnm	441	1	Infiltrating	infiltrate	VBG
cord-022353-q2k2krnm	441	2	thymic	thymic	JJ
cord-022353-q2k2krnm	441	3	-	-	HYPH
cord-022353-q2k2krnm	441	4	derived	derive	VBN
cord-022353-q2k2krnm	441	5	lymphocytes	lymphocyte	NNS
cord-022353-q2k2krnm	441	6	(	(	-LRB-
cord-022353-q2k2krnm	441	7	T	t	NN
cord-022353-q2k2krnm	441	8	cells	cell	NNS
cord-022353-q2k2krnm	441	9	)	)	-RRB-
cord-022353-q2k2krnm	441	10	and	and	CC
cord-022353-q2k2krnm	441	11	macrophages	macrophage	NNS
cord-022353-q2k2krnm	441	12	initiate	initiate	VBP
cord-022353-q2k2krnm	441	13	migration	migration	NN
cord-022353-q2k2krnm	441	14	of	of	IN
cord-022353-q2k2krnm	441	15	smooth	smooth	JJ
cord-022353-q2k2krnm	441	16	muscle	muscle	NN
cord-022353-q2k2krnm	441	17	cells	cell	NNS
cord-022353-q2k2krnm	441	18	from	from	IN
cord-022353-q2k2krnm	441	19	the	the	DT
cord-022353-q2k2krnm	441	20	media	medium	NNS
cord-022353-q2k2krnm	441	21	to	to	IN
cord-022353-q2k2krnm	441	22	the	the	DT
cord-022353-q2k2krnm	441	23	intima	intima	NN
cord-022353-q2k2krnm	441	24	,	,	,
cord-022353-q2k2krnm	441	25	where	where	WRB
cord-022353-q2k2krnm	441	26	they	-PRON-	PRP
cord-022353-q2k2krnm	441	27	synthesize	synthesize	VBP
cord-022353-q2k2krnm	441	28	matrix	matrix	NN
cord-022353-q2k2krnm	441	29	components	component	NNS
cord-022353-q2k2krnm	441	30	.	.	.
cord-022353-q2k2krnm	442	1	MCP-1	MCP-1	NNP
cord-022353-q2k2krnm	442	2	is	be	VBZ
cord-022353-q2k2krnm	442	3	also	also	RB
cord-022353-q2k2krnm	442	4	released	release	VBN
cord-022353-q2k2krnm	442	5	by	by	IN
cord-022353-q2k2krnm	442	6	macrophages	macrophage	NNS
cord-022353-q2k2krnm	442	7	,	,	,
cord-022353-q2k2krnm	442	8	inducing	induce	VBG
cord-022353-q2k2krnm	442	9	monocyte	monocyte	JJ
cord-022353-q2k2krnm	442	10	differentiation	differentiation	NN
cord-022353-q2k2krnm	442	11	,	,	,
cord-022353-q2k2krnm	442	12	migration	migration	NN
cord-022353-q2k2krnm	442	13	,	,	,
cord-022353-q2k2krnm	442	14	and	and	CC
cord-022353-q2k2krnm	442	15	scavenger	scavenger	NN
cord-022353-q2k2krnm	442	16	receptor	receptor	NN
cord-022353-q2k2krnm	442	17	expression	expression	NN
cord-022353-q2k2krnm	442	18	.	.	.
cord-022353-q2k2krnm	443	1	The	the	DT
cord-022353-q2k2krnm	443	2	accumulation	accumulation	NN
cord-022353-q2k2krnm	443	3	of	of	IN
cord-022353-q2k2krnm	443	4	excess	excess	JJ
cord-022353-q2k2krnm	443	5	free	free	JJ
cord-022353-q2k2krnm	443	6	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	443	7	can	can	MD
cord-022353-q2k2krnm	443	8	be	be	VB
cord-022353-q2k2krnm	443	9	inhibited	inhibit	VBN
cord-022353-q2k2krnm	443	10	by	by	IN
cord-022353-q2k2krnm	443	11	activation	activation	NN
cord-022353-q2k2krnm	443	12	of	of	IN
cord-022353-q2k2krnm	443	13	acyl	acyl	NNP
cord-022353-q2k2krnm	443	14	CoA	CoA	NNP
cord-022353-q2k2krnm	443	15	:	:	:
cord-022353-q2k2krnm	443	16	cholesterol	cholesterol	NNP
cord-022353-q2k2krnm	443	17	acyltransferase	acyltransferase	NNP
cord-022353-q2k2krnm	443	18	(	(	-LRB-
cord-022353-q2k2krnm	443	19	ACAT)mediated	acat)mediated	JJ
cord-022353-q2k2krnm	443	20	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	443	21	esterification	esterification	NN
cord-022353-q2k2krnm	443	22	and	and	CC
cord-022353-q2k2krnm	443	23	cellular	cellular	JJ
cord-022353-q2k2krnm	443	24	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	443	25	effiux	effiux	NN
cord-022353-q2k2krnm	443	26	.	.	.
cord-022353-q2k2krnm	444	1	One	one	CD
cord-022353-q2k2krnm	444	2	mechanism	mechanism	NN
cord-022353-q2k2krnm	444	3	responsible	responsible	JJ
cord-022353-q2k2krnm	444	4	for	for	IN
cord-022353-q2k2krnm	444	5	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	444	6	effiux	effiux	NN
cord-022353-q2k2krnm	444	7	is	be	VBZ
cord-022353-q2k2krnm	444	8	secretion	secretion	NN
cord-022353-q2k2krnm	444	9	of	of	IN
cord-022353-q2k2krnm	444	10	apoprotein	apoprotein	NN
cord-022353-q2k2krnm	444	11	E	E	NNP
cord-022353-q2k2krnm	444	12	by	by	IN
cord-022353-q2k2krnm	444	13	macrophages	macrophage	NNS
cord-022353-q2k2krnm	444	14	that	that	WDT
cord-022353-q2k2krnm	444	15	promotes	promote	VBZ
cord-022353-q2k2krnm	444	16	effiux	effiux	NN
cord-022353-q2k2krnm	444	17	via	via	IN
cord-022353-q2k2krnm	444	18	HDL	HDL	NNP
cord-022353-q2k2krnm	444	19	.	.	.
cord-022353-q2k2krnm	445	1	If	if	IN
cord-022353-q2k2krnm	445	2	this	this	DT
cord-022353-q2k2krnm	445	3	fails	fail	VBZ
cord-022353-q2k2krnm	445	4	,	,	,
cord-022353-q2k2krnm	445	5	as	as	IN
cord-022353-q2k2krnm	445	6	in	in	IN
cord-022353-q2k2krnm	445	7	the	the	DT
cord-022353-q2k2krnm	445	8	case	case	NN
cord-022353-q2k2krnm	445	9	of	of	IN
cord-022353-q2k2krnm	445	10	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	445	11	-	-	HYPH
cord-022353-q2k2krnm	445	12	laden	laden	JJ
cord-022353-q2k2krnm	445	13	macrophages	macrophage	NNS
cord-022353-q2k2krnm	445	14	in	in	IN
cord-022353-q2k2krnm	445	15	plaques	plaque	NNS
cord-022353-q2k2krnm	445	16	,	,	,
cord-022353-q2k2krnm	445	17	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	445	18	of	of	IN
cord-022353-q2k2krnm	445	19	the	the	DT
cord-022353-q2k2krnm	445	20	macrophages	macrophage	NNS
cord-022353-q2k2krnm	445	21	ensues	ensue	VBZ
cord-022353-q2k2krnm	445	22	.	.	.
cord-022353-q2k2krnm	446	1	Loading	load	VBG
cord-022353-q2k2krnm	446	2	of	of	IN
cord-022353-q2k2krnm	446	3	the	the	DT
cord-022353-q2k2krnm	446	4	endoplasmic	endoplasmic	NN
cord-022353-q2k2krnm	446	5	reticulum	reticulum	NN
cord-022353-q2k2krnm	446	6	with	with	IN
cord-022353-q2k2krnm	446	7	free	free	JJ
cord-022353-q2k2krnm	446	8	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	446	9	activates	activate	VBZ
cord-022353-q2k2krnm	446	10	ER	ER	NNP
cord-022353-q2k2krnm	446	11	resident	resident	NN
cord-022353-q2k2krnm	446	12	protein	protein	NN
cord-022353-q2k2krnm	446	13	kinase	kinase	NN
cord-022353-q2k2krnm	446	14	and	and	CC
cord-022353-q2k2krnm	446	15	the	the	DT
cord-022353-q2k2krnm	446	16	unfolded	unfold	VBN
cord-022353-q2k2krnm	446	17	protein	protein	NN
cord-022353-q2k2krnm	446	18	response	response	NN
cord-022353-q2k2krnm	446	19	(	(	-LRB-
cord-022353-q2k2krnm	446	20	UPR	UPR	NNP
cord-022353-q2k2krnm	446	21	)	)	-RRB-
cord-022353-q2k2krnm	446	22	that	that	WDT
cord-022353-q2k2krnm	446	23	initiates	initiate	VBZ
cord-022353-q2k2krnm	446	24	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	446	25	through	through	IN
cord-022353-q2k2krnm	446	26	activation	activation	NN
cord-022353-q2k2krnm	446	27	of	of	IN
cord-022353-q2k2krnm	447	1	caspase-12	caspase-12	NFP
cord-022353-q2k2krnm	447	2	(	(	-LRB-
cord-022353-q2k2krnm	447	3	Feng	Feng	NNP
cord-022353-q2k2krnm	447	4	et	et	FW
cord-022353-q2k2krnm	447	5	al	al	NNP
cord-022353-q2k2krnm	447	6	.	.	NNP
cord-022353-q2k2krnm	447	7	2003a	2003a	CD
cord-022353-q2k2krnm	447	8	)	)	-RRB-
cord-022353-q2k2krnm	447	9	.	.	.
cord-022353-q2k2krnm	448	1	As	as	IN
cord-022353-q2k2krnm	448	2	macrophages	macrophage	NNS
cord-022353-q2k2krnm	448	3	undergo	undergo	VBP
cord-022353-q2k2krnm	448	4	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	448	5	they	-PRON-	PRP
cord-022353-q2k2krnm	448	6	create	create	VBP
cord-022353-q2k2krnm	448	7	a	a	DT
cord-022353-q2k2krnm	448	8	necrotic	necrotic	JJ
cord-022353-q2k2krnm	448	9	core	core	NN
cord-022353-q2k2krnm	448	10	in	in	IN
cord-022353-q2k2krnm	448	11	the	the	DT
cord-022353-q2k2krnm	448	12	plaque	plaque	NN
cord-022353-q2k2krnm	448	13	,	,	,
cord-022353-q2k2krnm	448	14	promoting	promote	VBG
cord-022353-q2k2krnm	448	15	extracellular	extracellular	JJ
cord-022353-q2k2krnm	448	16	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	448	17	cleft	cleft	NN
cord-022353-q2k2krnm	448	18	formation	formation	NN
cord-022353-q2k2krnm	448	19	.	.	.
cord-022353-q2k2krnm	449	1	Smooth	smooth	JJ
cord-022353-q2k2krnm	449	2	muscle	muscle	NN
cord-022353-q2k2krnm	449	3	cells	cell	NNS
cord-022353-q2k2krnm	449	4	create	create	VBP
cord-022353-q2k2krnm	449	5	a	a	DT
cord-022353-q2k2krnm	449	6	fibrous	fibrous	JJ
cord-022353-q2k2krnm	449	7	cap	cap	NN
cord-022353-q2k2krnm	449	8	over	over	IN
cord-022353-q2k2krnm	449	9	the	the	DT
cord-022353-q2k2krnm	449	10	plaque	plaque	NN
cord-022353-q2k2krnm	449	11	near	near	IN
cord-022353-q2k2krnm	449	12	the	the	DT
cord-022353-q2k2krnm	449	13	luminal	luminal	JJ
cord-022353-q2k2krnm	449	14	surface	surface	NN
cord-022353-q2k2krnm	449	15	.	.	.
cord-022353-q2k2krnm	450	1	The	the	DT
cord-022353-q2k2krnm	450	2	lesion	lesion	NN
cord-022353-q2k2krnm	450	3	advances	advance	VBZ
cord-022353-q2k2krnm	450	4	as	as	IN
cord-022353-q2k2krnm	450	5	T	T	NNP
cord-022353-q2k2krnm	450	6	cells	cell	NNS
cord-022353-q2k2krnm	450	7	,	,	,
cord-022353-q2k2krnm	450	8	activated	activate	VBN
cord-022353-q2k2krnm	450	9	by	by	IN
cord-022353-q2k2krnm	450	10	CD40-CD40L	cd40-cd40l	NN
cord-022353-q2k2krnm	450	11	ligation	ligation	NN
cord-022353-q2k2krnm	450	12	,	,	,
cord-022353-q2k2krnm	450	13	release	release	NN
cord-022353-q2k2krnm	450	14	cytokines	cytokine	NNS
cord-022353-q2k2krnm	450	15	such	such	JJ
cord-022353-q2k2krnm	450	16	as	as	IN
cord-022353-q2k2krnm	450	17	interferon-3	interferon-3	NNP
cord-022353-q2k2krnm	450	18	,	,	,
cord-022353-q2k2krnm	450	19	(	(	-LRB-
cord-022353-q2k2krnm	450	20	IFN	IFN	NNP
cord-022353-q2k2krnm	450	21	-	-	HYPH
cord-022353-q2k2krnm	450	22	y	y	NNP
cord-022353-q2k2krnm	450	23	)	)	-RRB-
cord-022353-q2k2krnm	450	24	and	and	CC
cord-022353-q2k2krnm	450	25	TNF	TNF	NNP
cord-022353-q2k2krnm	450	26	-	-	HYPH
cord-022353-q2k2krnm	450	27	ct	ct	NNP
cord-022353-q2k2krnm	450	28	.	.	.
cord-022353-q2k2krnm	451	1	These	these	DT
cord-022353-q2k2krnm	451	2	substances	substance	NNS
cord-022353-q2k2krnm	451	3	activate	activate	VBP
cord-022353-q2k2krnm	451	4	matrix	matrix	NN
cord-022353-q2k2krnm	451	5	degrading	degrade	VBG
cord-022353-q2k2krnm	451	6	proteases	protease	NNS
cord-022353-q2k2krnm	451	7	and	and	CC
cord-022353-q2k2krnm	451	8	adhesion	adhesion	NN
cord-022353-q2k2krnm	451	9	molecules	molecule	NNS
cord-022353-q2k2krnm	451	10	,	,	,
cord-022353-q2k2krnm	451	11	promoting	promote	VBG
cord-022353-q2k2krnm	451	12	additional	additional	JJ
cord-022353-q2k2krnm	451	13	inflammation	inflammation	NN
cord-022353-q2k2krnm	451	14	.	.	.
cord-022353-q2k2krnm	452	1	As	as	IN
cord-022353-q2k2krnm	452	2	the	the	DT
cord-022353-q2k2krnm	452	3	inflammation	inflammation	NN
cord-022353-q2k2krnm	452	4	progresses	progress	VBZ
cord-022353-q2k2krnm	452	5	the	the	DT
cord-022353-q2k2krnm	452	6	fibrous	fibrous	JJ
cord-022353-q2k2krnm	452	7	cap	cap	NN
cord-022353-q2k2krnm	452	8	becomes	become	VBZ
cord-022353-q2k2krnm	452	9	compromised	compromised	JJ
cord-022353-q2k2krnm	452	10	,	,	,
cord-022353-q2k2krnm	452	11	leading	lead	VBG
cord-022353-q2k2krnm	452	12	to	to	IN
cord-022353-q2k2krnm	452	13	physical	physical	JJ
cord-022353-q2k2krnm	452	14	rupture	rupture	NN
cord-022353-q2k2krnm	452	15	and	and	CC
cord-022353-q2k2krnm	452	16	the	the	DT
cord-022353-q2k2krnm	452	17	generation	generation	NN
cord-022353-q2k2krnm	452	18	of	of	IN
cord-022353-q2k2krnm	452	19	a	a	DT
cord-022353-q2k2krnm	452	20	thrombogenic	thrombogenic	JJ
cord-022353-q2k2krnm	452	21	surface	surface	NN
cord-022353-q2k2krnm	452	22	.	.	.
cord-022353-q2k2krnm	453	1	Oxidized	oxidize	VBN
cord-022353-q2k2krnm	453	2	LDL	ldl	NN
cord-022353-q2k2krnm	453	3	increases	increase	VBZ
cord-022353-q2k2krnm	453	4	the	the	DT
cord-022353-q2k2krnm	453	5	production	production	NN
cord-022353-q2k2krnm	453	6	of	of	IN
cord-022353-q2k2krnm	453	7	tissue	tissue	NN
cord-022353-q2k2krnm	453	8	factor	factor	NN
cord-022353-q2k2krnm	453	9	that	that	WDT
cord-022353-q2k2krnm	453	10	,	,	,
cord-022353-q2k2krnm	453	11	on	on	IN
cord-022353-q2k2krnm	453	12	the	the	DT
cord-022353-q2k2krnm	453	13	thrombogenic	thrombogenic	NNP
cord-022353-q2k2krnm	453	14	surface	surface	NN
cord-022353-q2k2krnm	453	15	,	,	,
cord-022353-q2k2krnm	453	16	initiates	initiate	VBZ
cord-022353-q2k2krnm	453	17	the	the	DT
cord-022353-q2k2krnm	453	18	coagulation	coagulation	NN
cord-022353-q2k2krnm	453	19	cascade	cascade	NN
cord-022353-q2k2krnm	453	20	and	and	CC
cord-022353-q2k2krnm	453	21	thrombus	thrombus	NN
cord-022353-q2k2krnm	453	22	formation	formation	NN
cord-022353-q2k2krnm	453	23	.	.	.
cord-022353-q2k2krnm	454	1	Each	each	DT
cord-022353-q2k2krnm	454	2	of	of	IN
cord-022353-q2k2krnm	454	3	these	these	DT
cord-022353-q2k2krnm	454	4	details	detail	NNS
cord-022353-q2k2krnm	454	5	have	have	VBP
cord-022353-q2k2krnm	454	6	been	be	VBN
cord-022353-q2k2krnm	454	7	elucidated	elucidate	VBN
cord-022353-q2k2krnm	454	8	using	use	VBG
cord-022353-q2k2krnm	454	9	genetically	genetically	RB
cord-022353-q2k2krnm	454	10	modified	modify	VBN
cord-022353-q2k2krnm	454	11	mice	mouse	NNS
cord-022353-q2k2krnm	454	12	(	(	-LRB-
cord-022353-q2k2krnm	454	13	Auerbach	Auerbach	NNP
cord-022353-q2k2krnm	454	14	et	et	NNP
cord-022353-q2k2krnm	454	15	al	al	NNP
cord-022353-q2k2krnm	454	16	.	.	NNP
cord-022353-q2k2krnm	454	17	1992	1992	CD
cord-022353-q2k2krnm	454	18	;	;	:
cord-022353-q2k2krnm	454	19	Choudhury	Choudhury	NNP
cord-022353-q2k2krnm	454	20	et	et	NNP
cord-022353-q2k2krnm	454	21	al	al	NNP
cord-022353-q2k2krnm	454	22	.	.	.
cord-022353-q2k2krnm	454	23	2004	2004	CD
cord-022353-q2k2krnm	454	24	;	;	:
cord-022353-q2k2krnm	454	25	Feng	Feng	NNP
cord-022353-q2k2krnm	454	26	et	et	FW
cord-022353-q2k2krnm	454	27	al	al	NNP
cord-022353-q2k2krnm	454	28	.	.	NNP
cord-022353-q2k2krnm	454	29	2003b	2003b	CD
cord-022353-q2k2krnm	454	30	;	;	:
cord-022353-q2k2krnm	455	1	Lusis	Lusis	NNP
cord-022353-q2k2krnm	455	2	2000	2000	CD
cord-022353-q2k2krnm	455	3	;	;	:
cord-022353-q2k2krnm	455	4	Reardon	Reardon	NNP
cord-022353-q2k2krnm	455	5	and	and	CC
cord-022353-q2k2krnm	455	6	Getz	Getz	NNP
cord-022353-q2k2krnm	455	7	2001	2001	CD
cord-022353-q2k2krnm	455	8	;	;	:
cord-022353-q2k2krnm	455	9	Tailleux	Tailleux	NNP
cord-022353-q2k2krnm	455	10	et	et	FW
cord-022353-q2k2krnm	455	11	al	al	NNP
cord-022353-q2k2krnm	455	12	.	.	.
cord-022353-q2k2krnm	456	1	2003	2003	CD
cord-022353-q2k2krnm	456	2	;	;	:
cord-022353-q2k2krnm	456	3	Trigatti	Trigatti	NNP
cord-022353-q2k2krnm	456	4	et	et	NNP
cord-022353-q2k2krnm	456	5	al	al	NNP
cord-022353-q2k2krnm	456	6	.	.	.
cord-022353-q2k2krnm	456	7	2004	2004	CD
cord-022353-q2k2krnm	456	8	)	)	-RRB-
cord-022353-q2k2krnm	456	9	.	.	.
cord-022353-q2k2krnm	457	1	For	for	IN
cord-022353-q2k2krnm	457	2	a	a	DT
cord-022353-q2k2krnm	457	3	further	further	JJ
cord-022353-q2k2krnm	457	4	discussion	discussion	NN
cord-022353-q2k2krnm	457	5	of	of	IN
cord-022353-q2k2krnm	457	6	these	these	DT
cord-022353-q2k2krnm	457	7	models	model	NNS
cord-022353-q2k2krnm	457	8	readers	reader	NNS
cord-022353-q2k2krnm	457	9	are	be	VBP
cord-022353-q2k2krnm	457	10	urged	urge	VBN
cord-022353-q2k2krnm	457	11	to	to	TO
cord-022353-q2k2krnm	457	12	read	read	VB
cord-022353-q2k2krnm	457	13	Chapter	chapter	NN
cord-022353-q2k2krnm	457	14	16	16	CD
cord-022353-q2k2krnm	457	15	in	in	IN
cord-022353-q2k2krnm	457	16	this	this	DT
cord-022353-q2k2krnm	457	17	book	book	NN
cord-022353-q2k2krnm	457	18	.	.	.
cord-022353-q2k2krnm	458	1	For	for	IN
cord-022353-q2k2krnm	458	2	measurements	measurement	NNS
cord-022353-q2k2krnm	458	3	of	of	IN
cord-022353-q2k2krnm	458	4	plasma	plasma	NN
cord-022353-q2k2krnm	458	5	lipids	lipid	NNS
cord-022353-q2k2krnm	458	6	,	,	,
cord-022353-q2k2krnm	458	7	serum	serum	NN
cord-022353-q2k2krnm	458	8	is	be	VBZ
cord-022353-q2k2krnm	458	9	the	the	DT
cord-022353-q2k2krnm	458	10	preferred	preferred	JJ
cord-022353-q2k2krnm	458	11	sample	sample	NN
cord-022353-q2k2krnm	458	12	.	.	.
cord-022353-q2k2krnm	459	1	Serum	serum	NN
cord-022353-q2k2krnm	459	2	can	can	MD
cord-022353-q2k2krnm	459	3	be	be	VB
cord-022353-q2k2krnm	459	4	stored	store	VBN
cord-022353-q2k2krnm	459	5	at	at	IN
cord-022353-q2k2krnm	459	6	4~	4~	CD
cord-022353-q2k2krnm	459	7	for	for	IN
cord-022353-q2k2krnm	459	8	5	5	CD
cord-022353-q2k2krnm	459	9	-	-	SYM
cord-022353-q2k2krnm	459	10	7	7	CD
cord-022353-q2k2krnm	459	11	days	day	NNS
cord-022353-q2k2krnm	459	12	without	without	IN
cord-022353-q2k2krnm	459	13	adverse	adverse	JJ
cord-022353-q2k2krnm	459	14	effect	effect	NN
cord-022353-q2k2krnm	459	15	on	on	IN
cord-022353-q2k2krnm	459	16	measurements	measurement	NNS
cord-022353-q2k2krnm	459	17	.	.	.
cord-022353-q2k2krnm	460	1	a.	a.	NN
cord-022353-q2k2krnm	460	2	SERUM	serum	NN
cord-022353-q2k2krnm	460	3	CHOLESTEROL	cholesterol	NN
cord-022353-q2k2krnm	460	4	AND	and	CC
cord-022353-q2k2krnm	460	5	TRIGLYCERIDES	triglycerides	NN
cord-022353-q2k2krnm	460	6	Serum	serum	NN
cord-022353-q2k2krnm	460	7	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	460	8	in	in	IN
cord-022353-q2k2krnm	460	9	mice	mouse	NNS
cord-022353-q2k2krnm	460	10	can	can	MD
cord-022353-q2k2krnm	460	11	be	be	VB
cord-022353-q2k2krnm	460	12	measured	measure	VBN
cord-022353-q2k2krnm	460	13	using	use	VBG
cord-022353-q2k2krnm	460	14	the	the	DT
cord-022353-q2k2krnm	460	15	enzymatic	enzymatic	JJ
cord-022353-q2k2krnm	460	16	oxidation	oxidation	NN
cord-022353-q2k2krnm	460	17	method	method	NN
cord-022353-q2k2krnm	460	18	of	of	IN
cord-022353-q2k2krnm	460	19	Roschlay	Roschlay	NNP
cord-022353-q2k2krnm	460	20	(	(	-LRB-
cord-022353-q2k2krnm	460	21	Meade	Meade	NNP
cord-022353-q2k2krnm	460	22	and	and	CC
cord-022353-q2k2krnm	460	23	Gore	Gore	NNP
cord-022353-q2k2krnm	460	24	1982	1982	CD
cord-022353-q2k2krnm	460	25	)	)	-RRB-
cord-022353-q2k2krnm	460	26	,	,	,
cord-022353-q2k2krnm	460	27	the	the	DT
cord-022353-q2k2krnm	460	28	Lipid	Lipid	NNP
cord-022353-q2k2krnm	460	29	Research	Research	NNP
cord-022353-q2k2krnm	460	30	Clinic	Clinic	NNP
cord-022353-q2k2krnm	460	31	Program	Program	NNP
cord-022353-q2k2krnm	460	32	protocol	protocol	NN
cord-022353-q2k2krnm	460	33	(	(	-LRB-
cord-022353-q2k2krnm	460	34	Morrisett	Morrisett	NNP
cord-022353-q2k2krnm	460	35	et	et	FW
cord-022353-q2k2krnm	460	36	al	al	NNP
cord-022353-q2k2krnm	460	37	.	.	.
cord-022353-q2k2krnm	460	38	1982	1982	CD
cord-022353-q2k2krnm	460	39	)	)	-RRB-
cord-022353-q2k2krnm	460	40	,	,	,
cord-022353-q2k2krnm	460	41	or	or	CC
cord-022353-q2k2krnm	460	42	the	the	DT
cord-022353-q2k2krnm	460	43	Abell	Abell	NNP
cord-022353-q2k2krnm	460	44	technique	technique	NN
cord-022353-q2k2krnm	460	45	(	(	-LRB-
cord-022353-q2k2krnm	460	46	Mitruka	Mitruka	NNP
cord-022353-q2k2krnm	460	47	and	and	CC
cord-022353-q2k2krnm	460	48	Rawnsley	Rawnsley	NNP
cord-022353-q2k2krnm	460	49	1977	1977	CD
cord-022353-q2k2krnm	460	50	)	)	-RRB-
cord-022353-q2k2krnm	460	51	.	.	.
cord-022353-q2k2krnm	461	1	The	the	DT
cord-022353-q2k2krnm	461	2	most	most	RBS
cord-022353-q2k2krnm	461	3	common	common	JJ
cord-022353-q2k2krnm	461	4	enzymatic	enzymatic	JJ
cord-022353-q2k2krnm	461	5	method	method	NN
cord-022353-q2k2krnm	461	6	employs	employ	VBZ
cord-022353-q2k2krnm	461	7	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	461	8	ester	ester	NNP
cord-022353-q2k2krnm	461	9	hydrolase	hydrolase	NNP
cord-022353-q2k2krnm	461	10	(	(	-LRB-
cord-022353-q2k2krnm	461	11	to	to	TO
cord-022353-q2k2krnm	461	12	convert	convert	VB
cord-022353-q2k2krnm	461	13	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	461	14	ester	ester	NN
cord-022353-q2k2krnm	461	15	to	to	IN
cord-022353-q2k2krnm	461	16	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	461	17	)	)	-RRB-
cord-022353-q2k2krnm	461	18	,	,	,
cord-022353-q2k2krnm	461	19	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	461	20	oxidase	oxidase	NN
cord-022353-q2k2krnm	461	21	(	(	-LRB-
cord-022353-q2k2krnm	461	22	which	which	WDT
cord-022353-q2k2krnm	461	23	oxidizes	oxidize	VBZ
cord-022353-q2k2krnm	461	24	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	461	25	to	to	IN
cord-022353-q2k2krnm	461	26	hydrogen	hydrogen	NN
cord-022353-q2k2krnm	461	27	peroxide	peroxide	NN
cord-022353-q2k2krnm	461	28	and	and	CC
cord-022353-q2k2krnm	461	29	cholest-4-en-3-one	cholest-4-en-3-one	NN
cord-022353-q2k2krnm	461	30	)	)	-RRB-
cord-022353-q2k2krnm	461	31	and	and	CC
cord-022353-q2k2krnm	461	32	peroxidase	peroxidase	NN
cord-022353-q2k2krnm	461	33	(	(	-LRB-
cord-022353-q2k2krnm	461	34	which	which	WDT
cord-022353-q2k2krnm	461	35	catalyzes	catalyze	VBZ
cord-022353-q2k2krnm	461	36	a	a	DT
cord-022353-q2k2krnm	461	37	reaction	reaction	NN
cord-022353-q2k2krnm	461	38	involving	involve	VBG
cord-022353-q2k2krnm	461	39	hydrogen	hydrogen	NN
cord-022353-q2k2krnm	461	40	peroxide	peroxide	NN
cord-022353-q2k2krnm	461	41	,	,	,
cord-022353-q2k2krnm	461	42	phenol	phenol	NN
cord-022353-q2k2krnm	461	43	and	and	CC
cord-022353-q2k2krnm	461	44	4-aminoantipyrine	4-aminoantipyrine	CD
cord-022353-q2k2krnm	461	45	to	to	TO
cord-022353-q2k2krnm	461	46	form	form	VB
cord-022353-q2k2krnm	461	47	the	the	DT
cord-022353-q2k2krnm	461	48	dye	dye	NN
cord-022353-q2k2krnm	461	49	quinonelmine	quinonelmine	NN
cord-022353-q2k2krnm	461	50	)	)	-RRB-
cord-022353-q2k2krnm	461	51	.	.	.
cord-022353-q2k2krnm	462	1	All	all	DT
cord-022353-q2k2krnm	462	2	of	of	IN
cord-022353-q2k2krnm	462	3	these	these	DT
cord-022353-q2k2krnm	462	4	components	component	NNS
cord-022353-q2k2krnm	462	5	of	of	IN
cord-022353-q2k2krnm	462	6	this	this	DT
cord-022353-q2k2krnm	462	7	test	test	NN
cord-022353-q2k2krnm	462	8	are	be	VBP
cord-022353-q2k2krnm	462	9	combined	combine	VBN
cord-022353-q2k2krnm	462	10	in	in	IN
cord-022353-q2k2krnm	462	11	a	a	DT
cord-022353-q2k2krnm	462	12	single	single	JJ
cord-022353-q2k2krnm	462	13	reagent	reagent	NN
cord-022353-q2k2krnm	462	14	mix	mix	NN
cord-022353-q2k2krnm	462	15	.	.	.
cord-022353-q2k2krnm	463	1	The	the	DT
cord-022353-q2k2krnm	463	2	dye	dye	NN
cord-022353-q2k2krnm	463	3	absorbance	absorbance	NN
cord-022353-q2k2krnm	463	4	is	be	VBZ
cord-022353-q2k2krnm	463	5	measured	measure	VBN
cord-022353-q2k2krnm	463	6	at	at	IN
cord-022353-q2k2krnm	463	7	500	500	CD
cord-022353-q2k2krnm	463	8	nm	nm	NN
cord-022353-q2k2krnm	463	9	(	(	-LRB-
cord-022353-q2k2krnm	463	10	Choudhury	Choudhury	NNP
cord-022353-q2k2krnm	463	11	et	et	NNP
cord-022353-q2k2krnm	463	12	al	al	NNP
cord-022353-q2k2krnm	463	13	.	.	.
cord-022353-q2k2krnm	463	14	2004	2004	CD
cord-022353-q2k2krnm	463	15	)	)	-RRB-
cord-022353-q2k2krnm	463	16	.	.	.
cord-022353-q2k2krnm	464	1	Triglyceride	triglyceride	NN
cord-022353-q2k2krnm	464	2	(	(	-LRB-
cord-022353-q2k2krnm	464	3	TG	TG	NNP
cord-022353-q2k2krnm	464	4	)	)	-RRB-
cord-022353-q2k2krnm	464	5	levels	level	NNS
cord-022353-q2k2krnm	464	6	,	,	,
cord-022353-q2k2krnm	464	7	which	which	WDT
cord-022353-q2k2krnm	464	8	are	be	VBP
cord-022353-q2k2krnm	464	9	mainly	mainly	RB
cord-022353-q2k2krnm	464	10	reflective	reflective	JJ
cord-022353-q2k2krnm	464	11	of	of	IN
cord-022353-q2k2krnm	464	12	the	the	DT
cord-022353-q2k2krnm	464	13	TG	TG	NNP
cord-022353-q2k2krnm	464	14	content	content	NN
cord-022353-q2k2krnm	464	15	of	of	IN
cord-022353-q2k2krnm	464	16	chylomicrons	chylomicron	NNS
cord-022353-q2k2krnm	464	17	and	and	CC
cord-022353-q2k2krnm	464	18	VLDL	vldl	NN
cord-022353-q2k2krnm	464	19	in	in	IN
cord-022353-q2k2krnm	464	20	the	the	DT
cord-022353-q2k2krnm	464	21	mouse	mouse	NN
cord-022353-q2k2krnm	464	22	,	,	,
cord-022353-q2k2krnm	464	23	are	be	VBP
cord-022353-q2k2krnm	464	24	quantified	quantify	VBN
cord-022353-q2k2krnm	464	25	using	use	VBG
cord-022353-q2k2krnm	464	26	a	a	DT
cord-022353-q2k2krnm	464	27	variety	variety	NN
cord-022353-q2k2krnm	464	28	of	of	IN
cord-022353-q2k2krnm	464	29	enzymatic	enzymatic	JJ
cord-022353-q2k2krnm	464	30	methods	method	NNS
cord-022353-q2k2krnm	464	31	.	.	.
cord-022353-q2k2krnm	465	1	The	the	DT
cord-022353-q2k2krnm	465	2	most	most	RBS
cord-022353-q2k2krnm	465	3	popular	popular	JJ
cord-022353-q2k2krnm	465	4	method	method	NN
cord-022353-q2k2krnm	465	5	combines	combine	VBZ
cord-022353-q2k2krnm	465	6	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	465	7	lipase	lipase	NN
cord-022353-q2k2krnm	465	8	,	,	,
cord-022353-q2k2krnm	465	9	glycerol	glycerol	NN
cord-022353-q2k2krnm	465	10	kinase	kinase	NN
cord-022353-q2k2krnm	465	11	,	,	,
cord-022353-q2k2krnm	465	12	and	and	CC
cord-022353-q2k2krnm	465	13	glycerol	glycerol	NN
cord-022353-q2k2krnm	465	14	-	-	HYPH
cord-022353-q2k2krnm	465	15	phosphate	phosphate	NN
cord-022353-q2k2krnm	465	16	oxidase	oxidase	NN
cord-022353-q2k2krnm	465	17	with	with	IN
cord-022353-q2k2krnm	465	18	peroxidase	peroxidase	NN
cord-022353-q2k2krnm	465	19	and	and	CC
cord-022353-q2k2krnm	465	20	4-aminoantipyrine	4-aminoantipyrine	CD
cord-022353-q2k2krnm	465	21	(	(	-LRB-
cord-022353-q2k2krnm	465	22	usually	usually	RB
cord-022353-q2k2krnm	465	23	in	in	IN
cord-022353-q2k2krnm	465	24	two	two	CD
cord-022353-q2k2krnm	465	25	reagents	reagent	NNS
cord-022353-q2k2krnm	465	26	)	)	-RRB-
cord-022353-q2k2krnm	465	27	.	.	.
cord-022353-q2k2krnm	466	1	In	in	IN
cord-022353-q2k2krnm	466	2	this	this	DT
cord-022353-q2k2krnm	466	3	method	method	NN
cord-022353-q2k2krnm	466	4	,	,	,
cord-022353-q2k2krnm	466	5	serum	serum	NN
cord-022353-q2k2krnm	466	6	TGs	tg	NNS
cord-022353-q2k2krnm	466	7	are	be	VBP
cord-022353-q2k2krnm	466	8	converted	convert	VBN
cord-022353-q2k2krnm	466	9	to	to	IN
cord-022353-q2k2krnm	466	10	glycerol	glycerol	NN
cord-022353-q2k2krnm	466	11	by	by	IN
cord-022353-q2k2krnm	466	12	LPL	LPL	NNP
cord-022353-q2k2krnm	466	13	via	via	IN
cord-022353-q2k2krnm	466	14	hydrolysis	hydrolysis	NN
cord-022353-q2k2krnm	466	15	.	.	.
cord-022353-q2k2krnm	467	1	Next	next	RB
cord-022353-q2k2krnm	467	2	the	the	DT
cord-022353-q2k2krnm	467	3	glycerol	glycerol	NN
cord-022353-q2k2krnm	467	4	is	be	VBZ
cord-022353-q2k2krnm	467	5	phosphorylated	phosphorylate	VBN
cord-022353-q2k2krnm	467	6	in	in	IN
cord-022353-q2k2krnm	467	7	an	an	DT
cord-022353-q2k2krnm	467	8	ATP	ATP	NNP
cord-022353-q2k2krnm	467	9	-	-	HYPH
cord-022353-q2k2krnm	467	10	dependent	dependent	JJ
cord-022353-q2k2krnm	467	11	reaction	reaction	NN
cord-022353-q2k2krnm	467	12	catalyzed	catalyze	VBN
cord-022353-q2k2krnm	467	13	by	by	IN
cord-022353-q2k2krnm	467	14	glycerol	glycerol	NN
cord-022353-q2k2krnm	467	15	kinase	kinase	NN
cord-022353-q2k2krnm	467	16	.	.	.
cord-022353-q2k2krnm	468	1	Glycerol	glycerol	NN
cord-022353-q2k2krnm	468	2	-	-	HYPH
cord-022353-q2k2krnm	468	3	phosphate	phosphate	NN
cord-022353-q2k2krnm	468	4	is	be	VBZ
cord-022353-q2k2krnm	468	5	catalyzed	catalyze	VBN
cord-022353-q2k2krnm	468	6	to	to	IN
cord-022353-q2k2krnm	468	7	dihydroxyacetone	dihydroxyacetone	NN
cord-022353-q2k2krnm	468	8	and	and	CC
cord-022353-q2k2krnm	468	9	hydrogen	hydrogen	NN
cord-022353-q2k2krnm	468	10	peroxide	peroxide	NN
cord-022353-q2k2krnm	468	11	by	by	IN
cord-022353-q2k2krnm	468	12	glycerophosphate	glycerophosphate	NN
cord-022353-q2k2krnm	468	13	oxidase	oxidase	NN
cord-022353-q2k2krnm	468	14	and	and	CC
cord-022353-q2k2krnm	468	15	peroxidase	peroxidase	NN
cord-022353-q2k2krnm	469	1	catalyzes	catalyze	VBZ
cord-022353-q2k2krnm	469	2	the	the	DT
cord-022353-q2k2krnm	469	3	final	final	JJ
cord-022353-q2k2krnm	469	4	reaction	reaction	NN
cord-022353-q2k2krnm	469	5	in	in	IN
cord-022353-q2k2krnm	469	6	which	which	WDT
cord-022353-q2k2krnm	469	7	peroxide	peroxide	NN
cord-022353-q2k2krnm	469	8	and	and	CC
cord-022353-q2k2krnm	469	9	4-aminoantipyrine	4-aminoantipyrine	CD
cord-022353-q2k2krnm	469	10	are	be	VBP
cord-022353-q2k2krnm	469	11	converted	convert	VBN
cord-022353-q2k2krnm	469	12	to	to	IN
cord-022353-q2k2krnm	469	13	a	a	DT
cord-022353-q2k2krnm	469	14	stable	stable	JJ
cord-022353-q2k2krnm	469	15	dye	dye	NN
cord-022353-q2k2krnm	469	16	and	and	CC
cord-022353-q2k2krnm	469	17	absorbance	absorbance	NN
cord-022353-q2k2krnm	469	18	can	can	MD
cord-022353-q2k2krnm	469	19	be	be	VB
cord-022353-q2k2krnm	469	20	read	read	VBN
cord-022353-q2k2krnm	469	21	at	at	IN
cord-022353-q2k2krnm	469	22	500	500	CD
cord-022353-q2k2krnm	469	23	nm	nm	NN
cord-022353-q2k2krnm	469	24	(	(	-LRB-
cord-022353-q2k2krnm	469	25	Tsimikas	Tsimikas	NNP
cord-022353-q2k2krnm	469	26	et	et	FW
cord-022353-q2k2krnm	469	27	al	al	NNP
cord-022353-q2k2krnm	469	28	.	.	.
cord-022353-q2k2krnm	469	29	2000	2000	CD
cord-022353-q2k2krnm	469	30	)	)	-RRB-
cord-022353-q2k2krnm	469	31	.	.	.
cord-022353-q2k2krnm	470	1	Reagents	reagent	NNS
cord-022353-q2k2krnm	470	2	for	for	IN
cord-022353-q2k2krnm	470	3	both	both	DT
cord-022353-q2k2krnm	470	4	total	total	JJ
cord-022353-q2k2krnm	470	5	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	470	6	and	and	CC
cord-022353-q2k2krnm	470	7	total	total	JJ
cord-022353-q2k2krnm	470	8	TGs	tg	NNS
cord-022353-q2k2krnm	470	9	may	may	MD
cord-022353-q2k2krnm	470	10	be	be	VB
cord-022353-q2k2krnm	470	11	used	use	VBN
cord-022353-q2k2krnm	470	12	in	in	IN
cord-022353-q2k2krnm	470	13	an	an	DT
cord-022353-q2k2krnm	470	14	automated	automated	JJ
cord-022353-q2k2krnm	470	15	analyzer	analyzer	NN
cord-022353-q2k2krnm	470	16	or	or	CC
cord-022353-q2k2krnm	470	17	purchased	purchase	VBN
cord-022353-q2k2krnm	470	18	directly	directly	RB
cord-022353-q2k2krnm	470	19	from	from	IN
cord-022353-q2k2krnm	470	20	a	a	DT
cord-022353-q2k2krnm	470	21	chemical	chemical	JJ
cord-022353-q2k2krnm	470	22	company	company	NN
cord-022353-q2k2krnm	470	23	with	with	IN
cord-022353-q2k2krnm	470	24	instructions	instruction	NNS
cord-022353-q2k2krnm	470	25	for	for	IN
cord-022353-q2k2krnm	470	26	manual	manual	JJ
cord-022353-q2k2krnm	470	27	laboratory	laboratory	NN
cord-022353-q2k2krnm	470	28	analysis	analysis	NN
cord-022353-q2k2krnm	470	29	.	.	.
cord-022353-q2k2krnm	471	1	Total	total	JJ
cord-022353-q2k2krnm	471	2	serum	serum	NN
cord-022353-q2k2krnm	471	3	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	471	4	and	and	CC
cord-022353-q2k2krnm	471	5	TG	TG	NNP
cord-022353-q2k2krnm	471	6	levels	level	NNS
cord-022353-q2k2krnm	471	7	vary	vary	VBP
cord-022353-q2k2krnm	471	8	by	by	IN
cord-022353-q2k2krnm	471	9	strain	strain	NN
cord-022353-q2k2krnm	471	10	,	,	,
cord-022353-q2k2krnm	471	11	gender	gender	NN
cord-022353-q2k2krnm	471	12	,	,	,
cord-022353-q2k2krnm	471	13	age	age	NN
cord-022353-q2k2krnm	471	14	,	,	,
cord-022353-q2k2krnm	471	15	length	length	NN
cord-022353-q2k2krnm	471	16	of	of	IN
cord-022353-q2k2krnm	471	17	fast	fast	JJ
cord-022353-q2k2krnm	471	18	,	,	,
cord-022353-q2k2krnm	471	19	and	and	CC
cord-022353-q2k2krnm	471	20	diet	diet	NN
cord-022353-q2k2krnm	471	21	.	.	.
cord-022353-q2k2krnm	472	1	Jiao	Jiao	NNP
cord-022353-q2k2krnm	472	2	et	et	NNP
cord-022353-q2k2krnm	472	3	al	al	NNP
cord-022353-q2k2krnm	472	4	.	.	.
cord-022353-q2k2krnm	473	1	(	(	-LRB-
cord-022353-q2k2krnm	473	2	1990	1990	CD
cord-022353-q2k2krnm	473	3	)	)	-RRB-
cord-022353-q2k2krnm	473	4	studied	study	VBD
cord-022353-q2k2krnm	473	5	total	total	JJ
cord-022353-q2k2krnm	473	6	plasma	plasma	NN
cord-022353-q2k2krnm	473	7	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	473	8	(	(	-LRB-
cord-022353-q2k2krnm	473	9	TPC	TPC	NNP
cord-022353-q2k2krnm	473	10	)	)	-RRB-
cord-022353-q2k2krnm	473	11	and	and	CC
cord-022353-q2k2krnm	473	12	TG	TG	NNP
cord-022353-q2k2krnm	473	13	levels	level	NNS
cord-022353-q2k2krnm	473	14	of	of	IN
cord-022353-q2k2krnm	473	15	various	various	JJ
cord-022353-q2k2krnm	473	16	inbred	inbred	JJ
cord-022353-q2k2krnm	473	17	strains	strain	NNS
cord-022353-q2k2krnm	473	18	fed	feed	VBD
cord-022353-q2k2krnm	473	19	a	a	DT
cord-022353-q2k2krnm	473	20	standard	standard	JJ
cord-022353-q2k2krnm	473	21	diet	diet	NN
cord-022353-q2k2krnm	473	22	.	.	.
cord-022353-q2k2krnm	474	1	After	after	IN
cord-022353-q2k2krnm	474	2	18	18	CD
cord-022353-q2k2krnm	474	3	-	-	SYM
cord-022353-q2k2krnm	474	4	20	20	CD
cord-022353-q2k2krnm	474	5	h	h	NN
cord-022353-q2k2krnm	474	6	of	of	IN
cord-022353-q2k2krnm	474	7	fasting	fasting	NN
cord-022353-q2k2krnm	474	8	,	,	,
cord-022353-q2k2krnm	474	9	TPC	TPC	NNP
cord-022353-q2k2krnm	474	10	levels	level	NNS
cord-022353-q2k2krnm	474	11	ranged	range	VBD
cord-022353-q2k2krnm	474	12	from	from	IN
cord-022353-q2k2krnm	474	13	55	55	CD
cord-022353-q2k2krnm	474	14	mg	mg	NNP
cord-022353-q2k2krnm	474	15	/	/	SYM
cord-022353-q2k2krnm	474	16	dl	dl	NNP
cord-022353-q2k2krnm	474	17	(	(	-LRB-
cord-022353-q2k2krnm	474	18	AKR	AKR	NNP
cord-022353-q2k2krnm	474	19	/	/	SYM
cord-022353-q2k2krnm	474	20	J	J	NNP
cord-022353-q2k2krnm	474	21	)	)	-RRB-
cord-022353-q2k2krnm	474	22	to	to	IN
cord-022353-q2k2krnm	474	23	128	128	CD
cord-022353-q2k2krnm	474	24	mg	mg	NNP
cord-022353-q2k2krnm	474	25	/	/	SYM
cord-022353-q2k2krnm	474	26	dl	dl	NNP
cord-022353-q2k2krnm	474	27	(	(	-LRB-
cord-022353-q2k2krnm	474	28	NZB	NZB	NNP
cord-022353-q2k2krnm	474	29	/	/	SYM
cord-022353-q2k2krnm	474	30	B	B	NNP
cord-022353-q2k2krnm	474	31	1NJ	1nj	CD
cord-022353-q2k2krnm	474	32	)	)	-RRB-
cord-022353-q2k2krnm	474	33	,	,	,
cord-022353-q2k2krnm	474	34	and	and	CC
cord-022353-q2k2krnm	474	35	TG	TG	NNP
cord-022353-q2k2krnm	474	36	levels	level	NNS
cord-022353-q2k2krnm	474	37	ranged	range	VBD
cord-022353-q2k2krnm	474	38	from	from	IN
cord-022353-q2k2krnm	474	39	13	13	CD
cord-022353-q2k2krnm	474	40	mg	mg	NNP
cord-022353-q2k2krnm	474	41	/	/	SYM
cord-022353-q2k2krnm	474	42	dl	dl	NNP
cord-022353-q2k2krnm	474	43	(	(	-LRB-
cord-022353-q2k2krnm	474	44	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	474	45	)	)	-RRB-
cord-022353-q2k2krnm	474	46	to	to	IN
cord-022353-q2k2krnm	474	47	67	67	CD
cord-022353-q2k2krnm	474	48	mg	mg	NNP
cord-022353-q2k2krnm	474	49	/	/	SYM
cord-022353-q2k2krnm	474	50	dl	dl	NNP
cord-022353-q2k2krnm	474	51	C3H	C3H	NNP
cord-022353-q2k2krnm	474	52	/	/	SYM
cord-022353-q2k2krnm	474	53	HeJ	HeJ	NNP
cord-022353-q2k2krnm	474	54	;	;	:
cord-022353-q2k2krnm	474	55	each	each	DT
cord-022353-q2k2krnm	474	56	much	much	RB
cord-022353-q2k2krnm	474	57	lower	low	JJR
cord-022353-q2k2krnm	474	58	than	than	IN
cord-022353-q2k2krnm	474	59	seen	see	VBN
cord-022353-q2k2krnm	474	60	in	in	IN
cord-022353-q2k2krnm	474	61	normal	normal	JJ
cord-022353-q2k2krnm	474	62	humans	human	NNS
cord-022353-q2k2krnm	474	63	.	.	.
cord-022353-q2k2krnm	475	1	Albers	Albers	NNP
cord-022353-q2k2krnm	475	2	and	and	CC
cord-022353-q2k2krnm	475	3	Piagen	Piagen	NNP
cord-022353-q2k2krnm	475	4	(	(	-LRB-
cord-022353-q2k2krnm	475	5	1999	1999	CD
cord-022353-q2k2krnm	475	6	)	)	-RRB-
cord-022353-q2k2krnm	475	7	quantified	quantify	VBD
cord-022353-q2k2krnm	475	8	total	total	JJ
cord-022353-q2k2krnm	475	9	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	475	10	levels	level	NNS
cord-022353-q2k2krnm	475	11	in	in	IN
cord-022353-q2k2krnm	475	12	15	15	CD
cord-022353-q2k2krnm	475	13	strains	strain	NNS
cord-022353-q2k2krnm	475	14	give	give	VBP
cord-022353-q2k2krnm	475	15	a	a	DT
cord-022353-q2k2krnm	475	16	standard	standard	JJ
cord-022353-q2k2krnm	475	17	laboratory	laboratory	NN
cord-022353-q2k2krnm	475	18	diet	diet	NN
cord-022353-q2k2krnm	475	19	and	and	CC
cord-022353-q2k2krnm	475	20	fasted	fast	VBD
cord-022353-q2k2krnm	475	21	for	for	IN
cord-022353-q2k2krnm	475	22	4	4	CD
cord-022353-q2k2krnm	475	23	h	h	NN
cord-022353-q2k2krnm	475	24	before	before	IN
cord-022353-q2k2krnm	475	25	blood	blood	NN
cord-022353-q2k2krnm	475	26	collection	collection	NN
cord-022353-q2k2krnm	475	27	.	.	.
cord-022353-q2k2krnm	476	1	Levels	level	NNS
cord-022353-q2k2krnm	476	2	(	(	-LRB-
cord-022353-q2k2krnm	476	3	in	in	IN
cord-022353-q2k2krnm	476	4	6-to	6-to	CD
cord-022353-q2k2krnm	476	5	8-week	8-week	CD
cord-022353-q2k2krnm	476	6	-	-	HYPH
cord-022353-q2k2krnm	476	7	old	old	JJ
cord-022353-q2k2krnm	476	8	mice	mouse	NNS
cord-022353-q2k2krnm	476	9	)	)	-RRB-
cord-022353-q2k2krnm	476	10	varied	vary	VBN
cord-022353-q2k2krnm	476	11	greatly	greatly	RB
cord-022353-q2k2krnm	476	12	between	between	IN
cord-022353-q2k2krnm	476	13	strains	strain	NNS
cord-022353-q2k2krnm	476	14	with	with	IN
cord-022353-q2k2krnm	476	15	C57BLKS	C57BLKS	NNP
cord-022353-q2k2krnm	476	16	/	/	SYM
cord-022353-q2k2krnm	476	17	J	J	NNP
cord-022353-q2k2krnm	476	18	females	female	NNS
cord-022353-q2k2krnm	476	19	having	have	VBG
cord-022353-q2k2krnm	476	20	the	the	DT
cord-022353-q2k2krnm	476	21	lowest	low	JJS
cord-022353-q2k2krnm	476	22	level	level	NN
cord-022353-q2k2krnm	476	23	(	(	-LRB-
cord-022353-q2k2krnm	476	24	39	39	CD
cord-022353-q2k2krnm	476	25	mg	mg	NNP
cord-022353-q2k2krnm	476	26	/	/	SYM
cord-022353-q2k2krnm	476	27	dl	dl	NNP
cord-022353-q2k2krnm	476	28	)	)	-RRB-
cord-022353-q2k2krnm	476	29	and	and	CC
cord-022353-q2k2krnm	476	30	NZB	NZB	NNP
cord-022353-q2k2krnm	476	31	/	/	SYM
cord-022353-q2k2krnm	476	32	B	b	NN
cord-022353-q2k2krnm	476	33	1NJ	1nj	CD
cord-022353-q2k2krnm	476	34	males	male	NNS
cord-022353-q2k2krnm	476	35	having	have	VBG
cord-022353-q2k2krnm	476	36	the	the	DT
cord-022353-q2k2krnm	476	37	highest	high	JJS
cord-022353-q2k2krnm	476	38	levels	level	NNS
cord-022353-q2k2krnm	476	39	(	(	-LRB-
cord-022353-q2k2krnm	476	40	127	127	CD
cord-022353-q2k2krnm	476	41	mg	mg	NNP
cord-022353-q2k2krnm	476	42	/	/	SYM
cord-022353-q2k2krnm	476	43	dl	dl	NNP
cord-022353-q2k2krnm	476	44	)	)	-RRB-
cord-022353-q2k2krnm	476	45	.	.	.
cord-022353-q2k2krnm	477	1	For	for	IN
cord-022353-q2k2krnm	477	2	a	a	DT
cord-022353-q2k2krnm	477	3	given	give	VBN
cord-022353-q2k2krnm	477	4	strain	strain	NN
cord-022353-q2k2krnm	477	5	,	,	,
cord-022353-q2k2krnm	477	6	males	male	NNS
cord-022353-q2k2krnm	477	7	always	always	RB
cord-022353-q2k2krnm	477	8	had	have	VBD
cord-022353-q2k2krnm	477	9	higher	high	JJR
cord-022353-q2k2krnm	477	10	levels	level	NNS
cord-022353-q2k2krnm	477	11	than	than	IN
cord-022353-q2k2krnm	477	12	females	female	NNS
cord-022353-q2k2krnm	477	13	.	.	.
cord-022353-q2k2krnm	478	1	Trends	trend	NNS
cord-022353-q2k2krnm	478	2	in	in	IN
cord-022353-q2k2krnm	478	3	total	total	JJ
cord-022353-q2k2krnm	478	4	HDL	HDL	NNP
cord-022353-q2k2krnm	478	5	levels	level	NNS
cord-022353-q2k2krnm	478	6	in	in	IN
cord-022353-q2k2krnm	478	7	the	the	DT
cord-022353-q2k2krnm	478	8	same	same	JJ
cord-022353-q2k2krnm	478	9	strains	strain	NNS
cord-022353-q2k2krnm	478	10	paralleled	parallel	VBD
cord-022353-q2k2krnm	478	11	total	total	JJ
cord-022353-q2k2krnm	478	12	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	478	13	levels	level	NNS
cord-022353-q2k2krnm	478	14	.	.	.
cord-022353-q2k2krnm	479	1	Triglyceride	triglyceride	NN
cord-022353-q2k2krnm	479	2	levels	level	NNS
cord-022353-q2k2krnm	479	3	also	also	RB
cord-022353-q2k2krnm	479	4	varied	vary	VBD
cord-022353-q2k2krnm	479	5	greatly	greatly	RB
cord-022353-q2k2krnm	479	6	among	among	IN
cord-022353-q2k2krnm	479	7	strains	strain	NNS
cord-022353-q2k2krnm	479	8	but	but	CC
cord-022353-q2k2krnm	479	9	did	do	VBD
cord-022353-q2k2krnm	479	10	not	not	RB
cord-022353-q2k2krnm	479	11	parallel	parallel	VB
cord-022353-q2k2krnm	479	12	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	479	13	levels	level	NNS
cord-022353-q2k2krnm	479	14	.	.	.
cord-022353-q2k2krnm	480	1	Among	among	IN
cord-022353-q2k2krnm	480	2	the	the	DT
cord-022353-q2k2krnm	480	3	strains	strain	NNS
cord-022353-q2k2krnm	480	4	tested	test	VBN
cord-022353-q2k2krnm	480	5	,	,	,
cord-022353-q2k2krnm	480	6	C57BL/6J	C57BL/6J	NNP
cord-022353-q2k2krnm	480	7	mice	mouse	NNS
cord-022353-q2k2krnm	480	8	had	have	VBD
cord-022353-q2k2krnm	480	9	the	the	DT
cord-022353-q2k2krnm	480	10	lowest	low	JJS
cord-022353-q2k2krnm	480	11	TG	TG	NNP
cord-022353-q2k2krnm	480	12	levels	level	NNS
cord-022353-q2k2krnm	480	13	(	(	-LRB-
cord-022353-q2k2krnm	480	14	71	71	CD
cord-022353-q2k2krnm	480	15	-	-	SYM
cord-022353-q2k2krnm	480	16	80	80	CD
cord-022353-q2k2krnm	480	17	mg	mg	NNP
cord-022353-q2k2krnm	480	18	/	/	SYM
cord-022353-q2k2krnm	480	19	dl	dl	NNP
cord-022353-q2k2krnm	480	20	)	)	-RRB-
cord-022353-q2k2krnm	480	21	and	and	CC
cord-022353-q2k2krnm	480	22	C3H	c3h	RB
cord-022353-q2k2krnm	480	23	/	/	SYM
cord-022353-q2k2krnm	480	24	HeSnJ	HeSnJ	NNP
cord-022353-q2k2krnm	480	25	the	the	DT
cord-022353-q2k2krnm	480	26	highest	high	JJS
cord-022353-q2k2krnm	480	27	(	(	-LRB-
cord-022353-q2k2krnm	480	28	F	F	NNP
cord-022353-q2k2krnm	480	29	,	,	,
cord-022353-q2k2krnm	480	30	162	162	CD
cord-022353-q2k2krnm	480	31	mg	mg	NNP
cord-022353-q2k2krnm	480	32	/	/	SYM
cord-022353-q2k2krnm	480	33	dl	dl	NN
cord-022353-q2k2krnm	480	34	;	;	:
cord-022353-q2k2krnm	481	1	M	M	NNP
cord-022353-q2k2krnm	481	2	,	,	,
cord-022353-q2k2krnm	481	3	231	231	CD
cord-022353-q2k2krnm	481	4	mg	mg	NNP
cord-022353-q2k2krnm	481	5	/	/	SYM
cord-022353-q2k2krnm	481	6	dl	dl	NNP
cord-022353-q2k2krnm	481	7	)	)	-RRB-
cord-022353-q2k2krnm	481	8	.	.	.
cord-022353-q2k2krnm	482	1	Differences	difference	NNS
cord-022353-q2k2krnm	482	2	between	between	IN
cord-022353-q2k2krnm	482	3	genders	gender	NNS
cord-022353-q2k2krnm	482	4	of	of	IN
cord-022353-q2k2krnm	482	5	the	the	DT
cord-022353-q2k2krnm	482	6	same	same	JJ
cord-022353-q2k2krnm	482	7	strain	strain	NN
cord-022353-q2k2krnm	482	8	were	be	VBD
cord-022353-q2k2krnm	482	9	less	less	RBR
cord-022353-q2k2krnm	482	10	pronounced	pronounce	VBN
cord-022353-q2k2krnm	482	11	,	,	,
cord-022353-q2k2krnm	482	12	compared	compare	VBN
cord-022353-q2k2krnm	482	13	to	to	IN
cord-022353-q2k2krnm	482	14	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	482	15	and	and	CC
cord-022353-q2k2krnm	482	16	males	male	NNS
cord-022353-q2k2krnm	482	17	generally	generally	RB
cord-022353-q2k2krnm	482	18	had	have	VBD
cord-022353-q2k2krnm	482	19	higher	high	JJR
cord-022353-q2k2krnm	482	20	levels	level	NNS
cord-022353-q2k2krnm	482	21	than	than	IN
cord-022353-q2k2krnm	482	22	females	female	NNS
cord-022353-q2k2krnm	482	23	.	.	.
cord-022353-q2k2krnm	483	1	A	a	DT
cord-022353-q2k2krnm	483	2	transient	transient	JJ
cord-022353-q2k2krnm	483	3	cause	cause	NN
cord-022353-q2k2krnm	483	4	of	of	IN
cord-022353-q2k2krnm	483	5	plasma	plasma	NN
cord-022353-q2k2krnm	483	6	lipid	lipid	NN
cord-022353-q2k2krnm	483	7	elevation	elevation	NN
cord-022353-q2k2krnm	483	8	(	(	-LRB-
cord-022353-q2k2krnm	483	9	hyperlipidemia	hyperlipidemia	NN
cord-022353-q2k2krnm	483	10	)	)	-RRB-
cord-022353-q2k2krnm	483	11	in	in	IN
cord-022353-q2k2krnm	483	12	the	the	DT
cord-022353-q2k2krnm	483	13	mouse	mouse	NN
cord-022353-q2k2krnm	483	14	is	be	VBZ
cord-022353-q2k2krnm	483	15	related	relate	VBN
cord-022353-q2k2krnm	483	16	to	to	IN
cord-022353-q2k2krnm	483	17	recent	recent	JJ
cord-022353-q2k2krnm	483	18	feeding	feeding	NN
cord-022353-q2k2krnm	483	19	(	(	-LRB-
cord-022353-q2k2krnm	483	20	postprandial	postprandial	JJ
cord-022353-q2k2krnm	483	21	hyperlipidemia	hyperlipidemia	NN
cord-022353-q2k2krnm	483	22	)	)	-RRB-
cord-022353-q2k2krnm	483	23	,	,	,
cord-022353-q2k2krnm	483	24	especially	especially	RB
cord-022353-q2k2krnm	483	25	on	on	IN
cord-022353-q2k2krnm	483	26	a	a	DT
cord-022353-q2k2krnm	483	27	high	high	JJ
cord-022353-q2k2krnm	483	28	-	-	HYPH
cord-022353-q2k2krnm	483	29	fat	fat	NN
cord-022353-q2k2krnm	483	30	diet	diet	NN
cord-022353-q2k2krnm	483	31	.	.	.
cord-022353-q2k2krnm	484	1	Causes	cause	NNS
cord-022353-q2k2krnm	484	2	of	of	IN
cord-022353-q2k2krnm	484	3	persistent	persistent	JJ
cord-022353-q2k2krnm	484	4	hyperlipidemia	hyperlipidemia	NN
cord-022353-q2k2krnm	484	5	include	include	VBP
cord-022353-q2k2krnm	484	6	diabetes	diabete	NNS
cord-022353-q2k2krnm	484	7	,	,	,
cord-022353-q2k2krnm	484	8	sustained	sustain	VBN
cord-022353-q2k2krnm	484	9	feeding	feeding	NN
cord-022353-q2k2krnm	484	10	of	of	IN
cord-022353-q2k2krnm	484	11	a	a	DT
cord-022353-q2k2krnm	484	12	high	high	JJ
cord-022353-q2k2krnm	484	13	-	-	HYPH
cord-022353-q2k2krnm	484	14	fat	fat	NN
cord-022353-q2k2krnm	484	15	diet	diet	NN
cord-022353-q2k2krnm	484	16	,	,	,
cord-022353-q2k2krnm	484	17	and	and	CC
cord-022353-q2k2krnm	484	18	nephrotic	nephrotic	JJ
cord-022353-q2k2krnm	484	19	syndrome	syndrome	NN
cord-022353-q2k2krnm	484	20	.	.	.
cord-022353-q2k2krnm	485	1	b.	b.	NNP
cord-022353-q2k2krnm	485	2	HDL	HDL	NNP
cord-022353-q2k2krnm	485	3	,	,	,
cord-022353-q2k2krnm	485	4	LDL	LDL	NNP
cord-022353-q2k2krnm	485	5	,	,	,
cord-022353-q2k2krnm	485	6	IDL	IDL	NNP
cord-022353-q2k2krnm	485	7	,	,	,
cord-022353-q2k2krnm	485	8	AND	and	CC
cord-022353-q2k2krnm	485	9	VLDL	VLDL	NNP
cord-022353-q2k2krnm	485	10	Levels	level	NNS
cord-022353-q2k2krnm	485	11	of	of	IN
cord-022353-q2k2krnm	485	12	individual	individual	JJ
cord-022353-q2k2krnm	485	13	apolipoproteins	apolipoprotein	NNS
cord-022353-q2k2krnm	485	14	can	can	MD
cord-022353-q2k2krnm	485	15	be	be	VB
cord-022353-q2k2krnm	485	16	measured	measure	VBN
cord-022353-q2k2krnm	485	17	by	by	IN
cord-022353-q2k2krnm	485	18	density	density	NN
cord-022353-q2k2krnm	485	19	gradient	gradient	NN
cord-022353-q2k2krnm	485	20	ultracentrifugation	ultracentrifugation	NN
cord-022353-q2k2krnm	485	21	combined	combine	VBN
cord-022353-q2k2krnm	485	22	with	with	IN
cord-022353-q2k2krnm	485	23	either	either	DT
cord-022353-q2k2krnm	485	24	electrophoretic	electrophoretic	JJ
cord-022353-q2k2krnm	485	25	,	,	,
cord-022353-q2k2krnm	485	26	immunologic	immunologic	JJ
cord-022353-q2k2krnm	485	27	,	,	,
cord-022353-q2k2krnm	485	28	chemical	chemical	NN
cord-022353-q2k2krnm	485	29	,	,	,
cord-022353-q2k2krnm	485	30	or	or	CC
cord-022353-q2k2krnm	485	31	morphologic	morphologic	JJ
cord-022353-q2k2krnm	485	32	analyses	analysis	NNS
cord-022353-q2k2krnm	485	33	.	.	.
cord-022353-q2k2krnm	486	1	Although	although	IN
cord-022353-q2k2krnm	486	2	published	publish	VBN
cord-022353-q2k2krnm	486	3	reference	reference	NN
cord-022353-q2k2krnm	486	4	ranges	range	NNS
cord-022353-q2k2krnm	486	5	are	be	VBP
cord-022353-q2k2krnm	486	6	not	not	RB
cord-022353-q2k2krnm	486	7	available	available	JJ
cord-022353-q2k2krnm	486	8	,	,	,
cord-022353-q2k2krnm	486	9	the	the	DT
cord-022353-q2k2krnm	486	10	distribution	distribution	NN
cord-022353-q2k2krnm	486	11	and	and	CC
cord-022353-q2k2krnm	486	12	characterization	characterization	NN
cord-022353-q2k2krnm	486	13	of	of	IN
cord-022353-q2k2krnm	486	14	murine	murine	JJ
cord-022353-q2k2krnm	486	15	apoproteins	apoprotein	NNS
cord-022353-q2k2krnm	486	16	has	have	VBZ
cord-022353-q2k2krnm	486	17	been	be	VBN
cord-022353-q2k2krnm	486	18	reported	report	VBN
cord-022353-q2k2krnm	487	1	(	(	-LRB-
cord-022353-q2k2krnm	487	2	Camus	Camus	NNP
cord-022353-q2k2krnm	487	3	et	et	NNP
cord-022353-q2k2krnm	487	4	al	al	NNP
cord-022353-q2k2krnm	487	5	.	.	.
cord-022353-q2k2krnm	487	6	1983	1983	CD
cord-022353-q2k2krnm	487	7	)	)	-RRB-
cord-022353-q2k2krnm	487	8	.	.	.
cord-022353-q2k2krnm	488	1	Similar	similar	JJ
cord-022353-q2k2krnm	488	2	methods	method	NNS
cord-022353-q2k2krnm	488	3	were	be	VBD
cord-022353-q2k2krnm	488	4	used	use	VBN
cord-022353-q2k2krnm	488	5	to	to	TO
cord-022353-q2k2krnm	488	6	evaluate	evaluate	VB
cord-022353-q2k2krnm	488	7	plasma	plasma	NN
cord-022353-q2k2krnm	488	8	apoproteins	apoprotein	NNS
cord-022353-q2k2krnm	488	9	in	in	IN
cord-022353-q2k2krnm	488	10	mice	mouse	NNS
cord-022353-q2k2krnm	488	11	consuming	consume	VBG
cord-022353-q2k2krnm	488	12	atherogenic	atherogenic	JJ
cord-022353-q2k2krnm	488	13	diets	diet	NNS
cord-022353-q2k2krnm	488	14	(	(	-LRB-
cord-022353-q2k2krnm	488	15	MolTisett	MolTisett	NNP
cord-022353-q2k2krnm	488	16	et	et	FW
cord-022353-q2k2krnm	488	17	al	al	NNP
cord-022353-q2k2krnm	488	18	.	.	.
cord-022353-q2k2krnm	488	19	1982	1982	CD
cord-022353-q2k2krnm	488	20	)	)	-RRB-
cord-022353-q2k2krnm	488	21	.	.	.
cord-022353-q2k2krnm	489	1	More	more	RBR
cord-022353-q2k2krnm	489	2	recently	recently	RB
cord-022353-q2k2krnm	489	3	the	the	DT
cord-022353-q2k2krnm	489	4	profile	profile	NN
cord-022353-q2k2krnm	489	5	of	of	IN
cord-022353-q2k2krnm	489	6	murine	murine	JJ
cord-022353-q2k2krnm	489	7	plasma	plasma	NN
cord-022353-q2k2krnm	489	8	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	489	9	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	489	10	has	have	VBZ
cord-022353-q2k2krnm	489	11	been	be	VBN
cord-022353-q2k2krnm	489	12	determined	determine	VBN
cord-022353-q2k2krnm	489	13	by	by	IN
cord-022353-q2k2krnm	489	14	fast	fast	JJ
cord-022353-q2k2krnm	489	15	protein	protein	NN
cord-022353-q2k2krnm	489	16	liquid	liquid	NN
cord-022353-q2k2krnm	489	17	chromatography	chromatography	NN
cord-022353-q2k2krnm	489	18	with	with	IN
cord-022353-q2k2krnm	489	19	on	on	IN
cord-022353-q2k2krnm	489	20	-	-	HYPH
cord-022353-q2k2krnm	489	21	line	line	NN
cord-022353-q2k2krnm	489	22	post	post	JJ
cord-022353-q2k2krnm	489	23	-	-	JJ
cord-022353-q2k2krnm	489	24	column	column	JJ
cord-022353-q2k2krnm	489	25	analysis	analysis	NN
cord-022353-q2k2krnm	489	26	of	of	IN
cord-022353-q2k2krnm	489	27	Superose	Superose	NNP
cord-022353-q2k2krnm	489	28	6	6	CD
cord-022353-q2k2krnm	489	29	gel	gel	NN
cord-022353-q2k2krnm	489	30	-	-	HYPH
cord-022353-q2k2krnm	489	31	filtration	filtration	NN
cord-022353-q2k2krnm	489	32	eluates	eluate	NNS
cord-022353-q2k2krnm	489	33	(	(	-LRB-
cord-022353-q2k2krnm	489	34	Sehayek	Sehayek	NNP
cord-022353-q2k2krnm	489	35	et	et	NNP
cord-022353-q2k2krnm	489	36	al	al	NNP
cord-022353-q2k2krnm	489	37	.	.	NNP
cord-022353-q2k2krnm	489	38	2003	2003	CD
cord-022353-q2k2krnm	489	39	;	;	:
cord-022353-q2k2krnm	489	40	Strauss	Strauss	NNP
cord-022353-q2k2krnm	489	41	et	et	NNP
cord-022353-q2k2krnm	489	42	al	al	NNP
cord-022353-q2k2krnm	489	43	.	.	NNP
cord-022353-q2k2krnm	489	44	2001	2001	CD
cord-022353-q2k2krnm	489	45	)	)	-RRB-
cord-022353-q2k2krnm	489	46	.	.	.
cord-022353-q2k2krnm	490	1	In	in	IN
cord-022353-q2k2krnm	490	2	contrast	contrast	NN
cord-022353-q2k2krnm	490	3	to	to	IN
cord-022353-q2k2krnm	490	4	humans	human	NNS
cord-022353-q2k2krnm	490	5	,	,	,
cord-022353-q2k2krnm	490	6	mice	mouse	NNS
cord-022353-q2k2krnm	490	7	normally	normally	RB
cord-022353-q2k2krnm	490	8	have	have	VBP
cord-022353-q2k2krnm	490	9	low	low	JJ
cord-022353-q2k2krnm	490	10	levels	level	NNS
cord-022353-q2k2krnm	490	11	of	of	IN
cord-022353-q2k2krnm	490	12	LDL	ldl	NN
cord-022353-q2k2krnm	490	13	in	in	IN
cord-022353-q2k2krnm	490	14	their	-PRON-	PRP$
cord-022353-q2k2krnm	490	15	plasma	plasma	NN
cord-022353-q2k2krnm	490	16	(	(	-LRB-
cord-022353-q2k2krnm	490	17	15	15	CD
cord-022353-q2k2krnm	490	18	mg	mg	NNP
cord-022353-q2k2krnm	490	19	/	/	SYM
cord-022353-q2k2krnm	490	20	dl	dl	NNP
cord-022353-q2k2krnm	490	21	)	)	-RRB-
cord-022353-q2k2krnm	490	22	,	,	,
cord-022353-q2k2krnm	490	23	with	with	IN
cord-022353-q2k2krnm	490	24	the	the	DT
cord-022353-q2k2krnm	490	25	major	major	JJ
cord-022353-q2k2krnm	490	26	plasma	plasma	NN
cord-022353-q2k2krnm	490	27	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	490	28	being	be	VBG
cord-022353-q2k2krnm	490	29	HDL	HDL	NNP
cord-022353-q2k2krnm	490	30	.	.	.
cord-022353-q2k2krnm	491	1	The	the	DT
cord-022353-q2k2krnm	491	2	low	low	JJ
cord-022353-q2k2krnm	491	3	LDL	ldl	NN
cord-022353-q2k2krnm	491	4	concentration	concentration	NN
cord-022353-q2k2krnm	491	5	is	be	VBZ
cord-022353-q2k2krnm	491	6	due	due	JJ
cord-022353-q2k2krnm	491	7	to	to	IN
cord-022353-q2k2krnm	491	8	editing	editing	NN
cord-022353-q2k2krnm	491	9	of	of	IN
cord-022353-q2k2krnm	491	10	70	70	CD
cord-022353-q2k2krnm	491	11	%	%	NN
cord-022353-q2k2krnm	491	12	of	of	IN
cord-022353-q2k2krnm	491	13	apoprotein	apoprotein	NNP
cord-022353-q2k2krnm	491	14	B	B	NNP
cord-022353-q2k2krnm	491	15	mRNA	mRNA	NNP
cord-022353-q2k2krnm	491	16	transcripts	transcript	NNS
cord-022353-q2k2krnm	491	17	in	in	IN
cord-022353-q2k2krnm	491	18	mouse	mouse	NN
cord-022353-q2k2krnm	491	19	liver	liver	NN
cord-022353-q2k2krnm	491	20	leading	lead	VBG
cord-022353-q2k2krnm	491	21	to	to	TO
cord-022353-q2k2krnm	491	22	apoprotein	apoprotein	VB
cord-022353-q2k2krnm	491	23	B48	B48	NNP
cord-022353-q2k2krnm	491	24	containing	contain	VBG
cord-022353-q2k2krnm	491	25	particles	particle	NNS
cord-022353-q2k2krnm	491	26	that	that	WDT
cord-022353-q2k2krnm	491	27	are	be	VBP
cord-022353-q2k2krnm	491	28	cleared	clear	VBN
cord-022353-q2k2krnm	491	29	much	much	RB
cord-022353-q2k2krnm	491	30	faster	fast	RBR
cord-022353-q2k2krnm	491	31	than	than	IN
cord-022353-q2k2krnm	491	32	LDL	ldl	NN
cord-022353-q2k2krnm	491	33	in	in	IN
cord-022353-q2k2krnm	491	34	humans	human	NNS
cord-022353-q2k2krnm	491	35	(	(	-LRB-
cord-022353-q2k2krnm	491	36	Lusis	Lusis	NNP
cord-022353-q2k2krnm	491	37	2000	2000	CD
cord-022353-q2k2krnm	491	38	)	)	-RRB-
cord-022353-q2k2krnm	491	39	.	.	.
cord-022353-q2k2krnm	492	1	In	in	IN
cord-022353-q2k2krnm	492	2	contrast	contrast	NN
cord-022353-q2k2krnm	492	3	,	,	,
cord-022353-q2k2krnm	492	4	human	human	JJ
cord-022353-q2k2krnm	492	5	apoprotein	apoprotein	NNP
cord-022353-q2k2krnm	492	6	B	B	NNP
cord-022353-q2k2krnm	492	7	mRNA	mRNA	NNP
cord-022353-q2k2krnm	492	8	transcript	transcript	NN
cord-022353-q2k2krnm	492	9	editing	edit	VBG
cord-022353-q2k2krnm	492	10	only	only	RB
cord-022353-q2k2krnm	492	11	occurs	occur	VBZ
cord-022353-q2k2krnm	492	12	in	in	IN
cord-022353-q2k2krnm	492	13	the	the	DT
cord-022353-q2k2krnm	492	14	intestine	intestine	NN
cord-022353-q2k2krnm	492	15	.	.	.
cord-022353-q2k2krnm	493	1	A	a	DT
cord-022353-q2k2krnm	493	2	much	much	RB
cord-022353-q2k2krnm	493	3	simpler	simple	JJR
cord-022353-q2k2krnm	493	4	methodology	methodology	NN
cord-022353-q2k2krnm	493	5	has	have	VBZ
cord-022353-q2k2krnm	493	6	been	be	VBN
cord-022353-q2k2krnm	493	7	developed	develop	VBN
cord-022353-q2k2krnm	493	8	to	to	TO
cord-022353-q2k2krnm	493	9	measure	measure	VB
cord-022353-q2k2krnm	493	10	HDL	HDL	NNP
cord-022353-q2k2krnm	493	11	and	and	CC
cord-022353-q2k2krnm	493	12	non	non	JJ
cord-022353-q2k2krnm	493	13	-	-	JJ
cord-022353-q2k2krnm	493	14	HDL	hdl	JJ
cord-022353-q2k2krnm	493	15	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	493	16	in	in	IN
cord-022353-q2k2krnm	493	17	mice	mouse	NNS
cord-022353-q2k2krnm	493	18	,	,	,
cord-022353-q2k2krnm	493	19	based	base	VBN
cord-022353-q2k2krnm	493	20	on	on	IN
cord-022353-q2k2krnm	493	21	precipitation	precipitation	NN
cord-022353-q2k2krnm	493	22	and	and	CC
cord-022353-q2k2krnm	493	23	enzymatic	enzymatic	JJ
cord-022353-q2k2krnm	493	24	analysis	analysis	NN
cord-022353-q2k2krnm	493	25	.	.	.
cord-022353-q2k2krnm	494	1	When	when	WRB
cord-022353-q2k2krnm	494	2	phosphotungstate	phosphotungstate	JJ
cord-022353-q2k2krnm	494	3	and	and	CC
cord-022353-q2k2krnm	494	4	magnesium	magnesium	NN
cord-022353-q2k2krnm	494	5	salt	salt	NN
cord-022353-q2k2krnm	494	6	is	be	VBZ
cord-022353-q2k2krnm	494	7	added	add	VBN
cord-022353-q2k2krnm	494	8	to	to	IN
cord-022353-q2k2krnm	494	9	serum	serum	NN
cord-022353-q2k2krnm	494	10	(	(	-LRB-
cord-022353-q2k2krnm	494	11	or	or	CC
cord-022353-q2k2krnm	494	12	plasma	plasma	NN
cord-022353-q2k2krnm	494	13	)	)	-RRB-
cord-022353-q2k2krnm	494	14	,	,	,
cord-022353-q2k2krnm	494	15	all	all	DT
cord-022353-q2k2krnm	494	16	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	494	17	,	,	,
cord-022353-q2k2krnm	494	18	except	except	IN
cord-022353-q2k2krnm	494	19	HDL	HDL	NNP
cord-022353-q2k2krnm	494	20	,	,	,
cord-022353-q2k2krnm	494	21	is	be	VBZ
cord-022353-q2k2krnm	494	22	precipitated	precipitate	VBN
cord-022353-q2k2krnm	494	23	and	and	CC
cord-022353-q2k2krnm	494	24	can	can	MD
cord-022353-q2k2krnm	494	25	be	be	VB
cord-022353-q2k2krnm	494	26	removed	remove	VBN
cord-022353-q2k2krnm	494	27	.	.	.
cord-022353-q2k2krnm	495	1	The	the	DT
cord-022353-q2k2krnm	495	2	remaining	remain	VBG
cord-022353-q2k2krnm	495	3	solution	solution	NN
cord-022353-q2k2krnm	495	4	is	be	VBZ
cord-022353-q2k2krnm	495	5	then	then	RB
cord-022353-q2k2krnm	495	6	tested	test	VBN
cord-022353-q2k2krnm	495	7	for	for	IN
cord-022353-q2k2krnm	495	8	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	495	9	as	as	IN
cord-022353-q2k2krnm	495	10	described	describe	VBN
cord-022353-q2k2krnm	495	11	previously	previously	RB
cord-022353-q2k2krnm	495	12	.	.	.
cord-022353-q2k2krnm	496	1	The	the	DT
cord-022353-q2k2krnm	496	2	non	non	JJ
cord-022353-q2k2krnm	496	3	-	-	JJ
cord-022353-q2k2krnm	496	4	HDL	hdl	JJ
cord-022353-q2k2krnm	496	5	-	-	HYPH
cord-022353-q2k2krnm	496	6	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	496	7	component	component	NN
cord-022353-q2k2krnm	496	8	is	be	VBZ
cord-022353-q2k2krnm	496	9	calculated	calculate	VBN
cord-022353-q2k2krnm	496	10	by	by	IN
cord-022353-q2k2krnm	496	11	subtracting	subtract	VBG
cord-022353-q2k2krnm	496	12	HDL	hdl	NN
cord-022353-q2k2krnm	496	13	-	-	HYPH
cord-022353-q2k2krnm	496	14	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	496	15	from	from	IN
cord-022353-q2k2krnm	496	16	total	total	JJ
cord-022353-q2k2krnm	496	17	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	496	18	in	in	IN
cord-022353-q2k2krnm	496	19	the	the	DT
cord-022353-q2k2krnm	496	20	nonprecipitated	nonprecipitate	VBN
cord-022353-q2k2krnm	496	21	sample	sample	NN
cord-022353-q2k2krnm	496	22	(	(	-LRB-
cord-022353-q2k2krnm	496	23	Sehayek	Sehayek	NNP
cord-022353-q2k2krnm	496	24	et	et	NNP
cord-022353-q2k2krnm	496	25	al	al	NNP
cord-022353-q2k2krnm	496	26	.	.	NNP
cord-022353-q2k2krnm	496	27	2003	2003	CD
cord-022353-q2k2krnm	496	28	)	)	-RRB-
cord-022353-q2k2krnm	496	29	.	.	.
cord-022353-q2k2krnm	497	1	Some	some	DT
cord-022353-q2k2krnm	497	2	strains	strain	NNS
cord-022353-q2k2krnm	497	3	develop	develop	VBP
cord-022353-q2k2krnm	497	4	elevated	elevated	JJ
cord-022353-q2k2krnm	497	5	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	497	6	levels	level	NNS
cord-022353-q2k2krnm	497	7	associated	associate	VBN
cord-022353-q2k2krnm	497	8	with	with	IN
cord-022353-q2k2krnm	497	9	increases	increase	NNS
cord-022353-q2k2krnm	497	10	in	in	IN
cord-022353-q2k2krnm	497	11	non	non	JJ
cord-022353-q2k2krnm	497	12	-	-	JJ
cord-022353-q2k2krnm	497	13	HDL	hdl	JJ
cord-022353-q2k2krnm	497	14	levels	level	NNS
cord-022353-q2k2krnm	497	15	after	after	IN
cord-022353-q2k2krnm	497	16	consuming	consume	VBG
cord-022353-q2k2krnm	497	17	high	high	JJ
cord-022353-q2k2krnm	497	18	fat	fat	JJ
cord-022353-q2k2krnm	497	19	diets	diet	NNS
cord-022353-q2k2krnm	497	20	(	(	-LRB-
cord-022353-q2k2krnm	497	21	Breslow	Breslow	NNP
cord-022353-q2k2krnm	497	22	1994	1994	CD
cord-022353-q2k2krnm	497	23	)	)	-RRB-
cord-022353-q2k2krnm	497	24	.	.	.
cord-022353-q2k2krnm	498	1	c.	c.	NNP
cord-022353-q2k2krnm	498	2	MOUSE	MOUSE	NNP
cord-022353-q2k2krnm	498	3	APOPROTEINS	APOPROTEINS	NNP
cord-022353-q2k2krnm	498	4	Commercial	commercial	JJ
cord-022353-q2k2krnm	498	5	antibodies	antibody	NNS
cord-022353-q2k2krnm	498	6	against	against	IN
cord-022353-q2k2krnm	498	7	mouse	mouse	NN
cord-022353-q2k2krnm	498	8	apoprotein	apoprotein	NNP
cord-022353-q2k2krnm	498	9	A1	A1	NNP
cord-022353-q2k2krnm	498	10	and	and	CC
cord-022353-q2k2krnm	498	11	apoprotein	apoprotein	NNP
cord-022353-q2k2krnm	498	12	A2	A2	NNP
cord-022353-q2k2krnm	498	13	are	be	VBP
cord-022353-q2k2krnm	498	14	available	available	JJ
cord-022353-q2k2krnm	498	15	and	and	CC
cord-022353-q2k2krnm	498	16	ELISAs	elisa	NNS
cord-022353-q2k2krnm	498	17	have	have	VBP
cord-022353-q2k2krnm	498	18	been	be	VBN
cord-022353-q2k2krnm	498	19	described	describe	VBN
cord-022353-q2k2krnm	498	20	for	for	IN
cord-022353-q2k2krnm	498	21	the	the	DT
cord-022353-q2k2krnm	498	22	measurement	measurement	NN
cord-022353-q2k2krnm	498	23	of	of	IN
cord-022353-q2k2krnm	498	24	these	these	DT
cord-022353-q2k2krnm	498	25	apoproteins	apoprotein	NNS
cord-022353-q2k2krnm	498	26	in	in	IN
cord-022353-q2k2krnm	498	27	plasma	plasma	NN
cord-022353-q2k2krnm	498	28	and	and	CC
cord-022353-q2k2krnm	498	29	in	in	IN
cord-022353-q2k2krnm	498	30	HDL	HDL	NNP
cord-022353-q2k2krnm	498	31	fractions	fraction	NNS
cord-022353-q2k2krnm	498	32	of	of	IN
cord-022353-q2k2krnm	498	33	plasma	plasma	NN
cord-022353-q2k2krnm	498	34	(	(	-LRB-
cord-022353-q2k2krnm	498	35	Dansky	Dansky	NNP
cord-022353-q2k2krnm	498	36	et	et	NNP
cord-022353-q2k2krnm	498	37	al	al	NNP
cord-022353-q2k2krnm	498	38	.	.	.
cord-022353-q2k2krnm	498	39	1999	1999	CD
cord-022353-q2k2krnm	498	40	)	)	-RRB-
cord-022353-q2k2krnm	498	41	.	.	.
cord-022353-q2k2krnm	499	1	Plasma	plasma	NN
cord-022353-q2k2krnm	499	2	apoprotein	apoprotein	NN
cord-022353-q2k2krnm	499	3	A1	A1	NNP
cord-022353-q2k2krnm	499	4	levels	level	NNS
cord-022353-q2k2krnm	499	5	can	can	MD
cord-022353-q2k2krnm	499	6	also	also	RB
cord-022353-q2k2krnm	499	7	be	be	VB
cord-022353-q2k2krnm	499	8	measured	measure	VBN
cord-022353-q2k2krnm	499	9	by	by	IN
cord-022353-q2k2krnm	499	10	multiplex	multiplex	NN
cord-022353-q2k2krnm	499	11	analysis	analysis	NN
cord-022353-q2k2krnm	499	12	.	.	.
cord-022353-q2k2krnm	500	1	An	an	DT
cord-022353-q2k2krnm	500	2	assay	assay	NN
cord-022353-q2k2krnm	500	3	for	for	IN
cord-022353-q2k2krnm	500	4	mouse	mouse	NN
cord-022353-q2k2krnm	500	5	apoprotein	apoprotein	NNP
cord-022353-q2k2krnm	500	6	J	J	NNP
cord-022353-q2k2krnm	500	7	(	(	-LRB-
cord-022353-q2k2krnm	500	8	ApoJ	ApoJ	NNP
cord-022353-q2k2krnm	500	9	or	or	CC
cord-022353-q2k2krnm	500	10	clusterin	clusterin	NNP
cord-022353-q2k2krnm	500	11	)	)	-RRB-
cord-022353-q2k2krnm	500	12	has	have	VBZ
cord-022353-q2k2krnm	500	13	also	also	RB
cord-022353-q2k2krnm	500	14	been	be	VBN
cord-022353-q2k2krnm	500	15	described	describe	VBN
cord-022353-q2k2krnm	500	16	(	(	-LRB-
cord-022353-q2k2krnm	500	17	Navab	Navab	NNP
cord-022353-q2k2krnm	500	18	et	et	NNP
cord-022353-q2k2krnm	500	19	al	al	NNP
cord-022353-q2k2krnm	500	20	.	.	.
cord-022353-q2k2krnm	500	21	1997	1997	CD
cord-022353-q2k2krnm	500	22	)	)	-RRB-
cord-022353-q2k2krnm	500	23	.	.	.
cord-022353-q2k2krnm	501	1	ApoJ	ApoJ	NNP
cord-022353-q2k2krnm	501	2	,	,	,
cord-022353-q2k2krnm	501	3	which	which	WDT
cord-022353-q2k2krnm	501	4	is	be	VBZ
cord-022353-q2k2krnm	501	5	a	a	DT
cord-022353-q2k2krnm	501	6	ubiquitous	ubiquitous	JJ
cord-022353-q2k2krnm	501	7	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	501	8	postulated	postulate	VBN
cord-022353-q2k2krnm	501	9	to	to	TO
cord-022353-q2k2krnm	501	10	have	have	VB
cord-022353-q2k2krnm	501	11	multiple	multiple	JJ
cord-022353-q2k2krnm	501	12	functions	function	NNS
cord-022353-q2k2krnm	501	13	,	,	,
cord-022353-q2k2krnm	501	14	is	be	VBZ
cord-022353-q2k2krnm	501	15	associated	associate	VBN
cord-022353-q2k2krnm	501	16	with	with	IN
cord-022353-q2k2krnm	501	17	HDL	HDL	NNP
cord-022353-q2k2krnm	501	18	and	and	CC
cord-022353-q2k2krnm	501	19	is	be	VBZ
cord-022353-q2k2krnm	501	20	the	the	DT
cord-022353-q2k2krnm	501	21	amyloid	amyloid	NN
cord-022353-q2k2krnm	501	22	-	-	HYPH
cord-022353-q2k2krnm	501	23	associated	associate	VBN
cord-022353-q2k2krnm	501	24	protein	protein	NN
cord-022353-q2k2krnm	501	25	associated	associate	VBN
cord-022353-q2k2krnm	501	26	with	with	IN
cord-022353-q2k2krnm	501	27	amyloid	amyloid	NN
cord-022353-q2k2krnm	501	28	plaque	plaque	NN
cord-022353-q2k2krnm	501	29	formation	formation	NN
cord-022353-q2k2krnm	501	30	in	in	IN
cord-022353-q2k2krnm	501	31	Alzheimer	Alzheimer	NNP
cord-022353-q2k2krnm	501	32	's	's	POS
cord-022353-q2k2krnm	501	33	disease	disease	NN
cord-022353-q2k2krnm	501	34	in	in	IN
cord-022353-q2k2krnm	501	35	humans	human	NNS
cord-022353-q2k2krnm	501	36	.	.	.
cord-022353-q2k2krnm	502	1	d.	d.	NNP
cord-022353-q2k2krnm	502	2	OTHER	other	JJ
cord-022353-q2k2krnm	502	3	ANALYTES	analyte	NNS
cord-022353-q2k2krnm	502	4	ASSOCIATED	ASSOCIATED	NNP
cord-022353-q2k2krnm	502	5	WITH	with	IN
cord-022353-q2k2krnm	502	6	LIPID	lipid	NN
cord-022353-q2k2krnm	502	7	METABOLISM	metabolism	NN
cord-022353-q2k2krnm	502	8	AND	and	CC
cord-022353-q2k2krnm	502	9	ATHEROSCLEROSIS	atherosclerosis	NN
cord-022353-q2k2krnm	503	1	IN	in	IN
cord-022353-q2k2krnm	503	2	MICE	MICE	NNP
cord-022353-q2k2krnm	503	3	ELISA	ELISA	NNP
cord-022353-q2k2krnm	503	4	kits	kit	NNS
cord-022353-q2k2krnm	503	5	are	be	VBP
cord-022353-q2k2krnm	503	6	commercially	commercially	RB
cord-022353-q2k2krnm	503	7	available	available	JJ
cord-022353-q2k2krnm	503	8	for	for	IN
cord-022353-q2k2krnm	503	9	the	the	DT
cord-022353-q2k2krnm	503	10	quantitation	quantitation	NN
cord-022353-q2k2krnm	503	11	of	of	IN
cord-022353-q2k2krnm	503	12	many	many	JJ
cord-022353-q2k2krnm	503	13	mouse	mouse	NN
cord-022353-q2k2krnm	503	14	coagulation	coagulation	NN
cord-022353-q2k2krnm	503	15	proteins	protein	NNS
cord-022353-q2k2krnm	503	16	including	include	VBG
cord-022353-q2k2krnm	503	17	:	:	:
cord-022353-q2k2krnm	503	18	fibrinogen	fibrinogen	NN
cord-022353-q2k2krnm	503	19	,	,	,
cord-022353-q2k2krnm	503	20	factor	factor	NN
cord-022353-q2k2krnm	503	21	VII	vii	NN
cord-022353-q2k2krnm	503	22	,	,	,
cord-022353-q2k2krnm	503	23	d	d	NN
cord-022353-q2k2krnm	503	24	-	-	HYPH
cord-022353-q2k2krnm	503	25	dimer	dimer	JJ
cord-022353-q2k2krnm	503	26	,	,	,
cord-022353-q2k2krnm	503	27	tissue	tissue	NN
cord-022353-q2k2krnm	503	28	factor	factor	NN
cord-022353-q2k2krnm	503	29	,	,	,
cord-022353-q2k2krnm	503	30	and	and	CC
cord-022353-q2k2krnm	503	31	von	von	NNP
cord-022353-q2k2krnm	503	32	Willebrand	Willebrand	NNP
cord-022353-q2k2krnm	503	33	's	's	POS
cord-022353-q2k2krnm	503	34	factor	factor	NN
cord-022353-q2k2krnm	503	35	antigen	antigen	NN
cord-022353-q2k2krnm	503	36	.	.	.
cord-022353-q2k2krnm	504	1	ELISA	ELISA	NNP
cord-022353-q2k2krnm	504	2	kits	kit	NNS
cord-022353-q2k2krnm	504	3	are	be	VBP
cord-022353-q2k2krnm	504	4	also	also	RB
cord-022353-q2k2krnm	504	5	available	available	JJ
cord-022353-q2k2krnm	504	6	to	to	TO
cord-022353-q2k2krnm	504	7	quantify	quantify	VB
cord-022353-q2k2krnm	504	8	many	many	JJ
cord-022353-q2k2krnm	504	9	murine	murine	JJ
cord-022353-q2k2krnm	504	10	products	product	NNS
cord-022353-q2k2krnm	504	11	of	of	IN
cord-022353-q2k2krnm	504	12	arachidonic	arachidonic	JJ
cord-022353-q2k2krnm	504	13	acid	acid	NN
cord-022353-q2k2krnm	504	14	metabolism	metabolism	NN
cord-022353-q2k2krnm	504	15	including	include	VBG
cord-022353-q2k2krnm	504	16	HETE	HETE	NNP
cord-022353-q2k2krnm	504	17	.	.	.
cord-022353-q2k2krnm	505	1	Reagents	reagent	NNS
cord-022353-q2k2krnm	505	2	,	,	,
cord-022353-q2k2krnm	505	3	ELISA	ELISA	NNP
cord-022353-q2k2krnm	505	4	kits	kit	NNS
cord-022353-q2k2krnm	505	5	,	,	,
cord-022353-q2k2krnm	505	6	and	and	CC
cord-022353-q2k2krnm	505	7	multiplex	multiplex	NN
cord-022353-q2k2krnm	505	8	assays	assay	NNS
cord-022353-q2k2krnm	505	9	are	be	VBP
cord-022353-q2k2krnm	505	10	available	available	JJ
cord-022353-q2k2krnm	505	11	for	for	IN
cord-022353-q2k2krnm	505	12	murine	murine	JJ
cord-022353-q2k2krnm	505	13	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	505	14	cytokines	cytokine	NNS
cord-022353-q2k2krnm	505	15	and	and	CC
cord-022353-q2k2krnm	505	16	chemokines	chemokine	NNS
cord-022353-q2k2krnm	505	17	(	(	-LRB-
cord-022353-q2k2krnm	505	18	see	see	VB
cord-022353-q2k2krnm	505	19	the	the	DT
cord-022353-q2k2krnm	505	20	"	"	``
cord-022353-q2k2krnm	505	21	Cytokines	Cytokines	NNPS
cord-022353-q2k2krnm	505	22	and	and	CC
cord-022353-q2k2krnm	505	23	Chemokines	Chemokines	NNPS
cord-022353-q2k2krnm	505	24	"	"	''
cord-022353-q2k2krnm	505	25	section	section	NN
cord-022353-q2k2krnm	505	26	)	)	-RRB-
cord-022353-q2k2krnm	505	27	,	,	,
cord-022353-q2k2krnm	505	28	as	as	RB
cord-022353-q2k2krnm	505	29	well	well	RB
cord-022353-q2k2krnm	505	30	as	as	IN
cord-022353-q2k2krnm	505	31	monocyte	monocyte	NNP
cord-022353-q2k2krnm	505	32	colony	colony	NN
cord-022353-q2k2krnm	505	33	stimulating	stimulate	VBG
cord-022353-q2k2krnm	505	34	factor	factor	NN
cord-022353-q2k2krnm	505	35	.	.	.
cord-022353-q2k2krnm	506	1	Dansky	Dansky	NNP
cord-022353-q2k2krnm	506	2	et	et	NNP
cord-022353-q2k2krnm	506	3	al	al	NNP
cord-022353-q2k2krnm	506	4	.	.	.
cord-022353-q2k2krnm	507	1	(	(	-LRB-
cord-022353-q2k2krnm	507	2	1999	1999	CD
cord-022353-q2k2krnm	507	3	)	)	-RRB-
cord-022353-q2k2krnm	507	4	have	have	VBP
cord-022353-q2k2krnm	507	5	described	describe	VBN
cord-022353-q2k2krnm	507	6	assays	assay	NNS
cord-022353-q2k2krnm	507	7	for	for	IN
cord-022353-q2k2krnm	507	8	the	the	DT
cord-022353-q2k2krnm	507	9	quantitation	quantitation	NN
cord-022353-q2k2krnm	507	10	of	of	IN
cord-022353-q2k2krnm	507	11	murine	murine	JJ
cord-022353-q2k2krnm	507	12	aryl	aryl	NN
cord-022353-q2k2krnm	507	13	esterase	esterase	NN
cord-022353-q2k2krnm	507	14	and	and	CC
cord-022353-q2k2krnm	507	15	paraoxonase	paraoxonase	NN
cord-022353-q2k2krnm	507	16	.	.	.
cord-022353-q2k2krnm	508	1	Table	table	NN
cord-022353-q2k2krnm	508	2	6	6	CD
cord-022353-q2k2krnm	508	3	-7	-7	NNP
cord-022353-q2k2krnm	508	4	lists	list	VBZ
cord-022353-q2k2krnm	508	5	the	the	DT
cord-022353-q2k2krnm	508	6	mouse	mouse	NN
cord-022353-q2k2krnm	508	7	enzymes	enzyme	NNS
cord-022353-q2k2krnm	508	8	involved	involve	VBN
cord-022353-q2k2krnm	508	9	in	in	IN
cord-022353-q2k2krnm	508	10	lipid	lipid	NN
cord-022353-q2k2krnm	508	11	metabolism	metabolism	NN
cord-022353-q2k2krnm	508	12	with	with	IN
cord-022353-q2k2krnm	508	13	references	reference	NNS
cord-022353-q2k2krnm	508	14	that	that	WDT
cord-022353-q2k2krnm	508	15	describe	describe	VBP
cord-022353-q2k2krnm	508	16	their	-PRON-	PRP$
cord-022353-q2k2krnm	508	17	measurement	measurement	NN
cord-022353-q2k2krnm	508	18	.	.	.
cord-022353-q2k2krnm	509	1	The	the	DT
cord-022353-q2k2krnm	509	2	innate	innate	JJ
cord-022353-q2k2krnm	509	3	and	and	CC
cord-022353-q2k2krnm	509	4	adaptive	adaptive	JJ
cord-022353-q2k2krnm	509	5	immune	immune	JJ
cord-022353-q2k2krnm	509	6	responses	response	NNS
cord-022353-q2k2krnm	509	7	have	have	VBP
cord-022353-q2k2krnm	509	8	been	be	VBN
cord-022353-q2k2krnm	509	9	extensively	extensively	RB
cord-022353-q2k2krnm	509	10	studied	study	VBN
cord-022353-q2k2krnm	509	11	(	(	-LRB-
cord-022353-q2k2krnm	509	12	see	see	VB
cord-022353-q2k2krnm	509	13	Volume	volume	NN
cord-022353-q2k2krnm	509	14	4	4	CD
cord-022353-q2k2krnm	509	15	of	of	IN
cord-022353-q2k2krnm	509	16	this	this	DT
cord-022353-q2k2krnm	509	17	series	series	NN
cord-022353-q2k2krnm	509	18	)	)	-RRB-
cord-022353-q2k2krnm	509	19	and	and	CC
cord-022353-q2k2krnm	509	20	therefore	therefore	RB
cord-022353-q2k2krnm	509	21	we	-PRON-	PRP
cord-022353-q2k2krnm	509	22	will	will	MD
cord-022353-q2k2krnm	509	23	not	not	RB
cord-022353-q2k2krnm	509	24	attempt	attempt	VB
cord-022353-q2k2krnm	509	25	to	to	TO
cord-022353-q2k2krnm	509	26	describe	describe	VB
cord-022353-q2k2krnm	509	27	all	all	PDT
cord-022353-q2k2krnm	509	28	the	the	DT
cord-022353-q2k2krnm	509	29	features	feature	NNS
cord-022353-q2k2krnm	509	30	of	of	IN
cord-022353-q2k2krnm	509	31	mouse	mouse	NN
cord-022353-q2k2krnm	509	32	immunity	immunity	NN
cord-022353-q2k2krnm	509	33	in	in	IN
cord-022353-q2k2krnm	509	34	detail	detail	NN
cord-022353-q2k2krnm	509	35	here	here	RB
cord-022353-q2k2krnm	509	36	.	.	.
cord-022353-q2k2krnm	510	1	Readers	reader	NNS
cord-022353-q2k2krnm	510	2	are	be	VBP
cord-022353-q2k2krnm	510	3	directed	direct	VBN
cord-022353-q2k2krnm	510	4	to	to	IN
cord-022353-q2k2krnm	510	5	Volume	volume	NN
cord-022353-q2k2krnm	510	6	4	4	CD
cord-022353-q2k2krnm	510	7	,	,	,
cord-022353-q2k2krnm	510	8	Molecular	Molecular	NNP
cord-022353-q2k2krnm	510	9	and	and	CC
cord-022353-q2k2krnm	510	10	Cellular	Cellular	NNP
cord-022353-q2k2krnm	510	11	Immunology	Immunology	NNP
cord-022353-q2k2krnm	510	12	of	of	IN
cord-022353-q2k2krnm	510	13	the	the	DT
cord-022353-q2k2krnm	510	14	Mouse	Mouse	NNP
cord-022353-q2k2krnm	510	15	,	,	,
cord-022353-q2k2krnm	510	16	for	for	IN
cord-022353-q2k2krnm	510	17	a	a	DT
cord-022353-q2k2krnm	510	18	general	general	JJ
cord-022353-q2k2krnm	510	19	overview	overview	NN
cord-022353-q2k2krnm	510	20	,	,	,
cord-022353-q2k2krnm	510	21	and	and	CC
cord-022353-q2k2krnm	510	22	the	the	DT
cord-022353-q2k2krnm	510	23	15	15	CD
cord-022353-q2k2krnm	510	24	chapters	chapter	NNS
cord-022353-q2k2krnm	510	25	that	that	WDT
cord-022353-q2k2krnm	510	26	follow	follow	VBP
cord-022353-q2k2krnm	510	27	for	for	IN
cord-022353-q2k2krnm	510	28	a	a	DT
cord-022353-q2k2krnm	510	29	more	more	RBR
cord-022353-q2k2krnm	510	30	detailed	detailed	JJ
cord-022353-q2k2krnm	510	31	description	description	NN
cord-022353-q2k2krnm	510	32	.	.	.
cord-022353-q2k2krnm	511	1	This	this	DT
cord-022353-q2k2krnm	511	2	section	section	NN
cord-022353-q2k2krnm	511	3	describes	describe	VBZ
cord-022353-q2k2krnm	511	4	the	the	DT
cord-022353-q2k2krnm	511	5	growing	grow	VBG
cord-022353-q2k2krnm	511	6	number	number	NN
cord-022353-q2k2krnm	511	7	of	of	IN
cord-022353-q2k2krnm	511	8	quantifiable	quantifiable	JJ
cord-022353-q2k2krnm	511	9	soluble	soluble	JJ
cord-022353-q2k2krnm	511	10	serum	serum	NN
cord-022353-q2k2krnm	511	11	proteins	protein	NNS
cord-022353-q2k2krnm	511	12	and	and	CC
cord-022353-q2k2krnm	511	13	lipids	lipid	NNS
cord-022353-q2k2krnm	511	14	associated	associate	VBN
cord-022353-q2k2krnm	511	15	with	with	IN
cord-022353-q2k2krnm	511	16	immunity	immunity	NN
cord-022353-q2k2krnm	511	17	and	and	CC
cord-022353-q2k2krnm	511	18	inflammation	inflammation	NN
cord-022353-q2k2krnm	511	19	in	in	IN
cord-022353-q2k2krnm	511	20	the	the	DT
cord-022353-q2k2krnm	511	21	mouse	mouse	NN
cord-022353-q2k2krnm	511	22	(	(	-LRB-
cord-022353-q2k2krnm	511	23	see	see	VB
cord-022353-q2k2krnm	511	24	Table	table	NN
cord-022353-q2k2krnm	511	25	6	6	CD
cord-022353-q2k2krnm	511	26	-3	-3	NNP
cord-022353-q2k2krnm	511	27	)	)	-RRB-
cord-022353-q2k2krnm	511	28	.	.	.
cord-022353-q2k2krnm	512	1	Furthermore	furthermore	RB
cord-022353-q2k2krnm	512	2	,	,	,
cord-022353-q2k2krnm	512	3	in	in	IN
cord-022353-q2k2krnm	512	4	addition	addition	NN
cord-022353-q2k2krnm	512	5	to	to	IN
cord-022353-q2k2krnm	512	6	immunodeficiency	immunodeficiency	NN
cord-022353-q2k2krnm	512	7	,	,	,
cord-022353-q2k2krnm	512	8	autoimmunity	autoimmunity	NN
cord-022353-q2k2krnm	512	9	,	,	,
cord-022353-q2k2krnm	512	10	and	and	CC
cord-022353-q2k2krnm	512	11	allergy	allergy	NN
cord-022353-q2k2krnm	512	12	,	,	,
cord-022353-q2k2krnm	512	13	investigations	investigation	NNS
cord-022353-q2k2krnm	512	14	of	of	IN
cord-022353-q2k2krnm	512	15	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	512	16	,	,	,
cord-022353-q2k2krnm	512	17	obesity	obesity	NN
cord-022353-q2k2krnm	512	18	,	,	,
cord-022353-q2k2krnm	512	19	diabetes	diabetes	NN
cord-022353-q2k2krnm	512	20	,	,	,
cord-022353-q2k2krnm	512	21	cancer	cancer	NN
cord-022353-q2k2krnm	512	22	,	,	,
cord-022353-q2k2krnm	512	23	as	as	RB
cord-022353-q2k2krnm	512	24	well	well	RB
cord-022353-q2k2krnm	512	25	as	as	IN
cord-022353-q2k2krnm	512	26	infectious	infectious	JJ
cord-022353-q2k2krnm	512	27	diseases	disease	NNS
cord-022353-q2k2krnm	512	28	,	,	,
cord-022353-q2k2krnm	512	29	each	each	DT
cord-022353-q2k2krnm	512	30	have	have	VBP
cord-022353-q2k2krnm	512	31	immunologic	immunologic	JJ
cord-022353-q2k2krnm	512	32	and	and	CC
cord-022353-q2k2krnm	512	33	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	512	34	components	component	NNS
cord-022353-q2k2krnm	512	35	.	.	.
cord-022353-q2k2krnm	513	1	1	1	LS
cord-022353-q2k2krnm	513	2	.	.	.
cord-022353-q2k2krnm	514	1	Immunoglobulins	Immunoglobulins	NNP
cord-022353-q2k2krnm	514	2	(	(	-LRB-
cord-022353-q2k2krnm	514	3	Ig	Ig	NNP
cord-022353-q2k2krnm	514	4	)	)	-RRB-
cord-022353-q2k2krnm	515	1	As	as	IN
cord-022353-q2k2krnm	515	2	in	in	IN
cord-022353-q2k2krnm	515	3	humans	human	NNS
cord-022353-q2k2krnm	515	4	,	,	,
cord-022353-q2k2krnm	515	5	mouse	mouse	NN
cord-022353-q2k2krnm	515	6	immunoglobulins	immunoglobulin	NNS
cord-022353-q2k2krnm	515	7	(	(	-LRB-
cord-022353-q2k2krnm	515	8	Ig	Ig	NNP
cord-022353-q2k2krnm	515	9	)	)	-RRB-
cord-022353-q2k2krnm	515	10	are	be	VBP
cord-022353-q2k2krnm	515	11	molecules	molecule	NNS
cord-022353-q2k2krnm	515	12	composed	compose	VBN
cord-022353-q2k2krnm	515	13	of	of	IN
cord-022353-q2k2krnm	515	14	four	four	CD
cord-022353-q2k2krnm	515	15	polypeptide	polypeptide	NN
cord-022353-q2k2krnm	515	16	chains	chain	NNS
cord-022353-q2k2krnm	515	17	;	;	:
cord-022353-q2k2krnm	515	18	two	two	CD
cord-022353-q2k2krnm	515	19	of	of	IN
cord-022353-q2k2krnm	515	20	lower	low	JJR
cord-022353-q2k2krnm	515	21	molecular	molecular	JJ
cord-022353-q2k2krnm	515	22	weight	weight	NN
cord-022353-q2k2krnm	515	23	called	call	VBN
cord-022353-q2k2krnm	515	24	light	light	NN
cord-022353-q2k2krnm	515	25	(	(	-LRB-
cord-022353-q2k2krnm	515	26	L	l	NN
cord-022353-q2k2krnm	515	27	)	)	-RRB-
cord-022353-q2k2krnm	515	28	chains	chain	NNS
cord-022353-q2k2krnm	515	29	,	,	,
cord-022353-q2k2krnm	515	30	and	and	CC
cord-022353-q2k2krnm	515	31	two	two	CD
cord-022353-q2k2krnm	515	32	with	with	IN
cord-022353-q2k2krnm	515	33	higher	high	JJR
cord-022353-q2k2krnm	515	34	molecular	molecular	JJ
cord-022353-q2k2krnm	515	35	weight	weight	NN
cord-022353-q2k2krnm	515	36	called	call	VBN
cord-022353-q2k2krnm	515	37	heavy	heavy	JJ
cord-022353-q2k2krnm	515	38	(	(	-LRB-
cord-022353-q2k2krnm	515	39	H	h	NN
cord-022353-q2k2krnm	515	40	)	)	-RRB-
cord-022353-q2k2krnm	515	41	chains	chain	NNS
cord-022353-q2k2krnm	515	42	.	.	.
cord-022353-q2k2krnm	516	1	Disulfide	Disulfide	NNP
cord-022353-q2k2krnm	516	2	bonds	bond	NNS
cord-022353-q2k2krnm	516	3	link	link	VBP
cord-022353-q2k2krnm	516	4	one	one	CD
cord-022353-q2k2krnm	516	5	L	l	NN
cord-022353-q2k2krnm	516	6	chain	chain	NN
cord-022353-q2k2krnm	516	7	to	to	IN
cord-022353-q2k2krnm	516	8	one	one	CD
cord-022353-q2k2krnm	516	9	H	h	NN
cord-022353-q2k2krnm	516	10	chain	chain	NN
cord-022353-q2k2krnm	516	11	,	,	,
cord-022353-q2k2krnm	516	12	and	and	CC
cord-022353-q2k2krnm	516	13	the	the	DT
cord-022353-q2k2krnm	516	14	two	two	CD
cord-022353-q2k2krnm	516	15	H	h	NN
cord-022353-q2k2krnm	516	16	chains	chain	NNS
cord-022353-q2k2krnm	516	17	to	to	IN
cord-022353-q2k2krnm	516	18	each	each	DT
cord-022353-q2k2krnm	516	19	other	other	JJ
cord-022353-q2k2krnm	516	20	.	.	.
cord-022353-q2k2krnm	517	1	Immunoglobulin	immunoglobulin	NN
cord-022353-q2k2krnm	517	2	H	H	NNP
cord-022353-q2k2krnm	517	3	chains	chain	NNS
cord-022353-q2k2krnm	517	4	are	be	VBP
cord-022353-q2k2krnm	517	5	composed	compose	VBN
cord-022353-q2k2krnm	517	6	of	of	IN
cord-022353-q2k2krnm	517	7	four	four	CD
cord-022353-q2k2krnm	517	8	to	to	TO
cord-022353-q2k2krnm	517	9	five	five	CD
cord-022353-q2k2krnm	517	10	domains	domain	NNS
cord-022353-q2k2krnm	517	11	,	,	,
cord-022353-q2k2krnm	517	12	including	include	VBG
cord-022353-q2k2krnm	517	13	an	an	DT
cord-022353-q2k2krnm	517	14	N	n	CD
cord-022353-q2k2krnm	517	15	-	-	HYPH
cord-022353-q2k2krnm	517	16	terminal	terminal	JJ
cord-022353-q2k2krnm	517	17	variable	variable	JJ
cord-022353-q2k2krnm	517	18	region	region	NN
cord-022353-q2k2krnm	517	19	domain	domain	NN
cord-022353-q2k2krnm	517	20	and	and	CC
cord-022353-q2k2krnm	517	21	four	four	CD
cord-022353-q2k2krnm	517	22	constant	constant	JJ
cord-022353-q2k2krnm	517	23	-	-	HYPH
cord-022353-q2k2krnm	517	24	region	region	NN
cord-022353-q2k2krnm	517	25	domains	domain	NNS
cord-022353-q2k2krnm	517	26	.	.	.
cord-022353-q2k2krnm	518	1	In	in	IN
cord-022353-q2k2krnm	518	2	addition	addition	NN
cord-022353-q2k2krnm	518	3	,	,	,
cord-022353-q2k2krnm	518	4	structural	structural	JJ
cord-022353-q2k2krnm	518	5	differences	difference	NNS
cord-022353-q2k2krnm	518	6	in	in	IN
cord-022353-q2k2krnm	518	7	the	the	DT
cord-022353-q2k2krnm	518	8	constant	constant	JJ
cord-022353-q2k2krnm	518	9	-	-	HYPH
cord-022353-q2k2krnm	518	10	region	region	NN
cord-022353-q2k2krnm	518	11	domains	domain	NNS
cord-022353-q2k2krnm	518	12	of	of	IN
cord-022353-q2k2krnm	518	13	the	the	DT
cord-022353-q2k2krnm	518	14	heavy	heavy	JJ
cord-022353-q2k2krnm	518	15	chain	chain	NN
cord-022353-q2k2krnm	518	16	are	be	VBP
cord-022353-q2k2krnm	518	17	used	use	VBN
cord-022353-q2k2krnm	518	18	to	to	TO
cord-022353-q2k2krnm	518	19	classify	classify	VB
cord-022353-q2k2krnm	518	20	the	the	DT
cord-022353-q2k2krnm	518	21	five	five	CD
cord-022353-q2k2krnm	518	22	different	different	JJ
cord-022353-q2k2krnm	518	23	classes	class	NNS
cord-022353-q2k2krnm	518	24	of	of	IN
cord-022353-q2k2krnm	518	25	immunoglobulin	immunoglobulin	NN
cord-022353-q2k2krnm	518	26	,	,	,
cord-022353-q2k2krnm	518	27	IgM	IgM	NNP
cord-022353-q2k2krnm	518	28	,	,	,
cord-022353-q2k2krnm	518	29	IgG	IgG	NNP
cord-022353-q2k2krnm	518	30	,	,	,
cord-022353-q2k2krnm	518	31	IgA	IgA	NNP
cord-022353-q2k2krnm	518	32	,	,	,
cord-022353-q2k2krnm	518	33	IgE	IgE	NNP
cord-022353-q2k2krnm	518	34	,	,	,
cord-022353-q2k2krnm	518	35	and	and	CC
cord-022353-q2k2krnm	518	36	IgD.	IgD.	NNP
cord-022353-q2k2krnm	518	37	L	L	NNP
cord-022353-q2k2krnm	518	38	chains	chain	NNS
cord-022353-q2k2krnm	518	39	are	be	VBP
cord-022353-q2k2krnm	518	40	composed	compose	VBN
cord-022353-q2k2krnm	518	41	of	of	IN
cord-022353-q2k2krnm	518	42	only	only	RB
cord-022353-q2k2krnm	518	43	two	two	CD
cord-022353-q2k2krnm	518	44	domains	domain	NNS
cord-022353-q2k2krnm	518	45	and	and	CC
cord-022353-q2k2krnm	518	46	structural	structural	JJ
cord-022353-q2k2krnm	518	47	differences	difference	NNS
cord-022353-q2k2krnm	518	48	in	in	IN
cord-022353-q2k2krnm	518	49	these	these	DT
cord-022353-q2k2krnm	518	50	domains	domain	NNS
cord-022353-q2k2krnm	518	51	are	be	VBP
cord-022353-q2k2krnm	518	52	used	use	VBN
cord-022353-q2k2krnm	518	53	to	to	TO
cord-022353-q2k2krnm	518	54	classify	classify	VB
cord-022353-q2k2krnm	518	55	L	L	NNP
cord-022353-q2k2krnm	518	56	chains	chain	NNS
cord-022353-q2k2krnm	518	57	as	as	IN
cord-022353-q2k2krnm	518	58	either	either	CC
cord-022353-q2k2krnm	518	59	kappa	kappa	NN
cord-022353-q2k2krnm	518	60	or	or	CC
cord-022353-q2k2krnm	518	61	lambda	lambda	NN
cord-022353-q2k2krnm	518	62	type	type	NN
cord-022353-q2k2krnm	518	63	.	.	.
cord-022353-q2k2krnm	519	1	In	in	IN
cord-022353-q2k2krnm	519	2	the	the	DT
cord-022353-q2k2krnm	519	3	mouse	mouse	NN
cord-022353-q2k2krnm	519	4	,	,	,
cord-022353-q2k2krnm	519	5	95	95	CD
cord-022353-q2k2krnm	519	6	%	%	NN
cord-022353-q2k2krnm	519	7	of	of	IN
cord-022353-q2k2krnm	519	8	serum	serum	NN
cord-022353-q2k2krnm	519	9	Ig	Ig	NNP
cord-022353-q2k2krnm	519	10	has	have	VBZ
cord-022353-q2k2krnm	519	11	kappa	kappa	NNP
cord-022353-q2k2krnm	519	12	L	L	NNP
cord-022353-q2k2krnm	519	13	chains	chain	NNS
cord-022353-q2k2krnm	519	14	.	.	.
cord-022353-q2k2krnm	520	1	Any	any	DT
cord-022353-q2k2krnm	520	2	individual	individual	JJ
cord-022353-q2k2krnm	520	3	antibody	antibody	NN
cord-022353-q2k2krnm	520	4	secreting	secrete	VBG
cord-022353-q2k2krnm	520	5	B	b	NN
cord-022353-q2k2krnm	520	6	cell	cell	NN
cord-022353-q2k2krnm	520	7	(	(	-LRB-
cord-022353-q2k2krnm	520	8	or	or	CC
cord-022353-q2k2krnm	520	9	plasma	plasma	NN
cord-022353-q2k2krnm	520	10	cell	cell	NN
cord-022353-q2k2krnm	520	11	)	)	-RRB-
cord-022353-q2k2krnm	520	12	will	will	MD
cord-022353-q2k2krnm	520	13	make	make	VB
cord-022353-q2k2krnm	520	14	a	a	DT
cord-022353-q2k2krnm	520	15	single	single	JJ
cord-022353-q2k2krnm	520	16	Ig	Ig	NNP
cord-022353-q2k2krnm	520	17	molecule	molecule	NN
cord-022353-q2k2krnm	520	18	composed	compose	VBN
cord-022353-q2k2krnm	520	19	of	of	IN
cord-022353-q2k2krnm	520	20	two	two	CD
cord-022353-q2k2krnm	520	21	identical	identical	JJ
cord-022353-q2k2krnm	520	22	H	h	NN
cord-022353-q2k2krnm	520	23	chains	chain	NNS
cord-022353-q2k2krnm	520	24	and	and	CC
cord-022353-q2k2krnm	520	25	two	two	CD
cord-022353-q2k2krnm	520	26	identical	identical	JJ
cord-022353-q2k2krnm	520	27	L	l	NN
cord-022353-q2k2krnm	520	28	chains	chain	NNS
cord-022353-q2k2krnm	520	29	.	.	.
cord-022353-q2k2krnm	521	1	Mice	mouse	NNS
cord-022353-q2k2krnm	521	2	make	make	VBP
cord-022353-q2k2krnm	521	3	four	four	CD
cord-022353-q2k2krnm	521	4	subtypes	subtype	NNS
cord-022353-q2k2krnm	521	5	of	of	IN
cord-022353-q2k2krnm	521	6	IgG	IgG	NNP
cord-022353-q2k2krnm	521	7	:	:	:
cord-022353-q2k2krnm	521	8	IgG1	IgG1	NNP
cord-022353-q2k2krnm	521	9	,	,	,
cord-022353-q2k2krnm	521	10	IgG2a	IgG2a	NNP
cord-022353-q2k2krnm	521	11	,	,	,
cord-022353-q2k2krnm	521	12	IgG2b	IgG2b	NNP
cord-022353-q2k2krnm	521	13	,	,	,
cord-022353-q2k2krnm	521	14	and	and	CC
cord-022353-q2k2krnm	521	15	IgG3	igg3	NN
cord-022353-q2k2krnm	521	16	.	.	.
cord-022353-q2k2krnm	522	1	Certain	certain	JJ
cord-022353-q2k2krnm	522	2	strains	strain	NNS
cord-022353-q2k2krnm	522	3	,	,	,
cord-022353-q2k2krnm	522	4	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	522	5	,	,	,
cord-022353-q2k2krnm	522	6	C57B1/10	c57b1/10	NN
cord-022353-q2k2krnm	522	7	,	,	,
cord-022353-q2k2krnm	522	8	SJL	SJL	NNP
cord-022353-q2k2krnm	522	9	,	,	,
cord-022353-q2k2krnm	522	10	and	and	CC
cord-022353-q2k2krnm	522	11	NOD	NOD	NNP
cord-022353-q2k2krnm	522	12	,	,	,
cord-022353-q2k2krnm	522	13	do	do	VBP
cord-022353-q2k2krnm	522	14	not	not	RB
cord-022353-q2k2krnm	522	15	make	make	VB
cord-022353-q2k2krnm	522	16	IgG2a	igg2a	JJ
cord-022353-q2k2krnm	522	17	but	but	CC
cord-022353-q2k2krnm	522	18	rather	rather	RB
cord-022353-q2k2krnm	522	19	make	make	VB
cord-022353-q2k2krnm	522	20	a	a	DT
cord-022353-q2k2krnm	522	21	novel	novel	NN
cord-022353-q2k2krnm	522	22	IgG2c	igg2c	NN
cord-022353-q2k2krnm	522	23	.	.	.
cord-022353-q2k2krnm	523	1	The	the	DT
cord-022353-q2k2krnm	523	2	IgG	igg	NN
cord-022353-q2k2krnm	523	3	subtypes	subtype	NNS
cord-022353-q2k2krnm	523	4	in	in	IN
cord-022353-q2k2krnm	523	5	mice	mouse	NNS
cord-022353-q2k2krnm	523	6	are	be	VBP
cord-022353-q2k2krnm	523	7	not	not	RB
cord-022353-q2k2krnm	523	8	exact	exact	JJ
cord-022353-q2k2krnm	523	9	homologues	homologue	NNS
cord-022353-q2k2krnm	523	10	of	of	IN
cord-022353-q2k2krnm	523	11	human	human	JJ
cord-022353-q2k2krnm	523	12	subtypes	subtype	NNS
cord-022353-q2k2krnm	523	13	(	(	-LRB-
cord-022353-q2k2krnm	523	14	Mestas	Mestas	NNP
cord-022353-q2k2krnm	523	15	and	and	CC
cord-022353-q2k2krnm	523	16	Hughes	Hughes	NNP
cord-022353-q2k2krnm	523	17	2004	2004	CD
cord-022353-q2k2krnm	523	18	)	)	-RRB-
cord-022353-q2k2krnm	523	19	.	.	.
cord-022353-q2k2krnm	524	1	Prenatal	prenatal	JJ
cord-022353-q2k2krnm	524	2	(	(	-LRB-
cord-022353-q2k2krnm	524	3	transplacental	transplacental	NNP
cord-022353-q2k2krnm	524	4	)	)	-RRB-
cord-022353-q2k2krnm	524	5	transfer	transfer	NN
cord-022353-q2k2krnm	524	6	of	of	IN
cord-022353-q2k2krnm	524	7	maternal	maternal	JJ
cord-022353-q2k2krnm	524	8	Ig	Ig	NNPS
cord-022353-q2k2krnm	524	9	as	as	RB
cord-022353-q2k2krnm	524	10	well	well	RB
cord-022353-q2k2krnm	524	11	as	as	IN
cord-022353-q2k2krnm	524	12	postnatal	postnatal	JJ
cord-022353-q2k2krnm	524	13	transfer	transfer	NN
cord-022353-q2k2krnm	524	14	across	across	IN
cord-022353-q2k2krnm	524	15	the	the	DT
cord-022353-q2k2krnm	524	16	intestinal	intestinal	JJ
cord-022353-q2k2krnm	524	17	epithelium	epithelium	NN
cord-022353-q2k2krnm	524	18	is	be	VBZ
cord-022353-q2k2krnm	524	19	limited	limit	VBN
cord-022353-q2k2krnm	524	20	to	to	IN
cord-022353-q2k2krnm	524	21	the	the	DT
cord-022353-q2k2krnm	524	22	IgG2a	IgG2a	NNP
cord-022353-q2k2krnm	524	23	,	,	,
cord-022353-q2k2krnm	524	24	2b	2b	NNP
cord-022353-q2k2krnm	524	25	,	,	,
cord-022353-q2k2krnm	524	26	and	and	CC
cord-022353-q2k2krnm	524	27	3	3	CD
cord-022353-q2k2krnm	524	28	subclasses	subclass	NNS
cord-022353-q2k2krnm	524	29	of	of	IN
cord-022353-q2k2krnm	524	30	immunoglobulin	immunoglobulin	NN
cord-022353-q2k2krnm	524	31	and	and	CC
cord-022353-q2k2krnm	524	32	is	be	VBZ
cord-022353-q2k2krnm	524	33	mediated	mediate	VBN
cord-022353-q2k2krnm	524	34	by	by	IN
cord-022353-q2k2krnm	524	35	neonatal	neonatal	JJ
cord-022353-q2k2krnm	524	36	Fc	Fc	NNP
cord-022353-q2k2krnm	524	37	receptors	receptor	NNS
cord-022353-q2k2krnm	524	38	(	(	-LRB-
cord-022353-q2k2krnm	524	39	FcRn	FcRn	NNP
cord-022353-q2k2krnm	524	40	)	)	-RRB-
cord-022353-q2k2krnm	524	41	located	locate	VBN
cord-022353-q2k2krnm	524	42	in	in	IN
cord-022353-q2k2krnm	524	43	the	the	DT
cord-022353-q2k2krnm	524	44	placenta	placenta	NN
cord-022353-q2k2krnm	524	45	or	or	CC
cord-022353-q2k2krnm	524	46	on	on	IN
cord-022353-q2k2krnm	524	47	the	the	DT
cord-022353-q2k2krnm	524	48	intestinal	intestinal	JJ
cord-022353-q2k2krnm	524	49	brush	brush	NN
cord-022353-q2k2krnm	524	50	border	border	NN
cord-022353-q2k2krnm	524	51	of	of	IN
cord-022353-q2k2krnm	524	52	the	the	DT
cord-022353-q2k2krnm	524	53	proximal	proximal	JJ
cord-022353-q2k2krnm	524	54	small	small	JJ
cord-022353-q2k2krnm	524	55	intestine	intestine	NN
cord-022353-q2k2krnm	524	56	(	(	-LRB-
cord-022353-q2k2krnm	524	57	Bankert	Bankert	NNP
cord-022353-q2k2krnm	524	58	and	and	CC
cord-022353-q2k2krnm	524	59	Mazzaferro	Mazzaferro	NNP
cord-022353-q2k2krnm	524	60	1999	1999	CD
cord-022353-q2k2krnm	524	61	)	)	-RRB-
cord-022353-q2k2krnm	524	62	.	.	.
cord-022353-q2k2krnm	525	1	Mouse	Mouse	NNP
cord-022353-q2k2krnm	525	2	IgG2b	IgG2b	NNP
cord-022353-q2k2krnm	525	3	fixes	fix	VBZ
cord-022353-q2k2krnm	525	4	complement	complement	NN
cord-022353-q2k2krnm	525	5	by	by	IN
cord-022353-q2k2krnm	525	6	the	the	DT
cord-022353-q2k2krnm	525	7	classical	classical	JJ
cord-022353-q2k2krnm	525	8	pathway	pathway	NN
cord-022353-q2k2krnm	525	9	and	and	CC
cord-022353-q2k2krnm	525	10	IgG	IgG	NNP
cord-022353-q2k2krnm	525	11	1	1	CD
cord-022353-q2k2krnm	525	12	and	and	CC
cord-022353-q2k2krnm	525	13	IgG2a	igg2a	CD
cord-022353-q2k2krnm	525	14	fix	fix	VBP
cord-022353-q2k2krnm	525	15	complement	complement	NN
cord-022353-q2k2krnm	525	16	by	by	IN
cord-022353-q2k2krnm	525	17	the	the	DT
cord-022353-q2k2krnm	525	18	alternative	alternative	JJ
cord-022353-q2k2krnm	525	19	pathway	pathway	NN
cord-022353-q2k2krnm	525	20	.	.	.
cord-022353-q2k2krnm	526	1	IgE	IgE	NNP
cord-022353-q2k2krnm	526	2	and	and	CC
cord-022353-q2k2krnm	526	3	IgG1	IgG1	NNP
cord-022353-q2k2krnm	526	4	are	be	VBP
cord-022353-q2k2krnm	526	5	homocytotropic	homocytotropic	NNP
cord-022353-q2k2krnm	526	6	antibodies	antibody	NNS
cord-022353-q2k2krnm	526	7	capable	capable	JJ
cord-022353-q2k2krnm	526	8	of	of	IN
cord-022353-q2k2krnm	526	9	binding	bind	VBG
cord-022353-q2k2krnm	526	10	to	to	IN
cord-022353-q2k2krnm	526	11	receptors	receptor	NNS
cord-022353-q2k2krnm	526	12	on	on	IN
cord-022353-q2k2krnm	526	13	mast	mast	NN
cord-022353-q2k2krnm	526	14	cells	cell	NNS
cord-022353-q2k2krnm	526	15	and	and	CC
cord-022353-q2k2krnm	526	16	basophils	basophil	NNS
cord-022353-q2k2krnm	526	17	and	and	CC
cord-022353-q2k2krnm	526	18	mediate	mediate	VB
cord-022353-q2k2krnm	526	19	immediate	immediate	JJ
cord-022353-q2k2krnm	526	20	hypersensitivity	hypersensitivity	NN
cord-022353-q2k2krnm	526	21	reactions	reaction	NNS
cord-022353-q2k2krnm	526	22	.	.	.
cord-022353-q2k2krnm	527	1	Although	although	IN
cord-022353-q2k2krnm	527	2	IgG	IgG	NNP
cord-022353-q2k2krnm	527	3	and	and	CC
cord-022353-q2k2krnm	527	4	IgE	IgE	NNP
cord-022353-q2k2krnm	527	5	circulate	circulate	VBP
cord-022353-q2k2krnm	527	6	in	in	IN
cord-022353-q2k2krnm	527	7	the	the	DT
cord-022353-q2k2krnm	527	8	mouse	mouse	NN
cord-022353-q2k2krnm	527	9	as	as	IN
cord-022353-q2k2krnm	527	10	monomers	monomer	NNS
cord-022353-q2k2krnm	527	11	,	,	,
cord-022353-q2k2krnm	527	12	IgM	IgM	NNP
cord-022353-q2k2krnm	527	13	circulates	circulate	VBZ
cord-022353-q2k2krnm	527	14	as	as	IN
cord-022353-q2k2krnm	527	15	a	a	DT
cord-022353-q2k2krnm	527	16	pentamer	pentamer	NNP
cord-022353-q2k2krnm	527	17	and	and	CC
cord-022353-q2k2krnm	527	18	IgA	IgA	NNP
cord-022353-q2k2krnm	527	19	circulates	circulate	VBZ
cord-022353-q2k2krnm	527	20	as	as	IN
cord-022353-q2k2krnm	527	21	a	a	DT
cord-022353-q2k2krnm	527	22	polymeric	polymeric	JJ
cord-022353-q2k2krnm	527	23	molecule	molecule	NN
cord-022353-q2k2krnm	527	24	.	.	.
cord-022353-q2k2krnm	528	1	Normally	normally	RB
cord-022353-q2k2krnm	528	2	very	very	RB
cord-022353-q2k2krnm	528	3	little	little	JJ
cord-022353-q2k2krnm	528	4	IgD	igd	NN
cord-022353-q2k2krnm	528	5	can	can	MD
cord-022353-q2k2krnm	528	6	be	be	VB
cord-022353-q2k2krnm	528	7	detected	detect	VBN
cord-022353-q2k2krnm	528	8	in	in	IN
cord-022353-q2k2krnm	528	9	serum	serum	NN
cord-022353-q2k2krnm	528	10	.	.	.
cord-022353-q2k2krnm	529	1	Serum	serum	NN
cord-022353-q2k2krnm	529	2	levels	level	NNS
cord-022353-q2k2krnm	529	3	of	of	IN
cord-022353-q2k2krnm	529	4	IgM	IgM	NNP
cord-022353-q2k2krnm	529	5	,	,	,
cord-022353-q2k2krnm	529	6	IgA	IgA	NNP
cord-022353-q2k2krnm	529	7	,	,	,
cord-022353-q2k2krnm	529	8	IgG	IgG	NNP
cord-022353-q2k2krnm	529	9	,	,	,
cord-022353-q2k2krnm	529	10	and	and	CC
cord-022353-q2k2krnm	529	11	IgE	IgE	NNP
cord-022353-q2k2krnm	529	12	are	be	VBP
cord-022353-q2k2krnm	529	13	influenced	influence	VBN
cord-022353-q2k2krnm	529	14	by	by	IN
cord-022353-q2k2krnm	529	15	the	the	DT
cord-022353-q2k2krnm	529	16	rate	rate	NN
cord-022353-q2k2krnm	529	17	of	of	IN
cord-022353-q2k2krnm	529	18	synthesis	synthesis	NN
cord-022353-q2k2krnm	529	19	and	and	CC
cord-022353-q2k2krnm	529	20	rate	rate	NN
cord-022353-q2k2krnm	529	21	of	of	IN
cord-022353-q2k2krnm	529	22	catabolism	catabolism	NN
cord-022353-q2k2krnm	529	23	.	.	.
cord-022353-q2k2krnm	530	1	Like	like	IN
cord-022353-q2k2krnm	530	2	humans	human	NNS
cord-022353-q2k2krnm	530	3	,	,	,
cord-022353-q2k2krnm	530	4	the	the	DT
cord-022353-q2k2krnm	530	5	rate	rate	NN
cord-022353-q2k2krnm	530	6	of	of	IN
cord-022353-q2k2krnm	530	7	IgG	igg	NN
cord-022353-q2k2krnm	530	8	catabolism	catabolism	NN
cord-022353-q2k2krnm	530	9	in	in	IN
cord-022353-q2k2krnm	530	10	mice	mice	NN
cord-022353-q2k2krnm	530	11	is	be	VBZ
cord-022353-q2k2krnm	530	12	directly	directly	RB
cord-022353-q2k2krnm	530	13	proportional	proportional	JJ
cord-022353-q2k2krnm	530	14	to	to	IN
cord-022353-q2k2krnm	530	15	the	the	DT
cord-022353-q2k2krnm	530	16	serum	serum	NN
cord-022353-q2k2krnm	530	17	concentration	concentration	NN
cord-022353-q2k2krnm	530	18	of	of	IN
cord-022353-q2k2krnm	530	19	the	the	DT
cord-022353-q2k2krnm	530	20	subclass	subclass	NN
cord-022353-q2k2krnm	530	21	.	.	.
cord-022353-q2k2krnm	531	1	The	the	DT
cord-022353-q2k2krnm	531	2	average	average	JJ
cord-022353-q2k2krnm	531	3	half	half	JJ
cord-022353-q2k2krnm	531	4	-	-	HYPH
cord-022353-q2k2krnm	531	5	life	life	NN
cord-022353-q2k2krnm	531	6	of	of	IN
cord-022353-q2k2krnm	531	7	murine	murine	JJ
cord-022353-q2k2krnm	531	8	IgG	igg	NN
cord-022353-q2k2krnm	531	9	is	be	VBZ
cord-022353-q2k2krnm	531	10	4.5	4.5	CD
cord-022353-q2k2krnm	531	11	days	day	NNS
cord-022353-q2k2krnm	531	12	.	.	.
cord-022353-q2k2krnm	532	1	The	the	DT
cord-022353-q2k2krnm	532	2	catabolic	catabolic	JJ
cord-022353-q2k2krnm	532	3	rate	rate	NN
cord-022353-q2k2krnm	532	4	of	of	IN
cord-022353-q2k2krnm	532	5	IgA	IgA	NNP
cord-022353-q2k2krnm	532	6	is	be	VBZ
cord-022353-q2k2krnm	532	7	independent	independent	JJ
cord-022353-q2k2krnm	532	8	of	of	IN
cord-022353-q2k2krnm	532	9	serum	serum	NN
cord-022353-q2k2krnm	532	10	concentration	concentration	NN
cord-022353-q2k2krnm	532	11	.	.	.
cord-022353-q2k2krnm	533	1	Mice	mouse	NNS
cord-022353-q2k2krnm	533	2	synthesize	synthesize	VBP
cord-022353-q2k2krnm	533	3	from	from	IN
cord-022353-q2k2krnm	533	4	50	50	CD
cord-022353-q2k2krnm	533	5	-	-	SYM
cord-022353-q2k2krnm	533	6	130	130	CD
cord-022353-q2k2krnm	533	7	mg	mg	NNP
cord-022353-q2k2krnm	533	8	/	/	SYM
cord-022353-q2k2krnm	533	9	kg	kg	NNP
cord-022353-q2k2krnm	533	10	/	/	SYM
cord-022353-q2k2krnm	533	11	day	day	NN
cord-022353-q2k2krnm	533	12	of	of	IN
cord-022353-q2k2krnm	533	13	total	total	JJ
cord-022353-q2k2krnm	533	14	Ig	Ig	NNP
cord-022353-q2k2krnm	533	15	,	,	,
cord-022353-q2k2krnm	533	16	although	although	IN
cord-022353-q2k2krnm	533	17	this	this	DT
cord-022353-q2k2krnm	533	18	is	be	VBZ
cord-022353-q2k2krnm	533	19	dependent	dependent	JJ
cord-022353-q2k2krnm	533	20	on	on	IN
cord-022353-q2k2krnm	533	21	strain	strain	NN
cord-022353-q2k2krnm	533	22	and	and	CC
cord-022353-q2k2krnm	533	23	level	level	NN
cord-022353-q2k2krnm	533	24	of	of	IN
cord-022353-q2k2krnm	533	25	antigenic	antigenic	JJ
cord-022353-q2k2krnm	533	26	stimulation	stimulation	NN
cord-022353-q2k2krnm	533	27	.	.	.
cord-022353-q2k2krnm	534	1	Certain	certain	JJ
cord-022353-q2k2krnm	534	2	strains	strain	NNS
cord-022353-q2k2krnm	534	3	have	have	VBP
cord-022353-q2k2krnm	534	4	a	a	DT
cord-022353-q2k2krnm	534	5	propensity	propensity	NN
cord-022353-q2k2krnm	534	6	to	to	TO
cord-022353-q2k2krnm	534	7	develop	develop	VB
cord-022353-q2k2krnm	534	8	specific	specific	JJ
cord-022353-q2k2krnm	534	9	T	t	NN
cord-022353-q2k2krnm	534	10	-	-	HYPH
cord-022353-q2k2krnm	534	11	helper	helper	NN
cord-022353-q2k2krnm	534	12	(	(	-LRB-
cord-022353-q2k2krnm	534	13	TH	TH	NNP
cord-022353-q2k2krnm	534	14	,	,	,
cord-022353-q2k2krnm	534	15	CD4	CD4	NNP
cord-022353-q2k2krnm	534	16	+	+	CC
cord-022353-q2k2krnm	534	17	)	)	-RRB-
cord-022353-q2k2krnm	534	18	cell	cell	NN
cord-022353-q2k2krnm	534	19	subclasses	subclass	NNS
cord-022353-q2k2krnm	534	20	in	in	IN
cord-022353-q2k2krnm	534	21	response	response	NN
cord-022353-q2k2krnm	534	22	to	to	IN
cord-022353-q2k2krnm	534	23	antigenic	antigenic	JJ
cord-022353-q2k2krnm	534	24	stimulation	stimulation	NN
cord-022353-q2k2krnm	534	25	,	,	,
cord-022353-q2k2krnm	534	26	and	and	CC
cord-022353-q2k2krnm	534	27	these	these	DT
cord-022353-q2k2krnm	534	28	strains	strain	NNS
cord-022353-q2k2krnm	534	29	are	be	VBP
cord-022353-q2k2krnm	534	30	referred	refer	VBN
cord-022353-q2k2krnm	534	31	to	to	IN
cord-022353-q2k2krnm	534	32	as	as	IN
cord-022353-q2k2krnm	534	33	having	have	VBG
cord-022353-q2k2krnm	534	34	principally	principally	RB
cord-022353-q2k2krnm	534	35	a	a	DT
cord-022353-q2k2krnm	534	36	TH1	TH1	NNP
cord-022353-q2k2krnm	534	37	or	or	CC
cord-022353-q2k2krnm	534	38	TH2	TH2	NNP
cord-022353-q2k2krnm	534	39	-	-	HYPH
cord-022353-q2k2krnm	534	40	1ike	1ike	CD
cord-022353-q2k2krnm	534	41	phenotype	phenotype	NN
cord-022353-q2k2krnm	534	42	.	.	.
cord-022353-q2k2krnm	535	1	Typically	typically	RB
cord-022353-q2k2krnm	535	2	CD4	CD4	NNP
cord-022353-q2k2krnm	535	3	+	+	CC
cord-022353-q2k2krnm	535	4	lymphocytes	lymphocyte	NNS
cord-022353-q2k2krnm	535	5	modulate	modulate	VBP
cord-022353-q2k2krnm	535	6	immune	immune	JJ
cord-022353-q2k2krnm	535	7	responses	response	NNS
cord-022353-q2k2krnm	535	8	by	by	IN
cord-022353-q2k2krnm	535	9	the	the	DT
cord-022353-q2k2krnm	535	10	cytokines	cytokine	NNS
cord-022353-q2k2krnm	535	11	they	-PRON-	PRP
cord-022353-q2k2krnm	535	12	secrete	secrete	VBP
cord-022353-q2k2krnm	535	13	.	.	.
cord-022353-q2k2krnm	536	1	Those	those	DT
cord-022353-q2k2krnm	536	2	secreting	secrete	VBG
cord-022353-q2k2krnm	536	3	IL-1	IL-1	NNP
cord-022353-q2k2krnm	536	4	,	,	,
cord-022353-q2k2krnm	536	5	IFN	IFN	NNP
cord-022353-q2k2krnm	536	6	-	-	HYPH
cord-022353-q2k2krnm	536	7	y	y	NNP
cord-022353-q2k2krnm	536	8	,	,	,
cord-022353-q2k2krnm	536	9	and	and	CC
cord-022353-q2k2krnm	536	10	lymphotoxin	lymphotoxin	NNP
cord-022353-q2k2krnm	536	11	are	be	VBP
cord-022353-q2k2krnm	536	12	generally	generally	RB
cord-022353-q2k2krnm	536	13	referred	refer	VBN
cord-022353-q2k2krnm	536	14	to	to	IN
cord-022353-q2k2krnm	536	15	as	as	IN
cord-022353-q2k2krnm	536	16	TH1	TH1	NNP
cord-022353-q2k2krnm	536	17	(	(	-LRB-
cord-022353-q2k2krnm	536	18	and	and	CC
cord-022353-q2k2krnm	536	19	are	be	VBP
cord-022353-q2k2krnm	536	20	favored	favor	VBN
cord-022353-q2k2krnm	536	21	responses	response	NNS
cord-022353-q2k2krnm	536	22	for	for	IN
cord-022353-q2k2krnm	536	23	immunity	immunity	NN
cord-022353-q2k2krnm	536	24	against	against	IN
cord-022353-q2k2krnm	536	25	viruses	virus	NNS
cord-022353-q2k2krnm	536	26	and	and	CC
cord-022353-q2k2krnm	536	27	intracellular	intracellular	JJ
cord-022353-q2k2krnm	536	28	pathogens	pathogen	NNS
cord-022353-q2k2krnm	536	29	)	)	-RRB-
cord-022353-q2k2krnm	536	30	and	and	CC
cord-022353-q2k2krnm	536	31	those	those	DT
cord-022353-q2k2krnm	536	32	secreting	secrete	VBG
cord-022353-q2k2krnm	536	33	IL-4	IL-4	NNP
cord-022353-q2k2krnm	536	34	,	,	,
cord-022353-q2k2krnm	536	35	IL-5	IL-5	NNP
cord-022353-q2k2krnm	536	36	,	,	,
cord-022353-q2k2krnm	536	37	IL-10	IL-10	NNP
cord-022353-q2k2krnm	536	38	,	,	,
cord-022353-q2k2krnm	536	39	and	and	CC
cord-022353-q2k2krnm	536	40	IL-13	IL-13	NNP
cord-022353-q2k2krnm	536	41	are	be	VBP
cord-022353-q2k2krnm	536	42	referred	refer	VBN
cord-022353-q2k2krnm	536	43	to	to	IN
cord-022353-q2k2krnm	536	44	as	as	IN
cord-022353-q2k2krnm	536	45	TH2	TH2	NNP
cord-022353-q2k2krnm	536	46	(	(	-LRB-
cord-022353-q2k2krnm	536	47	and	and	CC
cord-022353-q2k2krnm	536	48	enhance	enhance	VB
cord-022353-q2k2krnm	536	49	humoral	humoral	JJ
cord-022353-q2k2krnm	536	50	immunity	immunity	NN
cord-022353-q2k2krnm	536	51	while	while	IN
cord-022353-q2k2krnm	536	52	suppressing	suppress	VBG
cord-022353-q2k2krnm	536	53	cell	cell	NN
cord-022353-q2k2krnm	536	54	mediated	mediate	VBN
cord-022353-q2k2krnm	536	55	immunity	immunity	NN
cord-022353-q2k2krnm	536	56	)	)	-RRB-
cord-022353-q2k2krnm	536	57	.	.	.
cord-022353-q2k2krnm	537	1	When	when	WRB
cord-022353-q2k2krnm	537	2	confronted	confront	VBN
cord-022353-q2k2krnm	537	3	with	with	IN
cord-022353-q2k2krnm	537	4	the	the	DT
cord-022353-q2k2krnm	537	5	same	same	JJ
cord-022353-q2k2krnm	537	6	antigen	antigen	NN
cord-022353-q2k2krnm	537	7	,	,	,
cord-022353-q2k2krnm	537	8	BALB	BALB	NNP
cord-022353-q2k2krnm	537	9	/	/	SYM
cord-022353-q2k2krnm	537	10	c	c	NN
cord-022353-q2k2krnm	537	11	mice	mouse	NNS
cord-022353-q2k2krnm	537	12	exhibit	exhibit	VBP
cord-022353-q2k2krnm	537	13	a	a	DT
cord-022353-q2k2krnm	537	14	TH2-dominant	th2-dominant	JJ
cord-022353-q2k2krnm	537	15	response	response	NN
cord-022353-q2k2krnm	537	16	,	,	,
cord-022353-q2k2krnm	537	17	and	and	CC
cord-022353-q2k2krnm	537	18	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	537	19	mice	mouse	NNS
cord-022353-q2k2krnm	537	20	exhibit	exhibit	VBP
cord-022353-q2k2krnm	537	21	a	a	DT
cord-022353-q2k2krnm	537	22	THl	THl	NNP
cord-022353-q2k2krnm	537	23	-	-	HYPH
cord-022353-q2k2krnm	537	24	dominant	dominant	JJ
cord-022353-q2k2krnm	537	25	response	response	NN
cord-022353-q2k2krnm	537	26	.	.	.
cord-022353-q2k2krnm	538	1	IL-4	IL-4	NNP
cord-022353-q2k2krnm	538	2	participates	participate	VBZ
cord-022353-q2k2krnm	538	3	in	in	IN
cord-022353-q2k2krnm	538	4	immunoglobulin	immunoglobulin	NN
cord-022353-q2k2krnm	538	5	(	(	-LRB-
cord-022353-q2k2krnm	538	6	antibody	antibody	NN
cord-022353-q2k2krnm	538	7	)	)	-RRB-
cord-022353-q2k2krnm	538	8	class	class	NN
cord-022353-q2k2krnm	538	9	switching	switching	NN
cord-022353-q2k2krnm	538	10	(	(	-LRB-
cord-022353-q2k2krnm	538	11	see	see	VB
cord-022353-q2k2krnm	538	12	Volume	volume	NN
cord-022353-q2k2krnm	538	13	4	4	CD
cord-022353-q2k2krnm	538	14	,	,	,
cord-022353-q2k2krnm	538	15	chapter	chapter	NN
cord-022353-q2k2krnm	538	16	5	5	CD
cord-022353-q2k2krnm	538	17	)	)	-RRB-
cord-022353-q2k2krnm	538	18	.	.	.
cord-022353-q2k2krnm	539	1	Consequently	consequently	RB
cord-022353-q2k2krnm	539	2	,	,	,
cord-022353-q2k2krnm	539	3	TH2	TH2	NNP
cord-022353-q2k2krnm	539	4	strains	strain	NNS
cord-022353-q2k2krnm	539	5	are	be	VBP
cord-022353-q2k2krnm	539	6	the	the	DT
cord-022353-q2k2krnm	539	7	models	model	NNS
cord-022353-q2k2krnm	539	8	of	of	IN
cord-022353-q2k2krnm	539	9	choice	choice	NN
cord-022353-q2k2krnm	539	10	for	for	IN
cord-022353-q2k2krnm	539	11	investigations	investigation	NNS
cord-022353-q2k2krnm	539	12	of	of	IN
cord-022353-q2k2krnm	539	13	allergic	allergic	JJ
cord-022353-q2k2krnm	539	14	inflammation	inflammation	NN
cord-022353-q2k2krnm	539	15	because	because	IN
cord-022353-q2k2krnm	539	16	they	-PRON-	PRP
cord-022353-q2k2krnm	539	17	produce	produce	VBP
cord-022353-q2k2krnm	539	18	higher	high	JJR
cord-022353-q2k2krnm	539	19	concentrations	concentration	NNS
cord-022353-q2k2krnm	539	20	of	of	IN
cord-022353-q2k2krnm	539	21	IL-4	IL-4	NNP
cord-022353-q2k2krnm	539	22	induced	induce	VBN
cord-022353-q2k2krnm	539	23	immunoglobulin	immunoglobulin	NN
cord-022353-q2k2krnm	539	24	classes	class	NNS
cord-022353-q2k2krnm	539	25	(	(	-LRB-
cord-022353-q2k2krnm	539	26	IgE	IgE	NNP
cord-022353-q2k2krnm	539	27	and	and	CC
cord-022353-q2k2krnm	539	28	IgG1	IgG1	NNP
cord-022353-q2k2krnm	539	29	)	)	-RRB-
cord-022353-q2k2krnm	539	30	.	.	.
cord-022353-q2k2krnm	540	1	The	the	DT
cord-022353-q2k2krnm	540	2	CBA	CBA	NNP
cord-022353-q2k2krnm	540	3	/	/	SYM
cord-022353-q2k2krnm	540	4	N	n	CD
cord-022353-q2k2krnm	540	5	strain	strain	NN
cord-022353-q2k2krnm	540	6	is	be	VBZ
cord-022353-q2k2krnm	540	7	deficient	deficient	JJ
cord-022353-q2k2krnm	540	8	in	in	IN
cord-022353-q2k2krnm	540	9	its	-PRON-	PRP$
cord-022353-q2k2krnm	540	10	ability	ability	NN
cord-022353-q2k2krnm	540	11	to	to	TO
cord-022353-q2k2krnm	540	12	produce	produce	VB
cord-022353-q2k2krnm	540	13	IgM	IgM	NNP
cord-022353-q2k2krnm	540	14	and	and	CC
cord-022353-q2k2krnm	540	15	IgG3	IgG3	NNP
cord-022353-q2k2krnm	540	16	.	.	.
cord-022353-q2k2krnm	541	1	Immunoglobulin	immunoglobulin	NN
cord-022353-q2k2krnm	541	2	levels	level	NNS
cord-022353-q2k2krnm	541	3	are	be	VBP
cord-022353-q2k2krnm	541	4	also	also	RB
cord-022353-q2k2krnm	541	5	greatly	greatly	RB
cord-022353-q2k2krnm	541	6	reduced	reduce	VBN
cord-022353-q2k2krnm	541	7	in	in	IN
cord-022353-q2k2krnm	541	8	germ	germ	NN
cord-022353-q2k2krnm	541	9	-	-	HYPH
cord-022353-q2k2krnm	541	10	free	free	JJ
cord-022353-q2k2krnm	541	11	mice	mouse	NNS
cord-022353-q2k2krnm	541	12	,	,	,
cord-022353-q2k2krnm	541	13	offspring	offspring	NN
cord-022353-q2k2krnm	541	14	of	of	IN
cord-022353-q2k2krnm	541	15	mice	mouse	NNS
cord-022353-q2k2krnm	541	16	on	on	IN
cord-022353-q2k2krnm	541	17	zinc	zinc	NN
cord-022353-q2k2krnm	541	18	-	-	HYPH
cord-022353-q2k2krnm	541	19	deficient	deficient	JJ
cord-022353-q2k2krnm	541	20	diets	diet	NNS
cord-022353-q2k2krnm	541	21	,	,	,
cord-022353-q2k2krnm	541	22	and	and	CC
cord-022353-q2k2krnm	541	23	mice	mouse	NNS
cord-022353-q2k2krnm	541	24	on	on	IN
cord-022353-q2k2krnm	541	25	protein	protein	NN
cord-022353-q2k2krnm	541	26	-	-	HYPH
cord-022353-q2k2krnm	541	27	deficient	deficient	JJ
cord-022353-q2k2krnm	541	28	diets	diet	NNS
cord-022353-q2k2krnm	541	29	(	(	-LRB-
cord-022353-q2k2krnm	541	30	Quimby	Quimby	NNP
cord-022353-q2k2krnm	541	31	1999b	1999b	CD
cord-022353-q2k2krnm	541	32	)	)	-RRB-
cord-022353-q2k2krnm	541	33	.	.	.
cord-022353-q2k2krnm	542	1	Quantifying	quantify	VBG
cord-022353-q2k2krnm	542	2	the	the	DT
cord-022353-q2k2krnm	542	3	various	various	JJ
cord-022353-q2k2krnm	542	4	classes	class	NNS
cord-022353-q2k2krnm	542	5	and	and	CC
cord-022353-q2k2krnm	542	6	subclasses	subclass	NNS
cord-022353-q2k2krnm	542	7	of	of	IN
cord-022353-q2k2krnm	542	8	murine	murine	JJ
cord-022353-q2k2krnm	542	9	Ig	Ig	NNP
cord-022353-q2k2krnm	542	10	can	can	MD
cord-022353-q2k2krnm	542	11	be	be	VB
cord-022353-q2k2krnm	542	12	done	do	VBN
cord-022353-q2k2krnm	542	13	using	use	VBG
cord-022353-q2k2krnm	542	14	various	various	JJ
cord-022353-q2k2krnm	542	15	immunoassays	immunoassay	NNS
cord-022353-q2k2krnm	542	16	including	include	VBG
cord-022353-q2k2krnm	542	17	:	:	:
cord-022353-q2k2krnm	542	18	radial	radial	JJ
cord-022353-q2k2krnm	542	19	immunodiffusion	immunodiffusion	NN
cord-022353-q2k2krnm	542	20	,	,	,
cord-022353-q2k2krnm	542	21	RIA	RIA	NNP
cord-022353-q2k2krnm	542	22	,	,	,
cord-022353-q2k2krnm	542	23	or	or	CC
cord-022353-q2k2krnm	542	24	enzyme	enzyme	NN
cord-022353-q2k2krnm	542	25	immunoassay	immunoassay	NN
cord-022353-q2k2krnm	542	26	.	.	.
cord-022353-q2k2krnm	543	1	Both	both	DT
cord-022353-q2k2krnm	543	2	RIA	RIA	NNP
cord-022353-q2k2krnm	543	3	and	and	CC
cord-022353-q2k2krnm	543	4	enzyme	enzyme	NN
cord-022353-q2k2krnm	543	5	immunoassay	immunoassay	NN
cord-022353-q2k2krnm	543	6	have	have	VBP
cord-022353-q2k2krnm	543	7	the	the	DT
cord-022353-q2k2krnm	543	8	higher	high	JJR
cord-022353-q2k2krnm	543	9	degrees	degree	NNS
cord-022353-q2k2krnm	543	10	of	of	IN
cord-022353-q2k2krnm	543	11	sensitivity	sensitivity	NN
cord-022353-q2k2krnm	543	12	that	that	WDT
cord-022353-q2k2krnm	543	13	are	be	VBP
cord-022353-q2k2krnm	543	14	needed	need	VBN
cord-022353-q2k2krnm	543	15	to	to	TO
cord-022353-q2k2krnm	543	16	accurately	accurately	RB
cord-022353-q2k2krnm	543	17	quantitate	quantitate	VB
cord-022353-q2k2krnm	543	18	levels	level	NNS
cord-022353-q2k2krnm	543	19	of	of	IN
cord-022353-q2k2krnm	543	20	IgE	IgE	NNP
cord-022353-q2k2krnm	543	21	and	and	CC
cord-022353-q2k2krnm	543	22	IgD	IgD	NNP
cord-022353-q2k2krnm	543	23	in	in	IN
cord-022353-q2k2krnm	543	24	murine	murine	JJ
cord-022353-q2k2krnm	543	25	serum	serum	NN
cord-022353-q2k2krnm	543	26	.	.	.
cord-022353-q2k2krnm	544	1	Enzyme	enzyme	NN
cord-022353-q2k2krnm	544	2	immunoassay	immunoassay	NN
cord-022353-q2k2krnm	544	3	has	have	VBZ
cord-022353-q2k2krnm	544	4	become	become	VBN
cord-022353-q2k2krnm	544	5	the	the	DT
cord-022353-q2k2krnm	544	6	favored	favored	JJ
cord-022353-q2k2krnm	544	7	assay	assay	NN
cord-022353-q2k2krnm	544	8	to	to	TO
cord-022353-q2k2krnm	544	9	avoid	avoid	VB
cord-022353-q2k2krnm	544	10	isotope	isotope	NN
cord-022353-q2k2krnm	544	11	handling	handling	NN
cord-022353-q2k2krnm	544	12	and	and	CC
cord-022353-q2k2krnm	544	13	disposal	disposal	NN
cord-022353-q2k2krnm	544	14	.	.	.
cord-022353-q2k2krnm	545	1	The	the	DT
cord-022353-q2k2krnm	545	2	reported	report	VBN
cord-022353-q2k2krnm	545	3	concentrations	concentration	NNS
cord-022353-q2k2krnm	545	4	of	of	IN
cord-022353-q2k2krnm	545	5	normal	normal	JJ
cord-022353-q2k2krnm	545	6	BALB	BALB	NNP
cord-022353-q2k2krnm	545	7	/	/	SYM
cord-022353-q2k2krnm	545	8	c	c	NN
cord-022353-q2k2krnm	545	9	mice	mouse	NNS
cord-022353-q2k2krnm	545	10	are	be	VBP
cord-022353-q2k2krnm	545	11	:	:	:
cord-022353-q2k2krnm	545	12	IgG1	IgG1	NNP
cord-022353-q2k2krnm	545	13	(	(	-LRB-
cord-022353-q2k2krnm	545	14	6.5	6.5	CD
cord-022353-q2k2krnm	545	15	mg	mg	NNP
cord-022353-q2k2krnm	545	16	/	/	SYM
cord-022353-q2k2krnm	545	17	ml	ml	NNP
cord-022353-q2k2krnm	545	18	)	)	-RRB-
cord-022353-q2k2krnm	545	19	,	,	.
cord-022353-q2k2krnm	546	1	IgG2a	igg2a	JJ
cord-022353-q2k2krnm	546	2	(	(	-LRB-
cord-022353-q2k2krnm	546	3	4.2	4.2	CD
cord-022353-q2k2krnm	546	4	mg	mg	NNP
cord-022353-q2k2krnm	546	5	/	/	SYM
cord-022353-q2k2krnm	546	6	ml	ml	NNP
cord-022353-q2k2krnm	546	7	)	)	-RRB-
cord-022353-q2k2krnm	546	8	,	,	,
cord-022353-q2k2krnm	546	9	IgG2b	IgG2b	NNP
cord-022353-q2k2krnm	546	10	(	(	-LRB-
cord-022353-q2k2krnm	546	11	1.2	1.2	CD
cord-022353-q2k2krnm	546	12	mg	mg	NNP
cord-022353-q2k2krnm	546	13	/	/	SYM
cord-022353-q2k2krnm	546	14	ml	ml	NNP
cord-022353-q2k2krnm	546	15	)	)	-RRB-
cord-022353-q2k2krnm	546	16	,	,	.
cord-022353-q2k2krnm	547	1	IgG3	IgG3	NNP
cord-022353-q2k2krnm	547	2	(	(	-LRB-
cord-022353-q2k2krnm	547	3	0.1	0.1	CD
cord-022353-q2k2krnm	547	4	-	-	SYM
cord-022353-q2k2krnm	547	5	0.2	0.2	CD
cord-022353-q2k2krnm	547	6	mg	mg	NNP
cord-022353-q2k2krnm	547	7	/	/	SYM
cord-022353-q2k2krnm	547	8	ml	ml	NNP
cord-022353-q2k2krnm	547	9	)	)	-RRB-
cord-022353-q2k2krnm	547	10	,	,	,
cord-022353-q2k2krnm	547	11	IgA	IgA	NNP
cord-022353-q2k2krnm	547	12	(	(	-LRB-
cord-022353-q2k2krnm	547	13	0.7	0.7	CD
cord-022353-q2k2krnm	547	14	mg	mg	NNP
cord-022353-q2k2krnm	547	15	/	/	SYM
cord-022353-q2k2krnm	547	16	ml	ml	NNP
cord-022353-q2k2krnm	547	17	)	)	-RRB-
cord-022353-q2k2krnm	547	18	,	,	,
cord-022353-q2k2krnm	547	19	IgM	IgM	NNP
cord-022353-q2k2krnm	547	20	(	(	-LRB-
cord-022353-q2k2krnm	547	21	1.0	1.0	CD
cord-022353-q2k2krnm	547	22	mg	mg	NNP
cord-022353-q2k2krnm	547	23	/	/	SYM
cord-022353-q2k2krnm	547	24	ml	ml	NNP
cord-022353-q2k2krnm	547	25	)	)	-RRB-
cord-022353-q2k2krnm	547	26	,	,	,
cord-022353-q2k2krnm	547	27	and	and	CC
cord-022353-q2k2krnm	547	28	IgE	IgE	NNP
cord-022353-q2k2krnm	547	29	and	and	CC
cord-022353-q2k2krnm	547	30	IgD	IgD	NNP
cord-022353-q2k2krnm	547	31	are	be	VBP
cord-022353-q2k2krnm	547	32	both	both	DT
cord-022353-q2k2krnm	547	33	less	less	JJR
cord-022353-q2k2krnm	547	34	than	than	IN
cord-022353-q2k2krnm	547	35	0.01	0.01	CD
cord-022353-q2k2krnm	547	36	mg	mg	NNS
cord-022353-q2k2krnm	547	37	/	/	SYM
cord-022353-q2k2krnm	547	38	ml	ml	NNP
cord-022353-q2k2krnm	547	39	(	(	-LRB-
cord-022353-q2k2krnm	547	40	Bankert	Bankert	NNP
cord-022353-q2k2krnm	547	41	and	and	CC
cord-022353-q2k2krnm	547	42	Mazzaferro	Mazzaferro	NNP
cord-022353-q2k2krnm	547	43	1999	1999	CD
cord-022353-q2k2krnm	547	44	)	)	-RRB-
cord-022353-q2k2krnm	547	45	.	.	.
cord-022353-q2k2krnm	548	1	In	in	IN
cord-022353-q2k2krnm	548	2	addition	addition	NN
cord-022353-q2k2krnm	548	3	,	,	,
cord-022353-q2k2krnm	548	4	there	there	EX
cord-022353-q2k2krnm	548	5	are	be	VBP
cord-022353-q2k2krnm	548	6	many	many	JJ
cord-022353-q2k2krnm	548	7	commercial	commercial	JJ
cord-022353-q2k2krnm	548	8	sources	source	NNS
cord-022353-q2k2krnm	548	9	of	of	IN
cord-022353-q2k2krnm	548	10	enzyme	enzyme	NN
cord-022353-q2k2krnm	548	11	-	-	HYPH
cord-022353-q2k2krnm	548	12	linked	link	VBN
cord-022353-q2k2krnm	548	13	antibodies	antibody	NNS
cord-022353-q2k2krnm	548	14	that	that	WDT
cord-022353-q2k2krnm	548	15	supply	supply	VBP
cord-022353-q2k2krnm	548	16	reagents	reagent	NNS
cord-022353-q2k2krnm	548	17	(	(	-LRB-
cord-022353-q2k2krnm	548	18	and	and	CC
cord-022353-q2k2krnm	548	19	instructions	instruction	NNS
cord-022353-q2k2krnm	548	20	)	)	-RRB-
cord-022353-q2k2krnm	548	21	for	for	IN
cord-022353-q2k2krnm	548	22	developing	develop	VBG
cord-022353-q2k2krnm	548	23	assays	assay	NNS
cord-022353-q2k2krnm	548	24	to	to	TO
cord-022353-q2k2krnm	548	25	measure	measure	VB
cord-022353-q2k2krnm	548	26	antigen	antigen	NN
cord-022353-q2k2krnm	548	27	-	-	HYPH
cord-022353-q2k2krnm	548	28	specific	specific	JJ
cord-022353-q2k2krnm	548	29	antibody	antibody	NN
cord-022353-q2k2krnm	548	30	concentrations	concentration	NNS
cord-022353-q2k2krnm	548	31	by	by	IN
cord-022353-q2k2krnm	548	32	subclass	subclass	NN
cord-022353-q2k2krnm	548	33	of	of	IN
cord-022353-q2k2krnm	548	34	antibody	antibody	NN
cord-022353-q2k2krnm	548	35	.	.	.
cord-022353-q2k2krnm	549	1	The	the	DT
cord-022353-q2k2krnm	549	2	complement	complement	NN
cord-022353-q2k2krnm	549	3	system	system	NN
cord-022353-q2k2krnm	549	4	is	be	VBZ
cord-022353-q2k2krnm	549	5	composed	compose	VBN
cord-022353-q2k2krnm	549	6	of	of	IN
cord-022353-q2k2krnm	549	7	40	40	CD
cord-022353-q2k2krnm	549	8	or	or	CC
cord-022353-q2k2krnm	549	9	more	more	RBR
cord-022353-q2k2krnm	549	10	chemically	chemically	RB
cord-022353-q2k2krnm	549	11	and	and	CC
cord-022353-q2k2krnm	549	12	immunologically	immunologically	RB
cord-022353-q2k2krnm	549	13	distinct	distinct	JJ
cord-022353-q2k2krnm	549	14	proteins	protein	NNS
cord-022353-q2k2krnm	549	15	capable	capable	JJ
cord-022353-q2k2krnm	549	16	of	of	IN
cord-022353-q2k2krnm	549	17	interacting	interact	VBG
cord-022353-q2k2krnm	549	18	with	with	IN
cord-022353-q2k2krnm	549	19	antibodies	antibody	NNS
cord-022353-q2k2krnm	549	20	,	,	,
cord-022353-q2k2krnm	549	21	certain	certain	JJ
cord-022353-q2k2krnm	549	22	bacterial	bacterial	JJ
cord-022353-q2k2krnm	549	23	products	product	NNS
cord-022353-q2k2krnm	549	24	,	,	,
cord-022353-q2k2krnm	549	25	and	and	CC
cord-022353-q2k2krnm	549	26	cell	cell	NN
cord-022353-q2k2krnm	549	27	membranes	membrane	NNS
cord-022353-q2k2krnm	549	28	.	.	.
cord-022353-q2k2krnm	550	1	A	a	DT
cord-022353-q2k2krnm	550	2	brief	brief	JJ
cord-022353-q2k2krnm	550	3	summary	summary	NN
cord-022353-q2k2krnm	550	4	of	of	IN
cord-022353-q2k2krnm	550	5	this	this	DT
cord-022353-q2k2krnm	550	6	system	system	NN
cord-022353-q2k2krnm	550	7	is	be	VBZ
cord-022353-q2k2krnm	550	8	described	describe	VBN
cord-022353-q2k2krnm	550	9	later	later	RB
cord-022353-q2k2krnm	550	10	.	.	.
cord-022353-q2k2krnm	551	1	Please	please	UH
cord-022353-q2k2krnm	551	2	refer	refer	VB
cord-022353-q2k2krnm	551	3	to	to	IN
cord-022353-q2k2krnm	551	4	two	two	CD
cord-022353-q2k2krnm	551	5	recent	recent	JJ
cord-022353-q2k2krnm	551	6	publications	publication	NNS
cord-022353-q2k2krnm	551	7	(	(	-LRB-
cord-022353-q2k2krnm	551	8	Quimby	Quimby	NNP
cord-022353-q2k2krnm	551	9	1999a	1999a	CD
cord-022353-q2k2krnm	551	10	;	;	:
cord-022353-q2k2krnm	551	11	Turnberg	Turnberg	NNP
cord-022353-q2k2krnm	551	12	and	and	CC
cord-022353-q2k2krnm	551	13	Botto	Botto	NNP
cord-022353-q2k2krnm	551	14	2003	2003	CD
cord-022353-q2k2krnm	551	15	)	)	-RRB-
cord-022353-q2k2krnm	551	16	for	for	IN
cord-022353-q2k2krnm	551	17	more	more	JJR
cord-022353-q2k2krnm	551	18	details	detail	NNS
cord-022353-q2k2krnm	551	19	about	about	IN
cord-022353-q2k2krnm	551	20	the	the	DT
cord-022353-q2k2krnm	551	21	structural	structural	JJ
cord-022353-q2k2krnm	551	22	and	and	CC
cord-022353-q2k2krnm	551	23	functional	functional	JJ
cord-022353-q2k2krnm	551	24	aspects	aspect	NNS
cord-022353-q2k2krnm	551	25	of	of	IN
cord-022353-q2k2krnm	551	26	each	each	DT
cord-022353-q2k2krnm	551	27	protein	protein	NN
cord-022353-q2k2krnm	551	28	of	of	IN
cord-022353-q2k2krnm	551	29	the	the	DT
cord-022353-q2k2krnm	551	30	complement	complement	JJ
cord-022353-q2k2krnm	551	31	system	system	NN
cord-022353-q2k2krnm	551	32	.	.	.
cord-022353-q2k2krnm	552	1	The	the	DT
cord-022353-q2k2krnm	552	2	role	role	NN
cord-022353-q2k2krnm	552	3	of	of	IN
cord-022353-q2k2krnm	552	4	the	the	DT
cord-022353-q2k2krnm	552	5	complement	complement	JJ
cord-022353-q2k2krnm	552	6	system	system	NN
cord-022353-q2k2krnm	552	7	in	in	IN
cord-022353-q2k2krnm	552	8	mouse	mouse	NN
cord-022353-q2k2krnm	552	9	immunity	immunity	NN
cord-022353-q2k2krnm	552	10	is	be	VBZ
cord-022353-q2k2krnm	552	11	described	describe	VBN
cord-022353-q2k2krnm	552	12	in	in	IN
cord-022353-q2k2krnm	552	13	Volume	volume	NN
cord-022353-q2k2krnm	552	14	4	4	CD
cord-022353-q2k2krnm	552	15	(	(	-LRB-
cord-022353-q2k2krnm	552	16	Overview	Overview	NNP
cord-022353-q2k2krnm	552	17	)	)	-RRB-
cord-022353-q2k2krnm	552	18	of	of	IN
cord-022353-q2k2krnm	552	19	this	this	DT
cord-022353-q2k2krnm	552	20	series	series	NN
cord-022353-q2k2krnm	552	21	.	.	.
cord-022353-q2k2krnm	553	1	The	the	DT
cord-022353-q2k2krnm	553	2	sequential	sequential	JJ
cord-022353-q2k2krnm	553	3	activation	activation	NN
cord-022353-q2k2krnm	553	4	of	of	IN
cord-022353-q2k2krnm	553	5	individual	individual	JJ
cord-022353-q2k2krnm	553	6	complement	complement	NN
cord-022353-q2k2krnm	553	7	proteins	protein	NNS
cord-022353-q2k2krnm	553	8	from	from	IN
cord-022353-q2k2krnm	553	9	inactive	inactive	JJ
cord-022353-q2k2krnm	553	10	to	to	IN
cord-022353-q2k2krnm	553	11	active	active	JJ
cord-022353-q2k2krnm	553	12	substances	substance	NNS
cord-022353-q2k2krnm	553	13	is	be	VBZ
cord-022353-q2k2krnm	553	14	a	a	DT
cord-022353-q2k2krnm	553	15	dynamic	dynamic	JJ
cord-022353-q2k2krnm	553	16	event	event	NN
cord-022353-q2k2krnm	553	17	called	call	VBN
cord-022353-q2k2krnm	553	18	the	the	DT
cord-022353-q2k2krnm	553	19	complement	complement	NN
cord-022353-q2k2krnm	553	20	cascade	cascade	NN
cord-022353-q2k2krnm	553	21	.	.	.
cord-022353-q2k2krnm	554	1	The	the	DT
cord-022353-q2k2krnm	554	2	ability	ability	NN
cord-022353-q2k2krnm	554	3	of	of	IN
cord-022353-q2k2krnm	554	4	the	the	DT
cord-022353-q2k2krnm	554	5	first	first	JJ
cord-022353-q2k2krnm	554	6	component	component	NN
cord-022353-q2k2krnm	554	7	of	of	IN
cord-022353-q2k2krnm	554	8	complement	complement	NN
cord-022353-q2k2krnm	554	9	,	,	,
cord-022353-q2k2krnm	554	10	C1	C1	NNP
cord-022353-q2k2krnm	554	11	,	,	,
cord-022353-q2k2krnm	554	12	to	to	TO
cord-022353-q2k2krnm	554	13	bind	bind	VB
cord-022353-q2k2krnm	554	14	specific	specific	JJ
cord-022353-q2k2krnm	554	15	sites	site	NNS
cord-022353-q2k2krnm	554	16	on	on	IN
cord-022353-q2k2krnm	554	17	the	the	DT
cord-022353-q2k2krnm	554	18	heavy	heavy	JJ
cord-022353-q2k2krnm	554	19	chain	chain	NN
cord-022353-q2k2krnm	554	20	of	of	IN
cord-022353-q2k2krnm	554	21	mouse	mouse	NN
cord-022353-q2k2krnm	554	22	IgG2b	IgG2b	NNP
cord-022353-q2k2krnm	554	23	and	and	CC
cord-022353-q2k2krnm	554	24	activate	activate	VB
cord-022353-q2k2krnm	554	25	a	a	DT
cord-022353-q2k2krnm	554	26	sequence	sequence	NN
cord-022353-q2k2krnm	554	27	of	of	IN
cord-022353-q2k2krnm	554	28	reactions	reaction	NNS
cord-022353-q2k2krnm	554	29	leading	lead	VBG
cord-022353-q2k2krnm	554	30	to	to	IN
cord-022353-q2k2krnm	554	31	production	production	NN
cord-022353-q2k2krnm	554	32	of	of	IN
cord-022353-q2k2krnm	554	33	a	a	DT
cord-022353-q2k2krnm	554	34	molecular	molecular	JJ
cord-022353-q2k2krnm	554	35	unit	unit	NN
cord-022353-q2k2krnm	554	36	capable	capable	JJ
cord-022353-q2k2krnm	554	37	of	of	IN
cord-022353-q2k2krnm	554	38	lysing	lyse	VBG
cord-022353-q2k2krnm	554	39	a	a	DT
cord-022353-q2k2krnm	554	40	target	target	NN
cord-022353-q2k2krnm	554	41	cell	cell	NN
cord-022353-q2k2krnm	554	42	membrane	membrane	NN
cord-022353-q2k2krnm	554	43	has	have	VBZ
cord-022353-q2k2krnm	554	44	established	establish	VBN
cord-022353-q2k2krnm	554	45	the	the	DT
cord-022353-q2k2krnm	554	46	complement	complement	NN
cord-022353-q2k2krnm	554	47	system	system	NN
cord-022353-q2k2krnm	554	48	as	as	IN
cord-022353-q2k2krnm	554	49	the	the	DT
cord-022353-q2k2krnm	554	50	primary	primary	JJ
cord-022353-q2k2krnm	554	51	mediator	mediator	NN
cord-022353-q2k2krnm	554	52	of	of	IN
cord-022353-q2k2krnm	554	53	antibody	antibody	NN
cord-022353-q2k2krnm	554	54	-	-	HYPH
cord-022353-q2k2krnm	554	55	antigen	antigen	NN
cord-022353-q2k2krnm	554	56	reactions	reaction	NNS
cord-022353-q2k2krnm	554	57	.	.	.
cord-022353-q2k2krnm	555	1	Recent	recent	JJ
cord-022353-q2k2krnm	555	2	findings	finding	NNS
cord-022353-q2k2krnm	555	3	suggest	suggest	VBP
cord-022353-q2k2krnm	555	4	that	that	IN
cord-022353-q2k2krnm	555	5	the	the	DT
cord-022353-q2k2krnm	555	6	pentraxins	pentraxin	NNS
cord-022353-q2k2krnm	555	7	,	,	,
cord-022353-q2k2krnm	555	8	C	C	NNP
cord-022353-q2k2krnm	555	9	-	-	HYPH
cord-022353-q2k2krnm	555	10	reactive	reactive	JJ
cord-022353-q2k2krnm	555	11	protein	protein	NN
cord-022353-q2k2krnm	555	12	(	(	-LRB-
cord-022353-q2k2krnm	555	13	CRP	CRP	NNP
cord-022353-q2k2krnm	555	14	)	)	-RRB-
cord-022353-q2k2krnm	555	15	,	,	,
cord-022353-q2k2krnm	555	16	serum	serum	NN
cord-022353-q2k2krnm	555	17	amyloid	amyloid	NN
cord-022353-q2k2krnm	555	18	protein	protein	NN
cord-022353-q2k2krnm	555	19	(	(	-LRB-
cord-022353-q2k2krnm	555	20	SAP	SAP	NNP
cord-022353-q2k2krnm	555	21	)	)	-RRB-
cord-022353-q2k2krnm	555	22	,	,	,
cord-022353-q2k2krnm	555	23	and	and	CC
cord-022353-q2k2krnm	555	24	pentraxin	pentraxin	NNP
cord-022353-q2k2krnm	555	25	3	3	CD
cord-022353-q2k2krnm	555	26	(	(	-LRB-
cord-022353-q2k2krnm	555	27	PTX3	PTX3	NNP
cord-022353-q2k2krnm	555	28	)	)	-RRB-
cord-022353-q2k2krnm	555	29	can	can	MD
cord-022353-q2k2krnm	555	30	bind	bind	VB
cord-022353-q2k2krnm	555	31	to	to	TO
cord-022353-q2k2krnm	555	32	complement	complement	VB
cord-022353-q2k2krnm	555	33	component	component	NN
cord-022353-q2k2krnm	555	34	Clq	Clq	NNP
cord-022353-q2k2krnm	555	35	and	and	CC
cord-022353-q2k2krnm	555	36	activate	activate	VB
cord-022353-q2k2krnm	555	37	the	the	DT
cord-022353-q2k2krnm	555	38	classical	classical	JJ
cord-022353-q2k2krnm	555	39	pathway	pathway	NN
cord-022353-q2k2krnm	555	40	.	.	.
cord-022353-q2k2krnm	556	1	This	this	DT
cord-022353-q2k2krnm	556	2	may	may	MD
cord-022353-q2k2krnm	556	3	be	be	VB
cord-022353-q2k2krnm	556	4	an	an	DT
cord-022353-q2k2krnm	556	5	important	important	JJ
cord-022353-q2k2krnm	556	6	mechanism	mechanism	NN
cord-022353-q2k2krnm	556	7	for	for	IN
cord-022353-q2k2krnm	556	8	removal	removal	NN
cord-022353-q2k2krnm	556	9	of	of	IN
cord-022353-q2k2krnm	556	10	apoptotic	apoptotic	JJ
cord-022353-q2k2krnm	556	11	cells	cell	NNS
cord-022353-q2k2krnm	556	12	that	that	WDT
cord-022353-q2k2krnm	556	13	might	may	MD
cord-022353-q2k2krnm	556	14	otherwise	otherwise	RB
cord-022353-q2k2krnm	556	15	predispose	predispose	VB
cord-022353-q2k2krnm	556	16	to	to	IN
cord-022353-q2k2krnm	556	17	autoimmune	autoimmune	JJ
cord-022353-q2k2krnm	556	18	disease	disease	NN
cord-022353-q2k2krnm	557	1	(	(	-LRB-
cord-022353-q2k2krnm	557	2	Nauta	Nauta	NNP
cord-022353-q2k2krnm	557	3	et	et	FW
cord-022353-q2k2krnm	557	4	al	al	NNP
cord-022353-q2k2krnm	557	5	.	.	NNP
cord-022353-q2k2krnm	557	6	2003	2003	CD
cord-022353-q2k2krnm	557	7	)	)	-RRB-
cord-022353-q2k2krnm	557	8	.	.	.
cord-022353-q2k2krnm	558	1	Each	each	DT
cord-022353-q2k2krnm	558	2	protein	protein	NN
cord-022353-q2k2krnm	558	3	of	of	IN
cord-022353-q2k2krnm	558	4	the	the	DT
cord-022353-q2k2krnm	558	5	complement	complement	JJ
cord-022353-q2k2krnm	558	6	system	system	NN
cord-022353-q2k2krnm	558	7	is	be	VBZ
cord-022353-q2k2krnm	558	8	normally	normally	RB
cord-022353-q2k2krnm	558	9	present	present	JJ
cord-022353-q2k2krnm	558	10	in	in	IN
cord-022353-q2k2krnm	558	11	the	the	DT
cord-022353-q2k2krnm	558	12	circulation	circulation	NN
cord-022353-q2k2krnm	558	13	as	as	IN
cord-022353-q2k2krnm	558	14	an	an	DT
cord-022353-q2k2krnm	558	15	inactive	inactive	JJ
cord-022353-q2k2krnm	558	16	molecule	molecule	NN
cord-022353-q2k2krnm	558	17	.	.	.
cord-022353-q2k2krnm	559	1	Although	although	IN
cord-022353-q2k2krnm	559	2	the	the	DT
cord-022353-q2k2krnm	559	3	complement	complement	NN
cord-022353-q2k2krnm	559	4	cascade	cascade	NN
cord-022353-q2k2krnm	559	5	may	may	MD
cord-022353-q2k2krnm	559	6	be	be	VB
cord-022353-q2k2krnm	559	7	activated	activate	VBN
cord-022353-q2k2krnm	559	8	by	by	IN
cord-022353-q2k2krnm	559	9	any	any	DT
cord-022353-q2k2krnm	559	10	of	of	IN
cord-022353-q2k2krnm	559	11	four	four	CD
cord-022353-q2k2krnm	559	12	separate	separate	JJ
cord-022353-q2k2krnm	559	13	pathways	pathway	NNS
cord-022353-q2k2krnm	559	14	,	,	,
cord-022353-q2k2krnm	559	15	the	the	DT
cord-022353-q2k2krnm	559	16	central	central	JJ
cord-022353-q2k2krnm	559	17	event	event	NN
cord-022353-q2k2krnm	559	18	for	for	IN
cord-022353-q2k2krnm	559	19	each	each	DT
cord-022353-q2k2krnm	559	20	is	be	VBZ
cord-022353-q2k2krnm	559	21	activation	activation	NN
cord-022353-q2k2krnm	559	22	of	of	IN
cord-022353-q2k2krnm	559	23	C3	C3	NNP
cord-022353-q2k2krnm	559	24	to	to	IN
cord-022353-q2k2krnm	559	25	C3b	c3b	NN
cord-022353-q2k2krnm	559	26	yielding	yield	VBG
cord-022353-q2k2krnm	559	27	a	a	DT
cord-022353-q2k2krnm	559	28	small	small	JJ
cord-022353-q2k2krnm	559	29	C3	c3	NN
cord-022353-q2k2krnm	559	30	cz	cz	NN
cord-022353-q2k2krnm	559	31	chain	chain	NN
cord-022353-q2k2krnm	559	32	fragment	fragment	NN
cord-022353-q2k2krnm	559	33	.	.	.
cord-022353-q2k2krnm	560	1	The	the	DT
cord-022353-q2k2krnm	560	2	two	two	CD
cord-022353-q2k2krnm	560	3	C3	c3	NN
cord-022353-q2k2krnm	560	4	convertases	convertase	NNS
cord-022353-q2k2krnm	560	5	are	be	VBP
cord-022353-q2k2krnm	560	6	C4b2a	C4b2a	NNP
cord-022353-q2k2krnm	560	7	(	(	-LRB-
cord-022353-q2k2krnm	560	8	for	for	IN
cord-022353-q2k2krnm	560	9	the	the	DT
cord-022353-q2k2krnm	560	10	classical	classical	JJ
cord-022353-q2k2krnm	560	11	,	,	,
cord-022353-q2k2krnm	560	12	lectin	lectin	NN
cord-022353-q2k2krnm	560	13	,	,	,
cord-022353-q2k2krnm	560	14	or	or	CC
cord-022353-q2k2krnm	560	15	pentraxin	pentraxin	NN
cord-022353-q2k2krnm	560	16	pathways	pathway	NNS
cord-022353-q2k2krnm	560	17	)	)	-RRB-
cord-022353-q2k2krnm	560	18	and	and	CC
cord-022353-q2k2krnm	560	19	C3bBb	C3bBb	NNP
cord-022353-q2k2krnm	560	20	for	for	IN
cord-022353-q2k2krnm	560	21	the	the	DT
cord-022353-q2k2krnm	560	22	alternative	alternative	JJ
cord-022353-q2k2krnm	560	23	pathway	pathway	NN
cord-022353-q2k2krnm	560	24	.	.	.
cord-022353-q2k2krnm	561	1	Each	each	DT
cord-022353-q2k2krnm	561	2	C3	c3	NN
cord-022353-q2k2krnm	561	3	convertase	convertase	NN
cord-022353-q2k2krnm	561	4	cleaves	cleave	VBZ
cord-022353-q2k2krnm	561	5	C3	C3	NNP
cord-022353-q2k2krnm	561	6	and	and	CC
cord-022353-q2k2krnm	561	7	adds	add	VBZ
cord-022353-q2k2krnm	561	8	the	the	DT
cord-022353-q2k2krnm	561	9	C3b	C3b	NNP
cord-022353-q2k2krnm	561	10	fragment	fragment	NN
cord-022353-q2k2krnm	561	11	to	to	IN
cord-022353-q2k2krnm	561	12	the	the	DT
cord-022353-q2k2krnm	561	13	convertase	convertase	NN
cord-022353-q2k2krnm	561	14	complex	complex	NN
cord-022353-q2k2krnm	561	15	forming	form	VBG
cord-022353-q2k2krnm	561	16	C5	C5	NNP
cord-022353-q2k2krnm	561	17	convertase	convertase	NN
cord-022353-q2k2krnm	561	18	.	.	.
cord-022353-q2k2krnm	562	1	Cleavage	cleavage	NN
cord-022353-q2k2krnm	562	2	of	of	IN
cord-022353-q2k2krnm	562	3	C5	C5	NNP
cord-022353-q2k2krnm	562	4	leads	lead	VBZ
cord-022353-q2k2krnm	562	5	to	to	IN
cord-022353-q2k2krnm	562	6	the	the	DT
cord-022353-q2k2krnm	562	7	membrane	membrane	NN
cord-022353-q2k2krnm	562	8	attack	attack	NN
cord-022353-q2k2krnm	562	9	complex	complex	NN
cord-022353-q2k2krnm	562	10	(	(	-LRB-
cord-022353-q2k2krnm	562	11	MAC	MAC	NNP
cord-022353-q2k2krnm	562	12	)	)	-RRB-
cord-022353-q2k2krnm	562	13	common	common	JJ
cord-022353-q2k2krnm	562	14	to	to	IN
cord-022353-q2k2krnm	562	15	all	all	DT
cord-022353-q2k2krnm	562	16	activation	activation	NN
cord-022353-q2k2krnm	562	17	pathways	pathway	NNS
cord-022353-q2k2krnm	563	1	(	(	-LRB-
cord-022353-q2k2krnm	563	2	Goldsby	Goldsby	NNP
cord-022353-q2k2krnm	563	3	et	et	NNP
cord-022353-q2k2krnm	563	4	al	al	NNP
cord-022353-q2k2krnm	563	5	.	.	NNP
cord-022353-q2k2krnm	563	6	2003	2003	CD
cord-022353-q2k2krnm	563	7	)	)	-RRB-
cord-022353-q2k2krnm	563	8	.	.	.
cord-022353-q2k2krnm	564	1	Assemblage	assemblage	NN
cord-022353-q2k2krnm	564	2	of	of	IN
cord-022353-q2k2krnm	564	3	the	the	DT
cord-022353-q2k2krnm	564	4	MAC	MAC	NNP
cord-022353-q2k2krnm	564	5	on	on	IN
cord-022353-q2k2krnm	564	6	the	the	DT
cord-022353-q2k2krnm	564	7	surface	surface	NN
cord-022353-q2k2krnm	564	8	of	of	IN
cord-022353-q2k2krnm	564	9	a	a	DT
cord-022353-q2k2krnm	564	10	target	target	NN
cord-022353-q2k2krnm	564	11	cell	cell	NN
cord-022353-q2k2krnm	564	12	leads	lead	VBZ
cord-022353-q2k2krnm	564	13	to	to	IN
cord-022353-q2k2krnm	564	14	the	the	DT
cord-022353-q2k2krnm	564	15	formation	formation	NN
cord-022353-q2k2krnm	564	16	of	of	IN
cord-022353-q2k2krnm	564	17	a	a	DT
cord-022353-q2k2krnm	564	18	large	large	JJ
cord-022353-q2k2krnm	564	19	channel	channel	NN
cord-022353-q2k2krnm	564	20	enabling	enable	VBG
cord-022353-q2k2krnm	564	21	ions	ion	NNS
cord-022353-q2k2krnm	564	22	and	and	CC
cord-022353-q2k2krnm	564	23	other	other	JJ
cord-022353-q2k2krnm	564	24	small	small	JJ
cord-022353-q2k2krnm	564	25	molecules	molecule	NNS
cord-022353-q2k2krnm	564	26	to	to	TO
cord-022353-q2k2krnm	564	27	diffuse	diffuse	VB
cord-022353-q2k2krnm	564	28	out	out	RP
cord-022353-q2k2krnm	564	29	leading	lead	VBG
cord-022353-q2k2krnm	564	30	to	to	IN
cord-022353-q2k2krnm	564	31	cell	cell	NN
cord-022353-q2k2krnm	564	32	death	death	NN
cord-022353-q2k2krnm	564	33	.	.	.
cord-022353-q2k2krnm	565	1	The	the	DT
cord-022353-q2k2krnm	565	2	activated	activate	VBN
cord-022353-q2k2krnm	565	3	components	component	NNS
cord-022353-q2k2krnm	565	4	of	of	IN
cord-022353-q2k2krnm	565	5	complement	complement	NN
cord-022353-q2k2krnm	565	6	also	also	RB
cord-022353-q2k2krnm	565	7	participate	participate	VBP
cord-022353-q2k2krnm	565	8	in	in	IN
cord-022353-q2k2krnm	565	9	chemotaxis	chemotaxis	NN
cord-022353-q2k2krnm	565	10	,	,	,
cord-022353-q2k2krnm	565	11	phagocytosis	phagocytosis	NN
cord-022353-q2k2krnm	565	12	,	,	,
cord-022353-q2k2krnm	565	13	cell	cell	NN
cord-022353-q2k2krnm	565	14	adhesion	adhesion	NN
cord-022353-q2k2krnm	565	15	,	,	,
cord-022353-q2k2krnm	565	16	and	and	CC
cord-022353-q2k2krnm	565	17	B	b	NN
cord-022353-q2k2krnm	565	18	-	-	HYPH
cord-022353-q2k2krnm	565	19	cell	cell	NN
cord-022353-q2k2krnm	565	20	differentiation	differentiation	NN
cord-022353-q2k2krnm	565	21	.	.	.
cord-022353-q2k2krnm	566	1	There	there	EX
cord-022353-q2k2krnm	566	2	are	be	VBP
cord-022353-q2k2krnm	566	3	many	many	JJ
cord-022353-q2k2krnm	566	4	notable	notable	JJ
cord-022353-q2k2krnm	566	5	differences	difference	NNS
cord-022353-q2k2krnm	566	6	between	between	IN
cord-022353-q2k2krnm	566	7	mice	mouse	NNS
cord-022353-q2k2krnm	566	8	and	and	CC
cord-022353-q2k2krnm	566	9	humans	human	NNS
cord-022353-q2k2krnm	566	10	regarding	regard	VBG
cord-022353-q2k2krnm	566	11	expression	expression	NN
cord-022353-q2k2krnm	566	12	of	of	IN
cord-022353-q2k2krnm	566	13	complement	complement	JJ
cord-022353-q2k2krnm	566	14	components	component	NNS
cord-022353-q2k2krnm	566	15	and	and	CC
cord-022353-q2k2krnm	566	16	regulation	regulation	NN
cord-022353-q2k2krnm	566	17	of	of	IN
cord-022353-q2k2krnm	566	18	cascade	cascade	NN
cord-022353-q2k2krnm	566	19	activation	activation	NN
cord-022353-q2k2krnm	566	20	.	.	.
cord-022353-q2k2krnm	567	1	Mice	mouse	NNS
cord-022353-q2k2krnm	567	2	have	have	VBP
cord-022353-q2k2krnm	567	3	both	both	CC
cord-022353-q2k2krnm	567	4	an	an	DT
cord-022353-q2k2krnm	567	5	active	active	JJ
cord-022353-q2k2krnm	567	6	and	and	CC
cord-022353-q2k2krnm	567	7	inactive	inactive	JJ
cord-022353-q2k2krnm	567	8	form	form	NN
cord-022353-q2k2krnm	567	9	of	of	IN
cord-022353-q2k2krnm	567	10	circulating	circulate	VBG
cord-022353-q2k2krnm	567	11	C4	c4	NN
cord-022353-q2k2krnm	567	12	and	and	CC
cord-022353-q2k2krnm	567	13	the	the	DT
cord-022353-q2k2krnm	567	14	genes	gene	NNS
cord-022353-q2k2krnm	567	15	(	(	-LRB-
cord-022353-q2k2krnm	567	16	both	both	DT
cord-022353-q2k2krnm	567	17	on	on	IN
cord-022353-q2k2krnm	567	18	chromosome	chromosome	NN
cord-022353-q2k2krnm	567	19	17	17	CD
cord-022353-q2k2krnm	567	20	)	)	-RRB-
cord-022353-q2k2krnm	567	21	are	be	VBP
cord-022353-q2k2krnm	567	22	designated	designate	VBN
cord-022353-q2k2krnm	567	23	Ss	Ss	NNP
cord-022353-q2k2krnm	567	24	and	and	CC
cord-022353-q2k2krnm	567	25	Slp	Slp	NNP
cord-022353-q2k2krnm	567	26	,	,	,
cord-022353-q2k2krnm	567	27	respectively	respectively	RB
cord-022353-q2k2krnm	567	28	.	.	.
cord-022353-q2k2krnm	568	1	Many	many	JJ
cord-022353-q2k2krnm	568	2	inbred	inbred	JJ
cord-022353-q2k2krnm	568	3	strains	strain	NNS
cord-022353-q2k2krnm	568	4	do	do	VBP
cord-022353-q2k2krnm	568	5	not	not	RB
cord-022353-q2k2krnm	568	6	synthesize	synthesize	VB
cord-022353-q2k2krnm	568	7	active	active	JJ
cord-022353-q2k2krnm	568	8	C5	c5	NN
cord-022353-q2k2krnm	568	9	(	(	-LRB-
cord-022353-q2k2krnm	568	10	e.g.	e.g.	RB
cord-022353-q2k2krnm	568	11	,	,	,
cord-022353-q2k2krnm	568	12	DBA/2	DBA/2	NNP
cord-022353-q2k2krnm	568	13	and	and	CC
cord-022353-q2k2krnm	568	14	A	A	NNP
cord-022353-q2k2krnm	568	15	/	/	SYM
cord-022353-q2k2krnm	568	16	J	J	NNP
cord-022353-q2k2krnm	568	17	strain	strain	VBP
cord-022353-q2k2krnm	568	18	)	)	-RRB-
cord-022353-q2k2krnm	568	19	due	due	IN
cord-022353-q2k2krnm	568	20	to	to	IN
cord-022353-q2k2krnm	568	21	a	a	DT
cord-022353-q2k2krnm	568	22	post	post	JJ
cord-022353-q2k2krnm	568	23	-	-	JJ
cord-022353-q2k2krnm	568	24	translational	translational	JJ
cord-022353-q2k2krnm	568	25	defect	defect	NN
cord-022353-q2k2krnm	568	26	and	and	CC
cord-022353-q2k2krnm	568	27	therefore	therefore	RB
cord-022353-q2k2krnm	568	28	they	-PRON-	PRP
cord-022353-q2k2krnm	568	29	can	can	MD
cord-022353-q2k2krnm	568	30	not	not	RB
cord-022353-q2k2krnm	568	31	generate	generate	VB
cord-022353-q2k2krnm	568	32	a	a	DT
cord-022353-q2k2krnm	568	33	MAC	mac	NN
cord-022353-q2k2krnm	568	34	.	.	.
cord-022353-q2k2krnm	569	1	Some	some	DT
cord-022353-q2k2krnm	569	2	strains	strain	NNS
cord-022353-q2k2krnm	569	3	are	be	VBP
cord-022353-q2k2krnm	569	4	deficient	deficient	JJ
cord-022353-q2k2krnm	569	5	in	in	IN
cord-022353-q2k2krnm	569	6	the	the	DT
cord-022353-q2k2krnm	569	7	production	production	NN
cord-022353-q2k2krnm	569	8	of	of	IN
cord-022353-q2k2krnm	569	9	C8	c8	NN
cord-022353-q2k2krnm	569	10	(	(	-LRB-
cord-022353-q2k2krnm	569	11	e.g.	e.g.	RB
cord-022353-q2k2krnm	569	12	,	,	,
cord-022353-q2k2krnm	569	13	DBA/2J	dba/2j	NN
cord-022353-q2k2krnm	569	14	strain	strain	NN
cord-022353-q2k2krnm	569	15	)	)	-RRB-
cord-022353-q2k2krnm	569	16	.	.	.
cord-022353-q2k2krnm	570	1	Complement	complement	JJ
cord-022353-q2k2krnm	570	2	component	component	NN
cord-022353-q2k2krnm	570	3	6	6	CD
cord-022353-q2k2krnm	570	4	exists	exist	VBZ
cord-022353-q2k2krnm	570	5	as	as	IN
cord-022353-q2k2krnm	570	6	two	two	CD
cord-022353-q2k2krnm	570	7	allelic	allelic	JJ
cord-022353-q2k2krnm	570	8	forms	form	NNS
cord-022353-q2k2krnm	570	9	in	in	IN
cord-022353-q2k2krnm	570	10	mice	mouse	NNS
cord-022353-q2k2krnm	570	11	with	with	IN
cord-022353-q2k2krnm	570	12	90	90	CD
cord-022353-q2k2krnm	570	13	and	and	CC
cord-022353-q2k2krnm	570	14	100	100	CD
cord-022353-q2k2krnm	570	15	kDa	kDa	NNP
cord-022353-q2k2krnm	570	16	molecular	molecular	JJ
cord-022353-q2k2krnm	570	17	weights	weight	NNS
cord-022353-q2k2krnm	570	18	.	.	.
cord-022353-q2k2krnm	571	1	Similarly	similarly	RB
cord-022353-q2k2krnm	571	2	there	there	EX
cord-022353-q2k2krnm	571	3	are	be	VBP
cord-022353-q2k2krnm	571	4	several	several	JJ
cord-022353-q2k2krnm	571	5	notable	notable	JJ
cord-022353-q2k2krnm	571	6	differences	difference	NNS
cord-022353-q2k2krnm	571	7	in	in	IN
cord-022353-q2k2krnm	571	8	the	the	DT
cord-022353-q2k2krnm	571	9	regulators	regulator	NNS
cord-022353-q2k2krnm	571	10	of	of	IN
cord-022353-q2k2krnm	571	11	complement	complement	JJ
cord-022353-q2k2krnm	571	12	activation	activation	NN
cord-022353-q2k2krnm	571	13	.	.	.
cord-022353-q2k2krnm	572	1	Most	Most	JJS
cord-022353-q2k2krnm	572	2	of	of	IN
cord-022353-q2k2krnm	572	3	these	these	DT
cord-022353-q2k2krnm	572	4	regulators	regulator	NNS
cord-022353-q2k2krnm	572	5	are	be	VBP
cord-022353-q2k2krnm	572	6	found	find	VBN
cord-022353-q2k2krnm	572	7	in	in	IN
cord-022353-q2k2krnm	572	8	the	the	DT
cord-022353-q2k2krnm	572	9	regulator	regulator	NN
cord-022353-q2k2krnm	572	10	of	of	IN
cord-022353-q2k2krnm	572	11	complement	complement	JJ
cord-022353-q2k2krnm	572	12	activation	activation	NN
cord-022353-q2k2krnm	572	13	(	(	-LRB-
cord-022353-q2k2krnm	572	14	RCA	RCA	NNP
cord-022353-q2k2krnm	572	15	)	)	-RRB-
cord-022353-q2k2krnm	572	16	locus	locus	NN
cord-022353-q2k2krnm	572	17	on	on	IN
cord-022353-q2k2krnm	572	18	murine	murine	JJ
cord-022353-q2k2krnm	572	19	chromosome	chromosome	NN
cord-022353-q2k2krnm	572	20	1	1	CD
cord-022353-q2k2krnm	572	21	and	and	CC
cord-022353-q2k2krnm	572	22	,	,	,
cord-022353-q2k2krnm	572	23	as	as	IN
cord-022353-q2k2krnm	572	24	in	in	IN
cord-022353-q2k2krnm	572	25	humans	human	NNS
cord-022353-q2k2krnm	572	26	,	,	,
cord-022353-q2k2krnm	572	27	restrict	restrict	VB
cord-022353-q2k2krnm	572	28	assembly	assembly	NN
cord-022353-q2k2krnm	572	29	and	and	CC
cord-022353-q2k2krnm	572	30	stability	stability	NN
cord-022353-q2k2krnm	572	31	of	of	IN
cord-022353-q2k2krnm	572	32	convertase	convertase	NN
cord-022353-q2k2krnm	572	33	enzymes	enzyme	NNS
cord-022353-q2k2krnm	572	34	.	.	.
cord-022353-q2k2krnm	573	1	In	in	IN
cord-022353-q2k2krnm	573	2	mice	mouse	NNS
cord-022353-q2k2krnm	573	3	,	,	,
cord-022353-q2k2krnm	573	4	decay	decay	VB
cord-022353-q2k2krnm	573	5	acceleration	acceleration	NN
cord-022353-q2k2krnm	573	6	factor	factor	NN
cord-022353-q2k2krnm	573	7	(	(	-LRB-
cord-022353-q2k2krnm	573	8	DAF	DAF	NNP
cord-022353-q2k2krnm	573	9	)	)	-RRB-
cord-022353-q2k2krnm	573	10	is	be	VBZ
cord-022353-q2k2krnm	573	11	encoded	encode	VBN
cord-022353-q2k2krnm	573	12	by	by	IN
cord-022353-q2k2krnm	573	13	two	two	CD
cord-022353-q2k2krnm	573	14	genes	gene	NNS
cord-022353-q2k2krnm	573	15	.	.	.
cord-022353-q2k2krnm	574	1	However	however	RB
cord-022353-q2k2krnm	574	2	,	,	,
cord-022353-q2k2krnm	574	3	only	only	RB
cord-022353-q2k2krnm	574	4	the	the	DT
cord-022353-q2k2krnm	574	5	product	product	NN
cord-022353-q2k2krnm	574	6	of	of	IN
cord-022353-q2k2krnm	574	7	Daf-1	Daf-1	NNP
cord-022353-q2k2krnm	574	8	is	be	VBZ
cord-022353-q2k2krnm	574	9	widely	widely	RB
cord-022353-q2k2krnm	574	10	dispersed	disperse	VBN
cord-022353-q2k2krnm	574	11	on	on	IN
cord-022353-q2k2krnm	574	12	all	all	DT
cord-022353-q2k2krnm	574	13	tissues	tissue	NNS
cord-022353-q2k2krnm	574	14	.	.	.
cord-022353-q2k2krnm	575	1	This	this	DT
cord-022353-q2k2krnm	575	2	membrane	membrane	NN
cord-022353-q2k2krnm	575	3	-	-	HYPH
cord-022353-q2k2krnm	575	4	anchored	anchor	VBN
cord-022353-q2k2krnm	575	5	protein	protein	NN
cord-022353-q2k2krnm	575	6	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	575	7	C3	c3	JJ
cord-022353-q2k2krnm	575	8	cleavage	cleavage	NN
cord-022353-q2k2krnm	575	9	by	by	IN
cord-022353-q2k2krnm	575	10	accelerating	accelerate	VBG
cord-022353-q2k2krnm	575	11	decay	decay	NN
cord-022353-q2k2krnm	575	12	of	of	IN
cord-022353-q2k2krnm	575	13	C3	c3	NN
cord-022353-q2k2krnm	575	14	convertases	convertase	NNS
cord-022353-q2k2krnm	575	15	.	.	.
cord-022353-q2k2krnm	576	1	In	in	IN
cord-022353-q2k2krnm	576	2	mice	mouse	NNS
cord-022353-q2k2krnm	576	3	it	-PRON-	PRP
cord-022353-q2k2krnm	576	4	is	be	VBZ
cord-022353-q2k2krnm	576	5	the	the	DT
cord-022353-q2k2krnm	576	6	major	major	JJ
cord-022353-q2k2krnm	576	7	regulator	regulator	NN
cord-022353-q2k2krnm	576	8	of	of	IN
cord-022353-q2k2krnm	576	9	C3	C3	NNP
cord-022353-q2k2krnm	576	10	in	in	IN
cord-022353-q2k2krnm	576	11	the	the	DT
cord-022353-q2k2krnm	576	12	skin	skin	NN
cord-022353-q2k2krnm	576	13	(	(	-LRB-
cord-022353-q2k2krnm	576	14	not	not	RB
cord-022353-q2k2krnm	576	15	kidney	kidney	NN
cord-022353-q2k2krnm	576	16	)	)	-RRB-
cord-022353-q2k2krnm	576	17	and	and	CC
cord-022353-q2k2krnm	576	18	is	be	VBZ
cord-022353-q2k2krnm	576	19	a	a	DT
cord-022353-q2k2krnm	576	20	ligand	ligand	NN
cord-022353-q2k2krnm	576	21	for	for	IN
cord-022353-q2k2krnm	576	22	CD97	CD97	NNP
cord-022353-q2k2krnm	576	23	which	which	WDT
cord-022353-q2k2krnm	576	24	,	,	,
cord-022353-q2k2krnm	576	25	on	on	IN
cord-022353-q2k2krnm	576	26	cross	cross	NN
cord-022353-q2k2krnm	576	27	-	-	JJ
cord-022353-q2k2krnm	576	28	linking	linking	JJ
cord-022353-q2k2krnm	576	29	,	,	,
cord-022353-q2k2krnm	576	30	leads	lead	VBZ
cord-022353-q2k2krnm	576	31	to	to	IN
cord-022353-q2k2krnm	576	32	lymphocyte	lymphocyte	NN
cord-022353-q2k2krnm	576	33	activation	activation	NN
cord-022353-q2k2krnm	576	34	.	.	.
cord-022353-q2k2krnm	577	1	CD59	CD59	NNP
cord-022353-q2k2krnm	577	2	is	be	VBZ
cord-022353-q2k2krnm	577	3	a	a	DT
cord-022353-q2k2krnm	577	4	membrane	membrane	NN
cord-022353-q2k2krnm	577	5	-	-	HYPH
cord-022353-q2k2krnm	577	6	anchored	anchor	VBN
cord-022353-q2k2krnm	577	7	inhibitor	inhibitor	NN
cord-022353-q2k2krnm	577	8	of	of	IN
cord-022353-q2k2krnm	577	9	C5b-9	C5b-9	``
cord-022353-q2k2krnm	577	10	formation	formation	NN
cord-022353-q2k2krnm	577	11	(	(	-LRB-
cord-022353-q2k2krnm	577	12	MAC	MAC	NNP
cord-022353-q2k2krnm	577	13	)	)	-RRB-
cord-022353-q2k2krnm	577	14	and	and	CC
cord-022353-q2k2krnm	577	15	prevents	prevent	VBZ
cord-022353-q2k2krnm	577	16	C9	C9	NNP
cord-022353-q2k2krnm	577	17	from	from	IN
cord-022353-q2k2krnm	577	18	binding	bind	VBG
cord-022353-q2k2krnm	577	19	the	the	DT
cord-022353-q2k2krnm	577	20	C5b-8	C5b-8	NNP
cord-022353-q2k2krnm	577	21	complex	complex	NN
cord-022353-q2k2krnm	577	22	.	.	.
cord-022353-q2k2krnm	578	1	Deficiencies	deficiency	NNS
cord-022353-q2k2krnm	578	2	of	of	IN
cord-022353-q2k2krnm	578	3	CD59	CD59	NNP
cord-022353-q2k2krnm	578	4	in	in	IN
cord-022353-q2k2krnm	578	5	humans	human	NNS
cord-022353-q2k2krnm	578	6	lead	lead	VBP
cord-022353-q2k2krnm	578	7	to	to	IN
cord-022353-q2k2krnm	578	8	hemolytic	hemolytic	JJ
cord-022353-q2k2krnm	578	9	anemia	anemia	NN
cord-022353-q2k2krnm	578	10	but	but	CC
cord-022353-q2k2krnm	578	11	not	not	RB
cord-022353-q2k2krnm	578	12	in	in	IN
cord-022353-q2k2krnm	578	13	mice	mouse	NNS
cord-022353-q2k2krnm	578	14	.	.	.
cord-022353-q2k2krnm	579	1	Membrane	membrane	NN
cord-022353-q2k2krnm	579	2	cofactor	cofactor	NN
cord-022353-q2k2krnm	579	3	protein	protein	NN
cord-022353-q2k2krnm	579	4	(	(	-LRB-
cord-022353-q2k2krnm	579	5	MCP	MCP	NNP
cord-022353-q2k2krnm	579	6	)	)	-RRB-
cord-022353-q2k2krnm	579	7	is	be	VBZ
cord-022353-q2k2krnm	579	8	a	a	DT
cord-022353-q2k2krnm	579	9	major	major	JJ
cord-022353-q2k2krnm	579	10	cofactor	cofactor	NN
cord-022353-q2k2krnm	579	11	for	for	IN
cord-022353-q2k2krnm	579	12	factor	factor	NN
cord-022353-q2k2krnm	579	13	I	-PRON-	PRP
cord-022353-q2k2krnm	579	14	in	in	IN
cord-022353-q2k2krnm	579	15	humans	human	NNS
cord-022353-q2k2krnm	579	16	causing	cause	VBG
cord-022353-q2k2krnm	579	17	cleavage	cleavage	NN
cord-022353-q2k2krnm	579	18	of	of	IN
cord-022353-q2k2krnm	579	19	C3b	c3b	NN
cord-022353-q2k2krnm	579	20	and	and	CC
cord-022353-q2k2krnm	579	21	C4b	c4b	NN
cord-022353-q2k2krnm	580	1	deposited	deposit	VBN
cord-022353-q2k2krnm	580	2	on	on	IN
cord-022353-q2k2krnm	580	3	self	self	NN
cord-022353-q2k2krnm	580	4	-	-	HYPH
cord-022353-q2k2krnm	580	5	tissue	tissue	NN
cord-022353-q2k2krnm	580	6	.	.	.
cord-022353-q2k2krnm	581	1	In	in	IN
cord-022353-q2k2krnm	581	2	mouse	mouse	NN
cord-022353-q2k2krnm	581	3	MCP	MCP	NNP
cord-022353-q2k2krnm	581	4	is	be	VBZ
cord-022353-q2k2krnm	581	5	only	only	RB
cord-022353-q2k2krnm	581	6	expressed	express	VBN
cord-022353-q2k2krnm	581	7	in	in	IN
cord-022353-q2k2krnm	581	8	the	the	DT
cord-022353-q2k2krnm	581	9	testis	testis	NN
cord-022353-q2k2krnm	581	10	.	.	.
cord-022353-q2k2krnm	582	1	Complement	complement	JJ
cord-022353-q2k2krnm	582	2	receptors	receptor	NNS
cord-022353-q2k2krnm	582	3	1	1	CD
cord-022353-q2k2krnm	582	4	and	and	CC
cord-022353-q2k2krnm	582	5	2	2	CD
cord-022353-q2k2krnm	582	6	are	be	VBP
cord-022353-q2k2krnm	582	7	encoded	encode	VBN
cord-022353-q2k2krnm	582	8	by	by	IN
cord-022353-q2k2krnm	582	9	separategenes	separategene	NNS
cord-022353-q2k2krnm	582	10	in	in	IN
cord-022353-q2k2krnm	582	11	humans	human	NNS
cord-022353-q2k2krnm	582	12	but	but	CC
cord-022353-q2k2krnm	582	13	are	be	VBP
cord-022353-q2k2krnm	582	14	produced	produce	VBN
cord-022353-q2k2krnm	582	15	by	by	IN
cord-022353-q2k2krnm	582	16	alternative	alternative	JJ
cord-022353-q2k2krnm	582	17	splicing	splicing	NN
cord-022353-q2k2krnm	582	18	of	of	IN
cord-022353-q2k2krnm	582	19	a	a	DT
cord-022353-q2k2krnm	582	20	single	single	JJ
cord-022353-q2k2krnm	582	21	gene	gene	NN
cord-022353-q2k2krnm	582	22	in	in	IN
cord-022353-q2k2krnm	582	23	mouse	mouse	NN
cord-022353-q2k2krnm	582	24	.	.	.
cord-022353-q2k2krnm	583	1	Mice	mouse	NNS
cord-022353-q2k2krnm	583	2	have	have	VBP
cord-022353-q2k2krnm	583	3	a	a	DT
cord-022353-q2k2krnm	583	4	complement	complement	JJ
cord-022353-q2k2krnm	583	5	receptor	receptor	NN
cord-022353-q2k2krnm	583	6	1	1	CD
cord-022353-q2k2krnm	583	7	(	(	-LRB-
cord-022353-q2k2krnm	583	8	CR-1	CR-1	NNP
cord-022353-q2k2krnm	583	9	)	)	-RRB-
cord-022353-q2k2krnm	583	10	related	relate	VBN
cord-022353-q2k2krnm	583	11	gene	gene	NN
cord-022353-q2k2krnm	583	12	/	/	SYM
cord-022353-q2k2krnm	583	13	protein	protein	NN
cord-022353-q2k2krnm	583	14	Y	Y	NNP
cord-022353-q2k2krnm	583	15	(	(	-LRB-
cord-022353-q2k2krnm	583	16	Crry	Crry	NNP
cord-022353-q2k2krnm	583	17	)	)	-RRB-
cord-022353-q2k2krnm	583	18	not	not	RB
cord-022353-q2k2krnm	583	19	found	find	VBN
cord-022353-q2k2krnm	583	20	in	in	IN
cord-022353-q2k2krnm	583	21	humans	human	NNS
cord-022353-q2k2krnm	583	22	,	,	,
cord-022353-q2k2krnm	583	23	which	which	WDT
cord-022353-q2k2krnm	583	24	is	be	VBZ
cord-022353-q2k2krnm	583	25	a	a	DT
cord-022353-q2k2krnm	583	26	membrane	membrane	NN
cord-022353-q2k2krnm	583	27	-	-	HYPH
cord-022353-q2k2krnm	583	28	anchored	anchor	VBN
cord-022353-q2k2krnm	583	29	C3	c3	NN
cord-022353-q2k2krnm	583	30	inhibitor	inhibitor	NN
cord-022353-q2k2krnm	583	31	.	.	.
cord-022353-q2k2krnm	584	1	It	-PRON-	PRP
cord-022353-q2k2krnm	584	2	is	be	VBZ
cord-022353-q2k2krnm	584	3	the	the	DT
cord-022353-q2k2krnm	584	4	major	major	JJ
cord-022353-q2k2krnm	584	5	regulator	regulator	NN
cord-022353-q2k2krnm	584	6	of	of	IN
cord-022353-q2k2krnm	584	7	C3	C3	NNP
cord-022353-q2k2krnm	584	8	in	in	IN
cord-022353-q2k2krnm	584	9	mouse	mouse	NN
cord-022353-q2k2krnm	584	10	kidney	kidney	NN
cord-022353-q2k2krnm	584	11	and	and	CC
cord-022353-q2k2krnm	584	12	has	have	VBZ
cord-022353-q2k2krnm	584	13	some	some	DT
cord-022353-q2k2krnm	584	14	of	of	IN
cord-022353-q2k2krnm	584	15	the	the	DT
cord-022353-q2k2krnm	584	16	functions	function	NNS
cord-022353-q2k2krnm	584	17	as	as	IN
cord-022353-q2k2krnm	584	18	MCP	MCP	NNP
cord-022353-q2k2krnm	584	19	and	and	CC
cord-022353-q2k2krnm	584	20	CR1	CR1	NNP
cord-022353-q2k2krnm	584	21	in	in	IN
cord-022353-q2k2krnm	584	22	humans	human	NNS
cord-022353-q2k2krnm	584	23	.	.	.
cord-022353-q2k2krnm	585	1	Crry	Crry	NNP
cord-022353-q2k2krnm	585	2	has	have	VBZ
cord-022353-q2k2krnm	585	3	DAF	DAF	NNP
cord-022353-q2k2krnm	585	4	activity	activity	NN
cord-022353-q2k2krnm	585	5	and	and	CC
cord-022353-q2k2krnm	585	6	serves	serve	VBZ
cord-022353-q2k2krnm	585	7	as	as	IN
cord-022353-q2k2krnm	585	8	a	a	DT
cord-022353-q2k2krnm	585	9	cofactor	cofactor	NN
cord-022353-q2k2krnm	585	10	for	for	IN
cord-022353-q2k2krnm	585	11	factor	factor	NN
cord-022353-q2k2krnm	585	12	I	-PRON-	PRP
cord-022353-q2k2krnm	585	13	(	(	-LRB-
cord-022353-q2k2krnm	585	14	which	which	WDT
cord-022353-q2k2krnm	585	15	enzymatically	enzymatically	RB
cord-022353-q2k2krnm	585	16	cleaves	cleave	VBZ
cord-022353-q2k2krnm	585	17	C3b	C3b	NNP
cord-022353-q2k2krnm	585	18	)	)	-RRB-
cord-022353-q2k2krnm	585	19	.	.	.
cord-022353-q2k2krnm	586	1	The	the	DT
cord-022353-q2k2krnm	586	2	mouse	mouse	NN
cord-022353-q2k2krnm	586	3	has	have	VBZ
cord-022353-q2k2krnm	586	4	been	be	VBN
cord-022353-q2k2krnm	586	5	widely	widely	RB
cord-022353-q2k2krnm	586	6	used	use	VBN
cord-022353-q2k2krnm	586	7	in	in	IN
cord-022353-q2k2krnm	586	8	studies	study	NNS
cord-022353-q2k2krnm	586	9	on	on	IN
cord-022353-q2k2krnm	586	10	the	the	DT
cord-022353-q2k2krnm	586	11	biosynthesis	biosynthesis	NN
cord-022353-q2k2krnm	586	12	and	and	CC
cord-022353-q2k2krnm	586	13	molecular	molecular	JJ
cord-022353-q2k2krnm	586	14	biology	biology	NN
cord-022353-q2k2krnm	586	15	of	of	IN
cord-022353-q2k2krnm	586	16	individual	individual	JJ
cord-022353-q2k2krnm	586	17	components	component	NNS
cord-022353-q2k2krnm	586	18	of	of	IN
cord-022353-q2k2krnm	586	19	complement	complement	NN
cord-022353-q2k2krnm	586	20	.	.	.
cord-022353-q2k2krnm	587	1	The	the	DT
cord-022353-q2k2krnm	587	2	genes	gene	NNS
cord-022353-q2k2krnm	587	3	encoding	encode	VBG
cord-022353-q2k2krnm	587	4	39	39	CD
cord-022353-q2k2krnm	587	5	components	component	NNS
cord-022353-q2k2krnm	587	6	,	,	,
cord-022353-q2k2krnm	587	7	subcomponents	subcomponent	NNS
cord-022353-q2k2krnm	587	8	,	,	,
cord-022353-q2k2krnm	587	9	receptors	receptor	NNS
cord-022353-q2k2krnm	587	10	,	,	,
cord-022353-q2k2krnm	587	11	and	and	CC
cord-022353-q2k2krnm	587	12	inhibitors	inhibitor	NNS
cord-022353-q2k2krnm	587	13	have	have	VBP
cord-022353-q2k2krnm	587	14	been	be	VBN
cord-022353-q2k2krnm	587	15	identified	identify	VBN
cord-022353-q2k2krnm	587	16	in	in	IN
cord-022353-q2k2krnm	587	17	mice	mouse	NNS
cord-022353-q2k2krnm	587	18	.	.	.
cord-022353-q2k2krnm	588	1	The	the	DT
cord-022353-q2k2krnm	588	2	complement	complement	JJ
cord-022353-q2k2krnm	588	3	components	component	NNS
cord-022353-q2k2krnm	588	4	may	may	MD
cord-022353-q2k2krnm	588	5	be	be	VB
cord-022353-q2k2krnm	588	6	quantified	quantify	VBN
cord-022353-q2k2krnm	588	7	by	by	IN
cord-022353-q2k2krnm	588	8	assays	assay	NNS
cord-022353-q2k2krnm	588	9	designed	design	VBN
cord-022353-q2k2krnm	588	10	to	to	TO
cord-022353-q2k2krnm	588	11	measure	measure	VB
cord-022353-q2k2krnm	588	12	the	the	DT
cord-022353-q2k2krnm	588	13	functional	functional	JJ
cord-022353-q2k2krnm	588	14	properties	property	NNS
cord-022353-q2k2krnm	588	15	of	of	IN
cord-022353-q2k2krnm	588	16	these	these	DT
cord-022353-q2k2krnm	588	17	proteins	protein	NNS
cord-022353-q2k2krnm	588	18	or	or	CC
cord-022353-q2k2krnm	588	19	their	-PRON-	PRP$
cord-022353-q2k2krnm	588	20	antigenic	antigenic	JJ
cord-022353-q2k2krnm	588	21	properties	property	NNS
cord-022353-q2k2krnm	588	22	.	.	.
cord-022353-q2k2krnm	589	1	Tests	test	NNS
cord-022353-q2k2krnm	589	2	designed	design	VBN
cord-022353-q2k2krnm	589	3	to	to	TO
cord-022353-q2k2krnm	589	4	measure	measure	VB
cord-022353-q2k2krnm	589	5	antigenic	antigenic	JJ
cord-022353-q2k2krnm	589	6	properties	property	NNS
cord-022353-q2k2krnm	589	7	of	of	IN
cord-022353-q2k2krnm	589	8	complement	complement	NN
cord-022353-q2k2krnm	589	9	are	be	VBP
cord-022353-q2k2krnm	589	10	generally	generally	RB
cord-022353-q2k2krnm	589	11	simpler	simple	JJR
cord-022353-q2k2krnm	589	12	,	,	,
cord-022353-q2k2krnm	589	13	less	less	RBR
cord-022353-q2k2krnm	589	14	subject	subject	JJ
cord-022353-q2k2krnm	589	15	to	to	IN
cord-022353-q2k2krnm	589	16	error	error	NN
cord-022353-q2k2krnm	589	17	,	,	,
cord-022353-q2k2krnm	589	18	and	and	CC
cord-022353-q2k2krnm	589	19	less	less	RBR
cord-022353-q2k2krnm	589	20	expensive	expensive	JJ
cord-022353-q2k2krnm	589	21	;	;	:
cord-022353-q2k2krnm	589	22	however	however	RB
cord-022353-q2k2krnm	589	23	,	,	,
cord-022353-q2k2krnm	589	24	they	-PRON-	PRP
cord-022353-q2k2krnm	589	25	have	have	VBP
cord-022353-q2k2krnm	589	26	the	the	DT
cord-022353-q2k2krnm	589	27	disadvantage	disadvantage	NN
cord-022353-q2k2krnm	589	28	of	of	IN
cord-022353-q2k2krnm	589	29	measuring	measure	VBG
cord-022353-q2k2krnm	589	30	both	both	CC
cord-022353-q2k2krnm	589	31	active	active	JJ
cord-022353-q2k2krnm	589	32	and	and	CC
cord-022353-q2k2krnm	589	33	inactive	inactive	JJ
cord-022353-q2k2krnm	589	34	forms	form	NNS
cord-022353-q2k2krnm	589	35	of	of	IN
cord-022353-q2k2krnm	589	36	their	-PRON-	PRP$
cord-022353-q2k2krnm	589	37	proteins	protein	NNS
cord-022353-q2k2krnm	589	38	and	and	CC
cord-022353-q2k2krnm	589	39	therefore	therefore	RB
cord-022353-q2k2krnm	589	40	may	may	MD
cord-022353-q2k2krnm	589	41	not	not	RB
cord-022353-q2k2krnm	589	42	correlate	correlate	VB
cord-022353-q2k2krnm	589	43	well	well	RB
cord-022353-q2k2krnm	589	44	with	with	IN
cord-022353-q2k2krnm	589	45	functionally	functionally	RB
cord-022353-q2k2krnm	589	46	active	active	JJ
cord-022353-q2k2krnm	589	47	protein	protein	NN
cord-022353-q2k2krnm	589	48	.	.	.
cord-022353-q2k2krnm	590	1	Functional	functional	JJ
cord-022353-q2k2krnm	590	2	assays	assay	NNS
cord-022353-q2k2krnm	590	3	measure	measure	VBP
cord-022353-q2k2krnm	590	4	the	the	DT
cord-022353-q2k2krnm	590	5	ability	ability	NN
cord-022353-q2k2krnm	590	6	of	of	IN
cord-022353-q2k2krnm	590	7	the	the	DT
cord-022353-q2k2krnm	590	8	entire	entire	JJ
cord-022353-q2k2krnm	590	9	classical	classical	JJ
cord-022353-q2k2krnm	590	10	or	or	CC
cord-022353-q2k2krnm	590	11	alternative	alternative	JJ
cord-022353-q2k2krnm	590	12	pathway	pathway	NN
cord-022353-q2k2krnm	590	13	,	,	,
cord-022353-q2k2krnm	590	14	or	or	CC
cord-022353-q2k2krnm	590	15	individual	individual	JJ
cord-022353-q2k2krnm	590	16	components	component	NNS
cord-022353-q2k2krnm	590	17	of	of	IN
cord-022353-q2k2krnm	590	18	pathways	pathway	NNS
cord-022353-q2k2krnm	590	19	to	to	TO
cord-022353-q2k2krnm	590	20	lyse	lyse	VB
cord-022353-q2k2krnm	590	21	(	(	-LRB-
cord-022353-q2k2krnm	590	22	hemolyze	hemolyze	NNP
cord-022353-q2k2krnm	590	23	)	)	-RRB-
cord-022353-q2k2krnm	590	24	antibody	antibody	NN
cord-022353-q2k2krnm	590	25	-	-	HYPH
cord-022353-q2k2krnm	590	26	coated	coated	JJ
cord-022353-q2k2krnm	590	27	(	(	-LRB-
cord-022353-q2k2krnm	590	28	sensitized	sensitized	JJ
cord-022353-q2k2krnm	590	29	)	)	-RRB-
cord-022353-q2k2krnm	590	30	or	or	CC
cord-022353-q2k2krnm	590	31	noncoated	noncoate	VBN
cord-022353-q2k2krnm	590	32	(	(	-LRB-
cord-022353-q2k2krnm	590	33	for	for	IN
cord-022353-q2k2krnm	590	34	the	the	DT
cord-022353-q2k2krnm	590	35	alternative	alternative	JJ
cord-022353-q2k2krnm	590	36	pathway	pathway	NN
cord-022353-q2k2krnm	590	37	)	)	-RRB-
cord-022353-q2k2krnm	590	38	red	red	JJ
cord-022353-q2k2krnm	590	39	cells	cell	NNS
cord-022353-q2k2krnm	590	40	in	in	IN
cord-022353-q2k2krnm	590	41	suspension	suspension	NN
cord-022353-q2k2krnm	590	42	or	or	CC
cord-022353-q2k2krnm	590	43	in	in	IN
cord-022353-q2k2krnm	590	44	agarose	agarose	JJ
cord-022353-q2k2krnm	590	45	gel	gel	NN
cord-022353-q2k2krnm	590	46	.	.	.
cord-022353-q2k2krnm	591	1	These	these	DT
cord-022353-q2k2krnm	591	2	assays	assay	NNS
cord-022353-q2k2krnm	591	3	are	be	VBP
cord-022353-q2k2krnm	591	4	precise	precise	JJ
cord-022353-q2k2krnm	591	5	and	and	CC
cord-022353-q2k2krnm	591	6	sensitive	sensitive	JJ
cord-022353-q2k2krnm	592	1	(	(	-LRB-
cord-022353-q2k2krnm	592	2	Quimby	Quimby	NNP
cord-022353-q2k2krnm	592	3	1999a	1999a	CD
cord-022353-q2k2krnm	592	4	)	)	-RRB-
cord-022353-q2k2krnm	592	5	.	.	.
cord-022353-q2k2krnm	593	1	Antigenic	antigenic	JJ
cord-022353-q2k2krnm	593	2	assays	assay	NNS
cord-022353-q2k2krnm	593	3	include	include	VBP
cord-022353-q2k2krnm	593	4	radial	radial	JJ
cord-022353-q2k2krnm	593	5	immunodiffusion	immunodiffusion	NN
cord-022353-q2k2krnm	593	6	,	,	,
cord-022353-q2k2krnm	593	7	electroimmunodiffusion	electroimmunodiffusion	NN
cord-022353-q2k2krnm	593	8	(	(	-LRB-
cord-022353-q2k2krnm	593	9	rocket	rocket	NN
cord-022353-q2k2krnm	593	10	electrophoresis	electrophoresis	NN
cord-022353-q2k2krnm	593	11	)	)	-RRB-
cord-022353-q2k2krnm	593	12	,	,	,
cord-022353-q2k2krnm	593	13	automated	automate	VBN
cord-022353-q2k2krnm	593	14	immunoprecipitation	immunoprecipitation	NN
cord-022353-q2k2krnm	593	15	,	,	,
cord-022353-q2k2krnm	593	16	crossed	cross	VBD
cord-022353-q2k2krnm	593	17	immunoelectrophoresis	immunoelectrophoresis	NN
cord-022353-q2k2krnm	593	18	,	,	,
cord-022353-q2k2krnm	593	19	and	and	CC
cord-022353-q2k2krnm	593	20	more	more	RBR
cord-022353-q2k2krnm	593	21	recently	recently	RB
cord-022353-q2k2krnm	593	22	ELISA	ELISA	NNP
cord-022353-q2k2krnm	593	23	(	(	-LRB-
cord-022353-q2k2krnm	593	24	Quimby	Quimby	NNP
cord-022353-q2k2krnm	593	25	1999a	1999a	CD
cord-022353-q2k2krnm	593	26	)	)	-RRB-
cord-022353-q2k2krnm	593	27	.	.	.
cord-022353-q2k2krnm	594	1	ELISA	ELISA	NNP
cord-022353-q2k2krnm	594	2	kits	kit	NNS
cord-022353-q2k2krnm	594	3	are	be	VBP
cord-022353-q2k2krnm	594	4	commercially	commercially	RB
cord-022353-q2k2krnm	594	5	available	available	JJ
cord-022353-q2k2krnm	594	6	for	for	IN
cord-022353-q2k2krnm	594	7	quantifying	quantify	VBG
cord-022353-q2k2krnm	594	8	murine	murine	JJ
cord-022353-q2k2krnm	594	9	C	c	NN
cord-022353-q2k2krnm	594	10	lq	lq	NN
cord-022353-q2k2krnm	594	11	,	,	,
cord-022353-q2k2krnm	594	12	C3	C3	NNP
cord-022353-q2k2krnm	594	13	,	,	,
cord-022353-q2k2krnm	594	14	C4	C4	NNP
cord-022353-q2k2krnm	594	15	,	,	,
cord-022353-q2k2krnm	594	16	C3a	C3a	NNP
cord-022353-q2k2krnm	594	17	(	(	-LRB-
cord-022353-q2k2krnm	594	18	desArg	desArg	NNP
cord-022353-q2k2krnm	594	19	)	)	-RRB-
cord-022353-q2k2krnm	594	20	,	,	,
cord-022353-q2k2krnm	594	21	and	and	CC
cord-022353-q2k2krnm	594	22	C3a	C3a	NNP
cord-022353-q2k2krnm	594	23	.	.	.
cord-022353-q2k2krnm	595	1	In	in	IN
cord-022353-q2k2krnm	595	2	addition	addition	NN
cord-022353-q2k2krnm	595	3	antibodies	antibody	NNS
cord-022353-q2k2krnm	595	4	are	be	VBP
cord-022353-q2k2krnm	595	5	commercially	commercially	RB
cord-022353-q2k2krnm	595	6	available	available	JJ
cord-022353-q2k2krnm	595	7	for	for	IN
cord-022353-q2k2krnm	595	8	these	these	DT
cord-022353-q2k2krnm	595	9	as	as	RB
cord-022353-q2k2krnm	595	10	well	well	RB
cord-022353-q2k2krnm	595	11	as	as	IN
cord-022353-q2k2krnm	595	12	murine	murine	JJ
cord-022353-q2k2krnm	595	13	C4a	C4a	NNP
cord-022353-q2k2krnm	595	14	,	,	,
cord-022353-q2k2krnm	595	15	C4d	C4d	NNP
cord-022353-q2k2krnm	595	16	,	,	,
cord-022353-q2k2krnm	595	17	C5	C5	NNP
cord-022353-q2k2krnm	595	18	,	,	,
cord-022353-q2k2krnm	595	19	and	and	CC
cord-022353-q2k2krnm	595	20	C6	c6	NN
cord-022353-q2k2krnm	595	21	.	.	.
cord-022353-q2k2krnm	596	1	Complement	complement	JJ
cord-022353-q2k2krnm	596	2	components	component	NNS
cord-022353-q2k2krnm	596	3	C2	C2	NNP
cord-022353-q2k2krnm	596	4	,	,	,
cord-022353-q2k2krnm	596	5	C5	C5	NNP
cord-022353-q2k2krnm	596	6	,	,	,
cord-022353-q2k2krnm	596	7	C6	C6	NNP
cord-022353-q2k2krnm	596	8	,	,	,
cord-022353-q2k2krnm	596	9	C7	C7	NNP
cord-022353-q2k2krnm	596	10	,	,	,
cord-022353-q2k2krnm	596	11	and	and	CC
cord-022353-q2k2krnm	596	12	Factor	Factor	NNP
cord-022353-q2k2krnm	596	13	B	B	NNP
cord-022353-q2k2krnm	596	14	may	may	MD
cord-022353-q2k2krnm	596	15	be	be	VB
cord-022353-q2k2krnm	596	16	quantified	quantify	VBN
cord-022353-q2k2krnm	596	17	using	use	VBG
cord-022353-q2k2krnm	596	18	functional	functional	JJ
cord-022353-q2k2krnm	596	19	assays	assay	NNS
cord-022353-q2k2krnm	596	20	(	(	-LRB-
cord-022353-q2k2krnm	596	21	Quimby	Quimby	NNP
cord-022353-q2k2krnm	596	22	1999a	1999a	CD
cord-022353-q2k2krnm	596	23	)	)	-RRB-
cord-022353-q2k2krnm	596	24	.	.	.
cord-022353-q2k2krnm	597	1	Membrane	membrane	NN
cord-022353-q2k2krnm	597	2	-	-	HYPH
cord-022353-q2k2krnm	597	3	bound	bind	VBN
cord-022353-q2k2krnm	597	4	complement	complement	NN
cord-022353-q2k2krnm	597	5	regulators	regulator	NNS
cord-022353-q2k2krnm	597	6	,	,	,
cord-022353-q2k2krnm	597	7	Crry	Crry	NNP
cord-022353-q2k2krnm	597	8	,	,	,
cord-022353-q2k2krnm	597	9	CD59	CD59	NNP
cord-022353-q2k2krnm	597	10	,	,	,
cord-022353-q2k2krnm	597	11	and	and	CC
cord-022353-q2k2krnm	597	12	DAF	DAF	NNP
cord-022353-q2k2krnm	597	13	,	,	,
cord-022353-q2k2krnm	597	14	can	can	MD
cord-022353-q2k2krnm	597	15	all	all	DT
cord-022353-q2k2krnm	597	16	be	be	VB
cord-022353-q2k2krnm	597	17	detected	detect	VBN
cord-022353-q2k2krnm	597	18	using	use	VBG
cord-022353-q2k2krnm	597	19	previously	previously	RB
cord-022353-q2k2krnm	597	20	published	publish	VBN
cord-022353-q2k2krnm	597	21	antibodies	antibody	NNS
cord-022353-q2k2krnm	597	22	(	(	-LRB-
cord-022353-q2k2krnm	597	23	Lin	Lin	NNP
cord-022353-q2k2krnm	597	24	et	et	NNP
cord-022353-q2k2krnm	597	25	al	al	NNP
cord-022353-q2k2krnm	597	26	.	.	.
cord-022353-q2k2krnm	598	1	2001	2001	CD
cord-022353-q2k2krnm	598	2	(	(	-LRB-
cord-022353-q2k2krnm	598	3	Lin	Lin	NNP
cord-022353-q2k2krnm	598	4	et	et	NNP
cord-022353-q2k2krnm	598	5	al	al	NNP
cord-022353-q2k2krnm	598	6	.	.	NNP
cord-022353-q2k2krnm	598	7	,	,	,
cord-022353-q2k2krnm	598	8	2002	2002	CD
cord-022353-q2k2krnm	598	9	.	.	.
cord-022353-q2k2krnm	599	1	The	the	DT
cord-022353-q2k2krnm	599	2	principle	principle	JJ
cord-022353-q2k2krnm	599	3	mediator	mediator	NN
cord-022353-q2k2krnm	599	4	of	of	IN
cord-022353-q2k2krnm	599	5	the	the	DT
cord-022353-q2k2krnm	599	6	lectin	lectin	NN
cord-022353-q2k2krnm	599	7	activation	activation	NN
cord-022353-q2k2krnm	599	8	pathway	pathway	NN
cord-022353-q2k2krnm	599	9	is	be	VBZ
cord-022353-q2k2krnm	599	10	mannose	mannose	NN
cord-022353-q2k2krnm	599	11	-	-	HYPH
cord-022353-q2k2krnm	599	12	binding	bind	VBG
cord-022353-q2k2krnm	599	13	lectin	lectin	NN
cord-022353-q2k2krnm	599	14	(	(	-LRB-
cord-022353-q2k2krnm	599	15	MBL	MBL	NNP
cord-022353-q2k2krnm	599	16	)	)	-RRB-
cord-022353-q2k2krnm	599	17	.	.	.
cord-022353-q2k2krnm	600	1	After	after	IN
cord-022353-q2k2krnm	600	2	binding	bind	VBG
cord-022353-q2k2krnm	600	3	to	to	IN
cord-022353-q2k2krnm	600	4	mannose	mannose	NN
cord-022353-q2k2krnm	600	5	residues	residue	NNS
cord-022353-q2k2krnm	600	6	on	on	IN
cord-022353-q2k2krnm	600	7	the	the	DT
cord-022353-q2k2krnm	600	8	surface	surface	NN
cord-022353-q2k2krnm	600	9	of	of	IN
cord-022353-q2k2krnm	600	10	microorganisms	microorganism	NNS
cord-022353-q2k2krnm	600	11	,	,	,
cord-022353-q2k2krnm	600	12	two	two	CD
cord-022353-q2k2krnm	600	13	MBL	MBL	NNP
cord-022353-q2k2krnm	600	14	-	-	HYPH
cord-022353-q2k2krnm	600	15	associated	associate	VBN
cord-022353-q2k2krnm	600	16	serine	serine	NN
cord-022353-q2k2krnm	600	17	proteases	protease	NNS
cord-022353-q2k2krnm	600	18	(	(	-LRB-
cord-022353-q2k2krnm	600	19	MASPs	masp	NNS
cord-022353-q2k2krnm	600	20	)	)	-RRB-
cord-022353-q2k2krnm	600	21	,	,	,
cord-022353-q2k2krnm	600	22	MASP-1	MASP-1	NNP
cord-022353-q2k2krnm	600	23	and	and	CC
cord-022353-q2k2krnm	600	24	MASP-2	MASP-2	NNP
cord-022353-q2k2krnm	600	25	,	,	,
cord-022353-q2k2krnm	600	26	bind	bind	VB
cord-022353-q2k2krnm	600	27	to	to	IN
cord-022353-q2k2krnm	600	28	MBL	MBL	NNP
cord-022353-q2k2krnm	600	29	.	.	.
cord-022353-q2k2krnm	601	1	This	this	DT
cord-022353-q2k2krnm	601	2	complex	complex	JJ
cord-022353-q2k2krnm	601	3	causes	cause	VBZ
cord-022353-q2k2krnm	601	4	cleavage	cleavage	NN
cord-022353-q2k2krnm	601	5	and	and	CC
cord-022353-q2k2krnm	601	6	activation	activation	NN
cord-022353-q2k2krnm	601	7	of	of	IN
cord-022353-q2k2krnm	601	8	C4	C4	NNP
cord-022353-q2k2krnm	601	9	and	and	CC
cord-022353-q2k2krnm	601	10	C2	C2	NNP
cord-022353-q2k2krnm	601	11	(	(	-LRB-
cord-022353-q2k2krnm	601	12	MASP1	masp1	NN
cord-022353-q2k2krnm	601	13	and	and	CC
cord-022353-q2k2krnm	601	14	2	2	CD
cord-022353-q2k2krnm	601	15	mimic	mimic	VBP
cord-022353-q2k2krnm	601	16	the	the	DT
cord-022353-q2k2krnm	601	17	activities	activity	NNS
cord-022353-q2k2krnm	601	18	of	of	IN
cord-022353-q2k2krnm	601	19	C14	C14	NNP
cord-022353-q2k2krnm	601	20	and	and	CC
cord-022353-q2k2krnm	601	21	Cls	Cls	NNP
cord-022353-q2k2krnm	601	22	)	)	-RRB-
cord-022353-q2k2krnm	601	23	.	.	.
cord-022353-q2k2krnm	602	1	Commercially	commercially	RB
cord-022353-q2k2krnm	602	2	available	available	JJ
cord-022353-q2k2krnm	602	3	ELISA	ELISA	NNP
cord-022353-q2k2krnm	602	4	kits	kit	NNS
cord-022353-q2k2krnm	602	5	are	be	VBP
cord-022353-q2k2krnm	602	6	available	available	JJ
cord-022353-q2k2krnm	602	7	for	for	IN
cord-022353-q2k2krnm	602	8	murine	murine	JJ
cord-022353-q2k2krnm	602	9	MBL	MBL	NNP
cord-022353-q2k2krnm	602	10	-	-	HYPH
cord-022353-q2k2krnm	602	11	A	A	NNP
cord-022353-q2k2krnm	602	12	and	and	CC
cord-022353-q2k2krnm	602	13	MBL	MBL	NNP
cord-022353-q2k2krnm	602	14	-	-	HYPH
cord-022353-q2k2krnm	602	15	C	C	NNP
cord-022353-q2k2krnm	602	16	quantitation	quantitation	NN
cord-022353-q2k2krnm	602	17	.	.	.
cord-022353-q2k2krnm	603	1	Other	other	JJ
cord-022353-q2k2krnm	603	2	activators	activator	NNS
cord-022353-q2k2krnm	603	3	of	of	IN
cord-022353-q2k2krnm	603	4	complement	complement	NN
cord-022353-q2k2krnm	603	5	include	include	VBP
cord-022353-q2k2krnm	603	6	members	member	NNS
cord-022353-q2k2krnm	603	7	of	of	IN
cord-022353-q2k2krnm	603	8	the	the	DT
cord-022353-q2k2krnm	603	9	pentraxin	pentraxin	NNP
cord-022353-q2k2krnm	603	10	family	family	NN
cord-022353-q2k2krnm	603	11	.	.	.
cord-022353-q2k2krnm	604	1	In	in	IN
cord-022353-q2k2krnm	604	2	mice	mouse	NNS
cord-022353-q2k2krnm	604	3	this	this	DT
cord-022353-q2k2krnm	604	4	may	may	MD
cord-022353-q2k2krnm	604	5	include	include	VB
cord-022353-q2k2krnm	604	6	CRP	CRP	NNP
cord-022353-q2k2krnm	604	7	or	or	CC
cord-022353-q2k2krnm	604	8	SAP	SAP	NNP
cord-022353-q2k2krnm	604	9	,	,	,
cord-022353-q2k2krnm	604	10	although	although	IN
cord-022353-q2k2krnm	604	11	the	the	DT
cord-022353-q2k2krnm	604	12	concentration	concentration	NN
cord-022353-q2k2krnm	604	13	of	of	IN
cord-022353-q2k2krnm	604	14	CRP	CRP	NNP
cord-022353-q2k2krnm	604	15	in	in	IN
cord-022353-q2k2krnm	604	16	normal	normal	JJ
cord-022353-q2k2krnm	604	17	mice	mice	NN
cord-022353-q2k2krnm	604	18	is	be	VBZ
cord-022353-q2k2krnm	604	19	very	very	RB
cord-022353-q2k2krnm	604	20	low	low	JJ
cord-022353-q2k2krnm	604	21	.	.	.
cord-022353-q2k2krnm	605	1	Immunologic	immunologic	JJ
cord-022353-q2k2krnm	605	2	reagents	reagent	NNS
cord-022353-q2k2krnm	605	3	are	be	VBP
cord-022353-q2k2krnm	605	4	available	available	JJ
cord-022353-q2k2krnm	605	5	to	to	TO
cord-022353-q2k2krnm	605	6	quantify	quantify	VB
cord-022353-q2k2krnm	605	7	both	both	DT
cord-022353-q2k2krnm	605	8	pentraxins	pentraxin	NNS
cord-022353-q2k2krnm	605	9	in	in	IN
cord-022353-q2k2krnm	605	10	mice	mouse	NNS
cord-022353-q2k2krnm	605	11	(	(	-LRB-
cord-022353-q2k2krnm	605	12	Gentry	Gentry	NNP
cord-022353-q2k2krnm	605	13	1999	1999	CD
cord-022353-q2k2krnm	605	14	;	;	:
cord-022353-q2k2krnm	605	15	Quimby	Quimby	NNP
cord-022353-q2k2krnm	605	16	1999b	1999b	CD
cord-022353-q2k2krnm	605	17	)	)	-RRB-
cord-022353-q2k2krnm	605	18	.	.	.
cord-022353-q2k2krnm	606	1	Circulating	circulate	VBG
cord-022353-q2k2krnm	606	2	immune	immune	JJ
cord-022353-q2k2krnm	606	3	complexes	complex	NNS
cord-022353-q2k2krnm	606	4	(	(	-LRB-
cord-022353-q2k2krnm	606	5	CIC	CIC	NNP
cord-022353-q2k2krnm	606	6	)	)	-RRB-
cord-022353-q2k2krnm	606	7	are	be	VBP
cord-022353-q2k2krnm	606	8	multimolecular	multimolecular	JJ
cord-022353-q2k2krnm	606	9	substances	substance	NNS
cord-022353-q2k2krnm	606	10	composed	compose	VBN
cord-022353-q2k2krnm	606	11	of	of	IN
cord-022353-q2k2krnm	606	12	antigen	antigen	NN
cord-022353-q2k2krnm	606	13	,	,	,
cord-022353-q2k2krnm	606	14	antibody	antibody	NN
cord-022353-q2k2krnm	606	15	,	,	,
cord-022353-q2k2krnm	606	16	and	and	CC
cord-022353-q2k2krnm	606	17	activated	activate	VBN
cord-022353-q2k2krnm	606	18	complement	complement	JJ
cord-022353-q2k2krnm	606	19	components	component	NNS
cord-022353-q2k2krnm	606	20	.	.	.
cord-022353-q2k2krnm	607	1	In	in	IN
cord-022353-q2k2krnm	607	2	mice	mouse	NNS
cord-022353-q2k2krnm	607	3	,	,	,
cord-022353-q2k2krnm	607	4	IgM	IgM	NNP
cord-022353-q2k2krnm	607	5	,	,	,
cord-022353-q2k2krnm	607	6	IgG1	IgG1	NNP
cord-022353-q2k2krnm	607	7	,	,	,
cord-022353-q2k2krnm	607	8	IgG2a	IgG2a	NNP
cord-022353-q2k2krnm	607	9	,	,	,
cord-022353-q2k2krnm	607	10	and	and	CC
cord-022353-q2k2krnm	607	11	IgG2b	IgG2b	NNS
cord-022353-q2k2krnm	607	12	have	have	VBP
cord-022353-q2k2krnm	607	13	complement	complement	JJ
cord-022353-q2k2krnm	607	14	activation	activation	NN
cord-022353-q2k2krnm	607	15	regions	region	NNS
cord-022353-q2k2krnm	607	16	.	.	.
cord-022353-q2k2krnm	608	1	Although	although	IN
cord-022353-q2k2krnm	608	2	CIC	CIC	NNP
cord-022353-q2k2krnm	608	3	may	may	MD
cord-022353-q2k2krnm	608	4	form	form	VB
cord-022353-q2k2krnm	608	5	following	follow	VBG
cord-022353-q2k2krnm	608	6	exposure	exposure	NN
cord-022353-q2k2krnm	608	7	to	to	IN
cord-022353-q2k2krnm	608	8	circulating	circulate	VBG
cord-022353-q2k2krnm	608	9	foreign	foreign	JJ
cord-022353-q2k2krnm	608	10	antigens	antigen	NNS
cord-022353-q2k2krnm	608	11	,	,	,
cord-022353-q2k2krnm	608	12	such	such	JJ
cord-022353-q2k2krnm	608	13	as	as	IN
cord-022353-q2k2krnm	608	14	those	those	DT
cord-022353-q2k2krnm	608	15	associated	associate	VBN
cord-022353-q2k2krnm	608	16	with	with	IN
cord-022353-q2k2krnm	608	17	microorganisms	microorganism	NNS
cord-022353-q2k2krnm	608	18	,	,	,
cord-022353-q2k2krnm	608	19	they	-PRON-	PRP
cord-022353-q2k2krnm	608	20	are	be	VBP
cord-022353-q2k2krnm	608	21	also	also	RB
cord-022353-q2k2krnm	608	22	common	common	JJ
cord-022353-q2k2krnm	608	23	manifestations	manifestation	NNS
cord-022353-q2k2krnm	608	24	of	of	IN
cord-022353-q2k2krnm	608	25	spontaneous	spontaneous	JJ
cord-022353-q2k2krnm	608	26	autoimmune	autoimmune	JJ
cord-022353-q2k2krnm	608	27	disease	disease	NN
cord-022353-q2k2krnm	608	28	such	such	JJ
cord-022353-q2k2krnm	608	29	as	as	IN
cord-022353-q2k2krnm	608	30	that	that	DT
cord-022353-q2k2krnm	608	31	seen	see	VBN
cord-022353-q2k2krnm	608	32	in	in	IN
cord-022353-q2k2krnm	608	33	(	(	-LRB-
cord-022353-q2k2krnm	608	34	NZB	NZB	NNP
cord-022353-q2k2krnm	608	35	X	X	NNP
cord-022353-q2k2krnm	608	36	NZW)F1	NZW)F1	NNP
cord-022353-q2k2krnm	608	37	,	,	,
cord-022353-q2k2krnm	608	38	MRL	MRL	NNP
cord-022353-q2k2krnm	608	39	/	/	SYM
cord-022353-q2k2krnm	608	40	Lpr	Lpr	NNP
cord-022353-q2k2krnm	608	41	,	,	,
cord-022353-q2k2krnm	608	42	BXSB	BXSB	NNP
cord-022353-q2k2krnm	608	43	,	,	,
cord-022353-q2k2krnm	608	44	and	and	CC
cord-022353-q2k2krnm	608	45	KRN	KRN	NNP
cord-022353-q2k2krnm	608	46	strains	strain	NNS
cord-022353-q2k2krnm	608	47	.	.	.
cord-022353-q2k2krnm	609	1	CIC	CIC	NNP
cord-022353-q2k2krnm	609	2	are	be	VBP
cord-022353-q2k2krnm	609	3	cleared	clear	VBN
cord-022353-q2k2krnm	609	4	from	from	IN
cord-022353-q2k2krnm	609	5	the	the	DT
cord-022353-q2k2krnm	609	6	circulation	circulation	NN
cord-022353-q2k2krnm	609	7	by	by	IN
cord-022353-q2k2krnm	609	8	both	both	CC
cord-022353-q2k2krnm	609	9	CR-1	CR-1	NNP
cord-022353-q2k2krnm	609	10	,	,	,
cord-022353-q2k2krnm	609	11	CR-2	CR-2	NNP
cord-022353-q2k2krnm	609	12	,	,	,
cord-022353-q2k2krnm	609	13	and	and	CC
cord-022353-q2k2krnm	609	14	FcR.	FcR.	NNP
cord-022353-q2k2krnm	609	15	Tissue	Tissue	NNP
cord-022353-q2k2krnm	609	16	deposition	deposition	NN
cord-022353-q2k2krnm	609	17	of	of	IN
cord-022353-q2k2krnm	609	18	immune	immune	JJ
cord-022353-q2k2krnm	609	19	complexes	complex	NNS
cord-022353-q2k2krnm	609	20	may	may	MD
cord-022353-q2k2krnm	609	21	lead	lead	VB
cord-022353-q2k2krnm	609	22	to	to	IN
cord-022353-q2k2krnm	609	23	vasculitis	vasculitis	NN
cord-022353-q2k2krnm	609	24	.	.	.
cord-022353-q2k2krnm	610	1	CIC	CIC	NNP
cord-022353-q2k2krnm	610	2	have	have	VBP
cord-022353-q2k2krnm	610	3	been	be	VBN
cord-022353-q2k2krnm	610	4	quantified	quantify	VBN
cord-022353-q2k2krnm	610	5	in	in	IN
cord-022353-q2k2krnm	610	6	mice	mouse	NNS
cord-022353-q2k2krnm	610	7	by	by	IN
cord-022353-q2k2krnm	610	8	capitalizing	capitalize	VBG
cord-022353-q2k2krnm	610	9	on	on	IN
cord-022353-q2k2krnm	610	10	their	-PRON-	PRP$
cord-022353-q2k2krnm	610	11	binding	binding	NN
cord-022353-q2k2krnm	610	12	to	to	IN
cord-022353-q2k2krnm	610	13	various	various	JJ
cord-022353-q2k2krnm	610	14	complement	complement	NN
cord-022353-q2k2krnm	610	15	receptors	receptor	NNS
cord-022353-q2k2krnm	610	16	,	,	,
cord-022353-q2k2krnm	610	17	by	by	IN
cord-022353-q2k2krnm	610	18	precipitation	precipitation	NN
cord-022353-q2k2krnm	610	19	of	of	IN
cord-022353-q2k2krnm	610	20	Clq	Clq	NNP
cord-022353-q2k2krnm	610	21	with	with	IN
cord-022353-q2k2krnm	610	22	polyethylene	polyethylene	NN
cord-022353-q2k2krnm	610	23	glycol	glycol	NN
cord-022353-q2k2krnm	610	24	,	,	,
cord-022353-q2k2krnm	610	25	or	or	CC
cord-022353-q2k2krnm	610	26	by	by	IN
cord-022353-q2k2krnm	610	27	immunoassay	immunoassay	NN
cord-022353-q2k2krnm	610	28	.	.	.
cord-022353-q2k2krnm	611	1	Commercially	commercially	RB
cord-022353-q2k2krnm	611	2	available	available	JJ
cord-022353-q2k2krnm	611	3	ELISA	ELISA	NNP
cord-022353-q2k2krnm	611	4	kits	kit	NNS
cord-022353-q2k2krnm	611	5	are	be	VBP
cord-022353-q2k2krnm	611	6	commonly	commonly	RB
cord-022353-q2k2krnm	611	7	employed	employ	VBN
cord-022353-q2k2krnm	611	8	today	today	NN
cord-022353-q2k2krnm	611	9	(	(	-LRB-
cord-022353-q2k2krnm	611	10	Quimby	Quimby	NNP
cord-022353-q2k2krnm	611	11	1999b	1999b	CD
cord-022353-q2k2krnm	611	12	)	)	-RRB-
cord-022353-q2k2krnm	611	13	.	.	.
cord-022353-q2k2krnm	612	1	More	More	JJR
cord-022353-q2k2krnm	612	2	than	than	IN
cord-022353-q2k2krnm	612	3	100	100	CD
cord-022353-q2k2krnm	612	4	inbred	inbred	JJ
cord-022353-q2k2krnm	612	5	strains	strain	NNS
cord-022353-q2k2krnm	612	6	or	or	CC
cord-022353-q2k2krnm	612	7	mutant	mutant	JJ
cord-022353-q2k2krnm	612	8	lines	line	NNS
cord-022353-q2k2krnm	612	9	spontaneously	spontaneously	RB
cord-022353-q2k2krnm	612	10	develop	develop	VBP
cord-022353-q2k2krnm	612	11	autoimmune	autoimmune	JJ
cord-022353-q2k2krnm	612	12	disease	disease	NN
cord-022353-q2k2krnm	612	13	or	or	CC
cord-022353-q2k2krnm	612	14	are	be	VBP
cord-022353-q2k2krnm	612	15	susceptible	susceptible	JJ
cord-022353-q2k2krnm	612	16	to	to	IN
cord-022353-q2k2krnm	612	17	autoimmune	autoimmune	JJ
cord-022353-q2k2krnm	612	18	disease	disease	NN
cord-022353-q2k2krnm	612	19	induction	induction	NN
cord-022353-q2k2krnm	612	20	.	.	.
cord-022353-q2k2krnm	613	1	The	the	DT
cord-022353-q2k2krnm	613	2	details	detail	NNS
cord-022353-q2k2krnm	613	3	of	of	IN
cord-022353-q2k2krnm	613	4	many	many	JJ
cord-022353-q2k2krnm	613	5	of	of	IN
cord-022353-q2k2krnm	613	6	these	these	DT
cord-022353-q2k2krnm	613	7	lines	line	NNS
cord-022353-q2k2krnm	613	8	may	may	MD
cord-022353-q2k2krnm	613	9	be	be	VB
cord-022353-q2k2krnm	613	10	found	find	VBN
cord-022353-q2k2krnm	613	11	in	in	IN
cord-022353-q2k2krnm	613	12	Volume	volume	NN
cord-022353-q2k2krnm	613	13	4	4	CD
cord-022353-q2k2krnm	613	14	,	,	,
cord-022353-q2k2krnm	613	15	Chapters	Chapters	NNPS
cord-022353-q2k2krnm	613	16	l	l	NNP
cord-022353-q2k2krnm	613	17	l	l	NN
cord-022353-q2k2krnm	613	18	and	and	CC
cord-022353-q2k2krnm	613	19	12	12	CD
cord-022353-q2k2krnm	613	20	in	in	IN
cord-022353-q2k2krnm	613	21	this	this	DT
cord-022353-q2k2krnm	613	22	series	series	NN
cord-022353-q2k2krnm	613	23	.	.	.
cord-022353-q2k2krnm	614	1	Autoimmune	autoimmune	JJ
cord-022353-q2k2krnm	614	2	diseases	disease	NNS
cord-022353-q2k2krnm	614	3	in	in	IN
cord-022353-q2k2krnm	614	4	mice	mouse	NNS
cord-022353-q2k2krnm	614	5	include	include	VBP
cord-022353-q2k2krnm	614	6	:	:	:
cord-022353-q2k2krnm	614	7	thyroiditis	thyroiditis	NN
cord-022353-q2k2krnm	614	8	,	,	,
cord-022353-q2k2krnm	614	9	rheumatoid	rheumatoid	NN
cord-022353-q2k2krnm	614	10	arthritis	arthritis	NN
cord-022353-q2k2krnm	614	11	,	,	,
cord-022353-q2k2krnm	614	12	Sj6gren	Sj6gren	NNP
cord-022353-q2k2krnm	614	13	's	's	POS
cord-022353-q2k2krnm	614	14	syndrome	syndrome	NN
cord-022353-q2k2krnm	614	15	(	(	-LRB-
cord-022353-q2k2krnm	614	16	SS	SS	NNP
cord-022353-q2k2krnm	614	17	)	)	-RRB-
cord-022353-q2k2krnm	614	18	,	,	,
cord-022353-q2k2krnm	614	19	hemolytic	hemolytic	JJ
cord-022353-q2k2krnm	614	20	anemia	anemia	NN
cord-022353-q2k2krnm	614	21	,	,	,
cord-022353-q2k2krnm	614	22	lupus	lupus	NN
cord-022353-q2k2krnm	614	23	erythematosus	erythematosus	NN
cord-022353-q2k2krnm	614	24	,	,	,
cord-022353-q2k2krnm	614	25	type	type	NN
cord-022353-q2k2krnm	614	26	1	1	CD
cord-022353-q2k2krnm	614	27	diabetes	diabetes	NN
cord-022353-q2k2krnm	614	28	mellitus	mellitus	NN
cord-022353-q2k2krnm	614	29	,	,	,
cord-022353-q2k2krnm	614	30	experimental	experimental	JJ
cord-022353-q2k2krnm	614	31	allergic	allergic	JJ
cord-022353-q2k2krnm	614	32	encephalitis	encephalitis	RB
cord-022353-q2k2krnm	614	33	,	,	,
cord-022353-q2k2krnm	614	34	oophoritis	oophoritis	NN
cord-022353-q2k2krnm	614	35	,	,	,
cord-022353-q2k2krnm	614	36	orchitis	orchitis	NN
cord-022353-q2k2krnm	614	37	,	,	,
cord-022353-q2k2krnm	614	38	gastritis	gastritis	NN
cord-022353-q2k2krnm	614	39	,	,	,
cord-022353-q2k2krnm	614	40	ulcerative	ulcerative	JJ
cord-022353-q2k2krnm	614	41	colitis	colitis	NN
cord-022353-q2k2krnm	614	42	,	,	,
cord-022353-q2k2krnm	614	43	and	and	CC
cord-022353-q2k2krnm	614	44	polyendocrine	polyendocrine	NN
cord-022353-q2k2krnm	614	45	disease	disease	NN
cord-022353-q2k2krnm	614	46	(	(	-LRB-
cord-022353-q2k2krnm	614	47	Boyton	Boyton	NNP
cord-022353-q2k2krnm	614	48	and	and	CC
cord-022353-q2k2krnm	614	49	Altmann	Altmann	NNP
cord-022353-q2k2krnm	614	50	2002	2002	CD
cord-022353-q2k2krnm	614	51	;	;	:
cord-022353-q2k2krnm	614	52	Ravirajan	Ravirajan	NNP
cord-022353-q2k2krnm	614	53	and	and	CC
cord-022353-q2k2krnm	614	54	Isenberg	Isenberg	NNP
cord-022353-q2k2krnm	614	55	2002	2002	CD
cord-022353-q2k2krnm	614	56	;	;	:
cord-022353-q2k2krnm	614	57	Sakaguchi	Sakaguchi	NNP
cord-022353-q2k2krnm	614	58	2000	2000	CD
cord-022353-q2k2krnm	614	59	)	)	-RRB-
cord-022353-q2k2krnm	614	60	.	.	.
cord-022353-q2k2krnm	615	1	Antibodies	antibody	NNS
cord-022353-q2k2krnm	615	2	directed	direct	VBN
cord-022353-q2k2krnm	615	3	to	to	IN
cord-022353-q2k2krnm	615	4	self	self	NN
cord-022353-q2k2krnm	615	5	-	-	HYPH
cord-022353-q2k2krnm	615	6	antigens	antigen	NNS
cord-022353-q2k2krnm	615	7	in	in	IN
cord-022353-q2k2krnm	615	8	the	the	DT
cord-022353-q2k2krnm	615	9	mouse	mouse	NN
cord-022353-q2k2krnm	615	10	have	have	VBP
cord-022353-q2k2krnm	615	11	been	be	VBN
cord-022353-q2k2krnm	615	12	quantified	quantify	VBN
cord-022353-q2k2krnm	615	13	using	use	VBG
cord-022353-q2k2krnm	615	14	a	a	DT
cord-022353-q2k2krnm	615	15	wide	wide	JJ
cord-022353-q2k2krnm	615	16	range	range	NN
cord-022353-q2k2krnm	615	17	of	of	IN
cord-022353-q2k2krnm	615	18	methods	method	NNS
cord-022353-q2k2krnm	615	19	from	from	IN
cord-022353-q2k2krnm	615	20	immunofluorescence	immunofluorescence	NN
cord-022353-q2k2krnm	615	21	to	to	IN
cord-022353-q2k2krnm	615	22	ELISA	ELISA	NNP
cord-022353-q2k2krnm	615	23	.	.	.
cord-022353-q2k2krnm	616	1	Table	table	NN
cord-022353-q2k2krnm	616	2	6	6	CD
cord-022353-q2k2krnm	617	1	-3	-3	NNP
cord-022353-q2k2krnm	617	2	lists	list	VBZ
cord-022353-q2k2krnm	617	3	the	the	DT
cord-022353-q2k2krnm	617	4	commercially	commercially	RB
cord-022353-q2k2krnm	617	5	available	available	JJ
cord-022353-q2k2krnm	617	6	ELISA	ELISA	NNP
cord-022353-q2k2krnm	617	7	kits	kit	NNS
cord-022353-q2k2krnm	617	8	used	use	VBN
cord-022353-q2k2krnm	617	9	to	to	TO
cord-022353-q2k2krnm	617	10	quantify	quantify	VB
cord-022353-q2k2krnm	617	11	murine	murine	JJ
cord-022353-q2k2krnm	617	12	autoantibodies	autoantibody	NNS
cord-022353-q2k2krnm	617	13	.	.	.
cord-022353-q2k2krnm	618	1	Those	those	DT
cord-022353-q2k2krnm	618	2	antigenic	antigenic	JJ
cord-022353-q2k2krnm	618	3	targets	target	NNS
cord-022353-q2k2krnm	618	4	associated	associate	VBN
cord-022353-q2k2krnm	618	5	with	with	IN
cord-022353-q2k2krnm	618	6	systemic	systemic	JJ
cord-022353-q2k2krnm	618	7	lupus	lupus	NN
cord-022353-q2k2krnm	618	8	erythematosus	erythematosus	NN
cord-022353-q2k2krnm	618	9	include	include	VBP
cord-022353-q2k2krnm	618	10	:	:	:
cord-022353-q2k2krnm	618	11	cardiolipin	cardiolipin	NNP
cord-022353-q2k2krnm	618	12	,	,	,
cord-022353-q2k2krnm	618	13	double	double	RB
cord-022353-q2k2krnm	618	14	-	-	HYPH
cord-022353-q2k2krnm	618	15	stranded	strand	VBN
cord-022353-q2k2krnm	618	16	deoxyribonucleic	deoxyribonucleic	NN
cord-022353-q2k2krnm	618	17	acid	acid	NN
cord-022353-q2k2krnm	618	18	(	(	-LRB-
cord-022353-q2k2krnm	618	19	dsDNA	dsdna	RB
cord-022353-q2k2krnm	618	20	)	)	-RRB-
cord-022353-q2k2krnm	618	21	,	,	,
cord-022353-q2k2krnm	618	22	single	single	RB
cord-022353-q2k2krnm	618	23	-	-	HYPH
cord-022353-q2k2krnm	618	24	stranded	strand	VBN
cord-022353-q2k2krnm	618	25	deoxyribonucleic	deoxyribonucleic	NN
cord-022353-q2k2krnm	618	26	acid	acid	NN
cord-022353-q2k2krnm	618	27	(	(	-LRB-
cord-022353-q2k2krnm	618	28	ssDNA	ssdna	NN
cord-022353-q2k2krnm	618	29	)	)	-RRB-
cord-022353-q2k2krnm	618	30	,	,	,
cord-022353-q2k2krnm	618	31	histone	histone	NN
cord-022353-q2k2krnm	618	32	,	,	,
cord-022353-q2k2krnm	618	33	[	[	-LRB-
cord-022353-q2k2krnm	618	34	~-2	~-2	CD
cord-022353-q2k2krnm	618	35	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	618	36	,	,	,
cord-022353-q2k2krnm	618	37	proliferating	proliferate	VBG
cord-022353-q2k2krnm	618	38	cell	cell	NN
cord-022353-q2k2krnm	618	39	nuclear	nuclear	JJ
cord-022353-q2k2krnm	618	40	antigen	antigen	NN
cord-022353-q2k2krnm	618	41	(	(	-LRB-
cord-022353-q2k2krnm	618	42	PCNA	PCNA	NNP
cord-022353-q2k2krnm	618	43	)	)	-RRB-
cord-022353-q2k2krnm	618	44	,	,	,
cord-022353-q2k2krnm	618	45	neutrophil	neutrophil	NN
cord-022353-q2k2krnm	618	46	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	618	47	antibody	antibody	NN
cord-022353-q2k2krnm	618	48	(	(	-LRB-
cord-022353-q2k2krnm	618	49	cANCA	cANCA	NNP
cord-022353-q2k2krnm	618	50	)	)	-RRB-
cord-022353-q2k2krnm	618	51	,	,	,
cord-022353-q2k2krnm	618	52	ribosomal	ribosomal	NNP
cord-022353-q2k2krnm	618	53	P	p	NN
cord-022353-q2k2krnm	618	54	,	,	,
cord-022353-q2k2krnm	618	55	and	and	CC
cord-022353-q2k2krnm	618	56	Smith	Smith	NNP
cord-022353-q2k2krnm	618	57	.	.	.
cord-022353-q2k2krnm	619	1	Antigenic	antigenic	JJ
cord-022353-q2k2krnm	619	2	targets	target	NNS
cord-022353-q2k2krnm	619	3	for	for	IN
cord-022353-q2k2krnm	619	4	arthritis	arthritis	NN
cord-022353-q2k2krnm	619	5	include	include	VBP
cord-022353-q2k2krnm	619	6	:	:	:
cord-022353-q2k2krnm	619	7	rheumatoid	rheumatoid	NNP
cord-022353-q2k2krnm	619	8	factor	factor	NN
cord-022353-q2k2krnm	619	9	(	(	-LRB-
cord-022353-q2k2krnm	619	10	RF	RF	NNP
cord-022353-q2k2krnm	619	11	)	)	-RRB-
cord-022353-q2k2krnm	619	12	,	,	,
cord-022353-q2k2krnm	619	13	collagen	collagen	NN
cord-022353-q2k2krnm	619	14	type	type	NN
cord-022353-q2k2krnm	619	15	1	1	CD
cord-022353-q2k2krnm	619	16	,	,	,
cord-022353-q2k2krnm	619	17	collagen	collagen	NN
cord-022353-q2k2krnm	619	18	type	type	NN
cord-022353-q2k2krnm	619	19	2	2	CD
cord-022353-q2k2krnm	619	20	,	,	,
cord-022353-q2k2krnm	619	21	and	and	CC
cord-022353-q2k2krnm	619	22	ssDNA	ssdna	NN
cord-022353-q2k2krnm	619	23	.	.	.
cord-022353-q2k2krnm	620	1	Antibodies	antibody	NNS
cord-022353-q2k2krnm	620	2	against	against	IN
cord-022353-q2k2krnm	620	3	insulin	insulin	NN
cord-022353-q2k2krnm	620	4	and	and	CC
cord-022353-q2k2krnm	620	5	glutamic	glutamic	NN
cord-022353-q2k2krnm	620	6	acid	acid	NN
cord-022353-q2k2krnm	620	7	decarboxylase	decarboxylase	NN
cord-022353-q2k2krnm	620	8	are	be	VBP
cord-022353-q2k2krnm	620	9	seen	see	VBN
cord-022353-q2k2krnm	620	10	in	in	IN
cord-022353-q2k2krnm	620	11	type	type	NN
cord-022353-q2k2krnm	620	12	1	1	CD
cord-022353-q2k2krnm	620	13	(	(	-LRB-
cord-022353-q2k2krnm	620	14	juvenile	juvenile	JJ
cord-022353-q2k2krnm	620	15	)	)	-RRB-
cord-022353-q2k2krnm	620	16	diabetes	diabetes	NN
cord-022353-q2k2krnm	620	17	.	.	.
cord-022353-q2k2krnm	621	1	Mixed	mixed	JJ
cord-022353-q2k2krnm	621	2	connective	connective	JJ
cord-022353-q2k2krnm	621	3	tissue	tissue	NN
cord-022353-q2k2krnm	621	4	diseases	disease	NNS
cord-022353-q2k2krnm	621	5	are	be	VBP
cord-022353-q2k2krnm	621	6	characterized	characterize	VBN
cord-022353-q2k2krnm	621	7	by	by	IN
cord-022353-q2k2krnm	621	8	antibodies	antibody	NNS
cord-022353-q2k2krnm	621	9	to	to	IN
cord-022353-q2k2krnm	621	10	ribonuclearprotein	ribonuclearprotein	NNP
cord-022353-q2k2krnm	621	11	(	(	-LRB-
cord-022353-q2k2krnm	621	12	RNP	RNP	NNP
cord-022353-q2k2krnm	621	13	)	)	-RRB-
cord-022353-q2k2krnm	621	14	.	.	.
cord-022353-q2k2krnm	622	1	Antibodies	antibody	NNS
cord-022353-q2k2krnm	622	2	to	to	IN
cord-022353-q2k2krnm	622	3	myeloperoxidase	myeloperoxidase	VB
cord-022353-q2k2krnm	622	4	(	(	-LRB-
cord-022353-q2k2krnm	622	5	MPO	MPO	NNP
cord-022353-q2k2krnm	622	6	)	)	-RRB-
cord-022353-q2k2krnm	622	7	may	may	MD
cord-022353-q2k2krnm	622	8	be	be	VB
cord-022353-q2k2krnm	622	9	observed	observe	VBN
cord-022353-q2k2krnm	622	10	in	in	IN
cord-022353-q2k2krnm	622	11	vasculitis	vasculitis	NN
cord-022353-q2k2krnm	622	12	.	.	.
cord-022353-q2k2krnm	623	1	Mice	mouse	NNS
cord-022353-q2k2krnm	623	2	with	with	IN
cord-022353-q2k2krnm	623	3	SS	SS	NNP
cord-022353-q2k2krnm	623	4	develop	develop	VBP
cord-022353-q2k2krnm	623	5	autoantibodies	autoantibody	NNS
cord-022353-q2k2krnm	623	6	to	to	IN
cord-022353-q2k2krnm	624	1	SS	SS	NNP
cord-022353-q2k2krnm	624	2	antigens	antigen	NNS
cord-022353-q2k2krnm	624	3	A	A	NNP
cord-022353-q2k2krnm	624	4	and	and	CC
cord-022353-q2k2krnm	624	5	B	B	NNP
cord-022353-q2k2krnm	624	6	(	(	-LRB-
cord-022353-q2k2krnm	624	7	SSA	SSA	NNP
cord-022353-q2k2krnm	624	8	and	and	CC
cord-022353-q2k2krnm	624	9	SSB	SSB	NNP
cord-022353-q2k2krnm	624	10	,	,	,
cord-022353-q2k2krnm	624	11	respectively	respectively	RB
cord-022353-q2k2krnm	624	12	)	)	-RRB-
cord-022353-q2k2krnm	624	13	.	.	.
cord-022353-q2k2krnm	625	1	Panels	panel	NNS
cord-022353-q2k2krnm	625	2	containing	contain	VBG
cord-022353-q2k2krnm	625	3	14	14	CD
cord-022353-q2k2krnm	625	4	autoantigens	autoantigen	NNS
cord-022353-q2k2krnm	625	5	are	be	VBP
cord-022353-q2k2krnm	625	6	available	available	JJ
cord-022353-q2k2krnm	625	7	as	as	IN
cord-022353-q2k2krnm	625	8	multiplex	multiplex	JJ
cord-022353-q2k2krnm	625	9	assays	assay	NNS
cord-022353-q2k2krnm	625	10	for	for	IN
cord-022353-q2k2krnm	625	11	quantifying	quantify	VBG
cord-022353-q2k2krnm	625	12	murine	murine	JJ
cord-022353-q2k2krnm	625	13	autoantibodies	autoantibody	NNS
cord-022353-q2k2krnm	625	14	.	.	.
cord-022353-q2k2krnm	626	1	a.	a.	NN
cord-022353-q2k2krnm	626	2	INTERLEUKINS	INTERLEUKINS	NNP
cord-022353-q2k2krnm	626	3	(	(	-LRB-
cord-022353-q2k2krnm	626	4	IL	IL	NNP
cord-022353-q2k2krnm	626	5	)	)	-RRB-
cord-022353-q2k2krnm	627	1	(	(	-LRB-
cord-022353-q2k2krnm	627	2	ILs	il	NNS
cord-022353-q2k2krnm	627	3	are	be	VBP
cord-022353-q2k2krnm	627	4	cytokines	cytokine	NNS
cord-022353-q2k2krnm	627	5	that	that	WDT
cord-022353-q2k2krnm	627	6	are	be	VBP
cord-022353-q2k2krnm	627	7	secreted	secrete	VBN
cord-022353-q2k2krnm	627	8	by	by	IN
cord-022353-q2k2krnm	627	9	leukocytes	leukocyte	NNS
cord-022353-q2k2krnm	627	10	and	and	CC
cord-022353-q2k2krnm	627	11	act	act	VB
cord-022353-q2k2krnm	627	12	on	on	IN
cord-022353-q2k2krnm	627	13	other	other	JJ
cord-022353-q2k2krnm	627	14	leukocytes	leukocyte	NNS
cord-022353-q2k2krnm	627	15	.	.	.
cord-022353-q2k2krnm	628	1	Interleukins	interleukin	NNS
cord-022353-q2k2krnm	628	2	have	have	VBP
cord-022353-q2k2krnm	628	3	been	be	VBN
cord-022353-q2k2krnm	628	4	classified	classify	VBN
cord-022353-q2k2krnm	628	5	based	base	VBN
cord-022353-q2k2krnm	628	6	on	on	IN
cord-022353-q2k2krnm	628	7	the	the	DT
cord-022353-q2k2krnm	628	8	secretory	secretory	JJ
cord-022353-q2k2krnm	628	9	cell	cell	NN
cord-022353-q2k2krnm	628	10	type	type	NN
cord-022353-q2k2krnm	628	11	(	(	-LRB-
cord-022353-q2k2krnm	628	12	i.e.	i.e.	FW
cord-022353-q2k2krnm	628	13	,	,	,
cord-022353-q2k2krnm	628	14	monokines	monokine	NNS
cord-022353-q2k2krnm	628	15	vs.	vs.	IN
cord-022353-q2k2krnm	628	16	lymphokines	lymphokine	NNS
cord-022353-q2k2krnm	628	17	)	)	-RRB-
cord-022353-q2k2krnm	628	18	,	,	,
cord-022353-q2k2krnm	628	19	and	and	CC
cord-022353-q2k2krnm	628	20	they	-PRON-	PRP
cord-022353-q2k2krnm	628	21	have	have	VBP
cord-022353-q2k2krnm	628	22	been	be	VBN
cord-022353-q2k2krnm	628	23	classified	classify	VBN
cord-022353-q2k2krnm	628	24	based	base	VBN
cord-022353-q2k2krnm	628	25	on	on	IN
cord-022353-q2k2krnm	628	26	whether	whether	IN
cord-022353-q2k2krnm	628	27	they	-PRON-	PRP
cord-022353-q2k2krnm	628	28	are	be	VBP
cord-022353-q2k2krnm	628	29	primarily	primarily	RB
cord-022353-q2k2krnm	628	30	involved	involve	VBN
cord-022353-q2k2krnm	628	31	in	in	IN
cord-022353-q2k2krnm	628	32	innate	innate	JJ
cord-022353-q2k2krnm	628	33	(	(	-LRB-
cord-022353-q2k2krnm	628	34	IL-1	IL-1	NNP
cord-022353-q2k2krnm	628	35	,	,	,
cord-022353-q2k2krnm	628	36	IL-6	IL-6	NNP
cord-022353-q2k2krnm	628	37	,	,	,
cord-022353-q2k2krnm	628	38	IL-12	IL-12	NNP
cord-022353-q2k2krnm	628	39	,	,	,
cord-022353-q2k2krnm	628	40	TNF	TNF	NNP
cord-022353-q2k2krnm	628	41	-	-	HYPH
cord-022353-q2k2krnm	628	42	t~	t~	NNP
cord-022353-q2k2krnm	628	43	,	,	,
cord-022353-q2k2krnm	628	44	IFN	IFN	NNP
cord-022353-q2k2krnm	628	45	-	-	HYPH
cord-022353-q2k2krnm	628	46	t~	t~	NNP
cord-022353-q2k2krnm	628	47	)	)	-RRB-
cord-022353-q2k2krnm	628	48	,	,	,
cord-022353-q2k2krnm	628	49	or	or	CC
cord-022353-q2k2krnm	628	50	adaptive	adaptive	JJ
cord-022353-q2k2krnm	628	51	(	(	-LRB-
cord-022353-q2k2krnm	628	52	IL-2	IL-2	NNP
cord-022353-q2k2krnm	628	53	,	,	,
cord-022353-q2k2krnm	628	54	IL-4	IL-4	NNP
cord-022353-q2k2krnm	628	55	,	,	,
cord-022353-q2k2krnm	628	56	IL-5	IL-5	NNP
cord-022353-q2k2krnm	628	57	,	,	,
cord-022353-q2k2krnm	628	58	IL-10	IL-10	NNP
cord-022353-q2k2krnm	628	59	)	)	-RRB-
cord-022353-q2k2krnm	628	60	immunity	immunity	NN
cord-022353-q2k2krnm	628	61	.	.	.
cord-022353-q2k2krnm	629	1	Commercially	commercially	RB
cord-022353-q2k2krnm	629	2	available	available	JJ
cord-022353-q2k2krnm	629	3	ELISA	ELISA	NNP
cord-022353-q2k2krnm	629	4	kits	kit	NNS
cord-022353-q2k2krnm	629	5	are	be	VBP
cord-022353-q2k2krnm	629	6	available	available	JJ
cord-022353-q2k2krnm	629	7	to	to	TO
cord-022353-q2k2krnm	629	8	quantify	quantify	VB
cord-022353-q2k2krnm	629	9	most	most	JJS
cord-022353-q2k2krnm	629	10	murine	murine	JJ
cord-022353-q2k2krnm	629	11	interleukins	interleukin	NNS
cord-022353-q2k2krnm	629	12	,	,	,
cord-022353-q2k2krnm	629	13	as	as	IN
cord-022353-q2k2krnm	629	14	demonstrated	demonstrate	VBN
cord-022353-q2k2krnm	629	15	in	in	IN
cord-022353-q2k2krnm	629	16	Table	Table	NNP
cord-022353-q2k2krnm	629	17	6	6	CD
cord-022353-q2k2krnm	629	18	-3	-3	NNP
cord-022353-q2k2krnm	629	19	.	.	.
cord-022353-q2k2krnm	630	1	i.	i.	LS
cord-022353-q2k2krnm	630	2	INTERLEUKIN-1	interleukin-1	NN
cord-022353-q2k2krnm	630	3	(	(	-LRB-
cord-022353-q2k2krnm	630	4	IL-1	IL-1	NNP
cord-022353-q2k2krnm	630	5	)	)	-RRB-
cord-022353-q2k2krnm	631	1	IL-1	IL-1	NNP
cord-022353-q2k2krnm	631	2	is	be	VBZ
cord-022353-q2k2krnm	631	3	a	a	DT
cord-022353-q2k2krnm	631	4	name	name	NN
cord-022353-q2k2krnm	631	5	for	for	IN
cord-022353-q2k2krnm	631	6	two	two	CD
cord-022353-q2k2krnm	631	7	proteins	protein	NNS
cord-022353-q2k2krnm	631	8	,	,	,
cord-022353-q2k2krnm	631	9	IL	IL	NNP
cord-022353-q2k2krnm	631	10	-	-	HYPH
cord-022353-q2k2krnm	631	11	lt~	lt~	FW
cord-022353-q2k2krnm	631	12	and	and	CC
cord-022353-q2k2krnm	632	1	IL-1	IL-1	NNP
cord-022353-q2k2krnm	632	2	[	[	-LRB-
cord-022353-q2k2krnm	632	3	3	3	CD
cord-022353-q2k2krnm	632	4	,	,	,
cord-022353-q2k2krnm	632	5	that	that	WDT
cord-022353-q2k2krnm	632	6	are	be	VBP
cord-022353-q2k2krnm	632	7	encoded	encode	VBN
cord-022353-q2k2krnm	632	8	by	by	IN
cord-022353-q2k2krnm	632	9	separate	separate	JJ
cord-022353-q2k2krnm	632	10	genes	gene	NNS
cord-022353-q2k2krnm	632	11	.	.	.
cord-022353-q2k2krnm	633	1	Along	along	IN
cord-022353-q2k2krnm	633	2	with	with	IN
cord-022353-q2k2krnm	633	3	IL-1	IL-1	NNP
cord-022353-q2k2krnm	633	4	receptor	receptor	NN
cord-022353-q2k2krnm	633	5	antagonist	antagonist	NN
cord-022353-q2k2krnm	633	6	,	,	,
cord-022353-q2k2krnm	633	7	IL-18	IL-18	NNP
cord-022353-q2k2krnm	633	8	,	,	,
cord-022353-q2k2krnm	633	9	IL-6	IL-6	NNP
cord-022353-q2k2krnm	633	10	,	,	,
cord-022353-q2k2krnm	633	11	and	and	CC
cord-022353-q2k2krnm	633	12	TNF	TNF	NNP
cord-022353-q2k2krnm	633	13	-	-	HYPH
cord-022353-q2k2krnm	633	14	t~	t~	NNP
cord-022353-q2k2krnm	633	15	,	,	,
cord-022353-q2k2krnm	633	16	these	these	DT
cord-022353-q2k2krnm	633	17	proteins	protein	NNS
cord-022353-q2k2krnm	633	18	modulate	modulate	VBP
cord-022353-q2k2krnm	633	19	acute	acute	JJ
cord-022353-q2k2krnm	633	20	inflammation	inflammation	NN
cord-022353-q2k2krnm	633	21	.	.	.
cord-022353-q2k2krnm	634	1	The	the	DT
cord-022353-q2k2krnm	634	2	effects	effect	NNS
cord-022353-q2k2krnm	634	3	of	of	IN
cord-022353-q2k2krnm	634	4	IL-1	IL-1	NNP
cord-022353-q2k2krnm	634	5	are	be	VBP
cord-022353-q2k2krnm	634	6	pleotrophic	pleotrophic	JJ
cord-022353-q2k2krnm	634	7	and	and	CC
cord-022353-q2k2krnm	634	8	involve	involve	VBP
cord-022353-q2k2krnm	634	9	bone	bone	NN
cord-022353-q2k2krnm	634	10	remodeling	remodeling	NN
cord-022353-q2k2krnm	634	11	,	,	,
cord-022353-q2k2krnm	634	12	insulin	insulin	NN
cord-022353-q2k2krnm	634	13	secretion	secretion	NN
cord-022353-q2k2krnm	634	14	,	,	,
cord-022353-q2k2krnm	634	15	appetite	appetite	NN
cord-022353-q2k2krnm	634	16	regulation	regulation	NN
cord-022353-q2k2krnm	634	17	,	,	,
cord-022353-q2k2krnm	634	18	fever	fever	NN
cord-022353-q2k2krnm	634	19	induction	induction	NN
cord-022353-q2k2krnm	634	20	,	,	,
cord-022353-q2k2krnm	634	21	neuronal	neuronal	JJ
cord-022353-q2k2krnm	634	22	development	development	NN
cord-022353-q2k2krnm	634	23	,	,	,
cord-022353-q2k2krnm	634	24	and	and	CC
cord-022353-q2k2krnm	634	25	many	many	JJ
cord-022353-q2k2krnm	634	26	others	other	NNS
cord-022353-q2k2krnm	634	27	.	.	.
cord-022353-q2k2krnm	635	1	Both	both	DT
cord-022353-q2k2krnm	636	1	IL-1	IL-1	NNP
cord-022353-q2k2krnm	636	2	o~	o~	NNP
cord-022353-q2k2krnm	636	3	and	and	CC
cord-022353-q2k2krnm	637	1	IL-1	IL-1	NNP
cord-022353-q2k2krnm	637	2	[	[	-LRB-
cord-022353-q2k2krnm	637	3	3	3	CD
cord-022353-q2k2krnm	637	4	are	be	VBP
cord-022353-q2k2krnm	637	5	secreted	secrete	VBN
cord-022353-q2k2krnm	637	6	as	as	IN
cord-022353-q2k2krnm	637	7	269	269	CD
cord-022353-q2k2krnm	637	8	-	-	SYM
cord-022353-q2k2krnm	637	9	271	271	CD
cord-022353-q2k2krnm	637	10	amino	amino	NN
cord-022353-q2k2krnm	637	11	acid	acid	NN
cord-022353-q2k2krnm	637	12	(	(	-LRB-
cord-022353-q2k2krnm	637	13	aa	aa	NNP
cord-022353-q2k2krnm	637	14	)	)	-RRB-
cord-022353-q2k2krnm	637	15	pro	pro	JJ
cord-022353-q2k2krnm	637	16	-	-	NNS
cord-022353-q2k2krnm	637	17	cytokines	cytokine	NNS
cord-022353-q2k2krnm	637	18	that	that	WDT
cord-022353-q2k2krnm	637	19	are	be	VBP
cord-022353-q2k2krnm	637	20	enzymatically	enzymatically	RB
cord-022353-q2k2krnm	637	21	cleaved	cleave	VBN
cord-022353-q2k2krnm	637	22	into	into	IN
cord-022353-q2k2krnm	637	23	bioactive	bioactive	JJ
cord-022353-q2k2krnm	637	24	17-kDa	17-kda	CD
cord-022353-q2k2krnm	637	25	segments	segment	NNS
cord-022353-q2k2krnm	637	26	.	.	.
cord-022353-q2k2krnm	638	1	Unlike	unlike	IN
cord-022353-q2k2krnm	638	2	IL-1	IL-1	NNP
cord-022353-q2k2krnm	638	3	[	[	-LRB-
cord-022353-q2k2krnm	638	4	3	3	CD
cord-022353-q2k2krnm	638	5	,	,	,
cord-022353-q2k2krnm	638	6	the	the	DT
cord-022353-q2k2krnm	638	7	intact	intact	JJ
cord-022353-q2k2krnm	638	8	procytokine	procytokine	NN
cord-022353-q2k2krnm	638	9	of	of	IN
cord-022353-q2k2krnm	638	10	IL-1	IL-1	NNP
cord-022353-q2k2krnm	638	11	ct	ct	NNP
cord-022353-q2k2krnm	638	12	is	be	VBZ
cord-022353-q2k2krnm	638	13	also	also	RB
cord-022353-q2k2krnm	638	14	bioactive	bioactive	JJ
cord-022353-q2k2krnm	638	15	,	,	,
cord-022353-q2k2krnm	638	16	both	both	DT
cord-022353-q2k2krnm	638	17	within	within	IN
cord-022353-q2k2krnm	638	18	the	the	DT
cord-022353-q2k2krnm	638	19	cytoplasm	cytoplasm	NN
cord-022353-q2k2krnm	638	20	and	and	CC
cord-022353-q2k2krnm	638	21	on	on	IN
cord-022353-q2k2krnm	638	22	the	the	DT
cord-022353-q2k2krnm	638	23	cell	cell	NN
cord-022353-q2k2krnm	638	24	surface	surface	NN
cord-022353-q2k2krnm	638	25	,	,	,
cord-022353-q2k2krnm	638	26	where	where	WRB
cord-022353-q2k2krnm	638	27	it	-PRON-	PRP
cord-022353-q2k2krnm	638	28	is	be	VBZ
cord-022353-q2k2krnm	638	29	anchored	anchor	VBN
cord-022353-q2k2krnm	638	30	to	to	IN
cord-022353-q2k2krnm	638	31	the	the	DT
cord-022353-q2k2krnm	638	32	cell	cell	NN
cord-022353-q2k2krnm	638	33	membrane	membrane	NN
cord-022353-q2k2krnm	638	34	via	via	IN
cord-022353-q2k2krnm	638	35	a	a	DT
cord-022353-q2k2krnm	638	36	mannose	mannose	JJ
cord-022353-q2k2krnm	638	37	glycosylation	glycosylation	NN
cord-022353-q2k2krnm	638	38	residue	residue	NN
cord-022353-q2k2krnm	638	39	that	that	WDT
cord-022353-q2k2krnm	638	40	attaches	attach	VBZ
cord-022353-q2k2krnm	638	41	to	to	IN
cord-022353-q2k2krnm	638	42	the	the	DT
cord-022353-q2k2krnm	638	43	membrane	membrane	NN
cord-022353-q2k2krnm	638	44	-	-	HYPH
cord-022353-q2k2krnm	638	45	associated	associate	VBN
cord-022353-q2k2krnm	638	46	lectin	lectin	NN
cord-022353-q2k2krnm	638	47	.	.	.
cord-022353-q2k2krnm	639	1	There	there	EX
cord-022353-q2k2krnm	639	2	is	be	VBZ
cord-022353-q2k2krnm	639	3	78	78	CD
cord-022353-q2k2krnm	639	4	%	%	NN
cord-022353-q2k2krnm	639	5	sequence	sequence	NN
cord-022353-q2k2krnm	639	6	identify	identify	VBP
cord-022353-q2k2krnm	639	7	between	between	IN
cord-022353-q2k2krnm	639	8	mouse	mouse	NN
cord-022353-q2k2krnm	639	9	and	and	CC
cord-022353-q2k2krnm	639	10	human	human	JJ
cord-022353-q2k2krnm	639	11	IL	IL	NNP
cord-022353-q2k2krnm	639	12	-	-	HYPH
cord-022353-q2k2krnm	639	13	I~	I~	NNP
cord-022353-q2k2krnm	639	14	genes	gene	NNS
cord-022353-q2k2krnm	639	15	and	and	CC
cord-022353-q2k2krnm	639	16	58	58	CD
cord-022353-q2k2krnm	639	17	%	%	NN
cord-022353-q2k2krnm	639	18	identity	identity	NN
cord-022353-q2k2krnm	639	19	between	between	IN
cord-022353-q2k2krnm	639	20	mouse	mouse	NN
cord-022353-q2k2krnm	639	21	and	and	CC
cord-022353-q2k2krnm	639	22	human	human	JJ
cord-022353-q2k2krnm	639	23	IL-1	IL-1	NNP
cord-022353-q2k2krnm	639	24	t~	t~	NNP
cord-022353-q2k2krnm	639	25	genes	gene	NNS
cord-022353-q2k2krnm	639	26	.	.	.
cord-022353-q2k2krnm	640	1	A	a	DT
cord-022353-q2k2krnm	640	2	third	third	JJ
cord-022353-q2k2krnm	640	3	gene	gene	NN
cord-022353-q2k2krnm	640	4	encodes	encode	VBZ
cord-022353-q2k2krnm	640	5	IL-1	IL-1	NNP
cord-022353-q2k2krnm	640	6	receptor	receptor	NN
cord-022353-q2k2krnm	640	7	antagonist	antagonist	NN
cord-022353-q2k2krnm	640	8	,	,	,
cord-022353-q2k2krnm	640	9	a	a	DT
cord-022353-q2k2krnm	640	10	soluble	soluble	JJ
cord-022353-q2k2krnm	640	11	25-kDa	25-kda	CD
cord-022353-q2k2krnm	640	12	molecule	molecule	NN
cord-022353-q2k2krnm	640	13	with	with	IN
cord-022353-q2k2krnm	640	14	19	19	CD
cord-022353-q2k2krnm	640	15	%	%	NN
cord-022353-q2k2krnm	640	16	sequence	sequence	NN
cord-022353-q2k2krnm	640	17	homology	homology	NN
cord-022353-q2k2krnm	640	18	to	to	IN
cord-022353-q2k2krnm	640	19	IL	IL	NNP
cord-022353-q2k2krnm	640	20	-	-	HYPH
cord-022353-q2k2krnm	640	21	lt~	lt~	NNP
cord-022353-q2k2krnm	640	22	and	and	CC
cord-022353-q2k2krnm	640	23	26	26	CD
cord-022353-q2k2krnm	640	24	%	%	NN
cord-022353-q2k2krnm	640	25	homology	homology	NN
cord-022353-q2k2krnm	640	26	with	with	IN
cord-022353-q2k2krnm	640	27	IL-113	il-113	NN
cord-022353-q2k2krnm	640	28	.	.	.
cord-022353-q2k2krnm	641	1	Mouse	Mouse	NNP
cord-022353-q2k2krnm	641	2	IL	IL	NNP
cord-022353-q2k2krnm	641	3	-	-	HYPH
cord-022353-q2k2krnm	641	4	lra	lra	NNP
cord-022353-q2k2krnm	641	5	is	be	VBZ
cord-022353-q2k2krnm	641	6	75	75	CD
cord-022353-q2k2krnm	641	7	%	%	NN
cord-022353-q2k2krnm	641	8	homologous	homologous	JJ
cord-022353-q2k2krnm	641	9	with	with	IN
cord-022353-q2k2krnm	641	10	human	human	JJ
cord-022353-q2k2krnm	641	11	IL	IL	NNP
cord-022353-q2k2krnm	641	12	-	-	HYPH
cord-022353-q2k2krnm	641	13	lra	lra	NNP
cord-022353-q2k2krnm	641	14	.	.	.
cord-022353-q2k2krnm	642	1	There	there	EX
cord-022353-q2k2krnm	642	2	are	be	VBP
cord-022353-q2k2krnm	642	3	two	two	CD
cord-022353-q2k2krnm	642	4	IL-1	IL-1	NNP
cord-022353-q2k2krnm	642	5	receptors	receptor	NNS
cord-022353-q2k2krnm	642	6	,	,	,
cord-022353-q2k2krnm	642	7	types	type	NNS
cord-022353-q2k2krnm	642	8	I	-PRON-	PRP
cord-022353-q2k2krnm	642	9	and	and	CC
cord-022353-q2k2krnm	642	10	II	II	NNP
cord-022353-q2k2krnm	642	11	,	,	,
cord-022353-q2k2krnm	642	12	but	but	CC
cord-022353-q2k2krnm	642	13	only	only	RB
cord-022353-q2k2krnm	642	14	IL-1RI	IL-1RI	NNP
cord-022353-q2k2krnm	642	15	is	be	VBZ
cord-022353-q2k2krnm	642	16	capable	capable	JJ
cord-022353-q2k2krnm	642	17	of	of	IN
cord-022353-q2k2krnm	642	18	signal	signal	NN
cord-022353-q2k2krnm	642	19	transduction	transduction	NN
cord-022353-q2k2krnm	642	20	.	.	.
cord-022353-q2k2krnm	643	1	IL	IL	NNP
cord-022353-q2k2krnm	643	2	-	-	HYPH
cord-022353-q2k2krnm	643	3	lra	lra	NNP
cord-022353-q2k2krnm	643	4	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	643	5	the	the	DT
cord-022353-q2k2krnm	643	6	action	action	NN
cord-022353-q2k2krnm	643	7	of	of	IN
cord-022353-q2k2krnm	643	8	IL	IL	NNP
cord-022353-q2k2krnm	643	9	-	-	HYPH
cord-022353-q2k2krnm	643	10	lt~	lt~	NNP
cord-022353-q2k2krnm	643	11	and	and	CC
cord-022353-q2k2krnm	643	12	IL-1B	IL-1B	NNP
cord-022353-q2k2krnm	643	13	by	by	IN
cord-022353-q2k2krnm	643	14	binding	bind	VBG
cord-022353-q2k2krnm	643	15	IL-1RI	IL-1RI	NNP
cord-022353-q2k2krnm	643	16	.	.	.
cord-022353-q2k2krnm	644	1	A	a	DT
cord-022353-q2k2krnm	644	2	60-kDa	60-kda	CD
cord-022353-q2k2krnm	644	3	form	form	NN
cord-022353-q2k2krnm	644	4	of	of	IN
cord-022353-q2k2krnm	644	5	IL-1RI	IL-1RI	NNP
cord-022353-q2k2krnm	644	6	has	have	VBZ
cord-022353-q2k2krnm	644	7	also	also	RB
cord-022353-q2k2krnm	644	8	been	be	VBN
cord-022353-q2k2krnm	644	9	described	describe	VBN
cord-022353-q2k2krnm	644	10	that	that	WDT
cord-022353-q2k2krnm	644	11	is	be	VBZ
cord-022353-q2k2krnm	644	12	soluble	soluble	JJ
cord-022353-q2k2krnm	644	13	and	and	CC
cord-022353-q2k2krnm	644	14	preferentially	preferentially	RB
cord-022353-q2k2krnm	644	15	binds	bind	VBZ
cord-022353-q2k2krnm	644	16	IL	IL	NNP
cord-022353-q2k2krnm	644	17	-	-	HYPH
cord-022353-q2k2krnm	644	18	lra	lra	NNP
cord-022353-q2k2krnm	644	19	.	.	.
cord-022353-q2k2krnm	645	1	IL-1RII	IL-1RII	NNP
cord-022353-q2k2krnm	645	2	has	have	VBZ
cord-022353-q2k2krnm	645	3	no	no	DT
cord-022353-q2k2krnm	645	4	signal	signal	JJ
cord-022353-q2k2krnm	645	5	transducing	transducing	NN
cord-022353-q2k2krnm	645	6	associated	associate	VBD
cord-022353-q2k2krnm	645	7	protein	protein	NN
cord-022353-q2k2krnm	645	8	and	and	CC
cord-022353-q2k2krnm	645	9	serves	serve	VBZ
cord-022353-q2k2krnm	645	10	to	to	TO
cord-022353-q2k2krnm	645	11	modulate	modulate	VB
cord-022353-q2k2krnm	645	12	levels	level	NNS
cord-022353-q2k2krnm	645	13	of	of	IN
cord-022353-q2k2krnm	645	14	IL-1	IL-1	NNP
cord-022353-q2k2krnm	645	15	t~	t~	NNP
cord-022353-q2k2krnm	645	16	,	,	,
cord-022353-q2k2krnm	645	17	IL	IL	NNP
cord-022353-q2k2krnm	645	18	-	-	HYPH
cord-022353-q2k2krnm	645	19	I[3	I[3	NNP
cord-022353-q2k2krnm	645	20	,	,	,
cord-022353-q2k2krnm	645	21	and	and	CC
cord-022353-q2k2krnm	645	22	IL	IL	NNP
cord-022353-q2k2krnm	645	23	-	-	HYPH
cord-022353-q2k2krnm	645	24	lra	lra	NNP
cord-022353-q2k2krnm	645	25	by	by	IN
cord-022353-q2k2krnm	645	26	binding	bind	VBG
cord-022353-q2k2krnm	645	27	them	-PRON-	PRP
cord-022353-q2k2krnm	645	28	on	on	IN
cord-022353-q2k2krnm	645	29	the	the	DT
cord-022353-q2k2krnm	645	30	cell	cell	NN
cord-022353-q2k2krnm	645	31	surface	surface	NN
cord-022353-q2k2krnm	645	32	.	.	.
cord-022353-q2k2krnm	646	1	It	-PRON-	PRP
cord-022353-q2k2krnm	646	2	can	can	MD
cord-022353-q2k2krnm	646	3	also	also	RB
cord-022353-q2k2krnm	646	4	occur	occur	VB
cord-022353-q2k2krnm	646	5	as	as	IN
cord-022353-q2k2krnm	646	6	a	a	DT
cord-022353-q2k2krnm	646	7	soluble	soluble	JJ
cord-022353-q2k2krnm	646	8	receptor	receptor	NN
cord-022353-q2k2krnm	646	9	.	.	.
cord-022353-q2k2krnm	647	1	With	with	IN
cord-022353-q2k2krnm	647	2	the	the	DT
cord-022353-q2k2krnm	647	3	recent	recent	JJ
cord-022353-q2k2krnm	647	4	finding	finding	NN
cord-022353-q2k2krnm	647	5	of	of	IN
cord-022353-q2k2krnm	647	6	six	six	CD
cord-022353-q2k2krnm	647	7	new	new	JJ
cord-022353-q2k2krnm	647	8	members	member	NNS
cord-022353-q2k2krnm	647	9	in	in	IN
cord-022353-q2k2krnm	647	10	the	the	DT
cord-022353-q2k2krnm	647	11	IL-1	IL-1	NNP
cord-022353-q2k2krnm	647	12	ligand	ligand	NN
cord-022353-q2k2krnm	647	13	family	family	NN
cord-022353-q2k2krnm	647	14	(	(	-LRB-
cord-022353-q2k2krnm	647	15	in	in	IN
cord-022353-q2k2krnm	647	16	humans	human	NNS
cord-022353-q2k2krnm	647	17	)	)	-RRB-
cord-022353-q2k2krnm	647	18	,	,	,
cord-022353-q2k2krnm	647	19	a	a	DT
cord-022353-q2k2krnm	647	20	revised	revise	VBN
cord-022353-q2k2krnm	647	21	nomenclature	nomenclature	NN
cord-022353-q2k2krnm	647	22	for	for	IN
cord-022353-q2k2krnm	647	23	both	both	CC
cord-022353-q2k2krnm	647	24	IL-1	IL-1	NNP
cord-022353-q2k2krnm	647	25	ligands	ligand	NNS
cord-022353-q2k2krnm	647	26	FRED	FRED	NNP
cord-022353-q2k2krnm	647	27	W.	W.	NNP
cord-022353-q2k2krnm	647	28	QUIMBY	QUIMBY	NNP
cord-022353-q2k2krnm	647	29	AND	and	CC
cord-022353-q2k2krnm	647	30	RICHARD	RICHARD	NNP
cord-022353-q2k2krnm	647	31	H.	H.	NNP
cord-022353-q2k2krnm	647	32	LUONG	LUONG	NNP
cord-022353-q2k2krnm	647	33	and	and	CC
cord-022353-q2k2krnm	647	34	IL-1	IL-1	NNP
cord-022353-q2k2krnm	647	35	/	/	,
cord-022353-q2k2krnm	647	36	IL-18	IL-18	NNP
cord-022353-q2k2krnm	648	1	receptor	receptor	NN
cord-022353-q2k2krnm	648	2	families	family	NNS
cord-022353-q2k2krnm	648	3	has	have	VBZ
cord-022353-q2k2krnm	648	4	been	be	VBN
cord-022353-q2k2krnm	648	5	developed	develop	VBN
cord-022353-q2k2krnm	648	6	(	(	-LRB-
cord-022353-q2k2krnm	648	7	Sims	Sims	NNP
cord-022353-q2k2krnm	648	8	2002	2002	CD
cord-022353-q2k2krnm	648	9	)	)	-RRB-
cord-022353-q2k2krnm	648	10	.	.	.
cord-022353-q2k2krnm	649	1	Further	further	JJ
cord-022353-q2k2krnm	649	2	details	detail	NNS
cord-022353-q2k2krnm	649	3	may	may	MD
cord-022353-q2k2krnm	649	4	be	be	VB
cord-022353-q2k2krnm	649	5	found	find	VBN
cord-022353-q2k2krnm	649	6	in	in	IN
cord-022353-q2k2krnm	649	7	Volume	volume	NN
cord-022353-q2k2krnm	649	8	4	4	CD
cord-022353-q2k2krnm	649	9	(	(	-LRB-
cord-022353-q2k2krnm	649	10	Overview	Overview	NNP
cord-022353-q2k2krnm	649	11	and	and	CC
cord-022353-q2k2krnm	649	12	Chapter	Chapter	NNP
cord-022353-q2k2krnm	649	13	8)	8)	NN
cord-022353-q2k2krnm	649	14	of	of	IN
cord-022353-q2k2krnm	649	15	this	this	DT
cord-022353-q2k2krnm	649	16	series	series	NN
cord-022353-q2k2krnm	649	17	.	.	.
cord-022353-q2k2krnm	650	1	ii	ii	NNP
cord-022353-q2k2krnm	650	2	.	.	.
cord-022353-q2k2krnm	651	1	INTERLEUKIN-2	interleukin-2	NN
cord-022353-q2k2krnm	651	2	(	(	-LRB-
cord-022353-q2k2krnm	652	1	IL-2	IL-2	NNP
cord-022353-q2k2krnm	652	2	)	)	-RRB-
cord-022353-q2k2krnm	652	3	IL-2	IL-2	NNP
cord-022353-q2k2krnm	652	4	is	be	VBZ
cord-022353-q2k2krnm	652	5	a	a	DT
cord-022353-q2k2krnm	652	6	lymphokine	lymphokine	NN
cord-022353-q2k2krnm	652	7	secreted	secrete	VBN
cord-022353-q2k2krnm	652	8	by	by	IN
cord-022353-q2k2krnm	652	9	activated	activate	VBN
cord-022353-q2k2krnm	652	10	T	t	NN
cord-022353-q2k2krnm	652	11	-	-	HYPH
cord-022353-q2k2krnm	652	12	helper	helper	NN
cord-022353-q2k2krnm	652	13	cells	cell	NNS
cord-022353-q2k2krnm	652	14	.	.	.
cord-022353-q2k2krnm	653	1	It	-PRON-	PRP
cord-022353-q2k2krnm	653	2	acts	act	VBZ
cord-022353-q2k2krnm	653	3	in	in	IN
cord-022353-q2k2krnm	653	4	an	an	DT
cord-022353-q2k2krnm	653	5	autocrine	autocrine	JJ
cord-022353-q2k2krnm	653	6	fashion	fashion	NN
cord-022353-q2k2krnm	653	7	to	to	TO
cord-022353-q2k2krnm	653	8	induce	induce	VB
cord-022353-q2k2krnm	653	9	the	the	DT
cord-022353-q2k2krnm	653	10	expression	expression	NN
cord-022353-q2k2krnm	653	11	of	of	IN
cord-022353-q2k2krnm	653	12	IL-2	IL-2	NNP
cord-022353-q2k2krnm	653	13	receptor	receptor	NN
cord-022353-q2k2krnm	653	14	on	on	IN
cord-022353-q2k2krnm	653	15	T	T	NNP
cord-022353-q2k2krnm	653	16	cells	cell	NNS
cord-022353-q2k2krnm	653	17	,	,	,
cord-022353-q2k2krnm	653	18	resulting	result	VBG
cord-022353-q2k2krnm	653	19	in	in	IN
cord-022353-q2k2krnm	653	20	T	t	NN
cord-022353-q2k2krnm	653	21	-	-	HYPH
cord-022353-q2k2krnm	653	22	cell	cell	NN
cord-022353-q2k2krnm	653	23	proliferation	proliferation	NN
cord-022353-q2k2krnm	653	24	(	(	-LRB-
cord-022353-q2k2krnm	653	25	Cogoli	Cogoli	NNP
cord-022353-q2k2krnm	653	26	-	-	HYPH
cord-022353-q2k2krnm	653	27	Greuter	Greuter	NNP
cord-022353-q2k2krnm	653	28	et	et	NNP
cord-022353-q2k2krnm	653	29	al	al	NNP
cord-022353-q2k2krnm	653	30	.	.	.
cord-022353-q2k2krnm	653	31	2004	2004	CD
cord-022353-q2k2krnm	653	32	)	)	-RRB-
cord-022353-q2k2krnm	653	33	.	.	.
cord-022353-q2k2krnm	654	1	IL-2	IL-2	NNP
cord-022353-q2k2krnm	654	2	also	also	RB
cord-022353-q2k2krnm	654	3	acts	act	VBZ
cord-022353-q2k2krnm	654	4	in	in	IN
cord-022353-q2k2krnm	654	5	a	a	DT
cord-022353-q2k2krnm	654	6	paracrine	paracrine	JJ
cord-022353-q2k2krnm	654	7	fashion	fashion	NN
cord-022353-q2k2krnm	654	8	modulating	modulate	VBG
cord-022353-q2k2krnm	654	9	the	the	DT
cord-022353-q2k2krnm	654	10	activities	activity	NNS
cord-022353-q2k2krnm	654	11	of	of	IN
cord-022353-q2k2krnm	654	12	B	b	NN
cord-022353-q2k2krnm	654	13	cells	cell	NNS
cord-022353-q2k2krnm	654	14	,	,	,
cord-022353-q2k2krnm	654	15	natural	natural	JJ
cord-022353-q2k2krnm	654	16	killer	killer	NN
cord-022353-q2k2krnm	654	17	(	(	-LRB-
cord-022353-q2k2krnm	654	18	NK	NK	NNP
cord-022353-q2k2krnm	654	19	)	)	-RRB-
cord-022353-q2k2krnm	654	20	cells	cell	NNS
cord-022353-q2k2krnm	654	21	,	,	,
cord-022353-q2k2krnm	654	22	and	and	CC
cord-022353-q2k2krnm	654	23	lymphocyte	lymphocyte	NN
cord-022353-q2k2krnm	654	24	activated	activate	VBN
cord-022353-q2k2krnm	654	25	killer	killer	NN
cord-022353-q2k2krnm	654	26	(	(	-LRB-
cord-022353-q2k2krnm	654	27	LAK	LAK	NNP
cord-022353-q2k2krnm	654	28	)	)	-RRB-
cord-022353-q2k2krnm	654	29	cells	cell	NNS
cord-022353-q2k2krnm	654	30	.	.	.
cord-022353-q2k2krnm	655	1	IL-2	IL-2	NNP
cord-022353-q2k2krnm	655	2	is	be	VBZ
cord-022353-q2k2krnm	655	3	a	a	DT
cord-022353-q2k2krnm	655	4	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	655	5	of	of	IN
cord-022353-q2k2krnm	655	6	133	133	CD
cord-022353-q2k2krnm	655	7	amino	amino	JJ
cord-022353-q2k2krnm	655	8	acids	acid	NNS
cord-022353-q2k2krnm	655	9	(	(	-LRB-
cord-022353-q2k2krnm	655	10	in	in	IN
cord-022353-q2k2krnm	655	11	humans	human	NNS
cord-022353-q2k2krnm	655	12	)	)	-RRB-
cord-022353-q2k2krnm	655	13	with	with	IN
cord-022353-q2k2krnm	655	14	63	63	CD
cord-022353-q2k2krnm	655	15	%	%	NN
cord-022353-q2k2krnm	655	16	homology	homology	NN
cord-022353-q2k2krnm	655	17	between	between	IN
cord-022353-q2k2krnm	655	18	mouse	mouse	NN
cord-022353-q2k2krnm	655	19	and	and	CC
cord-022353-q2k2krnm	655	20	human	human	NN
cord-022353-q2k2krnm	655	21	.	.	.
cord-022353-q2k2krnm	656	1	The	the	DT
cord-022353-q2k2krnm	656	2	IL-2	IL-2	NNP
cord-022353-q2k2krnm	656	3	receptor	receptor	NN
cord-022353-q2k2krnm	656	4	(	(	-LRB-
cord-022353-q2k2krnm	656	5	IL-2R	IL-2R	NNP
cord-022353-q2k2krnm	656	6	)	)	-RRB-
cord-022353-q2k2krnm	656	7	is	be	VBZ
cord-022353-q2k2krnm	656	8	a	a	DT
cord-022353-q2k2krnm	656	9	multisubunit	multisubunit	NN
cord-022353-q2k2krnm	656	10	cellular	cellular	JJ
cord-022353-q2k2krnm	656	11	receptor	receptor	NN
cord-022353-q2k2krnm	656	12	belonging	belong	VBG
cord-022353-q2k2krnm	656	13	to	to	IN
cord-022353-q2k2krnm	656	14	the	the	DT
cord-022353-q2k2krnm	656	15	class	class	NN
cord-022353-q2k2krnm	656	16	1	1	CD
cord-022353-q2k2krnm	656	17	cytokine	cytokine	NN
cord-022353-q2k2krnm	656	18	receptor	receptor	NN
cord-022353-q2k2krnm	656	19	family	family	NN
cord-022353-q2k2krnm	656	20	(	(	-LRB-
cord-022353-q2k2krnm	656	21	hematopoietin	hematopoietin	NNP
cord-022353-q2k2krnm	656	22	receptor	receptor	NNP
cord-022353-q2k2krnm	656	23	family	family	NN
cord-022353-q2k2krnm	656	24	)	)	-RRB-
cord-022353-q2k2krnm	656	25	.	.	.
cord-022353-q2k2krnm	657	1	The	the	DT
cord-022353-q2k2krnm	657	2	IL-2R	IL-2R	NNP
cord-022353-q2k2krnm	657	3	has	have	VBZ
cord-022353-q2k2krnm	657	4	a-	a-	XX
cord-022353-q2k2krnm	657	5	,	,	,
cord-022353-q2k2krnm	657	6	[	[	-LRB-
cord-022353-q2k2krnm	657	7	~-	~-	NNP
cord-022353-q2k2krnm	657	8	,	,	,
cord-022353-q2k2krnm	657	9	and	and	CC
cord-022353-q2k2krnm	657	10	y	y	NN
cord-022353-q2k2krnm	657	11	-	-	HYPH
cord-022353-q2k2krnm	657	12	chains	chain	NNS
cord-022353-q2k2krnm	657	13	.	.	.
cord-022353-q2k2krnm	658	1	[	[	-LRB-
cord-022353-q2k2krnm	658	2	3-and	3-and	NNP
cord-022353-q2k2krnm	658	3	y	y	NNP
cord-022353-q2k2krnm	658	4	-	-	HYPH
cord-022353-q2k2krnm	658	5	chains	chain	NNS
cord-022353-q2k2krnm	658	6	interact	interact	VBP
cord-022353-q2k2krnm	658	7	to	to	TO
cord-022353-q2k2krnm	658	8	transduce	transduce	VB
cord-022353-q2k2krnm	658	9	the	the	DT
cord-022353-q2k2krnm	658	10	IL-2R	IL-2R	NNP
cord-022353-q2k2krnm	658	11	signal	signal	NN
cord-022353-q2k2krnm	658	12	and	and	CC
cord-022353-q2k2krnm	658	13	the	the	DT
cord-022353-q2k2krnm	658	14	y	y	NN
cord-022353-q2k2krnm	658	15	-	-	HYPH
cord-022353-q2k2krnm	658	16	chain	chain	NN
cord-022353-q2k2krnm	658	17	is	be	VBZ
cord-022353-q2k2krnm	658	18	shared	share	VBN
cord-022353-q2k2krnm	658	19	with	with	IN
cord-022353-q2k2krnm	658	20	receptors	receptor	NNS
cord-022353-q2k2krnm	658	21	for	for	IN
cord-022353-q2k2krnm	658	22	IL-4	IL-4	NNP
cord-022353-q2k2krnm	658	23	,	,	,
cord-022353-q2k2krnm	658	24	IL-7	IL-7	NNP
cord-022353-q2k2krnm	658	25	,	,	,
cord-022353-q2k2krnm	658	26	IL-9	IL-9	NNP
cord-022353-q2k2krnm	658	27	,	,	,
cord-022353-q2k2krnm	658	28	and	and	CC
cord-022353-q2k2krnm	658	29	IL-15	IL-15	NNP
cord-022353-q2k2krnm	658	30	.	.	.
cord-022353-q2k2krnm	658	31	iii	iii	NNP
cord-022353-q2k2krnm	658	32	IgG1	igg1	NN
cord-022353-q2k2krnm	658	33	in	in	IN
cord-022353-q2k2krnm	658	34	mice	mouse	NNS
cord-022353-q2k2krnm	658	35	and	and	CC
cord-022353-q2k2krnm	658	36	is	be	VBZ
cord-022353-q2k2krnm	658	37	responsible	responsible	JJ
cord-022353-q2k2krnm	658	38	for	for	IN
cord-022353-q2k2krnm	658	39	the	the	DT
cord-022353-q2k2krnm	658	40	downstream	downstream	JJ
cord-022353-q2k2krnm	658	41	events	event	NNS
cord-022353-q2k2krnm	658	42	leading	lead	VBG
cord-022353-q2k2krnm	658	43	to	to	IN
cord-022353-q2k2krnm	658	44	differentiation	differentiation	NN
cord-022353-q2k2krnm	658	45	and	and	CC
cord-022353-q2k2krnm	658	46	activation	activation	NN
cord-022353-q2k2krnm	658	47	of	of	IN
cord-022353-q2k2krnm	658	48	TH2	TH2	NNP
cord-022353-q2k2krnm	658	49	cells	cell	NNS
cord-022353-q2k2krnm	658	50	.	.	.
cord-022353-q2k2krnm	659	1	IL-4	IL-4	NNP
cord-022353-q2k2krnm	659	2	also	also	RB
cord-022353-q2k2krnm	659	3	induces	induce	VBZ
cord-022353-q2k2krnm	659	4	expression	expression	NN
cord-022353-q2k2krnm	659	5	of	of	IN
cord-022353-q2k2krnm	659	6	adhesion	adhesion	NN
cord-022353-q2k2krnm	659	7	molecules	molecule	NNS
cord-022353-q2k2krnm	659	8	like	like	IN
cord-022353-q2k2krnm	659	9	VCAM	VCAM	NNP
cord-022353-q2k2krnm	659	10	,	,	,
cord-022353-q2k2krnm	659	11	TH2	TH2	NNP
cord-022353-q2k2krnm	659	12	cytokines	cytokine	NNS
cord-022353-q2k2krnm	659	13	such	such	JJ
cord-022353-q2k2krnm	659	14	as	as	IN
cord-022353-q2k2krnm	659	15	IL-5	IL-5	NNP
cord-022353-q2k2krnm	659	16	,	,	,
cord-022353-q2k2krnm	659	17	IL-6	IL-6	NNP
cord-022353-q2k2krnm	659	18	,	,	,
cord-022353-q2k2krnm	659	19	and	and	CC
cord-022353-q2k2krnm	659	20	IL-9	IL-9	NNP
cord-022353-q2k2krnm	659	21	and	and	CC
cord-022353-q2k2krnm	659	22	chemokines	chemokine	NNS
cord-022353-q2k2krnm	659	23	like	like	IN
cord-022353-q2k2krnm	659	24	eotaxin-1	eotaxin-1	NNP
cord-022353-q2k2krnm	659	25	and-2	and-2	NNP
cord-022353-q2k2krnm	659	26	.	.	.
cord-022353-q2k2krnm	660	1	IL-4	IL-4	NNP
cord-022353-q2k2krnm	660	2	primes	prime	NNS
cord-022353-q2k2krnm	660	3	mast	mast	NN
cord-022353-q2k2krnm	660	4	cells	cell	NNS
cord-022353-q2k2krnm	660	5	and	and	CC
cord-022353-q2k2krnm	660	6	basophils	basophil	NNS
cord-022353-q2k2krnm	660	7	leading	lead	VBG
cord-022353-q2k2krnm	660	8	to	to	IN
cord-022353-q2k2krnm	660	9	enhanced	enhanced	JJ
cord-022353-q2k2krnm	660	10	activation	activation	NN
cord-022353-q2k2krnm	660	11	during	during	IN
cord-022353-q2k2krnm	660	12	allergic	allergic	JJ
cord-022353-q2k2krnm	660	13	challenge	challenge	NN
cord-022353-q2k2krnm	660	14	(	(	-LRB-
cord-022353-q2k2krnm	660	15	Mueller	Mueller	NNP
cord-022353-q2k2krnm	660	16	et	et	NNP
cord-022353-q2k2krnm	660	17	al	al	NNP
cord-022353-q2k2krnm	660	18	.	.	.
cord-022353-q2k2krnm	660	19	2002	2002	CD
cord-022353-q2k2krnm	660	20	)	)	-RRB-
cord-022353-q2k2krnm	660	21	.	.	.
cord-022353-q2k2krnm	661	1	Homology	homology	NN
cord-022353-q2k2krnm	661	2	between	between	IN
cord-022353-q2k2krnm	661	3	mouse	mouse	NN
cord-022353-q2k2krnm	661	4	and	and	CC
cord-022353-q2k2krnm	661	5	human	human	NN
cord-022353-q2k2krnm	661	6	molecules	molecule	NNS
cord-022353-q2k2krnm	661	7	is	be	VBZ
cord-022353-q2k2krnm	661	8	low	low	JJ
cord-022353-q2k2krnm	661	9	(	(	-LRB-
cord-022353-q2k2krnm	661	10	25	25	CD
cord-022353-q2k2krnm	661	11	%	%	NN
cord-022353-q2k2krnm	661	12	)	)	-RRB-
cord-022353-q2k2krnm	661	13	and	and	CC
cord-022353-q2k2krnm	661	14	each	each	DT
cord-022353-q2k2krnm	661	15	is	be	VBZ
cord-022353-q2k2krnm	661	16	species	species	NN
cord-022353-q2k2krnm	661	17	-	-	HYPH
cord-022353-q2k2krnm	661	18	specific	specific	JJ
cord-022353-q2k2krnm	661	19	in	in	IN
cord-022353-q2k2krnm	661	20	its	-PRON-	PRP$
cord-022353-q2k2krnm	661	21	biologic	biologic	JJ
cord-022353-q2k2krnm	661	22	activity	activity	NN
cord-022353-q2k2krnm	661	23	.	.	.
cord-022353-q2k2krnm	662	1	It	-PRON-	PRP
cord-022353-q2k2krnm	662	2	induces	induce	VBZ
cord-022353-q2k2krnm	662	3	the	the	DT
cord-022353-q2k2krnm	662	4	growth	growth	NN
cord-022353-q2k2krnm	662	5	of	of	IN
cord-022353-q2k2krnm	662	6	B-1	B-1	NNP
cord-022353-q2k2krnm	662	7	progenitors	progenitor	NNS
cord-022353-q2k2krnm	662	8	and	and	CC
cord-022353-q2k2krnm	662	9	IgM	igm	NN
cord-022353-q2k2krnm	662	10	production	production	NN
cord-022353-q2k2krnm	662	11	by	by	IN
cord-022353-q2k2krnm	662	12	B-1	B-1	NNP
cord-022353-q2k2krnm	662	13	cells	cell	NNS
cord-022353-q2k2krnm	662	14	.	.	.
cord-022353-q2k2krnm	663	1	IL-5	IL-5	NNP
cord-022353-q2k2krnm	663	2	induces	induce	VBZ
cord-022353-q2k2krnm	663	3	class	class	NN
cord-022353-q2k2krnm	663	4	switch	switch	NN
cord-022353-q2k2krnm	663	5	,	,	,
cord-022353-q2k2krnm	663	6	favoring	favor	VBG
cord-022353-q2k2krnm	663	7	production	production	NN
cord-022353-q2k2krnm	663	8	of	of	IN
cord-022353-q2k2krnm	663	9	IgA	IgA	NNP
cord-022353-q2k2krnm	663	10	,	,	,
cord-022353-q2k2krnm	663	11	IgG1	IgG1	NNP
cord-022353-q2k2krnm	663	12	,	,	,
cord-022353-q2k2krnm	663	13	and	and	CC
cord-022353-q2k2krnm	664	1	IgE.	IgE.	NNP
cord-022353-q2k2krnm	664	2	On	on	IN
cord-022353-q2k2krnm	664	3	eosinophils	eosinophil	NNS
cord-022353-q2k2krnm	664	4	,	,	,
cord-022353-q2k2krnm	664	5	IL-5	IL-5	NNP
cord-022353-q2k2krnm	664	6	induces	induce	VBZ
cord-022353-q2k2krnm	664	7	IgA	IgA	NNP
cord-022353-q2k2krnm	664	8	and	and	CC
cord-022353-q2k2krnm	664	9	IgG	IgG	NNP
cord-022353-q2k2krnm	664	10	receptors	receptor	NNS
cord-022353-q2k2krnm	664	11	and	and	CC
cord-022353-q2k2krnm	664	12	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	664	13	leukotriene	leukotriene	NN
cord-022353-q2k2krnm	664	14	(	(	-LRB-
cord-022353-q2k2krnm	664	15	LT	LT	NNP
cord-022353-q2k2krnm	664	16	)	)	-RRB-
cord-022353-q2k2krnm	664	17	,	,	,
cord-022353-q2k2krnm	664	18	C4	C4	NNP
cord-022353-q2k2krnm	664	19	,	,	,
cord-022353-q2k2krnm	664	20	and	and	CC
cord-022353-q2k2krnm	664	21	PAF	PAF	NNP
cord-022353-q2k2krnm	664	22	secretion	secretion	NN
cord-022353-q2k2krnm	664	23	,	,	,
cord-022353-q2k2krnm	664	24	in	in	IN
cord-022353-q2k2krnm	664	25	addition	addition	NN
cord-022353-q2k2krnm	664	26	to	to	IN
cord-022353-q2k2krnm	664	27	inducing	induce	VBG
cord-022353-q2k2krnm	664	28	eosinophil	eosinophil	JJ
cord-022353-q2k2krnm	664	29	growth	growth	NN
cord-022353-q2k2krnm	664	30	and	and	CC
cord-022353-q2k2krnm	664	31	maturation	maturation	NN
cord-022353-q2k2krnm	664	32	.	.	.
cord-022353-q2k2krnm	665	1	The	the	DT
cord-022353-q2k2krnm	665	2	receptors	receptor	NNS
cord-022353-q2k2krnm	665	3	for	for	IN
cord-022353-q2k2krnm	665	4	IL-5	IL-5	NNP
cord-022353-q2k2krnm	665	5	consist	consist	VBP
cord-022353-q2k2krnm	665	6	of	of	IN
cord-022353-q2k2krnm	665	7	a	a	DT
cord-022353-q2k2krnm	665	8	ligand	ligand	NN
cord-022353-q2k2krnm	665	9	binding	bind	VBG
cord-022353-q2k2krnm	665	10	tx	tx	NNP
cord-022353-q2k2krnm	665	11	-	-	HYPH
cord-022353-q2k2krnm	665	12	subunit	subunit	NNP
cord-022353-q2k2krnm	665	13	and	and	CC
cord-022353-q2k2krnm	665	14	a	a	DT
cord-022353-q2k2krnm	665	15	non	non	JJ
cord-022353-q2k2krnm	665	16	-	-	JJ
cord-022353-q2k2krnm	665	17	ligand	ligand	JJ
cord-022353-q2k2krnm	665	18	binding	binding	NN
cord-022353-q2k2krnm	665	19	(	(	-LRB-
cord-022353-q2k2krnm	665	20	common	common	JJ
cord-022353-q2k2krnm	665	21	)	)	-RRB-
cord-022353-q2k2krnm	665	22	signal	signal	JJ
cord-022353-q2k2krnm	665	23	transducing	transducing	NN
cord-022353-q2k2krnm	665	24	~-subunit	~-subunit	NNP
cord-022353-q2k2krnm	665	25	that	that	WDT
cord-022353-q2k2krnm	665	26	is	be	VBZ
cord-022353-q2k2krnm	665	27	shared	share	VBN
cord-022353-q2k2krnm	665	28	by	by	IN
cord-022353-q2k2krnm	665	29	receptors	receptor	NNS
cord-022353-q2k2krnm	665	30	for	for	IN
cord-022353-q2k2krnm	665	31	IL-3	IL-3	NNP
cord-022353-q2k2krnm	665	32	and	and	CC
cord-022353-q2k2krnm	665	33	granulocyte	granulocyte	NN
cord-022353-q2k2krnm	665	34	-	-	HYPH
cord-022353-q2k2krnm	665	35	monocyte	monocyte	NNP
cord-022353-q2k2krnm	665	36	colony	colony	NN
cord-022353-q2k2krnm	665	37	-	-	HYPH
cord-022353-q2k2krnm	665	38	stimulating	stimulate	VBG
cord-022353-q2k2krnm	665	39	factor	factor	NN
cord-022353-q2k2krnm	666	1	(	(	-LRB-
cord-022353-q2k2krnm	666	2	GM	GM	NNP
cord-022353-q2k2krnm	666	3	-	-	HYPH
cord-022353-q2k2krnm	666	4	CSF	CSF	NNP
cord-022353-q2k2krnm	666	5	)	)	-RRB-
cord-022353-q2k2krnm	667	1	(	(	-LRB-
cord-022353-q2k2krnm	667	2	Sato	Sato	NNP
cord-022353-q2k2krnm	667	3	and	and	CC
cord-022353-q2k2krnm	667	4	Miyajima	Miyajima	NNP
cord-022353-q2k2krnm	667	5	1994	1994	CD
cord-022353-q2k2krnm	667	6	)	)	-RRB-
cord-022353-q2k2krnm	667	7	.	.	.
cord-022353-q2k2krnm	668	1	vi	vi	NNP
cord-022353-q2k2krnm	668	2	.	.	.
cord-022353-q2k2krnm	669	1	INTERLEUKIN-6	INTERLEUKIN-6	NNP
cord-022353-q2k2krnm	669	2	(	(	-LRB-
cord-022353-q2k2krnm	669	3	IL-6	IL-6	NNP
cord-022353-q2k2krnm	669	4	)	)	-RRB-
cord-022353-q2k2krnm	669	5	IL-6	IL-6	NNP
cord-022353-q2k2krnm	669	6	is	be	VBZ
cord-022353-q2k2krnm	669	7	secreted	secrete	VBN
cord-022353-q2k2krnm	669	8	by	by	IN
cord-022353-q2k2krnm	669	9	a	a	DT
cord-022353-q2k2krnm	669	10	wide	wide	JJ
cord-022353-q2k2krnm	669	11	variety	variety	NN
cord-022353-q2k2krnm	669	12	of	of	IN
cord-022353-q2k2krnm	669	13	cells	cell	NNS
cord-022353-q2k2krnm	669	14	including	include	VBG
cord-022353-q2k2krnm	669	15	T	t	NN
cord-022353-q2k2krnm	669	16	cells	cell	NNS
cord-022353-q2k2krnm	669	17	,	,	,
cord-022353-q2k2krnm	669	18	B	b	NN
cord-022353-q2k2krnm	669	19	cells	cell	NNS
cord-022353-q2k2krnm	669	20	,	,	,
cord-022353-q2k2krnm	669	21	monocytes	monocyte	NNS
cord-022353-q2k2krnm	669	22	,	,	,
cord-022353-q2k2krnm	669	23	fibroblasts	fibroblast	NNS
cord-022353-q2k2krnm	669	24	,	,	,
cord-022353-q2k2krnm	669	25	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	669	26	,	,	,
cord-022353-q2k2krnm	669	27	keratinocytes	keratinocyte	NNS
cord-022353-q2k2krnm	669	28	,	,	,
cord-022353-q2k2krnm	669	29	astrocytes	astrocyte	NNS
cord-022353-q2k2krnm	669	30	,	,	,
cord-022353-q2k2krnm	669	31	and	and	CC
cord-022353-q2k2krnm	669	32	endothelial	endothelial	JJ
cord-022353-q2k2krnm	669	33	cells	cell	NNS
cord-022353-q2k2krnm	669	34	.	.	.
cord-022353-q2k2krnm	670	1	It	-PRON-	PRP
cord-022353-q2k2krnm	670	2	has	have	VBZ
cord-022353-q2k2krnm	670	3	broad	broad	JJ
cord-022353-q2k2krnm	670	4	pleiotropic	pleiotropic	JJ
cord-022353-q2k2krnm	670	5	effects	effect	NNS
cord-022353-q2k2krnm	670	6	on	on	IN
cord-022353-q2k2krnm	670	7	host	host	NN
cord-022353-q2k2krnm	670	8	defense	defense	NN
cord-022353-q2k2krnm	670	9	,	,	,
cord-022353-q2k2krnm	670	10	acute	acute	JJ
cord-022353-q2k2krnm	670	11	phase	phase	NN
cord-022353-q2k2krnm	670	12	responses	response	NNS
cord-022353-q2k2krnm	670	13	,	,	,
cord-022353-q2k2krnm	670	14	immune	immune	JJ
cord-022353-q2k2krnm	670	15	responses	response	NNS
cord-022353-q2k2krnm	670	16	,	,	,
cord-022353-q2k2krnm	670	17	and	and	CC
cord-022353-q2k2krnm	670	18	hematopoiesis	hematopoiesis	NN
cord-022353-q2k2krnm	670	19	.	.	.
cord-022353-q2k2krnm	671	1	IL-6	IL-6	NNP
cord-022353-q2k2krnm	671	2	is	be	VBZ
cord-022353-q2k2krnm	671	3	classified	classify	VBN
cord-022353-q2k2krnm	671	4	as	as	IN
cord-022353-q2k2krnm	671	5	an	an	DT
cord-022353-q2k2krnm	671	6	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	671	7	cytokine	cytokine	NN
cord-022353-q2k2krnm	671	8	and	and	CC
cord-022353-q2k2krnm	671	9	based	base	VBN
cord-022353-q2k2krnm	671	10	on	on	IN
cord-022353-q2k2krnm	671	11	a	a	DT
cord-022353-q2k2krnm	671	12	helical	helical	JJ
cord-022353-q2k2krnm	671	13	cytokine	cytokine	NN
cord-022353-q2k2krnm	671	14	structure	structure	NN
cord-022353-q2k2krnm	671	15	and	and	CC
cord-022353-q2k2krnm	671	16	subunit	subunit	NN
cord-022353-q2k2krnm	671	17	makeup	makeup	NN
cord-022353-q2k2krnm	671	18	,	,	,
cord-022353-q2k2krnm	671	19	IL-6	IL-6	NNP
cord-022353-q2k2krnm	671	20	is	be	VBZ
cord-022353-q2k2krnm	671	21	the	the	DT
cord-022353-q2k2krnm	671	22	prototypic	prototypic	NNP
cord-022353-q2k2krnm	671	23	member	member	NN
cord-022353-q2k2krnm	671	24	of	of	IN
cord-022353-q2k2krnm	671	25	a	a	DT
cord-022353-q2k2krnm	671	26	family	family	NN
cord-022353-q2k2krnm	671	27	of	of	IN
cord-022353-q2k2krnm	671	28	molecules	molecule	NNS
cord-022353-q2k2krnm	671	29	that	that	WDT
cord-022353-q2k2krnm	671	30	includes	include	VBZ
cord-022353-q2k2krnm	671	31	leukemia	leukemia	NN
cord-022353-q2k2krnm	671	32	inhibitory	inhibitory	JJ
cord-022353-q2k2krnm	671	33	factor	factor	NN
cord-022353-q2k2krnm	671	34	(	(	-LRB-
cord-022353-q2k2krnm	671	35	LIF	LIF	NNP
cord-022353-q2k2krnm	671	36	)	)	-RRB-
cord-022353-q2k2krnm	671	37	,	,	,
cord-022353-q2k2krnm	671	38	oncostatin	oncostatin	NNP
cord-022353-q2k2krnm	671	39	M	M	NNP
cord-022353-q2k2krnm	671	40	(	(	-LRB-
cord-022353-q2k2krnm	671	41	OSM	OSM	NNP
cord-022353-q2k2krnm	671	42	)	)	-RRB-
cord-022353-q2k2krnm	671	43	,	,	,
cord-022353-q2k2krnm	671	44	ciliary	ciliary	NN
cord-022353-q2k2krnm	671	45	neurotrophic	neurotrophic	NN
cord-022353-q2k2krnm	671	46	factor	factor	NN
cord-022353-q2k2krnm	671	47	(	(	-LRB-
cord-022353-q2k2krnm	671	48	CNTF	CNTF	NNP
cord-022353-q2k2krnm	671	49	)	)	-RRB-
cord-022353-q2k2krnm	671	50	,	,	,
cord-022353-q2k2krnm	671	51	cardiotrophin	cardiotrophin	NNP
cord-022353-q2k2krnm	671	52	(	(	-LRB-
cord-022353-q2k2krnm	671	53	CT-1	CT-1	NNP
cord-022353-q2k2krnm	671	54	)	)	-RRB-
cord-022353-q2k2krnm	671	55	,	,	,
cord-022353-q2k2krnm	671	56	and	and	CC
cord-022353-q2k2krnm	672	1	IL-11	IL-11	NNP
cord-022353-q2k2krnm	672	2	.	.	.
cord-022353-q2k2krnm	672	3	Mouse	Mouse	NNP
cord-022353-q2k2krnm	672	4	IL-6	IL-6	NNP
cord-022353-q2k2krnm	672	5	is	be	VBZ
cord-022353-q2k2krnm	672	6	25	25	CD
cord-022353-q2k2krnm	672	7	kDa	kDa	NNS
cord-022353-q2k2krnm	672	8	and	and	CC
cord-022353-q2k2krnm	672	9	contains	contain	VBZ
cord-022353-q2k2krnm	672	10	four	four	CD
cord-022353-q2k2krnm	672	11	cysteines	cysteine	NNS
cord-022353-q2k2krnm	672	12	and	and	CC
cord-022353-q2k2krnm	672	13	contains	contain	VBZ
cord-022353-q2k2krnm	672	14	O	o	NN
cord-022353-q2k2krnm	672	15	-	-	HYPH
cord-022353-q2k2krnm	672	16	glycosylation	glycosylation	NN
cord-022353-q2k2krnm	672	17	sites	site	NNS
cord-022353-q2k2krnm	672	18	and	and	CC
cord-022353-q2k2krnm	672	19	shares	share	NNS
cord-022353-q2k2krnm	672	20	40	40	CD
cord-022353-q2k2krnm	672	21	%	%	NN
cord-022353-q2k2krnm	672	22	homology	homology	NN
cord-022353-q2k2krnm	672	23	with	with	IN
cord-022353-q2k2krnm	672	24	the	the	DT
cord-022353-q2k2krnm	672	25	human	human	JJ
cord-022353-q2k2krnm	672	26	molecule	molecule	NN
cord-022353-q2k2krnm	672	27	(	(	-LRB-
cord-022353-q2k2krnm	672	28	Van	Van	NNP
cord-022353-q2k2krnm	672	29	Snick	Snick	NNP
cord-022353-q2k2krnm	672	30	1990	1990	CD
cord-022353-q2k2krnm	672	31	)	)	-RRB-
cord-022353-q2k2krnm	672	32	.	.	.
cord-022353-q2k2krnm	673	1	The	the	DT
cord-022353-q2k2krnm	673	2	IL-6	IL-6	NNP
cord-022353-q2k2krnm	673	3	receptor	receptor	NN
cord-022353-q2k2krnm	673	4	has	have	VBZ
cord-022353-q2k2krnm	673	5	two	two	CD
cord-022353-q2k2krnm	673	6	subunits	subunit	NNS
cord-022353-q2k2krnm	673	7	,	,	,
cord-022353-q2k2krnm	673	8	a	a	DT
cord-022353-q2k2krnm	673	9	nonsignal	nonsignal	JJ
cord-022353-q2k2krnm	673	10	transducing	transduce	VBG
cord-022353-q2k2krnm	673	11	subunit	subunit	NN
cord-022353-q2k2krnm	673	12	binding	bind	VBG
cord-022353-q2k2krnm	673	13	with	with	IN
cord-022353-q2k2krnm	673	14	low	low	JJ
cord-022353-q2k2krnm	673	15	affinity	affinity	NN
cord-022353-q2k2krnm	673	16	(	(	-LRB-
cord-022353-q2k2krnm	673	17	~-subunit	~-subunit	NNP
cord-022353-q2k2krnm	673	18	)	)	-RRB-
cord-022353-q2k2krnm	673	19	,	,	,
cord-022353-q2k2krnm	673	20	and	and	CC
cord-022353-q2k2krnm	673	21	a	a	DT
cord-022353-q2k2krnm	673	22	signal	signal	NN
cord-022353-q2k2krnm	673	23	transducing	transducing	NN
cord-022353-q2k2krnm	673	24	subunit	subunit	NN
cord-022353-q2k2krnm	673	25	(	(	-LRB-
cord-022353-q2k2krnm	673	26	~-subunit	~-subunit	NNP
cord-022353-q2k2krnm	673	27	)	)	-RRB-
cord-022353-q2k2krnm	673	28	that	that	WDT
cord-022353-q2k2krnm	673	29	does	do	VBZ
cord-022353-q2k2krnm	673	30	not	not	RB
cord-022353-q2k2krnm	673	31	bind	bind	VB
cord-022353-q2k2krnm	673	32	IL-6	IL-6	NNP
cord-022353-q2k2krnm	673	33	by	by	IN
cord-022353-q2k2krnm	673	34	itself	-PRON-	PRP
cord-022353-q2k2krnm	673	35	but	but	CC
cord-022353-q2k2krnm	673	36	participates	participate	VBZ
cord-022353-q2k2krnm	673	37	in	in	IN
cord-022353-q2k2krnm	673	38	high	high	JJ
cord-022353-q2k2krnm	673	39	-	-	HYPH
cord-022353-q2k2krnm	673	40	affinity	affinity	NN
cord-022353-q2k2krnm	673	41	binding	binding	NN
cord-022353-q2k2krnm	673	42	.	.	.
cord-022353-q2k2krnm	674	1	The	the	DT
cord-022353-q2k2krnm	674	2	soluble	soluble	JJ
cord-022353-q2k2krnm	674	3	IL-6R~	il-6r~	CD
cord-022353-q2k2krnm	674	4	chain	chain	NN
cord-022353-q2k2krnm	674	5	binds	bind	VBZ
cord-022353-q2k2krnm	674	6	IL-6	IL-6	NNP
cord-022353-q2k2krnm	674	7	and	and	CC
cord-022353-q2k2krnm	674	8	the	the	DT
cord-022353-q2k2krnm	674	9	complex	complex	NN
cord-022353-q2k2krnm	674	10	induces	induce	VBZ
cord-022353-q2k2krnm	674	11	expression	expression	NN
cord-022353-q2k2krnm	674	12	of	of	IN
cord-022353-q2k2krnm	674	13	MCP-1	MCP-1	NNP
cord-022353-q2k2krnm	674	14	,	,	,
cord-022353-q2k2krnm	674	15	which	which	WDT
cord-022353-q2k2krnm	674	16	attracts	attract	VBZ
cord-022353-q2k2krnm	674	17	monocytes	monocyte	NNS
cord-022353-q2k2krnm	674	18	into	into	IN
cord-022353-q2k2krnm	674	19	areas	area	NNS
cord-022353-q2k2krnm	674	20	of	of	IN
cord-022353-q2k2krnm	674	21	inflammation	inflammation	NN
cord-022353-q2k2krnm	675	1	(	(	-LRB-
cord-022353-q2k2krnm	675	2	Kaplanski	Kaplanski	NNP
cord-022353-q2k2krnm	675	3	et	et	NNP
cord-022353-q2k2krnm	675	4	al	al	NNP
cord-022353-q2k2krnm	675	5	.	.	NNP
cord-022353-q2k2krnm	675	6	2003	2003	CD
cord-022353-q2k2krnm	675	7	)	)	-RRB-
cord-022353-q2k2krnm	675	8	.	.	.
cord-022353-q2k2krnm	676	1	vii	vii	NN
cord-022353-q2k2krnm	676	2	.	.	.
cord-022353-q2k2krnm	676	3	INTERLEUKIN-7	interleukin-7	NN
cord-022353-q2k2krnm	676	4	(	(	-LRB-
cord-022353-q2k2krnm	676	5	IL-7	IL-7	NNP
cord-022353-q2k2krnm	676	6	)	)	-RRB-
cord-022353-q2k2krnm	676	7	IL-7	IL-7	NNP
cord-022353-q2k2krnm	676	8	,	,	,
cord-022353-q2k2krnm	676	9	previously	previously	RB
cord-022353-q2k2krnm	676	10	called	call	VBN
cord-022353-q2k2krnm	676	11	lymphopoietin-1	lymphopoietin-1	NNP
cord-022353-q2k2krnm	676	12	,	,	,
cord-022353-q2k2krnm	676	13	is	be	VBZ
cord-022353-q2k2krnm	676	14	expressed	express	VBN
cord-022353-q2k2krnm	676	15	by	by	IN
cord-022353-q2k2krnm	676	16	stromal	stromal	JJ
cord-022353-q2k2krnm	676	17	cells	cell	NNS
cord-022353-q2k2krnm	676	18	,	,	,
cord-022353-q2k2krnm	676	19	especially	especially	RB
cord-022353-q2k2krnm	676	20	in	in	IN
cord-022353-q2k2krnm	676	21	the	the	DT
cord-022353-q2k2krnm	676	22	bone	bone	NN
cord-022353-q2k2krnm	676	23	marrow	marrow	NN
cord-022353-q2k2krnm	676	24	and	and	CC
cord-022353-q2k2krnm	676	25	thymus	thymus	NN
cord-022353-q2k2krnm	676	26	,	,	,
cord-022353-q2k2krnm	676	27	where	where	WRB
cord-022353-q2k2krnm	676	28	it	-PRON-	PRP
cord-022353-q2k2krnm	676	29	promotes	promote	VBZ
cord-022353-q2k2krnm	676	30	thymopoiesis	thymopoiesis	NN
cord-022353-q2k2krnm	676	31	of	of	IN
cord-022353-q2k2krnm	676	32	T	T	NNP
cord-022353-q2k2krnm	676	33	cells	cell	NNS
cord-022353-q2k2krnm	676	34	and	and	CC
cord-022353-q2k2krnm	676	35	the	the	DT
cord-022353-q2k2krnm	676	36	differentiation	differentiation	NN
cord-022353-q2k2krnm	676	37	of	of	IN
cord-022353-q2k2krnm	676	38	pro	pro	JJ
cord-022353-q2k2krnm	676	39	-	-	JJ
cord-022353-q2k2krnm	676	40	B	b	JJ
cord-022353-q2k2krnm	676	41	cells	cell	NNS
cord-022353-q2k2krnm	676	42	into	into	IN
cord-022353-q2k2krnm	676	43	pre	pre	JJ
cord-022353-q2k2krnm	676	44	-	-	JJ
cord-022353-q2k2krnm	676	45	B	b	NN
cord-022353-q2k2krnm	676	46	cells	cell	NNS
cord-022353-q2k2krnm	677	1	(	(	-LRB-
cord-022353-q2k2krnm	677	2	Aspinall	Aspinall	NNP
cord-022353-q2k2krnm	677	3	et	et	FW
cord-022353-q2k2krnm	677	4	al	al	NNP
cord-022353-q2k2krnm	677	5	.	.	.
cord-022353-q2k2krnm	678	1	2004	2004	CD
cord-022353-q2k2krnm	678	2	;	;	:
cord-022353-q2k2krnm	678	3	Goldsby	Goldsby	NNP
cord-022353-q2k2krnm	678	4	et	et	NNP
cord-022353-q2k2krnm	678	5	al	al	NNP
cord-022353-q2k2krnm	678	6	.	.	NNP
cord-022353-q2k2krnm	678	7	2003	2003	CD
cord-022353-q2k2krnm	678	8	)	)	-RRB-
cord-022353-q2k2krnm	678	9	.	.	.
cord-022353-q2k2krnm	679	1	Mouse	Mouse	NNP
cord-022353-q2k2krnm	679	2	IL-7	IL-7	NNP
cord-022353-q2k2krnm	679	3	has	have	VBZ
cord-022353-q2k2krnm	679	4	65	65	CD
cord-022353-q2k2krnm	679	5	%	%	NN
cord-022353-q2k2krnm	679	6	amino	amino	NN
cord-022353-q2k2krnm	679	7	acid	acid	NN
cord-022353-q2k2krnm	679	8	sequence	sequence	NN
cord-022353-q2k2krnm	679	9	homology	homology	NN
cord-022353-q2k2krnm	679	10	with	with	IN
cord-022353-q2k2krnm	679	11	human	human	NN
cord-022353-q2k2krnm	680	1	IL-7	IL-7	NNP
cord-022353-q2k2krnm	681	1	and	and	CC
cord-022353-q2k2krnm	681	2	both	both	DT
cord-022353-q2k2krnm	681	3	proteins	protein	NNS
cord-022353-q2k2krnm	681	4	exhibit	exhibit	VBP
cord-022353-q2k2krnm	681	5	cross	cross	JJ
cord-022353-q2k2krnm	681	6	-	-	JJ
cord-022353-q2k2krnm	681	7	species	species	JJ
cord-022353-q2k2krnm	681	8	activity	activity	NN
cord-022353-q2k2krnm	681	9	.	.	.
cord-022353-q2k2krnm	682	1	viii	viii	NNP
cord-022353-q2k2krnm	682	2	.	.	.
cord-022353-q2k2krnm	683	1	INTERLEUKIN-8	INTERLEUKIN-8	NNP
cord-022353-q2k2krnm	684	1	(	(	-LRB-
cord-022353-q2k2krnm	684	2	IL-8	IL-8	NNP
cord-022353-q2k2krnm	684	3	)	)	-RRB-
cord-022353-q2k2krnm	684	4	IL-8	IL-8	NNP
cord-022353-q2k2krnm	684	5	is	be	VBZ
cord-022353-q2k2krnm	684	6	not	not	RB
cord-022353-q2k2krnm	684	7	expressed	express	VBN
cord-022353-q2k2krnm	684	8	in	in	IN
cord-022353-q2k2krnm	684	9	the	the	DT
cord-022353-q2k2krnm	684	10	mouse	mouse	NN
cord-022353-q2k2krnm	684	11	;	;	:
cord-022353-q2k2krnm	684	12	however	however	RB
cord-022353-q2k2krnm	684	13	,	,	,
cord-022353-q2k2krnm	684	14	another	another	DT
cord-022353-q2k2krnm	684	15	protein	protein	NN
cord-022353-q2k2krnm	684	16	,	,	,
cord-022353-q2k2krnm	684	17	KC	KC	NNP
cord-022353-q2k2krnm	684	18	,	,	,
cord-022353-q2k2krnm	684	19	is	be	VBZ
cord-022353-q2k2krnm	684	20	secreted	secrete	VBN
cord-022353-q2k2krnm	684	21	and	and	CC
cord-022353-q2k2krnm	684	22	has	have	VBZ
cord-022353-q2k2krnm	684	23	many	many	JJ
cord-022353-q2k2krnm	684	24	properties	property	NNS
cord-022353-q2k2krnm	684	25	of	of	IN
cord-022353-q2k2krnm	684	26	the	the	DT
cord-022353-q2k2krnm	684	27	human	human	JJ
cord-022353-q2k2krnm	684	28	chemokine	chemokine	NN
cord-022353-q2k2krnm	684	29	,	,	,
cord-022353-q2k2krnm	684	30	GRO	GRO	NNP
cord-022353-q2k2krnm	684	31	,	,	,
cord-022353-q2k2krnm	684	32	which	which	WDT
cord-022353-q2k2krnm	684	33	is	be	VBZ
cord-022353-q2k2krnm	684	34	known	know	VBN
cord-022353-q2k2krnm	684	35	to	to	TO
cord-022353-q2k2krnm	684	36	bind	bind	VB
cord-022353-q2k2krnm	684	37	the	the	DT
cord-022353-q2k2krnm	684	38	IL-8	IL-8	NNP
cord-022353-q2k2krnm	684	39	receptor	receptor	NN
cord-022353-q2k2krnm	684	40	(	(	-LRB-
cord-022353-q2k2krnm	684	41	see	see	VB
cord-022353-q2k2krnm	684	42	the	the	DT
cord-022353-q2k2krnm	684	43	"	"	``
cord-022353-q2k2krnm	684	44	Cytokines	Cytokines	NNPS
cord-022353-q2k2krnm	684	45	and	and	CC
cord-022353-q2k2krnm	684	46	Chemokines	Chemokines	NNPS
cord-022353-q2k2krnm	684	47	"	"	''
cord-022353-q2k2krnm	684	48	section	section	NN
cord-022353-q2k2krnm	684	49	)	)	-RRB-
cord-022353-q2k2krnm	684	50	.	.	.
cord-022353-q2k2krnm	685	1	ix	ix	NNP
cord-022353-q2k2krnm	685	2	.	.	.
cord-022353-q2k2krnm	686	1	INrElCLEVlClN	INrElCLEVlClN	``
cord-022353-q2k2krnm	686	2	-	-	HYPH
cord-022353-q2k2krnm	686	3	IO	IO	NNP
cord-022353-q2k2krnm	686	4	(	(	-LRB-
cord-022353-q2k2krnm	686	5	IL	IL	NNP
cord-022353-q2k2krnm	686	6	-	-	HYPH
cord-022353-q2k2krnm	686	7	IO	IO	NNP
cord-022353-q2k2krnm	686	8	)	)	-RRB-
cord-022353-q2k2krnm	686	9	IL-10	IL-10	NNP
cord-022353-q2k2krnm	686	10	is	be	VBZ
cord-022353-q2k2krnm	686	11	the	the	DT
cord-022353-q2k2krnm	686	12	prototypic	prototypic	NNP
cord-022353-q2k2krnm	686	13	member	member	NN
cord-022353-q2k2krnm	686	14	of	of	IN
cord-022353-q2k2krnm	686	15	the	the	DT
cord-022353-q2k2krnm	686	16	IL-10	IL-10	NNP
cord-022353-q2k2krnm	686	17	cytokine	cytokine	NN
cord-022353-q2k2krnm	686	18	family	family	NN
cord-022353-q2k2krnm	686	19	comprising	comprise	VBG
cord-022353-q2k2krnm	686	20	ILl0	ILl0	NNP
cord-022353-q2k2krnm	686	21	,	,	,
cord-022353-q2k2krnm	686	22	IL-19	IL-19	NNP
cord-022353-q2k2krnm	686	23	,	,	,
cord-022353-q2k2krnm	686	24	IL-20	IL-20	NNP
cord-022353-q2k2krnm	686	25	,	,	,
cord-022353-q2k2krnm	686	26	IL-22	IL-22	NNP
cord-022353-q2k2krnm	686	27	,	,	,
cord-022353-q2k2krnm	686	28	IL-24	IL-24	NNP
cord-022353-q2k2krnm	686	29	(	(	-LRB-
cord-022353-q2k2krnm	686	30	FISP	FISP	NNP
cord-022353-q2k2krnm	686	31	)	)	-RRB-
cord-022353-q2k2krnm	686	32	,	,	,
cord-022353-q2k2krnm	686	33	and	and	CC
cord-022353-q2k2krnm	686	34	IL-26	IL-26	NNP
cord-022353-q2k2krnm	686	35	.	.	.
cord-022353-q2k2krnm	686	36	IL-10	IL-10	NNP
cord-022353-q2k2krnm	686	37	is	be	VBZ
cord-022353-q2k2krnm	686	38	a	a	DT
cord-022353-q2k2krnm	686	39	178	178	CD
cord-022353-q2k2krnm	686	40	amino	amino	NN
cord-022353-q2k2krnm	686	41	acid	acid	NN
cord-022353-q2k2krnm	686	42	protein	protein	NN
cord-022353-q2k2krnm	686	43	with	with	IN
cord-022353-q2k2krnm	686	44	an	an	DT
cord-022353-q2k2krnm	686	45	18	18	CD
cord-022353-q2k2krnm	686	46	amino	amino	NN
cord-022353-q2k2krnm	686	47	acid	acid	NN
cord-022353-q2k2krnm	686	48	signaling	signal	VBG
cord-022353-q2k2krnm	686	49	sequence	sequence	NN
cord-022353-q2k2krnm	686	50	.	.	.
cord-022353-q2k2krnm	687	1	Both	both	DT
cord-022353-q2k2krnm	687	2	mouse	mouse	NN
cord-022353-q2k2krnm	687	3	and	and	CC
cord-022353-q2k2krnm	687	4	human	human	NN
cord-022353-q2k2krnm	687	5	IL-10s	IL-10s	NNP
cord-022353-q2k2krnm	687	6	have	have	VBP
cord-022353-q2k2krnm	687	7	two	two	CD
cord-022353-q2k2krnm	687	8	intrachain	intrachain	NN
cord-022353-q2k2krnm	687	9	disulfide	disulfide	NN
cord-022353-q2k2krnm	687	10	bonds	bond	NNS
cord-022353-q2k2krnm	687	11	and	and	CC
cord-022353-q2k2krnm	687	12	form	form	VB
cord-022353-q2k2krnm	687	13	non	non	JJ
cord-022353-q2k2krnm	687	14	-	-	JJ
cord-022353-q2k2krnm	687	15	disulfide	disulfide	JJ
cord-022353-q2k2krnm	687	16	linked	link	VBN
cord-022353-q2k2krnm	687	17	homodimers	homodimer	NNS
cord-022353-q2k2krnm	687	18	.	.	.
cord-022353-q2k2krnm	688	1	Mouse	mouse	NN
cord-022353-q2k2krnm	688	2	and	and	CC
cord-022353-q2k2krnm	688	3	human	human	JJ
cord-022353-q2k2krnm	688	4	IL-10	IL-10	NNP
cord-022353-q2k2krnm	688	5	are	be	VBP
cord-022353-q2k2krnm	688	6	72	72	CD
cord-022353-q2k2krnm	688	7	%	%	NN
cord-022353-q2k2krnm	688	8	homologous	homologous	JJ
cord-022353-q2k2krnm	688	9	.	.	.
cord-022353-q2k2krnm	689	1	IL-10	IL-10	NNP
cord-022353-q2k2krnm	689	2	is	be	VBZ
cord-022353-q2k2krnm	689	3	a	a	DT
cord-022353-q2k2krnm	689	4	TH2	TH2	NNP
cord-022353-q2k2krnm	689	5	cytokine	cytokine	NN
cord-022353-q2k2krnm	689	6	,	,	,
cord-022353-q2k2krnm	689	7	which	which	WDT
cord-022353-q2k2krnm	689	8	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	689	9	IFN	IFN	NNP
cord-022353-q2k2krnm	689	10	-	-	HYPH
cord-022353-q2k2krnm	689	11	y	y	NNP
cord-022353-q2k2krnm	689	12	and	and	CC
cord-022353-q2k2krnm	689	13	GM	GM	NNP
cord-022353-q2k2krnm	689	14	-	-	HYPH
cord-022353-q2k2krnm	689	15	CSF	csf	NN
cord-022353-q2k2krnm	689	16	production	production	NN
cord-022353-q2k2krnm	689	17	by	by	IN
cord-022353-q2k2krnm	689	18	TH1	th1	NN
cord-022353-q2k2krnm	689	19	cells	cell	NNS
cord-022353-q2k2krnm	689	20	.	.	.
cord-022353-q2k2krnm	690	1	Additionally	additionally	RB
cord-022353-q2k2krnm	690	2	it	-PRON-	PRP
cord-022353-q2k2krnm	690	3	induces	induce	VBZ
cord-022353-q2k2krnm	690	4	CD8	CD8	NNP
cord-022353-q2k2krnm	690	5	+	+	CC
cord-022353-q2k2krnm	690	6	T	t	NN
cord-022353-q2k2krnm	690	7	-	-	HYPH
cord-022353-q2k2krnm	690	8	cell	cell	NN
cord-022353-q2k2krnm	690	9	chemotaxis	chemotaxis	NN
cord-022353-q2k2krnm	690	10	,	,	,
cord-022353-q2k2krnm	690	11	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	690	12	T	t	NN
cord-022353-q2k2krnm	690	13	-	-	HYPH
cord-022353-q2k2krnm	690	14	cell	cell	NN
cord-022353-q2k2krnm	690	15	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	690	16	,	,	,
cord-022353-q2k2krnm	690	17	participates	participate	VBZ
cord-022353-q2k2krnm	690	18	in	in	IN
cord-022353-q2k2krnm	690	19	IgA	IgA	NNP
cord-022353-q2k2krnm	690	20	class	class	NNP
cord-022353-q2k2krnm	690	21	switch	switch	NN
cord-022353-q2k2krnm	690	22	in	in	RP
cord-022353-q2k2krnm	690	23	B	b	NN
cord-022353-q2k2krnm	690	24	cells	cell	NNS
cord-022353-q2k2krnm	690	25	,	,	,
cord-022353-q2k2krnm	690	26	induces	induce	VBZ
cord-022353-q2k2krnm	690	27	histamine	histamine	NN
cord-022353-q2k2krnm	690	28	release	release	NN
cord-022353-q2k2krnm	690	29	from	from	IN
cord-022353-q2k2krnm	690	30	mast	mast	NN
cord-022353-q2k2krnm	690	31	cells	cell	NNS
cord-022353-q2k2krnm	690	32	,	,	,
cord-022353-q2k2krnm	690	33	and	and	CC
cord-022353-q2k2krnm	690	34	promotes	promote	VBZ
cord-022353-q2k2krnm	690	35	TNF	TNF	NNP
cord-022353-q2k2krnm	690	36	-	-	HYPH
cord-022353-q2k2krnm	690	37	tx	tx	NNP
cord-022353-q2k2krnm	690	38	and	and	CC
cord-022353-q2k2krnm	690	39	GM	GM	NNP
cord-022353-q2k2krnm	690	40	-	-	HYPH
cord-022353-q2k2krnm	690	41	CSF	csf	NN
cord-022353-q2k2krnm	690	42	production	production	NN
cord-022353-q2k2krnm	690	43	by	by	IN
cord-022353-q2k2krnm	690	44	NK	NK	NNP
cord-022353-q2k2krnm	690	45	cells	cell	NNS
cord-022353-q2k2krnm	690	46	.	.	.
cord-022353-q2k2krnm	691	1	IL-10	IL-10	NNP
cord-022353-q2k2krnm	691	2	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	691	3	secretion	secretion	NN
cord-022353-q2k2krnm	691	4	of	of	IN
cord-022353-q2k2krnm	691	5	the	the	DT
cord-022353-q2k2krnm	691	6	neutrophil	neutrophil	NN
cord-022353-q2k2krnm	691	7	chemokines	chemokine	NNS
cord-022353-q2k2krnm	691	8	MIP	MIP	NNP
cord-022353-q2k2krnm	691	9	-	-	HYPH
cord-022353-q2k2krnm	691	10	lt~	lt~	NNP
cord-022353-q2k2krnm	691	11	and	and	CC
cord-022353-q2k2krnm	691	12	MIP	MIP	NNP
cord-022353-q2k2krnm	691	13	-	-	HYPH
cord-022353-q2k2krnm	691	14	I~	I~	NNP
cord-022353-q2k2krnm	691	15	and	and	CC
cord-022353-q2k2krnm	691	16	blocks	block	VBZ
cord-022353-q2k2krnm	691	17	production	production	NN
cord-022353-q2k2krnm	691	18	of	of	IN
cord-022353-q2k2krnm	691	19	IL-1~	IL-1~	NNP
cord-022353-q2k2krnm	691	20	and	and	CC
cord-022353-q2k2krnm	691	21	TNF	TNF	NNP
cord-022353-q2k2krnm	691	22	-	-	HYPH
cord-022353-q2k2krnm	691	23	ct	ct	NNP
cord-022353-q2k2krnm	691	24	by	by	IN
cord-022353-q2k2krnm	691	25	neutrophils	neutrophil	NNS
cord-022353-q2k2krnm	691	26	.	.	.
cord-022353-q2k2krnm	692	1	It	-PRON-	PRP
cord-022353-q2k2krnm	692	2	is	be	VBZ
cord-022353-q2k2krnm	692	3	immunosuppressive	immunosuppressive	JJ
cord-022353-q2k2krnm	692	4	to	to	IN
cord-022353-q2k2krnm	692	5	dendritic	dendritic	JJ
cord-022353-q2k2krnm	692	6	cells	cell	NNS
cord-022353-q2k2krnm	692	7	and	and	CC
cord-022353-q2k2krnm	692	8	induces	induce	VBZ
cord-022353-q2k2krnm	692	9	the	the	DT
cord-022353-q2k2krnm	692	10	differentiation	differentiation	NN
cord-022353-q2k2krnm	692	11	of	of	IN
cord-022353-q2k2krnm	692	12	a	a	DT
cord-022353-q2k2krnm	692	13	subset	subset	NN
cord-022353-q2k2krnm	692	14	of	of	IN
cord-022353-q2k2krnm	692	15	regulatory	regulatory	JJ
cord-022353-q2k2krnm	692	16	CD4	CD4	NNP
cord-022353-q2k2krnm	692	17	+	+	CC
cord-022353-q2k2krnm	692	18	T	t	NN
cord-022353-q2k2krnm	692	19	cells	cell	NNS
cord-022353-q2k2krnm	692	20	(	(	-LRB-
cord-022353-q2k2krnm	692	21	Trl	trl	NN
cord-022353-q2k2krnm	692	22	)	)	-RRB-
cord-022353-q2k2krnm	692	23	(	(	-LRB-
cord-022353-q2k2krnm	692	24	Grouz	Grouz	NNP
cord-022353-q2k2krnm	692	25	and	and	CC
cord-022353-q2k2krnm	692	26	Cottrez	Cottrez	NNP
cord-022353-q2k2krnm	692	27	2003	2003	CD
cord-022353-q2k2krnm	692	28	;	;	:
cord-022353-q2k2krnm	692	29	Morel	Morel	NNP
cord-022353-q2k2krnm	692	30	et	et	NNP
cord-022353-q2k2krnm	692	31	al	al	NNP
cord-022353-q2k2krnm	692	32	.	.	.
cord-022353-q2k2krnm	692	33	1997	1997	CD
cord-022353-q2k2krnm	692	34	)	)	-RRB-
cord-022353-q2k2krnm	692	35	.	.	.
cord-022353-q2k2krnm	693	1	x.	x.	NNP
cord-022353-q2k2krnm	693	2	IL-11	IL-11	NNP
cord-022353-q2k2krnm	693	3	,	,	,
cord-022353-q2k2krnm	693	4	also	also	RB
cord-022353-q2k2krnm	693	5	known	know	VBN
cord-022353-q2k2krnm	693	6	as	as	IN
cord-022353-q2k2krnm	693	7	adipogenesis	adipogenesis	NN
cord-022353-q2k2krnm	693	8	inhibitory	inhibitory	JJ
cord-022353-q2k2krnm	693	9	factor	factor	NN
cord-022353-q2k2krnm	693	10	(	(	-LRB-
cord-022353-q2k2krnm	693	11	AGIF	AGIF	NNP
cord-022353-q2k2krnm	693	12	)	)	-RRB-
cord-022353-q2k2krnm	693	13	,	,	,
cord-022353-q2k2krnm	693	14	is	be	VBZ
cord-022353-q2k2krnm	693	15	a	a	DT
cord-022353-q2k2krnm	693	16	pleiotropic	pleiotropic	JJ
cord-022353-q2k2krnm	693	17	cytokine	cytokine	NN
cord-022353-q2k2krnm	693	18	with	with	IN
cord-022353-q2k2krnm	693	19	effects	effect	NNS
cord-022353-q2k2krnm	693	20	that	that	WDT
cord-022353-q2k2krnm	693	21	overlap	overlap	VBP
cord-022353-q2k2krnm	693	22	that	that	DT
cord-022353-q2k2krnm	693	23	of	of	IN
cord-022353-q2k2krnm	693	24	IL-6	IL-6	NNP
cord-022353-q2k2krnm	693	25	.	.	.
cord-022353-q2k2krnm	693	26	IL-11	IL-11	NNP
cord-022353-q2k2krnm	693	27	is	be	VBZ
cord-022353-q2k2krnm	693	28	a	a	DT
cord-022353-q2k2krnm	693	29	member	member	NN
cord-022353-q2k2krnm	693	30	of	of	IN
cord-022353-q2k2krnm	693	31	the	the	DT
cord-022353-q2k2krnm	693	32	IL-6	IL-6	NNP
cord-022353-q2k2krnm	693	33	cytokine	cytokine	NN
cord-022353-q2k2krnm	693	34	family	family	NN
cord-022353-q2k2krnm	693	35	and	and	CC
cord-022353-q2k2krnm	693	36	as	as	IN
cord-022353-q2k2krnm	693	37	such	such	JJ
cord-022353-q2k2krnm	693	38	has	have	VBZ
cord-022353-q2k2krnm	693	39	a	a	DT
cord-022353-q2k2krnm	693	40	four	four	CD
cord-022353-q2k2krnm	693	41	-	-	HYPH
cord-022353-q2k2krnm	693	42	helix	helix	NN
cord-022353-q2k2krnm	693	43	bundle	bundle	NN
cord-022353-q2k2krnm	693	44	fold	fold	NN
cord-022353-q2k2krnm	693	45	motif	motif	NN
cord-022353-q2k2krnm	693	46	.	.	.
cord-022353-q2k2krnm	694	1	It	-PRON-	PRP
cord-022353-q2k2krnm	694	2	binds	bind	VBZ
cord-022353-q2k2krnm	694	3	to	to	IN
cord-022353-q2k2krnm	694	4	the	the	DT
cord-022353-q2k2krnm	694	5	multimeric	multimeric	JJ
cord-022353-q2k2krnm	694	6	IL-11	IL-11	NNP
cord-022353-q2k2krnm	694	7	receptor	receptor	NN
cord-022353-q2k2krnm	694	8	that	that	WDT
cord-022353-q2k2krnm	694	9	shares	share	VBZ
cord-022353-q2k2krnm	694	10	the	the	DT
cord-022353-q2k2krnm	694	11	promiscuous	promiscuous	JJ
cord-022353-q2k2krnm	694	12	gpl30	gpl30	NNPS
cord-022353-q2k2krnm	694	13	signaling	signal	VBG
cord-022353-q2k2krnm	694	14	~-subunit	~-subunit	NNS
cord-022353-q2k2krnm	694	15	with	with	IN
cord-022353-q2k2krnm	694	16	other	other	JJ
cord-022353-q2k2krnm	694	17	receptors	receptor	NNS
cord-022353-q2k2krnm	694	18	in	in	IN
cord-022353-q2k2krnm	694	19	this	this	DT
cord-022353-q2k2krnm	694	20	family	family	NN
cord-022353-q2k2krnm	694	21	.	.	.
cord-022353-q2k2krnm	695	1	The	the	DT
cord-022353-q2k2krnm	695	2	IL-11R	IL-11R	NNP
cord-022353-q2k2krnm	695	3	~	~	CD
cord-022353-q2k2krnm	695	4	chain	chain	NN
cord-022353-q2k2krnm	695	5	is	be	VBZ
cord-022353-q2k2krnm	695	6	unique	unique	JJ
cord-022353-q2k2krnm	695	7	and	and	CC
cord-022353-q2k2krnm	695	8	binds	bind	VBZ
cord-022353-q2k2krnm	695	9	IL-11	IL-11	NNP
cord-022353-q2k2krnm	695	10	but	but	CC
cord-022353-q2k2krnm	695	11	does	do	VBZ
cord-022353-q2k2krnm	695	12	not	not	RB
cord-022353-q2k2krnm	695	13	have	have	VB
cord-022353-q2k2krnm	695	14	a	a	DT
cord-022353-q2k2krnm	695	15	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	695	16	domain	domain	NN
cord-022353-q2k2krnm	695	17	;	;	:
cord-022353-q2k2krnm	695	18	instead	instead	RB
cord-022353-q2k2krnm	695	19	binding	bind	VBG
cord-022353-q2k2krnm	695	20	leads	lead	NNS
cord-022353-q2k2krnm	695	21	to	to	IN
cord-022353-q2k2krnm	695	22	homodimerization	homodimerization	NN
cord-022353-q2k2krnm	695	23	of	of	IN
cord-022353-q2k2krnm	695	24	the	the	DT
cord-022353-q2k2krnm	695	25	~-chain	~-chain	XX
cord-022353-q2k2krnm	696	1	that	that	DT
cord-022353-q2k2krnm	696	2	activates	activate	VBZ
cord-022353-q2k2krnm	696	3	the	the	DT
cord-022353-q2k2krnm	696	4	Janus	Janus	NNP
cord-022353-q2k2krnm	696	5	kinases	kinase	NNS
cord-022353-q2k2krnm	696	6	.	.	.
cord-022353-q2k2krnm	697	1	IL-11	IL-11	NNP
cord-022353-q2k2krnm	697	2	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	697	3	proliferation	proliferation	NN
cord-022353-q2k2krnm	697	4	and	and	CC
cord-022353-q2k2krnm	697	5	differentiation	differentiation	NN
cord-022353-q2k2krnm	697	6	of	of	IN
cord-022353-q2k2krnm	697	7	monocytes	monocyte	NNS
cord-022353-q2k2krnm	697	8	and	and	CC
cord-022353-q2k2krnm	697	9	megakaryocytes	megakaryocyte	NNS
cord-022353-q2k2krnm	697	10	causing	cause	VBG
cord-022353-q2k2krnm	697	11	thrombopoiesis	thrombopoiesis	NNP
cord-022353-q2k2krnm	697	12	.	.	.
cord-022353-q2k2krnm	698	1	It	-PRON-	PRP
cord-022353-q2k2krnm	698	2	also	also	RB
cord-022353-q2k2krnm	698	3	activates	activate	VBZ
cord-022353-q2k2krnm	698	4	osteoclasts	osteoclast	NNS
cord-022353-q2k2krnm	698	5	and	and	CC
cord-022353-q2k2krnm	698	6	enhances	enhance	VBZ
cord-022353-q2k2krnm	698	7	bone	bone	NN
cord-022353-q2k2krnm	698	8	resorption	resorption	NN
cord-022353-q2k2krnm	698	9	,	,	,
cord-022353-q2k2krnm	698	10	decreases	decrease	VBZ
cord-022353-q2k2krnm	698	11	new	new	JJ
cord-022353-q2k2krnm	698	12	bone	bone	NN
cord-022353-q2k2krnm	698	13	formation	formation	NN
cord-022353-q2k2krnm	698	14	,	,	,
cord-022353-q2k2krnm	698	15	and	and	CC
cord-022353-q2k2krnm	698	16	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	698	17	chondrocyte	chondrocyte	NNP
cord-022353-q2k2krnm	698	18	and	and	CC
cord-022353-q2k2krnm	698	19	synoviocyte	synoviocyte	NNP
cord-022353-q2k2krnm	698	20	production	production	NN
cord-022353-q2k2krnm	698	21	.	.	.
cord-022353-q2k2krnm	699	1	IL-11	IL-11	NNP
cord-022353-q2k2krnm	699	2	protects	protect	VBZ
cord-022353-q2k2krnm	699	3	small	small	JJ
cord-022353-q2k2krnm	699	4	intestinal	intestinal	JJ
cord-022353-q2k2krnm	699	5	epithelial	epithelial	JJ
cord-022353-q2k2krnm	699	6	cells	cell	NNS
cord-022353-q2k2krnm	699	7	from	from	IN
cord-022353-q2k2krnm	699	8	chemotherapy	chemotherapy	NN
cord-022353-q2k2krnm	699	9	and	and	CC
cord-022353-q2k2krnm	699	10	radiation	radiation	NN
cord-022353-q2k2krnm	699	11	injury	injury	NN
cord-022353-q2k2krnm	699	12	and	and	CC
cord-022353-q2k2krnm	699	13	ameliorates	ameliorate	VBZ
cord-022353-q2k2krnm	699	14	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	699	15	bowel	bowel	NN
cord-022353-q2k2krnm	699	16	disease	disease	NN
cord-022353-q2k2krnm	699	17	(	(	-LRB-
cord-022353-q2k2krnm	699	18	Schwertschlag	Schwertschlag	NNP
cord-022353-q2k2krnm	699	19	et	et	NNP
cord-022353-q2k2krnm	699	20	al	al	NNP
cord-022353-q2k2krnm	699	21	.	.	.
cord-022353-q2k2krnm	699	22	1999	1999	CD
cord-022353-q2k2krnm	699	23	)	)	-RRB-
cord-022353-q2k2krnm	699	24	.	.	.
cord-022353-q2k2krnm	700	1	IL-11	IL-11	NNP
cord-022353-q2k2krnm	700	2	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	700	3	adipogenesis	adipogenesis	NN
cord-022353-q2k2krnm	700	4	,	,	,
cord-022353-q2k2krnm	700	5	regulates	regulate	VBZ
cord-022353-q2k2krnm	700	6	neuronal	neuronal	JJ
cord-022353-q2k2krnm	700	7	differentiation	differentiation	NN
cord-022353-q2k2krnm	700	8	,	,	,
cord-022353-q2k2krnm	700	9	and	and	CC
cord-022353-q2k2krnm	700	10	regulates	regulate	VBZ
cord-022353-q2k2krnm	700	11	T	t	NN
cord-022353-q2k2krnm	700	12	-	-	HYPH
cord-022353-q2k2krnm	700	13	cell	cell	NN
cord-022353-q2k2krnm	700	14	function	function	NN
cord-022353-q2k2krnm	700	15	(	(	-LRB-
cord-022353-q2k2krnm	700	16	enhances	enhance	VBZ
cord-022353-q2k2krnm	700	17	TH2	TH2	NNP
cord-022353-q2k2krnm	700	18	and	and	CC
cord-022353-q2k2krnm	700	19	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	700	20	TH1	TH1	NNP
cord-022353-q2k2krnm	700	21	cytokine	cytokine	NN
cord-022353-q2k2krnm	700	22	production	production	NN
cord-022353-q2k2krnm	700	23	)	)	-RRB-
cord-022353-q2k2krnm	700	24	.	.	.
cord-022353-q2k2krnm	701	1	Overexpression	overexpression	NN
cord-022353-q2k2krnm	701	2	of	of	IN
cord-022353-q2k2krnm	701	3	IL-11	IL-11	NNP
cord-022353-q2k2krnm	701	4	in	in	IN
cord-022353-q2k2krnm	701	5	the	the	DT
cord-022353-q2k2krnm	701	6	lung	lung	NN
cord-022353-q2k2krnm	701	7	causes	cause	VBZ
cord-022353-q2k2krnm	701	8	airway	airway	NN
cord-022353-q2k2krnm	701	9	remodeling	remodeling	NN
cord-022353-q2k2krnm	701	10	,	,	,
cord-022353-q2k2krnm	701	11	fibrosis	fibrosis	NN
cord-022353-q2k2krnm	701	12	,	,	,
cord-022353-q2k2krnm	701	13	and	and	CC
cord-022353-q2k2krnm	701	14	mononuclear	mononuclear	JJ
cord-022353-q2k2krnm	701	15	nodules	nodule	NNS
cord-022353-q2k2krnm	701	16	analogous	analogous	JJ
cord-022353-q2k2krnm	701	17	to	to	IN
cord-022353-q2k2krnm	701	18	the	the	DT
cord-022353-q2k2krnm	701	19	clinical	clinical	JJ
cord-022353-q2k2krnm	701	20	picture	picture	NN
cord-022353-q2k2krnm	701	21	in	in	IN
cord-022353-q2k2krnm	701	22	chronic	chronic	JJ
cord-022353-q2k2krnm	701	23	asthma	asthma	NN
cord-022353-q2k2krnm	701	24	.	.	.
cord-022353-q2k2krnm	702	1	IL-11	IL-11	NNP
cord-022353-q2k2krnm	702	2	is	be	VBZ
cord-022353-q2k2krnm	702	3	also	also	RB
cord-022353-q2k2krnm	702	4	required	require	VBN
cord-022353-q2k2krnm	702	5	for	for	IN
cord-022353-q2k2krnm	702	6	the	the	DT
cord-022353-q2k2krnm	702	7	uterine	uterine	JJ
cord-022353-q2k2krnm	702	8	decidualization	decidualization	NN
cord-022353-q2k2krnm	702	9	response	response	NN
cord-022353-q2k2krnm	702	10	(	(	-LRB-
cord-022353-q2k2krnm	702	11	Robb	Robb	NNP
cord-022353-q2k2krnm	702	12	et	et	FW
cord-022353-q2k2krnm	702	13	al	al	NNP
cord-022353-q2k2krnm	702	14	.	.	.
cord-022353-q2k2krnm	702	15	2002	2002	CD
cord-022353-q2k2krnm	702	16	;	;	:
cord-022353-q2k2krnm	702	17	Zheng	Zheng	NNP
cord-022353-q2k2krnm	702	18	et	et	NNP
cord-022353-q2k2krnm	702	19	al	al	NNP
cord-022353-q2k2krnm	702	20	.	.	NNP
cord-022353-q2k2krnm	702	21	2001	2001	CD
cord-022353-q2k2krnm	702	22	)	)	-RRB-
cord-022353-q2k2krnm	702	23	.	.	.
cord-022353-q2k2krnm	703	1	xi	xi	NNP
cord-022353-q2k2krnm	703	2	.	.	.
cord-022353-q2k2krnm	703	3	IL-12	IL-12	NNP
cord-022353-q2k2krnm	703	4	,	,	,
cord-022353-q2k2krnm	703	5	also	also	RB
cord-022353-q2k2krnm	703	6	known	know	VBN
cord-022353-q2k2krnm	703	7	as	as	IN
cord-022353-q2k2krnm	703	8	natural	natural	JJ
cord-022353-q2k2krnm	703	9	killer	killer	NN
cord-022353-q2k2krnm	703	10	cell	cell	NN
cord-022353-q2k2krnm	703	11	stimulatory	stimulatory	JJ
cord-022353-q2k2krnm	703	12	factor	factor	NN
cord-022353-q2k2krnm	703	13	(	(	-LRB-
cord-022353-q2k2krnm	703	14	NKSF	NKSF	NNP
cord-022353-q2k2krnm	703	15	)	)	-RRB-
cord-022353-q2k2krnm	703	16	,	,	,
cord-022353-q2k2krnm	703	17	is	be	VBZ
cord-022353-q2k2krnm	703	18	a	a	DT
cord-022353-q2k2krnm	703	19	heterodimeric	heterodimeric	JJ
cord-022353-q2k2krnm	703	20	cytokine	cytokine	NN
cord-022353-q2k2krnm	703	21	composed	compose	VBN
cord-022353-q2k2krnm	703	22	of	of	IN
cord-022353-q2k2krnm	703	23	a	a	DT
cord-022353-q2k2krnm	703	24	40-kDa	40-kda	CD
cord-022353-q2k2krnm	703	25	(	(	-LRB-
cord-022353-q2k2krnm	703	26	p40	p40	NN
cord-022353-q2k2krnm	703	27	)	)	-RRB-
cord-022353-q2k2krnm	703	28	subunit	subunit	NN
cord-022353-q2k2krnm	703	29	and	and	CC
cord-022353-q2k2krnm	703	30	a	a	DT
cord-022353-q2k2krnm	703	31	35	35	CD
cord-022353-q2k2krnm	703	32	kDa	kDa	NNS
cord-022353-q2k2krnm	703	33	(	(	-LRB-
cord-022353-q2k2krnm	703	34	p35	p35	CD
cord-022353-q2k2krnm	703	35	)	)	-RRB-
cord-022353-q2k2krnm	703	36	subunit	subunit	NN
cord-022353-q2k2krnm	703	37	.	.	.
cord-022353-q2k2krnm	704	1	The	the	DT
cord-022353-q2k2krnm	704	2	p40	p40	NN
cord-022353-q2k2krnm	704	3	subunit	subunit	NN
cord-022353-q2k2krnm	704	4	is	be	VBZ
cord-022353-q2k2krnm	704	5	shared	share	VBN
cord-022353-q2k2krnm	704	6	by	by	IN
cord-022353-q2k2krnm	704	7	IL-23	IL-23	NNP
cord-022353-q2k2krnm	704	8	,	,	,
cord-022353-q2k2krnm	704	9	a	a	DT
cord-022353-q2k2krnm	704	10	cytokine	cytokine	NN
cord-022353-q2k2krnm	704	11	with	with	IN
cord-022353-q2k2krnm	704	12	similar	similar	JJ
cord-022353-q2k2krnm	704	13	activities	activity	NNS
cord-022353-q2k2krnm	704	14	.	.	.
cord-022353-q2k2krnm	705	1	Macrophage	macrophage	NN
cord-022353-q2k2krnm	705	2	,	,	,
cord-022353-q2k2krnm	705	3	monocytes	monocyte	NNS
cord-022353-q2k2krnm	705	4	,	,	,
cord-022353-q2k2krnm	705	5	and	and	CC
cord-022353-q2k2krnm	705	6	dendritic	dendritic	JJ
cord-022353-q2k2krnm	705	7	cells	cell	NNS
cord-022353-q2k2krnm	705	8	produce	produce	VBP
cord-022353-q2k2krnm	705	9	IL-12	IL-12	NNP
cord-022353-q2k2krnm	705	10	after	after	IN
cord-022353-q2k2krnm	705	11	activation	activation	NN
cord-022353-q2k2krnm	705	12	of	of	IN
cord-022353-q2k2krnm	705	13	Toll	Toll	NNP
cord-022353-q2k2krnm	705	14	-	-	HYPH
cord-022353-q2k2krnm	705	15	like	like	JJ
cord-022353-q2k2krnm	705	16	receptors	receptor	NNS
cord-022353-q2k2krnm	705	17	(	(	-LRB-
cord-022353-q2k2krnm	705	18	TLR	TLR	NNP
cord-022353-q2k2krnm	705	19	)	)	-RRB-
cord-022353-q2k2krnm	705	20	on	on	IN
cord-022353-q2k2krnm	705	21	these	these	DT
cord-022353-q2k2krnm	705	22	cells	cell	NNS
cord-022353-q2k2krnm	705	23	by	by	IN
cord-022353-q2k2krnm	705	24	bacterial	bacterial	JJ
cord-022353-q2k2krnm	705	25	ligands	ligand	NNS
cord-022353-q2k2krnm	705	26	.	.	.
cord-022353-q2k2krnm	706	1	IL-12	IL-12	NNP
cord-022353-q2k2krnm	706	2	induces	induce	VBZ
cord-022353-q2k2krnm	706	3	production	production	NN
cord-022353-q2k2krnm	706	4	of	of	IN
cord-022353-q2k2krnm	706	5	IFN-7by	IFN-7by	NNP
cord-022353-q2k2krnm	706	6	TH1	TH1	NNP
cord-022353-q2k2krnm	706	7	and	and	CC
cord-022353-q2k2krnm	706	8	NK	NK	NNP
cord-022353-q2k2krnm	706	9	cells	cell	NNS
cord-022353-q2k2krnm	706	10	and	and	CC
cord-022353-q2k2krnm	706	11	intact	intact	JJ
cord-022353-q2k2krnm	706	12	IL-12	il-12	PRP
cord-022353-q2k2krnm	706	13	skews	skew	VBZ
cord-022353-q2k2krnm	706	14	the	the	DT
cord-022353-q2k2krnm	706	15	balance	balance	NN
cord-022353-q2k2krnm	706	16	between	between	IN
cord-022353-q2k2krnm	706	17	TH	TH	NNP
cord-022353-q2k2krnm	706	18	subsets	subset	NNS
cord-022353-q2k2krnm	706	19	in	in	IN
cord-022353-q2k2krnm	706	20	favor	favor	NN
cord-022353-q2k2krnm	706	21	of	of	IN
cord-022353-q2k2krnm	706	22	TH1	th1	NN
cord-022353-q2k2krnm	706	23	cells	cell	NNS
cord-022353-q2k2krnm	706	24	.	.	.
cord-022353-q2k2krnm	707	1	IL-12	IL-12	NNP
cord-022353-q2k2krnm	707	2	binds	bind	VBZ
cord-022353-q2k2krnm	707	3	to	to	IN
cord-022353-q2k2krnm	707	4	the	the	DT
cord-022353-q2k2krnm	707	5	IL-12	IL-12	NNP
cord-022353-q2k2krnm	707	6	receptor	receptor	NN
cord-022353-q2k2krnm	707	7	that	that	WDT
cord-022353-q2k2krnm	707	8	is	be	VBZ
cord-022353-q2k2krnm	707	9	composed	compose	VBN
cord-022353-q2k2krnm	707	10	of	of	IN
cord-022353-q2k2krnm	707	11	two	two	CD
cord-022353-q2k2krnm	707	12	subunits	subunit	NNS
cord-022353-q2k2krnm	707	13	,	,	,
cord-022353-q2k2krnm	707	14	[	[	-LRB-
cord-022353-q2k2krnm	707	15	31	31	CD
cord-022353-q2k2krnm	707	16	and	and	CC
cord-022353-q2k2krnm	707	17	~2	~2	NNP
cord-022353-q2k2krnm	707	18	,	,	,
cord-022353-q2k2krnm	707	19	on	on	IN
cord-022353-q2k2krnm	707	20	the	the	DT
cord-022353-q2k2krnm	707	21	surface	surface	NN
cord-022353-q2k2krnm	707	22	of	of	IN
cord-022353-q2k2krnm	707	23	NK	NK	NNP
cord-022353-q2k2krnm	707	24	and	and	CC
cord-022353-q2k2krnm	707	25	TH1	th1	NN
cord-022353-q2k2krnm	707	26	cells	cell	NNS
cord-022353-q2k2krnm	707	27	.	.	.
cord-022353-q2k2krnm	708	1	IL-12p40	IL-12p40	NNP
cord-022353-q2k2krnm	708	2	interacts	interact	VBZ
cord-022353-q2k2krnm	708	3	with	with	IN
cord-022353-q2k2krnm	708	4	IL-12R[31	IL-12R[31	NNP
cord-022353-q2k2krnm	708	5	,	,	,
cord-022353-q2k2krnm	708	6	and	and	CC
cord-022353-q2k2krnm	708	7	IL-12p35	IL-12p35	NNP
cord-022353-q2k2krnm	708	8	binds	bind	VBZ
cord-022353-q2k2krnm	708	9	IL-12R[32	IL-12R[32	NNP
cord-022353-q2k2krnm	708	10	.	.	.
cord-022353-q2k2krnm	709	1	Negative	negative	JJ
cord-022353-q2k2krnm	709	2	feedback	feedback	NN
cord-022353-q2k2krnm	709	3	regulation	regulation	NN
cord-022353-q2k2krnm	709	4	of	of	IN
cord-022353-q2k2krnm	709	5	IL-12	IL-12	NNP
cord-022353-q2k2krnm	709	6	production	production	NN
cord-022353-q2k2krnm	709	7	involves	involve	VBZ
cord-022353-q2k2krnm	709	8	down	down	RP
cord-022353-q2k2krnm	709	9	regulation	regulation	NN
cord-022353-q2k2krnm	709	10	of	of	IN
cord-022353-q2k2krnm	709	11	TLR	TLR	NNP
cord-022353-q2k2krnm	709	12	signaling	signal	VBG
cord-022353-q2k2krnm	709	13	by	by	IN
cord-022353-q2k2krnm	709	14	phosphoinositide	phosphoinositide	NNP
cord-022353-q2k2krnm	709	15	3-kinases	3-kinases	CD
cord-022353-q2k2krnm	709	16	(	(	-LRB-
cord-022353-q2k2krnm	709	17	PIKs	PIKs	NNP
cord-022353-q2k2krnm	709	18	)	)	-RRB-
cord-022353-q2k2krnm	709	19	.	.	.
cord-022353-q2k2krnm	710	1	Thus	thus	RB
cord-022353-q2k2krnm	710	2	IL-12	IL-12	NNP
cord-022353-q2k2krnm	710	3	is	be	VBZ
cord-022353-q2k2krnm	710	4	centrally	centrally	RB
cord-022353-q2k2krnm	710	5	involved	involve	VBN
cord-022353-q2k2krnm	710	6	at	at	IN
cord-022353-q2k2krnm	710	7	the	the	DT
cord-022353-q2k2krnm	710	8	interface	interface	NN
cord-022353-q2k2krnm	710	9	of	of	IN
cord-022353-q2k2krnm	710	10	innate	innate	JJ
cord-022353-q2k2krnm	710	11	and	and	CC
cord-022353-q2k2krnm	710	12	adaptive	adaptive	JJ
cord-022353-q2k2krnm	710	13	immunity	immunity	NN
cord-022353-q2k2krnm	710	14	(	(	-LRB-
cord-022353-q2k2krnm	710	15	Fukao	Fukao	NNP
cord-022353-q2k2krnm	710	16	and	and	CC
cord-022353-q2k2krnm	710	17	Koyasu	Koyasu	NNP
cord-022353-q2k2krnm	710	18	2003	2003	CD
cord-022353-q2k2krnm	710	19	"	"	``
cord-022353-q2k2krnm	710	20	Ottenhoff	Ottenhoff	NNP
cord-022353-q2k2krnm	710	21	et	et	NNP
cord-022353-q2k2krnm	710	22	al	al	NNP
cord-022353-q2k2krnm	710	23	.	.	.
cord-022353-q2k2krnm	710	24	2002	2002	CD
cord-022353-q2k2krnm	710	25	)	)	-RRB-
cord-022353-q2k2krnm	710	26	.	.	.
cord-022353-q2k2krnm	711	1	xit	xit	NNP
cord-022353-q2k2krnm	711	2	,	,	,
cord-022353-q2k2krnm	711	3	IL-13	IL-13	NNP
cord-022353-q2k2krnm	711	4	,	,	,
cord-022353-q2k2krnm	711	5	along	along	IN
cord-022353-q2k2krnm	711	6	with	with	IN
cord-022353-q2k2krnm	711	7	IL-4	IL-4	NNP
cord-022353-q2k2krnm	711	8	and	and	CC
cord-022353-q2k2krnm	711	9	IL-5	IL-5	NNP
cord-022353-q2k2krnm	711	10	,	,	,
cord-022353-q2k2krnm	711	11	is	be	VBZ
cord-022353-q2k2krnm	711	12	a	a	DT
cord-022353-q2k2krnm	711	13	member	member	NN
cord-022353-q2k2krnm	711	14	of	of	IN
cord-022353-q2k2krnm	711	15	the	the	DT
cord-022353-q2k2krnm	711	16	type-2	type-2	NNP
cord-022353-q2k2krnm	711	17	cytokine	cytokine	NN
cord-022353-q2k2krnm	711	18	family	family	NN
cord-022353-q2k2krnm	711	19	and	and	CC
cord-022353-q2k2krnm	711	20	as	as	IN
cord-022353-q2k2krnm	711	21	such	such	JJ
cord-022353-q2k2krnm	711	22	is	be	VBZ
cord-022353-q2k2krnm	711	23	involved	involve	VBN
cord-022353-q2k2krnm	711	24	in	in	IN
cord-022353-q2k2krnm	711	25	inflammation	inflammation	NN
cord-022353-q2k2krnm	711	26	,	,	,
cord-022353-q2k2krnm	711	27	mucus	mucus	NN
cord-022353-q2k2krnm	711	28	production	production	NN
cord-022353-q2k2krnm	711	29	,	,	,
cord-022353-q2k2krnm	711	30	tissue	tissue	NN
cord-022353-q2k2krnm	711	31	remodeling	remodeling	NN
cord-022353-q2k2krnm	711	32	,	,	,
cord-022353-q2k2krnm	711	33	and	and	CC
cord-022353-q2k2krnm	711	34	fibrosis	fibrosis	NN
cord-022353-q2k2krnm	711	35	.	.	.
cord-022353-q2k2krnm	712	1	This	this	DT
cord-022353-q2k2krnm	712	2	single	single	JJ
cord-022353-q2k2krnm	712	3	-	-	HYPH
cord-022353-q2k2krnm	712	4	chain	chain	NN
cord-022353-q2k2krnm	712	5	protein	protein	NN
cord-022353-q2k2krnm	712	6	shares	share	NNS
cord-022353-q2k2krnm	712	7	58	58	CD
cord-022353-q2k2krnm	712	8	%	%	NN
cord-022353-q2k2krnm	712	9	amino	amino	NN
cord-022353-q2k2krnm	712	10	acid	acid	NN
cord-022353-q2k2krnm	712	11	sequence	sequence	NN
cord-022353-q2k2krnm	712	12	homology	homology	NN
cord-022353-q2k2krnm	712	13	with	with	IN
cord-022353-q2k2krnm	712	14	human	human	JJ
cord-022353-q2k2krnm	712	15	IL-13	IL-13	NNP
cord-022353-q2k2krnm	712	16	.	.	.
cord-022353-q2k2krnm	713	1	IL-13	IL-13	NNP
cord-022353-q2k2krnm	713	2	is	be	VBZ
cord-022353-q2k2krnm	713	3	produced	produce	VBN
cord-022353-q2k2krnm	713	4	by	by	IN
cord-022353-q2k2krnm	713	5	activated	activate	VBN
cord-022353-q2k2krnm	713	6	T	t	NN
cord-022353-q2k2krnm	713	7	cells	cell	NNS
cord-022353-q2k2krnm	713	8	,	,	,
cord-022353-q2k2krnm	713	9	mast	mast	NN
cord-022353-q2k2krnm	713	10	cells	cell	NNS
cord-022353-q2k2krnm	713	11	,	,	,
cord-022353-q2k2krnm	713	12	and	and	CC
cord-022353-q2k2krnm	713	13	NK	NK	NNP
cord-022353-q2k2krnm	713	14	cells	cell	NNS
cord-022353-q2k2krnm	713	15	and	and	CC
cord-022353-q2k2krnm	713	16	promotes	promote	VBZ
cord-022353-q2k2krnm	713	17	TH2	TH2	NNP
cord-022353-q2k2krnm	713	18	responses	response	NNS
cord-022353-q2k2krnm	713	19	including	include	VBG
cord-022353-q2k2krnm	713	20	synthesis	synthesis	NN
cord-022353-q2k2krnm	713	21	of	of	IN
cord-022353-q2k2krnm	713	22	IgE.	ige.	NN
cord-022353-q2k2krnm	714	1	Signaling	signaling	NN
cord-022353-q2k2krnm	714	2	is	be	VBZ
cord-022353-q2k2krnm	714	3	mediated	mediate	VBN
cord-022353-q2k2krnm	714	4	by	by	IN
cord-022353-q2k2krnm	714	5	the	the	DT
cord-022353-q2k2krnm	714	6	type-2	type-2	NN
cord-022353-q2k2krnm	714	7	IL-4	IL-4	NNP
cord-022353-q2k2krnm	714	8	receptor	receptor	NN
cord-022353-q2k2krnm	714	9	which	which	WDT
cord-022353-q2k2krnm	714	10	consists	consist	VBZ
cord-022353-q2k2krnm	714	11	of	of	IN
cord-022353-q2k2krnm	714	12	IL-4R~	IL-4R~	NNP
cord-022353-q2k2krnm	714	13	and	and	CC
cord-022353-q2k2krnm	714	14	IL-13Rc	IL-13Rc	NNP
cord-022353-q2k2krnm	715	1	~I	~I	NFP
cord-022353-q2k2krnm	715	2	chains	chain	NNS
cord-022353-q2k2krnm	715	3	.	.	.
cord-022353-q2k2krnm	716	1	Another	another	DT
cord-022353-q2k2krnm	716	2	IL-13	IL-13	NNP
cord-022353-q2k2krnm	716	3	binding	bind	VBG
cord-022353-q2k2krnm	716	4	protein	protein	NN
cord-022353-q2k2krnm	716	5	,	,	,
cord-022353-q2k2krnm	716	6	IL-13R~2	IL-13R~2	NNS
cord-022353-q2k2krnm	716	7	,	,	,
cord-022353-q2k2krnm	716	8	strongly	strongly	RB
cord-022353-q2k2krnm	716	9	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	716	10	the	the	DT
cord-022353-q2k2krnm	716	11	activity	activity	NN
cord-022353-q2k2krnm	716	12	of	of	IN
cord-022353-q2k2krnm	716	13	IL-13	IL-13	NNP
cord-022353-q2k2krnm	716	14	(	(	-LRB-
cord-022353-q2k2krnm	716	15	Goldsby	Goldsby	NNP
cord-022353-q2k2krnm	716	16	et	et	FW
cord-022353-q2k2krnm	716	17	al	al	NNP
cord-022353-q2k2krnm	716	18	.	.	.
cord-022353-q2k2krnm	717	1	2003	2003	CD
cord-022353-q2k2krnm	717	2	;	;	:
cord-022353-q2k2krnm	717	3	Mentink	Mentink	NNP
cord-022353-q2k2krnm	717	4	-	-	HYPH
cord-022353-q2k2krnm	717	5	Kane	Kane	NNP
cord-022353-q2k2krnm	717	6	and	and	CC
cord-022353-q2k2krnm	717	7	Wynn	Wynn	NNP
cord-022353-q2k2krnm	717	8	,	,	,
cord-022353-q2k2krnm	717	9	2004	2004	CD
cord-022353-q2k2krnm	717	10	)	)	-RRB-
cord-022353-q2k2krnm	717	11	.	.	.
cord-022353-q2k2krnm	718	1	xiii	xiii	NNP
cord-022353-q2k2krnm	718	2	.	.	.
cord-022353-q2k2krnm	719	1	IL-17	IL-17	NNP
cord-022353-q2k2krnm	719	2	,	,	,
cord-022353-q2k2krnm	719	3	also	also	RB
cord-022353-q2k2krnm	719	4	known	know	VBN
cord-022353-q2k2krnm	719	5	as	as	IN
cord-022353-q2k2krnm	719	6	cytotoxic	cytotoxic	JJ
cord-022353-q2k2krnm	719	7	T	T	NNP
cord-022353-q2k2krnm	719	8	lymphocyte	lymphocyte	NN
cord-022353-q2k2krnm	719	9	-	-	HYPH
cord-022353-q2k2krnm	719	10	associated	associate	VBN
cord-022353-q2k2krnm	719	11	antigen-8	antigen-8	NNP
cord-022353-q2k2krnm	719	12	(	(	-LRB-
cord-022353-q2k2krnm	719	13	CTLA-8	CTLA-8	NNP
cord-022353-q2k2krnm	719	14	)	)	-RRB-
cord-022353-q2k2krnm	719	15	,	,	,
cord-022353-q2k2krnm	719	16	is	be	VBZ
cord-022353-q2k2krnm	719	17	produced	produce	VBN
cord-022353-q2k2krnm	719	18	by	by	IN
cord-022353-q2k2krnm	719	19	T	T	NNP
cord-022353-q2k2krnm	719	20	cells	cell	NNS
cord-022353-q2k2krnm	719	21	and	and	CC
cord-022353-q2k2krnm	719	22	is	be	VBZ
cord-022353-q2k2krnm	719	23	pleiotropic	pleiotropic	JJ
cord-022353-q2k2krnm	719	24	in	in	IN
cord-022353-q2k2krnm	719	25	activity	activity	NN
cord-022353-q2k2krnm	719	26	.	.	.
cord-022353-q2k2krnm	720	1	IL-17	IL-17	NNP
cord-022353-q2k2krnm	720	2	is	be	VBZ
cord-022353-q2k2krnm	720	3	a	a	DT
cord-022353-q2k2krnm	720	4	158	158	CD
cord-022353-q2k2krnm	720	5	amino	amino	NN
cord-022353-q2k2krnm	720	6	acid	acid	NN
cord-022353-q2k2krnm	720	7	residue	residue	NN
cord-022353-q2k2krnm	720	8	polypeptide	polypeptide	NN
cord-022353-q2k2krnm	720	9	with	with	IN
cord-022353-q2k2krnm	720	10	a	a	DT
cord-022353-q2k2krnm	720	11	21	21	CD
cord-022353-q2k2krnm	720	12	amino	amino	NN
cord-022353-q2k2krnm	720	13	acid	acid	NN
cord-022353-q2k2krnm	720	14	signal	signal	NN
cord-022353-q2k2krnm	720	15	sequence	sequence	NN
cord-022353-q2k2krnm	720	16	and	and	CC
cord-022353-q2k2krnm	720	17	a	a	DT
cord-022353-q2k2krnm	720	18	mature	mature	JJ
cord-022353-q2k2krnm	720	19	polypeptide	polypeptide	NN
cord-022353-q2k2krnm	720	20	of	of	IN
cord-022353-q2k2krnm	720	21	137	137	CD
cord-022353-q2k2krnm	720	22	amino	amino	JJ
cord-022353-q2k2krnm	720	23	acids	acid	NNS
cord-022353-q2k2krnm	720	24	.	.	.
cord-022353-q2k2krnm	721	1	It	-PRON-	PRP
cord-022353-q2k2krnm	721	2	is	be	VBZ
cord-022353-q2k2krnm	721	3	a	a	DT
cord-022353-q2k2krnm	721	4	disulfide	disulfide	RB
cord-022353-q2k2krnm	721	5	-	-	HYPH
cord-022353-q2k2krnm	721	6	linked	link	VBN
cord-022353-q2k2krnm	721	7	homodimer	homodimer	RB
cord-022353-q2k2krnm	721	8	.	.	.
cord-022353-q2k2krnm	722	1	Based	base	VBN
cord-022353-q2k2krnm	722	2	on	on	IN
cord-022353-q2k2krnm	722	3	the	the	DT
cord-022353-q2k2krnm	722	4	presence	presence	NN
cord-022353-q2k2krnm	722	5	of	of	IN
cord-022353-q2k2krnm	722	6	spatially	spatially	RB
cord-022353-q2k2krnm	722	7	conserved	conserve	VBN
cord-022353-q2k2krnm	722	8	cysteine	cysteine	NN
cord-022353-q2k2krnm	722	9	residues	residue	NNS
cord-022353-q2k2krnm	722	10	in	in	IN
cord-022353-q2k2krnm	722	11	the	the	DT
cord-022353-q2k2krnm	722	12	IL-17	IL-17	NNP
cord-022353-q2k2krnm	722	13	family	family	NN
cord-022353-q2k2krnm	722	14	of	of	IN
cord-022353-q2k2krnm	722	15	proteins	protein	NNS
cord-022353-q2k2krnm	722	16	,	,	,
cord-022353-q2k2krnm	722	17	there	there	EX
cord-022353-q2k2krnm	722	18	are	be	VBP
cord-022353-q2k2krnm	722	19	six	six	CD
cord-022353-q2k2krnm	722	20	family	family	NN
cord-022353-q2k2krnm	722	21	members	member	NNS
cord-022353-q2k2krnm	722	22	in	in	IN
cord-022353-q2k2krnm	722	23	humans	human	NNS
cord-022353-q2k2krnm	722	24	and	and	CC
cord-022353-q2k2krnm	722	25	mice	mouse	NNS
cord-022353-q2k2krnm	722	26	,	,	,
cord-022353-q2k2krnm	722	27	IL-17	IL-17	NNP
cord-022353-q2k2krnm	722	28	,	,	,
cord-022353-q2k2krnm	722	29	IL-17B	IL-17B	NNP
cord-022353-q2k2krnm	722	30	,	,	,
cord-022353-q2k2krnm	722	31	IL-17C	il-17c	NN
cord-022353-q2k2krnm	722	32	,	,	,
cord-022353-q2k2krnm	722	33	IL-17D	il-17d	NN
cord-022353-q2k2krnm	722	34	,	,	,
cord-022353-q2k2krnm	722	35	IL-17E	IL-17E	NNP
cord-022353-q2k2krnm	722	36	,	,	,
cord-022353-q2k2krnm	722	37	and	and	CC
cord-022353-q2k2krnm	722	38	IL-17F	IL-17F	NNP
cord-022353-q2k2krnm	722	39	(	(	-LRB-
cord-022353-q2k2krnm	722	40	Aggarwal	Aggarwal	NNP
cord-022353-q2k2krnm	722	41	and	and	CC
cord-022353-q2k2krnm	722	42	Gurney	Gurney	NNP
cord-022353-q2k2krnm	722	43	2002	2002	CD
cord-022353-q2k2krnm	722	44	)	)	-RRB-
cord-022353-q2k2krnm	722	45	.	.	.
cord-022353-q2k2krnm	723	1	Like	like	IN
cord-022353-q2k2krnm	723	2	IL-17	IL-17	NNP
cord-022353-q2k2krnm	723	3	itself	-PRON-	PRP
cord-022353-q2k2krnm	723	4	,	,	,
cord-022353-q2k2krnm	723	5	several	several	JJ
cord-022353-q2k2krnm	723	6	of	of	IN
cord-022353-q2k2krnm	723	7	the	the	DT
cord-022353-q2k2krnm	723	8	family	family	NN
cord-022353-q2k2krnm	723	9	members	member	NNS
cord-022353-q2k2krnm	723	10	appear	appear	VBP
cord-022353-q2k2krnm	723	11	to	to	TO
cord-022353-q2k2krnm	723	12	modulate	modulate	VB
cord-022353-q2k2krnm	723	13	immune	immune	JJ
cord-022353-q2k2krnm	723	14	function	function	NN
cord-022353-q2k2krnm	723	15	.	.	.
cord-022353-q2k2krnm	724	1	Produced	produce	VBN
cord-022353-q2k2krnm	724	2	by	by	IN
cord-022353-q2k2krnm	724	3	mouse	mouse	NN
cord-022353-q2k2krnm	724	4	CD4	CD4	NNP
cord-022353-q2k2krnm	724	5	§	§	:
cord-022353-q2k2krnm	724	6	T	T	NNP
cord-022353-q2k2krnm	724	7	cells	cell	NNS
cord-022353-q2k2krnm	724	8	,	,	,
cord-022353-q2k2krnm	724	9	IL-17	IL-17	NNP
cord-022353-q2k2krnm	724	10	induces	induce	VBZ
cord-022353-q2k2krnm	724	11	IL-6	IL-6	NNP
cord-022353-q2k2krnm	724	12	,	,	,
cord-022353-q2k2krnm	724	13	MCP-1	MCP-1	NNP
cord-022353-q2k2krnm	724	14	,	,	,
cord-022353-q2k2krnm	724	15	prostaglandin	prostaglandin	NN
cord-022353-q2k2krnm	724	16	-	-	HYPH
cord-022353-q2k2krnm	724	17	E2	e2	NN
cord-022353-q2k2krnm	724	18	(	(	-LRB-
cord-022353-q2k2krnm	724	19	PGE2	PGE2	NNP
cord-022353-q2k2krnm	724	20	)	)	-RRB-
cord-022353-q2k2krnm	724	21	and	and	CC
cord-022353-q2k2krnm	724	22	granulocyte	granulocyte	NN
cord-022353-q2k2krnm	724	23	colony	colony	NN
cord-022353-q2k2krnm	724	24	-	-	HYPH
cord-022353-q2k2krnm	724	25	stimulating	stimulate	VBG
cord-022353-q2k2krnm	724	26	factor	factor	NN
cord-022353-q2k2krnm	724	27	(	(	-LRB-
cord-022353-q2k2krnm	724	28	G	G	NNP
cord-022353-q2k2krnm	724	29	-	-	HYPH
cord-022353-q2k2krnm	724	30	CSF	CSF	NNP
cord-022353-q2k2krnm	724	31	)	)	-RRB-
cord-022353-q2k2krnm	724	32	by	by	IN
cord-022353-q2k2krnm	724	33	fibroblasts	fibroblast	NNS
cord-022353-q2k2krnm	724	34	,	,	,
cord-022353-q2k2krnm	724	35	keratinocytes	keratinocyte	NNS
cord-022353-q2k2krnm	724	36	,	,	,
cord-022353-q2k2krnm	724	37	epithelial	epithelial	JJ
cord-022353-q2k2krnm	724	38	cells	cell	NNS
cord-022353-q2k2krnm	724	39	,	,	,
cord-022353-q2k2krnm	724	40	and	and	CC
cord-022353-q2k2krnm	724	41	endothelial	endothelial	JJ
cord-022353-q2k2krnm	724	42	cells	cell	NNS
cord-022353-q2k2krnm	724	43	.	.	.
cord-022353-q2k2krnm	725	1	It	-PRON-	PRP
cord-022353-q2k2krnm	725	2	induces	induce	VBZ
cord-022353-q2k2krnm	725	3	ICAM-1	icam-1	NN
cord-022353-q2k2krnm	725	4	surface	surface	NN
cord-022353-q2k2krnm	725	5	expression	expression	NN
cord-022353-q2k2krnm	725	6	,	,	,
cord-022353-q2k2krnm	725	7	proliferation	proliferation	NN
cord-022353-q2k2krnm	725	8	of	of	IN
cord-022353-q2k2krnm	725	9	T	t	NN
cord-022353-q2k2krnm	725	10	cells	cell	NNS
cord-022353-q2k2krnm	725	11	,	,	,
cord-022353-q2k2krnm	725	12	and	and	CC
cord-022353-q2k2krnm	725	13	the	the	DT
cord-022353-q2k2krnm	725	14	differentiation	differentiation	NN
cord-022353-q2k2krnm	725	15	of	of	IN
cord-022353-q2k2krnm	725	16	CD34	CD34	NNP
cord-022353-q2k2krnm	725	17	+	+	CC
cord-022353-q2k2krnm	725	18	marrow	marrow	NN
cord-022353-q2k2krnm	725	19	progenitors	progenitor	NNS
cord-022353-q2k2krnm	725	20	into	into	IN
cord-022353-q2k2krnm	725	21	neutrophils	neutrophil	NNS
cord-022353-q2k2krnm	725	22	(	(	-LRB-
cord-022353-q2k2krnm	725	23	Fossiez	Fossiez	NNP
cord-022353-q2k2krnm	725	24	et	et	NNP
cord-022353-q2k2krnm	725	25	al	al	NNP
cord-022353-q2k2krnm	725	26	.	.	NNP
cord-022353-q2k2krnm	725	27	1998	1998	CD
cord-022353-q2k2krnm	725	28	)	)	-RRB-
cord-022353-q2k2krnm	725	29	.	.	.
cord-022353-q2k2krnm	726	1	The	the	DT
cord-022353-q2k2krnm	726	2	ubiquitously	ubiquitously	RB
cord-022353-q2k2krnm	726	3	distributed	distribute	VBN
cord-022353-q2k2krnm	726	4	receptor	receptor	NN
cord-022353-q2k2krnm	726	5	is	be	VBZ
cord-022353-q2k2krnm	726	6	a	a	DT
cord-022353-q2k2krnm	726	7	type	type	NN
cord-022353-q2k2krnm	726	8	1	1	CD
cord-022353-q2k2krnm	726	9	transmembrane	transmembrane	NN
cord-022353-q2k2krnm	726	10	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	726	11	of	of	IN
cord-022353-q2k2krnm	726	12	830	830	CD
cord-022353-q2k2krnm	726	13	amino	amino	NN
cord-022353-q2k2krnm	726	14	acids	acid	NNS
cord-022353-q2k2krnm	726	15	in	in	IN
cord-022353-q2k2krnm	726	16	length	length	NN
cord-022353-q2k2krnm	726	17	.	.	.
cord-022353-q2k2krnm	727	1	xiv	xiv	NNP
cord-022353-q2k2krnm	727	2	.	.	.
cord-022353-q2k2krnm	727	3	IL-18	IL-18	NNP
cord-022353-q2k2krnm	727	4	is	be	VBZ
cord-022353-q2k2krnm	727	5	a	a	DT
cord-022353-q2k2krnm	727	6	24-kDa	24-kda	CD
cord-022353-q2k2krnm	727	7	,	,	,
cord-022353-q2k2krnm	727	8	nonglycosylated	nonglycosylated	JJ
cord-022353-q2k2krnm	727	9	polypeptide	polypeptide	NN
cord-022353-q2k2krnm	727	10	that	that	WDT
cord-022353-q2k2krnm	727	11	lacks	lack	VBZ
cord-022353-q2k2krnm	727	12	a	a	DT
cord-022353-q2k2krnm	727	13	classical	classical	JJ
cord-022353-q2k2krnm	727	14	signaling	signaling	NN
cord-022353-q2k2krnm	727	15	sequence	sequence	NN
cord-022353-q2k2krnm	727	16	.	.	.
cord-022353-q2k2krnm	728	1	Its	-PRON-	PRP$
cord-022353-q2k2krnm	728	2	structure	structure	NN
cord-022353-q2k2krnm	728	3	resembles	resemble	VBZ
cord-022353-q2k2krnm	728	4	IL-1	IL-1	NNP
cord-022353-q2k2krnm	728	5	and	and	CC
cord-022353-q2k2krnm	728	6	the	the	DT
cord-022353-q2k2krnm	728	7	propeptide	propeptide	NN
cord-022353-q2k2krnm	728	8	undergoes	undergo	VBZ
cord-022353-q2k2krnm	728	9	proteolytic	proteolytic	JJ
cord-022353-q2k2krnm	728	10	cleavage	cleavage	NN
cord-022353-q2k2krnm	728	11	by	by	IN
cord-022353-q2k2krnm	728	12	interleukin-1	interleukin-1	NN
cord-022353-q2k2krnm	728	13	[	[	-LRB-
cord-022353-q2k2krnm	728	14	3-converting	3-converting	CD
cord-022353-q2k2krnm	728	15	enzyme	enzyme	NN
cord-022353-q2k2krnm	728	16	(	(	-LRB-
cord-022353-q2k2krnm	728	17	ICE	ice	NN
cord-022353-q2k2krnm	728	18	)	)	-RRB-
cord-022353-q2k2krnm	728	19	or	or	CC
cord-022353-q2k2krnm	728	20	another	another	DT
cord-022353-q2k2krnm	728	21	caspase	caspase	NN
cord-022353-q2k2krnm	728	22	to	to	TO
cord-022353-q2k2krnm	728	23	produce	produce	VB
cord-022353-q2k2krnm	728	24	an	an	DT
cord-022353-q2k2krnm	728	25	18-kDa	18-kda	CD
cord-022353-q2k2krnm	728	26	bioactive	bioactive	JJ
cord-022353-q2k2krnm	728	27	molecule	molecule	NN
cord-022353-q2k2krnm	728	28	.	.	.
cord-022353-q2k2krnm	729	1	There	there	EX
cord-022353-q2k2krnm	729	2	is	be	VBZ
cord-022353-q2k2krnm	729	3	64	64	CD
cord-022353-q2k2krnm	729	4	%	%	NN
cord-022353-q2k2krnm	729	5	sequence	sequence	NN
cord-022353-q2k2krnm	729	6	homology	homology	NN
cord-022353-q2k2krnm	729	7	between	between	IN
cord-022353-q2k2krnm	729	8	mouse	mouse	NN
cord-022353-q2k2krnm	729	9	and	and	CC
cord-022353-q2k2krnm	729	10	human	human	NN
cord-022353-q2k2krnm	729	11	IL-18	IL-18	NNP
cord-022353-q2k2krnm	729	12	.	.	.
cord-022353-q2k2krnm	729	13	IL-18	IL-18	NNP
cord-022353-q2k2krnm	729	14	induces	induce	VBZ
cord-022353-q2k2krnm	729	15	the	the	DT
cord-022353-q2k2krnm	729	16	production	production	NN
cord-022353-q2k2krnm	729	17	of	of	IN
cord-022353-q2k2krnm	729	18	IFN-7	IFN-7	NNP
cord-022353-q2k2krnm	729	19	by	by	IN
cord-022353-q2k2krnm	729	20	T	T	NNP
cord-022353-q2k2krnm	729	21	cells	cell	NNS
cord-022353-q2k2krnm	729	22	and	and	CC
cord-022353-q2k2krnm	729	23	NK	NK	NNP
cord-022353-q2k2krnm	729	24	cells	cell	NNS
cord-022353-q2k2krnm	729	25	and	and	CC
cord-022353-q2k2krnm	729	26	the	the	DT
cord-022353-q2k2krnm	729	27	expression	expression	NN
cord-022353-q2k2krnm	729	28	of	of	IN
cord-022353-q2k2krnm	729	29	Fas	Fas	NNP
cord-022353-q2k2krnm	729	30	ligand	ligand	NN
cord-022353-q2k2krnm	729	31	(	(	-LRB-
cord-022353-q2k2krnm	729	32	FasL	FasL	NNP
cord-022353-q2k2krnm	729	33	)	)	-RRB-
cord-022353-q2k2krnm	729	34	on	on	IN
cord-022353-q2k2krnm	729	35	a	a	DT
cord-022353-q2k2krnm	729	36	variety	variety	NN
cord-022353-q2k2krnm	729	37	of	of	IN
cord-022353-q2k2krnm	729	38	all	all	DT
cord-022353-q2k2krnm	729	39	types	type	NNS
cord-022353-q2k2krnm	729	40	.	.	.
cord-022353-q2k2krnm	730	1	IL-18	IL-18	NNP
cord-022353-q2k2krnm	730	2	activates	activate	VBZ
cord-022353-q2k2krnm	730	3	NF-~:[3	NF-~:[3	NNP
cord-022353-q2k2krnm	730	4	and	and	CC
cord-022353-q2k2krnm	730	5	the	the	DT
cord-022353-q2k2krnm	730	6	induction	induction	NN
cord-022353-q2k2krnm	730	7	of	of	IN
cord-022353-q2k2krnm	730	8	various	various	JJ
cord-022353-q2k2krnm	730	9	chemokines	chemokine	NNS
cord-022353-q2k2krnm	730	10	.	.	.
cord-022353-q2k2krnm	731	1	IL-18	IL-18	NNP
cord-022353-q2k2krnm	731	2	plays	play	VBZ
cord-022353-q2k2krnm	731	3	an	an	DT
cord-022353-q2k2krnm	731	4	important	important	JJ
cord-022353-q2k2krnm	731	5	role	role	NN
cord-022353-q2k2krnm	731	6	in	in	IN
cord-022353-q2k2krnm	731	7	the	the	DT
cord-022353-q2k2krnm	731	8	early	early	JJ
cord-022353-q2k2krnm	731	9	antibacterial	antibacterial	JJ
cord-022353-q2k2krnm	731	10	host	host	NN
cord-022353-q2k2krnm	731	11	response	response	NN
cord-022353-q2k2krnm	731	12	(	(	-LRB-
cord-022353-q2k2krnm	731	13	Weijer	Weijer	NNP
cord-022353-q2k2krnm	731	14	et	et	FW
cord-022353-q2k2krnm	731	15	al	al	NNP
cord-022353-q2k2krnm	731	16	.	.	NNP
cord-022353-q2k2krnm	731	17	2003	2003	CD
cord-022353-q2k2krnm	731	18	)	)	-RRB-
cord-022353-q2k2krnm	731	19	.	.	.
cord-022353-q2k2krnm	732	1	xv	xv	NNP
cord-022353-q2k2krnm	732	2	.	.	.
cord-022353-q2k2krnm	733	1	AND	and	CC
cord-022353-q2k2krnm	733	2	IL-20	IL-20	NNP
cord-022353-q2k2krnm	733	3	induces	induce	VBZ
cord-022353-q2k2krnm	733	4	keratinocyte	keratinocyte	JJ
cord-022353-q2k2krnm	733	5	differentiation	differentiation	NN
cord-022353-q2k2krnm	733	6	and	and	CC
cord-022353-q2k2krnm	733	7	proliferation	proliferation	NN
cord-022353-q2k2krnm	733	8	.	.	.
cord-022353-q2k2krnm	734	1	IL-21	IL-21	NNP
cord-022353-q2k2krnm	734	2	is	be	VBZ
cord-022353-q2k2krnm	734	3	a	a	DT
cord-022353-q2k2krnm	734	4	four	four	CD
cord-022353-q2k2krnm	734	5	-	-	HYPH
cord-022353-q2k2krnm	734	6	helix	helix	NN
cord-022353-q2k2krnm	734	7	-	-	HYPH
cord-022353-q2k2krnm	734	8	bundle	bundle	NN
cord-022353-q2k2krnm	734	9	cytokine	cytokine	NN
cord-022353-q2k2krnm	734	10	similar	similar	JJ
cord-022353-q2k2krnm	734	11	in	in	IN
cord-022353-q2k2krnm	734	12	structure	structure	NN
cord-022353-q2k2krnm	734	13	to	to	IN
cord-022353-q2k2krnm	734	14	IL-15	IL-15	NNP
cord-022353-q2k2krnm	734	15	and	and	CC
cord-022353-q2k2krnm	734	16	sharing	share	VBG
cord-022353-q2k2krnm	734	17	sequence	sequence	NN
cord-022353-q2k2krnm	734	18	homology	homology	NN
cord-022353-q2k2krnm	734	19	with	with	IN
cord-022353-q2k2krnm	734	20	IL-2	IL-2	NNP
cord-022353-q2k2krnm	734	21	and	and	CC
cord-022353-q2k2krnm	734	22	IL-4	IL-4	NNP
cord-022353-q2k2krnm	734	23	.	.	.
cord-022353-q2k2krnm	735	1	Murine	Murine	NNP
cord-022353-q2k2krnm	735	2	IL-21	IL-21	NNP
cord-022353-q2k2krnm	735	3	is	be	VBZ
cord-022353-q2k2krnm	735	4	57	57	CD
cord-022353-q2k2krnm	735	5	%	%	NN
cord-022353-q2k2krnm	735	6	homologous	homologous	JJ
cord-022353-q2k2krnm	735	7	to	to	IN
cord-022353-q2k2krnm	735	8	human	human	JJ
cord-022353-q2k2krnm	735	9	IL-21	IL-21	NNP
cord-022353-q2k2krnm	735	10	.	.	.
cord-022353-q2k2krnm	736	1	The	the	DT
cord-022353-q2k2krnm	736	2	IL-21	IL-21	NNP
cord-022353-q2k2krnm	736	3	receptor	receptor	NN
cord-022353-q2k2krnm	736	4	utilizes	utilize	VBZ
cord-022353-q2k2krnm	736	5	the	the	DT
cord-022353-q2k2krnm	736	6	common	common	JJ
cord-022353-q2k2krnm	736	7	7-chain	7-chain	CD
cord-022353-q2k2krnm	736	8	.	.	.
cord-022353-q2k2krnm	737	1	IL-21	IL-21	NNP
cord-022353-q2k2krnm	737	2	is	be	VBZ
cord-022353-q2k2krnm	737	3	produced	produce	VBN
cord-022353-q2k2krnm	737	4	by	by	IN
cord-022353-q2k2krnm	737	5	the	the	DT
cord-022353-q2k2krnm	737	6	TH2	TH2	NNP
cord-022353-q2k2krnm	737	7	cells	cell	NNS
cord-022353-q2k2krnm	737	8	.	.	.
cord-022353-q2k2krnm	738	1	The	the	DT
cord-022353-q2k2krnm	738	2	actions	action	NNS
cord-022353-q2k2krnm	738	3	of	of	IN
cord-022353-q2k2krnm	738	4	IL-21	IL-21	NNP
cord-022353-q2k2krnm	738	5	are	be	VBP
cord-022353-q2k2krnm	738	6	pleiotropic	pleiotropic	JJ
cord-022353-q2k2krnm	738	7	and	and	CC
cord-022353-q2k2krnm	738	8	seen	see	VBN
cord-022353-q2k2krnm	738	9	on	on	IN
cord-022353-q2k2krnm	738	10	B	b	NN
cord-022353-q2k2krnm	738	11	cells	cell	NNS
cord-022353-q2k2krnm	738	12	,	,	,
cord-022353-q2k2krnm	738	13	T	t	NN
cord-022353-q2k2krnm	738	14	cells	cell	NNS
cord-022353-q2k2krnm	738	15	,	,	,
cord-022353-q2k2krnm	738	16	NK	NK	NNP
cord-022353-q2k2krnm	738	17	cells	cell	NNS
cord-022353-q2k2krnm	738	18	,	,	,
cord-022353-q2k2krnm	738	19	and	and	CC
cord-022353-q2k2krnm	738	20	dendritic	dendritic	JJ
cord-022353-q2k2krnm	738	21	cells	cell	NNS
cord-022353-q2k2krnm	738	22	.	.	.
cord-022353-q2k2krnm	739	1	IL-21	IL-21	NNP
cord-022353-q2k2krnm	739	2	induces	induce	VBZ
cord-022353-q2k2krnm	739	3	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	739	4	in	in	IN
cord-022353-q2k2krnm	739	5	resting	rest	VBG
cord-022353-q2k2krnm	739	6	and	and	CC
cord-022353-q2k2krnm	739	7	activated	activate	VBN
cord-022353-q2k2krnm	739	8	B	b	NN
cord-022353-q2k2krnm	739	9	cells	cell	NNS
cord-022353-q2k2krnm	739	10	,	,	,
cord-022353-q2k2krnm	739	11	an	an	DT
cord-022353-q2k2krnm	739	12	effect	effect	NN
cord-022353-q2k2krnm	739	13	counteracted	counteract	VBN
cord-022353-q2k2krnm	739	14	by	by	IN
cord-022353-q2k2krnm	739	15	activation	activation	NN
cord-022353-q2k2krnm	739	16	of	of	IN
cord-022353-q2k2krnm	739	17	CD40	CD40	NNP
cord-022353-q2k2krnm	739	18	.	.	.
cord-022353-q2k2krnm	740	1	It	-PRON-	PRP
cord-022353-q2k2krnm	740	2	also	also	RB
cord-022353-q2k2krnm	740	3	upregulates	upregulate	VBZ
cord-022353-q2k2krnm	740	4	production	production	NN
cord-022353-q2k2krnm	740	5	of	of	IN
cord-022353-q2k2krnm	740	6	IgG1	IgG1	NNP
cord-022353-q2k2krnm	740	7	and	and	CC
cord-022353-q2k2krnm	740	8	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	740	9	IgE	IgE	NNP
cord-022353-q2k2krnm	740	10	,	,	,
cord-022353-q2k2krnm	740	11	in	in	IN
cord-022353-q2k2krnm	740	12	fact	fact	NN
cord-022353-q2k2krnm	740	13	it	-PRON-	PRP
cord-022353-q2k2krnm	740	14	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	740	15	many	many	JJ
cord-022353-q2k2krnm	740	16	IL-4	IL-4	NNP
cord-022353-q2k2krnm	740	17	activities	activity	NNS
cord-022353-q2k2krnm	740	18	.	.	.
cord-022353-q2k2krnm	741	1	IL-21	IL-21	NNP
cord-022353-q2k2krnm	741	2	also	also	RB
cord-022353-q2k2krnm	741	3	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	741	4	dendritic	dendritic	JJ
cord-022353-q2k2krnm	741	5	cell	cell	NN
cord-022353-q2k2krnm	741	6	differentiation	differentiation	NN
cord-022353-q2k2krnm	741	7	.	.	.
cord-022353-q2k2krnm	742	1	IL-21	IL-21	NNP
cord-022353-q2k2krnm	742	2	enhances	enhance	VBZ
cord-022353-q2k2krnm	742	3	the	the	DT
cord-022353-q2k2krnm	742	4	activity	activity	NN
cord-022353-q2k2krnm	742	5	of	of	IN
cord-022353-q2k2krnm	742	6	activated	activate	VBN
cord-022353-q2k2krnm	742	7	NK	NK	NNP
cord-022353-q2k2krnm	742	8	cells	cell	NNS
cord-022353-q2k2krnm	742	9	and	and	CC
cord-022353-q2k2krnm	742	10	mediates	mediate	VBZ
cord-022353-q2k2krnm	742	11	the	the	DT
cord-022353-q2k2krnm	742	12	proliferation	proliferation	NN
cord-022353-q2k2krnm	742	13	and	and	CC
cord-022353-q2k2krnm	742	14	expansion	expansion	NN
cord-022353-q2k2krnm	742	15	of	of	IN
cord-022353-q2k2krnm	742	16	T	t	NN
cord-022353-q2k2krnm	742	17	-	-	HYPH
cord-022353-q2k2krnm	742	18	cell	cell	NN
cord-022353-q2k2krnm	742	19	subsets	subset	NNS
cord-022353-q2k2krnm	742	20	.	.	.
cord-022353-q2k2krnm	743	1	IL-22	IL-22	NNP
cord-022353-q2k2krnm	743	2	induces	induce	VBZ
cord-022353-q2k2krnm	743	3	acute	acute	JJ
cord-022353-q2k2krnm	743	4	phase	phase	NN
cord-022353-q2k2krnm	743	5	reactants	reactant	NNS
cord-022353-q2k2krnm	743	6	by	by	IN
cord-022353-q2k2krnm	743	7	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	743	8	and	and	CC
cord-022353-q2k2krnm	743	9	reduces	reduce	VBZ
cord-022353-q2k2krnm	743	10	IL-4	IL-4	NNP
cord-022353-q2k2krnm	743	11	production	production	NN
cord-022353-q2k2krnm	743	12	by	by	IN
cord-022353-q2k2krnm	743	13	TH2	TH2	NNP
cord-022353-q2k2krnm	743	14	(	(	-LRB-
cord-022353-q2k2krnm	743	15	Mehta	Mehta	NNP
cord-022353-q2k2krnm	743	16	et	et	NNP
cord-022353-q2k2krnm	743	17	al	al	NNP
cord-022353-q2k2krnm	743	18	.	.	.
cord-022353-q2k2krnm	743	19	2004	2004	CD
cord-022353-q2k2krnm	743	20	)	)	-RRB-
cord-022353-q2k2krnm	743	21	.	.	.
cord-022353-q2k2krnm	744	1	Recombinant	recombinant	JJ
cord-022353-q2k2krnm	744	2	antigens	antigen	NNS
cord-022353-q2k2krnm	744	3	and	and	CC
cord-022353-q2k2krnm	744	4	antibodies	antibody	NNS
cord-022353-q2k2krnm	744	5	are	be	VBP
cord-022353-q2k2krnm	744	6	commercially	commercially	RB
cord-022353-q2k2krnm	744	7	available	available	JJ
cord-022353-q2k2krnm	744	8	for	for	IN
cord-022353-q2k2krnm	744	9	murine	murine	JJ
cord-022353-q2k2krnm	744	10	IL-20	IL-20	NNP
cord-022353-q2k2krnm	744	11	,	,	,
cord-022353-q2k2krnm	744	12	IL-21	IL-21	NNP
cord-022353-q2k2krnm	744	13	,	,	,
cord-022353-q2k2krnm	744	14	and	and	CC
cord-022353-q2k2krnm	744	15	IL-22	IL-22	NNP
cord-022353-q2k2krnm	744	16	.	.	.
cord-022353-q2k2krnm	745	1	b.	b.	NNP
cord-022353-q2k2krnm	746	1	THE	the	DT
cord-022353-q2k2krnm	746	2	TRANSFORMING	transforming	NN
cord-022353-q2k2krnm	747	1	GROWTH	growth	NN
cord-022353-q2k2krnm	747	2	FACTOR-~	FACTOR-~	NNP
cord-022353-q2k2krnm	747	3	SUPERFAMILY	SUPERFAMILY	NNP
cord-022353-q2k2krnm	747	4	(	(	-LRB-
cord-022353-q2k2krnm	747	5	TGF-~SF	tgf-~sf	NN
cord-022353-q2k2krnm	747	6	)	)	-RRB-
cord-022353-q2k2krnm	747	7	OF	of	IN
cord-022353-q2k2krnm	747	8	CYTOI	CYTOI	NNP
cord-022353-q2k2krnm	748	1	~NES	~nes	DT
cord-022353-q2k2krnm	748	2	Members	member	NNS
cord-022353-q2k2krnm	748	3	of	of	IN
cord-022353-q2k2krnm	748	4	TGF-~	TGF-~	NNP
cord-022353-q2k2krnm	748	5	family	family	NN
cord-022353-q2k2krnm	748	6	share	share	VBP
cord-022353-q2k2krnm	748	7	25	25	CD
cord-022353-q2k2krnm	748	8	-	-	SYM
cord-022353-q2k2krnm	748	9	40	40	CD
cord-022353-q2k2krnm	748	10	%	%	NN
cord-022353-q2k2krnm	748	11	sequence	sequence	NN
cord-022353-q2k2krnm	748	12	homology	homology	NN
cord-022353-q2k2krnm	748	13	with	with	IN
cord-022353-q2k2krnm	748	14	TFG-~I	tfg-~i	CD
cord-022353-q2k2krnm	748	15	and	and	CC
cord-022353-q2k2krnm	748	16	a	a	DT
cord-022353-q2k2krnm	748	17	monomeric	monomeric	JJ
cord-022353-q2k2krnm	748	18	structure	structure	NN
cord-022353-q2k2krnm	748	19	that	that	WDT
cord-022353-q2k2krnm	748	20	consists	consist	VBZ
cord-022353-q2k2krnm	748	21	of	of	IN
cord-022353-q2k2krnm	748	22	two	two	CD
cord-022353-q2k2krnm	748	23	antiparallel	antiparallel	JJ
cord-022353-q2k2krnm	748	24	pairs	pair	NNS
cord-022353-q2k2krnm	748	25	of	of	IN
cord-022353-q2k2krnm	748	26	[	[	-LRB-
cord-022353-q2k2krnm	748	27	3-strands	3-strands	CD
cord-022353-q2k2krnm	748	28	forming	form	VBG
cord-022353-q2k2krnm	748	29	a	a	DT
cord-022353-q2k2krnm	748	30	flat	flat	JJ
cord-022353-q2k2krnm	748	31	curved	curved	JJ
cord-022353-q2k2krnm	748	32	surface	surface	NN
cord-022353-q2k2krnm	748	33	,	,	,
cord-022353-q2k2krnm	748	34	a	a	DT
cord-022353-q2k2krnm	748	35	separate	separate	JJ
cord-022353-q2k2krnm	748	36	long	long	JJ
cord-022353-q2k2krnm	748	37	cz	cz	NN
cord-022353-q2k2krnm	748	38	-	-	HYPH
cord-022353-q2k2krnm	748	39	helix	helix	NNP
cord-022353-q2k2krnm	748	40	,	,	,
cord-022353-q2k2krnm	748	41	and	and	CC
cord-022353-q2k2krnm	748	42	a	a	DT
cord-022353-q2k2krnm	748	43	disulfide	disulfide	JJ
cord-022353-q2k2krnm	748	44	rich	rich	JJ
cord-022353-q2k2krnm	748	45	core	core	NN
cord-022353-q2k2krnm	748	46	with	with	IN
cord-022353-q2k2krnm	748	47	a	a	DT
cord-022353-q2k2krnm	748	48	characteristic	characteristic	JJ
cord-022353-q2k2krnm	748	49	cysteine	cysteine	NN
cord-022353-q2k2krnm	748	50	knot	knot	NN
cord-022353-q2k2krnm	748	51	.	.	.
cord-022353-q2k2krnm	749	1	Most	Most	JJS
cord-022353-q2k2krnm	749	2	TGF-~SF	tgf-~sf	NN
cord-022353-q2k2krnm	749	3	members	member	NNS
cord-022353-q2k2krnm	749	4	are	be	VBP
cord-022353-q2k2krnm	749	5	disulfide	disulfide	RB
cord-022353-q2k2krnm	749	6	-	-	HYPH
cord-022353-q2k2krnm	749	7	linked	link	VBN
cord-022353-q2k2krnm	749	8	homodimers	homodimer	NNS
cord-022353-q2k2krnm	749	9	;	;	:
cord-022353-q2k2krnm	749	10	however	however	RB
cord-022353-q2k2krnm	749	11	,	,	,
cord-022353-q2k2krnm	749	12	three	three	CD
cord-022353-q2k2krnm	749	13	members	member	NNS
cord-022353-q2k2krnm	749	14	lack	lack	VBP
cord-022353-q2k2krnm	749	15	the	the	DT
cord-022353-q2k2krnm	749	16	seventh	seventh	JJ
cord-022353-q2k2krnm	749	17	conserved	conserved	JJ
cord-022353-q2k2krnm	749	18	cysteine	cysteine	NN
cord-022353-q2k2krnm	749	19	residue	residue	NN
cord-022353-q2k2krnm	749	20	and	and	CC
cord-022353-q2k2krnm	749	21	are	be	VBP
cord-022353-q2k2krnm	749	22	not	not	RB
cord-022353-q2k2krnm	749	23	covalent	covalent	JJ
cord-022353-q2k2krnm	749	24	homodimers	homodimer	NNS
cord-022353-q2k2krnm	749	25	.	.	.
cord-022353-q2k2krnm	750	1	Members	member	NNS
cord-022353-q2k2krnm	750	2	of	of	IN
cord-022353-q2k2krnm	750	3	the	the	DT
cord-022353-q2k2krnm	750	4	TGF-[3SF	tgf-[3sf	CD
cord-022353-q2k2krnm	750	5	include	include	VBP
cord-022353-q2k2krnm	750	6	TGF-[31	tgf-[31	NN
cord-022353-q2k2krnm	750	7	,	,	,
cord-022353-q2k2krnm	750	8	TGF-132	tgf-132	CD
cord-022353-q2k2krnm	750	9	,	,	,
cord-022353-q2k2krnm	750	10	TGF-133	tgf-133	NN
cord-022353-q2k2krnm	750	11	,	,	,
cord-022353-q2k2krnm	750	12	activins	activins	NNP
cord-022353-q2k2krnm	750	13	,	,	,
cord-022353-q2k2krnm	750	14	inhibins	inhibin	NNS
cord-022353-q2k2krnm	750	15	,	,	,
cord-022353-q2k2krnm	750	16	bone	bone	NN
cord-022353-q2k2krnm	750	17	morphogenic	morphogenic	JJ
cord-022353-q2k2krnm	750	18	proteins	protein	NNS
cord-022353-q2k2krnm	750	19	(	(	-LRB-
cord-022353-q2k2krnm	750	20	BMP	BMP	NNP
cord-022353-q2k2krnm	750	21	)	)	-RRB-
cord-022353-q2k2krnm	750	22	,	,	,
cord-022353-q2k2krnm	750	23	growth	growth	NN
cord-022353-q2k2krnm	750	24	differentiation	differentiation	NN
cord-022353-q2k2krnm	750	25	factors	factor	NNS
cord-022353-q2k2krnm	750	26	(	(	-LRB-
cord-022353-q2k2krnm	750	27	GDF	GDF	NNP
cord-022353-q2k2krnm	750	28	)	)	-RRB-
cord-022353-q2k2krnm	750	29	,	,	,
cord-022353-q2k2krnm	750	30	glial	glial	NN
cord-022353-q2k2krnm	750	31	-	-	HYPH
cord-022353-q2k2krnm	750	32	derived	derive	VBN
cord-022353-q2k2krnm	750	33	neutrophic	neutrophic	JJ
cord-022353-q2k2krnm	750	34	factors	factor	NNS
cord-022353-q2k2krnm	750	35	(	(	-LRB-
cord-022353-q2k2krnm	750	36	GDNF	GDNF	NNP
cord-022353-q2k2krnm	750	37	)	)	-RRB-
cord-022353-q2k2krnm	750	38	,	,	,
cord-022353-q2k2krnm	750	39	and	and	CC
cord-022353-q2k2krnm	750	40	mtillerian	mtillerian	JJ
cord-022353-q2k2krnm	750	41	inhibiting	inhibit	VBG
cord-022353-q2k2krnm	750	42	substance	substance	NN
cord-022353-q2k2krnm	750	43	(	(	-LRB-
cord-022353-q2k2krnm	750	44	MIS	MIS	NNP
cord-022353-q2k2krnm	750	45	)	)	-RRB-
cord-022353-q2k2krnm	750	46	.	.	.
cord-022353-q2k2krnm	751	1	TGF-[31	tgf-[31	JJ
cord-022353-q2k2krnm	751	2	is	be	VBZ
cord-022353-q2k2krnm	751	3	stimulatory	stimulatory	JJ
cord-022353-q2k2krnm	751	4	for	for	IN
cord-022353-q2k2krnm	751	5	cells	cell	NNS
cord-022353-q2k2krnm	751	6	of	of	IN
cord-022353-q2k2krnm	751	7	mesenchymal	mesenchymal	JJ
cord-022353-q2k2krnm	751	8	origin	origin	NN
cord-022353-q2k2krnm	751	9	and	and	CC
cord-022353-q2k2krnm	751	10	inhibitory	inhibitory	JJ
cord-022353-q2k2krnm	751	11	for	for	IN
cord-022353-q2k2krnm	751	12	cells	cell	NNS
cord-022353-q2k2krnm	751	13	of	of	IN
cord-022353-q2k2krnm	751	14	epithelial	epithelial	JJ
cord-022353-q2k2krnm	751	15	or	or	CC
cord-022353-q2k2krnm	751	16	neuroectodermal	neuroectodermal	JJ
cord-022353-q2k2krnm	751	17	origin	origin	NN
cord-022353-q2k2krnm	751	18	.	.	.
cord-022353-q2k2krnm	752	1	In	in	IN
cord-022353-q2k2krnm	752	2	the	the	DT
cord-022353-q2k2krnm	752	3	murine	murine	JJ
cord-022353-q2k2krnm	752	4	immune	immune	JJ
cord-022353-q2k2krnm	752	5	system	system	NN
cord-022353-q2k2krnm	752	6	TGF-[31	tgf-[31	RB
cord-022353-q2k2krnm	752	7	is	be	VBZ
cord-022353-q2k2krnm	752	8	the	the	DT
cord-022353-q2k2krnm	752	9	mediator	mediator	NN
cord-022353-q2k2krnm	752	10	of	of	IN
cord-022353-q2k2krnm	752	11	immune	immune	JJ
cord-022353-q2k2krnm	752	12	suppression	suppression	NN
cord-022353-q2k2krnm	752	13	via	via	IN
cord-022353-q2k2krnm	752	14	CD4+CD25+Tr	cd4+cd25+tr	JJ
cord-022353-q2k2krnm	752	15	cells	cell	NNS
cord-022353-q2k2krnm	752	16	and	and	CC
cord-022353-q2k2krnm	752	17	,	,	,
cord-022353-q2k2krnm	752	18	at	at	IN
cord-022353-q2k2krnm	752	19	least	least	JJS
cord-022353-q2k2krnm	752	20	in	in	IN
cord-022353-q2k2krnm	752	21	the	the	DT
cord-022353-q2k2krnm	752	22	case	case	NN
cord-022353-q2k2krnm	752	23	of	of	IN
cord-022353-q2k2krnm	752	24	suppressing	suppress	VBG
cord-022353-q2k2krnm	752	25	CD8	CD8	NNP
cord-022353-q2k2krnm	752	26	+	+	CC
cord-022353-q2k2krnm	752	27	effector	effector	VB
cord-022353-q2k2krnm	752	28	T	t	NN
cord-022353-q2k2krnm	752	29	cells	cell	NNS
cord-022353-q2k2krnm	752	30	,	,	,
cord-022353-q2k2krnm	752	31	involves	involve	VBZ
cord-022353-q2k2krnm	753	1	TGF-[3	TGF-[3	NNP
cord-022353-q2k2krnm	753	2	receptor	receptor	NN
cord-022353-q2k2krnm	753	3	II	II	NNP
cord-022353-q2k2krnm	753	4	on	on	IN
cord-022353-q2k2krnm	753	5	these	these	DT
cord-022353-q2k2krnm	753	6	cells	cell	NNS
cord-022353-q2k2krnm	753	7	(	(	-LRB-
cord-022353-q2k2krnm	753	8	Powrie	Powrie	NNP
cord-022353-q2k2krnm	753	9	2004	2004	CD
cord-022353-q2k2krnm	753	10	;	;	:
cord-022353-q2k2krnm	753	11	von	von	NNP
cord-022353-q2k2krnm	753	12	Boehmer	Boehmer	NNP
cord-022353-q2k2krnm	753	13	2005	2005	CD
cord-022353-q2k2krnm	753	14	)	)	-RRB-
cord-022353-q2k2krnm	753	15	.	.	.
cord-022353-q2k2krnm	754	1	In	in	IN
cord-022353-q2k2krnm	754	2	addition	addition	NN
cord-022353-q2k2krnm	754	3	TGF-[3	TGF-[3	NNP
cord-022353-q2k2krnm	754	4	is	be	VBZ
cord-022353-q2k2krnm	754	5	known	know	VBN
cord-022353-q2k2krnm	754	6	to	to	TO
cord-022353-q2k2krnm	754	7	inhibit	inhibit	VB
cord-022353-q2k2krnm	754	8	B	b	NN
cord-022353-q2k2krnm	754	9	-	-	HYPH
cord-022353-q2k2krnm	754	10	cell	cell	NN
cord-022353-q2k2krnm	754	11	proliferation	proliferation	NN
cord-022353-q2k2krnm	754	12	and	and	CC
cord-022353-q2k2krnm	754	13	it	-PRON-	PRP
cord-022353-q2k2krnm	754	14	promotes	promote	VBZ
cord-022353-q2k2krnm	754	15	isotype	isotype	NN
cord-022353-q2k2krnm	754	16	switch	switch	NN
cord-022353-q2k2krnm	754	17	to	to	IN
cord-022353-q2k2krnm	754	18	IgA.	IgA.	NNP
cord-022353-q2k2krnm	755	1	Oral	oral	JJ
cord-022353-q2k2krnm	755	2	tolerance	tolerance	NN
cord-022353-q2k2krnm	755	3	to	to	IN
cord-022353-q2k2krnm	755	4	TH2	TH2	NNP
cord-022353-q2k2krnm	755	5	responses	response	NNS
cord-022353-q2k2krnm	755	6	(	(	-LRB-
cord-022353-q2k2krnm	755	7	against	against	IN
cord-022353-q2k2krnm	755	8	food	food	NN
cord-022353-q2k2krnm	755	9	allergins	allergin	NNS
cord-022353-q2k2krnm	755	10	)	)	-RRB-
cord-022353-q2k2krnm	755	11	is	be	VBZ
cord-022353-q2k2krnm	755	12	mediated	mediate	VBN
cord-022353-q2k2krnm	755	13	by	by	IN
cord-022353-q2k2krnm	755	14	TGF-~I1	tgf-~i1	CD
cord-022353-q2k2krnm	755	15	(	(	-LRB-
cord-022353-q2k2krnm	755	16	Mucida	Mucida	NNP
cord-022353-q2k2krnm	755	17	et	et	NNP
cord-022353-q2k2krnm	755	18	al	al	NNP
cord-022353-q2k2krnm	755	19	.	.	NNP
cord-022353-q2k2krnm	755	20	2005	2005	CD
cord-022353-q2k2krnm	755	21	)	)	-RRB-
cord-022353-q2k2krnm	755	22	.	.	.
cord-022353-q2k2krnm	756	1	TGF-[3	TGF-[3	NNP
cord-022353-q2k2krnm	756	2	has	have	VBZ
cord-022353-q2k2krnm	756	3	a	a	DT
cord-022353-q2k2krnm	756	4	wide	wide	JJ
cord-022353-q2k2krnm	756	5	range	range	NN
cord-022353-q2k2krnm	756	6	of	of	IN
cord-022353-q2k2krnm	756	7	effects	effect	NNS
cord-022353-q2k2krnm	756	8	on	on	IN
cord-022353-q2k2krnm	756	9	cell	cell	NN
cord-022353-q2k2krnm	756	10	growth	growth	NN
cord-022353-q2k2krnm	756	11	differentiation	differentiation	NN
cord-022353-q2k2krnm	756	12	and	and	CC
cord-022353-q2k2krnm	756	13	malignant	malignant	JJ
cord-022353-q2k2krnm	756	14	transformation	transformation	NN
cord-022353-q2k2krnm	756	15	(	(	-LRB-
cord-022353-q2k2krnm	756	16	Letterio	Letterio	NNP
cord-022353-q2k2krnm	756	17	2005	2005	CD
cord-022353-q2k2krnm	756	18	)	)	-RRB-
cord-022353-q2k2krnm	756	19	.	.	.
cord-022353-q2k2krnm	757	1	Murine	murine	JJ
cord-022353-q2k2krnm	757	2	TGF-~I	TGF-~I	NNP
cord-022353-q2k2krnm	757	3	1	1	CD
cord-022353-q2k2krnm	757	4	may	may	MD
cord-022353-q2k2krnm	757	5	be	be	VB
cord-022353-q2k2krnm	757	6	quantified	quantify	VBN
cord-022353-q2k2krnm	757	7	in	in	IN
cord-022353-q2k2krnm	757	8	serum	serum	NN
cord-022353-q2k2krnm	757	9	or	or	CC
cord-022353-q2k2krnm	757	10	plasma	plasma	NN
cord-022353-q2k2krnm	757	11	using	use	VBG
cord-022353-q2k2krnm	757	12	commercially	commercially	RB
cord-022353-q2k2krnm	757	13	available	available	JJ
cord-022353-q2k2krnm	757	14	ELISA	ELISA	NNP
cord-022353-q2k2krnm	757	15	kits	kit	NNS
cord-022353-q2k2krnm	757	16	.	.	.
cord-022353-q2k2krnm	758	1	Antibodies	antibody	NNS
cord-022353-q2k2krnm	758	2	are	be	VBP
cord-022353-q2k2krnm	758	3	also	also	RB
cord-022353-q2k2krnm	758	4	available	available	JJ
cord-022353-q2k2krnm	758	5	which	which	WDT
cord-022353-q2k2krnm	758	6	specifically	specifically	RB
cord-022353-q2k2krnm	758	7	bind	bind	VBP
cord-022353-q2k2krnm	758	8	murine	murine	JJ
cord-022353-q2k2krnm	758	9	BMP	BMP	NNP
cord-022353-q2k2krnm	758	10	,	,	,
cord-022353-q2k2krnm	758	11	activin	activin	NNP
cord-022353-q2k2krnm	758	12	A	A	NNP
cord-022353-q2k2krnm	758	13	,	,	,
cord-022353-q2k2krnm	758	14	activin	activin	NNP
cord-022353-q2k2krnm	758	15	C	C	NNP
cord-022353-q2k2krnm	758	16	,	,	,
cord-022353-q2k2krnm	758	17	and	and	CC
cord-022353-q2k2krnm	758	18	GDF-1,-3,-5,-8	GDF-1,-3,-5,-8	NNS
cord-022353-q2k2krnm	758	19	,	,	,
cord-022353-q2k2krnm	759	1	and-9	and-9	FW
cord-022353-q2k2krnm	759	2	,	,	,
cord-022353-q2k2krnm	759	3	although	although	IN
cord-022353-q2k2krnm	759	4	they	-PRON-	PRP
cord-022353-q2k2krnm	759	5	are	be	VBP
cord-022353-q2k2krnm	759	6	not	not	RB
cord-022353-q2k2krnm	759	7	recommended	recommend	VBN
cord-022353-q2k2krnm	759	8	for	for	IN
cord-022353-q2k2krnm	759	9	ELISA	ELISA	NNP
cord-022353-q2k2krnm	759	10	development	development	NN
cord-022353-q2k2krnm	759	11	.	.	.
cord-022353-q2k2krnm	760	1	C.	C.	NNP
cord-022353-q2k2krnm	761	1	THE	the	DT
cord-022353-q2k2krnm	761	2	TUMOR	tumor	NN
cord-022353-q2k2krnm	761	3	NECROSIS	necrosis	NN
cord-022353-q2k2krnm	761	4	FACTOR	factor	NN
cord-022353-q2k2krnm	761	5	SUPERFAMILY	SUPERFAMILY	NNP
cord-022353-q2k2krnm	761	6	(	(	-LRB-
cord-022353-q2k2krnm	761	7	TNFSF	TNFSF	NNP
cord-022353-q2k2krnm	761	8	)	)	-RRB-
cord-022353-q2k2krnm	761	9	TNF	tnf	NN
cord-022353-q2k2krnm	761	10	-	-	HYPH
cord-022353-q2k2krnm	761	11	related	relate	VBN
cord-022353-q2k2krnm	761	12	ligands	ligand	NNS
cord-022353-q2k2krnm	761	13	share	share	VBP
cord-022353-q2k2krnm	761	14	many	many	JJ
cord-022353-q2k2krnm	761	15	features	feature	NNS
cord-022353-q2k2krnm	761	16	but	but	CC
cord-022353-q2k2krnm	761	17	high	high	JJ
cord-022353-q2k2krnm	761	18	amino	amino	NN
cord-022353-q2k2krnm	761	19	acid	acid	NN
cord-022353-q2k2krnm	761	20	sequence	sequence	NN
cord-022353-q2k2krnm	761	21	homology	homology	NN
cord-022353-q2k2krnm	761	22	is	be	VBZ
cord-022353-q2k2krnm	761	23	not	not	RB
cord-022353-q2k2krnm	761	24	one	one	CD
cord-022353-q2k2krnm	761	25	of	of	IN
cord-022353-q2k2krnm	761	26	them	-PRON-	PRP
cord-022353-q2k2krnm	761	27	.	.	.
cord-022353-q2k2krnm	762	1	With	with	IN
cord-022353-q2k2krnm	762	2	the	the	DT
cord-022353-q2k2krnm	762	3	exception	exception	NN
cord-022353-q2k2krnm	762	4	of	of	IN
cord-022353-q2k2krnm	762	5	nerve	nerve	NN
cord-022353-q2k2krnm	762	6	growth	growth	NN
cord-022353-q2k2krnm	762	7	factor	factor	NN
cord-022353-q2k2krnm	762	8	and	and	CC
cord-022353-q2k2krnm	762	9	TNF-~	TNF-~	NNP
cord-022353-q2k2krnm	762	10	,	,	,
cord-022353-q2k2krnm	762	11	all	all	DT
cord-022353-q2k2krnm	762	12	ligands	ligand	NNS
cord-022353-q2k2krnm	762	13	are	be	VBP
cord-022353-q2k2krnm	762	14	type	type	NN
cord-022353-q2k2krnm	762	15	Ii	Ii	NNP
cord-022353-q2k2krnm	762	16	traMsmembrane	tramsmembrane	NN
cord-022353-q2k2krnm	762	17	proteins	protein	NNS
cord-022353-q2k2krnm	762	18	(	(	-LRB-
cord-022353-q2k2krnm	762	19	extracellular	extracellular	JJ
cord-022353-q2k2krnm	762	20	C	c	NN
cord-022353-q2k2krnm	762	21	-	-	HYPH
cord-022353-q2k2krnm	762	22	terminus	terminus	NN
cord-022353-q2k2krnm	762	23	)	)	-RRB-
cord-022353-q2k2krnm	762	24	that	that	WDT
cord-022353-q2k2krnm	762	25	contain	contain	VBP
cord-022353-q2k2krnm	762	26	a	a	DT
cord-022353-q2k2krnm	762	27	short	short	JJ
cord-022353-q2k2krnm	762	28	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	762	29	segment	segment	NN
cord-022353-q2k2krnm	762	30	and	and	CC
cord-022353-q2k2krnm	762	31	a	a	DT
cord-022353-q2k2krnm	762	32	long	long	JJ
cord-022353-q2k2krnm	762	33	extracellular	extracellular	JJ
cord-022353-q2k2krnm	762	34	region	region	NN
cord-022353-q2k2krnm	762	35	.	.	.
cord-022353-q2k2krnm	763	1	TNF-~	TNF-~	NNP
cord-022353-q2k2krnm	763	2	is	be	VBZ
cord-022353-q2k2krnm	763	3	fully	fully	RB
cord-022353-q2k2krnm	763	4	secreted	secrete	VBN
cord-022353-q2k2krnm	763	5	and	and	CC
cord-022353-q2k2krnm	763	6	has	have	VBZ
cord-022353-q2k2krnm	763	7	a	a	DT
cord-022353-q2k2krnm	763	8	nonfunctional	nonfunctional	JJ
cord-022353-q2k2krnm	763	9	transmembrane	transmembrane	NN
cord-022353-q2k2krnm	763	10	segment	segment	NN
cord-022353-q2k2krnm	763	11	.	.	.
cord-022353-q2k2krnm	764	1	TNFSF	TNFSF	NNP
cord-022353-q2k2krnm	764	2	members	member	NNS
cord-022353-q2k2krnm	764	3	form	form	VBP
cord-022353-q2k2krnm	764	4	trimeric	trimeric	JJ
cord-022353-q2k2krnm	764	5	structures	structure	NNS
cord-022353-q2k2krnm	764	6	and	and	CC
cord-022353-q2k2krnm	764	7	their	-PRON-	PRP$
cord-022353-q2k2krnm	764	8	monomers	monomer	NNS
cord-022353-q2k2krnm	764	9	are	be	VBP
cord-022353-q2k2krnm	764	10	composed	compose	VBN
cord-022353-q2k2krnm	764	11	of	of	IN
cord-022353-q2k2krnm	764	12	~-strands	~-strand	NNS
cord-022353-q2k2krnm	764	13	oriented	orient	VBN
cord-022353-q2k2krnm	764	14	into	into	IN
cord-022353-q2k2krnm	764	15	a	a	DT
cord-022353-q2k2krnm	764	16	twosheet	twosheet	NN
cord-022353-q2k2krnm	764	17	structure	structure	NN
cord-022353-q2k2krnm	764	18	.	.	.
cord-022353-q2k2krnm	765	1	Receptors	receptor	NNS
cord-022353-q2k2krnm	765	2	for	for	IN
cord-022353-q2k2krnm	765	3	the	the	DT
cord-022353-q2k2krnm	765	4	TNFSF	TNFSF	NNP
cord-022353-q2k2krnm	765	5	ligands	ligand	NNS
cord-022353-q2k2krnm	765	6	also	also	RB
cord-022353-q2k2krnm	765	7	belong	belong	VBP
cord-022353-q2k2krnm	765	8	to	to	IN
cord-022353-q2k2krnm	765	9	a	a	DT
cord-022353-q2k2krnm	765	10	superfamily	superfamily	NN
cord-022353-q2k2krnm	765	11	,	,	,
cord-022353-q2k2krnm	765	12	TNFRSF	TNFRSF	NNP
cord-022353-q2k2krnm	765	13	(	(	-LRB-
cord-022353-q2k2krnm	765	14	Gruss	Gruss	NNP
cord-022353-q2k2krnm	765	15	and	and	CC
cord-022353-q2k2krnm	765	16	Dower	Dower	NNP
cord-022353-q2k2krnm	765	17	1995	1995	CD
cord-022353-q2k2krnm	765	18	)	)	-RRB-
cord-022353-q2k2krnm	765	19	,	,	,
cord-022353-q2k2krnm	765	20	and	and	CC
cord-022353-q2k2krnm	765	21	are	be	VBP
cord-022353-q2k2krnm	765	22	characterized	characterize	VBN
cord-022353-q2k2krnm	765	23	as	as	IN
cord-022353-q2k2krnm	765	24	type	type	NN
cord-022353-q2k2krnm	765	25	I	-PRON-	PRP
cord-022353-q2k2krnm	765	26	transmembrane	transmembrane	NN
cord-022353-q2k2krnm	765	27	proteins	protein	NNS
cord-022353-q2k2krnm	765	28	(	(	-LRB-
cord-022353-q2k2krnm	765	29	with	with	IN
cord-022353-q2k2krnm	765	30	their	-PRON-	PRP$
cord-022353-q2k2krnm	765	31	amino	amino	NN
cord-022353-q2k2krnm	765	32	termini	terminus	NNS
cord-022353-q2k2krnm	765	33	outside	outside	RB
cord-022353-q2k2krnm	765	34	of	of	IN
cord-022353-q2k2krnm	765	35	the	the	DT
cord-022353-q2k2krnm	765	36	cell	cell	NN
cord-022353-q2k2krnm	765	37	)	)	-RRB-
cord-022353-q2k2krnm	765	38	,	,	,
cord-022353-q2k2krnm	765	39	with	with	IN
cord-022353-q2k2krnm	765	40	extracellular	extracellular	JJ
cord-022353-q2k2krnm	765	41	cysteine	cysteine	JJ
cord-022353-q2k2krnm	765	42	-	-	HYPH
cord-022353-q2k2krnm	765	43	rich	rich	JJ
cord-022353-q2k2krnm	765	44	structural	structural	JJ
cord-022353-q2k2krnm	765	45	motifs	motif	NNS
cord-022353-q2k2krnm	765	46	.	.	.
cord-022353-q2k2krnm	766	1	TNFRSF	TNFRSF	NNP
cord-022353-q2k2krnm	766	2	members	member	NNS
cord-022353-q2k2krnm	766	3	exist	exist	VBP
cord-022353-q2k2krnm	766	4	both	both	DT
cord-022353-q2k2krnm	766	5	as	as	IN
cord-022353-q2k2krnm	766	6	membrane	membrane	NN
cord-022353-q2k2krnm	766	7	and	and	CC
cord-022353-q2k2krnm	766	8	soluble	soluble	JJ
cord-022353-q2k2krnm	766	9	forms	form	NNS
cord-022353-q2k2krnm	766	10	.	.	.
cord-022353-q2k2krnm	767	1	Commercially	commercially	RB
cord-022353-q2k2krnm	767	2	available	available	JJ
cord-022353-q2k2krnm	767	3	ELISA	ELISA	NNP
cord-022353-q2k2krnm	767	4	kits	kit	NNS
cord-022353-q2k2krnm	767	5	or	or	CC
cord-022353-q2k2krnm	767	6	matched	match	VBN
cord-022353-q2k2krnm	767	7	antibody	antibody	NN
cord-022353-q2k2krnm	767	8	for	for	IN
cord-022353-q2k2krnm	767	9	development	development	NN
cord-022353-q2k2krnm	767	10	of	of	IN
cord-022353-q2k2krnm	767	11	assays	assay	NNS
cord-022353-q2k2krnm	767	12	are	be	VBP
cord-022353-q2k2krnm	767	13	available	available	JJ
cord-022353-q2k2krnm	767	14	to	to	TO
cord-022353-q2k2krnm	767	15	quantify	quantify	VB
cord-022353-q2k2krnm	767	16	the	the	DT
cord-022353-q2k2krnm	767	17	murine	murine	JJ
cord-022353-q2k2krnm	767	18	receptors	receptor	NNS
cord-022353-q2k2krnm	767	19	and	and	CC
cord-022353-q2k2krnm	767	20	ligands	ligand	NNS
cord-022353-q2k2krnm	767	21	of	of	IN
cord-022353-q2k2krnm	767	22	the	the	DT
cord-022353-q2k2krnm	767	23	TNFSF	TNFSF	NNP
cord-022353-q2k2krnm	767	24	discussed	discuss	VBN
cord-022353-q2k2krnm	767	25	in	in	IN
cord-022353-q2k2krnm	767	26	this	this	DT
cord-022353-q2k2krnm	767	27	section	section	NN
cord-022353-q2k2krnm	767	28	.	.	.
cord-022353-q2k2krnm	768	1	i.	i.	NNP
cord-022353-q2k2krnm	768	2	TUMOR	TUMOR	NNP
cord-022353-q2k2krnm	768	3	NECROSIS	NECROSIS	NNP
cord-022353-q2k2krnm	768	4	FACTOR	FACTOR	NNP
cord-022353-q2k2krnm	768	5	-	-	HYPH
cord-022353-q2k2krnm	768	6	IX	IX	NNP
cord-022353-q2k2krnm	768	7	(	(	-LRB-
cord-022353-q2k2krnm	768	8	TNF	TNF	NNP
cord-022353-q2k2krnm	768	9	-	-	HYPH
cord-022353-q2k2krnm	768	10	IX	IX	NNP
cord-022353-q2k2krnm	768	11	)	)	-RRB-
cord-022353-q2k2krnm	769	1	TNF	TNF	NNP
cord-022353-q2k2krnm	769	2	-	-	HYPH
cord-022353-q2k2krnm	769	3	tx	tx	NNP
cord-022353-q2k2krnm	769	4	is	be	VBZ
cord-022353-q2k2krnm	769	5	expressed	express	VBN
cord-022353-q2k2krnm	769	6	as	as	IN
cord-022353-q2k2krnm	769	7	a	a	DT
cord-022353-q2k2krnm	769	8	26-kDa	26-kda	CD
cord-022353-q2k2krnm	769	9	membrane	membrane	NN
cord-022353-q2k2krnm	769	10	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	769	11	and	and	CC
cord-022353-q2k2krnm	769	12	the	the	DT
cord-022353-q2k2krnm	769	13	soluble	soluble	JJ
cord-022353-q2k2krnm	769	14	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	769	15	is	be	VBZ
cord-022353-q2k2krnm	769	16	generated	generate	VBN
cord-022353-q2k2krnm	769	17	by	by	IN
cord-022353-q2k2krnm	769	18	proteolytic	proteolytic	JJ
cord-022353-q2k2krnm	769	19	cleavage	cleavage	NN
cord-022353-q2k2krnm	769	20	via	via	IN
cord-022353-q2k2krnm	769	21	TNF	TNF	NNP
cord-022353-q2k2krnm	769	22	-	-	HYPH
cord-022353-q2k2krnm	769	23	ct	ct	NNP
cord-022353-q2k2krnm	769	24	converting	converting	NN
cord-022353-q2k2krnm	769	25	enzyme	enzyme	NN
cord-022353-q2k2krnm	769	26	(	(	-LRB-
cord-022353-q2k2krnm	769	27	TACE	TACE	NNP
cord-022353-q2k2krnm	769	28	)	)	-RRB-
cord-022353-q2k2krnm	769	29	.	.	.
cord-022353-q2k2krnm	770	1	The	the	DT
cord-022353-q2k2krnm	770	2	17-kDa	17-kda	CD
cord-022353-q2k2krnm	770	3	homotrimer	homotrimer	NN
cord-022353-q2k2krnm	770	4	cleavage	cleavage	NN
cord-022353-q2k2krnm	770	5	product	product	NN
cord-022353-q2k2krnm	770	6	circulates	circulate	VBZ
cord-022353-q2k2krnm	770	7	.	.	.
cord-022353-q2k2krnm	771	1	Mouse	Mouse	NNP
cord-022353-q2k2krnm	771	2	TNF	TNF	NNP
cord-022353-q2k2krnm	771	3	-	-	HYPH
cord-022353-q2k2krnm	771	4	tx	tx	NNP
cord-022353-q2k2krnm	771	5	has	have	VBZ
cord-022353-q2k2krnm	771	6	79	79	CD
cord-022353-q2k2krnm	771	7	%	%	NN
cord-022353-q2k2krnm	771	8	sequence	sequence	NN
cord-022353-q2k2krnm	771	9	homology	homology	NN
cord-022353-q2k2krnm	771	10	with	with	IN
cord-022353-q2k2krnm	771	11	human	human	NN
cord-022353-q2k2krnm	771	12	.	.	.
cord-022353-q2k2krnm	772	1	TNF	TNF	NNP
cord-022353-q2k2krnm	772	2	-	-	HYPH
cord-022353-q2k2krnm	772	3	tx	tx	NNP
cord-022353-q2k2krnm	772	4	is	be	VBZ
cord-022353-q2k2krnm	772	5	expressed	express	VBN
cord-022353-q2k2krnm	772	6	widely	widely	RB
cord-022353-q2k2krnm	772	7	on	on	IN
cord-022353-q2k2krnm	772	8	tissues	tissue	NNS
cord-022353-q2k2krnm	772	9	throughout	throughout	IN
cord-022353-q2k2krnm	772	10	the	the	DT
cord-022353-q2k2krnm	772	11	body	body	NN
cord-022353-q2k2krnm	772	12	(	(	-LRB-
cord-022353-q2k2krnm	772	13	Goetz	Goetz	NNP
cord-022353-q2k2krnm	772	14	et	et	NNP
cord-022353-q2k2krnm	772	15	al	al	NNP
cord-022353-q2k2krnm	772	16	.	.	.
cord-022353-q2k2krnm	772	17	2004	2004	CD
cord-022353-q2k2krnm	772	18	)	)	-RRB-
cord-022353-q2k2krnm	772	19	.	.	.
cord-022353-q2k2krnm	773	1	TNF	TNF	NNP
cord-022353-q2k2krnm	773	2	-	-	HYPH
cord-022353-q2k2krnm	773	3	tx	tx	NNP
cord-022353-q2k2krnm	773	4	is	be	VBZ
cord-022353-q2k2krnm	773	5	a	a	DT
cord-022353-q2k2krnm	773	6	strong	strong	JJ
cord-022353-q2k2krnm	773	7	mediator	mediator	NN
cord-022353-q2k2krnm	773	8	of	of	IN
cord-022353-q2k2krnm	773	9	inflammation	inflammation	NN
cord-022353-q2k2krnm	773	10	and	and	CC
cord-022353-q2k2krnm	773	11	immune	immune	JJ
cord-022353-q2k2krnm	773	12	function	function	NN
cord-022353-q2k2krnm	773	13	,	,	,
cord-022353-q2k2krnm	773	14	or	or	CC
cord-022353-q2k2krnm	773	15	regulates	regulate	VBZ
cord-022353-q2k2krnm	773	16	on	on	IN
cord-022353-q2k2krnm	773	17	growth	growth	NN
cord-022353-q2k2krnm	773	18	and	and	CC
cord-022353-q2k2krnm	773	19	differentiation	differentiation	NN
cord-022353-q2k2krnm	773	20	,	,	,
cord-022353-q2k2krnm	773	21	and	and	CC
cord-022353-q2k2krnm	773	22	is	be	VBZ
cord-022353-q2k2krnm	773	23	cytotoxic	cytotoxic	JJ
cord-022353-q2k2krnm	773	24	for	for	IN
cord-022353-q2k2krnm	773	25	many	many	JJ
cord-022353-q2k2krnm	773	26	transformed	transform	VBN
cord-022353-q2k2krnm	773	27	cells	cell	NNS
cord-022353-q2k2krnm	773	28	.	.	.
cord-022353-q2k2krnm	774	1	ii	ii	NNP
cord-022353-q2k2krnm	774	2	iii	iii	NNP
cord-022353-q2k2krnm	774	3	.	.	.
cord-022353-q2k2krnm	775	1	CD40L	CD40L	NNP
cord-022353-q2k2krnm	775	2	CD40L	CD40L	NNP
cord-022353-q2k2krnm	776	1	(	(	-LRB-
cord-022353-q2k2krnm	776	2	TNFSF5	TNFSF5	NNP
cord-022353-q2k2krnm	776	3	,	,	,
cord-022353-q2k2krnm	776	4	CD154	CD154	NNP
cord-022353-q2k2krnm	776	5	)	)	-RRB-
cord-022353-q2k2krnm	776	6	is	be	VBZ
cord-022353-q2k2krnm	776	7	a	a	DT
cord-022353-q2k2krnm	776	8	39-kDa	39-kda	CD
cord-022353-q2k2krnm	776	9	,	,	,
cord-022353-q2k2krnm	776	10	type	type	NN
cord-022353-q2k2krnm	776	11	II	II	NNP
cord-022353-q2k2krnm	776	12	,	,	,
cord-022353-q2k2krnm	776	13	transmembrane	transmembrane	NN
cord-022353-q2k2krnm	776	14	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	776	15	that	that	WDT
cord-022353-q2k2krnm	776	16	can	can	MD
cord-022353-q2k2krnm	776	17	be	be	VB
cord-022353-q2k2krnm	776	18	proteolytically	proteolytically	RB
cord-022353-q2k2krnm	776	19	cleaved	cleave	VBN
cord-022353-q2k2krnm	776	20	to	to	IN
cord-022353-q2k2krnm	776	21	15-to	15-to	CD
cord-022353-q2k2krnm	776	22	18-kDa	18-kda	CD
cord-022353-q2k2krnm	776	23	soluble	soluble	JJ
cord-022353-q2k2krnm	776	24	forms	form	NNS
cord-022353-q2k2krnm	776	25	with	with	IN
cord-022353-q2k2krnm	776	26	full	full	JJ
cord-022353-q2k2krnm	776	27	biologic	biologic	JJ
cord-022353-q2k2krnm	776	28	activity	activity	NN
cord-022353-q2k2krnm	776	29	.	.	.
cord-022353-q2k2krnm	777	1	It	-PRON-	PRP
cord-022353-q2k2krnm	777	2	forms	form	VBZ
cord-022353-q2k2krnm	777	3	natural	natural	JJ
cord-022353-q2k2krnm	777	4	trimeric	trimeric	JJ
cord-022353-q2k2krnm	777	5	structures	structure	NNS
cord-022353-q2k2krnm	777	6	and	and	CC
cord-022353-q2k2krnm	777	7	the	the	DT
cord-022353-q2k2krnm	777	8	mouse	mouse	NN
cord-022353-q2k2krnm	778	1	CD40L	CD40L	NNP
cord-022353-q2k2krnm	778	2	shares	share	VBZ
cord-022353-q2k2krnm	778	3	73	73	CD
cord-022353-q2k2krnm	778	4	%	%	NN
cord-022353-q2k2krnm	778	5	sequence	sequence	NN
cord-022353-q2k2krnm	778	6	identity	identity	NN
cord-022353-q2k2krnm	778	7	with	with	IN
cord-022353-q2k2krnm	778	8	human	human	JJ
cord-022353-q2k2krnm	778	9	CD40L.	CD40L.	NNP
cord-022353-q2k2krnm	778	10	Cells	cell	NNS
cord-022353-q2k2krnm	778	11	expressing	express	VBG
cord-022353-q2k2krnm	778	12	CD40L	cd40l	NN
cord-022353-q2k2krnm	778	13	include	include	VBP
cord-022353-q2k2krnm	778	14	B	b	NN
cord-022353-q2k2krnm	778	15	cells	cell	NNS
cord-022353-q2k2krnm	778	16	,	,	,
cord-022353-q2k2krnm	778	17	CD4	CD4	NNP
cord-022353-q2k2krnm	778	18	+	+	CC
cord-022353-q2k2krnm	778	19	and	and	CC
cord-022353-q2k2krnm	778	20	CD8	CD8	NNP
cord-022353-q2k2krnm	778	21	§	§	:
cord-022353-q2k2krnm	778	22	T	T	NNP
cord-022353-q2k2krnm	778	23	cells	cell	NNS
cord-022353-q2k2krnm	778	24	,	,	,
cord-022353-q2k2krnm	778	25	monocytes	monocyte	NNS
cord-022353-q2k2krnm	778	26	,	,	,
cord-022353-q2k2krnm	778	27	NK	NK	NNP
cord-022353-q2k2krnm	778	28	cells	cell	NNS
cord-022353-q2k2krnm	778	29	,	,	,
cord-022353-q2k2krnm	778	30	and	and	CC
cord-022353-q2k2krnm	778	31	y	y	NNP
cord-022353-q2k2krnm	778	32	T	T	NNP
cord-022353-q2k2krnm	778	33	cells	cell	NNS
cord-022353-q2k2krnm	778	34	(	(	-LRB-
cord-022353-q2k2krnm	778	35	Toubi	Toubi	NNP
cord-022353-q2k2krnm	778	36	and	and	CC
cord-022353-q2k2krnm	778	37	Shoenfeld	Shoenfeld	NNP
cord-022353-q2k2krnm	778	38	2004	2004	CD
cord-022353-q2k2krnm	778	39	)	)	-RRB-
cord-022353-q2k2krnm	778	40	.	.	.
cord-022353-q2k2krnm	779	1	On	on	IN
cord-022353-q2k2krnm	779	2	binding	bind	VBG
cord-022353-q2k2krnm	779	3	CD40	CD40	NNP
cord-022353-q2k2krnm	779	4	,	,	,
cord-022353-q2k2krnm	779	5	the	the	DT
cord-022353-q2k2krnm	779	6	complex	complex	NN
cord-022353-q2k2krnm	779	7	initiates	initiate	VBZ
cord-022353-q2k2krnm	779	8	signals	signal	NNS
cord-022353-q2k2krnm	779	9	important	important	JJ
cord-022353-q2k2krnm	779	10	for	for	IN
cord-022353-q2k2krnm	779	11	cell	cell	NN
cord-022353-q2k2krnm	779	12	proliferation	proliferation	NN
cord-022353-q2k2krnm	779	13	or	or	CC
cord-022353-q2k2krnm	779	14	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	779	15	.	.	.
cord-022353-q2k2krnm	780	1	Cross	cross	NN
cord-022353-q2k2krnm	780	2	-	-	NN
cord-022353-q2k2krnm	780	3	linkage	linkage	NN
cord-022353-q2k2krnm	780	4	between	between	IN
cord-022353-q2k2krnm	780	5	T	t	NN
cord-022353-q2k2krnm	780	6	and	and	CC
cord-022353-q2k2krnm	780	7	B	b	NN
cord-022353-q2k2krnm	780	8	cells	cell	NNS
cord-022353-q2k2krnm	780	9	allows	allow	VBZ
cord-022353-q2k2krnm	780	10	CD40	CD40	NNP
cord-022353-q2k2krnm	780	11	to	to	TO
cord-022353-q2k2krnm	780	12	transduce	transduce	VB
cord-022353-q2k2krnm	780	13	the	the	DT
cord-022353-q2k2krnm	780	14	tyrosine	tyrosine	NN
cord-022353-q2k2krnm	780	15	kinases	kinase	NNS
cord-022353-q2k2krnm	780	16	Lyn	Lyn	NNP
cord-022353-q2k2krnm	780	17	and	and	CC
cord-022353-q2k2krnm	780	18	Syk	Syk	NNP
cord-022353-q2k2krnm	780	19	,	,	,
cord-022353-q2k2krnm	780	20	and	and	CC
cord-022353-q2k2krnm	780	21	activate	activate	VBP
cord-022353-q2k2krnm	780	22	phospholipase	phospholipase	NN
cord-022353-q2k2krnm	780	23	C	C	NNP
cord-022353-q2k2krnm	780	24	,	,	,
cord-022353-q2k2krnm	780	25	IP3	IP3	NNP
cord-022353-q2k2krnm	780	26	,	,	,
cord-022353-q2k2krnm	780	27	and	and	CC
cord-022353-q2k2krnm	780	28	DAG	DAG	NNP
cord-022353-q2k2krnm	780	29	.	.	.
cord-022353-q2k2krnm	781	1	When	when	WRB
cord-022353-q2k2krnm	781	2	combined	combine	VBN
cord-022353-q2k2krnm	781	3	with	with	IN
cord-022353-q2k2krnm	781	4	other	other	JJ
cord-022353-q2k2krnm	781	5	cytokines	cytokine	NNS
cord-022353-q2k2krnm	781	6	,	,	,
cord-022353-q2k2krnm	781	7	ligation	ligation	NN
cord-022353-q2k2krnm	781	8	of	of	IN
cord-022353-q2k2krnm	781	9	B	b	NN
cord-022353-q2k2krnm	781	10	-	-	HYPH
cord-022353-q2k2krnm	781	11	cell	cell	NN
cord-022353-q2k2krnm	782	1	CD40	CD40	NNP
cord-022353-q2k2krnm	782	2	provides	provide	VBZ
cord-022353-q2k2krnm	782	3	the	the	DT
cord-022353-q2k2krnm	782	4	second	second	JJ
cord-022353-q2k2krnm	782	5	signal	signal	NN
cord-022353-q2k2krnm	782	6	allowing	allow	VBG
cord-022353-q2k2krnm	782	7	differentiation	differentiation	NN
cord-022353-q2k2krnm	782	8	of	of	IN
cord-022353-q2k2krnm	782	9	B	b	NN
cord-022353-q2k2krnm	782	10	cells	cell	NNS
cord-022353-q2k2krnm	782	11	to	to	IN
cord-022353-q2k2krnm	782	12	plasma	plasma	NN
cord-022353-q2k2krnm	782	13	cells	cell	NNS
cord-022353-q2k2krnm	783	1	(	(	-LRB-
cord-022353-q2k2krnm	783	2	Goldsby	Goldsby	NNP
cord-022353-q2k2krnm	783	3	et	et	NNP
cord-022353-q2k2krnm	783	4	al	al	NNP
cord-022353-q2k2krnm	783	5	.	.	NNP
cord-022353-q2k2krnm	783	6	2003	2003	CD
cord-022353-q2k2krnm	783	7	)	)	-RRB-
cord-022353-q2k2krnm	783	8	.	.	.
cord-022353-q2k2krnm	784	1	iv	iv	LS
cord-022353-q2k2krnm	784	2	.	.	.
cord-022353-q2k2krnm	785	1	CD30L	CD30L	NNP
cord-022353-q2k2krnm	785	2	CD30L	CD30L	NNP
cord-022353-q2k2krnm	786	1	(	(	-LRB-
cord-022353-q2k2krnm	786	2	TNF5F8	tnf5f8	CC
cord-022353-q2k2krnm	786	3	,	,	,
cord-022353-q2k2krnm	786	4	CD153	cd153	NN
cord-022353-q2k2krnm	786	5	)	)	-RRB-
cord-022353-q2k2krnm	786	6	is	be	VBZ
cord-022353-q2k2krnm	786	7	a	a	DT
cord-022353-q2k2krnm	786	8	40-kDa	40-kda	CD
cord-022353-q2k2krnm	786	9	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	786	10	with	with	IN
cord-022353-q2k2krnm	786	11	72	72	CD
cord-022353-q2k2krnm	786	12	%	%	NN
cord-022353-q2k2krnm	786	13	sequence	sequence	NN
cord-022353-q2k2krnm	786	14	homology	homology	NN
cord-022353-q2k2krnm	786	15	between	between	IN
cord-022353-q2k2krnm	786	16	murine	murine	JJ
cord-022353-q2k2krnm	786	17	and	and	CC
cord-022353-q2k2krnm	786	18	human	human	JJ
cord-022353-q2k2krnm	786	19	molecules	molecule	NNS
cord-022353-q2k2krnm	786	20	.	.	.
cord-022353-q2k2krnm	787	1	CD30L	CD30L	NNP
cord-022353-q2k2krnm	787	2	is	be	VBZ
cord-022353-q2k2krnm	787	3	expressed	express	VBN
cord-022353-q2k2krnm	787	4	on	on	IN
cord-022353-q2k2krnm	787	5	monocytes	monocyte	NNS
cord-022353-q2k2krnm	787	6	,	,	,
cord-022353-q2k2krnm	787	7	macrophages	macrophage	NNS
cord-022353-q2k2krnm	787	8	,	,	,
cord-022353-q2k2krnm	787	9	B	b	NN
cord-022353-q2k2krnm	787	10	cells	cell	NNS
cord-022353-q2k2krnm	787	11	,	,	,
cord-022353-q2k2krnm	787	12	activated	activate	VBD
cord-022353-q2k2krnm	787	13	T	t	NN
cord-022353-q2k2krnm	787	14	cells	cell	NNS
cord-022353-q2k2krnm	787	15	,	,	,
cord-022353-q2k2krnm	787	16	neutrophils	neutrophil	NNS
cord-022353-q2k2krnm	787	17	,	,	,
cord-022353-q2k2krnm	787	18	megakaryocytes	megakaryocytes	NNP
cord-022353-q2k2krnm	787	19	,	,	,
cord-022353-q2k2krnm	787	20	resting	rest	VBG
cord-022353-q2k2krnm	787	21	CD2	CD2	NNP
cord-022353-q2k2krnm	787	22	§	§	:
cord-022353-q2k2krnm	787	23	T	T	NNP
cord-022353-q2k2krnm	787	24	cells	cell	NNS
cord-022353-q2k2krnm	787	25	,	,	,
cord-022353-q2k2krnm	787	26	erythroid	erythroid	JJ
cord-022353-q2k2krnm	787	27	precursors	precursor	NNS
cord-022353-q2k2krnm	787	28	,	,	,
cord-022353-q2k2krnm	787	29	and	and	CC
cord-022353-q2k2krnm	787	30	eosinophils	eosinophil	NNS
cord-022353-q2k2krnm	787	31	.	.	.
cord-022353-q2k2krnm	788	1	Ligation	ligation	NN
cord-022353-q2k2krnm	788	2	to	to	IN
cord-022353-q2k2krnm	788	3	CD30	CD30	NNP
cord-022353-q2k2krnm	788	4	can	can	MD
cord-022353-q2k2krnm	788	5	induce	induce	VB
cord-022353-q2k2krnm	788	6	either	either	CC
cord-022353-q2k2krnm	788	7	proliferation	proliferation	NN
cord-022353-q2k2krnm	788	8	or	or	CC
cord-022353-q2k2krnm	788	9	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	788	10	.	.	.
cord-022353-q2k2krnm	789	1	v.	v.	CC
cord-022353-q2k2krnm	789	2	FAS	FAS	NNP
cord-022353-q2k2krnm	789	3	LIGAND	LIGAND	NNP
cord-022353-q2k2krnm	790	1	(	(	-LRB-
cord-022353-q2k2krnm	790	2	FASL	FASL	NNP
cord-022353-q2k2krnm	790	3	)	)	-RRB-
cord-022353-q2k2krnm	790	4	FasL	FasL	NNP
cord-022353-q2k2krnm	790	5	(	(	-LRB-
cord-022353-q2k2krnm	790	6	also	also	RB
cord-022353-q2k2krnm	790	7	known	know	VBN
cord-022353-q2k2krnm	790	8	as	as	IN
cord-022353-q2k2krnm	790	9	TNFSF6	TNFSF6	NNP
cord-022353-q2k2krnm	790	10	)	)	-RRB-
cord-022353-q2k2krnm	790	11	,	,	,
cord-022353-q2k2krnm	790	12	is	be	VBZ
cord-022353-q2k2krnm	790	13	a	a	DT
cord-022353-q2k2krnm	790	14	40-kDa	40-kda	CD
cord-022353-q2k2krnm	790	15	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	790	16	that	that	IN
cord-022353-q2k2krnm	790	17	,	,	,
cord-022353-q2k2krnm	790	18	after	after	IN
cord-022353-q2k2krnm	790	19	cleavage	cleavage	NN
cord-022353-q2k2krnm	790	20	,	,	,
cord-022353-q2k2krnm	790	21	forms	form	VBZ
cord-022353-q2k2krnm	790	22	a	a	DT
cord-022353-q2k2krnm	790	23	70-kDa	70-kda	CD
cord-022353-q2k2krnm	790	24	homotrimer	homotrimer	NN
cord-022353-q2k2krnm	790	25	that	that	WDT
cord-022353-q2k2krnm	790	26	is	be	VBZ
cord-022353-q2k2krnm	790	27	active	active	JJ
cord-022353-q2k2krnm	790	28	only	only	RB
cord-022353-q2k2krnm	790	29	in	in	IN
cord-022353-q2k2krnm	790	30	membrane	membrane	NN
cord-022353-q2k2krnm	790	31	form	form	NN
cord-022353-q2k2krnm	790	32	in	in	IN
cord-022353-q2k2krnm	790	33	the	the	DT
cord-022353-q2k2krnm	790	34	mouse	mouse	NN
cord-022353-q2k2krnm	790	35	.	.	.
cord-022353-q2k2krnm	791	1	Polymorphisms	Polymorphisms	NNP
cord-022353-q2k2krnm	791	2	in	in	IN
cord-022353-q2k2krnm	791	3	FasL	FasL	NNP
cord-022353-q2k2krnm	791	4	also	also	RB
cord-022353-q2k2krnm	791	5	exist	exist	VBP
cord-022353-q2k2krnm	791	6	and	and	CC
cord-022353-q2k2krnm	791	7	a	a	DT
cord-022353-q2k2krnm	791	8	single	single	JJ
cord-022353-q2k2krnm	791	9	amino	amino	NN
cord-022353-q2k2krnm	791	10	acid	acid	NN
cord-022353-q2k2krnm	791	11	substitution	substitution	NN
cord-022353-q2k2krnm	791	12	in	in	IN
cord-022353-q2k2krnm	791	13	position	position	NN
cord-022353-q2k2krnm	791	14	273	273	CD
cord-022353-q2k2krnm	791	15	(	(	-LRB-
cord-022353-q2k2krnm	791	16	Phe	Phe	NNP
cord-022353-q2k2krnm	791	17	to	to	IN
cord-022353-q2k2krnm	791	18	Leu	Leu	NNP
cord-022353-q2k2krnm	791	19	)	)	-RRB-
cord-022353-q2k2krnm	791	20	results	result	VBZ
cord-022353-q2k2krnm	791	21	in	in	IN
cord-022353-q2k2krnm	791	22	the	the	DT
cord-022353-q2k2krnm	791	23	generalized	generalized	JJ
cord-022353-q2k2krnm	791	24	lymphoproliferative	lymphoproliferative	JJ
cord-022353-q2k2krnm	791	25	disease	disease	NN
cord-022353-q2k2krnm	791	26	(	(	-LRB-
cord-022353-q2k2krnm	791	27	gld	gld	NNP
cord-022353-q2k2krnm	791	28	)	)	-RRB-
cord-022353-q2k2krnm	791	29	mutation	mutation	NN
cord-022353-q2k2krnm	791	30	.	.	.
cord-022353-q2k2krnm	792	1	FasL	FasL	NNP
cord-022353-q2k2krnm	792	2	is	be	VBZ
cord-022353-q2k2krnm	792	3	expressed	express	VBN
cord-022353-q2k2krnm	792	4	on	on	IN
cord-022353-q2k2krnm	792	5	cells	cell	NNS
cord-022353-q2k2krnm	792	6	of	of	IN
cord-022353-q2k2krnm	792	7	the	the	DT
cord-022353-q2k2krnm	792	8	adaptive	adaptive	JJ
cord-022353-q2k2krnm	792	9	and	and	CC
cord-022353-q2k2krnm	792	10	innate	innate	JJ
cord-022353-q2k2krnm	792	11	immune	immune	JJ
cord-022353-q2k2krnm	792	12	systems	system	NNS
cord-022353-q2k2krnm	792	13	,	,	,
cord-022353-q2k2krnm	792	14	as	as	RB
cord-022353-q2k2krnm	792	15	well	well	RB
cord-022353-q2k2krnm	792	16	as	as	IN
cord-022353-q2k2krnm	792	17	cells	cell	NNS
cord-022353-q2k2krnm	792	18	of	of	IN
cord-022353-q2k2krnm	792	19	the	the	DT
cord-022353-q2k2krnm	792	20	lung	lung	NN
cord-022353-q2k2krnm	792	21	and	and	CC
cord-022353-q2k2krnm	792	22	intestine	intestine	NN
cord-022353-q2k2krnm	792	23	.	.	.
cord-022353-q2k2krnm	793	1	There	there	EX
cord-022353-q2k2krnm	793	2	is	be	VBZ
cord-022353-q2k2krnm	793	3	77	77	CD
cord-022353-q2k2krnm	793	4	%	%	NN
cord-022353-q2k2krnm	793	5	sequence	sequence	NN
cord-022353-q2k2krnm	793	6	homology	homology	NN
cord-022353-q2k2krnm	793	7	between	between	IN
cord-022353-q2k2krnm	793	8	murine	murine	JJ
cord-022353-q2k2krnm	793	9	FasL	FasL	NNP
cord-022353-q2k2krnm	793	10	and	and	CC
cord-022353-q2k2krnm	793	11	human	human	NN
cord-022353-q2k2krnm	793	12	FasL	FasL	NNP
cord-022353-q2k2krnm	794	1	(	(	-LRB-
cord-022353-q2k2krnm	794	2	Lynch	Lynch	NNP
cord-022353-q2k2krnm	794	3	et	et	NNP
cord-022353-q2k2krnm	794	4	al	al	NNP
cord-022353-q2k2krnm	794	5	.	.	.
cord-022353-q2k2krnm	794	6	1994	1994	CD
cord-022353-q2k2krnm	794	7	)	)	-RRB-
cord-022353-q2k2krnm	794	8	.	.	.
cord-022353-q2k2krnm	795	1	Ligation	ligation	NN
cord-022353-q2k2krnm	795	2	of	of	IN
cord-022353-q2k2krnm	795	3	Fas	Fas	NNP
cord-022353-q2k2krnm	795	4	by	by	IN
cord-022353-q2k2krnm	795	5	FasL	FasL	NNP
cord-022353-q2k2krnm	795	6	on	on	IN
cord-022353-q2k2krnm	795	7	mature	mature	NNP
cord-022353-q2k2krnm	795	8	T	t	NN
cord-022353-q2k2krnm	795	9	cells	cell	NNS
cord-022353-q2k2krnm	795	10	leads	lead	VBZ
cord-022353-q2k2krnm	795	11	to	to	IN
cord-022353-q2k2krnm	795	12	activation	activation	NN
cord-022353-q2k2krnm	795	13	of	of	IN
cord-022353-q2k2krnm	795	14	the	the	DT
cord-022353-q2k2krnm	795	15	caspase	caspase	NN
cord-022353-q2k2krnm	795	16	cascade	cascade	NN
cord-022353-q2k2krnm	795	17	and	and	CC
cord-022353-q2k2krnm	795	18	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	795	19	.	.	.
cord-022353-q2k2krnm	796	1	This	this	DT
cord-022353-q2k2krnm	796	2	is	be	VBZ
cord-022353-q2k2krnm	796	3	a	a	DT
cord-022353-q2k2krnm	796	4	major	major	JJ
cord-022353-q2k2krnm	796	5	homeostatic	homeostatic	JJ
cord-022353-q2k2krnm	796	6	mechanism	mechanism	NN
cord-022353-q2k2krnm	796	7	regulating	regulate	VBG
cord-022353-q2k2krnm	796	8	the	the	DT
cord-022353-q2k2krnm	796	9	size	size	NN
cord-022353-q2k2krnm	796	10	of	of	IN
cord-022353-q2k2krnm	796	11	the	the	DT
cord-022353-q2k2krnm	796	12	T	t	NN
cord-022353-q2k2krnm	796	13	-	-	HYPH
cord-022353-q2k2krnm	796	14	cell	cell	NN
cord-022353-q2k2krnm	796	15	pool	pool	NN
cord-022353-q2k2krnm	796	16	and	and	CC
cord-022353-q2k2krnm	796	17	for	for	IN
cord-022353-q2k2krnm	796	18	eliminating	eliminate	VBG
cord-022353-q2k2krnm	796	19	T	t	NN
cord-022353-q2k2krnm	796	20	cells	cell	NNS
cord-022353-q2k2krnm	796	21	that	that	WDT
cord-022353-q2k2krnm	796	22	repeatedly	repeatedly	RB
cord-022353-q2k2krnm	796	23	encounter	encounter	VBP
cord-022353-q2k2krnm	796	24	self	self	NN
cord-022353-q2k2krnm	796	25	-	-	HYPH
cord-022353-q2k2krnm	796	26	antigens	antigen	NNS
cord-022353-q2k2krnm	796	27	(	(	-LRB-
cord-022353-q2k2krnm	796	28	Goldsby	Goldsby	NNP
cord-022353-q2k2krnm	796	29	et	et	NNP
cord-022353-q2k2krnm	796	30	al	al	NNP
cord-022353-q2k2krnm	796	31	.	.	NNP
cord-022353-q2k2krnm	796	32	2003	2003	CD
cord-022353-q2k2krnm	796	33	)	)	-RRB-
cord-022353-q2k2krnm	796	34	.	.	.
cord-022353-q2k2krnm	797	1	vi	vi	NNP
cord-022353-q2k2krnm	797	2	.	.	.
cord-022353-q2k2krnm	798	1	TNF	TNF	NNP
cord-022353-q2k2krnm	798	2	-	-	HYPH
cord-022353-q2k2krnm	798	3	RELATEO	RELATEO	NNP
cord-022353-q2k2krnm	798	4	ACTIVATION	activation	NN
cord-022353-q2k2krnm	798	5	-	-	HYPH
cord-022353-q2k2krnm	798	6	INDUCED	induced	NN
cord-022353-q2k2krnm	798	7	CYTOKINES	cytokines	NN
cord-022353-q2k2krnm	798	8	(	(	-LRB-
cord-022353-q2k2krnm	798	9	TRANCE	TRANCE	NNP
cord-022353-q2k2krnm	798	10	)	)	-RRB-
cord-022353-q2k2krnm	798	11	TRANCE	TRANCE	NNP
cord-022353-q2k2krnm	798	12	,	,	,
cord-022353-q2k2krnm	798	13	also	also	RB
cord-022353-q2k2krnm	798	14	called	call	VBN
cord-022353-q2k2krnm	798	15	RANK	RANK	NNP
cord-022353-q2k2krnm	798	16	ligand	ligand	NN
cord-022353-q2k2krnm	798	17	and	and	CC
cord-022353-q2k2krnm	798	18	osteoprotegerin	osteoprotegerin	NN
cord-022353-q2k2krnm	798	19	ligand	ligand	NN
cord-022353-q2k2krnm	798	20	(	(	-LRB-
cord-022353-q2k2krnm	798	21	OPGL	OPGL	NNP
cord-022353-q2k2krnm	798	22	)	)	-RRB-
cord-022353-q2k2krnm	798	23	,	,	,
cord-022353-q2k2krnm	798	24	is	be	VBZ
cord-022353-q2k2krnm	798	25	an	an	DT
cord-022353-q2k2krnm	798	26	osteoclast	osteoclast	JJ
cord-022353-q2k2krnm	798	27	differentiation	differentiation	NN
cord-022353-q2k2krnm	798	28	factor	factor	NN
cord-022353-q2k2krnm	798	29	.	.	.
cord-022353-q2k2krnm	799	1	Mouse	mouse	NN
cord-022353-q2k2krnm	799	2	and	and	CC
cord-022353-q2k2krnm	799	3	human	human	JJ
cord-022353-q2k2krnm	799	4	share	share	NN
cord-022353-q2k2krnm	799	5	85	85	CD
cord-022353-q2k2krnm	799	6	%	%	NN
cord-022353-q2k2krnm	799	7	sequence	sequence	NN
cord-022353-q2k2krnm	799	8	homology	homology	NN
cord-022353-q2k2krnm	799	9	,	,	,
cord-022353-q2k2krnm	799	10	and	and	CC
cord-022353-q2k2krnm	799	11	TRANCE	TRANCE	NNP
cord-022353-q2k2krnm	799	12	is	be	VBZ
cord-022353-q2k2krnm	799	13	expressed	express	VBN
cord-022353-q2k2krnm	799	14	on	on	IN
cord-022353-q2k2krnm	799	15	T	T	NNP
cord-022353-q2k2krnm	799	16	cells	cell	NNS
cord-022353-q2k2krnm	799	17	and	and	CC
cord-022353-q2k2krnm	799	18	T	t	NN
cord-022353-q2k2krnm	799	19	-	-	HYPH
cord-022353-q2k2krnm	799	20	cell	cell	NN
cord-022353-q2k2krnm	799	21	rich	rich	JJ
cord-022353-q2k2krnm	799	22	organs	organ	NNS
cord-022353-q2k2krnm	799	23	such	such	JJ
cord-022353-q2k2krnm	799	24	as	as	IN
cord-022353-q2k2krnm	799	25	thymus	thymus	NN
cord-022353-q2k2krnm	799	26	and	and	CC
cord-022353-q2k2krnm	799	27	lymph	lymph	NN
cord-022353-q2k2krnm	799	28	nodes	node	NNS
cord-022353-q2k2krnm	799	29	.	.	.
cord-022353-q2k2krnm	800	1	vii	vii	NNP
cord-022353-q2k2krnm	800	2	.	.	.
cord-022353-q2k2krnm	801	1	TNF	TNF	NNP
cord-022353-q2k2krnm	801	2	-	-	HYPH
cord-022353-q2k2krnm	801	3	RECEerOR	RECEerOR	NNP
cord-022353-q2k2krnm	801	4	SUPERFAMILY	SUPERFAMILY	NNP
cord-022353-q2k2krnm	802	1	(	(	-LRB-
cord-022353-q2k2krnm	802	2	TNFRSF	TNFRSF	NNP
cord-022353-q2k2krnm	802	3	)	)	-RRB-
cord-022353-q2k2krnm	803	1	TNFRSF	TNFRSF	NNP
cord-022353-q2k2krnm	803	2	members	member	NNS
cord-022353-q2k2krnm	803	3	mediate	mediate	VBP
cord-022353-q2k2krnm	803	4	the	the	DT
cord-022353-q2k2krnm	803	5	cellular	cellular	JJ
cord-022353-q2k2krnm	803	6	effects	effect	NNS
cord-022353-q2k2krnm	803	7	of	of	IN
cord-022353-q2k2krnm	803	8	TNFSF	TNFSF	NNP
cord-022353-q2k2krnm	803	9	members	member	NNS
cord-022353-q2k2krnm	803	10	.	.	.
cord-022353-q2k2krnm	804	1	TNFRI	TNFRI	NNP
cord-022353-q2k2krnm	804	2	and	and	CC
cord-022353-q2k2krnm	804	3	TNFRII	TNFRII	NNP
cord-022353-q2k2krnm	804	4	bind	bind	VBP
cord-022353-q2k2krnm	804	5	TNF-~	TNF-~	NNP
cord-022353-q2k2krnm	804	6	and	and	CC
cord-022353-q2k2krnm	804	7	it	-PRON-	PRP
cord-022353-q2k2krnm	804	8	appears	appear	VBZ
cord-022353-q2k2krnm	804	9	TNF-~	TNF-~	NNP
cord-022353-q2k2krnm	804	10	complexes	complex	NNS
cord-022353-q2k2krnm	804	11	with	with	IN
cord-022353-q2k2krnm	804	12	LT-[3	lt-[3	RB
cord-022353-q2k2krnm	804	13	and	and	CC
cord-022353-q2k2krnm	804	14	the	the	DT
cord-022353-q2k2krnm	804	15	complex	complex	NN
cord-022353-q2k2krnm	804	16	binds	bind	VBZ
cord-022353-q2k2krnm	804	17	to	to	IN
cord-022353-q2k2krnm	804	18	TNFRI	TNFRI	NNP
cord-022353-q2k2krnm	804	19	or	or	CC
cord-022353-q2k2krnm	804	20	LT-[~	lt-[~	IN
cord-022353-q2k2krnm	804	21	receptor	receptor	NN
cord-022353-q2k2krnm	804	22	.	.	.
cord-022353-q2k2krnm	805	1	CD40	CD40	NNP
cord-022353-q2k2krnm	805	2	is	be	VBZ
cord-022353-q2k2krnm	805	3	associated	associate	VBN
cord-022353-q2k2krnm	805	4	with	with	IN
cord-022353-q2k2krnm	805	5	B	b	NN
cord-022353-q2k2krnm	805	6	-	-	HYPH
cord-022353-q2k2krnm	805	7	cell	cell	NN
cord-022353-q2k2krnm	805	8	proliferation	proliferation	NN
cord-022353-q2k2krnm	805	9	but	but	CC
cord-022353-q2k2krnm	805	10	is	be	VBZ
cord-022353-q2k2krnm	805	11	expressed	express	VBN
cord-022353-q2k2krnm	805	12	on	on	IN
cord-022353-q2k2krnm	805	13	many	many	JJ
cord-022353-q2k2krnm	805	14	cells	cell	NNS
cord-022353-q2k2krnm	805	15	throughout	throughout	IN
cord-022353-q2k2krnm	805	16	the	the	DT
cord-022353-q2k2krnm	805	17	body	body	NN
cord-022353-q2k2krnm	805	18	.	.	.
cord-022353-q2k2krnm	806	1	Mouse	Mouse	NNP
cord-022353-q2k2krnm	806	2	CD40	CD40	NNP
cord-022353-q2k2krnm	806	3	shares	share	VBZ
cord-022353-q2k2krnm	806	4	62	62	CD
cord-022353-q2k2krnm	806	5	%	%	NN
cord-022353-q2k2krnm	806	6	sequence	sequence	NN
cord-022353-q2k2krnm	806	7	homology	homology	NN
cord-022353-q2k2krnm	806	8	with	with	IN
cord-022353-q2k2krnm	806	9	human	human	JJ
cord-022353-q2k2krnm	806	10	CD40	CD40	NNP
cord-022353-q2k2krnm	806	11	;	;	:
cord-022353-q2k2krnm	806	12	however	however	RB
cord-022353-q2k2krnm	806	13	,	,	,
cord-022353-q2k2krnm	806	14	the	the	DT
cord-022353-q2k2krnm	806	15	mouse	mouse	NN
cord-022353-q2k2krnm	806	16	molecule	molecule	NN
cord-022353-q2k2krnm	806	17	has	have	VBZ
cord-022353-q2k2krnm	806	18	a	a	DT
cord-022353-q2k2krnm	806	19	28	28	CD
cord-022353-q2k2krnm	806	20	amino	amino	NN
cord-022353-q2k2krnm	806	21	acid	acid	NN
cord-022353-q2k2krnm	806	22	extension	extension	NN
cord-022353-q2k2krnm	806	23	of	of	IN
cord-022353-q2k2krnm	806	24	its	-PRON-	PRP$
cord-022353-q2k2krnm	806	25	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	806	26	tail	tail	NN
cord-022353-q2k2krnm	806	27	.	.	.
cord-022353-q2k2krnm	807	1	CD30	CD30	NNP
cord-022353-q2k2krnm	807	2	has	have	VBZ
cord-022353-q2k2krnm	807	3	480	480	CD
cord-022353-q2k2krnm	807	4	amino	amino	NN
cord-022353-q2k2krnm	807	5	acid	acid	NN
cord-022353-q2k2krnm	807	6	residues	residue	NNS
cord-022353-q2k2krnm	807	7	and	and	CC
cord-022353-q2k2krnm	807	8	a	a	DT
cord-022353-q2k2krnm	807	9	90	90	CD
cord-022353-q2k2krnm	807	10	amino	amino	NN
cord-022353-q2k2krnm	807	11	acid	acid	NN
cord-022353-q2k2krnm	807	12	deletion	deletion	NN
cord-022353-q2k2krnm	807	13	in	in	IN
cord-022353-q2k2krnm	807	14	the	the	DT
cord-022353-q2k2krnm	807	15	extracellular	extracellular	JJ
cord-022353-q2k2krnm	807	16	region	region	NN
cord-022353-q2k2krnm	807	17	compared	compare	VBN
cord-022353-q2k2krnm	807	18	to	to	IN
cord-022353-q2k2krnm	807	19	human	human	NN
cord-022353-q2k2krnm	807	20	.	.	.
cord-022353-q2k2krnm	808	1	It	-PRON-	PRP
cord-022353-q2k2krnm	808	2	is	be	VBZ
cord-022353-q2k2krnm	808	3	expressed	express	VBN
cord-022353-q2k2krnm	808	4	on	on	IN
cord-022353-q2k2krnm	808	5	CD4	CD4	NNP
cord-022353-q2k2krnm	808	6	+	+	CC
cord-022353-q2k2krnm	808	7	and	and	CC
cord-022353-q2k2krnm	808	8	CD5	CD5	NNP
cord-022353-q2k2krnm	808	9	+	+	CC
cord-022353-q2k2krnm	808	10	T	t	NN
cord-022353-q2k2krnm	808	11	cells	cell	NNS
cord-022353-q2k2krnm	808	12	and	and	CC
cord-022353-q2k2krnm	808	13	ligation	ligation	NN
cord-022353-q2k2krnm	808	14	results	result	NNS
cord-022353-q2k2krnm	808	15	in	in	IN
cord-022353-q2k2krnm	808	16	production	production	NN
cord-022353-q2k2krnm	808	17	of	of	IN
cord-022353-q2k2krnm	808	18	IL-5	IL-5	NNP
cord-022353-q2k2krnm	808	19	.	.	.
cord-022353-q2k2krnm	809	1	Murine	murine	JJ
cord-022353-q2k2krnm	809	2	Fas	Fas	NNP
cord-022353-q2k2krnm	809	3	lacks	lack	VBZ
cord-022353-q2k2krnm	809	4	8	8	CD
cord-022353-q2k2krnm	809	5	amino	amino	NN
cord-022353-q2k2krnm	809	6	acid	acid	NN
cord-022353-q2k2krnm	809	7	residues	residue	NNS
cord-022353-q2k2krnm	809	8	found	find	VBN
cord-022353-q2k2krnm	809	9	in	in	IN
cord-022353-q2k2krnm	809	10	human	human	NN
cord-022353-q2k2krnm	809	11	and	and	CC
cord-022353-q2k2krnm	809	12	shares	share	NNS
cord-022353-q2k2krnm	809	13	only	only	RB
cord-022353-q2k2krnm	809	14	50	50	CD
cord-022353-q2k2krnm	809	15	%	%	NN
cord-022353-q2k2krnm	809	16	sequence	sequence	NN
cord-022353-q2k2krnm	809	17	homology	homology	NN
cord-022353-q2k2krnm	809	18	.	.	.
cord-022353-q2k2krnm	810	1	Soluble	soluble	JJ
cord-022353-q2k2krnm	810	2	forms	form	NNS
cord-022353-q2k2krnm	810	3	result	result	VBP
cord-022353-q2k2krnm	810	4	from	from	IN
cord-022353-q2k2krnm	810	5	alternative	alternative	JJ
cord-022353-q2k2krnm	810	6	gene	gene	NN
cord-022353-q2k2krnm	810	7	splicing	splicing	NN
cord-022353-q2k2krnm	810	8	and	and	CC
cord-022353-q2k2krnm	810	9	circulate	circulate	VB
cord-022353-q2k2krnm	810	10	as	as	IN
cord-022353-q2k2krnm	810	11	dimers	dimer	NNS
cord-022353-q2k2krnm	810	12	or	or	CC
cord-022353-q2k2krnm	810	13	trimers	trimer	NNS
cord-022353-q2k2krnm	810	14	.	.	.
cord-022353-q2k2krnm	811	1	Fas	Fas	NNP
cord-022353-q2k2krnm	811	2	is	be	VBZ
cord-022353-q2k2krnm	811	3	expressed	express	VBN
cord-022353-q2k2krnm	811	4	by	by	IN
cord-022353-q2k2krnm	811	5	CD34	CD34	NNP
cord-022353-q2k2krnm	811	6	stem	stem	NN
cord-022353-q2k2krnm	811	7	cells	cell	NNS
cord-022353-q2k2krnm	811	8	,	,	,
cord-022353-q2k2krnm	811	9	fibroblasts	fibroblast	NNS
cord-022353-q2k2krnm	811	10	,	,	,
cord-022353-q2k2krnm	811	11	NK	NK	NNP
cord-022353-q2k2krnm	811	12	cells	cell	NNS
cord-022353-q2k2krnm	811	13	,	,	,
cord-022353-q2k2krnm	811	14	keratinocytes	keratinocyte	NNS
cord-022353-q2k2krnm	811	15	,	,	,
cord-022353-q2k2krnm	811	16	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	811	17	,	,	,
cord-022353-q2k2krnm	811	18	B	b	NN
cord-022353-q2k2krnm	811	19	and	and	CC
cord-022353-q2k2krnm	811	20	T	t	NN
cord-022353-q2k2krnm	811	21	cells	cell	NNS
cord-022353-q2k2krnm	811	22	(	(	-LRB-
cord-022353-q2k2krnm	811	23	and	and	CC
cord-022353-q2k2krnm	811	24	their	-PRON-	PRP$
cord-022353-q2k2krnm	811	25	precursors	precursor	NNS
cord-022353-q2k2krnm	811	26	)	)	-RRB-
cord-022353-q2k2krnm	811	27	,	,	,
cord-022353-q2k2krnm	811	28	and	and	CC
cord-022353-q2k2krnm	811	29	eosinophils	eosinophil	NNS
cord-022353-q2k2krnm	811	30	.	.	.
cord-022353-q2k2krnm	812	1	Osteoprotegerin	Osteoprotegerin	NNP
cord-022353-q2k2krnm	812	2	(	(	-LRB-
cord-022353-q2k2krnm	812	3	OPG	OPG	NNP
cord-022353-q2k2krnm	812	4	)	)	-RRB-
cord-022353-q2k2krnm	812	5	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	812	6	the	the	DT
cord-022353-q2k2krnm	812	7	action	action	NN
cord-022353-q2k2krnm	812	8	of	of	IN
cord-022353-q2k2krnm	812	9	osteoclasts	osteoclast	NNS
cord-022353-q2k2krnm	812	10	and	and	CC
cord-022353-q2k2krnm	812	11	is	be	VBZ
cord-022353-q2k2krnm	812	12	a	a	DT
cord-022353-q2k2krnm	812	13	secreted	secrete	VBN
cord-022353-q2k2krnm	812	14	member	member	NN
cord-022353-q2k2krnm	812	15	of	of	IN
cord-022353-q2k2krnm	812	16	the	the	DT
cord-022353-q2k2krnm	812	17	TNFRSE	TNFRSE	NNP
cord-022353-q2k2krnm	812	18	although	although	IN
cord-022353-q2k2krnm	812	19	it	-PRON-	PRP
cord-022353-q2k2krnm	812	20	has	have	VBZ
cord-022353-q2k2krnm	812	21	no	no	DT
cord-022353-q2k2krnm	812	22	transmembrane	transmembrane	NN
cord-022353-q2k2krnm	812	23	segment	segment	NN
cord-022353-q2k2krnm	812	24	and	and	CC
cord-022353-q2k2krnm	812	25	circulates	circulate	VBZ
cord-022353-q2k2krnm	812	26	as	as	IN
cord-022353-q2k2krnm	812	27	a	a	DT
cord-022353-q2k2krnm	812	28	disulfide	disulfide	RB
cord-022353-q2k2krnm	812	29	-	-	HYPH
cord-022353-q2k2krnm	812	30	linked	link	VBN
cord-022353-q2k2krnm	812	31	homodimer	homodimer	RB
cord-022353-q2k2krnm	812	32	.	.	.
cord-022353-q2k2krnm	813	1	Murine	Murine	NNP
cord-022353-q2k2krnm	813	2	TROY	TROY	NNP
cord-022353-q2k2krnm	813	3	,	,	,
cord-022353-q2k2krnm	813	4	also	also	RB
cord-022353-q2k2krnm	813	5	named	name	VBD
cord-022353-q2k2krnm	813	6	toxicity	toxicity	NN
cord-022353-q2k2krnm	813	7	and	and	CC
cord-022353-q2k2krnm	813	8	JNK	JNK	NNP
cord-022353-q2k2krnm	813	9	inducer	inducer	NN
cord-022353-q2k2krnm	813	10	(	(	-LRB-
cord-022353-q2k2krnm	813	11	TAJ	TAJ	NNP
cord-022353-q2k2krnm	813	12	)	)	-RRB-
cord-022353-q2k2krnm	813	13	and	and	CC
cord-022353-q2k2krnm	813	14	TNFRSF19	TNFRSF19	NNP
cord-022353-q2k2krnm	813	15	,	,	,
cord-022353-q2k2krnm	813	16	shares	share	VBZ
cord-022353-q2k2krnm	813	17	92	92	CD
cord-022353-q2k2krnm	813	18	%	%	NN
cord-022353-q2k2krnm	813	19	homology	homology	NN
cord-022353-q2k2krnm	813	20	with	with	IN
cord-022353-q2k2krnm	813	21	human	human	NN
cord-022353-q2k2krnm	813	22	in	in	IN
cord-022353-q2k2krnm	813	23	its	-PRON-	PRP$
cord-022353-q2k2krnm	813	24	extracellular	extracellular	JJ
cord-022353-q2k2krnm	813	25	domains	domain	NNS
cord-022353-q2k2krnm	813	26	.	.	.
cord-022353-q2k2krnm	814	1	d.	d.	NNP
cord-022353-q2k2krnm	814	2	INTERFERONS	INTERFERONS	NNP
cord-022353-q2k2krnm	814	3	Interferons	Interferons	NNPS
cord-022353-q2k2krnm	814	4	are	be	VBP
cord-022353-q2k2krnm	814	5	a	a	DT
cord-022353-q2k2krnm	814	6	group	group	NN
cord-022353-q2k2krnm	814	7	of	of	IN
cord-022353-q2k2krnm	814	8	related	relate	VBN
cord-022353-q2k2krnm	814	9	but	but	CC
cord-022353-q2k2krnm	814	10	distinct	distinct	JJ
cord-022353-q2k2krnm	814	11	proteins	protein	NNS
cord-022353-q2k2krnm	814	12	that	that	WDT
cord-022353-q2k2krnm	814	13	share	share	VBP
cord-022353-q2k2krnm	814	14	more	more	JJR
cord-022353-q2k2krnm	814	15	than	than	IN
cord-022353-q2k2krnm	814	16	95	95	CD
cord-022353-q2k2krnm	814	17	%	%	NN
cord-022353-q2k2krnm	814	18	amino	amino	NN
cord-022353-q2k2krnm	814	19	acid	acid	NN
cord-022353-q2k2krnm	814	20	sequence	sequence	NN
cord-022353-q2k2krnm	814	21	homology	homology	NN
cord-022353-q2k2krnm	814	22	.	.	.
cord-022353-q2k2krnm	815	1	Members	member	NNS
cord-022353-q2k2krnm	815	2	of	of	IN
cord-022353-q2k2krnm	815	3	the	the	DT
cord-022353-q2k2krnm	815	4	type	type	NN
cord-022353-q2k2krnm	815	5	I	-PRON-	PRP
cord-022353-q2k2krnm	815	6	interferon	interferon	VBD
cord-022353-q2k2krnm	815	7	family	family	NN
cord-022353-q2k2krnm	815	8	share	share	VBP
cord-022353-q2k2krnm	815	9	a	a	DT
cord-022353-q2k2krnm	815	10	common	common	JJ
cord-022353-q2k2krnm	815	11	cell	cell	NN
cord-022353-q2k2krnm	815	12	surface	surface	NN
cord-022353-q2k2krnm	815	13	receptor	receptor	NN
cord-022353-q2k2krnm	815	14	composed	compose	VBN
cord-022353-q2k2krnm	815	15	of	of	IN
cord-022353-q2k2krnm	815	16	two	two	CD
cord-022353-q2k2krnm	815	17	subunits	subunit	NNS
cord-022353-q2k2krnm	815	18	.	.	.
cord-022353-q2k2krnm	816	1	Commercially	commercially	RB
cord-022353-q2k2krnm	816	2	available	available	JJ
cord-022353-q2k2krnm	816	3	ELISA	ELISA	NNP
cord-022353-q2k2krnm	816	4	kits	kit	NNS
cord-022353-q2k2krnm	816	5	may	may	MD
cord-022353-q2k2krnm	816	6	be	be	VB
cord-022353-q2k2krnm	816	7	used	use	VBN
cord-022353-q2k2krnm	816	8	to	to	TO
cord-022353-q2k2krnm	816	9	quantify	quantify	VB
cord-022353-q2k2krnm	817	1	murine	murine	JJ
cord-022353-q2k2krnm	817	2	io	io	FW
cord-022353-q2k2krnm	817	3	INTERFERON-~	INTERFERON-~	NNP
cord-022353-q2k2krnm	817	4	(	(	-LRB-
cord-022353-q2k2krnm	817	5	IFN-~	IFN-~	NNP
cord-022353-q2k2krnm	817	6	)	)	-RRB-
cord-022353-q2k2krnm	817	7	IFN-~	IFN-~	NNP
cord-022353-q2k2krnm	817	8	is	be	VBZ
cord-022353-q2k2krnm	817	9	induced	induce	VBN
cord-022353-q2k2krnm	817	10	in	in	IN
cord-022353-q2k2krnm	817	11	a	a	DT
cord-022353-q2k2krnm	817	12	wide	wide	JJ
cord-022353-q2k2krnm	817	13	variety	variety	NN
cord-022353-q2k2krnm	817	14	of	of	IN
cord-022353-q2k2krnm	817	15	cells	cell	NNS
cord-022353-q2k2krnm	817	16	,	,	,
cord-022353-q2k2krnm	817	17	including	include	VBG
cord-022353-q2k2krnm	817	18	monocytes	monocyte	NNS
cord-022353-q2k2krnm	817	19	and	and	CC
cord-022353-q2k2krnm	817	20	macrophages	macrophage	NNS
cord-022353-q2k2krnm	817	21	,	,	,
cord-022353-q2k2krnm	817	22	in	in	IN
cord-022353-q2k2krnm	817	23	response	response	NN
cord-022353-q2k2krnm	817	24	to	to	IN
cord-022353-q2k2krnm	817	25	viral	viral	JJ
cord-022353-q2k2krnm	817	26	infection	infection	NN
cord-022353-q2k2krnm	817	27	.	.	.
cord-022353-q2k2krnm	818	1	One	one	CD
cord-022353-q2k2krnm	818	2	known	know	VBN
cord-022353-q2k2krnm	818	3	inducer	inducer	NN
cord-022353-q2k2krnm	818	4	is	be	VBZ
cord-022353-q2k2krnm	818	5	double	double	RB
cord-022353-q2k2krnm	818	6	stranded	strand	VBN
cord-022353-q2k2krnm	818	7	ribonucleic	ribonucleic	NN
cord-022353-q2k2krnm	818	8	acid	acid	NN
cord-022353-q2k2krnm	818	9	(	(	-LRB-
cord-022353-q2k2krnm	818	10	dsRNA	dsrna	NN
cord-022353-q2k2krnm	818	11	)	)	-RRB-
cord-022353-q2k2krnm	818	12	.	.	.
cord-022353-q2k2krnm	819	1	induce	induce	VB
cord-022353-q2k2krnm	819	2	resistance	resistance	NN
cord-022353-q2k2krnm	819	3	to	to	IN
cord-022353-q2k2krnm	819	4	viral	viral	JJ
cord-022353-q2k2krnm	819	5	replication	replication	NN
cord-022353-q2k2krnm	819	6	by	by	IN
cord-022353-q2k2krnm	819	7	binding	bind	VBG
cord-022353-q2k2krnm	819	8	the	the	DT
cord-022353-q2k2krnm	819	9	IFN-~/~	ifn-~/~	PRP$
cord-022353-q2k2krnm	819	10	receptor	receptor	NN
cord-022353-q2k2krnm	819	11	,	,	,
cord-022353-q2k2krnm	819	12	which	which	WDT
cord-022353-q2k2krnm	819	13	activates	activate	VBZ
cord-022353-q2k2krnm	819	14	the	the	DT
cord-022353-q2k2krnm	819	15	JAK	JAK	NNP
cord-022353-q2k2krnm	819	16	-	-	HYPH
cord-022353-q2k2krnm	819	17	STAT	stat	NN
cord-022353-q2k2krnm	819	18	pathway	pathway	NN
cord-022353-q2k2krnm	819	19	,	,	,
cord-022353-q2k2krnm	819	20	inducing	induce	VBG
cord-022353-q2k2krnm	819	21	several	several	JJ
cord-022353-q2k2krnm	819	22	genes	gene	NNS
cord-022353-q2k2krnm	819	23	.	.	.
cord-022353-q2k2krnm	820	1	One	one	CD
cord-022353-q2k2krnm	820	2	of	of	IN
cord-022353-q2k2krnm	820	3	those	those	DT
cord-022353-q2k2krnm	820	4	genes	gene	NNS
cord-022353-q2k2krnm	820	5	is	be	VBZ
cord-022353-q2k2krnm	820	6	ribonuclease	ribonuclease	NN
cord-022353-q2k2krnm	820	7	,	,	,
cord-022353-q2k2krnm	820	8	which	which	WDT
cord-022353-q2k2krnm	820	9	degrades	degrade	VBZ
cord-022353-q2k2krnm	820	10	viral	viral	JJ
cord-022353-q2k2krnm	820	11	RNA	RNA	NNP
cord-022353-q2k2krnm	820	12	.	.	.
cord-022353-q2k2krnm	821	1	Binding	bind	VBG
cord-022353-q2k2krnm	821	2	of	of	IN
cord-022353-q2k2krnm	821	3	IFN-~	IFN-~	NNP
cord-022353-q2k2krnm	821	4	to	to	IN
cord-022353-q2k2krnm	821	5	NK	NK	NNP
cord-022353-q2k2krnm	821	6	cells	cell	NNS
cord-022353-q2k2krnm	821	7	enhances	enhance	VBZ
cord-022353-q2k2krnm	821	8	their	-PRON-	PRP$
cord-022353-q2k2krnm	821	9	lytic	lytic	JJ
cord-022353-q2k2krnm	821	10	activity	activity	NN
cord-022353-q2k2krnm	821	11	for	for	IN
cord-022353-q2k2krnm	821	12	virally	virally	RB
cord-022353-q2k2krnm	821	13	infected	infect	VBN
cord-022353-q2k2krnm	821	14	cells	cell	NNS
cord-022353-q2k2krnm	821	15	.	.	.
cord-022353-q2k2krnm	822	1	IFN-~	IFN-~	NNP
cord-022353-q2k2krnm	822	2	is	be	VBZ
cord-022353-q2k2krnm	822	3	secreted	secrete	VBN
cord-022353-q2k2krnm	822	4	by	by	IN
cord-022353-q2k2krnm	822	5	leukocytes	leukocyte	NNS
cord-022353-q2k2krnm	822	6	.	.	.
cord-022353-q2k2krnm	823	1	iii	iii	NNP
cord-022353-q2k2krnm	823	2	INrEtUrElCON-'t(IFN	INrEtUrElCON-'t(IFN	NNP
cord-022353-q2k2krnm	823	3	-	-	HYPH
cord-022353-q2k2krnm	823	4	y	y	NNP
cord-022353-q2k2krnm	823	5	)	)	-RRB-
cord-022353-q2k2krnm	824	1	IFN	IFN	NNP
cord-022353-q2k2krnm	824	2	-	-	HYPH
cord-022353-q2k2krnm	824	3	y	y	NNP
cord-022353-q2k2krnm	824	4	is	be	VBZ
cord-022353-q2k2krnm	824	5	secreted	secrete	VBN
cord-022353-q2k2krnm	824	6	by	by	IN
cord-022353-q2k2krnm	824	7	TH1	th1	NN
cord-022353-q2k2krnm	824	8	cells	cell	NNS
cord-022353-q2k2krnm	824	9	,	,	,
cord-022353-q2k2krnm	824	10	NK	NK	NNP
cord-022353-q2k2krnm	824	11	cells	cell	NNS
cord-022353-q2k2krnm	824	12	,	,	,
cord-022353-q2k2krnm	824	13	and	and	CC
cord-022353-q2k2krnm	824	14	cytotoxic	cytotoxic	JJ
cord-022353-q2k2krnm	824	15	T	t	NN
cord-022353-q2k2krnm	824	16	cells	cell	NNS
cord-022353-q2k2krnm	824	17	(	(	-LRB-
cord-022353-q2k2krnm	824	18	Tc	Tc	NNP
cord-022353-q2k2krnm	824	19	)	)	-RRB-
cord-022353-q2k2krnm	824	20	,	,	,
cord-022353-q2k2krnm	824	21	which	which	WDT
cord-022353-q2k2krnm	824	22	activates	activate	VBZ
cord-022353-q2k2krnm	824	23	macrophages	macrophage	NNS
cord-022353-q2k2krnm	824	24	to	to	TO
cord-022353-q2k2krnm	824	25	secrete	secrete	VB
cord-022353-q2k2krnm	824	26	TNF	TNF	NNP
cord-022353-q2k2krnm	824	27	-	-	HYPH
cord-022353-q2k2krnm	824	28	ct	ct	NNP
cord-022353-q2k2krnm	824	29	,	,	,
cord-022353-q2k2krnm	824	30	express	express	NNP
cord-022353-q2k2krnm	824	31	class	class	NNP
cord-022353-q2k2krnm	824	32	II	II	NNP
cord-022353-q2k2krnm	824	33	major	major	JJ
cord-022353-q2k2krnm	824	34	histocompatibility	histocompatibility	NN
cord-022353-q2k2krnm	824	35	complex	complex	NN
cord-022353-q2k2krnm	824	36	(	(	-LRB-
cord-022353-q2k2krnm	824	37	MHC	MHC	NNP
cord-022353-q2k2krnm	824	38	)	)	-RRB-
cord-022353-q2k2krnm	824	39	molecules	molecule	NNS
cord-022353-q2k2krnm	824	40	,	,	,
cord-022353-q2k2krnm	824	41	and	and	CC
cord-022353-q2k2krnm	824	42	produce	produce	VB
cord-022353-q2k2krnm	824	43	antimicrobial	antimicrobial	JJ
cord-022353-q2k2krnm	824	44	activities	activity	NNS
cord-022353-q2k2krnm	824	45	.	.	.
cord-022353-q2k2krnm	825	1	IFN	IFN	NNP
cord-022353-q2k2krnm	825	2	-	-	HYPH
cord-022353-q2k2krnm	825	3	y	y	NNP
cord-022353-q2k2krnm	825	4	secretion	secretion	NN
cord-022353-q2k2krnm	825	5	by	by	IN
cord-022353-q2k2krnm	825	6	TH1	TH1	NNP
cord-022353-q2k2krnm	825	7	also	also	RB
cord-022353-q2k2krnm	825	8	induces	induce	VBZ
cord-022353-q2k2krnm	825	9	antibody	antibody	NN
cord-022353-q2k2krnm	825	10	-	-	HYPH
cord-022353-q2k2krnm	825	11	class	class	NN
cord-022353-q2k2krnm	825	12	switch	switch	NN
cord-022353-q2k2krnm	825	13	to	to	IN
cord-022353-q2k2krnm	825	14	IgG2a	IgG2a	NNP
cord-022353-q2k2krnm	825	15	,	,	,
cord-022353-q2k2krnm	825	16	which	which	WDT
cord-022353-q2k2krnm	825	17	supports	support	VBZ
cord-022353-q2k2krnm	825	18	phagocytosis	phagocytosis	NN
cord-022353-q2k2krnm	825	19	and	and	CC
cord-022353-q2k2krnm	825	20	complement	complement	VB
cord-022353-q2k2krnm	825	21	fixation	fixation	NN
cord-022353-q2k2krnm	825	22	.	.	.
cord-022353-q2k2krnm	826	1	IFN	IFN	NNP
cord-022353-q2k2krnm	826	2	-	-	HYPH
cord-022353-q2k2krnm	826	3	y	y	NNP
cord-022353-q2k2krnm	826	4	promotes	promote	VBZ
cord-022353-q2k2krnm	826	5	differentiation	differentiation	NN
cord-022353-q2k2krnm	826	6	of	of	IN
cord-022353-q2k2krnm	826	7	Tc	Tc	NNP
cord-022353-q2k2krnm	826	8	from	from	IN
cord-022353-q2k2krnm	826	9	CD8	CD8	NNP
cord-022353-q2k2krnm	826	10	+	+	CC
cord-022353-q2k2krnm	826	11	precursors	precursor	NNS
cord-022353-q2k2krnm	826	12	that	that	WDT
cord-022353-q2k2krnm	826	13	will	will	MD
cord-022353-q2k2krnm	826	14	be	be	VB
cord-022353-q2k2krnm	826	15	involved	involve	VBN
cord-022353-q2k2krnm	826	16	in	in	IN
cord-022353-q2k2krnm	826	17	the	the	DT
cord-022353-q2k2krnm	826	18	effector	effector	JJ
cord-022353-q2k2krnm	826	19	response	response	NN
cord-022353-q2k2krnm	826	20	to	to	IN
cord-022353-q2k2krnm	826	21	viral	viral	JJ
cord-022353-q2k2krnm	826	22	infections	infection	NNS
cord-022353-q2k2krnm	826	23	and	and	CC
cord-022353-q2k2krnm	826	24	intracellular	intracellular	JJ
cord-022353-q2k2krnm	826	25	pathogens	pathogen	NNS
cord-022353-q2k2krnm	826	26	.	.	.
cord-022353-q2k2krnm	827	1	IFN	IFN	NNP
cord-022353-q2k2krnm	827	2	-	-	HYPH
cord-022353-q2k2krnm	827	3	y	y	NNP
cord-022353-q2k2krnm	827	4	also	also	RB
cord-022353-q2k2krnm	827	5	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	827	6	the	the	DT
cord-022353-q2k2krnm	827	7	expansion	expansion	NN
cord-022353-q2k2krnm	827	8	of	of	IN
cord-022353-q2k2krnm	827	9	TH2	TH2	NNP
cord-022353-q2k2krnm	827	10	cells	cell	NNS
cord-022353-q2k2krnm	827	11	.	.	.
cord-022353-q2k2krnm	828	1	IFN	IFN	NNP
cord-022353-q2k2krnm	828	2	-	-	HYPH
cord-022353-q2k2krnm	828	3	y	y	NNP
cord-022353-q2k2krnm	828	4	secretion	secretion	NN
cord-022353-q2k2krnm	828	5	is	be	VBZ
cord-022353-q2k2krnm	828	6	induced	induce	VBN
cord-022353-q2k2krnm	828	7	by	by	IN
cord-022353-q2k2krnm	828	8	successful	successful	JJ
cord-022353-q2k2krnm	828	9	stimulation	stimulation	NN
cord-022353-q2k2krnm	828	10	of	of	IN
cord-022353-q2k2krnm	828	11	T	t	NN
cord-022353-q2k2krnm	828	12	cells	cell	NNS
cord-022353-q2k2krnm	828	13	by	by	IN
cord-022353-q2k2krnm	828	14	antigen	antigen	NN
cord-022353-q2k2krnm	828	15	presenting	present	VBG
cord-022353-q2k2krnm	828	16	cells	cell	NNS
cord-022353-q2k2krnm	828	17	.	.	.
cord-022353-q2k2krnm	829	1	e.	e.	NNP
cord-022353-q2k2krnm	829	2	CHEMO	CHEMO	NNP
cord-022353-q2k2krnm	830	1	~S	~S	NNP
cord-022353-q2k2krnm	830	2	Chemokines	Chemokines	NNPS
cord-022353-q2k2krnm	830	3	,	,	,
cord-022353-q2k2krnm	830	4	along	along	IN
cord-022353-q2k2krnm	830	5	with	with	IN
cord-022353-q2k2krnm	830	6	adhesion	adhesion	NN
cord-022353-q2k2krnm	830	7	molecules	molecule	NNS
cord-022353-q2k2krnm	830	8	,	,	,
cord-022353-q2k2krnm	830	9	are	be	VBP
cord-022353-q2k2krnm	830	10	the	the	DT
cord-022353-q2k2krnm	830	11	principle	principle	JJ
cord-022353-q2k2krnm	830	12	controllers	controller	NNS
cord-022353-q2k2krnm	830	13	of	of	IN
cord-022353-q2k2krnm	830	14	leukocyte	leukocyte	NN
cord-022353-q2k2krnm	830	15	migration	migration	NN
cord-022353-q2k2krnm	830	16	and	and	CC
cord-022353-q2k2krnm	830	17	as	as	IN
cord-022353-q2k2krnm	830	18	such	such	JJ
cord-022353-q2k2krnm	830	19	directly	directly	RB
cord-022353-q2k2krnm	830	20	affect	affect	VBP
cord-022353-q2k2krnm	830	21	leukocyte	leukocyte	NN
cord-022353-q2k2krnm	830	22	retention	retention	NN
cord-022353-q2k2krnm	830	23	and	and	CC
cord-022353-q2k2krnm	830	24	relocation	relocation	NN
cord-022353-q2k2krnm	830	25	during	during	IN
cord-022353-q2k2krnm	830	26	hematopoiesis	hematopoiesis	NN
cord-022353-q2k2krnm	830	27	and	and	CC
cord-022353-q2k2krnm	830	28	at	at	IN
cord-022353-q2k2krnm	830	29	sites	site	NNS
cord-022353-q2k2krnm	830	30	of	of	IN
cord-022353-q2k2krnm	830	31	immune	immune	JJ
cord-022353-q2k2krnm	830	32	defense	defense	NN
cord-022353-q2k2krnm	830	33	and	and	CC
cord-022353-q2k2krnm	830	34	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	830	35	disease	disease	NN
cord-022353-q2k2krnm	830	36	(	(	-LRB-
cord-022353-q2k2krnm	830	37	Moser	Moser	NNP
cord-022353-q2k2krnm	830	38	et	et	NNP
cord-022353-q2k2krnm	830	39	al	al	NNP
cord-022353-q2k2krnm	830	40	.	.	.
cord-022353-q2k2krnm	830	41	2004	2004	CD
cord-022353-q2k2krnm	830	42	)	)	-RRB-
cord-022353-q2k2krnm	830	43	.	.	.
cord-022353-q2k2krnm	831	1	Chemokine	Chemokine	NNP
cord-022353-q2k2krnm	831	2	-	-	HYPH
cord-022353-q2k2krnm	831	3	induced	induce	VBN
cord-022353-q2k2krnm	831	4	signaling	signaling	NN
cord-022353-q2k2krnm	831	5	is	be	VBZ
cord-022353-q2k2krnm	831	6	via	via	IN
cord-022353-q2k2krnm	831	7	G	g	NN
cord-022353-q2k2krnm	831	8	-	-	HYPH
cord-022353-q2k2krnm	831	9	protein	protein	NN
cord-022353-q2k2krnm	831	10	coupled	couple	VBN
cord-022353-q2k2krnm	831	11	cell	cell	NN
cord-022353-q2k2krnm	831	12	surface	surface	NN
cord-022353-q2k2krnm	831	13	receptors	receptor	NNS
cord-022353-q2k2krnm	831	14	.	.	.
cord-022353-q2k2krnm	832	1	Although	although	IN
cord-022353-q2k2krnm	832	2	most	most	JJS
cord-022353-q2k2krnm	832	3	chemokines	chemokine	NNS
cord-022353-q2k2krnm	832	4	are	be	VBP
cord-022353-q2k2krnm	832	5	secreted	secrete	VBN
cord-022353-q2k2krnm	832	6	proteins	protein	NNS
cord-022353-q2k2krnm	832	7	,	,	,
cord-022353-q2k2krnm	832	8	two	two	CD
cord-022353-q2k2krnm	832	9	chemokines	chemokine	NNS
cord-022353-q2k2krnm	832	10	,	,	,
cord-022353-q2k2krnm	832	11	CXCL16	CXCL16	NNP
cord-022353-q2k2krnm	832	12	and	and	CC
cord-022353-q2k2krnm	832	13	CX3CL	CX3CL	NNP
cord-022353-q2k2krnm	832	14	1	1	CD
cord-022353-q2k2krnm	832	15	,	,	,
cord-022353-q2k2krnm	832	16	are	be	VBP
cord-022353-q2k2krnm	832	17	membrane	membrane	NN
cord-022353-q2k2krnm	832	18	bound	bind	VBN
cord-022353-q2k2krnm	832	19	.	.	.
cord-022353-q2k2krnm	833	1	Two	two	CD
cord-022353-q2k2krnm	833	2	primary	primary	JJ
cord-022353-q2k2krnm	833	3	subfamilies	subfamily	NNS
cord-022353-q2k2krnm	833	4	are	be	VBP
cord-022353-q2k2krnm	833	5	recognized	recognize	VBN
cord-022353-q2k2krnm	833	6	based	base	VBN
cord-022353-q2k2krnm	833	7	on	on	IN
cord-022353-q2k2krnm	833	8	the	the	DT
cord-022353-q2k2krnm	833	9	arrangement	arrangement	NN
cord-022353-q2k2krnm	833	10	of	of	IN
cord-022353-q2k2krnm	833	11	two	two	CD
cord-022353-q2k2krnm	833	12	NH2-terminal	nh2-terminal	JJ
cord-022353-q2k2krnm	833	13	cysteine	cysteine	NN
cord-022353-q2k2krnm	833	14	residues	residue	NNS
cord-022353-q2k2krnm	833	15	that	that	WDT
cord-022353-q2k2krnm	833	16	are	be	VBP
cord-022353-q2k2krnm	833	17	either	either	RB
cord-022353-q2k2krnm	833	18	located	locate	VBN
cord-022353-q2k2krnm	833	19	adjacent	adjacent	JJ
cord-022353-q2k2krnm	833	20	to	to	IN
cord-022353-q2k2krnm	833	21	each	each	DT
cord-022353-q2k2krnm	833	22	other	other	JJ
cord-022353-q2k2krnm	833	23	(	(	-LRB-
cord-022353-q2k2krnm	833	24	CC	cc	NN
cord-022353-q2k2krnm	833	25	)	)	-RRB-
cord-022353-q2k2krnm	833	26	or	or	CC
cord-022353-q2k2krnm	833	27	are	be	VBP
cord-022353-q2k2krnm	833	28	separated	separate	VBN
cord-022353-q2k2krnm	833	29	by	by	IN
cord-022353-q2k2krnm	833	30	a	a	DT
cord-022353-q2k2krnm	833	31	single	single	JJ
cord-022353-q2k2krnm	833	32	amino	amino	NN
cord-022353-q2k2krnm	833	33	acid	acid	NN
cord-022353-q2k2krnm	833	34	(	(	-LRB-
cord-022353-q2k2krnm	833	35	CXC	CXC	NNP
cord-022353-q2k2krnm	833	36	)	)	-RRB-
cord-022353-q2k2krnm	833	37	.	.	.
cord-022353-q2k2krnm	834	1	Two	two	CD
cord-022353-q2k2krnm	834	2	minor	minor	JJ
cord-022353-q2k2krnm	834	3	subfamilies	subfamily	NNS
cord-022353-q2k2krnm	834	4	include	include	VBP
cord-022353-q2k2krnm	834	5	chemokines	chemokine	NNS
cord-022353-q2k2krnm	834	6	with	with	IN
cord-022353-q2k2krnm	834	7	a	a	DT
cord-022353-q2k2krnm	834	8	single	single	JJ
cord-022353-q2k2krnm	834	9	cysteine	cysteine	NN
cord-022353-q2k2krnm	834	10	resides	reside	VBZ
cord-022353-q2k2krnm	834	11	(	(	-LRB-
cord-022353-q2k2krnm	834	12	XCL1	XCL1	NNP
cord-022353-q2k2krnm	834	13	,	,	,
cord-022353-q2k2krnm	834	14	XCL2	XCL2	NNP
cord-022353-q2k2krnm	834	15	)	)	-RRB-
cord-022353-q2k2krnm	834	16	and	and	CC
cord-022353-q2k2krnm	834	17	a	a	DT
cord-022353-q2k2krnm	834	18	chemokine	chemokine	NN
cord-022353-q2k2krnm	834	19	with	with	IN
cord-022353-q2k2krnm	834	20	three	three	CD
cord-022353-q2k2krnm	834	21	amino	amino	NN
cord-022353-q2k2krnm	834	22	acids	acid	NNS
cord-022353-q2k2krnm	834	23	separating	separate	VBG
cord-022353-q2k2krnm	834	24	the	the	DT
cord-022353-q2k2krnm	834	25	cysteine	cysteine	NN
cord-022353-q2k2krnm	834	26	residues	residue	NNS
cord-022353-q2k2krnm	834	27	(	(	-LRB-
cord-022353-q2k2krnm	834	28	CX3CL1	cx3cl1	NN
cord-022353-q2k2krnm	834	29	)	)	-RRB-
cord-022353-q2k2krnm	834	30	.	.	.
cord-022353-q2k2krnm	835	1	Functionally	functionally	RB
cord-022353-q2k2krnm	835	2	conserved	conserved	JJ
cord-022353-q2k2krnm	835	3	regions	region	NNS
cord-022353-q2k2krnm	835	4	of	of	IN
cord-022353-q2k2krnm	835	5	the	the	DT
cord-022353-q2k2krnm	835	6	N	n	CD
cord-022353-q2k2krnm	835	7	-	-	HYPH
cord-022353-q2k2krnm	835	8	terminus	terminus	NN
cord-022353-q2k2krnm	835	9	of	of	IN
cord-022353-q2k2krnm	835	10	each	each	DT
cord-022353-q2k2krnm	835	11	member	member	NN
cord-022353-q2k2krnm	835	12	mediate	mediate	VB
cord-022353-q2k2krnm	835	13	receptor	receptor	NN
cord-022353-q2k2krnm	835	14	binding	binding	NN
cord-022353-q2k2krnm	835	15	and	and	CC
cord-022353-q2k2krnm	835	16	extracellular	extracellular	JJ
cord-022353-q2k2krnm	835	17	matrix	matrix	NN
cord-022353-q2k2krnm	835	18	fixation	fixation	NN
cord-022353-q2k2krnm	835	19	(	(	-LRB-
cord-022353-q2k2krnm	835	20	or	or	CC
cord-022353-q2k2krnm	835	21	binding	bind	VBG
cord-022353-q2k2krnm	835	22	cell	cell	NN
cord-022353-q2k2krnm	835	23	surface	surface	NN
cord-022353-q2k2krnm	835	24	glycosaminoglycans	glycosaminoglycan	NNS
cord-022353-q2k2krnm	835	25	)	)	-RRB-
cord-022353-q2k2krnm	835	26	.	.	.
cord-022353-q2k2krnm	836	1	Many	many	JJ
cord-022353-q2k2krnm	836	2	chemokines	chemokine	NNS
cord-022353-q2k2krnm	836	3	are	be	VBP
cord-022353-q2k2krnm	836	4	designated	designate	VBN
cord-022353-q2k2krnm	836	5	with	with	IN
cord-022353-q2k2krnm	836	6	a	a	DT
cord-022353-q2k2krnm	836	7	name	name	NN
cord-022353-q2k2krnm	836	8	given	give	VBN
cord-022353-q2k2krnm	836	9	at	at	IN
cord-022353-q2k2krnm	836	10	the	the	DT
cord-022353-q2k2krnm	836	11	time	time	NN
cord-022353-q2k2krnm	836	12	of	of	IN
cord-022353-q2k2krnm	836	13	their	-PRON-	PRP$
cord-022353-q2k2krnm	836	14	identification	identification	NN
cord-022353-q2k2krnm	836	15	;	;	:
cord-022353-q2k2krnm	836	16	all	all	DT
cord-022353-q2k2krnm	836	17	have	have	VBP
cord-022353-q2k2krnm	836	18	also	also	RB
cord-022353-q2k2krnm	836	19	been	be	VBN
cord-022353-q2k2krnm	836	20	assigned	assign	VBN
cord-022353-q2k2krnm	836	21	a	a	DT
cord-022353-q2k2krnm	836	22	name	name	NN
cord-022353-q2k2krnm	836	23	based	base	VBN
cord-022353-q2k2krnm	836	24	on	on	IN
cord-022353-q2k2krnm	836	25	their	-PRON-	PRP$
cord-022353-q2k2krnm	836	26	structural	structural	JJ
cord-022353-q2k2krnm	836	27	motif	motif	NN
cord-022353-q2k2krnm	836	28	(	(	-LRB-
cord-022353-q2k2krnm	836	29	CC	CC	NNP
cord-022353-q2k2krnm	836	30	,	,	,
cord-022353-q2k2krnm	836	31	CXC	CXC	NNP
cord-022353-q2k2krnm	836	32	,	,	,
cord-022353-q2k2krnm	836	33	XC	XC	NNP
cord-022353-q2k2krnm	836	34	,	,	,
cord-022353-q2k2krnm	836	35	CX3C	CX3C	NNP
cord-022353-q2k2krnm	836	36	)	)	-RRB-
cord-022353-q2k2krnm	836	37	followed	follow	VBN
cord-022353-q2k2krnm	836	38	by	by	IN
cord-022353-q2k2krnm	836	39	L	L	NNP
cord-022353-q2k2krnm	836	40	for	for	IN
cord-022353-q2k2krnm	836	41	ligand	ligand	NN
cord-022353-q2k2krnm	836	42	.	.	.
cord-022353-q2k2krnm	837	1	Receptors	receptor	NNS
cord-022353-q2k2krnm	837	2	are	be	VBP
cord-022353-q2k2krnm	837	3	heterotrimers	heterotrimer	NNS
cord-022353-q2k2krnm	837	4	and	and	CC
cord-022353-q2k2krnm	837	5	their	-PRON-	PRP$
cord-022353-q2k2krnm	837	6	activated	activate	VBN
cord-022353-q2k2krnm	837	7	G	g	NN
cord-022353-q2k2krnm	837	8	-	-	HYPH
cord-022353-q2k2krnm	837	9	protein	protein	NN
cord-022353-q2k2krnm	837	10	subunits	subunit	NNS
cord-022353-q2k2krnm	837	11	stimulate	stimulate	VBP
cord-022353-q2k2krnm	837	12	phospholipase	phospholipase	NN
cord-022353-q2k2krnm	837	13	C[3	C[3	NNP
cord-022353-q2k2krnm	837	14	,	,	,
cord-022353-q2k2krnm	837	15	PIKs	PIKs	NNPS
cord-022353-q2k2krnm	837	16	,	,	,
cord-022353-q2k2krnm	837	17	and	and	CC
cord-022353-q2k2krnm	837	18	c	c	LS
cord-022353-q2k2krnm	837	19	-	-	HYPH
cord-022353-q2k2krnm	837	20	Src	Src	NNP
cord-022353-q2k2krnm	837	21	tyrosine	tyrosine	NN
cord-022353-q2k2krnm	837	22	kinases	kinase	NNS
cord-022353-q2k2krnm	838	1	(	(	-LRB-
cord-022353-q2k2krnm	838	2	Moser	Moser	NNP
cord-022353-q2k2krnm	838	3	et	et	NNP
cord-022353-q2k2krnm	838	4	al	al	NNP
cord-022353-q2k2krnm	838	5	.	.	.
cord-022353-q2k2krnm	838	6	2004	2004	CD
cord-022353-q2k2krnm	838	7	)	)	-RRB-
cord-022353-q2k2krnm	838	8	.	.	.
cord-022353-q2k2krnm	839	1	Receptors	receptor	NNS
cord-022353-q2k2krnm	839	2	are	be	VBP
cord-022353-q2k2krnm	839	3	designated	designate	VBN
cord-022353-q2k2krnm	839	4	by	by	IN
cord-022353-q2k2krnm	839	5	the	the	DT
cord-022353-q2k2krnm	839	6	type	type	NN
cord-022353-q2k2krnm	839	7	of	of	IN
cord-022353-q2k2krnm	839	8	chemokine	chemokine	NN
cord-022353-q2k2krnm	839	9	they	-PRON-	PRP
cord-022353-q2k2krnm	839	10	bind	bind	VBP
cord-022353-q2k2krnm	839	11	(	(	-LRB-
cord-022353-q2k2krnm	839	12	i.e.	i.e.	FW
cord-022353-q2k2krnm	839	13	,	,	,
cord-022353-q2k2krnm	839	14	CXC	CXC	NNP
cord-022353-q2k2krnm	839	15	,	,	,
cord-022353-q2k2krnm	839	16	CC	CC	NNP
cord-022353-q2k2krnm	839	17	,	,	,
cord-022353-q2k2krnm	839	18	XC	XC	NNP
cord-022353-q2k2krnm	839	19	,	,	,
cord-022353-q2k2krnm	839	20	or	or	CC
cord-022353-q2k2krnm	839	21	CX3C	CX3C	NNP
cord-022353-q2k2krnm	839	22	)	)	-RRB-
cord-022353-q2k2krnm	839	23	,	,	,
cord-022353-q2k2krnm	839	24	followed	follow	VBN
cord-022353-q2k2krnm	839	25	by	by	IN
cord-022353-q2k2krnm	839	26	R.	R.	NNP
cord-022353-q2k2krnm	839	27	Mice	Mice	NNP
cord-022353-q2k2krnm	839	28	lack	lack	VBP
cord-022353-q2k2krnm	839	29	the	the	DT
cord-022353-q2k2krnm	839	30	CXCR1	cxcr1	NN
cord-022353-q2k2krnm	839	31	family	family	NN
cord-022353-q2k2krnm	839	32	of	of	IN
cord-022353-q2k2krnm	839	33	chemokines	chemokine	NNS
cord-022353-q2k2krnm	839	34	and	and	CC
cord-022353-q2k2krnm	839	35	receptors	receptor	NNS
cord-022353-q2k2krnm	839	36	found	find	VBN
cord-022353-q2k2krnm	839	37	in	in	IN
cord-022353-q2k2krnm	839	38	humans	human	NNS
cord-022353-q2k2krnm	839	39	.	.	.
cord-022353-q2k2krnm	840	1	Table	table	NN
cord-022353-q2k2krnm	840	2	6	6	CD
cord-022353-q2k2krnm	840	3	-8	-8	NNP
cord-022353-q2k2krnm	840	4	lists	list	NNS
cord-022353-q2k2krnm	840	5	the	the	DT
cord-022353-q2k2krnm	840	6	murine	murine	JJ
cord-022353-q2k2krnm	840	7	chemokine	chemokine	NN
cord-022353-q2k2krnm	840	8	receptors	receptor	NNS
cord-022353-q2k2krnm	840	9	and	and	CC
cord-022353-q2k2krnm	840	10	the	the	DT
cord-022353-q2k2krnm	840	11	known	know	VBN
cord-022353-q2k2krnm	840	12	ligands	ligand	NNS
cord-022353-q2k2krnm	840	13	.	.	.
cord-022353-q2k2krnm	841	1	Table	table	NN
cord-022353-q2k2krnm	841	2	6	6	CD
cord-022353-q2k2krnm	841	3	-3	-3	NNP
cord-022353-q2k2krnm	841	4	lists	list	VBZ
cord-022353-q2k2krnm	841	5	the	the	DT
cord-022353-q2k2krnm	841	6	murine	murine	JJ
cord-022353-q2k2krnm	841	7	chemokines	chemokine	NNS
cord-022353-q2k2krnm	841	8	for	for	IN
cord-022353-q2k2krnm	841	9	which	which	WDT
cord-022353-q2k2krnm	841	10	there	there	EX
cord-022353-q2k2krnm	841	11	are	be	VBP
cord-022353-q2k2krnm	841	12	either	either	DT
cord-022353-q2k2krnm	841	13	commercial	commercial	JJ
cord-022353-q2k2krnm	841	14	test	test	NN
cord-022353-q2k2krnm	841	15	kits	kit	NNS
cord-022353-q2k2krnm	841	16	or	or	CC
cord-022353-q2k2krnm	841	17	matched	match	VBN
cord-022353-q2k2krnm	841	18	antibodies	antibody	NNS
cord-022353-q2k2krnm	841	19	for	for	IN
cord-022353-q2k2krnm	841	20	kit	kit	NN
cord-022353-q2k2krnm	841	21	development	development	NN
cord-022353-q2k2krnm	841	22	.	.	.
cord-022353-q2k2krnm	842	1	Two	two	CD
cord-022353-q2k2krnm	842	2	main	main	JJ
cord-022353-q2k2krnm	842	3	functional	functional	JJ
cord-022353-q2k2krnm	842	4	groups	group	NNS
cord-022353-q2k2krnm	842	5	define	define	VBP
cord-022353-q2k2krnm	842	6	chemokines	chemokine	NNS
cord-022353-q2k2krnm	842	7	.	.	.
cord-022353-q2k2krnm	843	1	Inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	843	2	chemokines	chemokine	NNS
cord-022353-q2k2krnm	843	3	recruit	recruit	VBP
cord-022353-q2k2krnm	843	4	effector	effector	NN
cord-022353-q2k2krnm	843	5	leukocytes	leukocyte	NNS
cord-022353-q2k2krnm	843	6	to	to	IN
cord-022353-q2k2krnm	843	7	sites	site	NNS
cord-022353-q2k2krnm	843	8	of	of	IN
cord-022353-q2k2krnm	843	9	infection	infection	NN
cord-022353-q2k2krnm	843	10	,	,	,
cord-022353-q2k2krnm	843	11	inflammation	inflammation	NN
cord-022353-q2k2krnm	843	12	,	,	,
cord-022353-q2k2krnm	843	13	and	and	CC
cord-022353-q2k2krnm	843	14	repair	repair	NN
cord-022353-q2k2krnm	843	15	.	.	.
cord-022353-q2k2krnm	844	1	Homeostatic	homeostatic	JJ
cord-022353-q2k2krnm	844	2	chemokines	chemokine	NNS
cord-022353-q2k2krnm	844	3	control	control	VBP
cord-022353-q2k2krnm	844	4	the	the	DT
cord-022353-q2k2krnm	844	5	navigation	navigation	NN
cord-022353-q2k2krnm	844	6	of	of	IN
cord-022353-q2k2krnm	844	7	leukocytes	leukocyte	NNS
cord-022353-q2k2krnm	844	8	during	during	IN
cord-022353-q2k2krnm	844	9	hematopoiesis	hematopoiesis	NN
cord-022353-q2k2krnm	844	10	in	in	IN
cord-022353-q2k2krnm	844	11	the	the	DT
cord-022353-q2k2krnm	844	12	bone	bone	NN
cord-022353-q2k2krnm	844	13	marrow	marrow	NN
cord-022353-q2k2krnm	844	14	and	and	CC
cord-022353-q2k2krnm	844	15	thymus	thymus	NN
cord-022353-q2k2krnm	844	16	,	,	,
cord-022353-q2k2krnm	844	17	control	control	NN
cord-022353-q2k2krnm	844	18	homing	homing	NN
cord-022353-q2k2krnm	844	19	of	of	IN
cord-022353-q2k2krnm	844	20	cells	cell	NNS
cord-022353-q2k2krnm	844	21	to	to	IN
cord-022353-q2k2krnm	844	22	spleen	spleen	NN
cord-022353-q2k2krnm	844	23	,	,	,
cord-022353-q2k2krnm	844	24	lymph	lymph	NN
cord-022353-q2k2krnm	844	25	nodes	node	NNS
cord-022353-q2k2krnm	844	26	,	,	,
cord-022353-q2k2krnm	844	27	and	and	CC
cord-022353-q2k2krnm	844	28	Peyer	Peyer	NNP
cord-022353-q2k2krnm	844	29	's	's	POS
cord-022353-q2k2krnm	844	30	patches	patch	NNS
cord-022353-q2k2krnm	844	31	during	during	IN
cord-022353-q2k2krnm	844	32	the	the	DT
cord-022353-q2k2krnm	844	33	adaptive	adaptive	JJ
cord-022353-q2k2krnm	844	34	immune	immune	JJ
cord-022353-q2k2krnm	844	35	response	response	NN
cord-022353-q2k2krnm	844	36	and	and	CC
cord-022353-q2k2krnm	844	37	control	control	NN
cord-022353-q2k2krnm	844	38	immune	immune	JJ
cord-022353-q2k2krnm	844	39	surveillance	surveillance	NN
cord-022353-q2k2krnm	844	40	in	in	IN
cord-022353-q2k2krnm	844	41	peripheral	peripheral	JJ
cord-022353-q2k2krnm	844	42	tissues	tissue	NNS
cord-022353-q2k2krnm	844	43	.	.	.
cord-022353-q2k2krnm	845	1	Some	some	DT
cord-022353-q2k2krnm	845	2	chemokines	chemokine	NNS
cord-022353-q2k2krnm	845	3	participate	participate	VBP
cord-022353-q2k2krnm	845	4	in	in	IN
cord-022353-q2k2krnm	845	5	both	both	DT
cord-022353-q2k2krnm	845	6	inflammation	inflammation	NN
cord-022353-q2k2krnm	845	7	and	and	CC
cord-022353-q2k2krnm	845	8	homeostasis	homeostasis	NN
cord-022353-q2k2krnm	845	9	and	and	CC
cord-022353-q2k2krnm	845	10	are	be	VBP
cord-022353-q2k2krnm	845	11	called	call	VBN
cord-022353-q2k2krnm	845	12	dual	dual	JJ
cord-022353-q2k2krnm	845	13	-	-	HYPH
cord-022353-q2k2krnm	845	14	function	function	NN
cord-022353-q2k2krnm	845	15	chemokines	chemokine	NNS
cord-022353-q2k2krnm	845	16	.	.	.
cord-022353-q2k2krnm	846	1	Many	many	JJ
cord-022353-q2k2krnm	846	2	dual	dual	JJ
cord-022353-q2k2krnm	846	3	function	function	NN
cord-022353-q2k2krnm	846	4	chemokines	chemokine	NNS
cord-022353-q2k2krnm	846	5	are	be	VBP
cord-022353-q2k2krnm	846	6	highly	highly	RB
cord-022353-q2k2krnm	846	7	selective	selective	JJ
cord-022353-q2k2krnm	846	8	for	for	IN
cord-022353-q2k2krnm	846	9	the	the	DT
cord-022353-q2k2krnm	846	10	recruitment	recruitment	NN
cord-022353-q2k2krnm	846	11	of	of	IN
cord-022353-q2k2krnm	846	12	T	T	NNP
cord-022353-q2k2krnm	846	13	cells	cell	NNS
cord-022353-q2k2krnm	846	14	.	.	.
cord-022353-q2k2krnm	847	1	Other	other	JJ
cord-022353-q2k2krnm	847	2	chemokines	chemokine	NNS
cord-022353-q2k2krnm	847	3	have	have	VBP
cord-022353-q2k2krnm	847	4	ill	ill	RB
cord-022353-q2k2krnm	847	5	-	-	HYPH
cord-022353-q2k2krnm	847	6	defined	define	VBN
cord-022353-q2k2krnm	847	7	functions	function	NNS
cord-022353-q2k2krnm	847	8	regarding	regard	VBG
cord-022353-q2k2krnm	847	9	homeostasis	homeostasis	NN
cord-022353-q2k2krnm	847	10	and	and	CC
cord-022353-q2k2krnm	847	11	inflammation	inflammation	NN
cord-022353-q2k2krnm	847	12	but	but	CC
cord-022353-q2k2krnm	847	13	participate	participate	VBP
cord-022353-q2k2krnm	847	14	in	in	IN
cord-022353-q2k2krnm	847	15	other	other	JJ
cord-022353-q2k2krnm	847	16	vital	vital	JJ
cord-022353-q2k2krnm	847	17	activities	activity	NNS
cord-022353-q2k2krnm	847	18	such	such	JJ
cord-022353-q2k2krnm	847	19	as	as	IN
cord-022353-q2k2krnm	847	20	the	the	DT
cord-022353-q2k2krnm	847	21	role	role	NN
cord-022353-q2k2krnm	847	22	of	of	IN
cord-022353-q2k2krnm	847	23	PF4	pf4	NN
cord-022353-q2k2krnm	847	24	(	(	-LRB-
cord-022353-q2k2krnm	847	25	CXCL4	cxcl4	NN
cord-022353-q2k2krnm	847	26	)	)	-RRB-
cord-022353-q2k2krnm	847	27	in	in	IN
cord-022353-q2k2krnm	847	28	thrombosis	thrombosis	NN
cord-022353-q2k2krnm	847	29	and	and	CC
cord-022353-q2k2krnm	847	30	the	the	DT
cord-022353-q2k2krnm	847	31	role	role	NN
cord-022353-q2k2krnm	847	32	of	of	IN
cord-022353-q2k2krnm	847	33	CXCL	CXCL	NNP
cord-022353-q2k2krnm	847	34	10	10	CD
cord-022353-q2k2krnm	847	35	in	in	IN
cord-022353-q2k2krnm	847	36	gut	gut	NN
cord-022353-q2k2krnm	847	37	epithelial	epithelial	JJ
cord-022353-q2k2krnm	847	38	cell	cell	NN
cord-022353-q2k2krnm	847	39	turnover	turnover	NN
cord-022353-q2k2krnm	848	1	(	(	-LRB-
cord-022353-q2k2krnm	848	2	Cliffe	Cliffe	NNP
cord-022353-q2k2krnm	848	3	et	et	NNP
cord-022353-q2k2krnm	848	4	al	al	NNP
cord-022353-q2k2krnm	848	5	.	.	NNP
cord-022353-q2k2krnm	848	6	2005	2005	CD
cord-022353-q2k2krnm	848	7	)	)	-RRB-
cord-022353-q2k2krnm	848	8	.	.	.
cord-022353-q2k2krnm	849	1	Most	Most	JJS
cord-022353-q2k2krnm	849	2	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	849	3	chemokines	chemokine	NNS
cord-022353-q2k2krnm	849	4	are	be	VBP
cord-022353-q2k2krnm	849	5	thought	think	VBN
cord-022353-q2k2krnm	849	6	to	to	TO
cord-022353-q2k2krnm	849	7	be	be	VB
cord-022353-q2k2krnm	849	8	induced	induce	VBN
cord-022353-q2k2krnm	849	9	and	and	CC
cord-022353-q2k2krnm	849	10	the	the	DT
cord-022353-q2k2krnm	849	11	variety	variety	NN
cord-022353-q2k2krnm	849	12	of	of	IN
cord-022353-q2k2krnm	849	13	stimuli	stimulus	NNS
cord-022353-q2k2krnm	849	14	that	that	WDT
cord-022353-q2k2krnm	849	15	induce	induce	VBP
cord-022353-q2k2krnm	849	16	their	-PRON-	PRP$
cord-022353-q2k2krnm	849	17	expression	expression	NN
cord-022353-q2k2krnm	849	18	is	be	VBZ
cord-022353-q2k2krnm	849	19	broad	broad	JJ
cord-022353-q2k2krnm	849	20	.	.	.
cord-022353-q2k2krnm	850	1	By	by	IN
cord-022353-q2k2krnm	850	2	contrast	contrast	NN
cord-022353-q2k2krnm	850	3	most	most	RBS
cord-022353-q2k2krnm	850	4	homeostatic	homeostatic	JJ
cord-022353-q2k2krnm	850	5	chemokines	chemokine	NNS
cord-022353-q2k2krnm	850	6	are	be	VBP
cord-022353-q2k2krnm	850	7	thought	think	VBN
cord-022353-q2k2krnm	850	8	to	to	TO
cord-022353-q2k2krnm	850	9	be	be	VB
cord-022353-q2k2krnm	850	10	constitutively	constitutively	RB
cord-022353-q2k2krnm	850	11	expressed	express	VBN
cord-022353-q2k2krnm	850	12	.	.	.
cord-022353-q2k2krnm	851	1	An	an	DT
cord-022353-q2k2krnm	851	2	exception	exception	NN
cord-022353-q2k2krnm	851	3	is	be	VBZ
cord-022353-q2k2krnm	851	4	the	the	DT
cord-022353-q2k2krnm	851	5	inducing	inducing	JJ
cord-022353-q2k2krnm	851	6	effect	effect	NN
cord-022353-q2k2krnm	851	7	of	of	IN
cord-022353-q2k2krnm	851	8	lymphotoxin	lymphotoxin	NN
cord-022353-q2k2krnm	851	9	and	and	CC
cord-022353-q2k2krnm	851	10	TNF-~	TNF-~	NNP
cord-022353-q2k2krnm	851	11	on	on	IN
cord-022353-q2k2krnm	851	12	B	b	NN
cord-022353-q2k2krnm	851	13	-	-	HYPH
cord-022353-q2k2krnm	851	14	cell	cell	NN
cord-022353-q2k2krnm	851	15	attracting	attract	VBG
cord-022353-q2k2krnm	851	16	chemokine-1	chemokine-1	NNP
cord-022353-q2k2krnm	851	17	(	(	-LRB-
cord-022353-q2k2krnm	851	18	BCA	BCA	NNP
cord-022353-q2k2krnm	851	19	-	-	HYPH
cord-022353-q2k2krnm	851	20	I	I	NNP
cord-022353-q2k2krnm	851	21	,	,	,
cord-022353-q2k2krnm	851	22	CXCL13	CXCL13	NNP
cord-022353-q2k2krnm	851	23	)	)	-RRB-
cord-022353-q2k2krnm	851	24	,	,	,
cord-022353-q2k2krnm	851	25	CCL19	CCL19	NNP
cord-022353-q2k2krnm	851	26	,	,	,
cord-022353-q2k2krnm	851	27	and	and	CC
cord-022353-q2k2krnm	851	28	secondary	secondary	JJ
cord-022353-q2k2krnm	851	29	lymphoid	lymphoid	JJ
cord-022353-q2k2krnm	851	30	tissue	tissue	NN
cord-022353-q2k2krnm	851	31	chemokine	chemokine	NN
cord-022353-q2k2krnm	851	32	(	(	-LRB-
cord-022353-q2k2krnm	851	33	SLC	SLC	NNP
cord-022353-q2k2krnm	851	34	,	,	,
cord-022353-q2k2krnm	851	35	CCL21	CCL21	NNP
cord-022353-q2k2krnm	851	36	)	)	-RRB-
cord-022353-q2k2krnm	851	37	,	,	,
cord-022353-q2k2krnm	851	38	which	which	WDT
cord-022353-q2k2krnm	851	39	also	also	RB
cord-022353-q2k2krnm	851	40	participate	participate	VBP
cord-022353-q2k2krnm	851	41	in	in	IN
cord-022353-q2k2krnm	851	42	inflammation	inflammation	NN
cord-022353-q2k2krnm	851	43	.	.	.
cord-022353-q2k2krnm	852	1	Leukocytes	Leukocytes	NNP
cord-022353-q2k2krnm	852	2	also	also	RB
cord-022353-q2k2krnm	852	3	release	release	VBP
cord-022353-q2k2krnm	852	4	several	several	JJ
cord-022353-q2k2krnm	852	5	kinds	kind	NNS
cord-022353-q2k2krnm	852	6	of	of	IN
cord-022353-q2k2krnm	852	7	proteases	protease	NNS
cord-022353-q2k2krnm	852	8	that	that	WDT
cord-022353-q2k2krnm	852	9	degrade	degrade	VBP
cord-022353-q2k2krnm	852	10	chemokines	chemokine	NNS
cord-022353-q2k2krnm	852	11	at	at	IN
cord-022353-q2k2krnm	852	12	their	-PRON-	PRP$
cord-022353-q2k2krnm	852	13	N	n	CD
cord-022353-q2k2krnm	852	14	-	-	HYPH
cord-022353-q2k2krnm	852	15	terminus	terminus	NN
cord-022353-q2k2krnm	852	16	,	,	,
cord-022353-q2k2krnm	852	17	resulting	result	VBG
cord-022353-q2k2krnm	852	18	in	in	IN
cord-022353-q2k2krnm	852	19	the	the	DT
cord-022353-q2k2krnm	852	20	loss	loss	NN
cord-022353-q2k2krnm	852	21	of	of	IN
cord-022353-q2k2krnm	852	22	receptor	receptor	NN
cord-022353-q2k2krnm	852	23	binding	binding	NN
cord-022353-q2k2krnm	852	24	,	,	,
cord-022353-q2k2krnm	852	25	antagonist	antagonist	NN
cord-022353-q2k2krnm	852	26	generation	generation	NN
cord-022353-q2k2krnm	852	27	,	,	,
cord-022353-q2k2krnm	852	28	or	or	CC
cord-022353-q2k2krnm	852	29	enhancing	enhance	VBG
cord-022353-q2k2krnm	852	30	their	-PRON-	PRP$
cord-022353-q2k2krnm	852	31	biologic	biologic	JJ
cord-022353-q2k2krnm	852	32	function	function	NN
cord-022353-q2k2krnm	852	33	.	.	.
cord-022353-q2k2krnm	853	1	Leukocyte	Leukocyte	NNP
cord-022353-q2k2krnm	853	2	CD26	CD26	NNP
cord-022353-q2k2krnm	853	3	,	,	,
cord-022353-q2k2krnm	853	4	dipeptidyl	dipeptidyl	JJ
cord-022353-q2k2krnm	853	5	peptidase	peptidase	NN
cord-022353-q2k2krnm	853	6	IV	IV	NNP
cord-022353-q2k2krnm	853	7	is	be	VBZ
cord-022353-q2k2krnm	853	8	known	know	VBN
cord-022353-q2k2krnm	853	9	to	to	TO
cord-022353-q2k2krnm	853	10	act	act	VB
cord-022353-q2k2krnm	853	11	on	on	IN
cord-022353-q2k2krnm	853	12	CXCL9	CXCL9	NNP
cord-022353-q2k2krnm	853	13	,	,	,
cord-022353-q2k2krnm	853	14	CXCL10	CXCL10	NNP
cord-022353-q2k2krnm	853	15	,	,	,
cord-022353-q2k2krnm	853	16	CXCL11	CXCL11	NNP
cord-022353-q2k2krnm	853	17	,	,	,
cord-022353-q2k2krnm	853	18	and	and	CC
cord-022353-q2k2krnm	853	19	CXCL12	CXCL12	NNP
cord-022353-q2k2krnm	853	20	.	.	.
cord-022353-q2k2krnm	854	1	Murine	murine	JJ
cord-022353-q2k2krnm	854	2	sulphostin	sulphostin	NN
cord-022353-q2k2krnm	854	3	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	854	4	the	the	DT
cord-022353-q2k2krnm	854	5	action	action	NN
cord-022353-q2k2krnm	854	6	of	of	IN
cord-022353-q2k2krnm	854	7	CD26	CD26	NNP
cord-022353-q2k2krnm	854	8	and	and	CC
cord-022353-q2k2krnm	854	9	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	854	10	G	G	NNP
cord-022353-q2k2krnm	854	11	-	-	HYPH
cord-022353-q2k2krnm	854	12	CSF	CSF	NNP
cord-022353-q2k2krnm	854	13	and	and	CC
cord-022353-q2k2krnm	854	14	granulopoiesis	granulopoiesis	NNP
cord-022353-q2k2krnm	854	15	(	(	-LRB-
cord-022353-q2k2krnm	854	16	Abe	Abe	NNP
cord-022353-q2k2krnm	854	17	et	et	NNP
cord-022353-q2k2krnm	854	18	al	al	NNP
cord-022353-q2k2krnm	854	19	.	.	NNP
cord-022353-q2k2krnm	854	20	2005	2005	CD
cord-022353-q2k2krnm	854	21	)	)	-RRB-
cord-022353-q2k2krnm	854	22	.	.	.
cord-022353-q2k2krnm	855	1	Matrix	Matrix	NNP
cord-022353-q2k2krnm	855	2	metalloproteases	metalloprotease	NNS
cord-022353-q2k2krnm	855	3	(	(	-LRB-
cord-022353-q2k2krnm	855	4	MMPs	MMPs	NNP
cord-022353-q2k2krnm	855	5	)	)	-RRB-
cord-022353-q2k2krnm	855	6	are	be	VBP
cord-022353-q2k2krnm	855	7	enzymes	enzyme	NNS
cord-022353-q2k2krnm	855	8	that	that	WDT
cord-022353-q2k2krnm	855	9	degrade	degrade	VBP
cord-022353-q2k2krnm	855	10	extracellular	extracellular	JJ
cord-022353-q2k2krnm	855	11	matrix	matrix	NN
cord-022353-q2k2krnm	855	12	proteins	protein	NNS
cord-022353-q2k2krnm	855	13	,	,	,
cord-022353-q2k2krnm	855	14	including	include	VBG
cord-022353-q2k2krnm	855	15	stromal	stromal	JJ
cord-022353-q2k2krnm	855	16	cell	cell	NN
cord-022353-q2k2krnm	855	17	derived	derive	VBN
cord-022353-q2k2krnm	855	18	factor-1	factor-1	NNP
cord-022353-q2k2krnm	855	19	(	(	-LRB-
cord-022353-q2k2krnm	855	20	SDF-1	SDF-1	NNP
cord-022353-q2k2krnm	855	21	,	,	,
cord-022353-q2k2krnm	855	22	CXCL12	CXCL12	NNP
cord-022353-q2k2krnm	855	23	)	)	-RRB-
cord-022353-q2k2krnm	855	24	and	and	CC
cord-022353-q2k2krnm	855	25	MCP-1	MCP-1	NNP
cord-022353-q2k2krnm	855	26	.	.	.
cord-022353-q2k2krnm	856	1	Table	table	NN
cord-022353-q2k2krnm	856	2	6	6	CD
cord-022353-q2k2krnm	857	1	-3	-3	NNP
cord-022353-q2k2krnm	857	2	lists	list	VBZ
cord-022353-q2k2krnm	857	3	the	the	DT
cord-022353-q2k2krnm	857	4	murine	murine	JJ
cord-022353-q2k2krnm	857	5	MMPs	mmp	NNS
cord-022353-q2k2krnm	857	6	that	that	WDT
cord-022353-q2k2krnm	857	7	can	can	MD
cord-022353-q2k2krnm	857	8	be	be	VB
cord-022353-q2k2krnm	857	9	quantified	quantify	VBN
cord-022353-q2k2krnm	857	10	by	by	IN
cord-022353-q2k2krnm	857	11	commercially	commercially	RB
cord-022353-q2k2krnm	857	12	available	available	JJ
cord-022353-q2k2krnm	857	13	ELISA	ELISA	NNP
cord-022353-q2k2krnm	857	14	kits	kit	NNS
cord-022353-q2k2krnm	857	15	.	.	.
cord-022353-q2k2krnm	858	1	In	in	IN
cord-022353-q2k2krnm	858	2	addition	addition	NN
cord-022353-q2k2krnm	858	3	to	to	IN
cord-022353-q2k2krnm	858	4	MMPs	mmp	NNS
cord-022353-q2k2krnm	858	5	,	,	,
cord-022353-q2k2krnm	858	6	cathepsins	cathepsin	NNS
cord-022353-q2k2krnm	858	7	have	have	VBP
cord-022353-q2k2krnm	858	8	been	be	VBN
cord-022353-q2k2krnm	858	9	shown	show	VBN
cord-022353-q2k2krnm	858	10	to	to	TO
cord-022353-q2k2krnm	858	11	modify	modify	VB
cord-022353-q2k2krnm	858	12	chemokines	chemokine	NNS
cord-022353-q2k2krnm	858	13	.	.	.
cord-022353-q2k2krnm	859	1	Table	table	NN
cord-022353-q2k2krnm	859	2	6	6	CD
cord-022353-q2k2krnm	859	3	-9	-9	NNP
cord-022353-q2k2krnm	859	4	lists	list	VBZ
cord-022353-q2k2krnm	859	5	the	the	DT
cord-022353-q2k2krnm	859	6	murine	murine	JJ
cord-022353-q2k2krnm	859	7	chemokines	chemokine	NNS
cord-022353-q2k2krnm	859	8	and	and	CC
cord-022353-q2k2krnm	859	9	the	the	DT
cord-022353-q2k2krnm	859	10	proteases	protease	NNS
cord-022353-q2k2krnm	859	11	that	that	WDT
cord-022353-q2k2krnm	859	12	degrade	degrade	VBP
cord-022353-q2k2krnm	859	13	them	-PRON-	PRP
cord-022353-q2k2krnm	859	14	and	and	CC
cord-022353-q2k2krnm	859	15	stimuli	stimulus	NNS
cord-022353-q2k2krnm	859	16	that	that	WDT
cord-022353-q2k2krnm	859	17	induce	induce	VBP
cord-022353-q2k2krnm	859	18	them	-PRON-	PRP
cord-022353-q2k2krnm	859	19	.	.	.
cord-022353-q2k2krnm	860	1	Certain	certain	JJ
cord-022353-q2k2krnm	860	2	chemokines	chemokine	NNS
cord-022353-q2k2krnm	860	3	may	may	MD
cord-022353-q2k2krnm	860	4	antagonize	antagonize	VB
cord-022353-q2k2krnm	860	5	the	the	DT
cord-022353-q2k2krnm	860	6	activity	activity	NN
cord-022353-q2k2krnm	860	7	of	of	IN
cord-022353-q2k2krnm	860	8	other	other	JJ
cord-022353-q2k2krnm	860	9	chemokines	chemokine	NNS
cord-022353-q2k2krnm	860	10	;	;	:
cord-022353-q2k2krnm	860	11	for	for	IN
cord-022353-q2k2krnm	860	12	instance	instance	NN
cord-022353-q2k2krnm	860	13	,	,	,
cord-022353-q2k2krnm	860	14	three	three	CD
cord-022353-q2k2krnm	860	15	agonists	agonist	NNS
cord-022353-q2k2krnm	860	16	for	for	IN
cord-022353-q2k2krnm	860	17	the	the	DT
cord-022353-q2k2krnm	860	18	receptor	receptor	NN
cord-022353-q2k2krnm	860	19	CXCR3	cxcr3	NN
cord-022353-q2k2krnm	860	20	are	be	VBP
cord-022353-q2k2krnm	860	21	also	also	RB
cord-022353-q2k2krnm	860	22	antagonists	antagonist	NNS
cord-022353-q2k2krnm	860	23	for	for	IN
cord-022353-q2k2krnm	860	24	receptor	receptor	NN
cord-022353-q2k2krnm	860	25	CCR3	CCR3	NNP
cord-022353-q2k2krnm	860	26	(	(	-LRB-
cord-022353-q2k2krnm	860	27	which	which	WDT
cord-022353-q2k2krnm	860	28	is	be	VBZ
cord-022353-q2k2krnm	860	29	agonized	agonize	VBN
cord-022353-q2k2krnm	860	30	by	by	IN
cord-022353-q2k2krnm	860	31	eotaxin	eotaxin	NNP
cord-022353-q2k2krnm	860	32	[	[	-LRB-
cord-022353-q2k2krnm	860	33	CCL11	CCL11	NNP
cord-022353-q2k2krnm	860	34	]	]	-RRB-
cord-022353-q2k2krnm	860	35	)	)	-RRB-
cord-022353-q2k2krnm	860	36	.	.	.
cord-022353-q2k2krnm	861	1	Because	because	IN
cord-022353-q2k2krnm	861	2	CXCR3	CXCR3	NNP
cord-022353-q2k2krnm	861	3	and	and	CC
cord-022353-q2k2krnm	861	4	CCR3	CCR3	NNP
cord-022353-q2k2krnm	861	5	are	be	VBP
cord-022353-q2k2krnm	861	6	differentially	differentially	RB
cord-022353-q2k2krnm	861	7	expressed	express	VBN
cord-022353-q2k2krnm	861	8	on	on	IN
cord-022353-q2k2krnm	861	9	TH1	TH1	NNP
cord-022353-q2k2krnm	861	10	and	and	CC
cord-022353-q2k2krnm	861	11	TH2	TH2	NNP
cord-022353-q2k2krnm	861	12	cells	cell	NNS
cord-022353-q2k2krnm	861	13	,	,	,
cord-022353-q2k2krnm	861	14	these	these	DT
cord-022353-q2k2krnm	861	15	chemokines	chemokine	NNS
cord-022353-q2k2krnm	861	16	[	[	-LRB-
cord-022353-q2k2krnm	861	17	monokine	monokine	NN
cord-022353-q2k2krnm	861	18	induced	induce	VBN
cord-022353-q2k2krnm	861	19	by	by	IN
cord-022353-q2k2krnm	861	20	IFN	IFN	NNP
cord-022353-q2k2krnm	861	21	-	-	HYPH
cord-022353-q2k2krnm	861	22	y	y	NNP
cord-022353-q2k2krnm	861	23	(	(	-LRB-
cord-022353-q2k2krnm	861	24	MIG	MIG	NNP
cord-022353-q2k2krnm	861	25	/	/	SYM
cord-022353-q2k2krnm	861	26	CXCL9	CXCL9	NNP
cord-022353-q2k2krnm	861	27	)	)	-RRB-
cord-022353-q2k2krnm	861	28	,	,	,
cord-022353-q2k2krnm	861	29	IFNinducible	IFNinducible	NNP
cord-022353-q2k2krnm	861	30	protein-10	protein-10	CD
cord-022353-q2k2krnm	861	31	(	(	-LRB-
cord-022353-q2k2krnm	861	32	IP-10	IP-10	NNP
cord-022353-q2k2krnm	861	33	/	/	SYM
cord-022353-q2k2krnm	861	34	CXCL10	CXCL10	NNP
cord-022353-q2k2krnm	861	35	)	)	-RRB-
cord-022353-q2k2krnm	861	36	,	,	,
cord-022353-q2k2krnm	861	37	and	and	CC
cord-022353-q2k2krnm	861	38	IFN	IFN	NNP
cord-022353-q2k2krnm	861	39	-	-	HYPH
cord-022353-q2k2krnm	861	40	inducible	inducible	JJ
cord-022353-q2k2krnm	861	41	T	t	NN
cord-022353-q2k2krnm	861	42	-	-	HYPH
cord-022353-q2k2krnm	861	43	cell	cell	NN
cord-022353-q2k2krnm	861	44	chemoattractant	chemoattractant	NN
cord-022353-q2k2krnm	861	45	(	(	-LRB-
cord-022353-q2k2krnm	861	46	I	I	NNP
cord-022353-q2k2krnm	861	47	-	-	HYPH
cord-022353-q2k2krnm	861	48	TAC	TAC	NNP
cord-022353-q2k2krnm	861	49	/	/	SYM
cord-022353-q2k2krnm	861	50	CXCL11	CXCL11	NNP
cord-022353-q2k2krnm	861	51	)	)	-RRB-
cord-022353-q2k2krnm	861	52	]	]	-RRB-
cord-022353-q2k2krnm	861	53	modulate	modulate	VB
cord-022353-q2k2krnm	861	54	the	the	DT
cord-022353-q2k2krnm	861	55	TH	TH	NNP
cord-022353-q2k2krnm	861	56	subpopulation	subpopulation	NN
cord-022353-q2k2krnm	861	57	allowed	allow	VBN
cord-022353-q2k2krnm	861	58	to	to	TO
cord-022353-q2k2krnm	861	59	enter	enter	VB
cord-022353-q2k2krnm	861	60	tissue	tissue	NN
cord-022353-q2k2krnm	861	61	sites	site	NNS
cord-022353-q2k2krnm	861	62	favoring	favor	VBG
cord-022353-q2k2krnm	861	63	TH1	TH1	NNP
cord-022353-q2k2krnm	861	64	immune	immune	JJ
cord-022353-q2k2krnm	861	65	polarization	polarization	NN
cord-022353-q2k2krnm	861	66	(	(	-LRB-
cord-022353-q2k2krnm	861	67	Moser	Moser	NNP
cord-022353-q2k2krnm	861	68	et	et	NNP
cord-022353-q2k2krnm	861	69	al	al	NNP
cord-022353-q2k2krnm	861	70	.	.	.
cord-022353-q2k2krnm	861	71	2004	2004	CD
cord-022353-q2k2krnm	861	72	)	)	-RRB-
cord-022353-q2k2krnm	861	73	.	.	.
cord-022353-q2k2krnm	862	1	Table	table	NN
cord-022353-q2k2krnm	862	2	6	6	CD
cord-022353-q2k2krnm	862	3	-10	-10	NN
cord-022353-q2k2krnm	862	4	summarizes	summarize	VBZ
cord-022353-q2k2krnm	862	5	some	some	DT
cord-022353-q2k2krnm	862	6	known	know	VBN
cord-022353-q2k2krnm	862	7	effects	effect	NNS
cord-022353-q2k2krnm	862	8	of	of	IN
cord-022353-q2k2krnm	862	9	murine	murine	JJ
cord-022353-q2k2krnm	862	10	chemokines	chemokine	NNS
cord-022353-q2k2krnm	862	11	.	.	.
cord-022353-q2k2krnm	863	1	Because	because	IN
cord-022353-q2k2krnm	863	2	chemokines	chemokine	NNS
cord-022353-q2k2krnm	863	3	and	and	CC
cord-022353-q2k2krnm	863	4	their	-PRON-	PRP$
cord-022353-q2k2krnm	863	5	receptors	receptor	NNS
cord-022353-q2k2krnm	863	6	are	be	VBP
cord-022353-q2k2krnm	863	7	known	know	VBN
cord-022353-q2k2krnm	863	8	to	to	TO
cord-022353-q2k2krnm	863	9	modulate	modulate	VB
cord-022353-q2k2krnm	863	10	many	many	JJ
cord-022353-q2k2krnm	863	11	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	863	12	diseases	disease	NNS
cord-022353-q2k2krnm	863	13	including	include	VBG
cord-022353-q2k2krnm	863	14	the	the	DT
cord-022353-q2k2krnm	863	15	autoimmune	autoimmune	JJ
cord-022353-q2k2krnm	863	16	diseases	disease	NNS
cord-022353-q2k2krnm	863	17	,	,	,
cord-022353-q2k2krnm	863	18	they	-PRON-	PRP
cord-022353-q2k2krnm	863	19	have	have	VBP
cord-022353-q2k2krnm	863	20	become	become	VBN
cord-022353-q2k2krnm	863	21	target	target	NN
cord-022353-q2k2krnm	863	22	for	for	IN
cord-022353-q2k2krnm	863	23	new	new	JJ
cord-022353-q2k2krnm	863	24	therapeutics	therapeutic	NNS
cord-022353-q2k2krnm	863	25	.	.	.
cord-022353-q2k2krnm	864	1	The	the	DT
cord-022353-q2k2krnm	864	2	chemokine	chemokine	NN
cord-022353-q2k2krnm	864	3	antagonist	antagonist	NN
cord-022353-q2k2krnm	864	4	,	,	,
cord-022353-q2k2krnm	864	5	Met	Met	NNP
cord-022353-q2k2krnm	864	6	-	-	HYPH
cord-022353-q2k2krnm	864	7	RANTES	RANTES	NNP
cord-022353-q2k2krnm	864	8	,	,	,
cord-022353-q2k2krnm	864	9	has	have	VBZ
cord-022353-q2k2krnm	864	10	been	be	VBN
cord-022353-q2k2krnm	864	11	shown	show	VBN
cord-022353-q2k2krnm	864	12	to	to	TO
cord-022353-q2k2krnm	864	13	be	be	VB
cord-022353-q2k2krnm	864	14	an	an	DT
cord-022353-q2k2krnm	864	15	effective	effective	JJ
cord-022353-q2k2krnm	864	16	inhibitor	inhibitor	NN
cord-022353-q2k2krnm	864	17	of	of	IN
cord-022353-q2k2krnm	864	18	allergic	allergic	JJ
cord-022353-q2k2krnm	864	19	airway	airway	NN
cord-022353-q2k2krnm	864	20	disease	disease	NN
cord-022353-q2k2krnm	864	21	in	in	IN
cord-022353-q2k2krnm	864	22	mice	mouse	NNS
cord-022353-q2k2krnm	864	23	.	.	.
cord-022353-q2k2krnm	865	1	Likewise	likewise	RB
cord-022353-q2k2krnm	865	2	,	,	,
cord-022353-q2k2krnm	865	3	deficiencies	deficiency	NNS
cord-022353-q2k2krnm	865	4	of	of	IN
cord-022353-q2k2krnm	865	5	chemokines	chemokine	NNS
cord-022353-q2k2krnm	865	6	and	and	CC
cord-022353-q2k2krnm	865	7	their	-PRON-	PRP$
cord-022353-q2k2krnm	865	8	receptors	receptor	NNS
cord-022353-q2k2krnm	865	9	in	in	IN
cord-022353-q2k2krnm	865	10	mice	mouse	NNS
cord-022353-q2k2krnm	865	11	have	have	VBP
cord-022353-q2k2krnm	865	12	modified	modify	VBN
cord-022353-q2k2krnm	865	13	disease	disease	NN
cord-022353-q2k2krnm	865	14	progression	progression	NN
cord-022353-q2k2krnm	865	15	in	in	IN
cord-022353-q2k2krnm	865	16	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	865	17	,	,	,
cord-022353-q2k2krnm	865	18	autoimmunity	autoimmunity	NN
cord-022353-q2k2krnm	865	19	,	,	,
cord-022353-q2k2krnm	865	20	and	and	CC
cord-022353-q2k2krnm	865	21	also	also	RB
cord-022353-q2k2krnm	865	22	prolong	prolong	VB
cord-022353-q2k2krnm	865	23	allograft	allograft	NN
cord-022353-q2k2krnm	865	24	survival	survival	NN
cord-022353-q2k2krnm	865	25	(	(	-LRB-
cord-022353-q2k2krnm	865	26	Mackay	Mackay	NNP
cord-022353-q2k2krnm	865	27	2001	2001	CD
cord-022353-q2k2krnm	865	28	)	)	-RRB-
cord-022353-q2k2krnm	865	29	.	.	.
cord-022353-q2k2krnm	866	1	In	in	IN
cord-022353-q2k2krnm	866	2	addition	addition	NN
cord-022353-q2k2krnm	866	3	,	,	,
cord-022353-q2k2krnm	866	4	many	many	JJ
cord-022353-q2k2krnm	866	5	viral	viral	JJ
cord-022353-q2k2krnm	866	6	genomes	genome	NNS
cord-022353-q2k2krnm	866	7	are	be	VBP
cord-022353-q2k2krnm	866	8	known	know	VBN
cord-022353-q2k2krnm	866	9	to	to	TO
cord-022353-q2k2krnm	866	10	encode	encode	VB
cord-022353-q2k2krnm	866	11	structural	structural	JJ
cord-022353-q2k2krnm	866	12	genes	gene	NNS
cord-022353-q2k2krnm	866	13	for	for	IN
cord-022353-q2k2krnm	866	14	chemokine	chemokine	NN
cord-022353-q2k2krnm	866	15	antagonists	antagonist	NNS
cord-022353-q2k2krnm	866	16	,	,	,
cord-022353-q2k2krnm	866	17	which	which	WDT
cord-022353-q2k2krnm	866	18	appears	appear	VBZ
cord-022353-q2k2krnm	866	19	to	to	TO
cord-022353-q2k2krnm	866	20	be	be	VB
cord-022353-q2k2krnm	866	21	a	a	DT
cord-022353-q2k2krnm	866	22	principal	principal	JJ
cord-022353-q2k2krnm	866	23	mechanism	mechanism	NN
cord-022353-q2k2krnm	866	24	used	use	VBN
cord-022353-q2k2krnm	866	25	by	by	IN
cord-022353-q2k2krnm	866	26	many	many	JJ
cord-022353-q2k2krnm	866	27	viruses	virus	NNS
cord-022353-q2k2krnm	866	28	to	to	TO
cord-022353-q2k2krnm	866	29	evade	evade	VB
cord-022353-q2k2krnm	866	30	the	the	DT
cord-022353-q2k2krnm	866	31	host	host	NN
cord-022353-q2k2krnm	866	32	immune	immune	JJ
cord-022353-q2k2krnm	866	33	system	system	NN
cord-022353-q2k2krnm	866	34	.	.	.
cord-022353-q2k2krnm	867	1	These	these	DT
cord-022353-q2k2krnm	867	2	present	present	VBP
cord-022353-q2k2krnm	867	3	another	another	DT
cord-022353-q2k2krnm	867	4	target	target	NN
cord-022353-q2k2krnm	867	5	for	for	IN
cord-022353-q2k2krnm	867	6	drug	drug	NN
cord-022353-q2k2krnm	867	7	intervention	intervention	NN
cord-022353-q2k2krnm	867	8	for	for	IN
cord-022353-q2k2krnm	867	9	viral	viral	JJ
cord-022353-q2k2krnm	867	10	infections	infection	NNS
cord-022353-q2k2krnm	867	11	.	.	.
cord-022353-q2k2krnm	868	1	Finally	finally	RB
cord-022353-q2k2krnm	868	2	,	,	,
cord-022353-q2k2krnm	868	3	pepducins	pepducins	NNP
cord-022353-q2k2krnm	868	4	,	,	,
cord-022353-q2k2krnm	868	5	derived	derive	VBN
cord-022353-q2k2krnm	868	6	from	from	IN
cord-022353-q2k2krnm	868	7	the	the	DT
cord-022353-q2k2krnm	868	8	intracellular	intracellular	JJ
cord-022353-q2k2krnm	868	9	loops	loop	NNS
cord-022353-q2k2krnm	868	10	of	of	IN
cord-022353-q2k2krnm	868	11	CXCR1	cxcr1	NN
cord-022353-q2k2krnm	868	12	,	,	,
cord-022353-q2k2krnm	868	13	CXCR2	CXCR2	NNS
cord-022353-q2k2krnm	868	14	,	,	,
cord-022353-q2k2krnm	868	15	and	and	CC
cord-022353-q2k2krnm	868	16	CXCR4	CXCR4	NNS
cord-022353-q2k2krnm	868	17	,	,	,
cord-022353-q2k2krnm	868	18	specifically	specifically	RB
cord-022353-q2k2krnm	868	19	inhibit	inhibit	VB
cord-022353-q2k2krnm	868	20	receptor	receptor	NN
cord-022353-q2k2krnm	868	21	G	g	NN
cord-022353-q2k2krnm	868	22	-	-	HYPH
cord-022353-q2k2krnm	868	23	protein	protein	NN
cord-022353-q2k2krnm	868	24	signaling	signaling	NN
cord-022353-q2k2krnm	868	25	in	in	IN
cord-022353-q2k2krnm	868	26	mice	mouse	NNS
cord-022353-q2k2krnm	868	27	and	and	CC
cord-022353-q2k2krnm	868	28	prevent	prevent	VB
cord-022353-q2k2krnm	868	29	fatal	fatal	JJ
cord-022353-q2k2krnm	868	30	sepsis	sepsis	NN
cord-022353-q2k2krnm	868	31	and	and	CC
cord-022353-q2k2krnm	868	32	disseminated	disseminate	VBN
cord-022353-q2k2krnm	868	33	intravascular	intravascular	JJ
cord-022353-q2k2krnm	868	34	coagulation	coagulation	NN
cord-022353-q2k2krnm	869	1	(	(	-LRB-
cord-022353-q2k2krnm	869	2	Kaneider	Kaneider	NNP
cord-022353-q2k2krnm	869	3	et	et	NNP
cord-022353-q2k2krnm	869	4	al	al	NNP
cord-022353-q2k2krnm	869	5	.	.	NNP
cord-022353-q2k2krnm	869	6	2005	2005	CD
cord-022353-q2k2krnm	869	7	)	)	-RRB-
cord-022353-q2k2krnm	869	8	.	.	.
cord-022353-q2k2krnm	870	1	Certain	certain	JJ
cord-022353-q2k2krnm	870	2	growth	growth	NN
cord-022353-q2k2krnm	870	3	factors	factor	NNS
cord-022353-q2k2krnm	870	4	(	(	-LRB-
cord-022353-q2k2krnm	870	5	see	see	VB
cord-022353-q2k2krnm	870	6	Table	table	NN
cord-022353-q2k2krnm	870	7	6	6	CD
cord-022353-q2k2krnm	870	8	-3	-3	NNP
cord-022353-q2k2krnm	870	9	)	)	-RRB-
cord-022353-q2k2krnm	870	10	and	and	CC
cord-022353-q2k2krnm	870	11	cytokines	cytokine	NNS
cord-022353-q2k2krnm	870	12	activate	activate	VBP
cord-022353-q2k2krnm	870	13	phospholipases	phospholipase	NNS
cord-022353-q2k2krnm	870	14	after	after	IN
cord-022353-q2k2krnm	870	15	binding	bind	VBG
cord-022353-q2k2krnm	870	16	their	-PRON-	PRP$
cord-022353-q2k2krnm	870	17	cell	cell	NN
cord-022353-q2k2krnm	870	18	surface	surface	NN
cord-022353-q2k2krnm	870	19	receptors	receptor	NNS
cord-022353-q2k2krnm	870	20	.	.	.
cord-022353-q2k2krnm	871	1	These	these	DT
cord-022353-q2k2krnm	871	2	phospholipases	phospholipases	NNP
cord-022353-q2k2krnm	871	3	act	act	VBP
cord-022353-q2k2krnm	871	4	on	on	IN
cord-022353-q2k2krnm	871	5	membrane	membrane	NN
cord-022353-q2k2krnm	871	6	phospholipids	phospholipid	NNS
cord-022353-q2k2krnm	871	7	to	to	TO
cord-022353-q2k2krnm	871	8	release	release	VB
cord-022353-q2k2krnm	871	9	arachidonic	arachidonic	JJ
cord-022353-q2k2krnm	871	10	acid	acid	NN
cord-022353-q2k2krnm	871	11	,	,	,
cord-022353-q2k2krnm	871	12	a	a	DT
cord-022353-q2k2krnm	871	13	precursor	precursor	NN
cord-022353-q2k2krnm	871	14	for	for	IN
cord-022353-q2k2krnm	871	15	several	several	JJ
cord-022353-q2k2krnm	871	16	eicosanoids	eicosanoid	NNS
cord-022353-q2k2krnm	871	17	.	.	.
cord-022353-q2k2krnm	872	1	Arachidonic	arachidonic	JJ
cord-022353-q2k2krnm	872	2	acid	acid	NN
cord-022353-q2k2krnm	872	3	is	be	VBZ
cord-022353-q2k2krnm	872	4	metabolized	metabolize	VBN
cord-022353-q2k2krnm	872	5	by	by	IN
cord-022353-q2k2krnm	872	6	any	any	DT
cord-022353-q2k2krnm	872	7	one	one	CD
cord-022353-q2k2krnm	872	8	of	of	IN
cord-022353-q2k2krnm	872	9	three	three	CD
cord-022353-q2k2krnm	872	10	biochemical	biochemical	JJ
cord-022353-q2k2krnm	872	11	pathways	pathway	NNS
cord-022353-q2k2krnm	872	12	:	:	:
cord-022353-q2k2krnm	872	13	the	the	DT
cord-022353-q2k2krnm	872	14	cyclooxygenase	cyclooxygenase	NN
cord-022353-q2k2krnm	872	15	(	(	-LRB-
cord-022353-q2k2krnm	872	16	COX	COX	NNP
cord-022353-q2k2krnm	872	17	)	)	-RRB-
cord-022353-q2k2krnm	872	18	pathway	pathway	NN
cord-022353-q2k2krnm	872	19	,	,	,
cord-022353-q2k2krnm	872	20	which	which	WDT
cord-022353-q2k2krnm	872	21	forms	form	VBZ
cord-022353-q2k2krnm	872	22	PGs	pg	NNS
cord-022353-q2k2krnm	872	23	and	and	CC
cord-022353-q2k2krnm	872	24	thromboxane	thromboxane	NN
cord-022353-q2k2krnm	872	25	,	,	,
cord-022353-q2k2krnm	872	26	the	the	DT
cord-022353-q2k2krnm	872	27	LO	LO	NNP
cord-022353-q2k2krnm	872	28	pathway	pathway	NN
cord-022353-q2k2krnm	872	29	,	,	,
cord-022353-q2k2krnm	872	30	which	which	WDT
cord-022353-q2k2krnm	872	31	forms	form	VBZ
cord-022353-q2k2krnm	872	32	HETEs	hete	NNS
cord-022353-q2k2krnm	872	33	and	and	CC
cord-022353-q2k2krnm	872	34	leukotrienes	leukotriene	NNS
cord-022353-q2k2krnm	872	35	(	(	-LRB-
cord-022353-q2k2krnm	872	36	LTs	LTs	NNP
cord-022353-q2k2krnm	872	37	)	)	-RRB-
cord-022353-q2k2krnm	872	38	,	,	,
cord-022353-q2k2krnm	872	39	and	and	CC
cord-022353-q2k2krnm	872	40	the	the	DT
cord-022353-q2k2krnm	872	41	cytochrome	cytochrome	NN
cord-022353-q2k2krnm	872	42	P-450	P-450	VBD
cord-022353-q2k2krnm	872	43	monooxygenase	monooxygenase	NNP
cord-022353-q2k2krnm	872	44	pathway	pathway	NN
cord-022353-q2k2krnm	872	45	,	,	,
cord-022353-q2k2krnm	872	46	which	which	WDT
cord-022353-q2k2krnm	872	47	forms	form	VBZ
cord-022353-q2k2krnm	872	48	epoxides	epoxide	NNS
cord-022353-q2k2krnm	872	49	and	and	CC
cord-022353-q2k2krnm	872	50	HETEs	hete	NNS
cord-022353-q2k2krnm	872	51	.	.	.
cord-022353-q2k2krnm	873	1	The	the	DT
cord-022353-q2k2krnm	873	2	COX	COX	NNP
cord-022353-q2k2krnm	873	3	enzymes	enzyme	NNS
cord-022353-q2k2krnm	873	4	,	,	,
cord-022353-q2k2krnm	873	5	COX-1	cox-1	JJ
cord-022353-q2k2krnm	873	6	and	and	CC
cord-022353-q2k2krnm	873	7	COX-2	COX-2	NNP
cord-022353-q2k2krnm	873	8	,	,	,
cord-022353-q2k2krnm	873	9	catalyze	catalyze	VB
cord-022353-q2k2krnm	873	10	the	the	DT
cord-022353-q2k2krnm	873	11	first	first	JJ
cord-022353-q2k2krnm	873	12	step	step	NN
cord-022353-q2k2krnm	873	13	in	in	IN
cord-022353-q2k2krnm	873	14	the	the	DT
cord-022353-q2k2krnm	873	15	synthesis	synthesis	NN
cord-022353-q2k2krnm	873	16	of	of	IN
cord-022353-q2k2krnm	873	17	PGs	pg	NNS
cord-022353-q2k2krnm	873	18	by	by	IN
cord-022353-q2k2krnm	873	19	converting	convert	VBG
cord-022353-q2k2krnm	873	20	arachidonic	arachidonic	JJ
cord-022353-q2k2krnm	873	21	acid	acid	NN
cord-022353-q2k2krnm	873	22	to	to	IN
cord-022353-q2k2krnm	873	23	prostaglandin	prostaglandin	NN
cord-022353-q2k2krnm	873	24	H	h	NN
cord-022353-q2k2krnm	873	25	2	2	CD
cord-022353-q2k2krnm	873	26	(	(	-LRB-
cord-022353-q2k2krnm	873	27	PGH2	PGH2	NNP
cord-022353-q2k2krnm	873	28	)	)	-RRB-
cord-022353-q2k2krnm	873	29	.	.	.
cord-022353-q2k2krnm	874	1	PGH	PGH	NNP
cord-022353-q2k2krnm	874	2	2	2	CD
cord-022353-q2k2krnm	874	3	is	be	VBZ
cord-022353-q2k2krnm	874	4	chemically	chemically	RB
cord-022353-q2k2krnm	874	5	unstable	unstable	JJ
cord-022353-q2k2krnm	874	6	and	and	CC
cord-022353-q2k2krnm	874	7	is	be	VBZ
cord-022353-q2k2krnm	874	8	the	the	DT
cord-022353-q2k2krnm	874	9	precursor	precursor	NN
cord-022353-q2k2krnm	874	10	for	for	IN
cord-022353-q2k2krnm	874	11	enzymatic	enzymatic	JJ
cord-022353-q2k2krnm	874	12	and	and	CC
cord-022353-q2k2krnm	874	13	nonenzymatic	nonenzymatic	JJ
cord-022353-q2k2krnm	874	14	production	production	NN
cord-022353-q2k2krnm	874	15	of	of	IN
cord-022353-q2k2krnm	874	16	PGD	PGD	NNP
cord-022353-q2k2krnm	874	17	2	2	CD
cord-022353-q2k2krnm	874	18	,	,	,
cord-022353-q2k2krnm	874	19	PGE	PGE	NNP
cord-022353-q2k2krnm	874	20	2	2	CD
cord-022353-q2k2krnm	874	21	,	,	,
cord-022353-q2k2krnm	874	22	and	and	CC
cord-022353-q2k2krnm	874	23	PGFza	PGFza	NNS
cord-022353-q2k2krnm	874	24	.	.	.
cord-022353-q2k2krnm	875	1	Thromboxane	Thromboxane	NNP
cord-022353-q2k2krnm	875	2	synthetase	synthetase	NN
cord-022353-q2k2krnm	875	3	converts	convert	VBZ
cord-022353-q2k2krnm	875	4	PGH	PGH	NNP
cord-022353-q2k2krnm	875	5	2	2	CD
cord-022353-q2k2krnm	875	6	to	to	IN
cord-022353-q2k2krnm	875	7	thromboxane	thromboxane	NN
cord-022353-q2k2krnm	875	8	A	a	DT
cord-022353-q2k2krnm	875	9	2	2	CD
cord-022353-q2k2krnm	875	10	(	(	-LRB-
cord-022353-q2k2krnm	875	11	TXA2	TXA2	NNP
cord-022353-q2k2krnm	875	12	)	)	-RRB-
cord-022353-q2k2krnm	875	13	that	that	WDT
cord-022353-q2k2krnm	875	14	is	be	VBZ
cord-022353-q2k2krnm	875	15	quickly	quickly	RB
cord-022353-q2k2krnm	875	16	converted	convert	VBN
cord-022353-q2k2krnm	875	17	to	to	IN
cord-022353-q2k2krnm	875	18	thromboxane	thromboxane	NN
cord-022353-q2k2krnm	875	19	B	b	NN
cord-022353-q2k2krnm	875	20	2	2	CD
cord-022353-q2k2krnm	875	21	(	(	-LRB-
cord-022353-q2k2krnm	875	22	TXB2	TXB2	NNP
cord-022353-q2k2krnm	875	23	)	)	-RRB-
cord-022353-q2k2krnm	875	24	.	.	.
cord-022353-q2k2krnm	876	1	In	in	IN
cord-022353-q2k2krnm	876	2	vascular	vascular	JJ
cord-022353-q2k2krnm	876	3	tissue	tissue	NN
cord-022353-q2k2krnm	876	4	,	,	,
cord-022353-q2k2krnm	876	5	PGH	PGH	NNP
cord-022353-q2k2krnm	876	6	2	2	CD
cord-022353-q2k2krnm	876	7	is	be	VBZ
cord-022353-q2k2krnm	876	8	converted	convert	VBN
cord-022353-q2k2krnm	876	9	to	to	IN
cord-022353-q2k2krnm	876	10	PGI	PGI	NNP
cord-022353-q2k2krnm	876	11	2	2	CD
cord-022353-q2k2krnm	876	12	or	or	CC
cord-022353-q2k2krnm	876	13	prostacyclin	prostacyclin	NNP
cord-022353-q2k2krnm	876	14	by	by	IN
cord-022353-q2k2krnm	876	15	prostacyclin	prostacyclin	NNP
cord-022353-q2k2krnm	876	16	synthetase	synthetase	NNP
cord-022353-q2k2krnm	876	17	(	(	-LRB-
cord-022353-q2k2krnm	876	18	Natarajan	Natarajan	NNP
cord-022353-q2k2krnm	876	19	and	and	CC
cord-022353-q2k2krnm	876	20	Nadler	Nadler	NNP
cord-022353-q2k2krnm	876	21	2004	2004	CD
cord-022353-q2k2krnm	876	22	;	;	:
cord-022353-q2k2krnm	876	23	Reimers	Reimers	NNPS
cord-022353-q2k2krnm	876	24	1999	1999	CD
cord-022353-q2k2krnm	876	25	)	)	-RRB-
cord-022353-q2k2krnm	876	26	.	.	.
cord-022353-q2k2krnm	877	1	Although	although	IN
cord-022353-q2k2krnm	877	2	COX-1	COX-1	NNP
cord-022353-q2k2krnm	877	3	is	be	VBZ
cord-022353-q2k2krnm	877	4	constitutively	constitutively	RB
cord-022353-q2k2krnm	877	5	expressed	express	VBN
cord-022353-q2k2krnm	877	6	in	in	IN
cord-022353-q2k2krnm	877	7	most	most	JJS
cord-022353-q2k2krnm	877	8	tissues	tissue	NNS
cord-022353-q2k2krnm	877	9	,	,	,
cord-022353-q2k2krnm	877	10	COX-2	COX-2	NNP
cord-022353-q2k2krnm	877	11	is	be	VBZ
cord-022353-q2k2krnm	877	12	induced	induce	VBN
cord-022353-q2k2krnm	877	13	by	by	IN
cord-022353-q2k2krnm	877	14	bacterial	bacterial	JJ
cord-022353-q2k2krnm	877	15	lipopolysaccharides	lipopolysaccharide	NNS
cord-022353-q2k2krnm	877	16	,	,	,
cord-022353-q2k2krnm	877	17	IL	IL	NNP
cord-022353-q2k2krnm	877	18	-	-	HYPH
cord-022353-q2k2krnm	877	19	I~	I~	NNP
cord-022353-q2k2krnm	877	20	,	,	,
cord-022353-q2k2krnm	877	21	IL	IL	NNP
cord-022353-q2k2krnm	877	22	-	-	HYPH
cord-022353-q2k2krnm	877	23	ll~	ll~	NNP
cord-022353-q2k2krnm	877	24	,	,	,
cord-022353-q2k2krnm	877	25	and	and	CC
cord-022353-q2k2krnm	877	26	TNF-~	TNF-~	NNP
cord-022353-q2k2krnm	877	27	(	(	-LRB-
cord-022353-q2k2krnm	877	28	see	see	VB
cord-022353-q2k2krnm	877	29	the	the	DT
cord-022353-q2k2krnm	877	30	"	"	``
cord-022353-q2k2krnm	877	31	Cytokines	Cytokines	NNPS
cord-022353-q2k2krnm	877	32	and	and	CC
cord-022353-q2k2krnm	877	33	Chemokines	Chemokines	NNPS
cord-022353-q2k2krnm	877	34	"	"	''
cord-022353-q2k2krnm	877	35	section	section	NN
cord-022353-q2k2krnm	877	36	)	)	-RRB-
cord-022353-q2k2krnm	877	37	.	.	.
cord-022353-q2k2krnm	878	1	In	in	IN
cord-022353-q2k2krnm	878	2	the	the	DT
cord-022353-q2k2krnm	878	3	circulation	circulation	NN
cord-022353-q2k2krnm	878	4	,	,	,
cord-022353-q2k2krnm	878	5	PGE	PGE	NNP
cord-022353-q2k2krnm	878	6	2	2	CD
cord-022353-q2k2krnm	878	7	and	and	CC
cord-022353-q2k2krnm	878	8	PGI	PGI	NNP
cord-022353-q2k2krnm	878	9	2	2	CD
cord-022353-q2k2krnm	878	10	cause	cause	NN
cord-022353-q2k2krnm	878	11	vasodilation	vasodilation	NN
cord-022353-q2k2krnm	878	12	,	,	,
cord-022353-q2k2krnm	878	13	whereas	whereas	IN
cord-022353-q2k2krnm	878	14	PGFza	PGFza	NNP
cord-022353-q2k2krnm	878	15	and	and	CC
cord-022353-q2k2krnm	878	16	TXB	TXB	NNP
cord-022353-q2k2krnm	878	17	2	2	CD
cord-022353-q2k2krnm	878	18	are	be	VBP
cord-022353-q2k2krnm	878	19	potent	potent	JJ
cord-022353-q2k2krnm	878	20	vasoconstrictors	vasoconstrictor	NNS
cord-022353-q2k2krnm	878	21	.	.	.
cord-022353-q2k2krnm	879	1	In	in	IN
cord-022353-q2k2krnm	879	2	the	the	DT
cord-022353-q2k2krnm	879	3	kidney	kidney	NN
cord-022353-q2k2krnm	879	4	,	,	,
cord-022353-q2k2krnm	879	5	PGE1	PGE1	NNP
cord-022353-q2k2krnm	879	6	,	,	,
cord-022353-q2k2krnm	879	7	PGE2	PGE2	NNP
cord-022353-q2k2krnm	879	8	,	,	,
cord-022353-q2k2krnm	879	9	PGD2	PGD2	NNP
cord-022353-q2k2krnm	879	10	,	,	,
cord-022353-q2k2krnm	879	11	PGG2	PGG2	NNP
cord-022353-q2k2krnm	879	12	,	,	,
cord-022353-q2k2krnm	879	13	PGI2	PGI2	NNP
cord-022353-q2k2krnm	879	14	,	,	,
cord-022353-q2k2krnm	879	15	and	and	CC
cord-022353-q2k2krnm	879	16	PGH2	PGH2	NNP
cord-022353-q2k2krnm	879	17	produce	produce	VBP
cord-022353-q2k2krnm	879	18	vasodilation	vasodilation	NN
cord-022353-q2k2krnm	879	19	,	,	,
cord-022353-q2k2krnm	879	20	increased	increase	VBN
cord-022353-q2k2krnm	879	21	renal	renal	JJ
cord-022353-q2k2krnm	879	22	blood	blood	NN
cord-022353-q2k2krnm	879	23	flow	flow	NN
cord-022353-q2k2krnm	879	24	,	,	,
cord-022353-q2k2krnm	879	25	and	and	CC
cord-022353-q2k2krnm	879	26	urinary	urinary	JJ
cord-022353-q2k2krnm	879	27	excretion	excretion	NN
cord-022353-q2k2krnm	879	28	of	of	IN
cord-022353-q2k2krnm	879	29	sodium	sodium	NN
cord-022353-q2k2krnm	879	30	.	.	.
cord-022353-q2k2krnm	880	1	Renal	renal	JJ
cord-022353-q2k2krnm	880	2	production	production	NN
cord-022353-q2k2krnm	880	3	is	be	VBZ
cord-022353-q2k2krnm	880	4	increased	increase	VBN
cord-022353-q2k2krnm	880	5	by	by	IN
cord-022353-q2k2krnm	880	6	PGD2	PGD2	NNP
cord-022353-q2k2krnm	880	7	,	,	,
cord-022353-q2k2krnm	880	8	PGE2	PGE2	NNP
cord-022353-q2k2krnm	880	9	,	,	,
cord-022353-q2k2krnm	880	10	and	and	CC
cord-022353-q2k2krnm	880	11	PGI2	PGI2	NNP
cord-022353-q2k2krnm	880	12	.	.	.
cord-022353-q2k2krnm	881	1	PGG2	PGG2	NNP
cord-022353-q2k2krnm	881	2	,	,	,
cord-022353-q2k2krnm	881	3	PGH2	PGH2	NNP
cord-022353-q2k2krnm	881	4	,	,	,
cord-022353-q2k2krnm	881	5	and	and	CC
cord-022353-q2k2krnm	881	6	TXA	TXA	NNP
cord-022353-q2k2krnm	881	7	2	2	CD
cord-022353-q2k2krnm	881	8	modulate	modulate	VBP
cord-022353-q2k2krnm	881	9	platelet	platelet	NN
cord-022353-q2k2krnm	881	10	aggregation	aggregation	NN
cord-022353-q2k2krnm	881	11	and	and	CC
cord-022353-q2k2krnm	881	12	,	,	,
cord-022353-q2k2krnm	881	13	following	follow	VBG
cord-022353-q2k2krnm	881	14	platelet	platelet	NN
cord-022353-q2k2krnm	881	15	adhesion	adhesion	NN
cord-022353-q2k2krnm	881	16	,	,	,
cord-022353-q2k2krnm	881	17	they	-PRON-	PRP
cord-022353-q2k2krnm	881	18	release	release	VBP
cord-022353-q2k2krnm	881	19	catecholamines	catecholamine	NNS
cord-022353-q2k2krnm	881	20	,	,	,
cord-022353-q2k2krnm	881	21	serotonin	serotonin	NN
cord-022353-q2k2krnm	881	22	,	,	,
cord-022353-q2k2krnm	881	23	and	and	CC
cord-022353-q2k2krnm	881	24	adenosine	adenosine	NN
cord-022353-q2k2krnm	881	25	diphosphate	diphosphate	NN
cord-022353-q2k2krnm	881	26	,	,	,
cord-022353-q2k2krnm	881	27	which	which	WDT
cord-022353-q2k2krnm	881	28	enhance	enhance	VBP
cord-022353-q2k2krnm	881	29	platelet	platelet	NN
cord-022353-q2k2krnm	881	30	aggregation	aggregation	NN
cord-022353-q2k2krnm	881	31	.	.	.
cord-022353-q2k2krnm	882	1	PGI	PGI	NNP
cord-022353-q2k2krnm	882	2	2	2	CD
cord-022353-q2k2krnm	882	3	is	be	VBZ
cord-022353-q2k2krnm	882	4	a	a	DT
cord-022353-q2k2krnm	882	5	potent	potent	JJ
cord-022353-q2k2krnm	882	6	inhibitor	inhibitor	NN
cord-022353-q2k2krnm	882	7	of	of	IN
cord-022353-q2k2krnm	882	8	platelet	platelet	NN
cord-022353-q2k2krnm	882	9	aggregation	aggregation	NN
cord-022353-q2k2krnm	882	10	.	.	.
cord-022353-q2k2krnm	883	1	PGE1	PGE1	NNP
cord-022353-q2k2krnm	883	2	increases	increase	NNS
cord-022353-q2k2krnm	883	3	,	,	,
cord-022353-q2k2krnm	883	4	whereas	whereas	IN
cord-022353-q2k2krnm	883	5	PGE2	PGE2	NNP
cord-022353-q2k2krnm	883	6	decreases	decrease	VBZ
cord-022353-q2k2krnm	883	7	,	,	,
cord-022353-q2k2krnm	883	8	the	the	DT
cord-022353-q2k2krnm	883	9	ability	ability	NN
cord-022353-q2k2krnm	883	10	of	of	IN
cord-022353-q2k2krnm	883	11	red	red	JJ
cord-022353-q2k2krnm	883	12	cells	cell	NNS
cord-022353-q2k2krnm	883	13	to	to	TO
cord-022353-q2k2krnm	883	14	pass	pass	VB
cord-022353-q2k2krnm	883	15	through	through	IN
cord-022353-q2k2krnm	883	16	capillaries	capillary	NNS
cord-022353-q2k2krnm	883	17	.	.	.
cord-022353-q2k2krnm	884	1	PGE2	PGE2	NNP
cord-022353-q2k2krnm	884	2	and	and	CC
cord-022353-q2k2krnm	884	3	PGFza	PGFza	NNP
cord-022353-q2k2krnm	884	4	inhibit	inhibit	VB
cord-022353-q2k2krnm	884	5	the	the	DT
cord-022353-q2k2krnm	884	6	activities	activity	NNS
cord-022353-q2k2krnm	884	7	of	of	IN
cord-022353-q2k2krnm	884	8	T	T	NNP
cord-022353-q2k2krnm	884	9	and	and	CC
cord-022353-q2k2krnm	884	10	B	B	NNP
cord-022353-q2k2krnm	884	11	cells	cell	NNS
cord-022353-q2k2krnm	884	12	and	and	CC
cord-022353-q2k2krnm	884	13	the	the	DT
cord-022353-q2k2krnm	884	14	production	production	NN
cord-022353-q2k2krnm	884	15	of	of	IN
cord-022353-q2k2krnm	884	16	ILs	il	NNS
cord-022353-q2k2krnm	884	17	and	and	CC
cord-022353-q2k2krnm	884	18	chemokines	chemokine	NNS
cord-022353-q2k2krnm	884	19	,	,	,
cord-022353-q2k2krnm	884	20	which	which	WDT
cord-022353-q2k2krnm	884	21	attract	attract	VBP
cord-022353-q2k2krnm	884	22	monocytes	monocyte	NNS
cord-022353-q2k2krnm	884	23	.	.	.
cord-022353-q2k2krnm	885	1	PGD	PGD	NNP
cord-022353-q2k2krnm	885	2	2	2	CD
cord-022353-q2k2krnm	885	3	is	be	VBZ
cord-022353-q2k2krnm	885	4	a	a	DT
cord-022353-q2k2krnm	885	5	potent	potent	JJ
cord-022353-q2k2krnm	885	6	inducer	inducer	NN
cord-022353-q2k2krnm	885	7	of	of	IN
cord-022353-q2k2krnm	885	8	chemotaxis	chemotaxis	NN
cord-022353-q2k2krnm	885	9	for	for	IN
cord-022353-q2k2krnm	885	10	TH	TH	NNP
cord-022353-q2k2krnm	885	11	2	2	CD
cord-022353-q2k2krnm	885	12	cells	cell	NNS
cord-022353-q2k2krnm	885	13	and	and	CC
cord-022353-q2k2krnm	885	14	plays	play	VBZ
cord-022353-q2k2krnm	885	15	a	a	DT
cord-022353-q2k2krnm	885	16	major	major	JJ
cord-022353-q2k2krnm	885	17	role	role	NN
cord-022353-q2k2krnm	885	18	in	in	IN
cord-022353-q2k2krnm	885	19	allergic	allergic	JJ
cord-022353-q2k2krnm	885	20	airway	airway	NN
cord-022353-q2k2krnm	885	21	disease	disease	NN
cord-022353-q2k2krnm	885	22	.	.	.
cord-022353-q2k2krnm	886	1	Through	through	IN
cord-022353-q2k2krnm	886	2	the	the	DT
cord-022353-q2k2krnm	886	3	varied	varied	JJ
cord-022353-q2k2krnm	886	4	activities	activity	NNS
cord-022353-q2k2krnm	886	5	of	of	IN
cord-022353-q2k2krnm	886	6	vasodilation	vasodilation	NN
cord-022353-q2k2krnm	886	7	,	,	,
cord-022353-q2k2krnm	886	8	vascular	vascular	JJ
cord-022353-q2k2krnm	886	9	permeability	permeability	NN
cord-022353-q2k2krnm	886	10	,	,	,
cord-022353-q2k2krnm	886	11	and	and	CC
cord-022353-q2k2krnm	886	12	leukocyte	leukocyte	NN
cord-022353-q2k2krnm	886	13	migration	migration	NN
cord-022353-q2k2krnm	886	14	,	,	,
cord-022353-q2k2krnm	886	15	the	the	DT
cord-022353-q2k2krnm	886	16	PGs	pg	NNS
cord-022353-q2k2krnm	886	17	are	be	VBP
cord-022353-q2k2krnm	886	18	potent	potent	JJ
cord-022353-q2k2krnm	886	19	modulators	modulator	NNS
cord-022353-q2k2krnm	886	20	of	of	IN
cord-022353-q2k2krnm	886	21	inflammation	inflammation	NN
cord-022353-q2k2krnm	886	22	.	.	.
cord-022353-q2k2krnm	887	1	In	in	IN
cord-022353-q2k2krnm	887	2	addition	addition	NN
cord-022353-q2k2krnm	887	3	PGE1	PGE1	NNP
cord-022353-q2k2krnm	887	4	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	887	5	Mackay	Mackay	NNP
cord-022353-q2k2krnm	887	6	2001	2001	CD
cord-022353-q2k2krnm	887	7	Rossi	Rossi	NNP
cord-022353-q2k2krnm	887	8	et	et	NNP
cord-022353-q2k2krnm	887	9	al	al	NNP
cord-022353-q2k2krnm	887	10	.	.	.
cord-022353-q2k2krnm	888	1	1999	1999	CD
cord-022353-q2k2krnm	889	1	Niess	Niess	NNP
cord-022353-q2k2krnm	889	2	et	et	FW
cord-022353-q2k2krnm	889	3	al	al	NNP
cord-022353-q2k2krnm	889	4	.	.	.
cord-022353-q2k2krnm	890	1	2005	2005	CD
cord-022353-q2k2krnm	891	1	Mackay	Mackay	NNP
cord-022353-q2k2krnm	891	2	2001	2001	CD
cord-022353-q2k2krnm	891	3	Huang	Huang	NNP
cord-022353-q2k2krnm	891	4	and	and	CC
cord-022353-q2k2krnm	891	5	Xiang	Xiang	NNP
cord-022353-q2k2krnm	891	6	2004	2004	CD
cord-022353-q2k2krnm	891	7	Yamaguchi	Yamaguchi	NNP
cord-022353-q2k2krnm	891	8	et	et	NNP
cord-022353-q2k2krnm	891	9	al	al	NNP
cord-022353-q2k2krnm	891	10	.	.	.
cord-022353-q2k2krnm	892	1	2005	2005	CD
cord-022353-q2k2krnm	892	2	insulin	insulin	NN
cord-022353-q2k2krnm	892	3	secretion	secretion	NN
cord-022353-q2k2krnm	892	4	and	and	CC
cord-022353-q2k2krnm	892	5	release	release	NN
cord-022353-q2k2krnm	892	6	after	after	IN
cord-022353-q2k2krnm	892	7	glucose	glucose	NN
cord-022353-q2k2krnm	892	8	challenge	challenge	NN
cord-022353-q2k2krnm	892	9	(	(	-LRB-
cord-022353-q2k2krnm	892	10	see	see	VB
cord-022353-q2k2krnm	892	11	the	the	DT
cord-022353-q2k2krnm	892	12	"	"	``
cord-022353-q2k2krnm	892	13	Glucose	Glucose	NNP
cord-022353-q2k2krnm	892	14	and	and	CC
cord-022353-q2k2krnm	892	15	Carbohydrate	Carbohydrate	NNP
cord-022353-q2k2krnm	892	16	Metabolism	Metabolism	NNP
cord-022353-q2k2krnm	892	17	"	"	''
cord-022353-q2k2krnm	892	18	section	section	NN
cord-022353-q2k2krnm	892	19	)	)	-RRB-
cord-022353-q2k2krnm	892	20	,	,	.
cord-022353-q2k2krnm	893	1	and	and	CC
cord-022353-q2k2krnm	893	2	it	-PRON-	PRP
cord-022353-q2k2krnm	893	3	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	893	4	the	the	DT
cord-022353-q2k2krnm	893	5	lipolytic	lipolytic	JJ
cord-022353-q2k2krnm	893	6	effects	effect	NNS
cord-022353-q2k2krnm	893	7	of	of	IN
cord-022353-q2k2krnm	893	8	glucagons	glucagon	NNS
cord-022353-q2k2krnm	893	9	,	,	,
cord-022353-q2k2krnm	893	10	adrenocorticotropic	adrenocorticotropic	NNP
cord-022353-q2k2krnm	893	11	hormone	hormone	NN
cord-022353-q2k2krnm	893	12	,	,	,
cord-022353-q2k2krnm	893	13	and	and	CC
cord-022353-q2k2krnm	893	14	epinephrine	epinephrine	NN
cord-022353-q2k2krnm	893	15	(	(	-LRB-
cord-022353-q2k2krnm	893	16	see	see	VB
cord-022353-q2k2krnm	893	17	the	the	DT
cord-022353-q2k2krnm	893	18	Lipid	Lipid	NNP
cord-022353-q2k2krnm	893	19	Metabolism	Metabolism	NNP
cord-022353-q2k2krnm	893	20	section	section	NN
cord-022353-q2k2krnm	893	21	)	)	-RRB-
cord-022353-q2k2krnm	893	22	and	and	CC
cord-022353-q2k2krnm	893	23	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	893	24	the	the	DT
cord-022353-q2k2krnm	893	25	secretion	secretion	NN
cord-022353-q2k2krnm	893	26	of	of	IN
cord-022353-q2k2krnm	893	27	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	893	28	,	,	,
cord-022353-q2k2krnm	893	29	prolactin	prolactin	NN
cord-022353-q2k2krnm	893	30	(	(	-LRB-
cord-022353-q2k2krnm	893	31	PRL	PRL	NNP
cord-022353-q2k2krnm	893	32	)	)	-RRB-
cord-022353-q2k2krnm	893	33	,	,	,
cord-022353-q2k2krnm	893	34	GH	GH	NNP
cord-022353-q2k2krnm	893	35	,	,	,
cord-022353-q2k2krnm	893	36	thyroid	thyroid	JJ
cord-022353-q2k2krnm	893	37	stimulating	stimulate	VBG
cord-022353-q2k2krnm	893	38	hormone	hormone	NN
cord-022353-q2k2krnm	893	39	(	(	-LRB-
cord-022353-q2k2krnm	893	40	TSH	TSH	NNP
cord-022353-q2k2krnm	893	41	)	)	-RRB-
cord-022353-q2k2krnm	893	42	,	,	,
cord-022353-q2k2krnm	893	43	and	and	CC
cord-022353-q2k2krnm	893	44	LH	LH	NNP
cord-022353-q2k2krnm	893	45	.	.	.
cord-022353-q2k2krnm	894	1	In	in	IN
cord-022353-q2k2krnm	894	2	fact	fact	NN
cord-022353-q2k2krnm	894	3	,	,	,
cord-022353-q2k2krnm	894	4	PGs	pg	NNS
cord-022353-q2k2krnm	894	5	have	have	VBP
cord-022353-q2k2krnm	894	6	a	a	DT
cord-022353-q2k2krnm	894	7	multitude	multitude	NN
cord-022353-q2k2krnm	894	8	of	of	IN
cord-022353-q2k2krnm	894	9	effects	effect	NNS
cord-022353-q2k2krnm	894	10	associated	associate	VBN
cord-022353-q2k2krnm	894	11	with	with	IN
cord-022353-q2k2krnm	894	12	female	female	JJ
cord-022353-q2k2krnm	894	13	reproduction	reproduction	NN
cord-022353-q2k2krnm	894	14	(	(	-LRB-
cord-022353-q2k2krnm	894	15	Reimers	Reimers	NNPS
cord-022353-q2k2krnm	894	16	1999	1999	CD
cord-022353-q2k2krnm	894	17	Table	Table	NNP
cord-022353-q2k2krnm	894	18	 	 	_SP
cord-022353-q2k2krnm	894	19	6	6	CD
cord-022353-q2k2krnm	894	20	 	 	_SP
cord-022353-q2k2krnm	895	1	Under	under	IN
cord-022353-q2k2krnm	895	2	the	the	DT
cord-022353-q2k2krnm	895	3	action	action	NN
cord-022353-q2k2krnm	895	4	of	of	IN
cord-022353-q2k2krnm	895	5	5-LO	5-lo	CD
cord-022353-q2k2krnm	895	6	,	,	,
cord-022353-q2k2krnm	895	7	arachidonic	arachidonic	JJ
cord-022353-q2k2krnm	895	8	acid	acid	NN
cord-022353-q2k2krnm	895	9	is	be	VBZ
cord-022353-q2k2krnm	895	10	converted	convert	VBN
cord-022353-q2k2krnm	895	11	to	to	IN
cord-022353-q2k2krnm	895	12	5-hydroxyperoxyeicosatetraenoic	5-hydroxyperoxyeicosatetraenoic	CD
cord-022353-q2k2krnm	895	13	acid	acid	NN
cord-022353-q2k2krnm	895	14	(	(	-LRB-
cord-022353-q2k2krnm	895	15	5-HPETE	5-hpete	CD
cord-022353-q2k2krnm	895	16	)	)	-RRB-
cord-022353-q2k2krnm	895	17	and	and	CC
cord-022353-q2k2krnm	895	18	then	then	RB
cord-022353-q2k2krnm	895	19	leukotriene	leukotriene	NNP
cord-022353-q2k2krnm	895	20	A4	A4	NNP
cord-022353-q2k2krnm	895	21	(	(	-LRB-
cord-022353-q2k2krnm	895	22	LTA4	LTA4	NNP
cord-022353-q2k2krnm	895	23	)	)	-RRB-
cord-022353-q2k2krnm	895	24	,	,	,
cord-022353-q2k2krnm	895	25	which	which	WDT
cord-022353-q2k2krnm	895	26	is	be	VBZ
cord-022353-q2k2krnm	895	27	unstable	unstable	JJ
cord-022353-q2k2krnm	895	28	.	.	.
cord-022353-q2k2krnm	896	1	LTA4	LTA4	NNP
cord-022353-q2k2krnm	896	2	is	be	VBZ
cord-022353-q2k2krnm	896	3	metabolized	metabolize	VBN
cord-022353-q2k2krnm	896	4	to	to	IN
cord-022353-q2k2krnm	896	5	LTB4	LTB4	NNP
cord-022353-q2k2krnm	896	6	by	by	IN
cord-022353-q2k2krnm	896	7	LTA4	LTA4	NNP
cord-022353-q2k2krnm	896	8	hydrolase	hydrolase	NN
cord-022353-q2k2krnm	896	9	or	or	CC
cord-022353-q2k2krnm	896	10	to	to	IN
cord-022353-q2k2krnm	896	11	cysteinyl	cysteinyl	NNP
cord-022353-q2k2krnm	896	12	leukotrienes	leukotriene	NNS
cord-022353-q2k2krnm	896	13	(	(	-LRB-
cord-022353-q2k2krnm	896	14	LTC4	LTC4	NNP
cord-022353-q2k2krnm	896	15	,	,	,
cord-022353-q2k2krnm	896	16	LTD4H	ltd4h	NN
cord-022353-q2k2krnm	896	17	,	,	,
cord-022353-q2k2krnm	896	18	and	and	CC
cord-022353-q2k2krnm	896	19	LTC45	LTC45	NNP
cord-022353-q2k2krnm	896	20	)	)	-RRB-
cord-022353-q2k2krnm	896	21	by	by	IN
cord-022353-q2k2krnm	896	22	LTC4	LTC4	NNP
cord-022353-q2k2krnm	896	23	synthase	synthase	NN
cord-022353-q2k2krnm	896	24	.	.	.
cord-022353-q2k2krnm	897	1	5-LO	5-lo	CD
cord-022353-q2k2krnm	897	2	expression	expression	NN
cord-022353-q2k2krnm	897	3	is	be	VBZ
cord-022353-q2k2krnm	897	4	limited	limit	VBN
cord-022353-q2k2krnm	897	5	to	to	IN
cord-022353-q2k2krnm	897	6	neutrophils	neutrophil	NNS
cord-022353-q2k2krnm	897	7	,	,	,
cord-022353-q2k2krnm	897	8	eosinophils	eosinophil	NNS
cord-022353-q2k2krnm	897	9	,	,	,
cord-022353-q2k2krnm	897	10	monocytes	monocyte	NNS
cord-022353-q2k2krnm	897	11	,	,	,
cord-022353-q2k2krnm	897	12	and	and	CC
cord-022353-q2k2krnm	897	13	mast	mast	NN
cord-022353-q2k2krnm	897	14	cells	cell	NNS
cord-022353-q2k2krnm	897	15	;	;	:
cord-022353-q2k2krnm	897	16	however	however	RB
cord-022353-q2k2krnm	897	17	,	,	,
cord-022353-q2k2krnm	897	18	LTA4	LTA4	NNP
cord-022353-q2k2krnm	897	19	hydrolase	hydrolase	NN
cord-022353-q2k2krnm	897	20	is	be	VBZ
cord-022353-q2k2krnm	897	21	expressed	express	VBN
cord-022353-q2k2krnm	897	22	in	in	IN
cord-022353-q2k2krnm	897	23	erythrocytes	erythrocyte	NNS
cord-022353-q2k2krnm	897	24	,	,	,
cord-022353-q2k2krnm	897	25	T	t	NN
cord-022353-q2k2krnm	897	26	cells	cell	NNS
cord-022353-q2k2krnm	897	27	,	,	,
cord-022353-q2k2krnm	897	28	platelets	platelet	NNS
cord-022353-q2k2krnm	897	29	,	,	,
cord-022353-q2k2krnm	897	30	airway	airway	NN
cord-022353-q2k2krnm	897	31	and	and	CC
cord-022353-q2k2krnm	897	32	intestinal	intestinal	JJ
cord-022353-q2k2krnm	897	33	epithelial	epithelial	JJ
cord-022353-q2k2krnm	897	34	cells	cell	NNS
cord-022353-q2k2krnm	897	35	,	,	,
cord-022353-q2k2krnm	897	36	fibroblasts	fibroblast	NNS
cord-022353-q2k2krnm	897	37	,	,	,
cord-022353-q2k2krnm	897	38	heart	heart	NN
cord-022353-q2k2krnm	897	39	,	,	,
cord-022353-q2k2krnm	897	40	kidney	kidney	NN
cord-022353-q2k2krnm	897	41	,	,	,
cord-022353-q2k2krnm	897	42	and	and	CC
cord-022353-q2k2krnm	897	43	adrenal	adrenal	JJ
cord-022353-q2k2krnm	897	44	cortex	cortex	NNS
cord-022353-q2k2krnm	897	45	.	.	.
cord-022353-q2k2krnm	898	1	Because	because	IN
cord-022353-q2k2krnm	898	2	the	the	DT
cord-022353-q2k2krnm	898	3	latter	latter	JJ
cord-022353-q2k2krnm	898	4	cells	cell	NNS
cord-022353-q2k2krnm	898	5	and	and	CC
cord-022353-q2k2krnm	898	6	tissues	tissue	NNS
cord-022353-q2k2krnm	898	7	do	do	VBP
cord-022353-q2k2krnm	898	8	not	not	RB
cord-022353-q2k2krnm	898	9	express	express	VB
cord-022353-q2k2krnm	898	10	5-LO	5-lo	CD
cord-022353-q2k2krnm	898	11	,	,	,
cord-022353-q2k2krnm	898	12	LTA4	LTA4	NNP
cord-022353-q2k2krnm	898	13	must	must	MD
cord-022353-q2k2krnm	898	14	be	be	VB
cord-022353-q2k2krnm	898	15	delivered	deliver	VBN
cord-022353-q2k2krnm	898	16	to	to	IN
cord-022353-q2k2krnm	898	17	them	-PRON-	PRP
cord-022353-q2k2krnm	898	18	via	via	IN
cord-022353-q2k2krnm	898	19	myeloid	myeloid	NN
cord-022353-q2k2krnm	898	20	cells	cell	NNS
cord-022353-q2k2krnm	898	21	by	by	IN
cord-022353-q2k2krnm	898	22	a	a	DT
cord-022353-q2k2krnm	898	23	process	process	NN
cord-022353-q2k2krnm	898	24	known	know	VBN
cord-022353-q2k2krnm	898	25	as	as	IN
cord-022353-q2k2krnm	898	26	transcellular	transcellular	NNP
cord-022353-q2k2krnm	898	27	biosynthesis	biosynthesis	NN
cord-022353-q2k2krnm	898	28	(	(	-LRB-
cord-022353-q2k2krnm	898	29	Maclouf	Maclouf	NNP
cord-022353-q2k2krnm	898	30	1993	1993	CD
cord-022353-q2k2krnm	898	31	)	)	-RRB-
cord-022353-q2k2krnm	898	32	.	.	.
cord-022353-q2k2krnm	899	1	Receptors	receptor	NNS
cord-022353-q2k2krnm	899	2	for	for	IN
cord-022353-q2k2krnm	899	3	LTB4	LTB4	NNP
cord-022353-q2k2krnm	899	4	(	(	-LRB-
cord-022353-q2k2krnm	899	5	BLT1	BLT1	NNP
cord-022353-q2k2krnm	899	6	and	and	CC
cord-022353-q2k2krnm	899	7	BLT2	BLT2	NNP
cord-022353-q2k2krnm	899	8	)	)	-RRB-
cord-022353-q2k2krnm	899	9	have	have	VBP
cord-022353-q2k2krnm	899	10	been	be	VBN
cord-022353-q2k2krnm	899	11	identified	identify	VBN
cord-022353-q2k2krnm	899	12	and	and	CC
cord-022353-q2k2krnm	899	13	are	be	VBP
cord-022353-q2k2krnm	899	14	either	either	CC
cord-022353-q2k2krnm	899	15	widely	widely	RB
cord-022353-q2k2krnm	899	16	expressed	express	VBN
cord-022353-q2k2krnm	899	17	(	(	-LRB-
cord-022353-q2k2krnm	899	18	BLT2	BLT2	NNP
cord-022353-q2k2krnm	899	19	)	)	-RRB-
cord-022353-q2k2krnm	899	20	or	or	CC
cord-022353-q2k2krnm	899	21	are	be	VBP
cord-022353-q2k2krnm	899	22	confined	confine	VBN
cord-022353-q2k2krnm	899	23	to	to	IN
cord-022353-q2k2krnm	899	24	myeloid	myeloid	JJ
cord-022353-q2k2krnm	899	25	cells	cell	NNS
cord-022353-q2k2krnm	899	26	,	,	,
cord-022353-q2k2krnm	899	27	T	t	NN
cord-022353-q2k2krnm	899	28	cells	cell	NNS
cord-022353-q2k2krnm	899	29	,	,	,
cord-022353-q2k2krnm	899	30	and	and	CC
cord-022353-q2k2krnm	899	31	lung	lung	NN
cord-022353-q2k2krnm	899	32	cells	cell	NNS
cord-022353-q2k2krnm	899	33	(	(	-LRB-
cord-022353-q2k2krnm	899	34	BLT1	BLT1	NNP
cord-022353-q2k2krnm	899	35	)	)	-RRB-
cord-022353-q2k2krnm	899	36	.	.	.
cord-022353-q2k2krnm	900	1	In	in	IN
cord-022353-q2k2krnm	900	2	addition	addition	NN
cord-022353-q2k2krnm	900	3	to	to	IN
cord-022353-q2k2krnm	900	4	attracting	attract	VBG
cord-022353-q2k2krnm	900	5	myeloid	myeloid	JJ
cord-022353-q2k2krnm	900	6	cells	cell	NNS
cord-022353-q2k2krnm	900	7	to	to	IN
cord-022353-q2k2krnm	900	8	sites	site	NNS
cord-022353-q2k2krnm	900	9	of	of	IN
cord-022353-q2k2krnm	900	10	inflammation	inflammation	NN
cord-022353-q2k2krnm	900	11	,	,	,
cord-022353-q2k2krnm	900	12	LTB4	LTB4	NNP
cord-022353-q2k2krnm	900	13	is	be	VBZ
cord-022353-q2k2krnm	900	14	a	a	DT
cord-022353-q2k2krnm	900	15	potent	potent	JJ
cord-022353-q2k2krnm	900	16	inducer	inducer	NN
cord-022353-q2k2krnm	900	17	of	of	IN
cord-022353-q2k2krnm	900	18	TH1	TH1	NNP
cord-022353-q2k2krnm	900	19	and	and	CC
cord-022353-q2k2krnm	900	20	TH2	TH2	NNP
cord-022353-q2k2krnm	900	21	T	T	NNP
cord-022353-q2k2krnm	900	22	effector	effector	NN
cord-022353-q2k2krnm	900	23	cell	cell	NN
cord-022353-q2k2krnm	900	24	chemotaxis	chemotaxis	NN
cord-022353-q2k2krnm	900	25	(	(	-LRB-
cord-022353-q2k2krnm	900	26	as	as	RB
cord-022353-q2k2krnm	900	27	potent	potent	JJ
cord-022353-q2k2krnm	900	28	as	as	IN
cord-022353-q2k2krnm	900	29	CXCL12	CXCL12	NNP
cord-022353-q2k2krnm	900	30	in	in	IN
cord-022353-q2k2krnm	900	31	the	the	DT
cord-022353-q2k2krnm	900	32	mouse	mouse	NN
cord-022353-q2k2krnm	900	33	)	)	-RRB-
cord-022353-q2k2krnm	900	34	and	and	CC
cord-022353-q2k2krnm	900	35	CD8+T	cd8+t	JJ
cord-022353-q2k2krnm	900	36	-	-	HYPH
cord-022353-q2k2krnm	900	37	effector	effector	NN
cord-022353-q2k2krnm	900	38	cell	cell	NN
cord-022353-q2k2krnm	900	39	chemotaxis	chemotaxis	NN
cord-022353-q2k2krnm	900	40	(	(	-LRB-
cord-022353-q2k2krnm	900	41	as	as	RB
cord-022353-q2k2krnm	900	42	potent	potent	JJ
cord-022353-q2k2krnm	900	43	as	as	IN
cord-022353-q2k2krnm	900	44	RANTES	RANTES	NNP
cord-022353-q2k2krnm	900	45	)	)	-RRB-
cord-022353-q2k2krnm	900	46	.	.	.
cord-022353-q2k2krnm	901	1	Like	like	IN
cord-022353-q2k2krnm	901	2	PGD2	PGD2	NNP
cord-022353-q2k2krnm	901	3	,	,	,
cord-022353-q2k2krnm	901	4	LTB4	LTB4	NNP
cord-022353-q2k2krnm	901	5	plays	play	VBZ
cord-022353-q2k2krnm	901	6	a	a	DT
cord-022353-q2k2krnm	901	7	major	major	JJ
cord-022353-q2k2krnm	901	8	role	role	NN
cord-022353-q2k2krnm	901	9	in	in	IN
cord-022353-q2k2krnm	901	10	allergic	allergic	JJ
cord-022353-q2k2krnm	901	11	airway	airway	NN
cord-022353-q2k2krnm	901	12	disease	disease	NN
cord-022353-q2k2krnm	901	13	(	(	-LRB-
cord-022353-q2k2krnm	901	14	Luster	Luster	NNP
cord-022353-q2k2krnm	901	15	and	and	CC
cord-022353-q2k2krnm	901	16	Tager	Tager	NNP
cord-022353-q2k2krnm	901	17	2004	2004	CD
cord-022353-q2k2krnm	901	18	)	)	-RRB-
cord-022353-q2k2krnm	901	19	.	.	.
cord-022353-q2k2krnm	902	1	Additional	additional	JJ
cord-022353-q2k2krnm	902	2	information	information	NN
cord-022353-q2k2krnm	902	3	on	on	IN
cord-022353-q2k2krnm	902	4	murine	murine	JJ
cord-022353-q2k2krnm	902	5	prostanoids	prostanoid	NNS
cord-022353-q2k2krnm	902	6	and	and	CC
cord-022353-q2k2krnm	902	7	their	-PRON-	PRP$
cord-022353-q2k2krnm	902	8	receptors	receptor	NNS
cord-022353-q2k2krnm	902	9	is	be	VBZ
cord-022353-q2k2krnm	902	10	available	available	JJ
cord-022353-q2k2krnm	902	11	in	in	IN
cord-022353-q2k2krnm	902	12	recent	recent	JJ
cord-022353-q2k2krnm	902	13	reviews	review	NNS
cord-022353-q2k2krnm	902	14	(	(	-LRB-
cord-022353-q2k2krnm	902	15	Jala	Jala	NNP
cord-022353-q2k2krnm	902	16	and	and	CC
cord-022353-q2k2krnm	902	17	Haribabu	Haribabu	NNP
cord-022353-q2k2krnm	902	18	2004	2004	CD
cord-022353-q2k2krnm	902	19	;	;	:
cord-022353-q2k2krnm	902	20	Kobayashi	Kobayashi	NNP
cord-022353-q2k2krnm	902	21	and	and	CC
cord-022353-q2k2krnm	902	22	Narumiya	Narumiya	NNP
cord-022353-q2k2krnm	902	23	2002	2002	CD
cord-022353-q2k2krnm	902	24	)	)	-RRB-
cord-022353-q2k2krnm	902	25	.	.	.
cord-022353-q2k2krnm	903	1	All	all	PDT
cord-022353-q2k2krnm	903	2	the	the	DT
cord-022353-q2k2krnm	903	3	arachidonic	arachidonic	JJ
cord-022353-q2k2krnm	903	4	acid	acid	NN
cord-022353-q2k2krnm	903	5	metabolites	metabolite	NNS
cord-022353-q2k2krnm	903	6	discussed	discuss	VBN
cord-022353-q2k2krnm	903	7	in	in	IN
cord-022353-q2k2krnm	903	8	this	this	DT
cord-022353-q2k2krnm	903	9	section	section	NN
cord-022353-q2k2krnm	903	10	may	may	MD
cord-022353-q2k2krnm	903	11	be	be	VB
cord-022353-q2k2krnm	903	12	quantified	quantify	VBN
cord-022353-q2k2krnm	903	13	using	use	VBG
cord-022353-q2k2krnm	903	14	commercially	commercially	RB
cord-022353-q2k2krnm	903	15	available	available	JJ
cord-022353-q2k2krnm	903	16	ELISA	ELISA	NNP
cord-022353-q2k2krnm	903	17	kits	kit	NNS
cord-022353-q2k2krnm	903	18	(	(	-LRB-
cord-022353-q2k2krnm	903	19	see	see	VB
cord-022353-q2k2krnm	903	20	Table	table	NN
cord-022353-q2k2krnm	903	21	6	6	CD
cord-022353-q2k2krnm	903	22	-3	-3	NNP
cord-022353-q2k2krnm	903	23	)	)	-RRB-
cord-022353-q2k2krnm	903	24	.	.	.
cord-022353-q2k2krnm	904	1	E.	E.	NNP
cord-022353-q2k2krnm	904	2	Enzymes	Enzymes	NNP
cord-022353-q2k2krnm	904	3	AP	AP	NNP
cord-022353-q2k2krnm	904	4	is	be	VBZ
cord-022353-q2k2krnm	904	5	an	an	DT
cord-022353-q2k2krnm	904	6	inducible	inducible	JJ
cord-022353-q2k2krnm	904	7	enzyme	enzyme	NN
cord-022353-q2k2krnm	904	8	in	in	IN
cord-022353-q2k2krnm	904	9	which	which	WDT
cord-022353-q2k2krnm	904	10	serum	serum	NN
cord-022353-q2k2krnm	904	11	activity	activity	NN
cord-022353-q2k2krnm	904	12	is	be	VBZ
cord-022353-q2k2krnm	904	13	increased	increase	VBN
cord-022353-q2k2krnm	904	14	due	due	IN
cord-022353-q2k2krnm	904	15	to	to	IN
cord-022353-q2k2krnm	904	16	increased	increase	VBN
cord-022353-q2k2krnm	904	17	synthesis	synthesis	NN
cord-022353-q2k2krnm	904	18	.	.	.
cord-022353-q2k2krnm	905	1	The	the	DT
cord-022353-q2k2krnm	905	2	exact	exact	JJ
cord-022353-q2k2krnm	905	3	physiologic	physiologic	JJ
cord-022353-q2k2krnm	905	4	function	function	NN
cord-022353-q2k2krnm	905	5	of	of	IN
cord-022353-q2k2krnm	905	6	AP	AP	NNP
cord-022353-q2k2krnm	905	7	is	be	VBZ
cord-022353-q2k2krnm	905	8	not	not	RB
cord-022353-q2k2krnm	905	9	known	know	VBN
cord-022353-q2k2krnm	905	10	but	but	CC
cord-022353-q2k2krnm	905	11	is	be	VBZ
cord-022353-q2k2krnm	905	12	thought	think	VBN
cord-022353-q2k2krnm	905	13	to	to	TO
cord-022353-q2k2krnm	905	14	transport	transport	VB
cord-022353-q2k2krnm	905	15	metabolites	metabolite	NNS
cord-022353-q2k2krnm	905	16	across	across	IN
cord-022353-q2k2krnm	905	17	cell	cell	NN
cord-022353-q2k2krnm	905	18	membranes	membrane	NNS
cord-022353-q2k2krnm	905	19	.	.	.
cord-022353-q2k2krnm	906	1	Quantification	quantification	NN
cord-022353-q2k2krnm	906	2	of	of	IN
cord-022353-q2k2krnm	906	3	serum	serum	NN
cord-022353-q2k2krnm	906	4	AP	AP	NNP
cord-022353-q2k2krnm	906	5	is	be	VBZ
cord-022353-q2k2krnm	906	6	based	base	VBN
cord-022353-q2k2krnm	906	7	on	on	IN
cord-022353-q2k2krnm	906	8	a	a	DT
cord-022353-q2k2krnm	906	9	reaction	reaction	NN
cord-022353-q2k2krnm	906	10	between	between	IN
cord-022353-q2k2krnm	906	11	AP	AP	NNP
cord-022353-q2k2krnm	906	12	and	and	CC
cord-022353-q2k2krnm	906	13	a	a	DT
cord-022353-q2k2krnm	906	14	suitable	suitable	JJ
cord-022353-q2k2krnm	906	15	phosphorylated	phosphorylated	JJ
cord-022353-q2k2krnm	906	16	substrate	substrate	NN
cord-022353-q2k2krnm	906	17	that	that	WDT
cord-022353-q2k2krnm	906	18	is	be	VBZ
cord-022353-q2k2krnm	906	19	susceptible	susceptible	JJ
cord-022353-q2k2krnm	906	20	to	to	IN
cord-022353-q2k2krnm	906	21	AP	AP	NNP
cord-022353-q2k2krnm	906	22	activity	activity	NN
cord-022353-q2k2krnm	906	23	.	.	.
cord-022353-q2k2krnm	907	1	As	as	IN
cord-022353-q2k2krnm	907	2	in	in	IN
cord-022353-q2k2krnm	907	3	other	other	JJ
cord-022353-q2k2krnm	907	4	species	specie	NNS
cord-022353-q2k2krnm	907	5	,	,	,
cord-022353-q2k2krnm	907	6	there	there	EX
cord-022353-q2k2krnm	907	7	are	be	VBP
cord-022353-q2k2krnm	907	8	two	two	CD
cord-022353-q2k2krnm	907	9	major	major	JJ
cord-022353-q2k2krnm	907	10	forms	form	NNS
cord-022353-q2k2krnm	907	11	of	of	IN
cord-022353-q2k2krnm	907	12	AP	AP	NNP
cord-022353-q2k2krnm	907	13	in	in	IN
cord-022353-q2k2krnm	907	14	mice	mouse	NNS
cord-022353-q2k2krnm	907	15	:	:	:
cord-022353-q2k2krnm	907	16	intestinal	intestinal	JJ
cord-022353-q2k2krnm	907	17	AP	AP	NNP
cord-022353-q2k2krnm	907	18	(	(	-LRB-
cord-022353-q2k2krnm	907	19	lAP	lAP	NNP
cord-022353-q2k2krnm	907	20	)	)	-RRB-
cord-022353-q2k2krnm	907	21	and	and	CC
cord-022353-q2k2krnm	907	22	tissue	tissue	VB
cord-022353-q2k2krnm	907	23	nonspecific	nonspecific	JJ
cord-022353-q2k2krnm	907	24	AP	AP	NNP
cord-022353-q2k2krnm	907	25	(	(	-LRB-
cord-022353-q2k2krnm	907	26	TNAP	TNAP	NNP
cord-022353-q2k2krnm	907	27	)	)	-RRB-
cord-022353-q2k2krnm	907	28	.	.	.
cord-022353-q2k2krnm	908	1	Unlike	unlike	IN
cord-022353-q2k2krnm	908	2	other	other	JJ
cord-022353-q2k2krnm	908	3	domestic	domestic	JJ
cord-022353-q2k2krnm	908	4	animal	animal	NN
cord-022353-q2k2krnm	908	5	species	specie	NNS
cord-022353-q2k2krnm	908	6	,	,	,
cord-022353-q2k2krnm	908	7	IAP	IAP	NNP
cord-022353-q2k2krnm	908	8	activity	activity	NN
cord-022353-q2k2krnm	908	9	contributes	contribute	VBZ
cord-022353-q2k2krnm	908	10	to	to	IN
cord-022353-q2k2krnm	908	11	serum	serum	NN
cord-022353-q2k2krnm	908	12	AP	AP	NNP
cord-022353-q2k2krnm	908	13	activity	activity	NN
cord-022353-q2k2krnm	908	14	,	,	,
cord-022353-q2k2krnm	908	15	in	in	IN
cord-022353-q2k2krnm	908	16	addition	addition	NN
cord-022353-q2k2krnm	908	17	to	to	IN
cord-022353-q2k2krnm	908	18	TNAP	TNAP	NNP
cord-022353-q2k2krnm	908	19	.	.	.
cord-022353-q2k2krnm	909	1	lAP	lAP	NNP
cord-022353-q2k2krnm	909	2	is	be	VBZ
cord-022353-q2k2krnm	909	3	located	locate	VBN
cord-022353-q2k2krnm	909	4	along	along	IN
cord-022353-q2k2krnm	909	5	the	the	DT
cord-022353-q2k2krnm	909	6	brush	brush	NN
cord-022353-q2k2krnm	909	7	-	-	HYPH
cord-022353-q2k2krnm	909	8	border	border	NN
cord-022353-q2k2krnm	909	9	of	of	IN
cord-022353-q2k2krnm	909	10	the	the	DT
cord-022353-q2k2krnm	909	11	enterocytes	enterocyte	NNS
cord-022353-q2k2krnm	909	12	.	.	.
cord-022353-q2k2krnm	910	1	Intestinal	intestinal	JJ
cord-022353-q2k2krnm	910	2	AP	AP	NNP
cord-022353-q2k2krnm	910	3	activity	activity	NN
cord-022353-q2k2krnm	910	4	was	be	VBD
cord-022353-q2k2krnm	910	5	shown	show	VBN
cord-022353-q2k2krnm	910	6	to	to	TO
cord-022353-q2k2krnm	910	7	vary	vary	VB
cord-022353-q2k2krnm	910	8	four	four	CD
cord-022353-q2k2krnm	910	9	-	-	RB
cord-022353-q2k2krnm	910	10	fold	fold	RB
cord-022353-q2k2krnm	910	11	between	between	IN
cord-022353-q2k2krnm	910	12	two	two	CD
cord-022353-q2k2krnm	910	13	strains	strain	NNS
cord-022353-q2k2krnm	910	14	of	of	IN
cord-022353-q2k2krnm	910	15	Swiss	swiss	JJ
cord-022353-q2k2krnm	910	16	mice	mouse	NNS
cord-022353-q2k2krnm	910	17	(	(	-LRB-
cord-022353-q2k2krnm	910	18	Nayudu	Nayudu	NNP
cord-022353-q2k2krnm	910	19	and	and	CC
cord-022353-q2k2krnm	910	20	Moog	Moog	NNP
cord-022353-q2k2krnm	910	21	1967	1967	CD
cord-022353-q2k2krnm	910	22	)	)	-RRB-
cord-022353-q2k2krnm	910	23	.	.	.
cord-022353-q2k2krnm	911	1	This	this	DT
cord-022353-q2k2krnm	911	2	difference	difference	NN
cord-022353-q2k2krnm	911	3	in	in	IN
cord-022353-q2k2krnm	911	4	activity	activity	NN
cord-022353-q2k2krnm	911	5	was	be	VBD
cord-022353-q2k2krnm	911	6	under	under	IN
cord-022353-q2k2krnm	911	7	polygenic	polygenic	JJ
cord-022353-q2k2krnm	911	8	control	control	NN
cord-022353-q2k2krnm	911	9	and	and	CC
cord-022353-q2k2krnm	911	10	influenced	influence	VBN
cord-022353-q2k2krnm	911	11	by	by	IN
cord-022353-q2k2krnm	911	12	a	a	DT
cord-022353-q2k2krnm	911	13	strain	strain	NN
cord-022353-q2k2krnm	911	14	-	-	HYPH
cord-022353-q2k2krnm	911	15	specific	specific	JJ
cord-022353-q2k2krnm	911	16	factor	factor	NN
cord-022353-q2k2krnm	911	17	in	in	IN
cord-022353-q2k2krnm	911	18	milk	milk	NN
cord-022353-q2k2krnm	911	19	.	.	.
cord-022353-q2k2krnm	912	1	TNAP	TNAP	NNP
cord-022353-q2k2krnm	912	2	is	be	VBZ
cord-022353-q2k2krnm	912	3	found	find	VBN
cord-022353-q2k2krnm	912	4	in	in	IN
cord-022353-q2k2krnm	912	5	various	various	JJ
cord-022353-q2k2krnm	912	6	tissues	tissue	NNS
cord-022353-q2k2krnm	912	7	,	,	,
cord-022353-q2k2krnm	912	8	and	and	CC
cord-022353-q2k2krnm	912	9	in	in	IN
cord-022353-q2k2krnm	912	10	each	each	DT
cord-022353-q2k2krnm	912	11	location	location	NN
cord-022353-q2k2krnm	912	12	,	,	,
cord-022353-q2k2krnm	912	13	post	post	JJ
cord-022353-q2k2krnm	912	14	-	-	JJ
cord-022353-q2k2krnm	912	15	translation	translation	JJ
cord-022353-q2k2krnm	912	16	modifications	modification	NNS
cord-022353-q2k2krnm	912	17	may	may	MD
cord-022353-q2k2krnm	912	18	result	result	VB
cord-022353-q2k2krnm	912	19	in	in	IN
cord-022353-q2k2krnm	912	20	a	a	DT
cord-022353-q2k2krnm	912	21	different	different	JJ
cord-022353-q2k2krnm	912	22	isoenzyme	isoenzyme	NNS
cord-022353-q2k2krnm	912	23	.	.	.
cord-022353-q2k2krnm	913	1	Hoshi	Hoshi	NNP
cord-022353-q2k2krnm	913	2	et	et	NNP
cord-022353-q2k2krnm	913	3	al	al	NNP
cord-022353-q2k2krnm	913	4	.	.	.
cord-022353-q2k2krnm	914	1	(	(	-LRB-
cord-022353-q2k2krnm	914	2	1997	1997	CD
cord-022353-q2k2krnm	914	3	)	)	-RRB-
cord-022353-q2k2krnm	914	4	used	use	VBN
cord-022353-q2k2krnm	914	5	immunohistochemistry	immunohistochemistry	NN
cord-022353-q2k2krnm	914	6	to	to	TO
cord-022353-q2k2krnm	914	7	localize	localize	VB
cord-022353-q2k2krnm	914	8	these	these	DT
cord-022353-q2k2krnm	914	9	isoenzymes	isoenzyme	NNS
cord-022353-q2k2krnm	914	10	in	in	IN
cord-022353-q2k2krnm	914	11	mice	mouse	NNS
cord-022353-q2k2krnm	914	12	to	to	IN
cord-022353-q2k2krnm	914	13	the	the	DT
cord-022353-q2k2krnm	914	14	following	follow	VBG
cord-022353-q2k2krnm	914	15	locations	location	NNS
cord-022353-q2k2krnm	914	16	:	:	:
cord-022353-q2k2krnm	914	17	bone	bone	NN
cord-022353-q2k2krnm	914	18	tissue	tissue	NN
cord-022353-q2k2krnm	914	19	(	(	-LRB-
cord-022353-q2k2krnm	914	20	specifically	specifically	RB
cord-022353-q2k2krnm	914	21	the	the	DT
cord-022353-q2k2krnm	914	22	entire	entire	JJ
cord-022353-q2k2krnm	914	23	cell	cell	NN
cord-022353-q2k2krnm	914	24	surface	surface	NN
cord-022353-q2k2krnm	914	25	of	of	IN
cord-022353-q2k2krnm	914	26	preosteoblasts	preosteoblast	NNS
cord-022353-q2k2krnm	914	27	and	and	CC
cord-022353-q2k2krnm	914	28	the	the	DT
cord-022353-q2k2krnm	914	29	basolateral	basolateral	JJ
cord-022353-q2k2krnm	914	30	cell	cell	NN
cord-022353-q2k2krnm	914	31	membrane	membrane	NN
cord-022353-q2k2krnm	914	32	of	of	IN
cord-022353-q2k2krnm	914	33	osteoblasts	osteoblast	NNS
cord-022353-q2k2krnm	914	34	)	)	-RRB-
cord-022353-q2k2krnm	914	35	,	,	,
cord-022353-q2k2krnm	914	36	cartilage	cartilage	NN
cord-022353-q2k2krnm	914	37	(	(	-LRB-
cord-022353-q2k2krnm	914	38	mostly	mostly	RB
cord-022353-q2k2krnm	914	39	in	in	IN
cord-022353-q2k2krnm	914	40	chondrocytes	chondrocyte	NNS
cord-022353-q2k2krnm	914	41	of	of	IN
cord-022353-q2k2krnm	914	42	the	the	DT
cord-022353-q2k2krnm	914	43	proliferative	proliferative	JJ
cord-022353-q2k2krnm	914	44	and	and	CC
cord-022353-q2k2krnm	914	45	hypertrophic	hypertrophic	JJ
cord-022353-q2k2krnm	914	46	zones	zone	NNS
cord-022353-q2k2krnm	914	47	)	)	-RRB-
cord-022353-q2k2krnm	914	48	,	,	,
cord-022353-q2k2krnm	914	49	the	the	DT
cord-022353-q2k2krnm	914	50	incisors	incisor	NNS
cord-022353-q2k2krnm	914	51	(	(	-LRB-
cord-022353-q2k2krnm	914	52	particularly	particularly	RB
cord-022353-q2k2krnm	914	53	the	the	DT
cord-022353-q2k2krnm	914	54	cells	cell	NNS
cord-022353-q2k2krnm	914	55	of	of	IN
cord-022353-q2k2krnm	914	56	the	the	DT
cord-022353-q2k2krnm	914	57	stratum	stratum	NN
cord-022353-q2k2krnm	914	58	intermedium	intermedium	NNP
cord-022353-q2k2krnm	914	59	,	,	,
cord-022353-q2k2krnm	914	60	the	the	DT
cord-022353-q2k2krnm	914	61	subodontoblastic	subodontoblastic	JJ
cord-022353-q2k2krnm	914	62	layer	layer	NN
cord-022353-q2k2krnm	914	63	,	,	,
cord-022353-q2k2krnm	914	64	the	the	DT
cord-022353-q2k2krnm	914	65	proximal	proximal	JJ
cord-022353-q2k2krnm	914	66	portion	portion	NN
cord-022353-q2k2krnm	914	67	of	of	IN
cord-022353-q2k2krnm	914	68	secretory	secretory	JJ
cord-022353-q2k2krnm	914	69	ameloblasts	ameloblast	NNS
cord-022353-q2k2krnm	914	70	,	,	,
cord-022353-q2k2krnm	914	71	and	and	CC
cord-022353-q2k2krnm	914	72	the	the	DT
cord-022353-q2k2krnm	914	73	basolateral	basolateral	JJ
cord-022353-q2k2krnm	914	74	portion	portion	NN
cord-022353-q2k2krnm	914	75	of	of	IN
cord-022353-q2k2krnm	914	76	odontoblasts	odontoblast	NNS
cord-022353-q2k2krnm	914	77	)	)	-RRB-
cord-022353-q2k2krnm	914	78	,	,	,
cord-022353-q2k2krnm	914	79	kidneys	kidney	NNS
cord-022353-q2k2krnm	914	80	(	(	-LRB-
cord-022353-q2k2krnm	914	81	on	on	IN
cord-022353-q2k2krnm	914	82	the	the	DT
cord-022353-q2k2krnm	914	83	brush	brush	NN
cord-022353-q2k2krnm	914	84	borders	border	NNS
cord-022353-q2k2krnm	914	85	of	of	IN
cord-022353-q2k2krnm	914	86	proximal	proximal	JJ
cord-022353-q2k2krnm	914	87	renal	renal	JJ
cord-022353-q2k2krnm	914	88	tubules	tubule	NNS
cord-022353-q2k2krnm	914	89	in	in	IN
cord-022353-q2k2krnm	914	90	kidney	kidney	NN
cord-022353-q2k2krnm	914	91	)	)	-RRB-
cord-022353-q2k2krnm	914	92	,	,	,
cord-022353-q2k2krnm	914	93	liver	liver	NN
cord-022353-q2k2krnm	914	94	(	(	-LRB-
cord-022353-q2k2krnm	914	95	on	on	IN
cord-022353-q2k2krnm	914	96	cell	cell	NN
cord-022353-q2k2krnm	914	97	membrane	membrane	NN
cord-022353-q2k2krnm	914	98	of	of	IN
cord-022353-q2k2krnm	914	99	the	the	DT
cord-022353-q2k2krnm	914	100	biliary	biliary	JJ
cord-022353-q2k2krnm	914	101	canaliculi	canaliculi	NNP
cord-022353-q2k2krnm	914	102	)	)	-RRB-
cord-022353-q2k2krnm	914	103	,	,	,
cord-022353-q2k2krnm	914	104	and	and	CC
cord-022353-q2k2krnm	914	105	the	the	DT
cord-022353-q2k2krnm	914	106	placenta	placenta	NN
cord-022353-q2k2krnm	914	107	(	(	-LRB-
cord-022353-q2k2krnm	914	108	on	on	IN
cord-022353-q2k2krnm	914	109	trophoblasts	trophoblast	NNS
cord-022353-q2k2krnm	914	110	)	)	-RRB-
cord-022353-q2k2krnm	914	111	.	.	.
cord-022353-q2k2krnm	915	1	Serum	serum	NN
cord-022353-q2k2krnm	915	2	AP	AP	NNP
cord-022353-q2k2krnm	915	3	activity	activity	NN
cord-022353-q2k2krnm	915	4	can	can	MD
cord-022353-q2k2krnm	915	5	vary	vary	VB
cord-022353-q2k2krnm	915	6	due	due	IN
cord-022353-q2k2krnm	915	7	to	to	IN
cord-022353-q2k2krnm	915	8	the	the	DT
cord-022353-q2k2krnm	915	9	type	type	NN
cord-022353-q2k2krnm	915	10	of	of	IN
cord-022353-q2k2krnm	915	11	assay	assay	NN
cord-022353-q2k2krnm	915	12	used	use	VBN
cord-022353-q2k2krnm	915	13	,	,	,
cord-022353-q2k2krnm	915	14	age	age	NN
cord-022353-q2k2krnm	915	15	,	,	,
cord-022353-q2k2krnm	915	16	sex	sex	NN
cord-022353-q2k2krnm	915	17	,	,	,
cord-022353-q2k2krnm	915	18	and	and	CC
cord-022353-q2k2krnm	915	19	strain	strain	VB
cord-022353-q2k2krnm	915	20	.	.	.
cord-022353-q2k2krnm	916	1	Different	different	JJ
cord-022353-q2k2krnm	916	2	AP	AP	NNP
cord-022353-q2k2krnm	916	3	assays	assay	NNS
cord-022353-q2k2krnm	916	4	vary	vary	VBP
cord-022353-q2k2krnm	916	5	in	in	IN
cord-022353-q2k2krnm	916	6	the	the	DT
cord-022353-q2k2krnm	916	7	type	type	NN
cord-022353-q2k2krnm	916	8	of	of	IN
cord-022353-q2k2krnm	916	9	substrate	substrate	NN
cord-022353-q2k2krnm	916	10	used	use	VBN
cord-022353-q2k2krnm	916	11	,	,	,
cord-022353-q2k2krnm	916	12	the	the	DT
cord-022353-q2k2krnm	916	13	pH	ph	NN
cord-022353-q2k2krnm	916	14	of	of	IN
cord-022353-q2k2krnm	916	15	the	the	DT
cord-022353-q2k2krnm	916	16	reaction	reaction	NN
cord-022353-q2k2krnm	916	17	,	,	,
cord-022353-q2k2krnm	916	18	and	and	CC
cord-022353-q2k2krnm	916	19	the	the	DT
cord-022353-q2k2krnm	916	20	incubation	incubation	NN
cord-022353-q2k2krnm	916	21	temperature	temperature	NN
cord-022353-q2k2krnm	916	22	of	of	IN
cord-022353-q2k2krnm	916	23	the	the	DT
cord-022353-q2k2krnm	916	24	reaction	reaction	NN
cord-022353-q2k2krnm	916	25	,	,	,
cord-022353-q2k2krnm	916	26	all	all	DT
cord-022353-q2k2krnm	916	27	of	of	IN
cord-022353-q2k2krnm	916	28	which	which	WDT
cord-022353-q2k2krnm	916	29	can	can	MD
cord-022353-q2k2krnm	916	30	affect	affect	VB
cord-022353-q2k2krnm	916	31	quantitation	quantitation	NN
cord-022353-q2k2krnm	916	32	of	of	IN
cord-022353-q2k2krnm	916	33	AP	AP	NNP
cord-022353-q2k2krnm	916	34	activity	activity	NN
cord-022353-q2k2krnm	916	35	.	.	.
cord-022353-q2k2krnm	917	1	For	for	IN
cord-022353-q2k2krnm	917	2	example	example	NN
cord-022353-q2k2krnm	917	3	,	,	,
cord-022353-q2k2krnm	917	4	the	the	DT
cord-022353-q2k2krnm	917	5	Hausamen	Hausamen	NNP
cord-022353-q2k2krnm	917	6	technique	technique	NN
cord-022353-q2k2krnm	917	7	can	can	MD
cord-022353-q2k2krnm	917	8	detect	detect	VB
cord-022353-q2k2krnm	917	9	renal	renal	JJ
cord-022353-q2k2krnm	917	10	and	and	CC
cord-022353-q2k2krnm	917	11	intestinal	intestinal	JJ
cord-022353-q2k2krnm	917	12	AP	AP	NNP
cord-022353-q2k2krnm	917	13	activity	activity	NN
cord-022353-q2k2krnm	917	14	,	,	,
cord-022353-q2k2krnm	917	15	but	but	CC
cord-022353-q2k2krnm	917	16	not	not	RB
cord-022353-q2k2krnm	917	17	hepatic	hepatic	JJ
cord-022353-q2k2krnm	917	18	AP	AP	NNP
cord-022353-q2k2krnm	917	19	activity	activity	NN
cord-022353-q2k2krnm	918	1	(	(	-LRB-
cord-022353-q2k2krnm	918	2	Hausamen	Hausamen	NNP
cord-022353-q2k2krnm	918	3	et	et	NNP
cord-022353-q2k2krnm	918	4	al	al	NNP
cord-022353-q2k2krnm	918	5	.	.	.
cord-022353-q2k2krnm	918	6	1967	1967	CD
cord-022353-q2k2krnm	918	7	)	)	-RRB-
cord-022353-q2k2krnm	918	8	.	.	.
cord-022353-q2k2krnm	919	1	Loeb	Loeb	NNP
cord-022353-q2k2krnm	919	2	et	et	NNP
cord-022353-q2k2krnm	919	3	al	al	NNP
cord-022353-q2k2krnm	919	4	.	.	.
cord-022353-q2k2krnm	920	1	(	(	-LRB-
cord-022353-q2k2krnm	920	2	1996	1996	CD
cord-022353-q2k2krnm	920	3	)	)	-RRB-
cord-022353-q2k2krnm	921	1	and	and	CC
cord-022353-q2k2krnm	921	2	Frith	Frith	NNP
cord-022353-q2k2krnm	921	3	et	et	NNP
cord-022353-q2k2krnm	921	4	al	al	NNP
cord-022353-q2k2krnm	921	5	.	.	.
cord-022353-q2k2krnm	922	1	(	(	-LRB-
cord-022353-q2k2krnm	922	2	1980	1980	CD
cord-022353-q2k2krnm	922	3	demonstrated	demonstrate	VBD
cord-022353-q2k2krnm	922	4	that	that	IN
cord-022353-q2k2krnm	922	5	serum	serum	NN
cord-022353-q2k2krnm	922	6	AP	AP	NNP
cord-022353-q2k2krnm	922	7	activity	activity	NN
cord-022353-q2k2krnm	922	8	decrease	decrease	NN
cord-022353-q2k2krnm	922	9	significantly	significantly	RB
cord-022353-q2k2krnm	922	10	after	after	IN
cord-022353-q2k2krnm	922	11	3	3	CD
cord-022353-q2k2krnm	922	12	months	month	NNS
cord-022353-q2k2krnm	922	13	of	of	IN
cord-022353-q2k2krnm	922	14	age	age	NN
cord-022353-q2k2krnm	922	15	in	in	IN
cord-022353-q2k2krnm	922	16	BALB	BALB	NNP
cord-022353-q2k2krnm	922	17	/	/	SYM
cord-022353-q2k2krnm	922	18	c	c	NN
cord-022353-q2k2krnm	922	19	and	and	CC
cord-022353-q2k2krnm	922	20	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	922	21	mice	mouse	NNS
cord-022353-q2k2krnm	922	22	of	of	IN
cord-022353-q2k2krnm	922	23	both	both	DT
cord-022353-q2k2krnm	922	24	sexes	sex	NNS
cord-022353-q2k2krnm	922	25	but	but	CC
cord-022353-q2k2krnm	922	26	increase	increase	VB
cord-022353-q2k2krnm	922	27	again	again	RB
cord-022353-q2k2krnm	922	28	in	in	IN
cord-022353-q2k2krnm	922	29	very	very	RB
cord-022353-q2k2krnm	922	30	old	old	JJ
cord-022353-q2k2krnm	922	31	(	(	-LRB-
cord-022353-q2k2krnm	922	32	36	36	CD
cord-022353-q2k2krnm	922	33	month	month	NN
cord-022353-q2k2krnm	922	34	old	old	JJ
cord-022353-q2k2krnm	922	35	)	)	-RRB-
cord-022353-q2k2krnm	922	36	mice	mouse	NNS
cord-022353-q2k2krnm	922	37	.	.	.
cord-022353-q2k2krnm	923	1	The	the	DT
cord-022353-q2k2krnm	923	2	high	high	JJ
cord-022353-q2k2krnm	923	3	levels	level	NNS
cord-022353-q2k2krnm	923	4	of	of	IN
cord-022353-q2k2krnm	923	5	serum	serum	NN
cord-022353-q2k2krnm	923	6	AP	AP	NNP
cord-022353-q2k2krnm	923	7	seen	see	VBN
cord-022353-q2k2krnm	923	8	in	in	IN
cord-022353-q2k2krnm	923	9	juveniles	juvenile	NNS
cord-022353-q2k2krnm	923	10	is	be	VBZ
cord-022353-q2k2krnm	923	11	related	relate	VBN
cord-022353-q2k2krnm	923	12	to	to	IN
cord-022353-q2k2krnm	923	13	increases	increase	NNS
cord-022353-q2k2krnm	923	14	in	in	IN
cord-022353-q2k2krnm	923	15	the	the	DT
cord-022353-q2k2krnm	923	16	bone	bone	NN
cord-022353-q2k2krnm	923	17	AP	AP	NNP
cord-022353-q2k2krnm	923	18	isoenzymes	isoenzymes	NNP
cord-022353-q2k2krnm	923	19	,	,	,
cord-022353-q2k2krnm	923	20	which	which	WDT
cord-022353-q2k2krnm	923	21	is	be	VBZ
cord-022353-q2k2krnm	923	22	associated	associate	VBN
cord-022353-q2k2krnm	923	23	with	with	IN
cord-022353-q2k2krnm	923	24	osteoblastic	osteoblastic	JJ
cord-022353-q2k2krnm	923	25	activity	activity	NN
cord-022353-q2k2krnm	923	26	due	due	IN
cord-022353-q2k2krnm	923	27	to	to	IN
cord-022353-q2k2krnm	923	28	rapid	rapid	JJ
cord-022353-q2k2krnm	923	29	growth	growth	NN
cord-022353-q2k2krnm	923	30	.	.	.
cord-022353-q2k2krnm	924	1	Picketing	picket	VBG
cord-022353-q2k2krnm	924	2	and	and	CC
cord-022353-q2k2krnm	924	3	Picketing	Picketing	NNP
cord-022353-q2k2krnm	924	4	(	(	-LRB-
cord-022353-q2k2krnm	924	5	1984	1984	CD
cord-022353-q2k2krnm	924	6	)	)	-RRB-
cord-022353-q2k2krnm	924	7	showed	show	VBD
cord-022353-q2k2krnm	924	8	that	that	IN
cord-022353-q2k2krnm	924	9	serum	serum	NN
cord-022353-q2k2krnm	924	10	AP	AP	NNP
cord-022353-q2k2krnm	924	11	activity	activity	NN
cord-022353-q2k2krnm	924	12	is	be	VBZ
cord-022353-q2k2krnm	924	13	lower	low	JJR
cord-022353-q2k2krnm	924	14	in	in	IN
cord-022353-q2k2krnm	924	15	males	male	NNS
cord-022353-q2k2krnm	924	16	than	than	IN
cord-022353-q2k2krnm	924	17	in	in	IN
cord-022353-q2k2krnm	924	18	females	female	NNS
cord-022353-q2k2krnm	924	19	.	.	.
cord-022353-q2k2krnm	925	1	Quantification	quantification	NN
cord-022353-q2k2krnm	925	2	of	of	IN
cord-022353-q2k2krnm	925	3	serum	serum	NN
cord-022353-q2k2krnm	925	4	AP	AP	NNP
cord-022353-q2k2krnm	925	5	measures	measure	VBZ
cord-022353-q2k2krnm	925	6	the	the	DT
cord-022353-q2k2krnm	925	7	total	total	JJ
cord-022353-q2k2krnm	925	8	AP	AP	NNP
cord-022353-q2k2krnm	925	9	activity	activity	NN
cord-022353-q2k2krnm	925	10	from	from	IN
cord-022353-q2k2krnm	925	11	all	all	DT
cord-022353-q2k2krnm	925	12	sources	source	NNS
cord-022353-q2k2krnm	925	13	,	,	,
cord-022353-q2k2krnm	925	14	and	and	CC
cord-022353-q2k2krnm	925	15	therefore	therefore	RB
cord-022353-q2k2krnm	925	16	elevations	elevation	NNS
cord-022353-q2k2krnm	925	17	in	in	IN
cord-022353-q2k2krnm	925	18	AP	AP	NNP
cord-022353-q2k2krnm	925	19	activity	activity	NN
cord-022353-q2k2krnm	925	20	can	can	MD
cord-022353-q2k2krnm	925	21	be	be	VB
cord-022353-q2k2krnm	925	22	a	a	DT
cord-022353-q2k2krnm	925	23	nonspecific	nonspecific	JJ
cord-022353-q2k2krnm	925	24	determinant	determinant	NN
cord-022353-q2k2krnm	925	25	of	of	IN
cord-022353-q2k2krnm	925	26	tissue	tissue	NN
cord-022353-q2k2krnm	925	27	dysfunction	dysfunction	NN
cord-022353-q2k2krnm	925	28	,	,	,
cord-022353-q2k2krnm	925	29	depending	depend	VBG
cord-022353-q2k2krnm	925	30	on	on	IN
cord-022353-q2k2krnm	925	31	the	the	DT
cord-022353-q2k2krnm	925	32	tissue	tissue	NN
cord-022353-q2k2krnm	925	33	(	(	-LRB-
cord-022353-q2k2krnm	925	34	and	and	CC
cord-022353-q2k2krnm	925	35	therefore	therefore	RB
cord-022353-q2k2krnm	925	36	AP	AP	NNP
cord-022353-q2k2krnm	925	37	isoenzyme	isoenzyme	NNP
cord-022353-q2k2krnm	925	38	)	)	-RRB-
cord-022353-q2k2krnm	925	39	involved	involve	VBN
cord-022353-q2k2krnm	925	40	.	.	.
cord-022353-q2k2krnm	926	1	For	for	IN
cord-022353-q2k2krnm	926	2	example	example	NN
cord-022353-q2k2krnm	926	3	,	,	,
cord-022353-q2k2krnm	926	4	changes	change	NNS
cord-022353-q2k2krnm	926	5	in	in	IN
cord-022353-q2k2krnm	926	6	the	the	DT
cord-022353-q2k2krnm	926	7	serum	serum	NN
cord-022353-q2k2krnm	926	8	activity	activity	NN
cord-022353-q2k2krnm	926	9	of	of	IN
cord-022353-q2k2krnm	926	10	AP	AP	NNP
cord-022353-q2k2krnm	926	11	due	due	IN
cord-022353-q2k2krnm	926	12	to	to	IN
cord-022353-q2k2krnm	926	13	liver	liver	NN
cord-022353-q2k2krnm	926	14	disease	disease	NN
cord-022353-q2k2krnm	926	15	only	only	RB
cord-022353-q2k2krnm	926	16	occur	occur	VBP
cord-022353-q2k2krnm	926	17	if	if	IN
cord-022353-q2k2krnm	926	18	cholestasis	cholestasis	NN
cord-022353-q2k2krnm	926	19	is	be	VBZ
cord-022353-q2k2krnm	926	20	concurrently	concurrently	RB
cord-022353-q2k2krnm	926	21	involved	involve	VBN
cord-022353-q2k2krnm	926	22	.	.	.
cord-022353-q2k2krnm	927	1	Mice	mouse	NNS
cord-022353-q2k2krnm	927	2	lacking	lack	VBG
cord-022353-q2k2krnm	927	3	the	the	DT
cord-022353-q2k2krnm	927	4	gene	gene	NN
cord-022353-q2k2krnm	927	5	that	that	WDT
cord-022353-q2k2krnm	927	6	modifies	modify	VBZ
cord-022353-q2k2krnm	927	7	TNAP	TNAP	NNP
cord-022353-q2k2krnm	927	8	into	into	IN
cord-022353-q2k2krnm	927	9	the	the	DT
cord-022353-q2k2krnm	927	10	bone	bone	NN
cord-022353-q2k2krnm	927	11	isoenzyme	isoenzyme	NNS
cord-022353-q2k2krnm	927	12	suffer	suffer	VBP
cord-022353-q2k2krnm	927	13	from	from	IN
cord-022353-q2k2krnm	927	14	skeletal	skeletal	JJ
cord-022353-q2k2krnm	927	15	hypomineralization	hypomineralization	NN
cord-022353-q2k2krnm	927	16	(	(	-LRB-
cord-022353-q2k2krnm	927	17	Anderson	Anderson	NNP
cord-022353-q2k2krnm	927	18	et	et	NNP
cord-022353-q2k2krnm	927	19	al	al	NNP
cord-022353-q2k2krnm	927	20	.	.	.
cord-022353-q2k2krnm	927	21	2004	2004	CD
cord-022353-q2k2krnm	927	22	)	)	-RRB-
cord-022353-q2k2krnm	927	23	.	.	.
cord-022353-q2k2krnm	928	1	ALT	ALT	NNP
cord-022353-q2k2krnm	928	2	is	be	VBZ
cord-022353-q2k2krnm	928	3	a	a	DT
cord-022353-q2k2krnm	928	4	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	928	5	enzyme	enzyme	NN
cord-022353-q2k2krnm	928	6	in	in	IN
cord-022353-q2k2krnm	928	7	which	which	WDT
cord-022353-q2k2krnm	928	8	serum	serum	NN
cord-022353-q2k2krnm	928	9	activity	activity	NN
cord-022353-q2k2krnm	928	10	is	be	VBZ
cord-022353-q2k2krnm	928	11	increased	increase	VBN
cord-022353-q2k2krnm	928	12	due	due	IN
cord-022353-q2k2krnm	928	13	to	to	IN
cord-022353-q2k2krnm	928	14	leakage	leakage	VB
cord-022353-q2k2krnm	928	15	across	across	IN
cord-022353-q2k2krnm	928	16	damaged	damage	VBN
cord-022353-q2k2krnm	928	17	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	928	18	membranes	membrane	NNS
cord-022353-q2k2krnm	928	19	.	.	.
cord-022353-q2k2krnm	929	1	ALT	ALT	NNP
cord-022353-q2k2krnm	929	2	(	(	-LRB-
cord-022353-q2k2krnm	929	3	also	also	RB
cord-022353-q2k2krnm	929	4	known	know	VBN
cord-022353-q2k2krnm	929	5	as	as	IN
cord-022353-q2k2krnm	929	6	glutamic	glutamic	NN
cord-022353-q2k2krnm	929	7	pyruvic	pyruvic	NN
cord-022353-q2k2krnm	929	8	transaminase	transaminase	NN
cord-022353-q2k2krnm	929	9	[	[	-LRB-
cord-022353-q2k2krnm	929	10	GPT	gpt	NN
cord-022353-q2k2krnm	929	11	]	]	-RRB-
cord-022353-q2k2krnm	929	12	)	)	-RRB-
cord-022353-q2k2krnm	930	1	reversibly	reversibly	RB
cord-022353-q2k2krnm	930	2	catalyzes	catalyze	VBZ
cord-022353-q2k2krnm	930	3	the	the	DT
cord-022353-q2k2krnm	930	4	conversion	conversion	NN
cord-022353-q2k2krnm	930	5	of	of	IN
cord-022353-q2k2krnm	930	6	alanine	alanine	NN
cord-022353-q2k2krnm	930	7	to	to	IN
cord-022353-q2k2krnm	930	8	pyruvate	pyruvate	VB
cord-022353-q2k2krnm	930	9	.	.	.
cord-022353-q2k2krnm	931	1	Quantification	quantification	NN
cord-022353-q2k2krnm	931	2	of	of	IN
cord-022353-q2k2krnm	931	3	serum	serum	NN
cord-022353-q2k2krnm	931	4	ALT	alt	NN
cord-022353-q2k2krnm	931	5	is	be	VBZ
cord-022353-q2k2krnm	931	6	based	base	VBN
cord-022353-q2k2krnm	931	7	on	on	IN
cord-022353-q2k2krnm	931	8	a	a	DT
cord-022353-q2k2krnm	931	9	reaction	reaction	NN
cord-022353-q2k2krnm	931	10	between	between	IN
cord-022353-q2k2krnm	931	11	ALT	alt	NN
cord-022353-q2k2krnm	931	12	and	and	CC
cord-022353-q2k2krnm	931	13	a	a	DT
cord-022353-q2k2krnm	931	14	suitable	suitable	JJ
cord-022353-q2k2krnm	931	15	substrate	substrate	NN
cord-022353-q2k2krnm	931	16	(	(	-LRB-
cord-022353-q2k2krnm	931	17	such	such	JJ
cord-022353-q2k2krnm	931	18	as	as	IN
cord-022353-q2k2krnm	931	19	alanine	alanine	NN
cord-022353-q2k2krnm	931	20	)	)	-RRB-
cord-022353-q2k2krnm	931	21	.	.	.
cord-022353-q2k2krnm	932	1	In	in	IN
cord-022353-q2k2krnm	932	2	mice	mouse	NNS
cord-022353-q2k2krnm	932	3	,	,	,
cord-022353-q2k2krnm	932	4	ALT	ALT	NNP
cord-022353-q2k2krnm	932	5	is	be	VBZ
cord-022353-q2k2krnm	932	6	found	find	VBN
cord-022353-q2k2krnm	932	7	in	in	IN
cord-022353-q2k2krnm	932	8	the	the	DT
cord-022353-q2k2krnm	932	9	highest	high	JJS
cord-022353-q2k2krnm	932	10	concentrations	concentration	NNS
cord-022353-q2k2krnm	932	11	in	in	IN
cord-022353-q2k2krnm	932	12	the	the	DT
cord-022353-q2k2krnm	932	13	liver	liver	NN
cord-022353-q2k2krnm	932	14	,	,	,
cord-022353-q2k2krnm	932	15	although	although	IN
cord-022353-q2k2krnm	932	16	activity	activity	NN
cord-022353-q2k2krnm	932	17	has	have	VBZ
cord-022353-q2k2krnm	932	18	also	also	RB
cord-022353-q2k2krnm	932	19	been	be	VBN
cord-022353-q2k2krnm	932	20	demonstrated	demonstrate	VBN
cord-022353-q2k2krnm	932	21	in	in	IN
cord-022353-q2k2krnm	932	22	intestine	intestine	NN
cord-022353-q2k2krnm	932	23	,	,	,
cord-022353-q2k2krnm	932	24	kidney	kidney	NN
cord-022353-q2k2krnm	932	25	,	,	,
cord-022353-q2k2krnm	932	26	heart	heart	NN
cord-022353-q2k2krnm	932	27	,	,	,
cord-022353-q2k2krnm	932	28	muscle	muscle	NN
cord-022353-q2k2krnm	932	29	,	,	,
cord-022353-q2k2krnm	932	30	and	and	CC
cord-022353-q2k2krnm	932	31	brain	brain	NN
cord-022353-q2k2krnm	932	32	(	(	-LRB-
cord-022353-q2k2krnm	932	33	Clampitt	Clampitt	NNP
cord-022353-q2k2krnm	932	34	and	and	CC
cord-022353-q2k2krnm	932	35	Hart	Hart	NNP
cord-022353-q2k2krnm	932	36	1978	1978	CD
cord-022353-q2k2krnm	932	37	)	)	-RRB-
cord-022353-q2k2krnm	932	38	.	.	.
cord-022353-q2k2krnm	933	1	Despite	despite	IN
cord-022353-q2k2krnm	933	2	its	-PRON-	PRP$
cord-022353-q2k2krnm	933	3	widespread	widespread	JJ
cord-022353-q2k2krnm	933	4	tissue	tissue	NN
cord-022353-q2k2krnm	933	5	distribution	distribution	NN
cord-022353-q2k2krnm	933	6	,	,	,
cord-022353-q2k2krnm	933	7	ALT	ALT	NNP
cord-022353-q2k2krnm	933	8	is	be	VBZ
cord-022353-q2k2krnm	933	9	mostly	mostly	RB
cord-022353-q2k2krnm	933	10	used	use	VBN
cord-022353-q2k2krnm	933	11	as	as	IN
cord-022353-q2k2krnm	933	12	an	an	DT
cord-022353-q2k2krnm	933	13	analyte	analyte	NN
cord-022353-q2k2krnm	933	14	to	to	TO
cord-022353-q2k2krnm	933	15	assess	assess	VB
cord-022353-q2k2krnm	933	16	hepatocellular	hepatocellular	JJ
cord-022353-q2k2krnm	933	17	damage	damage	NN
cord-022353-q2k2krnm	934	1	(	(	-LRB-
cord-022353-q2k2krnm	934	2	Masaki	Masaki	NNP
cord-022353-q2k2krnm	934	3	et	et	NNP
cord-022353-q2k2krnm	934	4	al	al	NNP
cord-022353-q2k2krnm	934	5	.	.	.
cord-022353-q2k2krnm	935	1	2005	2005	CD
cord-022353-q2k2krnm	935	2	;	;	:
cord-022353-q2k2krnm	935	3	Taieb	Taieb	NNP
cord-022353-q2k2krnm	935	4	et	et	NNP
cord-022353-q2k2krnm	935	5	al	al	NNP
cord-022353-q2k2krnm	935	6	.	.	NNP
cord-022353-q2k2krnm	935	7	2005	2005	CD
cord-022353-q2k2krnm	935	8	)	)	-RRB-
cord-022353-q2k2krnm	935	9	.	.	.
cord-022353-q2k2krnm	936	1	An	an	DT
cord-022353-q2k2krnm	936	2	11,000	11,000	CD
cord-022353-q2k2krnm	936	3	%	%	NN
cord-022353-q2k2krnm	936	4	increase	increase	NN
cord-022353-q2k2krnm	936	5	in	in	IN
cord-022353-q2k2krnm	936	6	serum	serum	NN
cord-022353-q2k2krnm	936	7	ALT	alt	NN
cord-022353-q2k2krnm	936	8	activity	activity	NN
cord-022353-q2k2krnm	936	9	has	have	VBZ
cord-022353-q2k2krnm	936	10	been	be	VBN
cord-022353-q2k2krnm	936	11	reported	report	VBN
cord-022353-q2k2krnm	936	12	following	follow	VBG
cord-022353-q2k2krnm	936	13	infection	infection	NN
cord-022353-q2k2krnm	936	14	with	with	IN
cord-022353-q2k2krnm	936	15	mouse	mouse	NN
cord-022353-q2k2krnm	936	16	hepatitis	hepatitis	NNP
cord-022353-q2k2krnm	936	17	virus	virus	NN
cord-022353-q2k2krnm	936	18	,	,	,
cord-022353-q2k2krnm	936	19	and	and	CC
cord-022353-q2k2krnm	936	20	significant	significant	JJ
cord-022353-q2k2krnm	936	21	increases	increase	NNS
cord-022353-q2k2krnm	936	22	follow	follow	VBP
cord-022353-q2k2krnm	936	23	infection	infection	NN
cord-022353-q2k2krnm	936	24	by	by	IN
cord-022353-q2k2krnm	936	25	Helicobacter	Helicobacter	NNP
cord-022353-q2k2krnm	936	26	hepaticus	hepaticus	NNP
cord-022353-q2k2krnm	937	1	(	(	-LRB-
cord-022353-q2k2krnm	937	2	McCathey	McCathey	NNP
cord-022353-q2k2krnm	937	3	et	et	FW
cord-022353-q2k2krnm	937	4	al	al	NNP
cord-022353-q2k2krnm	937	5	.	.	.
cord-022353-q2k2krnm	937	6	1997	1997	CD
cord-022353-q2k2krnm	937	7	)	)	-RRB-
cord-022353-q2k2krnm	937	8	.	.	.
cord-022353-q2k2krnm	938	1	AST	AST	NNP
cord-022353-q2k2krnm	938	2	is	be	VBZ
cord-022353-q2k2krnm	938	3	a	a	DT
cord-022353-q2k2krnm	938	4	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	938	5	and	and	CC
cord-022353-q2k2krnm	938	6	mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	938	7	enzyme	enzyme	NN
cord-022353-q2k2krnm	938	8	in	in	IN
cord-022353-q2k2krnm	938	9	which	which	WDT
cord-022353-q2k2krnm	938	10	serum	serum	NN
cord-022353-q2k2krnm	938	11	activity	activity	NN
cord-022353-q2k2krnm	938	12	is	be	VBZ
cord-022353-q2k2krnm	938	13	increased	increase	VBN
cord-022353-q2k2krnm	938	14	due	due	IN
cord-022353-q2k2krnm	938	15	to	to	IN
cord-022353-q2k2krnm	938	16	leakage	leakage	VB
cord-022353-q2k2krnm	938	17	across	across	IN
cord-022353-q2k2krnm	938	18	damaged	damage	VBN
cord-022353-q2k2krnm	938	19	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	938	20	and	and	CC
cord-022353-q2k2krnm	938	21	mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	938	22	membranes	membrane	NNS
cord-022353-q2k2krnm	938	23	.	.	.
cord-022353-q2k2krnm	939	1	AST	AST	NNP
cord-022353-q2k2krnm	939	2	(	(	-LRB-
cord-022353-q2k2krnm	939	3	also	also	RB
cord-022353-q2k2krnm	939	4	known	know	VBN
cord-022353-q2k2krnm	939	5	as	as	IN
cord-022353-q2k2krnm	939	6	glutamic	glutamic	NN
cord-022353-q2k2krnm	940	1	oxaloacetate	oxaloacetate	NNP
cord-022353-q2k2krnm	940	2	transaminase	transaminase	FW
cord-022353-q2k2krnm	940	3	[	[	-LRB-
cord-022353-q2k2krnm	940	4	GOT	get	VBD
cord-022353-q2k2krnm	940	5	]	]	-RRB-
cord-022353-q2k2krnm	940	6	)	)	-RRB-
cord-022353-q2k2krnm	941	1	reversibly	reversibly	RB
cord-022353-q2k2krnm	941	2	catalyzes	catalyze	VBZ
cord-022353-q2k2krnm	941	3	the	the	DT
cord-022353-q2k2krnm	941	4	conversion	conversion	NN
cord-022353-q2k2krnm	941	5	of	of	IN
cord-022353-q2k2krnm	941	6	aspartate	aspartate	NN
cord-022353-q2k2krnm	941	7	to	to	IN
cord-022353-q2k2krnm	941	8	oxaloacetate	oxaloacetate	NNP
cord-022353-q2k2krnm	941	9	.	.	.
cord-022353-q2k2krnm	942	1	Quantification	quantification	NN
cord-022353-q2k2krnm	942	2	of	of	IN
cord-022353-q2k2krnm	942	3	serum	serum	NN
cord-022353-q2k2krnm	942	4	AST	ast	NN
cord-022353-q2k2krnm	942	5	is	be	VBZ
cord-022353-q2k2krnm	942	6	based	base	VBN
cord-022353-q2k2krnm	942	7	on	on	IN
cord-022353-q2k2krnm	942	8	a	a	DT
cord-022353-q2k2krnm	942	9	reaction	reaction	NN
cord-022353-q2k2krnm	942	10	between	between	IN
cord-022353-q2k2krnm	942	11	AST	ast	NN
cord-022353-q2k2krnm	942	12	and	and	CC
cord-022353-q2k2krnm	942	13	a	a	DT
cord-022353-q2k2krnm	942	14	suitable	suitable	JJ
cord-022353-q2k2krnm	942	15	substrate	substrate	NN
cord-022353-q2k2krnm	942	16	(	(	-LRB-
cord-022353-q2k2krnm	942	17	such	such	JJ
cord-022353-q2k2krnm	942	18	as	as	IN
cord-022353-q2k2krnm	942	19	aspartate	aspartate	NN
cord-022353-q2k2krnm	942	20	)	)	-RRB-
cord-022353-q2k2krnm	942	21	.	.	.
cord-022353-q2k2krnm	943	1	In	in	IN
cord-022353-q2k2krnm	943	2	mice	mouse	NNS
cord-022353-q2k2krnm	943	3	,	,	,
cord-022353-q2k2krnm	943	4	AST	AST	NNP
cord-022353-q2k2krnm	943	5	is	be	VBZ
cord-022353-q2k2krnm	943	6	found	find	VBN
cord-022353-q2k2krnm	943	7	in	in	IN
cord-022353-q2k2krnm	943	8	a	a	DT
cord-022353-q2k2krnm	943	9	variety	variety	NN
cord-022353-q2k2krnm	943	10	of	of	IN
cord-022353-q2k2krnm	943	11	tissues	tissue	NNS
cord-022353-q2k2krnm	943	12	,	,	,
cord-022353-q2k2krnm	943	13	including	include	VBG
cord-022353-q2k2krnm	943	14	liver	liver	NN
cord-022353-q2k2krnm	943	15	,	,	,
cord-022353-q2k2krnm	943	16	skeletal	skeletal	JJ
cord-022353-q2k2krnm	943	17	muscle	muscle	NN
cord-022353-q2k2krnm	943	18	,	,	,
cord-022353-q2k2krnm	943	19	cardiac	cardiac	JJ
cord-022353-q2k2krnm	943	20	muscle	muscle	NN
cord-022353-q2k2krnm	943	21	,	,	,
cord-022353-q2k2krnm	943	22	erythrocytes	erythrocyte	NNS
cord-022353-q2k2krnm	943	23	,	,	,
cord-022353-q2k2krnm	943	24	blood	blood	NN
cord-022353-q2k2krnm	943	25	vessels	vessel	NNS
cord-022353-q2k2krnm	943	26	,	,	,
cord-022353-q2k2krnm	943	27	brain	brain	NN
cord-022353-q2k2krnm	943	28	,	,	,
cord-022353-q2k2krnm	943	29	intestine	intestine	NN
cord-022353-q2k2krnm	943	30	,	,	,
cord-022353-q2k2krnm	943	31	kidney	kidney	NN
cord-022353-q2k2krnm	943	32	,	,	,
cord-022353-q2k2krnm	943	33	lung	lung	NN
cord-022353-q2k2krnm	943	34	,	,	,
cord-022353-q2k2krnm	943	35	testes	testis	NNS
cord-022353-q2k2krnm	943	36	(	(	-LRB-
cord-022353-q2k2krnm	943	37	Papadimitriou	Papadimitriou	NNP
cord-022353-q2k2krnm	943	38	and	and	CC
cord-022353-q2k2krnm	943	39	Van	Van	NNP
cord-022353-q2k2krnm	943	40	Duijn	Duijn	NNP
cord-022353-q2k2krnm	943	41	1970	1970	CD
cord-022353-q2k2krnm	943	42	)	)	-RRB-
cord-022353-q2k2krnm	943	43	.	.	.
cord-022353-q2k2krnm	944	1	The	the	DT
cord-022353-q2k2krnm	944	2	highest	highest	RBS
cord-022353-q2k2krnm	944	3	specific	specific	JJ
cord-022353-q2k2krnm	944	4	activity	activity	NN
cord-022353-q2k2krnm	944	5	of	of	IN
cord-022353-q2k2krnm	944	6	AST	AST	NNP
cord-022353-q2k2krnm	944	7	is	be	VBZ
cord-022353-q2k2krnm	944	8	found	find	VBN
cord-022353-q2k2krnm	944	9	in	in	IN
cord-022353-q2k2krnm	944	10	mouse	mouse	NN
cord-022353-q2k2krnm	944	11	cardiac	cardiac	JJ
cord-022353-q2k2krnm	944	12	muscle	muscle	NN
cord-022353-q2k2krnm	944	13	and	and	CC
cord-022353-q2k2krnm	944	14	lowest	low	JJS
cord-022353-q2k2krnm	944	15	in	in	IN
cord-022353-q2k2krnm	944	16	skeletal	skeletal	JJ
cord-022353-q2k2krnm	944	17	muscle	muscle	NN
cord-022353-q2k2krnm	944	18	(	(	-LRB-
cord-022353-q2k2krnm	944	19	Herzfeld	Herzfeld	NNP
cord-022353-q2k2krnm	944	20	and	and	CC
cord-022353-q2k2krnm	944	21	Knox	Knox	NNP
cord-022353-q2k2krnm	944	22	1971	1971	CD
cord-022353-q2k2krnm	944	23	)	)	-RRB-
cord-022353-q2k2krnm	944	24	.	.	.
cord-022353-q2k2krnm	945	1	In	in	IN
cord-022353-q2k2krnm	945	2	the	the	DT
cord-022353-q2k2krnm	945	3	liver	liver	NN
cord-022353-q2k2krnm	945	4	,	,	,
cord-022353-q2k2krnm	945	5	AST	AST	NNP
cord-022353-q2k2krnm	945	6	is	be	VBZ
cord-022353-q2k2krnm	945	7	found	find	VBN
cord-022353-q2k2krnm	945	8	mainly	mainly	RB
cord-022353-q2k2krnm	945	9	in	in	IN
cord-022353-q2k2krnm	945	10	periportal	periportal	JJ
cord-022353-q2k2krnm	945	11	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	945	12	based	base	VBN
cord-022353-q2k2krnm	945	13	on	on	IN
cord-022353-q2k2krnm	945	14	histochemical	histochemical	JJ
cord-022353-q2k2krnm	945	15	studies	study	NNS
cord-022353-q2k2krnm	945	16	(	(	-LRB-
cord-022353-q2k2krnm	945	17	Papadimitriou	Papadimitriou	NNP
cord-022353-q2k2krnm	945	18	and	and	CC
cord-022353-q2k2krnm	945	19	Van	Van	NNP
cord-022353-q2k2krnm	945	20	Duijn	Duijn	NNP
cord-022353-q2k2krnm	945	21	1970	1970	CD
cord-022353-q2k2krnm	945	22	)	)	-RRB-
cord-022353-q2k2krnm	945	23	.	.	.
cord-022353-q2k2krnm	946	1	Activity	activity	NN
cord-022353-q2k2krnm	946	2	in	in	IN
cord-022353-q2k2krnm	946	3	lung	lung	NN
cord-022353-q2k2krnm	946	4	,	,	,
cord-022353-q2k2krnm	946	5	kidney	kidney	NN
cord-022353-q2k2krnm	946	6	,	,	,
cord-022353-q2k2krnm	946	7	intestine	intestine	NN
cord-022353-q2k2krnm	946	8	,	,	,
cord-022353-q2k2krnm	946	9	and	and	CC
cord-022353-q2k2krnm	946	10	skeletal	skeletal	JJ
cord-022353-q2k2krnm	946	11	muscle	muscle	NN
cord-022353-q2k2krnm	946	12	is	be	VBZ
cord-022353-q2k2krnm	946	13	very	very	RB
cord-022353-q2k2krnm	946	14	low	low	JJ
cord-022353-q2k2krnm	946	15	when	when	WRB
cord-022353-q2k2krnm	946	16	measured	measure	VBN
cord-022353-q2k2krnm	946	17	by	by	IN
cord-022353-q2k2krnm	946	18	the	the	DT
cord-022353-q2k2krnm	946	19	technique	technique	NN
cord-022353-q2k2krnm	946	20	of	of	IN
cord-022353-q2k2krnm	946	21	Bergmeyer	Bergmeyer	NNP
cord-022353-q2k2krnm	946	22	and	and	CC
cord-022353-q2k2krnm	946	23	Bernt	Bernt	NNP
cord-022353-q2k2krnm	946	24	(	(	-LRB-
cord-022353-q2k2krnm	946	25	1974	1974	CD
cord-022353-q2k2krnm	946	26	)	)	-RRB-
cord-022353-q2k2krnm	946	27	.	.	.
cord-022353-q2k2krnm	947	1	Loeb	Loeb	NNP
cord-022353-q2k2krnm	947	2	et	et	NNP
cord-022353-q2k2krnm	947	3	al	al	NNP
cord-022353-q2k2krnm	947	4	.	.	.
cord-022353-q2k2krnm	948	1	(	(	-LRB-
cord-022353-q2k2krnm	948	2	1996	1996	CD
cord-022353-q2k2krnm	948	3	)	)	-RRB-
cord-022353-q2k2krnm	948	4	demonstrate	demonstrate	VBP
cord-022353-q2k2krnm	948	5	significant	significant	JJ
cord-022353-q2k2krnm	948	6	age	age	NN
cord-022353-q2k2krnm	948	7	-	-	HYPH
cord-022353-q2k2krnm	948	8	associated	associate	VBN
cord-022353-q2k2krnm	948	9	increases	increase	NNS
cord-022353-q2k2krnm	948	10	in	in	IN
cord-022353-q2k2krnm	948	11	serum	serum	NN
cord-022353-q2k2krnm	948	12	AST	ast	NN
cord-022353-q2k2krnm	948	13	activity	activity	NN
cord-022353-q2k2krnm	948	14	in	in	IN
cord-022353-q2k2krnm	948	15	two	two	CD
cord-022353-q2k2krnm	948	16	inbred	inbred	JJ
cord-022353-q2k2krnm	948	17	and	and	CC
cord-022353-q2k2krnm	948	18	two	two	CD
cord-022353-q2k2krnm	948	19	F1	f1	NN
cord-022353-q2k2krnm	948	20	hybrid	hybrid	NN
cord-022353-q2k2krnm	948	21	strains	strain	NNS
cord-022353-q2k2krnm	948	22	.	.	.
cord-022353-q2k2krnm	949	1	Although	although	IN
cord-022353-q2k2krnm	949	2	widely	widely	RB
cord-022353-q2k2krnm	949	3	distributed	distribute	VBN
cord-022353-q2k2krnm	949	4	,	,	,
cord-022353-q2k2krnm	949	5	ALT	ALT	NNP
cord-022353-q2k2krnm	949	6	is	be	VBZ
cord-022353-q2k2krnm	949	7	mainly	mainly	RB
cord-022353-q2k2krnm	949	8	used	use	VBN
cord-022353-q2k2krnm	949	9	to	to	TO
cord-022353-q2k2krnm	949	10	assess	assess	VB
cord-022353-q2k2krnm	949	11	hepatocellular	hepatocellular	JJ
cord-022353-q2k2krnm	949	12	damage	damage	NN
cord-022353-q2k2krnm	949	13	,	,	,
cord-022353-q2k2krnm	949	14	cardiac	cardiac	JJ
cord-022353-q2k2krnm	949	15	muscle	muscle	NN
cord-022353-q2k2krnm	949	16	damage	damage	NN
cord-022353-q2k2krnm	949	17	(	(	-LRB-
cord-022353-q2k2krnm	949	18	Naraoka	Naraoka	NNP
cord-022353-q2k2krnm	949	19	et	et	NNP
cord-022353-q2k2krnm	949	20	al	al	NNP
cord-022353-q2k2krnm	949	21	.	.	NNP
cord-022353-q2k2krnm	949	22	2005	2005	CD
cord-022353-q2k2krnm	949	23	;	;	:
cord-022353-q2k2krnm	949	24	Ray	Ray	NNP
cord-022353-q2k2krnm	949	25	et	et	NNP
cord-022353-q2k2krnm	949	26	al	al	NNP
cord-022353-q2k2krnm	949	27	.	.	NNP
cord-022353-q2k2krnm	949	28	2005	2005	CD
cord-022353-q2k2krnm	949	29	)	)	-RRB-
cord-022353-q2k2krnm	949	30	,	,	,
cord-022353-q2k2krnm	949	31	and	and	CC
cord-022353-q2k2krnm	949	32	testicular	testicular	JJ
cord-022353-q2k2krnm	949	33	injury	injury	NN
cord-022353-q2k2krnm	950	1	(	(	-LRB-
cord-022353-q2k2krnm	950	2	Santos	Santos	NNP
cord-022353-q2k2krnm	950	3	et	et	NNP
cord-022353-q2k2krnm	950	4	al	al	NNP
cord-022353-q2k2krnm	950	5	.	.	NNP
cord-022353-q2k2krnm	950	6	2005	2005	CD
cord-022353-q2k2krnm	950	7	)	)	-RRB-
cord-022353-q2k2krnm	950	8	.	.	.
cord-022353-q2k2krnm	951	1	ALT	alt	NN
cord-022353-q2k2krnm	951	2	activity	activity	NN
cord-022353-q2k2krnm	951	3	has	have	VBZ
cord-022353-q2k2krnm	951	4	been	be	VBN
cord-022353-q2k2krnm	951	5	used	use	VBN
cord-022353-q2k2krnm	951	6	as	as	IN
cord-022353-q2k2krnm	951	7	an	an	DT
cord-022353-q2k2krnm	951	8	indicator	indicator	NN
cord-022353-q2k2krnm	951	9	of	of	IN
cord-022353-q2k2krnm	951	10	hepatic	hepatic	JJ
cord-022353-q2k2krnm	951	11	injury	injury	NN
cord-022353-q2k2krnm	951	12	of	of	IN
cord-022353-q2k2krnm	951	13	mice	mouse	NNS
cord-022353-q2k2krnm	951	14	infected	infect	VBN
cord-022353-q2k2krnm	951	15	with	with	IN
cord-022353-q2k2krnm	951	16	mouse	mouse	NN
cord-022353-q2k2krnm	951	17	hepatitis	hepatitis	NN
cord-022353-q2k2krnm	951	18	virus	virus	NN
cord-022353-q2k2krnm	951	19	(	(	-LRB-
cord-022353-q2k2krnm	951	20	Fassati	Fassati	NNP
cord-022353-q2k2krnm	951	21	et	et	NNP
cord-022353-q2k2krnm	951	22	al	al	NNP
cord-022353-q2k2krnm	951	23	.	.	NNP
cord-022353-q2k2krnm	951	24	1969	1969	CD
cord-022353-q2k2krnm	951	25	)	)	-RRB-
cord-022353-q2k2krnm	951	26	.	.	.
cord-022353-q2k2krnm	952	1	LDH	LDH	NNP
cord-022353-q2k2krnm	952	2	is	be	VBZ
cord-022353-q2k2krnm	952	3	a	a	DT
cord-022353-q2k2krnm	952	4	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	952	5	enzyme	enzyme	NN
cord-022353-q2k2krnm	952	6	in	in	IN
cord-022353-q2k2krnm	952	7	which	which	WDT
cord-022353-q2k2krnm	952	8	serum	serum	NN
cord-022353-q2k2krnm	952	9	activity	activity	NN
cord-022353-q2k2krnm	952	10	is	be	VBZ
cord-022353-q2k2krnm	952	11	increased	increase	VBN
cord-022353-q2k2krnm	952	12	due	due	IN
cord-022353-q2k2krnm	952	13	to	to	IN
cord-022353-q2k2krnm	952	14	leakage	leakage	VB
cord-022353-q2k2krnm	952	15	across	across	IN
cord-022353-q2k2krnm	952	16	damaged	damage	VBN
cord-022353-q2k2krnm	952	17	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	952	18	membranes	membrane	NNS
cord-022353-q2k2krnm	952	19	.	.	.
cord-022353-q2k2krnm	953	1	LDH	LDH	NNP
cord-022353-q2k2krnm	953	2	reversibly	reversibly	RB
cord-022353-q2k2krnm	953	3	catalyzes	catalyze	VBZ
cord-022353-q2k2krnm	953	4	the	the	DT
cord-022353-q2k2krnm	953	5	conversion	conversion	NN
cord-022353-q2k2krnm	953	6	of	of	IN
cord-022353-q2k2krnm	953	7	pyruvate	pyruvate	NN
cord-022353-q2k2krnm	953	8	to	to	TO
cord-022353-q2k2krnm	953	9	lactate	lactate	VB
cord-022353-q2k2krnm	953	10	.	.	.
cord-022353-q2k2krnm	954	1	Quantification	quantification	NN
cord-022353-q2k2krnm	954	2	of	of	IN
cord-022353-q2k2krnm	954	3	serum	serum	NN
cord-022353-q2k2krnm	954	4	LDH	LDH	NNP
cord-022353-q2k2krnm	954	5	is	be	VBZ
cord-022353-q2k2krnm	954	6	based	base	VBN
cord-022353-q2k2krnm	954	7	on	on	IN
cord-022353-q2k2krnm	954	8	a	a	DT
cord-022353-q2k2krnm	954	9	reaction	reaction	NN
cord-022353-q2k2krnm	954	10	between	between	IN
cord-022353-q2k2krnm	954	11	LDH	LDH	NNP
cord-022353-q2k2krnm	954	12	and	and	CC
cord-022353-q2k2krnm	954	13	a	a	DT
cord-022353-q2k2krnm	954	14	suitable	suitable	JJ
cord-022353-q2k2krnm	954	15	substrate	substrate	NN
cord-022353-q2k2krnm	954	16	(	(	-LRB-
cord-022353-q2k2krnm	954	17	such	such	JJ
cord-022353-q2k2krnm	954	18	as	as	IN
cord-022353-q2k2krnm	954	19	pyruvate	pyruvate	NN
cord-022353-q2k2krnm	954	20	or	or	CC
cord-022353-q2k2krnm	954	21	lactate	lactate	NN
cord-022353-q2k2krnm	954	22	)	)	-RRB-
cord-022353-q2k2krnm	954	23	.	.	.
cord-022353-q2k2krnm	955	1	As	as	IN
cord-022353-q2k2krnm	955	2	in	in	IN
cord-022353-q2k2krnm	955	3	other	other	JJ
cord-022353-q2k2krnm	955	4	species	specie	NNS
cord-022353-q2k2krnm	955	5	,	,	,
cord-022353-q2k2krnm	955	6	LDH	LDH	NNP
cord-022353-q2k2krnm	955	7	in	in	IN
cord-022353-q2k2krnm	955	8	the	the	DT
cord-022353-q2k2krnm	955	9	mouse	mouse	NN
cord-022353-q2k2krnm	955	10	is	be	VBZ
cord-022353-q2k2krnm	955	11	a	a	DT
cord-022353-q2k2krnm	955	12	tetrameric	tetrameric	JJ
cord-022353-q2k2krnm	955	13	enzyme	enzyme	NN
cord-022353-q2k2krnm	955	14	consisting	consist	VBG
cord-022353-q2k2krnm	955	15	of	of	IN
cord-022353-q2k2krnm	955	16	either	either	CC
cord-022353-q2k2krnm	955	17	A	a	NN
cord-022353-q2k2krnm	955	18	or	or	CC
cord-022353-q2k2krnm	955	19	B	b	NN
cord-022353-q2k2krnm	955	20	subunits	subunit	NNS
cord-022353-q2k2krnm	955	21	.	.	.
cord-022353-q2k2krnm	956	1	There	there	EX
cord-022353-q2k2krnm	956	2	are	be	VBP
cord-022353-q2k2krnm	956	3	five	five	CD
cord-022353-q2k2krnm	956	4	isoenzymes	isoenzyme	NNS
cord-022353-q2k2krnm	956	5	of	of	IN
cord-022353-q2k2krnm	956	6	LDH	LDH	NNP
cord-022353-q2k2krnm	956	7	(	(	-LRB-
cord-022353-q2k2krnm	956	8	based	base	VBN
cord-022353-q2k2krnm	956	9	on	on	IN
cord-022353-q2k2krnm	956	10	differences	difference	NNS
cord-022353-q2k2krnm	956	11	subunit	subunit	VBP
cord-022353-q2k2krnm	956	12	A	a	NN
cord-022353-q2k2krnm	956	13	and	and	CC
cord-022353-q2k2krnm	956	14	B	B	NNP
cord-022353-q2k2krnm	956	15	composition	composition	NN
cord-022353-q2k2krnm	956	16	)	)	-RRB-
cord-022353-q2k2krnm	956	17	,	,	,
cord-022353-q2k2krnm	956	18	and	and	CC
cord-022353-q2k2krnm	956	19	these	these	DT
cord-022353-q2k2krnm	956	20	are	be	VBP
cord-022353-q2k2krnm	956	21	LDH-1	LDH-1	NNS
cord-022353-q2k2krnm	956	22	(	(	-LRB-
cord-022353-q2k2krnm	956	23	B4	B4	NNP
cord-022353-q2k2krnm	956	24	)	)	-RRB-
cord-022353-q2k2krnm	956	25	,	,	,
cord-022353-q2k2krnm	956	26	LDH-2	LDH-2	NNP
cord-022353-q2k2krnm	956	27	(	(	-LRB-
cord-022353-q2k2krnm	956	28	A1B3	A1B3	NNP
cord-022353-q2k2krnm	956	29	)	)	-RRB-
cord-022353-q2k2krnm	956	30	,	,	,
cord-022353-q2k2krnm	956	31	LDH-3	LDH-3	NNP
cord-022353-q2k2krnm	956	32	(	(	-LRB-
cord-022353-q2k2krnm	956	33	A2B2	A2B2	NNP
cord-022353-q2k2krnm	956	34	)	)	-RRB-
cord-022353-q2k2krnm	956	35	,	,	,
cord-022353-q2k2krnm	956	36	LDH-4	LDH-4	NNP
cord-022353-q2k2krnm	956	37	(	(	-LRB-
cord-022353-q2k2krnm	956	38	A3B1	A3B1	NNP
cord-022353-q2k2krnm	956	39	)	)	-RRB-
cord-022353-q2k2krnm	956	40	,	,	,
cord-022353-q2k2krnm	956	41	and	and	CC
cord-022353-q2k2krnm	956	42	LDH-5	LDH-5	NNP
cord-022353-q2k2krnm	956	43	(	(	-LRB-
cord-022353-q2k2krnm	956	44	A4	A4	NNP
cord-022353-q2k2krnm	956	45	)	)	-RRB-
cord-022353-q2k2krnm	956	46	.	.	.
cord-022353-q2k2krnm	957	1	Specific	specific	JJ
cord-022353-q2k2krnm	957	2	isoenzyme	isoenzyme	NNS
cord-022353-q2k2krnm	957	3	distribution	distribution	NN
cord-022353-q2k2krnm	957	4	depends	depend	VBZ
cord-022353-q2k2krnm	957	5	on	on	IN
cord-022353-q2k2krnm	957	6	differential	differential	JJ
cord-022353-q2k2krnm	957	7	expression	expression	NN
cord-022353-q2k2krnm	957	8	of	of	IN
cord-022353-q2k2krnm	957	9	either	either	CC
cord-022353-q2k2krnm	957	10	the	the	DT
cord-022353-q2k2krnm	957	11	A	A	NNP
cord-022353-q2k2krnm	957	12	and	and	CC
cord-022353-q2k2krnm	957	13	B	b	NN
cord-022353-q2k2krnm	957	14	subunits	subunit	NNS
cord-022353-q2k2krnm	957	15	(	(	-LRB-
cord-022353-q2k2krnm	957	16	Quimby	Quimby	NNP
cord-022353-q2k2krnm	957	17	1999b	1999b	CD
cord-022353-q2k2krnm	957	18	)	)	-RRB-
cord-022353-q2k2krnm	957	19	.	.	.
cord-022353-q2k2krnm	958	1	For	for	IN
cord-022353-q2k2krnm	958	2	instance	instance	NN
cord-022353-q2k2krnm	958	3	,	,	,
cord-022353-q2k2krnm	958	4	all	all	DT
cord-022353-q2k2krnm	958	5	embryonic	embryonic	JJ
cord-022353-q2k2krnm	958	6	murine	murine	JJ
cord-022353-q2k2krnm	958	7	tissues	tissue	NNS
cord-022353-q2k2krnm	958	8	contain	contain	VBP
cord-022353-q2k2krnm	958	9	LDH-5	LDH-5	NNS
cord-022353-q2k2krnm	958	10	because	because	IN
cord-022353-q2k2krnm	958	11	the	the	DT
cord-022353-q2k2krnm	958	12	A	a	DT
cord-022353-q2k2krnm	958	13	subunit	subunit	NN
cord-022353-q2k2krnm	958	14	is	be	VBZ
cord-022353-q2k2krnm	958	15	only	only	RB
cord-022353-q2k2krnm	958	16	expressed	express	VBN
cord-022353-q2k2krnm	958	17	during	during	IN
cord-022353-q2k2krnm	958	18	early	early	JJ
cord-022353-q2k2krnm	958	19	fetal	fetal	JJ
cord-022353-q2k2krnm	958	20	development	development	NN
cord-022353-q2k2krnm	958	21	.	.	.
cord-022353-q2k2krnm	959	1	As	as	IN
cord-022353-q2k2krnm	959	2	the	the	DT
cord-022353-q2k2krnm	959	3	embryo	embryo	NN
cord-022353-q2k2krnm	959	4	matures	mature	VBZ
cord-022353-q2k2krnm	959	5	,	,	,
cord-022353-q2k2krnm	959	6	subunit	subunit	NN
cord-022353-q2k2krnm	959	7	expression	expression	NN
cord-022353-q2k2krnm	959	8	can	can	MD
cord-022353-q2k2krnm	959	9	involve	involve	VB
cord-022353-q2k2krnm	959	10	both	both	CC
cord-022353-q2k2krnm	959	11	A	a	NN
cord-022353-q2k2krnm	959	12	or	or	CC
cord-022353-q2k2krnm	959	13	B	b	NN
cord-022353-q2k2krnm	959	14	subunits	subunit	NNS
cord-022353-q2k2krnm	959	15	in	in	IN
cord-022353-q2k2krnm	959	16	different	different	JJ
cord-022353-q2k2krnm	959	17	tissues	tissue	NNS
cord-022353-q2k2krnm	959	18	,	,	,
cord-022353-q2k2krnm	959	19	meaning	mean	VBG
cord-022353-q2k2krnm	959	20	that	that	IN
cord-022353-q2k2krnm	959	21	by	by	IN
cord-022353-q2k2krnm	959	22	birth	birth	NN
cord-022353-q2k2krnm	959	23	and	and	CC
cord-022353-q2k2krnm	959	24	sexual	sexual	JJ
cord-022353-q2k2krnm	959	25	maturity	maturity	NN
cord-022353-q2k2krnm	959	26	,	,	,
cord-022353-q2k2krnm	959	27	each	each	DT
cord-022353-q2k2krnm	959	28	tissue	tissue	NN
cord-022353-q2k2krnm	959	29	contain	contain	VBP
cord-022353-q2k2krnm	959	30	a	a	DT
cord-022353-q2k2krnm	959	31	characteristic	characteristic	JJ
cord-022353-q2k2krnm	959	32	LDH	LDH	NNP
cord-022353-q2k2krnm	959	33	subunit	subunit	NN
cord-022353-q2k2krnm	959	34	profile	profile	NN
cord-022353-q2k2krnm	959	35	.	.	.
cord-022353-q2k2krnm	960	1	In	in	IN
cord-022353-q2k2krnm	960	2	adult	adult	NN
cord-022353-q2k2krnm	960	3	mice	mouse	NNS
cord-022353-q2k2krnm	960	4	,	,	,
cord-022353-q2k2krnm	960	5	the	the	DT
cord-022353-q2k2krnm	960	6	heart	heart	NN
cord-022353-q2k2krnm	960	7	and	and	CC
cord-022353-q2k2krnm	960	8	erythrocytes	erythrocyte	NNS
cord-022353-q2k2krnm	960	9	contain	contain	VBP
cord-022353-q2k2krnm	960	10	LDH-1	LDH-1	NNS
cord-022353-q2k2krnm	960	11	and	and	CC
cord-022353-q2k2krnm	960	12	LDH-2	LDH-2	NNP
cord-022353-q2k2krnm	960	13	,	,	,
cord-022353-q2k2krnm	960	14	whereas	whereas	IN
cord-022353-q2k2krnm	960	15	most	most	JJS
cord-022353-q2k2krnm	960	16	other	other	JJ
cord-022353-q2k2krnm	960	17	tissues	tissue	NNS
cord-022353-q2k2krnm	960	18	have	have	VBP
cord-022353-q2k2krnm	960	19	LDH-3	LDH-3	NNPS
cord-022353-q2k2krnm	960	20	.	.	.
cord-022353-q2k2krnm	961	1	Skeletal	skeletal	JJ
cord-022353-q2k2krnm	961	2	muscle	muscle	NN
cord-022353-q2k2krnm	961	3	and	and	CC
cord-022353-q2k2krnm	961	4	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	961	5	fail	fail	VBP
cord-022353-q2k2krnm	961	6	to	to	TO
cord-022353-q2k2krnm	961	7	express	express	VB
cord-022353-q2k2krnm	961	8	subunit	subunit	NN
cord-022353-q2k2krnm	961	9	B	b	NN
cord-022353-q2k2krnm	961	10	and	and	CC
cord-022353-q2k2krnm	961	11	therefore	therefore	RB
cord-022353-q2k2krnm	961	12	are	be	VBP
cord-022353-q2k2krnm	961	13	composed	compose	VBN
cord-022353-q2k2krnm	961	14	predominantly	predominantly	RB
cord-022353-q2k2krnm	961	15	of	of	IN
cord-022353-q2k2krnm	961	16	LDH-5	LDH-5	NNP
cord-022353-q2k2krnm	961	17	.	.	.
cord-022353-q2k2krnm	962	1	Serum	serum	NN
cord-022353-q2k2krnm	962	2	LDH	LDH	NNP
cord-022353-q2k2krnm	962	3	activity	activity	NN
cord-022353-q2k2krnm	962	4	can	can	MD
cord-022353-q2k2krnm	962	5	vary	vary	VB
cord-022353-q2k2krnm	962	6	due	due	IN
cord-022353-q2k2krnm	962	7	to	to	IN
cord-022353-q2k2krnm	962	8	age	age	NN
cord-022353-q2k2krnm	962	9	and	and	CC
cord-022353-q2k2krnm	962	10	sex	sex	NN
cord-022353-q2k2krnm	962	11	.	.	.
cord-022353-q2k2krnm	963	1	LDH	LDH	NNP
cord-022353-q2k2krnm	963	2	levels	level	NNS
cord-022353-q2k2krnm	963	3	have	have	VBP
cord-022353-q2k2krnm	963	4	been	be	VBN
cord-022353-q2k2krnm	963	5	shown	show	VBN
cord-022353-q2k2krnm	963	6	to	to	TO
cord-022353-q2k2krnm	963	7	be	be	VB
cord-022353-q2k2krnm	963	8	higher	high	JJR
cord-022353-q2k2krnm	963	9	in	in	IN
cord-022353-q2k2krnm	963	10	males	male	NNS
cord-022353-q2k2krnm	963	11	versus	versus	IN
cord-022353-q2k2krnm	963	12	females	female	NNS
cord-022353-q2k2krnm	963	13	of	of	IN
cord-022353-q2k2krnm	963	14	the	the	DT
cord-022353-q2k2krnm	963	15	BALB	BALB	NNP
cord-022353-q2k2krnm	963	16	/	/	SYM
cord-022353-q2k2krnm	963	17	c	c	NN
cord-022353-q2k2krnm	963	18	strain	strain	NN
cord-022353-q2k2krnm	964	1	(	(	-LRB-
cord-022353-q2k2krnm	964	2	Frith	Frith	NNP
cord-022353-q2k2krnm	964	3	et	et	NNP
cord-022353-q2k2krnm	964	4	al	al	NNP
cord-022353-q2k2krnm	964	5	.	.	.
cord-022353-q2k2krnm	964	6	1980	1980	CD
cord-022353-q2k2krnm	964	7	)	)	-RRB-
cord-022353-q2k2krnm	964	8	.	.	.
cord-022353-q2k2krnm	965	1	Serum	serum	NN
cord-022353-q2k2krnm	965	2	LDH	LDH	NNP
cord-022353-q2k2krnm	965	3	levels	level	NNS
cord-022353-q2k2krnm	965	4	increase	increase	VBP
cord-022353-q2k2krnm	965	5	with	with	IN
cord-022353-q2k2krnm	965	6	age	age	NN
cord-022353-q2k2krnm	965	7	in	in	IN
cord-022353-q2k2krnm	965	8	BALB	BALB	NNP
cord-022353-q2k2krnm	965	9	/	/	SYM
cord-022353-q2k2krnm	965	10	c	c	NN
cord-022353-q2k2krnm	965	11	and	and	CC
cord-022353-q2k2krnm	965	12	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	965	13	mice	mouse	NNS
cord-022353-q2k2krnm	965	14	of	of	IN
cord-022353-q2k2krnm	965	15	both	both	DT
cord-022353-q2k2krnm	965	16	sexes	sex	NNS
cord-022353-q2k2krnm	966	1	(	(	-LRB-
cord-022353-q2k2krnm	966	2	Frith	Frith	NNP
cord-022353-q2k2krnm	966	3	et	et	NNP
cord-022353-q2k2krnm	966	4	al	al	NNP
cord-022353-q2k2krnm	966	5	.	.	.
cord-022353-q2k2krnm	966	6	1980	1980	CD
cord-022353-q2k2krnm	966	7	)	)	-RRB-
cord-022353-q2k2krnm	966	8	.	.	.
cord-022353-q2k2krnm	967	1	Serum	serum	NN
cord-022353-q2k2krnm	967	2	LDH	LDH	NNP
cord-022353-q2k2krnm	967	3	can	can	MD
cord-022353-q2k2krnm	967	4	also	also	RB
cord-022353-q2k2krnm	967	5	be	be	VB
cord-022353-q2k2krnm	967	6	elevated	elevate	VBN
cord-022353-q2k2krnm	967	7	falsely	falsely	RB
cord-022353-q2k2krnm	967	8	by	by	IN
cord-022353-q2k2krnm	967	9	hemolysis	hemolysis	NN
cord-022353-q2k2krnm	967	10	.	.	.
cord-022353-q2k2krnm	968	1	Quantification	quantification	NN
cord-022353-q2k2krnm	968	2	of	of	IN
cord-022353-q2k2krnm	968	3	serum	serum	NN
cord-022353-q2k2krnm	968	4	LDH	LDH	NNP
cord-022353-q2k2krnm	968	5	measures	measure	VBZ
cord-022353-q2k2krnm	968	6	the	the	DT
cord-022353-q2k2krnm	968	7	total	total	JJ
cord-022353-q2k2krnm	968	8	LDH	LDH	NNP
cord-022353-q2k2krnm	968	9	activity	activity	NN
cord-022353-q2k2krnm	968	10	from	from	IN
cord-022353-q2k2krnm	968	11	all	all	DT
cord-022353-q2k2krnm	968	12	sources	source	NNS
cord-022353-q2k2krnm	968	13	.	.	.
cord-022353-q2k2krnm	969	1	However	however	RB
cord-022353-q2k2krnm	969	2	,	,	,
cord-022353-q2k2krnm	969	3	damage	damage	NN
cord-022353-q2k2krnm	969	4	to	to	IN
cord-022353-q2k2krnm	969	5	a	a	DT
cord-022353-q2k2krnm	969	6	particular	particular	JJ
cord-022353-q2k2krnm	969	7	tissue	tissue	NN
cord-022353-q2k2krnm	969	8	will	will	MD
cord-022353-q2k2krnm	969	9	result	result	VB
cord-022353-q2k2krnm	969	10	in	in	IN
cord-022353-q2k2krnm	969	11	increased	increase	VBN
cord-022353-q2k2krnm	969	12	activity	activity	NN
cord-022353-q2k2krnm	969	13	of	of	IN
cord-022353-q2k2krnm	969	14	that	that	DT
cord-022353-q2k2krnm	969	15	isoenzyme	isoenzyme	NNS
cord-022353-q2k2krnm	969	16	in	in	IN
cord-022353-q2k2krnm	969	17	serum	serum	NN
cord-022353-q2k2krnm	969	18	.	.	.
cord-022353-q2k2krnm	970	1	In	in	IN
cord-022353-q2k2krnm	970	2	general	general	JJ
cord-022353-q2k2krnm	970	3	,	,	,
cord-022353-q2k2krnm	970	4	the	the	DT
cord-022353-q2k2krnm	970	5	highest	high	JJS
cord-022353-q2k2krnm	970	6	activity	activity	NN
cord-022353-q2k2krnm	970	7	of	of	IN
cord-022353-q2k2krnm	970	8	LDH	LDH	NNP
cord-022353-q2k2krnm	970	9	in	in	IN
cord-022353-q2k2krnm	970	10	the	the	DT
cord-022353-q2k2krnm	970	11	mouse	mouse	NN
cord-022353-q2k2krnm	970	12	is	be	VBZ
cord-022353-q2k2krnm	970	13	in	in	IN
cord-022353-q2k2krnm	970	14	skeletal	skeletal	JJ
cord-022353-q2k2krnm	970	15	muscle	muscle	NN
cord-022353-q2k2krnm	970	16	,	,	,
cord-022353-q2k2krnm	970	17	with	with	IN
cord-022353-q2k2krnm	970	18	decreasing	decrease	VBG
cord-022353-q2k2krnm	970	19	activity	activity	NN
cord-022353-q2k2krnm	970	20	in	in	IN
cord-022353-q2k2krnm	970	21	the	the	DT
cord-022353-q2k2krnm	970	22	heart	heart	NN
cord-022353-q2k2krnm	970	23	,	,	,
cord-022353-q2k2krnm	970	24	liver	liver	NN
cord-022353-q2k2krnm	970	25	,	,	,
cord-022353-q2k2krnm	970	26	kidney	kidney	NN
cord-022353-q2k2krnm	970	27	,	,	,
cord-022353-q2k2krnm	970	28	and	and	CC
cord-022353-q2k2krnm	970	29	intestine	intestine	NN
cord-022353-q2k2krnm	970	30	.	.	.
cord-022353-q2k2krnm	971	1	Serum	serum	NN
cord-022353-q2k2krnm	971	2	LDH-5	LDH-5	NNP
cord-022353-q2k2krnm	971	3	activity	activity	NN
cord-022353-q2k2krnm	971	4	rises	rise	VBZ
cord-022353-q2k2krnm	971	5	within	within	IN
cord-022353-q2k2krnm	971	6	72	72	CD
cord-022353-q2k2krnm	971	7	h	h	NN
cord-022353-q2k2krnm	971	8	after	after	IN
cord-022353-q2k2krnm	971	9	inoculating	inoculate	VBG
cord-022353-q2k2krnm	971	10	mice	mouse	NNS
cord-022353-q2k2krnm	971	11	with	with	IN
cord-022353-q2k2krnm	971	12	the	the	DT
cord-022353-q2k2krnm	971	13	mouse	mouse	NN
cord-022353-q2k2krnm	971	14	hepatitis	hepatitis	NN
cord-022353-q2k2krnm	971	15	virus	virus	NN
cord-022353-q2k2krnm	971	16	(	(	-LRB-
cord-022353-q2k2krnm	971	17	Fassati	Fassati	NNP
cord-022353-q2k2krnm	971	18	et	et	NNP
cord-022353-q2k2krnm	971	19	al	al	NNP
cord-022353-q2k2krnm	971	20	.	.	NNP
cord-022353-q2k2krnm	971	21	1969	1969	CD
cord-022353-q2k2krnm	971	22	)	)	-RRB-
cord-022353-q2k2krnm	971	23	.	.	.
cord-022353-q2k2krnm	972	1	Mice	mouse	NNS
cord-022353-q2k2krnm	972	2	infected	infect	VBN
cord-022353-q2k2krnm	972	3	with	with	IN
cord-022353-q2k2krnm	972	4	the	the	DT
cord-022353-q2k2krnm	972	5	LDH	LDH	NNP
cord-022353-q2k2krnm	972	6	virus	virus	NN
cord-022353-q2k2krnm	973	1	(	(	-LRB-
cord-022353-q2k2krnm	973	2	LDV	LDV	NNP
cord-022353-q2k2krnm	973	3	)	)	-RRB-
cord-022353-q2k2krnm	973	4	exhibit	exhibit	NN
cord-022353-q2k2krnm	973	5	increased	increase	VBN
cord-022353-q2k2krnm	973	6	serum	serum	NN
cord-022353-q2k2krnm	973	7	concentrations	concentration	NNS
cord-022353-q2k2krnm	973	8	of	of	IN
cord-022353-q2k2krnm	973	9	LDH	LDH	NNP
cord-022353-q2k2krnm	973	10	,	,	,
cord-022353-q2k2krnm	973	11	isocitric	isocitric	JJ
cord-022353-q2k2krnm	973	12	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	973	13	,	,	,
cord-022353-q2k2krnm	973	14	malic	malic	JJ
cord-022353-q2k2krnm	973	15	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	973	16	,	,	,
cord-022353-q2k2krnm	973	17	phosphohexase	phosphohexase	NN
cord-022353-q2k2krnm	973	18	isomerase	isomerase	NN
cord-022353-q2k2krnm	973	19	,	,	,
cord-022353-q2k2krnm	973	20	and	and	CC
cord-022353-q2k2krnm	973	21	AST	AST	NNP
cord-022353-q2k2krnm	973	22	(	(	-LRB-
cord-022353-q2k2krnm	973	23	Notkins	Notkins	NNP
cord-022353-q2k2krnm	973	24	1965	1965	CD
cord-022353-q2k2krnm	973	25	)	)	-RRB-
cord-022353-q2k2krnm	973	26	.	.	.
cord-022353-q2k2krnm	974	1	Along	along	IN
cord-022353-q2k2krnm	974	2	with	with	IN
cord-022353-q2k2krnm	974	3	AST	AST	NNP
cord-022353-q2k2krnm	974	4	and	and	CC
cord-022353-q2k2krnm	974	5	CK	CK	NNP
cord-022353-q2k2krnm	974	6	,	,	,
cord-022353-q2k2krnm	974	7	LDH	LDH	NNP
cord-022353-q2k2krnm	974	8	is	be	VBZ
cord-022353-q2k2krnm	974	9	considered	consider	VBN
cord-022353-q2k2krnm	974	10	an	an	DT
cord-022353-q2k2krnm	974	11	excellent	excellent	JJ
cord-022353-q2k2krnm	974	12	marker	marker	NN
cord-022353-q2k2krnm	974	13	for	for	IN
cord-022353-q2k2krnm	974	14	cardiac	cardiac	JJ
cord-022353-q2k2krnm	974	15	injury	injury	NN
cord-022353-q2k2krnm	975	1	(	(	-LRB-
cord-022353-q2k2krnm	975	2	Naraoka	Naraoka	NNP
cord-022353-q2k2krnm	975	3	et	et	NNP
cord-022353-q2k2krnm	975	4	al	al	NNP
cord-022353-q2k2krnm	975	5	.	.	.
cord-022353-q2k2krnm	976	1	2005	2005	CD
cord-022353-q2k2krnm	976	2	;	;	:
cord-022353-q2k2krnm	976	3	Ray	Ray	NNP
cord-022353-q2k2krnm	976	4	et	et	NNP
cord-022353-q2k2krnm	976	5	al	al	NNP
cord-022353-q2k2krnm	976	6	.	.	NNP
cord-022353-q2k2krnm	976	7	2005	2005	CD
cord-022353-q2k2krnm	976	8	)	)	-RRB-
cord-022353-q2k2krnm	976	9	.	.	.
cord-022353-q2k2krnm	977	1	OTC	OTC	NNP
cord-022353-q2k2krnm	977	2	is	be	VBZ
cord-022353-q2k2krnm	977	3	a	a	DT
cord-022353-q2k2krnm	977	4	mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	977	5	enzyme	enzyme	NN
cord-022353-q2k2krnm	977	6	in	in	IN
cord-022353-q2k2krnm	977	7	which	which	WDT
cord-022353-q2k2krnm	977	8	serum	serum	NN
cord-022353-q2k2krnm	977	9	activity	activity	NN
cord-022353-q2k2krnm	977	10	is	be	VBZ
cord-022353-q2k2krnm	977	11	increased	increase	VBN
cord-022353-q2k2krnm	977	12	due	due	IN
cord-022353-q2k2krnm	977	13	to	to	IN
cord-022353-q2k2krnm	977	14	leakage	leakage	VB
cord-022353-q2k2krnm	977	15	across	across	IN
cord-022353-q2k2krnm	977	16	damaged	damage	VBN
cord-022353-q2k2krnm	977	17	mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	977	18	membranes	membrane	NNS
cord-022353-q2k2krnm	977	19	.	.	.
cord-022353-q2k2krnm	978	1	OTC	OTC	NNP
cord-022353-q2k2krnm	978	2	is	be	VBZ
cord-022353-q2k2krnm	978	3	found	find	VBN
cord-022353-q2k2krnm	978	4	primarily	primarily	RB
cord-022353-q2k2krnm	978	5	in	in	IN
cord-022353-q2k2krnm	978	6	the	the	DT
cord-022353-q2k2krnm	978	7	liver	liver	NN
cord-022353-q2k2krnm	978	8	of	of	IN
cord-022353-q2k2krnm	978	9	mice	mouse	NNS
cord-022353-q2k2krnm	978	10	,	,	,
cord-022353-q2k2krnm	978	11	and	and	CC
cord-022353-q2k2krnm	978	12	there	there	EX
cord-022353-q2k2krnm	978	13	increases	increase	NNS
cord-022353-q2k2krnm	978	14	in	in	IN
cord-022353-q2k2krnm	978	15	serum	serum	NN
cord-022353-q2k2krnm	978	16	activity	activity	NN
cord-022353-q2k2krnm	978	17	reflect	reflect	VBP
cord-022353-q2k2krnm	978	18	severe	severe	JJ
cord-022353-q2k2krnm	978	19	injury	injury	NN
cord-022353-q2k2krnm	978	20	to	to	IN
cord-022353-q2k2krnm	978	21	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	978	22	.	.	.
cord-022353-q2k2krnm	979	1	Abnormal	abnormal	JJ
cord-022353-q2k2krnm	979	2	OTC	OTC	NNP
cord-022353-q2k2krnm	979	3	activity	activity	NN
cord-022353-q2k2krnm	979	4	has	have	VBZ
cord-022353-q2k2krnm	979	5	been	be	VBN
cord-022353-q2k2krnm	979	6	described	describe	VBN
cord-022353-q2k2krnm	979	7	in	in	IN
cord-022353-q2k2krnm	979	8	mice	mouse	NNS
cord-022353-q2k2krnm	979	9	having	have	VBG
cord-022353-q2k2krnm	979	10	the	the	DT
cord-022353-q2k2krnm	979	11	sparse	sparse	JJ
cord-022353-q2k2krnm	979	12	-	-	HYPH
cord-022353-q2k2krnm	979	13	fur	fur	NN
cord-022353-q2k2krnm	979	14	(	(	-LRB-
cord-022353-q2k2krnm	979	15	spf	spf	NNP
cord-022353-q2k2krnm	979	16	/	/	SYM
cord-022353-q2k2krnm	979	17	Y	Y	NNP
cord-022353-q2k2krnm	979	18	)	)	-RRB-
cord-022353-q2k2krnm	979	19	mutation	mutation	NN
cord-022353-q2k2krnm	979	20	.	.	.
cord-022353-q2k2krnm	980	1	They	-PRON-	PRP
cord-022353-q2k2krnm	980	2	serve	serve	VBP
cord-022353-q2k2krnm	980	3	as	as	IN
cord-022353-q2k2krnm	980	4	a	a	DT
cord-022353-q2k2krnm	980	5	model	model	NN
cord-022353-q2k2krnm	980	6	for	for	IN
cord-022353-q2k2krnm	980	7	the	the	DT
cord-022353-q2k2krnm	980	8	most	most	RBS
cord-022353-q2k2krnm	980	9	common	common	JJ
cord-022353-q2k2krnm	980	10	inborn	inborn	JJ
cord-022353-q2k2krnm	980	11	error	error	NN
cord-022353-q2k2krnm	980	12	of	of	IN
cord-022353-q2k2krnm	980	13	urea	urea	NN
cord-022353-q2k2krnm	980	14	synthesis	synthesis	NN
cord-022353-q2k2krnm	980	15	in	in	IN
cord-022353-q2k2krnm	980	16	humans	human	NNS
cord-022353-q2k2krnm	980	17	.	.	.
cord-022353-q2k2krnm	981	1	Assays	assay	NNS
cord-022353-q2k2krnm	981	2	for	for	IN
cord-022353-q2k2krnm	981	3	mouse	mouse	NN
cord-022353-q2k2krnm	981	4	OTC	OTC	NNP
cord-022353-q2k2krnm	981	5	have	have	VBP
cord-022353-q2k2krnm	981	6	been	be	VBN
cord-022353-q2k2krnm	981	7	developed	develop	VBN
cord-022353-q2k2krnm	981	8	to	to	TO
cord-022353-q2k2krnm	981	9	monitor	monitor	VB
cord-022353-q2k2krnm	981	10	activity	activity	NN
cord-022353-q2k2krnm	981	11	levels	level	NNS
cord-022353-q2k2krnm	981	12	following	follow	VBG
cord-022353-q2k2krnm	981	13	gene	gene	NN
cord-022353-q2k2krnm	981	14	transfer	transfer	NN
cord-022353-q2k2krnm	981	15	or	or	CC
cord-022353-q2k2krnm	981	16	liver	liver	NN
cord-022353-q2k2krnm	981	17	transplantation	transplantation	NN
cord-022353-q2k2krnm	981	18	(	(	-LRB-
cord-022353-q2k2krnm	981	19	Batshaw	Batshaw	NNP
cord-022353-q2k2krnm	981	20	et	et	NNP
cord-022353-q2k2krnm	981	21	al	al	NNP
cord-022353-q2k2krnm	981	22	.	.	.
cord-022353-q2k2krnm	982	1	1999	1999	CD
cord-022353-q2k2krnm	982	2	;	;	:
cord-022353-q2k2krnm	982	3	Ye	Ye	NNP
cord-022353-q2k2krnm	982	4	et	et	NNP
cord-022353-q2k2krnm	982	5	al	al	NNP
cord-022353-q2k2krnm	982	6	.	.	NNP
cord-022353-q2k2krnm	982	7	2001	2001	CD
cord-022353-q2k2krnm	982	8	)	)	-RRB-
cord-022353-q2k2krnm	982	9	.	.	.
cord-022353-q2k2krnm	983	1	CK	CK	NNP
cord-022353-q2k2krnm	983	2	is	be	VBZ
cord-022353-q2k2krnm	983	3	a	a	DT
cord-022353-q2k2krnm	983	4	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	983	5	and	and	CC
cord-022353-q2k2krnm	983	6	mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	983	7	enzyme	enzyme	NN
cord-022353-q2k2krnm	983	8	in	in	IN
cord-022353-q2k2krnm	983	9	which	which	WDT
cord-022353-q2k2krnm	983	10	serum	serum	NN
cord-022353-q2k2krnm	983	11	activity	activity	NN
cord-022353-q2k2krnm	983	12	is	be	VBZ
cord-022353-q2k2krnm	983	13	increased	increase	VBN
cord-022353-q2k2krnm	983	14	due	due	IN
cord-022353-q2k2krnm	983	15	to	to	IN
cord-022353-q2k2krnm	983	16	leakage	leakage	VB
cord-022353-q2k2krnm	983	17	across	across	IN
cord-022353-q2k2krnm	983	18	damaged	damage	VBN
cord-022353-q2k2krnm	983	19	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	983	20	and	and	CC
cord-022353-q2k2krnm	983	21	mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	983	22	membranes	membrane	NNS
cord-022353-q2k2krnm	983	23	.	.	.
cord-022353-q2k2krnm	984	1	CK	CK	NNP
cord-022353-q2k2krnm	984	2	reversibly	reversibly	RB
cord-022353-q2k2krnm	984	3	catalyzes	catalyze	VBZ
cord-022353-q2k2krnm	984	4	the	the	DT
cord-022353-q2k2krnm	984	5	phosphorylation	phosphorylation	NN
cord-022353-q2k2krnm	984	6	of	of	IN
cord-022353-q2k2krnm	984	7	adenosine	adenosine	NN
cord-022353-q2k2krnm	984	8	diphosphate	diphosphate	NN
cord-022353-q2k2krnm	984	9	(	(	-LRB-
cord-022353-q2k2krnm	984	10	ADP	ADP	NNP
cord-022353-q2k2krnm	984	11	)	)	-RRB-
cord-022353-q2k2krnm	984	12	to	to	TO
cord-022353-q2k2krnm	984	13	ATE	ate	VB
cord-022353-q2k2krnm	984	14	using	use	VBG
cord-022353-q2k2krnm	984	15	creatine	creatine	NN
cord-022353-q2k2krnm	984	16	phosphate	phosphate	NN
cord-022353-q2k2krnm	984	17	as	as	IN
cord-022353-q2k2krnm	984	18	the	the	DT
cord-022353-q2k2krnm	984	19	donor	donor	NN
cord-022353-q2k2krnm	984	20	for	for	IN
cord-022353-q2k2krnm	984	21	the	the	DT
cord-022353-q2k2krnm	984	22	phosphate	phosphate	NN
cord-022353-q2k2krnm	984	23	group	group	NN
cord-022353-q2k2krnm	984	24	.	.	.
cord-022353-q2k2krnm	985	1	Quantification	quantification	NN
cord-022353-q2k2krnm	985	2	of	of	IN
cord-022353-q2k2krnm	985	3	serum	serum	NN
cord-022353-q2k2krnm	985	4	CK	CK	NNP
cord-022353-q2k2krnm	985	5	is	be	VBZ
cord-022353-q2k2krnm	985	6	based	base	VBN
cord-022353-q2k2krnm	985	7	on	on	IN
cord-022353-q2k2krnm	985	8	a	a	DT
cord-022353-q2k2krnm	985	9	reaction	reaction	NN
cord-022353-q2k2krnm	985	10	between	between	IN
cord-022353-q2k2krnm	985	11	CK	CK	NNP
cord-022353-q2k2krnm	985	12	and	and	CC
cord-022353-q2k2krnm	985	13	a	a	DT
cord-022353-q2k2krnm	985	14	suitable	suitable	JJ
cord-022353-q2k2krnm	985	15	substrate	substrate	NN
cord-022353-q2k2krnm	985	16	(	(	-LRB-
cord-022353-q2k2krnm	985	17	such	such	JJ
cord-022353-q2k2krnm	985	18	as	as	IN
cord-022353-q2k2krnm	985	19	creatine	creatine	NN
cord-022353-q2k2krnm	985	20	phosphate	phosphate	NN
cord-022353-q2k2krnm	985	21	)	)	-RRB-
cord-022353-q2k2krnm	985	22	.	.	.
cord-022353-q2k2krnm	986	1	As	as	IN
cord-022353-q2k2krnm	986	2	in	in	IN
cord-022353-q2k2krnm	986	3	other	other	JJ
cord-022353-q2k2krnm	986	4	species	specie	NNS
cord-022353-q2k2krnm	986	5	,	,	,
cord-022353-q2k2krnm	986	6	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	986	7	CK	CK	NNP
cord-022353-q2k2krnm	986	8	is	be	VBZ
cord-022353-q2k2krnm	986	9	a	a	DT
cord-022353-q2k2krnm	986	10	dimeric	dimeric	JJ
cord-022353-q2k2krnm	986	11	enzyme	enzyme	NN
cord-022353-q2k2krnm	986	12	consisting	consist	VBG
cord-022353-q2k2krnm	986	13	of	of	IN
cord-022353-q2k2krnm	986	14	either	either	DT
cord-022353-q2k2krnm	986	15	M	M	NNP
cord-022353-q2k2krnm	986	16	or	or	CC
cord-022353-q2k2krnm	986	17	B	B	NNP
cord-022353-q2k2krnm	986	18	subunits	subunit	NNS
cord-022353-q2k2krnm	986	19	.	.	.
cord-022353-q2k2krnm	987	1	There	there	EX
cord-022353-q2k2krnm	987	2	are	be	VBP
cord-022353-q2k2krnm	987	3	three	three	CD
cord-022353-q2k2krnm	987	4	isoenzymes	isoenzyme	NNS
cord-022353-q2k2krnm	987	5	of	of	IN
cord-022353-q2k2krnm	987	6	CK	CK	NNP
cord-022353-q2k2krnm	987	7	(	(	-LRB-
cord-022353-q2k2krnm	987	8	based	base	VBN
cord-022353-q2k2krnm	987	9	on	on	IN
cord-022353-q2k2krnm	987	10	differences	difference	NNS
cord-022353-q2k2krnm	987	11	subunit	subunit	NN
cord-022353-q2k2krnm	987	12	M	M	NNP
cord-022353-q2k2krnm	987	13	and	and	CC
cord-022353-q2k2krnm	987	14	B	B	NNP
cord-022353-q2k2krnm	987	15	composition	composition	NN
cord-022353-q2k2krnm	987	16	)	)	-RRB-
cord-022353-q2k2krnm	987	17	,	,	,
cord-022353-q2k2krnm	987	18	and	and	CC
cord-022353-q2k2krnm	987	19	these	these	DT
cord-022353-q2k2krnm	987	20	are	be	VBP
cord-022353-q2k2krnm	987	21	CK-1	CK-1	NNP
cord-022353-q2k2krnm	987	22	(	(	-LRB-
cord-022353-q2k2krnm	987	23	BB	BB	NNP
cord-022353-q2k2krnm	987	24	)	)	-RRB-
cord-022353-q2k2krnm	987	25	,	,	,
cord-022353-q2k2krnm	987	26	CK-2	CK-2	NNP
cord-022353-q2k2krnm	987	27	(	(	-LRB-
cord-022353-q2k2krnm	987	28	MB	MB	NNP
cord-022353-q2k2krnm	987	29	)	)	-RRB-
cord-022353-q2k2krnm	987	30	,	,	,
cord-022353-q2k2krnm	987	31	and	and	CC
cord-022353-q2k2krnm	987	32	CK-3	CK-3	NNP
cord-022353-q2k2krnm	987	33	(	(	-LRB-
cord-022353-q2k2krnm	987	34	MM	MM	NNP
cord-022353-q2k2krnm	987	35	)	)	-RRB-
cord-022353-q2k2krnm	987	36	.	.	.
cord-022353-q2k2krnm	988	1	Brain	brain	NN
cord-022353-q2k2krnm	988	2	contains	contain	VBZ
cord-022353-q2k2krnm	988	3	CK-1	CK-1	NNP
cord-022353-q2k2krnm	988	4	,	,	,
cord-022353-q2k2krnm	988	5	skeletal	skeletal	JJ
cord-022353-q2k2krnm	988	6	muscle	muscle	NN
cord-022353-q2k2krnm	988	7	contains	contain	VBZ
cord-022353-q2k2krnm	988	8	CK-3	CK-3	NNP
cord-022353-q2k2krnm	988	9	(	(	-LRB-
cord-022353-q2k2krnm	988	10	MM	MM	NNP
cord-022353-q2k2krnm	988	11	)	)	-RRB-
cord-022353-q2k2krnm	988	12	,	,	,
cord-022353-q2k2krnm	988	13	and	and	CC
cord-022353-q2k2krnm	988	14	cardiac	cardiac	JJ
cord-022353-q2k2krnm	988	15	muscle	muscle	NN
cord-022353-q2k2krnm	988	16	contains	contain	VBZ
cord-022353-q2k2krnm	988	17	CK-1	CK-1	NNP
cord-022353-q2k2krnm	988	18	,	,	,
cord-022353-q2k2krnm	988	19	CK-3	CK-3	NNP
cord-022353-q2k2krnm	988	20	,	,	,
cord-022353-q2k2krnm	988	21	and	and	CC
cord-022353-q2k2krnm	989	1	CK-2	CK-2	NNP
cord-022353-q2k2krnm	989	2	(	(	-LRB-
cord-022353-q2k2krnm	989	3	MB	MB	NNP
cord-022353-q2k2krnm	989	4	)	)	-RRB-
cord-022353-q2k2krnm	989	5	(	(	-LRB-
cord-022353-q2k2krnm	989	6	Quimby	Quimby	NNP
cord-022353-q2k2krnm	989	7	1999b	1999b	CD
cord-022353-q2k2krnm	989	8	)	)	-RRB-
cord-022353-q2k2krnm	989	9	.	.	.
cord-022353-q2k2krnm	990	1	In	in	IN
cord-022353-q2k2krnm	990	2	the	the	DT
cord-022353-q2k2krnm	990	3	mouse	mouse	NN
cord-022353-q2k2krnm	990	4	,	,	,
cord-022353-q2k2krnm	990	5	the	the	DT
cord-022353-q2k2krnm	990	6	greatest	great	JJS
cord-022353-q2k2krnm	990	7	CK	CK	NNP
cord-022353-q2k2krnm	990	8	activity	activity	NN
cord-022353-q2k2krnm	990	9	is	be	VBZ
cord-022353-q2k2krnm	990	10	found	find	VBN
cord-022353-q2k2krnm	990	11	in	in	IN
cord-022353-q2k2krnm	990	12	skeletal	skeletal	JJ
cord-022353-q2k2krnm	990	13	muscle	muscle	NN
cord-022353-q2k2krnm	990	14	,	,	,
cord-022353-q2k2krnm	990	15	with	with	IN
cord-022353-q2k2krnm	990	16	much	much	RB
cord-022353-q2k2krnm	990	17	less	less	JJR
cord-022353-q2k2krnm	990	18	activity	activity	NN
cord-022353-q2k2krnm	990	19	found	find	VBN
cord-022353-q2k2krnm	990	20	in	in	IN
cord-022353-q2k2krnm	990	21	the	the	DT
cord-022353-q2k2krnm	990	22	heart	heart	NN
cord-022353-q2k2krnm	990	23	and	and	CC
cord-022353-q2k2krnm	990	24	brain	brain	NN
cord-022353-q2k2krnm	990	25	.	.	.
cord-022353-q2k2krnm	991	1	Mitochondrial	mitochondrial	NN
cord-022353-q2k2krnm	991	2	CK	CK	NNP
cord-022353-q2k2krnm	991	3	(	(	-LRB-
cord-022353-q2k2krnm	991	4	CK	CK	NNP
cord-022353-q2k2krnm	991	5	-	-	HYPH
cord-022353-q2k2krnm	991	6	Mt	Mt	NNP
cord-022353-q2k2krnm	991	7	)	)	-RRB-
cord-022353-q2k2krnm	991	8	is	be	VBZ
cord-022353-q2k2krnm	991	9	found	find	VBN
cord-022353-q2k2krnm	991	10	in	in	IN
cord-022353-q2k2krnm	991	11	mitochondria	mitochondrion	NNS
cord-022353-q2k2krnm	991	12	of	of	IN
cord-022353-q2k2krnm	991	13	many	many	JJ
cord-022353-q2k2krnm	991	14	tissues	tissue	NNS
cord-022353-q2k2krnm	991	15	.	.	.
cord-022353-q2k2krnm	992	1	Serum	serum	NN
cord-022353-q2k2krnm	992	2	CK	CK	NNP
cord-022353-q2k2krnm	992	3	activity	activity	NN
cord-022353-q2k2krnm	992	4	is	be	VBZ
cord-022353-q2k2krnm	992	5	affected	affect	VBN
cord-022353-q2k2krnm	992	6	by	by	IN
cord-022353-q2k2krnm	992	7	age	age	NN
cord-022353-q2k2krnm	992	8	,	,	,
cord-022353-q2k2krnm	992	9	sex	sex	NN
cord-022353-q2k2krnm	992	10	,	,	,
cord-022353-q2k2krnm	992	11	and	and	CC
cord-022353-q2k2krnm	992	12	method	method	NN
cord-022353-q2k2krnm	992	13	of	of	IN
cord-022353-q2k2krnm	992	14	collection	collection	NN
cord-022353-q2k2krnm	992	15	and	and	CC
cord-022353-q2k2krnm	992	16	anesthesia	anesthesia	NN
cord-022353-q2k2krnm	992	17	.	.	.
cord-022353-q2k2krnm	993	1	Patrick	Patrick	NNP
cord-022353-q2k2krnm	993	2	et	et	NNP
cord-022353-q2k2krnm	993	3	al	al	NNP
cord-022353-q2k2krnm	993	4	.	.	.
cord-022353-q2k2krnm	994	1	(	(	-LRB-
cord-022353-q2k2krnm	994	2	1983	1983	CD
cord-022353-q2k2krnm	994	3	)	)	-RRB-
cord-022353-q2k2krnm	994	4	found	find	VBD
cord-022353-q2k2krnm	994	5	that	that	IN
cord-022353-q2k2krnm	994	6	compared	compare	VBN
cord-022353-q2k2krnm	994	7	to	to	IN
cord-022353-q2k2krnm	994	8	jugular	jugular	NNP
cord-022353-q2k2krnm	994	9	vein	vein	NN
cord-022353-q2k2krnm	994	10	collection	collection	NN
cord-022353-q2k2krnm	994	11	,	,	,
cord-022353-q2k2krnm	994	12	cardiac	cardiac	JJ
cord-022353-q2k2krnm	994	13	puncture	puncture	NN
cord-022353-q2k2krnm	994	14	was	be	VBD
cord-022353-q2k2krnm	994	15	associated	associate	VBN
cord-022353-q2k2krnm	994	16	with	with	IN
cord-022353-q2k2krnm	994	17	lower	low	JJR
cord-022353-q2k2krnm	994	18	CK	CK	NNP
cord-022353-q2k2krnm	994	19	activity	activity	NN
cord-022353-q2k2krnm	994	20	.	.	.
cord-022353-q2k2krnm	995	1	Levels	level	NNS
cord-022353-q2k2krnm	995	2	of	of	IN
cord-022353-q2k2krnm	995	3	serum	serum	NN
cord-022353-q2k2krnm	995	4	CK	ck	NN
cord-022353-q2k2krnm	995	5	activity	activity	NN
cord-022353-q2k2krnm	995	6	have	have	VBP
cord-022353-q2k2krnm	995	7	been	be	VBN
cord-022353-q2k2krnm	995	8	reported	report	VBN
cord-022353-q2k2krnm	995	9	for	for	IN
cord-022353-q2k2krnm	995	10	BALC	BALC	NNP
cord-022353-q2k2krnm	995	11	/	/	SYM
cord-022353-q2k2krnm	995	12	cAnN	cann	JJ
cord-022353-q2k2krnm	995	13	mice	mouse	NNS
cord-022353-q2k2krnm	995	14	and	and	CC
cord-022353-q2k2krnm	995	15	C57BL/10	c57bl/10	JJ
cord-022353-q2k2krnm	995	16	mice	mouse	NNS
cord-022353-q2k2krnm	995	17	of	of	IN
cord-022353-q2k2krnm	995	18	varying	vary	VBG
cord-022353-q2k2krnm	995	19	ages	age	NNS
cord-022353-q2k2krnm	995	20	and	and	CC
cord-022353-q2k2krnm	995	21	sex	sex	NN
cord-022353-q2k2krnm	996	1	(	(	-LRB-
cord-022353-q2k2krnm	996	2	Sub	sub	NN
cord-022353-q2k2krnm	996	3	et	et	FW
cord-022353-q2k2krnm	996	4	al	al	NNP
cord-022353-q2k2krnm	996	5	.	.	.
cord-022353-q2k2krnm	996	6	1994	1994	CD
cord-022353-q2k2krnm	996	7	)	)	-RRB-
cord-022353-q2k2krnm	996	8	.	.	.
cord-022353-q2k2krnm	997	1	Serum	serum	NN
cord-022353-q2k2krnm	997	2	CK	CK	NNP
cord-022353-q2k2krnm	997	3	activity	activity	NN
cord-022353-q2k2krnm	997	4	is	be	VBZ
cord-022353-q2k2krnm	997	5	a	a	DT
cord-022353-q2k2krnm	997	6	useful	useful	JJ
cord-022353-q2k2krnm	997	7	and	and	CC
cord-022353-q2k2krnm	997	8	specific	specific	JJ
cord-022353-q2k2krnm	997	9	marker	marker	NN
cord-022353-q2k2krnm	997	10	enzyme	enzyme	NN
cord-022353-q2k2krnm	997	11	of	of	IN
cord-022353-q2k2krnm	997	12	muscle	muscle	NN
cord-022353-q2k2krnm	997	13	injury	injury	NN
cord-022353-q2k2krnm	997	14	,	,	,
cord-022353-q2k2krnm	997	15	because	because	IN
cord-022353-q2k2krnm	997	16	CK	CK	NNP
cord-022353-q2k2krnm	997	17	in	in	IN
cord-022353-q2k2krnm	997	18	central	central	JJ
cord-022353-q2k2krnm	997	19	nervous	nervous	JJ
cord-022353-q2k2krnm	997	20	tissue	tissue	NN
cord-022353-q2k2krnm	997	21	does	do	VBZ
cord-022353-q2k2krnm	997	22	not	not	RB
cord-022353-q2k2krnm	997	23	cross	cross	VB
cord-022353-q2k2krnm	997	24	the	the	DT
cord-022353-q2k2krnm	997	25	blood	blood	NN
cord-022353-q2k2krnm	997	26	-	-	HYPH
cord-022353-q2k2krnm	997	27	brain	brain	NN
cord-022353-q2k2krnm	997	28	barrier	barrier	NN
cord-022353-q2k2krnm	997	29	.	.	.
cord-022353-q2k2krnm	998	1	Sub	Sub	NNP
cord-022353-q2k2krnm	998	2	et	et	FW
cord-022353-q2k2krnm	998	3	aL	aL	NNP
cord-022353-q2k2krnm	998	4	(	(	-LRB-
cord-022353-q2k2krnm	998	5	1994	1994	CD
cord-022353-q2k2krnm	998	6	)	)	-RRB-
cord-022353-q2k2krnm	998	7	compared	compare	VBD
cord-022353-q2k2krnm	998	8	normal	normal	JJ
cord-022353-q2k2krnm	998	9	C57BL/10	c57bl/10	JJ
cord-022353-q2k2krnm	998	10	mice	mouse	NNS
cord-022353-q2k2krnm	998	11	with	with	IN
cord-022353-q2k2krnm	998	12	heterozygous	heterozygous	JJ
cord-022353-q2k2krnm	998	13	male	male	NN
cord-022353-q2k2krnm	998	14	and	and	CC
cord-022353-q2k2krnm	998	15	homozygous	homozygous	JJ
cord-022353-q2k2krnm	998	16	female	female	JJ
cord-022353-q2k2krnm	998	17	mice	mouse	NNS
cord-022353-q2k2krnm	998	18	carrying	carry	VBG
cord-022353-q2k2krnm	998	19	the	the	DT
cord-022353-q2k2krnm	998	20	mdx	mdx	NN
cord-022353-q2k2krnm	998	21	(	(	-LRB-
cord-022353-q2k2krnm	998	22	mutant	mutant	JJ
cord-022353-q2k2krnm	998	23	dystrophin	dystrophin	NN
cord-022353-q2k2krnm	998	24	)	)	-RRB-
cord-022353-q2k2krnm	999	1	allele	allele	NNP
cord-022353-q2k2krnm	999	2	,	,	,
cord-022353-q2k2krnm	999	3	and	and	CC
cord-022353-q2k2krnm	999	4	found	find	VBD
cord-022353-q2k2krnm	999	5	that	that	IN
cord-022353-q2k2krnm	999	6	homozygous	homozygous	JJ
cord-022353-q2k2krnm	999	7	females	female	NNS
cord-022353-q2k2krnm	999	8	have	have	VBP
cord-022353-q2k2krnm	999	9	12-to	12-to	CD
cord-022353-q2k2krnm	999	10	15-fold	15-fold	JJ
cord-022353-q2k2krnm	999	11	increases	increase	NNS
cord-022353-q2k2krnm	999	12	and	and	CC
cord-022353-q2k2krnm	999	13	heterozygous	heterozygous	JJ
cord-022353-q2k2krnm	999	14	males	male	NNS
cord-022353-q2k2krnm	999	15	(	(	-LRB-
cord-022353-q2k2krnm	999	16	mdx	mdx	NNP
cord-022353-q2k2krnm	999	17	/	/	SYM
cord-022353-q2k2krnm	999	18	Y	Y	NNP
cord-022353-q2k2krnm	999	19	)	)	-RRB-
cord-022353-q2k2krnm	999	20	have	have	VBP
cord-022353-q2k2krnm	999	21	30	30	CD
cord-022353-q2k2krnm	999	22	fold	fold	VB
cord-022353-q2k2krnm	999	23	increases	increase	NNS
cord-022353-q2k2krnm	999	24	in	in	IN
cord-022353-q2k2krnm	999	25	plasma	plasma	NN
cord-022353-q2k2krnm	999	26	CK	CK	NNP
cord-022353-q2k2krnm	999	27	compared	compare	VBN
cord-022353-q2k2krnm	999	28	to	to	IN
cord-022353-q2k2krnm	999	29	wild	wild	JJ
cord-022353-q2k2krnm	999	30	-	-	HYPH
cord-022353-q2k2krnm	999	31	type	type	NN
cord-022353-q2k2krnm	999	32	mice	mouse	NNS
cord-022353-q2k2krnm	999	33	.	.	.
cord-022353-q2k2krnm	1000	1	Plasma	plasma	NN
cord-022353-q2k2krnm	1000	2	CK	CK	NNP
cord-022353-q2k2krnm	1000	3	levels	level	NNS
cord-022353-q2k2krnm	1000	4	correlated	correlate	VBN
cord-022353-q2k2krnm	1000	5	with	with	IN
cord-022353-q2k2krnm	1000	6	skeletal	skeletal	JJ
cord-022353-q2k2krnm	1000	7	muscle	muscle	NN
cord-022353-q2k2krnm	1000	8	necrosis	necrosis	NN
cord-022353-q2k2krnm	1000	9	in	in	IN
cord-022353-q2k2krnm	1000	10	these	these	DT
cord-022353-q2k2krnm	1000	11	dystrophic	dystrophic	JJ
cord-022353-q2k2krnm	1000	12	mice	mouse	NNS
cord-022353-q2k2krnm	1000	13	.	.	.
cord-022353-q2k2krnm	1001	1	Mice	mouse	NNS
cord-022353-q2k2krnm	1001	2	have	have	VBP
cord-022353-q2k2krnm	1001	3	been	be	VBN
cord-022353-q2k2krnm	1001	4	engineered	engineer	VBN
cord-022353-q2k2krnm	1001	5	that	that	DT
cord-022353-q2k2krnm	1001	6	lack	lack	NN
cord-022353-q2k2krnm	1001	7	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	1001	8	CK	CK	NNP
cord-022353-q2k2krnm	1001	9	and	and	CC
cord-022353-q2k2krnm	1001	10	CK	CK	NNP
cord-022353-q2k2krnm	1001	11	-	-	HYPH
cord-022353-q2k2krnm	1001	12	Mt	Mt	NNP
cord-022353-q2k2krnm	1001	13	.	.	.
cord-022353-q2k2krnm	1002	1	Mitochondria	mitochondrion	NNS
cord-022353-q2k2krnm	1002	2	from	from	IN
cord-022353-q2k2krnm	1002	3	heart	heart	NN
cord-022353-q2k2krnm	1002	4	or	or	CC
cord-022353-q2k2krnm	1002	5	skeletal	skeletal	JJ
cord-022353-q2k2krnm	1002	6	muscle	muscle	NN
cord-022353-q2k2krnm	1002	7	from	from	IN
cord-022353-q2k2krnm	1002	8	double	double	JJ
cord-022353-q2k2krnm	1002	9	KOs	KOs	NNP
cord-022353-q2k2krnm	1002	10	had	have	VBD
cord-022353-q2k2krnm	1002	11	higher	high	JJR
cord-022353-q2k2krnm	1002	12	ADP	ADP	NNP
cord-022353-q2k2krnm	1002	13	concentrations	concentration	NNS
cord-022353-q2k2krnm	1002	14	compared	compare	VBN
cord-022353-q2k2krnm	1002	15	to	to	IN
cord-022353-q2k2krnm	1002	16	wild	wild	JJ
cord-022353-q2k2krnm	1002	17	-	-	HYPH
cord-022353-q2k2krnm	1002	18	type	type	NN
cord-022353-q2k2krnm	1002	19	animals	animal	NNS
cord-022353-q2k2krnm	1002	20	,	,	,
cord-022353-q2k2krnm	1002	21	suggesting	suggest	VBG
cord-022353-q2k2krnm	1002	22	the	the	DT
cord-022353-q2k2krnm	1002	23	higher	high	JJR
cord-022353-q2k2krnm	1002	24	concentrations	concentration	NNS
cord-022353-q2k2krnm	1002	25	contribute	contribute	VBP
cord-022353-q2k2krnm	1002	26	to	to	IN
cord-022353-q2k2krnm	1002	27	the	the	DT
cord-022353-q2k2krnm	1002	28	control	control	NN
cord-022353-q2k2krnm	1002	29	of	of	IN
cord-022353-q2k2krnm	1002	30	the	the	DT
cord-022353-q2k2krnm	1002	31	reduced	reduced	JJ
cord-022353-q2k2krnm	1002	32	cytosolic	cytosolic	JJ
cord-022353-q2k2krnm	1002	33	ATP	ATP	NNP
cord-022353-q2k2krnm	1002	34	free	free	JJ
cord-022353-q2k2krnm	1002	35	energy	energy	NN
cord-022353-q2k2krnm	1002	36	potentials	potential	NNS
cord-022353-q2k2krnm	1002	37	seen	see	VBN
cord-022353-q2k2krnm	1002	38	in	in	IN
cord-022353-q2k2krnm	1002	39	double	double	JJ
cord-022353-q2k2krnm	1002	40	KOs	KOs	NNP
cord-022353-q2k2krnm	1002	41	.	.	.
cord-022353-q2k2krnm	1003	1	Aldolase	Aldolase	NNP
cord-022353-q2k2krnm	1003	2	is	be	VBZ
cord-022353-q2k2krnm	1003	3	a	a	DT
cord-022353-q2k2krnm	1003	4	cytosolic	cytosolic	JJ
cord-022353-q2k2krnm	1003	5	enzyme	enzyme	NN
cord-022353-q2k2krnm	1003	6	that	that	WDT
cord-022353-q2k2krnm	1003	7	can	can	MD
cord-022353-q2k2krnm	1003	8	alter	alter	VB
cord-022353-q2k2krnm	1003	9	its	-PRON-	PRP$
cord-022353-q2k2krnm	1003	10	distribution	distribution	NN
cord-022353-q2k2krnm	1003	11	between	between	IN
cord-022353-q2k2krnm	1003	12	soluble	soluble	JJ
cord-022353-q2k2krnm	1003	13	and	and	CC
cord-022353-q2k2krnm	1003	14	particulate	particulate	NN
cord-022353-q2k2krnm	1003	15	forms	form	NNS
cord-022353-q2k2krnm	1003	16	,	,	,
cord-022353-q2k2krnm	1003	17	according	accord	VBG
cord-022353-q2k2krnm	1003	18	to	to	IN
cord-022353-q2k2krnm	1003	19	the	the	DT
cord-022353-q2k2krnm	1003	20	metabolic	metabolic	JJ
cord-022353-q2k2krnm	1003	21	status	status	NN
cord-022353-q2k2krnm	1003	22	of	of	IN
cord-022353-q2k2krnm	1003	23	the	the	DT
cord-022353-q2k2krnm	1003	24	tissue	tissue	NN
cord-022353-q2k2krnm	1003	25	.	.	.
cord-022353-q2k2krnm	1004	1	In	in	IN
cord-022353-q2k2krnm	1004	2	adult	adult	NN
cord-022353-q2k2krnm	1004	3	mice	mouse	NNS
cord-022353-q2k2krnm	1004	4	,	,	,
cord-022353-q2k2krnm	1004	5	nine	nine	CD
cord-022353-q2k2krnm	1004	6	aldolase	aldolase	NN
cord-022353-q2k2krnm	1004	7	isoenzymes	isoenzyme	NNS
cord-022353-q2k2krnm	1004	8	are	be	VBP
cord-022353-q2k2krnm	1004	9	known	know	VBN
cord-022353-q2k2krnm	1004	10	to	to	TO
cord-022353-q2k2krnm	1004	11	occur	occur	VB
cord-022353-q2k2krnm	1004	12	in	in	IN
cord-022353-q2k2krnm	1004	13	tissues	tissue	NNS
cord-022353-q2k2krnm	1004	14	with	with	IN
cord-022353-q2k2krnm	1004	15	significant	significant	JJ
cord-022353-q2k2krnm	1004	16	activities	activity	NNS
cord-022353-q2k2krnm	1004	17	in	in	IN
cord-022353-q2k2krnm	1004	18	the	the	DT
cord-022353-q2k2krnm	1004	19	muscle	muscle	NN
cord-022353-q2k2krnm	1004	20	,	,	,
cord-022353-q2k2krnm	1004	21	brain	brain	NN
cord-022353-q2k2krnm	1004	22	,	,	,
cord-022353-q2k2krnm	1004	23	liver	liver	NN
cord-022353-q2k2krnm	1004	24	,	,	,
cord-022353-q2k2krnm	1004	25	kidney	kidney	NN
cord-022353-q2k2krnm	1004	26	,	,	,
cord-022353-q2k2krnm	1004	27	and	and	CC
cord-022353-q2k2krnm	1004	28	spleen	spleen	NNS
cord-022353-q2k2krnm	1004	29	.	.	.
cord-022353-q2k2krnm	1005	1	In	in	IN
cord-022353-q2k2krnm	1005	2	the	the	DT
cord-022353-q2k2krnm	1005	3	mouse	mouse	NN
cord-022353-q2k2krnm	1005	4	liver	liver	NN
cord-022353-q2k2krnm	1005	5	aldolase	aldolase	NN
cord-022353-q2k2krnm	1005	6	,	,	,
cord-022353-q2k2krnm	1005	7	together	together	RB
cord-022353-q2k2krnm	1005	8	with	with	IN
cord-022353-q2k2krnm	1005	9	fructokinase	fructokinase	NN
cord-022353-q2k2krnm	1005	10	and	and	CC
cord-022353-q2k2krnm	1005	11	triokinase	triokinase	NN
cord-022353-q2k2krnm	1005	12	,	,	,
cord-022353-q2k2krnm	1005	13	metabolize	metabolize	VBP
cord-022353-q2k2krnm	1005	14	fructose	fructose	NN
cord-022353-q2k2krnm	1005	15	(	(	-LRB-
cord-022353-q2k2krnm	1005	16	Hagopian	Hagopian	NNP
cord-022353-q2k2krnm	1005	17	et	et	FW
cord-022353-q2k2krnm	1005	18	al	al	NNP
cord-022353-q2k2krnm	1005	19	.	.	NNP
cord-022353-q2k2krnm	1005	20	2005	2005	CD
cord-022353-q2k2krnm	1005	21	)	)	-RRB-
cord-022353-q2k2krnm	1005	22	.	.	.
cord-022353-q2k2krnm	1006	1	Everett	Everett	NNP
cord-022353-q2k2krnm	1006	2	and	and	CC
cord-022353-q2k2krnm	1006	3	Harrison	Harrison	NNP
cord-022353-q2k2krnm	1006	4	(	(	-LRB-
cord-022353-q2k2krnm	1006	5	1983	1983	CD
cord-022353-q2k2krnm	1006	6	)	)	-RRB-
cord-022353-q2k2krnm	1006	7	report	report	VBP
cord-022353-q2k2krnm	1006	8	no	no	DT
cord-022353-q2k2krnm	1006	9	apparent	apparent	JJ
cord-022353-q2k2krnm	1006	10	advantages	advantage	NNS
cord-022353-q2k2krnm	1006	11	in	in	IN
cord-022353-q2k2krnm	1006	12	mice	mouse	NNS
cord-022353-q2k2krnm	1006	13	in	in	IN
cord-022353-q2k2krnm	1006	14	the	the	DT
cord-022353-q2k2krnm	1006	15	measurement	measurement	NN
cord-022353-q2k2krnm	1006	16	of	of	IN
cord-022353-q2k2krnm	1006	17	aldolase	aldolase	NN
cord-022353-q2k2krnm	1006	18	over	over	IN
cord-022353-q2k2krnm	1006	19	other	other	JJ
cord-022353-q2k2krnm	1006	20	enzymes	enzyme	NNS
cord-022353-q2k2krnm	1006	21	known	know	VBN
cord-022353-q2k2krnm	1006	22	to	to	TO
cord-022353-q2k2krnm	1006	23	have	have	VB
cord-022353-q2k2krnm	1006	24	specific	specific	JJ
cord-022353-q2k2krnm	1006	25	liver	liver	NN
cord-022353-q2k2krnm	1006	26	or	or	CC
cord-022353-q2k2krnm	1006	27	muscle	muscle	NN
cord-022353-q2k2krnm	1006	28	activity	activity	NN
cord-022353-q2k2krnm	1006	29	.	.	.
cord-022353-q2k2krnm	1007	1	SDH	SDH	NNP
cord-022353-q2k2krnm	1007	2	is	be	VBZ
cord-022353-q2k2krnm	1007	3	a	a	DT
cord-022353-q2k2krnm	1007	4	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	1007	5	and	and	CC
cord-022353-q2k2krnm	1007	6	mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	1007	7	enzyme	enzyme	NN
cord-022353-q2k2krnm	1007	8	in	in	IN
cord-022353-q2k2krnm	1007	9	which	which	WDT
cord-022353-q2k2krnm	1007	10	serum	serum	NN
cord-022353-q2k2krnm	1007	11	activity	activity	NN
cord-022353-q2k2krnm	1007	12	is	be	VBZ
cord-022353-q2k2krnm	1007	13	increased	increase	VBN
cord-022353-q2k2krnm	1007	14	due	due	IN
cord-022353-q2k2krnm	1007	15	to	to	IN
cord-022353-q2k2krnm	1007	16	leakage	leakage	VB
cord-022353-q2k2krnm	1007	17	across	across	IN
cord-022353-q2k2krnm	1007	18	damaged	damage	VBN
cord-022353-q2k2krnm	1007	19	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	1007	20	and	and	CC
cord-022353-q2k2krnm	1007	21	mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	1007	22	membranes	membrane	NNS
cord-022353-q2k2krnm	1007	23	.	.	.
cord-022353-q2k2krnm	1008	1	SDH	SDH	NNP
cord-022353-q2k2krnm	1008	2	(	(	-LRB-
cord-022353-q2k2krnm	1008	3	also	also	RB
cord-022353-q2k2krnm	1008	4	known	know	VBN
cord-022353-q2k2krnm	1008	5	as	as	IN
cord-022353-q2k2krnm	1008	6	iditol	iditol	NN
cord-022353-q2k2krnm	1008	7	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	1008	8	[	[	-LRB-
cord-022353-q2k2krnm	1008	9	IDH	IDH	NNP
cord-022353-q2k2krnm	1008	10	]	]	-RRB-
cord-022353-q2k2krnm	1008	11	)	)	-RRB-
cord-022353-q2k2krnm	1009	1	reversibly	reversibly	RB
cord-022353-q2k2krnm	1009	2	catalyzes	catalyze	VBZ
cord-022353-q2k2krnm	1009	3	the	the	DT
cord-022353-q2k2krnm	1009	4	conversion	conversion	NN
cord-022353-q2k2krnm	1009	5	of	of	IN
cord-022353-q2k2krnm	1009	6	fructose	fructose	NN
cord-022353-q2k2krnm	1009	7	to	to	IN
cord-022353-q2k2krnm	1009	8	sorbitol	sorbitol	NN
cord-022353-q2k2krnm	1009	9	.	.	.
cord-022353-q2k2krnm	1010	1	Quantification	quantification	NN
cord-022353-q2k2krnm	1010	2	of	of	IN
cord-022353-q2k2krnm	1010	3	serum	serum	NN
cord-022353-q2k2krnm	1010	4	SDH	SDH	NNP
cord-022353-q2k2krnm	1010	5	is	be	VBZ
cord-022353-q2k2krnm	1010	6	based	base	VBN
cord-022353-q2k2krnm	1010	7	on	on	IN
cord-022353-q2k2krnm	1010	8	a	a	DT
cord-022353-q2k2krnm	1010	9	reaction	reaction	NN
cord-022353-q2k2krnm	1010	10	between	between	IN
cord-022353-q2k2krnm	1010	11	SDH	SDH	NNP
cord-022353-q2k2krnm	1010	12	and	and	CC
cord-022353-q2k2krnm	1010	13	a	a	DT
cord-022353-q2k2krnm	1010	14	suitable	suitable	JJ
cord-022353-q2k2krnm	1010	15	substrate	substrate	NN
cord-022353-q2k2krnm	1010	16	(	(	-LRB-
cord-022353-q2k2krnm	1010	17	such	such	JJ
cord-022353-q2k2krnm	1010	18	as	as	IN
cord-022353-q2k2krnm	1010	19	fructose	fructose	NN
cord-022353-q2k2krnm	1010	20	)	)	-RRB-
cord-022353-q2k2krnm	1010	21	.	.	.
cord-022353-q2k2krnm	1011	1	SDH	SDH	NNP
cord-022353-q2k2krnm	1011	2	is	be	VBZ
cord-022353-q2k2krnm	1011	3	located	locate	VBN
cord-022353-q2k2krnm	1011	4	primarily	primarily	RB
cord-022353-q2k2krnm	1011	5	liver	liver	NN
cord-022353-q2k2krnm	1011	6	,	,	,
cord-022353-q2k2krnm	1011	7	kidney	kidney	NN
cord-022353-q2k2krnm	1011	8	,	,	,
cord-022353-q2k2krnm	1011	9	and	and	CC
cord-022353-q2k2krnm	1011	10	seminal	seminal	JJ
cord-022353-q2k2krnm	1011	11	vesicles	vesicle	NNS
cord-022353-q2k2krnm	1011	12	.	.	.
cord-022353-q2k2krnm	1012	1	The	the	DT
cord-022353-q2k2krnm	1012	2	activity	activity	NN
cord-022353-q2k2krnm	1012	3	of	of	IN
cord-022353-q2k2krnm	1012	4	SDH	SDH	NNP
cord-022353-q2k2krnm	1012	5	is	be	VBZ
cord-022353-q2k2krnm	1012	6	usually	usually	RB
cord-022353-q2k2krnm	1012	7	low	low	JJ
cord-022353-q2k2krnm	1012	8	in	in	IN
cord-022353-q2k2krnm	1012	9	the	the	DT
cord-022353-q2k2krnm	1012	10	serum	serum	NN
cord-022353-q2k2krnm	1012	11	and	and	CC
cord-022353-q2k2krnm	1012	12	rises	rise	VBZ
cord-022353-q2k2krnm	1012	13	during	during	IN
cord-022353-q2k2krnm	1012	14	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1012	15	injury	injury	NN
cord-022353-q2k2krnm	1012	16	.	.	.
cord-022353-q2k2krnm	1013	1	However	however	RB
cord-022353-q2k2krnm	1013	2	,	,	,
cord-022353-q2k2krnm	1013	3	the	the	DT
cord-022353-q2k2krnm	1013	4	labile	labile	JJ
cord-022353-q2k2krnm	1013	5	nature	nature	NN
cord-022353-q2k2krnm	1013	6	of	of	IN
cord-022353-q2k2krnm	1013	7	SDH	SDH	NNP
cord-022353-q2k2krnm	1013	8	during	during	IN
cord-022353-q2k2krnm	1013	9	handling	handling	NN
cord-022353-q2k2krnm	1013	10	makes	make	VBZ
cord-022353-q2k2krnm	1013	11	is	be	VBZ
cord-022353-q2k2krnm	1013	12	less	less	RBR
cord-022353-q2k2krnm	1013	13	suitable	suitable	JJ
cord-022353-q2k2krnm	1013	14	overall	overall	RB
cord-022353-q2k2krnm	1013	15	as	as	IN
cord-022353-q2k2krnm	1013	16	a	a	DT
cord-022353-q2k2krnm	1013	17	indicator	indicator	NN
cord-022353-q2k2krnm	1013	18	of	of	IN
cord-022353-q2k2krnm	1013	19	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1013	20	dysfunction	dysfunction	NN
cord-022353-q2k2krnm	1013	21	compared	compare	VBN
cord-022353-q2k2krnm	1013	22	to	to	IN
cord-022353-q2k2krnm	1013	23	over	over	IN
cord-022353-q2k2krnm	1013	24	liver	liver	NN
cord-022353-q2k2krnm	1013	25	-	-	HYPH
cord-022353-q2k2krnm	1013	26	specific	specific	JJ
cord-022353-q2k2krnm	1013	27	enzymes	enzyme	NNS
cord-022353-q2k2krnm	1013	28	(	(	-LRB-
cord-022353-q2k2krnm	1013	29	such	such	JJ
cord-022353-q2k2krnm	1013	30	as	as	IN
cord-022353-q2k2krnm	1013	31	AST	AST	NNP
cord-022353-q2k2krnm	1013	32	)	)	-RRB-
cord-022353-q2k2krnm	1013	33	.	.	.
cord-022353-q2k2krnm	1014	1	Mice	mouse	NNS
cord-022353-q2k2krnm	1014	2	with	with	IN
cord-022353-q2k2krnm	1014	3	the	the	DT
cord-022353-q2k2krnm	1014	4	gene	gene	NN
cord-022353-q2k2krnm	1014	5	for	for	IN
cord-022353-q2k2krnm	1014	6	SDH	SDH	NNP
cord-022353-q2k2krnm	1014	7	knocked	knock	VBD
cord-022353-q2k2krnm	1014	8	out	out	RP
cord-022353-q2k2krnm	1014	9	have	have	VBP
cord-022353-q2k2krnm	1014	10	been	be	VBN
cord-022353-q2k2krnm	1014	11	used	use	VBN
cord-022353-q2k2krnm	1014	12	to	to	TO
cord-022353-q2k2krnm	1014	13	study	study	VB
cord-022353-q2k2krnm	1014	14	the	the	DT
cord-022353-q2k2krnm	1014	15	role	role	NN
cord-022353-q2k2krnm	1014	16	of	of	IN
cord-022353-q2k2krnm	1014	17	sorbitol	sorbitol	NN
cord-022353-q2k2krnm	1014	18	accumulation	accumulation	NN
cord-022353-q2k2krnm	1014	19	in	in	IN
cord-022353-q2k2krnm	1014	20	diabetic	diabetic	JJ
cord-022353-q2k2krnm	1014	21	albuminuria	albuminuria	NNS
cord-022353-q2k2krnm	1014	22	(	(	-LRB-
cord-022353-q2k2krnm	1014	23	Ii	Ii	NNP
cord-022353-q2k2krnm	1014	24	et	et	NNP
cord-022353-q2k2krnm	1014	25	al	al	NNP
cord-022353-q2k2krnm	1014	26	.	.	.
cord-022353-q2k2krnm	1014	27	2004	2004	CD
cord-022353-q2k2krnm	1014	28	)	)	-RRB-
cord-022353-q2k2krnm	1014	29	.	.	.
cord-022353-q2k2krnm	1015	1	Amylase	amylase	NN
cord-022353-q2k2krnm	1015	2	is	be	VBZ
cord-022353-q2k2krnm	1015	3	a	a	DT
cord-022353-q2k2krnm	1015	4	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	1015	5	enzyme	enzyme	NN
cord-022353-q2k2krnm	1015	6	in	in	IN
cord-022353-q2k2krnm	1015	7	which	which	WDT
cord-022353-q2k2krnm	1015	8	serum	serum	NN
cord-022353-q2k2krnm	1015	9	activity	activity	NN
cord-022353-q2k2krnm	1015	10	is	be	VBZ
cord-022353-q2k2krnm	1015	11	increased	increase	VBN
cord-022353-q2k2krnm	1015	12	due	due	IN
cord-022353-q2k2krnm	1015	13	to	to	IN
cord-022353-q2k2krnm	1015	14	leakage	leakage	VB
cord-022353-q2k2krnm	1015	15	across	across	IN
cord-022353-q2k2krnm	1015	16	damaged	damage	VBN
cord-022353-q2k2krnm	1015	17	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	1015	18	membranes	membrane	NNS
cord-022353-q2k2krnm	1015	19	.	.	.
cord-022353-q2k2krnm	1016	1	Amylase	amylase	NN
cord-022353-q2k2krnm	1016	2	hydrolyzes	hydrolyze	VBZ
cord-022353-q2k2krnm	1016	3	complex	complex	JJ
cord-022353-q2k2krnm	1016	4	carbohydrates	carbohydrate	NNS
cord-022353-q2k2krnm	1016	5	to	to	TO
cord-022353-q2k2krnm	1016	6	form	form	VB
cord-022353-q2k2krnm	1016	7	maltose	maltose	NN
cord-022353-q2k2krnm	1016	8	and	and	CC
cord-022353-q2k2krnm	1016	9	glucose	glucose	NN
cord-022353-q2k2krnm	1016	10	in	in	IN
cord-022353-q2k2krnm	1016	11	the	the	DT
cord-022353-q2k2krnm	1016	12	presence	presence	NN
cord-022353-q2k2krnm	1016	13	of	of	IN
cord-022353-q2k2krnm	1016	14	free	free	JJ
cord-022353-q2k2krnm	1016	15	calcium	calcium	NN
cord-022353-q2k2krnm	1016	16	ions	ion	NNS
cord-022353-q2k2krnm	1016	17	.	.	.
cord-022353-q2k2krnm	1017	1	Quantification	quantification	NN
cord-022353-q2k2krnm	1017	2	of	of	IN
cord-022353-q2k2krnm	1017	3	serum	serum	NN
cord-022353-q2k2krnm	1017	4	amylase	amylase	NN
cord-022353-q2k2krnm	1017	5	is	be	VBZ
cord-022353-q2k2krnm	1017	6	based	base	VBN
cord-022353-q2k2krnm	1017	7	on	on	IN
cord-022353-q2k2krnm	1017	8	a	a	DT
cord-022353-q2k2krnm	1017	9	reaction	reaction	NN
cord-022353-q2k2krnm	1017	10	between	between	IN
cord-022353-q2k2krnm	1017	11	amylase	amylase	NN
cord-022353-q2k2krnm	1017	12	and	and	CC
cord-022353-q2k2krnm	1017	13	a	a	DT
cord-022353-q2k2krnm	1017	14	suitable	suitable	JJ
cord-022353-q2k2krnm	1017	15	substrate	substrate	NN
cord-022353-q2k2krnm	1017	16	(	(	-LRB-
cord-022353-q2k2krnm	1017	17	such	such	JJ
cord-022353-q2k2krnm	1017	18	as	as	IN
cord-022353-q2k2krnm	1017	19	starch	starch	NN
cord-022353-q2k2krnm	1017	20	)	)	-RRB-
cord-022353-q2k2krnm	1017	21	.	.	.
cord-022353-q2k2krnm	1018	1	Similar	similar	JJ
cord-022353-q2k2krnm	1018	2	to	to	IN
cord-022353-q2k2krnm	1018	3	humans	human	NNS
cord-022353-q2k2krnm	1018	4	and	and	CC
cord-022353-q2k2krnm	1018	5	pigs	pig	NNS
cord-022353-q2k2krnm	1018	6	(	(	-LRB-
cord-022353-q2k2krnm	1018	7	but	but	CC
cord-022353-q2k2krnm	1018	8	not	not	RB
cord-022353-q2k2krnm	1018	9	dogs	dog	NNS
cord-022353-q2k2krnm	1018	10	,	,	,
cord-022353-q2k2krnm	1018	11	cats	cat	NNS
cord-022353-q2k2krnm	1018	12	,	,	,
cord-022353-q2k2krnm	1018	13	cattle	cattle	NNS
cord-022353-q2k2krnm	1018	14	,	,	,
cord-022353-q2k2krnm	1018	15	and	and	CC
cord-022353-q2k2krnm	1018	16	horses	horse	NNS
cord-022353-q2k2krnm	1018	17	)	)	-RRB-
cord-022353-q2k2krnm	1018	18	,	,	,
cord-022353-q2k2krnm	1018	19	expression	expression	NN
cord-022353-q2k2krnm	1018	20	of	of	IN
cord-022353-q2k2krnm	1018	21	amylase	amylase	NN
cord-022353-q2k2krnm	1018	22	in	in	IN
cord-022353-q2k2krnm	1018	23	mice	mouse	NNS
cord-022353-q2k2krnm	1018	24	is	be	VBZ
cord-022353-q2k2krnm	1018	25	related	relate	VBN
cord-022353-q2k2krnm	1018	26	to	to	IN
cord-022353-q2k2krnm	1018	27	two	two	CD
cord-022353-q2k2krnm	1018	28	distinct	distinct	JJ
cord-022353-q2k2krnm	1018	29	but	but	CC
cord-022353-q2k2krnm	1018	30	closely	closely	RB
cord-022353-q2k2krnm	1018	31	linked	link	VBN
cord-022353-q2k2krnm	1018	32	loci	locus	NNS
cord-022353-q2k2krnm	1018	33	(	(	-LRB-
cord-022353-q2k2krnm	1018	34	Meisler	Meisler	NNP
cord-022353-q2k2krnm	1018	35	et	et	NNP
cord-022353-q2k2krnm	1018	36	al	al	NNP
cord-022353-q2k2krnm	1018	37	.	.	.
cord-022353-q2k2krnm	1018	38	1983	1983	CD
cord-022353-q2k2krnm	1018	39	)	)	-RRB-
cord-022353-q2k2krnm	1018	40	.	.	.
cord-022353-q2k2krnm	1019	1	Salivary	salivary	JJ
cord-022353-q2k2krnm	1019	2	amylase	amylase	NN
cord-022353-q2k2krnm	1019	3	is	be	VBZ
cord-022353-q2k2krnm	1019	4	the	the	DT
cord-022353-q2k2krnm	1019	5	gene	gene	NN
cord-022353-q2k2krnm	1019	6	product	product	NN
cord-022353-q2k2krnm	1019	7	of	of	IN
cord-022353-q2k2krnm	1019	8	Amy-1	Amy-1	NNP
cord-022353-q2k2krnm	1019	9	(	(	-LRB-
cord-022353-q2k2krnm	1019	10	salivary	salivary	NN
cord-022353-q2k2krnm	1019	11	)	)	-RRB-
cord-022353-q2k2krnm	1019	12	,	,	,
cord-022353-q2k2krnm	1019	13	and	and	CC
cord-022353-q2k2krnm	1019	14	appears	appear	VBZ
cord-022353-q2k2krnm	1019	15	to	to	TO
cord-022353-q2k2krnm	1019	16	be	be	VB
cord-022353-q2k2krnm	1019	17	a	a	DT
cord-022353-q2k2krnm	1019	18	single	single	JJ
cord-022353-q2k2krnm	1019	19	enzyme	enzyme	NN
cord-022353-q2k2krnm	1019	20	.	.	.
cord-022353-q2k2krnm	1020	1	Pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	1020	2	amylase	amylase	NN
cord-022353-q2k2krnm	1020	3	is	be	VBZ
cord-022353-q2k2krnm	1020	4	the	the	DT
cord-022353-q2k2krnm	1020	5	gene	gene	NN
cord-022353-q2k2krnm	1020	6	product	product	NN
cord-022353-q2k2krnm	1020	7	of	of	IN
cord-022353-q2k2krnm	1020	8	Amy-2	Amy-2	NNP
cord-022353-q2k2krnm	1020	9	,	,	,
cord-022353-q2k2krnm	1020	10	and	and	CC
cord-022353-q2k2krnm	1020	11	based	base	VBN
cord-022353-q2k2krnm	1020	12	on	on	IN
cord-022353-q2k2krnm	1020	13	electrophoretic	electrophoretic	JJ
cord-022353-q2k2krnm	1020	14	studies	study	NNS
cord-022353-q2k2krnm	1020	15	in	in	IN
cord-022353-q2k2krnm	1020	16	inbred	inbred	JJ
cord-022353-q2k2krnm	1020	17	mice	mouse	NNS
cord-022353-q2k2krnm	1020	18	,	,	,
cord-022353-q2k2krnm	1020	19	there	there	EX
cord-022353-q2k2krnm	1020	20	appear	appear	VBP
cord-022353-q2k2krnm	1020	21	to	to	IN
cord-022353-q2k2krnm	1020	22	four	four	CD
cord-022353-q2k2krnm	1020	23	isoenzyme	isoenzyme	NNS
cord-022353-q2k2krnm	1020	24	classes	class	NNS
cord-022353-q2k2krnm	1020	25	:	:	:
cord-022353-q2k2krnm	1020	26	A1	A1	NNP
cord-022353-q2k2krnm	1020	27	,	,	,
cord-022353-q2k2krnm	1020	28	A2	A2	NNP
cord-022353-q2k2krnm	1020	29	,	,	,
cord-022353-q2k2krnm	1020	30	B	B	NNP
cord-022353-q2k2krnm	1020	31	1	1	CD
cord-022353-q2k2krnm	1020	32	,	,	,
cord-022353-q2k2krnm	1020	33	and	and	CC
cord-022353-q2k2krnm	1020	34	B2	b2	NN
cord-022353-q2k2krnm	1020	35	.	.	.
cord-022353-q2k2krnm	1021	1	Similar	similar	JJ
cord-022353-q2k2krnm	1021	2	to	to	IN
cord-022353-q2k2krnm	1021	3	other	other	JJ
cord-022353-q2k2krnm	1021	4	domestic	domestic	JJ
cord-022353-q2k2krnm	1021	5	animal	animal	NN
cord-022353-q2k2krnm	1021	6	species	specie	NNS
cord-022353-q2k2krnm	1021	7	,	,	,
cord-022353-q2k2krnm	1021	8	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	1021	9	amylase	amylase	NN
cord-022353-q2k2krnm	1021	10	is	be	VBZ
cord-022353-q2k2krnm	1021	11	filtered	filter	VBN
cord-022353-q2k2krnm	1021	12	through	through	IN
cord-022353-q2k2krnm	1021	13	the	the	DT
cord-022353-q2k2krnm	1021	14	glomerulus	glomerulus	NN
cord-022353-q2k2krnm	1021	15	,	,	,
cord-022353-q2k2krnm	1021	16	but	but	CC
cord-022353-q2k2krnm	1021	17	unlike	unlike	IN
cord-022353-q2k2krnm	1021	18	other	other	JJ
cord-022353-q2k2krnm	1021	19	domestic	domestic	JJ
cord-022353-q2k2krnm	1021	20	species	specie	NNS
cord-022353-q2k2krnm	1021	21	,	,	,
cord-022353-q2k2krnm	1021	22	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	1021	23	amylase	amylase	NN
cord-022353-q2k2krnm	1021	24	is	be	VBZ
cord-022353-q2k2krnm	1021	25	not	not	RB
cord-022353-q2k2krnm	1021	26	resorbed	resorb	VBN
cord-022353-q2k2krnm	1021	27	by	by	IN
cord-022353-q2k2krnm	1021	28	renal	renal	JJ
cord-022353-q2k2krnm	1021	29	tubular	tubular	JJ
cord-022353-q2k2krnm	1021	30	epithelial	epithelial	JJ
cord-022353-q2k2krnm	1021	31	cells	cell	NNS
cord-022353-q2k2krnm	1021	32	and	and	CC
cord-022353-q2k2krnm	1021	33	is	be	VBZ
cord-022353-q2k2krnm	1021	34	excreted	excrete	VBN
cord-022353-q2k2krnm	1021	35	rapidly	rapidly	RB
cord-022353-q2k2krnm	1021	36	in	in	IN
cord-022353-q2k2krnm	1021	37	the	the	DT
cord-022353-q2k2krnm	1021	38	urine	urine	NN
cord-022353-q2k2krnm	1021	39	.	.	.
cord-022353-q2k2krnm	1022	1	Therefore	therefore	RB
cord-022353-q2k2krnm	1022	2	normal	normal	JJ
cord-022353-q2k2krnm	1022	3	serum	serum	NN
cord-022353-q2k2krnm	1022	4	amylase	amylase	NN
cord-022353-q2k2krnm	1022	5	activity	activity	NN
cord-022353-q2k2krnm	1022	6	in	in	IN
cord-022353-q2k2krnm	1022	7	mice	mouse	NNS
cord-022353-q2k2krnm	1022	8	consists	consist	VBZ
cord-022353-q2k2krnm	1022	9	mainly	mainly	RB
cord-022353-q2k2krnm	1022	10	of	of	IN
cord-022353-q2k2krnm	1022	11	salivary	salivary	JJ
cord-022353-q2k2krnm	1022	12	amylase	amylase	NN
cord-022353-q2k2krnm	1022	13	(	(	-LRB-
cord-022353-q2k2krnm	1022	14	Mackenzie	Mackenzie	NNP
cord-022353-q2k2krnm	1022	15	and	and	CC
cord-022353-q2k2krnm	1022	16	Messer	Messer	NNP
cord-022353-q2k2krnm	1022	17	1976	1976	CD
cord-022353-q2k2krnm	1022	18	)	)	-RRB-
cord-022353-q2k2krnm	1022	19	.	.	.
cord-022353-q2k2krnm	1023	1	Despite	despite	IN
cord-022353-q2k2krnm	1023	2	this	this	DT
cord-022353-q2k2krnm	1023	3	,	,	,
cord-022353-q2k2krnm	1023	4	elevations	elevation	NNS
cord-022353-q2k2krnm	1023	5	in	in	IN
cord-022353-q2k2krnm	1023	6	serum	serum	NN
cord-022353-q2k2krnm	1023	7	amylase	amylase	NN
cord-022353-q2k2krnm	1023	8	activity	activity	NN
cord-022353-q2k2krnm	1023	9	is	be	VBZ
cord-022353-q2k2krnm	1023	10	usually	usually	RB
cord-022353-q2k2krnm	1023	11	considered	consider	VBN
cord-022353-q2k2krnm	1023	12	a	a	DT
cord-022353-q2k2krnm	1023	13	reliable	reliable	JJ
cord-022353-q2k2krnm	1023	14	marker	marker	NN
cord-022353-q2k2krnm	1023	15	for	for	IN
cord-022353-q2k2krnm	1023	16	pancreatitis	pancreatitis	NN
cord-022353-q2k2krnm	1023	17	in	in	IN
cord-022353-q2k2krnm	1023	18	mice	mouse	NNS
cord-022353-q2k2krnm	1024	1	(	(	-LRB-
cord-022353-q2k2krnm	1024	2	Nathan	Nathan	NNP
cord-022353-q2k2krnm	1024	3	et	et	NNP
cord-022353-q2k2krnm	1024	4	al	al	NNP
cord-022353-q2k2krnm	1024	5	.	.	NNP
cord-022353-q2k2krnm	1024	6	2005	2005	CD
cord-022353-q2k2krnm	1024	7	)	)	-RRB-
cord-022353-q2k2krnm	1024	8	.	.	.
cord-022353-q2k2krnm	1025	1	Ross	Ross	NNP
cord-022353-q2k2krnm	1025	2	et	et	NNP
cord-022353-q2k2krnm	1025	3	al	al	NNP
cord-022353-q2k2krnm	1025	4	.	.	.
cord-022353-q2k2krnm	1026	1	(	(	-LRB-
cord-022353-q2k2krnm	1026	2	1974	1974	CD
cord-022353-q2k2krnm	1026	3	)	)	-RRB-
cord-022353-q2k2krnm	1026	4	reported	report	VBD
cord-022353-q2k2krnm	1026	5	two	two	CD
cord-022353-q2k2krnm	1026	6	-	-	HYPH
cord-022353-q2k2krnm	1026	7	to	to	IN
cord-022353-q2k2krnm	1026	8	three	three	CD
cord-022353-q2k2krnm	1026	9	-	-	HYPH
cord-022353-q2k2krnm	1026	10	fold	fold	NN
cord-022353-q2k2krnm	1026	11	increases	increase	NNS
cord-022353-q2k2krnm	1026	12	in	in	IN
cord-022353-q2k2krnm	1026	13	serum	serum	NN
cord-022353-q2k2krnm	1026	14	amylase	amylase	NN
cord-022353-q2k2krnm	1026	15	activity	activity	NN
cord-022353-q2k2krnm	1026	16	in	in	IN
cord-022353-q2k2krnm	1026	17	mice	mouse	NNS
cord-022353-q2k2krnm	1026	18	infected	infect	VBN
cord-022353-q2k2krnm	1026	19	with	with	IN
cord-022353-q2k2krnm	1026	20	Coxsackievirus	Coxsackievirus	NNP
cord-022353-q2k2krnm	1026	21	of	of	IN
cord-022353-q2k2krnm	1026	22	salivary	salivary	NN
cord-022353-q2k2krnm	1026	23	and	and	CC
cord-022353-q2k2krnm	1026	24	pancreatic	pancreatic	NN
cord-022353-q2k2krnm	1026	25	trophism	trophism	NN
cord-022353-q2k2krnm	1026	26	.	.	.
cord-022353-q2k2krnm	1027	1	Alterations	alteration	NNS
cord-022353-q2k2krnm	1027	2	in	in	IN
cord-022353-q2k2krnm	1027	3	the	the	DT
cord-022353-q2k2krnm	1027	4	activity	activity	NN
cord-022353-q2k2krnm	1027	5	of	of	IN
cord-022353-q2k2krnm	1027	6	specific	specific	JJ
cord-022353-q2k2krnm	1027	7	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	1027	8	isoenzymes	isoenzyme	NNS
cord-022353-q2k2krnm	1027	9	have	have	VBP
cord-022353-q2k2krnm	1027	10	been	be	VBN
cord-022353-q2k2krnm	1027	11	shown	show	VBN
cord-022353-q2k2krnm	1027	12	in	in	IN
cord-022353-q2k2krnm	1027	13	streptozotocin	streptozotocin	NNS
cord-022353-q2k2krnm	1027	14	-	-	HYPH
cord-022353-q2k2krnm	1027	15	induced	induce	VBN
cord-022353-q2k2krnm	1027	16	diabetes	diabetes	NN
cord-022353-q2k2krnm	1027	17	in	in	IN
cord-022353-q2k2krnm	1027	18	mice	mouse	NNS
cord-022353-q2k2krnm	1027	19	(	(	-LRB-
cord-022353-q2k2krnm	1027	20	Quimby	Quimby	NNP
cord-022353-q2k2krnm	1027	21	1999b	1999b	CD
cord-022353-q2k2krnm	1027	22	)	)	-RRB-
cord-022353-q2k2krnm	1027	23	.	.	.
cord-022353-q2k2krnm	1028	1	There	there	EX
cord-022353-q2k2krnm	1028	2	are	be	VBP
cord-022353-q2k2krnm	1028	3	two	two	CD
cord-022353-q2k2krnm	1028	4	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	1028	5	lipase	lipase	NN
cord-022353-q2k2krnm	1028	6	isoenzymes	isoenzyme	NNS
cord-022353-q2k2krnm	1028	7	in	in	IN
cord-022353-q2k2krnm	1028	8	mice	mouse	NNS
cord-022353-q2k2krnm	1028	9	.	.	.
cord-022353-q2k2krnm	1029	1	Serum	serum	NN
cord-022353-q2k2krnm	1029	2	lipase	lipase	NN
cord-022353-q2k2krnm	1029	3	activity	activity	NN
cord-022353-q2k2krnm	1029	4	has	have	VBZ
cord-022353-q2k2krnm	1029	5	been	be	VBN
cord-022353-q2k2krnm	1029	6	used	use	VBN
cord-022353-q2k2krnm	1029	7	to	to	TO
cord-022353-q2k2krnm	1029	8	monitor	monitor	VB
cord-022353-q2k2krnm	1029	9	cerulean	cerulean	NN
cord-022353-q2k2krnm	1029	10	-	-	HYPH
cord-022353-q2k2krnm	1029	11	induced	induce	VBN
cord-022353-q2k2krnm	1029	12	acute	acute	JJ
cord-022353-q2k2krnm	1029	13	pancreatitis	pancreatitis	NN
cord-022353-q2k2krnm	1029	14	in	in	IN
cord-022353-q2k2krnm	1029	15	mice	mouse	NNS
cord-022353-q2k2krnm	1030	1	(	(	-LRB-
cord-022353-q2k2krnm	1030	2	Cuzzocrea	Cuzzocrea	NNP
cord-022353-q2k2krnm	1030	3	et	et	NNP
cord-022353-q2k2krnm	1030	4	al	al	NNP
cord-022353-q2k2krnm	1030	5	.	.	.
cord-022353-q2k2krnm	1030	6	2004	2004	CD
cord-022353-q2k2krnm	1030	7	)	)	-RRB-
cord-022353-q2k2krnm	1030	8	.	.	.
cord-022353-q2k2krnm	1031	1	Recently	recently	RB
cord-022353-q2k2krnm	1031	2	a	a	DT
cord-022353-q2k2krnm	1031	3	new	new	JJ
cord-022353-q2k2krnm	1031	4	colipase	colipase	NN
cord-022353-q2k2krnm	1031	5	-	-	HYPH
cord-022353-q2k2krnm	1031	6	dependent	dependent	JJ
cord-022353-q2k2krnm	1031	7	lipase	lipase	NN
cord-022353-q2k2krnm	1031	8	has	have	VBZ
cord-022353-q2k2krnm	1031	9	been	be	VBN
cord-022353-q2k2krnm	1031	10	described	describe	VBN
cord-022353-q2k2krnm	1031	11	in	in	IN
cord-022353-q2k2krnm	1031	12	suckling	suckle	VBG
cord-022353-q2k2krnm	1031	13	mice	mouse	NNS
cord-022353-q2k2krnm	1031	14	(	(	-LRB-
cord-022353-q2k2krnm	1031	15	D'Agostino	D'Agostino	NNP
cord-022353-q2k2krnm	1031	16	and	and	CC
cord-022353-q2k2krnm	1031	17	Lowe	Lowe	NNP
cord-022353-q2k2krnm	1031	18	2004	2004	CD
cord-022353-q2k2krnm	1031	19	)	)	-RRB-
cord-022353-q2k2krnm	1031	20	.	.	.
cord-022353-q2k2krnm	1032	1	The	the	DT
cord-022353-q2k2krnm	1032	2	enzyme	enzyme	NN
cord-022353-q2k2krnm	1032	3	5'-nucleotidase	5'-nucleotidase	CD
cord-022353-q2k2krnm	1032	4	was	be	VBD
cord-022353-q2k2krnm	1032	5	measured	measure	VBN
cord-022353-q2k2krnm	1032	6	in	in	IN
cord-022353-q2k2krnm	1032	7	the	the	DT
cord-022353-q2k2krnm	1032	8	serum	serum	NN
cord-022353-q2k2krnm	1032	9	of	of	IN
cord-022353-q2k2krnm	1032	10	normal	normal	JJ
cord-022353-q2k2krnm	1032	11	mice	mouse	NNS
cord-022353-q2k2krnm	1032	12	using	use	VBG
cord-022353-q2k2krnm	1032	13	a	a	DT
cord-022353-q2k2krnm	1032	14	simple	simple	JJ
cord-022353-q2k2krnm	1032	15	one	one	CD
cord-022353-q2k2krnm	1032	16	-	-	HYPH
cord-022353-q2k2krnm	1032	17	step	step	NN
cord-022353-q2k2krnm	1032	18	kinetic	kinetic	JJ
cord-022353-q2k2krnm	1032	19	method	method	NN
cord-022353-q2k2krnm	1032	20	(	(	-LRB-
cord-022353-q2k2krnm	1032	21	Dooley	Dooley	NNP
cord-022353-q2k2krnm	1032	22	and	and	CC
cord-022353-q2k2krnm	1032	23	Racich	Racich	NNP
cord-022353-q2k2krnm	1032	24	1980	1980	CD
cord-022353-q2k2krnm	1032	25	)	)	-RRB-
cord-022353-q2k2krnm	1032	26	.	.	.
cord-022353-q2k2krnm	1033	1	A	a	DT
cord-022353-q2k2krnm	1033	2	reference	reference	NN
cord-022353-q2k2krnm	1033	3	range	range	NN
cord-022353-q2k2krnm	1033	4	of	of	IN
cord-022353-q2k2krnm	1033	5	10.9	10.9	CD
cord-022353-q2k2krnm	1033	6	+	+	SYM
cord-022353-q2k2krnm	1033	7	4.5	4.5	CD
cord-022353-q2k2krnm	1034	1	(	(	-LRB-
cord-022353-q2k2krnm	1034	2	SD	SD	NNP
cord-022353-q2k2krnm	1034	3	)	)	-RRB-
cord-022353-q2k2krnm	1034	4	U/1	u/1	NN
cord-022353-q2k2krnm	1034	5	has	have	VBZ
cord-022353-q2k2krnm	1034	6	been	be	VBN
cord-022353-q2k2krnm	1034	7	recorded	record	VBN
cord-022353-q2k2krnm	1034	8	in	in	IN
cord-022353-q2k2krnm	1034	9	100	100	CD
cord-022353-q2k2krnm	1034	10	mice	mouse	NNS
cord-022353-q2k2krnm	1034	11	,	,	,
cord-022353-q2k2krnm	1034	12	and	and	CC
cord-022353-q2k2krnm	1034	13	it	-PRON-	PRP
cord-022353-q2k2krnm	1034	14	is	be	VBZ
cord-022353-q2k2krnm	1034	15	thought	think	VBN
cord-022353-q2k2krnm	1034	16	but	but	CC
cord-022353-q2k2krnm	1034	17	not	not	RB
cord-022353-q2k2krnm	1034	18	proven	prove	VBN
cord-022353-q2k2krnm	1034	19	to	to	TO
cord-022353-q2k2krnm	1034	20	be	be	VB
cord-022353-q2k2krnm	1034	21	a	a	DT
cord-022353-q2k2krnm	1034	22	good	good	JJ
cord-022353-q2k2krnm	1034	23	indicator	indicator	NN
cord-022353-q2k2krnm	1034	24	of	of	IN
cord-022353-q2k2krnm	1034	25	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1034	26	injury	injury	NN
cord-022353-q2k2krnm	1034	27	(	(	-LRB-
cord-022353-q2k2krnm	1034	28	Clampitt	Clampitt	NNP
cord-022353-q2k2krnm	1034	29	and	and	CC
cord-022353-q2k2krnm	1034	30	Hart	Hart	NNP
cord-022353-q2k2krnm	1034	31	1978	1978	CD
cord-022353-q2k2krnm	1034	32	)	)	-RRB-
cord-022353-q2k2krnm	1034	33	.	.	.
cord-022353-q2k2krnm	1035	1	Glutamate	glutamate	NN
cord-022353-q2k2krnm	1035	2	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	1035	3	(	(	-LRB-
cord-022353-q2k2krnm	1035	4	GDH	GDH	NNP
cord-022353-q2k2krnm	1035	5	)	)	-RRB-
cord-022353-q2k2krnm	1035	6	has	have	VBZ
cord-022353-q2k2krnm	1035	7	been	be	VBN
cord-022353-q2k2krnm	1035	8	measured	measure	VBN
cord-022353-q2k2krnm	1035	9	in	in	IN
cord-022353-q2k2krnm	1035	10	the	the	DT
cord-022353-q2k2krnm	1035	11	tissues	tissue	NNS
cord-022353-q2k2krnm	1035	12	and	and	CC
cord-022353-q2k2krnm	1035	13	serum	serum	NN
cord-022353-q2k2krnm	1035	14	of	of	IN
cord-022353-q2k2krnm	1035	15	mice	mouse	NNS
cord-022353-q2k2krnm	1035	16	.	.	.
cord-022353-q2k2krnm	1036	1	GDH	GDH	NNP
cord-022353-q2k2krnm	1036	2	is	be	VBZ
cord-022353-q2k2krnm	1036	3	known	know	VBN
cord-022353-q2k2krnm	1036	4	to	to	TO
cord-022353-q2k2krnm	1036	5	play	play	VB
cord-022353-q2k2krnm	1036	6	a	a	DT
cord-022353-q2k2krnm	1036	7	key	key	JJ
cord-022353-q2k2krnm	1036	8	role	role	NN
cord-022353-q2k2krnm	1036	9	in	in	IN
cord-022353-q2k2krnm	1036	10	insulin	insulin	NN
cord-022353-q2k2krnm	1036	11	secretion	secretion	NN
cord-022353-q2k2krnm	1037	1	(	(	-LRB-
cord-022353-q2k2krnm	1037	2	Carobbio	Carobbio	NNP
cord-022353-q2k2krnm	1037	3	et	et	NNP
cord-022353-q2k2krnm	1037	4	aL	aL	NNP
cord-022353-q2k2krnm	1037	5	2004	2004	CD
cord-022353-q2k2krnm	1037	6	)	)	-RRB-
cord-022353-q2k2krnm	1037	7	.	.	.
cord-022353-q2k2krnm	1038	1	The	the	DT
cord-022353-q2k2krnm	1038	2	activity	activity	NN
cord-022353-q2k2krnm	1038	3	of	of	IN
cord-022353-q2k2krnm	1038	4	GDH	GDH	NNP
cord-022353-q2k2krnm	1038	5	is	be	VBZ
cord-022353-q2k2krnm	1038	6	fivefold	fivefold	RB
cord-022353-q2k2krnm	1038	7	greater	great	JJR
cord-022353-q2k2krnm	1038	8	in	in	IN
cord-022353-q2k2krnm	1038	9	the	the	DT
cord-022353-q2k2krnm	1038	10	liver	liver	NN
cord-022353-q2k2krnm	1038	11	than	than	IN
cord-022353-q2k2krnm	1038	12	in	in	IN
cord-022353-q2k2krnm	1038	13	the	the	DT
cord-022353-q2k2krnm	1038	14	kidney	kidney	NN
cord-022353-q2k2krnm	1038	15	and	and	CC
cord-022353-q2k2krnm	1038	16	brain	brain	NN
cord-022353-q2k2krnm	1038	17	,	,	,
cord-022353-q2k2krnm	1038	18	and	and	CC
cord-022353-q2k2krnm	1038	19	the	the	DT
cord-022353-q2k2krnm	1038	20	authors	author	NNS
cord-022353-q2k2krnm	1038	21	speculated	speculate	VBD
cord-022353-q2k2krnm	1038	22	that	that	IN
cord-022353-q2k2krnm	1038	23	its	-PRON-	PRP$
cord-022353-q2k2krnm	1038	24	measurement	measurement	NN
cord-022353-q2k2krnm	1038	25	in	in	IN
cord-022353-q2k2krnm	1038	26	serum	serum	NN
cord-022353-q2k2krnm	1038	27	would	would	MD
cord-022353-q2k2krnm	1038	28	be	be	VB
cord-022353-q2k2krnm	1038	29	a	a	DT
cord-022353-q2k2krnm	1038	30	sensitive	sensitive	JJ
cord-022353-q2k2krnm	1038	31	indicator	indicator	NN
cord-022353-q2k2krnm	1038	32	of	of	IN
cord-022353-q2k2krnm	1038	33	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1038	34	cell	cell	NN
cord-022353-q2k2krnm	1038	35	injury	injury	NN
cord-022353-q2k2krnm	1038	36	.	.	.
cord-022353-q2k2krnm	1039	1	Serum	serum	NN
cord-022353-q2k2krnm	1039	2	GDH	GDH	NNP
cord-022353-q2k2krnm	1039	3	activity	activity	NN
cord-022353-q2k2krnm	1039	4	is	be	VBZ
cord-022353-q2k2krnm	1039	5	also	also	RB
cord-022353-q2k2krnm	1039	6	elevated	elevate	VBN
cord-022353-q2k2krnm	1039	7	in	in	IN
cord-022353-q2k2krnm	1039	8	mice	mouse	NNS
cord-022353-q2k2krnm	1039	9	on	on	IN
cord-022353-q2k2krnm	1039	10	caloric	caloric	JJ
cord-022353-q2k2krnm	1039	11	restriction	restriction	NN
cord-022353-q2k2krnm	1040	1	(	(	-LRB-
cord-022353-q2k2krnm	1040	2	Hagopian	Hagopian	NNP
cord-022353-q2k2krnm	1040	3	et	et	FW
cord-022353-q2k2krnm	1040	4	al	al	NNP
cord-022353-q2k2krnm	1040	5	.	.	NNP
cord-022353-q2k2krnm	1040	6	2003	2003	CD
cord-022353-q2k2krnm	1040	7	)	)	-RRB-
cord-022353-q2k2krnm	1040	8	.	.	.
cord-022353-q2k2krnm	1041	1	Corticosterone	Corticosterone	NNP
cord-022353-q2k2krnm	1041	2	is	be	VBZ
cord-022353-q2k2krnm	1041	3	the	the	DT
cord-022353-q2k2krnm	1041	4	major	major	JJ
cord-022353-q2k2krnm	1041	5	glucocorticoid	glucocorticoid	NN
cord-022353-q2k2krnm	1041	6	secreted	secrete	VBN
cord-022353-q2k2krnm	1041	7	by	by	IN
cord-022353-q2k2krnm	1041	8	the	the	DT
cord-022353-q2k2krnm	1041	9	adrenal	adrenal	JJ
cord-022353-q2k2krnm	1041	10	cortex	cortex	NN
cord-022353-q2k2krnm	1041	11	of	of	IN
cord-022353-q2k2krnm	1041	12	mice	mouse	NNS
cord-022353-q2k2krnm	1041	13	.	.	.
cord-022353-q2k2krnm	1042	1	It	-PRON-	PRP
cord-022353-q2k2krnm	1042	2	functions	function	VBZ
cord-022353-q2k2krnm	1042	3	as	as	IN
cord-022353-q2k2krnm	1042	4	a	a	DT
cord-022353-q2k2krnm	1042	5	regulator	regulator	NN
cord-022353-q2k2krnm	1042	6	of	of	IN
cord-022353-q2k2krnm	1042	7	carbohydrate	carbohydrate	NN
cord-022353-q2k2krnm	1042	8	,	,	,
cord-022353-q2k2krnm	1042	9	protein	protein	NN
cord-022353-q2k2krnm	1042	10	,	,	,
cord-022353-q2k2krnm	1042	11	and	and	CC
cord-022353-q2k2krnm	1042	12	fat	fat	JJ
cord-022353-q2k2krnm	1042	13	metabolism	metabolism	NN
cord-022353-q2k2krnm	1042	14	and	and	CC
cord-022353-q2k2krnm	1042	15	modifies	modify	VBZ
cord-022353-q2k2krnm	1042	16	the	the	DT
cord-022353-q2k2krnm	1042	17	host	host	NN
cord-022353-q2k2krnm	1042	18	response	response	NN
cord-022353-q2k2krnm	1042	19	to	to	IN
cord-022353-q2k2krnm	1042	20	stress	stress	NN
cord-022353-q2k2krnm	1042	21	.	.	.
cord-022353-q2k2krnm	1043	1	The	the	DT
cord-022353-q2k2krnm	1043	2	male	male	JJ
cord-022353-q2k2krnm	1043	3	mouse	mouse	NN
cord-022353-q2k2krnm	1043	4	has	have	VBZ
cord-022353-q2k2krnm	1043	5	a	a	DT
cord-022353-q2k2krnm	1043	6	well	well	RB
cord-022353-q2k2krnm	1043	7	-	-	HYPH
cord-022353-q2k2krnm	1043	8	defined	define	VBN
cord-022353-q2k2krnm	1043	9	diurnal	diurnal	JJ
cord-022353-q2k2krnm	1043	10	concentration	concentration	NN
cord-022353-q2k2krnm	1043	11	pattern	pattern	NN
cord-022353-q2k2krnm	1043	12	,	,	,
cord-022353-q2k2krnm	1043	13	with	with	IN
cord-022353-q2k2krnm	1043	14	a	a	DT
cord-022353-q2k2krnm	1043	15	maximum	maximum	JJ
cord-022353-q2k2krnm	1043	16	concentration	concentration	NN
cord-022353-q2k2krnm	1043	17	of	of	IN
cord-022353-q2k2krnm	1043	18	9	9	CD
cord-022353-q2k2krnm	1043	19	ktg	ktg	NNP
cord-022353-q2k2krnm	1043	20	/	/	SYM
cord-022353-q2k2krnm	1043	21	dl	dl	NN
cord-022353-q2k2krnm	1043	22	at	at	IN
cord-022353-q2k2krnm	1043	23	the	the	DT
cord-022353-q2k2krnm	1043	24	start	start	NN
cord-022353-q2k2krnm	1043	25	of	of	IN
cord-022353-q2k2krnm	1043	26	the	the	DT
cord-022353-q2k2krnm	1043	27	dark	dark	JJ
cord-022353-q2k2krnm	1043	28	cycle	cycle	NN
cord-022353-q2k2krnm	1043	29	and	and	CC
cord-022353-q2k2krnm	1043	30	a	a	DT
cord-022353-q2k2krnm	1043	31	minimum	minimum	JJ
cord-022353-q2k2krnm	1043	32	concentration	concentration	NN
cord-022353-q2k2krnm	1043	33	of	of	IN
cord-022353-q2k2krnm	1043	34	5	5	CD
cord-022353-q2k2krnm	1043	35	btg	btg	NNP
cord-022353-q2k2krnm	1043	36	/	/	SYM
cord-022353-q2k2krnm	1043	37	dl	dl	NNP
cord-022353-q2k2krnm	1043	38	shortly	shortly	RB
cord-022353-q2k2krnm	1043	39	before	before	IN
cord-022353-q2k2krnm	1043	40	the	the	DT
cord-022353-q2k2krnm	1043	41	end	end	NN
cord-022353-q2k2krnm	1043	42	of	of	IN
cord-022353-q2k2krnm	1043	43	the	the	DT
cord-022353-q2k2krnm	1043	44	dark	dark	JJ
cord-022353-q2k2krnm	1043	45	cycle	cycle	NN
cord-022353-q2k2krnm	1043	46	(	(	-LRB-
cord-022353-q2k2krnm	1043	47	Ottenweller	Ottenweller	NNP
cord-022353-q2k2krnm	1043	48	et	et	NNP
cord-022353-q2k2krnm	1043	49	al	al	NNP
cord-022353-q2k2krnm	1043	50	.	.	.
cord-022353-q2k2krnm	1043	51	1979	1979	CD
cord-022353-q2k2krnm	1043	52	)	)	-RRB-
cord-022353-q2k2krnm	1043	53	.	.	.
cord-022353-q2k2krnm	1044	1	In	in	IN
cord-022353-q2k2krnm	1044	2	contrast	contrast	NN
cord-022353-q2k2krnm	1044	3	,	,	,
cord-022353-q2k2krnm	1044	4	female	female	JJ
cord-022353-q2k2krnm	1044	5	mice	mouse	NNS
cord-022353-q2k2krnm	1044	6	have	have	VBP
cord-022353-q2k2krnm	1044	7	a	a	DT
cord-022353-q2k2krnm	1044	8	minimum	minimum	JJ
cord-022353-q2k2krnm	1044	9	concentration	concentration	NN
cord-022353-q2k2krnm	1044	10	of	of	IN
cord-022353-q2k2krnm	1044	11	13.5	13.5	CD
cord-022353-q2k2krnm	1044	12	ktg	ktg	NNP
cord-022353-q2k2krnm	1044	13	/	/	SYM
cord-022353-q2k2krnm	1044	14	dl	dl	NN
cord-022353-q2k2krnm	1044	15	at	at	IN
cord-022353-q2k2krnm	1044	16	the	the	DT
cord-022353-q2k2krnm	1044	17	beginning	beginning	NN
cord-022353-q2k2krnm	1044	18	of	of	IN
cord-022353-q2k2krnm	1044	19	the	the	DT
cord-022353-q2k2krnm	1044	20	dark	dark	JJ
cord-022353-q2k2krnm	1044	21	cycle	cycle	NN
cord-022353-q2k2krnm	1044	22	and	and	CC
cord-022353-q2k2krnm	1044	23	a	a	DT
cord-022353-q2k2krnm	1044	24	maximum	maximum	NN
cord-022353-q2k2krnm	1044	25	of	of	IN
cord-022353-q2k2krnm	1045	1	40	40	CD
cord-022353-q2k2krnm	1045	2	~tg	~tg	NNS
cord-022353-q2k2krnm	1045	3	/	/	SYM
cord-022353-q2k2krnm	1045	4	dl	dl	NN
cord-022353-q2k2krnm	1045	5	well	well	RB
cord-022353-q2k2krnm	1045	6	into	into	IN
cord-022353-q2k2krnm	1045	7	the	the	DT
cord-022353-q2k2krnm	1045	8	dark	dark	JJ
cord-022353-q2k2krnm	1045	9	period	period	NN
cord-022353-q2k2krnm	1046	1	(	(	-LRB-
cord-022353-q2k2krnm	1046	2	Scheving	Scheving	NNP
cord-022353-q2k2krnm	1046	3	et	et	FW
cord-022353-q2k2krnm	1046	4	al	al	NNP
cord-022353-q2k2krnm	1046	5	.	.	.
cord-022353-q2k2krnm	1046	6	1983	1983	CD
cord-022353-q2k2krnm	1046	7	)	)	-RRB-
cord-022353-q2k2krnm	1046	8	.	.	.
cord-022353-q2k2krnm	1047	1	The	the	DT
cord-022353-q2k2krnm	1047	2	length	length	NN
cord-022353-q2k2krnm	1047	3	of	of	IN
cord-022353-q2k2krnm	1047	4	the	the	DT
cord-022353-q2k2krnm	1047	5	dark	dark	JJ
cord-022353-q2k2krnm	1047	6	cycle	cycle	NN
cord-022353-q2k2krnm	1047	7	was	be	VBD
cord-022353-q2k2krnm	1047	8	different	different	JJ
cord-022353-q2k2krnm	1047	9	in	in	IN
cord-022353-q2k2krnm	1047	10	each	each	DT
cord-022353-q2k2krnm	1047	11	study	study	NN
cord-022353-q2k2krnm	1047	12	.	.	.
cord-022353-q2k2krnm	1048	1	It	-PRON-	PRP
cord-022353-q2k2krnm	1048	2	may	may	MD
cord-022353-q2k2krnm	1048	3	be	be	VB
cord-022353-q2k2krnm	1048	4	measured	measure	VBN
cord-022353-q2k2krnm	1048	5	using	use	VBG
cord-022353-q2k2krnm	1048	6	radioimmunoassay	radioimmunoassay	JJ
cord-022353-q2k2krnm	1048	7	,	,	,
cord-022353-q2k2krnm	1048	8	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1048	9	,	,	,
cord-022353-q2k2krnm	1048	10	or	or	CC
cord-022353-q2k2krnm	1048	11	fluorometric	fluorometric	JJ
cord-022353-q2k2krnm	1048	12	assay	assay	NN
cord-022353-q2k2krnm	1048	13	in	in	IN
cord-022353-q2k2krnm	1048	14	mouse	mouse	NN
cord-022353-q2k2krnm	1048	15	serum	serum	NN
cord-022353-q2k2krnm	1048	16	or	or	CC
cord-022353-q2k2krnm	1048	17	plasma	plasma	NN
cord-022353-q2k2krnm	1048	18	.	.	.
cord-022353-q2k2krnm	1049	1	Corticosterone	Corticosterone	NNP
cord-022353-q2k2krnm	1049	2	circulates	circulate	VBZ
cord-022353-q2k2krnm	1049	3	in	in	IN
cord-022353-q2k2krnm	1049	4	both	both	CC
cord-022353-q2k2krnm	1049	5	free	free	JJ
cord-022353-q2k2krnm	1049	6	and	and	CC
cord-022353-q2k2krnm	1049	7	protein	protein	NN
cord-022353-q2k2krnm	1049	8	bound	bind	VBN
cord-022353-q2k2krnm	1049	9	forms	form	NNS
cord-022353-q2k2krnm	1049	10	.	.	.
cord-022353-q2k2krnm	1050	1	In	in	IN
cord-022353-q2k2krnm	1050	2	the	the	DT
cord-022353-q2k2krnm	1050	3	mouse	mouse	NN
cord-022353-q2k2krnm	1050	4	,	,	,
cord-022353-q2k2krnm	1050	5	greater	great	JJR
cord-022353-q2k2krnm	1050	6	than	than	IN
cord-022353-q2k2krnm	1050	7	99	99	CD
cord-022353-q2k2krnm	1050	8	%	%	NN
cord-022353-q2k2krnm	1050	9	circulates	circulate	NNS
cord-022353-q2k2krnm	1050	10	bound	bind	VBN
cord-022353-q2k2krnm	1050	11	to	to	IN
cord-022353-q2k2krnm	1050	12	cortisol	cortisol	NN
cord-022353-q2k2krnm	1050	13	-	-	HYPH
cord-022353-q2k2krnm	1050	14	binding	bind	VBG
cord-022353-q2k2krnm	1050	15	globulin	globulin	NN
cord-022353-q2k2krnm	1050	16	(	(	-LRB-
cord-022353-q2k2krnm	1050	17	CBG	CBG	NNP
cord-022353-q2k2krnm	1050	18	)	)	-RRB-
cord-022353-q2k2krnm	1050	19	and	and	CC
cord-022353-q2k2krnm	1050	20	albumin	albumin	NN
cord-022353-q2k2krnm	1050	21	.	.	.
cord-022353-q2k2krnm	1051	1	The	the	DT
cord-022353-q2k2krnm	1051	2	diurnal	diurnal	JJ
cord-022353-q2k2krnm	1051	3	variation	variation	NN
cord-022353-q2k2krnm	1051	4	in	in	IN
cord-022353-q2k2krnm	1051	5	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1051	6	levels	level	NNS
cord-022353-q2k2krnm	1051	7	is	be	VBZ
cord-022353-q2k2krnm	1051	8	paralleled	parallel	VBN
cord-022353-q2k2krnm	1051	9	by	by	IN
cord-022353-q2k2krnm	1051	10	the	the	DT
cord-022353-q2k2krnm	1051	11	diurnal	diurnal	JJ
cord-022353-q2k2krnm	1051	12	pattern	pattern	NN
cord-022353-q2k2krnm	1051	13	of	of	IN
cord-022353-q2k2krnm	1051	14	CBG	CBG	NNP
cord-022353-q2k2krnm	1051	15	.	.	.
cord-022353-q2k2krnm	1052	1	Urinary	urinary	JJ
cord-022353-q2k2krnm	1052	2	and	and	CC
cord-022353-q2k2krnm	1052	3	salivary	salivary	NN
cord-022353-q2k2krnm	1052	4	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1052	5	is	be	VBZ
cord-022353-q2k2krnm	1052	6	derived	derive	VBN
cord-022353-q2k2krnm	1052	7	only	only	RB
cord-022353-q2k2krnm	1052	8	from	from	IN
cord-022353-q2k2krnm	1052	9	the	the	DT
cord-022353-q2k2krnm	1052	10	free	free	JJ
cord-022353-q2k2krnm	1052	11	plasma	plasma	NN
cord-022353-q2k2krnm	1052	12	fraction	fraction	NN
cord-022353-q2k2krnm	1052	13	.	.	.
cord-022353-q2k2krnm	1053	1	Corticosterone	Corticosterone	NNP
cord-022353-q2k2krnm	1053	2	synthesis	synthesis	NN
cord-022353-q2k2krnm	1053	3	and	and	CC
cord-022353-q2k2krnm	1053	4	secretion	secretion	NN
cord-022353-q2k2krnm	1053	5	may	may	MD
cord-022353-q2k2krnm	1053	6	be	be	VB
cord-022353-q2k2krnm	1053	7	influenced	influence	VBN
cord-022353-q2k2krnm	1053	8	by	by	IN
cord-022353-q2k2krnm	1053	9	many	many	JJ
cord-022353-q2k2krnm	1053	10	drugs	drug	NNS
cord-022353-q2k2krnm	1053	11	(	(	-LRB-
cord-022353-q2k2krnm	1053	12	Woodman	Woodman	NNP
cord-022353-q2k2krnm	1053	13	1997	1997	CD
cord-022353-q2k2krnm	1053	14	)	)	-RRB-
cord-022353-q2k2krnm	1053	15	.	.	.
cord-022353-q2k2krnm	1054	1	Measurements	measurement	NNS
cord-022353-q2k2krnm	1054	2	of	of	IN
cord-022353-q2k2krnm	1054	3	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1054	4	in	in	IN
cord-022353-q2k2krnm	1054	5	unrestrained	unrestrained	JJ
cord-022353-q2k2krnm	1054	6	mice	mouse	NNS
cord-022353-q2k2krnm	1054	7	using	use	VBG
cord-022353-q2k2krnm	1054	8	indwelling	indwell	VBG
cord-022353-q2k2krnm	1054	9	catheters	catheter	NNS
cord-022353-q2k2krnm	1054	10	have	have	VBP
cord-022353-q2k2krnm	1054	11	elucidated	elucidate	VBN
cord-022353-q2k2krnm	1054	12	the	the	DT
cord-022353-q2k2krnm	1054	13	necessity	necessity	NN
cord-022353-q2k2krnm	1054	14	of	of	IN
cord-022353-q2k2krnm	1054	15	eliminating	eliminate	VBG
cord-022353-q2k2krnm	1054	16	stress	stress	NN
cord-022353-q2k2krnm	1054	17	for	for	IN
cord-022353-q2k2krnm	1054	18	accurate	accurate	JJ
cord-022353-q2k2krnm	1054	19	interpretation	interpretation	NN
cord-022353-q2k2krnm	1054	20	of	of	IN
cord-022353-q2k2krnm	1054	21	data	datum	NNS
cord-022353-q2k2krnm	1054	22	(	(	-LRB-
cord-022353-q2k2krnm	1054	23	MacLeod	MacLeod	NNP
cord-022353-q2k2krnm	1054	24	and	and	CC
cord-022353-q2k2krnm	1054	25	Shapiro	Shapiro	NNP
cord-022353-q2k2krnm	1054	26	1988	1988	CD
cord-022353-q2k2krnm	1054	27	)	)	-RRB-
cord-022353-q2k2krnm	1054	28	.	.	.
cord-022353-q2k2krnm	1055	1	Both	both	DT
cord-022353-q2k2krnm	1055	2	handling	handle	VBG
cord-022353-q2k2krnm	1055	3	and	and	CC
cord-022353-q2k2krnm	1055	4	crowding	crowd	VBG
cord-022353-q2k2krnm	1055	5	laboratory	laboratory	NN
cord-022353-q2k2krnm	1055	6	mice	mouse	NNS
cord-022353-q2k2krnm	1055	7	can	can	MD
cord-022353-q2k2krnm	1055	8	cause	cause	VB
cord-022353-q2k2krnm	1055	9	elevations	elevation	NNS
cord-022353-q2k2krnm	1055	10	in	in	IN
cord-022353-q2k2krnm	1055	11	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1055	12	(	(	-LRB-
cord-022353-q2k2krnm	1055	13	Balcombe	Balcombe	NNP
cord-022353-q2k2krnm	1055	14	et	et	FW
cord-022353-q2k2krnm	1055	15	al	al	NNP
cord-022353-q2k2krnm	1055	16	.	.	.
cord-022353-q2k2krnm	1056	1	2004	2004	CD
cord-022353-q2k2krnm	1056	2	;	;	:
cord-022353-q2k2krnm	1056	3	Fullwood	Fullwood	NNP
cord-022353-q2k2krnm	1056	4	et	et	NNP
cord-022353-q2k2krnm	1056	5	al	al	NNP
cord-022353-q2k2krnm	1056	6	.	.	NNP
cord-022353-q2k2krnm	1056	7	1998	1998	CD
cord-022353-q2k2krnm	1056	8	)	)	-RRB-
cord-022353-q2k2krnm	1056	9	.	.	.
cord-022353-q2k2krnm	1057	1	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1057	2	ob	ob	NNP
cord-022353-q2k2krnm	1057	3	/	/	SYM
cord-022353-q2k2krnm	1057	4	ob	ob	NNP
cord-022353-q2k2krnm	1057	5	mice	mouse	NNS
cord-022353-q2k2krnm	1057	6	have	have	VBP
cord-022353-q2k2krnm	1057	7	elevated	elevate	VBN
cord-022353-q2k2krnm	1057	8	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1057	9	levels	level	NNS
cord-022353-q2k2krnm	1057	10	that	that	WDT
cord-022353-q2k2krnm	1057	11	increase	increase	VBP
cord-022353-q2k2krnm	1057	12	markedly	markedly	RB
cord-022353-q2k2krnm	1057	13	after	after	IN
cord-022353-q2k2krnm	1057	14	40	40	CD
cord-022353-q2k2krnm	1057	15	weeks	week	NNS
cord-022353-q2k2krnm	1057	16	of	of	IN
cord-022353-q2k2krnm	1057	17	age	age	NN
cord-022353-q2k2krnm	1057	18	,	,	,
cord-022353-q2k2krnm	1057	19	preceding	precede	VBG
cord-022353-q2k2krnm	1057	20	elevations	elevation	NNS
cord-022353-q2k2krnm	1057	21	in	in	IN
cord-022353-q2k2krnm	1057	22	serum	serum	NN
cord-022353-q2k2krnm	1057	23	glucose	glucose	NN
cord-022353-q2k2krnm	1058	1	(	(	-LRB-
cord-022353-q2k2krnm	1058	2	Garthwaite	Garthwaite	NNP
cord-022353-q2k2krnm	1058	3	et	et	FW
cord-022353-q2k2krnm	1058	4	al	al	NNP
cord-022353-q2k2krnm	1058	5	.	.	.
cord-022353-q2k2krnm	1058	6	1980	1980	CD
cord-022353-q2k2krnm	1058	7	)	)	-RRB-
cord-022353-q2k2krnm	1058	8	.	.	.
cord-022353-q2k2krnm	1059	1	Lean	Lean	NNP
cord-022353-q2k2krnm	1059	2	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1059	3	controls	control	NNS
cord-022353-q2k2krnm	1059	4	had	have	VBD
cord-022353-q2k2krnm	1059	5	lower	low	JJR
cord-022353-q2k2krnm	1059	6	serum	serum	NN
cord-022353-q2k2krnm	1059	7	concentrations	concentration	NNS
cord-022353-q2k2krnm	1059	8	of	of	IN
cord-022353-q2k2krnm	1059	9	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1059	10	that	that	WDT
cord-022353-q2k2krnm	1059	11	declined	decline	VBD
cord-022353-q2k2krnm	1059	12	between	between	IN
cord-022353-q2k2krnm	1059	13	5	5	CD
cord-022353-q2k2krnm	1059	14	and	and	CC
cord-022353-q2k2krnm	1059	15	20	20	CD
cord-022353-q2k2krnm	1059	16	weeks	week	NNS
cord-022353-q2k2krnm	1059	17	of	of	IN
cord-022353-q2k2krnm	1059	18	age	age	NN
cord-022353-q2k2krnm	1059	19	.	.	.
cord-022353-q2k2krnm	1060	1	Food	food	NN
cord-022353-q2k2krnm	1060	2	restriction	restriction	NN
cord-022353-q2k2krnm	1060	3	(	(	-LRB-
cord-022353-q2k2krnm	1060	4	to	to	IN
cord-022353-q2k2krnm	1060	5	60	60	CD
cord-022353-q2k2krnm	1060	6	%	%	NN
cord-022353-q2k2krnm	1060	7	of	of	IN
cord-022353-q2k2krnm	1060	8	ad	ad	NN
cord-022353-q2k2krnm	1060	9	libitum	libitum	FW
cord-022353-q2k2krnm	1060	10	)	)	-RRB-
cord-022353-q2k2krnm	1060	11	profoundly	profoundly	RB
cord-022353-q2k2krnm	1060	12	affects	affect	VBZ
cord-022353-q2k2krnm	1060	13	the	the	DT
cord-022353-q2k2krnm	1060	14	diurnal	diurnal	JJ
cord-022353-q2k2krnm	1060	15	increase	increase	NN
cord-022353-q2k2krnm	1060	16	in	in	IN
cord-022353-q2k2krnm	1060	17	plasma	plasma	NN
cord-022353-q2k2krnm	1060	18	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1060	19	in	in	IN
cord-022353-q2k2krnm	1060	20	mice	mouse	NNS
cord-022353-q2k2krnm	1060	21	.	.	.
cord-022353-q2k2krnm	1061	1	At	at	IN
cord-022353-q2k2krnm	1061	2	20:00	20:00	CD
cord-022353-q2k2krnm	1061	3	hours	hour	NNS
cord-022353-q2k2krnm	1061	4	(	(	-LRB-
cord-022353-q2k2krnm	1061	5	8	8	CD
cord-022353-q2k2krnm	1061	6	P.M.	p.m.	NN
cord-022353-q2k2krnm	1061	7	)	)	-RRB-
cord-022353-q2k2krnm	1061	8	,	,	,
cord-022353-q2k2krnm	1061	9	the	the	DT
cord-022353-q2k2krnm	1061	10	daily	daily	JJ
cord-022353-q2k2krnm	1061	11	maximum	maximum	NN
cord-022353-q2k2krnm	1061	12	in	in	IN
cord-022353-q2k2krnm	1061	13	this	this	DT
cord-022353-q2k2krnm	1061	14	study	study	NN
cord-022353-q2k2krnm	1061	15	,	,	,
cord-022353-q2k2krnm	1061	16	food	food	NN
cord-022353-q2k2krnm	1061	17	restricted	restrict	VBN
cord-022353-q2k2krnm	1062	1	BALB	BALB	NNP
cord-022353-q2k2krnm	1062	2	/	/	SYM
cord-022353-q2k2krnm	1062	3	c	c	NN
cord-022353-q2k2krnm	1062	4	mice	mouse	NNS
cord-022353-q2k2krnm	1062	5	had	have	VBD
cord-022353-q2k2krnm	1062	6	300	300	CD
cord-022353-q2k2krnm	1062	7	%	%	NN
cord-022353-q2k2krnm	1062	8	more	more	JJR
cord-022353-q2k2krnm	1062	9	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1062	10	compared	compare	VBN
cord-022353-q2k2krnm	1062	11	to	to	IN
cord-022353-q2k2krnm	1062	12	controls	control	NNS
cord-022353-q2k2krnm	1062	13	.	.	.
cord-022353-q2k2krnm	1063	1	These	these	DT
cord-022353-q2k2krnm	1063	2	mice	mouse	NNS
cord-022353-q2k2krnm	1063	3	also	also	RB
cord-022353-q2k2krnm	1063	4	had	have	VBD
cord-022353-q2k2krnm	1063	5	significantly	significantly	RB
cord-022353-q2k2krnm	1063	6	reduced	reduce	VBN
cord-022353-q2k2krnm	1063	7	thymic	thymic	JJ
cord-022353-q2k2krnm	1063	8	weight	weight	NN
cord-022353-q2k2krnm	1063	9	and	and	CC
cord-022353-q2k2krnm	1063	10	inflammation	inflammation	NN
cord-022353-q2k2krnm	1063	11	in	in	IN
cord-022353-q2k2krnm	1063	12	response	response	NN
cord-022353-q2k2krnm	1063	13	to	to	IN
cord-022353-q2k2krnm	1063	14	the	the	DT
cord-022353-q2k2krnm	1063	15	injection	injection	NN
cord-022353-q2k2krnm	1063	16	of	of	IN
cord-022353-q2k2krnm	1063	17	carrageenan	carrageenan	NN
cord-022353-q2k2krnm	1063	18	subcutaneously	subcutaneously	RB
cord-022353-q2k2krnm	1063	19	.	.	.
cord-022353-q2k2krnm	1064	1	The	the	DT
cord-022353-q2k2krnm	1064	2	authors	author	NNS
cord-022353-q2k2krnm	1064	3	report	report	VBP
cord-022353-q2k2krnm	1064	4	that	that	IN
cord-022353-q2k2krnm	1064	5	the	the	DT
cord-022353-q2k2krnm	1064	6	magnitude	magnitude	NN
cord-022353-q2k2krnm	1064	7	of	of	IN
cord-022353-q2k2krnm	1064	8	carrageenan	carrageenan	NN
cord-022353-q2k2krnm	1064	9	-	-	HYPH
cord-022353-q2k2krnm	1064	10	induced	induce	VBN
cord-022353-q2k2krnm	1064	11	inflammation	inflammation	NN
cord-022353-q2k2krnm	1064	12	fluctuates	fluctuate	VBZ
cord-022353-q2k2krnm	1064	13	with	with	IN
cord-022353-q2k2krnm	1064	14	a	a	DT
cord-022353-q2k2krnm	1064	15	diurnal	diurnal	JJ
cord-022353-q2k2krnm	1064	16	trough	trough	NN
cord-022353-q2k2krnm	1064	17	,	,	,
cord-022353-q2k2krnm	1064	18	which	which	WDT
cord-022353-q2k2krnm	1064	19	coincides	coincide	VBZ
cord-022353-q2k2krnm	1064	20	with	with	IN
cord-022353-q2k2krnm	1064	21	peak	peak	JJ
cord-022353-q2k2krnm	1064	22	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1064	23	levels	level	NNS
cord-022353-q2k2krnm	1064	24	(	(	-LRB-
cord-022353-q2k2krnm	1064	25	Klebanov	Klebanov	NNP
cord-022353-q2k2krnm	1064	26	et	et	FW
cord-022353-q2k2krnm	1064	27	al	al	NNP
cord-022353-q2k2krnm	1064	28	.	.	NNP
cord-022353-q2k2krnm	1064	29	1995	1995	CD
cord-022353-q2k2krnm	1064	30	)	)	-RRB-
cord-022353-q2k2krnm	1064	31	.	.	.
cord-022353-q2k2krnm	1065	1	Corticosterone	Corticosterone	NNP
cord-022353-q2k2krnm	1065	2	is	be	VBZ
cord-022353-q2k2krnm	1065	3	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1065	4	in	in	IN
cord-022353-q2k2krnm	1065	5	response	response	NN
cord-022353-q2k2krnm	1065	6	to	to	IN
cord-022353-q2k2krnm	1065	7	ACTH	ACTH	NNP
cord-022353-q2k2krnm	1065	8	,	,	,
cord-022353-q2k2krnm	1065	9	which	which	WDT
cord-022353-q2k2krnm	1065	10	is	be	VBZ
cord-022353-q2k2krnm	1065	11	made	make	VBN
cord-022353-q2k2krnm	1065	12	in	in	IN
cord-022353-q2k2krnm	1065	13	the	the	DT
cord-022353-q2k2krnm	1065	14	anterior	anterior	JJ
cord-022353-q2k2krnm	1065	15	pituitary	pituitary	NN
cord-022353-q2k2krnm	1065	16	.	.	.
cord-022353-q2k2krnm	1066	1	ACTH	ACTH	NNP
cord-022353-q2k2krnm	1066	2	release	release	NN
cord-022353-q2k2krnm	1066	3	is	be	VBZ
cord-022353-q2k2krnm	1066	4	episodic	episodic	JJ
cord-022353-q2k2krnm	1066	5	(	(	-LRB-
cord-022353-q2k2krnm	1066	6	not	not	RB
cord-022353-q2k2krnm	1066	7	at	at	IN
cord-022353-q2k2krnm	1066	8	fixed	fix	VBN
cord-022353-q2k2krnm	1066	9	intervals	interval	NNS
cord-022353-q2k2krnm	1066	10	)	)	-RRB-
cord-022353-q2k2krnm	1066	11	and	and	CC
cord-022353-q2k2krnm	1066	12	does	do	VBZ
cord-022353-q2k2krnm	1066	13	not	not	RB
cord-022353-q2k2krnm	1066	14	involve	involve	VB
cord-022353-q2k2krnm	1066	15	steroid	steroid	NN
cord-022353-q2k2krnm	1066	16	feedback	feedback	NN
cord-022353-q2k2krnm	1066	17	.	.	.
cord-022353-q2k2krnm	1067	1	ACTH	ACTH	NNP
cord-022353-q2k2krnm	1067	2	concentration	concentration	NN
cord-022353-q2k2krnm	1067	3	peaks	peak	NNS
cord-022353-q2k2krnm	1067	4	in	in	IN
cord-022353-q2k2krnm	1067	5	the	the	DT
cord-022353-q2k2krnm	1067	6	early	early	JJ
cord-022353-q2k2krnm	1067	7	evening	evening	NN
cord-022353-q2k2krnm	1067	8	in	in	IN
cord-022353-q2k2krnm	1067	9	mice	mouse	NNS
cord-022353-q2k2krnm	1067	10	and	and	CC
cord-022353-q2k2krnm	1067	11	can	can	MD
cord-022353-q2k2krnm	1067	12	be	be	VB
cord-022353-q2k2krnm	1067	13	reversed	reverse	VBN
cord-022353-q2k2krnm	1067	14	by	by	IN
cord-022353-q2k2krnm	1067	15	reversing	reverse	VBG
cord-022353-q2k2krnm	1067	16	the	the	DT
cord-022353-q2k2krnm	1067	17	light	light	JJ
cord-022353-q2k2krnm	1067	18	cycle	cycle	NN
cord-022353-q2k2krnm	1067	19	.	.	.
cord-022353-q2k2krnm	1068	1	ACTH	ACTH	NNP
cord-022353-q2k2krnm	1068	2	is	be	VBZ
cord-022353-q2k2krnm	1068	3	highly	highly	RB
cord-022353-q2k2krnm	1068	4	conserved	conserve	VBN
cord-022353-q2k2krnm	1068	5	with	with	IN
cord-022353-q2k2krnm	1068	6	the	the	DT
cord-022353-q2k2krnm	1068	7	mouse	mouse	NN
cord-022353-q2k2krnm	1068	8	ACTH	ACTH	NNP
cord-022353-q2k2krnm	1068	9	differing	differ	VBG
cord-022353-q2k2krnm	1068	10	from	from	IN
cord-022353-q2k2krnm	1068	11	human	human	NN
cord-022353-q2k2krnm	1068	12	by	by	IN
cord-022353-q2k2krnm	1068	13	only	only	RB
cord-022353-q2k2krnm	1068	14	two	two	CD
cord-022353-q2k2krnm	1068	15	amino	amino	NN
cord-022353-q2k2krnm	1068	16	acid	acid	NN
cord-022353-q2k2krnm	1068	17	residues	residue	NNS
cord-022353-q2k2krnm	1068	18	.	.	.
cord-022353-q2k2krnm	1069	1	RIA	RIA	NNP
cord-022353-q2k2krnm	1069	2	may	may	MD
cord-022353-q2k2krnm	1069	3	be	be	VB
cord-022353-q2k2krnm	1069	4	used	use	VBN
cord-022353-q2k2krnm	1069	5	to	to	TO
cord-022353-q2k2krnm	1069	6	measure	measure	VB
cord-022353-q2k2krnm	1069	7	ACTH	ACTH	NNP
cord-022353-q2k2krnm	1069	8	in	in	IN
cord-022353-q2k2krnm	1069	9	the	the	DT
cord-022353-q2k2krnm	1069	10	mouse	mouse	NN
cord-022353-q2k2krnm	1069	11	(	(	-LRB-
cord-022353-q2k2krnm	1069	12	daily	daily	JJ
cord-022353-q2k2krnm	1069	13	levels	level	NNS
cord-022353-q2k2krnm	1069	14	vary	vary	VBP
cord-022353-q2k2krnm	1069	15	from	from	IN
cord-022353-q2k2krnm	1069	16	2.6	2.6	CD
cord-022353-q2k2krnm	1069	17	-	-	SYM
cord-022353-q2k2krnm	1069	18	5.4	5.4	CD
cord-022353-q2k2krnm	1069	19	ng	ng	NNP
cord-022353-q2k2krnm	1069	20	/	/	SYM
cord-022353-q2k2krnm	1069	21	ml	ml	NN
cord-022353-q2k2krnm	1069	22	)	)	-RRB-
cord-022353-q2k2krnm	1069	23	and	and	CC
cord-022353-q2k2krnm	1069	24	to	to	TO
cord-022353-q2k2krnm	1069	25	demonstrate	demonstrate	VB
cord-022353-q2k2krnm	1069	26	rhythmic	rhythmic	JJ
cord-022353-q2k2krnm	1069	27	cycling	cycling	NN
cord-022353-q2k2krnm	1069	28	.	.	.
cord-022353-q2k2krnm	1070	1	Samples	sample	NNS
cord-022353-q2k2krnm	1070	2	must	must	MD
cord-022353-q2k2krnm	1070	3	be	be	VB
cord-022353-q2k2krnm	1070	4	collected	collect	VBN
cord-022353-q2k2krnm	1070	5	at	at	IN
cord-022353-q2k2krnm	1070	6	5-to	5-to	CD
cord-022353-q2k2krnm	1070	7	30-minute	30-minute	CD
cord-022353-q2k2krnm	1070	8	intervals	interval	NNS
cord-022353-q2k2krnm	1070	9	.	.	.
cord-022353-q2k2krnm	1071	1	Commercial	Commercial	NNP
cord-022353-q2k2krnm	1071	2	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1071	3	kits	kit	NNS
cord-022353-q2k2krnm	1071	4	for	for	IN
cord-022353-q2k2krnm	1071	5	ACTH	ACTH	NNP
cord-022353-q2k2krnm	1071	6	are	be	VBP
cord-022353-q2k2krnm	1071	7	also	also	RB
cord-022353-q2k2krnm	1071	8	available	available	JJ
cord-022353-q2k2krnm	1071	9	(	(	-LRB-
cord-022353-q2k2krnm	1071	10	Quimby	Quimby	NNP
cord-022353-q2k2krnm	1071	11	1999b	1999b	CD
cord-022353-q2k2krnm	1071	12	)	)	-RRB-
cord-022353-q2k2krnm	1072	1	KO	KO	NNP
cord-022353-q2k2krnm	1072	2	mice	mouse	NNS
cord-022353-q2k2krnm	1072	3	incapable	incapable	JJ
cord-022353-q2k2krnm	1072	4	of	of	IN
cord-022353-q2k2krnm	1072	5	synthesizing	synthesize	VBG
cord-022353-q2k2krnm	1072	6	corticotrophin	corticotrophin	NNP
cord-022353-q2k2krnm	1072	7	releasing	release	VBG
cord-022353-q2k2krnm	1072	8	hormone	hormone	NN
cord-022353-q2k2krnm	1072	9	or	or	CC
cord-022353-q2k2krnm	1072	10	ACTH	ACTH	NNP
cord-022353-q2k2krnm	1072	11	may	may	MD
cord-022353-q2k2krnm	1072	12	require	require	VB
cord-022353-q2k2krnm	1072	13	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1072	14	supplementation	supplementation	NN
cord-022353-q2k2krnm	1072	15	in	in	IN
cord-022353-q2k2krnm	1072	16	drinking	drinking	NN
cord-022353-q2k2krnm	1072	17	water	water	NN
cord-022353-q2k2krnm	1072	18	and	and	CC
cord-022353-q2k2krnm	1072	19	are	be	VBP
cord-022353-q2k2krnm	1072	20	particularly	particularly	RB
cord-022353-q2k2krnm	1072	21	susceptible	susceptible	JJ
cord-022353-q2k2krnm	1072	22	to	to	IN
cord-022353-q2k2krnm	1072	23	hypoglycemia	hypoglycemia	NN
cord-022353-q2k2krnm	1072	24	during	during	IN
cord-022353-q2k2krnm	1072	25	fasting	fast	VBG
cord-022353-q2k2krnm	1072	26	.	.	.
cord-022353-q2k2krnm	1073	1	Fetuses	fetus	NNS
cord-022353-q2k2krnm	1073	2	of	of	IN
cord-022353-q2k2krnm	1073	3	homozygous	homozygous	JJ
cord-022353-q2k2krnm	1073	4	KO	KO	NNP
cord-022353-q2k2krnm	1073	5	CRH	CRH	NNP
cord-022353-q2k2krnm	1073	6	null	null	JJ
cord-022353-q2k2krnm	1073	7	mothers	mother	NNS
cord-022353-q2k2krnm	1073	8	must	must	MD
cord-022353-q2k2krnm	1073	9	be	be	VB
cord-022353-q2k2krnm	1073	10	supplemented	supplement	VBN
cord-022353-q2k2krnm	1073	11	from	from	IN
cord-022353-q2k2krnm	1073	12	gestational	gestational	JJ
cord-022353-q2k2krnm	1073	13	day	day	NN
cord-022353-q2k2krnm	1073	14	12	12	CD
cord-022353-q2k2krnm	1073	15	to	to	IN
cord-022353-q2k2krnm	1073	16	weaning	wean	VBG
cord-022353-q2k2krnm	1073	17	with	with	IN
cord-022353-q2k2krnm	1073	18	30	30	CD
cord-022353-q2k2krnm	1073	19	mg	mg	NNP
cord-022353-q2k2krnm	1073	20	/	/	SYM
cord-022353-q2k2krnm	1073	21	ml	ml	NN
cord-022353-q2k2krnm	1073	22	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1073	23	in	in	IN
cord-022353-q2k2krnm	1073	24	drinking	drinking	NN
cord-022353-q2k2krnm	1073	25	water	water	NN
cord-022353-q2k2krnm	1074	1	(	(	-LRB-
cord-022353-q2k2krnm	1074	2	Mugila	Mugila	NNP
cord-022353-q2k2krnm	1074	3	et	et	FW
cord-022353-q2k2krnm	1074	4	al	al	NNP
cord-022353-q2k2krnm	1074	5	.	.	NNP
cord-022353-q2k2krnm	1074	6	1995	1995	CD
cord-022353-q2k2krnm	1074	7	)	)	-RRB-
cord-022353-q2k2krnm	1074	8	.	.	.
cord-022353-q2k2krnm	1075	1	Oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1075	2	gene	gene	NN
cord-022353-q2k2krnm	1076	1	KO	KO	NNP
cord-022353-q2k2krnm	1076	2	mice	mouse	NNS
cord-022353-q2k2krnm	1076	3	respond	respond	VBP
cord-022353-q2k2krnm	1076	4	to	to	IN
cord-022353-q2k2krnm	1076	5	a	a	DT
cord-022353-q2k2krnm	1076	6	psychogenic	psychogenic	JJ
cord-022353-q2k2krnm	1076	7	stressor	stressor	NN
cord-022353-q2k2krnm	1076	8	with	with	IN
cord-022353-q2k2krnm	1076	9	more	more	JJR
cord-022353-q2k2krnm	1076	10	anxiety	anxiety	NN
cord-022353-q2k2krnm	1076	11	-	-	HYPH
cord-022353-q2k2krnm	1076	12	related	relate	VBN
cord-022353-q2k2krnm	1076	13	behavior	behavior	NN
cord-022353-q2k2krnm	1076	14	and	and	CC
cord-022353-q2k2krnm	1076	15	more	more	JJR
cord-022353-q2k2krnm	1076	16	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1076	17	production	production	NN
cord-022353-q2k2krnm	1077	1	(	(	-LRB-
cord-022353-q2k2krnm	1077	2	Amico	Amico	NNP
cord-022353-q2k2krnm	1077	3	et	et	FW
cord-022353-q2k2krnm	1077	4	al	al	NNP
cord-022353-q2k2krnm	1077	5	.	.	.
cord-022353-q2k2krnm	1077	6	2004	2004	CD
cord-022353-q2k2krnm	1077	7	)	)	-RRB-
cord-022353-q2k2krnm	1077	8	.	.	.
cord-022353-q2k2krnm	1078	1	LH	LH	NNP
cord-022353-q2k2krnm	1078	2	promotes	promote	VBZ
cord-022353-q2k2krnm	1078	3	follicular	follicular	JJ
cord-022353-q2k2krnm	1078	4	development	development	NN
cord-022353-q2k2krnm	1078	5	,	,	,
cord-022353-q2k2krnm	1078	6	increases	increase	VBZ
cord-022353-q2k2krnm	1078	7	estradiol	estradiol	NN
cord-022353-q2k2krnm	1078	8	secretion	secretion	NN
cord-022353-q2k2krnm	1078	9	in	in	IN
cord-022353-q2k2krnm	1078	10	the	the	DT
cord-022353-q2k2krnm	1078	11	preovulatory	preovulatory	NNP
cord-022353-q2k2krnm	1078	12	follicle	follicle	NN
cord-022353-q2k2krnm	1078	13	,	,	,
cord-022353-q2k2krnm	1078	14	causes	cause	VBZ
cord-022353-q2k2krnm	1078	15	follicular	follicular	JJ
cord-022353-q2k2krnm	1078	16	rupture	rupture	NN
cord-022353-q2k2krnm	1078	17	,	,	,
cord-022353-q2k2krnm	1078	18	converts	convert	VBZ
cord-022353-q2k2krnm	1078	19	the	the	DT
cord-022353-q2k2krnm	1078	20	preovulatory	preovulatory	JJ
cord-022353-q2k2krnm	1078	21	follicle	follicle	NN
cord-022353-q2k2krnm	1078	22	into	into	IN
cord-022353-q2k2krnm	1078	23	a	a	DT
cord-022353-q2k2krnm	1078	24	corpus	corpus	NN
cord-022353-q2k2krnm	1078	25	luteum	luteum	NN
cord-022353-q2k2krnm	1078	26	,	,	,
cord-022353-q2k2krnm	1078	27	increases	increase	VBZ
cord-022353-q2k2krnm	1078	28	progesterone	progesterone	NN
cord-022353-q2k2krnm	1078	29	production	production	NN
cord-022353-q2k2krnm	1078	30	by	by	IN
cord-022353-q2k2krnm	1078	31	the	the	DT
cord-022353-q2k2krnm	1078	32	corpus	corpus	NNP
cord-022353-q2k2krnm	1078	33	luteum	luteum	NN
cord-022353-q2k2krnm	1078	34	,	,	,
cord-022353-q2k2krnm	1078	35	and	and	CC
cord-022353-q2k2krnm	1078	36	,	,	,
cord-022353-q2k2krnm	1078	37	in	in	IN
cord-022353-q2k2krnm	1078	38	the	the	DT
cord-022353-q2k2krnm	1078	39	male	male	NN
cord-022353-q2k2krnm	1078	40	,	,	,
cord-022353-q2k2krnm	1078	41	increases	increase	VBZ
cord-022353-q2k2krnm	1078	42	production	production	NN
cord-022353-q2k2krnm	1078	43	of	of	IN
cord-022353-q2k2krnm	1078	44	testosterone	testosterone	NN
cord-022353-q2k2krnm	1078	45	from	from	IN
cord-022353-q2k2krnm	1078	46	Leydig	Leydig	NNP
cord-022353-q2k2krnm	1078	47	cells	cell	NNS
cord-022353-q2k2krnm	1078	48	(	(	-LRB-
cord-022353-q2k2krnm	1078	49	Woodman	Woodman	NNP
cord-022353-q2k2krnm	1078	50	1997	1997	CD
cord-022353-q2k2krnm	1078	51	)	)	-RRB-
cord-022353-q2k2krnm	1078	52	.	.	.
cord-022353-q2k2krnm	1079	1	LH	LH	NNP
cord-022353-q2k2krnm	1079	2	is	be	VBZ
cord-022353-q2k2krnm	1079	3	a	a	DT
cord-022353-q2k2krnm	1079	4	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	1079	5	composed	compose	VBN
cord-022353-q2k2krnm	1079	6	of	of	IN
cord-022353-q2k2krnm	1079	7	t~-and	t~-and	CD
cord-022353-q2k2krnm	1079	8	~-chains	~-chain	NNS
cord-022353-q2k2krnm	1079	9	.	.	.
cord-022353-q2k2krnm	1080	1	The	the	DT
cord-022353-q2k2krnm	1080	2	amino	amino	NN
cord-022353-q2k2krnm	1080	3	acid	acid	NN
cord-022353-q2k2krnm	1080	4	sequence	sequence	NN
cord-022353-q2k2krnm	1080	5	of	of	IN
cord-022353-q2k2krnm	1080	6	the	the	DT
cord-022353-q2k2krnm	1080	7	t~-chain	t~-chain	NN
cord-022353-q2k2krnm	1080	8	is	be	VBZ
cord-022353-q2k2krnm	1080	9	identical	identical	JJ
cord-022353-q2k2krnm	1080	10	to	to	IN
cord-022353-q2k2krnm	1080	11	that	that	DT
cord-022353-q2k2krnm	1080	12	of	of	IN
cord-022353-q2k2krnm	1080	13	follicle	follicle	NN
cord-022353-q2k2krnm	1080	14	-	-	HYPH
cord-022353-q2k2krnm	1080	15	stimulating	stimulate	VBG
cord-022353-q2k2krnm	1080	16	hormone	hormone	NN
cord-022353-q2k2krnm	1080	17	(	(	-LRB-
cord-022353-q2k2krnm	1080	18	FSH	fsh	NN
cord-022353-q2k2krnm	1080	19	)	)	-RRB-
cord-022353-q2k2krnm	1080	20	;	;	:
cord-022353-q2k2krnm	1080	21	however	however	RB
cord-022353-q2k2krnm	1080	22	,	,	,
cord-022353-q2k2krnm	1080	23	the	the	DT
cord-022353-q2k2krnm	1080	24	~l	~l	NNP
cord-022353-q2k2krnm	1080	25	-	-	HYPH
cord-022353-q2k2krnm	1080	26	chain	chain	NN
cord-022353-q2k2krnm	1080	27	is	be	VBZ
cord-022353-q2k2krnm	1080	28	specific	specific	JJ
cord-022353-q2k2krnm	1080	29	and	and	CC
cord-022353-q2k2krnm	1080	30	confers	confer	VBZ
cord-022353-q2k2krnm	1080	31	the	the	DT
cord-022353-q2k2krnm	1080	32	receptor	receptor	NN
cord-022353-q2k2krnm	1080	33	binding	bind	VBG
cord-022353-q2k2krnm	1080	34	properties	property	NNS
cord-022353-q2k2krnm	1080	35	on	on	IN
cord-022353-q2k2krnm	1080	36	the	the	DT
cord-022353-q2k2krnm	1080	37	hormone	hormone	NN
cord-022353-q2k2krnm	1080	38	.	.	.
cord-022353-q2k2krnm	1081	1	A	a	DT
cord-022353-q2k2krnm	1081	2	homologous	homologous	JJ
cord-022353-q2k2krnm	1081	3	RIA	RIA	NNP
cord-022353-q2k2krnm	1081	4	for	for	IN
cord-022353-q2k2krnm	1081	5	rat	rat	NN
cord-022353-q2k2krnm	1081	6	LH	LH	NNP
cord-022353-q2k2krnm	1081	7	using	use	VBG
cord-022353-q2k2krnm	1081	8	antisera	antisera	NN
cord-022353-q2k2krnm	1081	9	to	to	IN
cord-022353-q2k2krnm	1081	10	rat	rat	NN
cord-022353-q2k2krnm	1081	11	LH	LH	NNP
cord-022353-q2k2krnm	1081	12	and	and	CC
cord-022353-q2k2krnm	1081	13	purified	purify	VBN
cord-022353-q2k2krnm	1081	14	rat	rat	NN
cord-022353-q2k2krnm	1081	15	LH	LH	NNP
cord-022353-q2k2krnm	1081	16	has	have	VBZ
cord-022353-q2k2krnm	1081	17	been	be	VBN
cord-022353-q2k2krnm	1081	18	employed	employ	VBN
cord-022353-q2k2krnm	1081	19	to	to	TO
cord-022353-q2k2krnm	1081	20	measure	measure	VB
cord-022353-q2k2krnm	1081	21	LH	LH	NNP
cord-022353-q2k2krnm	1081	22	in	in	IN
cord-022353-q2k2krnm	1081	23	mice	mouse	NNS
cord-022353-q2k2krnm	1081	24	(	(	-LRB-
cord-022353-q2k2krnm	1081	25	Quimby	Quimby	NNP
cord-022353-q2k2krnm	1081	26	1999b	1999b	CD
cord-022353-q2k2krnm	1081	27	)	)	-RRB-
cord-022353-q2k2krnm	1081	28	.	.	.
cord-022353-q2k2krnm	1082	1	LH	LH	NNP
cord-022353-q2k2krnm	1082	2	and	and	CC
cord-022353-q2k2krnm	1082	3	folliclestimulating	folliclestimulate	VBG
cord-022353-q2k2krnm	1082	4	hormone	hormone	NN
cord-022353-q2k2krnm	1082	5	(	(	-LRB-
cord-022353-q2k2krnm	1082	6	FSH	FSH	NNP
cord-022353-q2k2krnm	1082	7	)	)	-RRB-
cord-022353-q2k2krnm	1082	8	are	be	VBP
cord-022353-q2k2krnm	1082	9	secreted	secrete	VBN
cord-022353-q2k2krnm	1082	10	by	by	IN
cord-022353-q2k2krnm	1082	11	the	the	DT
cord-022353-q2k2krnm	1082	12	same	same	JJ
cord-022353-q2k2krnm	1082	13	anterior	anterior	JJ
cord-022353-q2k2krnm	1082	14	pituitary	pituitary	JJ
cord-022353-q2k2krnm	1082	15	cell	cell	NN
cord-022353-q2k2krnm	1082	16	in	in	IN
cord-022353-q2k2krnm	1082	17	response	response	NN
cord-022353-q2k2krnm	1082	18	to	to	IN
cord-022353-q2k2krnm	1082	19	stimulation	stimulation	NN
cord-022353-q2k2krnm	1082	20	by	by	IN
cord-022353-q2k2krnm	1082	21	gonadotrophinreleasing	gonadotrophinrelease	VBG
cord-022353-q2k2krnm	1082	22	hormone	hormone	NN
cord-022353-q2k2krnm	1082	23	(	(	-LRB-
cord-022353-q2k2krnm	1082	24	GnRH	GnRH	NNP
cord-022353-q2k2krnm	1082	25	)	)	-RRB-
cord-022353-q2k2krnm	1082	26	,	,	,
cord-022353-q2k2krnm	1082	27	which	which	WDT
cord-022353-q2k2krnm	1082	28	is	be	VBZ
cord-022353-q2k2krnm	1082	29	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1082	30	in	in	IN
cord-022353-q2k2krnm	1082	31	the	the	DT
cord-022353-q2k2krnm	1082	32	hypothalamus	hypothalamus	NN
cord-022353-q2k2krnm	1082	33	.	.	.
cord-022353-q2k2krnm	1083	1	GnRH	GnRH	NNP
cord-022353-q2k2krnm	1083	2	is	be	VBZ
cord-022353-q2k2krnm	1083	3	identical	identical	JJ
cord-022353-q2k2krnm	1083	4	in	in	IN
cord-022353-q2k2krnm	1083	5	mouse	mouse	NN
cord-022353-q2k2krnm	1083	6	and	and	CC
cord-022353-q2k2krnm	1083	7	humans	human	NNS
cord-022353-q2k2krnm	1083	8	,	,	,
cord-022353-q2k2krnm	1083	9	and	and	CC
cord-022353-q2k2krnm	1083	10	its	-PRON-	PRP$
cord-022353-q2k2krnm	1083	11	differential	differential	JJ
cord-022353-q2k2krnm	1083	12	stimulatory	stimulatory	JJ
cord-022353-q2k2krnm	1083	13	effect	effect	NN
cord-022353-q2k2krnm	1083	14	on	on	IN
cord-022353-q2k2krnm	1083	15	gonadotropes	gonadotropes	NNP
cord-022353-q2k2krnm	1083	16	,	,	,
cord-022353-q2k2krnm	1083	17	producing	produce	VBG
cord-022353-q2k2krnm	1083	18	FSH	fsh	NN
cord-022353-q2k2krnm	1083	19	or	or	CC
cord-022353-q2k2krnm	1083	20	LH	LH	NNP
cord-022353-q2k2krnm	1083	21	is	be	VBZ
cord-022353-q2k2krnm	1083	22	controlled	control	VBN
cord-022353-q2k2krnm	1083	23	through	through	IN
cord-022353-q2k2krnm	1083	24	GnRH	gnrh	JJ
cord-022353-q2k2krnm	1083	25	pulse	pulse	NN
cord-022353-q2k2krnm	1083	26	frequency	frequency	NN
cord-022353-q2k2krnm	1083	27	.	.	.
cord-022353-q2k2krnm	1084	1	Pulsatile	pulsatile	JJ
cord-022353-q2k2krnm	1084	2	secretion	secretion	NN
cord-022353-q2k2krnm	1084	3	of	of	IN
cord-022353-q2k2krnm	1084	4	LH	LH	NNP
cord-022353-q2k2krnm	1084	5	leads	lead	VBZ
cord-022353-q2k2krnm	1084	6	to	to	IN
cord-022353-q2k2krnm	1084	7	great	great	JJ
cord-022353-q2k2krnm	1084	8	variations	variation	NNS
cord-022353-q2k2krnm	1084	9	in	in	IN
cord-022353-q2k2krnm	1084	10	blood	blood	NN
cord-022353-q2k2krnm	1084	11	concentration	concentration	NN
cord-022353-q2k2krnm	1084	12	.	.	.
cord-022353-q2k2krnm	1085	1	In	in	IN
cord-022353-q2k2krnm	1085	2	female	female	JJ
cord-022353-q2k2krnm	1085	3	mice	mouse	NNS
cord-022353-q2k2krnm	1085	4	,	,	,
cord-022353-q2k2krnm	1085	5	there	there	EX
cord-022353-q2k2krnm	1085	6	is	be	VBZ
cord-022353-q2k2krnm	1085	7	a	a	DT
cord-022353-q2k2krnm	1085	8	10-to	10-to	CD
cord-022353-q2k2krnm	1085	9	25-fold	25-fold	CD
cord-022353-q2k2krnm	1085	10	increase	increase	NN
cord-022353-q2k2krnm	1085	11	in	in	IN
cord-022353-q2k2krnm	1085	12	basal	basal	NN
cord-022353-q2k2krnm	1085	13	LH	LH	NNP
cord-022353-q2k2krnm	1085	14	levels	level	NNS
cord-022353-q2k2krnm	1085	15	in	in	IN
cord-022353-q2k2krnm	1085	16	the	the	DT
cord-022353-q2k2krnm	1085	17	afternoon	afternoon	NN
cord-022353-q2k2krnm	1085	18	of	of	IN
cord-022353-q2k2krnm	1085	19	proestrus	proestrus	NNP
cord-022353-q2k2krnm	1085	20	.	.	.
cord-022353-q2k2krnm	1086	1	In	in	IN
cord-022353-q2k2krnm	1086	2	a	a	DT
cord-022353-q2k2krnm	1086	3	study	study	NN
cord-022353-q2k2krnm	1086	4	comparing	compare	VBG
cord-022353-q2k2krnm	1086	5	young	young	JJ
cord-022353-q2k2krnm	1086	6	cycling	cycling	NN
cord-022353-q2k2krnm	1086	7	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1086	8	female	female	JJ
cord-022353-q2k2krnm	1086	9	mice	mouse	NNS
cord-022353-q2k2krnm	1086	10	to	to	IN
cord-022353-q2k2krnm	1086	11	old	old	JJ
cord-022353-q2k2krnm	1086	12	females	female	NNS
cord-022353-q2k2krnm	1086	13	(	(	-LRB-
cord-022353-q2k2krnm	1086	14	40	40	CD
cord-022353-q2k2krnm	1086	15	%	%	NN
cord-022353-q2k2krnm	1086	16	of	of	IN
cord-022353-q2k2krnm	1086	17	which	which	WDT
cord-022353-q2k2krnm	1086	18	not	not	RB
cord-022353-q2k2krnm	1086	19	cycling	cycle	VBG
cord-022353-q2k2krnm	1086	20	)	)	-RRB-
cord-022353-q2k2krnm	1086	21	,	,	,
cord-022353-q2k2krnm	1086	22	Flurkey	Flurkey	NNP
cord-022353-q2k2krnm	1086	23	et	et	NNP
cord-022353-q2k2krnm	1086	24	al	al	NNP
cord-022353-q2k2krnm	1086	25	.	.	.
cord-022353-q2k2krnm	1087	1	(	(	-LRB-
cord-022353-q2k2krnm	1087	2	1982	1982	CD
cord-022353-q2k2krnm	1087	3	)	)	-RRB-
cord-022353-q2k2krnm	1087	4	found	find	VBD
cord-022353-q2k2krnm	1087	5	lower	low	JJR
cord-022353-q2k2krnm	1087	6	LH	LH	NNP
cord-022353-q2k2krnm	1087	7	levels	level	NNS
cord-022353-q2k2krnm	1087	8	in	in	IN
cord-022353-q2k2krnm	1087	9	the	the	DT
cord-022353-q2k2krnm	1087	10	older	old	JJR
cord-022353-q2k2krnm	1087	11	group	group	NN
cord-022353-q2k2krnm	1087	12	and	and	CC
cord-022353-q2k2krnm	1087	13	a	a	DT
cord-022353-q2k2krnm	1087	14	more	more	RBR
cord-022353-q2k2krnm	1087	15	rapid	rapid	JJ
cord-022353-q2k2krnm	1087	16	rise	rise	NN
cord-022353-q2k2krnm	1087	17	in	in	IN
cord-022353-q2k2krnm	1087	18	LH	LH	NNP
cord-022353-q2k2krnm	1087	19	among	among	IN
cord-022353-q2k2krnm	1087	20	younger	young	JJR
cord-022353-q2k2krnm	1087	21	cycling	cycling	NN
cord-022353-q2k2krnm	1087	22	mice	mouse	NNS
cord-022353-q2k2krnm	1087	23	.	.	.
cord-022353-q2k2krnm	1088	1	These	these	DT
cord-022353-q2k2krnm	1088	2	authors	author	NNS
cord-022353-q2k2krnm	1088	3	found	find	VBD
cord-022353-q2k2krnm	1088	4	that	that	IN
cord-022353-q2k2krnm	1088	5	reproductive	reproductive	JJ
cord-022353-q2k2krnm	1088	6	failure	failure	NN
cord-022353-q2k2krnm	1088	7	in	in	IN
cord-022353-q2k2krnm	1088	8	male	male	JJ
cord-022353-q2k2krnm	1088	9	mice	mouse	NNS
cord-022353-q2k2krnm	1088	10	correlated	correlate	VBN
cord-022353-q2k2krnm	1088	11	with	with	IN
cord-022353-q2k2krnm	1088	12	the	the	DT
cord-022353-q2k2krnm	1088	13	loss	loss	NN
cord-022353-q2k2krnm	1088	14	of	of	IN
cord-022353-q2k2krnm	1088	15	episodic	episodic	JJ
cord-022353-q2k2krnm	1088	16	release	release	NN
cord-022353-q2k2krnm	1088	17	of	of	IN
cord-022353-q2k2krnm	1088	18	LH	LH	NNP
cord-022353-q2k2krnm	1088	19	.	.	.
cord-022353-q2k2krnm	1089	1	Female	female	JJ
cord-022353-q2k2krnm	1089	2	homozygous	homozygous	JJ
cord-022353-q2k2krnm	1089	3	KO	KO	NNP
cord-022353-q2k2krnm	1089	4	mice	mouse	NNS
cord-022353-q2k2krnm	1089	5	lacking	lack	VBG
cord-022353-q2k2krnm	1089	6	the	the	DT
cord-022353-q2k2krnm	1089	7	gene	gene	NN
cord-022353-q2k2krnm	1089	8	for	for	IN
cord-022353-q2k2krnm	1089	9	the	the	DT
cord-022353-q2k2krnm	1089	10	immediate	immediate	JJ
cord-022353-q2k2krnm	1089	11	early	early	JJ
cord-022353-q2k2krnm	1089	12	transcription	transcription	NN
cord-022353-q2k2krnm	1089	13	factor	factor	NN
cord-022353-q2k2krnm	1089	14	NGFI	NGFI	NNP
cord-022353-q2k2krnm	1090	1	-A	-A	NNS
cord-022353-q2k2krnm	1090	2	were	be	VBD
cord-022353-q2k2krnm	1090	3	infertile	infertile	JJ
cord-022353-q2k2krnm	1090	4	secondary	secondary	JJ
cord-022353-q2k2krnm	1090	5	to	to	IN
cord-022353-q2k2krnm	1090	6	LH-[3	lh-[3	JJ
cord-022353-q2k2krnm	1090	7	deficiency	deficiency	NN
cord-022353-q2k2krnm	1090	8	.	.	.
cord-022353-q2k2krnm	1091	1	Although	although	IN
cord-022353-q2k2krnm	1091	2	ovaries	ovary	NNS
cord-022353-q2k2krnm	1091	3	from	from	IN
cord-022353-q2k2krnm	1091	4	these	these	DT
cord-022353-q2k2krnm	1091	5	mice	mouse	NNS
cord-022353-q2k2krnm	1091	6	had	have	VBD
cord-022353-q2k2krnm	1091	7	a	a	DT
cord-022353-q2k2krnm	1091	8	similar	similar	JJ
cord-022353-q2k2krnm	1091	9	number	number	NN
cord-022353-q2k2krnm	1091	10	of	of	IN
cord-022353-q2k2krnm	1091	11	follicles	follicle	NNS
cord-022353-q2k2krnm	1091	12	,	,	,
cord-022353-q2k2krnm	1091	13	they	-PRON-	PRP
cord-022353-q2k2krnm	1091	14	lacked	lack	VBD
cord-022353-q2k2krnm	1091	15	corpora	corpora	NN
cord-022353-q2k2krnm	1091	16	lutea	lutea	NN
cord-022353-q2k2krnm	1091	17	(	(	-LRB-
cord-022353-q2k2krnm	1091	18	Lee	Lee	NNP
cord-022353-q2k2krnm	1091	19	et	et	NNP
cord-022353-q2k2krnm	1091	20	al	al	NNP
cord-022353-q2k2krnm	1091	21	.	.	.
cord-022353-q2k2krnm	1091	22	1996	1996	CD
cord-022353-q2k2krnm	1091	23	)	)	-RRB-
cord-022353-q2k2krnm	1091	24	.	.	.
cord-022353-q2k2krnm	1092	1	Basal	basal	NN
cord-022353-q2k2krnm	1092	2	levels	level	NNS
cord-022353-q2k2krnm	1092	3	of	of	IN
cord-022353-q2k2krnm	1092	4	serum	serum	NN
cord-022353-q2k2krnm	1092	5	progesterone	progesterone	NN
cord-022353-q2k2krnm	1092	6	were	be	VBD
cord-022353-q2k2krnm	1092	7	lower	low	JJR
cord-022353-q2k2krnm	1092	8	in	in	IN
cord-022353-q2k2krnm	1092	9	NGFI-	NGFI-	NNP
cord-022353-q2k2krnm	1093	1	A	a	DT
cord-022353-q2k2krnm	1093	2	females	female	NNS
cord-022353-q2k2krnm	1093	3	(	(	-LRB-
cord-022353-q2k2krnm	1093	4	6.3	6.3	CD
cord-022353-q2k2krnm	1093	5	+	+	SYM
cord-022353-q2k2krnm	1093	6	2.4	2.4	CD
cord-022353-q2k2krnm	1093	7	ng	ng	NN
cord-022353-q2k2krnm	1093	8	/	/	SYM
cord-022353-q2k2krnm	1093	9	ml	ml	NN
cord-022353-q2k2krnm	1093	10	)	)	-RRB-
cord-022353-q2k2krnm	1093	11	compared	compare	VBN
cord-022353-q2k2krnm	1093	12	to	to	IN
cord-022353-q2k2krnm	1093	13	wild	wild	JJ
cord-022353-q2k2krnm	1093	14	type	type	NN
cord-022353-q2k2krnm	1093	15	(	(	-LRB-
cord-022353-q2k2krnm	1093	16	11.3	11.3	CD
cord-022353-q2k2krnm	1093	17	+	+	CC
cord-022353-q2k2krnm	1093	18	_	_	NN
cord-022353-q2k2krnm	1093	19	3.6	3.6	CD
cord-022353-q2k2krnm	1093	20	ng	ng	NN
cord-022353-q2k2krnm	1093	21	/	/	SYM
cord-022353-q2k2krnm	1093	22	ml	ml	NN
cord-022353-q2k2krnm	1093	23	)	)	-RRB-
cord-022353-q2k2krnm	1093	24	,	,	,
cord-022353-q2k2krnm	1093	25	whereas	whereas	IN
cord-022353-q2k2krnm	1093	26	serum	serum	NN
cord-022353-q2k2krnm	1093	27	estradiol	estradiol	NN
cord-022353-q2k2krnm	1093	28	levels	level	NNS
cord-022353-q2k2krnm	1093	29	were	be	VBD
cord-022353-q2k2krnm	1093	30	similar	similar	JJ
cord-022353-q2k2krnm	1093	31	in	in	IN
cord-022353-q2k2krnm	1093	32	deficient	deficient	JJ
cord-022353-q2k2krnm	1093	33	(	(	-LRB-
cord-022353-q2k2krnm	1093	34	50.7	50.7	CD
cord-022353-q2k2krnm	1093	35	+	+	SYM
cord-022353-q2k2krnm	1093	36	36.9	36.9	CD
cord-022353-q2k2krnm	1093	37	pg	pg	NNP
cord-022353-q2k2krnm	1093	38	/	/	SYM
cord-022353-q2k2krnm	1093	39	ml	ml	NNP
cord-022353-q2k2krnm	1093	40	)	)	-RRB-
cord-022353-q2k2krnm	1093	41	and	and	CC
cord-022353-q2k2krnm	1093	42	wild	wild	JJ
cord-022353-q2k2krnm	1093	43	-	-	HYPH
cord-022353-q2k2krnm	1093	44	type	type	NN
cord-022353-q2k2krnm	1093	45	(	(	-LRB-
cord-022353-q2k2krnm	1093	46	52.0	52.0	CD
cord-022353-q2k2krnm	1093	47	_	_	NN
cord-022353-q2k2krnm	1093	48	+	+	SYM
cord-022353-q2k2krnm	1093	49	34.3	34.3	CD
cord-022353-q2k2krnm	1093	50	pg	pg	NNP
cord-022353-q2k2krnm	1093	51	/	/	SYM
cord-022353-q2k2krnm	1093	52	ml	ml	NN
cord-022353-q2k2krnm	1093	53	)	)	-RRB-
cord-022353-q2k2krnm	1093	54	mice	mouse	NNS
cord-022353-q2k2krnm	1093	55	.	.	.
cord-022353-q2k2krnm	1094	1	Decreased	decrease	VBN
cord-022353-q2k2krnm	1094	2	amounts	amount	NNS
cord-022353-q2k2krnm	1094	3	of	of	IN
cord-022353-q2k2krnm	1094	4	mRNA	mrna	NN
cord-022353-q2k2krnm	1094	5	encoding	encoding	NN
cord-022353-q2k2krnm	1094	6	LH-[3	LH-[3	NNP
cord-022353-q2k2krnm	1094	7	,	,	,
cord-022353-q2k2krnm	1094	8	but	but	CC
cord-022353-q2k2krnm	1094	9	not	not	RB
cord-022353-q2k2krnm	1094	10	FSH-[3	FSH-[3	NNP
cord-022353-q2k2krnm	1094	11	,	,	,
cord-022353-q2k2krnm	1094	12	were	be	VBD
cord-022353-q2k2krnm	1094	13	observed	observe	VBN
cord-022353-q2k2krnm	1094	14	in	in	IN
cord-022353-q2k2krnm	1094	15	NGFI	NGFI	NNP
cord-022353-q2k2krnm	1094	16	-	-	HYPH
cord-022353-q2k2krnm	1094	17	A	a	NN
cord-022353-q2k2krnm	1094	18	-	-	HYPH
cord-022353-q2k2krnm	1094	19	deficient	deficient	JJ
cord-022353-q2k2krnm	1094	20	mice	mice	NN
cord-022353-q2k2krnm	1094	21	;	;	:
cord-022353-q2k2krnm	1094	22	no	no	DT
cord-022353-q2k2krnm	1094	23	changes	change	NNS
cord-022353-q2k2krnm	1094	24	were	be	VBD
cord-022353-q2k2krnm	1094	25	observed	observe	VBN
cord-022353-q2k2krnm	1094	26	in	in	IN
cord-022353-q2k2krnm	1094	27	mRNA	mRNA	NNP
cord-022353-q2k2krnm	1094	28	levels	level	NNS
cord-022353-q2k2krnm	1094	29	for	for	IN
cord-022353-q2k2krnm	1094	30	PRL	PRL	NNP
cord-022353-q2k2krnm	1094	31	or	or	CC
cord-022353-q2k2krnm	1094	32	GnRH	gnrh	JJ
cord-022353-q2k2krnm	1094	33	receptor	receptor	NN
cord-022353-q2k2krnm	1094	34	between	between	IN
cord-022353-q2k2krnm	1094	35	deficient	deficient	JJ
cord-022353-q2k2krnm	1094	36	and	and	CC
cord-022353-q2k2krnm	1094	37	wild	wild	JJ
cord-022353-q2k2krnm	1094	38	-	-	HYPH
cord-022353-q2k2krnm	1094	39	type	type	NN
cord-022353-q2k2krnm	1094	40	mice	mouse	NNS
cord-022353-q2k2krnm	1094	41	.	.	.
cord-022353-q2k2krnm	1095	1	An	an	DT
cord-022353-q2k2krnm	1095	2	ovariectomy	ovariectomy	NN
cord-022353-q2k2krnm	1095	3	normally	normally	RB
cord-022353-q2k2krnm	1095	4	removes	remove	VBZ
cord-022353-q2k2krnm	1095	5	gonadal	gonadal	JJ
cord-022353-q2k2krnm	1095	6	feedback	feedback	NN
cord-022353-q2k2krnm	1095	7	inhibition	inhibition	NN
cord-022353-q2k2krnm	1095	8	,	,	,
cord-022353-q2k2krnm	1095	9	allowing	allow	VBG
cord-022353-q2k2krnm	1095	10	for	for	IN
cord-022353-q2k2krnm	1095	11	increased	increase	VBN
cord-022353-q2k2krnm	1095	12	amounts	amount	NNS
cord-022353-q2k2krnm	1095	13	of	of	IN
cord-022353-q2k2krnm	1095	14	LH-~	lh-~	NN
cord-022353-q2k2krnm	1095	15	and	and	CC
cord-022353-q2k2krnm	1095	16	FSH-[3	FSH-[3	NNP
cord-022353-q2k2krnm	1095	17	in	in	IN
cord-022353-q2k2krnm	1095	18	the	the	DT
cord-022353-q2k2krnm	1095	19	pituitary	pituitary	NN
cord-022353-q2k2krnm	1095	20	;	;	:
cord-022353-q2k2krnm	1095	21	however	however	RB
cord-022353-q2k2krnm	1095	22	,	,	,
cord-022353-q2k2krnm	1095	23	ovariectomy	ovariectomy	NN
cord-022353-q2k2krnm	1095	24	of	of	IN
cord-022353-q2k2krnm	1095	25	NGFI	NGFI	NNP
cord-022353-q2k2krnm	1095	26	-	-	:
cord-022353-q2k2krnm	1095	27	A	a	DT
cord-022353-q2k2krnm	1095	28	deficient	deficient	JJ
cord-022353-q2k2krnm	1095	29	female	female	JJ
cord-022353-q2k2krnm	1095	30	mice	mouse	NNS
cord-022353-q2k2krnm	1095	31	lead	lead	VBP
cord-022353-q2k2krnm	1095	32	to	to	IN
cord-022353-q2k2krnm	1095	33	an	an	DT
cord-022353-q2k2krnm	1095	34	increase	increase	NN
cord-022353-q2k2krnm	1095	35	in	in	IN
cord-022353-q2k2krnm	1095	36	FSH-~	FSH-~	NNP
cord-022353-q2k2krnm	1095	37	only	only	RB
cord-022353-q2k2krnm	1095	38	.	.	.
cord-022353-q2k2krnm	1096	1	Homozygous	Homozygous	NNP
cord-022353-q2k2krnm	1096	2	NGFI-	NGFI-	NNP
cord-022353-q2k2krnm	1097	1	A	a	DT
cord-022353-q2k2krnm	1097	2	deficient	deficient	JJ
cord-022353-q2k2krnm	1097	3	males	male	NNS
cord-022353-q2k2krnm	1097	4	did	do	VBD
cord-022353-q2k2krnm	1097	5	make	make	VB
cord-022353-q2k2krnm	1097	6	lower	low	JJR
cord-022353-q2k2krnm	1097	7	amounts	amount	NNS
cord-022353-q2k2krnm	1097	8	of	of	IN
cord-022353-q2k2krnm	1097	9	LH-~	lh-~	NN
cord-022353-q2k2krnm	1097	10	compared	compare	VBN
cord-022353-q2k2krnm	1097	11	to	to	IN
cord-022353-q2k2krnm	1097	12	wild	wild	JJ
cord-022353-q2k2krnm	1097	13	-	-	HYPH
cord-022353-q2k2krnm	1097	14	type	type	NN
cord-022353-q2k2krnm	1097	15	males	male	NNS
cord-022353-q2k2krnm	1097	16	,	,	,
cord-022353-q2k2krnm	1097	17	but	but	CC
cord-022353-q2k2krnm	1097	18	they	-PRON-	PRP
cord-022353-q2k2krnm	1097	19	made	make	VBD
cord-022353-q2k2krnm	1097	20	significantly	significantly	RB
cord-022353-q2k2krnm	1097	21	more	more	RBR
cord-022353-q2k2krnm	1097	22	LH-[3	LH-[3	JJR
cord-022353-q2k2krnm	1097	23	than	than	IN
cord-022353-q2k2krnm	1097	24	did	do	VBD
cord-022353-q2k2krnm	1097	25	NGFI	NGFI	NNP
cord-022353-q2k2krnm	1097	26	-	-	HYPH
cord-022353-q2k2krnm	1097	27	A	a	NN
cord-022353-q2k2krnm	1097	28	-	-	HYPH
cord-022353-q2k2krnm	1097	29	deficient	deficient	JJ
cord-022353-q2k2krnm	1097	30	females	female	NNS
cord-022353-q2k2krnm	1097	31	.	.	.
cord-022353-q2k2krnm	1098	1	The	the	DT
cord-022353-q2k2krnm	1098	2	levels	level	NNS
cord-022353-q2k2krnm	1098	3	of	of	IN
cord-022353-q2k2krnm	1098	4	LH	LH	NNP
cord-022353-q2k2krnm	1098	5	in	in	IN
cord-022353-q2k2krnm	1098	6	males	male	NNS
cord-022353-q2k2krnm	1098	7	appeared	appear	VBD
cord-022353-q2k2krnm	1098	8	to	to	TO
cord-022353-q2k2krnm	1098	9	be	be	VB
cord-022353-q2k2krnm	1098	10	sufficient	sufficient	JJ
cord-022353-q2k2krnm	1098	11	for	for	IN
cord-022353-q2k2krnm	1098	12	fertility	fertility	NN
cord-022353-q2k2krnm	1098	13	,	,	,
cord-022353-q2k2krnm	1098	14	and	and	CC
cord-022353-q2k2krnm	1098	15	they	-PRON-	PRP
cord-022353-q2k2krnm	1098	16	had	have	VBD
cord-022353-q2k2krnm	1098	17	normal	normal	JJ
cord-022353-q2k2krnm	1098	18	serum	serum	NN
cord-022353-q2k2krnm	1098	19	testosterone	testosterone	NN
cord-022353-q2k2krnm	1098	20	levels	level	NNS
cord-022353-q2k2krnm	1098	21	.	.	.
cord-022353-q2k2krnm	1099	1	These	these	DT
cord-022353-q2k2krnm	1099	2	results	result	NNS
cord-022353-q2k2krnm	1099	3	suggest	suggest	VBP
cord-022353-q2k2krnm	1099	4	that	that	IN
cord-022353-q2k2krnm	1099	5	NGFI	NGFI	NNP
cord-022353-q2k2krnm	1099	6	-	-	HYPH
cord-022353-q2k2krnm	1099	7	A	A	NNP
cord-022353-q2k2krnm	1099	8	acts	act	NNS
cord-022353-q2k2krnm	1099	9	synergistically	synergistically	RB
cord-022353-q2k2krnm	1099	10	with	with	IN
cord-022353-q2k2krnm	1099	11	transcription	transcription	NN
cord-022353-q2k2krnm	1099	12	factor	factor	NN
cord-022353-q2k2krnm	1099	13	SF-1	SF-1	NNP
cord-022353-q2k2krnm	1099	14	to	to	TO
cord-022353-q2k2krnm	1099	15	regulate	regulate	VB
cord-022353-q2k2krnm	1099	16	the	the	DT
cord-022353-q2k2krnm	1099	17	promoter	promoter	NN
cord-022353-q2k2krnm	1099	18	for	for	IN
cord-022353-q2k2krnm	1099	19	LH-[3	lh-[3	JJ
cord-022353-q2k2krnm	1099	20	gene	gene	NN
cord-022353-q2k2krnm	1099	21	expression	expression	NN
cord-022353-q2k2krnm	1099	22	.	.	.
cord-022353-q2k2krnm	1100	1	The	the	DT
cord-022353-q2k2krnm	1100	2	simultaneous	simultaneous	JJ
cord-022353-q2k2krnm	1100	3	activation	activation	NN
cord-022353-q2k2krnm	1100	4	of	of	IN
cord-022353-q2k2krnm	1100	5	both	both	CC
cord-022353-q2k2krnm	1100	6	SF-1	SF-1	NNP
cord-022353-q2k2krnm	1100	7	and	and	CC
cord-022353-q2k2krnm	1100	8	NGFI	NGFI	NNP
cord-022353-q2k2krnm	1100	9	-	-	HYPH
cord-022353-q2k2krnm	1100	10	A	a	NN
cord-022353-q2k2krnm	1100	11	by	by	IN
cord-022353-q2k2krnm	1100	12	GnRH	GnRH	NNP
cord-022353-q2k2krnm	1100	13	appears	appear	VBZ
cord-022353-q2k2krnm	1100	14	to	to	TO
cord-022353-q2k2krnm	1100	15	confer	confer	VB
cord-022353-q2k2krnm	1100	16	the	the	DT
cord-022353-q2k2krnm	1100	17	specificity	specificity	NN
cord-022353-q2k2krnm	1100	18	of	of	IN
cord-022353-q2k2krnm	1100	19	LH-~	lh-~	NN
cord-022353-q2k2krnm	1100	20	synthesis	synthesis	NN
cord-022353-q2k2krnm	1100	21	.	.	.
cord-022353-q2k2krnm	1101	1	Female	female	JJ
cord-022353-q2k2krnm	1101	2	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1101	3	mice	mouse	NNS
cord-022353-q2k2krnm	1101	4	overexpressing	overexpresse	VBG
cord-022353-q2k2krnm	1101	5	LH	LH	NNP
cord-022353-q2k2krnm	1101	6	are	be	VBP
cord-022353-q2k2krnm	1101	7	anovulatory	anovulatory	JJ
cord-022353-q2k2krnm	1101	8	,	,	,
cord-022353-q2k2krnm	1101	9	develop	develop	VB
cord-022353-q2k2krnm	1101	10	granulosa	granulosa	JJ
cord-022353-q2k2krnm	1101	11	cell	cell	NN
cord-022353-q2k2krnm	1101	12	tumors	tumor	NNS
cord-022353-q2k2krnm	1101	13	,	,	,
cord-022353-q2k2krnm	1101	14	and	and	CC
cord-022353-q2k2krnm	1101	15	undergo	undergo	VB
cord-022353-q2k2krnm	1101	16	precocious	precocious	JJ
cord-022353-q2k2krnm	1101	17	puberty	puberty	NN
cord-022353-q2k2krnm	1102	1	(	(	-LRB-
cord-022353-q2k2krnm	1102	2	Mann	Mann	NNP
cord-022353-q2k2krnm	1102	3	et	et	NNP
cord-022353-q2k2krnm	1102	4	al	al	NNP
cord-022353-q2k2krnm	1102	5	.	.	NNP
cord-022353-q2k2krnm	1102	6	2003	2003	CD
cord-022353-q2k2krnm	1102	7	)	)	-RRB-
cord-022353-q2k2krnm	1102	8	.	.	.
cord-022353-q2k2krnm	1103	1	Excellent	excellent	JJ
cord-022353-q2k2krnm	1103	2	reviews	review	NNS
cord-022353-q2k2krnm	1103	3	detailing	detail	VBG
cord-022353-q2k2krnm	1103	4	the	the	DT
cord-022353-q2k2krnm	1103	5	use	use	NN
cord-022353-q2k2krnm	1103	6	of	of	IN
cord-022353-q2k2krnm	1103	7	transgenic	transgenic	NN
cord-022353-q2k2krnm	1103	8	and	and	CC
cord-022353-q2k2krnm	1103	9	KO	KO	NNP
cord-022353-q2k2krnm	1103	10	mice	mouse	NNS
cord-022353-q2k2krnm	1103	11	in	in	IN
cord-022353-q2k2krnm	1103	12	elucidating	elucidate	VBG
cord-022353-q2k2krnm	1103	13	the	the	DT
cord-022353-q2k2krnm	1103	14	secretion	secretion	NN
cord-022353-q2k2krnm	1103	15	and	and	CC
cord-022353-q2k2krnm	1103	16	function	function	NN
cord-022353-q2k2krnm	1103	17	of	of	IN
cord-022353-q2k2krnm	1103	18	LH	LH	NNP
cord-022353-q2k2krnm	1103	19	have	have	VBP
cord-022353-q2k2krnm	1103	20	been	be	VBN
cord-022353-q2k2krnm	1103	21	published	publish	VBN
cord-022353-q2k2krnm	1104	1	(	(	-LRB-
cord-022353-q2k2krnm	1104	2	Bums	bum	NNS
cord-022353-q2k2krnm	1104	3	and	and	CC
cord-022353-q2k2krnm	1104	4	Matzuk	Matzuk	NNP
cord-022353-q2k2krnm	1104	5	2002	2002	CD
cord-022353-q2k2krnm	1104	6	;	;	:
cord-022353-q2k2krnm	1104	7	Huhtaniemi	Huhtaniemi	NNP
cord-022353-q2k2krnm	1104	8	et	et	NNP
cord-022353-q2k2krnm	1104	9	al	al	NNP
cord-022353-q2k2krnm	1104	10	.	.	.
cord-022353-q2k2krnm	1104	11	2002	2002	CD
cord-022353-q2k2krnm	1104	12	;	;	:
cord-022353-q2k2krnm	1105	1	Wells	Wells	NNP
cord-022353-q2k2krnm	1105	2	and	and	CC
cord-022353-q2k2krnm	1105	3	Murphy	Murphy	NNP
cord-022353-q2k2krnm	1105	4	2003	2003	CD
cord-022353-q2k2krnm	1105	5	)	)	-RRB-
cord-022353-q2k2krnm	1105	6	.	.	.
cord-022353-q2k2krnm	1106	1	FSH	FSH	NNP
cord-022353-q2k2krnm	1106	2	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	1106	3	the	the	DT
cord-022353-q2k2krnm	1106	4	growth	growth	NN
cord-022353-q2k2krnm	1106	5	and	and	CC
cord-022353-q2k2krnm	1106	6	maturation	maturation	NN
cord-022353-q2k2krnm	1106	7	of	of	IN
cord-022353-q2k2krnm	1106	8	ovarian	ovarian	JJ
cord-022353-q2k2krnm	1106	9	follicles	follicle	NNS
cord-022353-q2k2krnm	1106	10	in	in	IN
cord-022353-q2k2krnm	1106	11	the	the	DT
cord-022353-q2k2krnm	1106	12	female	female	NN
cord-022353-q2k2krnm	1106	13	and	and	CC
cord-022353-q2k2krnm	1106	14	promotes	promote	VBZ
cord-022353-q2k2krnm	1106	15	the	the	DT
cord-022353-q2k2krnm	1106	16	latter	latter	JJ
cord-022353-q2k2krnm	1106	17	stages	stage	NNS
cord-022353-q2k2krnm	1106	18	of	of	IN
cord-022353-q2k2krnm	1106	19	spermatogenesis	spermatogenesis	NN
cord-022353-q2k2krnm	1106	20	in	in	IN
cord-022353-q2k2krnm	1106	21	males	male	NNS
cord-022353-q2k2krnm	1106	22	.	.	.
cord-022353-q2k2krnm	1107	1	It	-PRON-	PRP
cord-022353-q2k2krnm	1107	2	acts	act	VBZ
cord-022353-q2k2krnm	1107	3	principally	principally	RB
cord-022353-q2k2krnm	1107	4	on	on	IN
cord-022353-q2k2krnm	1107	5	the	the	DT
cord-022353-q2k2krnm	1107	6	Sertoli	sertoli	JJ
cord-022353-q2k2krnm	1107	7	cells	cell	NNS
cord-022353-q2k2krnm	1107	8	of	of	IN
cord-022353-q2k2krnm	1107	9	the	the	DT
cord-022353-q2k2krnm	1107	10	seminiferous	seminiferous	JJ
cord-022353-q2k2krnm	1107	11	tubules	tubule	NNS
cord-022353-q2k2krnm	1107	12	of	of	IN
cord-022353-q2k2krnm	1107	13	the	the	DT
cord-022353-q2k2krnm	1107	14	testis	testis	NN
cord-022353-q2k2krnm	1107	15	and	and	CC
cord-022353-q2k2krnm	1107	16	induces	induce	VBZ
cord-022353-q2k2krnm	1107	17	the	the	DT
cord-022353-q2k2krnm	1107	18	secretion	secretion	NN
cord-022353-q2k2krnm	1107	19	of	of	IN
cord-022353-q2k2krnm	1107	20	androgen	androgen	NN
cord-022353-q2k2krnm	1107	21	-	-	HYPH
cord-022353-q2k2krnm	1107	22	binding	bind	VBG
cord-022353-q2k2krnm	1107	23	protein	protein	NN
cord-022353-q2k2krnm	1107	24	and	and	CC
cord-022353-q2k2krnm	1107	25	inhibin	inhibin	NN
cord-022353-q2k2krnm	1107	26	.	.	.
cord-022353-q2k2krnm	1108	1	In	in	IN
cord-022353-q2k2krnm	1108	2	females	female	NNS
cord-022353-q2k2krnm	1108	3	,	,	,
cord-022353-q2k2krnm	1108	4	FSH	FSH	NNP
cord-022353-q2k2krnm	1108	5	and	and	CC
cord-022353-q2k2krnm	1108	6	LH	LH	NNP
cord-022353-q2k2krnm	1108	7	have	have	VBP
cord-022353-q2k2krnm	1108	8	distinct	distinct	JJ
cord-022353-q2k2krnm	1108	9	secretory	secretory	JJ
cord-022353-q2k2krnm	1108	10	patterns	pattern	NNS
cord-022353-q2k2krnm	1108	11	that	that	WDT
cord-022353-q2k2krnm	1108	12	are	be	VBP
cord-022353-q2k2krnm	1108	13	synchronized	synchronize	VBN
cord-022353-q2k2krnm	1108	14	to	to	IN
cord-022353-q2k2krnm	1108	15	the	the	DT
cord-022353-q2k2krnm	1108	16	estrous	estrous	JJ
cord-022353-q2k2krnm	1108	17	cycle	cycle	NN
cord-022353-q2k2krnm	1108	18	;	;	:
cord-022353-q2k2krnm	1108	19	mouse	mouse	NN
cord-022353-q2k2krnm	1108	20	estrous	estrous	JJ
cord-022353-q2k2krnm	1108	21	cycles	cycle	NNS
cord-022353-q2k2krnm	1108	22	have	have	VBP
cord-022353-q2k2krnm	1108	23	a	a	DT
cord-022353-q2k2krnm	1108	24	4-to	4-to	CD
cord-022353-q2k2krnm	1108	25	5-day	5-day	JJ
cord-022353-q2k2krnm	1108	26	periodicity	periodicity	NN
cord-022353-q2k2krnm	1108	27	.	.	.
cord-022353-q2k2krnm	1109	1	In	in	IN
cord-022353-q2k2krnm	1109	2	addition	addition	NN
cord-022353-q2k2krnm	1109	3	to	to	IN
cord-022353-q2k2krnm	1109	4	estrous	estrous	JJ
cord-022353-q2k2krnm	1109	5	cycle	cycle	NN
cord-022353-q2k2krnm	1109	6	dependent	dependent	JJ
cord-022353-q2k2krnm	1109	7	rhythms	rhythm	NNS
cord-022353-q2k2krnm	1109	8	,	,	,
cord-022353-q2k2krnm	1109	9	both	both	CC
cord-022353-q2k2krnm	1109	10	LH	LH	NNP
cord-022353-q2k2krnm	1109	11	and	and	CC
cord-022353-q2k2krnm	1109	12	FSH	FSH	NNP
cord-022353-q2k2krnm	1109	13	have	have	VBP
cord-022353-q2k2krnm	1109	14	ultradian	ultradian	JJ
cord-022353-q2k2krnm	1109	15	pulses	pulse	NNS
cord-022353-q2k2krnm	1109	16	and	and	CC
cord-022353-q2k2krnm	1109	17	show	show	VB
cord-022353-q2k2krnm	1109	18	circadian	circadian	NN
cord-022353-q2k2krnm	1109	19	periodicity	periodicity	NN
cord-022353-q2k2krnm	1109	20	,	,	,
cord-022353-q2k2krnm	1109	21	with	with	IN
cord-022353-q2k2krnm	1109	22	highest	high	JJS
cord-022353-q2k2krnm	1109	23	levels	level	NNS
cord-022353-q2k2krnm	1109	24	occurring	occur	VBG
cord-022353-q2k2krnm	1109	25	during	during	IN
cord-022353-q2k2krnm	1109	26	the	the	DT
cord-022353-q2k2krnm	1109	27	dark	dark	JJ
cord-022353-q2k2krnm	1109	28	period	period	NN
cord-022353-q2k2krnm	1109	29	of	of	IN
cord-022353-q2k2krnm	1109	30	the	the	DT
cord-022353-q2k2krnm	1109	31	light	light	JJ
cord-022353-q2k2krnm	1109	32	cycle	cycle	NN
cord-022353-q2k2krnm	1109	33	.	.	.
cord-022353-q2k2krnm	1110	1	Testosterone	testosterone	NN
cord-022353-q2k2krnm	1110	2	,	,	,
cord-022353-q2k2krnm	1110	3	estrogen	estrogen	NN
cord-022353-q2k2krnm	1110	4	,	,	,
cord-022353-q2k2krnm	1110	5	and	and	CC
cord-022353-q2k2krnm	1110	6	progesterone	progesterone	NN
cord-022353-q2k2krnm	1110	7	all	all	DT
cord-022353-q2k2krnm	1110	8	provide	provide	VBP
cord-022353-q2k2krnm	1110	9	feedback	feedback	NN
cord-022353-q2k2krnm	1110	10	regulation	regulation	NN
cord-022353-q2k2krnm	1110	11	of	of	IN
cord-022353-q2k2krnm	1110	12	LH	LH	NNP
cord-022353-q2k2krnm	1110	13	and	and	CC
cord-022353-q2k2krnm	1110	14	FSH	fsh	NN
cord-022353-q2k2krnm	1110	15	secretion	secretion	NN
cord-022353-q2k2krnm	1110	16	(	(	-LRB-
cord-022353-q2k2krnm	1110	17	Woodman	Woodman	NNP
cord-022353-q2k2krnm	1110	18	1997	1997	CD
cord-022353-q2k2krnm	1110	19	)	)	-RRB-
cord-022353-q2k2krnm	1110	20	.	.	.
cord-022353-q2k2krnm	1111	1	Because	because	IN
cord-022353-q2k2krnm	1111	2	rat	rat	NN
cord-022353-q2k2krnm	1111	3	and	and	CC
cord-022353-q2k2krnm	1111	4	mice	mouse	NNS
cord-022353-q2k2krnm	1111	5	share	share	VBP
cord-022353-q2k2krnm	1111	6	considerable	considerable	JJ
cord-022353-q2k2krnm	1111	7	sequence	sequence	NN
cord-022353-q2k2krnm	1111	8	homology	homology	NN
cord-022353-q2k2krnm	1111	9	for	for	IN
cord-022353-q2k2krnm	1111	10	the	the	DT
cord-022353-q2k2krnm	1111	11	FSH-~	FSH-~	NNP
cord-022353-q2k2krnm	1111	12	chain	chain	NN
cord-022353-q2k2krnm	1111	13	,	,	,
cord-022353-q2k2krnm	1111	14	the	the	DT
cord-022353-q2k2krnm	1111	15	rat	rat	NN
cord-022353-q2k2krnm	1111	16	RIA	RIA	NNP
cord-022353-q2k2krnm	1111	17	kit	kit	NN
cord-022353-q2k2krnm	1111	18	from	from	IN
cord-022353-q2k2krnm	1111	19	National	National	NNP
cord-022353-q2k2krnm	1111	20	Institute	Institute	NNP
cord-022353-q2k2krnm	1111	21	of	of	IN
cord-022353-q2k2krnm	1111	22	Diabetes	Diabetes	NNP
cord-022353-q2k2krnm	1111	23	and	and	CC
cord-022353-q2k2krnm	1111	24	Digestive	digestive	JJ
cord-022353-q2k2krnm	1111	25	and	and	CC
cord-022353-q2k2krnm	1111	26	Kidney	kidney	NN
cord-022353-q2k2krnm	1111	27	Diseases	disease	NNS
cord-022353-q2k2krnm	1111	28	(	(	-LRB-
cord-022353-q2k2krnm	1111	29	NIDDK	NIDDK	NNP
cord-022353-q2k2krnm	1111	30	)	)	-RRB-
cord-022353-q2k2krnm	1111	31	can	can	MD
cord-022353-q2k2krnm	1111	32	be	be	VB
cord-022353-q2k2krnm	1111	33	used	use	VBN
cord-022353-q2k2krnm	1111	34	to	to	TO
cord-022353-q2k2krnm	1111	35	measure	measure	VB
cord-022353-q2k2krnm	1111	36	FSH	fsh	NN
cord-022353-q2k2krnm	1111	37	in	in	IN
cord-022353-q2k2krnm	1111	38	the	the	DT
cord-022353-q2k2krnm	1111	39	mouse	mouse	NN
cord-022353-q2k2krnm	1111	40	(	(	-LRB-
cord-022353-q2k2krnm	1111	41	Dalterio	Dalterio	NNP
cord-022353-q2k2krnm	1111	42	et	et	FW
cord-022353-q2k2krnm	1111	43	al	al	NNP
cord-022353-q2k2krnm	1111	44	.	.	NNP
cord-022353-q2k2krnm	1111	45	1981	1981	CD
cord-022353-q2k2krnm	1111	46	)	)	-RRB-
cord-022353-q2k2krnm	1111	47	.	.	.
cord-022353-q2k2krnm	1112	1	A	a	DT
cord-022353-q2k2krnm	1112	2	mouse	mouse	NN
cord-022353-q2k2krnm	1112	3	specific	specific	JJ
cord-022353-q2k2krnm	1112	4	RIA	RIA	NNP
cord-022353-q2k2krnm	1112	5	is	be	VBZ
cord-022353-q2k2krnm	1112	6	commercially	commercially	RB
cord-022353-q2k2krnm	1112	7	available	available	JJ
cord-022353-q2k2krnm	1112	8	.	.	.
cord-022353-q2k2krnm	1113	1	In	in	IN
cord-022353-q2k2krnm	1113	2	cycling	cycling	NN
cord-022353-q2k2krnm	1113	3	female	female	JJ
cord-022353-q2k2krnm	1113	4	mice	mouse	NNS
cord-022353-q2k2krnm	1113	5	,	,	,
cord-022353-q2k2krnm	1113	6	the	the	DT
cord-022353-q2k2krnm	1113	7	plasma	plasma	NN
cord-022353-q2k2krnm	1113	8	levels	level	NNS
cord-022353-q2k2krnm	1113	9	of	of	IN
cord-022353-q2k2krnm	1113	10	FSH	fsh	NN
cord-022353-q2k2krnm	1113	11	increase	increase	NN
cord-022353-q2k2krnm	1113	12	from	from	IN
cord-022353-q2k2krnm	1113	13	80	80	CD
cord-022353-q2k2krnm	1113	14	to	to	TO
cord-022353-q2k2krnm	1113	15	120	120	CD
cord-022353-q2k2krnm	1113	16	ng	ng	NN
cord-022353-q2k2krnm	1113	17	/	/	SYM
cord-022353-q2k2krnm	1113	18	ml	ml	NN
cord-022353-q2k2krnm	1113	19	during	during	IN
cord-022353-q2k2krnm	1113	20	proestrus	proestrus	NNP
cord-022353-q2k2krnm	1113	21	and	and	CC
cord-022353-q2k2krnm	1113	22	250	250	CD
cord-022353-q2k2krnm	1113	23	-	-	SYM
cord-022353-q2k2krnm	1113	24	300	300	CD
cord-022353-q2k2krnm	1113	25	ng	ng	NN
cord-022353-q2k2krnm	1113	26	/	/	SYM
cord-022353-q2k2krnm	1113	27	ml	ml	NN
cord-022353-q2k2krnm	1113	28	during	during	IN
cord-022353-q2k2krnm	1113	29	estrus	estrus	NN
cord-022353-q2k2krnm	1113	30	.	.	.
cord-022353-q2k2krnm	1114	1	Although	although	IN
cord-022353-q2k2krnm	1114	2	Bronson	Bronson	NNP
cord-022353-q2k2krnm	1114	3	and	and	CC
cord-022353-q2k2krnm	1114	4	Desjardins	Desjardins	NNP
cord-022353-q2k2krnm	1114	5	(	(	-LRB-
cord-022353-q2k2krnm	1114	6	1977	1977	CD
cord-022353-q2k2krnm	1114	7	)	)	-RRB-
cord-022353-q2k2krnm	1114	8	found	find	VBD
cord-022353-q2k2krnm	1114	9	age	age	NN
cord-022353-q2k2krnm	1114	10	associated	associate	VBN
cord-022353-q2k2krnm	1114	11	decreases	decrease	VBZ
cord-022353-q2k2krnm	1114	12	in	in	IN
cord-022353-q2k2krnm	1114	13	serum	serum	NN
cord-022353-q2k2krnm	1114	14	LH	lh	NN
cord-022353-q2k2krnm	1114	15	and	and	CC
cord-022353-q2k2krnm	1114	16	testosterone	testosterone	NN
cord-022353-q2k2krnm	1114	17	in	in	IN
cord-022353-q2k2krnm	1114	18	male	male	JJ
cord-022353-q2k2krnm	1114	19	CBF	CBF	NNP
cord-022353-q2k2krnm	1114	20	1	1	CD
cord-022353-q2k2krnm	1114	21	mice	mouse	NNS
cord-022353-q2k2krnm	1114	22	experiencing	experience	VBG
cord-022353-q2k2krnm	1114	23	decreased	decrease	VBN
cord-022353-q2k2krnm	1114	24	sperm	sperm	NN
cord-022353-q2k2krnm	1114	25	production	production	NN
cord-022353-q2k2krnm	1114	26	,	,	,
cord-022353-q2k2krnm	1114	27	no	no	DT
cord-022353-q2k2krnm	1114	28	similar	similar	JJ
cord-022353-q2k2krnm	1114	29	decreases	decrease	NNS
cord-022353-q2k2krnm	1114	30	were	be	VBD
cord-022353-q2k2krnm	1114	31	observed	observe	VBN
cord-022353-q2k2krnm	1114	32	in	in	IN
cord-022353-q2k2krnm	1114	33	FSH	fsh	NN
cord-022353-q2k2krnm	1114	34	concentration	concentration	NN
cord-022353-q2k2krnm	1114	35	.	.	.
cord-022353-q2k2krnm	1115	1	No	no	DT
cord-022353-q2k2krnm	1115	2	significant	significant	JJ
cord-022353-q2k2krnm	1115	3	differences	difference	NNS
cord-022353-q2k2krnm	1115	4	in	in	IN
cord-022353-q2k2krnm	1115	5	the	the	DT
cord-022353-q2k2krnm	1115	6	twofold	twofold	JJ
cord-022353-q2k2krnm	1115	7	increased	increase	VBN
cord-022353-q2k2krnm	1115	8	FSH	fsh	NN
cord-022353-q2k2krnm	1115	9	levels	level	NNS
cord-022353-q2k2krnm	1115	10	were	be	VBD
cord-022353-q2k2krnm	1115	11	seen	see	VBN
cord-022353-q2k2krnm	1115	12	among	among	IN
cord-022353-q2k2krnm	1115	13	young	young	JJ
cord-022353-q2k2krnm	1115	14	versus	versus	IN
cord-022353-q2k2krnm	1115	15	old	old	JJ
cord-022353-q2k2krnm	1115	16	males	male	NNS
cord-022353-q2k2krnm	1115	17	following	follow	VBG
cord-022353-q2k2krnm	1115	18	castration	castration	NN
cord-022353-q2k2krnm	1115	19	.	.	.
cord-022353-q2k2krnm	1116	1	This	this	DT
cord-022353-q2k2krnm	1116	2	appears	appear	VBZ
cord-022353-q2k2krnm	1116	3	to	to	TO
cord-022353-q2k2krnm	1116	4	differ	differ	VB
cord-022353-q2k2krnm	1116	5	from	from	IN
cord-022353-q2k2krnm	1116	6	results	result	NNS
cord-022353-q2k2krnm	1116	7	obtained	obtain	VBN
cord-022353-q2k2krnm	1116	8	from	from	IN
cord-022353-q2k2krnm	1116	9	young	young	JJ
cord-022353-q2k2krnm	1116	10	versus	versus	IN
cord-022353-q2k2krnm	1116	11	old	old	JJ
cord-022353-q2k2krnm	1116	12	rats	rat	NNS
cord-022353-q2k2krnm	1116	13	(	(	-LRB-
cord-022353-q2k2krnm	1116	14	Finch	Finch	NNP
cord-022353-q2k2krnm	1116	15	et	et	FW
cord-022353-q2k2krnm	1116	16	al	al	NNP
cord-022353-q2k2krnm	1116	17	.	.	NNP
cord-022353-q2k2krnm	1116	18	1977	1977	CD
cord-022353-q2k2krnm	1116	19	)	)	-RRB-
cord-022353-q2k2krnm	1116	20	.	.	.
cord-022353-q2k2krnm	1117	1	The	the	DT
cord-022353-q2k2krnm	1117	2	regulation	regulation	NN
cord-022353-q2k2krnm	1117	3	and	and	CC
cord-022353-q2k2krnm	1117	4	function	function	NN
cord-022353-q2k2krnm	1117	5	of	of	IN
cord-022353-q2k2krnm	1117	6	FSH	FSH	NNP
cord-022353-q2k2krnm	1117	7	has	have	VBZ
cord-022353-q2k2krnm	1117	8	been	be	VBN
cord-022353-q2k2krnm	1117	9	studied	study	VBN
cord-022353-q2k2krnm	1117	10	in	in	IN
cord-022353-q2k2krnm	1117	11	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1117	12	and	and	CC
cord-022353-q2k2krnm	1117	13	KO	KO	NNP
cord-022353-q2k2krnm	1117	14	mice	mouse	NNS
cord-022353-q2k2krnm	1117	15	(	(	-LRB-
cord-022353-q2k2krnm	1117	16	Cooke	Cooke	NNP
cord-022353-q2k2krnm	1117	17	and	and	CC
cord-022353-q2k2krnm	1117	18	Saunders	Saunders	NNP
cord-022353-q2k2krnm	1117	19	2002	2002	CD
cord-022353-q2k2krnm	1117	20	;	;	:
cord-022353-q2k2krnm	1117	21	Wells	Wells	NNP
cord-022353-q2k2krnm	1117	22	and	and	CC
cord-022353-q2k2krnm	1117	23	Murphy	Murphy	NNP
cord-022353-q2k2krnm	1117	24	2003	2003	CD
cord-022353-q2k2krnm	1117	25	)	)	-RRB-
cord-022353-q2k2krnm	1117	26	.	.	.
cord-022353-q2k2krnm	1118	1	Testosterone	testosterone	NN
cord-022353-q2k2krnm	1118	2	promotes	promote	VBZ
cord-022353-q2k2krnm	1118	3	spermatogenesis	spermatogenesis	NN
cord-022353-q2k2krnm	1118	4	and	and	CC
cord-022353-q2k2krnm	1118	5	provides	provide	VBZ
cord-022353-q2k2krnm	1118	6	feedback	feedback	NN
cord-022353-q2k2krnm	1118	7	regulation	regulation	NN
cord-022353-q2k2krnm	1118	8	of	of	IN
cord-022353-q2k2krnm	1118	9	gonadotrophin	gonadotrophin	NN
cord-022353-q2k2krnm	1118	10	synthesis	synthesis	NN
cord-022353-q2k2krnm	1118	11	.	.	.
cord-022353-q2k2krnm	1119	1	Through	through	IN
cord-022353-q2k2krnm	1119	2	its	-PRON-	PRP$
cord-022353-q2k2krnm	1119	3	action	action	NN
cord-022353-q2k2krnm	1119	4	on	on	IN
cord-022353-q2k2krnm	1119	5	the	the	DT
cord-022353-q2k2krnm	1119	6	epididymis	epididymis	NN
cord-022353-q2k2krnm	1119	7	,	,	,
cord-022353-q2k2krnm	1119	8	proteins	protein	NNS
cord-022353-q2k2krnm	1119	9	necessary	necessary	JJ
cord-022353-q2k2krnm	1119	10	for	for	IN
cord-022353-q2k2krnm	1119	11	spermatozoal	spermatozoal	NNP
cord-022353-q2k2krnm	1119	12	maturation	maturation	NN
cord-022353-q2k2krnm	1119	13	are	be	VBP
cord-022353-q2k2krnm	1119	14	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1119	15	.	.	.
cord-022353-q2k2krnm	1120	1	Dihydrotestosterone	Dihydrotestosterone	NNP
cord-022353-q2k2krnm	1120	2	(	(	-LRB-
cord-022353-q2k2krnm	1120	3	DHT	DHT	NNP
cord-022353-q2k2krnm	1120	4	)	)	-RRB-
cord-022353-q2k2krnm	1120	5	promotes	promote	VBZ
cord-022353-q2k2krnm	1120	6	the	the	DT
cord-022353-q2k2krnm	1120	7	growth	growth	NN
cord-022353-q2k2krnm	1120	8	and	and	CC
cord-022353-q2k2krnm	1120	9	differentiation	differentiation	NN
cord-022353-q2k2krnm	1120	10	of	of	IN
cord-022353-q2k2krnm	1120	11	accessory	accessory	JJ
cord-022353-q2k2krnm	1120	12	sex	sex	NN
cord-022353-q2k2krnm	1120	13	organs	organ	NNS
cord-022353-q2k2krnm	1120	14	(	(	-LRB-
cord-022353-q2k2krnm	1120	15	DePaolo	DePaolo	NNP
cord-022353-q2k2krnm	1120	16	and	and	CC
cord-022353-q2k2krnm	1120	17	Masoro	Masoro	NNP
cord-022353-q2k2krnm	1120	18	1989	1989	CD
cord-022353-q2k2krnm	1120	19	)	)	-RRB-
cord-022353-q2k2krnm	1120	20	.	.	.
cord-022353-q2k2krnm	1121	1	In	in	IN
cord-022353-q2k2krnm	1121	2	addition	addition	NN
cord-022353-q2k2krnm	1121	3	to	to	IN
cord-022353-q2k2krnm	1121	4	their	-PRON-	PRP$
cord-022353-q2k2krnm	1121	5	effects	effect	NNS
cord-022353-q2k2krnm	1121	6	on	on	IN
cord-022353-q2k2krnm	1121	7	reproductive	reproductive	JJ
cord-022353-q2k2krnm	1121	8	organs	organ	NNS
cord-022353-q2k2krnm	1121	9	,	,	,
cord-022353-q2k2krnm	1121	10	testosterone	testosterone	NN
cord-022353-q2k2krnm	1121	11	and	and	CC
cord-022353-q2k2krnm	1121	12	DHT	DHT	NNP
cord-022353-q2k2krnm	1121	13	have	have	VBP
cord-022353-q2k2krnm	1121	14	physiologic	physiologic	JJ
cord-022353-q2k2krnm	1121	15	functions	function	NNS
cord-022353-q2k2krnm	1121	16	on	on	IN
cord-022353-q2k2krnm	1121	17	the	the	DT
cord-022353-q2k2krnm	1121	18	central	central	JJ
cord-022353-q2k2krnm	1121	19	nervous	nervous	JJ
cord-022353-q2k2krnm	1121	20	system	system	NN
cord-022353-q2k2krnm	1121	21	,	,	,
cord-022353-q2k2krnm	1121	22	cardiac	cardiac	JJ
cord-022353-q2k2krnm	1121	23	tissue	tissue	NN
cord-022353-q2k2krnm	1121	24	,	,	,
cord-022353-q2k2krnm	1121	25	and	and	CC
cord-022353-q2k2krnm	1121	26	the	the	DT
cord-022353-q2k2krnm	1121	27	liver	liver	NN
cord-022353-q2k2krnm	1121	28	.	.	.
cord-022353-q2k2krnm	1122	1	In	in	IN
cord-022353-q2k2krnm	1122	2	the	the	DT
cord-022353-q2k2krnm	1122	3	mouse	mouse	NN
cord-022353-q2k2krnm	1122	4	,	,	,
cord-022353-q2k2krnm	1122	5	testosterone	testosterone	NN
cord-022353-q2k2krnm	1122	6	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	1122	7	the	the	DT
cord-022353-q2k2krnm	1122	8	growth	growth	NN
cord-022353-q2k2krnm	1122	9	of	of	IN
cord-022353-q2k2krnm	1122	10	kidneys	kidney	NNS
cord-022353-q2k2krnm	1122	11	and	and	CC
cord-022353-q2k2krnm	1122	12	synthesis	synthesis	NN
cord-022353-q2k2krnm	1122	13	of	of	IN
cord-022353-q2k2krnm	1122	14	erythropoietin	erythropoietin	NN
cord-022353-q2k2krnm	1122	15	(	(	-LRB-
cord-022353-q2k2krnm	1122	16	Woodman	Woodman	NNP
cord-022353-q2k2krnm	1122	17	1997	1997	CD
cord-022353-q2k2krnm	1122	18	)	)	-RRB-
cord-022353-q2k2krnm	1122	19	.	.	.
cord-022353-q2k2krnm	1123	1	LH	LH	NNP
cord-022353-q2k2krnm	1123	2	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	1123	3	synthesis	synthesis	NN
cord-022353-q2k2krnm	1123	4	of	of	IN
cord-022353-q2k2krnm	1123	5	testosterone	testosterone	NN
cord-022353-q2k2krnm	1123	6	from	from	IN
cord-022353-q2k2krnm	1123	7	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1123	8	by	by	IN
cord-022353-q2k2krnm	1123	9	the	the	DT
cord-022353-q2k2krnm	1123	10	interstitial	interstitial	JJ
cord-022353-q2k2krnm	1123	11	Leydig	Leydig	NNP
cord-022353-q2k2krnm	1123	12	cells	cell	NNS
cord-022353-q2k2krnm	1123	13	of	of	IN
cord-022353-q2k2krnm	1123	14	the	the	DT
cord-022353-q2k2krnm	1123	15	testis	testis	NN
cord-022353-q2k2krnm	1123	16	.	.	.
cord-022353-q2k2krnm	1124	1	In	in	IN
cord-022353-q2k2krnm	1124	2	target	target	NN
cord-022353-q2k2krnm	1124	3	tissues	tissue	NNS
cord-022353-q2k2krnm	1124	4	,	,	,
cord-022353-q2k2krnm	1124	5	the	the	DT
cord-022353-q2k2krnm	1124	6	enzyme	enzyme	NN
cord-022353-q2k2krnm	1124	7	5r	5r	CD
cord-022353-q2k2krnm	1124	8	converts	convert	VBZ
cord-022353-q2k2krnm	1124	9	testosterone	testosterone	NN
cord-022353-q2k2krnm	1124	10	to	to	IN
cord-022353-q2k2krnm	1124	11	DHT	DHT	NNP
cord-022353-q2k2krnm	1124	12	.	.	.
cord-022353-q2k2krnm	1125	1	In	in	IN
cord-022353-q2k2krnm	1125	2	the	the	DT
cord-022353-q2k2krnm	1125	3	fetal	fetal	JJ
cord-022353-q2k2krnm	1125	4	testes	testis	NNS
cord-022353-q2k2krnm	1125	5	,	,	,
cord-022353-q2k2krnm	1125	6	Leydig	leydig	NN
cord-022353-q2k2krnm	1125	7	cells	cell	NNS
cord-022353-q2k2krnm	1125	8	first	first	RB
cord-022353-q2k2krnm	1125	9	become	become	VBP
cord-022353-q2k2krnm	1125	10	identifiable	identifiable	JJ
cord-022353-q2k2krnm	1125	11	during	during	IN
cord-022353-q2k2krnm	1125	12	the	the	DT
cord-022353-q2k2krnm	1125	13	rise	rise	NN
cord-022353-q2k2krnm	1125	14	of	of	IN
cord-022353-q2k2krnm	1125	15	testosterone	testosterone	NN
cord-022353-q2k2krnm	1125	16	.	.	.
cord-022353-q2k2krnm	1126	1	In	in	IN
cord-022353-q2k2krnm	1126	2	most	most	JJS
cord-022353-q2k2krnm	1126	3	mammalian	mammalian	JJ
cord-022353-q2k2krnm	1126	4	species	specie	NNS
cord-022353-q2k2krnm	1126	5	,	,	,
cord-022353-q2k2krnm	1126	6	Leydig	leydig	NN
cord-022353-q2k2krnm	1126	7	cells	cell	NNS
cord-022353-q2k2krnm	1126	8	disappear	disappear	VBP
cord-022353-q2k2krnm	1126	9	when	when	WRB
cord-022353-q2k2krnm	1126	10	testosterone	testosterone	NN
cord-022353-q2k2krnm	1126	11	levels	level	NNS
cord-022353-q2k2krnm	1126	12	fall	fall	VBP
cord-022353-q2k2krnm	1126	13	during	during	IN
cord-022353-q2k2krnm	1126	14	gestation	gestation	NN
cord-022353-q2k2krnm	1126	15	.	.	.
cord-022353-q2k2krnm	1127	1	However	however	RB
cord-022353-q2k2krnm	1127	2	,	,	,
cord-022353-q2k2krnm	1127	3	the	the	DT
cord-022353-q2k2krnm	1127	4	mouse	mouse	NN
cord-022353-q2k2krnm	1127	5	is	be	VBZ
cord-022353-q2k2krnm	1127	6	an	an	DT
cord-022353-q2k2krnm	1127	7	exception	exception	NN
cord-022353-q2k2krnm	1127	8	and	and	CC
cord-022353-q2k2krnm	1127	9	Leydig	leydig	NN
cord-022353-q2k2krnm	1127	10	cells	cell	NNS
cord-022353-q2k2krnm	1127	11	do	do	VBP
cord-022353-q2k2krnm	1127	12	not	not	RB
cord-022353-q2k2krnm	1127	13	undergo	undergo	VB
cord-022353-q2k2krnm	1127	14	regression	regression	NN
cord-022353-q2k2krnm	1127	15	postnatally	postnatally	NN
cord-022353-q2k2krnm	1127	16	(	(	-LRB-
cord-022353-q2k2krnm	1127	17	Aoki	Aoki	NNP
cord-022353-q2k2krnm	1127	18	1970	1970	CD
cord-022353-q2k2krnm	1127	19	)	)	-RRB-
cord-022353-q2k2krnm	1127	20	.	.	.
cord-022353-q2k2krnm	1128	1	Testosterone	testosterone	NN
cord-022353-q2k2krnm	1128	2	and	and	CC
cord-022353-q2k2krnm	1128	3	DHT	DHT	NNP
cord-022353-q2k2krnm	1128	4	circulate	circulate	VBP
cord-022353-q2k2krnm	1128	5	in	in	IN
cord-022353-q2k2krnm	1128	6	both	both	CC
cord-022353-q2k2krnm	1128	7	free	free	JJ
cord-022353-q2k2krnm	1128	8	and	and	CC
cord-022353-q2k2krnm	1128	9	protein	protein	NN
cord-022353-q2k2krnm	1128	10	bound	bind	VBN
cord-022353-q2k2krnm	1128	11	forms	form	NNS
cord-022353-q2k2krnm	1128	12	.	.	.
cord-022353-q2k2krnm	1129	1	Ninety	ninety	CD
cord-022353-q2k2krnm	1129	2	-	-	HYPH
cord-022353-q2k2krnm	1129	3	eight	eight	CD
cord-022353-q2k2krnm	1129	4	percent	percent	NN
cord-022353-q2k2krnm	1129	5	of	of	IN
cord-022353-q2k2krnm	1129	6	total	total	JJ
cord-022353-q2k2krnm	1129	7	testosterone	testosterone	NN
cord-022353-q2k2krnm	1129	8	is	be	VBZ
cord-022353-q2k2krnm	1129	9	bound	bind	VBN
cord-022353-q2k2krnm	1129	10	to	to	IN
cord-022353-q2k2krnm	1129	11	protein	protein	NN
cord-022353-q2k2krnm	1129	12	,	,	,
cord-022353-q2k2krnm	1129	13	mainly	mainly	RB
cord-022353-q2k2krnm	1129	14	albumin	albumin	NN
cord-022353-q2k2krnm	1129	15	.	.	.
cord-022353-q2k2krnm	1130	1	Mice	mouse	NNS
cord-022353-q2k2krnm	1130	2	,	,	,
cord-022353-q2k2krnm	1130	3	unlike	unlike	IN
cord-022353-q2k2krnm	1130	4	humans	human	NNS
cord-022353-q2k2krnm	1130	5	,	,	,
cord-022353-q2k2krnm	1130	6	dogs	dog	NNS
cord-022353-q2k2krnm	1130	7	,	,	,
cord-022353-q2k2krnm	1130	8	monkeys	monkey	NNS
cord-022353-q2k2krnm	1130	9	,	,	,
cord-022353-q2k2krnm	1130	10	and	and	CC
cord-022353-q2k2krnm	1130	11	cats	cat	NNS
cord-022353-q2k2krnm	1130	12	,	,	,
cord-022353-q2k2krnm	1130	13	do	do	VBP
cord-022353-q2k2krnm	1130	14	not	not	RB
cord-022353-q2k2krnm	1130	15	have	have	VB
cord-022353-q2k2krnm	1130	16	circulating	circulate	VBG
cord-022353-q2k2krnm	1130	17	sex	sex	NN
cord-022353-q2k2krnm	1130	18	hormone	hormone	NN
cord-022353-q2k2krnm	1130	19	-	-	HYPH
cord-022353-q2k2krnm	1130	20	binding	bind	VBG
cord-022353-q2k2krnm	1130	21	globulin	globulin	NN
cord-022353-q2k2krnm	1130	22	.	.	.
cord-022353-q2k2krnm	1131	1	In	in	IN
cord-022353-q2k2krnm	1131	2	mice	mouse	NNS
cord-022353-q2k2krnm	1131	3	,	,	,
cord-022353-q2k2krnm	1131	4	a	a	DT
cord-022353-q2k2krnm	1131	5	pulse	pulse	NN
cord-022353-q2k2krnm	1131	6	release	release	NN
cord-022353-q2k2krnm	1131	7	pattern	pattern	NN
cord-022353-q2k2krnm	1131	8	may	may	MD
cord-022353-q2k2krnm	1131	9	be	be	VB
cord-022353-q2k2krnm	1131	10	seen	see	VBN
cord-022353-q2k2krnm	1131	11	within	within	IN
cord-022353-q2k2krnm	1131	12	their	-PRON-	PRP$
cord-022353-q2k2krnm	1131	13	diurnal	diurnal	JJ
cord-022353-q2k2krnm	1131	14	rhythm	rhythm	NN
cord-022353-q2k2krnm	1131	15	of	of	IN
cord-022353-q2k2krnm	1131	16	testosterone	testosterone	NN
cord-022353-q2k2krnm	1131	17	.	.	.
cord-022353-q2k2krnm	1132	1	Testosterone	testosterone	NN
cord-022353-q2k2krnm	1132	2	can	can	MD
cord-022353-q2k2krnm	1132	3	be	be	VB
cord-022353-q2k2krnm	1132	4	measured	measure	VBN
cord-022353-q2k2krnm	1132	5	in	in	IN
cord-022353-q2k2krnm	1132	6	mice	mouse	NNS
cord-022353-q2k2krnm	1132	7	using	use	VBG
cord-022353-q2k2krnm	1132	8	RIA	RIA	NNP
cord-022353-q2k2krnm	1132	9	or	or	CC
cord-022353-q2k2krnm	1132	10	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1132	11	.	.	.
cord-022353-q2k2krnm	1133	1	Plasma	plasma	NN
cord-022353-q2k2krnm	1133	2	testosterone	testosterone	NN
cord-022353-q2k2krnm	1133	3	was	be	VBD
cord-022353-q2k2krnm	1133	4	not	not	RB
cord-022353-q2k2krnm	1133	5	found	find	VBN
cord-022353-q2k2krnm	1133	6	to	to	TO
cord-022353-q2k2krnm	1133	7	change	change	VB
cord-022353-q2k2krnm	1133	8	during	during	IN
cord-022353-q2k2krnm	1133	9	the	the	DT
cord-022353-q2k2krnm	1133	10	average	average	JJ
cord-022353-q2k2krnm	1133	11	lifespan	lifespan	NN
cord-022353-q2k2krnm	1133	12	of	of	IN
cord-022353-q2k2krnm	1133	13	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1133	14	and	and	CC
cord-022353-q2k2krnm	1133	15	DBA/2J	dba/2j	NN
cord-022353-q2k2krnm	1133	16	mice	mouse	NNS
cord-022353-q2k2krnm	1133	17	(	(	-LRB-
cord-022353-q2k2krnm	1133	18	Finch	Finch	NNP
cord-022353-q2k2krnm	1133	19	et	et	FW
cord-022353-q2k2krnm	1133	20	al	al	NNP
cord-022353-q2k2krnm	1133	21	.	.	NNP
cord-022353-q2k2krnm	1133	22	1977	1977	CD
cord-022353-q2k2krnm	1133	23	)	)	-RRB-
cord-022353-q2k2krnm	1133	24	.	.	.
cord-022353-q2k2krnm	1134	1	This	this	DT
cord-022353-q2k2krnm	1134	2	is	be	VBZ
cord-022353-q2k2krnm	1134	3	in	in	IN
cord-022353-q2k2krnm	1134	4	contrast	contrast	NN
cord-022353-q2k2krnm	1134	5	to	to	IN
cord-022353-q2k2krnm	1134	6	CBF1	CBF1	NNP
cord-022353-q2k2krnm	1134	7	mice	mouse	NNS
cord-022353-q2k2krnm	1134	8	,	,	,
cord-022353-q2k2krnm	1134	9	Wistar	Wistar	NNP
cord-022353-q2k2krnm	1134	10	and	and	CC
cord-022353-q2k2krnm	1134	11	Long	Long	NNP
cord-022353-q2k2krnm	1134	12	-	-	HYPH
cord-022353-q2k2krnm	1134	13	Evans	Evans	NNP
cord-022353-q2k2krnm	1134	14	rats	rat	NNS
cord-022353-q2k2krnm	1134	15	,	,	,
cord-022353-q2k2krnm	1134	16	and	and	CC
cord-022353-q2k2krnm	1134	17	humans	human	NNS
cord-022353-q2k2krnm	1134	18	,	,	,
cord-022353-q2k2krnm	1134	19	which	which	WDT
cord-022353-q2k2krnm	1134	20	experience	experience	VBP
cord-022353-q2k2krnm	1134	21	greater	great	JJR
cord-022353-q2k2krnm	1134	22	than	than	IN
cord-022353-q2k2krnm	1134	23	a	a	DT
cord-022353-q2k2krnm	1134	24	30	30	CD
cord-022353-q2k2krnm	1134	25	%	%	NN
cord-022353-q2k2krnm	1134	26	decrease	decrease	NN
cord-022353-q2k2krnm	1134	27	in	in	IN
cord-022353-q2k2krnm	1134	28	testosterone	testosterone	NN
cord-022353-q2k2krnm	1134	29	at	at	IN
cord-022353-q2k2krnm	1134	30	midlife	midlife	NN
cord-022353-q2k2krnm	1134	31	(	(	-LRB-
cord-022353-q2k2krnm	1134	32	Bronson	Bronson	NNP
cord-022353-q2k2krnm	1134	33	and	and	CC
cord-022353-q2k2krnm	1134	34	Desjardins	Desjardins	NNP
cord-022353-q2k2krnm	1134	35	1977	1977	CD
cord-022353-q2k2krnm	1134	36	)	)	-RRB-
cord-022353-q2k2krnm	1134	37	.	.	.
cord-022353-q2k2krnm	1135	1	In	in	IN
cord-022353-q2k2krnm	1135	2	contrast	contrast	NN
cord-022353-q2k2krnm	1135	3	to	to	IN
cord-022353-q2k2krnm	1135	4	testosterone	testosterone	NN
cord-022353-q2k2krnm	1135	5	levels	level	NNS
cord-022353-q2k2krnm	1135	6	in	in	IN
cord-022353-q2k2krnm	1135	7	older	old	JJR
cord-022353-q2k2krnm	1135	8	mice	mouse	NNS
cord-022353-q2k2krnm	1135	9	,	,	,
cord-022353-q2k2krnm	1135	10	castration	castration	NN
cord-022353-q2k2krnm	1135	11	-	-	HYPH
cord-022353-q2k2krnm	1135	12	induced	induce	VBN
cord-022353-q2k2krnm	1135	13	elevation	elevation	NN
cord-022353-q2k2krnm	1135	14	of	of	IN
cord-022353-q2k2krnm	1135	15	LH	LH	NNP
cord-022353-q2k2krnm	1135	16	was	be	VBD
cord-022353-q2k2krnm	1135	17	impaired	impair	VBN
cord-022353-q2k2krnm	1135	18	in	in	IN
cord-022353-q2k2krnm	1135	19	28-month	28-month	JJ
cord-022353-q2k2krnm	1135	20	-	-	HYPH
cord-022353-q2k2krnm	1135	21	old	old	JJ
cord-022353-q2k2krnm	1135	22	C57BL/6J	C57BL/6J	NNP
cord-022353-q2k2krnm	1135	23	mice	mouse	NNS
cord-022353-q2k2krnm	1135	24	compared	compare	VBN
cord-022353-q2k2krnm	1135	25	to	to	IN
cord-022353-q2k2krnm	1135	26	12-month	12-month	JJ
cord-022353-q2k2krnm	1135	27	-	-	HYPH
cord-022353-q2k2krnm	1135	28	old	old	JJ
cord-022353-q2k2krnm	1135	29	mice	mouse	NNS
cord-022353-q2k2krnm	1135	30	.	.	.
cord-022353-q2k2krnm	1136	1	Androgen	androgen	NN
cord-022353-q2k2krnm	1136	2	receptor	receptor	NN
cord-022353-q2k2krnm	1136	3	KO	KO	NNP
cord-022353-q2k2krnm	1136	4	mice	mouse	NNS
cord-022353-q2k2krnm	1136	5	have	have	VBP
cord-022353-q2k2krnm	1136	6	been	be	VBN
cord-022353-q2k2krnm	1136	7	described	describe	VBN
cord-022353-q2k2krnm	1136	8	(	(	-LRB-
cord-022353-q2k2krnm	1136	9	Cooke	Cooke	NNP
cord-022353-q2k2krnm	1136	10	and	and	CC
cord-022353-q2k2krnm	1136	11	Saunders	Saunders	NNP
cord-022353-q2k2krnm	1136	12	2002	2002	CD
cord-022353-q2k2krnm	1136	13	)	)	-RRB-
cord-022353-q2k2krnm	1136	14	.	.	.
cord-022353-q2k2krnm	1137	1	5	5	LS
cord-022353-q2k2krnm	1137	2	.	.	.
cord-022353-q2k2krnm	1138	1	Estradiol	Estradiol	NNP
cord-022353-q2k2krnm	1138	2	(	(	-LRB-
cord-022353-q2k2krnm	1138	3	E2	E2	NNP
cord-022353-q2k2krnm	1138	4	)	)	-RRB-
cord-022353-q2k2krnm	1139	1	The	the	DT
cord-022353-q2k2krnm	1139	2	granulosa	granulosa	JJ
cord-022353-q2k2krnm	1139	3	cells	cell	NNS
cord-022353-q2k2krnm	1139	4	of	of	IN
cord-022353-q2k2krnm	1139	5	the	the	DT
cord-022353-q2k2krnm	1139	6	mature	mature	JJ
cord-022353-q2k2krnm	1139	7	Graafian	graafian	JJ
cord-022353-q2k2krnm	1139	8	follicle	follicle	NN
cord-022353-q2k2krnm	1139	9	are	be	VBP
cord-022353-q2k2krnm	1139	10	the	the	DT
cord-022353-q2k2krnm	1139	11	main	main	JJ
cord-022353-q2k2krnm	1139	12	source	source	NN
cord-022353-q2k2krnm	1139	13	of	of	IN
cord-022353-q2k2krnm	1139	14	17[3-estradiol	17[3-estradiol	CD
cord-022353-q2k2krnm	1139	15	(	(	-LRB-
cord-022353-q2k2krnm	1139	16	E2	E2	NNP
cord-022353-q2k2krnm	1139	17	)	)	-RRB-
cord-022353-q2k2krnm	1139	18	in	in	IN
cord-022353-q2k2krnm	1139	19	mammals	mammal	NNS
cord-022353-q2k2krnm	1139	20	.	.	.
cord-022353-q2k2krnm	1140	1	FSH	FSH	NNP
cord-022353-q2k2krnm	1140	2	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	1140	3	the	the	DT
cord-022353-q2k2krnm	1140	4	activation	activation	NN
cord-022353-q2k2krnm	1140	5	of	of	IN
cord-022353-q2k2krnm	1140	6	aromatase	aromatase	NN
cord-022353-q2k2krnm	1140	7	in	in	IN
cord-022353-q2k2krnm	1140	8	follicles	follicle	NNS
cord-022353-q2k2krnm	1140	9	,	,	,
cord-022353-q2k2krnm	1140	10	which	which	WDT
cord-022353-q2k2krnm	1140	11	is	be	VBZ
cord-022353-q2k2krnm	1140	12	responsible	responsible	JJ
cord-022353-q2k2krnm	1140	13	for	for	IN
cord-022353-q2k2krnm	1140	14	the	the	DT
cord-022353-q2k2krnm	1140	15	conversion	conversion	NN
cord-022353-q2k2krnm	1140	16	of	of	IN
cord-022353-q2k2krnm	1140	17	androgens	androgen	NNS
cord-022353-q2k2krnm	1140	18	to	to	IN
cord-022353-q2k2krnm	1140	19	E2	E2	NNP
cord-022353-q2k2krnm	1140	20	.	.	.
cord-022353-q2k2krnm	1141	1	E	e	LS
cord-022353-q2k2krnm	1141	2	2	2	CD
cord-022353-q2k2krnm	1141	3	is	be	VBZ
cord-022353-q2k2krnm	1141	4	also	also	RB
cord-022353-q2k2krnm	1141	5	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1141	6	by	by	IN
cord-022353-q2k2krnm	1141	7	the	the	DT
cord-022353-q2k2krnm	1141	8	testis	testis	NN
cord-022353-q2k2krnm	1141	9	,	,	,
cord-022353-q2k2krnm	1141	10	adrenal	adrenal	NN
cord-022353-q2k2krnm	1141	11	,	,	,
cord-022353-q2k2krnm	1141	12	liver	liver	NN
cord-022353-q2k2krnm	1141	13	,	,	,
cord-022353-q2k2krnm	1141	14	and	and	CC
cord-022353-q2k2krnm	1141	15	skin	skin	NN
cord-022353-q2k2krnm	1141	16	,	,	,
cord-022353-q2k2krnm	1141	17	although	although	IN
cord-022353-q2k2krnm	1141	18	in	in	IN
cord-022353-q2k2krnm	1141	19	much	much	JJ
cord-022353-q2k2krnm	1141	20	lower	low	JJR
cord-022353-q2k2krnm	1141	21	amounts	amount	NNS
cord-022353-q2k2krnm	1141	22	than	than	IN
cord-022353-q2k2krnm	1141	23	by	by	IN
cord-022353-q2k2krnm	1141	24	the	the	DT
cord-022353-q2k2krnm	1141	25	ovary	ovary	NN
cord-022353-q2k2krnm	1141	26	.	.	.
cord-022353-q2k2krnm	1142	1	E2	E2	NNP
cord-022353-q2k2krnm	1142	2	provides	provide	VBZ
cord-022353-q2k2krnm	1142	3	negative	negative	JJ
cord-022353-q2k2krnm	1142	4	feedback	feedback	NN
cord-022353-q2k2krnm	1142	5	control	control	NN
cord-022353-q2k2krnm	1142	6	over	over	IN
cord-022353-q2k2krnm	1142	7	LH	LH	NNP
cord-022353-q2k2krnm	1142	8	secretion	secretion	NN
cord-022353-q2k2krnm	1142	9	,	,	,
cord-022353-q2k2krnm	1142	10	and	and	CC
cord-022353-q2k2krnm	1142	11	it	-PRON-	PRP
cord-022353-q2k2krnm	1142	12	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	1142	13	PRL	prl	JJ
cord-022353-q2k2krnm	1142	14	secretion	secretion	NN
cord-022353-q2k2krnm	1142	15	in	in	IN
cord-022353-q2k2krnm	1142	16	mice	mouse	NNS
cord-022353-q2k2krnm	1142	17	.	.	.
cord-022353-q2k2krnm	1143	1	E	e	LS
cord-022353-q2k2krnm	1143	2	2	2	CD
cord-022353-q2k2krnm	1143	3	promotes	promote	VBZ
cord-022353-q2k2krnm	1143	4	the	the	DT
cord-022353-q2k2krnm	1143	5	growth	growth	NN
cord-022353-q2k2krnm	1143	6	and	and	CC
cord-022353-q2k2krnm	1143	7	development	development	NN
cord-022353-q2k2krnm	1143	8	of	of	IN
cord-022353-q2k2krnm	1143	9	the	the	DT
cord-022353-q2k2krnm	1143	10	female	female	JJ
cord-022353-q2k2krnm	1143	11	reproductive	reproductive	JJ
cord-022353-q2k2krnm	1143	12	tract	tract	NN
cord-022353-q2k2krnm	1143	13	,	,	,
cord-022353-q2k2krnm	1143	14	external	external	JJ
cord-022353-q2k2krnm	1143	15	genitalia	genitalia	NNS
cord-022353-q2k2krnm	1143	16	,	,	,
cord-022353-q2k2krnm	1143	17	and	and	CC
cord-022353-q2k2krnm	1143	18	the	the	DT
cord-022353-q2k2krnm	1143	19	ductal	ductal	JJ
cord-022353-q2k2krnm	1143	20	system	system	NN
cord-022353-q2k2krnm	1143	21	of	of	IN
cord-022353-q2k2krnm	1143	22	the	the	DT
cord-022353-q2k2krnm	1143	23	mammary	mammary	JJ
cord-022353-q2k2krnm	1143	24	glands	gland	NNS
cord-022353-q2k2krnm	1143	25	.	.	.
cord-022353-q2k2krnm	1144	1	In	in	IN
cord-022353-q2k2krnm	1144	2	addition	addition	NN
cord-022353-q2k2krnm	1144	3	,	,	,
cord-022353-q2k2krnm	1144	4	E	e	NN
cord-022353-q2k2krnm	1144	5	2	2	CD
cord-022353-q2k2krnm	1144	6	sensitizes	sensitize	VBZ
cord-022353-q2k2krnm	1144	7	the	the	DT
cord-022353-q2k2krnm	1144	8	follicle	follicle	NN
cord-022353-q2k2krnm	1144	9	to	to	IN
cord-022353-q2k2krnm	1144	10	FSH	FSH	NNP
cord-022353-q2k2krnm	1144	11	.	.	.
cord-022353-q2k2krnm	1145	1	E	e	LS
cord-022353-q2k2krnm	1145	2	2	2	CD
cord-022353-q2k2krnm	1145	3	is	be	VBZ
cord-022353-q2k2krnm	1145	4	measured	measure	VBN
cord-022353-q2k2krnm	1145	5	in	in	IN
cord-022353-q2k2krnm	1145	6	mice	mouse	NNS
cord-022353-q2k2krnm	1145	7	using	use	VBG
cord-022353-q2k2krnm	1145	8	RIA	RIA	NNP
cord-022353-q2k2krnm	1145	9	and	and	CC
cord-022353-q2k2krnm	1145	10	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1145	11	.	.	.
cord-022353-q2k2krnm	1146	1	High	high	JJ
cord-022353-q2k2krnm	1146	2	circulating	circulate	VBG
cord-022353-q2k2krnm	1146	3	levels	level	NNS
cord-022353-q2k2krnm	1146	4	of	of	IN
cord-022353-q2k2krnm	1146	5	E	e	NN
cord-022353-q2k2krnm	1146	6	2	2	CD
cord-022353-q2k2krnm	1146	7	precede	precede	VBP
cord-022353-q2k2krnm	1146	8	the	the	DT
cord-022353-q2k2krnm	1146	9	preovulatory	preovulatory	JJ
cord-022353-q2k2krnm	1146	10	surge	surge	NN
cord-022353-q2k2krnm	1146	11	in	in	IN
cord-022353-q2k2krnm	1146	12	LH	LH	NNP
cord-022353-q2k2krnm	1146	13	.	.	.
cord-022353-q2k2krnm	1147	1	Ryan	Ryan	NNP
cord-022353-q2k2krnm	1147	2	and	and	CC
cord-022353-q2k2krnm	1147	3	Schwartz	Schwartz	NNP
cord-022353-q2k2krnm	1147	4	(	(	-LRB-
cord-022353-q2k2krnm	1147	5	1980	1980	CD
cord-022353-q2k2krnm	1147	6	)	)	-RRB-
cord-022353-q2k2krnm	1147	7	reported	report	VBN
cord-022353-q2k2krnm	1147	8	basal	basal	NN
cord-022353-q2k2krnm	1147	9	levels	level	NNS
cord-022353-q2k2krnm	1147	10	of	of	IN
cord-022353-q2k2krnm	1147	11	E	e	NN
cord-022353-q2k2krnm	1147	12	2	2	CD
cord-022353-q2k2krnm	1147	13	in	in	IN
cord-022353-q2k2krnm	1147	14	mice	mouse	NNS
cord-022353-q2k2krnm	1147	15	of	of	IN
cord-022353-q2k2krnm	1147	16	1	1	CD
cord-022353-q2k2krnm	1147	17	to	to	IN
cord-022353-q2k2krnm	1147	18	5	5	CD
cord-022353-q2k2krnm	1147	19	pg	pg	NN
cord-022353-q2k2krnm	1147	20	/	/	SYM
cord-022353-q2k2krnm	1147	21	ml	ml	NN
cord-022353-q2k2krnm	1147	22	.	.	.
cord-022353-q2k2krnm	1148	1	Holinka	Holinka	NNP
cord-022353-q2k2krnm	1148	2	et	et	NNP
cord-022353-q2k2krnm	1148	3	al	al	NNP
cord-022353-q2k2krnm	1148	4	.	.	.
cord-022353-q2k2krnm	1149	1	(	(	-LRB-
cord-022353-q2k2krnm	1149	2	1978	1978	CD
cord-022353-q2k2krnm	1149	3	)	)	-RRB-
cord-022353-q2k2krnm	1149	4	studied	study	VBD
cord-022353-q2k2krnm	1149	5	circulating	circulate	VBG
cord-022353-q2k2krnm	1149	6	levels	level	NNS
cord-022353-q2k2krnm	1149	7	of	of	IN
cord-022353-q2k2krnm	1149	8	progesterone	progesterone	NN
cord-022353-q2k2krnm	1149	9	and	and	CC
cord-022353-q2k2krnm	1149	10	estradiol	estradiol	NN
cord-022353-q2k2krnm	1149	11	in	in	IN
cord-022353-q2k2krnm	1149	12	young	young	JJ
cord-022353-q2k2krnm	1149	13	and	and	CC
cord-022353-q2k2krnm	1149	14	old	old	JJ
cord-022353-q2k2krnm	1149	15	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1149	16	female	female	JJ
cord-022353-q2k2krnm	1149	17	mice	mouse	NNS
cord-022353-q2k2krnm	1149	18	during	during	IN
cord-022353-q2k2krnm	1149	19	gestation	gestation	NN
cord-022353-q2k2krnm	1149	20	.	.	.
cord-022353-q2k2krnm	1150	1	They	-PRON-	PRP
cord-022353-q2k2krnm	1150	2	found	find	VBD
cord-022353-q2k2krnm	1150	3	that	that	IN
cord-022353-q2k2krnm	1150	4	the	the	DT
cord-022353-q2k2krnm	1150	5	old	old	JJ
cord-022353-q2k2krnm	1150	6	multiparous	multiparous	JJ
cord-022353-q2k2krnm	1150	7	females	female	NNS
cord-022353-q2k2krnm	1150	8	have	have	VBP
cord-022353-q2k2krnm	1150	9	delayed	delay	VBN
cord-022353-q2k2krnm	1150	10	and	and	CC
cord-022353-q2k2krnm	1150	11	reduced	reduce	VBN
cord-022353-q2k2krnm	1150	12	preparturitional	preparturitional	JJ
cord-022353-q2k2krnm	1150	13	rise	rise	NN
cord-022353-q2k2krnm	1150	14	is	be	VBZ
cord-022353-q2k2krnm	1151	1	plasma	plasma	NN
cord-022353-q2k2krnm	1151	2	E	E	NNP
cord-022353-q2k2krnm	1151	3	2	2	CD
cord-022353-q2k2krnm	1151	4	compared	compare	VBN
cord-022353-q2k2krnm	1151	5	to	to	IN
cord-022353-q2k2krnm	1151	6	young	young	JJ
cord-022353-q2k2krnm	1151	7	females	female	NNS
cord-022353-q2k2krnm	1151	8	.	.	.
cord-022353-q2k2krnm	1152	1	Because	because	IN
cord-022353-q2k2krnm	1152	2	preparturitional	preparturitional	NNP
cord-022353-q2k2krnm	1152	3	E	E	NNP
cord-022353-q2k2krnm	1152	4	2	2	CD
cord-022353-q2k2krnm	1152	5	is	be	VBZ
cord-022353-q2k2krnm	1152	6	thought	think	VBN
cord-022353-q2k2krnm	1152	7	to	to	TO
cord-022353-q2k2krnm	1152	8	regulate	regulate	VB
cord-022353-q2k2krnm	1152	9	uterine	uterine	JJ
cord-022353-q2k2krnm	1152	10	progesterone	progesterone	NN
cord-022353-q2k2krnm	1152	11	levels	level	NNS
cord-022353-q2k2krnm	1152	12	,	,	,
cord-022353-q2k2krnm	1152	13	the	the	DT
cord-022353-q2k2krnm	1152	14	decline	decline	NN
cord-022353-q2k2krnm	1152	15	in	in	IN
cord-022353-q2k2krnm	1152	16	E	e	NN
cord-022353-q2k2krnm	1152	17	2	2	CD
cord-022353-q2k2krnm	1152	18	seen	see	VBN
cord-022353-q2k2krnm	1152	19	in	in	IN
cord-022353-q2k2krnm	1152	20	older	old	JJR
cord-022353-q2k2krnm	1152	21	females	female	NNS
cord-022353-q2k2krnm	1152	22	coupled	couple	VBN
cord-022353-q2k2krnm	1152	23	with	with	IN
cord-022353-q2k2krnm	1152	24	elevated	elevated	JJ
cord-022353-q2k2krnm	1152	25	progesterone	progesterone	NN
cord-022353-q2k2krnm	1152	26	may	may	MD
cord-022353-q2k2krnm	1152	27	delay	delay	VB
cord-022353-q2k2krnm	1152	28	the	the	DT
cord-022353-q2k2krnm	1152	29	onset	onset	NN
cord-022353-q2k2krnm	1152	30	of	of	IN
cord-022353-q2k2krnm	1152	31	labor	labor	NN
cord-022353-q2k2krnm	1152	32	and	and	CC
cord-022353-q2k2krnm	1152	33	lead	lead	NN
cord-022353-q2k2krnm	1152	34	to	to	IN
cord-022353-q2k2krnm	1152	35	prolonged	prolong	VBN
cord-022353-q2k2krnm	1152	36	gestation	gestation	NN
cord-022353-q2k2krnm	1152	37	.	.	.
cord-022353-q2k2krnm	1153	1	When	when	WRB
cord-022353-q2k2krnm	1153	2	sex	sex	NN
cord-022353-q2k2krnm	1153	3	steroid	steroid	NN
cord-022353-q2k2krnm	1153	4	hormones	hormone	NNS
cord-022353-q2k2krnm	1153	5	such	such	JJ
cord-022353-q2k2krnm	1153	6	as	as	IN
cord-022353-q2k2krnm	1153	7	E	e	NN
cord-022353-q2k2krnm	1153	8	2	2	CD
cord-022353-q2k2krnm	1153	9	bind	bind	VBP
cord-022353-q2k2krnm	1153	10	their	-PRON-	PRP$
cord-022353-q2k2krnm	1153	11	receptor	receptor	NN
cord-022353-q2k2krnm	1153	12	,	,	,
cord-022353-q2k2krnm	1153	13	they	-PRON-	PRP
cord-022353-q2k2krnm	1153	14	induce	induce	VBP
cord-022353-q2k2krnm	1153	15	a	a	DT
cord-022353-q2k2krnm	1153	16	conformational	conformational	JJ
cord-022353-q2k2krnm	1153	17	change	change	NN
cord-022353-q2k2krnm	1153	18	that	that	WDT
cord-022353-q2k2krnm	1153	19	allows	allow	VBZ
cord-022353-q2k2krnm	1153	20	the	the	DT
cord-022353-q2k2krnm	1153	21	complex	complex	NN
cord-022353-q2k2krnm	1153	22	to	to	TO
cord-022353-q2k2krnm	1153	23	bind	bind	VB
cord-022353-q2k2krnm	1153	24	DNA	dna	NN
cord-022353-q2k2krnm	1153	25	response	response	NN
cord-022353-q2k2krnm	1153	26	elements	element	NNS
cord-022353-q2k2krnm	1153	27	on	on	IN
cord-022353-q2k2krnm	1153	28	nuclear	nuclear	JJ
cord-022353-q2k2krnm	1153	29	target	target	NN
cord-022353-q2k2krnm	1153	30	genes	gene	NNS
cord-022353-q2k2krnm	1153	31	and	and	CC
cord-022353-q2k2krnm	1153	32	associate	associate	VBP
cord-022353-q2k2krnm	1153	33	with	with	IN
cord-022353-q2k2krnm	1153	34	coactivators	coactivator	NNS
cord-022353-q2k2krnm	1153	35	and	and	CC
cord-022353-q2k2krnm	1153	36	transcription	transcription	NN
cord-022353-q2k2krnm	1153	37	factors	factor	NNS
cord-022353-q2k2krnm	1153	38	to	to	TO
cord-022353-q2k2krnm	1153	39	form	form	VB
cord-022353-q2k2krnm	1153	40	an	an	DT
cord-022353-q2k2krnm	1153	41	active	active	JJ
cord-022353-q2k2krnm	1153	42	transcriptional	transcriptional	JJ
cord-022353-q2k2krnm	1153	43	complex	complex	NN
cord-022353-q2k2krnm	1153	44	.	.	.
cord-022353-q2k2krnm	1154	1	This	this	DT
cord-022353-q2k2krnm	1154	2	complex	complex	NN
cord-022353-q2k2krnm	1154	3	is	be	VBZ
cord-022353-q2k2krnm	1154	4	responsible	responsible	JJ
cord-022353-q2k2krnm	1154	5	for	for	IN
cord-022353-q2k2krnm	1154	6	initiating	initiate	VBG
cord-022353-q2k2krnm	1154	7	the	the	DT
cord-022353-q2k2krnm	1154	8	transcription	transcription	NN
cord-022353-q2k2krnm	1154	9	of	of	IN
cord-022353-q2k2krnm	1154	10	the	the	DT
cord-022353-q2k2krnm	1154	11	target	target	NN
cord-022353-q2k2krnm	1154	12	gene	gene	NN
cord-022353-q2k2krnm	1154	13	.	.	.
cord-022353-q2k2krnm	1155	1	One	one	CD
cord-022353-q2k2krnm	1155	2	coactivator	coactivator	NN
cord-022353-q2k2krnm	1155	3	that	that	WDT
cord-022353-q2k2krnm	1155	4	associates	associate	NNS
cord-022353-q2k2krnm	1155	5	with	with	IN
cord-022353-q2k2krnm	1155	6	the	the	DT
cord-022353-q2k2krnm	1155	7	active	active	JJ
cord-022353-q2k2krnm	1155	8	transcriptional	transcriptional	NN
cord-022353-q2k2krnm	1155	9	complex	complex	JJ
cord-022353-q2k2krnm	1155	10	involving	involve	VBG
cord-022353-q2k2krnm	1155	11	sex	sex	NN
cord-022353-q2k2krnm	1155	12	hormones	hormone	NNS
cord-022353-q2k2krnm	1155	13	is	be	VBZ
cord-022353-q2k2krnm	1155	14	steroid	steroid	NN
cord-022353-q2k2krnm	1155	15	receptor	receptor	NN
cord-022353-q2k2krnm	1155	16	coactivator-1	coactivator-1	NNP
cord-022353-q2k2krnm	1155	17	(	(	-LRB-
cord-022353-q2k2krnm	1155	18	SRC-1	SRC-1	NNP
cord-022353-q2k2krnm	1155	19	)	)	-RRB-
cord-022353-q2k2krnm	1155	20	.	.	.
cord-022353-q2k2krnm	1156	1	To	to	TO
cord-022353-q2k2krnm	1156	2	better	well	RBR
cord-022353-q2k2krnm	1156	3	understand	understand	VB
cord-022353-q2k2krnm	1156	4	its	-PRON-	PRP$
cord-022353-q2k2krnm	1156	5	physiologic	physiologic	JJ
cord-022353-q2k2krnm	1156	6	role	role	NN
cord-022353-q2k2krnm	1156	7	during	during	IN
cord-022353-q2k2krnm	1156	8	sex	sex	NN
cord-022353-q2k2krnm	1156	9	hormone	hormone	NN
cord-022353-q2k2krnm	1156	10	-	-	HYPH
cord-022353-q2k2krnm	1156	11	receptor	receptor	NN
cord-022353-q2k2krnm	1156	12	binding	binding	NN
cord-022353-q2k2krnm	1156	13	,	,	,
cord-022353-q2k2krnm	1156	14	KO	KO	NNP
cord-022353-q2k2krnm	1156	15	mice	mouse	NNS
cord-022353-q2k2krnm	1156	16	that	that	WDT
cord-022353-q2k2krnm	1156	17	were	be	VBD
cord-022353-q2k2krnm	1156	18	deficient	deficient	JJ
cord-022353-q2k2krnm	1156	19	in	in	IN
cord-022353-q2k2krnm	1156	20	SRC-1	SRC-1	NNS
cord-022353-q2k2krnm	1156	21	were	be	VBD
cord-022353-q2k2krnm	1156	22	created	create	VBN
cord-022353-q2k2krnm	1157	1	(	(	-LRB-
cord-022353-q2k2krnm	1157	2	Xu	Xu	NNP
cord-022353-q2k2krnm	1157	3	et	et	NNP
cord-022353-q2k2krnm	1157	4	al	al	NNP
cord-022353-q2k2krnm	1157	5	.	.	NNP
cord-022353-q2k2krnm	1157	6	1998	1998	CD
cord-022353-q2k2krnm	1157	7	)	)	-RRB-
cord-022353-q2k2krnm	1157	8	.	.	.
cord-022353-q2k2krnm	1158	1	Deficient	deficient	JJ
cord-022353-q2k2krnm	1158	2	male	male	JJ
cord-022353-q2k2krnm	1158	3	mice	mouse	NNS
cord-022353-q2k2krnm	1158	4	had	have	VBD
cord-022353-q2k2krnm	1158	5	a	a	DT
cord-022353-q2k2krnm	1158	6	34	34	CD
cord-022353-q2k2krnm	1158	7	%	%	NN
cord-022353-q2k2krnm	1158	8	reduction	reduction	NN
cord-022353-q2k2krnm	1158	9	in	in	IN
cord-022353-q2k2krnm	1158	10	testosterone	testosterone	NN
cord-022353-q2k2krnm	1158	11	-	-	HYPH
cord-022353-q2k2krnm	1158	12	stimulated	stimulate	VBN
cord-022353-q2k2krnm	1158	13	prostate	prostate	NN
cord-022353-q2k2krnm	1158	14	growth	growth	NN
cord-022353-q2k2krnm	1158	15	and	and	CC
cord-022353-q2k2krnm	1158	16	small	small	JJ
cord-022353-q2k2krnm	1158	17	testes	testis	NNS
cord-022353-q2k2krnm	1158	18	compared	compare	VBN
cord-022353-q2k2krnm	1158	19	to	to	IN
cord-022353-q2k2krnm	1158	20	wild	wild	JJ
cord-022353-q2k2krnm	1158	21	-	-	HYPH
cord-022353-q2k2krnm	1158	22	type	type	NN
cord-022353-q2k2krnm	1158	23	mice	mouse	NNS
cord-022353-q2k2krnm	1158	24	.	.	.
cord-022353-q2k2krnm	1159	1	Deficient	deficient	JJ
cord-022353-q2k2krnm	1159	2	females	female	NNS
cord-022353-q2k2krnm	1159	3	had	have	VBD
cord-022353-q2k2krnm	1159	4	a	a	DT
cord-022353-q2k2krnm	1159	5	half	half	RB
cord-022353-q2k2krnm	1159	6	-	-	HYPH
cord-022353-q2k2krnm	1159	7	normal	normal	JJ
cord-022353-q2k2krnm	1159	8	uterine	uterine	JJ
cord-022353-q2k2krnm	1159	9	growth	growth	NN
cord-022353-q2k2krnm	1159	10	response	response	NN
cord-022353-q2k2krnm	1159	11	to	to	IN
cord-022353-q2k2krnm	1159	12	exogenous	exogenous	JJ
cord-022353-q2k2krnm	1159	13	E	E	NNP
cord-022353-q2k2krnm	1159	14	2	2	CD
cord-022353-q2k2krnm	1159	15	and	and	CC
cord-022353-q2k2krnm	1159	16	only	only	RB
cord-022353-q2k2krnm	1159	17	a	a	DT
cord-022353-q2k2krnm	1159	18	partial	partial	JJ
cord-022353-q2k2krnm	1159	19	ductal	ductal	JJ
cord-022353-q2k2krnm	1159	20	growth	growth	NN
cord-022353-q2k2krnm	1159	21	response	response	NN
cord-022353-q2k2krnm	1159	22	(	(	-LRB-
cord-022353-q2k2krnm	1159	23	in	in	IN
cord-022353-q2k2krnm	1159	24	the	the	DT
cord-022353-q2k2krnm	1159	25	mammary	mammary	JJ
cord-022353-q2k2krnm	1159	26	gland	gland	NN
cord-022353-q2k2krnm	1159	27	)	)	-RRB-
cord-022353-q2k2krnm	1159	28	following	follow	VBG
cord-022353-q2k2krnm	1159	29	exogenous	exogenous	JJ
cord-022353-q2k2krnm	1159	30	E	e	NN
cord-022353-q2k2krnm	1159	31	2	2	CD
cord-022353-q2k2krnm	1159	32	and	and	CC
cord-022353-q2k2krnm	1159	33	progesterone	progesterone	NN
cord-022353-q2k2krnm	1159	34	.	.	.
cord-022353-q2k2krnm	1160	1	Serum	serum	NN
cord-022353-q2k2krnm	1160	2	concentrations	concentration	NNS
cord-022353-q2k2krnm	1160	3	of	of	IN
cord-022353-q2k2krnm	1160	4	E	e	NN
cord-022353-q2k2krnm	1160	5	2	2	CD
cord-022353-q2k2krnm	1160	6	and	and	CC
cord-022353-q2k2krnm	1160	7	testosterone	testosterone	NN
cord-022353-q2k2krnm	1160	8	were	be	VBD
cord-022353-q2k2krnm	1160	9	elevated	elevate	VBN
cord-022353-q2k2krnm	1160	10	1.2	1.2	CD
cord-022353-q2k2krnm	1160	11	to	to	TO
cord-022353-q2k2krnm	1160	12	1.5	1.5	CD
cord-022353-q2k2krnm	1160	13	times	time	NNS
cord-022353-q2k2krnm	1160	14	wild	wild	JJ
cord-022353-q2k2krnm	1160	15	-	-	HYPH
cord-022353-q2k2krnm	1160	16	type	type	NN
cord-022353-q2k2krnm	1160	17	levels	level	NNS
cord-022353-q2k2krnm	1160	18	,	,	,
cord-022353-q2k2krnm	1160	19	indicating	indicate	VBG
cord-022353-q2k2krnm	1160	20	an	an	DT
cord-022353-q2k2krnm	1160	21	abnormality	abnormality	NN
cord-022353-q2k2krnm	1160	22	in	in	IN
cord-022353-q2k2krnm	1160	23	the	the	DT
cord-022353-q2k2krnm	1160	24	endocrine	endocrine	JJ
cord-022353-q2k2krnm	1160	25	feedback	feedback	NN
cord-022353-q2k2krnm	1160	26	control	control	NN
cord-022353-q2k2krnm	1160	27	system	system	NN
cord-022353-q2k2krnm	1160	28	.	.	.
cord-022353-q2k2krnm	1161	1	Although	although	IN
cord-022353-q2k2krnm	1161	2	SRC-1	SRC-1	NNP
cord-022353-q2k2krnm	1161	3	was	be	VBD
cord-022353-q2k2krnm	1161	4	shown	show	VBN
cord-022353-q2k2krnm	1161	5	to	to	TO
cord-022353-q2k2krnm	1161	6	clearly	clearly	RB
cord-022353-q2k2krnm	1161	7	be	be	VB
cord-022353-q2k2krnm	1161	8	necessary	necessary	JJ
cord-022353-q2k2krnm	1161	9	for	for	IN
cord-022353-q2k2krnm	1161	10	optimal	optimal	JJ
cord-022353-q2k2krnm	1161	11	sex	sex	NN
cord-022353-q2k2krnm	1161	12	hormone	hormone	NN
cord-022353-q2k2krnm	1161	13	-	-	HYPH
cord-022353-q2k2krnm	1161	14	induced	induce	VBN
cord-022353-q2k2krnm	1161	15	cellular	cellular	JJ
cord-022353-q2k2krnm	1161	16	activation	activation	NN
cord-022353-q2k2krnm	1161	17	,	,	,
cord-022353-q2k2krnm	1161	18	the	the	DT
cord-022353-q2k2krnm	1161	19	lesion	lesion	NN
cord-022353-q2k2krnm	1161	20	created	create	VBN
cord-022353-q2k2krnm	1161	21	in	in	IN
cord-022353-q2k2krnm	1161	22	this	this	DT
cord-022353-q2k2krnm	1161	23	KO	KO	NNP
cord-022353-q2k2krnm	1161	24	mouse	mouse	NN
cord-022353-q2k2krnm	1161	25	was	be	VBD
cord-022353-q2k2krnm	1161	26	not	not	RB
cord-022353-q2k2krnm	1161	27	nearly	nearly	RB
cord-022353-q2k2krnm	1161	28	as	as	RB
cord-022353-q2k2krnm	1161	29	profound	profound	JJ
cord-022353-q2k2krnm	1161	30	as	as	IN
cord-022353-q2k2krnm	1161	31	that	that	DT
cord-022353-q2k2krnm	1161	32	seen	see	VBN
cord-022353-q2k2krnm	1161	33	in	in	IN
cord-022353-q2k2krnm	1161	34	mice	mouse	NNS
cord-022353-q2k2krnm	1161	35	with	with	IN
cord-022353-q2k2krnm	1161	36	disrupted	disrupt	VBN
cord-022353-q2k2krnm	1161	37	E	e	NN
cord-022353-q2k2krnm	1161	38	2	2	CD
cord-022353-q2k2krnm	1161	39	receptors	receptor	NNS
cord-022353-q2k2krnm	1161	40	(	(	-LRB-
cord-022353-q2k2krnm	1161	41	Korach	Korach	NNP
cord-022353-q2k2krnm	1161	42	et	et	FW
cord-022353-q2k2krnm	1161	43	al	al	NNP
cord-022353-q2k2krnm	1161	44	.	.	.
cord-022353-q2k2krnm	1161	45	1996	1996	CD
cord-022353-q2k2krnm	1161	46	)	)	-RRB-
cord-022353-q2k2krnm	1161	47	.	.	.
cord-022353-q2k2krnm	1162	1	Mice	mouse	NNS
cord-022353-q2k2krnm	1162	2	with	with	IN
cord-022353-q2k2krnm	1162	3	the	the	DT
cord-022353-q2k2krnm	1162	4	genes	gene	NNS
cord-022353-q2k2krnm	1162	5	for	for	IN
cord-022353-q2k2krnm	1162	6	the	the	DT
cord-022353-q2k2krnm	1162	7	E	e	NN
cord-022353-q2k2krnm	1162	8	2	2	CD
cord-022353-q2k2krnm	1162	9	receptors	receptor	NNS
cord-022353-q2k2krnm	1162	10	and	and	CC
cord-022353-q2k2krnm	1162	11	aromatase	aromatase	NN
cord-022353-q2k2krnm	1162	12	knocked	knock	VBD
cord-022353-q2k2krnm	1162	13	out	out	RP
cord-022353-q2k2krnm	1162	14	have	have	VBP
cord-022353-q2k2krnm	1162	15	been	be	VBN
cord-022353-q2k2krnm	1162	16	described	describe	VBN
cord-022353-q2k2krnm	1162	17	(	(	-LRB-
cord-022353-q2k2krnm	1162	18	Simpson	Simpson	NNP
cord-022353-q2k2krnm	1162	19	et	et	NNP
cord-022353-q2k2krnm	1162	20	al	al	NNP
cord-022353-q2k2krnm	1162	21	.	.	.
cord-022353-q2k2krnm	1162	22	2005	2005	CD
cord-022353-q2k2krnm	1163	1	Synthesized	synthesize	VBN
cord-022353-q2k2krnm	1163	2	by	by	IN
cord-022353-q2k2krnm	1163	3	the	the	DT
cord-022353-q2k2krnm	1163	4	corpus	corpus	NNP
cord-022353-q2k2krnm	1163	5	luteum	luteum	NN
cord-022353-q2k2krnm	1163	6	before	before	IN
cord-022353-q2k2krnm	1163	7	implantation	implantation	NN
cord-022353-q2k2krnm	1163	8	and	and	CC
cord-022353-q2k2krnm	1163	9	by	by	IN
cord-022353-q2k2krnm	1163	10	both	both	DT
cord-022353-q2k2krnm	1163	11	corpus	corpus	NNP
cord-022353-q2k2krnm	1163	12	luteum	luteum	NN
cord-022353-q2k2krnm	1163	13	and	and	CC
cord-022353-q2k2krnm	1163	14	placenta	placenta	NN
cord-022353-q2k2krnm	1163	15	following	follow	VBG
cord-022353-q2k2krnm	1163	16	implantation	implantation	NN
cord-022353-q2k2krnm	1163	17	,	,	,
cord-022353-q2k2krnm	1163	18	progesterone	progesterone	NN
cord-022353-q2k2krnm	1163	19	is	be	VBZ
cord-022353-q2k2krnm	1163	20	necessary	necessary	JJ
cord-022353-q2k2krnm	1163	21	for	for	IN
cord-022353-q2k2krnm	1163	22	preparing	prepare	VBG
cord-022353-q2k2krnm	1163	23	the	the	DT
cord-022353-q2k2krnm	1163	24	uterus	uterus	NN
cord-022353-q2k2krnm	1163	25	for	for	IN
cord-022353-q2k2krnm	1163	26	implantation	implantation	NN
cord-022353-q2k2krnm	1163	27	and	and	CC
cord-022353-q2k2krnm	1163	28	maintaining	maintain	VBG
cord-022353-q2k2krnm	1163	29	pregnancy	pregnancy	NN
cord-022353-q2k2krnm	1163	30	.	.	.
cord-022353-q2k2krnm	1164	1	In	in	IN
cord-022353-q2k2krnm	1164	2	addition	addition	NN
cord-022353-q2k2krnm	1164	3	,	,	,
cord-022353-q2k2krnm	1164	4	a	a	DT
cord-022353-q2k2krnm	1164	5	small	small	JJ
cord-022353-q2k2krnm	1164	6	amount	amount	NN
cord-022353-q2k2krnm	1164	7	of	of	IN
cord-022353-q2k2krnm	1164	8	progesterone	progesterone	NN
cord-022353-q2k2krnm	1164	9	is	be	VBZ
cord-022353-q2k2krnm	1164	10	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1164	11	by	by	IN
cord-022353-q2k2krnm	1164	12	the	the	DT
cord-022353-q2k2krnm	1164	13	adrenal	adrenal	JJ
cord-022353-q2k2krnm	1164	14	gland	gland	NN
cord-022353-q2k2krnm	1164	15	.	.	.
cord-022353-q2k2krnm	1165	1	Activation	activation	NN
cord-022353-q2k2krnm	1165	2	of	of	IN
cord-022353-q2k2krnm	1165	3	the	the	DT
cord-022353-q2k2krnm	1165	4	corpus	corpus	NNP
cord-022353-q2k2krnm	1165	5	luteum	luteum	NN
cord-022353-q2k2krnm	1165	6	to	to	TO
cord-022353-q2k2krnm	1165	7	secrete	secrete	VB
cord-022353-q2k2krnm	1165	8	progesterone	progesterone	NN
cord-022353-q2k2krnm	1165	9	requires	require	VBZ
cord-022353-q2k2krnm	1165	10	both	both	CC
cord-022353-q2k2krnm	1165	11	LH	LH	NNP
cord-022353-q2k2krnm	1165	12	and	and	CC
cord-022353-q2k2krnm	1165	13	PRL	PRL	NNP
cord-022353-q2k2krnm	1165	14	.	.	.
cord-022353-q2k2krnm	1166	1	Progesterone	progesterone	NN
cord-022353-q2k2krnm	1166	2	provides	provide	VBZ
cord-022353-q2k2krnm	1166	3	negative	negative	JJ
cord-022353-q2k2krnm	1166	4	feedback	feedback	NN
cord-022353-q2k2krnm	1166	5	control	control	NN
cord-022353-q2k2krnm	1166	6	over	over	IN
cord-022353-q2k2krnm	1166	7	LH	LH	NNP
cord-022353-q2k2krnm	1166	8	.	.	.
cord-022353-q2k2krnm	1167	1	In	in	IN
cord-022353-q2k2krnm	1167	2	mice	mouse	NNS
cord-022353-q2k2krnm	1167	3	,	,	,
cord-022353-q2k2krnm	1167	4	progesterone	progesterone	NN
cord-022353-q2k2krnm	1167	5	is	be	VBZ
cord-022353-q2k2krnm	1167	6	measured	measure	VBN
cord-022353-q2k2krnm	1167	7	using	use	VBG
cord-022353-q2k2krnm	1167	8	RIA	RIA	NNP
cord-022353-q2k2krnm	1167	9	or	or	CC
cord-022353-q2k2krnm	1167	10	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1167	11	.	.	.
cord-022353-q2k2krnm	1168	1	In	in	IN
cord-022353-q2k2krnm	1168	2	cycling	cycling	NN
cord-022353-q2k2krnm	1168	3	mice	mouse	NNS
cord-022353-q2k2krnm	1168	4	,	,	,
cord-022353-q2k2krnm	1168	5	the	the	DT
cord-022353-q2k2krnm	1168	6	levels	level	NNS
cord-022353-q2k2krnm	1168	7	of	of	IN
cord-022353-q2k2krnm	1168	8	progesterone	progesterone	NN
cord-022353-q2k2krnm	1168	9	increased	increase	VBD
cord-022353-q2k2krnm	1168	10	from	from	IN
cord-022353-q2k2krnm	1168	11	5	5	CD
cord-022353-q2k2krnm	1168	12	to	to	IN
cord-022353-q2k2krnm	1168	13	35	35	CD
cord-022353-q2k2krnm	1168	14	ng	ng	NN
cord-022353-q2k2krnm	1168	15	/	/	SYM
cord-022353-q2k2krnm	1168	16	ml	ml	NNP
cord-022353-q2k2krnm	1168	17	on	on	IN
cord-022353-q2k2krnm	1168	18	proestrus	proestrus	NNP
cord-022353-q2k2krnm	1168	19	and	and	CC
cord-022353-q2k2krnm	1168	20	returned	return	VBD
cord-022353-q2k2krnm	1168	21	back	back	RB
cord-022353-q2k2krnm	1168	22	to	to	IN
cord-022353-q2k2krnm	1168	23	baseline	baseline	NN
cord-022353-q2k2krnm	1168	24	on	on	IN
cord-022353-q2k2krnm	1168	25	estrus	estrus	NN
cord-022353-q2k2krnm	1168	26	.	.	.
cord-022353-q2k2krnm	1169	1	Flurkey	Flurkey	NNP
cord-022353-q2k2krnm	1169	2	et	et	NNP
cord-022353-q2k2krnm	1169	3	al	al	NNP
cord-022353-q2k2krnm	1169	4	.	.	.
cord-022353-q2k2krnm	1170	1	(	(	-LRB-
cord-022353-q2k2krnm	1170	2	1982	1982	CD
cord-022353-q2k2krnm	1170	3	)	)	-RRB-
cord-022353-q2k2krnm	1170	4	compared	compare	VBD
cord-022353-q2k2krnm	1170	5	the	the	DT
cord-022353-q2k2krnm	1170	6	plasma	plasma	NN
cord-022353-q2k2krnm	1170	7	levels	level	NNS
cord-022353-q2k2krnm	1170	8	of	of	IN
cord-022353-q2k2krnm	1170	9	LH	LH	NNP
cord-022353-q2k2krnm	1170	10	,	,	,
cord-022353-q2k2krnm	1170	11	progesterone	progesterone	NN
cord-022353-q2k2krnm	1170	12	,	,	,
cord-022353-q2k2krnm	1170	13	and	and	CC
cord-022353-q2k2krnm	1170	14	PRL	PRL	NNP
cord-022353-q2k2krnm	1170	15	in	in	IN
cord-022353-q2k2krnm	1170	16	cycling	cycle	VBG
cord-022353-q2k2krnm	1170	17	young	young	JJ
cord-022353-q2k2krnm	1170	18	(	(	-LRB-
cord-022353-q2k2krnm	1170	19	10-week	10-week	JJ
cord-022353-q2k2krnm	1170	20	)	)	-RRB-
cord-022353-q2k2krnm	1170	21	and	and	CC
cord-022353-q2k2krnm	1170	22	old	old	JJ
cord-022353-q2k2krnm	1170	23	(	(	-LRB-
cord-022353-q2k2krnm	1170	24	8month	8month	JJ
cord-022353-q2k2krnm	1170	25	)	)	-RRB-
cord-022353-q2k2krnm	1170	26	female	female	JJ
cord-022353-q2k2krnm	1170	27	C57BL/6J	C57BL/6J	NNP
cord-022353-q2k2krnm	1170	28	mice	mouse	NNS
cord-022353-q2k2krnm	1170	29	.	.	.
cord-022353-q2k2krnm	1171	1	They	-PRON-	PRP
cord-022353-q2k2krnm	1171	2	showed	show	VBD
cord-022353-q2k2krnm	1171	3	age	age	NN
cord-022353-q2k2krnm	1171	4	-	-	HYPH
cord-022353-q2k2krnm	1171	5	related	relate	VBN
cord-022353-q2k2krnm	1171	6	deficits	deficit	NNS
cord-022353-q2k2krnm	1171	7	in	in	IN
cord-022353-q2k2krnm	1171	8	the	the	DT
cord-022353-q2k2krnm	1171	9	preovulatory	preovulatory	JJ
cord-022353-q2k2krnm	1171	10	levels	level	NNS
cord-022353-q2k2krnm	1171	11	of	of	IN
cord-022353-q2k2krnm	1171	12	all	all	DT
cord-022353-q2k2krnm	1171	13	three	three	CD
cord-022353-q2k2krnm	1171	14	hormones	hormone	NNS
cord-022353-q2k2krnm	1171	15	.	.	.
cord-022353-q2k2krnm	1172	1	The	the	DT
cord-022353-q2k2krnm	1172	2	LH	LH	NNP
cord-022353-q2k2krnm	1172	3	elevations	elevation	NNS
cord-022353-q2k2krnm	1172	4	during	during	IN
cord-022353-q2k2krnm	1172	5	the	the	DT
cord-022353-q2k2krnm	1172	6	ascending	ascend	VBG
cord-022353-q2k2krnm	1172	7	and	and	CC
cord-022353-q2k2krnm	1172	8	descending	descend	VBG
cord-022353-q2k2krnm	1172	9	portions	portion	NNS
cord-022353-q2k2krnm	1172	10	of	of	IN
cord-022353-q2k2krnm	1172	11	the	the	DT
cord-022353-q2k2krnm	1172	12	preovulatory	preovulatory	JJ
cord-022353-q2k2krnm	1172	13	surge	surge	NN
cord-022353-q2k2krnm	1172	14	were	be	VBD
cord-022353-q2k2krnm	1172	15	smaller	small	JJR
cord-022353-q2k2krnm	1172	16	;	;	:
cord-022353-q2k2krnm	1172	17	the	the	DT
cord-022353-q2k2krnm	1172	18	slower	slow	JJR
cord-022353-q2k2krnm	1172	19	rises	rise	NNS
cord-022353-q2k2krnm	1172	20	in	in	IN
cord-022353-q2k2krnm	1172	21	LH	lh	NN
cord-022353-q2k2krnm	1172	22	during	during	IN
cord-022353-q2k2krnm	1172	23	the	the	DT
cord-022353-q2k2krnm	1172	24	ascending	ascending	JJ
cord-022353-q2k2krnm	1172	25	phase	phase	NN
cord-022353-q2k2krnm	1172	26	of	of	IN
cord-022353-q2k2krnm	1172	27	the	the	DT
cord-022353-q2k2krnm	1172	28	surge	surge	NN
cord-022353-q2k2krnm	1172	29	correlated	correlate	VBN
cord-022353-q2k2krnm	1172	30	with	with	IN
cord-022353-q2k2krnm	1172	31	decreased	decrease	VBN
cord-022353-q2k2krnm	1172	32	progesterone	progesterone	NN
cord-022353-q2k2krnm	1172	33	in	in	IN
cord-022353-q2k2krnm	1172	34	older	old	JJR
cord-022353-q2k2krnm	1172	35	females	female	NNS
cord-022353-q2k2krnm	1172	36	.	.	.
cord-022353-q2k2krnm	1173	1	There	there	EX
cord-022353-q2k2krnm	1173	2	was	be	VBD
cord-022353-q2k2krnm	1173	3	no	no	DT
cord-022353-q2k2krnm	1173	4	correlation	correlation	NN
cord-022353-q2k2krnm	1173	5	between	between	IN
cord-022353-q2k2krnm	1173	6	LH	LH	NNP
cord-022353-q2k2krnm	1173	7	or	or	CC
cord-022353-q2k2krnm	1173	8	progesterone	progesterone	NN
cord-022353-q2k2krnm	1173	9	level	level	NN
cord-022353-q2k2krnm	1173	10	and	and	CC
cord-022353-q2k2krnm	1173	11	length	length	NN
cord-022353-q2k2krnm	1173	12	of	of	IN
cord-022353-q2k2krnm	1173	13	estrus	estrus	NN
cord-022353-q2k2krnm	1173	14	cycle	cycle	NN
cord-022353-q2k2krnm	1173	15	.	.	.
cord-022353-q2k2krnm	1174	1	Holinka	Holinka	NNP
cord-022353-q2k2krnm	1174	2	et	et	NNP
cord-022353-q2k2krnm	1174	3	al	al	NNP
cord-022353-q2k2krnm	1174	4	.	.	.
cord-022353-q2k2krnm	1175	1	(	(	-LRB-
cord-022353-q2k2krnm	1175	2	1978	1978	CD
cord-022353-q2k2krnm	1175	3	)	)	-RRB-
cord-022353-q2k2krnm	1175	4	observed	observe	VBD
cord-022353-q2k2krnm	1175	5	changes	change	NNS
cord-022353-q2k2krnm	1175	6	in	in	IN
cord-022353-q2k2krnm	1175	7	plasma	plasma	NN
cord-022353-q2k2krnm	1175	8	progesterone	progesterone	NN
cord-022353-q2k2krnm	1175	9	levels	level	NNS
cord-022353-q2k2krnm	1175	10	in	in	IN
cord-022353-q2k2krnm	1175	11	young	young	JJ
cord-022353-q2k2krnm	1175	12	and	and	CC
cord-022353-q2k2krnm	1175	13	old	old	JJ
cord-022353-q2k2krnm	1175	14	female	female	JJ
cord-022353-q2k2krnm	1175	15	mice	mouse	NNS
cord-022353-q2k2krnm	1175	16	during	during	IN
cord-022353-q2k2krnm	1175	17	gestation	gestation	NN
cord-022353-q2k2krnm	1175	18	.	.	.
cord-022353-q2k2krnm	1176	1	Older	old	JJR
cord-022353-q2k2krnm	1176	2	mothers	mother	NNS
cord-022353-q2k2krnm	1176	3	had	have	VBD
cord-022353-q2k2krnm	1176	4	a	a	DT
cord-022353-q2k2krnm	1176	5	much	much	RB
cord-022353-q2k2krnm	1176	6	slower	slow	JJR
cord-022353-q2k2krnm	1176	7	decline	decline	NN
cord-022353-q2k2krnm	1176	8	in	in	IN
cord-022353-q2k2krnm	1176	9	circulating	circulate	VBG
cord-022353-q2k2krnm	1176	10	progesterone	progesterone	NN
cord-022353-q2k2krnm	1176	11	than	than	IN
cord-022353-q2k2krnm	1176	12	younger	young	JJR
cord-022353-q2k2krnm	1176	13	mothers	mother	NNS
cord-022353-q2k2krnm	1176	14	between	between	IN
cord-022353-q2k2krnm	1176	15	gestational	gestational	JJ
cord-022353-q2k2krnm	1176	16	days	day	NNS
cord-022353-q2k2krnm	1176	17	17	17	CD
cord-022353-q2k2krnm	1176	18	-	-	SYM
cord-022353-q2k2krnm	1176	19	23	23	CD
cord-022353-q2k2krnm	1176	20	.	.	.
cord-022353-q2k2krnm	1177	1	Because	because	IN
cord-022353-q2k2krnm	1177	2	a	a	DT
cord-022353-q2k2krnm	1177	3	major	major	JJ
cord-022353-q2k2krnm	1177	4	decrease	decrease	NN
cord-022353-q2k2krnm	1177	5	in	in	IN
cord-022353-q2k2krnm	1177	6	plasma	plasma	NN
cord-022353-q2k2krnm	1177	7	progesterone	progesterone	NN
cord-022353-q2k2krnm	1177	8	is	be	VBZ
cord-022353-q2k2krnm	1177	9	thought	think	VBN
cord-022353-q2k2krnm	1177	10	to	to	TO
cord-022353-q2k2krnm	1177	11	be	be	VB
cord-022353-q2k2krnm	1177	12	essential	essential	JJ
cord-022353-q2k2krnm	1177	13	for	for	IN
cord-022353-q2k2krnm	1177	14	the	the	DT
cord-022353-q2k2krnm	1177	15	onset	onset	NN
cord-022353-q2k2krnm	1177	16	of	of	IN
cord-022353-q2k2krnm	1177	17	uterine	uterine	JJ
cord-022353-q2k2krnm	1177	18	contractions	contraction	NNS
cord-022353-q2k2krnm	1177	19	and	and	CC
cord-022353-q2k2krnm	1177	20	parturition	parturition	NN
cord-022353-q2k2krnm	1177	21	in	in	IN
cord-022353-q2k2krnm	1177	22	mice	mouse	NNS
cord-022353-q2k2krnm	1177	23	,	,	,
cord-022353-q2k2krnm	1177	24	the	the	DT
cord-022353-q2k2krnm	1177	25	authors	author	NNS
cord-022353-q2k2krnm	1177	26	hypothesized	hypothesize	VBD
cord-022353-q2k2krnm	1177	27	that	that	IN
cord-022353-q2k2krnm	1177	28	the	the	DT
cord-022353-q2k2krnm	1177	29	attenuated	attenuated	JJ
cord-022353-q2k2krnm	1177	30	decline	decline	NN
cord-022353-q2k2krnm	1177	31	in	in	IN
cord-022353-q2k2krnm	1177	32	older	old	JJR
cord-022353-q2k2krnm	1177	33	mothers	mother	NNS
cord-022353-q2k2krnm	1177	34	may	may	MD
cord-022353-q2k2krnm	1177	35	account	account	VB
cord-022353-q2k2krnm	1177	36	for	for	IN
cord-022353-q2k2krnm	1177	37	their	-PRON-	PRP$
cord-022353-q2k2krnm	1177	38	prolonged	prolong	VBN
cord-022353-q2k2krnm	1177	39	gestation	gestation	NN
cord-022353-q2k2krnm	1177	40	.	.	.
cord-022353-q2k2krnm	1178	1	Surgimoto	Surgimoto	NNP
cord-022353-q2k2krnm	1178	2	et	et	FW
cord-022353-q2k2krnm	1178	3	al	al	NNP
cord-022353-q2k2krnm	1178	4	.	.	.
cord-022353-q2k2krnm	1179	1	(	(	-LRB-
cord-022353-q2k2krnm	1179	2	1997	1997	CD
cord-022353-q2k2krnm	1179	3	)	)	-RRB-
cord-022353-q2k2krnm	1179	4	engineered	engineer	VBN
cord-022353-q2k2krnm	1179	5	mice	mouse	NNS
cord-022353-q2k2krnm	1179	6	lacking	lack	VBG
cord-022353-q2k2krnm	1179	7	the	the	DT
cord-022353-q2k2krnm	1179	8	PGFzareceptor	pgfzareceptor	NN
cord-022353-q2k2krnm	1179	9	(	(	-LRB-
cord-022353-q2k2krnm	1179	10	FP	FP	NNP
cord-022353-q2k2krnm	1179	11	)	)	-RRB-
cord-022353-q2k2krnm	1179	12	and	and	CC
cord-022353-q2k2krnm	1179	13	found	find	VBD
cord-022353-q2k2krnm	1179	14	that	that	IN
cord-022353-q2k2krnm	1179	15	deficient	deficient	JJ
cord-022353-q2k2krnm	1179	16	female	female	JJ
cord-022353-q2k2krnm	1179	17	mice	mouse	NNS
cord-022353-q2k2krnm	1179	18	had	have	VBD
cord-022353-q2k2krnm	1179	19	normal	normal	JJ
cord-022353-q2k2krnm	1179	20	estrous	estrous	JJ
cord-022353-q2k2krnm	1179	21	cycles	cycle	NNS
cord-022353-q2k2krnm	1179	22	,	,	,
cord-022353-q2k2krnm	1179	23	ovulation	ovulation	NN
cord-022353-q2k2krnm	1179	24	,	,	,
cord-022353-q2k2krnm	1179	25	fertilization	fertilization	NN
cord-022353-q2k2krnm	1179	26	,	,	,
cord-022353-q2k2krnm	1179	27	and	and	CC
cord-022353-q2k2krnm	1179	28	implantation	implantation	NN
cord-022353-q2k2krnm	1179	29	but	but	CC
cord-022353-q2k2krnm	1179	30	did	do	VBD
cord-022353-q2k2krnm	1179	31	not	not	RB
cord-022353-q2k2krnm	1179	32	undergo	undergo	VB
cord-022353-q2k2krnm	1179	33	parturition	parturition	NN
cord-022353-q2k2krnm	1179	34	.	.	.
cord-022353-q2k2krnm	1180	1	These	these	DT
cord-022353-q2k2krnm	1180	2	pregnant	pregnant	JJ
cord-022353-q2k2krnm	1180	3	females	female	NNS
cord-022353-q2k2krnm	1180	4	were	be	VBD
cord-022353-q2k2krnm	1180	5	characterized	characterize	VBN
cord-022353-q2k2krnm	1180	6	by	by	IN
cord-022353-q2k2krnm	1180	7	a	a	DT
cord-022353-q2k2krnm	1180	8	decline	decline	NN
cord-022353-q2k2krnm	1180	9	in	in	IN
cord-022353-q2k2krnm	1180	10	preparturition	preparturition	NN
cord-022353-q2k2krnm	1180	11	progesterone	progesterone	NN
cord-022353-q2k2krnm	1180	12	levels	level	NNS
cord-022353-q2k2krnm	1180	13	due	due	JJ
cord-022353-q2k2krnm	1180	14	to	to	IN
cord-022353-q2k2krnm	1180	15	delayed	delay	VBN
cord-022353-q2k2krnm	1180	16	luteolysis	luteolysis	NN
cord-022353-q2k2krnm	1180	17	and	and	CC
cord-022353-q2k2krnm	1180	18	failure	failure	NN
cord-022353-q2k2krnm	1180	19	to	to	TO
cord-022353-q2k2krnm	1180	20	develop	develop	VB
cord-022353-q2k2krnm	1180	21	labor	labor	NN
cord-022353-q2k2krnm	1180	22	.	.	.
cord-022353-q2k2krnm	1181	1	Close	close	JJ
cord-022353-q2k2krnm	1181	2	examination	examination	NN
cord-022353-q2k2krnm	1181	3	revealed	reveal	VBD
cord-022353-q2k2krnm	1181	4	that	that	IN
cord-022353-q2k2krnm	1181	5	near	near	JJ
cord-022353-q2k2krnm	1181	6	term	term	NN
cord-022353-q2k2krnm	1181	7	there	there	EX
cord-022353-q2k2krnm	1181	8	was	be	VBD
cord-022353-q2k2krnm	1181	9	no	no	DT
cord-022353-q2k2krnm	1181	10	expression	expression	NN
cord-022353-q2k2krnm	1181	11	of	of	IN
cord-022353-q2k2krnm	1181	12	the	the	DT
cord-022353-q2k2krnm	1181	13	oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1181	14	receptor	receptor	NN
cord-022353-q2k2krnm	1181	15	in	in	IN
cord-022353-q2k2krnm	1181	16	the	the	DT
cord-022353-q2k2krnm	1181	17	uterus	uterus	NN
cord-022353-q2k2krnm	1181	18	of	of	IN
cord-022353-q2k2krnm	1181	19	FP	fp	NN
cord-022353-q2k2krnm	1181	20	-	-	HYPH
cord-022353-q2k2krnm	1181	21	deficient	deficient	JJ
cord-022353-q2k2krnm	1181	22	mice	mouse	NNS
cord-022353-q2k2krnm	1181	23	.	.	.
cord-022353-q2k2krnm	1182	1	When	when	WRB
cord-022353-q2k2krnm	1182	2	the	the	DT
cord-022353-q2k2krnm	1182	3	ovaries	ovary	NNS
cord-022353-q2k2krnm	1182	4	of	of	IN
cord-022353-q2k2krnm	1182	5	FP	fp	NN
cord-022353-q2k2krnm	1182	6	-	-	HYPH
cord-022353-q2k2krnm	1182	7	deficient	deficient	JJ
cord-022353-q2k2krnm	1182	8	pregnant	pregnant	JJ
cord-022353-q2k2krnm	1182	9	females	female	NNS
cord-022353-q2k2krnm	1182	10	were	be	VBD
cord-022353-q2k2krnm	1182	11	removed	remove	VBN
cord-022353-q2k2krnm	1182	12	on	on	IN
cord-022353-q2k2krnm	1182	13	day	day	NN
cord-022353-q2k2krnm	1182	14	19	19	CD
cord-022353-q2k2krnm	1182	15	of	of	IN
cord-022353-q2k2krnm	1182	16	pregnancy	pregnancy	NN
cord-022353-q2k2krnm	1182	17	,	,	,
cord-022353-q2k2krnm	1182	18	progesterone	progesterone	NN
cord-022353-q2k2krnm	1182	19	levels	level	NNS
cord-022353-q2k2krnm	1182	20	fell	fall	VBD
cord-022353-q2k2krnm	1182	21	,	,	,
cord-022353-q2k2krnm	1182	22	uterine	uterine	JJ
cord-022353-q2k2krnm	1182	23	oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1182	24	receptors	receptor	NNS
cord-022353-q2k2krnm	1182	25	were	be	VBD
cord-022353-q2k2krnm	1182	26	expressed	express	VBN
cord-022353-q2k2krnm	1182	27	,	,	,
cord-022353-q2k2krnm	1182	28	and	and	CC
cord-022353-q2k2krnm	1182	29	pups	pup	NNS
cord-022353-q2k2krnm	1182	30	were	be	VBD
cord-022353-q2k2krnm	1182	31	born	bear	VBN
cord-022353-q2k2krnm	1182	32	alive	alive	JJ
cord-022353-q2k2krnm	1182	33	within	within	IN
cord-022353-q2k2krnm	1182	34	24	24	CD
cord-022353-q2k2krnm	1182	35	h.	h.	NN
cord-022353-q2k2krnm	1183	1	This	this	DT
cord-022353-q2k2krnm	1183	2	study	study	NN
cord-022353-q2k2krnm	1183	3	demonstrated	demonstrate	VBD
cord-022353-q2k2krnm	1183	4	that	that	IN
cord-022353-q2k2krnm	1183	5	the	the	DT
cord-022353-q2k2krnm	1183	6	role	role	NN
cord-022353-q2k2krnm	1183	7	of	of	IN
cord-022353-q2k2krnm	1183	8	PGF2~	PGF2~	NNP
cord-022353-q2k2krnm	1183	9	is	be	VBZ
cord-022353-q2k2krnm	1183	10	to	to	TO
cord-022353-q2k2krnm	1183	11	initiate	initiate	VB
cord-022353-q2k2krnm	1183	12	luteolysis	luteolysis	NNP
cord-022353-q2k2krnm	1183	13	,	,	,
cord-022353-q2k2krnm	1183	14	resulting	result	VBG
cord-022353-q2k2krnm	1183	15	in	in	IN
cord-022353-q2k2krnm	1183	16	an	an	DT
cord-022353-q2k2krnm	1183	17	immediate	immediate	JJ
cord-022353-q2k2krnm	1183	18	decline	decline	NN
cord-022353-q2k2krnm	1183	19	in	in	IN
cord-022353-q2k2krnm	1183	20	progesterone	progesterone	NN
cord-022353-q2k2krnm	1183	21	levels	level	NNS
cord-022353-q2k2krnm	1183	22	.	.	.
cord-022353-q2k2krnm	1184	1	The	the	DT
cord-022353-q2k2krnm	1184	2	subsequent	subsequent	JJ
cord-022353-q2k2krnm	1184	3	induction	induction	NN
cord-022353-q2k2krnm	1184	4	of	of	IN
cord-022353-q2k2krnm	1184	5	oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1184	6	receptors	receptor	NNS
cord-022353-q2k2krnm	1184	7	and	and	CC
cord-022353-q2k2krnm	1184	8	their	-PRON-	PRP$
cord-022353-q2k2krnm	1184	9	activation	activation	NN
cord-022353-q2k2krnm	1184	10	by	by	IN
cord-022353-q2k2krnm	1184	11	bound	bind	VBN
cord-022353-q2k2krnm	1184	12	oxytocin	oxytocin	NNS
cord-022353-q2k2krnm	1184	13	initiate	initiate	VBP
cord-022353-q2k2krnm	1184	14	labor	labor	NN
cord-022353-q2k2krnm	1184	15	.	.	.
cord-022353-q2k2krnm	1185	1	It	-PRON-	PRP
cord-022353-q2k2krnm	1185	2	is	be	VBZ
cord-022353-q2k2krnm	1185	3	feasible	feasible	JJ
cord-022353-q2k2krnm	1185	4	that	that	IN
cord-022353-q2k2krnm	1185	5	the	the	DT
cord-022353-q2k2krnm	1185	6	age	age	NN
cord-022353-q2k2krnm	1185	7	-	-	HYPH
cord-022353-q2k2krnm	1185	8	associated	associate	VBN
cord-022353-q2k2krnm	1185	9	prolongation	prolongation	NN
cord-022353-q2k2krnm	1185	10	of	of	IN
cord-022353-q2k2krnm	1185	11	gestation	gestation	NN
cord-022353-q2k2krnm	1185	12	in	in	IN
cord-022353-q2k2krnm	1185	13	old	old	JJ
cord-022353-q2k2krnm	1185	14	female	female	JJ
cord-022353-q2k2krnm	1185	15	mice	mouse	NNS
cord-022353-q2k2krnm	1185	16	may	may	MD
cord-022353-q2k2krnm	1185	17	involve	involve	VB
cord-022353-q2k2krnm	1185	18	a	a	DT
cord-022353-q2k2krnm	1185	19	defect	defect	NN
cord-022353-q2k2krnm	1185	20	in	in	IN
cord-022353-q2k2krnm	1185	21	PGFz,~-induced	pgfz,~-induce	VBN
cord-022353-q2k2krnm	1185	22	luteolysis	luteolysis	NN
cord-022353-q2k2krnm	1185	23	.	.	.
cord-022353-q2k2krnm	1186	1	This	this	DT
cord-022353-q2k2krnm	1186	2	mechanism	mechanism	NN
cord-022353-q2k2krnm	1186	3	for	for	IN
cord-022353-q2k2krnm	1186	4	the	the	DT
cord-022353-q2k2krnm	1186	5	induction	induction	NN
cord-022353-q2k2krnm	1186	6	of	of	IN
cord-022353-q2k2krnm	1186	7	labor	labor	NN
cord-022353-q2k2krnm	1186	8	also	also	RB
cord-022353-q2k2krnm	1186	9	explains	explain	VBZ
cord-022353-q2k2krnm	1186	10	the	the	DT
cord-022353-q2k2krnm	1186	11	well	well	RB
cord-022353-q2k2krnm	1186	12	-	-	HYPH
cord-022353-q2k2krnm	1186	13	known	know	VBN
cord-022353-q2k2krnm	1186	14	observation	observation	NN
cord-022353-q2k2krnm	1186	15	that	that	IN
cord-022353-q2k2krnm	1186	16	aspirin	aspirin	NN
cord-022353-q2k2krnm	1186	17	-	-	HYPH
cord-022353-q2k2krnm	1186	18	like	like	JJ
cord-022353-q2k2krnm	1186	19	drugs	drug	NNS
cord-022353-q2k2krnm	1186	20	(	(	-LRB-
cord-022353-q2k2krnm	1186	21	that	that	WDT
cord-022353-q2k2krnm	1186	22	inhibit	inhibit	VBP
cord-022353-q2k2krnm	1186	23	COX	COX	NNP
cord-022353-q2k2krnm	1186	24	metabolism	metabolism	NN
cord-022353-q2k2krnm	1186	25	)	)	-RRB-
cord-022353-q2k2krnm	1186	26	may	may	MD
cord-022353-q2k2krnm	1186	27	delay	delay	VB
cord-022353-q2k2krnm	1186	28	parturition	parturition	NN
cord-022353-q2k2krnm	1186	29	in	in	IN
cord-022353-q2k2krnm	1186	30	women	woman	NNS
cord-022353-q2k2krnm	1186	31	.	.	.
cord-022353-q2k2krnm	1187	1	PRL	PRL	NNP
cord-022353-q2k2krnm	1187	2	,	,	,
cord-022353-q2k2krnm	1187	3	a	a	DT
cord-022353-q2k2krnm	1187	4	23-kDa	23-kda	CD
cord-022353-q2k2krnm	1187	5	single	single	JJ
cord-022353-q2k2krnm	1187	6	-	-	HYPH
cord-022353-q2k2krnm	1187	7	chain	chain	NN
cord-022353-q2k2krnm	1187	8	polypeptide	polypeptide	NN
cord-022353-q2k2krnm	1187	9	,	,	,
cord-022353-q2k2krnm	1187	10	is	be	VBZ
cord-022353-q2k2krnm	1187	11	principally	principally	RB
cord-022353-q2k2krnm	1187	12	made	make	VBN
cord-022353-q2k2krnm	1187	13	by	by	IN
cord-022353-q2k2krnm	1187	14	the	the	DT
cord-022353-q2k2krnm	1187	15	pituitary	pituitary	JJ
cord-022353-q2k2krnm	1187	16	gland	gland	NN
cord-022353-q2k2krnm	1187	17	but	but	CC
cord-022353-q2k2krnm	1187	18	may	may	MD
cord-022353-q2k2krnm	1187	19	be	be	VB
cord-022353-q2k2krnm	1187	20	also	also	RB
cord-022353-q2k2krnm	1187	21	be	be	VB
cord-022353-q2k2krnm	1187	22	found	find	VBN
cord-022353-q2k2krnm	1187	23	in	in	IN
cord-022353-q2k2krnm	1187	24	brain	brain	NN
cord-022353-q2k2krnm	1187	25	,	,	,
cord-022353-q2k2krnm	1187	26	thymus	thymus	NN
cord-022353-q2k2krnm	1187	27	,	,	,
cord-022353-q2k2krnm	1187	28	spleen	spleen	NNS
cord-022353-q2k2krnm	1187	29	,	,	,
cord-022353-q2k2krnm	1187	30	lymph	lymph	NN
cord-022353-q2k2krnm	1187	31	nodes	node	NNS
cord-022353-q2k2krnm	1187	32	,	,	,
cord-022353-q2k2krnm	1187	33	mammary	mammary	JJ
cord-022353-q2k2krnm	1187	34	gland	gland	NN
cord-022353-q2k2krnm	1187	35	,	,	,
cord-022353-q2k2krnm	1187	36	myometrium	myometrium	NN
cord-022353-q2k2krnm	1187	37	,	,	,
cord-022353-q2k2krnm	1187	38	sweat	sweat	NN
cord-022353-q2k2krnm	1187	39	gland	gland	NN
cord-022353-q2k2krnm	1187	40	,	,	,
cord-022353-q2k2krnm	1187	41	lacrimal	lacrimal	JJ
cord-022353-q2k2krnm	1187	42	gland	gland	NN
cord-022353-q2k2krnm	1187	43	,	,	,
cord-022353-q2k2krnm	1187	44	and	and	CC
cord-022353-q2k2krnm	1187	45	bone	bone	NN
cord-022353-q2k2krnm	1187	46	marrow	marrow	NN
cord-022353-q2k2krnm	1187	47	.	.	.
cord-022353-q2k2krnm	1188	1	More	More	JJR
cord-022353-q2k2krnm	1188	2	than	than	IN
cord-022353-q2k2krnm	1188	3	300	300	CD
cord-022353-q2k2krnm	1188	4	functions	function	NNS
cord-022353-q2k2krnm	1188	5	have	have	VBP
cord-022353-q2k2krnm	1188	6	been	be	VBN
cord-022353-q2k2krnm	1188	7	attributed	attribute	VBN
cord-022353-q2k2krnm	1188	8	to	to	IN
cord-022353-q2k2krnm	1188	9	PRL	PRL	NNP
cord-022353-q2k2krnm	1188	10	,	,	,
cord-022353-q2k2krnm	1188	11	involving	involve	VBG
cord-022353-q2k2krnm	1188	12	reproduction	reproduction	NN
cord-022353-q2k2krnm	1188	13	and	and	CC
cord-022353-q2k2krnm	1188	14	lactation	lactation	NN
cord-022353-q2k2krnm	1188	15	,	,	,
cord-022353-q2k2krnm	1188	16	growth	growth	NN
cord-022353-q2k2krnm	1188	17	and	and	CC
cord-022353-q2k2krnm	1188	18	development	development	NN
cord-022353-q2k2krnm	1188	19	,	,	,
cord-022353-q2k2krnm	1188	20	endocrinology	endocrinology	NN
cord-022353-q2k2krnm	1188	21	and	and	CC
cord-022353-q2k2krnm	1188	22	metabolism	metabolism	NN
cord-022353-q2k2krnm	1188	23	,	,	,
cord-022353-q2k2krnm	1188	24	brain	brain	NN
cord-022353-q2k2krnm	1188	25	and	and	CC
cord-022353-q2k2krnm	1188	26	behavior	behavior	NN
cord-022353-q2k2krnm	1188	27	,	,	,
cord-022353-q2k2krnm	1188	28	immunomodulation	immunomodulation	NN
cord-022353-q2k2krnm	1188	29	,	,	,
cord-022353-q2k2krnm	1188	30	and	and	CC
cord-022353-q2k2krnm	1188	31	electrolyte	electrolyte	JJ
cord-022353-q2k2krnm	1188	32	balance	balance	NN
cord-022353-q2k2krnm	1188	33	.	.	.
cord-022353-q2k2krnm	1189	1	It	-PRON-	PRP
cord-022353-q2k2krnm	1189	2	mediates	mediate	VBZ
cord-022353-q2k2krnm	1189	3	effects	effect	NNS
cord-022353-q2k2krnm	1189	4	by	by	IN
cord-022353-q2k2krnm	1189	5	endocrine	endocrine	NN
cord-022353-q2k2krnm	1189	6	,	,	,
cord-022353-q2k2krnm	1189	7	paracrine	paracrine	NN
cord-022353-q2k2krnm	1189	8	,	,	,
cord-022353-q2k2krnm	1189	9	and	and	CC
cord-022353-q2k2krnm	1189	10	autocrine	autocrine	NN
cord-022353-q2k2krnm	1189	11	mechanisms	mechanism	NNS
cord-022353-q2k2krnm	1189	12	.	.	.
cord-022353-q2k2krnm	1190	1	In	in	IN
cord-022353-q2k2krnm	1190	2	mice	mouse	NNS
cord-022353-q2k2krnm	1190	3	,	,	,
cord-022353-q2k2krnm	1190	4	PRL	PRL	NNP
cord-022353-q2k2krnm	1190	5	is	be	VBZ
cord-022353-q2k2krnm	1190	6	of	of	IN
cord-022353-q2k2krnm	1190	7	major	major	JJ
cord-022353-q2k2krnm	1190	8	importance	importance	NN
cord-022353-q2k2krnm	1190	9	for	for	IN
cord-022353-q2k2krnm	1190	10	maintenance	maintenance	NN
cord-022353-q2k2krnm	1190	11	of	of	IN
cord-022353-q2k2krnm	1190	12	the	the	DT
cord-022353-q2k2krnm	1190	13	structure	structure	NN
cord-022353-q2k2krnm	1190	14	,	,	,
cord-022353-q2k2krnm	1190	15	life	life	NN
cord-022353-q2k2krnm	1190	16	span	span	NN
cord-022353-q2k2krnm	1190	17	,	,	,
cord-022353-q2k2krnm	1190	18	and	and	CC
cord-022353-q2k2krnm	1190	19	function	function	NN
cord-022353-q2k2krnm	1190	20	of	of	IN
cord-022353-q2k2krnm	1190	21	the	the	DT
cord-022353-q2k2krnm	1190	22	corpora	corpora	NN
cord-022353-q2k2krnm	1190	23	lutea	lutea	NN
cord-022353-q2k2krnm	1190	24	and	and	CC
cord-022353-q2k2krnm	1190	25	the	the	DT
cord-022353-q2k2krnm	1190	26	development	development	NN
cord-022353-q2k2krnm	1190	27	and	and	CC
cord-022353-q2k2krnm	1190	28	maintenance	maintenance	NN
cord-022353-q2k2krnm	1190	29	of	of	IN
cord-022353-q2k2krnm	1190	30	the	the	DT
cord-022353-q2k2krnm	1190	31	mammary	mammary	JJ
cord-022353-q2k2krnm	1190	32	gland	gland	NN
cord-022353-q2k2krnm	1190	33	and	and	CC
cord-022353-q2k2krnm	1190	34	lactation	lactation	NN
cord-022353-q2k2krnm	1190	35	.	.	.
cord-022353-q2k2krnm	1191	1	However	however	RB
cord-022353-q2k2krnm	1191	2	,	,	,
cord-022353-q2k2krnm	1191	3	PRL	PRL	NNP
cord-022353-q2k2krnm	1191	4	-	-	HYPH
cord-022353-q2k2krnm	1191	5	receptor	receptor	NN
cord-022353-q2k2krnm	1191	6	KO	KO	NNP
cord-022353-q2k2krnm	1191	7	males	male	NNS
cord-022353-q2k2krnm	1191	8	have	have	VBP
cord-022353-q2k2krnm	1191	9	no	no	DT
cord-022353-q2k2krnm	1191	10	major	major	JJ
cord-022353-q2k2krnm	1191	11	defect	defect	NN
cord-022353-q2k2krnm	1191	12	in	in	IN
cord-022353-q2k2krnm	1191	13	fertility	fertility	NN
cord-022353-q2k2krnm	1191	14	.	.	.
cord-022353-q2k2krnm	1192	1	PRL	PRL	NNP
cord-022353-q2k2krnm	1192	2	plays	play	VBZ
cord-022353-q2k2krnm	1192	3	a	a	DT
cord-022353-q2k2krnm	1192	4	role	role	NN
cord-022353-q2k2krnm	1192	5	in	in	IN
cord-022353-q2k2krnm	1192	6	anxiety	anxiety	NN
cord-022353-q2k2krnm	1192	7	-	-	HYPH
cord-022353-q2k2krnm	1192	8	related	relate	VBN
cord-022353-q2k2krnm	1192	9	behaviors	behavior	NNS
cord-022353-q2k2krnm	1192	10	,	,	,
cord-022353-q2k2krnm	1192	11	bone	bone	NN
cord-022353-q2k2krnm	1192	12	development	development	NN
cord-022353-q2k2krnm	1192	13	,	,	,
cord-022353-q2k2krnm	1192	14	and	and	CC
cord-022353-q2k2krnm	1192	15	abdominal	abdominal	JJ
cord-022353-q2k2krnm	1192	16	fat	fat	JJ
cord-022353-q2k2krnm	1192	17	deposition	deposition	NN
cord-022353-q2k2krnm	1192	18	in	in	IN
cord-022353-q2k2krnm	1192	19	both	both	DT
cord-022353-q2k2krnm	1192	20	sexes	sex	NNS
cord-022353-q2k2krnm	1193	1	(	(	-LRB-
cord-022353-q2k2krnm	1193	2	Kelly	Kelly	NNP
cord-022353-q2k2krnm	1193	3	et	et	NNP
cord-022353-q2k2krnm	1193	4	al	al	NNP
cord-022353-q2k2krnm	1193	5	.	.	NNP
cord-022353-q2k2krnm	1193	6	2001	2001	CD
cord-022353-q2k2krnm	1193	7	)	)	-RRB-
cord-022353-q2k2krnm	1193	8	.	.	.
cord-022353-q2k2krnm	1194	1	Its	-PRON-	PRP$
cord-022353-q2k2krnm	1194	2	role	role	NN
cord-022353-q2k2krnm	1194	3	in	in	IN
cord-022353-q2k2krnm	1194	4	immune	immune	JJ
cord-022353-q2k2krnm	1194	5	function	function	NN
cord-022353-q2k2krnm	1194	6	is	be	VBZ
cord-022353-q2k2krnm	1194	7	more	more	RBR
cord-022353-q2k2krnm	1194	8	controversial	controversial	JJ
cord-022353-q2k2krnm	1194	9	,	,	,
cord-022353-q2k2krnm	1194	10	although	although	IN
cord-022353-q2k2krnm	1194	11	it	-PRON-	PRP
cord-022353-q2k2krnm	1194	12	appears	appear	VBZ
cord-022353-q2k2krnm	1194	13	to	to	TO
cord-022353-q2k2krnm	1194	14	modulate	modulate	VB
cord-022353-q2k2krnm	1194	15	immunity	immunity	NN
cord-022353-q2k2krnm	1194	16	during	during	IN
cord-022353-q2k2krnm	1194	17	times	time	NNS
cord-022353-q2k2krnm	1194	18	of	of	IN
cord-022353-q2k2krnm	1194	19	stress	stress	NN
cord-022353-q2k2krnm	1194	20	(	(	-LRB-
cord-022353-q2k2krnm	1194	21	Dorshkind	Dorshkind	NNP
cord-022353-q2k2krnm	1194	22	and	and	CC
cord-022353-q2k2krnm	1194	23	Horseman	Horseman	NNP
cord-022353-q2k2krnm	1194	24	2000	2000	CD
cord-022353-q2k2krnm	1194	25	)	)	-RRB-
cord-022353-q2k2krnm	1194	26	.	.	.
cord-022353-q2k2krnm	1195	1	PRL	PRL	NNP
cord-022353-q2k2krnm	1195	2	mediates	mediate	VBZ
cord-022353-q2k2krnm	1195	3	its	-PRON-	PRP$
cord-022353-q2k2krnm	1195	4	effects	effect	NNS
cord-022353-q2k2krnm	1195	5	by	by	IN
cord-022353-q2k2krnm	1195	6	binding	bind	VBG
cord-022353-q2k2krnm	1195	7	the	the	DT
cord-022353-q2k2krnm	1195	8	PRL	PRL	NNP
cord-022353-q2k2krnm	1195	9	receptor	receptor	NN
cord-022353-q2k2krnm	1195	10	(	(	-LRB-
cord-022353-q2k2krnm	1195	11	PRLR	PRLR	NNP
cord-022353-q2k2krnm	1195	12	)	)	-RRB-
cord-022353-q2k2krnm	1195	13	.	.	.
cord-022353-q2k2krnm	1196	1	Mice	mouse	NNS
cord-022353-q2k2krnm	1196	2	have	have	VBP
cord-022353-q2k2krnm	1196	3	two	two	CD
cord-022353-q2k2krnm	1196	4	major	major	JJ
cord-022353-q2k2krnm	1196	5	forms	form	NNS
cord-022353-q2k2krnm	1196	6	of	of	IN
cord-022353-q2k2krnm	1196	7	PRLR	PRLR	NNP
cord-022353-q2k2krnm	1196	8	that	that	WDT
cord-022353-q2k2krnm	1196	9	are	be	VBP
cord-022353-q2k2krnm	1196	10	created	create	VBN
cord-022353-q2k2krnm	1196	11	via	via	IN
cord-022353-q2k2krnm	1196	12	alternative	alternative	JJ
cord-022353-q2k2krnm	1196	13	splicing	splicing	NN
cord-022353-q2k2krnm	1196	14	of	of	IN
cord-022353-q2k2krnm	1196	15	a	a	DT
cord-022353-q2k2krnm	1196	16	single	single	JJ
cord-022353-q2k2krnm	1196	17	gene	gene	NN
cord-022353-q2k2krnm	1196	18	.	.	.
cord-022353-q2k2krnm	1197	1	The	the	DT
cord-022353-q2k2krnm	1197	2	PRLRs	prlr	NNS
cord-022353-q2k2krnm	1197	3	are	be	VBP
cord-022353-q2k2krnm	1197	4	members	member	NNS
cord-022353-q2k2krnm	1197	5	of	of	IN
cord-022353-q2k2krnm	1197	6	the	the	DT
cord-022353-q2k2krnm	1197	7	class	class	NN
cord-022353-q2k2krnm	1198	1	I	-PRON-	PRP
cord-022353-q2k2krnm	1198	2	cytokine	cytokine	NN
cord-022353-q2k2krnm	1198	3	receptor	receptor	NN
cord-022353-q2k2krnm	1198	4	superfamily	superfamily	NN
cord-022353-q2k2krnm	1198	5	.	.	.
cord-022353-q2k2krnm	1199	1	Although	although	IN
cord-022353-q2k2krnm	1199	2	most	most	JJS
cord-022353-q2k2krnm	1199	3	functions	function	NNS
cord-022353-q2k2krnm	1199	4	of	of	IN
cord-022353-q2k2krnm	1199	5	PRL	PRL	NNP
cord-022353-q2k2krnm	1199	6	are	be	VBP
cord-022353-q2k2krnm	1199	7	mediated	mediate	VBN
cord-022353-q2k2krnm	1199	8	by	by	IN
cord-022353-q2k2krnm	1199	9	the	the	DT
cord-022353-q2k2krnm	1199	10	unmodified	unmodified	JJ
cord-022353-q2k2krnm	1199	11	23-kDa	23-kda	CD
cord-022353-q2k2krnm	1199	12	peptide	peptide	NN
cord-022353-q2k2krnm	1199	13	,	,	,
cord-022353-q2k2krnm	1199	14	post	post	JJ
cord-022353-q2k2krnm	1199	15	-	-	JJ
cord-022353-q2k2krnm	1199	16	translational	translational	JJ
cord-022353-q2k2krnm	1199	17	modification	modification	NN
cord-022353-q2k2krnm	1199	18	allows	allow	VBZ
cord-022353-q2k2krnm	1199	19	variants	variant	NNS
cord-022353-q2k2krnm	1199	20	of	of	IN
cord-022353-q2k2krnm	1199	21	PRL	PRL	NNP
cord-022353-q2k2krnm	1199	22	to	to	TO
cord-022353-q2k2krnm	1199	23	bind	bind	VB
cord-022353-q2k2krnm	1199	24	its	-PRON-	PRP$
cord-022353-q2k2krnm	1199	25	receptor	receptor	NN
cord-022353-q2k2krnm	1199	26	eliciting	elicit	VBG
cord-022353-q2k2krnm	1199	27	transcription	transcription	NN
cord-022353-q2k2krnm	1199	28	of	of	IN
cord-022353-q2k2krnm	1199	29	genes	gene	NNS
cord-022353-q2k2krnm	1199	30	necessary	necessary	JJ
cord-022353-q2k2krnm	1199	31	for	for	IN
cord-022353-q2k2krnm	1199	32	tissue	tissue	NN
cord-022353-q2k2krnm	1199	33	specific	specific	JJ
cord-022353-q2k2krnm	1199	34	changes	change	NNS
cord-022353-q2k2krnm	1199	35	(	(	-LRB-
cord-022353-q2k2krnm	1199	36	Harris	Harris	NNP
cord-022353-q2k2krnm	1199	37	et	et	NNP
cord-022353-q2k2krnm	1199	38	al	al	NNP
cord-022353-q2k2krnm	1199	39	.	.	.
cord-022353-q2k2krnm	1199	40	2004	2004	CD
cord-022353-q2k2krnm	1199	41	)	)	-RRB-
cord-022353-q2k2krnm	1199	42	.	.	.
cord-022353-q2k2krnm	1200	1	PRL	prl	JJ
cord-022353-q2k2krnm	1200	2	secretion	secretion	NN
cord-022353-q2k2krnm	1200	3	is	be	VBZ
cord-022353-q2k2krnm	1200	4	under	under	IN
cord-022353-q2k2krnm	1200	5	inhibitory	inhibitory	JJ
cord-022353-q2k2krnm	1200	6	control	control	NN
cord-022353-q2k2krnm	1200	7	by	by	IN
cord-022353-q2k2krnm	1200	8	dopamine	dopamine	NN
cord-022353-q2k2krnm	1200	9	and	and	CC
cord-022353-q2k2krnm	1200	10	among	among	IN
cord-022353-q2k2krnm	1200	11	its	-PRON-	PRP$
cord-022353-q2k2krnm	1200	12	secretagogues	secretagogue	NNS
cord-022353-q2k2krnm	1200	13	are	be	VBP
cord-022353-q2k2krnm	1200	14	thyrotropin	thyrotropin	RB
cord-022353-q2k2krnm	1200	15	-	-	HYPH
cord-022353-q2k2krnm	1200	16	releasing	release	VBG
cord-022353-q2k2krnm	1200	17	hormone	hormone	NN
cord-022353-q2k2krnm	1200	18	(	(	-LRB-
cord-022353-q2k2krnm	1200	19	TRH	TRH	NNP
cord-022353-q2k2krnm	1200	20	)	)	-RRB-
cord-022353-q2k2krnm	1200	21	,	,	,
cord-022353-q2k2krnm	1200	22	vasoactive	vasoactive	JJ
cord-022353-q2k2krnm	1200	23	intestinal	intestinal	JJ
cord-022353-q2k2krnm	1200	24	peptide	peptide	NN
cord-022353-q2k2krnm	1200	25	,	,	,
cord-022353-q2k2krnm	1200	26	gastrin	gastrin	NN
cord-022353-q2k2krnm	1200	27	,	,	,
cord-022353-q2k2krnm	1200	28	serotonin	serotonin	NN
cord-022353-q2k2krnm	1200	29	,	,	,
cord-022353-q2k2krnm	1200	30	~-endorphin	~-endorphin	NFP
cord-022353-q2k2krnm	1200	31	,	,	,
cord-022353-q2k2krnm	1200	32	oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1200	33	,	,	,
cord-022353-q2k2krnm	1200	34	angiotensin	angiotensin	NN
cord-022353-q2k2krnm	1200	35	II	II	NNP
cord-022353-q2k2krnm	1200	36	,	,	,
cord-022353-q2k2krnm	1200	37	GnRH	GnRH	NNP
cord-022353-q2k2krnm	1200	38	,	,	,
cord-022353-q2k2krnm	1200	39	and	and	CC
cord-022353-q2k2krnm	1200	40	arginine	arginine	NN
cord-022353-q2k2krnm	1200	41	vasopressin	vasopressin	NN
cord-022353-q2k2krnm	1200	42	.	.	.
cord-022353-q2k2krnm	1201	1	PRL	prl	NN
cord-022353-q2k2krnm	1201	2	in	in	IN
cord-022353-q2k2krnm	1201	3	mice	mice	NN
cord-022353-q2k2krnm	1201	4	is	be	VBZ
cord-022353-q2k2krnm	1201	5	quantified	quantify	VBN
cord-022353-q2k2krnm	1201	6	using	use	VBG
cord-022353-q2k2krnm	1201	7	RIA	RIA	NNP
cord-022353-q2k2krnm	1201	8	using	use	VBG
cord-022353-q2k2krnm	1201	9	the	the	DT
cord-022353-q2k2krnm	1201	10	NIH	NIH	NNP
cord-022353-q2k2krnm	1201	11	RP-1	RP-1	NNP
cord-022353-q2k2krnm	1201	12	reference	reference	NN
cord-022353-q2k2krnm	1201	13	standard	standard	NN
cord-022353-q2k2krnm	1201	14	.	.	.
cord-022353-q2k2krnm	1202	1	Male	male	JJ
cord-022353-q2k2krnm	1202	2	mice	mouse	NNS
cord-022353-q2k2krnm	1202	3	measured	measure	VBN
cord-022353-q2k2krnm	1202	4	during	during	IN
cord-022353-q2k2krnm	1202	5	the	the	DT
cord-022353-q2k2krnm	1202	6	light	light	JJ
cord-022353-q2k2krnm	1202	7	phase	phase	NN
cord-022353-q2k2krnm	1202	8	have	have	VBP
cord-022353-q2k2krnm	1202	9	<	<	XX
cord-022353-q2k2krnm	1202	10	1	1	CD
cord-022353-q2k2krnm	1202	11	ng	ng	NNP
cord-022353-q2k2krnm	1202	12	/	/	SYM
cord-022353-q2k2krnm	1202	13	ml	ml	XX
cord-022353-q2k2krnm	1202	14	whereas	whereas	IN
cord-022353-q2k2krnm	1202	15	the	the	DT
cord-022353-q2k2krnm	1202	16	range	range	NN
cord-022353-q2k2krnm	1202	17	during	during	IN
cord-022353-q2k2krnm	1202	18	the	the	DT
cord-022353-q2k2krnm	1202	19	dark	dark	JJ
cord-022353-q2k2krnm	1202	20	phase	phase	NN
cord-022353-q2k2krnm	1202	21	was	be	VBD
cord-022353-q2k2krnm	1202	22	10	10	CD
cord-022353-q2k2krnm	1202	23	-	-	SYM
cord-022353-q2k2krnm	1202	24	20	20	CD
cord-022353-q2k2krnm	1202	25	ng	ng	NN
cord-022353-q2k2krnm	1202	26	/	/	SYM
cord-022353-q2k2krnm	1202	27	ml	ml	NNP
cord-022353-q2k2krnm	1202	28	(	(	-LRB-
cord-022353-q2k2krnm	1202	29	DePaolo	DePaolo	NNP
cord-022353-q2k2krnm	1202	30	and	and	CC
cord-022353-q2k2krnm	1202	31	Masoro	Masoro	NNP
cord-022353-q2k2krnm	1202	32	989	989	CD
cord-022353-q2k2krnm	1202	33	)	)	-RRB-
cord-022353-q2k2krnm	1202	34	.	.	.
cord-022353-q2k2krnm	1203	1	Oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1203	2	,	,	,
cord-022353-q2k2krnm	1203	3	a	a	DT
cord-022353-q2k2krnm	1203	4	21-kDa	21-kda	CD
cord-022353-q2k2krnm	1203	5	nonapeptide	nonapeptide	NN
cord-022353-q2k2krnm	1203	6	,	,	,
cord-022353-q2k2krnm	1203	7	is	be	VBZ
cord-022353-q2k2krnm	1203	8	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1203	9	as	as	IN
cord-022353-q2k2krnm	1203	10	a	a	DT
cord-022353-q2k2krnm	1203	11	prohormone	prohormone	NN
cord-022353-q2k2krnm	1203	12	in	in	IN
cord-022353-q2k2krnm	1203	13	neurons	neuron	NNS
cord-022353-q2k2krnm	1203	14	whose	whose	WP$
cord-022353-q2k2krnm	1203	15	bodies	body	NNS
cord-022353-q2k2krnm	1203	16	are	be	VBP
cord-022353-q2k2krnm	1203	17	located	locate	VBN
cord-022353-q2k2krnm	1203	18	in	in	IN
cord-022353-q2k2krnm	1203	19	the	the	DT
cord-022353-q2k2krnm	1203	20	supraoptic	supraoptic	JJ
cord-022353-q2k2krnm	1203	21	and	and	CC
cord-022353-q2k2krnm	1203	22	paraventricular	paraventricular	JJ
cord-022353-q2k2krnm	1203	23	nuclei	nucleus	NNS
cord-022353-q2k2krnm	1203	24	at	at	IN
cord-022353-q2k2krnm	1203	25	the	the	DT
cord-022353-q2k2krnm	1203	26	base	base	NN
cord-022353-q2k2krnm	1203	27	of	of	IN
cord-022353-q2k2krnm	1203	28	the	the	DT
cord-022353-q2k2krnm	1203	29	hypothalamus	hypothalamus	NN
cord-022353-q2k2krnm	1203	30	.	.	.
cord-022353-q2k2krnm	1204	1	Once	once	RB
cord-022353-q2k2krnm	1204	2	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1204	3	,	,	,
cord-022353-q2k2krnm	1204	4	the	the	DT
cord-022353-q2k2krnm	1204	5	prohormone	prohormone	NN
cord-022353-q2k2krnm	1204	6	is	be	VBZ
cord-022353-q2k2krnm	1204	7	packaged	package	VBN
cord-022353-q2k2krnm	1204	8	into	into	IN
cord-022353-q2k2krnm	1204	9	neurosecretory	neurosecretory	NN
cord-022353-q2k2krnm	1204	10	granules	granule	NNS
cord-022353-q2k2krnm	1204	11	and	and	CC
cord-022353-q2k2krnm	1204	12	transported	transport	VBD
cord-022353-q2k2krnm	1204	13	down	down	RP
cord-022353-q2k2krnm	1204	14	the	the	DT
cord-022353-q2k2krnm	1204	15	axons	axon	NNS
cord-022353-q2k2krnm	1204	16	of	of	IN
cord-022353-q2k2krnm	1204	17	these	these	DT
cord-022353-q2k2krnm	1204	18	neurons	neuron	NNS
cord-022353-q2k2krnm	1204	19	transport	transport	NN
cord-022353-q2k2krnm	1204	20	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1204	21	oxytocin	oxytocin	NNS
cord-022353-q2k2krnm	1204	22	to	to	IN
cord-022353-q2k2krnm	1204	23	the	the	DT
cord-022353-q2k2krnm	1204	24	pars	par	NNS
cord-022353-q2k2krnm	1204	25	nervosa	nervosa	RB
cord-022353-q2k2krnm	1204	26	of	of	IN
cord-022353-q2k2krnm	1204	27	the	the	DT
cord-022353-q2k2krnm	1204	28	pituitary	pituitary	JJ
cord-022353-q2k2krnm	1204	29	gland	gland	NN
cord-022353-q2k2krnm	1204	30	.	.	.
cord-022353-q2k2krnm	1205	1	During	during	IN
cord-022353-q2k2krnm	1205	2	transport	transport	NN
cord-022353-q2k2krnm	1205	3	,	,	,
cord-022353-q2k2krnm	1205	4	the	the	DT
cord-022353-q2k2krnm	1205	5	molecule	molecule	NN
cord-022353-q2k2krnm	1205	6	is	be	VBZ
cord-022353-q2k2krnm	1205	7	cleaved	cleave	VBN
cord-022353-q2k2krnm	1205	8	to	to	TO
cord-022353-q2k2krnm	1205	9	yield	yield	VB
cord-022353-q2k2krnm	1205	10	the	the	DT
cord-022353-q2k2krnm	1205	11	10-kDa	10-kda	CD
cord-022353-q2k2krnm	1205	12	carrier	carrier	NN
cord-022353-q2k2krnm	1205	13	proteins	protein	NNS
cord-022353-q2k2krnm	1205	14	,	,	,
cord-022353-q2k2krnm	1205	15	neurophysin	neurophysin	NNP
cord-022353-q2k2krnm	1205	16	I	-PRON-	PRP
cord-022353-q2k2krnm	1205	17	,	,	,
cord-022353-q2k2krnm	1205	18	and	and	CC
cord-022353-q2k2krnm	1205	19	the	the	DT
cord-022353-q2k2krnm	1205	20	l	l	NNP
cord-022353-q2k2krnm	1205	21	l	l	NNP
cord-022353-q2k2krnm	1205	22	-	-	HYPH
cord-022353-q2k2krnm	1205	23	kDa	kDa	NNP
cord-022353-q2k2krnm	1205	24	oxytocin	oxytocin	NNS
cord-022353-q2k2krnm	1205	25	.	.	.
cord-022353-q2k2krnm	1206	1	The	the	DT
cord-022353-q2k2krnm	1206	2	primary	primary	JJ
cord-022353-q2k2krnm	1206	3	stimulus	stimulus	NN
cord-022353-q2k2krnm	1206	4	for	for	IN
cord-022353-q2k2krnm	1206	5	oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1206	6	release	release	NN
cord-022353-q2k2krnm	1206	7	is	be	VBZ
cord-022353-q2k2krnm	1206	8	mechanical	mechanical	JJ
cord-022353-q2k2krnm	1206	9	stimulation	stimulation	NN
cord-022353-q2k2krnm	1206	10	of	of	IN
cord-022353-q2k2krnm	1206	11	the	the	DT
cord-022353-q2k2krnm	1206	12	mammary	mammary	JJ
cord-022353-q2k2krnm	1206	13	gland	gland	NN
cord-022353-q2k2krnm	1206	14	and	and	CC
cord-022353-q2k2krnm	1206	15	distention	distention	NN
cord-022353-q2k2krnm	1206	16	of	of	IN
cord-022353-q2k2krnm	1206	17	the	the	DT
cord-022353-q2k2krnm	1206	18	reproductive	reproductive	JJ
cord-022353-q2k2krnm	1206	19	tract	tract	NN
cord-022353-q2k2krnm	1206	20	(	(	-LRB-
cord-022353-q2k2krnm	1206	21	Reimers	Reimers	NNPS
cord-022353-q2k2krnm	1206	22	1999	1999	CD
cord-022353-q2k2krnm	1206	23	)	)	-RRB-
cord-022353-q2k2krnm	1206	24	.	.	.
cord-022353-q2k2krnm	1207	1	There	there	EX
cord-022353-q2k2krnm	1207	2	is	be	VBZ
cord-022353-q2k2krnm	1207	3	a	a	DT
cord-022353-q2k2krnm	1207	4	single	single	JJ
cord-022353-q2k2krnm	1207	5	oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1207	6	receptor	receptor	NN
cord-022353-q2k2krnm	1207	7	(	(	-LRB-
cord-022353-q2k2krnm	1207	8	OTR	OTR	NNP
cord-022353-q2k2krnm	1207	9	)	)	-RRB-
cord-022353-q2k2krnm	1207	10	.	.	.
cord-022353-q2k2krnm	1208	1	Investigations	investigation	NNS
cord-022353-q2k2krnm	1208	2	using	use	VBG
cord-022353-q2k2krnm	1208	3	KO	KO	NNP
cord-022353-q2k2krnm	1208	4	mice	mouse	NNS
cord-022353-q2k2krnm	1208	5	have	have	VBP
cord-022353-q2k2krnm	1208	6	shown	show	VBN
cord-022353-q2k2krnm	1208	7	that	that	IN
cord-022353-q2k2krnm	1208	8	oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1208	9	is	be	VBZ
cord-022353-q2k2krnm	1208	10	required	require	VBN
cord-022353-q2k2krnm	1208	11	for	for	IN
cord-022353-q2k2krnm	1208	12	milk	milk	NN
cord-022353-q2k2krnm	1208	13	let	let	VBD
cord-022353-q2k2krnm	1208	14	down	down	RP
cord-022353-q2k2krnm	1208	15	by	by	IN
cord-022353-q2k2krnm	1208	16	the	the	DT
cord-022353-q2k2krnm	1208	17	mammary	mammary	JJ
cord-022353-q2k2krnm	1208	18	gland	gland	NN
cord-022353-q2k2krnm	1208	19	as	as	RB
cord-022353-q2k2krnm	1208	20	well	well	RB
cord-022353-q2k2krnm	1208	21	as	as	IN
cord-022353-q2k2krnm	1208	22	for	for	IN
cord-022353-q2k2krnm	1208	23	postpartum	postpartum	NN
cord-022353-q2k2krnm	1208	24	alveolar	alveolar	JJ
cord-022353-q2k2krnm	1208	25	proliferation	proliferation	NN
cord-022353-q2k2krnm	1208	26	.	.	.
cord-022353-q2k2krnm	1209	1	In	in	IN
cord-022353-q2k2krnm	1209	2	males	male	NNS
cord-022353-q2k2krnm	1209	3	,	,	,
cord-022353-q2k2krnm	1209	4	oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1209	5	is	be	VBZ
cord-022353-q2k2krnm	1209	6	required	require	VBN
cord-022353-q2k2krnm	1209	7	for	for	IN
cord-022353-q2k2krnm	1209	8	normal	normal	JJ
cord-022353-q2k2krnm	1209	9	spermiation	spermiation	NN
cord-022353-q2k2krnm	1209	10	and	and	CC
cord-022353-q2k2krnm	1209	11	sperm	sperm	NN
cord-022353-q2k2krnm	1209	12	transfer	transfer	NN
cord-022353-q2k2krnm	1209	13	.	.	.
cord-022353-q2k2krnm	1210	1	In	in	IN
cord-022353-q2k2krnm	1210	2	both	both	DT
cord-022353-q2k2krnm	1210	3	genders	gender	NNS
cord-022353-q2k2krnm	1210	4	,	,	,
cord-022353-q2k2krnm	1210	5	oxytocin	oxytocin	NNS
cord-022353-q2k2krnm	1210	6	helps	help	VBZ
cord-022353-q2k2krnm	1210	7	control	control	VB
cord-022353-q2k2krnm	1210	8	normal	normal	JJ
cord-022353-q2k2krnm	1210	9	blood	blood	NN
cord-022353-q2k2krnm	1210	10	pressure	pressure	NN
cord-022353-q2k2krnm	1210	11	and	and	CC
cord-022353-q2k2krnm	1210	12	salt	salt	NN
cord-022353-q2k2krnm	1210	13	intake	intake	NN
cord-022353-q2k2krnm	1210	14	.	.	.
cord-022353-q2k2krnm	1211	1	KOs	KOs	NNP
cord-022353-q2k2krnm	1211	2	display	display	NN
cord-022353-q2k2krnm	1211	3	reduced	reduce	VBN
cord-022353-q2k2krnm	1211	4	aggression	aggression	NN
cord-022353-q2k2krnm	1211	5	and	and	CC
cord-022353-q2k2krnm	1211	6	a	a	DT
cord-022353-q2k2krnm	1211	7	striking	striking	JJ
cord-022353-q2k2krnm	1211	8	deficit	deficit	NN
cord-022353-q2k2krnm	1211	9	in	in	IN
cord-022353-q2k2krnm	1211	10	the	the	DT
cord-022353-q2k2krnm	1211	11	ability	ability	NN
cord-022353-q2k2krnm	1211	12	to	to	TO
cord-022353-q2k2krnm	1211	13	recognize	recognize	VB
cord-022353-q2k2krnm	1211	14	a	a	DT
cord-022353-q2k2krnm	1211	15	previously	previously	RB
cord-022353-q2k2krnm	1211	16	encountered	encounter	VBN
cord-022353-q2k2krnm	1211	17	mouse	mouse	NN
cord-022353-q2k2krnm	1211	18	(	(	-LRB-
cord-022353-q2k2krnm	1211	19	Young	Young	NNP
cord-022353-q2k2krnm	1211	20	and	and	CC
cord-022353-q2k2krnm	1211	21	Gainer	Gainer	NNP
cord-022353-q2k2krnm	1211	22	2003	2003	CD
cord-022353-q2k2krnm	1211	23	)	)	-RRB-
cord-022353-q2k2krnm	1211	24	.	.	.
cord-022353-q2k2krnm	1212	1	Oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1212	2	may	may	MD
cord-022353-q2k2krnm	1212	3	be	be	VB
cord-022353-q2k2krnm	1212	4	quantified	quantify	VBN
cord-022353-q2k2krnm	1212	5	in	in	IN
cord-022353-q2k2krnm	1212	6	mice	mouse	NNS
cord-022353-q2k2krnm	1212	7	using	use	VBG
cord-022353-q2k2krnm	1212	8	commercially	commercially	RB
cord-022353-q2k2krnm	1212	9	available	available	JJ
cord-022353-q2k2krnm	1212	10	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1212	11	kits	kit	NNS
cord-022353-q2k2krnm	1212	12	or	or	CC
cord-022353-q2k2krnm	1212	13	by	by	IN
cord-022353-q2k2krnm	1212	14	species	species	NN
cord-022353-q2k2krnm	1212	15	-	-	HYPH
cord-022353-q2k2krnm	1212	16	specific	specific	JJ
cord-022353-q2k2krnm	1212	17	RIA	RIA	NNP
cord-022353-q2k2krnm	1212	18	.	.	.
cord-022353-q2k2krnm	1213	1	Values	value	NNS
cord-022353-q2k2krnm	1213	2	in	in	IN
cord-022353-q2k2krnm	1213	3	one	one	CD
cord-022353-q2k2krnm	1213	4	recent	recent	JJ
cord-022353-q2k2krnm	1213	5	publication	publication	NN
cord-022353-q2k2krnm	1213	6	showed	show	VBD
cord-022353-q2k2krnm	1213	7	plasma	plasma	NN
cord-022353-q2k2krnm	1213	8	oxytocin	oxytocin	NNS
cord-022353-q2k2krnm	1213	9	at	at	IN
cord-022353-q2k2krnm	1213	10	1.5	1.5	CD
cord-022353-q2k2krnm	1213	11	_	_	NN
cord-022353-q2k2krnm	1214	1	+	+	CC
cord-022353-q2k2krnm	1214	2	0.6	0.6	CD
cord-022353-q2k2krnm	1214	3	pg	pg	NN
cord-022353-q2k2krnm	1214	4	/	/	SYM
cord-022353-q2k2krnm	1214	5	ml	ml	NN
cord-022353-q2k2krnm	1214	6	in	in	IN
cord-022353-q2k2krnm	1214	7	male	male	JJ
cord-022353-q2k2krnm	1214	8	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1214	9	mice	mouse	NNS
cord-022353-q2k2krnm	1214	10	)	)	-RRB-
cord-022353-q2k2krnm	1214	11	.	.	.
cord-022353-q2k2krnm	1215	1	AVP	AVP	NNP
cord-022353-q2k2krnm	1215	2	is	be	VBZ
cord-022353-q2k2krnm	1215	3	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1215	4	and	and	CC
cord-022353-q2k2krnm	1215	5	released	release	VBN
cord-022353-q2k2krnm	1215	6	by	by	IN
cord-022353-q2k2krnm	1215	7	the	the	DT
cord-022353-q2k2krnm	1215	8	same	same	JJ
cord-022353-q2k2krnm	1215	9	neurons	neuron	NNS
cord-022353-q2k2krnm	1215	10	previously	previously	RB
cord-022353-q2k2krnm	1215	11	described	describe	VBN
cord-022353-q2k2krnm	1215	12	for	for	IN
cord-022353-q2k2krnm	1215	13	oxytocin	oxytocin	NNS
cord-022353-q2k2krnm	1215	14	,	,	,
cord-022353-q2k2krnm	1215	15	although	although	IN
cord-022353-q2k2krnm	1215	16	the	the	DT
cord-022353-q2k2krnm	1215	17	two	two	CD
cord-022353-q2k2krnm	1215	18	secretory	secretory	NN
cord-022353-q2k2krnm	1215	19	granules	granule	NNS
cord-022353-q2k2krnm	1215	20	rarely	rarely	RB
cord-022353-q2k2krnm	1215	21	colocalize	colocalize	VBP
cord-022353-q2k2krnm	1215	22	in	in	IN
cord-022353-q2k2krnm	1215	23	the	the	DT
cord-022353-q2k2krnm	1215	24	same	same	JJ
cord-022353-q2k2krnm	1215	25	neuron	neuron	NN
cord-022353-q2k2krnm	1215	26	.	.	.
cord-022353-q2k2krnm	1216	1	The	the	DT
cord-022353-q2k2krnm	1216	2	carrier	carrier	NN
cord-022353-q2k2krnm	1216	3	protein	protein	NN
cord-022353-q2k2krnm	1216	4	for	for	IN
cord-022353-q2k2krnm	1216	5	AVP	AVP	NNP
cord-022353-q2k2krnm	1216	6	is	be	VBZ
cord-022353-q2k2krnm	1216	7	neurophysin	neurophysin	NNP
cord-022353-q2k2krnm	1216	8	II	II	NNP
cord-022353-q2k2krnm	1216	9	.	.	.
cord-022353-q2k2krnm	1217	1	AVP	AVP	NNP
cord-022353-q2k2krnm	1217	2	is	be	VBZ
cord-022353-q2k2krnm	1217	3	released	release	VBN
cord-022353-q2k2krnm	1217	4	from	from	IN
cord-022353-q2k2krnm	1217	5	neuron	neuron	NN
cord-022353-q2k2krnm	1217	6	secretory	secretory	JJ
cord-022353-q2k2krnm	1217	7	granules	granule	NNS
cord-022353-q2k2krnm	1217	8	by	by	IN
cord-022353-q2k2krnm	1217	9	electrical	electrical	JJ
cord-022353-q2k2krnm	1217	10	signals	signal	NNS
cord-022353-q2k2krnm	1217	11	from	from	IN
cord-022353-q2k2krnm	1217	12	osmoreceptors	osmoreceptor	NNS
cord-022353-q2k2krnm	1217	13	measuring	measure	VBG
cord-022353-q2k2krnm	1217	14	the	the	DT
cord-022353-q2k2krnm	1217	15	osmolarity	osmolarity	NN
cord-022353-q2k2krnm	1217	16	of	of	IN
cord-022353-q2k2krnm	1217	17	extracellular	extracellular	JJ
cord-022353-q2k2krnm	1217	18	fluid	fluid	NN
cord-022353-q2k2krnm	1217	19	.	.	.
cord-022353-q2k2krnm	1218	1	Action	action	NN
cord-022353-q2k2krnm	1218	2	potentials	potential	NNS
cord-022353-q2k2krnm	1218	3	,	,	,
cord-022353-q2k2krnm	1218	4	generated	generate	VBN
cord-022353-q2k2krnm	1218	5	in	in	IN
cord-022353-q2k2krnm	1218	6	the	the	DT
cord-022353-q2k2krnm	1218	7	receptors	receptor	NNS
cord-022353-q2k2krnm	1218	8	,	,	,
cord-022353-q2k2krnm	1218	9	cause	cause	VBP
cord-022353-q2k2krnm	1218	10	calcium	calcium	NN
cord-022353-q2k2krnm	1218	11	influx	influx	NN
cord-022353-q2k2krnm	1218	12	into	into	IN
cord-022353-q2k2krnm	1218	13	axon	axon	NN
cord-022353-q2k2krnm	1218	14	terminals	terminal	NNS
cord-022353-q2k2krnm	1218	15	and	and	CC
cord-022353-q2k2krnm	1218	16	exocytosis	exocytosis	NN
cord-022353-q2k2krnm	1218	17	of	of	IN
cord-022353-q2k2krnm	1218	18	AVE	AVE	NNP
cord-022353-q2k2krnm	1218	19	AVP	AVP	NNP
cord-022353-q2k2krnm	1218	20	is	be	VBZ
cord-022353-q2k2krnm	1218	21	transported	transport	VBN
cord-022353-q2k2krnm	1218	22	in	in	IN
cord-022353-q2k2krnm	1218	23	the	the	DT
cord-022353-q2k2krnm	1218	24	blood	blood	NN
cord-022353-q2k2krnm	1218	25	to	to	IN
cord-022353-q2k2krnm	1218	26	the	the	DT
cord-022353-q2k2krnm	1218	27	kidneys	kidney	NNS
cord-022353-q2k2krnm	1218	28	,	,	,
cord-022353-q2k2krnm	1218	29	where	where	WRB
cord-022353-q2k2krnm	1218	30	it	-PRON-	PRP
cord-022353-q2k2krnm	1218	31	binds	bind	VBZ
cord-022353-q2k2krnm	1218	32	receptors	receptor	NNS
cord-022353-q2k2krnm	1218	33	in	in	IN
cord-022353-q2k2krnm	1218	34	the	the	DT
cord-022353-q2k2krnm	1218	35	distal	distal	JJ
cord-022353-q2k2krnm	1218	36	segment	segment	NN
cord-022353-q2k2krnm	1218	37	of	of	IN
cord-022353-q2k2krnm	1218	38	the	the	DT
cord-022353-q2k2krnm	1218	39	nephron	nephron	NN
cord-022353-q2k2krnm	1218	40	and	and	CC
cord-022353-q2k2krnm	1218	41	collecting	collect	VBG
cord-022353-q2k2krnm	1218	42	ducts	duct	NNS
cord-022353-q2k2krnm	1218	43	leading	lead	VBG
cord-022353-q2k2krnm	1218	44	to	to	IN
cord-022353-q2k2krnm	1218	45	increased	increase	VBN
cord-022353-q2k2krnm	1218	46	resorption	resorption	NN
cord-022353-q2k2krnm	1218	47	of	of	IN
cord-022353-q2k2krnm	1218	48	water	water	NN
cord-022353-q2k2krnm	1218	49	(	(	-LRB-
cord-022353-q2k2krnm	1218	50	Reimers	reimer	NNS
cord-022353-q2k2krnm	1218	51	1999	1999	CD
cord-022353-q2k2krnm	1218	52	)	)	-RRB-
cord-022353-q2k2krnm	1218	53	.	.	.
cord-022353-q2k2krnm	1219	1	There	there	EX
cord-022353-q2k2krnm	1219	2	are	be	VBP
cord-022353-q2k2krnm	1219	3	three	three	CD
cord-022353-q2k2krnm	1219	4	AVP	AVP	NNP
cord-022353-q2k2krnm	1219	5	receptors	receptor	NNS
cord-022353-q2k2krnm	1219	6	,	,	,
cord-022353-q2k2krnm	1219	7	V	V	NNP
cord-022353-q2k2krnm	1219	8	l	l	NNP
cord-022353-q2k2krnm	1219	9	aR	aR	NNP
cord-022353-q2k2krnm	1219	10	,	,	,
cord-022353-q2k2krnm	1219	11	VlbR	VlbR	NNP
cord-022353-q2k2krnm	1219	12	,	,	,
cord-022353-q2k2krnm	1219	13	and	and	CC
cord-022353-q2k2krnm	1219	14	V2R	v2r	NN
cord-022353-q2k2krnm	1219	15	;	;	:
cord-022353-q2k2krnm	1219	16	and	and	CC
cord-022353-q2k2krnm	1219	17	these	these	DT
cord-022353-q2k2krnm	1219	18	are	be	VBP
cord-022353-q2k2krnm	1219	19	all	all	DT
cord-022353-q2k2krnm	1219	20	G	g	NN
cord-022353-q2k2krnm	1219	21	-	-	HYPH
cord-022353-q2k2krnm	1219	22	protein	protein	NN
cord-022353-q2k2krnm	1219	23	coupled	coupled	JJ
cord-022353-q2k2krnm	1219	24	receptors	receptor	NNS
cord-022353-q2k2krnm	1219	25	.	.	.
cord-022353-q2k2krnm	1220	1	Nonsense	nonsense	NN
cord-022353-q2k2krnm	1220	2	mutations	mutation	NNS
cord-022353-q2k2krnm	1220	3	of	of	IN
cord-022353-q2k2krnm	1220	4	the	the	DT
cord-022353-q2k2krnm	1220	5	AVP	AVP	NNP
cord-022353-q2k2krnm	1220	6	gene	gene	NN
cord-022353-q2k2krnm	1220	7	(	(	-LRB-
cord-022353-q2k2krnm	1220	8	as	as	IN
cord-022353-q2k2krnm	1220	9	seen	see	VBN
cord-022353-q2k2krnm	1220	10	in	in	IN
cord-022353-q2k2krnm	1220	11	the	the	DT
cord-022353-q2k2krnm	1220	12	Brattleboro	Brattleboro	NNP
cord-022353-q2k2krnm	1220	13	rat	rat	NN
cord-022353-q2k2krnm	1220	14	)	)	-RRB-
cord-022353-q2k2krnm	1220	15	or	or	CC
cord-022353-q2k2krnm	1220	16	KD	KD	NNP
cord-022353-q2k2krnm	1220	17	mice	mouse	NNS
cord-022353-q2k2krnm	1220	18	develop	develop	VB
cord-022353-q2k2krnm	1220	19	neurohypophysial	neurohypophysial	JJ
cord-022353-q2k2krnm	1220	20	(	(	-LRB-
cord-022353-q2k2krnm	1220	21	central	central	NNP
cord-022353-q2k2krnm	1220	22	)	)	-RRB-
cord-022353-q2k2krnm	1220	23	diabetes	diabete	VBZ
cord-022353-q2k2krnm	1220	24	insipidus	insipidus	NN
cord-022353-q2k2krnm	1220	25	.	.	.
cord-022353-q2k2krnm	1221	1	Mice	mouse	NNS
cord-022353-q2k2krnm	1221	2	with	with	IN
cord-022353-q2k2krnm	1221	3	the	the	DT
cord-022353-q2k2krnm	1221	4	V2R	v2r	NN
cord-022353-q2k2krnm	1221	5	knocked	knock	VBN
cord-022353-q2k2krnm	1221	6	out	out	RP
cord-022353-q2k2krnm	1221	7	develop	develop	VB
cord-022353-q2k2krnm	1221	8	nephrogenic	nephrogenic	JJ
cord-022353-q2k2krnm	1221	9	diabetes	diabetes	NN
cord-022353-q2k2krnm	1221	10	insipidus	insipidus	NN
cord-022353-q2k2krnm	1221	11	characterized	characterize	VBN
cord-022353-q2k2krnm	1221	12	by	by	IN
cord-022353-q2k2krnm	1221	13	polyuria	polyuria	NN
cord-022353-q2k2krnm	1221	14	,	,	,
cord-022353-q2k2krnm	1221	15	polydipsia	polydipsia	NN
cord-022353-q2k2krnm	1221	16	,	,	,
cord-022353-q2k2krnm	1221	17	and	and	CC
cord-022353-q2k2krnm	1221	18	failure	failure	NN
cord-022353-q2k2krnm	1221	19	to	to	TO
cord-022353-q2k2krnm	1221	20	concentrate	concentrate	VB
cord-022353-q2k2krnm	1221	21	urine	urine	NN
cord-022353-q2k2krnm	1221	22	.	.	.
cord-022353-q2k2krnm	1222	1	When	when	WRB
cord-022353-q2k2krnm	1222	2	the	the	DT
cord-022353-q2k2krnm	1222	3	V1	V1	NNP
cord-022353-q2k2krnm	1222	4	aR	aR	NNP
cord-022353-q2k2krnm	1222	5	gene	gene	NN
cord-022353-q2k2krnm	1222	6	is	be	VBZ
cord-022353-q2k2krnm	1222	7	knocked	knock	VBN
cord-022353-q2k2krnm	1222	8	out	out	RP
cord-022353-q2k2krnm	1222	9	,	,	,
cord-022353-q2k2krnm	1222	10	mice	mouse	NNS
cord-022353-q2k2krnm	1222	11	develop	develop	VBP
cord-022353-q2k2krnm	1222	12	an	an	DT
cord-022353-q2k2krnm	1222	13	enhanced	enhance	VBN
cord-022353-q2k2krnm	1222	14	proliferation	proliferation	NN
cord-022353-q2k2krnm	1222	15	of	of	IN
cord-022353-q2k2krnm	1222	16	splenic	splenic	JJ
cord-022353-q2k2krnm	1222	17	B	b	NN
cord-022353-q2k2krnm	1222	18	cells	cell	NNS
cord-022353-q2k2krnm	1222	19	and	and	CC
cord-022353-q2k2krnm	1222	20	enhanced	enhance	VBN
cord-022353-q2k2krnm	1222	21	IgG1	igg1	NN
cord-022353-q2k2krnm	1222	22	and	and	CC
cord-022353-q2k2krnm	1222	23	IgG2b	IgG2b	NNP
cord-022353-q2k2krnm	1222	24	production	production	NN
cord-022353-q2k2krnm	1222	25	to	to	IN
cord-022353-q2k2krnm	1222	26	thymicdependent	thymicdependent	NN
cord-022353-q2k2krnm	1222	27	antigens	antigen	NNS
cord-022353-q2k2krnm	1222	28	.	.	.
cord-022353-q2k2krnm	1223	1	When	when	WRB
cord-022353-q2k2krnm	1223	2	V	V	NNP
cord-022353-q2k2krnm	1223	3	lbR	lbR	NNP
cord-022353-q2k2krnm	1223	4	is	be	VBZ
cord-022353-q2k2krnm	1223	5	knocked	knock	VBN
cord-022353-q2k2krnm	1223	6	out	out	RP
cord-022353-q2k2krnm	1223	7	the	the	DT
cord-022353-q2k2krnm	1223	8	mice	mice	NN
cord-022353-q2k2krnm	1223	9	display	display	VB
cord-022353-q2k2krnm	1223	10	a	a	DT
cord-022353-q2k2krnm	1223	11	marked	marked	JJ
cord-022353-q2k2krnm	1223	12	reduction	reduction	NN
cord-022353-q2k2krnm	1223	13	in	in	IN
cord-022353-q2k2krnm	1223	14	social	social	JJ
cord-022353-q2k2krnm	1223	15	aggression	aggression	NN
cord-022353-q2k2krnm	1223	16	and	and	CC
cord-022353-q2k2krnm	1223	17	a	a	DT
cord-022353-q2k2krnm	1223	18	deficit	deficit	NN
cord-022353-q2k2krnm	1223	19	in	in	IN
cord-022353-q2k2krnm	1223	20	social	social	JJ
cord-022353-q2k2krnm	1223	21	recognition	recognition	NN
cord-022353-q2k2krnm	1223	22	(	(	-LRB-
cord-022353-q2k2krnm	1223	23	Young	Young	NNP
cord-022353-q2k2krnm	1223	24	and	and	CC
cord-022353-q2k2krnm	1223	25	Gainer	Gainer	NNP
cord-022353-q2k2krnm	1223	26	2003	2003	CD
cord-022353-q2k2krnm	1223	27	)	)	-RRB-
cord-022353-q2k2krnm	1223	28	.	.	.
cord-022353-q2k2krnm	1224	1	AVP	AVP	NNP
cord-022353-q2k2krnm	1224	2	can	can	MD
cord-022353-q2k2krnm	1224	3	be	be	VB
cord-022353-q2k2krnm	1224	4	measured	measure	VBN
cord-022353-q2k2krnm	1224	5	by	by	IN
cord-022353-q2k2krnm	1224	6	RIA	RIA	NNP
cord-022353-q2k2krnm	1224	7	or	or	CC
cord-022353-q2k2krnm	1224	8	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1224	9	and	and	CC
cord-022353-q2k2krnm	1224	10	the	the	DT
cord-022353-q2k2krnm	1224	11	reported	report	VBN
cord-022353-q2k2krnm	1224	12	values	value	NNS
cord-022353-q2k2krnm	1224	13	in	in	IN
cord-022353-q2k2krnm	1224	14	normal	normal	JJ
cord-022353-q2k2krnm	1224	15	male	male	NN
cord-022353-q2k2krnm	1224	16	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1224	17	mice	mouse	NNS
cord-022353-q2k2krnm	1224	18	are	be	VBP
cord-022353-q2k2krnm	1224	19	5.1	5.1	CD
cord-022353-q2k2krnm	1224	20	+	+	SYM
cord-022353-q2k2krnm	1224	21	1.5	1.5	CD
cord-022353-q2k2krnm	1224	22	pg	pg	NN
cord-022353-q2k2krnm	1224	23	/	/	SYM
cord-022353-q2k2krnm	1224	24	ml	ml	NN
cord-022353-q2k2krnm	1224	25	in	in	IN
cord-022353-q2k2krnm	1224	26	plasma	plasma	NN
cord-022353-q2k2krnm	1224	27	)	)	-RRB-
cord-022353-q2k2krnm	1224	28	.	.	.
cord-022353-q2k2krnm	1225	1	TSH	TSH	NNP
cord-022353-q2k2krnm	1225	2	is	be	VBZ
cord-022353-q2k2krnm	1225	3	a	a	DT
cord-022353-q2k2krnm	1225	4	28-kDa	28-kda	CD
cord-022353-q2k2krnm	1225	5	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	1225	6	made	make	VBN
cord-022353-q2k2krnm	1225	7	by	by	IN
cord-022353-q2k2krnm	1225	8	the	the	DT
cord-022353-q2k2krnm	1225	9	anterior	anterior	JJ
cord-022353-q2k2krnm	1225	10	pituitary	pituitary	JJ
cord-022353-q2k2krnm	1225	11	gland	gland	NN
cord-022353-q2k2krnm	1225	12	on	on	IN
cord-022353-q2k2krnm	1225	13	stimulation	stimulation	NN
cord-022353-q2k2krnm	1225	14	by	by	IN
cord-022353-q2k2krnm	1225	15	thyrotropin	thyrotropin	NN
cord-022353-q2k2krnm	1225	16	-	-	HYPH
cord-022353-q2k2krnm	1225	17	releasing	release	VBG
cord-022353-q2k2krnm	1225	18	hormone	hormone	NN
cord-022353-q2k2krnm	1225	19	(	(	-LRB-
cord-022353-q2k2krnm	1225	20	TRH	TRH	NNP
cord-022353-q2k2krnm	1225	21	)	)	-RRB-
cord-022353-q2k2krnm	1225	22	.	.	.
cord-022353-q2k2krnm	1226	1	TRH	TRH	NNP
cord-022353-q2k2krnm	1226	2	is	be	VBZ
cord-022353-q2k2krnm	1226	3	made	make	VBN
cord-022353-q2k2krnm	1226	4	in	in	IN
cord-022353-q2k2krnm	1226	5	the	the	DT
cord-022353-q2k2krnm	1226	6	hypothalamus	hypothalamus	NN
cord-022353-q2k2krnm	1226	7	.	.	.
cord-022353-q2k2krnm	1227	1	TSH	TSH	NNP
cord-022353-q2k2krnm	1227	2	is	be	VBZ
cord-022353-q2k2krnm	1227	3	secreted	secrete	VBN
cord-022353-q2k2krnm	1227	4	in	in	IN
cord-022353-q2k2krnm	1227	5	a	a	DT
cord-022353-q2k2krnm	1227	6	pulsatile	pulsatile	JJ
cord-022353-q2k2krnm	1227	7	manner	manner	NN
cord-022353-q2k2krnm	1227	8	,	,	,
cord-022353-q2k2krnm	1227	9	similar	similar	JJ
cord-022353-q2k2krnm	1227	10	to	to	IN
cord-022353-q2k2krnm	1227	11	ACTH	ACTH	NNP
cord-022353-q2k2krnm	1227	12	.	.	.
cord-022353-q2k2krnm	1228	1	TSH	tsh	NN
cord-022353-q2k2krnm	1228	2	secretion	secretion	NN
cord-022353-q2k2krnm	1228	3	is	be	VBZ
cord-022353-q2k2krnm	1228	4	regulated	regulate	VBN
cord-022353-q2k2krnm	1228	5	by	by	IN
cord-022353-q2k2krnm	1228	6	triiodothyronine	triiodothyronine	NNP
cord-022353-q2k2krnm	1228	7	(	(	-LRB-
cord-022353-q2k2krnm	1228	8	T3	T3	NNP
cord-022353-q2k2krnm	1228	9	)	)	-RRB-
cord-022353-q2k2krnm	1228	10	,	,	,
cord-022353-q2k2krnm	1228	11	which	which	WDT
cord-022353-q2k2krnm	1228	12	acts	act	VBZ
cord-022353-q2k2krnm	1228	13	on	on	IN
cord-022353-q2k2krnm	1228	14	the	the	DT
cord-022353-q2k2krnm	1228	15	hypothalamus	hypothalamus	NN
cord-022353-q2k2krnm	1228	16	to	to	TO
cord-022353-q2k2krnm	1228	17	inhibit	inhibit	VB
cord-022353-q2k2krnm	1228	18	secretion	secretion	NN
cord-022353-q2k2krnm	1228	19	of	of	IN
cord-022353-q2k2krnm	1228	20	TRH	TRH	NNP
cord-022353-q2k2krnm	1228	21	and	and	CC
cord-022353-q2k2krnm	1228	22	acts	act	VBZ
cord-022353-q2k2krnm	1228	23	on	on	IN
cord-022353-q2k2krnm	1228	24	the	the	DT
cord-022353-q2k2krnm	1228	25	pituitary	pituitary	JJ
cord-022353-q2k2krnm	1228	26	gland	gland	NN
cord-022353-q2k2krnm	1228	27	to	to	TO
cord-022353-q2k2krnm	1228	28	inhibit	inhibit	VB
cord-022353-q2k2krnm	1228	29	TSH	tsh	NN
cord-022353-q2k2krnm	1228	30	synthesis	synthesis	NN
cord-022353-q2k2krnm	1228	31	(	(	-LRB-
cord-022353-q2k2krnm	1228	32	Reimers	reimer	NNS
cord-022353-q2k2krnm	1228	33	1999	1999	CD
cord-022353-q2k2krnm	1228	34	)	)	-RRB-
cord-022353-q2k2krnm	1228	35	.	.	.
cord-022353-q2k2krnm	1229	1	TSH	TSH	NNP
cord-022353-q2k2krnm	1229	2	plays	play	VBZ
cord-022353-q2k2krnm	1229	3	a	a	DT
cord-022353-q2k2krnm	1229	4	role	role	NN
cord-022353-q2k2krnm	1229	5	in	in	IN
cord-022353-q2k2krnm	1229	6	stimulating	stimulate	VBG
cord-022353-q2k2krnm	1229	7	the	the	DT
cord-022353-q2k2krnm	1229	8	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1229	9	gland	gland	NN
cord-022353-q2k2krnm	1229	10	to	to	TO
cord-022353-q2k2krnm	1229	11	produce	produce	VB
cord-022353-q2k2krnm	1229	12	thyroxine	thyroxine	NN
cord-022353-q2k2krnm	1229	13	and	and	CC
cord-022353-q2k2krnm	1229	14	it	-PRON-	PRP
cord-022353-q2k2krnm	1229	15	influences	influence	VBZ
cord-022353-q2k2krnm	1229	16	the	the	DT
cord-022353-q2k2krnm	1229	17	outcome	outcome	NN
cord-022353-q2k2krnm	1229	18	of	of	IN
cord-022353-q2k2krnm	1229	19	T	t	NN
cord-022353-q2k2krnm	1229	20	-	-	HYPH
cord-022353-q2k2krnm	1229	21	cell	cell	NN
cord-022353-q2k2krnm	1229	22	development	development	NN
cord-022353-q2k2krnm	1229	23	in	in	IN
cord-022353-q2k2krnm	1229	24	thymus	thymus	NN
cord-022353-q2k2krnm	1229	25	and	and	CC
cord-022353-q2k2krnm	1229	26	intestine	intestine	NN
cord-022353-q2k2krnm	1229	27	.	.	.
cord-022353-q2k2krnm	1230	1	In	in	IN
cord-022353-q2k2krnm	1230	2	addition	addition	NN
cord-022353-q2k2krnm	1230	3	to	to	IN
cord-022353-q2k2krnm	1230	4	the	the	DT
cord-022353-q2k2krnm	1230	5	thyroid	thyroid	NN
cord-022353-q2k2krnm	1230	6	gland	gland	NN
cord-022353-q2k2krnm	1230	7	,	,	,
cord-022353-q2k2krnm	1230	8	TSH	tsh	NN
cord-022353-q2k2krnm	1230	9	receptors	receptor	NNS
cord-022353-q2k2krnm	1230	10	are	be	VBP
cord-022353-q2k2krnm	1230	11	found	find	VBN
cord-022353-q2k2krnm	1230	12	on	on	IN
cord-022353-q2k2krnm	1230	13	many	many	JJ
cord-022353-q2k2krnm	1230	14	different	different	JJ
cord-022353-q2k2krnm	1230	15	populations	population	NNS
cord-022353-q2k2krnm	1230	16	of	of	IN
cord-022353-q2k2krnm	1230	17	hematopoietic	hematopoietic	JJ
cord-022353-q2k2krnm	1230	18	cells	cell	NNS
cord-022353-q2k2krnm	1230	19	in	in	IN
cord-022353-q2k2krnm	1230	20	bone	bone	NN
cord-022353-q2k2krnm	1230	21	marrow	marrow	NN
cord-022353-q2k2krnm	1230	22	,	,	,
cord-022353-q2k2krnm	1230	23	subsets	subset	NNS
cord-022353-q2k2krnm	1230	24	of	of	IN
cord-022353-q2k2krnm	1230	25	dendritic	dendritic	JJ
cord-022353-q2k2krnm	1230	26	cells	cell	NNS
cord-022353-q2k2krnm	1230	27	,	,	,
cord-022353-q2k2krnm	1230	28	monocytes	monocyte	NNS
cord-022353-q2k2krnm	1230	29	,	,	,
cord-022353-q2k2krnm	1230	30	and	and	CC
cord-022353-q2k2krnm	1230	31	lymphocytes	lymphocyte	NNS
cord-022353-q2k2krnm	1230	32	in	in	IN
cord-022353-q2k2krnm	1230	33	the	the	DT
cord-022353-q2k2krnm	1230	34	spleen	spleen	NNS
cord-022353-q2k2krnm	1230	35	and	and	CC
cord-022353-q2k2krnm	1230	36	lymph	lymph	NN
cord-022353-q2k2krnm	1230	37	nodes	node	NNS
cord-022353-q2k2krnm	1230	38	(	(	-LRB-
cord-022353-q2k2krnm	1230	39	Klein	Klein	NNP
cord-022353-q2k2krnm	1230	40	2003	2003	CD
cord-022353-q2k2krnm	1230	41	;	;	:
cord-022353-q2k2krnm	1230	42	Scofield	Scofield	NNP
cord-022353-q2k2krnm	1230	43	et	et	NNP
cord-022353-q2k2krnm	1230	44	al	al	NNP
cord-022353-q2k2krnm	1230	45	.	.	NNP
cord-022353-q2k2krnm	1230	46	2005	2005	CD
cord-022353-q2k2krnm	1230	47	)	)	-RRB-
cord-022353-q2k2krnm	1230	48	.	.	.
cord-022353-q2k2krnm	1231	1	KO	KO	NNP
cord-022353-q2k2krnm	1231	2	mice	mouse	NNS
cord-022353-q2k2krnm	1231	3	have	have	VBP
cord-022353-q2k2krnm	1231	4	been	be	VBN
cord-022353-q2k2krnm	1231	5	created	create	VBN
cord-022353-q2k2krnm	1231	6	in	in	IN
cord-022353-q2k2krnm	1231	7	which	which	WDT
cord-022353-q2k2krnm	1231	8	genes	gene	NNS
cord-022353-q2k2krnm	1231	9	for	for	IN
cord-022353-q2k2krnm	1231	10	TRH	TRH	NNP
cord-022353-q2k2krnm	1231	11	(	(	-LRB-
cord-022353-q2k2krnm	1231	12	Wells	Wells	NNP
cord-022353-q2k2krnm	1231	13	and	and	CC
cord-022353-q2k2krnm	1231	14	Murphy	Murphy	NNP
cord-022353-q2k2krnm	1231	15	2003	2003	CD
cord-022353-q2k2krnm	1231	16	;	;	:
cord-022353-q2k2krnm	1231	17	Yamada	Yamada	NNP
cord-022353-q2k2krnm	1231	18	et	et	NNP
cord-022353-q2k2krnm	1231	19	al	al	NNP
cord-022353-q2k2krnm	1231	20	.	.	NNP
cord-022353-q2k2krnm	1231	21	2003	2003	CD
cord-022353-q2k2krnm	1231	22	)	)	-RRB-
cord-022353-q2k2krnm	1231	23	and	and	CC
cord-022353-q2k2krnm	1231	24	TSH	tsh	NN
cord-022353-q2k2krnm	1231	25	receptors	receptor	NNS
cord-022353-q2k2krnm	1231	26	(	(	-LRB-
cord-022353-q2k2krnm	1231	27	Biesiada	Biesiada	NNP
cord-022353-q2k2krnm	1231	28	et	et	NNP
cord-022353-q2k2krnm	1231	29	al	al	NNP
cord-022353-q2k2krnm	1231	30	.	.	.
cord-022353-q2k2krnm	1231	31	1996	1996	CD
cord-022353-q2k2krnm	1231	32	)	)	-RRB-
cord-022353-q2k2krnm	1231	33	have	have	VBP
cord-022353-q2k2krnm	1231	34	been	be	VBN
cord-022353-q2k2krnm	1231	35	deleted	delete	VBN
cord-022353-q2k2krnm	1231	36	.	.	.
cord-022353-q2k2krnm	1232	1	In	in	IN
cord-022353-q2k2krnm	1232	2	addition	addition	NN
cord-022353-q2k2krnm	1232	3	,	,	,
cord-022353-q2k2krnm	1232	4	spontaneous	spontaneous	JJ
cord-022353-q2k2krnm	1232	5	mutations	mutation	NNS
cord-022353-q2k2krnm	1232	6	in	in	IN
cord-022353-q2k2krnm	1232	7	the	the	DT
cord-022353-q2k2krnm	1232	8	Pitl	Pitl	NNP
cord-022353-q2k2krnm	1232	9	gene	gene	NN
cord-022353-q2k2krnm	1232	10	lead	lead	NN
cord-022353-q2k2krnm	1232	11	to	to	IN
cord-022353-q2k2krnm	1232	12	deficiencies	deficiency	NNS
cord-022353-q2k2krnm	1232	13	of	of	IN
cord-022353-q2k2krnm	1232	14	GH	GH	NNP
cord-022353-q2k2krnm	1232	15	,	,	,
cord-022353-q2k2krnm	1232	16	PRL	PRL	NNP
cord-022353-q2k2krnm	1232	17	,	,	,
cord-022353-q2k2krnm	1232	18	and	and	CC
cord-022353-q2k2krnm	1232	19	TSH	tsh	NN
cord-022353-q2k2krnm	1232	20	(	(	-LRB-
cord-022353-q2k2krnm	1232	21	Yeap	Yeap	NNP
cord-022353-q2k2krnm	1232	22	and	and	CC
cord-022353-q2k2krnm	1232	23	Leedman	Leedman	NNP
cord-022353-q2k2krnm	1232	24	1999	1999	CD
cord-022353-q2k2krnm	1232	25	)	)	-RRB-
cord-022353-q2k2krnm	1232	26	.	.	.
cord-022353-q2k2krnm	1233	1	TSH	TSH	NNP
cord-022353-q2k2krnm	1233	2	is	be	VBZ
cord-022353-q2k2krnm	1233	3	measured	measure	VBN
cord-022353-q2k2krnm	1233	4	by	by	IN
cord-022353-q2k2krnm	1233	5	RIA	RIA	NNP
cord-022353-q2k2krnm	1233	6	and	and	CC
cord-022353-q2k2krnm	1233	7	reference	reference	NN
cord-022353-q2k2krnm	1233	8	ranges	range	NNS
cord-022353-q2k2krnm	1233	9	established	establish	VBN
cord-022353-q2k2krnm	1233	10	around	around	IN
cord-022353-q2k2krnm	1233	11	a	a	DT
cord-022353-q2k2krnm	1233	12	3.1	3.1	CD
cord-022353-q2k2krnm	1233	13	U	U	NNP
cord-022353-q2k2krnm	1233	14	/	/	SYM
cord-022353-q2k2krnm	1233	15	mg	mg	NNP
cord-022353-q2k2krnm	1233	16	reference	reference	NN
cord-022353-q2k2krnm	1233	17	standard	standard	NN
cord-022353-q2k2krnm	1233	18	were	be	VBD
cord-022353-q2k2krnm	1233	19	1	1	CD
cord-022353-q2k2krnm	1233	20	-	-	SYM
cord-022353-q2k2krnm	1233	21	90	90	CD
cord-022353-q2k2krnm	1233	22	ng	ng	NN
cord-022353-q2k2krnm	1233	23	/	/	SYM
cord-022353-q2k2krnm	1233	24	ml	ml	NNP
cord-022353-q2k2krnm	1233	25	(	(	-LRB-
cord-022353-q2k2krnm	1233	26	DePaolo	DePaolo	NNP
cord-022353-q2k2krnm	1233	27	and	and	CC
cord-022353-q2k2krnm	1233	28	Masoro	Masoro	NNP
cord-022353-q2k2krnm	1233	29	1989	1989	CD
cord-022353-q2k2krnm	1233	30	)	)	-RRB-
cord-022353-q2k2krnm	1233	31	.	.	.
cord-022353-q2k2krnm	1234	1	11	11	CD
cord-022353-q2k2krnm	1234	2	.	.	.
cord-022353-q2k2krnm	1235	1	Thyroxine	Thyroxine	NNP
cord-022353-q2k2krnm	1235	2	(	(	-LRB-
cord-022353-q2k2krnm	1235	3	T4	T4	NNP
cord-022353-q2k2krnm	1235	4	)	)	-RRB-
cord-022353-q2k2krnm	1235	5	and	and	CC
cord-022353-q2k2krnm	1235	6	Triiodothyronine	Triiodothyronine	NNP
cord-022353-q2k2krnm	1236	1	(	(	-LRB-
cord-022353-q2k2krnm	1236	2	T3	T3	NNP
cord-022353-q2k2krnm	1236	3	)	)	-RRB-
cord-022353-q2k2krnm	1236	4	T	T	NNP
cord-022353-q2k2krnm	1236	5	4	4	CD
cord-022353-q2k2krnm	1236	6	is	be	VBZ
cord-022353-q2k2krnm	1236	7	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1236	8	entirely	entirely	RB
cord-022353-q2k2krnm	1236	9	in	in	IN
cord-022353-q2k2krnm	1236	10	the	the	DT
cord-022353-q2k2krnm	1236	11	thyroid	thyroid	NN
cord-022353-q2k2krnm	1236	12	gland	gland	NN
cord-022353-q2k2krnm	1236	13	,	,	,
cord-022353-q2k2krnm	1236	14	whereas	whereas	IN
cord-022353-q2k2krnm	1236	15	T	T	NNP
cord-022353-q2k2krnm	1236	16	3	3	CD
cord-022353-q2k2krnm	1236	17	is	be	VBZ
cord-022353-q2k2krnm	1236	18	produced	produce	VBN
cord-022353-q2k2krnm	1236	19	primarily	primarily	RB
cord-022353-q2k2krnm	1236	20	by	by	IN
cord-022353-q2k2krnm	1236	21	conversion	conversion	NN
cord-022353-q2k2krnm	1236	22	of	of	IN
cord-022353-q2k2krnm	1236	23	T	T	NNP
cord-022353-q2k2krnm	1236	24	4	4	CD
cord-022353-q2k2krnm	1236	25	to	to	IN
cord-022353-q2k2krnm	1236	26	T	T	NNP
cord-022353-q2k2krnm	1236	27	3	3	CD
cord-022353-q2k2krnm	1236	28	in	in	IN
cord-022353-q2k2krnm	1236	29	extrathyroidal	extrathyroidal	FW
cord-022353-q2k2krnm	1236	30	tissues	tissue	NNS
cord-022353-q2k2krnm	1236	31	.	.	.
cord-022353-q2k2krnm	1237	1	In	in	IN
cord-022353-q2k2krnm	1237	2	the	the	DT
cord-022353-q2k2krnm	1237	3	thyroid	thyroid	NN
cord-022353-q2k2krnm	1237	4	,	,	,
cord-022353-q2k2krnm	1237	5	thyroglobulin	thyroglobulin	NNP
cord-022353-q2k2krnm	1237	6	is	be	VBZ
cord-022353-q2k2krnm	1237	7	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1237	8	and	and	CC
cord-022353-q2k2krnm	1237	9	stored	store	VBN
cord-022353-q2k2krnm	1237	10	,	,	,
cord-022353-q2k2krnm	1237	11	and	and	CC
cord-022353-q2k2krnm	1237	12	later	later	RB
cord-022353-q2k2krnm	1237	13	hydrolyzed	hydrolyze	VBN
cord-022353-q2k2krnm	1237	14	to	to	TO
cord-022353-q2k2krnm	1237	15	form	form	VB
cord-022353-q2k2krnm	1237	16	T	T	NNP
cord-022353-q2k2krnm	1237	17	4	4	CD
cord-022353-q2k2krnm	1237	18	.	.	.
cord-022353-q2k2krnm	1238	1	The	the	DT
cord-022353-q2k2krnm	1238	2	tyrosine	tyrosine	NN
cord-022353-q2k2krnm	1238	3	residues	residue	NNS
cord-022353-q2k2krnm	1238	4	,	,	,
cord-022353-q2k2krnm	1238	5	held	hold	VBN
cord-022353-q2k2krnm	1238	6	in	in	IN
cord-022353-q2k2krnm	1238	7	peptide	peptide	NN
cord-022353-q2k2krnm	1238	8	linkage	linkage	NN
cord-022353-q2k2krnm	1238	9	within	within	IN
cord-022353-q2k2krnm	1238	10	thyroglobulin	thyroglobulin	NNP
cord-022353-q2k2krnm	1238	11	,	,	,
cord-022353-q2k2krnm	1238	12	are	be	VBP
cord-022353-q2k2krnm	1238	13	first	first	RB
cord-022353-q2k2krnm	1238	14	iodinated	iodinate	VBN
cord-022353-q2k2krnm	1238	15	and	and	CC
cord-022353-q2k2krnm	1238	16	later	later	JJ
cord-022353-q2k2krnm	1238	17	iodotyrosines	iodotyrosine	NNS
cord-022353-q2k2krnm	1238	18	are	be	VBP
cord-022353-q2k2krnm	1238	19	chemically	chemically	RB
cord-022353-q2k2krnm	1238	20	coupled	couple	VBN
cord-022353-q2k2krnm	1238	21	to	to	TO
cord-022353-q2k2krnm	1238	22	form	form	VB
cord-022353-q2k2krnm	1238	23	hormonally	hormonally	RB
cord-022353-q2k2krnm	1238	24	active	active	JJ
cord-022353-q2k2krnm	1238	25	T	T	NNP
cord-022353-q2k2krnm	1238	26	4	4	CD
cord-022353-q2k2krnm	1238	27	and	and	CC
cord-022353-q2k2krnm	1238	28	T	T	NNP
cord-022353-q2k2krnm	1238	29	3	3	CD
cord-022353-q2k2krnm	1238	30	.	.	.
cord-022353-q2k2krnm	1239	1	Production	production	NN
cord-022353-q2k2krnm	1239	2	of	of	IN
cord-022353-q2k2krnm	1239	3	T	T	NNP
cord-022353-q2k2krnm	1239	4	4	4	CD
cord-022353-q2k2krnm	1239	5	depends	depend	VBZ
cord-022353-q2k2krnm	1239	6	on	on	IN
cord-022353-q2k2krnm	1239	7	adequate	adequate	JJ
cord-022353-q2k2krnm	1239	8	supplies	supply	NNS
cord-022353-q2k2krnm	1239	9	of	of	IN
cord-022353-q2k2krnm	1239	10	iodine	iodine	NN
cord-022353-q2k2krnm	1239	11	.	.	.
cord-022353-q2k2krnm	1240	1	Both	both	CC
cord-022353-q2k2krnm	1240	2	T	T	NNP
cord-022353-q2k2krnm	1240	3	3	3	CD
cord-022353-q2k2krnm	1240	4	and	and	CC
cord-022353-q2k2krnm	1240	5	T	T	NNP
cord-022353-q2k2krnm	1240	6	4	4	CD
cord-022353-q2k2krnm	1240	7	circulate	circulate	VBP
cord-022353-q2k2krnm	1240	8	in	in	IN
cord-022353-q2k2krnm	1240	9	the	the	DT
cord-022353-q2k2krnm	1240	10	blood	blood	NN
cord-022353-q2k2krnm	1240	11	primarily	primarily	RB
cord-022353-q2k2krnm	1240	12	bound	bind	VBN
cord-022353-q2k2krnm	1240	13	to	to	IN
cord-022353-q2k2krnm	1240	14	albumin	albumin	NN
cord-022353-q2k2krnm	1240	15	and	and	CC
cord-022353-q2k2krnm	1240	16	m	m	NN
cord-022353-q2k2krnm	1240	17	-	-	NN
cord-022353-q2k2krnm	1240	18	globulin	globulin	NN
cord-022353-q2k2krnm	1240	19	;	;	:
cord-022353-q2k2krnm	1240	20	however	however	RB
cord-022353-q2k2krnm	1240	21	,	,	,
cord-022353-q2k2krnm	1240	22	mouse	mouse	NNP
cord-022353-q2k2krnm	1240	23	transthyretin	transthyretin	NNP
cord-022353-q2k2krnm	1240	24	does	do	VBZ
cord-022353-q2k2krnm	1240	25	not	not	RB
cord-022353-q2k2krnm	1240	26	bind	bind	VB
cord-022353-q2k2krnm	1240	27	T	T	NNP
cord-022353-q2k2krnm	1240	28	4	4	CD
cord-022353-q2k2krnm	1240	29	.	.	.
cord-022353-q2k2krnm	1241	1	Approximately	approximately	RB
cord-022353-q2k2krnm	1241	2	85	85	CD
cord-022353-q2k2krnm	1241	3	%	%	NN
cord-022353-q2k2krnm	1241	4	of	of	IN
cord-022353-q2k2krnm	1241	5	T3	T3	NNP
cord-022353-q2k2krnm	1241	6	,	,	,
cord-022353-q2k2krnm	1241	7	the	the	DT
cord-022353-q2k2krnm	1241	8	active	active	JJ
cord-022353-q2k2krnm	1241	9	thyroid	thyroid	NN
cord-022353-q2k2krnm	1241	10	hormone	hormone	NN
cord-022353-q2k2krnm	1241	11	,	,	,
cord-022353-q2k2krnm	1241	12	in	in	IN
cord-022353-q2k2krnm	1241	13	blood	blood	NN
cord-022353-q2k2krnm	1241	14	is	be	VBZ
cord-022353-q2k2krnm	1241	15	made	make	VBN
cord-022353-q2k2krnm	1241	16	through	through	IN
cord-022353-q2k2krnm	1241	17	the	the	DT
cord-022353-q2k2krnm	1241	18	monodeiodination	monodeiodination	NN
cord-022353-q2k2krnm	1241	19	of	of	IN
cord-022353-q2k2krnm	1241	20	the	the	DT
cord-022353-q2k2krnm	1241	21	outer	outer	JJ
cord-022353-q2k2krnm	1241	22	ring	ring	NN
cord-022353-q2k2krnm	1241	23	of	of	IN
cord-022353-q2k2krnm	1241	24	T	T	NNP
cord-022353-q2k2krnm	1241	25	4	4	CD
cord-022353-q2k2krnm	1241	26	in	in	IN
cord-022353-q2k2krnm	1241	27	a	a	DT
cord-022353-q2k2krnm	1241	28	variety	variety	NN
cord-022353-q2k2krnm	1241	29	of	of	IN
cord-022353-q2k2krnm	1241	30	tissues	tissue	NNS
cord-022353-q2k2krnm	1241	31	.	.	.
cord-022353-q2k2krnm	1242	1	Certain	certain	JJ
cord-022353-q2k2krnm	1242	2	drugs	drug	NNS
cord-022353-q2k2krnm	1242	3	,	,	,
cord-022353-q2k2krnm	1242	4	food	food	NN
cord-022353-q2k2krnm	1242	5	deprivation	deprivation	NN
cord-022353-q2k2krnm	1242	6	,	,	,
cord-022353-q2k2krnm	1242	7	and	and	CC
cord-022353-q2k2krnm	1242	8	illness	illness	NN
cord-022353-q2k2krnm	1242	9	can	can	MD
cord-022353-q2k2krnm	1242	10	all	all	DT
cord-022353-q2k2krnm	1242	11	effect	effect	VB
cord-022353-q2k2krnm	1242	12	monodeiodinase	monodeiodinase	NN
cord-022353-q2k2krnm	1242	13	activity	activity	NN
cord-022353-q2k2krnm	1242	14	(	(	-LRB-
cord-022353-q2k2krnm	1242	15	Reimers	Reimers	NNPS
cord-022353-q2k2krnm	1242	16	1999	1999	CD
cord-022353-q2k2krnm	1242	17	)	)	-RRB-
cord-022353-q2k2krnm	1242	18	.	.	.
cord-022353-q2k2krnm	1243	1	T3	T3	NNP
cord-022353-q2k2krnm	1243	2	actions	action	NNS
cord-022353-q2k2krnm	1243	3	are	be	VBP
cord-022353-q2k2krnm	1243	4	mediated	mediate	VBN
cord-022353-q2k2krnm	1243	5	via	via	IN
cord-022353-q2k2krnm	1243	6	two	two	CD
cord-022353-q2k2krnm	1243	7	T3	T3	NNP
cord-022353-q2k2krnm	1243	8	receptors	receptor	NNS
cord-022353-q2k2krnm	1243	9	,	,	,
cord-022353-q2k2krnm	1243	10	TR~	TR~	NNP
cord-022353-q2k2krnm	1244	1	x	x	NN
cord-022353-q2k2krnm	1244	2	and	and	CC
cord-022353-q2k2krnm	1244	3	TR[3	TR[3	NNP
cord-022353-q2k2krnm	1244	4	,	,	,
cord-022353-q2k2krnm	1244	5	which	which	WDT
cord-022353-q2k2krnm	1244	6	act	act	VBP
cord-022353-q2k2krnm	1244	7	as	as	IN
cord-022353-q2k2krnm	1244	8	hormone	hormone	NN
cord-022353-q2k2krnm	1244	9	-	-	HYPH
cord-022353-q2k2krnm	1244	10	inducible	inducible	JJ
cord-022353-q2k2krnm	1244	11	transcription	transcription	NN
cord-022353-q2k2krnm	1244	12	factors	factor	NNS
cord-022353-q2k2krnm	1244	13	and	and	CC
cord-022353-q2k2krnm	1244	14	belong	belong	VBP
cord-022353-q2k2krnm	1244	15	to	to	IN
cord-022353-q2k2krnm	1244	16	a	a	DT
cord-022353-q2k2krnm	1244	17	large	large	JJ
cord-022353-q2k2krnm	1244	18	superfamily	superfamily	NN
cord-022353-q2k2krnm	1244	19	of	of	IN
cord-022353-q2k2krnm	1244	20	nuclear	nuclear	JJ
cord-022353-q2k2krnm	1244	21	hormone	hormone	NN
cord-022353-q2k2krnm	1244	22	receptors	receptor	NNS
cord-022353-q2k2krnm	1244	23	including	include	VBG
cord-022353-q2k2krnm	1244	24	the	the	DT
cord-022353-q2k2krnm	1244	25	steroid	steroid	NN
cord-022353-q2k2krnm	1244	26	hormone	hormone	NN
cord-022353-q2k2krnm	1244	27	,	,	,
cord-022353-q2k2krnm	1244	28	vitamin	vitamin	NN
cord-022353-q2k2krnm	1244	29	D	d	NN
cord-022353-q2k2krnm	1244	30	,	,	,
cord-022353-q2k2krnm	1244	31	retinoic	retinoic	JJ
cord-022353-q2k2krnm	1244	32	acid	acid	NN
cord-022353-q2k2krnm	1244	33	,	,	,
cord-022353-q2k2krnm	1244	34	and	and	CC
cord-022353-q2k2krnm	1244	35	peroxisomal	peroxisomal	JJ
cord-022353-q2k2krnm	1244	36	proliferator	proliferator	NN
cord-022353-q2k2krnm	1244	37	receptors	receptor	NNS
cord-022353-q2k2krnm	1244	38	(	(	-LRB-
cord-022353-q2k2krnm	1244	39	Yen	Yen	NNP
cord-022353-q2k2krnm	1244	40	2003	2003	CD
cord-022353-q2k2krnm	1244	41	)	)	-RRB-
cord-022353-q2k2krnm	1244	42	.	.	.
cord-022353-q2k2krnm	1245	1	In	in	IN
cord-022353-q2k2krnm	1245	2	mouse	mouse	NN
cord-022353-q2k2krnm	1245	3	and	and	CC
cord-022353-q2k2krnm	1245	4	human	human	JJ
cord-022353-q2k2krnm	1245	5	TR~	TR~	NNP
cord-022353-q2k2krnm	1245	6	and	and	CC
cord-022353-q2k2krnm	1245	7	TR[3	TR[3	NNP
cord-022353-q2k2krnm	1245	8	encode	encode	VB
cord-022353-q2k2krnm	1245	9	nine	nine	CD
cord-022353-q2k2krnm	1245	10	mRNA	mrna	NN
cord-022353-q2k2krnm	1245	11	isoforms	isoform	NNS
cord-022353-q2k2krnm	1245	12	through	through	IN
cord-022353-q2k2krnm	1245	13	alternative	alternative	JJ
cord-022353-q2k2krnm	1245	14	splicing	splicing	NN
cord-022353-q2k2krnm	1245	15	;	;	:
cord-022353-q2k2krnm	1245	16	four	four	CD
cord-022353-q2k2krnm	1245	17	isoforms	isoform	NNS
cord-022353-q2k2krnm	1245	18	TR	tr	NN
cord-022353-q2k2krnm	1245	19	~	~	NFP
cord-022353-q2k2krnm	1245	20	I	-PRON-	PRP
cord-022353-q2k2krnm	1245	21	,	,	,
cord-022353-q2k2krnm	1245	22	TRc~2	TRc~2	NNP
cord-022353-q2k2krnm	1245	23	,	,	,
cord-022353-q2k2krnm	1245	24	TR[31	TR[31	NNP
cord-022353-q2k2krnm	1245	25	,	,	,
cord-022353-q2k2krnm	1245	26	and	and	CC
cord-022353-q2k2krnm	1245	27	TRI]2	TRI]2	NNP
cord-022353-q2k2krnm	1245	28	,	,	,
cord-022353-q2k2krnm	1245	29	are	be	VBP
cord-022353-q2k2krnm	1245	30	expressed	express	VBN
cord-022353-q2k2krnm	1245	31	as	as	IN
cord-022353-q2k2krnm	1245	32	proteins	protein	NNS
cord-022353-q2k2krnm	1245	33	.	.	.
cord-022353-q2k2krnm	1246	1	TRc~	TRc~	NNP
cord-022353-q2k2krnm	1246	2	~	~	NNP
cord-022353-q2k2krnm	1246	3	KO	KO	NNP
cord-022353-q2k2krnm	1246	4	mice	mouse	NNS
cord-022353-q2k2krnm	1246	5	,	,	,
cord-022353-q2k2krnm	1246	6	which	which	WDT
cord-022353-q2k2krnm	1246	7	lack	lack	VBP
cord-022353-q2k2krnm	1246	8	all	all	DT
cord-022353-q2k2krnm	1246	9	products	product	NNS
cord-022353-q2k2krnm	1246	10	from	from	IN
cord-022353-q2k2krnm	1246	11	the	the	DT
cord-022353-q2k2krnm	1246	12	TR~	TR~	NNP
cord-022353-q2k2krnm	1246	13	locus	locus	NN
cord-022353-q2k2krnm	1246	14	,	,	,
cord-022353-q2k2krnm	1246	15	are	be	VBP
cord-022353-q2k2krnm	1246	16	fertile	fertile	JJ
cord-022353-q2k2krnm	1246	17	and	and	CC
cord-022353-q2k2krnm	1246	18	have	have	VBP
cord-022353-q2k2krnm	1246	19	normal	normal	JJ
cord-022353-q2k2krnm	1246	20	basal	basal	JJ
cord-022353-q2k2krnm	1246	21	thyroid	thyroid	NN
cord-022353-q2k2krnm	1246	22	status	status	NN
cord-022353-q2k2krnm	1246	23	but	but	CC
cord-022353-q2k2krnm	1246	24	have	have	VBP
cord-022353-q2k2krnm	1246	25	increased	increase	VBN
cord-022353-q2k2krnm	1246	26	sensitivity	sensitivity	NN
cord-022353-q2k2krnm	1246	27	to	to	IN
cord-022353-q2k2krnm	1246	28	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1246	29	hormones	hormone	NNS
cord-022353-q2k2krnm	1246	30	in	in	IN
cord-022353-q2k2krnm	1246	31	the	the	DT
cord-022353-q2k2krnm	1246	32	pituitary	pituitary	NN
cord-022353-q2k2krnm	1246	33	and	and	CC
cord-022353-q2k2krnm	1246	34	liver	liver	NN
cord-022353-q2k2krnm	1246	35	following	follow	VBG
cord-022353-q2k2krnm	1246	36	provocative	provocative	JJ
cord-022353-q2k2krnm	1246	37	testing	testing	NN
cord-022353-q2k2krnm	1246	38	with	with	IN
cord-022353-q2k2krnm	1246	39	increasing	increase	VBG
cord-022353-q2k2krnm	1246	40	doses	dose	NNS
cord-022353-q2k2krnm	1246	41	of	of	IN
cord-022353-q2k2krnm	1246	42	T3	T3	NNP
cord-022353-q2k2krnm	1246	43	.	.	.
cord-022353-q2k2krnm	1247	1	TR	TR	NNP
cord-022353-q2k2krnm	1248	1	~x	~x	NNP
cord-022353-q2k2krnm	1248	2	-/-have	-/-have	:
cord-022353-q2k2krnm	1248	3	a	a	DT
cord-022353-q2k2krnm	1248	4	disruption	disruption	NN
cord-022353-q2k2krnm	1248	5	of	of	IN
cord-022353-q2k2krnm	1248	6	the	the	DT
cord-022353-q2k2krnm	1248	7	first	first	JJ
cord-022353-q2k2krnm	1248	8	coding	coding	NN
cord-022353-q2k2krnm	1248	9	exon	exon	NN
cord-022353-q2k2krnm	1248	10	in	in	IN
cord-022353-q2k2krnm	1248	11	the	the	DT
cord-022353-q2k2krnm	1248	12	TR	tr	NN
cord-022353-q2k2krnm	1248	13	~	~	NFP
cord-022353-q2k2krnm	1248	14	x	x	NN
cord-022353-q2k2krnm	1248	15	locus	locus	NN
cord-022353-q2k2krnm	1248	16	,	,	,
cord-022353-q2k2krnm	1248	17	which	which	WDT
cord-022353-q2k2krnm	1248	18	prevents	prevent	VBZ
cord-022353-q2k2krnm	1248	19	transcription	transcription	NN
cord-022353-q2k2krnm	1248	20	of	of	IN
cord-022353-q2k2krnm	1248	21	TR	TR	NNP
cord-022353-q2k2krnm	1248	22	~	~	NFP
cord-022353-q2k2krnm	1248	23	I	I	NNP
cord-022353-q2k2krnm	1248	24	and	and	CC
cord-022353-q2k2krnm	1248	25	TRy2	TRy2	NNP
cord-022353-q2k2krnm	1249	1	mRNAs	mRNAs	.
cord-022353-q2k2krnm	1250	1	but	but	CC
cord-022353-q2k2krnm	1250	2	not	not	RB
cord-022353-q2k2krnm	1250	3	TRA	TRA	NNP
cord-022353-q2k2krnm	1250	4	~	~	NFP
cord-022353-q2k2krnm	1250	5	I	i	NN
cord-022353-q2k2krnm	1250	6	or	or	CC
cord-022353-q2k2krnm	1250	7	TRA~2	TRA~2	NNP
cord-022353-q2k2krnm	1250	8	.	.	.
cord-022353-q2k2krnm	1251	1	These	these	DT
cord-022353-q2k2krnm	1251	2	pups	pup	NNS
cord-022353-q2k2krnm	1251	3	die	die	VBP
cord-022353-q2k2krnm	1251	4	shortly	shortly	RB
cord-022353-q2k2krnm	1251	5	after	after	IN
cord-022353-q2k2krnm	1251	6	weaning	wean	VBG
cord-022353-q2k2krnm	1251	7	unless	unless	IN
cord-022353-q2k2krnm	1251	8	supplemented	supplement	VBN
cord-022353-q2k2krnm	1251	9	with	with	IN
cord-022353-q2k2krnm	1251	10	T3	T3	NNP
cord-022353-q2k2krnm	1251	11	for	for	IN
cord-022353-q2k2krnm	1251	12	the	the	DT
cord-022353-q2k2krnm	1251	13	first	first	JJ
cord-022353-q2k2krnm	1251	14	2.5	2.5	CD
cord-022353-q2k2krnm	1251	15	months	month	NNS
cord-022353-q2k2krnm	1251	16	of	of	IN
cord-022353-q2k2krnm	1251	17	life	life	NN
cord-022353-q2k2krnm	1251	18	,	,	,
cord-022353-q2k2krnm	1251	19	after	after	IN
cord-022353-q2k2krnm	1251	20	which	which	WDT
cord-022353-q2k2krnm	1251	21	they	-PRON-	PRP
cord-022353-q2k2krnm	1251	22	develop	develop	VBP
cord-022353-q2k2krnm	1251	23	normal	normal	JJ
cord-022353-q2k2krnm	1251	24	thyroxine	thyroxine	JJ
cord-022353-q2k2krnm	1251	25	levels	level	NNS
cord-022353-q2k2krnm	1251	26	.	.	.
cord-022353-q2k2krnm	1252	1	However	however	RB
cord-022353-q2k2krnm	1252	2	,	,	,
cord-022353-q2k2krnm	1252	3	both	both	DT
cord-022353-q2k2krnm	1252	4	genders	gender	NNS
cord-022353-q2k2krnm	1252	5	are	be	VBP
cord-022353-q2k2krnm	1252	6	infertile	infertile	JJ
cord-022353-q2k2krnm	1252	7	.	.	.
cord-022353-q2k2krnm	1253	1	TRy2	try2	NN
cord-022353-q2k2krnm	1253	2	-/-overexpresses	-/-overexpresses	:
cord-022353-q2k2krnm	1253	3	TR	TR	NNP
cord-022353-q2k2krnm	1253	4	~	~	NFP
cord-022353-q2k2krnm	1253	5	I	-PRON-	PRP
cord-022353-q2k2krnm	1253	6	and	and	CC
cord-022353-q2k2krnm	1253	7	are	be	VBP
cord-022353-q2k2krnm	1253	8	hypothyroid	hypothyroid	JJ
cord-022353-q2k2krnm	1253	9	but	but	CC
cord-022353-q2k2krnm	1253	10	have	have	VBP
cord-022353-q2k2krnm	1253	11	inappropriately	inappropriately	RB
cord-022353-q2k2krnm	1253	12	normal	normal	JJ
cord-022353-q2k2krnm	1253	13	TSH	TSH	NNP
cord-022353-q2k2krnm	1253	14	levels	level	NNS
cord-022353-q2k2krnm	1253	15	.	.	.
cord-022353-q2k2krnm	1254	1	They	-PRON-	PRP
cord-022353-q2k2krnm	1254	2	exhibit	exhibit	VBP
cord-022353-q2k2krnm	1254	3	some	some	DT
cord-022353-q2k2krnm	1254	4	signs	sign	NNS
cord-022353-q2k2krnm	1254	5	of	of	IN
cord-022353-q2k2krnm	1254	6	hyperthyroidism	hyperthyroidism	NN
cord-022353-q2k2krnm	1254	7	,	,	,
cord-022353-q2k2krnm	1254	8	such	such	JJ
cord-022353-q2k2krnm	1254	9	as	as	IN
cord-022353-q2k2krnm	1254	10	increased	increase	VBN
cord-022353-q2k2krnm	1254	11	heart	heart	NN
cord-022353-q2k2krnm	1254	12	rate	rate	NN
cord-022353-q2k2krnm	1254	13	,	,	,
cord-022353-q2k2krnm	1254	14	weight	weight	NN
cord-022353-q2k2krnm	1254	15	loss	loss	NN
cord-022353-q2k2krnm	1254	16	,	,	,
cord-022353-q2k2krnm	1254	17	and	and	CC
cord-022353-q2k2krnm	1254	18	elevated	elevated	JJ
cord-022353-q2k2krnm	1254	19	body	body	NN
cord-022353-q2k2krnm	1254	20	temperature	temperature	NN
cord-022353-q2k2krnm	1254	21	.	.	.
cord-022353-q2k2krnm	1255	1	TR~	TR~	NNP
cord-022353-q2k2krnm	1256	1	-/-lack	-/-lack	NFP
cord-022353-q2k2krnm	1256	2	all	all	DT
cord-022353-q2k2krnm	1257	1	TR[3	TR[3	NNP
cord-022353-q2k2krnm	1257	2	isoforms	isoform	NNS
cord-022353-q2k2krnm	1257	3	and	and	CC
cord-022353-q2k2krnm	1257	4	display	display	NN
cord-022353-q2k2krnm	1257	5	resistance	resistance	NN
cord-022353-q2k2krnm	1257	6	to	to	IN
cord-022353-q2k2krnm	1257	7	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1257	8	hormones	hormone	NNS
cord-022353-q2k2krnm	1257	9	demonstrating	demonstrate	VBG
cord-022353-q2k2krnm	1257	10	the	the	DT
cord-022353-q2k2krnm	1257	11	key	key	JJ
cord-022353-q2k2krnm	1257	12	role	role	NN
cord-022353-q2k2krnm	1257	13	of	of	IN
cord-022353-q2k2krnm	1257	14	TR~	TR~	NNP
cord-022353-q2k2krnm	1257	15	in	in	IN
cord-022353-q2k2krnm	1257	16	set	set	NN
cord-022353-q2k2krnm	1257	17	-	-	HYPH
cord-022353-q2k2krnm	1257	18	point	point	NN
cord-022353-q2k2krnm	1257	19	control	control	NN
cord-022353-q2k2krnm	1257	20	of	of	IN
cord-022353-q2k2krnm	1257	21	the	the	DT
cord-022353-q2k2krnm	1257	22	pituitary	pituitary	JJ
cord-022353-q2k2krnm	1257	23	-	-	HYPH
cord-022353-q2k2krnm	1257	24	thyroid	thyroid	NN
cord-022353-q2k2krnm	1257	25	feedback	feedback	NN
cord-022353-q2k2krnm	1257	26	axis	axis	NN
cord-022353-q2k2krnm	1257	27	.	.	.
cord-022353-q2k2krnm	1258	1	TR[32	TR[32	NNP
cord-022353-q2k2krnm	1258	2	-/-KO	-/-ko	CD
cord-022353-q2k2krnm	1258	3	mice	mouse	NNS
cord-022353-q2k2krnm	1258	4	have	have	VBP
cord-022353-q2k2krnm	1258	5	resistance	resistance	NN
cord-022353-q2k2krnm	1258	6	to	to	IN
cord-022353-q2k2krnm	1258	7	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1258	8	hormones	hormone	NNS
cord-022353-q2k2krnm	1258	9	and	and	CC
cord-022353-q2k2krnm	1258	10	elevated	elevate	VBN
cord-022353-q2k2krnm	1258	11	T3	T3	NNP
cord-022353-q2k2krnm	1258	12	,	,	,
cord-022353-q2k2krnm	1258	13	T4	T4	NNP
cord-022353-q2k2krnm	1258	14	,	,	,
cord-022353-q2k2krnm	1258	15	and	and	CC
cord-022353-q2k2krnm	1258	16	TSH	TSH	NNP
cord-022353-q2k2krnm	1258	17	.	.	.
cord-022353-q2k2krnm	1259	1	They	-PRON-	PRP
cord-022353-q2k2krnm	1259	2	have	have	VBP
cord-022353-q2k2krnm	1259	3	defective	defective	JJ
cord-022353-q2k2krnm	1259	4	TSH	TSH	NNP
cord-022353-q2k2krnm	1259	5	suppression	suppression	NN
cord-022353-q2k2krnm	1259	6	by	by	IN
cord-022353-q2k2krnm	1259	7	T3	T3	NNP
cord-022353-q2k2krnm	1259	8	.	.	.
cord-022353-q2k2krnm	1260	1	Several	several	JJ
cord-022353-q2k2krnm	1260	2	double	double	JJ
cord-022353-q2k2krnm	1260	3	KOs	ko	NNS
cord-022353-q2k2krnm	1260	4	(	(	-LRB-
cord-022353-q2k2krnm	1260	5	both	both	DT
cord-022353-q2k2krnm	1260	6	TR~	TR~	NNP
cord-022353-q2k2krnm	1260	7	and	and	CC
cord-022353-q2k2krnm	1260	8	TRI	TRI	NNP
cord-022353-q2k2krnm	1260	9	]	]	-RRB-
cord-022353-q2k2krnm	1260	10	)	)	-RRB-
cord-022353-q2k2krnm	1260	11	have	have	VBP
cord-022353-q2k2krnm	1260	12	been	be	VBN
cord-022353-q2k2krnm	1260	13	developed	develop	VBN
cord-022353-q2k2krnm	1260	14	with	with	IN
cord-022353-q2k2krnm	1260	15	profound	profound	JJ
cord-022353-q2k2krnm	1260	16	resistance	resistance	NN
cord-022353-q2k2krnm	1260	17	to	to	IN
cord-022353-q2k2krnm	1260	18	T3	T3	NNP
cord-022353-q2k2krnm	1260	19	.	.	.
cord-022353-q2k2krnm	1261	1	These	these	DT
cord-022353-q2k2krnm	1261	2	targeted	target	VBN
cord-022353-q2k2krnm	1261	3	mutants	mutant	NNS
cord-022353-q2k2krnm	1261	4	have	have	VBP
cord-022353-q2k2krnm	1261	5	helped	help	VBN
cord-022353-q2k2krnm	1261	6	to	to	TO
cord-022353-q2k2krnm	1261	7	elucidate	elucidate	VB
cord-022353-q2k2krnm	1261	8	the	the	DT
cord-022353-q2k2krnm	1261	9	full	full	JJ
cord-022353-q2k2krnm	1261	10	function	function	NN
cord-022353-q2k2krnm	1261	11	of	of	IN
cord-022353-q2k2krnm	1261	12	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1261	13	hormones	hormone	NNS
cord-022353-q2k2krnm	1261	14	involving	involve	VBG
cord-022353-q2k2krnm	1261	15	:	:	:
cord-022353-q2k2krnm	1261	16	bone	bone	NN
cord-022353-q2k2krnm	1261	17	formation	formation	NN
cord-022353-q2k2krnm	1261	18	and	and	CC
cord-022353-q2k2krnm	1261	19	mineralization	mineralization	NN
cord-022353-q2k2krnm	1261	20	,	,	,
cord-022353-q2k2krnm	1261	21	abnormal	abnormal	JJ
cord-022353-q2k2krnm	1261	22	development	development	NN
cord-022353-q2k2krnm	1261	23	of	of	IN
cord-022353-q2k2krnm	1261	24	skeletal	skeletal	JJ
cord-022353-q2k2krnm	1261	25	muscle	muscle	NN
cord-022353-q2k2krnm	1261	26	,	,	,
cord-022353-q2k2krnm	1261	27	disrupted	disrupt	VBD
cord-022353-q2k2krnm	1261	28	development	development	NN
cord-022353-q2k2krnm	1261	29	of	of	IN
cord-022353-q2k2krnm	1261	30	the	the	DT
cord-022353-q2k2krnm	1261	31	cones	cone	NNS
cord-022353-q2k2krnm	1261	32	in	in	IN
cord-022353-q2k2krnm	1261	33	the	the	DT
cord-022353-q2k2krnm	1261	34	retina	retina	NN
cord-022353-q2k2krnm	1261	35	,	,	,
cord-022353-q2k2krnm	1261	36	abnormalities	abnormality	NNS
cord-022353-q2k2krnm	1261	37	in	in	IN
cord-022353-q2k2krnm	1261	38	the	the	DT
cord-022353-q2k2krnm	1261	39	auditory	auditory	JJ
cord-022353-q2k2krnm	1261	40	system	system	NN
cord-022353-q2k2krnm	1261	41	,	,	,
cord-022353-q2k2krnm	1261	42	cochlear	cochlear	JJ
cord-022353-q2k2krnm	1261	43	and	and	CC
cord-022353-q2k2krnm	1261	44	vestibular	vestibular	JJ
cord-022353-q2k2krnm	1261	45	structures	structure	NNS
cord-022353-q2k2krnm	1261	46	,	,	,
cord-022353-q2k2krnm	1261	47	delayed	delay	VBD
cord-022353-q2k2krnm	1261	48	small	small	JJ
cord-022353-q2k2krnm	1261	49	intestine	intestine	NN
cord-022353-q2k2krnm	1261	50	development	development	NN
cord-022353-q2k2krnm	1261	51	,	,	,
cord-022353-q2k2krnm	1261	52	impaired	impair	VBN
cord-022353-q2k2krnm	1261	53	thermogenesis	thermogenesis	NN
cord-022353-q2k2krnm	1261	54	,	,	,
cord-022353-q2k2krnm	1261	55	and	and	CC
cord-022353-q2k2krnm	1261	56	altered	alter	VBN
cord-022353-q2k2krnm	1261	57	development	development	NN
cord-022353-q2k2krnm	1261	58	of	of	IN
cord-022353-q2k2krnm	1261	59	the	the	DT
cord-022353-q2k2krnm	1261	60	central	central	JJ
cord-022353-q2k2krnm	1261	61	nervous	nervous	JJ
cord-022353-q2k2krnm	1261	62	system	system	NN
cord-022353-q2k2krnm	1261	63	and	and	CC
cord-022353-q2k2krnm	1261	64	immune	immune	JJ
cord-022353-q2k2krnm	1261	65	system	system	NN
cord-022353-q2k2krnm	1261	66	(	(	-LRB-
cord-022353-q2k2krnm	1261	67	O'Shea	O'Shea	NNP
cord-022353-q2k2krnm	1261	68	and	and	CC
cord-022353-q2k2krnm	1261	69	Williams	Williams	NNP
cord-022353-q2k2krnm	1261	70	2002	2002	CD
cord-022353-q2k2krnm	1261	71	)	)	-RRB-
cord-022353-q2k2krnm	1261	72	.	.	.
cord-022353-q2k2krnm	1262	1	Both	both	DT
cord-022353-q2k2krnm	1262	2	total	total	JJ
cord-022353-q2k2krnm	1262	3	T	T	NNP
cord-022353-q2k2krnm	1262	4	4	4	CD
cord-022353-q2k2krnm	1262	5	and	and	CC
cord-022353-q2k2krnm	1262	6	T3	T3	NNP
cord-022353-q2k2krnm	1262	7	can	can	MD
cord-022353-q2k2krnm	1262	8	be	be	VB
cord-022353-q2k2krnm	1262	9	measured	measure	VBN
cord-022353-q2k2krnm	1262	10	by	by	IN
cord-022353-q2k2krnm	1262	11	RIA	RIA	NNP
cord-022353-q2k2krnm	1262	12	in	in	IN
cord-022353-q2k2krnm	1262	13	mice	mouse	NNS
cord-022353-q2k2krnm	1262	14	,	,	,
cord-022353-q2k2krnm	1262	15	and	and	CC
cord-022353-q2k2krnm	1262	16	reference	reference	NN
cord-022353-q2k2krnm	1262	17	ranges	range	NNS
cord-022353-q2k2krnm	1262	18	vary	vary	VBP
cord-022353-q2k2krnm	1262	19	greatly	greatly	RB
cord-022353-q2k2krnm	1262	20	by	by	IN
cord-022353-q2k2krnm	1262	21	strain	strain	NN
cord-022353-q2k2krnm	1262	22	and	and	CC
cord-022353-q2k2krnm	1262	23	age	age	NN
cord-022353-q2k2krnm	1262	24	.	.	.
cord-022353-q2k2krnm	1263	1	Although	although	IN
cord-022353-q2k2krnm	1263	2	T3	T3	NNP
cord-022353-q2k2krnm	1263	3	is	be	VBZ
cord-022353-q2k2krnm	1263	4	the	the	DT
cord-022353-q2k2krnm	1263	5	active	active	JJ
cord-022353-q2k2krnm	1263	6	hormone	hormone	NN
cord-022353-q2k2krnm	1263	7	,	,	,
cord-022353-q2k2krnm	1263	8	its	-PRON-	PRP$
cord-022353-q2k2krnm	1263	9	serum	serum	NN
cord-022353-q2k2krnm	1263	10	levels	level	NNS
cord-022353-q2k2krnm	1263	11	are	be	VBP
cord-022353-q2k2krnm	1263	12	so	so	RB
cord-022353-q2k2krnm	1263	13	low	low	JJ
cord-022353-q2k2krnm	1263	14	that	that	IN
cord-022353-q2k2krnm	1263	15	it	-PRON-	PRP
cord-022353-q2k2krnm	1263	16	is	be	VBZ
cord-022353-q2k2krnm	1263	17	a	a	DT
cord-022353-q2k2krnm	1263	18	less	less	RBR
cord-022353-q2k2krnm	1263	19	reliable	reliable	JJ
cord-022353-q2k2krnm	1263	20	indicator	indicator	NN
cord-022353-q2k2krnm	1263	21	of	of	IN
cord-022353-q2k2krnm	1263	22	thyroid	thyroid	NN
cord-022353-q2k2krnm	1263	23	status	status	NN
cord-022353-q2k2krnm	1263	24	.	.	.
cord-022353-q2k2krnm	1264	1	Total	total	JJ
cord-022353-q2k2krnm	1264	2	T	T	NNP
cord-022353-q2k2krnm	1264	3	4	4	CD
cord-022353-q2k2krnm	1264	4	ranges	range	NNS
cord-022353-q2k2krnm	1264	5	in	in	IN
cord-022353-q2k2krnm	1264	6	Swiss	Swiss	NNP
cord-022353-q2k2krnm	1264	7	Webster	Webster	NNP
cord-022353-q2k2krnm	1264	8	and	and	CC
cord-022353-q2k2krnm	1264	9	ICR	ICR	NNP
cord-022353-q2k2krnm	1264	10	mice	mouse	NNS
cord-022353-q2k2krnm	1264	11	are	be	VBP
cord-022353-q2k2krnm	1264	12	5.5	5.5	CD
cord-022353-q2k2krnm	1264	13	_	_	NN
cord-022353-q2k2krnm	1264	14	+	+	CC
cord-022353-q2k2krnm	1265	1	0.7	0.7	CD
cord-022353-q2k2krnm	1265	2	and	and	CC
cord-022353-q2k2krnm	1265	3	4.7	4.7	CD
cord-022353-q2k2krnm	1265	4	+	+	SYM
cord-022353-q2k2krnm	1265	5	0.3	0.3	CD
cord-022353-q2k2krnm	1265	6	jag	jag	NNP
cord-022353-q2k2krnm	1265	7	/	/	SYM
cord-022353-q2k2krnm	1265	8	ml	ml	XX
cord-022353-q2k2krnm	1265	9	,	,	,
cord-022353-q2k2krnm	1265	10	respectively	respectively	RB
cord-022353-q2k2krnm	1265	11	.	.	.
cord-022353-q2k2krnm	1266	1	Total	total	JJ
cord-022353-q2k2krnm	1266	2	T3	T3	NNP
cord-022353-q2k2krnm	1266	3	levels	level	NNS
cord-022353-q2k2krnm	1266	4	range	range	VBP
cord-022353-q2k2krnm	1266	5	from	from	IN
cord-022353-q2k2krnm	1266	6	65	65	CD
cord-022353-q2k2krnm	1266	7	-	-	SYM
cord-022353-q2k2krnm	1266	8	85	85	CD
cord-022353-q2k2krnm	1266	9	ng/100	ng/100	NNS
cord-022353-q2k2krnm	1266	10	ml	ml	NN
cord-022353-q2k2krnm	1266	11	in	in	IN
cord-022353-q2k2krnm	1266	12	both	both	DT
cord-022353-q2k2krnm	1266	13	SW	SW	NNP
cord-022353-q2k2krnm	1266	14	and	and	CC
cord-022353-q2k2krnm	1266	15	ICR	ICR	NNP
cord-022353-q2k2krnm	1266	16	stocks	stock	NNS
cord-022353-q2k2krnm	1266	17	(	(	-LRB-
cord-022353-q2k2krnm	1266	18	DePaolo	DePaolo	NNP
cord-022353-q2k2krnm	1266	19	and	and	CC
cord-022353-q2k2krnm	1266	20	Masoro	Masoro	NNP
cord-022353-q2k2krnm	1266	21	1989	1989	CD
cord-022353-q2k2krnm	1266	22	)	)	-RRB-
cord-022353-q2k2krnm	1266	23	.	.	.
cord-022353-q2k2krnm	1267	1	Many	many	JJ
cord-022353-q2k2krnm	1267	2	factors	factor	NNS
cord-022353-q2k2krnm	1267	3	,	,	,
cord-022353-q2k2krnm	1267	4	including	include	VBG
cord-022353-q2k2krnm	1267	5	autoantibodies	autoantibody	NNS
cord-022353-q2k2krnm	1267	6	,	,	,
cord-022353-q2k2krnm	1267	7	are	be	VBP
cord-022353-q2k2krnm	1267	8	known	know	VBN
cord-022353-q2k2krnm	1267	9	to	to	TO
cord-022353-q2k2krnm	1267	10	interfere	interfere	VB
cord-022353-q2k2krnm	1267	11	with	with	IN
cord-022353-q2k2krnm	1267	12	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1267	13	hormone	hormone	NN
cord-022353-q2k2krnm	1267	14	assays	assay	NNS
cord-022353-q2k2krnm	1267	15	(	(	-LRB-
cord-022353-q2k2krnm	1267	16	Despres	Despres	NNPS
cord-022353-q2k2krnm	1267	17	and	and	CC
cord-022353-q2k2krnm	1267	18	Grant	Grant	NNP
cord-022353-q2k2krnm	1267	19	1998	1998	CD
cord-022353-q2k2krnm	1267	20	;	;	:
cord-022353-q2k2krnm	1267	21	Reimers	Reimers	NNPS
cord-022353-q2k2krnm	1267	22	1999	1999	CD
cord-022353-q2k2krnm	1267	23	)	)	-RRB-
cord-022353-q2k2krnm	1267	24	.	.	.
cord-022353-q2k2krnm	1268	1	12	12	CD
cord-022353-q2k2krnm	1268	2	.	.	.
cord-022353-q2k2krnm	1269	1	Parathyroid	Parathyroid	NNP
cord-022353-q2k2krnm	1269	2	Hormone	Hormone	NNP
cord-022353-q2k2krnm	1269	3	(	(	-LRB-
cord-022353-q2k2krnm	1269	4	PTH	PTH	NNP
cord-022353-q2k2krnm	1269	5	)	)	-RRB-
cord-022353-q2k2krnm	1269	6	PTH	PTH	NNP
cord-022353-q2k2krnm	1269	7	is	be	VBZ
cord-022353-q2k2krnm	1269	8	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1269	9	by	by	IN
cord-022353-q2k2krnm	1269	10	the	the	DT
cord-022353-q2k2krnm	1269	11	chief	chief	JJ
cord-022353-q2k2krnm	1269	12	cells	cell	NNS
cord-022353-q2k2krnm	1269	13	of	of	IN
cord-022353-q2k2krnm	1269	14	the	the	DT
cord-022353-q2k2krnm	1269	15	parathyroid	parathyroid	JJ
cord-022353-q2k2krnm	1269	16	gland	gland	NN
cord-022353-q2k2krnm	1269	17	and	and	CC
cord-022353-q2k2krnm	1269	18	secreted	secrete	VBD
cord-022353-q2k2krnm	1269	19	as	as	IN
cord-022353-q2k2krnm	1269	20	an	an	DT
cord-022353-q2k2krnm	1269	21	84	84	CD
cord-022353-q2k2krnm	1269	22	amino	amino	NN
cord-022353-q2k2krnm	1269	23	acid	acid	NN
cord-022353-q2k2krnm	1269	24	peptide	peptide	NN
cord-022353-q2k2krnm	1269	25	.	.	.
cord-022353-q2k2krnm	1270	1	Circulating	circulate	VBG
cord-022353-q2k2krnm	1270	2	levels	level	NNS
cord-022353-q2k2krnm	1270	3	of	of	IN
cord-022353-q2k2krnm	1270	4	ionized	ionized	JJ
cord-022353-q2k2krnm	1270	5	calcium	calcium	NN
cord-022353-q2k2krnm	1270	6	induce	induce	VBP
cord-022353-q2k2krnm	1270	7	synthesis	synthesis	NN
cord-022353-q2k2krnm	1270	8	of	of	IN
cord-022353-q2k2krnm	1270	9	PTH	PTH	NNP
cord-022353-q2k2krnm	1270	10	.	.	.
cord-022353-q2k2krnm	1271	1	Low	low	JJ
cord-022353-q2k2krnm	1271	2	calcium	calcium	NN
cord-022353-q2k2krnm	1271	3	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	1271	4	PTH	PTH	NNP
cord-022353-q2k2krnm	1271	5	synthesis	synthesis	NN
cord-022353-q2k2krnm	1271	6	,	,	,
cord-022353-q2k2krnm	1271	7	and	and	CC
cord-022353-q2k2krnm	1271	8	high	high	JJ
cord-022353-q2k2krnm	1271	9	calcium	calcium	NN
cord-022353-q2k2krnm	1271	10	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	1271	11	secretion	secretion	NN
cord-022353-q2k2krnm	1271	12	.	.	.
cord-022353-q2k2krnm	1272	1	The	the	DT
cord-022353-q2k2krnm	1272	2	primary	primary	JJ
cord-022353-q2k2krnm	1272	3	function	function	NN
cord-022353-q2k2krnm	1272	4	of	of	IN
cord-022353-q2k2krnm	1272	5	PTH	PTH	NNP
cord-022353-q2k2krnm	1272	6	is	be	VBZ
cord-022353-q2k2krnm	1272	7	to	to	TO
cord-022353-q2k2krnm	1272	8	control	control	VB
cord-022353-q2k2krnm	1272	9	calcium	calcium	NN
cord-022353-q2k2krnm	1272	10	concentrations	concentration	NNS
cord-022353-q2k2krnm	1272	11	in	in	IN
cord-022353-q2k2krnm	1272	12	extracellular	extracellular	JJ
cord-022353-q2k2krnm	1272	13	fluid	fluid	NN
cord-022353-q2k2krnm	1272	14	and	and	CC
cord-022353-q2k2krnm	1272	15	prevent	prevent	VBP
cord-022353-q2k2krnm	1272	16	hypocalcemia	hypocalcemia	NN
cord-022353-q2k2krnm	1272	17	by	by	IN
cord-022353-q2k2krnm	1272	18	increasing	increase	VBG
cord-022353-q2k2krnm	1272	19	calcium	calcium	NN
cord-022353-q2k2krnm	1272	20	resorption	resorption	NN
cord-022353-q2k2krnm	1272	21	from	from	IN
cord-022353-q2k2krnm	1272	22	bone	bone	NN
cord-022353-q2k2krnm	1272	23	,	,	,
cord-022353-q2k2krnm	1272	24	glomerular	glomerular	JJ
cord-022353-q2k2krnm	1272	25	filtrate	filtrate	NN
cord-022353-q2k2krnm	1272	26	,	,	,
cord-022353-q2k2krnm	1272	27	and	and	CC
cord-022353-q2k2krnm	1272	28	intestines	intestine	NNS
cord-022353-q2k2krnm	1272	29	(	(	-LRB-
cord-022353-q2k2krnm	1272	30	Reimers	Reimers	NNPS
cord-022353-q2k2krnm	1272	31	1999	1999	CD
cord-022353-q2k2krnm	1272	32	)	)	-RRB-
cord-022353-q2k2krnm	1272	33	.	.	.
cord-022353-q2k2krnm	1273	1	PTH	PTH	NNP
cord-022353-q2k2krnm	1273	2	mediates	mediate	VBZ
cord-022353-q2k2krnm	1273	3	its	-PRON-	PRP$
cord-022353-q2k2krnm	1273	4	effect	effect	NN
cord-022353-q2k2krnm	1273	5	via	via	IN
cord-022353-q2k2krnm	1273	6	its	-PRON-	PRP$
cord-022353-q2k2krnm	1273	7	G	g	NN
cord-022353-q2k2krnm	1273	8	-	-	HYPH
cord-022353-q2k2krnm	1273	9	protein	protein	NN
cord-022353-q2k2krnm	1273	10	coupled	couple	VBN
cord-022353-q2k2krnm	1273	11	receptor	receptor	NN
cord-022353-q2k2krnm	1273	12	,	,	,
cord-022353-q2k2krnm	1274	1	PTH1R.	pth1r.	NN
cord-022353-q2k2krnm	1274	2	Interestingly	interestingly	RB
cord-022353-q2k2krnm	1275	1	a	a	DT
cord-022353-q2k2krnm	1275	2	second	second	JJ
cord-022353-q2k2krnm	1275	3	protein	protein	NN
cord-022353-q2k2krnm	1275	4	,	,	,
cord-022353-q2k2krnm	1275	5	PTH	PTH	NNP
cord-022353-q2k2krnm	1275	6	related	related	JJ
cord-022353-q2k2krnm	1275	7	protein	protein	NN
cord-022353-q2k2krnm	1275	8	(	(	-LRB-
cord-022353-q2k2krnm	1275	9	PTHrP	PTHrP	NNP
cord-022353-q2k2krnm	1275	10	)	)	-RRB-
cord-022353-q2k2krnm	1275	11	,	,	,
cord-022353-q2k2krnm	1275	12	which	which	WDT
cord-022353-q2k2krnm	1275	13	is	be	VBZ
cord-022353-q2k2krnm	1275	14	secreted	secrete	VBN
cord-022353-q2k2krnm	1275	15	by	by	IN
cord-022353-q2k2krnm	1275	16	a	a	DT
cord-022353-q2k2krnm	1275	17	variety	variety	NN
cord-022353-q2k2krnm	1275	18	of	of	IN
cord-022353-q2k2krnm	1275	19	tissues	tissue	NNS
cord-022353-q2k2krnm	1275	20	and	and	CC
cord-022353-q2k2krnm	1275	21	acts	act	NNS
cord-022353-q2k2krnm	1275	22	by	by	IN
cord-022353-q2k2krnm	1275	23	autocrine	autocrine	NN
cord-022353-q2k2krnm	1275	24	and	and	CC
cord-022353-q2k2krnm	1275	25	paracrine	paracrine	JJ
cord-022353-q2k2krnm	1275	26	signaling	signaling	NN
cord-022353-q2k2krnm	1275	27	,	,	,
cord-022353-q2k2krnm	1275	28	uses	use	VBZ
cord-022353-q2k2krnm	1275	29	the	the	DT
cord-022353-q2k2krnm	1275	30	same	same	JJ
cord-022353-q2k2krnm	1276	1	PTH1R.	pth1r.	NN
cord-022353-q2k2krnm	1277	1	PTHrP	PTHrP	NNP
cord-022353-q2k2krnm	1277	2	modulates	modulate	VBZ
cord-022353-q2k2krnm	1277	3	a	a	DT
cord-022353-q2k2krnm	1277	4	wide	wide	JJ
cord-022353-q2k2krnm	1277	5	range	range	NN
cord-022353-q2k2krnm	1277	6	of	of	IN
cord-022353-q2k2krnm	1277	7	physiologic	physiologic	JJ
cord-022353-q2k2krnm	1277	8	and	and	CC
cord-022353-q2k2krnm	1277	9	developmental	developmental	JJ
cord-022353-q2k2krnm	1277	10	responses	response	NNS
cord-022353-q2k2krnm	1277	11	(	(	-LRB-
cord-022353-q2k2krnm	1277	12	Goltzman	Goltzman	NNP
cord-022353-q2k2krnm	1277	13	and	and	CC
cord-022353-q2k2krnm	1277	14	White	White	NNP
cord-022353-q2k2krnm	1277	15	2000	2000	CD
cord-022353-q2k2krnm	1277	16	)	)	-RRB-
cord-022353-q2k2krnm	1277	17	.	.	.
cord-022353-q2k2krnm	1278	1	Mice	mouse	NNS
cord-022353-q2k2krnm	1278	2	with	with	IN
cord-022353-q2k2krnm	1278	3	targeted	target	VBN
cord-022353-q2k2krnm	1278	4	mutations	mutation	NNS
cord-022353-q2k2krnm	1278	5	of	of	IN
cord-022353-q2k2krnm	1278	6	the	the	DT
cord-022353-q2k2krnm	1278	7	PTH	PTH	NNP
cord-022353-q2k2krnm	1278	8	,	,	,
cord-022353-q2k2krnm	1278	9	PTHrP	PTHrP	NNP
cord-022353-q2k2krnm	1278	10	,	,	,
cord-022353-q2k2krnm	1278	11	and	and	CC
cord-022353-q2k2krnm	1278	12	PTH1R	pth1r	JJ
cord-022353-q2k2krnm	1278	13	genes	gene	NNS
cord-022353-q2k2krnm	1278	14	have	have	VBP
cord-022353-q2k2krnm	1278	15	demonstrated	demonstrate	VBN
cord-022353-q2k2krnm	1278	16	the	the	DT
cord-022353-q2k2krnm	1278	17	critical	critical	JJ
cord-022353-q2k2krnm	1278	18	role	role	NN
cord-022353-q2k2krnm	1278	19	of	of	IN
cord-022353-q2k2krnm	1278	20	these	these	DT
cord-022353-q2k2krnm	1278	21	proteins	protein	NNS
cord-022353-q2k2krnm	1278	22	in	in	IN
cord-022353-q2k2krnm	1278	23	regulating	regulate	VBG
cord-022353-q2k2krnm	1278	24	both	both	CC
cord-022353-q2k2krnm	1278	25	the	the	DT
cord-022353-q2k2krnm	1278	26	switch	switch	NN
cord-022353-q2k2krnm	1278	27	between	between	IN
cord-022353-q2k2krnm	1278	28	proliferation	proliferation	NN
cord-022353-q2k2krnm	1278	29	and	and	CC
cord-022353-q2k2krnm	1278	30	differentiation	differentiation	NN
cord-022353-q2k2krnm	1278	31	of	of	IN
cord-022353-q2k2krnm	1278	32	chondrocytes	chondrocyte	NNS
cord-022353-q2k2krnm	1278	33	and	and	CC
cord-022353-q2k2krnm	1278	34	their	-PRON-	PRP$
cord-022353-q2k2krnm	1278	35	replacement	replacement	NN
cord-022353-q2k2krnm	1278	36	by	by	IN
cord-022353-q2k2krnm	1278	37	bone	bone	NN
cord-022353-q2k2krnm	1278	38	cells	cell	NNS
cord-022353-q2k2krnm	1278	39	(	(	-LRB-
cord-022353-q2k2krnm	1278	40	Schipani	Schipani	NNP
cord-022353-q2k2krnm	1278	41	and	and	CC
cord-022353-q2k2krnm	1278	42	Provost	Provost	NNP
cord-022353-q2k2krnm	1278	43	2003	2003	CD
cord-022353-q2k2krnm	1278	44	)	)	-RRB-
cord-022353-q2k2krnm	1278	45	.	.	.
cord-022353-q2k2krnm	1279	1	Serum	serum	NN
cord-022353-q2k2krnm	1279	2	levels	level	NNS
cord-022353-q2k2krnm	1279	3	of	of	IN
cord-022353-q2k2krnm	1279	4	PTH	PTH	NNP
cord-022353-q2k2krnm	1279	5	may	may	MD
cord-022353-q2k2krnm	1279	6	be	be	VB
cord-022353-q2k2krnm	1279	7	quantified	quantify	VBN
cord-022353-q2k2krnm	1279	8	in	in	IN
cord-022353-q2k2krnm	1279	9	mice	mouse	NNS
cord-022353-q2k2krnm	1279	10	using	use	VBG
cord-022353-q2k2krnm	1279	11	a	a	DT
cord-022353-q2k2krnm	1279	12	commercially	commercially	RB
cord-022353-q2k2krnm	1279	13	available	available	JJ
cord-022353-q2k2krnm	1279	14	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1279	15	kit	kit	NN
cord-022353-q2k2krnm	1279	16	,	,	,
cord-022353-q2k2krnm	1279	17	which	which	WDT
cord-022353-q2k2krnm	1279	18	can	can	MD
cord-022353-q2k2krnm	1279	19	also	also	RB
cord-022353-q2k2krnm	1279	20	be	be	VB
cord-022353-q2k2krnm	1279	21	used	use	VBN
cord-022353-q2k2krnm	1279	22	to	to	TO
cord-022353-q2k2krnm	1279	23	quantify	quantify	VB
cord-022353-q2k2krnm	1279	24	the	the	DT
cord-022353-q2k2krnm	1279	25	protein	protein	NN
cord-022353-q2k2krnm	1279	26	in	in	IN
cord-022353-q2k2krnm	1279	27	rats	rat	NNS
cord-022353-q2k2krnm	1279	28	.	.	.
cord-022353-q2k2krnm	1280	1	13	13	CD
cord-022353-q2k2krnm	1280	2	.	.	.
cord-022353-q2k2krnm	1281	1	Other	other	JJ
cord-022353-q2k2krnm	1281	2	Hormones	hormone	NNS
cord-022353-q2k2krnm	1281	3	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1281	4	kits	kit	NNS
cord-022353-q2k2krnm	1281	5	are	be	VBP
cord-022353-q2k2krnm	1281	6	commercially	commercially	RB
cord-022353-q2k2krnm	1281	7	available	available	JJ
cord-022353-q2k2krnm	1281	8	to	to	TO
cord-022353-q2k2krnm	1281	9	quantify	quantify	VB
cord-022353-q2k2krnm	1281	10	many	many	JJ
cord-022353-q2k2krnm	1281	11	additional	additional	JJ
cord-022353-q2k2krnm	1281	12	hormones	hormone	NNS
cord-022353-q2k2krnm	1281	13	in	in	IN
cord-022353-q2k2krnm	1281	14	the	the	DT
cord-022353-q2k2krnm	1281	15	serum	serum	NN
cord-022353-q2k2krnm	1281	16	of	of	IN
cord-022353-q2k2krnm	1281	17	mice	mouse	NNS
cord-022353-q2k2krnm	1281	18	,	,	,
cord-022353-q2k2krnm	1281	19	including	include	VBG
cord-022353-q2k2krnm	1281	20	insulin	insulin	NN
cord-022353-q2k2krnm	1281	21	,	,	,
cord-022353-q2k2krnm	1281	22	leptin	leptin	NN
cord-022353-q2k2krnm	1281	23	,	,	,
cord-022353-q2k2krnm	1281	24	GH	GH	NNP
cord-022353-q2k2krnm	1281	25	,	,	,
cord-022353-q2k2krnm	1281	26	epinephrine	epinephrine	NN
cord-022353-q2k2krnm	1281	27	,	,	,
cord-022353-q2k2krnm	1281	28	orexin	orexin	NN
cord-022353-q2k2krnm	1281	29	A	a	NN
cord-022353-q2k2krnm	1281	30	,	,	,
cord-022353-q2k2krnm	1281	31	orexin	orexin	NN
cord-022353-q2k2krnm	1281	32	B	b	NN
cord-022353-q2k2krnm	1281	33	,	,	,
cord-022353-q2k2krnm	1281	34	adiponectin	adiponectin	NN
cord-022353-q2k2krnm	1281	35	,	,	,
cord-022353-q2k2krnm	1281	36	adipsin	adipsin	NNP
cord-022353-q2k2krnm	1281	37	,	,	,
cord-022353-q2k2krnm	1281	38	and	and	CC
cord-022353-q2k2krnm	1281	39	resistin	resistin	NN
cord-022353-q2k2krnm	1281	40	.	.	.
cord-022353-q2k2krnm	1282	1	Each	each	DT
cord-022353-q2k2krnm	1282	2	of	of	IN
cord-022353-q2k2krnm	1282	3	these	these	DT
cord-022353-q2k2krnm	1282	4	hormones	hormone	NNS
cord-022353-q2k2krnm	1282	5	have	have	VBP
cord-022353-q2k2krnm	1282	6	been	be	VBN
cord-022353-q2k2krnm	1282	7	briefly	briefly	RB
cord-022353-q2k2krnm	1282	8	discussed	discuss	VBN
cord-022353-q2k2krnm	1282	9	in	in	IN
cord-022353-q2k2krnm	1282	10	the	the	DT
cord-022353-q2k2krnm	1282	11	"	"	``
cord-022353-q2k2krnm	1282	12	Glucose	Glucose	NNP
cord-022353-q2k2krnm	1282	13	and	and	CC
cord-022353-q2k2krnm	1282	14	Carbohydrate	Carbohydrate	NNP
cord-022353-q2k2krnm	1282	15	Metabolism	Metabolism	NNP
cord-022353-q2k2krnm	1282	16	"	"	''
cord-022353-q2k2krnm	1282	17	section	section	NN
cord-022353-q2k2krnm	1282	18	.	.	.
cord-022353-q2k2krnm	1283	1	The	the	DT
cord-022353-q2k2krnm	1283	2	liver	liver	NN
cord-022353-q2k2krnm	1283	3	has	have	VBZ
cord-022353-q2k2krnm	1283	4	many	many	JJ
cord-022353-q2k2krnm	1283	5	complex	complex	JJ
cord-022353-q2k2krnm	1283	6	functions	function	NNS
cord-022353-q2k2krnm	1283	7	including	include	VBG
cord-022353-q2k2krnm	1283	8	protein	protein	NN
cord-022353-q2k2krnm	1283	9	metabolism	metabolism	NN
cord-022353-q2k2krnm	1283	10	,	,	,
cord-022353-q2k2krnm	1283	11	carbohydrate	carbohydrate	NN
cord-022353-q2k2krnm	1283	12	metabolism	metabolism	NN
cord-022353-q2k2krnm	1283	13	,	,	,
cord-022353-q2k2krnm	1283	14	and	and	CC
cord-022353-q2k2krnm	1283	15	lipid	lipid	NN
cord-022353-q2k2krnm	1283	16	metabolism	metabolism	NN
cord-022353-q2k2krnm	1283	17	.	.	.
cord-022353-q2k2krnm	1284	1	The	the	DT
cord-022353-q2k2krnm	1284	2	liver	liver	NN
cord-022353-q2k2krnm	1284	3	is	be	VBZ
cord-022353-q2k2krnm	1284	4	involved	involve	VBN
cord-022353-q2k2krnm	1284	5	with	with	IN
cord-022353-q2k2krnm	1284	6	the	the	DT
cord-022353-q2k2krnm	1284	7	synthesis	synthesis	NN
cord-022353-q2k2krnm	1284	8	of	of	IN
cord-022353-q2k2krnm	1284	9	many	many	JJ
cord-022353-q2k2krnm	1284	10	plasma	plasma	NN
cord-022353-q2k2krnm	1284	11	proteins	protein	NNS
cord-022353-q2k2krnm	1284	12	(	(	-LRB-
cord-022353-q2k2krnm	1284	13	including	include	VBG
cord-022353-q2k2krnm	1284	14	albumin	albumin	NN
cord-022353-q2k2krnm	1284	15	)	)	-RRB-
cord-022353-q2k2krnm	1284	16	,	,	,
cord-022353-q2k2krnm	1284	17	the	the	DT
cord-022353-q2k2krnm	1284	18	conversion	conversion	NN
cord-022353-q2k2krnm	1284	19	of	of	IN
cord-022353-q2k2krnm	1284	20	ammonia	ammonia	NN
cord-022353-q2k2krnm	1284	21	to	to	IN
cord-022353-q2k2krnm	1284	22	urea	urea	NN
cord-022353-q2k2krnm	1284	23	,	,	,
cord-022353-q2k2krnm	1284	24	and	and	CC
cord-022353-q2k2krnm	1284	25	the	the	DT
cord-022353-q2k2krnm	1284	26	production	production	NN
cord-022353-q2k2krnm	1284	27	of	of	IN
cord-022353-q2k2krnm	1284	28	glucose	glucose	NN
cord-022353-q2k2krnm	1284	29	from	from	IN
cord-022353-q2k2krnm	1284	30	glucogenic	glucogenic	JJ
cord-022353-q2k2krnm	1284	31	amino	amino	JJ
cord-022353-q2k2krnm	1284	32	acids	acid	NNS
cord-022353-q2k2krnm	1284	33	)	)	-RRB-
cord-022353-q2k2krnm	1284	34	.	.	.
cord-022353-q2k2krnm	1285	1	The	the	DT
cord-022353-q2k2krnm	1285	2	liver	liver	NN
cord-022353-q2k2krnm	1285	3	is	be	VBZ
cord-022353-q2k2krnm	1285	4	implicated	implicate	VBN
cord-022353-q2k2krnm	1285	5	with	with	IN
cord-022353-q2k2krnm	1285	6	the	the	DT
cord-022353-q2k2krnm	1285	7	regulation	regulation	NN
cord-022353-q2k2krnm	1285	8	of	of	IN
cord-022353-q2k2krnm	1285	9	blood	blood	NN
cord-022353-q2k2krnm	1285	10	glucose	glucose	NN
cord-022353-q2k2krnm	1285	11	levels	level	NNS
cord-022353-q2k2krnm	1285	12	(	(	-LRB-
cord-022353-q2k2krnm	1285	13	via	via	IN
cord-022353-q2k2krnm	1285	14	glycogenolysis	glycogenolysis	NN
cord-022353-q2k2krnm	1285	15	and	and	CC
cord-022353-q2k2krnm	1285	16	gluconeogenesis	gluconeogenesis	NN
cord-022353-q2k2krnm	1285	17	,	,	,
cord-022353-q2k2krnm	1285	18	as	as	IN
cord-022353-q2k2krnm	1285	19	discussed	discuss	VBN
cord-022353-q2k2krnm	1285	20	in	in	IN
cord-022353-q2k2krnm	1285	21	the	the	DT
cord-022353-q2k2krnm	1285	22	"	"	``
cord-022353-q2k2krnm	1285	23	Glucose	Glucose	NNP
cord-022353-q2k2krnm	1285	24	and	and	CC
cord-022353-q2k2krnm	1285	25	Carbohydrate	Carbohydrate	NNP
cord-022353-q2k2krnm	1285	26	Metabolism	Metabolism	NNP
cord-022353-q2k2krnm	1285	27	"	"	''
cord-022353-q2k2krnm	1285	28	section	section	NN
cord-022353-q2k2krnm	1285	29	)	)	-RRB-
cord-022353-q2k2krnm	1285	30	,	,	,
cord-022353-q2k2krnm	1285	31	the	the	DT
cord-022353-q2k2krnm	1285	32	removal	removal	NN
cord-022353-q2k2krnm	1285	33	of	of	IN
cord-022353-q2k2krnm	1285	34	glucose	glucose	NN
cord-022353-q2k2krnm	1285	35	from	from	IN
cord-022353-q2k2krnm	1285	36	the	the	DT
cord-022353-q2k2krnm	1285	37	blood	blood	NN
cord-022353-q2k2krnm	1285	38	via	via	IN
cord-022353-q2k2krnm	1285	39	GLUT-1	GLUT-1	NNS
cord-022353-q2k2krnm	1285	40	and	and	CC
cord-022353-q2k2krnm	1285	41	GLUT-2	glut-2	NN
cord-022353-q2k2krnm	1285	42	membrane	membrane	NN
cord-022353-q2k2krnm	1285	43	transporters	transporter	NNS
cord-022353-q2k2krnm	1285	44	,	,	,
cord-022353-q2k2krnm	1285	45	and	and	CC
cord-022353-q2k2krnm	1285	46	storage	storage	NN
cord-022353-q2k2krnm	1285	47	in	in	IN
cord-022353-q2k2krnm	1285	48	the	the	DT
cord-022353-q2k2krnm	1285	49	form	form	NN
cord-022353-q2k2krnm	1285	50	of	of	IN
cord-022353-q2k2krnm	1285	51	glycogen	glycogen	NN
cord-022353-q2k2krnm	1285	52	.	.	.
cord-022353-q2k2krnm	1286	1	The	the	DT
cord-022353-q2k2krnm	1286	2	liver	liver	NN
cord-022353-q2k2krnm	1286	3	is	be	VBZ
cord-022353-q2k2krnm	1286	4	also	also	RB
cord-022353-q2k2krnm	1286	5	involved	involve	VBN
cord-022353-q2k2krnm	1286	6	in	in	IN
cord-022353-q2k2krnm	1286	7	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1286	8	and	and	CC
cord-022353-q2k2krnm	1286	9	triglyceride	triglyceride	NN
cord-022353-q2k2krnm	1286	10	synthesis	synthesis	NN
cord-022353-q2k2krnm	1286	11	,	,	,
cord-022353-q2k2krnm	1286	12	the	the	DT
cord-022353-q2k2krnm	1286	13	formation	formation	NN
cord-022353-q2k2krnm	1286	14	of	of	IN
cord-022353-q2k2krnm	1286	15	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	1286	16	(	(	-LRB-
cord-022353-q2k2krnm	1286	17	discussed	discuss	VBN
cord-022353-q2k2krnm	1286	18	in	in	IN
cord-022353-q2k2krnm	1286	19	the	the	DT
cord-022353-q2k2krnm	1286	20	"	"	``
cord-022353-q2k2krnm	1286	21	Lipid	Lipid	NNP
cord-022353-q2k2krnm	1286	22	Metabolism	Metabolism	NNP
cord-022353-q2k2krnm	1286	23	"	"	''
cord-022353-q2k2krnm	1286	24	section	section	NN
cord-022353-q2k2krnm	1286	25	)	)	-RRB-
cord-022353-q2k2krnm	1286	26	,	,	,
cord-022353-q2k2krnm	1286	27	and	and	CC
cord-022353-q2k2krnm	1286	28	the	the	DT
cord-022353-q2k2krnm	1286	29	synthesis	synthesis	NN
cord-022353-q2k2krnm	1286	30	of	of	IN
cord-022353-q2k2krnm	1286	31	carbohydrates	carbohydrate	NNS
cord-022353-q2k2krnm	1286	32	from	from	IN
cord-022353-q2k2krnm	1286	33	fats	fat	NNS
cord-022353-q2k2krnm	1286	34	.	.	.
cord-022353-q2k2krnm	1287	1	There	there	EX
cord-022353-q2k2krnm	1287	2	are	be	VBP
cord-022353-q2k2krnm	1287	3	also	also	RB
cord-022353-q2k2krnm	1287	4	other	other	JJ
cord-022353-q2k2krnm	1287	5	more	more	RBR
cord-022353-q2k2krnm	1287	6	specific	specific	JJ
cord-022353-q2k2krnm	1287	7	functions	function	NNS
cord-022353-q2k2krnm	1287	8	that	that	WDT
cord-022353-q2k2krnm	1287	9	the	the	DT
cord-022353-q2k2krnm	1287	10	liver	liver	NN
cord-022353-q2k2krnm	1287	11	facilitates	facilitate	VBZ
cord-022353-q2k2krnm	1287	12	,	,	,
cord-022353-q2k2krnm	1287	13	including	include	VBG
cord-022353-q2k2krnm	1287	14	the	the	DT
cord-022353-q2k2krnm	1287	15	synthesis	synthesis	NN
cord-022353-q2k2krnm	1287	16	of	of	IN
cord-022353-q2k2krnm	1287	17	heme	heme	NN
cord-022353-q2k2krnm	1287	18	,	,	,
cord-022353-q2k2krnm	1287	19	the	the	DT
cord-022353-q2k2krnm	1287	20	synthesis	synthesis	NN
cord-022353-q2k2krnm	1287	21	of	of	IN
cord-022353-q2k2krnm	1287	22	many	many	JJ
cord-022353-q2k2krnm	1287	23	coenzymes	coenzyme	NNS
cord-022353-q2k2krnm	1287	24	,	,	,
cord-022353-q2k2krnm	1287	25	detoxification	detoxification	NN
cord-022353-q2k2krnm	1287	26	/	/	SYM
cord-022353-q2k2krnm	1287	27	biotransformation	biotransformation	NN
cord-022353-q2k2krnm	1287	28	of	of	IN
cord-022353-q2k2krnm	1287	29	exogenous	exogenous	JJ
cord-022353-q2k2krnm	1287	30	and	and	CC
cord-022353-q2k2krnm	1287	31	endogenous	endogenous	JJ
cord-022353-q2k2krnm	1287	32	substances	substance	NNS
cord-022353-q2k2krnm	1287	33	via	via	IN
cord-022353-q2k2krnm	1287	34	the	the	DT
cord-022353-q2k2krnm	1287	35	cytochrome	cytochrome	NN
cord-022353-q2k2krnm	1287	36	P-450	P-450	VBD
cord-022353-q2k2krnm	1287	37	microsomal	microsomal	FW
cord-022353-q2k2krnm	1287	38	enzymes	enzyme	NNS
cord-022353-q2k2krnm	1287	39	,	,	,
cord-022353-q2k2krnm	1287	40	and	and	CC
cord-022353-q2k2krnm	1287	41	the	the	DT
cord-022353-q2k2krnm	1287	42	synthesis	synthesis	NN
cord-022353-q2k2krnm	1287	43	of	of	IN
cord-022353-q2k2krnm	1287	44	bile	bile	NN
cord-022353-q2k2krnm	1287	45	.	.	.
cord-022353-q2k2krnm	1288	1	The	the	DT
cord-022353-q2k2krnm	1288	2	role	role	NN
cord-022353-q2k2krnm	1288	3	of	of	IN
cord-022353-q2k2krnm	1288	4	the	the	DT
cord-022353-q2k2krnm	1288	5	liver	liver	NN
cord-022353-q2k2krnm	1288	6	in	in	IN
cord-022353-q2k2krnm	1288	7	these	these	DT
cord-022353-q2k2krnm	1288	8	functions	function	NNS
cord-022353-q2k2krnm	1288	9	for	for	IN
cord-022353-q2k2krnm	1288	10	various	various	JJ
cord-022353-q2k2krnm	1288	11	animals	animal	NNS
cord-022353-q2k2krnm	1288	12	has	have	VBZ
cord-022353-q2k2krnm	1288	13	been	be	VBN
cord-022353-q2k2krnm	1288	14	reviewed	review	VBN
cord-022353-q2k2krnm	1288	15	(	(	-LRB-
cord-022353-q2k2krnm	1288	16	Tennant	Tennant	NNP
cord-022353-q2k2krnm	1288	17	1999	1999	CD
cord-022353-q2k2krnm	1288	18	;	;	:
cord-022353-q2k2krnm	1288	19	Woodman	Woodman	NNP
cord-022353-q2k2krnm	1288	20	1988	1988	CD
cord-022353-q2k2krnm	1288	21	)	)	-RRB-
cord-022353-q2k2krnm	1288	22	.	.	.
cord-022353-q2k2krnm	1289	1	The	the	DT
cord-022353-q2k2krnm	1289	2	elevation	elevation	NN
cord-022353-q2k2krnm	1289	3	of	of	IN
cord-022353-q2k2krnm	1289	4	plasma	plasma	NN
cord-022353-q2k2krnm	1289	5	or	or	CC
cord-022353-q2k2krnm	1289	6	serum	serum	NN
cord-022353-q2k2krnm	1289	7	enzymes	enzyme	NNS
cord-022353-q2k2krnm	1289	8	usually	usually	RB
cord-022353-q2k2krnm	1289	9	confined	confine	VBN
cord-022353-q2k2krnm	1289	10	to	to	IN
cord-022353-q2k2krnm	1289	11	the	the	DT
cord-022353-q2k2krnm	1289	12	cytosol	cytosol	NN
cord-022353-q2k2krnm	1289	13	or	or	CC
cord-022353-q2k2krnm	1289	14	mitochondria	mitochondrion	NNS
cord-022353-q2k2krnm	1289	15	of	of	IN
cord-022353-q2k2krnm	1289	16	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	1289	17	is	be	VBZ
cord-022353-q2k2krnm	1289	18	helpful	helpful	JJ
cord-022353-q2k2krnm	1289	19	in	in	IN
cord-022353-q2k2krnm	1289	20	elucidating	elucidate	VBG
cord-022353-q2k2krnm	1289	21	liver	liver	NN
cord-022353-q2k2krnm	1289	22	injury	injury	NN
cord-022353-q2k2krnm	1289	23	.	.	.
cord-022353-q2k2krnm	1290	1	Many	many	JJ
cord-022353-q2k2krnm	1290	2	factors	factor	NNS
cord-022353-q2k2krnm	1290	3	influence	influence	VBP
cord-022353-q2k2krnm	1290	4	the	the	DT
cord-022353-q2k2krnm	1290	5	duration	duration	NN
cord-022353-q2k2krnm	1290	6	of	of	IN
cord-022353-q2k2krnm	1290	7	elevated	elevated	JJ
cord-022353-q2k2krnm	1290	8	serum	serum	NN
cord-022353-q2k2krnm	1290	9	enzyme	enzyme	NN
cord-022353-q2k2krnm	1290	10	levels	level	NNS
cord-022353-q2k2krnm	1290	11	including	include	VBG
cord-022353-q2k2krnm	1290	12	molecular	molecular	JJ
cord-022353-q2k2krnm	1290	13	size	size	NN
cord-022353-q2k2krnm	1290	14	,	,	,
cord-022353-q2k2krnm	1290	15	intracellular	intracellular	JJ
cord-022353-q2k2krnm	1290	16	location	location	NN
cord-022353-q2k2krnm	1290	17	,	,	,
cord-022353-q2k2krnm	1290	18	rate	rate	NN
cord-022353-q2k2krnm	1290	19	of	of	IN
cord-022353-q2k2krnm	1290	20	plasma	plasma	NN
cord-022353-q2k2krnm	1290	21	clearance	clearance	NN
cord-022353-q2k2krnm	1290	22	,	,	,
cord-022353-q2k2krnm	1290	23	rate	rate	NN
cord-022353-q2k2krnm	1290	24	of	of	IN
cord-022353-q2k2krnm	1290	25	enzyme	enzyme	NN
cord-022353-q2k2krnm	1290	26	inactivation	inactivation	NN
cord-022353-q2k2krnm	1290	27	,	,	,
cord-022353-q2k2krnm	1290	28	and	and	CC
cord-022353-q2k2krnm	1290	29	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1290	30	production	production	NN
cord-022353-q2k2krnm	1290	31	.	.	.
cord-022353-q2k2krnm	1291	1	Hepatic	hepatic	JJ
cord-022353-q2k2krnm	1291	2	necrosis	necrosis	NN
cord-022353-q2k2krnm	1291	3	is	be	VBZ
cord-022353-q2k2krnm	1291	4	associated	associate	VBN
cord-022353-q2k2krnm	1291	5	with	with	IN
cord-022353-q2k2krnm	1291	6	elevations	elevation	NNS
cord-022353-q2k2krnm	1291	7	of	of	IN
cord-022353-q2k2krnm	1291	8	ALT	ALT	NNP
cord-022353-q2k2krnm	1291	9	,	,	,
cord-022353-q2k2krnm	1291	10	AST	AST	NNP
cord-022353-q2k2krnm	1291	11	,	,	,
cord-022353-q2k2krnm	1291	12	SD	SD	NNP
cord-022353-q2k2krnm	1291	13	,	,	,
cord-022353-q2k2krnm	1291	14	and	and	CC
cord-022353-q2k2krnm	1291	15	OTC	OTC	NNP
cord-022353-q2k2krnm	1291	16	in	in	IN
cord-022353-q2k2krnm	1291	17	mice	mouse	NNS
cord-022353-q2k2krnm	1291	18	,	,	,
cord-022353-q2k2krnm	1291	19	and	and	CC
cord-022353-q2k2krnm	1291	20	extrahepatic	extrahepatic	JJ
cord-022353-q2k2krnm	1291	21	cholestasis	cholestasis	NN
cord-022353-q2k2krnm	1291	22	is	be	VBZ
cord-022353-q2k2krnm	1291	23	associated	associate	VBN
cord-022353-q2k2krnm	1291	24	with	with	IN
cord-022353-q2k2krnm	1291	25	elevated	elevated	JJ
cord-022353-q2k2krnm	1291	26	AP	AP	NNP
cord-022353-q2k2krnm	1291	27	(	(	-LRB-
cord-022353-q2k2krnm	1291	28	Tennant	Tennant	NNP
cord-022353-q2k2krnm	1291	29	1999	1999	CD
cord-022353-q2k2krnm	1291	30	)	)	-RRB-
cord-022353-q2k2krnm	1291	31	.	.	.
cord-022353-q2k2krnm	1292	1	Please	please	UH
cord-022353-q2k2krnm	1292	2	refer	refer	VB
cord-022353-q2k2krnm	1292	3	to	to	IN
cord-022353-q2k2krnm	1292	4	the	the	DT
cord-022353-q2k2krnm	1292	5	"	"	``
cord-022353-q2k2krnm	1292	6	Enzymes	enzyme	NNS
cord-022353-q2k2krnm	1292	7	"	"	''
cord-022353-q2k2krnm	1292	8	section	section	NN
cord-022353-q2k2krnm	1292	9	for	for	IN
cord-022353-q2k2krnm	1292	10	a	a	DT
cord-022353-q2k2krnm	1292	11	description	description	NN
cord-022353-q2k2krnm	1292	12	of	of	IN
cord-022353-q2k2krnm	1292	13	each	each	DT
cord-022353-q2k2krnm	1292	14	enzyme	enzyme	NN
cord-022353-q2k2krnm	1292	15	.	.	.
cord-022353-q2k2krnm	1293	1	Bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1293	2	is	be	VBZ
cord-022353-q2k2krnm	1293	3	a	a	DT
cord-022353-q2k2krnm	1293	4	pigment	pigment	NN
cord-022353-q2k2krnm	1293	5	that	that	WDT
cord-022353-q2k2krnm	1293	6	is	be	VBZ
cord-022353-q2k2krnm	1293	7	produced	produce	VBN
cord-022353-q2k2krnm	1293	8	by	by	IN
cord-022353-q2k2krnm	1293	9	the	the	DT
cord-022353-q2k2krnm	1293	10	degradation	degradation	NN
cord-022353-q2k2krnm	1293	11	of	of	IN
cord-022353-q2k2krnm	1293	12	the	the	DT
cord-022353-q2k2krnm	1293	13	hemoglobin	hemoglobin	NN
cord-022353-q2k2krnm	1293	14	by	by	IN
cord-022353-q2k2krnm	1293	15	cells	cell	NNS
cord-022353-q2k2krnm	1293	16	of	of	IN
cord-022353-q2k2krnm	1293	17	the	the	DT
cord-022353-q2k2krnm	1293	18	mononuclear	mononuclear	JJ
cord-022353-q2k2krnm	1293	19	phagocyte	phagocyte	NNP
cord-022353-q2k2krnm	1293	20	system	system	NN
cord-022353-q2k2krnm	1293	21	.	.	.
cord-022353-q2k2krnm	1294	1	There	there	EX
cord-022353-q2k2krnm	1294	2	are	be	VBP
cord-022353-q2k2krnm	1294	3	two	two	CD
cord-022353-q2k2krnm	1294	4	main	main	JJ
cord-022353-q2k2krnm	1294	5	types	type	NNS
cord-022353-q2k2krnm	1294	6	of	of	IN
cord-022353-q2k2krnm	1294	7	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1294	8	.	.	.
cord-022353-q2k2krnm	1295	1	Unconjugated	unconjugated	JJ
cord-022353-q2k2krnm	1295	2	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1295	3	is	be	VBZ
cord-022353-q2k2krnm	1295	4	a	a	DT
cord-022353-q2k2krnm	1295	5	non	non	JJ
cord-022353-q2k2krnm	1295	6	-	-	JJ
cord-022353-q2k2krnm	1295	7	water	water	JJ
cord-022353-q2k2krnm	1295	8	soluble	soluble	JJ
cord-022353-q2k2krnm	1295	9	molecule	molecule	NN
cord-022353-q2k2krnm	1295	10	that	that	WDT
cord-022353-q2k2krnm	1295	11	is	be	VBZ
cord-022353-q2k2krnm	1295	12	transported	transport	VBN
cord-022353-q2k2krnm	1295	13	in	in	IN
cord-022353-q2k2krnm	1295	14	blood	blood	NN
cord-022353-q2k2krnm	1295	15	bound	bind	VBN
cord-022353-q2k2krnm	1295	16	to	to	IN
cord-022353-q2k2krnm	1295	17	albumin	albumin	NN
cord-022353-q2k2krnm	1295	18	.	.	.
cord-022353-q2k2krnm	1296	1	Hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	1296	2	uptake	uptake	NN
cord-022353-q2k2krnm	1296	3	unconjugated	unconjugated	JJ
cord-022353-q2k2krnm	1296	4	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1296	5	,	,	,
cord-022353-q2k2krnm	1296	6	where	where	WRB
cord-022353-q2k2krnm	1296	7	it	-PRON-	PRP
cord-022353-q2k2krnm	1296	8	undergoes	undergo	VBZ
cord-022353-q2k2krnm	1296	9	glucuronidation	glucuronidation	NN
cord-022353-q2k2krnm	1296	10	to	to	TO
cord-022353-q2k2krnm	1296	11	produce	produce	VB
cord-022353-q2k2krnm	1296	12	the	the	DT
cord-022353-q2k2krnm	1296	13	water	water	NN
cord-022353-q2k2krnm	1296	14	-	-	HYPH
cord-022353-q2k2krnm	1296	15	soluble	soluble	JJ
cord-022353-q2k2krnm	1296	16	form	form	NN
cord-022353-q2k2krnm	1296	17	,	,	,
cord-022353-q2k2krnm	1296	18	conjugated	conjugate	VBN
cord-022353-q2k2krnm	1296	19	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1296	20	.	.	.
cord-022353-q2k2krnm	1297	1	Conjugated	conjugated	JJ
cord-022353-q2k2krnm	1297	2	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1297	3	is	be	VBZ
cord-022353-q2k2krnm	1297	4	then	then	RB
cord-022353-q2k2krnm	1297	5	excreted	excrete	VBN
cord-022353-q2k2krnm	1297	6	via	via	IN
cord-022353-q2k2krnm	1297	7	the	the	DT
cord-022353-q2k2krnm	1297	8	hepatobiliary	hepatobiliary	JJ
cord-022353-q2k2krnm	1297	9	system	system	NN
cord-022353-q2k2krnm	1297	10	and	and	CC
cord-022353-q2k2krnm	1297	11	excreted	excrete	VBN
cord-022353-q2k2krnm	1297	12	in	in	IN
cord-022353-q2k2krnm	1297	13	bile	bile	NN
cord-022353-q2k2krnm	1297	14	.	.	.
cord-022353-q2k2krnm	1298	1	Quantification	quantification	NN
cord-022353-q2k2krnm	1298	2	of	of	IN
cord-022353-q2k2krnm	1298	3	serum	serum	NN
cord-022353-q2k2krnm	1298	4	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1298	5	levels	level	NNS
cord-022353-q2k2krnm	1298	6	is	be	VBZ
cord-022353-q2k2krnm	1298	7	based	base	VBN
cord-022353-q2k2krnm	1298	8	on	on	IN
cord-022353-q2k2krnm	1298	9	the	the	DT
cord-022353-q2k2krnm	1298	10	van	van	NNP
cord-022353-q2k2krnm	1298	11	den	den	NNP
cord-022353-q2k2krnm	1298	12	Bergh	Bergh	NNP
cord-022353-q2k2krnm	1298	13	or	or	CC
cord-022353-q2k2krnm	1298	14	diazo	diazo	JJ
cord-022353-q2k2krnm	1298	15	reaction	reaction	NN
cord-022353-q2k2krnm	1298	16	.	.	.
cord-022353-q2k2krnm	1299	1	Diazo	Diazo	NNP
cord-022353-q2k2krnm	1299	2	reacts	react	VBZ
cord-022353-q2k2krnm	1299	3	directly	directly	RB
cord-022353-q2k2krnm	1299	4	with	with	IN
cord-022353-q2k2krnm	1299	5	conjugated	conjugated	JJ
cord-022353-q2k2krnm	1299	6	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1299	7	,	,	,
cord-022353-q2k2krnm	1299	8	and	and	CC
cord-022353-q2k2krnm	1299	9	with	with	IN
cord-022353-q2k2krnm	1299	10	unconjugated	unconjugated	JJ
cord-022353-q2k2krnm	1299	11	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1299	12	only	only	RB
cord-022353-q2k2krnm	1299	13	after	after	IN
cord-022353-q2k2krnm	1299	14	addition	addition	NN
cord-022353-q2k2krnm	1299	15	of	of	IN
cord-022353-q2k2krnm	1299	16	alcohol	alcohol	NN
cord-022353-q2k2krnm	1299	17	to	to	IN
cord-022353-q2k2krnm	1299	18	the	the	DT
cord-022353-q2k2krnm	1299	19	reaction	reaction	NN
cord-022353-q2k2krnm	1299	20	.	.	.
cord-022353-q2k2krnm	1300	1	Therefore	therefore	RB
cord-022353-q2k2krnm	1300	2	,	,	,
cord-022353-q2k2krnm	1300	3	measuring	measure	VBG
cord-022353-q2k2krnm	1300	4	serum	serum	NN
cord-022353-q2k2krnm	1300	5	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1300	6	involves	involve	VBZ
cord-022353-q2k2krnm	1300	7	the	the	DT
cord-022353-q2k2krnm	1300	8	following	follow	VBG
cord-022353-q2k2krnm	1300	9	steps	step	NNS
cord-022353-q2k2krnm	1300	10	.	.	.
cord-022353-q2k2krnm	1301	1	First	first	RB
cord-022353-q2k2krnm	1301	2	,	,	,
cord-022353-q2k2krnm	1301	3	the	the	DT
cord-022353-q2k2krnm	1301	4	level	level	NN
cord-022353-q2k2krnm	1301	5	of	of	IN
cord-022353-q2k2krnm	1301	6	conjugated	conjugated	JJ
cord-022353-q2k2krnm	1301	7	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1301	8	is	be	VBZ
cord-022353-q2k2krnm	1301	9	measured	measure	VBN
cord-022353-q2k2krnm	1301	10	.	.	.
cord-022353-q2k2krnm	1302	1	Second	second	JJ
cord-022353-q2k2krnm	1302	2	,	,	,
cord-022353-q2k2krnm	1302	3	alcohol	alcohol	NN
cord-022353-q2k2krnm	1302	4	is	be	VBZ
cord-022353-q2k2krnm	1302	5	added	add	VBN
cord-022353-q2k2krnm	1302	6	to	to	IN
cord-022353-q2k2krnm	1302	7	the	the	DT
cord-022353-q2k2krnm	1302	8	reactants	reactant	NNS
cord-022353-q2k2krnm	1302	9	,	,	,
cord-022353-q2k2krnm	1302	10	which	which	WDT
cord-022353-q2k2krnm	1302	11	allows	allow	VBZ
cord-022353-q2k2krnm	1302	12	quantification	quantification	NN
cord-022353-q2k2krnm	1302	13	of	of	IN
cord-022353-q2k2krnm	1302	14	total	total	JJ
cord-022353-q2k2krnm	1302	15	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1302	16	levels	level	NNS
cord-022353-q2k2krnm	1302	17	.	.	.
cord-022353-q2k2krnm	1303	1	Finally	finally	RB
cord-022353-q2k2krnm	1303	2	,	,	,
cord-022353-q2k2krnm	1303	3	the	the	DT
cord-022353-q2k2krnm	1303	4	level	level	NN
cord-022353-q2k2krnm	1303	5	of	of	IN
cord-022353-q2k2krnm	1303	6	unconjugated	unconjugated	JJ
cord-022353-q2k2krnm	1303	7	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1303	8	is	be	VBZ
cord-022353-q2k2krnm	1303	9	determined	determine	VBN
cord-022353-q2k2krnm	1303	10	by	by	IN
cord-022353-q2k2krnm	1303	11	subtracting	subtract	VBG
cord-022353-q2k2krnm	1303	12	the	the	DT
cord-022353-q2k2krnm	1303	13	conjugated	conjugated	JJ
cord-022353-q2k2krnm	1303	14	measurement	measurement	NN
cord-022353-q2k2krnm	1303	15	from	from	IN
cord-022353-q2k2krnm	1303	16	the	the	DT
cord-022353-q2k2krnm	1303	17	total	total	JJ
cord-022353-q2k2krnm	1303	18	measurement	measurement	NN
cord-022353-q2k2krnm	1303	19	.	.	.
cord-022353-q2k2krnm	1304	1	The	the	DT
cord-022353-q2k2krnm	1304	2	excretory	excretory	JJ
cord-022353-q2k2krnm	1304	3	capacity	capacity	NN
cord-022353-q2k2krnm	1304	4	of	of	IN
cord-022353-q2k2krnm	1304	5	the	the	DT
cord-022353-q2k2krnm	1304	6	liver	liver	NN
cord-022353-q2k2krnm	1304	7	may	may	MD
cord-022353-q2k2krnm	1304	8	be	be	VB
cord-022353-q2k2krnm	1304	9	assessed	assess	VBN
cord-022353-q2k2krnm	1304	10	by	by	IN
cord-022353-q2k2krnm	1304	11	measuring	measure	VBG
cord-022353-q2k2krnm	1304	12	serum	serum	NN
cord-022353-q2k2krnm	1304	13	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1304	14	.	.	.
cord-022353-q2k2krnm	1305	1	Elevated	elevated	JJ
cord-022353-q2k2krnm	1305	2	levels	level	NNS
cord-022353-q2k2krnm	1305	3	of	of	IN
cord-022353-q2k2krnm	1305	4	unconjugated	unconjugated	JJ
cord-022353-q2k2krnm	1305	5	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1305	6	are	be	VBP
cord-022353-q2k2krnm	1305	7	usually	usually	RB
cord-022353-q2k2krnm	1305	8	observed	observe	VBN
cord-022353-q2k2krnm	1305	9	in	in	IN
cord-022353-q2k2krnm	1305	10	situations	situation	NNS
cord-022353-q2k2krnm	1305	11	of	of	IN
cord-022353-q2k2krnm	1305	12	increased	increase	VBN
cord-022353-q2k2krnm	1305	13	erythrocyte	erythrocyte	NN
cord-022353-q2k2krnm	1305	14	breakdown	breakdown	NN
cord-022353-q2k2krnm	1305	15	,	,	,
cord-022353-q2k2krnm	1305	16	such	such	JJ
cord-022353-q2k2krnm	1305	17	as	as	IN
cord-022353-q2k2krnm	1305	18	in	in	IN
cord-022353-q2k2krnm	1305	19	hemolytic	hemolytic	JJ
cord-022353-q2k2krnm	1305	20	diseases	disease	NNS
cord-022353-q2k2krnm	1305	21	.	.	.
cord-022353-q2k2krnm	1306	1	Unconjugated	unconjugate	VBN
cord-022353-q2k2krnm	1306	2	hyperbilirubinemia	hyperbilirubinemia	NN
cord-022353-q2k2krnm	1306	3	is	be	VBZ
cord-022353-q2k2krnm	1306	4	also	also	RB
cord-022353-q2k2krnm	1306	5	seen	see	VBN
cord-022353-q2k2krnm	1306	6	in	in	IN
cord-022353-q2k2krnm	1306	7	disease	disease	NN
cord-022353-q2k2krnm	1306	8	in	in	IN
cord-022353-q2k2krnm	1306	9	which	which	WDT
cord-022353-q2k2krnm	1306	10	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1306	11	uptake	uptake	NN
cord-022353-q2k2krnm	1306	12	,	,	,
cord-022353-q2k2krnm	1306	13	conjugation	conjugation	NN
cord-022353-q2k2krnm	1306	14	,	,	,
cord-022353-q2k2krnm	1306	15	and	and	CC
cord-022353-q2k2krnm	1306	16	secretion	secretion	NN
cord-022353-q2k2krnm	1306	17	of	of	IN
cord-022353-q2k2krnm	1306	18	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1306	19	are	be	VBP
cord-022353-q2k2krnm	1306	20	diminished	diminish	VBN
cord-022353-q2k2krnm	1306	21	.	.	.
cord-022353-q2k2krnm	1307	1	Increased	increase	VBN
cord-022353-q2k2krnm	1307	2	levels	level	NNS
cord-022353-q2k2krnm	1307	3	of	of	IN
cord-022353-q2k2krnm	1307	4	conjugated	conjugated	JJ
cord-022353-q2k2krnm	1307	5	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1307	6	are	be	VBP
cord-022353-q2k2krnm	1307	7	usually	usually	RB
cord-022353-q2k2krnm	1307	8	associated	associate	VBN
cord-022353-q2k2krnm	1307	9	with	with	IN
cord-022353-q2k2krnm	1307	10	intrahepatic	intrahepatic	JJ
cord-022353-q2k2krnm	1307	11	cholestasis	cholestasis	NN
cord-022353-q2k2krnm	1307	12	or	or	CC
cord-022353-q2k2krnm	1307	13	extrahepatic	extrahepatic	JJ
cord-022353-q2k2krnm	1307	14	bile	bile	NN
cord-022353-q2k2krnm	1307	15	duct	duct	NN
cord-022353-q2k2krnm	1307	16	obstruction	obstruction	NN
cord-022353-q2k2krnm	1307	17	.	.	.
cord-022353-q2k2krnm	1308	1	Conjugated	conjugate	VBN
cord-022353-q2k2krnm	1308	2	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1308	3	in	in	IN
cord-022353-q2k2krnm	1308	4	blood	blood	NN
cord-022353-q2k2krnm	1308	5	is	be	VBZ
cord-022353-q2k2krnm	1308	6	normally	normally	RB
cord-022353-q2k2krnm	1308	7	filtered	filter	VBN
cord-022353-q2k2krnm	1308	8	by	by	IN
cord-022353-q2k2krnm	1308	9	the	the	DT
cord-022353-q2k2krnm	1308	10	glomerulus	glomerulus	NN
cord-022353-q2k2krnm	1308	11	in	in	IN
cord-022353-q2k2krnm	1308	12	small	small	JJ
cord-022353-q2k2krnm	1308	13	amounts	amount	NNS
cord-022353-q2k2krnm	1308	14	.	.	.
cord-022353-q2k2krnm	1309	1	Conjugated	conjugate	VBN
cord-022353-q2k2krnm	1309	2	hyperbilirubinemia	hyperbilirubinemia	NNP
cord-022353-q2k2krnm	1309	3	may	may	MD
cord-022353-q2k2krnm	1309	4	result	result	VB
cord-022353-q2k2krnm	1309	5	in	in	IN
cord-022353-q2k2krnm	1309	6	bilirubinuria	bilirubinuria	NNS
cord-022353-q2k2krnm	1309	7	(	(	-LRB-
cord-022353-q2k2krnm	1309	8	Tennant	Tennant	NNP
cord-022353-q2k2krnm	1309	9	1999	1999	CD
cord-022353-q2k2krnm	1309	10	)	)	-RRB-
cord-022353-q2k2krnm	1309	11	.	.	.
cord-022353-q2k2krnm	1310	1	Bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1310	2	clearance	clearance	NN
cord-022353-q2k2krnm	1310	3	from	from	IN
cord-022353-q2k2krnm	1310	4	blood	blood	NN
cord-022353-q2k2krnm	1310	5	and	and	CC
cord-022353-q2k2krnm	1310	6	the	the	DT
cord-022353-q2k2krnm	1310	7	role	role	NN
cord-022353-q2k2krnm	1310	8	of	of	IN
cord-022353-q2k2krnm	1310	9	the	the	DT
cord-022353-q2k2krnm	1310	10	constitutive	constitutive	JJ
cord-022353-q2k2krnm	1310	11	androstane	androstane	NNP
cord-022353-q2k2krnm	1310	12	receptor	receptor	NN
cord-022353-q2k2krnm	1310	13	in	in	IN
cord-022353-q2k2krnm	1310	14	this	this	DT
cord-022353-q2k2krnm	1310	15	process	process	NN
cord-022353-q2k2krnm	1310	16	has	have	VBZ
cord-022353-q2k2krnm	1310	17	been	be	VBN
cord-022353-q2k2krnm	1310	18	studied	study	VBN
cord-022353-q2k2krnm	1310	19	in	in	IN
cord-022353-q2k2krnm	1310	20	normal	normal	JJ
cord-022353-q2k2krnm	1310	21	and	and	CC
cord-022353-q2k2krnm	1310	22	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1310	23	mice	mouse	NNS
cord-022353-q2k2krnm	1310	24	(	(	-LRB-
cord-022353-q2k2krnm	1310	25	Huang	Huang	NNP
cord-022353-q2k2krnm	1310	26	et	et	NNP
cord-022353-q2k2krnm	1310	27	al	al	NNP
cord-022353-q2k2krnm	1310	28	.	.	NNP
cord-022353-q2k2krnm	1310	29	2003	2003	CD
cord-022353-q2k2krnm	1310	30	;	;	:
cord-022353-q2k2krnm	1310	31	.	.	.
cord-022353-q2k2krnm	1311	1	Studies	study	NNS
cord-022353-q2k2krnm	1311	2	documenting	document	VBG
cord-022353-q2k2krnm	1311	3	the	the	DT
cord-022353-q2k2krnm	1311	4	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1311	5	-	-	HYPH
cord-022353-q2k2krnm	1311	6	metabolism	metabolism	NN
cord-022353-q2k2krnm	1311	7	/	/	SYM
cord-022353-q2k2krnm	1311	8	detoxifying	detoxify	VBG
cord-022353-q2k2krnm	1311	9	enzymes	enzyme	NNS
cord-022353-q2k2krnm	1311	10	,	,	,
cord-022353-q2k2krnm	1311	11	their	-PRON-	PRP$
cord-022353-q2k2krnm	1311	12	regulatory	regulatory	JJ
cord-022353-q2k2krnm	1311	13	nuclear	nuclear	JJ
cord-022353-q2k2krnm	1311	14	receptors	receptor	NNS
cord-022353-q2k2krnm	1311	15	,	,	,
cord-022353-q2k2krnm	1311	16	and	and	CC
cord-022353-q2k2krnm	1311	17	lipid	lipid	NN
cord-022353-q2k2krnm	1311	18	transporters	transporter	NNS
cord-022353-q2k2krnm	1311	19	in	in	IN
cord-022353-q2k2krnm	1311	20	mice	mouse	NNS
cord-022353-q2k2krnm	1311	21	have	have	VBP
cord-022353-q2k2krnm	1311	22	been	be	VBN
cord-022353-q2k2krnm	1311	23	reported	report	VBN
cord-022353-q2k2krnm	1311	24	(	(	-LRB-
cord-022353-q2k2krnm	1311	25	Wagner	Wagner	NNP
cord-022353-q2k2krnm	1311	26	et	et	NNP
cord-022353-q2k2krnm	1311	27	al	al	NNP
cord-022353-q2k2krnm	1311	28	.	.	NNP
cord-022353-q2k2krnm	1311	29	2005	2005	CD
cord-022353-q2k2krnm	1311	30	)	)	-RRB-
cord-022353-q2k2krnm	1311	31	.	.	.
cord-022353-q2k2krnm	1312	1	Bile	bile	NN
cord-022353-q2k2krnm	1312	2	acids	acid	NNS
cord-022353-q2k2krnm	1312	3	are	be	VBP
cord-022353-q2k2krnm	1312	4	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1312	5	breakdown	breakdown	NN
cord-022353-q2k2krnm	1312	6	products	product	NNS
cord-022353-q2k2krnm	1312	7	that	that	WDT
cord-022353-q2k2krnm	1312	8	are	be	VBP
cord-022353-q2k2krnm	1312	9	secreted	secrete	VBN
cord-022353-q2k2krnm	1312	10	by	by	IN
cord-022353-q2k2krnm	1312	11	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	1312	12	into	into	IN
cord-022353-q2k2krnm	1312	13	the	the	DT
cord-022353-q2k2krnm	1312	14	hepatobiliary	hepatobiliary	JJ
cord-022353-q2k2krnm	1312	15	system	system	NN
cord-022353-q2k2krnm	1312	16	,	,	,
cord-022353-q2k2krnm	1312	17	and	and	CC
cord-022353-q2k2krnm	1312	18	ultimately	ultimately	RB
cord-022353-q2k2krnm	1312	19	into	into	IN
cord-022353-q2k2krnm	1312	20	the	the	DT
cord-022353-q2k2krnm	1312	21	intestinal	intestinal	JJ
cord-022353-q2k2krnm	1312	22	tract	tract	NN
cord-022353-q2k2krnm	1312	23	.	.	.
cord-022353-q2k2krnm	1313	1	Bile	bile	NN
cord-022353-q2k2krnm	1313	2	acids	acid	NNS
cord-022353-q2k2krnm	1313	3	aid	aid	VBP
cord-022353-q2k2krnm	1313	4	digestion	digestion	NN
cord-022353-q2k2krnm	1313	5	by	by	IN
cord-022353-q2k2krnm	1313	6	emulsifying	emulsify	VBG
cord-022353-q2k2krnm	1313	7	dietary	dietary	JJ
cord-022353-q2k2krnm	1313	8	lipid	lipid	NN
cord-022353-q2k2krnm	1313	9	aggregates	aggregate	NNS
cord-022353-q2k2krnm	1313	10	,	,	,
cord-022353-q2k2krnm	1313	11	and	and	CC
cord-022353-q2k2krnm	1313	12	solubilizing	solubilize	VBG
cord-022353-q2k2krnm	1313	13	and	and	CC
cord-022353-q2k2krnm	1313	14	transporting	transport	VBG
cord-022353-q2k2krnm	1313	15	lipids	lipid	NNS
cord-022353-q2k2krnm	1313	16	in	in	IN
cord-022353-q2k2krnm	1313	17	an	an	DT
cord-022353-q2k2krnm	1313	18	aqueous	aqueous	JJ
cord-022353-q2k2krnm	1313	19	environment	environment	NN
cord-022353-q2k2krnm	1313	20	(	(	-LRB-
cord-022353-q2k2krnm	1313	21	in	in	IN
cord-022353-q2k2krnm	1313	22	particular	particular	JJ
cord-022353-q2k2krnm	1313	23	fat	fat	NN
cord-022353-q2k2krnm	1313	24	-	-	HYPH
cord-022353-q2k2krnm	1313	25	soluble	soluble	JJ
cord-022353-q2k2krnm	1313	26	vitamins	vitamin	NNS
cord-022353-q2k2krnm	1313	27	)	)	-RRB-
cord-022353-q2k2krnm	1313	28	.	.	.
cord-022353-q2k2krnm	1314	1	In	in	IN
cord-022353-q2k2krnm	1314	2	the	the	DT
cord-022353-q2k2krnm	1314	3	liver	liver	NN
cord-022353-q2k2krnm	1314	4	,	,	,
cord-022353-q2k2krnm	1314	5	bile	bile	NN
cord-022353-q2k2krnm	1314	6	acids	acid	NNS
cord-022353-q2k2krnm	1314	7	also	also	RB
cord-022353-q2k2krnm	1314	8	play	play	VBP
cord-022353-q2k2krnm	1314	9	a	a	DT
cord-022353-q2k2krnm	1314	10	role	role	NN
cord-022353-q2k2krnm	1314	11	regulating	regulate	VBG
cord-022353-q2k2krnm	1314	12	the	the	DT
cord-022353-q2k2krnm	1314	13	secretion	secretion	NN
cord-022353-q2k2krnm	1314	14	of	of	IN
cord-022353-q2k2krnm	1314	15	apolipoprotein	apolipoprotein	NN
cord-022353-q2k2krnm	1314	16	B	B	NNP
cord-022353-q2k2krnm	1314	17	(	(	-LRB-
cord-022353-q2k2krnm	1314	18	Elzinga	Elzinga	NNP
cord-022353-q2k2krnm	1314	19	et	et	NNP
cord-022353-q2k2krnm	1314	20	al	al	NNP
cord-022353-q2k2krnm	1314	21	.	.	NNP
cord-022353-q2k2krnm	1314	22	2003	2003	CD
cord-022353-q2k2krnm	1314	23	)	)	-RRB-
cord-022353-q2k2krnm	1314	24	.	.	.
cord-022353-q2k2krnm	1315	1	Extensive	extensive	JJ
cord-022353-q2k2krnm	1315	2	enterohepatic	enterohepatic	JJ
cord-022353-q2k2krnm	1315	3	recirculation	recirculation	NN
cord-022353-q2k2krnm	1315	4	results	result	NNS
cord-022353-q2k2krnm	1315	5	in	in	IN
cord-022353-q2k2krnm	1315	6	almost	almost	RB
cord-022353-q2k2krnm	1315	7	99	99	CD
cord-022353-q2k2krnm	1315	8	%	%	NN
cord-022353-q2k2krnm	1315	9	return	return	NN
cord-022353-q2k2krnm	1315	10	of	of	IN
cord-022353-q2k2krnm	1315	11	bile	bile	NN
cord-022353-q2k2krnm	1315	12	acids	acid	NNS
cord-022353-q2k2krnm	1315	13	secreted	secrete	VBN
cord-022353-q2k2krnm	1315	14	by	by	IN
cord-022353-q2k2krnm	1315	15	the	the	DT
cord-022353-q2k2krnm	1315	16	liver	liver	NN
cord-022353-q2k2krnm	1315	17	from	from	IN
cord-022353-q2k2krnm	1315	18	the	the	DT
cord-022353-q2k2krnm	1315	19	intestinal	intestinal	JJ
cord-022353-q2k2krnm	1315	20	tract	tract	NN
cord-022353-q2k2krnm	1315	21	.	.	.
cord-022353-q2k2krnm	1316	1	Absorption	absorption	NN
cord-022353-q2k2krnm	1316	2	occurs	occur	VBZ
cord-022353-q2k2krnm	1316	3	mainly	mainly	RB
cord-022353-q2k2krnm	1316	4	in	in	IN
cord-022353-q2k2krnm	1316	5	the	the	DT
cord-022353-q2k2krnm	1316	6	ileum	ileum	NN
cord-022353-q2k2krnm	1316	7	under	under	IN
cord-022353-q2k2krnm	1316	8	the	the	DT
cord-022353-q2k2krnm	1316	9	influence	influence	NN
cord-022353-q2k2krnm	1316	10	of	of	IN
cord-022353-q2k2krnm	1316	11	the	the	DT
cord-022353-q2k2krnm	1316	12	apical	apical	JJ
cord-022353-q2k2krnm	1316	13	Na	Na	NNP
cord-022353-q2k2krnm	1316	14	§	§	,
cord-022353-q2k2krnm	1316	15	bile	bile	NN
cord-022353-q2k2krnm	1316	16	acid	acid	NN
cord-022353-q2k2krnm	1316	17	transporter	transporter	NN
cord-022353-q2k2krnm	1316	18	on	on	IN
cord-022353-q2k2krnm	1316	19	epithelial	epithelial	JJ
cord-022353-q2k2krnm	1316	20	cells	cell	NNS
cord-022353-q2k2krnm	1316	21	(	(	-LRB-
cord-022353-q2k2krnm	1316	22	Kida	Kida	NNP
cord-022353-q2k2krnm	1316	23	et	et	NNP
cord-022353-q2k2krnm	1316	24	al	al	NNP
cord-022353-q2k2krnm	1316	25	.	.	NNP
cord-022353-q2k2krnm	1316	26	2003	2003	CD
cord-022353-q2k2krnm	1316	27	)	)	-RRB-
cord-022353-q2k2krnm	1316	28	.	.	.
cord-022353-q2k2krnm	1317	1	Some	some	DT
cord-022353-q2k2krnm	1317	2	absorption	absorption	NN
cord-022353-q2k2krnm	1317	3	also	also	RB
cord-022353-q2k2krnm	1317	4	takes	take	VBZ
cord-022353-q2k2krnm	1317	5	place	place	NN
cord-022353-q2k2krnm	1317	6	in	in	IN
cord-022353-q2k2krnm	1317	7	the	the	DT
cord-022353-q2k2krnm	1317	8	large	large	JJ
cord-022353-q2k2krnm	1317	9	intestine	intestine	NN
cord-022353-q2k2krnm	1317	10	.	.	.
cord-022353-q2k2krnm	1318	1	Absorbed	absorb	VBN
cord-022353-q2k2krnm	1318	2	conjugated	conjugated	JJ
cord-022353-q2k2krnm	1318	3	bile	bile	NN
cord-022353-q2k2krnm	1318	4	acids	acid	NNS
cord-022353-q2k2krnm	1318	5	(	(	-LRB-
cord-022353-q2k2krnm	1318	6	from	from	IN
cord-022353-q2k2krnm	1318	7	ileum	ileum	NN
cord-022353-q2k2krnm	1318	8	)	)	-RRB-
cord-022353-q2k2krnm	1318	9	pass	pass	VB
cord-022353-q2k2krnm	1318	10	unaltered	unaltered	JJ
cord-022353-q2k2krnm	1318	11	to	to	IN
cord-022353-q2k2krnm	1318	12	the	the	DT
cord-022353-q2k2krnm	1318	13	portal	portal	JJ
cord-022353-q2k2krnm	1318	14	circulation	circulation	NN
cord-022353-q2k2krnm	1318	15	where	where	WRB
cord-022353-q2k2krnm	1318	16	they	-PRON-	PRP
cord-022353-q2k2krnm	1318	17	are	be	VBP
cord-022353-q2k2krnm	1318	18	removed	remove	VBN
cord-022353-q2k2krnm	1318	19	by	by	IN
cord-022353-q2k2krnm	1318	20	Na+-taurocholate	Na+-taurocholate	NNP
cord-022353-q2k2krnm	1318	21	cotransporting	cotransporte	VBG
cord-022353-q2k2krnm	1318	22	polypeptide	polypeptide	NN
cord-022353-q2k2krnm	1318	23	located	locate	VBN
cord-022353-q2k2krnm	1318	24	on	on	IN
cord-022353-q2k2krnm	1318	25	the	the	DT
cord-022353-q2k2krnm	1318	26	basolateral	basolateral	JJ
cord-022353-q2k2krnm	1318	27	hepatocyte	hepatocyte	NN
cord-022353-q2k2krnm	1318	28	membrane	membrane	NN
cord-022353-q2k2krnm	1319	1	(	(	-LRB-
cord-022353-q2k2krnm	1319	2	Jung	Jung	NNP
cord-022353-q2k2krnm	1319	3	et	et	NNP
cord-022353-q2k2krnm	1319	4	aL	aL	NNP
cord-022353-q2k2krnm	1319	5	2004	2004	CD
cord-022353-q2k2krnm	1319	6	)	)	-RRB-
cord-022353-q2k2krnm	1319	7	.	.	.
cord-022353-q2k2krnm	1320	1	There	there	EX
cord-022353-q2k2krnm	1320	2	are	be	VBP
cord-022353-q2k2krnm	1320	3	two	two	CD
cord-022353-q2k2krnm	1320	4	types	type	NNS
cord-022353-q2k2krnm	1320	5	of	of	IN
cord-022353-q2k2krnm	1320	6	bile	bile	NN
cord-022353-q2k2krnm	1320	7	acids	acid	NNS
cord-022353-q2k2krnm	1320	8	,	,	,
cord-022353-q2k2krnm	1320	9	cholic	cholic	JJ
cord-022353-q2k2krnm	1320	10	acid	acid	NN
cord-022353-q2k2krnm	1320	11	and	and	CC
cord-022353-q2k2krnm	1320	12	chenodeoxycholic	chenodeoxycholic	JJ
cord-022353-q2k2krnm	1320	13	acid	acid	NN
cord-022353-q2k2krnm	1320	14	.	.	.
cord-022353-q2k2krnm	1321	1	In	in	IN
cord-022353-q2k2krnm	1321	2	mice	mouse	NNS
cord-022353-q2k2krnm	1321	3	,	,	,
cord-022353-q2k2krnm	1321	4	they	-PRON-	PRP
cord-022353-q2k2krnm	1321	5	are	be	VBP
cord-022353-q2k2krnm	1321	6	conjugated	conjugate	VBN
cord-022353-q2k2krnm	1321	7	with	with	IN
cord-022353-q2k2krnm	1321	8	taurine	taurine	NN
cord-022353-q2k2krnm	1321	9	before	before	IN
cord-022353-q2k2krnm	1321	10	secretion	secretion	NN
cord-022353-q2k2krnm	1321	11	by	by	IN
cord-022353-q2k2krnm	1321	12	the	the	DT
cord-022353-q2k2krnm	1321	13	liver	liver	NN
cord-022353-q2k2krnm	1321	14	.	.	.
cord-022353-q2k2krnm	1322	1	The	the	DT
cord-022353-q2k2krnm	1322	2	liver	liver	NN
cord-022353-q2k2krnm	1322	3	-	-	HYPH
cord-022353-q2k2krnm	1322	4	specific	specific	JJ
cord-022353-q2k2krnm	1322	5	enzymes	enzyme	NNS
cord-022353-q2k2krnm	1322	6	,	,	,
cord-022353-q2k2krnm	1322	7	bile	bile	NN
cord-022353-q2k2krnm	1322	8	acid	acid	NN
cord-022353-q2k2krnm	1322	9	CoA	coa	NN
cord-022353-q2k2krnm	1322	10	ligase	ligase	NN
cord-022353-q2k2krnm	1322	11	and	and	CC
cord-022353-q2k2krnm	1322	12	bile	bile	NN
cord-022353-q2k2krnm	1322	13	acid	acid	NN
cord-022353-q2k2krnm	1322	14	-	-	HYPH
cord-022353-q2k2krnm	1322	15	CoA	coa	NN
cord-022353-q2k2krnm	1322	16	:	:	:
cord-022353-q2k2krnm	1322	17	amino	amino	NN
cord-022353-q2k2krnm	1322	18	acid	acid	NN
cord-022353-q2k2krnm	1322	19	N	N	NNP
cord-022353-q2k2krnm	1322	20	-	-	HYPH
cord-022353-q2k2krnm	1322	21	acyltransferase	acyltransferase	NNP
cord-022353-q2k2krnm	1322	22	,	,	,
cord-022353-q2k2krnm	1322	23	are	be	VBP
cord-022353-q2k2krnm	1322	24	responsible	responsible	JJ
cord-022353-q2k2krnm	1322	25	for	for	IN
cord-022353-q2k2krnm	1322	26	conjugation	conjugation	NN
cord-022353-q2k2krnm	1322	27	(	(	-LRB-
cord-022353-q2k2krnm	1322	28	Inoue	Inoue	NNP
cord-022353-q2k2krnm	1322	29	et	et	NNP
cord-022353-q2k2krnm	1322	30	al	al	NNP
cord-022353-q2k2krnm	1322	31	.	.	.
cord-022353-q2k2krnm	1322	32	2004	2004	CD
cord-022353-q2k2krnm	1322	33	)	)	-RRB-
cord-022353-q2k2krnm	1322	34	.	.	.
cord-022353-q2k2krnm	1323	1	Stedman	Stedman	NNP
cord-022353-q2k2krnm	1323	2	et	et	NNP
cord-022353-q2k2krnm	1323	3	al	al	NNP
cord-022353-q2k2krnm	1323	4	.	.	.
cord-022353-q2k2krnm	1324	1	(	(	-LRB-
cord-022353-q2k2krnm	1324	2	2004	2004	CD
cord-022353-q2k2krnm	1324	3	)	)	-RRB-
cord-022353-q2k2krnm	1324	4	described	describe	VBD
cord-022353-q2k2krnm	1324	5	normal	normal	JJ
cord-022353-q2k2krnm	1324	6	serum	serum	NN
cord-022353-q2k2krnm	1324	7	bile	bile	NN
cord-022353-q2k2krnm	1324	8	acid	acid	NN
cord-022353-q2k2krnm	1324	9	levels	level	NNS
cord-022353-q2k2krnm	1324	10	in	in	IN
cord-022353-q2k2krnm	1324	11	normal	normal	JJ
cord-022353-q2k2krnm	1324	12	and	and	CC
cord-022353-q2k2krnm	1324	13	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1324	14	mice	mouse	NNS
cord-022353-q2k2krnm	1324	15	.	.	.
cord-022353-q2k2krnm	1325	1	Elevated	elevated	JJ
cord-022353-q2k2krnm	1325	2	serum	serum	NN
cord-022353-q2k2krnm	1325	3	bile	bile	NN
cord-022353-q2k2krnm	1325	4	acid	acid	NN
cord-022353-q2k2krnm	1325	5	levels	level	NNS
cord-022353-q2k2krnm	1325	6	in	in	IN
cord-022353-q2k2krnm	1325	7	mice	mouse	NNS
cord-022353-q2k2krnm	1325	8	is	be	VBZ
cord-022353-q2k2krnm	1325	9	usually	usually	RB
cord-022353-q2k2krnm	1325	10	due	due	JJ
cord-022353-q2k2krnm	1325	11	to	to	IN
cord-022353-q2k2krnm	1325	12	decreased	decrease	VBN
cord-022353-q2k2krnm	1325	13	bile	bile	NN
cord-022353-q2k2krnm	1325	14	acid	acid	NN
cord-022353-q2k2krnm	1325	15	recycling	recycling	NN
cord-022353-q2k2krnm	1325	16	by	by	IN
cord-022353-q2k2krnm	1325	17	the	the	DT
cord-022353-q2k2krnm	1325	18	liver	liver	NN
cord-022353-q2k2krnm	1325	19	,	,	,
cord-022353-q2k2krnm	1325	20	and	and	CC
cord-022353-q2k2krnm	1325	21	mainly	mainly	RB
cord-022353-q2k2krnm	1325	22	includes	include	VBZ
cord-022353-q2k2krnm	1325	23	diseases	disease	NNS
cord-022353-q2k2krnm	1325	24	associated	associate	VBN
cord-022353-q2k2krnm	1325	25	with	with	IN
cord-022353-q2k2krnm	1325	26	decreased	decrease	VBN
cord-022353-q2k2krnm	1325	27	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1325	28	functional	functional	JJ
cord-022353-q2k2krnm	1325	29	mass	mass	NN
cord-022353-q2k2krnm	1325	30	and	and	CC
cord-022353-q2k2krnm	1325	31	cholestasis	cholestasis	NN
cord-022353-q2k2krnm	1325	32	(	(	-LRB-
cord-022353-q2k2krnm	1325	33	Tennant	Tennant	NNP
cord-022353-q2k2krnm	1325	34	1999	1999	CD
cord-022353-q2k2krnm	1325	35	)	)	-RRB-
cord-022353-q2k2krnm	1325	36	.	.	.
cord-022353-q2k2krnm	1326	1	Hoda	Hoda	NNP
cord-022353-q2k2krnm	1326	2	and	and	CC
cord-022353-q2k2krnm	1326	3	Green	Green	NNP
cord-022353-q2k2krnm	1326	4	(	(	-LRB-
cord-022353-q2k2krnm	1326	5	2003	2003	CD
cord-022353-q2k2krnm	1326	6	)	)	-RRB-
cord-022353-q2k2krnm	1326	7	measured	measure	VBN
cord-022353-q2k2krnm	1326	8	increased	increase	VBN
cord-022353-q2k2krnm	1326	9	levels	level	NNS
cord-022353-q2k2krnm	1326	10	of	of	IN
cord-022353-q2k2krnm	1326	11	serum	serum	NN
cord-022353-q2k2krnm	1326	12	bile	bile	NN
cord-022353-q2k2krnm	1326	13	acids	acid	NNS
cord-022353-q2k2krnm	1326	14	after	after	IN
cord-022353-q2k2krnm	1326	15	bile	bile	NN
cord-022353-q2k2krnm	1326	16	duct	duct	NN
cord-022353-q2k2krnm	1326	17	ligation	ligation	NN
cord-022353-q2k2krnm	1326	18	.	.	.
cord-022353-q2k2krnm	1327	1	Albumin	albumin	NN
cord-022353-q2k2krnm	1327	2	is	be	VBZ
cord-022353-q2k2krnm	1327	3	a	a	DT
cord-022353-q2k2krnm	1327	4	nonglycosylated	nonglycosylated	JJ
cord-022353-q2k2krnm	1327	5	protein	protein	NN
cord-022353-q2k2krnm	1327	6	and	and	CC
cord-022353-q2k2krnm	1327	7	is	be	VBZ
cord-022353-q2k2krnm	1327	8	the	the	DT
cord-022353-q2k2krnm	1327	9	most	most	RBS
cord-022353-q2k2krnm	1327	10	abundant	abundant	JJ
cord-022353-q2k2krnm	1327	11	protein	protein	NN
cord-022353-q2k2krnm	1327	12	in	in	IN
cord-022353-q2k2krnm	1327	13	plasma	plasma	NN
cord-022353-q2k2krnm	1327	14	.	.	.
cord-022353-q2k2krnm	1328	1	It	-PRON-	PRP
cord-022353-q2k2krnm	1328	2	serves	serve	VBZ
cord-022353-q2k2krnm	1328	3	as	as	IN
cord-022353-q2k2krnm	1328	4	the	the	DT
cord-022353-q2k2krnm	1328	5	most	most	RBS
cord-022353-q2k2krnm	1328	6	important	important	JJ
cord-022353-q2k2krnm	1328	7	determinant	determinant	NN
cord-022353-q2k2krnm	1328	8	of	of	IN
cord-022353-q2k2krnm	1328	9	plasma	plasma	NN
cord-022353-q2k2krnm	1328	10	oncotic	oncotic	JJ
cord-022353-q2k2krnm	1328	11	pressure	pressure	NN
cord-022353-q2k2krnm	1328	12	,	,	,
cord-022353-q2k2krnm	1328	13	and	and	CC
cord-022353-q2k2krnm	1328	14	it	-PRON-	PRP
cord-022353-q2k2krnm	1328	15	is	be	VBZ
cord-022353-q2k2krnm	1328	16	a	a	DT
cord-022353-q2k2krnm	1328	17	major	major	JJ
cord-022353-q2k2krnm	1328	18	transport	transport	NN
cord-022353-q2k2krnm	1328	19	protein	protein	NN
cord-022353-q2k2krnm	1328	20	for	for	IN
cord-022353-q2k2krnm	1328	21	both	both	DT
cord-022353-q2k2krnm	1328	22	endogenous	endogenous	JJ
cord-022353-q2k2krnm	1328	23	metabolites	metabolite	NNS
cord-022353-q2k2krnm	1328	24	and	and	CC
cord-022353-q2k2krnm	1328	25	xenobiotics	xenobiotic	NNS
cord-022353-q2k2krnm	1328	26	.	.	.
cord-022353-q2k2krnm	1329	1	It	-PRON-	PRP
cord-022353-q2k2krnm	1329	2	is	be	VBZ
cord-022353-q2k2krnm	1329	3	made	make	VBN
cord-022353-q2k2krnm	1329	4	exclusively	exclusively	RB
cord-022353-q2k2krnm	1329	5	by	by	IN
cord-022353-q2k2krnm	1329	6	the	the	DT
cord-022353-q2k2krnm	1329	7	liver	liver	NN
cord-022353-q2k2krnm	1329	8	.	.	.
cord-022353-q2k2krnm	1330	1	Serum	serum	NN
cord-022353-q2k2krnm	1330	2	albumin	albumin	NN
cord-022353-q2k2krnm	1330	3	may	may	MD
cord-022353-q2k2krnm	1330	4	be	be	VB
cord-022353-q2k2krnm	1330	5	measured	measure	VBN
cord-022353-q2k2krnm	1330	6	by	by	IN
cord-022353-q2k2krnm	1330	7	radial	radial	NNP
cord-022353-q2k2krnm	1330	8	immunodiffusion	immunodiffusion	NN
cord-022353-q2k2krnm	1330	9	,	,	,
cord-022353-q2k2krnm	1330	10	dye	dye	NN
cord-022353-q2k2krnm	1330	11	binding	binding	NN
cord-022353-q2k2krnm	1330	12	reactions	reaction	NNS
cord-022353-q2k2krnm	1330	13	(	(	-LRB-
cord-022353-q2k2krnm	1330	14	using	use	VBG
cord-022353-q2k2krnm	1330	15	bromcresol	bromcresol	NNP
cord-022353-q2k2krnm	1330	16	green	green	NNP
cord-022353-q2k2krnm	1330	17	or	or	CC
cord-022353-q2k2krnm	1330	18	bromcresol	bromcresol	NNP
cord-022353-q2k2krnm	1330	19	purple	purple	NNP
cord-022353-q2k2krnm	1330	20	)	)	-RRB-
cord-022353-q2k2krnm	1330	21	,	,	,
cord-022353-q2k2krnm	1330	22	electrophoresis	electrophoresis	NN
cord-022353-q2k2krnm	1330	23	,	,	,
cord-022353-q2k2krnm	1330	24	and	and	CC
cord-022353-q2k2krnm	1330	25	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1330	26	.	.	.
cord-022353-q2k2krnm	1331	1	Serum	serum	NN
cord-022353-q2k2krnm	1331	2	albumin	albumin	NN
cord-022353-q2k2krnm	1331	3	levels	level	NNS
cord-022353-q2k2krnm	1331	4	decrease	decrease	VBP
cord-022353-q2k2krnm	1331	5	with	with	IN
cord-022353-q2k2krnm	1331	6	age	age	NN
cord-022353-q2k2krnm	1331	7	in	in	IN
cord-022353-q2k2krnm	1331	8	many	many	JJ
cord-022353-q2k2krnm	1331	9	inbred	inbred	JJ
cord-022353-q2k2krnm	1331	10	strains	strain	NNS
cord-022353-q2k2krnm	1331	11	(	(	-LRB-
cord-022353-q2k2krnm	1331	12	Quimby	Quimby	NNP
cord-022353-q2k2krnm	1331	13	1999b	1999b	CD
cord-022353-q2k2krnm	1331	14	)	)	-RRB-
cord-022353-q2k2krnm	1331	15	.	.	.
cord-022353-q2k2krnm	1332	1	Hypoalbuminemia	Hypoalbuminemia	NNP
cord-022353-q2k2krnm	1332	2	is	be	VBZ
cord-022353-q2k2krnm	1332	3	usually	usually	RB
cord-022353-q2k2krnm	1332	4	reflective	reflective	JJ
cord-022353-q2k2krnm	1332	5	of	of	IN
cord-022353-q2k2krnm	1332	6	decreased	decreased	JJ
cord-022353-q2k2krnm	1332	7	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1332	8	synthesis	synthesis	NN
cord-022353-q2k2krnm	1332	9	(	(	-LRB-
cord-022353-q2k2krnm	1332	10	due	due	IN
cord-022353-q2k2krnm	1332	11	to	to	IN
cord-022353-q2k2krnm	1332	12	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1332	13	disease	disease	NN
cord-022353-q2k2krnm	1332	14	,	,	,
cord-022353-q2k2krnm	1332	15	inflammation	inflammation	NN
cord-022353-q2k2krnm	1332	16	,	,	,
cord-022353-q2k2krnm	1332	17	and	and	CC
cord-022353-q2k2krnm	1332	18	malabsorptive	malabsorptive	JJ
cord-022353-q2k2krnm	1332	19	/	/	SYM
cord-022353-q2k2krnm	1332	20	maldigestive	maldigestive	JJ
cord-022353-q2k2krnm	1332	21	diseases	disease	NNS
cord-022353-q2k2krnm	1332	22	)	)	-RRB-
cord-022353-q2k2krnm	1332	23	,	,	,
cord-022353-q2k2krnm	1332	24	increased	increase	VBN
cord-022353-q2k2krnm	1332	25	loss	loss	NN
cord-022353-q2k2krnm	1332	26	due	due	IN
cord-022353-q2k2krnm	1332	27	to	to	IN
cord-022353-q2k2krnm	1332	28	hemorrhage	hemorrhage	NN
cord-022353-q2k2krnm	1332	29	or	or	CC
cord-022353-q2k2krnm	1332	30	via	via	IN
cord-022353-q2k2krnm	1332	31	the	the	DT
cord-022353-q2k2krnm	1332	32	intestinal	intestinal	JJ
cord-022353-q2k2krnm	1332	33	tract	tract	NN
cord-022353-q2k2krnm	1332	34	(	(	-LRB-
cord-022353-q2k2krnm	1332	35	protein	protein	NN
cord-022353-q2k2krnm	1332	36	-	-	HYPH
cord-022353-q2k2krnm	1332	37	losing	lose	VBG
cord-022353-q2k2krnm	1332	38	enteropathies	enteropathy	NNS
cord-022353-q2k2krnm	1332	39	)	)	-RRB-
cord-022353-q2k2krnm	1332	40	and	and	CC
cord-022353-q2k2krnm	1332	41	kidneys	kidney	NNS
cord-022353-q2k2krnm	1332	42	(	(	-LRB-
cord-022353-q2k2krnm	1332	43	protein	protein	NN
cord-022353-q2k2krnm	1332	44	-	-	HYPH
cord-022353-q2k2krnm	1332	45	losing	lose	VBG
cord-022353-q2k2krnm	1332	46	nephropathies	nephropathy	NNS
cord-022353-q2k2krnm	1332	47	)	)	-RRB-
cord-022353-q2k2krnm	1332	48	(	(	-LRB-
cord-022353-q2k2krnm	1332	49	Tennant	Tennant	NNP
cord-022353-q2k2krnm	1332	50	1999	1999	CD
cord-022353-q2k2krnm	1332	51	)	)	-RRB-
cord-022353-q2k2krnm	1332	52	.	.	.
cord-022353-q2k2krnm	1333	1	Most	Most	JJS
cord-022353-q2k2krnm	1333	2	of	of	IN
cord-022353-q2k2krnm	1333	3	the	the	DT
cord-022353-q2k2krnm	1333	4	proteins	protein	NNS
cord-022353-q2k2krnm	1333	5	associated	associate	VBN
cord-022353-q2k2krnm	1333	6	with	with	IN
cord-022353-q2k2krnm	1333	7	coagulation	coagulation	NN
cord-022353-q2k2krnm	1333	8	are	be	VBP
cord-022353-q2k2krnm	1333	9	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1333	10	by	by	IN
cord-022353-q2k2krnm	1333	11	the	the	DT
cord-022353-q2k2krnm	1333	12	liver	liver	NN
cord-022353-q2k2krnm	1333	13	(	(	-LRB-
cord-022353-q2k2krnm	1333	14	except	except	IN
cord-022353-q2k2krnm	1333	15	factor	factor	NN
cord-022353-q2k2krnm	1333	16	VIII	VIII	NNP
cord-022353-q2k2krnm	1333	17	)	)	-RRB-
cord-022353-q2k2krnm	1333	18	,	,	,
cord-022353-q2k2krnm	1333	19	and	and	CC
cord-022353-q2k2krnm	1333	20	measurement	measurement	NN
cord-022353-q2k2krnm	1333	21	of	of	IN
cord-022353-q2k2krnm	1333	22	fibrinogen	fibrinogen	NN
cord-022353-q2k2krnm	1333	23	or	or	CC
cord-022353-q2k2krnm	1333	24	prothrombin	prothrombin	NN
cord-022353-q2k2krnm	1333	25	time	time	NN
cord-022353-q2k2krnm	1333	26	has	have	VBZ
cord-022353-q2k2krnm	1333	27	served	serve	VBN
cord-022353-q2k2krnm	1333	28	as	as	IN
cord-022353-q2k2krnm	1333	29	a	a	DT
cord-022353-q2k2krnm	1333	30	marker	marker	NN
cord-022353-q2k2krnm	1333	31	for	for	IN
cord-022353-q2k2krnm	1333	32	decreased	decreased	JJ
cord-022353-q2k2krnm	1333	33	synthesis	synthesis	NN
cord-022353-q2k2krnm	1333	34	due	due	IN
cord-022353-q2k2krnm	1333	35	to	to	IN
cord-022353-q2k2krnm	1333	36	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1333	37	injury	injury	NN
cord-022353-q2k2krnm	1333	38	(	(	-LRB-
cord-022353-q2k2krnm	1333	39	Tennant	Tennant	NNP
cord-022353-q2k2krnm	1333	40	1999	1999	CD
cord-022353-q2k2krnm	1333	41	)	)	-RRB-
cord-022353-q2k2krnm	1333	42	.	.	.
cord-022353-q2k2krnm	1334	1	Prothrombin	Prothrombin	NNP
cord-022353-q2k2krnm	1334	2	time	time	NN
cord-022353-q2k2krnm	1334	3	will	will	MD
cord-022353-q2k2krnm	1334	4	also	also	RB
cord-022353-q2k2krnm	1334	5	be	be	VB
cord-022353-q2k2krnm	1334	6	increased	increase	VBN
cord-022353-q2k2krnm	1334	7	due	due	IN
cord-022353-q2k2krnm	1334	8	to	to	IN
cord-022353-q2k2krnm	1334	9	consumption	consumption	NN
cord-022353-q2k2krnm	1334	10	of	of	IN
cord-022353-q2k2krnm	1334	11	clotting	clot	VBG
cord-022353-q2k2krnm	1334	12	components	component	NNS
cord-022353-q2k2krnm	1334	13	and	and	CC
cord-022353-q2k2krnm	1334	14	in	in	IN
cord-022353-q2k2krnm	1334	15	vitamin	vitamin	NN
cord-022353-q2k2krnm	1334	16	K	K	NNP
cord-022353-q2k2krnm	1334	17	deficiency	deficiency	NN
cord-022353-q2k2krnm	1334	18	.	.	.
cord-022353-q2k2krnm	1335	1	Fibrinogen	fibrinogen	NN
cord-022353-q2k2krnm	1335	2	is	be	VBZ
cord-022353-q2k2krnm	1335	3	also	also	RB
cord-022353-q2k2krnm	1335	4	an	an	DT
cord-022353-q2k2krnm	1335	5	acute	acute	JJ
cord-022353-q2k2krnm	1335	6	phase	phase	NN
cord-022353-q2k2krnm	1335	7	reactant	reactant	NN
cord-022353-q2k2krnm	1335	8	,	,	,
cord-022353-q2k2krnm	1335	9	and	and	CC
cord-022353-q2k2krnm	1335	10	plasma	plasma	NN
cord-022353-q2k2krnm	1335	11	elevations	elevation	NNS
cord-022353-q2k2krnm	1335	12	are	be	VBP
cord-022353-q2k2krnm	1335	13	seen	see	VBN
cord-022353-q2k2krnm	1335	14	during	during	IN
cord-022353-q2k2krnm	1335	15	inflammation	inflammation	NN
cord-022353-q2k2krnm	1335	16	(	(	-LRB-
cord-022353-q2k2krnm	1335	17	Tennant	Tennant	NNP
cord-022353-q2k2krnm	1335	18	1999	1999	CD
cord-022353-q2k2krnm	1335	19	)	)	-RRB-
cord-022353-q2k2krnm	1335	20	.	.	.
cord-022353-q2k2krnm	1336	1	Fibrinogen	fibrinogen	NN
cord-022353-q2k2krnm	1336	2	may	may	MD
cord-022353-q2k2krnm	1336	3	be	be	VB
cord-022353-q2k2krnm	1336	4	quantified	quantify	VBN
cord-022353-q2k2krnm	1336	5	in	in	IN
cord-022353-q2k2krnm	1336	6	mouse	mouse	NN
cord-022353-q2k2krnm	1336	7	plasma	plasma	NN
cord-022353-q2k2krnm	1336	8	by	by	IN
cord-022353-q2k2krnm	1336	9	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1336	10	.	.	.
cord-022353-q2k2krnm	1337	1	Ceruloplasmin	Ceruloplasmin	NNP
cord-022353-q2k2krnm	1337	2	is	be	VBZ
cord-022353-q2k2krnm	1337	3	copper	copper	NN
cord-022353-q2k2krnm	1337	4	-	-	HYPH
cord-022353-q2k2krnm	1337	5	containing	contain	VBG
cord-022353-q2k2krnm	1337	6	acute	acute	JJ
cord-022353-q2k2krnm	1337	7	phase	phase	NN
cord-022353-q2k2krnm	1337	8	reactant	reactant	NN
cord-022353-q2k2krnm	1337	9	and	and	CC
cord-022353-q2k2krnm	1337	10	iron	iron	NN
cord-022353-q2k2krnm	1337	11	transport	transport	NN
cord-022353-q2k2krnm	1337	12	protein	protein	NN
cord-022353-q2k2krnm	1337	13	made	make	VBN
cord-022353-q2k2krnm	1337	14	exclusively	exclusively	RB
cord-022353-q2k2krnm	1337	15	in	in	IN
cord-022353-q2k2krnm	1337	16	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	1337	17	of	of	IN
cord-022353-q2k2krnm	1337	18	mice	mouse	NNS
cord-022353-q2k2krnm	1337	19	.	.	.
cord-022353-q2k2krnm	1338	1	Its	-PRON-	PRP$
cord-022353-q2k2krnm	1338	2	serum	serum	NN
cord-022353-q2k2krnm	1338	3	levels	level	NNS
cord-022353-q2k2krnm	1338	4	may	may	MD
cord-022353-q2k2krnm	1338	5	be	be	VB
cord-022353-q2k2krnm	1338	6	decreased	decrease	VBN
cord-022353-q2k2krnm	1338	7	during	during	IN
cord-022353-q2k2krnm	1338	8	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1338	9	injury	injury	NN
cord-022353-q2k2krnm	1338	10	and	and	CC
cord-022353-q2k2krnm	1338	11	increased	increase	VBD
cord-022353-q2k2krnm	1338	12	in	in	IN
cord-022353-q2k2krnm	1338	13	response	response	NN
cord-022353-q2k2krnm	1338	14	to	to	IN
cord-022353-q2k2krnm	1338	15	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	1338	16	stimuli	stimulus	NNS
cord-022353-q2k2krnm	1338	17	(	(	-LRB-
cord-022353-q2k2krnm	1338	18	Min	Min	NNP
cord-022353-q2k2krnm	1338	19	et	et	FW
cord-022353-q2k2krnm	1338	20	al	al	NNP
cord-022353-q2k2krnm	1338	21	.	.	NNP
cord-022353-q2k2krnm	1338	22	1991	1991	CD
cord-022353-q2k2krnm	1338	23	;	;	:
cord-022353-q2k2krnm	1338	24	Shim	Shim	NNP
cord-022353-q2k2krnm	1338	25	and	and	CC
cord-022353-q2k2krnm	1338	26	Harris	Harris	NNP
cord-022353-q2k2krnm	1338	27	2003	2003	CD
cord-022353-q2k2krnm	1338	28	)	)	-RRB-
cord-022353-q2k2krnm	1338	29	.	.	.
cord-022353-q2k2krnm	1339	1	Many	many	JJ
cord-022353-q2k2krnm	1339	2	of	of	IN
cord-022353-q2k2krnm	1339	3	the	the	DT
cord-022353-q2k2krnm	1339	4	complement	complement	JJ
cord-022353-q2k2krnm	1339	5	components	component	NNS
cord-022353-q2k2krnm	1339	6	are	be	VBP
cord-022353-q2k2krnm	1339	7	also	also	RB
cord-022353-q2k2krnm	1339	8	made	make	VBN
cord-022353-q2k2krnm	1339	9	in	in	IN
cord-022353-q2k2krnm	1339	10	the	the	DT
cord-022353-q2k2krnm	1339	11	mouse	mouse	NN
cord-022353-q2k2krnm	1339	12	liver	liver	NN
cord-022353-q2k2krnm	1339	13	,	,	,
cord-022353-q2k2krnm	1339	14	especially	especially	RB
cord-022353-q2k2krnm	1339	15	C2	C2	NNP
cord-022353-q2k2krnm	1339	16	,	,	,
cord-022353-q2k2krnm	1339	17	C3	C3	NNP
cord-022353-q2k2krnm	1339	18	,	,	,
cord-022353-q2k2krnm	1339	19	C4	C4	NNP
cord-022353-q2k2krnm	1339	20	,	,	,
cord-022353-q2k2krnm	1339	21	and	and	CC
cord-022353-q2k2krnm	1339	22	factor	factor	NN
cord-022353-q2k2krnm	1339	23	B.	B.	NNP
cord-022353-q2k2krnm	1339	24	Decreased	decrease	VBD
cord-022353-q2k2krnm	1340	1	circulating	circulate	VBG
cord-022353-q2k2krnm	1340	2	levels	level	NNS
cord-022353-q2k2krnm	1340	3	may	may	MD
cord-022353-q2k2krnm	1340	4	be	be	VB
cord-022353-q2k2krnm	1340	5	seen	see	VBN
cord-022353-q2k2krnm	1340	6	due	due	IN
cord-022353-q2k2krnm	1340	7	to	to	IN
cord-022353-q2k2krnm	1340	8	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1340	9	injury	injury	NN
cord-022353-q2k2krnm	1340	10	or	or	CC
cord-022353-q2k2krnm	1340	11	due	due	IN
cord-022353-q2k2krnm	1340	12	to	to	IN
cord-022353-q2k2krnm	1340	13	consumption	consumption	NN
cord-022353-q2k2krnm	1340	14	during	during	IN
cord-022353-q2k2krnm	1340	15	activation	activation	NN
cord-022353-q2k2krnm	1340	16	.	.	.
cord-022353-q2k2krnm	1341	1	Please	please	UH
cord-022353-q2k2krnm	1341	2	refer	refer	VB
cord-022353-q2k2krnm	1341	3	to	to	IN
cord-022353-q2k2krnm	1341	4	the	the	DT
cord-022353-q2k2krnm	1341	5	"	"	``
cord-022353-q2k2krnm	1341	6	Complement	complement	NN
cord-022353-q2k2krnm	1341	7	"	"	''
cord-022353-q2k2krnm	1341	8	section	section	NN
cord-022353-q2k2krnm	1341	9	for	for	IN
cord-022353-q2k2krnm	1341	10	further	further	JJ
cord-022353-q2k2krnm	1341	11	details	detail	NNS
cord-022353-q2k2krnm	1341	12	on	on	IN
cord-022353-q2k2krnm	1341	13	complement	complement	JJ
cord-022353-q2k2krnm	1341	14	function	function	NN
cord-022353-q2k2krnm	1341	15	and	and	CC
cord-022353-q2k2krnm	1341	16	measurement	measurement	NN
cord-022353-q2k2krnm	1341	17	.	.	.
cord-022353-q2k2krnm	1342	1	Two	two	CD
cord-022353-q2k2krnm	1342	2	dyes	dye	NNS
cord-022353-q2k2krnm	1342	3	,	,	,
cord-022353-q2k2krnm	1342	4	sulfobromophthalein	sulfobromophthalein	NNP
cord-022353-q2k2krnm	1342	5	and	and	CC
cord-022353-q2k2krnm	1342	6	indocyanine	indocyanine	NNP
cord-022353-q2k2krnm	1342	7	green	green	NNP
cord-022353-q2k2krnm	1342	8	,	,	,
cord-022353-q2k2krnm	1342	9	have	have	VBP
cord-022353-q2k2krnm	1342	10	been	be	VBN
cord-022353-q2k2krnm	1342	11	used	use	VBN
cord-022353-q2k2krnm	1342	12	to	to	TO
cord-022353-q2k2krnm	1342	13	assess	assess	VB
cord-022353-q2k2krnm	1342	14	hepatocellular	hepatocellular	JJ
cord-022353-q2k2krnm	1342	15	or	or	CC
cord-022353-q2k2krnm	1342	16	bile	bile	NN
cord-022353-q2k2krnm	1342	17	tract	tract	NN
cord-022353-q2k2krnm	1342	18	function	function	NN
cord-022353-q2k2krnm	1342	19	.	.	.
cord-022353-q2k2krnm	1343	1	Following	follow	VBG
cord-022353-q2k2krnm	1343	2	an	an	DT
cord-022353-q2k2krnm	1343	3	intravenous	intravenous	JJ
cord-022353-q2k2krnm	1343	4	bolus	bolus	NN
cord-022353-q2k2krnm	1343	5	,	,	,
cord-022353-q2k2krnm	1343	6	these	these	DT
cord-022353-q2k2krnm	1343	7	dyes	dye	NNS
cord-022353-q2k2krnm	1343	8	are	be	VBP
cord-022353-q2k2krnm	1343	9	rapidly	rapidly	RB
cord-022353-q2k2krnm	1343	10	cleared	clear	VBN
cord-022353-q2k2krnm	1343	11	from	from	IN
cord-022353-q2k2krnm	1343	12	the	the	DT
cord-022353-q2k2krnm	1343	13	plasma	plasma	NN
cord-022353-q2k2krnm	1343	14	by	by	IN
cord-022353-q2k2krnm	1343	15	hepatocytes	hepatocyte	NNS
cord-022353-q2k2krnm	1343	16	and	and	CC
cord-022353-q2k2krnm	1343	17	excreted	excrete	VBN
cord-022353-q2k2krnm	1343	18	into	into	IN
cord-022353-q2k2krnm	1343	19	the	the	DT
cord-022353-q2k2krnm	1343	20	bile	bile	NN
cord-022353-q2k2krnm	1343	21	.	.	.
cord-022353-q2k2krnm	1344	1	Both	both	DT
cord-022353-q2k2krnm	1344	2	dyes	dye	NNS
cord-022353-q2k2krnm	1344	3	have	have	VBP
cord-022353-q2k2krnm	1344	4	been	be	VBN
cord-022353-q2k2krnm	1344	5	used	use	VBN
cord-022353-q2k2krnm	1344	6	to	to	TO
cord-022353-q2k2krnm	1344	7	assess	assess	VB
cord-022353-q2k2krnm	1344	8	liver	liver	NN
cord-022353-q2k2krnm	1344	9	function	function	NN
cord-022353-q2k2krnm	1344	10	in	in	IN
cord-022353-q2k2krnm	1344	11	mice	mouse	NNS
cord-022353-q2k2krnm	1345	1	(	(	-LRB-
cord-022353-q2k2krnm	1345	2	Hurwitz	Hurwitz	NNP
cord-022353-q2k2krnm	1345	3	et	et	NNP
cord-022353-q2k2krnm	1345	4	al	al	NNP
cord-022353-q2k2krnm	1345	5	.	.	.
cord-022353-q2k2krnm	1345	6	1994	1994	CD
cord-022353-q2k2krnm	1345	7	;	;	:
cord-022353-q2k2krnm	1345	8	Huang	Huang	NNP
cord-022353-q2k2krnm	1345	9	and	and	CC
cord-022353-q2k2krnm	1345	10	Vore	Vore	NNP
cord-022353-q2k2krnm	1345	11	2001	2001	CD
cord-022353-q2k2krnm	1345	12	)	)	-RRB-
cord-022353-q2k2krnm	1345	13	.	.	.
cord-022353-q2k2krnm	1346	1	The	the	DT
cord-022353-q2k2krnm	1346	2	kidney	kidney	NN
cord-022353-q2k2krnm	1346	3	plays	play	VBZ
cord-022353-q2k2krnm	1346	4	a	a	DT
cord-022353-q2k2krnm	1346	5	complex	complex	JJ
cord-022353-q2k2krnm	1346	6	role	role	NN
cord-022353-q2k2krnm	1346	7	in	in	IN
cord-022353-q2k2krnm	1346	8	maintaining	maintain	VBG
cord-022353-q2k2krnm	1346	9	homeostasis	homeostasis	NN
cord-022353-q2k2krnm	1346	10	in	in	IN
cord-022353-q2k2krnm	1346	11	the	the	DT
cord-022353-q2k2krnm	1346	12	body	body	NN
cord-022353-q2k2krnm	1346	13	and	and	CC
cord-022353-q2k2krnm	1346	14	is	be	VBZ
cord-022353-q2k2krnm	1346	15	involved	involve	VBN
cord-022353-q2k2krnm	1346	16	in	in	IN
cord-022353-q2k2krnm	1346	17	such	such	JJ
cord-022353-q2k2krnm	1346	18	functions	function	NNS
cord-022353-q2k2krnm	1346	19	as	as	IN
cord-022353-q2k2krnm	1346	20	water	water	NN
cord-022353-q2k2krnm	1346	21	and	and	CC
cord-022353-q2k2krnm	1346	22	electrolyte	electrolyte	NN
cord-022353-q2k2krnm	1346	23	balance	balance	NN
cord-022353-q2k2krnm	1346	24	,	,	,
cord-022353-q2k2krnm	1346	25	nutrient	nutrient	NN
cord-022353-q2k2krnm	1346	26	conservation	conservation	NN
cord-022353-q2k2krnm	1346	27	,	,	,
cord-022353-q2k2krnm	1346	28	maintenance	maintenance	NN
cord-022353-q2k2krnm	1346	29	of	of	IN
cord-022353-q2k2krnm	1346	30	blood	blood	NN
cord-022353-q2k2krnm	1346	31	pH	ph	NN
cord-022353-q2k2krnm	1346	32	,	,	,
cord-022353-q2k2krnm	1346	33	and	and	CC
cord-022353-q2k2krnm	1346	34	removal	removal	NN
cord-022353-q2k2krnm	1346	35	of	of	IN
cord-022353-q2k2krnm	1346	36	the	the	DT
cord-022353-q2k2krnm	1346	37	end	end	NN
cord-022353-q2k2krnm	1346	38	products	product	NNS
cord-022353-q2k2krnm	1346	39	of	of	IN
cord-022353-q2k2krnm	1346	40	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1346	41	metabolism	metabolism	NN
cord-022353-q2k2krnm	1346	42	(	(	-LRB-
cord-022353-q2k2krnm	1346	43	such	such	JJ
cord-022353-q2k2krnm	1346	44	as	as	IN
cord-022353-q2k2krnm	1346	45	urea	urea	NN
cord-022353-q2k2krnm	1346	46	,	,	,
cord-022353-q2k2krnm	1346	47	creatinine	creatinine	NN
cord-022353-q2k2krnm	1346	48	,	,	,
cord-022353-q2k2krnm	1346	49	and	and	CC
cord-022353-q2k2krnm	1346	50	allantoin	allantoin	NN
cord-022353-q2k2krnm	1346	51	)	)	-RRB-
cord-022353-q2k2krnm	1346	52	.	.	.
cord-022353-q2k2krnm	1347	1	In	in	IN
cord-022353-q2k2krnm	1347	2	addition	addition	NN
cord-022353-q2k2krnm	1347	3	,	,	,
cord-022353-q2k2krnm	1347	4	the	the	DT
cord-022353-q2k2krnm	1347	5	kidney	kidney	NN
cord-022353-q2k2krnm	1347	6	produces	produce	VBZ
cord-022353-q2k2krnm	1347	7	and	and	CC
cord-022353-q2k2krnm	1347	8	responds	respond	VBZ
cord-022353-q2k2krnm	1347	9	to	to	IN
cord-022353-q2k2krnm	1347	10	a	a	DT
cord-022353-q2k2krnm	1347	11	variety	variety	NN
cord-022353-q2k2krnm	1347	12	of	of	IN
cord-022353-q2k2krnm	1347	13	hormones	hormone	NNS
cord-022353-q2k2krnm	1347	14	.	.	.
cord-022353-q2k2krnm	1348	1	However	however	RB
cord-022353-q2k2krnm	1348	2	,	,	,
cord-022353-q2k2krnm	1348	3	assessing	assess	VBG
cord-022353-q2k2krnm	1348	4	renal	renal	JJ
cord-022353-q2k2krnm	1348	5	function	function	NN
cord-022353-q2k2krnm	1348	6	is	be	VBZ
cord-022353-q2k2krnm	1348	7	complicated	complicate	VBN
cord-022353-q2k2krnm	1348	8	by	by	IN
cord-022353-q2k2krnm	1348	9	the	the	DT
cord-022353-q2k2krnm	1348	10	large	large	JJ
cord-022353-q2k2krnm	1348	11	functional	functional	JJ
cord-022353-q2k2krnm	1348	12	reserve	reserve	NN
cord-022353-q2k2krnm	1348	13	of	of	IN
cord-022353-q2k2krnm	1348	14	the	the	DT
cord-022353-q2k2krnm	1348	15	kidneys	kidney	NNS
cord-022353-q2k2krnm	1348	16	.	.	.
cord-022353-q2k2krnm	1349	1	For	for	IN
cord-022353-q2k2krnm	1349	2	instance	instance	NN
cord-022353-q2k2krnm	1349	3	,	,	,
cord-022353-q2k2krnm	1349	4	increases	increase	NNS
cord-022353-q2k2krnm	1349	5	in	in	IN
cord-022353-q2k2krnm	1349	6	urea	urea	NN
cord-022353-q2k2krnm	1349	7	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1349	8	do	do	VBP
cord-022353-q2k2krnm	1349	9	not	not	RB
cord-022353-q2k2krnm	1349	10	occur	occur	VB
cord-022353-q2k2krnm	1349	11	until	until	IN
cord-022353-q2k2krnm	1349	12	70	70	CD
cord-022353-q2k2krnm	1349	13	-	-	SYM
cord-022353-q2k2krnm	1349	14	75	75	CD
cord-022353-q2k2krnm	1349	15	%	%	NN
cord-022353-q2k2krnm	1349	16	of	of	IN
cord-022353-q2k2krnm	1349	17	renal	renal	JJ
cord-022353-q2k2krnm	1349	18	mass	mass	NN
cord-022353-q2k2krnm	1349	19	has	have	VBZ
cord-022353-q2k2krnm	1349	20	become	become	VBN
cord-022353-q2k2krnm	1349	21	functionally	functionally	RB
cord-022353-q2k2krnm	1349	22	compromised	compromised	JJ
cord-022353-q2k2krnm	1349	23	.	.	.
cord-022353-q2k2krnm	1350	1	Additionally	additionally	RB
cord-022353-q2k2krnm	1350	2	,	,	,
cord-022353-q2k2krnm	1350	3	assessment	assessment	NN
cord-022353-q2k2krnm	1350	4	of	of	IN
cord-022353-q2k2krnm	1350	5	analytes	analyte	NNS
cord-022353-q2k2krnm	1350	6	in	in	IN
cord-022353-q2k2krnm	1350	7	urine	urine	NN
cord-022353-q2k2krnm	1350	8	is	be	VBZ
cord-022353-q2k2krnm	1350	9	difficult	difficult	JJ
cord-022353-q2k2krnm	1350	10	due	due	IN
cord-022353-q2k2krnm	1350	11	to	to	IN
cord-022353-q2k2krnm	1350	12	the	the	DT
cord-022353-q2k2krnm	1350	13	small	small	JJ
cord-022353-q2k2krnm	1350	14	size	size	NN
cord-022353-q2k2krnm	1350	15	of	of	IN
cord-022353-q2k2krnm	1350	16	mice	mouse	NNS
cord-022353-q2k2krnm	1350	17	(	(	-LRB-
cord-022353-q2k2krnm	1350	18	as	as	IN
cord-022353-q2k2krnm	1350	19	discussed	discuss	VBN
cord-022353-q2k2krnm	1350	20	in	in	IN
cord-022353-q2k2krnm	1350	21	the	the	DT
cord-022353-q2k2krnm	1350	22	"	"	``
cord-022353-q2k2krnm	1350	23	Sampling	sampling	NN
cord-022353-q2k2krnm	1350	24	"	"	''
cord-022353-q2k2krnm	1350	25	section	section	NN
cord-022353-q2k2krnm	1350	26	)	)	-RRB-
cord-022353-q2k2krnm	1350	27	.	.	.
cord-022353-q2k2krnm	1351	1	Urea	urea	NN
cord-022353-q2k2krnm	1351	2	is	be	VBZ
cord-022353-q2k2krnm	1351	3	produced	produce	VBN
cord-022353-q2k2krnm	1351	4	in	in	IN
cord-022353-q2k2krnm	1351	5	the	the	DT
cord-022353-q2k2krnm	1351	6	liver	liver	NN
cord-022353-q2k2krnm	1351	7	as	as	IN
cord-022353-q2k2krnm	1351	8	a	a	DT
cord-022353-q2k2krnm	1351	9	waste	waste	NN
cord-022353-q2k2krnm	1351	10	product	product	NN
cord-022353-q2k2krnm	1351	11	of	of	IN
cord-022353-q2k2krnm	1351	12	protein	protein	NN
cord-022353-q2k2krnm	1351	13	catabolism	catabolism	NN
cord-022353-q2k2krnm	1351	14	(	(	-LRB-
cord-022353-q2k2krnm	1351	15	specifically	specifically	RB
cord-022353-q2k2krnm	1351	16	a	a	DT
cord-022353-q2k2krnm	1351	17	breakdown	breakdown	NN
cord-022353-q2k2krnm	1351	18	product	product	NN
cord-022353-q2k2krnm	1351	19	of	of	IN
cord-022353-q2k2krnm	1351	20	ammonia	ammonia	NN
cord-022353-q2k2krnm	1351	21	)	)	-RRB-
cord-022353-q2k2krnm	1351	22	.	.	.
cord-022353-q2k2krnm	1352	1	Urea	urea	NN
cord-022353-q2k2krnm	1352	2	is	be	VBZ
cord-022353-q2k2krnm	1352	3	a	a	DT
cord-022353-q2k2krnm	1352	4	small	small	JJ
cord-022353-q2k2krnm	1352	5	molecule	molecule	NN
cord-022353-q2k2krnm	1352	6	that	that	WDT
cord-022353-q2k2krnm	1352	7	freely	freely	RB
cord-022353-q2k2krnm	1352	8	diffuses	diffuse	VBZ
cord-022353-q2k2krnm	1352	9	across	across	IN
cord-022353-q2k2krnm	1352	10	cell	cell	NN
cord-022353-q2k2krnm	1352	11	membranes	membrane	NNS
cord-022353-q2k2krnm	1352	12	,	,	,
cord-022353-q2k2krnm	1352	13	and	and	CC
cord-022353-q2k2krnm	1352	14	therefore	therefore	RB
cord-022353-q2k2krnm	1352	15	the	the	DT
cord-022353-q2k2krnm	1352	16	urea	urea	NN
cord-022353-q2k2krnm	1352	17	concentration	concentration	NN
cord-022353-q2k2krnm	1352	18	is	be	VBZ
cord-022353-q2k2krnm	1352	19	the	the	DT
cord-022353-q2k2krnm	1352	20	same	same	JJ
cord-022353-q2k2krnm	1352	21	in	in	IN
cord-022353-q2k2krnm	1352	22	blood	blood	NN
cord-022353-q2k2krnm	1352	23	,	,	,
cord-022353-q2k2krnm	1352	24	serum	serum	NN
cord-022353-q2k2krnm	1352	25	,	,	,
cord-022353-q2k2krnm	1352	26	and	and	CC
cord-022353-q2k2krnm	1352	27	plasma	plasma	NN
cord-022353-q2k2krnm	1352	28	.	.	.
cord-022353-q2k2krnm	1353	1	Traditionally	traditionally	RB
cord-022353-q2k2krnm	1353	2	,	,	,
cord-022353-q2k2krnm	1353	3	urea	urea	NN
cord-022353-q2k2krnm	1353	4	concentrations	concentration	NNS
cord-022353-q2k2krnm	1353	5	is	be	VBZ
cord-022353-q2k2krnm	1353	6	measured	measure	VBN
cord-022353-q2k2krnm	1353	7	in	in	IN
cord-022353-q2k2krnm	1353	8	terms	term	NNS
cord-022353-q2k2krnm	1353	9	of	of	IN
cord-022353-q2k2krnm	1353	10	urea	urea	NN
cord-022353-q2k2krnm	1353	11	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1353	12	(	(	-LRB-
cord-022353-q2k2krnm	1353	13	the	the	DT
cord-022353-q2k2krnm	1353	14	amount	amount	NN
cord-022353-q2k2krnm	1353	15	of	of	IN
cord-022353-q2k2krnm	1353	16	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1353	17	contained	contain	VBN
cord-022353-q2k2krnm	1353	18	within	within	IN
cord-022353-q2k2krnm	1353	19	urea	urea	NN
cord-022353-q2k2krnm	1353	20	)	)	-RRB-
cord-022353-q2k2krnm	1353	21	.	.	.
cord-022353-q2k2krnm	1354	1	Determination	determination	NN
cord-022353-q2k2krnm	1354	2	of	of	IN
cord-022353-q2k2krnm	1354	3	urea	urea	NN
cord-022353-q2k2krnm	1354	4	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1354	5	is	be	VBZ
cord-022353-q2k2krnm	1354	6	usually	usually	RB
cord-022353-q2k2krnm	1354	7	made	make	VBN
cord-022353-q2k2krnm	1354	8	from	from	IN
cord-022353-q2k2krnm	1354	9	serum	serum	NN
cord-022353-q2k2krnm	1354	10	,	,	,
cord-022353-q2k2krnm	1354	11	but	but	CC
cord-022353-q2k2krnm	1354	12	whole	whole	JJ
cord-022353-q2k2krnm	1354	13	blood	blood	NN
cord-022353-q2k2krnm	1354	14	can	can	MD
cord-022353-q2k2krnm	1354	15	be	be	VB
cord-022353-q2k2krnm	1354	16	used	use	VBN
cord-022353-q2k2krnm	1354	17	(	(	-LRB-
cord-022353-q2k2krnm	1354	18	hence	hence	RB
cord-022353-q2k2krnm	1354	19	the	the	DT
cord-022353-q2k2krnm	1354	20	term	term	NN
cord-022353-q2k2krnm	1354	21	blood	blood	NN
cord-022353-q2k2krnm	1354	22	urea	urea	NN
cord-022353-q2k2krnm	1354	23	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1354	24	[	[	-LRB-
cord-022353-q2k2krnm	1354	25	BUN	bun	NN
cord-022353-q2k2krnm	1354	26	]	]	-RRB-
cord-022353-q2k2krnm	1354	27	)	)	-RRB-
cord-022353-q2k2krnm	1354	28	.	.	.
cord-022353-q2k2krnm	1355	1	Quantification	quantification	NN
cord-022353-q2k2krnm	1355	2	of	of	IN
cord-022353-q2k2krnm	1355	3	urea	urea	NN
cord-022353-q2k2krnm	1355	4	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1355	5	is	be	VBZ
cord-022353-q2k2krnm	1355	6	based	base	VBN
cord-022353-q2k2krnm	1355	7	on	on	IN
cord-022353-q2k2krnm	1355	8	spectrophotometry	spectrophotometry	NN
cord-022353-q2k2krnm	1355	9	assays	assay	NNS
cord-022353-q2k2krnm	1355	10	,	,	,
cord-022353-q2k2krnm	1355	11	measuring	measure	VBG
cord-022353-q2k2krnm	1355	12	the	the	DT
cord-022353-q2k2krnm	1355	13	amount	amount	NN
cord-022353-q2k2krnm	1355	14	of	of	IN
cord-022353-q2k2krnm	1355	15	urea	urea	NN
cord-022353-q2k2krnm	1355	16	that	that	WDT
cord-022353-q2k2krnm	1355	17	is	be	VBZ
cord-022353-q2k2krnm	1355	18	hydrolyzed	hydrolyze	VBN
cord-022353-q2k2krnm	1355	19	by	by	IN
cord-022353-q2k2krnm	1355	20	urease	urease	NN
cord-022353-q2k2krnm	1355	21	.	.	.
cord-022353-q2k2krnm	1356	1	Frith	Frith	NNP
cord-022353-q2k2krnm	1356	2	et	et	NNP
cord-022353-q2k2krnm	1356	3	al	al	NNP
cord-022353-q2k2krnm	1356	4	.	.	.
cord-022353-q2k2krnm	1357	1	(	(	-LRB-
cord-022353-q2k2krnm	1357	2	1980	1980	CD
cord-022353-q2k2krnm	1357	3	)	)	-RRB-
cord-022353-q2k2krnm	1357	4	investigated	investigate	VBN
cord-022353-q2k2krnm	1357	5	urea	urea	NN
cord-022353-q2k2krnm	1357	6	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1357	7	levels	level	NNS
cord-022353-q2k2krnm	1357	8	in	in	IN
cord-022353-q2k2krnm	1357	9	BALB	BALB	NNP
cord-022353-q2k2krnm	1357	10	/	/	SYM
cord-022353-q2k2krnm	1357	11	c	c	NN
cord-022353-q2k2krnm	1357	12	and	and	CC
cord-022353-q2k2krnm	1357	13	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1357	14	mice	mouse	NNS
cord-022353-q2k2krnm	1357	15	.	.	.
cord-022353-q2k2krnm	1358	1	Urea	urea	NN
cord-022353-q2k2krnm	1358	2	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1358	3	levels	level	NNS
cord-022353-q2k2krnm	1358	4	decreased	decrease	VBD
cord-022353-q2k2krnm	1358	5	after	after	IN
cord-022353-q2k2krnm	1358	6	3	3	CD
cord-022353-q2k2krnm	1358	7	months	month	NNS
cord-022353-q2k2krnm	1358	8	of	of	IN
cord-022353-q2k2krnm	1358	9	age	age	NN
cord-022353-q2k2krnm	1358	10	but	but	CC
cord-022353-q2k2krnm	1358	11	increased	increase	VBD
cord-022353-q2k2krnm	1358	12	again	again	RB
cord-022353-q2k2krnm	1358	13	after	after	IN
cord-022353-q2k2krnm	1358	14	12	12	CD
cord-022353-q2k2krnm	1358	15	months	month	NNS
cord-022353-q2k2krnm	1358	16	in	in	IN
cord-022353-q2k2krnm	1358	17	both	both	DT
cord-022353-q2k2krnm	1358	18	sexes	sex	NNS
cord-022353-q2k2krnm	1358	19	.	.	.
cord-022353-q2k2krnm	1359	1	In	in	IN
cord-022353-q2k2krnm	1359	2	BALB	BALB	NNP
cord-022353-q2k2krnm	1359	3	/	/	SYM
cord-022353-q2k2krnm	1359	4	c	c	NN
cord-022353-q2k2krnm	1359	5	mice	mouse	NNS
cord-022353-q2k2krnm	1359	6	,	,	,
cord-022353-q2k2krnm	1359	7	levels	level	NNS
cord-022353-q2k2krnm	1359	8	were	be	VBD
cord-022353-q2k2krnm	1359	9	higher	high	JJR
cord-022353-q2k2krnm	1359	10	in	in	IN
cord-022353-q2k2krnm	1359	11	males	male	NNS
cord-022353-q2k2krnm	1359	12	than	than	IN
cord-022353-q2k2krnm	1359	13	females	female	NNS
cord-022353-q2k2krnm	1359	14	,	,	,
cord-022353-q2k2krnm	1359	15	whereas	whereas	IN
cord-022353-q2k2krnm	1359	16	in	in	IN
cord-022353-q2k2krnm	1359	17	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1359	18	mice	mouse	NNS
cord-022353-q2k2krnm	1359	19	,	,	,
cord-022353-q2k2krnm	1359	20	females	female	NNS
cord-022353-q2k2krnm	1359	21	had	have	VBD
cord-022353-q2k2krnm	1359	22	significantly	significantly	RB
cord-022353-q2k2krnm	1359	23	higher	high	JJR
cord-022353-q2k2krnm	1359	24	levels	level	NNS
cord-022353-q2k2krnm	1359	25	than	than	IN
cord-022353-q2k2krnm	1359	26	males	male	NNS
cord-022353-q2k2krnm	1359	27	.	.	.
cord-022353-q2k2krnm	1360	1	Elevated	elevated	JJ
cord-022353-q2k2krnm	1360	2	urea	urea	NN
cord-022353-q2k2krnm	1360	3	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1360	4	(	(	-LRB-
cord-022353-q2k2krnm	1360	5	azotemia	azotemia	NN
cord-022353-q2k2krnm	1360	6	)	)	-RRB-
cord-022353-q2k2krnm	1360	7	can	can	MD
cord-022353-q2k2krnm	1360	8	be	be	VB
cord-022353-q2k2krnm	1360	9	caused	cause	VBN
cord-022353-q2k2krnm	1360	10	by	by	IN
cord-022353-q2k2krnm	1360	11	prerenal	prerenal	NNP
cord-022353-q2k2krnm	1360	12	,	,	,
cord-022353-q2k2krnm	1360	13	renal	renal	JJ
cord-022353-q2k2krnm	1360	14	,	,	,
cord-022353-q2k2krnm	1360	15	and	and	CC
cord-022353-q2k2krnm	1360	16	postrenal	postrenal	JJ
cord-022353-q2k2krnm	1360	17	conditions	condition	NNS
cord-022353-q2k2krnm	1360	18	.	.	.
cord-022353-q2k2krnm	1361	1	Prerenal	Prerenal	NNP
cord-022353-q2k2krnm	1361	2	causes	cause	NNS
cord-022353-q2k2krnm	1361	3	include	include	VBP
cord-022353-q2k2krnm	1361	4	increased	increase	VBN
cord-022353-q2k2krnm	1361	5	protein	protein	NN
cord-022353-q2k2krnm	1361	6	catabolism	catabolism	NN
cord-022353-q2k2krnm	1361	7	(	(	-LRB-
cord-022353-q2k2krnm	1361	8	such	such	JJ
cord-022353-q2k2krnm	1361	9	as	as	IN
cord-022353-q2k2krnm	1361	10	with	with	IN
cord-022353-q2k2krnm	1361	11	inflammation	inflammation	NN
cord-022353-q2k2krnm	1361	12	,	,	,
cord-022353-q2k2krnm	1361	13	starvation	starvation	NN
cord-022353-q2k2krnm	1361	14	,	,	,
cord-022353-q2k2krnm	1361	15	and	and	CC
cord-022353-q2k2krnm	1361	16	high	high	JJ
cord-022353-q2k2krnm	1361	17	-	-	HYPH
cord-022353-q2k2krnm	1361	18	protein	protein	NN
cord-022353-q2k2krnm	1361	19	diets	diet	NNS
cord-022353-q2k2krnm	1361	20	)	)	-RRB-
cord-022353-q2k2krnm	1361	21	.	.	.
cord-022353-q2k2krnm	1362	1	Renal	renal	JJ
cord-022353-q2k2krnm	1362	2	causes	cause	NNS
cord-022353-q2k2krnm	1362	3	usually	usually	RB
cord-022353-q2k2krnm	1362	4	are	be	VBP
cord-022353-q2k2krnm	1362	5	associated	associate	VBN
cord-022353-q2k2krnm	1362	6	with	with	IN
cord-022353-q2k2krnm	1362	7	conditions	condition	NNS
cord-022353-q2k2krnm	1362	8	that	that	WDT
cord-022353-q2k2krnm	1362	9	compromise	compromise	VBP
cord-022353-q2k2krnm	1362	10	more	more	JJR
cord-022353-q2k2krnm	1362	11	than	than	IN
cord-022353-q2k2krnm	1362	12	70	70	CD
cord-022353-q2k2krnm	1362	13	-	-	SYM
cord-022353-q2k2krnm	1362	14	75	75	CD
cord-022353-q2k2krnm	1362	15	%	%	NN
cord-022353-q2k2krnm	1362	16	of	of	IN
cord-022353-q2k2krnm	1362	17	functional	functional	JJ
cord-022353-q2k2krnm	1362	18	renal	renal	JJ
cord-022353-q2k2krnm	1362	19	mass	mass	NN
cord-022353-q2k2krnm	1362	20	and	and	CC
cord-022353-q2k2krnm	1362	21	include	include	VBP
cord-022353-q2k2krnm	1362	22	conditions	condition	NNS
cord-022353-q2k2krnm	1362	23	such	such	JJ
cord-022353-q2k2krnm	1362	24	as	as	IN
cord-022353-q2k2krnm	1362	25	renal	renal	JJ
cord-022353-q2k2krnm	1362	26	amyloidosis	amyloidosis	NN
cord-022353-q2k2krnm	1362	27	,	,	,
cord-022353-q2k2krnm	1362	28	glomerular	glomerular	JJ
cord-022353-q2k2krnm	1362	29	immune	immune	JJ
cord-022353-q2k2krnm	1362	30	complex	complex	JJ
cord-022353-q2k2krnm	1362	31	disease	disease	NN
cord-022353-q2k2krnm	1362	32	,	,	,
cord-022353-q2k2krnm	1362	33	and	and	CC
cord-022353-q2k2krnm	1362	34	polycystic	polycystic	JJ
cord-022353-q2k2krnm	1362	35	disease	disease	NN
cord-022353-q2k2krnm	1362	36	.	.	.
cord-022353-q2k2krnm	1363	1	Postrenal	Postrenal	NNP
cord-022353-q2k2krnm	1363	2	include	include	VBP
cord-022353-q2k2krnm	1363	3	any	any	DT
cord-022353-q2k2krnm	1363	4	cause	cause	NN
cord-022353-q2k2krnm	1363	5	that	that	IN
cord-022353-q2k2krnm	1363	6	results	result	NNS
cord-022353-q2k2krnm	1363	7	in	in	IN
cord-022353-q2k2krnm	1363	8	obstruction	obstruction	NN
cord-022353-q2k2krnm	1363	9	of	of	IN
cord-022353-q2k2krnm	1363	10	the	the	DT
cord-022353-q2k2krnm	1363	11	lower	low	JJR
cord-022353-q2k2krnm	1363	12	urinary	urinary	JJ
cord-022353-q2k2krnm	1363	13	system	system	NN
cord-022353-q2k2krnm	1363	14	.	.	.
cord-022353-q2k2krnm	1364	1	Decreased	decrease	VBN
cord-022353-q2k2krnm	1364	2	urea	urea	NN
cord-022353-q2k2krnm	1364	3	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1364	4	is	be	VBZ
cord-022353-q2k2krnm	1364	5	found	find	VBN
cord-022353-q2k2krnm	1364	6	with	with	IN
cord-022353-q2k2krnm	1364	7	disease	disease	NN
cord-022353-q2k2krnm	1364	8	associated	associate	VBN
cord-022353-q2k2krnm	1364	9	with	with	IN
cord-022353-q2k2krnm	1364	10	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1364	11	insufficiency	insufficiency	NN
cord-022353-q2k2krnm	1364	12	and	and	CC
cord-022353-q2k2krnm	1364	13	low	low	JJ
cord-022353-q2k2krnm	1364	14	-	-	HYPH
cord-022353-q2k2krnm	1364	15	protein	protein	NN
cord-022353-q2k2krnm	1364	16	diets	diet	NNS
cord-022353-q2k2krnm	1364	17	.	.	.
cord-022353-q2k2krnm	1365	1	Creatinine	creatinine	NN
cord-022353-q2k2krnm	1365	2	is	be	VBZ
cord-022353-q2k2krnm	1365	3	a	a	DT
cord-022353-q2k2krnm	1365	4	degradation	degradation	NN
cord-022353-q2k2krnm	1365	5	product	product	NN
cord-022353-q2k2krnm	1365	6	of	of	IN
cord-022353-q2k2krnm	1365	7	creatine	creatine	NN
cord-022353-q2k2krnm	1365	8	and	and	CC
cord-022353-q2k2krnm	1365	9	creatine	creatine	NN
cord-022353-q2k2krnm	1365	10	phosphate	phosphate	NN
cord-022353-q2k2krnm	1365	11	and	and	CC
cord-022353-q2k2krnm	1365	12	represents	represent	VBZ
cord-022353-q2k2krnm	1365	13	an	an	DT
cord-022353-q2k2krnm	1365	14	end	end	NN
cord-022353-q2k2krnm	1365	15	-	-	HYPH
cord-022353-q2k2krnm	1365	16	product	product	NN
cord-022353-q2k2krnm	1365	17	of	of	IN
cord-022353-q2k2krnm	1365	18	muscle	muscle	NN
cord-022353-q2k2krnm	1365	19	metabolism	metabolism	NN
cord-022353-q2k2krnm	1365	20	.	.	.
cord-022353-q2k2krnm	1366	1	Quantification	quantification	NN
cord-022353-q2k2krnm	1366	2	of	of	IN
cord-022353-q2k2krnm	1366	3	creatinine	creatinine	NN
cord-022353-q2k2krnm	1366	4	is	be	VBZ
cord-022353-q2k2krnm	1366	5	based	base	VBN
cord-022353-q2k2krnm	1366	6	on	on	IN
cord-022353-q2k2krnm	1366	7	spectrophotometry	spectrophotometry	NN
cord-022353-q2k2krnm	1366	8	assays	assay	NNS
cord-022353-q2k2krnm	1366	9	.	.	.
cord-022353-q2k2krnm	1367	1	Baseline	baseline	JJ
cord-022353-q2k2krnm	1367	2	serum	serum	NN
cord-022353-q2k2krnm	1367	3	levels	level	NNS
cord-022353-q2k2krnm	1367	4	are	be	VBP
cord-022353-q2k2krnm	1367	5	directly	directly	RB
cord-022353-q2k2krnm	1367	6	related	relate	VBN
cord-022353-q2k2krnm	1367	7	to	to	IN
cord-022353-q2k2krnm	1367	8	muscular	muscular	JJ
cord-022353-q2k2krnm	1367	9	conditioning	conditioning	NN
cord-022353-q2k2krnm	1367	10	and	and	CC
cord-022353-q2k2krnm	1367	11	total	total	JJ
cord-022353-q2k2krnm	1367	12	muscular	muscular	JJ
cord-022353-q2k2krnm	1367	13	mass	mass	NN
cord-022353-q2k2krnm	1367	14	,	,	,
cord-022353-q2k2krnm	1367	15	which	which	WDT
cord-022353-q2k2krnm	1367	16	varies	vary	VBZ
cord-022353-q2k2krnm	1367	17	between	between	IN
cord-022353-q2k2krnm	1367	18	individuals	individual	NNS
cord-022353-q2k2krnm	1367	19	.	.	.
cord-022353-q2k2krnm	1368	1	Pathologically	pathologically	RB
cord-022353-q2k2krnm	1368	2	elevated	elevated	JJ
cord-022353-q2k2krnm	1368	3	serum	serum	NN
cord-022353-q2k2krnm	1368	4	creatinine	creatinine	NN
cord-022353-q2k2krnm	1368	5	levels	level	NNS
cord-022353-q2k2krnm	1368	6	are	be	VBP
cord-022353-q2k2krnm	1368	7	caused	cause	VBN
cord-022353-q2k2krnm	1368	8	by	by	IN
cord-022353-q2k2krnm	1368	9	the	the	DT
cord-022353-q2k2krnm	1368	10	same	same	JJ
cord-022353-q2k2krnm	1368	11	prerenal	prerenal	NN
cord-022353-q2k2krnm	1368	12	,	,	,
cord-022353-q2k2krnm	1368	13	renal	renal	JJ
cord-022353-q2k2krnm	1368	14	,	,	,
cord-022353-q2k2krnm	1368	15	and	and	CC
cord-022353-q2k2krnm	1368	16	postrenal	postrenal	JJ
cord-022353-q2k2krnm	1368	17	causes	cause	NNS
cord-022353-q2k2krnm	1368	18	that	that	WDT
cord-022353-q2k2krnm	1368	19	elevate	elevate	VBP
cord-022353-q2k2krnm	1368	20	urea	urea	NN
cord-022353-q2k2krnm	1368	21	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1368	22	in	in	IN
cord-022353-q2k2krnm	1368	23	serum	serum	NN
cord-022353-q2k2krnm	1368	24	.	.	.
cord-022353-q2k2krnm	1369	1	Therefore	therefore	RB
cord-022353-q2k2krnm	1369	2	,	,	,
cord-022353-q2k2krnm	1369	3	quantification	quantification	NN
cord-022353-q2k2krnm	1369	4	of	of	IN
cord-022353-q2k2krnm	1369	5	serum	serum	NN
cord-022353-q2k2krnm	1369	6	creatinine	creatinine	NN
cord-022353-q2k2krnm	1369	7	offers	offer	VBZ
cord-022353-q2k2krnm	1369	8	no	no	DT
cord-022353-q2k2krnm	1369	9	interpretative	interpretative	JJ
cord-022353-q2k2krnm	1369	10	advantage	advantage	NN
cord-022353-q2k2krnm	1369	11	over	over	IN
cord-022353-q2k2krnm	1369	12	urea	urea	NN
cord-022353-q2k2krnm	1369	13	nitrogen	nitrogen	NN
cord-022353-q2k2krnm	1369	14	(	(	-LRB-
cord-022353-q2k2krnm	1369	15	Everett	Everett	NNP
cord-022353-q2k2krnm	1369	16	and	and	CC
cord-022353-q2k2krnm	1369	17	Harrison	Harrison	NNP
cord-022353-q2k2krnm	1369	18	1983	1983	CD
cord-022353-q2k2krnm	1369	19	)	)	-RRB-
cord-022353-q2k2krnm	1369	20	.	.	.
cord-022353-q2k2krnm	1370	1	Proteinuria	Proteinuria	NNP
cord-022353-q2k2krnm	1370	2	is	be	VBZ
cord-022353-q2k2krnm	1370	3	a	a	DT
cord-022353-q2k2krnm	1370	4	common	common	JJ
cord-022353-q2k2krnm	1370	5	finding	finding	NN
cord-022353-q2k2krnm	1370	6	in	in	IN
cord-022353-q2k2krnm	1370	7	normal	normal	JJ
cord-022353-q2k2krnm	1370	8	mice	mouse	NNS
cord-022353-q2k2krnm	1370	9	,	,	,
cord-022353-q2k2krnm	1370	10	and	and	CC
cord-022353-q2k2krnm	1370	11	includes	include	VBZ
cord-022353-q2k2krnm	1370	12	rodent	rodent	NN
cord-022353-q2k2krnm	1370	13	-	-	HYPH
cord-022353-q2k2krnm	1370	14	specific	specific	JJ
cord-022353-q2k2krnm	1370	15	proteins	protein	NNS
cord-022353-q2k2krnm	1370	16	such	such	JJ
cord-022353-q2k2krnm	1370	17	as	as	IN
cord-022353-q2k2krnm	1370	18	uromucoid	uromucoid	JJ
cord-022353-q2k2krnm	1370	19	,	,	,
cord-022353-q2k2krnm	1370	20	small	small	JJ
cord-022353-q2k2krnm	1370	21	quantities	quantity	NNS
cord-022353-q2k2krnm	1370	22	of	of	IN
cord-022353-q2k2krnm	1370	23	c~-and	c~-and	NNP
cord-022353-q2k2krnm	1370	24	[	[	-LRB-
cord-022353-q2k2krnm	1370	25	3-globulins	3-globulins	CD
cord-022353-q2k2krnm	1370	26	,	,	,
cord-022353-q2k2krnm	1370	27	and	and	CC
cord-022353-q2k2krnm	1370	28	a	a	DT
cord-022353-q2k2krnm	1370	29	family	family	NN
cord-022353-q2k2krnm	1370	30	of	of	IN
cord-022353-q2k2krnm	1370	31	prealbumins	prealbumin	NNS
cord-022353-q2k2krnm	1370	32	known	know	VBN
cord-022353-q2k2krnm	1370	33	as	as	IN
cord-022353-q2k2krnm	1370	34	major	major	JJ
cord-022353-q2k2krnm	1370	35	urinary	urinary	JJ
cord-022353-q2k2krnm	1370	36	protein	protein	NN
cord-022353-q2k2krnm	1370	37	(	(	-LRB-
cord-022353-q2k2krnm	1370	38	MUP	MUP	NNP
cord-022353-q2k2krnm	1370	39	)	)	-RRB-
cord-022353-q2k2krnm	1370	40	.	.	.
cord-022353-q2k2krnm	1371	1	The	the	DT
cord-022353-q2k2krnm	1371	2	MUP	MUP	NNP
cord-022353-q2k2krnm	1371	3	has	have	VBZ
cord-022353-q2k2krnm	1371	4	three	three	CD
cord-022353-q2k2krnm	1371	5	electrophoretic	electrophoretic	JJ
cord-022353-q2k2krnm	1371	6	variants	variant	NNS
cord-022353-q2k2krnm	1371	7	,	,	,
cord-022353-q2k2krnm	1371	8	designated	designate	VBN
cord-022353-q2k2krnm	1371	9	as	as	IN
cord-022353-q2k2krnm	1371	10	MUP-1	MUP-1	NNP
cord-022353-q2k2krnm	1371	11	,	,	,
cord-022353-q2k2krnm	1371	12	MUP-2	MUP-2	NNP
cord-022353-q2k2krnm	1371	13	,	,	,
cord-022353-q2k2krnm	1371	14	and	and	CC
cord-022353-q2k2krnm	1371	15	MUP-3	MUP-3	NNP
cord-022353-q2k2krnm	1371	16	,	,	,
cord-022353-q2k2krnm	1371	17	that	that	WDT
cord-022353-q2k2krnm	1371	18	are	be	VBP
cord-022353-q2k2krnm	1371	19	under	under	IN
cord-022353-q2k2krnm	1371	20	both	both	CC
cord-022353-q2k2krnm	1371	21	genetic	genetic	JJ
cord-022353-q2k2krnm	1371	22	and	and	CC
cord-022353-q2k2krnm	1371	23	hormonal	hormonal	JJ
cord-022353-q2k2krnm	1371	24	control	control	NN
cord-022353-q2k2krnm	1371	25	.	.	.
cord-022353-q2k2krnm	1372	1	A	a	DT
cord-022353-q2k2krnm	1372	2	regulatory	regulatory	JJ
cord-022353-q2k2krnm	1372	3	locus	locus	NN
cord-022353-q2k2krnm	1372	4	designated	designate	VBN
cord-022353-q2k2krnm	1372	5	Mup-1	Mup-1	NNP
cord-022353-q2k2krnm	1372	6	with	with	IN
cord-022353-q2k2krnm	1372	7	codominantly	codominantly	RB
cord-022353-q2k2krnm	1372	8	expressed	express	VBN
cord-022353-q2k2krnm	1372	9	alleles	allele	NNS
cord-022353-q2k2krnm	1372	10	a	a	DT
cord-022353-q2k2krnm	1372	11	and	and	CC
cord-022353-q2k2krnm	1372	12	b	b	LS
cord-022353-q2k2krnm	1372	13	(	(	-LRB-
cord-022353-q2k2krnm	1372	14	located	locate	VBN
cord-022353-q2k2krnm	1372	15	on	on	IN
cord-022353-q2k2krnm	1372	16	chromosome	chromosome	NN
cord-022353-q2k2krnm	1372	17	4	4	CD
cord-022353-q2k2krnm	1372	18	)	)	-RRB-
cord-022353-q2k2krnm	1372	19	controls	control	VBZ
cord-022353-q2k2krnm	1372	20	the	the	DT
cord-022353-q2k2krnm	1372	21	urinary	urinary	JJ
cord-022353-q2k2krnm	1372	22	levels	level	NNS
cord-022353-q2k2krnm	1372	23	of	of	IN
cord-022353-q2k2krnm	1372	24	the	the	DT
cord-022353-q2k2krnm	1372	25	three	three	CD
cord-022353-q2k2krnm	1372	26	variants	variant	NNS
cord-022353-q2k2krnm	1372	27	.	.	.
cord-022353-q2k2krnm	1373	1	The	the	DT
cord-022353-q2k2krnm	1373	2	MUP	MUP	NNP
cord-022353-q2k2krnm	1373	3	is	be	VBZ
cord-022353-q2k2krnm	1373	4	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1373	5	in	in	IN
cord-022353-q2k2krnm	1373	6	the	the	DT
cord-022353-q2k2krnm	1373	7	liver	liver	NN
cord-022353-q2k2krnm	1373	8	,	,	,
cord-022353-q2k2krnm	1373	9	secreted	secrete	VBN
cord-022353-q2k2krnm	1373	10	into	into	IN
cord-022353-q2k2krnm	1373	11	blood	blood	NN
cord-022353-q2k2krnm	1373	12	,	,	,
cord-022353-q2k2krnm	1373	13	and	and	CC
cord-022353-q2k2krnm	1373	14	excreted	excrete	VBN
cord-022353-q2k2krnm	1373	15	into	into	IN
cord-022353-q2k2krnm	1373	16	urine	urine	NN
cord-022353-q2k2krnm	1373	17	.	.	.
cord-022353-q2k2krnm	1374	1	Males	male	NNS
cord-022353-q2k2krnm	1374	2	are	be	VBP
cord-022353-q2k2krnm	1374	3	have	have	VBP
cord-022353-q2k2krnm	1374	4	higher	high	JJR
cord-022353-q2k2krnm	1374	5	levels	level	NNS
cord-022353-q2k2krnm	1374	6	of	of	IN
cord-022353-q2k2krnm	1374	7	proteinuria	proteinuria	NN
cord-022353-q2k2krnm	1374	8	than	than	IN
cord-022353-q2k2krnm	1374	9	are	be	VBP
cord-022353-q2k2krnm	1374	10	females	female	NNS
cord-022353-q2k2krnm	1374	11	,	,	,
cord-022353-q2k2krnm	1374	12	with	with	IN
cord-022353-q2k2krnm	1374	13	levels	level	NNS
cord-022353-q2k2krnm	1374	14	of	of	IN
cord-022353-q2k2krnm	1374	15	5	5	CD
cord-022353-q2k2krnm	1374	16	mg	mg	NNP
cord-022353-q2k2krnm	1374	17	/	/	SYM
cord-022353-q2k2krnm	1374	18	ml	ml	NN
cord-022353-q2k2krnm	1374	19	,	,	,
cord-022353-q2k2krnm	1374	20	and	and	CC
cord-022353-q2k2krnm	1374	21	age	age	NN
cord-022353-q2k2krnm	1374	22	-	-	HYPH
cord-022353-q2k2krnm	1374	23	related	relate	VBN
cord-022353-q2k2krnm	1374	24	increases	increase	NNS
cord-022353-q2k2krnm	1374	25	are	be	VBP
cord-022353-q2k2krnm	1374	26	seen	see	VBN
cord-022353-q2k2krnm	1374	27	in	in	IN
cord-022353-q2k2krnm	1374	28	mice	mouse	NNS
cord-022353-q2k2krnm	1374	29	of	of	IN
cord-022353-q2k2krnm	1374	30	both	both	DT
cord-022353-q2k2krnm	1374	31	sexes	sex	NNS
cord-022353-q2k2krnm	1374	32	.	.	.
cord-022353-q2k2krnm	1375	1	Increases	increase	NNS
cord-022353-q2k2krnm	1375	2	in	in	IN
cord-022353-q2k2krnm	1375	3	other	other	JJ
cord-022353-q2k2krnm	1375	4	urinary	urinary	JJ
cord-022353-q2k2krnm	1375	5	proteins	protein	NNS
cord-022353-q2k2krnm	1375	6	have	have	VBP
cord-022353-q2k2krnm	1375	7	been	be	VBN
cord-022353-q2k2krnm	1375	8	associated	associate	VBN
cord-022353-q2k2krnm	1375	9	with	with	IN
cord-022353-q2k2krnm	1375	10	a	a	DT
cord-022353-q2k2krnm	1375	11	variety	variety	NN
cord-022353-q2k2krnm	1375	12	of	of	IN
cord-022353-q2k2krnm	1375	13	renal	renal	JJ
cord-022353-q2k2krnm	1375	14	diseases	disease	NNS
cord-022353-q2k2krnm	1375	15	in	in	IN
cord-022353-q2k2krnm	1375	16	mice	mouse	NNS
cord-022353-q2k2krnm	1375	17	.	.	.
cord-022353-q2k2krnm	1376	1	The	the	DT
cord-022353-q2k2krnm	1376	2	concentration	concentration	NN
cord-022353-q2k2krnm	1376	3	of	of	IN
cord-022353-q2k2krnm	1376	4	urine	urine	NN
cord-022353-q2k2krnm	1376	5	(	(	-LRB-
cord-022353-q2k2krnm	1376	6	amount	amount	NN
cord-022353-q2k2krnm	1376	7	of	of	IN
cord-022353-q2k2krnm	1376	8	solutes	solute	NNS
cord-022353-q2k2krnm	1376	9	dissolved	dissolve	VBN
cord-022353-q2k2krnm	1376	10	in	in	IN
cord-022353-q2k2krnm	1376	11	urine	urine	NN
cord-022353-q2k2krnm	1376	12	)	)	-RRB-
cord-022353-q2k2krnm	1376	13	can	can	MD
cord-022353-q2k2krnm	1376	14	be	be	VB
cord-022353-q2k2krnm	1376	15	measured	measure	VBN
cord-022353-q2k2krnm	1376	16	by	by	IN
cord-022353-q2k2krnm	1376	17	urine	urine	NN
cord-022353-q2k2krnm	1376	18	specific	specific	JJ
cord-022353-q2k2krnm	1376	19	gravity	gravity	NN
cord-022353-q2k2krnm	1376	20	(	(	-LRB-
cord-022353-q2k2krnm	1376	21	USG	USG	NNP
cord-022353-q2k2krnm	1376	22	)	)	-RRB-
cord-022353-q2k2krnm	1376	23	or	or	CC
cord-022353-q2k2krnm	1376	24	osmolality	osmolality	NN
cord-022353-q2k2krnm	1376	25	.	.	.
cord-022353-q2k2krnm	1377	1	Urine	urine	NN
cord-022353-q2k2krnm	1377	2	concentration	concentration	NN
cord-022353-q2k2krnm	1377	3	in	in	IN
cord-022353-q2k2krnm	1377	4	healthy	healthy	JJ
cord-022353-q2k2krnm	1377	5	mice	mouse	NNS
cord-022353-q2k2krnm	1377	6	is	be	VBZ
cord-022353-q2k2krnm	1377	7	very	very	RB
cord-022353-q2k2krnm	1377	8	high	high	JJ
cord-022353-q2k2krnm	1377	9	.	.	.
cord-022353-q2k2krnm	1378	1	Watts	Watts	NNP
cord-022353-q2k2krnm	1378	2	(	(	-LRB-
cord-022353-q2k2krnm	1378	3	1975	1975	CD
cord-022353-q2k2krnm	1378	4	)	)	-RRB-
cord-022353-q2k2krnm	1378	5	determined	determine	VBD
cord-022353-q2k2krnm	1378	6	the	the	DT
cord-022353-q2k2krnm	1378	7	USG	USG	NNP
cord-022353-q2k2krnm	1378	8	of	of	IN
cord-022353-q2k2krnm	1378	9	healthy	healthy	JJ
cord-022353-q2k2krnm	1378	10	CBA	CBA	NNP
cord-022353-q2k2krnm	1378	11	mice	mouse	NNS
cord-022353-q2k2krnm	1378	12	,	,	,
cord-022353-q2k2krnm	1378	13	which	which	WDT
cord-022353-q2k2krnm	1378	14	ranged	range	VBD
cord-022353-q2k2krnm	1378	15	from	from	IN
cord-022353-q2k2krnm	1378	16	1.060	1.060	CD
cord-022353-q2k2krnm	1378	17	to	to	IN
cord-022353-q2k2krnm	1378	18	1.080	1.080	CD
cord-022353-q2k2krnm	1378	19	.	.	.
cord-022353-q2k2krnm	1379	1	The	the	DT
cord-022353-q2k2krnm	1379	2	author	author	NN
cord-022353-q2k2krnm	1379	3	also	also	RB
cord-022353-q2k2krnm	1379	4	found	find	VBD
cord-022353-q2k2krnm	1379	5	the	the	DT
cord-022353-q2k2krnm	1379	6	USG	USG	NNP
cord-022353-q2k2krnm	1379	7	increased	increase	VBD
cord-022353-q2k2krnm	1379	8	from	from	IN
cord-022353-q2k2krnm	1379	9	20	20	CD
cord-022353-q2k2krnm	1379	10	to	to	TO
cord-022353-q2k2krnm	1379	11	80	80	CD
cord-022353-q2k2krnm	1379	12	days	day	NNS
cord-022353-q2k2krnm	1379	13	of	of	IN
cord-022353-q2k2krnm	1379	14	age	age	NN
cord-022353-q2k2krnm	1379	15	.	.	.
cord-022353-q2k2krnm	1380	1	The	the	DT
cord-022353-q2k2krnm	1380	2	urine	urine	NN
cord-022353-q2k2krnm	1380	3	concentrating	concentrate	VBG
cord-022353-q2k2krnm	1380	4	ability	ability	NN
cord-022353-q2k2krnm	1380	5	of	of	IN
cord-022353-q2k2krnm	1380	6	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1380	7	mice	mouse	NNS
cord-022353-q2k2krnm	1380	8	expressing	express	VBG
cord-022353-q2k2krnm	1380	9	human	human	JJ
cord-022353-q2k2krnm	1380	10	sickle	sickle	NN
cord-022353-q2k2krnm	1380	11	cell	cell	NN
cord-022353-q2k2krnm	1380	12	hemoglobin	hemoglobin	NN
cord-022353-q2k2krnm	1380	13	(	(	-LRB-
cord-022353-q2k2krnm	1380	14	KOs	KOs	NNP
cord-022353-q2k2krnm	1380	15	for	for	IN
cord-022353-q2k2krnm	1380	16	mouse	mouse	NN
cord-022353-q2k2krnm	1380	17	Hb	Hb	NNP
cord-022353-q2k2krnm	1380	18	)	)	-RRB-
cord-022353-q2k2krnm	1380	19	was	be	VBD
cord-022353-q2k2krnm	1380	20	assessed	assess	VBN
cord-022353-q2k2krnm	1380	21	by	by	IN
cord-022353-q2k2krnm	1380	22	Ryan	Ryan	NNP
cord-022353-q2k2krnm	1380	23	et	et	NNP
cord-022353-q2k2krnm	1380	24	al	al	NNP
cord-022353-q2k2krnm	1380	25	.	.	.
cord-022353-q2k2krnm	1381	1	(	(	-LRB-
cord-022353-q2k2krnm	1381	2	1997	1997	CD
cord-022353-q2k2krnm	1381	3	)	)	-RRB-
cord-022353-q2k2krnm	1381	4	.	.	.
cord-022353-q2k2krnm	1382	1	They	-PRON-	PRP
cord-022353-q2k2krnm	1382	2	found	find	VBD
cord-022353-q2k2krnm	1382	3	that	that	IN
cord-022353-q2k2krnm	1382	4	sickled	sickled	JJ
cord-022353-q2k2krnm	1382	5	cells	cell	NNS
cord-022353-q2k2krnm	1382	6	caused	cause	VBD
cord-022353-q2k2krnm	1382	7	vascular	vascular	JJ
cord-022353-q2k2krnm	1382	8	,	,	,
cord-022353-q2k2krnm	1382	9	tubular	tubular	JJ
cord-022353-q2k2krnm	1382	10	,	,	,
cord-022353-q2k2krnm	1382	11	and	and	CC
cord-022353-q2k2krnm	1382	12	glomerular	glomerular	JJ
cord-022353-q2k2krnm	1382	13	changes	change	NNS
cord-022353-q2k2krnm	1382	14	,	,	,
cord-022353-q2k2krnm	1382	15	as	as	RB
cord-022353-q2k2krnm	1382	16	well	well	RB
cord-022353-q2k2krnm	1382	17	as	as	IN
cord-022353-q2k2krnm	1382	18	corresponding	correspond	VBG
cord-022353-q2k2krnm	1382	19	hyposthenuria	hyposthenuria	NNP
cord-022353-q2k2krnm	1382	20	(	(	-LRB-
cord-022353-q2k2krnm	1382	21	4-h	4-h	CD
cord-022353-q2k2krnm	1382	22	water	water	NN
cord-022353-q2k2krnm	1382	23	deprived	deprive	VBD
cord-022353-q2k2krnm	1382	24	osmolality	osmolality	NN
cord-022353-q2k2krnm	1382	25	of	of	IN
cord-022353-q2k2krnm	1382	26	affected	affect	VBN
cord-022353-q2k2krnm	1382	27	mice	mouse	NNS
cord-022353-q2k2krnm	1382	28	was	be	VBD
cord-022353-q2k2krnm	1382	29	807	807	CD
cord-022353-q2k2krnm	1382	30	+	+	SYM
cord-022353-q2k2krnm	1382	31	285	285	CD
cord-022353-q2k2krnm	1382	32	mOsm	mOsm	NNS
cord-022353-q2k2krnm	1382	33	compared	compare	VBD
cord-022353-q2k2krnm	1382	34	to	to	IN
cord-022353-q2k2krnm	1382	35	1541	1541	CD
cord-022353-q2k2krnm	1382	36	+	+	SYM
cord-022353-q2k2krnm	1382	37	360	360	CD
cord-022353-q2k2krnm	1382	38	mOsm	mOsm	NNP
cord-022353-q2k2krnm	1382	39	in	in	IN
cord-022353-q2k2krnm	1382	40	controls	control	NNS
cord-022353-q2k2krnm	1382	41	)	)	-RRB-
cord-022353-q2k2krnm	1382	42	.	.	.
cord-022353-q2k2krnm	1383	1	I.	I.	NNP
cord-022353-q2k2krnm	1383	2	Electrolytes	Electrolytes	NNP
cord-022353-q2k2krnm	1383	3	1	1	CD
cord-022353-q2k2krnm	1383	4	.	.	.
cord-022353-q2k2krnm	1384	1	Sodium	sodium	NN
cord-022353-q2k2krnm	1384	2	,	,	,
cord-022353-q2k2krnm	1384	3	Potassium	Potassium	NNP
cord-022353-q2k2krnm	1384	4	,	,	,
cord-022353-q2k2krnm	1384	5	Chloride	Chloride	NNP
cord-022353-q2k2krnm	1384	6	,	,	,
cord-022353-q2k2krnm	1384	7	and	and	CC
cord-022353-q2k2krnm	1384	8	Phosphorus	Phosphorus	NNP
cord-022353-q2k2krnm	1384	9	Sodium	Sodium	NNP
cord-022353-q2k2krnm	1384	10	and	and	CC
cord-022353-q2k2krnm	1384	11	potassium	potassium	NN
cord-022353-q2k2krnm	1384	12	levels	level	NNS
cord-022353-q2k2krnm	1384	13	are	be	VBP
cord-022353-q2k2krnm	1384	14	easily	easily	RB
cord-022353-q2k2krnm	1384	15	measured	measure	VBN
cord-022353-q2k2krnm	1384	16	in	in	IN
cord-022353-q2k2krnm	1384	17	murine	murine	JJ
cord-022353-q2k2krnm	1384	18	serum	serum	NN
cord-022353-q2k2krnm	1384	19	using	use	VBG
cord-022353-q2k2krnm	1384	20	flame	flame	NN
cord-022353-q2k2krnm	1384	21	photometry	photometry	NN
cord-022353-q2k2krnm	1384	22	(	(	-LRB-
cord-022353-q2k2krnm	1384	23	lithium	lithium	NN
cord-022353-q2k2krnm	1384	24	reference	reference	NN
cord-022353-q2k2krnm	1384	25	)	)	-RRB-
cord-022353-q2k2krnm	1384	26	or	or	CC
cord-022353-q2k2krnm	1384	27	ion	ion	NN
cord-022353-q2k2krnm	1384	28	-	-	HYPH
cord-022353-q2k2krnm	1384	29	specific	specific	JJ
cord-022353-q2k2krnm	1384	30	electrodes	electrode	NNS
cord-022353-q2k2krnm	1384	31	.	.	.
cord-022353-q2k2krnm	1385	1	Serum	serum	NN
cord-022353-q2k2krnm	1385	2	sodium	sodium	NN
cord-022353-q2k2krnm	1385	3	levels	level	NNS
cord-022353-q2k2krnm	1385	4	are	be	VBP
cord-022353-q2k2krnm	1385	5	slightly	slightly	RB
cord-022353-q2k2krnm	1385	6	higher	high	JJR
cord-022353-q2k2krnm	1385	7	in	in	IN
cord-022353-q2k2krnm	1385	8	mice	mouse	NNS
cord-022353-q2k2krnm	1385	9	than	than	IN
cord-022353-q2k2krnm	1385	10	in	in	IN
cord-022353-q2k2krnm	1385	11	most	most	JJS
cord-022353-q2k2krnm	1385	12	other	other	JJ
cord-022353-q2k2krnm	1385	13	mammalian	mammalian	JJ
cord-022353-q2k2krnm	1385	14	species	specie	NNS
cord-022353-q2k2krnm	1385	15	,	,	,
cord-022353-q2k2krnm	1385	16	with	with	IN
cord-022353-q2k2krnm	1385	17	reported	report	VBN
cord-022353-q2k2krnm	1385	18	values	value	NNS
cord-022353-q2k2krnm	1385	19	of	of	IN
cord-022353-q2k2krnm	1385	20	174	174	CD
cord-022353-q2k2krnm	1385	21	+	+	SYM
cord-022353-q2k2krnm	1385	22	23	23	CD
cord-022353-q2k2krnm	1385	23	(	(	-LRB-
cord-022353-q2k2krnm	1385	24	SD	sd	NN
cord-022353-q2k2krnm	1385	25	)	)	-RRB-
cord-022353-q2k2krnm	1385	26	mEq/1	mEq/1	NNP
cord-022353-q2k2krnm	1385	27	(	(	-LRB-
cord-022353-q2k2krnm	1385	28	Finch	Finch	NNP
cord-022353-q2k2krnm	1385	29	and	and	CC
cord-022353-q2k2krnm	1385	30	Foster	Foster	NNP
cord-022353-q2k2krnm	1385	31	1973	1973	CD
cord-022353-q2k2krnm	1385	32	)	)	-RRB-
cord-022353-q2k2krnm	1385	33	,	,	,
cord-022353-q2k2krnm	1385	34	147	147	CD
cord-022353-q2k2krnm	1385	35	+	+	SYM
cord-022353-q2k2krnm	1385	36	15	15	CD
cord-022353-q2k2krnm	1386	1	(	(	-LRB-
cord-022353-q2k2krnm	1386	2	SD	SD	NNP
cord-022353-q2k2krnm	1386	3	)	)	-RRB-
cord-022353-q2k2krnm	1386	4	mEq	mEq	NNS
cord-022353-q2k2krnm	1386	5	/	/	SYM
cord-022353-q2k2krnm	1386	6	L	L	NNP
cord-022353-q2k2krnm	1386	7	(	(	-LRB-
cord-022353-q2k2krnm	1386	8	Everett	Everett	NNP
cord-022353-q2k2krnm	1386	9	and	and	CC
cord-022353-q2k2krnm	1386	10	Harrison	Harrison	NNP
cord-022353-q2k2krnm	1386	11	1983	1983	CD
cord-022353-q2k2krnm	1386	12	)	)	-RRB-
cord-022353-q2k2krnm	1386	13	,	,	,
cord-022353-q2k2krnm	1386	14	and	and	CC
cord-022353-q2k2krnm	1386	15	155	155	CD
cord-022353-q2k2krnm	1386	16	-	-	SYM
cord-022353-q2k2krnm	1386	17	161	161	CD
cord-022353-q2k2krnm	1386	18	mEq/1	mEq/1	NNP
cord-022353-q2k2krnm	1386	19	(	(	-LRB-
cord-022353-q2k2krnm	1386	20	Loeb	Loeb	NNP
cord-022353-q2k2krnm	1386	21	et	et	NNP
cord-022353-q2k2krnm	1386	22	al	al	NNP
cord-022353-q2k2krnm	1386	23	.	.	.
cord-022353-q2k2krnm	1386	24	1996	1996	CD
cord-022353-q2k2krnm	1386	25	)	)	-RRB-
cord-022353-q2k2krnm	1386	26	.	.	.
cord-022353-q2k2krnm	1387	1	No	no	DT
cord-022353-q2k2krnm	1387	2	differences	difference	NNS
cord-022353-q2k2krnm	1387	3	in	in	IN
cord-022353-q2k2krnm	1387	4	serum	serum	NN
cord-022353-q2k2krnm	1387	5	sodium	sodium	NN
cord-022353-q2k2krnm	1387	6	were	be	VBD
cord-022353-q2k2krnm	1387	7	seen	see	VBN
cord-022353-q2k2krnm	1387	8	during	during	IN
cord-022353-q2k2krnm	1387	9	aging	age	VBG
cord-022353-q2k2krnm	1387	10	,	,	,
cord-022353-q2k2krnm	1387	11	between	between	IN
cord-022353-q2k2krnm	1387	12	sexes	sex	NNS
cord-022353-q2k2krnm	1387	13	,	,	,
cord-022353-q2k2krnm	1387	14	or	or	CC
cord-022353-q2k2krnm	1387	15	among	among	IN
cord-022353-q2k2krnm	1387	16	strains	strain	NNS
cord-022353-q2k2krnm	1387	17	.	.	.
cord-022353-q2k2krnm	1388	1	Serum	serum	NN
cord-022353-q2k2krnm	1388	2	chloride	chloride	NN
cord-022353-q2k2krnm	1388	3	has	have	VBZ
cord-022353-q2k2krnm	1388	4	been	be	VBN
cord-022353-q2k2krnm	1388	5	measured	measure	VBN
cord-022353-q2k2krnm	1388	6	using	use	VBG
cord-022353-q2k2krnm	1388	7	mercuric	mercuric	NN
cord-022353-q2k2krnm	1388	8	thiocyanate	thiocyanate	NN
cord-022353-q2k2krnm	1388	9	and	and	CC
cord-022353-q2k2krnm	1388	10	the	the	DT
cord-022353-q2k2krnm	1388	11	chloridimetric	chloridimetric	NN
cord-022353-q2k2krnm	1388	12	or	or	CC
cord-022353-q2k2krnm	1388	13	ion	ion	NN
cord-022353-q2k2krnm	1388	14	-	-	HYPH
cord-022353-q2k2krnm	1388	15	specific	specific	JJ
cord-022353-q2k2krnm	1388	16	electrode	electrode	NN
cord-022353-q2k2krnm	1388	17	techniques	technique	NNS
cord-022353-q2k2krnm	1388	18	,	,	,
cord-022353-q2k2krnm	1388	19	and	and	CC
cord-022353-q2k2krnm	1388	20	inorganic	inorganic	JJ
cord-022353-q2k2krnm	1388	21	phosphorus	phosphorus	NN
cord-022353-q2k2krnm	1388	22	in	in	IN
cord-022353-q2k2krnm	1388	23	mice	mouse	NNS
cord-022353-q2k2krnm	1388	24	has	have	VBZ
cord-022353-q2k2krnm	1388	25	been	be	VBN
cord-022353-q2k2krnm	1388	26	measured	measure	VBN
cord-022353-q2k2krnm	1388	27	using	use	VBG
cord-022353-q2k2krnm	1388	28	the	the	DT
cord-022353-q2k2krnm	1388	29	phosphomolybdate	phosphomolybdate	JJ
cord-022353-q2k2krnm	1388	30	technique	technique	NN
cord-022353-q2k2krnm	1388	31	.	.	.
cord-022353-q2k2krnm	1389	1	Serum	serum	NN
cord-022353-q2k2krnm	1389	2	inorganic	inorganic	JJ
cord-022353-q2k2krnm	1389	3	phosphorus	phosphorus	NN
cord-022353-q2k2krnm	1389	4	levels	level	NNS
cord-022353-q2k2krnm	1389	5	decreased	decrease	VBD
cord-022353-q2k2krnm	1389	6	as	as	IN
cord-022353-q2k2krnm	1389	7	mice	mouse	NNS
cord-022353-q2k2krnm	1389	8	aged	age	VBN
cord-022353-q2k2krnm	1389	9	between	between	IN
cord-022353-q2k2krnm	1389	10	1	1	CD
cord-022353-q2k2krnm	1389	11	and	and	CC
cord-022353-q2k2krnm	1389	12	12	12	CD
cord-022353-q2k2krnm	1389	13	months	month	NNS
cord-022353-q2k2krnm	1389	14	.	.	.
cord-022353-q2k2krnm	1390	1	This	this	DT
cord-022353-q2k2krnm	1390	2	change	change	NN
cord-022353-q2k2krnm	1390	3	was	be	VBD
cord-022353-q2k2krnm	1390	4	documented	document	VBN
cord-022353-q2k2krnm	1390	5	in	in	IN
cord-022353-q2k2krnm	1390	6	BALB	BALB	NNP
cord-022353-q2k2krnm	1390	7	/	/	SYM
cord-022353-q2k2krnm	1390	8	c	c	NN
cord-022353-q2k2krnm	1390	9	and	and	CC
cord-022353-q2k2krnm	1390	10	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1390	11	strains	strain	NNS
cord-022353-q2k2krnm	1390	12	,	,	,
cord-022353-q2k2krnm	1390	13	as	as	RB
cord-022353-q2k2krnm	1390	14	well	well	RB
cord-022353-q2k2krnm	1390	15	as	as	IN
cord-022353-q2k2krnm	1390	16	in	in	IN
cord-022353-q2k2krnm	1390	17	outbred	outbred	JJ
cord-022353-q2k2krnm	1390	18	mice	mouse	NNS
cord-022353-q2k2krnm	1390	19	(	(	-LRB-
cord-022353-q2k2krnm	1390	20	Loeb	Loeb	NNP
cord-022353-q2k2krnm	1390	21	et	et	NNP
cord-022353-q2k2krnm	1390	22	al	al	NNP
cord-022353-q2k2krnm	1390	23	.	.	.
cord-022353-q2k2krnm	1390	24	1996	1996	CD
cord-022353-q2k2krnm	1390	25	)	)	-RRB-
cord-022353-q2k2krnm	1390	26	.	.	.
cord-022353-q2k2krnm	1391	1	Total	total	JJ
cord-022353-q2k2krnm	1391	2	serum	serum	NN
cord-022353-q2k2krnm	1391	3	calcium	calcium	NN
cord-022353-q2k2krnm	1391	4	reflects	reflect	VBZ
cord-022353-q2k2krnm	1391	5	both	both	DT
cord-022353-q2k2krnm	1391	6	ionized	ionized	JJ
cord-022353-q2k2krnm	1391	7	(	(	-LRB-
cord-022353-q2k2krnm	1391	8	active	active	JJ
cord-022353-q2k2krnm	1391	9	calcium	calcium	NN
cord-022353-q2k2krnm	1391	10	)	)	-RRB-
cord-022353-q2k2krnm	1391	11	and	and	CC
cord-022353-q2k2krnm	1391	12	protein	protein	NN
cord-022353-q2k2krnm	1391	13	-	-	HYPH
cord-022353-q2k2krnm	1391	14	bound	bind	VBN
cord-022353-q2k2krnm	1391	15	calcium	calcium	NN
cord-022353-q2k2krnm	1391	16	(	(	-LRB-
cord-022353-q2k2krnm	1391	17	mainly	mainly	RB
cord-022353-q2k2krnm	1391	18	bound	bind	VBN
cord-022353-q2k2krnm	1391	19	to	to	IN
cord-022353-q2k2krnm	1391	20	albumin	albumin	NN
cord-022353-q2k2krnm	1391	21	)	)	-RRB-
cord-022353-q2k2krnm	1391	22	.	.	.
cord-022353-q2k2krnm	1392	1	Ionized	ionized	JJ
cord-022353-q2k2krnm	1392	2	calcium	calcium	NN
cord-022353-q2k2krnm	1392	3	is	be	VBZ
cord-022353-q2k2krnm	1392	4	biologically	biologically	RB
cord-022353-q2k2krnm	1392	5	active	active	JJ
cord-022353-q2k2krnm	1392	6	in	in	IN
cord-022353-q2k2krnm	1392	7	bone	bone	NN
cord-022353-q2k2krnm	1392	8	formation	formation	NN
cord-022353-q2k2krnm	1392	9	,	,	,
cord-022353-q2k2krnm	1392	10	neuromuscular	neuromuscular	JJ
cord-022353-q2k2krnm	1392	11	activity	activity	NN
cord-022353-q2k2krnm	1392	12	,	,	,
cord-022353-q2k2krnm	1392	13	cellular	cellular	JJ
cord-022353-q2k2krnm	1392	14	biochemical	biochemical	JJ
cord-022353-q2k2krnm	1392	15	processes	process	NNS
cord-022353-q2k2krnm	1392	16	,	,	,
cord-022353-q2k2krnm	1392	17	and	and	CC
cord-022353-q2k2krnm	1392	18	blood	blood	NN
cord-022353-q2k2krnm	1392	19	coagulation	coagulation	NN
cord-022353-q2k2krnm	1392	20	.	.	.
cord-022353-q2k2krnm	1393	1	Decreased	decrease	VBN
cord-022353-q2k2krnm	1393	2	serum	serum	NN
cord-022353-q2k2krnm	1393	3	albumin	albumin	NN
cord-022353-q2k2krnm	1393	4	levels	level	NNS
cord-022353-q2k2krnm	1393	5	are	be	VBP
cord-022353-q2k2krnm	1393	6	also	also	RB
cord-022353-q2k2krnm	1393	7	expected	expect	VBN
cord-022353-q2k2krnm	1393	8	to	to	TO
cord-022353-q2k2krnm	1393	9	decrease	decrease	VB
cord-022353-q2k2krnm	1393	10	total	total	JJ
cord-022353-q2k2krnm	1393	11	calcium	calcium	NN
cord-022353-q2k2krnm	1393	12	levels	level	NNS
cord-022353-q2k2krnm	1393	13	,	,	,
cord-022353-q2k2krnm	1393	14	by	by	IN
cord-022353-q2k2krnm	1393	15	decreasing	decrease	VBG
cord-022353-q2k2krnm	1393	16	the	the	DT
cord-022353-q2k2krnm	1393	17	amount	amount	NN
cord-022353-q2k2krnm	1393	18	of	of	IN
cord-022353-q2k2krnm	1393	19	protein	protein	NN
cord-022353-q2k2krnm	1393	20	-	-	HYPH
cord-022353-q2k2krnm	1393	21	bound	bind	VBN
cord-022353-q2k2krnm	1393	22	calcium	calcium	NN
cord-022353-q2k2krnm	1393	23	.	.	.
cord-022353-q2k2krnm	1394	1	However	however	RB
cord-022353-q2k2krnm	1394	2	,	,	,
cord-022353-q2k2krnm	1394	3	hypoalbuminemia	hypoalbuminemia	NNP
cord-022353-q2k2krnm	1394	4	does	do	VBZ
cord-022353-q2k2krnm	1394	5	not	not	RB
cord-022353-q2k2krnm	1394	6	result	result	VB
cord-022353-q2k2krnm	1394	7	in	in	IN
cord-022353-q2k2krnm	1394	8	clinical	clinical	JJ
cord-022353-q2k2krnm	1394	9	signs	sign	NNS
cord-022353-q2k2krnm	1394	10	of	of	IN
cord-022353-q2k2krnm	1394	11	hypocalcemia	hypocalcemia	NN
cord-022353-q2k2krnm	1394	12	.	.	.
cord-022353-q2k2krnm	1395	1	In	in	IN
cord-022353-q2k2krnm	1395	2	mice	mouse	NNS
cord-022353-q2k2krnm	1395	3	,	,	,
cord-022353-q2k2krnm	1395	4	total	total	JJ
cord-022353-q2k2krnm	1395	5	serum	serum	NN
cord-022353-q2k2krnm	1395	6	calcium	calcium	NN
cord-022353-q2k2krnm	1395	7	has	have	VBZ
cord-022353-q2k2krnm	1395	8	been	be	VBN
cord-022353-q2k2krnm	1395	9	measured	measure	VBN
cord-022353-q2k2krnm	1395	10	using	use	VBG
cord-022353-q2k2krnm	1395	11	the	the	DT
cord-022353-q2k2krnm	1395	12	sodium	sodium	NN
cord-022353-q2k2krnm	1395	13	alizarin	alizarin	NN
cord-022353-q2k2krnm	1395	14	sulfonate	sulfonate	NN
cord-022353-q2k2krnm	1395	15	technique	technique	NN
cord-022353-q2k2krnm	1395	16	or	or	CC
cord-022353-q2k2krnm	1395	17	atomic	atomic	JJ
cord-022353-q2k2krnm	1395	18	absorption	absorption	NN
cord-022353-q2k2krnm	1395	19	spectrometry	spectrometry	NN
cord-022353-q2k2krnm	1395	20	.	.	.
cord-022353-q2k2krnm	1396	1	Two	two	CD
cord-022353-q2k2krnm	1396	2	reports	report	NNS
cord-022353-q2k2krnm	1396	3	,	,	,
cord-022353-q2k2krnm	1396	4	using	use	VBG
cord-022353-q2k2krnm	1396	5	different	different	JJ
cord-022353-q2k2krnm	1396	6	techniques	technique	NNS
cord-022353-q2k2krnm	1396	7	,	,	,
cord-022353-q2k2krnm	1396	8	list	list	VB
cord-022353-q2k2krnm	1396	9	similar	similar	JJ
cord-022353-q2k2krnm	1396	10	reference	reference	NN
cord-022353-q2k2krnm	1396	11	ranges	range	NNS
cord-022353-q2k2krnm	1396	12	of	of	IN
cord-022353-q2k2krnm	1396	13	9	9	CD
cord-022353-q2k2krnm	1396	14	+	+	SYM
cord-022353-q2k2krnm	1396	15	1	1	CD
cord-022353-q2k2krnm	1396	16	(	(	-LRB-
cord-022353-q2k2krnm	1396	17	SD	SD	NNP
cord-022353-q2k2krnm	1396	18	)	)	-RRB-
cord-022353-q2k2krnm	1396	19	mg	mg	NNP
cord-022353-q2k2krnm	1396	20	/	/	SYM
cord-022353-q2k2krnm	1396	21	dl	dl	NNP
cord-022353-q2k2krnm	1396	22	,	,	,
cord-022353-q2k2krnm	1396	23	whereas	whereas	IN
cord-022353-q2k2krnm	1396	24	a	a	DT
cord-022353-q2k2krnm	1396	25	third	third	JJ
cord-022353-q2k2krnm	1396	26	report	report	NN
cord-022353-q2k2krnm	1396	27	lists	list	VBZ
cord-022353-q2k2krnm	1396	28	reference	reference	NN
cord-022353-q2k2krnm	1396	29	ranges	range	NNS
cord-022353-q2k2krnm	1396	30	of	of	IN
cord-022353-q2k2krnm	1396	31	5.6	5.6	CD
cord-022353-q2k2krnm	1396	32	+	+	SYM
cord-022353-q2k2krnm	1396	33	0.4	0.4	CD
cord-022353-q2k2krnm	1397	1	(	(	-LRB-
cord-022353-q2k2krnm	1397	2	SD	SD	NNP
cord-022353-q2k2krnm	1397	3	)	)	-RRB-
cord-022353-q2k2krnm	1397	4	mg	mg	NNP
cord-022353-q2k2krnm	1397	5	/	/	SYM
cord-022353-q2k2krnm	1397	6	dl	dl	NNP
cord-022353-q2k2krnm	1397	7	for	for	IN
cord-022353-q2k2krnm	1397	8	male	male	NN
cord-022353-q2k2krnm	1397	9	and	and	CC
cord-022353-q2k2krnm	1397	10	7.4	7.4	CD
cord-022353-q2k2krnm	1397	11	+	+	SYM
cord-022353-q2k2krnm	1397	12	0.50	0.50	CD
cord-022353-q2k2krnm	1397	13	(	(	-LRB-
cord-022353-q2k2krnm	1397	14	SD	SD	NNP
cord-022353-q2k2krnm	1397	15	)	)	-RRB-
cord-022353-q2k2krnm	1397	16	mg	mg	NNP
cord-022353-q2k2krnm	1397	17	/	/	SYM
cord-022353-q2k2krnm	1397	18	dl	dl	NNP
cord-022353-q2k2krnm	1397	19	for	for	IN
cord-022353-q2k2krnm	1397	20	female	female	JJ
cord-022353-q2k2krnm	1397	21	albino	albino	NN
cord-022353-q2k2krnm	1397	22	mice	mouse	NNS
cord-022353-q2k2krnm	1397	23	.	.	.
cord-022353-q2k2krnm	1398	1	The	the	DT
cord-022353-q2k2krnm	1398	2	latter	latter	JJ
cord-022353-q2k2krnm	1398	3	values	value	NNS
cord-022353-q2k2krnm	1398	4	reported	report	VBN
cord-022353-q2k2krnm	1398	5	for	for	IN
cord-022353-q2k2krnm	1398	6	male	male	JJ
cord-022353-q2k2krnm	1398	7	mice	mouse	NNS
cord-022353-q2k2krnm	1398	8	were	be	VBD
cord-022353-q2k2krnm	1398	9	significantly	significantly	RB
cord-022353-q2k2krnm	1398	10	lower	low	JJR
cord-022353-q2k2krnm	1398	11	than	than	IN
cord-022353-q2k2krnm	1398	12	those	those	DT
cord-022353-q2k2krnm	1398	13	for	for	IN
cord-022353-q2k2krnm	1398	14	six	six	CD
cord-022353-q2k2krnm	1398	15	inbred	inbred	JJ
cord-022353-q2k2krnm	1398	16	strains	strain	NNS
cord-022353-q2k2krnm	1398	17	of	of	IN
cord-022353-q2k2krnm	1398	18	mice	mouse	NNS
cord-022353-q2k2krnm	1398	19	in	in	IN
cord-022353-q2k2krnm	1398	20	two	two	CD
cord-022353-q2k2krnm	1398	21	different	different	JJ
cord-022353-q2k2krnm	1398	22	age	age	NN
cord-022353-q2k2krnm	1398	23	-	-	HYPH
cord-022353-q2k2krnm	1398	24	groups	group	NNS
cord-022353-q2k2krnm	1398	25	using	use	VBG
cord-022353-q2k2krnm	1398	26	the	the	DT
cord-022353-q2k2krnm	1398	27	same	same	JJ
cord-022353-q2k2krnm	1398	28	techniques	technique	NNS
cord-022353-q2k2krnm	1398	29	(	(	-LRB-
cord-022353-q2k2krnm	1398	30	Quimby	Quimby	NNP
cord-022353-q2k2krnm	1398	31	1999b	1999b	CD
cord-022353-q2k2krnm	1398	32	)	)	-RRB-
cord-022353-q2k2krnm	1398	33	.	.	.
cord-022353-q2k2krnm	1399	1	Likewise	likewise	RB
cord-022353-q2k2krnm	1399	2	,	,	,
cord-022353-q2k2krnm	1399	3	no	no	DT
cord-022353-q2k2krnm	1399	4	differences	difference	NNS
cord-022353-q2k2krnm	1399	5	associated	associate	VBN
cord-022353-q2k2krnm	1399	6	with	with	IN
cord-022353-q2k2krnm	1399	7	sex	sex	NN
cord-022353-q2k2krnm	1399	8	were	be	VBD
cord-022353-q2k2krnm	1399	9	reported	report	VBN
cord-022353-q2k2krnm	1399	10	by	by	IN
cord-022353-q2k2krnm	1399	11	Everett	Everett	NNP
cord-022353-q2k2krnm	1399	12	and	and	CC
cord-022353-q2k2krnm	1399	13	Harrison	Harrison	NNP
cord-022353-q2k2krnm	1399	14	(	(	-LRB-
cord-022353-q2k2krnm	1399	15	1983	1983	CD
cord-022353-q2k2krnm	1399	16	)	)	-RRB-
cord-022353-q2k2krnm	1399	17	,	,	,
cord-022353-q2k2krnm	1399	18	who	who	WP
cord-022353-q2k2krnm	1399	19	also	also	RB
cord-022353-q2k2krnm	1399	20	examined	examine	VBD
cord-022353-q2k2krnm	1399	21	random	random	JJ
cord-022353-q2k2krnm	1399	22	bred	breed	VBN
cord-022353-q2k2krnm	1399	23	albino	albino	JJ
cord-022353-q2k2krnm	1399	24	mice	mouse	NNS
cord-022353-q2k2krnm	1399	25	.	.	.
cord-022353-q2k2krnm	1400	1	However	however	RB
cord-022353-q2k2krnm	1400	2	,	,	,
cord-022353-q2k2krnm	1400	3	Bonella	Bonella	NNP
cord-022353-q2k2krnm	1400	4	et	et	NNP
cord-022353-q2k2krnm	1400	5	al	al	NNP
cord-022353-q2k2krnm	1400	6	.	.	.
cord-022353-q2k2krnm	1401	1	(	(	-LRB-
cord-022353-q2k2krnm	1401	2	1968	1968	CD
cord-022353-q2k2krnm	1401	3	)	)	-RRB-
cord-022353-q2k2krnm	1401	4	demonstrated	demonstrate	VBD
cord-022353-q2k2krnm	1401	5	significantly	significantly	RB
cord-022353-q2k2krnm	1401	6	higher	high	JJR
cord-022353-q2k2krnm	1401	7	levels	level	NNS
cord-022353-q2k2krnm	1401	8	in	in	IN
cord-022353-q2k2krnm	1401	9	female	female	JJ
cord-022353-q2k2krnm	1401	10	Swiss	swiss	JJ
cord-022353-q2k2krnm	1401	11	albino	albino	NN
cord-022353-q2k2krnm	1401	12	mice	mouse	NNS
cord-022353-q2k2krnm	1401	13	.	.	.
cord-022353-q2k2krnm	1402	1	Serum	serum	NN
cord-022353-q2k2krnm	1402	2	calcium	calcium	NN
cord-022353-q2k2krnm	1402	3	levels	level	NNS
cord-022353-q2k2krnm	1402	4	appear	appear	VBP
cord-022353-q2k2krnm	1402	5	to	to	TO
cord-022353-q2k2krnm	1402	6	decline	decline	VB
cord-022353-q2k2krnm	1402	7	between	between	IN
cord-022353-q2k2krnm	1402	8	3	3	CD
cord-022353-q2k2krnm	1402	9	and	and	CC
cord-022353-q2k2krnm	1402	10	12	12	CD
cord-022353-q2k2krnm	1402	11	months	month	NNS
cord-022353-q2k2krnm	1402	12	of	of	IN
cord-022353-q2k2krnm	1402	13	age	age	NN
cord-022353-q2k2krnm	1402	14	in	in	IN
cord-022353-q2k2krnm	1402	15	the	the	DT
cord-022353-q2k2krnm	1402	16	BALB	BALB	NNP
cord-022353-q2k2krnm	1402	17	/	/	SYM
cord-022353-q2k2krnm	1402	18	c	c	NN
cord-022353-q2k2krnm	1402	19	and	and	CC
cord-022353-q2k2krnm	1402	20	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1402	21	strains	strain	NNS
cord-022353-q2k2krnm	1402	22	as	as	RB
cord-022353-q2k2krnm	1402	23	well	well	RB
cord-022353-q2k2krnm	1402	24	as	as	IN
cord-022353-q2k2krnm	1402	25	in	in	IN
cord-022353-q2k2krnm	1402	26	outbred	outbred	JJ
cord-022353-q2k2krnm	1402	27	mice	mouse	NNS
cord-022353-q2k2krnm	1402	28	.	.	.
cord-022353-q2k2krnm	1403	1	Frith	Frith	NNP
cord-022353-q2k2krnm	1403	2	et	et	NNP
cord-022353-q2k2krnm	1403	3	al	al	NNP
cord-022353-q2k2krnm	1403	4	.	.	.
cord-022353-q2k2krnm	1404	1	(	(	-LRB-
cord-022353-q2k2krnm	1404	2	1980	1980	CD
cord-022353-q2k2krnm	1404	3	)	)	-RRB-
cord-022353-q2k2krnm	1404	4	found	find	VBD
cord-022353-q2k2krnm	1404	5	that	that	IN
cord-022353-q2k2krnm	1404	6	female	female	JJ
cord-022353-q2k2krnm	1404	7	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1404	8	mice	mouse	NNS
cord-022353-q2k2krnm	1404	9	had	have	VBD
cord-022353-q2k2krnm	1404	10	lower	low	JJR
cord-022353-q2k2krnm	1404	11	calcium	calcium	NN
cord-022353-q2k2krnm	1404	12	levels	level	NNS
cord-022353-q2k2krnm	1404	13	than	than	IN
cord-022353-q2k2krnm	1404	14	males	male	NNS
cord-022353-q2k2krnm	1404	15	.	.	.
cord-022353-q2k2krnm	1405	1	Bonella	Bonella	NNP
cord-022353-q2k2krnm	1405	2	et	et	NNP
cord-022353-q2k2krnm	1405	3	al	al	NNP
cord-022353-q2k2krnm	1405	4	.	.	.
cord-022353-q2k2krnm	1406	1	(	(	-LRB-
cord-022353-q2k2krnm	1406	2	1968	1968	CD
cord-022353-q2k2krnm	1406	3	)	)	-RRB-
cord-022353-q2k2krnm	1406	4	demonstrated	demonstrate	VBD
cord-022353-q2k2krnm	1406	5	significantly	significantly	RB
cord-022353-q2k2krnm	1406	6	elevated	elevated	JJ
cord-022353-q2k2krnm	1406	7	calcium	calcium	NN
cord-022353-q2k2krnm	1406	8	levels	level	NNS
cord-022353-q2k2krnm	1406	9	when	when	WRB
cord-022353-q2k2krnm	1406	10	blood	blood	NN
cord-022353-q2k2krnm	1406	11	was	be	VBD
cord-022353-q2k2krnm	1406	12	collected	collect	VBN
cord-022353-q2k2krnm	1406	13	by	by	IN
cord-022353-q2k2krnm	1406	14	orbital	orbital	JJ
cord-022353-q2k2krnm	1406	15	puncture	puncture	NN
cord-022353-q2k2krnm	1406	16	versus	versus	IN
cord-022353-q2k2krnm	1406	17	cardiac	cardiac	JJ
cord-022353-q2k2krnm	1406	18	puncture	puncture	NN
cord-022353-q2k2krnm	1406	19	.	.	.
cord-022353-q2k2krnm	1407	1	Hypercalcemia	hypercalcemia	NN
cord-022353-q2k2krnm	1407	2	in	in	IN
cord-022353-q2k2krnm	1407	3	mice	mouse	NNS
cord-022353-q2k2krnm	1407	4	can	can	MD
cord-022353-q2k2krnm	1407	5	results	results	VB
cord-022353-q2k2krnm	1407	6	as	as	IN
cord-022353-q2k2krnm	1407	7	a	a	DT
cord-022353-q2k2krnm	1407	8	response	response	NN
cord-022353-q2k2krnm	1407	9	to	to	IN
cord-022353-q2k2krnm	1407	10	increased	increase	VBN
cord-022353-q2k2krnm	1407	11	levels	level	NNS
cord-022353-q2k2krnm	1407	12	of	of	IN
cord-022353-q2k2krnm	1407	13	PTH	PTH	NNP
cord-022353-q2k2krnm	1407	14	(	(	-LRB-
cord-022353-q2k2krnm	1407	15	such	such	JJ
cord-022353-q2k2krnm	1407	16	as	as	IN
cord-022353-q2k2krnm	1407	17	with	with	IN
cord-022353-q2k2krnm	1407	18	hyperparathyroidism	hyperparathyroidism	NN
cord-022353-q2k2krnm	1407	19	)	)	-RRB-
cord-022353-q2k2krnm	1407	20	or	or	CC
cord-022353-q2k2krnm	1407	21	PTHrP	PTHrP	NNP
cord-022353-q2k2krnm	1407	22	(	(	-LRB-
cord-022353-q2k2krnm	1407	23	such	such	JJ
cord-022353-q2k2krnm	1407	24	as	as	IN
cord-022353-q2k2krnm	1407	25	with	with	IN
cord-022353-q2k2krnm	1407	26	certain	certain	JJ
cord-022353-q2k2krnm	1407	27	neoplasms	neoplasm	NNS
cord-022353-q2k2krnm	1407	28	like	like	IN
cord-022353-q2k2krnm	1407	29	multiple	multiple	JJ
cord-022353-q2k2krnm	1407	30	myeloma	myeloma	NN
cord-022353-q2k2krnm	1407	31	)	)	-RRB-
cord-022353-q2k2krnm	1407	32	.	.	.
cord-022353-q2k2krnm	1408	1	In	in	IN
cord-022353-q2k2krnm	1408	2	mice	mouse	NNS
cord-022353-q2k2krnm	1408	3	,	,	,
cord-022353-q2k2krnm	1408	4	the	the	DT
cord-022353-q2k2krnm	1408	5	response	response	NN
cord-022353-q2k2krnm	1408	6	of	of	IN
cord-022353-q2k2krnm	1408	7	parathyroid	parathyroid	JJ
cord-022353-q2k2krnm	1408	8	chief	chief	NN
cord-022353-q2k2krnm	1408	9	cells	cell	NNS
cord-022353-q2k2krnm	1408	10	to	to	IN
cord-022353-q2k2krnm	1408	11	hypercalcemia	hypercalcemia	NN
cord-022353-q2k2krnm	1408	12	appears	appear	VBZ
cord-022353-q2k2krnm	1408	13	different	different	JJ
cord-022353-q2k2krnm	1408	14	from	from	IN
cord-022353-q2k2krnm	1408	15	other	other	JJ
cord-022353-q2k2krnm	1408	16	species	specie	NNS
cord-022353-q2k2krnm	1408	17	.	.	.
cord-022353-q2k2krnm	1409	1	Grone	Grone	NNP
cord-022353-q2k2krnm	1409	2	et	et	FW
cord-022353-q2k2krnm	1409	3	al	al	NNP
cord-022353-q2k2krnm	1409	4	.	.	.
cord-022353-q2k2krnm	1410	1	(	(	-LRB-
cord-022353-q2k2krnm	1410	2	1992	1992	CD
cord-022353-q2k2krnm	1410	3	)	)	-RRB-
cord-022353-q2k2krnm	1410	4	studied	study	VBD
cord-022353-q2k2krnm	1410	5	this	this	DT
cord-022353-q2k2krnm	1410	6	response	response	NN
cord-022353-q2k2krnm	1410	7	in	in	IN
cord-022353-q2k2krnm	1410	8	nude	nude	JJ
cord-022353-q2k2krnm	1410	9	mice	mouse	NNS
cord-022353-q2k2krnm	1410	10	with	with	IN
cord-022353-q2k2krnm	1410	11	PTHrP	pthrp	CD
cord-022353-q2k2krnm	1410	12	secreting	secrete	VBG
cord-022353-q2k2krnm	1410	13	tumor	tumor	NN
cord-022353-q2k2krnm	1410	14	cells	cell	NNS
cord-022353-q2k2krnm	1410	15	or	or	CC
cord-022353-q2k2krnm	1410	16	infusions	infusion	NNS
cord-022353-q2k2krnm	1410	17	of	of	IN
cord-022353-q2k2krnm	1410	18	PTHrP	PTHrP	NNP
cord-022353-q2k2krnm	1410	19	,	,	,
cord-022353-q2k2krnm	1410	20	and	and	CC
cord-022353-q2k2krnm	1410	21	found	find	VBD
cord-022353-q2k2krnm	1410	22	prominent	prominent	JJ
cord-022353-q2k2krnm	1410	23	membranous	membranous	JJ
cord-022353-q2k2krnm	1410	24	whorls	whorl	NNS
cord-022353-q2k2krnm	1410	25	and	and	CC
cord-022353-q2k2krnm	1410	26	increased	increase	VBN
cord-022353-q2k2krnm	1410	27	cytoplasmic	cytoplasmic	JJ
cord-022353-q2k2krnm	1410	28	area	area	NN
cord-022353-q2k2krnm	1410	29	of	of	IN
cord-022353-q2k2krnm	1410	30	chief	chief	JJ
cord-022353-q2k2krnm	1410	31	cells	cell	NNS
cord-022353-q2k2krnm	1410	32	in	in	IN
cord-022353-q2k2krnm	1410	33	mice	mouse	NNS
cord-022353-q2k2krnm	1410	34	with	with	IN
cord-022353-q2k2krnm	1410	35	hypercalcemia	hypercalcemia	NN
cord-022353-q2k2krnm	1410	36	(	(	-LRB-
cord-022353-q2k2krnm	1410	37	17.0	17.0	CD
cord-022353-q2k2krnm	1410	38	+	+	SYM
cord-022353-q2k2krnm	1410	39	3.1	3.1	CD
cord-022353-q2k2krnm	1410	40	mg	mg	NNP
cord-022353-q2k2krnm	1410	41	/	/	SYM
cord-022353-q2k2krnm	1410	42	dl	dl	NNP
cord-022353-q2k2krnm	1410	43	)	)	-RRB-
cord-022353-q2k2krnm	1410	44	,	,	,
cord-022353-q2k2krnm	1410	45	which	which	WDT
cord-022353-q2k2krnm	1410	46	marked	mark	VBD
cord-022353-q2k2krnm	1410	47	these	these	DT
cord-022353-q2k2krnm	1410	48	cells	cell	NNS
cord-022353-q2k2krnm	1410	49	as	as	RB
cord-022353-q2k2krnm	1410	50	distinctly	distinctly	RB
cord-022353-q2k2krnm	1410	51	different	different	JJ
cord-022353-q2k2krnm	1410	52	from	from	IN
cord-022353-q2k2krnm	1410	53	parathyroid	parathyroid	JJ
cord-022353-q2k2krnm	1410	54	chief	chief	JJ
cord-022353-q2k2krnm	1410	55	cells	cell	NNS
cord-022353-q2k2krnm	1410	56	of	of	IN
cord-022353-q2k2krnm	1410	57	other	other	JJ
cord-022353-q2k2krnm	1410	58	species	specie	NNS
cord-022353-q2k2krnm	1410	59	.	.	.
cord-022353-q2k2krnm	1411	1	Hypocalcemia	Hypocalcemia	NNP
cord-022353-q2k2krnm	1411	2	can	can	MD
cord-022353-q2k2krnm	1411	3	be	be	VB
cord-022353-q2k2krnm	1411	4	due	due	JJ
cord-022353-q2k2krnm	1411	5	to	to	IN
cord-022353-q2k2krnm	1411	6	hypoalbuminemia	hypoalbuminemia	NNP
cord-022353-q2k2krnm	1411	7	(	(	-LRB-
cord-022353-q2k2krnm	1411	8	as	as	RB
cord-022353-q2k2krnm	1411	9	previously	previously	RB
cord-022353-q2k2krnm	1411	10	discussed	discuss	VBN
cord-022353-q2k2krnm	1411	11	)	)	-RRB-
cord-022353-q2k2krnm	1411	12	,	,	,
cord-022353-q2k2krnm	1411	13	renal	renal	JJ
cord-022353-q2k2krnm	1411	14	disease	disease	NN
cord-022353-q2k2krnm	1411	15	,	,	,
cord-022353-q2k2krnm	1411	16	pancreatitis	pancreatitis	NN
cord-022353-q2k2krnm	1411	17	,	,	,
cord-022353-q2k2krnm	1411	18	and	and	CC
cord-022353-q2k2krnm	1411	19	hypomagnesemia	hypomagnesemia	NN
cord-022353-q2k2krnm	1411	20	.	.	.
cord-022353-q2k2krnm	1412	1	Alcock	Alcock	NNP
cord-022353-q2k2krnm	1412	2	and	and	CC
cord-022353-q2k2krnm	1412	3	Shils	Shils	NNP
cord-022353-q2k2krnm	1412	4	(	(	-LRB-
cord-022353-q2k2krnm	1412	5	1974	1974	CD
cord-022353-q2k2krnm	1412	6	)	)	-RRB-
cord-022353-q2k2krnm	1412	7	found	find	VBD
cord-022353-q2k2krnm	1412	8	that	that	IN
cord-022353-q2k2krnm	1412	9	mice	mouse	NNS
cord-022353-q2k2krnm	1412	10	fed	feed	VBD
cord-022353-q2k2krnm	1412	11	magnesium	magnesium	NN
cord-022353-q2k2krnm	1412	12	-	-	HYPH
cord-022353-q2k2krnm	1412	13	deficient	deficient	JJ
cord-022353-q2k2krnm	1412	14	diets	diet	NNS
cord-022353-q2k2krnm	1412	15	developed	develop	VBD
cord-022353-q2k2krnm	1412	16	hypocalcemia	hypocalcemia	NN
cord-022353-q2k2krnm	1412	17	,	,	,
cord-022353-q2k2krnm	1412	18	as	as	IN
cord-022353-q2k2krnm	1412	19	did	do	VBD
cord-022353-q2k2krnm	1412	20	mice	mouse	NNS
cord-022353-q2k2krnm	1412	21	receiving	receive	VBG
cord-022353-q2k2krnm	1412	22	intramuscular	intramuscular	JJ
cord-022353-q2k2krnm	1412	23	injections	injection	NNS
cord-022353-q2k2krnm	1412	24	of	of	IN
cord-022353-q2k2krnm	1412	25	heparin	heparin	NN
cord-022353-q2k2krnm	1412	26	.	.	.
cord-022353-q2k2krnm	1413	1	Total	total	JJ
cord-022353-q2k2krnm	1413	2	serum	serum	NN
cord-022353-q2k2krnm	1413	3	protein	protein	NN
cord-022353-q2k2krnm	1413	4	has	have	VBZ
cord-022353-q2k2krnm	1413	5	been	be	VBN
cord-022353-q2k2krnm	1413	6	evaluated	evaluate	VBN
cord-022353-q2k2krnm	1413	7	in	in	IN
cord-022353-q2k2krnm	1413	8	mice	mouse	NNS
cord-022353-q2k2krnm	1413	9	using	use	VBG
cord-022353-q2k2krnm	1413	10	either	either	CC
cord-022353-q2k2krnm	1413	11	the	the	DT
cord-022353-q2k2krnm	1413	12	Lowry	Lowry	NNP
cord-022353-q2k2krnm	1413	13	or	or	CC
cord-022353-q2k2krnm	1413	14	Biuret	Biuret	NNP
cord-022353-q2k2krnm	1413	15	methods	method	NNS
cord-022353-q2k2krnm	1413	16	,	,	,
cord-022353-q2k2krnm	1413	17	although	although	IN
cord-022353-q2k2krnm	1413	18	the	the	DT
cord-022353-q2k2krnm	1413	19	Lowry	Lowry	NNP
cord-022353-q2k2krnm	1413	20	method	method	NN
cord-022353-q2k2krnm	1413	21	is	be	VBZ
cord-022353-q2k2krnm	1413	22	preferred	prefer	VBN
cord-022353-q2k2krnm	1413	23	for	for	IN
cord-022353-q2k2krnm	1413	24	analysis	analysis	NN
cord-022353-q2k2krnm	1413	25	of	of	IN
cord-022353-q2k2krnm	1413	26	small	small	JJ
cord-022353-q2k2krnm	1413	27	volume	volume	NN
cord-022353-q2k2krnm	1413	28	samples	sample	NNS
cord-022353-q2k2krnm	1413	29	.	.	.
cord-022353-q2k2krnm	1414	1	Hypoproteinemia	Hypoproteinemia	NNP
cord-022353-q2k2krnm	1414	2	is	be	VBZ
cord-022353-q2k2krnm	1414	3	seen	see	VBN
cord-022353-q2k2krnm	1414	4	in	in	IN
cord-022353-q2k2krnm	1414	5	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1414	6	injury	injury	NN
cord-022353-q2k2krnm	1414	7	(	(	-LRB-
cord-022353-q2k2krnm	1414	8	also	also	RB
cord-022353-q2k2krnm	1414	9	see	see	VB
cord-022353-q2k2krnm	1414	10	the	the	DT
cord-022353-q2k2krnm	1414	11	"	"	``
cord-022353-q2k2krnm	1414	12	Liver	Liver	NNP
cord-022353-q2k2krnm	1414	13	Function	function	NN
cord-022353-q2k2krnm	1414	14	Tests	Tests	NNPS
cord-022353-q2k2krnm	1414	15	"	"	''
cord-022353-q2k2krnm	1414	16	section	section	NN
cord-022353-q2k2krnm	1414	17	)	)	-RRB-
cord-022353-q2k2krnm	1414	18	or	or	CC
cord-022353-q2k2krnm	1414	19	during	during	IN
cord-022353-q2k2krnm	1414	20	protein	protein	NN
cord-022353-q2k2krnm	1414	21	-	-	HYPH
cord-022353-q2k2krnm	1414	22	losing	lose	VBG
cord-022353-q2k2krnm	1414	23	enteropathies	enteropathy	NNS
cord-022353-q2k2krnm	1414	24	or	or	CC
cord-022353-q2k2krnm	1414	25	nephropathies	nephropathy	NNS
cord-022353-q2k2krnm	1414	26	.	.	.
cord-022353-q2k2krnm	1415	1	Hyperproteinemia	Hyperproteinemia	NNP
cord-022353-q2k2krnm	1415	2	is	be	VBZ
cord-022353-q2k2krnm	1415	3	seen	see	VBN
cord-022353-q2k2krnm	1415	4	during	during	IN
cord-022353-q2k2krnm	1415	5	dehydration	dehydration	NN
cord-022353-q2k2krnm	1415	6	.	.	.
cord-022353-q2k2krnm	1416	1	Age	age	NN
cord-022353-q2k2krnm	1416	2	-	-	HYPH
cord-022353-q2k2krnm	1416	3	related	relate	VBN
cord-022353-q2k2krnm	1416	4	changes	change	NNS
cord-022353-q2k2krnm	1416	5	have	have	VBP
cord-022353-q2k2krnm	1416	6	been	be	VBN
cord-022353-q2k2krnm	1416	7	described	describe	VBN
cord-022353-q2k2krnm	1416	8	in	in	IN
cord-022353-q2k2krnm	1416	9	a	a	DT
cord-022353-q2k2krnm	1416	10	number	number	NN
cord-022353-q2k2krnm	1416	11	of	of	IN
cord-022353-q2k2krnm	1416	12	strains	strain	NNS
cord-022353-q2k2krnm	1416	13	,	,	,
cord-022353-q2k2krnm	1416	14	such	such	JJ
cord-022353-q2k2krnm	1416	15	as	as	IN
cord-022353-q2k2krnm	1416	16	increased	increase	VBN
cord-022353-q2k2krnm	1416	17	total	total	JJ
cord-022353-q2k2krnm	1416	18	serum	serum	NN
cord-022353-q2k2krnm	1416	19	protein	protein	NN
cord-022353-q2k2krnm	1416	20	in	in	IN
cord-022353-q2k2krnm	1416	21	older	old	JJR
cord-022353-q2k2krnm	1416	22	BALB	BALB	NNP
cord-022353-q2k2krnm	1416	23	/	/	SYM
cord-022353-q2k2krnm	1416	24	c	c	NN
cord-022353-q2k2krnm	1416	25	and	and	CC
cord-022353-q2k2krnm	1416	26	B6	b6	NN
cord-022353-q2k2krnm	1416	27	mice	mouse	NNS
cord-022353-q2k2krnm	1416	28	and	and	CC
cord-022353-q2k2krnm	1416	29	lower	low	JJR
cord-022353-q2k2krnm	1416	30	levels	level	NNS
cord-022353-q2k2krnm	1416	31	in	in	IN
cord-022353-q2k2krnm	1416	32	DBA/2	DBA/2	NNP
cord-022353-q2k2krnm	1416	33	mice	mouse	NNS
cord-022353-q2k2krnm	1417	1	(	(	-LRB-
cord-022353-q2k2krnm	1417	2	Loeb	Loeb	NNP
cord-022353-q2k2krnm	1417	3	et	et	NNP
cord-022353-q2k2krnm	1417	4	al	al	NNP
cord-022353-q2k2krnm	1417	5	.	.	.
cord-022353-q2k2krnm	1417	6	1996	1996	CD
cord-022353-q2k2krnm	1417	7	)	)	-RRB-
cord-022353-q2k2krnm	1417	8	.	.	.
cord-022353-q2k2krnm	1418	1	Each	each	DT
cord-022353-q2k2krnm	1418	2	of	of	IN
cord-022353-q2k2krnm	1418	3	the	the	DT
cord-022353-q2k2krnm	1418	4	major	major	JJ
cord-022353-q2k2krnm	1418	5	classes	class	NNS
cord-022353-q2k2krnm	1418	6	of	of	IN
cord-022353-q2k2krnm	1418	7	serum	serum	NN
cord-022353-q2k2krnm	1418	8	protein	protein	NN
cord-022353-q2k2krnm	1418	9	(	(	-LRB-
cord-022353-q2k2krnm	1418	10	(	(	-LRB-
cord-022353-q2k2krnm	1419	1	xl-	xl-	UH
cord-022353-q2k2krnm	1419	2	,	,	,
cord-022353-q2k2krnm	1419	3	(	(	-LRB-
cord-022353-q2k2krnm	1419	4	x2-	x2-	NNP
cord-022353-q2k2krnm	1419	5	,	,	,
cord-022353-q2k2krnm	1419	6	~-	~-	NNP
cord-022353-q2k2krnm	1419	7	,	,	,
cord-022353-q2k2krnm	1419	8	and	and	CC
cord-022353-q2k2krnm	1419	9	y	y	NN
cord-022353-q2k2krnm	1419	10	-	-	HYPH
cord-022353-q2k2krnm	1419	11	globulins	globulins	NNP
cord-022353-q2k2krnm	1419	12	)	)	-RRB-
cord-022353-q2k2krnm	1419	13	in	in	IN
cord-022353-q2k2krnm	1419	14	mice	mouse	NNS
cord-022353-q2k2krnm	1419	15	can	can	MD
cord-022353-q2k2krnm	1419	16	be	be	VB
cord-022353-q2k2krnm	1419	17	distinguished	distinguish	VBN
cord-022353-q2k2krnm	1419	18	by	by	IN
cord-022353-q2k2krnm	1419	19	electrophoresis	electrophoresis	NN
cord-022353-q2k2krnm	1419	20	.	.	.
cord-022353-q2k2krnm	1420	1	Changes	change	NNS
cord-022353-q2k2krnm	1420	2	in	in	IN
cord-022353-q2k2krnm	1420	3	serum	serum	NN
cord-022353-q2k2krnm	1420	4	levels	level	NNS
cord-022353-q2k2krnm	1420	5	have	have	VBP
cord-022353-q2k2krnm	1420	6	been	be	VBN
cord-022353-q2k2krnm	1420	7	associated	associate	VBN
cord-022353-q2k2krnm	1420	8	with	with	IN
cord-022353-q2k2krnm	1420	9	a	a	DT
cord-022353-q2k2krnm	1420	10	wide	wide	JJ
cord-022353-q2k2krnm	1420	11	variety	variety	NN
cord-022353-q2k2krnm	1420	12	of	of	IN
cord-022353-q2k2krnm	1420	13	diseases	disease	NNS
cord-022353-q2k2krnm	1420	14	in	in	IN
cord-022353-q2k2krnm	1420	15	mice	mouse	NNS
cord-022353-q2k2krnm	1420	16	.	.	.
cord-022353-q2k2krnm	1421	1	For	for	IN
cord-022353-q2k2krnm	1421	2	instance	instance	NN
cord-022353-q2k2krnm	1421	3	,	,	,
cord-022353-q2k2krnm	1421	4	hypergammaglobulinemia	hypergammaglobulinemia	NNP
cord-022353-q2k2krnm	1421	5	was	be	VBD
cord-022353-q2k2krnm	1421	6	found	find	VBN
cord-022353-q2k2krnm	1421	7	in	in	IN
cord-022353-q2k2krnm	1421	8	SCID	SCID	NNP
cord-022353-q2k2krnm	1421	9	mice	mouse	NNS
cord-022353-q2k2krnm	1421	10	injected	inject	VBN
cord-022353-q2k2krnm	1421	11	with	with	IN
cord-022353-q2k2krnm	1421	12	human	human	JJ
cord-022353-q2k2krnm	1421	13	CAG	CAG	NNP
cord-022353-q2k2krnm	1421	14	multiple	multiple	JJ
cord-022353-q2k2krnm	1421	15	myeloma	myeloma	NN
cord-022353-q2k2krnm	1421	16	cells	cell	NNS
cord-022353-q2k2krnm	1421	17	.	.	.
cord-022353-q2k2krnm	1422	1	The	the	DT
cord-022353-q2k2krnm	1422	2	acute	acute	JJ
cord-022353-q2k2krnm	1422	3	phase	phase	NN
cord-022353-q2k2krnm	1422	4	reactants	reactant	NNS
cord-022353-q2k2krnm	1422	5	ceruloplasmin	ceruloplasmin	NNP
cord-022353-q2k2krnm	1422	6	and	and	CC
cord-022353-q2k2krnm	1422	7	fibrinogen	fibrinogen	NN
cord-022353-q2k2krnm	1422	8	have	have	VBP
cord-022353-q2k2krnm	1422	9	been	be	VBN
cord-022353-q2k2krnm	1422	10	discussed	discuss	VBN
cord-022353-q2k2krnm	1422	11	in	in	IN
cord-022353-q2k2krnm	1422	12	the	the	DT
cord-022353-q2k2krnm	1422	13	"	"	``
cord-022353-q2k2krnm	1422	14	Serum	Serum	NNP
cord-022353-q2k2krnm	1422	15	Proteins	protein	NNS
cord-022353-q2k2krnm	1422	16	"	"	''
cord-022353-q2k2krnm	1422	17	section	section	NN
cord-022353-q2k2krnm	1422	18	and	and	CC
cord-022353-q2k2krnm	1422	19	CRP	CRP	NNP
cord-022353-q2k2krnm	1422	20	and	and	CC
cord-022353-q2k2krnm	1422	21	SAP	SAP	NNP
cord-022353-q2k2krnm	1422	22	in	in	IN
cord-022353-q2k2krnm	1422	23	the	the	DT
cord-022353-q2k2krnm	1422	24	"	"	``
cord-022353-q2k2krnm	1422	25	Complement	complement	NN
cord-022353-q2k2krnm	1422	26	"	"	''
cord-022353-q2k2krnm	1422	27	section	section	NN
cord-022353-q2k2krnm	1422	28	.	.	.
cord-022353-q2k2krnm	1423	1	SAA	SAA	NNP
cord-022353-q2k2krnm	1423	2	is	be	VBZ
cord-022353-q2k2krnm	1423	3	an	an	DT
cord-022353-q2k2krnm	1423	4	acute	acute	JJ
cord-022353-q2k2krnm	1423	5	phase	phase	NN
cord-022353-q2k2krnm	1423	6	reactant	reactant	NN
cord-022353-q2k2krnm	1423	7	synthesized	synthesize	VBN
cord-022353-q2k2krnm	1423	8	by	by	IN
cord-022353-q2k2krnm	1423	9	the	the	DT
cord-022353-q2k2krnm	1423	10	liver	liver	NN
cord-022353-q2k2krnm	1423	11	and	and	CC
cord-022353-q2k2krnm	1423	12	may	may	MD
cord-022353-q2k2krnm	1423	13	be	be	VB
cord-022353-q2k2krnm	1423	14	induced	induce	VBN
cord-022353-q2k2krnm	1423	15	by	by	IN
cord-022353-q2k2krnm	1423	16	the	the	DT
cord-022353-q2k2krnm	1423	17	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	1423	18	cytokines	cytokine	NNS
cord-022353-q2k2krnm	1423	19	IL-1	IL-1	NNP
cord-022353-q2k2krnm	1423	20	or	or	CC
cord-022353-q2k2krnm	1423	21	IL-6	IL-6	NNP
cord-022353-q2k2krnm	1423	22	(	(	-LRB-
cord-022353-q2k2krnm	1423	23	see	see	VB
cord-022353-q2k2krnm	1423	24	the	the	DT
cord-022353-q2k2krnm	1423	25	"	"	``
cord-022353-q2k2krnm	1423	26	Cytokines	Cytokines	NNPS
cord-022353-q2k2krnm	1423	27	and	and	CC
cord-022353-q2k2krnm	1423	28	Chemokines	Chemokines	NNPS
cord-022353-q2k2krnm	1423	29	"	"	''
cord-022353-q2k2krnm	1423	30	section	section	NN
cord-022353-q2k2krnm	1423	31	)	)	-RRB-
cord-022353-q2k2krnm	1423	32	.	.	.
cord-022353-q2k2krnm	1424	1	Normally	normally	RB
cord-022353-q2k2krnm	1424	2	SAA	SAA	NNP
cord-022353-q2k2krnm	1424	3	is	be	VBZ
cord-022353-q2k2krnm	1424	4	quickly	quickly	RB
cord-022353-q2k2krnm	1424	5	cleaved	cleave	VBN
cord-022353-q2k2krnm	1424	6	to	to	IN
cord-022353-q2k2krnm	1424	7	a	a	DT
cord-022353-q2k2krnm	1424	8	small	small	JJ
cord-022353-q2k2krnm	1424	9	molecular	molecular	JJ
cord-022353-q2k2krnm	1424	10	weight	weight	NN
cord-022353-q2k2krnm	1424	11	product	product	NN
cord-022353-q2k2krnm	1424	12	,	,	,
cord-022353-q2k2krnm	1424	13	but	but	CC
cord-022353-q2k2krnm	1424	14	during	during	IN
cord-022353-q2k2krnm	1424	15	chronic	chronic	JJ
cord-022353-q2k2krnm	1424	16	infection	infection	NN
cord-022353-q2k2krnm	1424	17	or	or	CC
cord-022353-q2k2krnm	1424	18	failure	failure	NN
cord-022353-q2k2krnm	1424	19	in	in	IN
cord-022353-q2k2krnm	1424	20	the	the	DT
cord-022353-q2k2krnm	1424	21	degradation	degradation	NN
cord-022353-q2k2krnm	1424	22	pathway	pathway	NN
cord-022353-q2k2krnm	1424	23	,	,	,
cord-022353-q2k2krnm	1424	24	tissue	tissue	NN
cord-022353-q2k2krnm	1424	25	deposition	deposition	NN
cord-022353-q2k2krnm	1424	26	of	of	IN
cord-022353-q2k2krnm	1424	27	amyloid	amyloid	NN
cord-022353-q2k2krnm	1424	28	may	may	MD
cord-022353-q2k2krnm	1424	29	occur	occur	VB
cord-022353-q2k2krnm	1424	30	.	.	.
cord-022353-q2k2krnm	1425	1	Differences	difference	NNS
cord-022353-q2k2krnm	1425	2	in	in	IN
cord-022353-q2k2krnm	1425	3	serum	serum	NN
cord-022353-q2k2krnm	1425	4	concentrations	concentration	NNS
cord-022353-q2k2krnm	1425	5	have	have	VBP
cord-022353-q2k2krnm	1425	6	been	be	VBN
cord-022353-q2k2krnm	1425	7	described	describe	VBN
cord-022353-q2k2krnm	1425	8	in	in	IN
cord-022353-q2k2krnm	1425	9	various	various	JJ
cord-022353-q2k2krnm	1425	10	mouse	mouse	NN
cord-022353-q2k2krnm	1425	11	strains	strain	NNS
cord-022353-q2k2krnm	1425	12	and	and	CC
cord-022353-q2k2krnm	1425	13	during	during	IN
cord-022353-q2k2krnm	1425	14	disease	disease	NN
cord-022353-q2k2krnm	1425	15	.	.	.
cord-022353-q2k2krnm	1426	1	Commercial	Commercial	NNP
cord-022353-q2k2krnm	1426	2	RIA	RIA	NNP
cord-022353-q2k2krnm	1426	3	and	and	CC
cord-022353-q2k2krnm	1426	4	ELISA	ELISA	NNP
cord-022353-q2k2krnm	1426	5	kits	kit	NNS
cord-022353-q2k2krnm	1426	6	are	be	VBP
cord-022353-q2k2krnm	1426	7	available	available	JJ
cord-022353-q2k2krnm	1426	8	for	for	IN
cord-022353-q2k2krnm	1426	9	its	-PRON-	PRP$
cord-022353-q2k2krnm	1426	10	quantitation	quantitation	NN
cord-022353-q2k2krnm	1426	11	in	in	IN
cord-022353-q2k2krnm	1426	12	mice	mouse	NNS
cord-022353-q2k2krnm	1426	13	(	(	-LRB-
cord-022353-q2k2krnm	1426	14	Quimby	Quimby	NNP
cord-022353-q2k2krnm	1426	15	1999b	1999b	CD
cord-022353-q2k2krnm	1426	16	)	)	-RRB-
cord-022353-q2k2krnm	1426	17	.	.	.
cord-022353-q2k2krnm	1427	1	Alpha-1-fetoprotein	alpha-1-fetoprotein	VBP
cord-022353-q2k2krnm	1427	2	(	(	-LRB-
cord-022353-q2k2krnm	1427	3	AFP	AFP	NNP
cord-022353-q2k2krnm	1427	4	)	)	-RRB-
cord-022353-q2k2krnm	1427	5	is	be	VBZ
cord-022353-q2k2krnm	1427	6	encoded	encode	VBN
cord-022353-q2k2krnm	1427	7	by	by	IN
cord-022353-q2k2krnm	1427	8	the	the	DT
cord-022353-q2k2krnm	1427	9	Afp	Afp	NNP
cord-022353-q2k2krnm	1427	10	gene	gene	NN
cord-022353-q2k2krnm	1427	11	which	which	WDT
cord-022353-q2k2krnm	1427	12	is	be	VBZ
cord-022353-q2k2krnm	1427	13	nearly	nearly	RB
cord-022353-q2k2krnm	1427	14	identical	identical	JJ
cord-022353-q2k2krnm	1427	15	in	in	IN
cord-022353-q2k2krnm	1427	16	its	-PRON-	PRP$
cord-022353-q2k2krnm	1427	17	organization	organization	NN
cord-022353-q2k2krnm	1427	18	to	to	IN
cord-022353-q2k2krnm	1427	19	the	the	DT
cord-022353-q2k2krnm	1427	20	mouse	mouse	NN
cord-022353-q2k2krnm	1427	21	albumin	albumin	NN
cord-022353-q2k2krnm	1427	22	gene	gene	NN
cord-022353-q2k2krnm	1427	23	,	,	,
cord-022353-q2k2krnm	1427	24	Albl	Albl	NNP
cord-022353-q2k2krnm	1427	25	.	.	.
cord-022353-q2k2krnm	1428	1	It	-PRON-	PRP
cord-022353-q2k2krnm	1428	2	is	be	VBZ
cord-022353-q2k2krnm	1428	3	likely	likely	JJ
cord-022353-q2k2krnm	1428	4	Afp	Afp	NNP
cord-022353-q2k2krnm	1428	5	arose	arise	VBD
cord-022353-q2k2krnm	1428	6	due	due	IN
cord-022353-q2k2krnm	1428	7	to	to	IN
cord-022353-q2k2krnm	1428	8	gene	gene	NN
cord-022353-q2k2krnm	1428	9	duplication	duplication	NN
cord-022353-q2k2krnm	1428	10	.	.	.
cord-022353-q2k2krnm	1429	1	AFP	AFP	NNP
cord-022353-q2k2krnm	1429	2	is	be	VBZ
cord-022353-q2k2krnm	1429	3	present	present	JJ
cord-022353-q2k2krnm	1429	4	in	in	IN
cord-022353-q2k2krnm	1429	5	fetal	fetal	JJ
cord-022353-q2k2krnm	1429	6	serum	serum	NN
cord-022353-q2k2krnm	1429	7	but	but	CC
cord-022353-q2k2krnm	1429	8	the	the	DT
cord-022353-q2k2krnm	1429	9	synthesis	synthesis	NN
cord-022353-q2k2krnm	1429	10	declines	decline	VBZ
cord-022353-q2k2krnm	1429	11	shortly	shortly	RB
cord-022353-q2k2krnm	1429	12	after	after	IN
cord-022353-q2k2krnm	1429	13	birth	birth	NN
cord-022353-q2k2krnm	1429	14	.	.	.
cord-022353-q2k2krnm	1430	1	Serum	serum	NN
cord-022353-q2k2krnm	1430	2	levels	level	NNS
cord-022353-q2k2krnm	1430	3	are	be	VBP
cord-022353-q2k2krnm	1430	4	regulated	regulate	VBN
cord-022353-q2k2krnm	1430	5	by	by	IN
cord-022353-q2k2krnm	1430	6	two	two	CD
cord-022353-q2k2krnm	1430	7	loci	locus	NNS
cord-022353-q2k2krnm	1430	8	,	,	,
cord-022353-q2k2krnm	1430	9	Afr-1	Afr-1	NNP
cord-022353-q2k2krnm	1430	10	and	and	CC
cord-022353-q2k2krnm	1430	11	Afr-2	Afr-2	NNP
cord-022353-q2k2krnm	1430	12	,	,	,
cord-022353-q2k2krnm	1430	13	which	which	WDT
cord-022353-q2k2krnm	1430	14	are	be	VBP
cord-022353-q2k2krnm	1430	15	not	not	RB
cord-022353-q2k2krnm	1430	16	linked	link	VBN
cord-022353-q2k2krnm	1430	17	to	to	IN
cord-022353-q2k2krnm	1430	18	AFP	AFP	NNP
cord-022353-q2k2krnm	1430	19	.	.	.
cord-022353-q2k2krnm	1431	1	The	the	DT
cord-022353-q2k2krnm	1431	2	action	action	NN
cord-022353-q2k2krnm	1431	3	of	of	IN
cord-022353-q2k2krnm	1431	4	these	these	DT
cord-022353-q2k2krnm	1431	5	genes	gene	NNS
cord-022353-q2k2krnm	1431	6	may	may	MD
cord-022353-q2k2krnm	1431	7	be	be	VB
cord-022353-q2k2krnm	1431	8	modified	modify	VBN
cord-022353-q2k2krnm	1431	9	by	by	IN
cord-022353-q2k2krnm	1431	10	TGF-~	TGF-~	NNP
cord-022353-q2k2krnm	1431	11	and	and	CC
cord-022353-q2k2krnm	1431	12	p53	p53	NN
cord-022353-q2k2krnm	1432	1	(	(	-LRB-
cord-022353-q2k2krnm	1432	2	Wilkinson	Wilkinson	NNP
cord-022353-q2k2krnm	1432	3	et	et	NNP
cord-022353-q2k2krnm	1432	4	al	al	NNP
cord-022353-q2k2krnm	1432	5	.	.	NNP
cord-022353-q2k2krnm	1432	6	2005	2005	CD
cord-022353-q2k2krnm	1432	7	)	)	-RRB-
cord-022353-q2k2krnm	1432	8	.	.	.
cord-022353-q2k2krnm	1433	1	Levels	level	NNS
cord-022353-q2k2krnm	1433	2	in	in	IN
cord-022353-q2k2krnm	1433	3	mouse	mouse	NN
cord-022353-q2k2krnm	1433	4	serum	serum	NN
cord-022353-q2k2krnm	1433	5	have	have	VBP
cord-022353-q2k2krnm	1433	6	been	be	VBN
cord-022353-q2k2krnm	1433	7	quantified	quantify	VBN
cord-022353-q2k2krnm	1433	8	by	by	IN
cord-022353-q2k2krnm	1433	9	immunoelectrophoresis	immunoelectrophoresis	NN
cord-022353-q2k2krnm	1433	10	(	(	-LRB-
cord-022353-q2k2krnm	1433	11	Zizkovsky	Zizkovsky	NNP
cord-022353-q2k2krnm	1433	12	1975	1975	CD
cord-022353-q2k2krnm	1433	13	)	)	-RRB-
cord-022353-q2k2krnm	1433	14	and	and	CC
cord-022353-q2k2krnm	1433	15	both	both	DT
cord-022353-q2k2krnm	1433	16	polyclonal	polyclonal	JJ
cord-022353-q2k2krnm	1433	17	antibodies	antibody	NNS
cord-022353-q2k2krnm	1433	18	and	and	CC
cord-022353-q2k2krnm	1433	19	recombinant	recombinant	JJ
cord-022353-q2k2krnm	1433	20	DNA	dna	NN
cord-022353-q2k2krnm	1433	21	-	-	HYPH
cord-022353-q2k2krnm	1433	22	derived	derive	VBN
cord-022353-q2k2krnm	1433	23	mouse	mouse	NN
cord-022353-q2k2krnm	1433	24	AFP	AFP	NNP
cord-022353-q2k2krnm	1433	25	are	be	VBP
cord-022353-q2k2krnm	1433	26	available	available	JJ
cord-022353-q2k2krnm	1433	27	for	for	IN
cord-022353-q2k2krnm	1433	28	assay	assay	NN
cord-022353-q2k2krnm	1433	29	development	development	NN
cord-022353-q2k2krnm	1433	30	(	(	-LRB-
cord-022353-q2k2krnm	1433	31	Boismenu	Boismenu	NNP
cord-022353-q2k2krnm	1433	32	et	et	NNP
cord-022353-q2k2krnm	1433	33	al	al	NNP
cord-022353-q2k2krnm	1433	34	.	.	.
cord-022353-q2k2krnm	1433	35	1997	1997	CD
cord-022353-q2k2krnm	1433	36	)	)	-RRB-
cord-022353-q2k2krnm	1433	37	and	and	CC
cord-022353-q2k2krnm	1433	38	are	be	VBP
cord-022353-q2k2krnm	1433	39	elevated	elevate	VBN
cord-022353-q2k2krnm	1433	40	in	in	IN
cord-022353-q2k2krnm	1433	41	mice	mouse	NNS
cord-022353-q2k2krnm	1433	42	with	with	IN
cord-022353-q2k2krnm	1433	43	certain	certain	JJ
cord-022353-q2k2krnm	1433	44	neoplasms	neoplasm	NNS
cord-022353-q2k2krnm	1433	45	and	and	CC
cord-022353-q2k2krnm	1433	46	during	during	IN
cord-022353-q2k2krnm	1433	47	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1433	48	regeneration	regeneration	NN
cord-022353-q2k2krnm	1434	1	(	(	-LRB-
cord-022353-q2k2krnm	1434	2	Jin	Jin	NNP
cord-022353-q2k2krnm	1434	3	et	et	FW
cord-022353-q2k2krnm	1434	4	al	al	NNP
cord-022353-q2k2krnm	1434	5	.	.	.
cord-022353-q2k2krnm	1435	1	2005	2005	CD
cord-022353-q2k2krnm	1435	2	;	;	:
cord-022353-q2k2krnm	1435	3	Quimby	Quimby	NNP
cord-022353-q2k2krnm	1435	4	1999b	1999b	CD
cord-022353-q2k2krnm	1435	5	)	)	-RRB-
cord-022353-q2k2krnm	1435	6	.	.	.
cord-022353-q2k2krnm	1436	1	Sulphostin	Sulphostin	NNP
cord-022353-q2k2krnm	1436	2	,	,	,
cord-022353-q2k2krnm	1436	3	a	a	DT
cord-022353-q2k2krnm	1436	4	novel	novel	JJ
cord-022353-q2k2krnm	1436	5	inhibitor	inhibitor	NN
cord-022353-q2k2krnm	1436	6	of	of	IN
cord-022353-q2k2krnm	1436	7	dipeptidyl	dipeptidyl	NNP
cord-022353-q2k2krnm	1436	8	peptidases	peptidase	NNS
cord-022353-q2k2krnm	1436	9	IV	IV	NNP
cord-022353-q2k2krnm	1436	10	(	(	-LRB-
cord-022353-q2k2krnm	1436	11	DPPIV	DPPIV	NNP
cord-022353-q2k2krnm	1436	12	)	)	-RRB-
cord-022353-q2k2krnm	1436	13	that	that	WDT
cord-022353-q2k2krnm	1436	14	stimulates	stimulate	VBZ
cord-022353-q2k2krnm	1436	15	hematopoiesis	hematopoiesis	NN
cord-022353-q2k2krnm	1436	16	in	in	IN
cord-022353-q2k2krnm	1436	17	mice	mouse	NNS
cord-022353-q2k2krnm	1436	18	Proteomic	Proteomic	NNP
cord-022353-q2k2krnm	1436	19	approaches	approach	VBZ
cord-022353-q2k2krnm	1436	20	to	to	IN
cord-022353-q2k2krnm	1436	21	biomarker	biomarker	NN
cord-022353-q2k2krnm	1436	22	discovery	discovery	NN
cord-022353-q2k2krnm	1436	23	in	in	IN
cord-022353-q2k2krnm	1436	24	prostate	prostate	NN
cord-022353-q2k2krnm	1436	25	and	and	CC
cord-022353-q2k2krnm	1436	26	bladder	bladder	NN
cord-022353-q2k2krnm	1436	27	cancers	cancer	NNS
cord-022353-q2k2krnm	1437	1	8th	8th	JJ
cord-022353-q2k2krnm	1438	1	annual	annual	JJ
cord-022353-q2k2krnm	1438	2	analyzers	analyzer	NNS
cord-022353-q2k2krnm	1438	3	buyer	buyer	NN
cord-022353-q2k2krnm	1438	4	's	's	POS
cord-022353-q2k2krnm	1438	5	guide	guide	NN
cord-022353-q2k2krnm	1438	6	IL-17	IL-17	NNP
cord-022353-q2k2krnm	1438	7	:	:	:
cord-022353-q2k2krnm	1438	8	prototype	prototype	NN
cord-022353-q2k2krnm	1438	9	member	member	NN
cord-022353-q2k2krnm	1438	10	of	of	IN
cord-022353-q2k2krnm	1438	11	an	an	DT
cord-022353-q2k2krnm	1438	12	emerging	emerge	VBG
cord-022353-q2k2krnm	1438	13	cytokine	cytokine	NN
cord-022353-q2k2krnm	1438	14	family	family	NN
cord-022353-q2k2krnm	1439	1	Increased	increase	VBN
cord-022353-q2k2krnm	1439	2	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1439	3	in	in	IN
cord-022353-q2k2krnm	1439	4	hypeflipidemic	hypeflipidemic	NNP
cord-022353-q2k2krnm	1439	5	mice	mouse	NNS
cord-022353-q2k2krnm	1439	6	with	with	IN
cord-022353-q2k2krnm	1439	7	inactivation	inactivation	NN
cord-022353-q2k2krnm	1439	8	of	of	IN
cord-022353-q2k2krnm	1439	9	ABCA-1	ABCA-1	NNP
cord-022353-q2k2krnm	1439	10	in	in	IN
cord-022353-q2k2krnm	1439	11	microphages	microphages	NNP
cord-022353-q2k2krnm	1439	12	Diet	Diet	NNP
cord-022353-q2k2krnm	1439	13	-	-	HYPH
cord-022353-q2k2krnm	1439	14	induced	induce	VBN
cord-022353-q2k2krnm	1439	15	changes	change	NNS
cord-022353-q2k2krnm	1439	16	in	in	IN
cord-022353-q2k2krnm	1439	17	plasma	plasma	NN
cord-022353-q2k2krnm	1439	18	phospholipids	phospholipid	NNS
cord-022353-q2k2krnm	1439	19	transfer	transfer	NN
cord-022353-q2k2krnm	1439	20	protein	protein	NN
cord-022353-q2k2krnm	1439	21	activity	activity	NN
cord-022353-q2k2krnm	1439	22	,	,	,
cord-022353-q2k2krnm	1439	23	lipids	lipid	NNS
cord-022353-q2k2krnm	1439	24	,	,	,
cord-022353-q2k2krnm	1439	25	and	and	CC
cord-022353-q2k2krnm	1439	26	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	1439	27	.	.	.
cord-022353-q2k2krnm	1440	1	MPD	MPD	NNP
cord-022353-q2k2krnm	1440	2	:	:	:
cord-022353-q2k2krnm	1440	3	801	801	CD
cord-022353-q2k2krnm	1440	4	,	,	,
cord-022353-q2k2krnm	1440	5	802	802	CD
cord-022353-q2k2krnm	1440	6	,	,	,
cord-022353-q2k2krnm	1440	7	828	828	CD
cord-022353-q2k2krnm	1440	8	.	.	.
cord-022353-q2k2krnm	1441	1	Mouse	Mouse	NNP
cord-022353-q2k2krnm	1441	2	Phenome	Phenome	NNP
cord-022353-q2k2krnm	1441	3	Database	database	NN
cord-022353-q2k2krnm	1441	4	Web	web	NN
cord-022353-q2k2krnm	1441	5	Site	site	NN
cord-022353-q2k2krnm	1441	6	Comparison	comparison	NN
cord-022353-q2k2krnm	1441	7	of	of	IN
cord-022353-q2k2krnm	1441	8	magnesium	magnesium	NN
cord-022353-q2k2krnm	1441	9	deficiency	deficiency	NN
cord-022353-q2k2krnm	1441	10	in	in	IN
cord-022353-q2k2krnm	1441	11	the	the	DT
cord-022353-q2k2krnm	1441	12	rat	rat	NN
cord-022353-q2k2krnm	1441	13	and	and	CC
cord-022353-q2k2krnm	1441	14	mouse	mouse	VB
cord-022353-q2k2krnm	1441	15	ApoC-1	ApoC-1	NNP
cord-022353-q2k2krnm	1441	16	and	and	CC
cord-022353-q2k2krnm	1441	17	ApoC	ApoC	NNP
cord-022353-q2k2krnm	1441	18	-	-	HYPH
cord-022353-q2k2krnm	1441	19	III	III	NNP
cord-022353-q2k2krnm	1441	20	as	as	IN
cord-022353-q2k2krnm	1441	21	potential	potential	JJ
cord-022353-q2k2krnm	1441	22	plasmatic	plasmatic	JJ
cord-022353-q2k2krnm	1441	23	markers	marker	NNS
cord-022353-q2k2krnm	1441	24	to	to	TO
cord-022353-q2k2krnm	1441	25	distinguish	distinguish	VB
cord-022353-q2k2krnm	1441	26	between	between	IN
cord-022353-q2k2krnm	1441	27	ischemic	ischemic	JJ
cord-022353-q2k2krnm	1441	28	and	and	CC
cord-022353-q2k2krnm	1441	29	hemorrhagic	hemorrhagic	JJ
cord-022353-q2k2krnm	1441	30	stroke	stroke	NN
cord-022353-q2k2krnm	1441	31	Comparison	comparison	NN
cord-022353-q2k2krnm	1441	32	of	of	IN
cord-022353-q2k2krnm	1441	33	methods	method	NNS
cord-022353-q2k2krnm	1441	34	for	for	IN
cord-022353-q2k2krnm	1441	35	obtaining	obtain	VBG
cord-022353-q2k2krnm	1441	36	blood	blood	NN
cord-022353-q2k2krnm	1441	37	from	from	IN
cord-022353-q2k2krnm	1441	38	mice	mouse	NNS
cord-022353-q2k2krnm	1441	39	Anxiety	anxiety	NN
cord-022353-q2k2krnm	1441	40	and	and	CC
cord-022353-q2k2krnm	1441	41	stress	stress	NN
cord-022353-q2k2krnm	1441	42	responses	response	NNS
cord-022353-q2k2krnm	1441	43	in	in	IN
cord-022353-q2k2krnm	1441	44	female	female	JJ
cord-022353-q2k2krnm	1441	45	oxytocin	oxytocin	NNS
cord-022353-q2k2krnm	1442	1	deficient	deficient	JJ
cord-022353-q2k2krnm	1442	2	mice	mouse	NNS
cord-022353-q2k2krnm	1443	1	Impaired	impaired	JJ
cord-022353-q2k2krnm	1443	2	calcification	calcification	NN
cord-022353-q2k2krnm	1443	3	around	around	IN
cord-022353-q2k2krnm	1443	4	matrix	matrix	NN
cord-022353-q2k2krnm	1443	5	vesicles	vesicle	NNS
cord-022353-q2k2krnm	1443	6	of	of	IN
cord-022353-q2k2krnm	1443	7	growth	growth	NN
cord-022353-q2k2krnm	1443	8	plate	plate	NN
cord-022353-q2k2krnm	1443	9	and	and	CC
cord-022353-q2k2krnm	1443	10	bone	bone	NN
cord-022353-q2k2krnm	1443	11	in	in	IN
cord-022353-q2k2krnm	1443	12	alkaline	alkaline	JJ
cord-022353-q2k2krnm	1443	13	phosphatase	phosphatase	NN
cord-022353-q2k2krnm	1443	14	-	-	HYPH
cord-022353-q2k2krnm	1443	15	deficient	deficient	JJ
cord-022353-q2k2krnm	1443	16	mice	mouse	NNS
cord-022353-q2k2krnm	1443	17	Hormonal	hormonal	JJ
cord-022353-q2k2krnm	1443	18	control	control	NN
cord-022353-q2k2krnm	1443	19	of	of	IN
cord-022353-q2k2krnm	1443	20	Leydig	Leydig	NNP
cord-022353-q2k2krnm	1443	21	cell	cell	NN
cord-022353-q2k2krnm	1443	22	differentiation	differentiation	NN
cord-022353-q2k2krnm	1443	23	Interleukin-7	interleukin-7	IN
cord-022353-q2k2krnm	1443	24	an	an	DT
cord-022353-q2k2krnm	1443	25	interleukin	interleukin	NN
cord-022353-q2k2krnm	1443	26	for	for	IN
cord-022353-q2k2krnm	1443	27	rejuvenating	rejuvenate	VBG
cord-022353-q2k2krnm	1443	28	the	the	DT
cord-022353-q2k2krnm	1443	29	immune	immune	JJ
cord-022353-q2k2krnm	1443	30	system	system	NN
cord-022353-q2k2krnm	1444	1	A	a	DT
cord-022353-q2k2krnm	1444	2	spectrophotometric	spectrophotometric	JJ
cord-022353-q2k2krnm	1444	3	microtiter	microtiter	NN
cord-022353-q2k2krnm	1444	4	-	-	HYPH
cord-022353-q2k2krnm	1444	5	based	base	VBN
cord-022353-q2k2krnm	1444	6	assay	assay	NN
cord-022353-q2k2krnm	1444	7	for	for	IN
cord-022353-q2k2krnm	1444	8	the	the	DT
cord-022353-q2k2krnm	1444	9	detection	detection	NN
cord-022353-q2k2krnm	1444	10	of	of	IN
cord-022353-q2k2krnm	1444	11	hydroperoxy	hydroperoxy	JJ
cord-022353-q2k2krnm	1444	12	derivatives	derivative	NNS
cord-022353-q2k2krnm	1444	13	of	of	IN
cord-022353-q2k2krnm	1444	14	linoleic	linoleic	JJ
cord-022353-q2k2krnm	1444	15	acid	acid	NN
cord-022353-q2k2krnm	1444	16	Mast	Mast	NNP
cord-022353-q2k2krnm	1444	17	cell	cell	NN
cord-022353-q2k2krnm	1444	18	lineage	lineage	NN
cord-022353-q2k2krnm	1444	19	development	development	NN
cord-022353-q2k2krnm	1444	20	and	and	CC
cord-022353-q2k2krnm	1444	21	phenotypic	phenotypic	JJ
cord-022353-q2k2krnm	1444	22	regulation	regulation	NN
cord-022353-q2k2krnm	1444	23	Laboratory	Laboratory	NNP
cord-022353-q2k2krnm	1444	24	routines	routine	NNS
cord-022353-q2k2krnm	1444	25	cause	cause	VBP
cord-022353-q2k2krnm	1444	26	animal	animal	NN
cord-022353-q2k2krnm	1444	27	stress	stress	NN
cord-022353-q2k2krnm	1444	28	Regulation	regulation	NN
cord-022353-q2k2krnm	1444	29	of	of	IN
cord-022353-q2k2krnm	1444	30	fasting	fast	VBG
cord-022353-q2k2krnm	1444	31	blood	blood	NN
cord-022353-q2k2krnm	1444	32	glucose	glucose	NN
cord-022353-q2k2krnm	1444	33	by	by	IN
cord-022353-q2k2krnm	1444	34	resistin	resistin	NNS
cord-022353-q2k2krnm	1444	35	Biochemistry	Biochemistry	NNP
cord-022353-q2k2krnm	1444	36	of	of	IN
cord-022353-q2k2krnm	1444	37	Immunoglobulins	Immunoglobulins	NNP
cord-022353-q2k2krnm	1444	38	Variations	Variations	NNPS
cord-022353-q2k2krnm	1444	39	in	in	IN
cord-022353-q2k2krnm	1444	40	serum	serum	NN
cord-022353-q2k2krnm	1444	41	calcium	calcium	NN
cord-022353-q2k2krnm	1444	42	between	between	IN
cord-022353-q2k2krnm	1444	43	strains	strain	NNS
cord-022353-q2k2krnm	1444	44	of	of	IN
cord-022353-q2k2krnm	1444	45	inbred	inbred	JJ
cord-022353-q2k2krnm	1444	46	mice	mice	NN
cord-022353-q2k2krnm	1444	47	Correction	correction	NN
cord-022353-q2k2krnm	1444	48	of	of	IN
cord-022353-q2k2krnm	1444	49	ureagenesis	ureagenesis	NN
cord-022353-q2k2krnm	1444	50	after	after	IN
cord-022353-q2k2krnm	1444	51	gene	gene	NN
cord-022353-q2k2krnm	1444	52	transfer	transfer	NN
cord-022353-q2k2krnm	1444	53	in	in	IN
cord-022353-q2k2krnm	1444	54	an	an	DT
cord-022353-q2k2krnm	1444	55	animal	animal	NN
cord-022353-q2k2krnm	1444	56	model	model	NN
cord-022353-q2k2krnm	1444	57	and	and	CC
cord-022353-q2k2krnm	1444	58	after	after	IN
cord-022353-q2k2krnm	1444	59	liver	liver	NN
cord-022353-q2k2krnm	1444	60	transplantation	transplantation	NN
cord-022353-q2k2krnm	1444	61	in	in	IN
cord-022353-q2k2krnm	1444	62	humans	human	NNS
cord-022353-q2k2krnm	1444	63	with	with	IN
cord-022353-q2k2krnm	1444	64	ornithine	ornithine	NN
cord-022353-q2k2krnm	1444	65	transcarbamylase	transcarbamylase	NN
cord-022353-q2k2krnm	1444	66	deficiency	deficiency	NN
cord-022353-q2k2krnm	1444	67	Biology	biology	NN
cord-022353-q2k2krnm	1444	68	of	of	IN
cord-022353-q2k2krnm	1444	69	the	the	DT
cord-022353-q2k2krnm	1444	70	congenitally	congenitally	RB
cord-022353-q2k2krnm	1444	71	hypothyroid	hypothyroid	JJ
cord-022353-q2k2krnm	1444	72	hyt	hyt	NN
cord-022353-q2k2krnm	1444	73	/	/	SYM
cord-022353-q2k2krnm	1444	74	hyt	hyt	NNP
cord-022353-q2k2krnm	1444	75	mouse	mouse	NN
cord-022353-q2k2krnm	1445	1	The	the	DT
cord-022353-q2k2krnm	1445	2	chemokine	chemokine	NN
cord-022353-q2k2krnm	1445	3	stromal	stromal	JJ
cord-022353-q2k2krnm	1445	4	cell	cell	NN
cord-022353-q2k2krnm	1445	5	-	-	HYPH
cord-022353-q2k2krnm	1445	6	derived	derive	VBN
cord-022353-q2k2krnm	1445	7	factor-1	factor-1	NNP
cord-022353-q2k2krnm	1445	8	regulates	regulate	VBZ
cord-022353-q2k2krnm	1445	9	the	the	DT
cord-022353-q2k2krnm	1445	10	migration	migration	NN
cord-022353-q2k2krnm	1445	11	of	of	IN
cord-022353-q2k2krnm	1445	12	sensory	sensory	JJ
cord-022353-q2k2krnm	1445	13	neutron	neutron	NN
cord-022353-q2k2krnm	1445	14	progenitors	progenitor	NNS
cord-022353-q2k2krnm	1445	15	Methods	method	NNS
cord-022353-q2k2krnm	1445	16	of	of	IN
cord-022353-q2k2krnm	1445	17	enzymatic	enzymatic	JJ
cord-022353-q2k2krnm	1445	18	analysis	analysis	NN
cord-022353-q2k2krnm	1446	1	The	the	DT
cord-022353-q2k2krnm	1446	2	Mouse	Mouse	NNP
cord-022353-q2k2krnm	1446	3	Phenome	Phenome	NNP
cord-022353-q2k2krnm	1446	4	Project	Project	NNP
cord-022353-q2k2krnm	1446	5	Purification	Purification	NNP
cord-022353-q2k2krnm	1446	6	and	and	CC
cord-022353-q2k2krnm	1446	7	characterization	characterization	NN
cord-022353-q2k2krnm	1446	8	of	of	IN
cord-022353-q2k2krnm	1446	9	human	human	NN
cord-022353-q2k2krnm	1446	10	and	and	CC
cord-022353-q2k2krnm	1446	11	mouse	mouse	NN
cord-022353-q2k2krnm	1446	12	recombinant	recombinant	JJ
cord-022353-q2k2krnm	1446	13	alpha	alpha	NN
cord-022353-q2k2krnm	1446	14	-	-	HYPH
cord-022353-q2k2krnm	1446	15	fetoproteins	fetoproteins	NNP
cord-022353-q2k2krnm	1446	16	expressed	express	VBN
cord-022353-q2k2krnm	1446	17	in	in	IN
cord-022353-q2k2krnm	1446	18	Escherichia	Escherichia	NNP
cord-022353-q2k2krnm	1446	19	coli	coli	NNS
cord-022353-q2k2krnm	1446	20	Genetically	genetically	RB
cord-022353-q2k2krnm	1446	21	engineered	engineer	VBN
cord-022353-q2k2krnm	1446	22	animals	animal	NNS
cord-022353-q2k2krnm	1446	23	in	in	IN
cord-022353-q2k2krnm	1446	24	drug	drug	NN
cord-022353-q2k2krnm	1446	25	discovery	discovery	NN
cord-022353-q2k2krnm	1446	26	and	and	CC
cord-022353-q2k2krnm	1446	27	development	development	NN
cord-022353-q2k2krnm	1446	28	:	:	:
cord-022353-q2k2krnm	1446	29	a	a	DT
cord-022353-q2k2krnm	1446	30	maturing	mature	VBG
cord-022353-q2k2krnm	1446	31	resource	resource	NN
cord-022353-q2k2krnm	1446	32	for	for	IN
cord-022353-q2k2krnm	1446	33	toxicologic	toxicologic	NN
cord-022353-q2k2krnm	1446	34	research	research	NN
cord-022353-q2k2krnm	1446	35	Effects	effect	NNS
cord-022353-q2k2krnm	1446	36	of	of	IN
cord-022353-q2k2krnm	1446	37	heparin	heparin	NN
cord-022353-q2k2krnm	1446	38	on	on	IN
cord-022353-q2k2krnm	1446	39	serum	serum	NN
cord-022353-q2k2krnm	1446	40	calcium	calcium	NN
cord-022353-q2k2krnm	1446	41	in	in	IN
cord-022353-q2k2krnm	1446	42	mice	mouse	NNS
cord-022353-q2k2krnm	1446	43	Albumin	albumin	NN
cord-022353-q2k2krnm	1446	44	content	content	NN
cord-022353-q2k2krnm	1446	45	in	in	IN
cord-022353-q2k2krnm	1446	46	blood	blood	NN
cord-022353-q2k2krnm	1446	47	of	of	IN
cord-022353-q2k2krnm	1446	48	inbred	inbred	JJ
cord-022353-q2k2krnm	1446	49	mice	mice	NN
cord-022353-q2k2krnm	1446	50	strains	strain	NNS
cord-022353-q2k2krnm	1447	1	Lentiviral	Lentiviral	NNP
cord-022353-q2k2krnm	1447	2	shRNA	shrna	NN
cord-022353-q2k2krnm	1447	3	silencing	silencing	NN
cord-022353-q2k2krnm	1447	4	of	of	IN
cord-022353-q2k2krnm	1447	5	murine	murine	JJ
cord-022353-q2k2krnm	1447	6	bone	bone	NN
cord-022353-q2k2krnm	1447	7	marrow	marrow	NN
cord-022353-q2k2krnm	1447	8	cell	cell	NN
cord-022353-q2k2krnm	1447	9	CCR2	CCR2	NNP
cord-022353-q2k2krnm	1447	10	leads	lead	VBZ
cord-022353-q2k2krnm	1447	11	to	to	IN
cord-022353-q2k2krnm	1447	12	persistent	persistent	JJ
cord-022353-q2k2krnm	1447	13	knockdown	knockdown	NN
cord-022353-q2k2krnm	1447	14	of	of	IN
cord-022353-q2k2krnm	1447	15	CCR2	CCR2	NNP
cord-022353-q2k2krnm	1447	16	function	function	NN
cord-022353-q2k2krnm	1447	17	in	in	IN
cord-022353-q2k2krnm	1447	18	vivo	vivo	NNP
cord-022353-q2k2krnm	1447	19	Trophic	Trophic	NNP
cord-022353-q2k2krnm	1447	20	action	action	NN
cord-022353-q2k2krnm	1447	21	of	of	IN
cord-022353-q2k2krnm	1447	22	leptin	leptin	NN
cord-022353-q2k2krnm	1447	23	on	on	IN
cord-022353-q2k2krnm	1447	24	hypothalamic	hypothalamic	JJ
cord-022353-q2k2krnm	1447	25	neurons	neuron	NNS
cord-022353-q2k2krnm	1447	26	that	that	WDT
cord-022353-q2k2krnm	1447	27	regulate	regulate	VBP
cord-022353-q2k2krnm	1447	28	feeding	feed	VBG
cord-022353-q2k2krnm	1447	29	The	the	DT
cord-022353-q2k2krnm	1447	30	interpretation	interpretation	NN
cord-022353-q2k2krnm	1447	31	of	of	IN
cord-022353-q2k2krnm	1447	32	serum	serum	NN
cord-022353-q2k2krnm	1447	33	biochemistry	biochemistry	NN
cord-022353-q2k2krnm	1447	34	test	test	NN
cord-022353-q2k2krnm	1447	35	results	result	NNS
cord-022353-q2k2krnm	1447	36	in	in	IN
cord-022353-q2k2krnm	1447	37	domestic	domestic	JJ
cord-022353-q2k2krnm	1447	38	animals	animal	NNS
cord-022353-q2k2krnm	1447	39	Transgenic	transgenic	JJ
cord-022353-q2k2krnm	1447	40	models	model	NNS
cord-022353-q2k2krnm	1447	41	of	of	IN
cord-022353-q2k2krnm	1447	42	autoimmune	autoimmune	JJ
cord-022353-q2k2krnm	1447	43	disease	disease	NN
cord-022353-q2k2krnm	1447	44	Lipoprotein	Lipoprotein	NNP
cord-022353-q2k2krnm	1447	45	metabolism	metabolism	NN
cord-022353-q2k2krnm	1447	46	and	and	CC
cord-022353-q2k2krnm	1447	47	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1447	48	susceptibility	susceptibility	NN
cord-022353-q2k2krnm	1447	49	in	in	IN
cord-022353-q2k2krnm	1447	50	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1447	51	mic	mic	NN
cord-022353-q2k2krnm	1447	52	Mouse	mouse	NN
cord-022353-q2k2krnm	1447	53	models	model	NNS
cord-022353-q2k2krnm	1447	54	of	of	IN
cord-022353-q2k2krnm	1447	55	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1447	56	Reproductive	reproductive	JJ
cord-022353-q2k2krnm	1447	57	failure	failure	NN
cord-022353-q2k2krnm	1447	58	in	in	IN
cord-022353-q2k2krnm	1447	59	aged	aged	JJ
cord-022353-q2k2krnm	1447	60	CBF	CBF	NNP
cord-022353-q2k2krnm	1447	61	male	male	JJ
cord-022353-q2k2krnm	1447	62	mice	mouse	NNS
cord-022353-q2k2krnm	1447	63	:	:	:
cord-022353-q2k2krnm	1447	64	interrelationships	interrelationship	NNS
cord-022353-q2k2krnm	1447	65	between	between	IN
cord-022353-q2k2krnm	1447	66	pituitary	pituitary	JJ
cord-022353-q2k2krnm	1447	67	gonadotropic	gonadotropic	NNP
cord-022353-q2k2krnm	1447	68	hormones	hormone	NNS
cord-022353-q2k2krnm	1447	69	,	,	,
cord-022353-q2k2krnm	1447	70	testicular	testicular	JJ
cord-022353-q2k2krnm	1447	71	function	function	NN
cord-022353-q2k2krnm	1447	72	,	,	,
cord-022353-q2k2krnm	1447	73	and	and	CC
cord-022353-q2k2krnm	1447	74	mating	mate	VBG
cord-022353-q2k2krnm	1447	75	success	success	NN
cord-022353-q2k2krnm	1447	76	Stromal	Stromal	NNP
cord-022353-q2k2krnm	1447	77	cell	cell	NN
cord-022353-q2k2krnm	1447	78	derived	derive	VBD
cord-022353-q2k2krnm	1447	79	factor	factor	NN
cord-022353-q2k2krnm	1447	80	1	1	CD
cord-022353-q2k2krnm	1448	1	/CXCL12	/CXCL12	NFP
cord-022353-q2k2krnm	1448	2	selectively	selectively	RB
cord-022353-q2k2krnm	1448	3	counteracts	counteract	VBZ
cord-022353-q2k2krnm	1448	4	inhibitory	inhibitory	JJ
cord-022353-q2k2krnm	1448	5	effects	effect	NNS
cord-022353-q2k2krnm	1448	6	of	of	IN
cord-022353-q2k2krnm	1448	7	myelosuppressive	myelosuppressive	NNP
cord-022353-q2k2krnm	1448	8	chemokines	chemokine	NNS
cord-022353-q2k2krnm	1448	9	on	on	IN
cord-022353-q2k2krnm	1448	10	hematopoieteic	hematopoieteic	VBN
cord-022353-q2k2krnm	1448	11	progenitor	progenitor	NN
cord-022353-q2k2krnm	1448	12	cell	cell	NN
cord-022353-q2k2krnm	1448	13	proliferation	proliferation	NN
cord-022353-q2k2krnm	1448	14	in	in	IN
cord-022353-q2k2krnm	1448	15	vitro	vitro	FW
cord-022353-q2k2krnm	1448	16	Minireview	minireview	NN
cord-022353-q2k2krnm	1448	17	:	:	:
cord-022353-q2k2krnm	1448	18	genetic	genetic	JJ
cord-022353-q2k2krnm	1448	19	models	model	NNS
cord-022353-q2k2krnm	1448	20	for	for	IN
cord-022353-q2k2krnm	1448	21	the	the	DT
cord-022353-q2k2krnm	1448	22	study	study	NN
cord-022353-q2k2krnm	1448	23	of	of	IN
cord-022353-q2k2krnm	1448	24	gonadotropin	gonadotropin	JJ
cord-022353-q2k2krnm	1448	25	actions	action	NNS
cord-022353-q2k2krnm	1448	26	Recruitment	Recruitment	NNP
cord-022353-q2k2krnm	1448	27	of	of	IN
cord-022353-q2k2krnm	1448	28	CXCR3	CXCR3	NNP
cord-022353-q2k2krnm	1448	29	and	and	CC
cord-022353-q2k2krnm	1448	30	CCR5	CCR5	NNP
cord-022353-q2k2krnm	1448	31	T	T	NNP
cord-022353-q2k2krnm	1448	32	-	-	HYPH
cord-022353-q2k2krnm	1448	33	cells	cell	NNS
cord-022353-q2k2krnm	1448	34	and	and	CC
cord-022353-q2k2krnm	1448	35	production	production	NN
cord-022353-q2k2krnm	1448	36	of	of	IN
cord-022353-q2k2krnm	1448	37	interferon	interferon	NN
cord-022353-q2k2krnm	1448	38	-	-	HYPH
cord-022353-q2k2krnm	1448	39	gamma	gamma	NN
cord-022353-q2k2krnm	1448	40	inducible	inducible	JJ
cord-022353-q2k2krnm	1448	41	chemokines	chemokine	NNS
cord-022353-q2k2krnm	1448	42	in	in	IN
cord-022353-q2k2krnm	1448	43	rejecting	reject	VBG
cord-022353-q2k2krnm	1448	44	human	human	JJ
cord-022353-q2k2krnm	1448	45	arteries	artery	NNS
cord-022353-q2k2krnm	1449	1	Tietz	tietz	NN
cord-022353-q2k2krnm	1449	2	fundamentals	fundamental	NNS
cord-022353-q2k2krnm	1449	3	of	of	IN
cord-022353-q2k2krnm	1449	4	clinical	clinical	JJ
cord-022353-q2k2krnm	1449	5	chemistry	chemistry	NN
cord-022353-q2k2krnm	1449	6	Distribution	distribution	NN
cord-022353-q2k2krnm	1449	7	and	and	CC
cord-022353-q2k2krnm	1449	8	characterization	characterization	NN
cord-022353-q2k2krnm	1449	9	of	of	IN
cord-022353-q2k2krnm	1449	10	the	the	DT
cord-022353-q2k2krnm	1449	11	serum	serum	NN
cord-022353-q2k2krnm	1449	12	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	1449	13	and	and	CC
cord-022353-q2k2krnm	1449	14	apolipoproteins	apolipoprotein	NNS
cord-022353-q2k2krnm	1449	15	in	in	IN
cord-022353-q2k2krnm	1449	16	the	the	DT
cord-022353-q2k2krnm	1449	17	mouse	mouse	NN
cord-022353-q2k2krnm	1449	18	,	,	,
cord-022353-q2k2krnm	1449	19	Mus	Mus	NNP
cord-022353-q2k2krnm	1449	20	musculus	musculus	NN
cord-022353-q2k2krnm	1449	21	Disparate	disparate	JJ
cord-022353-q2k2krnm	1449	22	lymphoid	lymphoid	JJ
cord-022353-q2k2krnm	1449	23	chemokine	chemokine	NN
cord-022353-q2k2krnm	1449	24	expression	expression	NN
cord-022353-q2k2krnm	1449	25	in	in	IN
cord-022353-q2k2krnm	1449	26	mice	mouse	NNS
cord-022353-q2k2krnm	1449	27	and	and	CC
cord-022353-q2k2krnm	1449	28	men	man	NNS
cord-022353-q2k2krnm	1449	29	:	:	:
cord-022353-q2k2krnm	1449	30	no	no	DT
cord-022353-q2k2krnm	1449	31	evidence	evidence	NN
cord-022353-q2k2krnm	1449	32	for	for	IN
cord-022353-q2k2krnm	1449	33	CCL21	CCL21	NNP
cord-022353-q2k2krnm	1449	34	synthesis	synthesis	NN
cord-022353-q2k2krnm	1449	35	by	by	IN
cord-022353-q2k2krnm	1449	36	human	human	JJ
cord-022353-q2k2krnm	1449	37	high	high	JJ
cord-022353-q2k2krnm	1449	38	endothelial	endothelial	JJ
cord-022353-q2k2krnm	1449	39	venules	venule	VBZ
cord-022353-q2k2krnm	1449	40	Insulin	insulin	IN
cord-022353-q2k2krnm	1449	41	secretion	secretion	NN
cord-022353-q2k2krnm	1449	42	profiles	profile	NNS
cord-022353-q2k2krnm	1449	43	are	be	VBP
cord-022353-q2k2krnm	1449	44	modified	modify	VBN
cord-022353-q2k2krnm	1449	45	by	by	IN
cord-022353-q2k2krnm	1449	46	over	over	IN
cord-022353-q2k2krnm	1449	47	expression	expression	NN
cord-022353-q2k2krnm	1449	48	of	of	IN
cord-022353-q2k2krnm	1449	49	glutamate	glutamate	NN
cord-022353-q2k2krnm	1449	50	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	1449	51	in	in	IN
cord-022353-q2k2krnm	1449	52	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	1449	53	islets	islet	NNS
cord-022353-q2k2krnm	1450	1	A	a	DT
cord-022353-q2k2krnm	1450	2	panel	panel	NN
cord-022353-q2k2krnm	1450	3	of	of	IN
cord-022353-q2k2krnm	1450	4	cerebrospinal	cerebrospinal	JJ
cord-022353-q2k2krnm	1450	5	fluid	fluid	JJ
cord-022353-q2k2krnm	1450	6	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	1450	7	for	for	IN
cord-022353-q2k2krnm	1450	8	the	the	DT
cord-022353-q2k2krnm	1450	9	diagnosis	diagnosis	NN
cord-022353-q2k2krnm	1450	10	of	of	IN
cord-022353-q2k2krnm	1450	11	Alzheimer	Alzheimer	NNP
cord-022353-q2k2krnm	1450	12	's	's	POS
cord-022353-q2k2krnm	1450	13	disease	disease	NN
cord-022353-q2k2krnm	1451	1	Normal	normal	JJ
cord-022353-q2k2krnm	1451	2	,	,	,
cord-022353-q2k2krnm	1451	3	benign	benign	JJ
cord-022353-q2k2krnm	1451	4	,	,	,
cord-022353-q2k2krnm	1451	5	preneoplastic	preneoplastic	JJ
cord-022353-q2k2krnm	1451	6	,	,	,
cord-022353-q2k2krnm	1451	7	and	and	CC
cord-022353-q2k2krnm	1451	8	malignant	malignant	JJ
cord-022353-q2k2krnm	1451	9	prostate	prostate	NN
cord-022353-q2k2krnm	1451	10	cells	cell	NNS
cord-022353-q2k2krnm	1451	11	have	have	VBP
cord-022353-q2k2krnm	1451	12	distinct	distinct	JJ
cord-022353-q2k2krnm	1451	13	protein	protein	NN
cord-022353-q2k2krnm	1451	14	expression	expression	NN
cord-022353-q2k2krnm	1451	15	profiles	profile	NNS
cord-022353-q2k2krnm	1451	16	resolved	resolve	VBN
cord-022353-q2k2krnm	1451	17	by	by	IN
cord-022353-q2k2krnm	1451	18	surface	surface	NN
cord-022353-q2k2krnm	1451	19	enhanced	enhance	VBN
cord-022353-q2k2krnm	1451	20	laser	laser	NN
cord-022353-q2k2krnm	1451	21	desorption	desorption	NN
cord-022353-q2k2krnm	1451	22	/	/	SYM
cord-022353-q2k2krnm	1451	23	ionization	ionization	NN
cord-022353-q2k2krnm	1451	24	mass	mass	NN
cord-022353-q2k2krnm	1451	25	spectrometry	spectrometry	NN
cord-022353-q2k2krnm	1451	26	Chemokine	Chemokine	NNP
cord-022353-q2k2krnm	1451	27	-	-	HYPH
cord-022353-q2k2krnm	1451	28	cytokine	cytokine	NN
cord-022353-q2k2krnm	1451	29	cross	cross	NN
cord-022353-q2k2krnm	1451	30	talk	talk	NN
cord-022353-q2k2krnm	1451	31	.	.	.
cord-022353-q2k2krnm	1452	1	The	the	DT
cord-022353-q2k2krnm	1452	2	ELRt	ELRt	NNPS
cord-022353-q2k2krnm	1452	3	cxc	cxc	NNP
cord-022353-q2k2krnm	1452	4	chemokine	chemokine	NN
cord-022353-q2k2krnm	1452	5	LIX	LIX	NNP
cord-022353-q2k2krnm	1452	6	(	(	-LRB-
cord-022353-q2k2krnm	1452	7	CXCLS	CXCLS	NNP
cord-022353-q2k2krnm	1452	8	)	)	-RRB-
cord-022353-q2k2krnm	1452	9	amplifies	amplify	VBZ
cord-022353-q2k2krnm	1452	10	a	a	DT
cord-022353-q2k2krnm	1452	11	proinflammatory	proinflammatory	JJ
cord-022353-q2k2krnm	1452	12	cytokine	cytokine	NN
cord-022353-q2k2krnm	1452	13	response	response	NN
cord-022353-q2k2krnm	1452	14	via	via	IN
cord-022353-q2k2krnm	1452	15	a	a	DT
cord-022353-q2k2krnm	1452	16	phosphatedy	phosphatedy	NNP
cord-022353-q2k2krnm	1452	17	linositol	linositol	NNP
cord-022353-q2k2krnm	1452	18	3-kinase	3-kinase	CD
cord-022353-q2k2krnm	1452	19	-	-	HYPH
cord-022353-q2k2krnm	1452	20	NF	nf	NN
cord-022353-q2k2krnm	1452	21	-	-	HYPH
cord-022353-q2k2krnm	1452	22	kappa	kappa	NN
cord-022353-q2k2krnm	1452	23	B	B	NNP
cord-022353-q2k2krnm	1452	24	pathway	pathway	NN
cord-022353-q2k2krnm	1452	25	Rapid	Rapid	NNP
cord-022353-q2k2krnm	1452	26	neurosecretory	neurosecretory	NN
cord-022353-q2k2krnm	1452	27	and	and	CC
cord-022353-q2k2krnm	1452	28	cardiovascular	cardiovascular	JJ
cord-022353-q2k2krnm	1452	29	response	response	NN
cord-022353-q2k2krnm	1452	30	to	to	IN
cord-022353-q2k2krnm	1452	31	osmotic	osmotic	JJ
cord-022353-q2k2krnm	1452	32	stimulation	stimulation	NN
cord-022353-q2k2krnm	1452	33	in	in	IN
cord-022353-q2k2krnm	1452	34	conscious	conscious	JJ
cord-022353-q2k2krnm	1452	35	mice	mouse	NNS
cord-022353-q2k2krnm	1452	36	High	high	JJ
cord-022353-q2k2krnm	1452	37	density	density	NN
cord-022353-q2k2krnm	1452	38	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	1452	39	retard	retard	VBP
cord-022353-q2k2krnm	1452	40	the	the	DT
cord-022353-q2k2krnm	1452	41	progression	progression	NN
cord-022353-q2k2krnm	1452	42	of	of	IN
cord-022353-q2k2krnm	1452	43	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1452	44	and	and	CC
cord-022353-q2k2krnm	1452	45	favorably	favorably	RB
cord-022353-q2k2krnm	1452	46	remodel	remodel	VB
cord-022353-q2k2krnm	1452	47	lesions	lesion	NNS
cord-022353-q2k2krnm	1452	48	without	without	IN
cord-022353-q2k2krnm	1452	49	suppressing	suppress	VBG
cord-022353-q2k2krnm	1452	50	indices	index	NNS
cord-022353-q2k2krnm	1452	51	of	of	IN
cord-022353-q2k2krnm	1452	52	inflammation	inflammation	NN
cord-022353-q2k2krnm	1452	53	or	or	CC
cord-022353-q2k2krnm	1452	54	oxidation	oxidation	NN
cord-022353-q2k2krnm	1452	55	Influence	influence	NN
cord-022353-q2k2krnm	1452	56	of	of	IN
cord-022353-q2k2krnm	1452	57	blood	blood	NN
cord-022353-q2k2krnm	1452	58	collection	collection	NN
cord-022353-q2k2krnm	1452	59	sites	site	NNS
cord-022353-q2k2krnm	1452	60	and	and	CC
cord-022353-q2k2krnm	1452	61	use	use	NN
cord-022353-q2k2krnm	1452	62	of	of	IN
cord-022353-q2k2krnm	1452	63	anesthesia	anesthesia	NN
cord-022353-q2k2krnm	1452	64	on	on	IN
cord-022353-q2k2krnm	1452	65	plasma	plasma	NN
cord-022353-q2k2krnm	1452	66	glucose	glucose	NN
cord-022353-q2k2krnm	1452	67	concentration	concentration	NN
cord-022353-q2k2krnm	1452	68	in	in	IN
cord-022353-q2k2krnm	1452	69	mice	mouse	NNS
cord-022353-q2k2krnm	1453	1	The	the	DT
cord-022353-q2k2krnm	1453	2	tissue	tissue	NN
cord-022353-q2k2krnm	1453	3	activities	activity	NNS
cord-022353-q2k2krnm	1453	4	of	of	IN
cord-022353-q2k2krnm	1453	5	some	some	DT
cord-022353-q2k2krnm	1453	6	diagnostic	diagnostic	JJ
cord-022353-q2k2krnm	1453	7	enzymes	enzyme	NNS
cord-022353-q2k2krnm	1453	8	in	in	IN
cord-022353-q2k2krnm	1453	9	ten	ten	CD
cord-022353-q2k2krnm	1453	10	mammalian	mammalian	JJ
cord-022353-q2k2krnm	1453	11	species	specie	NNS
cord-022353-q2k2krnm	1453	12	Accelerated	accelerate	VBD
cord-022353-q2k2krnm	1453	13	intestinal	intestinal	JJ
cord-022353-q2k2krnm	1453	14	epithelial	epithelial	JJ
cord-022353-q2k2krnm	1453	15	cell	cell	NN
cord-022353-q2k2krnm	1453	16	turnover	turnover	NN
cord-022353-q2k2krnm	1453	17	:	:	:
cord-022353-q2k2krnm	1453	18	a	a	DT
cord-022353-q2k2krnm	1453	19	new	new	JJ
cord-022353-q2k2krnm	1453	20	mechanism	mechanism	NN
cord-022353-q2k2krnm	1453	21	of	of	IN
cord-022353-q2k2krnm	1453	22	parasite	parasite	JJ
cord-022353-q2k2krnm	1453	23	expulsion	expulsion	NN
cord-022353-q2k2krnm	1453	24	Signal	Signal	NNP
cord-022353-q2k2krnm	1453	25	transduction	transduction	NN
cord-022353-q2k2krnm	1453	26	in	in	IN
cord-022353-q2k2krnm	1453	27	T	T	NNP
cord-022353-q2k2krnm	1453	28	cells	cell	NNS
cord-022353-q2k2krnm	1453	29	:	:	:
cord-022353-q2k2krnm	1453	30	an	an	DT
cord-022353-q2k2krnm	1453	31	overview	overview	NN
cord-022353-q2k2krnm	1453	32	Role	role	NN
cord-022353-q2k2krnm	1453	33	of	of	IN
cord-022353-q2k2krnm	1453	34	stearoyl	stearoyl	NNP
cord-022353-q2k2krnm	1453	35	-	-	HYPH
cord-022353-q2k2krnm	1453	36	CoA	CoA	NNP
cord-022353-q2k2krnm	1453	37	desaturase-1	desaturase-1	NNP
cord-022353-q2k2krnm	1453	38	in	in	IN
cord-022353-q2k2krnm	1453	39	leptinmediated	leptinmediated	JJ
cord-022353-q2k2krnm	1453	40	weight	weight	NN
cord-022353-q2k2krnm	1453	41	loss	loss	NN
cord-022353-q2k2krnm	1453	42	Induction	Induction	NNP
cord-022353-q2k2krnm	1453	43	of	of	IN
cord-022353-q2k2krnm	1453	44	leptin	leptin	NN
cord-022353-q2k2krnm	1453	45	receptor	receptor	NN
cord-022353-q2k2krnm	1453	46	expression	expression	NN
cord-022353-q2k2krnm	1453	47	in	in	IN
cord-022353-q2k2krnm	1453	48	the	the	DT
cord-022353-q2k2krnm	1453	49	liver	liver	NN
cord-022353-q2k2krnm	1453	50	by	by	IN
cord-022353-q2k2krnm	1453	51	leptin	leptin	NN
cord-022353-q2k2krnm	1453	52	and	and	CC
cord-022353-q2k2krnm	1453	53	food	food	NN
cord-022353-q2k2krnm	1453	54	deprivation	deprivation	NN
cord-022353-q2k2krnm	1453	55	Mouse	mouse	NN
cord-022353-q2k2krnm	1453	56	models	model	NNS
cord-022353-q2k2krnm	1453	57	of	of	IN
cord-022353-q2k2krnm	1453	58	male	male	JJ
cord-022353-q2k2krnm	1453	59	infertility	infertility	NN
cord-022353-q2k2krnm	1454	1	The	the	DT
cord-022353-q2k2krnm	1454	2	primary	primary	JJ
cord-022353-q2k2krnm	1454	3	germinal	germinal	JJ
cord-022353-q2k2krnm	1454	4	center	center	NN
cord-022353-q2k2krnm	1454	5	response	response	NN
cord-022353-q2k2krnm	1454	6	in	in	IN
cord-022353-q2k2krnm	1454	7	mice	mouse	NNS
cord-022353-q2k2krnm	1455	1	A	a	DT
cord-022353-q2k2krnm	1455	2	comparison	comparison	NN
cord-022353-q2k2krnm	1455	3	of	of	IN
cord-022353-q2k2krnm	1455	4	serum	serum	NN
cord-022353-q2k2krnm	1455	5	calcium	calcium	NN
cord-022353-q2k2krnm	1455	6	levels	level	NNS
cord-022353-q2k2krnm	1455	7	obtained	obtain	VBN
cord-022353-q2k2krnm	1455	8	by	by	IN
cord-022353-q2k2krnm	1455	9	two	two	CD
cord-022353-q2k2krnm	1455	10	methods	method	NNS
cord-022353-q2k2krnm	1455	11	of	of	IN
cord-022353-q2k2krnm	1455	12	cardiac	cardiac	JJ
cord-022353-q2k2krnm	1455	13	puncture	puncture	NN
cord-022353-q2k2krnm	1455	14	in	in	IN
cord-022353-q2k2krnm	1455	15	mice	mouse	NNS
cord-022353-q2k2krnm	1455	16	Biomethodology	Biomethodology	NNP
cord-022353-q2k2krnm	1455	17	and	and	CC
cord-022353-q2k2krnm	1455	18	surgical	surgical	JJ
cord-022353-q2k2krnm	1455	19	techniques	technique	NNS
cord-022353-q2k2krnm	1455	20	Reduction	reduction	NN
cord-022353-q2k2krnm	1455	21	in	in	IN
cord-022353-q2k2krnm	1455	22	the	the	DT
cord-022353-q2k2krnm	1455	23	development	development	NN
cord-022353-q2k2krnm	1455	24	of	of	IN
cord-022353-q2k2krnm	1455	25	cerulean	cerulean	NN
cord-022353-q2k2krnm	1455	26	-	-	HYPH
cord-022353-q2k2krnm	1455	27	induced	induce	VBN
cord-022353-q2k2krnm	1455	28	acute	acute	JJ
cord-022353-q2k2krnm	1455	29	pancreatitis	pancreatitis	NN
cord-022353-q2k2krnm	1455	30	by	by	IN
cord-022353-q2k2krnm	1455	31	treatment	treatment	NN
cord-022353-q2k2krnm	1455	32	with	with	IN
cord-022353-q2k2krnm	1455	33	M40401	M40401	NNP
cord-022353-q2k2krnm	1455	34	,	,	,
cord-022353-q2k2krnm	1455	35	a	a	DT
cord-022353-q2k2krnm	1455	36	new	new	JJ
cord-022353-q2k2krnm	1455	37	selective	selective	JJ
cord-022353-q2k2krnm	1455	38	superoxide	superoxide	NN
cord-022353-q2k2krnm	1455	39	dismutase	dismutase	NN
cord-022353-q2k2krnm	1455	40	mimetic	mimetic	NN
cord-022353-q2k2krnm	1455	41	Pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	1455	42	lipase	lipase	NN
cord-022353-q2k2krnm	1455	43	-	-	HYPH
cord-022353-q2k2krnm	1455	44	related	relate	VBN
cord-022353-q2k2krnm	1455	45	protein	protein	NN
cord-022353-q2k2krnm	1455	46	2	2	CD
cord-022353-q2k2krnm	1455	47	is	be	VBZ
cord-022353-q2k2krnm	1455	48	the	the	DT
cord-022353-q2k2krnm	1455	49	major	major	JJ
cord-022353-q2k2krnm	1455	50	colipase	colipase	NN
cord-022353-q2k2krnm	1455	51	-	-	HYPH
cord-022353-q2k2krnm	1455	52	dependent	dependent	JJ
cord-022353-q2k2krnm	1455	53	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	1455	54	lipase	lipase	NN
cord-022353-q2k2krnm	1455	55	in	in	IN
cord-022353-q2k2krnm	1455	56	suckling	suckle	VBG
cord-022353-q2k2krnm	1455	57	mice	mouse	NNS
cord-022353-q2k2krnm	1455	58	Effects	effect	NNS
cord-022353-q2k2krnm	1455	59	of	of	IN
cord-022353-q2k2krnm	1455	60	cannabinoids	cannabinoid	NNS
cord-022353-q2k2krnm	1455	61	and	and	CC
cord-022353-q2k2krnm	1455	62	female	female	JJ
cord-022353-q2k2krnm	1455	63	exposure	exposure	NN
cord-022353-q2k2krnm	1455	64	on	on	IN
cord-022353-q2k2krnm	1455	65	the	the	DT
cord-022353-q2k2krnm	1455	66	pituitary	pituitary	NN
cord-022353-q2k2krnm	1455	67	testicular	testicular	NN
cord-022353-q2k2krnm	1455	68	axis	axis	NN
cord-022353-q2k2krnm	1455	69	in	in	IN
cord-022353-q2k2krnm	1455	70	mice	mouse	NNS
cord-022353-q2k2krnm	1455	71	:	:	:
cord-022353-q2k2krnm	1455	72	possible	possible	JJ
cord-022353-q2k2krnm	1455	73	involvement	involvement	NN
cord-022353-q2k2krnm	1455	74	of	of	IN
cord-022353-q2k2krnm	1455	75	prostaglandins	prostaglandin	NNS
cord-022353-q2k2krnm	1455	76	Genetic	genetic	JJ
cord-022353-q2k2krnm	1455	77	background	background	NN
cord-022353-q2k2krnm	1455	78	determines	determine	VBZ
cord-022353-q2k2krnm	1455	79	the	the	DT
cord-022353-q2k2krnm	1455	80	extent	extent	NN
cord-022353-q2k2krnm	1455	81	of	of	IN
cord-022353-q2k2krnm	1455	82	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1455	83	in	in	IN
cord-022353-q2k2krnm	1455	84	ApoE	ApoE	NNS
cord-022353-q2k2krnm	1455	85	-	-	HYPH
cord-022353-q2k2krnm	1455	86	deficient	deficient	JJ
cord-022353-q2k2krnm	1455	87	mice	mouse	NNS
cord-022353-q2k2krnm	1455	88	Endocrine	endocrine	JJ
cord-022353-q2k2krnm	1455	89	hormones	hormone	NNS
cord-022353-q2k2krnm	1455	90	in	in	IN
cord-022353-q2k2krnm	1455	91	laboratory	laboratory	NN
cord-022353-q2k2krnm	1455	92	animals	animal	NNS
cord-022353-q2k2krnm	1455	93	Antibody	Antibody	NNP
cord-022353-q2k2krnm	1455	94	interference	interference	NN
cord-022353-q2k2krnm	1455	95	in	in	IN
cord-022353-q2k2krnm	1455	96	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1455	97	assays	assay	NNS
cord-022353-q2k2krnm	1455	98	:	:	:
cord-022353-q2k2krnm	1455	99	a	a	DT
cord-022353-q2k2krnm	1455	100	potential	potential	NN
cord-022353-q2k2krnm	1455	101	for	for	IN
cord-022353-q2k2krnm	1455	102	clinical	clinical	JJ
cord-022353-q2k2krnm	1455	103	misinformation	misinformation	NN
cord-022353-q2k2krnm	1456	1	A	a	DT
cord-022353-q2k2krnm	1456	2	new	new	JJ
cord-022353-q2k2krnm	1456	3	kinetic	kinetic	JJ
cord-022353-q2k2krnm	1456	4	determination	determination	NN
cord-022353-q2k2krnm	1456	5	of	of	IN
cord-022353-q2k2krnm	1456	6	serum	serum	NN
cord-022353-q2k2krnm	1456	7	5'-nucleotidase	5'-nucleotidase	CD
cord-022353-q2k2krnm	1456	8	activity	activity	NN
cord-022353-q2k2krnm	1456	9	,	,	,
cord-022353-q2k2krnm	1456	10	with	with	IN
cord-022353-q2k2krnm	1456	11	modifications	modification	NNS
cord-022353-q2k2krnm	1456	12	for	for	IN
cord-022353-q2k2krnm	1456	13	a	a	DT
cord-022353-q2k2krnm	1456	14	centrifugal	centrifugal	JJ
cord-022353-q2k2krnm	1456	15	analyzer	analyzer	NN
cord-022353-q2k2krnm	1457	1	The	the	DT
cord-022353-q2k2krnm	1457	2	roles	role	NNS
cord-022353-q2k2krnm	1457	3	of	of	IN
cord-022353-q2k2krnm	1457	4	prolactin	prolactin	NN
cord-022353-q2k2krnm	1457	5	,	,	,
cord-022353-q2k2krnm	1457	6	growth	growth	NN
cord-022353-q2k2krnm	1457	7	hormone	hormone	NN
cord-022353-q2k2krnm	1457	8	,	,	,
cord-022353-q2k2krnm	1457	9	insulin	insulin	NN
cord-022353-q2k2krnm	1457	10	-	-	HYPH
cord-022353-q2k2krnm	1457	11	like	like	JJ
cord-022353-q2k2krnm	1457	12	growth	growth	NN
cord-022353-q2k2krnm	1457	13	factor	factor	NN
cord-022353-q2k2krnm	1457	14	-	-	HYPH
cord-022353-q2k2krnm	1457	15	l	l	NN
cord-022353-q2k2krnm	1457	16	,	,	,
cord-022353-q2k2krnm	1457	17	and	and	CC
cord-022353-q2k2krnm	1457	18	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1457	19	hormones	hormone	NNS
cord-022353-q2k2krnm	1457	20	in	in	IN
cord-022353-q2k2krnm	1457	21	lymphocyte	lymphocyte	NN
cord-022353-q2k2krnm	1457	22	development	development	NN
cord-022353-q2k2krnm	1457	23	and	and	CC
cord-022353-q2k2krnm	1457	24	function	function	NN
cord-022353-q2k2krnm	1457	25	;	;	:
cord-022353-q2k2krnm	1457	26	insights	insight	NNS
cord-022353-q2k2krnm	1457	27	from	from	IN
cord-022353-q2k2krnm	1457	28	genetic	genetic	JJ
cord-022353-q2k2krnm	1457	29	models	model	NNS
cord-022353-q2k2krnm	1457	30	of	of	IN
cord-022353-q2k2krnm	1457	31	hormone	hormone	NN
cord-022353-q2k2krnm	1457	32	and	and	CC
cord-022353-q2k2krnm	1457	33	hormone	hormone	NN
cord-022353-q2k2krnm	1457	34	receptor	receptor	NN
cord-022353-q2k2krnm	1457	35	deficiency	deficiency	NN
cord-022353-q2k2krnm	1457	36	Selection	Selection	NNP
cord-022353-q2k2krnm	1457	37	for	for	IN
cord-022353-q2k2krnm	1457	38	serum	serum	NN
cord-022353-q2k2krnm	1457	39	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1457	40	,	,	,
cord-022353-q2k2krnm	1457	41	voluntary	voluntary	JJ
cord-022353-q2k2krnm	1457	42	physical	physical	JJ
cord-022353-q2k2krnm	1457	43	activity	activity	NN
cord-022353-q2k2krnm	1457	44	,	,	,
cord-022353-q2k2krnm	1457	45	56-day	56-day	CD
cord-022353-q2k2krnm	1457	46	body	body	NN
cord-022353-q2k2krnm	1457	47	weight	weight	NN
cord-022353-q2k2krnm	1457	48	,	,	,
cord-022353-q2k2krnm	1457	49	and	and	CC
cord-022353-q2k2krnm	1457	50	feed	feed	VB
cord-022353-q2k2krnm	1457	51	intake	intake	NN
cord-022353-q2k2krnm	1457	52	in	in	IN
cord-022353-q2k2krnm	1457	53	random	random	JJ
cord-022353-q2k2krnm	1457	54	bred	bred	JJ
cord-022353-q2k2krnm	1457	55	mice	mouse	NNS
cord-022353-q2k2krnm	1457	56	.	.	.
cord-022353-q2k2krnm	1458	1	II	II	NNP
cord-022353-q2k2krnm	1458	2	.	.	.
cord-022353-q2k2krnm	1459	1	Correlated	correlate	VBN
cord-022353-q2k2krnm	1459	2	response	response	NN
cord-022353-q2k2krnm	1459	3	CCR2	CCR2	NNP
cord-022353-q2k2krnm	1459	4	expression	expression	NN
cord-022353-q2k2krnm	1459	5	by	by	IN
cord-022353-q2k2krnm	1459	6	brain	brain	NN
cord-022353-q2k2krnm	1459	7	microvascular	microvascular	JJ
cord-022353-q2k2krnm	1459	8	endothelial	endothelial	JJ
cord-022353-q2k2krnm	1459	9	cells	cell	NNS
cord-022353-q2k2krnm	1459	10	critical	critical	JJ
cord-022353-q2k2krnm	1459	11	for	for	IN
cord-022353-q2k2krnm	1459	12	macrophage	macrophage	NN
cord-022353-q2k2krnm	1459	13	transendothelial	transendothelial	JJ
cord-022353-q2k2krnm	1459	14	migration	migration	NN
cord-022353-q2k2krnm	1459	15	in	in	IN
cord-022353-q2k2krnm	1459	16	response	response	NN
cord-022353-q2k2krnm	1459	17	to	to	IN
cord-022353-q2k2krnm	1459	18	CCL2	CCL2	NNP
cord-022353-q2k2krnm	1459	19	Inhibition	Inhibition	NNP
cord-022353-q2k2krnm	1459	20	of	of	IN
cord-022353-q2k2krnm	1459	21	apolipoprotein	apolipoprotein	NN
cord-022353-q2k2krnm	1459	22	B	b	NN
cord-022353-q2k2krnm	1459	23	secretion	secretion	NN
cord-022353-q2k2krnm	1459	24	by	by	IN
cord-022353-q2k2krnm	1459	25	taurocholate	taurocholate	NNP
cord-022353-q2k2krnm	1459	26	is	be	VBZ
cord-022353-q2k2krnm	1459	27	controlled	control	VBN
cord-022353-q2k2krnm	1459	28	by	by	IN
cord-022353-q2k2krnm	1459	29	N	n	CD
cord-022353-q2k2krnm	1459	30	-	-	HYPH
cord-022353-q2k2krnm	1459	31	terminal	terminal	JJ
cord-022353-q2k2krnm	1459	32	end	end	NN
cord-022353-q2k2krnm	1459	33	of	of	IN
cord-022353-q2k2krnm	1459	34	the	the	DT
cord-022353-q2k2krnm	1459	35	protein	protein	NN
cord-022353-q2k2krnm	1459	36	in	in	IN
cord-022353-q2k2krnm	1459	37	rat	rat	NN
cord-022353-q2k2krnm	1459	38	hepatoma	hepatoma	NNP
cord-022353-q2k2krnm	1459	39	McArdle	McArdle	NNP
cord-022353-q2k2krnm	1459	40	-	-	:
cord-022353-q2k2krnm	1459	41	RH7777	rh7777	NN
cord-022353-q2k2krnm	1459	42	Cells	cell	NNS
cord-022353-q2k2krnm	1459	43	Clinical	clinical	JJ
cord-022353-q2k2krnm	1459	44	biochemistry	biochemistry	NN
cord-022353-q2k2krnm	1460	1	The	the	DT
cord-022353-q2k2krnm	1460	2	effect	effect	NN
cord-022353-q2k2krnm	1460	3	of	of	IN
cord-022353-q2k2krnm	1460	4	freezing	freeze	VBG
cord-022353-q2k2krnm	1460	5	on	on	IN
cord-022353-q2k2krnm	1460	6	various	various	JJ
cord-022353-q2k2krnm	1460	7	serum	serum	NN
cord-022353-q2k2krnm	1460	8	chemistry	chemistry	NN
cord-022353-q2k2krnm	1460	9	parameters	parameter	NNS
cord-022353-q2k2krnm	1460	10	of	of	IN
cord-022353-q2k2krnm	1460	11	common	common	JJ
cord-022353-q2k2krnm	1460	12	laboratory	laboratory	NN
cord-022353-q2k2krnm	1460	13	animals	animal	NNS
cord-022353-q2k2krnm	1460	14	Alkaline	alkaline	JJ
cord-022353-q2k2krnm	1460	15	phosphatase	phosphatase	NN
cord-022353-q2k2krnm	1460	16	,	,	,
cord-022353-q2k2krnm	1460	17	lactate	lactate	NN
cord-022353-q2k2krnm	1460	18	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	1460	19	,	,	,
cord-022353-q2k2krnm	1460	20	and	and	CC
cord-022353-q2k2krnm	1460	21	aspartate	aspartate	NN
cord-022353-q2k2krnm	1460	22	aminotransferase	aminotransferase	NN
cord-022353-q2k2krnm	1460	23	and	and	CC
cord-022353-q2k2krnm	1460	24	their	-PRON-	PRP$
cord-022353-q2k2krnm	1460	25	isoenzymes	isoenzyme	NNS
cord-022353-q2k2krnm	1460	26	as	as	IN
cord-022353-q2k2krnm	1460	27	indicators	indicator	NNS
cord-022353-q2k2krnm	1460	28	of	of	IN
cord-022353-q2k2krnm	1460	29	the	the	DT
cord-022353-q2k2krnm	1460	30	development	development	NN
cord-022353-q2k2krnm	1460	31	of	of	IN
cord-022353-q2k2krnm	1460	32	experimental	experimental	JJ
cord-022353-q2k2krnm	1460	33	hepatitis	hepatitis	NN
cord-022353-q2k2krnm	1460	34	in	in	IN
cord-022353-q2k2krnm	1460	35	mic	mic	NNP
cord-022353-q2k2krnm	1461	1	The	the	DT
cord-022353-q2k2krnm	1461	2	endoplasmic	endoplasmic	NN
cord-022353-q2k2krnm	1461	3	reticulum	reticulum	NN
cord-022353-q2k2krnm	1461	4	is	be	VBZ
cord-022353-q2k2krnm	1461	5	the	the	DT
cord-022353-q2k2krnm	1461	6	site	site	NN
cord-022353-q2k2krnm	1461	7	of	of	IN
cord-022353-q2k2krnm	1461	8	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1461	9	-	-	HYPH
cord-022353-q2k2krnm	1461	10	induced	induce	VBN
cord-022353-q2k2krnm	1461	11	cytotoxicity	cytotoxicity	NN
cord-022353-q2k2krnm	1461	12	in	in	IN
cord-022353-q2k2krnm	1461	13	macrophages	macrophage	NNS
cord-022353-q2k2krnm	1461	14	Niemann	Niemann	NNP
cord-022353-q2k2krnm	1461	15	-	-	HYPH
cord-022353-q2k2krnm	1461	16	Pick	Pick	NNP
cord-022353-q2k2krnm	1461	17	C	c	NN
cord-022353-q2k2krnm	1461	18	heterozygosity	heterozygosity	NN
cord-022353-q2k2krnm	1461	19	confers	confer	VBZ
cord-022353-q2k2krnm	1461	20	resistance	resistance	NN
cord-022353-q2k2krnm	1461	21	to	to	IN
cord-022353-q2k2krnm	1461	22	lesional	lesional	JJ
cord-022353-q2k2krnm	1461	23	necrosis	necrosis	NN
cord-022353-q2k2krnm	1461	24	and	and	CC
cord-022353-q2k2krnm	1461	25	macrophage	macrophage	NN
cord-022353-q2k2krnm	1461	26	apoptosis	apoptosis	NN
cord-022353-q2k2krnm	1461	27	in	in	IN
cord-022353-q2k2krnm	1461	28	murine	murine	JJ
cord-022353-q2k2krnm	1461	29	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1462	1	Hematologic	Hematologic	NNP
cord-022353-q2k2krnm	1462	2	and	and	CC
cord-022353-q2k2krnm	1462	3	serum	serum	NN
cord-022353-q2k2krnm	1462	4	electrolyte	electrolyte	JJ
cord-022353-q2k2krnm	1462	5	values	value	NNS
cord-022353-q2k2krnm	1462	6	of	of	IN
cord-022353-q2k2krnm	1462	7	the	the	DT
cord-022353-q2k2krnm	1462	8	C57BL/6J	C57BL/6J	NNP
cord-022353-q2k2krnm	1462	9	male	male	JJ
cord-022353-q2k2krnm	1462	10	mouse	mouse	NN
cord-022353-q2k2krnm	1462	11	in	in	IN
cord-022353-q2k2krnm	1462	12	maturity	maturity	NN
cord-022353-q2k2krnm	1462	13	and	and	CC
cord-022353-q2k2krnm	1462	14	senescence	senescence	NN
cord-022353-q2k2krnm	1462	15	Hormone	hormone	NN
cord-022353-q2k2krnm	1462	16	production	production	NN
cord-022353-q2k2krnm	1462	17	by	by	IN
cord-022353-q2k2krnm	1462	18	the	the	DT
cord-022353-q2k2krnm	1462	19	pituitary	pituitary	NN
cord-022353-q2k2krnm	1462	20	and	and	CC
cord-022353-q2k2krnm	1462	21	testes	testis	NNS
cord-022353-q2k2krnm	1462	22	of	of	IN
cord-022353-q2k2krnm	1462	23	male	male	JJ
cord-022353-q2k2krnm	1462	24	C57BL/6J	C57BL/6J	NNP
cord-022353-q2k2krnm	1462	25	mice	mouse	NNS
cord-022353-q2k2krnm	1462	26	during	during	IN
cord-022353-q2k2krnm	1462	27	aging	age	VBG
cord-022353-q2k2krnm	1462	28	Age	age	NN
cord-022353-q2k2krnm	1462	29	effects	effect	NNS
cord-022353-q2k2krnm	1462	30	of	of	IN
cord-022353-q2k2krnm	1462	31	luteinizing	luteinize	VBG
cord-022353-q2k2krnm	1462	32	hormone	hormone	NN
cord-022353-q2k2krnm	1462	33	,	,	,
cord-022353-q2k2krnm	1462	34	progesterone	progesterone	NN
cord-022353-q2k2krnm	1462	35	,	,	,
cord-022353-q2k2krnm	1462	36	and	and	CC
cord-022353-q2k2krnm	1462	37	prolactin	prolactin	NN
cord-022353-q2k2krnm	1462	38	in	in	IN
cord-022353-q2k2krnm	1462	39	proestrus	proestrus	NNP
cord-022353-q2k2krnm	1462	40	and	and	CC
cord-022353-q2k2krnm	1462	41	acyclic	acyclic	JJ
cord-022353-q2k2krnm	1462	42	C57BL/6J	C57BL/6J	NNP
cord-022353-q2k2krnm	1462	43	mice	mouse	NNS
cord-022353-q2k2krnm	1463	1	Innovation	innovation	NN
cord-022353-q2k2krnm	1463	2	~	~	NFP
cord-022353-q2k2krnm	1463	3	stagnation	stagnation	NN
cord-022353-q2k2krnm	1463	4	:	:	:
cord-022353-q2k2krnm	1463	5	challenge	challenge	NN
cord-022353-q2k2krnm	1463	6	and	and	CC
cord-022353-q2k2krnm	1463	7	opportunity	opportunity	NN
cord-022353-q2k2krnm	1463	8	on	on	IN
cord-022353-q2k2krnm	1463	9	the	the	DT
cord-022353-q2k2krnm	1463	10	critical	critical	JJ
cord-022353-q2k2krnm	1463	11	path	path	NN
cord-022353-q2k2krnm	1463	12	to	to	IN
cord-022353-q2k2krnm	1463	13	new	new	JJ
cord-022353-q2k2krnm	1463	14	medical	medical	JJ
cord-022353-q2k2krnm	1463	15	products	product	NNS
cord-022353-q2k2krnm	1464	1	Interleukin-17	interleukin-17	IN
cord-022353-q2k2krnm	1464	2	Hematologic	Hematologic	NNP
cord-022353-q2k2krnm	1464	3	and	and	CC
cord-022353-q2k2krnm	1464	4	clinical	clinical	JJ
cord-022353-q2k2krnm	1464	5	chemistry	chemistry	NN
cord-022353-q2k2krnm	1464	6	findings	finding	NNS
cord-022353-q2k2krnm	1464	7	in	in	IN
cord-022353-q2k2krnm	1464	8	control	control	NN
cord-022353-q2k2krnm	1464	9	BALB	BALB	NNP
cord-022353-q2k2krnm	1464	10	/	/	SYM
cord-022353-q2k2krnm	1464	11	c	c	NN
cord-022353-q2k2krnm	1464	12	and	and	CC
cord-022353-q2k2krnm	1464	13	C57BL/6	C57BL/6	NNP
cord-022353-q2k2krnm	1464	14	mice	mouse	NNS
cord-022353-q2k2krnm	1464	15	PI3	pi3	NN
cord-022353-q2k2krnm	1464	16	K	K	NNP
cord-022353-q2k2krnm	1464	17	and	and	CC
cord-022353-q2k2krnm	1464	18	negative	negative	JJ
cord-022353-q2k2krnm	1464	19	regulation	regulation	NN
cord-022353-q2k2krnm	1464	20	of	of	IN
cord-022353-q2k2krnm	1464	21	TLR	TLR	NNP
cord-022353-q2k2krnm	1464	22	signaling	signal	VBG
cord-022353-q2k2krnm	1464	23	Visfatin	Visfatin	NNP
cord-022353-q2k2krnm	1464	24	:	:	:
cord-022353-q2k2krnm	1465	1	A	a	DT
cord-022353-q2k2krnm	1465	2	protein	protein	NN
cord-022353-q2k2krnm	1465	3	secreted	secrete	VBN
cord-022353-q2k2krnm	1465	4	by	by	IN
cord-022353-q2k2krnm	1465	5	visceral	visceral	JJ
cord-022353-q2k2krnm	1465	6	fat	fat	NN
cord-022353-q2k2krnm	1465	7	that	that	WDT
cord-022353-q2k2krnm	1465	8	mimics	mimic	VBZ
cord-022353-q2k2krnm	1465	9	the	the	DT
cord-022353-q2k2krnm	1465	10	effects	effect	NNS
cord-022353-q2k2krnm	1465	11	of	of	IN
cord-022353-q2k2krnm	1465	12	insulin	insulin	NN
cord-022353-q2k2krnm	1465	13	Floor	Floor	NNP
cord-022353-q2k2krnm	1465	14	space	space	NN
cord-022353-q2k2krnm	1465	15	needs	need	NNS
cord-022353-q2k2krnm	1465	16	for	for	IN
cord-022353-q2k2krnm	1465	17	laboratory	laboratory	NN
cord-022353-q2k2krnm	1465	18	mice	mouse	NNS
cord-022353-q2k2krnm	1465	19	:	:	:
cord-022353-q2k2krnm	1465	20	C57BL/6males	c57bl/6male	NNS
cord-022353-q2k2krnm	1465	21	in	in	IN
cord-022353-q2k2krnm	1465	22	solid	solid	JJ
cord-022353-q2k2krnm	1465	23	-	-	HYPH
cord-022353-q2k2krnm	1465	24	bottom	bottom	NN
cord-022353-q2k2krnm	1465	25	cages	cage	NNS
cord-022353-q2k2krnm	1465	26	with	with	IN
cord-022353-q2k2krnm	1465	27	bedding	bed	VBG
cord-022353-q2k2krnm	1465	28	A	a	DT
cord-022353-q2k2krnm	1465	29	longitudinal	longitudinal	JJ
cord-022353-q2k2krnm	1465	30	hormonal	hormonal	JJ
cord-022353-q2k2krnm	1465	31	profile	profile	NN
cord-022353-q2k2krnm	1465	32	of	of	IN
cord-022353-q2k2krnm	1465	33	the	the	DT
cord-022353-q2k2krnm	1465	34	genetically	genetically	RB
cord-022353-q2k2krnm	1465	35	obese	obese	JJ
cord-022353-q2k2krnm	1465	36	mouse	mouse	NN
cord-022353-q2k2krnm	1465	37	Return	Return	NNP
cord-022353-q2k2krnm	1465	38	to	to	IN
cord-022353-q2k2krnm	1465	39	normal	normal	JJ
cord-022353-q2k2krnm	1465	40	of	of	IN
cord-022353-q2k2krnm	1465	41	blood	blood	NN
cord-022353-q2k2krnm	1465	42	-	-	HYPH
cord-022353-q2k2krnm	1465	43	glucose	glucose	NN
cord-022353-q2k2krnm	1465	44	,	,	,
cord-022353-q2k2krnm	1465	45	plasma	plasma	NN
cord-022353-q2k2krnm	1465	46	insulin	insulin	NN
cord-022353-q2k2krnm	1465	47	,	,	,
cord-022353-q2k2krnm	1465	48	and	and	CC
cord-022353-q2k2krnm	1465	49	weight	weight	NN
cord-022353-q2k2krnm	1465	50	gain	gain	NN
cord-022353-q2k2krnm	1465	51	in	in	IN
cord-022353-q2k2krnm	1465	52	New	New	NNP
cord-022353-q2k2krnm	1465	53	Zealand	Zealand	NNP
cord-022353-q2k2krnm	1465	54	obese	obese	JJ
cord-022353-q2k2krnm	1465	55	mice	mouse	NNS
cord-022353-q2k2krnm	1465	56	after	after	IN
cord-022353-q2k2krnm	1465	57	implantation	implantation	NN
cord-022353-q2k2krnm	1465	58	of	of	IN
cord-022353-q2k2krnm	1465	59	islets	islet	NNS
cord-022353-q2k2krnm	1465	60	of	of	IN
cord-022353-q2k2krnm	1465	61	Langerhans	Langerhans	NNP
cord-022353-q2k2krnm	1465	62	Acute	Acute	NNP
cord-022353-q2k2krnm	1465	63	phase	phase	NN
cord-022353-q2k2krnm	1465	64	proteins	protein	VBZ
cord-022353-q2k2krnm	1465	65	Ghrelin	Ghrelin	NNP
cord-022353-q2k2krnm	1465	66	:	:	:
cord-022353-q2k2krnm	1465	67	more	more	JJR
cord-022353-q2k2krnm	1465	68	than	than	IN
cord-022353-q2k2krnm	1465	69	a	a	DT
cord-022353-q2k2krnm	1465	70	new	new	JJ
cord-022353-q2k2krnm	1465	71	frontier	frontier	NN
cord-022353-q2k2krnm	1465	72	in	in	IN
cord-022353-q2k2krnm	1465	73	neuroendocrinology	neuroendocrinology	NN
cord-022353-q2k2krnm	1465	74	Tumor	Tumor	NNP
cord-022353-q2k2krnm	1465	75	necrosis	necrosis	NN
cord-022353-q2k2krnm	1465	76	factors	factor	NNS
cord-022353-q2k2krnm	1466	1	A	a	DT
cord-022353-q2k2krnm	1466	2	rapid	rapid	JJ
cord-022353-q2k2krnm	1466	3	,	,	,
cord-022353-q2k2krnm	1466	4	simple	simple	JJ
cord-022353-q2k2krnm	1466	5	,	,	,
cord-022353-q2k2krnm	1466	6	and	and	CC
cord-022353-q2k2krnm	1466	7	humane	humane	JJ
cord-022353-q2k2krnm	1466	8	method	method	NN
cord-022353-q2k2krnm	1466	9	for	for	IN
cord-022353-q2k2krnm	1466	10	submandibular	submandibular	JJ
cord-022353-q2k2krnm	1466	11	bleeding	bleeding	NN
cord-022353-q2k2krnm	1466	12	of	of	IN
cord-022353-q2k2krnm	1466	13	mice	mouse	NNS
cord-022353-q2k2krnm	1466	14	using	use	VBG
cord-022353-q2k2krnm	1466	15	a	a	DT
cord-022353-q2k2krnm	1466	16	lancet	lancet	NN
cord-022353-q2k2krnm	1466	17	Palatal	Palatal	NNP
cord-022353-q2k2krnm	1466	18	cytosol	cytosol	NN
cord-022353-q2k2krnm	1466	19	cortisol	cortisol	NN
cord-022353-q2k2krnm	1466	20	-	-	HYPH
cord-022353-q2k2krnm	1466	21	binding	bind	VBG
cord-022353-q2k2krnm	1466	22	protein	protein	NN
cord-022353-q2k2krnm	1466	23	associated	associate	VBN
cord-022353-q2k2krnm	1466	24	with	with	IN
cord-022353-q2k2krnm	1466	25	cleft	cleft	JJ
cord-022353-q2k2krnm	1466	26	palate	palate	NN
cord-022353-q2k2krnm	1466	27	susceptibility	susceptibility	NN
cord-022353-q2k2krnm	1466	28	and	and	CC
cord-022353-q2k2krnm	1466	29	H-2	h-2	NN
cord-022353-q2k2krnm	1466	30	genotype	genotype	NN
cord-022353-q2k2krnm	1466	31	Relationship	relationship	NN
cord-022353-q2k2krnm	1466	32	in	in	IN
cord-022353-q2k2krnm	1466	33	the	the	DT
cord-022353-q2k2krnm	1466	34	functional	functional	JJ
cord-022353-q2k2krnm	1466	35	levels	level	NNS
cord-022353-q2k2krnm	1466	36	of	of	IN
cord-022353-q2k2krnm	1466	37	early	early	JJ
cord-022353-q2k2krnm	1466	38	components	component	NNS
cord-022353-q2k2krnm	1466	39	of	of	IN
cord-022353-q2k2krnm	1466	40	complement	complement	NN
cord-022353-q2k2krnm	1466	41	to	to	IN
cord-022353-q2k2krnm	1466	42	the	the	DT
cord-022353-q2k2krnm	1466	43	H-2	H-2	NNP
cord-022353-q2k2krnm	1466	44	complex	complex	NN
cord-022353-q2k2krnm	1466	45	of	of	IN
cord-022353-q2k2krnm	1466	46	mice	mouse	NNS
cord-022353-q2k2krnm	1466	47	Developmental	developmental	JJ
cord-022353-q2k2krnm	1466	48	and	and	CC
cord-022353-q2k2krnm	1466	49	tissue	tissue	NN
cord-022353-q2k2krnm	1466	50	-	-	HYPH
cord-022353-q2k2krnm	1466	51	specific	specific	JJ
cord-022353-q2k2krnm	1466	52	regulation	regulation	NN
cord-022353-q2k2krnm	1466	53	of	of	IN
cord-022353-q2k2krnm	1466	54	parathyroid	parathyroid	JJ
cord-022353-q2k2krnm	1466	55	hormone	hormone	NN
cord-022353-q2k2krnm	1466	56	(	(	-LRB-
cord-022353-q2k2krnm	1466	57	PTH)/PTH	pth)/pth	NN
cord-022353-q2k2krnm	1466	58	-	-	HYPH
cord-022353-q2k2krnm	1466	59	related	relate	VBN
cord-022353-q2k2krnm	1466	60	peptide	peptide	NN
cord-022353-q2k2krnm	1466	61	receptor	receptor	NN
cord-022353-q2k2krnm	1466	62	gene	gene	NN
cord-022353-q2k2krnm	1466	63	expression	expression	NN
cord-022353-q2k2krnm	1466	64	CCL1-CCR8	CCL1-CCR8	NNP
cord-022353-q2k2krnm	1466	65	interactions	interaction	NNS
cord-022353-q2k2krnm	1466	66	:	:	:
cord-022353-q2k2krnm	1466	67	an	an	DT
cord-022353-q2k2krnm	1466	68	axis	axis	NN
cord-022353-q2k2krnm	1466	69	mediating	mediate	VBG
cord-022353-q2k2krnm	1466	70	the	the	DT
cord-022353-q2k2krnm	1466	71	recruitment	recruitment	NN
cord-022353-q2k2krnm	1466	72	of	of	IN
cord-022353-q2k2krnm	1466	73	T	T	NNP
cord-022353-q2k2krnm	1466	74	-	-	HYPH
cord-022353-q2k2krnm	1466	75	cells	cell	NNS
cord-022353-q2k2krnm	1466	76	and	and	CC
cord-022353-q2k2krnm	1466	77	Langerhans	Langerhans	NNP
cord-022353-q2k2krnm	1466	78	-	-	HYPH
cord-022353-q2k2krnm	1466	79	type	type	NN
cord-022353-q2k2krnm	1466	80	dendritic	dendritic	JJ
cord-022353-q2k2krnm	1466	81	cells	cell	NNS
cord-022353-q2k2krnm	1466	82	to	to	IN
cord-022353-q2k2krnm	1466	83	sites	site	NNS
cord-022353-q2k2krnm	1466	84	of	of	IN
cord-022353-q2k2krnm	1466	85	atopic	atopic	JJ
cord-022353-q2k2krnm	1466	86	skin	skin	NN
cord-022353-q2k2krnm	1466	87	inflammation	inflammation	NN
cord-022353-q2k2krnm	1466	88	Measurement	Measurement	NNP
cord-022353-q2k2krnm	1466	89	of	of	IN
cord-022353-q2k2krnm	1466	90	glycosylated	glycosylated	JJ
cord-022353-q2k2krnm	1466	91	haemoglobins	haemoglobin	NNS
cord-022353-q2k2krnm	1466	92	and	and	CC
cord-022353-q2k2krnm	1466	93	glycosylated	glycosylated	JJ
cord-022353-q2k2krnm	1466	94	plasma	plasma	NN
cord-022353-q2k2krnm	1466	95	proteins	protein	NNS
cord-022353-q2k2krnm	1466	96	in	in	IN
cord-022353-q2k2krnm	1466	97	animal	animal	NN
cord-022353-q2k2krnm	1466	98	models	model	NNS
cord-022353-q2k2krnm	1466	99	with	with	IN
cord-022353-q2k2krnm	1466	100	diabetes	diabete	NNS
cord-022353-q2k2krnm	1466	101	or	or	CC
cord-022353-q2k2krnm	1466	102	inappropriate	inappropriate	JJ
cord-022353-q2k2krnm	1466	103	hypoglycaemia	hypoglycaemia	NN
cord-022353-q2k2krnm	1466	104	Effects	effect	NNS
cord-022353-q2k2krnm	1466	105	of	of	IN
cord-022353-q2k2krnm	1466	106	humoral	humoral	JJ
cord-022353-q2k2krnm	1466	107	hypercalcemia	hypercalcemia	NN
cord-022353-q2k2krnm	1466	108	of	of	IN
cord-022353-q2k2krnm	1466	109	malignancy	malignancy	NN
cord-022353-q2k2krnm	1466	110	on	on	IN
cord-022353-q2k2krnm	1466	111	the	the	DT
cord-022353-q2k2krnm	1466	112	parathyroid	parathyroid	JJ
cord-022353-q2k2krnm	1466	113	gland	gland	NN
cord-022353-q2k2krnm	1466	114	in	in	IN
cord-022353-q2k2krnm	1466	115	nude	nude	JJ
cord-022353-q2k2krnm	1466	116	mice	mouse	NNS
cord-022353-q2k2krnm	1467	1	The	the	DT
cord-022353-q2k2krnm	1467	2	complex	complex	JJ
cord-022353-q2k2krnm	1467	3	role	role	NN
cord-022353-q2k2krnm	1467	4	of	of	IN
cord-022353-q2k2krnm	1467	5	Interlukin-10	interlukin-10	NN
cord-022353-q2k2krnm	1467	6	in	in	IN
cord-022353-q2k2krnm	1467	7	autoimmunity	autoimmunity	NN
cord-022353-q2k2krnm	1467	8	Tumor	tumor	NN
cord-022353-q2k2krnm	1467	9	necrosis	necrosis	NN
cord-022353-q2k2krnm	1467	10	factor	factor	NN
cord-022353-q2k2krnm	1467	11	ligand	ligand	NN
cord-022353-q2k2krnm	1467	12	superfamily	superfamily	NN
cord-022353-q2k2krnm	1467	13	:	:	:
cord-022353-q2k2krnm	1467	14	involvement	involvement	NN
cord-022353-q2k2krnm	1467	15	in	in	IN
cord-022353-q2k2krnm	1467	16	the	the	DT
cord-022353-q2k2krnm	1467	17	pathology	pathology	NN
cord-022353-q2k2krnm	1467	18	of	of	IN
cord-022353-q2k2krnm	1467	19	malignant	malignant	JJ
cord-022353-q2k2krnm	1467	20	lymphomas	lymphoma	NNS
cord-022353-q2k2krnm	1467	21	Caloric	caloric	JJ
cord-022353-q2k2krnm	1467	22	restriction	restriction	NN
cord-022353-q2k2krnm	1467	23	increases	increase	NNS
cord-022353-q2k2krnm	1468	1	gluconeogenic	gluconeogenic	NNP
cord-022353-q2k2krnm	1468	2	and	and	CC
cord-022353-q2k2krnm	1468	3	transaminase	transaminase	FW
cord-022353-q2k2krnm	1468	4	enzyme	enzyme	NN
cord-022353-q2k2krnm	1468	5	activities	activity	NNS
cord-022353-q2k2krnm	1468	6	in	in	IN
cord-022353-q2k2krnm	1468	7	mouse	mouse	NN
cord-022353-q2k2krnm	1468	8	liver	liver	NN
cord-022353-q2k2krnm	1468	9	Fructose	fructose	NN
cord-022353-q2k2krnm	1468	10	metabolizing	metabolize	VBG
cord-022353-q2k2krnm	1468	11	enzymes	enzyme	NNS
cord-022353-q2k2krnm	1468	12	from	from	IN
cord-022353-q2k2krnm	1468	13	mouse	mouse	NN
cord-022353-q2k2krnm	1468	14	livers	liver	NNS
cord-022353-q2k2krnm	1468	15	influence	influence	NN
cord-022353-q2k2krnm	1468	16	of	of	IN
cord-022353-q2k2krnm	1468	17	age	age	NN
cord-022353-q2k2krnm	1468	18	and	and	CC
cord-022353-q2k2krnm	1468	19	caloric	caloric	JJ
cord-022353-q2k2krnm	1468	20	restriction	restriction	NN
cord-022353-q2k2krnm	1468	21	Genetic	genetic	JJ
cord-022353-q2k2krnm	1468	22	ablation	ablation	NN
cord-022353-q2k2krnm	1468	23	of	of	IN
cord-022353-q2k2krnm	1468	24	orexin	orexin	NN
cord-022353-q2k2krnm	1468	25	neurons	neuron	NNS
cord-022353-q2k2krnm	1468	26	in	in	IN
cord-022353-q2k2krnm	1468	27	mice	mouse	NNS
cord-022353-q2k2krnm	1468	28	result	result	VBP
cord-022353-q2k2krnm	1468	29	in	in	IN
cord-022353-q2k2krnm	1468	30	narcolepsy	narcolepsy	NN
cord-022353-q2k2krnm	1468	31	,	,	,
cord-022353-q2k2krnm	1468	32	hypophagia	hypophagia	NNP
cord-022353-q2k2krnm	1468	33	,	,	,
cord-022353-q2k2krnm	1468	34	and	and	CC
cord-022353-q2k2krnm	1468	35	obesity	obesity	NN
cord-022353-q2k2krnm	1468	36	Prolactin	prolactin	NN
cord-022353-q2k2krnm	1468	37	and	and	CC
cord-022353-q2k2krnm	1468	38	the	the	DT
cord-022353-q2k2krnm	1468	39	prolactin	prolactin	NN
cord-022353-q2k2krnm	1468	40	receptor	receptor	NN
cord-022353-q2k2krnm	1468	41	:	:	:
cord-022353-q2k2krnm	1468	42	new	new	JJ
cord-022353-q2k2krnm	1468	43	targets	target	NNS
cord-022353-q2k2krnm	1468	44	of	of	IN
cord-022353-q2k2krnm	1468	45	an	an	DT
cord-022353-q2k2krnm	1468	46	old	old	JJ
cord-022353-q2k2krnm	1468	47	hormone	hormone	NN
cord-022353-q2k2krnm	1468	48	Optimal	Optimal	NNP
cord-022353-q2k2krnm	1468	49	conditions	condition	NNS
cord-022353-q2k2krnm	1468	50	for	for	IN
cord-022353-q2k2krnm	1468	51	the	the	DT
cord-022353-q2k2krnm	1468	52	determination	determination	NN
cord-022353-q2k2krnm	1468	53	of	of	IN
cord-022353-q2k2krnm	1468	54	serum	serum	NN
cord-022353-q2k2krnm	1468	55	alkaline	alkaline	JJ
cord-022353-q2k2krnm	1468	56	phosphatase	phosphatase	NN
cord-022353-q2k2krnm	1468	57	by	by	IN
cord-022353-q2k2krnm	1468	58	a	a	DT
cord-022353-q2k2krnm	1468	59	new	new	JJ
cord-022353-q2k2krnm	1468	60	kinetic	kinetic	JJ
cord-022353-q2k2krnm	1468	61	method	method	NN
cord-022353-q2k2krnm	1468	62	Blood	blood	NN
cord-022353-q2k2krnm	1468	63	collection	collection	NN
cord-022353-q2k2krnm	1468	64	in	in	IN
cord-022353-q2k2krnm	1468	65	mice	mouse	NNS
cord-022353-q2k2krnm	1468	66	using	use	VBG
cord-022353-q2k2krnm	1468	67	the	the	DT
cord-022353-q2k2krnm	1468	68	saphenous	saphenous	JJ
cord-022353-q2k2krnm	1468	69	vein	vein	NN
cord-022353-q2k2krnm	1468	70	:	:	:
cord-022353-q2k2krnm	1468	71	an	an	DT
cord-022353-q2k2krnm	1468	72	alternative	alternative	NN
cord-022353-q2k2krnm	1468	73	to	to	IN
cord-022353-q2k2krnm	1468	74	retroorbital	retroorbital	NNP
cord-022353-q2k2krnm	1468	75	collection	collection	NNP
cord-022353-q2k2krnm	1468	76	Transgenic	Transgenic	NNP
cord-022353-q2k2krnm	1468	77	analysis	analysis	NN
cord-022353-q2k2krnm	1468	78	of	of	IN
cord-022353-q2k2krnm	1468	79	drug	drug	NN
cord-022353-q2k2krnm	1468	80	-	-	HYPH
cord-022353-q2k2krnm	1468	81	metabolizing	metabolize	VBG
cord-022353-q2k2krnm	1468	82	enzymes	enzyme	NNS
cord-022353-q2k2krnm	1468	83	:	:	:
cord-022353-q2k2krnm	1468	84	pre	pre	JJ
cord-022353-q2k2krnm	1468	85	-	-	JJ
cord-022353-q2k2krnm	1468	86	clinical	clinical	JJ
cord-022353-q2k2krnm	1468	87	drug	drug	NN
cord-022353-q2k2krnm	1468	88	development	development	NN
cord-022353-q2k2krnm	1468	89	and	and	CC
cord-022353-q2k2krnm	1468	90	toxicology	toxicology	NN
cord-022353-q2k2krnm	1469	1	The	the	DT
cord-022353-q2k2krnm	1469	2	distribution	distribution	NN
cord-022353-q2k2krnm	1469	3	of	of	IN
cord-022353-q2k2krnm	1469	4	aspartate	aspartate	NN
cord-022353-q2k2krnm	1469	5	aminotransferases	aminotransferase	NNS
cord-022353-q2k2krnm	1469	6	in	in	IN
cord-022353-q2k2krnm	1469	7	normal	normal	JJ
cord-022353-q2k2krnm	1469	8	and	and	CC
cord-022353-q2k2krnm	1469	9	neoplastic	neoplastic	JJ
cord-022353-q2k2krnm	1469	10	rat	rat	NN
cord-022353-q2k2krnm	1469	11	and	and	CC
cord-022353-q2k2krnm	1469	12	mouse	mouse	NN
cord-022353-q2k2krnm	1469	13	tissues	tissue	NNS
cord-022353-q2k2krnm	1469	14	Hepatic	hepatic	JJ
cord-022353-q2k2krnm	1469	15	canalicular	canalicular	JJ
cord-022353-q2k2krnm	1469	16	membrane	membrane	NN
cord-022353-q2k2krnm	1469	17	transport	transport	NN
cord-022353-q2k2krnm	1469	18	of	of	IN
cord-022353-q2k2krnm	1469	19	bile	bile	NN
cord-022353-q2k2krnm	1469	20	salt	salt	NN
cord-022353-q2k2krnm	1469	21	in	in	IN
cord-022353-q2k2krnm	1469	22	C57L	c57l	NN
cord-022353-q2k2krnm	1469	23	/	/	SYM
cord-022353-q2k2krnm	1469	24	J	J	NNP
cord-022353-q2k2krnm	1469	25	and	and	CC
cord-022353-q2k2krnm	1469	26	AKR	AKR	NNP
cord-022353-q2k2krnm	1469	27	/	/	SYM
cord-022353-q2k2krnm	1469	28	J	J	NNP
cord-022353-q2k2krnm	1469	29	mice	mouse	NNS
cord-022353-q2k2krnm	1469	30	:	:	:
cord-022353-q2k2krnm	1469	31	Implications	implication	NNS
cord-022353-q2k2krnm	1469	32	for	for	IN
cord-022353-q2k2krnm	1469	33	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1469	34	gallstone	gallstone	NN
cord-022353-q2k2krnm	1469	35	formation	formation	NN
cord-022353-q2k2krnm	1469	36	Prolonged	prolong	VBN
cord-022353-q2k2krnm	1469	37	gestation	gestation	NN
cord-022353-q2k2krnm	1469	38	,	,	,
cord-022353-q2k2krnm	1469	39	elevated	elevated	JJ
cord-022353-q2k2krnm	1469	40	preparturitional	preparturitional	JJ
cord-022353-q2k2krnm	1469	41	plasma	plasma	NN
cord-022353-q2k2krnm	1469	42	progesterone	progesterone	NN
cord-022353-q2k2krnm	1469	43	,	,	,
cord-022353-q2k2krnm	1469	44	and	and	CC
cord-022353-q2k2krnm	1469	45	reproductive	reproductive	JJ
cord-022353-q2k2krnm	1469	46	aging	age	VBG
cord-022353-q2k2krnm	1469	47	in	in	IN
cord-022353-q2k2krnm	1469	48	C57BL/6J	C57BL/6J	NNP
cord-022353-q2k2krnm	1469	49	mice	mouse	NNS
cord-022353-q2k2krnm	1470	1	Mild	mild	JJ
cord-022353-q2k2krnm	1470	2	dyslipidemia	dyslipidemia	NN
cord-022353-q2k2krnm	1470	3	in	in	IN
cord-022353-q2k2krnm	1470	4	mice	mouse	NNS
cord-022353-q2k2krnm	1470	5	following	follow	VBG
cord-022353-q2k2krnm	1470	6	targeted	target	VBN
cord-022353-q2k2krnm	1470	7	inactivation	inactivation	NN
cord-022353-q2k2krnm	1470	8	of	of	IN
cord-022353-q2k2krnm	1470	9	the	the	DT
cord-022353-q2k2krnm	1470	10	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1470	11	lipase	lipase	NN
cord-022353-q2k2krnm	1470	12	gene	gene	NN
cord-022353-q2k2krnm	1470	13	Immunolocalization	Immunolocalization	NNP
cord-022353-q2k2krnm	1470	14	of	of	IN
cord-022353-q2k2krnm	1470	15	tissue	tissue	NN
cord-022353-q2k2krnm	1470	16	non	non	JJ
cord-022353-q2k2krnm	1470	17	-	-	JJ
cord-022353-q2k2krnm	1470	18	specific	specific	JJ
cord-022353-q2k2krnm	1470	19	alkaline	alkaline	JJ
cord-022353-q2k2krnm	1470	20	phosphatase	phosphatase	NN
cord-022353-q2k2krnm	1470	21	in	in	IN
cord-022353-q2k2krnm	1470	22	mice	mouse	NNS
cord-022353-q2k2krnm	1470	23	Uncoupling	uncouple	VBG
cord-022353-q2k2krnm	1470	24	of	of	IN
cord-022353-q2k2krnm	1470	25	obesity	obesity	NN
cord-022353-q2k2krnm	1470	26	from	from	IN
cord-022353-q2k2krnm	1470	27	insulin	insulin	NN
cord-022353-q2k2krnm	1470	28	resistance	resistance	NN
cord-022353-q2k2krnm	1470	29	through	through	IN
cord-022353-q2k2krnm	1470	30	a	a	DT
cord-022353-q2k2krnm	1470	31	targeted	target	VBN
cord-022353-q2k2krnm	1470	32	mutation	mutation	NN
cord-022353-q2k2krnm	1470	33	in	in	IN
cord-022353-q2k2krnm	1470	34	a	a	DT
cord-022353-q2k2krnm	1470	35	P2	P2	NNP
cord-022353-q2k2krnm	1470	36	,	,	,
cord-022353-q2k2krnm	1470	37	the	the	DT
cord-022353-q2k2krnm	1470	38	adipocyte	adipocyte	JJ
cord-022353-q2k2krnm	1470	39	fatty	fatty	JJ
cord-022353-q2k2krnm	1470	40	acid	acid	NN
cord-022353-q2k2krnm	1470	41	binding	bind	VBG
cord-022353-q2k2krnm	1470	42	protein	protein	NN
cord-022353-q2k2krnm	1470	43	Synergistic	synergistic	JJ
cord-022353-q2k2krnm	1470	44	effect	effect	NN
cord-022353-q2k2krnm	1470	45	of	of	IN
cord-022353-q2k2krnm	1470	46	lymphotactin	lymphotactin	NNP
cord-022353-q2k2krnm	1470	47	and	and	CC
cord-022353-q2k2krnm	1470	48	interferongamma	interferongamma	JJ
cord-022353-q2k2krnm	1470	49	-	-	HYPH
cord-022353-q2k2krnm	1470	50	inducible	inducible	JJ
cord-022353-q2k2krnm	1470	51	protein-10	protein-10	CD
cord-022353-q2k2krnm	1470	52	transgene	transgene	JJ
cord-022353-q2k2krnm	1470	53	expression	expression	NN
cord-022353-q2k2krnm	1470	54	in	in	IN
cord-022353-q2k2krnm	1470	55	T	t	NN
cord-022353-q2k2krnm	1470	56	-	-	HYPH
cord-022353-q2k2krnm	1470	57	cell	cell	NN
cord-022353-q2k2krnm	1470	58	localization	localization	NN
cord-022353-q2k2krnm	1470	59	and	and	CC
cord-022353-q2k2krnm	1470	60	adoptive	adoptive	JJ
cord-022353-q2k2krnm	1470	61	T	t	NN
cord-022353-q2k2krnm	1470	62	-	-	HYPH
cord-022353-q2k2krnm	1470	63	cell	cell	NN
cord-022353-q2k2krnm	1470	64	therapy	therapy	NN
cord-022353-q2k2krnm	1470	65	of	of	IN
cord-022353-q2k2krnm	1470	66	tumors	tumor	NNS
cord-022353-q2k2krnm	1471	1	Multidrug	multidrug	JJ
cord-022353-q2k2krnm	1471	2	resistance	resistance	NN
cord-022353-q2k2krnm	1471	3	p	p	NN
cord-022353-q2k2krnm	1471	4	-	-	HYPH
cord-022353-q2k2krnm	1471	5	glycoprotein	glycoprotein	NN
cord-022353-q2k2krnm	1471	6	2	2	CD
cord-022353-q2k2krnm	1471	7	is	be	VBZ
cord-022353-q2k2krnm	1471	8	essential	essential	JJ
cord-022353-q2k2krnm	1471	9	for	for	IN
cord-022353-q2k2krnm	1471	10	the	the	DT
cord-022353-q2k2krnm	1471	11	biliary	biliary	JJ
cord-022353-q2k2krnm	1471	12	excretion	excretion	NN
cord-022353-q2k2krnm	1471	13	of	of	IN
cord-022353-q2k2krnm	1471	14	indocyanine	indocyanine	NNP
cord-022353-q2k2krnm	1471	15	green	green	NNP
cord-022353-q2k2krnm	1471	16	Induction	Induction	NNP
cord-022353-q2k2krnm	1471	17	of	of	IN
cord-022353-q2k2krnm	1471	18	bilirubin	bilirubin	JJ
cord-022353-q2k2krnm	1471	19	clearance	clearance	NN
cord-022353-q2k2krnm	1471	20	by	by	IN
cord-022353-q2k2krnm	1471	21	the	the	DT
cord-022353-q2k2krnm	1471	22	constitutive	constitutive	JJ
cord-022353-q2k2krnm	1471	23	androstane	androstane	NNP
cord-022353-q2k2krnm	1471	24	receptor	receptor	NN
cord-022353-q2k2krnm	1471	25	A	a	DT
cord-022353-q2k2krnm	1471	26	traditional	traditional	JJ
cord-022353-q2k2krnm	1471	27	herbal	herbal	JJ
cord-022353-q2k2krnm	1471	28	medicine	medicine	NN
cord-022353-q2k2krnm	1471	29	enhances	enhance	VBZ
cord-022353-q2k2krnm	1471	30	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1471	31	clearance	clearance	NN
cord-022353-q2k2krnm	1471	32	by	by	IN
cord-022353-q2k2krnm	1471	33	activating	activate	VBG
cord-022353-q2k2krnm	1471	34	the	the	DT
cord-022353-q2k2krnm	1471	35	nuclear	nuclear	JJ
cord-022353-q2k2krnm	1471	36	receptor	receptor	NN
cord-022353-q2k2krnm	1471	37	CAR	CAR	NNP
cord-022353-q2k2krnm	1471	38	Visfatin	Visfatin	NNP
cord-022353-q2k2krnm	1471	39	:	:	:
cord-022353-q2k2krnm	1471	40	a	a	DT
cord-022353-q2k2krnm	1471	41	new	new	JJ
cord-022353-q2k2krnm	1471	42	adipokine	adipokine	NNP
cord-022353-q2k2krnm	1471	43	Transgenic	Transgenic	NNP
cord-022353-q2k2krnm	1471	44	and	and	CC
cord-022353-q2k2krnm	1471	45	KO	KO	NNP
cord-022353-q2k2krnm	1471	46	mouse	mouse	NN
cord-022353-q2k2krnm	1471	47	models	model	NNS
cord-022353-q2k2krnm	1471	48	for	for	IN
cord-022353-q2k2krnm	1471	49	the	the	DT
cord-022353-q2k2krnm	1471	50	study	study	NN
cord-022353-q2k2krnm	1471	51	of	of	IN
cord-022353-q2k2krnm	1471	52	luteinizing	luteinize	VBG
cord-022353-q2k2krnm	1471	53	hormone	hormone	NN
cord-022353-q2k2krnm	1471	54	and	and	CC
cord-022353-q2k2krnm	1471	55	luteinizing	luteinize	VBG
cord-022353-q2k2krnm	1471	56	hormone	hormone	NN
cord-022353-q2k2krnm	1471	57	reception	reception	NN
cord-022353-q2k2krnm	1471	58	function	function	NN
cord-022353-q2k2krnm	1471	59	Loperamide	loperamide	NN
cord-022353-q2k2krnm	1471	60	effects	effect	NNS
cord-022353-q2k2krnm	1471	61	on	on	IN
cord-022353-q2k2krnm	1471	62	hepatobiliary	hepatobiliary	JJ
cord-022353-q2k2krnm	1471	63	function	function	NN
cord-022353-q2k2krnm	1471	64	,	,	,
cord-022353-q2k2krnm	1471	65	intestinal	intestinal	JJ
cord-022353-q2k2krnm	1471	66	transit	transit	NN
cord-022353-q2k2krnm	1471	67	,	,	,
cord-022353-q2k2krnm	1471	68	and	and	CC
cord-022353-q2k2krnm	1471	69	analgesia	analgesia	NN
cord-022353-q2k2krnm	1471	70	in	in	IN
cord-022353-q2k2krnm	1471	71	mice	mouse	NNS
cord-022353-q2k2krnm	1471	72	Redox	Redox	NNP
cord-022353-q2k2krnm	1471	73	state	state	NN
cord-022353-q2k2krnm	1471	74	-	-	HYPH
cord-022353-q2k2krnm	1471	75	dependent	dependent	JJ
cord-022353-q2k2krnm	1471	76	and	and	CC
cord-022353-q2k2krnm	1471	77	sorbitol	sorbitol	NN
cord-022353-q2k2krnm	1471	78	accumulationindependent	accumulationindependent	NN
cord-022353-q2k2krnm	1471	79	diabetic	diabetic	NNP
cord-022353-q2k2krnm	1471	80	albuminaria	albuminaria	NNP
cord-022353-q2k2krnm	1471	81	in	in	IN
cord-022353-q2k2krnm	1471	82	mice	mouse	NNS
cord-022353-q2k2krnm	1471	83	with	with	IN
cord-022353-q2k2krnm	1471	84	transgene	transgene	NN
cord-022353-q2k2krnm	1471	85	-	-	HYPH
cord-022353-q2k2krnm	1471	86	derived	derive	VBN
cord-022353-q2k2krnm	1471	87	human	human	JJ
cord-022353-q2k2krnm	1471	88	aldose	aldose	NNS
cord-022353-q2k2krnm	1471	89	reductase	reductase	NN
cord-022353-q2k2krnm	1471	90	and	and	CC
cord-022353-q2k2krnm	1472	1	sorbitol	sorbitol	NN
cord-022353-q2k2krnm	1472	2	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	1472	3	deficiency	deficiency	NN
cord-022353-q2k2krnm	1473	1	Hepatocyte	Hepatocyte	NNP
cord-022353-q2k2krnm	1473	2	nuclear	nuclear	JJ
cord-022353-q2k2krnm	1473	3	factor	factor	NN
cord-022353-q2k2krnm	1473	4	4	4	CD
cord-022353-q2k2krnm	1473	5	alpha	alpha	NN
cord-022353-q2k2krnm	1473	6	is	be	VBZ
cord-022353-q2k2krnm	1473	7	a	a	DT
cord-022353-q2k2krnm	1473	8	central	central	JJ
cord-022353-q2k2krnm	1473	9	regulator	regulator	NN
cord-022353-q2k2krnm	1473	10	of	of	IN
cord-022353-q2k2krnm	1473	11	bile	bile	NN
cord-022353-q2k2krnm	1473	12	acid	acid	NN
cord-022353-q2k2krnm	1473	13	conjugation	conjugation	NN
cord-022353-q2k2krnm	1473	14	Genetic	Genetic	NNP
cord-022353-q2k2krnm	1473	15	Association	Association	NNP
cord-022353-q2k2krnm	1473	16	Between	between	IN
cord-022353-q2k2krnm	1473	17	H-2	H-2	NNP
cord-022353-q2k2krnm	1473	18	Gene	Gene	NNP
cord-022353-q2k2krnm	1473	19	and	and	CC
cord-022353-q2k2krnm	1473	20	Testosterone	testosterone	NN
cord-022353-q2k2krnm	1473	21	Metabolism	metabolism	NN
cord-022353-q2k2krnm	1473	22	in	in	IN
cord-022353-q2k2krnm	1473	23	Mice	mice	NN
cord-022353-q2k2krnm	1473	24	Use	Use	NNP
cord-022353-q2k2krnm	1473	25	of	of	IN
cord-022353-q2k2krnm	1473	26	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1473	27	mice	mouse	NNS
cord-022353-q2k2krnm	1473	28	in	in	IN
cord-022353-q2k2krnm	1473	29	carcinogenicity	carcinogenicity	NN
cord-022353-q2k2krnm	1473	30	hazard	hazard	NN
cord-022353-q2k2krnm	1473	31	assessment	assessment	NN
cord-022353-q2k2krnm	1473	32	Leukotrienes	leukotriene	NNS
cord-022353-q2k2krnm	1473	33	and	and	CC
cord-022353-q2k2krnm	1473	34	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1473	35	:	:	:
cord-022353-q2k2krnm	1473	36	new	new	JJ
cord-022353-q2k2krnm	1473	37	roles	role	NNS
cord-022353-q2k2krnm	1473	38	for	for	IN
cord-022353-q2k2krnm	1473	39	old	old	JJ
cord-022353-q2k2krnm	1473	40	mediators	mediator	NNS
cord-022353-q2k2krnm	1473	41	Endothelial	endothelial	JJ
cord-022353-q2k2krnm	1473	42	lipase	lipase	NN
cord-022353-q2k2krnm	1473	43	and	and	CC
cord-022353-q2k2krnm	1473	44	HDL	hdl	NN
cord-022353-q2k2krnm	1473	45	metabolism	metabolism	NN
cord-022353-q2k2krnm	1473	46	Targeted	target	VBN
cord-022353-q2k2krnm	1473	47	mutation	mutation	NN
cord-022353-q2k2krnm	1473	48	of	of	IN
cord-022353-q2k2krnm	1473	49	plasma	plasma	NN
cord-022353-q2k2krnm	1473	50	phospholipids	phospholipid	NNS
cord-022353-q2k2krnm	1473	51	transfer	transfer	NN
cord-022353-q2k2krnm	1473	52	protein	protein	NN
cord-022353-q2k2krnm	1473	53	gene	gene	NN
cord-022353-q2k2krnm	1473	54	markedly	markedly	RB
cord-022353-q2k2krnm	1473	55	reduces	reduce	VBZ
cord-022353-q2k2krnm	1473	56	high	high	JJ
cord-022353-q2k2krnm	1473	57	density	density	NN
cord-022353-q2k2krnm	1473	58	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	1473	59	levels	level	NNS
cord-022353-q2k2krnm	1473	60	Genetic	genetic	JJ
cord-022353-q2k2krnm	1473	61	heterogeneity	heterogeneity	NN
cord-022353-q2k2krnm	1473	62	of	of	IN
cord-022353-q2k2krnm	1473	63	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	1473	64	in	in	IN
cord-022353-q2k2krnm	1473	65	inbred	inbred	JJ
cord-022353-q2k2krnm	1473	66	strains	strain	NNS
cord-022353-q2k2krnm	1473	67	of	of	IN
cord-022353-q2k2krnm	1473	68	mice	mouse	NNS
cord-022353-q2k2krnm	1473	69	:	:	:
cord-022353-q2k2krnm	1473	70	analysis	analysis	NN
cord-022353-q2k2krnm	1473	71	by	by	IN
cord-022353-q2k2krnm	1473	72	gel	gel	NN
cord-022353-q2k2krnm	1473	73	permeation	permeation	NN
cord-022353-q2k2krnm	1473	74	chromatography	chromatography	NN
cord-022353-q2k2krnm	1473	75	AFP	AFP	NNP
cord-022353-q2k2krnm	1473	76	gene	gene	NN
cord-022353-q2k2krnm	1473	77	expression	expression	NN
cord-022353-q2k2krnm	1473	78	after	after	IN
cord-022353-q2k2krnm	1473	79	acute	acute	JJ
cord-022353-q2k2krnm	1473	80	diethylnitrosamine	diethylnitrosamine	NN
cord-022353-q2k2krnm	1473	81	intoxication	intoxication	NN
cord-022353-q2k2krnm	1473	82	is	be	VBZ
cord-022353-q2k2krnm	1473	83	not	not	RB
cord-022353-q2k2krnm	1473	84	Afr2	Afr2	NNP
cord-022353-q2k2krnm	1473	85	regulated	regulate	VBN
cord-022353-q2k2krnm	1473	86	Identification	identification	NN
cord-022353-q2k2krnm	1473	87	of	of	IN
cord-022353-q2k2krnm	1473	88	tumor	tumor	NN
cord-022353-q2k2krnm	1473	89	-	-	HYPH
cord-022353-q2k2krnm	1473	90	associated	associate	VBN
cord-022353-q2k2krnm	1473	91	plasma	plasma	NN
cord-022353-q2k2krnm	1473	92	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	1473	93	using	use	VBG
cord-022353-q2k2krnm	1473	94	proteomic	proteomic	JJ
cord-022353-q2k2krnm	1473	95	techniques	technique	NNS
cord-022353-q2k2krnm	1473	96	:	:	:
cord-022353-q2k2krnm	1473	97	from	from	IN
cord-022353-q2k2krnm	1473	98	mouse	mouse	NN
cord-022353-q2k2krnm	1473	99	to	to	IN
cord-022353-q2k2krnm	1473	100	human	human	JJ
cord-022353-q2k2krnm	1473	101	Role	role	NN
cord-022353-q2k2krnm	1473	102	of	of	IN
cord-022353-q2k2krnm	1473	103	liver	liver	NN
cord-022353-q2k2krnm	1473	104	enriched	enrich	VBN
cord-022353-q2k2krnm	1473	105	transcription	transcription	NN
cord-022353-q2k2krnm	1473	106	factors	factor	NNS
cord-022353-q2k2krnm	1473	107	and	and	CC
cord-022353-q2k2krnm	1473	108	nuclear	nuclear	JJ
cord-022353-q2k2krnm	1473	109	receptors	receptor	NNS
cord-022353-q2k2krnm	1473	110	in	in	IN
cord-022353-q2k2krnm	1473	111	regulating	regulate	VBG
cord-022353-q2k2krnm	1473	112	the	the	DT
cord-022353-q2k2krnm	1473	113	human	human	NN
cord-022353-q2k2krnm	1473	114	,	,	,
cord-022353-q2k2krnm	1473	115	mouse	mouse	NN
cord-022353-q2k2krnm	1473	116	,	,	,
cord-022353-q2k2krnm	1473	117	rand	rand	NNP
cord-022353-q2k2krnm	1473	118	rat	rat	NNP
cord-022353-q2k2krnm	1473	119	NTCP	NTCP	NNP
cord-022353-q2k2krnm	1473	120	gene	gene	NN
cord-022353-q2k2krnm	1473	121	Expression	expression	NN
cord-022353-q2k2krnm	1473	122	of	of	IN
cord-022353-q2k2krnm	1473	123	urea	urea	NN
cord-022353-q2k2krnm	1473	124	transporters	transporter	NNS
cord-022353-q2k2krnm	1473	125	in	in	IN
cord-022353-q2k2krnm	1473	126	potassium	potassium	NN
cord-022353-q2k2krnm	1473	127	-	-	HYPH
cord-022353-q2k2krnm	1473	128	depleted	deplete	VBN
cord-022353-q2k2krnm	1473	129	mouse	mouse	NN
cord-022353-q2k2krnm	1473	130	kidney	kidney	NN
cord-022353-q2k2krnm	1473	131	Genetic	genetic	JJ
cord-022353-q2k2krnm	1473	132	analysis	analysis	NN
cord-022353-q2k2krnm	1473	133	of	of	IN
cord-022353-q2k2krnm	1473	134	glucose	glucose	NN
cord-022353-q2k2krnm	1473	135	tolerance	tolerance	NN
cord-022353-q2k2krnm	1473	136	in	in	IN
cord-022353-q2k2krnm	1473	137	inbred	inbred	JJ
cord-022353-q2k2krnm	1473	138	mouse	mouse	NN
cord-022353-q2k2krnm	1473	139	strains	strain	NNS
cord-022353-q2k2krnm	1473	140	.	.	.
cord-022353-q2k2krnm	1474	1	Evidence	evidence	NN
cord-022353-q2k2krnm	1474	2	for	for	IN
cord-022353-q2k2krnm	1474	3	polygenic	polygenic	JJ
cord-022353-q2k2krnm	1474	4	control	control	NN
cord-022353-q2k2krnm	1474	5	Reversing	reverse	VBG
cord-022353-q2k2krnm	1474	6	systemic	systemic	JJ
cord-022353-q2k2krnm	1474	7	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	1474	8	response	response	NN
cord-022353-q2k2krnm	1474	9	syndrome	syndrome	NN
cord-022353-q2k2krnm	1474	10	with	with	IN
cord-022353-q2k2krnm	1474	11	chemokine	chemokine	NN
cord-022353-q2k2krnm	1474	12	receptor	receptor	NN
cord-022353-q2k2krnm	1474	13	pepducins	pepducin	VBZ
cord-022353-q2k2krnm	1474	14	Carbohydrate	Carbohydrate	NNP
cord-022353-q2k2krnm	1474	15	metabolism	metabolism	NN
cord-022353-q2k2krnm	1474	16	Proteomic	Proteomic	NNP
cord-022353-q2k2krnm	1474	17	fingerprints	fingerprint	NNS
cord-022353-q2k2krnm	1474	18	for	for	IN
cord-022353-q2k2krnm	1474	19	potential	potential	JJ
cord-022353-q2k2krnm	1474	20	application	application	NN
cord-022353-q2k2krnm	1474	21	to	to	IN
cord-022353-q2k2krnm	1474	22	early	early	JJ
cord-022353-q2k2krnm	1474	23	diagnosis	diagnosis	NN
cord-022353-q2k2krnm	1474	24	of	of	IN
cord-022353-q2k2krnm	1474	25	severe	severe	JJ
cord-022353-q2k2krnm	1474	26	acute	acute	JJ
cord-022353-q2k2krnm	1474	27	respiratory	respiratory	JJ
cord-022353-q2k2krnm	1474	28	syndrome	syndrome	NN
cord-022353-q2k2krnm	1475	1	IL-6	IL-6	NNP
cord-022353-q2k2krnm	1475	2	:	:	:
cord-022353-q2k2krnm	1475	3	a	a	DT
cord-022353-q2k2krnm	1475	4	regulator	regulator	NN
cord-022353-q2k2krnm	1475	5	of	of	IN
cord-022353-q2k2krnm	1475	6	the	the	DT
cord-022353-q2k2krnm	1475	7	transition	transition	NN
cord-022353-q2k2krnm	1475	8	from	from	IN
cord-022353-q2k2krnm	1475	9	neutrophil	neutrophil	NN
cord-022353-q2k2krnm	1475	10	to	to	IN
cord-022353-q2k2krnm	1475	11	monocyte	monocyte	NNP
cord-022353-q2k2krnm	1475	12	recruitment	recruitment	NN
cord-022353-q2k2krnm	1475	13	during	during	IN
cord-022353-q2k2krnm	1475	14	inflammation	inflammation	NN
cord-022353-q2k2krnm	1475	15	Implications	implication	NNS
cord-022353-q2k2krnm	1475	16	of	of	IN
cord-022353-q2k2krnm	1475	17	multiple	multiple	JJ
cord-022353-q2k2krnm	1475	18	phenotypes	phenotype	NNS
cord-022353-q2k2krnm	1475	19	observed	observe	VBN
cord-022353-q2k2krnm	1475	20	in	in	IN
cord-022353-q2k2krnm	1475	21	prolactin	prolactin	NN
cord-022353-q2k2krnm	1475	22	receptor	receptor	NN
cord-022353-q2k2krnm	1475	23	KO	KO	NNP
cord-022353-q2k2krnm	1475	24	mice	mouse	NNS
cord-022353-q2k2krnm	1475	25	.	.	.
cord-022353-q2k2krnm	1476	1	Front	Front	NNP
cord-022353-q2k2krnm	1476	2	Neuroendocrino122	Neuroendocrino122	NNP
cord-022353-q2k2krnm	1476	3	Vectorial	Vectorial	NNP
cord-022353-q2k2krnm	1476	4	transport	transport	NN
cord-022353-q2k2krnm	1476	5	of	of	IN
cord-022353-q2k2krnm	1476	6	bile	bile	NN
cord-022353-q2k2krnm	1476	7	acids	acid	NNS
cord-022353-q2k2krnm	1476	8	in	in	IN
cord-022353-q2k2krnm	1476	9	immortalized	immortalize	VBN
cord-022353-q2k2krnm	1476	10	mouse	mouse	NN
cord-022353-q2k2krnm	1476	11	bile	bile	NN
cord-022353-q2k2krnm	1476	12	duct	duct	NN
cord-022353-q2k2krnm	1476	13	cells	cell	NNS
cord-022353-q2k2krnm	1476	14	Hyperadrenocorticism	Hyperadrenocorticism	NNP
cord-022353-q2k2krnm	1476	15	,	,	,
cord-022353-q2k2krnm	1476	16	attenuated	attenuated	JJ
cord-022353-q2k2krnm	1476	17	inflammation	inflammation	NN
cord-022353-q2k2krnm	1476	18	,	,	,
cord-022353-q2k2krnm	1476	19	and	and	CC
cord-022353-q2k2krnm	1476	20	the	the	DT
cord-022353-q2k2krnm	1476	21	life	life	NN
cord-022353-q2k2krnm	1476	22	prolonging	prolong	VBG
cord-022353-q2k2krnm	1476	23	action	action	NN
cord-022353-q2k2krnm	1476	24	of	of	IN
cord-022353-q2k2krnm	1476	25	food	food	NN
cord-022353-q2k2krnm	1476	26	restriction	restriction	NN
cord-022353-q2k2krnm	1476	27	in	in	IN
cord-022353-q2k2krnm	1476	28	mice	mouse	NNS
cord-022353-q2k2krnm	1476	29	Physiological	physiological	JJ
cord-022353-q2k2krnm	1476	30	relevance	relevance	NN
cord-022353-q2k2krnm	1476	31	of	of	IN
cord-022353-q2k2krnm	1476	32	thyroid	thyroid	NN
cord-022353-q2k2krnm	1476	33	stimulating	stimulate	VBG
cord-022353-q2k2krnm	1476	34	hormone	hormone	NN
cord-022353-q2k2krnm	1476	35	and	and	CC
cord-022353-q2k2krnm	1476	36	thyroid	thyroid	NN
cord-022353-q2k2krnm	1476	37	stimulating	stimulate	VBG
cord-022353-q2k2krnm	1476	38	hormone	hormone	NN
cord-022353-q2k2krnm	1476	39	receptor	receptor	NN
cord-022353-q2k2krnm	1476	40	in	in	IN
cord-022353-q2k2krnm	1476	41	tissues	tissue	NNS
cord-022353-q2k2krnm	1476	42	other	other	JJ
cord-022353-q2k2krnm	1476	43	than	than	IN
cord-022353-q2k2krnm	1476	44	the	the	DT
cord-022353-q2k2krnm	1476	45	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1476	46	Genetic	genetic	JJ
cord-022353-q2k2krnm	1476	47	modifiers	modifier	NNS
cord-022353-q2k2krnm	1476	48	of	of	IN
cord-022353-q2k2krnm	1476	49	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1476	50	in	in	IN
cord-022353-q2k2krnm	1476	51	mice	mouse	NNS
cord-022353-q2k2krnm	1476	52	Function	Function	NNP
cord-022353-q2k2krnm	1476	53	of	of	IN
cord-022353-q2k2krnm	1476	54	prostanoid	prostanoid	NNP
cord-022353-q2k2krnm	1476	55	receptors	receptor	NNS
cord-022353-q2k2krnm	1476	56	:	:	:
cord-022353-q2k2krnm	1476	57	studies	study	NNS
cord-022353-q2k2krnm	1476	58	in	in	IN
cord-022353-q2k2krnm	1476	59	KO	KO	NNP
cord-022353-q2k2krnm	1476	60	mice	mouse	NNS
cord-022353-q2k2krnm	1477	1	Estrogen	estrogen	NN
cord-022353-q2k2krnm	1477	2	receptor	receptor	NN
cord-022353-q2k2krnm	1477	3	gene	gene	NN
cord-022353-q2k2krnm	1477	4	disruption	disruption	NN
cord-022353-q2k2krnm	1477	5	:	:	:
cord-022353-q2k2krnm	1478	1	molecular	molecular	JJ
cord-022353-q2k2krnm	1478	2	characterization	characterization	NN
cord-022353-q2k2krnm	1478	3	and	and	CC
cord-022353-q2k2krnm	1478	4	experimental	experimental	JJ
cord-022353-q2k2krnm	1478	5	and	and	CC
cord-022353-q2k2krnm	1478	6	clinical	clinical	JJ
cord-022353-q2k2krnm	1478	7	phenotypes	phenotype	NNS
cord-022353-q2k2krnm	1478	8	Ghrelin	Ghrelin	NNP
cord-022353-q2k2krnm	1478	9	--	--	:
cord-022353-q2k2krnm	1478	10	a	a	DT
cord-022353-q2k2krnm	1478	11	hormone	hormone	NN
cord-022353-q2k2krnm	1478	12	with	with	IN
cord-022353-q2k2krnm	1478	13	multiple	multiple	JJ
cord-022353-q2k2krnm	1478	14	functions	function	NNS
cord-022353-q2k2krnm	1478	15	Effects	effect	NNS
cord-022353-q2k2krnm	1478	16	of	of	IN
cord-022353-q2k2krnm	1478	17	shipping	shipping	NN
cord-022353-q2k2krnm	1478	18	on	on	IN
cord-022353-q2k2krnm	1478	19	immune	immune	JJ
cord-022353-q2k2krnm	1478	20	functions	function	NNS
cord-022353-q2k2krnm	1478	21	of	of	IN
cord-022353-q2k2krnm	1478	22	mice	mouse	NNS
cord-022353-q2k2krnm	1479	1	How	how	WRB
cord-022353-q2k2krnm	1479	2	obesity	obesity	NN
cord-022353-q2k2krnm	1479	3	causes	cause	VBZ
cord-022353-q2k2krnm	1479	4	diabetes	diabetes	NN
cord-022353-q2k2krnm	1479	5	:	:	:
cord-022353-q2k2krnm	1479	6	not	not	RB
cord-022353-q2k2krnm	1479	7	a	a	DT
cord-022353-q2k2krnm	1479	8	tall	tall	JJ
cord-022353-q2k2krnm	1479	9	tale	tale	NN
cord-022353-q2k2krnm	1480	1	Luteinizing	luteinize	VBG
cord-022353-q2k2krnm	1480	2	hormone	hormone	NN
cord-022353-q2k2krnm	1480	3	deficiency	deficiency	NN
cord-022353-q2k2krnm	1480	4	and	and	CC
cord-022353-q2k2krnm	1480	5	female	female	JJ
cord-022353-q2k2krnm	1480	6	infertility	infertility	NN
cord-022353-q2k2krnm	1480	7	Current	current	JJ
cord-022353-q2k2krnm	1480	8	protocols	protocol	NNS
cord-022353-q2k2krnm	1480	9	in	in	IN
cord-022353-q2k2krnm	1480	10	immunology	immunology	NN
cord-022353-q2k2krnm	1480	11	Disruption	disruption	NN
cord-022353-q2k2krnm	1480	12	of	of	IN
cord-022353-q2k2krnm	1480	13	the	the	DT
cord-022353-q2k2krnm	1480	14	TGF	TGF	NNP
cord-022353-q2k2krnm	1480	15	-	-	HYPH
cord-022353-q2k2krnm	1480	16	I	I	NNP
cord-022353-q2k2krnm	1480	17	]	]	-RRB-
cord-022353-q2k2krnm	1480	18	pathway	pathway	NN
cord-022353-q2k2krnm	1480	19	and	and	CC
cord-022353-q2k2krnm	1480	20	modeling	model	VBG
cord-022353-q2k2krnm	1480	21	human	human	JJ
cord-022353-q2k2krnm	1480	22	cancer	cancer	NN
cord-022353-q2k2krnm	1480	23	in	in	IN
cord-022353-q2k2krnm	1480	24	mice	mouse	NNS
cord-022353-q2k2krnm	1481	1	A	a	DT
cord-022353-q2k2krnm	1481	2	new	new	JJ
cord-022353-q2k2krnm	1481	3	technique	technique	NN
cord-022353-q2k2krnm	1481	4	for	for	IN
cord-022353-q2k2krnm	1481	5	obtaining	obtain	VBG
cord-022353-q2k2krnm	1481	6	blood	blood	NN
cord-022353-q2k2krnm	1481	7	from	from	IN
cord-022353-q2k2krnm	1481	8	mice	mouse	NNS
cord-022353-q2k2krnm	1481	9	Decay	decay	NN
cord-022353-q2k2krnm	1481	10	-	-	HYPH
cord-022353-q2k2krnm	1481	11	accelerating	accelerate	VBG
cord-022353-q2k2krnm	1481	12	factor	factor	NN
cord-022353-q2k2krnm	1481	13	confers	confer	VBZ
cord-022353-q2k2krnm	1481	14	protection	protection	NN
cord-022353-q2k2krnm	1481	15	against	against	IN
cord-022353-q2k2krnm	1481	16	complement	complement	NN
cord-022353-q2k2krnm	1481	17	-	-	HYPH
cord-022353-q2k2krnm	1481	18	mediated	mediate	VBN
cord-022353-q2k2krnm	1481	19	podocyte	podocyte	NNP
cord-022353-q2k2krnm	1481	20	injury	injury	NN
cord-022353-q2k2krnm	1481	21	in	in	IN
cord-022353-q2k2krnm	1481	22	acute	acute	JJ
cord-022353-q2k2krnm	1481	23	nephrotoxic	nephrotoxic	JJ
cord-022353-q2k2krnm	1481	24	nephritis	nephritis	NN
cord-022353-q2k2krnm	1481	25	Tissue	tissue	NN
cord-022353-q2k2krnm	1481	26	distribution	distribution	NN
cord-022353-q2k2krnm	1481	27	of	of	IN
cord-022353-q2k2krnm	1481	28	products	product	NNS
cord-022353-q2k2krnm	1481	29	of	of	IN
cord-022353-q2k2krnm	1481	30	the	the	DT
cord-022353-q2k2krnm	1481	31	mouse	mouse	NN
cord-022353-q2k2krnm	1481	32	decay	decay	NN
cord-022353-q2k2krnm	1481	33	-	-	HYPH
cord-022353-q2k2krnm	1481	34	accelerating	accelerate	VBG
cord-022353-q2k2krnm	1481	35	factor	factor	NN
cord-022353-q2k2krnm	1481	36	(	(	-LRB-
cord-022353-q2k2krnm	1481	37	DAF	DAF	NNP
cord-022353-q2k2krnm	1481	38	)	)	-RRB-
cord-022353-q2k2krnm	1481	39	genes	gene	NNS
cord-022353-q2k2krnm	1481	40	:	:	:
cord-022353-q2k2krnm	1481	41	exploitation	exploitation	NN
cord-022353-q2k2krnm	1481	42	of	of	IN
cord-022353-q2k2krnm	1481	43	a	a	DT
cord-022353-q2k2krnm	1481	44	Daf-1	Daf-1	NNP
cord-022353-q2k2krnm	1481	45	knockout	knockout	NN
cord-022353-q2k2krnm	1481	46	mouse	mouse	NN
cord-022353-q2k2krnm	1481	47	and	and	CC
cord-022353-q2k2krnm	1481	48	site	site	NN
cord-022353-q2k2krnm	1481	49	-	-	HYPH
cord-022353-q2k2krnm	1481	50	specific	specific	JJ
cord-022353-q2k2krnm	1481	51	monoclonal	monoclonal	JJ
cord-022353-q2k2krnm	1481	52	antibodies	antibody	NNS
cord-022353-q2k2krnm	1482	1	Linscott	Linscott	NNP
cord-022353-q2k2krnm	1482	2	's	's	POS
cord-022353-q2k2krnm	1482	3	directory	directory	NN
cord-022353-q2k2krnm	1482	4	of	of	IN
cord-022353-q2k2krnm	1482	5	immunological	immunological	JJ
cord-022353-q2k2krnm	1482	6	and	and	CC
cord-022353-q2k2krnm	1482	7	biological	biological	JJ
cord-022353-q2k2krnm	1482	8	reagents	reagent	NNS
cord-022353-q2k2krnm	1482	9	Clinical	clinical	JJ
cord-022353-q2k2krnm	1482	10	biochemistry	biochemistry	NN
cord-022353-q2k2krnm	1482	11	of	of	IN
cord-022353-q2k2krnm	1482	12	laboratory	laboratory	NN
cord-022353-q2k2krnm	1482	13	rodents	rodent	NNS
cord-022353-q2k2krnm	1482	14	and	and	CC
cord-022353-q2k2krnm	1482	15	rabbits	rabbit	NNS
cord-022353-q2k2krnm	1482	16	.	.	.
cord-022353-q2k2krnm	1483	1	In	in	IN
cord-022353-q2k2krnm	1483	2	Clinical	clinical	JJ
cord-022353-q2k2krnm	1483	3	biochemistry	biochemistry	NN
cord-022353-q2k2krnm	1483	4	of	of	IN
cord-022353-q2k2krnm	1483	5	domestic	domestic	JJ
cord-022353-q2k2krnm	1483	6	animals	animal	NNS
cord-022353-q2k2krnm	1483	7	Clinical	clinical	JJ
cord-022353-q2k2krnm	1483	8	biochemistry	biochemistry	NN
cord-022353-q2k2krnm	1484	1	The	the	DT
cord-022353-q2k2krnm	1484	2	clinical	clinical	JJ
cord-022353-q2k2krnm	1484	3	chemistry	chemistry	NN
cord-022353-q2k2krnm	1484	4	of	of	IN
cord-022353-q2k2krnm	1484	5	laboratory	laboratory	NN
cord-022353-q2k2krnm	1484	6	animals	animal	NNS
cord-022353-q2k2krnm	1484	7	Improved	improve	VBD
cord-022353-q2k2krnm	1484	8	terminal	terminal	JJ
cord-022353-q2k2krnm	1484	9	bleeding	bleeding	NN
cord-022353-q2k2krnm	1484	10	method	method	NN
cord-022353-q2k2krnm	1484	11	T	t	NN
cord-022353-q2k2krnm	1484	12	-	-	HYPH
cord-022353-q2k2krnm	1484	13	cell	cell	NN
cord-022353-q2k2krnm	1484	14	trafficking	trafficking	NN
cord-022353-q2k2krnm	1484	15	in	in	IN
cord-022353-q2k2krnm	1484	16	asthma	asthma	NN
cord-022353-q2k2krnm	1484	17	:	:	:
cord-022353-q2k2krnm	1484	18	lipid	lipid	NN
cord-022353-q2k2krnm	1484	19	mediators	mediator	NNS
cord-022353-q2k2krnm	1484	20	grease	grease	VBP
cord-022353-q2k2krnm	1484	21	the	the	DT
cord-022353-q2k2krnm	1484	22	way	way	NN
cord-022353-q2k2krnm	1484	23	The	the	DT
cord-022353-q2k2krnm	1484	24	mouse	mouse	NN
cord-022353-q2k2krnm	1484	25	Fas	Fas	NNP
cord-022353-q2k2krnm	1484	26	-	-	HYPH
cord-022353-q2k2krnm	1484	27	ligand	ligand	NN
cord-022353-q2k2krnm	1484	28	gene	gene	NN
cord-022353-q2k2krnm	1484	29	is	be	VBZ
cord-022353-q2k2krnm	1484	30	mutated	mutate	VBN
cord-022353-q2k2krnm	1484	31	in	in	IN
cord-022353-q2k2krnm	1484	32	gld	gld	NNP
cord-022353-q2k2krnm	1484	33	mice	mouse	NNS
cord-022353-q2k2krnm	1484	34	and	and	CC
cord-022353-q2k2krnm	1484	35	is	be	VBZ
cord-022353-q2k2krnm	1484	36	part	part	NN
cord-022353-q2k2krnm	1484	37	of	of	IN
cord-022353-q2k2krnm	1484	38	a	a	DT
cord-022353-q2k2krnm	1484	39	TNF	TNF	NNP
cord-022353-q2k2krnm	1484	40	family	family	NN
cord-022353-q2k2krnm	1484	41	gene	gene	NN
cord-022353-q2k2krnm	1484	42	cluster	cluster	NN
cord-022353-q2k2krnm	1484	43	Chemokines	Chemokines	NNPS
cord-022353-q2k2krnm	1484	44	:	:	:
cord-022353-q2k2krnm	1484	45	immunology	immunology	NN
cord-022353-q2k2krnm	1484	46	's	's	POS
cord-022353-q2k2krnm	1484	47	high	high	JJ
cord-022353-q2k2krnm	1484	48	impact	impact	NN
cord-022353-q2k2krnm	1484	49	factors	factor	NNS
cord-022353-q2k2krnm	1484	50	Studies	Studies	NNPS
cord-022353-q2k2krnm	1484	51	on	on	IN
cord-022353-q2k2krnm	1484	52	the	the	DT
cord-022353-q2k2krnm	1484	53	origin	origin	NN
cord-022353-q2k2krnm	1484	54	and	and	CC
cord-022353-q2k2krnm	1484	55	excretion	excretion	NN
cord-022353-q2k2krnm	1484	56	of	of	IN
cord-022353-q2k2krnm	1484	57	serum	serum	NN
cord-022353-q2k2krnm	1484	58	alpha	alpha	NN
cord-022353-q2k2krnm	1484	59	-	-	HYPH
cord-022353-q2k2krnm	1484	60	amylase	amylase	NN
cord-022353-q2k2krnm	1484	61	in	in	IN
cord-022353-q2k2krnm	1484	62	the	the	DT
cord-022353-q2k2krnm	1484	63	mouse	mouse	NN
cord-022353-q2k2krnm	1484	64	Repetitive	repetitive	JJ
cord-022353-q2k2krnm	1484	65	blood	blood	NN
cord-022353-q2k2krnm	1484	66	sampling	sampling	NN
cord-022353-q2k2krnm	1484	67	in	in	IN
cord-022353-q2k2krnm	1484	68	unrestrained	unrestrained	JJ
cord-022353-q2k2krnm	1484	69	mice	mouse	NNS
cord-022353-q2k2krnm	1484	70	using	use	VBG
cord-022353-q2k2krnm	1484	71	a	a	DT
cord-022353-q2k2krnm	1484	72	chronic	chronic	JJ
cord-022353-q2k2krnm	1484	73	indwelling	indwell	VBG
cord-022353-q2k2krnm	1484	74	right	right	JJ
cord-022353-q2k2krnm	1484	75	atrial	atrial	JJ
cord-022353-q2k2krnm	1484	76	catheterization	catheterization	NN
cord-022353-q2k2krnm	1484	77	apparatus	apparatus	NN
cord-022353-q2k2krnm	1484	78	Transcellular	Transcellular	NNP
cord-022353-q2k2krnm	1484	79	biosynthesis	biosynthesis	NN
cord-022353-q2k2krnm	1484	80	of	of	IN
cord-022353-q2k2krnm	1484	81	arachidonic	arachidonic	JJ
cord-022353-q2k2krnm	1484	82	acid	acid	JJ
cord-022353-q2k2krnm	1484	83	metabolites	metabolite	NNS
cord-022353-q2k2krnm	1484	84	:	:	:
cord-022353-q2k2krnm	1484	85	from	from	IN
cord-022353-q2k2krnm	1484	86	in	in	IN
cord-022353-q2k2krnm	1484	87	vitro	vitro	FW
cord-022353-q2k2krnm	1484	88	investigations	investigation	NNS
cord-022353-q2k2krnm	1484	89	to	to	IN
cord-022353-q2k2krnm	1484	90	in	in	IN
cord-022353-q2k2krnm	1484	91	vivo	vivo	NN
cord-022353-q2k2krnm	1484	92	reality	reality	NN
cord-022353-q2k2krnm	1484	93	Consequences	consequence	NNS
cord-022353-q2k2krnm	1484	94	of	of	IN
cord-022353-q2k2krnm	1484	95	elevated	elevated	JJ
cord-022353-q2k2krnm	1484	96	luteinizing	luteinizing	JJ
cord-022353-q2k2krnm	1484	97	hormone	hormone	NN
cord-022353-q2k2krnm	1484	98	on	on	IN
cord-022353-q2k2krnm	1484	99	diverse	diverse	JJ
cord-022353-q2k2krnm	1484	100	physiological	physiological	JJ
cord-022353-q2k2krnm	1484	101	systems	system	NNS
cord-022353-q2k2krnm	1484	102	:	:	:
cord-022353-q2k2krnm	1484	103	use	use	NN
cord-022353-q2k2krnm	1484	104	of	of	IN
cord-022353-q2k2krnm	1484	105	the	the	DT
cord-022353-q2k2krnm	1484	106	LH	LH	NNP
cord-022353-q2k2krnm	1484	107	beta	beta	NN
cord-022353-q2k2krnm	1484	108	CTP	CTP	NNP
cord-022353-q2k2krnm	1484	109	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1484	110	mouse	mouse	NN
cord-022353-q2k2krnm	1484	111	as	as	IN
cord-022353-q2k2krnm	1484	112	a	a	DT
cord-022353-q2k2krnm	1484	113	model	model	NN
cord-022353-q2k2krnm	1484	114	of	of	IN
cord-022353-q2k2krnm	1484	115	ovarian	ovarian	JJ
cord-022353-q2k2krnm	1484	116	hyperstimulation	hyperstimulation	NN
cord-022353-q2k2krnm	1484	117	-	-	HYPH
cord-022353-q2k2krnm	1484	118	induced	induce	VBN
cord-022353-q2k2krnm	1484	119	pathophysiology	pathophysiology	NN
cord-022353-q2k2krnm	1484	120	Mouse	mouse	NN
cord-022353-q2k2krnm	1484	121	models	model	NNS
cord-022353-q2k2krnm	1484	122	as	as	IN
cord-022353-q2k2krnm	1484	123	tools	tool	NNS
cord-022353-q2k2krnm	1484	124	for	for	IN
cord-022353-q2k2krnm	1484	125	dissecting	dissect	VBG
cord-022353-q2k2krnm	1484	126	disorders	disorder	NNS
cord-022353-q2k2krnm	1484	127	of	of	IN
cord-022353-q2k2krnm	1484	128	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	1484	129	metabolism	metabolism	NN
cord-022353-q2k2krnm	1484	130	CCL19	CCL19	NNP
cord-022353-q2k2krnm	1484	131	and	and	CC
cord-022353-q2k2krnm	1484	132	CCL21	CCL21	NNP
cord-022353-q2k2krnm	1484	133	induce	induce	VB
cord-022353-q2k2krnm	1484	134	a	a	DT
cord-022353-q2k2krnm	1484	135	potent	potent	JJ
cord-022353-q2k2krnm	1484	136	proinflammatory	proinflammatory	JJ
cord-022353-q2k2krnm	1484	137	differentiation	differentiation	NN
cord-022353-q2k2krnm	1484	138	program	program	NN
cord-022353-q2k2krnm	1484	139	in	in	IN
cord-022353-q2k2krnm	1484	140	licensed	licensed	JJ
cord-022353-q2k2krnm	1484	141	dendritic	dendritic	JJ
cord-022353-q2k2krnm	1484	142	cells	cell	NNS
cord-022353-q2k2krnm	1485	1	The	the	DT
cord-022353-q2k2krnm	1485	2	role	role	NN
cord-022353-q2k2krnm	1485	3	of	of	IN
cord-022353-q2k2krnm	1485	4	histamine	histamine	NN
cord-022353-q2k2krnm	1485	5	HI	HI	NNP
cord-022353-q2k2krnm	1485	6	receptor	receptor	NN
cord-022353-q2k2krnm	1485	7	and	and	CC
cord-022353-q2k2krnm	1485	8	H2	H2	NNP
cord-022353-q2k2krnm	1485	9	receptor	receptor	NN
cord-022353-q2k2krnm	1485	10	in	in	IN
cord-022353-q2k2krnm	1486	1	LPS	LPS	NNP
cord-022353-q2k2krnm	1486	2	-	-	HYPH
cord-022353-q2k2krnm	1486	3	induced	induce	VBN
cord-022353-q2k2krnm	1486	4	liver	liver	NN
cord-022353-q2k2krnm	1486	5	injury	injury	NN
cord-022353-q2k2krnm	1486	6	Adiponectin	Adiponectin	NNP
cord-022353-q2k2krnm	1486	7	protects	protect	VBZ
cord-022353-q2k2krnm	1486	8	LPS	LPS	NNP
cord-022353-q2k2krnm	1486	9	-	-	HYPH
cord-022353-q2k2krnm	1486	10	induced	induce	VBN
cord-022353-q2k2krnm	1486	11	liver	liver	NN
cord-022353-q2k2krnm	1486	12	injury	injury	NN
cord-022353-q2k2krnm	1486	13	through	through	IN
cord-022353-q2k2krnm	1486	14	modification	modification	NN
cord-022353-q2k2krnm	1486	15	of	of	IN
cord-022353-q2k2krnm	1486	16	TNF	TNF	NNP
cord-022353-q2k2krnm	1486	17	-	-	HYPH
cord-022353-q2k2krnm	1486	18	t~	t~	NNP
cord-022353-q2k2krnm	1486	19	in	in	IN
cord-022353-q2k2krnm	1486	20	KK	KK	NNP
cord-022353-q2k2krnm	1486	21	-	-	HYPH
cord-022353-q2k2krnm	1486	22	Ay	Ay	NNP
cord-022353-q2k2krnm	1486	23	obese	obese	JJ
cord-022353-q2k2krnm	1486	24	mice	mouse	NNS
cord-022353-q2k2krnm	1487	1	In	in	IN
cord-022353-q2k2krnm	1487	2	vivo	vivo	NNP
cord-022353-q2k2krnm	1487	3	administration	administration	NN
cord-022353-q2k2krnm	1487	4	of	of	IN
cord-022353-q2k2krnm	1487	5	Helicobacter	Helicobacter	NNP
cord-022353-q2k2krnm	1487	6	hepaticus	hepaticus	NNP
cord-022353-q2k2krnm	1487	7	cytotoxin	cytotoxin	NNP
cord-022353-q2k2krnm	1487	8	is	be	VBZ
cord-022353-q2k2krnm	1487	9	associated	associate	VBN
cord-022353-q2k2krnm	1487	10	with	with	IN
cord-022353-q2k2krnm	1487	11	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1487	12	inflammation	inflammation	NN
cord-022353-q2k2krnm	1487	13	and	and	CC
cord-022353-q2k2krnm	1487	14	necrosis	necrosis	NN
cord-022353-q2k2krnm	1488	1	An	an	DT
cord-022353-q2k2krnm	1488	2	H-2-associated	H-2-associated	NNP
cord-022353-q2k2krnm	1488	3	difference	difference	NN
cord-022353-q2k2krnm	1488	4	in	in	IN
cord-022353-q2k2krnm	1488	5	murine	murine	JJ
cord-022353-q2k2krnm	1488	6	serum	serum	NN
cord-022353-q2k2krnm	1488	7	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1488	8	levels	level	NNS
cord-022353-q2k2krnm	1488	9	Tissue	tissue	NN
cord-022353-q2k2krnm	1488	10	-	-	HYPH
cord-022353-q2k2krnm	1488	11	specific	specific	JJ
cord-022353-q2k2krnm	1488	12	expression	expression	NN
cord-022353-q2k2krnm	1488	13	of	of	IN
cord-022353-q2k2krnm	1488	14	the	the	DT
cord-022353-q2k2krnm	1488	15	human	human	JJ
cord-022353-q2k2krnm	1488	16	gene	gene	NN
cord-022353-q2k2krnm	1488	17	for	for	IN
cord-022353-q2k2krnm	1488	18	lecithin	lecithin	NN
cord-022353-q2k2krnm	1488	19	:	:	:
cord-022353-q2k2krnm	1488	20	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1488	21	acyltransferase	acyltransferase	NN
cord-022353-q2k2krnm	1488	22	in	in	IN
cord-022353-q2k2krnm	1488	23	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1488	24	mice	mouse	NNS
cord-022353-q2k2krnm	1488	25	alters	alter	VBZ
cord-022353-q2k2krnm	1488	26	blood	blood	NN
cord-022353-q2k2krnm	1488	27	lipids	lipid	NNS
cord-022353-q2k2krnm	1488	28	,	,	,
cord-022353-q2k2krnm	1488	29	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	1488	30	,	,	,
cord-022353-q2k2krnm	1488	31	and	and	CC
cord-022353-q2k2krnm	1488	32	lipases	lipase	NNS
cord-022353-q2k2krnm	1488	33	towards	towards	IN
cord-022353-q2k2krnm	1488	34	a	a	DT
cord-022353-q2k2krnm	1488	35	less	less	RBR
cord-022353-q2k2krnm	1488	36	atherogenic	atherogenic	JJ
cord-022353-q2k2krnm	1488	37	profile	profile	NN
cord-022353-q2k2krnm	1488	38	Biology	biology	NN
cord-022353-q2k2krnm	1488	39	of	of	IN
cord-022353-q2k2krnm	1489	1	IL-21	IL-21	NNP
cord-022353-q2k2krnm	1489	2	and	and	CC
cord-022353-q2k2krnm	1489	3	the	the	DT
cord-022353-q2k2krnm	1489	4	IL-21	IL-21	NNP
cord-022353-q2k2krnm	1489	5	receptor	receptor	NN
cord-022353-q2k2krnm	1489	6	Multiple	multiple	JJ
cord-022353-q2k2krnm	1489	7	genes	gene	NNS
cord-022353-q2k2krnm	1489	8	encode	encode	VBP
cord-022353-q2k2krnm	1489	9	mouse	mouse	NN
cord-022353-q2k2krnm	1489	10	pancreatic	pancreatic	NN
cord-022353-q2k2krnm	1489	11	amylases	amylase	NNS
cord-022353-q2k2krnm	1490	1	Opposing	oppose	VBG
cord-022353-q2k2krnm	1490	2	roles	role	NNS
cord-022353-q2k2krnm	1490	3	for	for	IN
cord-022353-q2k2krnm	1490	4	IL-13	IL-13	NNP
cord-022353-q2k2krnm	1490	5	and	and	CC
cord-022353-q2k2krnm	1490	6	IL-13	IL-13	NNP
cord-022353-q2k2krnm	1490	7	receptor	receptor	NN
cord-022353-q2k2krnm	1490	8	ct2	ct2	NN
cord-022353-q2k2krnm	1490	9	in	in	IN
cord-022353-q2k2krnm	1490	10	health	health	NN
cord-022353-q2k2krnm	1490	11	and	and	CC
cord-022353-q2k2krnm	1490	12	disease	disease	NN
cord-022353-q2k2krnm	1490	13	Of	of	IN
cord-022353-q2k2krnm	1490	14	mice	mouse	NNS
cord-022353-q2k2krnm	1490	15	and	and	CC
cord-022353-q2k2krnm	1490	16	not	not	RB
cord-022353-q2k2krnm	1490	17	men	man	NNS
cord-022353-q2k2krnm	1490	18	:	:	:
cord-022353-q2k2krnm	1490	19	differences	difference	NNS
cord-022353-q2k2krnm	1490	20	between	between	IN
cord-022353-q2k2krnm	1490	21	mouse	mouse	NN
cord-022353-q2k2krnm	1490	22	and	and	CC
cord-022353-q2k2krnm	1490	23	human	human	NN
cord-022353-q2k2krnm	1490	24	immunology	immunology	NN
cord-022353-q2k2krnm	1490	25	Veterinary	Veterinary	NNP
cord-022353-q2k2krnm	1490	26	laboratory	laboratory	NN
cord-022353-q2k2krnm	1490	27	medicine	medicine	NN
cord-022353-q2k2krnm	1490	28	:	:	:
cord-022353-q2k2krnm	1491	1	interpretation	interpretation	NN
cord-022353-q2k2krnm	1491	2	and	and	CC
cord-022353-q2k2krnm	1491	3	diagnosis	diagnosis	NN
cord-022353-q2k2krnm	1491	4	Induction	induction	NN
cord-022353-q2k2krnm	1491	5	of	of	IN
cord-022353-q2k2krnm	1491	6	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1491	7	metallothionein	metallothionein	NN
cord-022353-q2k2krnm	1491	8	by	by	IN
cord-022353-q2k2krnm	1491	9	non	non	JJ
cord-022353-q2k2krnm	1491	10	-	-	JJ
cord-022353-q2k2krnm	1491	11	metallic	metallic	JJ
cord-022353-q2k2krnm	1491	12	compounds	compound	NNS
cord-022353-q2k2krnm	1491	13	associated	associate	VBN
cord-022353-q2k2krnm	1491	14	with	with	IN
cord-022353-q2k2krnm	1491	15	the	the	DT
cord-022353-q2k2krnm	1491	16	acute	acute	JJ
cord-022353-q2k2krnm	1491	17	phase	phase	NN
cord-022353-q2k2krnm	1491	18	response	response	NN
cord-022353-q2k2krnm	1491	19	in	in	IN
cord-022353-q2k2krnm	1491	20	inflammation	inflammation	NN
cord-022353-q2k2krnm	1491	21	Clinical	clinical	JJ
cord-022353-q2k2krnm	1491	22	biochemistry	biochemistry	NN
cord-022353-q2k2krnm	1491	23	and	and	CC
cord-022353-q2k2krnm	1491	24	hematological	hematological	JJ
cord-022353-q2k2krnm	1491	25	reference	reference	NN
cord-022353-q2k2krnm	1491	26	values	value	NNS
cord-022353-q2k2krnm	1491	27	in	in	IN
cord-022353-q2k2krnm	1491	28	normal	normal	JJ
cord-022353-q2k2krnm	1491	29	experimental	experimental	JJ
cord-022353-q2k2krnm	1491	30	animals	animal	NNS
cord-022353-q2k2krnm	1491	31	Relationship	relationship	NN
cord-022353-q2k2krnm	1491	32	between	between	IN
cord-022353-q2k2krnm	1491	33	the	the	DT
cord-022353-q2k2krnm	1491	34	development	development	NN
cord-022353-q2k2krnm	1491	35	of	of	IN
cord-022353-q2k2krnm	1491	36	the	the	DT
cord-022353-q2k2krnm	1491	37	intestinal	intestinal	JJ
cord-022353-q2k2krnm	1491	38	IgA	IgA	NNP
cord-022353-q2k2krnm	1491	39	immune	immune	NNP
cord-022353-q2k2krnm	1491	40	system	system	NN
cord-022353-q2k2krnm	1491	41	and	and	CC
cord-022353-q2k2krnm	1491	42	the	the	DT
cord-022353-q2k2krnm	1491	43	establishment	establishment	NN
cord-022353-q2k2krnm	1491	44	of	of	IN
cord-022353-q2k2krnm	1491	45	microbial	microbial	JJ
cord-022353-q2k2krnm	1491	46	flora	flora	NNS
cord-022353-q2k2krnm	1491	47	in	in	IN
cord-022353-q2k2krnm	1491	48	the	the	DT
cord-022353-q2k2krnm	1491	49	digestive	digestive	JJ
cord-022353-q2k2krnm	1491	50	tract	tract	NN
cord-022353-q2k2krnm	1491	51	of	of	IN
cord-022353-q2k2krnm	1491	52	young	young	JJ
cord-022353-q2k2krnm	1491	53	holoxenic	holoxenic	JJ
cord-022353-q2k2krnm	1491	54	mice	mouse	NNS
cord-022353-q2k2krnm	1491	55	Split	Split	NNP
cord-022353-q2k2krnm	1491	56	activity	activity	NN
cord-022353-q2k2krnm	1491	57	of	of	IN
cord-022353-q2k2krnm	1491	58	interleukin-10	interleukin-10	NN
cord-022353-q2k2krnm	1491	59	on	on	IN
cord-022353-q2k2krnm	1491	60	antigen	antigen	NN
cord-022353-q2k2krnm	1491	61	capture	capture	NN
cord-022353-q2k2krnm	1491	62	and	and	CC
cord-022353-q2k2krnm	1491	63	antigen	antigen	NN
cord-022353-q2k2krnm	1491	64	presentation	presentation	NN
cord-022353-q2k2krnm	1491	65	by	by	IN
cord-022353-q2k2krnm	1491	66	human	human	JJ
cord-022353-q2k2krnm	1491	67	dendritic	dendritic	JJ
cord-022353-q2k2krnm	1491	68	cells	cell	NNS
cord-022353-q2k2krnm	1491	69	:	:	:
cord-022353-q2k2krnm	1491	70	definition	definition	NN
cord-022353-q2k2krnm	1491	71	of	of	IN
cord-022353-q2k2krnm	1491	72	a	a	DT
cord-022353-q2k2krnm	1491	73	maturative	maturative	JJ
cord-022353-q2k2krnm	1491	74	step	step	NN
cord-022353-q2k2krnm	1491	75	Genetic	genetic	JJ
cord-022353-q2k2krnm	1491	76	susceptibility	susceptibility	NN
cord-022353-q2k2krnm	1491	77	and	and	CC
cord-022353-q2k2krnm	1491	78	resistance	resistance	NN
cord-022353-q2k2krnm	1491	79	to	to	IN
cord-022353-q2k2krnm	1491	80	diet	diet	NN
cord-022353-q2k2krnm	1491	81	-	-	HYPH
cord-022353-q2k2krnm	1491	82	induced	induce	VBN
cord-022353-q2k2krnm	1491	83	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1491	84	and	and	CC
cord-022353-q2k2krnm	1491	85	hyperlipoproteinemia	hyperlipoproteinemia	NNP
cord-022353-q2k2krnm	1491	86	Chemokines	Chemokines	NNPS
cord-022353-q2k2krnm	1491	87	;	;	:
cord-022353-q2k2krnm	1491	88	multiple	multiple	JJ
cord-022353-q2k2krnm	1491	89	levels	level	NNS
cord-022353-q2k2krnm	1491	90	of	of	IN
cord-022353-q2k2krnm	1491	91	leukocyte	leukocyte	NN
cord-022353-q2k2krnm	1491	92	migration	migration	NN
cord-022353-q2k2krnm	1491	93	control	control	NN
cord-022353-q2k2krnm	1491	94	Initial	initial	JJ
cord-022353-q2k2krnm	1491	95	sequencing	sequencing	NN
cord-022353-q2k2krnm	1491	96	and	and	CC
cord-022353-q2k2krnm	1491	97	comparative	comparative	JJ
cord-022353-q2k2krnm	1491	98	analysis	analysis	NN
cord-022353-q2k2krnm	1491	99	of	of	IN
cord-022353-q2k2krnm	1491	100	the	the	DT
cord-022353-q2k2krnm	1491	101	mouse	mouse	NN
cord-022353-q2k2krnm	1491	102	genome	genome	NN
cord-022353-q2k2krnm	1491	103	Oral	oral	JJ
cord-022353-q2k2krnm	1491	104	tolerance	tolerance	NN
cord-022353-q2k2krnm	1491	105	in	in	IN
cord-022353-q2k2krnm	1491	106	the	the	DT
cord-022353-q2k2krnm	1491	107	absence	absence	NN
cord-022353-q2k2krnm	1491	108	of	of	IN
cord-022353-q2k2krnm	1491	109	naturally	naturally	RB
cord-022353-q2k2krnm	1491	110	occurring	occur	VBG
cord-022353-q2k2krnm	1491	111	Tregs	Tregs	NNP
cord-022353-q2k2krnm	1491	112	Structure	Structure	NNP
cord-022353-q2k2krnm	1491	113	,	,	,
cord-022353-q2k2krnm	1491	114	binding	binding	NN
cord-022353-q2k2krnm	1491	115	,	,	,
cord-022353-q2k2krnm	1491	116	and	and	CC
cord-022353-q2k2krnm	1491	117	antagonists	antagonist	NNS
cord-022353-q2k2krnm	1491	118	in	in	IN
cord-022353-q2k2krnm	1491	119	the	the	DT
cord-022353-q2k2krnm	1491	120	IL-4	IL-4	NNP
cord-022353-q2k2krnm	1491	121	/	/	SYM
cord-022353-q2k2krnm	1491	122	IL-13	IL-13	NNP
cord-022353-q2k2krnm	1491	123	receptor	receptor	NN
cord-022353-q2k2krnm	1491	124	system	system	NN
cord-022353-q2k2krnm	1492	1	Corticotropinreleasing	corticotropinrelease	VBG
cord-022353-q2k2krnm	1492	2	hormone	hormone	NN
cord-022353-q2k2krnm	1492	3	deficiency	deficiency	NN
cord-022353-q2k2krnm	1492	4	reveals	reveal	VBZ
cord-022353-q2k2krnm	1492	5	major	major	JJ
cord-022353-q2k2krnm	1492	6	fetal	fetal	NN
cord-022353-q2k2krnm	1492	7	,	,	,
cord-022353-q2k2krnm	1492	8	but	but	CC
cord-022353-q2k2krnm	1492	9	not	not	RB
cord-022353-q2k2krnm	1492	10	adult	adult	NN
cord-022353-q2k2krnm	1492	11	,	,	,
cord-022353-q2k2krnm	1492	12	glucocorticoid	glucocorticoid	NN
cord-022353-q2k2krnm	1492	13	need	need	VBP
cord-022353-q2k2krnm	1492	14	Diet	diet	NN
cord-022353-q2k2krnm	1492	15	effects	effect	NNS
cord-022353-q2k2krnm	1492	16	on	on	IN
cord-022353-q2k2krnm	1492	17	bone	bone	NN
cord-022353-q2k2krnm	1492	18	mineral	mineral	NN
cord-022353-q2k2krnm	1492	19	density	density	NN
cord-022353-q2k2krnm	1492	20	and	and	CC
cord-022353-q2k2krnm	1492	21	content	content	NN
cord-022353-q2k2krnm	1492	22	,	,	,
cord-022353-q2k2krnm	1492	23	body	body	NN
cord-022353-q2k2krnm	1492	24	composition	composition	NN
cord-022353-q2k2krnm	1492	25	,	,	,
cord-022353-q2k2krnm	1492	26	and	and	CC
cord-022353-q2k2krnm	1492	27	plasma	plasma	NN
cord-022353-q2k2krnm	1492	28	glucose	glucose	NN
cord-022353-q2k2krnm	1492	29	,	,	,
cord-022353-q2k2krnm	1492	30	leptin	leptin	NN
cord-022353-q2k2krnm	1492	31	and	and	CC
cord-022353-q2k2krnm	1492	32	insulin	insulin	NN
cord-022353-q2k2krnm	1492	33	levels	level	NNS
cord-022353-q2k2krnm	1492	34	.	.	.
cord-022353-q2k2krnm	1493	1	MPD	MPD	NNP
cord-022353-q2k2krnm	1493	2	:	:	:
cord-022353-q2k2krnm	1493	3	143	143	CD
cord-022353-q2k2krnm	1493	4	.	.	.
cord-022353-q2k2krnm	1494	1	Mouse	Mouse	NNP
cord-022353-q2k2krnm	1494	2	Phenome	Phenome	NNP
cord-022353-q2k2krnm	1494	3	Database	database	NN
cord-022353-q2k2krnm	1494	4	Web	web	NN
cord-022353-q2k2krnm	1494	5	Site	site	NN
cord-022353-q2k2krnm	1494	6	Evaluation	Evaluation	NNP
cord-022353-q2k2krnm	1494	7	of	of	IN
cord-022353-q2k2krnm	1494	8	H	H	NNP
cord-022353-q2k2krnm	1494	9	-	-	HYPH
cord-022353-q2k2krnm	1494	10	FABP	FABP	NNP
cord-022353-q2k2krnm	1494	11	as	as	IN
cord-022353-q2k2krnm	1494	12	a	a	DT
cord-022353-q2k2krnm	1494	13	marker	marker	NN
cord-022353-q2k2krnm	1494	14	of	of	IN
cord-022353-q2k2krnm	1494	15	ongoing	ongoing	JJ
cord-022353-q2k2krnm	1494	16	myocardial	myocardial	JJ
cord-022353-q2k2krnm	1494	17	damage	damage	NN
cord-022353-q2k2krnm	1494	18	using	use	VBG
cord-022353-q2k2krnm	1494	19	hGH	hGH	NNP
cord-022353-q2k2krnm	1494	20	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1494	21	mice	mouse	NNS
cord-022353-q2k2krnm	1495	1	Lipid	lipid	JJ
cord-022353-q2k2krnm	1495	2	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	1495	3	mediators	mediator	NNS
cord-022353-q2k2krnm	1495	4	in	in	IN
cord-022353-q2k2krnm	1495	5	diabetic	diabetic	JJ
cord-022353-q2k2krnm	1495	6	vascular	vascular	JJ
cord-022353-q2k2krnm	1495	7	disease	disease	NN
cord-022353-q2k2krnm	1495	8	Transgenic	transgenic	JJ
cord-022353-q2k2krnm	1495	9	expression	expression	NN
cord-022353-q2k2krnm	1495	10	of	of	IN
cord-022353-q2k2krnm	1495	11	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	1495	12	secretory	secretory	NN
cord-022353-q2k2krnm	1495	13	trypsin	trypsin	NN
cord-022353-q2k2krnm	1495	14	inhibitor-1	inhibitor-1	NNP
cord-022353-q2k2krnm	1495	15	ameliorates	ameliorate	VBZ
cord-022353-q2k2krnm	1495	16	secretagogue	secretagogue	NN
cord-022353-q2k2krnm	1495	17	-	-	HYPH
cord-022353-q2k2krnm	1495	18	induced	induce	VBN
cord-022353-q2k2krnm	1495	19	pancreatitis	pancreatitis	NN
cord-022353-q2k2krnm	1495	20	in	in	IN
cord-022353-q2k2krnm	1495	21	mice	mouse	NNS
cord-022353-q2k2krnm	1495	22	Summary	Summary	NNP
cord-022353-q2k2krnm	1495	23	of	of	IN
cord-022353-q2k2krnm	1495	24	the	the	DT
cord-022353-q2k2krnm	1495	25	second	second	JJ
cord-022353-q2k2krnm	1495	26	report	report	NN
cord-022353-q2k2krnm	1495	27	of	of	IN
cord-022353-q2k2krnm	1495	28	the	the	DT
cord-022353-q2k2krnm	1495	29	National	National	NNP
cord-022353-q2k2krnm	1495	30	Cholesterol	Cholesterol	NNP
cord-022353-q2k2krnm	1495	31	Education	Education	NNP
cord-022353-q2k2krnm	1495	32	Program	Program	NNP
cord-022353-q2k2krnm	1495	33	(	(	-LRB-
cord-022353-q2k2krnm	1495	34	NCEP	NCEP	NNP
cord-022353-q2k2krnm	1495	35	)	)	-RRB-
cord-022353-q2k2krnm	1495	36	Expert	Expert	NNP
cord-022353-q2k2krnm	1495	37	Panel	Panel	NNP
cord-022353-q2k2krnm	1495	38	on	on	IN
cord-022353-q2k2krnm	1495	39	Detection	Detection	NNP
cord-022353-q2k2krnm	1495	40	,	,	,
cord-022353-q2k2krnm	1495	41	Evaluation	Evaluation	NNP
cord-022353-q2k2krnm	1495	42	,	,	,
cord-022353-q2k2krnm	1495	43	and	and	CC
cord-022353-q2k2krnm	1495	44	Treatment	Treatment	NNP
cord-022353-q2k2krnm	1495	45	of	of	IN
cord-022353-q2k2krnm	1495	46	High	high	JJ
cord-022353-q2k2krnm	1495	47	Blood	blood	NN
cord-022353-q2k2krnm	1495	48	Cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1495	49	in	in	IN
cord-022353-q2k2krnm	1495	50	Adults	Adults	NNP
cord-022353-q2k2krnm	1495	51	Recognition	Recognition	NNP
cord-022353-q2k2krnm	1495	52	and	and	CC
cord-022353-q2k2krnm	1495	53	clearance	clearance	NN
cord-022353-q2k2krnm	1495	54	of	of	IN
cord-022353-q2k2krnm	1495	55	apoptotic	apoptotic	JJ
cord-022353-q2k2krnm	1495	56	cells	cell	NNS
cord-022353-q2k2krnm	1495	57	:	:	:
cord-022353-q2k2krnm	1495	58	a	a	DT
cord-022353-q2k2krnm	1495	59	role	role	NN
cord-022353-q2k2krnm	1495	60	for	for	IN
cord-022353-q2k2krnm	1495	61	complement	complement	NN
cord-022353-q2k2krnm	1495	62	and	and	CC
cord-022353-q2k2krnm	1495	63	pentraxins	pentraxin	NNS
cord-022353-q2k2krnm	1496	1	Mildly	mildly	RB
cord-022353-q2k2krnm	1496	2	oxidized	oxidize	VBN
cord-022353-q2k2krnm	1496	3	LDL	ldl	NN
cord-022353-q2k2krnm	1496	4	induces	induce	VBZ
cord-022353-q2k2krnm	1496	5	an	an	DT
cord-022353-q2k2krnm	1496	6	increase	increase	NN
cord-022353-q2k2krnm	1496	7	apolipoprotein	apolipoprotein	NN
cord-022353-q2k2krnm	1496	8	J	J	NNP
cord-022353-q2k2krnm	1496	9	/	/	SYM
cord-022353-q2k2krnm	1496	10	paraoxonase	paraoxonase	NN
cord-022353-q2k2krnm	1496	11	ration	ration	NN
cord-022353-q2k2krnm	1496	12	The	the	DT
cord-022353-q2k2krnm	1496	13	genetic	genetic	JJ
cord-022353-q2k2krnm	1496	14	control	control	NN
cord-022353-q2k2krnm	1496	15	of	of	IN
cord-022353-q2k2krnm	1496	16	alkaline	alkaline	JJ
cord-022353-q2k2krnm	1496	17	phosphatase	phosphatase	NN
cord-022353-q2k2krnm	1496	18	activity	activity	NN
cord-022353-q2k2krnm	1496	19	in	in	IN
cord-022353-q2k2krnm	1496	20	the	the	DT
cord-022353-q2k2krnm	1496	21	duodenum	duodenum	NN
cord-022353-q2k2krnm	1496	22	of	of	IN
cord-022353-q2k2krnm	1496	23	the	the	DT
cord-022353-q2k2krnm	1496	24	mouse	mouse	NN
cord-022353-q2k2krnm	1496	25	Diabetes	Diabetes	NNP
cord-022353-q2k2krnm	1496	26	mellitus	mellitus	NN
cord-022353-q2k2krnm	1496	27	:	:	:
cord-022353-q2k2krnm	1496	28	a	a	DT
cord-022353-q2k2krnm	1496	29	"	"	``
cord-022353-q2k2krnm	1496	30	thrifty	thrifty	JJ
cord-022353-q2k2krnm	1496	31	"	"	''
cord-022353-q2k2krnm	1496	32	genotype	genotype	NN
cord-022353-q2k2krnm	1496	33	rendered	render	VBN
cord-022353-q2k2krnm	1496	34	detrimental	detrimental	JJ
cord-022353-q2k2krnm	1496	35	by	by	IN
cord-022353-q2k2krnm	1496	36	"	"	``
cord-022353-q2k2krnm	1496	37	progress	progress	NN
cord-022353-q2k2krnm	1496	38	"	"	''
cord-022353-q2k2krnm	1496	39	?	?	.
cord-022353-q2k2krnm	1497	1	CX3CRl	CX3CRl	NNP
cord-022353-q2k2krnm	1497	2	-	-	HYPH
cord-022353-q2k2krnm	1497	3	mediated	mediate	VBN
cord-022353-q2k2krnm	1497	4	dendritic	dendritic	JJ
cord-022353-q2k2krnm	1497	5	cell	cell	NN
cord-022353-q2k2krnm	1497	6	access	access	NN
cord-022353-q2k2krnm	1497	7	to	to	IN
cord-022353-q2k2krnm	1497	8	the	the	DT
cord-022353-q2k2krnm	1497	9	intestinal	intestinal	JJ
cord-022353-q2k2krnm	1497	10	lumen	lumen	NN
cord-022353-q2k2krnm	1497	11	and	and	CC
cord-022353-q2k2krnm	1497	12	bacterial	bacterial	JJ
cord-022353-q2k2krnm	1497	13	clearance	clearance	NN
cord-022353-q2k2krnm	1497	14	Clinical	clinical	JJ
cord-022353-q2k2krnm	1497	15	laboratory	laboratory	NN
cord-022353-q2k2krnm	1497	16	reference	reference	NN
cord-022353-q2k2krnm	1497	17	Sequential	sequential	JJ
cord-022353-q2k2krnm	1497	18	blood	blood	NN
cord-022353-q2k2krnm	1497	19	samples	sample	NNS
cord-022353-q2k2krnm	1497	20	from	from	IN
cord-022353-q2k2krnm	1497	21	the	the	DT
cord-022353-q2k2krnm	1497	22	tail	tail	NN
cord-022353-q2k2krnm	1497	23	vein	vein	NN
cord-022353-q2k2krnm	1497	24	of	of	IN
cord-022353-q2k2krnm	1497	25	rats	rat	NNS
cord-022353-q2k2krnm	1497	26	and	and	CC
cord-022353-q2k2krnm	1497	27	mice	mouse	NNS
cord-022353-q2k2krnm	1497	28	obtained	obtain	VBN
cord-022353-q2k2krnm	1497	29	with	with	IN
cord-022353-q2k2krnm	1497	30	modified	modify	VBN
cord-022353-q2k2krnm	1497	31	Liebig	Liebig	NNP
cord-022353-q2k2krnm	1497	32	condenser	condenser	NN
cord-022353-q2k2krnm	1497	33	jackets	jacket	NNS
cord-022353-q2k2krnm	1497	34	and	and	CC
cord-022353-q2k2krnm	1497	35	vacuum	vacuum	NN
cord-022353-q2k2krnm	1498	1	The	the	DT
cord-022353-q2k2krnm	1498	2	cancer	cancer	NN
cord-022353-q2k2krnm	1498	3	research	research	NN
cord-022353-q2k2krnm	1498	4	UK	UK	NNP
cord-022353-q2k2krnm	1498	5	experience	experience	NN
cord-022353-q2k2krnm	1498	6	of	of	IN
cord-022353-q2k2krnm	1498	7	pre	pre	JJ
cord-022353-q2k2krnm	1498	8	-	-	JJ
cord-022353-q2k2krnm	1498	9	clinical	clinical	JJ
cord-022353-q2k2krnm	1498	10	toxicology	toxicology	NN
cord-022353-q2k2krnm	1498	11	studies	study	NNS
cord-022353-q2k2krnm	1498	12	to	to	TO
cord-022353-q2k2krnm	1498	13	support	support	VB
cord-022353-q2k2krnm	1498	14	early	early	JJ
cord-022353-q2k2krnm	1498	15	clinical	clinical	JJ
cord-022353-q2k2krnm	1498	16	trials	trial	NNS
cord-022353-q2k2krnm	1498	17	with	with	IN
cord-022353-q2k2krnm	1498	18	novel	novel	JJ
cord-022353-q2k2krnm	1498	19	cancer	cancer	NN
cord-022353-q2k2krnm	1498	20	therapies	therapy	NNS
cord-022353-q2k2krnm	1499	1	Lactic	lactic	JJ
cord-022353-q2k2krnm	1499	2	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	1499	3	virus	virus	NN
cord-022353-q2k2krnm	1499	4	Insight	insight	NN
cord-022353-q2k2krnm	1499	5	into	into	IN
cord-022353-q2k2krnm	1499	6	the	the	DT
cord-022353-q2k2krnm	1499	7	physiological	physiological	JJ
cord-022353-q2k2krnm	1499	8	actions	action	NNS
cord-022353-q2k2krnm	1499	9	of	of	IN
cord-022353-q2k2krnm	1499	10	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1499	11	hormone	hormone	NN
cord-022353-q2k2krnm	1499	12	receptors	receptor	NNS
cord-022353-q2k2krnm	1499	13	from	from	IN
cord-022353-q2k2krnm	1500	1	genetically	genetically	RB
cord-022353-q2k2krnm	1500	2	modified	modify	VBN
cord-022353-q2k2krnm	1500	3	mice	mouse	NNS
cord-022353-q2k2krnm	1500	4	CCR7	CCR7	NNP
cord-022353-q2k2krnm	1500	5	governs	govern	VBZ
cord-022353-q2k2krnm	1500	6	skin	skin	NN
cord-022353-q2k2krnm	1500	7	dendritic	dendritic	JJ
cord-022353-q2k2krnm	1500	8	cell	cell	NN
cord-022353-q2k2krnm	1500	9	migration	migration	NN
cord-022353-q2k2krnm	1500	10	under	under	IN
cord-022353-q2k2krnm	1500	11	inflammatory	inflammatory	JJ
cord-022353-q2k2krnm	1500	12	and	and	CC
cord-022353-q2k2krnm	1500	13	steady	steady	JJ
cord-022353-q2k2krnm	1500	14	state	state	NN
cord-022353-q2k2krnm	1500	15	conditions	condition	NNS
cord-022353-q2k2krnm	1500	16	Viral	viral	JJ
cord-022353-q2k2krnm	1500	17	pertubation	pertubation	NN
cord-022353-q2k2krnm	1500	18	of	of	IN
cord-022353-q2k2krnm	1500	19	endocrine	endocrine	JJ
cord-022353-q2k2krnm	1500	20	function	function	NN
cord-022353-q2k2krnm	1500	21	:	:	:
cord-022353-q2k2krnm	1500	22	disordered	disordered	JJ
cord-022353-q2k2krnm	1500	23	cell	cell	NN
cord-022353-q2k2krnm	1500	24	function	function	NN
cord-022353-q2k2krnm	1500	25	leads	lead	VBZ
cord-022353-q2k2krnm	1500	26	to	to	TO
cord-022353-q2k2krnm	1500	27	disturbed	disturbed	VB
cord-022353-q2k2krnm	1500	28	homeostasis	homeostasis	NN
cord-022353-q2k2krnm	1500	29	and	and	CC
cord-022353-q2k2krnm	1500	30	disease	disease	NN
cord-022353-q2k2krnm	1500	31	Targeted	target	VBN
cord-022353-q2k2krnm	1500	32	disruption	disruption	NN
cord-022353-q2k2krnm	1500	33	of	of	IN
cord-022353-q2k2krnm	1500	34	hormone	hormone	NN
cord-022353-q2k2krnm	1500	35	-	-	HYPH
cord-022353-q2k2krnm	1500	36	sensitive	sensitive	JJ
cord-022353-q2k2krnm	1500	37	lipase	lipase	NN
cord-022353-q2k2krnm	1500	38	results	result	NNS
cord-022353-q2k2krnm	1500	39	in	in	IN
cord-022353-q2k2krnm	1500	40	male	male	JJ
cord-022353-q2k2krnm	1500	41	sterility	sterility	NN
cord-022353-q2k2krnm	1500	42	and	and	CC
cord-022353-q2k2krnm	1500	43	adipocyte	adipocyte	NN
cord-022353-q2k2krnm	1500	44	hypertrophy	hypertrophy	NN
cord-022353-q2k2krnm	1500	45	,	,	,
cord-022353-q2k2krnm	1500	46	but	but	CC
cord-022353-q2k2krnm	1500	47	not	not	RB
cord-022353-q2k2krnm	1500	48	in	in	IN
cord-022353-q2k2krnm	1500	49	obesity	obesity	NN
cord-022353-q2k2krnm	1500	50	Genetics	genetic	NNS
cord-022353-q2k2krnm	1500	51	,	,	,
cord-022353-q2k2krnm	1500	52	cytokines	cytokine	NNS
cord-022353-q2k2krnm	1500	53	,	,	,
cord-022353-q2k2krnm	1500	54	and	and	CC
cord-022353-q2k2krnm	1500	55	human	human	JJ
cord-022353-q2k2krnm	1500	56	infectious	infectious	JJ
cord-022353-q2k2krnm	1500	57	disease	disease	NN
cord-022353-q2k2krnm	1500	58	:	:	:
cord-022353-q2k2krnm	1500	59	lessons	lesson	NNS
cord-022353-q2k2krnm	1500	60	from	from	IN
cord-022353-q2k2krnm	1500	61	weekly	weekly	JJ
cord-022353-q2k2krnm	1500	62	pathogenic	pathogenic	JJ
cord-022353-q2k2krnm	1500	63	mycobacteria	mycobacterium	NNS
cord-022353-q2k2krnm	1500	64	and	and	CC
cord-022353-q2k2krnm	1500	65	salmonellae	salmonellae	NNP
cord-022353-q2k2krnm	1500	66	Circadian	circadian	JJ
cord-022353-q2k2krnm	1500	67	rhythms	rhythm	NNS
cord-022353-q2k2krnm	1500	68	of	of	IN
cord-022353-q2k2krnm	1500	69	plasma	plasma	NN
cord-022353-q2k2krnm	1500	70	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1500	71	binding	bind	VBG
cord-022353-q2k2krnm	1500	72	activity	activity	NN
cord-022353-q2k2krnm	1500	73	in	in	IN
cord-022353-q2k2krnm	1500	74	the	the	DT
cord-022353-q2k2krnm	1500	75	rat	rat	NN
cord-022353-q2k2krnm	1500	76	and	and	CC
cord-022353-q2k2krnm	1500	77	mouse	mouse	NN
cord-022353-q2k2krnm	1501	1	One	one	CD
cord-022353-q2k2krnm	1501	2	hundred	hundred	CD
cord-022353-q2k2krnm	1501	3	years	year	NNS
cord-022353-q2k2krnm	1501	4	of	of	IN
cord-022353-q2k2krnm	1501	5	mouse	mouse	NN
cord-022353-q2k2krnm	1501	6	genetics	genetic	NNS
cord-022353-q2k2krnm	1501	7	:	:	:
cord-022353-q2k2krnm	1501	8	an	an	DT
cord-022353-q2k2krnm	1501	9	intellectual	intellectual	JJ
cord-022353-q2k2krnm	1501	10	history	history	NN
cord-022353-q2k2krnm	1501	11	.	.	.
cord-022353-q2k2krnm	1502	1	I.	I.	NNP
cord-022353-q2k2krnm	1503	1	The	the	DT
cord-022353-q2k2krnm	1503	2	classical	classical	JJ
cord-022353-q2k2krnm	1503	3	period	period	NN
cord-022353-q2k2krnm	1504	1	One	one	CD
cord-022353-q2k2krnm	1504	2	hundred	hundred	CD
cord-022353-q2k2krnm	1504	3	years	year	NNS
cord-022353-q2k2krnm	1504	4	of	of	IN
cord-022353-q2k2krnm	1504	5	mouse	mouse	NN
cord-022353-q2k2krnm	1504	6	genetics	genetic	NNS
cord-022353-q2k2krnm	1504	7	:	:	:
cord-022353-q2k2krnm	1504	8	an	an	DT
cord-022353-q2k2krnm	1504	9	intellectual	intellectual	JJ
cord-022353-q2k2krnm	1504	10	history	history	NN
cord-022353-q2k2krnm	1504	11	.	.	.
cord-022353-q2k2krnm	1505	1	II	II	NNP
cord-022353-q2k2krnm	1505	2	.	.	.
cord-022353-q2k2krnm	1506	1	The	the	DT
cord-022353-q2k2krnm	1506	2	molecular	molecular	JJ
cord-022353-q2k2krnm	1506	3	revolution	revolution	NN
cord-022353-q2k2krnm	1507	1	The	the	DT
cord-022353-q2k2krnm	1507	2	ultrastructural	ultrastructural	JJ
cord-022353-q2k2krnm	1507	3	localization	localization	NN
cord-022353-q2k2krnm	1507	4	of	of	IN
cord-022353-q2k2krnm	1507	5	the	the	DT
cord-022353-q2k2krnm	1507	6	isoenzymes	isoenzyme	NNS
cord-022353-q2k2krnm	1507	7	of	of	IN
cord-022353-q2k2krnm	1507	8	aspartate	aspartate	NNP
cord-022353-q2k2krnm	1507	9	aminotransferase	aminotransferase	NN
cord-022353-q2k2krnm	1507	10	in	in	IN
cord-022353-q2k2krnm	1507	11	murine	murine	JJ
cord-022353-q2k2krnm	1507	12	tissues	tissue	NNS
cord-022353-q2k2krnm	1508	1	Proteomic	proteomic	JJ
cord-022353-q2k2krnm	1508	2	analysis	analysis	NN
cord-022353-q2k2krnm	1508	3	of	of	IN
cord-022353-q2k2krnm	1508	4	diet	diet	NN
cord-022353-q2k2krnm	1508	5	-	-	HYPH
cord-022353-q2k2krnm	1508	6	induced	induce	VBN
cord-022353-q2k2krnm	1508	7	hypercholesterolemic	hypercholesterolemic	NNP
cord-022353-q2k2krnm	1508	8	mic	mic	NNP
cord-022353-q2k2krnm	1508	9	Clinical	clinical	JJ
cord-022353-q2k2krnm	1508	10	chemistry	chemistry	NN
cord-022353-q2k2krnm	1508	11	values	value	NNS
cord-022353-q2k2krnm	1508	12	of	of	IN
cord-022353-q2k2krnm	1508	13	the	the	DT
cord-022353-q2k2krnm	1508	14	N	n	CD
cord-022353-q2k2krnm	1509	1	:	:	:
cord-022353-q2k2krnm	1509	2	NIH(S	nih(s	LS
cord-022353-q2k2krnm	1509	3	)	)	-RRB-
cord-022353-q2k2krnm	1509	4	mice	mouse	NNS
cord-022353-q2k2krnm	1509	5	and	and	CC
cord-022353-q2k2krnm	1509	6	parameter	parameter	NN
cord-022353-q2k2krnm	1509	7	variations	variation	NNS
cord-022353-q2k2krnm	1509	8	due	due	JJ
cord-022353-q2k2krnm	1509	9	to	to	IN
cord-022353-q2k2krnm	1509	10	sampling	sampling	NN
cord-022353-q2k2krnm	1509	11	techniques	technique	NNS
cord-022353-q2k2krnm	1509	12	Use	use	VB
cord-022353-q2k2krnm	1509	13	of	of	IN
cord-022353-q2k2krnm	1509	14	proteomic	proteomic	JJ
cord-022353-q2k2krnm	1509	15	patterns	pattern	NNS
cord-022353-q2k2krnm	1509	16	in	in	IN
cord-022353-q2k2krnm	1509	17	serum	serum	NN
cord-022353-q2k2krnm	1509	18	to	to	TO
cord-022353-q2k2krnm	1509	19	identify	identify	VB
cord-022353-q2k2krnm	1509	20	ovarian	ovarian	JJ
cord-022353-q2k2krnm	1509	21	cancer	cancer	NN
cord-022353-q2k2krnm	1509	22	Lessons	lesson	NNS
cord-022353-q2k2krnm	1509	23	from	from	IN
cord-022353-q2k2krnm	1509	24	Kitty	Kitty	NNP
cord-022353-q2k2krnm	1509	25	Hawk	Hawk	NNP
cord-022353-q2k2krnm	1509	26	:	:	:
cord-022353-q2k2krnm	1509	27	from	from	IN
cord-022353-q2k2krnm	1509	28	feasibility	feasibility	NN
cord-022353-q2k2krnm	1509	29	to	to	IN
cord-022353-q2k2krnm	1509	30	routine	routine	JJ
cord-022353-q2k2krnm	1509	31	clinical	clinical	JJ
cord-022353-q2k2krnm	1509	32	use	use	NN
cord-022353-q2k2krnm	1509	33	for	for	IN
cord-022353-q2k2krnm	1509	34	the	the	DT
cord-022353-q2k2krnm	1509	35	field	field	NN
cord-022353-q2k2krnm	1509	36	of	of	IN
cord-022353-q2k2krnm	1509	37	proteomic	proteomic	JJ
cord-022353-q2k2krnm	1509	38	pattern	pattern	NN
cord-022353-q2k2krnm	1509	39	diagnostics	diagnostic	VBZ
cord-022353-q2k2krnm	1509	40	Alkaline	alkaline	JJ
cord-022353-q2k2krnm	1509	41	phosphatase	phosphatase	NN
cord-022353-q2k2krnm	1509	42	activity	activity	NN
cord-022353-q2k2krnm	1509	43	of	of	IN
cord-022353-q2k2krnm	1509	44	the	the	DT
cord-022353-q2k2krnm	1509	45	mouse	mouse	NN
cord-022353-q2k2krnm	1509	46	Immune	Immune	NNP
cord-022353-q2k2krnm	1509	47	regulation	regulation	NN
cord-022353-q2k2krnm	1509	48	in	in	IN
cord-022353-q2k2krnm	1509	49	the	the	DT
cord-022353-q2k2krnm	1509	50	intestine	intestine	NN
cord-022353-q2k2krnm	1509	51	Boosted	boost	VBN
cord-022353-q2k2krnm	1509	52	decision	decision	NN
cord-022353-q2k2krnm	1509	53	tree	tree	NN
cord-022353-q2k2krnm	1509	54	analysis	analysis	NN
cord-022353-q2k2krnm	1509	55	of	of	IN
cord-022353-q2k2krnm	1509	56	surface	surface	NN
cord-022353-q2k2krnm	1509	57	enhanced	enhance	VBN
cord-022353-q2k2krnm	1509	58	laser	laser	NN
cord-022353-q2k2krnm	1509	59	desorption	desorption	NN
cord-022353-q2k2krnm	1509	60	/	/	SYM
cord-022353-q2k2krnm	1509	61	ionization	ionization	NN
cord-022353-q2k2krnm	1509	62	mass	mass	JJ
cord-022353-q2k2krnm	1509	63	spectral	spectral	JJ
cord-022353-q2k2krnm	1509	64	serum	serum	NN
cord-022353-q2k2krnm	1509	65	profiles	profile	NNS
cord-022353-q2k2krnm	1509	66	discriminates	discriminate	VBZ
cord-022353-q2k2krnm	1509	67	prostate	prostate	NN
cord-022353-q2k2krnm	1509	68	cancer	cancer	NN
cord-022353-q2k2krnm	1509	69	from	from	IN
cord-022353-q2k2krnm	1509	70	non	non	JJ
cord-022353-q2k2krnm	1509	71	-	-	JJ
cord-022353-q2k2krnm	1509	72	cancer	cancer	JJ
cord-022353-q2k2krnm	1509	73	patients	patient	NNS
cord-022353-q2k2krnm	1509	74	Animal	Animal	NNP
cord-022353-q2k2krnm	1509	75	models	model	NNS
cord-022353-q2k2krnm	1509	76	in	in	IN
cord-022353-q2k2krnm	1509	77	biomedical	biomedical	JJ
cord-022353-q2k2krnm	1509	78	research	research	NN
cord-022353-q2k2krnm	1509	79	Complement	Complement	NNP
cord-022353-q2k2krnm	1509	80	The	the	DT
cord-022353-q2k2krnm	1509	81	mouse	mouse	NN
cord-022353-q2k2krnm	1509	82	Transgenic	transgenic	JJ
cord-022353-q2k2krnm	1509	83	models	model	NNS
cord-022353-q2k2krnm	1509	84	of	of	IN
cord-022353-q2k2krnm	1509	85	tolerance	tolerance	NN
cord-022353-q2k2krnm	1509	86	and	and	CC
cord-022353-q2k2krnm	1509	87	autoimmunity	autoimmunity	NN
cord-022353-q2k2krnm	1509	88	:	:	:
cord-022353-q2k2krnm	1509	89	with	with	IN
cord-022353-q2k2krnm	1509	90	special	special	JJ
cord-022353-q2k2krnm	1509	91	reference	reference	NN
cord-022353-q2k2krnm	1509	92	to	to	IN
cord-022353-q2k2krnm	1509	93	systemic	systemic	JJ
cord-022353-q2k2krnm	1509	94	lupus	lupus	NN
cord-022353-q2k2krnm	1509	95	erythematosus	erythematosus	NN
cord-022353-q2k2krnm	1509	96	Short	short	JJ
cord-022353-q2k2krnm	1509	97	-	-	HYPH
cord-022353-q2k2krnm	1509	98	term	term	NN
cord-022353-q2k2krnm	1509	99	and	and	CC
cord-022353-q2k2krnm	1509	100	long	long	JJ
cord-022353-q2k2krnm	1509	101	-	-	HYPH
cord-022353-q2k2krnm	1509	102	term	term	NN
cord-022353-q2k2krnm	1509	103	in	in	IN
cord-022353-q2k2krnm	1509	104	vivo	vivo	NN
cord-022353-q2k2krnm	1509	105	exposure	exposure	NN
cord-022353-q2k2krnm	1509	106	to	to	IN
cord-022353-q2k2krnm	1509	107	an	an	DT
cord-022353-q2k2krnm	1509	108	ephedra	ephedra	NN
cord-022353-q2k2krnm	1509	109	-	-	HYPH
cord-022353-q2k2krnm	1509	110	and	and	CC
cord-022353-q2k2krnm	1509	111	caffeine	caffeine	NN
cord-022353-q2k2krnm	1509	112	-	-	HYPH
cord-022353-q2k2krnm	1509	113	containing	contain	VBG
cord-022353-q2k2krnm	1509	114	metabolic	metabolic	JJ
cord-022353-q2k2krnm	1509	115	nutrition	nutrition	NN
cord-022353-q2k2krnm	1509	116	system	system	NN
cord-022353-q2k2krnm	1509	117	does	do	VBZ
cord-022353-q2k2krnm	1509	118	not	not	RB
cord-022353-q2k2krnm	1509	119	induce	induce	VB
cord-022353-q2k2krnm	1509	120	cardiotoxicity	cardiotoxicity	NN
cord-022353-q2k2krnm	1509	121	in	in	IN
cord-022353-q2k2krnm	1509	122	B6C3F1	B6C3F1	NNP
cord-022353-q2k2krnm	1509	123	mice	mouse	NNS
cord-022353-q2k2krnm	1509	124	Model	Model	NNP
cord-022353-q2k2krnm	1509	125	models	model	NNS
cord-022353-q2k2krnm	1509	126	of	of	IN
cord-022353-q2k2krnm	1509	127	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1509	128	Hormones	hormone	NNS
cord-022353-q2k2krnm	1509	129	Type	Type	NNP
cord-022353-q2k2krnm	1509	130	2	2	CD
cord-022353-q2k2krnm	1509	131	diabetes	diabetes	NN
cord-022353-q2k2krnm	1509	132	:	:	:
cord-022353-q2k2krnm	1509	133	a	a	DT
cord-022353-q2k2krnm	1509	134	matter	matter	NN
cord-022353-q2k2krnm	1509	135	of	of	IN
cord-022353-q2k2krnm	1509	136	beta	beta	JJ
cord-022353-q2k2krnm	1509	137	-	-	HYPH
cord-022353-q2k2krnm	1509	138	cell	cell	NN
cord-022353-q2k2krnm	1509	139	life	life	NN
cord-022353-q2k2krnm	1509	140	and	and	CC
cord-022353-q2k2krnm	1509	141	death	death	NN
cord-022353-q2k2krnm	1509	142	Leukemia	leukemia	NN
cord-022353-q2k2krnm	1509	143	inhibitory	inhibitory	JJ
cord-022353-q2k2krnm	1509	144	factor	factor	NN
cord-022353-q2k2krnm	1509	145	and	and	CC
cord-022353-q2k2krnm	1509	146	interleukin	interleukin	NN
cord-022353-q2k2krnm	1509	147	-	-	HYPH
cord-022353-q2k2krnm	1509	148	ll	ll	NN
cord-022353-q2k2krnm	1509	149	:	:	:
cord-022353-q2k2krnm	1509	150	cytokines	cytokine	NNS
cord-022353-q2k2krnm	1509	151	with	with	IN
cord-022353-q2k2krnm	1509	152	key	key	JJ
cord-022353-q2k2krnm	1509	153	roles	role	NNS
cord-022353-q2k2krnm	1509	154	in	in	IN
cord-022353-q2k2krnm	1509	155	implantation	implantation	NN
cord-022353-q2k2krnm	1509	156	Virus	virus	NN
cord-022353-q2k2krnm	1509	157	induced	induce	VBD
cord-022353-q2k2krnm	1509	158	pancreatic	pancreatic	JJ
cord-022353-q2k2krnm	1509	159	disease	disease	NN
cord-022353-q2k2krnm	1509	160	;	;	:
cord-022353-q2k2krnm	1509	161	alterations	alteration	NNS
cord-022353-q2k2krnm	1509	162	in	in	IN
cord-022353-q2k2krnm	1509	163	concentrations	concentration	NNS
cord-022353-q2k2krnm	1509	164	of	of	IN
cord-022353-q2k2krnm	1509	165	glucose	glucose	NN
cord-022353-q2k2krnm	1509	166	and	and	CC
cord-022353-q2k2krnm	1509	167	amylase	amylase	NN
cord-022353-q2k2krnm	1509	168	in	in	IN
cord-022353-q2k2krnm	1509	169	blood	blood	NN
cord-022353-q2k2krnm	1509	170	Lungkine	Lungkine	NNP
cord-022353-q2k2krnm	1509	171	,	,	,
cord-022353-q2k2krnm	1509	172	a	a	DT
cord-022353-q2k2krnm	1509	173	novel	novel	JJ
cord-022353-q2k2krnm	1509	174	CXC	CXC	NNP
cord-022353-q2k2krnm	1509	175	chemokine	chemokine	NN
cord-022353-q2k2krnm	1509	176	,	,	,
cord-022353-q2k2krnm	1509	177	specifically	specifically	RB
cord-022353-q2k2krnm	1509	178	expressed	express	VBN
cord-022353-q2k2krnm	1509	179	by	by	IN
cord-022353-q2k2krnm	1509	180	lung	lung	NN
cord-022353-q2k2krnm	1509	181	bronchoepithelial	bronchoepithelial	NNP
cord-022353-q2k2krnm	1509	182	cells	cell	NNS
cord-022353-q2k2krnm	1509	183	Changes	change	NNS
cord-022353-q2k2krnm	1509	184	in	in	IN
cord-022353-q2k2krnm	1509	185	serum	serum	NN
cord-022353-q2k2krnm	1509	186	hormone	hormone	NN
cord-022353-q2k2krnm	1509	187	levels	level	NNS
cord-022353-q2k2krnm	1509	188	associated	associate	VBN
cord-022353-q2k2krnm	1509	189	with	with	IN
cord-022353-q2k2krnm	1509	190	male	male	NN
cord-022353-q2k2krnm	1509	191	-	-	HYPH
cord-022353-q2k2krnm	1509	192	induced	induce	VBN
cord-022353-q2k2krnm	1509	193	ovulation	ovulation	NN
cord-022353-q2k2krnm	1509	194	in	in	IN
cord-022353-q2k2krnm	1509	195	group	group	NN
cord-022353-q2k2krnm	1509	196	housed	house	VBD
cord-022353-q2k2krnm	1509	197	adult	adult	NN
cord-022353-q2k2krnm	1509	198	female	female	JJ
cord-022353-q2k2krnm	1509	199	mice	mouse	NNS
cord-022353-q2k2krnm	1509	200	KO	KO	NNP
cord-022353-q2k2krnm	1509	201	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1509	202	mouse	mouse	NN
cord-022353-q2k2krnm	1509	203	model	model	NN
cord-022353-q2k2krnm	1509	204	of	of	IN
cord-022353-q2k2krnm	1509	205	sickle	sickle	NN
cord-022353-q2k2krnm	1509	206	cell	cell	NN
cord-022353-q2k2krnm	1509	207	disease	disease	NN
cord-022353-q2k2krnm	1509	208	Animal	Animal	NNP
cord-022353-q2k2krnm	1509	209	models	model	NNS
cord-022353-q2k2krnm	1509	210	of	of	IN
cord-022353-q2k2krnm	1509	211	autoimmunity	autoimmunity	NN
cord-022353-q2k2krnm	1509	212	and	and	CC
cord-022353-q2k2krnm	1509	213	their	-PRON-	PRP$
cord-022353-q2k2krnm	1509	214	relevance	relevance	NN
cord-022353-q2k2krnm	1509	215	to	to	IN
cord-022353-q2k2krnm	1509	216	human	human	JJ
cord-022353-q2k2krnm	1509	217	diseases	disease	NNS
cord-022353-q2k2krnm	1510	1	Hematological	Hematological	NNP
cord-022353-q2k2krnm	1510	2	comparison	comparison	NN
cord-022353-q2k2krnm	1510	3	of	of	IN
cord-022353-q2k2krnm	1510	4	the	the	DT
cord-022353-q2k2krnm	1510	5	mouse	mouse	NN
cord-022353-q2k2krnm	1510	6	blood	blood	NN
cord-022353-q2k2krnm	1510	7	taken	take	VBN
cord-022353-q2k2krnm	1510	8	from	from	IN
cord-022353-q2k2krnm	1510	9	the	the	DT
cord-022353-q2k2krnm	1510	10	eye	eye	NN
cord-022353-q2k2krnm	1510	11	and	and	CC
cord-022353-q2k2krnm	1510	12	tail	tail	NN
cord-022353-q2k2krnm	1510	13	Cystatin	Cystatin	NNP
cord-022353-q2k2krnm	1510	14	C	C	NNP
cord-022353-q2k2krnm	1510	15	as	as	IN
cord-022353-q2k2krnm	1510	16	a	a	DT
cord-022353-q2k2krnm	1510	17	potential	potential	JJ
cord-022353-q2k2krnm	1510	18	cerebrospinal	cerebrospinal	JJ
cord-022353-q2k2krnm	1510	19	fluid	fluid	NN
cord-022353-q2k2krnm	1510	20	marker	marker	NN
cord-022353-q2k2krnm	1510	21	for	for	IN
cord-022353-q2k2krnm	1510	22	the	the	DT
cord-022353-q2k2krnm	1510	23	diagnosis	diagnosis	NN
cord-022353-q2k2krnm	1510	24	of	of	IN
cord-022353-q2k2krnm	1510	25	Creutzfeldt	Creutzfeldt	NNP
cord-022353-q2k2krnm	1510	26	-	-	HYPH
cord-022353-q2k2krnm	1510	27	Jakob	Jakob	NNP
cord-022353-q2k2krnm	1510	28	disease	disease	NN
cord-022353-q2k2krnm	1510	29	Efficacy	Efficacy	NNP
cord-022353-q2k2krnm	1510	30	of	of	IN
cord-022353-q2k2krnm	1510	31	2	2	CD
cord-022353-q2k2krnm	1510	32	,	,	,
cord-022353-q2k2krnm	1510	33	3-dimercapto	3-dimercapto	CD
cord-022353-q2k2krnm	1510	34	-	-	HYPH
cord-022353-q2k2krnm	1510	35	l	l	NN
cord-022353-q2k2krnm	1510	36	-	-	HYPH
cord-022353-q2k2krnm	1510	37	propanesulfonic	propanesulfonic	NNP
cord-022353-q2k2krnm	1510	38	acid	acid	NN
cord-022353-q2k2krnm	1510	39	(	(	-LRB-
cord-022353-q2k2krnm	1510	40	DMPS	DMPS	NNP
cord-022353-q2k2krnm	1510	41	)	)	-RRB-
cord-022353-q2k2krnm	1510	42	and	and	CC
cord-022353-q2k2krnm	1510	43	diphenyl	diphenyl	NNP
cord-022353-q2k2krnm	1510	44	diselenide	diselenide	NNP
cord-022353-q2k2krnm	1510	45	on	on	IN
cord-022353-q2k2krnm	1510	46	cadmium	cadmium	NN
cord-022353-q2k2krnm	1510	47	induced	induce	VBN
cord-022353-q2k2krnm	1510	48	testicular	testicular	JJ
cord-022353-q2k2krnm	1510	49	damage	damage	NN
cord-022353-q2k2krnm	1510	50	in	in	IN
cord-022353-q2k2krnm	1510	51	mice	mouse	NNS
cord-022353-q2k2krnm	1510	52	Multimeric	Multimeric	NNP
cord-022353-q2k2krnm	1510	53	cytokine	cytokine	NN
cord-022353-q2k2krnm	1510	54	receptors	receptor	NNS
cord-022353-q2k2krnm	1510	55	:	:	:
cord-022353-q2k2krnm	1510	56	common	common	JJ
cord-022353-q2k2krnm	1510	57	versus	versus	IN
cord-022353-q2k2krnm	1510	58	specific	specific	JJ
cord-022353-q2k2krnm	1510	59	functions	function	NNS
cord-022353-q2k2krnm	1510	60	Bilateral	bilateral	JJ
cord-022353-q2k2krnm	1510	61	lesions	lesion	NNS
cord-022353-q2k2krnm	1510	62	in	in	IN
cord-022353-q2k2krnm	1510	63	the	the	DT
cord-022353-q2k2krnm	1510	64	suprachiasmatic	suprachiasmatic	NN
cord-022353-q2k2krnm	1510	65	nuclei	nucleus	NNS
cord-022353-q2k2krnm	1510	66	affect	affect	VBP
cord-022353-q2k2krnm	1510	67	circadian	circadian	NN
cord-022353-q2k2krnm	1510	68	rhythms	rhythm	NNS
cord-022353-q2k2krnm	1510	69	and	and	CC
cord-022353-q2k2krnm	1510	70	H	h	NN
cord-022353-q2k2krnm	1510	71	-	-	HYPH
cord-022353-q2k2krnm	1510	72	thymidine	thymidine	JJ
cord-022353-q2k2krnm	1510	73	incorporation	incorporation	NN
cord-022353-q2k2krnm	1510	74	into	into	IN
cord-022353-q2k2krnm	1510	75	deoxyribonucleic	deoxyribonucleic	JJ
cord-022353-q2k2krnm	1510	76	acid	acid	NN
cord-022353-q2k2krnm	1510	77	in	in	IN
cord-022353-q2k2krnm	1510	78	mouse	mouse	NN
cord-022353-q2k2krnm	1510	79	intestinal	intestinal	JJ
cord-022353-q2k2krnm	1510	80	tract	tract	NN
cord-022353-q2k2krnm	1510	81	,	,	,
cord-022353-q2k2krnm	1510	82	mitotic	mitotic	JJ
cord-022353-q2k2krnm	1510	83	index	index	NN
cord-022353-q2k2krnm	1510	84	of	of	IN
cord-022353-q2k2krnm	1510	85	corneal	corneal	JJ
cord-022353-q2k2krnm	1510	86	epithelium	epithelium	NN
cord-022353-q2k2krnm	1510	87	,	,	,
cord-022353-q2k2krnm	1510	88	and	and	CC
cord-022353-q2k2krnm	1510	89	serum	serum	NN
cord-022353-q2k2krnm	1510	90	corticosterone	corticosterone	NN
cord-022353-q2k2krnm	1511	1	PTHrP	PTHrP	NNP
cord-022353-q2k2krnm	1511	2	,	,	,
cord-022353-q2k2krnm	1511	3	PTH	PTH	NNP
cord-022353-q2k2krnm	1511	4	,	,	,
cord-022353-q2k2krnm	1511	5	and	and	CC
cord-022353-q2k2krnm	1511	6	the	the	DT
cord-022353-q2k2krnm	1511	7	PTH	PTH	NNP
cord-022353-q2k2krnm	1511	8	/	/	SYM
cord-022353-q2k2krnm	1511	9	PTHrP	PTHrP	NNP
cord-022353-q2k2krnm	1511	10	receptor	receptor	NN
cord-022353-q2k2krnm	1511	11	in	in	IN
cord-022353-q2k2krnm	1511	12	endochondral	endochondral	JJ
cord-022353-q2k2krnm	1511	13	bone	bone	NN
cord-022353-q2k2krnm	1511	14	development	development	NN
cord-022353-q2k2krnm	1511	15	Diabetes	diabetes	NN
cord-022353-q2k2krnm	1511	16	,	,	,
cord-022353-q2k2krnm	1511	17	obesity	obesity	NN
cord-022353-q2k2krnm	1511	18	,	,	,
cord-022353-q2k2krnm	1511	19	and	and	CC
cord-022353-q2k2krnm	1511	20	the	the	DT
cord-022353-q2k2krnm	1511	21	brain	brain	NN
cord-022353-q2k2krnm	1511	22	Hematopoietic	Hematopoietic	NNP
cord-022353-q2k2krnm	1511	23	,	,	,
cord-022353-q2k2krnm	1511	24	immunomodulatory	immunomodulatory	JJ
cord-022353-q2k2krnm	1511	25	and	and	CC
cord-022353-q2k2krnm	1511	26	epithelial	epithelial	JJ
cord-022353-q2k2krnm	1511	27	effects	effect	NNS
cord-022353-q2k2krnm	1511	28	of	of	IN
cord-022353-q2k2krnm	1511	29	interleukin-11	interleukin-11	CD
cord-022353-q2k2krnm	1511	30	Intestinal	intestinal	JJ
cord-022353-q2k2krnm	1511	31	TSH	TSH	NNP
cord-022353-q2k2krnm	1511	32	production	production	NN
cord-022353-q2k2krnm	1511	33	is	be	VBZ
cord-022353-q2k2krnm	1511	34	localized	localize	VBN
cord-022353-q2k2krnm	1511	35	in	in	IN
cord-022353-q2k2krnm	1511	36	crypt	crypt	JJ
cord-022353-q2k2krnm	1511	37	enterocytes	enterocyte	NNS
cord-022353-q2k2krnm	1511	38	and	and	CC
cord-022353-q2k2krnm	1511	39	in	in	IN
cord-022353-q2k2krnm	1511	40	villus	villus	NNP
cord-022353-q2k2krnm	1511	41	'	'	``
cord-022353-q2k2krnm	1511	42	hotblocks	hotblock	NNS
cord-022353-q2k2krnm	1511	43	'	'	''
cord-022353-q2k2krnm	1511	44	and	and	CC
cord-022353-q2k2krnm	1511	45	is	be	VBZ
cord-022353-q2k2krnm	1511	46	coupled	couple	VBN
cord-022353-q2k2krnm	1511	47	to	to	IN
cord-022353-q2k2krnm	1511	48	IL-7	IL-7	NNP
cord-022353-q2k2krnm	1511	49	production	production	NN
cord-022353-q2k2krnm	1511	50	:	:	:
cord-022353-q2k2krnm	1511	51	evidence	evidence	NN
cord-022353-q2k2krnm	1511	52	for	for	IN
cord-022353-q2k2krnm	1511	53	involvement	involvement	NN
cord-022353-q2k2krnm	1511	54	of	of	IN
cord-022353-q2k2krnm	1511	55	TSH	TSH	NNP
cord-022353-q2k2krnm	1511	56	during	during	IN
cord-022353-q2k2krnm	1511	57	acute	acute	JJ
cord-022353-q2k2krnm	1511	58	enteric	enteric	JJ
cord-022353-q2k2krnm	1511	59	virus	virus	NN
cord-022353-q2k2krnm	1511	60	infection	infection	NN
cord-022353-q2k2krnm	1511	61	Adipsin	Adipsin	NNP
cord-022353-q2k2krnm	1511	62	,	,	,
cord-022353-q2k2krnm	1511	63	a	a	DT
cord-022353-q2k2krnm	1511	64	biomarker	biomarker	NN
cord-022353-q2k2krnm	1511	65	of	of	IN
cord-022353-q2k2krnm	1511	66	gastrointestinal	gastrointestinal	JJ
cord-022353-q2k2krnm	1511	67	toxicity	toxicity	NN
cord-022353-q2k2krnm	1511	68	mediated	mediate	VBN
cord-022353-q2k2krnm	1511	69	by	by	IN
cord-022353-q2k2krnm	1511	70	a	a	DT
cord-022353-q2k2krnm	1511	71	functional	functional	JJ
cord-022353-q2k2krnm	1511	72	gamma	gamma	NN
cord-022353-q2k2krnm	1511	73	-	-	HYPH
cord-022353-q2k2krnm	1511	74	secretase	secretase	JJ
cord-022353-q2k2krnm	1511	75	inhibitor	inhibitor	NN
cord-022353-q2k2krnm	1511	76	Loci	Loci	NNP
cord-022353-q2k2krnm	1511	77	controlling	control	VBG
cord-022353-q2k2krnm	1511	78	plasma	plasma	NN
cord-022353-q2k2krnm	1511	79	non	non	JJ
cord-022353-q2k2krnm	1511	80	-	-	JJ
cord-022353-q2k2krnm	1511	81	HDL	hdl	JJ
cord-022353-q2k2krnm	1511	82	and	and	CC
cord-022353-q2k2krnm	1511	83	HDL	HDL	NNP
cord-022353-q2k2krnm	1511	84	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1511	85	levels	level	NNS
cord-022353-q2k2krnm	1511	86	in	in	IN
cord-022353-q2k2krnm	1511	87	a	a	DT
cord-022353-q2k2krnm	1511	88	C57BL/6J	C57BL/6J	NNP
cord-022353-q2k2krnm	1511	89	x	x	SYM
cord-022353-q2k2krnm	1511	90	CASA	CASA	NNP
cord-022353-q2k2krnm	1511	91	/	/	SYM
cord-022353-q2k2krnm	1511	92	Rk	Rk	NNP
cord-022353-q2k2krnm	1511	93	intercross	intercross	NNP
cord-022353-q2k2krnm	1511	94	Quantitative	quantitative	JJ
cord-022353-q2k2krnm	1511	95	trait	trait	NN
cord-022353-q2k2krnm	1511	96	loci	locus	NNS
cord-022353-q2k2krnm	1511	97	mapping	mapping	NN
cord-022353-q2k2krnm	1511	98	of	of	IN
cord-022353-q2k2krnm	1511	99	genetic	genetic	JJ
cord-022353-q2k2krnm	1511	100	modifiers	modifier	NNS
cord-022353-q2k2krnm	1511	101	of	of	IN
cord-022353-q2k2krnm	1511	102	metabolic	metabolic	JJ
cord-022353-q2k2krnm	1511	103	syndrome	syndrome	NN
cord-022353-q2k2krnm	1511	104	and	and	CC
cord-022353-q2k2krnm	1511	105	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1511	106	in	in	IN
cord-022353-q2k2krnm	1511	107	low	low	JJ
cord-022353-q2k2krnm	1511	108	-	-	HYPH
cord-022353-q2k2krnm	1511	109	density	density	NN
cord-022353-q2k2krnm	1511	110	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	1511	111	receptor	receptor	NN
cord-022353-q2k2krnm	1511	112	-	-	HYPH
cord-022353-q2k2krnm	1511	113	deficient	deficient	JJ
cord-022353-q2k2krnm	1511	114	mice	mouse	NNS
cord-022353-q2k2krnm	1512	1	The	the	DT
cord-022353-q2k2krnm	1512	2	kinase	kinase	NN
cord-022353-q2k2krnm	1512	3	LKB	LKB	NNP
cord-022353-q2k2krnm	1512	4	1	1	CD
cord-022353-q2k2krnm	1512	5	mediates	mediate	VBZ
cord-022353-q2k2krnm	1512	6	glucose	glucose	NN
cord-022353-q2k2krnm	1512	7	homeostasis	homeostasis	NN
cord-022353-q2k2krnm	1512	8	in	in	IN
cord-022353-q2k2krnm	1512	9	liver	liver	NN
cord-022353-q2k2krnm	1512	10	and	and	CC
cord-022353-q2k2krnm	1512	11	therapeutic	therapeutic	JJ
cord-022353-q2k2krnm	1512	12	effects	effect	NNS
cord-022353-q2k2krnm	1512	13	of	of	IN
cord-022353-q2k2krnm	1512	14	metformin	metformin	NNP
cord-022353-q2k2krnm	1512	15	Genetic	genetic	JJ
cord-022353-q2k2krnm	1512	16	defects	defect	NNS
cord-022353-q2k2krnm	1512	17	in	in	IN
cord-022353-q2k2krnm	1512	18	copper	copper	NN
cord-022353-q2k2krnm	1512	19	metabolism	metabolism	NN
cord-022353-q2k2krnm	1512	20	Estrogen	estrogen	NN
cord-022353-q2k2krnm	1512	21	:	:	:
cord-022353-q2k2krnm	1513	1	the	the	DT
cord-022353-q2k2krnm	1513	2	good	good	NN
cord-022353-q2k2krnm	1513	3	,	,	,
cord-022353-q2k2krnm	1513	4	the	the	DT
cord-022353-q2k2krnm	1513	5	bad	bad	JJ
cord-022353-q2k2krnm	1513	6	,	,	,
cord-022353-q2k2krnm	1513	7	and	and	CC
cord-022353-q2k2krnm	1513	8	the	the	DT
cord-022353-q2k2krnm	1513	9	unexpected	unexpected	JJ
cord-022353-q2k2krnm	1513	10	IL-1	IL-1	NNP
cord-022353-q2k2krnm	1513	11	and	and	CC
cord-022353-q2k2krnm	1513	12	IL-18	IL-18	NNP
cord-022353-q2k2krnm	1513	13	receptors	receptor	NNS
cord-022353-q2k2krnm	1513	14	,	,	,
cord-022353-q2k2krnm	1513	15	and	and	CC
cord-022353-q2k2krnm	1513	16	their	-PRON-	PRP$
cord-022353-q2k2krnm	1513	17	extended	extended	JJ
cord-022353-q2k2krnm	1513	18	family	family	NN
cord-022353-q2k2krnm	1513	19	B	b	NN
cord-022353-q2k2krnm	1513	20	-	-	HYPH
cord-022353-q2k2krnm	1513	21	cell	cell	NN
cord-022353-q2k2krnm	1513	22	-	-	HYPH
cord-022353-q2k2krnm	1513	23	and	and	CC
cord-022353-q2k2krnm	1513	24	monocyte	monocyte	NNP
cord-022353-q2k2krnm	1513	25	-	-	HYPH
cord-022353-q2k2krnm	1513	26	activating	activate	VBG
cord-022353-q2k2krnm	1513	27	chemokine	chemokine	NN
cord-022353-q2k2krnm	1513	28	(	(	-LRB-
cord-022353-q2k2krnm	1513	29	BMAC	BMAC	NNP
cord-022353-q2k2krnm	1513	30	)	)	-RRB-
cord-022353-q2k2krnm	1513	31	,	,	,
cord-022353-q2k2krnm	1513	32	a	a	DT
cord-022353-q2k2krnm	1513	33	novel	novel	JJ
cord-022353-q2k2krnm	1513	34	non	non	JJ
cord-022353-q2k2krnm	1513	35	-	-	JJ
cord-022353-q2k2krnm	1513	36	ELR	ELR	NNP
cord-022353-q2k2krnm	1513	37	ct	ct	NNP
cord-022353-q2k2krnm	1513	38	-	-	HYPH
cord-022353-q2k2krnm	1513	39	chemokine	chemokine	NNP
cord-022353-q2k2krnm	1513	40	Feed	feed	NN
cord-022353-q2k2krnm	1513	41	-	-	HYPH
cord-022353-q2k2krnm	1513	42	forward	forward	NN
cord-022353-q2k2krnm	1513	43	regulation	regulation	NN
cord-022353-q2k2krnm	1513	44	of	of	IN
cord-022353-q2k2krnm	1513	45	bile	bile	NN
cord-022353-q2k2krnm	1513	46	acid	acid	NN
cord-022353-q2k2krnm	1513	47	detoxification	detoxification	NN
cord-022353-q2k2krnm	1513	48	oby	oby	NNP
cord-022353-q2k2krnm	1513	49	CYP3A4	CYP3A4	NNP
cord-022353-q2k2krnm	1513	50	:	:	:
cord-022353-q2k2krnm	1513	51	studies	study	NNS
cord-022353-q2k2krnm	1513	52	in	in	IN
cord-022353-q2k2krnm	1513	53	humanized	humanize	VBN
cord-022353-q2k2krnm	1513	54	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1513	55	mice	mouse	NNS
cord-022353-q2k2krnm	1513	56	Adenovirus	Adenovirus	NNP
cord-022353-q2k2krnm	1513	57	-	-	HYPH
cord-022353-q2k2krnm	1513	58	mediated	mediate	VBN
cord-022353-q2k2krnm	1513	59	rescue	rescue	NN
cord-022353-q2k2krnm	1513	60	of	of	IN
cord-022353-q2k2krnm	1513	61	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	1513	62	lipase	lipase	NN
cord-022353-q2k2krnm	1513	63	-	-	HYPH
cord-022353-q2k2krnm	1513	64	deficient	deficient	JJ
cord-022353-q2k2krnm	1513	65	mice	mouse	NNS
cord-022353-q2k2krnm	1513	66	Breeding	breeding	NN
cord-022353-q2k2krnm	1513	67	of	of	IN
cord-022353-q2k2krnm	1513	68	the	the	DT
cord-022353-q2k2krnm	1513	69	Gad	Gad	NNP
cord-022353-q2k2krnm	1513	70	-	-	HYPH
cord-022353-q2k2krnm	1513	71	mdx	mdx	NNP
cord-022353-q2k2krnm	1513	72	mouse	mouse	NN
cord-022353-q2k2krnm	1513	73	:	:	:
cord-022353-q2k2krnm	1513	74	influence	influence	NN
cord-022353-q2k2krnm	1513	75	of	of	IN
cord-022353-q2k2krnm	1513	76	genetically	genetically	RB
cord-022353-q2k2krnm	1513	77	induced	induce	VBN
cord-022353-q2k2krnm	1513	78	denervation	denervation	NN
cord-022353-q2k2krnm	1513	79	on	on	IN
cord-022353-q2k2krnm	1513	80	dystrophic	dystrophic	JJ
cord-022353-q2k2krnm	1513	81	muscle	muscle	NN
cord-022353-q2k2krnm	1513	82	fibers	fiber	NNS
cord-022353-q2k2krnm	1513	83	Failure	failure	NN
cord-022353-q2k2krnm	1513	84	of	of	IN
cord-022353-q2k2krnm	1513	85	parturition	parturition	NN
cord-022353-q2k2krnm	1513	86	in	in	IN
cord-022353-q2k2krnm	1513	87	mice	mouse	NNS
cord-022353-q2k2krnm	1513	88	lacking	lack	VBG
cord-022353-q2k2krnm	1513	89	the	the	DT
cord-022353-q2k2krnm	1513	90	prostaglandin	prostaglandin	NN
cord-022353-q2k2krnm	1513	91	F	F	NNP
cord-022353-q2k2krnm	1513	92	receptor	receptor	NN
cord-022353-q2k2krnm	1513	93	Inactivation	Inactivation	NNP
cord-022353-q2k2krnm	1513	94	of	of	IN
cord-022353-q2k2krnm	1513	95	stress	stress	NN
cord-022353-q2k2krnm	1513	96	protein	protein	NN
cord-022353-q2k2krnm	1513	97	p8	p8	NN
cord-022353-q2k2krnm	1513	98	increases	increase	VBZ
cord-022353-q2k2krnm	1513	99	murine	murine	JJ
cord-022353-q2k2krnm	1513	100	carbon	carbon	NN
cord-022353-q2k2krnm	1513	101	tetrachloride	tetrachloride	NN
cord-022353-q2k2krnm	1513	102	hepatotoxicity	hepatotoxicity	NN
cord-022353-q2k2krnm	1513	103	via	via	IN
cord-022353-q2k2krnm	1513	104	preserved	preserve	VBN
cord-022353-q2k2krnm	1513	105	CYP2E1	CYP2E1	NNP
cord-022353-q2k2krnm	1513	106	activity	activity	NN
cord-022353-q2k2krnm	1513	107	Murine	murine	JJ
cord-022353-q2k2krnm	1513	108	models	model	NNS
cord-022353-q2k2krnm	1513	109	to	to	TO
cord-022353-q2k2krnm	1513	110	investigate	investigate	VB
cord-022353-q2k2krnm	1513	111	pharmacological	pharmacological	JJ
cord-022353-q2k2krnm	1513	112	compounds	compound	NNS
cord-022353-q2k2krnm	1513	113	acting	act	VBG
cord-022353-q2k2krnm	1513	114	as	as	IN
cord-022353-q2k2krnm	1513	115	ligands	ligand	NNS
cord-022353-q2k2krnm	1513	116	of	of	IN
cord-022353-q2k2krnm	1513	117	PPARs	ppar	NNS
cord-022353-q2k2krnm	1513	118	in	in	IN
cord-022353-q2k2krnm	1513	119	dyslipidemia	dyslipidemia	NN
cord-022353-q2k2krnm	1513	120	and	and	CC
cord-022353-q2k2krnm	1513	121	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1514	1	The	the	DT
cord-022353-q2k2krnm	1514	2	other	other	JJ
cord-022353-q2k2krnm	1514	3	side	side	NN
cord-022353-q2k2krnm	1514	4	of	of	IN
cord-022353-q2k2krnm	1514	5	the	the	DT
cord-022353-q2k2krnm	1514	6	orexins	orexin	NNS
cord-022353-q2k2krnm	1514	7	:	:	:
cord-022353-q2k2krnm	1514	8	endocrine	endocrine	JJ
cord-022353-q2k2krnm	1514	9	and	and	CC
cord-022353-q2k2krnm	1514	10	metabolic	metabolic	JJ
cord-022353-q2k2krnm	1514	11	actions	action	NNS
cord-022353-q2k2krnm	1514	12	Assessment	Assessment	NNP
cord-022353-q2k2krnm	1514	13	of	of	IN
cord-022353-q2k2krnm	1514	14	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1514	15	function	function	NN
cord-022353-q2k2krnm	1515	1	Mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	1515	2	affinity	affinity	NN
cord-022353-q2k2krnm	1515	3	for	for	IN
cord-022353-q2k2krnm	1515	4	ADP	ADP	NNP
cord-022353-q2k2krnm	1515	5	is	be	VBZ
cord-022353-q2k2krnm	1515	6	twofold	twofold	RB
cord-022353-q2k2krnm	1515	7	lower	low	JJR
cord-022353-q2k2krnm	1515	8	in	in	IN
cord-022353-q2k2krnm	1515	9	creatine	creatine	NN
cord-022353-q2k2krnm	1515	10	kinase	kinase	NN
cord-022353-q2k2krnm	1515	11	KO	KO	NNP
cord-022353-q2k2krnm	1515	12	muscles	muscle	NNS
cord-022353-q2k2krnm	1515	13	.	.	.
cord-022353-q2k2krnm	1516	1	Possible	possible	JJ
cord-022353-q2k2krnm	1516	2	role	role	NN
cord-022353-q2k2krnm	1516	3	in	in	IN
cord-022353-q2k2krnm	1516	4	rescuing	rescue	VBG
cord-022353-q2k2krnm	1516	5	cellular	cellular	JJ
cord-022353-q2k2krnm	1516	6	energy	energy	NN
cord-022353-q2k2krnm	1516	7	homeostasis	homeostasis	NN
cord-022353-q2k2krnm	1516	8	Evaluation	Evaluation	NNP
cord-022353-q2k2krnm	1516	9	of	of	IN
cord-022353-q2k2krnm	1516	10	proparacaine	proparacaine	NN
cord-022353-q2k2krnm	1516	11	hydrochloride	hydrochloride	NN
cord-022353-q2k2krnm	1516	12	as	as	IN
cord-022353-q2k2krnm	1516	13	a	a	DT
cord-022353-q2k2krnm	1516	14	topical	topical	JJ
cord-022353-q2k2krnm	1516	15	anesthetic	anesthetic	NN
cord-022353-q2k2krnm	1516	16	for	for	IN
cord-022353-q2k2krnm	1516	17	the	the	DT
cord-022353-q2k2krnm	1516	18	collection	collection	NN
cord-022353-q2k2krnm	1516	19	of	of	IN
cord-022353-q2k2krnm	1516	20	blood	blood	NN
cord-022353-q2k2krnm	1516	21	from	from	IN
cord-022353-q2k2krnm	1516	22	the	the	DT
cord-022353-q2k2krnm	1516	23	orbital	orbital	JJ
cord-022353-q2k2krnm	1516	24	sinus	sinus	NN
cord-022353-q2k2krnm	1516	25	of	of	IN
cord-022353-q2k2krnm	1516	26	mice	mouse	NNS
cord-022353-q2k2krnm	1516	27	Mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	1516	28	affinity	affinity	NN
cord-022353-q2k2krnm	1516	29	for	for	IN
cord-022353-q2k2krnm	1516	30	ADP	ADP	NNP
cord-022353-q2k2krnm	1516	31	is	be	VBZ
cord-022353-q2k2krnm	1516	32	twofold	twofold	RB
cord-022353-q2k2krnm	1516	33	lower	low	JJR
cord-022353-q2k2krnm	1516	34	in	in	IN
cord-022353-q2k2krnm	1516	35	creatine	creatine	NN
cord-022353-q2k2krnm	1516	36	kinase	kinase	NN
cord-022353-q2k2krnm	1516	37	knockout	knockout	NN
cord-022353-q2k2krnm	1516	38	muscles	muscle	NNS
cord-022353-q2k2krnm	1516	39	.	.	.
cord-022353-q2k2krnm	1517	1	Possible	possible	JJ
cord-022353-q2k2krnm	1517	2	role	role	NN
cord-022353-q2k2krnm	1517	3	in	in	IN
cord-022353-q2k2krnm	1517	4	rescuing	rescue	VBG
cord-022353-q2k2krnm	1517	5	cellular	cellular	JJ
cord-022353-q2k2krnm	1517	6	energy	energy	NN
cord-022353-q2k2krnm	1517	7	homeostasis	homeostasis	NN
cord-022353-q2k2krnm	1518	1	The	the	DT
cord-022353-q2k2krnm	1518	2	role	role	NN
cord-022353-q2k2krnm	1518	3	of	of	IN
cord-022353-q2k2krnm	1518	4	CD40-CD154	CD40-CD154	VBN
cord-022353-q2k2krnm	1518	5	interactions	interaction	NNS
cord-022353-q2k2krnm	1518	6	in	in	IN
cord-022353-q2k2krnm	1518	7	autoimmunity	autoimmunity	NN
cord-022353-q2k2krnm	1518	8	and	and	CC
cord-022353-q2k2krnm	1518	9	the	the	DT
cord-022353-q2k2krnm	1518	10	benefit	benefit	NN
cord-022353-q2k2krnm	1518	11	of	of	IN
cord-022353-q2k2krnm	1518	12	disrupting	disrupt	VBG
cord-022353-q2k2krnm	1518	13	this	this	DT
cord-022353-q2k2krnm	1518	14	pathway	pathway	NN
cord-022353-q2k2krnm	1518	15	Scavenger	Scavenger	NNP
cord-022353-q2k2krnm	1518	16	receptor	receptor	NN
cord-022353-q2k2krnm	1518	17	class	class	NN
cord-022353-q2k2krnm	1518	18	B	b	NN
cord-022353-q2k2krnm	1518	19	type	type	NN
cord-022353-q2k2krnm	1518	20	1	1	CD
cord-022353-q2k2krnm	1518	21	in	in	IN
cord-022353-q2k2krnm	1518	22	high	high	JJ
cord-022353-q2k2krnm	1518	23	-	-	HYPH
cord-022353-q2k2krnm	1518	24	density	density	NN
cord-022353-q2k2krnm	1518	25	lipoprotein	lipoprotein	NN
cord-022353-q2k2krnm	1518	26	metabolism	metabolism	NN
cord-022353-q2k2krnm	1518	27	,	,	,
cord-022353-q2k2krnm	1518	28	atherosclerosis	atherosclerosis	NN
cord-022353-q2k2krnm	1518	29	,	,	,
cord-022353-q2k2krnm	1518	30	and	and	CC
cord-022353-q2k2krnm	1518	31	heart	heart	NN
cord-022353-q2k2krnm	1518	32	disease	disease	NN
cord-022353-q2k2krnm	1518	33	:	:	:
cord-022353-q2k2krnm	1518	34	lessons	lesson	NNS
cord-022353-q2k2krnm	1518	35	from	from	IN
cord-022353-q2k2krnm	1518	36	gene	gene	NN
cord-022353-q2k2krnm	1518	37	targeted	target	VBN
cord-022353-q2k2krnm	1518	38	mice	mouse	NNS
cord-022353-q2k2krnm	1519	1	CXC	CXC	NNP
cord-022353-q2k2krnm	1519	2	chemokine	chemokine	NN
cord-022353-q2k2krnm	1519	3	receptor	receptor	NN
cord-022353-q2k2krnm	1519	4	CXCR2	CXCR2	NNS
cord-022353-q2k2krnm	1519	5	is	be	VBZ
cord-022353-q2k2krnm	1519	6	essential	essential	JJ
cord-022353-q2k2krnm	1519	7	for	for	IN
cord-022353-q2k2krnm	1519	8	protective	protective	JJ
cord-022353-q2k2krnm	1519	9	innate	innate	JJ
cord-022353-q2k2krnm	1519	10	host	host	NN
cord-022353-q2k2krnm	1519	11	response	response	NN
cord-022353-q2k2krnm	1519	12	in	in	IN
cord-022353-q2k2krnm	1519	13	murine	murine	JJ
cord-022353-q2k2krnm	1519	14	pseudomonas	pseudomonas	NNP
cord-022353-q2k2krnm	1519	15	aeruginosa	aeruginosa	NNP
cord-022353-q2k2krnm	1519	16	pneumonia	pneumonia	NNP
cord-022353-q2k2krnm	1520	1	In	in	IN
cord-022353-q2k2krnm	1520	2	vivo	vivo	NN
cord-022353-q2k2krnm	1520	3	uptake	uptake	NN
cord-022353-q2k2krnm	1520	4	of	of	IN
cord-022353-q2k2krnm	1520	5	radiolabeled	radiolabele	VBN
cord-022353-q2k2krnm	1520	6	MDA2	MDA2	NNP
cord-022353-q2k2krnm	1520	7	,	,	,
cord-022353-q2k2krnm	1520	8	an	an	DT
cord-022353-q2k2krnm	1520	9	oxidation	oxidation	NN
cord-022353-q2k2krnm	1520	10	-	-	HYPH
cord-022353-q2k2krnm	1520	11	specific	specific	JJ
cord-022353-q2k2krnm	1520	12	monoclonal	monoclonal	JJ
cord-022353-q2k2krnm	1520	13	antibody	antibody	NN
cord-022353-q2k2krnm	1520	14	,	,	,
cord-022353-q2k2krnm	1520	15	provides	provide	VBZ
cord-022353-q2k2krnm	1520	16	an	an	DT
cord-022353-q2k2krnm	1520	17	accurate	accurate	JJ
cord-022353-q2k2krnm	1520	18	measure	measure	NN
cord-022353-q2k2krnm	1520	19	of	of	IN
cord-022353-q2k2krnm	1520	20	atherosclerotic	atherosclerotic	JJ
cord-022353-q2k2krnm	1520	21	lesions	lesion	NNS
cord-022353-q2k2krnm	1520	22	rich	rich	JJ
cord-022353-q2k2krnm	1520	23	in	in	IN
cord-022353-q2k2krnm	1520	24	oxidized	oxidized	JJ
cord-022353-q2k2krnm	1520	25	LDL	ldl	NN
cord-022353-q2k2krnm	1520	26	and	and	CC
cord-022353-q2k2krnm	1520	27	is	be	VBZ
cord-022353-q2k2krnm	1520	28	highly	highly	RB
cord-022353-q2k2krnm	1520	29	sensitive	sensitive	JJ
cord-022353-q2k2krnm	1520	30	to	to	IN
cord-022353-q2k2krnm	1520	31	their	-PRON-	PRP$
cord-022353-q2k2krnm	1520	32	regression	regression	NN
cord-022353-q2k2krnm	1521	1	The	the	DT
cord-022353-q2k2krnm	1521	2	regulation	regulation	NN
cord-022353-q2k2krnm	1521	3	of	of	IN
cord-022353-q2k2krnm	1521	4	the	the	DT
cord-022353-q2k2krnm	1521	5	complement	complement	NN
cord-022353-q2k2krnm	1521	6	system	system	NN
cord-022353-q2k2krnm	1521	7	:	:	:
cord-022353-q2k2krnm	1521	8	insights	insight	NNS
cord-022353-q2k2krnm	1521	9	from	from	IN
cord-022353-q2k2krnm	1521	10	genetically	genetically	RB
cord-022353-q2k2krnm	1521	11	-	-	HYPH
cord-022353-q2k2krnm	1521	12	engineered	engineer	VBN
cord-022353-q2k2krnm	1521	13	mice	mouse	NNS
cord-022353-q2k2krnm	1522	1	Interleukin-6	Interleukin-6	NNP
cord-022353-q2k2krnm	1522	2	:	:	:
cord-022353-q2k2krnm	1523	1	an	an	DT
cord-022353-q2k2krnm	1523	2	overview	overview	NN
cord-022353-q2k2krnm	1523	3	Development	development	NN
cord-022353-q2k2krnm	1523	4	of	of	IN
cord-022353-q2k2krnm	1523	5	a	a	DT
cord-022353-q2k2krnm	1523	6	novel	novel	JJ
cord-022353-q2k2krnm	1523	7	proteomic	proteomic	JJ
cord-022353-q2k2krnm	1523	8	approach	approach	NN
cord-022353-q2k2krnm	1523	9	for	for	IN
cord-022353-q2k2krnm	1523	10	the	the	DT
cord-022353-q2k2krnm	1523	11	detection	detection	NN
cord-022353-q2k2krnm	1523	12	of	of	IN
cord-022353-q2k2krnm	1523	13	transitional	transitional	JJ
cord-022353-q2k2krnm	1523	14	cell	cell	NN
cord-022353-q2k2krnm	1523	15	carcinoma	carcinoma	NN
cord-022353-q2k2krnm	1523	16	of	of	IN
cord-022353-q2k2krnm	1523	17	the	the	DT
cord-022353-q2k2krnm	1523	18	bladder	bladder	NN
cord-022353-q2k2krnm	1523	19	in	in	IN
cord-022353-q2k2krnm	1523	20	urine	urine	NN
cord-022353-q2k2krnm	1523	21	Mechanisms	mechanism	NNS
cord-022353-q2k2krnm	1523	22	of	of	IN
cord-022353-q2k2krnm	1523	23	suppression	suppression	NN
cord-022353-q2k2krnm	1523	24	by	by	IN
cord-022353-q2k2krnm	1523	25	suppressor	suppressor	NNP
cord-022353-q2k2krnm	1523	26	T	T	NNP
cord-022353-q2k2krnm	1523	27	-	-	HYPH
cord-022353-q2k2krnm	1523	28	cells	cell	NNS
cord-022353-q2k2krnm	1523	29	Lipids	lipid	NNS
cord-022353-q2k2krnm	1523	30	and	and	CC
cord-022353-q2k2krnm	1523	31	lipoproteins	lipoprotein	NNS
cord-022353-q2k2krnm	1523	32	CAR	car	NN
cord-022353-q2k2krnm	1523	33	and	and	CC
cord-022353-q2k2krnm	1523	34	PXR	PXR	NNP
cord-022353-q2k2krnm	1523	35	agonists	agonist	NNS
cord-022353-q2k2krnm	1523	36	stimulate	stimulate	VBP
cord-022353-q2k2krnm	1523	37	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1523	38	bile	bile	NN
cord-022353-q2k2krnm	1523	39	acid	acid	NN
cord-022353-q2k2krnm	1523	40	and	and	CC
cord-022353-q2k2krnm	1523	41	bilirubin	bilirubin	NN
cord-022353-q2k2krnm	1523	42	detoxification	detoxification	NN
cord-022353-q2k2krnm	1523	43	and	and	CC
cord-022353-q2k2krnm	1523	44	elimination	elimination	NN
cord-022353-q2k2krnm	1523	45	in	in	IN
cord-022353-q2k2krnm	1523	46	mice	mouse	NNS
cord-022353-q2k2krnm	1523	47	Pneumocystis	Pneumocystis	NNP
cord-022353-q2k2krnm	1523	48	carinii	carinii	NN
cord-022353-q2k2krnm	1523	49	activates	activate	VBZ
cord-022353-q2k2krnm	1523	50	the	the	DT
cord-022353-q2k2krnm	1523	51	NF	nf	NN
cord-022353-q2k2krnm	1523	52	-	-	HYPH
cord-022353-q2k2krnm	1523	53	kappa[~	kappa[~	NNP
cord-022353-q2k2krnm	1523	54	signaling	signal	VBG
cord-022353-q2k2krnm	1523	55	pathway	pathway	NN
cord-022353-q2k2krnm	1523	56	in	in	IN
cord-022353-q2k2krnm	1523	57	alveolar	alveolar	JJ
cord-022353-q2k2krnm	1523	58	epithelial	epithelial	JJ
cord-022353-q2k2krnm	1523	59	cells	cell	NNS
cord-022353-q2k2krnm	1524	1	A	a	DT
cord-022353-q2k2krnm	1524	2	simple	simple	JJ
cord-022353-q2k2krnm	1524	3	capillary	capillary	JJ
cord-022353-q2k2krnm	1524	4	tube	tube	NN
cord-022353-q2k2krnm	1524	5	method	method	NN
cord-022353-q2k2krnm	1524	6	for	for	IN
cord-022353-q2k2krnm	1524	7	the	the	DT
cord-022353-q2k2krnm	1524	8	determination	determination	NN
cord-022353-q2k2krnm	1524	9	of	of	IN
cord-022353-q2k2krnm	1524	10	the	the	DT
cord-022353-q2k2krnm	1524	11	specific	specific	JJ
cord-022353-q2k2krnm	1524	12	gravity	gravity	NN
cord-022353-q2k2krnm	1524	13	of	of	IN
cord-022353-q2k2krnm	1524	14	25	25	CD
cord-022353-q2k2krnm	1524	15	and	and	CC
cord-022353-q2k2krnm	1524	16	50	50	CD
cord-022353-q2k2krnm	1524	17	micro	micro	JJ
cord-022353-q2k2krnm	1524	18	1	1	CD
cord-022353-q2k2krnm	1524	19	quantities	quantity	NNS
cord-022353-q2k2krnm	1524	20	of	of	IN
cord-022353-q2k2krnm	1524	21	urine	urine	NN
cord-022353-q2k2krnm	1525	1	Interleukin-18	Interleukin-18	NNP
cord-022353-q2k2krnm	1525	2	facilitates	facilitate	VBZ
cord-022353-q2k2krnm	1525	3	the	the	DT
cord-022353-q2k2krnm	1525	4	early	early	JJ
cord-022353-q2k2krnm	1525	5	antimicrobial	antimicrobial	JJ
cord-022353-q2k2krnm	1525	6	host	host	NN
cord-022353-q2k2krnm	1525	7	response	response	NN
cord-022353-q2k2krnm	1525	8	to	to	IN
cord-022353-q2k2krnm	1525	9	Escherichia	Escherichia	NNP
cord-022353-q2k2krnm	1525	10	coli	coli	NNS
cord-022353-q2k2krnm	1525	11	peritonitis	peritonitis	NN
cord-022353-q2k2krnm	1525	12	Transgenic	transgenic	JJ
cord-022353-q2k2krnm	1525	13	studies	study	NNS
cord-022353-q2k2krnm	1525	14	on	on	IN
cord-022353-q2k2krnm	1525	15	the	the	DT
cord-022353-q2k2krnm	1525	16	regulation	regulation	NN
cord-022353-q2k2krnm	1525	17	of	of	IN
cord-022353-q2k2krnm	1525	18	the	the	DT
cord-022353-q2k2krnm	1525	19	anterior	anterior	JJ
cord-022353-q2k2krnm	1525	20	pituitary	pituitary	JJ
cord-022353-q2k2krnm	1525	21	gland	gland	NN
cord-022353-q2k2krnm	1525	22	function	function	NN
cord-022353-q2k2krnm	1525	23	by	by	IN
cord-022353-q2k2krnm	1525	24	the	the	DT
cord-022353-q2k2krnm	1525	25	hypothalamus	hypothalamus	NN
cord-022353-q2k2krnm	1526	1	CXCR3	CXCR3	NNP
cord-022353-q2k2krnm	1526	2	and	and	CC
cord-022353-q2k2krnm	1526	3	its	-PRON-	PRP$
cord-022353-q2k2krnm	1526	4	ligand	ligand	NN
cord-022353-q2k2krnm	1526	5	participate	participate	VBP
cord-022353-q2k2krnm	1526	6	in	in	IN
cord-022353-q2k2krnm	1526	7	the	the	DT
cord-022353-q2k2krnm	1526	8	host	host	NN
cord-022353-q2k2krnm	1526	9	response	response	NN
cord-022353-q2k2krnm	1526	10	to	to	IN
cord-022353-q2k2krnm	1526	11	Bordetella	Bordetella	NNP
cord-022353-q2k2krnm	1526	12	bronchiseptica	bronchiseptica	NNP
cord-022353-q2k2krnm	1526	13	infection	infection	NN
cord-022353-q2k2krnm	1526	14	of	of	IN
cord-022353-q2k2krnm	1526	15	the	the	DT
cord-022353-q2k2krnm	1526	16	mouse	mouse	NN
cord-022353-q2k2krnm	1526	17	respiratory	respiratory	JJ
cord-022353-q2k2krnm	1526	18	tract	tract	NN
cord-022353-q2k2krnm	1526	19	but	but	CC
cord-022353-q2k2krnm	1526	20	are	be	VBP
cord-022353-q2k2krnm	1526	21	not	not	RB
cord-022353-q2k2krnm	1526	22	required	require	VBN
cord-022353-q2k2krnm	1526	23	for	for	IN
cord-022353-q2k2krnm	1526	24	clearance	clearance	NN
cord-022353-q2k2krnm	1526	25	of	of	IN
cord-022353-q2k2krnm	1526	26	bacteria	bacteria	NNS
cord-022353-q2k2krnm	1526	27	from	from	IN
cord-022353-q2k2krnm	1526	28	the	the	DT
cord-022353-q2k2krnm	1526	29	lung	lung	NN
cord-022353-q2k2krnm	1526	30	A	a	DT
cord-022353-q2k2krnm	1526	31	direct	direct	JJ
cord-022353-q2k2krnm	1526	32	intersection	intersection	NN
cord-022353-q2k2krnm	1526	33	between	between	IN
cord-022353-q2k2krnm	1526	34	p53	p53	NN
cord-022353-q2k2krnm	1526	35	and	and	CC
cord-022353-q2k2krnm	1526	36	transforming	transform	VBG
cord-022353-q2k2krnm	1526	37	growth	growth	NN
cord-022353-q2k2krnm	1526	38	factor	factor	NN
cord-022353-q2k2krnm	1526	39	beta	beta	NN
cord-022353-q2k2krnm	1526	40	pathways	pathway	NNS
cord-022353-q2k2krnm	1526	41	targets	target	NNS
cord-022353-q2k2krnm	1526	42	chromatin	chromatin	NN
cord-022353-q2k2krnm	1526	43	modification	modification	NN
cord-022353-q2k2krnm	1526	44	and	and	CC
cord-022353-q2k2krnm	1526	45	transcription	transcription	NN
cord-022353-q2k2krnm	1526	46	repression	repression	NN
cord-022353-q2k2krnm	1526	47	of	of	IN
cord-022353-q2k2krnm	1526	48	the	the	DT
cord-022353-q2k2krnm	1526	49	alpha	alpha	NN
cord-022353-q2k2krnm	1526	50	-	-	HYPH
cord-022353-q2k2krnm	1526	51	fetoprotein	fetoprotein	NNP
cord-022353-q2k2krnm	1526	52	gene	gene	NN
cord-022353-q2k2krnm	1526	53	Assessment	Assessment	NNP
cord-022353-q2k2krnm	1526	54	of	of	IN
cord-022353-q2k2krnm	1526	55	hepatic	hepatic	JJ
cord-022353-q2k2krnm	1526	56	function	function	NN
cord-022353-q2k2krnm	1526	57	and	and	CC
cord-022353-q2k2krnm	1526	58	damage	damage	NN
cord-022353-q2k2krnm	1526	59	in	in	IN
cord-022353-q2k2krnm	1526	60	animal	animal	NN
cord-022353-q2k2krnm	1526	61	species	specie	NNS
cord-022353-q2k2krnm	1526	62	Laboratory	Laboratory	NNP
cord-022353-q2k2krnm	1526	63	animal	animal	NN
cord-022353-q2k2krnm	1526	64	endocrinology	endocrinology	NNP
cord-022353-q2k2krnm	1526	65	Investigation	Investigation	NNP
cord-022353-q2k2krnm	1526	66	of	of	IN
cord-022353-q2k2krnm	1526	67	antitumor	antitumor	JJ
cord-022353-q2k2krnm	1526	68	effects	effect	NNS
cord-022353-q2k2krnm	1526	69	of	of	IN
cord-022353-q2k2krnm	1526	70	synthetic	synthetic	JJ
cord-022353-q2k2krnm	1526	71	epothilone	epothilone	JJ
cord-022353-q2k2krnm	1526	72	analogs	analog	NNS
cord-022353-q2k2krnm	1526	73	in	in	IN
cord-022353-q2k2krnm	1526	74	human	human	JJ
cord-022353-q2k2krnm	1526	75	myeloma	myeloma	NN
cord-022353-q2k2krnm	1526	76	models	model	NNS
cord-022353-q2k2krnm	1526	77	in	in	IN
cord-022353-q2k2krnm	1526	78	vitro	vitro	FW
cord-022353-q2k2krnm	1526	79	and	and	CC
cord-022353-q2k2krnm	1526	80	in	in	IN
cord-022353-q2k2krnm	1526	81	vivo	vivo	NN
cord-022353-q2k2krnm	1527	1	The	the	DT
cord-022353-q2k2krnm	1527	2	protein	protein	NN
cord-022353-q2k2krnm	1527	3	profile	profile	NN
cord-022353-q2k2krnm	1527	4	of	of	IN
cord-022353-q2k2krnm	1527	5	acetazolamidetreated	acetazolamidetreated	NNP
cord-022353-q2k2krnm	1527	6	sera	sera	NNP
cord-022353-q2k2krnm	1527	7	in	in	IN
cord-022353-q2k2krnm	1527	8	mice	mouse	NNS
cord-022353-q2k2krnm	1527	9	bearing	bear	VBG
cord-022353-q2k2krnm	1527	10	Lewis	Lewis	NNP
cord-022353-q2k2krnm	1527	11	neoplasm	neoplasm	NN
cord-022353-q2k2krnm	1527	12	CEBS	cebs	NN
cord-022353-q2k2krnm	1527	13	object	object	NN
cord-022353-q2k2krnm	1527	14	modes	mode	NNS
cord-022353-q2k2krnm	1527	15	for	for	IN
cord-022353-q2k2krnm	1527	16	systems	system	NNS
cord-022353-q2k2krnm	1527	17	biology	biology	NN
cord-022353-q2k2krnm	1527	18	data	datum	NNS
cord-022353-q2k2krnm	1527	19	,	,	,
cord-022353-q2k2krnm	1527	20	SysBio	SysBio	NNP
cord-022353-q2k2krnm	1527	21	-	-	HYPH
cord-022353-q2k2krnm	1527	22	OM	OM	NNP
cord-022353-q2k2krnm	1527	23	Partal	Partal	NNP
cord-022353-q2k2krnm	1527	24	hormone	hormone	NN
cord-022353-q2k2krnm	1527	25	resistance	resistance	NN
cord-022353-q2k2krnm	1527	26	in	in	IN
cord-022353-q2k2krnm	1527	27	mice	mouse	NNS
cord-022353-q2k2krnm	1527	28	with	with	IN
cord-022353-q2k2krnm	1527	29	disruption	disruption	NN
cord-022353-q2k2krnm	1527	30	of	of	IN
cord-022353-q2k2krnm	1527	31	the	the	DT
cord-022353-q2k2krnm	1527	32	steroid	steroid	NN
cord-022353-q2k2krnm	1527	33	receptor	receptor	NN
cord-022353-q2k2krnm	1527	34	coactivator-1	coactivator-1	NNP
cord-022353-q2k2krnm	1527	35	(	(	-LRB-
cord-022353-q2k2krnm	1527	36	SRC-1	SRC-1	NNP
cord-022353-q2k2krnm	1527	37	)	)	-RRB-
cord-022353-q2k2krnm	1527	38	gene	gene	NN
cord-022353-q2k2krnm	1527	39	Platelet	platelet	NN
cord-022353-q2k2krnm	1527	40	factor	factor	NN
cord-022353-q2k2krnm	1527	41	4	4	CD
cord-022353-q2k2krnm	1527	42	gene	gene	NN
cord-022353-q2k2krnm	1527	43	transfection	transfection	NN
cord-022353-q2k2krnm	1527	44	into	into	IN
cord-022353-q2k2krnm	1527	45	tumor	tumor	NN
cord-022353-q2k2krnm	1527	46	cells	cell	NNS
cord-022353-q2k2krnm	1527	47	inhibits	inhibit	VBZ
cord-022353-q2k2krnm	1527	48	angrogenesis	angrogenesis	NN
cord-022353-q2k2krnm	1527	49	tumor	tumor	NN
cord-022353-q2k2krnm	1527	50	growth	growth	NN
cord-022353-q2k2krnm	1527	51	and	and	CC
cord-022353-q2k2krnm	1527	52	metastasis	metastasis	NN
cord-022353-q2k2krnm	1527	53	Mice	mouse	NNS
cord-022353-q2k2krnm	1527	54	lacking	lack	VBG
cord-022353-q2k2krnm	1527	55	the	the	DT
cord-022353-q2k2krnm	1527	56	thyrotropin	thyrotropin	RB
cord-022353-q2k2krnm	1527	57	-	-	HYPH
cord-022353-q2k2krnm	1527	58	releasing	release	VBG
cord-022353-q2k2krnm	1527	59	hormone	hormone	NN
cord-022353-q2k2krnm	1527	60	gene	gene	NN
cord-022353-q2k2krnm	1527	61	:	:	:
cord-022353-q2k2krnm	1527	62	what	what	WP
cord-022353-q2k2krnm	1527	63	do	do	VBP
cord-022353-q2k2krnm	1527	64	they	-PRON-	PRP
cord-022353-q2k2krnm	1527	65	tell	tell	VB
cord-022353-q2k2krnm	1527	66	us	-PRON-	PRP
cord-022353-q2k2krnm	1527	67	?	?	.
cord-022353-q2k2krnm	1528	1	Differences	difference	NNS
cord-022353-q2k2krnm	1528	2	in	in	IN
cord-022353-q2k2krnm	1528	3	the	the	DT
cord-022353-q2k2krnm	1528	4	human	human	JJ
cord-022353-q2k2krnm	1528	5	and	and	CC
cord-022353-q2k2krnm	1528	6	mouse	mouse	NN
cord-022353-q2k2krnm	1528	7	amino	amino	NN
cord-022353-q2k2krnm	1528	8	-	-	HYPH
cord-022353-q2k2krnm	1528	9	terminal	terminal	NN
cord-022353-q2k2krnm	1528	10	leader	leader	NN
cord-022353-q2k2krnm	1528	11	peptides	peptide	NNS
cord-022353-q2k2krnm	1528	12	of	of	IN
cord-022353-q2k2krnm	1528	13	ornithine	ornithine	NN
cord-022353-q2k2krnm	1528	14	transcarbamylase	transcarbamylase	NN
cord-022353-q2k2krnm	1528	15	affect	affect	VBP
cord-022353-q2k2krnm	1528	16	mitochondrial	mitochondrial	JJ
cord-022353-q2k2krnm	1528	17	import	import	NN
cord-022353-q2k2krnm	1528	18	and	and	CC
cord-022353-q2k2krnm	1528	19	efficacy	efficacy	NN
cord-022353-q2k2krnm	1528	20	of	of	IN
cord-022353-q2k2krnm	1528	21	adenoviral	adenoviral	NNP
cord-022353-q2k2krnm	1528	22	vectors	vector	NNS
cord-022353-q2k2krnm	1529	1	Combined	combined	JJ
cord-022353-q2k2krnm	1529	2	pituitary	pituitary	JJ
cord-022353-q2k2krnm	1529	3	hormone	hormone	NN
cord-022353-q2k2krnm	1529	4	deficiency	deficiency	NN
cord-022353-q2k2krnm	1529	5	:	:	:
cord-022353-q2k2krnm	1530	1	lessons	lesson	NNS
cord-022353-q2k2krnm	1530	2	from	from	IN
cord-022353-q2k2krnm	1530	3	the	the	DT
cord-022353-q2k2krnm	1530	4	murine	murine	JJ
cord-022353-q2k2krnm	1530	5	models	model	NNS
cord-022353-q2k2krnm	1530	6	Molecular	molecular	JJ
cord-022353-q2k2krnm	1530	7	basis	basis	NN
cord-022353-q2k2krnm	1530	8	of	of	IN
cord-022353-q2k2krnm	1530	9	resistance	resistance	NN
cord-022353-q2k2krnm	1530	10	to	to	IN
cord-022353-q2k2krnm	1530	11	thyroid	thyroid	JJ
cord-022353-q2k2krnm	1530	12	hormone	hormone	NN
cord-022353-q2k2krnm	1531	1	A	a	DT
cord-022353-q2k2krnm	1531	2	mouse	mouse	NN
cord-022353-q2k2krnm	1531	3	bleeding	bleed	VBG
cord-022353-q2k2krnm	1531	4	technique	technique	NN
cord-022353-q2k2krnm	1531	5	yielding	yield	VBG
cord-022353-q2k2krnm	1531	6	consistent	consistent	JJ
cord-022353-q2k2krnm	1531	7	volume	volume	NN
cord-022353-q2k2krnm	1531	8	with	with	IN
cord-022353-q2k2krnm	1531	9	minimal	minimal	JJ
cord-022353-q2k2krnm	1531	10	hemolysis	hemolysis	NN
cord-022353-q2k2krnm	1531	11	Transgenesis	transgenesis	NN
cord-022353-q2k2krnm	1531	12	and	and	CC
cord-022353-q2k2krnm	1531	13	the	the	DT
cord-022353-q2k2krnm	1531	14	study	study	NN
cord-022353-q2k2krnm	1531	15	of	of	IN
cord-022353-q2k2krnm	1531	16	expression	expression	NN
cord-022353-q2k2krnm	1531	17	,	,	,
cord-022353-q2k2krnm	1531	18	cellular	cellular	JJ
cord-022353-q2k2krnm	1531	19	targeting	targeting	NN
cord-022353-q2k2krnm	1531	20	,	,	,
cord-022353-q2k2krnm	1531	21	and	and	CC
cord-022353-q2k2krnm	1531	22	function	function	NN
cord-022353-q2k2krnm	1531	23	of	of	IN
cord-022353-q2k2krnm	1531	24	oxytocin	oxytocin	NN
cord-022353-q2k2krnm	1531	25	,	,	,
cord-022353-q2k2krnm	1531	26	vasopressin	vasopressin	NN
cord-022353-q2k2krnm	1531	27	and	and	CC
cord-022353-q2k2krnm	1531	28	their	-PRON-	PRP$
cord-022353-q2k2krnm	1531	29	receptors	receptor	NNS
cord-022353-q2k2krnm	1531	30	KOs	KOs	NNP
cord-022353-q2k2krnm	1531	31	model	model	VBP
cord-022353-q2k2krnm	1531	32	the	the	DT
cord-022353-q2k2krnm	1531	33	100	100	CD
cord-022353-q2k2krnm	1531	34	best	well	RBS
cord-022353-q2k2krnm	1531	35	-	-	HYPH
cord-022353-q2k2krnm	1531	36	selling	sell	VBG
cord-022353-q2k2krnm	1531	37	drugs	drug	NNS
cord-022353-q2k2krnm	1531	38	:	:	:
cord-022353-q2k2krnm	1531	39	will	will	MD
cord-022353-q2k2krnm	1531	40	they	-PRON-	PRP
cord-022353-q2k2krnm	1531	41	model	model	VB
cord-022353-q2k2krnm	1531	42	the	the	DT
cord-022353-q2k2krnm	1531	43	next	next	JJ
cord-022353-q2k2krnm	1531	44	100	100	CD
cord-022353-q2k2krnm	1531	45	?	?	.
cord-022353-q2k2krnm	1532	1	Predicting	predict	VBG
cord-022353-q2k2krnm	1532	2	drug	drug	NN
cord-022353-q2k2krnm	1532	3	efficacy	efficacy	NN
cord-022353-q2k2krnm	1532	4	:	:	:
cord-022353-q2k2krnm	1532	5	KOs	KOs	NNP
cord-022353-q2k2krnm	1532	6	model	model	NN
cord-022353-q2k2krnm	1532	7	pipeline	pipeline	NN
cord-022353-q2k2krnm	1532	8	drugs	drug	NNS
cord-022353-q2k2krnm	1532	9	of	of	IN
cord-022353-q2k2krnm	1532	10	the	the	DT
cord-022353-q2k2krnm	1532	11	pharmaceutical	pharmaceutical	JJ
cord-022353-q2k2krnm	1532	12	industry	industry	NN
cord-022353-q2k2krnm	1532	13	Three	three	CD
cord-022353-q2k2krnm	1532	14	biomarkers	biomarker	NNS
cord-022353-q2k2krnm	1532	15	identified	identify	VBN
cord-022353-q2k2krnm	1532	16	from	from	IN
cord-022353-q2k2krnm	1532	17	serum	serum	NN
cord-022353-q2k2krnm	1532	18	proteomic	proteomic	JJ
cord-022353-q2k2krnm	1532	19	analysis	analysis	NN
cord-022353-q2k2krnm	1532	20	for	for	IN
cord-022353-q2k2krnm	1532	21	the	the	DT
cord-022353-q2k2krnm	1532	22	detection	detection	NN
cord-022353-q2k2krnm	1532	23	of	of	IN
cord-022353-q2k2krnm	1532	24	early	early	JJ
cord-022353-q2k2krnm	1532	25	stage	stage	NN
cord-022353-q2k2krnm	1532	26	ovarian	ovarian	JJ
cord-022353-q2k2krnm	1532	27	cancer	cancer	NN
cord-022353-q2k2krnm	1533	1	CXC	CXC	NNP
cord-022353-q2k2krnm	1533	2	chemokine	chemokine	NN
cord-022353-q2k2krnm	1533	3	ligand	ligand	NN
cord-022353-q2k2krnm	1533	4	129	129	CD
cord-022353-q2k2krnm	1533	5	stromal	stromal	JJ
cord-022353-q2k2krnm	1533	6	cell	cell	NN
cord-022353-q2k2krnm	1533	7	-	-	HYPH
cord-022353-q2k2krnm	1533	8	derived	derive	VBN
cord-022353-q2k2krnm	1533	9	factor	factor	NN
cord-022353-q2k2krnm	1533	10	1	1	CD
cord-022353-q2k2krnm	1533	11	alpha	alpha	NN
cord-022353-q2k2krnm	1533	12	and	and	CC
cord-022353-q2k2krnm	1533	13	CXCR4-dependent	CXCR4-dependent	NNP
cord-022353-q2k2krnm	1533	14	migration	migration	NN
cord-022353-q2k2krnm	1533	15	of	of	IN
cord-022353-q2k2krnm	1533	16	CTLs	ctl	NNS
cord-022353-q2k2krnm	1533	17	toward	toward	IN
cord-022353-q2k2krnm	1533	18	melanoma	melanoma	NN
cord-022353-q2k2krnm	1533	19	cells	cell	NNS
cord-022353-q2k2krnm	1533	20	in	in	IN
cord-022353-q2k2krnm	1533	21	organotypic	organotypic	JJ
cord-022353-q2k2krnm	1533	22	culture	culture	NN
cord-022353-q2k2krnm	1533	23	IL	IL	NNP
cord-022353-q2k2krnm	1533	24	-	-	HYPH
cord-022353-q2k2krnm	1533	25	II	II	NNP
cord-022353-q2k2krnm	1533	26	:	:	:
cord-022353-q2k2krnm	1534	1	Insights	insight	NNS
cord-022353-q2k2krnm	1534	2	in	in	IN
cord-022353-q2k2krnm	1534	3	asthma	asthma	NN
cord-022353-q2k2krnm	1534	4	from	from	IN
cord-022353-q2k2krnm	1534	5	overexpression	overexpression	NN
cord-022353-q2k2krnm	1534	6	transgenic	transgenic	JJ
cord-022353-q2k2krnm	1534	7	modeling	modeling	NN
cord-022353-q2k2krnm	1534	8	Genotype	genotype	NN
cord-022353-q2k2krnm	1534	9	,	,	,
cord-022353-q2k2krnm	1534	10	obesity	obesity	NN
cord-022353-q2k2krnm	1534	11	,	,	,
cord-022353-q2k2krnm	1534	12	and	and	CC
cord-022353-q2k2krnm	1534	13	cardiovascular	cardiovascular	JJ
cord-022353-q2k2krnm	1534	14	disease	disease	NN
cord-022353-q2k2krnm	1534	15	:	:	:
cord-022353-q2k2krnm	1534	16	has	have	VBZ
cord-022353-q2k2krnm	1534	17	technical	technical	JJ
cord-022353-q2k2krnm	1534	18	and	and	CC
cord-022353-q2k2krnm	1534	19	social	social	JJ
cord-022353-q2k2krnm	1534	20	advance	advance	NN
cord-022353-q2k2krnm	1534	21	outstripped	outstrip	VBD
cord-022353-q2k2krnm	1534	22	evolution	evolution	NN
cord-022353-q2k2krnm	1534	23	?	?	.
cord-022353-q2k2krnm	1535	1	Specific	specific	JJ
cord-022353-q2k2krnm	1535	2	fetal	fetal	JJ
cord-022353-q2k2krnm	1535	3	serum	serum	NN
cord-022353-q2k2krnm	1535	4	proteins	protein	NNS
cord-022353-q2k2krnm	1535	5	of	of	IN
cord-022353-q2k2krnm	1535	6	13	13	CD
cord-022353-q2k2krnm	1535	7	mammalian	mammalian	JJ
cord-022353-q2k2krnm	1535	8	species	specie	NNS
cord-022353-q2k2krnm	1535	9	 	 	_SP
cord-022353-q2k2krnm	1536	1	T3	T3	NNP
cord-022353-q2k2krnm	1536	2	 	 	_SP
cord-022353-q2k2krnm	1537	1	T4	T4	NNP
cord-022353-q2k2krnm	1537	2	 	 	_SP
cord-022353-q2k2krnm	1538	1	TACE	TACE	NNP
cord-022353-q2k2krnm	1538	2	 	 	_SP
cord-022353-q2k2krnm	1539	1	TAJ	TAJ	NNP
cord-022353-q2k2krnm	1539	2	 	 	_SP
cord-022353-q2k2krnm	1540	1	Tc	Tc	NNP
cord-022353-q2k2krnm	1540	2	 	 	_SP
cord-022353-q2k2krnm	1540	3	TG	TG	NNP
cord-022353-q2k2krnm	1540	4	 	 	_SP
cord-022353-q2k2krnm	1540	5	TGF	TGF	NNP
cord-022353-q2k2krnm	1540	6	-	-	HYPH
cord-022353-q2k2krnm	1540	7	I3	I3	NNP
cord-022353-q2k2krnm	1540	8	 	 	_SP
cord-022353-q2k2krnm	1540	9	TGF-~ISF	TGF-~ISF	NNP
cord-022353-q2k2krnm	1540	10	 	 	_SP
cord-022353-q2k2krnm	1541	1	TH	TH	NNP
cord-022353-q2k2krnm	1541	2	 	 	_SP
cord-022353-q2k2krnm	1542	1	TLR	TLR	NNP
cord-022353-q2k2krnm	1542	2	 	 	_SP
cord-022353-q2k2krnm	1542	3	TNAP	TNAP	NNP
cord-022353-q2k2krnm	1542	4	 	 	_SP
cord-022353-q2k2krnm	1543	1	TNF	TNF	NNP
cord-022353-q2k2krnm	1543	2	 	 	_SP
cord-022353-q2k2krnm	1544	1	TNFRSF	TNFRSF	NNP
cord-022353-q2k2krnm	1544	2	 	 	_SP
cord-022353-q2k2krnm	1545	1	TNFSF	TNFSF	NNP
cord-022353-q2k2krnm	1545	2	 	 	_SP
cord-022353-q2k2krnm	1546	1	TOF	TOF	NNP
cord-022353-q2k2krnm	1546	2	 	 	_SP
cord-022353-q2k2krnm	1547	1	TPC	TPC	NNP
cord-022353-q2k2krnm	1547	2	 	 	_SP
cord-022353-q2k2krnm	1548	1	TRANCE	TRANCE	NNP
cord-022353-q2k2krnm	1548	2	 	 	_SP
cord-022353-q2k2krnm	1549	1	TRH	TRH	NNP
cord-022353-q2k2krnm	1549	2	 	 	_SP
cord-022353-q2k2krnm	1550	1	TSH	TSH	NNP
cord-022353-q2k2krnm	1550	2	 	 	_SP
cord-022353-q2k2krnm	1551	1	TX	TX	NNP
cord-022353-q2k2krnm	1551	2	 	 	_SP
cord-022353-q2k2krnm	1552	1	UPR	UPR	NNP
cord-022353-q2k2krnm	1552	2	 	 	_SP
cord-022353-q2k2krnm	1552	3	USG	USG	NNP
cord-022353-q2k2krnm	1552	4	 	 	_SP
cord-022353-q2k2krnm	1553	1	VLDL	VLDL	NNP
cord-022353-q2k2krnm	1553	2	serum	serum	NN
cord-022353-q2k2krnm	1553	3	amyloid	amyloid	NN
cord-022353-q2k2krnm	1554	1	A	a	DT
cord-022353-q2k2krnm	1554	2	serum	serum	NN
cord-022353-q2k2krnm	1554	3	amyloid	amyloid	NN
cord-022353-q2k2krnm	1554	4	protein	protein	NN
cord-022353-q2k2krnm	1555	1	standard	standard	JJ
cord-022353-q2k2krnm	1555	2	deviation	deviation	NN
cord-022353-q2k2krnm	1555	3	stromal	stromal	JJ
cord-022353-q2k2krnm	1555	4	cell	cell	NN
cord-022353-q2k2krnm	1555	5	-	-	HYPH
cord-022353-q2k2krnm	1555	6	derived	derive	VBN
cord-022353-q2k2krnm	1555	7	factor-1	factor-1	NNP
cord-022353-q2k2krnm	1556	1	sorbitol	sorbitol	NN
cord-022353-q2k2krnm	1556	2	dehydrogenase	dehydrogenase	NN
cord-022353-q2k2krnm	1556	3	surface	surface	NN
cord-022353-q2k2krnm	1556	4	-	-	HYPH
cord-022353-q2k2krnm	1556	5	enhanced	enhance	VBN
cord-022353-q2k2krnm	1556	6	laser	laser	NN
cord-022353-q2k2krnm	1556	7	desorption	desorption	NN
cord-022353-q2k2krnm	1556	8	/	/	SYM
cord-022353-q2k2krnm	1556	9	ionization	ionization	NN
cord-022353-q2k2krnm	1556	10	secondary	secondary	JJ
cord-022353-q2k2krnm	1556	11	lymphoid	lymphoid	JJ
cord-022353-q2k2krnm	1556	12	tissue	tissue	NN
cord-022353-q2k2krnm	1556	13	chemokine	chemokine	NN
cord-022353-q2k2krnm	1557	1	stearoyl	stearoyl	NNP
cord-022353-q2k2krnm	1557	2	-	-	HYPH
cord-022353-q2k2krnm	1557	3	CoA	CoA	NNP
cord-022353-q2k2krnm	1557	4	desaturase-1	desaturase-1	NNP
cord-022353-q2k2krnm	1557	5	suppressor	suppressor	NN
cord-022353-q2k2krnm	1557	6	of	of	IN
cord-022353-q2k2krnm	1557	7	cytokine	cytokine	NN
cord-022353-q2k2krnm	1557	8	signaling-3	signaling-3	NNP
cord-022353-q2k2krnm	1557	9	steroid	steroid	NN
cord-022353-q2k2krnm	1557	10	receptor	receptor	NN
cord-022353-q2k2krnm	1558	1	coactivator-1	coactivator-1	NNP
cord-022353-q2k2krnm	1558	2	Sj6gren	Sj6gren	NNP
cord-022353-q2k2krnm	1558	3	's	's	POS
cord-022353-q2k2krnm	1558	4	syndrome	syndrome	NN
cord-022353-q2k2krnm	1558	5	single	single	JJ
cord-022353-q2k2krnm	1558	6	-	-	HYPH
cord-022353-q2k2krnm	1558	7	strand	strand	NN
cord-022353-q2k2krnm	1558	8	deoxyribonucleic	deoxyribonucleic	NN
cord-022353-q2k2krnm	1558	9	acid	acid	NN
cord-022353-q2k2krnm	1558	10	triiodothyronine	triiodothyronine	NN
cord-022353-q2k2krnm	1558	11	thyroxine	thyroxine	JJ
cord-022353-q2k2krnm	1558	12	tumor	tumor	NN
cord-022353-q2k2krnm	1558	13	necrosis	necrosis	NN
cord-022353-q2k2krnm	1558	14	factor	factor	NN
cord-022353-q2k2krnm	1558	15	-	-	:
cord-022353-q2k2krnm	1558	16	a	a	DT
cord-022353-q2k2krnm	1558	17	converting	convert	VBG
cord-022353-q2k2krnm	1558	18	enzyme	enzyme	NN
cord-022353-q2k2krnm	1558	19	toxicity	toxicity	NN
cord-022353-q2k2krnm	1558	20	and	and	CC
cord-022353-q2k2krnm	1558	21	JNK	JNK	NNP
cord-022353-q2k2krnm	1558	22	inducer	inducer	NN
cord-022353-q2k2krnm	1558	23	cytotoxic	cytotoxic	JJ
cord-022353-q2k2krnm	1558	24	T	t	NN
cord-022353-q2k2krnm	1558	25	-	-	HYPH
cord-022353-q2k2krnm	1558	26	cells	cell	NNS
cord-022353-q2k2krnm	1558	27	triglyceride	triglyceride	NN
cord-022353-q2k2krnm	1558	28	transforming	transform	VBG
cord-022353-q2k2krnm	1558	29	growth	growth	NN
cord-022353-q2k2krnm	1558	30	factor	factor	NN
cord-022353-q2k2krnm	1558	31	-	-	:
cord-022353-q2k2krnm	1558	32	J3	j3	NN
cord-022353-q2k2krnm	1558	33	transforming	transform	VBG
cord-022353-q2k2krnm	1558	34	growth	growth	NN
cord-022353-q2k2krnm	1558	35	factor-13	factor-13	NNS
cord-022353-q2k2krnm	1558	36	superfamily	superfamily	NN
cord-022353-q2k2krnm	1558	37	T	t	NN
cord-022353-q2k2krnm	1558	38	-	-	HYPH
cord-022353-q2k2krnm	1558	39	helper	helper	NN
cord-022353-q2k2krnm	1558	40	Toll	toll	NN
cord-022353-q2k2krnm	1558	41	-	-	HYPH
cord-022353-q2k2krnm	1558	42	like	like	JJ
cord-022353-q2k2krnm	1558	43	receptors	receptor	NNS
cord-022353-q2k2krnm	1558	44	tissue	tissue	VBP
cord-022353-q2k2krnm	1558	45	nonspecific	nonspecific	JJ
cord-022353-q2k2krnm	1558	46	alkaline	alkaline	JJ
cord-022353-q2k2krnm	1558	47	phosphatase	phosphatase	NN
cord-022353-q2k2krnm	1558	48	tumor	tumor	NN
cord-022353-q2k2krnm	1558	49	necrosis	necrosis	NN
cord-022353-q2k2krnm	1558	50	factor	factor	NN
cord-022353-q2k2krnm	1558	51	tumor	tumor	NN
cord-022353-q2k2krnm	1558	52	necrosis	necrosis	NN
cord-022353-q2k2krnm	1558	53	factor	factor	NN
cord-022353-q2k2krnm	1558	54	receptor	receptor	NN
cord-022353-q2k2krnm	1558	55	superfamily	superfamily	NN
cord-022353-q2k2krnm	1558	56	tumor	tumor	NN
cord-022353-q2k2krnm	1558	57	necrosis	necrosis	NN
cord-022353-q2k2krnm	1558	58	factor	factor	NN
cord-022353-q2k2krnm	1558	59	superfamily	superfamily	NN
cord-022353-q2k2krnm	1558	60	time	time	NN
cord-022353-q2k2krnm	1558	61	-	-	HYPH
cord-022353-q2k2krnm	1558	62	of	of	IN
cord-022353-q2k2krnm	1558	63	-	-	HYPH
cord-022353-q2k2krnm	1558	64	flight	flight	NN
cord-022353-q2k2krnm	1558	65	total	total	JJ
cord-022353-q2k2krnm	1558	66	plasma	plasma	NN
cord-022353-q2k2krnm	1558	67	cholesterol	cholesterol	NN
cord-022353-q2k2krnm	1558	68	tumor	tumor	NN
cord-022353-q2k2krnm	1558	69	necrosis	necrosis	NN
cord-022353-q2k2krnm	1558	70	factor	factor	NN
cord-022353-q2k2krnm	1558	71	-	-	HYPH
cord-022353-q2k2krnm	1558	72	related	relate	VBN
cord-022353-q2k2krnm	1558	73	activation	activation	NN
cord-022353-q2k2krnm	1558	74	-	-	HYPH
cord-022353-q2k2krnm	1558	75	induced	induce	VBN
cord-022353-q2k2krnm	1558	76	cytokines	cytokine	NNS
cord-022353-q2k2krnm	1558	77	thyrotropin	thyrotropin	RB
cord-022353-q2k2krnm	1558	78	-	-	HYPH
cord-022353-q2k2krnm	1558	79	releasing	release	VBG
cord-022353-q2k2krnm	1558	80	hormone	hormone	NN
cord-022353-q2k2krnm	1558	81	thyroid	thyroid	NN
cord-022353-q2k2krnm	1558	82	-	-	HYPH
cord-022353-q2k2krnm	1558	83	stimulating	stimulate	VBG
cord-022353-q2k2krnm	1558	84	hormone	hormone	NN
cord-022353-q2k2krnm	1558	85	thromboxane	thromboxane	NN
cord-022353-q2k2krnm	1558	86	unfolded	unfold	VBD
cord-022353-q2k2krnm	1558	87	protein	protein	NN
cord-022353-q2k2krnm	1558	88	response	response	NN
cord-022353-q2k2krnm	1558	89	urine	urine	NN
cord-022353-q2k2krnm	1558	90	specific	specific	JJ
cord-022353-q2k2krnm	1558	91	gravity	gravity	NN
cord-022353-q2k2krnm	1558	92	very	very	RB
cord-022353-q2k2krnm	1558	93	low	low	JJ
cord-022353-q2k2krnm	1558	94	-	-	HYPH
cord-022353-q2k2krnm	1558	95	density	density	NN
cord-022353-q2k2krnm	1558	96	lipoprotein	lipoprotein	NN