id	sid	tid	token	lemma	pos
cord-023417-by18aczt	1	1	key	key	NN
cord-023417-by18aczt	1	2	:	:	:
cord-023417-by18aczt	1	3	cord-023417-by18aczt	cord-023417-by18aczt	NN
cord-023417-by18aczt	1	4	authors	author	NNS
cord-023417-by18aczt	1	5	:	:	:
cord-023417-by18aczt	1	6	Vilhelmsson	Vilhelmsson	NNP
cord-023417-by18aczt	1	7	,	,	,
cord-023417-by18aczt	1	8	M.	M.	NNP
cord-023417-by18aczt	1	9	;	;	:
cord-023417-by18aczt	1	10	Ekman	Ekman	NNP
cord-023417-by18aczt	1	11	,	,	,
cord-023417-by18aczt	1	12	G.	G.	NNP
cord-023417-by18aczt	1	13	J.	J.	NNP
cord-023417-by18aczt	1	14	;	;	:
cord-023417-by18aczt	1	15	Zargari	Zargari	NNP
cord-023417-by18aczt	1	16	,	,	,
cord-023417-by18aczt	1	17	A.	a.	NN
cord-023417-by18aczt	1	18	;	;	:
cord-023417-by18aczt	1	19	Scheynius	Scheynius	NNP
cord-023417-by18aczt	1	20	,	,	,
cord-023417-by18aczt	1	21	A.	a.	NN
cord-023417-by18aczt	1	22	title	title	NN
cord-023417-by18aczt	1	23	:	:	:
cord-023417-by18aczt	2	1	The	the	DT
cord-023417-by18aczt	2	2	Malassezia	Malassezia	NNP
cord-023417-by18aczt	2	3	sympodialis	sympodiali	VBD
cord-023417-by18aczt	2	4	Allergen	Allergen	NNP
cord-023417-by18aczt	2	5	Mala	Mala	NNP
cord-023417-by18aczt	2	6	s	s	POS
cord-023417-by18aczt	2	7	11	11	CD
cord-023417-by18aczt	2	8	with	with	IN
cord-023417-by18aczt	2	9	Sequence	sequence	NN
cord-023417-by18aczt	2	10	Similarity	similarity	NN
cord-023417-by18aczt	2	11	to	to	IN
cord-023417-by18aczt	2	12	Manganese	Manganese	NNP
cord-023417-by18aczt	2	13	Superoxide	Superoxide	NNP
cord-023417-by18aczt	2	14	Dismutase	Dismutase	NNP
cord-023417-by18aczt	2	15	Induces	induce	VBZ
cord-023417-by18aczt	2	16	Maturation	Maturation	NNP
cord-023417-by18aczt	2	17	and	and	CC
cord-023417-by18aczt	2	18	Production	Production	NNP
cord-023417-by18aczt	2	19	of	of	IN
cord-023417-by18aczt	2	20	Inflammatory	Inflammatory	NNP
cord-023417-by18aczt	2	21	Cytokines	Cytokines	NNPS
cord-023417-by18aczt	2	22	in	in	IN
cord-023417-by18aczt	2	23	Human	Human	NNP
cord-023417-by18aczt	2	24	Dendritic	Dendritic	NNP
cord-023417-by18aczt	2	25	Cells	Cells	NNP
cord-023417-by18aczt	2	26	date	date	NN
cord-023417-by18aczt	2	27	:	:	:
cord-023417-by18aczt	2	28	2008	2008	CD
cord-023417-by18aczt	2	29	-	-	SYM
cord-023417-by18aczt	2	30	06	06	CD
cord-023417-by18aczt	2	31	-	-	HYPH
cord-023417-by18aczt	2	32	28	28	CD
cord-023417-by18aczt	2	33	journal	journal	NN
cord-023417-by18aczt	2	34	:	:	:
cord-023417-by18aczt	3	1	Scand	Scand	NNP
cord-023417-by18aczt	3	2	J	J	NNP
cord-023417-by18aczt	3	3	Immunol	Immunol	NNP
cord-023417-by18aczt	3	4	DOI	DOI	NNP
cord-023417-by18aczt	3	5	:	:	:
cord-023417-by18aczt	4	1	10.1111	10.1111	CD
cord-023417-by18aczt	4	2	/	/	SYM
cord-023417-by18aczt	4	3	j.0300	j.0300	NNP
cord-023417-by18aczt	4	4	-	-	HYPH
cord-023417-by18aczt	4	5	9475.2004.01423ae.x	9475.2004.01423ae.x	CD
cord-023417-by18aczt	5	1	sha	sha	NNP
cord-023417-by18aczt	5	2	:	:	:
cord-023417-by18aczt	5	3	c1a352fb40776f1d27a8fbc3a58b0d26b3236df3	c1a352fb40776f1d27a8fbc3a58b0d26b3236df3	NNP
cord-023417-by18aczt	5	4	doc_id	doc_id	CD
cord-023417-by18aczt	5	5	:	:	:
cord-023417-by18aczt	5	6	23417	23417	CD
cord-023417-by18aczt	5	7	cord_uid	cord_uid	NNS
cord-023417-by18aczt	5	8	:	:	:
cord-023417-by18aczt	5	9	by18aczt	by18aczt	NNP
cord-023417-by18aczt	6	1	The	the	DT
cord-023417-by18aczt	6	2	chronic	chronic	JJ
cord-023417-by18aczt	6	3	inflammatory	inflammatory	JJ
cord-023417-by18aczt	6	4	skin	skin	NN
cord-023417-by18aczt	6	5	disease	disease	NN
cord-023417-by18aczt	6	6	atopic	atopic	NN
cord-023417-by18aczt	6	7	eczema	eczema	NN
cord-023417-by18aczt	6	8	(	(	-LRB-
cord-023417-by18aczt	6	9	AE	AE	NNP
cord-023417-by18aczt	6	10	)	)	-RRB-
cord-023417-by18aczt	6	11	affects	affect	VBZ
cord-023417-by18aczt	6	12	almost	almost	RB
cord-023417-by18aczt	6	13	15	15	CD
cord-023417-by18aczt	6	14	%	%	NN
cord-023417-by18aczt	6	15	of	of	IN
cord-023417-by18aczt	6	16	the	the	DT
cord-023417-by18aczt	6	17	population	population	NN
cord-023417-by18aczt	6	18	in	in	IN
cord-023417-by18aczt	6	19	many	many	JJ
cord-023417-by18aczt	6	20	countries	country	NNS
cord-023417-by18aczt	6	21	today	today	NN
cord-023417-by18aczt	6	22	.	.	.
cord-023417-by18aczt	7	1	The	the	DT
cord-023417-by18aczt	7	2	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	7	3	of	of	IN
cord-023417-by18aczt	7	4	AE	AE	NNP
cord-023417-by18aczt	7	5	is	be	VBZ
cord-023417-by18aczt	7	6	not	not	RB
cord-023417-by18aczt	7	7	fully	fully	RB
cord-023417-by18aczt	7	8	understood	understand	VBN
cord-023417-by18aczt	7	9	.	.	.
cord-023417-by18aczt	8	1	A	a	DT
cord-023417-by18aczt	8	2	combination	combination	NN
cord-023417-by18aczt	8	3	of	of	IN
cord-023417-by18aczt	8	4	genetic	genetic	JJ
cord-023417-by18aczt	8	5	predisposition	predisposition	NN
cord-023417-by18aczt	8	6	and	and	CC
cord-023417-by18aczt	8	7	environmental	environmental	JJ
cord-023417-by18aczt	8	8	factors	factor	NNS
cord-023417-by18aczt	8	9	like	like	IN
cord-023417-by18aczt	8	10	microorganisms	microorganism	NNS
cord-023417-by18aczt	8	11	seems	seem	VBZ
cord-023417-by18aczt	8	12	to	to	TO
cord-023417-by18aczt	8	13	contribute	contribute	VB
cord-023417-by18aczt	8	14	to	to	IN
cord-023417-by18aczt	8	15	the	the	DT
cord-023417-by18aczt	8	16	symptoms	symptom	NNS
cord-023417-by18aczt	8	17	.	.	.
cord-023417-by18aczt	9	1	The	the	DT
cord-023417-by18aczt	9	2	yeast	yeast	NN
cord-023417-by18aczt	9	3	Malassezia	Malassezia	NNP
cord-023417-by18aczt	9	4	sympodialis	sympodialis	NNP
cord-023417-by18aczt	9	5	is	be	VBZ
cord-023417-by18aczt	9	6	part	part	NN
cord-023417-by18aczt	9	7	of	of	IN
cord-023417-by18aczt	9	8	our	-PRON-	PRP$
cord-023417-by18aczt	9	9	normal	normal	JJ
cord-023417-by18aczt	9	10	skin	skin	NN
cord-023417-by18aczt	9	11	micro	micro	NN
cord-023417-by18aczt	9	12	flora	flora	NN
cord-023417-by18aczt	9	13	but	but	CC
cord-023417-by18aczt	9	14	can	can	MD
cord-023417-by18aczt	9	15	act	act	VB
cord-023417-by18aczt	9	16	as	as	IN
cord-023417-by18aczt	9	17	an	an	DT
cord-023417-by18aczt	9	18	allergen	allergen	NN
cord-023417-by18aczt	9	19	and	and	CC
cord-023417-by18aczt	9	20	elicit	elicit	VB
cord-023417-by18aczt	9	21	specific	specific	JJ
cord-023417-by18aczt	9	22	IgE	ige	NN
cord-023417-by18aczt	9	23	and	and	CC
cord-023417-by18aczt	9	24	T‐cell	T‐cell	NNP
cord-023417-by18aczt	9	25	reactivity	reactivity	NN
cord-023417-by18aczt	9	26	in	in	IN
cord-023417-by18aczt	9	27	patients	patient	NNS
cord-023417-by18aczt	9	28	with	with	IN
cord-023417-by18aczt	9	29	AE	AE	NNP
cord-023417-by18aczt	9	30	.	.	.
cord-023417-by18aczt	10	1	Recently	recently	RB
cord-023417-by18aczt	10	2	,	,	,
cord-023417-by18aczt	10	3	we	-PRON-	PRP
cord-023417-by18aczt	10	4	identified	identify	VBD
cord-023417-by18aczt	10	5	a	a	DT
cord-023417-by18aczt	10	6	novel	novel	JJ
cord-023417-by18aczt	10	7	major	major	JJ
cord-023417-by18aczt	10	8	M.	M.	NNP
cord-023417-by18aczt	10	9	sympodialis	sympodialis	JJ
cord-023417-by18aczt	10	10	allergen	allergen	NN
cord-023417-by18aczt	10	11	,	,	,
cord-023417-by18aczt	10	12	designated	designate	VBN
cord-023417-by18aczt	10	13	Mala	Mala	NNP
cord-023417-by18aczt	10	14	s	s	POS
cord-023417-by18aczt	10	15	11	11	CD
cord-023417-by18aczt	10	16	(	(	-LRB-
cord-023417-by18aczt	10	17	22.4	22.4	CD
cord-023417-by18aczt	10	18	kDa	kDa	NNPS
cord-023417-by18aczt	10	19	)	)	-RRB-
cord-023417-by18aczt	10	20	,	,	,
cord-023417-by18aczt	10	21	with	with	IN
cord-023417-by18aczt	10	22	sequence	sequence	NN
cord-023417-by18aczt	10	23	similarity	similarity	NN
cord-023417-by18aczt	10	24	to	to	IN
cord-023417-by18aczt	10	25	the	the	DT
cord-023417-by18aczt	10	26	mitochondrial	mitochondrial	JJ
cord-023417-by18aczt	10	27	enzyme	enzyme	NN
cord-023417-by18aczt	10	28	manganese	manganese	NN
cord-023417-by18aczt	10	29	superoxide	superoxide	NN
cord-023417-by18aczt	10	30	dismutase	dismutase	NN
cord-023417-by18aczt	10	31	(	(	-LRB-
cord-023417-by18aczt	10	32	MnSOD	MnSOD	NNP
cord-023417-by18aczt	10	33	)	)	-RRB-
cord-023417-by18aczt	10	34	.	.	.
cord-023417-by18aczt	11	1	Interestingly	interestingly	RB
cord-023417-by18aczt	11	2	,	,	,
cord-023417-by18aczt	11	3	Mala	Mala	NNP
cord-023417-by18aczt	11	4	s	s	POS
cord-023417-by18aczt	11	5	11	11	CD
cord-023417-by18aczt	11	6	has	have	VBZ
cord-023417-by18aczt	11	7	a	a	DT
cord-023417-by18aczt	11	8	high	high	JJ
cord-023417-by18aczt	11	9	degree	degree	NN
cord-023417-by18aczt	11	10	of	of	IN
cord-023417-by18aczt	11	11	homology	homology	NN
cord-023417-by18aczt	11	12	to	to	IN
cord-023417-by18aczt	11	13	human	human	JJ
cord-023417-by18aczt	11	14	MnSOD	MnSOD	NNP
cord-023417-by18aczt	11	15	.	.	.
cord-023417-by18aczt	12	1	The	the	DT
cord-023417-by18aczt	12	2	aim	aim	NN
cord-023417-by18aczt	12	3	of	of	IN
cord-023417-by18aczt	12	4	this	this	DT
cord-023417-by18aczt	12	5	study	study	NN
cord-023417-by18aczt	12	6	was	be	VBD
cord-023417-by18aczt	12	7	to	to	TO
cord-023417-by18aczt	12	8	examine	examine	VB
cord-023417-by18aczt	12	9	the	the	DT
cord-023417-by18aczt	12	10	effects	effect	NNS
cord-023417-by18aczt	12	11	of	of	IN
cord-023417-by18aczt	12	12	recombinant	recombinant	JJ
cord-023417-by18aczt	12	13	Mala	Mala	NNP
cord-023417-by18aczt	12	14	s	s	POS
cord-023417-by18aczt	12	15	11	11	CD
cord-023417-by18aczt	12	16	on	on	IN
cord-023417-by18aczt	12	17	antigen‐presenting	antigen‐presente	VBG
cord-023417-by18aczt	12	18	dendritic	dendritic	JJ
cord-023417-by18aczt	12	19	cells	cell	NNS
cord-023417-by18aczt	12	20	.	.	.
cord-023417-by18aczt	13	1	Monocyte‐derived	monocyte‐derived	JJ
cord-023417-by18aczt	13	2	dendritic	dendritic	JJ
cord-023417-by18aczt	13	3	cells	cell	NNS
cord-023417-by18aczt	13	4	(	(	-LRB-
cord-023417-by18aczt	13	5	MDDCs	mddc	NNS
cord-023417-by18aczt	13	6	)	)	-RRB-
cord-023417-by18aczt	13	7	from	from	IN
cord-023417-by18aczt	13	8	healthy	healthy	JJ
cord-023417-by18aczt	13	9	blood	blood	NN
cord-023417-by18aczt	13	10	donors	donor	NNS
cord-023417-by18aczt	13	11	were	be	VBD
cord-023417-by18aczt	13	12	cultured	culture	VBN
cord-023417-by18aczt	13	13	with	with	IN
cord-023417-by18aczt	13	14	or	or	CC
cord-023417-by18aczt	13	15	without	without	IN
cord-023417-by18aczt	13	16	Mala	Mala	NNP
cord-023417-by18aczt	13	17	s	s	NNP
cord-023417-by18aczt	13	18	11	11	CD
cord-023417-by18aczt	13	19	for	for	IN
cord-023417-by18aczt	13	20	different	different	JJ
cord-023417-by18aczt	13	21	time	time	NN
cord-023417-by18aczt	13	22	periods	period	NNS
cord-023417-by18aczt	13	23	.	.	.
cord-023417-by18aczt	14	1	It	-PRON-	PRP
cord-023417-by18aczt	14	2	was	be	VBD
cord-023417-by18aczt	14	3	found	find	VBN
cord-023417-by18aczt	14	4	that	that	IN
cord-023417-by18aczt	14	5	the	the	DT
cord-023417-by18aczt	14	6	maturation	maturation	NN
cord-023417-by18aczt	14	7	marker	marker	NN
cord-023417-by18aczt	14	8	CD83	CD83	NNP
cord-023417-by18aczt	14	9	and	and	CC
cord-023417-by18aczt	14	10	the	the	DT
cord-023417-by18aczt	14	11	costimulatory	costimulatory	NN
cord-023417-by18aczt	14	12	molecules	molecule	NNS
cord-023417-by18aczt	14	13	CD80	CD80	NNP
cord-023417-by18aczt	14	14	and	and	CC
cord-023417-by18aczt	14	15	CD86	CD86	NNP
cord-023417-by18aczt	14	16	were	be	VBD
cord-023417-by18aczt	14	17	upregulated	upregulate	VBN
cord-023417-by18aczt	14	18	on	on	IN
cord-023417-by18aczt	14	19	the	the	DT
cord-023417-by18aczt	14	20	MDDCs	mddc	NNS
cord-023417-by18aczt	14	21	exposed	expose	VBN
cord-023417-by18aczt	14	22	to	to	IN
cord-023417-by18aczt	14	23	Mala	Mala	NNP
cord-023417-by18aczt	14	24	s	s	NNP
cord-023417-by18aczt	14	25	11	11	CD
cord-023417-by18aczt	14	26	for	for	IN
cord-023417-by18aczt	14	27	24	24	CD
cord-023417-by18aczt	14	28	h	h	NNP
cord-023417-by18aczt	14	29	,	,	,
cord-023417-by18aczt	14	30	as	as	IN
cord-023417-by18aczt	14	31	demonstrated	demonstrate	VBN
cord-023417-by18aczt	14	32	by	by	IN
cord-023417-by18aczt	14	33	flow	flow	NN
cord-023417-by18aczt	14	34	cytometry	cytometry	NN
cord-023417-by18aczt	14	35	.	.	.
cord-023417-by18aczt	15	1	Furthermore	furthermore	RB
cord-023417-by18aczt	15	2	,	,	,
cord-023417-by18aczt	15	3	coculture	coculture	NN
cord-023417-by18aczt	15	4	of	of	IN
cord-023417-by18aczt	15	5	MDDCs	mddc	NNS
cord-023417-by18aczt	15	6	with	with	IN
cord-023417-by18aczt	15	7	Mala	Mala	NNP
cord-023417-by18aczt	15	8	s	s	NNP
cord-023417-by18aczt	15	9	11	11	CD
cord-023417-by18aczt	15	10	for	for	IN
cord-023417-by18aczt	15	11	9	9	CD
cord-023417-by18aczt	15	12	h	h	NN
cord-023417-by18aczt	15	13	induced	induce	VBD
cord-023417-by18aczt	15	14	an	an	DT
cord-023417-by18aczt	15	15	increased	increase	VBN
cord-023417-by18aczt	15	16	production	production	NN
cord-023417-by18aczt	15	17	of	of	IN
cord-023417-by18aczt	15	18	the	the	DT
cord-023417-by18aczt	15	19	inflammatory	inflammatory	JJ
cord-023417-by18aczt	15	20	cytokines	cytokine	NNS
cord-023417-by18aczt	15	21	IL‐6	il‐6	RB
cord-023417-by18aczt	15	22	(	(	-LRB-
cord-023417-by18aczt	15	23	200‐fold	200‐fold	CD
cord-023417-by18aczt	15	24	)	)	-RRB-
cord-023417-by18aczt	15	25	,	,	,
cord-023417-by18aczt	15	26	TNF‐α	TNF‐α	NNP
cord-023417-by18aczt	15	27	(	(	-LRB-
cord-023417-by18aczt	15	28	100‐fold	100‐fold	CD
cord-023417-by18aczt	15	29	)	)	-RRB-
cord-023417-by18aczt	15	30	and	and	CC
cord-023417-by18aczt	15	31	IL‐8	IL‐8	NNP
cord-023417-by18aczt	15	32	(	(	-LRB-
cord-023417-by18aczt	15	33	sixfold	sixfold	RB
cord-023417-by18aczt	15	34	)	)	-RRB-
cord-023417-by18aczt	15	35	,	,	,
cord-023417-by18aczt	15	36	as	as	IN
cord-023417-by18aczt	15	37	detected	detect	VBN
cord-023417-by18aczt	15	38	by	by	IN
cord-023417-by18aczt	15	39	the	the	DT
cord-023417-by18aczt	15	40	cytometric	cytometric	NNP
cord-023417-by18aczt	15	41	bead	bead	NN
cord-023417-by18aczt	15	42	array	array	NN
cord-023417-by18aczt	15	43	(	(	-LRB-
cord-023417-by18aczt	15	44	CBA	CBA	NNP
cord-023417-by18aczt	15	45	)	)	-RRB-
cord-023417-by18aczt	15	46	analysis	analysis	NN
cord-023417-by18aczt	15	47	.	.	.
cord-023417-by18aczt	16	1	Our	-PRON-	PRP$
cord-023417-by18aczt	16	2	results	result	NNS
cord-023417-by18aczt	16	3	suggest	suggest	VBP
cord-023417-by18aczt	16	4	that	that	IN
cord-023417-by18aczt	16	5	Mala	Mala	NNP
cord-023417-by18aczt	16	6	s	s	POS
cord-023417-by18aczt	16	7	11	11	CD
cord-023417-by18aczt	16	8	affects	affect	VBZ
cord-023417-by18aczt	16	9	the	the	DT
cord-023417-by18aczt	16	10	immune	immune	JJ
cord-023417-by18aczt	16	11	response	response	NN
cord-023417-by18aczt	16	12	through	through	IN
cord-023417-by18aczt	16	13	DC	DC	NNP
cord-023417-by18aczt	16	14	maturation	maturation	NN
cord-023417-by18aczt	16	15	and	and	CC
cord-023417-by18aczt	16	16	production	production	NN
cord-023417-by18aczt	16	17	of	of	IN
cord-023417-by18aczt	16	18	inflammatory	inflammatory	JJ
cord-023417-by18aczt	16	19	cytokines	cytokine	NNS
cord-023417-by18aczt	16	20	.	.	.
cord-023417-by18aczt	17	1	The	the	DT
cord-023417-by18aczt	17	2	potential	potential	JJ
cord-023417-by18aczt	17	3	cross‐reactivity	cross‐reactivity	NN
cord-023417-by18aczt	17	4	with	with	IN
cord-023417-by18aczt	17	5	human	human	JJ
cord-023417-by18aczt	17	6	MnSOD	MnSOD	NNP
cord-023417-by18aczt	17	7	needs	need	NNS
cord-023417-by18aczt	17	8	to	to	TO
cord-023417-by18aczt	17	9	be	be	VB
cord-023417-by18aczt	17	10	explored	explore	VBN
cord-023417-by18aczt	17	11	and	and	CC
cord-023417-by18aczt	17	12	the	the	DT
cord-023417-by18aczt	17	13	exact	exact	JJ
cord-023417-by18aczt	17	14	role	role	NN
cord-023417-by18aczt	17	15	of	of	IN
cord-023417-by18aczt	17	16	Mala	Mala	NNP
cord-023417-by18aczt	17	17	s	s	NNP
cord-023417-by18aczt	17	18	11	11	CD
cord-023417-by18aczt	17	19	in	in	IN
cord-023417-by18aczt	17	20	the	the	DT
cord-023417-by18aczt	17	21	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	17	22	of	of	IN
cord-023417-by18aczt	17	23	AE	AE	NNP
cord-023417-by18aczt	17	24	assessed	assess	VBN
cord-023417-by18aczt	17	25	in	in	IN
cord-023417-by18aczt	17	26	clinical	clinical	JJ
cord-023417-by18aczt	17	27	studies	study	NNS
cord-023417-by18aczt	17	28	involving	involve	VBG
cord-023417-by18aczt	17	29	skin	skin	NN
cord-023417-by18aczt	17	30	prick	prick	NN
cord-023417-by18aczt	17	31	and	and	CC
cord-023417-by18aczt	17	32	atopy	atopy	NN
cord-023417-by18aczt	17	33	patch	patch	NN
cord-023417-by18aczt	17	34	tests	test	NNS
cord-023417-by18aczt	17	35	.	.	.
cord-023417-by18aczt	18	1	The	the	DT
cord-023417-by18aczt	18	2	nuclear	nuclear	JJ
cord-023417-by18aczt	18	3	receptor	receptor	NN
cord-023417-by18aczt	18	4	heterodimers	heterodimer	NNS
cord-023417-by18aczt	18	5	of	of	IN
cord-023417-by18aczt	18	6	liver	liver	NN
cord-023417-by18aczt	18	7	X	x	NN
cord-023417-by18aczt	18	8	receptors	receptor	NNS
cord-023417-by18aczt	18	9	(	(	-LRB-
cord-023417-by18aczt	18	10	LXRs	LXRs	NNP
cord-023417-by18aczt	18	11	)	)	-RRB-
cord-023417-by18aczt	18	12	are	be	VBP
cord-023417-by18aczt	18	13	recently	recently	RB
cord-023417-by18aczt	18	14	identified	identify	VBN
cord-023417-by18aczt	18	15	as	as	IN
cord-023417-by18aczt	18	16	key	key	JJ
cord-023417-by18aczt	18	17	transcriptional	transcriptional	JJ
cord-023417-by18aczt	18	18	regulators	regulator	NNS
cord-023417-by18aczt	18	19	of	of	IN
cord-023417-by18aczt	18	20	genes	gene	NNS
cord-023417-by18aczt	18	21	involved	involve	VBN
cord-023417-by18aczt	18	22	in	in	IN
cord-023417-by18aczt	18	23	lipid	lipid	NN
cord-023417-by18aczt	18	24	homeostasis	homeostasis	NN
cord-023417-by18aczt	18	25	and	and	CC
cord-023417-by18aczt	18	26	inflammation	inflammation	NN
cord-023417-by18aczt	18	27	.	.	.
cord-023417-by18aczt	19	1	LXRs	LXRs	NNP
cord-023417-by18aczt	19	2	and	and	CC
cord-023417-by18aczt	19	3	their	-PRON-	PRP$
cord-023417-by18aczt	19	4	ligands	ligand	NNS
cord-023417-by18aczt	19	5	are	be	VBP
cord-023417-by18aczt	19	6	negative	negative	JJ
cord-023417-by18aczt	19	7	regulators	regulator	NNS
cord-023417-by18aczt	19	8	of	of	IN
cord-023417-by18aczt	19	9	macrophage	macrophage	NN
cord-023417-by18aczt	19	10	inflammatory	inflammatory	JJ
cord-023417-by18aczt	19	11	gene	gene	NN
cord-023417-by18aczt	19	12	expression	expression	NN
cord-023417-by18aczt	19	13	.	.	.
cord-023417-by18aczt	20	1	Multiple	multiple	JJ
cord-023417-by18aczt	20	2	sclerosis	sclerosis	NN
cord-023417-by18aczt	20	3	(	(	-LRB-
cord-023417-by18aczt	20	4	MS	MS	NNP
cord-023417-by18aczt	20	5	)	)	-RRB-
cord-023417-by18aczt	20	6	,	,	,
cord-023417-by18aczt	20	7	a	a	DT
cord-023417-by18aczt	20	8	demyelinating	demyelinating	JJ
cord-023417-by18aczt	20	9	disease	disease	NN
cord-023417-by18aczt	20	10	of	of	IN
cord-023417-by18aczt	20	11	the	the	DT
cord-023417-by18aczt	20	12	central	central	JJ
cord-023417-by18aczt	20	13	nervous	nervous	JJ
cord-023417-by18aczt	20	14	system	system	NN
cord-023417-by18aczt	20	15	of	of	IN
cord-023417-by18aczt	20	16	unknown	unknown	JJ
cord-023417-by18aczt	20	17	cause	cause	NN
cord-023417-by18aczt	20	18	,	,	,
cord-023417-by18aczt	20	19	is	be	VBZ
cord-023417-by18aczt	20	20	characterized	characterize	VBN
cord-023417-by18aczt	20	21	by	by	IN
cord-023417-by18aczt	20	22	recurrent	recurrent	JJ
cord-023417-by18aczt	20	23	inflammation	inflammation	NN
cord-023417-by18aczt	20	24	involving	involve	VBG
cord-023417-by18aczt	20	25	macrophages	macrophage	NNS
cord-023417-by18aczt	20	26	and	and	CC
cord-023417-by18aczt	20	27	their	-PRON-	PRP$
cord-023417-by18aczt	20	28	inflammatory	inflammatory	JJ
cord-023417-by18aczt	20	29	mediators	mediator	NNS
cord-023417-by18aczt	20	30	.	.	.
cord-023417-by18aczt	21	1	Sweden	Sweden	NNP
cord-023417-by18aczt	21	2	belongs	belong	VBZ
cord-023417-by18aczt	21	3	to	to	IN
cord-023417-by18aczt	21	4	the	the	DT
cord-023417-by18aczt	21	5	countries	country	NNS
cord-023417-by18aczt	21	6	with	with	IN
cord-023417-by18aczt	21	7	a	a	DT
cord-023417-by18aczt	21	8	high	high	JJ
cord-023417-by18aczt	21	9	MS	MS	NNP
cord-023417-by18aczt	21	10	incidence	incidence	NN
cord-023417-by18aczt	21	11	.	.	.
cord-023417-by18aczt	22	1	In	in	IN
cord-023417-by18aczt	22	2	Italy	Italy	NNP
cord-023417-by18aczt	22	3	,	,	,
cord-023417-by18aczt	22	4	incidence	incidence	NN
cord-023417-by18aczt	22	5	is	be	VBZ
cord-023417-by18aczt	22	6	lower	low	JJR
cord-023417-by18aczt	22	7	,	,	,
cord-023417-by18aczt	22	8	with	with	IN
cord-023417-by18aczt	22	9	an	an	DT
cord-023417-by18aczt	22	10	exception	exception	NN
cord-023417-by18aczt	22	11	for	for	IN
cord-023417-by18aczt	22	12	Sardinia	Sardinia	NNP
cord-023417-by18aczt	22	13	where	where	WRB
cord-023417-by18aczt	22	14	the	the	DT
cord-023417-by18aczt	22	15	incidence	incidence	NN
cord-023417-by18aczt	22	16	is	be	VBZ
cord-023417-by18aczt	22	17	even	even	RB
cord-023417-by18aczt	22	18	higher	high	JJR
cord-023417-by18aczt	22	19	than	than	IN
cord-023417-by18aczt	22	20	that	that	DT
cord-023417-by18aczt	22	21	in	in	IN
cord-023417-by18aczt	22	22	Sweden	Sweden	NNP
cord-023417-by18aczt	22	23	.	.	.
cord-023417-by18aczt	23	1	Subjects	subject	NNS
cord-023417-by18aczt	23	2	from	from	IN
cord-023417-by18aczt	23	3	Sardinia	Sardinia	NNP
cord-023417-by18aczt	23	4	are	be	VBP
cord-023417-by18aczt	23	5	ethnically	ethnically	RB
cord-023417-by18aczt	23	6	more	more	RBR
cord-023417-by18aczt	23	7	homogeneous	homogeneous	JJ
cord-023417-by18aczt	23	8	and	and	CC
cord-023417-by18aczt	23	9	differ	differ	VBP
cord-023417-by18aczt	23	10	from	from	IN
cord-023417-by18aczt	23	11	Swedes	Swedes	NNPS
cord-023417-by18aczt	23	12	,	,	,
cord-023417-by18aczt	23	13	also	also	RB
cord-023417-by18aczt	23	14	regarding	regard	VBG
cord-023417-by18aczt	23	15	genetic	genetic	JJ
cord-023417-by18aczt	23	16	background	background	NN
cord-023417-by18aczt	23	17	and	and	CC
cord-023417-by18aczt	23	18	environment	environment	NN
cord-023417-by18aczt	23	19	.	.	.
cord-023417-by18aczt	24	1	We	-PRON-	PRP
cord-023417-by18aczt	24	2	studied	study	VBD
cord-023417-by18aczt	24	3	LXRs	lxr	NNS
cord-023417-by18aczt	24	4	and	and	CC
cord-023417-by18aczt	24	5	their	-PRON-	PRP$
cord-023417-by18aczt	24	6	related	related	JJ
cord-023417-by18aczt	24	7	molecules	molecule	NNS
cord-023417-by18aczt	24	8	of	of	IN
cord-023417-by18aczt	24	9	blood	blood	NN
cord-023417-by18aczt	24	10	mononuclear	mononuclear	NN
cord-023417-by18aczt	24	11	cells	cell	NNS
cord-023417-by18aczt	24	12	(	(	-LRB-
cord-023417-by18aczt	24	13	MNCs	mnc	NNS
cord-023417-by18aczt	24	14	)	)	-RRB-
cord-023417-by18aczt	24	15	from	from	IN
cord-023417-by18aczt	24	16	female	female	JJ
cord-023417-by18aczt	24	17	patients	patient	NNS
cord-023417-by18aczt	24	18	with	with	IN
cord-023417-by18aczt	24	19	untreated	untreated	JJ
cord-023417-by18aczt	24	20	relapsing	relapse	VBG
cord-023417-by18aczt	24	21	-	-	HYPH
cord-023417-by18aczt	24	22	remitting	remit	VBG
cord-023417-by18aczt	24	23	MS	MS	NNP
cord-023417-by18aczt	24	24	from	from	IN
cord-023417-by18aczt	24	25	Sassari	Sassari	NNP
cord-023417-by18aczt	24	26	,	,	,
cord-023417-by18aczt	24	27	Sardinia	Sardinia	NNP
cord-023417-by18aczt	24	28	and	and	CC
cord-023417-by18aczt	24	29	Stockholm	Stockholm	NNP
cord-023417-by18aczt	24	30	,	,	,
cord-023417-by18aczt	24	31	Sweden	Sweden	NNP
cord-023417-by18aczt	24	32	.	.	.
cord-023417-by18aczt	25	1	Sex	sex	NN
cord-023417-by18aczt	25	2	-	-	HYPH
cord-023417-by18aczt	25	3	and	and	CC
cord-023417-by18aczt	25	4	age	age	NN
cord-023417-by18aczt	25	5	-	-	HYPH
cord-023417-by18aczt	25	6	matched	match	VBN
cord-023417-by18aczt	25	7	healthy	healthy	JJ
cord-023417-by18aczt	25	8	controls	control	NNS
cord-023417-by18aczt	25	9	(	(	-LRB-
cord-023417-by18aczt	25	10	HCs	HCs	NNP
cord-023417-by18aczt	25	11	)	)	-RRB-
cord-023417-by18aczt	25	12	were	be	VBD
cord-023417-by18aczt	25	13	from	from	IN
cord-023417-by18aczt	25	14	both	both	DT
cord-023417-by18aczt	25	15	areas	area	NNS
cord-023417-by18aczt	25	16	.	.	.
cord-023417-by18aczt	26	1	mRNA	mRNA	NNP
cord-023417-by18aczt	26	2	expression	expression	NN
cord-023417-by18aczt	26	3	was	be	VBD
cord-023417-by18aczt	26	4	evaluated	evaluate	VBN
cord-023417-by18aczt	26	5	by	by	IN
cord-023417-by18aczt	26	6	real	real	JJ
cord-023417-by18aczt	26	7	-	-	HYPH
cord-023417-by18aczt	26	8	time	time	NN
cord-023417-by18aczt	26	9	PCR	PCR	NNP
cord-023417-by18aczt	26	10	.	.	.
cord-023417-by18aczt	27	1	LXR	LXR	NNP
cord-023417-by18aczt	27	2	-	-	:
cord-023417-by18aczt	27	3	a	a	NNP
cord-023417-by18aczt	27	4	was	be	VBD
cord-023417-by18aczt	27	5	lower	low	JJR
cord-023417-by18aczt	28	1	(	(	-LRB-
cord-023417-by18aczt	28	2	P	p	NN
cord-023417-by18aczt	28	3	<	<	XX
cord-023417-by18aczt	28	4	0.05	0.05	CD
cord-023417-by18aczt	28	5	)	)	-RRB-
cord-023417-by18aczt	28	6	in	in	IN
cord-023417-by18aczt	28	7	MS	MS	NNP
cord-023417-by18aczt	29	1	(	(	-LRB-
cord-023417-by18aczt	29	2	mean	mean	VB
cord-023417-by18aczt	29	3	AE	AE	NNP
cord-023417-by18aczt	29	4	SEM	SEM	NNP
cord-023417-by18aczt	29	5	:	:	:
cord-023417-by18aczt	29	6	3.1	3.1	CD
cord-023417-by18aczt	29	7	AE	AE	NNP
cord-023417-by18aczt	29	8	0.2	0.2	CD
cord-023417-by18aczt	29	9	;	;	:
cord-023417-by18aczt	30	1	n	n	NNP
cord-023417-by18aczt	30	2	¼	¼	NNP
cord-023417-by18aczt	30	3	37	37	CD
cord-023417-by18aczt	30	4	)	)	-RRB-
cord-023417-by18aczt	30	5	compared	compare	VBN
cord-023417-by18aczt	30	6	to	to	IN
cord-023417-by18aczt	30	7	HC	HC	NNP
cord-023417-by18aczt	30	8	(	(	-LRB-
cord-023417-by18aczt	30	9	3.6	3.6	CD
cord-023417-by18aczt	30	10	AE	AE	NNP
cord-023417-by18aczt	30	11	0.1	0.1	CD
cord-023417-by18aczt	30	12	;	;	:
cord-023417-by18aczt	30	13	n	n	NN
cord-023417-by18aczt	30	14	¼	¼	NNP
cord-023417-by18aczt	30	15	37	37	CD
cord-023417-by18aczt	30	16	)	)	-RRB-
cord-023417-by18aczt	30	17	.	.	.
cord-023417-by18aczt	31	1	LXR	LXR	NNP
cord-023417-by18aczt	31	2	-	-	:
cord-023417-by18aczt	31	3	a	a	NNP
cord-023417-by18aczt	31	4	was	be	VBD
cord-023417-by18aczt	31	5	lower	low	JJR
cord-023417-by18aczt	31	6	in	in	IN
cord-023417-by18aczt	31	7	MS	MS	NNP
cord-023417-by18aczt	31	8	from	from	IN
cord-023417-by18aczt	31	9	Stockholm	Stockholm	NNP
cord-023417-by18aczt	31	10	(	(	-LRB-
cord-023417-by18aczt	31	11	2.6	2.6	CD
cord-023417-by18aczt	31	12	AE	AE	NNP
cord-023417-by18aczt	31	13	0.2	0.2	CD
cord-023417-by18aczt	31	14	;	;	:
cord-023417-by18aczt	31	15	n	n	NN
cord-023417-by18aczt	31	16	¼	¼	NNP
cord-023417-by18aczt	31	17	22	22	CD
cord-023417-by18aczt	31	18	)	)	-RRB-
cord-023417-by18aczt	31	19	compared	compare	VBN
cord-023417-by18aczt	31	20	to	to	IN
cord-023417-by18aczt	31	21	corresponding	correspond	VBG
cord-023417-by18aczt	31	22	HC	HC	NNP
cord-023417-by18aczt	31	23	(	(	-LRB-
cord-023417-by18aczt	31	24	3.4	3.4	CD
cord-023417-by18aczt	31	25	AE	AE	NNP
cord-023417-by18aczt	31	26	0.1	0.1	CD
cord-023417-by18aczt	31	27	;	;	:
cord-023417-by18aczt	31	28	n	n	NN
cord-023417-by18aczt	31	29	¼	¼	NNP
cord-023417-by18aczt	31	30	22	22	CD
cord-023417-by18aczt	31	31	;	;	:
cord-023417-by18aczt	31	32	P	p	NN
cord-023417-by18aczt	31	33	<	<	XX
cord-023417-by18aczt	31	34	0.01	0.01	CD
cord-023417-by18aczt	31	35	)	)	-RRB-
cord-023417-by18aczt	31	36	and	and	CC
cord-023417-by18aczt	31	37	compared	compare	VBN
cord-023417-by18aczt	31	38	to	to	IN
cord-023417-by18aczt	31	39	MS	MS	NNP
cord-023417-by18aczt	31	40	(	(	-LRB-
cord-023417-by18aczt	31	41	3.8	3.8	CD
cord-023417-by18aczt	31	42	AE	AE	NNP
cord-023417-by18aczt	31	43	0.2	0.2	CD
cord-023417-by18aczt	31	44	;	;	:
cord-023417-by18aczt	31	45	n	n	NN
cord-023417-by18aczt	31	46	¼	¼	NNP
cord-023417-by18aczt	31	47	15	15	CD
cord-023417-by18aczt	31	48	;	;	:
cord-023417-by18aczt	31	49	P	p	NN
cord-023417-by18aczt	31	50	<	<	XX
cord-023417-by18aczt	31	51	0.001	0.001	CD
cord-023417-by18aczt	31	52	)	)	-RRB-
cord-023417-by18aczt	31	53	and	and	CC
cord-023417-by18aczt	31	54	HC	HC	NNP
cord-023417-by18aczt	31	55	(	(	-LRB-
cord-023417-by18aczt	31	56	4	4	CD
cord-023417-by18aczt	31	57	AE	AE	NNP
cord-023417-by18aczt	31	58	0.2	0.2	CD
cord-023417-by18aczt	31	59	;	;	:
cord-023417-by18aczt	31	60	n	n	NN
cord-023417-by18aczt	31	61	¼	¼	NNP
cord-023417-by18aczt	31	62	15	15	CD
cord-023417-by18aczt	31	63	;	;	:
cord-023417-by18aczt	31	64	P	p	NN
cord-023417-by18aczt	31	65	<	<	XX
cord-023417-by18aczt	31	66	0.001	0.001	CD
cord-023417-by18aczt	31	67	)	)	-RRB-
cord-023417-by18aczt	31	68	from	from	IN
cord-023417-by18aczt	31	69	Sardinia	Sardinia	NNP
cord-023417-by18aczt	31	70	.	.	.
cord-023417-by18aczt	32	1	MS	MS	NNP
cord-023417-by18aczt	32	2	patients	patient	NNS
cord-023417-by18aczt	32	3	from	from	IN
cord-023417-by18aczt	32	4	Stockholm	Stockholm	NNP
cord-023417-by18aczt	32	5	,	,	,
cord-023417-by18aczt	32	6	but	but	CC
cord-023417-by18aczt	32	7	not	not	RB
cord-023417-by18aczt	32	8	from	from	IN
cord-023417-by18aczt	32	9	Sassari	Sassari	NNP
cord-023417-by18aczt	32	10	,	,	,
cord-023417-by18aczt	32	11	also	also	RB
cord-023417-by18aczt	32	12	expressed	express	VBD
cord-023417-by18aczt	32	13	lower	low	JJR
cord-023417-by18aczt	32	14	(	(	-LRB-
cord-023417-by18aczt	32	15	P	p	NN
cord-023417-by18aczt	32	16	<	<	XX
cord-023417-by18aczt	32	17	0.05	0.05	CD
cord-023417-by18aczt	32	18	)	)	-RRB-
cord-023417-by18aczt	33	1	LXR	LXR	NNP
cord-023417-by18aczt	33	2	-	-	HYPH
cord-023417-by18aczt	33	3	b	b	NNP
cord-023417-by18aczt	33	4	(	(	-LRB-
cord-023417-by18aczt	33	5	À4.1	À4.1	NNP
cord-023417-by18aczt	33	6	AE	AE	NNP
cord-023417-by18aczt	33	7	0.4	0.4	CD
cord-023417-by18aczt	33	8	)	)	-RRB-
cord-023417-by18aczt	34	1	compared	compare	VBN
cord-023417-by18aczt	34	2	to	to	IN
cord-023417-by18aczt	34	3	corresponding	correspond	VBG
cord-023417-by18aczt	34	4	HC	HC	NNP
cord-023417-by18aczt	34	5	(	(	-LRB-
cord-023417-by18aczt	34	6	À2.9	À2.9	NNP
cord-023417-by18aczt	34	7	AE	AE	NNP
cord-023417-by18aczt	34	8	0.3	0.3	CD
cord-023417-by18aczt	34	9	)	)	-RRB-
cord-023417-by18aczt	34	10	.	.	.
cord-023417-by18aczt	35	1	MS	MS	NNP
cord-023417-by18aczt	35	2	from	from	IN
cord-023417-by18aczt	35	3	Stockholm	Stockholm	NNP
cord-023417-by18aczt	35	4	was	be	VBD
cord-023417-by18aczt	35	5	associated	associate	VBN
cord-023417-by18aczt	35	6	with	with	IN
cord-023417-by18aczt	35	7	higher	high	JJR
cord-023417-by18aczt	35	8	ABCA-1	ABCA-1	NNP
cord-023417-by18aczt	35	9	(	(	-LRB-
cord-023417-by18aczt	35	10	6.1	6.1	CD
cord-023417-by18aczt	35	11	AE	AE	NNP
cord-023417-by18aczt	35	12	0.4	0.4	CD
cord-023417-by18aczt	35	13	versus	versus	IN
cord-023417-by18aczt	35	14	5.0	5.0	CD
cord-023417-by18aczt	35	15	AE	AE	NNP
cord-023417-by18aczt	35	16	0.3	0.3	CD
cord-023417-by18aczt	35	17	;	;	:
cord-023417-by18aczt	35	18	P	p	NN
cord-023417-by18aczt	35	19	<	<	XX
cord-023417-by18aczt	35	20	0.05	0.05	CD
cord-023417-by18aczt	35	21	)	)	-RRB-
cord-023417-by18aczt	35	22	and	and	CC
cord-023417-by18aczt	35	23	higher	high	JJR
cord-023417-by18aczt	35	24	estrogen	estrogen	NN
cord-023417-by18aczt	35	25	receptor	receptor	NN
cord-023417-by18aczt	35	26	-	-	HYPH
cord-023417-by18aczt	35	27	b	b	NN
cord-023417-by18aczt	35	28	-	-	HYPH
cord-023417-by18aczt	35	29	Cx	cx	NN
cord-023417-by18aczt	35	30	(	(	-LRB-
cord-023417-by18aczt	35	31	2.4	2.4	CD
cord-023417-by18aczt	35	32	AE	AE	NNP
cord-023417-by18aczt	35	33	0.4	0.4	CD
cord-023417-by18aczt	35	34	versus	versus	IN
cord-023417-by18aczt	35	35	0.8	0.8	CD
cord-023417-by18aczt	35	36	AE	AE	NNP
cord-023417-by18aczt	35	37	0.4	0.4	CD
cord-023417-by18aczt	35	38	;	;	:
cord-023417-by18aczt	35	39	P	p	NN
cord-023417-by18aczt	35	40	<	<	XX
cord-023417-by18aczt	35	41	0.01	0.01	CD
cord-023417-by18aczt	35	42	)	)	-RRB-
cord-023417-by18aczt	35	43	compared	compare	VBN
cord-023417-by18aczt	35	44	to	to	IN
cord-023417-by18aczt	35	45	corresponding	correspond	VBG
cord-023417-by18aczt	35	46	HC	HC	NNP
cord-023417-by18aczt	35	47	.	.	.
cord-023417-by18aczt	36	1	The	the	DT
cord-023417-by18aczt	36	2	HC	HC	NNP
cord-023417-by18aczt	36	3	from	from	IN
cord-023417-by18aczt	36	4	Sassari	Sassari	NNP
cord-023417-by18aczt	36	5	had	have	VBD
cord-023417-by18aczt	36	6	higher	high	JJR
cord-023417-by18aczt	36	7	androgen	androgen	NN
cord-023417-by18aczt	36	8	receptor	receptor	NN
cord-023417-by18aczt	36	9	(	(	-LRB-
cord-023417-by18aczt	36	10	2.9	2.9	CD
cord-023417-by18aczt	36	11	AE	AE	NNP
cord-023417-by18aczt	36	12	0.2	0.2	CD
cord-023417-by18aczt	36	13	)	)	-RRB-
cord-023417-by18aczt	36	14	compared	compare	VBN
cord-023417-by18aczt	36	15	to	to	IN
cord-023417-by18aczt	36	16	MS	MS	NNP
cord-023417-by18aczt	36	17	from	from	IN
cord-023417-by18aczt	36	18	Sassari	Sassari	NNP
cord-023417-by18aczt	36	19	(	(	-LRB-
cord-023417-by18aczt	36	20	1.4	1.4	CD
cord-023417-by18aczt	36	21	AE	AE	NNP
cord-023417-by18aczt	36	22	0.3	0.3	CD
cord-023417-by18aczt	36	23	;	;	:
cord-023417-by18aczt	36	24	P	p	NN
cord-023417-by18aczt	36	25	<	<	XX
cord-023417-by18aczt	36	26	0.01	0.01	CD
cord-023417-by18aczt	36	27	)	)	-RRB-
cord-023417-by18aczt	36	28	,	,	,
cord-023417-by18aczt	36	29	MS	MS	NNP
cord-023417-by18aczt	36	30	(	(	-LRB-
cord-023417-by18aczt	36	31	1.3	1.3	CD
cord-023417-by18aczt	36	32	AE	AE	NNP
cord-023417-by18aczt	36	33	0.4	0.4	CD
cord-023417-by18aczt	36	34	;	;	:
cord-023417-by18aczt	36	35	P	p	NN
cord-023417-by18aczt	36	36	<	<	XX
cord-023417-by18aczt	36	37	0.01	0.01	CD
cord-023417-by18aczt	36	38	)	)	-RRB-
cord-023417-by18aczt	36	39	and	and	CC
cord-023417-by18aczt	36	40	HC	HC	NNP
cord-023417-by18aczt	36	41	from	from	IN
cord-023417-by18aczt	36	42	Stockholm	Stockholm	NNP
cord-023417-by18aczt	36	43	(	(	-LRB-
cord-023417-by18aczt	36	44	1.2	1.2	CD
cord-023417-by18aczt	36	45	AE	AE	NNP
cord-023417-by18aczt	36	46	0.3	0.3	CD
cord-023417-by18aczt	36	47	;	;	:
cord-023417-by18aczt	36	48	P	p	NN
cord-023417-by18aczt	36	49	<	<	XX
cord-023417-by18aczt	36	50	0.01	0.01	CD
cord-023417-by18aczt	36	51	)	)	-RRB-
cord-023417-by18aczt	36	52	.	.	.
cord-023417-by18aczt	37	1	MS	MS	NNP
cord-023417-by18aczt	37	2	from	from	IN
cord-023417-by18aczt	37	3	Sassari	Sassari	NNP
cord-023417-by18aczt	37	4	had	have	VBD
cord-023417-by18aczt	37	5	lower	low	JJR
cord-023417-by18aczt	37	6	cyclooxygenase-1	cyclooxygenase-1	NN
cord-023417-by18aczt	37	7	compared	compare	VBN
cord-023417-by18aczt	37	8	to	to	IN
cord-023417-by18aczt	37	9	corresponding	correspond	VBG
cord-023417-by18aczt	37	10	HC	HC	NNP
cord-023417-by18aczt	37	11	(	(	-LRB-
cord-023417-by18aczt	37	12	5.1	5.1	CD
cord-023417-by18aczt	37	13	AE	AE	NNP
cord-023417-by18aczt	37	14	0.4	0.4	CD
cord-023417-by18aczt	37	15	versus	versus	IN
cord-023417-by18aczt	37	16	6.6	6.6	CD
cord-023417-by18aczt	37	17	AE	AE	NNP
cord-023417-by18aczt	37	18	0.3	0.3	CD
cord-023417-by18aczt	37	19	;	;	:
cord-023417-by18aczt	37	20	P	p	NN
cord-023417-by18aczt	37	21	<	<	XX
cord-023417-by18aczt	37	22	0.01	0.01	CD
cord-023417-by18aczt	37	23	)	)	-RRB-
cord-023417-by18aczt	37	24	and	and	CC
cord-023417-by18aczt	37	25	lower	low	JJR
cord-023417-by18aczt	37	26	prostaglandin	prostaglandin	NN
cord-023417-by18aczt	37	27	-	-	HYPH
cord-023417-by18aczt	37	28	E	e	NN
cord-023417-by18aczt	37	29	(	(	-LRB-
cord-023417-by18aczt	37	30	À0.03	À0.03	NNP
cord-023417-by18aczt	37	31	AE	AE	NNP
cord-023417-by18aczt	37	32	0.5	0.5	CD
cord-023417-by18aczt	37	33	)	)	-RRB-
cord-023417-by18aczt	37	34	compared	compare	VBN
cord-023417-by18aczt	37	35	to	to	IN
cord-023417-by18aczt	37	36	the	the	DT
cord-023417-by18aczt	37	37	HC	HC	NNP
cord-023417-by18aczt	37	38	(	(	-LRB-
cord-023417-by18aczt	37	39	1.4	1.4	CD
cord-023417-by18aczt	37	40	AE	AE	NNP
cord-023417-by18aczt	37	41	0.5	0.5	CD
cord-023417-by18aczt	37	42	;	;	:
cord-023417-by18aczt	37	43	P	p	NN
cord-023417-by18aczt	37	44	<	<	XX
cord-023417-by18aczt	37	45	0.05	0.05	CD
cord-023417-by18aczt	37	46	)	)	-RRB-
cord-023417-by18aczt	37	47	and	and	CC
cord-023417-by18aczt	37	48	MS	MS	NNP
cord-023417-by18aczt	37	49	(	(	-LRB-
cord-023417-by18aczt	37	50	2.7	2.7	CD
cord-023417-by18aczt	37	51	AE	AE	NNP
cord-023417-by18aczt	37	52	0.4	0.4	CD
cord-023417-by18aczt	37	53	;	;	:
cord-023417-by18aczt	37	54	P	p	NN
cord-023417-by18aczt	37	55	<	<	XX
cord-023417-by18aczt	37	56	0.05	0.05	CD
cord-023417-by18aczt	37	57	)	)	-RRB-
cord-023417-by18aczt	37	58	and	and	CC
cord-023417-by18aczt	37	59	HC	HC	NNP
cord-023417-by18aczt	37	60	from	from	IN
cord-023417-by18aczt	37	61	Stockholm	Stockholm	NNP
cord-023417-by18aczt	37	62	(	(	-LRB-
cord-023417-by18aczt	37	63	1.9	1.9	CD
cord-023417-by18aczt	37	64	AE	AE	NNP
cord-023417-by18aczt	37	65	0.4	0.4	CD
cord-023417-by18aczt	37	66	,	,	,
cord-023417-by18aczt	37	67	P	p	NN
cord-023417-by18aczt	37	68	<	<	XX
cord-023417-by18aczt	37	69	0.001	0.001	CD
cord-023417-by18aczt	37	70	)	)	-RRB-
cord-023417-by18aczt	37	71	.	.	.
cord-023417-by18aczt	38	1	Our	-PRON-	PRP$
cord-023417-by18aczt	38	2	findings	finding	NNS
cord-023417-by18aczt	38	3	identify	identify	VBP
cord-023417-by18aczt	38	4	LXRs	lxr	NNS
cord-023417-by18aczt	38	5	and	and	CC
cord-023417-by18aczt	38	6	their	-PRON-	PRP$
cord-023417-by18aczt	38	7	related	related	JJ
cord-023417-by18aczt	38	8	molecules	molecule	NNS
cord-023417-by18aczt	38	9	as	as	IN
cord-023417-by18aczt	38	10	being	be	VBG
cord-023417-by18aczt	38	11	involved	involve	VBN
cord-023417-by18aczt	38	12	in	in	IN
cord-023417-by18aczt	38	13	MS	MS	NNP
cord-023417-by18aczt	38	14	from	from	IN
cord-023417-by18aczt	38	15	Stockholm	Stockholm	NNP
cord-023417-by18aczt	38	16	but	but	CC
cord-023417-by18aczt	38	17	not	not	RB
cord-023417-by18aczt	38	18	from	from	IN
cord-023417-by18aczt	38	19	Sassari	Sassari	NNP
cord-023417-by18aczt	38	20	,	,	,
cord-023417-by18aczt	38	21	while	while	IN
cord-023417-by18aczt	38	22	sex	sex	NN
cord-023417-by18aczt	38	23	hormone	hormone	NN
cord-023417-by18aczt	38	24	receptors	receptor	NNS
cord-023417-by18aczt	38	25	seem	seem	VBP
cord-023417-by18aczt	38	26	to	to	TO
cord-023417-by18aczt	38	27	be	be	VB
cord-023417-by18aczt	38	28	involved	involve	VBN
cord-023417-by18aczt	38	29	in	in	IN
cord-023417-by18aczt	38	30	MS	MS	NNP
cord-023417-by18aczt	38	31	in	in	IN
cord-023417-by18aczt	38	32	Sassari	Sassari	NNP
cord-023417-by18aczt	38	33	.	.	.
cord-023417-by18aczt	39	1	Multiple	multiple	JJ
cord-023417-by18aczt	39	2	Sclerosis	Sclerosis	NNP
cord-023417-by18aczt	39	3	:	:	:
cord-023417-by18aczt	39	4	IFN	IFN	NNP
cord-023417-by18aczt	39	5	-	-	HYPH
cord-023417-by18aczt	39	6	b	b	NNP
cord-023417-by18aczt	39	7	Induces	induce	VBZ
cord-023417-by18aczt	40	1	CD123	CD123	NNP
cord-023417-by18aczt	40	2	+	+	CC
cord-023417-by18aczt	41	1	BDCA2	BDCA2	NNP
cord-023417-by18aczt	41	2	-Dendritic	-Dendritic	NNP
cord-023417-by18aczt	42	1	Cells	cell	NNS
cord-023417-by18aczt	43	1	that	that	DT
cord-023417-by18aczt	43	2	Produce	Produce	NNP
cord-023417-by18aczt	43	3	IL-6	IL-6	NNP
cord-023417-by18aczt	43	4	and	and	CC
cord-023417-by18aczt	43	5	IL-10	IL-10	NNP
cord-023417-by18aczt	43	6	and	and	CC
cord-023417-by18aczt	43	7	have	have	VBP
cord-023417-by18aczt	43	8	No	no	DT
cord-023417-by18aczt	43	9	Enhanced	Enhanced	NNP
cord-023417-by18aczt	43	10	Type	type	NN
cord-023417-by18aczt	44	1	I	-PRON-	PRP
cord-023417-by18aczt	45	1	Interferon	Interferon	NNP
cord-023417-by18aczt	45	2	Production	Production	NNP
cord-023417-by18aczt	45	3	Y.	Y.	NNP
cord-023417-by18aczt	45	4	M.	M.	NNP
cord-023417-by18aczt	45	5	Huang	Huang	NNP
cord-023417-by18aczt	45	6	,	,	,
cord-023417-by18aczt	45	7	1	1	CD
cord-023417-by18aczt	45	8	S.	S.	NNP
cord-023417-by18aczt	45	9	Adikari	Adikari	NNP
cord-023417-by18aczt	45	10	,	,	,
cord-023417-by18aczt	45	11	1	1	CD
cord-023417-by18aczt	45	12	U.	U.	NNP
cord-023417-by18aczt	45	13	Båve	Båve	NNP
cord-023417-by18aczt	45	14	,	,	,
cord-023417-by18aczt	45	15	2	2	CD
cord-023417-by18aczt	45	16	A.	a.	NN
cord-023417-by18aczt	45	17	Sanna	Sanna	NNP
cord-023417-by18aczt	45	18	1,3	1,3	CD
cord-023417-by18aczt	45	19	&	&	CC
cord-023417-by18aczt	45	20	G.	G.	NNP
cord-023417-by18aczt	45	21	Alm	Alm	NNP
cord-023417-by18aczt	45	22	4	4	CD
cord-023417-by18aczt	45	23	DC	DC	NNP
cord-023417-by18aczt	45	24	antigens	antigen	NNS
cord-023417-by18aczt	45	25	(	(	-LRB-
cord-023417-by18aczt	45	26	BDCA	BDCA	NNP
cord-023417-by18aczt	45	27	)	)	-RRB-
cord-023417-by18aczt	45	28	and	and	CC
cord-023417-by18aczt	45	29	investigate	investigate	VB
cord-023417-by18aczt	45	30	their	-PRON-	PRP$
cord-023417-by18aczt	45	31	ability	ability	NN
cord-023417-by18aczt	45	32	to	to	TO
cord-023417-by18aczt	45	33	produce	produce	VB
cord-023417-by18aczt	45	34	Type	type	NN
cord-023417-by18aczt	45	35	I	-PRON-	PRP
cord-023417-by18aczt	45	36	IFN	IFN	NNP
cord-023417-by18aczt	45	37	in	in	IN
cord-023417-by18aczt	45	38	response	response	NN
cord-023417-by18aczt	45	39	to	to	IN
cord-023417-by18aczt	45	40	virus	virus	NN
cord-023417-by18aczt	45	41	stimulation	stimulation	NN
cord-023417-by18aczt	45	42	.	.	.
cord-023417-by18aczt	46	1	We	-PRON-	PRP
cord-023417-by18aczt	46	2	show	show	VBP
cord-023417-by18aczt	46	3	that	that	IN
cord-023417-by18aczt	46	4	IFN	IFN	NNP
cord-023417-by18aczt	46	5	-	-	HYPH
cord-023417-by18aczt	46	6	b	b	NNP
cord-023417-by18aczt	46	7	induces	induce	VBZ
cord-023417-by18aczt	46	8	development	development	NN
cord-023417-by18aczt	46	9	of	of	IN
cord-023417-by18aczt	46	10	CD123	CD123	NNP
cord-023417-by18aczt	46	11	þ	þ	NNP
cord-023417-by18aczt	46	12	DC	DC	NNP
cord-023417-by18aczt	46	13	from	from	IN
cord-023417-by18aczt	46	14	human	human	JJ
cord-023417-by18aczt	46	15	blood	blood	NN
cord-023417-by18aczt	46	16	monocytes	monocyte	NNS
cord-023417-by18aczt	46	17	,	,	,
cord-023417-by18aczt	46	18	which	which	WDT
cord-023417-by18aczt	46	19	coexpress	coexpress	VBP
cord-023417-by18aczt	46	20	BDCA4	bdca4	CC
cord-023417-by18aczt	46	21	þ	þ	NNP
cord-023417-by18aczt	46	22	but	but	CC
cord-023417-by18aczt	46	23	are	be	VBP
cord-023417-by18aczt	46	24	negative	negative	JJ
cord-023417-by18aczt	46	25	for	for	IN
cord-023417-by18aczt	46	26	BDCA2	BDCA2	NNP
cord-023417-by18aczt	46	27	-	-	HYPH
cord-023417-by18aczt	46	28	,	,	,
cord-023417-by18aczt	46	29	a	a	DT
cord-023417-by18aczt	46	30	specific	specific	JJ
cord-023417-by18aczt	46	31	marker	marker	NN
cord-023417-by18aczt	46	32	for	for	IN
cord-023417-by18aczt	46	33	plasmacytoid	plasmacytoid	NNP
cord-023417-by18aczt	46	34	DC	DC	NNP
cord-023417-by18aczt	46	35	.	.	.
cord-023417-by18aczt	47	1	Such	such	JJ
cord-023417-by18aczt	47	2	IFN	IFN	NNP
cord-023417-by18aczt	47	3	-	-	HYPH
cord-023417-by18aczt	47	4	b	b	NNP
cord-023417-by18aczt	47	5	-	-	HYPH
cord-023417-by18aczt	47	6	modulated	modulate	VBN
cord-023417-by18aczt	47	7	DC	DC	NNP
cord-023417-by18aczt	47	8	produce	produce	VB
cord-023417-by18aczt	47	9	large	large	JJ
cord-023417-by18aczt	47	10	amounts	amount	NNS
cord-023417-by18aczt	47	11	of	of	IN
cord-023417-by18aczt	47	12	IL-6	IL-6	NNP
cord-023417-by18aczt	47	13	and	and	CC
cord-023417-by18aczt	47	14	IL-10	IL-10	NNP
cord-023417-by18aczt	47	15	,	,	,
cord-023417-by18aczt	47	16	but	but	CC
cord-023417-by18aczt	47	17	no	no	DT
cord-023417-by18aczt	47	18	IL-12p40	IL-12p40	NNP
cord-023417-by18aczt	47	19	and	and	CC
cord-023417-by18aczt	47	20	have	have	VBP
cord-023417-by18aczt	47	21	no	no	DT
cord-023417-by18aczt	47	22	enhanced	enhance	VBN
cord-023417-by18aczt	47	23	IFN	IFN	NNP
cord-023417-by18aczt	47	24	-	-	HYPH
cord-023417-by18aczt	47	25	b	b	NNP
cord-023417-by18aczt	47	26	and	and	CC
cord-023417-by18aczt	47	27	IFN	IFN	NNP
cord-023417-by18aczt	47	28	-	-	HYPH
cord-023417-by18aczt	47	29	b	b	NN
cord-023417-by18aczt	47	30	production	production	NN
cord-023417-by18aczt	47	31	.	.	.
cord-023417-by18aczt	48	1	The	the	DT
cord-023417-by18aczt	48	2	findings	finding	NNS
cord-023417-by18aczt	48	3	indicate	indicate	VBP
cord-023417-by18aczt	48	4	that	that	IN
cord-023417-by18aczt	48	5	IFN	IFN	NNP
cord-023417-by18aczt	48	6	-	-	HYPH
cord-023417-by18aczt	48	7	bmodulated	bmodulate	VBN
cord-023417-by18aczt	48	8	DC	DC	NNP
cord-023417-by18aczt	48	9	represent	represent	VBP
cord-023417-by18aczt	48	10	a	a	DT
cord-023417-by18aczt	48	11	myeloid	myeloid	JJ
cord-023417-by18aczt	48	12	DC	DC	NNP
cord-023417-by18aczt	48	13	subset	subset	VBN
cord-023417-by18aczt	48	14	with	with	IN
cord-023417-by18aczt	48	15	diminished	diminished	JJ
cord-023417-by18aczt	48	16	CD11c	CD11c	NNP
cord-023417-by18aczt	48	17	,	,	,
cord-023417-by18aczt	48	18	BDCA-1	BDCA-1	NNP
cord-023417-by18aczt	48	19	and	and	CC
cord-023417-by18aczt	48	20	CD1a	CD1a	NNP
cord-023417-by18aczt	48	21	expression	expression	NN
cord-023417-by18aczt	48	22	,	,	,
cord-023417-by18aczt	48	23	having	have	VBG
cord-023417-by18aczt	48	24	potent	potent	JJ
cord-023417-by18aczt	48	25	Th2-promoting	th2-promoting	CD
cord-023417-by18aczt	48	26	function	function	NN
cord-023417-by18aczt	48	27	but	but	CC
cord-023417-by18aczt	48	28	lacking	lack	VBG
cord-023417-by18aczt	48	29	antiviral	antiviral	JJ
cord-023417-by18aczt	48	30	capacity	capacity	NN
cord-023417-by18aczt	48	31	.	.	.
cord-023417-by18aczt	49	1	The	the	DT
cord-023417-by18aczt	49	2	association	association	NN
cord-023417-by18aczt	49	3	of	of	IN
cord-023417-by18aczt	49	4	psoriasis	psoriasis	NNP
cord-023417-by18aczt	49	5	with	with	IN
cord-023417-by18aczt	49	6	throat	throat	NN
cord-023417-by18aczt	49	7	infections	infection	NNS
cord-023417-by18aczt	49	8	by	by	IN
cord-023417-by18aczt	49	9	streptococcus	streptococcus	NN
cord-023417-by18aczt	49	10	pyogenes	pyogene	NNS
cord-023417-by18aczt	49	11	suggests	suggest	VBZ
cord-023417-by18aczt	49	12	a	a	DT
cord-023417-by18aczt	49	13	potential	potential	JJ
cord-023417-by18aczt	49	14	antigenic	antigenic	JJ
cord-023417-by18aczt	49	15	target	target	NN
cord-023417-by18aczt	49	16	for	for	IN
cord-023417-by18aczt	49	17	the	the	DT
cord-023417-by18aczt	49	18	T	t	NN
cord-023417-by18aczt	49	19	cells	cell	NNS
cord-023417-by18aczt	49	20	that	that	WDT
cord-023417-by18aczt	49	21	are	be	VBP
cord-023417-by18aczt	49	22	known	know	VBN
cord-023417-by18aczt	49	23	to	to	TO
cord-023417-by18aczt	49	24	infiltrate	infiltrate	VB
cord-023417-by18aczt	49	25	dermis	dermis	NN
cord-023417-by18aczt	49	26	and	and	CC
cord-023417-by18aczt	49	27	epidermis	epidermis	NN
cord-023417-by18aczt	49	28	of	of	IN
cord-023417-by18aczt	49	29	psoriatic	psoriatic	JJ
cord-023417-by18aczt	49	30	skin	skin	NN
cord-023417-by18aczt	49	31	.	.	.
cord-023417-by18aczt	50	1	Streptococcal	Streptococcal	NNP
cord-023417-by18aczt	50	2	M	M	NNP
cord-023417-by18aczt	50	3	protein	protein	NN
cord-023417-by18aczt	50	4	shares	share	VBZ
cord-023417-by18aczt	50	5	an	an	DT
cord-023417-by18aczt	50	6	extensive	extensive	JJ
cord-023417-by18aczt	50	7	sequence	sequence	NN
cord-023417-by18aczt	50	8	homology	homology	NN
cord-023417-by18aczt	50	9	with	with	IN
cord-023417-by18aczt	50	10	human	human	JJ
cord-023417-by18aczt	50	11	epidermal	epidermal	JJ
cord-023417-by18aczt	50	12	keratins	keratin	NNS
cord-023417-by18aczt	50	13	.	.	.
cord-023417-by18aczt	51	1	Keratins	keratin	NNS
cord-023417-by18aczt	51	2	16	16	CD
cord-023417-by18aczt	51	3	(	(	-LRB-
cord-023417-by18aczt	51	4	K16	K16	NNP
cord-023417-by18aczt	51	5	)	)	-RRB-
cord-023417-by18aczt	51	6	and	and	CC
cord-023417-by18aczt	51	7	17	17	CD
cord-023417-by18aczt	51	8	(	(	-LRB-
cord-023417-by18aczt	51	9	K17	K17	NNP
cord-023417-by18aczt	51	10	)	)	-RRB-
cord-023417-by18aczt	51	11	are	be	VBP
cord-023417-by18aczt	51	12	mostly	mostly	RB
cord-023417-by18aczt	51	13	absent	absent	JJ
cord-023417-by18aczt	51	14	from	from	IN
cord-023417-by18aczt	51	15	uninvolved	uninvolved	JJ
cord-023417-by18aczt	51	16	skin	skin	NN
cord-023417-by18aczt	51	17	but	but	CC
cord-023417-by18aczt	51	18	are	be	VBP
cord-023417-by18aczt	51	19	upregulated	upregulate	VBN
cord-023417-by18aczt	51	20	in	in	IN
cord-023417-by18aczt	51	21	psoriatic	psoriatic	JJ
cord-023417-by18aczt	51	22	lesions	lesion	NNS
cord-023417-by18aczt	51	23	.	.	.
cord-023417-by18aczt	52	1	There	there	EX
cord-023417-by18aczt	52	2	is	be	VBZ
cord-023417-by18aczt	52	3	increasing	increase	VBG
cord-023417-by18aczt	52	4	evidence	evidence	NN
cord-023417-by18aczt	52	5	that	that	IN
cord-023417-by18aczt	52	6	CD8	CD8	NNP
cord-023417-by18aczt	52	7	þ	þ	NNP
cord-023417-by18aczt	52	8	T	T	NNP
cord-023417-by18aczt	52	9	cells	cell	NNS
cord-023417-by18aczt	52	10	play	play	VBP
cord-023417-by18aczt	52	11	an	an	DT
cord-023417-by18aczt	52	12	important	important	JJ
cord-023417-by18aczt	52	13	effector	effector	NN
cord-023417-by18aczt	52	14	role	role	NN
cord-023417-by18aczt	52	15	in	in	IN
cord-023417-by18aczt	52	16	psoriasis	psoriasis	NN
cord-023417-by18aczt	52	17	and	and	CC
cord-023417-by18aczt	52	18	M	M	NNP
cord-023417-by18aczt	52	19	proteinprimed	proteinprimed	NNP
cord-023417-by18aczt	52	20	T	T	NNP
cord-023417-by18aczt	52	21	cells	cell	NNS
cord-023417-by18aczt	52	22	may	may	MD
cord-023417-by18aczt	52	23	recognize	recognize	VB
cord-023417-by18aczt	52	24	these	these	DT
cord-023417-by18aczt	52	25	shared	share	VBN
cord-023417-by18aczt	52	26	epitopes	epitope	NNS
cord-023417-by18aczt	52	27	in	in	IN
cord-023417-by18aczt	52	28	skin	skin	NN
cord-023417-by18aczt	52	29	via	via	IN
cord-023417-by18aczt	52	30	molecular	molecular	JJ
cord-023417-by18aczt	52	31	mimicry	mimicry	NN
cord-023417-by18aczt	52	32	.	.	.
cord-023417-by18aczt	53	1	To	to	TO
cord-023417-by18aczt	53	2	identify	identify	VB
cord-023417-by18aczt	53	3	candidate	candidate	NN
cord-023417-by18aczt	53	4	epitopes	epitope	NNS
cord-023417-by18aczt	53	5	,	,	,
cord-023417-by18aczt	53	6	peptides	peptide	NNS
cord-023417-by18aczt	53	7	with	with	IN
cord-023417-by18aczt	53	8	sequences	sequence	NNS
cord-023417-by18aczt	53	9	from	from	IN
cord-023417-by18aczt	53	10	K17	K17	NNP
cord-023417-by18aczt	53	11	were	be	VBD
cord-023417-by18aczt	53	12	selected	select	VBN
cord-023417-by18aczt	53	13	on	on	IN
cord-023417-by18aczt	53	14	the	the	DT
cord-023417-by18aczt	53	15	basis	basis	NN
cord-023417-by18aczt	53	16	of	of	IN
cord-023417-by18aczt	53	17	predicted	predict	VBN
cord-023417-by18aczt	53	18	binding	bind	VBG
cord-023417-by18aczt	53	19	to	to	IN
cord-023417-by18aczt	53	20	HLA	HLA	NNP
cord-023417-by18aczt	53	21	-	-	HYPH
cord-023417-by18aczt	53	22	Cw6	cw6	NN
cord-023417-by18aczt	53	23	and	and	CC
cord-023417-by18aczt	53	24	sequence	sequence	NN
cord-023417-by18aczt	53	25	similarities	similarity	NNS
cord-023417-by18aczt	53	26	with	with	IN
cord-023417-by18aczt	53	27	M6	m6	JJ
cord-023417-by18aczt	53	28	protein	protein	NN
cord-023417-by18aczt	53	29	.	.	.
cord-023417-by18aczt	54	1	Matched	match	VBN
cord-023417-by18aczt	54	2	peptides	peptide	NNS
cord-023417-by18aczt	54	3	from	from	IN
cord-023417-by18aczt	54	4	the	the	DT
cord-023417-by18aczt	54	5	sequence	sequence	NN
cord-023417-by18aczt	54	6	of	of	IN
cord-023417-by18aczt	54	7	M6	m6	JJ
cord-023417-by18aczt	54	8	protein	protein	NN
cord-023417-by18aczt	54	9	and	and	CC
cord-023417-by18aczt	54	10	a	a	DT
cord-023417-by18aczt	54	11	set	set	NN
cord-023417-by18aczt	54	12	of	of	IN
cord-023417-by18aczt	54	13	peptides	peptide	NNS
cord-023417-by18aczt	54	14	with	with	IN
cord-023417-by18aczt	54	15	poor	poor	JJ
cord-023417-by18aczt	54	16	predicted	predict	VBN
cord-023417-by18aczt	54	17	binding	binding	NN
cord-023417-by18aczt	54	18	were	be	VBD
cord-023417-by18aczt	54	19	also	also	RB
cord-023417-by18aczt	54	20	selected	select	VBN
cord-023417-by18aczt	54	21	.	.	.
cord-023417-by18aczt	55	1	Cw6	Cw6	NNP
cord-023417-by18aczt	55	2	þ	þ	NNP
cord-023417-by18aczt	55	3	individuals	individual	NNS
cord-023417-by18aczt	55	4	with	with	IN
cord-023417-by18aczt	55	5	psoriasis	psoriasis	NN
cord-023417-by18aczt	55	6	and	and	CC
cord-023417-by18aczt	55	7	Cw6	cw6	VBP
cord-023417-by18aczt	55	8	þ	þ	NNP
cord-023417-by18aczt	55	9	healthy	healthy	JJ
cord-023417-by18aczt	55	10	controls	control	NNS
cord-023417-by18aczt	55	11	,	,	,
cord-023417-by18aczt	55	12	having	have	VBG
cord-023417-by18aczt	55	13	a	a	DT
cord-023417-by18aczt	55	14	family	family	NN
cord-023417-by18aczt	55	15	history	history	NN
cord-023417-by18aczt	55	16	of	of	IN
cord-023417-by18aczt	55	17	psoriasis	psoriasis	NN
cord-023417-by18aczt	55	18	,	,	,
cord-023417-by18aczt	55	19	were	be	VBD
cord-023417-by18aczt	55	20	recruited	recruit	VBN
cord-023417-by18aczt	55	21	.	.	.
cord-023417-by18aczt	56	1	PBMCs	pbmc	NNS
cord-023417-by18aczt	56	2	were	be	VBD
cord-023417-by18aczt	56	3	incubated	incubate	VBN
cord-023417-by18aczt	56	4	with	with	IN
cord-023417-by18aczt	56	5	the	the	DT
cord-023417-by18aczt	56	6	peptide	peptide	NN
cord-023417-by18aczt	56	7	antigens	antigen	NNS
cord-023417-by18aczt	56	8	.	.	.
cord-023417-by18aczt	57	1	T	t	NN
cord-023417-by18aczt	57	2	-	-	HYPH
cord-023417-by18aczt	57	3	cell	cell	NN
cord-023417-by18aczt	57	4	activation	activation	NN
cord-023417-by18aczt	57	5	in	in	IN
cord-023417-by18aczt	57	6	the	the	DT
cord-023417-by18aczt	57	7	CD4	CD4	NNP
cord-023417-by18aczt	57	8	þ	þ	NNP
cord-023417-by18aczt	57	9	,	,	,
cord-023417-by18aczt	57	10	CD8	CD8	NNP
cord-023417-by18aczt	57	11	þ	þ	NNP
cord-023417-by18aczt	57	12	and	and	CC
cord-023417-by18aczt	57	13	later	later	RBR
cord-023417-by18aczt	57	14	the	the	DT
cord-023417-by18aczt	57	15	skin	skin	NN
cord-023417-by18aczt	57	16	-	-	HYPH
cord-023417-by18aczt	57	17	homing	home	VBG
cord-023417-by18aczt	57	18	cutaneous	cutaneous	JJ
cord-023417-by18aczt	57	19	lymphocyteassociated	lymphocyteassociated	JJ
cord-023417-by18aczt	57	20	antigen	antigen	NN
cord-023417-by18aczt	57	21	(	(	-LRB-
cord-023417-by18aczt	57	22	CLA)-expressing	cla)-expresse	VBG
cord-023417-by18aczt	57	23	subset	subset	NN
cord-023417-by18aczt	57	24	of	of	IN
cord-023417-by18aczt	57	25	CD8	CD8	NNP
cord-023417-by18aczt	57	26	þ	þ	NNP
cord-023417-by18aczt	57	27	T	T	NNP
cord-023417-by18aczt	57	28	cells	cell	NNS
cord-023417-by18aczt	57	29	was	be	VBD
cord-023417-by18aczt	57	30	evaluated	evaluate	VBN
cord-023417-by18aczt	57	31	by	by	IN
cord-023417-by18aczt	57	32	CD69	CD69	NNP
cord-023417-by18aczt	57	33	expression	expression	NN
cord-023417-by18aczt	57	34	and	and	CC
cord-023417-by18aczt	57	35	intracellular	intracellular	JJ
cord-023417-by18aczt	57	36	IFN	IFN	NNP
cord-023417-by18aczt	57	37	-	-	HYPH
cord-023417-by18aczt	57	38	g	g	NN
cord-023417-by18aczt	57	39	accumulation	accumulation	NN
cord-023417-by18aczt	57	40	using	use	VBG
cord-023417-by18aczt	57	41	flow	flow	NN
cord-023417-by18aczt	57	42	cytometry	cytometry	NN
cord-023417-by18aczt	57	43	.	.	.
cord-023417-by18aczt	58	1	We	-PRON-	PRP
cord-023417-by18aczt	58	2	demonstrate	demonstrate	VBP
cord-023417-by18aczt	58	3	that	that	IN
cord-023417-by18aczt	58	4	Cw6	cw6	NN
cord-023417-by18aczt	58	5	þ	þ	CD
cord-023417-by18aczt	58	6	psoriasis	psoriasis	NN
cord-023417-by18aczt	58	7	patients	patient	NNS
cord-023417-by18aczt	58	8	had	have	VBD
cord-023417-by18aczt	58	9	significant	significant	JJ
cord-023417-by18aczt	58	10	CD8	CD8	NNP
cord-023417-by18aczt	58	11	þ	þ	NNP
cord-023417-by18aczt	58	12	T	T	NNP
cord-023417-by18aczt	58	13	-	-	HYPH
cord-023417-by18aczt	58	14	cell	cell	NN
cord-023417-by18aczt	58	15	IFN	IFN	NNP
cord-023417-by18aczt	58	16	-	-	HYPH
cord-023417-by18aczt	58	17	g	g	NNP
cord-023417-by18aczt	58	18	responses	response	NNS
cord-023417-by18aczt	58	19	to	to	IN
cord-023417-by18aczt	58	20	peptides	peptide	NNS
cord-023417-by18aczt	58	21	from	from	IN
cord-023417-by18aczt	58	22	K17	K17	NNP
cord-023417-by18aczt	58	23	and	and	CC
cord-023417-by18aczt	58	24	M6	M6	NNP
cord-023417-by18aczt	58	25	protein	protein	NN
cord-023417-by18aczt	58	26	selected	select	VBN
cord-023417-by18aczt	58	27	on	on	IN
cord-023417-by18aczt	58	28	the	the	DT
cord-023417-by18aczt	58	29	basis	basis	NN
cord-023417-by18aczt	58	30	of	of	IN
cord-023417-by18aczt	58	31	sequence	sequence	NN
cord-023417-by18aczt	58	32	homology	homology	NN
cord-023417-by18aczt	58	33	and	and	CC
cord-023417-by18aczt	58	34	predicted	predict	VBD
cord-023417-by18aczt	58	35	HLA	HLA	NNP
cord-023417-by18aczt	58	36	-	-	HYPH
cord-023417-by18aczt	58	37	Cw*0602	cw*0602	NN
cord-023417-by18aczt	58	38	binding	binding	NN
cord-023417-by18aczt	58	39	.	.	.
cord-023417-by18aczt	59	1	These	these	DT
cord-023417-by18aczt	59	2	responses	response	NNS
cord-023417-by18aczt	59	3	were	be	VBD
cord-023417-by18aczt	59	4	about	about	RB
cord-023417-by18aczt	59	5	10	10	CD
cord-023417-by18aczt	59	6	times	time	NNS
cord-023417-by18aczt	59	7	more	more	RBR
cord-023417-by18aczt	59	8	frequent	frequent	JJ
cord-023417-by18aczt	59	9	in	in	IN
cord-023417-by18aczt	59	10	the	the	DT
cord-023417-by18aczt	59	11	skin	skin	NN
cord-023417-by18aczt	59	12	-	-	HYPH
cord-023417-by18aczt	59	13	homing	home	VBG
cord-023417-by18aczt	59	14	cutaneous	cutaneous	JJ
cord-023417-by18aczt	59	15	lymphocyte	lymphocyte	NN
cord-023417-by18aczt	59	16	-	-	HYPH
cord-023417-by18aczt	59	17	associated	associate	VBN
cord-023417-by18aczt	59	18	antigen	antigen	NN
cord-023417-by18aczt	59	19	-	-	HYPH
cord-023417-by18aczt	59	20	expressing	express	VBG
cord-023417-by18aczt	60	1	(	(	-LRB-
cord-023417-by18aczt	60	2	CLA	CLA	NNP
cord-023417-by18aczt	60	3	þ	þ	NNP
cord-023417-by18aczt	60	4	)	)	-RRB-
cord-023417-by18aczt	61	1	subset	subset	VBN
cord-023417-by18aczt	61	2	of	of	IN
cord-023417-by18aczt	61	3	CD8	CD8	NNP
cord-023417-by18aczt	61	4	þ	þ	NNP
cord-023417-by18aczt	61	5	T	T	NNP
cord-023417-by18aczt	61	6	cells	cell	NNS
cord-023417-by18aczt	61	7	.	.	.
cord-023417-by18aczt	62	1	CD4	CD4	NNP
cord-023417-by18aczt	62	2	þ	þ	NNP
cord-023417-by18aczt	62	3	T	t	NN
cord-023417-by18aczt	62	4	cells	cell	NNS
cord-023417-by18aczt	62	5	showed	show	VBD
cord-023417-by18aczt	62	6	only	only	RB
cord-023417-by18aczt	62	7	borderline	borderline	JJ
cord-023417-by18aczt	62	8	responses	response	NNS
cord-023417-by18aczt	62	9	.	.	.
cord-023417-by18aczt	63	1	CD8	CD8	NNP
cord-023417-by18aczt	63	2	þ	þ	NNP
cord-023417-by18aczt	63	3	T	T	NNP
cord-023417-by18aczt	63	4	cells	cell	NNS
cord-023417-by18aczt	63	5	from	from	IN
cord-023417-by18aczt	63	6	Cw6	cw6	NN
cord-023417-by18aczt	63	7	þ	þ	NNP
cord-023417-by18aczt	63	8	nonpsoriatic	nonpsoriatic	JJ
cord-023417-by18aczt	63	9	individuals	individual	NNS
cord-023417-by18aczt	63	10	responded	respond	VBD
cord-023417-by18aczt	63	11	to	to	IN
cord-023417-by18aczt	63	12	some	some	DT
cord-023417-by18aczt	63	13	M6	m6	JJ
cord-023417-by18aczt	63	14	peptides	peptide	NNS
cord-023417-by18aczt	63	15	but	but	CC
cord-023417-by18aczt	63	16	very	very	RB
cord-023417-by18aczt	63	17	rarely	rarely	RB
cord-023417-by18aczt	63	18	to	to	IN
cord-023417-by18aczt	63	19	K17	K17	NNP
cord-023417-by18aczt	63	20	peptides	peptide	NNS
cord-023417-by18aczt	63	21	,	,	,
cord-023417-by18aczt	63	22	and	and	CC
cord-023417-by18aczt	63	23	this	this	DT
cord-023417-by18aczt	63	24	also	also	RB
cord-023417-by18aczt	63	25	applied	apply	VBD
cord-023417-by18aczt	63	26	to	to	IN
cord-023417-by18aczt	63	27	the	the	DT
cord-023417-by18aczt	63	28	CLA	CLA	NNP
cord-023417-by18aczt	63	29	þ	þ	NNP
cord-023417-by18aczt	63	30	CD8	CD8	NNP
cord-023417-by18aczt	63	31	þ	þ	NNP
cord-023417-by18aczt	63	32	subset	subset	JJ
cord-023417-by18aczt	63	33	.	.	.
cord-023417-by18aczt	64	1	These	these	DT
cord-023417-by18aczt	64	2	findings	finding	NNS
cord-023417-by18aczt	64	3	indicate	indicate	VBP
cord-023417-by18aczt	64	4	that	that	IN
cord-023417-by18aczt	64	5	psoriatic	psoriatic	JJ
cord-023417-by18aczt	64	6	individuals	individual	NNS
cord-023417-by18aczt	64	7	have	have	VBP
cord-023417-by18aczt	64	8	CD8	CD8	NNP
cord-023417-by18aczt	64	9	þ	þ	NNP
cord-023417-by18aczt	64	10	T	T	NNP
cord-023417-by18aczt	64	11	cells	cell	NNS
cord-023417-by18aczt	64	12	that	that	WDT
cord-023417-by18aczt	64	13	recognize	recognize	VBP
cord-023417-by18aczt	64	14	keratin	keratin	NN
cord-023417-by18aczt	64	15	self	self	NN
cord-023417-by18aczt	64	16	-	-	HYPH
cord-023417-by18aczt	64	17	antigens	antigen	NNS
cord-023417-by18aczt	64	18	and	and	CC
cord-023417-by18aczt	64	19	that	that	IN
cord-023417-by18aczt	64	20	epitopes	epitope	NNS
cord-023417-by18aczt	64	21	shared	share	VBN
cord-023417-by18aczt	64	22	by	by	IN
cord-023417-by18aczt	64	23	streptococcal	streptococcal	JJ
cord-023417-by18aczt	64	24	M	M	NNP
cord-023417-by18aczt	64	25	protein	protein	NN
cord-023417-by18aczt	64	26	and	and	CC
cord-023417-by18aczt	64	27	human	human	JJ
cord-023417-by18aczt	64	28	keratin	keratin	NN
cord-023417-by18aczt	64	29	may	may	MD
cord-023417-by18aczt	64	30	be	be	VB
cord-023417-by18aczt	64	31	targets	target	NNS
cord-023417-by18aczt	64	32	for	for	IN
cord-023417-by18aczt	64	33	the	the	DT
cord-023417-by18aczt	64	34	CD8	CD8	NNP
cord-023417-by18aczt	64	35	þ	þ	NNP
cord-023417-by18aczt	64	36	T	T	NNP
cord-023417-by18aczt	64	37	cells	cell	NNS
cord-023417-by18aczt	64	38	that	that	WDT
cord-023417-by18aczt	64	39	infiltrate	infiltrate	VBP
cord-023417-by18aczt	64	40	psoriatic	psoriatic	JJ
cord-023417-by18aczt	64	41	skin	skin	NN
cord-023417-by18aczt	64	42	lesions	lesion	NNS
cord-023417-by18aczt	64	43	.	.	.
cord-023417-by18aczt	65	1	Autoantibodies	Autoantibodies	NNP
cord-023417-by18aczt	65	2	directed	direct	VBN
cord-023417-by18aczt	65	3	against	against	IN
cord-023417-by18aczt	65	4	citrulline	citrulline	NN
cord-023417-by18aczt	65	5	-	-	HYPH
cord-023417-by18aczt	65	6	containing	contain	VBG
cord-023417-by18aczt	65	7	proteins	protein	NNS
cord-023417-by18aczt	65	8	have	have	VBP
cord-023417-by18aczt	65	9	an	an	DT
cord-023417-by18aczt	65	10	impressive	impressive	JJ
cord-023417-by18aczt	65	11	specificity	specificity	NN
cord-023417-by18aczt	65	12	of	of	IN
cord-023417-by18aczt	65	13	nearly	nearly	RB
cord-023417-by18aczt	65	14	100	100	CD
cord-023417-by18aczt	65	15	%	%	NN
cord-023417-by18aczt	65	16	in	in	IN
cord-023417-by18aczt	65	17	RA	RA	NNP
cord-023417-by18aczt	65	18	patients	patient	NNS
cord-023417-by18aczt	65	19	and	and	CC
cord-023417-by18aczt	65	20	a	a	DT
cord-023417-by18aczt	65	21	suggestive	suggestive	JJ
cord-023417-by18aczt	65	22	involvement	involvement	NN
cord-023417-by18aczt	65	23	in	in	IN
cord-023417-by18aczt	65	24	the	the	DT
cord-023417-by18aczt	65	25	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	65	26	.	.	.
cord-023417-by18aczt	66	1	The	the	DT
cord-023417-by18aczt	66	2	targeted	target	VBN
cord-023417-by18aczt	66	3	epitopes	epitope	NNS
cord-023417-by18aczt	66	4	are	be	VBP
cord-023417-by18aczt	66	5	generated	generate	VBN
cord-023417-by18aczt	66	6	by	by	IN
cord-023417-by18aczt	66	7	a	a	DT
cord-023417-by18aczt	66	8	post	post	JJ
cord-023417-by18aczt	66	9	-	-	JJ
cord-023417-by18aczt	66	10	translational	translational	JJ
cord-023417-by18aczt	66	11	modification	modification	NN
cord-023417-by18aczt	66	12	catalysed	catalyse	VBN
cord-023417-by18aczt	66	13	by	by	IN
cord-023417-by18aczt	67	1	the	the	DT
cord-023417-by18aczt	67	2	calcium	calcium	NN
cord-023417-by18aczt	67	3	-	-	HYPH
cord-023417-by18aczt	67	4	dependent	dependent	JJ
cord-023417-by18aczt	67	5	enzyme	enzyme	NN
cord-023417-by18aczt	67	6	peptidyl	peptidyl	NNP
cord-023417-by18aczt	67	7	arginine	arginine	NN
cord-023417-by18aczt	67	8	deaminase	deaminase	NNP
cord-023417-by18aczt	67	9	that	that	WDT
cord-023417-by18aczt	67	10	converts	convert	VBZ
cord-023417-by18aczt	67	11	the	the	DT
cord-023417-by18aczt	67	12	positively	positively	RB
cord-023417-by18aczt	67	13	charged	charge	VBN
cord-023417-by18aczt	67	14	arginine	arginine	NN
cord-023417-by18aczt	67	15	to	to	IN
cord-023417-by18aczt	67	16	polar	polar	JJ
cord-023417-by18aczt	67	17	but	but	CC
cord-023417-by18aczt	67	18	uncharged	uncharged	JJ
cord-023417-by18aczt	67	19	citrullin	citrullin	NNP
cord-023417-by18aczt	67	20	.	.	.
cord-023417-by18aczt	68	1	The	the	DT
cord-023417-by18aczt	68	2	aim	aim	NN
cord-023417-by18aczt	68	3	of	of	IN
cord-023417-by18aczt	68	4	this	this	DT
cord-023417-by18aczt	68	5	study	study	NN
cord-023417-by18aczt	68	6	was	be	VBD
cord-023417-by18aczt	68	7	to	to	TO
cord-023417-by18aczt	68	8	analyse	analyse	VB
cord-023417-by18aczt	68	9	the	the	DT
cord-023417-by18aczt	68	10	presence	presence	NN
cord-023417-by18aczt	68	11	of	of	IN
cord-023417-by18aczt	68	12	citrulline	citrulline	NN
cord-023417-by18aczt	68	13	in	in	IN
cord-023417-by18aczt	68	14	the	the	DT
cord-023417-by18aczt	68	15	joints	joint	NNS
cord-023417-by18aczt	68	16	at	at	IN
cord-023417-by18aczt	68	17	different	different	JJ
cord-023417-by18aczt	68	18	time	time	NN
cord-023417-by18aczt	68	19	points	point	NNS
cord-023417-by18aczt	68	20	of	of	IN
cord-023417-by18aczt	68	21	collagen	collagen	NN
cord-023417-by18aczt	68	22	-	-	HYPH
cord-023417-by18aczt	68	23	induced	induce	VBN
cord-023417-by18aczt	68	24	arthritis	arthritis	NN
cord-023417-by18aczt	68	25	in	in	IN
cord-023417-by18aczt	68	26	DA	DA	NNP
cord-023417-by18aczt	68	27	rats	rat	NNS
cord-023417-by18aczt	68	28	by	by	IN
cord-023417-by18aczt	68	29	immunohistochemistry	immunohistochemistry	NN
cord-023417-by18aczt	68	30	and	and	CC
cord-023417-by18aczt	68	31	to	to	TO
cord-023417-by18aczt	68	32	investigate	investigate	VB
cord-023417-by18aczt	68	33	how	how	WRB
cord-023417-by18aczt	68	34	immunogenicity	immunogenicity	NN
cord-023417-by18aczt	68	35	and	and	CC
cord-023417-by18aczt	68	36	arthritogenicity	arthritogenicity	NN
cord-023417-by18aczt	68	37	was	be	VBD
cord-023417-by18aczt	68	38	affected	affect	VBN
cord-023417-by18aczt	68	39	by	by	IN
cord-023417-by18aczt	68	40	citrullination	citrullination	NN
cord-023417-by18aczt	68	41	of	of	IN
cord-023417-by18aczt	68	42	rat	rat	NN
cord-023417-by18aczt	68	43	serum	serum	NN
cord-023417-by18aczt	68	44	albumin	albumin	NN
cord-023417-by18aczt	68	45	(	(	-LRB-
cord-023417-by18aczt	68	46	RSA	RSA	NNP
cord-023417-by18aczt	68	47	)	)	-RRB-
cord-023417-by18aczt	68	48	and	and	CC
cord-023417-by18aczt	68	49	collagen	collagen	NN
cord-023417-by18aczt	68	50	type	type	NN
cord-023417-by18aczt	68	51	II	II	NNP
cord-023417-by18aczt	68	52	(	(	-LRB-
cord-023417-by18aczt	68	53	CII	CII	NNP
cord-023417-by18aczt	68	54	)	)	-RRB-
cord-023417-by18aczt	68	55	.	.	.
cord-023417-by18aczt	69	1	Our	-PRON-	PRP$
cord-023417-by18aczt	69	2	results	result	NNS
cord-023417-by18aczt	69	3	indicate	indicate	VBP
cord-023417-by18aczt	69	4	that	that	IN
cord-023417-by18aczt	69	5	citrulline	citrulline	NN
cord-023417-by18aczt	69	6	could	could	MD
cord-023417-by18aczt	69	7	be	be	VB
cord-023417-by18aczt	69	8	detected	detect	VBN
cord-023417-by18aczt	69	9	in	in	IN
cord-023417-by18aczt	69	10	joints	joint	NNS
cord-023417-by18aczt	69	11	of	of	IN
cord-023417-by18aczt	69	12	arthritic	arthritic	JJ
cord-023417-by18aczt	69	13	animals	animal	NNS
cord-023417-by18aczt	69	14	,	,	,
cord-023417-by18aczt	69	15	first	first	JJ
cord-023417-by18aczt	69	16	appearance	appearance	NN
cord-023417-by18aczt	69	17	at	at	IN
cord-023417-by18aczt	69	18	the	the	DT
cord-023417-by18aczt	69	19	onset	onset	NN
cord-023417-by18aczt	69	20	of	of	IN
cord-023417-by18aczt	69	21	disease	disease	NN
cord-023417-by18aczt	69	22	and	and	CC
cord-023417-by18aczt	69	23	increasing	increase	VBG
cord-023417-by18aczt	69	24	as	as	IN
cord-023417-by18aczt	69	25	disease	disease	NN
cord-023417-by18aczt	69	26	progressed	progress	VBD
cord-023417-by18aczt	69	27	into	into	IN
cord-023417-by18aczt	69	28	a	a	DT
cord-023417-by18aczt	69	29	chronic	chronic	JJ
cord-023417-by18aczt	69	30	state	state	NN
cord-023417-by18aczt	69	31	.	.	.
cord-023417-by18aczt	70	1	Unimmunized	unimmunized	JJ
cord-023417-by18aczt	70	2	animals	animal	NNS
cord-023417-by18aczt	70	3	or	or	CC
cord-023417-by18aczt	70	4	time	time	NN
cord-023417-by18aczt	70	5	points	point	NNS
cord-023417-by18aczt	70	6	before	before	IN
cord-023417-by18aczt	70	7	clinical	clinical	JJ
cord-023417-by18aczt	70	8	signs	sign	NNS
cord-023417-by18aczt	70	9	of	of	IN
cord-023417-by18aczt	70	10	arthritis	arthritis	NN
cord-023417-by18aczt	70	11	were	be	VBD
cord-023417-by18aczt	70	12	negative	negative	JJ
cord-023417-by18aczt	70	13	.	.	.
cord-023417-by18aczt	71	1	By	by	IN
cord-023417-by18aczt	71	2	morphology	morphology	NN
cord-023417-by18aczt	71	3	,	,	,
cord-023417-by18aczt	71	4	we	-PRON-	PRP
cord-023417-by18aczt	71	5	state	state	VBP
cord-023417-by18aczt	71	6	that	that	IN
cord-023417-by18aczt	71	7	some	some	DT
cord-023417-by18aczt	71	8	infiltrating	infiltrate	VBG
cord-023417-by18aczt	71	9	macrophages	macrophage	NNS
cord-023417-by18aczt	71	10	as	as	RB
cord-023417-by18aczt	71	11	well	well	RB
cord-023417-by18aczt	71	12	as	as	IN
cord-023417-by18aczt	71	13	the	the	DT
cord-023417-by18aczt	71	14	cartilage	cartilage	NN
cord-023417-by18aczt	71	15	surface	surface	NN
cord-023417-by18aczt	71	16	stain	stain	NN
cord-023417-by18aczt	71	17	positive	positive	JJ
cord-023417-by18aczt	71	18	for	for	IN
cord-023417-by18aczt	71	19	citrulline	citrulline	NN
cord-023417-by18aczt	71	20	,	,	,
cord-023417-by18aczt	71	21	while	while	IN
cord-023417-by18aczt	71	22	the	the	DT
cord-023417-by18aczt	71	23	major	major	JJ
cord-023417-by18aczt	71	24	source	source	NN
cord-023417-by18aczt	71	25	of	of	IN
cord-023417-by18aczt	71	26	citrullinated	citrullinate	VBN
cord-023417-by18aczt	71	27	proteins	protein	NNS
cord-023417-by18aczt	71	28	appears	appear	VBZ
cord-023417-by18aczt	71	29	to	to	TO
cord-023417-by18aczt	71	30	be	be	VB
cord-023417-by18aczt	71	31	fibrin	fibrin	NN
cord-023417-by18aczt	71	32	depositions	deposition	NNS
cord-023417-by18aczt	71	33	.	.	.
cord-023417-by18aczt	72	1	A	a	DT
cord-023417-by18aczt	72	2	specific	specific	JJ
cord-023417-by18aczt	72	3	Cit	Cit	NNP
cord-023417-by18aczt	72	4	-	-	HYPH
cord-023417-by18aczt	72	5	RSA	RSA	NNP
cord-023417-by18aczt	72	6	T	t	NN
cord-023417-by18aczt	72	7	-	-	HYPH
cord-023417-by18aczt	72	8	cell	cell	NN
cord-023417-by18aczt	72	9	response	response	NN
cord-023417-by18aczt	72	10	was	be	VBD
cord-023417-by18aczt	72	11	observed	observe	VBN
cord-023417-by18aczt	72	12	in	in	IN
cord-023417-by18aczt	72	13	animals	animal	NNS
cord-023417-by18aczt	72	14	challenged	challenge	VBN
cord-023417-by18aczt	72	15	by	by	IN
cord-023417-by18aczt	72	16	citrullinated	citrullinate	VBN
cord-023417-by18aczt	72	17	RSA	RSA	NNP
cord-023417-by18aczt	72	18	,	,	,
cord-023417-by18aczt	72	19	no	no	DT
cord-023417-by18aczt	72	20	response	response	NN
cord-023417-by18aczt	72	21	was	be	VBD
cord-023417-by18aczt	72	22	recorded	record	VBN
cord-023417-by18aczt	72	23	when	when	WRB
cord-023417-by18aczt	72	24	RSA	RSA	NNP
cord-023417-by18aczt	72	25	was	be	VBD
cord-023417-by18aczt	72	26	used	use	VBN
cord-023417-by18aczt	72	27	as	as	IN
cord-023417-by18aczt	72	28	a	a	DT
cord-023417-by18aczt	72	29	stimulus	stimulus	NN
cord-023417-by18aczt	72	30	.	.	.
cord-023417-by18aczt	73	1	The	the	DT
cord-023417-by18aczt	73	2	IgG	igg	NN
cord-023417-by18aczt	73	3	analysis	analysis	NN
cord-023417-by18aczt	73	4	reveals	reveal	VBZ
cord-023417-by18aczt	73	5	not	not	RB
cord-023417-by18aczt	73	6	only	only	RB
cord-023417-by18aczt	73	7	a	a	DT
cord-023417-by18aczt	73	8	response	response	NN
cord-023417-by18aczt	73	9	towards	towards	IN
cord-023417-by18aczt	73	10	the	the	DT
cord-023417-by18aczt	73	11	modified	modify	VBN
cord-023417-by18aczt	73	12	protein	protein	NN
cord-023417-by18aczt	73	13	but	but	CC
cord-023417-by18aczt	73	14	also	also	RB
cord-023417-by18aczt	73	15	cross	cross	NN
cord-023417-by18aczt	73	16	-	-	NN
cord-023417-by18aczt	73	17	reactivity	reactivity	NN
cord-023417-by18aczt	73	18	to	to	IN
cord-023417-by18aczt	73	19	native	native	JJ
cord-023417-by18aczt	73	20	RSA	RSA	NNP
cord-023417-by18aczt	73	21	.	.	.
cord-023417-by18aczt	74	1	No	no	DT
cord-023417-by18aczt	74	2	T	t	NN
cord-023417-by18aczt	74	3	-	-	HYPH
cord-023417-by18aczt	74	4	cell	cell	NN
cord-023417-by18aczt	74	5	or	or	CC
cord-023417-by18aczt	74	6	B	b	NN
cord-023417-by18aczt	74	7	-	-	HYPH
cord-023417-by18aczt	74	8	cell	cell	NN
cord-023417-by18aczt	74	9	response	response	NN
cord-023417-by18aczt	74	10	was	be	VBD
cord-023417-by18aczt	74	11	noted	note	VBN
cord-023417-by18aczt	74	12	in	in	IN
cord-023417-by18aczt	74	13	animals	animal	NNS
cord-023417-by18aczt	74	14	injected	inject	VBN
cord-023417-by18aczt	74	15	with	with	IN
cord-023417-by18aczt	74	16	unmodified	unmodified	JJ
cord-023417-by18aczt	74	17	RSA	rsa	NN
cord-023417-by18aczt	74	18	.	.	.
cord-023417-by18aczt	75	1	Cit	Cit	NNP
cord-023417-by18aczt	75	2	-	-	HYPH
cord-023417-by18aczt	75	3	CII	CII	NNP
cord-023417-by18aczt	75	4	induced	induce	VBD
cord-023417-by18aczt	75	5	a	a	DT
cord-023417-by18aczt	75	6	disease	disease	NN
cord-023417-by18aczt	75	7	with	with	IN
cord-023417-by18aczt	75	8	higher	high	JJR
cord-023417-by18aczt	75	9	incidence	incidence	NN
cord-023417-by18aczt	75	10	and	and	CC
cord-023417-by18aczt	75	11	earlier	early	JJR
cord-023417-by18aczt	75	12	onset	onset	NN
cord-023417-by18aczt	75	13	than	than	IN
cord-023417-by18aczt	75	14	did	do	VBD
cord-023417-by18aczt	75	15	the	the	DT
cord-023417-by18aczt	75	16	native	native	JJ
cord-023417-by18aczt	75	17	counterpart	counterpart	NN
cord-023417-by18aczt	75	18	.	.	.
cord-023417-by18aczt	76	1	We	-PRON-	PRP
cord-023417-by18aczt	76	2	conclude	conclude	VBP
cord-023417-by18aczt	76	3	that	that	IN
cord-023417-by18aczt	76	4	,	,	,
cord-023417-by18aczt	76	5	in	in	IN
cord-023417-by18aczt	76	6	contrast	contrast	NN
cord-023417-by18aczt	76	7	to	to	IN
cord-023417-by18aczt	76	8	the	the	DT
cord-023417-by18aczt	76	9	human	human	JJ
cord-023417-by18aczt	76	10	disease	disease	NN
cord-023417-by18aczt	76	11	,	,	,
cord-023417-by18aczt	76	12	citrulline	citrulline	NN
cord-023417-by18aczt	76	13	does	do	VBZ
cord-023417-by18aczt	76	14	not	not	RB
cord-023417-by18aczt	76	15	seem	seem	VB
cord-023417-by18aczt	76	16	to	to	TO
cord-023417-by18aczt	76	17	appear	appear	VB
cord-023417-by18aczt	76	18	before	before	IN
cord-023417-by18aczt	76	19	clinical	clinical	JJ
cord-023417-by18aczt	76	20	signs	sign	NNS
cord-023417-by18aczt	76	21	.	.	.
cord-023417-by18aczt	77	1	As	as	IN
cord-023417-by18aczt	77	2	inflammation	inflammation	NN
cord-023417-by18aczt	77	3	proceeds	proceed	NNS
cord-023417-by18aczt	77	4	,	,	,
cord-023417-by18aczt	77	5	citrulline	citrulline	NN
cord-023417-by18aczt	77	6	is	be	VBZ
cord-023417-by18aczt	77	7	detected	detect	VBN
cord-023417-by18aczt	77	8	specifically	specifically	RB
cord-023417-by18aczt	77	9	in	in	IN
cord-023417-by18aczt	77	10	the	the	DT
cord-023417-by18aczt	77	11	joints	joint	NNS
cord-023417-by18aczt	77	12	.	.	.
cord-023417-by18aczt	78	1	All	all	DT
cord-023417-by18aczt	78	2	other	other	JJ
cord-023417-by18aczt	78	3	organs	organ	NNS
cord-023417-by18aczt	78	4	investigated	investigate	VBN
cord-023417-by18aczt	78	5	were	be	VBD
cord-023417-by18aczt	78	6	negative	negative	JJ
cord-023417-by18aczt	78	7	.	.	.
cord-023417-by18aczt	79	1	We	-PRON-	PRP
cord-023417-by18aczt	79	2	also	also	RB
cord-023417-by18aczt	79	3	conclude	conclude	VBP
cord-023417-by18aczt	79	4	that	that	IN
cord-023417-by18aczt	79	5	citrullination	citrullination	NN
cord-023417-by18aczt	79	6	of	of	IN
cord-023417-by18aczt	79	7	a	a	DT
cord-023417-by18aczt	79	8	protein	protein	NN
cord-023417-by18aczt	79	9	can	can	MD
cord-023417-by18aczt	79	10	break	break	VB
cord-023417-by18aczt	79	11	tolerance	tolerance	NN
cord-023417-by18aczt	79	12	and	and	CC
cord-023417-by18aczt	79	13	increase	increase	VB
cord-023417-by18aczt	79	14	its	-PRON-	PRP$
cord-023417-by18aczt	79	15	arthritogenic	arthritogenic	JJ
cord-023417-by18aczt	79	16	properties	property	NNS
cord-023417-by18aczt	79	17	.	.	.
cord-023417-by18aczt	80	1	Ectopic	ectopic	JJ
cord-023417-by18aczt	80	2	germinal	germinal	JJ
cord-023417-by18aczt	80	3	centers	center	NNS
cord-023417-by18aczt	80	4	(	(	-LRB-
cord-023417-by18aczt	80	5	GCs	GCs	NNP
cord-023417-by18aczt	80	6	)	)	-RRB-
cord-023417-by18aczt	80	7	can	can	MD
cord-023417-by18aczt	80	8	be	be	VB
cord-023417-by18aczt	80	9	detected	detect	VBN
cord-023417-by18aczt	80	10	in	in	IN
cord-023417-by18aczt	80	11	the	the	DT
cord-023417-by18aczt	80	12	salivary	salivary	JJ
cord-023417-by18aczt	80	13	glands	gland	NNS
cord-023417-by18aczt	80	14	of	of	IN
cord-023417-by18aczt	80	15	approximately	approximately	RB
cord-023417-by18aczt	80	16	1/5	1/5	CD
cord-023417-by18aczt	80	17	of	of	IN
cord-023417-by18aczt	80	18	patients	patient	NNS
cord-023417-by18aczt	80	19	with	with	IN
cord-023417-by18aczt	80	20	Sjögren	Sjögren	NNP
cord-023417-by18aczt	80	21	's	's	POS
cord-023417-by18aczt	80	22	syndrome	syndrome	NN
cord-023417-by18aczt	80	23	(	(	-LRB-
cord-023417-by18aczt	80	24	SS	SS	NNP
cord-023417-by18aczt	80	25	)	)	-RRB-
cord-023417-by18aczt	80	26	and	and	CC
cord-023417-by18aczt	80	27	appear	appear	VB
cord-023417-by18aczt	80	28	in	in	IN
cord-023417-by18aczt	80	29	both	both	DT
cord-023417-by18aczt	80	30	primary	primary	JJ
cord-023417-by18aczt	80	31	and	and	CC
cord-023417-by18aczt	80	32	secondary	secondary	JJ
cord-023417-by18aczt	80	33	SS	ss	NN
cord-023417-by18aczt	80	34	.	.	.
cord-023417-by18aczt	81	1	Previously	previously	RB
cord-023417-by18aczt	81	2	,	,	,
cord-023417-by18aczt	81	3	ectopic	ectopic	JJ
cord-023417-by18aczt	81	4	GC	GC	NNP
cord-023417-by18aczt	81	5	have	have	VBP
cord-023417-by18aczt	81	6	been	be	VBN
cord-023417-by18aczt	81	7	associated	associate	VBN
cord-023417-by18aczt	81	8	with	with	IN
cord-023417-by18aczt	81	9	increased	increase	VBN
cord-023417-by18aczt	81	10	local	local	JJ
cord-023417-by18aczt	81	11	autoantibody	autoantibody	NN
cord-023417-by18aczt	81	12	production	production	NN
cord-023417-by18aczt	81	13	.	.	.
cord-023417-by18aczt	82	1	The	the	DT
cord-023417-by18aczt	82	2	aim	aim	NN
cord-023417-by18aczt	82	3	of	of	IN
cord-023417-by18aczt	82	4	this	this	DT
cord-023417-by18aczt	82	5	study	study	NN
cord-023417-by18aczt	82	6	was	be	VBD
cord-023417-by18aczt	82	7	to	to	TO
cord-023417-by18aczt	82	8	determine	determine	VB
cord-023417-by18aczt	82	9	whether	whether	IN
cord-023417-by18aczt	82	10	GC	GC	NNP
cord-023417-by18aczt	82	11	in	in	IN
cord-023417-by18aczt	82	12	primary	primary	JJ
cord-023417-by18aczt	82	13	Sjögren	Sjögren	NNP
cord-023417-by18aczt	82	14	's	's	POS
cord-023417-by18aczt	82	15	syndrome	syndrome	NN
cord-023417-by18aczt	82	16	(	(	-LRB-
cord-023417-by18aczt	82	17	pSS	pSS	NNP
cord-023417-by18aczt	82	18	)	)	-RRB-
cord-023417-by18aczt	82	19	defines	define	VBZ
cord-023417-by18aczt	82	20	a	a	DT
cord-023417-by18aczt	82	21	distinct	distinct	JJ
cord-023417-by18aczt	82	22	seroimmunological	seroimmunological	JJ
cord-023417-by18aczt	82	23	phenotype	phenotype	NN
cord-023417-by18aczt	82	24	.	.	.
cord-023417-by18aczt	83	1	Retrospectively	retrospectively	RB
cord-023417-by18aczt	83	2	,	,	,
cord-023417-by18aczt	83	3	a	a	DT
cord-023417-by18aczt	83	4	material	material	NN
cord-023417-by18aczt	83	5	of	of	IN
cord-023417-by18aczt	83	6	130	130	CD
cord-023417-by18aczt	83	7	haematoxylin	haematoxylin	NN
cord-023417-by18aczt	83	8	and	and	CC
cord-023417-by18aczt	83	9	eosin	eosin	NN
cord-023417-by18aczt	83	10	-	-	HYPH
cord-023417-by18aczt	83	11	stained	stain	VBN
cord-023417-by18aczt	83	12	paraffin	paraffin	NN
cord-023417-by18aczt	83	13	-	-	HYPH
cord-023417-by18aczt	83	14	embedded	embed	VBN
cord-023417-by18aczt	83	15	tissue	tissue	NN
cord-023417-by18aczt	83	16	sections	section	NNS
cord-023417-by18aczt	83	17	of	of	IN
cord-023417-by18aczt	83	18	minor	minor	JJ
cord-023417-by18aczt	83	19	salivary	salivary	NN
cord-023417-by18aczt	83	20	gland	gland	NN
cord-023417-by18aczt	83	21	tissue	tissue	NN
cord-023417-by18aczt	83	22	from	from	IN
cord-023417-by18aczt	83	23	patients	patient	NNS
cord-023417-by18aczt	83	24	with	with	IN
cord-023417-by18aczt	83	25	pSS	pSS	NNP
cord-023417-by18aczt	83	26	was	be	VBD
cord-023417-by18aczt	83	27	morphologically	morphologically	RB
cord-023417-by18aczt	83	28	screened	screen	VBN
cord-023417-by18aczt	83	29	for	for	IN
cord-023417-by18aczt	83	30	the	the	DT
cord-023417-by18aczt	83	31	presence	presence	NN
cord-023417-by18aczt	83	32	of	of	IN
cord-023417-by18aczt	83	33	ectopic	ectopic	JJ
cord-023417-by18aczt	83	34	GC	GC	NNP
cord-023417-by18aczt	83	35	.	.	.
cord-023417-by18aczt	84	1	GC	GC	NNP
cord-023417-by18aczt	84	2	-	-	HYPH
cord-023417-by18aczt	84	3	like	like	JJ
cord-023417-by18aczt	84	4	lesions	lesion	NNS
cord-023417-by18aczt	84	5	were	be	VBD
cord-023417-by18aczt	84	6	detected	detect	VBN
cord-023417-by18aczt	84	7	in	in	IN
cord-023417-by18aczt	84	8	33/130	33/130	CD
cord-023417-by18aczt	84	9	(	(	-LRB-
cord-023417-by18aczt	84	10	25	25	CD
cord-023417-by18aczt	84	11	%	%	NN
cord-023417-by18aczt	84	12	)	)	-RRB-
cord-023417-by18aczt	84	13	of	of	IN
cord-023417-by18aczt	84	14	the	the	DT
cord-023417-by18aczt	84	15	pSS	pSS	NNP
cord-023417-by18aczt	84	16	patients	patient	NNS
cord-023417-by18aczt	84	17	.	.	.
cord-023417-by18aczt	85	1	Seventy	seventy	CD
cord-023417-by18aczt	85	2	-	-	HYPH
cord-023417-by18aczt	85	3	two	two	CD
cord-023417-by18aczt	85	4	pSS	ps	NNS
cord-023417-by18aczt	85	5	patients	patient	NNS
cord-023417-by18aczt	85	6	lacking	lack	VBG
cord-023417-by18aczt	85	7	these	these	DT
cord-023417-by18aczt	85	8	structures	structure	NNS
cord-023417-by18aczt	85	9	(	(	-LRB-
cord-023417-by18aczt	85	10	GC-	GC-	NNP
cord-023417-by18aczt	85	11	)	)	-RRB-
cord-023417-by18aczt	85	12	were	be	VBD
cord-023417-by18aczt	85	13	randomly	randomly	RB
cord-023417-by18aczt	85	14	selected	select	VBN
cord-023417-by18aczt	85	15	for	for	IN
cord-023417-by18aczt	85	16	comparison	comparison	NN
cord-023417-by18aczt	85	17	.	.	.
cord-023417-by18aczt	86	1	Focus	focus	JJ
cord-023417-by18aczt	86	2	score	score	NN
cord-023417-by18aczt	86	3	was	be	VBD
cord-023417-by18aczt	86	4	significantly	significantly	RB
cord-023417-by18aczt	86	5	increased	increase	VBN
cord-023417-by18aczt	86	6	in	in	IN
cord-023417-by18aczt	86	7	the	the	DT
cord-023417-by18aczt	86	8	GC	GC	NNP
cord-023417-by18aczt	86	9	þ	þ	CD
cord-023417-by18aczt	86	10	patients	patient	NNS
cord-023417-by18aczt	86	11	compared	compare	VBN
cord-023417-by18aczt	86	12	to	to	IN
cord-023417-by18aczt	86	13	the	the	DT
cord-023417-by18aczt	86	14	GCpatients	GCpatients	NNP
cord-023417-by18aczt	87	1	(	(	-LRB-
cord-023417-by18aczt	87	2	P	p	NN
cord-023417-by18aczt	87	3	¼	¼	CD
cord-023417-by18aczt	87	4	0.035	0.035	CD
cord-023417-by18aczt	87	5	)	)	-RRB-
cord-023417-by18aczt	87	6	.	.	.
cord-023417-by18aczt	88	1	In	in	IN
cord-023417-by18aczt	88	2	the	the	DT
cord-023417-by18aczt	88	3	GC	GC	NNP
cord-023417-by18aczt	88	4	þ	þ	NNP
cord-023417-by18aczt	88	5	group	group	NN
cord-023417-by18aczt	88	6	,	,	,
cord-023417-by18aczt	88	7	54.5	54.5	CD
cord-023417-by18aczt	88	8	%	%	NN
cord-023417-by18aczt	88	9	of	of	IN
cord-023417-by18aczt	88	10	the	the	DT
cord-023417-by18aczt	88	11	patients	patient	NNS
cord-023417-by18aczt	88	12	presented	present	VBN
cord-023417-by18aczt	88	13	with	with	IN
cord-023417-by18aczt	88	14	anti	anti	JJ
cord-023417-by18aczt	88	15	-	-	JJ
cord-023417-by18aczt	88	16	Ro	ro	JJ
cord-023417-by18aczt	88	17	/	/	SYM
cord-023417-by18aczt	88	18	SSA	SSA	NNP
cord-023417-by18aczt	88	19	compared	compare	VBN
cord-023417-by18aczt	88	20	to	to	IN
cord-023417-by18aczt	88	21	43.7	43.7	CD
cord-023417-by18aczt	88	22	%	%	NN
cord-023417-by18aczt	88	23	in	in	IN
cord-023417-by18aczt	88	24	the	the	DT
cord-023417-by18aczt	88	25	GCgroup	GCgroup	NNP
cord-023417-by18aczt	88	26	.	.	.
cord-023417-by18aczt	89	1	Anti	Anti	NNP
cord-023417-by18aczt	89	2	-	-	NNP
cord-023417-by18aczt	89	3	La	La	NNP
cord-023417-by18aczt	89	4	/	/	SYM
cord-023417-by18aczt	89	5	SSB	SSB	NNP
cord-023417-by18aczt	89	6	was	be	VBD
cord-023417-by18aczt	89	7	detected	detect	VBN
cord-023417-by18aczt	89	8	in	in	IN
cord-023417-by18aczt	89	9	31.3	31.3	CD
cord-023417-by18aczt	89	10	%	%	NN
cord-023417-by18aczt	89	11	of	of	IN
cord-023417-by18aczt	89	12	the	the	DT
cord-023417-by18aczt	89	13	GC	GC	NNP
cord-023417-by18aczt	89	14	þ	þ	CD
cord-023417-by18aczt	89	15	patients	patient	NNS
cord-023417-by18aczt	89	16	compared	compare	VBN
cord-023417-by18aczt	89	17	to	to	IN
cord-023417-by18aczt	89	18	25.7	25.7	CD
cord-023417-by18aczt	89	19	%	%	NN
cord-023417-by18aczt	89	20	of	of	IN
cord-023417-by18aczt	89	21	the	the	DT
cord-023417-by18aczt	89	22	GCpatients	GCpatients	NNP
cord-023417-by18aczt	89	23	.	.	.
cord-023417-by18aczt	90	1	Sixty	sixty	CD
cord-023417-by18aczt	90	2	-	-	HYPH
cord-023417-by18aczt	90	3	one	one	CD
cord-023417-by18aczt	90	4	percentage	percentage	NN
cord-023417-by18aczt	90	5	of	of	IN
cord-023417-by18aczt	90	6	GC	GC	NNP
cord-023417-by18aczt	90	7	þ	þ	NNP
cord-023417-by18aczt	90	8	patients	patient	NNS
cord-023417-by18aczt	90	9	presented	present	VBN
cord-023417-by18aczt	90	10	with	with	IN
cord-023417-by18aczt	90	11	increased	increase	VBN
cord-023417-by18aczt	90	12	levels	level	NNS
cord-023417-by18aczt	90	13	of	of	IN
cord-023417-by18aczt	90	14	IgG	IgG	NNP
cord-023417-by18aczt	90	15	,	,	,
cord-023417-by18aczt	90	16	a	a	DT
cord-023417-by18aczt	90	17	nonsignificant	nonsignificant	JJ
cord-023417-by18aczt	90	18	difference	difference	NN
cord-023417-by18aczt	90	19	when	when	WRB
cord-023417-by18aczt	90	20	compared	compare	VBN
cord-023417-by18aczt	90	21	to	to	IN
cord-023417-by18aczt	90	22	39.4	39.4	CD
cord-023417-by18aczt	90	23	%	%	NN
cord-023417-by18aczt	90	24	in	in	IN
cord-023417-by18aczt	90	25	the	the	DT
cord-023417-by18aczt	90	26	GCpatients	GCpatients	NNP
cord-023417-by18aczt	91	1	(	(	-LRB-
cord-023417-by18aczt	91	2	P	p	NN
cord-023417-by18aczt	91	3	¼	¼	NNP
cord-023417-by18aczt	91	4	0.089	0.089	CD
cord-023417-by18aczt	91	5	)	)	-RRB-
cord-023417-by18aczt	91	6	.	.	.
cord-023417-by18aczt	92	1	Levels	level	NNS
cord-023417-by18aczt	92	2	of	of	IN
cord-023417-by18aczt	92	3	RF	RF	NNP
cord-023417-by18aczt	92	4	,	,	,
cord-023417-by18aczt	92	5	ANA	ANA	NNP
cord-023417-by18aczt	92	6	,	,	,
cord-023417-by18aczt	92	7	ENA	ENA	NNP
cord-023417-by18aczt	92	8	,	,	,
cord-023417-by18aczt	92	9	IgM	IgM	NNP
cord-023417-by18aczt	92	10	and	and	CC
cord-023417-by18aczt	92	11	IgA	IgA	NNP
cord-023417-by18aczt	92	12	were	be	VBD
cord-023417-by18aczt	92	13	similar	similar	JJ
cord-023417-by18aczt	92	14	in	in	IN
cord-023417-by18aczt	92	15	both	both	DT
cord-023417-by18aczt	92	16	patient	patient	JJ
cord-023417-by18aczt	92	17	groups	group	NNS
cord-023417-by18aczt	92	18	,	,	,
cord-023417-by18aczt	92	19	as	as	IN
cord-023417-by18aczt	92	20	were	be	VBD
cord-023417-by18aczt	92	21	ESR	ESR	NNP
cord-023417-by18aczt	92	22	and	and	CC
cord-023417-by18aczt	92	23	CRP	CRP	NNP
cord-023417-by18aczt	92	24	.	.	.
cord-023417-by18aczt	93	1	In	in	IN
cord-023417-by18aczt	93	2	conclusion	conclusion	NN
cord-023417-by18aczt	93	3	,	,	,
cord-023417-by18aczt	93	4	patients	patient	NNS
cord-023417-by18aczt	93	5	with	with	IN
cord-023417-by18aczt	93	6	ectopic	ectopic	JJ
cord-023417-by18aczt	93	7	GC	GC	NNP
cord-023417-by18aczt	93	8	have	have	VBP
cord-023417-by18aczt	93	9	a	a	DT
cord-023417-by18aczt	93	10	higher	high	JJR
cord-023417-by18aczt	93	11	focus	focus	NN
cord-023417-by18aczt	93	12	score	score	NN
cord-023417-by18aczt	93	13	and	and	CC
cord-023417-by18aczt	93	14	more	more	RBR
cord-023417-by18aczt	93	15	often	often	RB
cord-023417-by18aczt	93	16	present	present	JJ
cord-023417-by18aczt	93	17	with	with	IN
cord-023417-by18aczt	93	18	autoantibodies	autoantibody	NNS
cord-023417-by18aczt	93	19	and	and	CC
cord-023417-by18aczt	93	20	increased	increase	VBN
cord-023417-by18aczt	93	21	levels	level	NNS
cord-023417-by18aczt	93	22	of	of	IN
cord-023417-by18aczt	93	23	IgG	igg	NN
cord-023417-by18aczt	93	24	compared	compare	VBN
cord-023417-by18aczt	93	25	to	to	IN
cord-023417-by18aczt	93	26	pSS	pSS	NNP
cord-023417-by18aczt	93	27	patients	patient	NNS
cord-023417-by18aczt	93	28	with	with	IN
cord-023417-by18aczt	93	29	regular	regular	JJ
cord-023417-by18aczt	93	30	focal	focal	JJ
cord-023417-by18aczt	93	31	infiltration	infiltration	NN
cord-023417-by18aczt	93	32	(	(	-LRB-
cord-023417-by18aczt	93	33	GC	GC	NNP
cord-023417-by18aczt	93	34	-	-	,
cord-023417-by18aczt	93	35	)	)	-RRB-
cord-023417-by18aczt	93	36	.	.	.
cord-023417-by18aczt	94	1	Our	-PRON-	PRP$
cord-023417-by18aczt	94	2	findings	finding	NNS
cord-023417-by18aczt	94	3	may	may	MD
cord-023417-by18aczt	94	4	indicate	indicate	VB
cord-023417-by18aczt	94	5	a	a	DT
cord-023417-by18aczt	94	6	certain	certain	JJ
cord-023417-by18aczt	94	7	seroimmunological	seroimmunological	JJ
cord-023417-by18aczt	94	8	phenotype	phenotype	NN
cord-023417-by18aczt	94	9	and	and	CC
cord-023417-by18aczt	94	10	warrant	warrant	VB
cord-023417-by18aczt	94	11	for	for	IN
cord-023417-by18aczt	94	12	further	further	JJ
cord-023417-by18aczt	94	13	prospective	prospective	JJ
cord-023417-by18aczt	94	14	studies	study	NNS
cord-023417-by18aczt	94	15	.	.	.
cord-023417-by18aczt	95	1	Association	association	NN
cord-023417-by18aczt	95	2	between	between	IN
cord-023417-by18aczt	95	3	Mannose	Mannose	NNP
cord-023417-by18aczt	95	4	-	-	HYPH
cord-023417-by18aczt	95	5	Binding	bind	VBG
cord-023417-by18aczt	95	6	Lectin	Lectin	NNP
cord-023417-by18aczt	95	7	and	and	CC
cord-023417-by18aczt	95	8	Vascular	Vascular	NNP
cord-023417-by18aczt	95	9	Complications	Complications	NNPS
cord-023417-by18aczt	95	10	in	in	IN
cord-023417-by18aczt	95	11	Type	type	NN
cord-023417-by18aczt	95	12	1	1	CD
cord-023417-by18aczt	95	13	Diabetes	diabetes	NN
cord-023417-by18aczt	95	14	Complement	Complement	NNP
cord-023417-by18aczt	95	15	activation	activation	NN
cord-023417-by18aczt	95	16	and	and	CC
cord-023417-by18aczt	95	17	inflammation	inflammation	NN
cord-023417-by18aczt	95	18	have	have	VBP
cord-023417-by18aczt	95	19	been	be	VBN
cord-023417-by18aczt	95	20	suggested	suggest	VBN
cord-023417-by18aczt	95	21	in	in	IN
cord-023417-by18aczt	95	22	the	the	DT
cord-023417-by18aczt	95	23	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	95	24	of	of	IN
cord-023417-by18aczt	95	25	diabetic	diabetic	JJ
cord-023417-by18aczt	95	26	vascular	vascular	JJ
cord-023417-by18aczt	95	27	lesions	lesion	NNS
cord-023417-by18aczt	95	28	.	.	.
cord-023417-by18aczt	96	1	We	-PRON-	PRP
cord-023417-by18aczt	96	2	investigated	investigate	VBD
cord-023417-by18aczt	96	3	serum	serum	NN
cord-023417-by18aczt	96	4	mannose	mannose	NN
cord-023417-by18aczt	96	5	-	-	HYPH
cord-023417-by18aczt	96	6	binding	bind	VBG
cord-023417-by18aczt	96	7	lectin	lectin	NN
cord-023417-by18aczt	96	8	(	(	-LRB-
cord-023417-by18aczt	96	9	MBL	MBL	NNP
cord-023417-by18aczt	96	10	)	)	-RRB-
cord-023417-by18aczt	96	11	levels	level	NNS
cord-023417-by18aczt	96	12	and	and	CC
cord-023417-by18aczt	96	13	polymorphisms	polymorphism	NNS
cord-023417-by18aczt	96	14	in	in	IN
cord-023417-by18aczt	96	15	the	the	DT
cord-023417-by18aczt	96	16	MBL	MBL	NNP
cord-023417-by18aczt	96	17	gene	gene	NN
cord-023417-by18aczt	96	18	in	in	IN
cord-023417-by18aczt	96	19	type	type	NN
cord-023417-by18aczt	96	20	1	1	CD
cord-023417-by18aczt	96	21	diabetic	diabetic	JJ
cord-023417-by18aczt	96	22	(	(	-LRB-
cord-023417-by18aczt	96	23	T1DM	T1DM	NNP
cord-023417-by18aczt	96	24	)	)	-RRB-
cord-023417-by18aczt	96	25	patients	patient	NNS
cord-023417-by18aczt	96	26	with	with	IN
cord-023417-by18aczt	96	27	and	and	CC
cord-023417-by18aczt	96	28	without	without	IN
cord-023417-by18aczt	96	29	diabetic	diabetic	JJ
cord-023417-by18aczt	96	30	nephropathy	nephropathy	NN
cord-023417-by18aczt	96	31	and	and	CC
cord-023417-by18aczt	96	32	associated	associate	VBD
cord-023417-by18aczt	96	33	macrovascular	macrovascular	JJ
cord-023417-by18aczt	96	34	complications	complication	NNS
cord-023417-by18aczt	96	35	.	.	.
cord-023417-by18aczt	97	1	Polymorphisms	polymorphism	NNS
cord-023417-by18aczt	97	2	in	in	IN
cord-023417-by18aczt	97	3	the	the	DT
cord-023417-by18aczt	97	4	MBL	MBL	NNP
cord-023417-by18aczt	97	5	gene	gene	NN
cord-023417-by18aczt	97	6	and	and	CC
cord-023417-by18aczt	97	7	serum	serum	NN
cord-023417-by18aczt	97	8	MBL	MBL	NNP
cord-023417-by18aczt	97	9	levels	level	NNS
cord-023417-by18aczt	97	10	were	be	VBD
cord-023417-by18aczt	97	11	determined	determine	VBN
cord-023417-by18aczt	97	12	in	in	IN
cord-023417-by18aczt	97	13	199	199	CD
cord-023417-by18aczt	97	14	T1DM	T1DM	NNP
cord-023417-by18aczt	97	15	patients	patient	NNS
cord-023417-by18aczt	97	16	with	with	IN
cord-023417-by18aczt	97	17	overt	overt	JJ
cord-023417-by18aczt	97	18	nephropathy	nephropathy	NN
cord-023417-by18aczt	97	19	and	and	CC
cord-023417-by18aczt	97	20	192	192	CD
cord-023417-by18aczt	97	21	T1DM	T1DM	NNP
cord-023417-by18aczt	97	22	patients	patient	NNS
cord-023417-by18aczt	97	23	with	with	IN
cord-023417-by18aczt	97	24	persistent	persistent	JJ
cord-023417-by18aczt	97	25	normoalbuminuria	normoalbuminuria	NNP
cord-023417-by18aczt	97	26	matched	match	VBN
cord-023417-by18aczt	97	27	for	for	IN
cord-023417-by18aczt	97	28	age	age	NN
cord-023417-by18aczt	97	29	,	,	,
cord-023417-by18aczt	97	30	sex	sex	NN
cord-023417-by18aczt	97	31	and	and	CC
cord-023417-by18aczt	97	32	duration	duration	NN
cord-023417-by18aczt	97	33	of	of	IN
cord-023417-by18aczt	97	34	diabetes	diabete	NNS
cord-023417-by18aczt	97	35	as	as	RB
cord-023417-by18aczt	97	36	well	well	RB
cord-023417-by18aczt	97	37	as	as	IN
cord-023417-by18aczt	97	38	in	in	IN
cord-023417-by18aczt	97	39	100	100	CD
cord-023417-by18aczt	97	40	healthy	healthy	JJ
cord-023417-by18aczt	97	41	control	control	NN
cord-023417-by18aczt	97	42	subjects	subject	NNS
cord-023417-by18aczt	97	43	.	.	.
cord-023417-by18aczt	98	1	The	the	DT
cord-023417-by18aczt	98	2	frequencies	frequency	NNS
cord-023417-by18aczt	98	3	of	of	IN
cord-023417-by18aczt	98	4	high	high	JJ
cord-023417-by18aczt	98	5	and	and	CC
cord-023417-by18aczt	98	6	low	low	JJ
cord-023417-by18aczt	98	7	expression	expression	NN
cord-023417-by18aczt	98	8	MBL	MBL	NNP
cord-023417-by18aczt	98	9	genotypes	genotype	NNS
cord-023417-by18aczt	98	10	were	be	VBD
cord-023417-by18aczt	98	11	similar	similar	JJ
cord-023417-by18aczt	98	12	in	in	IN
cord-023417-by18aczt	98	13	patients	patient	NNS
cord-023417-by18aczt	98	14	with	with	IN
cord-023417-by18aczt	98	15	T1DM	t1dm	JJ
cord-023417-by18aczt	98	16	and	and	CC
cord-023417-by18aczt	98	17	healthy	healthy	JJ
cord-023417-by18aczt	98	18	controls	control	NNS
cord-023417-by18aczt	98	19	.	.	.
cord-023417-by18aczt	99	1	High	high	JJ
cord-023417-by18aczt	99	2	MBL	MBL	NNP
cord-023417-by18aczt	99	3	genotypes	genotype	NNS
cord-023417-by18aczt	99	4	were	be	VBD
cord-023417-by18aczt	99	5	significantly	significantly	RB
cord-023417-by18aczt	99	6	more	more	RBR
cord-023417-by18aczt	99	7	frequent	frequent	JJ
cord-023417-by18aczt	99	8	in	in	IN
cord-023417-by18aczt	99	9	diabetic	diabetic	JJ
cord-023417-by18aczt	99	10	patients	patient	NNS
cord-023417-by18aczt	99	11	with	with	IN
cord-023417-by18aczt	99	12	nephropathy	nephropathy	NN
cord-023417-by18aczt	99	13	than	than	IN
cord-023417-by18aczt	99	14	in	in	IN
cord-023417-by18aczt	99	15	the	the	DT
cord-023417-by18aczt	99	16	normoalbuminuric	normoalbuminuric	NNP
cord-023417-by18aczt	99	17	group	group	NN
cord-023417-by18aczt	99	18	,	,	,
cord-023417-by18aczt	99	19	and	and	CC
cord-023417-by18aczt	99	20	the	the	DT
cord-023417-by18aczt	99	21	risk	risk	NN
cord-023417-by18aczt	99	22	of	of	IN
cord-023417-by18aczt	99	23	having	have	VBG
cord-023417-by18aczt	99	24	nephropathy	nephropathy	NN
cord-023417-by18aczt	99	25	,	,	,
cord-023417-by18aczt	99	26	given	give	VBN
cord-023417-by18aczt	99	27	a	a	DT
cord-023417-by18aczt	99	28	high	high	JJ
cord-023417-by18aczt	99	29	MBL	MBL	NNP
cord-023417-by18aczt	99	30	genotype	genotype	NN
cord-023417-by18aczt	99	31	,	,	,
cord-023417-by18aczt	99	32	assessed	assess	VBN
cord-023417-by18aczt	99	33	by	by	IN
cord-023417-by18aczt	99	34	odds	odd	NNS
cord-023417-by18aczt	99	35	ratio	ratio	NN
cord-023417-by18aczt	99	36	was	be	VBD
cord-023417-by18aczt	99	37	1.52	1.52	CD
cord-023417-by18aczt	99	38	(	(	-LRB-
cord-023417-by18aczt	99	39	1.02	1.02	CD
cord-023417-by18aczt	99	40	-	-	SYM
cord-023417-by18aczt	99	41	2.27	2.27	CD
cord-023417-by18aczt	99	42	)	)	-RRB-
cord-023417-by18aczt	99	43	,	,	,
cord-023417-by18aczt	99	44	P	p	NN
cord-023417-by18aczt	99	45	¼	¼	CD
cord-023417-by18aczt	99	46	0.04	0.04	CD
cord-023417-by18aczt	99	47	.	.	.
cord-023417-by18aczt	100	1	Median	median	JJ
cord-023417-by18aczt	100	2	serum	serum	NN
cord-023417-by18aczt	100	3	MBL	MBL	NNP
cord-023417-by18aczt	100	4	concentrations	concentration	NNS
cord-023417-by18aczt	100	5	were	be	VBD
cord-023417-by18aczt	100	6	significantly	significantly	RB
cord-023417-by18aczt	100	7	higher	high	JJR
cord-023417-by18aczt	100	8	in	in	IN
cord-023417-by18aczt	100	9	patients	patient	NNS
cord-023417-by18aczt	100	10	with	with	IN
cord-023417-by18aczt	100	11	nephropathy	nephropathy	NN
cord-023417-by18aczt	100	12	than	than	IN
cord-023417-by18aczt	100	13	in	in	IN
cord-023417-by18aczt	100	14	patients	patient	NNS
cord-023417-by18aczt	100	15	with	with	IN
cord-023417-by18aczt	100	16	normoalbuminuria	normoalbuminuria	NNP
cord-023417-by18aczt	101	1	[	[	-LRB-
cord-023417-by18aczt	101	2	2306	2306	CD
cord-023417-by18aczt	101	3	mg	mg	NNP
cord-023417-by18aczt	101	4	/	/	SYM
cord-023417-by18aczt	101	5	l	l	NN
cord-023417-by18aczt	101	6	(	(	-LRB-
cord-023417-by18aczt	101	7	IQR	IQR	NNP
cord-023417-by18aczt	101	8	753	753	CD
cord-023417-by18aczt	101	9	-	-	HYPH
cord-023417-by18aczt	101	10	4867	4867	CD
cord-023417-by18aczt	101	11	mg	mg	NNP
cord-023417-by18aczt	101	12	/	/	SYM
cord-023417-by18aczt	101	13	l	l	NNP
cord-023417-by18aczt	101	14	)	)	-RRB-
cord-023417-by18aczt	101	15	versus	versus	IN
cord-023417-by18aczt	101	16	1491	1491	CD
cord-023417-by18aczt	101	17	mg	mg	NNP
cord-023417-by18aczt	101	18	/	/	SYM
cord-023417-by18aczt	101	19	l	l	NN
cord-023417-by18aczt	101	20	(	(	-LRB-
cord-023417-by18aczt	101	21	IQR	IQR	NNP
cord-023417-by18aczt	101	22	577	577	CD
cord-023417-by18aczt	101	23	-	-	HYPH
cord-023417-by18aczt	101	24	2944	2944	CD
cord-023417-by18aczt	101	25	)	)	-RRB-
cord-023417-by18aczt	101	26	,	,	,
cord-023417-by18aczt	101	27	P	p	NN
cord-023417-by18aczt	101	28	¼	¼	CD
cord-023417-by18aczt	101	29	0.0003	0.0003	CD
cord-023417-by18aczt	101	30	]	]	-RRB-
cord-023417-by18aczt	101	31	,	,	,
cord-023417-by18aczt	101	32	and	and	CC
cord-023417-by18aczt	101	33	even	even	RB
cord-023417-by18aczt	101	34	when	when	WRB
cord-023417-by18aczt	101	35	comparing	compare	VBG
cord-023417-by18aczt	101	36	patients	patient	NNS
cord-023417-by18aczt	101	37	with	with	IN
cord-023417-by18aczt	101	38	identical	identical	JJ
cord-023417-by18aczt	101	39	genotypes	genotype	NNS
cord-023417-by18aczt	101	40	,	,	,
cord-023417-by18aczt	101	41	serum	serum	NN
cord-023417-by18aczt	101	42	MBL	MBL	NNP
cord-023417-by18aczt	101	43	levels	level	NNS
cord-023417-by18aczt	101	44	were	be	VBD
cord-023417-by18aczt	101	45	higher	high	JJR
cord-023417-by18aczt	101	46	in	in	IN
cord-023417-by18aczt	101	47	the	the	DT
cord-023417-by18aczt	101	48	nephropathy	nephropathy	NN
cord-023417-by18aczt	101	49	group	group	NN
cord-023417-by18aczt	101	50	than	than	IN
cord-023417-by18aczt	101	51	in	in	IN
cord-023417-by18aczt	101	52	the	the	DT
cord-023417-by18aczt	101	53	normoalbuminuric	normoalbuminuric	NNP
cord-023417-by18aczt	101	54	group	group	NN
cord-023417-by18aczt	101	55	.	.	.
cord-023417-by18aczt	102	1	Patients	patient	NNS
cord-023417-by18aczt	102	2	with	with	IN
cord-023417-by18aczt	102	3	a	a	DT
cord-023417-by18aczt	102	4	history	history	NN
cord-023417-by18aczt	102	5	of	of	IN
cord-023417-by18aczt	102	6	cardiovascular	cardiovascular	JJ
cord-023417-by18aczt	102	7	disease	disease	NN
cord-023417-by18aczt	102	8	had	have	VBD
cord-023417-by18aczt	102	9	significantly	significantly	RB
cord-023417-by18aczt	102	10	elevated	elevate	VBN
cord-023417-by18aczt	102	11	MBL	MBL	NNP
cord-023417-by18aczt	102	12	levels	level	NNS
cord-023417-by18aczt	102	13	independently	independently	RB
cord-023417-by18aczt	102	14	of	of	IN
cord-023417-by18aczt	102	15	nephropathy	nephropathy	NN
cord-023417-by18aczt	102	16	status	status	NN
cord-023417-by18aczt	102	17	[	[	-LRB-
cord-023417-by18aczt	102	18	3178	3178	CD
cord-023417-by18aczt	102	19	mg	mg	NNP
cord-023417-by18aczt	102	20	/	/	SYM
cord-023417-by18aczt	102	21	l	l	NN
cord-023417-by18aczt	102	22	(	(	-LRB-
cord-023417-by18aczt	102	23	IQR	IQR	NNP
cord-023417-by18aczt	102	24	636	636	CD
cord-023417-by18aczt	102	25	-	-	HYPH
cord-023417-by18aczt	102	26	5231	5231	CD
cord-023417-by18aczt	102	27	mg	mg	NNP
cord-023417-by18aczt	102	28	/	/	SYM
cord-023417-by18aczt	102	29	l	l	NNP
cord-023417-by18aczt	102	30	)	)	-RRB-
cord-023417-by18aczt	102	31	versus	versus	IN
cord-023417-by18aczt	102	32	1741	1741	CD
cord-023417-by18aczt	102	33	mg	mg	NNP
cord-023417-by18aczt	102	34	/	/	SYM
cord-023417-by18aczt	102	35	l	l	NN
cord-023417-by18aczt	102	36	(	(	-LRB-
cord-023417-by18aczt	102	37	IQR	IQR	NNP
cord-023417-by18aczt	102	38	656	656	CD
cord-023417-by18aczt	102	39	-	-	HYPH
cord-023417-by18aczt	102	40	3149	3149	CD
cord-023417-by18aczt	102	41	mg	mg	NNP
cord-023417-by18aczt	102	42	/	/	SYM
cord-023417-by18aczt	102	43	l	l	NNP
cord-023417-by18aczt	102	44	)	)	-RRB-
cord-023417-by18aczt	102	45	,	,	,
cord-023417-by18aczt	102	46	P	p	NN
cord-023417-by18aczt	102	47	¼	¼	CD
cord-023417-by18aczt	102	48	0.02	0.02	CD
cord-023417-by18aczt	102	49	]	]	-RRB-
cord-023417-by18aczt	102	50	.	.	.
cord-023417-by18aczt	103	1	The	the	DT
cord-023417-by18aczt	103	2	differences	difference	NNS
cord-023417-by18aczt	103	3	in	in	IN
cord-023417-by18aczt	103	4	MBL	MBL	NNP
cord-023417-by18aczt	103	5	levels	level	NNS
cord-023417-by18aczt	103	6	between	between	IN
cord-023417-by18aczt	103	7	patients	patient	NNS
cord-023417-by18aczt	103	8	with	with	IN
cord-023417-by18aczt	103	9	and	and	CC
cord-023417-by18aczt	103	10	without	without	IN
cord-023417-by18aczt	103	11	vascular	vascular	JJ
cord-023417-by18aczt	103	12	complications	complication	NNS
cord-023417-by18aczt	103	13	were	be	VBD
cord-023417-by18aczt	103	14	driven	drive	VBN
cord-023417-by18aczt	103	15	primarily	primarily	RB
cord-023417-by18aczt	103	16	by	by	IN
cord-023417-by18aczt	103	17	pronounced	pronounce	VBN
cord-023417-by18aczt	103	18	differences	difference	NNS
cord-023417-by18aczt	103	19	among	among	IN
cord-023417-by18aczt	103	20	carriers	carrier	NNS
cord-023417-by18aczt	103	21	of	of	IN
cord-023417-by18aczt	103	22	high	high	JJ
cord-023417-by18aczt	103	23	MBL	MBL	NNP
cord-023417-by18aczt	103	24	genotypes	genotype	NNS
cord-023417-by18aczt	103	25	(	(	-LRB-
cord-023417-by18aczt	103	26	P	p	NN
cord-023417-by18aczt	103	27	<	<	XX
cord-023417-by18aczt	103	28	0.0001	0.0001	CD
cord-023417-by18aczt	103	29	)	)	-RRB-
cord-023417-by18aczt	103	30	.	.	.
cord-023417-by18aczt	104	1	Our	-PRON-	PRP$
cord-023417-by18aczt	104	2	findings	finding	NNS
cord-023417-by18aczt	104	3	suggest	suggest	VBP
cord-023417-by18aczt	104	4	that	that	IN
cord-023417-by18aczt	104	5	MBL	MBL	NNP
cord-023417-by18aczt	104	6	may	may	MD
cord-023417-by18aczt	104	7	be	be	VB
cord-023417-by18aczt	104	8	involved	involve	VBN
cord-023417-by18aczt	104	9	in	in	IN
cord-023417-by18aczt	104	10	the	the	DT
cord-023417-by18aczt	104	11	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	104	12	of	of	IN
cord-023417-by18aczt	104	13	microvascular	microvascular	JJ
cord-023417-by18aczt	104	14	and	and	CC
cord-023417-by18aczt	104	15	macrovascular	macrovascular	JJ
cord-023417-by18aczt	104	16	complications	complication	NNS
cord-023417-by18aczt	104	17	in	in	IN
cord-023417-by18aczt	104	18	type	type	NN
cord-023417-by18aczt	104	19	1	1	CD
cord-023417-by18aczt	104	20	diabetes	diabetes	NN
cord-023417-by18aczt	104	21	and	and	CC
cord-023417-by18aczt	104	22	that	that	DT
cord-023417-by18aczt	104	23	determination	determination	NN
cord-023417-by18aczt	104	24	of	of	IN
cord-023417-by18aczt	104	25	MBL	MBL	NNP
cord-023417-by18aczt	104	26	status	status	NN
cord-023417-by18aczt	104	27	might	may	MD
cord-023417-by18aczt	104	28	be	be	VB
cord-023417-by18aczt	104	29	used	use	VBN
cord-023417-by18aczt	104	30	to	to	TO
cord-023417-by18aczt	104	31	identify	identify	VB
cord-023417-by18aczt	104	32	patients	patient	NNS
cord-023417-by18aczt	104	33	at	at	IN
cord-023417-by18aczt	104	34	increased	increase	VBN
cord-023417-by18aczt	104	35	risk	risk	NN
cord-023417-by18aczt	104	36	of	of	IN
cord-023417-by18aczt	104	37	developing	develop	VBG
cord-023417-by18aczt	104	38	these	these	DT
cord-023417-by18aczt	104	39	complications	complication	NNS
cord-023417-by18aczt	104	40	.	.	.
cord-023417-by18aczt	105	1	Neuroimmunology	Neuroimmunology	NNP
cord-023417-by18aczt	105	2	Unit	Unit	NNP
cord-023417-by18aczt	105	3	,	,	,
cord-023417-by18aczt	105	4	Center	Center	NNP
cord-023417-by18aczt	105	5	for	for	IN
cord-023417-by18aczt	105	6	Molecular	Molecular	NNP
cord-023417-by18aczt	105	7	Medicine	Medicine	NNP
cord-023417-by18aczt	105	8	,	,	,
cord-023417-by18aczt	105	9	Karolinska	Karolinska	NNP
cord-023417-by18aczt	105	10	Institutet	Institutet	NNP
cord-023417-by18aczt	105	11	,	,	,
cord-023417-by18aczt	105	12	Stockholm	Stockholm	NNP
cord-023417-by18aczt	105	13	,	,	,
cord-023417-by18aczt	105	14	Sweden	Sweden	NNP
cord-023417-by18aczt	105	15	.	.	.
cord-023417-by18aczt	106	1	E	e	NN
cord-023417-by18aczt	106	2	-	-	NN
cord-023417-by18aczt	106	3	mail	mail	NN
cord-023417-by18aczt	106	4	:	:	:
cord-023417-by18aczt	107	1	judit.wefer@cmm.ki.se	judit.wefer@cmm.ki.se	JJ
cord-023417-by18aczt	107	2	DNA	dna	NN
cord-023417-by18aczt	107	3	vaccine	vaccine	NN
cord-023417-by18aczt	107	4	coding	code	VBG
cord-023417-by18aczt	107	5	for	for	IN
cord-023417-by18aczt	107	6	the	the	DT
cord-023417-by18aczt	107	7	encephalitogenic	encephalitogenic	NNP
cord-023417-by18aczt	107	8	peptide	peptide	NN
cord-023417-by18aczt	107	9	MOG	MOG	NNP
cord-023417-by18aczt	107	10	91	91	CD
cord-023417-by18aczt	107	11	-	-	HYPH
cord-023417-by18aczt	107	12	108	108	CD
cord-023417-by18aczt	107	13	protects	protect	VBZ
cord-023417-by18aczt	107	14	LEW.1AV1	lew.1av1	RB
cord-023417-by18aczt	107	15	from	from	IN
cord-023417-by18aczt	107	16	subsequent	subsequent	JJ
cord-023417-by18aczt	107	17	development	development	NN
cord-023417-by18aczt	107	18	of	of	IN
cord-023417-by18aczt	107	19	experimental	experimental	JJ
cord-023417-by18aczt	107	20	autoimmune	autoimmune	JJ
cord-023417-by18aczt	107	21	encephalomyelitis	encephalomyelitis	NN
cord-023417-by18aczt	107	22	(	(	-LRB-
cord-023417-by18aczt	107	23	EAE	EAE	NNP
cord-023417-by18aczt	107	24	)	)	-RRB-
cord-023417-by18aczt	107	25	.	.	.
cord-023417-by18aczt	108	1	Protection	protection	NN
cord-023417-by18aczt	108	2	is	be	VBZ
cord-023417-by18aczt	108	3	associated	associate	VBN
cord-023417-by18aczt	108	4	with	with	IN
cord-023417-by18aczt	108	5	a	a	DT
cord-023417-by18aczt	108	6	type	type	NN
cord-023417-by18aczt	108	7	1	1	CD
cord-023417-by18aczt	108	8	immune	immune	JJ
cord-023417-by18aczt	108	9	response	response	NN
cord-023417-by18aczt	108	10	and	and	CC
cord-023417-by18aczt	108	11	is	be	VBZ
cord-023417-by18aczt	108	12	dependent	dependent	JJ
cord-023417-by18aczt	108	13	on	on	IN
cord-023417-by18aczt	108	14	the	the	DT
cord-023417-by18aczt	108	15	presence	presence	NN
cord-023417-by18aczt	108	16	of	of	IN
cord-023417-by18aczt	108	17	CpG	CpG	NNP
cord-023417-by18aczt	108	18	DNA	DNA	NNP
cord-023417-by18aczt	108	19	motifs	motif	NNS
cord-023417-by18aczt	108	20	.	.	.
cord-023417-by18aczt	109	1	The	the	DT
cord-023417-by18aczt	109	2	mechanisms	mechanism	NNS
cord-023417-by18aczt	109	3	underlying	underlie	VBG
cord-023417-by18aczt	109	4	the	the	DT
cord-023417-by18aczt	109	5	observed	observed	JJ
cord-023417-by18aczt	109	6	reduction	reduction	NN
cord-023417-by18aczt	109	7	of	of	IN
cord-023417-by18aczt	109	8	EAE	EAE	NNP
cord-023417-by18aczt	109	9	development	development	NN
cord-023417-by18aczt	109	10	in	in	IN
cord-023417-by18aczt	109	11	protected	protect	VBN
cord-023417-by18aczt	109	12	rats	rat	NNS
cord-023417-by18aczt	109	13	have	have	VBP
cord-023417-by18aczt	109	14	not	not	RB
cord-023417-by18aczt	109	15	been	be	VBN
cord-023417-by18aczt	109	16	fully	fully	RB
cord-023417-by18aczt	109	17	clarified	clarify	VBN
cord-023417-by18aczt	109	18	.	.	.
cord-023417-by18aczt	110	1	We	-PRON-	PRP
cord-023417-by18aczt	110	2	investigated	investigate	VBD
cord-023417-by18aczt	110	3	immunological	immunological	JJ
cord-023417-by18aczt	110	4	characteristics	characteristic	NNS
cord-023417-by18aczt	110	5	of	of	IN
cord-023417-by18aczt	110	6	lymphocytes	lymphocyte	NNS
cord-023417-by18aczt	110	7	after	after	IN
cord-023417-by18aczt	110	8	DNA	dna	NN
cord-023417-by18aczt	110	9	vaccinaton	vaccinaton	NN
cord-023417-by18aczt	110	10	and	and	CC
cord-023417-by18aczt	110	11	subsequent	subsequent	JJ
cord-023417-by18aczt	110	12	EAE	EAE	NNP
cord-023417-by18aczt	110	13	induction	induction	NN
cord-023417-by18aczt	110	14	.	.	.
cord-023417-by18aczt	111	1	We	-PRON-	PRP
cord-023417-by18aczt	111	2	confirm	confirm	VBP
cord-023417-by18aczt	111	3	that	that	IN
cord-023417-by18aczt	111	4	protection	protection	NN
cord-023417-by18aczt	111	5	was	be	VBD
cord-023417-by18aczt	111	6	not	not	RB
cord-023417-by18aczt	111	7	associated	associate	VBN
cord-023417-by18aczt	111	8	with	with	IN
cord-023417-by18aczt	111	9	suppression	suppression	NN
cord-023417-by18aczt	111	10	of	of	IN
cord-023417-by18aczt	111	11	T1	t1	NN
cord-023417-by18aczt	111	12	cells	cell	NNS
cord-023417-by18aczt	111	13	,	,	,
cord-023417-by18aczt	111	14	as	as	IN
cord-023417-by18aczt	111	15	transcription	transcription	NN
cord-023417-by18aczt	111	16	of	of	IN
cord-023417-by18aczt	111	17	the	the	DT
cord-023417-by18aczt	111	18	novel	novel	JJ
cord-023417-by18aczt	111	19	molecule	molecule	NN
cord-023417-by18aczt	111	20	rat	rat	NN
cord-023417-by18aczt	111	21	T	t	NN
cord-023417-by18aczt	111	22	-	-	HYPH
cord-023417-by18aczt	111	23	cell	cell	NN
cord-023417-by18aczt	111	24	immunoglobulin	immunoglobulin	NN
cord-023417-by18aczt	111	25	-	-	:
cord-023417-by18aczt	111	26	and	and	CC
cord-023417-by18aczt	111	27	mucindomain	mucindomain	NN
cord-023417-by18aczt	111	28	-	-	HYPH
cord-023417-by18aczt	111	29	containing	contain	VBG
cord-023417-by18aczt	111	30	molecule	molecule	NN
cord-023417-by18aczt	111	31	(	(	-LRB-
cord-023417-by18aczt	111	32	TIM-3	TIM-3	NNP
cord-023417-by18aczt	111	33	)	)	-RRB-
cord-023417-by18aczt	111	34	,	,	,
cord-023417-by18aczt	111	35	reported	report	VBN
cord-023417-by18aczt	111	36	to	to	TO
cord-023417-by18aczt	111	37	be	be	VB
cord-023417-by18aczt	111	38	exclusively	exclusively	RB
cord-023417-by18aczt	111	39	expressed	express	VBN
cord-023417-by18aczt	111	40	on	on	IN
cord-023417-by18aczt	111	41	differentiated	differentiate	VBN
cord-023417-by18aczt	111	42	T1	t1	NN
cord-023417-by18aczt	111	43	cells	cell	NNS
cord-023417-by18aczt	111	44	,	,	,
cord-023417-by18aczt	111	45	was	be	VBD
cord-023417-by18aczt	111	46	not	not	RB
cord-023417-by18aczt	111	47	altered	alter	VBN
cord-023417-by18aczt	111	48	by	by	IN
cord-023417-by18aczt	111	49	DNA	dna	NN
cord-023417-by18aczt	111	50	vaccination	vaccination	NN
cord-023417-by18aczt	111	51	.	.	.
cord-023417-by18aczt	112	1	We	-PRON-	PRP
cord-023417-by18aczt	112	2	did	do	VBD
cord-023417-by18aczt	112	3	not	not	RB
cord-023417-by18aczt	112	4	note	note	VB
cord-023417-by18aczt	112	5	any	any	DT
cord-023417-by18aczt	112	6	clonal	clonal	JJ
cord-023417-by18aczt	112	7	deletion	deletion	NN
cord-023417-by18aczt	112	8	upon	upon	IN
cord-023417-by18aczt	112	9	tolerization	tolerization	NN
cord-023417-by18aczt	112	10	,	,	,
cord-023417-by18aczt	112	11	but	but	CC
cord-023417-by18aczt	112	12	detected	detect	VBD
cord-023417-by18aczt	112	13	an	an	DT
cord-023417-by18aczt	112	14	antigen	antigen	NN
cord-023417-by18aczt	112	15	-	-	HYPH
cord-023417-by18aczt	112	16	specific	specific	JJ
cord-023417-by18aczt	112	17	lymphocyte	lymphocyte	NN
cord-023417-by18aczt	112	18	population	population	NN
cord-023417-by18aczt	112	19	upregulating	upregulate	VBG
cord-023417-by18aczt	112	20	IFNg	IFNg	NNS
cord-023417-by18aczt	112	21	upon	upon	IN
cord-023417-by18aczt	112	22	recall	recall	NN
cord-023417-by18aczt	112	23	stimulation	stimulation	NN
cord-023417-by18aczt	112	24	3	3	CD
cord-023417-by18aczt	112	25	weeks	week	NNS
cord-023417-by18aczt	112	26	after	after	IN
cord-023417-by18aczt	112	27	protective	protective	JJ
cord-023417-by18aczt	112	28	DNA	dna	NN
cord-023417-by18aczt	112	29	vaccination	vaccination	NN
cord-023417-by18aczt	112	30	.	.	.
cord-023417-by18aczt	113	1	In	in	IN
cord-023417-by18aczt	113	2	protected	protect	VBN
cord-023417-by18aczt	113	3	rats	rat	NNS
cord-023417-by18aczt	113	4	,	,	,
cord-023417-by18aczt	113	5	we	-PRON-	PRP
cord-023417-by18aczt	113	6	observed	observe	VBD
cord-023417-by18aczt	113	7	(	(	-LRB-
cord-023417-by18aczt	113	8	1	1	LS
cord-023417-by18aczt	113	9	)	)	-RRB-
cord-023417-by18aczt	113	10	no	no	DT
cord-023417-by18aczt	113	11	alterations	alteration	NNS
cord-023417-by18aczt	113	12	in	in	IN
cord-023417-by18aczt	113	13	antigenspecific	antigenspecific	NN
cord-023417-by18aczt	113	14	Th2	th2	CD
cord-023417-by18aczt	113	15	or	or	CC
cord-023417-by18aczt	113	16	Th3	th3	JJ
cord-023417-by18aczt	113	17	responses	response	NNS
cord-023417-by18aczt	113	18	,	,	,
cord-023417-by18aczt	113	19	(	(	-LRB-
cord-023417-by18aczt	113	20	2	2	LS
cord-023417-by18aczt	113	21	)	)	-RRB-
cord-023417-by18aczt	113	22	reduced	reduce	VBN
cord-023417-by18aczt	113	23	MHC	MHC	NNP
cord-023417-by18aczt	113	24	II	II	NNP
cord-023417-by18aczt	113	25	expression	expression	NN
cord-023417-by18aczt	113	26	on	on	IN
cord-023417-by18aczt	113	27	splenocytes	splenocytes	NNP
cord-023417-by18aczt	113	28	early	early	RB
cord-023417-by18aczt	113	29	after	after	IN
cord-023417-by18aczt	113	30	EAE	EAE	NNP
cord-023417-by18aczt	113	31	induction	induction	NN
cord-023417-by18aczt	113	32	,	,	,
cord-023417-by18aczt	113	33	(	(	-LRB-
cord-023417-by18aczt	113	34	3	3	LS
cord-023417-by18aczt	113	35	)	)	-RRB-
cord-023417-by18aczt	113	36	antigen	antigen	NN
cord-023417-by18aczt	113	37	-	-	HYPH
cord-023417-by18aczt	113	38	specific	specific	JJ
cord-023417-by18aczt	113	39	upregulation	upregulation	NN
cord-023417-by18aczt	113	40	of	of	IN
cord-023417-by18aczt	113	41	IFNb	IFNb	NNS
cord-023417-by18aczt	113	42	upon	upon	IN
cord-023417-by18aczt	113	43	recall	recall	VBP
cord-023417-by18aczt	113	44	stimulation	stimulation	NN
cord-023417-by18aczt	113	45	and	and	CC
cord-023417-by18aczt	113	46	(	(	-LRB-
cord-023417-by18aczt	113	47	4	4	LS
cord-023417-by18aczt	113	48	)	)	-RRB-
cord-023417-by18aczt	113	49	reduced	reduce	VBN
cord-023417-by18aczt	113	50	IL-12Rb2	il-12rb2	NN
cord-023417-by18aczt	113	51	on	on	IN
cord-023417-by18aczt	113	52	lymphocytes	lymphocyte	NNS
cord-023417-by18aczt	113	53	.	.	.
cord-023417-by18aczt	114	1	We	-PRON-	PRP
cord-023417-by18aczt	114	2	thus	thus	RB
cord-023417-by18aczt	114	3	demonstrate	demonstrate	VBP
cord-023417-by18aczt	114	4	an	an	DT
cord-023417-by18aczt	114	5	association	association	NN
cord-023417-by18aczt	114	6	of	of	IN
cord-023417-by18aczt	114	7	the	the	DT
cord-023417-by18aczt	114	8	protective	protective	JJ
cord-023417-by18aczt	114	9	effect	effect	NN
cord-023417-by18aczt	114	10	of	of	IN
cord-023417-by18aczt	114	11	DNA	dna	NN
cord-023417-by18aczt	114	12	vaccination	vaccination	NN
cord-023417-by18aczt	114	13	with	with	IN
cord-023417-by18aczt	114	14	expression	expression	NN
cord-023417-by18aczt	114	15	of	of	IN
cord-023417-by18aczt	114	16	IFNb	IFNb	NNS
cord-023417-by18aczt	114	17	.	.	.
cord-023417-by18aczt	115	1	We	-PRON-	PRP
cord-023417-by18aczt	115	2	are	be	VBP
cord-023417-by18aczt	115	3	currently	currently	RB
cord-023417-by18aczt	115	4	investigating	investigate	VBG
cord-023417-by18aczt	115	5	the	the	DT
cord-023417-by18aczt	115	6	cellular	cellular	JJ
cord-023417-by18aczt	115	7	mechanisms	mechanism	NNS
cord-023417-by18aczt	115	8	behind	behind	IN
cord-023417-by18aczt	115	9	this	this	DT
cord-023417-by18aczt	115	10	IFNb	IFNb	NNS
cord-023417-by18aczt	115	11	-	-	HYPH
cord-023417-by18aczt	115	12	mediated	mediate	VBN
cord-023417-by18aczt	115	13	protection	protection	NN
cord-023417-by18aczt	115	14	.	.	.
cord-023417-by18aczt	116	1	Multiple	multiple	JJ
cord-023417-by18aczt	116	2	sclerosis	sclerosis	NN
cord-023417-by18aczt	116	3	(	(	-LRB-
cord-023417-by18aczt	116	4	MS	MS	NNP
cord-023417-by18aczt	116	5	)	)	-RRB-
cord-023417-by18aczt	116	6	is	be	VBZ
cord-023417-by18aczt	116	7	an	an	DT
cord-023417-by18aczt	116	8	autoimmune	autoimmune	JJ
cord-023417-by18aczt	116	9	condition	condition	NN
cord-023417-by18aczt	116	10	characterized	characterize	VBN
cord-023417-by18aczt	116	11	by	by	IN
cord-023417-by18aczt	116	12	degeneration	degeneration	NN
cord-023417-by18aczt	116	13	of	of	IN
cord-023417-by18aczt	116	14	nerve	nerve	NN
cord-023417-by18aczt	116	15	fibre	fibre	NN
cord-023417-by18aczt	116	16	myelin	myelin	NN
cord-023417-by18aczt	116	17	sheets	sheet	NNS
cord-023417-by18aczt	116	18	.	.	.
cord-023417-by18aczt	117	1	A	a	DT
cord-023417-by18aczt	117	2	candidate	candidate	NN
cord-023417-by18aczt	117	3	autoantigen	autoantigen	NN
cord-023417-by18aczt	117	4	,	,	,
cord-023417-by18aczt	117	5	myelin	myelin	JJ
cord-023417-by18aczt	117	6	basic	basic	JJ
cord-023417-by18aczt	117	7	protein	protein	NN
cord-023417-by18aczt	117	8	(	(	-LRB-
cord-023417-by18aczt	117	9	MBP	MBP	NNP
cord-023417-by18aczt	117	10	)	)	-RRB-
cord-023417-by18aczt	117	11	,	,	,
cord-023417-by18aczt	117	12	has	have	VBZ
cord-023417-by18aczt	117	13	especially	especially	RB
cord-023417-by18aczt	117	14	attracted	attract	VBN
cord-023417-by18aczt	117	15	attention	attention	NN
cord-023417-by18aczt	117	16	.	.	.
cord-023417-by18aczt	118	1	The	the	DT
cord-023417-by18aczt	118	2	presence	presence	NN
cord-023417-by18aczt	118	3	of	of	IN
cord-023417-by18aczt	118	4	anti	anti	JJ
cord-023417-by18aczt	118	5	-	-	JJ
cord-023417-by18aczt	118	6	MBP	mbp	JJ
cord-023417-by18aczt	118	7	antibodies	antibody	NNS
cord-023417-by18aczt	118	8	is	be	VBZ
cord-023417-by18aczt	118	9	a	a	DT
cord-023417-by18aczt	118	10	predictor	predictor	NN
cord-023417-by18aczt	118	11	of	of	IN
cord-023417-by18aczt	118	12	definite	definite	JJ
cord-023417-by18aczt	118	13	MS	MS	NNP
cord-023417-by18aczt	118	14	,	,	,
cord-023417-by18aczt	118	15	but	but	CC
cord-023417-by18aczt	118	16	their	-PRON-	PRP$
cord-023417-by18aczt	118	17	role	role	NN
cord-023417-by18aczt	118	18	in	in	IN
cord-023417-by18aczt	118	19	the	the	DT
cord-023417-by18aczt	118	20	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	118	21	remains	remain	VBZ
cord-023417-by18aczt	118	22	obscure	obscure	JJ
cord-023417-by18aczt	118	23	.	.	.
cord-023417-by18aczt	119	1	T	t	NN
cord-023417-by18aczt	119	2	cells	cell	NNS
cord-023417-by18aczt	119	3	have	have	VBP
cord-023417-by18aczt	119	4	long	long	RB
cord-023417-by18aczt	119	5	been	be	VBN
cord-023417-by18aczt	119	6	known	know	VBN
cord-023417-by18aczt	119	7	to	to	TO
cord-023417-by18aczt	119	8	play	play	VB
cord-023417-by18aczt	119	9	a	a	DT
cord-023417-by18aczt	119	10	pivotal	pivotal	JJ
cord-023417-by18aczt	119	11	role	role	NN
cord-023417-by18aczt	119	12	in	in	IN
cord-023417-by18aczt	119	13	the	the	DT
cord-023417-by18aczt	119	14	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	119	15	of	of	IN
cord-023417-by18aczt	119	16	MS	MS	NNP
cord-023417-by18aczt	119	17	.	.	.
cord-023417-by18aczt	120	1	Recently	recently	RB
cord-023417-by18aczt	120	2	,	,	,
cord-023417-by18aczt	120	3	an	an	DT
cord-023417-by18aczt	120	4	important	important	JJ
cord-023417-by18aczt	120	5	role	role	NN
cord-023417-by18aczt	120	6	for	for	IN
cord-023417-by18aczt	120	7	B	b	NN
cord-023417-by18aczt	120	8	cells	cell	NNS
cord-023417-by18aczt	120	9	as	as	IN
cord-023417-by18aczt	120	10	autoantigen	autoantigen	NN
cord-023417-by18aczt	120	11	-	-	HYPH
cord-023417-by18aczt	120	12	presenting	present	VBG
cord-023417-by18aczt	120	13	cells	cell	NNS
cord-023417-by18aczt	120	14	has	have	VBZ
cord-023417-by18aczt	120	15	been	be	VBN
cord-023417-by18aczt	120	16	demonstrated	demonstrate	VBN
cord-023417-by18aczt	120	17	in	in	IN
cord-023417-by18aczt	120	18	other	other	JJ
cord-023417-by18aczt	120	19	autoimmune	autoimmune	JJ
cord-023417-by18aczt	120	20	diseases	disease	NNS
cord-023417-by18aczt	120	21	,	,	,
cord-023417-by18aczt	120	22	including	include	VBG
cord-023417-by18aczt	120	23	rheumatoid	rheumatoid	NN
cord-023417-by18aczt	120	24	arthritis	arthritis	NN
cord-023417-by18aczt	120	25	and	and	CC
cord-023417-by18aczt	120	26	diabetes	diabetes	NN
cord-023417-by18aczt	120	27	.	.	.
cord-023417-by18aczt	121	1	The	the	DT
cord-023417-by18aczt	121	2	uptake	uptake	NN
cord-023417-by18aczt	121	3	of	of	IN
cord-023417-by18aczt	121	4	MBP	MBP	NNP
cord-023417-by18aczt	121	5	by	by	IN
cord-023417-by18aczt	121	6	B	b	NN
cord-023417-by18aczt	121	7	cells	cell	NNS
cord-023417-by18aczt	121	8	and	and	CC
cord-023417-by18aczt	121	9	the	the	DT
cord-023417-by18aczt	121	10	presentation	presentation	NN
cord-023417-by18aczt	121	11	of	of	IN
cord-023417-by18aczt	121	12	MBP	MBP	NNP
cord-023417-by18aczt	121	13	-	-	HYPH
cord-023417-by18aczt	121	14	derive	derive	VBP
cord-023417-by18aczt	121	15	peptides	peptide	NNS
cord-023417-by18aczt	121	16	to	to	IN
cord-023417-by18aczt	121	17	T	T	NNP
cord-023417-by18aczt	121	18	helper	helper	NN
cord-023417-by18aczt	121	19	(	(	-LRB-
cord-023417-by18aczt	121	20	Th	Th	NNP
cord-023417-by18aczt	121	21	)	)	-RRB-
cord-023417-by18aczt	121	22	cells	cell	NNS
cord-023417-by18aczt	121	23	by	by	IN
cord-023417-by18aczt	121	24	B	b	NN
cord-023417-by18aczt	121	25	cells	cell	NNS
cord-023417-by18aczt	121	26	may	may	MD
cord-023417-by18aczt	121	27	be	be	VB
cord-023417-by18aczt	121	28	promoted	promote	VBN
cord-023417-by18aczt	121	29	by	by	IN
cord-023417-by18aczt	121	30	the	the	DT
cord-023417-by18aczt	121	31	formation	formation	NN
cord-023417-by18aczt	121	32	of	of	IN
cord-023417-by18aczt	121	33	complement	complement	NN
cord-023417-by18aczt	121	34	(	(	-LRB-
cord-023417-by18aczt	121	35	C	c	NN
cord-023417-by18aczt	121	36	)	)	-RRB-
cord-023417-by18aczt	121	37	activating	activate	VBG
cord-023417-by18aczt	121	38	immune	immune	JJ
cord-023417-by18aczt	121	39	complexes	complex	NNS
cord-023417-by18aczt	121	40	(	(	-LRB-
cord-023417-by18aczt	121	41	ICs	ICs	NNP
cord-023417-by18aczt	121	42	)	)	-RRB-
cord-023417-by18aczt	121	43	between	between	IN
cord-023417-by18aczt	121	44	MBP	MBP	NNP
cord-023417-by18aczt	121	45	and	and	CC
cord-023417-by18aczt	121	46	natural	natural	JJ
cord-023417-by18aczt	121	47	autoantibodies	autoantibody	NNS
cord-023417-by18aczt	121	48	in	in	IN
cord-023417-by18aczt	121	49	healthy	healthy	JJ
cord-023417-by18aczt	121	50	individuals	individual	NNS
cord-023417-by18aczt	121	51	and	and	CC
cord-023417-by18aczt	121	52	disease	disease	NN
cord-023417-by18aczt	121	53	-	-	HYPH
cord-023417-by18aczt	121	54	associated	associate	VBN
cord-023417-by18aczt	121	55	anti	anti	JJ
cord-023417-by18aczt	121	56	-	-	JJ
cord-023417-by18aczt	121	57	MBP	mbp	JJ
cord-023417-by18aczt	121	58	antibodies	antibody	NNS
cord-023417-by18aczt	121	59	in	in	IN
cord-023417-by18aczt	121	60	MS	MS	NNP
cord-023417-by18aczt	121	61	patients	patient	NNS
cord-023417-by18aczt	121	62	,	,	,
cord-023417-by18aczt	121	63	respectively	respectively	RB
cord-023417-by18aczt	121	64	.	.	.
cord-023417-by18aczt	122	1	We	-PRON-	PRP
cord-023417-by18aczt	122	2	have	have	VBP
cord-023417-by18aczt	122	3	investigated	investigate	VBN
cord-023417-by18aczt	122	4	the	the	DT
cord-023417-by18aczt	122	5	formation	formation	NN
cord-023417-by18aczt	122	6	of	of	IN
cord-023417-by18aczt	122	7	MBP	MBP	NNP
cord-023417-by18aczt	122	8	-	-	HYPH
cord-023417-by18aczt	122	9	containing	contain	VBG
cord-023417-by18aczt	122	10	IC	IC	NNP
cord-023417-by18aczt	122	11	,	,	,
cord-023417-by18aczt	122	12	the	the	DT
cord-023417-by18aczt	122	13	binding	binding	NN
cord-023417-by18aczt	122	14	of	of	IN
cord-023417-by18aczt	122	15	MBP	MBP	NNP
cord-023417-by18aczt	122	16	to	to	IN
cord-023417-by18aczt	122	17	B	b	NN
cord-023417-by18aczt	122	18	cells	cell	NNS
cord-023417-by18aczt	122	19	,	,	,
cord-023417-by18aczt	122	20	the	the	DT
cord-023417-by18aczt	122	21	MBP	MBP	NNP
cord-023417-by18aczt	122	22	-	-	HYPH
cord-023417-by18aczt	122	23	elicited	elicit	VBN
cord-023417-by18aczt	122	24	induction	induction	NN
cord-023417-by18aczt	122	25	of	of	IN
cord-023417-by18aczt	122	26	Th	Th	NNP
cord-023417-by18aczt	122	27	-	-	HYPH
cord-023417-by18aczt	122	28	cell	cell	NN
cord-023417-by18aczt	122	29	and	and	CC
cord-023417-by18aczt	122	30	B	b	NN
cord-023417-by18aczt	122	31	-	-	HYPH
cord-023417-by18aczt	122	32	cell	cell	NN
cord-023417-by18aczt	122	33	proliferation	proliferation	NN
cord-023417-by18aczt	122	34	and	and	CC
cord-023417-by18aczt	122	35	the	the	DT
cord-023417-by18aczt	122	36	cytokine	cytokine	NN
cord-023417-by18aczt	122	37	production	production	NN
cord-023417-by18aczt	122	38	in	in	IN
cord-023417-by18aczt	122	39	peripheral	peripheral	JJ
cord-023417-by18aczt	122	40	blood	blood	NN
cord-023417-by18aczt	122	41	mononuclear	mononuclear	NN
cord-023417-by18aczt	122	42	cells	cell	NNS
cord-023417-by18aczt	122	43	(	(	-LRB-
cord-023417-by18aczt	122	44	PBMCs	pbmc	NNS
cord-023417-by18aczt	122	45	)	)	-RRB-
cord-023417-by18aczt	122	46	from	from	IN
cord-023417-by18aczt	122	47	healthy	healthy	JJ
cord-023417-by18aczt	122	48	donors	donor	NNS
cord-023417-by18aczt	122	49	grown	grow	VBN
cord-023417-by18aczt	122	50	in	in	IN
cord-023417-by18aczt	122	51	the	the	DT
cord-023417-by18aczt	122	52	presence	presence	NN
cord-023417-by18aczt	122	53	of	of	IN
cord-023417-by18aczt	122	54	intact	intact	JJ
cord-023417-by18aczt	122	55	or	or	CC
cord-023417-by18aczt	122	56	C	c	NN
cord-023417-by18aczt	122	57	-	-	HYPH
cord-023417-by18aczt	122	58	inactivated	inactivate	VBN
cord-023417-by18aczt	122	59	serum	serum	NN
cord-023417-by18aczt	122	60	from	from	IN
cord-023417-by18aczt	122	61	healthy	healthy	JJ
cord-023417-by18aczt	122	62	donors	donor	NNS
cord-023417-by18aczt	122	63	or	or	CC
cord-023417-by18aczt	122	64	patients	patient	NNS
cord-023417-by18aczt	122	65	with	with	IN
cord-023417-by18aczt	122	66	MS	MS	NNP
cord-023417-by18aczt	122	67	.	.	.
cord-023417-by18aczt	123	1	While	while	IN
cord-023417-by18aczt	123	2	MBP	MBP	NNP
cord-023417-by18aczt	123	3	did	do	VBD
cord-023417-by18aczt	123	4	not	not	RB
cord-023417-by18aczt	123	5	induce	induce	VB
cord-023417-by18aczt	123	6	measurable	measurable	JJ
cord-023417-by18aczt	123	7	proliferation	proliferation	NN
cord-023417-by18aczt	123	8	of	of	IN
cord-023417-by18aczt	123	9	B	b	NN
cord-023417-by18aczt	123	10	cells	cell	NNS
cord-023417-by18aczt	123	11	nor	nor	CC
cord-023417-by18aczt	123	12	CD4	CD4	NNP
cord-023417-by18aczt	123	13	þ	þ	NNP
cord-023417-by18aczt	123	14	T	t	NN
cord-023417-by18aczt	123	15	cells	cell	NNS
cord-023417-by18aczt	123	16	,	,	,
cord-023417-by18aczt	123	17	we	-PRON-	PRP
cord-023417-by18aczt	123	18	observed	observe	VBD
cord-023417-by18aczt	123	19	the	the	DT
cord-023417-by18aczt	123	20	production	production	NN
cord-023417-by18aczt	123	21	of	of	IN
cord-023417-by18aczt	123	22	TNF	TNF	NNP
cord-023417-by18aczt	123	23	-	-	HYPH
cord-023417-by18aczt	123	24	a	a	NNP
cord-023417-by18aczt	123	25	,	,	,
cord-023417-by18aczt	123	26	IFN	IFN	NNP
cord-023417-by18aczt	123	27	-	-	HYPH
cord-023417-by18aczt	123	28	g	g	NNP
cord-023417-by18aczt	123	29	and	and	CC
cord-023417-by18aczt	123	30	IL-10	IL-10	NNP
cord-023417-by18aczt	123	31	by	by	IN
cord-023417-by18aczt	123	32	PBMC	PBMC	NNP
cord-023417-by18aczt	123	33	in	in	IN
cord-023417-by18aczt	123	34	response	response	NN
cord-023417-by18aczt	123	35	to	to	IN
cord-023417-by18aczt	123	36	incubation	incubation	NN
cord-023417-by18aczt	123	37	with	with	IN
cord-023417-by18aczt	123	38	MBP	MBP	NNP
cord-023417-by18aczt	123	39	in	in	IN
cord-023417-by18aczt	123	40	the	the	DT
cord-023417-by18aczt	123	41	presence	presence	NN
cord-023417-by18aczt	123	42	of	of	IN
cord-023417-by18aczt	123	43	sera	sera	NNP
cord-023417-by18aczt	123	44	from	from	IN
cord-023417-by18aczt	123	45	healthy	healthy	JJ
cord-023417-by18aczt	123	46	controls	control	NNS
cord-023417-by18aczt	123	47	as	as	RB
cord-023417-by18aczt	123	48	well	well	RB
cord-023417-by18aczt	123	49	as	as	IN
cord-023417-by18aczt	123	50	sera	sera	NNP
cord-023417-by18aczt	123	51	from	from	IN
cord-023417-by18aczt	123	52	MS	MS	NNP
cord-023417-by18aczt	123	53	patients	patient	NNS
cord-023417-by18aczt	123	54	.	.	.
cord-023417-by18aczt	124	1	By	by	IN
cord-023417-by18aczt	124	2	contrast	contrast	NN
cord-023417-by18aczt	124	3	,	,	,
cord-023417-by18aczt	124	4	no	no	DT
cord-023417-by18aczt	124	5	production	production	NN
cord-023417-by18aczt	124	6	of	of	IN
cord-023417-by18aczt	124	7	IL-2	IL-2	NNP
cord-023417-by18aczt	124	8	,	,	,
cord-023417-by18aczt	124	9	IL-4	IL-4	NNP
cord-023417-by18aczt	124	10	and	and	CC
cord-023417-by18aczt	124	11	IL-5	IL-5	NNP
cord-023417-by18aczt	124	12	was	be	VBD
cord-023417-by18aczt	124	13	detected	detect	VBN
cord-023417-by18aczt	124	14	.	.	.
cord-023417-by18aczt	125	1	We	-PRON-	PRP
cord-023417-by18aczt	125	2	are	be	VBP
cord-023417-by18aczt	125	3	currently	currently	RB
cord-023417-by18aczt	125	4	investigating	investigate	VBG
cord-023417-by18aczt	125	5	the	the	DT
cord-023417-by18aczt	125	6	capability	capability	NN
cord-023417-by18aczt	125	7	of	of	IN
cord-023417-by18aczt	125	8	MS	MS	NNP
cord-023417-by18aczt	125	9	sera	sera	NNP
cord-023417-by18aczt	125	10	to	to	TO
cord-023417-by18aczt	125	11	promote	promote	VB
cord-023417-by18aczt	125	12	the	the	DT
cord-023417-by18aczt	125	13	formation	formation	NN
cord-023417-by18aczt	125	14	of	of	IN
cord-023417-by18aczt	125	15	MBP	MBP	NNP
cord-023417-by18aczt	125	16	-	-	HYPH
cord-023417-by18aczt	125	17	containing	contain	VBG
cord-023417-by18aczt	125	18	IC	IC	NNP
cord-023417-by18aczt	125	19	and	and	CC
cord-023417-by18aczt	125	20	thereby	thereby	RB
cord-023417-by18aczt	125	21	enhance	enhance	VB
cord-023417-by18aczt	125	22	the	the	DT
cord-023417-by18aczt	125	23	cytokine	cytokine	NN
cord-023417-by18aczt	125	24	responses	response	NNS
cord-023417-by18aczt	125	25	,	,	,
cord-023417-by18aczt	125	26	by	by	IN
cord-023417-by18aczt	125	27	virtue	virtue	NN
cord-023417-by18aczt	125	28	of	of	IN
cord-023417-by18aczt	125	29	elevated	elevated	JJ
cord-023417-by18aczt	125	30	anti	anti	JJ
cord-023417-by18aczt	125	31	-	-	JJ
cord-023417-by18aczt	125	32	MBP	mbp	JJ
cord-023417-by18aczt	125	33	contents	content	NNS
cord-023417-by18aczt	125	34	.	.	.
cord-023417-by18aczt	126	1	The	the	DT
cord-023417-by18aczt	126	2	phagolysosomally	phagolysosomally	RB
cord-023417-by18aczt	126	3	localized	localized	JJ
cord-023417-by18aczt	126	4	acid	acid	NN
cord-023417-by18aczt	126	5	sphingomyelinase	sphingomyelinase	NN
cord-023417-by18aczt	126	6	(	(	-LRB-
cord-023417-by18aczt	126	7	ASMase	ASMase	NNP
cord-023417-by18aczt	126	8	)	)	-RRB-
cord-023417-by18aczt	127	1	activated	activate	VBN
cord-023417-by18aczt	127	2	by	by	IN
cord-023417-by18aczt	127	3	proinflammatory	proinflammatory	JJ
cord-023417-by18aczt	127	4	cytokines	cytokine	NNS
cord-023417-by18aczt	127	5	such	such	JJ
cord-023417-by18aczt	127	6	as	as	IN
cord-023417-by18aczt	127	7	TNF	TNF	NNP
cord-023417-by18aczt	127	8	and	and	CC
cord-023417-by18aczt	127	9	IFN	IFN	NNP
cord-023417-by18aczt	127	10	-	-	HYPH
cord-023417-by18aczt	127	11	g	g	NNP
cord-023417-by18aczt	128	1	generates	generate	VBZ
cord-023417-by18aczt	128	2	the	the	DT
cord-023417-by18aczt	128	3	signalling	signal	VBG
cord-023417-by18aczt	128	4	molecule	molecule	NN
cord-023417-by18aczt	128	5	ceramide	ceramide	NN
cord-023417-by18aczt	128	6	which	which	WDT
cord-023417-by18aczt	128	7	in	in	IN
cord-023417-by18aczt	128	8	turn	turn	NN
cord-023417-by18aczt	128	9	results	result	VBZ
cord-023417-by18aczt	128	10	in	in	IN
cord-023417-by18aczt	128	11	the	the	DT
cord-023417-by18aczt	128	12	activation	activation	NN
cord-023417-by18aczt	128	13	of	of	IN
cord-023417-by18aczt	128	14	proteases	protease	NNS
cord-023417-by18aczt	128	15	like	like	IN
cord-023417-by18aczt	129	1	cathepsin	cathepsin	NNP
cord-023417-by18aczt	129	2	D.	D.	NNP
cord-023417-by18aczt	129	3	These	these	DT
cord-023417-by18aczt	129	4	characteristics	characteristic	NNS
cord-023417-by18aczt	129	5	of	of	IN
cord-023417-by18aczt	129	6	ASMase	ASMase	NNP
cord-023417-by18aczt	129	7	suggest	suggest	VBP
cord-023417-by18aczt	129	8	a	a	DT
cord-023417-by18aczt	129	9	possible	possible	JJ
cord-023417-by18aczt	129	10	role	role	NN
cord-023417-by18aczt	129	11	of	of	IN
cord-023417-by18aczt	129	12	this	this	DT
cord-023417-by18aczt	129	13	molecule	molecule	NN
cord-023417-by18aczt	129	14	in	in	IN
cord-023417-by18aczt	129	15	the	the	DT
cord-023417-by18aczt	129	16	phagocytotic	phagocytotic	JJ
cord-023417-by18aczt	129	17	uptake	uptake	NN
cord-023417-by18aczt	129	18	and	and	CC
cord-023417-by18aczt	129	19	phagosomal	phagosomal	NN
cord-023417-by18aczt	129	20	degradation	degradation	NN
cord-023417-by18aczt	129	21	processes	process	NNS
cord-023417-by18aczt	129	22	of	of	IN
cord-023417-by18aczt	129	23	antigens	antigen	NNS
cord-023417-by18aczt	129	24	or	or	CC
cord-023417-by18aczt	129	25	in	in	IN
cord-023417-by18aczt	129	26	antigen	antigen	NN
cord-023417-by18aczt	129	27	presentation	presentation	NN
cord-023417-by18aczt	129	28	.	.	.
cord-023417-by18aczt	130	1	We	-PRON-	PRP
cord-023417-by18aczt	130	2	show	show	VBP
cord-023417-by18aczt	130	3	here	here	RB
cord-023417-by18aczt	130	4	that	that	IN
cord-023417-by18aczt	130	5	ASMase	asmase	NN
cord-023417-by18aczt	130	6	-/mice	-/mice	NN
cord-023417-by18aczt	130	7	fail	fail	VB
cord-023417-by18aczt	130	8	to	to	TO
cord-023417-by18aczt	130	9	eliminate	eliminate	VB
cord-023417-by18aczt	130	10	the	the	DT
cord-023417-by18aczt	130	11	noncytopathic	noncytopathic	JJ
cord-023417-by18aczt	130	12	lymphocytic	lymphocytic	JJ
cord-023417-by18aczt	130	13	choriomeningitis	choriomeningitis	NNP
cord-023417-by18aczt	130	14	(	(	-LRB-
cord-023417-by18aczt	130	15	LCM	LCM	NNP
cord-023417-by18aczt	130	16	)	)	-RRB-
cord-023417-by18aczt	130	17	virus	virus	NN
cord-023417-by18aczt	130	18	as	as	RB
cord-023417-by18aczt	130	19	rapidly	rapidly	RB
cord-023417-by18aczt	130	20	as	as	IN
cord-023417-by18aczt	130	21	littermate	littermate	NN
cord-023417-by18aczt	130	22	wildtype	wildtype	NN
cord-023417-by18aczt	130	23	mice	mouse	NNS
cord-023417-by18aczt	130	24	.	.	.
cord-023417-by18aczt	131	1	Investigation	investigation	NN
cord-023417-by18aczt	131	2	of	of	IN
cord-023417-by18aczt	131	3	the	the	DT
cord-023417-by18aczt	131	4	immune	immune	JJ
cord-023417-by18aczt	131	5	response	response	NN
cord-023417-by18aczt	131	6	revealed	reveal	VBD
cord-023417-by18aczt	131	7	a	a	DT
cord-023417-by18aczt	131	8	reduced	reduce	VBN
cord-023417-by18aczt	131	9	expansion	expansion	NN
cord-023417-by18aczt	131	10	of	of	IN
cord-023417-by18aczt	131	11	CD8	CD8	NNP
cord-023417-by18aczt	131	12	þ	þ	NNP
cord-023417-by18aczt	131	13	T	T	NNP
cord-023417-by18aczt	131	14	cells	cell	NNS
cord-023417-by18aczt	131	15	.	.	.
cord-023417-by18aczt	132	1	The	the	DT
cord-023417-by18aczt	132	2	secretion	secretion	NN
cord-023417-by18aczt	132	3	of	of	IN
cord-023417-by18aczt	132	4	IFN	IFN	NNP
cord-023417-by18aczt	132	5	-	-	HYPH
cord-023417-by18aczt	132	6	g	g	NNP
cord-023417-by18aczt	132	7	in	in	IN
cord-023417-by18aczt	132	8	response	response	NN
cord-023417-by18aczt	132	9	to	to	TO
cord-023417-by18aczt	132	10	contact	contact	VB
cord-023417-by18aczt	132	11	with	with	IN
cord-023417-by18aczt	132	12	target	target	NN
cord-023417-by18aczt	132	13	cells	cell	NNS
cord-023417-by18aczt	132	14	as	as	RB
cord-023417-by18aczt	132	15	well	well	RB
cord-023417-by18aczt	132	16	as	as	IN
cord-023417-by18aczt	132	17	the	the	DT
cord-023417-by18aczt	132	18	cytolytic	cytolytic	JJ
cord-023417-by18aczt	132	19	activity	activity	NN
cord-023417-by18aczt	132	20	of	of	IN
cord-023417-by18aczt	132	21	virus	virus	NN
cord-023417-by18aczt	132	22	-	-	HYPH
cord-023417-by18aczt	132	23	specific	specific	JJ
cord-023417-by18aczt	132	24	CD8	CD8	NNP
cord-023417-by18aczt	132	25	þ	þ	NNP
cord-023417-by18aczt	132	26	T	t	NN
cord-023417-by18aczt	132	27	cells	cell	NNS
cord-023417-by18aczt	132	28	was	be	VBD
cord-023417-by18aczt	132	29	severely	severely	RB
cord-023417-by18aczt	132	30	impaired	impaired	JJ
cord-023417-by18aczt	132	31	.	.	.
cord-023417-by18aczt	133	1	Additionally	additionally	RB
cord-023417-by18aczt	133	2	,	,	,
cord-023417-by18aczt	133	3	both	both	DT
cord-023417-by18aczt	133	4	phases	phase	NNS
cord-023417-by18aczt	133	5	of	of	IN
cord-023417-by18aczt	133	6	the	the	DT
cord-023417-by18aczt	133	7	LCM	LCM	NNP
cord-023417-by18aczt	133	8	virus	virus	NN
cord-023417-by18aczt	133	9	-	-	HYPH
cord-023417-by18aczt	133	10	specific	specific	JJ
cord-023417-by18aczt	133	11	DTH	DTH	NNP
cord-023417-by18aczt	133	12	response	response	NN
cord-023417-by18aczt	133	13	,	,	,
cord-023417-by18aczt	133	14	mediated	mediate	VBN
cord-023417-by18aczt	133	15	by	by	IN
cord-023417-by18aczt	133	16	CD8	CD8	NNP
cord-023417-by18aczt	133	17	þ	þ	NNP
cord-023417-by18aczt	133	18	and	and	CC
cord-023417-by18aczt	133	19	CD4	CD4	NNP
cord-023417-by18aczt	133	20	þ	þ	NNP
cord-023417-by18aczt	133	21	T	t	NN
cord-023417-by18aczt	133	22	cells	cell	NNS
cord-023417-by18aczt	133	23	consecutively	consecutively	RB
cord-023417-by18aczt	133	24	,	,	,
cord-023417-by18aczt	133	25	were	be	VBD
cord-023417-by18aczt	133	26	diminished	diminish	VBN
cord-023417-by18aczt	133	27	in	in	IN
cord-023417-by18aczt	133	28	ASMase	ASMase	NNP
cord-023417-by18aczt	133	29	-/mice	-/mice	NN
cord-023417-by18aczt	133	30	.	.	.
cord-023417-by18aczt	134	1	However	however	RB
cord-023417-by18aczt	134	2	,	,	,
cord-023417-by18aczt	134	3	the	the	DT
cord-023417-by18aczt	134	4	secondary	secondary	JJ
cord-023417-by18aczt	134	5	memory	memory	NN
cord-023417-by18aczt	134	6	response	response	NN
cord-023417-by18aczt	134	7	of	of	IN
cord-023417-by18aczt	134	8	virus	virus	NN
cord-023417-by18aczt	134	9	-	-	HYPH
cord-023417-by18aczt	134	10	specific	specific	JJ
cord-023417-by18aczt	134	11	CTL	CTL	NNP
cord-023417-by18aczt	134	12	was	be	VBD
cord-023417-by18aczt	134	13	not	not	RB
cord-023417-by18aczt	134	14	altered	alter	VBN
cord-023417-by18aczt	134	15	,	,	,
cord-023417-by18aczt	134	16	and	and	CC
cord-023417-by18aczt	134	17	the	the	DT
cord-023417-by18aczt	134	18	614	614	CD
cord-023417-by18aczt	134	19	Abstracts	abstract	NNS
cord-023417-by18aczt	134	20	.................................................................................................................................................................................................	.................................................................................................................................................................................................	.
cord-023417-by18aczt	135	1	virus	virus	NN
cord-023417-by18aczt	135	2	was	be	VBD
cord-023417-by18aczt	135	3	effectively	effectively	RB
cord-023417-by18aczt	135	4	controlled	control	VBN
cord-023417-by18aczt	135	5	for	for	IN
cord-023417-by18aczt	135	6	at	at	RB
cord-023417-by18aczt	135	7	least	least	JJS
cord-023417-by18aczt	135	8	3	3	CD
cord-023417-by18aczt	135	9	months	month	NNS
cord-023417-by18aczt	135	10	by	by	IN
cord-023417-by18aczt	135	11	ASMase	ASMase	NNP
cord-023417-by18aczt	135	12	-/mice	-/mice	NN
cord-023417-by18aczt	135	13	.	.	.
cord-023417-by18aczt	136	1	In	in	IN
cord-023417-by18aczt	136	2	conclusion	conclusion	NN
cord-023417-by18aczt	136	3	,	,	,
cord-023417-by18aczt	136	4	the	the	DT
cord-023417-by18aczt	136	5	results	result	NNS
cord-023417-by18aczt	136	6	of	of	IN
cord-023417-by18aczt	136	7	this	this	DT
cord-023417-by18aczt	136	8	study	study	NN
cord-023417-by18aczt	136	9	suggest	suggest	VBP
cord-023417-by18aczt	136	10	an	an	DT
cord-023417-by18aczt	136	11	involvement	involvement	NN
cord-023417-by18aczt	136	12	of	of	IN
cord-023417-by18aczt	136	13	the	the	DT
cord-023417-by18aczt	136	14	ASMase	asmase	NN
cord-023417-by18aczt	136	15	in	in	IN
cord-023417-by18aczt	136	16	the	the	DT
cord-023417-by18aczt	136	17	activation	activation	NN
cord-023417-by18aczt	136	18	,	,	,
cord-023417-by18aczt	136	19	expansion	expansion	NN
cord-023417-by18aczt	136	20	or	or	CC
cord-023417-by18aczt	136	21	maturation	maturation	NN
cord-023417-by18aczt	136	22	of	of	IN
cord-023417-by18aczt	136	23	virus	virus	NN
cord-023417-by18aczt	136	24	-	-	HYPH
cord-023417-by18aczt	136	25	specific	specific	JJ
cord-023417-by18aczt	136	26	CD8	CD8	NNP
cord-023417-by18aczt	136	27	þ	þ	NNP
cord-023417-by18aczt	136	28	T	t	NN
cord-023417-by18aczt	136	29	cells	cell	NNS
cord-023417-by18aczt	136	30	during	during	IN
cord-023417-by18aczt	136	31	the	the	DT
cord-023417-by18aczt	136	32	acute	acute	JJ
cord-023417-by18aczt	136	33	infection	infection	NN
cord-023417-by18aczt	136	34	of	of	IN
cord-023417-by18aczt	136	35	mice	mouse	NNS
cord-023417-by18aczt	136	36	with	with	IN
cord-023417-by18aczt	136	37	the	the	DT
cord-023417-by18aczt	136	38	LCM	LCM	NNP
cord-023417-by18aczt	136	39	virus	virus	NN
cord-023417-by18aczt	136	40	.	.	.
cord-023417-by18aczt	137	1	Novel	Novel	NNP
cord-023417-by18aczt	137	2	Markers	Markers	NNPS
cord-023417-by18aczt	137	3	for	for	IN
cord-023417-by18aczt	137	4	Alternative	Alternative	NNP
cord-023417-by18aczt	137	5	Activation	Activation	NNP
cord-023417-by18aczt	137	6	of	of	IN
cord-023417-by18aczt	137	7	Macrophages	Macrophages	NNPS
cord-023417-by18aczt	137	8	:	:	:
cord-023417-by18aczt	137	9	Macrophage	Macrophage	NNP
cord-023417-by18aczt	137	10	Galactose	Galactose	NNP
cord-023417-by18aczt	137	11	-	-	HYPH
cord-023417-by18aczt	137	12	Type	Type	NNP
cord-023417-by18aczt	137	13	C	c	NN
cord-023417-by18aczt	137	14	-	-	HYPH
cord-023417-by18aczt	137	15	Type	Type	NNP
cord-023417-by18aczt	137	16	Lectins	Lectins	NNP
cord-023417-by18aczt	137	17	1	1	CD
cord-023417-by18aczt	137	18	and	and	CC
cord-023417-by18aczt	137	19	2	2	CD
cord-023417-by18aczt	138	1	In	in	IN
cord-023417-by18aczt	138	2	parallel	parallel	NN
cord-023417-by18aczt	138	3	with	with	IN
cord-023417-by18aczt	138	4	the	the	DT
cord-023417-by18aczt	138	5	Th1	th1	CD
cord-023417-by18aczt	138	6	/	/	SYM
cord-023417-by18aczt	138	7	Th2	th2	CD
cord-023417-by18aczt	138	8	dichotomy	dichotomy	NN
cord-023417-by18aczt	138	9	,	,	,
cord-023417-by18aczt	138	10	macrophages	macrophage	NNS
cord-023417-by18aczt	138	11	are	be	VBP
cord-023417-by18aczt	138	12	capable	capable	JJ
cord-023417-by18aczt	138	13	of	of	IN
cord-023417-by18aczt	138	14	developing	develop	VBG
cord-023417-by18aczt	138	15	into	into	IN
cord-023417-by18aczt	138	16	functionally	functionally	RB
cord-023417-by18aczt	138	17	and	and	CC
cord-023417-by18aczt	138	18	molecularly	molecularly	RB
cord-023417-by18aczt	138	19	distinct	distinct	JJ
cord-023417-by18aczt	138	20	subpopulations	subpopulation	NNS
cord-023417-by18aczt	138	21	,	,	,
cord-023417-by18aczt	138	22	due	due	IN
cord-023417-by18aczt	138	23	to	to	IN
cord-023417-by18aczt	138	24	differences	difference	NNS
cord-023417-by18aczt	138	25	in	in	IN
cord-023417-by18aczt	138	26	,	,	,
cord-023417-by18aczt	138	27	for	for	IN
cord-023417-by18aczt	138	28	example	example	NN
cord-023417-by18aczt	138	29	cytokine	cytokine	NN
cord-023417-by18aczt	138	30	environment	environment	NN
cord-023417-by18aczt	138	31	and	and	CC
cord-023417-by18aczt	138	32	pathological	pathological	JJ
cord-023417-by18aczt	138	33	conditions	condition	NNS
cord-023417-by18aczt	138	34	.	.	.
cord-023417-by18aczt	139	1	While	while	IN
cord-023417-by18aczt	139	2	the	the	DT
cord-023417-by18aczt	139	3	best	well	RBS
cord-023417-by18aczt	139	4	-	-	HYPH
cord-023417-by18aczt	139	5	studied	study	VBN
cord-023417-by18aczt	139	6	,	,	,
cord-023417-by18aczt	139	7	classically	classically	RB
cord-023417-by18aczt	139	8	activated	activate	VBN
cord-023417-by18aczt	139	9	macrophage	macrophage	NN
cord-023417-by18aczt	139	10	is	be	VBZ
cord-023417-by18aczt	139	11	induced	induce	VBN
cord-023417-by18aczt	139	12	by	by	IN
cord-023417-by18aczt	139	13	type	type	NN
cord-023417-by18aczt	140	1	I	-PRON-	PRP
cord-023417-by18aczt	140	2	stimuli	stimulus	NNS
cord-023417-by18aczt	140	3	such	such	JJ
cord-023417-by18aczt	140	4	as	as	IN
cord-023417-by18aczt	140	5	IFN	IFN	NNP
cord-023417-by18aczt	140	6	-	-	HYPH
cord-023417-by18aczt	140	7	g	g	NNP
cord-023417-by18aczt	140	8	,	,	,
cord-023417-by18aczt	141	1	a	a	DT
cord-023417-by18aczt	141	2	type	type	NN
cord-023417-by18aczt	141	3	II	II	NNP
cord-023417-by18aczt	141	4	cytokine	cytokine	NN
cord-023417-by18aczt	141	5	environment	environment	NN
cord-023417-by18aczt	141	6	antagonizes	antagonize	VBZ
cord-023417-by18aczt	141	7	the	the	DT
cord-023417-by18aczt	141	8	classical	classical	JJ
cord-023417-by18aczt	141	9	activation	activation	NN
cord-023417-by18aczt	141	10	of	of	IN
cord-023417-by18aczt	141	11	macrophages	macrophage	NNS
cord-023417-by18aczt	141	12	and	and	CC
cord-023417-by18aczt	141	13	is	be	VBZ
cord-023417-by18aczt	141	14	capable	capable	JJ
cord-023417-by18aczt	141	15	of	of	IN
cord-023417-by18aczt	141	16	alternatively	alternatively	RB
cord-023417-by18aczt	141	17	activating	activate	VBG
cord-023417-by18aczt	141	18	macrophages	macrophage	NNS
cord-023417-by18aczt	141	19	.	.	.
cord-023417-by18aczt	142	1	However	however	RB
cord-023417-by18aczt	142	2	,	,	,
cord-023417-by18aczt	142	3	molecular	molecular	JJ
cord-023417-by18aczt	142	4	markers	marker	NNS
cord-023417-by18aczt	142	5	associated	associate	VBN
cord-023417-by18aczt	142	6	with	with	IN
cord-023417-by18aczt	142	7	these	these	DT
cord-023417-by18aczt	142	8	type	type	NN
cord-023417-by18aczt	142	9	II	ii	CD
cord-023417-by18aczt	142	10	cytokine	cytokine	NN
cord-023417-by18aczt	142	11	-	-	HYPH
cord-023417-by18aczt	142	12	dependent	dependent	JJ
cord-023417-by18aczt	142	13	,	,	,
cord-023417-by18aczt	142	14	alternatively	alternatively	RB
cord-023417-by18aczt	142	15	activated	activate	VBN
cord-023417-by18aczt	142	16	macrophages	macrophage	NNS
cord-023417-by18aczt	142	17	remain	remain	VBP
cord-023417-by18aczt	142	18	scarce	scarce	JJ
cord-023417-by18aczt	142	19	.	.	.
cord-023417-by18aczt	143	1	Besides	besides	IN
cord-023417-by18aczt	143	2	the	the	DT
cord-023417-by18aczt	143	3	earlier	early	RBR
cord-023417-by18aczt	143	4	documented	document	VBN
cord-023417-by18aczt	143	5	markers	marker	NNS
cord-023417-by18aczt	143	6	macrophage	macrophage	NN
cord-023417-by18aczt	143	7	mannose	mannose	NN
cord-023417-by18aczt	143	8	receptor	receptor	NN
cord-023417-by18aczt	143	9	and	and	CC
cord-023417-by18aczt	143	10	arginase	arginase	NNP
cord-023417-by18aczt	143	11	1	1	CD
cord-023417-by18aczt	143	12	,	,	,
cord-023417-by18aczt	143	13	we	-PRON-	PRP
cord-023417-by18aczt	143	14	recently	recently	RB
cord-023417-by18aczt	143	15	demonstrated	demonstrate	VBD
cord-023417-by18aczt	143	16	that	that	IN
cord-023417-by18aczt	143	17	murine	murine	NN
cord-023417-by18aczt	143	18	alternatively	alternatively	RB
cord-023417-by18aczt	143	19	activated	activate	VBN
cord-023417-by18aczt	143	20	macrophages	macrophage	NNS
cord-023417-by18aczt	143	21	are	be	VBP
cord-023417-by18aczt	143	22	characterized	characterize	VBN
cord-023417-by18aczt	143	23	by	by	IN
cord-023417-by18aczt	143	24	increased	increase	VBN
cord-023417-by18aczt	143	25	expression	expression	NN
cord-023417-by18aczt	143	26	of	of	IN
cord-023417-by18aczt	143	27	FIZZ1	FIZZ1	NNP
cord-023417-by18aczt	143	28	and	and	CC
cord-023417-by18aczt	143	29	Ym	Ym	NNP
cord-023417-by18aczt	143	30	.	.	.
cord-023417-by18aczt	144	1	We	-PRON-	PRP
cord-023417-by18aczt	144	2	now	now	RB
cord-023417-by18aczt	144	3	report	report	VBP
cord-023417-by18aczt	144	4	that	that	DT
cord-023417-by18aczt	144	5	expression	expression	NN
cord-023417-by18aczt	144	6	of	of	IN
cord-023417-by18aczt	144	7	the	the	DT
cord-023417-by18aczt	144	8	two	two	CD
cord-023417-by18aczt	144	9	members	member	NNS
cord-023417-by18aczt	144	10	of	of	IN
cord-023417-by18aczt	144	11	the	the	DT
cord-023417-by18aczt	144	12	mouse	mouse	NN
cord-023417-by18aczt	144	13	macrophage	macrophage	NN
cord-023417-by18aczt	144	14	galactose	galactose	NN
cord-023417-by18aczt	144	15	-	-	HYPH
cord-023417-by18aczt	144	16	type	type	NN
cord-023417-by18aczt	144	17	C	c	NN
cord-023417-by18aczt	144	18	-	-	HYPH
cord-023417-by18aczt	144	19	type	type	NN
cord-023417-by18aczt	144	20	lectin	lectin	NN
cord-023417-by18aczt	144	21	gene	gene	NN
cord-023417-by18aczt	144	22	family	family	NN
cord-023417-by18aczt	144	23	,	,	,
cord-023417-by18aczt	144	24	termed	term	VBN
cord-023417-by18aczt	144	25	mMGL1	mmgl1	NN
cord-023417-by18aczt	144	26	and	and	CC
cord-023417-by18aczt	144	27	mMGL2	mmgl2	NN
cord-023417-by18aczt	144	28	,	,	,
cord-023417-by18aczt	144	29	is	be	VBZ
cord-023417-by18aczt	144	30	induced	induce	VBN
cord-023417-by18aczt	144	31	in	in	IN
cord-023417-by18aczt	144	32	diverse	diverse	JJ
cord-023417-by18aczt	144	33	populations	population	NNS
cord-023417-by18aczt	144	34	of	of	IN
cord-023417-by18aczt	144	35	alternatively	alternatively	RB
cord-023417-by18aczt	144	36	activated	activate	VBN
cord-023417-by18aczt	144	37	macrophages	macrophage	NNS
cord-023417-by18aczt	144	38	,	,	,
cord-023417-by18aczt	144	39	including	include	VBG
cord-023417-by18aczt	144	40	peritoneal	peritoneal	JJ
cord-023417-by18aczt	144	41	macrophages	macrophage	NNS
cord-023417-by18aczt	144	42	elicited	elicit	VBN
cord-023417-by18aczt	144	43	during	during	IN
cord-023417-by18aczt	144	44	infection	infection	NN
cord-023417-by18aczt	144	45	with	with	IN
cord-023417-by18aczt	144	46	the	the	DT
cord-023417-by18aczt	144	47	protozoan	protozoan	NN
cord-023417-by18aczt	144	48	Trypanosoma	Trypanosoma	NNP
cord-023417-by18aczt	144	49	brucei	brucei	NNP
cord-023417-by18aczt	144	50	or	or	CC
cord-023417-by18aczt	144	51	the	the	DT
cord-023417-by18aczt	144	52	Helminth	Helminth	NNP
cord-023417-by18aczt	144	53	Taenia	Taenia	NNP
cord-023417-by18aczt	144	54	crassiceps	crassiceps	NN
cord-023417-by18aczt	144	55	,	,	,
cord-023417-by18aczt	144	56	and	and	CC
cord-023417-by18aczt	144	57	alveolar	alveolar	NN
cord-023417-by18aczt	144	58	macrophages	macrophage	NNS
cord-023417-by18aczt	144	59	elicited	elicit	VBN
cord-023417-by18aczt	144	60	in	in	IN
cord-023417-by18aczt	144	61	a	a	DT
cord-023417-by18aczt	144	62	mouse	mouse	NN
cord-023417-by18aczt	144	63	model	model	NN
cord-023417-by18aczt	144	64	of	of	IN
cord-023417-by18aczt	144	65	allergic	allergic	JJ
cord-023417-by18aczt	144	66	asthma	asthma	NN
cord-023417-by18aczt	144	67	.	.	.
cord-023417-by18aczt	145	1	We	-PRON-	PRP
cord-023417-by18aczt	145	2	also	also	RB
cord-023417-by18aczt	145	3	demonstrate	demonstrate	VBP
cord-023417-by18aczt	145	4	that	that	IN
cord-023417-by18aczt	145	5	,	,	,
cord-023417-by18aczt	145	6	in	in	IN
cord-023417-by18aczt	145	7	vitro	vitro	FW
cord-023417-by18aczt	145	8	,	,	,
cord-023417-by18aczt	145	9	interleukin-4	interleukin-4	NNP
cord-023417-by18aczt	145	10	and	and	CC
cord-023417-by18aczt	145	11	interleukin-13	interleukin-13	NN
cord-023417-by18aczt	145	12	upregulate	upregulate	VBP
cord-023417-by18aczt	145	13	mMGL1	mmgl1	NN
cord-023417-by18aczt	145	14	and	and	CC
cord-023417-by18aczt	145	15	mMGL2	mmgl2	NN
cord-023417-by18aczt	145	16	expression	expression	NN
cord-023417-by18aczt	145	17	and	and	CC
cord-023417-by18aczt	145	18	that	that	IN
cord-023417-by18aczt	145	19	,	,	,
cord-023417-by18aczt	145	20	in	in	IN
cord-023417-by18aczt	145	21	vivo	vivo	NN
cord-023417-by18aczt	145	22	,	,	,
cord-023417-by18aczt	145	23	induction	induction	NN
cord-023417-by18aczt	145	24	of	of	IN
cord-023417-by18aczt	145	25	mMGL1	mmgl1	NN
cord-023417-by18aczt	146	1	and	and	CC
cord-023417-by18aczt	146	2	mMGL2	mmgl2	NN
cord-023417-by18aczt	146	3	is	be	VBZ
cord-023417-by18aczt	146	4	dependent	dependent	JJ
cord-023417-by18aczt	146	5	on	on	IN
cord-023417-by18aczt	146	6	interleukin-4	interleukin-4	NNP
cord-023417-by18aczt	146	7	receptor	receptor	NN
cord-023417-by18aczt	146	8	signalling	signalling	NN
cord-023417-by18aczt	146	9	.	.	.
cord-023417-by18aczt	147	1	Moreover	moreover	RB
cord-023417-by18aczt	147	2	,	,	,
cord-023417-by18aczt	147	3	we	-PRON-	PRP
cord-023417-by18aczt	147	4	show	show	VBP
cord-023417-by18aczt	147	5	that	that	IN
cord-023417-by18aczt	147	6	regulation	regulation	NN
cord-023417-by18aczt	147	7	of	of	IN
cord-023417-by18aczt	147	8	MGL	MGL	NNP
cord-023417-by18aczt	147	9	expression	expression	NN
cord-023417-by18aczt	147	10	is	be	VBZ
cord-023417-by18aczt	147	11	similar	similar	JJ
cord-023417-by18aczt	147	12	in	in	IN
cord-023417-by18aczt	147	13	human	human	JJ
cord-023417-by18aczt	147	14	monocytes	monocyte	NNS
cord-023417-by18aczt	147	15	and	and	CC
cord-023417-by18aczt	147	16	monocyte	monocyte	NN
cord-023417-by18aczt	147	17	-	-	HYPH
cord-023417-by18aczt	147	18	derived	derive	VBN
cord-023417-by18aczt	147	19	macrophages	macrophage	NNS
cord-023417-by18aczt	147	20	.	.	.
cord-023417-by18aczt	148	1	Hence	hence	RB
cord-023417-by18aczt	148	2	,	,	,
cord-023417-by18aczt	148	3	macrophage	macrophage	NN
cord-023417-by18aczt	148	4	galactose	galactose	NN
cord-023417-by18aczt	148	5	-	-	HYPH
cord-023417-by18aczt	148	6	type	type	NN
cord-023417-by18aczt	148	7	C	c	NN
cord-023417-by18aczt	148	8	-	-	HYPH
cord-023417-by18aczt	148	9	type	type	NN
cord-023417-by18aczt	148	10	lectins	lectin	NNS
cord-023417-by18aczt	148	11	represent	represent	VBP
cord-023417-by18aczt	148	12	novel	novel	JJ
cord-023417-by18aczt	148	13	markers	marker	NNS
cord-023417-by18aczt	148	14	for	for	IN
cord-023417-by18aczt	148	15	both	both	CC
cord-023417-by18aczt	148	16	murine	murine	JJ
cord-023417-by18aczt	148	17	and	and	CC
cord-023417-by18aczt	148	18	human	human	JJ
cord-023417-by18aczt	148	19	alternatively	alternatively	RB
cord-023417-by18aczt	148	20	activated	activate	VBN
cord-023417-by18aczt	148	21	macrophages	macrophage	NNS
cord-023417-by18aczt	148	22	;	;	:
cord-023417-by18aczt	148	23	thus	thus	RB
cord-023417-by18aczt	148	24	,	,	,
cord-023417-by18aczt	148	25	paving	pave	VBG
cord-023417-by18aczt	148	26	the	the	DT
cord-023417-by18aczt	148	27	way	way	NN
cord-023417-by18aczt	148	28	for	for	IN
cord-023417-by18aczt	148	29	further	further	JJ
cord-023417-by18aczt	148	30	characterization	characterization	NN
cord-023417-by18aczt	148	31	of	of	IN
cord-023417-by18aczt	148	32	the	the	DT
cord-023417-by18aczt	148	33	phenotype	phenotype	NN
cord-023417-by18aczt	148	34	of	of	IN
cord-023417-by18aczt	148	35	macrophages	macrophage	NNS
cord-023417-by18aczt	148	36	occurring	occur	VBG
cord-023417-by18aczt	148	37	in	in	IN
cord-023417-by18aczt	148	38	Th2	th2	CD
cord-023417-by18aczt	148	39	conditions	condition	NNS
cord-023417-by18aczt	148	40	.	.	.
cord-023417-by18aczt	149	1	Background	background	NN
cord-023417-by18aczt	149	2	:	:	:
cord-023417-by18aczt	150	1	Human	human	JJ
cord-023417-by18aczt	150	2	parvovirus	parvovirus	NN
cord-023417-by18aczt	150	3	B19	B19	NNP
cord-023417-by18aczt	150	4	(	(	-LRB-
cord-023417-by18aczt	150	5	B19	B19	NNP
cord-023417-by18aczt	150	6	)	)	-RRB-
cord-023417-by18aczt	150	7	is	be	VBZ
cord-023417-by18aczt	150	8	a	a	DT
cord-023417-by18aczt	150	9	ubiquitous	ubiquitous	JJ
cord-023417-by18aczt	150	10	pathogen	pathogen	NN
cord-023417-by18aczt	150	11	,	,	,
cord-023417-by18aczt	150	12	normally	normally	RB
cord-023417-by18aczt	150	13	causing	cause	VBG
cord-023417-by18aczt	150	14	a	a	DT
cord-023417-by18aczt	150	15	mild	mild	JJ
cord-023417-by18aczt	150	16	self	self	NN
cord-023417-by18aczt	150	17	-	-	HYPH
cord-023417-by18aczt	150	18	limiting	limit	VBG
cord-023417-by18aczt	150	19	disease	disease	NN
cord-023417-by18aczt	150	20	,	,	,
cord-023417-by18aczt	150	21	but	but	CC
cord-023417-by18aczt	150	22	also	also	RB
cord-023417-by18aczt	150	23	capable	capable	JJ
cord-023417-by18aczt	150	24	of	of	IN
cord-023417-by18aczt	150	25	causing	cause	VBG
cord-023417-by18aczt	150	26	both	both	DT
cord-023417-by18aczt	150	27	significant	significant	JJ
cord-023417-by18aczt	150	28	pathology	pathology	NN
cord-023417-by18aczt	150	29	and	and	CC
cord-023417-by18aczt	150	30	long	long	JJ
cord-023417-by18aczt	150	31	-	-	HYPH
cord-023417-by18aczt	150	32	term	term	NN
cord-023417-by18aczt	150	33	persistence	persistence	NN
cord-023417-by18aczt	150	34	.	.	.
cord-023417-by18aczt	151	1	The	the	DT
cord-023417-by18aczt	151	2	small	small	JJ
cord-023417-by18aczt	151	3	size	size	NN
cord-023417-by18aczt	151	4	and	and	CC
cord-023417-by18aczt	151	5	stability	stability	NN
cord-023417-by18aczt	151	6	of	of	IN
cord-023417-by18aczt	151	7	the	the	DT
cord-023417-by18aczt	151	8	virus	virus	NN
cord-023417-by18aczt	151	9	makes	make	VBZ
cord-023417-by18aczt	151	10	it	-PRON-	PRP
cord-023417-by18aczt	151	11	suitable	suitable	JJ
cord-023417-by18aczt	151	12	for	for	IN
cord-023417-by18aczt	151	13	mapping	mapping	NN
cord-023417-by18aczt	151	14	of	of	IN
cord-023417-by18aczt	151	15	the	the	DT
cord-023417-by18aczt	151	16	full	full	JJ
cord-023417-by18aczt	151	17	breath	breath	NN
cord-023417-by18aczt	151	18	and	and	CC
cord-023417-by18aczt	151	19	the	the	DT
cord-023417-by18aczt	151	20	kinetics	kinetic	NNS
cord-023417-by18aczt	151	21	of	of	IN
cord-023417-by18aczt	151	22	the	the	DT
cord-023417-by18aczt	151	23	cellular	cellular	JJ
cord-023417-by18aczt	151	24	immune	immune	JJ
cord-023417-by18aczt	151	25	responses	response	NNS
cord-023417-by18aczt	151	26	following	follow	VBG
cord-023417-by18aczt	151	27	acute	acute	JJ
cord-023417-by18aczt	151	28	viral	viral	JJ
cord-023417-by18aczt	151	29	infection	infection	NN
cord-023417-by18aczt	151	30	.	.	.
cord-023417-by18aczt	152	1	Methods	method	NNS
cord-023417-by18aczt	152	2	:	:	:
cord-023417-by18aczt	152	3	Five	five	CD
cord-023417-by18aczt	152	4	patients	patient	NNS
cord-023417-by18aczt	152	5	with	with	IN
cord-023417-by18aczt	152	6	acute	acute	JJ
cord-023417-by18aczt	152	7	primary	primary	JJ
cord-023417-by18aczt	152	8	B19	B19	NNP
cord-023417-by18aczt	152	9	infection	infection	NN
cord-023417-by18aczt	152	10	were	be	VBD
cord-023417-by18aczt	152	11	included	include	VBN
cord-023417-by18aczt	152	12	in	in	IN
cord-023417-by18aczt	152	13	the	the	DT
cord-023417-by18aczt	152	14	study	study	NN
cord-023417-by18aczt	152	15	and	and	CC
cord-023417-by18aczt	152	16	followed	follow	VBD
cord-023417-by18aczt	152	17	consecutively	consecutively	RB
cord-023417-by18aczt	152	18	for	for	IN
cord-023417-by18aczt	152	19	up	up	IN
cord-023417-by18aczt	152	20	to	to	TO
cord-023417-by18aczt	152	21	200	200	CD
cord-023417-by18aczt	152	22	weeks	week	NNS
cord-023417-by18aczt	152	23	.	.	.
cord-023417-by18aczt	153	1	Cellular	cellular	JJ
cord-023417-by18aczt	153	2	immune	immune	JJ
cord-023417-by18aczt	153	3	responses	response	NNS
cord-023417-by18aczt	153	4	were	be	VBD
cord-023417-by18aczt	153	5	mapped	map	VBN
cord-023417-by18aczt	153	6	by	by	IN
cord-023417-by18aczt	153	7	IFNg	IFNg	NNP
cord-023417-by18aczt	153	8	enzyme	enzyme	NN
cord-023417-by18aczt	153	9	-	-	HYPH
cord-023417-by18aczt	153	10	linked	link	VBN
cord-023417-by18aczt	153	11	immunospot	immunospot	NN
cord-023417-by18aczt	153	12	to	to	IN
cord-023417-by18aczt	153	13	overlapping	overlap	VBG
cord-023417-by18aczt	153	14	peptides	peptide	NNS
cord-023417-by18aczt	153	15	spanning	span	VBG
cord-023417-by18aczt	153	16	the	the	DT
cord-023417-by18aczt	153	17	whole	whole	JJ
cord-023417-by18aczt	153	18	B19	B19	NNP
cord-023417-by18aczt	153	19	genome	genome	NN
cord-023417-by18aczt	153	20	.	.	.
cord-023417-by18aczt	154	1	Results	result	NNS
cord-023417-by18aczt	154	2	:	:	:
cord-023417-by18aczt	155	1	In	in	IN
cord-023417-by18aczt	155	2	all	all	DT
cord-023417-by18aczt	155	3	five	five	CD
cord-023417-by18aczt	155	4	acutely	acutely	RB
cord-023417-by18aczt	155	5	infected	infected	JJ
cord-023417-by18aczt	155	6	patients	patient	NNS
cord-023417-by18aczt	155	7	,	,	,
cord-023417-by18aczt	155	8	we	-PRON-	PRP
cord-023417-by18aczt	155	9	were	be	VBD
cord-023417-by18aczt	155	10	able	able	JJ
cord-023417-by18aczt	155	11	to	to	TO
cord-023417-by18aczt	155	12	monitor	monitor	VB
cord-023417-by18aczt	155	13	the	the	DT
cord-023417-by18aczt	155	14	kinetics	kinetic	NNS
cord-023417-by18aczt	155	15	of	of	IN
cord-023417-by18aczt	155	16	a	a	DT
cord-023417-by18aczt	155	17	strong	strong	JJ
cord-023417-by18aczt	155	18	specific	specific	JJ
cord-023417-by18aczt	155	19	cellular	cellular	JJ
cord-023417-by18aczt	155	20	immune	immune	JJ
cord-023417-by18aczt	155	21	reaction	reaction	NN
cord-023417-by18aczt	155	22	.	.	.
cord-023417-by18aczt	156	1	Responses	response	NNS
cord-023417-by18aczt	156	2	peaked	peak	VBD
cord-023417-by18aczt	156	3	at	at	IN
cord-023417-by18aczt	156	4	levels	level	NNS
cord-023417-by18aczt	156	5	of	of	IN
cord-023417-by18aczt	156	6	850	850	CD
cord-023417-by18aczt	156	7	-	-	HYPH
cord-023417-by18aczt	156	8	1850	1850	CD
cord-023417-by18aczt	156	9	SFC/	SFC/	NNP
cord-023417-by18aczt	156	10	million	million	CD
cord-023417-by18aczt	156	11	PBMCs	pbmc	NNS
cord-023417-by18aczt	156	12	,	,	,
cord-023417-by18aczt	156	13	roughly	roughly	RB
cord-023417-by18aczt	156	14	corresponding	correspond	VBG
cord-023417-by18aczt	156	15	to	to	IN
cord-023417-by18aczt	156	16	0.3	0.3	CD
cord-023417-by18aczt	156	17	-	-	SYM
cord-023417-by18aczt	156	18	0.6	0.6	CD
cord-023417-by18aczt	156	19	%	%	NN
cord-023417-by18aczt	156	20	B19specific	B19specific	NNP
cord-023417-by18aczt	156	21	CD8	CD8	NNP
cord-023417-by18aczt	156	22	þ	þ	NNP
cord-023417-by18aczt	156	23	cells	cell	NNS
cord-023417-by18aczt	156	24	circulating	circulate	VBG
cord-023417-by18aczt	156	25	in	in	IN
cord-023417-by18aczt	156	26	peripheral	peripheral	JJ
cord-023417-by18aczt	156	27	blood	blood	NN
cord-023417-by18aczt	156	28	at	at	IN
cord-023417-by18aczt	156	29	10	10	CD
cord-023417-by18aczt	156	30	-	-	SYM
cord-023417-by18aczt	156	31	80	80	CD
cord-023417-by18aczt	156	32	weeks	week	NNS
cord-023417-by18aczt	156	33	post	post	NN
cord-023417-by18aczt	156	34	-	-	NN
cord-023417-by18aczt	156	35	infection	infection	NN
cord-023417-by18aczt	156	36	.	.	.
cord-023417-by18aczt	157	1	The	the	DT
cord-023417-by18aczt	157	2	responses	response	NNS
cord-023417-by18aczt	157	3	in	in	IN
cord-023417-by18aczt	157	4	individual	individual	JJ
cord-023417-by18aczt	157	5	patients	patient	NNS
cord-023417-by18aczt	157	6	were	be	VBD
cord-023417-by18aczt	157	7	directed	direct	VBN
cord-023417-by18aczt	157	8	to	to	IN
cord-023417-by18aczt	157	9	three	three	CD
cord-023417-by18aczt	157	10	or	or	CC
cord-023417-by18aczt	157	11	four	four	CD
cord-023417-by18aczt	157	12	different	different	JJ
cord-023417-by18aczt	157	13	peptide	peptide	NN
cord-023417-by18aczt	157	14	pools	pool	NNS
cord-023417-by18aczt	157	15	,	,	,
cord-023417-by18aczt	157	16	and	and	CC
cord-023417-by18aczt	157	17	the	the	DT
cord-023417-by18aczt	157	18	specificity	specificity	NN
cord-023417-by18aczt	157	19	was	be	VBD
cord-023417-by18aczt	157	20	confined	confine	VBN
cord-023417-by18aczt	157	21	to	to	IN
cord-023417-by18aczt	157	22	the	the	DT
cord-023417-by18aczt	157	23	same	same	JJ
cord-023417-by18aczt	157	24	CD8	CD8	NNP
cord-023417-by18aczt	157	25	epitopes	epitope	NNS
cord-023417-by18aczt	157	26	present	present	JJ
cord-023417-by18aczt	157	27	in	in	IN
cord-023417-by18aczt	157	28	the	the	DT
cord-023417-by18aczt	157	29	pools	pool	NNS
cord-023417-by18aczt	157	30	throughout	throughout	IN
cord-023417-by18aczt	157	31	the	the	DT
cord-023417-by18aczt	157	32	follow	follow	NN
cord-023417-by18aczt	157	33	-	-	HYPH
cord-023417-by18aczt	157	34	up	up	NN
cord-023417-by18aczt	157	35	period	period	NN
cord-023417-by18aczt	157	36	.	.	.
cord-023417-by18aczt	158	1	The	the	DT
cord-023417-by18aczt	158	2	majority	majority	NN
cord-023417-by18aczt	158	3	of	of	IN
cord-023417-by18aczt	158	4	responses	response	NNS
cord-023417-by18aczt	158	5	were	be	VBD
cord-023417-by18aczt	158	6	directed	direct	VBN
cord-023417-by18aczt	158	7	to	to	IN
cord-023417-by18aczt	158	8	the	the	DT
cord-023417-by18aczt	158	9	virus	virus	NN
cord-023417-by18aczt	158	10	nonstructural	nonstructural	JJ
cord-023417-by18aczt	158	11	protein	protein	NN
cord-023417-by18aczt	158	12	,	,	,
cord-023417-by18aczt	158	13	only	only	RB
cord-023417-by18aczt	158	14	two	two	CD
cord-023417-by18aczt	158	15	patients	patient	NNS
cord-023417-by18aczt	158	16	showed	show	VBD
cord-023417-by18aczt	158	17	any	any	DT
cord-023417-by18aczt	158	18	response	response	NN
cord-023417-by18aczt	158	19	to	to	IN
cord-023417-by18aczt	158	20	the	the	DT
cord-023417-by18aczt	158	21	capsid	capsid	NN
cord-023417-by18aczt	158	22	proteins	protein	NNS
cord-023417-by18aczt	158	23	,	,	,
cord-023417-by18aczt	158	24	elicited	elicit	VBN
cord-023417-by18aczt	158	25	by	by	IN
cord-023417-by18aczt	158	26	the	the	DT
cord-023417-by18aczt	158	27	same	same	JJ
cord-023417-by18aczt	158	28	epitope	epitope	NN
cord-023417-by18aczt	158	29	in	in	IN
cord-023417-by18aczt	158	30	both	both	DT
cord-023417-by18aczt	158	31	cases	case	NNS
cord-023417-by18aczt	158	32	.	.	.
cord-023417-by18aczt	159	1	Conclusion	conclusion	NN
cord-023417-by18aczt	159	2	:	:	:
cord-023417-by18aczt	160	1	The	the	DT
cord-023417-by18aczt	160	2	cellular	cellular	JJ
cord-023417-by18aczt	160	3	immune	immune	JJ
cord-023417-by18aczt	160	4	responses	response	NNS
cord-023417-by18aczt	160	5	to	to	TO
cord-023417-by18aczt	160	6	acute	acute	JJ
cord-023417-by18aczt	160	7	B19	B19	NNP
cord-023417-by18aczt	160	8	infection	infection	NN
cord-023417-by18aczt	160	9	are	be	VBP
cord-023417-by18aczt	160	10	surprisingly	surprisingly	RB
cord-023417-by18aczt	160	11	narrow	narrow	JJ
cord-023417-by18aczt	160	12	in	in	IN
cord-023417-by18aczt	160	13	distribution	distribution	NN
cord-023417-by18aczt	160	14	and	and	CC
cord-023417-by18aczt	160	15	remain	remain	VB
cord-023417-by18aczt	160	16	at	at	IN
cord-023417-by18aczt	160	17	high	high	JJ
cord-023417-by18aczt	160	18	levels	level	NNS
cord-023417-by18aczt	160	19	for	for	IN
cord-023417-by18aczt	160	20	up	up	IN
cord-023417-by18aczt	160	21	to	to	TO
cord-023417-by18aczt	160	22	80	80	CD
cord-023417-by18aczt	160	23	weeks	week	NNS
cord-023417-by18aczt	160	24	post	post	NN
cord-023417-by18aczt	160	25	-	-	NN
cord-023417-by18aczt	160	26	infection	infection	NN
cord-023417-by18aczt	160	27	.	.	.
cord-023417-by18aczt	161	1	The	the	DT
cord-023417-by18aczt	161	2	initial	initial	JJ
cord-023417-by18aczt	161	3	epitope	epitope	NN
cord-023417-by18aczt	161	4	specificity	specificity	NN
cord-023417-by18aczt	161	5	is	be	VBZ
cord-023417-by18aczt	161	6	maintained	maintain	VBN
cord-023417-by18aczt	161	7	,	,	,
cord-023417-by18aczt	161	8	and	and	CC
cord-023417-by18aczt	161	9	the	the	DT
cord-023417-by18aczt	161	10	majority	majority	NN
cord-023417-by18aczt	161	11	of	of	IN
cord-023417-by18aczt	161	12	responses	response	NNS
cord-023417-by18aczt	161	13	target	target	VBP
cord-023417-by18aczt	161	14	the	the	DT
cord-023417-by18aczt	161	15	virus	virus	NN
cord-023417-by18aczt	161	16	nonstructural	nonstructural	JJ
cord-023417-by18aczt	161	17	protein	protein	NN
cord-023417-by18aczt	161	18	,	,	,
cord-023417-by18aczt	161	19	which	which	WDT
cord-023417-by18aczt	161	20	is	be	VBZ
cord-023417-by18aczt	161	21	not	not	RB
cord-023417-by18aczt	161	22	included	include	VBN
cord-023417-by18aczt	161	23	in	in	IN
cord-023417-by18aczt	161	24	vaccine	vaccine	NN
cord-023417-by18aczt	161	25	preparations	preparation	NNS
cord-023417-by18aczt	161	26	,	,	,
cord-023417-by18aczt	161	27	evaluated	evaluate	VBN
cord-023417-by18aczt	161	28	against	against	IN
cord-023417-by18aczt	161	29	the	the	DT
cord-023417-by18aczt	161	30	infection	infection	NN
cord-023417-by18aczt	161	31	.	.	.
cord-023417-by18aczt	162	1	The	the	DT
cord-023417-by18aczt	162	2	relationship	relationship	NN
cord-023417-by18aczt	162	3	between	between	IN
cord-023417-by18aczt	162	4	malnutrition	malnutrition	NN
cord-023417-by18aczt	162	5	and	and	CC
cord-023417-by18aczt	162	6	malaria	malaria	NN
cord-023417-by18aczt	162	7	is	be	VBZ
cord-023417-by18aczt	162	8	controversial	controversial	JJ
cord-023417-by18aczt	162	9	.	.	.
cord-023417-by18aczt	163	1	On	on	IN
cord-023417-by18aczt	163	2	one	one	CD
cord-023417-by18aczt	163	3	hand	hand	NN
cord-023417-by18aczt	163	4	,	,	,
cord-023417-by18aczt	163	5	malaria	malaria	NN
cord-023417-by18aczt	163	6	may	may	MD
cord-023417-by18aczt	163	7	cause	cause	VB
cord-023417-by18aczt	163	8	malnutrition	malnutrition	NN
cord-023417-by18aczt	163	9	,	,	,
cord-023417-by18aczt	163	10	while	while	IN
cord-023417-by18aczt	163	11	on	on	IN
cord-023417-by18aczt	163	12	the	the	DT
cord-023417-by18aczt	163	13	other	other	JJ
cord-023417-by18aczt	163	14	,	,	,
cord-023417-by18aczt	163	15	malnutrition	malnutrition	NN
cord-023417-by18aczt	163	16	itself	-PRON-	PRP
cord-023417-by18aczt	163	17	may	may	MD
cord-023417-by18aczt	163	18	modulate	modulate	VB
cord-023417-by18aczt	163	19	susceptibility	susceptibility	NN
cord-023417-by18aczt	163	20	to	to	IN
cord-023417-by18aczt	163	21	the	the	DT
cord-023417-by18aczt	163	22	disease	disease	NN
cord-023417-by18aczt	163	23	.	.	.
cord-023417-by18aczt	164	1	We	-PRON-	PRP
cord-023417-by18aczt	164	2	investigated	investigate	VBD
cord-023417-by18aczt	164	3	the	the	DT
cord-023417-by18aczt	164	4	association	association	NN
cord-023417-by18aczt	164	5	between	between	IN
cord-023417-by18aczt	164	6	Plasmodium	Plasmodium	NNP
cord-023417-by18aczt	164	7	falciparum	falciparum	NN
cord-023417-by18aczt	164	8	malaria	malaria	NN
cord-023417-by18aczt	164	9	and	and	CC
cord-023417-by18aczt	164	10	malnutrition	malnutrition	NN
cord-023417-by18aczt	164	11	in	in	IN
cord-023417-by18aczt	164	12	a	a	DT
cord-023417-by18aczt	164	13	cohort	cohort	NN
cord-023417-by18aczt	164	14	of	of	IN
cord-023417-by18aczt	164	15	children	child	NNS
cord-023417-by18aczt	164	16	living	live	VBG
cord-023417-by18aczt	164	17	on	on	IN
cord-023417-by18aczt	164	18	the	the	DT
cord-023417-by18aczt	164	19	coast	coast	NN
cord-023417-by18aczt	164	20	of	of	IN
cord-023417-by18aczt	164	21	Kenya	Kenya	NNP
cord-023417-by18aczt	164	22	.	.	.
cord-023417-by18aczt	165	1	The	the	DT
cord-023417-by18aczt	165	2	study	study	NN
cord-023417-by18aczt	165	3	involved	involve	VBD
cord-023417-by18aczt	165	4	longitudinal	longitudinal	JJ
cord-023417-by18aczt	165	5	follow	follow	NN
cord-023417-by18aczt	165	6	-	-	HYPH
cord-023417-by18aczt	165	7	up	up	NN
cord-023417-by18aczt	165	8	for	for	IN
cord-023417-by18aczt	165	9	clinical	clinical	JJ
cord-023417-by18aczt	165	10	malaria	malaria	NN
cord-023417-by18aczt	165	11	episodes	episode	NNS
cord-023417-by18aczt	165	12	and	and	CC
cord-023417-by18aczt	165	13	anthropometric	anthropometric	JJ
cord-023417-by18aczt	165	14	measurements	measurement	NNS
cord-023417-by18aczt	165	15	at	at	IN
cord-023417-by18aczt	165	16	four	four	CD
cord-023417-by18aczt	165	17	cross	cross	JJ
cord-023417-by18aczt	165	18	-	-	JJ
cord-023417-by18aczt	165	19	sectional	sectional	JJ
cord-023417-by18aczt	165	20	surveys	survey	NNS
cord-023417-by18aczt	165	21	.	.	.
cord-023417-by18aczt	166	1	We	-PRON-	PRP
cord-023417-by18aczt	166	2	used	use	VBD
cord-023417-by18aczt	166	3	Poisson	Poisson	NNP
cord-023417-by18aczt	166	4	regression	regression	NN
cord-023417-by18aczt	166	5	analysis	analysis	NN
cord-023417-by18aczt	166	6	to	to	TO
cord-023417-by18aczt	166	7	investigate	investigate	VB
cord-023417-by18aczt	166	8	the	the	DT
cord-023417-by18aczt	166	9	association	association	NN
cord-023417-by18aczt	166	10	between	between	IN
cord-023417-by18aczt	166	11	malaria	malaria	NNP
cord-023417-by18aczt	166	12	and	and	CC
cord-023417-by18aczt	166	13	nutritional	nutritional	JJ
cord-023417-by18aczt	166	14	status	status	NN
cord-023417-by18aczt	166	15	.	.	.
cord-023417-by18aczt	167	1	Compared	compare	VBN
cord-023417-by18aczt	167	2	to	to	IN
cord-023417-by18aczt	167	3	baseline	baseline	JJ
cord-023417-by18aczt	167	4	(	(	-LRB-
cord-023417-by18aczt	167	5	children	child	NNS
cord-023417-by18aczt	167	6	with	with	IN
cord-023417-by18aczt	167	7	a	a	DT
cord-023417-by18aczt	167	8	WAZ	WAZ	NNP
cord-023417-by18aczt	167	9	or	or	CC
cord-023417-by18aczt	167	10	HAZ	haz	NN
cord-023417-by18aczt	167	11	score	score	NN
cord-023417-by18aczt	167	12	of	of	IN
cord-023417-by18aczt	167	13	!	!	.
cord-023417-by18aczt	168	1	À2	À2	NNP
cord-023417-by18aczt	168	2	)	)	-RRB-
cord-023417-by18aczt	168	3	,	,	,
cord-023417-by18aczt	168	4	the	the	DT
cord-023417-by18aczt	168	5	crude	crude	JJ
cord-023417-by18aczt	168	6	incidence	incidence	NN
cord-023417-by18aczt	168	7	rate	rate	NN
cord-023417-by18aczt	168	8	ratios	ratio	NNS
cord-023417-by18aczt	168	9	(	(	-LRB-
cord-023417-by18aczt	168	10	IRRs	IRRs	NNP
cord-023417-by18aczt	168	11	)	)	-RRB-
cord-023417-by18aczt	168	12	for	for	IN
cord-023417-by18aczt	168	13	malaria	malaria	NN
cord-023417-by18aczt	168	14	in	in	IN
cord-023417-by18aczt	168	15	children	child	NNS
cord-023417-by18aczt	168	16	with	with	IN
cord-023417-by18aczt	168	17	low	low	JJ
cord-023417-by18aczt	168	18	HAZ	haz	NN
cord-023417-by18aczt	168	19	or	or	CC
cord-023417-by18aczt	168	20	WAZ	WAZ	NNP
cord-023417-by18aczt	168	21	scores	score	NNS
cord-023417-by18aczt	168	22	(	(	-LRB-
cord-023417-by18aczt	168	23	<	<	XX
cord-023417-by18aczt	168	24	À2	À2	NNP
cord-023417-by18aczt	168	25	)	)	-RRB-
cord-023417-by18aczt	168	26	during	during	IN
cord-023417-by18aczt	168	27	the	the	DT
cord-023417-by18aczt	168	28	period	period	NN
cord-023417-by18aczt	168	29	prior	prior	RB
cord-023417-by18aczt	168	30	to	to	IN
cord-023417-by18aczt	168	31	assessment	assessment	NN
cord-023417-by18aczt	168	32	were	be	VBD
cord-023417-by18aczt	168	33	1.17	1.17	CD
cord-023417-by18aczt	169	1	(	(	-LRB-
cord-023417-by18aczt	169	2	95	95	CD
cord-023417-by18aczt	169	3	%	%	NN
cord-023417-by18aczt	169	4	CI	CI	NNP
cord-023417-by18aczt	169	5	0.91	0.91	CD
cord-023417-by18aczt	169	6	-	-	HYPH
cord-023417-by18aczt	169	7	1.50	1.50	CD
cord-023417-by18aczt	169	8	;	;	:
cord-023417-by18aczt	169	9	0	0	CD
cord-023417-by18aczt	169	10	¼	¼	CD
cord-023417-by18aczt	169	11	0.21	0.21	CD
cord-023417-by18aczt	169	12	)	)	-RRB-
cord-023417-by18aczt	169	13	and	and	CC
cord-023417-by18aczt	169	14	0.94	0.94	CD
cord-023417-by18aczt	169	15	(	(	-LRB-
cord-023417-by18aczt	169	16	0.71	0.71	CD
cord-023417-by18aczt	169	17	-	-	SYM
cord-023417-by18aczt	169	18	1.25	1.25	CD
cord-023417-by18aczt	169	19	;	;	:
cord-023417-by18aczt	169	20	0.67	0.67	CD
cord-023417-by18aczt	169	21	)	)	-RRB-
cord-023417-by18aczt	169	22	,	,	,
cord-023417-by18aczt	169	23	respectively	respectively	RB
cord-023417-by18aczt	169	24	,	,	,
cord-023417-by18aczt	169	25	suggesting	suggest	VBG
cord-023417-by18aczt	169	26	no	no	DT
cord-023417-by18aczt	169	27	association	association	NN
cord-023417-by18aczt	169	28	between	between	IN
cord-023417-by18aczt	169	29	malaria	malaria	NN
cord-023417-by18aczt	169	30	and	and	CC
cord-023417-by18aczt	169	31	the	the	DT
cord-023417-by18aczt	169	32	subsequent	subsequent	JJ
cord-023417-by18aczt	169	33	development	development	NN
cord-023417-by18aczt	169	34	of	of	IN
cord-023417-by18aczt	169	35	PEM	PEM	NNP
cord-023417-by18aczt	169	36	.	.	.
cord-023417-by18aczt	170	1	However	however	RB
cord-023417-by18aczt	170	2	,	,	,
cord-023417-by18aczt	170	3	we	-PRON-	PRP
cord-023417-by18aczt	170	4	found	find	VBD
cord-023417-by18aczt	170	5	that	that	IN
cord-023417-by18aczt	170	6	age	age	NN
cord-023417-by18aczt	170	7	was	be	VBD
cord-023417-by18aczt	170	8	acting	act	VBG
cord-023417-by18aczt	170	9	as	as	IN
cord-023417-by18aczt	170	10	an	an	DT
cord-023417-by18aczt	170	11	effect	effect	NN
cord-023417-by18aczt	170	12	modifier	modifier	NN
cord-023417-by18aczt	170	13	in	in	IN
cord-023417-by18aczt	170	14	the	the	DT
cord-023417-by18aczt	170	15	association	association	NN
cord-023417-by18aczt	170	16	between	between	IN
cord-023417-by18aczt	170	17	malaria	malaria	NN
cord-023417-by18aczt	170	18	and	and	CC
cord-023417-by18aczt	170	19	malnutrition	malnutrition	NN
cord-023417-by18aczt	170	20	.	.	.
cord-023417-by18aczt	171	1	The	the	DT
cord-023417-by18aczt	171	2	IRR	IRR	NNP
cord-023417-by18aczt	171	3	for	for	IN
cord-023417-by18aczt	171	4	malaria	malaria	NN
cord-023417-by18aczt	171	5	in	in	IN
cord-023417-by18aczt	171	6	children	child	NNS
cord-023417-by18aczt	171	7	0	0	CD
cord-023417-by18aczt	171	8	-	-	SYM
cord-023417-by18aczt	171	9	2	2	CD
cord-023417-by18aczt	171	10	years	year	NNS
cord-023417-by18aczt	171	11	old	old	JJ
cord-023417-by18aczt	171	12	who	who	WP
cord-023417-by18aczt	171	13	were	be	VBD
cord-023417-by18aczt	171	14	subsequently	subsequently	RB
cord-023417-by18aczt	171	15	characterized	characterize	VBN
cord-023417-by18aczt	171	16	as	as	IN
cord-023417-by18aczt	171	17	wasted	waste	VBN
cord-023417-by18aczt	171	18	was	be	VBD
cord-023417-by18aczt	171	19	1.65	1.65	CD
cord-023417-by18aczt	171	20	(	(	-LRB-
cord-023417-by18aczt	171	21	1.10	1.10	CD
cord-023417-by18aczt	171	22	-	-	SYM
cord-023417-by18aczt	171	23	2.20	2.20	CD
cord-023417-by18aczt	171	24	;	;	.
cord-023417-by18aczt	172	1	P	p	NN
cord-023417-by18aczt	172	2	¼	¼	CD
cord-023417-by18aczt	172	3	0.01	0.01	CD
cord-023417-by18aczt	172	4	)	)	-RRB-
cord-023417-by18aczt	172	5	,	,	,
cord-023417-by18aczt	172	6	and	and	CC
cord-023417-by18aczt	173	1	a	a	DT
cord-023417-by18aczt	173	2	significant	significant	JJ
cord-023417-by18aczt	173	3	overall	overall	JJ
cord-023417-by18aczt	173	4	relationship	relationship	NN
cord-023417-by18aczt	173	5	between	between	IN
cord-023417-by18aczt	173	6	malaria	malaria	NN
cord-023417-by18aczt	173	7	and	and	CC
cord-023417-by18aczt	173	8	low	low	JJ
cord-023417-by18aczt	173	9	-	-	HYPH
cord-023417-by18aczt	173	10	HAZ	haz	NN
cord-023417-by18aczt	173	11	was	be	VBD
cord-023417-by18aczt	173	12	found	find	VBN
cord-023417-by18aczt	173	13	on	on	IN
cord-023417-by18aczt	173	14	regression	regression	NN
cord-023417-by18aczt	173	15	analysis	analysis	NN
cord-023417-by18aczt	173	16	when	when	WRB
cord-023417-by18aczt	173	17	adjusting	adjust	VBG
cord-023417-by18aczt	173	18	for	for	IN
cord-023417-by18aczt	173	19	the	the	DT
cord-023417-by18aczt	173	20	interaction	interaction	NN
cord-023417-by18aczt	173	21	with	with	IN
cord-023417-by18aczt	173	22	age	age	NN
cord-023417-by18aczt	173	23	(	(	-LRB-
cord-023417-by18aczt	173	24	IRR	IRR	NNP
cord-023417-by18aczt	173	25	1.89	1.89	CD
cord-023417-by18aczt	173	26	;	;	:
cord-023417-by18aczt	173	27	1.01	1.01	CD
cord-023417-by18aczt	173	28	-	-	HYPH
cord-023417-by18aczt	173	29	3.53	3.53	CD
cord-023417-by18aczt	173	30	;	;	:
cord-023417-by18aczt	173	31	P	p	NN
cord-023417-by18aczt	173	32	<	<	XX
cord-023417-by18aczt	173	33	0.05	0.05	CD
cord-023417-by18aczt	173	34	)	)	-RRB-
cord-023417-by18aczt	173	35	.	.	.
cord-023417-by18aczt	174	1	Although	although	IN
cord-023417-by18aczt	174	2	children	child	NNS
cord-023417-by18aczt	174	3	living	live	VBG
cord-023417-by18aczt	174	4	on	on	IN
cord-023417-by18aczt	174	5	the	the	DT
cord-023417-by18aczt	174	6	coast	coast	NN
cord-023417-by18aczt	174	7	of	of	IN
cord-023417-by18aczt	174	8	Kenya	Kenya	NNP
cord-023417-by18aczt	174	9	continue	continue	VBP
cord-023417-by18aczt	174	10	to	to	TO
cord-023417-by18aczt	174	11	suffer	suffer	VB
cord-023417-by18aczt	174	12	clinical	clinical	JJ
cord-023417-by18aczt	174	13	episodes	episode	NNS
cord-023417-by18aczt	174	14	of	of	IN
cord-023417-by18aczt	174	15	uncomplicated	uncomplicated	JJ
cord-023417-by18aczt	174	16	malaria	malaria	NN
cord-023417-by18aczt	174	17	throughout	throughout	IN
cord-023417-by18aczt	174	18	their	-PRON-	PRP$
cord-023417-by18aczt	174	19	first	first	JJ
cord-023417-by18aczt	174	20	decade	decade	NN
cord-023417-by18aczt	174	21	,	,	,
cord-023417-by18aczt	174	22	the	the	DT
cord-023417-by18aczt	174	23	association	association	NN
cord-023417-by18aczt	174	24	between	between	IN
cord-023417-by18aczt	174	25	malaria	malaria	NN
cord-023417-by18aczt	174	26	and	and	CC
cord-023417-by18aczt	174	27	malnutrition	malnutrition	NN
cord-023417-by18aczt	174	28	appears	appear	VBZ
cord-023417-by18aczt	174	29	to	to	TO
cord-023417-by18aczt	174	30	be	be	VB
cord-023417-by18aczt	174	31	limited	limit	VBN
cord-023417-by18aczt	174	32	to	to	IN
cord-023417-by18aczt	174	33	the	the	DT
cord-023417-by18aczt	174	34	first	first	JJ
cord-023417-by18aczt	174	35	2	2	CD
cord-023417-by18aczt	174	36	years	year	NNS
cord-023417-by18aczt	174	37	of	of	IN
cord-023417-by18aczt	174	38	life	life	NN
cord-023417-by18aczt	174	39	.	.	.
cord-023417-by18aczt	175	1	A.	A.	NNP
cord-023417-by18aczt	175	2	Astrinidou	Astrinidou	NNP
cord-023417-by18aczt	175	3	-	-	HYPH
cord-023417-by18aczt	175	4	Vakaloudi	Vakaloudi	NNP
cord-023417-by18aczt	175	5	,	,	,
cord-023417-by18aczt	175	6	1	1	CD
cord-023417-by18aczt	175	7	S.	S.	NNP
cord-023417-by18aczt	175	8	Xytsas	Xytsas	NNP
cord-023417-by18aczt	175	9	,	,	,
cord-023417-by18aczt	175	10	1	1	CD
cord-023417-by18aczt	175	11	I.	i.	NN
cord-023417-by18aczt	175	12	Diamanti	Diamanti	NNP
cord-023417-by18aczt	175	13	,	,	,
cord-023417-by18aczt	175	14	1	1	CD
cord-023417-by18aczt	175	15	H.	H.	NNP
cord-023417-by18aczt	175	16	Ioannidis	Ioannidis	NNP
cord-023417-by18aczt	175	17	2	2	CD
cord-023417-by18aczt	175	18	&	&	CC
cord-023417-by18aczt	175	19	P.	P.	NNP
cord-023417-by18aczt	175	20	Pangidis	Pangidis	NNP
cord-023417-by18aczt	175	21	2	2	CD
cord-023417-by18aczt	175	22	1	1	CD
cord-023417-by18aczt	175	23	Microbiology	Microbiology	NNP
cord-023417-by18aczt	175	24	Department	Department	NNP
cord-023417-by18aczt	175	25	of	of	IN
cord-023417-by18aczt	175	26	General	General	NNP
cord-023417-by18aczt	175	27	Hospital	Hospital	NNP
cord-023417-by18aczt	175	28	of	of	IN
cord-023417-by18aczt	175	29	Thessaloniki	Thessaloniki	NNP
cord-023417-by18aczt	175	30	'	'	POS
cord-023417-by18aczt	175	31	Agios	Agios	NNP
cord-023417-by18aczt	175	32	Pavlos	Pavlos	NNP
cord-023417-by18aczt	175	33	'	'	POS
cord-023417-by18aczt	175	34	,	,	,
cord-023417-by18aczt	175	35	Thessaloniki	Thessaloniki	NNP
cord-023417-by18aczt	175	36	,	,	,
cord-023417-by18aczt	175	37	Greece	Greece	NNP
cord-023417-by18aczt	175	38	,	,	,
cord-023417-by18aczt	175	39	and	and	CC
cord-023417-by18aczt	175	40	2	2	CD
cord-023417-by18aczt	175	41	Nefrology	Nefrology	NNP
cord-023417-by18aczt	175	42	,	,	,
cord-023417-by18aczt	175	43	2	2	CD
cord-023417-by18aczt	175	44	nd	nd	NNP
cord-023417-by18aczt	175	45	IKA	IKA	NNP
cord-023417-by18aczt	175	46	Hospital	Hospital	NNP
cord-023417-by18aczt	175	47	of	of	IN
cord-023417-by18aczt	175	48	Thessaloniki	Thessaloniki	NNP
cord-023417-by18aczt	175	49	,	,	,
cord-023417-by18aczt	175	50	Thessaloniki	Thessaloniki	NNP
cord-023417-by18aczt	175	51	,	,	,
cord-023417-by18aczt	175	52	Greece	Greece	NNP
cord-023417-by18aczt	175	53	.	.	.
cord-023417-by18aczt	176	1	E	e	NN
cord-023417-by18aczt	176	2	-	-	NN
cord-023417-by18aczt	176	3	mail	mail	NN
cord-023417-by18aczt	176	4	:	:	:
cord-023417-by18aczt	176	5	stasa@hol.gr	stasa@hol.gr	NNP
cord-023417-by18aczt	176	6	Aim	aim	VB
cord-023417-by18aczt	176	7	:	:	:
cord-023417-by18aczt	176	8	Renal	renal	JJ
cord-023417-by18aczt	176	9	dysfunction	dysfunction	NN
cord-023417-by18aczt	176	10	may	may	MD
cord-023417-by18aczt	176	11	influence	influence	VB
cord-023417-by18aczt	176	12	the	the	DT
cord-023417-by18aczt	176	13	colonization	colonization	NN
cord-023417-by18aczt	176	14	of	of	IN
cord-023417-by18aczt	176	15	gastric	gastric	JJ
cord-023417-by18aczt	176	16	mucosa	mucosa	NN
cord-023417-by18aczt	176	17	by	by	IN
cord-023417-by18aczt	176	18	urea	urea	NN
cord-023417-by18aczt	176	19	-	-	HYPH
cord-023417-by18aczt	176	20	splitting	split	VBG
cord-023417-by18aczt	176	21	bacteria	bacteria	NNS
cord-023417-by18aczt	176	22	such	such	JJ
cord-023417-by18aczt	176	23	as	as	IN
cord-023417-by18aczt	176	24	Helicobacter	Helicobacter	NNP
cord-023417-by18aczt	176	25	pylori	pylori	NN
cord-023417-by18aczt	176	26	,	,	,
cord-023417-by18aczt	176	27	by	by	IN
cord-023417-by18aczt	176	28	increasing	increase	VBG
cord-023417-by18aczt	176	29	urea	urea	NN
cord-023417-by18aczt	176	30	concentrations	concentration	NNS
cord-023417-by18aczt	176	31	in	in	IN
cord-023417-by18aczt	176	32	the	the	DT
cord-023417-by18aczt	176	33	gastric	gastric	JJ
cord-023417-by18aczt	176	34	juice	juice	NN
cord-023417-by18aczt	176	35	.	.	.
cord-023417-by18aczt	177	1	Our	-PRON-	PRP$
cord-023417-by18aczt	177	2	aim	aim	NN
cord-023417-by18aczt	177	3	was	be	VBD
cord-023417-by18aczt	177	4	to	to	TO
cord-023417-by18aczt	177	5	investigate	investigate	VB
cord-023417-by18aczt	177	6	the	the	DT
cord-023417-by18aczt	177	7	prevalence	prevalence	NN
cord-023417-by18aczt	177	8	of	of	IN
cord-023417-by18aczt	177	9	H.	h.	NN
cord-023417-by18aczt	177	10	pylori	pylori	NN
cord-023417-by18aczt	177	11	in	in	IN
cord-023417-by18aczt	177	12	patients	patient	NNS
cord-023417-by18aczt	177	13	with	with	IN
cord-023417-by18aczt	177	14	end	end	NN
cord-023417-by18aczt	177	15	-	-	HYPH
cord-023417-by18aczt	177	16	stage	stage	NN
cord-023417-by18aczt	177	17	renal	renal	JJ
cord-023417-by18aczt	177	18	disease	disease	NN
cord-023417-by18aczt	177	19	(	(	-LRB-
cord-023417-by18aczt	177	20	ESRD	ESRD	NNP
cord-023417-by18aczt	177	21	)	)	-RRB-
cord-023417-by18aczt	177	22	,	,	,
cord-023417-by18aczt	177	23	receiving	receive	VBG
cord-023417-by18aczt	177	24	long	long	JJ
cord-023417-by18aczt	177	25	-	-	HYPH
cord-023417-by18aczt	177	26	term	term	NN
cord-023417-by18aczt	177	27	haemodialysis	haemodialysis	NN
cord-023417-by18aczt	177	28	treatment	treatment	NN
cord-023417-by18aczt	177	29	.	.	.
cord-023417-by18aczt	178	1	Methods	method	NNS
cord-023417-by18aczt	178	2	:	:	:
cord-023417-by18aczt	179	1	This	this	DT
cord-023417-by18aczt	179	2	study	study	NN
cord-023417-by18aczt	179	3	included	include	VBD
cord-023417-by18aczt	179	4	40	40	CD
cord-023417-by18aczt	179	5	sera	sera	NNP
cord-023417-by18aczt	179	6	from	from	IN
cord-023417-by18aczt	179	7	patients	patient	NNS
cord-023417-by18aczt	179	8	with	with	IN
cord-023417-by18aczt	179	9	ESRD	ESRD	NNP
cord-023417-by18aczt	179	10	(	(	-LRB-
cord-023417-by18aczt	179	11	29	29	CD
cord-023417-by18aczt	179	12	male	male	NN
cord-023417-by18aczt	179	13	and	and	CC
cord-023417-by18aczt	179	14	11	11	CD
cord-023417-by18aczt	179	15	female	female	JJ
cord-023417-by18aczt	179	16	)	)	-RRB-
cord-023417-by18aczt	179	17	undergoing	undergo	VBG
cord-023417-by18aczt	179	18	periodic	periodic	JJ
cord-023417-by18aczt	179	19	haemodialysis	haemodialysis	NN
cord-023417-by18aczt	179	20	;	;	:
cord-023417-by18aczt	179	21	mean	mean	JJ
cord-023417-by18aczt	179	22	time	time	NN
cord-023417-by18aczt	179	23	of	of	IN
cord-023417-by18aczt	179	24	treatment	treatment	NN
cord-023417-by18aczt	179	25	was	be	VBD
cord-023417-by18aczt	179	26	42.6	42.6	CD
cord-023417-by18aczt	179	27	months	month	NNS
cord-023417-by18aczt	179	28	.	.	.
cord-023417-by18aczt	180	1	Using	use	VBG
cord-023417-by18aczt	180	2	ELISA	ELISA	NNP
cord-023417-by18aczt	180	3	technique	technique	NN
cord-023417-by18aczt	180	4	,	,	,
cord-023417-by18aczt	180	5	we	-PRON-	PRP
cord-023417-by18aczt	180	6	investigated	investigate	VBD
cord-023417-by18aczt	180	7	the	the	DT
cord-023417-by18aczt	180	8	presence	presence	NN
cord-023417-by18aczt	180	9	of	of	IN
cord-023417-by18aczt	180	10	IgG	IgG	NNP
cord-023417-by18aczt	180	11	and	and	CC
cord-023417-by18aczt	180	12	IgA	IgA	NNP
cord-023417-by18aczt	180	13	antibodies	antibody	NNS
cord-023417-by18aczt	180	14	against	against	IN
cord-023417-by18aczt	180	15	H.	H.	NNP
cord-023417-by18aczt	180	16	pylori	pylori	NN
cord-023417-by18aczt	180	17	as	as	RB
cord-023417-by18aczt	180	18	well	well	RB
cord-023417-by18aczt	180	19	as	as	IN
cord-023417-by18aczt	180	20	IgG	IgG	NNP
cord-023417-by18aczt	180	21	CagA	CagA	NNP
cord-023417-by18aczt	180	22	(	(	-LRB-
cord-023417-by18aczt	180	23	antibodies	antibody	NNS
cord-023417-by18aczt	180	24	specific	specific	JJ
cord-023417-by18aczt	180	25	for	for	IN
cord-023417-by18aczt	180	26	CagA(þ	CagA(þ	NNS
cord-023417-by18aczt	180	27	)	)	-RRB-
cord-023417-by18aczt	180	28	strains	strain	NNS
cord-023417-by18aczt	180	29	of	of	IN
cord-023417-by18aczt	180	30	H.	H.	NNP
cord-023417-by18aczt	180	31	pylori	pylori	NN
cord-023417-by18aczt	180	32	)	)	-RRB-
cord-023417-by18aczt	180	33	.	.	.
cord-023417-by18aczt	181	1	Sera	Sera	NNP
cord-023417-by18aczt	181	2	from	from	IN
cord-023417-by18aczt	181	3	40	40	CD
cord-023417-by18aczt	181	4	healthy	healthy	JJ
cord-023417-by18aczt	181	5	blood	blood	NN
cord-023417-by18aczt	181	6	donors	donor	NNS
cord-023417-by18aczt	181	7	were	be	VBD
cord-023417-by18aczt	181	8	used	use	VBN
cord-023417-by18aczt	181	9	as	as	IN
cord-023417-by18aczt	181	10	a	a	DT
cord-023417-by18aczt	181	11	control	control	NN
cord-023417-by18aczt	181	12	group	group	NN
cord-023417-by18aczt	181	13	.	.	.
cord-023417-by18aczt	182	1	Results	result	NNS
cord-023417-by18aczt	182	2	:	:	:
cord-023417-by18aczt	183	1	H.	H.	NNP
cord-023417-by18aczt	183	2	pylori	pylori	NNP
cord-023417-by18aczt	183	3	IgG	IgG	NNP
cord-023417-by18aczt	183	4	antibodies	antibody	NNS
cord-023417-by18aczt	183	5	were	be	VBD
cord-023417-by18aczt	183	6	detected	detect	VBN
cord-023417-by18aczt	183	7	in	in	IN
cord-023417-by18aczt	183	8	32	32	CD
cord-023417-by18aczt	183	9	out	out	IN
cord-023417-by18aczt	183	10	of	of	IN
cord-023417-by18aczt	183	11	40	40	CD
cord-023417-by18aczt	183	12	(	(	-LRB-
cord-023417-by18aczt	183	13	80	80	CD
cord-023417-by18aczt	183	14	%	%	NN
cord-023417-by18aczt	183	15	)	)	-RRB-
cord-023417-by18aczt	183	16	patients	patient	NNS
cord-023417-by18aczt	183	17	in	in	IN
cord-023417-by18aczt	183	18	the	the	DT
cord-023417-by18aczt	183	19	dialysis	dialysis	NN
cord-023417-by18aczt	183	20	group	group	NN
cord-023417-by18aczt	183	21	,	,	,
cord-023417-by18aczt	183	22	while	while	IN
cord-023417-by18aczt	183	23	31/40	31/40	CD
cord-023417-by18aczt	183	24	(	(	-LRB-
cord-023417-by18aczt	183	25	77.5	77.5	CD
cord-023417-by18aczt	183	26	%	%	NN
cord-023417-by18aczt	183	27	)	)	-RRB-
cord-023417-by18aczt	183	28	tested	test	VBD
cord-023417-by18aczt	183	29	positive	positive	JJ
cord-023417-by18aczt	183	30	for	for	IN
cord-023417-by18aczt	184	1	IgA.	IgA.	NNP
cord-023417-by18aczt	185	1	IgG	IgG	NNP
cord-023417-by18aczt	185	2	CagA	CagA	NNP
cord-023417-by18aczt	185	3	antibodies	antibody	NNS
cord-023417-by18aczt	185	4	were	be	VBD
cord-023417-by18aczt	185	5	present	present	JJ
cord-023417-by18aczt	185	6	in	in	IN
cord-023417-by18aczt	185	7	13	13	CD
cord-023417-by18aczt	185	8	out	out	IN
cord-023417-by18aczt	185	9	of	of	IN
cord-023417-by18aczt	185	10	40	40	CD
cord-023417-by18aczt	185	11	(	(	-LRB-
cord-023417-by18aczt	185	12	32.5	32.5	CD
cord-023417-by18aczt	185	13	%	%	NN
cord-023417-by18aczt	185	14	)	)	-RRB-
cord-023417-by18aczt	185	15	.	.	.
cord-023417-by18aczt	186	1	Prevalence	prevalence	NN
cord-023417-by18aczt	186	2	of	of	IN
cord-023417-by18aczt	186	3	H.	H.	NNP
cord-023417-by18aczt	186	4	pylori	pylori	NNP
cord-023417-by18aczt	186	5	IgG	IgG	NNP
cord-023417-by18aczt	186	6	,	,	,
cord-023417-by18aczt	186	7	IgA	IgA	NNP
cord-023417-by18aczt	186	8	and	and	CC
cord-023417-by18aczt	186	9	CagA	CagA	NNP
cord-023417-by18aczt	186	10	IgG	IgG	NNP
cord-023417-by18aczt	186	11	antibodies	antibody	NNS
cord-023417-by18aczt	186	12	in	in	IN
cord-023417-by18aczt	186	13	the	the	DT
cord-023417-by18aczt	186	14	control	control	NN
cord-023417-by18aczt	186	15	group	group	NN
cord-023417-by18aczt	186	16	was	be	VBD
cord-023417-by18aczt	186	17	33	33	CD
cord-023417-by18aczt	186	18	,	,	,
cord-023417-by18aczt	186	19	7	7	CD
cord-023417-by18aczt	186	20	and	and	CC
cord-023417-by18aczt	186	21	15	15	CD
cord-023417-by18aczt	186	22	%	%	NN
cord-023417-by18aczt	186	23	,	,	,
cord-023417-by18aczt	186	24	respectively	respectively	RB
cord-023417-by18aczt	186	25	.	.	.
cord-023417-by18aczt	187	1	Conclusions	conclusion	NNS
cord-023417-by18aczt	187	2	:	:	:
cord-023417-by18aczt	188	1	Although	although	IN
cord-023417-by18aczt	188	2	international	international	JJ
cord-023417-by18aczt	188	3	data	datum	NNS
cord-023417-by18aczt	188	4	suggest	suggest	VBP
cord-023417-by18aczt	188	5	that	that	IN
cord-023417-by18aczt	188	6	prevalence	prevalence	NN
cord-023417-by18aczt	188	7	of	of	IN
cord-023417-by18aczt	188	8	H.	h.	NN
cord-023417-by18aczt	188	9	pylori	pylori	NN
cord-023417-by18aczt	188	10	infection	infection	NN
cord-023417-by18aczt	188	11	is	be	VBZ
cord-023417-by18aczt	188	12	the	the	DT
cord-023417-by18aczt	188	13	same	same	JJ
cord-023417-by18aczt	188	14	in	in	IN
cord-023417-by18aczt	188	15	ESRD	ESRD	NNP
cord-023417-by18aczt	188	16	patients	patient	NNS
cord-023417-by18aczt	188	17	as	as	IN
cord-023417-by18aczt	188	18	in	in	IN
cord-023417-by18aczt	188	19	healthy	healthy	JJ
cord-023417-by18aczt	188	20	individuals	individual	NNS
cord-023417-by18aczt	188	21	,	,	,
cord-023417-by18aczt	188	22	in	in	IN
cord-023417-by18aczt	188	23	our	-PRON-	PRP$
cord-023417-by18aczt	188	24	study	study	NN
cord-023417-by18aczt	188	25	that	that	WDT
cord-023417-by18aczt	188	26	seems	seem	VBZ
cord-023417-by18aczt	188	27	not	not	RB
cord-023417-by18aczt	188	28	to	to	TO
cord-023417-by18aczt	188	29	be	be	VB
cord-023417-by18aczt	188	30	the	the	DT
cord-023417-by18aczt	188	31	case	case	NN
cord-023417-by18aczt	188	32	.	.	.
cord-023417-by18aczt	189	1	The	the	DT
cord-023417-by18aczt	189	2	higher	high	JJR
cord-023417-by18aczt	189	3	blood	blood	NN
cord-023417-by18aczt	189	4	and	and	CC
cord-023417-by18aczt	189	5	gastric	gastric	JJ
cord-023417-by18aczt	189	6	juice	juice	NN
cord-023417-by18aczt	189	7	urea	urea	NN
cord-023417-by18aczt	189	8	levels	level	NNS
cord-023417-by18aczt	189	9	may	may	MD
cord-023417-by18aczt	189	10	be	be	VB
cord-023417-by18aczt	189	11	a	a	DT
cord-023417-by18aczt	189	12	risk	risk	NN
cord-023417-by18aczt	189	13	factor	factor	NN
cord-023417-by18aczt	189	14	(	(	-LRB-
cord-023417-by18aczt	189	15	among	among	IN
cord-023417-by18aczt	189	16	many	many	JJ
cord-023417-by18aczt	189	17	others	other	NNS
cord-023417-by18aczt	189	18	)	)	-RRB-
cord-023417-by18aczt	189	19	,	,	,
cord-023417-by18aczt	189	20	but	but	CC
cord-023417-by18aczt	189	21	more	more	JJR
cord-023417-by18aczt	189	22	studies	study	NNS
cord-023417-by18aczt	189	23	are	be	VBP
cord-023417-by18aczt	189	24	required	require	VBN
cord-023417-by18aczt	189	25	in	in	IN
cord-023417-by18aczt	189	26	order	order	NN
cord-023417-by18aczt	189	27	to	to	TO
cord-023417-by18aczt	189	28	understand	understand	VB
cord-023417-by18aczt	189	29	the	the	DT
cord-023417-by18aczt	189	30	relation	relation	NN
cord-023417-by18aczt	189	31	of	of	IN
cord-023417-by18aczt	189	32	H.	H.	NNP
cord-023417-by18aczt	189	33	pylori	pylori	NN
cord-023417-by18aczt	189	34	infection	infection	NN
cord-023417-by18aczt	189	35	in	in	IN
cord-023417-by18aczt	189	36	this	this	DT
cord-023417-by18aczt	189	37	group	group	NN
cord-023417-by18aczt	189	38	of	of	IN
cord-023417-by18aczt	189	39	patients	patient	NNS
cord-023417-by18aczt	189	40	.	.	.
cord-023417-by18aczt	190	1	Flanders	Flanders	NNP
cord-023417-by18aczt	190	2	Interuniversity	Interuniversity	NNP
cord-023417-by18aczt	190	3	Institute	Institute	NNP
cord-023417-by18aczt	190	4	for	for	IN
cord-023417-by18aczt	190	5	Biotechnology	Biotechnology	NNP
cord-023417-by18aczt	190	6	,	,	,
cord-023417-by18aczt	190	7	Department	Department	NNP
cord-023417-by18aczt	190	8	of	of	IN
cord-023417-by18aczt	190	9	Molecular	Molecular	NNP
cord-023417-by18aczt	190	10	and	and	CC
cord-023417-by18aczt	190	11	Cellular	Cellular	NNP
cord-023417-by18aczt	190	12	Interactions	Interactions	NNPS
cord-023417-by18aczt	190	13	,	,	,
cord-023417-by18aczt	190	14	Free	Free	NNP
cord-023417-by18aczt	190	15	University	University	NNP
cord-023417-by18aczt	190	16	of	of	IN
cord-023417-by18aczt	190	17	Brussels	Brussels	NNP
cord-023417-by18aczt	190	18	,	,	,
cord-023417-by18aczt	190	19	Brussels	Brussels	NNP
cord-023417-by18aczt	190	20	,	,	,
cord-023417-by18aczt	190	21	and	and	CC
cord-023417-by18aczt	190	22	2	2	CD
cord-023417-by18aczt	190	23	Pasteur	Pasteur	NNP
cord-023417-by18aczt	190	24	Institute	Institute	NNP
cord-023417-by18aczt	190	25	of	of	IN
cord-023417-by18aczt	190	26	Brussels	Brussels	NNP
cord-023417-by18aczt	190	27	,	,	,
cord-023417-by18aczt	190	28	Mycobacterial	Mycobacterial	NNP
cord-023417-by18aczt	190	29	Immunology	Immunology	NNP
cord-023417-by18aczt	190	30	,	,	,
cord-023417-by18aczt	190	31	Brussels	Brussels	NNP
cord-023417-by18aczt	190	32	,	,	,
cord-023417-by18aczt	190	33	Belgium	Belgium	NNP
cord-023417-by18aczt	190	34	.	.	.
cord-023417-by18aczt	191	1	E	e	NN
cord-023417-by18aczt	191	2	-	-	NN
cord-023417-by18aczt	191	3	mail	mail	NN
cord-023417-by18aczt	191	4	:	:	:
cord-023417-by18aczt	191	5	tgartner@vub.ac.be	tgartner@vub.ac.be	ADD
cord-023417-by18aczt	191	6	Immunity	immunity	NN
cord-023417-by18aczt	191	7	against	against	IN
cord-023417-by18aczt	191	8	tuberculosis	tuberculosis	NN
cord-023417-by18aczt	191	9	(	(	-LRB-
cord-023417-by18aczt	191	10	TB	TB	NNP
cord-023417-by18aczt	191	11	)	)	-RRB-
cord-023417-by18aczt	191	12	,	,	,
cord-023417-by18aczt	191	13	caused	cause	VBN
cord-023417-by18aczt	191	14	by	by	IN
cord-023417-by18aczt	191	15	Mycobacterium	Mycobacterium	NNP
cord-023417-by18aczt	191	16	tuberculosis	tuberculosis	NN
cord-023417-by18aczt	191	17	,	,	,
cord-023417-by18aczt	191	18	depends	depend	VBZ
cord-023417-by18aczt	191	19	largely	largely	RB
cord-023417-by18aczt	191	20	on	on	IN
cord-023417-by18aczt	191	21	activation	activation	NN
cord-023417-by18aczt	191	22	and	and	CC
cord-023417-by18aczt	191	23	maintenance	maintenance	NN
cord-023417-by18aczt	191	24	of	of	IN
cord-023417-by18aczt	191	25	strong	strong	JJ
cord-023417-by18aczt	191	26	cell	cell	NN
cord-023417-by18aczt	191	27	-	-	HYPH
cord-023417-by18aczt	191	28	mediated	mediate	VBN
cord-023417-by18aczt	191	29	immune	immune	JJ
cord-023417-by18aczt	191	30	responses	response	NNS
cord-023417-by18aczt	191	31	involving	involve	VBG
cord-023417-by18aczt	191	32	both	both	CC
cord-023417-by18aczt	191	33	CD4	CD4	NNP
cord-023417-by18aczt	191	34	þ	þ	NNP
cord-023417-by18aczt	191	35	and	and	CC
cord-023417-by18aczt	191	36	CD8	CD8	NNP
cord-023417-by18aczt	191	37	þ	þ	NNP
cord-023417-by18aczt	191	38	T	T	NNP
cord-023417-by18aczt	191	39	cells	cell	NNS
cord-023417-by18aczt	191	40	and	and	CC
cord-023417-by18aczt	191	41	the	the	DT
cord-023417-by18aczt	191	42	ability	ability	NN
cord-023417-by18aczt	191	43	to	to	TO
cord-023417-by18aczt	191	44	respond	respond	VB
cord-023417-by18aczt	191	45	with	with	IN
cord-023417-by18aczt	191	46	Th1-type	Th1-type	NNP
cord-023417-by18aczt	191	47	cytokines	cytokine	NNS
cord-023417-by18aczt	191	48	,	,	,
cord-023417-by18aczt	191	49	particularly	particularly	RB
cord-023417-by18aczt	191	50	IFN	IFN	NNP
cord-023417-by18aczt	191	51	-	-	HYPH
cord-023417-by18aczt	191	52	g	g	NNP
cord-023417-by18aczt	191	53	.	.	.
cord-023417-by18aczt	192	1	Recent	recent	JJ
cord-023417-by18aczt	192	2	studies	study	NNS
cord-023417-by18aczt	192	3	suggested	suggest	VBD
cord-023417-by18aczt	192	4	that	that	IN
cord-023417-by18aczt	192	5	BCG	BCG	NNP
cord-023417-by18aczt	192	6	,	,	,
cord-023417-by18aczt	192	7	the	the	DT
cord-023417-by18aczt	192	8	only	only	JJ
cord-023417-by18aczt	192	9	licensed	licensed	JJ
cord-023417-by18aczt	192	10	vaccine	vaccine	NN
cord-023417-by18aczt	192	11	against	against	IN
cord-023417-by18aczt	192	12	M.	M.	NNP
cord-023417-by18aczt	192	13	tuberculosis	tuberculosis	NN
cord-023417-by18aczt	192	14	,	,	,
cord-023417-by18aczt	192	15	may	may	MD
cord-023417-by18aczt	192	16	fail	fail	VB
cord-023417-by18aczt	192	17	to	to	TO
cord-023417-by18aczt	192	18	induce	induce	VB
cord-023417-by18aczt	192	19	T	t	NN
cord-023417-by18aczt	192	20	-	-	HYPH
cord-023417-by18aczt	192	21	cell	cell	NN
cord-023417-by18aczt	192	22	responses	response	NNS
cord-023417-by18aczt	192	23	in	in	IN
cord-023417-by18aczt	192	24	the	the	DT
cord-023417-by18aczt	192	25	lung	lung	NN
cord-023417-by18aczt	192	26	mucosa	mucosa	NN
cord-023417-by18aczt	192	27	and	and	CC
cord-023417-by18aczt	192	28	may	may	MD
cord-023417-by18aczt	192	29	therefore	therefore	RB
cord-023417-by18aczt	192	30	not	not	RB
cord-023417-by18aczt	192	31	protect	protect	VB
cord-023417-by18aczt	192	32	against	against	IN
cord-023417-by18aczt	192	33	pulmonary	pulmonary	JJ
cord-023417-by18aczt	192	34	TB	tb	NN
cord-023417-by18aczt	192	35	.	.	.
cord-023417-by18aczt	193	1	A	a	DT
cord-023417-by18aczt	193	2	decrease	decrease	NN
cord-023417-by18aczt	193	3	in	in	IN
cord-023417-by18aczt	193	4	TB	TB	NNP
cord-023417-by18aczt	193	5	mortality	mortality	NN
cord-023417-by18aczt	193	6	may	may	MD
cord-023417-by18aczt	193	7	be	be	VB
cord-023417-by18aczt	193	8	achieved	achieve	VBN
cord-023417-by18aczt	193	9	by	by	IN
cord-023417-by18aczt	193	10	enhancing	enhance	VBG
cord-023417-by18aczt	193	11	immunity	immunity	NN
cord-023417-by18aczt	193	12	in	in	IN
cord-023417-by18aczt	193	13	the	the	DT
cord-023417-by18aczt	193	14	lung	lung	NN
cord-023417-by18aczt	193	15	.	.	.
cord-023417-by18aczt	194	1	The	the	DT
cord-023417-by18aczt	194	2	present	present	JJ
cord-023417-by18aczt	194	3	study	study	NN
cord-023417-by18aczt	194	4	evaluated	evaluate	VBD
cord-023417-by18aczt	194	5	the	the	DT
cord-023417-by18aczt	194	6	induction	induction	NN
cord-023417-by18aczt	194	7	of	of	IN
cord-023417-by18aczt	194	8	antigen	antigen	NN
cord-023417-by18aczt	194	9	-	-	HYPH
cord-023417-by18aczt	194	10	specific	specific	JJ
cord-023417-by18aczt	194	11	immunity	immunity	NN
cord-023417-by18aczt	194	12	in	in	IN
cord-023417-by18aczt	194	13	the	the	DT
cord-023417-by18aczt	194	14	lung	lung	NN
cord-023417-by18aczt	194	15	by	by	IN
cord-023417-by18aczt	194	16	intranasal	intranasal	NN
cord-023417-by18aczt	194	17	(	(	-LRB-
cord-023417-by18aczt	194	18	i.n	i.n	NNP
cord-023417-by18aczt	194	19	.	.	NNP
cord-023417-by18aczt	194	20	)	)	-RRB-
cord-023417-by18aczt	194	21	delivery	delivery	NN
cord-023417-by18aczt	194	22	of	of	IN
cord-023417-by18aczt	194	23	the	the	DT
cord-023417-by18aczt	194	24	lipoprotein	lipoprotein	NN
cord-023417-by18aczt	195	1	I	-PRON-	PRP
cord-023417-by18aczt	195	2	(	(	-LRB-
cord-023417-by18aczt	195	3	OprI	OprI	NNP
cord-023417-by18aczt	195	4	)	)	-RRB-
cord-023417-by18aczt	195	5	from	from	IN
cord-023417-by18aczt	195	6	Pseudomonas	Pseudomonas	NNP
cord-023417-by18aczt	195	7	aeruginosa	aeruginosa	NN
cord-023417-by18aczt	195	8	.	.	.
cord-023417-by18aczt	196	1	OprI	OprI	NNP
cord-023417-by18aczt	196	2	has	have	VBZ
cord-023417-by18aczt	196	3	shown	show	VBN
cord-023417-by18aczt	196	4	to	to	TO
cord-023417-by18aczt	196	5	be	be	VB
cord-023417-by18aczt	196	6	a	a	DT
cord-023417-by18aczt	196	7	Toll	toll	NN
cord-023417-by18aczt	196	8	-	-	HYPH
cord-023417-by18aczt	196	9	like	like	JJ
cord-023417-by18aczt	196	10	receptor	receptor	NN
cord-023417-by18aczt	196	11	2/4	2/4	CD
cord-023417-by18aczt	196	12	agonist	agonist	NN
cord-023417-by18aczt	196	13	that	that	WDT
cord-023417-by18aczt	196	14	,	,	,
cord-023417-by18aczt	196	15	when	when	WRB
cord-023417-by18aczt	196	16	given	give	VBN
cord-023417-by18aczt	196	17	subcutaneously	subcutaneously	RB
cord-023417-by18aczt	196	18	,	,	,
cord-023417-by18aczt	196	19	induces	induce	VBZ
cord-023417-by18aczt	196	20	Type-1	type-1	NN
cord-023417-by18aczt	196	21	immune	immune	JJ
cord-023417-by18aczt	196	22	responses	response	NNS
cord-023417-by18aczt	196	23	against	against	IN
cord-023417-by18aczt	196	24	heterologous	heterologous	JJ
cord-023417-by18aczt	196	25	antigens	antigen	NNS
cord-023417-by18aczt	196	26	.	.	.
cord-023417-by18aczt	197	1	Here	here	RB
cord-023417-by18aczt	197	2	,	,	,
cord-023417-by18aczt	197	3	a	a	DT
cord-023417-by18aczt	197	4	fusion	fusion	NN
cord-023417-by18aczt	197	5	of	of	IN
cord-023417-by18aczt	197	6	OprI	OprI	NNP
cord-023417-by18aczt	197	7	to	to	TO
cord-023417-by18aczt	197	8	Ag85A	Ag85A	NNP
cord-023417-by18aczt	197	9	of	of	IN
cord-023417-by18aczt	197	10	Mtb	Mtb	NNP
cord-023417-by18aczt	197	11	(	(	-LRB-
cord-023417-by18aczt	197	12	OprI	OprI	NNP
cord-023417-by18aczt	197	13	-	-	HYPH
cord-023417-by18aczt	197	14	Ag85A	Ag85A	NNP
cord-023417-by18aczt	197	15	)	)	-RRB-
cord-023417-by18aczt	197	16	was	be	VBD
cord-023417-by18aczt	197	17	used	use	VBN
cord-023417-by18aczt	197	18	as	as	IN
cord-023417-by18aczt	197	19	a	a	DT
cord-023417-by18aczt	197	20	subunit	subunit	NN
cord-023417-by18aczt	197	21	vaccine	vaccine	NN
cord-023417-by18aczt	197	22	in	in	IN
cord-023417-by18aczt	197	23	homologous	homologous	JJ
cord-023417-by18aczt	197	24	prime	prime	JJ
cord-023417-by18aczt	197	25	-	-	HYPH
cord-023417-by18aczt	197	26	boost	boost	NN
cord-023417-by18aczt	197	27	immunizations	immunization	NNS
cord-023417-by18aczt	197	28	.	.	.
cord-023417-by18aczt	198	1	In	in	IN
cord-023417-by18aczt	198	2	addition	addition	NN
cord-023417-by18aczt	198	3	,	,	,
cord-023417-by18aczt	198	4	OprI	OprI	NNP
cord-023417-by18aczt	198	5	-	-	HYPH
cord-023417-by18aczt	198	6	Ag85A	Ag85A	NNP
cord-023417-by18aczt	198	7	was	be	VBD
cord-023417-by18aczt	198	8	combined	combine	VBN
cord-023417-by18aczt	198	9	with	with	IN
cord-023417-by18aczt	198	10	an	an	DT
cord-023417-by18aczt	198	11	Ag85A	ag85a	NN
cord-023417-by18aczt	198	12	-	-	HYPH
cord-023417-by18aczt	198	13	encoding	encode	VBG
cord-023417-by18aczt	198	14	DNA	dna	NN
cord-023417-by18aczt	198	15	vaccine	vaccine	NN
cord-023417-by18aczt	198	16	(	(	-LRB-
cord-023417-by18aczt	198	17	Ag85A	Ag85A	NNP
cord-023417-by18aczt	198	18	DNA	DNA	NNP
cord-023417-by18aczt	198	19	)	)	-RRB-
cord-023417-by18aczt	198	20	or	or	CC
cord-023417-by18aczt	198	21	with	with	IN
cord-023417-by18aczt	198	22	BCG	BCG	NNP
cord-023417-by18aczt	198	23	in	in	IN
cord-023417-by18aczt	198	24	heterologous	heterologous	JJ
cord-023417-by18aczt	198	25	prime	prime	JJ
cord-023417-by18aczt	198	26	-	-	HYPH
cord-023417-by18aczt	198	27	boost	boost	NN
cord-023417-by18aczt	198	28	vaccinations	vaccination	NNS
cord-023417-by18aczt	198	29	.	.	.
cord-023417-by18aczt	199	1	Intranasal	intranasal	NN
cord-023417-by18aczt	199	2	and	and	CC
cord-023417-by18aczt	199	3	parenteral	parenteral	JJ
cord-023417-by18aczt	199	4	delivery	delivery	NN
cord-023417-by18aczt	199	5	with	with	IN
cord-023417-by18aczt	199	6	OprI	OprI	NNP
cord-023417-by18aczt	199	7	-	-	HYPH
cord-023417-by18aczt	199	8	Ag85A	Ag85A	NNP
cord-023417-by18aczt	199	9	elicited	elicit	VBD
cord-023417-by18aczt	199	10	comparable	comparable	JJ
cord-023417-by18aczt	199	11	T	t	NN
cord-023417-by18aczt	199	12	-	-	HYPH
cord-023417-by18aczt	199	13	cell	cell	NN
cord-023417-by18aczt	199	14	responses	response	NNS
cord-023417-by18aczt	199	15	in	in	IN
cord-023417-by18aczt	199	16	the	the	DT
cord-023417-by18aczt	199	17	spleen	spleen	NN
cord-023417-by18aczt	199	18	;	;	:
cord-023417-by18aczt	199	19	in	in	IN
cord-023417-by18aczt	199	20	addition	addition	NN
cord-023417-by18aczt	199	21	,	,	,
cord-023417-by18aczt	199	22	i.n	i.n	NNP
cord-023417-by18aczt	199	23	.	.	NNP
cord-023417-by18aczt	199	24	delivery	delivery	NN
cord-023417-by18aczt	199	25	elicited	elicit	VBD
cord-023417-by18aczt	199	26	specific	specific	JJ
cord-023417-by18aczt	199	27	T	t	NN
cord-023417-by18aczt	199	28	-	-	HYPH
cord-023417-by18aczt	199	29	cell	cell	NN
cord-023417-by18aczt	199	30	responses	response	NNS
cord-023417-by18aczt	199	31	in	in	IN
cord-023417-by18aczt	199	32	the	the	DT
cord-023417-by18aczt	199	33	lung	lung	NN
cord-023417-by18aczt	199	34	lymph	lymph	NN
cord-023417-by18aczt	199	35	nodes	node	NNS
cord-023417-by18aczt	199	36	(	(	-LRB-
cord-023417-by18aczt	199	37	LLNs	lln	NNS
cord-023417-by18aczt	199	38	)	)	-RRB-
cord-023417-by18aczt	199	39	.	.	.
cord-023417-by18aczt	200	1	Intramuscular	intramuscular	JJ
cord-023417-by18aczt	200	2	delivery	delivery	NN
cord-023417-by18aczt	200	3	of	of	IN
cord-023417-by18aczt	200	4	Ag85A	Ag85A	NNP
cord-023417-by18aczt	200	5	DNA	DNA	NNP
cord-023417-by18aczt	200	6	induced	induce	VBD
cord-023417-by18aczt	200	7	significant	significant	JJ
cord-023417-by18aczt	200	8	systemic	systemic	JJ
cord-023417-by18aczt	200	9	Th1	th1	CD
cord-023417-by18aczt	200	10	immune	immune	JJ
cord-023417-by18aczt	200	11	responses	response	NNS
cord-023417-by18aczt	200	12	.	.	.
cord-023417-by18aczt	201	1	Intranasal	intranasal	NN
cord-023417-by18aczt	201	2	boosting	boost	VBG
cord-023417-by18aczt	201	3	with	with	IN
cord-023417-by18aczt	201	4	OprI	OprI	NNP
cord-023417-by18aczt	201	5	-	-	HYPH
cord-023417-by18aczt	201	6	Ag85A	Ag85A	NNP
cord-023417-by18aczt	201	7	enhanced	enhance	VBD
cord-023417-by18aczt	201	8	this	this	DT
cord-023417-by18aczt	201	9	response	response	NN
cord-023417-by18aczt	201	10	and	and	CC
cord-023417-by18aczt	201	11	in	in	IN
cord-023417-by18aczt	201	12	addition	addition	NN
cord-023417-by18aczt	201	13	induced	induce	VBD
cord-023417-by18aczt	201	14	an	an	DT
cord-023417-by18aczt	201	15	antigen	antigen	NN
cord-023417-by18aczt	201	16	-	-	HYPH
cord-023417-by18aczt	201	17	specific	specific	JJ
cord-023417-by18aczt	201	18	IFN	IFN	NNP
cord-023417-by18aczt	201	19	-	-	HYPH
cord-023417-by18aczt	201	20	g	g	NN
cord-023417-by18aczt	201	21	response	response	NN
cord-023417-by18aczt	201	22	in	in	IN
cord-023417-by18aczt	201	23	LLN	LLN	NNP
cord-023417-by18aczt	201	24	.	.	.
cord-023417-by18aczt	202	1	OprI	OprI	NNP
cord-023417-by18aczt	202	2	may	may	MD
cord-023417-by18aczt	202	3	therefore	therefore	RB
cord-023417-by18aczt	202	4	be	be	VB
cord-023417-by18aczt	202	5	an	an	DT
cord-023417-by18aczt	202	6	efficient	efficient	JJ
cord-023417-by18aczt	202	7	adjuvant	adjuvant	NN
cord-023417-by18aczt	202	8	for	for	IN
cord-023417-by18aczt	202	9	mucosal	mucosal	JJ
cord-023417-by18aczt	202	10	boosting	boosting	NN
cord-023417-by18aczt	202	11	.	.	.
cord-023417-by18aczt	203	1	We	-PRON-	PRP
cord-023417-by18aczt	203	2	continue	continue	VBP
cord-023417-by18aczt	203	3	to	to	TO
cord-023417-by18aczt	203	4	evaluate	evaluate	VB
cord-023417-by18aczt	203	5	the	the	DT
cord-023417-by18aczt	203	6	protection	protection	NN
cord-023417-by18aczt	203	7	induced	induce	VBN
cord-023417-by18aczt	203	8	by	by	IN
cord-023417-by18aczt	203	9	OprI	OprI	NNP
cord-023417-by18aczt	203	10	-	-	HYPH
cord-023417-by18aczt	203	11	based	base	VBN
cord-023417-by18aczt	203	12	prime	prime	JJ
cord-023417-by18aczt	203	13	-	-	HYPH
cord-023417-by18aczt	203	14	boost	boost	NN
cord-023417-by18aczt	203	15	vaccinations	vaccination	NNS
cord-023417-by18aczt	203	16	against	against	IN
cord-023417-by18aczt	203	17	pulmonary	pulmonary	JJ
cord-023417-by18aczt	203	18	TB	TB	NNP
cord-023417-by18aczt	203	19	.	.	.
cord-023417-by18aczt	204	1	Results	result	NNS
cord-023417-by18aczt	204	2	on	on	IN
cord-023417-by18aczt	204	3	the	the	DT
cord-023417-by18aczt	204	4	immunogenicity	immunogenicity	NN
cord-023417-by18aczt	204	5	and	and	CC
cord-023417-by18aczt	204	6	protection	protection	NN
cord-023417-by18aczt	204	7	against	against	IN
cord-023417-by18aczt	204	8	intravenous	intravenous	JJ
cord-023417-by18aczt	204	9	Mtb	Mtb	NNP
cord-023417-by18aczt	204	10	H37Rv	H37Rv	NNP
cord-023417-by18aczt	204	11	infection	infection	NN
cord-023417-by18aczt	204	12	will	will	MD
cord-023417-by18aczt	204	13	be	be	VB
cord-023417-by18aczt	204	14	presented	present	VBN
cord-023417-by18aczt	204	15	.	.	.
cord-023417-by18aczt	205	1	Toll	toll	NN
cord-023417-by18aczt	205	2	-	-	HYPH
cord-023417-by18aczt	205	3	like	like	JJ
cord-023417-by18aczt	205	4	receptors	receptor	NNS
cord-023417-by18aczt	205	5	(	(	-LRB-
cord-023417-by18aczt	205	6	TLRs	TLRs	NNP
cord-023417-by18aczt	205	7	)	)	-RRB-
cord-023417-by18aczt	205	8	are	be	VBP
cord-023417-by18aczt	205	9	pattern	pattern	NN
cord-023417-by18aczt	205	10	recognition	recognition	NN
cord-023417-by18aczt	205	11	receptors	receptor	NNS
cord-023417-by18aczt	205	12	of	of	IN
cord-023417-by18aczt	205	13	the	the	DT
cord-023417-by18aczt	205	14	innate	innate	JJ
cord-023417-by18aczt	205	15	immune	immune	JJ
cord-023417-by18aczt	205	16	system	system	NN
cord-023417-by18aczt	205	17	,	,	,
cord-023417-by18aczt	205	18	which	which	WDT
cord-023417-by18aczt	205	19	recognize	recognize	VBP
cord-023417-by18aczt	205	20	molecular	molecular	JJ
cord-023417-by18aczt	205	21	structures	structure	NNS
cord-023417-by18aczt	205	22	on	on	IN
cord-023417-by18aczt	205	23	pathogens	pathogen	NNS
cord-023417-by18aczt	205	24	or	or	CC
cord-023417-by18aczt	205	25	cellular	cellular	JJ
cord-023417-by18aczt	205	26	stress	stress	NN
cord-023417-by18aczt	205	27	-	-	HYPH
cord-023417-by18aczt	205	28	associated	associate	VBN
cord-023417-by18aczt	205	29	molecules	molecule	NNS
cord-023417-by18aczt	205	30	.	.	.
cord-023417-by18aczt	206	1	TLR	TLR	NNP
cord-023417-by18aczt	206	2	-	-	HYPH
cord-023417-by18aczt	206	3	ligand	ligand	NN
cord-023417-by18aczt	206	4	interactions	interaction	NNS
cord-023417-by18aczt	206	5	trigger	trigger	VBP
cord-023417-by18aczt	206	6	activation	activation	NN
cord-023417-by18aczt	206	7	of	of	IN
cord-023417-by18aczt	206	8	inflammatory	inflammatory	JJ
cord-023417-by18aczt	206	9	signal	signal	NN
cord-023417-by18aczt	206	10	transduction	transduction	NN
cord-023417-by18aczt	206	11	and	and	CC
cord-023417-by18aczt	206	12	expression	expression	NN
cord-023417-by18aczt	206	13	of	of	IN
cord-023417-by18aczt	206	14	genes	gene	NNS
cord-023417-by18aczt	206	15	involved	involve	VBN
cord-023417-by18aczt	206	16	in	in	IN
cord-023417-by18aczt	206	17	host	host	NN
cord-023417-by18aczt	206	18	defense	defense	NN
cord-023417-by18aczt	206	19	.	.	.
cord-023417-by18aczt	207	1	In	in	IN
cord-023417-by18aczt	207	2	this	this	DT
cord-023417-by18aczt	207	3	study	study	NN
cord-023417-by18aczt	207	4	,	,	,
cord-023417-by18aczt	207	5	we	-PRON-	PRP
cord-023417-by18aczt	207	6	have	have	VBP
cord-023417-by18aczt	207	7	examined	examine	VBN
cord-023417-by18aczt	207	8	the	the	DT
cord-023417-by18aczt	207	9	requirement	requirement	NN
cord-023417-by18aczt	207	10	for	for	IN
cord-023417-by18aczt	207	11	different	different	JJ
cord-023417-by18aczt	207	12	TLR	TLR	NNP
cord-023417-by18aczt	207	13	adaptor	adaptor	NN
cord-023417-by18aczt	207	14	molecules	molecule	NNS
cord-023417-by18aczt	207	15	in	in	IN
cord-023417-by18aczt	207	16	virus	virus	NN
cord-023417-by18aczt	207	17	-	-	HYPH
cord-023417-by18aczt	207	18	induced	induce	VBN
cord-023417-by18aczt	207	19	chemokine	chemokine	NN
cord-023417-by18aczt	207	20	expression	expression	NN
cord-023417-by18aczt	207	21	and	and	CC
cord-023417-by18aczt	207	22	are	be	VBP
cord-023417-by18aczt	207	23	currently	currently	RB
cord-023417-by18aczt	207	24	trying	try	VBG
cord-023417-by18aczt	207	25	to	to	TO
cord-023417-by18aczt	207	26	identify	identify	VB
cord-023417-by18aczt	207	27	the	the	DT
cord-023417-by18aczt	207	28	TLR	TLR	NNP
cord-023417-by18aczt	207	29	involved	involve	VBN
cord-023417-by18aczt	207	30	.	.	.
cord-023417-by18aczt	208	1	We	-PRON-	PRP
cord-023417-by18aczt	208	2	have	have	VBP
cord-023417-by18aczt	208	3	found	find	VBN
cord-023417-by18aczt	208	4	that	that	IN
cord-023417-by18aczt	208	5	both	both	CC
cord-023417-by18aczt	208	6	a	a	DT
cord-023417-by18aczt	208	7	herpesvirus	herpesvirus	NN
cord-023417-by18aczt	208	8	[	[	-LRB-
cord-023417-by18aczt	208	9	herpes	herpes	NN
cord-023417-by18aczt	208	10	simplex	simplex	NN
cord-023417-by18aczt	208	11	virus	virus	NN
cord-023417-by18aczt	208	12	(	(	-LRB-
cord-023417-by18aczt	208	13	HSV	HSV	NNP
cord-023417-by18aczt	208	14	)	)	-RRB-
cord-023417-by18aczt	208	15	]	]	-RRB-
cord-023417-by18aczt	208	16	and	and	CC
cord-023417-by18aczt	208	17	a	a	DT
cord-023417-by18aczt	208	18	paramyxovirus	paramyxovirus	JJ
cord-023417-by18aczt	208	19	(	(	-LRB-
cord-023417-by18aczt	208	20	Sendai	Sendai	NNP
cord-023417-by18aczt	208	21	virus	virus	NN
cord-023417-by18aczt	208	22	)	)	-RRB-
cord-023417-by18aczt	208	23	require	require	VBP
cord-023417-by18aczt	208	24	a	a	DT
cord-023417-by18aczt	208	25	functional	functional	JJ
cord-023417-by18aczt	208	26	genome	genome	NN
cord-023417-by18aczt	208	27	to	to	TO
cord-023417-by18aczt	208	28	induce	induce	VB
cord-023417-by18aczt	208	29	expression	expression	NN
cord-023417-by18aczt	208	30	or	or	CC
cord-023417-by18aczt	208	31	proinflammatory	proinflammatory	JJ
cord-023417-by18aczt	208	32	chemokines	chemokine	NNS
cord-023417-by18aczt	208	33	in	in	IN
cord-023417-by18aczt	208	34	human	human	JJ
cord-023417-by18aczt	208	35	and	and	CC
cord-023417-by18aczt	208	36	murine	murine	JJ
cord-023417-by18aczt	208	37	monocytic	monocytic	JJ
cord-023417-by18aczt	208	38	cell	cell	NN
cord-023417-by18aczt	208	39	lines	line	NNS
cord-023417-by18aczt	208	40	.	.	.
cord-023417-by18aczt	209	1	For	for	IN
cord-023417-by18aczt	209	2	both	both	DT
cord-023417-by18aczt	209	3	viruses	virus	NNS
cord-023417-by18aczt	209	4	,	,	,
cord-023417-by18aczt	209	5	this	this	DT
cord-023417-by18aczt	209	6	is	be	VBZ
cord-023417-by18aczt	209	7	independent	independent	JJ
cord-023417-by18aczt	209	8	of	of	IN
cord-023417-by18aczt	209	9	the	the	DT
cord-023417-by18aczt	209	10	TLR	TLR	NNP
cord-023417-by18aczt	209	11	adaptor	adaptor	NN
cord-023417-by18aczt	209	12	molecules	molecule	NNS
cord-023417-by18aczt	210	1	TRIF	TRIF	NNP
cord-023417-by18aczt	210	2	and	and	CC
cord-023417-by18aczt	210	3	Mal	Mal	NNP
cord-023417-by18aczt	210	4	.	.	.
cord-023417-by18aczt	211	1	However	however	RB
cord-023417-by18aczt	211	2	,	,	,
cord-023417-by18aczt	211	3	overexpression	overexpression	NN
cord-023417-by18aczt	211	4	of	of	IN
cord-023417-by18aczt	211	5	the	the	DT
cord-023417-by18aczt	211	6	Vaccinia	Vaccinia	NNP
cord-023417-by18aczt	211	7	virus	virus	NN
cord-023417-by18aczt	211	8	-	-	HYPH
cord-023417-by18aczt	211	9	encoded	encode	VBN
cord-023417-by18aczt	211	10	inhibitor	inhibitor	NN
cord-023417-by18aczt	211	11	of	of	IN
cord-023417-by18aczt	211	12	TLR	TLR	NNP
cord-023417-by18aczt	211	13	-	-	HYPH
cord-023417-by18aczt	211	14	signalling	signal	VBG
cord-023417-by18aczt	211	15	A52R	a52r	NN
cord-023417-by18aczt	211	16	or	or	CC
cord-023417-by18aczt	211	17	dominant	dominant	JJ
cord-023417-by18aczt	211	18	-	-	HYPH
cord-023417-by18aczt	211	19	negative	negative	JJ
cord-023417-by18aczt	211	20	MyD88	MyD88	NNS
cord-023417-by18aczt	211	21	totally	totally	RB
cord-023417-by18aczt	211	22	inhibited	inhibited	JJ
cord-023417-by18aczt	211	23	HSV	HSV	NNP
cord-023417-by18aczt	211	24	-	-	HYPH
cord-023417-by18aczt	211	25	induced	induce	VBN
cord-023417-by18aczt	211	26	RANTES	RANTES	NNP
cord-023417-by18aczt	211	27	expression	expression	NN
cord-023417-by18aczt	211	28	but	but	CC
cord-023417-by18aczt	211	29	only	only	RB
cord-023417-by18aczt	211	30	partially	partially	RB
cord-023417-by18aczt	211	31	prevented	prevent	VBD
cord-023417-by18aczt	211	32	Sendai	Sendai	NNP
cord-023417-by18aczt	211	33	virus	virus	NN
cord-023417-by18aczt	211	34	from	from	IN
cord-023417-by18aczt	211	35	inducing	induce	VBG
cord-023417-by18aczt	211	36	this	this	DT
cord-023417-by18aczt	211	37	chemokine	chemokine	NN
cord-023417-by18aczt	211	38	.	.	.
cord-023417-by18aczt	212	1	This	this	DT
cord-023417-by18aczt	212	2	suggests	suggest	VBZ
cord-023417-by18aczt	212	3	that	that	IN
cord-023417-by18aczt	212	4	HSV	HSV	NNP
cord-023417-by18aczt	212	5	-	-	HYPH
cord-023417-by18aczt	212	6	induced	induce	VBN
cord-023417-by18aczt	212	7	RANTES	RANTES	NNP
cord-023417-by18aczt	212	8	expression	expression	NN
cord-023417-by18aczt	212	9	occurs	occur	VBZ
cord-023417-by18aczt	212	10	via	via	IN
cord-023417-by18aczt	212	11	a	a	DT
cord-023417-by18aczt	212	12	TLR	TLR	NNP
cord-023417-by18aczt	212	13	pathways	pathway	NNS
cord-023417-by18aczt	212	14	,	,	,
cord-023417-by18aczt	212	15	whereas	whereas	IN
cord-023417-by18aczt	212	16	Sendai	Sendai	NNP
cord-023417-by18aczt	212	17	virus	virus	NN
cord-023417-by18aczt	212	18	utilizes	utilize	VBZ
cord-023417-by18aczt	212	19	both	both	DT
cord-023417-by18aczt	212	20	TLR	TLR	NNP
cord-023417-by18aczt	212	21	-	-	HYPH
cord-023417-by18aczt	212	22	dependent	dependent	JJ
cord-023417-by18aczt	212	23	and	and	CC
cord-023417-by18aczt	212	24	-independent	-independent	JJ
cord-023417-by18aczt	212	25	pathways	pathway	NNS
cord-023417-by18aczt	212	26	to	to	TO
cord-023417-by18aczt	212	27	stimulate	stimulate	VB
cord-023417-by18aczt	212	28	expression	expression	NN
cord-023417-by18aczt	212	29	of	of	IN
cord-023417-by18aczt	212	30	RANTES	rante	NNS
cord-023417-by18aczt	212	31	.	.	.
cord-023417-by18aczt	213	1	We	-PRON-	PRP
cord-023417-by18aczt	213	2	are	be	VBP
cord-023417-by18aczt	213	3	currently	currently	RB
cord-023417-by18aczt	213	4	trying	try	VBG
cord-023417-by18aczt	213	5	to	to	TO
cord-023417-by18aczt	213	6	identify	identify	VB
cord-023417-by18aczt	213	7	the	the	DT
cord-023417-by18aczt	213	8	TLRs	tlr	NNS
cord-023417-by18aczt	213	9	involved	involve	VBN
cord-023417-by18aczt	213	10	.	.	.
cord-023417-by18aczt	214	1	Data	datum	NNS
cord-023417-by18aczt	214	2	from	from	IN
cord-023417-by18aczt	214	3	these	these	DT
cord-023417-by18aczt	214	4	studies	study	NNS
cord-023417-by18aczt	214	5	will	will	MD
cord-023417-by18aczt	214	6	also	also	RB
cord-023417-by18aczt	214	7	be	be	VB
cord-023417-by18aczt	214	8	presented	present	VBN
cord-023417-by18aczt	214	9	at	at	IN
cord-023417-by18aczt	214	10	the	the	DT
cord-023417-by18aczt	214	11	meeting	meeting	NN
cord-023417-by18aczt	214	12	.	.	.
cord-023417-by18aczt	215	1	2	2	LS
cord-023417-by18aczt	215	2	0	0	CD
cord-023417-by18aczt	215	3	-5	-5	CD
cord-023417-by18aczt	215	4	0	0	CD
cord-023417-by18aczt	216	1	-oligoadenylate	-oligoadenylate	.
cord-023417-by18aczt	217	1	synthetases	synthetase	NNS
cord-023417-by18aczt	217	2	are	be	VBP
cord-023417-by18aczt	217	3	interferon	interferon	NN
cord-023417-by18aczt	217	4	-	-	HYPH
cord-023417-by18aczt	217	5	induced	induce	VBN
cord-023417-by18aczt	217	6	,	,	,
cord-023417-by18aczt	217	7	double	double	RB
cord-023417-by18aczt	217	8	-	-	HYPH
cord-023417-by18aczt	217	9	stranded	strand	VBN
cord-023417-by18aczt	217	10	RNA	RNA	NNP
cord-023417-by18aczt	217	11	-	-	HYPH
cord-023417-by18aczt	217	12	activated	activate	VBN
cord-023417-by18aczt	217	13	antiviral	antiviral	JJ
cord-023417-by18aczt	217	14	enzymes	enzyme	NNS
cord-023417-by18aczt	217	15	which	which	WDT
cord-023417-by18aczt	217	16	are	be	VBP
cord-023417-by18aczt	217	17	the	the	DT
cord-023417-by18aczt	217	18	only	only	JJ
cord-023417-by18aczt	217	19	proteins	protein	NNS
cord-023417-by18aczt	217	20	known	know	VBN
cord-023417-by18aczt	217	21	to	to	TO
cord-023417-by18aczt	217	22	catalyse	catalyse	VB
cord-023417-by18aczt	217	23	2	2	CD
cord-023417-by18aczt	217	24	0	0	CD
cord-023417-by18aczt	217	25	-specific	-specific	NN
cord-023417-by18aczt	217	26	nucleotidyl	nucleotidyl	NN
cord-023417-by18aczt	217	27	transfer	transfer	NN
cord-023417-by18aczt	217	28	.	.	.
cord-023417-by18aczt	218	1	This	this	DT
cord-023417-by18aczt	218	2	first	first	JJ
cord-023417-by18aczt	218	3	crystal	crystal	NN
cord-023417-by18aczt	218	4	structure	structure	NN
cord-023417-by18aczt	218	5	of	of	IN
cord-023417-by18aczt	218	6	a	a	DT
cord-023417-by18aczt	218	7	2	2	CD
cord-023417-by18aczt	218	8	0	0	CD
cord-023417-by18aczt	218	9	-5	-5	CD
cord-023417-by18aczt	218	10	0oligoadenylate	0oligoadenylate	CD
cord-023417-by18aczt	218	11	synthetase	synthetase	NNP
cord-023417-by18aczt	218	12	reveals	reveal	VBZ
cord-023417-by18aczt	218	13	a	a	DT
cord-023417-by18aczt	218	14	structural	structural	JJ
cord-023417-by18aczt	218	15	conservation	conservation	NN
cord-023417-by18aczt	218	16	with	with	IN
cord-023417-by18aczt	218	17	the	the	DT
cord-023417-by18aczt	218	18	3	3	CD
cord-023417-by18aczt	218	19	0	0	CD
cord-023417-by18aczt	218	20	-specific	-specific	NN
cord-023417-by18aczt	218	21	poly(A	poly(A	NNP
cord-023417-by18aczt	218	22	)	)	-RRB-
cord-023417-by18aczt	218	23	polymerase	polymerase	NN
cord-023417-by18aczt	218	24	that	that	WDT
cord-023417-by18aczt	218	25	,	,	,
cord-023417-by18aczt	218	26	coupled	couple	VBN
cord-023417-by18aczt	218	27	with	with	IN
cord-023417-by18aczt	218	28	structure	structure	NN
cord-023417-by18aczt	218	29	-	-	HYPH
cord-023417-by18aczt	218	30	guided	guide	VBN
cord-023417-by18aczt	218	31	mutagenesis	mutagenesis	NN
cord-023417-by18aczt	218	32	,	,	,
cord-023417-by18aczt	218	33	supports	support	VBZ
cord-023417-by18aczt	218	34	a	a	DT
cord-023417-by18aczt	218	35	conserved	conserved	JJ
cord-023417-by18aczt	218	36	catalytic	catalytic	JJ
cord-023417-by18aczt	218	37	mechanism	mechanism	NN
cord-023417-by18aczt	218	38	for	for	IN
cord-023417-by18aczt	218	39	the	the	DT
cord-023417-by18aczt	218	40	2	2	CD
cord-023417-by18aczt	218	41	0	0	CD
cord-023417-by18aczt	218	42	-and	-and	SYM
cord-023417-by18aczt	218	43	3	3	CD
cord-023417-by18aczt	218	44	0	0	CD
cord-023417-by18aczt	218	45	-specific	-specific	HYPH
cord-023417-by18aczt	218	46	nucleotidyl	nucleotidyl	NN
cord-023417-by18aczt	218	47	transferases	transferase	NNS
cord-023417-by18aczt	218	48	.	.	.
cord-023417-by18aczt	219	1	Comparison	comparison	NN
cord-023417-by18aczt	219	2	with	with	IN
cord-023417-by18aczt	219	3	structures	structure	NNS
cord-023417-by18aczt	219	4	of	of	IN
cord-023417-by18aczt	219	5	other	other	JJ
cord-023417-by18aczt	219	6	superfamily	superfamily	NN
cord-023417-by18aczt	219	7	members	member	NNS
cord-023417-by18aczt	219	8	indicates	indicate	VBZ
cord-023417-by18aczt	219	9	that	that	IN
cord-023417-by18aczt	219	10	the	the	DT
cord-023417-by18aczt	219	11	donor	donor	NN
cord-023417-by18aczt	219	12	substrates	substrate	NNS
cord-023417-by18aczt	219	13	are	be	VBP
cord-023417-by18aczt	219	14	bound	bind	VBN
cord-023417-by18aczt	219	15	by	by	IN
cord-023417-by18aczt	219	16	conserved	conserve	VBN
cord-023417-by18aczt	219	17	active	active	JJ
cord-023417-by18aczt	219	18	site	site	NN
cord-023417-by18aczt	219	19	features	feature	NNS
cord-023417-by18aczt	219	20	while	while	IN
cord-023417-by18aczt	219	21	the	the	DT
cord-023417-by18aczt	219	22	acceptor	acceptor	NN
cord-023417-by18aczt	219	23	substrates	substrate	NNS
cord-023417-by18aczt	219	24	are	be	VBP
cord-023417-by18aczt	219	25	oriented	orient	VBN
cord-023417-by18aczt	219	26	by	by	IN
cord-023417-by18aczt	219	27	nonconserved	nonconserved	JJ
cord-023417-by18aczt	219	28	regions	region	NNS
cord-023417-by18aczt	219	29	.	.	.
cord-023417-by18aczt	220	1	The	the	DT
cord-023417-by18aczt	220	2	2	2	CD
cord-023417-by18aczt	220	3	0	0	CD
cord-023417-by18aczt	220	4	-5	-5	NNP
cord-023417-by18aczt	220	5	0oligoadenylate	0oligoadenylate	CD
cord-023417-by18aczt	220	6	synthetases	synthetase	NNS
cord-023417-by18aczt	220	7	are	be	VBP
cord-023417-by18aczt	220	8	activated	activate	VBN
cord-023417-by18aczt	220	9	by	by	IN
cord-023417-by18aczt	220	10	viral	viral	JJ
cord-023417-by18aczt	220	11	doublestranded	doublestranded	NNP
cord-023417-by18aczt	220	12	RNA	RNA	NNP
cord-023417-by18aczt	220	13	in	in	IN
cord-023417-by18aczt	220	14	infected	infected	JJ
cord-023417-by18aczt	220	15	cells	cell	NNS
cord-023417-by18aczt	220	16	and	and	CC
cord-023417-by18aczt	220	17	initiate	initiate	VB
cord-023417-by18aczt	220	18	a	a	DT
cord-023417-by18aczt	220	19	cellular	cellular	JJ
cord-023417-by18aczt	220	20	response	response	NN
cord-023417-by18aczt	220	21	by	by	IN
cord-023417-by18aczt	220	22	synthesizing	synthesize	VBG
cord-023417-by18aczt	220	23	2	2	CD
cord-023417-by18aczt	220	24	0	0	CD
cord-023417-by18aczt	220	25	-5	-5	CD
cord-023417-by18aczt	220	26	0	0	CD
cord-023417-by18aczt	220	27	-oligoadenylates	-oligoadenylate	NNS
cord-023417-by18aczt	220	28	,	,	,
cord-023417-by18aczt	220	29	that	that	IN
cord-023417-by18aczt	220	30	in	in	IN
cord-023417-by18aczt	220	31	turn	turn	NN
cord-023417-by18aczt	220	32	activate	activate	VBP
cord-023417-by18aczt	220	33	RNase	RNase	NNP
cord-023417-by18aczt	220	34	L.	L.	NNP
cord-023417-by18aczt	221	1	This	this	DT
cord-023417-by18aczt	221	2	crystal	crystal	NN
cord-023417-by18aczt	221	3	structure	structure	NN
cord-023417-by18aczt	221	4	suggests	suggest	VBZ
cord-023417-by18aczt	221	5	that	that	IN
cord-023417-by18aczt	221	6	activation	activation	NN
cord-023417-by18aczt	221	7	involves	involve	VBZ
cord-023417-by18aczt	221	8	a	a	DT
cord-023417-by18aczt	221	9	domain	domain	NN
cord-023417-by18aczt	221	10	-	-	HYPH
cord-023417-by18aczt	221	11	domain	domain	NN
cord-023417-by18aczt	221	12	shift	shift	NN
cord-023417-by18aczt	221	13	and	and	CC
cord-023417-by18aczt	221	14	identifies	identify	VBZ
cord-023417-by18aczt	221	15	a	a	DT
cord-023417-by18aczt	221	16	putative	putative	JJ
cord-023417-by18aczt	221	17	dsRNA	dsrna	NN
cord-023417-by18aczt	221	18	activation	activation	NN
cord-023417-by18aczt	221	19	site	site	NN
cord-023417-by18aczt	221	20	that	that	WDT
cord-023417-by18aczt	221	21	is	be	VBZ
cord-023417-by18aczt	221	22	probed	probe	VBN
cord-023417-by18aczt	221	23	by	by	IN
cord-023417-by18aczt	221	24	mutagenesis	mutagenesis	NN
cord-023417-by18aczt	221	25	.	.	.
cord-023417-by18aczt	222	1	We	-PRON-	PRP
cord-023417-by18aczt	222	2	demonstrated	demonstrate	VBD
cord-023417-by18aczt	222	3	that	that	IN
cord-023417-by18aczt	222	4	this	this	DT
cord-023417-by18aczt	222	5	site	site	NN
cord-023417-by18aczt	222	6	is	be	VBZ
cord-023417-by18aczt	222	7	required	require	VBN
cord-023417-by18aczt	222	8	both	both	CC
cord-023417-by18aczt	222	9	for	for	IN
cord-023417-by18aczt	222	10	the	the	DT
cord-023417-by18aczt	222	11	binding	binding	NN
cord-023417-by18aczt	222	12	of	of	IN
cord-023417-by18aczt	222	13	dsRNA	dsrna	NN
cord-023417-by18aczt	222	14	and	and	CC
cord-023417-by18aczt	222	15	for	for	IN
cord-023417-by18aczt	222	16	the	the	DT
cord-023417-by18aczt	222	17	subsequent	subsequent	JJ
cord-023417-by18aczt	222	18	activation	activation	NN
cord-023417-by18aczt	222	19	of	of	IN
cord-023417-by18aczt	222	20	OAS	OAS	NNP
cord-023417-by18aczt	222	21	.	.	.
cord-023417-by18aczt	223	1	This	this	DT
cord-023417-by18aczt	223	2	RNA	rna	NN
cord-023417-by18aczt	223	3	-	-	HYPH
cord-023417-by18aczt	223	4	binding	bind	VBG
cord-023417-by18aczt	223	5	site	site	NN
cord-023417-by18aczt	223	6	is	be	VBZ
cord-023417-by18aczt	223	7	different	different	JJ
cord-023417-by18aczt	223	8	from	from	IN
cord-023417-by18aczt	223	9	known	know	VBN
cord-023417-by18aczt	223	10	RNA	rna	NN
cord-023417-by18aczt	223	11	-	-	HYPH
cord-023417-by18aczt	223	12	binding	bind	VBG
cord-023417-by18aczt	223	13	site	site	NN
cord-023417-by18aczt	223	14	;	;	:
cord-023417-by18aczt	223	15	rather	rather	RB
cord-023417-by18aczt	223	16	than	than	IN
cord-023417-by18aczt	223	17	forming	form	VBG
cord-023417-by18aczt	223	18	a	a	DT
cord-023417-by18aczt	223	19	defined	define	VBN
cord-023417-by18aczt	223	20	three	three	CD
cord-023417-by18aczt	223	21	-	-	HYPH
cord-023417-by18aczt	223	22	dimensional	dimensional	JJ
cord-023417-by18aczt	223	23	domain	domain	NN
cord-023417-by18aczt	223	24	,	,	,
cord-023417-by18aczt	223	25	it	-PRON-	PRP
cord-023417-by18aczt	223	26	is	be	VBZ
cord-023417-by18aczt	223	27	located	locate	VBN
cord-023417-by18aczt	223	28	at	at	IN
cord-023417-by18aczt	223	29	the	the	DT
cord-023417-by18aczt	223	30	interface	interface	NN
cord-023417-by18aczt	223	31	of	of	IN
cord-023417-by18aczt	223	32	the	the	DT
cord-023417-by18aczt	223	33	two	two	CD
cord-023417-by18aczt	223	34	major	major	JJ
cord-023417-by18aczt	223	35	domains	domain	NNS
cord-023417-by18aczt	223	36	in	in	IN
cord-023417-by18aczt	223	37	OAS	OAS	NNP
cord-023417-by18aczt	223	38	.	.	.
cord-023417-by18aczt	224	1	This	this	DT
cord-023417-by18aczt	224	2	novel	novel	NN
cord-023417-by18aczt	224	3	architecture	architecture	NN
cord-023417-by18aczt	224	4	ensures	ensure	VBZ
cord-023417-by18aczt	224	5	that	that	IN
cord-023417-by18aczt	224	6	the	the	DT
cord-023417-by18aczt	224	7	dsRNA	dsrna	NN
cord-023417-by18aczt	224	8	helix	helix	NN
cord-023417-by18aczt	224	9	can	can	MD
cord-023417-by18aczt	224	10	make	make	VB
cord-023417-by18aczt	224	11	simultaneously	simultaneously	RB
cord-023417-by18aczt	224	12	contact	contact	VB
cord-023417-by18aczt	224	13	with	with	IN
cord-023417-by18aczt	224	14	both	both	DT
cord-023417-by18aczt	224	15	domains	domain	NNS
cord-023417-by18aczt	224	16	of	of	IN
cord-023417-by18aczt	224	17	OAS	OAS	NNP
cord-023417-by18aczt	224	18	and	and	CC
cord-023417-by18aczt	224	19	ensure	ensure	VB
cord-023417-by18aczt	224	20	the	the	DT
cord-023417-by18aczt	224	21	subsequent	subsequent	JJ
cord-023417-by18aczt	224	22	structural	structural	JJ
cord-023417-by18aczt	224	23	rearrangement	rearrangement	NN
cord-023417-by18aczt	224	24	leading	lead	VBG
cord-023417-by18aczt	224	25	to	to	IN
cord-023417-by18aczt	224	26	the	the	DT
cord-023417-by18aczt	224	27	activation	activation	NN
cord-023417-by18aczt	224	28	of	of	IN
cord-023417-by18aczt	224	29	OAS	OAS	NNP
cord-023417-by18aczt	224	30	.	.	.
cord-023417-by18aczt	225	1	Our	-PRON-	PRP$
cord-023417-by18aczt	225	2	work	work	NN
cord-023417-by18aczt	225	3	provides	provide	VBZ
cord-023417-by18aczt	225	4	structural	structural	JJ
cord-023417-by18aczt	225	5	insight	insight	NN
cord-023417-by18aczt	225	6	into	into	IN
cord-023417-by18aczt	225	7	cellular	cellular	JJ
cord-023417-by18aczt	225	8	recognition	recognition	NN
cord-023417-by18aczt	225	9	of	of	IN
cord-023417-by18aczt	225	10	double	double	RB
cord-023417-by18aczt	225	11	-	-	HYPH
cord-023417-by18aczt	225	12	stranded	strand	VBN
cord-023417-by18aczt	225	13	RNA	RNA	NNP
cord-023417-by18aczt	225	14	of	of	IN
cord-023417-by18aczt	225	15	viral	viral	JJ
cord-023417-by18aczt	225	16	origin	origin	NN
cord-023417-by18aczt	225	17	and	and	CC
cord-023417-by18aczt	225	18	identifies	identify	VBZ
cord-023417-by18aczt	225	19	a	a	DT
cord-023417-by18aczt	225	20	novel	novel	JJ
cord-023417-by18aczt	225	21	RNA	rna	NN
cord-023417-by18aczt	225	22	-	-	HYPH
cord-023417-by18aczt	225	23	binding	bind	VBG
cord-023417-by18aczt	225	24	motif	motif	NN
cord-023417-by18aczt	225	25	.	.	.
cord-023417-by18aczt	226	1	Bacteria	Bacteria	NNS
cord-023417-by18aczt	226	2	-	-	HYPH
cord-023417-by18aczt	226	3	specific	specific	JJ
cord-023417-by18aczt	226	4	IgA	IgA	NNP
cord-023417-by18aczt	226	5	antibodies	antibody	NNS
cord-023417-by18aczt	226	6	are	be	VBP
cord-023417-by18aczt	226	7	efficient	efficient	JJ
cord-023417-by18aczt	226	8	opsonins	opsonin	NNS
cord-023417-by18aczt	226	9	for	for	IN
cord-023417-by18aczt	226	10	neutrophils	neutrophil	NNS
cord-023417-by18aczt	226	11	and	and	CC
cord-023417-by18aczt	226	12	mononuclear	mononuclear	JJ
cord-023417-by18aczt	226	13	phagocytes	phagocyte	NNS
cord-023417-by18aczt	226	14	,	,	,
cord-023417-by18aczt	226	15	provided	provide	VBD
cord-023417-by18aczt	226	16	that	that	IN
cord-023417-by18aczt	226	17	the	the	DT
cord-023417-by18aczt	226	18	phagocytes	phagocyte	NNS
cord-023417-by18aczt	226	19	express	express	VBP
cord-023417-by18aczt	226	20	the	the	DT
cord-023417-by18aczt	226	21	Fca	Fca	NNP
cord-023417-by18aczt	226	22	receptor	receptor	NN
cord-023417-by18aczt	226	23	(	(	-LRB-
cord-023417-by18aczt	226	24	CD89	CD89	NNP
cord-023417-by18aczt	226	25	)	)	-RRB-
cord-023417-by18aczt	226	26	.	.	.
cord-023417-by18aczt	227	1	Expression	expression	NN
cord-023417-by18aczt	227	2	of	of	IN
cord-023417-by18aczt	227	3	CD89	CD89	NNP
cord-023417-by18aczt	227	4	can	can	MD
cord-023417-by18aczt	227	5	be	be	VB
cord-023417-by18aczt	227	6	stimulated	stimulate	VBN
cord-023417-by18aczt	227	7	by	by	IN
cord-023417-by18aczt	227	8	inflammatory	inflammatory	JJ
cord-023417-by18aczt	227	9	cytokines	cytokine	NNS
cord-023417-by18aczt	227	10	,	,	,
cord-023417-by18aczt	227	11	activated	activate	VBN
cord-023417-by18aczt	227	12	complement	complement	NN
cord-023417-by18aczt	227	13	factors	factor	NNS
cord-023417-by18aczt	227	14	and	and	CC
cord-023417-by18aczt	227	15	certain	certain	JJ
cord-023417-by18aczt	227	16	microbial	microbial	JJ
cord-023417-by18aczt	227	17	components	component	NNS
cord-023417-by18aczt	227	18	.	.	.
cord-023417-by18aczt	228	1	In	in	IN
cord-023417-by18aczt	228	2	one	one	CD
cord-023417-by18aczt	228	3	study	study	NN
cord-023417-by18aczt	228	4	,	,	,
cord-023417-by18aczt	228	5	unstimulated	unstimulated	JJ
cord-023417-by18aczt	228	6	phagocytes	phagocyte	NNS
cord-023417-by18aczt	228	7	were	be	VBD
cord-023417-by18aczt	228	8	able	able	JJ
cord-023417-by18aczt	228	9	to	to	TO
cord-023417-by18aczt	228	10	ingest	ingest	VB
cord-023417-by18aczt	228	11	IgA	IgA	NNP
cord-023417-by18aczt	228	12	antibody	antibody	NN
cord-023417-by18aczt	228	13	-	-	HYPH
cord-023417-by18aczt	228	14	treated	treat	VBN
cord-023417-by18aczt	228	15	pneumococci	pneumococci	NN
cord-023417-by18aczt	228	16	,	,	,
cord-023417-by18aczt	228	17	but	but	CC
cord-023417-by18aczt	228	18	only	only	RB
cord-023417-by18aczt	228	19	in	in	IN
cord-023417-by18aczt	228	20	the	the	DT
cord-023417-by18aczt	228	21	presence	presence	NN
cord-023417-by18aczt	228	22	of	of	IN
cord-023417-by18aczt	228	23	complement	complement	NN
cord-023417-by18aczt	228	24	,	,	,
cord-023417-by18aczt	228	25	which	which	WDT
cord-023417-by18aczt	228	26	was	be	VBD
cord-023417-by18aczt	228	27	found	find	VBN
cord-023417-by18aczt	228	28	to	to	TO
cord-023417-by18aczt	228	29	be	be	VB
cord-023417-by18aczt	228	30	activated	activate	VBN
cord-023417-by18aczt	228	31	by	by	IN
cord-023417-by18aczt	228	32	the	the	DT
cord-023417-by18aczt	228	33	IgA	IgA	NNP
cord-023417-by18aczt	228	34	antibodies	antibody	NNS
cord-023417-by18aczt	228	35	along	along	IN
cord-023417-by18aczt	228	36	the	the	DT
cord-023417-by18aczt	228	37	alternative	alternative	JJ
cord-023417-by18aczt	228	38	pathway	pathway	NN
cord-023417-by18aczt	228	39	.	.	.
cord-023417-by18aczt	229	1	Pneumococci	pneumococcus	NNS
cord-023417-by18aczt	229	2	produce	produce	VBP
cord-023417-by18aczt	229	3	IgA1	iga1	PRP
cord-023417-by18aczt	229	4	protease	protease	NN
cord-023417-by18aczt	229	5	that	that	WDT
cord-023417-by18aczt	229	6	cleaves	cleave	VBZ
cord-023417-by18aczt	229	7	human	human	JJ
cord-023417-by18aczt	229	8	IgA1	IgA1	NNP
cord-023417-by18aczt	229	9	,	,	,
cord-023417-by18aczt	229	10	but	but	CC
cord-023417-by18aczt	229	11	not	not	RB
cord-023417-by18aczt	229	12	IgA2	IgA2	VBN
cord-023417-by18aczt	229	13	,	,	,
cord-023417-by18aczt	229	14	molecules	molecule	NNS
cord-023417-by18aczt	229	15	in	in	IN
cord-023417-by18aczt	229	16	the	the	DT
cord-023417-by18aczt	229	17	hinge	hinge	NN
cord-023417-by18aczt	229	18	region	region	NN
cord-023417-by18aczt	229	19	.	.	.
cord-023417-by18aczt	230	1	This	this	DT
cord-023417-by18aczt	230	2	leaves	leave	VBZ
cord-023417-by18aczt	230	3	IgA1	iga1	PRP
cord-023417-by18aczt	230	4	as	as	IN
cord-023417-by18aczt	230	5	Faba	Faba	NNP
cord-023417-by18aczt	230	6	(	(	-LRB-
cord-023417-by18aczt	230	7	monovalent	monovalent	NN
cord-023417-by18aczt	230	8	)	)	-RRB-
cord-023417-by18aczt	230	9	deprived	deprive	VBN
cord-023417-by18aczt	230	10	of	of	IN
cord-023417-by18aczt	230	11	Fca	Fca	NNP
cord-023417-by18aczt	230	12	which	which	WDT
cord-023417-by18aczt	230	13	contains	contain	VBZ
cord-023417-by18aczt	230	14	the	the	DT
cord-023417-by18aczt	230	15	docking	docking	NN
cord-023417-by18aczt	230	16	site	site	NN
cord-023417-by18aczt	230	17	for	for	IN
cord-023417-by18aczt	230	18	CD89	CD89	NNP
cord-023417-by18aczt	230	19	.	.	.
cord-023417-by18aczt	231	1	IgA1	iga1	UH
cord-023417-by18aczt	231	2	is	be	VBZ
cord-023417-by18aczt	231	3	the	the	DT
cord-023417-by18aczt	231	4	vastly	vastly	RB
cord-023417-by18aczt	231	5	predominant	predominant	JJ
cord-023417-by18aczt	231	6	subclass	subclass	NN
cord-023417-by18aczt	231	7	of	of	IN
cord-023417-by18aczt	231	8	IgA	IgA	NNP
cord-023417-by18aczt	231	9	in	in	IN
cord-023417-by18aczt	231	10	the	the	DT
cord-023417-by18aczt	231	11	upper	upper	NNP
cord-023417-by18aczt	231	12	airways	airway	NNS
cord-023417-by18aczt	231	13	and	and	CC
cord-023417-by18aczt	231	14	circulation	circulation	NN
cord-023417-by18aczt	231	15	of	of	IN
cord-023417-by18aczt	231	16	humans	human	NNS
cord-023417-by18aczt	231	17	.	.	.
cord-023417-by18aczt	232	1	Aims	aim	VBZ
cord-023417-by18aczt	232	2	:	:	:
cord-023417-by18aczt	233	1	To	to	TO
cord-023417-by18aczt	233	2	examine	examine	VB
cord-023417-by18aczt	233	3	the	the	DT
cord-023417-by18aczt	233	4	effects	effect	NNS
cord-023417-by18aczt	233	5	of	of	IN
cord-023417-by18aczt	233	6	IgA1	iga1	CD
cord-023417-by18aczt	233	7	protease	protease	NN
cord-023417-by18aczt	233	8	activity	activity	NN
cord-023417-by18aczt	233	9	and	and	CC
cord-023417-by18aczt	233	10	complement	complement	VB
cord-023417-by18aczt	233	11	on	on	IN
cord-023417-by18aczt	233	12	phagocytosis	phagocytosis	NN
cord-023417-by18aczt	233	13	of	of	IN
cord-023417-by18aczt	233	14	IgA	IgA	NNP
cord-023417-by18aczt	233	15	antibody	antibody	NN
cord-023417-by18aczt	233	16	-	-	HYPH
cord-023417-by18aczt	233	17	coated	coat	VBN
cord-023417-by18aczt	233	18	pneumococci	pneumococcus	NNS
cord-023417-by18aczt	233	19	by	by	IN
cord-023417-by18aczt	233	20	an	an	DT
cord-023417-by18aczt	233	21	unstimulated	unstimulated	JJ
cord-023417-by18aczt	233	22	human	human	JJ
cord-023417-by18aczt	233	23	phagocytic	phagocytic	JJ
cord-023417-by18aczt	233	24	cell	cell	NN
cord-023417-by18aczt	233	25	line	line	NN
cord-023417-by18aczt	233	26	(	(	-LRB-
cord-023417-by18aczt	233	27	hl60	hl60	NNP
cord-023417-by18aczt	233	28	)	)	-RRB-
cord-023417-by18aczt	233	29	.	.	.
cord-023417-by18aczt	234	1	Materials	material	NNS
cord-023417-by18aczt	234	2	and	and	CC
cord-023417-by18aczt	234	3	methods	method	NNS
cord-023417-by18aczt	234	4	:	:	:
cord-023417-by18aczt	234	5	IgA1	iga1	ADD
cord-023417-by18aczt	234	6	and	and	CC
cord-023417-by18aczt	234	7	IgA2	IgA2	VBD
cord-023417-by18aczt	234	8	monoclonal	monoclonal	JJ
cord-023417-by18aczt	234	9	antibodies	antibody	NNS
cord-023417-by18aczt	234	10	to	to	IN
cord-023417-by18aczt	234	11	serotype	serotype	NN
cord-023417-by18aczt	234	12	4	4	CD
cord-023417-by18aczt	234	13	pneumococcal	pneumococcal	JJ
cord-023417-by18aczt	234	14	capsular	capsular	NN
cord-023417-by18aczt	234	15	polysaccharide	polysaccharide	NN
cord-023417-by18aczt	234	16	(	(	-LRB-
cord-023417-by18aczt	234	17	ps	ps	UH
cord-023417-by18aczt	234	18	)	)	-RRB-
cord-023417-by18aczt	234	19	were	be	VBD
cord-023417-by18aczt	234	20	generated	generate	VBN
cord-023417-by18aczt	234	21	by	by	IN
cord-023417-by18aczt	234	22	heterohybridoma	heterohybridoma	NN
cord-023417-by18aczt	234	23	technique	technique	NN
cord-023417-by18aczt	234	24	involving	involve	VBG
cord-023417-by18aczt	234	25	B	b	NN
cord-023417-by18aczt	234	26	cells	cell	NNS
cord-023417-by18aczt	234	27	from	from	IN
cord-023417-by18aczt	234	28	human	human	JJ
cord-023417-by18aczt	234	29	vaccinees	vaccinee	NNS
cord-023417-by18aczt	234	30	.	.	.
cord-023417-by18aczt	235	1	Isogenic	Isogenic	NNP
cord-023417-by18aczt	235	2	serotype	serotype	NN
cord-023417-by18aczt	235	3	4	4	CD
cord-023417-by18aczt	235	4	pneumococci	pneumococcus	NNS
cord-023417-by18aczt	235	5	with	with	IN
cord-023417-by18aczt	235	6	and	and	CC
cord-023417-by18aczt	235	7	without	without	IN
cord-023417-by18aczt	235	8	IgA1	iga1	PRP$
cord-023417-by18aczt	235	9	protease	protease	NN
cord-023417-by18aczt	235	10	activity	activity	NN
cord-023417-by18aczt	235	11	,	,	,
cord-023417-by18aczt	235	12	respectively	respectively	RB
cord-023417-by18aczt	235	13	,	,	,
cord-023417-by18aczt	235	14	were	be	VBD
cord-023417-by18aczt	235	15	obtained	obtain	VBN
cord-023417-by18aczt	235	16	after	after	IN
cord-023417-by18aczt	235	17	inactivation	inactivation	NN
cord-023417-by18aczt	235	18	of	of	IN
cord-023417-by18aczt	235	19	the	the	DT
cord-023417-by18aczt	235	20	iga	iga	NNP
cord-023417-by18aczt	235	21	gene	gene	NN
cord-023417-by18aczt	235	22	of	of	IN
cord-023417-by18aczt	235	23	the	the	DT
cord-023417-by18aczt	235	24	TIGR4	TIGR4	NNP
cord-023417-by18aczt	235	25	strain	strain	NN
cord-023417-by18aczt	235	26	.	.	.
cord-023417-by18aczt	236	1	Opsonophagocytosis	Opsonophagocytosis	NNP
cord-023417-by18aczt	236	2	was	be	VBD
cord-023417-by18aczt	236	3	quantitated	quantitate	VBN
cord-023417-by18aczt	236	4	using	use	VBG
cord-023417-by18aczt	236	5	the	the	DT
cord-023417-by18aczt	236	6	assay	assay	NN
cord-023417-by18aczt	236	7	described	describe	VBN
cord-023417-by18aczt	236	8	by	by	IN
cord-023417-by18aczt	236	9	Romero	Romero	NNP
cord-023417-by18aczt	236	10	-	-	HYPH
cord-023417-by18aczt	236	11	Steiner	Steiner	NNP
cord-023417-by18aczt	236	12	et	et	NNP
cord-023417-by18aczt	236	13	al	al	NNP
cord-023417-by18aczt	236	14	.	.	.
cord-023417-by18aczt	237	1	Based	base	VBN
cord-023417-by18aczt	237	2	on	on	IN
cord-023417-by18aczt	237	3	enumeration	enumeration	NN
cord-023417-by18aczt	237	4	of	of	IN
cord-023417-by18aczt	237	5	surviving	survive	VBG
cord-023417-by18aczt	237	6	bacteria	bacteria	NNS
cord-023417-by18aczt	237	7	by	by	IN
cord-023417-by18aczt	237	8	culture	culture	NN
cord-023417-by18aczt	237	9	.	.	.
cord-023417-by18aczt	238	1	The	the	DT
cord-023417-by18aczt	238	2	integrity	integrity	NN
cord-023417-by18aczt	238	3	of	of	IN
cord-023417-by18aczt	238	4	IgA	IgA	NNP
cord-023417-by18aczt	238	5	molecules	molecule	NNS
cord-023417-by18aczt	238	6	was	be	VBD
cord-023417-by18aczt	238	7	examined	examine	VBN
cord-023417-by18aczt	238	8	by	by	IN
cord-023417-by18aczt	238	9	western	western	JJ
cord-023417-by18aczt	238	10	blotting	blotting	NN
cord-023417-by18aczt	238	11	.	.	.
cord-023417-by18aczt	239	1	Results	result	NNS
cord-023417-by18aczt	239	2	:	:	:
cord-023417-by18aczt	240	1	Both	both	CC
cord-023417-by18aczt	240	2	IgA1	iga1	PRP
cord-023417-by18aczt	240	3	and	and	CC
cord-023417-by18aczt	240	4	IgA2	IgA2	VBD
cord-023417-by18aczt	240	5	antibody	antibody	NN
cord-023417-by18aczt	240	6	to	to	IN
cord-023417-by18aczt	240	7	type-4	type-4	NNP
cord-023417-by18aczt	240	8	polysaccharide	polysaccharide	NN
cord-023417-by18aczt	240	9	-	-	HYPH
cord-023417-by18aczt	240	10	induced	induce	VBN
cord-023417-by18aczt	240	11	phagocytosis	phagocytosis	NN
cord-023417-by18aczt	240	12	of	of	IN
cord-023417-by18aczt	240	13	IgA1	iga1	DT
cord-023417-by18aczt	240	14	protease	protease	NN
cord-023417-by18aczt	240	15	-	-	HYPH
cord-023417-by18aczt	240	16	deficient	deficient	JJ
cord-023417-by18aczt	241	1	type-4	type-4	NNP
cord-023417-by18aczt	241	2	pneumococci	pneumococcus	NNS
cord-023417-by18aczt	241	3	equally	equally	RB
cord-023417-by18aczt	241	4	well	well	RB
cord-023417-by18aczt	241	5	in	in	IN
cord-023417-by18aczt	241	6	the	the	DT
cord-023417-by18aczt	241	7	absence	absence	NN
cord-023417-by18aczt	241	8	as	as	IN
cord-023417-by18aczt	241	9	in	in	IN
cord-023417-by18aczt	241	10	the	the	DT
cord-023417-by18aczt	241	11	presence	presence	NN
cord-023417-by18aczt	241	12	of	of	IN
cord-023417-by18aczt	241	13	complement	complement	NN
cord-023417-by18aczt	241	14	.	.	.
cord-023417-by18aczt	242	1	Iga1	iga1	JJ
cord-023417-by18aczt	242	2	antibody	antibody	NN
cord-023417-by18aczt	242	3	to	to	IN
cord-023417-by18aczt	242	4	type-4	type-4	NNP
cord-023417-by18aczt	242	5	polysaccharide	polysaccharide	NN
cord-023417-by18aczt	242	6	displayed	display	VBD
cord-023417-by18aczt	242	7	a	a	DT
cord-023417-by18aczt	242	8	fourfold	fourfold	JJ
cord-023417-by18aczt	242	9	higher	high	JJR
cord-023417-by18aczt	242	10	opsonophagocytosis	opsonophagocytosis	NN
cord-023417-by18aczt	242	11	titer	titer	NN
cord-023417-by18aczt	242	12	against	against	IN
cord-023417-by18aczt	242	13	IgA1	iga1	XX
cord-023417-by18aczt	242	14	protease	protease	NN
cord-023417-by18aczt	242	15	deficient	deficient	JJ
cord-023417-by18aczt	242	16	compared	compare	VBN
cord-023417-by18aczt	242	17	to	to	IN
cord-023417-by18aczt	242	18	homologous	homologous	JJ
cord-023417-by18aczt	242	19	wildtype	wildtype	NN
cord-023417-by18aczt	242	20	target	target	NN
cord-023417-by18aczt	242	21	bacteria	bacteria	NNS
cord-023417-by18aczt	242	22	.	.	.
cord-023417-by18aczt	243	1	A	a	DT
cord-023417-by18aczt	243	2	similar	similar	JJ
cord-023417-by18aczt	243	3	effect	effect	NN
cord-023417-by18aczt	243	4	of	of	IN
cord-023417-by18aczt	243	5	IgA1	iga1	CD
cord-023417-by18aczt	243	6	protease	protease	NN
cord-023417-by18aczt	243	7	activity	activity	NN
cord-023417-by18aczt	243	8	of	of	IN
cord-023417-by18aczt	243	9	the	the	DT
cord-023417-by18aczt	243	10	target	target	NN
cord-023417-by18aczt	243	11	bacteria	bacteria	NNS
cord-023417-by18aczt	243	12	was	be	VBD
cord-023417-by18aczt	243	13	not	not	RB
cord-023417-by18aczt	243	14	observed	observe	VBN
cord-023417-by18aczt	243	15	in	in	IN
cord-023417-by18aczt	243	16	a	a	DT
cord-023417-by18aczt	243	17	parallel	parallel	JJ
cord-023417-by18aczt	243	18	experiment	experiment	NN
cord-023417-by18aczt	243	19	where	where	WRB
cord-023417-by18aczt	243	20	IgA2	iga2	JJ
cord-023417-by18aczt	243	21	antibody	antibody	NN
cord-023417-by18aczt	243	22	to	to	IN
cord-023417-by18aczt	243	23	type-4	type-4	NNP
cord-023417-by18aczt	243	24	polysaccharide	polysaccharide	NN
cord-023417-by18aczt	243	25	served	serve	VBD
cord-023417-by18aczt	243	26	as	as	IN
cord-023417-by18aczt	243	27	opsonin	opsonin	NNP
cord-023417-by18aczt	243	28	.	.	.
cord-023417-by18aczt	244	1	IgA1	iga1	DT
cord-023417-by18aczt	244	2	antibody	antibody	NN
cord-023417-by18aczt	244	3	extracted	extract	VBD
cord-023417-by18aczt	244	4	from	from	IN
cord-023417-by18aczt	244	5	IgA1	iga1	DT
cord-023417-by18aczt	244	6	protease	protease	NN
cord-023417-by18aczt	244	7	-	-	HYPH
cord-023417-by18aczt	244	8	producing	produce	VBG
cord-023417-by18aczt	244	9	target	target	NN
cord-023417-by18aczt	244	10	bacteria	bacteria	NNS
cord-023417-by18aczt	244	11	was	be	VBD
cord-023417-by18aczt	244	12	almost	almost	RB
cord-023417-by18aczt	244	13	exclusively	exclusively	RB
cord-023417-by18aczt	244	14	in	in	IN
cord-023417-by18aczt	244	15	the	the	DT
cord-023417-by18aczt	244	16	form	form	NN
cord-023417-by18aczt	244	17	of	of	IN
cord-023417-by18aczt	244	18	Faba	Faba	NNP
cord-023417-by18aczt	244	19	.	.	.
cord-023417-by18aczt	245	1	Conversely	conversely	RB
cord-023417-by18aczt	245	2	,	,	,
cord-023417-by18aczt	245	3	IgA1	iga1	RB
cord-023417-by18aczt	245	4	from	from	IN
cord-023417-by18aczt	245	5	protease	protease	NN
cord-023417-by18aczt	245	6	-	-	HYPH
cord-023417-by18aczt	245	7	deficient	deficient	JJ
cord-023417-by18aczt	245	8	bacteria	bacteria	NNS
cord-023417-by18aczt	245	9	and	and	CC
cord-023417-by18aczt	245	10	IgA2	iga2	NN
cord-023417-by18aczt	245	11	from	from	IN
cord-023417-by18aczt	245	12	both	both	DT
cord-023417-by18aczt	245	13	types	type	NNS
cord-023417-by18aczt	245	14	of	of	IN
cord-023417-by18aczt	245	15	bacteria	bacteria	NNS
cord-023417-by18aczt	245	16	were	be	VBD
cord-023417-by18aczt	245	17	intact	intact	JJ
cord-023417-by18aczt	245	18	.	.	.
cord-023417-by18aczt	246	1	Conclusions	conclusion	NNS
cord-023417-by18aczt	246	2	:	:	:
cord-023417-by18aczt	247	1	These	these	DT
cord-023417-by18aczt	247	2	results	result	NNS
cord-023417-by18aczt	247	3	indicate	indicate	VBP
cord-023417-by18aczt	247	4	that	that	IN
cord-023417-by18aczt	247	5	the	the	DT
cord-023417-by18aczt	247	6	IgA1	iga1	CD
cord-023417-by18aczt	247	7	protease	protease	NN
cord-023417-by18aczt	247	8	activity	activity	NN
cord-023417-by18aczt	247	9	of	of	IN
cord-023417-by18aczt	247	10	S.	S.	NNP
cord-023417-by18aczt	247	11	neumoniae	neumoniae	NNS
cord-023417-by18aczt	247	12	may	may	MD
cord-023417-by18aczt	247	13	help	help	VB
cord-023417-by18aczt	247	14	the	the	DT
cord-023417-by18aczt	247	15	bacteria	bacteria	NNS
cord-023417-by18aczt	247	16	escape	escape	VB
cord-023417-by18aczt	247	17	IgA1	iga1	ADD
cord-023417-by18aczt	247	18	antibody	antibody	NN
cord-023417-by18aczt	247	19	-	-	HYPH
cord-023417-by18aczt	247	20	mediated	mediate	VBN
cord-023417-by18aczt	247	21	opsonophagocytosis	opsonophagocytosis	NN
cord-023417-by18aczt	247	22	.	.	.
cord-023417-by18aczt	248	1	Besides	besides	RB
cord-023417-by18aczt	248	2	,	,	,
cord-023417-by18aczt	248	3	in	in	IN
cord-023417-by18aczt	248	4	these	these	DT
cord-023417-by18aczt	248	5	experiments	experiment	NNS
cord-023417-by18aczt	248	6	,	,	,
cord-023417-by18aczt	248	7	IgA	IgA	NNP
cord-023417-by18aczt	248	8	-	-	HYPH
cord-023417-by18aczt	248	9	mediated	mediate	VBN
cord-023417-by18aczt	248	10	opsonophagocytosis	opsonophagocytosis	NN
cord-023417-by18aczt	248	11	was	be	VBD
cord-023417-by18aczt	248	12	independent	independent	JJ
cord-023417-by18aczt	248	13	of	of	IN
cord-023417-by18aczt	248	14	complement	complement	NN
cord-023417-by18aczt	248	15	.	.	.
cord-023417-by18aczt	249	1	Vitamins	vitamin	NNS
cord-023417-by18aczt	249	2	E	e	NN
cord-023417-by18aczt	249	3	and	and	CC
cord-023417-by18aczt	249	4	C	C	NNP
cord-023417-by18aczt	249	5	have	have	VBP
cord-023417-by18aczt	249	6	been	be	VBN
cord-023417-by18aczt	249	7	found	find	VBN
cord-023417-by18aczt	249	8	to	to	TO
cord-023417-by18aczt	249	9	increase	increase	VB
cord-023417-by18aczt	249	10	the	the	DT
cord-023417-by18aczt	249	11	cellular	cellular	JJ
cord-023417-by18aczt	249	12	and	and	CC
cord-023417-by18aczt	249	13	humeral	humeral	JJ
cord-023417-by18aczt	249	14	immunity	immunity	NN
cord-023417-by18aczt	249	15	of	of	IN
cord-023417-by18aczt	249	16	pigs	pig	NNS
cord-023417-by18aczt	249	17	.	.	.
cord-023417-by18aczt	250	1	Vitamin	vitamin	NN
cord-023417-by18aczt	250	2	E	e	NN
cord-023417-by18aczt	250	3	deficiency	deficiency	NN
cord-023417-by18aczt	250	4	has	have	VBZ
cord-023417-by18aczt	250	5	also	also	RB
cord-023417-by18aczt	250	6	been	be	VBN
cord-023417-by18aczt	250	7	found	find	VBN
cord-023417-by18aczt	250	8	to	to	TO
cord-023417-by18aczt	250	9	predispose	predispose	VB
cord-023417-by18aczt	250	10	pigs	pig	NNS
cord-023417-by18aczt	250	11	to	to	IN
cord-023417-by18aczt	250	12	different	different	JJ
cord-023417-by18aczt	250	13	diseases	disease	NNS
cord-023417-by18aczt	250	14	,	,	,
cord-023417-by18aczt	250	15	E.	E.	NNP
cord-023417-by18aczt	250	16	coli	coli	VBZ
cord-023417-by18aczt	250	17	infection	infection	NN
cord-023417-by18aczt	250	18	is	be	VBZ
cord-023417-by18aczt	250	19	one	one	CD
cord-023417-by18aczt	250	20	among	among	IN
cord-023417-by18aczt	250	21	them	-PRON-	PRP
cord-023417-by18aczt	250	22	.	.	.
cord-023417-by18aczt	251	1	After	after	IN
cord-023417-by18aczt	251	2	weaning	wean	VBG
cord-023417-by18aczt	251	3	,	,	,
cord-023417-by18aczt	251	4	the	the	DT
cord-023417-by18aczt	251	5	vitamin	vitamin	NN
cord-023417-by18aczt	251	6	E	e	NN
cord-023417-by18aczt	251	7	status	status	NN
cord-023417-by18aczt	251	8	of	of	IN
cord-023417-by18aczt	251	9	pigs	pig	NNS
cord-023417-by18aczt	251	10	often	often	RB
cord-023417-by18aczt	251	11	decreases	decrease	VBZ
cord-023417-by18aczt	251	12	to	to	IN
cord-023417-by18aczt	251	13	a	a	DT
cord-023417-by18aczt	251	14	critical	critical	JJ
cord-023417-by18aczt	251	15	low	low	JJ
cord-023417-by18aczt	251	16	level	level	NN
cord-023417-by18aczt	251	17	.	.	.
cord-023417-by18aczt	252	1	In	in	IN
cord-023417-by18aczt	252	2	this	this	DT
cord-023417-by18aczt	252	3	experiment	experiment	NN
cord-023417-by18aczt	252	4	,	,	,
cord-023417-by18aczt	252	5	we	-PRON-	PRP
cord-023417-by18aczt	252	6	studied	study	VBD
cord-023417-by18aczt	252	7	whether	whether	IN
cord-023417-by18aczt	252	8	vitamin	vitamin	NN
cord-023417-by18aczt	252	9	C	c	NN
cord-023417-by18aczt	252	10	supplementation	supplementation	NN
cord-023417-by18aczt	252	11	would	would	MD
cord-023417-by18aczt	252	12	be	be	VB
cord-023417-by18aczt	252	13	a	a	DT
cord-023417-by18aczt	252	14	possible	possible	JJ
cord-023417-by18aczt	252	15	feeding	feeding	NN
cord-023417-by18aczt	252	16	strategy	strategy	NN
cord-023417-by18aczt	252	17	to	to	TO
cord-023417-by18aczt	252	18	optimize	optimize	VB
cord-023417-by18aczt	252	19	the	the	DT
cord-023417-by18aczt	252	20	immune	immune	JJ
cord-023417-by18aczt	252	21	status	status	NN
cord-023417-by18aczt	252	22	of	of	IN
cord-023417-by18aczt	252	23	weaners	weaner	NNS
cord-023417-by18aczt	252	24	.	.	.
cord-023417-by18aczt	253	1	The	the	DT
cord-023417-by18aczt	253	2	interaction	interaction	NN
cord-023417-by18aczt	253	3	between	between	IN
cord-023417-by18aczt	253	4	vitamin	vitamin	NN
cord-023417-by18aczt	253	5	E	e	NN
cord-023417-by18aczt	253	6	and	and	CC
cord-023417-by18aczt	253	7	C	C	NNP
cord-023417-by18aczt	253	8	is	be	VBZ
cord-023417-by18aczt	253	9	interesting	interesting	JJ
cord-023417-by18aczt	253	10	due	due	IN
cord-023417-by18aczt	253	11	to	to	IN
cord-023417-by18aczt	253	12	the	the	DT
cord-023417-by18aczt	253	13	reported	report	VBN
cord-023417-by18aczt	253	14	sparing	spare	VBG
cord-023417-by18aczt	253	15	action	action	NN
cord-023417-by18aczt	253	16	on	on	IN
cord-023417-by18aczt	253	17	vitamin	vitamin	NN
cord-023417-by18aczt	253	18	E	e	NN
cord-023417-by18aczt	253	19	or	or	CC
cord-023417-by18aczt	253	20	synergism	synergism	NN
cord-023417-by18aczt	253	21	between	between	IN
cord-023417-by18aczt	253	22	these	these	DT
cord-023417-by18aczt	253	23	to	to	IN
cord-023417-by18aczt	253	24	vitamins	vitamin	NNS
cord-023417-by18aczt	253	25	.	.	.
cord-023417-by18aczt	254	1	Piglets	piglet	NNS
cord-023417-by18aczt	254	2	were	be	VBD
cord-023417-by18aczt	254	3	weaned	wean	VBN
cord-023417-by18aczt	254	4	at	at	IN
cord-023417-by18aczt	254	5	day	day	NN
cord-023417-by18aczt	254	6	28	28	CD
cord-023417-by18aczt	254	7	of	of	IN
cord-023417-by18aczt	254	8	age	age	NN
cord-023417-by18aczt	254	9	from	from	IN
cord-023417-by18aczt	254	10	sows	sow	NNS
cord-023417-by18aczt	254	11	fed	feed	VBD
cord-023417-by18aczt	254	12	increasing	increase	VBG
cord-023417-by18aczt	254	13	dietary	dietary	JJ
cord-023417-by18aczt	254	14	vitamin	vitamin	NN
cord-023417-by18aczt	254	15	E	e	NN
cord-023417-by18aczt	254	16	during	during	IN
cord-023417-by18aczt	254	17	lactation	lactation	NN
cord-023417-by18aczt	254	18	,	,	,
cord-023417-by18aczt	254	19	and	and	CC
cord-023417-by18aczt	254	20	piglets	piglet	NNS
cord-023417-by18aczt	254	21	were	be	VBD
cord-023417-by18aczt	254	22	during	during	IN
cord-023417-by18aczt	254	23	the	the	DT
cord-023417-by18aczt	254	24	following	following	JJ
cord-023417-by18aczt	254	25	3	3	CD
cord-023417-by18aczt	254	26	weeks	week	NNS
cord-023417-by18aczt	254	27	fed	feed	VBN
cord-023417-by18aczt	254	28	either	either	CC
cord-023417-by18aczt	254	29	a	a	DT
cord-023417-by18aczt	254	30	control	control	NN
cord-023417-by18aczt	254	31	diet	diet	NN
cord-023417-by18aczt	254	32	or	or	CC
cord-023417-by18aczt	254	33	this	this	DT
cord-023417-by18aczt	254	34	diet	diet	NN
cord-023417-by18aczt	254	35	supplemented	supplement	VBD
cord-023417-by18aczt	254	36	with	with	IN
cord-023417-by18aczt	254	37	500	500	CD
cord-023417-by18aczt	254	38	mg	mg	NNP
cord-023417-by18aczt	254	39	STAY	stay	NN
cord-023417-by18aczt	254	40	-	-	HYPH
cord-023417-by18aczt	254	41	C	C	NNP
cord-023417-by18aczt	254	42	per	per	IN
cord-023417-by18aczt	254	43	kg	kg	NN
cord-023417-by18aczt	254	44	.	.	.
cord-023417-by18aczt	255	1	Blood	blood	NN
cord-023417-by18aczt	255	2	sampling	sampling	NN
cord-023417-by18aczt	255	3	was	be	VBD
cord-023417-by18aczt	255	4	obtained	obtain	VBN
cord-023417-by18aczt	255	5	weekly	weekly	RB
cord-023417-by18aczt	255	6	from	from	IN
cord-023417-by18aczt	255	7	day	day	NN
cord-023417-by18aczt	255	8	28	28	CD
cord-023417-by18aczt	255	9	and	and	CC
cord-023417-by18aczt	255	10	until	until	IN
cord-023417-by18aczt	255	11	day	day	NN
cord-023417-by18aczt	255	12	49	49	CD
cord-023417-by18aczt	255	13	of	of	IN
cord-023417-by18aczt	255	14	age	age	NN
cord-023417-by18aczt	255	15	.	.	.
cord-023417-by18aczt	256	1	On	on	IN
cord-023417-by18aczt	256	2	the	the	DT
cord-023417-by18aczt	256	3	same	same	JJ
cord-023417-by18aczt	256	4	days	day	NNS
cord-023417-by18aczt	256	5	,	,	,
cord-023417-by18aczt	256	6	one	one	CD
cord-023417-by18aczt	256	7	piglet	piglet	NN
cord-023417-by18aczt	256	8	per	per	IN
cord-023417-by18aczt	256	9	dietary	dietary	JJ
cord-023417-by18aczt	256	10	treatment	treatment	NN
cord-023417-by18aczt	256	11	was	be	VBD
cord-023417-by18aczt	256	12	killed	kill	VBN
cord-023417-by18aczt	256	13	and	and	CC
cord-023417-by18aczt	256	14	alveolar	alveolar	NN
cord-023417-by18aczt	256	15	macrophages	macrophage	NNS
cord-023417-by18aczt	256	16	(	(	-LRB-
cord-023417-by18aczt	256	17	AM	am	NN
cord-023417-by18aczt	256	18	)	)	-RRB-
cord-023417-by18aczt	256	19	were	be	VBD
cord-023417-by18aczt	256	20	harvested	harvest	VBN
cord-023417-by18aczt	256	21	.	.	.
cord-023417-by18aczt	257	1	Vitamin	vitamin	NN
cord-023417-by18aczt	257	2	C	c	NN
cord-023417-by18aczt	257	3	supplementation	supplementation	NN
cord-023417-by18aczt	257	4	increased	increase	VBD
cord-023417-by18aczt	257	5	the	the	DT
cord-023417-by18aczt	257	6	concentration	concentration	NN
cord-023417-by18aczt	257	7	of	of	IN
cord-023417-by18aczt	257	8	IgM	IgM	NNP
cord-023417-by18aczt	257	9	in	in	IN
cord-023417-by18aczt	257	10	serum	serum	NN
cord-023417-by18aczt	257	11	of	of	IN
cord-023417-by18aczt	257	12	piglets	piglet	NNS
cord-023417-by18aczt	257	13	throughout	throughout	IN
cord-023417-by18aczt	257	14	the	the	DT
cord-023417-by18aczt	257	15	weaning	weaning	NN
cord-023417-by18aczt	257	16	period	period	NN
cord-023417-by18aczt	257	17	.	.	.
cord-023417-by18aczt	258	1	Although	although	IN
cord-023417-by18aczt	258	2	the	the	DT
cord-023417-by18aczt	258	3	vitamin	vitamin	NN
cord-023417-by18aczt	258	4	E	e	NN
cord-023417-by18aczt	258	5	concentration	concentration	NN
cord-023417-by18aczt	258	6	in	in	IN
cord-023417-by18aczt	258	7	AM	AM	NNP
cord-023417-by18aczt	258	8	decreased	decrease	VBD
cord-023417-by18aczt	258	9	with	with	IN
cord-023417-by18aczt	258	10	increasing	increase	VBG
cord-023417-by18aczt	258	11	age	age	NN
cord-023417-by18aczt	258	12	of	of	IN
cord-023417-by18aczt	258	13	the	the	DT
cord-023417-by18aczt	258	14	piglets	piglet	NNS
cord-023417-by18aczt	258	15	,	,	,
cord-023417-by18aczt	258	16	the	the	DT
cord-023417-by18aczt	258	17	concentration	concentration	NN
cord-023417-by18aczt	258	18	was	be	VBD
cord-023417-by18aczt	258	19	numerically	numerically	RB
cord-023417-by18aczt	258	20	higher	high	JJR
cord-023417-by18aczt	258	21	in	in	IN
cord-023417-by18aczt	258	22	piglets	piglet	NNS
cord-023417-by18aczt	258	23	of	of	IN
cord-023417-by18aczt	258	24	sows	sow	NNS
cord-023417-by18aczt	258	25	fed	feed	VBD
cord-023417-by18aczt	258	26	the	the	DT
cord-023417-by18aczt	258	27	high	high	JJ
cord-023417-by18aczt	258	28	dietary	dietary	JJ
cord-023417-by18aczt	258	29	level	level	NN
cord-023417-by18aczt	258	30	of	of	IN
cord-023417-by18aczt	258	31	vitamin	vitamin	NN
cord-023417-by18aczt	258	32	E.	E.	NNP
cord-023417-by18aczt	259	1	However	however	RB
cord-023417-by18aczt	259	2	,	,	,
cord-023417-by18aczt	259	3	vitamin	vitamin	NN
cord-023417-by18aczt	259	4	C	c	NN
cord-023417-by18aczt	259	5	supplementation	supplementation	NN
cord-023417-by18aczt	259	6	tended	tend	VBD
cord-023417-by18aczt	259	7	to	to	TO
cord-023417-by18aczt	259	8	increase	increase	VB
cord-023417-by18aczt	259	9	the	the	DT
cord-023417-by18aczt	259	10	total	total	JJ
cord-023417-by18aczt	259	11	AM	AM	NNP
cord-023417-by18aczt	259	12	concentration	concentration	NN
cord-023417-by18aczt	259	13	of	of	IN
cord-023417-by18aczt	259	14	vitamin	vitamin	NN
cord-023417-by18aczt	259	15	E	e	NN
cord-023417-by18aczt	259	16	after	after	IN
cord-023417-by18aczt	259	17	weaning	weaning	NN
cord-023417-by18aczt	259	18	and	and	CC
cord-023417-by18aczt	259	19	increased	increase	VBD
cord-023417-by18aczt	259	20	the	the	DT
cord-023417-by18aczt	259	21	proportion	proportion	NN
cord-023417-by18aczt	259	22	of	of	IN
cord-023417-by18aczt	259	23	the	the	DT
cord-023417-by18aczt	259	24	biologically	biologically	RB
cord-023417-by18aczt	259	25	most	most	RBS
cord-023417-by18aczt	259	26	active	active	JJ
cord-023417-by18aczt	259	27	isomer	isomer	NN
cord-023417-by18aczt	259	28	of	of	IN
cord-023417-by18aczt	259	29	vitamin	vitamin	NN
cord-023417-by18aczt	259	30	E	e	NN
cord-023417-by18aczt	259	31	[	[	-LRB-
cord-023417-by18aczt	259	32	RRR-(a	rrr-(a	NN
cord-023417-by18aczt	259	33	-	-	HYPH
cord-023417-by18aczt	259	34	tocopherol	tocopherol	NN
cord-023417-by18aczt	259	35	)	)	-RRB-
cord-023417-by18aczt	259	36	]	]	-RRB-
cord-023417-by18aczt	259	37	in	in	IN
cord-023417-by18aczt	259	38	the	the	DT
cord-023417-by18aczt	259	39	AM	am	NN
cord-023417-by18aczt	259	40	.	.	.
cord-023417-by18aczt	260	1	The	the	DT
cord-023417-by18aczt	260	2	eicosanoid	eicosanoid	JJ
cord-023417-by18aczt	260	3	synthesis	synthesis	NN
cord-023417-by18aczt	260	4	by	by	IN
cord-023417-by18aczt	260	5	AM	AM	NNP
cord-023417-by18aczt	260	6	was	be	VBD
cord-023417-by18aczt	260	7	not	not	RB
cord-023417-by18aczt	260	8	influenced	influence	VBN
cord-023417-by18aczt	260	9	by	by	IN
cord-023417-by18aczt	260	10	the	the	DT
cord-023417-by18aczt	260	11	vitamin	vitamin	NN
cord-023417-by18aczt	260	12	C	C	NNP
cord-023417-by18aczt	260	13	supplementation	supplementation	NN
cord-023417-by18aczt	260	14	,	,	,
cord-023417-by18aczt	260	15	but	but	CC
cord-023417-by18aczt	260	16	the	the	DT
cord-023417-by18aczt	260	17	synthesis	synthesis	NN
cord-023417-by18aczt	260	18	of	of	IN
cord-023417-by18aczt	260	19	leukotriene	leukotriene	NN
cord-023417-by18aczt	260	20	B4	B4	NNP
cord-023417-by18aczt	260	21	was	be	VBD
cord-023417-by18aczt	260	22	decreased	decrease	VBN
cord-023417-by18aczt	260	23	2	2	CD
cord-023417-by18aczt	260	24	weeks	week	NNS
cord-023417-by18aczt	260	25	after	after	IN
cord-023417-by18aczt	260	26	weaning	wean	VBG
cord-023417-by18aczt	260	27	compared	compare	VBN
cord-023417-by18aczt	260	28	to	to	IN
cord-023417-by18aczt	260	29	other	other	JJ
cord-023417-by18aczt	260	30	days	day	NNS
cord-023417-by18aczt	260	31	of	of	IN
cord-023417-by18aczt	260	32	AM	AM	NNP
cord-023417-by18aczt	260	33	harvesting	harvest	VBG
cord-023417-by18aczt	260	34	.	.	.
cord-023417-by18aczt	261	1	In	in	IN
cord-023417-by18aczt	261	2	conclusion	conclusion	NN
cord-023417-by18aczt	261	3	,	,	,
cord-023417-by18aczt	261	4	dietary	dietary	JJ
cord-023417-by18aczt	261	5	vitamin	vitamin	NN
cord-023417-by18aczt	261	6	C	C	NNP
cord-023417-by18aczt	261	7	supplementation	supplementation	NN
cord-023417-by18aczt	261	8	improved	improve	VBD
cord-023417-by18aczt	261	9	the	the	DT
cord-023417-by18aczt	261	10	immune	immune	JJ
cord-023417-by18aczt	261	11	responses	response	NNS
cord-023417-by18aczt	261	12	of	of	IN
cord-023417-by18aczt	261	13	piglets	piglet	NNS
cord-023417-by18aczt	261	14	after	after	IN
cord-023417-by18aczt	261	15	weaning	wean	VBG
cord-023417-by18aczt	261	16	.	.	.
cord-023417-by18aczt	262	1	A	a	DT
cord-023417-by18aczt	262	2	whole	whole	JJ
cord-023417-by18aczt	262	3	blood	blood	NN
cord-023417-by18aczt	262	4	stimulation	stimulation	NN
cord-023417-by18aczt	262	5	assay	assay	NN
cord-023417-by18aczt	262	6	with	with	IN
cord-023417-by18aczt	262	7	Escherichia	Escherichia	NNP
cord-023417-by18aczt	262	8	coli	coli	NNS
cord-023417-by18aczt	262	9	(	(	-LRB-
cord-023417-by18aczt	262	10	O111	O111	NNS
cord-023417-by18aczt	262	11	:	:	:
cord-023417-by18aczt	262	12	B4	B4	NNP
cord-023417-by18aczt	262	13	)	)	-RRB-
cord-023417-by18aczt	262	14	endotoxin	endotoxin	NN
cord-023417-by18aczt	262	15	was	be	VBD
cord-023417-by18aczt	262	16	established	establish	VBN
cord-023417-by18aczt	262	17	to	to	TO
cord-023417-by18aczt	262	18	measure	measure	VB
cord-023417-by18aczt	262	19	the	the	DT
cord-023417-by18aczt	262	20	capacity	capacity	NN
cord-023417-by18aczt	262	21	of	of	IN
cord-023417-by18aczt	262	22	dairy	dairy	NN
cord-023417-by18aczt	262	23	cows	cow	NNS
cord-023417-by18aczt	262	24	to	to	TO
cord-023417-by18aczt	262	25	produce	produce	VB
cord-023417-by18aczt	262	26	the	the	DT
cord-023417-by18aczt	262	27	proinflammatory	proinflammatory	JJ
cord-023417-by18aczt	262	28	cytokine	cytokine	NN
cord-023417-by18aczt	262	29	tumour	tumour	NN
cord-023417-by18aczt	262	30	necrosis	necrosis	NN
cord-023417-by18aczt	262	31	factor	factor	NN
cord-023417-by18aczt	262	32	-	-	:
cord-023417-by18aczt	262	33	a	a	DT
cord-023417-by18aczt	262	34	(	(	-LRB-
cord-023417-by18aczt	262	35	TNF	TNF	NNP
cord-023417-by18aczt	262	36	-	-	HYPH
cord-023417-by18aczt	262	37	a	a	LS
cord-023417-by18aczt	262	38	)	)	-RRB-
cord-023417-by18aczt	262	39	ex	ex	FW
cord-023417-by18aczt	262	40	vivo	vivo	NN
cord-023417-by18aczt	262	41	.	.	.
cord-023417-by18aczt	263	1	Initially	initially	RB
cord-023417-by18aczt	263	2	,	,	,
cord-023417-by18aczt	263	3	a	a	DT
cord-023417-by18aczt	263	4	time	time	NN
cord-023417-by18aczt	263	5	-	-	HYPH
cord-023417-by18aczt	263	6	and	and	CC
cord-023417-by18aczt	263	7	dose	dose	NN
cord-023417-by18aczt	263	8	-	-	HYPH
cord-023417-by18aczt	263	9	dependent	dependent	JJ
cord-023417-by18aczt	263	10	study	study	NN
cord-023417-by18aczt	263	11	was	be	VBD
cord-023417-by18aczt	263	12	carried	carry	VBN
cord-023417-by18aczt	263	13	out	out	RP
cord-023417-by18aczt	263	14	to	to	TO
cord-023417-by18aczt	263	15	find	find	VB
cord-023417-by18aczt	263	16	the	the	DT
cord-023417-by18aczt	263	17	optimal	optimal	JJ
cord-023417-by18aczt	263	18	stimulation	stimulation	NN
cord-023417-by18aczt	263	19	conditions	condition	NNS
cord-023417-by18aczt	263	20	for	for	IN
cord-023417-by18aczt	263	21	the	the	DT
cord-023417-by18aczt	263	22	TNF	TNF	NNP
cord-023417-by18aczt	263	23	-	-	:
cord-023417-by18aczt	263	24	a	a	DT
cord-023417-by18aczt	263	25	response	response	NN
cord-023417-by18aczt	263	26	.	.	.
cord-023417-by18aczt	264	1	The	the	DT
cord-023417-by18aczt	264	2	TNF	TNF	NNP
cord-023417-by18aczt	264	3	-	-	:
cord-023417-by18aczt	264	4	a	a	DT
cord-023417-by18aczt	264	5	response	response	NN
cord-023417-by18aczt	264	6	peaked	peak	VBD
cord-023417-by18aczt	264	7	between	between	IN
cord-023417-by18aczt	264	8	3	3	CD
cord-023417-by18aczt	264	9	and	and	CC
cord-023417-by18aczt	264	10	4	4	CD
cord-023417-by18aczt	264	11	h	h	NN
cord-023417-by18aczt	264	12	at	at	IN
cord-023417-by18aczt	264	13	38.5	38.5	CD
cord-023417-by18aczt	264	14	C.	C.	NNP
cord-023417-by18aczt	264	15	A	A	NNP
cord-023417-by18aczt	264	16	dose	dose	NN
cord-023417-by18aczt	264	17	in	in	IN
cord-023417-by18aczt	264	18	the	the	DT
cord-023417-by18aczt	264	19	range	range	NN
cord-023417-by18aczt	264	20	of	of	IN
cord-023417-by18aczt	264	21	5	5	CD
cord-023417-by18aczt	264	22	-	-	SYM
cord-023417-by18aczt	264	23	10	10	CD
cord-023417-by18aczt	264	24	g	g	NN
cord-023417-by18aczt	264	25	of	of	IN
cord-023417-by18aczt	264	26	E.	E.	NNP
cord-023417-by18aczt	264	27	coli	coli	NNS
cord-023417-by18aczt	264	28	lipopolysaccharide	lipopolysaccharide	NN
cord-023417-by18aczt	264	29	(	(	-LRB-
cord-023417-by18aczt	264	30	LPS)/ml	lps)/ml	CD
cord-023417-by18aczt	264	31	whole	whole	JJ
cord-023417-by18aczt	264	32	blood	blood	NN
cord-023417-by18aczt	264	33	was	be	VBD
cord-023417-by18aczt	264	34	found	find	VBN
cord-023417-by18aczt	264	35	to	to	TO
cord-023417-by18aczt	264	36	give	give	VB
cord-023417-by18aczt	264	37	the	the	DT
cord-023417-by18aczt	264	38	maximum	maximum	JJ
cord-023417-by18aczt	264	39	TNF	TNF	NNP
cord-023417-by18aczt	264	40	-	-	:
cord-023417-by18aczt	264	41	a	a	DT
cord-023417-by18aczt	264	42	response	response	NN
cord-023417-by18aczt	264	43	.	.	.
cord-023417-by18aczt	265	1	Thirty	thirty	CD
cord-023417-by18aczt	265	2	-	-	HYPH
cord-023417-by18aczt	265	3	eight	eight	CD
cord-023417-by18aczt	265	4	Danish	Danish	NNP
cord-023417-by18aczt	265	5	-	-	HYPH
cord-023417-by18aczt	265	6	Holstein	Holstein	NNP
cord-023417-by18aczt	265	7	dairy	dairy	NN
cord-023417-by18aczt	265	8	cows	cow	NNS
cord-023417-by18aczt	265	9	were	be	VBD
cord-023417-by18aczt	265	10	investigated	investigate	VBN
cord-023417-by18aczt	265	11	for	for	IN
cord-023417-by18aczt	265	12	their	-PRON-	PRP$
cord-023417-by18aczt	265	13	TNF	TNF	NNP
cord-023417-by18aczt	265	14	-	-	:
cord-023417-by18aczt	265	15	a	a	DT
cord-023417-by18aczt	265	16	responsiveness	responsiveness	NN
cord-023417-by18aczt	265	17	ex	ex	FW
cord-023417-by18aczt	265	18	vivo	vivo	NN
cord-023417-by18aczt	265	19	in	in	IN
cord-023417-by18aczt	265	20	the	the	DT
cord-023417-by18aczt	265	21	periparturient	periparturient	JJ
cord-023417-by18aczt	265	22	period	period	NN
cord-023417-by18aczt	265	23	.	.	.
cord-023417-by18aczt	266	1	Heparin	Heparin	NNP
cord-023417-by18aczt	266	2	-	-	HYPH
cord-023417-by18aczt	266	3	stabilized	stabilize	VBN
cord-023417-by18aczt	266	4	blood	blood	NN
cord-023417-by18aczt	266	5	samples	sample	NNS
cord-023417-by18aczt	266	6	were	be	VBD
cord-023417-by18aczt	266	7	collected	collect	VBN
cord-023417-by18aczt	266	8	seven	seven	CD
cord-023417-by18aczt	266	9	times	time	NNS
cord-023417-by18aczt	266	10	over	over	IN
cord-023417-by18aczt	266	11	a	a	DT
cord-023417-by18aczt	266	12	period	period	NN
cord-023417-by18aczt	266	13	of	of	IN
cord-023417-by18aczt	266	14	4	4	CD
cord-023417-by18aczt	266	15	months	month	NNS
cord-023417-by18aczt	266	16	(	(	-LRB-
cord-023417-by18aczt	266	17	weeks	week	NNS
cord-023417-by18aczt	266	18	À3	à3	CD
cord-023417-by18aczt	266	19	,	,	,
cord-023417-by18aczt	266	20	À1	À1	NNP
cord-023417-by18aczt	266	21	,	,	,
cord-023417-by18aczt	266	22	2	2	CD
cord-023417-by18aczt	266	23	,	,	,
cord-023417-by18aczt	266	24	3	3	CD
cord-023417-by18aczt	266	25	,	,	,
cord-023417-by18aczt	266	26	5	5	CD
cord-023417-by18aczt	266	27	,	,	,
cord-023417-by18aczt	266	28	9	9	CD
cord-023417-by18aczt	266	29	and	and	CC
cord-023417-by18aczt	266	30	13	13	CD
cord-023417-by18aczt	266	31	around	around	IN
cord-023417-by18aczt	266	32	calving	calving	NN
cord-023417-by18aczt	266	33	)	)	-RRB-
cord-023417-by18aczt	266	34	and	and	CC
cord-023417-by18aczt	266	35	stimulated	stimulate	VBD
cord-023417-by18aczt	266	36	with	with	IN
cord-023417-by18aczt	266	37	5	5	CD
cord-023417-by18aczt	266	38	g	g	NN
cord-023417-by18aczt	266	39	/	/	SYM
cord-023417-by18aczt	266	40	ml	ml	NN
cord-023417-by18aczt	266	41	of	of	IN
cord-023417-by18aczt	266	42	E.	E.	NNP
cord-023417-by18aczt	266	43	coli	coli	VBZ
cord-023417-by18aczt	266	44	LPS	lp	NNS
cord-023417-by18aczt	266	45	.	.	.
cord-023417-by18aczt	267	1	Indeed	indeed	RB
cord-023417-by18aczt	267	2	,	,	,
cord-023417-by18aczt	267	3	fluctuations	fluctuation	NNS
cord-023417-by18aczt	267	4	in	in	IN
cord-023417-by18aczt	267	5	the	the	DT
cord-023417-by18aczt	267	6	TNF	TNF	NNP
cord-023417-by18aczt	267	7	-	-	:
cord-023417-by18aczt	267	8	a	a	DT
cord-023417-by18aczt	267	9	responsiveness	responsiveness	NN
cord-023417-by18aczt	267	10	occurred	occur	VBD
cord-023417-by18aczt	267	11	over	over	IN
cord-023417-by18aczt	267	12	time	time	NN
cord-023417-by18aczt	267	13	.	.	.
cord-023417-by18aczt	268	1	Moreover	moreover	RB
cord-023417-by18aczt	268	2	,	,	,
cord-023417-by18aczt	268	3	the	the	DT
cord-023417-by18aczt	268	4	mean	mean	JJ
cord-023417-by18aczt	268	5	TNF	TNF	NNP
cord-023417-by18aczt	268	6	-	-	:
cord-023417-by18aczt	268	7	a	a	DT
cord-023417-by18aczt	268	8	responsiveness	responsiveness	NN
cord-023417-by18aczt	268	9	of	of	IN
cord-023417-by18aczt	268	10	38	38	CD
cord-023417-by18aczt	268	11	cows	cow	NNS
cord-023417-by18aczt	268	12	was	be	VBD
cord-023417-by18aczt	268	13	found	find	VBN
cord-023417-by18aczt	268	14	to	to	TO
cord-023417-by18aczt	268	15	be	be	VB
cord-023417-by18aczt	268	16	significantly	significantly	RB
cord-023417-by18aczt	268	17	increased	increase	VBN
cord-023417-by18aczt	268	18	(	(	-LRB-
cord-023417-by18aczt	268	19	P	p	NN
cord-023417-by18aczt	268	20	<	<	XX
cord-023417-by18aczt	268	21	0.001	0.001	CD
cord-023417-by18aczt	268	22	)	)	-RRB-
cord-023417-by18aczt	268	23	in	in	IN
cord-023417-by18aczt	268	24	the	the	DT
cord-023417-by18aczt	268	25	weeks	week	NNS
cord-023417-by18aczt	268	26	close	close	JJ
cord-023417-by18aczt	268	27	to	to	IN
cord-023417-by18aczt	268	28	calving	calving	NN
cord-023417-by18aczt	268	29	.	.	.
cord-023417-by18aczt	269	1	However	however	RB
cord-023417-by18aczt	269	2	,	,	,
cord-023417-by18aczt	269	3	in	in	IN
cord-023417-by18aczt	269	4	the	the	DT
cord-023417-by18aczt	269	5	more	more	RBR
cord-023417-by18aczt	269	6	stabile	stabile	JJ
cord-023417-by18aczt	269	7	physiological	physiological	JJ
cord-023417-by18aczt	269	8	periods	period	NNS
cord-023417-by18aczt	269	9	,	,	,
cord-023417-by18aczt	269	10	some	some	DT
cord-023417-by18aczt	269	11	cows	cow	NNS
cord-023417-by18aczt	269	12	had	have	VBD
cord-023417-by18aczt	269	13	a	a	DT
cord-023417-by18aczt	269	14	consistently	consistently	RB
cord-023417-by18aczt	269	15	low	low	JJ
cord-023417-by18aczt	269	16	TNF	tnf	NN
cord-023417-by18aczt	269	17	-	-	:
cord-023417-by18aczt	269	18	a	a	DT
cord-023417-by18aczt	269	19	response	response	NN
cord-023417-by18aczt	269	20	,	,	,
cord-023417-by18aczt	269	21	whereas	whereas	IN
cord-023417-by18aczt	269	22	others	other	NNS
cord-023417-by18aczt	269	23	had	have	VBD
cord-023417-by18aczt	269	24	high	high	JJ
cord-023417-by18aczt	269	25	a	a	DT
cord-023417-by18aczt	269	26	TNF	TNF	NNP
cord-023417-by18aczt	269	27	-	-	:
cord-023417-by18aczt	269	28	a	a	DT
cord-023417-by18aczt	269	29	response	response	NN
cord-023417-by18aczt	269	30	.	.	.
cord-023417-by18aczt	270	1	We	-PRON-	PRP
cord-023417-by18aczt	270	2	are	be	VBP
cord-023417-by18aczt	270	3	currently	currently	RB
cord-023417-by18aczt	270	4	investigating	investigate	VBG
cord-023417-by18aczt	270	5	whether	whether	IN
cord-023417-by18aczt	270	6	high	high	JJ
cord-023417-by18aczt	270	7	and	and	CC
cord-023417-by18aczt	270	8	low	low	JJ
cord-023417-by18aczt	270	9	TNF	tnf	NN
cord-023417-by18aczt	270	10	-	-	:
cord-023417-by18aczt	270	11	a	a	DT
cord-023417-by18aczt	270	12	responders	responder	NNS
cord-023417-by18aczt	270	13	to	to	IN
cord-023417-by18aczt	270	14	E.	E.	NNP
cord-023417-by18aczt	270	15	coli	coli	VBZ
cord-023417-by18aczt	270	16	LPS	LPS	NNP
cord-023417-by18aczt	270	17	also	also	RB
cord-023417-by18aczt	270	18	exist	exist	VBP
cord-023417-by18aczt	270	19	in	in	IN
cord-023417-by18aczt	270	20	dairy	dairy	NN
cord-023417-by18aczt	270	21	cows	cow	NNS
cord-023417-by18aczt	270	22	in	in	IN
cord-023417-by18aczt	270	23	vivo	vivo	NN
cord-023417-by18aczt	270	24	.	.	.
cord-023417-by18aczt	271	1	Moreover	moreover	RB
cord-023417-by18aczt	271	2	,	,	,
cord-023417-by18aczt	271	3	the	the	DT
cord-023417-by18aczt	271	4	importance	importance	NN
cord-023417-by18aczt	271	5	of	of	IN
cord-023417-by18aczt	271	6	TNF	TNF	NNP
cord-023417-by18aczt	271	7	-	-	:
cord-023417-by18aczt	271	8	a	a	DT
cord-023417-by18aczt	271	9	responsiveness	responsiveness	NN
cord-023417-by18aczt	271	10	ex	ex	FW
cord-023417-by18aczt	271	11	vivo	vivo	NN
cord-023417-by18aczt	271	12	to	to	IN
cord-023417-by18aczt	271	13	dairy	dairy	NN
cord-023417-by18aczt	271	14	cows	cow	NNS
cord-023417-by18aczt	271	15	'	'	POS
cord-023417-by18aczt	271	16	susceptibility	susceptibility	NN
cord-023417-by18aczt	271	17	and	and	CC
cord-023417-by18aczt	271	18	clinical	clinical	JJ
cord-023417-by18aczt	271	19	response	response	NN
cord-023417-by18aczt	271	20	to	to	IN
cord-023417-by18aczt	271	21	experimental	experimental	JJ
cord-023417-by18aczt	271	22	E.	E.	NNP
cord-023417-by18aczt	271	23	coli	coli	VBZ
cord-023417-by18aczt	271	24	infections	infection	NNS
cord-023417-by18aczt	271	25	in	in	IN
cord-023417-by18aczt	271	26	the	the	DT
cord-023417-by18aczt	271	27	udder	udder	NN
cord-023417-by18aczt	271	28	is	be	VBZ
cord-023417-by18aczt	271	29	being	be	VBG
cord-023417-by18aczt	271	30	investigated	investigate	VBN
cord-023417-by18aczt	271	31	.	.	.
cord-023417-by18aczt	272	1	Coelomic	Coelomic	NNP
cord-023417-by18aczt	272	2	cytolytic	cytolytic	JJ
cord-023417-by18aczt	272	3	factor	factor	NN
cord-023417-by18aczt	272	4	(	(	-LRB-
cord-023417-by18aczt	272	5	CCF	CCF	NNP
cord-023417-by18aczt	272	6	)	)	-RRB-
cord-023417-by18aczt	272	7	is	be	VBZ
cord-023417-by18aczt	272	8	a	a	DT
cord-023417-by18aczt	272	9	42	42	CD
cord-023417-by18aczt	272	10	kDa	kDa	NNP
cord-023417-by18aczt	272	11	invertebrate	invertebrate	NN
cord-023417-by18aczt	272	12	pattern	pattern	NN
cord-023417-by18aczt	272	13	recognition	recognition	NN
cord-023417-by18aczt	272	14	molecule	molecule	NN
cord-023417-by18aczt	272	15	isolated	isolate	VBN
cord-023417-by18aczt	272	16	from	from	IN
cord-023417-by18aczt	272	17	the	the	DT
cord-023417-by18aczt	272	18	coelomic	coelomic	NNP
cord-023417-by18aczt	272	19	fluid	fluid	NN
cord-023417-by18aczt	272	20	of	of	IN
cord-023417-by18aczt	272	21	the	the	DT
cord-023417-by18aczt	272	22	earthworm	earthworm	NN
cord-023417-by18aczt	272	23	Eisenia	Eisenia	NNP
cord-023417-by18aczt	272	24	foetida	foetida	NNP
cord-023417-by18aczt	272	25	(	(	-LRB-
cord-023417-by18aczt	272	26	Oligochaeta	Oligochaeta	NNP
cord-023417-by18aczt	272	27	,	,	,
cord-023417-by18aczt	272	28	Annelida	Annelida	NNP
cord-023417-by18aczt	272	29	)	)	-RRB-
cord-023417-by18aczt	272	30	.	.	.
cord-023417-by18aczt	273	1	CCF	CCF	NNP
cord-023417-by18aczt	273	2	displays	display	VBZ
cord-023417-by18aczt	273	3	a	a	DT
cord-023417-by18aczt	273	4	number	number	NN
cord-023417-by18aczt	273	5	of	of	IN
cord-023417-by18aczt	273	6	similarities	similarity	NNS
cord-023417-by18aczt	273	7	with	with	IN
cord-023417-by18aczt	273	8	the	the	DT
cord-023417-by18aczt	273	9	mammalian	mammalian	JJ
cord-023417-by18aczt	273	10	cytokine	cytokine	NN
cord-023417-by18aczt	273	11	tumour	tumour	NN
cord-023417-by18aczt	273	12	necrosis	necrosis	NN
cord-023417-by18aczt	273	13	factor	factor	NN
cord-023417-by18aczt	273	14	-	-	:
cord-023417-by18aczt	273	15	a	a	NN
cord-023417-by18aczt	273	16	(	(	-LRB-
cord-023417-by18aczt	273	17	TNFa	TNFa	NNP
cord-023417-by18aczt	273	18	)	)	-RRB-
cord-023417-by18aczt	273	19	as	as	IN
cord-023417-by18aczt	273	20	a	a	DT
cord-023417-by18aczt	273	21	result	result	NN
cord-023417-by18aczt	273	22	of	of	IN
cord-023417-by18aczt	273	23	a	a	DT
cord-023417-by18aczt	273	24	shared	shared	JJ
cord-023417-by18aczt	273	25	N	N	NNP
cord-023417-by18aczt	273	26	,	,	,
cord-023417-by18aczt	273	27	N	n	CD
cord-023417-by18aczt	273	28	0	0	CD
cord-023417-by18aczt	273	29	-diacetylchitobiose	-diacetylchitobiose	HYPH
cord-023417-by18aczt	273	30	lectin	lectin	NN
cord-023417-by18aczt	273	31	-	-	HYPH
cord-023417-by18aczt	273	32	like	like	JJ
cord-023417-by18aczt	273	33	domain	domain	NN
cord-023417-by18aczt	273	34	.	.	.
cord-023417-by18aczt	274	1	However	however	RB
cord-023417-by18aczt	274	2	,	,	,
cord-023417-by18aczt	274	3	these	these	DT
cord-023417-by18aczt	274	4	similarities	similarity	NNS
cord-023417-by18aczt	274	5	are	be	VBP
cord-023417-by18aczt	274	6	solely	solely	RB
cord-023417-by18aczt	274	7	functional	functional	JJ
cord-023417-by18aczt	274	8	and	and	CC
cord-023417-by18aczt	274	9	are	be	VBP
cord-023417-by18aczt	274	10	not	not	RB
cord-023417-by18aczt	274	11	based	base	VBN
cord-023417-by18aczt	274	12	on	on	IN
cord-023417-by18aczt	274	13	any	any	DT
cord-023417-by18aczt	274	14	(	(	-LRB-
cord-023417-by18aczt	274	15	DNA	dna	NN
cord-023417-by18aczt	274	16	or	or	CC
cord-023417-by18aczt	274	17	amino	amino	NN
cord-023417-by18aczt	274	18	acid	acid	NN
cord-023417-by18aczt	274	19	)	)	-RRB-
cord-023417-by18aczt	274	20	sequence	sequence	NN
cord-023417-by18aczt	274	21	homology	homology	NN
cord-023417-by18aczt	274	22	,	,	,
cord-023417-by18aczt	274	23	thus	thus	RB
cord-023417-by18aczt	274	24	suggesting	suggest	VBG
cord-023417-by18aczt	274	25	a	a	DT
cord-023417-by18aczt	274	26	form	form	NN
cord-023417-by18aczt	274	27	of	of	IN
cord-023417-by18aczt	274	28	convergent	convergent	JJ
cord-023417-by18aczt	274	29	evolution	evolution	NN
cord-023417-by18aczt	274	30	.	.	.
cord-023417-by18aczt	275	1	In	in	IN
cord-023417-by18aczt	275	2	particular	particular	JJ
cord-023417-by18aczt	275	3	,	,	,
cord-023417-by18aczt	275	4	the	the	DT
cord-023417-by18aczt	275	5	lectin	lectin	NN
cord-023417-by18aczt	275	6	-	-	HYPH
cord-023417-by18aczt	275	7	like	like	JJ
cord-023417-by18aczt	275	8	domain	domain	NN
cord-023417-by18aczt	275	9	of	of	IN
cord-023417-by18aczt	275	10	TNF	TNF	NNP
cord-023417-by18aczt	275	11	-	-	:
cord-023417-by18aczt	275	12	a	a	NNP
cord-023417-by18aczt	275	13	has	have	VBZ
cord-023417-by18aczt	275	14	been	be	VBN
cord-023417-by18aczt	275	15	shown	show	VBN
cord-023417-by18aczt	275	16	to	to	TO
cord-023417-by18aczt	275	17	induce	induce	VB
cord-023417-by18aczt	275	18	membrane	membrane	NN
cord-023417-by18aczt	275	19	depolarization	depolarization	NN
cord-023417-by18aczt	275	20	in	in	IN
cord-023417-by18aczt	275	21	various	various	JJ
cord-023417-by18aczt	275	22	mammalian	mammalian	JJ
cord-023417-by18aczt	275	23	cell	cell	NN
cord-023417-by18aczt	275	24	types	type	NNS
cord-023417-by18aczt	275	25	,	,	,
cord-023417-by18aczt	275	26	through	through	IN
cord-023417-by18aczt	275	27	interactions	interaction	NNS
cord-023417-by18aczt	275	28	with	with	IN
cord-023417-by18aczt	275	29	endogenous	endogenous	JJ
cord-023417-by18aczt	275	30	amiloride	amiloride	NN
cord-023417-by18aczt	275	31	-	-	HYPH
cord-023417-by18aczt	275	32	sensitive	sensitive	JJ
cord-023417-by18aczt	275	33	ion	ion	NN
cord-023417-by18aczt	275	34	channels	channel	NNS
cord-023417-by18aczt	275	35	.	.	.
cord-023417-by18aczt	276	1	This	this	DT
cord-023417-by18aczt	276	2	nonreceptor	nonreceptor	RB
cord-023417-by18aczt	276	3	-	-	HYPH
cord-023417-by18aczt	276	4	mediated	mediate	VBN
cord-023417-by18aczt	276	5	activity	activity	NN
cord-023417-by18aczt	276	6	of	of	IN
cord-023417-by18aczt	276	7	TNF	TNF	NNP
cord-023417-by18aczt	276	8	-	-	:
cord-023417-by18aczt	276	9	a	a	NNP
cord-023417-by18aczt	276	10	has	have	VBZ
cord-023417-by18aczt	276	11	been	be	VBN
cord-023417-by18aczt	276	12	reported	report	VBN
cord-023417-by18aczt	276	13	to	to	TO
cord-023417-by18aczt	276	14	be	be	VB
cord-023417-by18aczt	276	15	involved	involve	VBN
cord-023417-by18aczt	276	16	in	in	IN
cord-023417-by18aczt	276	17	the	the	DT
cord-023417-by18aczt	276	18	resorption	resorption	NN
cord-023417-by18aczt	276	19	of	of	IN
cord-023417-by18aczt	276	20	oedema	oedema	NN
cord-023417-by18aczt	276	21	.	.	.
cord-023417-by18aczt	277	1	Likewise	likewise	RB
cord-023417-by18aczt	277	2	,	,	,
cord-023417-by18aczt	277	3	the	the	DT
cord-023417-by18aczt	277	4	lectin	lectin	NN
cord-023417-by18aczt	277	5	-	-	HYPH
cord-023417-by18aczt	277	6	like	like	JJ
cord-023417-by18aczt	277	7	domain	domain	NN
cord-023417-by18aczt	277	8	of	of	IN
cord-023417-by18aczt	277	9	CCF	CCF	NNP
cord-023417-by18aczt	277	10	also	also	RB
cord-023417-by18aczt	277	11	induces	induce	VBZ
cord-023417-by18aczt	277	12	membrane	membrane	NN
cord-023417-by18aczt	277	13	depolarization	depolarization	NN
cord-023417-by18aczt	277	14	in	in	IN
cord-023417-by18aczt	277	15	mammalian	mammalian	JJ
cord-023417-by18aczt	277	16	cells	cell	NNS
cord-023417-by18aczt	277	17	.	.	.
cord-023417-by18aczt	278	1	Here	here	RB
cord-023417-by18aczt	278	2	,	,	,
cord-023417-by18aczt	278	3	we	-PRON-	PRP
cord-023417-by18aczt	278	4	show	show	VBP
cord-023417-by18aczt	278	5	that	that	IN
cord-023417-by18aczt	278	6	CCF	CCF	NNP
cord-023417-by18aczt	278	7	appears	appear	VBZ
cord-023417-by18aczt	278	8	to	to	TO
cord-023417-by18aczt	278	9	be	be	VB
cord-023417-by18aczt	278	10	able	able	JJ
cord-023417-by18aczt	278	11	to	to	TO
cord-023417-by18aczt	278	12	induce	induce	VB
cord-023417-by18aczt	278	13	oedema	oedema	NN
cord-023417-by18aczt	278	14	resorption	resorption	NN
cord-023417-by18aczt	278	15	in	in	IN
cord-023417-by18aczt	278	16	an	an	DT
cord-023417-by18aczt	278	17	alveolar	alveolar	JJ
cord-023417-by18aczt	278	18	epithelial	epithelial	JJ
cord-023417-by18aczt	278	19	cell	cell	NN
cord-023417-by18aczt	278	20	line	line	NN
cord-023417-by18aczt	278	21	through	through	IN
cord-023417-by18aczt	278	22	its	-PRON-	PRP$
cord-023417-by18aczt	278	23	lectin	lectin	NN
cord-023417-by18aczt	278	24	-	-	HYPH
cord-023417-by18aczt	278	25	like	like	JJ
cord-023417-by18aczt	278	26	domain	domain	NN
cord-023417-by18aczt	278	27	.	.	.
cord-023417-by18aczt	279	1	This	this	DT
cord-023417-by18aczt	279	2	lectin	lectin	NN
cord-023417-by18aczt	279	3	-	-	HYPH
cord-023417-by18aczt	279	4	like	like	JJ
cord-023417-by18aczt	279	5	domain	domain	NN
cord-023417-by18aczt	279	6	of	of	IN
cord-023417-by18aczt	279	7	CCF	CCF	NNP
cord-023417-by18aczt	279	8	interacts	interact	VBZ
cord-023417-by18aczt	279	9	(	(	-LRB-
cord-023417-by18aczt	279	10	directly	directly	RB
cord-023417-by18aczt	279	11	or	or	CC
cord-023417-by18aczt	279	12	indirectly	indirectly	RB
cord-023417-by18aczt	279	13	)	)	-RRB-
cord-023417-by18aczt	279	14	with	with	IN
cord-023417-by18aczt	279	15	endogenous	endogenous	JJ
cord-023417-by18aczt	279	16	sodium	sodium	NN
cord-023417-by18aczt	279	17	and/or	and/or	CC
cord-023417-by18aczt	279	18	chloride	chloride	NN
cord-023417-by18aczt	279	19	channels	channel	NNS
cord-023417-by18aczt	279	20	,	,	,
cord-023417-by18aczt	279	21	and	and	CC
cord-023417-by18aczt	279	22	not	not	RB
cord-023417-by18aczt	279	23	potassium	potassium	NN
cord-023417-by18aczt	279	24	channels	channel	NNS
cord-023417-by18aczt	279	25	,	,	,
cord-023417-by18aczt	279	26	on	on	IN
cord-023417-by18aczt	279	27	mammalian	mammalian	JJ
cord-023417-by18aczt	279	28	cells	cell	NNS
cord-023417-by18aczt	279	29	.	.	.
cord-023417-by18aczt	280	1	Additionally	additionally	RB
cord-023417-by18aczt	280	2	,	,	,
cord-023417-by18aczt	280	3	we	-PRON-	PRP
cord-023417-by18aczt	280	4	suggest	suggest	VBP
cord-023417-by18aczt	280	5	that	that	IN
cord-023417-by18aczt	280	6	the	the	DT
cord-023417-by18aczt	280	7	JNK	JNK	NNP
cord-023417-by18aczt	280	8	/	/	SYM
cord-023417-by18aczt	280	9	SAPK	SAPK	NNP
cord-023417-by18aczt	280	10	and	and	CC
cord-023417-by18aczt	280	11	Erk1/2	Erk1/2	NNP
cord-023417-by18aczt	280	12	pathways	pathway	NNS
cord-023417-by18aczt	280	13	are	be	VBP
cord-023417-by18aczt	280	14	involved	involve	VBN
cord-023417-by18aczt	280	15	in	in	IN
cord-023417-by18aczt	280	16	CCF	CCF	NNP
cord-023417-by18aczt	280	17	-	-	HYPH
cord-023417-by18aczt	280	18	induced	induce	VBN
cord-023417-by18aczt	280	19	macrophage	macrophage	NN
cord-023417-by18aczt	280	20	activation	activation	NN
cord-023417-by18aczt	280	21	.	.	.
cord-023417-by18aczt	281	1	These	these	DT
cord-023417-by18aczt	281	2	results	result	NNS
cord-023417-by18aczt	281	3	further	further	RB
cord-023417-by18aczt	281	4	establish	establish	VBP
cord-023417-by18aczt	281	5	the	the	DT
cord-023417-by18aczt	281	6	functional	functional	JJ
cord-023417-by18aczt	281	7	analogy	analogy	NN
cord-023417-by18aczt	281	8	between	between	IN
cord-023417-by18aczt	281	9	an	an	DT
cord-023417-by18aczt	281	10	invertebrate	invertebrate	JJ
cord-023417-by18aczt	281	11	pattern	pattern	NN
cord-023417-by18aczt	281	12	recognition	recognition	NN
cord-023417-by18aczt	281	13	molecule	molecule	NN
cord-023417-by18aczt	281	14	and	and	CC
cord-023417-by18aczt	281	15	a	a	DT
cord-023417-by18aczt	281	16	mammalian	mammalian	JJ
cord-023417-by18aczt	281	17	cytokine	cytokine	NN
cord-023417-by18aczt	281	18	and	and	CC
cord-023417-by18aczt	281	19	,	,	,
cord-023417-by18aczt	281	20	from	from	IN
cord-023417-by18aczt	281	21	a	a	DT
cord-023417-by18aczt	281	22	more	more	RBR
cord-023417-by18aczt	281	23	applied	applied	JJ
cord-023417-by18aczt	281	24	point	point	NN
cord-023417-by18aczt	281	25	of	of	IN
cord-023417-by18aczt	281	26	view	view	NN
cord-023417-by18aczt	281	27	,	,	,
cord-023417-by18aczt	281	28	suggest	suggest	VBP
cord-023417-by18aczt	281	29	the	the	DT
cord-023417-by18aczt	281	30	possibility	possibility	NN
cord-023417-by18aczt	281	31	of	of	IN
cord-023417-by18aczt	281	32	utilizing	utilize	VBG
cord-023417-by18aczt	281	33	CCF	CCF	NNP
cord-023417-by18aczt	281	34	in	in	IN
cord-023417-by18aczt	281	35	the	the	DT
cord-023417-by18aczt	281	36	treatment	treatment	NN
cord-023417-by18aczt	281	37	of	of	IN
cord-023417-by18aczt	281	38	oedema	oedema	NN
cord-023417-by18aczt	281	39	.	.	.
cord-023417-by18aczt	282	1	Release	Release	NNP
cord-023417-by18aczt	282	2	of	of	IN
cord-023417-by18aczt	282	3	sVEGF	svegf	NN
cord-023417-by18aczt	282	4	and	and	CC
cord-023417-by18aczt	282	5	sVEGFR1	svegfr1	NN
cord-023417-by18aczt	282	6	from	from	IN
cord-023417-by18aczt	282	7	White	White	NNP
cord-023417-by18aczt	282	8	Blood	Blood	NNP
cord-023417-by18aczt	282	9	Cells	Cells	NNPS
cord-023417-by18aczt	282	10	and	and	CC
cord-023417-by18aczt	282	11	Platelets	platelet	NNS
cord-023417-by18aczt	282	12	During	during	IN
cord-023417-by18aczt	282	13	Surgery	surgery	NN
cord-023417-by18aczt	282	14	and	and	CC
cord-023417-by18aczt	282	15	Stimulation	stimulation	NN
cord-023417-by18aczt	282	16	with	with	IN
cord-023417-by18aczt	282	17	Bacterial	bacterial	JJ
cord-023417-by18aczt	282	18	Antigens	antigen	NNS
cord-023417-by18aczt	282	19	Introduction	introduction	NN
cord-023417-by18aczt	282	20	:	:	:
cord-023417-by18aczt	283	1	The	the	DT
cord-023417-by18aczt	283	2	influence	influence	NN
cord-023417-by18aczt	283	3	of	of	IN
cord-023417-by18aczt	283	4	surgery	surgery	NN
cord-023417-by18aczt	283	5	on	on	IN
cord-023417-by18aczt	283	6	release	release	NN
cord-023417-by18aczt	283	7	of	of	IN
cord-023417-by18aczt	283	8	soluble	soluble	JJ
cord-023417-by18aczt	283	9	vascular	vascular	JJ
cord-023417-by18aczt	283	10	endothelial	endothelial	JJ
cord-023417-by18aczt	283	11	growth	growth	NN
cord-023417-by18aczt	283	12	factor	factor	NN
cord-023417-by18aczt	283	13	(	(	-LRB-
cord-023417-by18aczt	283	14	sVEGF	sVEGF	NNP
cord-023417-by18aczt	283	15	)	)	-RRB-
cord-023417-by18aczt	283	16	and	and	CC
cord-023417-by18aczt	283	17	the	the	DT
cord-023417-by18aczt	283	18	soluble	soluble	JJ
cord-023417-by18aczt	283	19	vascular	vascular	JJ
cord-023417-by18aczt	283	20	endothelial	endothelial	JJ
cord-023417-by18aczt	283	21	growth	growth	NN
cord-023417-by18aczt	283	22	factor	factor	NN
cord-023417-by18aczt	283	23	inhibitory	inhibitory	JJ
cord-023417-by18aczt	283	24	receptor	receptor	NN
cord-023417-by18aczt	283	25	1	1	CD
cord-023417-by18aczt	283	26	(	(	-LRB-
cord-023417-by18aczt	283	27	sVEGFR1	sVEGFR1	NNP
cord-023417-by18aczt	283	28	)	)	-RRB-
cord-023417-by18aczt	283	29	is	be	VBZ
cord-023417-by18aczt	283	30	unknown	unknown	JJ
cord-023417-by18aczt	283	31	.	.	.
cord-023417-by18aczt	284	1	We	-PRON-	PRP
cord-023417-by18aczt	284	2	studied	study	VBD
cord-023417-by18aczt	284	3	the	the	DT
cord-023417-by18aczt	284	4	effect	effect	NN
cord-023417-by18aczt	284	5	of	of	IN
cord-023417-by18aczt	284	6	major	major	JJ
cord-023417-by18aczt	284	7	and	and	CC
cord-023417-by18aczt	284	8	minor	minor	JJ
cord-023417-by18aczt	284	9	surgery	surgery	NN
cord-023417-by18aczt	284	10	on	on	IN
cord-023417-by18aczt	284	11	potential	potential	JJ
cord-023417-by18aczt	284	12	variations	variation	NNS
cord-023417-by18aczt	284	13	in	in	IN
cord-023417-by18aczt	284	14	sVEGF	svegf	NN
cord-023417-by18aczt	284	15	and	and	CC
cord-023417-by18aczt	284	16	sVEGFR1	svegfr1	JJ
cord-023417-by18aczt	284	17	concentrations	concentration	NNS
cord-023417-by18aczt	284	18	in	in	IN
cord-023417-by18aczt	284	19	vivo	vivo	NN
cord-023417-by18aczt	284	20	and	and	CC
cord-023417-by18aczt	284	21	on	on	IN
cord-023417-by18aczt	284	22	bacterial	bacterial	JJ
cord-023417-by18aczt	284	23	antigen	antigen	NN
cord-023417-by18aczt	284	24	-	-	HYPH
cord-023417-by18aczt	284	25	induced	induce	VBN
cord-023417-by18aczt	284	26	release	release	NN
cord-023417-by18aczt	284	27	of	of	IN
cord-023417-by18aczt	284	28	sVEGF	sVEGF	NNP
cord-023417-by18aczt	284	29	and	and	CC
cord-023417-by18aczt	284	30	sVEGFR1	svegfr1	NN
cord-023417-by18aczt	284	31	from	from	IN
cord-023417-by18aczt	284	32	whole	whole	JJ
cord-023417-by18aczt	284	33	blood	blood	NN
cord-023417-by18aczt	284	34	in	in	IN
cord-023417-by18aczt	284	35	vitro	vitro	FW
cord-023417-by18aczt	284	36	.	.	.
cord-023417-by18aczt	285	1	Methods	method	NNS
cord-023417-by18aczt	285	2	:	:	:
cord-023417-by18aczt	285	3	Sixty	sixty	CD
cord-023417-by18aczt	285	4	-	-	HYPH
cord-023417-by18aczt	285	5	one	one	CD
cord-023417-by18aczt	285	6	patients	patient	NNS
cord-023417-by18aczt	285	7	with	with	IN
cord-023417-by18aczt	285	8	abdominal	abdominal	JJ
cord-023417-by18aczt	285	9	diseases	disease	NNS
cord-023417-by18aczt	285	10	undergoing	undergo	VBG
cord-023417-by18aczt	285	11	five	five	CD
cord-023417-by18aczt	285	12	different	different	JJ
cord-023417-by18aczt	285	13	surgical	surgical	JJ
cord-023417-by18aczt	285	14	procedures	procedure	NNS
cord-023417-by18aczt	285	15	were	be	VBD
cord-023417-by18aczt	285	16	included	include	VBN
cord-023417-by18aczt	285	17	.	.	.
cord-023417-by18aczt	286	1	Blood	blood	NN
cord-023417-by18aczt	286	2	samples	sample	NNS
cord-023417-by18aczt	286	3	were	be	VBD
cord-023417-by18aczt	286	4	drawn	draw	VBN
cord-023417-by18aczt	286	5	from	from	IN
cord-023417-by18aczt	286	6	anaesthetized	anaesthetized	JJ
cord-023417-by18aczt	286	7	patients	patient	NNS
cord-023417-by18aczt	286	8	before	before	IN
cord-023417-by18aczt	286	9	and	and	CC
cord-023417-by18aczt	286	10	after	after	IN
cord-023417-by18aczt	286	11	the	the	DT
cord-023417-by18aczt	286	12	operation	operation	NN
cord-023417-by18aczt	286	13	.	.	.
cord-023417-by18aczt	287	1	White	white	JJ
cord-023417-by18aczt	287	2	blood	blood	NN
cord-023417-by18aczt	287	3	cells	cell	NNS
cord-023417-by18aczt	287	4	and	and	CC
cord-023417-by18aczt	287	5	platelets	platelet	NNS
cord-023417-by18aczt	287	6	were	be	VBD
cord-023417-by18aczt	287	7	counted	count	VBN
cord-023417-by18aczt	287	8	,	,	,
cord-023417-by18aczt	287	9	and	and	CC
cord-023417-by18aczt	287	10	plasma	plasma	NN
cord-023417-by18aczt	287	11	sVEGF	svegf	NN
cord-023417-by18aczt	287	12	and	and	CC
cord-023417-by18aczt	287	13	sVEGFR1	sVEGFR1	NNP
cord-023417-by18aczt	287	14	was	be	VBD
cord-023417-by18aczt	287	15	determined	determine	VBN
cord-023417-by18aczt	287	16	by	by	IN
cord-023417-by18aczt	287	17	an	an	DT
cord-023417-by18aczt	287	18	ELISA	ELISA	NNP
cord-023417-by18aczt	287	19	method	method	NN
cord-023417-by18aczt	287	20	.	.	.
cord-023417-by18aczt	288	1	Whole	whole	JJ
cord-023417-by18aczt	288	2	blood	blood	NN
cord-023417-by18aczt	288	3	from	from	IN
cord-023417-by18aczt	288	4	each	each	DT
cord-023417-by18aczt	288	5	blood	blood	NN
cord-023417-by18aczt	288	6	sample	sample	NN
cord-023417-by18aczt	288	7	was	be	VBD
cord-023417-by18aczt	288	8	stimulated	stimulate	VBN
cord-023417-by18aczt	288	9	in	in	IN
cord-023417-by18aczt	288	10	vitro	vitro	FW
cord-023417-by18aczt	288	11	with	with	IN
cord-023417-by18aczt	288	12	bacteria	bacteria	NNS
cord-023417-by18aczt	288	13	-	-	HYPH
cord-023417-by18aczt	288	14	derived	derive	VBN
cord-023417-by18aczt	288	15	antigens	antigen	NNS
cord-023417-by18aczt	288	16	(	(	-LRB-
cord-023417-by18aczt	288	17	LPS	LPS	NNP
cord-023417-by18aczt	288	18	or	or	CC
cord-023417-by18aczt	288	19	protein	protein	NN
cord-023417-by18aczt	288	20	-	-	HYPH
cord-023417-by18aczt	288	21	A	a	NN
cord-023417-by18aczt	288	22	)	)	-RRB-
cord-023417-by18aczt	288	23	and	and	CC
cord-023417-by18aczt	288	24	sVEGF	svegf	NN
cord-023417-by18aczt	288	25	and	and	CC
cord-023417-by18aczt	288	26	sVEGFR1	svegfr1	JJ
cord-023417-by18aczt	288	27	levels	level	NNS
cord-023417-by18aczt	288	28	were	be	VBD
cord-023417-by18aczt	288	29	subsequently	subsequently	RB
cord-023417-by18aczt	288	30	determined	determine	VBN
cord-023417-by18aczt	288	31	in	in	IN
cord-023417-by18aczt	288	32	the	the	DT
cord-023417-by18aczt	288	33	supernatants	supernatant	NNS
cord-023417-by18aczt	288	34	.	.	.
cord-023417-by18aczt	289	1	Stimulation	stimulation	NN
cord-023417-by18aczt	289	2	with	with	IN
cord-023417-by18aczt	289	3	isotonic	isotonic	JJ
cord-023417-by18aczt	289	4	saline	saline	NN
cord-023417-by18aczt	289	5	served	serve	VBD
cord-023417-by18aczt	289	6	as	as	IN
cord-023417-by18aczt	289	7	control	control	NN
cord-023417-by18aczt	289	8	assay	assay	NN
cord-023417-by18aczt	289	9	.	.	.
cord-023417-by18aczt	289	10	 	 	_SP
cord-023417-by18aczt	290	1	Neither	neither	DT
cord-023417-by18aczt	290	2	sVEGF	svegf	NN
cord-023417-by18aczt	290	3	or	or	CC
cord-023417-by18aczt	290	4	sVEGFR1	svegfr1	NN
cord-023417-by18aczt	290	5	in	in	IN
cord-023417-by18aczt	290	6	plasma	plasma	NN
cord-023417-by18aczt	290	7	changed	change	VBN
cord-023417-by18aczt	290	8	during	during	IN
cord-023417-by18aczt	290	9	surgery	surgery	NN
cord-023417-by18aczt	290	10	.	.	.
cord-023417-by18aczt	291	1	In	in	IN
cord-023417-by18aczt	291	2	vitro	vitro	FW
cord-023417-by18aczt	291	3	stimulation	stimulation	NN
cord-023417-by18aczt	291	4	of	of	IN
cord-023417-by18aczt	291	5	blood	blood	NN
cord-023417-by18aczt	291	6	samples	sample	NNS
cord-023417-by18aczt	291	7	with	with	IN
cord-023417-by18aczt	291	8	bacteria	bacteria	NNS
cord-023417-by18aczt	291	9	-	-	HYPH
cord-023417-by18aczt	291	10	derived	derive	VBN
cord-023417-by18aczt	291	11	antigens	antigen	NNS
cord-023417-by18aczt	291	12	resulted	result	VBD
cord-023417-by18aczt	291	13	in	in	IN
cord-023417-by18aczt	291	14	a	a	DT
cord-023417-by18aczt	291	15	significant	significant	JJ
cord-023417-by18aczt	291	16	increase	increase	NN
cord-023417-by18aczt	291	17	in	in	IN
cord-023417-by18aczt	291	18	sVEGF	svegf	NN
cord-023417-by18aczt	292	1	(	(	-LRB-
cord-023417-by18aczt	292	2	P	p	NN
cord-023417-by18aczt	292	3	<	<	XX
cord-023417-by18aczt	292	4	0.0001	0.0001	CD
cord-023417-by18aczt	292	5	)	)	-RRB-
cord-023417-by18aczt	292	6	and	and	CC
cord-023417-by18aczt	292	7	a	a	DT
cord-023417-by18aczt	292	8	less	less	RBR
cord-023417-by18aczt	292	9	pronounced	pronounced	JJ
cord-023417-by18aczt	292	10	but	but	CC
cord-023417-by18aczt	292	11	still	still	RB
cord-023417-by18aczt	292	12	significant	significant	JJ
cord-023417-by18aczt	292	13	increase	increase	NN
cord-023417-by18aczt	292	14	in	in	IN
cord-023417-by18aczt	292	15	sVEGFR1	svegfr1	NN
cord-023417-by18aczt	292	16	.	.	.
cord-023417-by18aczt	293	1	Release	Release	NNP
cord-023417-by18aczt	293	2	of	of	IN
cord-023417-by18aczt	293	3	sVEGF	svegf	NN
cord-023417-by18aczt	293	4	due	due	IN
cord-023417-by18aczt	293	5	to	to	IN
cord-023417-by18aczt	293	6	stimulation	stimulation	NN
cord-023417-by18aczt	293	7	was	be	VBD
cord-023417-by18aczt	293	8	significantly	significantly	RB
cord-023417-by18aczt	293	9	higher	high	JJR
cord-023417-by18aczt	293	10	after	after	IN
cord-023417-by18aczt	293	11	the	the	DT
cord-023417-by18aczt	293	12	operation	operation	NN
cord-023417-by18aczt	293	13	(	(	-LRB-
cord-023417-by18aczt	293	14	nonsignificant	nonsignificant	JJ
cord-023417-by18aczt	293	15	)	)	-RRB-
cord-023417-by18aczt	293	16	,	,	,
cord-023417-by18aczt	293	17	whereas	whereas	IN
cord-023417-by18aczt	293	18	sVEGFR1	sVEGFR1	NNP
cord-023417-by18aczt	293	19	release	release	NN
cord-023417-by18aczt	293	20	remained	remain	VBD
cord-023417-by18aczt	293	21	largely	largely	RB
cord-023417-by18aczt	293	22	unchanged	unchanged	JJ
cord-023417-by18aczt	293	23	after	after	IN
cord-023417-by18aczt	293	24	surgery	surgery	NN
cord-023417-by18aczt	293	25	.	.	.
cord-023417-by18aczt	294	1	Correlation	correlation	NN
cord-023417-by18aczt	294	2	between	between	IN
cord-023417-by18aczt	294	3	bacterial	bacterial	JJ
cord-023417-by18aczt	294	4	antigen	antigen	NN
cord-023417-by18aczt	294	5	-	-	HYPH
cord-023417-by18aczt	294	6	induced	induce	VBN
cord-023417-by18aczt	294	7	release	release	NN
cord-023417-by18aczt	294	8	of	of	IN
cord-023417-by18aczt	294	9	sVEGF	sVEGF	NNP
cord-023417-by18aczt	294	10	and	and	CC
cord-023417-by18aczt	294	11	neutrophile	neutrophile	JJ
cord-023417-by18aczt	294	12	cell	cell	NN
cord-023417-by18aczt	294	13	count	count	NN
cord-023417-by18aczt	294	14	was	be	VBD
cord-023417-by18aczt	294	15	highly	highly	RB
cord-023417-by18aczt	294	16	significant	significant	JJ
cord-023417-by18aczt	294	17	(	(	-LRB-
cord-023417-by18aczt	294	18	P	p	NN
cord-023417-by18aczt	294	19	<	<	XX
cord-023417-by18aczt	294	20	0.0001	0.0001	CD
cord-023417-by18aczt	294	21	)	)	-RRB-
cord-023417-by18aczt	294	22	.	.	.
cord-023417-by18aczt	295	1	There	there	EX
cord-023417-by18aczt	295	2	was	be	VBD
cord-023417-by18aczt	295	3	no	no	DT
cord-023417-by18aczt	295	4	correlation	correlation	NN
cord-023417-by18aczt	295	5	between	between	IN
cord-023417-by18aczt	295	6	sVEGF	svegf	NN
cord-023417-by18aczt	295	7	and	and	CC
cord-023417-by18aczt	295	8	platelet	platelet	NN
cord-023417-by18aczt	295	9	cell	cell	NN
cord-023417-by18aczt	295	10	count	count	NN
cord-023417-by18aczt	295	11	,	,	,
cord-023417-by18aczt	295	12	and	and	CC
cord-023417-by18aczt	295	13	bacterial	bacterial	JJ
cord-023417-by18aczt	295	14	antigen	antigen	NN
cord-023417-by18aczt	295	15	-	-	HYPH
cord-023417-by18aczt	295	16	induced	induce	VBN
cord-023417-by18aczt	295	17	sVEGFR1	svegfr1	NN
cord-023417-by18aczt	295	18	release	release	NN
cord-023417-by18aczt	295	19	did	do	VBD
cord-023417-by18aczt	295	20	not	not	RB
cord-023417-by18aczt	295	21	correlate	correlate	VB
cord-023417-by18aczt	295	22	with	with	IN
cord-023417-by18aczt	295	23	counts	count	NNS
cord-023417-by18aczt	295	24	of	of	IN
cord-023417-by18aczt	295	25	neutrophils	neutrophil	NNS
cord-023417-by18aczt	295	26	and	and	CC
cord-023417-by18aczt	295	27	platelets	platelet	NNS
cord-023417-by18aczt	295	28	.	.	.
cord-023417-by18aczt	296	1	Conclusions	conclusion	NNS
cord-023417-by18aczt	296	2	:	:	:
cord-023417-by18aczt	297	1	Plasma	plasma	NN
cord-023417-by18aczt	297	2	sVEGF	svegf	NN
cord-023417-by18aczt	297	3	and	and	CC
cord-023417-by18aczt	297	4	sVEGFR1	svegfr1	NN
cord-023417-by18aczt	297	5	concentrations	concentration	NNS
cord-023417-by18aczt	297	6	did	do	VBD
cord-023417-by18aczt	297	7	not	not	RB
cord-023417-by18aczt	297	8	change	change	VB
cord-023417-by18aczt	297	9	during	during	IN
cord-023417-by18aczt	297	10	surgery	surgery	NN
cord-023417-by18aczt	297	11	.	.	.
cord-023417-by18aczt	298	1	In	in	IN
cord-023417-by18aczt	298	2	vitro	vitro	FW
cord-023417-by18aczt	298	3	bacterial	bacterial	JJ
cord-023417-by18aczt	298	4	stimulation	stimulation	NN
cord-023417-by18aczt	298	5	led	lead	VBD
cord-023417-by18aczt	298	6	to	to	IN
cord-023417-by18aczt	298	7	increased	increase	VBN
cord-023417-by18aczt	298	8	release	release	NN
cord-023417-by18aczt	298	9	of	of	IN
cord-023417-by18aczt	298	10	sVEGF	sVEGF	NNP
cord-023417-by18aczt	298	11	and	and	CC
cord-023417-by18aczt	298	12	sVEGFR1	sVEGFR1	NNP
cord-023417-by18aczt	298	13	,	,	,
cord-023417-by18aczt	298	14	which	which	WDT
cord-023417-by18aczt	298	15	was	be	VBD
cord-023417-by18aczt	298	16	not	not	RB
cord-023417-by18aczt	298	17	significantly	significantly	RB
cord-023417-by18aczt	298	18	amplified	amplify	VBN
cord-023417-by18aczt	298	19	during	during	IN
cord-023417-by18aczt	298	20	surgery	surgery	NN
cord-023417-by18aczt	298	21	and	and	CC
cord-023417-by18aczt	298	22	which	which	WDT
cord-023417-by18aczt	298	23	may	may	MD
cord-023417-by18aczt	298	24	be	be	VB
cord-023417-by18aczt	298	25	related	relate	VBN
cord-023417-by18aczt	298	26	to	to	IN
cord-023417-by18aczt	298	27	number	number	NN
cord-023417-by18aczt	298	28	of	of	IN
cord-023417-by18aczt	298	29	circulating	circulate	VBG
cord-023417-by18aczt	298	30	neutrophils	neutrophil	NNS
cord-023417-by18aczt	298	31	.	.	.
cord-023417-by18aczt	299	1	Natural	natural	JJ
cord-023417-by18aczt	299	2	Killer	Killer	NNP
cord-023417-by18aczt	299	3	Cell	Cell	NNP
cord-023417-by18aczt	299	4	Functions	Functions	NNPS
cord-023417-by18aczt	299	5	and	and	CC
cord-023417-by18aczt	299	6	Subsets	subset	NNS
cord-023417-by18aczt	300	1	After	after	IN
cord-023417-by18aczt	300	2	In	in	IN
cord-023417-by18aczt	300	3	Vitro	vitro	JJ
cord-023417-by18aczt	300	4	Stimulation	stimulation	NN
cord-023417-by18aczt	300	5	with	with	IN
cord-023417-by18aczt	300	6	IL-2	IL-2	NNP
cord-023417-by18aczt	300	7	and	and	CC
cord-023417-by18aczt	300	8	IL-12	IL-12	NNP
cord-023417-by18aczt	300	9	,	,	,
cord-023417-by18aczt	300	10	with	with	IN
cord-023417-by18aczt	300	11	Special	Special	NNP
cord-023417-by18aczt	300	12	Emphasis	Emphasis	NNP
cord-023417-by18aczt	300	13	on	on	IN
cord-023417-by18aczt	300	14	Intracellular	Intracellular	NNP
cord-023417-by18aczt	300	15	IFN	IFN	NNP
cord-023417-by18aczt	300	16	-	-	HYPH
cord-023417-by18aczt	300	17	g	g	NNP
cord-023417-by18aczt	300	18	and	and	CC
cord-023417-by18aczt	301	1	NK	NK	NNP
cord-023417-by18aczt	301	2	-	-	HYPH
cord-023417-by18aczt	301	3	Cell	Cell	NNP
cord-023417-by18aczt	301	4	Cytotoxicity	Cytotoxicity	NNP
cord-023417-by18aczt	301	5	R.	R.	NNP
cord-023417-by18aczt	301	6	Nyboe	Nyboe	NNP
cord-023417-by18aczt	301	7	,	,	,
cord-023417-by18aczt	301	8	1,2	1,2	CD
cord-023417-by18aczt	301	9	T.	T.	NNP
cord-023417-by18aczt	301	10	Rix	Rix	NNP
cord-023417-by18aczt	301	11	,	,	,
cord-023417-by18aczt	301	12	1,2	1,2	CD
cord-023417-by18aczt	301	13	J.	J.	NNP
cord-023417-by18aczt	301	14	Krog	Krog	NNP
cord-023417-by18aczt	301	15	,	,	,
cord-023417-by18aczt	301	16	1,2	1,2	CD
cord-023417-by18aczt	301	17	E.	E.	NNP
cord-023417-by18aczt	301	18	Tønnesen	Tønnesen	NNP
cord-023417-by18aczt	301	19	1	1	CD
cord-023417-by18aczt	301	20	&	&	CC
cord-023417-by18aczt	301	21	M.	M.	NNP
cord-023417-by18aczt	301	22	Hokland	Hokland	NNP
cord-023417-by18aczt	301	23	2	2	CD
cord-023417-by18aczt	301	24	1	1	CD
cord-023417-by18aczt	301	25	Department	Department	NNP
cord-023417-by18aczt	301	26	of	of	IN
cord-023417-by18aczt	301	27	Anaesthesiology	Anaesthesiology	NNP
cord-023417-by18aczt	301	28	and	and	CC
cord-023417-by18aczt	301	29	Intensive	Intensive	NNP
cord-023417-by18aczt	301	30	Care	Care	NNP
cord-023417-by18aczt	301	31	,	,	,
cord-023417-by18aczt	301	32	Aarhus	Aarhus	NNP
cord-023417-by18aczt	301	33	University	University	NNP
cord-023417-by18aczt	301	34	hospital	hospital	NN
cord-023417-by18aczt	301	35	,	,	,
cord-023417-by18aczt	301	36	and	and	CC
cord-023417-by18aczt	301	37	2	2	CD
cord-023417-by18aczt	301	38	Institute	Institute	NNP
cord-023417-by18aczt	301	39	of	of	IN
cord-023417-by18aczt	301	40	Medical	Medical	NNP
cord-023417-by18aczt	301	41	Microbiology	Microbiology	NNP
cord-023417-by18aczt	301	42	,	,	,
cord-023417-by18aczt	301	43	and	and	CC
cord-023417-by18aczt	301	44	Immunology	Immunology	NNP
cord-023417-by18aczt	301	45	,	,	,
cord-023417-by18aczt	301	46	University	University	NNP
cord-023417-by18aczt	301	47	of	of	IN
cord-023417-by18aczt	301	48	Aarhus	Aarhus	NNP
cord-023417-by18aczt	301	49	,	,	,
cord-023417-by18aczt	301	50	Aarhus	Aarhus	NNP
cord-023417-by18aczt	301	51	,	,	,
cord-023417-by18aczt	301	52	Denmark	Denmark	NNP
cord-023417-by18aczt	301	53	.	.	.
cord-023417-by18aczt	302	1	E	e	NN
cord-023417-by18aczt	302	2	-	-	NN
cord-023417-by18aczt	302	3	mail	mail	NN
cord-023417-by18aczt	302	4	:	:	:
cord-023417-by18aczt	303	1	rnsr@studmed.au.dk	rnsr@studmed.au.dk	NFP
cord-023417-by18aczt	303	2	Materials	material	NNS
cord-023417-by18aczt	303	3	and	and	CC
cord-023417-by18aczt	303	4	methods	method	NNS
cord-023417-by18aczt	303	5	:	:	:
cord-023417-by18aczt	303	6	Isolated	isolated	JJ
cord-023417-by18aczt	303	7	cryopreserved	cryopreserved	JJ
cord-023417-by18aczt	303	8	human	human	JJ
cord-023417-by18aczt	303	9	peripheral	peripheral	JJ
cord-023417-by18aczt	303	10	blood	blood	NN
cord-023417-by18aczt	303	11	mononuclear	mononuclear	NN
cord-023417-by18aczt	303	12	cells	cell	NNS
cord-023417-by18aczt	303	13	(	(	-LRB-
cord-023417-by18aczt	303	14	PBMCs	pbmc	NNS
cord-023417-by18aczt	303	15	)	)	-RRB-
cord-023417-by18aczt	303	16	were	be	VBD
cord-023417-by18aczt	303	17	stimulated	stimulate	VBN
cord-023417-by18aczt	303	18	with	with	IN
cord-023417-by18aczt	303	19	IL-2	IL-2	NNP
cord-023417-by18aczt	303	20	and	and	CC
cord-023417-by18aczt	303	21	IL-12	IL-12	NNP
cord-023417-by18aczt	303	22	.	.	.
cord-023417-by18aczt	304	1	This	this	DT
cord-023417-by18aczt	304	2	stimulation	stimulation	NN
cord-023417-by18aczt	304	3	has	have	VBZ
cord-023417-by18aczt	304	4	previously	previously	RB
cord-023417-by18aczt	304	5	been	be	VBN
cord-023417-by18aczt	304	6	shown	show	VBN
cord-023417-by18aczt	304	7	to	to	TO
cord-023417-by18aczt	304	8	activate	activate	VB
cord-023417-by18aczt	304	9	NK	NK	NNP
cord-023417-by18aczt	304	10	cells	cell	NNS
cord-023417-by18aczt	304	11	.	.	.
cord-023417-by18aczt	305	1	Cell	cell	NN
cord-023417-by18aczt	305	2	cytotoxicity	cytotoxicity	NN
cord-023417-by18aczt	305	3	was	be	VBD
cord-023417-by18aczt	305	4	measured	measure	VBN
cord-023417-by18aczt	305	5	by	by	IN
cord-023417-by18aczt	305	6	flow	flow	NN
cord-023417-by18aczt	305	7	cytometry	cytometry	NN
cord-023417-by18aczt	305	8	after	after	IN
cord-023417-by18aczt	305	9	incubation	incubation	NN
cord-023417-by18aczt	305	10	with	with	IN
cord-023417-by18aczt	305	11	k562	k562	NN
cord-023417-by18aczt	305	12	cells	cell	NNS
cord-023417-by18aczt	305	13	.	.	.
cord-023417-by18aczt	306	1	This	this	DT
cord-023417-by18aczt	306	2	method	method	NN
cord-023417-by18aczt	306	3	was	be	VBD
cord-023417-by18aczt	306	4	compared	compare	VBN
cord-023417-by18aczt	306	5	to	to	IN
cord-023417-by18aczt	306	6	the	the	DT
cord-023417-by18aczt	306	7	current	current	JJ
cord-023417-by18aczt	306	8	standard	standard	JJ
cord-023417-by18aczt	306	9	51Cr	51cr	CD
cord-023417-by18aczt	306	10	release	release	NN
cord-023417-by18aczt	306	11	assay	assay	NN
cord-023417-by18aczt	306	12	.	.	.
cord-023417-by18aczt	307	1	Cells	cell	NNS
cord-023417-by18aczt	307	2	were	be	VBD
cord-023417-by18aczt	307	3	treated	treat	VBN
cord-023417-by18aczt	307	4	with	with	IN
cord-023417-by18aczt	307	5	BFA	BFA	NNP
cord-023417-by18aczt	307	6	to	to	TO
cord-023417-by18aczt	307	7	accumulate	accumulate	VB
cord-023417-by18aczt	307	8	IFN	IFN	NNP
cord-023417-by18aczt	307	9	-	-	HYPH
cord-023417-by18aczt	307	10	g	g	NNP
cord-023417-by18aczt	307	11	,	,	,
cord-023417-by18aczt	307	12	stained	stain	VBN
cord-023417-by18aczt	307	13	for	for	IN
cord-023417-by18aczt	307	14	surface	surface	NN
cord-023417-by18aczt	307	15	markers	marker	NNS
cord-023417-by18aczt	307	16	,	,	,
cord-023417-by18aczt	307	17	permeabilized	permeabilized	JJ
cord-023417-by18aczt	307	18	and	and	CC
cord-023417-by18aczt	307	19	stained	stain	VBN
cord-023417-by18aczt	307	20	for	for	IN
cord-023417-by18aczt	307	21	intracellular	intracellular	JJ
cord-023417-by18aczt	307	22	IFN	IFN	NNP
cord-023417-by18aczt	307	23	-	-	HYPH
cord-023417-by18aczt	307	24	g	g	NNP
cord-023417-by18aczt	307	25	.	.	.
cord-023417-by18aczt	308	1	Flow	flow	NN
cord-023417-by18aczt	308	2	cytometry	cytometry	NN
cord-023417-by18aczt	308	3	was	be	VBD
cord-023417-by18aczt	308	4	then	then	RB
cord-023417-by18aczt	308	5	performed	perform	VBN
cord-023417-by18aczt	308	6	to	to	TO
cord-023417-by18aczt	308	7	measure	measure	VB
cord-023417-by18aczt	308	8	intracellular	intracellular	JJ
cord-023417-by18aczt	308	9	IFN	IFN	NNP
cord-023417-by18aczt	308	10	-	-	HYPH
cord-023417-by18aczt	308	11	g	g	NN
cord-023417-by18aczt	308	12	production	production	NN
cord-023417-by18aczt	308	13	in	in	IN
cord-023417-by18aczt	308	14	PBMC	PBMC	NNP
cord-023417-by18aczt	308	15	,	,	,
cord-023417-by18aczt	308	16	especially	especially	RB
cord-023417-by18aczt	308	17	in	in	IN
cord-023417-by18aczt	308	18	NK	NK	NNP
cord-023417-by18aczt	308	19	cells	cell	NNS
cord-023417-by18aczt	308	20	.	.	.
cord-023417-by18aczt	309	1	Results	result	NNS
cord-023417-by18aczt	309	2	:	:	:
cord-023417-by18aczt	310	1	We	-PRON-	PRP
cord-023417-by18aczt	310	2	have	have	VBP
cord-023417-by18aczt	310	3	demonstrated	demonstrate	VBN
cord-023417-by18aczt	310	4	that	that	IN
cord-023417-by18aczt	310	5	stimulation	stimulation	NN
cord-023417-by18aczt	310	6	with	with	IN
cord-023417-by18aczt	310	7	IL-2	IL-2	NNP
cord-023417-by18aczt	310	8	and	and	CC
cord-023417-by18aczt	310	9	IL-12	IL-12	NNP
cord-023417-by18aczt	310	10	is	be	VBZ
cord-023417-by18aczt	310	11	effective	effective	JJ
cord-023417-by18aczt	310	12	in	in	IN
cord-023417-by18aczt	310	13	increasing	increase	VBG
cord-023417-by18aczt	310	14	the	the	DT
cord-023417-by18aczt	310	15	number	number	NN
cord-023417-by18aczt	310	16	of	of	IN
cord-023417-by18aczt	310	17	IFN	IFN	NNP
cord-023417-by18aczt	310	18	-	-	HYPH
cord-023417-by18aczt	310	19	gpositive	gpositive	NN
cord-023417-by18aczt	310	20	cells	cell	NNS
cord-023417-by18aczt	310	21	.	.	.
cord-023417-by18aczt	311	1	There	there	EX
cord-023417-by18aczt	311	2	is	be	VBZ
cord-023417-by18aczt	311	3	a	a	DT
cord-023417-by18aczt	311	4	distinct	distinct	JJ
cord-023417-by18aczt	311	5	difference	difference	NN
cord-023417-by18aczt	311	6	between	between	IN
cord-023417-by18aczt	311	7	the	the	DT
cord-023417-by18aczt	311	8	CD3-CD56dim	CD3-CD56dim	NNP
cord-023417-by18aczt	311	9	and	and	CC
cord-023417-by18aczt	311	10	the	the	DT
cord-023417-by18aczt	311	11	CD3-CD56bright	cd3-cd56bright	NN
cord-023417-by18aczt	311	12	subsets	subset	NNS
cord-023417-by18aczt	311	13	,	,	,
cord-023417-by18aczt	311	14	with	with	IN
cord-023417-by18aczt	311	15	a	a	DT
cord-023417-by18aczt	311	16	much	much	RB
cord-023417-by18aczt	311	17	greater	great	JJR
cord-023417-by18aczt	311	18	proportion	proportion	NN
cord-023417-by18aczt	311	19	of	of	IN
cord-023417-by18aczt	311	20	IFN	IFN	NNP
cord-023417-by18aczt	311	21	-	-	HYPH
cord-023417-by18aczt	311	22	g	g	NN
cord-023417-by18aczt	311	23	-	-	HYPH
cord-023417-by18aczt	311	24	positive	positive	JJ
cord-023417-by18aczt	311	25	cells	cell	NNS
cord-023417-by18aczt	311	26	in	in	IN
cord-023417-by18aczt	311	27	the	the	DT
cord-023417-by18aczt	311	28	CD3-CD56bright	cd3-cd56bright	NN
cord-023417-by18aczt	311	29	subset	subset	JJ
cord-023417-by18aczt	311	30	.	.	.
cord-023417-by18aczt	312	1	The	the	DT
cord-023417-by18aczt	312	2	effects	effect	NNS
cord-023417-by18aczt	312	3	of	of	IN
cord-023417-by18aczt	312	4	stimulation	stimulation	NN
cord-023417-by18aczt	312	5	with	with	IN
cord-023417-by18aczt	312	6	IL-2	IL-2	NNP
cord-023417-by18aczt	312	7	and	and	CC
cord-023417-by18aczt	312	8	IL-12	IL-12	NNP
cord-023417-by18aczt	312	9	on	on	IN
cord-023417-by18aczt	312	10	cytotoxicity	cytotoxicity	NN
cord-023417-by18aczt	312	11	will	will	MD
cord-023417-by18aczt	312	12	be	be	VB
cord-023417-by18aczt	312	13	presented	present	VBN
cord-023417-by18aczt	312	14	,	,	,
cord-023417-by18aczt	312	15	as	as	IN
cord-023417-by18aczt	312	16	will	will	MD
cord-023417-by18aczt	312	17	the	the	DT
cord-023417-by18aczt	312	18	relation	relation	NN
cord-023417-by18aczt	312	19	between	between	IN
cord-023417-by18aczt	312	20	IFN	IFN	NNP
cord-023417-by18aczt	312	21	-	-	HYPH
cord-023417-by18aczt	312	22	g	g	NN
cord-023417-by18aczt	312	23	production	production	NN
cord-023417-by18aczt	312	24	and	and	CC
cord-023417-by18aczt	312	25	cytotoxicity	cytotoxicity	NN
cord-023417-by18aczt	312	26	.	.	.
cord-023417-by18aczt	313	1	In	in	IN
cord-023417-by18aczt	313	2	addition	addition	NN
cord-023417-by18aczt	313	3	,	,	,
cord-023417-by18aczt	313	4	we	-PRON-	PRP
cord-023417-by18aczt	313	5	will	will	MD
cord-023417-by18aczt	313	6	present	present	VB
cord-023417-by18aczt	313	7	results	result	NNS
cord-023417-by18aczt	313	8	of	of	IN
cord-023417-by18aczt	313	9	these	these	DT
cord-023417-by18aczt	313	10	assays	assay	NNS
cord-023417-by18aczt	313	11	applied	apply	VBN
cord-023417-by18aczt	313	12	to	to	IN
cord-023417-by18aczt	313	13	porcine	porcine	JJ
cord-023417-by18aczt	313	14	cells	cell	NNS
cord-023417-by18aczt	313	15	.	.	.
cord-023417-by18aczt	314	1	Discussion	discussion	NN
cord-023417-by18aczt	314	2	:	:	:
cord-023417-by18aczt	315	1	In	in	IN
cord-023417-by18aczt	315	2	combination	combination	NN
cord-023417-by18aczt	315	3	,	,	,
cord-023417-by18aczt	315	4	these	these	DT
cord-023417-by18aczt	315	5	tests	test	NNS
cord-023417-by18aczt	315	6	will	will	MD
cord-023417-by18aczt	315	7	address	address	VB
cord-023417-by18aczt	315	8	NK	NK	NNP
cord-023417-by18aczt	315	9	cell	cell	NN
cord-023417-by18aczt	315	10	function	function	NN
cord-023417-by18aczt	315	11	by	by	IN
cord-023417-by18aczt	315	12	combining	combine	VBG
cord-023417-by18aczt	315	13	cytotoxicity	cytotoxicity	NN
cord-023417-by18aczt	315	14	with	with	IN
cord-023417-by18aczt	315	15	IFN	IFN	NNP
cord-023417-by18aczt	315	16	-	-	HYPH
cord-023417-by18aczt	315	17	g	g	NN
cord-023417-by18aczt	315	18	production	production	NN
cord-023417-by18aczt	315	19	in	in	IN
cord-023417-by18aczt	315	20	NK	NK	NNP
cord-023417-by18aczt	315	21	cell	cell	NN
cord-023417-by18aczt	315	22	subsets	subset	NNS
cord-023417-by18aczt	315	23	.	.	.
cord-023417-by18aczt	316	1	The	the	DT
cord-023417-by18aczt	316	2	results	result	NNS
cord-023417-by18aczt	316	3	will	will	MD
cord-023417-by18aczt	316	4	demonstrate	demonstrate	VB
cord-023417-by18aczt	316	5	whether	whether	IN
cord-023417-by18aczt	316	6	this	this	DT
cord-023417-by18aczt	316	7	could	could	MD
cord-023417-by18aczt	316	8	serve	serve	VB
cord-023417-by18aczt	316	9	as	as	IN
cord-023417-by18aczt	316	10	a	a	DT
cord-023417-by18aczt	316	11	useful	useful	JJ
cord-023417-by18aczt	316	12	tool	tool	NN
cord-023417-by18aczt	316	13	in	in	IN
cord-023417-by18aczt	316	14	describing	describe	VBG
cord-023417-by18aczt	316	15	NKcell	NKcell	NNP
cord-023417-by18aczt	316	16	function	function	NN
cord-023417-by18aczt	316	17	,	,	,
cord-023417-by18aczt	316	18	which	which	WDT
cord-023417-by18aczt	316	19	could	could	MD
cord-023417-by18aczt	316	20	be	be	VB
cord-023417-by18aczt	316	21	of	of	IN
cord-023417-by18aczt	316	22	value	value	NN
cord-023417-by18aczt	316	23	in	in	IN
cord-023417-by18aczt	316	24	clinical	clinical	JJ
cord-023417-by18aczt	316	25	and	and	CC
cord-023417-by18aczt	316	26	experimental	experimental	JJ
cord-023417-by18aczt	316	27	settings	setting	NNS
cord-023417-by18aczt	316	28	.	.	.
cord-023417-by18aczt	317	1	Culture	culture	NN
cord-023417-by18aczt	317	2	of	of	IN
cord-023417-by18aczt	317	3	Regulatory	Regulatory	NNP
cord-023417-by18aczt	317	4	T	T	NNP
cord-023417-by18aczt	317	5	-	-	HYPH
cord-023417-by18aczt	317	6	Cell	cell	NN
cord-023417-by18aczt	317	7	Lines	line	NNS
cord-023417-by18aczt	317	8	from	from	IN
cord-023417-by18aczt	317	9	Bronchial	Bronchial	NNP
cord-023417-by18aczt	317	10	Mucosa	Mucosa	NNP
cord-023417-by18aczt	317	11	T	T	NNP
cord-023417-by18aczt	317	12	lymphocytes	lymphocyte	NNS
cord-023417-by18aczt	317	13	play	play	VBP
cord-023417-by18aczt	317	14	a	a	DT
cord-023417-by18aczt	317	15	major	major	JJ
cord-023417-by18aczt	317	16	role	role	NN
cord-023417-by18aczt	317	17	in	in	IN
cord-023417-by18aczt	317	18	many	many	JJ
cord-023417-by18aczt	317	19	immune	immune	JJ
cord-023417-by18aczt	317	20	responses	response	NNS
cord-023417-by18aczt	317	21	.	.	.
cord-023417-by18aczt	318	1	In	in	IN
cord-023417-by18aczt	318	2	the	the	DT
cord-023417-by18aczt	318	3	last	last	JJ
cord-023417-by18aczt	318	4	decade	decade	NN
cord-023417-by18aczt	318	5	,	,	,
cord-023417-by18aczt	318	6	special	special	JJ
cord-023417-by18aczt	318	7	focus	focus	NN
cord-023417-by18aczt	318	8	has	have	VBZ
cord-023417-by18aczt	318	9	been	be	VBN
cord-023417-by18aczt	318	10	on	on	IN
cord-023417-by18aczt	318	11	the	the	DT
cord-023417-by18aczt	318	12	function	function	NN
cord-023417-by18aczt	318	13	of	of	IN
cord-023417-by18aczt	318	14	Th1	th1	NN
cord-023417-by18aczt	318	15	and	and	CC
cord-023417-by18aczt	318	16	Th2	th2	CD
cord-023417-by18aczt	318	17	effector	effector	NN
cord-023417-by18aczt	318	18	cells	cell	NNS
cord-023417-by18aczt	318	19	.	.	.
cord-023417-by18aczt	319	1	Now	now	RB
cord-023417-by18aczt	319	2	the	the	DT
cord-023417-by18aczt	319	3	importance	importance	NN
cord-023417-by18aczt	319	4	of	of	IN
cord-023417-by18aczt	319	5	regulatory	regulatory	JJ
cord-023417-by18aczt	319	6	CD4	CD4	NNP
cord-023417-by18aczt	319	7	þ	þ	NNP
cord-023417-by18aczt	319	8	CD25	CD25	NNP
cord-023417-by18aczt	319	9	þ	þ	NNP
cord-023417-by18aczt	319	10	T	t	NN
cord-023417-by18aczt	319	11	cells	cell	NNS
cord-023417-by18aczt	319	12	in	in	IN
cord-023417-by18aczt	319	13	maintenance	maintenance	NN
cord-023417-by18aczt	319	14	of	of	IN
cord-023417-by18aczt	319	15	the	the	DT
cord-023417-by18aczt	319	16	immunological	immunological	JJ
cord-023417-by18aczt	319	17	homeostasis	homeostasis	NN
cord-023417-by18aczt	319	18	emerges	emerge	VBZ
cord-023417-by18aczt	319	19	.	.	.
cord-023417-by18aczt	320	1	Sarcoidosis	sarcoidosis	NN
cord-023417-by18aczt	320	2	is	be	VBZ
cord-023417-by18aczt	320	3	a	a	DT
cord-023417-by18aczt	320	4	multisystem	multisystem	JJ
cord-023417-by18aczt	320	5	granulomatous	granulomatous	JJ
cord-023417-by18aczt	320	6	disorder	disorder	NN
cord-023417-by18aczt	320	7	often	often	RB
cord-023417-by18aczt	320	8	affecting	affect	VBG
cord-023417-by18aczt	320	9	the	the	DT
cord-023417-by18aczt	320	10	lungs	lung	NNS
cord-023417-by18aczt	320	11	.	.	.
cord-023417-by18aczt	321	1	The	the	DT
cord-023417-by18aczt	321	2	typical	typical	JJ
cord-023417-by18aczt	321	3	sarcoid	sarcoid	NN
cord-023417-by18aczt	321	4	granulomas	granuloma	NNS
cord-023417-by18aczt	321	5	consists	consist	VBZ
cord-023417-by18aczt	321	6	of	of	IN
cord-023417-by18aczt	321	7	epitheloid	epitheloid	NNP
cord-023417-by18aczt	321	8	cells	cell	NNS
cord-023417-by18aczt	321	9	,	,	,
cord-023417-by18aczt	321	10	macrophages	macrophage	NNS
cord-023417-by18aczt	321	11	and	and	CC
cord-023417-by18aczt	321	12	lymphocytes	lymphocyte	NNS
cord-023417-by18aczt	321	13	,	,	,
cord-023417-by18aczt	321	14	mainly	mainly	RB
cord-023417-by18aczt	321	15	CD4	CD4	NNP
cord-023417-by18aczt	321	16	þ	þ	NNP
cord-023417-by18aczt	321	17	T	T	NNP
cord-023417-by18aczt	321	18	cells	cell	NNS
cord-023417-by18aczt	321	19	of	of	IN
cord-023417-by18aczt	321	20	Th1	th1	CD
cord-023417-by18aczt	321	21	phenotype	phenotype	NN
cord-023417-by18aczt	321	22	.	.	.
cord-023417-by18aczt	322	1	We	-PRON-	PRP
cord-023417-by18aczt	322	2	have	have	VBP
cord-023417-by18aczt	322	3	cultured	culture	VBN
cord-023417-by18aczt	322	4	T	t	NN
cord-023417-by18aczt	322	5	cells	cell	NNS
cord-023417-by18aczt	322	6	from	from	IN
cord-023417-by18aczt	322	7	bronchial	bronchial	JJ
cord-023417-by18aczt	322	8	biopsies	biopsy	NNS
cord-023417-by18aczt	322	9	of	of	IN
cord-023417-by18aczt	322	10	patients	patient	NNS
cord-023417-by18aczt	322	11	with	with	IN
cord-023417-by18aczt	322	12	sarcoidosis	sarcoidosi	NNS
cord-023417-by18aczt	322	13	as	as	RB
cord-023417-by18aczt	322	14	well	well	RB
cord-023417-by18aczt	322	15	as	as	IN
cord-023417-by18aczt	322	16	from	from	IN
cord-023417-by18aczt	322	17	controls	control	NNS
cord-023417-by18aczt	322	18	in	in	IN
cord-023417-by18aczt	322	19	high	high	JJ
cord-023417-by18aczt	322	20	levels	level	NNS
cord-023417-by18aczt	322	21	of	of	IN
cord-023417-by18aczt	322	22	interleukin	interleukin	NN
cord-023417-by18aczt	322	23	2	2	CD
cord-023417-by18aczt	322	24	(	(	-LRB-
cord-023417-by18aczt	322	25	IL-2	IL-2	NNP
cord-023417-by18aczt	322	26	)	)	-RRB-
cord-023417-by18aczt	322	27	and	and	CC
cord-023417-by18aczt	322	28	IL-4	IL-4	NNP
cord-023417-by18aczt	322	29	and	and	CC
cord-023417-by18aczt	322	30	demonstrate	demonstrate	VB
cord-023417-by18aczt	322	31	spontaneously	spontaneously	RB
cord-023417-by18aczt	322	32	arising	arise	VBG
cord-023417-by18aczt	322	33	CD4	CD4	NNP
cord-023417-by18aczt	322	34	þ	þ	NNP
cord-023417-by18aczt	322	35	CD25	CD25	NNP
cord-023417-by18aczt	322	36	þ	þ	NNP
cord-023417-by18aczt	322	37	populations	population	NNS
cord-023417-by18aczt	322	38	and	and	CC
cord-023417-by18aczt	322	39	high	high	JJ
cord-023417-by18aczt	322	40	concentrations	concentration	NNS
cord-023417-by18aczt	322	41	of	of	IN
cord-023417-by18aczt	322	42	IL-10	IL-10	NNP
cord-023417-by18aczt	322	43	in	in	IN
cord-023417-by18aczt	322	44	these	these	DT
cord-023417-by18aczt	322	45	cultures	culture	NNS
cord-023417-by18aczt	322	46	.	.	.
cord-023417-by18aczt	323	1	The	the	DT
cord-023417-by18aczt	323	2	main	main	JJ
cord-023417-by18aczt	323	3	difference	difference	NN
cord-023417-by18aczt	323	4	between	between	IN
cord-023417-by18aczt	323	5	cultures	culture	NNS
cord-023417-by18aczt	323	6	of	of	IN
cord-023417-by18aczt	323	7	sarcoid	sarcoid	NNP
cord-023417-by18aczt	323	8	origin	origin	NN
cord-023417-by18aczt	323	9	compared	compare	VBN
cord-023417-by18aczt	323	10	to	to	IN
cord-023417-by18aczt	323	11	controls	control	NNS
cord-023417-by18aczt	323	12	is	be	VBZ
cord-023417-by18aczt	323	13	a	a	DT
cord-023417-by18aczt	323	14	very	very	RB
cord-023417-by18aczt	323	15	much	much	RB
cord-023417-by18aczt	323	16	higher	high	JJR
cord-023417-by18aczt	323	17	concentration	concentration	NN
cord-023417-by18aczt	323	18	of	of	IN
cord-023417-by18aczt	323	19	the	the	DT
cord-023417-by18aczt	323	20	inflammatory	inflammatory	JJ
cord-023417-by18aczt	323	21	cytokines	cytokine	NNS
cord-023417-by18aczt	323	22	IL-6	IL-6	NNP
cord-023417-by18aczt	323	23	and	and	CC
cord-023417-by18aczt	323	24	TNF	TNF	NNP
cord-023417-by18aczt	323	25	-	-	,
cord-023417-by18aczt	323	26	a	a	NN
cord-023417-by18aczt	323	27	in	in	IN
cord-023417-by18aczt	323	28	cultures	culture	NNS
cord-023417-by18aczt	323	29	of	of	IN
cord-023417-by18aczt	323	30	sarcoid	sarcoid	NNP
cord-023417-by18aczt	323	31	origin	origin	NN
cord-023417-by18aczt	323	32	.	.	.
cord-023417-by18aczt	324	1	The	the	DT
cord-023417-by18aczt	324	2	Effects	effect	NNS
cord-023417-by18aczt	324	3	of	of	IN
cord-023417-by18aczt	324	4	Hyperbaric	Hyperbaric	NNP
cord-023417-by18aczt	324	5	Exposure	Exposure	NNP
cord-023417-by18aczt	324	6	on	on	IN
cord-023417-by18aczt	324	7	Human	Human	NNP
cord-023417-by18aczt	324	8	Peripheral	Peripheral	NNP
cord-023417-by18aczt	324	9	Blood	Blood	NNP
cord-023417-by18aczt	324	10	Mononuclear	Mononuclear	NNP
cord-023417-by18aczt	324	11	Cells	Cells	NNPS
cord-023417-by18aczt	324	12	,	,	,
cord-023417-by18aczt	324	13	with	with	IN
cord-023417-by18aczt	324	14	Special	Special	NNP
cord-023417-by18aczt	324	15	Emphasis	Emphasis	NNP
cord-023417-by18aczt	324	16	on	on	IN
cord-023417-by18aczt	324	17	Natural	Natural	NNP
cord-023417-by18aczt	324	18	Killer	Killer	NNP
cord-023417-by18aczt	324	19	Cell	Cell	NNP
cord-023417-by18aczt	324	20	Cytotoxicity	Cytotoxicity	NNP
cord-023417-by18aczt	324	21	and	and	CC
cord-023417-by18aczt	324	22	Subsets	Subsets	NNPS
cord-023417-by18aczt	324	23	Materials	material	NNS
cord-023417-by18aczt	324	24	and	and	CC
cord-023417-by18aczt	324	25	methods	method	NNS
cord-023417-by18aczt	324	26	:	:	:
cord-023417-by18aczt	325	1	As	as	IN
cord-023417-by18aczt	325	2	an	an	DT
cord-023417-by18aczt	325	3	experimental	experimental	JJ
cord-023417-by18aczt	325	4	physiological	physiological	JJ
cord-023417-by18aczt	325	5	stress	stress	NN
cord-023417-by18aczt	325	6	model	model	NN
cord-023417-by18aczt	325	7	,	,	,
cord-023417-by18aczt	325	8	we	-PRON-	PRP
cord-023417-by18aczt	325	9	examined	examine	VBD
cord-023417-by18aczt	325	10	the	the	DT
cord-023417-by18aczt	325	11	effects	effect	NNS
cord-023417-by18aczt	325	12	of	of	IN
cord-023417-by18aczt	325	13	hyperbaric	hyperbaric	NN
cord-023417-by18aczt	325	14	exposure	exposure	NN
cord-023417-by18aczt	325	15	on	on	IN
cord-023417-by18aczt	325	16	peripheral	peripheral	JJ
cord-023417-by18aczt	325	17	blood	blood	NN
cord-023417-by18aczt	325	18	mononuclear	mononuclear	NN
cord-023417-by18aczt	325	19	cells	cell	NNS
cord-023417-by18aczt	325	20	(	(	-LRB-
cord-023417-by18aczt	325	21	PBMCs	pbmc	NNS
cord-023417-by18aczt	325	22	)	)	-RRB-
cord-023417-by18aczt	325	23	obtained	obtain	VBN
cord-023417-by18aczt	325	24	from	from	IN
cord-023417-by18aczt	325	25	venous	venous	JJ
cord-023417-by18aczt	325	26	blood	blood	NN
cord-023417-by18aczt	325	27	drawn	draw	VBN
cord-023417-by18aczt	325	28	from	from	IN
cord-023417-by18aczt	325	29	eight	eight	CD
cord-023417-by18aczt	325	30	divers	diver	NNS
cord-023417-by18aczt	325	31	during	during	IN
cord-023417-by18aczt	325	32	a	a	DT
cord-023417-by18aczt	325	33	simulated	simulate	VBN
cord-023417-by18aczt	325	34	heliox	heliox	NN
cord-023417-by18aczt	325	35	saturation	saturation	NN
cord-023417-by18aczt	325	36	dive	dive	NN
cord-023417-by18aczt	325	37	.	.	.
cord-023417-by18aczt	326	1	Eight	eight	CD
cord-023417-by18aczt	326	2	persons	person	NNS
cord-023417-by18aczt	326	3	working	work	VBG
cord-023417-by18aczt	326	4	in	in	IN
cord-023417-by18aczt	326	5	normobar	normobar	NNP
cord-023417-by18aczt	326	6	atmosphere	atmosphere	NN
cord-023417-by18aczt	326	7	outside	outside	IN
cord-023417-by18aczt	326	8	the	the	DT
cord-023417-by18aczt	326	9	pressurized	pressurize	VBN
cord-023417-by18aczt	326	10	chamber	chamber	NN
cord-023417-by18aczt	326	11	served	serve	VBD
cord-023417-by18aczt	326	12	as	as	IN
cord-023417-by18aczt	326	13	control	control	NN
cord-023417-by18aczt	326	14	donors	donor	NNS
cord-023417-by18aczt	326	15	.	.	.
cord-023417-by18aczt	327	1	The	the	DT
cord-023417-by18aczt	327	2	spontaneous	spontaneous	JJ
cord-023417-by18aczt	327	3	cytotoxicity	cytotoxicity	NN
cord-023417-by18aczt	327	4	of	of	IN
cord-023417-by18aczt	327	5	the	the	DT
cord-023417-by18aczt	327	6	PBMCs	pbmc	NNS
cord-023417-by18aczt	327	7	was	be	VBD
cord-023417-by18aczt	327	8	estimated	estimate	VBN
cord-023417-by18aczt	327	9	in	in	IN
cord-023417-by18aczt	327	10	a	a	DT
cord-023417-by18aczt	327	11	4	4	CD
cord-023417-by18aczt	327	12	h	h	NN
cord-023417-by18aczt	327	13	51Cr	51cr	CD
cord-023417-by18aczt	327	14	-	-	HYPH
cord-023417-by18aczt	327	15	release	release	NN
cord-023417-by18aczt	327	16	assay	assay	NN
cord-023417-by18aczt	327	17	using	use	VBG
cord-023417-by18aczt	327	18	k562	k562	NNP
cord-023417-by18aczt	327	19	as	as	IN
cord-023417-by18aczt	327	20	NK	nk	NN
cord-023417-by18aczt	327	21	-	-	HYPH
cord-023417-by18aczt	327	22	sensitive	sensitive	JJ
cord-023417-by18aczt	327	23	target	target	NN
cord-023417-by18aczt	327	24	cells	cell	NNS
cord-023417-by18aczt	327	25	.	.	.
cord-023417-by18aczt	328	1	The	the	DT
cord-023417-by18aczt	328	2	PBMCs	pbmc	NNS
cord-023417-by18aczt	328	3	were	be	VBD
cord-023417-by18aczt	328	4	characterized	characterize	VBN
cord-023417-by18aczt	328	5	,	,	,
cord-023417-by18aczt	328	6	using	use	VBG
cord-023417-by18aczt	328	7	4-colour	4-colour	CD
cord-023417-by18aczt	328	8	flow	flow	NN
cord-023417-by18aczt	328	9	cytometry	cytometry	NN
cord-023417-by18aczt	328	10	,	,	,
cord-023417-by18aczt	328	11	with	with	IN
cord-023417-by18aczt	328	12	special	special	JJ
cord-023417-by18aczt	328	13	emphasis	emphasis	NN
cord-023417-by18aczt	328	14	on	on	IN
cord-023417-by18aczt	328	15	the	the	DT
cord-023417-by18aczt	328	16	NK	nk	NN
cord-023417-by18aczt	328	17	-	-	HYPH
cord-023417-by18aczt	328	18	cell	cell	NN
cord-023417-by18aczt	328	19	subsets	subset	NNS
cord-023417-by18aczt	328	20	.	.	.
cord-023417-by18aczt	329	1	The	the	DT
cord-023417-by18aczt	329	2	data	datum	NNS
cord-023417-by18aczt	329	3	were	be	VBD
cord-023417-by18aczt	329	4	statistically	statistically	RB
cord-023417-by18aczt	329	5	analysed	analyse	VBN
cord-023417-by18aczt	329	6	using	use	VBG
cord-023417-by18aczt	329	7	a	a	DT
cord-023417-by18aczt	329	8	multivariate	multivariate	JJ
cord-023417-by18aczt	329	9	regression	regression	NN
cord-023417-by18aczt	329	10	model	model	NN
cord-023417-by18aczt	329	11	(	(	-LRB-
cord-023417-by18aczt	329	12	Stata	Stata	NNP
cord-023417-by18aczt	329	13	8.2	8.2	CD
cord-023417-by18aczt	329	14	)	)	-RRB-
cord-023417-by18aczt	329	15	.	.	.
cord-023417-by18aczt	330	1	P	p	NN
cord-023417-by18aczt	330	2	values	value	NNS
cord-023417-by18aczt	330	3	<	<	XX
cord-023417-by18aczt	330	4	0.05	0.05	CD
cord-023417-by18aczt	330	5	was	be	VBD
cord-023417-by18aczt	330	6	considered	consider	VBN
cord-023417-by18aczt	330	7	statistically	statistically	RB
cord-023417-by18aczt	330	8	significant	significant	JJ
cord-023417-by18aczt	330	9	.	.	.
cord-023417-by18aczt	331	1	Results	result	NNS
cord-023417-by18aczt	331	2	:	:	:
cord-023417-by18aczt	332	1	The	the	DT
cord-023417-by18aczt	332	2	estimated	estimate	VBN
cord-023417-by18aczt	332	3	cytotoxicity	cytotoxicity	NN
cord-023417-by18aczt	332	4	increased	increase	VBD
cord-023417-by18aczt	332	5	significantly	significantly	RB
cord-023417-by18aczt	332	6	in	in	IN
cord-023417-by18aczt	332	7	both	both	CC
cord-023417-by18aczt	332	8	the	the	DT
cord-023417-by18aczt	332	9	group	group	NN
cord-023417-by18aczt	332	10	of	of	IN
cord-023417-by18aczt	332	11	divers	diver	NNS
cord-023417-by18aczt	332	12	and	and	CC
cord-023417-by18aczt	332	13	control	control	VB
cord-023417-by18aczt	332	14	donors	donor	NNS
cord-023417-by18aczt	332	15	during	during	IN
cord-023417-by18aczt	332	16	the	the	DT
cord-023417-by18aczt	332	17	dive	dive	NN
cord-023417-by18aczt	332	18	(	(	-LRB-
cord-023417-by18aczt	332	19	pdivers	pdivers	NNP
cord-023417-by18aczt	332	20	<	<	XX
cord-023417-by18aczt	332	21	0.01	0.01	CD
cord-023417-by18aczt	332	22	and	and	CC
cord-023417-by18aczt	332	23	pcontrols	pcontrols	NNP
cord-023417-by18aczt	332	24	<	<	XX
cord-023417-by18aczt	332	25	0.01	0.01	CD
cord-023417-by18aczt	332	26	)	)	-RRB-
cord-023417-by18aczt	332	27	.	.	.
cord-023417-by18aczt	333	1	Although	although	IN
cord-023417-by18aczt	333	2	the	the	DT
cord-023417-by18aczt	333	3	cytotoxicity	cytotoxicity	NN
cord-023417-by18aczt	333	4	increased	increase	VBD
cord-023417-by18aczt	333	5	relatively	relatively	RB
cord-023417-by18aczt	333	6	more	more	RBR
cord-023417-by18aczt	333	7	(	(	-LRB-
cord-023417-by18aczt	333	8	P	p	NN
cord-023417-by18aczt	333	9	<	<	XX
cord-023417-by18aczt	333	10	0.01	0.01	CD
cord-023417-by18aczt	333	11	)	)	-RRB-
cord-023417-by18aczt	333	12	in	in	IN
cord-023417-by18aczt	333	13	the	the	DT
cord-023417-by18aczt	333	14	group	group	NN
cord-023417-by18aczt	333	15	of	of	IN
cord-023417-by18aczt	333	16	divers	diver	NNS
cord-023417-by18aczt	333	17	compared	compare	VBN
cord-023417-by18aczt	333	18	to	to	IN
cord-023417-by18aczt	333	19	the	the	DT
cord-023417-by18aczt	333	20	group	group	NN
cord-023417-by18aczt	333	21	of	of	IN
cord-023417-by18aczt	333	22	control	control	NN
cord-023417-by18aczt	333	23	donors	donor	NNS
cord-023417-by18aczt	333	24	between	between	IN
cord-023417-by18aczt	333	25	day	day	NN
cord-023417-by18aczt	333	26	1	1	CD
cord-023417-by18aczt	333	27	and	and	CC
cord-023417-by18aczt	333	28	2	2	CD
cord-023417-by18aczt	333	29	.	.	.
cord-023417-by18aczt	334	1	Discussion	discussion	NN
cord-023417-by18aczt	334	2	:	:	:
cord-023417-by18aczt	335	1	The	the	DT
cord-023417-by18aczt	335	2	increased	increase	VBN
cord-023417-by18aczt	335	3	cytotoxicity	cytotoxicity	NN
cord-023417-by18aczt	335	4	of	of	IN
cord-023417-by18aczt	335	5	PBMC	PBMC	NNP
cord-023417-by18aczt	335	6	estimated	estimate	VBN
cord-023417-by18aczt	335	7	in	in	IN
cord-023417-by18aczt	335	8	the	the	DT
cord-023417-by18aczt	335	9	group	group	NN
cord-023417-by18aczt	335	10	of	of	IN
cord-023417-by18aczt	335	11	divers	diver	NNS
cord-023417-by18aczt	335	12	indicate	indicate	VBP
cord-023417-by18aczt	335	13	that	that	IN
cord-023417-by18aczt	335	14	parts	part	NNS
cord-023417-by18aczt	335	15	of	of	IN
cord-023417-by18aczt	335	16	the	the	DT
cord-023417-by18aczt	335	17	cellular	cellular	JJ
cord-023417-by18aczt	335	18	immune	immune	JJ
cord-023417-by18aczt	335	19	system	system	NN
cord-023417-by18aczt	335	20	are	be	VBP
cord-023417-by18aczt	335	21	affected	affect	VBN
cord-023417-by18aczt	335	22	during	during	IN
cord-023417-by18aczt	335	23	the	the	DT
cord-023417-by18aczt	335	24	extreme	extreme	JJ
cord-023417-by18aczt	335	25	physiological	physiological	JJ
cord-023417-by18aczt	335	26	conditions	condition	NNS
cord-023417-by18aczt	335	27	induced	induce	VBN
cord-023417-by18aczt	335	28	during	during	IN
cord-023417-by18aczt	335	29	the	the	DT
cord-023417-by18aczt	335	30	initial	initial	JJ
cord-023417-by18aczt	335	31	phase	phase	NN
cord-023417-by18aczt	335	32	of	of	IN
cord-023417-by18aczt	335	33	the	the	DT
cord-023417-by18aczt	335	34	presented	present	VBN
cord-023417-by18aczt	335	35	experimental	experimental	JJ
cord-023417-by18aczt	335	36	hyperbaric	hyperbaric	NN
cord-023417-by18aczt	335	37	setup	setup	NN
cord-023417-by18aczt	335	38	.	.	.
cord-023417-by18aczt	336	1	The	the	DT
cord-023417-by18aczt	336	2	increase	increase	NN
cord-023417-by18aczt	336	3	in	in	IN
cord-023417-by18aczt	336	4	cytotoxicity	cytotoxicity	NN
cord-023417-by18aczt	336	5	observed	observe	VBN
cord-023417-by18aczt	336	6	in	in	IN
cord-023417-by18aczt	336	7	the	the	DT
cord-023417-by18aczt	336	8	group	group	NN
cord-023417-by18aczt	336	9	of	of	IN
cord-023417-by18aczt	336	10	control	control	NN
cord-023417-by18aczt	336	11	donors	donor	NNS
cord-023417-by18aczt	336	12	could	could	MD
cord-023417-by18aczt	336	13	hypothetically	hypothetically	RB
cord-023417-by18aczt	336	14	reflect	reflect	VB
cord-023417-by18aczt	336	15	the	the	DT
cord-023417-by18aczt	336	16	stress	stress	NN
cord-023417-by18aczt	336	17	level	level	NN
cord-023417-by18aczt	336	18	in	in	IN
cord-023417-by18aczt	336	19	persons	person	NNS
cord-023417-by18aczt	336	20	working	work	VBG
cord-023417-by18aczt	336	21	outside	outside	IN
cord-023417-by18aczt	336	22	the	the	DT
cord-023417-by18aczt	336	23	pressurized	pressurize	VBN
cord-023417-by18aczt	336	24	chamber	chamber	NN
cord-023417-by18aczt	336	25	during	during	IN
cord-023417-by18aczt	336	26	the	the	DT
cord-023417-by18aczt	336	27	dive	dive	NN
cord-023417-by18aczt	336	28	.	.	.
cord-023417-by18aczt	337	1	The	the	DT
cord-023417-by18aczt	337	2	interaction	interaction	NN
cord-023417-by18aczt	337	3	with	with	IN
cord-023417-by18aczt	337	4	adhesion	adhesion	NN
cord-023417-by18aczt	337	5	molecules	molecule	NNS
cord-023417-by18aczt	337	6	expressed	express	VBN
cord-023417-by18aczt	337	7	by	by	IN
cord-023417-by18aczt	337	8	vascular	vascular	JJ
cord-023417-by18aczt	337	9	endothelium	endothelium	NN
cord-023417-by18aczt	337	10	is	be	VBZ
cord-023417-by18aczt	337	11	the	the	DT
cord-023417-by18aczt	337	12	first	first	JJ
cord-023417-by18aczt	337	13	step	step	NN
cord-023417-by18aczt	337	14	in	in	IN
cord-023417-by18aczt	337	15	lymphocyte	lymphocyte	NN
cord-023417-by18aczt	337	16	infiltration	infiltration	NN
cord-023417-by18aczt	337	17	into	into	IN
cord-023417-by18aczt	337	18	tissues	tissue	NNS
cord-023417-by18aczt	337	19	.	.	.
cord-023417-by18aczt	338	1	At	at	IN
cord-023417-by18aczt	338	2	both	both	CC
cord-023417-by18aczt	338	3	cutaneous	cutaneous	JJ
cord-023417-by18aczt	338	4	and	and	CC
cord-023417-by18aczt	338	5	mucosal	mucosal	JJ
cord-023417-by18aczt	338	6	sites	site	NNS
cord-023417-by18aczt	338	7	interleukin-10	interleukin-10	NN
cord-023417-by18aczt	338	8	(	(	-LRB-
cord-023417-by18aczt	338	9	IL-10	IL-10	NNP
cord-023417-by18aczt	338	10	)	)	-RRB-
cord-023417-by18aczt	338	11	,	,	,
cord-023417-by18aczt	338	12	IL-12	IL-12	NNP
cord-023417-by18aczt	338	13	and	and	CC
cord-023417-by18aczt	338	14	transforming	transform	VBG
cord-023417-by18aczt	338	15	growth	growth	NN
cord-023417-by18aczt	338	16	factor	factor	NN
cord-023417-by18aczt	338	17	(	(	-LRB-
cord-023417-by18aczt	338	18	TGF)-b	TGF)-b	NNS
cord-023417-by18aczt	338	19	are	be	VBP
cord-023417-by18aczt	338	20	important	important	JJ
cord-023417-by18aczt	338	21	regulators	regulator	NNS
cord-023417-by18aczt	338	22	of	of	IN
cord-023417-by18aczt	338	23	chronic	chronic	JJ
cord-023417-by18aczt	338	24	inflammatory	inflammatory	JJ
cord-023417-by18aczt	338	25	disease	disease	NN
cord-023417-by18aczt	338	26	,	,	,
cord-023417-by18aczt	338	27	where	where	WRB
cord-023417-by18aczt	338	28	cutaneous	cutaneous	JJ
cord-023417-by18aczt	338	29	lymphocyteassociated	lymphocyteassociated	JJ
cord-023417-by18aczt	338	30	antigen	antigen	NN
cord-023417-by18aczt	338	31	(	(	-LRB-
cord-023417-by18aczt	338	32	CLA	CLA	NNP
cord-023417-by18aczt	338	33	)	)	-RRB-
cord-023417-by18aczt	338	34	and	and	CC
cord-023417-by18aczt	338	35	aE	ae	NN
cord-023417-by18aczt	338	36	integrin	integrin	NNP
cord-023417-by18aczt	338	37	(	(	-LRB-
cord-023417-by18aczt	338	38	CD103	CD103	NNP
cord-023417-by18aczt	338	39	)	)	-RRB-
cord-023417-by18aczt	338	40	may	may	MD
cord-023417-by18aczt	338	41	be	be	VB
cord-023417-by18aczt	338	42	expressed	express	VBN
cord-023417-by18aczt	338	43	.	.	.
cord-023417-by18aczt	339	1	Unlike	unlike	IN
cord-023417-by18aczt	339	2	CLA	CLA	NNP
cord-023417-by18aczt	339	3	,	,	,
cord-023417-by18aczt	339	4	CD103	CD103	NNP
cord-023417-by18aczt	339	5	is	be	VBZ
cord-023417-by18aczt	339	6	not	not	RB
cord-023417-by18aczt	339	7	believed	believe	VBN
cord-023417-by18aczt	339	8	to	to	TO
cord-023417-by18aczt	339	9	play	play	VB
cord-023417-by18aczt	339	10	a	a	DT
cord-023417-by18aczt	339	11	role	role	NN
cord-023417-by18aczt	339	12	in	in	IN
cord-023417-by18aczt	339	13	tissue	tissue	NN
cord-023417-by18aczt	339	14	-	-	HYPH
cord-023417-by18aczt	339	15	specific	specific	JJ
cord-023417-by18aczt	339	16	homing	homing	NN
cord-023417-by18aczt	339	17	but	but	CC
cord-023417-by18aczt	339	18	may	may	MD
cord-023417-by18aczt	339	19	help	help	VB
cord-023417-by18aczt	339	20	to	to	TO
cord-023417-by18aczt	339	21	retain	retain	VB
cord-023417-by18aczt	339	22	T	t	NN
cord-023417-by18aczt	339	23	cells	cell	NNS
cord-023417-by18aczt	339	24	within	within	IN
cord-023417-by18aczt	339	25	epithelial	epithelial	JJ
cord-023417-by18aczt	339	26	layers	layer	NNS
cord-023417-by18aczt	339	27	.	.	.
cord-023417-by18aczt	340	1	We	-PRON-	PRP
cord-023417-by18aczt	340	2	have	have	VBP
cord-023417-by18aczt	340	3	previously	previously	RB
cord-023417-by18aczt	340	4	shown	show	VBN
cord-023417-by18aczt	340	5	that	that	IN
cord-023417-by18aczt	340	6	IL-12	IL-12	NNP
cord-023417-by18aczt	340	7	alone	alone	RB
cord-023417-by18aczt	340	8	can	can	MD
cord-023417-by18aczt	340	9	together	together	RB
cord-023417-by18aczt	340	10	with	with	IN
cord-023417-by18aczt	340	11	an	an	DT
cord-023417-by18aczt	340	12	unknown	unknown	JJ
cord-023417-by18aczt	340	13	cofactor	cofactor	NN
cord-023417-by18aczt	340	14	increase	increase	NN
cord-023417-by18aczt	340	15	the	the	DT
cord-023417-by18aczt	340	16	expression	expression	NN
cord-023417-by18aczt	340	17	of	of	IN
cord-023417-by18aczt	340	18	CLA	CLA	NNP
cord-023417-by18aczt	340	19	.	.	.
cord-023417-by18aczt	341	1	Stimulation	stimulation	NN
cord-023417-by18aczt	341	2	with	with	IN
cord-023417-by18aczt	341	3	streptococcal	streptococcal	JJ
cord-023417-by18aczt	341	4	pyrogenic	pyrogenic	JJ
cord-023417-by18aczt	341	5	exotoxin	exotoxin	NN
cord-023417-by18aczt	341	6	C	C	NNP
cord-023417-by18aczt	341	7	(	(	-LRB-
cord-023417-by18aczt	341	8	SpeC	spec	NN
cord-023417-by18aczt	341	9	)	)	-RRB-
cord-023417-by18aczt	341	10	increased	increase	VBD
cord-023417-by18aczt	341	11	the	the	DT
cord-023417-by18aczt	341	12	expression	expression	NN
cord-023417-by18aczt	341	13	of	of	IN
cord-023417-by18aczt	341	14	CD103	CD103	NNP
cord-023417-by18aczt	341	15	by	by	IN
cord-023417-by18aczt	341	16	CD8	CD8	NNP
cord-023417-by18aczt	341	17	þ	þ	NNP
cord-023417-by18aczt	341	18	but	but	CC
cord-023417-by18aczt	341	19	not	not	RB
cord-023417-by18aczt	341	20	CD4	CD4	NNP
cord-023417-by18aczt	341	21	þ	þ	NNP
cord-023417-by18aczt	341	22	T	t	NN
cord-023417-by18aczt	341	23	cells	cell	NNS
cord-023417-by18aczt	341	24	.	.	.
cord-023417-by18aczt	342	1	While	while	IN
cord-023417-by18aczt	342	2	IL-12	IL-12	NNP
cord-023417-by18aczt	342	3	increased	increase	VBD
cord-023417-by18aczt	342	4	superantigen	superantigen	NN
cord-023417-by18aczt	342	5	-	-	HYPH
cord-023417-by18aczt	342	6	stimulated	stimulate	VBN
cord-023417-by18aczt	342	7	expression	expression	NN
cord-023417-by18aczt	342	8	of	of	IN
cord-023417-by18aczt	342	9	CLA	CLA	NNP
cord-023417-by18aczt	342	10	,	,	,
cord-023417-by18aczt	342	11	this	this	DT
cord-023417-by18aczt	342	12	cytokine	cytokine	NN
cord-023417-by18aczt	342	13	strongly	strongly	RB
cord-023417-by18aczt	342	14	inhibited	inhibit	VBD
cord-023417-by18aczt	342	15	the	the	DT
cord-023417-by18aczt	342	16	CD103	CD103	NNP
cord-023417-by18aczt	342	17	expres	expres	NNP
cord-023417-by18aczt	342	18	-	-	HYPH
cord-023417-by18aczt	342	19	sion	sion	NNP
cord-023417-by18aczt	342	20	,	,	,
cord-023417-by18aczt	342	21	and	and	CC
cord-023417-by18aczt	342	22	a	a	DT
cord-023417-by18aczt	342	23	combination	combination	NN
cord-023417-by18aczt	342	24	of	of	IN
cord-023417-by18aczt	342	25	IL-12	IL-12	NNP
cord-023417-by18aczt	342	26	and	and	CC
cord-023417-by18aczt	342	27	TGF	TGF	NNP
cord-023417-by18aczt	342	28	-	-	HYPH
cord-023417-by18aczt	342	29	b	b	LS
cord-023417-by18aczt	342	30	completely	completely	RB
cord-023417-by18aczt	342	31	abrogated	abrogate	VBD
cord-023417-by18aczt	342	32	the	the	DT
cord-023417-by18aczt	342	33	induced	induce	VBN
cord-023417-by18aczt	342	34	CD103	cd103	NN
cord-023417-by18aczt	342	35	expression	expression	NN
cord-023417-by18aczt	342	36	.	.	.
cord-023417-by18aczt	343	1	Conversely	conversely	RB
cord-023417-by18aczt	343	2	,	,	,
cord-023417-by18aczt	343	3	IL-10	IL-10	NNP
cord-023417-by18aczt	343	4	suppressed	suppress	VBD
cord-023417-by18aczt	343	5	CLA	CLA	NNP
cord-023417-by18aczt	343	6	but	but	CC
cord-023417-by18aczt	343	7	increased	increase	VBD
cord-023417-by18aczt	343	8	CD103	CD103	NNP
cord-023417-by18aczt	343	9	expression	expression	NN
cord-023417-by18aczt	343	10	.	.	.
cord-023417-by18aczt	344	1	These	these	DT
cord-023417-by18aczt	344	2	findings	finding	NNS
cord-023417-by18aczt	344	3	indicate	indicate	VBP
cord-023417-by18aczt	344	4	that	that	IN
cord-023417-by18aczt	344	5	,	,	,
cord-023417-by18aczt	344	6	in	in	IN
cord-023417-by18aczt	344	7	addition	addition	NN
cord-023417-by18aczt	344	8	to	to	IN
cord-023417-by18aczt	344	9	suppressing	suppress	VBG
cord-023417-by18aczt	344	10	the	the	DT
cord-023417-by18aczt	344	11	development	development	NN
cord-023417-by18aczt	344	12	of	of	IN
cord-023417-by18aczt	344	13	Th1-mediated	Th1-mediated	NNP
cord-023417-by18aczt	344	14	inflammatory	inflammatory	JJ
cord-023417-by18aczt	344	15	responses	response	NNS
cord-023417-by18aczt	344	16	,	,	,
cord-023417-by18aczt	344	17	IL-10	IL-10	NNP
cord-023417-by18aczt	344	18	may	may	MD
cord-023417-by18aczt	344	19	also	also	RB
cord-023417-by18aczt	344	20	inhibit	inhibit	VB
cord-023417-by18aczt	344	21	the	the	DT
cord-023417-by18aczt	344	22	migration	migration	NN
cord-023417-by18aczt	344	23	of	of	IN
cord-023417-by18aczt	344	24	CD8	CD8	NNP
cord-023417-by18aczt	344	25	þ	þ	NNP
cord-023417-by18aczt	344	26	T	T	NNP
cord-023417-by18aczt	344	27	cells	cell	NNS
cord-023417-by18aczt	344	28	into	into	IN
cord-023417-by18aczt	344	29	the	the	DT
cord-023417-by18aczt	344	30	skin	skin	NN
cord-023417-by18aczt	344	31	while	while	IN
cord-023417-by18aczt	344	32	IL-12	IL-12	NNP
cord-023417-by18aczt	344	33	promotes	promote	VBZ
cord-023417-by18aczt	344	34	such	such	JJ
cord-023417-by18aczt	344	35	migration	migration	NN
cord-023417-by18aczt	344	36	.	.	.
cord-023417-by18aczt	345	1	Thus	thus	RB
cord-023417-by18aczt	345	2	,	,	,
cord-023417-by18aczt	345	3	the	the	DT
cord-023417-by18aczt	345	4	expression	expression	NN
cord-023417-by18aczt	345	5	of	of	IN
cord-023417-by18aczt	345	6	CLA	CLA	NNP
cord-023417-by18aczt	345	7	and	and	CC
cord-023417-by18aczt	345	8	CD103	CD103	NNP
cord-023417-by18aczt	345	9	may	may	MD
cord-023417-by18aczt	345	10	be	be	VB
cord-023417-by18aczt	345	11	antagonistically	antagonistically	RB
cord-023417-by18aczt	345	12	regulated	regulate	VBN
cord-023417-by18aczt	345	13	by	by	IN
cord-023417-by18aczt	345	14	IL-10	IL-10	NNP
cord-023417-by18aczt	345	15	and	and	CC
cord-023417-by18aczt	345	16	IL-12	IL-12	NNP
cord-023417-by18aczt	345	17	,	,	,
cord-023417-by18aczt	345	18	and	and	CC
cord-023417-by18aczt	345	19	the	the	DT
cord-023417-by18aczt	345	20	balance	balance	NN
cord-023417-by18aczt	345	21	between	between	IN
cord-023417-by18aczt	345	22	these	these	DT
cord-023417-by18aczt	345	23	cytokines	cytokine	NNS
cord-023417-by18aczt	345	24	could	could	MD
cord-023417-by18aczt	345	25	influence	influence	VB
cord-023417-by18aczt	345	26	the	the	DT
cord-023417-by18aczt	345	27	T	t	NN
cord-023417-by18aczt	345	28	-	-	HYPH
cord-023417-by18aczt	345	29	cell	cell	NN
cord-023417-by18aczt	345	30	migration	migration	NN
cord-023417-by18aczt	345	31	of	of	IN
cord-023417-by18aczt	345	32	inflammatory	inflammatory	JJ
cord-023417-by18aczt	345	33	cells	cell	NNS
cord-023417-by18aczt	345	34	into	into	IN
cord-023417-by18aczt	345	35	epithelial	epithelial	JJ
cord-023417-by18aczt	345	36	tissues	tissue	NNS
cord-023417-by18aczt	345	37	.	.	.
cord-023417-by18aczt	346	1	During	during	IN
cord-023417-by18aczt	346	2	contact	contact	NN
cord-023417-by18aczt	346	3	sensitivity	sensitivity	NN
cord-023417-by18aczt	346	4	reaction	reaction	NN
cord-023417-by18aczt	346	5	,	,	,
cord-023417-by18aczt	346	6	immune	immune	JJ
cord-023417-by18aczt	346	7	cells	cell	NNS
cord-023417-by18aczt	346	8	proliferate	proliferate	VBP
cord-023417-by18aczt	346	9	.	.	.
cord-023417-by18aczt	347	1	In	in	IN
cord-023417-by18aczt	347	2	order	order	NN
cord-023417-by18aczt	347	3	to	to	TO
cord-023417-by18aczt	347	4	study	study	VB
cord-023417-by18aczt	347	5	the	the	DT
cord-023417-by18aczt	347	6	histological	histological	JJ
cord-023417-by18aczt	347	7	picture	picture	NN
cord-023417-by18aczt	347	8	of	of	IN
cord-023417-by18aczt	347	9	these	these	DT
cord-023417-by18aczt	347	10	proliferation	proliferation	NN
cord-023417-by18aczt	347	11	phases	phase	NNS
cord-023417-by18aczt	347	12	,	,	,
cord-023417-by18aczt	347	13	we	-PRON-	PRP
cord-023417-by18aczt	347	14	used	use	VBD
cord-023417-by18aczt	347	15	a	a	DT
cord-023417-by18aczt	347	16	mouse	mouse	NN
cord-023417-by18aczt	347	17	model	model	NN
cord-023417-by18aczt	347	18	of	of	IN
cord-023417-by18aczt	347	19	contact	contact	NN
cord-023417-by18aczt	347	20	sensitivity	sensitivity	NN
cord-023417-by18aczt	347	21	in	in	IN
cord-023417-by18aczt	347	22	the	the	DT
cord-023417-by18aczt	347	23	oral	oral	JJ
cord-023417-by18aczt	347	24	mucosa	mucosa	NN
cord-023417-by18aczt	347	25	and	and	CC
cord-023417-by18aczt	347	26	on	on	IN
cord-023417-by18aczt	347	27	skin	skin	NN
cord-023417-by18aczt	347	28	.	.	.
cord-023417-by18aczt	348	1	We	-PRON-	PRP
cord-023417-by18aczt	348	2	also	also	RB
cord-023417-by18aczt	348	3	used	use	VBD
cord-023417-by18aczt	348	4	bromodeoxyuridin	bromodeoxyuridin	NNP
cord-023417-by18aczt	348	5	(	(	-LRB-
cord-023417-by18aczt	348	6	BrdU	BrdU	NNP
cord-023417-by18aczt	348	7	,	,	,
cord-023417-by18aczt	348	8	an	an	DT
cord-023417-by18aczt	348	9	analogue	analogue	NN
cord-023417-by18aczt	348	10	to	to	TO
cord-023417-by18aczt	348	11	thymidin	thymidin	VB
cord-023417-by18aczt	348	12	)	)	-RRB-
cord-023417-by18aczt	348	13	that	that	WDT
cord-023417-by18aczt	348	14	is	be	VBZ
cord-023417-by18aczt	348	15	incorporated	incorporate	VBN
cord-023417-by18aczt	348	16	into	into	IN
cord-023417-by18aczt	348	17	the	the	DT
cord-023417-by18aczt	348	18	nucleus	nucleus	NN
cord-023417-by18aczt	348	19	during	during	IN
cord-023417-by18aczt	348	20	cell	cell	NN
cord-023417-by18aczt	348	21	replication	replication	NN
cord-023417-by18aczt	348	22	.	.	.
cord-023417-by18aczt	349	1	The	the	DT
cord-023417-by18aczt	349	2	hapten	hapten	NNP
cord-023417-by18aczt	349	3	oxazolone	oxazolone	NN
cord-023417-by18aczt	349	4	(	(	-LRB-
cord-023417-by18aczt	349	5	OXA	OXA	NNP
cord-023417-by18aczt	349	6	)	)	-RRB-
cord-023417-by18aczt	349	7	was	be	VBD
cord-023417-by18aczt	349	8	used	use	VBN
cord-023417-by18aczt	349	9	to	to	TO
cord-023417-by18aczt	349	10	sensitize	sensitize	VB
cord-023417-by18aczt	349	11	and	and	CC
cord-023417-by18aczt	349	12	elicit	elicit	VB
cord-023417-by18aczt	349	13	the	the	DT
cord-023417-by18aczt	349	14	oral	oral	JJ
cord-023417-by18aczt	349	15	mucosa	mucosa	NN
cord-023417-by18aczt	349	16	and/or	and/or	CC
cord-023417-by18aczt	349	17	the	the	DT
cord-023417-by18aczt	349	18	ear	ear	NN
cord-023417-by18aczt	349	19	skin	skin	NN
cord-023417-by18aczt	349	20	.	.	.
cord-023417-by18aczt	350	1	Mice	mouse	NNS
cord-023417-by18aczt	350	2	were	be	VBD
cord-023417-by18aczt	350	3	killed	kill	VBN
cord-023417-by18aczt	350	4	at	at	IN
cord-023417-by18aczt	350	5	various	various	JJ
cord-023417-by18aczt	350	6	times	time	NNS
cord-023417-by18aczt	350	7	after	after	IN
cord-023417-by18aczt	350	8	elicitation	elicitation	NN
cord-023417-by18aczt	350	9	,	,	,
cord-023417-by18aczt	350	10	and	and	CC
cord-023417-by18aczt	350	11	unsensitized	unsensitized	JJ
cord-023417-by18aczt	350	12	animals	animal	NNS
cord-023417-by18aczt	350	13	were	be	VBD
cord-023417-by18aczt	350	14	also	also	RB
cord-023417-by18aczt	350	15	exposed	expose	VBN
cord-023417-by18aczt	350	16	to	to	IN
cord-023417-by18aczt	350	17	the	the	DT
cord-023417-by18aczt	350	18	hapten	hapten	NNP
cord-023417-by18aczt	350	19	as	as	IN
cord-023417-by18aczt	350	20	controls	control	NNS
cord-023417-by18aczt	350	21	.	.	.
cord-023417-by18aczt	351	1	BrdU	BrdU	NNP
cord-023417-by18aczt	351	2	(	(	-LRB-
cord-023417-by18aczt	351	3	25	25	CD
cord-023417-by18aczt	351	4	mg/	mg/	NN
cord-023417-by18aczt	351	5	kg	kg	NNP
cord-023417-by18aczt	351	6	animal	animal	NN
cord-023417-by18aczt	351	7	)	)	-RRB-
cord-023417-by18aczt	351	8	was	be	VBD
cord-023417-by18aczt	351	9	injected	inject	VBN
cord-023417-by18aczt	351	10	i.p	i.p	NNP
cord-023417-by18aczt	351	11	.	.	NNP
cord-023417-by18aczt	351	12	2	2	CD
cord-023417-by18aczt	351	13	h	h	NN
cord-023417-by18aczt	351	14	before	before	IN
cord-023417-by18aczt	351	15	the	the	DT
cord-023417-by18aczt	351	16	kill	kill	NN
cord-023417-by18aczt	351	17	.	.	.
cord-023417-by18aczt	352	1	Specimens	specimen	NNS
cord-023417-by18aczt	352	2	from	from	IN
cord-023417-by18aczt	352	3	the	the	DT
cord-023417-by18aczt	352	4	oral	oral	JJ
cord-023417-by18aczt	352	5	mucosa	mucosa	NN
cord-023417-by18aczt	352	6	,	,	,
cord-023417-by18aczt	352	7	ear	ear	NN
cord-023417-by18aczt	352	8	skin	skin	NN
cord-023417-by18aczt	352	9	and	and	CC
cord-023417-by18aczt	352	10	submandibular	submandibular	JJ
cord-023417-by18aczt	352	11	and	and	CC
cord-023417-by18aczt	352	12	auricular	auricular	JJ
cord-023417-by18aczt	352	13	lymph	lymph	NN
cord-023417-by18aczt	352	14	nodes	node	NNS
cord-023417-by18aczt	352	15	were	be	VBD
cord-023417-by18aczt	352	16	cut	cut	VBN
cord-023417-by18aczt	352	17	and	and	CC
cord-023417-by18aczt	352	18	fixed	fix	VBN
cord-023417-by18aczt	352	19	in	in	IN
cord-023417-by18aczt	352	20	4	4	CD
cord-023417-by18aczt	352	21	%	%	NN
cord-023417-by18aczt	352	22	paraformaldehyde	paraformaldehyde	NNP
cord-023417-by18aczt	352	23	.	.	.
cord-023417-by18aczt	353	1	They	-PRON-	PRP
cord-023417-by18aczt	353	2	were	be	VBD
cord-023417-by18aczt	353	3	then	then	RB
cord-023417-by18aczt	353	4	treated	treat	VBN
cord-023417-by18aczt	353	5	with	with	IN
cord-023417-by18aczt	353	6	acid	acid	NN
cord-023417-by18aczt	353	7	and	and	CC
cord-023417-by18aczt	353	8	biotinylated	biotinylated	JJ
cord-023417-by18aczt	353	9	anti	anti	NNP
cord-023417-by18aczt	353	10	-	-	NNP
cord-023417-by18aczt	353	11	BrdU	BrdU	NNP
cord-023417-by18aczt	353	12	antibody	antibody	NN
cord-023417-by18aczt	353	13	and	and	CC
cord-023417-by18aczt	353	14	developed	develop	VBD
cord-023417-by18aczt	353	15	using	use	VBG
cord-023417-by18aczt	353	16	ABC	ABC	NNP
cord-023417-by18aczt	353	17	-	-	HYPH
cord-023417-by18aczt	353	18	kit	kit	NN
cord-023417-by18aczt	353	19	and	and	CC
cord-023417-by18aczt	353	20	DAB	dab	NN
cord-023417-by18aczt	353	21	.	.	.
cord-023417-by18aczt	354	1	The	the	DT
cord-023417-by18aczt	354	2	analyses	analysis	NNS
cord-023417-by18aczt	354	3	were	be	VBD
cord-023417-by18aczt	354	4	performed	perform	VBN
cord-023417-by18aczt	354	5	using	use	VBG
cord-023417-by18aczt	354	6	a	a	DT
cord-023417-by18aczt	354	7	Leica	Leica	NNP
cord-023417-by18aczt	354	8	light	light	JJ
cord-023417-by18aczt	354	9	microscope	microscope	NN
cord-023417-by18aczt	354	10	and	and	CC
cord-023417-by18aczt	354	11	the	the	DT
cord-023417-by18aczt	354	12	computer	computer	NN
cord-023417-by18aczt	354	13	program	program	NN
cord-023417-by18aczt	354	14	ANALYSIS	analysis	NN
cord-023417-by18aczt	354	15	.	.	.
cord-023417-by18aczt	355	1	In	in	IN
cord-023417-by18aczt	355	2	the	the	DT
cord-023417-by18aczt	355	3	oral	oral	JJ
cord-023417-by18aczt	355	4	mucosa	mucosa	NN
cord-023417-by18aczt	355	5	,	,	,
cord-023417-by18aczt	355	6	the	the	DT
cord-023417-by18aczt	355	7	frequency	frequency	NN
cord-023417-by18aczt	355	8	of	of	IN
cord-023417-by18aczt	355	9	proliferating	proliferate	VBG
cord-023417-by18aczt	355	10	cells	cell	NNS
cord-023417-by18aczt	355	11	were	be	VBD
cord-023417-by18aczt	355	12	increasing	increase	VBG
cord-023417-by18aczt	355	13	during	during	IN
cord-023417-by18aczt	355	14	the	the	DT
cord-023417-by18aczt	355	15	observation	observation	NN
cord-023417-by18aczt	355	16	period	period	NN
cord-023417-by18aczt	355	17	,	,	,
cord-023417-by18aczt	355	18	4	4	CD
cord-023417-by18aczt	355	19	-	-	SYM
cord-023417-by18aczt	355	20	24	24	CD
cord-023417-by18aczt	355	21	h	h	NN
cord-023417-by18aczt	355	22	after	after	IN
cord-023417-by18aczt	355	23	elicitation	elicitation	NN
cord-023417-by18aczt	355	24	,	,	,
cord-023417-by18aczt	355	25	regardless	regardless	RB
cord-023417-by18aczt	355	26	of	of	IN
cord-023417-by18aczt	355	27	site	site	NN
cord-023417-by18aczt	355	28	of	of	IN
cord-023417-by18aczt	355	29	sensitization	sensitization	NN
cord-023417-by18aczt	355	30	.	.	.
cord-023417-by18aczt	356	1	The	the	DT
cord-023417-by18aczt	356	2	proliferating	proliferate	VBG
cord-023417-by18aczt	356	3	cells	cell	NNS
cord-023417-by18aczt	356	4	were	be	VBD
cord-023417-by18aczt	356	5	found	find	VBN
cord-023417-by18aczt	356	6	mainly	mainly	RB
cord-023417-by18aczt	356	7	in	in	IN
cord-023417-by18aczt	356	8	the	the	DT
cord-023417-by18aczt	356	9	basal	basal	NN
cord-023417-by18aczt	356	10	cell	cell	NN
cord-023417-by18aczt	356	11	layer	layer	NN
cord-023417-by18aczt	356	12	of	of	IN
cord-023417-by18aczt	356	13	the	the	DT
cord-023417-by18aczt	356	14	epithelium	epithelium	NN
cord-023417-by18aczt	356	15	.	.	.
cord-023417-by18aczt	357	1	Similar	similar	JJ
cord-023417-by18aczt	357	2	patterns	pattern	NNS
cord-023417-by18aczt	357	3	were	be	VBD
cord-023417-by18aczt	357	4	found	find	VBN
cord-023417-by18aczt	357	5	in	in	IN
cord-023417-by18aczt	357	6	ear	ear	NN
cord-023417-by18aczt	357	7	skin	skin	NN
cord-023417-by18aczt	357	8	.	.	.
cord-023417-by18aczt	358	1	The	the	DT
cord-023417-by18aczt	358	2	regional	regional	JJ
cord-023417-by18aczt	358	3	lymph	lymph	NN
cord-023417-by18aczt	358	4	nodes	node	NNS
cord-023417-by18aczt	358	5	demonstrated	demonstrate	VBD
cord-023417-by18aczt	358	6	a	a	DT
cord-023417-by18aczt	358	7	few	few	JJ
cord-023417-by18aczt	358	8	scattered	scatter	VBN
cord-023417-by18aczt	358	9	proliferating	proliferate	VBG
cord-023417-by18aczt	358	10	cells	cell	NNS
cord-023417-by18aczt	358	11	4	4	CD
cord-023417-by18aczt	358	12	h	h	NN
cord-023417-by18aczt	358	13	after	after	IN
cord-023417-by18aczt	358	14	elicitation	elicitation	NN
cord-023417-by18aczt	358	15	.	.	.
cord-023417-by18aczt	359	1	After	after	IN
cord-023417-by18aczt	359	2	24	24	CD
cord-023417-by18aczt	359	3	h	h	NN
cord-023417-by18aczt	359	4	,	,	,
cord-023417-by18aczt	359	5	these	these	DT
cord-023417-by18aczt	359	6	cells	cell	NNS
cord-023417-by18aczt	359	7	were	be	VBD
cord-023417-by18aczt	359	8	found	find	VBN
cord-023417-by18aczt	359	9	frequently	frequently	RB
cord-023417-by18aczt	359	10	in	in	IN
cord-023417-by18aczt	359	11	the	the	DT
cord-023417-by18aczt	359	12	whole	whole	JJ
cord-023417-by18aczt	359	13	lymph	lymph	NN
cord-023417-by18aczt	359	14	node	node	NN
cord-023417-by18aczt	359	15	.	.	.
cord-023417-by18aczt	360	1	Control	control	NN
cord-023417-by18aczt	360	2	animals	animal	NNS
cord-023417-by18aczt	360	3	exhibited	exhibit	VBD
cord-023417-by18aczt	360	4	considerable	considerable	JJ
cord-023417-by18aczt	360	5	less	less	RBR
cord-023417-by18aczt	360	6	proliferating	proliferate	VBG
cord-023417-by18aczt	360	7	cells	cell	NNS
cord-023417-by18aczt	360	8	at	at	IN
cord-023417-by18aczt	360	9	all	all	DT
cord-023417-by18aczt	360	10	times	time	NNS
cord-023417-by18aczt	360	11	.	.	.
cord-023417-by18aczt	361	1	We	-PRON-	PRP
cord-023417-by18aczt	361	2	conclude	conclude	VBP
cord-023417-by18aczt	361	3	that	that	IN
cord-023417-by18aczt	361	4	most	most	RBS
cord-023417-by18aczt	361	5	proliferating	proliferate	VBG
cord-023417-by18aczt	361	6	cells	cell	NNS
cord-023417-by18aczt	361	7	were	be	VBD
cord-023417-by18aczt	361	8	found	find	VBN
cord-023417-by18aczt	361	9	24	24	CD
cord-023417-by18aczt	361	10	h	h	NN
cord-023417-by18aczt	361	11	after	after	IN
cord-023417-by18aczt	361	12	elicitation	elicitation	NN
cord-023417-by18aczt	361	13	locally	locally	RB
cord-023417-by18aczt	361	14	at	at	IN
cord-023417-by18aczt	361	15	the	the	DT
cord-023417-by18aczt	361	16	hapten	hapten	NN
cord-023417-by18aczt	361	17	-	-	HYPH
cord-023417-by18aczt	361	18	exposed	expose	VBN
cord-023417-by18aczt	361	19	sites	site	NNS
cord-023417-by18aczt	361	20	(	(	-LRB-
cord-023417-by18aczt	361	21	the	the	DT
cord-023417-by18aczt	361	22	oral	oral	JJ
cord-023417-by18aczt	361	23	mucosa	mucosa	NN
cord-023417-by18aczt	361	24	or	or	CC
cord-023417-by18aczt	361	25	the	the	DT
cord-023417-by18aczt	361	26	ear	ear	NN
cord-023417-by18aczt	361	27	skin	skin	NN
cord-023417-by18aczt	361	28	)	)	-RRB-
cord-023417-by18aczt	361	29	as	as	RB
cord-023417-by18aczt	361	30	well	well	RB
cord-023417-by18aczt	361	31	as	as	IN
cord-023417-by18aczt	361	32	in	in	IN
cord-023417-by18aczt	361	33	the	the	DT
cord-023417-by18aczt	361	34	regional	regional	JJ
cord-023417-by18aczt	361	35	lymph	lymph	NN
cord-023417-by18aczt	361	36	nodes	node	NNS
cord-023417-by18aczt	361	37	.	.	.
cord-023417-by18aczt	362	1	The	the	DT
cord-023417-by18aczt	362	2	endogenous	endogenous	JJ
cord-023417-by18aczt	362	3	nucleoside	nucleoside	NN
cord-023417-by18aczt	362	4	adenosine	adenosine	NN
cord-023417-by18aczt	362	5	is	be	VBZ
cord-023417-by18aczt	362	6	released	release	VBN
cord-023417-by18aczt	362	7	in	in	IN
cord-023417-by18aczt	362	8	excess	excess	NN
cord-023417-by18aczt	362	9	during	during	IN
cord-023417-by18aczt	362	10	inflammation	inflammation	NN
cord-023417-by18aczt	362	11	or	or	CC
cord-023417-by18aczt	362	12	other	other	JJ
cord-023417-by18aczt	362	13	metabolic	metabolic	JJ
cord-023417-by18aczt	362	14	stress	stress	NN
cord-023417-by18aczt	362	15	and	and	CC
cord-023417-by18aczt	362	16	is	be	VBZ
cord-023417-by18aczt	362	17	generally	generally	RB
cord-023417-by18aczt	362	18	known	know	VBN
cord-023417-by18aczt	362	19	to	to	TO
cord-023417-by18aczt	362	20	deliver	deliver	VB
cord-023417-by18aczt	362	21	tissue	tissue	NN
cord-023417-by18aczt	362	22	protective	protective	JJ
cord-023417-by18aczt	362	23	anti	anti	JJ
cord-023417-by18aczt	362	24	-	-	JJ
cord-023417-by18aczt	362	25	inflammatory	inflammatory	JJ
cord-023417-by18aczt	362	26	effects	effect	NNS
cord-023417-by18aczt	362	27	.	.	.
cord-023417-by18aczt	363	1	Adenosine	adenosine	NN
cord-023417-by18aczt	363	2	acts	act	VBZ
cord-023417-by18aczt	363	3	via	via	IN
cord-023417-by18aczt	363	4	four	four	CD
cord-023417-by18aczt	363	5	adenosine	adenosine	NN
cord-023417-by18aczt	363	6	receptors	receptor	NNS
cord-023417-by18aczt	363	7	of	of	IN
cord-023417-by18aczt	363	8	which	which	WDT
cord-023417-by18aczt	363	9	the	the	DT
cord-023417-by18aczt	363	10	A2a	A2a	NNP
cord-023417-by18aczt	363	11	receptor	receptor	NN
cord-023417-by18aczt	363	12	is	be	VBZ
cord-023417-by18aczt	363	13	the	the	DT
cord-023417-by18aczt	363	14	predominant	predominant	JJ
cord-023417-by18aczt	363	15	form	form	NN
cord-023417-by18aczt	363	16	in	in	IN
cord-023417-by18aczt	363	17	T	t	NN
cord-023417-by18aczt	363	18	cells	cell	NNS
cord-023417-by18aczt	363	19	.	.	.
cord-023417-by18aczt	364	1	Adenosine	adenosine	NN
cord-023417-by18aczt	364	2	levels	level	NNS
cord-023417-by18aczt	364	3	are	be	VBP
cord-023417-by18aczt	364	4	elevated	elevate	VBN
cord-023417-by18aczt	364	5	in	in	IN
cord-023417-by18aczt	364	6	asthmatic	asthmatic	JJ
cord-023417-by18aczt	364	7	lung	lung	NN
cord-023417-by18aczt	364	8	,	,	,
cord-023417-by18aczt	364	9	and	and	CC
cord-023417-by18aczt	364	10	adenosine	adenosine	NN
cord-023417-by18aczt	364	11	can	can	MD
cord-023417-by18aczt	364	12	directly	directly	RB
cord-023417-by18aczt	364	13	induce	induce	VB
cord-023417-by18aczt	364	14	mast	mast	JJ
cord-023417-by18aczt	364	15	cell	cell	NN
cord-023417-by18aczt	364	16	degranulation	degranulation	NN
cord-023417-by18aczt	364	17	and	and	CC
cord-023417-by18aczt	364	18	bronchoconstriction	bronchoconstriction	NN
cord-023417-by18aczt	364	19	in	in	IN
cord-023417-by18aczt	364	20	these	these	DT
cord-023417-by18aczt	364	21	patients	patient	NNS
cord-023417-by18aczt	364	22	.	.	.
cord-023417-by18aczt	365	1	Instead	instead	RB
cord-023417-by18aczt	365	2	,	,	,
cord-023417-by18aczt	365	3	the	the	DT
cord-023417-by18aczt	365	4	role	role	NN
cord-023417-by18aczt	365	5	of	of	IN
cord-023417-by18aczt	365	6	anti	anti	JJ
cord-023417-by18aczt	365	7	-	-	JJ
cord-023417-by18aczt	365	8	inflammatory	inflammatory	JJ
cord-023417-by18aczt	365	9	mechanisms	mechanism	NNS
cord-023417-by18aczt	365	10	of	of	IN
cord-023417-by18aczt	365	11	adenosine	adenosine	NN
cord-023417-by18aczt	365	12	on	on	IN
cord-023417-by18aczt	365	13	T	T	NNP
cord-023417-by18aczt	365	14	cells	cell	NNS
cord-023417-by18aczt	365	15	in	in	IN
cord-023417-by18aczt	365	16	asthma	asthma	NN
cord-023417-by18aczt	365	17	is	be	VBZ
cord-023417-by18aczt	365	18	unclear	unclear	JJ
cord-023417-by18aczt	365	19	.	.	.
cord-023417-by18aczt	366	1	Aim	aim	VB
cord-023417-by18aczt	366	2	:	:	:
cord-023417-by18aczt	366	3	To	to	TO
cord-023417-by18aczt	366	4	study	study	VB
cord-023417-by18aczt	366	5	the	the	DT
cord-023417-by18aczt	366	6	A2a	A2a	NNP
cord-023417-by18aczt	366	7	receptor	receptor	NN
cord-023417-by18aczt	366	8	expression	expression	NN
cord-023417-by18aczt	366	9	in	in	IN
cord-023417-by18aczt	366	10	peripheral	peripheral	JJ
cord-023417-by18aczt	366	11	blood	blood	NN
cord-023417-by18aczt	366	12	CD4	CD4	NNP
cord-023417-by18aczt	366	13	þ	þ	NNP
cord-023417-by18aczt	366	14	T	t	NN
cord-023417-by18aczt	366	15	cells	cell	NNS
cord-023417-by18aczt	366	16	in	in	IN
cord-023417-by18aczt	366	17	asthmatic	asthmatic	JJ
cord-023417-by18aczt	366	18	and	and	CC
cord-023417-by18aczt	366	19	healthy	healthy	JJ
cord-023417-by18aczt	366	20	individuals	individual	NNS
cord-023417-by18aczt	366	21	using	use	VBG
cord-023417-by18aczt	366	22	flow	flow	NN
cord-023417-by18aczt	366	23	cytometric	cytometric	JJ
cord-023417-by18aczt	366	24	and	and	CC
cord-023417-by18aczt	366	25	quantitative	quantitative	JJ
cord-023417-by18aczt	366	26	real	real	JJ
cord-023417-by18aczt	366	27	-	-	HYPH
cord-023417-by18aczt	366	28	time	time	NN
cord-023417-by18aczt	366	29	PCR	pcr	NN
cord-023417-by18aczt	366	30	methods	method	NNS
cord-023417-by18aczt	366	31	.	.	.
cord-023417-by18aczt	367	1	Results	result	NNS
cord-023417-by18aczt	367	2	:	:	:
cord-023417-by18aczt	368	1	Unstimulated	unstimulated	JJ
cord-023417-by18aczt	368	2	CD4	CD4	NNP
cord-023417-by18aczt	368	3	þ	þ	NNP
cord-023417-by18aczt	368	4	cells	cell	NNS
cord-023417-by18aczt	368	5	of	of	IN
cord-023417-by18aczt	368	6	asthmatic	asthmatic	JJ
cord-023417-by18aczt	368	7	patients	patient	NNS
cord-023417-by18aczt	368	8	expressed	express	VBD
cord-023417-by18aczt	368	9	significantly	significantly	RB
cord-023417-by18aczt	368	10	lower	low	JJR
cord-023417-by18aczt	368	11	levels	level	NNS
cord-023417-by18aczt	368	12	(	(	-LRB-
cord-023417-by18aczt	368	13	P	p	NN
cord-023417-by18aczt	368	14	<	<	XX
cord-023417-by18aczt	368	15	0.001	0.001	CD
cord-023417-by18aczt	368	16	)	)	-RRB-
cord-023417-by18aczt	368	17	of	of	IN
cord-023417-by18aczt	368	18	A2a	a2a	CD
cord-023417-by18aczt	368	19	receptor	receptor	NN
cord-023417-by18aczt	368	20	in	in	IN
cord-023417-by18aczt	368	21	protein	protein	NN
cord-023417-by18aczt	368	22	level	level	NN
cord-023417-by18aczt	368	23	(	(	-LRB-
cord-023417-by18aczt	368	24	mean	mean	JJ
cord-023417-by18aczt	368	25	percentage	percentage	NN
cord-023417-by18aczt	368	26	of	of	IN
cord-023417-by18aczt	368	27	cells	cell	NNS
cord-023417-by18aczt	368	28	positive	positive	JJ
cord-023417-by18aczt	368	29	AE	AE	NNP
cord-023417-by18aczt	368	30	SEM	SEM	NNP
cord-023417-by18aczt	368	31	:	:	:
cord-023417-by18aczt	368	32	76.8	76.8	CD
cord-023417-by18aczt	368	33	AE	AE	NNP
cord-023417-by18aczt	368	34	1.2	1.2	CD
cord-023417-by18aczt	368	35	,	,	,
cord-023417-by18aczt	368	36	n	n	NN
cord-023417-by18aczt	368	37	¼	¼	NNP
cord-023417-by18aczt	368	38	6	6	CD
cord-023417-by18aczt	368	39	)	)	-RRB-
cord-023417-by18aczt	368	40	compared	compare	VBN
cord-023417-by18aczt	368	41	to	to	IN
cord-023417-by18aczt	368	42	healthy	healthy	JJ
cord-023417-by18aczt	368	43	individuals	individual	NNS
cord-023417-by18aczt	368	44	(	(	-LRB-
cord-023417-by18aczt	368	45	90.4	90.4	CD
cord-023417-by18aczt	368	46	%	%	NN
cord-023417-by18aczt	368	47	AE	AE	NNP
cord-023417-by18aczt	368	48	1.9	1.9	CD
cord-023417-by18aczt	368	49	,	,	,
cord-023417-by18aczt	368	50	n	n	NN
cord-023417-by18aczt	368	51	¼	¼	NNP
cord-023417-by18aczt	368	52	4	4	CD
cord-023417-by18aczt	368	53	)	)	-RRB-
cord-023417-by18aczt	368	54	.	.	.
cord-023417-by18aczt	369	1	Double	double	JJ
cord-023417-by18aczt	369	2	staining	staining	NN
cord-023417-by18aczt	369	3	for	for	IN
cord-023417-by18aczt	369	4	CD69	CD69	NNP
cord-023417-by18aczt	369	5	expression	expression	NN
cord-023417-by18aczt	369	6	showed	show	VBD
cord-023417-by18aczt	369	7	that	that	IN
cord-023417-by18aczt	369	8	stimulation	stimulation	NN
cord-023417-by18aczt	369	9	of	of	IN
cord-023417-by18aczt	369	10	CD4	CD4	NNP
cord-023417-by18aczt	369	11	þ	þ	NNP
cord-023417-by18aczt	369	12	cells	cell	NNS
cord-023417-by18aczt	369	13	decreased	decrease	VBD
cord-023417-by18aczt	369	14	A2a	a2a	DT
cord-023417-by18aczt	369	15	expression	expression	NN
cord-023417-by18aczt	369	16	in	in	IN
cord-023417-by18aczt	369	17	both	both	DT
cord-023417-by18aczt	369	18	groups	group	NNS
cord-023417-by18aczt	369	19	but	but	CC
cord-023417-by18aczt	369	20	indicated	indicate	VBD
cord-023417-by18aczt	369	21	that	that	IN
cord-023417-by18aczt	369	22	the	the	DT
cord-023417-by18aczt	369	23	detected	detect	VBN
cord-023417-by18aczt	369	24	lower	low	JJR
cord-023417-by18aczt	369	25	levels	level	NNS
cord-023417-by18aczt	369	26	of	of	IN
cord-023417-by18aczt	369	27	A2a	a2a	CD
cord-023417-by18aczt	369	28	in	in	IN
cord-023417-by18aczt	369	29	unstimulated	unstimulated	JJ
cord-023417-by18aczt	369	30	cells	cell	NNS
cord-023417-by18aczt	369	31	of	of	IN
cord-023417-by18aczt	369	32	asthmatics	asthmatic	NNS
cord-023417-by18aczt	369	33	was	be	VBD
cord-023417-by18aczt	369	34	not	not	RB
cord-023417-by18aczt	369	35	due	due	JJ
cord-023417-by18aczt	369	36	to	to	IN
cord-023417-by18aczt	369	37	preactivation	preactivation	NN
cord-023417-by18aczt	369	38	in	in	IN
cord-023417-by18aczt	369	39	these	these	DT
cord-023417-by18aczt	369	40	patients	patient	NNS
cord-023417-by18aczt	369	41	.	.	.
cord-023417-by18aczt	370	1	Surprisingly	surprisingly	RB
cord-023417-by18aczt	370	2	,	,	,
cord-023417-by18aczt	370	3	A2a	a2a	DT
cord-023417-by18aczt	370	4	mRNA	mrna	NN
cord-023417-by18aczt	370	5	expression	expression	NN
cord-023417-by18aczt	370	6	in	in	IN
cord-023417-by18aczt	370	7	unstimulated	unstimulated	JJ
cord-023417-by18aczt	370	8	CD4	CD4	NNP
cord-023417-by18aczt	370	9	þ	þ	NNP
cord-023417-by18aczt	370	10	cells	cell	NNS
cord-023417-by18aczt	370	11	was	be	VBD
cord-023417-by18aczt	370	12	significantly	significantly	RB
cord-023417-by18aczt	370	13	higher	high	JJR
cord-023417-by18aczt	370	14	(	(	-LRB-
cord-023417-by18aczt	370	15	P	p	NN
cord-023417-by18aczt	370	16	<	<	XX
cord-023417-by18aczt	370	17	0.05	0.05	CD
cord-023417-by18aczt	370	18	)	)	-RRB-
cord-023417-by18aczt	370	19	in	in	IN
cord-023417-by18aczt	370	20	asthmatics	asthmatic	NNS
cord-023417-by18aczt	370	21	(	(	-LRB-
cord-023417-by18aczt	370	22	n	n	CC
cord-023417-by18aczt	370	23	¼	¼	NNP
cord-023417-by18aczt	370	24	28	28	CD
cord-023417-by18aczt	370	25	)	)	-RRB-
cord-023417-by18aczt	370	26	compared	compare	VBN
cord-023417-by18aczt	370	27	to	to	IN
cord-023417-by18aczt	370	28	healthy	healthy	JJ
cord-023417-by18aczt	370	29	controls	control	NNS
cord-023417-by18aczt	370	30	(	(	-LRB-
cord-023417-by18aczt	370	31	n	n	CC
cord-023417-by18aczt	370	32	¼	¼	NNP
cord-023417-by18aczt	370	33	7	7	CD
cord-023417-by18aczt	370	34	)	)	-RRB-
cord-023417-by18aczt	370	35	.	.	.
cord-023417-by18aczt	371	1	The	the	DT
cord-023417-by18aczt	371	2	expression	expression	NN
cord-023417-by18aczt	371	3	did	do	VBD
cord-023417-by18aczt	371	4	not	not	RB
cord-023417-by18aczt	371	5	correlate	correlate	VB
cord-023417-by18aczt	371	6	with	with	IN
cord-023417-by18aczt	371	7	serum	serum	NNP
cord-023417-by18aczt	371	8	total	total	JJ
cord-023417-by18aczt	371	9	IgE	IgE	NNP
cord-023417-by18aczt	371	10	levels	level	NNS
cord-023417-by18aczt	371	11	.	.	.
cord-023417-by18aczt	372	1	Conclusions	conclusion	NNS
cord-023417-by18aczt	372	2	:	:	:
cord-023417-by18aczt	373	1	Asthmatic	asthmatic	JJ
cord-023417-by18aczt	373	2	individuals	individual	NNS
cord-023417-by18aczt	373	3	express	express	VBP
cord-023417-by18aczt	373	4	less	less	RBR
cord-023417-by18aczt	373	5	A2a	a2a	CD
cord-023417-by18aczt	373	6	adenosine	adenosine	NN
cord-023417-by18aczt	373	7	receptor	receptor	NN
cord-023417-by18aczt	373	8	on	on	IN
cord-023417-by18aczt	373	9	their	-PRON-	PRP$
cord-023417-by18aczt	373	10	peripheral	peripheral	JJ
cord-023417-by18aczt	373	11	CD4	CD4	NNP
cord-023417-by18aczt	373	12	þ	þ	NNP
cord-023417-by18aczt	373	13	T	t	NN
cord-023417-by18aczt	373	14	cells	cell	NNS
cord-023417-by18aczt	373	15	.	.	.
cord-023417-by18aczt	374	1	The	the	DT
cord-023417-by18aczt	374	2	higher	high	JJR
cord-023417-by18aczt	374	3	mRNA	mrna	NN
cord-023417-by18aczt	374	4	levels	level	NNS
cord-023417-by18aczt	374	5	instead	instead	RB
cord-023417-by18aczt	374	6	may	may	MD
cord-023417-by18aczt	374	7	point	point	VB
cord-023417-by18aczt	374	8	to	to	IN
cord-023417-by18aczt	374	9	a	a	DT
cord-023417-by18aczt	374	10	negative	negative	JJ
cord-023417-by18aczt	374	11	feedback	feedback	NN
cord-023417-by18aczt	374	12	regulation	regulation	NN
cord-023417-by18aczt	374	13	in	in	IN
cord-023417-by18aczt	374	14	the	the	DT
cord-023417-by18aczt	374	15	receptor	receptor	NN
cord-023417-by18aczt	374	16	expression	expression	NN
cord-023417-by18aczt	374	17	.	.	.
cord-023417-by18aczt	375	1	The	the	DT
cord-023417-by18aczt	375	2	role	role	NN
cord-023417-by18aczt	375	3	of	of	IN
cord-023417-by18aczt	375	4	possibly	possibly	RB
cord-023417-by18aczt	375	5	decreased	decrease	VBD
cord-023417-by18aczt	375	6	adenosine	adenosine	NN
cord-023417-by18aczt	375	7	-	-	HYPH
cord-023417-by18aczt	375	8	mediated	mediate	VBN
cord-023417-by18aczt	375	9	anti	anti	JJ
cord-023417-by18aczt	375	10	-	-	JJ
cord-023417-by18aczt	375	11	inflammatory	inflammatory	JJ
cord-023417-by18aczt	375	12	effects	effect	NNS
cord-023417-by18aczt	375	13	in	in	IN
cord-023417-by18aczt	375	14	asthma	asthma	NN
cord-023417-by18aczt	375	15	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	375	16	require	require	VBP
cord-023417-by18aczt	375	17	further	further	JJ
cord-023417-by18aczt	375	18	studies	study	NNS
cord-023417-by18aczt	375	19	on	on	IN
cord-023417-by18aczt	375	20	this	this	DT
cord-023417-by18aczt	375	21	T	t	NN
cord-023417-by18aczt	375	22	-	-	HYPH
cord-023417-by18aczt	375	23	cell	cell	NN
cord-023417-by18aczt	375	24	mediated	mediate	VBN
cord-023417-by18aczt	375	25	disease	disease	NN
cord-023417-by18aczt	375	26	.	.	.
cord-023417-by18aczt	376	1	The	the	DT
cord-023417-by18aczt	376	2	chronic	chronic	JJ
cord-023417-by18aczt	376	3	inflammatory	inflammatory	JJ
cord-023417-by18aczt	376	4	skin	skin	NN
cord-023417-by18aczt	376	5	disease	disease	NN
cord-023417-by18aczt	376	6	atopic	atopic	NN
cord-023417-by18aczt	376	7	eczema	eczema	NN
cord-023417-by18aczt	376	8	(	(	-LRB-
cord-023417-by18aczt	376	9	AE	AE	NNP
cord-023417-by18aczt	376	10	)	)	-RRB-
cord-023417-by18aczt	376	11	affects	affect	VBZ
cord-023417-by18aczt	376	12	almost	almost	RB
cord-023417-by18aczt	376	13	15	15	CD
cord-023417-by18aczt	376	14	%	%	NN
cord-023417-by18aczt	376	15	of	of	IN
cord-023417-by18aczt	376	16	the	the	DT
cord-023417-by18aczt	376	17	population	population	NN
cord-023417-by18aczt	376	18	in	in	IN
cord-023417-by18aczt	376	19	many	many	JJ
cord-023417-by18aczt	376	20	countries	country	NNS
cord-023417-by18aczt	376	21	today	today	NN
cord-023417-by18aczt	376	22	.	.	.
cord-023417-by18aczt	377	1	The	the	DT
cord-023417-by18aczt	377	2	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	377	3	of	of	IN
cord-023417-by18aczt	377	4	AE	AE	NNP
cord-023417-by18aczt	377	5	is	be	VBZ
cord-023417-by18aczt	377	6	not	not	RB
cord-023417-by18aczt	377	7	fully	fully	RB
cord-023417-by18aczt	377	8	understood	understand	VBN
cord-023417-by18aczt	377	9	.	.	.
cord-023417-by18aczt	378	1	A	a	DT
cord-023417-by18aczt	378	2	combination	combination	NN
cord-023417-by18aczt	378	3	of	of	IN
cord-023417-by18aczt	378	4	genetic	genetic	JJ
cord-023417-by18aczt	378	5	predisposition	predisposition	NN
cord-023417-by18aczt	378	6	and	and	CC
cord-023417-by18aczt	378	7	environmental	environmental	JJ
cord-023417-by18aczt	378	8	factors	factor	NNS
cord-023417-by18aczt	378	9	like	like	IN
cord-023417-by18aczt	378	10	microorganisms	microorganism	NNS
cord-023417-by18aczt	378	11	seems	seem	VBZ
cord-023417-by18aczt	378	12	to	to	TO
cord-023417-by18aczt	378	13	contribute	contribute	VB
cord-023417-by18aczt	378	14	to	to	IN
cord-023417-by18aczt	378	15	the	the	DT
cord-023417-by18aczt	378	16	symptoms	symptom	NNS
cord-023417-by18aczt	378	17	.	.	.
cord-023417-by18aczt	379	1	The	the	DT
cord-023417-by18aczt	379	2	yeast	yeast	NN
cord-023417-by18aczt	379	3	Malassezia	Malassezia	NNP
cord-023417-by18aczt	379	4	sympodialis	sympodialis	NNP
cord-023417-by18aczt	379	5	is	be	VBZ
cord-023417-by18aczt	379	6	part	part	NN
cord-023417-by18aczt	379	7	of	of	IN
cord-023417-by18aczt	379	8	our	-PRON-	PRP$
cord-023417-by18aczt	379	9	normal	normal	JJ
cord-023417-by18aczt	379	10	skin	skin	NN
cord-023417-by18aczt	379	11	micro	micro	NN
cord-023417-by18aczt	379	12	flora	flora	NN
cord-023417-by18aczt	379	13	but	but	CC
cord-023417-by18aczt	379	14	can	can	MD
cord-023417-by18aczt	379	15	act	act	VB
cord-023417-by18aczt	379	16	as	as	IN
cord-023417-by18aczt	379	17	an	an	DT
cord-023417-by18aczt	379	18	allergen	allergen	NN
cord-023417-by18aczt	379	19	and	and	CC
cord-023417-by18aczt	379	20	elicit	elicit	VB
cord-023417-by18aczt	379	21	specific	specific	JJ
cord-023417-by18aczt	379	22	IgE	IgE	NNP
cord-023417-by18aczt	379	23	and	and	CC
cord-023417-by18aczt	379	24	T	t	NN
cord-023417-by18aczt	379	25	-	-	HYPH
cord-023417-by18aczt	379	26	cell	cell	NN
cord-023417-by18aczt	379	27	reactivity	reactivity	NN
cord-023417-by18aczt	379	28	in	in	IN
cord-023417-by18aczt	379	29	patients	patient	NNS
cord-023417-by18aczt	379	30	with	with	IN
cord-023417-by18aczt	379	31	AE	AE	NNP
cord-023417-by18aczt	379	32	.	.	.
cord-023417-by18aczt	380	1	Recently	recently	RB
cord-023417-by18aczt	380	2	,	,	,
cord-023417-by18aczt	380	3	we	-PRON-	PRP
cord-023417-by18aczt	380	4	identified	identify	VBD
cord-023417-by18aczt	380	5	a	a	DT
cord-023417-by18aczt	380	6	novel	novel	JJ
cord-023417-by18aczt	380	7	major	major	JJ
cord-023417-by18aczt	380	8	M.	M.	NNP
cord-023417-by18aczt	380	9	sympodialis	sympodialis	JJ
cord-023417-by18aczt	380	10	allergen	allergen	NN
cord-023417-by18aczt	380	11	,	,	,
cord-023417-by18aczt	380	12	designated	designate	VBN
cord-023417-by18aczt	380	13	Mala	Mala	NNP
cord-023417-by18aczt	380	14	s	s	POS
cord-023417-by18aczt	380	15	11	11	CD
cord-023417-by18aczt	380	16	(	(	-LRB-
cord-023417-by18aczt	380	17	22.4	22.4	CD
cord-023417-by18aczt	380	18	kDa	kDa	NNPS
cord-023417-by18aczt	380	19	)	)	-RRB-
cord-023417-by18aczt	380	20	,	,	,
cord-023417-by18aczt	380	21	with	with	IN
cord-023417-by18aczt	380	22	sequence	sequence	NN
cord-023417-by18aczt	380	23	similarity	similarity	NN
cord-023417-by18aczt	380	24	to	to	IN
cord-023417-by18aczt	380	25	the	the	DT
cord-023417-by18aczt	380	26	mitochondrial	mitochondrial	JJ
cord-023417-by18aczt	380	27	enzyme	enzyme	NN
cord-023417-by18aczt	380	28	manganese	manganese	NN
cord-023417-by18aczt	380	29	superoxide	superoxide	NN
cord-023417-by18aczt	380	30	dismutase	dismutase	NN
cord-023417-by18aczt	380	31	(	(	-LRB-
cord-023417-by18aczt	380	32	MnSOD	MnSOD	NNP
cord-023417-by18aczt	380	33	)	)	-RRB-
cord-023417-by18aczt	380	34	.	.	.
cord-023417-by18aczt	381	1	Interestingly	interestingly	RB
cord-023417-by18aczt	381	2	,	,	,
cord-023417-by18aczt	381	3	Mala	Mala	NNP
cord-023417-by18aczt	381	4	s	s	POS
cord-023417-by18aczt	381	5	11	11	CD
cord-023417-by18aczt	381	6	has	have	VBZ
cord-023417-by18aczt	381	7	a	a	DT
cord-023417-by18aczt	381	8	high	high	JJ
cord-023417-by18aczt	381	9	degree	degree	NN
cord-023417-by18aczt	381	10	of	of	IN
cord-023417-by18aczt	381	11	homology	homology	NN
cord-023417-by18aczt	381	12	to	to	IN
cord-023417-by18aczt	381	13	human	human	JJ
cord-023417-by18aczt	381	14	MnSOD	MnSOD	NNP
cord-023417-by18aczt	381	15	.	.	.
cord-023417-by18aczt	382	1	The	the	DT
cord-023417-by18aczt	382	2	aim	aim	NN
cord-023417-by18aczt	382	3	of	of	IN
cord-023417-by18aczt	382	4	this	this	DT
cord-023417-by18aczt	382	5	study	study	NN
cord-023417-by18aczt	382	6	was	be	VBD
cord-023417-by18aczt	382	7	to	to	TO
cord-023417-by18aczt	382	8	examine	examine	VB
cord-023417-by18aczt	382	9	the	the	DT
cord-023417-by18aczt	382	10	effects	effect	NNS
cord-023417-by18aczt	382	11	of	of	IN
cord-023417-by18aczt	382	12	recombinant	recombinant	JJ
cord-023417-by18aczt	382	13	Mala	Mala	NNP
cord-023417-by18aczt	382	14	s	s	POS
cord-023417-by18aczt	382	15	11	11	CD
cord-023417-by18aczt	382	16	on	on	IN
cord-023417-by18aczt	382	17	antigen	antigen	NN
cord-023417-by18aczt	382	18	-	-	HYPH
cord-023417-by18aczt	382	19	presenting	present	VBG
cord-023417-by18aczt	382	20	dendritic	dendritic	JJ
cord-023417-by18aczt	382	21	cells	cell	NNS
cord-023417-by18aczt	382	22	.	.	.
cord-023417-by18aczt	383	1	Monocytederived	monocytederived	JJ
cord-023417-by18aczt	383	2	dendritic	dendritic	JJ
cord-023417-by18aczt	383	3	cells	cell	NNS
cord-023417-by18aczt	383	4	(	(	-LRB-
cord-023417-by18aczt	383	5	MDDCs	mddc	NNS
cord-023417-by18aczt	383	6	)	)	-RRB-
cord-023417-by18aczt	383	7	from	from	IN
cord-023417-by18aczt	383	8	healthy	healthy	JJ
cord-023417-by18aczt	383	9	blood	blood	NN
cord-023417-by18aczt	383	10	donors	donor	NNS
cord-023417-by18aczt	383	11	were	be	VBD
cord-023417-by18aczt	383	12	cultured	culture	VBN
cord-023417-by18aczt	383	13	with	with	IN
cord-023417-by18aczt	383	14	or	or	CC
cord-023417-by18aczt	383	15	without	without	IN
cord-023417-by18aczt	383	16	Mala	Mala	NNP
cord-023417-by18aczt	383	17	s	s	NNP
cord-023417-by18aczt	383	18	11	11	CD
cord-023417-by18aczt	383	19	for	for	IN
cord-023417-by18aczt	383	20	different	different	JJ
cord-023417-by18aczt	383	21	time	time	NN
cord-023417-by18aczt	383	22	periods	period	NNS
cord-023417-by18aczt	383	23	.	.	.
cord-023417-by18aczt	384	1	It	-PRON-	PRP
cord-023417-by18aczt	384	2	was	be	VBD
cord-023417-by18aczt	384	3	found	find	VBN
cord-023417-by18aczt	384	4	that	that	IN
cord-023417-by18aczt	384	5	the	the	DT
cord-023417-by18aczt	384	6	maturation	maturation	NN
cord-023417-by18aczt	384	7	marker	marker	NN
cord-023417-by18aczt	384	8	CD83	CD83	NNP
cord-023417-by18aczt	384	9	and	and	CC
cord-023417-by18aczt	384	10	the	the	DT
cord-023417-by18aczt	384	11	costimulatory	costimulatory	NN
cord-023417-by18aczt	384	12	molecules	molecule	NNS
cord-023417-by18aczt	384	13	CD80	CD80	NNP
cord-023417-by18aczt	384	14	and	and	CC
cord-023417-by18aczt	384	15	CD86	CD86	NNP
cord-023417-by18aczt	384	16	were	be	VBD
cord-023417-by18aczt	384	17	upregulated	upregulate	VBN
cord-023417-by18aczt	384	18	on	on	IN
cord-023417-by18aczt	384	19	the	the	DT
cord-023417-by18aczt	384	20	MDDCs	mddc	NNS
cord-023417-by18aczt	384	21	exposed	expose	VBN
cord-023417-by18aczt	384	22	to	to	IN
cord-023417-by18aczt	384	23	Mala	Mala	NNP
cord-023417-by18aczt	384	24	s	s	NNP
cord-023417-by18aczt	384	25	11	11	CD
cord-023417-by18aczt	384	26	for	for	IN
cord-023417-by18aczt	384	27	24	24	CD
cord-023417-by18aczt	384	28	h	h	NNP
cord-023417-by18aczt	384	29	,	,	,
cord-023417-by18aczt	384	30	as	as	IN
cord-023417-by18aczt	384	31	demonstrated	demonstrate	VBN
cord-023417-by18aczt	384	32	by	by	IN
cord-023417-by18aczt	384	33	flow	flow	NN
cord-023417-by18aczt	384	34	cytometry	cytometry	NN
cord-023417-by18aczt	384	35	.	.	.
cord-023417-by18aczt	385	1	Furthermore	furthermore	RB
cord-023417-by18aczt	385	2	,	,	,
cord-023417-by18aczt	385	3	coculture	coculture	NN
cord-023417-by18aczt	385	4	of	of	IN
cord-023417-by18aczt	385	5	MDDCs	mddc	NNS
cord-023417-by18aczt	385	6	with	with	IN
cord-023417-by18aczt	385	7	Mala	Mala	NNP
cord-023417-by18aczt	385	8	s	s	NNP
cord-023417-by18aczt	385	9	11	11	CD
cord-023417-by18aczt	385	10	for	for	IN
cord-023417-by18aczt	385	11	9	9	CD
cord-023417-by18aczt	385	12	h	h	NN
cord-023417-by18aczt	385	13	induced	induce	VBD
cord-023417-by18aczt	385	14	an	an	DT
cord-023417-by18aczt	385	15	increased	increase	VBN
cord-023417-by18aczt	385	16	production	production	NN
cord-023417-by18aczt	385	17	of	of	IN
cord-023417-by18aczt	385	18	the	the	DT
cord-023417-by18aczt	385	19	inflammatory	inflammatory	JJ
cord-023417-by18aczt	385	20	cytokines	cytokine	NNS
cord-023417-by18aczt	385	21	IL-6	IL-6	NNP
cord-023417-by18aczt	385	22	(	(	-LRB-
cord-023417-by18aczt	385	23	200-fold	200-fold	CD
cord-023417-by18aczt	385	24	)	)	-RRB-
cord-023417-by18aczt	385	25	,	,	,
cord-023417-by18aczt	385	26	TNF	TNF	NNP
cord-023417-by18aczt	385	27	-	-	,
cord-023417-by18aczt	385	28	a	a	NNP
cord-023417-by18aczt	385	29	(	(	-LRB-
cord-023417-by18aczt	385	30	100-fold	100-fold	CD
cord-023417-by18aczt	385	31	)	)	-RRB-
cord-023417-by18aczt	385	32	and	and	CC
cord-023417-by18aczt	385	33	IL-8	IL-8	NNP
cord-023417-by18aczt	385	34	(	(	-LRB-
cord-023417-by18aczt	385	35	sixfold	sixfold	RB
cord-023417-by18aczt	385	36	)	)	-RRB-
cord-023417-by18aczt	385	37	,	,	,
cord-023417-by18aczt	385	38	as	as	IN
cord-023417-by18aczt	385	39	detected	detect	VBN
cord-023417-by18aczt	385	40	by	by	IN
cord-023417-by18aczt	385	41	the	the	DT
cord-023417-by18aczt	385	42	cytometric	cytometric	NNP
cord-023417-by18aczt	385	43	bead	bead	NN
cord-023417-by18aczt	385	44	array	array	NN
cord-023417-by18aczt	385	45	(	(	-LRB-
cord-023417-by18aczt	385	46	CBA	CBA	NNP
cord-023417-by18aczt	385	47	)	)	-RRB-
cord-023417-by18aczt	385	48	analysis	analysis	NN
cord-023417-by18aczt	385	49	.	.	.
cord-023417-by18aczt	386	1	Our	-PRON-	PRP$
cord-023417-by18aczt	386	2	results	result	NNS
cord-023417-by18aczt	386	3	suggest	suggest	VBP
cord-023417-by18aczt	386	4	that	that	IN
cord-023417-by18aczt	386	5	Mala	Mala	NNP
cord-023417-by18aczt	386	6	s	s	POS
cord-023417-by18aczt	386	7	11	11	CD
cord-023417-by18aczt	386	8	affects	affect	VBZ
cord-023417-by18aczt	386	9	the	the	DT
cord-023417-by18aczt	386	10	immune	immune	JJ
cord-023417-by18aczt	386	11	response	response	NN
cord-023417-by18aczt	386	12	through	through	IN
cord-023417-by18aczt	386	13	DC	DC	NNP
cord-023417-by18aczt	386	14	maturation	maturation	NN
cord-023417-by18aczt	386	15	and	and	CC
cord-023417-by18aczt	386	16	production	production	NN
cord-023417-by18aczt	386	17	of	of	IN
cord-023417-by18aczt	386	18	inflammatory	inflammatory	JJ
cord-023417-by18aczt	386	19	cytokines	cytokine	NNS
cord-023417-by18aczt	386	20	.	.	.
cord-023417-by18aczt	387	1	The	the	DT
cord-023417-by18aczt	387	2	potential	potential	JJ
cord-023417-by18aczt	387	3	cross	cross	NN
cord-023417-by18aczt	387	4	-	-	NN
cord-023417-by18aczt	387	5	reactivity	reactivity	NN
cord-023417-by18aczt	387	6	with	with	IN
cord-023417-by18aczt	387	7	human	human	JJ
cord-023417-by18aczt	387	8	MnSOD	MnSOD	NNP
cord-023417-by18aczt	387	9	needs	need	NNS
cord-023417-by18aczt	387	10	to	to	TO
cord-023417-by18aczt	387	11	be	be	VB
cord-023417-by18aczt	387	12	explored	explore	VBN
cord-023417-by18aczt	387	13	and	and	CC
cord-023417-by18aczt	387	14	the	the	DT
cord-023417-by18aczt	387	15	exact	exact	JJ
cord-023417-by18aczt	387	16	role	role	NN
cord-023417-by18aczt	387	17	of	of	IN
cord-023417-by18aczt	387	18	Mala	Mala	NNP
cord-023417-by18aczt	387	19	s	s	NNP
cord-023417-by18aczt	387	20	11	11	CD
cord-023417-by18aczt	387	21	in	in	IN
cord-023417-by18aczt	387	22	the	the	DT
cord-023417-by18aczt	387	23	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	387	24	of	of	IN
cord-023417-by18aczt	387	25	AE	AE	NNP
cord-023417-by18aczt	387	26	assessed	assess	VBN
cord-023417-by18aczt	387	27	in	in	IN
cord-023417-by18aczt	387	28	clinical	clinical	JJ
cord-023417-by18aczt	387	29	studies	study	NNS
cord-023417-by18aczt	387	30	involving	involve	VBG
cord-023417-by18aczt	387	31	skin	skin	NN
cord-023417-by18aczt	387	32	prick	prick	NN
cord-023417-by18aczt	387	33	and	and	CC
cord-023417-by18aczt	387	34	atopy	atopy	NN
cord-023417-by18aczt	387	35	patch	patch	NN
cord-023417-by18aczt	387	36	tests	test	NNS
cord-023417-by18aczt	387	37	.	.	.
cord-023417-by18aczt	388	1	Allergen	allergen	NN
cord-023417-by18aczt	388	2	-	-	HYPH
cord-023417-by18aczt	388	3	specific	specific	JJ
cord-023417-by18aczt	388	4	immunotherapy	immunotherapy	NN
cord-023417-by18aczt	388	5	(	(	-LRB-
cord-023417-by18aczt	388	6	SIT	sit	NN
cord-023417-by18aczt	388	7	)	)	-RRB-
cord-023417-by18aczt	388	8	is	be	VBZ
cord-023417-by18aczt	388	9	commonly	commonly	RB
cord-023417-by18aczt	388	10	conducted	conduct	VBN
cord-023417-by18aczt	388	11	with	with	IN
cord-023417-by18aczt	388	12	allergen	allergen	NN
cord-023417-by18aczt	388	13	extracts	extract	NNS
cord-023417-by18aczt	388	14	adsorbed	adsorb	VBN
cord-023417-by18aczt	388	15	to	to	IN
cord-023417-by18aczt	388	16	aluminium	aluminium	NN
cord-023417-by18aczt	388	17	hydroxide	hydroxide	NN
cord-023417-by18aczt	388	18	(	(	-LRB-
cord-023417-by18aczt	388	19	alum	alum	NN
cord-023417-by18aczt	388	20	)	)	-RRB-
cord-023417-by18aczt	388	21	.	.	.
cord-023417-by18aczt	389	1	Drawbacks	drawback	NNS
cord-023417-by18aczt	389	2	linked	link	VBN
cord-023417-by18aczt	389	3	to	to	IN
cord-023417-by18aczt	389	4	the	the	DT
cord-023417-by18aczt	389	5	use	use	NN
cord-023417-by18aczt	389	6	of	of	IN
cord-023417-by18aczt	389	7	alum	alum	NN
cord-023417-by18aczt	389	8	,	,	,
cord-023417-by18aczt	389	9	such	such	JJ
cord-023417-by18aczt	389	10	as	as	IN
cord-023417-by18aczt	389	11	the	the	DT
cord-023417-by18aczt	389	12	formation	formation	NN
cord-023417-by18aczt	389	13	of	of	IN
cord-023417-by18aczt	389	14	granuloma	granuloma	NN
cord-023417-by18aczt	389	15	at	at	IN
cord-023417-by18aczt	389	16	the	the	DT
cord-023417-by18aczt	389	17	site	site	NN
cord-023417-by18aczt	389	18	of	of	IN
cord-023417-by18aczt	389	19	injection	injection	NN
cord-023417-by18aczt	389	20	,	,	,
cord-023417-by18aczt	389	21	have	have	VBP
cord-023417-by18aczt	389	22	led	lead	VBN
cord-023417-by18aczt	389	23	to	to	IN
cord-023417-by18aczt	389	24	suggestions	suggestion	NNS
cord-023417-by18aczt	389	25	of	of	IN
cord-023417-by18aczt	389	26	novel	novel	JJ
cord-023417-by18aczt	389	27	allergen	allergen	NN
cord-023417-by18aczt	389	28	carriers	carrier	NNS
cord-023417-by18aczt	389	29	.	.	.
cord-023417-by18aczt	390	1	An	an	DT
cord-023417-by18aczt	390	2	alternative	alternative	JJ
cord-023417-by18aczt	390	3	carrier	carrier	NN
cord-023417-by18aczt	390	4	is	be	VBZ
cord-023417-by18aczt	390	5	2	2	CD
cord-023417-by18aczt	390	6	mm	mm	NN
cord-023417-by18aczt	390	7	carbohydrate	carbohydrate	NN
cord-023417-by18aczt	390	8	-	-	HYPH
cord-023417-by18aczt	390	9	based	base	VBN
cord-023417-by18aczt	390	10	particles	particle	NNS
cord-023417-by18aczt	390	11	(	(	-LRB-
cord-023417-by18aczt	390	12	CBPs	CBPs	NNP
cord-023417-by18aczt	390	13	)	)	-RRB-
cord-023417-by18aczt	390	14	.	.	.
cord-023417-by18aczt	391	1	In	in	IN
cord-023417-by18aczt	391	2	mouse	mouse	NN
cord-023417-by18aczt	391	3	,	,	,
cord-023417-by18aczt	391	4	allergen	allergen	NN
cord-023417-by18aczt	391	5	-	-	HYPH
cord-023417-by18aczt	391	6	coupled	couple	VBN
cord-023417-by18aczt	391	7	CBPs	cbp	NNS
cord-023417-by18aczt	391	8	have	have	VBP
cord-023417-by18aczt	391	9	been	be	VBN
cord-023417-by18aczt	391	10	demonstrated	demonstrate	VBN
cord-023417-by18aczt	391	11	to	to	TO
cord-023417-by18aczt	391	12	skew	skew	VB
cord-023417-by18aczt	391	13	the	the	DT
cord-023417-by18aczt	391	14	allergen	allergen	NN
cord-023417-by18aczt	391	15	-	-	HYPH
cord-023417-by18aczt	391	16	specific	specific	JJ
cord-023417-by18aczt	391	17	immune	immune	JJ
cord-023417-by18aczt	391	18	response	response	NN
cord-023417-by18aczt	391	19	towards	towards	IN
cord-023417-by18aczt	391	20	a	a	DT
cord-023417-by18aczt	391	21	Th1-like	th1-like	JJ
cord-023417-by18aczt	391	22	activity	activity	NN
cord-023417-by18aczt	391	23	(	(	-LRB-
cord-023417-by18aczt	391	24	Grönlund	Grönlund	NNP
cord-023417-by18aczt	391	25	et	et	FW
cord-023417-by18aczt	391	26	al	al	NNP
cord-023417-by18aczt	391	27	.	.	.
cord-023417-by18aczt	392	1	Immunology	Immunology	NNP
cord-023417-by18aczt	392	2	,	,	,
cord-023417-by18aczt	392	3	2002	2002	CD
cord-023417-by18aczt	392	4	)	)	-RRB-
cord-023417-by18aczt	392	5	.	.	.
cord-023417-by18aczt	393	1	We	-PRON-	PRP
cord-023417-by18aczt	393	2	here	here	RB
cord-023417-by18aczt	393	3	coupled	couple	VBD
cord-023417-by18aczt	393	4	the	the	DT
cord-023417-by18aczt	393	5	recombinant	recombinant	JJ
cord-023417-by18aczt	393	6	major	major	JJ
cord-023417-by18aczt	393	7	cat	cat	NN
cord-023417-by18aczt	393	8	allergen	allergen	NN
cord-023417-by18aczt	393	9	Fel	Fel	NNP
cord-023417-by18aczt	393	10	d	d	NNP
cord-023417-by18aczt	393	11	1	1	CD
cord-023417-by18aczt	393	12	to	to	IN
cord-023417-by18aczt	393	13	CBPs	CBPs	NNP
cord-023417-by18aczt	393	14	(	(	-LRB-
cord-023417-by18aczt	393	15	CBP	CBP	NNP
cord-023417-by18aczt	393	16	-	-	HYPH
cord-023417-by18aczt	393	17	Fel	Fel	NNP
cord-023417-by18aczt	393	18	d	d	NN
cord-023417-by18aczt	393	19	1	1	CD
cord-023417-by18aczt	393	20	)	)	-RRB-
cord-023417-by18aczt	393	21	by	by	IN
cord-023417-by18aczt	393	22	cyanogen	cyanogen	NN
cord-023417-by18aczt	393	23	-	-	HYPH
cord-023417-by18aczt	393	24	bromide	bromide	NN
cord-023417-by18aczt	393	25	activation	activation	NN
cord-023417-by18aczt	393	26	,	,	,
cord-023417-by18aczt	393	27	resulting	result	VBG
cord-023417-by18aczt	393	28	in	in	IN
cord-023417-by18aczt	393	29	covalent	covalent	JJ
cord-023417-by18aczt	393	30	binding	binding	NN
cord-023417-by18aczt	393	31	.	.	.
cord-023417-by18aczt	394	1	The	the	DT
cord-023417-by18aczt	394	2	effect	effect	NN
cord-023417-by18aczt	394	3	of	of	IN
cord-023417-by18aczt	394	4	CBP	CBP	NNP
cord-023417-by18aczt	394	5	-	-	HYPH
cord-023417-by18aczt	394	6	Fel	Fel	NNP
cord-023417-by18aczt	394	7	d	d	NNP
cord-023417-by18aczt	394	8	1	1	CD
cord-023417-by18aczt	394	9	on	on	IN
cord-023417-by18aczt	394	10	monocyte	monocyte	NNP
cord-023417-by18aczt	394	11	-	-	HYPH
cord-023417-by18aczt	394	12	derived	derive	VBN
cord-023417-by18aczt	394	13	dendritic	dendritic	JJ
cord-023417-by18aczt	394	14	cells	cell	NNS
cord-023417-by18aczt	394	15	(	(	-LRB-
cord-023417-by18aczt	394	16	MDDCs	mddc	NNS
cord-023417-by18aczt	394	17	)	)	-RRB-
cord-023417-by18aczt	394	18	from	from	IN
cord-023417-by18aczt	394	19	healthy	healthy	JJ
cord-023417-by18aczt	394	20	human	human	JJ
cord-023417-by18aczt	394	21	blood	blood	NN
cord-023417-by18aczt	394	22	donors	donor	NNS
cord-023417-by18aczt	394	23	was	be	VBD
cord-023417-by18aczt	394	24	studied	study	VBN
cord-023417-by18aczt	394	25	.	.	.
cord-023417-by18aczt	395	1	We	-PRON-	PRP
cord-023417-by18aczt	395	2	found	find	VBD
cord-023417-by18aczt	395	3	that	that	IN
cord-023417-by18aczt	395	4	the	the	DT
cord-023417-by18aczt	395	5	majority	majority	NN
cord-023417-by18aczt	395	6	of	of	IN
cord-023417-by18aczt	395	7	the	the	DT
cord-023417-by18aczt	395	8	CD1a	CD1a	NNP
cord-023417-by18aczt	395	9	þ	þ	NNP
cord-023417-by18aczt	395	10	MDDCs	mddc	NNS
cord-023417-by18aczt	395	11	were	be	VBD
cord-023417-by18aczt	395	12	capable	capable	JJ
cord-023417-by18aczt	395	13	of	of	IN
cord-023417-by18aczt	395	14	taking	take	VBG
cord-023417-by18aczt	395	15	up	up	RP
cord-023417-by18aczt	395	16	FITC	FITC	NNP
cord-023417-by18aczt	395	17	-	-	HYPH
cord-023417-by18aczt	395	18	labelled	label	VBN
cord-023417-by18aczt	395	19	CBP	CBP	NNP
cord-023417-by18aczt	395	20	-	-	HYPH
cord-023417-by18aczt	395	21	Fel	Fel	NNP
cord-023417-by18aczt	395	22	d	d	NN
cord-023417-by18aczt	395	23	1	1	CD
cord-023417-by18aczt	395	24	,	,	,
cord-023417-by18aczt	395	25	as	as	IN
cord-023417-by18aczt	395	26	demonstrated	demonstrate	VBN
cord-023417-by18aczt	395	27	by	by	IN
cord-023417-by18aczt	395	28	flow	flow	NN
cord-023417-by18aczt	395	29	cytometry	cytometry	NN
cord-023417-by18aczt	395	30	and	and	CC
cord-023417-by18aczt	395	31	confocal	confocal	JJ
cord-023417-by18aczt	395	32	laser	laser	NN
cord-023417-by18aczt	395	33	scanning	scanning	NN
cord-023417-by18aczt	395	34	microscopy	microscopy	NNS
cord-023417-by18aczt	395	35	.	.	.
cord-023417-by18aczt	396	1	Furthermore	furthermore	RB
cord-023417-by18aczt	396	2	,	,	,
cord-023417-by18aczt	396	3	incubation	incubation	NN
cord-023417-by18aczt	396	4	with	with	IN
cord-023417-by18aczt	396	5	CBP	CBP	NNP
cord-023417-by18aczt	396	6	-	-	HYPH
cord-023417-by18aczt	396	7	Fel	Fel	NNP
cord-023417-by18aczt	396	8	d	d	NNP
cord-023417-by18aczt	396	9	1	1	CD
cord-023417-by18aczt	396	10	resulted	result	VBD
cord-023417-by18aczt	396	11	in	in	IN
cord-023417-by18aczt	396	12	an	an	DT
cord-023417-by18aczt	396	13	upregulation	upregulation	NN
cord-023417-by18aczt	396	14	of	of	IN
cord-023417-by18aczt	396	15	the	the	DT
cord-023417-by18aczt	396	16	costimulatory	costimulatory	NN
cord-023417-by18aczt	396	17	molecule	molecule	NN
cord-023417-by18aczt	396	18	CD86	CD86	NNP
cord-023417-by18aczt	396	19	on	on	IN
cord-023417-by18aczt	396	20	the	the	DT
cord-023417-by18aczt	396	21	MDDCs	mddc	NNS
cord-023417-by18aczt	396	22	,	,	,
cord-023417-by18aczt	396	23	which	which	WDT
cord-023417-by18aczt	396	24	was	be	VBD
cord-023417-by18aczt	396	25	not	not	RB
cord-023417-by18aczt	396	26	observed	observe	VBN
cord-023417-by18aczt	396	27	with	with	IN
cord-023417-by18aczt	396	28	Fel	Fel	NNP
cord-023417-by18aczt	396	29	d	d	NNP
cord-023417-by18aczt	396	30	1	1	CD
cord-023417-by18aczt	396	31	or	or	CC
cord-023417-by18aczt	396	32	CBPs	cbps	NN
cord-023417-by18aczt	396	33	alone	alone	RB
cord-023417-by18aczt	396	34	.	.	.
cord-023417-by18aczt	397	1	Finally	finally	RB
cord-023417-by18aczt	397	2	,	,	,
cord-023417-by18aczt	397	3	CBP	CBP	NNP
cord-023417-by18aczt	397	4	-	-	HYPH
cord-023417-by18aczt	397	5	Fel	Fel	NNP
cord-023417-by18aczt	397	6	d	d	NNP
cord-023417-by18aczt	397	7	1	1	CD
cord-023417-by18aczt	397	8	induced	induce	VBD
cord-023417-by18aczt	397	9	a	a	DT
cord-023417-by18aczt	397	10	fivefold	fivefold	JJ
cord-023417-by18aczt	397	11	increase	increase	NN
cord-023417-by18aczt	397	12	in	in	IN
cord-023417-by18aczt	397	13	the	the	DT
cord-023417-by18aczt	397	14	release	release	NN
cord-023417-by18aczt	397	15	of	of	IN
cord-023417-by18aczt	397	16	the	the	DT
cord-023417-by18aczt	397	17	pro	pro	JJ
cord-023417-by18aczt	397	18	-	-	JJ
cord-023417-by18aczt	397	19	inflammatory	inflammatory	JJ
cord-023417-by18aczt	397	20	cytokine	cytokine	NN
cord-023417-by18aczt	397	21	tumour	tumour	NN
cord-023417-by18aczt	397	22	necrosis	necrosis	NN
cord-023417-by18aczt	397	23	factor	factor	NN
cord-023417-by18aczt	397	24	(	(	-LRB-
cord-023417-by18aczt	397	25	TNF)-a	TNF)-a	NNP
cord-023417-by18aczt	397	26	and	and	CC
cord-023417-by18aczt	397	27	a	a	DT
cord-023417-by18aczt	397	28	fourfold	fourfold	JJ
cord-023417-by18aczt	397	29	increase	increase	NN
cord-023417-by18aczt	397	30	in	in	IN
cord-023417-by18aczt	397	31	the	the	DT
cord-023417-by18aczt	397	32	release	release	NN
cord-023417-by18aczt	397	33	of	of	IN
cord-023417-by18aczt	397	34	the	the	DT
cord-023417-by18aczt	397	35	chemokine	chemokine	NN
cord-023417-by18aczt	397	36	interleukin-8	interleukin-8	NN
cord-023417-by18aczt	397	37	from	from	IN
cord-023417-by18aczt	397	38	MDDCs	mddc	NNS
cord-023417-by18aczt	397	39	.	.	.
cord-023417-by18aczt	398	1	Taken	take	VBN
cord-023417-by18aczt	398	2	together	together	RB
cord-023417-by18aczt	398	3	,	,	,
cord-023417-by18aczt	398	4	the	the	DT
cord-023417-by18aczt	398	5	effects	effect	NNS
cord-023417-by18aczt	398	6	CBPs	cbp	NNS
cord-023417-by18aczt	398	7	possess	possess	VBP
cord-023417-by18aczt	398	8	make	make	VB
cord-023417-by18aczt	398	9	them	-PRON-	PRP
cord-023417-by18aczt	398	10	interesting	interesting	JJ
cord-023417-by18aczt	398	11	as	as	IN
cord-023417-by18aczt	398	12	novel	novel	JJ
cord-023417-by18aczt	398	13	allergen	allergen	NN
cord-023417-by18aczt	398	14	carriers	carrier	NNS
cord-023417-by18aczt	398	15	for	for	IN
cord-023417-by18aczt	398	16	SIT	sit	NN
cord-023417-by18aczt	398	17	.	.	.
cord-023417-by18aczt	399	1	The	the	DT
cord-023417-by18aczt	399	2	cysteine	cysteine	NN
cord-023417-by18aczt	399	3	protease	protease	NN
cord-023417-by18aczt	399	4	Der	Der	NNP
cord-023417-by18aczt	399	5	p1	p1	NN
cord-023417-by18aczt	399	6	from	from	IN
cord-023417-by18aczt	399	7	dust	dust	NN
cord-023417-by18aczt	399	8	mite	mite	NN
cord-023417-by18aczt	399	9	of	of	IN
cord-023417-by18aczt	399	10	the	the	DT
cord-023417-by18aczt	399	11	genus	genus	NN
cord-023417-by18aczt	399	12	Dermatophagoides	Dermatophagoides	NNP
cord-023417-by18aczt	399	13	pteronyssinus	pteronyssinus	NNP
cord-023417-by18aczt	399	14	is	be	VBZ
cord-023417-by18aczt	399	15	a	a	DT
cord-023417-by18aczt	399	16	major	major	JJ
cord-023417-by18aczt	399	17	type	type	NN
cord-023417-by18aczt	399	18	I	-PRON-	PRP
cord-023417-by18aczt	399	19	allergen	allergen	NN
cord-023417-by18aczt	399	20	.	.	.
cord-023417-by18aczt	400	1	About	about	RB
cord-023417-by18aczt	400	2	80	80	CD
cord-023417-by18aczt	400	3	%	%	NN
cord-023417-by18aczt	400	4	of	of	IN
cord-023417-by18aczt	400	5	house	house	NN
cord-023417-by18aczt	400	6	dust	dust	NN
cord-023417-by18aczt	400	7	mite	mite	NNP
cord-023417-by18aczt	400	8	(	(	-LRB-
cord-023417-by18aczt	400	9	HDM	HDM	NNP
cord-023417-by18aczt	400	10	)	)	-RRB-
cord-023417-by18aczt	400	11	allergic	allergic	JJ
cord-023417-by18aczt	400	12	individuals	individual	NNS
cord-023417-by18aczt	400	13	are	be	VBP
cord-023417-by18aczt	400	14	reactive	reactive	JJ
cord-023417-by18aczt	400	15	to	to	IN
cord-023417-by18aczt	400	16	this	this	DT
cord-023417-by18aczt	400	17	protease	protease	NN
cord-023417-by18aczt	400	18	in	in	IN
cord-023417-by18aczt	400	19	standard	standard	JJ
cord-023417-by18aczt	400	20	assays	assay	NNS
cord-023417-by18aczt	400	21	for	for	IN
cord-023417-by18aczt	400	22	detection	detection	NN
cord-023417-by18aczt	400	23	of	of	IN
cord-023417-by18aczt	400	24	IgE.	ige.	NN
cord-023417-by18aczt	401	1	A	a	DT
cord-023417-by18aczt	401	2	curative	curative	JJ
cord-023417-by18aczt	401	3	treatment	treatment	NN
cord-023417-by18aczt	401	4	for	for	IN
cord-023417-by18aczt	401	5	atopic	atopic	JJ
cord-023417-by18aczt	401	6	allergy	allergy	NN
cord-023417-by18aczt	401	7	is	be	VBZ
cord-023417-by18aczt	401	8	immunotherapy	immunotherapy	NN
cord-023417-by18aczt	401	9	(	(	-LRB-
cord-023417-by18aczt	401	10	IT	it	NN
cord-023417-by18aczt	401	11	)	)	-RRB-
cord-023417-by18aczt	401	12	with	with	IN
cord-023417-by18aczt	401	13	HDM	HDM	NNP
cord-023417-by18aczt	401	14	extracts	extract	NNS
cord-023417-by18aczt	401	15	which	which	WDT
cord-023417-by18aczt	401	16	are	be	VBP
cord-023417-by18aczt	401	17	complex	complex	JJ
cord-023417-by18aczt	401	18	mixtures	mixture	NNS
cord-023417-by18aczt	401	19	occasionally	occasionally	RB
cord-023417-by18aczt	401	20	resulting	result	VBG
cord-023417-by18aczt	401	21	in	in	IN
cord-023417-by18aczt	401	22	anaphylactic	anaphylactic	JJ
cord-023417-by18aczt	401	23	reactions	reaction	NNS
cord-023417-by18aczt	401	24	.	.	.
cord-023417-by18aczt	402	1	Novozymes	Novozymes	NNP
cord-023417-by18aczt	402	2	focuses	focus	VBZ
cord-023417-by18aczt	402	3	on	on	IN
cord-023417-by18aczt	402	4	developing	develop	VBG
cord-023417-by18aczt	402	5	a	a	DT
cord-023417-by18aczt	402	6	recombinant	recombinant	JJ
cord-023417-by18aczt	402	7	variant	variant	NN
cord-023417-by18aczt	402	8	of	of	IN
cord-023417-by18aczt	402	9	Der	Der	NNP
cord-023417-by18aczt	402	10	p1	p1	NNP
cord-023417-by18aczt	402	11	which	which	WDT
cord-023417-by18aczt	402	12	exhibit	exhibit	VBP
cord-023417-by18aczt	402	13	lowered	lower	VBD
cord-023417-by18aczt	402	14	risk	risk	NN
cord-023417-by18aczt	402	15	of	of	IN
cord-023417-by18aczt	402	16	IgE	IgE	NNP
cord-023417-by18aczt	402	17	-	-	HYPH
cord-023417-by18aczt	402	18	mediated	mediate	VBN
cord-023417-by18aczt	402	19	allergic	allergic	JJ
cord-023417-by18aczt	402	20	reactions	reaction	NNS
cord-023417-by18aczt	402	21	,	,	,
cord-023417-by18aczt	402	22	while	while	IN
cord-023417-by18aczt	402	23	maintaining	maintain	VBG
cord-023417-by18aczt	402	24	its	-PRON-	PRP$
cord-023417-by18aczt	402	25	ability	ability	NN
cord-023417-by18aczt	402	26	to	to	TO
cord-023417-by18aczt	402	27	trigger	trigger	VB
cord-023417-by18aczt	402	28	proper	proper	JJ
cord-023417-by18aczt	402	29	Th	th	JJ
cord-023417-by18aczt	402	30	-	-	HYPH
cord-023417-by18aczt	402	31	cell	cell	NN
cord-023417-by18aczt	402	32	responses	response	NNS
cord-023417-by18aczt	402	33	.	.	.
cord-023417-by18aczt	403	1	This	this	DT
cord-023417-by18aczt	403	2	may	may	MD
cord-023417-by18aczt	403	3	provide	provide	VB
cord-023417-by18aczt	403	4	a	a	DT
cord-023417-by18aczt	403	5	safer	safe	JJR
cord-023417-by18aczt	403	6	alternative	alternative	NN
cord-023417-by18aczt	403	7	for	for	IN
cord-023417-by18aczt	403	8	specific	specific	JJ
cord-023417-by18aczt	403	9	IT	it	NN
cord-023417-by18aczt	403	10	of	of	IN
cord-023417-by18aczt	403	11	HDM	HDM	NNP
cord-023417-by18aczt	403	12	allergy	allergy	NN
cord-023417-by18aczt	403	13	.	.	.
cord-023417-by18aczt	404	1	A	a	DT
cord-023417-by18aczt	404	2	secreted	secrete	VBN
cord-023417-by18aczt	404	3	recombinant	recombinant	JJ
cord-023417-by18aczt	404	4	form	form	NN
cord-023417-by18aczt	404	5	of	of	IN
cord-023417-by18aczt	404	6	pro	pro	JJ
cord-023417-by18aczt	404	7	-	-	JJ
cord-023417-by18aczt	404	8	Der	der	JJ
cord-023417-by18aczt	404	9	p	p	NN
cord-023417-by18aczt	404	10	1	1	CD
cord-023417-by18aczt	404	11	expressed	express	VBN
cord-023417-by18aczt	404	12	by	by	IN
cord-023417-by18aczt	404	13	Saccharamyces	Saccharamyces	NNP
cord-023417-by18aczt	404	14	cerevisiae	cerevisiae	NNS
cord-023417-by18aczt	404	15	was	be	VBD
cord-023417-by18aczt	404	16	obtained	obtain	VBN
cord-023417-by18aczt	404	17	by	by	IN
cord-023417-by18aczt	404	18	fusion	fusion	NN
cord-023417-by18aczt	404	19	of	of	IN
cord-023417-by18aczt	404	20	the	the	DT
cord-023417-by18aczt	404	21	pro	pro	JJ
cord-023417-by18aczt	404	22	-	-	JJ
cord-023417-by18aczt	404	23	enzyme	enzyme	JJ
cord-023417-by18aczt	404	24	to	to	IN
cord-023417-by18aczt	404	25	a	a	DT
cord-023417-by18aczt	404	26	fungal	fungal	JJ
cord-023417-by18aczt	404	27	signal	signal	NN
cord-023417-by18aczt	404	28	peptide	peptide	NN
cord-023417-by18aczt	404	29	.	.	.
cord-023417-by18aczt	405	1	The	the	DT
cord-023417-by18aczt	405	2	N	n	CD
cord-023417-by18aczt	405	3	-	-	HYPH
cord-023417-by18aczt	405	4	glycosylation	glycosylation	NN
cord-023417-by18aczt	405	5	site	site	NN
cord-023417-by18aczt	405	6	of	of	IN
cord-023417-by18aczt	405	7	Der	Der	NNP
cord-023417-by18aczt	405	8	p1	p1	NNP
cord-023417-by18aczt	405	9	was	be	VBD
cord-023417-by18aczt	405	10	mutated	mutate	VBN
cord-023417-by18aczt	405	11	resulting	result	VBG
cord-023417-by18aczt	405	12	in	in	IN
cord-023417-by18aczt	405	13	a	a	DT
cord-023417-by18aczt	405	14	deglycosylated	deglycosylated	JJ
cord-023417-by18aczt	405	15	pro	pro	JJ
cord-023417-by18aczt	405	16	-	-	JJ
cord-023417-by18aczt	405	17	enzyme	enzyme	JJ
cord-023417-by18aczt	405	18	with	with	IN
cord-023417-by18aczt	405	19	a	a	DT
cord-023417-by18aczt	405	20	molecular	molecular	JJ
cord-023417-by18aczt	405	21	mass	mass	NN
cord-023417-by18aczt	405	22	of	of	IN
cord-023417-by18aczt	405	23	35	35	CD
cord-023417-by18aczt	405	24	kDa	kDa	NNS
cord-023417-by18aczt	405	25	.	.	.
cord-023417-by18aczt	406	1	Protein	protein	NN
cord-023417-by18aczt	406	2	purification	purification	NN
cord-023417-by18aczt	406	3	procedure	procedure	NN
cord-023417-by18aczt	406	4	was	be	VBD
cord-023417-by18aczt	406	5	developed	develop	VBN
cord-023417-by18aczt	406	6	to	to	TO
cord-023417-by18aczt	406	7	obtain	obtain	VB
cord-023417-by18aczt	406	8	nearly	nearly	RB
cord-023417-by18aczt	406	9	pure	pure	JJ
cord-023417-by18aczt	406	10	Der	Der	NNP
cord-023417-by18aczt	406	11	p1	p1	NNP
cord-023417-by18aczt	406	12	protein	protein	NN
cord-023417-by18aczt	406	13	followed	follow	VBN
cord-023417-by18aczt	406	14	by	by	IN
cord-023417-by18aczt	406	15	determination	determination	NN
cord-023417-by18aczt	406	16	of	of	IN
cord-023417-by18aczt	406	17	concentration	concentration	NN
cord-023417-by18aczt	406	18	by	by	IN
cord-023417-by18aczt	406	19	active	active	JJ
cord-023417-by18aczt	406	20	-	-	HYPH
cord-023417-by18aczt	406	21	site	site	NN
cord-023417-by18aczt	406	22	-	-	HYPH
cord-023417-by18aczt	406	23	titration	titration	NN
cord-023417-by18aczt	406	24	with	with	IN
cord-023417-by18aczt	406	25	the	the	DT
cord-023417-by18aczt	406	26	cysteine	cysteine	NN
cord-023417-by18aczt	406	27	protease	protease	NN
cord-023417-by18aczt	406	28	inhibitor	inhibitor	NN
cord-023417-by18aczt	406	29	E64	E64	NNP
cord-023417-by18aczt	406	30	.	.	.
cord-023417-by18aczt	407	1	The	the	DT
cord-023417-by18aczt	407	2	deglycosylated	deglycosylated	JJ
cord-023417-by18aczt	407	3	recombinant	recombinant	JJ
cord-023417-by18aczt	407	4	pro	pro	JJ
cord-023417-by18aczt	407	5	-	-	JJ
cord-023417-by18aczt	407	6	Der	der	JJ
cord-023417-by18aczt	407	7	p	p	NN
cord-023417-by18aczt	407	8	1	1	CD
cord-023417-by18aczt	407	9	revealed	reveal	VBD
cord-023417-by18aczt	407	10	immunologic	immunologic	JJ
cord-023417-by18aczt	407	11	similarity	similarity	NN
cord-023417-by18aczt	407	12	to	to	IN
cord-023417-by18aczt	407	13	the	the	DT
cord-023417-by18aczt	407	14	native	native	JJ
cord-023417-by18aczt	407	15	Der	Der	NNP
cord-023417-by18aczt	407	16	p	p	NN
cord-023417-by18aczt	407	17	1	1	CD
cord-023417-by18aczt	407	18	molecule	molecule	NN
cord-023417-by18aczt	407	19	when	when	WRB
cord-023417-by18aczt	407	20	compared	compare	VBN
cord-023417-by18aczt	407	21	in	in	IN
cord-023417-by18aczt	407	22	basophile	basophile	JJ
cord-023417-by18aczt	407	23	histamine	histamine	NN
cord-023417-by18aczt	407	24	release	release	NN
cord-023417-by18aczt	407	25	,	,	,
cord-023417-by18aczt	407	26	IgE	ige	NN
cord-023417-by18aczt	407	27	-	-	HYPH
cord-023417-by18aczt	407	28	binding	bind	VBG
cord-023417-by18aczt	407	29	assays	assay	NNS
cord-023417-by18aczt	407	30	and	and	CC
cord-023417-by18aczt	407	31	T	t	NN
cord-023417-by18aczt	407	32	-	-	HYPH
cord-023417-by18aczt	407	33	cell	cell	NN
cord-023417-by18aczt	407	34	proliferation	proliferation	NN
cord-023417-by18aczt	407	35	assays	assay	NNS
cord-023417-by18aczt	407	36	.	.	.
cord-023417-by18aczt	408	1	By	by	IN
cord-023417-by18aczt	408	2	in	in	IN
cord-023417-by18aczt	408	3	silico	silico	NN
cord-023417-by18aczt	408	4	epitope	epitope	NN
cord-023417-by18aczt	408	5	mapping	mapping	NN
cord-023417-by18aczt	408	6	of	of	IN
cord-023417-by18aczt	408	7	a	a	DT
cord-023417-by18aczt	408	8	modelled	model	VBN
cord-023417-by18aczt	408	9	3-dimensional	3-dimensional	JJ
cord-023417-by18aczt	408	10	structure	structure	NN
cord-023417-by18aczt	408	11	of	of	IN
cord-023417-by18aczt	408	12	Der	Der	NNP
cord-023417-by18aczt	408	13	p1	p1	NNP
cord-023417-by18aczt	408	14	,	,	,
cord-023417-by18aczt	408	15	five	five	CD
cord-023417-by18aczt	408	16	putative	putative	JJ
cord-023417-by18aczt	408	17	IgG	IgG	NNP
cord-023417-by18aczt	408	18	and	and	CC
cord-023417-by18aczt	408	19	IgE	IgE	NNP
cord-023417-by18aczt	408	20	epitopes	epitope	NNS
cord-023417-by18aczt	408	21	were	be	VBD
cord-023417-by18aczt	408	22	predicted	predict	VBN
cord-023417-by18aczt	408	23	.	.	.
cord-023417-by18aczt	409	1	By	by	IN
cord-023417-by18aczt	409	2	protein	protein	NN
cord-023417-by18aczt	409	3	engineering	engineering	NN
cord-023417-by18aczt	409	4	,	,	,
cord-023417-by18aczt	409	5	the	the	DT
cord-023417-by18aczt	409	6	predicted	predict	VBN
cord-023417-by18aczt	409	7	epitopes	epitope	NNS
cord-023417-by18aczt	409	8	were	be	VBD
cord-023417-by18aczt	409	9	removed	remove	VBN
cord-023417-by18aczt	409	10	one	one	CD
cord-023417-by18aczt	409	11	by	by	IN
cord-023417-by18aczt	409	12	one	one	CD
cord-023417-by18aczt	409	13	in	in	IN
cord-023417-by18aczt	409	14	Der	Der	NNP
cord-023417-by18aczt	409	15	p1	p1	NN
cord-023417-by18aczt	409	16	and	and	CC
cord-023417-by18aczt	409	17	screening	screening	NN
cord-023417-by18aczt	409	18	for	for	IN
cord-023417-by18aczt	409	19	hypoallergenic	hypoallergenic	JJ
cord-023417-by18aczt	409	20	variants	variant	NNS
cord-023417-by18aczt	409	21	was	be	VBD
cord-023417-by18aczt	409	22	performed	perform	VBN
cord-023417-by18aczt	409	23	.	.	.
cord-023417-by18aczt	410	1	Combining	combine	VBG
cord-023417-by18aczt	410	2	inhaled	inhale	VBN
cord-023417-by18aczt	410	3	long	long	RB
cord-023417-by18aczt	410	4	-	-	HYPH
cord-023417-by18aczt	410	5	acting	act	VBG
cord-023417-by18aczt	410	6	b-2	b-2	NN
cord-023417-by18aczt	410	7	agonist	agonist	NN
cord-023417-by18aczt	410	8	(	(	-LRB-
cord-023417-by18aczt	410	9	LABA	LABA	NNP
cord-023417-by18aczt	410	10	)	)	-RRB-
cord-023417-by18aczt	410	11	and	and	CC
cord-023417-by18aczt	410	12	inhaled	inhale	VBN
cord-023417-by18aczt	410	13	corticosteroid	corticosteroid	NNP
cord-023417-by18aczt	410	14	(	(	-LRB-
cord-023417-by18aczt	410	15	ICS	ICS	NNP
cord-023417-by18aczt	410	16	)	)	-RRB-
cord-023417-by18aczt	410	17	seems	seem	VBZ
cord-023417-by18aczt	410	18	to	to	TO
cord-023417-by18aczt	410	19	offer	offer	VB
cord-023417-by18aczt	410	20	asthma	asthma	NN
cord-023417-by18aczt	410	21	control	control	NN
cord-023417-by18aczt	410	22	at	at	IN
cord-023417-by18aczt	410	23	a	a	DT
cord-023417-by18aczt	410	24	lower	low	JJR
cord-023417-by18aczt	410	25	dose	dose	NN
cord-023417-by18aczt	410	26	of	of	IN
cord-023417-by18aczt	410	27	ICS	ICS	NNP
cord-023417-by18aczt	410	28	than	than	IN
cord-023417-by18aczt	410	29	achieved	achieve	VBN
cord-023417-by18aczt	410	30	by	by	IN
cord-023417-by18aczt	410	31	ICS	ICS	NNP
cord-023417-by18aczt	410	32	alone	alone	JJ
cord-023417-by18aczt	410	33	.	.	.
cord-023417-by18aczt	411	1	Fine	fine	JJ
cord-023417-by18aczt	411	2	mapping	mapping	NN
cord-023417-by18aczt	411	3	of	of	IN
cord-023417-by18aczt	411	4	T	t	NN
cord-023417-by18aczt	411	5	-	-	HYPH
cord-023417-by18aczt	411	6	cell	cell	NN
cord-023417-by18aczt	411	7	surface	surface	NN
cord-023417-by18aczt	411	8	markers	marker	NNS
cord-023417-by18aczt	411	9	by	by	IN
cord-023417-by18aczt	411	10	flow	flow	NN
cord-023417-by18aczt	411	11	cytometry	cytometry	NN
cord-023417-by18aczt	411	12	offers	offer	VBZ
cord-023417-by18aczt	411	13	a	a	DT
cord-023417-by18aczt	411	14	detailed	detailed	JJ
cord-023417-by18aczt	411	15	status	status	NN
cord-023417-by18aczt	411	16	of	of	IN
cord-023417-by18aczt	411	17	the	the	DT
cord-023417-by18aczt	411	18	individual	individual	NN
cord-023417-by18aczt	411	19	's	's	POS
cord-023417-by18aczt	411	20	inflammatory	inflammatory	JJ
cord-023417-by18aczt	411	21	response	response	NN
cord-023417-by18aczt	411	22	.	.	.
cord-023417-by18aczt	412	1	The	the	DT
cord-023417-by18aczt	412	2	frequency	frequency	NN
cord-023417-by18aczt	412	3	of	of	IN
cord-023417-by18aczt	412	4	MT2	mt2	NN
cord-023417-by18aczt	412	5	(	(	-LRB-
cord-023417-by18aczt	412	6	CD4	CD4	NNP
cord-023417-by18aczt	412	7	þ	þ	NNP
cord-023417-by18aczt	412	8	CD45RA	cd45ra	NN
cord-023417-by18aczt	412	9	-CD62L	-CD62L	NNP
cord-023417-by18aczt	412	10	þ	þ	CD
cord-023417-by18aczt	412	11	CD11adim	CD11adim	NNPS
cord-023417-by18aczt	412	12	)	)	-RRB-
cord-023417-by18aczt	412	13	and	and	CC
cord-023417-by18aczt	412	14	MT1	MT1	NNP
cord-023417-by18aczt	412	15	(	(	-LRB-
cord-023417-by18aczt	412	16	CD4	CD4	NNP
cord-023417-by18aczt	412	17	þ	þ	NNP
cord-023417-by18aczt	412	18	CD45RA	cd45ra	NN
cord-023417-by18aczt	412	19	-CD62L	-CD62L	NNP
cord-023417-by18aczt	412	20	-CD11abright	-CD11abright	NFP
cord-023417-by18aczt	412	21	)	)	-RRB-
cord-023417-by18aczt	412	22	cells	cell	NNS
cord-023417-by18aczt	412	23	in	in	IN
cord-023417-by18aczt	412	24	peripheral	peripheral	JJ
cord-023417-by18aczt	412	25	blood	blood	NN
cord-023417-by18aczt	412	26	,	,	,
cord-023417-by18aczt	412	27	and	and	CC
cord-023417-by18aczt	412	28	their	-PRON-	PRP$
cord-023417-by18aczt	412	29	ratio	ratio	NN
cord-023417-by18aczt	412	30	,	,	,
cord-023417-by18aczt	412	31	has	have	VBZ
cord-023417-by18aczt	412	32	been	be	VBN
cord-023417-by18aczt	412	33	shown	show	VBN
cord-023417-by18aczt	412	34	to	to	TO
cord-023417-by18aczt	412	35	differ	differ	VB
cord-023417-by18aczt	412	36	predictably	predictably	RB
cord-023417-by18aczt	412	37	in	in	IN
cord-023417-by18aczt	412	38	atopics	atopic	NNS
cord-023417-by18aczt	412	39	and	and	CC
cord-023417-by18aczt	412	40	patients	patient	NNS
cord-023417-by18aczt	412	41	with	with	IN
cord-023417-by18aczt	412	42	leprosy	leprosy	NN
cord-023417-by18aczt	412	43	,	,	,
cord-023417-by18aczt	412	44	where	where	WRB
cord-023417-by18aczt	412	45	MT2	MT2	NNP
cord-023417-by18aczt	412	46	correlates	correlate	VBZ
cord-023417-by18aczt	412	47	with	with	IN
cord-023417-by18aczt	412	48	a	a	DT
cord-023417-by18aczt	412	49	Th2	th2	CD
cord-023417-by18aczt	412	50	phenotype	phenotype	NN
cord-023417-by18aczt	412	51	and	and	CC
cord-023417-by18aczt	412	52	MT1	MT1	NNP
cord-023417-by18aczt	412	53	with	with	IN
cord-023417-by18aczt	412	54	a	a	DT
cord-023417-by18aczt	412	55	Th1	th1	CD
cord-023417-by18aczt	412	56	phenotype	phenotype	NN
cord-023417-by18aczt	412	57	.	.	.
cord-023417-by18aczt	413	1	Stable	stable	JJ
cord-023417-by18aczt	413	2	asthmatics	asthmatic	NNS
cord-023417-by18aczt	413	3	,	,	,
cord-023417-by18aczt	413	4	requiring	require	VBG
cord-023417-by18aczt	413	5	fluticasone	fluticasone	NN
cord-023417-by18aczt	413	6	propionate	propionate	NN
cord-023417-by18aczt	413	7	(	(	-LRB-
cord-023417-by18aczt	413	8	FP	FP	NNP
cord-023417-by18aczt	413	9	)	)	-RRB-
cord-023417-by18aczt	413	10	750	750	CD
cord-023417-by18aczt	413	11	-	-	HYPH
cord-023417-by18aczt	413	12	1000	1000	CD
cord-023417-by18aczt	413	13	mg	mg	NNP
cord-023417-by18aczt	413	14	daily	daily	JJ
cord-023417-by18aczt	413	15	or	or	CC
cord-023417-by18aczt	413	16	equivalent	equivalent	JJ
cord-023417-by18aczt	413	17	,	,	,
cord-023417-by18aczt	413	18	were	be	VBD
cord-023417-by18aczt	413	19	randomized	randomize	VBN
cord-023417-by18aczt	413	20	to	to	TO
cord-023417-by18aczt	413	21	receive	receive	VB
cord-023417-by18aczt	413	22	,	,	,
cord-023417-by18aczt	413	23	double	double	JJ
cord-023417-by18aczt	413	24	-	-	HYPH
cord-023417-by18aczt	413	25	blinded	blinded	JJ
cord-023417-by18aczt	413	26	,	,	,
cord-023417-by18aczt	414	1	either	either	CC
cord-023417-by18aczt	414	2	Seretide	Seretide	NNP
cord-023417-by18aczt	414	3	1	1	CD
cord-023417-by18aczt	414	4	[	[	-LRB-
cord-023417-by18aczt	414	5	salmeterol	salmeterol	NN
cord-023417-by18aczt	414	6	and	and	CC
cord-023417-by18aczt	414	7	fluticasone	fluticasone	NN
cord-023417-by18aczt	414	8	propionate	propionate	NNP
cord-023417-by18aczt	414	9	(	(	-LRB-
cord-023417-by18aczt	414	10	SFC	SFC	NNP
cord-023417-by18aczt	414	11	,	,	,
cord-023417-by18aczt	414	12	n	n	NN
cord-023417-by18aczt	414	13	¼	¼	NNP
cord-023417-by18aczt	414	14	16	16	CD
cord-023417-by18aczt	414	15	)	)	-RRB-
cord-023417-by18aczt	414	16	]	]	-RRB-
cord-023417-by18aczt	415	1	50	50	CD
cord-023417-by18aczt	415	2	mg/500	mg/500	NNS
cord-023417-by18aczt	415	3	mg	mg	NNP
cord-023417-by18aczt	415	4	bd	bd	NNP
cord-023417-by18aczt	415	5	or	or	CC
cord-023417-by18aczt	415	6	FP	FP	NNP
cord-023417-by18aczt	416	1	500	500	CD
cord-023417-by18aczt	416	2	mg	mg	NNP
cord-023417-by18aczt	416	3	bd	bd	NNP
cord-023417-by18aczt	416	4	(	(	-LRB-
cord-023417-by18aczt	416	5	n	n	NNP
cord-023417-by18aczt	416	6	¼	¼	NNP
cord-023417-by18aczt	416	7	17	17	CD
cord-023417-by18aczt	416	8	)	)	-RRB-
cord-023417-by18aczt	416	9	.	.	.
cord-023417-by18aczt	417	1	If	if	IN
cord-023417-by18aczt	417	2	asthma	asthma	NN
cord-023417-by18aczt	417	3	was	be	VBD
cord-023417-by18aczt	417	4	controlled	control	VBN
cord-023417-by18aczt	417	5	based	base	VBN
cord-023417-by18aczt	417	6	on	on	IN
cord-023417-by18aczt	417	7	lung	lung	NN
cord-023417-by18aczt	417	8	function	function	NN
cord-023417-by18aczt	417	9	and	and	CC
cord-023417-by18aczt	417	10	symptoms	symptom	NNS
cord-023417-by18aczt	417	11	at	at	IN
cord-023417-by18aczt	417	12	clinic	clinic	NN
cord-023417-by18aczt	417	13	visits	visit	VBZ
cord-023417-by18aczt	417	14	every	every	DT
cord-023417-by18aczt	417	15	6	6	CD
cord-023417-by18aczt	417	16	weeks	week	NNS
cord-023417-by18aczt	417	17	,	,	,
cord-023417-by18aczt	417	18	ICS	ICS	NNP
cord-023417-by18aczt	417	19	dose	dose	NN
cord-023417-by18aczt	417	20	was	be	VBD
cord-023417-by18aczt	417	21	tapered	taper	VBN
cord-023417-by18aczt	417	22	until	until	IN
cord-023417-by18aczt	417	23	asthma	asthma	NN
cord-023417-by18aczt	417	24	exacerbated	exacerbate	VBD
cord-023417-by18aczt	417	25	or	or	CC
cord-023417-by18aczt	417	26	0	0	NFP
cord-023417-by18aczt	417	27	mg	mg	NN
cord-023417-by18aczt	417	28	was	be	VBD
cord-023417-by18aczt	417	29	reached	reach	VBN
cord-023417-by18aczt	417	30	.	.	.
cord-023417-by18aczt	418	1	The	the	DT
cord-023417-by18aczt	418	2	frequency	frequency	NN
cord-023417-by18aczt	418	3	and	and	CC
cord-023417-by18aczt	418	4	ratio	ratio	NN
cord-023417-by18aczt	418	5	of	of	IN
cord-023417-by18aczt	418	6	MT2	MT2	NNP
cord-023417-by18aczt	418	7	and	and	CC
cord-023417-by18aczt	418	8	MT1	MT1	NNP
cord-023417-by18aczt	418	9	T	T	NNP
cord-023417-by18aczt	418	10	cells	cell	NNS
cord-023417-by18aczt	418	11	of	of	IN
cord-023417-by18aczt	418	12	the	the	DT
cord-023417-by18aczt	418	13	patients	patient	NNS
cord-023417-by18aczt	418	14	was	be	VBD
cord-023417-by18aczt	418	15	monitored	monitor	VBN
cord-023417-by18aczt	418	16	at	at	IN
cord-023417-by18aczt	418	17	6	6	CD
cord-023417-by18aczt	418	18	week	week	NN
cord-023417-by18aczt	418	19	intervals	interval	NNS
cord-023417-by18aczt	418	20	.	.	.
cord-023417-by18aczt	419	1	As	as	IN
cord-023417-by18aczt	419	2	treatment	treatment	NN
cord-023417-by18aczt	419	3	tapered	taper	VBN
cord-023417-by18aczt	419	4	,	,	,
cord-023417-by18aczt	419	5	the	the	DT
cord-023417-by18aczt	419	6	frequency	frequency	NN
cord-023417-by18aczt	419	7	of	of	IN
cord-023417-by18aczt	419	8	MT2	mt2	NN
cord-023417-by18aczt	419	9	cells	cell	NNS
cord-023417-by18aczt	419	10	decreased	decrease	VBD
cord-023417-by18aczt	419	11	(	(	-LRB-
cord-023417-by18aczt	419	12	P	p	NN
cord-023417-by18aczt	419	13	¼	¼	CD
cord-023417-by18aczt	419	14	0038	0038	CD
cord-023417-by18aczt	419	15	from	from	IN
cord-023417-by18aczt	419	16	first	first	JJ
cord-023417-by18aczt	419	17	to	to	IN
cord-023417-by18aczt	419	18	final	final	JJ
cord-023417-by18aczt	419	19	visit	visit	NN
cord-023417-by18aczt	419	20	)	)	-RRB-
cord-023417-by18aczt	419	21	,	,	,
cord-023417-by18aczt	419	22	whereas	whereas	IN
cord-023417-by18aczt	419	23	that	that	DT
cord-023417-by18aczt	419	24	of	of	IN
cord-023417-by18aczt	419	25	MT1	MT1	NNP
cord-023417-by18aczt	419	26	cells	cell	NNS
cord-023417-by18aczt	419	27	increased	increase	VBD
cord-023417-by18aczt	419	28	.	.	.
cord-023417-by18aczt	420	1	The	the	DT
cord-023417-by18aczt	420	2	ratio	ratio	NN
cord-023417-by18aczt	420	3	of	of	IN
cord-023417-by18aczt	420	4	MT2	MT2	NNP
cord-023417-by18aczt	420	5	/	/	SYM
cord-023417-by18aczt	420	6	MT1	MT1	NNP
cord-023417-by18aczt	420	7	decreased	decrease	VBD
cord-023417-by18aczt	420	8	(	(	-LRB-
cord-023417-by18aczt	420	9	P	p	NN
cord-023417-by18aczt	420	10	¼	¼	CD
cord-023417-by18aczt	420	11	0049	0049	CD
cord-023417-by18aczt	420	12	from	from	IN
cord-023417-by18aczt	420	13	first	first	JJ
cord-023417-by18aczt	420	14	to	to	IN
cord-023417-by18aczt	420	15	final	final	JJ
cord-023417-by18aczt	420	16	visit	visit	NN
cord-023417-by18aczt	420	17	)	)	-RRB-
cord-023417-by18aczt	420	18	.	.	.
cord-023417-by18aczt	421	1	In	in	IN
cord-023417-by18aczt	421	2	patients	patient	NNS
cord-023417-by18aczt	421	3	receiving	receive	VBG
cord-023417-by18aczt	421	4	LABA	LABA	NNP
cord-023417-by18aczt	421	5	þ	þ	NNP
cord-023417-by18aczt	421	6	ICS	ICS	NNP
cord-023417-by18aczt	421	7	,	,	,
cord-023417-by18aczt	421	8	the	the	DT
cord-023417-by18aczt	421	9	fall	fall	NN
cord-023417-by18aczt	421	10	in	in	IN
cord-023417-by18aczt	421	11	MT2	MT2	NNP
cord-023417-by18aczt	421	12	/	/	SYM
cord-023417-by18aczt	421	13	MT1	MT1	NNP
cord-023417-by18aczt	421	14	ratio	ratio	NN
cord-023417-by18aczt	421	15	appeared	appear	VBD
cord-023417-by18aczt	421	16	to	to	TO
cord-023417-by18aczt	421	17	be	be	VB
cord-023417-by18aczt	421	18	more	more	RBR
cord-023417-by18aczt	421	19	pronounced	pronounced	JJ
cord-023417-by18aczt	421	20	than	than	IN
cord-023417-by18aczt	421	21	in	in	IN
cord-023417-by18aczt	421	22	patients	patient	NNS
cord-023417-by18aczt	421	23	receiving	receive	VBG
cord-023417-by18aczt	421	24	ICS	ICS	NNP
cord-023417-by18aczt	421	25	alone	alone	JJ
cord-023417-by18aczt	421	26	.	.	.
cord-023417-by18aczt	422	1	Thus	thus	RB
cord-023417-by18aczt	422	2	,	,	,
cord-023417-by18aczt	422	3	the	the	DT
cord-023417-by18aczt	422	4	MT2	mt2	NN
cord-023417-by18aczt	422	5	phenotype	phenotype	NN
cord-023417-by18aczt	422	6	may	may	MD
cord-023417-by18aczt	422	7	be	be	VB
cord-023417-by18aczt	422	8	associated	associate	VBN
cord-023417-by18aczt	422	9	with	with	IN
cord-023417-by18aczt	422	10	stable	stable	JJ
cord-023417-by18aczt	422	11	asthma	asthma	NN
cord-023417-by18aczt	422	12	,	,	,
cord-023417-by18aczt	422	13	whereas	whereas	IN
cord-023417-by18aczt	422	14	an	an	DT
cord-023417-by18aczt	422	15	imminent	imminent	JJ
cord-023417-by18aczt	422	16	exacerbation	exacerbation	NN
cord-023417-by18aczt	422	17	may	may	MD
cord-023417-by18aczt	422	18	associate	associate	VB
cord-023417-by18aczt	422	19	with	with	IN
cord-023417-by18aczt	422	20	an	an	DT
cord-023417-by18aczt	422	21	increase	increase	NN
cord-023417-by18aczt	422	22	in	in	IN
cord-023417-by18aczt	422	23	the	the	DT
cord-023417-by18aczt	422	24	MT1	MT1	NNP
cord-023417-by18aczt	422	25	phenotype	phenotype	NN
cord-023417-by18aczt	422	26	.	.	.
cord-023417-by18aczt	423	1	LABA	LABA	NNP
cord-023417-by18aczt	423	2	may	may	MD
cord-023417-by18aczt	423	3	allow	allow	VB
cord-023417-by18aczt	423	4	for	for	IN
cord-023417-by18aczt	423	5	a	a	DT
cord-023417-by18aczt	423	6	greater	great	JJR
cord-023417-by18aczt	423	7	effect	effect	NN
cord-023417-by18aczt	423	8	of	of	IN
cord-023417-by18aczt	423	9	FP	FP	NNP
cord-023417-by18aczt	423	10	on	on	IN
cord-023417-by18aczt	423	11	the	the	DT
cord-023417-by18aczt	423	12	MT	MT	NNP
cord-023417-by18aczt	423	13	ratio	ratio	NN
cord-023417-by18aczt	423	14	.	.	.
cord-023417-by18aczt	424	1	Activation	activation	NN
cord-023417-by18aczt	424	2	of	of	IN
cord-023417-by18aczt	424	3	complement	complement	JJ
cord-023417-by18aczt	424	4	pathways	pathway	NNS
cord-023417-by18aczt	424	5	,	,	,
cord-023417-by18aczt	424	6	leading	lead	VBG
cord-023417-by18aczt	424	7	to	to	IN
cord-023417-by18aczt	424	8	production	production	NN
cord-023417-by18aczt	424	9	of	of	IN
cord-023417-by18aczt	424	10	C3a	C3a	NNP
cord-023417-by18aczt	424	11	and	and	CC
cord-023417-by18aczt	424	12	C5a	C5a	NNP
cord-023417-by18aczt	424	13	anaphylatoxins	anaphylatoxin	NNS
cord-023417-by18aczt	424	14	,	,	,
cord-023417-by18aczt	424	15	has	have	VBZ
cord-023417-by18aczt	424	16	been	be	VBN
cord-023417-by18aczt	424	17	postulated	postulate	VBN
cord-023417-by18aczt	424	18	in	in	IN
cord-023417-by18aczt	424	19	the	the	DT
cord-023417-by18aczt	424	20	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	424	21	of	of	IN
cord-023417-by18aczt	424	22	asthma	asthma	NN
cord-023417-by18aczt	424	23	and	and	CC
cord-023417-by18aczt	424	24	allergic	allergic	JJ
cord-023417-by18aczt	424	25	airway	airway	NN
cord-023417-by18aczt	424	26	inflammation	inflammation	NN
cord-023417-by18aczt	424	27	.	.	.
cord-023417-by18aczt	425	1	The	the	DT
cord-023417-by18aczt	425	2	present	present	JJ
cord-023417-by18aczt	425	3	study	study	NN
cord-023417-by18aczt	425	4	was	be	VBD
cord-023417-by18aczt	425	5	undertaken	undertake	VBN
cord-023417-by18aczt	425	6	to	to	TO
cord-023417-by18aczt	425	7	investigate	investigate	VB
cord-023417-by18aczt	425	8	the	the	DT
cord-023417-by18aczt	425	9	role	role	NN
cord-023417-by18aczt	425	10	of	of	IN
cord-023417-by18aczt	425	11	mannan	mannan	NNP
cord-023417-by18aczt	425	12	-	-	HYPH
cord-023417-by18aczt	425	13	binding	bind	VBG
cord-023417-by18aczt	425	14	lectin	lectin	NN
cord-023417-by18aczt	425	15	(	(	-LRB-
cord-023417-by18aczt	425	16	MBL	MBL	NNP
cord-023417-by18aczt	425	17	)	)	-RRB-
cord-023417-by18aczt	425	18	,	,	,
cord-023417-by18aczt	425	19	an	an	DT
cord-023417-by18aczt	425	20	initiator	initiator	NN
cord-023417-by18aczt	425	21	of	of	IN
cord-023417-by18aczt	425	22	the	the	DT
cord-023417-by18aczt	425	23	lectin	lectin	NN
cord-023417-by18aczt	425	24	pathway	pathway	NN
cord-023417-by18aczt	425	25	of	of	IN
cord-023417-by18aczt	425	26	complement	complement	NN
cord-023417-by18aczt	425	27	,	,	,
cord-023417-by18aczt	425	28	in	in	IN
cord-023417-by18aczt	425	29	asthma	asthma	NN
cord-023417-by18aczt	425	30	and	and	CC
cord-023417-by18aczt	425	31	allergic	allergic	JJ
cord-023417-by18aczt	425	32	rhinitis	rhinitis	NN
cord-023417-by18aczt	425	33	.	.	.
cord-023417-by18aczt	426	1	MBL	MBL	NNP
cord-023417-by18aczt	426	2	levels	level	NNS
cord-023417-by18aczt	426	3	and	and	CC
cord-023417-by18aczt	426	4	MBL	mbl	NN
cord-023417-by18aczt	426	5	-	-	HYPH
cord-023417-by18aczt	426	6	induced	induce	VBN
cord-023417-by18aczt	426	7	complement	complement	NN
cord-023417-by18aczt	426	8	activity	activity	NN
cord-023417-by18aczt	426	9	were	be	VBD
cord-023417-by18aczt	426	10	determined	determine	VBN
cord-023417-by18aczt	426	11	in	in	IN
cord-023417-by18aczt	426	12	19	19	CD
cord-023417-by18aczt	426	13	patients	patient	NNS
cord-023417-by18aczt	426	14	of	of	IN
cord-023417-by18aczt	426	15	bronchial	bronchial	JJ
cord-023417-by18aczt	426	16	asthma	asthma	NN
cord-023417-by18aczt	426	17	with	with	IN
cord-023417-by18aczt	426	18	allergic	allergic	JJ
cord-023417-by18aczt	426	19	rhinitis	rhinitis	NN
cord-023417-by18aczt	426	20	and	and	CC
cord-023417-by18aczt	426	21	20	20	CD
cord-023417-by18aczt	426	22	unrelated	unrelated	JJ
cord-023417-by18aczt	426	23	,	,	,
cord-023417-by18aczt	426	24	age	age	NN
cord-023417-by18aczt	426	25	-	-	HYPH
cord-023417-by18aczt	426	26	matched	match	VBN
cord-023417-by18aczt	426	27	controls	control	NNS
cord-023417-by18aczt	426	28	of	of	IN
cord-023417-by18aczt	426	29	Indian	indian	JJ
cord-023417-by18aczt	426	30	origin	origin	NN
cord-023417-by18aczt	426	31	.	.	.
cord-023417-by18aczt	427	1	MBL	MBL	NNP
cord-023417-by18aczt	427	2	levels	level	NNS
cord-023417-by18aczt	427	3	and	and	CC
cord-023417-by18aczt	427	4	activity	activity	NN
cord-023417-by18aczt	427	5	were	be	VBD
cord-023417-by18aczt	427	6	correlated	correlate	VBN
cord-023417-by18aczt	427	7	with	with	IN
cord-023417-by18aczt	427	8	percent	percent	NN
cord-023417-by18aczt	427	9	eosinophilia	eosinophilia	NN
cord-023417-by18aczt	427	10	and	and	CC
cord-023417-by18aczt	427	11	percent	percent	NN
cord-023417-by18aczt	427	12	predicted	predict	VBD
cord-023417-by18aczt	427	13	FEV1	FEV1	NNP
cord-023417-by18aczt	427	14	values	value	NNS
cord-023417-by18aczt	427	15	of	of	IN
cord-023417-by18aczt	427	16	the	the	DT
cord-023417-by18aczt	427	17	patients	patient	NNS
cord-023417-by18aczt	427	18	.	.	.
cord-023417-by18aczt	428	1	Association	Association	NNP
cord-023417-by18aczt	428	2	of	of	IN
cord-023417-by18aczt	428	3	single	single	JJ
cord-023417-by18aczt	428	4	nucleotide	nucleotide	JJ
cord-023417-by18aczt	428	5	polymorphisms	polymorphism	NNS
cord-023417-by18aczt	428	6	(	(	-LRB-
cord-023417-by18aczt	428	7	SNPs	SNPs	NNP
cord-023417-by18aczt	428	8	)	)	-RRB-
cord-023417-by18aczt	428	9	in	in	IN
cord-023417-by18aczt	428	10	exon	exon	NN
cord-023417-by18aczt	428	11	1	1	CD
cord-023417-by18aczt	428	12	and	and	CC
cord-023417-by18aczt	428	13	intron	intron	NN
cord-023417-by18aczt	428	14	1	1	CD
cord-023417-by18aczt	428	15	of	of	IN
cord-023417-by18aczt	428	16	the	the	DT
cord-023417-by18aczt	428	17	MBL	MBL	NNP
cord-023417-by18aczt	428	18	with	with	IN
cord-023417-by18aczt	428	19	the	the	DT
cord-023417-by18aczt	428	20	disease	disease	NN
cord-023417-by18aczt	428	21	,	,	,
cord-023417-by18aczt	428	22	clinical	clinical	JJ
cord-023417-by18aczt	428	23	markers	marker	NNS
cord-023417-by18aczt	428	24	,	,	,
cord-023417-by18aczt	428	25	MBL	MBL	NNP
cord-023417-by18aczt	428	26	levels	level	NNS
cord-023417-by18aczt	428	27	and	and	CC
cord-023417-by18aczt	428	28	MBL	mbl	NN
cord-023417-by18aczt	428	29	-	-	HYPH
cord-023417-by18aczt	428	30	induced	induce	VBN
cord-023417-by18aczt	428	31	complement	complement	NN
cord-023417-by18aczt	428	32	activity	activity	NN
cord-023417-by18aczt	428	33	was	be	VBD
cord-023417-by18aczt	428	34	analysed	analyse	VBN
cord-023417-by18aczt	428	35	using	use	VBG
cord-023417-by18aczt	428	36	standard	standard	JJ
cord-023417-by18aczt	428	37	statistical	statistical	JJ
cord-023417-by18aczt	428	38	tools	tool	NNS
cord-023417-by18aczt	428	39	.	.	.
cord-023417-by18aczt	429	1	Significantly	significantly	RB
cord-023417-by18aczt	429	2	higher	high	JJR
cord-023417-by18aczt	429	3	MBL	MBL	NNP
cord-023417-by18aczt	429	4	levels	level	NNS
cord-023417-by18aczt	429	5	and	and	CC
cord-023417-by18aczt	429	6	activity	activity	NN
cord-023417-by18aczt	429	7	were	be	VBD
cord-023417-by18aczt	429	8	observed	observe	VBN
cord-023417-by18aczt	429	9	in	in	IN
cord-023417-by18aczt	429	10	patients	patient	NNS
cord-023417-by18aczt	429	11	of	of	IN
cord-023417-by18aczt	429	12	bronchial	bronchial	JJ
cord-023417-by18aczt	429	13	asthma	asthma	NN
cord-023417-by18aczt	429	14	with	with	IN
cord-023417-by18aczt	429	15	allergic	allergic	JJ
cord-023417-by18aczt	429	16	rhinitis	rhinitis	NN
cord-023417-by18aczt	429	17	as	as	IN
cord-023417-by18aczt	429	18	compared	compare	VBN
cord-023417-by18aczt	429	19	to	to	IN
cord-023417-by18aczt	429	20	the	the	DT
cord-023417-by18aczt	429	21	controls	control	NNS
cord-023417-by18aczt	429	22	.	.	.
cord-023417-by18aczt	430	1	We	-PRON-	PRP
cord-023417-by18aczt	430	2	identified	identify	VBD
cord-023417-by18aczt	430	3	five	five	CD
cord-023417-by18aczt	430	4	SNPs	snp	NNS
cord-023417-by18aczt	430	5	,	,	,
cord-023417-by18aczt	430	6	of	of	IN
cord-023417-by18aczt	430	7	which	which	WDT
cord-023417-by18aczt	430	8	two	two	CD
cord-023417-by18aczt	430	9	,	,	,
cord-023417-by18aczt	430	10	A816	a816	NN
cord-023417-by18aczt	430	11	G	g	NN
cord-023417-by18aczt	430	12	in	in	IN
cord-023417-by18aczt	430	13	exon	exon	NN
cord-023417-by18aczt	430	14	1	1	CD
cord-023417-by18aczt	430	15	and	and	CC
cord-023417-by18aczt	430	16	G1011A	G1011A	NNP
cord-023417-by18aczt	430	17	in	in	IN
cord-023417-by18aczt	430	18	intron	intron	NN
cord-023417-by18aczt	430	19	1	1	CD
cord-023417-by18aczt	430	20	of	of	IN
cord-023417-by18aczt	430	21	the	the	DT
cord-023417-by18aczt	430	22	MBL	MBL	NNP
cord-023417-by18aczt	430	23	,	,	,
cord-023417-by18aczt	430	24	were	be	VBD
cord-023417-by18aczt	430	25	novel	novel	JJ
cord-023417-by18aczt	430	26	.	.	.
cord-023417-by18aczt	431	1	SNP	SNP	NNP
cord-023417-by18aczt	431	2	G1011A	G1011A	NNP
cord-023417-by18aczt	431	3	was	be	VBD
cord-023417-by18aczt	431	4	significantly	significantly	RB
cord-023417-by18aczt	431	5	associated	associate	VBN
cord-023417-by18aczt	431	6	with	with	IN
cord-023417-by18aczt	431	7	the	the	DT
cord-023417-by18aczt	431	8	disease	disease	NN
cord-023417-by18aczt	431	9	(	(	-LRB-
cord-023417-by18aczt	431	10	P	p	NN
cord-023417-by18aczt	431	11	¼	¼	NNP
cord-023417-by18aczt	431	12	0.0024	0.0024	CD
cord-023417-by18aczt	431	13	,	,	,
cord-023417-by18aczt	431	14	OR	or	CC
cord-023417-by18aczt	431	15	¼	¼	CD
cord-023417-by18aczt	431	16	5.8696	5.8696	CD
cord-023417-by18aczt	431	17	,	,	,
cord-023417-by18aczt	431	18	95	95	CD
cord-023417-by18aczt	431	19	%	%	NN
cord-023417-by18aczt	431	20	CI	ci	NN
cord-023417-by18aczt	431	21	:	:	:
cord-023417-by18aczt	431	22	1.7316	1.7316	CD
cord-023417-by18aczt	431	23	<	<	XX
cord-023417-by18aczt	431	24	OR	or	CC
cord-023417-by18aczt	431	25	<	<	XX
cord-023417-by18aczt	431	26	19.8963	19.8963	CD
cord-023417-by18aczt	431	27	)	)	-RRB-
cord-023417-by18aczt	431	28	.	.	.
cord-023417-by18aczt	432	1	Individuals	individual	NNS
cord-023417-by18aczt	432	2	with	with	IN
cord-023417-by18aczt	432	3	'	'	``
cord-023417-by18aczt	432	4	A	a	DT
cord-023417-by18aczt	432	5	'	'	''
cord-023417-by18aczt	432	6	allele	allele	NN
cord-023417-by18aczt	432	7	at	at	IN
cord-023417-by18aczt	432	8	position	position	NN
cord-023417-by18aczt	432	9	1011	1011	CD
cord-023417-by18aczt	432	10	showed	show	VBD
cord-023417-by18aczt	432	11	increased	increase	VBN
cord-023417-by18aczt	432	12	MBL	MBL	NNP
cord-023417-by18aczt	432	13	levels	level	NNS
cord-023417-by18aczt	432	14	,	,	,
cord-023417-by18aczt	432	15	activity	activity	NN
cord-023417-by18aczt	432	16	and	and	CC
cord-023417-by18aczt	432	17	disease	disease	NN
cord-023417-by18aczt	432	18	severity	severity	NN
cord-023417-by18aczt	432	19	.	.	.
cord-023417-by18aczt	433	1	Our	-PRON-	PRP$
cord-023417-by18aczt	433	2	results	result	NNS
cord-023417-by18aczt	433	3	suggest	suggest	VBP
cord-023417-by18aczt	433	4	that	that	IN
cord-023417-by18aczt	433	5	'	'	``
cord-023417-by18aczt	433	6	A	a	DT
cord-023417-by18aczt	433	7	'	'	''
cord-023417-by18aczt	433	8	allele	allele	NN
cord-023417-by18aczt	433	9	at	at	IN
cord-023417-by18aczt	433	10	position	position	NN
cord-023417-by18aczt	433	11	1011	1011	CD
cord-023417-by18aczt	433	12	leading	lead	VBG
cord-023417-by18aczt	433	13	to	to	IN
cord-023417-by18aczt	433	14	high	high	JJ
cord-023417-by18aczt	433	15	MBL	MBL	NNP
cord-023417-by18aczt	433	16	levels	level	NNS
cord-023417-by18aczt	433	17	and	and	CC
cord-023417-by18aczt	433	18	complement	complement	NN
cord-023417-by18aczt	433	19	activity	activity	NN
cord-023417-by18aczt	433	20	may	may	MD
cord-023417-by18aczt	433	21	be	be	VB
cord-023417-by18aczt	433	22	contributing	contribute	VBG
cord-023417-by18aczt	433	23	to	to	IN
cord-023417-by18aczt	433	24	the	the	DT
cord-023417-by18aczt	433	25	severity	severity	NN
cord-023417-by18aczt	433	26	of	of	IN
cord-023417-by18aczt	433	27	bronchial	bronchial	JJ
cord-023417-by18aczt	433	28	asthma	asthma	NN
cord-023417-by18aczt	433	29	and	and	CC
cord-023417-by18aczt	433	30	allergic	allergic	JJ
cord-023417-by18aczt	433	31	airway	airway	NN
cord-023417-by18aczt	433	32	inflammation	inflammation	NN
cord-023417-by18aczt	433	33	.	.	.
cord-023417-by18aczt	434	1	Serum	serum	NN
cord-023417-by18aczt	434	2	resistance	resistance	NN
cord-023417-by18aczt	434	3	of	of	IN
cord-023417-by18aczt	434	4	Borrelia	Borrelia	NNP
cord-023417-by18aczt	434	5	burgdorferi	burgdorferi	NN
cord-023417-by18aczt	434	6	strains	strain	NNS
cord-023417-by18aczt	434	7	belonging	belong	VBG
cord-023417-by18aczt	434	8	to	to	IN
cord-023417-by18aczt	434	9	the	the	DT
cord-023417-by18aczt	434	10	B.	B.	NNP
cord-023417-by18aczt	434	11	afzelii	afzelii	NNP
cord-023417-by18aczt	434	12	and	and	CC
cord-023417-by18aczt	434	13	B.	B.	NNP
cord-023417-by18aczt	434	14	burgdorferi	burgdorferi	NNP
cord-023417-by18aczt	434	15	sensu	sensu	NNP
cord-023417-by18aczt	434	16	stricto	stricto	NNP
cord-023417-by18aczt	434	17	genospecies	genospecies	NNP
cord-023417-by18aczt	434	18	is	be	VBZ
cord-023417-by18aczt	434	19	dependent	dependent	JJ
cord-023417-by18aczt	434	20	on	on	IN
cord-023417-by18aczt	434	21	binding	bind	VBG
cord-023417-by18aczt	434	22	of	of	IN
cord-023417-by18aczt	434	23	complement	complement	JJ
cord-023417-by18aczt	434	24	inhibitor	inhibitor	NN
cord-023417-by18aczt	434	25	factor	factor	NN
cord-023417-by18aczt	434	26	H.	h.	NN
cord-023417-by18aczt	435	1	We	-PRON-	PRP
cord-023417-by18aczt	435	2	recently	recently	RB
cord-023417-by18aczt	435	3	reported	report	VBD
cord-023417-by18aczt	435	4	that	that	IN
cord-023417-by18aczt	435	5	factor	factor	NN
cord-023417-by18aczt	435	6	H	h	NN
cord-023417-by18aczt	435	7	binding	binding	NN
cord-023417-by18aczt	435	8	by	by	IN
cord-023417-by18aczt	435	9	B.	B.	NNP
cord-023417-by18aczt	435	10	burgdorferi	burgdorferi	NNP
cord-023417-by18aczt	435	11	is	be	VBZ
cord-023417-by18aczt	435	12	due	due	JJ
cord-023417-by18aczt	435	13	to	to	IN
cord-023417-by18aczt	435	14	inducible	inducible	JJ
cord-023417-by18aczt	435	15	expression	expression	NN
cord-023417-by18aczt	435	16	of	of	IN
cord-023417-by18aczt	435	17	several	several	JJ
cord-023417-by18aczt	435	18	approximately	approximately	RB
cord-023417-by18aczt	435	19	20	20	CD
cord-023417-by18aczt	435	20	kDa	kDa	NNS
cord-023417-by18aczt	435	21	plasmid	plasmid	NN
cord-023417-by18aczt	435	22	-	-	HYPH
cord-023417-by18aczt	435	23	encoded	encode	VBN
cord-023417-by18aczt	435	24	,	,	,
cord-023417-by18aczt	435	25	surface	surface	NN
cord-023417-by18aczt	435	26	-	-	HYPH
cord-023417-by18aczt	435	27	exposed	expose	VBN
cord-023417-by18aczt	435	28	lipoproteins	lipoprotein	NNS
cord-023417-by18aczt	435	29	related	relate	VBN
cord-023417-by18aczt	435	30	to	to	IN
cord-023417-by18aczt	435	31	OspE	OspE	NNP
cord-023417-by18aczt	435	32	(	(	-LRB-
cord-023417-by18aczt	435	33	e.g.	e.g.	RB
cord-023417-by18aczt	435	34	ErpA	ErpA	NNP
cord-023417-by18aczt	435	35	,	,	,
cord-023417-by18aczt	435	36	ErpP	ErpP	NNP
cord-023417-by18aczt	435	37	and	and	CC
cord-023417-by18aczt	435	38	P21	P21	NNP
cord-023417-by18aczt	435	39	)	)	-RRB-
cord-023417-by18aczt	435	40	.	.	.
cord-023417-by18aczt	436	1	In	in	IN
cord-023417-by18aczt	436	2	addition	addition	NN
cord-023417-by18aczt	436	3	,	,	,
cord-023417-by18aczt	436	4	a	a	DT
cord-023417-by18aczt	436	5	second	second	JJ
cord-023417-by18aczt	436	6	class	class	NN
cord-023417-by18aczt	436	7	of	of	IN
cord-023417-by18aczt	436	8	factor	factor	NN
cord-023417-by18aczt	436	9	H	h	NN
cord-023417-by18aczt	436	10	-	-	HYPH
cord-023417-by18aczt	436	11	binding	bind	VBG
cord-023417-by18aczt	436	12	proteins	protein	NNS
cord-023417-by18aczt	436	13	of	of	IN
cord-023417-by18aczt	436	14	approximately	approximately	RB
cord-023417-by18aczt	436	15	27	27	CD
cord-023417-by18aczt	436	16	-	-	SYM
cord-023417-by18aczt	436	17	35	35	CD
cord-023417-by18aczt	436	18	kDa	kDa	NNP
cord-023417-by18aczt	436	19	has	have	VBZ
cord-023417-by18aczt	436	20	been	be	VBN
cord-023417-by18aczt	436	21	described	describe	VBN
cord-023417-by18aczt	436	22	.	.	.
cord-023417-by18aczt	437	1	The	the	DT
cord-023417-by18aczt	437	2	OspE	OspE	NNP
cord-023417-by18aczt	437	3	-	-	HYPH
cord-023417-by18aczt	437	4	related	relate	VBN
cord-023417-by18aczt	437	5	lipoproteins	lipoprotein	NNS
cord-023417-by18aczt	437	6	are	be	VBP
cord-023417-by18aczt	437	7	dramatically	dramatically	RB
cord-023417-by18aczt	437	8	induced	induce	VBN
cord-023417-by18aczt	437	9	by	by	IN
cord-023417-by18aczt	437	10	B.	B.	NNP
cord-023417-by18aczt	437	11	burgdorferi	burgdorferi	NN
cord-023417-by18aczt	437	12	during	during	IN
cord-023417-by18aczt	437	13	transmission	transmission	NN
cord-023417-by18aczt	437	14	from	from	IN
cord-023417-by18aczt	437	15	its	-PRON-	PRP$
cord-023417-by18aczt	437	16	tick	tick	NN
cord-023417-by18aczt	437	17	vector	vector	NN
cord-023417-by18aczt	437	18	into	into	IN
cord-023417-by18aczt	437	19	the	the	DT
cord-023417-by18aczt	437	20	mammalian	mammalian	JJ
cord-023417-by18aczt	437	21	host	host	NN
cord-023417-by18aczt	437	22	.	.	.
cord-023417-by18aczt	438	1	The	the	DT
cord-023417-by18aczt	438	2	induction	induction	NN
cord-023417-by18aczt	438	3	of	of	IN
cord-023417-by18aczt	438	4	OspE	OspE	NNP
cord-023417-by18aczt	438	5	-	-	HYPH
cord-023417-by18aczt	438	6	related	relate	VBN
cord-023417-by18aczt	438	7	lipoproteins	lipoprotein	NNS
cord-023417-by18aczt	438	8	during	during	IN
cord-023417-by18aczt	438	9	mammalian	mammalian	JJ
cord-023417-by18aczt	438	10	infection	infection	NN
cord-023417-by18aczt	438	11	may	may	MD
cord-023417-by18aczt	438	12	play	play	VB
cord-023417-by18aczt	438	13	a	a	DT
cord-023417-by18aczt	438	14	key	key	JJ
cord-023417-by18aczt	438	15	a	a	DT
cord-023417-by18aczt	438	16	role	role	NN
cord-023417-by18aczt	438	17	in	in	IN
cord-023417-by18aczt	438	18	the	the	DT
cord-023417-by18aczt	438	19	borrelial	borrelial	JJ
cord-023417-by18aczt	438	20	evasion	evasion	NN
cord-023417-by18aczt	438	21	of	of	IN
cord-023417-by18aczt	438	22	the	the	DT
cord-023417-by18aczt	438	23	host	host	NN
cord-023417-by18aczt	438	24	's	's	POS
cord-023417-by18aczt	438	25	immune	immune	JJ
cord-023417-by18aczt	438	26	system	system	NN
cord-023417-by18aczt	438	27	.	.	.
cord-023417-by18aczt	439	1	The	the	DT
cord-023417-by18aczt	439	2	goal	goal	NN
cord-023417-by18aczt	439	3	of	of	IN
cord-023417-by18aczt	439	4	the	the	DT
cord-023417-by18aczt	439	5	present	present	JJ
cord-023417-by18aczt	439	6	study	study	NN
cord-023417-by18aczt	439	7	was	be	VBD
cord-023417-by18aczt	439	8	to	to	TO
cord-023417-by18aczt	439	9	define	define	VB
cord-023417-by18aczt	439	10	the	the	DT
cord-023417-by18aczt	439	11	factor	factor	NN
cord-023417-by18aczt	439	12	H	h	NN
cord-023417-by18aczt	439	13	-	-	HYPH
cord-023417-by18aczt	439	14	binding	bind	VBG
cord-023417-by18aczt	439	15	regions	region	NNS
cord-023417-by18aczt	439	16	of	of	IN
cord-023417-by18aczt	439	17	OspE	ospe	NN
cord-023417-by18aczt	439	18	-	-	HYPH
cord-023417-by18aczt	439	19	related	relate	VBN
cord-023417-by18aczt	439	20	proteins	protein	NNS
cord-023417-by18aczt	439	21	using	use	VBG
cord-023417-by18aczt	439	22	mutagenesis	mutagenesis	NN
cord-023417-by18aczt	439	23	,	,	,
cord-023417-by18aczt	439	24	peptide	peptide	NN
cord-023417-by18aczt	439	25	mapping	mapping	NN
cord-023417-by18aczt	439	26	and	and	CC
cord-023417-by18aczt	439	27	surface	surface	NN
cord-023417-by18aczt	439	28	plasmon	plasmon	NNP
cord-023417-by18aczt	439	29	resonance	resonance	NN
cord-023417-by18aczt	439	30	analysis	analysis	NN
cord-023417-by18aczt	439	31	(	(	-LRB-
cord-023417-by18aczt	439	32	Biacore	Biacore	NNP
cord-023417-by18aczt	439	33	)	)	-RRB-
cord-023417-by18aczt	439	34	.	.	.
cord-023417-by18aczt	440	1	The	the	DT
cord-023417-by18aczt	440	2	combined	combine	VBN
cord-023417-by18aczt	440	3	studies	study	NNS
cord-023417-by18aczt	440	4	revealed	reveal	VBD
cord-023417-by18aczt	440	5	that	that	IN
cord-023417-by18aczt	440	6	the	the	DT
cord-023417-by18aczt	440	7	C	c	NN
cord-023417-by18aczt	440	8	-	-	HYPH
cord-023417-by18aczt	440	9	terminal	terminal	NN
cord-023417-by18aczt	440	10	regions	region	NNS
cord-023417-by18aczt	440	11	of	of	IN
cord-023417-by18aczt	440	12	both	both	CC
cord-023417-by18aczt	440	13	human	human	JJ
cord-023417-by18aczt	440	14	and	and	CC
cord-023417-by18aczt	440	15	mouse	mouse	NN
cord-023417-by18aczt	440	16	factor	factor	NN
cord-023417-by18aczt	440	17	H	H	NNP
cord-023417-by18aczt	440	18	(	(	-LRB-
cord-023417-by18aczt	440	19	SCRs	SCRs	NNP
cord-023417-by18aczt	440	20	18	18	CD
cord-023417-by18aczt	440	21	-	-	SYM
cord-023417-by18aczt	440	22	20	20	CD
cord-023417-by18aczt	440	23	)	)	-RRB-
cord-023417-by18aczt	440	24	specifically	specifically	RB
cord-023417-by18aczt	440	25	bind	bind	VB
cord-023417-by18aczt	440	26	to	to	IN
cord-023417-by18aczt	440	27	OspE	OspE	NNP
cord-023417-by18aczt	440	28	-	-	HYPH
cord-023417-by18aczt	440	29	related	relate	VBN
cord-023417-by18aczt	440	30	lipoproteins	lipoprotein	NNS
cord-023417-by18aczt	440	31	.	.	.
cord-023417-by18aczt	441	1	We	-PRON-	PRP
cord-023417-by18aczt	441	2	also	also	RB
cord-023417-by18aczt	441	3	found	find	VBD
cord-023417-by18aczt	441	4	FHR-1	FHR-1	NNP
cord-023417-by18aczt	441	5	,	,	,
cord-023417-by18aczt	442	1	whose	whose	WP$
cord-023417-by18aczt	442	2	C	C	NNP
cord-023417-by18aczt	442	3	-	-	HYPH
cord-023417-by18aczt	442	4	terminal	terminal	NN
cord-023417-by18aczt	442	5	SCRs	scr	NNS
cord-023417-by18aczt	442	6	3	3	CD
cord-023417-by18aczt	442	7	-	-	SYM
cord-023417-by18aczt	442	8	5	5	CD
cord-023417-by18aczt	442	9	are	be	VBP
cord-023417-by18aczt	442	10	homologous	homologous	JJ
cord-023417-by18aczt	442	11	to	to	IN
cord-023417-by18aczt	442	12	SCRs	scr	NNS
cord-023417-by18aczt	442	13	18	18	CD
cord-023417-by18aczt	442	14	-	-	SYM
cord-023417-by18aczt	442	15	20	20	CD
cord-023417-by18aczt	442	16	of	of	IN
cord-023417-by18aczt	442	17	factor	factor	NN
cord-023417-by18aczt	442	18	H	h	NN
cord-023417-by18aczt	442	19	,	,	,
cord-023417-by18aczt	442	20	to	to	TO
cord-023417-by18aczt	442	21	bind	bind	VB
cord-023417-by18aczt	442	22	to	to	IN
cord-023417-by18aczt	442	23	OspE.	OspE.	NNP
cord-023417-by18aczt	443	1	Peptide	peptide	NN
cord-023417-by18aczt	443	2	mapping	mapping	NN
cord-023417-by18aczt	443	3	revealed	reveal	VBD
cord-023417-by18aczt	443	4	five	five	CD
cord-023417-by18aczt	443	5	putative	putative	JJ
cord-023417-by18aczt	443	6	regions	region	NNS
cord-023417-by18aczt	443	7	(	(	-LRB-
cord-023417-by18aczt	443	8	designated	designate	VBN
cord-023417-by18aczt	443	9	I	I	NNP
cord-023417-by18aczt	443	10	-	-	HYPH
cord-023417-by18aczt	443	11	V	V	NNP
cord-023417-by18aczt	443	12	)	)	-RRB-
cord-023417-by18aczt	443	13	in	in	IN
cord-023417-by18aczt	443	14	OspE	OspE	NNP
cord-023417-by18aczt	443	15	that	that	WDT
cord-023417-by18aczt	443	16	could	could	MD
cord-023417-by18aczt	443	17	directly	directly	RB
cord-023417-by18aczt	443	18	interact	interact	VB
cord-023417-by18aczt	443	19	with	with	IN
cord-023417-by18aczt	443	20	factor	factor	NN
cord-023417-by18aczt	443	21	H.	h.	NN
cord-023417-by18aczt	443	22	Deleting	delete	VBG
cord-023417-by18aczt	443	23	the	the	DT
cord-023417-by18aczt	443	24	C	C	NNP
cord-023417-by18aczt	443	25	-	-	HYPH
cord-023417-by18aczt	443	26	terminal	terminal	NN
cord-023417-by18aczt	443	27	15	15	CD
cord-023417-by18aczt	443	28	amino	amino	NN
cord-023417-by18aczt	443	29	acid	acid	NN
cord-023417-by18aczt	443	30	residues	residue	NNS
cord-023417-by18aczt	443	31	from	from	IN
cord-023417-by18aczt	443	32	region	region	NN
cord-023417-by18aczt	443	33	V	v	NN
cord-023417-by18aczt	443	34	of	of	IN
cord-023417-by18aczt	443	35	P21	P21	NNP
cord-023417-by18aczt	443	36	abolished	abolish	VBD
cord-023417-by18aczt	443	37	its	-PRON-	PRP$
cord-023417-by18aczt	443	38	ability	ability	NN
cord-023417-by18aczt	443	39	to	to	TO
cord-023417-by18aczt	443	40	bind	bind	VB
cord-023417-by18aczt	443	41	factor	factor	NN
cord-023417-by18aczt	443	42	H.	h.	NN
cord-023417-by18aczt	444	1	At	at	IN
cord-023417-by18aczt	444	2	the	the	DT
cord-023417-by18aczt	444	3	same	same	JJ
cord-023417-by18aczt	444	4	time	time	NN
cord-023417-by18aczt	444	5	,	,	,
cord-023417-by18aczt	444	6	however	however	RB
cord-023417-by18aczt	444	7	,	,	,
cord-023417-by18aczt	444	8	synthetic	synthetic	JJ
cord-023417-by18aczt	444	9	peptides	peptide	NNS
cord-023417-by18aczt	444	10	corresponding	correspond	VBG
cord-023417-by18aczt	444	11	to	to	IN
cord-023417-by18aczt	444	12	the	the	DT
cord-023417-by18aczt	444	13	C	C	NNP
cord-023417-by18aczt	444	14	-	-	HYPH
cord-023417-by18aczt	444	15	termini	termini	NNP
cord-023417-by18aczt	444	16	of	of	IN
cord-023417-by18aczt	444	17	OspE	OspE	NNP
cord-023417-by18aczt	444	18	,	,	,
cord-023417-by18aczt	444	19	P21	P21	NNP
cord-023417-by18aczt	444	20	and	and	CC
cord-023417-by18aczt	444	21	ErpP	ErpP	NNP
cord-023417-by18aczt	444	22	did	do	VBD
cord-023417-by18aczt	444	23	not	not	RB
cord-023417-by18aczt	444	24	inhibit	inhibit	VB
cord-023417-by18aczt	444	25	factor	factor	NN
cord-023417-by18aczt	444	26	H	h	NN
cord-023417-by18aczt	444	27	binding	bind	VBG
cord-023417-by18aczt	444	28	to	to	IN
cord-023417-by18aczt	444	29	OspE.	ospe.	XX
cord-023417-by18aczt	445	1	Thus	thus	RB
cord-023417-by18aczt	445	2	,	,	,
cord-023417-by18aczt	445	3	the	the	DT
cord-023417-by18aczt	445	4	C	c	NN
cord-023417-by18aczt	445	5	-	-	HYPH
cord-023417-by18aczt	445	6	terminal	terminal	NN
cord-023417-by18aczt	445	7	-	-	HYPH
cord-023417-by18aczt	445	8	binding	bind	VBG
cord-023417-by18aczt	445	9	region	region	NN
cord-023417-by18aczt	445	10	V	v	NN
cord-023417-by18aczt	445	11	appears	appear	VBZ
cord-023417-by18aczt	445	12	to	to	TO
cord-023417-by18aczt	445	13	be	be	VB
cord-023417-by18aczt	445	14	necessary	necessary	JJ
cord-023417-by18aczt	445	15	but	but	CC
cord-023417-by18aczt	445	16	not	not	RB
cord-023417-by18aczt	445	17	sufficient	sufficient	JJ
cord-023417-by18aczt	445	18	for	for	IN
cord-023417-by18aczt	445	19	factor	factor	NN
cord-023417-by18aczt	445	20	H	h	NN
cord-023417-by18aczt	445	21	binding	binding	NN
cord-023417-by18aczt	445	22	.	.	.
cord-023417-by18aczt	446	1	When	when	WRB
cord-023417-by18aczt	446	2	a	a	DT
cord-023417-by18aczt	446	3	more	more	RBR
cord-023417-by18aczt	446	4	specific	specific	JJ
cord-023417-by18aczt	446	5	mutation	mutation	NN
cord-023417-by18aczt	446	6	strategy	strategy	NN
cord-023417-by18aczt	446	7	was	be	VBD
cord-023417-by18aczt	446	8	employed	employ	VBN
cord-023417-by18aczt	446	9	,	,	,
cord-023417-by18aczt	446	10	where	where	WRB
cord-023417-by18aczt	446	11	single	single	JJ
cord-023417-by18aczt	446	12	amino	amino	NN
cord-023417-by18aczt	446	13	acid	acid	NN
cord-023417-by18aczt	446	14	residues	residue	NNS
cord-023417-by18aczt	446	15	in	in	IN
cord-023417-by18aczt	446	16	peptides	peptide	NNS
cord-023417-by18aczt	446	17	spanning	span	VBG
cord-023417-by18aczt	446	18	over	over	IN
cord-023417-by18aczt	446	19	the	the	DT
cord-023417-by18aczt	446	20	factor	factor	NN
cord-023417-by18aczt	446	21	H	h	NN
cord-023417-by18aczt	446	22	-	-	HYPH
cord-023417-by18aczt	446	23	binding	bind	VBG
cord-023417-by18aczt	446	24	regions	region	NNS
cord-023417-by18aczt	446	25	were	be	VBD
cord-023417-by18aczt	446	26	mutated	mutate	VBN
cord-023417-by18aczt	446	27	to	to	IN
cord-023417-by18aczt	446	28	alanines	alanine	NNS
cord-023417-by18aczt	446	29	,	,	,
cord-023417-by18aczt	446	30	we	-PRON-	PRP
cord-023417-by18aczt	446	31	observed	observe	VBD
cord-023417-by18aczt	446	32	that	that	IN
cord-023417-by18aczt	446	33	lysines	lysine	NNS
cord-023417-by18aczt	446	34	in	in	IN
cord-023417-by18aczt	446	35	the	the	DT
cord-023417-by18aczt	446	36	factor	factor	NN
cord-023417-by18aczt	446	37	H	h	NN
cord-023417-by18aczt	446	38	-	-	HYPH
cord-023417-by18aczt	446	39	binding	bind	VBG
cord-023417-by18aczt	446	40	regions	region	NNS
cord-023417-by18aczt	446	41	of	of	IN
cord-023417-by18aczt	446	42	OspE	OspE	NNP
cord-023417-by18aczt	446	43	were	be	VBD
cord-023417-by18aczt	446	44	required	require	VBN
cord-023417-by18aczt	446	45	for	for	IN
cord-023417-by18aczt	446	46	factor	factor	NN
cord-023417-by18aczt	446	47	H	h	NN
cord-023417-by18aczt	446	48	binding	binding	NN
cord-023417-by18aczt	446	49	.	.	.
cord-023417-by18aczt	447	1	The	the	DT
cord-023417-by18aczt	447	2	combined	combined	JJ
cord-023417-by18aczt	447	3	data	datum	NNS
cord-023417-by18aczt	447	4	have	have	VBP
cord-023417-by18aczt	447	5	revealed	reveal	VBN
cord-023417-by18aczt	447	6	that	that	IN
cord-023417-by18aczt	447	7	key	key	JJ
cord-023417-by18aczt	447	8	lysine	lysine	NN
cord-023417-by18aczt	447	9	residues	residue	NNS
cord-023417-by18aczt	447	10	in	in	IN
cord-023417-by18aczt	447	11	OspE	OspE	NNP
cord-023417-by18aczt	447	12	-	-	HYPH
cord-023417-by18aczt	447	13	related	relate	VBN
cord-023417-by18aczt	447	14	lipoproteins	lipoprotein	NNS
cord-023417-by18aczt	447	15	and	and	CC
cord-023417-by18aczt	447	16	ionic	ionic	JJ
cord-023417-by18aczt	447	17	interactions	interaction	NNS
cord-023417-by18aczt	447	18	are	be	VBP
cord-023417-by18aczt	447	19	crucial	crucial	JJ
cord-023417-by18aczt	447	20	for	for	IN
cord-023417-by18aczt	447	21	factor	factor	NN
cord-023417-by18aczt	447	22	H	h	NN
cord-023417-by18aczt	447	23	interactions	interaction	NNS
cord-023417-by18aczt	447	24	.	.	.
cord-023417-by18aczt	448	1	Furthermore	furthermore	RB
cord-023417-by18aczt	448	2	,	,	,
cord-023417-by18aczt	448	3	binding	bind	VBG
cord-023417-by18aczt	448	4	of	of	IN
cord-023417-by18aczt	448	5	OspE	OspE	NNP
cord-023417-by18aczt	448	6	to	to	IN
cord-023417-by18aczt	448	7	the	the	DT
cord-023417-by18aczt	448	8	C	C	NNP
cord-023417-by18aczt	448	9	-	-	HYPH
cord-023417-by18aczt	448	10	termini	termini	NNP
cord-023417-by18aczt	448	11	of	of	IN
cord-023417-by18aczt	448	12	both	both	DT
cord-023417-by18aczt	448	13	mouse	mouse	NN
cord-023417-by18aczt	448	14	and	and	CC
cord-023417-by18aczt	448	15	human	human	NN
cord-023417-by18aczt	448	16	factor	factor	NN
cord-023417-by18aczt	449	1	H	H	NNP
cord-023417-by18aczt	449	2	suggests	suggest	VBZ
cord-023417-by18aczt	449	3	that	that	IN
cord-023417-by18aczt	449	4	Borrelia	Borrelia	NNP
cord-023417-by18aczt	449	5	spirochetes	spirochete	NNS
cord-023417-by18aczt	449	6	utilize	utilize	VBP
cord-023417-by18aczt	449	7	analogous	analogous	JJ
cord-023417-by18aczt	449	8	complement	complement	NN
cord-023417-by18aczt	449	9	resistance	resistance	NN
cord-023417-by18aczt	449	10	mechanisms	mechanism	NNS
cord-023417-by18aczt	449	11	in	in	IN
cord-023417-by18aczt	449	12	both	both	DT
cord-023417-by18aczt	449	13	rodents	rodent	NNS
cord-023417-by18aczt	449	14	and	and	CC
cord-023417-by18aczt	449	15	man	man	NN
cord-023417-by18aczt	449	16	.	.	.
cord-023417-by18aczt	450	1	In	in	IN
cord-023417-by18aczt	450	2	Borrelia	Borrelia	NNP
cord-023417-by18aczt	450	3	garinii	garinii	NN
cord-023417-by18aczt	450	4	strains	strain	NNS
cord-023417-by18aczt	450	5	,	,	,
cord-023417-by18aczt	450	6	which	which	WDT
cord-023417-by18aczt	450	7	in	in	IN
cord-023417-by18aczt	450	8	in	in	IN
cord-023417-by18aczt	450	9	vitro	vitro	FW
cord-023417-by18aczt	450	10	analyses	analysis	NNS
cord-023417-by18aczt	450	11	have	have	VBP
cord-023417-by18aczt	450	12	been	be	VBN
cord-023417-by18aczt	450	13	found	find	VBN
cord-023417-by18aczt	450	14	to	to	TO
cord-023417-by18aczt	450	15	be	be	VB
cord-023417-by18aczt	450	16	sensitive	sensitive	JJ
cord-023417-by18aczt	450	17	to	to	TO
cord-023417-by18aczt	450	18	complement	complement	VB
cord-023417-by18aczt	450	19	killing	killing	NN
cord-023417-by18aczt	450	20	,	,	,
cord-023417-by18aczt	450	21	differences	difference	NNS
cord-023417-by18aczt	450	22	in	in	IN
cord-023417-by18aczt	450	23	the	the	DT
cord-023417-by18aczt	450	24	OspE	OspE	NNP
cord-023417-by18aczt	450	25	sequences	sequence	NNS
cord-023417-by18aczt	450	26	as	as	RB
cord-023417-by18aczt	450	27	well	well	RB
cord-023417-by18aczt	450	28	as	as	IN
cord-023417-by18aczt	450	29	in	in	IN
cord-023417-by18aczt	450	30	the	the	DT
cord-023417-by18aczt	450	31	expression	expression	NN
cord-023417-by18aczt	450	32	of	of	IN
cord-023417-by18aczt	450	33	factor	factor	NN
cord-023417-by18aczt	450	34	H	h	NN
cord-023417-by18aczt	450	35	-	-	HYPH
cord-023417-by18aczt	450	36	binding	bind	VBG
cord-023417-by18aczt	450	37	proteins	protein	NNS
cord-023417-by18aczt	450	38	may	may	MD
cord-023417-by18aczt	450	39	account	account	VB
cord-023417-by18aczt	450	40	for	for	IN
cord-023417-by18aczt	450	41	their	-PRON-	PRP$
cord-023417-by18aczt	450	42	susceptibility	susceptibility	NN
cord-023417-by18aczt	450	43	to	to	IN
cord-023417-by18aczt	450	44	serum	serum	NN
cord-023417-by18aczt	450	45	lysis	lysis	NN
cord-023417-by18aczt	450	46	.	.	.
cord-023417-by18aczt	451	1	Role	role	NN
cord-023417-by18aczt	451	2	of	of	IN
cord-023417-by18aczt	451	3	YadA	YadA	NNP
cord-023417-by18aczt	451	4	,	,	,
cord-023417-by18aczt	451	5	Ail	Ail	NNP
cord-023417-by18aczt	451	6	and	and	CC
cord-023417-by18aczt	451	7	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-023417-by18aczt	451	8	in	in	IN
cord-023417-by18aczt	451	9	Serum	Serum	NNP
cord-023417-by18aczt	451	10	Resistance	Resistance	NNP
cord-023417-by18aczt	451	11	of	of	IN
cord-023417-by18aczt	451	12	Yersinia	Yersinia	NNP
cord-023417-by18aczt	451	13	enterocolitica	enterocolitica	NNP
cord-023417-by18aczt	451	14	Serotype	Serotype	NNP
cord-023417-by18aczt	452	1	O:3	O:3	NNP
cord-023417-by18aczt	452	2	Mannan	Mannan	NNP
cord-023417-by18aczt	452	3	-	-	HYPH
cord-023417-by18aczt	452	4	binding	bind	VBG
cord-023417-by18aczt	452	5	lectin	lectin	NN
cord-023417-by18aczt	452	6	(	(	-LRB-
cord-023417-by18aczt	452	7	MBL	MBL	NNP
cord-023417-by18aczt	452	8	)	)	-RRB-
cord-023417-by18aczt	452	9	,	,	,
cord-023417-by18aczt	452	10	L	l	NN
cord-023417-by18aczt	452	11	-	-	HYPH
cord-023417-by18aczt	452	12	ficolin	ficolin	NNP
cord-023417-by18aczt	452	13	and	and	CC
cord-023417-by18aczt	452	14	H	h	NN
cord-023417-by18aczt	452	15	-	-	HYPH
cord-023417-by18aczt	452	16	ficolin	ficolin	NNP
cord-023417-by18aczt	452	17	are	be	VBP
cord-023417-by18aczt	452	18	pattern	pattern	NN
cord-023417-by18aczt	452	19	recognition	recognition	NN
cord-023417-by18aczt	452	20	molecules	molecule	NNS
cord-023417-by18aczt	452	21	of	of	IN
cord-023417-by18aczt	452	22	the	the	DT
cord-023417-by18aczt	452	23	innate	innate	JJ
cord-023417-by18aczt	452	24	immune	immune	JJ
cord-023417-by18aczt	452	25	system	system	NN
cord-023417-by18aczt	452	26	.	.	.
cord-023417-by18aczt	453	1	We	-PRON-	PRP
cord-023417-by18aczt	453	2	investigated	investigate	VBD
cord-023417-by18aczt	453	3	the	the	DT
cord-023417-by18aczt	453	4	ability	ability	NN
cord-023417-by18aczt	453	5	of	of	IN
cord-023417-by18aczt	453	6	these	these	DT
cord-023417-by18aczt	453	7	molecules	molecule	NNS
cord-023417-by18aczt	453	8	to	to	TO
cord-023417-by18aczt	453	9	bind	bind	VB
cord-023417-by18aczt	453	10	to	to	IN
cord-023417-by18aczt	453	11	different	different	JJ
cord-023417-by18aczt	453	12	serotypes	serotype	NNS
cord-023417-by18aczt	453	13	and	and	CC
cord-023417-by18aczt	453	14	noncapsulated	noncapsulated	JJ
cord-023417-by18aczt	453	15	variants	variant	NNS
cord-023417-by18aczt	453	16	of	of	IN
cord-023417-by18aczt	453	17	Streptococcus	Streptococcus	NNP
cord-023417-by18aczt	453	18	pneumonia	pneumonia	NN
cord-023417-by18aczt	453	19	and	and	CC
cord-023417-by18aczt	453	20	Staphylococcus	Staphylococcus	NNP
cord-023417-by18aczt	453	21	aureus	aureus	NN
cord-023417-by18aczt	453	22	.	.	.
cord-023417-by18aczt	454	1	We	-PRON-	PRP
cord-023417-by18aczt	454	2	found	find	VBD
cord-023417-by18aczt	454	3	that	that	IN
cord-023417-by18aczt	454	4	MBL	MBL	NNP
cord-023417-by18aczt	454	5	binds	bind	VBZ
cord-023417-by18aczt	454	6	to	to	IN
cord-023417-by18aczt	454	7	noncapsulated	noncapsulated	NNP
cord-023417-by18aczt	454	8	S.	S.	NNP
cord-023417-by18aczt	454	9	aureus	aureus	NN
cord-023417-by18aczt	454	10	strain	strain	NN
cord-023417-by18aczt	454	11	(	(	-LRB-
cord-023417-by18aczt	454	12	Wood	wood	NN
cord-023417-by18aczt	454	13	)	)	-RRB-
cord-023417-by18aczt	454	14	but	but	CC
cord-023417-by18aczt	454	15	not	not	RB
cord-023417-by18aczt	454	16	any	any	DT
cord-023417-by18aczt	454	17	of	of	IN
cord-023417-by18aczt	454	18	the	the	DT
cord-023417-by18aczt	454	19	examined	examine	VBN
cord-023417-by18aczt	454	20	S.	S.	NNP
cord-023417-by18aczt	454	21	pneumoniae	pneumoniae	NN
cord-023417-by18aczt	454	22	serotypes	serotype	NNS
cord-023417-by18aczt	454	23	.	.	.
cord-023417-by18aczt	455	1	L	l	NN
cord-023417-by18aczt	455	2	-	-	HYPH
cord-023417-by18aczt	455	3	ficolin	ficolin	NNP
cord-023417-by18aczt	455	4	binds	bind	VBZ
cord-023417-by18aczt	455	5	to	to	IN
cord-023417-by18aczt	455	6	some	some	DT
cord-023417-by18aczt	455	7	capsulated	capsulated	JJ
cord-023417-by18aczt	455	8	S.	S.	NNP
cord-023417-by18aczt	455	9	pneumoniae	pneumoniae	NN
cord-023417-by18aczt	455	10	serotypes	serotype	NNS
cord-023417-by18aczt	455	11	(	(	-LRB-
cord-023417-by18aczt	455	12	11A	11a	NN
cord-023417-by18aczt	455	13	,	,	,
cord-023417-by18aczt	455	14	11D	11d	CD
cord-023417-by18aczt	455	15	and	and	CC
cord-023417-by18aczt	455	16	11F	11f	CD
cord-023417-by18aczt	455	17	)	)	-RRB-
cord-023417-by18aczt	455	18	as	as	RB
cord-023417-by18aczt	455	19	well	well	RB
cord-023417-by18aczt	455	20	as	as	IN
cord-023417-by18aczt	455	21	some	some	DT
cord-023417-by18aczt	455	22	capsulated	capsulated	JJ
cord-023417-by18aczt	455	23	S.	S.	NNP
cord-023417-by18aczt	455	24	aureus	aureus	NN
cord-023417-by18aczt	455	25	serotypes	serotype	NNS
cord-023417-by18aczt	455	26	(	(	-LRB-
cord-023417-by18aczt	455	27	Type-1	type-1	NN
cord-023417-by18aczt	455	28	,	,	,
cord-023417-by18aczt	455	29	-8	-8	NNP
cord-023417-by18aczt	455	30	,	,	,
cord-023417-by18aczt	455	31	-9	-9	NNP
cord-023417-by18aczt	455	32	,	,	,
cord-023417-by18aczt	455	33	-11	-11	NNP
cord-023417-by18aczt	455	34	and	and	CC
cord-023417-by18aczt	455	35	-12	-12	NNP
cord-023417-by18aczt	455	36	)	)	-RRB-
cord-023417-by18aczt	455	37	.	.	.
cord-023417-by18aczt	456	1	H	h	NN
cord-023417-by18aczt	456	2	-	-	HYPH
cord-023417-by18aczt	456	3	ficolin	ficolin	NN
cord-023417-by18aczt	456	4	does	do	VBZ
cord-023417-by18aczt	456	5	not	not	RB
cord-023417-by18aczt	456	6	bind	bind	VB
cord-023417-by18aczt	456	7	to	to	IN
cord-023417-by18aczt	456	8	any	any	DT
cord-023417-by18aczt	456	9	of	of	IN
cord-023417-by18aczt	456	10	the	the	DT
cord-023417-by18aczt	456	11	examined	examine	VBN
cord-023417-by18aczt	456	12	S.	S.	NNP
cord-023417-by18aczt	456	13	pneumoniae	pneumoniae	NN
cord-023417-by18aczt	456	14	and	and	CC
cord-023417-by18aczt	456	15	S.	S.	NNP
cord-023417-by18aczt	456	16	aureus	aureus	NN
cord-023417-by18aczt	456	17	serotypes	serotype	NNS
cord-023417-by18aczt	456	18	included	include	VBN
cord-023417-by18aczt	456	19	in	in	IN
cord-023417-by18aczt	456	20	this	this	DT
cord-023417-by18aczt	456	21	study	study	NN
cord-023417-by18aczt	456	22	but	but	CC
cord-023417-by18aczt	456	23	did	do	VBD
cord-023417-by18aczt	456	24	bind	bind	VB
cord-023417-by18aczt	456	25	to	to	IN
cord-023417-by18aczt	456	26	a	a	DT
cord-023417-by18aczt	456	27	strain	strain	NN
cord-023417-by18aczt	456	28	of	of	IN
cord-023417-by18aczt	456	29	Aerococcus	Aerococcus	NNP
cord-023417-by18aczt	456	30	viridans	viridan	NNS
cord-023417-by18aczt	456	31	.	.	.
cord-023417-by18aczt	457	1	When	when	WRB
cord-023417-by18aczt	457	2	bound	bind	VBN
cord-023417-by18aczt	457	3	to	to	IN
cord-023417-by18aczt	457	4	bacteria	bacteria	NNS
cord-023417-by18aczt	457	5	,	,	,
cord-023417-by18aczt	457	6	MBL	MBL	NNP
cord-023417-by18aczt	457	7	and	and	CC
cord-023417-by18aczt	457	8	H	H	NNP
cord-023417-by18aczt	457	9	-	-	HYPH
cord-023417-by18aczt	457	10	ficolin	ficolin	NNP
cord-023417-by18aczt	457	11	initiated	initiate	VBN
cord-023417-by18aczt	457	12	activation	activation	NN
cord-023417-by18aczt	457	13	of	of	IN
cord-023417-by18aczt	457	14	complement	complement	NN
cord-023417-by18aczt	457	15	factor	factor	NN
cord-023417-by18aczt	457	16	C4	c4	NN
cord-023417-by18aczt	457	17	,	,	,
cord-023417-by18aczt	457	18	whereas	whereas	IN
cord-023417-by18aczt	457	19	L	l	NN
cord-023417-by18aczt	457	20	-	-	HYPH
cord-023417-by18aczt	457	21	ficolin	ficolin	NNP
cord-023417-by18aczt	457	22	did	do	VBD
cord-023417-by18aczt	457	23	not	not	RB
cord-023417-by18aczt	457	24	.	.	.
cord-023417-by18aczt	458	1	During	during	IN
cord-023417-by18aczt	458	2	this	this	DT
cord-023417-by18aczt	458	3	study	study	NN
cord-023417-by18aczt	458	4	,	,	,
cord-023417-by18aczt	458	5	quantitative	quantitative	JJ
cord-023417-by18aczt	458	6	assays	assay	NNS
cord-023417-by18aczt	458	7	for	for	IN
cord-023417-by18aczt	458	8	the	the	DT
cord-023417-by18aczt	458	9	three	three	CD
cord-023417-by18aczt	458	10	proteins	protein	NNS
cord-023417-by18aczt	458	11	were	be	VBD
cord-023417-by18aczt	458	12	developed	develop	VBN
cord-023417-by18aczt	458	13	and	and	CC
cord-023417-by18aczt	458	14	the	the	DT
cord-023417-by18aczt	458	15	concentration	concentration	NN
cord-023417-by18aczt	458	16	in	in	IN
cord-023417-by18aczt	458	17	97	97	CD
cord-023417-by18aczt	458	18	plasma	plasma	NN
cord-023417-by18aczt	458	19	samples	sample	NNS
cord-023417-by18aczt	458	20	were	be	VBD
cord-023417-by18aczt	458	21	determined	determine	VBN
cord-023417-by18aczt	458	22	and	and	CC
cord-023417-by18aczt	458	23	the	the	DT
cord-023417-by18aczt	458	24	median	median	JJ
cord-023417-by18aczt	458	25	values	value	NNS
cord-023417-by18aczt	458	26	were	be	VBD
cord-023417-by18aczt	458	27	estimated	estimate	VBN
cord-023417-by18aczt	458	28	at	at	IN
cord-023417-by18aczt	458	29	0.8	0.8	CD
cord-023417-by18aczt	458	30	mg	mg	NN
cord-023417-by18aczt	458	31	of	of	IN
cord-023417-by18aczt	458	32	MBL	MBL	NNP
cord-023417-by18aczt	458	33	/	/	SYM
cord-023417-by18aczt	458	34	ml	ml	NNS
cord-023417-by18aczt	458	35	,	,	,
cord-023417-by18aczt	458	36	3.3	3.3	CD
cord-023417-by18aczt	458	37	mg	mg	NN
cord-023417-by18aczt	458	38	of	of	IN
cord-023417-by18aczt	458	39	L	L	NNP
cord-023417-by18aczt	458	40	-	-	HYPH
cord-023417-by18aczt	458	41	ficolin	ficolin	NNP
cord-023417-by18aczt	458	42	/	/	SYM
cord-023417-by18aczt	458	43	ml	ml	NN
cord-023417-by18aczt	458	44	and	and	CC
cord-023417-by18aczt	458	45	18.4	18.4	CD
cord-023417-by18aczt	458	46	mg	mg	NNS
cord-023417-by18aczt	458	47	of	of	IN
cord-023417-by18aczt	458	48	H	H	NNP
cord-023417-by18aczt	458	49	-	-	HYPH
cord-023417-by18aczt	458	50	ficolin/	ficolin/	NNP
cord-023417-by18aczt	458	51	ml	ml	NN
cord-023417-by18aczt	458	52	,	,	,
cord-023417-by18aczt	458	53	respectively	respectively	RB
cord-023417-by18aczt	458	54	.	.	.
cord-023417-by18aczt	459	1	The	the	DT
cord-023417-by18aczt	459	2	absence	absence	NN
cord-023417-by18aczt	459	3	of	of	IN
cord-023417-by18aczt	459	4	early	early	JJ
cord-023417-by18aczt	459	5	complement	complement	NN
cord-023417-by18aczt	459	6	components	component	NNS
cord-023417-by18aczt	459	7	(	(	-LRB-
cord-023417-by18aczt	459	8	C1	C1	NNP
cord-023417-by18aczt	459	9	,	,	,
cord-023417-by18aczt	459	10	C4	C4	NNP
cord-023417-by18aczt	459	11	and	and	CC
cord-023417-by18aczt	459	12	C2	C2	NNP
cord-023417-by18aczt	459	13	but	but	CC
cord-023417-by18aczt	459	14	not	not	RB
cord-023417-by18aczt	459	15	C3	C3	NNP
cord-023417-by18aczt	459	16	)	)	-RRB-
cord-023417-by18aczt	459	17	is	be	VBZ
cord-023417-by18aczt	459	18	a	a	DT
cord-023417-by18aczt	459	19	predisposing	predisposing	JJ
cord-023417-by18aczt	459	20	factor	factor	NN
cord-023417-by18aczt	459	21	for	for	IN
cord-023417-by18aczt	459	22	systemic	systemic	JJ
cord-023417-by18aczt	459	23	lupus	lupus	NN
cord-023417-by18aczt	459	24	erythematosus	erythematosus	NN
cord-023417-by18aczt	459	25	(	(	-LRB-
cord-023417-by18aczt	459	26	SLE	SLE	NNP
cord-023417-by18aczt	459	27	)	)	-RRB-
cord-023417-by18aczt	459	28	.	.	.
cord-023417-by18aczt	460	1	Recently	recently	RB
cord-023417-by18aczt	460	2	,	,	,
cord-023417-by18aczt	460	3	we	-PRON-	PRP
cord-023417-by18aczt	460	4	demonstrated	demonstrate	VBD
cord-023417-by18aczt	460	5	that	that	IN
cord-023417-by18aczt	460	6	,	,	,
cord-023417-by18aczt	460	7	in	in	IN
cord-023417-by18aczt	460	8	C4-deficient	c4-deficient	NN
cord-023417-by18aczt	460	9	(	(	-LRB-
cord-023417-by18aczt	460	10	C4	C4	NNP
cord-023417-by18aczt	460	11	def	def	NN
cord-023417-by18aczt	460	12	.	.	.
cord-023417-by18aczt	460	13	)	)	-RRB-
cord-023417-by18aczt	461	1	mice	mouse	NNS
cord-023417-by18aczt	461	2	,	,	,
cord-023417-by18aczt	461	3	IgM	igm	NN
cord-023417-by18aczt	461	4	-	-	HYPH
cord-023417-by18aczt	461	5	containing	contain	VBG
cord-023417-by18aczt	461	6	immune	immune	JJ
cord-023417-by18aczt	461	7	complexes	complex	NNS
cord-023417-by18aczt	461	8	(	(	-LRB-
cord-023417-by18aczt	461	9	IgM	IgM	NNP
cord-023417-by18aczt	461	10	-	-	HYPH
cord-023417-by18aczt	461	11	IC	IC	NNP
cord-023417-by18aczt	461	12	)	)	-RRB-
cord-023417-by18aczt	461	13	are	be	VBP
cord-023417-by18aczt	461	14	filtered	filter	VBN
cord-023417-by18aczt	461	15	by	by	IN
cord-023417-by18aczt	461	16	the	the	DT
cord-023417-by18aczt	461	17	splenic	splenic	JJ
cord-023417-by18aczt	461	18	barrier	barrier	NN
cord-023417-by18aczt	461	19	of	of	IN
cord-023417-by18aczt	461	20	marginal	marginal	JJ
cord-023417-by18aczt	461	21	zone	zone	NN
cord-023417-by18aczt	461	22	macrophages	macrophage	NNS
cord-023417-by18aczt	461	23	(	(	-LRB-
cord-023417-by18aczt	461	24	MZM	MZM	NNP
cord-023417-by18aczt	461	25	)	)	-RRB-
cord-023417-by18aczt	461	26	,	,	,
cord-023417-by18aczt	461	27	resulting	result	VBG
cord-023417-by18aczt	461	28	in	in	IN
cord-023417-by18aczt	461	29	an	an	DT
cord-023417-by18aczt	461	30	increased	increase	VBN
cord-023417-by18aczt	461	31	immune	immune	JJ
cord-023417-by18aczt	461	32	response	response	NN
cord-023417-by18aczt	461	33	against	against	IN
cord-023417-by18aczt	461	34	antigens	antigen	NNS
cord-023417-by18aczt	461	35	within	within	IN
cord-023417-by18aczt	461	36	these	these	DT
cord-023417-by18aczt	461	37	IgM	IgM	NNP
cord-023417-by18aczt	461	38	-	-	HYPH
cord-023417-by18aczt	461	39	IC	IC	NNP
cord-023417-by18aczt	461	40	,	,	,
cord-023417-by18aczt	461	41	but	but	CC
cord-023417-by18aczt	461	42	this	this	DT
cord-023417-by18aczt	461	43	could	could	MD
cord-023417-by18aczt	461	44	not	not	RB
cord-023417-by18aczt	461	45	be	be	VB
cord-023417-by18aczt	461	46	observed	observe	VBN
cord-023417-by18aczt	461	47	in	in	IN
cord-023417-by18aczt	461	48	wildtype	wildtype	NN
cord-023417-by18aczt	461	49	or	or	CC
cord-023417-by18aczt	461	50	C3	c3	NN
cord-023417-by18aczt	461	51	def	def	NN
cord-023417-by18aczt	461	52	.	.	.
cord-023417-by18aczt	462	1	mice	mouse	NNS
cord-023417-by18aczt	462	2	.	.	.
cord-023417-by18aczt	463	1	We	-PRON-	PRP
cord-023417-by18aczt	463	2	hypothesized	hypothesize	VBD
cord-023417-by18aczt	463	3	that	that	IN
cord-023417-by18aczt	463	4	splenic	splenic	JJ
cord-023417-by18aczt	463	5	CD11b	CD11b	NNS
cord-023417-by18aczt	463	6	þ	þ	CD
cord-023417-by18aczt	463	7	MZM	MZM	NNP
cord-023417-by18aczt	463	8	play	play	VBP
cord-023417-by18aczt	463	9	an	an	DT
cord-023417-by18aczt	463	10	important	important	JJ
cord-023417-by18aczt	463	11	role	role	NN
cord-023417-by18aczt	463	12	in	in	IN
cord-023417-by18aczt	463	13	the	the	DT
cord-023417-by18aczt	463	14	induction	induction	NN
cord-023417-by18aczt	463	15	of	of	IN
cord-023417-by18aczt	463	16	autoimmunity	autoimmunity	NN
cord-023417-by18aczt	463	17	,	,	,
cord-023417-by18aczt	463	18	and	and	CC
cord-023417-by18aczt	463	19	we	-PRON-	PRP
cord-023417-by18aczt	463	20	therefore	therefore	RB
cord-023417-by18aczt	463	21	analysed	analyse	VBD
cord-023417-by18aczt	463	22	their	-PRON-	PRP$
cord-023417-by18aczt	463	23	cytokine	cytokine	NN
cord-023417-by18aczt	463	24	profile	profile	NN
cord-023417-by18aczt	463	25	after	after	IN
cord-023417-by18aczt	463	26	isolation	isolation	NN
cord-023417-by18aczt	463	27	with	with	IN
cord-023417-by18aczt	463	28	the	the	DT
cord-023417-by18aczt	463	29	help	help	NN
cord-023417-by18aczt	463	30	of	of	IN
cord-023417-by18aczt	463	31	magnetic	magnetic	JJ
cord-023417-by18aczt	463	32	antibody	antibody	NN
cord-023417-by18aczt	463	33	cell	cell	NN
cord-023417-by18aczt	463	34	sorting	sorting	NN
cord-023417-by18aczt	463	35	.	.	.
cord-023417-by18aczt	464	1	mRNA	mRNA	NNP
cord-023417-by18aczt	464	2	was	be	VBD
cord-023417-by18aczt	464	3	isolated	isolate	VBN
cord-023417-by18aczt	464	4	,	,	,
cord-023417-by18aczt	464	5	and	and	CC
cord-023417-by18aczt	464	6	real	real	JJ
cord-023417-by18aczt	464	7	-	-	HYPH
cord-023417-by18aczt	464	8	time	time	NN
cord-023417-by18aczt	464	9	PCR	PCR	NNP
cord-023417-by18aczt	464	10	was	be	VBD
cord-023417-by18aczt	464	11	performed	perform	VBN
cord-023417-by18aczt	464	12	with	with	IN
cord-023417-by18aczt	464	13	specific	specific	JJ
cord-023417-by18aczt	464	14	primers	primer	NNS
cord-023417-by18aczt	464	15	for	for	IN
cord-023417-by18aczt	464	16	murine	murine	JJ
cord-023417-by18aczt	464	17	IFN	IFN	NNP
cord-023417-by18aczt	464	18	-	-	HYPH
cord-023417-by18aczt	464	19	g	g	NNP
cord-023417-by18aczt	464	20	(	(	-LRB-
cord-023417-by18aczt	464	21	IFN	IFN	NNP
cord-023417-by18aczt	464	22	-	-	HYPH
cord-023417-by18aczt	464	23	g	g	NNP
cord-023417-by18aczt	464	24	)	)	-RRB-
cord-023417-by18aczt	464	25	,	,	,
cord-023417-by18aczt	464	26	interleukin-12	interleukin-12	XX
cord-023417-by18aczt	464	27	(	(	-LRB-
cord-023417-by18aczt	464	28	IL-12	IL-12	NNP
cord-023417-by18aczt	464	29	)	)	-RRB-
cord-023417-by18aczt	464	30	and	and	CC
cord-023417-by18aczt	464	31	IFN	IFN	NNP
cord-023417-by18aczt	464	32	-	-	HYPH
cord-023417-by18aczt	464	33	a	a	NNP
cord-023417-by18aczt	464	34	(	(	-LRB-
cord-023417-by18aczt	464	35	IFN	IFN	NNP
cord-023417-by18aczt	464	36	-	-	HYPH
cord-023417-by18aczt	464	37	a	a	NN
cord-023417-by18aczt	464	38	)	)	-RRB-
cord-023417-by18aczt	464	39	.	.	.
cord-023417-by18aczt	465	1	We	-PRON-	PRP
cord-023417-by18aczt	465	2	observe	observe	VBP
cord-023417-by18aczt	465	3	a	a	DT
cord-023417-by18aczt	465	4	moderate	moderate	JJ
cord-023417-by18aczt	465	5	increase	increase	NN
cord-023417-by18aczt	465	6	of	of	IN
cord-023417-by18aczt	465	7	IL-12	IL-12	NNP
cord-023417-by18aczt	465	8	and	and	CC
cord-023417-by18aczt	465	9	IFN	IFN	NNP
cord-023417-by18aczt	465	10	-	-	HYPH
cord-023417-by18aczt	465	11	g	g	NNP
cord-023417-by18aczt	465	12	mRNA	mrna	NN
cord-023417-by18aczt	466	1	in	in	IN
cord-023417-by18aczt	467	1	CD11b	CD11b	NNPS
cord-023417-by18aczt	467	2	þ	þ	NNP
cord-023417-by18aczt	467	3	cells	cell	NNS
cord-023417-by18aczt	467	4	of	of	IN
cord-023417-by18aczt	467	5	C4	c4	NN
cord-023417-by18aczt	467	6	def	def	NN
cord-023417-by18aczt	467	7	.	.	.
cord-023417-by18aczt	468	1	mice	mouse	NNS
cord-023417-by18aczt	468	2	compared	compare	VBN
cord-023417-by18aczt	468	3	to	to	IN
cord-023417-by18aczt	468	4	wildtype	wildtype	NN
cord-023417-by18aczt	468	5	cells	cell	NNS
cord-023417-by18aczt	468	6	.	.	.
cord-023417-by18aczt	469	1	Surprisingly	surprisingly	RB
cord-023417-by18aczt	469	2	,	,	,
cord-023417-by18aczt	469	3	the	the	DT
cord-023417-by18aczt	469	4	concentration	concentration	NN
cord-023417-by18aczt	469	5	of	of	IN
cord-023417-by18aczt	469	6	IFN	IFN	NNP
cord-023417-by18aczt	469	7	-	-	:
cord-023417-by18aczt	469	8	a	a	DT
cord-023417-by18aczt	469	9	mRNA	mrna	NN
cord-023417-by18aczt	469	10	is	be	VBZ
cord-023417-by18aczt	469	11	six	six	CD
cord-023417-by18aczt	469	12	times	time	NNS
cord-023417-by18aczt	469	13	higher	high	JJR
cord-023417-by18aczt	469	14	in	in	IN
cord-023417-by18aczt	469	15	C4	c4	NN
cord-023417-by18aczt	469	16	def	def	NN
cord-023417-by18aczt	469	17	.	.	.
cord-023417-by18aczt	470	1	mice	mouse	NNS
cord-023417-by18aczt	470	2	.	.	.
cord-023417-by18aczt	471	1	Preliminary	preliminary	JJ
cord-023417-by18aczt	471	2	results	result	NNS
cord-023417-by18aczt	471	3	suggest	suggest	VBP
cord-023417-by18aczt	471	4	that	that	IN
cord-023417-by18aczt	471	5	mRNA	mrna	NN
cord-023417-by18aczt	471	6	in	in	IN
cord-023417-by18aczt	471	7	CD11b	CD11b	NNS
cord-023417-by18aczt	471	8	þ	þ	NNP
cord-023417-by18aczt	471	9	cells	cell	NNS
cord-023417-by18aczt	471	10	of	of	IN
cord-023417-by18aczt	471	11	C3	c3	NN
cord-023417-by18aczt	471	12	def	def	NN
cord-023417-by18aczt	471	13	.	.	.
cord-023417-by18aczt	472	1	mice	mice	NN
cord-023417-by18aczt	472	2	is	be	VBZ
cord-023417-by18aczt	472	3	even	even	RB
cord-023417-by18aczt	472	4	lower	low	JJR
cord-023417-by18aczt	472	5	than	than	IN
cord-023417-by18aczt	472	6	that	that	DT
cord-023417-by18aczt	472	7	in	in	IN
cord-023417-by18aczt	472	8	wt	wt	NN
cord-023417-by18aczt	472	9	.	.	.
cord-023417-by18aczt	473	1	Six	six	CD
cord-023417-by18aczt	473	2	hours	hour	NNS
cord-023417-by18aczt	473	3	following	follow	VBG
cord-023417-by18aczt	473	4	i.v	i.v	NNP
cord-023417-by18aczt	473	5	.	.	NNP
cord-023417-by18aczt	473	6	application	application	NN
cord-023417-by18aczt	473	7	of	of	IN
cord-023417-by18aczt	473	8	20	20	CD
cord-023417-by18aczt	473	9	mg	mg	NNS
cord-023417-by18aczt	473	10	of	of	IN
cord-023417-by18aczt	473	11	a	a	DT
cord-023417-by18aczt	473	12	Abstracts	Abstracts	NNPS
cord-023417-by18aczt	473	13	625	625	CD
cord-023417-by18aczt	473	14	..................................................................................................................................................................................................	..................................................................................................................................................................................................	.
cord-023417-by18aczt	474	1	murine	murine	JJ
cord-023417-by18aczt	474	2	monoclonal	monoclonal	NNP
cord-023417-by18aczt	474	3	IgM	IgM	NNP
cord-023417-by18aczt	474	4	anti	anti	JJ
cord-023417-by18aczt	474	5	-	-	JJ
cord-023417-by18aczt	474	6	dsDNA	dsdna	JJ
cord-023417-by18aczt	474	7	antibody	antibody	NN
cord-023417-by18aczt	474	8	,	,	,
cord-023417-by18aczt	474	9	production	production	NN
cord-023417-by18aczt	474	10	of	of	IN
cord-023417-by18aczt	474	11	IL-12	IL-12	NNP
cord-023417-by18aczt	474	12	,	,	,
cord-023417-by18aczt	474	13	IFN	IFN	NNP
cord-023417-by18aczt	474	14	-	-	HYPH
cord-023417-by18aczt	474	15	g	g	NNP
cord-023417-by18aczt	474	16	and	and	CC
cord-023417-by18aczt	474	17	IFN-	IFN-	NNP
cord-023417-by18aczt	475	1	a	a	DT
cord-023417-by18aczt	475	2	mRNA	mrna	NN
cord-023417-by18aczt	475	3	is	be	VBZ
cord-023417-by18aczt	475	4	increased	increase	VBN
cord-023417-by18aczt	475	5	in	in	IN
cord-023417-by18aczt	475	6	CD11b	CD11b	NNS
cord-023417-by18aczt	475	7	þ	þ	NNP
cord-023417-by18aczt	475	8	cells	cell	NNS
cord-023417-by18aczt	475	9	of	of	IN
cord-023417-by18aczt	475	10	both	both	DT
cord-023417-by18aczt	475	11	C4	c4	NN
cord-023417-by18aczt	475	12	def	def	NN
cord-023417-by18aczt	475	13	.	.	.
cord-023417-by18aczt	476	1	and	and	CC
cord-023417-by18aczt	476	2	wt	wt	NN
cord-023417-by18aczt	476	3	mice	mouse	NNS
cord-023417-by18aczt	476	4	.	.	.
cord-023417-by18aczt	477	1	Several	several	JJ
cord-023417-by18aczt	477	2	references	reference	NNS
cord-023417-by18aczt	477	3	described	describe	VBN
cord-023417-by18aczt	477	4	increased	increase	VBN
cord-023417-by18aczt	477	5	levels	level	NNS
cord-023417-by18aczt	477	6	of	of	IN
cord-023417-by18aczt	477	7	INF	inf	NN
cord-023417-by18aczt	477	8	-	-	,
cord-023417-by18aczt	477	9	a	a	NN
cord-023417-by18aczt	477	10	in	in	IN
cord-023417-by18aczt	477	11	patients	patient	NNS
cord-023417-by18aczt	477	12	with	with	IN
cord-023417-by18aczt	477	13	SLE	SLE	NNP
cord-023417-by18aczt	477	14	.	.	.
cord-023417-by18aczt	478	1	Dendritic	dendritic	JJ
cord-023417-by18aczt	478	2	cells	cell	NNS
cord-023417-by18aczt	478	3	are	be	VBP
cord-023417-by18aczt	478	4	discussed	discuss	VBN
cord-023417-by18aczt	478	5	as	as	IN
cord-023417-by18aczt	478	6	a	a	DT
cord-023417-by18aczt	478	7	major	major	JJ
cord-023417-by18aczt	478	8	source	source	NN
cord-023417-by18aczt	478	9	of	of	IN
cord-023417-by18aczt	478	10	IFN	IFN	NNP
cord-023417-by18aczt	478	11	-	-	HYPH
cord-023417-by18aczt	478	12	a	a	NN
cord-023417-by18aczt	478	13	.	.	.
cord-023417-by18aczt	479	1	Our	-PRON-	PRP$
cord-023417-by18aczt	479	2	observation	observation	NN
cord-023417-by18aczt	479	3	that	that	IN
cord-023417-by18aczt	479	4	C4-deficient	c4-deficient	NN
cord-023417-by18aczt	479	5	,	,	,
cord-023417-by18aczt	479	6	SLE	sle	NN
cord-023417-by18aczt	479	7	-	-	HYPH
cord-023417-by18aczt	479	8	susceptible	susceptible	JJ
cord-023417-by18aczt	479	9	mice	mouse	NNS
cord-023417-by18aczt	479	10	demonstrate	demonstrate	VBP
cord-023417-by18aczt	479	11	an	an	DT
cord-023417-by18aczt	479	12	increased	increase	VBN
cord-023417-by18aczt	479	13	spontaneous	spontaneous	JJ
cord-023417-by18aczt	479	14	IFN	IFN	NNP
cord-023417-by18aczt	479	15	-	-	:
cord-023417-by18aczt	479	16	a	a	DT
cord-023417-by18aczt	479	17	production	production	NN
cord-023417-by18aczt	479	18	by	by	IN
cord-023417-by18aczt	479	19	splenic	splenic	JJ
cord-023417-by18aczt	479	20	CD11b	CD11b	NNPS
cord-023417-by18aczt	479	21	þ	þ	NNP
cord-023417-by18aczt	479	22	marginal	marginal	JJ
cord-023417-by18aczt	479	23	zone	zone	NN
cord-023417-by18aczt	479	24	macrophages	macrophage	NNS
cord-023417-by18aczt	479	25	could	could	MD
cord-023417-by18aczt	479	26	be	be	VB
cord-023417-by18aczt	479	27	an	an	DT
cord-023417-by18aczt	479	28	early	early	JJ
cord-023417-by18aczt	479	29	sign	sign	NN
cord-023417-by18aczt	479	30	and	and	CC
cord-023417-by18aczt	479	31	a	a	DT
cord-023417-by18aczt	479	32	trigger	trigger	NN
cord-023417-by18aczt	479	33	for	for	IN
cord-023417-by18aczt	479	34	the	the	DT
cord-023417-by18aczt	479	35	development	development	NN
cord-023417-by18aczt	479	36	of	of	IN
cord-023417-by18aczt	479	37	SLE	SLE	NNP
cord-023417-by18aczt	479	38	.	.	.
cord-023417-by18aczt	480	1	This	this	DT
cord-023417-by18aczt	480	2	is	be	VBZ
cord-023417-by18aczt	480	3	supported	support	VBN
cord-023417-by18aczt	480	4	by	by	IN
cord-023417-by18aczt	480	5	the	the	DT
cord-023417-by18aczt	480	6	fact	fact	NN
cord-023417-by18aczt	480	7	that	that	IN
cord-023417-by18aczt	480	8	the	the	DT
cord-023417-by18aczt	480	9	absence	absence	NN
cord-023417-by18aczt	480	10	of	of	IN
cord-023417-by18aczt	480	11	C3	C3	NNP
cord-023417-by18aczt	480	12	is	be	VBZ
cord-023417-by18aczt	480	13	not	not	RB
cord-023417-by18aczt	480	14	a	a	DT
cord-023417-by18aczt	480	15	predisposing	predisposing	JJ
cord-023417-by18aczt	480	16	factor	factor	NN
cord-023417-by18aczt	480	17	for	for	IN
cord-023417-by18aczt	480	18	SLE	SLE	NNP
cord-023417-by18aczt	480	19	and	and	CC
cord-023417-by18aczt	480	20	our	-PRON-	PRP$
cord-023417-by18aczt	480	21	observation	observation	NN
cord-023417-by18aczt	480	22	that	that	IN
cord-023417-by18aczt	480	23	C3	c3	NN
cord-023417-by18aczt	480	24	def	def	NN
cord-023417-by18aczt	480	25	.	.	.
cord-023417-by18aczt	481	1	animals	animal	NNS
cord-023417-by18aczt	481	2	display	display	VBP
cord-023417-by18aczt	481	3	low	low	JJ
cord-023417-by18aczt	481	4	levels	level	NNS
cord-023417-by18aczt	481	5	of	of	IN
cord-023417-by18aczt	481	6	IFN	IFN	NNP
cord-023417-by18aczt	481	7	-	-	:
cord-023417-by18aczt	481	8	a	a	DT
cord-023417-by18aczt	481	9	mRNA	mrna	NN
cord-023417-by18aczt	481	10	.	.	.
cord-023417-by18aczt	481	11	 	 	_SP
cord-023417-by18aczt	482	1	200	200	CD
cord-023417-by18aczt	482	2	-	-	SYM
cord-023417-by18aczt	482	3	400	400	CD
cord-023417-by18aczt	482	4	million	million	CD
cord-023417-by18aczt	482	5	people	people	NNS
cord-023417-by18aczt	482	6	worldwide	worldwide	RB
cord-023417-by18aczt	482	7	and	and	CC
cord-023417-by18aczt	482	8	represents	represent	VBZ
cord-023417-by18aczt	482	9	one	one	CD
cord-023417-by18aczt	482	10	of	of	IN
cord-023417-by18aczt	482	11	the	the	DT
cord-023417-by18aczt	482	12	leading	lead	VBG
cord-023417-by18aczt	482	13	causes	cause	NNS
cord-023417-by18aczt	482	14	for	for	IN
cord-023417-by18aczt	482	15	liver	liver	NN
cord-023417-by18aczt	482	16	cirrhosis	cirrhosis	NN
cord-023417-by18aczt	482	17	and	and	CC
cord-023417-by18aczt	482	18	hepatocellular	hepatocellular	JJ
cord-023417-by18aczt	482	19	carcinoma	carcinoma	NN
cord-023417-by18aczt	482	20	.	.	.
cord-023417-by18aczt	483	1	Control	control	NN
cord-023417-by18aczt	483	2	over	over	IN
cord-023417-by18aczt	483	3	the	the	DT
cord-023417-by18aczt	483	4	HBV	HBV	NNP
cord-023417-by18aczt	483	5	infection	infection	NN
cord-023417-by18aczt	483	6	is	be	VBZ
cord-023417-by18aczt	483	7	achieved	achieve	VBN
cord-023417-by18aczt	483	8	mainly	mainly	RB
cord-023417-by18aczt	483	9	by	by	IN
cord-023417-by18aczt	483	10	vaccination	vaccination	NN
cord-023417-by18aczt	483	11	with	with	IN
cord-023417-by18aczt	483	12	Hepatitis	Hepatitis	NNP
cord-023417-by18aczt	483	13	B	B	NNP
cord-023417-by18aczt	483	14	surface	surface	NN
cord-023417-by18aczt	483	15	antigen	antigen	NN
cord-023417-by18aczt	483	16	(	(	-LRB-
cord-023417-by18aczt	483	17	HBsAg	hbsag	ADD
cord-023417-by18aczt	483	18	)	)	-RRB-
cord-023417-by18aczt	483	19	.	.	.
cord-023417-by18aczt	484	1	HBsAg	HBsAg	NNP
cord-023417-by18aczt	484	2	contains	contain	VBZ
cord-023417-by18aczt	484	3	N	n	CD
cord-023417-by18aczt	484	4	-	-	HYPH
cord-023417-by18aczt	484	5	linked	link	VBN
cord-023417-by18aczt	484	6	glycosylation	glycosylation	NN
cord-023417-by18aczt	484	7	side	side	NN
cord-023417-by18aczt	484	8	and	and	CC
cord-023417-by18aczt	484	9	is	be	VBZ
cord-023417-by18aczt	484	10	recognized	recognize	VBN
cord-023417-by18aczt	484	11	by	by	IN
cord-023417-by18aczt	484	12	both	both	DT
cord-023417-by18aczt	484	13	MBL	MBL	NNP
cord-023417-by18aczt	484	14	-	-	HYPH
cord-023417-by18aczt	484	15	A	A	NNP
cord-023417-by18aczt	484	16	and	and	CC
cord-023417-by18aczt	484	17	MBL	MBL	NNP
cord-023417-by18aczt	484	18	-	-	HYPH
cord-023417-by18aczt	484	19	C	C	NNP
cord-023417-by18aczt	484	20	in	in	IN
cord-023417-by18aczt	484	21	a	a	DT
cord-023417-by18aczt	484	22	Cadependent	Cadependent	NNP
cord-023417-by18aczt	484	23	manner	manner	NN
cord-023417-by18aczt	484	24	.	.	.
cord-023417-by18aczt	485	1	HbsAg	HbsAg	NNP
cord-023417-by18aczt	485	2	-	-	HYPH
cord-023417-by18aczt	485	3	MBL	MBL	NNP
cord-023417-by18aczt	485	4	complexes	complex	NNS
cord-023417-by18aczt	485	5	activate	activate	VBP
cord-023417-by18aczt	485	6	complement	complement	NN
cord-023417-by18aczt	485	7	and	and	CC
cord-023417-by18aczt	485	8	may	may	MD
cord-023417-by18aczt	485	9	thus	thus	RB
cord-023417-by18aczt	485	10	affect	affect	VB
cord-023417-by18aczt	485	11	humoural	humoural	JJ
cord-023417-by18aczt	485	12	immunity	immunity	NN
cord-023417-by18aczt	485	13	.	.	.
cord-023417-by18aczt	486	1	To	to	TO
cord-023417-by18aczt	486	2	investigate	investigate	VB
cord-023417-by18aczt	486	3	the	the	DT
cord-023417-by18aczt	486	4	role	role	NN
cord-023417-by18aczt	486	5	of	of	IN
cord-023417-by18aczt	486	6	MBL	MBL	NNP
cord-023417-by18aczt	486	7	in	in	IN
cord-023417-by18aczt	486	8	humoural	humoural	NNP
cord-023417-by18aczt	486	9	responses	response	NNS
cord-023417-by18aczt	486	10	to	to	IN
cord-023417-by18aczt	486	11	HBsAg	hbsag	ADD
cord-023417-by18aczt	486	12	,	,	,
cord-023417-by18aczt	486	13	we	-PRON-	PRP
cord-023417-by18aczt	486	14	immununized	immununize	VBD
cord-023417-by18aczt	486	15	mice	mouse	NNS
cord-023417-by18aczt	486	16	that	that	WDT
cord-023417-by18aczt	486	17	lack	lack	VBP
cord-023417-by18aczt	486	18	both	both	DT
cord-023417-by18aczt	486	19	MBL	MBL	NNP
cord-023417-by18aczt	486	20	-	-	HYPH
cord-023417-by18aczt	486	21	A	A	NNP
cord-023417-by18aczt	486	22	and	and	CC
cord-023417-by18aczt	486	23	MBL	MBL	NNP
cord-023417-by18aczt	486	24	-	-	HYPH
cord-023417-by18aczt	486	25	C	c	NN
cord-023417-by18aczt	486	26	proteins	protein	NNS
cord-023417-by18aczt	486	27	with	with	IN
cord-023417-by18aczt	486	28	soluble	soluble	JJ
cord-023417-by18aczt	486	29	HBsAg	hbsag	ADD
cord-023417-by18aczt	486	30	.	.	.
cord-023417-by18aczt	487	1	It	-PRON-	PRP
cord-023417-by18aczt	487	2	has	have	VBZ
cord-023417-by18aczt	487	3	been	be	VBN
cord-023417-by18aczt	487	4	shown	show	VBN
cord-023417-by18aczt	487	5	that	that	IN
cord-023417-by18aczt	487	6	deficiencies	deficiency	NNS
cord-023417-by18aczt	487	7	in	in	IN
cord-023417-by18aczt	487	8	other	other	JJ
cord-023417-by18aczt	487	9	complement	complement	NN
cord-023417-by18aczt	487	10	components	component	NNS
cord-023417-by18aczt	487	11	like	like	IN
cord-023417-by18aczt	487	12	C1q	C1q	NNP
cord-023417-by18aczt	487	13	,	,	,
cord-023417-by18aczt	487	14	C4	C4	NNP
cord-023417-by18aczt	487	15	and	and	CC
cord-023417-by18aczt	487	16	C3	c3	NN
cord-023417-by18aczt	487	17	result	result	NN
cord-023417-by18aczt	487	18	in	in	IN
cord-023417-by18aczt	487	19	decreased	decrease	VBN
cord-023417-by18aczt	487	20	antibody	antibody	NN
cord-023417-by18aczt	487	21	responses	response	NNS
cord-023417-by18aczt	487	22	.	.	.
cord-023417-by18aczt	488	1	However	however	RB
cord-023417-by18aczt	488	2	,	,	,
cord-023417-by18aczt	488	3	MBL	MBL	NNP
cord-023417-by18aczt	488	4	double	double	JJ
cord-023417-by18aczt	488	5	KO	KO	NNP
cord-023417-by18aczt	488	6	animals	animal	NNS
cord-023417-by18aczt	488	7	mounted	mount	VBD
cord-023417-by18aczt	488	8	dramatically	dramatically	RB
cord-023417-by18aczt	488	9	increased	increase	VBN
cord-023417-by18aczt	488	10	humoural	humoural	JJ
cord-023417-by18aczt	488	11	responses	response	NNS
cord-023417-by18aczt	488	12	.	.	.
cord-023417-by18aczt	489	1	After	after	IN
cord-023417-by18aczt	489	2	priming	prime	VBG
cord-023417-by18aczt	489	3	,	,	,
cord-023417-by18aczt	489	4	MBL	MBL	NNP
cord-023417-by18aczt	489	5	double	double	JJ
cord-023417-by18aczt	489	6	KOs	KOs	NNP
cord-023417-by18aczt	489	7	mounted	mount	VBD
cord-023417-by18aczt	489	8	HbsAg	HbsAg	NNP
cord-023417-by18aczt	489	9	-	-	HYPH
cord-023417-by18aczt	489	10	specific	specific	JJ
cord-023417-by18aczt	489	11	IgM	IgM	NNP
cord-023417-by18aczt	489	12	responses	response	NNS
cord-023417-by18aczt	489	13	,	,	,
cord-023417-by18aczt	489	14	which	which	WDT
cord-023417-by18aczt	489	15	were	be	VBD
cord-023417-by18aczt	489	16	threefold	threefold	RB
cord-023417-by18aczt	489	17	higher	high	JJR
cord-023417-by18aczt	489	18	than	than	IN
cord-023417-by18aczt	489	19	WT	WT	NNP
cord-023417-by18aczt	489	20	controls	control	NNS
cord-023417-by18aczt	489	21	.	.	.
cord-023417-by18aczt	490	1	After	after	IN
cord-023417-by18aczt	490	2	boosting	boost	VBG
cord-023417-by18aczt	490	3	the	the	DT
cord-023417-by18aczt	490	4	HBsAg	hbsag	XX
cord-023417-by18aczt	490	5	,	,	,
cord-023417-by18aczt	490	6	total	total	JJ
cord-023417-by18aczt	490	7	IgG	igg	NN
cord-023417-by18aczt	490	8	was	be	VBD
cord-023417-by18aczt	490	9	10-fold	10-fold	JJ
cord-023417-by18aczt	490	10	higher	high	JJR
cord-023417-by18aczt	490	11	in	in	IN
cord-023417-by18aczt	490	12	MBL	MBL	NNP
cord-023417-by18aczt	490	13	KO	KO	NNP
cord-023417-by18aczt	490	14	than	than	IN
cord-023417-by18aczt	490	15	in	in	IN
cord-023417-by18aczt	490	16	WT	WT	NNP
cord-023417-by18aczt	490	17	control	control	NN
cord-023417-by18aczt	490	18	animals	animal	NNS
cord-023417-by18aczt	490	19	.	.	.
cord-023417-by18aczt	491	1	Similar	similar	JJ
cord-023417-by18aczt	491	2	to	to	IN
cord-023417-by18aczt	491	3	the	the	DT
cord-023417-by18aczt	491	4	response	response	NN
cord-023417-by18aczt	491	5	to	to	TO
cord-023417-by18aczt	491	6	HbsAg	HbsAg	NNP
cord-023417-by18aczt	491	7	,	,	,
cord-023417-by18aczt	491	8	other	other	JJ
cord-023417-by18aczt	491	9	glycosylated	glycosylated	JJ
cord-023417-by18aczt	491	10	soluble	soluble	JJ
cord-023417-by18aczt	491	11	antigens	antigen	NNS
cord-023417-by18aczt	491	12	(	(	-LRB-
cord-023417-by18aczt	491	13	e.g.	e.g.	IN
cord-023417-by18aczt	491	14	invertase	invertase	NNP
cord-023417-by18aczt	491	15	)	)	-RRB-
cord-023417-by18aczt	491	16	induced	induce	VBN
cord-023417-by18aczt	491	17	better	well	JJR
cord-023417-by18aczt	491	18	humoural	humoural	JJ
cord-023417-by18aczt	491	19	responses	response	NNS
cord-023417-by18aczt	491	20	in	in	IN
cord-023417-by18aczt	491	21	MBL	MBL	NNP
cord-023417-by18aczt	491	22	double	double	JJ
cord-023417-by18aczt	491	23	KO	KO	NNP
cord-023417-by18aczt	491	24	animals	animal	NNS
cord-023417-by18aczt	491	25	,	,	,
cord-023417-by18aczt	491	26	suggesting	suggest	VBG
cord-023417-by18aczt	491	27	that	that	IN
cord-023417-by18aczt	491	28	MBL	MBL	NNP
cord-023417-by18aczt	491	29	plays	play	VBZ
cord-023417-by18aczt	491	30	an	an	DT
cord-023417-by18aczt	491	31	important	important	JJ
cord-023417-by18aczt	491	32	role	role	NN
cord-023417-by18aczt	491	33	in	in	IN
cord-023417-by18aczt	491	34	a	a	DT
cord-023417-by18aczt	491	35	negative	negative	JJ
cord-023417-by18aczt	491	36	feedback	feedback	NN
cord-023417-by18aczt	491	37	regulation	regulation	NN
cord-023417-by18aczt	491	38	of	of	IN
cord-023417-by18aczt	491	39	adaptive	adaptive	JJ
cord-023417-by18aczt	491	40	immunity	immunity	NN
cord-023417-by18aczt	491	41	.	.	.
cord-023417-by18aczt	492	1	Reconstitution	reconstitution	NN
cord-023417-by18aczt	492	2	experiments	experiment	NNS
cord-023417-by18aczt	492	3	with	with	IN
cord-023417-by18aczt	492	4	rMBL	rMBL	NNS
cord-023417-by18aczt	492	5	partially	partially	RB
cord-023417-by18aczt	492	6	rescued	rescue	VBD
cord-023417-by18aczt	492	7	the	the	DT
cord-023417-by18aczt	492	8	KO	KO	NNP
cord-023417-by18aczt	492	9	phenotype	phenotype	NN
cord-023417-by18aczt	492	10	.	.	.
cord-023417-by18aczt	493	1	We	-PRON-	PRP
cord-023417-by18aczt	493	2	propose	propose	VBP
cord-023417-by18aczt	493	3	that	that	IN
cord-023417-by18aczt	493	4	the	the	DT
cord-023417-by18aczt	493	5	clearance	clearance	NN
cord-023417-by18aczt	493	6	of	of	IN
cord-023417-by18aczt	493	7	glycoprotein	glycoprotein	NN
cord-023417-by18aczt	493	8	antigens	antigen	NNS
cord-023417-by18aczt	493	9	in	in	IN
cord-023417-by18aczt	493	10	MBL	MBL	NNP
cord-023417-by18aczt	493	11	KO	KO	NNP
cord-023417-by18aczt	493	12	is	be	VBZ
cord-023417-by18aczt	493	13	handled	handle	VBN
cord-023417-by18aczt	493	14	differently	differently	RB
cord-023417-by18aczt	493	15	from	from	IN
cord-023417-by18aczt	493	16	the	the	DT
cord-023417-by18aczt	493	17	WT	WT	NNP
cord-023417-by18aczt	493	18	,	,	,
cord-023417-by18aczt	493	19	resulting	result	VBG
cord-023417-by18aczt	493	20	in	in	IN
cord-023417-by18aczt	493	21	better	well	JJR
cord-023417-by18aczt	493	22	stimulation	stimulation	NN
cord-023417-by18aczt	493	23	of	of	IN
cord-023417-by18aczt	493	24	humoural	humoural	JJ
cord-023417-by18aczt	493	25	responses	response	NNS
cord-023417-by18aczt	493	26	.	.	.
cord-023417-by18aczt	494	1	Alternatively	alternatively	RB
cord-023417-by18aczt	494	2	,	,	,
cord-023417-by18aczt	494	3	glycoprotein	glycoprotein	NN
cord-023417-by18aczt	494	4	-	-	:
cord-023417-by18aczt	494	5	Ag	Ag	NNP
cord-023417-by18aczt	494	6	-	-	HYPH
cord-023417-by18aczt	494	7	MBL	MBL	NNP
cord-023417-by18aczt	494	8	-	-	HYPH
cord-023417-by18aczt	494	9	rich	rich	JJ
cord-023417-by18aczt	494	10	complexes	complex	NNS
cord-023417-by18aczt	494	11	inhibit	inhibit	VBP
cord-023417-by18aczt	494	12	B	b	NN
cord-023417-by18aczt	494	13	-	-	HYPH
cord-023417-by18aczt	494	14	cell	cell	NN
cord-023417-by18aczt	494	15	responsiveness	responsiveness	NN
cord-023417-by18aczt	494	16	via	via	IN
cord-023417-by18aczt	494	17	putative	putative	JJ
cord-023417-by18aczt	494	18	MBL	MBL	NNP
cord-023417-by18aczt	494	19	receptors	receptor	NNS
cord-023417-by18aczt	494	20	.	.	.
cord-023417-by18aczt	495	1	The	the	DT
cord-023417-by18aczt	495	2	complement	complement	NN
cord-023417-by18aczt	495	3	system	system	NN
cord-023417-by18aczt	495	4	is	be	VBZ
cord-023417-by18aczt	495	5	an	an	DT
cord-023417-by18aczt	495	6	important	important	JJ
cord-023417-by18aczt	495	7	part	part	NN
cord-023417-by18aczt	495	8	of	of	IN
cord-023417-by18aczt	495	9	the	the	DT
cord-023417-by18aczt	495	10	innate	innate	JJ
cord-023417-by18aczt	495	11	immune	immune	JJ
cord-023417-by18aczt	495	12	system	system	NN
cord-023417-by18aczt	495	13	.	.	.
cord-023417-by18aczt	496	1	The	the	DT
cord-023417-by18aczt	496	2	activation	activation	NN
cord-023417-by18aczt	496	3	of	of	IN
cord-023417-by18aczt	496	4	complement	complement	NN
cord-023417-by18aczt	496	5	proceeds	proceed	VBZ
cord-023417-by18aczt	496	6	through	through	IN
cord-023417-by18aczt	496	7	three	three	CD
cord-023417-by18aczt	496	8	different	different	JJ
cord-023417-by18aczt	496	9	pathways	pathway	NNS
cord-023417-by18aczt	496	10	that	that	WDT
cord-023417-by18aczt	496	11	converge	converge	VBP
cord-023417-by18aczt	496	12	in	in	IN
cord-023417-by18aczt	496	13	the	the	DT
cord-023417-by18aczt	496	14	generation	generation	NN
cord-023417-by18aczt	496	15	of	of	IN
cord-023417-by18aczt	496	16	C3-activating	c3-activate	VBG
cord-023417-by18aczt	496	17	enzyme	enzyme	NN
cord-023417-by18aczt	496	18	complexes	complex	NNS
cord-023417-by18aczt	496	19	.	.	.
cord-023417-by18aczt	497	1	Complement	complement	JJ
cord-023417-by18aczt	497	2	activation	activation	NN
cord-023417-by18aczt	497	3	via	via	IN
cord-023417-by18aczt	497	4	the	the	DT
cord-023417-by18aczt	497	5	lectin	lectin	NN
cord-023417-by18aczt	497	6	pathway	pathway	NN
cord-023417-by18aczt	497	7	is	be	VBZ
cord-023417-by18aczt	497	8	initiated	initiate	VBN
cord-023417-by18aczt	497	9	when	when	WRB
cord-023417-by18aczt	497	10	recognition	recognition	NN
cord-023417-by18aczt	497	11	molecules	molecule	NNS
cord-023417-by18aczt	497	12	,	,	,
cord-023417-by18aczt	497	13	mannan	mannan	NN
cord-023417-by18aczt	497	14	-	-	HYPH
cord-023417-by18aczt	497	15	binding	bind	VBG
cord-023417-by18aczt	497	16	lectin	lectin	NN
cord-023417-by18aczt	497	17	(	(	-LRB-
cord-023417-by18aczt	497	18	MBL	MBL	NNP
cord-023417-by18aczt	497	19	)	)	-RRB-
cord-023417-by18aczt	497	20	or	or	CC
cord-023417-by18aczt	497	21	ficolin	ficolin	NN
cord-023417-by18aczt	497	22	,	,	,
cord-023417-by18aczt	497	23	bind	bind	VB
cord-023417-by18aczt	497	24	to	to	IN
cord-023417-by18aczt	497	25	carbohydrate	carbohydrate	NN
cord-023417-by18aczt	497	26	structures	structure	NNS
cord-023417-by18aczt	497	27	characteristic	characteristic	JJ
cord-023417-by18aczt	497	28	for	for	IN
cord-023417-by18aczt	497	29	microbial	microbial	JJ
cord-023417-by18aczt	497	30	surfaces	surface	NNS
cord-023417-by18aczt	497	31	.	.	.
cord-023417-by18aczt	498	1	In	in	IN
cord-023417-by18aczt	498	2	the	the	DT
cord-023417-by18aczt	498	3	circulation	circulation	NN
cord-023417-by18aczt	498	4	,	,	,
cord-023417-by18aczt	498	5	MBL	MBL	NNP
cord-023417-by18aczt	498	6	and	and	CC
cord-023417-by18aczt	498	7	ficolins	ficolin	NNS
cord-023417-by18aczt	498	8	are	be	VBP
cord-023417-by18aczt	498	9	found	find	VBN
cord-023417-by18aczt	498	10	in	in	IN
cord-023417-by18aczt	498	11	association	association	NN
cord-023417-by18aczt	498	12	with	with	IN
cord-023417-by18aczt	498	13	three	three	CD
cord-023417-by18aczt	498	14	structurally	structurally	RB
cord-023417-by18aczt	498	15	related	relate	VBN
cord-023417-by18aczt	498	16	MBLassociated	mblassociated	JJ
cord-023417-by18aczt	498	17	serine	serine	NN
cord-023417-by18aczt	498	18	proteases	protease	NNS
cord-023417-by18aczt	498	19	(	(	-LRB-
cord-023417-by18aczt	498	20	MASP)-1	masp)-1	NN
cord-023417-by18aczt	498	21	,	,	,
cord-023417-by18aczt	498	22	-2	-2	NNP
cord-023417-by18aczt	498	23	and	and	CC
cord-023417-by18aczt	498	24	-3	-3	NNP
cord-023417-by18aczt	498	25	and	and	CC
cord-023417-by18aczt	498	26	a	a	DT
cord-023417-by18aczt	498	27	small	small	JJ
cord-023417-by18aczt	498	28	,	,	,
cord-023417-by18aczt	498	29	nonenzymatic	nonenzymatic	JJ
cord-023417-by18aczt	498	30	component	component	NN
cord-023417-by18aczt	498	31	,	,	,
cord-023417-by18aczt	498	32	MAp19	MAp19	NNP
cord-023417-by18aczt	498	33	.	.	.
cord-023417-by18aczt	499	1	MASP-2	MASP-2	NNP
cord-023417-by18aczt	499	2	has	have	VBZ
cord-023417-by18aczt	499	3	been	be	VBN
cord-023417-by18aczt	499	4	shown	show	VBN
cord-023417-by18aczt	499	5	to	to	TO
cord-023417-by18aczt	499	6	elicit	elicit	VB
cord-023417-by18aczt	499	7	complement	complement	NN
cord-023417-by18aczt	499	8	activation	activation	NN
cord-023417-by18aczt	499	9	through	through	IN
cord-023417-by18aczt	499	10	the	the	DT
cord-023417-by18aczt	499	11	sequential	sequential	JJ
cord-023417-by18aczt	499	12	proteolytic	proteolytic	JJ
cord-023417-by18aczt	499	13	cleavage	cleavage	NN
cord-023417-by18aczt	499	14	of	of	IN
cord-023417-by18aczt	499	15	C4	c4	NN
cord-023417-by18aczt	499	16	and	and	CC
cord-023417-by18aczt	499	17	C2	C2	NNP
cord-023417-by18aczt	499	18	upon	upon	IN
cord-023417-by18aczt	499	19	binding	bind	VBG
cord-023417-by18aczt	499	20	of	of	IN
cord-023417-by18aczt	499	21	MBL	MBL	NNP
cord-023417-by18aczt	499	22	/	/	SYM
cord-023417-by18aczt	499	23	MASP-2	masp-2	NN
cord-023417-by18aczt	499	24	complexes	complex	NNS
cord-023417-by18aczt	499	25	to	to	IN
cord-023417-by18aczt	499	26	microbial	microbial	JJ
cord-023417-by18aczt	499	27	surfaces	surface	NNS
cord-023417-by18aczt	499	28	.	.	.
cord-023417-by18aczt	500	1	We	-PRON-	PRP
cord-023417-by18aczt	500	2	have	have	VBP
cord-023417-by18aczt	500	3	recently	recently	RB
cord-023417-by18aczt	500	4	uncovered	uncover	VBN
cord-023417-by18aczt	500	5	a	a	DT
cord-023417-by18aczt	500	6	polymorphism	polymorphism	NN
cord-023417-by18aczt	500	7	in	in	IN
cord-023417-by18aczt	500	8	the	the	DT
cord-023417-by18aczt	500	9	MASP-2	MASP-2	NNP
cord-023417-by18aczt	500	10	/	/	SYM
cord-023417-by18aczt	500	11	MAp19	map19	NN
cord-023417-by18aczt	500	12	gene	gene	NN
cord-023417-by18aczt	500	13	in	in	IN
cord-023417-by18aczt	500	14	a	a	DT
cord-023417-by18aczt	500	15	patient	patient	NN
cord-023417-by18aczt	500	16	shown	show	VBN
cord-023417-by18aczt	500	17	to	to	TO
cord-023417-by18aczt	500	18	be	be	VB
cord-023417-by18aczt	500	19	deficient	deficient	JJ
cord-023417-by18aczt	500	20	in	in	IN
cord-023417-by18aczt	500	21	the	the	DT
cord-023417-by18aczt	500	22	lectin	lectin	NN
cord-023417-by18aczt	500	23	pathway	pathway	NN
cord-023417-by18aczt	500	24	of	of	IN
cord-023417-by18aczt	500	25	complement	complement	JJ
cord-023417-by18aczt	500	26	activation	activation	NN
cord-023417-by18aczt	500	27	.	.	.
cord-023417-by18aczt	501	1	The	the	DT
cord-023417-by18aczt	501	2	polymorphism	polymorphism	NN
cord-023417-by18aczt	501	3	results	result	VBZ
cord-023417-by18aczt	501	4	in	in	IN
cord-023417-by18aczt	501	5	a	a	DT
cord-023417-by18aczt	501	6	single	single	JJ
cord-023417-by18aczt	501	7	amino	amino	NN
cord-023417-by18aczt	501	8	acid	acid	NN
cord-023417-by18aczt	501	9	substitution	substitution	NN
cord-023417-by18aczt	501	10	in	in	IN
cord-023417-by18aczt	501	11	the	the	DT
cord-023417-by18aczt	501	12	N	n	CD
cord-023417-by18aczt	501	13	-	-	HYPH
cord-023417-by18aczt	501	14	terminal	terminal	JJ
cord-023417-by18aczt	501	15	part	part	NN
cord-023417-by18aczt	501	16	of	of	IN
cord-023417-by18aczt	501	17	the	the	DT
cord-023417-by18aczt	501	18	MASP-2	MASP-2	NNP
cord-023417-by18aczt	501	19	protein	protein	NN
cord-023417-by18aczt	501	20	.	.	.
cord-023417-by18aczt	502	1	Recombinant	recombinant	JJ
cord-023417-by18aczt	502	2	wildtype	wildtype	NN
cord-023417-by18aczt	502	3	MASP-2	MASP-2	NNP
cord-023417-by18aczt	502	4	and	and	CC
cord-023417-by18aczt	502	5	MASP-2	MASP-2	NNP
cord-023417-by18aczt	502	6	containing	contain	VBG
cord-023417-by18aczt	502	7	the	the	DT
cord-023417-by18aczt	502	8	amino	amino	NN
cord-023417-by18aczt	502	9	acid	acid	NN
cord-023417-by18aczt	502	10	substitution	substitution	NN
cord-023417-by18aczt	502	11	in	in	IN
cord-023417-by18aczt	502	12	question	question	NN
cord-023417-by18aczt	502	13	was	be	VBD
cord-023417-by18aczt	502	14	produced	produce	VBN
cord-023417-by18aczt	502	15	,	,	,
cord-023417-by18aczt	502	16	and	and	CC
cord-023417-by18aczt	502	17	the	the	DT
cord-023417-by18aczt	502	18	ability	ability	NN
cord-023417-by18aczt	502	19	to	to	TO
cord-023417-by18aczt	502	20	activate	activate	VB
cord-023417-by18aczt	502	21	complement	complement	NN
cord-023417-by18aczt	502	22	was	be	VBD
cord-023417-by18aczt	502	23	studied	study	VBN
cord-023417-by18aczt	502	24	.	.	.
cord-023417-by18aczt	503	1	The	the	DT
cord-023417-by18aczt	503	2	mutation	mutation	NN
cord-023417-by18aczt	503	3	had	have	VBD
cord-023417-by18aczt	503	4	a	a	DT
cord-023417-by18aczt	503	5	profound	profound	JJ
cord-023417-by18aczt	503	6	impact	impact	NN
cord-023417-by18aczt	503	7	on	on	IN
cord-023417-by18aczt	503	8	MASP-2	masp-2	NN
cord-023417-by18aczt	503	9	function	function	NN
cord-023417-by18aczt	503	10	,	,	,
cord-023417-by18aczt	503	11	resulting	result	VBG
cord-023417-by18aczt	503	12	in	in	IN
cord-023417-by18aczt	503	13	the	the	DT
cord-023417-by18aczt	503	14	lack	lack	NN
cord-023417-by18aczt	503	15	of	of	IN
cord-023417-by18aczt	503	16	complement	complement	JJ
cord-023417-by18aczt	503	17	activation	activation	NN
cord-023417-by18aczt	503	18	through	through	IN
cord-023417-by18aczt	503	19	the	the	DT
cord-023417-by18aczt	503	20	lectin	lectin	NN
cord-023417-by18aczt	503	21	pathway	pathway	NN
cord-023417-by18aczt	503	22	.	.	.
cord-023417-by18aczt	504	1	ELISA	ELISA	NNP
cord-023417-by18aczt	504	2	-	-	HYPH
cord-023417-by18aczt	504	3	based	base	VBN
cord-023417-by18aczt	504	4	experiments	experiment	NNS
cord-023417-by18aczt	504	5	showed	show	VBD
cord-023417-by18aczt	504	6	that	that	IN
cord-023417-by18aczt	504	7	the	the	DT
cord-023417-by18aczt	504	8	mutation	mutation	NN
cord-023417-by18aczt	504	9	leads	lead	VBZ
cord-023417-by18aczt	504	10	to	to	IN
cord-023417-by18aczt	504	11	the	the	DT
cord-023417-by18aczt	504	12	impairment	impairment	NN
cord-023417-by18aczt	504	13	of	of	IN
cord-023417-by18aczt	504	14	complement	complement	JJ
cord-023417-by18aczt	504	15	activation	activation	NN
cord-023417-by18aczt	504	16	through	through	IN
cord-023417-by18aczt	504	17	influencing	influence	VBG
cord-023417-by18aczt	504	18	the	the	DT
cord-023417-by18aczt	504	19	binding	binding	NN
cord-023417-by18aczt	504	20	of	of	IN
cord-023417-by18aczt	504	21	MASP-2	MASP-2	NNP
cord-023417-by18aczt	504	22	to	to	IN
cord-023417-by18aczt	504	23	MBL	MBL	NNP
cord-023417-by18aczt	504	24	or	or	CC
cord-023417-by18aczt	504	25	ficolins	ficolin	NNS
cord-023417-by18aczt	504	26	.	.	.
cord-023417-by18aczt	505	1	Deficiencies	deficiency	NNS
cord-023417-by18aczt	505	2	in	in	IN
cord-023417-by18aczt	505	3	the	the	DT
cord-023417-by18aczt	505	4	lectin	lectin	NN
cord-023417-by18aczt	505	5	pathway	pathway	NN
cord-023417-by18aczt	505	6	of	of	IN
cord-023417-by18aczt	505	7	complement	complement	JJ
cord-023417-by18aczt	505	8	activation	activation	NN
cord-023417-by18aczt	505	9	have	have	VBP
cord-023417-by18aczt	505	10	so	so	RB
cord-023417-by18aczt	505	11	far	far	RB
cord-023417-by18aczt	505	12	been	be	VBN
cord-023417-by18aczt	505	13	accounted	account	VBN
cord-023417-by18aczt	505	14	for	for	IN
cord-023417-by18aczt	505	15	only	only	RB
cord-023417-by18aczt	505	16	by	by	IN
cord-023417-by18aczt	505	17	lack	lack	NN
cord-023417-by18aczt	505	18	of	of	IN
cord-023417-by18aczt	505	19	functional	functional	JJ
cord-023417-by18aczt	505	20	MBL	MBL	NNS
cord-023417-by18aczt	505	21	.	.	.
cord-023417-by18aczt	506	1	The	the	DT
cord-023417-by18aczt	506	2	mutation	mutation	NN
cord-023417-by18aczt	506	3	described	describe	VBN
cord-023417-by18aczt	506	4	above	above	RB
cord-023417-by18aczt	506	5	is	be	VBZ
cord-023417-by18aczt	506	6	the	the	DT
cord-023417-by18aczt	506	7	first	first	JJ
cord-023417-by18aczt	506	8	defect	defect	NN
cord-023417-by18aczt	506	9	described	describe	VBN
cord-023417-by18aczt	506	10	affecting	affect	VBG
cord-023417-by18aczt	506	11	both	both	DT
cord-023417-by18aczt	506	12	activation	activation	NN
cord-023417-by18aczt	506	13	through	through	IN
cord-023417-by18aczt	506	14	MBL	MBL	NNP
cord-023417-by18aczt	506	15	and	and	CC
cord-023417-by18aczt	506	16	the	the	DT
cord-023417-by18aczt	506	17	ficolins	ficolin	NNS
cord-023417-by18aczt	506	18	.	.	.
cord-023417-by18aczt	506	19	..................................................................................................................................................................................................	..................................................................................................................................................................................................	.
cord-023417-by18aczt	507	1	Th1	Th1	NNP
cord-023417-by18aczt	507	2	,	,	,
cord-023417-by18aczt	507	3	Th2	Th2	NNP
cord-023417-by18aczt	507	4	and	and	CC
cord-023417-by18aczt	507	5	Treg	Treg	NNP
cord-023417-by18aczt	507	6	cell	cell	NN
cord-023417-by18aczt	507	7	balance	balance	NN
cord-023417-by18aczt	507	8	.	.	.
cord-023417-by18aczt	508	1	DCs	DCs	NNP
cord-023417-by18aczt	508	2	are	be	VBP
cord-023417-by18aczt	508	3	present	present	JJ
cord-023417-by18aczt	508	4	in	in	IN
cord-023417-by18aczt	508	5	the	the	DT
cord-023417-by18aczt	508	6	gut	gut	NN
cord-023417-by18aczt	508	7	mucosa	mucosa	NN
cord-023417-by18aczt	508	8	and	and	CC
cord-023417-by18aczt	508	9	may	may	MD
cord-023417-by18aczt	508	10	thus	thus	RB
cord-023417-by18aczt	508	11	be	be	VB
cord-023417-by18aczt	508	12	target	target	NN
cord-023417-by18aczt	508	13	for	for	IN
cord-023417-by18aczt	508	14	modulation	modulation	NN
cord-023417-by18aczt	508	15	by	by	IN
cord-023417-by18aczt	508	16	gut	gut	NN
cord-023417-by18aczt	508	17	microbes	microbe	NNS
cord-023417-by18aczt	508	18	,	,	,
cord-023417-by18aczt	508	19	including	include	VBG
cord-023417-by18aczt	508	20	ingested	ingest	VBN
cord-023417-by18aczt	508	21	probiotics	probiotic	NNS
cord-023417-by18aczt	508	22	.	.	.
cord-023417-by18aczt	509	1	Here	here	RB
cord-023417-by18aczt	509	2	,	,	,
cord-023417-by18aczt	509	3	we	-PRON-	PRP
cord-023417-by18aczt	509	4	tested	test	VBD
cord-023417-by18aczt	509	5	the	the	DT
cord-023417-by18aczt	509	6	hypothesis	hypothesis	NN
cord-023417-by18aczt	509	7	that	that	WDT
cord-023417-by18aczt	509	8	species	specie	NNS
cord-023417-by18aczt	509	9	of	of	IN
cord-023417-by18aczt	509	10	lactic	lactic	JJ
cord-023417-by18aczt	509	11	acid	acid	NN
cord-023417-by18aczt	509	12	bacteria	bacteria	NNS
cord-023417-by18aczt	509	13	,	,	,
cord-023417-by18aczt	509	14	important	important	JJ
cord-023417-by18aczt	509	15	members	member	NNS
cord-023417-by18aczt	509	16	of	of	IN
cord-023417-by18aczt	509	17	the	the	DT
cord-023417-by18aczt	509	18	gut	gut	NN
cord-023417-by18aczt	509	19	flora	flora	NNS
cord-023417-by18aczt	509	20	,	,	,
cord-023417-by18aczt	509	21	differentially	differentially	RB
cord-023417-by18aczt	509	22	activate	activate	VB
cord-023417-by18aczt	509	23	DC	DC	NNP
cord-023417-by18aczt	509	24	.	.	.
cord-023417-by18aczt	510	1	A	a	DT
cord-023417-by18aczt	510	2	large	large	JJ
cord-023417-by18aczt	510	3	panel	panel	NN
cord-023417-by18aczt	510	4	of	of	IN
cord-023417-by18aczt	510	5	human	human	JJ
cord-023417-by18aczt	510	6	gut	gut	NN
cord-023417-by18aczt	510	7	-	-	HYPH
cord-023417-by18aczt	510	8	derived	derive	VBN
cord-023417-by18aczt	510	9	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	510	10	and	and	CC
cord-023417-by18aczt	510	11	Bifidobacterium	bifidobacterium	NN
cord-023417-by18aczt	510	12	spp	spp	NNS
cord-023417-by18aczt	510	13	.	.	.
cord-023417-by18aczt	511	1	was	be	VBD
cord-023417-by18aczt	511	2	screened	screen	VBN
cord-023417-by18aczt	511	3	for	for	IN
cord-023417-by18aczt	511	4	DC	DC	NNP
cord-023417-by18aczt	511	5	-	-	HYPH
cord-023417-by18aczt	511	6	polarizing	polarize	VBG
cord-023417-by18aczt	511	7	capacity	capacity	NN
cord-023417-by18aczt	511	8	by	by	IN
cord-023417-by18aczt	511	9	exposing	expose	VBG
cord-023417-by18aczt	511	10	bone	bone	NN
cord-023417-by18aczt	511	11	marrow	marrow	NN
cord-023417-by18aczt	511	12	-	-	HYPH
cord-023417-by18aczt	511	13	derived	derive	VBN
cord-023417-by18aczt	511	14	murine	murine	JJ
cord-023417-by18aczt	511	15	DC	DC	NNP
cord-023417-by18aczt	511	16	to	to	IN
cord-023417-by18aczt	511	17	lethally	lethally	RB
cord-023417-by18aczt	511	18	irradiated	irradiate	VBN
cord-023417-by18aczt	511	19	bacteria	bacteria	NNS
cord-023417-by18aczt	511	20	.	.	.
cord-023417-by18aczt	512	1	Cytokines	cytokine	NNS
cord-023417-by18aczt	512	2	in	in	IN
cord-023417-by18aczt	512	3	culture	culture	NN
cord-023417-by18aczt	512	4	supernatants	supernatant	NNS
cord-023417-by18aczt	512	5	and	and	CC
cord-023417-by18aczt	512	6	DC	DC	NNP
cord-023417-by18aczt	512	7	-	-	HYPH
cord-023417-by18aczt	512	8	surface	surface	NN
cord-023417-by18aczt	512	9	maturation	maturation	NN
cord-023417-by18aczt	512	10	markers	marker	NNS
cord-023417-by18aczt	512	11	were	be	VBD
cord-023417-by18aczt	512	12	analysed	analyse	VBN
cord-023417-by18aczt	512	13	.	.	.
cord-023417-by18aczt	513	1	Substantial	substantial	JJ
cord-023417-by18aczt	513	2	differences	difference	NNS
cord-023417-by18aczt	513	3	were	be	VBD
cord-023417-by18aczt	513	4	found	find	VBN
cord-023417-by18aczt	513	5	among	among	IN
cord-023417-by18aczt	513	6	strains	strain	NNS
cord-023417-by18aczt	513	7	in	in	IN
cord-023417-by18aczt	513	8	the	the	DT
cord-023417-by18aczt	513	9	capacity	capacity	NN
cord-023417-by18aczt	513	10	to	to	TO
cord-023417-by18aczt	513	11	induce	induce	VB
cord-023417-by18aczt	513	12	interleukin-12	interleukin-12	XX
cord-023417-by18aczt	513	13	(	(	-LRB-
cord-023417-by18aczt	513	14	IL-12	IL-12	NNP
cord-023417-by18aczt	513	15	)	)	-RRB-
cord-023417-by18aczt	513	16	and	and	CC
cord-023417-by18aczt	513	17	tumour	tumour	NN
cord-023417-by18aczt	513	18	necrosis	necrosis	NN
cord-023417-by18aczt	513	19	factor	factor	NN
cord-023417-by18aczt	513	20	(	(	-LRB-
cord-023417-by18aczt	514	1	TNF)-a	TNF)-a	NNP
cord-023417-by18aczt	514	2	,	,	,
cord-023417-by18aczt	514	3	while	while	IN
cord-023417-by18aczt	514	4	the	the	DT
cord-023417-by18aczt	514	5	differences	difference	NNS
cord-023417-by18aczt	514	6	for	for	IN
cord-023417-by18aczt	514	7	IL-10	IL-10	NNP
cord-023417-by18aczt	514	8	and	and	CC
cord-023417-by18aczt	514	9	IL-6	IL-6	NNP
cord-023417-by18aczt	514	10	were	be	VBD
cord-023417-by18aczt	514	11	less	less	RBR
cord-023417-by18aczt	514	12	pronounced	pronounced	JJ
cord-023417-by18aczt	514	13	.	.	.
cord-023417-by18aczt	515	1	Bifidobacteria	Bifidobacteria	NNP
cord-023417-by18aczt	515	2	tended	tend	VBD
cord-023417-by18aczt	515	3	to	to	TO
cord-023417-by18aczt	515	4	be	be	VB
cord-023417-by18aczt	515	5	weak	weak	JJ
cord-023417-by18aczt	515	6	IL-12	IL-12	NNP
cord-023417-by18aczt	515	7	and	and	CC
cord-023417-by18aczt	515	8	TNF	TNF	NNP
cord-023417-by18aczt	515	9	-	-	,
cord-023417-by18aczt	515	10	a	a	DT
cord-023417-by18aczt	515	11	inducers	inducer	NNS
cord-023417-by18aczt	515	12	,	,	,
cord-023417-by18aczt	515	13	while	while	IN
cord-023417-by18aczt	515	14	both	both	CC
cord-023417-by18aczt	515	15	strong	strong	JJ
cord-023417-by18aczt	515	16	and	and	CC
cord-023417-by18aczt	515	17	weak	weak	JJ
cord-023417-by18aczt	515	18	IL-12	IL-12	NNP
cord-023417-by18aczt	515	19	inducers	inducer	NNS
cord-023417-by18aczt	515	20	were	be	VBD
cord-023417-by18aczt	515	21	found	find	VBN
cord-023417-by18aczt	515	22	among	among	IN
cord-023417-by18aczt	515	23	the	the	DT
cord-023417-by18aczt	515	24	strains	strain	NNS
cord-023417-by18aczt	515	25	of	of	IN
cord-023417-by18aczt	515	26	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	515	27	.	.	.
cord-023417-by18aczt	516	1	Remarkably	remarkably	RB
cord-023417-by18aczt	516	2	,	,	,
cord-023417-by18aczt	516	3	strains	strain	NNS
cord-023417-by18aczt	516	4	weak	weak	JJ
cord-023417-by18aczt	516	5	in	in	IN
cord-023417-by18aczt	516	6	IL-12	IL-12	NNP
cord-023417-by18aczt	516	7	induction	induction	NN
cord-023417-by18aczt	516	8	inhibited	inhibit	VBN
cord-023417-by18aczt	516	9	IL-12	IL-12	NNP
cord-023417-by18aczt	516	10	and	and	CC
cord-023417-by18aczt	516	11	TNF	TNF	NNP
cord-023417-by18aczt	516	12	-	-	:
cord-023417-by18aczt	516	13	a	a	DT
cord-023417-by18aczt	516	14	production	production	NN
cord-023417-by18aczt	516	15	induced	induce	VBN
cord-023417-by18aczt	516	16	by	by	IN
cord-023417-by18aczt	516	17	an	an	DT
cord-023417-by18aczt	516	18	otherwise	otherwise	RB
cord-023417-by18aczt	516	19	strong	strong	JJ
cord-023417-by18aczt	516	20	cytokine	cytokine	NN
cord-023417-by18aczt	516	21	-	-	HYPH
cord-023417-by18aczt	516	22	inducing	induce	VBG
cord-023417-by18aczt	516	23	strain	strain	NN
cord-023417-by18aczt	516	24	of	of	IN
cord-023417-by18aczt	516	25	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	516	26	casei	casei	NN
cord-023417-by18aczt	516	27	,	,	,
cord-023417-by18aczt	516	28	while	while	IN
cord-023417-by18aczt	516	29	IL-10	IL-10	NNP
cord-023417-by18aczt	516	30	production	production	NN
cord-023417-by18aczt	516	31	remained	remain	VBD
cord-023417-by18aczt	516	32	unaltered	unaltered	JJ
cord-023417-by18aczt	516	33	.	.	.
cord-023417-by18aczt	517	1	Selected	select	VBN
cord-023417-by18aczt	517	2	strains	strain	NNS
cord-023417-by18aczt	517	3	were	be	VBD
cord-023417-by18aczt	517	4	tested	test	VBN
cord-023417-by18aczt	517	5	for	for	IN
cord-023417-by18aczt	517	6	induction	induction	NN
cord-023417-by18aczt	517	7	of	of	IN
cord-023417-by18aczt	517	8	DC	DC	NNP
cord-023417-by18aczt	517	9	maturation	maturation	NN
cord-023417-by18aczt	517	10	markers	marker	NNS
cord-023417-by18aczt	517	11	.	.	.
cord-023417-by18aczt	518	1	Those	those	DT
cord-023417-by18aczt	518	2	lactobacilli	lactobacillus	NNS
cord-023417-by18aczt	518	3	with	with	IN
cord-023417-by18aczt	518	4	greatest	great	JJS
cord-023417-by18aczt	518	5	capacity	capacity	NN
cord-023417-by18aczt	518	6	to	to	TO
cord-023417-by18aczt	518	7	induce	induce	VB
cord-023417-by18aczt	518	8	IL-12	IL-12	NNP
cord-023417-by18aczt	518	9	were	be	VBD
cord-023417-by18aczt	518	10	most	most	RBS
cord-023417-by18aczt	518	11	effective	effective	JJ
cord-023417-by18aczt	518	12	in	in	IN
cord-023417-by18aczt	518	13	upregulating	upregulate	VBG
cord-023417-by18aczt	518	14	surface	surface	NN
cord-023417-by18aczt	518	15	MHC	MHC	NNP
cord-023417-by18aczt	518	16	class	class	NN
cord-023417-by18aczt	518	17	II	II	NNP
cord-023417-by18aczt	518	18	and	and	CC
cord-023417-by18aczt	518	19	CD86	CD86	NNP
cord-023417-by18aczt	518	20	.	.	.
cord-023417-by18aczt	519	1	Moreover	moreover	RB
cord-023417-by18aczt	519	2	,	,	,
cord-023417-by18aczt	519	3	L.	L.	NNP
cord-023417-by18aczt	519	4	casei	casei	NN
cord-023417-by18aczt	519	5	-	-	HYPH
cord-023417-by18aczt	519	6	induced	induce	VBN
cord-023417-by18aczt	519	7	upregulation	upregulation	NN
cord-023417-by18aczt	519	8	of	of	IN
cord-023417-by18aczt	519	9	CD86	CD86	NNP
cord-023417-by18aczt	519	10	was	be	VBD
cord-023417-by18aczt	519	11	reduced	reduce	VBN
cord-023417-by18aczt	519	12	in	in	IN
cord-023417-by18aczt	519	13	the	the	DT
cord-023417-by18aczt	519	14	presence	presence	NN
cord-023417-by18aczt	519	15	of	of	IN
cord-023417-by18aczt	519	16	a	a	DT
cord-023417-by18aczt	519	17	weak	weak	JJ
cord-023417-by18aczt	519	18	IL-12inducing	IL-12inducing	NNP
cord-023417-by18aczt	519	19	L.	L.	NNP
cord-023417-by18aczt	519	20	reuteri	reuteri	NN
cord-023417-by18aczt	519	21	.	.	.
cord-023417-by18aczt	520	1	In	in	IN
cord-023417-by18aczt	520	2	conclusion	conclusion	NN
cord-023417-by18aczt	520	3	,	,	,
cord-023417-by18aczt	520	4	human	human	JJ
cord-023417-by18aczt	520	5	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	520	6	and	and	CC
cord-023417-by18aczt	520	7	Bifidobacterium	bifidobacterium	NN
cord-023417-by18aczt	520	8	spp	spp	NNS
cord-023417-by18aczt	520	9	.	.	.
cord-023417-by18aczt	520	10	polarize	polarize	VB
cord-023417-by18aczt	520	11	differentially	differentially	RB
cord-023417-by18aczt	520	12	DC	DC	NNP
cord-023417-by18aczt	520	13	maturation	maturation	NN
cord-023417-by18aczt	520	14	.	.	.
cord-023417-by18aczt	521	1	Thus	thus	RB
cord-023417-by18aczt	521	2	,	,	,
cord-023417-by18aczt	521	3	the	the	DT
cord-023417-by18aczt	521	4	potential	potential	NN
cord-023417-by18aczt	521	5	exists	exist	VBZ
cord-023417-by18aczt	521	6	for	for	IN
cord-023417-by18aczt	521	7	Th1	th1	NN
cord-023417-by18aczt	521	8	/	/	SYM
cord-023417-by18aczt	521	9	Th2	Th2	NNP
cord-023417-by18aczt	521	10	/	/	SYM
cord-023417-by18aczt	521	11	Treg	Treg	NNP
cord-023417-by18aczt	521	12	-	-	HYPH
cord-023417-by18aczt	521	13	driving	drive	VBG
cord-023417-by18aczt	521	14	capacities	capacity	NNS
cord-023417-by18aczt	521	15	of	of	IN
cord-023417-by18aczt	521	16	the	the	DT
cord-023417-by18aczt	521	17	gut	gut	NN
cord-023417-by18aczt	521	18	DC	DC	NNP
cord-023417-by18aczt	521	19	to	to	TO
cord-023417-by18aczt	521	20	be	be	VB
cord-023417-by18aczt	521	21	modulated	modulate	VBN
cord-023417-by18aczt	521	22	according	accord	VBG
cord-023417-by18aczt	521	23	to	to	IN
cord-023417-by18aczt	521	24	composition	composition	NN
cord-023417-by18aczt	521	25	of	of	IN
cord-023417-by18aczt	521	26	gut	gut	NN
cord-023417-by18aczt	521	27	flora	flora	NNS
cord-023417-by18aczt	521	28	including	include	VBG
cord-023417-by18aczt	521	29	ingested	ingest	VBN
cord-023417-by18aczt	521	30	probiotics	probiotic	NNS
cord-023417-by18aczt	521	31	.	.	.
cord-023417-by18aczt	522	1	The	the	DT
cord-023417-by18aczt	522	2	intestinal	intestinal	JJ
cord-023417-by18aczt	522	3	micro	micro	NN
cord-023417-by18aczt	522	4	flora	flora	NNP
cord-023417-by18aczt	522	5	is	be	VBZ
cord-023417-by18aczt	522	6	indispensable	indispensable	JJ
cord-023417-by18aczt	522	7	in	in	IN
cord-023417-by18aczt	522	8	developing	develop	VBG
cord-023417-by18aczt	522	9	and	and	CC
cord-023417-by18aczt	522	10	maintaining	maintain	VBG
cord-023417-by18aczt	522	11	homeostasis	homeostasis	NN
cord-023417-by18aczt	522	12	of	of	IN
cord-023417-by18aczt	522	13	the	the	DT
cord-023417-by18aczt	522	14	gut	gut	NN
cord-023417-by18aczt	522	15	-	-	HYPH
cord-023417-by18aczt	522	16	associated	associate	VBN
cord-023417-by18aczt	522	17	immune	immune	JJ
cord-023417-by18aczt	522	18	system	system	NN
cord-023417-by18aczt	522	19	.	.	.
cord-023417-by18aczt	523	1	Evidence	evidence	NN
cord-023417-by18aczt	523	2	indicates	indicate	VBZ
cord-023417-by18aczt	523	3	that	that	IN
cord-023417-by18aczt	523	4	lactic	lactic	JJ
cord-023417-by18aczt	523	5	acid	acid	NN
cord-023417-by18aczt	523	6	bacteria	bacteria	NNS
cord-023417-by18aczt	523	7	(	(	-LRB-
cord-023417-by18aczt	523	8	LAB	lab	NN
cord-023417-by18aczt	523	9	)	)	-RRB-
cord-023417-by18aczt	523	10	,	,	,
cord-023417-by18aczt	523	11	e.g.	e.g.	IN
cord-023417-by18aczt	523	12	lactobacilli	lactobacilli	NN
cord-023417-by18aczt	523	13	and	and	CC
cord-023417-by18aczt	523	14	bifidobacteria	bifidobacteria	NNP
cord-023417-by18aczt	523	15	,	,	,
cord-023417-by18aczt	523	16	have	have	VBP
cord-023417-by18aczt	523	17	beneficial	beneficial	JJ
cord-023417-by18aczt	523	18	effects	effect	NNS
cord-023417-by18aczt	523	19	on	on	IN
cord-023417-by18aczt	523	20	the	the	DT
cord-023417-by18aczt	523	21	host	host	NN
cord-023417-by18aczt	523	22	.	.	.
cord-023417-by18aczt	524	1	Established	establish	VBN
cord-023417-by18aczt	524	2	health	health	NN
cord-023417-by18aczt	524	3	effects	effect	NNS
cord-023417-by18aczt	524	4	include	include	VBP
cord-023417-by18aczt	524	5	increased	increase	VBN
cord-023417-by18aczt	524	6	gut	gut	NN
cord-023417-by18aczt	524	7	maturation	maturation	NN
cord-023417-by18aczt	524	8	,	,	,
cord-023417-by18aczt	524	9	antagonisms	antagonism	NNS
cord-023417-by18aczt	524	10	towards	towards	IN
cord-023417-by18aczt	524	11	pathogens	pathogen	NNS
cord-023417-by18aczt	524	12	and	and	CC
cord-023417-by18aczt	524	13	immune	immune	JJ
cord-023417-by18aczt	524	14	modulation	modulation	NN
cord-023417-by18aczt	524	15	.	.	.
cord-023417-by18aczt	525	1	The	the	DT
cord-023417-by18aczt	525	2	objective	objective	NN
cord-023417-by18aczt	525	3	of	of	IN
cord-023417-by18aczt	525	4	this	this	DT
cord-023417-by18aczt	525	5	study	study	NN
cord-023417-by18aczt	525	6	is	be	VBZ
cord-023417-by18aczt	525	7	to	to	TO
cord-023417-by18aczt	525	8	evaluate	evaluate	VB
cord-023417-by18aczt	525	9	the	the	DT
cord-023417-by18aczt	525	10	immunomodulating	immunomodulate	VBG
cord-023417-by18aczt	525	11	properties	property	NNS
cord-023417-by18aczt	525	12	of	of	IN
cord-023417-by18aczt	525	13	a	a	DT
cord-023417-by18aczt	525	14	range	range	NN
cord-023417-by18aczt	525	15	of	of	IN
cord-023417-by18aczt	525	16	LAB	lab	NN
cord-023417-by18aczt	525	17	of	of	IN
cord-023417-by18aczt	525	18	human	human	JJ
cord-023417-by18aczt	525	19	origin	origin	NN
cord-023417-by18aczt	525	20	.	.	.
cord-023417-by18aczt	526	1	As	as	IN
cord-023417-by18aczt	526	2	dendritic	dendritic	JJ
cord-023417-by18aczt	526	3	cells	cell	NNS
cord-023417-by18aczt	526	4	(	(	-LRB-
cord-023417-by18aczt	526	5	DCs	DCs	NNP
cord-023417-by18aczt	526	6	)	)	-RRB-
cord-023417-by18aczt	526	7	play	play	VBP
cord-023417-by18aczt	526	8	a	a	DT
cord-023417-by18aczt	526	9	pivotal	pivotal	JJ
cord-023417-by18aczt	526	10	role	role	NN
cord-023417-by18aczt	526	11	in	in	IN
cord-023417-by18aczt	526	12	the	the	DT
cord-023417-by18aczt	526	13	balance	balance	NN
cord-023417-by18aczt	526	14	between	between	IN
cord-023417-by18aczt	526	15	tolerance	tolerance	NN
cord-023417-by18aczt	526	16	and	and	CC
cord-023417-by18aczt	526	17	immunity	immunity	NN
cord-023417-by18aczt	526	18	to	to	IN
cord-023417-by18aczt	526	19	commensal	commensal	JJ
cord-023417-by18aczt	526	20	microorganisms	microorganism	NNS
cord-023417-by18aczt	526	21	,	,	,
cord-023417-by18aczt	526	22	in	in	IN
cord-023417-by18aczt	526	23	vitro	vitro	FW
cord-023417-by18aczt	526	24	-	-	HYPH
cord-023417-by18aczt	526	25	generated	generate	VBN
cord-023417-by18aczt	526	26	immature	immature	JJ
cord-023417-by18aczt	526	27	DCs	dc	NNS
cord-023417-by18aczt	526	28	serve	serve	VBP
cord-023417-by18aczt	526	29	as	as	IN
cord-023417-by18aczt	526	30	a	a	DT
cord-023417-by18aczt	526	31	suitable	suitable	JJ
cord-023417-by18aczt	526	32	model	model	NN
cord-023417-by18aczt	526	33	for	for	IN
cord-023417-by18aczt	526	34	studying	study	VBG
cord-023417-by18aczt	526	35	the	the	DT
cord-023417-by18aczt	526	36	immunomodulating	immunomodulating	JJ
cord-023417-by18aczt	526	37	effects	effect	NNS
cord-023417-by18aczt	526	38	of	of	IN
cord-023417-by18aczt	526	39	lab	lab	NN
cord-023417-by18aczt	526	40	.	.	.
cord-023417-by18aczt	527	1	Human	human	JJ
cord-023417-by18aczt	527	2	immature	immature	JJ
cord-023417-by18aczt	527	3	DCs	dc	NNS
cord-023417-by18aczt	527	4	were	be	VBD
cord-023417-by18aczt	527	5	generated	generate	VBN
cord-023417-by18aczt	527	6	in	in	IN
cord-023417-by18aczt	527	7	vitro	vitro	FW
cord-023417-by18aczt	527	8	from	from	IN
cord-023417-by18aczt	527	9	monocytes	monocyte	NNS
cord-023417-by18aczt	527	10	and	and	CC
cord-023417-by18aczt	527	11	exposed	expose	VBN
cord-023417-by18aczt	527	12	to	to	IN
cord-023417-by18aczt	527	13	lethally	lethally	RB
cord-023417-by18aczt	527	14	UV	uv	NN
cord-023417-by18aczt	527	15	-	-	HYPH
cord-023417-by18aczt	527	16	irradiated	irradiate	VBN
cord-023417-by18aczt	527	17	LAB	lab	NN
cord-023417-by18aczt	527	18	.	.	.
cord-023417-by18aczt	528	1	The	the	DT
cord-023417-by18aczt	528	2	effect	effect	NN
cord-023417-by18aczt	528	3	of	of	IN
cord-023417-by18aczt	528	4	various	various	JJ
cord-023417-by18aczt	528	5	species	specie	NNS
cord-023417-by18aczt	528	6	of	of	IN
cord-023417-by18aczt	528	7	LAB	lab	NN
cord-023417-by18aczt	528	8	on	on	IN
cord-023417-by18aczt	528	9	DCs	dc	NNS
cord-023417-by18aczt	528	10	in	in	IN
cord-023417-by18aczt	528	11	direct	direct	JJ
cord-023417-by18aczt	528	12	contact	contact	NN
cord-023417-by18aczt	528	13	was	be	VBD
cord-023417-by18aczt	528	14	evaluated	evaluate	VBN
cord-023417-by18aczt	528	15	.	.	.
cord-023417-by18aczt	529	1	Furthermore	furthermore	RB
cord-023417-by18aczt	529	2	,	,	,
cord-023417-by18aczt	529	3	the	the	DT
cord-023417-by18aczt	529	4	maturation	maturation	NN
cord-023417-by18aczt	529	5	pattern	pattern	NN
cord-023417-by18aczt	529	6	of	of	IN
cord-023417-by18aczt	529	7	DCs	dc	NNS
cord-023417-by18aczt	529	8	separated	separate	VBD
cord-023417-by18aczt	529	9	from	from	IN
cord-023417-by18aczt	529	10	the	the	DT
cord-023417-by18aczt	529	11	bacteria	bacteria	NNS
cord-023417-by18aczt	529	12	by	by	IN
cord-023417-by18aczt	529	13	an	an	DT
cord-023417-by18aczt	529	14	epithelial	epithelial	JJ
cord-023417-by18aczt	529	15	cell	cell	NN
cord-023417-by18aczt	529	16	layer	layer	NN
cord-023417-by18aczt	529	17	(	(	-LRB-
cord-023417-by18aczt	529	18	CaCo-2	CaCo-2	NNP
cord-023417-by18aczt	529	19	cells	cell	NNS
cord-023417-by18aczt	529	20	)	)	-RRB-
cord-023417-by18aczt	529	21	,	,	,
cord-023417-by18aczt	529	22	which	which	WDT
cord-023417-by18aczt	529	23	should	should	MD
cord-023417-by18aczt	529	24	mimic	mimic	VB
cord-023417-by18aczt	529	25	the	the	DT
cord-023417-by18aczt	529	26	intestinal	intestinal	JJ
cord-023417-by18aczt	529	27	environment	environment	NN
cord-023417-by18aczt	529	28	,	,	,
cord-023417-by18aczt	529	29	was	be	VBD
cord-023417-by18aczt	529	30	studied	study	VBN
cord-023417-by18aczt	529	31	.	.	.
cord-023417-by18aczt	530	1	Cytokine	cytokine	NN
cord-023417-by18aczt	530	2	secretion	secretion	NN
cord-023417-by18aczt	530	3	(	(	-LRB-
cord-023417-by18aczt	530	4	IL-12	IL-12	NNP
cord-023417-by18aczt	530	5	,	,	,
cord-023417-by18aczt	530	6	IL-10	IL-10	NNP
cord-023417-by18aczt	530	7	and	and	CC
cord-023417-by18aczt	530	8	TNF	TNF	NNP
cord-023417-by18aczt	530	9	-	-	HYPH
cord-023417-by18aczt	530	10	a	a	LS
cord-023417-by18aczt	530	11	)	)	-RRB-
cord-023417-by18aczt	530	12	and	and	CC
cord-023417-by18aczt	530	13	upregulation	upregulation	NN
cord-023417-by18aczt	530	14	of	of	IN
cord-023417-by18aczt	530	15	maturation	maturation	NN
cord-023417-by18aczt	530	16	surface	surface	NN
cord-023417-by18aczt	530	17	markers	marker	NNS
cord-023417-by18aczt	530	18	on	on	IN
cord-023417-by18aczt	530	19	DCs	DCs	NNP
cord-023417-by18aczt	530	20	(	(	-LRB-
cord-023417-by18aczt	530	21	CD83	CD83	NNP
cord-023417-by18aczt	530	22	and	and	CC
cord-023417-by18aczt	530	23	CD86	CD86	NNP
cord-023417-by18aczt	530	24	)	)	-RRB-
cord-023417-by18aczt	530	25	was	be	VBD
cord-023417-by18aczt	530	26	measured	measure	VBN
cord-023417-by18aczt	530	27	.	.	.
cord-023417-by18aczt	531	1	Different	different	JJ
cord-023417-by18aczt	531	2	LAB	lab	NN
cord-023417-by18aczt	531	3	induced	induce	VBN
cord-023417-by18aczt	531	4	diverse	diverse	JJ
cord-023417-by18aczt	531	5	cytokine	cytokine	NN
cord-023417-by18aczt	531	6	responses	response	NNS
cord-023417-by18aczt	531	7	.	.	.
cord-023417-by18aczt	532	1	Some	some	DT
cord-023417-by18aczt	532	2	strains	strain	NNS
cord-023417-by18aczt	532	3	were	be	VBD
cord-023417-by18aczt	532	4	strong	strong	JJ
cord-023417-by18aczt	532	5	IL-12	IL-12	NNP
cord-023417-by18aczt	532	6	and	and	CC
cord-023417-by18aczt	532	7	TNF	TNF	NNP
cord-023417-by18aczt	532	8	-	-	,
cord-023417-by18aczt	532	9	a	a	DT
cord-023417-by18aczt	532	10	inducers	inducer	NNS
cord-023417-by18aczt	532	11	and	and	CC
cord-023417-by18aczt	532	12	others	other	NNS
cord-023417-by18aczt	532	13	weak	weak	JJ
cord-023417-by18aczt	532	14	.	.	.
cord-023417-by18aczt	533	1	All	all	DT
cord-023417-by18aczt	533	2	strains	strain	NNS
cord-023417-by18aczt	533	3	induced	induce	VBN
cord-023417-by18aczt	533	4	IL-10	IL-10	NNP
cord-023417-by18aczt	533	5	.	.	.
cord-023417-by18aczt	534	1	Different	different	JJ
cord-023417-by18aczt	534	2	LAB	lab	NN
cord-023417-by18aczt	534	3	also	also	RB
cord-023417-by18aczt	534	4	differentially	differentially	RB
cord-023417-by18aczt	534	5	modulated	modulate	VBN
cord-023417-by18aczt	534	6	expression	expression	NN
cord-023417-by18aczt	534	7	of	of	IN
cord-023417-by18aczt	534	8	CD83	CD83	NNP
cord-023417-by18aczt	534	9	and	and	CC
cord-023417-by18aczt	534	10	CD86	CD86	NNP
cord-023417-by18aczt	534	11	on	on	IN
cord-023417-by18aczt	534	12	DCs	dc	NNS
cord-023417-by18aczt	534	13	.	.	.
cord-023417-by18aczt	535	1	Although	although	IN
cord-023417-by18aczt	535	2	some	some	DT
cord-023417-by18aczt	535	3	variation	variation	NN
cord-023417-by18aczt	535	4	in	in	IN
cord-023417-by18aczt	535	5	the	the	DT
cord-023417-by18aczt	535	6	response	response	NN
cord-023417-by18aczt	535	7	to	to	IN
cord-023417-by18aczt	535	8	LAB	LAB	NNP
cord-023417-by18aczt	535	9	of	of	IN
cord-023417-by18aczt	535	10	DCs	dc	NNS
cord-023417-by18aczt	535	11	generated	generate	VBN
cord-023417-by18aczt	535	12	from	from	IN
cord-023417-by18aczt	535	13	different	different	JJ
cord-023417-by18aczt	535	14	blood	blood	NN
cord-023417-by18aczt	535	15	donors	donor	NNS
cord-023417-by18aczt	535	16	was	be	VBD
cord-023417-by18aczt	535	17	observed	observe	VBN
cord-023417-by18aczt	535	18	,	,	,
cord-023417-by18aczt	535	19	general	general	JJ
cord-023417-by18aczt	535	20	differences	difference	NNS
cord-023417-by18aczt	535	21	in	in	IN
cord-023417-by18aczt	535	22	the	the	DT
cord-023417-by18aczt	535	23	effect	effect	NN
cord-023417-by18aczt	535	24	of	of	IN
cord-023417-by18aczt	535	25	the	the	DT
cord-023417-by18aczt	535	26	various	various	JJ
cord-023417-by18aczt	535	27	LAB	lab	NN
cord-023417-by18aczt	535	28	was	be	VBD
cord-023417-by18aczt	535	29	revealed	reveal	VBN
cord-023417-by18aczt	535	30	.	.	.
cord-023417-by18aczt	536	1	Experiments	experiment	NNS
cord-023417-by18aczt	536	2	with	with	IN
cord-023417-by18aczt	536	3	the	the	DT
cord-023417-by18aczt	536	4	DC	DC	NNP
cord-023417-by18aczt	536	5	CaCo-2	CaCo-2	NNP
cord-023417-by18aczt	536	6	coculture	coculture	NN
cord-023417-by18aczt	536	7	system	system	NN
cord-023417-by18aczt	536	8	are	be	VBP
cord-023417-by18aczt	536	9	ongoing	ongoing	JJ
cord-023417-by18aczt	536	10	.	.	.
cord-023417-by18aczt	537	1	Different	different	JJ
cord-023417-by18aczt	537	2	species	specie	NNS
cord-023417-by18aczt	537	3	of	of	IN
cord-023417-by18aczt	537	4	LAB	lab	NN
cord-023417-by18aczt	537	5	differentially	differentially	RB
cord-023417-by18aczt	537	6	affect	affect	VBP
cord-023417-by18aczt	537	7	DC	DC	NNP
cord-023417-by18aczt	537	8	maturation	maturation	NN
cord-023417-by18aczt	537	9	;	;	:
cord-023417-by18aczt	537	10	this	this	DT
cord-023417-by18aczt	537	11	suggets	sugget	VBZ
cord-023417-by18aczt	537	12	that	that	IN
cord-023417-by18aczt	537	13	the	the	DT
cord-023417-by18aczt	537	14	gut	gut	NN
cord-023417-by18aczt	537	15	flora	flora	NN
cord-023417-by18aczt	537	16	plays	play	VBZ
cord-023417-by18aczt	537	17	a	a	DT
cord-023417-by18aczt	537	18	pivotal	pivotal	JJ
cord-023417-by18aczt	537	19	role	role	NN
cord-023417-by18aczt	537	20	in	in	IN
cord-023417-by18aczt	537	21	polarization	polarization	NN
cord-023417-by18aczt	537	22	of	of	IN
cord-023417-by18aczt	537	23	the	the	DT
cord-023417-by18aczt	537	24	immune	immune	JJ
cord-023417-by18aczt	537	25	response	response	NN
cord-023417-by18aczt	537	26	.	.	.
cord-023417-by18aczt	538	1	Natural	natural	JJ
cord-023417-by18aczt	538	2	killer	killer	NN
cord-023417-by18aczt	538	3	(	(	-LRB-
cord-023417-by18aczt	538	4	NK	NK	NNP
cord-023417-by18aczt	538	5	)	)	-RRB-
cord-023417-by18aczt	538	6	cells	cell	NNS
cord-023417-by18aczt	538	7	are	be	VBP
cord-023417-by18aczt	538	8	cells	cell	NNS
cord-023417-by18aczt	538	9	of	of	IN
cord-023417-by18aczt	538	10	the	the	DT
cord-023417-by18aczt	538	11	nonspecific	nonspecific	JJ
cord-023417-by18aczt	538	12	immune	immune	JJ
cord-023417-by18aczt	538	13	system	system	NN
cord-023417-by18aczt	538	14	lysing	lyse	VBG
cord-023417-by18aczt	538	15	altered	alter	VBD
cord-023417-by18aczt	538	16	self	self	NN
cord-023417-by18aczt	538	17	-	-	HYPH
cord-023417-by18aczt	538	18	cells	cell	NNS
cord-023417-by18aczt	538	19	.	.	.
cord-023417-by18aczt	539	1	A	a	DT
cord-023417-by18aczt	539	2	noncytolytic	noncytolytic	JJ
cord-023417-by18aczt	539	3	subset	subset	VBN
cord-023417-by18aczt	539	4	of	of	IN
cord-023417-by18aczt	539	5	NK	NK	NNP
cord-023417-by18aczt	539	6	cells	cell	NNS
cord-023417-by18aczt	539	7	may	may	MD
cord-023417-by18aczt	539	8	serve	serve	VB
cord-023417-by18aczt	539	9	a	a	DT
cord-023417-by18aczt	539	10	regulatory	regulatory	JJ
cord-023417-by18aczt	539	11	role	role	NN
cord-023417-by18aczt	539	12	by	by	IN
cord-023417-by18aczt	539	13	secreting	secrete	VBG
cord-023417-by18aczt	539	14	cytokines	cytokine	NNS
cord-023417-by18aczt	539	15	.	.	.
cord-023417-by18aczt	540	1	Bacteria	Bacteria	NNS
cord-023417-by18aczt	540	2	translocating	translocate	VBG
cord-023417-by18aczt	540	3	across	across	IN
cord-023417-by18aczt	540	4	the	the	DT
cord-023417-by18aczt	540	5	gastrointestinal	gastrointestinal	JJ
cord-023417-by18aczt	540	6	mucosa	mucosa	NN
cord-023417-by18aczt	540	7	are	be	VBP
cord-023417-by18aczt	540	8	presumed	presume	VBN
cord-023417-by18aczt	540	9	to	to	TO
cord-023417-by18aczt	540	10	gain	gain	VB
cord-023417-by18aczt	540	11	access	access	NN
cord-023417-by18aczt	540	12	to	to	IN
cord-023417-by18aczt	540	13	NK	NK	NNP
cord-023417-by18aczt	540	14	cells	cell	NNS
cord-023417-by18aczt	540	15	,	,	,
cord-023417-by18aczt	540	16	as	as	IN
cord-023417-by18aczt	540	17	consumption	consumption	NN
cord-023417-by18aczt	540	18	of	of	IN
cord-023417-by18aczt	540	19	certain	certain	JJ
cord-023417-by18aczt	540	20	lactic	lactic	JJ
cord-023417-by18aczt	540	21	acid	acid	NN
cord-023417-by18aczt	540	22	bacteria	bacteria	NNS
cord-023417-by18aczt	540	23	has	have	VBZ
cord-023417-by18aczt	540	24	been	be	VBN
cord-023417-by18aczt	540	25	shown	show	VBN
cord-023417-by18aczt	540	26	to	to	TO
cord-023417-by18aczt	540	27	increase	increase	VB
cord-023417-by18aczt	540	28	in	in	IN
cord-023417-by18aczt	540	29	vivo	vivo	NN
cord-023417-by18aczt	540	30	NK	nk	NN
cord-023417-by18aczt	540	31	cytotoxicity	cytotoxicity	NN
cord-023417-by18aczt	540	32	.	.	.
cord-023417-by18aczt	541	1	Here	here	RB
cord-023417-by18aczt	541	2	,	,	,
cord-023417-by18aczt	541	3	we	-PRON-	PRP
cord-023417-by18aczt	541	4	investigated	investigate	VBD
cord-023417-by18aczt	541	5	how	how	WRB
cord-023417-by18aczt	541	6	human	human	JJ
cord-023417-by18aczt	541	7	gut	gut	NN
cord-023417-by18aczt	541	8	flora	flora	NNS
cord-023417-by18aczt	541	9	-	-	HYPH
cord-023417-by18aczt	541	10	derived	derive	VBN
cord-023417-by18aczt	541	11	lactobacilli	lactobacilli	NN
cord-023417-by18aczt	541	12	affect	affect	VBP
cord-023417-by18aczt	541	13	NK	NK	NNP
cord-023417-by18aczt	541	14	cells	cell	NNS
cord-023417-by18aczt	541	15	in	in	IN
cord-023417-by18aczt	541	16	vitro	vitro	FW
cord-023417-by18aczt	541	17	,	,	,
cord-023417-by18aczt	541	18	by	by	IN
cord-023417-by18aczt	541	19	measuring	measure	VBG
cord-023417-by18aczt	541	20	proliferation	proliferation	NN
cord-023417-by18aczt	541	21	and	and	CC
cord-023417-by18aczt	541	22	IFN	IFN	NNP
cord-023417-by18aczt	541	23	-	-	HYPH
cord-023417-by18aczt	541	24	g	g	NN
cord-023417-by18aczt	541	25	production	production	NN
cord-023417-by18aczt	541	26	of	of	IN
cord-023417-by18aczt	541	27	human	human	JJ
cord-023417-by18aczt	541	28	NK	NK	NNP
cord-023417-by18aczt	541	29	cells	cell	NNS
cord-023417-by18aczt	541	30	upon	upon	IN
cord-023417-by18aczt	541	31	bacterial	bacterial	JJ
cord-023417-by18aczt	541	32	stimulation	stimulation	NN
cord-023417-by18aczt	541	33	.	.	.
cord-023417-by18aczt	542	1	CD3	CD3	NNP
cord-023417-by18aczt	542	2	-CD56	-CD56	NNP
cord-023417-by18aczt	542	3	þ	þ	NNP
cord-023417-by18aczt	542	4	NK	NK	NNP
cord-023417-by18aczt	542	5	cells	cell	NNS
cord-023417-by18aczt	542	6	were	be	VBD
cord-023417-by18aczt	542	7	isolated	isolate	VBN
cord-023417-by18aczt	542	8	from	from	IN
cord-023417-by18aczt	542	9	buffy	buffy	NNP
cord-023417-by18aczt	542	10	coats	coat	NNS
cord-023417-by18aczt	542	11	by	by	IN
cord-023417-by18aczt	542	12	negative	negative	JJ
cord-023417-by18aczt	542	13	isolation	isolation	NN
cord-023417-by18aczt	542	14	using	use	VBG
cord-023417-by18aczt	542	15	non	non	JJ
cord-023417-by18aczt	542	16	-	-	JJ
cord-023417-by18aczt	542	17	NK	nk	JJ
cord-023417-by18aczt	542	18	lineage	lineage	NN
cord-023417-by18aczt	542	19	-	-	HYPH
cord-023417-by18aczt	542	20	specific	specific	JJ
cord-023417-by18aczt	542	21	antibodies	antibody	NNS
cord-023417-by18aczt	542	22	and	and	CC
cord-023417-by18aczt	542	23	magnetic	magnetic	JJ
cord-023417-by18aczt	542	24	beads	bead	NNS
cord-023417-by18aczt	542	25	.	.	.
cord-023417-by18aczt	543	1	NK	NK	NNP
cord-023417-by18aczt	543	2	cells	cell	NNS
cord-023417-by18aczt	543	3	were	be	VBD
cord-023417-by18aczt	543	4	incubated	incubate	VBN
cord-023417-by18aczt	543	5	with	with	IN
cord-023417-by18aczt	543	6	10mg	10mg	NNP
cord-023417-by18aczt	543	7	/	/	SYM
cord-023417-by18aczt	543	8	ml	ml	NN
cord-023417-by18aczt	543	9	UV	uv	NN
cord-023417-by18aczt	543	10	-	-	HYPH
cord-023417-by18aczt	543	11	inactivated	inactivate	VBN
cord-023417-by18aczt	543	12	bacteria	bacteria	NNS
cord-023417-by18aczt	543	13	or	or	CC
cord-023417-by18aczt	543	14	10mg	10mg	NN
cord-023417-by18aczt	543	15	/	/	SYM
cord-023417-by18aczt	543	16	ml	ml	NN
cord-023417-by18aczt	543	17	phytohemagglutinin	phytohemagglutinin	NNP
cord-023417-by18aczt	543	18	(	(	-LRB-
cord-023417-by18aczt	543	19	PHA	PHA	NNP
cord-023417-by18aczt	543	20	)	)	-RRB-
cord-023417-by18aczt	543	21	for	for	IN
cord-023417-by18aczt	543	22	4	4	CD
cord-023417-by18aczt	543	23	days	day	NNS
cord-023417-by18aczt	543	24	.	.	.
cord-023417-by18aczt	544	1	Proliferation	proliferation	NN
cord-023417-by18aczt	544	2	was	be	VBD
cord-023417-by18aczt	544	3	assessed	assess	VBN
cord-023417-by18aczt	544	4	by	by	IN
cord-023417-by18aczt	544	5	incorporation	incorporation	NN
cord-023417-by18aczt	544	6	of	of	IN
cord-023417-by18aczt	544	7	radioactive	radioactive	JJ
cord-023417-by18aczt	544	8	thymidine	thymidine	NN
cord-023417-by18aczt	544	9	into	into	IN
cord-023417-by18aczt	544	10	NK	nk	NN
cord-023417-by18aczt	544	11	-	-	HYPH
cord-023417-by18aczt	544	12	cell	cell	NN
cord-023417-by18aczt	544	13	DNA	dna	NN
cord-023417-by18aczt	544	14	.	.	.
cord-023417-by18aczt	545	1	The	the	DT
cord-023417-by18aczt	545	2	IFN	IFN	NNP
cord-023417-by18aczt	545	3	-	-	HYPH
cord-023417-by18aczt	545	4	g	g	NN
cord-023417-by18aczt	545	5	concentration	concentration	NN
cord-023417-by18aczt	545	6	was	be	VBD
cord-023417-by18aczt	545	7	measured	measure	VBN
cord-023417-by18aczt	545	8	by	by	IN
cord-023417-by18aczt	545	9	ELISA	ELISA	NNP
cord-023417-by18aczt	545	10	.	.	.
cord-023417-by18aczt	546	1	Incubation	Incubation	NNP
cord-023417-by18aczt	546	2	of	of	IN
cord-023417-by18aczt	546	3	NK	NK	NNP
cord-023417-by18aczt	546	4	cells	cell	NNS
cord-023417-by18aczt	546	5	with	with	IN
cord-023417-by18aczt	546	6	a	a	DT
cord-023417-by18aczt	546	7	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	546	8	acidophilus	acidophilus	NN
cord-023417-by18aczt	546	9	strain	strain	NN
cord-023417-by18aczt	546	10	increased	increase	VBD
cord-023417-by18aczt	546	11	the	the	DT
cord-023417-by18aczt	546	12	proliferation	proliferation	NN
cord-023417-by18aczt	546	13	of	of	IN
cord-023417-by18aczt	546	14	the	the	DT
cord-023417-by18aczt	546	15	NK	NK	NNP
cord-023417-by18aczt	546	16	cells	cell	NNS
cord-023417-by18aczt	546	17	and	and	CC
cord-023417-by18aczt	546	18	induced	induce	VBD
cord-023417-by18aczt	546	19	IFN	IFN	NNP
cord-023417-by18aczt	546	20	-	-	HYPH
cord-023417-by18aczt	546	21	g	g	NN
cord-023417-by18aczt	546	22	production	production	NN
cord-023417-by18aczt	546	23	,	,	,
cord-023417-by18aczt	546	24	both	both	DT
cord-023417-by18aczt	546	25	to	to	IN
cord-023417-by18aczt	546	26	levels	level	NNS
cord-023417-by18aczt	546	27	comparable	comparable	JJ
cord-023417-by18aczt	546	28	to	to	IN
cord-023417-by18aczt	546	29	PHA	PHA	NNP
cord-023417-by18aczt	546	30	stimulation	stimulation	NN
cord-023417-by18aczt	546	31	.	.	.
cord-023417-by18aczt	547	1	The	the	DT
cord-023417-by18aczt	547	2	proliferative	proliferative	JJ
cord-023417-by18aczt	547	3	response	response	NN
cord-023417-by18aczt	547	4	was	be	VBD
cord-023417-by18aczt	547	5	further	further	RB
cord-023417-by18aczt	547	6	enhanced	enhance	VBN
cord-023417-by18aczt	547	7	with	with	IN
cord-023417-by18aczt	547	8	autologous	autologous	JJ
cord-023417-by18aczt	547	9	monocytes	monocyte	NNS
cord-023417-by18aczt	547	10	present	present	JJ
cord-023417-by18aczt	547	11	,	,	,
cord-023417-by18aczt	547	12	probably	probably	RB
cord-023417-by18aczt	547	13	because	because	IN
cord-023417-by18aczt	547	14	cytokines	cytokine	NNS
cord-023417-by18aczt	547	15	,	,	,
cord-023417-by18aczt	547	16	secreted	secrete	VBN
cord-023417-by18aczt	547	17	by	by	IN
cord-023417-by18aczt	547	18	monocytes	monocyte	NNS
cord-023417-by18aczt	547	19	having	have	VBG
cord-023417-by18aczt	547	20	engulfed	engulf	VBN
cord-023417-by18aczt	547	21	bacteria	bacteria	NNS
cord-023417-by18aczt	547	22	,	,	,
cord-023417-by18aczt	547	23	stimulated	stimulate	VBD
cord-023417-by18aczt	547	24	the	the	DT
cord-023417-by18aczt	547	25	NK	NK	NNP
cord-023417-by18aczt	547	26	cells	cell	NNS
cord-023417-by18aczt	547	27	.	.	.
cord-023417-by18aczt	548	1	In	in	IN
cord-023417-by18aczt	548	2	contrast	contrast	NN
cord-023417-by18aczt	548	3	,	,	,
cord-023417-by18aczt	548	4	a	a	DT
cord-023417-by18aczt	548	5	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	548	6	paracasei	paracasei	NN
cord-023417-by18aczt	548	7	strain	strain	NN
cord-023417-by18aczt	548	8	caused	cause	VBD
cord-023417-by18aczt	548	9	the	the	DT
cord-023417-by18aczt	548	10	NK	NK	NNP
cord-023417-by18aczt	548	11	cells	cell	NNS
cord-023417-by18aczt	548	12	to	to	TO
cord-023417-by18aczt	548	13	proliferate	proliferate	VB
cord-023417-by18aczt	548	14	only	only	RB
cord-023417-by18aczt	548	15	in	in	IN
cord-023417-by18aczt	548	16	the	the	DT
cord-023417-by18aczt	548	17	presence	presence	NN
cord-023417-by18aczt	548	18	of	of	IN
cord-023417-by18aczt	548	19	monocytes	monocyte	NNS
cord-023417-by18aczt	548	20	.	.	.
cord-023417-by18aczt	549	1	These	these	DT
cord-023417-by18aczt	549	2	results	result	NNS
cord-023417-by18aczt	549	3	demonstrate	demonstrate	VBP
cord-023417-by18aczt	549	4	that	that	IN
cord-023417-by18aczt	549	5	various	various	JJ
cord-023417-by18aczt	549	6	strains	strain	NNS
cord-023417-by18aczt	549	7	of	of	IN
cord-023417-by18aczt	549	8	lactobacilli	lactobacillus	NNS
cord-023417-by18aczt	549	9	have	have	VBP
cord-023417-by18aczt	549	10	the	the	DT
cord-023417-by18aczt	549	11	capacity	capacity	NN
cord-023417-by18aczt	549	12	to	to	TO
cord-023417-by18aczt	549	13	activate	activate	VB
cord-023417-by18aczt	549	14	NK	NK	NNP
cord-023417-by18aczt	549	15	cells	cell	NNS
cord-023417-by18aczt	549	16	in	in	IN
cord-023417-by18aczt	549	17	vitro	vitro	FW
cord-023417-by18aczt	549	18	,	,	,
cord-023417-by18aczt	549	19	in	in	IN
cord-023417-by18aczt	549	20	a	a	DT
cord-023417-by18aczt	549	21	monocyte	monocyte	NN
cord-023417-by18aczt	549	22	-	-	HYPH
cord-023417-by18aczt	549	23	dependent	dependent	JJ
cord-023417-by18aczt	549	24	or	or	CC
cord-023417-by18aczt	549	25	-independent	-independent	JJ
cord-023417-by18aczt	549	26	way	way	NN
cord-023417-by18aczt	549	27	.	.	.
cord-023417-by18aczt	550	1	Hence	hence	RB
cord-023417-by18aczt	550	2	,	,	,
cord-023417-by18aczt	550	3	the	the	DT
cord-023417-by18aczt	550	4	encounter	encounter	NN
cord-023417-by18aczt	550	5	of	of	IN
cord-023417-by18aczt	550	6	NK	NK	NNP
cord-023417-by18aczt	550	7	cells	cell	NNS
cord-023417-by18aczt	550	8	with	with	IN
cord-023417-by18aczt	550	9	lactic	lactic	JJ
cord-023417-by18aczt	550	10	acid	acid	NN
cord-023417-by18aczt	550	11	bacteria	bacteria	NNS
cord-023417-by18aczt	550	12	will	will	MD
cord-023417-by18aczt	550	13	affect	affect	VB
cord-023417-by18aczt	550	14	NK	NK	NNP
cord-023417-by18aczt	550	15	-	-	HYPH
cord-023417-by18aczt	550	16	cell	cell	NN
cord-023417-by18aczt	550	17	activation	activation	NN
cord-023417-by18aczt	550	18	.	.	.
cord-023417-by18aczt	551	1	Such	such	JJ
cord-023417-by18aczt	551	2	activation	activation	NN
cord-023417-by18aczt	551	3	of	of	IN
cord-023417-by18aczt	551	4	NK	NK	NNP
cord-023417-by18aczt	551	5	cells	cell	NNS
cord-023417-by18aczt	551	6	may	may	MD
cord-023417-by18aczt	551	7	potentially	potentially	RB
cord-023417-by18aczt	551	8	skew	skew	VB
cord-023417-by18aczt	551	9	an	an	DT
cord-023417-by18aczt	551	10	on	on	RB
cord-023417-by18aczt	551	11	-	-	HYPH
cord-023417-by18aczt	551	12	going	going	NN
cord-023417-by18aczt	551	13	or	or	CC
cord-023417-by18aczt	551	14	subsequent	subsequent	JJ
cord-023417-by18aczt	551	15	immune	immune	JJ
cord-023417-by18aczt	551	16	response	response	NN
cord-023417-by18aczt	551	17	towards	towards	IN
cord-023417-by18aczt	551	18	a	a	DT
cord-023417-by18aczt	551	19	Th1	th1	CD
cord-023417-by18aczt	551	20	response	response	NN
cord-023417-by18aczt	551	21	.	.	.
cord-023417-by18aczt	552	1	Lactobacilli	Lactobacilli	NNP
cord-023417-by18aczt	552	2	are	be	VBP
cord-023417-by18aczt	552	3	nonpathogenic	nonpathogenic	NNP
cord-023417-by18aczt	552	4	gram	gram	NN
cord-023417-by18aczt	552	5	-	-	HYPH
cord-023417-by18aczt	552	6	positive	positive	JJ
cord-023417-by18aczt	552	7	inhabitants	inhabitant	NNS
cord-023417-by18aczt	552	8	of	of	IN
cord-023417-by18aczt	552	9	the	the	DT
cord-023417-by18aczt	552	10	normal	normal	JJ
cord-023417-by18aczt	552	11	human	human	JJ
cord-023417-by18aczt	552	12	intestine	intestine	NN
cord-023417-by18aczt	552	13	known	know	VBN
cord-023417-by18aczt	552	14	for	for	IN
cord-023417-by18aczt	552	15	their	-PRON-	PRP$
cord-023417-by18aczt	552	16	healthpromoting	healthpromote	VBG
cord-023417-by18aczt	552	17	effects	effect	NNS
cord-023417-by18aczt	552	18	.	.	.
cord-023417-by18aczt	553	1	In	in	IN
cord-023417-by18aczt	553	2	our	-PRON-	PRP$
cord-023417-by18aczt	553	3	earlier	early	JJR
cord-023417-by18aczt	553	4	work	work	NN
cord-023417-by18aczt	553	5	,	,	,
cord-023417-by18aczt	553	6	it	-PRON-	PRP
cord-023417-by18aczt	553	7	is	be	VBZ
cord-023417-by18aczt	553	8	shown	show	VBN
cord-023417-by18aczt	553	9	that	that	IN
cord-023417-by18aczt	553	10	human	human	JJ
cord-023417-by18aczt	553	11	monoclonal	monoclonal	JJ
cord-023417-by18aczt	553	12	antibody	antibody	NN
cord-023417-by18aczt	553	13	isolated	isolate	VBN
cord-023417-by18aczt	553	14	from	from	IN
cord-023417-by18aczt	553	15	sera	sera	NNP
cord-023417-by18aczt	553	16	of	of	IN
cord-023417-by18aczt	553	17	a	a	DT
cord-023417-by18aczt	553	18	patient	patient	NN
cord-023417-by18aczt	553	19	with	with	IN
cord-023417-by18aczt	553	20	Waldenstrom	Waldenstrom	NNP
cord-023417-by18aczt	553	21	macroglobulinaemia	macroglobulinaemia	NN
cord-023417-by18aczt	553	22	possess	possess	VBP
cord-023417-by18aczt	553	23	innate	innate	JJ
cord-023417-by18aczt	553	24	antibody	antibody	NN
cord-023417-by18aczt	553	25	characteristics	characteristic	NNS
cord-023417-by18aczt	553	26	and	and	CC
cord-023417-by18aczt	553	27	binds	bind	VBZ
cord-023417-by18aczt	553	28	to	to	IN
cord-023417-by18aczt	553	29	lactic	lactic	JJ
cord-023417-by18aczt	553	30	acid	acid	NN
cord-023417-by18aczt	553	31	bacteria	bacteria	NNS
cord-023417-by18aczt	553	32	.	.	.
cord-023417-by18aczt	554	1	According	accord	VBG
cord-023417-by18aczt	554	2	to	to	IN
cord-023417-by18aczt	554	3	the	the	DT
cord-023417-by18aczt	554	4	immune	immune	JJ
cord-023417-by18aczt	554	5	network	network	NN
cord-023417-by18aczt	554	6	model	model	NN
cord-023417-by18aczt	554	7	,	,	,
cord-023417-by18aczt	554	8	immunization	immunization	NN
cord-023417-by18aczt	554	9	with	with	IN
cord-023417-by18aczt	554	10	this	this	DT
cord-023417-by18aczt	554	11	bacteria	bacteria	NNS
cord-023417-by18aczt	554	12	could	could	MD
cord-023417-by18aczt	554	13	induce	induce	VB
cord-023417-by18aczt	554	14	the	the	DT
cord-023417-by18aczt	554	15	perturbations	perturbation	NNS
cord-023417-by18aczt	554	16	in	in	IN
cord-023417-by18aczt	554	17	immune	immune	JJ
cord-023417-by18aczt	554	18	system	system	NN
cord-023417-by18aczt	554	19	that	that	WDT
cord-023417-by18aczt	554	20	might	may	MD
cord-023417-by18aczt	554	21	result	result	VB
cord-023417-by18aczt	554	22	in	in	IN
cord-023417-by18aczt	554	23	production	production	NN
cord-023417-by18aczt	554	24	of	of	IN
cord-023417-by18aczt	554	25	anti	anti	JJ
cord-023417-by18aczt	554	26	-	-	JJ
cord-023417-by18aczt	554	27	Lactobacillus	lactobacillus	JJ
cord-023417-by18aczt	554	28	antibodies	antibody	NNS
cord-023417-by18aczt	554	29	,	,	,
cord-023417-by18aczt	554	30	human	human	JJ
cord-023417-by18aczt	554	31	monoclonal	monoclonal	JJ
cord-023417-by18aczt	554	32	antibody	antibody	NN
cord-023417-by18aczt	554	33	like	like	IN
cord-023417-by18aczt	554	34	(	(	-LRB-
cord-023417-by18aczt	554	35	Ab1	ab1	NN
cord-023417-by18aczt	554	36	)	)	-RRB-
cord-023417-by18aczt	554	37	and	and	CC
cord-023417-by18aczt	554	38	anti	anti	JJ
cord-023417-by18aczt	554	39	-	-	JJ
cord-023417-by18aczt	554	40	idiotypic	idiotypic	JJ
cord-023417-by18aczt	554	41	antibody	antibody	NN
cord-023417-by18aczt	554	42	(	(	-LRB-
cord-023417-by18aczt	554	43	Ab2	ab2	NN
cord-023417-by18aczt	554	44	)	)	-RRB-
cord-023417-by18aczt	554	45	.	.	.
cord-023417-by18aczt	555	1	In	in	IN
cord-023417-by18aczt	555	2	this	this	DT
cord-023417-by18aczt	555	3	study	study	NN
cord-023417-by18aczt	555	4	,	,	,
cord-023417-by18aczt	555	5	BALB	BALB	NNP
cord-023417-by18aczt	555	6	/	/	SYM
cord-023417-by18aczt	555	7	c	c	NN
cord-023417-by18aczt	555	8	mice	mouse	NNS
cord-023417-by18aczt	555	9	were	be	VBD
cord-023417-by18aczt	555	10	immunized	immunize	VBN
cord-023417-by18aczt	555	11	with	with	IN
cord-023417-by18aczt	555	12	two	two	CD
cord-023417-by18aczt	555	13	doses	dose	NNS
cord-023417-by18aczt	555	14	of	of	IN
cord-023417-by18aczt	555	15	bacteria	bacteria	NNS
cord-023417-by18aczt	555	16	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	555	17	acidophilus	acidophilus	NN
cord-023417-by18aczt	555	18	in	in	IN
cord-023417-by18aczt	555	19	complete	complete	JJ
cord-023417-by18aczt	555	20	and	and	CC
cord-023417-by18aczt	555	21	incomplete	incomplete	JJ
cord-023417-by18aczt	555	22	Freund	Freund	NNP
cord-023417-by18aczt	555	23	's	's	POS
cord-023417-by18aczt	555	24	adjuvant	adjuvant	NN
cord-023417-by18aczt	555	25	and	and	CC
cord-023417-by18aczt	555	26	phosphate	phosphate	NN
cord-023417-by18aczt	555	27	-	-	HYPH
cord-023417-by18aczt	555	28	buffered	buffer	VBN
cord-023417-by18aczt	555	29	saline	saline	NN
cord-023417-by18aczt	555	30	(	(	-LRB-
cord-023417-by18aczt	555	31	PBS	PBS	NNP
cord-023417-by18aczt	555	32	)	)	-RRB-
cord-023417-by18aczt	555	33	,	,	,
cord-023417-by18aczt	555	34	respectively	respectively	RB
cord-023417-by18aczt	555	35	.	.	.
cord-023417-by18aczt	556	1	Seven	seven	CD
cord-023417-by18aczt	556	2	days	day	NNS
cord-023417-by18aczt	556	3	after	after	IN
cord-023417-by18aczt	556	4	the	the	DT
cord-023417-by18aczt	556	5	last	last	JJ
cord-023417-by18aczt	556	6	immunization	immunization	NN
cord-023417-by18aczt	556	7	,	,	,
cord-023417-by18aczt	556	8	sera	sera	NNP
cord-023417-by18aczt	556	9	from	from	IN
cord-023417-by18aczt	556	10	immunized	immunize	VBN
cord-023417-by18aczt	556	11	mice	mouse	NNS
cord-023417-by18aczt	556	12	were	be	VBD
cord-023417-by18aczt	556	13	collected	collect	VBN
cord-023417-by18aczt	556	14	and	and	CC
cord-023417-by18aczt	556	15	the	the	DT
cord-023417-by18aczt	556	16	presence	presence	NN
cord-023417-by18aczt	556	17	of	of	IN
cord-023417-by18aczt	556	18	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	556	19	-	-	HYPH
cord-023417-by18aczt	556	20	specific	specific	JJ
cord-023417-by18aczt	556	21	Ab1	ab1	NN
cord-023417-by18aczt	556	22	and	and	CC
cord-023417-by18aczt	556	23	Ab2	ab2	NN
cord-023417-by18aczt	556	24	were	be	VBD
cord-023417-by18aczt	556	25	determined	determine	VBN
cord-023417-by18aczt	556	26	by	by	IN
cord-023417-by18aczt	556	27	ELISAs	elisa	NNS
cord-023417-by18aczt	556	28	.	.	.
cord-023417-by18aczt	557	1	In	in	IN
cord-023417-by18aczt	557	2	the	the	DT
cord-023417-by18aczt	557	3	sera	sera	NNP
cord-023417-by18aczt	557	4	of	of	IN
cord-023417-by18aczt	557	5	immunized	immunize	VBN
cord-023417-by18aczt	557	6	mice	mouse	NNS
cord-023417-by18aczt	557	7	,	,	,
cord-023417-by18aczt	557	8	antibodies	antibody	NNS
cord-023417-by18aczt	557	9	specific	specific	JJ
cord-023417-by18aczt	557	10	to	to	IN
cord-023417-by18aczt	557	11	bacteria	bacteria	NNS
cord-023417-by18aczt	557	12	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	557	13	acidophilus	acidophilus	NN
cord-023417-by18aczt	557	14	were	be	VBD
cord-023417-by18aczt	557	15	shown	show	VBN
cord-023417-by18aczt	557	16	.	.	.
cord-023417-by18aczt	558	1	The	the	DT
cord-023417-by18aczt	558	2	concentration	concentration	NN
cord-023417-by18aczt	558	3	of	of	IN
cord-023417-by18aczt	558	4	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	558	5	-	-	HYPH
cord-023417-by18aczt	558	6	specific	specific	JJ
cord-023417-by18aczt	558	7	antibodies	antibody	NNS
cord-023417-by18aczt	558	8	was	be	VBD
cord-023417-by18aczt	558	9	higher	high	JJR
cord-023417-by18aczt	558	10	in	in	IN
cord-023417-by18aczt	558	11	the	the	DT
cord-023417-by18aczt	558	12	sera	sera	NNP
cord-023417-by18aczt	558	13	of	of	IN
cord-023417-by18aczt	558	14	hyperimmunized	hyperimmunize	VBN
cord-023417-by18aczt	558	15	mice	mouse	NNS
cord-023417-by18aczt	558	16	(	(	-LRB-
cord-023417-by18aczt	558	17	mice	mouse	NNS
cord-023417-by18aczt	558	18	immunized	immunize	VBN
cord-023417-by18aczt	558	19	with	with	IN
cord-023417-by18aczt	558	20	1	1	CD
cord-023417-by18aczt	558	21	mg	mg	NNP
cord-023417-by18aczt	558	22	of	of	IN
cord-023417-by18aczt	558	23	IgM	IgM	NNP
cord-023417-by18aczt	558	24	DJ	DJ	NNP
cord-023417-by18aczt	558	25	)	)	-RRB-
cord-023417-by18aczt	558	26	than	than	IN
cord-023417-by18aczt	558	27	in	in	IN
cord-023417-by18aczt	558	28	sera	sera	NNP
cord-023417-by18aczt	558	29	of	of	IN
cord-023417-by18aczt	558	30	mice	mouse	NNS
cord-023417-by18aczt	558	31	immunized	immunize	VBN
cord-023417-by18aczt	558	32	with	with	IN
cord-023417-by18aczt	558	33	100	100	CD
cord-023417-by18aczt	558	34	times	time	NNS
cord-023417-by18aczt	558	35	lower	low	JJR
cord-023417-by18aczt	558	36	doses	dose	NNS
cord-023417-by18aczt	558	37	of	of	IN
cord-023417-by18aczt	558	38	immunogen	immunogen	NN
cord-023417-by18aczt	558	39	(	(	-LRB-
cord-023417-by18aczt	558	40	0.01	0.01	CD
cord-023417-by18aczt	558	41	mg	mg	NN
cord-023417-by18aczt	558	42	per	per	IN
cord-023417-by18aczt	558	43	doses	dose	NNS
cord-023417-by18aczt	558	44	)	)	-RRB-
cord-023417-by18aczt	558	45	.	.	.
cord-023417-by18aczt	559	1	Moreover	moreover	RB
cord-023417-by18aczt	559	2	,	,	,
cord-023417-by18aczt	559	3	Ab1	ab1	NN
cord-023417-by18aczt	559	4	and	and	CC
cord-023417-by18aczt	559	5	Ab2	ab2	NN
cord-023417-by18aczt	559	6	antibodies	antibody	NNS
cord-023417-by18aczt	559	7	were	be	VBD
cord-023417-by18aczt	559	8	detected	detect	VBN
cord-023417-by18aczt	559	9	in	in	IN
cord-023417-by18aczt	559	10	the	the	DT
cord-023417-by18aczt	559	11	sera	sera	NNP
cord-023417-by18aczt	559	12	of	of	IN
cord-023417-by18aczt	559	13	Lactobacillus	Lactobacillus	NNP
cord-023417-by18aczt	559	14	-	-	HYPH
cord-023417-by18aczt	559	15	hyperimmunized	hyperimmunize	VBN
cord-023417-by18aczt	559	16	mice	mouse	NNS
cord-023417-by18aczt	559	17	.	.	.
cord-023417-by18aczt	560	1	In	in	IN
cord-023417-by18aczt	560	2	this	this	DT
cord-023417-by18aczt	560	3	study	study	NN
cord-023417-by18aczt	560	4	,	,	,
cord-023417-by18aczt	560	5	we	-PRON-	PRP
cord-023417-by18aczt	560	6	have	have	VBP
cord-023417-by18aczt	560	7	shown	show	VBN
cord-023417-by18aczt	560	8	the	the	DT
cord-023417-by18aczt	560	9	idiotypic	idiotypic	NNP
cord-023417-by18aczt	560	10	network	network	NN
cord-023417-by18aczt	560	11	interactions	interaction	NNS
cord-023417-by18aczt	560	12	in	in	IN
cord-023417-by18aczt	560	13	mice	mouse	NNS
cord-023417-by18aczt	560	14	immunized	immunize	VBN
cord-023417-by18aczt	560	15	with	with	IN
cord-023417-by18aczt	560	16	bacteria	bacteria	NNS
cord-023417-by18aczt	560	17	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	560	18	acidophilus	acidophilus	NN
cord-023417-by18aczt	560	19	.	.	.
cord-023417-by18aczt	561	1	The	the	DT
cord-023417-by18aczt	561	2	normal	normal	JJ
cord-023417-by18aczt	561	3	gastrointestinal	gastrointestinal	JJ
cord-023417-by18aczt	561	4	flora	flora	NNS
cord-023417-by18aczt	561	5	is	be	VBZ
cord-023417-by18aczt	561	6	crucial	crucial	JJ
cord-023417-by18aczt	561	7	for	for	IN
cord-023417-by18aczt	561	8	the	the	DT
cord-023417-by18aczt	561	9	maturation	maturation	NN
cord-023417-by18aczt	561	10	of	of	IN
cord-023417-by18aczt	561	11	the	the	DT
cord-023417-by18aczt	561	12	acquired	acquire	VBN
cord-023417-by18aczt	561	13	immunity	immunity	NN
cord-023417-by18aczt	561	14	via	via	IN
cord-023417-by18aczt	561	15	effects	effect	NNS
cord-023417-by18aczt	561	16	on	on	IN
cord-023417-by18aczt	561	17	antigenpresenting	antigenpresente	VBG
cord-023417-by18aczt	561	18	cells	cell	NNS
cord-023417-by18aczt	561	19	(	(	-LRB-
cord-023417-by18aczt	561	20	APCs	apc	NNS
cord-023417-by18aczt	561	21	)	)	-RRB-
cord-023417-by18aczt	561	22	.	.	.
cord-023417-by18aczt	562	1	Here	here	RB
cord-023417-by18aczt	562	2	,	,	,
cord-023417-by18aczt	562	3	we	-PRON-	PRP
cord-023417-by18aczt	562	4	have	have	VBP
cord-023417-by18aczt	562	5	investigated	investigate	VBN
cord-023417-by18aczt	562	6	how	how	WRB
cord-023417-by18aczt	562	7	two	two	CD
cord-023417-by18aczt	562	8	types	type	NNS
cord-023417-by18aczt	562	9	of	of	IN
cord-023417-by18aczt	562	10	APCs	apc	NNS
cord-023417-by18aczt	562	11	,	,	,
cord-023417-by18aczt	562	12	monocytes	monocyte	NNS
cord-023417-by18aczt	562	13	and	and	CC
cord-023417-by18aczt	562	14	dendritic	dendritic	JJ
cord-023417-by18aczt	562	15	cells	cell	NNS
cord-023417-by18aczt	562	16	(	(	-LRB-
cord-023417-by18aczt	562	17	DCs	DCs	NNP
cord-023417-by18aczt	562	18	)	)	-RRB-
cord-023417-by18aczt	562	19	,	,	,
cord-023417-by18aczt	562	20	react	react	VBP
cord-023417-by18aczt	562	21	to	to	IN
cord-023417-by18aczt	562	22	different	different	JJ
cord-023417-by18aczt	562	23	bacterial	bacterial	JJ
cord-023417-by18aczt	562	24	strains	strain	NNS
cord-023417-by18aczt	562	25	typical	typical	JJ
cord-023417-by18aczt	562	26	of	of	IN
cord-023417-by18aczt	562	27	the	the	DT
cord-023417-by18aczt	562	28	commensal	commensal	JJ
cord-023417-by18aczt	562	29	intestinal	intestinal	JJ
cord-023417-by18aczt	562	30	flora	flora	NNS
cord-023417-by18aczt	562	31	.	.	.
cord-023417-by18aczt	563	1	Purified	purify	VBN
cord-023417-by18aczt	563	2	monocytes	monocyte	NNS
cord-023417-by18aczt	563	3	and	and	CC
cord-023417-by18aczt	563	4	monocyte	monocyte	NN
cord-023417-by18aczt	563	5	-	-	HYPH
cord-023417-by18aczt	563	6	derived	derive	VBN
cord-023417-by18aczt	563	7	DCs	dc	NNS
cord-023417-by18aczt	563	8	were	be	VBD
cord-023417-by18aczt	563	9	stimulated	stimulate	VBN
cord-023417-by18aczt	563	10	with	with	IN
cord-023417-by18aczt	563	11	UV	uv	NN
cord-023417-by18aczt	563	12	-	-	HYPH
cord-023417-by18aczt	563	13	inactivated	inactivate	VBN
cord-023417-by18aczt	563	14	gram	gram	NN
cord-023417-by18aczt	563	15	-	-	HYPH
cord-023417-by18aczt	563	16	positive	positive	JJ
cord-023417-by18aczt	563	17	(	(	-LRB-
cord-023417-by18aczt	563	18	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	563	19	plantarum	plantarum	NNS
cord-023417-by18aczt	563	20	and	and	CC
cord-023417-by18aczt	563	21	Bifidobacterium	Bifidobacterium	NNP
cord-023417-by18aczt	563	22	adolescentis	adolescentis	NNP
cord-023417-by18aczt	563	23	)	)	-RRB-
cord-023417-by18aczt	563	24	and	and	CC
cord-023417-by18aczt	563	25	gram	gram	NN
cord-023417-by18aczt	563	26	-	-	HYPH
cord-023417-by18aczt	563	27	negative	negative	JJ
cord-023417-by18aczt	563	28	(	(	-LRB-
cord-023417-by18aczt	563	29	Escherichia	escherichia	NN
cord-023417-by18aczt	563	30	coli	coli	NNS
cord-023417-by18aczt	563	31	and	and	CC
cord-023417-by18aczt	563	32	Veillonella	Veillonella	NNP
cord-023417-by18aczt	563	33	parvula	parvula	NN
cord-023417-by18aczt	563	34	)	)	-RRB-
cord-023417-by18aczt	563	35	bacterial	bacterial	JJ
cord-023417-by18aczt	563	36	strains	strain	NNS
cord-023417-by18aczt	563	37	.	.	.
cord-023417-by18aczt	564	1	Monocytes	monocyte	NNS
cord-023417-by18aczt	564	2	produced	produce	VBD
cord-023417-by18aczt	564	3	higher	high	JJR
cord-023417-by18aczt	564	4	levels	level	NNS
cord-023417-by18aczt	564	5	of	of	IN
cord-023417-by18aczt	564	6	IL-12p70	IL-12p70	NNP
cord-023417-by18aczt	564	7	and	and	CC
cord-023417-by18aczt	564	8	TNF	TNF	NNP
cord-023417-by18aczt	564	9	,	,	,
cord-023417-by18aczt	564	10	as	as	IN
cord-023417-by18aczt	564	11	detected	detect	VBN
cord-023417-by18aczt	564	12	by	by	IN
cord-023417-by18aczt	564	13	ELISA	ELISA	NNP
cord-023417-by18aczt	564	14	,	,	,
cord-023417-by18aczt	564	15	in	in	IN
cord-023417-by18aczt	564	16	response	response	NN
cord-023417-by18aczt	564	17	to	to	IN
cord-023417-by18aczt	564	18	L.	L.	NNP
cord-023417-by18aczt	564	19	plantarum	plantarum	NNS
cord-023417-by18aczt	564	20	than	than	IN
cord-023417-by18aczt	564	21	to	to	IN
cord-023417-by18aczt	564	22	E.	E.	NNP
cord-023417-by18aczt	564	23	coli	coli	NNS
cord-023417-by18aczt	564	24	and	and	CC
cord-023417-by18aczt	564	25	V.	V.	NNP
cord-023417-by18aczt	564	26	parvula	parvula	NNP
cord-023417-by18aczt	564	27	.	.	.
cord-023417-by18aczt	565	1	In	in	IN
cord-023417-by18aczt	565	2	contrast	contrast	NN
cord-023417-by18aczt	565	3	,	,	,
cord-023417-by18aczt	565	4	DCs	DCs	NNP
cord-023417-by18aczt	565	5	secreted	secrete	VBD
cord-023417-by18aczt	565	6	high	high	JJ
cord-023417-by18aczt	565	7	amounts	amount	NNS
cord-023417-by18aczt	565	8	of	of	IN
cord-023417-by18aczt	565	9	IL-12p70	IL-12p70	NNP
cord-023417-by18aczt	565	10	,	,	,
cord-023417-by18aczt	565	11	TNF	TNF	NNP
cord-023417-by18aczt	565	12	,	,	,
cord-023417-by18aczt	565	13	IL-6	IL-6	NNP
cord-023417-by18aczt	565	14	and	and	CC
cord-023417-by18aczt	565	15	IL-10	IL-10	NNP
cord-023417-by18aczt	565	16	in	in	IN
cord-023417-by18aczt	565	17	response	response	NN
cord-023417-by18aczt	565	18	to	to	IN
cord-023417-by18aczt	565	19	E.	E.	NNP
cord-023417-by18aczt	565	20	coli	coli	NNS
cord-023417-by18aczt	565	21	and	and	CC
cord-023417-by18aczt	565	22	V.	V.	NNP
cord-023417-by18aczt	565	23	parvula	parvula	NN
cord-023417-by18aczt	565	24	but	but	CC
cord-023417-by18aczt	565	25	were	be	VBD
cord-023417-by18aczt	565	26	practically	practically	RB
cord-023417-by18aczt	565	27	unresponsive	unresponsive	JJ
cord-023417-by18aczt	565	28	to	to	IN
cord-023417-by18aczt	565	29	L.	L.	NNP
cord-023417-by18aczt	565	30	plantarum	plantarum	NNS
cord-023417-by18aczt	565	31	and	and	CC
cord-023417-by18aczt	565	32	B.	B.	NNP
cord-023417-by18aczt	565	33	adolescentis	adolescentis	NNP
cord-023417-by18aczt	565	34	.	.	.
cord-023417-by18aczt	566	1	The	the	DT
cord-023417-by18aczt	566	2	lack	lack	NN
cord-023417-by18aczt	566	3	of	of	IN
cord-023417-by18aczt	566	4	response	response	NN
cord-023417-by18aczt	566	5	to	to	IN
cord-023417-by18aczt	566	6	the	the	DT
cord-023417-by18aczt	566	7	gram	gram	NN
cord-023417-by18aczt	566	8	-	-	HYPH
cord-023417-by18aczt	566	9	positive	positive	JJ
cord-023417-by18aczt	566	10	strains	strain	NNS
cord-023417-by18aczt	566	11	correlated	correlate	VBN
cord-023417-by18aczt	566	12	with	with	IN
cord-023417-by18aczt	566	13	a	a	DT
cord-023417-by18aczt	566	14	lower	low	JJR
cord-023417-by18aczt	566	15	surface	surface	NN
cord-023417-by18aczt	566	16	expression	expression	NN
cord-023417-by18aczt	566	17	of	of	IN
cord-023417-by18aczt	566	18	Toll	Toll	NNP
cord-023417-by18aczt	566	19	-	-	HYPH
cord-023417-by18aczt	566	20	like	like	JJ
cord-023417-by18aczt	566	21	reseptor	reseptor	NNP
cord-023417-by18aczt	566	22	2	2	CD
cord-023417-by18aczt	566	23	(	(	-LRB-
cord-023417-by18aczt	566	24	TLR2	TLR2	NNP
cord-023417-by18aczt	566	25	)	)	-RRB-
cord-023417-by18aczt	566	26	on	on	IN
cord-023417-by18aczt	566	27	DCs	dc	NNS
cord-023417-by18aczt	566	28	compared	compare	VBN
cord-023417-by18aczt	566	29	to	to	IN
cord-023417-by18aczt	566	30	monocytes	monocyte	NNS
cord-023417-by18aczt	566	31	.	.	.
cord-023417-by18aczt	567	1	The	the	DT
cord-023417-by18aczt	567	2	surface	surface	NN
cord-023417-by18aczt	567	3	expression	expression	NN
cord-023417-by18aczt	567	4	of	of	IN
cord-023417-by18aczt	567	5	TLR4	TLR4	NNP
cord-023417-by18aczt	567	6	on	on	IN
cord-023417-by18aczt	567	7	DCs	dc	NNS
cord-023417-by18aczt	567	8	was	be	VBD
cord-023417-by18aczt	567	9	undetectable	undetectable	JJ
cord-023417-by18aczt	567	10	when	when	WRB
cord-023417-by18aczt	567	11	analysed	analyse	VBN
cord-023417-by18aczt	567	12	by	by	IN
cord-023417-by18aczt	567	13	flow	flow	NN
cord-023417-by18aczt	567	14	cytometry	cytometry	NN
cord-023417-by18aczt	567	15	,	,	,
cord-023417-by18aczt	567	16	but	but	CC
cord-023417-by18aczt	567	17	blocking	block	VBG
cord-023417-by18aczt	567	18	this	this	DT
cord-023417-by18aczt	567	19	receptor	receptor	NN
cord-023417-by18aczt	567	20	decreased	decrease	VBD
cord-023417-by18aczt	567	21	the	the	DT
cord-023417-by18aczt	567	22	TNF	TNF	NNP
cord-023417-by18aczt	567	23	production	production	NN
cord-023417-by18aczt	567	24	in	in	IN
cord-023417-by18aczt	567	25	response	response	NN
cord-023417-by18aczt	567	26	to	to	IN
cord-023417-by18aczt	567	27	V.	V.	NNP
cord-023417-by18aczt	567	28	parvula	parvula	NNP
cord-023417-by18aczt	567	29	,	,	,
cord-023417-by18aczt	567	30	indicating	indicate	VBG
cord-023417-by18aczt	567	31	that	that	IN
cord-023417-by18aczt	567	32	low	low	JJ
cord-023417-by18aczt	567	33	TLR4	tlr4	CD
cord-023417-by18aczt	567	34	expression	expression	NN
cord-023417-by18aczt	567	35	on	on	IN
cord-023417-by18aczt	567	36	DCs	DCs	NNP
cord-023417-by18aczt	567	37	is	be	VBZ
cord-023417-by18aczt	567	38	sufficient	sufficient	JJ
cord-023417-by18aczt	567	39	to	to	TO
cord-023417-by18aczt	567	40	mount	mount	VB
cord-023417-by18aczt	567	41	an	an	DT
cord-023417-by18aczt	567	42	inflammatory	inflammatory	JJ
cord-023417-by18aczt	567	43	response	response	NN
cord-023417-by18aczt	567	44	to	to	IN
cord-023417-by18aczt	567	45	gram	gram	JJ
cord-023417-by18aczt	567	46	-	-	HYPH
cord-023417-by18aczt	567	47	negative	negative	JJ
cord-023417-by18aczt	567	48	bacteria	bacteria	NNS
cord-023417-by18aczt	567	49	.	.	.
cord-023417-by18aczt	568	1	IFN	IFN	NNP
cord-023417-by18aczt	568	2	-	-	HYPH
cord-023417-by18aczt	568	3	g	g	NNP
cord-023417-by18aczt	568	4	increased	increase	VBD
cord-023417-by18aczt	568	5	the	the	DT
cord-023417-by18aczt	568	6	expression	expression	NN
cord-023417-by18aczt	568	7	of	of	IN
cord-023417-by18aczt	568	8	TLR4	TLR4	NNP
cord-023417-by18aczt	568	9	on	on	IN
cord-023417-by18aczt	568	10	DCs	dc	NNS
cord-023417-by18aczt	568	11	and	and	CC
cord-023417-by18aczt	568	12	also	also	RB
cord-023417-by18aczt	568	13	potentiated	potentiate	VBD
cord-023417-by18aczt	568	14	the	the	DT
cord-023417-by18aczt	568	15	cytokine	cytokine	NN
cord-023417-by18aczt	568	16	response	response	NN
cord-023417-by18aczt	568	17	to	to	IN
cord-023417-by18aczt	568	18	gram	gram	JJ
cord-023417-by18aczt	568	19	-	-	HYPH
cord-023417-by18aczt	568	20	negative	negative	JJ
cord-023417-by18aczt	568	21	bacteria	bacteria	NNS
cord-023417-by18aczt	568	22	.	.	.
cord-023417-by18aczt	569	1	Our	-PRON-	PRP$
cord-023417-by18aczt	569	2	results	result	NNS
cord-023417-by18aczt	569	3	indicate	indicate	VBP
cord-023417-by18aczt	569	4	that	that	IN
cord-023417-by18aczt	569	5	,	,	,
cord-023417-by18aczt	569	6	when	when	WRB
cord-023417-by18aczt	569	7	monocytes	monocyte	NNS
cord-023417-by18aczt	569	8	differentiate	differentiate	VBP
cord-023417-by18aczt	569	9	into	into	IN
cord-023417-by18aczt	569	10	DCs	dc	NNS
cord-023417-by18aczt	569	11	,	,	,
cord-023417-by18aczt	569	12	their	-PRON-	PRP$
cord-023417-by18aczt	569	13	ability	ability	NN
cord-023417-by18aczt	569	14	to	to	TO
cord-023417-by18aczt	569	15	respond	respond	VB
cord-023417-by18aczt	569	16	to	to	IN
cord-023417-by18aczt	569	17	different	different	JJ
cord-023417-by18aczt	569	18	commensal	commensal	JJ
cord-023417-by18aczt	569	19	bacteria	bacteria	NNS
cord-023417-by18aczt	569	20	dramatically	dramatically	RB
cord-023417-by18aczt	569	21	changes	change	NNS
cord-023417-by18aczt	569	22	,	,	,
cord-023417-by18aczt	569	23	thereby	thereby	RB
cord-023417-by18aczt	569	24	becoming	become	VBG
cord-023417-by18aczt	569	25	unresponsive	unresponsive	JJ
cord-023417-by18aczt	569	26	to	to	IN
cord-023417-by18aczt	569	27	probiotic	probiotic	JJ
cord-023417-by18aczt	569	28	gram	gram	NN
cord-023417-by18aczt	569	29	-	-	HYPH
cord-023417-by18aczt	569	30	positive	positive	JJ
cord-023417-by18aczt	569	31	bacteria	bacteria	NNS
cord-023417-by18aczt	569	32	.	.	.
cord-023417-by18aczt	570	1	These	these	DT
cord-023417-by18aczt	570	2	results	result	NNS
cord-023417-by18aczt	570	3	may	may	MD
cord-023417-by18aczt	570	4	have	have	VB
cord-023417-by18aczt	570	5	important	important	JJ
cord-023417-by18aczt	570	6	implications	implication	NNS
cord-023417-by18aczt	570	7	for	for	IN
cord-023417-by18aczt	570	8	the	the	DT
cord-023417-by18aczt	570	9	capacity	capacity	NN
cord-023417-by18aczt	570	10	of	of	IN
cord-023417-by18aczt	570	11	different	different	JJ
cord-023417-by18aczt	570	12	groups	group	NNS
cord-023417-by18aczt	570	13	of	of	IN
cord-023417-by18aczt	570	14	commensal	commensal	JJ
cord-023417-by18aczt	570	15	bacteria	bacteria	NNS
cord-023417-by18aczt	570	16	to	to	TO
cord-023417-by18aczt	570	17	regulate	regulate	VB
cord-023417-by18aczt	570	18	mucosal	mucosal	JJ
cord-023417-by18aczt	570	19	and	and	CC
cord-023417-by18aczt	570	20	systemic	systemic	JJ
cord-023417-by18aczt	570	21	immunity	immunity	NN
cord-023417-by18aczt	570	22	.	.	.
cord-023417-by18aczt	571	1	Probiotic	probiotic	JJ
cord-023417-by18aczt	571	2	bacteria	bacteria	NNS
cord-023417-by18aczt	571	3	,	,	,
cord-023417-by18aczt	571	4	e.g.	e.g.	RB
cord-023417-by18aczt	571	5	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	571	6	spp	spp	NNS
cord-023417-by18aczt	571	7	.	.	.
cord-023417-by18aczt	571	8	,	,	,
cord-023417-by18aczt	571	9	may	may	MD
cord-023417-by18aczt	571	10	improve	improve	VB
cord-023417-by18aczt	571	11	diseases	disease	NNS
cord-023417-by18aczt	571	12	such	such	JJ
cord-023417-by18aczt	571	13	as	as	IN
cord-023417-by18aczt	571	14	chronic	chronic	JJ
cord-023417-by18aczt	571	15	inflammatory	inflammatory	JJ
cord-023417-by18aczt	571	16	bowel	bowel	NN
cord-023417-by18aczt	571	17	disease	disease	NN
cord-023417-by18aczt	571	18	.	.	.
cord-023417-by18aczt	572	1	We	-PRON-	PRP
cord-023417-by18aczt	572	2	examined	examine	VBD
cord-023417-by18aczt	572	3	cytokine	cytokine	JJ
cord-023417-by18aczt	572	4	production	production	NN
cord-023417-by18aczt	572	5	and	and	CC
cord-023417-by18aczt	572	6	phenotypic	phenotypic	JJ
cord-023417-by18aczt	572	7	change	change	NN
cord-023417-by18aczt	572	8	after	after	IN
cord-023417-by18aczt	572	9	in	in	IN
cord-023417-by18aczt	572	10	vitro	vitro	FW
cord-023417-by18aczt	572	11	stimulation	stimulation	NN
cord-023417-by18aczt	572	12	of	of	IN
cord-023417-by18aczt	572	13	T	t	NN
cord-023417-by18aczt	572	14	cells	cell	NNS
cord-023417-by18aczt	572	15	from	from	IN
cord-023417-by18aczt	572	16	healthy	healthy	JJ
cord-023417-by18aczt	572	17	volunteers	volunteer	NNS
cord-023417-by18aczt	572	18	using	use	VBG
cord-023417-by18aczt	572	19	different	different	JJ
cord-023417-by18aczt	572	20	probiotic	probiotic	JJ
cord-023417-by18aczt	572	21	strains	strain	NNS
cord-023417-by18aczt	572	22	.	.	.
cord-023417-by18aczt	573	1	Methods	method	NNS
cord-023417-by18aczt	573	2	:	:	:
cord-023417-by18aczt	573	3	T	t	NN
cord-023417-by18aczt	573	4	cells	cell	NNS
cord-023417-by18aczt	573	5	were	be	VBD
cord-023417-by18aczt	573	6	cultured	culture	VBN
cord-023417-by18aczt	573	7	from	from	IN
cord-023417-by18aczt	573	8	colonic	colonic	JJ
cord-023417-by18aczt	573	9	biopsies	biopsy	NNS
cord-023417-by18aczt	573	10	from	from	IN
cord-023417-by18aczt	573	11	eight	eight	CD
cord-023417-by18aczt	573	12	healthy	healthy	JJ
cord-023417-by18aczt	573	13	volunteers	volunteer	NNS
cord-023417-by18aczt	573	14	(	(	-LRB-
cord-023417-by18aczt	573	15	Agnholt	Agnholt	NNP
cord-023417-by18aczt	573	16	and	and	CC
cord-023417-by18aczt	573	17	Kaltoft	Kaltoft	NNP
cord-023417-by18aczt	573	18	,	,	,
cord-023417-by18aczt	573	19	Exp	Exp	NNP
cord-023417-by18aczt	573	20	Clin	Clin	NNP
cord-023417-by18aczt	573	21	Immunogenet	Immunogenet	NNP
cord-023417-by18aczt	573	22	2001	2001	CD
cord-023417-by18aczt	573	23	;	;	:
cord-023417-by18aczt	573	24	18:213	18:213	CD
cord-023417-by18aczt	573	25	-	-	SYM
cord-023417-by18aczt	573	26	25	25	CD
cord-023417-by18aczt	573	27	)	)	-RRB-
cord-023417-by18aczt	573	28	,	,	,
cord-023417-by18aczt	573	29	and	and	CC
cord-023417-by18aczt	573	30	dendritic	dendritic	JJ
cord-023417-by18aczt	573	31	cells	cell	NNS
cord-023417-by18aczt	573	32	were	be	VBD
cord-023417-by18aczt	573	33	matured	mature	VBN
cord-023417-by18aczt	573	34	from	from	IN
cord-023417-by18aczt	573	35	their	-PRON-	PRP$
cord-023417-by18aczt	573	36	peripheral	peripheral	JJ
cord-023417-by18aczt	573	37	blood	blood	NN
cord-023417-by18aczt	573	38	mononuclear	mononuclear	NN
cord-023417-by18aczt	573	39	cells	cell	NNS
cord-023417-by18aczt	573	40	.	.	.
cord-023417-by18aczt	574	1	T	t	NN
cord-023417-by18aczt	574	2	-	-	HYPH
cord-023417-by18aczt	574	3	cell	cell	NN
cord-023417-by18aczt	574	4	cultures	culture	NNS
cord-023417-by18aczt	574	5	were	be	VBD
cord-023417-by18aczt	574	6	stimulated	stimulate	VBN
cord-023417-by18aczt	574	7	with	with	IN
cord-023417-by18aczt	574	8	autologous	autologous	JJ
cord-023417-by18aczt	574	9	bacterial	bacterial	JJ
cord-023417-by18aczt	574	10	sonicate	sonicate	NN
cord-023417-by18aczt	574	11	or	or	CC
cord-023417-by18aczt	574	12	strains	strain	NNS
cord-023417-by18aczt	574	13	of	of	IN
cord-023417-by18aczt	574	14	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	574	15	spp	spp	NNS
cord-023417-by18aczt	574	16	.	.	.
cord-023417-by18aczt	575	1	,	,	,
cord-023417-by18aczt	575	2	with	with	IN
cord-023417-by18aczt	575	3	and	and	CC
cord-023417-by18aczt	575	4	without	without	IN
cord-023417-by18aczt	575	5	the	the	DT
cord-023417-by18aczt	575	6	addition	addition	NN
cord-023417-by18aczt	575	7	of	of	IN
cord-023417-by18aczt	575	8	dendritic	dendritic	JJ
cord-023417-by18aczt	575	9	cells	cell	NNS
cord-023417-by18aczt	575	10	.	.	.
cord-023417-by18aczt	576	1	Cytokine	cytokine	NN
cord-023417-by18aczt	576	2	levels	level	NNS
cord-023417-by18aczt	576	3	(	(	-LRB-
cord-023417-by18aczt	576	4	TNF	TNF	NNP
cord-023417-by18aczt	576	5	-	-	HYPH
cord-023417-by18aczt	576	6	a	a	NNP
cord-023417-by18aczt	576	7	,	,	,
cord-023417-by18aczt	576	8	IFN	IFN	NNP
cord-023417-by18aczt	576	9	-	-	HYPH
cord-023417-by18aczt	576	10	g	g	NNP
cord-023417-by18aczt	576	11	,	,	,
cord-023417-by18aczt	576	12	IL-10	IL-10	NNP
cord-023417-by18aczt	576	13	and	and	CC
cord-023417-by18aczt	576	14	GM	GM	NNP
cord-023417-by18aczt	576	15	-	-	HYPH
cord-023417-by18aczt	576	16	CSF	CSF	NNP
cord-023417-by18aczt	576	17	)	)	-RRB-
cord-023417-by18aczt	576	18	and	and	CC
cord-023417-by18aczt	576	19	phenotype	phenotype	NN
cord-023417-by18aczt	576	20	(	(	-LRB-
cord-023417-by18aczt	576	21	CD3	CD3	NNP
cord-023417-by18aczt	576	22	,	,	,
cord-023417-by18aczt	576	23	CD4	CD4	NNP
cord-023417-by18aczt	576	24	,	,	,
cord-023417-by18aczt	576	25	CD25	CD25	NNP
cord-023417-by18aczt	576	26	and	and	CC
cord-023417-by18aczt	576	27	CD69	CD69	NNP
cord-023417-by18aczt	576	28	)	)	-RRB-
cord-023417-by18aczt	576	29	were	be	VBD
cord-023417-by18aczt	576	30	measured	measure	VBN
cord-023417-by18aczt	576	31	on	on	IN
cord-023417-by18aczt	576	32	day	day	NN
cord-023417-by18aczt	576	33	4	4	CD
cord-023417-by18aczt	576	34	.	.	.
cord-023417-by18aczt	577	1	Results	result	NNS
cord-023417-by18aczt	577	2	:	:	:
cord-023417-by18aczt	578	1	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	578	2	spp	spp	NNS
cord-023417-by18aczt	578	3	.	.	.
cord-023417-by18aczt	579	1	induced	induce	VBN
cord-023417-by18aczt	579	2	higher	high	JJR
cord-023417-by18aczt	579	3	productions	production	NNS
cord-023417-by18aczt	579	4	of	of	IN
cord-023417-by18aczt	579	5	TNF	TNF	NNP
cord-023417-by18aczt	579	6	-	-	:
cord-023417-by18aczt	579	7	a	a	NNP
cord-023417-by18aczt	579	8	and	and	CC
cord-023417-by18aczt	579	9	IL-10	IL-10	NNP
cord-023417-by18aczt	579	10	than	than	IN
cord-023417-by18aczt	579	11	did	do	VBD
cord-023417-by18aczt	579	12	autologous	autologous	JJ
cord-023417-by18aczt	579	13	bacteria	bacteria	NNS
cord-023417-by18aczt	579	14	.	.	.
cord-023417-by18aczt	580	1	In	in	IN
cord-023417-by18aczt	580	2	presence	presence	NN
cord-023417-by18aczt	580	3	of	of	IN
cord-023417-by18aczt	580	4	dendritic	dendritic	JJ
cord-023417-by18aczt	580	5	cells	cell	NNS
cord-023417-by18aczt	580	6	,	,	,
cord-023417-by18aczt	580	7	the	the	DT
cord-023417-by18aczt	580	8	production	production	NN
cord-023417-by18aczt	580	9	of	of	IN
cord-023417-by18aczt	580	10	all	all	DT
cord-023417-by18aczt	580	11	cytokines	cytokine	NNS
cord-023417-by18aczt	580	12	increased	increase	VBD
cord-023417-by18aczt	580	13	.	.	.
cord-023417-by18aczt	581	1	However	however	RB
cord-023417-by18aczt	581	2	,	,	,
cord-023417-by18aczt	581	3	the	the	DT
cord-023417-by18aczt	581	4	increases	increase	NNS
cord-023417-by18aczt	581	5	of	of	IN
cord-023417-by18aczt	581	6	IFN	IFN	NNP
cord-023417-by18aczt	581	7	-	-	HYPH
cord-023417-by18aczt	581	8	g	g	NNP
cord-023417-by18aczt	581	9	and	and	CC
cord-023417-by18aczt	581	10	TNF	TNF	NNP
cord-023417-by18aczt	581	11	-	-	,
cord-023417-by18aczt	581	12	a	a	NNP
cord-023417-by18aczt	581	13	were	be	VBD
cord-023417-by18aczt	581	14	more	more	RBR
cord-023417-by18aczt	581	15	pronounced	pronounced	JJ
cord-023417-by18aczt	581	16	in	in	IN
cord-023417-by18aczt	581	17	wells	well	NNS
cord-023417-by18aczt	581	18	with	with	IN
cord-023417-by18aczt	581	19	autologous	autologous	JJ
cord-023417-by18aczt	581	20	bacteria	bacteria	NNS
cord-023417-by18aczt	581	21	than	than	IN
cord-023417-by18aczt	581	22	in	in	IN
cord-023417-by18aczt	581	23	wells	well	NNS
cord-023417-by18aczt	581	24	with	with	IN
cord-023417-by18aczt	581	25	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	581	26	spp	spp	NNS
cord-023417-by18aczt	581	27	.	.	.
cord-023417-by18aczt	582	1	The	the	DT
cord-023417-by18aczt	582	2	addition	addition	NN
cord-023417-by18aczt	582	3	of	of	IN
cord-023417-by18aczt	582	4	dendritic	dendritic	JJ
cord-023417-by18aczt	582	5	cells	cell	NNS
cord-023417-by18aczt	582	6	upregulated	upregulate	VBD
cord-023417-by18aczt	582	7	CD25	cd25	JJ
cord-023417-by18aczt	582	8	expression	expression	NN
cord-023417-by18aczt	582	9	without	without	IN
cord-023417-by18aczt	582	10	simultaneous	simultaneous	JJ
cord-023417-by18aczt	582	11	upregulation	upregulation	NN
cord-023417-by18aczt	582	12	of	of	IN
cord-023417-by18aczt	582	13	CD69	CD69	NNP
cord-023417-by18aczt	582	14	.	.	.
cord-023417-by18aczt	583	1	The	the	DT
cord-023417-by18aczt	583	2	upregulation	upregulation	NN
cord-023417-by18aczt	583	3	was	be	VBD
cord-023417-by18aczt	583	4	pronounced	pronounce	VBN
cord-023417-by18aczt	583	5	after	after	IN
cord-023417-by18aczt	583	6	stimulation	stimulation	NN
cord-023417-by18aczt	583	7	with	with	IN
cord-023417-by18aczt	583	8	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	583	9	rhamnosus	rhamnosus	NN
cord-023417-by18aczt	583	10	GG	GG	NNP
cord-023417-by18aczt	583	11	compared	compare	VBN
cord-023417-by18aczt	583	12	with	with	IN
cord-023417-by18aczt	583	13	autologous	autologous	JJ
cord-023417-by18aczt	583	14	bacteria	bacteria	NNS
cord-023417-by18aczt	583	15	and	and	CC
cord-023417-by18aczt	583	16	other	other	JJ
cord-023417-by18aczt	583	17	lactobacilli	lactobacillus	NNS
cord-023417-by18aczt	583	18	.	.	.
cord-023417-by18aczt	584	1	Discussion	discussion	NN
cord-023417-by18aczt	584	2	:	:	:
cord-023417-by18aczt	585	1	In	in	IN
cord-023417-by18aczt	585	2	presence	presence	NN
cord-023417-by18aczt	585	3	of	of	IN
cord-023417-by18aczt	585	4	dendritic	dendritic	JJ
cord-023417-by18aczt	585	5	cells	cell	NNS
cord-023417-by18aczt	585	6	,	,	,
cord-023417-by18aczt	585	7	autologous	autologous	JJ
cord-023417-by18aczt	585	8	bacteria	bacteria	NNS
cord-023417-by18aczt	585	9	induced	induce	VBD
cord-023417-by18aczt	585	10	inflammatory	inflammatory	JJ
cord-023417-by18aczt	585	11	cytokines	cytokine	NNS
cord-023417-by18aczt	585	12	,	,	,
cord-023417-by18aczt	585	13	while	while	IN
cord-023417-by18aczt	585	14	probiotics	probiotic	NNS
cord-023417-by18aczt	585	15	mainly	mainly	RB
cord-023417-by18aczt	585	16	induced	induce	VBN
cord-023417-by18aczt	585	17	regulatory	regulatory	JJ
cord-023417-by18aczt	585	18	cytokines	cytokine	NNS
cord-023417-by18aczt	585	19	.	.	.
cord-023417-by18aczt	586	1	Lactobacillus	lactobacillus	NN
cord-023417-by18aczt	586	2	rhamnosus	rhamnosus	NN
cord-023417-by18aczt	586	3	GG	GG	NNP
cord-023417-by18aczt	586	4	induced	induce	VBD
cord-023417-by18aczt	586	5	a	a	DT
cord-023417-by18aczt	586	6	regulatory	regulatory	JJ
cord-023417-by18aczt	586	7	phenotype	phenotype	NN
cord-023417-by18aczt	586	8	(	(	-LRB-
cord-023417-by18aczt	586	9	cd25	cd25	NN
cord-023417-by18aczt	586	10	þ	þ	NNP
cord-023417-by18aczt	586	11	)	)	-RRB-
cord-023417-by18aczt	586	12	,	,	,
cord-023417-by18aczt	586	13	in	in	IN
cord-023417-by18aczt	586	14	part	part	NN
cord-023417-by18aczt	586	15	mediated	mediate	VBN
cord-023417-by18aczt	586	16	by	by	IN
cord-023417-by18aczt	586	17	dendritic	dendritic	JJ
cord-023417-by18aczt	586	18	cells	cell	NNS
cord-023417-by18aczt	586	19	.	.	.
cord-023417-by18aczt	587	1	Future	future	JJ
cord-023417-by18aczt	587	2	studies	study	NNS
cord-023417-by18aczt	587	3	will	will	MD
cord-023417-by18aczt	587	4	address	address	VB
cord-023417-by18aczt	587	5	whether	whether	IN
cord-023417-by18aczt	587	6	this	this	DT
cord-023417-by18aczt	587	7	shift	shift	NN
cord-023417-by18aczt	587	8	to	to	IN
cord-023417-by18aczt	587	9	a	a	DT
cord-023417-by18aczt	587	10	CD25	CD25	NNP
cord-023417-by18aczt	587	11	þ	þ	NNP
cord-023417-by18aczt	587	12	phenotype	phenotype	NN
cord-023417-by18aczt	587	13	represents	represent	VBZ
cord-023417-by18aczt	587	14	a	a	DT
cord-023417-by18aczt	587	15	differentiation	differentiation	NN
cord-023417-by18aczt	587	16	into	into	IN
cord-023417-by18aczt	587	17	competent	competent	JJ
cord-023417-by18aczt	587	18	regulatory	regulatory	JJ
cord-023417-by18aczt	587	19	T	t	NN
cord-023417-by18aczt	587	20	cells	cell	NNS
cord-023417-by18aczt	587	21	.	.	.
cord-023417-by18aczt	588	1	In	in	IN
cord-023417-by18aczt	588	2	a	a	DT
cord-023417-by18aczt	588	3	clinical	clinical	JJ
cord-023417-by18aczt	588	4	context	context	NN
cord-023417-by18aczt	588	5	,	,	,
cord-023417-by18aczt	588	6	such	such	JJ
cord-023417-by18aczt	588	7	cells	cell	NNS
cord-023417-by18aczt	588	8	might	may	MD
cord-023417-by18aczt	588	9	be	be	VB
cord-023417-by18aczt	588	10	used	use	VBN
cord-023417-by18aczt	588	11	for	for	IN
cord-023417-by18aczt	588	12	treatment	treatment	NN
cord-023417-by18aczt	588	13	of	of	IN
cord-023417-by18aczt	588	14	inflammatory	inflammatory	JJ
cord-023417-by18aczt	588	15	diseases	disease	NNS
cord-023417-by18aczt	588	16	.	.	.
cord-023417-by18aczt	589	1	Protein	protein	NN
cord-023417-by18aczt	589	2	microarrays	microarray	NNS
cord-023417-by18aczt	589	3	will	will	MD
cord-023417-by18aczt	589	4	play	play	VB
cord-023417-by18aczt	589	5	a	a	DT
cord-023417-by18aczt	589	6	key	key	JJ
cord-023417-by18aczt	589	7	role	role	NN
cord-023417-by18aczt	589	8	in	in	IN
cord-023417-by18aczt	589	9	the	the	DT
cord-023417-by18aczt	589	10	postgenomic	postgenomic	NN
cord-023417-by18aczt	589	11	era	era	NN
cord-023417-by18aczt	589	12	and	and	CC
cord-023417-by18aczt	589	13	offer	offer	VB
cord-023417-by18aczt	589	14	a	a	DT
cord-023417-by18aczt	589	15	unique	unique	JJ
cord-023417-by18aczt	589	16	possibility	possibility	NN
cord-023417-by18aczt	589	17	to	to	TO
cord-023417-by18aczt	589	18	perform	perform	VB
cord-023417-by18aczt	589	19	highthroughput	highthroughput	NN
cord-023417-by18aczt	589	20	global	global	JJ
cord-023417-by18aczt	589	21	proteome	proteome	NN
cord-023417-by18aczt	589	22	analysis	analysis	NN
cord-023417-by18aczt	589	23	.	.	.
cord-023417-by18aczt	590	1	A	a	DT
cord-023417-by18aczt	590	2	chip	chip	NN
cord-023417-by18aczt	590	3	can	can	MD
cord-023417-by18aczt	590	4	be	be	VB
cord-023417-by18aczt	590	5	printed	print	VBN
cord-023417-by18aczt	590	6	with	with	IN
cord-023417-by18aczt	590	7	thousands	thousand	NNS
cord-023417-by18aczt	590	8	of	of	IN
cord-023417-by18aczt	590	9	protein	protein	NN
cord-023417-by18aczt	590	10	probes	probe	NNS
cord-023417-by18aczt	590	11	(	(	-LRB-
cord-023417-by18aczt	590	12	e.g.	e.g.	IN
cord-023417-by18aczt	590	13	antibodies	antibody	NNS
cord-023417-by18aczt	590	14	)	)	-RRB-
cord-023417-by18aczt	590	15	,	,	,
cord-023417-by18aczt	590	16	the	the	DT
cord-023417-by18aczt	590	17	biological	biological	JJ
cord-023417-by18aczt	590	18	sample	sample	NN
cord-023417-by18aczt	590	19	added	add	VBD
cord-023417-by18aczt	590	20	(	(	-LRB-
cord-023417-by18aczt	590	21	e.g.	e.g.	RB
cord-023417-by18aczt	590	22	a	a	DT
cord-023417-by18aczt	590	23	proteome	proteome	NN
cord-023417-by18aczt	590	24	)	)	-RRB-
cord-023417-by18aczt	590	25	and	and	CC
cord-023417-by18aczt	590	26	any	any	DT
cord-023417-by18aczt	590	27	binding	binding	NN
cord-023417-by18aczt	590	28	detected	detect	VBN
cord-023417-by18aczt	590	29	.	.	.
cord-023417-by18aczt	591	1	We	-PRON-	PRP
cord-023417-by18aczt	591	2	aim	aim	VBP
cord-023417-by18aczt	591	3	to	to	TO
cord-023417-by18aczt	591	4	develop	develop	VB
cord-023417-by18aczt	591	5	protein	protein	NN
cord-023417-by18aczt	591	6	microarrays	microarray	NNS
cord-023417-by18aczt	591	7	based	base	VBN
cord-023417-by18aczt	591	8	on	on	IN
cord-023417-by18aczt	591	9	human	human	JJ
cord-023417-by18aczt	591	10	recombinant	recombinant	JJ
cord-023417-by18aczt	591	11	scFv	scfv	JJ
cord-023417-by18aczt	591	12	antibody	antibody	NN
cord-023417-by18aczt	591	13	fragments	fragment	NNS
cord-023417-by18aczt	591	14	for	for	IN
cord-023417-by18aczt	591	15	global	global	JJ
cord-023417-by18aczt	591	16	proteome	proteome	NN
cord-023417-by18aczt	591	17	analysis	analysis	NN
cord-023417-by18aczt	591	18	.	.	.
cord-023417-by18aczt	592	1	The	the	DT
cord-023417-by18aczt	592	2	concept	concept	NN
cord-023417-by18aczt	592	3	of	of	IN
cord-023417-by18aczt	592	4	comparing	compare	VBG
cord-023417-by18aczt	592	5	proteomic	proteomic	JJ
cord-023417-by18aczt	592	6	maps	map	NNS
cord-023417-by18aczt	592	7	of	of	IN
cord-023417-by18aczt	592	8	healthy	healthy	JJ
cord-023417-by18aczt	592	9	versus	versus	IN
cord-023417-by18aczt	592	10	diseased	diseased	JJ
cord-023417-by18aczt	592	11	samples	sample	NNS
cord-023417-by18aczt	592	12	will	will	MD
cord-023417-by18aczt	592	13	allow	allow	VB
cord-023417-by18aczt	592	14	diseasespecific	diseasespecific	JJ
cord-023417-by18aczt	592	15	proteins	protein	NNS
cord-023417-by18aczt	592	16	to	to	TO
cord-023417-by18aczt	592	17	be	be	VB
cord-023417-by18aczt	592	18	detected	detect	VBN
cord-023417-by18aczt	592	19	.	.	.
cord-023417-by18aczt	593	1	In	in	IN
cord-023417-by18aczt	593	2	fact	fact	NN
cord-023417-by18aczt	593	3	,	,	,
cord-023417-by18aczt	593	4	antibody	antibody	NN
cord-023417-by18aczt	593	5	microarrays	microarray	NNS
cord-023417-by18aczt	593	6	will	will	MD
cord-023417-by18aczt	593	7	allow	allow	VB
cord-023417-by18aczt	593	8	us	-PRON-	PRP
cord-023417-by18aczt	593	9	to	to	TO
cord-023417-by18aczt	593	10	perform	perform	VB
cord-023417-by18aczt	593	11	comparative	comparative	JJ
cord-023417-by18aczt	593	12	proteome	proteome	NN
cord-023417-by18aczt	593	13	analysis	analysis	NN
cord-023417-by18aczt	593	14	on	on	IN
cord-023417-by18aczt	593	15	any	any	DT
cord-023417-by18aczt	593	16	sample	sample	NN
cord-023417-by18aczt	593	17	format	format	NN
cord-023417-by18aczt	593	18	in	in	IN
cord-023417-by18aczt	593	19	a	a	DT
cord-023417-by18aczt	593	20	species	species	NN
cord-023417-by18aczt	593	21	-	-	HYPH
cord-023417-by18aczt	593	22	independent	independent	JJ
cord-023417-by18aczt	593	23	manner	manner	NN
cord-023417-by18aczt	593	24	,	,	,
cord-023417-by18aczt	593	25	as	as	RB
cord-023417-by18aczt	593	26	long	long	RB
cord-023417-by18aczt	593	27	as	as	IN
cord-023417-by18aczt	593	28	a	a	DT
cord-023417-by18aczt	593	29	proteome	proteome	NN
cord-023417-by18aczt	593	30	can	can	MD
cord-023417-by18aczt	593	31	be	be	VB
cord-023417-by18aczt	593	32	isolated	isolate	VBN
cord-023417-by18aczt	593	33	.	.	.
cord-023417-by18aczt	594	1	However	however	RB
cord-023417-by18aczt	594	2	,	,	,
cord-023417-by18aczt	594	3	the	the	DT
cord-023417-by18aczt	594	4	complexity	complexity	NN
cord-023417-by18aczt	594	5	of	of	IN
cord-023417-by18aczt	594	6	proteomes	proteome	NNS
cord-023417-by18aczt	594	7	,	,	,
cord-023417-by18aczt	594	8	containing	contain	VBG
cord-023417-by18aczt	594	9	several	several	JJ
cord-023417-by18aczt	594	10	thousands	thousand	NNS
cord-023417-by18aczt	594	11	of	of	IN
cord-023417-by18aczt	594	12	different	different	JJ
cord-023417-by18aczt	594	13	proteins	protein	NNS
cord-023417-by18aczt	594	14	,	,	,
cord-023417-by18aczt	594	15	is	be	VBZ
cord-023417-by18aczt	594	16	a	a	DT
cord-023417-by18aczt	594	17	problem	problem	NN
cord-023417-by18aczt	594	18	.	.	.
cord-023417-by18aczt	595	1	Here	here	RB
cord-023417-by18aczt	595	2	,	,	,
cord-023417-by18aczt	595	3	we	-PRON-	PRP
cord-023417-by18aczt	595	4	have	have	VBP
cord-023417-by18aczt	595	5	designed	design	VBN
cord-023417-by18aczt	595	6	antibody	antibody	NN
cord-023417-by18aczt	595	7	microarrays	microarray	NNS
cord-023417-by18aczt	595	8	targeting	target	VBG
cord-023417-by18aczt	595	9	the	the	DT
cord-023417-by18aczt	595	10	water	water	NN
cord-023417-by18aczt	595	11	-	-	HYPH
cord-023417-by18aczt	595	12	soluble	soluble	JJ
cord-023417-by18aczt	595	13	fraction	fraction	NN
cord-023417-by18aczt	595	14	of	of	IN
cord-023417-by18aczt	595	15	a	a	DT
cord-023417-by18aczt	595	16	proteome	proteome	NN
cord-023417-by18aczt	595	17	.	.	.
cord-023417-by18aczt	596	1	To	to	IN
cord-023417-by18aczt	596	2	this	this	DT
cord-023417-by18aczt	596	3	end	end	NN
cord-023417-by18aczt	596	4	,	,	,
cord-023417-by18aczt	596	5	an	an	DT
cord-023417-by18aczt	596	6	anticytokine	anticytokine	JJ
cord-023417-by18aczt	596	7	antibody	antibody	NN
cord-023417-by18aczt	596	8	array	array	NN
cord-023417-by18aczt	596	9	was	be	VBD
cord-023417-by18aczt	596	10	developed	develop	VBN
cord-023417-by18aczt	596	11	and	and	CC
cord-023417-by18aczt	596	12	human	human	JJ
cord-023417-by18aczt	596	13	dendritic	dendritic	JJ
cord-023417-by18aczt	596	14	cells	cell	NNS
cord-023417-by18aczt	596	15	(	(	-LRB-
cord-023417-by18aczt	596	16	AEactivation	AEactivation	NNP
cord-023417-by18aczt	596	17	)	)	-RRB-
cord-023417-by18aczt	596	18	was	be	VBD
cord-023417-by18aczt	596	19	used	use	VBN
cord-023417-by18aczt	596	20	as	as	IN
cord-023417-by18aczt	596	21	model	model	NN
cord-023417-by18aczt	596	22	system	system	NN
cord-023417-by18aczt	596	23	.	.	.
cord-023417-by18aczt	597	1	The	the	DT
cord-023417-by18aczt	597	2	results	result	NNS
cord-023417-by18aczt	597	3	showed	show	VBD
cord-023417-by18aczt	597	4	that	that	IN
cord-023417-by18aczt	597	5	our	-PRON-	PRP$
cord-023417-by18aczt	597	6	antibody	antibody	NN
cord-023417-by18aczt	597	7	microarrays	microarray	NNS
cord-023417-by18aczt	597	8	could	could	MD
cord-023417-by18aczt	597	9	be	be	VB
cord-023417-by18aczt	597	10	used	use	VBN
cord-023417-by18aczt	597	11	to	to	TO
cord-023417-by18aczt	597	12	examine	examine	VB
cord-023417-by18aczt	597	13	the	the	DT
cord-023417-by18aczt	597	14	cytokine	cytokine	NN
cord-023417-by18aczt	597	15	profile	profile	NN
cord-023417-by18aczt	597	16	in	in	IN
cord-023417-by18aczt	597	17	complex	complex	JJ
cord-023417-by18aczt	597	18	samples	sample	NNS
cord-023417-by18aczt	597	19	.	.	.
cord-023417-by18aczt	598	1	Furthermore	furthermore	RB
cord-023417-by18aczt	598	2	,	,	,
cord-023417-by18aczt	598	3	we	-PRON-	PRP
cord-023417-by18aczt	598	4	have	have	VBP
cord-023417-by18aczt	598	5	taken	take	VBN
cord-023417-by18aczt	598	6	the	the	DT
cord-023417-by18aczt	598	7	first	first	JJ
cord-023417-by18aczt	598	8	steps	step	NNS
cord-023417-by18aczt	598	9	towards	towards	IN
cord-023417-by18aczt	598	10	comparing	compare	VBG
cord-023417-by18aczt	598	11	our	-PRON-	PRP$
cord-023417-by18aczt	598	12	results	result	NNS
cord-023417-by18aczt	598	13	with	with	IN
cord-023417-by18aczt	598	14	those	those	DT
cord-023417-by18aczt	598	15	of	of	IN
cord-023417-by18aczt	598	16	other	other	JJ
cord-023417-by18aczt	598	17	technologies	technology	NNS
cord-023417-by18aczt	598	18	on	on	IN
cord-023417-by18aczt	598	19	both	both	CC
cord-023417-by18aczt	598	20	the	the	DT
cord-023417-by18aczt	598	21	protein	protein	NN
cord-023417-by18aczt	598	22	and	and	CC
cord-023417-by18aczt	598	23	gene	gene	NN
cord-023417-by18aczt	598	24	level	level	NN
cord-023417-by18aczt	598	25	.	.	.
cord-023417-by18aczt	599	1	Due	due	IN
cord-023417-by18aczt	599	2	to	to	IN
cord-023417-by18aczt	599	3	the	the	DT
cord-023417-by18aczt	599	4	complexity	complexity	NN
cord-023417-by18aczt	599	5	of	of	IN
cord-023417-by18aczt	599	6	the	the	DT
cord-023417-by18aczt	599	7	model	model	NN
cord-023417-by18aczt	599	8	proteome	proteome	NN
cord-023417-by18aczt	599	9	,	,	,
cord-023417-by18aczt	599	10	we	-PRON-	PRP
cord-023417-by18aczt	599	11	also	also	RB
cord-023417-by18aczt	599	12	examined	examine	VBD
cord-023417-by18aczt	599	13	the	the	DT
cord-023417-by18aczt	599	14	possibility	possibility	NN
cord-023417-by18aczt	599	15	to	to	TO
cord-023417-by18aczt	599	16	prefractionate	prefractionate	VB
cord-023417-by18aczt	599	17	the	the	DT
cord-023417-by18aczt	599	18	proteome	proteome	NN
cord-023417-by18aczt	599	19	in	in	IN
cord-023417-by18aczt	599	20	a	a	DT
cord-023417-by18aczt	599	21	simple	simple	JJ
cord-023417-by18aczt	599	22	one	one	CD
cord-023417-by18aczt	599	23	-	-	HYPH
cord-023417-by18aczt	599	24	step	step	NN
cord-023417-by18aczt	599	25	procedure	procedure	NN
cord-023417-by18aczt	599	26	(	(	-LRB-
cord-023417-by18aczt	599	27	based	base	VBN
cord-023417-by18aczt	599	28	on	on	IN
cord-023417-by18aczt	599	29	size	size	NN
cord-023417-by18aczt	599	30	)	)	-RRB-
cord-023417-by18aczt	599	31	prior	prior	RB
cord-023417-by18aczt	599	32	to	to	IN
cord-023417-by18aczt	599	33	the	the	DT
cord-023417-by18aczt	599	34	labelling	labelling	NN
cord-023417-by18aczt	599	35	step	step	NN
cord-023417-by18aczt	599	36	.	.	.
cord-023417-by18aczt	600	1	In	in	IN
cord-023417-by18aczt	600	2	more	more	JJR
cord-023417-by18aczt	600	3	detail	detail	NN
cord-023417-by18aczt	600	4	,	,	,
cord-023417-by18aczt	600	5	the	the	DT
cord-023417-by18aczt	600	6	sample	sample	NN
cord-023417-by18aczt	600	7	proteome	proteome	NN
cord-023417-by18aczt	600	8	was	be	VBD
cord-023417-by18aczt	600	9	fractionated	fractionate	VBN
cord-023417-by18aczt	600	10	into	into	IN
cord-023417-by18aczt	600	11	two	two	CD
cord-023417-by18aczt	600	12	fractions	fraction	NNS
cord-023417-by18aczt	600	13	using	use	VBG
cord-023417-by18aczt	600	14	membrane	membrane	NN
cord-023417-by18aczt	600	15	devices	device	NNS
cord-023417-by18aczt	600	16	with	with	IN
cord-023417-by18aczt	600	17	different	different	JJ
cord-023417-by18aczt	600	18	molecular	molecular	JJ
cord-023417-by18aczt	600	19	weight	weight	NN
cord-023417-by18aczt	600	20	cut	cut	NN
cord-023417-by18aczt	600	21	-	-	HYPH
cord-023417-by18aczt	600	22	offs	off	NNS
cord-023417-by18aczt	600	23	.	.	.
cord-023417-by18aczt	601	1	The	the	DT
cord-023417-by18aczt	601	2	results	result	NNS
cord-023417-by18aczt	601	3	showed	show	VBD
cord-023417-by18aczt	601	4	that	that	IN
cord-023417-by18aczt	601	5	the	the	DT
cord-023417-by18aczt	601	6	fractionation	fractionation	NN
cord-023417-by18aczt	601	7	considerably	considerably	RB
cord-023417-by18aczt	601	8	enhanced	enhance	VBD
cord-023417-by18aczt	601	9	the	the	DT
cord-023417-by18aczt	601	10	assay	assay	NN
cord-023417-by18aczt	601	11	sensitivity	sensitivity	NN
cord-023417-by18aczt	601	12	allowing	allow	VBG
cord-023417-by18aczt	601	13	cytokines	cytokine	NNS
cord-023417-by18aczt	601	14	in	in	IN
cord-023417-by18aczt	601	15	the	the	DT
cord-023417-by18aczt	601	16	pg	pg	NN
cord-023417-by18aczt	601	17	/	/	SYM
cord-023417-by18aczt	601	18	ml	ml	NN
cord-023417-by18aczt	601	19	range	range	NN
cord-023417-by18aczt	601	20	to	to	TO
cord-023417-by18aczt	601	21	be	be	VB
cord-023417-by18aczt	601	22	readily	readily	RB
cord-023417-by18aczt	601	23	detectable	detectable	JJ
cord-023417-by18aczt	601	24	.	.	.
cord-023417-by18aczt	602	1	The	the	DT
cord-023417-by18aczt	602	2	Immunomodulatory	Immunomodulatory	NNP
cord-023417-by18aczt	602	3	Effect	Effect	NNP
cord-023417-by18aczt	602	4	of	of	IN
cord-023417-by18aczt	602	5	Heat	Heat	NNP
cord-023417-by18aczt	602	6	Shock	Shock	NNP
cord-023417-by18aczt	602	7	Protein	Protein	NNP
cord-023417-by18aczt	602	8	70	70	CD
cord-023417-by18aczt	602	9	:	:	:
cord-023417-by18aczt	602	10	Immunization	immunization	NN
cord-023417-by18aczt	602	11	with	with	IN
cord-023417-by18aczt	602	12	a	a	DT
cord-023417-by18aczt	602	13	DNA	dna	NN
cord-023417-by18aczt	602	14	Construct	construct	NN
cord-023417-by18aczt	602	15	Based	base	VBN
cord-023417-by18aczt	602	16	on	on	IN
cord-023417-by18aczt	602	17	the	the	DT
cord-023417-by18aczt	602	18	Malarial	Malarial	NNP
cord-023417-by18aczt	602	19	Antigen	Antigen	NNP
cord-023417-by18aczt	602	20	Fused	fuse	VBN
cord-023417-by18aczt	602	21	with	with	IN
cord-023417-by18aczt	602	22	a	a	DT
cord-023417-by18aczt	602	23	Fragment	Fragment	NNP
cord-023417-by18aczt	602	24	of	of	IN
cord-023417-by18aczt	602	25	HSP	HSP	NNP
cord-023417-by18aczt	602	26	70	70	CD
cord-023417-by18aczt	602	27	Primes	Primes	NNPS
cord-023417-by18aczt	602	28	for	for	IN
cord-023417-by18aczt	602	29	a	a	DT
cord-023417-by18aczt	602	30	Th-1	Th-1	NNP
cord-023417-by18aczt	602	31	Type	Type	NNP
cord-023417-by18aczt	602	32	of	of	IN
cord-023417-by18aczt	602	33	Response	Response	NNP
cord-023417-by18aczt	602	34	Finding	find	VBG
cord-023417-by18aczt	602	35	an	an	DT
cord-023417-by18aczt	602	36	appropriate	appropriate	JJ
cord-023417-by18aczt	602	37	adjuvant	adjuvant	NN
cord-023417-by18aczt	602	38	for	for	IN
cord-023417-by18aczt	602	39	human	human	JJ
cord-023417-by18aczt	602	40	vaccination	vaccination	NN
cord-023417-by18aczt	602	41	is	be	VBZ
cord-023417-by18aczt	602	42	crucial	crucial	JJ
cord-023417-by18aczt	602	43	.	.	.
cord-023417-by18aczt	603	1	Heat	heat	NN
cord-023417-by18aczt	603	2	shock	shock	NN
cord-023417-by18aczt	603	3	proteins	protein	NNS
cord-023417-by18aczt	603	4	(	(	-LRB-
cord-023417-by18aczt	603	5	HSPs	HSPs	NNP
cord-023417-by18aczt	603	6	)	)	-RRB-
cord-023417-by18aczt	603	7	act	act	VBP
cord-023417-by18aczt	603	8	as	as	IN
cord-023417-by18aczt	603	9	adjuvants	adjuvant	NNS
cord-023417-by18aczt	603	10	when	when	WRB
cord-023417-by18aczt	603	11	coadministered	coadministere	VBN
cord-023417-by18aczt	603	12	with	with	IN
cord-023417-by18aczt	603	13	peptide	peptide	NN
cord-023417-by18aczt	603	14	antigens	antigen	NNS
cord-023417-by18aczt	603	15	or	or	CC
cord-023417-by18aczt	603	16	given	give	VBN
cord-023417-by18aczt	603	17	as	as	IN
cord-023417-by18aczt	603	18	fusion	fusion	NN
cord-023417-by18aczt	603	19	proteins	protein	NNS
cord-023417-by18aczt	603	20	.	.	.
cord-023417-by18aczt	604	1	However	however	RB
cord-023417-by18aczt	604	2	,	,	,
cord-023417-by18aczt	604	3	there	there	EX
cord-023417-by18aczt	604	4	is	be	VBZ
cord-023417-by18aczt	604	5	a	a	DT
cord-023417-by18aczt	604	6	potential	potential	JJ
cord-023417-by18aczt	604	7	risk	risk	NN
cord-023417-by18aczt	604	8	of	of	IN
cord-023417-by18aczt	604	9	autoimmunity	autoimmunity	NN
cord-023417-by18aczt	604	10	when	when	WRB
cord-023417-by18aczt	604	11	using	use	VBG
cord-023417-by18aczt	604	12	the	the	DT
cord-023417-by18aczt	604	13	complete	complete	JJ
cord-023417-by18aczt	604	14	molecules	molecule	NNS
cord-023417-by18aczt	604	15	,	,	,
cord-023417-by18aczt	604	16	because	because	IN
cord-023417-by18aczt	604	17	HSPs	hsp	NNS
cord-023417-by18aczt	604	18	are	be	VBP
cord-023417-by18aczt	604	19	evolutionary	evolutionary	JJ
cord-023417-by18aczt	604	20	conserved	conserve	VBN
cord-023417-by18aczt	604	21	.	.	.
cord-023417-by18aczt	605	1	To	to	TO
cord-023417-by18aczt	605	2	overcome	overcome	VB
cord-023417-by18aczt	605	3	this	this	DT
cord-023417-by18aczt	605	4	,	,	,
cord-023417-by18aczt	605	5	we	-PRON-	PRP
cord-023417-by18aczt	605	6	first	first	RB
cord-023417-by18aczt	605	7	evaluated	evaluate	VBD
cord-023417-by18aczt	605	8	the	the	DT
cord-023417-by18aczt	605	9	adjuvant	adjuvant	JJ
cord-023417-by18aczt	605	10	effect	effect	NN
cord-023417-by18aczt	605	11	against	against	IN
cord-023417-by18aczt	605	12	two	two	CD
cord-023417-by18aczt	605	13	different	different	JJ
cord-023417-by18aczt	605	14	antigens	antigen	NNS
cord-023417-by18aczt	605	15	of	of	IN
cord-023417-by18aczt	605	16	a	a	DT
cord-023417-by18aczt	605	17	less	less	RBR
cord-023417-by18aczt	605	18	-	-	HYPH
cord-023417-by18aczt	605	19	conserved	conserve	VBN
cord-023417-by18aczt	605	20	fraction	fraction	NN
cord-023417-by18aczt	605	21	of	of	IN
cord-023417-by18aczt	605	22	Plasmodium	plasmodium	NN
cord-023417-by18aczt	605	23	falciparum	falciparum	NN
cord-023417-by18aczt	605	24	HSP70	HSP70	NNP
cord-023417-by18aczt	605	25	(	(	-LRB-
cord-023417-by18aczt	605	26	Pf70C	Pf70C	NNP
cord-023417-by18aczt	605	27	)	)	-RRB-
cord-023417-by18aczt	605	28	and	and	CC
cord-023417-by18aczt	605	29	compared	compare	VBD
cord-023417-by18aczt	605	30	it	-PRON-	PRP
cord-023417-by18aczt	605	31	to	to	IN
cord-023417-by18aczt	605	32	the	the	DT
cord-023417-by18aczt	605	33	whole	whole	JJ
cord-023417-by18aczt	605	34	HSP70	HSP70	NNP
cord-023417-by18aczt	605	35	molecule	molecule	NN
cord-023417-by18aczt	605	36	from	from	IN
cord-023417-by18aczt	605	37	Trypanosoma	Trypanosoma	NNP
cord-023417-by18aczt	605	38	cruzi	cruzi	NNP
cord-023417-by18aczt	605	39	(	(	-LRB-
cord-023417-by18aczt	605	40	TcHSP70	TcHSP70	NNP
cord-023417-by18aczt	605	41	)	)	-RRB-
cord-023417-by18aczt	605	42	.	.	.
cord-023417-by18aczt	606	1	We	-PRON-	PRP
cord-023417-by18aczt	606	2	found	find	VBD
cord-023417-by18aczt	606	3	that	that	IN
cord-023417-by18aczt	606	4	Pf70C	Pf70C	NNP
cord-023417-by18aczt	606	5	exhibited	exhibit	VBD
cord-023417-by18aczt	606	6	similar	similar	JJ
cord-023417-by18aczt	606	7	adjuvant	adjuvant	JJ
cord-023417-by18aczt	606	8	properties	property	NNS
cord-023417-by18aczt	606	9	as	as	IN
cord-023417-by18aczt	606	10	the	the	DT
cord-023417-by18aczt	606	11	whole	whole	JJ
cord-023417-by18aczt	606	12	molecule	molecule	NN
cord-023417-by18aczt	606	13	.	.	.
cord-023417-by18aczt	607	1	We	-PRON-	PRP
cord-023417-by18aczt	607	2	later	later	RB
cord-023417-by18aczt	607	3	evaluated	evaluate	VBD
cord-023417-by18aczt	607	4	the	the	DT
cord-023417-by18aczt	607	5	adjuvant	adjuvant	JJ
cord-023417-by18aczt	607	6	potential	potential	NN
cord-023417-by18aczt	607	7	of	of	IN
cord-023417-by18aczt	607	8	Pf70C	Pf70C	NNP
cord-023417-by18aczt	607	9	against	against	IN
cord-023417-by18aczt	607	10	the	the	DT
cord-023417-by18aczt	607	11	malarial	malarial	JJ
cord-023417-by18aczt	607	12	antigen	antigen	NN
cord-023417-by18aczt	608	1	EB200	eb200	UH
cord-023417-by18aczt	608	2	in	in	IN
cord-023417-by18aczt	608	3	a	a	DT
cord-023417-by18aczt	608	4	chimeric	chimeric	JJ
cord-023417-by18aczt	608	5	DNA	dna	NN
cord-023417-by18aczt	608	6	construct	construct	NN
cord-023417-by18aczt	608	7	.	.	.
cord-023417-by18aczt	609	1	No	no	DT
cord-023417-by18aczt	609	2	appreciable	appreciable	JJ
cord-023417-by18aczt	609	3	levels	level	NNS
cord-023417-by18aczt	609	4	of	of	IN
cord-023417-by18aczt	609	5	EB200-specific	EB200-specific	NNP
cord-023417-by18aczt	609	6	Abstracts	abstract	NNS
cord-023417-by18aczt	609	7	629	629	CD
cord-023417-by18aczt	609	8	..................................................................................................................................................................................................	..................................................................................................................................................................................................	.
cord-023417-by18aczt	610	1	antibodies	antibody	NNS
cord-023417-by18aczt	610	2	were	be	VBD
cord-023417-by18aczt	610	3	detected	detect	VBN
cord-023417-by18aczt	610	4	in	in	IN
cord-023417-by18aczt	610	5	mice	mouse	NNS
cord-023417-by18aczt	610	6	immunized	immunize	VBN
cord-023417-by18aczt	610	7	only	only	RB
cord-023417-by18aczt	610	8	with	with	IN
cord-023417-by18aczt	610	9	the	the	DT
cord-023417-by18aczt	610	10	DNA	dna	NN
cord-023417-by18aczt	610	11	constructs	construct	NNS
cord-023417-by18aczt	610	12	.	.	.
cord-023417-by18aczt	611	1	However	however	RB
cord-023417-by18aczt	611	2	,	,	,
cord-023417-by18aczt	611	3	DNA	DNA	NNP
cord-023417-by18aczt	611	4	primed	prime	VBD
cord-023417-by18aczt	611	5	the	the	DT
cord-023417-by18aczt	611	6	immune	immune	JJ
cord-023417-by18aczt	611	7	system	system	NN
cord-023417-by18aczt	611	8	,	,	,
cord-023417-by18aczt	611	9	because	because	IN
cord-023417-by18aczt	611	10	subsequent	subsequent	JJ
cord-023417-by18aczt	611	11	challenge	challenge	NN
cord-023417-by18aczt	611	12	with	with	IN
cord-023417-by18aczt	611	13	the	the	DT
cord-023417-by18aczt	611	14	corresponding	corresponding	JJ
cord-023417-by18aczt	611	15	recombinant	recombinant	JJ
cord-023417-by18aczt	611	16	fusion	fusion	NN
cord-023417-by18aczt	611	17	proteins	protein	NNS
cord-023417-by18aczt	611	18	elicited	elicit	VBD
cord-023417-by18aczt	611	19	a	a	DT
cord-023417-by18aczt	611	20	strong	strong	JJ
cord-023417-by18aczt	611	21	Th-1	Th-1	NNP
cord-023417-by18aczt	611	22	antibody	antibody	NN
cord-023417-by18aczt	611	23	response	response	NN
cord-023417-by18aczt	611	24	.	.	.
cord-023417-by18aczt	612	1	In	in	IN
cord-023417-by18aczt	612	2	contrast	contrast	NN
cord-023417-by18aczt	612	3	,	,	,
cord-023417-by18aczt	612	4	no	no	DT
cord-023417-by18aczt	612	5	priming	priming	NN
cord-023417-by18aczt	612	6	effect	effect	NN
cord-023417-by18aczt	612	7	was	be	VBD
cord-023417-by18aczt	612	8	observed	observe	VBN
cord-023417-by18aczt	612	9	for	for	IN
cord-023417-by18aczt	612	10	ex	ex	FW
cord-023417-by18aczt	612	11	vivo	vivo	NNP
cord-023417-by18aczt	612	12	IFN	IFN	NNP
cord-023417-by18aczt	612	13	-	-	HYPH
cord-023417-by18aczt	612	14	g	g	NN
cord-023417-by18aczt	612	15	production	production	NN
cord-023417-by18aczt	612	16	but	but	CC
cord-023417-by18aczt	612	17	stimulation	stimulation	NN
cord-023417-by18aczt	612	18	with	with	IN
cord-023417-by18aczt	612	19	the	the	DT
cord-023417-by18aczt	612	20	HSP	HSP	NNP
cord-023417-by18aczt	612	21	-	-	HYPH
cord-023417-by18aczt	612	22	chimeric	chimeric	JJ
cord-023417-by18aczt	612	23	fusion	fusion	NN
cord-023417-by18aczt	612	24	protein	protein	NN
cord-023417-by18aczt	612	25	induced	induce	VBD
cord-023417-by18aczt	612	26	a	a	DT
cord-023417-by18aczt	612	27	stronger	strong	JJR
cord-023417-by18aczt	612	28	secretion	secretion	NN
cord-023417-by18aczt	612	29	of	of	IN
cord-023417-by18aczt	612	30	IFN	IFN	NNP
cord-023417-by18aczt	612	31	-	-	HYPH
cord-023417-by18aczt	612	32	g	g	NNP
cord-023417-by18aczt	612	33	in	in	IN
cord-023417-by18aczt	612	34	vitro	vitro	FW
cord-023417-by18aczt	612	35	than	than	IN
cord-023417-by18aczt	612	36	other	other	JJ
cord-023417-by18aczt	612	37	proteins	protein	NNS
cord-023417-by18aczt	612	38	used	use	VBN
cord-023417-by18aczt	612	39	.	.	.
cord-023417-by18aczt	613	1	These	these	DT
cord-023417-by18aczt	613	2	results	result	NNS
cord-023417-by18aczt	613	3	indicate	indicate	VBP
cord-023417-by18aczt	613	4	that	that	IN
cord-023417-by18aczt	613	5	the	the	DT
cord-023417-by18aczt	613	6	use	use	NN
cord-023417-by18aczt	613	7	of	of	IN
cord-023417-by18aczt	613	8	HSPs	HSPs	NNP
cord-023417-by18aczt	613	9	is	be	VBZ
cord-023417-by18aczt	613	10	promising	promise	VBG
cord-023417-by18aczt	613	11	in	in	IN
cord-023417-by18aczt	613	12	the	the	DT
cord-023417-by18aczt	613	13	design	design	NN
cord-023417-by18aczt	613	14	of	of	IN
cord-023417-by18aczt	613	15	new	new	JJ
cord-023417-by18aczt	613	16	vaccines	vaccine	NNS
cord-023417-by18aczt	613	17	.	.	.
cord-023417-by18aczt	614	1	High	High	NNP
cord-023417-by18aczt	614	2	-	-	HYPH
cord-023417-by18aczt	614	3	Throughput	Throughput	NNP
cord-023417-by18aczt	614	4	Proteomics	Proteomics	NNP
cord-023417-by18aczt	614	5	on	on	IN
cord-023417-by18aczt	614	6	Antibody	Antibody	NNP
cord-023417-by18aczt	614	7	-	-	HYPH
cord-023417-by18aczt	614	8	based	base	VBN
cord-023417-by18aczt	614	9	Microarrays	microarray	NNS
cord-023417-by18aczt	614	10	:	:	:
cord-023417-by18aczt	614	11	the	the	DT
cord-023417-by18aczt	614	12	Importance	Importance	NNP
cord-023417-by18aczt	614	13	of	of	IN
cord-023417-by18aczt	614	14	Probe	Probe	NNP
cord-023417-by18aczt	614	15	and	and	CC
cord-023417-by18aczt	614	16	Surface	Surface	NNP
cord-023417-by18aczt	614	17	Design	Design	NNP
cord-023417-by18aczt	615	1	In	in	IN
cord-023417-by18aczt	615	2	analogy	analogy	NN
cord-023417-by18aczt	615	3	to	to	IN
cord-023417-by18aczt	615	4	DNA	dna	NN
cord-023417-by18aczt	615	5	microarrays	microarray	NNS
cord-023417-by18aczt	615	6	,	,	,
cord-023417-by18aczt	615	7	protein	protein	NN
cord-023417-by18aczt	615	8	microarrays	microarray	NNS
cord-023417-by18aczt	615	9	offer	offer	VBP
cord-023417-by18aczt	615	10	a	a	DT
cord-023417-by18aczt	615	11	new	new	JJ
cord-023417-by18aczt	615	12	distinct	distinct	JJ
cord-023417-by18aczt	615	13	possibility	possibility	NN
cord-023417-by18aczt	615	14	to	to	TO
cord-023417-by18aczt	615	15	perform	perform	VB
cord-023417-by18aczt	615	16	sensitive	sensitive	JJ
cord-023417-by18aczt	615	17	highthroughput	highthroughput	NN
cord-023417-by18aczt	615	18	global	global	JJ
cord-023417-by18aczt	615	19	proteome	proteome	NN
cord-023417-by18aczt	615	20	analysis	analysis	NN
cord-023417-by18aczt	615	21	.	.	.
cord-023417-by18aczt	616	1	However	however	RB
cord-023417-by18aczt	616	2	,	,	,
cord-023417-by18aczt	616	3	the	the	DT
cord-023417-by18aczt	616	4	development	development	NN
cord-023417-by18aczt	616	5	of	of	IN
cord-023417-by18aczt	616	6	the	the	DT
cord-023417-by18aczt	616	7	protein	protein	NN
cord-023417-by18aczt	616	8	microarray	microarray	NN
cord-023417-by18aczt	616	9	technology	technology	NN
cord-023417-by18aczt	616	10	will	will	MD
cord-023417-by18aczt	616	11	place	place	VB
cord-023417-by18aczt	616	12	high	high	JJ
cord-023417-by18aczt	616	13	demands	demand	NNS
cord-023417-by18aczt	616	14	upon	upon	IN
cord-023417-by18aczt	616	15	the	the	DT
cord-023417-by18aczt	616	16	design	design	NN
cord-023417-by18aczt	616	17	of	of	IN
cord-023417-by18aczt	616	18	both	both	DT
cord-023417-by18aczt	616	19	probes	probe	NNS
cord-023417-by18aczt	616	20	and	and	CC
cord-023417-by18aczt	616	21	solid	solid	JJ
cord-023417-by18aczt	616	22	supports	support	NNS
cord-023417-by18aczt	616	23	.	.	.
cord-023417-by18aczt	617	1	The	the	DT
cord-023417-by18aczt	617	2	analysis	analysis	NN
cord-023417-by18aczt	617	3	of	of	IN
cord-023417-by18aczt	617	4	thousands	thousand	NNS
cord-023417-by18aczt	617	5	of	of	IN
cord-023417-by18aczt	617	6	heterogeneous	heterogeneous	JJ
cord-023417-by18aczt	617	7	proteins	protein	NNS
cord-023417-by18aczt	617	8	on	on	IN
cord-023417-by18aczt	617	9	a	a	DT
cord-023417-by18aczt	617	10	single	single	JJ
cord-023417-by18aczt	617	11	microarray	microarray	NN
cord-023417-by18aczt	617	12	requires	require	VBZ
cord-023417-by18aczt	617	13	the	the	DT
cord-023417-by18aczt	617	14	use	use	NN
cord-023417-by18aczt	617	15	of	of	IN
cord-023417-by18aczt	617	16	uniform	uniform	JJ
cord-023417-by18aczt	617	17	probes	probe	NNS
cord-023417-by18aczt	617	18	,	,	,
cord-023417-by18aczt	617	19	such	such	JJ
cord-023417-by18aczt	617	20	as	as	IN
cord-023417-by18aczt	617	21	antibodies	antibody	NNS
cord-023417-by18aczt	617	22	,	,	,
cord-023417-by18aczt	617	23	directly	directly	RB
cord-023417-by18aczt	617	24	designed	design	VBN
cord-023417-by18aczt	617	25	for	for	IN
cord-023417-by18aczt	617	26	protein	protein	NN
cord-023417-by18aczt	617	27	microarray	microarray	NN
cord-023417-by18aczt	617	28	applications	application	NNS
cord-023417-by18aczt	617	29	.	.	.
cord-023417-by18aczt	618	1	We	-PRON-	PRP
cord-023417-by18aczt	618	2	have	have	VBP
cord-023417-by18aczt	618	3	recently	recently	RB
cord-023417-by18aczt	618	4	generated	generate	VBN
cord-023417-by18aczt	618	5	a	a	DT
cord-023417-by18aczt	618	6	human	human	JJ
cord-023417-by18aczt	618	7	recombinant	recombinant	JJ
cord-023417-by18aczt	618	8	single	single	JJ
cord-023417-by18aczt	618	9	-	-	HYPH
cord-023417-by18aczt	618	10	chain	chain	NN
cord-023417-by18aczt	618	11	Fv	Fv	NNP
cord-023417-by18aczt	618	12	antibody	antibody	NN
cord-023417-by18aczt	618	13	library	library	NN
cord-023417-by18aczt	618	14	,	,	,
cord-023417-by18aczt	618	15	genetically	genetically	RB
cord-023417-by18aczt	618	16	constructed	construct	VBN
cord-023417-by18aczt	618	17	around	around	IN
cord-023417-by18aczt	618	18	one	one	CD
cord-023417-by18aczt	618	19	framework	framework	NN
cord-023417-by18aczt	618	20	,	,	,
cord-023417-by18aczt	618	21	the	the	DT
cord-023417-by18aczt	618	22	nCoDeR	nCoDeR	NNP
cord-023417-by18aczt	618	23	-	-	HYPH
cord-023417-by18aczt	618	24	library	library	NN
cord-023417-by18aczt	618	25	,	,	,
cord-023417-by18aczt	618	26	containing	contain	VBG
cord-023417-by18aczt	618	27	2	2	CD
cord-023417-by18aczt	618	28	Â	â	CD
cord-023417-by18aczt	618	29	1010	1010	CD
cord-023417-by18aczt	618	30	clones	clone	NNS
cord-023417-by18aczt	618	31	.	.	.
cord-023417-by18aczt	619	1	Single	single	JJ
cord-023417-by18aczt	619	2	framework	framework	NN
cord-023417-by18aczt	619	3	antibody	antibody	NN
cord-023417-by18aczt	619	4	fragments	fragment	NNS
cord-023417-by18aczt	619	5	(	(	-LRB-
cord-023417-by18aczt	619	6	sinFabs	sinFabs	NFP
cord-023417-by18aczt	619	7	)	)	-RRB-
cord-023417-by18aczt	619	8	selected	select	VBN
cord-023417-by18aczt	619	9	from	from	IN
cord-023417-by18aczt	619	10	this	this	DT
cord-023417-by18aczt	619	11	library	library	NN
cord-023417-by18aczt	619	12	were	be	VBD
cord-023417-by18aczt	619	13	successfully	successfully	RB
cord-023417-by18aczt	619	14	applied	apply	VBN
cord-023417-by18aczt	619	15	as	as	IN
cord-023417-by18aczt	619	16	probes	probe	NNS
cord-023417-by18aczt	619	17	for	for	IN
cord-023417-by18aczt	619	18	microarrays	microarray	NNS
cord-023417-by18aczt	619	19	providing	provide	VBG
cord-023417-by18aczt	619	20	sensitive	sensitive	JJ
cord-023417-by18aczt	619	21	detection	detection	NN
cord-023417-by18aczt	619	22	in	in	IN
cord-023417-by18aczt	619	23	the	the	DT
cord-023417-by18aczt	619	24	600	600	CD
cord-023417-by18aczt	619	25	attomol	attomol	JJ
cord-023417-by18aczt	619	26	(	(	-LRB-
cord-023417-by18aczt	619	27	mass	mass	NNP
cord-023417-by18aczt	619	28	spectrometry	spectrometry	NNP
cord-023417-by18aczt	619	29	)	)	-RRB-
cord-023417-by18aczt	619	30	and	and	CC
cord-023417-by18aczt	619	31	the	the	DT
cord-023417-by18aczt	619	32	300	300	CD
cord-023417-by18aczt	619	33	zeptomole	zeptomole	NN
cord-023417-by18aczt	619	34	range	range	NN
cord-023417-by18aczt	619	35	(	(	-LRB-
cord-023417-by18aczt	619	36	fluorescence	fluorescence	NN
cord-023417-by18aczt	619	37	)	)	-RRB-
cord-023417-by18aczt	619	38	.	.	.
cord-023417-by18aczt	620	1	However	however	RB
cord-023417-by18aczt	620	2	,	,	,
cord-023417-by18aczt	620	3	the	the	DT
cord-023417-by18aczt	620	4	choice	choice	NN
cord-023417-by18aczt	620	5	of	of	IN
cord-023417-by18aczt	620	6	framework	framework	NN
cord-023417-by18aczt	620	7	is	be	VBZ
cord-023417-by18aczt	620	8	critical	critical	JJ
cord-023417-by18aczt	620	9	.	.	.
cord-023417-by18aczt	621	1	We	-PRON-	PRP
cord-023417-by18aczt	621	2	have	have	VBP
cord-023417-by18aczt	621	3	shown	show	VBN
cord-023417-by18aczt	621	4	that	that	IN
cord-023417-by18aczt	621	5	the	the	DT
cord-023417-by18aczt	621	6	selected	selected	JJ
cord-023417-by18aczt	621	7	nCoDeR	nCoDeR	NNP
cord-023417-by18aczt	621	8	framework	framework	NN
cord-023417-by18aczt	621	9	displayed	display	VBD
cord-023417-by18aczt	621	10	excellent	excellent	JJ
cord-023417-by18aczt	621	11	functional	functional	JJ
cord-023417-by18aczt	621	12	on	on	IN
cord-023417-by18aczt	621	13	-	-	HYPH
cord-023417-by18aczt	621	14	chip	chip	NN
cord-023417-by18aczt	621	15	stability	stability	NN
cord-023417-by18aczt	621	16	and	and	CC
cord-023417-by18aczt	621	17	arrayed	array	VBD
cord-023417-by18aczt	621	18	dehydrated	dehydrated	JJ
cord-023417-by18aczt	621	19	probes	probe	NNS
cord-023417-by18aczt	621	20	retained	retain	VBD
cord-023417-by18aczt	621	21	their	-PRON-	PRP$
cord-023417-by18aczt	621	22	activity	activity	NN
cord-023417-by18aczt	621	23	for	for	IN
cord-023417-by18aczt	621	24	several	several	JJ
cord-023417-by18aczt	621	25	months	month	NNS
cord-023417-by18aczt	621	26	.	.	.
cord-023417-by18aczt	622	1	Furthermore	furthermore	RB
cord-023417-by18aczt	622	2	,	,	,
cord-023417-by18aczt	622	3	we	-PRON-	PRP
cord-023417-by18aczt	622	4	have	have	VBP
cord-023417-by18aczt	622	5	addressed	address	VBN
cord-023417-by18aczt	622	6	the	the	DT
cord-023417-by18aczt	622	7	issues	issue	NNS
cord-023417-by18aczt	622	8	of	of	IN
cord-023417-by18aczt	622	9	biocompatibility	biocompatibility	NN
cord-023417-by18aczt	622	10	of	of	IN
cord-023417-by18aczt	622	11	the	the	DT
cord-023417-by18aczt	622	12	solid	solid	JJ
cord-023417-by18aczt	622	13	support	support	NN
cord-023417-by18aczt	622	14	and	and	CC
cord-023417-by18aczt	622	15	immobilization	immobilization	NN
cord-023417-by18aczt	622	16	strategies	strategy	NNS
cord-023417-by18aczt	622	17	for	for	IN
cord-023417-by18aczt	622	18	our	-PRON-	PRP$
cord-023417-by18aczt	622	19	microarray	microarray	NN
cord-023417-by18aczt	622	20	setup	setup	NN
cord-023417-by18aczt	622	21	.	.	.
cord-023417-by18aczt	623	1	An	an	DT
cord-023417-by18aczt	623	2	in	in	IN
cord-023417-by18aczt	623	3	-	-	HYPH
cord-023417-by18aczt	623	4	house	house	NN
cord-023417-by18aczt	623	5	-	-	HYPH
cord-023417-by18aczt	623	6	designed	design	VBN
cord-023417-by18aczt	623	7	substrate	substrate	NN
cord-023417-by18aczt	623	8	,	,	,
cord-023417-by18aczt	623	9	macroporous	macroporous	JJ
cord-023417-by18aczt	623	10	silicon	silicon	NN
cord-023417-by18aczt	623	11	coated	coat	VBN
cord-023417-by18aczt	623	12	with	with	IN
cord-023417-by18aczt	623	13	nitrocellulose	nitrocellulose	NNS
cord-023417-by18aczt	623	14	(	(	-LRB-
cord-023417-by18aczt	623	15	MAP3-NC7	MAP3-NC7	NNP
cord-023417-by18aczt	623	16	)	)	-RRB-
cord-023417-by18aczt	623	17	,	,	,
cord-023417-by18aczt	623	18	displayed	display	VBD
cord-023417-by18aczt	623	19	properties	property	NNS
cord-023417-by18aczt	623	20	equal	equal	JJ
cord-023417-by18aczt	623	21	to	to	IN
cord-023417-by18aczt	623	22	,	,	,
cord-023417-by18aczt	623	23	or	or	CC
cord-023417-by18aczt	623	24	better	well	JJR
cord-023417-by18aczt	623	25	than	than	IN
cord-023417-by18aczt	623	26	,	,	,
cord-023417-by18aczt	623	27	those	those	DT
cord-023417-by18aczt	623	28	of	of	IN
cord-023417-by18aczt	623	29	five	five	CD
cord-023417-by18aczt	623	30	commercially	commercially	RB
cord-023417-by18aczt	623	31	available	available	JJ
cord-023417-by18aczt	623	32	supports	support	NNS
cord-023417-by18aczt	623	33	used	use	VBN
cord-023417-by18aczt	623	34	as	as	IN
cord-023417-by18aczt	623	35	reference	reference	NN
cord-023417-by18aczt	623	36	surfaces	surface	NNS
cord-023417-by18aczt	623	37	.	.	.
cord-023417-by18aczt	624	1	We	-PRON-	PRP
cord-023417-by18aczt	624	2	have	have	VBP
cord-023417-by18aczt	624	3	also	also	RB
cord-023417-by18aczt	624	4	evaluated	evaluate	VBN
cord-023417-by18aczt	624	5	different	different	JJ
cord-023417-by18aczt	624	6	coupling	coupling	NN
cord-023417-by18aczt	624	7	strategies	strategy	NNS
cord-023417-by18aczt	624	8	,	,	,
cord-023417-by18aczt	624	9	such	such	JJ
cord-023417-by18aczt	624	10	as	as	IN
cord-023417-by18aczt	624	11	adsorption	adsorption	NN
cord-023417-by18aczt	624	12	,	,	,
cord-023417-by18aczt	624	13	covalent	covalent	JJ
cord-023417-by18aczt	624	14	coupling	coupling	NN
cord-023417-by18aczt	624	15	,	,	,
cord-023417-by18aczt	624	16	diffusion	diffusion	NN
cord-023417-by18aczt	624	17	and	and	CC
cord-023417-by18aczt	624	18	affinity	affinity	NN
cord-023417-by18aczt	624	19	coupling	coupling	NN
cord-023417-by18aczt	624	20	.	.	.
cord-023417-by18aczt	625	1	Using	use	VBG
cord-023417-by18aczt	625	2	a	a	DT
cord-023417-by18aczt	625	3	novel	novel	JJ
cord-023417-by18aczt	625	4	affinity	affinity	NN
cord-023417-by18aczt	625	5	tag	tag	NN
cord-023417-by18aczt	625	6	,	,	,
cord-023417-by18aczt	625	7	the	the	DT
cord-023417-by18aczt	625	8	double-(his)6-tag	double-(his)6-tag	NN
cord-023417-by18aczt	625	9	,	,	,
cord-023417-by18aczt	625	10	we	-PRON-	PRP
cord-023417-by18aczt	625	11	increased	increase	VBD
cord-023417-by18aczt	625	12	the	the	DT
cord-023417-by18aczt	625	13	binding	binding	JJ
cord-023417-by18aczt	625	14	efficiency	efficiency	NN
cord-023417-by18aczt	625	15	of	of	IN
cord-023417-by18aczt	625	16	sinFab	sinfab	NN
cord-023417-by18aczt	625	17	-	-	HYPH
cord-023417-by18aczt	625	18	molecules	molecule	NNS
cord-023417-by18aczt	625	19	to	to	TO
cord-023417-by18aczt	625	20	Ni2	ni2	VB
cord-023417-by18aczt	625	21	þ	þ	NNP
cord-023417-by18aczt	625	22	-coated	-coated	JJ
cord-023417-by18aczt	625	23	solid	solid	JJ
cord-023417-by18aczt	625	24	supports	support	NNS
cord-023417-by18aczt	625	25	,	,	,
cord-023417-by18aczt	625	26	thereby	thereby	RB
cord-023417-by18aczt	625	27	allowing	allow	VBG
cord-023417-by18aczt	625	28	nonpurified	nonpurifie	VBN
cord-023417-by18aczt	625	29	probes	probe	NNS
cord-023417-by18aczt	625	30	to	to	TO
cord-023417-by18aczt	625	31	be	be	VB
cord-023417-by18aczt	625	32	directly	directly	RB
cord-023417-by18aczt	625	33	applied	apply	VBN
cord-023417-by18aczt	625	34	.	.	.
cord-023417-by18aczt	626	1	The	the	DT
cord-023417-by18aczt	626	2	mannan	mannan	NN
cord-023417-by18aczt	626	3	-	-	HYPH
cord-023417-by18aczt	626	4	binding	bind	VBG
cord-023417-by18aczt	626	5	lectin	lectin	NN
cord-023417-by18aczt	626	6	(	(	-LRB-
cord-023417-by18aczt	626	7	MBL	MBL	NNP
cord-023417-by18aczt	626	8	)	)	-RRB-
cord-023417-by18aczt	626	9	pathway	pathway	NN
cord-023417-by18aczt	626	10	is	be	VBZ
cord-023417-by18aczt	626	11	part	part	NN
cord-023417-by18aczt	626	12	of	of	IN
cord-023417-by18aczt	626	13	the	the	DT
cord-023417-by18aczt	626	14	innate	innate	JJ
cord-023417-by18aczt	626	15	immune	immune	JJ
cord-023417-by18aczt	626	16	system	system	NN
cord-023417-by18aczt	626	17	providing	provide	VBG
cord-023417-by18aczt	626	18	a	a	DT
cord-023417-by18aczt	626	19	first	first	JJ
cord-023417-by18aczt	626	20	line	line	NN
cord-023417-by18aczt	626	21	of	of	IN
cord-023417-by18aczt	626	22	defence	defence	NN
cord-023417-by18aczt	626	23	against	against	IN
cord-023417-by18aczt	626	24	infections	infection	NNS
cord-023417-by18aczt	626	25	.	.	.
cord-023417-by18aczt	627	1	MBL	MBL	NNP
cord-023417-by18aczt	627	2	and	and	CC
cord-023417-by18aczt	627	3	ficolins	ficolin	NNS
cord-023417-by18aczt	627	4	circulate	circulate	VBP
cord-023417-by18aczt	627	5	in	in	IN
cord-023417-by18aczt	627	6	complexes	complex	NNS
cord-023417-by18aczt	627	7	with	with	IN
cord-023417-by18aczt	627	8	MBL	MBL	NNP
cord-023417-by18aczt	627	9	-	-	HYPH
cord-023417-by18aczt	627	10	associated	associate	VBN
cord-023417-by18aczt	627	11	serine	serine	NN
cord-023417-by18aczt	627	12	proteases	protease	NNS
cord-023417-by18aczt	627	13	(	(	-LRB-
cord-023417-by18aczt	627	14	MASP-1	MASP-1	NNP
cord-023417-by18aczt	627	15	,	,	,
cord-023417-by18aczt	627	16	-2	-2	NNP
cord-023417-by18aczt	627	17	and	and	CC
cord-023417-by18aczt	627	18	-3	-3	NNP
cord-023417-by18aczt	627	19	)	)	-RRB-
cord-023417-by18aczt	627	20	.	.	.
cord-023417-by18aczt	628	1	After	after	IN
cord-023417-by18aczt	628	2	recognition	recognition	NN
cord-023417-by18aczt	628	3	of	of	IN
cord-023417-by18aczt	628	4	a	a	DT
cord-023417-by18aczt	628	5	microorganism	microorganism	NN
cord-023417-by18aczt	628	6	by	by	IN
cord-023417-by18aczt	628	7	MBL	MBL	NNP
cord-023417-by18aczt	628	8	,	,	,
cord-023417-by18aczt	628	9	activation	activation	NN
cord-023417-by18aczt	628	10	of	of	IN
cord-023417-by18aczt	628	11	the	the	DT
cord-023417-by18aczt	628	12	complement	complement	JJ
cord-023417-by18aczt	628	13	system	system	NN
cord-023417-by18aczt	628	14	occurs	occur	VBZ
cord-023417-by18aczt	628	15	.	.	.
cord-023417-by18aczt	629	1	MASP-1	MASP-1	NNP
cord-023417-by18aczt	629	2	and	and	CC
cord-023417-by18aczt	629	3	MASP-3	MASP-3	NNP
cord-023417-by18aczt	629	4	share	share	VBP
cord-023417-by18aczt	629	5	five	five	CD
cord-023417-by18aczt	629	6	domains	domain	NNS
cord-023417-by18aczt	629	7	(	(	-LRB-
cord-023417-by18aczt	629	8	making	make	VBG
cord-023417-by18aczt	629	9	up	up	RP
cord-023417-by18aczt	629	10	the	the	DT
cord-023417-by18aczt	629	11	so	so	RB
cord-023417-by18aczt	629	12	-	-	HYPH
cord-023417-by18aczt	629	13	called	call	VBN
cord-023417-by18aczt	629	14	A	a	NN
cord-023417-by18aczt	629	15	-	-	HYPH
cord-023417-by18aczt	629	16	chain	chain	NN
cord-023417-by18aczt	629	17	)	)	-RRB-
cord-023417-by18aczt	629	18	,	,	,
cord-023417-by18aczt	629	19	whereas	whereas	IN
cord-023417-by18aczt	629	20	they	-PRON-	PRP
cord-023417-by18aczt	629	21	have	have	VBP
cord-023417-by18aczt	629	22	unique	unique	JJ
cord-023417-by18aczt	629	23	protease	protease	NN
cord-023417-by18aczt	629	24	domains	domain	NNS
cord-023417-by18aczt	629	25	(	(	-LRB-
cord-023417-by18aczt	629	26	B	b	NN
cord-023417-by18aczt	629	27	-	-	HYPH
cord-023417-by18aczt	629	28	chains	chain	NNS
cord-023417-by18aczt	629	29	)	)	-RRB-
cord-023417-by18aczt	629	30	.	.	.
cord-023417-by18aczt	630	1	Before	before	IN
cord-023417-by18aczt	630	2	the	the	DT
cord-023417-by18aczt	630	3	identification	identification	NN
cord-023417-by18aczt	630	4	of	of	IN
cord-023417-by18aczt	630	5	MASP-3	MASP-3	NNP
cord-023417-by18aczt	630	6	,	,	,
cord-023417-by18aczt	630	7	an	an	DT
cord-023417-by18aczt	630	8	assay	assay	NN
cord-023417-by18aczt	630	9	for	for	IN
cord-023417-by18aczt	630	10	MASP	MASP	NNP
cord-023417-by18aczt	630	11	was	be	VBD
cord-023417-by18aczt	630	12	presented	present	VBN
cord-023417-by18aczt	630	13	,	,	,
cord-023417-by18aczt	630	14	based	base	VBN
cord-023417-by18aczt	630	15	on	on	IN
cord-023417-by18aczt	630	16	antibodies	antibody	NNS
cord-023417-by18aczt	630	17	against	against	IN
cord-023417-by18aczt	630	18	the	the	DT
cord-023417-by18aczt	630	19	A	A	NNP
cord-023417-by18aczt	630	20	-	-	HYPH
cord-023417-by18aczt	630	21	chain	chain	NN
cord-023417-by18aczt	630	22	of	of	IN
cord-023417-by18aczt	630	23	MASP-1	MASP-1	NNP
cord-023417-by18aczt	630	24	.	.	.
cord-023417-by18aczt	631	1	With	with	IN
cord-023417-by18aczt	631	2	the	the	DT
cord-023417-by18aczt	631	3	new	new	JJ
cord-023417-by18aczt	631	4	knowledge	knowledge	NN
cord-023417-by18aczt	631	5	of	of	IN
cord-023417-by18aczt	631	6	the	the	DT
cord-023417-by18aczt	631	7	three	three	CD
cord-023417-by18aczt	631	8	MASPs	masp	NNS
cord-023417-by18aczt	631	9	,	,	,
cord-023417-by18aczt	631	10	and	and	CC
cord-023417-by18aczt	631	11	the	the	DT
cord-023417-by18aczt	631	12	sharing	sharing	NN
cord-023417-by18aczt	631	13	of	of	IN
cord-023417-by18aczt	631	14	domains	domain	NNS
cord-023417-by18aczt	631	15	by	by	IN
cord-023417-by18aczt	631	16	MASP-1	MASP-1	NNP
cord-023417-by18aczt	631	17	and	and	CC
cord-023417-by18aczt	631	18	MASP-3	MASP-3	NNP
cord-023417-by18aczt	631	19	,	,	,
cord-023417-by18aczt	631	20	assays	assay	NNS
cord-023417-by18aczt	631	21	specific	specific	JJ
cord-023417-by18aczt	631	22	for	for	IN
cord-023417-by18aczt	631	23	the	the	DT
cord-023417-by18aczt	631	24	protease	protease	NN
cord-023417-by18aczt	631	25	domains	domain	NNS
cord-023417-by18aczt	631	26	have	have	VBP
cord-023417-by18aczt	631	27	to	to	TO
cord-023417-by18aczt	631	28	be	be	VB
cord-023417-by18aczt	631	29	constructed	construct	VBN
cord-023417-by18aczt	631	30	,	,	,
cord-023417-by18aczt	631	31	if	if	IN
cord-023417-by18aczt	631	32	one	one	PRP
cord-023417-by18aczt	631	33	wishes	wish	VBZ
cord-023417-by18aczt	631	34	to	to	TO
cord-023417-by18aczt	631	35	measure	measure	VB
cord-023417-by18aczt	631	36	the	the	DT
cord-023417-by18aczt	631	37	proteins	protein	NNS
cord-023417-by18aczt	631	38	individually	individually	RB
cord-023417-by18aczt	631	39	.	.	.
cord-023417-by18aczt	632	1	We	-PRON-	PRP
cord-023417-by18aczt	632	2	present	present	VBP
cord-023417-by18aczt	632	3	an	an	DT
cord-023417-by18aczt	632	4	assay	assay	NN
cord-023417-by18aczt	632	5	for	for	IN
cord-023417-by18aczt	632	6	quantifying	quantify	VBG
cord-023417-by18aczt	632	7	total	total	JJ
cord-023417-by18aczt	632	8	MASP-3	masp-3	NN
cord-023417-by18aczt	632	9	in	in	IN
cord-023417-by18aczt	632	10	plasma	plasma	NN
cord-023417-by18aczt	632	11	and	and	CC
cord-023417-by18aczt	632	12	serum	serum	NN
cord-023417-by18aczt	632	13	samples	sample	NNS
cord-023417-by18aczt	632	14	.	.	.
cord-023417-by18aczt	633	1	The	the	DT
cord-023417-by18aczt	633	2	assay	assay	NN
cord-023417-by18aczt	633	3	is	be	VBZ
cord-023417-by18aczt	633	4	a	a	DT
cord-023417-by18aczt	633	5	sandwich	sandwich	NN
cord-023417-by18aczt	633	6	-	-	HYPH
cord-023417-by18aczt	633	7	type	type	NN
cord-023417-by18aczt	633	8	assay	assay	NN
cord-023417-by18aczt	633	9	using	use	VBG
cord-023417-by18aczt	633	10	as	as	IN
cord-023417-by18aczt	633	11	catching	catch	VBG
cord-023417-by18aczt	633	12	antibody	antibody	NN
cord-023417-by18aczt	633	13	a	a	DT
cord-023417-by18aczt	633	14	monoclonal	monoclonal	JJ
cord-023417-by18aczt	633	15	antibody	antibody	NN
cord-023417-by18aczt	633	16	against	against	IN
cord-023417-by18aczt	633	17	the	the	DT
cord-023417-by18aczt	633	18	common	common	JJ
cord-023417-by18aczt	633	19	A	a	NN
cord-023417-by18aczt	633	20	-	-	HYPH
cord-023417-by18aczt	633	21	chain	chain	NN
cord-023417-by18aczt	633	22	of	of	IN
cord-023417-by18aczt	633	23	MASP-1/3	MASP-1/3	NNP
cord-023417-by18aczt	633	24	and	and	CC
cord-023417-by18aczt	633	25	a	a	DT
cord-023417-by18aczt	633	26	developing	develop	VBG
cord-023417-by18aczt	633	27	secondary	secondary	JJ
cord-023417-by18aczt	633	28	antibody	antibody	NN
cord-023417-by18aczt	633	29	against	against	IN
cord-023417-by18aczt	633	30	the	the	DT
cord-023417-by18aczt	633	31	C	C	NNP
cord-023417-by18aczt	633	32	-	-	HYPH
cord-023417-by18aczt	633	33	terminal	terminal	NN
cord-023417-by18aczt	633	34	part	part	NN
cord-023417-by18aczt	633	35	of	of	IN
cord-023417-by18aczt	633	36	the	the	DT
cord-023417-by18aczt	633	37	protease	protease	NN
cord-023417-by18aczt	633	38	domain	domain	NN
cord-023417-by18aczt	633	39	of	of	IN
cord-023417-by18aczt	633	40	MASP-3	MASP-3	NNP
cord-023417-by18aczt	633	41	.	.	.
cord-023417-by18aczt	634	1	We	-PRON-	PRP
cord-023417-by18aczt	634	2	have	have	VBP
cord-023417-by18aczt	634	3	used	use	VBN
cord-023417-by18aczt	634	4	this	this	DT
cord-023417-by18aczt	634	5	assay	assay	NN
cord-023417-by18aczt	634	6	for	for	IN
cord-023417-by18aczt	634	7	estimating	estimate	VBG
cord-023417-by18aczt	634	8	the	the	DT
cord-023417-by18aczt	634	9	normal	normal	JJ
cord-023417-by18aczt	634	10	concentration	concentration	NN
cord-023417-by18aczt	634	11	of	of	IN
cord-023417-by18aczt	634	12	the	the	DT
cord-023417-by18aczt	634	13	protein	protein	NN
cord-023417-by18aczt	634	14	as	as	RB
cord-023417-by18aczt	634	15	well	well	RB
cord-023417-by18aczt	634	16	as	as	IN
cord-023417-by18aczt	634	17	the	the	DT
cord-023417-by18aczt	634	18	concentration	concentration	NN
cord-023417-by18aczt	634	19	in	in	IN
cord-023417-by18aczt	634	20	patients	patient	NNS
cord-023417-by18aczt	634	21	and	and	CC
cord-023417-by18aczt	634	22	also	also	RB
cord-023417-by18aczt	634	23	for	for	IN
cord-023417-by18aczt	634	24	characterizing	characterize	VBG
cord-023417-by18aczt	634	25	by	by	IN
cord-023417-by18aczt	634	26	gel	gel	NN
cord-023417-by18aczt	634	27	permeation	permeation	NN
cord-023417-by18aczt	634	28	chromatography	chromatography	NN
cord-023417-by18aczt	634	29	the	the	DT
cord-023417-by18aczt	634	30	MASP-3	MASP-3	NNP
cord-023417-by18aczt	634	31	protein	protein	NN
cord-023417-by18aczt	634	32	in	in	IN
cord-023417-by18aczt	634	33	serum	serum	NN
cord-023417-by18aczt	634	34	.	.	.
cord-023417-by18aczt	635	1	Inducible	inducible	JJ
cord-023417-by18aczt	635	2	costimulator	costimulator	NN
cord-023417-by18aczt	635	3	ligand	ligand	NN
cord-023417-by18aczt	635	4	(	(	-LRB-
cord-023417-by18aczt	635	5	ICOSL	ICOSL	NNP
cord-023417-by18aczt	635	6	)	)	-RRB-
cord-023417-by18aczt	635	7	is	be	VBZ
cord-023417-by18aczt	635	8	a	a	DT
cord-023417-by18aczt	635	9	costimulatory	costimulatory	NN
cord-023417-by18aczt	635	10	molecule	molecule	NN
cord-023417-by18aczt	635	11	related	relate	VBN
cord-023417-by18aczt	635	12	to	to	IN
cord-023417-by18aczt	635	13	B7.1	B7.1	NNP
cord-023417-by18aczt	635	14	(	(	-LRB-
cord-023417-by18aczt	635	15	CD80	CD80	NNP
cord-023417-by18aczt	635	16	)	)	-RRB-
cord-023417-by18aczt	635	17	and	and	CC
cord-023417-by18aczt	635	18	B7.2	B7.2	NNP
cord-023417-by18aczt	635	19	(	(	-LRB-
cord-023417-by18aczt	635	20	CD86	CD86	NNP
cord-023417-by18aczt	635	21	)	)	-RRB-
cord-023417-by18aczt	635	22	.	.	.
cord-023417-by18aczt	636	1	B	b	NN
cord-023417-by18aczt	636	2	cells	cell	NNS
cord-023417-by18aczt	636	3	,	,	,
cord-023417-by18aczt	636	4	monocytes	monocyte	NNS
cord-023417-by18aczt	636	5	,	,	,
cord-023417-by18aczt	636	6	dendritic	dendritic	JJ
cord-023417-by18aczt	636	7	cells	cell	NNS
cord-023417-by18aczt	636	8	and	and	CC
cord-023417-by18aczt	636	9	endothelial	endothelial	JJ
cord-023417-by18aczt	636	10	cells	cell	NNS
cord-023417-by18aczt	636	11	express	express	VBP
cord-023417-by18aczt	636	12	ICOSL	ICOSL	NNP
cord-023417-by18aczt	636	13	.	.	.
cord-023417-by18aczt	637	1	Inducible	inducible	JJ
cord-023417-by18aczt	637	2	costimulator	costimulator	NN
cord-023417-by18aczt	637	3	(	(	-LRB-
cord-023417-by18aczt	637	4	ICOS	ICOS	NNP
cord-023417-by18aczt	637	5	)	)	-RRB-
cord-023417-by18aczt	637	6	interacts	interact	VBZ
cord-023417-by18aczt	637	7	with	with	IN
cord-023417-by18aczt	637	8	ICOSL	ICOSL	NNP
cord-023417-by18aczt	637	9	,	,	,
cord-023417-by18aczt	637	10	and	and	CC
cord-023417-by18aczt	637	11	this	this	DT
cord-023417-by18aczt	637	12	interaction	interaction	NN
cord-023417-by18aczt	637	13	leads	lead	VBZ
cord-023417-by18aczt	637	14	to	to	IN
cord-023417-by18aczt	637	15	signals	signal	NNS
cord-023417-by18aczt	637	16	involved	involve	VBN
cord-023417-by18aczt	637	17	in	in	IN
cord-023417-by18aczt	637	18	isotype	isotype	NN
cord-023417-by18aczt	637	19	switching	switch	VBG
cord-023417-by18aczt	637	20	and	and	CC
cord-023417-by18aczt	637	21	the	the	DT
cord-023417-by18aczt	637	22	development	development	NN
cord-023417-by18aczt	637	23	of	of	IN
cord-023417-by18aczt	637	24	immunological	immunological	JJ
cord-023417-by18aczt	637	25	memory	memory	NN
cord-023417-by18aczt	637	26	.	.	.
cord-023417-by18aczt	638	1	Hitherto	Hitherto	VBN
cord-023417-by18aczt	638	2	,	,	,
cord-023417-by18aczt	638	3	no	no	DT
cord-023417-by18aczt	638	4	polymorphisms	polymorphism	NNS
cord-023417-by18aczt	638	5	of	of	IN
cord-023417-by18aczt	638	6	this	this	DT
cord-023417-by18aczt	638	7	gene	gene	NN
cord-023417-by18aczt	638	8	have	have	VBP
cord-023417-by18aczt	638	9	been	be	VBN
cord-023417-by18aczt	638	10	described	describe	VBN
cord-023417-by18aczt	638	11	.	.	.
cord-023417-by18aczt	639	1	The	the	DT
cord-023417-by18aczt	639	2	aim	aim	NN
cord-023417-by18aczt	639	3	of	of	IN
cord-023417-by18aczt	639	4	this	this	DT
cord-023417-by18aczt	639	5	study	study	NN
cord-023417-by18aczt	639	6	was	be	VBD
cord-023417-by18aczt	639	7	to	to	TO
cord-023417-by18aczt	639	8	reveal	reveal	VB
cord-023417-by18aczt	639	9	variation	variation	NN
cord-023417-by18aczt	639	10	of	of	IN
cord-023417-by18aczt	639	11	the	the	DT
cord-023417-by18aczt	639	12	ICOSL	ICOSL	NNP
cord-023417-by18aczt	639	13	gene	gene	NN
cord-023417-by18aczt	639	14	in	in	IN
cord-023417-by18aczt	639	15	normal	normal	JJ
cord-023417-by18aczt	639	16	individuals	individual	NNS
cord-023417-by18aczt	639	17	.	.	.
cord-023417-by18aczt	640	1	All	all	DT
cord-023417-by18aczt	640	2	eight	eight	CD
cord-023417-by18aczt	640	3	exons	exon	NNS
cord-023417-by18aczt	640	4	,	,	,
cord-023417-by18aczt	640	5	except	except	IN
cord-023417-by18aczt	640	6	exon	exon	NN
cord-023417-by18aczt	640	7	1	1	CD
cord-023417-by18aczt	640	8	,	,	,
cord-023417-by18aczt	640	9	were	be	VBD
cord-023417-by18aczt	640	10	sequenced	sequence	VBN
cord-023417-by18aczt	640	11	with	with	IN
cord-023417-by18aczt	640	12	flanking	flank	VBG
cord-023417-by18aczt	640	13	introns	intron	NNS
cord-023417-by18aczt	640	14	in	in	IN
cord-023417-by18aczt	640	15	10	10	CD
cord-023417-by18aczt	640	16	healthy	healthy	JJ
cord-023417-by18aczt	640	17	blood	blood	NN
cord-023417-by18aczt	640	18	donors	donor	NNS
cord-023417-by18aczt	640	19	.	.	.
cord-023417-by18aczt	641	1	Eight	eight	CD
cord-023417-by18aczt	641	2	single	single	JJ
cord-023417-by18aczt	641	3	nucleotide	nucleotide	JJ
cord-023417-by18aczt	641	4	polymorphisms	polymorphism	NNS
cord-023417-by18aczt	641	5	(	(	-LRB-
cord-023417-by18aczt	641	6	SNPs	SNPs	NNP
cord-023417-by18aczt	641	7	)	)	-RRB-
cord-023417-by18aczt	641	8	and	and	CC
cord-023417-by18aczt	641	9	two	two	CD
cord-023417-by18aczt	641	10	length	length	NN
cord-023417-by18aczt	641	11	polymorphisms	polymorphism	NNS
cord-023417-by18aczt	641	12	were	be	VBD
cord-023417-by18aczt	641	13	found	find	VBN
cord-023417-by18aczt	641	14	.	.	.
cord-023417-by18aczt	642	1	One	one	CD
cord-023417-by18aczt	642	2	of	of	IN
cord-023417-by18aczt	642	3	the	the	DT
cord-023417-by18aczt	642	4	SNPs	snp	NNS
cord-023417-by18aczt	642	5	was	be	VBD
cord-023417-by18aczt	642	6	found	find	VBN
cord-023417-by18aczt	642	7	in	in	IN
cord-023417-by18aczt	642	8	the	the	DT
cord-023417-by18aczt	642	9	coding	code	VBG
cord-023417-by18aczt	642	10	regions	region	NNS
cord-023417-by18aczt	642	11	of	of	IN
cord-023417-by18aczt	642	12	the	the	DT
cord-023417-by18aczt	642	13	gene	gene	NN
cord-023417-by18aczt	642	14	.	.	.
cord-023417-by18aczt	643	1	The	the	DT
cord-023417-by18aczt	643	2	base	base	NN
cord-023417-by18aczt	643	3	involved	involve	VBN
cord-023417-by18aczt	643	4	was	be	VBD
cord-023417-by18aczt	643	5	located	locate	VBN
cord-023417-by18aczt	643	6	in	in	IN
cord-023417-by18aczt	643	7	exon	exon	NN
cord-023417-by18aczt	643	8	3	3	CD
cord-023417-by18aczt	643	9	and	and	CC
cord-023417-by18aczt	643	10	caused	cause	VBD
cord-023417-by18aczt	643	11	a	a	DT
cord-023417-by18aczt	643	12	conservative	conservative	JJ
cord-023417-by18aczt	643	13	amino	amino	NN
cord-023417-by18aczt	643	14	acid	acid	NN
cord-023417-by18aczt	643	15	change	change	NN
cord-023417-by18aczt	643	16	from	from	IN
cord-023417-by18aczt	643	17	valine	valine	NN
cord-023417-by18aczt	643	18	(	(	-LRB-
cord-023417-by18aczt	643	19	GTT	GTT	NNP
cord-023417-by18aczt	643	20	)	)	-RRB-
cord-023417-by18aczt	643	21	to	to	IN
cord-023417-by18aczt	643	22	isoleucine	isoleucine	NNP
cord-023417-by18aczt	643	23	(	(	-LRB-
cord-023417-by18aczt	643	24	ATT	ATT	NNP
cord-023417-by18aczt	643	25	)	)	-RRB-
cord-023417-by18aczt	643	26	.	.	.
cord-023417-by18aczt	644	1	Three	three	CD
cord-023417-by18aczt	644	2	individuals	individual	NNS
cord-023417-by18aczt	644	3	were	be	VBD
cord-023417-by18aczt	644	4	heterozygous	heterozygous	JJ
cord-023417-by18aczt	644	5	G	G	NNP
cord-023417-by18aczt	644	6	/	/	SYM
cord-023417-by18aczt	644	7	A	a	NN
cord-023417-by18aczt	644	8	for	for	IN
cord-023417-by18aczt	644	9	the	the	DT
cord-023417-by18aczt	644	10	exon	exon	NN
cord-023417-by18aczt	644	11	polymorphism	polymorphism	NN
cord-023417-by18aczt	644	12	,	,	,
cord-023417-by18aczt	644	13	while	while	IN
cord-023417-by18aczt	644	14	the	the	DT
cord-023417-by18aczt	644	15	remaining	remain	VBG
cord-023417-by18aczt	644	16	seven	seven	CD
cord-023417-by18aczt	644	17	individuals	individual	NNS
cord-023417-by18aczt	644	18	were	be	VBD
cord-023417-by18aczt	644	19	homozygous	homozygous	JJ
cord-023417-by18aczt	644	20	for	for	IN
cord-023417-by18aczt	645	1	the	the	DT
cord-023417-by18aczt	645	2	wildtype	wildtype	JJ
cord-023417-by18aczt	645	3	G	G	NNP
cord-023417-by18aczt	645	4	/	/	SYM
cord-023417-by18aczt	645	5	G.	G.	NNP
cord-023417-by18aczt	645	6	Exon	Exon	NNP
cord-023417-by18aczt	645	7	3	3	CD
cord-023417-by18aczt	645	8	encodes	encode	VBZ
cord-023417-by18aczt	645	9	the	the	DT
cord-023417-by18aczt	645	10	immunoglobulin	immunoglobulin	NN
cord-023417-by18aczt	645	11	variable	variable	NN
cord-023417-by18aczt	645	12	(	(	-LRB-
cord-023417-by18aczt	645	13	IgV)-like	IgV)-like	NNP
cord-023417-by18aczt	645	14	domain	domain	NN
cord-023417-by18aczt	645	15	of	of	IN
cord-023417-by18aczt	645	16	the	the	DT
cord-023417-by18aczt	645	17	molecule	molecule	NN
cord-023417-by18aczt	645	18	which	which	WDT
cord-023417-by18aczt	645	19	is	be	VBZ
cord-023417-by18aczt	645	20	situated	situate	VBN
cord-023417-by18aczt	645	21	outside	outside	IN
cord-023417-by18aczt	645	22	the	the	DT
cord-023417-by18aczt	645	23	cell	cell	NN
cord-023417-by18aczt	645	24	.	.	.
cord-023417-by18aczt	646	1	This	this	DT
cord-023417-by18aczt	646	2	means	mean	VBZ
cord-023417-by18aczt	646	3	that	that	IN
cord-023417-by18aczt	646	4	the	the	DT
cord-023417-by18aczt	646	5	amino	amino	NN
cord-023417-by18aczt	646	6	acid	acid	NN
cord-023417-by18aczt	646	7	could	could	MD
cord-023417-by18aczt	646	8	be	be	VB
cord-023417-by18aczt	646	9	critical	critical	JJ
cord-023417-by18aczt	646	10	for	for	IN
cord-023417-by18aczt	646	11	the	the	DT
cord-023417-by18aczt	646	12	stability	stability	NN
cord-023417-by18aczt	646	13	of	of	IN
cord-023417-by18aczt	646	14	the	the	DT
cord-023417-by18aczt	646	15	molecule	molecule	NN
cord-023417-by18aczt	646	16	or	or	CC
cord-023417-by18aczt	646	17	could	could	MD
cord-023417-by18aczt	646	18	constitute	constitute	VB
cord-023417-by18aczt	646	19	part	part	NN
cord-023417-by18aczt	646	20	of	of	IN
cord-023417-by18aczt	646	21	the	the	DT
cord-023417-by18aczt	646	22	binding	binding	NN
cord-023417-by18aczt	646	23	site	site	NN
cord-023417-by18aczt	646	24	for	for	IN
cord-023417-by18aczt	646	25	ICOS	ICOS	NNP
cord-023417-by18aczt	646	26	.	.	.
cord-023417-by18aczt	647	1	The	the	DT
cord-023417-by18aczt	647	2	results	result	NNS
cord-023417-by18aczt	647	3	form	form	VBP
cord-023417-by18aczt	647	4	the	the	DT
cord-023417-by18aczt	647	5	basis	basis	NN
cord-023417-by18aczt	647	6	for	for	IN
cord-023417-by18aczt	647	7	further	further	JJ
cord-023417-by18aczt	647	8	experiments	experiment	NNS
cord-023417-by18aczt	647	9	to	to	TO
cord-023417-by18aczt	647	10	find	find	VB
cord-023417-by18aczt	647	11	possible	possible	JJ
cord-023417-by18aczt	647	12	associations	association	NNS
cord-023417-by18aczt	647	13	of	of	IN
cord-023417-by18aczt	647	14	the	the	DT
cord-023417-by18aczt	647	15	alleles	allele	NNS
cord-023417-by18aczt	647	16	to	to	IN
cord-023417-by18aczt	647	17	diseases	disease	NNS
cord-023417-by18aczt	647	18	caused	cause	VBN
cord-023417-by18aczt	647	19	by	by	IN
cord-023417-by18aczt	647	20	immune	immune	JJ
cord-023417-by18aczt	647	21	dysregulation	dysregulation	NN
cord-023417-by18aczt	647	22	.	.	.
cord-023417-by18aczt	648	1	Especially	especially	RB
cord-023417-by18aczt	648	2	,	,	,
cord-023417-by18aczt	648	3	the	the	DT
cord-023417-by18aczt	648	4	exon	exon	NN
cord-023417-by18aczt	648	5	3	3	CD
cord-023417-by18aczt	648	6	variant	variant	NN
cord-023417-by18aczt	648	7	is	be	VBZ
cord-023417-by18aczt	648	8	interesting	interesting	JJ
cord-023417-by18aczt	648	9	and	and	CC
cord-023417-by18aczt	648	10	could	could	MD
cord-023417-by18aczt	648	11	play	play	VB
cord-023417-by18aczt	648	12	a	a	DT
cord-023417-by18aczt	648	13	role	role	NN
cord-023417-by18aczt	648	14	for	for	IN
cord-023417-by18aczt	648	15	the	the	DT
cord-023417-by18aczt	648	16	development	development	NN
cord-023417-by18aczt	648	17	of	of	IN
cord-023417-by18aczt	648	18	immunological	immunological	JJ
cord-023417-by18aczt	648	19	diseases	disease	NNS
cord-023417-by18aczt	648	20	.	.	.
cord-023417-by18aczt	649	1	Besides	besides	RB
cord-023417-by18aczt	649	2	,	,	,
cord-023417-by18aczt	649	3	it	-PRON-	PRP
cord-023417-by18aczt	649	4	would	would	MD
cord-023417-by18aczt	649	5	be	be	VB
cord-023417-by18aczt	649	6	interesting	interesting	JJ
cord-023417-by18aczt	649	7	to	to	TO
cord-023417-by18aczt	649	8	see	see	VB
cord-023417-by18aczt	649	9	whether	whether	IN
cord-023417-by18aczt	649	10	both	both	DT
cord-023417-by18aczt	649	11	exon	exon	NN
cord-023417-by18aczt	649	12	3	3	CD
cord-023417-by18aczt	649	13	alleles	allele	NNS
cord-023417-by18aczt	649	14	are	be	VBP
cord-023417-by18aczt	649	15	expressed	express	VBN
cord-023417-by18aczt	649	16	or	or	CC
cord-023417-by18aczt	649	17	only	only	RB
cord-023417-by18aczt	649	18	the	the	DT
cord-023417-by18aczt	649	19	wildtype	wildtype	JJ
cord-023417-by18aczt	649	20	allele	allele	NN
cord-023417-by18aczt	649	21	is	be	VBZ
cord-023417-by18aczt	649	22	functional	functional	JJ
cord-023417-by18aczt	649	23	.	.	.
cord-023417-by18aczt	650	1	Interferon	interferon	NN
cord-023417-by18aczt	650	2	-	-	HYPH
cord-023417-by18aczt	650	3	a	a	NN
cord-023417-by18aczt	650	4	/	/	SYM
cord-023417-by18aczt	650	5	b	b	NN
cord-023417-by18aczt	650	6	(	(	-LRB-
cord-023417-by18aczt	650	7	IFN	IFN	NNP
cord-023417-by18aczt	650	8	-	-	HYPH
cord-023417-by18aczt	650	9	a	a	NNP
cord-023417-by18aczt	650	10	/	/	SYM
cord-023417-by18aczt	650	11	b	b	NN
cord-023417-by18aczt	650	12	)	)	-RRB-
cord-023417-by18aczt	650	13	is	be	VBZ
cord-023417-by18aczt	650	14	increasingly	increasingly	RB
cord-023417-by18aczt	650	15	used	use	VBN
cord-023417-by18aczt	650	16	as	as	IN
cord-023417-by18aczt	650	17	antiviral	antiviral	JJ
cord-023417-by18aczt	650	18	and	and	CC
cord-023417-by18aczt	650	19	immunomodulatory	immunomodulatory	JJ
cord-023417-by18aczt	650	20	therapies	therapy	NNS
cord-023417-by18aczt	650	21	.	.	.
cord-023417-by18aczt	651	1	Unfortunately	unfortunately	RB
cord-023417-by18aczt	651	2	,	,	,
cord-023417-by18aczt	651	3	bioavailability	bioavailability	NN
cord-023417-by18aczt	651	4	varies	vary	VBZ
cord-023417-by18aczt	651	5	with	with	IN
cord-023417-by18aczt	651	6	IFN	IFN	NNP
cord-023417-by18aczt	651	7	species	specie	NNS
cord-023417-by18aczt	651	8	and	and	CC
cord-023417-by18aczt	651	9	mode	mode	NN
cord-023417-by18aczt	651	10	of	of	IN
cord-023417-by18aczt	651	11	administration	administration	NN
cord-023417-by18aczt	651	12	,	,	,
cord-023417-by18aczt	651	13	and	and	CC
cord-023417-by18aczt	651	14	all	all	DT
cord-023417-by18aczt	651	15	IFN	IFN	NNP
cord-023417-by18aczt	651	16	species	specie	NNS
cord-023417-by18aczt	651	17	are	be	VBP
cord-023417-by18aczt	651	18	potentially	potentially	RB
cord-023417-by18aczt	651	19	immunogenic	immunogenic	JJ
cord-023417-by18aczt	651	20	.	.	.
cord-023417-by18aczt	652	1	Assays	assay	NNS
cord-023417-by18aczt	652	2	for	for	IN
cord-023417-by18aczt	652	3	antiviral	antiviral	JJ
cord-023417-by18aczt	652	4	activity	activity	NN
cord-023417-by18aczt	652	5	(	(	-LRB-
cord-023417-by18aczt	652	6	IFN	IFN	NNP
cord-023417-by18aczt	652	7	)	)	-RRB-
cord-023417-by18aczt	652	8	and	and	CC
cord-023417-by18aczt	652	9	antiviral	antiviral	JJ
cord-023417-by18aczt	652	10	neutralization	neutralization	NN
cord-023417-by18aczt	652	11	(	(	-LRB-
cord-023417-by18aczt	652	12	antibodies	antibody	NNS
cord-023417-by18aczt	652	13	,	,	,
cord-023417-by18aczt	652	14	NAb	NAb	NNS
cord-023417-by18aczt	652	15	)	)	-RRB-
cord-023417-by18aczt	652	16	have	have	VBP
cord-023417-by18aczt	652	17	been	be	VBN
cord-023417-by18aczt	652	18	used	use	VBN
cord-023417-by18aczt	652	19	for	for	IN
cord-023417-by18aczt	652	20	some	some	DT
cord-023417-by18aczt	652	21	time	time	NN
cord-023417-by18aczt	652	22	to	to	TO
cord-023417-by18aczt	652	23	monitor	monitor	VB
cord-023417-by18aczt	652	24	patients	patient	NNS
cord-023417-by18aczt	652	25	on	on	IN
cord-023417-by18aczt	652	26	IFN	IFN	NNP
cord-023417-by18aczt	652	27	biologicals	biological	NNS
cord-023417-by18aczt	652	28	.	.	.
cord-023417-by18aczt	653	1	These	these	DT
cord-023417-by18aczt	653	2	assays	assay	NNS
cord-023417-by18aczt	653	3	require	require	VBP
cord-023417-by18aczt	653	4	laborious	laborious	JJ
cord-023417-by18aczt	653	5	titrations	titration	NNS
cord-023417-by18aczt	653	6	making	make	VBG
cord-023417-by18aczt	653	7	them	-PRON-	PRP
cord-023417-by18aczt	653	8	unsuitable	unsuitable	JJ
cord-023417-by18aczt	653	9	for	for	IN
cord-023417-by18aczt	653	10	large	large	JJ
cord-023417-by18aczt	653	11	-	-	HYPH
cord-023417-by18aczt	653	12	scale	scale	NN
cord-023417-by18aczt	653	13	clinical	clinical	JJ
cord-023417-by18aczt	653	14	use	use	NN
cord-023417-by18aczt	653	15	.	.	.
cord-023417-by18aczt	654	1	Myxovirus	Myxovirus	NNP
cord-023417-by18aczt	654	2	A	A	NNP
cord-023417-by18aczt	654	3	(	(	-LRB-
cord-023417-by18aczt	654	4	MxA	mxa	NN
cord-023417-by18aczt	654	5	)	)	-RRB-
cord-023417-by18aczt	654	6	is	be	VBZ
cord-023417-by18aczt	654	7	a	a	DT
cord-023417-by18aczt	654	8	resistance	resistance	NN
cord-023417-by18aczt	654	9	GTPbinding	gtpbinding	NN
cord-023417-by18aczt	654	10	protein	protein	NN
cord-023417-by18aczt	654	11	that	that	WDT
cord-023417-by18aczt	654	12	is	be	VBZ
cord-023417-by18aczt	654	13	specifically	specifically	RB
cord-023417-by18aczt	654	14	induced	induce	VBN
cord-023417-by18aczt	654	15	by	by	IN
cord-023417-by18aczt	654	16	treatment	treatment	NN
cord-023417-by18aczt	654	17	with	with	IN
cord-023417-by18aczt	654	18	type	type	NN
cord-023417-by18aczt	654	19	1	1	CD
cord-023417-by18aczt	654	20	IFNs	ifn	NNS
cord-023417-by18aczt	654	21	.	.	.
cord-023417-by18aczt	655	1	For	for	IN
cord-023417-by18aczt	655	2	example	example	NN
cord-023417-by18aczt	655	3	,	,	,
cord-023417-by18aczt	655	4	IFN	IFN	NNP
cord-023417-by18aczt	655	5	-	-	HYPH
cord-023417-by18aczt	655	6	b	b	NNP
cord-023417-by18aczt	655	7	-	-	HYPH
cord-023417-by18aczt	655	8	induced	induce	VBN
cord-023417-by18aczt	655	9	MxA	mxa	NN
cord-023417-by18aczt	655	10	in	in	IN
cord-023417-by18aczt	655	11	blood	blood	NN
cord-023417-by18aczt	655	12	leucocytes	leucocyte	NNS
cord-023417-by18aczt	655	13	has	have	VBZ
cord-023417-by18aczt	655	14	been	be	VBN
cord-023417-by18aczt	655	15	used	use	VBN
cord-023417-by18aczt	655	16	as	as	IN
cord-023417-by18aczt	655	17	a	a	DT
cord-023417-by18aczt	655	18	biomarker	biomarker	NN
cord-023417-by18aczt	655	19	in	in	IN
cord-023417-by18aczt	655	20	IFN	IFN	NNP
cord-023417-by18aczt	655	21	-	-	HYPH
cord-023417-by18aczt	655	22	btreated	btreate	VBN
cord-023417-by18aczt	655	23	patients	patient	NNS
cord-023417-by18aczt	655	24	with	with	IN
cord-023417-by18aczt	655	25	multiple	multiple	JJ
cord-023417-by18aczt	655	26	sclerosis	sclerosis	NN
cord-023417-by18aczt	655	27	.	.	.
cord-023417-by18aczt	656	1	However	however	RB
cord-023417-by18aczt	656	2	,	,	,
cord-023417-by18aczt	656	3	the	the	DT
cord-023417-by18aczt	656	4	degree	degree	NN
cord-023417-by18aczt	656	5	of	of	IN
cord-023417-by18aczt	656	6	specificity	specificity	NN
cord-023417-by18aczt	656	7	of	of	IN
cord-023417-by18aczt	656	8	MxA	mxa	NN
cord-023417-by18aczt	656	9	in	in	IN
cord-023417-by18aczt	656	10	this	this	DT
cord-023417-by18aczt	656	11	regard	regard	NN
cord-023417-by18aczt	656	12	is	be	VBZ
cord-023417-by18aczt	656	13	unclear	unclear	JJ
cord-023417-by18aczt	656	14	,	,	,
cord-023417-by18aczt	656	15	and	and	CC
cord-023417-by18aczt	656	16	measurements	measurement	NNS
cord-023417-by18aczt	656	17	of	of	IN
cord-023417-by18aczt	656	18	MxA	mxa	NN
cord-023417-by18aczt	656	19	protein	protein	NN
cord-023417-by18aczt	656	20	and/or	and/or	CC
cord-023417-by18aczt	657	1	mRNA	mrna	NN
cord-023417-by18aczt	657	2	are	be	VBP
cord-023417-by18aczt	657	3	not	not	RB
cord-023417-by18aczt	657	4	yet	yet	RB
cord-023417-by18aczt	657	5	suitable	suitable	JJ
cord-023417-by18aczt	657	6	for	for	IN
cord-023417-by18aczt	657	7	routine	routine	JJ
cord-023417-by18aczt	657	8	clinical	clinical	JJ
cord-023417-by18aczt	657	9	use	use	NN
cord-023417-by18aczt	657	10	.	.	.
cord-023417-by18aczt	658	1	In	in	IN
cord-023417-by18aczt	658	2	an	an	DT
cord-023417-by18aczt	658	3	attempt	attempt	NN
cord-023417-by18aczt	658	4	to	to	TO
cord-023417-by18aczt	658	5	find	find	VB
cord-023417-by18aczt	658	6	new	new	JJ
cord-023417-by18aczt	658	7	and	and	CC
cord-023417-by18aczt	658	8	better	well	JJR
cord-023417-by18aczt	658	9	reporter	reporter	NN
cord-023417-by18aczt	658	10	genes	gene	NNS
cord-023417-by18aczt	658	11	(	(	-LRB-
cord-023417-by18aczt	658	12	and	and	CC
cord-023417-by18aczt	658	13	,	,	,
cord-023417-by18aczt	658	14	hopefully	hopefully	RB
cord-023417-by18aczt	658	15	,	,	,
cord-023417-by18aczt	658	16	genes	gene	NNS
cord-023417-by18aczt	658	17	and	and	CC
cord-023417-by18aczt	658	18	gene	gene	NN
cord-023417-by18aczt	658	19	products	product	NNS
cord-023417-by18aczt	658	20	with	with	IN
cord-023417-by18aczt	658	21	proven	prove	VBN
cord-023417-by18aczt	658	22	specificity	specificity	NN
cord-023417-by18aczt	658	23	for	for	IN
cord-023417-by18aczt	658	24	IFN	IFN	NNP
cord-023417-by18aczt	658	25	-	-	:
cord-023417-by18aczt	658	26	a	a	NN
cord-023417-by18aczt	658	27	and	and	CC
cord-023417-by18aczt	658	28	-b	-b	SYM
cord-023417-by18aczt	658	29	)	)	-RRB-
cord-023417-by18aczt	658	30	,	,	,
cord-023417-by18aczt	658	31	microarray	microarray	NN
cord-023417-by18aczt	658	32	screenings	screening	NNS
cord-023417-by18aczt	658	33	with	with	IN
cord-023417-by18aczt	658	34	U133A	U133A	NNP
cord-023417-by18aczt	658	35	GeneChips	GeneChips	NNP
cord-023417-by18aczt	658	36	(	(	-LRB-
cord-023417-by18aczt	658	37	Affymetrix	Affymetrix	NNP
cord-023417-by18aczt	658	38	)	)	-RRB-
cord-023417-by18aczt	658	39	were	be	VBD
cord-023417-by18aczt	658	40	carried	carry	VBN
cord-023417-by18aczt	658	41	using	use	VBG
cord-023417-by18aczt	658	42	human	human	JJ
cord-023417-by18aczt	658	43	blood	blood	NN
cord-023417-by18aczt	658	44	leucocytes	leucocyte	NNS
cord-023417-by18aczt	658	45	and	and	CC
cord-023417-by18aczt	658	46	the	the	DT
cord-023417-by18aczt	658	47	human	human	JJ
cord-023417-by18aczt	658	48	lung	lung	NN
cord-023417-by18aczt	658	49	carcinoma	carcinoma	NN
cord-023417-by18aczt	658	50	cell	cell	NN
cord-023417-by18aczt	658	51	line	line	NN
cord-023417-by18aczt	658	52	A549	a549	JJ
cord-023417-by18aczt	658	53	.	.	.
cord-023417-by18aczt	659	1	We	-PRON-	PRP
cord-023417-by18aczt	659	2	studied	study	VBD
cord-023417-by18aczt	659	3	the	the	DT
cord-023417-by18aczt	659	4	simultaneous	simultaneous	JJ
cord-023417-by18aczt	659	5	expression	expression	NN
cord-023417-by18aczt	659	6	of	of	IN
cord-023417-by18aczt	659	7	22,000	22,000	CD
cord-023417-by18aczt	659	8	transcripts	transcript	NNS
cord-023417-by18aczt	659	9	before	before	IN
cord-023417-by18aczt	659	10	and	and	CC
cord-023417-by18aczt	659	11	after	after	IN
cord-023417-by18aczt	659	12	exposure	exposure	NN
cord-023417-by18aczt	659	13	to	to	IN
cord-023417-by18aczt	659	14	human	human	JJ
cord-023417-by18aczt	659	15	recombinant	recombinant	JJ
cord-023417-by18aczt	659	16	IFN	IFN	NNP
cord-023417-by18aczt	659	17	-	-	HYPH
cord-023417-by18aczt	659	18	a	a	NNP
cord-023417-by18aczt	659	19	and	and	CC
cord-023417-by18aczt	659	20	IFN	IFN	NNP
cord-023417-by18aczt	659	21	-	-	HYPH
cord-023417-by18aczt	659	22	b	b	NNP
cord-023417-by18aczt	659	23	and	and	CC
cord-023417-by18aczt	659	24	other	other	JJ
cord-023417-by18aczt	659	25	antiviral	antiviral	JJ
cord-023417-by18aczt	659	26	and	and	CC
cord-023417-by18aczt	659	27	immunomodulatory	immunomodulatory	JJ
cord-023417-by18aczt	659	28	cytokines	cytokine	NNS
cord-023417-by18aczt	659	29	.	.	.
cord-023417-by18aczt	660	1	The	the	DT
cord-023417-by18aczt	660	2	results	result	NNS
cord-023417-by18aczt	660	3	will	will	MD
cord-023417-by18aczt	660	4	be	be	VB
cord-023417-by18aczt	660	5	presented	present	VBN
cord-023417-by18aczt	660	6	at	at	IN
cord-023417-by18aczt	660	7	the	the	DT
cord-023417-by18aczt	660	8	conference	conference	NN
cord-023417-by18aczt	660	9	.	.	.
cord-023417-by18aczt	661	1	Interferon	interferon	NN
cord-023417-by18aczt	661	2	-	-	HYPH
cord-023417-by18aczt	661	3	a	a	NN
cord-023417-by18aczt	661	4	/	/	SYM
cord-023417-by18aczt	661	5	b	b	NN
cord-023417-by18aczt	661	6	(	(	-LRB-
cord-023417-by18aczt	661	7	IFN	IFN	NNP
cord-023417-by18aczt	661	8	-	-	HYPH
cord-023417-by18aczt	661	9	a	a	NNP
cord-023417-by18aczt	661	10	/	/	SYM
cord-023417-by18aczt	661	11	b	b	NN
cord-023417-by18aczt	661	12	)	)	-RRB-
cord-023417-by18aczt	661	13	is	be	VBZ
cord-023417-by18aczt	661	14	increasingly	increasingly	RB
cord-023417-by18aczt	661	15	used	use	VBN
cord-023417-by18aczt	661	16	as	as	IN
cord-023417-by18aczt	661	17	antiviral	antiviral	JJ
cord-023417-by18aczt	661	18	and	and	CC
cord-023417-by18aczt	661	19	immunomodulatory	immunomodulatory	JJ
cord-023417-by18aczt	661	20	therapies	therapy	NNS
cord-023417-by18aczt	661	21	.	.	.
cord-023417-by18aczt	662	1	Unfortunately	unfortunately	RB
cord-023417-by18aczt	662	2	,	,	,
cord-023417-by18aczt	662	3	bioavailability	bioavailability	NN
cord-023417-by18aczt	662	4	varies	vary	VBZ
cord-023417-by18aczt	662	5	with	with	IN
cord-023417-by18aczt	662	6	IFN	IFN	NNP
cord-023417-by18aczt	662	7	species	specie	NNS
cord-023417-by18aczt	662	8	and	and	CC
cord-023417-by18aczt	662	9	mode	mode	NN
cord-023417-by18aczt	662	10	of	of	IN
cord-023417-by18aczt	662	11	administration	administration	NN
cord-023417-by18aczt	662	12	,	,	,
cord-023417-by18aczt	662	13	and	and	CC
cord-023417-by18aczt	662	14	all	all	DT
cord-023417-by18aczt	662	15	IFN	IFN	NNP
cord-023417-by18aczt	662	16	species	specie	NNS
cord-023417-by18aczt	662	17	are	be	VBP
cord-023417-by18aczt	662	18	potentially	potentially	RB
cord-023417-by18aczt	662	19	immunogenic	immunogenic	JJ
cord-023417-by18aczt	662	20	.	.	.
cord-023417-by18aczt	663	1	Assays	assay	NNS
cord-023417-by18aczt	663	2	for	for	IN
cord-023417-by18aczt	663	3	antiviral	antiviral	JJ
cord-023417-by18aczt	663	4	activity	activity	NN
cord-023417-by18aczt	663	5	(	(	-LRB-
cord-023417-by18aczt	663	6	IFN	IFN	NNP
cord-023417-by18aczt	663	7	)	)	-RRB-
cord-023417-by18aczt	663	8	and	and	CC
cord-023417-by18aczt	663	9	antiviral	antiviral	JJ
cord-023417-by18aczt	663	10	neutralization	neutralization	NN
cord-023417-by18aczt	663	11	(	(	-LRB-
cord-023417-by18aczt	663	12	antibodies	antibody	NNS
cord-023417-by18aczt	663	13	,	,	,
cord-023417-by18aczt	663	14	NAb	NAb	NNS
cord-023417-by18aczt	663	15	)	)	-RRB-
cord-023417-by18aczt	663	16	have	have	VBP
cord-023417-by18aczt	663	17	been	be	VBN
cord-023417-by18aczt	663	18	used	use	VBN
cord-023417-by18aczt	663	19	for	for	IN
cord-023417-by18aczt	663	20	some	some	DT
cord-023417-by18aczt	663	21	time	time	NN
cord-023417-by18aczt	663	22	to	to	TO
cord-023417-by18aczt	663	23	monitor	monitor	VB
cord-023417-by18aczt	663	24	patients	patient	NNS
cord-023417-by18aczt	663	25	on	on	IN
cord-023417-by18aczt	663	26	IFN	IFN	NNP
cord-023417-by18aczt	663	27	biologicals	biological	NNS
cord-023417-by18aczt	663	28	.	.	.
cord-023417-by18aczt	664	1	These	these	DT
cord-023417-by18aczt	664	2	assays	assay	NNS
cord-023417-by18aczt	664	3	require	require	VBP
cord-023417-by18aczt	664	4	laborious	laborious	JJ
cord-023417-by18aczt	664	5	titrations	titration	NNS
cord-023417-by18aczt	664	6	making	make	VBG
cord-023417-by18aczt	664	7	them	-PRON-	PRP
cord-023417-by18aczt	664	8	unsuitable	unsuitable	JJ
cord-023417-by18aczt	664	9	for	for	IN
cord-023417-by18aczt	664	10	large	large	JJ
cord-023417-by18aczt	664	11	-	-	HYPH
cord-023417-by18aczt	664	12	scale	scale	NN
cord-023417-by18aczt	664	13	clinical	clinical	JJ
cord-023417-by18aczt	664	14	use	use	NN
cord-023417-by18aczt	664	15	.	.	.
cord-023417-by18aczt	665	1	Our	-PRON-	PRP$
cord-023417-by18aczt	665	2	laboratories	laboratory	NNS
cord-023417-by18aczt	665	3	have	have	VBP
cord-023417-by18aczt	665	4	therefore	therefore	RB
cord-023417-by18aczt	665	5	modified	modify	VBN
cord-023417-by18aczt	665	6	the	the	DT
cord-023417-by18aczt	665	7	antiviral	antiviral	JJ
cord-023417-by18aczt	665	8	assays	assay	NNS
cord-023417-by18aczt	665	9	for	for	IN
cord-023417-by18aczt	665	10	IFN	IFN	NNP
cord-023417-by18aczt	665	11	bioactivity	bioactivity	NNP
cord-023417-by18aczt	665	12	and	and	CC
cord-023417-by18aczt	665	13	Nab	Nab	NNP
cord-023417-by18aczt	665	14	,	,	,
cord-023417-by18aczt	665	15	so	so	IN
cord-023417-by18aczt	665	16	that	that	IN
cord-023417-by18aczt	665	17	they	-PRON-	PRP
cord-023417-by18aczt	665	18	are	be	VBP
cord-023417-by18aczt	665	19	suitable	suitable	JJ
cord-023417-by18aczt	665	20	for	for	IN
cord-023417-by18aczt	665	21	large	large	JJ
cord-023417-by18aczt	665	22	-	-	HYPH
cord-023417-by18aczt	665	23	scale	scale	NN
cord-023417-by18aczt	665	24	screening	screening	NN
cord-023417-by18aczt	665	25	in	in	IN
cord-023417-by18aczt	665	26	specialized	specialized	JJ
cord-023417-by18aczt	665	27	laboratories	laboratory	NNS
cord-023417-by18aczt	665	28	.	.	.
cord-023417-by18aczt	666	1	The	the	DT
cord-023417-by18aczt	666	2	read	read	NN
cord-023417-by18aczt	666	3	-	-	HYPH
cord-023417-by18aczt	666	4	out	out	NN
cord-023417-by18aczt	666	5	is	be	VBZ
cord-023417-by18aczt	666	6	survival	survival	NN
cord-023417-by18aczt	666	7	of	of	IN
cord-023417-by18aczt	666	8	a	a	DT
cord-023417-by18aczt	666	9	subcloned	subcloned	JJ
cord-023417-by18aczt	666	10	A549	a549	JJ
cord-023417-by18aczt	666	11	cell	cell	NN
cord-023417-by18aczt	666	12	line	line	NN
cord-023417-by18aczt	666	13	in	in	IN
cord-023417-by18aczt	666	14	the	the	DT
cord-023417-by18aczt	666	15	presence	presence	NN
cord-023417-by18aczt	666	16	of	of	IN
cord-023417-by18aczt	666	17	an	an	DT
cord-023417-by18aczt	666	18	otherwise	otherwise	RB
cord-023417-by18aczt	666	19	lethal	lethal	JJ
cord-023417-by18aczt	666	20	amount	amount	NN
cord-023417-by18aczt	666	21	of	of	IN
cord-023417-by18aczt	666	22	virus	virus	NN
cord-023417-by18aczt	666	23	.	.	.
cord-023417-by18aczt	667	1	Thus	thus	RB
cord-023417-by18aczt	667	2	,	,	,
cord-023417-by18aczt	667	3	survival	survival	NN
cord-023417-by18aczt	667	4	increases	increase	NNS
cord-023417-by18aczt	667	5	in	in	IN
cord-023417-by18aczt	667	6	the	the	DT
cord-023417-by18aczt	667	7	presence	presence	NN
cord-023417-by18aczt	667	8	of	of	IN
cord-023417-by18aczt	667	9	type	type	NN
cord-023417-by18aczt	667	10	1	1	CD
cord-023417-by18aczt	667	11	IFN	IFN	NNP
cord-023417-by18aczt	667	12	and	and	CC
cord-023417-by18aczt	667	13	decreases	decrease	VBZ
cord-023417-by18aczt	667	14	in	in	IN
cord-023417-by18aczt	667	15	the	the	DT
cord-023417-by18aczt	667	16	presence	presence	NN
cord-023417-by18aczt	667	17	of	of	IN
cord-023417-by18aczt	667	18	NAb	NAb	NNS
cord-023417-by18aczt	667	19	against	against	IN
cord-023417-by18aczt	667	20	the	the	DT
cord-023417-by18aczt	667	21	IFN	IFN	NNP
cord-023417-by18aczt	667	22	added	add	VBD
cord-023417-by18aczt	667	23	to	to	IN
cord-023417-by18aczt	667	24	the	the	DT
cord-023417-by18aczt	667	25	cells	cell	NNS
cord-023417-by18aczt	667	26	.	.	.
cord-023417-by18aczt	668	1	MxA	MxA	NNP
cord-023417-by18aczt	668	2	is	be	VBZ
cord-023417-by18aczt	668	3	induced	induce	VBN
cord-023417-by18aczt	668	4	by	by	IN
cord-023417-by18aczt	668	5	type	type	NN
cord-023417-by18aczt	668	6	1	1	CD
cord-023417-by18aczt	668	7	IFN	IFN	NNP
cord-023417-by18aczt	668	8	and	and	CC
cord-023417-by18aczt	668	9	can	can	MD
cord-023417-by18aczt	668	10	be	be	VB
cord-023417-by18aczt	668	11	used	use	VBN
cord-023417-by18aczt	668	12	for	for	IN
cord-023417-by18aczt	668	13	measuring	measure	VBG
cord-023417-by18aczt	668	14	the	the	DT
cord-023417-by18aczt	668	15	Nab	Nab	NNP
cord-023417-by18aczt	668	16	activity	activity	NN
cord-023417-by18aczt	668	17	.	.	.
cord-023417-by18aczt	669	1	In	in	IN
cord-023417-by18aczt	669	2	another	another	DT
cord-023417-by18aczt	669	3	assay	assay	NN
cord-023417-by18aczt	669	4	,	,	,
cord-023417-by18aczt	669	5	the	the	DT
cord-023417-by18aczt	669	6	MxA	mxa	NN
cord-023417-by18aczt	669	7	level	level	NN
cord-023417-by18aczt	669	8	in	in	IN
cord-023417-by18aczt	669	9	the	the	DT
cord-023417-by18aczt	669	10	A549	a549	JJ
cord-023417-by18aczt	669	11	cell	cell	NN
cord-023417-by18aczt	669	12	line	line	NN
cord-023417-by18aczt	669	13	is	be	VBZ
cord-023417-by18aczt	669	14	measured	measure	VBN
cord-023417-by18aczt	669	15	.	.	.
cord-023417-by18aczt	670	1	In	in	IN
cord-023417-by18aczt	670	2	an	an	DT
cord-023417-by18aczt	670	3	attempt	attempt	NN
cord-023417-by18aczt	670	4	to	to	TO
cord-023417-by18aczt	670	5	find	find	VB
cord-023417-by18aczt	670	6	a	a	DT
cord-023417-by18aczt	670	7	new	new	JJ
cord-023417-by18aczt	670	8	and	and	CC
cord-023417-by18aczt	670	9	better	well	JJR
cord-023417-by18aczt	670	10	reporter	reporter	NN
cord-023417-by18aczt	670	11	gene	gene	NN
cord-023417-by18aczt	670	12	for	for	IN
cord-023417-by18aczt	670	13	type	type	NN
cord-023417-by18aczt	670	14	1	1	CD
cord-023417-by18aczt	670	15	IFN	IFN	NNP
cord-023417-by18aczt	670	16	than	than	IN
cord-023417-by18aczt	670	17	MxA	mxa	NN
cord-023417-by18aczt	670	18	and	and	CC
cord-023417-by18aczt	670	19	genes	gene	NNS
cord-023417-by18aczt	670	20	specific	specific	JJ
cord-023417-by18aczt	670	21	for	for	IN
cord-023417-by18aczt	670	22	either	either	CC
cord-023417-by18aczt	670	23	IFN	IFN	NNP
cord-023417-by18aczt	670	24	-	-	HYPH
cord-023417-by18aczt	670	25	a	a	NN
cord-023417-by18aczt	670	26	or	or	CC
cord-023417-by18aczt	670	27	-b	-b	SYM
cord-023417-by18aczt	670	28	,	,	,
cord-023417-by18aczt	670	29	a	a	DT
cord-023417-by18aczt	670	30	micro	micro	JJ
cord-023417-by18aczt	670	31	array	array	NN
cord-023417-by18aczt	670	32	screen	screen	NN
cord-023417-by18aczt	670	33	was	be	VBD
cord-023417-by18aczt	670	34	carried	carry	VBN
cord-023417-by18aczt	670	35	using	use	VBG
cord-023417-by18aczt	670	36	the	the	DT
cord-023417-by18aczt	670	37	U133A	U133A	NNP
cord-023417-by18aczt	670	38	chip	chip	NN
cord-023417-by18aczt	670	39	from	from	IN
cord-023417-by18aczt	670	40	Affymetrix	Affymetrix	NNP
cord-023417-by18aczt	670	41	.	.	.
cord-023417-by18aczt	671	1	The	the	DT
cord-023417-by18aczt	671	2	expression	expression	NN
cord-023417-by18aczt	671	3	of	of	IN
cord-023417-by18aczt	671	4	22,000	22,000	CD
cord-023417-by18aczt	671	5	genes	gene	NNS
cord-023417-by18aczt	671	6	can	can	MD
cord-023417-by18aczt	671	7	be	be	VB
cord-023417-by18aczt	671	8	studied	study	VBN
cord-023417-by18aczt	671	9	simultaneous	simultaneous	JJ
cord-023417-by18aczt	671	10	with	with	IN
cord-023417-by18aczt	671	11	this	this	DT
cord-023417-by18aczt	671	12	technology	technology	NN
cord-023417-by18aczt	671	13	.	.	.
cord-023417-by18aczt	672	1	The	the	DT
cord-023417-by18aczt	672	2	results	result	NNS
cord-023417-by18aczt	672	3	will	will	MD
cord-023417-by18aczt	672	4	be	be	VB
cord-023417-by18aczt	672	5	presented	present	VBN
cord-023417-by18aczt	672	6	at	at	IN
cord-023417-by18aczt	672	7	the	the	DT
cord-023417-by18aczt	672	8	conference	conference	NN
cord-023417-by18aczt	672	9	.	.	.
cord-023417-by18aczt	673	1	In	in	IN
cord-023417-by18aczt	673	2	our	-PRON-	PRP$
cord-023417-by18aczt	673	3	laboratory	laboratory	NN
cord-023417-by18aczt	673	4	,	,	,
cord-023417-by18aczt	673	5	we	-PRON-	PRP
cord-023417-by18aczt	673	6	have	have	VBP
cord-023417-by18aczt	673	7	developed	develop	VBN
cord-023417-by18aczt	673	8	a	a	DT
cord-023417-by18aczt	673	9	database	database	NN
cord-023417-by18aczt	673	10	system	system	NN
cord-023417-by18aczt	673	11	,	,	,
cord-023417-by18aczt	673	12	which	which	WDT
cord-023417-by18aczt	673	13	we	-PRON-	PRP
cord-023417-by18aczt	673	14	believe	believe	VBP
cord-023417-by18aczt	673	15	is	be	VBZ
cord-023417-by18aczt	673	16	of	of	IN
cord-023417-by18aczt	673	17	immediate	immediate	JJ
cord-023417-by18aczt	673	18	interest	interest	NN
cord-023417-by18aczt	673	19	to	to	IN
cord-023417-by18aczt	673	20	the	the	DT
cord-023417-by18aczt	673	21	general	general	JJ
cord-023417-by18aczt	673	22	scientific	scientific	JJ
cord-023417-by18aczt	673	23	community	community	NN
cord-023417-by18aczt	673	24	.	.	.
cord-023417-by18aczt	674	1	The	the	DT
cord-023417-by18aczt	674	2	database	database	NN
cord-023417-by18aczt	674	3	represents	represent	VBZ
cord-023417-by18aczt	674	4	a	a	DT
cord-023417-by18aczt	674	5	computerbased	computerbased	JJ
cord-023417-by18aczt	674	6	replacement	replacement	NN
cord-023417-by18aczt	674	7	for	for	IN
cord-023417-by18aczt	674	8	the	the	DT
cord-023417-by18aczt	674	9	laboratory	laboratory	NN
cord-023417-by18aczt	674	10	notebooks	notebook	NNS
cord-023417-by18aczt	674	11	used	use	VBN
cord-023417-by18aczt	674	12	in	in	IN
cord-023417-by18aczt	674	13	the	the	DT
cord-023417-by18aczt	674	14	majority	majority	NN
cord-023417-by18aczt	674	15	of	of	IN
cord-023417-by18aczt	674	16	research	research	NN
cord-023417-by18aczt	674	17	laboratories	laboratory	NNS
cord-023417-by18aczt	674	18	worldwide	worldwide	RB
cord-023417-by18aczt	674	19	.	.	.
cord-023417-by18aczt	675	1	In	in	IN
cord-023417-by18aczt	675	2	addition	addition	NN
cord-023417-by18aczt	675	3	,	,	,
cord-023417-by18aczt	675	4	the	the	DT
cord-023417-by18aczt	675	5	database	database	NN
cord-023417-by18aczt	675	6	provides	provide	VBZ
cord-023417-by18aczt	675	7	an	an	DT
cord-023417-by18aczt	675	8	effective	effective	JJ
cord-023417-by18aczt	675	9	tool	tool	NN
cord-023417-by18aczt	675	10	for	for	IN
cord-023417-by18aczt	675	11	organizing	organize	VBG
cord-023417-by18aczt	675	12	and	and	CC
cord-023417-by18aczt	675	13	managing	manage	VBG
cord-023417-by18aczt	675	14	laboratory	laboratory	NN
cord-023417-by18aczt	675	15	information	information	NN
cord-023417-by18aczt	675	16	at	at	IN
cord-023417-by18aczt	675	17	all	all	DT
cord-023417-by18aczt	675	18	levels	level	NNS
cord-023417-by18aczt	675	19	,	,	,
cord-023417-by18aczt	675	20	spanning	span	VBG
cord-023417-by18aczt	675	21	from	from	IN
cord-023417-by18aczt	675	22	managing	manage	VBG
cord-023417-by18aczt	675	23	and	and	CC
cord-023417-by18aczt	675	24	revising	revise	VBG
cord-023417-by18aczt	675	25	standard	standard	JJ
cord-023417-by18aczt	675	26	operating	operate	VBG
cord-023417-by18aczt	675	27	procedures	procedure	NNS
cord-023417-by18aczt	675	28	and	and	CC
cord-023417-by18aczt	675	29	producing	produce	VBG
cord-023417-by18aczt	675	30	documentation	documentation	NN
cord-023417-by18aczt	675	31	of	of	IN
cord-023417-by18aczt	675	32	research	research	NN
cord-023417-by18aczt	675	33	activities	activity	NNS
cord-023417-by18aczt	675	34	to	to	IN
cord-023417-by18aczt	675	35	keeping	keep	VBG
cord-023417-by18aczt	675	36	track	track	NN
cord-023417-by18aczt	675	37	of	of	IN
cord-023417-by18aczt	675	38	data	datum	NNS
cord-023417-by18aczt	675	39	and	and	CC
cord-023417-by18aczt	675	40	conclusions	conclusion	NNS
cord-023417-by18aczt	675	41	.	.	.
cord-023417-by18aczt	676	1	Using	use	VBG
cord-023417-by18aczt	676	2	the	the	DT
cord-023417-by18aczt	676	3	commercially	commercially	RB
cord-023417-by18aczt	676	4	available	available	JJ
cord-023417-by18aczt	676	5	database	database	NN
cord-023417-by18aczt	676	6	toolkit	toolkit	NN
cord-023417-by18aczt	676	7	software	software	NN
cord-023417-by18aczt	676	8	FILEMAKER	FILEMAKER	NNP
cord-023417-by18aczt	676	9	PRO	PRO	NNP
cord-023417-by18aczt	676	10	,	,	,
cord-023417-by18aczt	676	11	we	-PRON-	PRP
cord-023417-by18aczt	676	12	have	have	VBP
cord-023417-by18aczt	676	13	developed	develop	VBN
cord-023417-by18aczt	676	14	a	a	DT
cord-023417-by18aczt	676	15	relational	relational	JJ
cord-023417-by18aczt	676	16	database	database	NN
cord-023417-by18aczt	676	17	solution	solution	NN
cord-023417-by18aczt	676	18	for	for	IN
cord-023417-by18aczt	676	19	management	management	NN
cord-023417-by18aczt	676	20	of	of	IN
cord-023417-by18aczt	676	21	laboratory	laboratory	NN
cord-023417-by18aczt	676	22	information	information	NN
cord-023417-by18aczt	676	23	.	.	.
cord-023417-by18aczt	677	1	The	the	DT
cord-023417-by18aczt	677	2	system	system	NN
cord-023417-by18aczt	677	3	consists	consist	VBZ
cord-023417-by18aczt	677	4	of	of	IN
cord-023417-by18aczt	677	5	a	a	DT
cord-023417-by18aczt	677	6	hierarchy	hierarchy	NN
cord-023417-by18aczt	677	7	of	of	IN
cord-023417-by18aczt	677	8	five	five	CD
cord-023417-by18aczt	677	9	interrelated	interrelated	JJ
cord-023417-by18aczt	677	10	databases	database	NNS
cord-023417-by18aczt	677	11	,	,	,
cord-023417-by18aczt	677	12	each	each	DT
cord-023417-by18aczt	677	13	pertaining	pertain	VBG
cord-023417-by18aczt	677	14	to	to	IN
cord-023417-by18aczt	677	15	a	a	DT
cord-023417-by18aczt	677	16	separate	separate	JJ
cord-023417-by18aczt	677	17	type	type	NN
cord-023417-by18aczt	677	18	of	of	IN
cord-023417-by18aczt	677	19	information	information	NN
cord-023417-by18aczt	677	20	,	,	,
cord-023417-by18aczt	677	21	namely	namely	RB
cord-023417-by18aczt	677	22	,	,	,
cord-023417-by18aczt	677	23	overall	overall	JJ
cord-023417-by18aczt	677	24	project	project	NN
cord-023417-by18aczt	677	25	information	information	NN
cord-023417-by18aczt	677	26	,	,	,
cord-023417-by18aczt	677	27	information	information	NN
cord-023417-by18aczt	677	28	relating	relate	VBG
cord-023417-by18aczt	677	29	to	to	IN
cord-023417-by18aczt	677	30	individual	individual	JJ
cord-023417-by18aczt	677	31	experiment	experiment	NN
cord-023417-by18aczt	677	32	setups	setup	NNS
cord-023417-by18aczt	677	33	,	,	,
cord-023417-by18aczt	677	34	documentation	documentation	NN
cord-023417-by18aczt	677	35	of	of	IN
cord-023417-by18aczt	677	36	daily	daily	JJ
cord-023417-by18aczt	677	37	research	research	NN
cord-023417-by18aczt	677	38	activity	activity	NN
cord-023417-by18aczt	677	39	,	,	,
cord-023417-by18aczt	677	40	generated	generate	VBD
cord-023417-by18aczt	677	41	data	datum	NNS
cord-023417-by18aczt	677	42	and	and	CC
cord-023417-by18aczt	677	43	descriptions	description	NNS
cord-023417-by18aczt	677	44	of	of	IN
cord-023417-by18aczt	677	45	standard	standard	JJ
cord-023417-by18aczt	677	46	operating	operating	NN
cord-023417-by18aczt	677	47	procedures	procedure	NNS
cord-023417-by18aczt	677	48	.	.	.
cord-023417-by18aczt	678	1	Like	like	IN
cord-023417-by18aczt	678	2	other	other	JJ
cord-023417-by18aczt	678	3	databases	database	NNS
cord-023417-by18aczt	678	4	,	,	,
cord-023417-by18aczt	678	5	each	each	DT
cord-023417-by18aczt	678	6	individual	individual	JJ
cord-023417-by18aczt	678	7	database	database	NN
cord-023417-by18aczt	678	8	consists	consist	VBZ
cord-023417-by18aczt	678	9	of	of	IN
cord-023417-by18aczt	678	10	a	a	DT
cord-023417-by18aczt	678	11	number	number	NN
cord-023417-by18aczt	678	12	of	of	IN
cord-023417-by18aczt	678	13	records	record	NNS
cord-023417-by18aczt	678	14	,	,	,
cord-023417-by18aczt	678	15	each	each	DT
cord-023417-by18aczt	678	16	comprised	comprise	VBN
cord-023417-by18aczt	678	17	of	of	IN
cord-023417-by18aczt	678	18	a	a	DT
cord-023417-by18aczt	678	19	set	set	NN
cord-023417-by18aczt	678	20	of	of	IN
cord-023417-by18aczt	678	21	fields	field	NNS
cord-023417-by18aczt	678	22	in	in	IN
cord-023417-by18aczt	678	23	which	which	WDT
cord-023417-by18aczt	678	24	information	information	NN
cord-023417-by18aczt	678	25	is	be	VBZ
cord-023417-by18aczt	678	26	entered	enter	VBN
cord-023417-by18aczt	678	27	.	.	.
cord-023417-by18aczt	679	1	In	in	IN
cord-023417-by18aczt	679	2	each	each	DT
cord-023417-by18aczt	679	3	record	record	NN
cord-023417-by18aczt	679	4	,	,	,
cord-023417-by18aczt	679	5	a	a	DT
cord-023417-by18aczt	679	6	certain	certain	JJ
cord-023417-by18aczt	679	7	field	field	NN
cord-023417-by18aczt	679	8	is	be	VBZ
cord-023417-by18aczt	679	9	reserved	reserve	VBN
cord-023417-by18aczt	679	10	to	to	TO
cord-023417-by18aczt	679	11	specify	specify	VB
cord-023417-by18aczt	679	12	the	the	DT
cord-023417-by18aczt	679	13	relation	relation	NN
cord-023417-by18aczt	679	14	of	of	IN
cord-023417-by18aczt	679	15	the	the	DT
cord-023417-by18aczt	679	16	record	record	NN
cord-023417-by18aczt	679	17	to	to	IN
cord-023417-by18aczt	679	18	a	a	DT
cord-023417-by18aczt	679	19	record	record	NN
cord-023417-by18aczt	679	20	in	in	IN
cord-023417-by18aczt	679	21	another	another	DT
cord-023417-by18aczt	679	22	database	database	NN
cord-023417-by18aczt	679	23	at	at	IN
cord-023417-by18aczt	679	24	a	a	DT
cord-023417-by18aczt	679	25	higher	high	JJR
cord-023417-by18aczt	679	26	level	level	NN
cord-023417-by18aczt	679	27	.	.	.
cord-023417-by18aczt	680	1	Thus	thus	RB
cord-023417-by18aczt	680	2	,	,	,
cord-023417-by18aczt	680	3	the	the	DT
cord-023417-by18aczt	680	4	database	database	NN
cord-023417-by18aczt	680	5	is	be	VBZ
cord-023417-by18aczt	680	6	essentially	essentially	RB
cord-023417-by18aczt	680	7	five	five	CD
cord-023417-by18aczt	680	8	databases	database	NNS
cord-023417-by18aczt	680	9	linked	link	VBN
cord-023417-by18aczt	680	10	by	by	IN
cord-023417-by18aczt	680	11	a	a	DT
cord-023417-by18aczt	680	12	hierarchy	hierarchy	NN
cord-023417-by18aczt	680	13	of	of	IN
cord-023417-by18aczt	680	14	one	one	CD
cord-023417-by18aczt	680	15	-	-	HYPH
cord-023417-by18aczt	680	16	to	to	IN
cord-023417-by18aczt	680	17	-	-	HYPH
cord-023417-by18aczt	680	18	many	many	JJ
cord-023417-by18aczt	680	19	relations	relation	NNS
cord-023417-by18aczt	680	20	,	,	,
cord-023417-by18aczt	680	21	organizing	organize	VBG
cord-023417-by18aczt	680	22	information	information	NN
cord-023417-by18aczt	680	23	in	in	IN
cord-023417-by18aczt	680	24	a	a	DT
cord-023417-by18aczt	680	25	folder	folder	NN
cord-023417-by18aczt	680	26	-	-	HYPH
cord-023417-by18aczt	680	27	like	like	JJ
cord-023417-by18aczt	680	28	structure	structure	NN
cord-023417-by18aczt	680	29	.	.	.
cord-023417-by18aczt	681	1	Importantly	importantly	RB
cord-023417-by18aczt	681	2	,	,	,
cord-023417-by18aczt	681	3	the	the	DT
cord-023417-by18aczt	681	4	database	database	NN
cord-023417-by18aczt	681	5	system	system	NN
cord-023417-by18aczt	681	6	allows	allow	VBZ
cord-023417-by18aczt	681	7	multiple	multiple	JJ
cord-023417-by18aczt	681	8	users	user	NNS
cord-023417-by18aczt	681	9	to	to	TO
cord-023417-by18aczt	681	10	access	access	VB
cord-023417-by18aczt	681	11	and	and	CC
cord-023417-by18aczt	681	12	edit	edit	VB
cord-023417-by18aczt	681	13	records	record	NNS
cord-023417-by18aczt	681	14	simultaneously	simultaneously	RB
cord-023417-by18aczt	681	15	,	,	,
cord-023417-by18aczt	681	16	and	and	CC
cord-023417-by18aczt	681	17	the	the	DT
cord-023417-by18aczt	681	18	data	datum	NNS
cord-023417-by18aczt	681	19	entered	enter	VBD
cord-023417-by18aczt	681	20	in	in	IN
cord-023417-by18aczt	681	21	one	one	CD
cord-023417-by18aczt	681	22	database	database	NN
cord-023417-by18aczt	681	23	immediately	immediately	RB
cord-023417-by18aczt	681	24	becomes	become	VBZ
cord-023417-by18aczt	681	25	accessible	accessible	JJ
cord-023417-by18aczt	681	26	through	through	IN
cord-023417-by18aczt	681	27	the	the	DT
cord-023417-by18aczt	681	28	other	other	JJ
cord-023417-by18aczt	681	29	databases	database	NNS
cord-023417-by18aczt	681	30	.	.	.
cord-023417-by18aczt	682	1	The	the	DT
cord-023417-by18aczt	682	2	limitations	limitation	NNS
cord-023417-by18aczt	682	3	of	of	IN
cord-023417-by18aczt	682	4	laboratory	laboratory	NN
cord-023417-by18aczt	682	5	notebooks	notebook	NNS
cord-023417-by18aczt	682	6	are	be	VBP
cord-023417-by18aczt	682	7	apparent	apparent	JJ
cord-023417-by18aczt	682	8	when	when	WRB
cord-023417-by18aczt	682	9	looking	look	VBG
cord-023417-by18aczt	682	10	for	for	IN
cord-023417-by18aczt	682	11	information	information	NN
cord-023417-by18aczt	682	12	,	,	,
cord-023417-by18aczt	682	13	which	which	WDT
cord-023417-by18aczt	682	14	is	be	VBZ
cord-023417-by18aczt	682	15	dispersed	disperse	VBN
cord-023417-by18aczt	682	16	throughout	throughout	IN
cord-023417-by18aczt	682	17	one	one	CD
cord-023417-by18aczt	682	18	or	or	CC
cord-023417-by18aczt	682	19	more	more	JJR
cord-023417-by18aczt	682	20	notebooks	notebook	NNS
cord-023417-by18aczt	682	21	,	,	,
cord-023417-by18aczt	682	22	or	or	CC
cord-023417-by18aczt	682	23	possibly	possibly	RB
cord-023417-by18aczt	682	24	on	on	IN
cord-023417-by18aczt	682	25	loose	loose	JJ
cord-023417-by18aczt	682	26	sheets	sheet	NNS
cord-023417-by18aczt	682	27	of	of	IN
cord-023417-by18aczt	682	28	paper	paper	NN
cord-023417-by18aczt	682	29	or	or	CC
cord-023417-by18aczt	682	30	printouts	printout	NNS
cord-023417-by18aczt	682	31	'	'	POS
cord-023417-by18aczt	682	32	somewhere	somewhere	RB
cord-023417-by18aczt	682	33	'	'	''
cord-023417-by18aczt	682	34	.	.	.
cord-023417-by18aczt	683	1	The	the	DT
cord-023417-by18aczt	683	2	often	often	RB
cord-023417-by18aczt	683	3	complicated	complicated	JJ
cord-023417-by18aczt	683	4	process	process	NN
cord-023417-by18aczt	683	5	of	of	IN
cord-023417-by18aczt	683	6	gathering	gather	VBG
cord-023417-by18aczt	683	7	laboratory	laboratory	NN
cord-023417-by18aczt	683	8	data	datum	NNS
cord-023417-by18aczt	683	9	or	or	CC
cord-023417-by18aczt	683	10	results	result	NNS
cord-023417-by18aczt	683	11	when	when	WRB
cord-023417-by18aczt	683	12	writing	write	VBG
cord-023417-by18aczt	683	13	grant	grant	NN
cord-023417-by18aczt	683	14	applications	application	NNS
cord-023417-by18aczt	683	15	or	or	CC
cord-023417-by18aczt	683	16	research	research	NN
cord-023417-by18aczt	683	17	papers	paper	NNS
cord-023417-by18aczt	683	18	is	be	VBZ
cord-023417-by18aczt	683	19	made	make	VBN
cord-023417-by18aczt	683	20	considerably	considerably	RB
cord-023417-by18aczt	683	21	easier	easy	JJR
cord-023417-by18aczt	683	22	with	with	IN
cord-023417-by18aczt	683	23	the	the	DT
cord-023417-by18aczt	683	24	database	database	NN
cord-023417-by18aczt	683	25	system	system	NN
cord-023417-by18aczt	683	26	.	.	.
cord-023417-by18aczt	684	1	Thus	thus	RB
cord-023417-by18aczt	684	2	,	,	,
cord-023417-by18aczt	684	3	the	the	DT
cord-023417-by18aczt	684	4	database	database	NN
cord-023417-by18aczt	684	5	solution	solution	NN
cord-023417-by18aczt	684	6	presented	present	VBN
cord-023417-by18aczt	684	7	should	should	MD
cord-023417-by18aczt	684	8	be	be	VB
cord-023417-by18aczt	684	9	broadly	broadly	RB
cord-023417-by18aczt	684	10	attractive	attractive	JJ
cord-023417-by18aczt	684	11	to	to	IN
cord-023417-by18aczt	684	12	researchers	researcher	NNS
cord-023417-by18aczt	684	13	,	,	,
cord-023417-by18aczt	684	14	irrespective	irrespective	RB
cord-023417-by18aczt	684	15	of	of	IN
cord-023417-by18aczt	684	16	their	-PRON-	PRP$
cord-023417-by18aczt	684	17	scientific	scientific	JJ
cord-023417-by18aczt	684	18	discipline	discipline	NN
cord-023417-by18aczt	684	19	.	.	.
cord-023417-by18aczt	685	1	An	an	DT
cord-023417-by18aczt	685	2	effective	effective	JJ
cord-023417-by18aczt	685	3	SARS	SARS	NNP
cord-023417-by18aczt	685	4	vaccine	vaccine	NN
cord-023417-by18aczt	685	5	is	be	VBZ
cord-023417-by18aczt	685	6	likely	likely	JJ
cord-023417-by18aczt	685	7	to	to	TO
cord-023417-by18aczt	685	8	include	include	VB
cord-023417-by18aczt	685	9	components	component	NNS
cord-023417-by18aczt	685	10	that	that	WDT
cord-023417-by18aczt	685	11	can	can	MD
cord-023417-by18aczt	685	12	induce	induce	VB
cord-023417-by18aczt	685	13	specific	specific	JJ
cord-023417-by18aczt	685	14	cytotoxic	cytotoxic	JJ
cord-023417-by18aczt	685	15	T	t	NN
cord-023417-by18aczt	685	16	-	-	HYPH
cord-023417-by18aczt	685	17	cell	cell	NN
cord-023417-by18aczt	685	18	(	(	-LRB-
cord-023417-by18aczt	685	19	CTL	CTL	NNP
cord-023417-by18aczt	685	20	)	)	-RRB-
cord-023417-by18aczt	685	21	responses	response	NNS
cord-023417-by18aczt	685	22	.	.	.
cord-023417-by18aczt	686	1	The	the	DT
cord-023417-by18aczt	686	2	specificities	specificity	NNS
cord-023417-by18aczt	686	3	of	of	IN
cord-023417-by18aczt	686	4	such	such	JJ
cord-023417-by18aczt	686	5	responses	response	NNS
cord-023417-by18aczt	686	6	are	be	VBP
cord-023417-by18aczt	686	7	governed	govern	VBN
cord-023417-by18aczt	686	8	by	by	IN
cord-023417-by18aczt	686	9	HLArestricted	hlarestricted	JJ
cord-023417-by18aczt	686	10	presentation	presentation	NN
cord-023417-by18aczt	686	11	of	of	IN
cord-023417-by18aczt	686	12	SARS	SARS	NNP
cord-023417-by18aczt	686	13	-	-	HYPH
cord-023417-by18aczt	686	14	derived	derive	VBN
cord-023417-by18aczt	686	15	peptide	peptide	NN
cord-023417-by18aczt	686	16	epitopes	epitope	NNS
cord-023417-by18aczt	686	17	.	.	.
cord-023417-by18aczt	687	1	Exact	exact	JJ
cord-023417-by18aczt	687	2	knowledge	knowledge	NN
cord-023417-by18aczt	687	3	of	of	IN
cord-023417-by18aczt	687	4	how	how	WRB
cord-023417-by18aczt	687	5	the	the	DT
cord-023417-by18aczt	687	6	immune	immune	JJ
cord-023417-by18aczt	687	7	system	system	NN
cord-023417-by18aczt	687	8	handles	handle	VBZ
cord-023417-by18aczt	687	9	protein	protein	NN
cord-023417-by18aczt	687	10	antigens	antigen	NNS
cord-023417-by18aczt	687	11	would	would	MD
cord-023417-by18aczt	687	12	allow	allow	VB
cord-023417-by18aczt	687	13	for	for	IN
cord-023417-by18aczt	687	14	the	the	DT
cord-023417-by18aczt	687	15	identification	identification	NN
cord-023417-by18aczt	687	16	of	of	IN
cord-023417-by18aczt	687	17	such	such	JJ
cord-023417-by18aczt	687	18	linear	linear	JJ
cord-023417-by18aczt	687	19	sequences	sequence	NNS
cord-023417-by18aczt	687	20	directly	directly	RB
cord-023417-by18aczt	687	21	from	from	IN
cord-023417-by18aczt	687	22	genomic	genomic	JJ
cord-023417-by18aczt	687	23	/	/	SYM
cord-023417-by18aczt	687	24	proteomic	proteomic	JJ
cord-023417-by18aczt	687	25	sequence	sequence	NN
cord-023417-by18aczt	687	26	information	information	NN
cord-023417-by18aczt	687	27	.	.	.
cord-023417-by18aczt	688	1	The	the	DT
cord-023417-by18aczt	688	2	latter	latter	JJ
cord-023417-by18aczt	688	3	was	be	VBD
cord-023417-by18aczt	688	4	recently	recently	RB
cord-023417-by18aczt	688	5	established	establish	VBN
cord-023417-by18aczt	688	6	when	when	WRB
cord-023417-by18aczt	688	7	a	a	DT
cord-023417-by18aczt	688	8	causative	causative	JJ
cord-023417-by18aczt	688	9	coronavirus	coronavirus	NN
cord-023417-by18aczt	688	10	(	(	-LRB-
cord-023417-by18aczt	688	11	SARS	SARS	NNP
cord-023417-by18aczt	688	12	CoV	CoV	NNP
cord-023417-by18aczt	688	13	)	)	-RRB-
cord-023417-by18aczt	688	14	was	be	VBD
cord-023417-by18aczt	688	15	isolated	isolate	VBN
cord-023417-by18aczt	688	16	and	and	CC
cord-023417-by18aczt	688	17	full	full	JJ
cord-023417-by18aczt	688	18	-	-	HYPH
cord-023417-by18aczt	688	19	length	length	NN
cord-023417-by18aczt	688	20	sequenced	sequence	VBN
cord-023417-by18aczt	688	21	.	.	.
cord-023417-by18aczt	689	1	Here	here	RB
cord-023417-by18aczt	689	2	,	,	,
cord-023417-by18aczt	689	3	we	-PRON-	PRP
cord-023417-by18aczt	689	4	have	have	VBP
cord-023417-by18aczt	689	5	combined	combine	VBN
cord-023417-by18aczt	689	6	advanced	advanced	JJ
cord-023417-by18aczt	689	7	bioinformatics	bioinformatic	NNS
cord-023417-by18aczt	689	8	and	and	CC
cord-023417-by18aczt	689	9	high	high	JJ
cord-023417-by18aczt	689	10	-	-	HYPH
cord-023417-by18aczt	689	11	throughput	throughput	NN
cord-023417-by18aczt	689	12	immunology	immunology	NN
cord-023417-by18aczt	689	13	to	to	TO
cord-023417-by18aczt	689	14	perform	perform	VB
cord-023417-by18aczt	689	15	an	an	DT
cord-023417-by18aczt	689	16	HLA	HLA	NNP
cord-023417-by18aczt	689	17	supertype	supertype	NN
cord-023417-by18aczt	689	18	,	,	,
cord-023417-by18aczt	689	19	genome	genome	NN
cord-023417-by18aczt	689	20	-	-	HYPH
cord-023417-by18aczt	689	21	wide	wide	JJ
cord-023417-by18aczt	689	22	scan	scan	NN
cord-023417-by18aczt	689	23	for	for	IN
cord-023417-by18aczt	689	24	SARS	SARS	NNP
cord-023417-by18aczt	689	25	-	-	HYPH
cord-023417-by18aczt	689	26	specific	specific	JJ
cord-023417-by18aczt	689	27	cytotoxic	cytotoxic	JJ
cord-023417-by18aczt	689	28	T	t	NN
cord-023417-by18aczt	689	29	cell	cell	NN
cord-023417-by18aczt	689	30	epitopes	epitope	NNS
cord-023417-by18aczt	689	31	.	.	.
cord-023417-by18aczt	690	1	The	the	DT
cord-023417-by18aczt	690	2	scan	scan	NN
cord-023417-by18aczt	690	3	includes	include	VBZ
cord-023417-by18aczt	690	4	all	all	DT
cord-023417-by18aczt	690	5	nine	nine	CD
cord-023417-by18aczt	690	6	human	human	JJ
cord-023417-by18aczt	690	7	HLA	HLA	NNP
cord-023417-by18aczt	690	8	supertypes	supertype	NNS
cord-023417-by18aczt	690	9	in	in	IN
cord-023417-by18aczt	690	10	total	total	JJ
cord-023417-by18aczt	690	11	covering	covering	NN
cord-023417-by18aczt	690	12	>	>	SYM
cord-023417-by18aczt	690	13	99	99	CD
cord-023417-by18aczt	690	14	%	%	NN
cord-023417-by18aczt	690	15	of	of	IN
cord-023417-by18aczt	690	16	all	all	DT
cord-023417-by18aczt	690	17	major	major	JJ
cord-023417-by18aczt	690	18	human	human	JJ
cord-023417-by18aczt	690	19	populations	population	NNS
cord-023417-by18aczt	690	20	.	.	.
cord-023417-by18aczt	691	1	For	for	IN
cord-023417-by18aczt	691	2	each	each	DT
cord-023417-by18aczt	691	3	HLA	HLA	NNP
cord-023417-by18aczt	691	4	supertype	supertype	NN
cord-023417-by18aczt	691	5	,	,	,
cord-023417-by18aczt	691	6	we	-PRON-	PRP
cord-023417-by18aczt	691	7	have	have	VBP
cord-023417-by18aczt	691	8	selected	select	VBN
cord-023417-by18aczt	691	9	the	the	DT
cord-023417-by18aczt	691	10	15	15	CD
cord-023417-by18aczt	691	11	top	top	JJ
cord-023417-by18aczt	691	12	candidates	candidate	NNS
cord-023417-by18aczt	691	13	for	for	IN
cord-023417-by18aczt	691	14	test	test	NN
cord-023417-by18aczt	691	15	in	in	IN
cord-023417-by18aczt	691	16	biochemical	biochemical	JJ
cord-023417-by18aczt	691	17	-	-	HYPH
cord-023417-by18aczt	691	18	binding	bind	VBG
cord-023417-by18aczt	691	19	assays	assay	NNS
cord-023417-by18aczt	691	20	.	.	.
cord-023417-by18aczt	692	1	At	at	IN
cord-023417-by18aczt	692	2	this	this	DT
cord-023417-by18aczt	692	3	time	time	NN
cord-023417-by18aczt	692	4	(	(	-LRB-
cord-023417-by18aczt	692	5	approximately	approximately	RB
cord-023417-by18aczt	692	6	6	6	CD
cord-023417-by18aczt	692	7	months	month	NNS
cord-023417-by18aczt	692	8	after	after	IN
cord-023417-by18aczt	692	9	the	the	DT
cord-023417-by18aczt	692	10	genome	genome	NN
cord-023417-by18aczt	692	11	was	be	VBD
cord-023417-by18aczt	692	12	established	establish	VBN
cord-023417-by18aczt	692	13	)	)	-RRB-
cord-023417-by18aczt	692	14	,	,	,
cord-023417-by18aczt	692	15	we	-PRON-	PRP
cord-023417-by18aczt	692	16	have	have	VBP
cord-023417-by18aczt	692	17	tested	test	VBN
cord-023417-by18aczt	692	18	the	the	DT
cord-023417-by18aczt	692	19	majority	majority	NN
cord-023417-by18aczt	692	20	of	of	IN
cord-023417-by18aczt	692	21	the	the	DT
cord-023417-by18aczt	692	22	HLA	HLA	NNP
cord-023417-by18aczt	692	23	supertypes	supertype	NNS
cord-023417-by18aczt	692	24	and	and	CC
cord-023417-by18aczt	692	25	identified	identify	VBD
cord-023417-by18aczt	692	26	almost	almost	RB
cord-023417-by18aczt	692	27	100	100	CD
cord-023417-by18aczt	692	28	potential	potential	JJ
cord-023417-by18aczt	692	29	vaccine	vaccine	NN
cord-023417-by18aczt	692	30	candidates	candidate	NNS
cord-023417-by18aczt	692	31	.	.	.
cord-023417-by18aczt	693	1	These	these	DT
cord-023417-by18aczt	693	2	should	should	MD
cord-023417-by18aczt	693	3	be	be	VB
cord-023417-by18aczt	693	4	further	further	RB
cord-023417-by18aczt	693	5	validated	validate	VBN
cord-023417-by18aczt	693	6	in	in	IN
cord-023417-by18aczt	693	7	SARS	SARS	NNP
cord-023417-by18aczt	693	8	survivors	survivor	NNS
cord-023417-by18aczt	693	9	and	and	CC
cord-023417-by18aczt	693	10	used	use	VBD
cord-023417-by18aczt	693	11	for	for	IN
cord-023417-by18aczt	693	12	vaccine	vaccine	NN
cord-023417-by18aczt	693	13	formulation	formulation	NN
cord-023417-by18aczt	693	14	.	.	.
cord-023417-by18aczt	694	1	We	-PRON-	PRP
cord-023417-by18aczt	694	2	suggest	suggest	VBP
cord-023417-by18aczt	694	3	that	that	IN
cord-023417-by18aczt	694	4	immunobioinformatics	immunobioinformatic	NNS
cord-023417-by18aczt	694	5	may	may	MD
cord-023417-by18aczt	694	6	become	become	VB
cord-023417-by18aczt	694	7	a	a	DT
cord-023417-by18aczt	694	8	fast	fast	JJ
cord-023417-by18aczt	694	9	and	and	CC
cord-023417-by18aczt	694	10	valuable	valuable	JJ
cord-023417-by18aczt	694	11	tool	tool	NN
cord-023417-by18aczt	694	12	in	in	IN
cord-023417-by18aczt	694	13	rational	rational	JJ
cord-023417-by18aczt	694	14	vaccine	vaccine	NN
cord-023417-by18aczt	694	15	design	design	NN
cord-023417-by18aczt	694	16	.	.	.
cord-023417-by18aczt	695	1	Rationale	rationale	NN
cord-023417-by18aczt	695	2	:	:	:
cord-023417-by18aczt	696	1	Major	major	JJ
cord-023417-by18aczt	696	2	histocompatibility	histocompatibility	NN
cord-023417-by18aczt	696	3	complex	complex	NN
cord-023417-by18aczt	696	4	class	class	NN
cord-023417-by18aczt	697	1	I	-PRON-	PRP
cord-023417-by18aczt	697	2	(	(	-LRB-
cord-023417-by18aczt	697	3	MHC	MHC	NNP
cord-023417-by18aczt	697	4	I	I	NNP
cord-023417-by18aczt	697	5	)	)	-RRB-
cord-023417-by18aczt	697	6	molecules	molecule	NNS
cord-023417-by18aczt	697	7	monitor	monitor	VBP
cord-023417-by18aczt	697	8	the	the	DT
cord-023417-by18aczt	697	9	protein	protein	NN
cord-023417-by18aczt	697	10	content	content	NN
cord-023417-by18aczt	697	11	of	of	IN
cord-023417-by18aczt	697	12	the	the	DT
cord-023417-by18aczt	697	13	cell	cell	NN
cord-023417-by18aczt	697	14	by	by	IN
cord-023417-by18aczt	697	15	binding	bind	VBG
cord-023417-by18aczt	697	16	small	small	JJ
cord-023417-by18aczt	697	17	derived	derive	VBN
cord-023417-by18aczt	697	18	peptides	peptide	NNS
cord-023417-by18aczt	697	19	and	and	CC
cord-023417-by18aczt	697	20	presenting	present	VBG
cord-023417-by18aczt	697	21	them	-PRON-	PRP
cord-023417-by18aczt	697	22	to	to	IN
cord-023417-by18aczt	697	23	cytotoxic	cytotoxic	JJ
cord-023417-by18aczt	697	24	CD8	CD8	NNP
cord-023417-by18aczt	697	25	þ	þ	NNP
cord-023417-by18aczt	697	26	T	T	NNP
cord-023417-by18aczt	697	27	cells	cell	NNS
cord-023417-by18aczt	697	28	.	.	.
cord-023417-by18aczt	698	1	The	the	DT
cord-023417-by18aczt	698	2	goal	goal	NN
cord-023417-by18aczt	698	3	of	of	IN
cord-023417-by18aczt	698	4	the	the	DT
cord-023417-by18aczt	698	5	human	human	JJ
cord-023417-by18aczt	698	6	MHC	MHC	NNP
cord-023417-by18aczt	698	7	project	project	NN
cord-023417-by18aczt	698	8	is	be	VBZ
cord-023417-by18aczt	698	9	to	to	TO
cord-023417-by18aczt	698	10	predict	predict	VB
cord-023417-by18aczt	698	11	the	the	DT
cord-023417-by18aczt	698	12	binding	binding	NN
cord-023417-by18aczt	698	13	strength	strength	NN
cord-023417-by18aczt	698	14	of	of	IN
cord-023417-by18aczt	698	15	any	any	DT
cord-023417-by18aczt	698	16	given	give	VBN
cord-023417-by18aczt	698	17	peptide	peptide	NN
cord-023417-by18aczt	698	18	/	/	SYM
cord-023417-by18aczt	698	19	MHC	MHC	NNP
cord-023417-by18aczt	698	20	complex	complex	NN
cord-023417-by18aczt	698	21	.	.	.
cord-023417-by18aczt	699	1	This	this	DT
cord-023417-by18aczt	699	2	prediction	prediction	NN
cord-023417-by18aczt	699	3	allows	allow	VBZ
cord-023417-by18aczt	699	4	the	the	DT
cord-023417-by18aczt	699	5	design	design	NN
cord-023417-by18aczt	699	6	of	of	IN
cord-023417-by18aczt	699	7	peptide	peptide	NN
cord-023417-by18aczt	699	8	-	-	HYPH
cord-023417-by18aczt	699	9	based	base	VBN
cord-023417-by18aczt	699	10	vaccines	vaccine	NNS
cord-023417-by18aczt	699	11	.	.	.
cord-023417-by18aczt	700	1	The	the	DT
cord-023417-by18aczt	700	2	prediction	prediction	NN
cord-023417-by18aczt	700	3	requires	require	VBZ
cord-023417-by18aczt	700	4	representative	representative	JJ
cord-023417-by18aczt	700	5	binding	bind	VBG
cord-023417-by18aczt	700	6	data	datum	NNS
cord-023417-by18aczt	700	7	from	from	IN
cord-023417-by18aczt	700	8	MHC	MHC	NNP
cord-023417-by18aczt	700	9	alleles	allele	NNS
cord-023417-by18aczt	700	10	from	from	IN
cord-023417-by18aczt	700	11	all	all	PDT
cord-023417-by18aczt	700	12	the	the	DT
cord-023417-by18aczt	700	13	nine	nine	CD
cord-023417-by18aczt	700	14	HLA	HLA	NNP
cord-023417-by18aczt	700	15	supertypes	supertype	NNS
cord-023417-by18aczt	700	16	.	.	.
cord-023417-by18aczt	701	1	Here	here	RB
cord-023417-by18aczt	701	2	,	,	,
cord-023417-by18aczt	701	3	we	-PRON-	PRP
cord-023417-by18aczt	701	4	describe	describe	VBP
cord-023417-by18aczt	701	5	the	the	DT
cord-023417-by18aczt	701	6	genetic	genetic	JJ
cord-023417-by18aczt	701	7	construction	construction	NN
cord-023417-by18aczt	701	8	,	,	,
cord-023417-by18aczt	701	9	protein	protein	NN
cord-023417-by18aczt	701	10	production	production	NN
cord-023417-by18aczt	701	11	and	and	CC
cord-023417-by18aczt	701	12	purification	purification	NN
cord-023417-by18aczt	701	13	as	as	RB
cord-023417-by18aczt	701	14	well	well	RB
cord-023417-by18aczt	701	15	as	as	IN
cord-023417-by18aczt	701	16	the	the	DT
cord-023417-by18aczt	701	17	establishment	establishment	NN
cord-023417-by18aczt	701	18	-	-	HYPH
cord-023417-by18aczt	701	19	binding	bind	VBG
cord-023417-by18aczt	701	20	assays	assay	NNS
cord-023417-by18aczt	701	21	for	for	IN
cord-023417-by18aczt	701	22	two	two	CD
cord-023417-by18aczt	701	23	recombinant	recombinant	JJ
cord-023417-by18aczt	701	24	MHC	MHC	NNP
cord-023417-by18aczt	701	25	supertype	supertype	NN
cord-023417-by18aczt	701	26	alleles	allele	NNS
cord-023417-by18aczt	701	27	,	,	,
cord-023417-by18aczt	701	28	HLA	HLA	NNP
cord-023417-by18aczt	701	29	-	-	HYPH
cord-023417-by18aczt	701	30	B*1501	B*1501	NNP
cord-023417-by18aczt	701	31	and	and	CC
cord-023417-by18aczt	701	32	HLA	HLA	NNP
cord-023417-by18aczt	701	33	-	-	HYPH
cord-023417-by18aczt	701	34	B*5801	B*5801	NNP
cord-023417-by18aczt	701	35	.	.	.
cord-023417-by18aczt	702	1	Methods	method	NNS
cord-023417-by18aczt	702	2	:	:	:
cord-023417-by18aczt	702	3	Using	use	VBG
cord-023417-by18aczt	702	4	the	the	DT
cord-023417-by18aczt	702	5	Quikchange	Quikchange	NNP
cord-023417-by18aczt	702	6	Multisite	Multisite	NNP
cord-023417-by18aczt	702	7	Directed	Directed	NNP
cord-023417-by18aczt	702	8	Mutagenesis	Mutagenesis	NNP
cord-023417-by18aczt	702	9	Kit	kit	NN
cord-023417-by18aczt	702	10	(	(	-LRB-
cord-023417-by18aczt	702	11	Stratagene	Stratagene	NNP
cord-023417-by18aczt	702	12	)	)	-RRB-
cord-023417-by18aczt	702	13	,	,	,
cord-023417-by18aczt	702	14	codon	codon	NN
cord-023417-by18aczt	702	15	-	-	HYPH
cord-023417-by18aczt	702	16	optimized	optimize	VBN
cord-023417-by18aczt	702	17	genes	gene	NNS
cord-023417-by18aczt	702	18	encoding	encode	VBG
cord-023417-by18aczt	702	19	HLA	HLA	NNP
cord-023417-by18aczt	702	20	-	-	HYPH
cord-023417-by18aczt	702	21	B*1501	B*1501	NNP
cord-023417-by18aczt	702	22	and	and	CC
cord-023417-by18aczt	702	23	HLA	HLA	NNP
cord-023417-by18aczt	702	24	-	-	HYPH
cord-023417-by18aczt	702	25	B*5801	B*5801	NNP
cord-023417-by18aczt	702	26	are	be	VBP
cord-023417-by18aczt	702	27	created	create	VBN
cord-023417-by18aczt	702	28	.	.	.
cord-023417-by18aczt	703	1	The	the	DT
cord-023417-by18aczt	703	2	two	two	CD
cord-023417-by18aczt	703	3	MHC	MHC	NNP
cord-023417-by18aczt	703	4	I	-PRON-	PRP
cord-023417-by18aczt	703	5	molecules	molecule	NNS
cord-023417-by18aczt	703	6	are	be	VBP
cord-023417-by18aczt	703	7	fermented	ferment	VBN
cord-023417-by18aczt	703	8	and	and	CC
cord-023417-by18aczt	703	9	purified	purify	VBN
cord-023417-by18aczt	703	10	by	by	IN
cord-023417-by18aczt	703	11	ion	ion	NN
cord-023417-by18aczt	703	12	exchange	exchange	NN
cord-023417-by18aczt	703	13	chromatography	chromatography	NN
cord-023417-by18aczt	703	14	,	,	,
cord-023417-by18aczt	703	15	hydrophobic	hydrophobic	JJ
cord-023417-by18aczt	703	16	interaction	interaction	NN
cord-023417-by18aczt	703	17	chromatography	chromatography	NN
cord-023417-by18aczt	703	18	and	and	CC
cord-023417-by18aczt	703	19	size	size	NN
cord-023417-by18aczt	703	20	exclusion	exclusion	NN
cord-023417-by18aczt	703	21	chromatography	chromatography	NN
cord-023417-by18aczt	703	22	.	.	.
cord-023417-by18aczt	704	1	The	the	DT
cord-023417-by18aczt	704	2	binding	binding	NN
cord-023417-by18aczt	704	3	(	(	-LRB-
cord-023417-by18aczt	704	4	KD	KD	NNP
cord-023417-by18aczt	704	5	)	)	-RRB-
cord-023417-by18aczt	704	6	of	of	IN
cord-023417-by18aczt	704	7	natural	natural	JJ
cord-023417-by18aczt	704	8	T	T	NNP
cord-023417-by18aczt	704	9	-	-	HYPH
cord-023417-by18aczt	704	10	cell	cell	NN
cord-023417-by18aczt	704	11	epitopes	epitope	NNS
cord-023417-by18aczt	704	12	,	,	,
cord-023417-by18aczt	704	13	as	as	RB
cord-023417-by18aczt	704	14	well	well	RB
cord-023417-by18aczt	704	15	as	as	IN
cord-023417-by18aczt	704	16	predicted	predict	VBN
cord-023417-by18aczt	704	17	peptide	peptide	NN
cord-023417-by18aczt	704	18	ligands	ligand	NNS
cord-023417-by18aczt	704	19	,	,	,
cord-023417-by18aczt	704	20	is	be	VBZ
cord-023417-by18aczt	704	21	described	describe	VBN
cord-023417-by18aczt	704	22	by	by	IN
cord-023417-by18aczt	704	23	radioactive	radioactive	JJ
cord-023417-by18aczt	704	24	immunoassays	immunoassay	NNS
cord-023417-by18aczt	704	25	(	(	-LRB-
cord-023417-by18aczt	704	26	RIAs	RIAs	NNP
cord-023417-by18aczt	704	27	)	)	-RRB-
cord-023417-by18aczt	704	28	and	and	CC
cord-023417-by18aczt	704	29	enzyme	enzyme	NN
cord-023417-by18aczt	704	30	-	-	HYPH
cord-023417-by18aczt	704	31	linked	link	VBN
cord-023417-by18aczt	704	32	immunosorbent	immunosorbent	JJ
cord-023417-by18aczt	704	33	assays	assay	NNS
cord-023417-by18aczt	704	34	(	(	-LRB-
cord-023417-by18aczt	704	35	ELISAs	elisa	NNS
cord-023417-by18aczt	704	36	)	)	-RRB-
cord-023417-by18aczt	704	37	.	.	.
cord-023417-by18aczt	705	1	The	the	DT
cord-023417-by18aczt	705	2	MHC	MHC	NNP
cord-023417-by18aczt	705	3	molecules	molecule	NNS
cord-023417-by18aczt	705	4	are	be	VBP
cord-023417-by18aczt	705	5	biotinylated	biotinylate	VBN
cord-023417-by18aczt	705	6	during	during	IN
cord-023417-by18aczt	705	7	expression	expression	NN
cord-023417-by18aczt	705	8	.	.	.
cord-023417-by18aczt	706	1	Results	result	NNS
cord-023417-by18aczt	706	2	:	:	:
cord-023417-by18aczt	707	1	The	the	DT
cord-023417-by18aczt	707	2	expression	expression	NN
cord-023417-by18aczt	707	3	of	of	IN
cord-023417-by18aczt	707	4	MHC	MHC	NNP
cord-023417-by18aczt	707	5	I	-PRON-	PRP
cord-023417-by18aczt	707	6	resulted	result	VBD
cord-023417-by18aczt	707	7	in	in	IN
cord-023417-by18aczt	707	8	multiple	multiple	JJ
cord-023417-by18aczt	707	9	disulfide	disulfide	JJ
cord-023417-by18aczt	707	10	bond	bond	NN
cord-023417-by18aczt	707	11	isomers	isomer	NNS
cord-023417-by18aczt	707	12	,	,	,
cord-023417-by18aczt	707	13	which	which	WDT
cord-023417-by18aczt	707	14	are	be	VBP
cord-023417-by18aczt	707	15	separated	separate	VBN
cord-023417-by18aczt	707	16	by	by	IN
cord-023417-by18aczt	707	17	hydrophobic	hydrophobic	JJ
cord-023417-by18aczt	707	18	interaction	interaction	NN
cord-023417-by18aczt	707	19	chromatography	chromatography	NN
cord-023417-by18aczt	707	20	and	and	CC
cord-023417-by18aczt	707	21	used	use	VBN
cord-023417-by18aczt	707	22	in	in	IN
cord-023417-by18aczt	707	23	subsequent	subsequent	JJ
cord-023417-by18aczt	707	24	binding	binding	NN
cord-023417-by18aczt	707	25	studies	study	NNS
cord-023417-by18aczt	707	26	resulting	result	VBG
cord-023417-by18aczt	707	27	in	in	IN
cord-023417-by18aczt	707	28	the	the	DT
cord-023417-by18aczt	707	29	determination	determination	NN
cord-023417-by18aczt	707	30	of	of	IN
cord-023417-by18aczt	707	31	KD	KD	NNP
cord-023417-by18aczt	707	32	for	for	IN
cord-023417-by18aczt	707	33	various	various	JJ
cord-023417-by18aczt	707	34	peptide	peptide	NN
cord-023417-by18aczt	707	35	ligands	ligand	NNS
cord-023417-by18aczt	707	36	ranging	range	VBG
cord-023417-by18aczt	707	37	from	from	IN
cord-023417-by18aczt	707	38	strong	strong	JJ
cord-023417-by18aczt	707	39	binders	binder	NNS
cord-023417-by18aczt	707	40	We	-PRON-	PRP
cord-023417-by18aczt	707	41	have	have	VBP
cord-023417-by18aczt	707	42	previously	previously	RB
cord-023417-by18aczt	707	43	demonstrated	demonstrate	VBN
cord-023417-by18aczt	707	44	that	that	IN
cord-023417-by18aczt	707	45	bioinformatics	bioinformatics	NN
cord-023417-by18aczt	707	46	tools	tool	NNS
cord-023417-by18aczt	707	47	such	such	JJ
cord-023417-by18aczt	707	48	as	as	IN
cord-023417-by18aczt	707	49	artificial	artificial	JJ
cord-023417-by18aczt	707	50	neural	neural	JJ
cord-023417-by18aczt	707	51	networks	network	NNS
cord-023417-by18aczt	707	52	(	(	-LRB-
cord-023417-by18aczt	707	53	ANNs	ANNs	NNP
cord-023417-by18aczt	707	54	)	)	-RRB-
cord-023417-by18aczt	707	55	are	be	VBP
cord-023417-by18aczt	707	56	capable	capable	JJ
cord-023417-by18aczt	707	57	of	of	IN
cord-023417-by18aczt	707	58	performing	perform	VBG
cord-023417-by18aczt	707	59	pathogen-	pathogen-	NN
cord-023417-by18aczt	707	60	,	,	,
cord-023417-by18aczt	707	61	genome	genome	NN
cord-023417-by18aczt	707	62	-	-	HYPH
cord-023417-by18aczt	707	63	and	and	CC
cord-023417-by18aczt	707	64	HLAwide	hlawide	NN
cord-023417-by18aczt	707	65	predictions	prediction	NNS
cord-023417-by18aczt	707	66	of	of	IN
cord-023417-by18aczt	707	67	peptide	peptide	NN
cord-023417-by18aczt	707	68	-	-	HYPH
cord-023417-by18aczt	707	69	HLA	HLA	NNP
cord-023417-by18aczt	707	70	interactions	interaction	NNS
cord-023417-by18aczt	707	71	.	.	.
cord-023417-by18aczt	708	1	These	these	DT
cord-023417-by18aczt	708	2	tools	tool	NNS
cord-023417-by18aczt	708	3	may	may	MD
cord-023417-by18aczt	708	4	therefore	therefore	RB
cord-023417-by18aczt	708	5	enable	enable	VB
cord-023417-by18aczt	708	6	a	a	DT
cord-023417-by18aczt	708	7	fast	fast	JJ
cord-023417-by18aczt	708	8	and	and	CC
cord-023417-by18aczt	708	9	rational	rational	JJ
cord-023417-by18aczt	708	10	approach	approach	NN
cord-023417-by18aczt	708	11	to	to	IN
cord-023417-by18aczt	708	12	epitope	epitope	NN
cord-023417-by18aczt	708	13	identification	identification	NN
cord-023417-by18aczt	708	14	and	and	CC
cord-023417-by18aczt	708	15	thereby	thereby	RB
cord-023417-by18aczt	708	16	assist	assist	VB
cord-023417-by18aczt	708	17	in	in	IN
cord-023417-by18aczt	708	18	the	the	DT
cord-023417-by18aczt	708	19	development	development	NN
cord-023417-by18aczt	708	20	of	of	IN
cord-023417-by18aczt	708	21	vaccines	vaccine	NNS
cord-023417-by18aczt	708	22	and	and	CC
cord-023417-by18aczt	708	23	immunotherapy	immunotherapy	NN
cord-023417-by18aczt	708	24	.	.	.
cord-023417-by18aczt	709	1	A	a	DT
cord-023417-by18aczt	709	2	crucial	crucial	JJ
cord-023417-by18aczt	709	3	step	step	NN
cord-023417-by18aczt	709	4	in	in	IN
cord-023417-by18aczt	709	5	the	the	DT
cord-023417-by18aczt	709	6	generation	generation	NN
cord-023417-by18aczt	709	7	of	of	IN
cord-023417-by18aczt	709	8	such	such	JJ
cord-023417-by18aczt	709	9	bioinformatics	bioinformatics	NN
cord-023417-by18aczt	709	10	tools	tool	NNS
cord-023417-by18aczt	709	11	is	be	VBZ
cord-023417-by18aczt	709	12	the	the	DT
cord-023417-by18aczt	709	13	selection	selection	NN
cord-023417-by18aczt	709	14	of	of	IN
cord-023417-by18aczt	709	15	data	datum	NNS
cord-023417-by18aczt	709	16	representing	represent	VBG
cord-023417-by18aczt	709	17	the	the	DT
cord-023417-by18aczt	709	18	event	event	NN
cord-023417-by18aczt	709	19	in	in	IN
cord-023417-by18aczt	709	20	question	question	NN
cord-023417-by18aczt	709	21	(	(	-LRB-
cord-023417-by18aczt	709	22	in	in	IN
cord-023417-by18aczt	709	23	casu	casu	NNP
cord-023417-by18aczt	709	24	peptide	peptide	NNP
cord-023417-by18aczt	709	25	-	-	HYPH
cord-023417-by18aczt	709	26	HLA	HLA	NNP
cord-023417-by18aczt	709	27	interaction	interaction	NN
cord-023417-by18aczt	709	28	)	)	-RRB-
cord-023417-by18aczt	709	29	.	.	.
cord-023417-by18aczt	710	1	This	this	DT
cord-023417-by18aczt	710	2	is	be	VBZ
cord-023417-by18aczt	710	3	particularly	particularly	RB
cord-023417-by18aczt	710	4	important	important	JJ
cord-023417-by18aczt	710	5	when	when	WRB
cord-023417-by18aczt	710	6	it	-PRON-	PRP
cord-023417-by18aczt	710	7	is	be	VBZ
cord-023417-by18aczt	710	8	difficult	difficult	JJ
cord-023417-by18aczt	710	9	and	and	CC
cord-023417-by18aczt	710	10	expensive	expensive	JJ
cord-023417-by18aczt	710	11	to	to	TO
cord-023417-by18aczt	710	12	obtain	obtain	VB
cord-023417-by18aczt	710	13	data	datum	NNS
cord-023417-by18aczt	710	14	.	.	.
cord-023417-by18aczt	711	1	Herein	herein	RB
cord-023417-by18aczt	711	2	,	,	,
cord-023417-by18aczt	711	3	we	-PRON-	PRP
cord-023417-by18aczt	711	4	demonstrate	demonstrate	VBP
cord-023417-by18aczt	711	5	the	the	DT
cord-023417-by18aczt	711	6	importance	importance	NN
cord-023417-by18aczt	711	7	in	in	IN
cord-023417-by18aczt	711	8	selecting	select	VBG
cord-023417-by18aczt	711	9	information	information	NN
cord-023417-by18aczt	711	10	-	-	HYPH
cord-023417-by18aczt	711	11	rich	rich	JJ
cord-023417-by18aczt	711	12	data	datum	NNS
cord-023417-by18aczt	711	13	and	and	CC
cord-023417-by18aczt	711	14	we	-PRON-	PRP
cord-023417-by18aczt	711	15	develop	develop	VBP
cord-023417-by18aczt	711	16	a	a	DT
cord-023417-by18aczt	711	17	computational	computational	JJ
cord-023417-by18aczt	711	18	method	method	NN
cord-023417-by18aczt	711	19	,	,	,
cord-023417-by18aczt	711	20	query	query	NN
cord-023417-by18aczt	711	21	-	-	HYPH
cord-023417-by18aczt	711	22	bycommittee	bycommittee	NNP
cord-023417-by18aczt	711	23	,	,	,
cord-023417-by18aczt	711	24	which	which	WDT
cord-023417-by18aczt	711	25	can	can	MD
cord-023417-by18aczt	711	26	perform	perform	VB
cord-023417-by18aczt	711	27	a	a	DT
cord-023417-by18aczt	711	28	global	global	JJ
cord-023417-by18aczt	711	29	identification	identification	NN
cord-023417-by18aczt	711	30	of	of	IN
cord-023417-by18aczt	711	31	such	such	JJ
cord-023417-by18aczt	711	32	information	information	NN
cord-023417-by18aczt	711	33	-	-	HYPH
cord-023417-by18aczt	711	34	rich	rich	JJ
cord-023417-by18aczt	711	35	data	datum	NNS
cord-023417-by18aczt	711	36	in	in	IN
cord-023417-by18aczt	711	37	an	an	DT
cord-023417-by18aczt	711	38	unbiased	unbiased	JJ
cord-023417-by18aczt	711	39	and	and	CC
cord-023417-by18aczt	711	40	automated	automated	JJ
cord-023417-by18aczt	711	41	manner	manner	NN
cord-023417-by18aczt	711	42	.	.	.
cord-023417-by18aczt	712	1	Furthermore	furthermore	RB
cord-023417-by18aczt	712	2	,	,	,
cord-023417-by18aczt	712	3	we	-PRON-	PRP
cord-023417-by18aczt	712	4	demonstrate	demonstrate	VBP
cord-023417-by18aczt	712	5	how	how	WRB
cord-023417-by18aczt	712	6	this	this	DT
cord-023417-by18aczt	712	7	method	method	NN
cord-023417-by18aczt	712	8	can	can	MD
cord-023417-by18aczt	712	9	be	be	VB
cord-023417-by18aczt	712	10	applied	apply	VBN
cord-023417-by18aczt	712	11	to	to	IN
cord-023417-by18aczt	712	12	an	an	DT
cord-023417-by18aczt	712	13	efficient	efficient	JJ
cord-023417-by18aczt	712	14	iterative	iterative	JJ
cord-023417-by18aczt	712	15	development	development	NN
cord-023417-by18aczt	712	16	strategy	strategy	NN
cord-023417-by18aczt	712	17	for	for	IN
cord-023417-by18aczt	712	18	these	these	DT
cord-023417-by18aczt	712	19	bioinformatics	bioinformatics	NN
cord-023417-by18aczt	712	20	tools	tool	NNS
cord-023417-by18aczt	712	21	.	.	.
cord-023417-by18aczt	713	1	Methods	method	NNS
cord-023417-by18aczt	713	2	:	:	:
cord-023417-by18aczt	714	1	A	a	DT
cord-023417-by18aczt	714	2	large	large	JJ
cord-023417-by18aczt	714	3	panel	panel	NN
cord-023417-by18aczt	714	4	of	of	IN
cord-023417-by18aczt	714	5	binding	bind	VBG
cord-023417-by18aczt	714	6	affinities	affinity	NNS
cord-023417-by18aczt	714	7	of	of	IN
cord-023417-by18aczt	714	8	peptides	peptide	NNS
cord-023417-by18aczt	714	9	binding	bind	VBG
cord-023417-by18aczt	714	10	to	to	IN
cord-023417-by18aczt	714	11	HLA	HLA	NNP
cord-023417-by18aczt	714	12	A*0204	A*0204	NNP
cord-023417-by18aczt	714	13	was	be	VBD
cord-023417-by18aczt	714	14	measured	measure	VBN
cord-023417-by18aczt	714	15	by	by	IN
cord-023417-by18aczt	714	16	a	a	DT
cord-023417-by18aczt	714	17	radioimmunoassay	radioimmunoassay	JJ
cord-023417-by18aczt	714	18	(	(	-LRB-
cord-023417-by18aczt	714	19	RIA	RIA	NNP
cord-023417-by18aczt	714	20	)	)	-RRB-
cord-023417-by18aczt	714	21	.	.	.
cord-023417-by18aczt	715	1	This	this	DT
cord-023417-by18aczt	715	2	data	data	NN
cord-023417-by18aczt	715	3	was	be	VBD
cord-023417-by18aczt	715	4	used	use	VBN
cord-023417-by18aczt	715	5	to	to	TO
cord-023417-by18aczt	715	6	develop	develop	VB
cord-023417-by18aczt	715	7	multiple	multiple	JJ
cord-023417-by18aczt	715	8	first	first	JJ
cord-023417-by18aczt	715	9	generation	generation	NN
cord-023417-by18aczt	715	10	ANNs	ANNs	NNP
cord-023417-by18aczt	715	11	,	,	,
cord-023417-by18aczt	715	12	which	which	WDT
cord-023417-by18aczt	715	13	formed	form	VBD
cord-023417-by18aczt	715	14	a	a	DT
cord-023417-by18aczt	715	15	virtual	virtual	JJ
cord-023417-by18aczt	715	16	committee	committee	NN
cord-023417-by18aczt	715	17	.	.	.
cord-023417-by18aczt	716	1	This	this	DT
cord-023417-by18aczt	716	2	committee	committee	NN
cord-023417-by18aczt	716	3	was	be	VBD
cord-023417-by18aczt	716	4	used	use	VBN
cord-023417-by18aczt	716	5	to	to	TO
cord-023417-by18aczt	716	6	screen	screen	VB
cord-023417-by18aczt	716	7	(	(	-LRB-
cord-023417-by18aczt	716	8	or	or	CC
cord-023417-by18aczt	716	9	'	'	``
cord-023417-by18aczt	716	10	queried	query	VBN
cord-023417-by18aczt	716	11	'	'	''
cord-023417-by18aczt	716	12	)	)	-RRB-
cord-023417-by18aczt	716	13	for	for	IN
cord-023417-by18aczt	716	14	peptides	peptide	NNS
cord-023417-by18aczt	716	15	,	,	,
cord-023417-by18aczt	716	16	where	where	WRB
cord-023417-by18aczt	716	17	the	the	DT
cord-023417-by18aczt	716	18	ANNs	ANNs	NNP
cord-023417-by18aczt	716	19	agreed	agree	VBD
cord-023417-by18aczt	716	20	(	(	-LRB-
cord-023417-by18aczt	716	21	'	'	``
cord-023417-by18aczt	716	22	low	low	JJ
cord-023417-by18aczt	716	23	-	-	HYPH
cord-023417-by18aczt	716	24	QBC	QBC	NNP
cord-023417-by18aczt	716	25	'	'	''
cord-023417-by18aczt	716	26	)	)	-RRB-
cord-023417-by18aczt	716	27	,	,	,
cord-023417-by18aczt	716	28	or	or	CC
cord-023417-by18aczt	716	29	disagreed	disagree	VBN
cord-023417-by18aczt	716	30	(	(	-LRB-
cord-023417-by18aczt	716	31	'	'	``
cord-023417-by18aczt	716	32	high	high	JJ
cord-023417-by18aczt	716	33	-	-	HYPH
cord-023417-by18aczt	716	34	QBC	QBC	NNP
cord-023417-by18aczt	716	35	'	'	''
cord-023417-by18aczt	716	36	)	)	-RRB-
cord-023417-by18aczt	716	37	,	,	,
cord-023417-by18aczt	716	38	on	on	IN
cord-023417-by18aczt	716	39	their	-PRON-	PRP$
cord-023417-by18aczt	716	40	HLA	HLA	NNP
cord-023417-by18aczt	716	41	-	-	HYPH
cord-023417-by18aczt	716	42	binding	bind	VBG
cord-023417-by18aczt	716	43	potential	potential	NN
cord-023417-by18aczt	716	44	.	.	.
cord-023417-by18aczt	717	1	Seventeen	seventeen	CD
cord-023417-by18aczt	717	2	low	low	JJ
cord-023417-by18aczt	717	3	-	-	HYPH
cord-023417-by18aczt	717	4	QBC	QBC	NNP
cord-023417-by18aczt	717	5	peptides	peptide	NNS
cord-023417-by18aczt	717	6	and	and	CC
cord-023417-by18aczt	717	7	17	17	CD
cord-023417-by18aczt	717	8	high	high	JJ
cord-023417-by18aczt	717	9	-	-	HYPH
cord-023417-by18aczt	717	10	QBC	QBC	NNP
cord-023417-by18aczt	717	11	peptides	peptide	NNS
cord-023417-by18aczt	717	12	were	be	VBD
cord-023417-by18aczt	717	13	synthesized	synthesize	VBN
cord-023417-by18aczt	717	14	and	and	CC
cord-023417-by18aczt	717	15	tested	test	VBN
cord-023417-by18aczt	717	16	.	.	.
cord-023417-by18aczt	718	1	The	the	DT
cord-023417-by18aczt	718	2	high	high	JJ
cord-023417-by18aczt	718	3	-	-	HYPH
cord-023417-by18aczt	718	4	or	or	CC
cord-023417-by18aczt	718	5	low	low	JJ
cord-023417-by18aczt	718	6	-	-	HYPH
cord-023417-by18aczt	718	7	QBC	QBC	NNP
cord-023417-by18aczt	718	8	data	datum	NNS
cord-023417-by18aczt	718	9	were	be	VBD
cord-023417-by18aczt	718	10	added	add	VBN
cord-023417-by18aczt	718	11	to	to	IN
cord-023417-by18aczt	718	12	the	the	DT
cord-023417-by18aczt	718	13	original	original	JJ
cord-023417-by18aczt	718	14	data	datum	NNS
cord-023417-by18aczt	718	15	,	,	,
cord-023417-by18aczt	718	16	and	and	CC
cord-023417-by18aczt	718	17	new	new	JJ
cord-023417-by18aczt	718	18	high	high	JJ
cord-023417-by18aczt	718	19	-	-	HYPH
cord-023417-by18aczt	718	20	or	or	CC
cord-023417-by18aczt	718	21	low	low	JJ
cord-023417-by18aczt	718	22	-	-	HYPH
cord-023417-by18aczt	718	23	QBC	QBC	NNP
cord-023417-by18aczt	718	24	second	second	JJ
cord-023417-by18aczt	718	25	generation	generation	NN
cord-023417-by18aczt	718	26	ANNs	ANNs	NNPS
cord-023417-by18aczt	718	27	were	be	VBD
cord-023417-by18aczt	718	28	developed	develop	VBN
cord-023417-by18aczt	718	29	,	,	,
cord-023417-by18aczt	718	30	respectively	respectively	RB
cord-023417-by18aczt	718	31	.	.	.
cord-023417-by18aczt	719	1	This	this	DT
cord-023417-by18aczt	719	2	procedure	procedure	NN
cord-023417-by18aczt	719	3	was	be	VBD
cord-023417-by18aczt	719	4	repeated	repeat	VBN
cord-023417-by18aczt	719	5	40	40	CD
cord-023417-by18aczt	719	6	times	time	NNS
cord-023417-by18aczt	719	7	.	.	.
cord-023417-by18aczt	720	1	The	the	DT
cord-023417-by18aczt	720	2	high	high	JJ
cord-023417-by18aczt	720	3	-	-	HYPH
cord-023417-by18aczt	720	4	QBC	qbc	NN
cord-023417-by18aczt	720	5	-	-	HYPH
cord-023417-by18aczt	720	6	enriched	enrich	VBN
cord-023417-by18aczt	720	7	ANN	ANN	NNP
cord-023417-by18aczt	720	8	performed	perform	VBD
cord-023417-by18aczt	720	9	significantly	significantly	RB
cord-023417-by18aczt	720	10	better	well	RBR
cord-023417-by18aczt	720	11	than	than	IN
cord-023417-by18aczt	720	12	the	the	DT
cord-023417-by18aczt	720	13	low	low	JJ
cord-023417-by18aczt	720	14	-	-	HYPH
cord-023417-by18aczt	720	15	QBC	qbc	NN
cord-023417-by18aczt	720	16	-	-	HYPH
cord-023417-by18aczt	720	17	enriched	enrich	VBN
cord-023417-by18aczt	720	18	ANN	ANN	NNP
cord-023417-by18aczt	720	19	in	in	IN
cord-023417-by18aczt	720	20	37	37	CD
cord-023417-by18aczt	720	21	of	of	IN
cord-023417-by18aczt	720	22	the	the	DT
cord-023417-by18aczt	720	23	40	40	CD
cord-023417-by18aczt	720	24	tests	test	NNS
cord-023417-by18aczt	720	25	.	.	.
cord-023417-by18aczt	721	1	Conclusion	conclusion	NN
cord-023417-by18aczt	721	2	:	:	:
cord-023417-by18aczt	722	1	These	these	DT
cord-023417-by18aczt	722	2	results	result	NNS
cord-023417-by18aczt	722	3	demonstrate	demonstrate	VBP
cord-023417-by18aczt	722	4	that	that	IN
cord-023417-by18aczt	722	5	high	high	JJ
cord-023417-by18aczt	722	6	-	-	HYPH
cord-023417-by18aczt	722	7	QBCenriched	qbcenriched	NN
cord-023417-by18aczt	722	8	networks	network	NNS
cord-023417-by18aczt	722	9	perform	perform	VBP
cord-023417-by18aczt	722	10	better	well	JJR
cord-023417-by18aczt	722	11	than	than	IN
cord-023417-by18aczt	722	12	low	low	JJ
cord-023417-by18aczt	722	13	-	-	HYPH
cord-023417-by18aczt	722	14	QBC	qbc	NN
cord-023417-by18aczt	722	15	-	-	HYPH
cord-023417-by18aczt	722	16	enriched	enrich	VBN
cord-023417-by18aczt	722	17	networks	network	NNS
cord-023417-by18aczt	722	18	in	in	IN
cord-023417-by18aczt	722	19	selecting	select	VBG
cord-023417-by18aczt	722	20	informative	informative	JJ
cord-023417-by18aczt	722	21	data	datum	NNS
cord-023417-by18aczt	722	22	for	for	IN
cord-023417-by18aczt	722	23	developing	develop	VBG
cord-023417-by18aczt	722	24	peptide	peptide	JJ
cord-023417-by18aczt	722	25	-	-	HYPH
cord-023417-by18aczt	722	26	MHC	MHC	NNP
cord-023417-by18aczt	722	27	-	-	HYPH
cord-023417-by18aczt	722	28	binding	bind	VBG
cord-023417-by18aczt	722	29	predictors	predictor	NNS
cord-023417-by18aczt	722	30	.	.	.
cord-023417-by18aczt	723	1	This	this	DT
cord-023417-by18aczt	723	2	improvement	improvement	NN
cord-023417-by18aczt	723	3	in	in	IN
cord-023417-by18aczt	723	4	selecting	select	VBG
cord-023417-by18aczt	723	5	data	datum	NNS
cord-023417-by18aczt	723	6	is	be	VBZ
cord-023417-by18aczt	723	7	not	not	RB
cord-023417-by18aczt	723	8	due	due	JJ
cord-023417-by18aczt	723	9	to	to	IN
cord-023417-by18aczt	723	10	differences	difference	NNS
cord-023417-by18aczt	723	11	in	in	IN
cord-023417-by18aczt	723	12	network	network	NN
cord-023417-by18aczt	723	13	training	training	NN
cord-023417-by18aczt	723	14	performance	performance	NN
cord-023417-by18aczt	723	15	but	but	CC
cord-023417-by18aczt	723	16	due	due	IN
cord-023417-by18aczt	723	17	to	to	IN
cord-023417-by18aczt	723	18	the	the	DT
cord-023417-by18aczt	723	19	difference	difference	NN
cord-023417-by18aczt	723	20	in	in	IN
cord-023417-by18aczt	723	21	information	information	NN
cord-023417-by18aczt	723	22	content	content	NN
cord-023417-by18aczt	723	23	in	in	IN
cord-023417-by18aczt	723	24	the	the	DT
cord-023417-by18aczt	723	25	high	high	JJ
cord-023417-by18aczt	723	26	-	-	HYPH
cord-023417-by18aczt	723	27	QBC	QBC	NNP
cord-023417-by18aczt	723	28	experiment	experiment	NN
cord-023417-by18aczt	723	29	and	and	CC
cord-023417-by18aczt	723	30	in	in	IN
cord-023417-by18aczt	723	31	the	the	DT
cord-023417-by18aczt	723	32	low	low	JJ
cord-023417-by18aczt	723	33	-	-	HYPH
cord-023417-by18aczt	723	34	QBC	QBC	NNP
cord-023417-by18aczt	723	35	experiment	experiment	NN
cord-023417-by18aczt	723	36	.	.	.
cord-023417-by18aczt	724	1	Finally	finally	RB
cord-023417-by18aczt	724	2	,	,	,
cord-023417-by18aczt	724	3	it	-PRON-	PRP
cord-023417-by18aczt	724	4	should	should	MD
cord-023417-by18aczt	724	5	be	be	VB
cord-023417-by18aczt	724	6	noted	note	VBN
cord-023417-by18aczt	724	7	that	that	IN
cord-023417-by18aczt	724	8	this	this	DT
cord-023417-by18aczt	724	9	strategy	strategy	NN
cord-023417-by18aczt	724	10	could	could	MD
cord-023417-by18aczt	724	11	be	be	VB
cord-023417-by18aczt	724	12	used	use	VBN
cord-023417-by18aczt	724	13	in	in	IN
cord-023417-by18aczt	724	14	many	many	JJ
cord-023417-by18aczt	724	15	contexts	context	NNS
cord-023417-by18aczt	724	16	where	where	WRB
cord-023417-by18aczt	724	17	generation	generation	NN
cord-023417-by18aczt	724	18	of	of	IN
cord-023417-by18aczt	724	19	data	datum	NNS
cord-023417-by18aczt	724	20	is	be	VBZ
cord-023417-by18aczt	724	21	difficult	difficult	JJ
cord-023417-by18aczt	724	22	and	and	CC
cord-023417-by18aczt	724	23	costly	costly	JJ
cord-023417-by18aczt	724	24	.	.	.
cord-023417-by18aczt	725	1	Interleukin-18	Interleukin-18	NNP
cord-023417-by18aczt	725	2	(	(	-LRB-
cord-023417-by18aczt	725	3	IL-18	IL-18	NNP
cord-023417-by18aczt	725	4	)	)	-RRB-
cord-023417-by18aczt	725	5	,	,	,
cord-023417-by18aczt	725	6	a	a	DT
cord-023417-by18aczt	725	7	pro	pro	JJ
cord-023417-by18aczt	725	8	-	-	JJ
cord-023417-by18aczt	725	9	inflammatory	inflammatory	JJ
cord-023417-by18aczt	725	10	cytokine	cytokine	NN
cord-023417-by18aczt	725	11	that	that	WDT
cord-023417-by18aczt	725	12	is	be	VBZ
cord-023417-by18aczt	725	13	produced	produce	VBN
cord-023417-by18aczt	725	14	by	by	IN
cord-023417-by18aczt	725	15	both	both	DT
cord-023417-by18aczt	725	16	lymphoid	lymphoid	NNP
cord-023417-by18aczt	725	17	and	and	CC
cord-023417-by18aczt	725	18	nonlymphoid	nonlymphoid	NNP
cord-023417-by18aczt	725	19	cells	cell	NNS
cord-023417-by18aczt	725	20	,	,	,
cord-023417-by18aczt	725	21	has	have	VBZ
cord-023417-by18aczt	725	22	a	a	DT
cord-023417-by18aczt	725	23	critical	critical	JJ
cord-023417-by18aczt	725	24	role	role	NN
cord-023417-by18aczt	725	25	in	in	IN
cord-023417-by18aczt	725	26	modulation	modulation	NN
cord-023417-by18aczt	725	27	of	of	IN
cord-023417-by18aczt	725	28	innate	innate	JJ
cord-023417-by18aczt	725	29	and	and	CC
cord-023417-by18aczt	725	30	adaptive	adaptive	JJ
cord-023417-by18aczt	725	31	immunity	immunity	NN
cord-023417-by18aczt	725	32	.	.	.
cord-023417-by18aczt	726	1	Its	-PRON-	PRP$
cord-023417-by18aczt	726	2	primary	primary	JJ
cord-023417-by18aczt	726	3	function	function	NN
cord-023417-by18aczt	726	4	in	in	IN
cord-023417-by18aczt	726	5	stimulation	stimulation	NN
cord-023417-by18aczt	726	6	of	of	IN
cord-023417-by18aczt	726	7	IFN	IFN	NNP
cord-023417-by18aczt	726	8	-	-	HYPH
cord-023417-by18aczt	726	9	g	g	NN
cord-023417-by18aczt	726	10	production	production	NN
cord-023417-by18aczt	726	11	and	and	CC
cord-023417-by18aczt	726	12	stimulation	stimulation	NN
cord-023417-by18aczt	726	13	of	of	IN
cord-023417-by18aczt	726	14	NK	nk	NN
cord-023417-by18aczt	726	15	-	-	HYPH
cord-023417-by18aczt	726	16	cell	cell	NN
cord-023417-by18aczt	726	17	-	-	HYPH
cord-023417-by18aczt	726	18	cytotoxic	cytotoxic	JJ
cord-023417-by18aczt	726	19	activities	activity	NNS
cord-023417-by18aczt	726	20	makes	make	VBZ
cord-023417-by18aczt	726	21	this	this	DT
cord-023417-by18aczt	726	22	cytokine	cytokine	NN
cord-023417-by18aczt	726	23	a	a	DT
cord-023417-by18aczt	726	24	candidate	candidate	NN
cord-023417-by18aczt	726	25	for	for	IN
cord-023417-by18aczt	726	26	cancer	cancer	NN
cord-023417-by18aczt	726	27	immunotherapy	immunotherapy	NN
cord-023417-by18aczt	726	28	.	.	.
cord-023417-by18aczt	727	1	In	in	IN
cord-023417-by18aczt	727	2	oral	oral	JJ
cord-023417-by18aczt	727	3	cavity	cavity	NN
cord-023417-by18aczt	727	4	,	,	,
cord-023417-by18aczt	727	5	this	this	DT
cord-023417-by18aczt	727	6	cytokine	cytokine	NN
cord-023417-by18aczt	727	7	is	be	VBZ
cord-023417-by18aczt	727	8	produced	produce	VBN
cord-023417-by18aczt	727	9	by	by	IN
cord-023417-by18aczt	727	10	oral	oral	JJ
cord-023417-by18aczt	727	11	epithelia	epithelium	NNS
cord-023417-by18aczt	727	12	and	and	CC
cord-023417-by18aczt	727	13	carcinoma	carcinoma	NN
cord-023417-by18aczt	727	14	cells	cell	NNS
cord-023417-by18aczt	727	15	and	and	CC
cord-023417-by18aczt	727	16	is	be	VBZ
cord-023417-by18aczt	727	17	related	relate	VBN
cord-023417-by18aczt	727	18	to	to	IN
cord-023417-by18aczt	727	19	tumour	tumour	NN
cord-023417-by18aczt	727	20	regression	regression	NN
cord-023417-by18aczt	727	21	in	in	IN
cord-023417-by18aczt	727	22	nude	nude	JJ
cord-023417-by18aczt	727	23	mice	mouse	NNS
cord-023417-by18aczt	727	24	bearing	bear	VBG
cord-023417-by18aczt	727	25	salivary	salivary	JJ
cord-023417-by18aczt	727	26	adenocarcinoma	adenocarcinoma	NN
cord-023417-by18aczt	727	27	.	.	.
cord-023417-by18aczt	728	1	However	however	RB
cord-023417-by18aczt	728	2	,	,	,
cord-023417-by18aczt	728	3	direct	direct	JJ
cord-023417-by18aczt	728	4	effects	effect	NNS
cord-023417-by18aczt	728	5	of	of	IN
cord-023417-by18aczt	728	6	this	this	DT
cord-023417-by18aczt	728	7	cytokine	cytokine	NN
cord-023417-by18aczt	728	8	on	on	IN
cord-023417-by18aczt	728	9	oral	oral	JJ
cord-023417-by18aczt	728	10	cancer	cancer	NN
cord-023417-by18aczt	728	11	cells	cell	NNS
cord-023417-by18aczt	728	12	have	have	VBP
cord-023417-by18aczt	728	13	not	not	RB
cord-023417-by18aczt	728	14	been	be	VBN
cord-023417-by18aczt	728	15	elucidated	elucidate	VBN
cord-023417-by18aczt	728	16	.	.	.
cord-023417-by18aczt	729	1	In	in	IN
cord-023417-by18aczt	729	2	this	this	DT
cord-023417-by18aczt	729	3	project	project	NN
cord-023417-by18aczt	729	4	,	,	,
cord-023417-by18aczt	729	5	we	-PRON-	PRP
cord-023417-by18aczt	729	6	investigated	investigate	VBD
cord-023417-by18aczt	729	7	IL-18	IL-18	NNP
cord-023417-by18aczt	729	8	effect	effect	NN
cord-023417-by18aczt	729	9	on	on	IN
cord-023417-by18aczt	729	10	an	an	DT
cord-023417-by18aczt	729	11	oral	oral	JJ
cord-023417-by18aczt	729	12	carcinoma	carcinoma	NN
cord-023417-by18aczt	729	13	(	(	-LRB-
cord-023417-by18aczt	729	14	KB	KB	NNP
cord-023417-by18aczt	729	15	)	)	-RRB-
cord-023417-by18aczt	729	16	cell	cell	NN
cord-023417-by18aczt	729	17	line	line	NN
cord-023417-by18aczt	729	18	.	.	.
cord-023417-by18aczt	730	1	With	with	IN
cord-023417-by18aczt	730	2	RT	RT	NNP
cord-023417-by18aczt	730	3	-	-	HYPH
cord-023417-by18aczt	730	4	PCR	PCR	NNP
cord-023417-by18aczt	730	5	technique	technique	NN
cord-023417-by18aczt	730	6	,	,	,
cord-023417-by18aczt	730	7	KB	kb	NN
cord-023417-by18aczt	730	8	-	-	HYPH
cord-023417-by18aczt	730	9	cell	cell	NN
cord-023417-by18aczt	730	10	line	line	NN
cord-023417-by18aczt	730	11	was	be	VBD
cord-023417-by18aczt	730	12	found	find	VBN
cord-023417-by18aczt	730	13	to	to	TO
cord-023417-by18aczt	730	14	express	express	VB
cord-023417-by18aczt	730	15	IL-18	IL-18	NNP
cord-023417-by18aczt	730	16	receptors	receptor	NNS
cord-023417-by18aczt	730	17	(	(	-LRB-
cord-023417-by18aczt	730	18	IL-18Ra	IL-18Ra	NNP
cord-023417-by18aczt	730	19	and	and	CC
cord-023417-by18aczt	730	20	IL-18Rb	IL-18Rb	NNP
cord-023417-by18aczt	730	21	)	)	-RRB-
cord-023417-by18aczt	730	22	,	,	,
cord-023417-by18aczt	730	23	indicating	indicate	VBG
cord-023417-by18aczt	730	24	that	that	IN
cord-023417-by18aczt	730	25	this	this	DT
cord-023417-by18aczt	730	26	oral	oral	JJ
cord-023417-by18aczt	730	27	carcinoma	carcinoma	NN
cord-023417-by18aczt	730	28	line	line	NN
cord-023417-by18aczt	730	29	is	be	VBZ
cord-023417-by18aczt	730	30	a	a	DT
cord-023417-by18aczt	730	31	target	target	NN
cord-023417-by18aczt	730	32	for	for	IN
cord-023417-by18aczt	730	33	IL-18	IL-18	NNP
cord-023417-by18aczt	730	34	study	study	NN
cord-023417-by18aczt	730	35	.	.	.
cord-023417-by18aczt	731	1	We	-PRON-	PRP
cord-023417-by18aczt	731	2	showed	show	VBD
cord-023417-by18aczt	731	3	that	that	IN
cord-023417-by18aczt	731	4	recombinant	recombinant	JJ
cord-023417-by18aczt	731	5	human	human	NN
cord-023417-by18aczt	731	6	IL-18	IL-18	NNP
cord-023417-by18aczt	731	7	inhibited	inhibited	JJ
cord-023417-by18aczt	731	8	KB	KB	NNP
cord-023417-by18aczt	731	9	-	-	HYPH
cord-023417-by18aczt	731	10	cell	cell	NN
cord-023417-by18aczt	731	11	proliferation	proliferation	NN
cord-023417-by18aczt	731	12	by	by	IN
cord-023417-by18aczt	731	13	17	17	CD
cord-023417-by18aczt	731	14	%	%	NN
cord-023417-by18aczt	731	15	at	at	IN
cord-023417-by18aczt	731	16	concentration	concentration	NN
cord-023417-by18aczt	731	17	of	of	IN
cord-023417-by18aczt	731	18	100	100	CD
cord-023417-by18aczt	731	19	ng	ng	NN
cord-023417-by18aczt	731	20	/	/	SYM
cord-023417-by18aczt	731	21	ml	ml	NN
cord-023417-by18aczt	731	22	(	(	-LRB-
cord-023417-by18aczt	731	23	P	p	NN
cord-023417-by18aczt	731	24	<	<	XX
cord-023417-by18aczt	731	25	0.05	0.05	CD
cord-023417-by18aczt	731	26	)	)	-RRB-
cord-023417-by18aczt	731	27	,	,	,
cord-023417-by18aczt	731	28	whereas	whereas	IN
cord-023417-by18aczt	731	29	LDH	LDH	NNP
cord-023417-by18aczt	731	30	release	release	NN
cord-023417-by18aczt	731	31	by	by	IN
cord-023417-by18aczt	731	32	these	these	DT
cord-023417-by18aczt	731	33	cells	cell	NNS
cord-023417-by18aczt	731	34	in	in	IN
cord-023417-by18aczt	731	35	treatment	treatment	NN
cord-023417-by18aczt	731	36	group	group	NN
cord-023417-by18aczt	731	37	and	and	CC
cord-023417-by18aczt	731	38	control	control	NN
cord-023417-by18aczt	731	39	groups	group	NNS
cord-023417-by18aczt	731	40	was	be	VBD
cord-023417-by18aczt	731	41	comparable	comparable	JJ
cord-023417-by18aczt	731	42	,	,	,
cord-023417-by18aczt	731	43	indicating	indicate	VBG
cord-023417-by18aczt	731	44	that	that	IN
cord-023417-by18aczt	731	45	IL-18	IL-18	NNP
cord-023417-by18aczt	731	46	suppression	suppression	NN
cord-023417-by18aczt	731	47	of	of	IN
cord-023417-by18aczt	731	48	cell	cell	NN
cord-023417-by18aczt	731	49	proliferation	proliferation	NN
cord-023417-by18aczt	731	50	was	be	VBD
cord-023417-by18aczt	731	51	not	not	RB
cord-023417-by18aczt	731	52	mediated	mediate	VBN
cord-023417-by18aczt	731	53	by	by	IN
cord-023417-by18aczt	731	54	the	the	DT
cord-023417-by18aczt	731	55	induction	induction	NN
cord-023417-by18aczt	731	56	of	of	IN
cord-023417-by18aczt	731	57	cell	cell	NN
cord-023417-by18aczt	731	58	death	death	NN
cord-023417-by18aczt	731	59	.	.	.
cord-023417-by18aczt	732	1	To	to	TO
cord-023417-by18aczt	732	2	further	further	RB
cord-023417-by18aczt	732	3	address	address	VB
cord-023417-by18aczt	732	4	this	this	DT
cord-023417-by18aczt	732	5	hypothesis	hypothesis	NN
cord-023417-by18aczt	732	6	,	,	,
cord-023417-by18aczt	732	7	we	-PRON-	PRP
cord-023417-by18aczt	732	8	found	find	VBD
cord-023417-by18aczt	732	9	that	that	IN
cord-023417-by18aczt	732	10	IL-18	IL-18	NNP
cord-023417-by18aczt	732	11	treatment	treatment	NN
cord-023417-by18aczt	732	12	did	do	VBD
cord-023417-by18aczt	732	13	not	not	RB
cord-023417-by18aczt	732	14	induce	induce	VB
cord-023417-by18aczt	732	15	apoptotic	apoptotic	JJ
cord-023417-by18aczt	732	16	cell	cell	NN
cord-023417-by18aczt	732	17	death	death	NN
cord-023417-by18aczt	732	18	,	,	,
cord-023417-by18aczt	732	19	as	as	IN
cord-023417-by18aczt	732	20	studied	study	VBN
cord-023417-by18aczt	732	21	by	by	IN
cord-023417-by18aczt	732	22	DNA	dna	NN
cord-023417-by18aczt	732	23	laddering	laddering	NN
cord-023417-by18aczt	732	24	and	and	CC
cord-023417-by18aczt	732	25	TUNEL	TUNEL	NNP
cord-023417-by18aczt	732	26	assays	assay	NNS
cord-023417-by18aczt	732	27	.	.	.
cord-023417-by18aczt	733	1	In	in	IN
cord-023417-by18aczt	733	2	addition	addition	NN
cord-023417-by18aczt	733	3	,	,	,
cord-023417-by18aczt	733	4	expression	expression	NN
cord-023417-by18aczt	733	5	pattern	pattern	NN
cord-023417-by18aczt	733	6	of	of	IN
cord-023417-by18aczt	733	7	cell	cell	NN
cord-023417-by18aczt	733	8	death	death	NN
cord-023417-by18aczt	733	9	-	-	HYPH
cord-023417-by18aczt	733	10	controlling	control	VBG
cord-023417-by18aczt	733	11	genes	gene	NNS
cord-023417-by18aczt	733	12	(	(	-LRB-
cord-023417-by18aczt	733	13	bcl-2	bcl-2	NNP
cord-023417-by18aczt	733	14	and	and	CC
cord-023417-by18aczt	733	15	bax	bax	NNP
cord-023417-by18aczt	733	16	)	)	-RRB-
cord-023417-by18aczt	733	17	was	be	VBD
cord-023417-by18aczt	733	18	not	not	RB
cord-023417-by18aczt	733	19	altered	alter	VBN
cord-023417-by18aczt	733	20	by	by	IN
cord-023417-by18aczt	733	21	this	this	DT
cord-023417-by18aczt	733	22	cytokine	cytokine	NN
cord-023417-by18aczt	733	23	.	.	.
cord-023417-by18aczt	734	1	Findings	finding	NNS
cord-023417-by18aczt	734	2	in	in	IN
cord-023417-by18aczt	734	3	these	these	DT
cord-023417-by18aczt	734	4	studies	study	NNS
cord-023417-by18aczt	734	5	indicated	indicate	VBD
cord-023417-by18aczt	734	6	that	that	IN
cord-023417-by18aczt	734	7	suppression	suppression	NN
cord-023417-by18aczt	734	8	of	of	IN
cord-023417-by18aczt	734	9	KB	kb	NN
cord-023417-by18aczt	734	10	-	-	HYPH
cord-023417-by18aczt	734	11	cell	cell	NN
cord-023417-by18aczt	734	12	proliferation	proliferation	NN
cord-023417-by18aczt	734	13	may	may	MD
cord-023417-by18aczt	734	14	be	be	VB
cord-023417-by18aczt	734	15	attributed	attribute	VBN
cord-023417-by18aczt	734	16	to	to	IN
cord-023417-by18aczt	734	17	control	control	NN
cord-023417-by18aczt	734	18	of	of	IN
cord-023417-by18aczt	734	19	cell	cell	NN
cord-023417-by18aczt	734	20	cycle	cycle	NN
cord-023417-by18aczt	734	21	,	,	,
cord-023417-by18aczt	734	22	growth	growth	NN
cord-023417-by18aczt	734	23	arrest	arrest	NN
cord-023417-by18aczt	734	24	or	or	CC
cord-023417-by18aczt	734	25	induction	induction	NN
cord-023417-by18aczt	734	26	of	of	IN
cord-023417-by18aczt	734	27	cell	cell	NN
cord-023417-by18aczt	734	28	differentiation	differentiation	NN
cord-023417-by18aczt	734	29	.	.	.
cord-023417-by18aczt	735	1	The	the	DT
cord-023417-by18aczt	735	2	data	datum	NNS
cord-023417-by18aczt	735	3	presented	present	VBN
cord-023417-by18aczt	735	4	in	in	IN
cord-023417-by18aczt	735	5	this	this	DT
cord-023417-by18aczt	735	6	project	project	NN
cord-023417-by18aczt	735	7	could	could	MD
cord-023417-by18aczt	735	8	provide	provide	VB
cord-023417-by18aczt	735	9	an	an	DT
cord-023417-by18aczt	735	10	insight	insight	NN
cord-023417-by18aczt	735	11	of	of	IN
cord-023417-by18aczt	735	12	how	how	WRB
cord-023417-by18aczt	735	13	cancer	cancer	NN
cord-023417-by18aczt	735	14	cell	cell	NN
cord-023417-by18aczt	735	15	directly	directly	RB
cord-023417-by18aczt	735	16	responds	respond	VBZ
cord-023417-by18aczt	735	17	to	to	IN
cord-023417-by18aczt	735	18	IL-18	IL-18	NNP
cord-023417-by18aczt	735	19	,	,	,
cord-023417-by18aczt	735	20	as	as	IN
cord-023417-by18aczt	735	21	this	this	DT
cord-023417-by18aczt	735	22	cytokine	cytokine	NN
cord-023417-by18aczt	735	23	is	be	VBZ
cord-023417-by18aczt	735	24	an	an	DT
cord-023417-by18aczt	735	25	important	important	JJ
cord-023417-by18aczt	735	26	regulator	regulator	NN
cord-023417-by18aczt	735	27	of	of	IN
cord-023417-by18aczt	735	28	anticancer	anticancer	JJ
cord-023417-by18aczt	735	29	mechanisms	mechanism	NNS
cord-023417-by18aczt	735	30	.	.	.
cord-023417-by18aczt	736	1	Aloe	aloe	NN
cord-023417-by18aczt	736	2	emodin	emodin	NNS
cord-023417-by18aczt	736	3	(	(	-LRB-
cord-023417-by18aczt	736	4	AE	AE	NNP
cord-023417-by18aczt	736	5	)	)	-RRB-
cord-023417-by18aczt	736	6	is	be	VBZ
cord-023417-by18aczt	736	7	a	a	DT
cord-023417-by18aczt	736	8	naturally	naturally	RB
cord-023417-by18aczt	736	9	occurring	occur	VBG
cord-023417-by18aczt	736	10	compound	compound	NN
cord-023417-by18aczt	736	11	with	with	IN
cord-023417-by18aczt	736	12	wide	wide	JJ
cord-023417-by18aczt	736	13	spectrum	spectrum	NN
cord-023417-by18aczt	736	14	of	of	IN
cord-023417-by18aczt	736	15	biological	biological	JJ
cord-023417-by18aczt	736	16	properties	property	NNS
cord-023417-by18aczt	736	17	,	,	,
cord-023417-by18aczt	736	18	including	include	VBG
cord-023417-by18aczt	736	19	antimicrobial	antimicrobial	JJ
cord-023417-by18aczt	736	20	,	,	,
cord-023417-by18aczt	736	21	vasorelaxant	vasorelaxant	JJ
cord-023417-by18aczt	736	22	,	,	,
cord-023417-by18aczt	736	23	immunosuppressive	immunosuppressive	JJ
cord-023417-by18aczt	736	24	and	and	CC
cord-023417-by18aczt	736	25	anticancer	anticancer	JJ
cord-023417-by18aczt	736	26	actions	action	NNS
cord-023417-by18aczt	736	27	.	.	.
cord-023417-by18aczt	737	1	This	this	DT
cord-023417-by18aczt	737	2	anthraquinone	anthraquinone	NN
cord-023417-by18aczt	737	3	induces	induce	VBZ
cord-023417-by18aczt	737	4	apoptosis	apoptosis	NN
cord-023417-by18aczt	737	5	in	in	IN
cord-023417-by18aczt	737	6	several	several	JJ
cord-023417-by18aczt	737	7	tumour	tumour	NN
cord-023417-by18aczt	737	8	cell	cell	NN
cord-023417-by18aczt	737	9	lines	line	NNS
cord-023417-by18aczt	737	10	with	with	IN
cord-023417-by18aczt	737	11	special	special	JJ
cord-023417-by18aczt	737	12	affinity	affinity	NN
cord-023417-by18aczt	737	13	to	to	IN
cord-023417-by18aczt	737	14	tumours	tumour	NNS
cord-023417-by18aczt	737	15	of	of	IN
cord-023417-by18aczt	737	16	neuroectodermal	neuroectodermal	JJ
cord-023417-by18aczt	737	17	origin	origin	NN
cord-023417-by18aczt	737	18	.	.	.
cord-023417-by18aczt	738	1	High	high	JJ
cord-023417-by18aczt	738	2	amounts	amount	NNS
cord-023417-by18aczt	738	3	of	of	IN
cord-023417-by18aczt	738	4	nitric	nitric	NN
cord-023417-by18aczt	738	5	oxide	oxide	NN
cord-023417-by18aczt	738	6	(	(	-LRB-
cord-023417-by18aczt	738	7	NO	no	RB
cord-023417-by18aczt	738	8	)	)	-RRB-
cord-023417-by18aczt	738	9	released	release	VBN
cord-023417-by18aczt	738	10	by	by	IN
cord-023417-by18aczt	738	11	activated	activate	VBN
cord-023417-by18aczt	738	12	macrophages	macrophage	NNS
cord-023417-by18aczt	738	13	induce	induce	VBP
cord-023417-by18aczt	738	14	tumour	tumour	NN
cord-023417-by18aczt	738	15	cell	cell	NN
cord-023417-by18aczt	738	16	death	death	NN
cord-023417-by18aczt	738	17	.	.	.
cord-023417-by18aczt	739	1	Therefore	therefore	RB
cord-023417-by18aczt	739	2	,	,	,
cord-023417-by18aczt	739	3	we	-PRON-	PRP
cord-023417-by18aczt	739	4	explored	explore	VBD
cord-023417-by18aczt	739	5	the	the	DT
cord-023417-by18aczt	739	6	capacity	capacity	NN
cord-023417-by18aczt	739	7	of	of	IN
cord-023417-by18aczt	739	8	AE	AE	NNP
cord-023417-by18aczt	739	9	to	to	TO
cord-023417-by18aczt	739	10	modulate	modulate	VB
cord-023417-by18aczt	739	11	NO	no	RB
cord-023417-by18aczt	739	12	-	-	HYPH
cord-023417-by18aczt	739	13	mediated	mediate	VBN
cord-023417-by18aczt	739	14	antitumour	antitumour	JJ
cord-023417-by18aczt	739	15	response	response	NN
cord-023417-by18aczt	739	16	in	in	IN
cord-023417-by18aczt	739	17	vitro	vitro	FW
cord-023417-by18aczt	739	18	.	.	.
cord-023417-by18aczt	740	1	Interestingly	interestingly	RB
cord-023417-by18aczt	740	2	,	,	,
cord-023417-by18aczt	740	3	while	while	IN
cord-023417-by18aczt	740	4	AE	AE	NNP
cord-023417-by18aczt	740	5	markedly	markedly	RB
cord-023417-by18aczt	740	6	suppressed	suppress	VBD
cord-023417-by18aczt	740	7	NO	no	DT
cord-023417-by18aczt	740	8	release	release	NN
cord-023417-by18aczt	740	9	from	from	IN
cord-023417-by18aczt	740	10	macrophages	macrophage	NNS
cord-023417-by18aczt	740	11	alone	alone	RB
cord-023417-by18aczt	740	12	,	,	,
cord-023417-by18aczt	740	13	it	-PRON-	PRP
cord-023417-by18aczt	740	14	significantly	significantly	RB
cord-023417-by18aczt	740	15	potentiated	potentiate	VBD
cord-023417-by18aczt	740	16	NO	no	DT
cord-023417-by18aczt	740	17	production	production	NN
cord-023417-by18aczt	740	18	in	in	IN
cord-023417-by18aczt	740	19	cocultures	coculture	NNS
cord-023417-by18aczt	740	20	of	of	IN
cord-023417-by18aczt	740	21	macrophages	macrophage	NNS
cord-023417-by18aczt	740	22	and	and	CC
cord-023417-by18aczt	740	23	C6	c6	NN
cord-023417-by18aczt	740	24	cells	cell	NNS
cord-023417-by18aczt	740	25	,	,	,
cord-023417-by18aczt	740	26	after	after	IN
cord-023417-by18aczt	740	27	48	48	CD
cord-023417-by18aczt	740	28	h	h	NN
cord-023417-by18aczt	740	29	of	of	IN
cord-023417-by18aczt	740	30	cultivation	cultivation	NN
cord-023417-by18aczt	740	31	.	.	.
cord-023417-by18aczt	741	1	Accordingly	accordingly	RB
cord-023417-by18aczt	741	2	,	,	,
cord-023417-by18aczt	741	3	the	the	DT
cord-023417-by18aczt	741	4	viability	viability	NN
cord-023417-by18aczt	741	5	of	of	IN
cord-023417-by18aczt	741	6	C6	C6	NNP
cord-023417-by18aczt	741	7	cells	cell	NNS
cord-023417-by18aczt	741	8	cocultivated	cocultivate	VBN
cord-023417-by18aczt	741	9	with	with	IN
cord-023417-by18aczt	741	10	macrophages	macrophage	NNS
cord-023417-by18aczt	741	11	was	be	VBD
cord-023417-by18aczt	741	12	reduced	reduce	VBN
cord-023417-by18aczt	741	13	in	in	IN
cord-023417-by18aczt	741	14	the	the	DT
cord-023417-by18aczt	741	15	presence	presence	NN
cord-023417-by18aczt	741	16	of	of	IN
cord-023417-by18aczt	741	17	AE	AE	NNP
cord-023417-by18aczt	741	18	.	.	.
cord-023417-by18aczt	742	1	Moreover	moreover	RB
cord-023417-by18aczt	742	2	,	,	,
cord-023417-by18aczt	742	3	the	the	DT
cord-023417-by18aczt	742	4	observed	observed	JJ
cord-023417-by18aczt	742	5	AE	AE	NNP
cord-023417-by18aczt	742	6	-	-	HYPH
cord-023417-by18aczt	742	7	imposed	impose	VBN
cord-023417-by18aczt	742	8	potentiation	potentiation	NN
cord-023417-by18aczt	742	9	of	of	IN
cord-023417-by18aczt	742	10	NO	no	DT
cord-023417-by18aczt	742	11	production	production	NN
cord-023417-by18aczt	742	12	in	in	IN
cord-023417-by18aczt	742	13	macrophages	macrophage	NNS
cord-023417-by18aczt	742	14	was	be	VBD
cord-023417-by18aczt	742	15	closely	closely	RB
cord-023417-by18aczt	742	16	related	relate	VBN
cord-023417-by18aczt	742	17	to	to	IN
cord-023417-by18aczt	742	18	macrophage	macrophage	NN
cord-023417-by18aczt	742	19	culture	culture	NN
cord-023417-by18aczt	742	20	cell	cell	NN
cord-023417-by18aczt	742	21	density	density	NN
cord-023417-by18aczt	742	22	.	.	.
cord-023417-by18aczt	743	1	According	accord	VBG
cord-023417-by18aczt	743	2	to	to	IN
cord-023417-by18aczt	743	3	these	these	DT
cord-023417-by18aczt	743	4	data	datum	NNS
cord-023417-by18aczt	743	5	,	,	,
cord-023417-by18aczt	743	6	we	-PRON-	PRP
cord-023417-by18aczt	743	7	proposed	propose	VBD
cord-023417-by18aczt	743	8	that	that	IN
cord-023417-by18aczt	743	9	NO	no	DT
cord-023417-by18aczt	743	10	modulator	modulator	NN
cord-023417-by18aczt	743	11	capacity	capacity	NN
cord-023417-by18aczt	743	12	of	of	IN
cord-023417-by18aczt	743	13	AE	AE	NNP
cord-023417-by18aczt	743	14	strongly	strongly	RB
cord-023417-by18aczt	743	15	depended	depend	VBD
cord-023417-by18aczt	743	16	on	on	IN
cord-023417-by18aczt	743	17	intercellular	intercellular	JJ
cord-023417-by18aczt	743	18	contact	contact	NN
cord-023417-by18aczt	743	19	,	,	,
cord-023417-by18aczt	743	20	indicating	indicate	VBG
cord-023417-by18aczt	743	21	that	that	IN
cord-023417-by18aczt	743	22	macrophage	macrophage	NN
cord-023417-by18aczt	743	23	antitumour	antitumour	JJ
cord-023417-by18aczt	743	24	response	response	NN
cord-023417-by18aczt	743	25	was	be	VBD
cord-023417-by18aczt	743	26	not	not	RB
cord-023417-by18aczt	743	27	compromised	compromised	JJ
cord-023417-by18aczt	743	28	but	but	CC
cord-023417-by18aczt	743	29	even	even	RB
cord-023417-by18aczt	743	30	potentiated	potentiate	VBN
cord-023417-by18aczt	743	31	by	by	IN
cord-023417-by18aczt	743	32	AE	AE	NNP
cord-023417-by18aczt	743	33	.	.	.
cord-023417-by18aczt	744	1	Immunotherapy	immunotherapy	NN
cord-023417-by18aczt	744	2	represents	represent	VBZ
cord-023417-by18aczt	744	3	an	an	DT
cord-023417-by18aczt	744	4	attractive	attractive	JJ
cord-023417-by18aczt	744	5	fourth	fourth	JJ
cord-023417-by18aczt	744	6	-	-	HYPH
cord-023417-by18aczt	744	7	modality	modality	NN
cord-023417-by18aczt	744	8	therapeutic	therapeutic	JJ
cord-023417-by18aczt	744	9	approach	approach	NN
cord-023417-by18aczt	744	10	,	,	,
cord-023417-by18aczt	744	11	especially	especially	RB
cord-023417-by18aczt	744	12	in	in	IN
cord-023417-by18aczt	744	13	the	the	DT
cord-023417-by18aczt	744	14	light	light	NN
cord-023417-by18aczt	744	15	of	of	IN
cord-023417-by18aczt	744	16	the	the	DT
cord-023417-by18aczt	744	17	shortcomings	shortcoming	NNS
cord-023417-by18aczt	744	18	of	of	IN
cord-023417-by18aczt	744	19	conventional	conventional	JJ
cord-023417-by18aczt	744	20	surgery	surgery	NN
cord-023417-by18aczt	744	21	,	,	,
cord-023417-by18aczt	744	22	radiation	radiation	NN
cord-023417-by18aczt	744	23	and	and	CC
cord-023417-by18aczt	744	24	chemotherapies	chemotherapy	NNS
cord-023417-by18aczt	744	25	in	in	IN
cord-023417-by18aczt	744	26	the	the	DT
cord-023417-by18aczt	744	27	management	management	NN
cord-023417-by18aczt	744	28	of	of	IN
cord-023417-by18aczt	744	29	metastatic	metastatic	JJ
cord-023417-by18aczt	744	30	cancer	cancer	NN
cord-023417-by18aczt	744	31	.	.	.
cord-023417-by18aczt	745	1	To	to	IN
cord-023417-by18aczt	745	2	this	this	DT
cord-023417-by18aczt	745	3	end	end	NN
cord-023417-by18aczt	745	4	,	,	,
cord-023417-by18aczt	745	5	a	a	DT
cord-023417-by18aczt	745	6	large	large	JJ
cord-023417-by18aczt	745	7	number	number	NN
cord-023417-by18aczt	745	8	of	of	IN
cord-023417-by18aczt	745	9	peptide	peptide	JJ
cord-023417-by18aczt	745	10	antigens	antigen	NNS
cord-023417-by18aczt	745	11	derived	derive	VBN
cord-023417-by18aczt	745	12	from	from	IN
cord-023417-by18aczt	745	13	TAA	TAA	NNP
cord-023417-by18aczt	745	14	have	have	VBP
cord-023417-by18aczt	745	15	been	be	VBN
cord-023417-by18aczt	745	16	applied	apply	VBN
cord-023417-by18aczt	745	17	in	in	IN
cord-023417-by18aczt	745	18	immunotherapeutic	immunotherapeutic	JJ
cord-023417-by18aczt	745	19	trials	trial	NNS
cord-023417-by18aczt	745	20	for	for	IN
cord-023417-by18aczt	745	21	the	the	DT
cord-023417-by18aczt	745	22	treatment	treatment	NN
cord-023417-by18aczt	745	23	of	of	IN
cord-023417-by18aczt	745	24	various	various	JJ
cord-023417-by18aczt	745	25	malignancies	malignancy	NNS
cord-023417-by18aczt	745	26	,	,	,
cord-023417-by18aczt	745	27	e.g.	e.g.	IN
cord-023417-by18aczt	745	28	cancers	cancer	NNS
cord-023417-by18aczt	745	29	of	of	IN
cord-023417-by18aczt	745	30	the	the	DT
cord-023417-by18aczt	745	31	breast	breast	NN
cord-023417-by18aczt	745	32	,	,	,
cord-023417-by18aczt	745	33	prostate	prostate	NN
cord-023417-by18aczt	745	34	and	and	CC
cord-023417-by18aczt	745	35	kidney	kidney	NN
cord-023417-by18aczt	745	36	,	,	,
cord-023417-by18aczt	745	37	in	in	IN
cord-023417-by18aczt	745	38	addition	addition	NN
cord-023417-by18aczt	745	39	to	to	IN
cord-023417-by18aczt	745	40	haematological	haematological	JJ
cord-023417-by18aczt	745	41	cancers	cancer	NNS
cord-023417-by18aczt	745	42	.	.	.
cord-023417-by18aczt	746	1	In	in	IN
cord-023417-by18aczt	746	2	some	some	DT
cord-023417-by18aczt	746	3	cases	case	NNS
cord-023417-by18aczt	746	4	the	the	DT
cord-023417-by18aczt	746	5	response	response	NN
cord-023417-by18aczt	746	6	rates	rate	NNS
cord-023417-by18aczt	746	7	have	have	VBP
cord-023417-by18aczt	746	8	been	be	VBN
cord-023417-by18aczt	746	9	impressive	impressive	JJ
cord-023417-by18aczt	746	10	and	and	CC
cord-023417-by18aczt	746	11	no	no	DT
cord-023417-by18aczt	746	12	adverse	adverse	JJ
cord-023417-by18aczt	746	13	autoimmunity	autoimmunity	NN
cord-023417-by18aczt	746	14	have	have	VBP
cord-023417-by18aczt	746	15	been	be	VBN
cord-023417-by18aczt	746	16	observed	observe	VBN
cord-023417-by18aczt	746	17	.	.	.
cord-023417-by18aczt	747	1	A	a	DT
cord-023417-by18aczt	747	2	major	major	JJ
cord-023417-by18aczt	747	3	strategic	strategic	JJ
cord-023417-by18aczt	747	4	difficulty	difficulty	NN
cord-023417-by18aczt	747	5	associated	associate	VBN
cord-023417-by18aczt	747	6	with	with	IN
cord-023417-by18aczt	747	7	these	these	DT
cord-023417-by18aczt	747	8	trials	trial	NNS
cord-023417-by18aczt	747	9	relates	relate	VBZ
cord-023417-by18aczt	747	10	to	to	IN
cord-023417-by18aczt	747	11	the	the	DT
cord-023417-by18aczt	747	12	choice	choice	NN
cord-023417-by18aczt	747	13	of	of	IN
cord-023417-by18aczt	747	14	best	best	RB
cord-023417-by18aczt	747	15	-	-	HYPH
cord-023417-by18aczt	747	16	suited	suit	VBN
cord-023417-by18aczt	747	17	peptide	peptide	NN
cord-023417-by18aczt	747	18	antigens	antigen	NNS
cord-023417-by18aczt	747	19	.	.	.
cord-023417-by18aczt	748	1	The	the	DT
cord-023417-by18aczt	748	2	vast	vast	JJ
cord-023417-by18aczt	748	3	majority	majority	NN
cord-023417-by18aczt	748	4	of	of	IN
cord-023417-by18aczt	748	5	the	the	DT
cord-023417-by18aczt	748	6	antigens	antigen	NNS
cord-023417-by18aczt	748	7	described	describe	VBN
cord-023417-by18aczt	748	8	thus	thus	RB
cord-023417-by18aczt	748	9	far	far	RB
cord-023417-by18aczt	748	10	is	be	VBZ
cord-023417-by18aczt	748	11	not	not	RB
cord-023417-by18aczt	748	12	vital	vital	JJ
cord-023417-by18aczt	748	13	for	for	IN
cord-023417-by18aczt	748	14	survival	survival	NN
cord-023417-by18aczt	748	15	and	and	CC
cord-023417-by18aczt	748	16	growth	growth	NN
cord-023417-by18aczt	748	17	of	of	IN
cord-023417-by18aczt	748	18	the	the	DT
cord-023417-by18aczt	748	19	tumour	tumour	NN
cord-023417-by18aczt	748	20	cells	cell	NNS
cord-023417-by18aczt	748	21	,	,	,
cord-023417-by18aczt	748	22	and	and	CC
cord-023417-by18aczt	748	23	immunoselection	immunoselection	NN
cord-023417-by18aczt	748	24	of	of	IN
cord-023417-by18aczt	748	25	antigen	antigen	NN
cord-023417-by18aczt	748	26	-	-	HYPH
cord-023417-by18aczt	748	27	loss	loss	NN
cord-023417-by18aczt	748	28	variants	variant	NNS
cord-023417-by18aczt	748	29	may	may	MD
cord-023417-by18aczt	748	30	therefore	therefore	RB
cord-023417-by18aczt	748	31	prove	prove	VB
cord-023417-by18aczt	748	32	to	to	TO
cord-023417-by18aczt	748	33	be	be	VB
cord-023417-by18aczt	748	34	an	an	DT
cord-023417-by18aczt	748	35	additional	additional	JJ
cord-023417-by18aczt	748	36	obstacle	obstacle	NN
cord-023417-by18aczt	748	37	for	for	IN
cord-023417-by18aczt	748	38	the	the	DT
cord-023417-by18aczt	748	39	clinical	clinical	JJ
cord-023417-by18aczt	748	40	applicability	applicability	NN
cord-023417-by18aczt	748	41	of	of	IN
cord-023417-by18aczt	748	42	most	most	JJS
cord-023417-by18aczt	748	43	of	of	IN
cord-023417-by18aczt	748	44	the	the	DT
cord-023417-by18aczt	748	45	known	know	VBN
cord-023417-by18aczt	748	46	peptide	peptide	NN
cord-023417-by18aczt	748	47	epitopes	epitope	NNS
cord-023417-by18aczt	748	48	.	.	.
cord-023417-by18aczt	749	1	In	in	IN
cord-023417-by18aczt	749	2	this	this	DT
cord-023417-by18aczt	749	3	respect	respect	NN
cord-023417-by18aczt	749	4	,	,	,
cord-023417-by18aczt	749	5	the	the	DT
cord-023417-by18aczt	749	6	development	development	NN
cord-023417-by18aczt	749	7	of	of	IN
cord-023417-by18aczt	749	8	acquired	acquire	VBN
cord-023417-by18aczt	749	9	antigen	antigen	NN
cord-023417-by18aczt	749	10	loss	loss	NN
cord-023417-by18aczt	749	11	during	during	IN
cord-023417-by18aczt	749	12	immunotherapy	immunotherapy	NN
cord-023417-by18aczt	749	13	has	have	VBZ
cord-023417-by18aczt	749	14	been	be	VBN
cord-023417-by18aczt	749	15	demonstrated	demonstrate	VBN
cord-023417-by18aczt	749	16	in	in	IN
cord-023417-by18aczt	749	17	several	several	JJ
cord-023417-by18aczt	749	18	cases	case	NNS
cord-023417-by18aczt	749	19	.	.	.
cord-023417-by18aczt	750	1	Obviously	obviously	RB
cord-023417-by18aczt	750	2	,	,	,
cord-023417-by18aczt	750	3	the	the	DT
cord-023417-by18aczt	750	4	development	development	NN
cord-023417-by18aczt	750	5	of	of	IN
cord-023417-by18aczt	750	6	loss	loss	NN
cord-023417-by18aczt	750	7	-	-	HYPH
cord-023417-by18aczt	750	8	variant	variant	NN
cord-023417-by18aczt	750	9	tumour	tumour	NN
cord-023417-by18aczt	750	10	cells	cell	NNS
cord-023417-by18aczt	750	11	implies	imply	VBZ
cord-023417-by18aczt	750	12	that	that	IN
cord-023417-by18aczt	750	13	these	these	DT
cord-023417-by18aczt	750	14	cells	cell	NNS
cord-023417-by18aczt	750	15	acquire	acquire	VBP
cord-023417-by18aczt	750	16	a	a	DT
cord-023417-by18aczt	750	17	pronounced	pronounce	VBN
cord-023417-by18aczt	750	18	growth	growth	NN
cord-023417-by18aczt	750	19	advantage	advantage	NN
cord-023417-by18aczt	750	20	and	and	CC
cord-023417-by18aczt	750	21	are	be	VBP
cord-023417-by18aczt	750	22	left	leave	VBN
cord-023417-by18aczt	750	23	unaffected	unaffected	JJ
cord-023417-by18aczt	750	24	by	by	IN
cord-023417-by18aczt	750	25	further	further	JJ
cord-023417-by18aczt	750	26	treatment	treatment	NN
cord-023417-by18aczt	750	27	.	.	.
cord-023417-by18aczt	751	1	Ideally	ideally	RB
cord-023417-by18aczt	751	2	,	,	,
cord-023417-by18aczt	751	3	target	target	NN
cord-023417-by18aczt	751	4	antigens	antigen	NNS
cord-023417-by18aczt	751	5	should	should	MD
cord-023417-by18aczt	751	6	be	be	VB
cord-023417-by18aczt	751	7	derived	derive	VBN
cord-023417-by18aczt	751	8	from	from	IN
cord-023417-by18aczt	751	9	proteins	protein	NNS
cord-023417-by18aczt	751	10	required	require	VBN
cord-023417-by18aczt	751	11	for	for	IN
cord-023417-by18aczt	751	12	survival	survival	NN
cord-023417-by18aczt	751	13	and	and	CC
cord-023417-by18aczt	751	14	growth	growth	NN
cord-023417-by18aczt	751	15	of	of	IN
cord-023417-by18aczt	751	16	tumour	tumour	NN
cord-023417-by18aczt	751	17	cells	cell	NNS
cord-023417-by18aczt	751	18	,	,	,
cord-023417-by18aczt	751	19	as	as	IN
cord-023417-by18aczt	751	20	antigens	antigen	NNS
cord-023417-by18aczt	751	21	with	with	IN
cord-023417-by18aczt	751	22	these	these	DT
cord-023417-by18aczt	751	23	characteristics	characteristic	NNS
cord-023417-by18aczt	751	24	would	would	MD
cord-023417-by18aczt	751	25	not	not	RB
cord-023417-by18aczt	751	26	be	be	VB
cord-023417-by18aczt	751	27	inflicted	inflict	VBN
cord-023417-by18aczt	751	28	by	by	IN
cord-023417-by18aczt	751	29	the	the	DT
cord-023417-by18aczt	751	30	development	development	NN
cord-023417-by18aczt	751	31	of	of	IN
cord-023417-by18aczt	751	32	loss	loss	NN
cord-023417-by18aczt	751	33	-	-	HYPH
cord-023417-by18aczt	751	34	variant	variant	NN
cord-023417-by18aczt	751	35	tumour	tumour	NN
cord-023417-by18aczt	751	36	cells	cell	NNS
cord-023417-by18aczt	751	37	.	.	.
cord-023417-by18aczt	752	1	In	in	IN
cord-023417-by18aczt	752	2	this	this	DT
cord-023417-by18aczt	752	3	respect	respect	NN
cord-023417-by18aczt	752	4	,	,	,
cord-023417-by18aczt	752	5	several	several	JJ
cord-023417-by18aczt	752	6	inhibitors	inhibitor	NNS
cord-023417-by18aczt	752	7	of	of	IN
cord-023417-by18aczt	752	8	apoptosis	apoptosis	NN
cord-023417-by18aczt	752	9	proteins	protein	NNS
cord-023417-by18aczt	752	10	(	(	-LRB-
cord-023417-by18aczt	752	11	IAPs	IAPs	NNP
cord-023417-by18aczt	752	12	)	)	-RRB-
cord-023417-by18aczt	752	13	are	be	VBP
cord-023417-by18aczt	752	14	universally	universally	RB
cord-023417-by18aczt	752	15	expressed	express	VBN
cord-023417-by18aczt	752	16	among	among	IN
cord-023417-by18aczt	752	17	tumours	tumour	NNS
cord-023417-by18aczt	752	18	and	and	CC
cord-023417-by18aczt	752	19	play	play	VB
cord-023417-by18aczt	752	20	an	an	DT
cord-023417-by18aczt	752	21	important	important	JJ
cord-023417-by18aczt	752	22	role	role	NN
cord-023417-by18aczt	752	23	in	in	IN
cord-023417-by18aczt	752	24	tumour	tumour	NN
cord-023417-by18aczt	752	25	cell	cell	NN
cord-023417-by18aczt	752	26	escape	escape	NN
cord-023417-by18aczt	752	27	from	from	IN
cord-023417-by18aczt	752	28	apoptosis	apoptosis	NN
cord-023417-by18aczt	752	29	.	.	.
cord-023417-by18aczt	753	1	We	-PRON-	PRP
cord-023417-by18aczt	753	2	have	have	VBP
cord-023417-by18aczt	753	3	characterized	characterize	VBN
cord-023417-by18aczt	753	4	spontaneous	spontaneous	JJ
cord-023417-by18aczt	753	5	T	t	NN
cord-023417-by18aczt	753	6	-	-	HYPH
cord-023417-by18aczt	753	7	cell	cell	NN
cord-023417-by18aczt	753	8	reactivity	reactivity	NN
cord-023417-by18aczt	753	9	against	against	IN
cord-023417-by18aczt	753	10	IAPderived	iapderived	JJ
cord-023417-by18aczt	753	11	peptides	peptide	NNS
cord-023417-by18aczt	753	12	in	in	IN
cord-023417-by18aczt	753	13	cancer	cancer	NN
cord-023417-by18aczt	753	14	patients	patient	NNS
cord-023417-by18aczt	753	15	.	.	.
cord-023417-by18aczt	754	1	From	from	IN
cord-023417-by18aczt	754	2	the	the	DT
cord-023417-by18aczt	754	3	IAP	IAP	NNP
cord-023417-by18aczt	754	4	survivin	survivin	NN
cord-023417-by18aczt	754	5	,	,	,
cord-023417-by18aczt	754	6	we	-PRON-	PRP
cord-023417-by18aczt	754	7	have	have	VBP
cord-023417-by18aczt	754	8	characterized	characterize	VBN
cord-023417-by18aczt	754	9	peptides	peptide	NNS
cord-023417-by18aczt	754	10	restricted	restrict	VBN
cord-023417-by18aczt	754	11	to	to	IN
cord-023417-by18aczt	754	12	the	the	DT
cord-023417-by18aczt	754	13	Class	class	NN
cord-023417-by18aczt	755	1	I	-PRON-	PRP
cord-023417-by18aczt	755	2	molecules	molecule	VBZ
cord-023417-by18aczt	755	3	HLA	HLA	NNP
cord-023417-by18aczt	755	4	-	-	HYPH
cord-023417-by18aczt	755	5	A1	A1	NNP
cord-023417-by18aczt	755	6	,	,	,
cord-023417-by18aczt	755	7	A2	A2	NNP
cord-023417-by18aczt	755	8	,	,	,
cord-023417-by18aczt	755	9	A3	A3	NNP
cord-023417-by18aczt	755	10	,	,	,
cord-023417-by18aczt	755	11	A11	A11	NNP
cord-023417-by18aczt	755	12	,	,	,
cord-023417-by18aczt	755	13	B7	b7	NN
cord-023417-by18aczt	755	14	and	and	CC
cord-023417-by18aczt	755	15	B35	B35	NNP
cord-023417-by18aczt	755	16	.	.	.
cord-023417-by18aczt	756	1	Furthermore	furthermore	RB
cord-023417-by18aczt	756	2	,	,	,
cord-023417-by18aczt	756	3	we	-PRON-	PRP
cord-023417-by18aczt	756	4	have	have	VBP
cord-023417-by18aczt	756	5	demonstrated	demonstrate	VBN
cord-023417-by18aczt	756	6	that	that	IN
cord-023417-by18aczt	756	7	survivin	survivin	NN
cord-023417-by18aczt	756	8	-	-	HYPH
cord-023417-by18aczt	756	9	specific	specific	JJ
cord-023417-by18aczt	756	10	T	t	NN
cord-023417-by18aczt	756	11	cells	cell	NNS
cord-023417-by18aczt	756	12	infiltrate	infiltrate	VBP
cord-023417-by18aczt	756	13	metastatic	metastatic	JJ
cord-023417-by18aczt	756	14	lesions	lesion	NNS
cord-023417-by18aczt	756	15	and	and	CC
cord-023417-by18aczt	756	16	that	that	IN
cord-023417-by18aczt	756	17	isolated	isolate	VBN
cord-023417-by18aczt	756	18	survivinspecific	survivinspecific	NN
cord-023417-by18aczt	756	19	CTLs	ctl	NNS
cord-023417-by18aczt	756	20	are	be	VBP
cord-023417-by18aczt	756	21	capable	capable	JJ
cord-023417-by18aczt	756	22	of	of	IN
cord-023417-by18aczt	756	23	killing	kill	VBG
cord-023417-by18aczt	756	24	HLA	HLA	NNP
cord-023417-by18aczt	756	25	-	-	HYPH
cord-023417-by18aczt	756	26	matched	match	VBN
cord-023417-by18aczt	756	27	tumour	tumour	NN
cord-023417-by18aczt	756	28	cells	cell	NNS
cord-023417-by18aczt	756	29	.	.	.
cord-023417-by18aczt	757	1	Survivin	Survivin	NNP
cord-023417-by18aczt	757	2	-	-	HYPH
cord-023417-by18aczt	757	3	derived	derive	VBN
cord-023417-by18aczt	757	4	peptides	peptide	NNS
cord-023417-by18aczt	757	5	are	be	VBP
cord-023417-by18aczt	757	6	now	now	RB
cord-023417-by18aczt	757	7	in	in	IN
cord-023417-by18aczt	757	8	clinical	clinical	JJ
cord-023417-by18aczt	757	9	trial	trial	NN
cord-023417-by18aczt	757	10	,	,	,
cord-023417-by18aczt	757	11	and	and	CC
cord-023417-by18aczt	757	12	continued	continue	VBD
cord-023417-by18aczt	757	13	work	work	NN
cord-023417-by18aczt	757	14	in	in	IN
cord-023417-by18aczt	757	15	our	-PRON-	PRP$
cord-023417-by18aczt	757	16	lab	lab	NN
cord-023417-by18aczt	757	17	has	have	VBZ
cord-023417-by18aczt	757	18	demonstrated	demonstrate	VBN
cord-023417-by18aczt	757	19	that	that	IN
cord-023417-by18aczt	757	20	other	other	JJ
cord-023417-by18aczt	757	21	IAPs	iap	NNS
cord-023417-by18aczt	757	22	are	be	VBP
cord-023417-by18aczt	757	23	targets	target	NNS
cord-023417-by18aczt	757	24	for	for	IN
cord-023417-by18aczt	757	25	spontaneous	spontaneous	JJ
cord-023417-by18aczt	757	26	T	t	NN
cord-023417-by18aczt	757	27	-	-	HYPH
cord-023417-by18aczt	757	28	cell	cell	NN
cord-023417-by18aczt	757	29	reactivity	reactivity	NN
cord-023417-by18aczt	757	30	in	in	IN
cord-023417-by18aczt	757	31	cancer	cancer	NN
cord-023417-by18aczt	757	32	patients	patient	NNS
cord-023417-by18aczt	757	33	.	.	.
cord-023417-by18aczt	758	1	We	-PRON-	PRP
cord-023417-by18aczt	758	2	previously	previously	RB
cord-023417-by18aczt	758	3	reported	report	VBD
cord-023417-by18aczt	758	4	that	that	IN
cord-023417-by18aczt	758	5	in	in	IN
cord-023417-by18aczt	758	6	mice	mouse	NNS
cord-023417-by18aczt	758	7	with	with	IN
cord-023417-by18aczt	758	8	large	large	JJ
cord-023417-by18aczt	758	9	progressing	progress	VBG
cord-023417-by18aczt	758	10	T	t	NN
cord-023417-by18aczt	758	11	-	-	HYPH
cord-023417-by18aczt	758	12	cell	cell	NN
cord-023417-by18aczt	758	13	lymphoma	lymphoma	NN
cord-023417-by18aczt	758	14	tumours	tumour	NNS
cord-023417-by18aczt	758	15	,	,	,
cord-023417-by18aczt	758	16	dysfunctions	dysfunction	NNS
cord-023417-by18aczt	758	17	in	in	IN
cord-023417-by18aczt	758	18	the	the	DT
cord-023417-by18aczt	758	19	antitumour	antitumour	JJ
cord-023417-by18aczt	758	20	CTL	CTL	NNP
cord-023417-by18aczt	758	21	activity	activity	NN
cord-023417-by18aczt	758	22	occur	occur	VBP
cord-023417-by18aczt	758	23	,	,	,
cord-023417-by18aczt	758	24	associated	associate	VBN
cord-023417-by18aczt	758	25	with	with	IN
cord-023417-by18aczt	758	26	an	an	DT
cord-023417-by18aczt	758	27	accumulation	accumulation	NN
cord-023417-by18aczt	758	28	of	of	IN
cord-023417-by18aczt	758	29	splenic	splenic	JJ
cord-023417-by18aczt	758	30	arginase	arginase	NN
cord-023417-by18aczt	758	31	-	-	HYPH
cord-023417-by18aczt	758	32	producing	produce	VBG
cord-023417-by18aczt	758	33	myeloid	myeloid	NN
cord-023417-by18aczt	758	34	suppressor	suppressor	NN
cord-023417-by18aczt	758	35	cells	cell	NNS
cord-023417-by18aczt	758	36	(	(	-LRB-
cord-023417-by18aczt	758	37	MSCs	msc	NNS
cord-023417-by18aczt	758	38	)	)	-RRB-
cord-023417-by18aczt	758	39	.	.	.
cord-023417-by18aczt	759	1	In	in	IN
cord-023417-by18aczt	759	2	this	this	DT
cord-023417-by18aczt	759	3	study	study	NN
cord-023417-by18aczt	759	4	,	,	,
cord-023417-by18aczt	759	5	we	-PRON-	PRP
cord-023417-by18aczt	759	6	first	first	RB
cord-023417-by18aczt	759	7	demonstrate	demonstrate	VBP
cord-023417-by18aczt	759	8	that	that	IN
cord-023417-by18aczt	759	9	both	both	CC
cord-023417-by18aczt	759	10	the	the	DT
cord-023417-by18aczt	759	11	presence	presence	NN
cord-023417-by18aczt	759	12	and	and	CC
cord-023417-by18aczt	759	13	the	the	DT
cord-023417-by18aczt	759	14	activation	activation	NN
cord-023417-by18aczt	759	15	state	state	NN
cord-023417-by18aczt	759	16	of	of	IN
cord-023417-by18aczt	759	17	these	these	DT
cord-023417-by18aczt	759	18	MSC	MSC	NNP
cord-023417-by18aczt	759	19	depends	depend	VBZ
cord-023417-by18aczt	759	20	on	on	IN
cord-023417-by18aczt	759	21	tumour	tumour	NN
cord-023417-by18aczt	759	22	evolution	evolution	NN
cord-023417-by18aczt	759	23	.	.	.
cord-023417-by18aczt	760	1	While	while	IN
cord-023417-by18aczt	760	2	in	in	IN
cord-023417-by18aczt	760	3	tumour	tumour	NN
cord-023417-by18aczt	760	4	regressors	regressor	NNS
cord-023417-by18aczt	760	5	hardly	hardly	RB
cord-023417-by18aczt	760	6	any	any	DT
cord-023417-by18aczt	760	7	arginase	arginase	NN
cord-023417-by18aczt	760	8	-	-	HYPH
cord-023417-by18aczt	760	9	producing	produce	VBG
cord-023417-by18aczt	760	10	MSC	MSC	NNP
cord-023417-by18aczt	760	11	can	can	MD
cord-023417-by18aczt	760	12	be	be	VB
cord-023417-by18aczt	760	13	found	find	VBN
cord-023417-by18aczt	760	14	,	,	,
cord-023417-by18aczt	760	15	both	both	CC
cord-023417-by18aczt	760	16	the	the	DT
cord-023417-by18aczt	760	17	amount	amount	NN
cord-023417-by18aczt	760	18	and	and	CC
cord-023417-by18aczt	760	19	the	the	DT
cord-023417-by18aczt	760	20	arginase	arginase	NN
cord-023417-by18aczt	760	21	activity	activity	NN
cord-023417-by18aczt	760	22	of	of	IN
cord-023417-by18aczt	760	23	this	this	DT
cord-023417-by18aczt	760	24	population	population	NN
cord-023417-by18aczt	760	25	expands	expand	VBZ
cord-023417-by18aczt	760	26	from	from	IN
cord-023417-by18aczt	760	27	early	early	RB
cord-023417-by18aczt	760	28	over	over	IN
cord-023417-by18aczt	760	29	late	late	JJ
cord-023417-by18aczt	760	30	progressors	progressor	NNS
cord-023417-by18aczt	760	31	.	.	.
cord-023417-by18aczt	761	1	This	this	DT
cord-023417-by18aczt	761	2	gradual	gradual	JJ
cord-023417-by18aczt	761	3	induction	induction	NN
cord-023417-by18aczt	761	4	of	of	IN
cord-023417-by18aczt	761	5	MSCs	mscs	NN
cord-023417-by18aczt	761	6	is	be	VBZ
cord-023417-by18aczt	761	7	paralleled	parallel	VBN
cord-023417-by18aczt	761	8	by	by	IN
cord-023417-by18aczt	761	9	an	an	DT
cord-023417-by18aczt	761	10	increasing	increase	VBG
cord-023417-by18aczt	761	11	suppression	suppression	NN
cord-023417-by18aczt	761	12	of	of	IN
cord-023417-by18aczt	761	13	CTL	CTL	NNP
cord-023417-by18aczt	761	14	activity	activity	NN
cord-023417-by18aczt	761	15	and	and	CC
cord-023417-by18aczt	761	16	Th1	th1	NN
cord-023417-by18aczt	761	17	,	,	,
cord-023417-by18aczt	761	18	but	but	CC
cord-023417-by18aczt	761	19	not	not	RB
cord-023417-by18aczt	761	20	Th2	th2	CD
cord-023417-by18aczt	761	21	,	,	,
cord-023417-by18aczt	761	22	cytokine	cytokine	JJ
cord-023417-by18aczt	761	23	production	production	NN
cord-023417-by18aczt	761	24	.	.	.
cord-023417-by18aczt	762	1	Upon	upon	IN
cord-023417-by18aczt	762	2	analysing	analyse	VBG
cord-023417-by18aczt	762	3	the	the	DT
cord-023417-by18aczt	762	4	molecular	molecular	JJ
cord-023417-by18aczt	762	5	repertoire	repertoire	NN
cord-023417-by18aczt	762	6	of	of	IN
cord-023417-by18aczt	762	7	MSC	MSC	NNP
cord-023417-by18aczt	762	8	in	in	IN
cord-023417-by18aczt	762	9	vitro	vitro	FW
cord-023417-by18aczt	762	10	,	,	,
cord-023417-by18aczt	762	11	we	-PRON-	PRP
cord-023417-by18aczt	762	12	found	find	VBD
cord-023417-by18aczt	762	13	,	,	,
cord-023417-by18aczt	762	14	besides	besides	IN
cord-023417-by18aczt	762	15	arginase1	arginase1	NN
cord-023417-by18aczt	762	16	,	,	,
cord-023417-by18aczt	762	17	a	a	DT
cord-023417-by18aczt	762	18	well	well	RB
cord-023417-by18aczt	762	19	-	-	HYPH
cord-023417-by18aczt	762	20	established	establish	VBN
cord-023417-by18aczt	762	21	marker	marker	NN
cord-023417-by18aczt	762	22	for	for	IN
cord-023417-by18aczt	762	23	alternatively	alternatively	RB
cord-023417-by18aczt	762	24	activated	activate	VBN
cord-023417-by18aczt	762	25	myeloid	myeloid	NN
cord-023417-by18aczt	762	26	cells	cell	NNS
cord-023417-by18aczt	762	27	or	or	CC
cord-023417-by18aczt	762	28	M2	M2	NNP
cord-023417-by18aczt	762	29	,	,	,
cord-023417-by18aczt	762	30	a	a	DT
cord-023417-by18aczt	762	31	strong	strong	JJ
cord-023417-by18aczt	762	32	upregulation	upregulation	NN
cord-023417-by18aczt	762	33	of	of	IN
cord-023417-by18aczt	762	34	FIZZ1	FIZZ1	NNP
cord-023417-by18aczt	762	35	and	and	CC
cord-023417-by18aczt	762	36	Ym	Ym	NNP
cord-023417-by18aczt	762	37	,	,	,
cord-023417-by18aczt	762	38	two	two	CD
cord-023417-by18aczt	762	39	additional	additional	JJ
cord-023417-by18aczt	762	40	recently	recently	RB
cord-023417-by18aczt	762	41	identified	identify	VBN
cord-023417-by18aczt	762	42	markers	marker	NNS
cord-023417-by18aczt	762	43	for	for	IN
cord-023417-by18aczt	762	44	M2	M2	NNP
cord-023417-by18aczt	762	45	.	.	.
cord-023417-by18aczt	763	1	Further	further	JJ
cord-023417-by18aczt	763	2	evaluation	evaluation	NN
cord-023417-by18aczt	763	3	of	of	IN
cord-023417-by18aczt	763	4	molecular	molecular	JJ
cord-023417-by18aczt	763	5	markers	marker	NNS
cord-023417-by18aczt	763	6	by	by	IN
cord-023417-by18aczt	763	7	microarray	microarray	NN
cord-023417-by18aczt	763	8	analysis	analysis	NN
cord-023417-by18aczt	763	9	in	in	IN
cord-023417-by18aczt	763	10	MSC	MSC	NNP
cord-023417-by18aczt	763	11	yielded	yield	VBD
cord-023417-by18aczt	763	12	genes	gene	NNS
cord-023417-by18aczt	763	13	involved	involve	VBN
cord-023417-by18aczt	763	14	in	in	IN
cord-023417-by18aczt	763	15	wound	wound	JJ
cord-023417-by18aczt	763	16	healing	healing	NN
cord-023417-by18aczt	763	17	(	(	-LRB-
cord-023417-by18aczt	763	18	e.g.	e.g.	JJ
cord-023417-by18aczt	763	19	coagulation	coagulation	NN
cord-023417-by18aczt	763	20	factor	factor	NN
cord-023417-by18aczt	763	21	XIIIa	XIIIa	NNPS
cord-023417-by18aczt	763	22	)	)	-RRB-
cord-023417-by18aczt	763	23	,	,	,
cord-023417-by18aczt	763	24	anti	anti	JJ
cord-023417-by18aczt	763	25	-	-	JJ
cord-023417-by18aczt	763	26	inflammation	inflammation	NN
cord-023417-by18aczt	763	27	(	(	-LRB-
cord-023417-by18aczt	763	28	e.g.	e.g.	RB
cord-023417-by18aczt	763	29	selenoprotein	selenoprotein	NNP
cord-023417-by18aczt	763	30	P	P	NNP
cord-023417-by18aczt	763	31	)	)	-RRB-
cord-023417-by18aczt	763	32	,	,	,
cord-023417-by18aczt	763	33	immunomodulation	immunomodulation	NNP
cord-023417-by18aczt	763	34	(	(	-LRB-
cord-023417-by18aczt	763	35	e.g.	e.g.	RB
cord-023417-by18aczt	763	36	PD	PD	NNP
cord-023417-by18aczt	763	37	-	-	HYPH
cord-023417-by18aczt	763	38	L2	L2	NNP
cord-023417-by18aczt	763	39	)	)	-RRB-
cord-023417-by18aczt	763	40	and	and	CC
cord-023417-by18aczt	763	41	fat	fat	NN
cord-023417-by18aczt	763	42	and	and	CC
cord-023417-by18aczt	763	43	sugar	sugar	NN
cord-023417-by18aczt	763	44	metabolism	metabolism	NN
cord-023417-by18aczt	763	45	(	(	-LRB-
cord-023417-by18aczt	763	46	e.g.	e.g.	IN
cord-023417-by18aczt	763	47	leptin	leptin	NN
cord-023417-by18aczt	763	48	receptor	receptor	NN
cord-023417-by18aczt	763	49	)	)	-RRB-
cord-023417-by18aczt	763	50	.	.	.
cord-023417-by18aczt	764	1	Of	of	IN
cord-023417-by18aczt	764	2	note	note	NN
cord-023417-by18aczt	764	3	,	,	,
cord-023417-by18aczt	764	4	many	many	JJ
cord-023417-by18aczt	764	5	of	of	IN
cord-023417-by18aczt	764	6	these	these	DT
cord-023417-by18aczt	764	7	genes	gene	NNS
cord-023417-by18aczt	764	8	are	be	VBP
cord-023417-by18aczt	764	9	regulated	regulate	VBN
cord-023417-by18aczt	764	10	by	by	IN
cord-023417-by18aczt	764	11	type	type	NN
cord-023417-by18aczt	764	12	2	2	CD
cord-023417-by18aczt	764	13	cytokines	cytokine	NNS
cord-023417-by18aczt	764	14	(	(	-LRB-
cord-023417-by18aczt	764	15	IL-4	IL-4	NNP
cord-023417-by18aczt	764	16	,	,	,
cord-023417-by18aczt	764	17	IL-13	IL-13	NNP
cord-023417-by18aczt	764	18	and	and	CC
cord-023417-by18aczt	764	19	IL-10	IL-10	NNP
cord-023417-by18aczt	764	20	)	)	-RRB-
cord-023417-by18aczt	764	21	and	and	CC
cord-023417-by18aczt	764	22	are	be	VBP
cord-023417-by18aczt	764	23	therefore	therefore	RB
cord-023417-by18aczt	764	24	rather	rather	RB
cord-023417-by18aczt	764	25	M2	M2	NNP
cord-023417-by18aczt	764	26	associated	associate	VBN
cord-023417-by18aczt	764	27	.	.	.
cord-023417-by18aczt	765	1	Overall	overall	RB
cord-023417-by18aczt	765	2	,	,	,
cord-023417-by18aczt	765	3	our	-PRON-	PRP$
cord-023417-by18aczt	765	4	data	datum	NNS
cord-023417-by18aczt	765	5	provide	provide	VBP
cord-023417-by18aczt	765	6	new	new	JJ
cord-023417-by18aczt	765	7	markers	marker	NNS
cord-023417-by18aczt	765	8	for	for	IN
cord-023417-by18aczt	765	9	MSC	MSC	NNP
cord-023417-by18aczt	765	10	in	in	IN
cord-023417-by18aczt	765	11	cancer	cancer	NN
cord-023417-by18aczt	765	12	and	and	CC
cord-023417-by18aczt	765	13	further	further	RB
cord-023417-by18aczt	765	14	establish	establish	VB
cord-023417-by18aczt	765	15	their	-PRON-	PRP$
cord-023417-by18aczt	765	16	M2	M2	NNP
cord-023417-by18aczt	765	17	activation	activation	NN
cord-023417-by18aczt	765	18	state	state	NN
cord-023417-by18aczt	765	19	.	.	.
cord-023417-by18aczt	766	1	study	study	NN
cord-023417-by18aczt	766	2	.	.	.
cord-023417-by18aczt	767	1	Only	only	RB
cord-023417-by18aczt	767	2	SP	SP	NNP
cord-023417-by18aczt	767	3	-	-	HYPH
cord-023417-by18aczt	767	4	A	A	NNP
cord-023417-by18aczt	767	5	showed	show	VBD
cord-023417-by18aczt	767	6	a	a	DT
cord-023417-by18aczt	767	7	significant	significant	JJ
cord-023417-by18aczt	767	8	expression	expression	NN
cord-023417-by18aczt	767	9	in	in	IN
cord-023417-by18aczt	767	10	normal	normal	JJ
cord-023417-by18aczt	767	11	mucosa	mucosa	NN
cord-023417-by18aczt	767	12	which	which	WDT
cord-023417-by18aczt	767	13	was	be	VBD
cord-023417-by18aczt	767	14	downregulated	downregulate	VBN
cord-023417-by18aczt	767	15	in	in	IN
cord-023417-by18aczt	767	16	CRC	CRC	NNP
cord-023417-by18aczt	767	17	.	.	.
cord-023417-by18aczt	768	1	As	as	IN
cord-023417-by18aczt	768	2	the	the	DT
cord-023417-by18aczt	768	3	absolute	absolute	JJ
cord-023417-by18aczt	768	4	signal	signal	JJ
cord-023417-by18aczt	768	5	level	level	NN
cord-023417-by18aczt	768	6	was	be	VBD
cord-023417-by18aczt	768	7	below	below	IN
cord-023417-by18aczt	768	8	the	the	DT
cord-023417-by18aczt	768	9	noise	noise	NN
cord-023417-by18aczt	768	10	threshold	threshold	NN
cord-023417-by18aczt	768	11	,	,	,
cord-023417-by18aczt	768	12	these	these	DT
cord-023417-by18aczt	768	13	results	result	NNS
cord-023417-by18aczt	768	14	have	have	VBP
cord-023417-by18aczt	768	15	to	to	TO
cord-023417-by18aczt	768	16	be	be	VB
cord-023417-by18aczt	768	17	interpreted	interpret	VBN
cord-023417-by18aczt	768	18	with	with	IN
cord-023417-by18aczt	768	19	caution	caution	NN
cord-023417-by18aczt	768	20	and	and	CC
cord-023417-by18aczt	768	21	require	require	VB
cord-023417-by18aczt	768	22	confirmation	confirmation	NN
cord-023417-by18aczt	768	23	by	by	IN
cord-023417-by18aczt	768	24	direct	direct	NNP
cord-023417-by18aczt	768	25	measurenment	measurenment	NNP
cord-023417-by18aczt	768	26	of	of	IN
cord-023417-by18aczt	768	27	the	the	DT
cord-023417-by18aczt	768	28	proteins	protein	NNS
cord-023417-by18aczt	768	29	.	.	.
cord-023417-by18aczt	769	1	Our	-PRON-	PRP$
cord-023417-by18aczt	769	2	results	result	NNS
cord-023417-by18aczt	769	3	suggest	suggest	VBP
cord-023417-by18aczt	769	4	that	that	IN
cord-023417-by18aczt	769	5	there	there	EX
cord-023417-by18aczt	769	6	is	be	VBZ
cord-023417-by18aczt	769	7	no	no	DT
cord-023417-by18aczt	769	8	major	major	JJ
cord-023417-by18aczt	769	9	role	role	NN
cord-023417-by18aczt	769	10	for	for	IN
cord-023417-by18aczt	769	11	the	the	DT
cord-023417-by18aczt	769	12	human	human	JJ
cord-023417-by18aczt	769	13	collectins	collectin	NNS
cord-023417-by18aczt	769	14	in	in	IN
cord-023417-by18aczt	769	15	colorectal	colorectal	JJ
cord-023417-by18aczt	769	16	cancer	cancer	NN
cord-023417-by18aczt	769	17	.	.	.
cord-023417-by18aczt	769	18	 	 	_SP
cord-023417-by18aczt	770	1	Tetramerization	Tetramerization	NNP
cord-023417-by18aczt	770	2	is	be	VBZ
cord-023417-by18aczt	770	3	visualized	visualize	VBN
cord-023417-by18aczt	770	4	by	by	IN
cord-023417-by18aczt	770	5	SDS	SDS	NNP
cord-023417-by18aczt	770	6	-	-	HYPH
cord-023417-by18aczt	770	7	PAGE	PAGE	NNP
cord-023417-by18aczt	770	8	.	.	.
cord-023417-by18aczt	771	1	Conclusion	conclusion	NN
cord-023417-by18aczt	771	2	:	:	:
cord-023417-by18aczt	772	1	An	an	DT
cord-023417-by18aczt	772	2	effective	effective	JJ
cord-023417-by18aczt	772	3	method	method	NN
cord-023417-by18aczt	772	4	for	for	IN
cord-023417-by18aczt	772	5	the	the	DT
cord-023417-by18aczt	772	6	production	production	NN
cord-023417-by18aczt	772	7	of	of	IN
cord-023417-by18aczt	772	8	highly	highly	RB
cord-023417-by18aczt	772	9	pure	pure	JJ
cord-023417-by18aczt	772	10	MHC	MHC	NNP
cord-023417-by18aczt	773	1	I	-PRON-	PRP
cord-023417-by18aczt	773	2	molecules	molecule	NNS
cord-023417-by18aczt	773	3	has	have	VBZ
cord-023417-by18aczt	773	4	been	be	VBN
cord-023417-by18aczt	773	5	applied	apply	VBN
cord-023417-by18aczt	773	6	to	to	IN
cord-023417-by18aczt	773	7	HLA	HLA	NNP
cord-023417-by18aczt	773	8	-	-	HYPH
cord-023417-by18aczt	773	9	B*1501	B*1501	NNP
cord-023417-by18aczt	773	10	and	and	CC
cord-023417-by18aczt	773	11	HLA	HLA	NNP
cord-023417-by18aczt	773	12	-	-	HYPH
cord-023417-by18aczt	773	13	B*5801	B*5801	NNP
cord-023417-by18aczt	773	14	,	,	,
cord-023417-by18aczt	773	15	and	and	CC
cord-023417-by18aczt	773	16	RIA	RIA	NNP
cord-023417-by18aczt	773	17	and	and	CC
cord-023417-by18aczt	773	18	ELISA	ELISA	NNP
cord-023417-by18aczt	773	19	binding	bind	VBG
cord-023417-by18aczt	773	20	assays	assay	NNS
cord-023417-by18aczt	773	21	for	for	IN
cord-023417-by18aczt	773	22	those	those	DT
cord-023417-by18aczt	773	23	alleles	allele	NNS
cord-023417-by18aczt	773	24	have	have	VBP
cord-023417-by18aczt	773	25	been	be	VBN
cord-023417-by18aczt	773	26	established	establish	VBN
cord-023417-by18aczt	773	27	Background	background	NN
cord-023417-by18aczt	773	28	:	:	:
cord-023417-by18aczt	773	29	Proliferation	proliferation	NN
cord-023417-by18aczt	773	30	,	,	,
cord-023417-by18aczt	773	31	differentiation	differentiation	NN
cord-023417-by18aczt	773	32	and	and	CC
cord-023417-by18aczt	773	33	apoptosis	apoptosis	NN
cord-023417-by18aczt	773	34	are	be	VBP
cord-023417-by18aczt	773	35	essential	essential	JJ
cord-023417-by18aczt	773	36	processes	process	NNS
cord-023417-by18aczt	773	37	in	in	IN
cord-023417-by18aczt	773	38	the	the	DT
cord-023417-by18aczt	773	39	normal	normal	JJ
cord-023417-by18aczt	773	40	functions	function	NNS
cord-023417-by18aczt	773	41	of	of	IN
cord-023417-by18aczt	773	42	the	the	DT
cord-023417-by18aczt	773	43	mammary	mammary	JJ
cord-023417-by18aczt	773	44	epithelium	epithelium	NN
cord-023417-by18aczt	773	45	.	.	.
cord-023417-by18aczt	774	1	The	the	DT
cord-023417-by18aczt	774	2	hypothesis	hypothesis	NN
cord-023417-by18aczt	774	3	examined	examine	VBD
cord-023417-by18aczt	774	4	in	in	IN
cord-023417-by18aczt	774	5	this	this	DT
cord-023417-by18aczt	774	6	study	study	NN
cord-023417-by18aczt	774	7	is	be	VBZ
cord-023417-by18aczt	774	8	that	that	IN
cord-023417-by18aczt	774	9	the	the	DT
cord-023417-by18aczt	774	10	transcription	transcription	NN
cord-023417-by18aczt	774	11	factor	factor	NN
cord-023417-by18aczt	774	12	BCL-6	BCL-6	NNP
cord-023417-by18aczt	774	13	is	be	VBZ
cord-023417-by18aczt	774	14	critically	critically	RB
cord-023417-by18aczt	774	15	important	important	JJ
cord-023417-by18aczt	774	16	not	not	RB
cord-023417-by18aczt	774	17	only	only	RB
cord-023417-by18aczt	774	18	for	for	IN
cord-023417-by18aczt	774	19	regulating	regulate	VBG
cord-023417-by18aczt	774	20	B	b	NN
cord-023417-by18aczt	774	21	-	-	HYPH
cord-023417-by18aczt	774	22	cell	cell	NN
cord-023417-by18aczt	774	23	growth	growth	NN
cord-023417-by18aczt	774	24	and	and	CC
cord-023417-by18aczt	774	25	development	development	NN
cord-023417-by18aczt	774	26	but	but	CC
cord-023417-by18aczt	774	27	also	also	RB
cord-023417-by18aczt	774	28	for	for	IN
cord-023417-by18aczt	774	29	mammary	mammary	JJ
cord-023417-by18aczt	774	30	epithelial	epithelial	JJ
cord-023417-by18aczt	774	31	apoptosis	apoptosis	NN
cord-023417-by18aczt	774	32	.	.	.
cord-023417-by18aczt	775	1	Methodology	methodology	NN
cord-023417-by18aczt	775	2	:	:	:
cord-023417-by18aczt	776	1	Twenty	twenty	CD
cord-023417-by18aczt	776	2	breast	breast	NN
cord-023417-by18aczt	776	3	cancer	cancer	NN
cord-023417-by18aczt	776	4	cases	case	NNS
cord-023417-by18aczt	776	5	and	and	CC
cord-023417-by18aczt	776	6	31	31	CD
cord-023417-by18aczt	776	7	healthy	healthy	JJ
cord-023417-by18aczt	776	8	controls	control	NNS
cord-023417-by18aczt	776	9	were	be	VBD
cord-023417-by18aczt	776	10	used	use	VBN
cord-023417-by18aczt	776	11	to	to	TO
cord-023417-by18aczt	776	12	investigate	investigate	VB
cord-023417-by18aczt	776	13	whether	whether	IN
cord-023417-by18aczt	776	14	BCL-6	BCL-6	NNP
cord-023417-by18aczt	776	15	protein	protein	NN
cord-023417-by18aczt	776	16	in	in	IN
cord-023417-by18aczt	776	17	involved	involve	VBN
cord-023417-by18aczt	776	18	in	in	IN
cord-023417-by18aczt	776	19	breast	breast	NN
cord-023417-by18aczt	776	20	cancer	cancer	NN
cord-023417-by18aczt	776	21	(	(	-LRB-
cord-023417-by18aczt	776	22	grade	grade	NN
cord-023417-by18aczt	776	23	III	III	NNP
cord-023417-by18aczt	776	24	)	)	-RRB-
cord-023417-by18aczt	776	25	.	.	.
cord-023417-by18aczt	777	1	Full	full	JJ
cord-023417-by18aczt	777	2	length	length	NN
cord-023417-by18aczt	778	1	BCL-6	BCL-6	NNP
cord-023417-by18aczt	778	2	cDNA	cdna	NN
cord-023417-by18aczt	778	3	was	be	VBD
cord-023417-by18aczt	778	4	retrovirally	retrovirally	RB
cord-023417-by18aczt	778	5	transduced	transduce	VBN
cord-023417-by18aczt	778	6	into	into	IN
cord-023417-by18aczt	778	7	EpH-4	EpH-4	NNP
cord-023417-by18aczt	778	8	cell	cell	NN
cord-023417-by18aczt	778	9	line	line	NN
cord-023417-by18aczt	778	10	.	.	.
cord-023417-by18aczt	779	1	We	-PRON-	PRP
cord-023417-by18aczt	779	2	then	then	RB
cord-023417-by18aczt	779	3	used	use	VBD
cord-023417-by18aczt	779	4	flow	flow	NN
cord-023417-by18aczt	779	5	cytometry	cytometry	NN
cord-023417-by18aczt	779	6	of	of	IN
cord-023417-by18aczt	779	7	BrdUrd	BrdUrd	NNP
cord-023417-by18aczt	779	8	-	-	HYPH
cord-023417-by18aczt	779	9	stained	stain	VBN
cord-023417-by18aczt	779	10	cells	cell	NNS
cord-023417-by18aczt	779	11	to	to	TO
cord-023417-by18aczt	779	12	investigate	investigate	VB
cord-023417-by18aczt	779	13	the	the	DT
cord-023417-by18aczt	779	14	cell	cell	NN
cord-023417-by18aczt	779	15	-	-	HYPH
cord-023417-by18aczt	779	16	cycle	cycle	NN
cord-023417-by18aczt	779	17	duration	duration	NN
cord-023417-by18aczt	779	18	of	of	IN
cord-023417-by18aczt	779	19	the	the	DT
cord-023417-by18aczt	779	20	control	control	NN
cord-023417-by18aczt	779	21	and	and	CC
cord-023417-by18aczt	779	22	transduced	transduce	VBD
cord-023417-by18aczt	779	23	cell	cell	NN
cord-023417-by18aczt	779	24	lines	line	NNS
cord-023417-by18aczt	779	25	.	.	.
cord-023417-by18aczt	780	1	TUNEL	TUNEL	NNP
cord-023417-by18aczt	780	2	was	be	VBD
cord-023417-by18aczt	780	3	used	use	VBN
cord-023417-by18aczt	780	4	as	as	IN
cord-023417-by18aczt	780	5	a	a	DT
cord-023417-by18aczt	780	6	marker	marker	NN
cord-023417-by18aczt	780	7	of	of	IN
cord-023417-by18aczt	780	8	apoptosis	apoptosis	NN
cord-023417-by18aczt	780	9	to	to	TO
cord-023417-by18aczt	780	10	find	find	VB
cord-023417-by18aczt	780	11	out	out	RP
cord-023417-by18aczt	780	12	differences	difference	NNS
cord-023417-by18aczt	780	13	in	in	IN
cord-023417-by18aczt	780	14	the	the	DT
cord-023417-by18aczt	780	15	frequencies	frequency	NNS
cord-023417-by18aczt	780	16	of	of	IN
cord-023417-by18aczt	780	17	apoptotic	apoptotic	JJ
cord-023417-by18aczt	780	18	cells	cell	NNS
cord-023417-by18aczt	780	19	in	in	IN
cord-023417-by18aczt	780	20	the	the	DT
cord-023417-by18aczt	780	21	control	control	NN
cord-023417-by18aczt	780	22	and	and	CC
cord-023417-by18aczt	780	23	transduced	transduce	VBD
cord-023417-by18aczt	780	24	cell	cell	NN
cord-023417-by18aczt	780	25	lines	line	NNS
cord-023417-by18aczt	780	26	.	.	.
cord-023417-by18aczt	781	1	Finally	finally	RB
cord-023417-by18aczt	781	2	,	,	,
cord-023417-by18aczt	781	3	immunohistochemistry	immunohistochemistry	NN
cord-023417-by18aczt	781	4	staining	staining	NN
cord-023417-by18aczt	781	5	was	be	VBD
cord-023417-by18aczt	781	6	performed	perform	VBN
cord-023417-by18aczt	781	7	to	to	TO
cord-023417-by18aczt	781	8	detect	detect	VB
cord-023417-by18aczt	781	9	BCL-6	BCL-6	NNP
cord-023417-by18aczt	781	10	in	in	IN
cord-023417-by18aczt	781	11	breast	breast	NN
cord-023417-by18aczt	781	12	cancer	cancer	NN
cord-023417-by18aczt	781	13	(	(	-LRB-
cord-023417-by18aczt	781	14	III	III	NNP
cord-023417-by18aczt	781	15	)	)	-RRB-
cord-023417-by18aczt	781	16	.	.	.
cord-023417-by18aczt	782	1	Results	result	NNS
cord-023417-by18aczt	782	2	:	:	:
cord-023417-by18aczt	782	3	Restoration	restoration	NN
cord-023417-by18aczt	782	4	of	of	IN
cord-023417-by18aczt	782	5	BCL-6	BCL-6	NNP
cord-023417-by18aczt	782	6	into	into	IN
cord-023417-by18aczt	782	7	EpH-4	EpH-4	NNP
cord-023417-by18aczt	782	8	cells	cell	NNS
cord-023417-by18aczt	783	1	not	not	RB
cord-023417-by18aczt	783	2	only	only	RB
cord-023417-by18aczt	783	3	inhibits	inhibit	VBZ
cord-023417-by18aczt	783	4	apoptosis	apoptosis	NN
cord-023417-by18aczt	783	5	but	but	CC
cord-023417-by18aczt	783	6	also	also	RB
cord-023417-by18aczt	783	7	prolongs	prolong	VBZ
cord-023417-by18aczt	783	8	the	the	DT
cord-023417-by18aczt	783	9	cell	cell	NN
cord-023417-by18aczt	783	10	cycle	cycle	NN
cord-023417-by18aczt	783	11	and	and	CC
cord-023417-by18aczt	783	12	results	result	NNS
cord-023417-by18aczt	783	13	in	in	IN
cord-023417-by18aczt	783	14	increased	increase	VBN
cord-023417-by18aczt	783	15	cell	cell	NN
cord-023417-by18aczt	783	16	size	size	NN
cord-023417-by18aczt	783	17	and	and	CC
cord-023417-by18aczt	783	18	protein	protein	NN
cord-023417-by18aczt	783	19	content	content	NN
cord-023417-by18aczt	783	20	.	.	.
cord-023417-by18aczt	784	1	The	the	DT
cord-023417-by18aczt	784	2	results	result	NNS
cord-023417-by18aczt	784	3	also	also	RB
cord-023417-by18aczt	784	4	indicated	indicate	VBD
cord-023417-by18aczt	784	5	that	that	IN
cord-023417-by18aczt	784	6	the	the	DT
cord-023417-by18aczt	784	7	cell	cell	NN
cord-023417-by18aczt	784	8	-	-	HYPH
cord-023417-by18aczt	784	9	cycle	cycle	NN
cord-023417-by18aczt	784	10	time	time	NN
cord-023417-by18aczt	784	11	of	of	IN
cord-023417-by18aczt	784	12	BCL-6-transduced	BCL-6-transduced	NNP
cord-023417-by18aczt	784	13	EpH-4	EpH-4	NNP
cord-023417-by18aczt	784	14	cells	cell	NNS
cord-023417-by18aczt	784	15	is	be	VBZ
cord-023417-by18aczt	784	16	prolonged	prolong	VBN
cord-023417-by18aczt	784	17	by	by	IN
cord-023417-by18aczt	784	18	about	about	RB
cord-023417-by18aczt	784	19	3	3	CD
cord-023417-by18aczt	784	20	h	h	NN
cord-023417-by18aczt	784	21	,	,	,
cord-023417-by18aczt	784	22	presumably	presumably	RB
cord-023417-by18aczt	784	23	as	as	IN
cord-023417-by18aczt	784	24	a	a	DT
cord-023417-by18aczt	784	25	result	result	NN
cord-023417-by18aczt	784	26	of	of	IN
cord-023417-by18aczt	784	27	the	the	DT
cord-023417-by18aczt	784	28	action	action	NN
cord-023417-by18aczt	784	29	of	of	IN
cord-023417-by18aczt	784	30	BCL-6	BCL-6	NNP
cord-023417-by18aczt	784	31	at	at	IN
cord-023417-by18aczt	784	32	the	the	DT
cord-023417-by18aczt	784	33	BCL-6	BCL-6	NNP
cord-023417-by18aczt	784	34	at	at	IN
cord-023417-by18aczt	784	35	the	the	DT
cord-023417-by18aczt	784	36	G1	G1	NNP
cord-023417-by18aczt	784	37	/	/	SYM
cord-023417-by18aczt	784	38	S	S	NNP
cord-023417-by18aczt	784	39	transition	transition	NN
cord-023417-by18aczt	784	40	.	.	.
cord-023417-by18aczt	785	1	We	-PRON-	PRP
cord-023417-by18aczt	785	2	found	find	VBD
cord-023417-by18aczt	785	3	differences	difference	NNS
cord-023417-by18aczt	785	4	in	in	IN
cord-023417-by18aczt	785	5	the	the	DT
cord-023417-by18aczt	785	6	frequencies	frequency	NNS
cord-023417-by18aczt	785	7	of	of	IN
cord-023417-by18aczt	785	8	viable	viable	JJ
cord-023417-by18aczt	785	9	and	and	CC
cord-023417-by18aczt	785	10	apoptotic	apoptotic	JJ
cord-023417-by18aczt	785	11	cells	cell	NNS
cord-023417-by18aczt	785	12	in	in	IN
cord-023417-by18aczt	785	13	cultures	culture	NNS
cord-023417-by18aczt	785	14	of	of	IN
cord-023417-by18aczt	785	15	the	the	DT
cord-023417-by18aczt	785	16	parent	parent	NN
cord-023417-by18aczt	785	17	EpH-4	eph-4	PRP
cord-023417-by18aczt	785	18	cells	cell	NNS
cord-023417-by18aczt	785	19	,	,	,
cord-023417-by18aczt	785	20	control	control	NN
cord-023417-by18aczt	785	21	-	-	HYPH
cord-023417-by18aczt	785	22	transduced	transduce	VBN
cord-023417-by18aczt	785	23	EpH-4	EpH-4	NNP
cord-023417-by18aczt	785	24	cells	cell	NNS
cord-023417-by18aczt	785	25	and	and	CC
cord-023417-by18aczt	785	26	BCL-6-transduced	BCL-6-transduced	NNP
cord-023417-by18aczt	785	27	EpH-4	EpH-4	NNP
cord-023417-by18aczt	785	28	cells	cell	NNS
cord-023417-by18aczt	785	29	.	.	.
cord-023417-by18aczt	786	1	Consistently	consistently	RB
cord-023417-by18aczt	786	2	,	,	,
cord-023417-by18aczt	786	3	we	-PRON-	PRP
cord-023417-by18aczt	786	4	demonstrated	demonstrate	VBD
cord-023417-by18aczt	786	5	that	that	IN
cord-023417-by18aczt	786	6	BCL-6	BCL-6	NNP
cord-023417-by18aczt	786	7	is	be	VBZ
cord-023417-by18aczt	786	8	expressed	express	VBN
cord-023417-by18aczt	786	9	in	in	IN
cord-023417-by18aczt	786	10	90	90	CD
cord-023417-by18aczt	786	11	%	%	NN
cord-023417-by18aczt	786	12	of	of	IN
cord-023417-by18aczt	786	13	high	high	JJ
cord-023417-by18aczt	786	14	grade	grade	NN
cord-023417-by18aczt	786	15	of	of	IN
cord-023417-by18aczt	786	16	breast	breast	NN
cord-023417-by18aczt	786	17	carcinoma	carcinoma	NN
cord-023417-by18aczt	786	18	,	,	,
cord-023417-by18aczt	786	19	which	which	WDT
cord-023417-by18aczt	786	20	is	be	VBZ
cord-023417-by18aczt	786	21	considered	consider	VBN
cord-023417-by18aczt	786	22	as	as	IN
cord-023417-by18aczt	786	23	the	the	DT
cord-023417-by18aczt	786	24	most	most	RBS
cord-023417-by18aczt	786	25	aggressive	aggressive	JJ
cord-023417-by18aczt	786	26	of	of	IN
cord-023417-by18aczt	786	27	tumours	tumour	NNS
cord-023417-by18aczt	786	28	.	.	.
cord-023417-by18aczt	787	1	Conclusion	conclusion	NN
cord-023417-by18aczt	787	2	:	:	:
cord-023417-by18aczt	788	1	Together	together	RB
cord-023417-by18aczt	788	2	,	,	,
cord-023417-by18aczt	788	3	these	these	DT
cord-023417-by18aczt	788	4	results	result	NNS
cord-023417-by18aczt	788	5	suggest	suggest	VBP
cord-023417-by18aczt	788	6	that	that	IN
cord-023417-by18aczt	788	7	BCL-6	BCL-6	NNP
cord-023417-by18aczt	788	8	is	be	VBZ
cord-023417-by18aczt	788	9	likely	likely	JJ
cord-023417-by18aczt	788	10	to	to	TO
cord-023417-by18aczt	788	11	be	be	VB
cord-023417-by18aczt	788	12	involved	involve	VBN
cord-023417-by18aczt	788	13	in	in	IN
cord-023417-by18aczt	788	14	mammary	mammary	JJ
cord-023417-by18aczt	788	15	gland	gland	NN
cord-023417-by18aczt	788	16	development	development	NN
cord-023417-by18aczt	788	17	and	and	CC
cord-023417-by18aczt	788	18	carcinogenesis	carcinogenesis	NN
cord-023417-by18aczt	788	19	.	.	.
cord-023417-by18aczt	789	1	Inflammatory	inflammatory	JJ
cord-023417-by18aczt	789	2	cytokines	cytokine	NNS
cord-023417-by18aczt	789	3	have	have	VBP
cord-023417-by18aczt	789	4	a	a	DT
cord-023417-by18aczt	789	5	critical	critical	JJ
cord-023417-by18aczt	789	6	role	role	NN
cord-023417-by18aczt	789	7	in	in	IN
cord-023417-by18aczt	789	8	modulation	modulation	NN
cord-023417-by18aczt	789	9	of	of	IN
cord-023417-by18aczt	789	10	both	both	DT
cord-023417-by18aczt	789	11	innate	innate	JJ
cord-023417-by18aczt	789	12	and	and	CC
cord-023417-by18aczt	789	13	adaptive	adaptive	JJ
cord-023417-by18aczt	789	14	immunity	immunity	NN
cord-023417-by18aczt	789	15	in	in	IN
cord-023417-by18aczt	789	16	response	response	NN
cord-023417-by18aczt	789	17	to	to	IN
cord-023417-by18aczt	789	18	foreign	foreign	JJ
cord-023417-by18aczt	789	19	antigen	antigen	NN
cord-023417-by18aczt	789	20	.	.	.
cord-023417-by18aczt	790	1	They	-PRON-	PRP
cord-023417-by18aczt	790	2	also	also	RB
cord-023417-by18aczt	790	3	play	play	VBP
cord-023417-by18aczt	790	4	an	an	DT
cord-023417-by18aczt	790	5	important	important	JJ
cord-023417-by18aczt	790	6	role	role	NN
cord-023417-by18aczt	790	7	in	in	IN
cord-023417-by18aczt	790	8	anticancer	anticancer	JJ
cord-023417-by18aczt	790	9	immunity	immunity	NN
cord-023417-by18aczt	790	10	.	.	.
cord-023417-by18aczt	791	1	For	for	IN
cord-023417-by18aczt	791	2	example	example	NN
cord-023417-by18aczt	791	3	,	,	,
cord-023417-by18aczt	791	4	they	-PRON-	PRP
cord-023417-by18aczt	791	5	can	can	MD
cord-023417-by18aczt	791	6	promote	promote	VB
cord-023417-by18aczt	791	7	cell	cell	NN
cord-023417-by18aczt	791	8	-	-	HYPH
cord-023417-by18aczt	791	9	mediated	mediate	VBN
cord-023417-by18aczt	791	10	immunity	immunity	NN
cord-023417-by18aczt	791	11	against	against	IN
cord-023417-by18aczt	791	12	cancer	cancer	NN
cord-023417-by18aczt	791	13	cells	cell	NNS
cord-023417-by18aczt	791	14	.	.	.
cord-023417-by18aczt	792	1	With	with	IN
cord-023417-by18aczt	792	2	their	-PRON-	PRP$
cord-023417-by18aczt	792	3	immunostimulatory	immunostimulatory	NN
cord-023417-by18aczt	792	4	effects	effect	NNS
cord-023417-by18aczt	792	5	,	,	,
cord-023417-by18aczt	792	6	these	these	DT
cord-023417-by18aczt	792	7	cytokines	cytokine	NNS
cord-023417-by18aczt	792	8	are	be	VBP
cord-023417-by18aczt	792	9	being	be	VBG
cord-023417-by18aczt	792	10	tested	test	VBN
cord-023417-by18aczt	792	11	for	for	IN
cord-023417-by18aczt	792	12	cancer	cancer	NN
cord-023417-by18aczt	792	13	treatment	treatment	NN
cord-023417-by18aczt	792	14	in	in	IN
cord-023417-by18aczt	792	15	the	the	DT
cord-023417-by18aczt	792	16	form	form	NN
cord-023417-by18aczt	792	17	of	of	IN
cord-023417-by18aczt	792	18	DNA	dna	NN
cord-023417-by18aczt	792	19	vaccine	vaccine	NN
cord-023417-by18aczt	792	20	or	or	CC
cord-023417-by18aczt	792	21	adjuvant	adjuvant	JJ
cord-023417-by18aczt	792	22	or	or	CC
cord-023417-by18aczt	792	23	therapeutic	therapeutic	JJ
cord-023417-by18aczt	792	24	cytokines	cytokine	NNS
cord-023417-by18aczt	792	25	.	.	.
cord-023417-by18aczt	793	1	Direct	direct	JJ
cord-023417-by18aczt	793	2	effect	effect	NN
cord-023417-by18aczt	793	3	of	of	IN
cord-023417-by18aczt	793	4	these	these	DT
cord-023417-by18aczt	793	5	cytokines	cytokine	NNS
cord-023417-by18aczt	793	6	on	on	IN
cord-023417-by18aczt	793	7	cancer	cancer	NN
cord-023417-by18aczt	793	8	cell	cell	NN
cord-023417-by18aczt	793	9	,	,	,
cord-023417-by18aczt	793	10	however	however	RB
cord-023417-by18aczt	793	11	,	,	,
cord-023417-by18aczt	793	12	is	be	VBZ
cord-023417-by18aczt	793	13	still	still	RB
cord-023417-by18aczt	793	14	unclear	unclear	JJ
cord-023417-by18aczt	793	15	.	.	.
cord-023417-by18aczt	794	1	In	in	IN
cord-023417-by18aczt	794	2	this	this	DT
cord-023417-by18aczt	794	3	project	project	NN
cord-023417-by18aczt	794	4	,	,	,
cord-023417-by18aczt	794	5	we	-PRON-	PRP
cord-023417-by18aczt	794	6	investigated	investigate	VBD
cord-023417-by18aczt	794	7	whether	whether	IN
cord-023417-by18aczt	794	8	IL-1	IL-1	NNP
cord-023417-by18aczt	794	9	(	(	-LRB-
cord-023417-by18aczt	794	10	and	and	CC
cord-023417-by18aczt	794	11	IL-18	IL-18	NNP
cord-023417-by18aczt	794	12	can	can	MD
cord-023417-by18aczt	794	13	modulate	modulate	VB
cord-023417-by18aczt	794	14	cancer	cancer	NN
cord-023417-by18aczt	794	15	cell	cell	NN
cord-023417-by18aczt	794	16	proliferation	proliferation	NN
cord-023417-by18aczt	794	17	.	.	.
cord-023417-by18aczt	795	1	We	-PRON-	PRP
cord-023417-by18aczt	795	2	employed	employ	VBD
cord-023417-by18aczt	795	3	a	a	DT
cord-023417-by18aczt	795	4	simple	simple	JJ
cord-023417-by18aczt	795	5	nonradioactive	nonradioactive	JJ
cord-023417-by18aczt	795	6	proliferation	proliferation	NN
cord-023417-by18aczt	795	7	(	(	-LRB-
cord-023417-by18aczt	795	8	MTT	MTT	NNP
cord-023417-by18aczt	795	9	)	)	-RRB-
cord-023417-by18aczt	795	10	assay	assay	NN
cord-023417-by18aczt	795	11	and	and	CC
cord-023417-by18aczt	795	12	detection	detection	NN
cord-023417-by18aczt	795	13	of	of	IN
cord-023417-by18aczt	795	14	lactate	lactate	NN
cord-023417-by18aczt	795	15	dehydrogenase	dehydrogenase	NN
cord-023417-by18aczt	795	16	(	(	-LRB-
cord-023417-by18aczt	795	17	LDH	LDH	NNP
cord-023417-by18aczt	795	18	)	)	-RRB-
cord-023417-by18aczt	795	19	to	to	TO
cord-023417-by18aczt	795	20	test	test	VB
cord-023417-by18aczt	795	21	the	the	DT
cord-023417-by18aczt	795	22	effect	effect	NN
cord-023417-by18aczt	795	23	of	of	IN
cord-023417-by18aczt	795	24	these	these	DT
cord-023417-by18aczt	795	25	recombinant	recombinant	JJ
cord-023417-by18aczt	795	26	human	human	JJ
cord-023417-by18aczt	795	27	cytokines	cytokine	NNS
cord-023417-by18aczt	795	28	on	on	IN
cord-023417-by18aczt	795	29	various	various	JJ
cord-023417-by18aczt	795	30	cancer	cancer	NN
cord-023417-by18aczt	795	31	cell	cell	NN
cord-023417-by18aczt	795	32	lines	line	NNS
cord-023417-by18aczt	795	33	,	,	,
cord-023417-by18aczt	795	34	including	include	VBG
cord-023417-by18aczt	795	35	breast	breast	NN
cord-023417-by18aczt	795	36	cancer	cancer	NN
cord-023417-by18aczt	795	37	cell	cell	NN
cord-023417-by18aczt	795	38	line	line	NN
cord-023417-by18aczt	795	39	(	(	-LRB-
cord-023417-by18aczt	795	40	MCF-7	MCF-7	NNP
cord-023417-by18aczt	795	41	)	)	-RRB-
cord-023417-by18aczt	795	42	,	,	,
cord-023417-by18aczt	795	43	oral	oral	JJ
cord-023417-by18aczt	795	44	carcinoma	carcinoma	NN
cord-023417-by18aczt	795	45	cell	cell	NN
cord-023417-by18aczt	795	46	line	line	NN
cord-023417-by18aczt	795	47	(	(	-LRB-
cord-023417-by18aczt	795	48	KB	KB	NNP
cord-023417-by18aczt	795	49	)	)	-RRB-
cord-023417-by18aczt	795	50	,	,	,
cord-023417-by18aczt	795	51	colon	colon	NN
cord-023417-by18aczt	795	52	cancer	cancer	NN
cord-023417-by18aczt	795	53	cell	cell	NN
cord-023417-by18aczt	795	54	line	line	NN
cord-023417-by18aczt	795	55	(	(	-LRB-
cord-023417-by18aczt	795	56	Caco-2	Caco-2	NNP
cord-023417-by18aczt	795	57	)	)	-RRB-
cord-023417-by18aczt	795	58	and	and	CC
cord-023417-by18aczt	795	59	choriocarcinoma	choriocarcinoma	NN
cord-023417-by18aczt	795	60	cell	cell	NN
cord-023417-by18aczt	795	61	line	line	NN
cord-023417-by18aczt	795	62	(	(	-LRB-
cord-023417-by18aczt	795	63	Jar	jar	NN
cord-023417-by18aczt	795	64	)	)	-RRB-
cord-023417-by18aczt	795	65	.	.	.
cord-023417-by18aczt	796	1	Cytokines	cytokine	NNS
cord-023417-by18aczt	796	2	used	use	VBN
cord-023417-by18aczt	796	3	in	in	IN
cord-023417-by18aczt	796	4	this	this	DT
cord-023417-by18aczt	796	5	study	study	NN
cord-023417-by18aczt	796	6	had	have	VBD
cord-023417-by18aczt	796	7	both	both	DT
cord-023417-by18aczt	796	8	inhibitory	inhibitory	JJ
cord-023417-by18aczt	796	9	and	and	CC
cord-023417-by18aczt	796	10	stimulatory	stimulatory	JJ
cord-023417-by18aczt	796	11	effect	effect	NN
cord-023417-by18aczt	796	12	on	on	IN
cord-023417-by18aczt	796	13	cell	cell	NN
cord-023417-by18aczt	796	14	proliferation	proliferation	NN
cord-023417-by18aczt	796	15	.	.	.
cord-023417-by18aczt	797	1	Findings	finding	NNS
cord-023417-by18aczt	797	2	in	in	IN
cord-023417-by18aczt	797	3	this	this	DT
cord-023417-by18aczt	797	4	project	project	NN
cord-023417-by18aczt	797	5	could	could	MD
cord-023417-by18aczt	797	6	provide	provide	VB
cord-023417-by18aczt	797	7	an	an	DT
cord-023417-by18aczt	797	8	insight	insight	NN
cord-023417-by18aczt	797	9	of	of	IN
cord-023417-by18aczt	797	10	cancer	cancer	NN
cord-023417-by18aczt	797	11	cell	cell	NN
cord-023417-by18aczt	797	12	response	response	NN
cord-023417-by18aczt	797	13	to	to	IN
cord-023417-by18aczt	797	14	these	these	DT
cord-023417-by18aczt	797	15	cytokines	cytokine	NNS
cord-023417-by18aczt	797	16	and	and	CC
cord-023417-by18aczt	797	17	this	this	DT
cord-023417-by18aczt	797	18	could	could	MD
cord-023417-by18aczt	797	19	lead	lead	VB
cord-023417-by18aczt	797	20	to	to	IN
cord-023417-by18aczt	797	21	a	a	DT
cord-023417-by18aczt	797	22	consideration	consideration	NN
cord-023417-by18aczt	797	23	on	on	IN
cord-023417-by18aczt	797	24	using	use	VBG
cord-023417-by18aczt	797	25	cytokine	cytokine	NN
cord-023417-by18aczt	797	26	as	as	IN
cord-023417-by18aczt	797	27	immunotherapy	immunotherapy	NN
cord-023417-by18aczt	797	28	for	for	IN
cord-023417-by18aczt	797	29	cancer	cancer	NN
cord-023417-by18aczt	797	30	treatment	treatment	NN
cord-023417-by18aczt	797	31	.	.	.
cord-023417-by18aczt	798	1	Capacity	capacity	NN
cord-023417-by18aczt	798	2	of	of	IN
cord-023417-by18aczt	798	3	AE	AE	NNP
cord-023417-by18aczt	798	4	to	to	TO
cord-023417-by18aczt	798	5	Modulate	modulate	VB
cord-023417-by18aczt	798	6	Nitric	nitric	NN
cord-023417-by18aczt	798	7	Oxide	oxide	NN
cord-023417-by18aczt	798	8	Production	production	NN
cord-023417-by18aczt	798	9	Depended	depend	VBD
cord-023417-by18aczt	798	10	on	on	IN
cord-023417-by18aczt	798	11	Intercellular	Intercellular	NNP
cord-023417-by18aczt	798	12	Contact	Contact	NNP
cord-023417-by18aczt	798	13	donor	donor	NN
cord-023417-by18aczt	798	14	T	t	NN
cord-023417-by18aczt	798	15	cells	cell	NNS
cord-023417-by18aczt	798	16	are	be	VBP
cord-023417-by18aczt	798	17	involved	involve	VBN
cord-023417-by18aczt	798	18	in	in	IN
cord-023417-by18aczt	798	19	the	the	DT
cord-023417-by18aczt	798	20	antitumour	antitumour	JJ
cord-023417-by18aczt	798	21	effects	effect	NNS
cord-023417-by18aczt	798	22	observed	observe	VBN
cord-023417-by18aczt	798	23	after	after	IN
cord-023417-by18aczt	798	24	BMT	BMT	NNP
cord-023417-by18aczt	798	25	.	.	.
cord-023417-by18aczt	799	1	Thus	thus	RB
cord-023417-by18aczt	799	2	,	,	,
cord-023417-by18aczt	799	3	patients	patient	NNS
cord-023417-by18aczt	799	4	receiving	receive	VBG
cord-023417-by18aczt	799	5	T	T	NNP
cord-023417-by18aczt	799	6	-	-	HYPH
cord-023417-by18aczt	799	7	celldepleted	celldeplete	VBN
cord-023417-by18aczt	799	8	BMT	BMT	NNP
cord-023417-by18aczt	799	9	have	have	VBP
cord-023417-by18aczt	799	10	a	a	DT
cord-023417-by18aczt	799	11	higher	high	JJR
cord-023417-by18aczt	799	12	risk	risk	NN
cord-023417-by18aczt	799	13	of	of	IN
cord-023417-by18aczt	799	14	leukaemia	leukaemia	NN
cord-023417-by18aczt	799	15	relapse	relapse	NN
cord-023417-by18aczt	799	16	compared	compare	VBN
cord-023417-by18aczt	799	17	to	to	IN
cord-023417-by18aczt	799	18	patients	patient	NNS
cord-023417-by18aczt	799	19	receiving	receive	VBG
cord-023417-by18aczt	799	20	nonmanipulated	nonmanipulate	VBN
cord-023417-by18aczt	799	21	BMT	BMT	NNP
cord-023417-by18aczt	799	22	,	,	,
cord-023417-by18aczt	799	23	and	and	CC
cord-023417-by18aczt	799	24	patients	patient	NNS
cord-023417-by18aczt	799	25	experiencing	experience	VBG
cord-023417-by18aczt	799	26	graft	graft	NN
cord-023417-by18aczt	799	27	-	-	HYPH
cord-023417-by18aczt	799	28	versus	versus	IN
cord-023417-by18aczt	799	29	-	-	HYPH
cord-023417-by18aczt	799	30	host	host	NN
cord-023417-by18aczt	799	31	disease	disease	NN
cord-023417-by18aczt	799	32	(	(	-LRB-
cord-023417-by18aczt	799	33	GVHD	GVHD	NNP
cord-023417-by18aczt	799	34	)	)	-RRB-
cord-023417-by18aczt	799	35	have	have	VBP
cord-023417-by18aczt	799	36	a	a	DT
cord-023417-by18aczt	799	37	lower	low	JJR
cord-023417-by18aczt	799	38	risk	risk	NN
cord-023417-by18aczt	799	39	of	of	IN
cord-023417-by18aczt	799	40	disease	disease	NN
cord-023417-by18aczt	799	41	relapse	relapse	NN
cord-023417-by18aczt	799	42	than	than	IN
cord-023417-by18aczt	799	43	patients	patient	NNS
cord-023417-by18aczt	799	44	who	who	WP
cord-023417-by18aczt	799	45	do	do	VBP
cord-023417-by18aczt	799	46	not	not	RB
cord-023417-by18aczt	799	47	experience	experience	VB
cord-023417-by18aczt	799	48	GVHD	GVHD	NNP
cord-023417-by18aczt	799	49	.	.	.
cord-023417-by18aczt	800	1	Although	although	IN
cord-023417-by18aczt	800	2	the	the	DT
cord-023417-by18aczt	800	3	importance	importance	NN
cord-023417-by18aczt	800	4	of	of	IN
cord-023417-by18aczt	800	5	donor	donor	NN
cord-023417-by18aczt	800	6	T	t	NN
cord-023417-by18aczt	800	7	cells	cell	NNS
cord-023417-by18aczt	800	8	for	for	IN
cord-023417-by18aczt	800	9	the	the	DT
cord-023417-by18aczt	800	10	curative	curative	JJ
cord-023417-by18aczt	800	11	action	action	NN
cord-023417-by18aczt	800	12	of	of	IN
cord-023417-by18aczt	800	13	BMT	BMT	NNP
cord-023417-by18aczt	800	14	has	have	VBZ
cord-023417-by18aczt	800	15	been	be	VBN
cord-023417-by18aczt	800	16	established	establish	VBN
cord-023417-by18aczt	800	17	,	,	,
cord-023417-by18aczt	800	18	the	the	DT
cord-023417-by18aczt	800	19	exact	exact	JJ
cord-023417-by18aczt	800	20	mechanisms	mechanism	NNS
cord-023417-by18aczt	800	21	and	and	CC
cord-023417-by18aczt	800	22	molecules	molecule	NNS
cord-023417-by18aczt	800	23	involved	involve	VBN
cord-023417-by18aczt	800	24	in	in	IN
cord-023417-by18aczt	800	25	this	this	DT
cord-023417-by18aczt	800	26	graft	graft	NN
cord-023417-by18aczt	800	27	-	-	HYPH
cord-023417-by18aczt	800	28	versus	versus	IN
cord-023417-by18aczt	800	29	-	-	HYPH
cord-023417-by18aczt	800	30	tumour	tumour	NN
cord-023417-by18aczt	800	31	effect	effect	NN
cord-023417-by18aczt	800	32	remain	remain	VBP
cord-023417-by18aczt	800	33	largely	largely	RB
cord-023417-by18aczt	800	34	unknown	unknown	JJ
cord-023417-by18aczt	800	35	.	.	.
cord-023417-by18aczt	801	1	In	in	IN
cord-023417-by18aczt	801	2	a	a	DT
cord-023417-by18aczt	801	3	recently	recently	RB
cord-023417-by18aczt	801	4	initiated	initiate	VBN
cord-023417-by18aczt	801	5	project	project	NN
cord-023417-by18aczt	801	6	,	,	,
cord-023417-by18aczt	801	7	we	-PRON-	PRP
cord-023417-by18aczt	801	8	have	have	VBP
cord-023417-by18aczt	801	9	conducted	conduct	VBN
cord-023417-by18aczt	801	10	a	a	DT
cord-023417-by18aczt	801	11	longitudinal	longitudinal	JJ
cord-023417-by18aczt	801	12	study	study	NN
cord-023417-by18aczt	801	13	of	of	IN
cord-023417-by18aczt	801	14	T	t	NN
cord-023417-by18aczt	801	15	-	-	HYPH
cord-023417-by18aczt	801	16	cell	cell	NN
cord-023417-by18aczt	801	17	clonotypes	clonotype	NNS
cord-023417-by18aczt	801	18	in	in	IN
cord-023417-by18aczt	801	19	patients	patient	NNS
cord-023417-by18aczt	801	20	who	who	WP
cord-023417-by18aczt	801	21	received	receive	VBD
cord-023417-by18aczt	801	22	peripheral	peripheral	JJ
cord-023417-by18aczt	801	23	blood	blood	NN
cord-023417-by18aczt	801	24	stem	stem	NN
cord-023417-by18aczt	801	25	cell	cell	NN
cord-023417-by18aczt	801	26	grafts	graft	NNS
cord-023417-by18aczt	801	27	after	after	IN
cord-023417-by18aczt	801	28	nonmyeloablative	nonmyeloablative	JJ
cord-023417-by18aczt	801	29	conditioning	conditioning	NN
cord-023417-by18aczt	801	30	.	.	.
cord-023417-by18aczt	802	1	Peripheral	peripheral	JJ
cord-023417-by18aczt	802	2	blood	blood	NN
cord-023417-by18aczt	802	3	samples	sample	NNS
cord-023417-by18aczt	802	4	were	be	VBD
cord-023417-by18aczt	802	5	obtained	obtain	VBN
cord-023417-by18aczt	802	6	sequentially	sequentially	RB
cord-023417-by18aczt	802	7	after	after	IN
cord-023417-by18aczt	802	8	transplant	transplant	NN
cord-023417-by18aczt	802	9	,	,	,
cord-023417-by18aczt	802	10	and	and	CC
cord-023417-by18aczt	802	11	the	the	DT
cord-023417-by18aczt	802	12	mononuclear	mononuclear	NN
cord-023417-by18aczt	802	13	cells	cell	NNS
cord-023417-by18aczt	802	14	(	(	-LRB-
cord-023417-by18aczt	802	15	MNCs	mnc	NNS
cord-023417-by18aczt	802	16	)	)	-RRB-
cord-023417-by18aczt	802	17	were	be	VBD
cord-023417-by18aczt	802	18	isolated	isolate	VBN
cord-023417-by18aczt	802	19	and	and	CC
cord-023417-by18aczt	802	20	cryopreserved	cryopreserve	VBN
cord-023417-by18aczt	802	21	.	.	.
cord-023417-by18aczt	803	1	CD8	CD8	NNP
cord-023417-by18aczt	803	2	þ	þ	NNP
cord-023417-by18aczt	803	3	T	T	NNP
cord-023417-by18aczt	803	4	cells	cell	NNS
cord-023417-by18aczt	803	5	were	be	VBD
cord-023417-by18aczt	803	6	isolated	isolate	VBN
cord-023417-by18aczt	803	7	from	from	IN
cord-023417-by18aczt	803	8	the	the	DT
cord-023417-by18aczt	803	9	MNCs	mnc	NNS
cord-023417-by18aczt	803	10	by	by	IN
cord-023417-by18aczt	803	11	use	use	NN
cord-023417-by18aczt	803	12	of	of	IN
cord-023417-by18aczt	803	13	immunomagnetic	immunomagnetic	JJ
cord-023417-by18aczt	803	14	beads	bead	NNS
cord-023417-by18aczt	803	15	or	or	CC
cord-023417-by18aczt	803	16	FACS	FACS	NNP
cord-023417-by18aczt	803	17	and	and	CC
cord-023417-by18aczt	803	18	analysed	analyse	VBD
cord-023417-by18aczt	803	19	for	for	IN
cord-023417-by18aczt	803	20	the	the	DT
cord-023417-by18aczt	803	21	presence	presence	NN
cord-023417-by18aczt	803	22	of	of	IN
cord-023417-by18aczt	803	23	clonally	clonally	RB
cord-023417-by18aczt	803	24	expanded	expand	VBN
cord-023417-by18aczt	803	25	cells	cell	NNS
cord-023417-by18aczt	803	26	by	by	IN
cord-023417-by18aczt	803	27	T	t	NN
cord-023417-by18aczt	803	28	-	-	HYPH
cord-023417-by18aczt	803	29	cell	cell	NN
cord-023417-by18aczt	803	30	receptor	receptor	NN
cord-023417-by18aczt	803	31	clonotype	clonotype	NN
cord-023417-by18aczt	803	32	mapping	mapping	NN
cord-023417-by18aczt	803	33	based	base	VBN
cord-023417-by18aczt	803	34	on	on	IN
cord-023417-by18aczt	803	35	RT	RT	NNP
cord-023417-by18aczt	803	36	-	-	HYPH
cord-023417-by18aczt	803	37	PCR	PCR	NNP
cord-023417-by18aczt	803	38	and	and	CC
cord-023417-by18aczt	803	39	denaturing	denaturing	JJ
cord-023417-by18aczt	803	40	gradient	gradient	NN
cord-023417-by18aczt	803	41	gel	gel	NN
cord-023417-by18aczt	803	42	electrophoresis	electrophoresis	NN
cord-023417-by18aczt	803	43	(	(	-LRB-
cord-023417-by18aczt	803	44	DGGE	DGGE	NNP
cord-023417-by18aczt	803	45	)	)	-RRB-
cord-023417-by18aczt	803	46	.	.	.
cord-023417-by18aczt	804	1	Using	use	VBG
cord-023417-by18aczt	804	2	this	this	DT
cord-023417-by18aczt	804	3	gel	gel	NN
cord-023417-by18aczt	804	4	-	-	HYPH
cord-023417-by18aczt	804	5	based	base	VBN
cord-023417-by18aczt	804	6	methodology	methodology	NN
cord-023417-by18aczt	804	7	,	,	,
cord-023417-by18aczt	804	8	clonally	clonally	NNP
cord-023417-by18aczt	804	9	expanded	expand	VBD
cord-023417-by18aczt	804	10	T	t	NN
cord-023417-by18aczt	804	11	cells	cell	NNS
cord-023417-by18aczt	804	12	were	be	VBD
cord-023417-by18aczt	804	13	monitored	monitor	VBN
cord-023417-by18aczt	804	14	after	after	IN
cord-023417-by18aczt	804	15	transplant	transplant	NN
cord-023417-by18aczt	804	16	and	and	CC
cord-023417-by18aczt	804	17	compared	compare	VBN
cord-023417-by18aczt	804	18	to	to	IN
cord-023417-by18aczt	804	19	the	the	DT
cord-023417-by18aczt	804	20	clinical	clinical	JJ
cord-023417-by18aczt	804	21	data	datum	NNS
cord-023417-by18aczt	804	22	of	of	IN
cord-023417-by18aczt	804	23	the	the	DT
cord-023417-by18aczt	804	24	patients	patient	NNS
cord-023417-by18aczt	804	25	.	.	.
cord-023417-by18aczt	805	1	The	the	DT
cord-023417-by18aczt	805	2	preliminary	preliminary	JJ
cord-023417-by18aczt	805	3	results	result	NNS
cord-023417-by18aczt	805	4	demonstrates	demonstrate	VBZ
cord-023417-by18aczt	805	5	the	the	DT
cord-023417-by18aczt	805	6	presence	presence	NN
cord-023417-by18aczt	805	7	of	of	IN
cord-023417-by18aczt	805	8	clonally	clonally	RB
cord-023417-by18aczt	805	9	expanded	expand	VBN
cord-023417-by18aczt	805	10	CD8	CD8	NNP
cord-023417-by18aczt	805	11	þ	þ	NNP
cord-023417-by18aczt	805	12	T	T	NNP
cord-023417-by18aczt	805	13	cells	cell	NNS
cord-023417-by18aczt	805	14	at	at	IN
cord-023417-by18aczt	805	15	all	all	DT
cord-023417-by18aczt	805	16	time	time	NN
cord-023417-by18aczt	805	17	points	point	NNS
cord-023417-by18aczt	805	18	analysed	analyse	VBN
cord-023417-by18aczt	805	19	.	.	.
cord-023417-by18aczt	806	1	Furthermore	furthermore	RB
cord-023417-by18aczt	806	2	,	,	,
cord-023417-by18aczt	806	3	a	a	DT
cord-023417-by18aczt	806	4	number	number	NN
cord-023417-by18aczt	806	5	of	of	IN
cord-023417-by18aczt	806	6	clonotypes	clonotype	NNS
cord-023417-by18aczt	806	7	persisted	persist	VBD
cord-023417-by18aczt	806	8	for	for	IN
cord-023417-by18aczt	806	9	more	more	JJR
cord-023417-by18aczt	806	10	than	than	IN
cord-023417-by18aczt	806	11	6	6	CD
cord-023417-by18aczt	806	12	months	month	NNS
cord-023417-by18aczt	806	13	,	,	,
cord-023417-by18aczt	806	14	and	and	CC
cord-023417-by18aczt	806	15	other	other	JJ
cord-023417-by18aczt	806	16	clonotypes	clonotype	NNS
cord-023417-by18aczt	806	17	emerged	emerge	VBD
cord-023417-by18aczt	806	18	during	during	IN
cord-023417-by18aczt	806	19	this	this	DT
cord-023417-by18aczt	806	20	period	period	NN
cord-023417-by18aczt	806	21	.	.	.
cord-023417-by18aczt	807	1	The	the	DT
cord-023417-by18aczt	807	2	appearance	appearance	NN
cord-023417-by18aczt	807	3	of	of	IN
cord-023417-by18aczt	807	4	newly	newly	RB
cord-023417-by18aczt	807	5	emerged	emerge	VBN
cord-023417-by18aczt	807	6	clonotypes	clonotype	NNS
cord-023417-by18aczt	807	7	which	which	WDT
cord-023417-by18aczt	807	8	coincided	coincide	VBD
cord-023417-by18aczt	807	9	with	with	IN
cord-023417-by18aczt	807	10	clinical	clinical	JJ
cord-023417-by18aczt	807	11	GVHD	GVHD	NNP
cord-023417-by18aczt	807	12	could	could	MD
cord-023417-by18aczt	807	13	indicate	indicate	VB
cord-023417-by18aczt	807	14	a	a	DT
cord-023417-by18aczt	807	15	role	role	NN
cord-023417-by18aczt	807	16	for	for	IN
cord-023417-by18aczt	807	17	these	these	DT
cord-023417-by18aczt	807	18	T	t	NN
cord-023417-by18aczt	807	19	cells	cell	NNS
cord-023417-by18aczt	807	20	in	in	IN
cord-023417-by18aczt	807	21	the	the	DT
cord-023417-by18aczt	807	22	pathogenesis	pathogenesis	NN
cord-023417-by18aczt	807	23	of	of	IN
cord-023417-by18aczt	807	24	GVHD	GVHD	NNP
cord-023417-by18aczt	807	25	.	.	.
cord-023417-by18aczt	808	1	Background	background	NN
cord-023417-by18aczt	808	2	:	:	:
cord-023417-by18aczt	809	1	Deficiency	deficiency	NN
cord-023417-by18aczt	809	2	of	of	IN
cord-023417-by18aczt	809	3	the	the	DT
cord-023417-by18aczt	809	4	mannan	mannan	NN
cord-023417-by18aczt	809	5	-	-	HYPH
cord-023417-by18aczt	809	6	binding	bind	VBG
cord-023417-by18aczt	809	7	lectin	lectin	NN
cord-023417-by18aczt	809	8	(	(	-LRB-
cord-023417-by18aczt	809	9	MBL	MBL	NNP
cord-023417-by18aczt	809	10	)	)	-RRB-
cord-023417-by18aczt	809	11	pathway	pathway	NN
cord-023417-by18aczt	809	12	of	of	IN
cord-023417-by18aczt	809	13	innate	innate	JJ
cord-023417-by18aczt	809	14	immunity	immunity	NN
cord-023417-by18aczt	809	15	leads	lead	VBZ
cord-023417-by18aczt	809	16	to	to	IN
cord-023417-by18aczt	809	17	increased	increase	VBN
cord-023417-by18aczt	809	18	susceptibility	susceptibility	NN
cord-023417-by18aczt	809	19	to	to	IN
cord-023417-by18aczt	809	20	infections	infection	NNS
cord-023417-by18aczt	809	21	.	.	.
cord-023417-by18aczt	810	1	In	in	IN
cord-023417-by18aczt	810	2	patients	patient	NNS
cord-023417-by18aczt	810	3	with	with	IN
cord-023417-by18aczt	810	4	colorectal	colorectal	JJ
cord-023417-by18aczt	810	5	cancer	cancer	NN
cord-023417-by18aczt	810	6	,	,	,
cord-023417-by18aczt	810	7	postoperative	postoperative	JJ
cord-023417-by18aczt	810	8	infection	infection	NN
cord-023417-by18aczt	810	9	is	be	VBZ
cord-023417-by18aczt	810	10	associated	associate	VBN
cord-023417-by18aczt	810	11	with	with	IN
cord-023417-by18aczt	810	12	poor	poor	JJ
cord-023417-by18aczt	810	13	prognosis	prognosis	NN
cord-023417-by18aczt	810	14	.	.	.
cord-023417-by18aczt	811	1	The	the	DT
cord-023417-by18aczt	811	2	aim	aim	NN
cord-023417-by18aczt	811	3	of	of	IN
cord-023417-by18aczt	811	4	the	the	DT
cord-023417-by18aczt	811	5	present	present	JJ
cord-023417-by18aczt	811	6	study	study	NN
cord-023417-by18aczt	811	7	was	be	VBD
cord-023417-by18aczt	811	8	to	to	TO
cord-023417-by18aczt	811	9	evaluate	evaluate	VB
cord-023417-by18aczt	811	10	(	(	-LRB-
cord-023417-by18aczt	811	11	1	1	LS
cord-023417-by18aczt	811	12	)	)	-RRB-
cord-023417-by18aczt	811	13	the	the	DT
cord-023417-by18aczt	811	14	relation	relation	NN
cord-023417-by18aczt	811	15	between	between	IN
cord-023417-by18aczt	811	16	the	the	DT
cord-023417-by18aczt	811	17	MBL	MBL	NNP
cord-023417-by18aczt	811	18	pathway	pathway	NN
cord-023417-by18aczt	811	19	and	and	CC
cord-023417-by18aczt	811	20	postoperative	postoperative	JJ
cord-023417-by18aczt	811	21	infectious	infectious	JJ
cord-023417-by18aczt	811	22	complications	complication	NNS
cord-023417-by18aczt	811	23	and	and	CC
cord-023417-by18aczt	811	24	survival	survival	NN
cord-023417-by18aczt	811	25	of	of	IN
cord-023417-by18aczt	811	26	patients	patient	NNS
cord-023417-by18aczt	811	27	resected	resect	VBN
cord-023417-by18aczt	811	28	for	for	IN
cord-023417-by18aczt	811	29	colorectal	colorectal	JJ
cord-023417-by18aczt	811	30	cancer	cancer	NN
cord-023417-by18aczt	811	31	and	and	CC
cord-023417-by18aczt	811	32	(	(	-LRB-
cord-023417-by18aczt	811	33	2	2	LS
cord-023417-by18aczt	811	34	)	)	-RRB-
cord-023417-by18aczt	811	35	the	the	DT
cord-023417-by18aczt	811	36	role	role	NN
cord-023417-by18aczt	811	37	of	of	IN
cord-023417-by18aczt	811	38	MBL	MBL	NNP
cord-023417-by18aczt	811	39	as	as	IN
cord-023417-by18aczt	811	40	acute	acute	JJ
cord-023417-by18aczt	811	41	phase	phase	NN
cord-023417-by18aczt	811	42	reactant	reactant	NN
cord-023417-by18aczt	811	43	compared	compare	VBN
cord-023417-by18aczt	811	44	to	to	IN
cord-023417-by18aczt	811	45	CRP	CRP	NNP
cord-023417-by18aczt	811	46	.	.	.
cord-023417-by18aczt	812	1	Methods	method	NNS
cord-023417-by18aczt	812	2	:	:	:
cord-023417-by18aczt	812	3	Preoperative	Preoperative	NNP
cord-023417-by18aczt	812	4	MBL	MBL	NNP
cord-023417-by18aczt	812	5	concentration	concentration	NN
cord-023417-by18aczt	812	6	,	,	,
cord-023417-by18aczt	812	7	MBL	MBL	NNP
cord-023417-by18aczt	812	8	/	/	SYM
cord-023417-by18aczt	812	9	MBLassociated	mblassociated	JJ
cord-023417-by18aczt	812	10	serine	serine	NN
cord-023417-by18aczt	812	11	protease	protease	NN
cord-023417-by18aczt	812	12	(	(	-LRB-
cord-023417-by18aczt	812	13	MASP	MASP	NNP
cord-023417-by18aczt	812	14	)	)	-RRB-
cord-023417-by18aczt	812	15	activity	activity	NN
cord-023417-by18aczt	812	16	and	and	CC
cord-023417-by18aczt	812	17	CRP	CRP	NNP
cord-023417-by18aczt	812	18	were	be	VBD
cord-023417-by18aczt	812	19	determined	determine	VBN
cord-023417-by18aczt	812	20	in	in	IN
cord-023417-by18aczt	812	21	serum	serum	NN
cord-023417-by18aczt	812	22	from	from	IN
cord-023417-by18aczt	812	23	611	611	CD
cord-023417-by18aczt	812	24	patients	patient	NNS
cord-023417-by18aczt	812	25	and	and	CC
cord-023417-by18aczt	812	26	150	150	CD
cord-023417-by18aczt	812	27	healthy	healthy	JJ
cord-023417-by18aczt	812	28	controls	control	NNS
cord-023417-by18aczt	812	29	.	.	.
cord-023417-by18aczt	813	1	The	the	DT
cord-023417-by18aczt	813	2	patients	patient	NNS
cord-023417-by18aczt	813	3	were	be	VBD
cord-023417-by18aczt	813	4	observed	observe	VBN
cord-023417-by18aczt	813	5	for	for	IN
cord-023417-by18aczt	813	6	8	8	CD
cord-023417-by18aczt	813	7	years	year	NNS
cord-023417-by18aczt	813	8	.	.	.
cord-023417-by18aczt	814	1	Postoperative	postoperative	JJ
cord-023417-by18aczt	814	2	infections	infection	NNS
cord-023417-by18aczt	814	3	,	,	,
cord-023417-by18aczt	814	4	recurrence	recurrence	NN
cord-023417-by18aczt	814	5	and	and	CC
cord-023417-by18aczt	814	6	survival	survival	NN
cord-023417-by18aczt	814	7	were	be	VBD
cord-023417-by18aczt	814	8	recorded	record	VBN
cord-023417-by18aczt	814	9	.	.	.
cord-023417-by18aczt	815	1	Results	result	NNS
cord-023417-by18aczt	815	2	:	:	:
cord-023417-by18aczt	816	1	The	the	DT
cord-023417-by18aczt	816	2	MBL	MBL	NNP
cord-023417-by18aczt	816	3	pathway	pathway	NN
cord-023417-by18aczt	816	4	components	component	NNS
cord-023417-by18aczt	816	5	were	be	VBD
cord-023417-by18aczt	816	6	increased	increase	VBN
cord-023417-by18aczt	816	7	in	in	IN
cord-023417-by18aczt	816	8	the	the	DT
cord-023417-by18aczt	816	9	patients	patient	NNS
cord-023417-by18aczt	816	10	(	(	-LRB-
cord-023417-by18aczt	816	11	P	p	NN
cord-023417-by18aczt	816	12	<	<	XX
cord-023417-by18aczt	816	13	0.0001	0.0001	CD
cord-023417-by18aczt	816	14	)	)	-RRB-
cord-023417-by18aczt	816	15	compared	compare	VBN
cord-023417-by18aczt	816	16	to	to	IN
cord-023417-by18aczt	816	17	healthy	healthy	JJ
cord-023417-by18aczt	816	18	controls	control	NNS
cord-023417-by18aczt	816	19	.	.	.
cord-023417-by18aczt	817	1	Low	low	JJ
cord-023417-by18aczt	817	2	MBL	MBL	NNP
cord-023417-by18aczt	817	3	levels	level	NNS
cord-023417-by18aczt	817	4	were	be	VBD
cord-023417-by18aczt	817	5	predictive	predictive	JJ
cord-023417-by18aczt	817	6	of	of	IN
cord-023417-by18aczt	817	7	pneumonia	pneumonia	NN
cord-023417-by18aczt	817	8	(	(	-LRB-
cord-023417-by18aczt	817	9	P	p	NN
cord-023417-by18aczt	817	10	¼	¼	CD
cord-023417-by18aczt	817	11	0.01	0.01	CD
cord-023417-by18aczt	817	12	)	)	-RRB-
cord-023417-by18aczt	817	13	,	,	,
cord-023417-by18aczt	817	14	and	and	CC
cord-023417-by18aczt	817	15	pneumonia	pneumonia	NN
cord-023417-by18aczt	817	16	(	(	-LRB-
cord-023417-by18aczt	817	17	n	n	NN
cord-023417-by18aczt	817	18	¼	¼	NNP
cord-023417-by18aczt	817	19	87	87	CD
cord-023417-by18aczt	817	20	)	)	-RRB-
cord-023417-by18aczt	817	21	was	be	VBD
cord-023417-by18aczt	817	22	associated	associate	VBN
cord-023417-by18aczt	817	23	with	with	IN
cord-023417-by18aczt	817	24	poor	poor	JJ
cord-023417-by18aczt	817	25	survival	survival	NN
cord-023417-by18aczt	817	26	(	(	-LRB-
cord-023417-by18aczt	817	27	P	p	NN
cord-023417-by18aczt	817	28	¼	¼	CD
cord-023417-by18aczt	817	29	0.003	0.003	CD
cord-023417-by18aczt	817	30	,	,	,
cord-023417-by18aczt	817	31	HR	HR	NNP
cord-023417-by18aczt	817	32	¼	¼	NNP
cord-023417-by18aczt	817	33	1.5	1.5	CD
cord-023417-by18aczt	817	34	,	,	,
cord-023417-by18aczt	817	35	95	95	CD
cord-023417-by18aczt	817	36	%	%	NN
cord-023417-by18aczt	817	37	CI	CI	NNP
cord-023417-by18aczt	817	38	1.1	1.1	CD
cord-023417-by18aczt	817	39	-	-	SYM
cord-023417-by18aczt	817	40	1.9	1.9	CD
cord-023417-by18aczt	817	41	)	)	-RRB-
cord-023417-by18aczt	817	42	.	.	.
cord-023417-by18aczt	818	1	MBL	MBL	NNP
cord-023417-by18aczt	818	2	and	and	CC
cord-023417-by18aczt	818	3	MBL/	MBL/	NNP
cord-023417-by18aczt	818	4	MASP	MASP	NNP
cord-023417-by18aczt	818	5	activity	activity	NN
cord-023417-by18aczt	818	6	could	could	MD
cord-023417-by18aczt	818	7	not	not	RB
cord-023417-by18aczt	818	8	predict	predict	VB
cord-023417-by18aczt	818	9	postoperative	postoperative	JJ
cord-023417-by18aczt	818	10	overall	overall	JJ
cord-023417-by18aczt	818	11	infections	infection	NNS
cord-023417-by18aczt	818	12	.	.	.
cord-023417-by18aczt	819	1	MBL	MBL	NNP
cord-023417-by18aczt	819	2	showed	show	VBD
cord-023417-by18aczt	819	3	no	no	DT
cord-023417-by18aczt	819	4	correlation	correlation	NN
cord-023417-by18aczt	819	5	(	(	-LRB-
cord-023417-by18aczt	819	6	spearman	spearman	NNP
cord-023417-by18aczt	819	7	's	's	POS
cord-023417-by18aczt	819	8	r	r	NNP
cord-023417-by18aczt	819	9	¼	¼	NNP
cord-023417-by18aczt	819	10	0.02	0.02	CD
cord-023417-by18aczt	819	11	,	,	,
cord-023417-by18aczt	819	12	95	95	CD
cord-023417-by18aczt	819	13	%	%	NN
cord-023417-by18aczt	820	1	CI	CI	NNP
cord-023417-by18aczt	820	2	À0.06	À0.06	NNP
cord-023417-by18aczt	820	3	-	-	HYPH
cord-023417-by18aczt	820	4	0.10	0.10	CD
cord-023417-by18aczt	820	5	)	)	-RRB-
cord-023417-by18aczt	820	6	with	with	IN
cord-023417-by18aczt	820	7	CRP	CRP	NNP
cord-023417-by18aczt	820	8	.	.	.
cord-023417-by18aczt	821	1	Conclusions	conclusion	NNS
cord-023417-by18aczt	821	2	:	:	:
cord-023417-by18aczt	822	1	Low	low	JJ
cord-023417-by18aczt	822	2	preoperative	preoperative	JJ
cord-023417-by18aczt	822	3	MBL	MBL	NNP
cord-023417-by18aczt	822	4	levels	level	NNS
cord-023417-by18aczt	822	5	are	be	VBP
cord-023417-by18aczt	822	6	predictive	predictive	JJ
cord-023417-by18aczt	822	7	of	of	IN
cord-023417-by18aczt	822	8	pneumonia	pneumonia	NN
cord-023417-by18aczt	822	9	,	,	,
cord-023417-by18aczt	822	10	which	which	WDT
cord-023417-by18aczt	822	11	is	be	VBZ
cord-023417-by18aczt	822	12	associated	associate	VBN
cord-023417-by18aczt	822	13	with	with	IN
cord-023417-by18aczt	822	14	poorer	poor	JJR
cord-023417-by18aczt	822	15	survival	survival	NN
cord-023417-by18aczt	822	16	.	.	.
cord-023417-by18aczt	823	1	MBL	MBL	NNP
cord-023417-by18aczt	823	2	concentration	concentration	NN
cord-023417-by18aczt	823	3	and	and	CC
cord-023417-by18aczt	823	4	MBL	MBL	NNP
cord-023417-by18aczt	823	5	/	/	SYM
cord-023417-by18aczt	823	6	MASP	MASP	NNP
cord-023417-by18aczt	823	7	activity	activity	NN
cord-023417-by18aczt	823	8	was	be	VBD
cord-023417-by18aczt	823	9	not	not	RB
cord-023417-by18aczt	823	10	predictive	predictive	JJ
cord-023417-by18aczt	823	11	of	of	IN
cord-023417-by18aczt	823	12	other	other	JJ
cord-023417-by18aczt	823	13	postoperative	postoperative	JJ
cord-023417-by18aczt	823	14	infections	infection	NNS
cord-023417-by18aczt	823	15	or	or	CC
cord-023417-by18aczt	823	16	long	long	JJ
cord-023417-by18aczt	823	17	-	-	HYPH
cord-023417-by18aczt	823	18	term	term	NN
cord-023417-by18aczt	823	19	prognosis	prognosis	NN
cord-023417-by18aczt	823	20	.	.	.
cord-023417-by18aczt	824	1	MBL	MBL	NNP
cord-023417-by18aczt	824	2	apparently	apparently	RB
cord-023417-by18aczt	824	3	is	be	VBZ
cord-023417-by18aczt	824	4	not	not	RB
cord-023417-by18aczt	824	5	a	a	DT
cord-023417-by18aczt	824	6	surrogate	surrogate	JJ
cord-023417-by18aczt	824	7	measure	measure	NN
cord-023417-by18aczt	824	8	of	of	IN
cord-023417-by18aczt	824	9	CRP	CRP	NNP
cord-023417-by18aczt	824	10	.	.	.
cord-023417-by18aczt	825	1	Department	Department	NNP
cord-023417-by18aczt	825	2	of	of	IN
cord-023417-by18aczt	825	3	Surgery	Surgery	NNP
cord-023417-by18aczt	825	4	,	,	,
cord-023417-by18aczt	825	5	University	University	NNP
cord-023417-by18aczt	825	6	Hospital	Hospital	NNP
cord-023417-by18aczt	825	7	of	of	IN
cord-023417-by18aczt	825	8	Erlangen	Erlangen	NNP
cord-023417-by18aczt	825	9	,	,	,
cord-023417-by18aczt	825	10	Erlangen	Erlangen	NNP
cord-023417-by18aczt	825	11	,	,	,
cord-023417-by18aczt	825	12	Germany	Germany	NNP
cord-023417-by18aczt	825	13	.	.	.
cord-023417-by18aczt	826	1	E	e	NN
cord-023417-by18aczt	826	2	-	-	NN
cord-023417-by18aczt	826	3	mail	mail	NN
cord-023417-by18aczt	826	4	:	:	:
cord-023417-by18aczt	826	5	michael.siassi@rzmail.uni-erlangen.de	michael.siassi@rzmail.uni-erlangen.de	NNP
cord-023417-by18aczt	826	6	Introduction	introduction	NN
cord-023417-by18aczt	826	7	:	:	:
cord-023417-by18aczt	827	1	The	the	DT
cord-023417-by18aczt	827	2	human	human	JJ
cord-023417-by18aczt	827	3	collectins	collectin	NNS
cord-023417-by18aczt	827	4	,	,	,
cord-023417-by18aczt	827	5	mannan	mannan	NN
cord-023417-by18aczt	827	6	-	-	HYPH
cord-023417-by18aczt	827	7	binding	bind	VBG
cord-023417-by18aczt	827	8	lectin	lectin	NN
cord-023417-by18aczt	827	9	(	(	-LRB-
cord-023417-by18aczt	827	10	MBL	MBL	NNP
cord-023417-by18aczt	827	11	)	)	-RRB-
cord-023417-by18aczt	827	12	,	,	,
cord-023417-by18aczt	827	13	surfactant	surfactant	NN
cord-023417-by18aczt	827	14	protein	protein	NN
cord-023417-by18aczt	827	15	-	-	HYPH
cord-023417-by18aczt	827	16	A	a	NN
cord-023417-by18aczt	827	17	(	(	-LRB-
cord-023417-by18aczt	827	18	SP	SP	NNP
cord-023417-by18aczt	827	19	-	-	HYPH
cord-023417-by18aczt	827	20	A	A	NNP
cord-023417-by18aczt	827	21	)	)	-RRB-
cord-023417-by18aczt	827	22	and	and	CC
cord-023417-by18aczt	827	23	surfactantprotein	surfactantprotein	NNP
cord-023417-by18aczt	827	24	-	-	HYPH
cord-023417-by18aczt	827	25	D	D	NNP
cord-023417-by18aczt	827	26	(	(	-LRB-
cord-023417-by18aczt	827	27	SP	SP	NNP
cord-023417-by18aczt	827	28	-	-	HYPH
cord-023417-by18aczt	827	29	D	D	NNP
cord-023417-by18aczt	827	30	)	)	-RRB-
cord-023417-by18aczt	827	31	play	play	VBP
cord-023417-by18aczt	827	32	a	a	DT
cord-023417-by18aczt	827	33	central	central	JJ
cord-023417-by18aczt	827	34	role	role	NN
cord-023417-by18aczt	827	35	in	in	IN
cord-023417-by18aczt	827	36	the	the	DT
cord-023417-by18aczt	827	37	innate	innate	JJ
cord-023417-by18aczt	827	38	immune	immune	JJ
cord-023417-by18aczt	827	39	system	system	NN
cord-023417-by18aczt	827	40	.	.	.
cord-023417-by18aczt	828	1	Immunological	immunological	JJ
cord-023417-by18aczt	828	2	responses	response	NNS
cord-023417-by18aczt	828	3	to	to	IN
cord-023417-by18aczt	828	4	malignant	malignant	JJ
cord-023417-by18aczt	828	5	transformation	transformation	NN
cord-023417-by18aczt	828	6	of	of	IN
cord-023417-by18aczt	828	7	epithelial	epithelial	JJ
cord-023417-by18aczt	828	8	cells	cell	NNS
cord-023417-by18aczt	828	9	gained	gain	VBD
cord-023417-by18aczt	828	10	increasing	increase	VBG
cord-023417-by18aczt	828	11	interest	interest	NN
cord-023417-by18aczt	828	12	recently	recently	RB
cord-023417-by18aczt	828	13	.	.	.
cord-023417-by18aczt	829	1	A	a	DT
cord-023417-by18aczt	829	2	former	former	JJ
cord-023417-by18aczt	829	3	study	study	NN
cord-023417-by18aczt	829	4	could	could	MD
cord-023417-by18aczt	829	5	demonstrate	demonstrate	VB
cord-023417-by18aczt	829	6	binding	binding	NN
cord-023417-by18aczt	829	7	of	of	IN
cord-023417-by18aczt	829	8	MBL	mbl	NN
cord-023417-by18aczt	829	9	to	to	IN
cord-023417-by18aczt	829	10	certain	certain	JJ
cord-023417-by18aczt	829	11	colorectal	colorectal	JJ
cord-023417-by18aczt	829	12	carcinoma	carcinoma	NN
cord-023417-by18aczt	829	13	(	(	-LRB-
cord-023417-by18aczt	829	14	CRC	CRC	NNP
cord-023417-by18aczt	829	15	)	)	-RRB-
cord-023417-by18aczt	829	16	cell	cell	NN
cord-023417-by18aczt	829	17	lines	line	NNS
cord-023417-by18aczt	829	18	in	in	IN
cord-023417-by18aczt	829	19	vitro	vitro	FW
cord-023417-by18aczt	829	20	.	.	.
cord-023417-by18aczt	830	1	We	-PRON-	PRP
cord-023417-by18aczt	830	2	therefore	therefore	RB
cord-023417-by18aczt	830	3	examined	examine	VBD
cord-023417-by18aczt	830	4	the	the	DT
cord-023417-by18aczt	830	5	expression	expression	NN
cord-023417-by18aczt	830	6	of	of	IN
cord-023417-by18aczt	830	7	human	human	JJ
cord-023417-by18aczt	830	8	collectins	collectin	NNS
cord-023417-by18aczt	830	9	in	in	IN
cord-023417-by18aczt	830	10	normal	normal	JJ
cord-023417-by18aczt	830	11	colon	colon	NN
cord-023417-by18aczt	830	12	mucosa	mucosa	NN
cord-023417-by18aczt	830	13	and	and	CC
cord-023417-by18aczt	830	14	in	in	IN
cord-023417-by18aczt	830	15	colorectal	colorectal	JJ
cord-023417-by18aczt	830	16	carcinomas	carcinoma	NNS
cord-023417-by18aczt	830	17	.	.	.
cord-023417-by18aczt	831	1	Materials	material	NNS
cord-023417-by18aczt	831	2	and	and	CC
cord-023417-by18aczt	831	3	methods	method	NNS
cord-023417-by18aczt	831	4	:	:	:
cord-023417-by18aczt	831	5	Colon	colon	NN
cord-023417-by18aczt	831	6	samples	sample	NNS
cord-023417-by18aczt	831	7	from	from	IN
cord-023417-by18aczt	831	8	20	20	CD
cord-023417-by18aczt	831	9	CRC	CRC	NNP
cord-023417-by18aczt	831	10	patients	patient	NNS
cord-023417-by18aczt	831	11	and	and	CC
cord-023417-by18aczt	831	12	10	10	CD
cord-023417-by18aczt	831	13	normal	normal	JJ
cord-023417-by18aczt	831	14	mucosa	mucosa	JJ
cord-023417-by18aczt	831	15	samples	sample	NNS
cord-023417-by18aczt	831	16	were	be	VBD
cord-023417-by18aczt	831	17	collected	collect	VBN
cord-023417-by18aczt	831	18	immediately	immediately	RB
cord-023417-by18aczt	831	19	after	after	IN
cord-023417-by18aczt	831	20	surgery	surgery	NN
cord-023417-by18aczt	831	21	.	.	.
cord-023417-by18aczt	832	1	The	the	DT
cord-023417-by18aczt	832	2	tissue	tissue	NN
cord-023417-by18aczt	832	3	was	be	VBD
cord-023417-by18aczt	832	4	microdissected	microdissecte	VBN
cord-023417-by18aczt	832	5	and	and	CC
cord-023417-by18aczt	832	6	RNA	RNA	NNP
cord-023417-by18aczt	832	7	isolated	isolate	VBD
cord-023417-by18aczt	832	8	(	(	-LRB-
cord-023417-by18aczt	832	9	Qiagen	Qiagen	NNP
cord-023417-by18aczt	832	10	,	,	,
cord-023417-by18aczt	832	11	Rneasy	Rneasy	NNP
cord-023417-by18aczt	832	12	-	-	HYPH
cord-023417-by18aczt	832	13	Kit	Kit	NNP
cord-023417-by18aczt	832	14	)	)	-RRB-
cord-023417-by18aczt	832	15	.	.	.
cord-023417-by18aczt	833	1	Gene	gene	NN
cord-023417-by18aczt	833	2	expression	expression	NN
cord-023417-by18aczt	833	3	profiles	profile	NNS
cord-023417-by18aczt	833	4	were	be	VBD
cord-023417-by18aczt	833	5	analysed	analyse	VBN
cord-023417-by18aczt	833	6	using	use	VBG
cord-023417-by18aczt	833	7	Gene	gene	NN
cord-023417-by18aczt	833	8	-	-	HYPH
cord-023417-by18aczt	833	9	chips	chip	NNS
cord-023417-by18aczt	833	10	(	(	-LRB-
cord-023417-by18aczt	833	11	Affymetrix	Affymetrix	NNP
cord-023417-by18aczt	833	12	,	,	,
cord-023417-by18aczt	833	13	HG	HG	NNP
cord-023417-by18aczt	833	14	-	-	HYPH
cord-023417-by18aczt	833	15	U133	U133	NNP
cord-023417-by18aczt	833	16	)	)	-RRB-
cord-023417-by18aczt	833	17	.	.	.
cord-023417-by18aczt	834	1	We	-PRON-	PRP
cord-023417-by18aczt	834	2	analysed	analyse	VBD
cord-023417-by18aczt	834	3	the	the	DT
cord-023417-by18aczt	834	4	data	datum	NNS
cord-023417-by18aczt	834	5	for	for	IN
cord-023417-by18aczt	834	6	the	the	DT
cord-023417-by18aczt	834	7	expression	expression	NN
cord-023417-by18aczt	834	8	of	of	IN
cord-023417-by18aczt	834	9	MBL	MBL	NNP
cord-023417-by18aczt	834	10	,	,	,
cord-023417-by18aczt	834	11	its	-PRON-	PRP$
cord-023417-by18aczt	834	12	associated	associated	JJ
cord-023417-by18aczt	834	13	serine	serine	NN
cord-023417-by18aczt	834	14	proteases	protease	NNS
cord-023417-by18aczt	834	15	mannan	mannan	NN
cord-023417-by18aczt	834	16	-	-	HYPH
cord-023417-by18aczt	834	17	binding	bind	VBG
cord-023417-by18aczt	834	18	lectinassociated	lectinassociated	JJ
cord-023417-by18aczt	834	19	serine	serine	NN
cord-023417-by18aczt	834	20	protease	protease	NN
cord-023417-by18aczt	834	21	1/2	1/2	CD
cord-023417-by18aczt	834	22	(	(	-LRB-
cord-023417-by18aczt	834	23	MASP	MASP	NNP
cord-023417-by18aczt	834	24	1/2	1/2	CD
cord-023417-by18aczt	834	25	)	)	-RRB-
cord-023417-by18aczt	834	26	,	,	,
cord-023417-by18aczt	834	27	SP	SP	NNP
cord-023417-by18aczt	834	28	-	-	HYPH
cord-023417-by18aczt	834	29	A	A	NNP
cord-023417-by18aczt	834	30	and	and	CC
cord-023417-by18aczt	834	31	SP	SP	NNP
cord-023417-by18aczt	834	32	-	-	HYPH
cord-023417-by18aczt	834	33	D.	D.	NNP
cord-023417-by18aczt	835	1	The	the	DT
cord-023417-by18aczt	835	2	signal	signal	JJ
cord-023417-by18aczt	835	3	intensity	intensity	NN
cord-023417-by18aczt	835	4	of	of	IN
cord-023417-by18aczt	835	5	the	the	DT
cord-023417-by18aczt	835	6	genes	gene	NNS
cord-023417-by18aczt	835	7	of	of	IN
cord-023417-by18aczt	835	8	interest	interest	NN
cord-023417-by18aczt	835	9	was	be	VBD
cord-023417-by18aczt	835	10	compared	compare	VBN
cord-023417-by18aczt	835	11	using	use	VBG
cord-023417-by18aczt	835	12	the	the	DT
cord-023417-by18aczt	835	13	Mann	Mann	NNP
cord-023417-by18aczt	835	14	-	-	HYPH
cord-023417-by18aczt	835	15	Whitney	Whitney	NNP
cord-023417-by18aczt	835	16	U	U	NNP
cord-023417-by18aczt	835	17	-	-	HYPH
cord-023417-by18aczt	835	18	test	test	NN
cord-023417-by18aczt	835	19	.	.	.
cord-023417-by18aczt	836	1	Results	result	NNS
cord-023417-by18aczt	836	2	:	:	:
cord-023417-by18aczt	837	1	The	the	DT
cord-023417-by18aczt	837	2	expression	expression	NN
cord-023417-by18aczt	837	3	of	of	IN
cord-023417-by18aczt	837	4	human	human	JJ
cord-023417-by18aczt	837	5	collectins	collectin	NNS
cord-023417-by18aczt	837	6	in	in	IN
cord-023417-by18aczt	837	7	normal	normal	JJ
cord-023417-by18aczt	837	8	human	human	JJ
cord-023417-by18aczt	837	9	colon	colon	NN
cord-023417-by18aczt	837	10	mucosa	mucosa	NN
cord-023417-by18aczt	837	11	was	be	VBD
cord-023417-by18aczt	837	12	generally	generally	RB
cord-023417-by18aczt	837	13	low	low	JJ
cord-023417-by18aczt	837	14	.	.	.
cord-023417-by18aczt	838	1	Only	only	RB
cord-023417-by18aczt	838	2	the	the	DT
cord-023417-by18aczt	838	3	expression	expression	NN
cord-023417-by18aczt	838	4	of	of	IN
cord-023417-by18aczt	838	5	SP	SP	NNP
cord-023417-by18aczt	838	6	-	-	HYPH
cord-023417-by18aczt	838	7	A	A	NNP
cord-023417-by18aczt	838	8	and	and	CC
cord-023417-by18aczt	838	9	MASP-2	MASP-2	NNP
cord-023417-by18aczt	838	10	reached	reach	VBD
cord-023417-by18aczt	838	11	the	the	DT
cord-023417-by18aczt	838	12	noise	noise	NN
cord-023417-by18aczt	838	13	threshold	threshold	NN
cord-023417-by18aczt	838	14	of	of	IN
cord-023417-by18aczt	838	15	250	250	CD
cord-023417-by18aczt	838	16	signals	signal	NNS
cord-023417-by18aczt	838	17	.	.	.
cord-023417-by18aczt	839	1	These	these	DT
cord-023417-by18aczt	839	2	genes	gene	NNS
cord-023417-by18aczt	839	3	were	be	VBD
cord-023417-by18aczt	839	4	significantly	significantly	RB
cord-023417-by18aczt	839	5	downregulated	downregulate	VBN
cord-023417-by18aczt	839	6	in	in	IN
cord-023417-by18aczt	839	7	CRC	CRC	NNP
cord-023417-by18aczt	839	8	specimens	specimen	NNS
cord-023417-by18aczt	839	9	.	.	.
cord-023417-by18aczt	840	1	The	the	DT
cord-023417-by18aczt	840	2	expression	expression	NN
cord-023417-by18aczt	840	3	of	of	IN
cord-023417-by18aczt	840	4	the	the	DT
cord-023417-by18aczt	840	5	other	other	JJ
cord-023417-by18aczt	840	6	proteins	protein	NNS
cord-023417-by18aczt	840	7	showed	show	VBD
cord-023417-by18aczt	840	8	no	no	DT
cord-023417-by18aczt	840	9	difference	difference	NN
cord-023417-by18aczt	840	10	in	in	IN
cord-023417-by18aczt	840	11	normal	normal	JJ
cord-023417-by18aczt	840	12	mucosa	mucosa	NN
cord-023417-by18aczt	840	13	and	and	CC
cord-023417-by18aczt	840	14	CRC	CRC	NNP
cord-023417-by18aczt	840	15	.	.	.
cord-023417-by18aczt	841	1	Conclusion	conclusion	NN
cord-023417-by18aczt	841	2	:	:	:
cord-023417-by18aczt	842	1	As	as	IN
cord-023417-by18aczt	842	2	demonstrated	demonstrate	VBN
cord-023417-by18aczt	842	3	before	before	RB
cord-023417-by18aczt	842	4	,	,	,
cord-023417-by18aczt	842	5	the	the	DT
cord-023417-by18aczt	842	6	expression	expression	NN
cord-023417-by18aczt	842	7	of	of	IN
cord-023417-by18aczt	842	8	human	human	JJ
cord-023417-by18aczt	842	9	collectins	collectin	NNS
cord-023417-by18aczt	842	10	in	in	IN
cord-023417-by18aczt	842	11	normal	normal	JJ
cord-023417-by18aczt	842	12	colon	colon	NN
cord-023417-by18aczt	842	13	was	be	VBD
cord-023417-by18aczt	842	14	low	low	JJ
cord-023417-by18aczt	842	15	in	in	IN
cord-023417-by18aczt	842	16	this	this	DT
cord-023417-by18aczt	842	17	Being	be	VBG
cord-023417-by18aczt	842	18	the	the	DT
cord-023417-by18aczt	842	19	first	first	JJ
cord-023417-by18aczt	842	20	lymph	lymph	NN
cord-023417-by18aczt	842	21	node	node	NN
cord-023417-by18aczt	842	22	to	to	TO
cord-023417-by18aczt	842	23	receive	receive	VB
cord-023417-by18aczt	842	24	drainage	drainage	NN
cord-023417-by18aczt	842	25	from	from	IN
cord-023417-by18aczt	842	26	the	the	DT
cord-023417-by18aczt	842	27	tumour	tumour	NN
cord-023417-by18aczt	842	28	area	area	NN
cord-023417-by18aczt	842	29	,	,	,
cord-023417-by18aczt	842	30	the	the	DT
cord-023417-by18aczt	842	31	sentinel	sentinel	NN
cord-023417-by18aczt	842	32	node	node	NN
cord-023417-by18aczt	842	33	offers	offer	VBZ
cord-023417-by18aczt	842	34	a	a	DT
cord-023417-by18aczt	842	35	unique	unique	JJ
cord-023417-by18aczt	842	36	possibility	possibility	NN
cord-023417-by18aczt	842	37	to	to	TO
cord-023417-by18aczt	842	38	obtain	obtain	VB
cord-023417-by18aczt	842	39	tumour	tumour	NN
cord-023417-by18aczt	842	40	-	-	HYPH
cord-023417-by18aczt	842	41	reactive	reactive	JJ
cord-023417-by18aczt	842	42	lymphocytes	lymphocyte	NNS
cord-023417-by18aczt	842	43	.	.	.
cord-023417-by18aczt	843	1	We	-PRON-	PRP
cord-023417-by18aczt	843	2	investigated	investigate	VBD
cord-023417-by18aczt	843	3	antitumour	antitumour	JJ
cord-023417-by18aczt	843	4	immune	immune	JJ
cord-023417-by18aczt	843	5	responses	response	NNS
cord-023417-by18aczt	843	6	in	in	IN
cord-023417-by18aczt	843	7	sentinel	sentinel	JJ
cord-023417-by18aczt	843	8	nodes	node	NNS
cord-023417-by18aczt	843	9	from	from	IN
cord-023417-by18aczt	843	10	patients	patient	NNS
cord-023417-by18aczt	843	11	with	with	IN
cord-023417-by18aczt	843	12	bladder	bladder	NN
cord-023417-by18aczt	843	13	cancer	cancer	NN
cord-023417-by18aczt	843	14	,	,	,
cord-023417-by18aczt	843	15	by	by	IN
cord-023417-by18aczt	843	16	assaying	assay	VBG
cord-023417-by18aczt	843	17	tumour	tumour	NN
cord-023417-by18aczt	843	18	-	-	HYPH
cord-023417-by18aczt	843	19	specific	specific	JJ
cord-023417-by18aczt	843	20	proliferation	proliferation	NN
cord-023417-by18aczt	843	21	and	and	CC
cord-023417-by18aczt	843	22	TCR	TCR	NNP
cord-023417-by18aczt	843	23	Vb	Vb	NNP
cord-023417-by18aczt	843	24	repertoires	repertoire	NNS
cord-023417-by18aczt	843	25	.	.	.
cord-023417-by18aczt	844	1	During	during	IN
cord-023417-by18aczt	844	2	tumour	tumour	NN
cord-023417-by18aczt	844	3	surgery	surgery	NN
cord-023417-by18aczt	844	4	,	,	,
cord-023417-by18aczt	844	5	sentinel	sentinel	JJ
cord-023417-by18aczt	844	6	lymph	lymph	NN
cord-023417-by18aczt	844	7	nodes	node	NNS
cord-023417-by18aczt	844	8	were	be	VBD
cord-023417-by18aczt	844	9	identified	identify	VBN
cord-023417-by18aczt	844	10	by	by	IN
cord-023417-by18aczt	844	11	peritumoural	peritumoural	JJ
cord-023417-by18aczt	844	12	injection	injection	NN
cord-023417-by18aczt	844	13	of	of	IN
cord-023417-by18aczt	844	14	blue	blue	JJ
cord-023417-by18aczt	844	15	dye	dye	NN
cord-023417-by18aczt	844	16	.	.	.
cord-023417-by18aczt	845	1	Fresh	fresh	JJ
cord-023417-by18aczt	845	2	specimens	specimen	NNS
cord-023417-by18aczt	845	3	of	of	IN
cord-023417-by18aczt	845	4	tumour	tumour	NN
cord-023417-by18aczt	845	5	,	,	,
cord-023417-by18aczt	845	6	sentinel	sentinel	NN
cord-023417-by18aczt	845	7	and	and	CC
cord-023417-by18aczt	845	8	nonsentinel	nonsentinel	JJ
cord-023417-by18aczt	845	9	lymph	lymph	NN
cord-023417-by18aczt	845	10	nodes	node	NNS
cord-023417-by18aczt	845	11	were	be	VBD
cord-023417-by18aczt	845	12	obtained	obtain	VBN
cord-023417-by18aczt	845	13	,	,	,
cord-023417-by18aczt	845	14	and	and	CC
cord-023417-by18aczt	845	15	single	single	JJ
cord-023417-by18aczt	845	16	-	-	HYPH
cord-023417-by18aczt	845	17	cell	cell	NN
cord-023417-by18aczt	845	18	suspensions	suspension	NNS
cord-023417-by18aczt	845	19	were	be	VBD
cord-023417-by18aczt	845	20	prepared	prepare	VBN
cord-023417-by18aczt	845	21	.	.	.
cord-023417-by18aczt	846	1	Cells	cell	NNS
cord-023417-by18aczt	846	2	were	be	VBD
cord-023417-by18aczt	846	3	assayed	assay	VBN
cord-023417-by18aczt	846	4	for	for	IN
cord-023417-by18aczt	846	5	reactivity	reactivity	NN
cord-023417-by18aczt	846	6	against	against	IN
cord-023417-by18aczt	846	7	autologous	autologous	JJ
cord-023417-by18aczt	846	8	tumour	tumour	NN
cord-023417-by18aczt	846	9	extract	extract	NN
cord-023417-by18aczt	846	10	in	in	IN
cord-023417-by18aczt	846	11	[	[	-LRB-
cord-023417-by18aczt	846	12	3	3	CD
cord-023417-by18aczt	846	13	H]-thymidine	H]-thymidine	NNP
cord-023417-by18aczt	846	14	incorporation	incorporation	NN
cord-023417-by18aczt	846	15	assays	assay	NNS
cord-023417-by18aczt	846	16	and	and	CC
cord-023417-by18aczt	846	17	characterized	characterize	VBN
cord-023417-by18aczt	846	18	by	by	IN
cord-023417-by18aczt	846	19	flow	flow	NN
cord-023417-by18aczt	846	20	cytometry	cytometry	NN
cord-023417-by18aczt	846	21	.	.	.
cord-023417-by18aczt	847	1	Parallel	parallel	JJ
cord-023417-by18aczt	847	2	analyses	analysis	NNS
cord-023417-by18aczt	847	3	of	of	IN
cord-023417-by18aczt	847	4	the	the	DT
cord-023417-by18aczt	847	5	expression	expression	NN
cord-023417-by18aczt	847	6	of	of	IN
cord-023417-by18aczt	847	7	Vb	Vb	NNP
cord-023417-by18aczt	847	8	gene	gene	NN
cord-023417-by18aczt	847	9	families	family	NNS
cord-023417-by18aczt	847	10	were	be	VBD
cord-023417-by18aczt	847	11	performed	perform	VBN
cord-023417-by18aczt	847	12	with	with	IN
cord-023417-by18aczt	847	13	padlock	padlock	NN
cord-023417-by18aczt	847	14	probes	probe	NNS
cord-023417-by18aczt	847	15	,	,	,
cord-023417-by18aczt	847	16	linear	linear	JJ
cord-023417-by18aczt	847	17	oligonucleotides	oligonucleotide	NNS
cord-023417-by18aczt	847	18	which	which	WDT
cord-023417-by18aczt	847	19	upon	upon	IN
cord-023417-by18aczt	847	20	target	target	NN
cord-023417-by18aczt	847	21	recognition	recognition	NN
cord-023417-by18aczt	847	22	can	can	MD
cord-023417-by18aczt	847	23	be	be	VB
cord-023417-by18aczt	847	24	converted	convert	VBN
cord-023417-by18aczt	847	25	to	to	IN
cord-023417-by18aczt	847	26	circular	circular	JJ
cord-023417-by18aczt	847	27	molecules	molecule	NNS
cord-023417-by18aczt	847	28	by	by	IN
cord-023417-by18aczt	847	29	a	a	DT
cord-023417-by18aczt	847	30	ligase	ligase	NN
cord-023417-by18aczt	847	31	.	.	.
cord-023417-by18aczt	848	1	Probes	probe	NNS
cord-023417-by18aczt	848	2	were	be	VBD
cord-023417-by18aczt	848	3	reacted	react	VBN
cord-023417-by18aczt	848	4	with	with	IN
cord-023417-by18aczt	848	5	cDNA	cdna	NN
cord-023417-by18aczt	848	6	prepared	prepare	VBN
cord-023417-by18aczt	848	7	from	from	IN
cord-023417-by18aczt	848	8	magnetically	magnetically	RB
cord-023417-by18aczt	848	9	separated	separate	VBN
cord-023417-by18aczt	848	10	CD4	CD4	NNP
cord-023417-by18aczt	848	11	þ	þ	NNP
cord-023417-by18aczt	848	12	cells	cell	NNS
cord-023417-by18aczt	848	13	,	,	,
cord-023417-by18aczt	848	14	and	and	CC
cord-023417-by18aczt	848	15	the	the	DT
cord-023417-by18aczt	848	16	TCR	TCR	NNP
cord-023417-by18aczt	848	17	repertoire	repertoire	NN
cord-023417-by18aczt	848	18	was	be	VBD
cord-023417-by18aczt	848	19	determined	determine	VBN
cord-023417-by18aczt	848	20	by	by	IN
cord-023417-by18aczt	848	21	hybridizing	hybridize	VBG
cord-023417-by18aczt	848	22	the	the	DT
cord-023417-by18aczt	848	23	products	product	NNS
cord-023417-by18aczt	848	24	to	to	IN
cord-023417-by18aczt	848	25	oligonucleotide	oligonucleotide	JJ
cord-023417-by18aczt	848	26	microarrays	microarray	NNS
cord-023417-by18aczt	848	27	.	.	.
cord-023417-by18aczt	849	1	Dose	dose	NN
cord-023417-by18aczt	849	2	-	-	HYPH
cord-023417-by18aczt	849	3	dependent	dependent	JJ
cord-023417-by18aczt	849	4	proliferation	proliferation	NN
cord-023417-by18aczt	849	5	in	in	IN
cord-023417-by18aczt	849	6	response	response	NN
cord-023417-by18aczt	849	7	to	to	TO
cord-023417-by18aczt	849	8	tumour	tumour	NN
cord-023417-by18aczt	849	9	extract	extract	NN
cord-023417-by18aczt	849	10	could	could	MD
cord-023417-by18aczt	849	11	be	be	VB
cord-023417-by18aczt	849	12	detected	detect	VBN
cord-023417-by18aczt	849	13	in	in	IN
cord-023417-by18aczt	849	14	sentinel	sentinel	JJ
cord-023417-by18aczt	849	15	lymph	lymph	NN
cord-023417-by18aczt	849	16	nodes	node	NNS
cord-023417-by18aczt	849	17	.	.	.
cord-023417-by18aczt	850	1	Common	common	JJ
cord-023417-by18aczt	850	2	clonal	clonal	JJ
cord-023417-by18aczt	850	3	expansions	expansion	NNS
cord-023417-by18aczt	850	4	were	be	VBD
cord-023417-by18aczt	850	5	detected	detect	VBN
cord-023417-by18aczt	850	6	among	among	IN
cord-023417-by18aczt	850	7	tumourinfiltrating	tumourinfiltrating	NN
cord-023417-by18aczt	850	8	lymphocytes	lymphocyte	NNS
cord-023417-by18aczt	850	9	and	and	CC
cord-023417-by18aczt	850	10	in	in	IN
cord-023417-by18aczt	850	11	sentinel	sentinel	JJ
cord-023417-by18aczt	850	12	lymph	lymph	NN
cord-023417-by18aczt	850	13	nodes	node	NNS
cord-023417-by18aczt	850	14	.	.	.
cord-023417-by18aczt	851	1	Nonsentinel	Nonsentinel	NNP
cord-023417-by18aczt	851	2	lymph	lymph	NN
cord-023417-by18aczt	851	3	nodes	node	NNS
cord-023417-by18aczt	851	4	displayed	display	VBD
cord-023417-by18aczt	851	5	a	a	DT
cord-023417-by18aczt	851	6	divergent	divergent	JJ
cord-023417-by18aczt	851	7	TCR	TCR	NNP
cord-023417-by18aczt	851	8	Vb	Vb	NNP
cord-023417-by18aczt	851	9	repertoire	repertoire	NN
cord-023417-by18aczt	851	10	.	.	.
cord-023417-by18aczt	852	1	These	these	DT
cord-023417-by18aczt	852	2	results	result	NNS
cord-023417-by18aczt	852	3	indicate	indicate	VBP
cord-023417-by18aczt	852	4	an	an	DT
cord-023417-by18aczt	852	5	ongoing	ongoing	JJ
cord-023417-by18aczt	852	6	immune	immune	JJ
cord-023417-by18aczt	852	7	response	response	NN
cord-023417-by18aczt	852	8	against	against	IN
cord-023417-by18aczt	852	9	tumour	tumour	NN
cord-023417-by18aczt	852	10	antigens	antigen	NNS
cord-023417-by18aczt	852	11	in	in	IN
cord-023417-by18aczt	852	12	sentinel	sentinel	JJ
cord-023417-by18aczt	852	13	nodes	node	NNS
cord-023417-by18aczt	852	14	,	,	,
cord-023417-by18aczt	852	15	draining	drain	VBG
cord-023417-by18aczt	852	16	urinary	urinary	JJ
cord-023417-by18aczt	852	17	bladder	bladder	NN
cord-023417-by18aczt	852	18	cancer	cancer	NN
cord-023417-by18aczt	852	19	.	.	.
cord-023417-by18aczt	853	1	Identification	identification	NN
cord-023417-by18aczt	853	2	of	of	IN
cord-023417-by18aczt	853	3	sentinel	sentinel	JJ
cord-023417-by18aczt	853	4	lymph	lymph	NN
cord-023417-by18aczt	853	5	nodes	node	NNS
cord-023417-by18aczt	853	6	makes	make	VBZ
cord-023417-by18aczt	853	7	it	-PRON-	PRP
cord-023417-by18aczt	853	8	possible	possible	JJ
cord-023417-by18aczt	853	9	to	to	TO
cord-023417-by18aczt	853	10	obtain	obtain	VB
cord-023417-by18aczt	853	11	tumour	tumour	NN
cord-023417-by18aczt	853	12	-	-	HYPH
cord-023417-by18aczt	853	13	reactive	reactive	JJ
cord-023417-by18aczt	853	14	lymphocytes	lymphocyte	NNS
cord-023417-by18aczt	853	15	for	for	IN
cord-023417-by18aczt	853	16	use	use	NN
cord-023417-by18aczt	853	17	in	in	IN
cord-023417-by18aczt	853	18	adoptive	adoptive	JJ
cord-023417-by18aczt	853	19	immunotherapy	immunotherapy	NN
cord-023417-by18aczt	853	20	.	.	.