id	sid	tid	token	lemma	pos
cord-023439-r04y1j22	1	1	key	key	NN
cord-023439-r04y1j22	1	2	:	:	:
cord-023439-r04y1j22	1	3	cord-023439-r04y1j22	cord-023439-r04y1j22	NNP
cord-023439-r04y1j22	1	4	authors	author	NNS
cord-023439-r04y1j22	1	5	:	:	:
cord-023439-r04y1j22	2	1	Hedegaard	Hedegaard	NNP
cord-023439-r04y1j22	2	2	,	,	,
cord-023439-r04y1j22	2	3	C.	C.	NNP
cord-023439-r04y1j22	2	4	J.	J.	NNP
cord-023439-r04y1j22	2	5	;	;	:
cord-023439-r04y1j22	2	6	Bendtzen	Bendtzen	NNP
cord-023439-r04y1j22	2	7	,	,	,
cord-023439-r04y1j22	2	8	K.	K.	NNP
cord-023439-r04y1j22	2	9	;	;	:
cord-023439-r04y1j22	2	10	Nielsen	Nielsen	NNP
cord-023439-r04y1j22	2	11	,	,	,
cord-023439-r04y1j22	3	1	C.	C.	NNP
cord-023439-r04y1j22	3	2	H.	H.	NNP
cord-023439-r04y1j22	3	3	title	title	NN
cord-023439-r04y1j22	3	4	:	:	:
cord-023439-r04y1j22	4	1	The	the	DT
cord-023439-r04y1j22	4	2	Role	role	NN
cord-023439-r04y1j22	4	3	of	of	IN
cord-023439-r04y1j22	4	4	Immune	Immune	NNP
cord-023439-r04y1j22	4	5	Complexes	Complexes	NNPS
cord-023439-r04y1j22	4	6	Consisting	consist	VBG
cord-023439-r04y1j22	4	7	of	of	IN
cord-023439-r04y1j22	4	8	Myelin	Myelin	NNP
cord-023439-r04y1j22	4	9	Basic	Basic	NNP
cord-023439-r04y1j22	4	10	Protein	Protein	NNP
cord-023439-r04y1j22	4	11	(	(	-LRB-
cord-023439-r04y1j22	4	12	MBP	MBP	NNP
cord-023439-r04y1j22	4	13	)	)	-RRB-
cord-023439-r04y1j22	4	14	,	,	,
cord-023439-r04y1j22	4	15	Anti‐MBP	Anti‐MBP	NNP
cord-023439-r04y1j22	4	16	Antibodies	Antibodies	NNPS
cord-023439-r04y1j22	4	17	and	and	CC
cord-023439-r04y1j22	4	18	Complement	complement	VB
cord-023439-r04y1j22	4	19	in	in	IN
cord-023439-r04y1j22	4	20	Promoting	promote	VBG
cord-023439-r04y1j22	4	21	CD4(+	cd4(+	CD
cord-023439-r04y1j22	4	22	)	)	-RRB-
cord-023439-r04y1j22	5	1	T‐cell	T‐cell	NNP
cord-023439-r04y1j22	5	2	Responses	response	NNS
cord-023439-r04y1j22	5	3	to	to	IN
cord-023439-r04y1j22	5	4	MBP	MBP	NNP
cord-023439-r04y1j22	5	5	in	in	IN
cord-023439-r04y1j22	5	6	Health	Health	NNP
cord-023439-r04y1j22	5	7	and	and	CC
cord-023439-r04y1j22	5	8	Multiple	Multiple	NNP
cord-023439-r04y1j22	5	9	Sclerosis	Sclerosis	NNP
cord-023439-r04y1j22	5	10	date	date	NN
cord-023439-r04y1j22	6	1	:	:	:
cord-023439-r04y1j22	6	2	2008	2008	CD
cord-023439-r04y1j22	6	3	-	-	SYM
cord-023439-r04y1j22	6	4	06	06	CD
cord-023439-r04y1j22	6	5	-	-	HYPH
cord-023439-r04y1j22	6	6	28	28	CD
cord-023439-r04y1j22	6	7	journal	journal	NN
cord-023439-r04y1j22	6	8	:	:	:
cord-023439-r04y1j22	7	1	Scand	Scand	NNP
cord-023439-r04y1j22	7	2	J	J	NNP
cord-023439-r04y1j22	7	3	Immunol	Immunol	NNP
cord-023439-r04y1j22	7	4	DOI	DOI	NNP
cord-023439-r04y1j22	7	5	:	:	:
cord-023439-r04y1j22	8	1	10.1111	10.1111	CD
cord-023439-r04y1j22	8	2	/	/	SYM
cord-023439-r04y1j22	8	3	j.0300	j.0300	NNP
cord-023439-r04y1j22	8	4	-	-	HYPH
cord-023439-r04y1j22	8	5	9475.2004.01423k.x	9475.2004.01423k.x	CD
cord-023439-r04y1j22	9	1	sha	sha	NNP
cord-023439-r04y1j22	9	2	:	:	:
cord-023439-r04y1j22	10	1	ea3b1c4721836f94e19de86c26c6dbeb00153b5c	ea3b1c4721836f94e19de86c26c6dbeb00153b5c	NNP
cord-023439-r04y1j22	10	2	doc_id	doc_id	NNP
cord-023439-r04y1j22	10	3	:	:	:
cord-023439-r04y1j22	10	4	23439	23439	CD
cord-023439-r04y1j22	10	5	cord_uid	cord_uid	NNS
cord-023439-r04y1j22	10	6	:	:	:
cord-023439-r04y1j22	10	7	r04y1j22	r04y1j22	.
cord-023439-r04y1j22	11	1	Multiple	multiple	JJ
cord-023439-r04y1j22	11	2	sclerosis	sclerosis	NN
cord-023439-r04y1j22	11	3	(	(	-LRB-
cord-023439-r04y1j22	11	4	MS	MS	NNP
cord-023439-r04y1j22	11	5	)	)	-RRB-
cord-023439-r04y1j22	11	6	is	be	VBZ
cord-023439-r04y1j22	11	7	an	an	DT
cord-023439-r04y1j22	11	8	autoimmune	autoimmune	JJ
cord-023439-r04y1j22	11	9	condition	condition	NN
cord-023439-r04y1j22	11	10	characterized	characterize	VBN
cord-023439-r04y1j22	11	11	by	by	IN
cord-023439-r04y1j22	11	12	degeneration	degeneration	NN
cord-023439-r04y1j22	11	13	of	of	IN
cord-023439-r04y1j22	11	14	nerve	nerve	NN
cord-023439-r04y1j22	11	15	fibre	fibre	NN
cord-023439-r04y1j22	11	16	myelin	myelin	NN
cord-023439-r04y1j22	11	17	sheets	sheet	NNS
cord-023439-r04y1j22	11	18	.	.	.
cord-023439-r04y1j22	12	1	A	a	DT
cord-023439-r04y1j22	12	2	candidate	candidate	NN
cord-023439-r04y1j22	12	3	autoantigen	autoantigen	NN
cord-023439-r04y1j22	12	4	,	,	,
cord-023439-r04y1j22	12	5	myelin	myelin	JJ
cord-023439-r04y1j22	12	6	basic	basic	JJ
cord-023439-r04y1j22	12	7	protein	protein	NN
cord-023439-r04y1j22	12	8	(	(	-LRB-
cord-023439-r04y1j22	12	9	MBP	MBP	NNP
cord-023439-r04y1j22	12	10	)	)	-RRB-
cord-023439-r04y1j22	12	11	,	,	,
cord-023439-r04y1j22	12	12	has	have	VBZ
cord-023439-r04y1j22	12	13	especially	especially	RB
cord-023439-r04y1j22	12	14	attracted	attract	VBN
cord-023439-r04y1j22	12	15	attention	attention	NN
cord-023439-r04y1j22	12	16	.	.	.
cord-023439-r04y1j22	13	1	The	the	DT
cord-023439-r04y1j22	13	2	presence	presence	NN
cord-023439-r04y1j22	13	3	of	of	IN
cord-023439-r04y1j22	13	4	anti‐MBP	anti‐mbp	JJ
cord-023439-r04y1j22	13	5	antibodies	antibody	NNS
cord-023439-r04y1j22	13	6	is	be	VBZ
cord-023439-r04y1j22	13	7	a	a	DT
cord-023439-r04y1j22	13	8	predictor	predictor	NN
cord-023439-r04y1j22	13	9	of	of	IN
cord-023439-r04y1j22	13	10	definite	definite	JJ
cord-023439-r04y1j22	13	11	MS	MS	NNP
cord-023439-r04y1j22	13	12	,	,	,
cord-023439-r04y1j22	13	13	but	but	CC
cord-023439-r04y1j22	13	14	their	-PRON-	PRP$
cord-023439-r04y1j22	13	15	role	role	NN
cord-023439-r04y1j22	13	16	in	in	IN
cord-023439-r04y1j22	13	17	the	the	DT
cord-023439-r04y1j22	13	18	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	13	19	remains	remain	VBZ
cord-023439-r04y1j22	13	20	obscure	obscure	JJ
cord-023439-r04y1j22	13	21	.	.	.
cord-023439-r04y1j22	14	1	T	t	NN
cord-023439-r04y1j22	14	2	cells	cell	NNS
cord-023439-r04y1j22	14	3	have	have	VBP
cord-023439-r04y1j22	14	4	long	long	RB
cord-023439-r04y1j22	14	5	been	be	VBN
cord-023439-r04y1j22	14	6	known	know	VBN
cord-023439-r04y1j22	14	7	to	to	TO
cord-023439-r04y1j22	14	8	play	play	VB
cord-023439-r04y1j22	14	9	a	a	DT
cord-023439-r04y1j22	14	10	pivotal	pivotal	JJ
cord-023439-r04y1j22	14	11	role	role	NN
cord-023439-r04y1j22	14	12	in	in	IN
cord-023439-r04y1j22	14	13	the	the	DT
cord-023439-r04y1j22	14	14	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	14	15	of	of	IN
cord-023439-r04y1j22	14	16	MS	MS	NNP
cord-023439-r04y1j22	14	17	.	.	.
cord-023439-r04y1j22	15	1	Recently	recently	RB
cord-023439-r04y1j22	15	2	,	,	,
cord-023439-r04y1j22	15	3	an	an	DT
cord-023439-r04y1j22	15	4	important	important	JJ
cord-023439-r04y1j22	15	5	role	role	NN
cord-023439-r04y1j22	15	6	for	for	IN
cord-023439-r04y1j22	15	7	B	b	NN
cord-023439-r04y1j22	15	8	cells	cell	NNS
cord-023439-r04y1j22	15	9	as	as	IN
cord-023439-r04y1j22	15	10	autoantigen‐presenting	autoantigen‐presenting	NNP
cord-023439-r04y1j22	15	11	cells	cell	NNS
cord-023439-r04y1j22	15	12	has	have	VBZ
cord-023439-r04y1j22	15	13	been	be	VBN
cord-023439-r04y1j22	15	14	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	15	15	in	in	IN
cord-023439-r04y1j22	15	16	other	other	JJ
cord-023439-r04y1j22	15	17	autoimmune	autoimmune	JJ
cord-023439-r04y1j22	15	18	diseases	disease	NNS
cord-023439-r04y1j22	15	19	,	,	,
cord-023439-r04y1j22	15	20	including	include	VBG
cord-023439-r04y1j22	15	21	rheumatoid	rheumatoid	NN
cord-023439-r04y1j22	15	22	arthritis	arthritis	NN
cord-023439-r04y1j22	15	23	and	and	CC
cord-023439-r04y1j22	15	24	diabetes	diabetes	NN
cord-023439-r04y1j22	15	25	.	.	.
cord-023439-r04y1j22	16	1	The	the	DT
cord-023439-r04y1j22	16	2	uptake	uptake	NN
cord-023439-r04y1j22	16	3	of	of	IN
cord-023439-r04y1j22	16	4	MBP	MBP	NNP
cord-023439-r04y1j22	16	5	by	by	IN
cord-023439-r04y1j22	16	6	B	b	NN
cord-023439-r04y1j22	16	7	cells	cell	NNS
cord-023439-r04y1j22	16	8	and	and	CC
cord-023439-r04y1j22	16	9	the	the	DT
cord-023439-r04y1j22	16	10	presentation	presentation	NN
cord-023439-r04y1j22	16	11	of	of	IN
cord-023439-r04y1j22	16	12	MBP‐derive	mbp‐derive	JJ
cord-023439-r04y1j22	16	13	peptides	peptide	NNS
cord-023439-r04y1j22	16	14	to	to	IN
cord-023439-r04y1j22	16	15	T	T	NNP
cord-023439-r04y1j22	16	16	helper	helper	NN
cord-023439-r04y1j22	16	17	(	(	-LRB-
cord-023439-r04y1j22	16	18	Th	Th	NNP
cord-023439-r04y1j22	16	19	)	)	-RRB-
cord-023439-r04y1j22	16	20	cells	cell	NNS
cord-023439-r04y1j22	16	21	by	by	IN
cord-023439-r04y1j22	16	22	B	b	NN
cord-023439-r04y1j22	16	23	cells	cell	NNS
cord-023439-r04y1j22	16	24	may	may	MD
cord-023439-r04y1j22	16	25	be	be	VB
cord-023439-r04y1j22	16	26	promoted	promote	VBN
cord-023439-r04y1j22	16	27	by	by	IN
cord-023439-r04y1j22	16	28	the	the	DT
cord-023439-r04y1j22	16	29	formation	formation	NN
cord-023439-r04y1j22	16	30	of	of	IN
cord-023439-r04y1j22	16	31	complement	complement	NN
cord-023439-r04y1j22	16	32	(	(	-LRB-
cord-023439-r04y1j22	16	33	C	c	NN
cord-023439-r04y1j22	16	34	)	)	-RRB-
cord-023439-r04y1j22	16	35	activating	activate	VBG
cord-023439-r04y1j22	16	36	immune	immune	JJ
cord-023439-r04y1j22	16	37	complexes	complex	NNS
cord-023439-r04y1j22	16	38	(	(	-LRB-
cord-023439-r04y1j22	16	39	ICs	ICs	NNP
cord-023439-r04y1j22	16	40	)	)	-RRB-
cord-023439-r04y1j22	16	41	between	between	IN
cord-023439-r04y1j22	16	42	MBP	MBP	NNP
cord-023439-r04y1j22	16	43	and	and	CC
cord-023439-r04y1j22	16	44	natural	natural	JJ
cord-023439-r04y1j22	16	45	autoantibodies	autoantibody	NNS
cord-023439-r04y1j22	16	46	in	in	IN
cord-023439-r04y1j22	16	47	healthy	healthy	JJ
cord-023439-r04y1j22	16	48	individuals	individual	NNS
cord-023439-r04y1j22	16	49	and	and	CC
cord-023439-r04y1j22	16	50	disease‐associated	disease‐associated	JJ
cord-023439-r04y1j22	16	51	anti‐MBP	anti‐mbp	JJ
cord-023439-r04y1j22	16	52	antibodies	antibody	NNS
cord-023439-r04y1j22	16	53	in	in	IN
cord-023439-r04y1j22	16	54	MS	MS	NNP
cord-023439-r04y1j22	16	55	patients	patient	NNS
cord-023439-r04y1j22	16	56	,	,	,
cord-023439-r04y1j22	16	57	respectively	respectively	RB
cord-023439-r04y1j22	16	58	.	.	.
cord-023439-r04y1j22	17	1	We	-PRON-	PRP
cord-023439-r04y1j22	17	2	have	have	VBP
cord-023439-r04y1j22	17	3	investigated	investigate	VBN
cord-023439-r04y1j22	17	4	the	the	DT
cord-023439-r04y1j22	17	5	formation	formation	NN
cord-023439-r04y1j22	17	6	of	of	IN
cord-023439-r04y1j22	17	7	MBP‐containing	mbp‐containe	VBG
cord-023439-r04y1j22	17	8	IC	IC	NNP
cord-023439-r04y1j22	17	9	,	,	,
cord-023439-r04y1j22	17	10	the	the	DT
cord-023439-r04y1j22	17	11	binding	binding	NN
cord-023439-r04y1j22	17	12	of	of	IN
cord-023439-r04y1j22	17	13	MBP	MBP	NNP
cord-023439-r04y1j22	17	14	to	to	IN
cord-023439-r04y1j22	17	15	B	b	NN
cord-023439-r04y1j22	17	16	cells	cell	NNS
cord-023439-r04y1j22	17	17	,	,	,
cord-023439-r04y1j22	17	18	the	the	DT
cord-023439-r04y1j22	17	19	MBP‐elicited	mbp‐elicited	JJ
cord-023439-r04y1j22	17	20	induction	induction	NN
cord-023439-r04y1j22	17	21	of	of	IN
cord-023439-r04y1j22	17	22	Th‐cell	Th‐cell	NNP
cord-023439-r04y1j22	18	1	and	and	CC
cord-023439-r04y1j22	18	2	B‐cell	B‐cell	NNP
cord-023439-r04y1j22	18	3	proliferation	proliferation	NN
cord-023439-r04y1j22	18	4	and	and	CC
cord-023439-r04y1j22	18	5	the	the	DT
cord-023439-r04y1j22	18	6	cytokine	cytokine	NN
cord-023439-r04y1j22	18	7	production	production	NN
cord-023439-r04y1j22	18	8	in	in	IN
cord-023439-r04y1j22	18	9	peripheral	peripheral	JJ
cord-023439-r04y1j22	18	10	blood	blood	NN
cord-023439-r04y1j22	18	11	mononuclear	mononuclear	NN
cord-023439-r04y1j22	18	12	cells	cell	NNS
cord-023439-r04y1j22	18	13	(	(	-LRB-
cord-023439-r04y1j22	18	14	PBMCs	pbmc	NNS
cord-023439-r04y1j22	18	15	)	)	-RRB-
cord-023439-r04y1j22	18	16	from	from	IN
cord-023439-r04y1j22	18	17	healthy	healthy	JJ
cord-023439-r04y1j22	18	18	donors	donor	NNS
cord-023439-r04y1j22	18	19	grown	grow	VBN
cord-023439-r04y1j22	18	20	in	in	IN
cord-023439-r04y1j22	18	21	the	the	DT
cord-023439-r04y1j22	18	22	presence	presence	NN
cord-023439-r04y1j22	18	23	of	of	IN
cord-023439-r04y1j22	18	24	intact	intact	JJ
cord-023439-r04y1j22	18	25	or	or	CC
cord-023439-r04y1j22	18	26	C‐inactivated	c‐inactivated	JJ
cord-023439-r04y1j22	18	27	serum	serum	NN
cord-023439-r04y1j22	18	28	from	from	IN
cord-023439-r04y1j22	18	29	healthy	healthy	JJ
cord-023439-r04y1j22	18	30	donors	donor	NNS
cord-023439-r04y1j22	18	31	or	or	CC
cord-023439-r04y1j22	18	32	patients	patient	NNS
cord-023439-r04y1j22	18	33	with	with	IN
cord-023439-r04y1j22	18	34	MS	MS	NNP
cord-023439-r04y1j22	18	35	.	.	.
cord-023439-r04y1j22	19	1	While	while	IN
cord-023439-r04y1j22	19	2	MBP	MBP	NNP
cord-023439-r04y1j22	19	3	did	do	VBD
cord-023439-r04y1j22	19	4	not	not	RB
cord-023439-r04y1j22	19	5	induce	induce	VB
cord-023439-r04y1j22	19	6	measurable	measurable	JJ
cord-023439-r04y1j22	19	7	proliferation	proliferation	NN
cord-023439-r04y1j22	19	8	of	of	IN
cord-023439-r04y1j22	19	9	B	b	NN
cord-023439-r04y1j22	19	10	cells	cell	NNS
cord-023439-r04y1j22	19	11	nor	nor	CC
cord-023439-r04y1j22	19	12	CD4(+	cd4(+	JJ
cord-023439-r04y1j22	19	13	)	)	-RRB-
cord-023439-r04y1j22	19	14	T	t	NN
cord-023439-r04y1j22	19	15	cells	cell	NNS
cord-023439-r04y1j22	19	16	,	,	,
cord-023439-r04y1j22	19	17	we	-PRON-	PRP
cord-023439-r04y1j22	19	18	observed	observe	VBD
cord-023439-r04y1j22	19	19	the	the	DT
cord-023439-r04y1j22	19	20	production	production	NN
cord-023439-r04y1j22	19	21	of	of	IN
cord-023439-r04y1j22	19	22	TNF‐α	tnf‐α	NN
cord-023439-r04y1j22	19	23	,	,	,
cord-023439-r04y1j22	19	24	IFN‐γ	ifn‐γ	NN
cord-023439-r04y1j22	19	25	and	and	CC
cord-023439-r04y1j22	19	26	IL‐10	IL‐10	VBN
cord-023439-r04y1j22	19	27	by	by	IN
cord-023439-r04y1j22	19	28	PBMC	PBMC	NNP
cord-023439-r04y1j22	19	29	in	in	IN
cord-023439-r04y1j22	19	30	response	response	NN
cord-023439-r04y1j22	19	31	to	to	IN
cord-023439-r04y1j22	19	32	incubation	incubation	NN
cord-023439-r04y1j22	19	33	with	with	IN
cord-023439-r04y1j22	19	34	MBP	MBP	NNP
cord-023439-r04y1j22	19	35	in	in	IN
cord-023439-r04y1j22	19	36	the	the	DT
cord-023439-r04y1j22	19	37	presence	presence	NN
cord-023439-r04y1j22	19	38	of	of	IN
cord-023439-r04y1j22	19	39	sera	sera	NNP
cord-023439-r04y1j22	19	40	from	from	IN
cord-023439-r04y1j22	19	41	healthy	healthy	JJ
cord-023439-r04y1j22	19	42	controls	control	NNS
cord-023439-r04y1j22	19	43	as	as	RB
cord-023439-r04y1j22	19	44	well	well	RB
cord-023439-r04y1j22	19	45	as	as	IN
cord-023439-r04y1j22	19	46	sera	sera	NNP
cord-023439-r04y1j22	19	47	from	from	IN
cord-023439-r04y1j22	19	48	MS	MS	NNP
cord-023439-r04y1j22	19	49	patients	patient	NNS
cord-023439-r04y1j22	19	50	.	.	.
cord-023439-r04y1j22	20	1	By	by	IN
cord-023439-r04y1j22	20	2	contrast	contrast	NN
cord-023439-r04y1j22	20	3	,	,	,
cord-023439-r04y1j22	20	4	no	no	DT
cord-023439-r04y1j22	20	5	production	production	NN
cord-023439-r04y1j22	20	6	of	of	IN
cord-023439-r04y1j22	20	7	IL‐2	il‐2	NN
cord-023439-r04y1j22	20	8	,	,	,
cord-023439-r04y1j22	20	9	IL‐4	il‐4	NN
cord-023439-r04y1j22	20	10	and	and	CC
cord-023439-r04y1j22	20	11	IL‐5	il‐5	NN
cord-023439-r04y1j22	20	12	was	be	VBD
cord-023439-r04y1j22	20	13	detected	detect	VBN
cord-023439-r04y1j22	20	14	.	.	.
cord-023439-r04y1j22	21	1	We	-PRON-	PRP
cord-023439-r04y1j22	21	2	are	be	VBP
cord-023439-r04y1j22	21	3	currently	currently	RB
cord-023439-r04y1j22	21	4	investigating	investigate	VBG
cord-023439-r04y1j22	21	5	the	the	DT
cord-023439-r04y1j22	21	6	capability	capability	NN
cord-023439-r04y1j22	21	7	of	of	IN
cord-023439-r04y1j22	21	8	MS	MS	NNP
cord-023439-r04y1j22	21	9	sera	sera	NNP
cord-023439-r04y1j22	21	10	to	to	TO
cord-023439-r04y1j22	21	11	promote	promote	VB
cord-023439-r04y1j22	21	12	the	the	DT
cord-023439-r04y1j22	21	13	formation	formation	NN
cord-023439-r04y1j22	21	14	of	of	IN
cord-023439-r04y1j22	21	15	MBP‐containing	mbp‐containe	VBG
cord-023439-r04y1j22	21	16	IC	IC	NNP
cord-023439-r04y1j22	21	17	and	and	CC
cord-023439-r04y1j22	21	18	thereby	thereby	RB
cord-023439-r04y1j22	21	19	enhance	enhance	VB
cord-023439-r04y1j22	21	20	the	the	DT
cord-023439-r04y1j22	21	21	cytokine	cytokine	NN
cord-023439-r04y1j22	21	22	responses	response	NNS
cord-023439-r04y1j22	21	23	,	,	,
cord-023439-r04y1j22	21	24	by	by	IN
cord-023439-r04y1j22	21	25	virtue	virtue	NN
cord-023439-r04y1j22	21	26	of	of	IN
cord-023439-r04y1j22	21	27	elevated	elevated	JJ
cord-023439-r04y1j22	21	28	anti‐MBP	anti‐mbp	JJ
cord-023439-r04y1j22	21	29	contents	content	NNS
cord-023439-r04y1j22	21	30	.	.	.
cord-023439-r04y1j22	22	1	The	the	DT
cord-023439-r04y1j22	22	2	nuclear	nuclear	JJ
cord-023439-r04y1j22	22	3	receptor	receptor	NN
cord-023439-r04y1j22	22	4	heterodimers	heterodimer	NNS
cord-023439-r04y1j22	22	5	of	of	IN
cord-023439-r04y1j22	22	6	liver	liver	NN
cord-023439-r04y1j22	22	7	X	x	NN
cord-023439-r04y1j22	22	8	receptors	receptor	NNS
cord-023439-r04y1j22	22	9	(	(	-LRB-
cord-023439-r04y1j22	22	10	LXRs	LXRs	NNP
cord-023439-r04y1j22	22	11	)	)	-RRB-
cord-023439-r04y1j22	22	12	are	be	VBP
cord-023439-r04y1j22	22	13	recently	recently	RB
cord-023439-r04y1j22	22	14	identified	identify	VBN
cord-023439-r04y1j22	22	15	as	as	IN
cord-023439-r04y1j22	22	16	key	key	JJ
cord-023439-r04y1j22	22	17	transcriptional	transcriptional	JJ
cord-023439-r04y1j22	22	18	regulators	regulator	NNS
cord-023439-r04y1j22	22	19	of	of	IN
cord-023439-r04y1j22	22	20	genes	gene	NNS
cord-023439-r04y1j22	22	21	involved	involve	VBN
cord-023439-r04y1j22	22	22	in	in	IN
cord-023439-r04y1j22	22	23	lipid	lipid	NN
cord-023439-r04y1j22	22	24	homeostasis	homeostasis	NN
cord-023439-r04y1j22	22	25	and	and	CC
cord-023439-r04y1j22	22	26	inflammation	inflammation	NN
cord-023439-r04y1j22	22	27	.	.	.
cord-023439-r04y1j22	23	1	LXRs	LXRs	NNP
cord-023439-r04y1j22	23	2	and	and	CC
cord-023439-r04y1j22	23	3	their	-PRON-	PRP$
cord-023439-r04y1j22	23	4	ligands	ligand	NNS
cord-023439-r04y1j22	23	5	are	be	VBP
cord-023439-r04y1j22	23	6	negative	negative	JJ
cord-023439-r04y1j22	23	7	regulators	regulator	NNS
cord-023439-r04y1j22	23	8	of	of	IN
cord-023439-r04y1j22	23	9	macrophage	macrophage	NN
cord-023439-r04y1j22	23	10	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	23	11	gene	gene	NN
cord-023439-r04y1j22	23	12	expression	expression	NN
cord-023439-r04y1j22	23	13	.	.	.
cord-023439-r04y1j22	24	1	Multiple	multiple	JJ
cord-023439-r04y1j22	24	2	sclerosis	sclerosis	NN
cord-023439-r04y1j22	24	3	(	(	-LRB-
cord-023439-r04y1j22	24	4	MS	MS	NNP
cord-023439-r04y1j22	24	5	)	)	-RRB-
cord-023439-r04y1j22	24	6	,	,	,
cord-023439-r04y1j22	24	7	a	a	DT
cord-023439-r04y1j22	24	8	demyelinating	demyelinating	JJ
cord-023439-r04y1j22	24	9	disease	disease	NN
cord-023439-r04y1j22	24	10	of	of	IN
cord-023439-r04y1j22	24	11	the	the	DT
cord-023439-r04y1j22	24	12	central	central	JJ
cord-023439-r04y1j22	24	13	nervous	nervous	JJ
cord-023439-r04y1j22	24	14	system	system	NN
cord-023439-r04y1j22	24	15	of	of	IN
cord-023439-r04y1j22	24	16	unknown	unknown	JJ
cord-023439-r04y1j22	24	17	cause	cause	NN
cord-023439-r04y1j22	24	18	,	,	,
cord-023439-r04y1j22	24	19	is	be	VBZ
cord-023439-r04y1j22	24	20	characterized	characterize	VBN
cord-023439-r04y1j22	24	21	by	by	IN
cord-023439-r04y1j22	24	22	recurrent	recurrent	JJ
cord-023439-r04y1j22	24	23	inflammation	inflammation	NN
cord-023439-r04y1j22	24	24	involving	involve	VBG
cord-023439-r04y1j22	24	25	macrophages	macrophage	NNS
cord-023439-r04y1j22	24	26	and	and	CC
cord-023439-r04y1j22	24	27	their	-PRON-	PRP$
cord-023439-r04y1j22	24	28	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	24	29	mediators	mediator	NNS
cord-023439-r04y1j22	24	30	.	.	.
cord-023439-r04y1j22	25	1	Sweden	Sweden	NNP
cord-023439-r04y1j22	25	2	belongs	belong	VBZ
cord-023439-r04y1j22	25	3	to	to	IN
cord-023439-r04y1j22	25	4	the	the	DT
cord-023439-r04y1j22	25	5	countries	country	NNS
cord-023439-r04y1j22	25	6	with	with	IN
cord-023439-r04y1j22	25	7	a	a	DT
cord-023439-r04y1j22	25	8	high	high	JJ
cord-023439-r04y1j22	25	9	MS	MS	NNP
cord-023439-r04y1j22	25	10	incidence	incidence	NN
cord-023439-r04y1j22	25	11	.	.	.
cord-023439-r04y1j22	26	1	In	in	IN
cord-023439-r04y1j22	26	2	Italy	Italy	NNP
cord-023439-r04y1j22	26	3	,	,	,
cord-023439-r04y1j22	26	4	incidence	incidence	NN
cord-023439-r04y1j22	26	5	is	be	VBZ
cord-023439-r04y1j22	26	6	lower	low	JJR
cord-023439-r04y1j22	26	7	,	,	,
cord-023439-r04y1j22	26	8	with	with	IN
cord-023439-r04y1j22	26	9	an	an	DT
cord-023439-r04y1j22	26	10	exception	exception	NN
cord-023439-r04y1j22	26	11	for	for	IN
cord-023439-r04y1j22	26	12	Sardinia	Sardinia	NNP
cord-023439-r04y1j22	26	13	where	where	WRB
cord-023439-r04y1j22	26	14	the	the	DT
cord-023439-r04y1j22	26	15	incidence	incidence	NN
cord-023439-r04y1j22	26	16	is	be	VBZ
cord-023439-r04y1j22	26	17	even	even	RB
cord-023439-r04y1j22	26	18	higher	high	JJR
cord-023439-r04y1j22	26	19	than	than	IN
cord-023439-r04y1j22	26	20	that	that	DT
cord-023439-r04y1j22	26	21	in	in	IN
cord-023439-r04y1j22	26	22	Sweden	Sweden	NNP
cord-023439-r04y1j22	26	23	.	.	.
cord-023439-r04y1j22	27	1	Subjects	subject	NNS
cord-023439-r04y1j22	27	2	from	from	IN
cord-023439-r04y1j22	27	3	Sardinia	Sardinia	NNP
cord-023439-r04y1j22	27	4	are	be	VBP
cord-023439-r04y1j22	27	5	ethnically	ethnically	RB
cord-023439-r04y1j22	27	6	more	more	RBR
cord-023439-r04y1j22	27	7	homogeneous	homogeneous	JJ
cord-023439-r04y1j22	27	8	and	and	CC
cord-023439-r04y1j22	27	9	differ	differ	VBP
cord-023439-r04y1j22	27	10	from	from	IN
cord-023439-r04y1j22	27	11	Swedes	Swedes	NNPS
cord-023439-r04y1j22	27	12	,	,	,
cord-023439-r04y1j22	27	13	also	also	RB
cord-023439-r04y1j22	27	14	regarding	regard	VBG
cord-023439-r04y1j22	27	15	genetic	genetic	JJ
cord-023439-r04y1j22	27	16	background	background	NN
cord-023439-r04y1j22	27	17	and	and	CC
cord-023439-r04y1j22	27	18	environment	environment	NN
cord-023439-r04y1j22	27	19	.	.	.
cord-023439-r04y1j22	28	1	We	-PRON-	PRP
cord-023439-r04y1j22	28	2	studied	study	VBD
cord-023439-r04y1j22	28	3	LXRs	lxr	NNS
cord-023439-r04y1j22	28	4	and	and	CC
cord-023439-r04y1j22	28	5	their	-PRON-	PRP$
cord-023439-r04y1j22	28	6	related	related	JJ
cord-023439-r04y1j22	28	7	molecules	molecule	NNS
cord-023439-r04y1j22	28	8	of	of	IN
cord-023439-r04y1j22	28	9	blood	blood	NN
cord-023439-r04y1j22	28	10	mononuclear	mononuclear	NN
cord-023439-r04y1j22	28	11	cells	cell	NNS
cord-023439-r04y1j22	28	12	(	(	-LRB-
cord-023439-r04y1j22	28	13	MNCs	mnc	NNS
cord-023439-r04y1j22	28	14	)	)	-RRB-
cord-023439-r04y1j22	28	15	from	from	IN
cord-023439-r04y1j22	28	16	female	female	JJ
cord-023439-r04y1j22	28	17	patients	patient	NNS
cord-023439-r04y1j22	28	18	with	with	IN
cord-023439-r04y1j22	28	19	untreated	untreated	JJ
cord-023439-r04y1j22	28	20	relapsing	relapse	VBG
cord-023439-r04y1j22	28	21	-	-	HYPH
cord-023439-r04y1j22	28	22	remitting	remit	VBG
cord-023439-r04y1j22	28	23	MS	MS	NNP
cord-023439-r04y1j22	28	24	from	from	IN
cord-023439-r04y1j22	28	25	Sassari	Sassari	NNP
cord-023439-r04y1j22	28	26	,	,	,
cord-023439-r04y1j22	28	27	Sardinia	Sardinia	NNP
cord-023439-r04y1j22	28	28	and	and	CC
cord-023439-r04y1j22	28	29	Stockholm	Stockholm	NNP
cord-023439-r04y1j22	28	30	,	,	,
cord-023439-r04y1j22	28	31	Sweden	Sweden	NNP
cord-023439-r04y1j22	28	32	.	.	.
cord-023439-r04y1j22	29	1	Sex	sex	NN
cord-023439-r04y1j22	29	2	-	-	HYPH
cord-023439-r04y1j22	29	3	and	and	CC
cord-023439-r04y1j22	29	4	age	age	NN
cord-023439-r04y1j22	29	5	-	-	HYPH
cord-023439-r04y1j22	29	6	matched	match	VBN
cord-023439-r04y1j22	29	7	healthy	healthy	JJ
cord-023439-r04y1j22	29	8	controls	control	NNS
cord-023439-r04y1j22	29	9	(	(	-LRB-
cord-023439-r04y1j22	29	10	HCs	HCs	NNP
cord-023439-r04y1j22	29	11	)	)	-RRB-
cord-023439-r04y1j22	29	12	were	be	VBD
cord-023439-r04y1j22	29	13	from	from	IN
cord-023439-r04y1j22	29	14	both	both	DT
cord-023439-r04y1j22	29	15	areas	area	NNS
cord-023439-r04y1j22	29	16	.	.	.
cord-023439-r04y1j22	30	1	mRNA	mRNA	NNP
cord-023439-r04y1j22	30	2	expression	expression	NN
cord-023439-r04y1j22	30	3	was	be	VBD
cord-023439-r04y1j22	30	4	evaluated	evaluate	VBN
cord-023439-r04y1j22	30	5	by	by	IN
cord-023439-r04y1j22	30	6	real	real	JJ
cord-023439-r04y1j22	30	7	-	-	HYPH
cord-023439-r04y1j22	30	8	time	time	NN
cord-023439-r04y1j22	30	9	PCR	PCR	NNP
cord-023439-r04y1j22	30	10	.	.	.
cord-023439-r04y1j22	31	1	LXR	LXR	NNP
cord-023439-r04y1j22	31	2	-	-	:
cord-023439-r04y1j22	31	3	a	a	NNP
cord-023439-r04y1j22	31	4	was	be	VBD
cord-023439-r04y1j22	31	5	lower	low	JJR
cord-023439-r04y1j22	32	1	(	(	-LRB-
cord-023439-r04y1j22	32	2	P	p	NN
cord-023439-r04y1j22	32	3	<	<	XX
cord-023439-r04y1j22	32	4	0.05	0.05	CD
cord-023439-r04y1j22	32	5	)	)	-RRB-
cord-023439-r04y1j22	32	6	in	in	IN
cord-023439-r04y1j22	32	7	MS	MS	NNP
cord-023439-r04y1j22	33	1	(	(	-LRB-
cord-023439-r04y1j22	33	2	mean	mean	VB
cord-023439-r04y1j22	33	3	AE	AE	NNP
cord-023439-r04y1j22	33	4	SEM	SEM	NNP
cord-023439-r04y1j22	33	5	:	:	:
cord-023439-r04y1j22	33	6	3.1	3.1	CD
cord-023439-r04y1j22	33	7	AE	AE	NNP
cord-023439-r04y1j22	33	8	0.2	0.2	CD
cord-023439-r04y1j22	33	9	;	;	:
cord-023439-r04y1j22	34	1	n	n	NNP
cord-023439-r04y1j22	34	2	¼	¼	NNP
cord-023439-r04y1j22	34	3	37	37	CD
cord-023439-r04y1j22	34	4	)	)	-RRB-
cord-023439-r04y1j22	34	5	compared	compare	VBN
cord-023439-r04y1j22	34	6	to	to	IN
cord-023439-r04y1j22	34	7	HC	HC	NNP
cord-023439-r04y1j22	34	8	(	(	-LRB-
cord-023439-r04y1j22	34	9	3.6	3.6	CD
cord-023439-r04y1j22	34	10	AE	AE	NNP
cord-023439-r04y1j22	34	11	0.1	0.1	CD
cord-023439-r04y1j22	34	12	;	;	:
cord-023439-r04y1j22	34	13	n	n	NN
cord-023439-r04y1j22	34	14	¼	¼	NNP
cord-023439-r04y1j22	34	15	37	37	CD
cord-023439-r04y1j22	34	16	)	)	-RRB-
cord-023439-r04y1j22	34	17	.	.	.
cord-023439-r04y1j22	35	1	LXR	LXR	NNP
cord-023439-r04y1j22	35	2	-	-	:
cord-023439-r04y1j22	35	3	a	a	NNP
cord-023439-r04y1j22	35	4	was	be	VBD
cord-023439-r04y1j22	35	5	lower	low	JJR
cord-023439-r04y1j22	35	6	in	in	IN
cord-023439-r04y1j22	35	7	MS	MS	NNP
cord-023439-r04y1j22	35	8	from	from	IN
cord-023439-r04y1j22	35	9	Stockholm	Stockholm	NNP
cord-023439-r04y1j22	35	10	(	(	-LRB-
cord-023439-r04y1j22	35	11	2.6	2.6	CD
cord-023439-r04y1j22	35	12	AE	AE	NNP
cord-023439-r04y1j22	35	13	0.2	0.2	CD
cord-023439-r04y1j22	35	14	;	;	:
cord-023439-r04y1j22	35	15	n	n	NN
cord-023439-r04y1j22	35	16	¼	¼	NNP
cord-023439-r04y1j22	35	17	22	22	CD
cord-023439-r04y1j22	35	18	)	)	-RRB-
cord-023439-r04y1j22	35	19	compared	compare	VBN
cord-023439-r04y1j22	35	20	to	to	IN
cord-023439-r04y1j22	35	21	corresponding	correspond	VBG
cord-023439-r04y1j22	35	22	HC	HC	NNP
cord-023439-r04y1j22	35	23	(	(	-LRB-
cord-023439-r04y1j22	35	24	3.4	3.4	CD
cord-023439-r04y1j22	35	25	AE	AE	NNP
cord-023439-r04y1j22	35	26	0.1	0.1	CD
cord-023439-r04y1j22	35	27	;	;	:
cord-023439-r04y1j22	35	28	n	n	NN
cord-023439-r04y1j22	35	29	¼	¼	NNP
cord-023439-r04y1j22	35	30	22	22	CD
cord-023439-r04y1j22	35	31	;	;	:
cord-023439-r04y1j22	35	32	P	p	NN
cord-023439-r04y1j22	35	33	<	<	XX
cord-023439-r04y1j22	35	34	0.01	0.01	CD
cord-023439-r04y1j22	35	35	)	)	-RRB-
cord-023439-r04y1j22	35	36	and	and	CC
cord-023439-r04y1j22	35	37	compared	compare	VBN
cord-023439-r04y1j22	35	38	to	to	IN
cord-023439-r04y1j22	35	39	MS	MS	NNP
cord-023439-r04y1j22	35	40	(	(	-LRB-
cord-023439-r04y1j22	35	41	3.8	3.8	CD
cord-023439-r04y1j22	35	42	AE	AE	NNP
cord-023439-r04y1j22	35	43	0.2	0.2	CD
cord-023439-r04y1j22	35	44	;	;	:
cord-023439-r04y1j22	35	45	n	n	NN
cord-023439-r04y1j22	35	46	¼	¼	NNP
cord-023439-r04y1j22	35	47	15	15	CD
cord-023439-r04y1j22	35	48	;	;	:
cord-023439-r04y1j22	35	49	P	p	NN
cord-023439-r04y1j22	35	50	<	<	XX
cord-023439-r04y1j22	35	51	0.001	0.001	CD
cord-023439-r04y1j22	35	52	)	)	-RRB-
cord-023439-r04y1j22	35	53	and	and	CC
cord-023439-r04y1j22	35	54	HC	HC	NNP
cord-023439-r04y1j22	35	55	(	(	-LRB-
cord-023439-r04y1j22	35	56	4	4	CD
cord-023439-r04y1j22	35	57	AE	AE	NNP
cord-023439-r04y1j22	35	58	0.2	0.2	CD
cord-023439-r04y1j22	35	59	;	;	:
cord-023439-r04y1j22	35	60	n	n	NN
cord-023439-r04y1j22	35	61	¼	¼	NNP
cord-023439-r04y1j22	35	62	15	15	CD
cord-023439-r04y1j22	35	63	;	;	:
cord-023439-r04y1j22	35	64	P	p	NN
cord-023439-r04y1j22	35	65	<	<	XX
cord-023439-r04y1j22	35	66	0.001	0.001	CD
cord-023439-r04y1j22	35	67	)	)	-RRB-
cord-023439-r04y1j22	35	68	from	from	IN
cord-023439-r04y1j22	35	69	Sardinia	Sardinia	NNP
cord-023439-r04y1j22	35	70	.	.	.
cord-023439-r04y1j22	36	1	MS	MS	NNP
cord-023439-r04y1j22	36	2	patients	patient	NNS
cord-023439-r04y1j22	36	3	from	from	IN
cord-023439-r04y1j22	36	4	Stockholm	Stockholm	NNP
cord-023439-r04y1j22	36	5	,	,	,
cord-023439-r04y1j22	36	6	but	but	CC
cord-023439-r04y1j22	36	7	not	not	RB
cord-023439-r04y1j22	36	8	from	from	IN
cord-023439-r04y1j22	36	9	Sassari	Sassari	NNP
cord-023439-r04y1j22	36	10	,	,	,
cord-023439-r04y1j22	36	11	also	also	RB
cord-023439-r04y1j22	36	12	expressed	express	VBD
cord-023439-r04y1j22	36	13	lower	low	JJR
cord-023439-r04y1j22	36	14	(	(	-LRB-
cord-023439-r04y1j22	36	15	P	p	NN
cord-023439-r04y1j22	36	16	<	<	XX
cord-023439-r04y1j22	36	17	0.05	0.05	CD
cord-023439-r04y1j22	36	18	)	)	-RRB-
cord-023439-r04y1j22	37	1	LXR	LXR	NNP
cord-023439-r04y1j22	37	2	-	-	HYPH
cord-023439-r04y1j22	37	3	b	b	NNP
cord-023439-r04y1j22	37	4	(	(	-LRB-
cord-023439-r04y1j22	37	5	À4.1	À4.1	NNP
cord-023439-r04y1j22	37	6	AE	AE	NNP
cord-023439-r04y1j22	37	7	0.4	0.4	CD
cord-023439-r04y1j22	37	8	)	)	-RRB-
cord-023439-r04y1j22	38	1	compared	compare	VBN
cord-023439-r04y1j22	38	2	to	to	IN
cord-023439-r04y1j22	38	3	corresponding	correspond	VBG
cord-023439-r04y1j22	38	4	HC	HC	NNP
cord-023439-r04y1j22	38	5	(	(	-LRB-
cord-023439-r04y1j22	38	6	À2.9	À2.9	NNP
cord-023439-r04y1j22	38	7	AE	AE	NNP
cord-023439-r04y1j22	38	8	0.3	0.3	CD
cord-023439-r04y1j22	38	9	)	)	-RRB-
cord-023439-r04y1j22	38	10	.	.	.
cord-023439-r04y1j22	39	1	MS	MS	NNP
cord-023439-r04y1j22	39	2	from	from	IN
cord-023439-r04y1j22	39	3	Stockholm	Stockholm	NNP
cord-023439-r04y1j22	39	4	was	be	VBD
cord-023439-r04y1j22	39	5	associated	associate	VBN
cord-023439-r04y1j22	39	6	with	with	IN
cord-023439-r04y1j22	39	7	higher	high	JJR
cord-023439-r04y1j22	39	8	ABCA-1	ABCA-1	NNP
cord-023439-r04y1j22	39	9	(	(	-LRB-
cord-023439-r04y1j22	39	10	6.1	6.1	CD
cord-023439-r04y1j22	39	11	AE	AE	NNP
cord-023439-r04y1j22	39	12	0.4	0.4	CD
cord-023439-r04y1j22	39	13	versus	versus	IN
cord-023439-r04y1j22	39	14	5.0	5.0	CD
cord-023439-r04y1j22	39	15	AE	AE	NNP
cord-023439-r04y1j22	39	16	0.3	0.3	CD
cord-023439-r04y1j22	39	17	;	;	:
cord-023439-r04y1j22	39	18	P	p	NN
cord-023439-r04y1j22	39	19	<	<	XX
cord-023439-r04y1j22	39	20	0.05	0.05	CD
cord-023439-r04y1j22	39	21	)	)	-RRB-
cord-023439-r04y1j22	39	22	and	and	CC
cord-023439-r04y1j22	39	23	higher	high	JJR
cord-023439-r04y1j22	39	24	estrogen	estrogen	NN
cord-023439-r04y1j22	39	25	receptor	receptor	NN
cord-023439-r04y1j22	39	26	-	-	HYPH
cord-023439-r04y1j22	39	27	b	b	NN
cord-023439-r04y1j22	39	28	-	-	HYPH
cord-023439-r04y1j22	39	29	Cx	cx	NN
cord-023439-r04y1j22	39	30	(	(	-LRB-
cord-023439-r04y1j22	39	31	2.4	2.4	CD
cord-023439-r04y1j22	39	32	AE	AE	NNP
cord-023439-r04y1j22	39	33	0.4	0.4	CD
cord-023439-r04y1j22	39	34	versus	versus	IN
cord-023439-r04y1j22	39	35	0.8	0.8	CD
cord-023439-r04y1j22	39	36	AE	AE	NNP
cord-023439-r04y1j22	39	37	0.4	0.4	CD
cord-023439-r04y1j22	39	38	;	;	:
cord-023439-r04y1j22	39	39	P	p	NN
cord-023439-r04y1j22	39	40	<	<	XX
cord-023439-r04y1j22	39	41	0.01	0.01	CD
cord-023439-r04y1j22	39	42	)	)	-RRB-
cord-023439-r04y1j22	39	43	compared	compare	VBN
cord-023439-r04y1j22	39	44	to	to	IN
cord-023439-r04y1j22	39	45	corresponding	correspond	VBG
cord-023439-r04y1j22	39	46	HC	HC	NNP
cord-023439-r04y1j22	39	47	.	.	.
cord-023439-r04y1j22	40	1	The	the	DT
cord-023439-r04y1j22	40	2	HC	HC	NNP
cord-023439-r04y1j22	40	3	from	from	IN
cord-023439-r04y1j22	40	4	Sassari	Sassari	NNP
cord-023439-r04y1j22	40	5	had	have	VBD
cord-023439-r04y1j22	40	6	higher	high	JJR
cord-023439-r04y1j22	40	7	androgen	androgen	NN
cord-023439-r04y1j22	40	8	receptor	receptor	NN
cord-023439-r04y1j22	40	9	(	(	-LRB-
cord-023439-r04y1j22	40	10	2.9	2.9	CD
cord-023439-r04y1j22	40	11	AE	AE	NNP
cord-023439-r04y1j22	40	12	0.2	0.2	CD
cord-023439-r04y1j22	40	13	)	)	-RRB-
cord-023439-r04y1j22	40	14	compared	compare	VBN
cord-023439-r04y1j22	40	15	to	to	IN
cord-023439-r04y1j22	40	16	MS	MS	NNP
cord-023439-r04y1j22	40	17	from	from	IN
cord-023439-r04y1j22	40	18	Sassari	Sassari	NNP
cord-023439-r04y1j22	40	19	(	(	-LRB-
cord-023439-r04y1j22	40	20	1.4	1.4	CD
cord-023439-r04y1j22	40	21	AE	AE	NNP
cord-023439-r04y1j22	40	22	0.3	0.3	CD
cord-023439-r04y1j22	40	23	;	;	:
cord-023439-r04y1j22	40	24	P	p	NN
cord-023439-r04y1j22	40	25	<	<	XX
cord-023439-r04y1j22	40	26	0.01	0.01	CD
cord-023439-r04y1j22	40	27	)	)	-RRB-
cord-023439-r04y1j22	40	28	,	,	,
cord-023439-r04y1j22	40	29	MS	MS	NNP
cord-023439-r04y1j22	40	30	(	(	-LRB-
cord-023439-r04y1j22	40	31	1.3	1.3	CD
cord-023439-r04y1j22	40	32	AE	AE	NNP
cord-023439-r04y1j22	40	33	0.4	0.4	CD
cord-023439-r04y1j22	40	34	;	;	:
cord-023439-r04y1j22	40	35	P	p	NN
cord-023439-r04y1j22	40	36	<	<	XX
cord-023439-r04y1j22	40	37	0.01	0.01	CD
cord-023439-r04y1j22	40	38	)	)	-RRB-
cord-023439-r04y1j22	40	39	and	and	CC
cord-023439-r04y1j22	40	40	HC	HC	NNP
cord-023439-r04y1j22	40	41	from	from	IN
cord-023439-r04y1j22	40	42	Stockholm	Stockholm	NNP
cord-023439-r04y1j22	40	43	(	(	-LRB-
cord-023439-r04y1j22	40	44	1.2	1.2	CD
cord-023439-r04y1j22	40	45	AE	AE	NNP
cord-023439-r04y1j22	40	46	0.3	0.3	CD
cord-023439-r04y1j22	40	47	;	;	:
cord-023439-r04y1j22	40	48	P	p	NN
cord-023439-r04y1j22	40	49	<	<	XX
cord-023439-r04y1j22	40	50	0.01	0.01	CD
cord-023439-r04y1j22	40	51	)	)	-RRB-
cord-023439-r04y1j22	40	52	.	.	.
cord-023439-r04y1j22	41	1	MS	MS	NNP
cord-023439-r04y1j22	41	2	from	from	IN
cord-023439-r04y1j22	41	3	Sassari	Sassari	NNP
cord-023439-r04y1j22	41	4	had	have	VBD
cord-023439-r04y1j22	41	5	lower	low	JJR
cord-023439-r04y1j22	41	6	cyclooxygenase-1	cyclooxygenase-1	NN
cord-023439-r04y1j22	41	7	compared	compare	VBN
cord-023439-r04y1j22	41	8	to	to	IN
cord-023439-r04y1j22	41	9	corresponding	correspond	VBG
cord-023439-r04y1j22	41	10	HC	HC	NNP
cord-023439-r04y1j22	41	11	(	(	-LRB-
cord-023439-r04y1j22	41	12	5.1	5.1	CD
cord-023439-r04y1j22	41	13	AE	AE	NNP
cord-023439-r04y1j22	41	14	0.4	0.4	CD
cord-023439-r04y1j22	41	15	versus	versus	IN
cord-023439-r04y1j22	41	16	6.6	6.6	CD
cord-023439-r04y1j22	41	17	AE	AE	NNP
cord-023439-r04y1j22	41	18	0.3	0.3	CD
cord-023439-r04y1j22	41	19	;	;	:
cord-023439-r04y1j22	41	20	P	p	NN
cord-023439-r04y1j22	41	21	<	<	XX
cord-023439-r04y1j22	41	22	0.01	0.01	CD
cord-023439-r04y1j22	41	23	)	)	-RRB-
cord-023439-r04y1j22	41	24	and	and	CC
cord-023439-r04y1j22	41	25	lower	low	JJR
cord-023439-r04y1j22	41	26	prostaglandin	prostaglandin	NN
cord-023439-r04y1j22	41	27	-	-	HYPH
cord-023439-r04y1j22	41	28	E	e	NN
cord-023439-r04y1j22	41	29	(	(	-LRB-
cord-023439-r04y1j22	41	30	À0.03	À0.03	NNP
cord-023439-r04y1j22	41	31	AE	AE	NNP
cord-023439-r04y1j22	41	32	0.5	0.5	CD
cord-023439-r04y1j22	41	33	)	)	-RRB-
cord-023439-r04y1j22	41	34	compared	compare	VBN
cord-023439-r04y1j22	41	35	to	to	IN
cord-023439-r04y1j22	41	36	the	the	DT
cord-023439-r04y1j22	41	37	HC	HC	NNP
cord-023439-r04y1j22	41	38	(	(	-LRB-
cord-023439-r04y1j22	41	39	1.4	1.4	CD
cord-023439-r04y1j22	41	40	AE	AE	NNP
cord-023439-r04y1j22	41	41	0.5	0.5	CD
cord-023439-r04y1j22	41	42	;	;	:
cord-023439-r04y1j22	41	43	P	p	NN
cord-023439-r04y1j22	41	44	<	<	XX
cord-023439-r04y1j22	41	45	0.05	0.05	CD
cord-023439-r04y1j22	41	46	)	)	-RRB-
cord-023439-r04y1j22	41	47	and	and	CC
cord-023439-r04y1j22	41	48	MS	MS	NNP
cord-023439-r04y1j22	41	49	(	(	-LRB-
cord-023439-r04y1j22	41	50	2.7	2.7	CD
cord-023439-r04y1j22	41	51	AE	AE	NNP
cord-023439-r04y1j22	41	52	0.4	0.4	CD
cord-023439-r04y1j22	41	53	;	;	:
cord-023439-r04y1j22	41	54	P	p	NN
cord-023439-r04y1j22	41	55	<	<	XX
cord-023439-r04y1j22	41	56	0.05	0.05	CD
cord-023439-r04y1j22	41	57	)	)	-RRB-
cord-023439-r04y1j22	41	58	and	and	CC
cord-023439-r04y1j22	41	59	HC	HC	NNP
cord-023439-r04y1j22	41	60	from	from	IN
cord-023439-r04y1j22	41	61	Stockholm	Stockholm	NNP
cord-023439-r04y1j22	41	62	(	(	-LRB-
cord-023439-r04y1j22	41	63	1.9	1.9	CD
cord-023439-r04y1j22	41	64	AE	AE	NNP
cord-023439-r04y1j22	41	65	0.4	0.4	CD
cord-023439-r04y1j22	41	66	,	,	,
cord-023439-r04y1j22	41	67	P	p	NN
cord-023439-r04y1j22	41	68	<	<	XX
cord-023439-r04y1j22	41	69	0.001	0.001	CD
cord-023439-r04y1j22	41	70	)	)	-RRB-
cord-023439-r04y1j22	41	71	.	.	.
cord-023439-r04y1j22	42	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	42	2	findings	finding	NNS
cord-023439-r04y1j22	42	3	identify	identify	VBP
cord-023439-r04y1j22	42	4	LXRs	lxr	NNS
cord-023439-r04y1j22	42	5	and	and	CC
cord-023439-r04y1j22	42	6	their	-PRON-	PRP$
cord-023439-r04y1j22	42	7	related	related	JJ
cord-023439-r04y1j22	42	8	molecules	molecule	NNS
cord-023439-r04y1j22	42	9	as	as	IN
cord-023439-r04y1j22	42	10	being	be	VBG
cord-023439-r04y1j22	42	11	involved	involve	VBN
cord-023439-r04y1j22	42	12	in	in	IN
cord-023439-r04y1j22	42	13	MS	MS	NNP
cord-023439-r04y1j22	42	14	from	from	IN
cord-023439-r04y1j22	42	15	Stockholm	Stockholm	NNP
cord-023439-r04y1j22	42	16	but	but	CC
cord-023439-r04y1j22	42	17	not	not	RB
cord-023439-r04y1j22	42	18	from	from	IN
cord-023439-r04y1j22	42	19	Sassari	Sassari	NNP
cord-023439-r04y1j22	42	20	,	,	,
cord-023439-r04y1j22	42	21	while	while	IN
cord-023439-r04y1j22	42	22	sex	sex	NN
cord-023439-r04y1j22	42	23	hormone	hormone	NN
cord-023439-r04y1j22	42	24	receptors	receptor	NNS
cord-023439-r04y1j22	42	25	seem	seem	VBP
cord-023439-r04y1j22	42	26	to	to	TO
cord-023439-r04y1j22	42	27	be	be	VB
cord-023439-r04y1j22	42	28	involved	involve	VBN
cord-023439-r04y1j22	42	29	in	in	IN
cord-023439-r04y1j22	42	30	MS	MS	NNP
cord-023439-r04y1j22	42	31	in	in	IN
cord-023439-r04y1j22	42	32	Sassari	Sassari	NNP
cord-023439-r04y1j22	42	33	.	.	.
cord-023439-r04y1j22	43	1	Multiple	multiple	JJ
cord-023439-r04y1j22	43	2	Sclerosis	Sclerosis	NNP
cord-023439-r04y1j22	43	3	:	:	:
cord-023439-r04y1j22	43	4	IFN	IFN	NNP
cord-023439-r04y1j22	43	5	-	-	HYPH
cord-023439-r04y1j22	43	6	b	b	NNP
cord-023439-r04y1j22	43	7	Induces	induce	VBZ
cord-023439-r04y1j22	44	1	CD123	CD123	NNP
cord-023439-r04y1j22	44	2	+	+	CC
cord-023439-r04y1j22	45	1	BDCA2	BDCA2	NNP
cord-023439-r04y1j22	45	2	-Dendritic	-Dendritic	NNP
cord-023439-r04y1j22	46	1	Cells	cell	NNS
cord-023439-r04y1j22	47	1	that	that	DT
cord-023439-r04y1j22	47	2	Produce	Produce	NNP
cord-023439-r04y1j22	47	3	IL-6	IL-6	NNP
cord-023439-r04y1j22	47	4	and	and	CC
cord-023439-r04y1j22	47	5	IL-10	IL-10	NNP
cord-023439-r04y1j22	47	6	and	and	CC
cord-023439-r04y1j22	47	7	have	have	VBP
cord-023439-r04y1j22	47	8	No	no	DT
cord-023439-r04y1j22	47	9	Enhanced	Enhanced	NNP
cord-023439-r04y1j22	47	10	Type	type	NN
cord-023439-r04y1j22	48	1	I	-PRON-	PRP
cord-023439-r04y1j22	49	1	Interferon	Interferon	NNP
cord-023439-r04y1j22	49	2	Production	Production	NNP
cord-023439-r04y1j22	49	3	Y.	Y.	NNP
cord-023439-r04y1j22	49	4	M.	M.	NNP
cord-023439-r04y1j22	49	5	Huang	Huang	NNP
cord-023439-r04y1j22	49	6	,	,	,
cord-023439-r04y1j22	49	7	1	1	CD
cord-023439-r04y1j22	49	8	S.	S.	NNP
cord-023439-r04y1j22	49	9	Adikari	Adikari	NNP
cord-023439-r04y1j22	49	10	,	,	,
cord-023439-r04y1j22	49	11	1	1	CD
cord-023439-r04y1j22	49	12	U.	U.	NNP
cord-023439-r04y1j22	49	13	Båve	Båve	NNP
cord-023439-r04y1j22	49	14	,	,	,
cord-023439-r04y1j22	49	15	2	2	CD
cord-023439-r04y1j22	49	16	A.	a.	NN
cord-023439-r04y1j22	49	17	Sanna	Sanna	NNP
cord-023439-r04y1j22	49	18	1,3	1,3	CD
cord-023439-r04y1j22	49	19	&	&	CC
cord-023439-r04y1j22	49	20	G.	G.	NNP
cord-023439-r04y1j22	49	21	Alm	Alm	NNP
cord-023439-r04y1j22	49	22	4	4	CD
cord-023439-r04y1j22	49	23	DC	DC	NNP
cord-023439-r04y1j22	49	24	antigens	antigen	NNS
cord-023439-r04y1j22	49	25	(	(	-LRB-
cord-023439-r04y1j22	49	26	BDCA	BDCA	NNP
cord-023439-r04y1j22	49	27	)	)	-RRB-
cord-023439-r04y1j22	49	28	and	and	CC
cord-023439-r04y1j22	49	29	investigate	investigate	VB
cord-023439-r04y1j22	49	30	their	-PRON-	PRP$
cord-023439-r04y1j22	49	31	ability	ability	NN
cord-023439-r04y1j22	49	32	to	to	TO
cord-023439-r04y1j22	49	33	produce	produce	VB
cord-023439-r04y1j22	49	34	Type	type	NN
cord-023439-r04y1j22	49	35	I	-PRON-	PRP
cord-023439-r04y1j22	49	36	IFN	IFN	NNP
cord-023439-r04y1j22	49	37	in	in	IN
cord-023439-r04y1j22	49	38	response	response	NN
cord-023439-r04y1j22	49	39	to	to	IN
cord-023439-r04y1j22	49	40	virus	virus	NN
cord-023439-r04y1j22	49	41	stimulation	stimulation	NN
cord-023439-r04y1j22	49	42	.	.	.
cord-023439-r04y1j22	50	1	We	-PRON-	PRP
cord-023439-r04y1j22	50	2	show	show	VBP
cord-023439-r04y1j22	50	3	that	that	IN
cord-023439-r04y1j22	50	4	IFN	IFN	NNP
cord-023439-r04y1j22	50	5	-	-	HYPH
cord-023439-r04y1j22	50	6	b	b	NNP
cord-023439-r04y1j22	50	7	induces	induce	VBZ
cord-023439-r04y1j22	50	8	development	development	NN
cord-023439-r04y1j22	50	9	of	of	IN
cord-023439-r04y1j22	50	10	CD123	CD123	NNP
cord-023439-r04y1j22	50	11	þ	þ	NNP
cord-023439-r04y1j22	50	12	DC	DC	NNP
cord-023439-r04y1j22	50	13	from	from	IN
cord-023439-r04y1j22	50	14	human	human	JJ
cord-023439-r04y1j22	50	15	blood	blood	NN
cord-023439-r04y1j22	50	16	monocytes	monocyte	NNS
cord-023439-r04y1j22	50	17	,	,	,
cord-023439-r04y1j22	50	18	which	which	WDT
cord-023439-r04y1j22	50	19	coexpress	coexpress	VBP
cord-023439-r04y1j22	50	20	BDCA4	bdca4	CC
cord-023439-r04y1j22	50	21	þ	þ	NNP
cord-023439-r04y1j22	50	22	but	but	CC
cord-023439-r04y1j22	50	23	are	be	VBP
cord-023439-r04y1j22	50	24	negative	negative	JJ
cord-023439-r04y1j22	50	25	for	for	IN
cord-023439-r04y1j22	50	26	BDCA2	BDCA2	NNP
cord-023439-r04y1j22	50	27	-	-	HYPH
cord-023439-r04y1j22	50	28	,	,	,
cord-023439-r04y1j22	50	29	a	a	DT
cord-023439-r04y1j22	50	30	specific	specific	JJ
cord-023439-r04y1j22	50	31	marker	marker	NN
cord-023439-r04y1j22	50	32	for	for	IN
cord-023439-r04y1j22	50	33	plasmacytoid	plasmacytoid	NNP
cord-023439-r04y1j22	50	34	DC	DC	NNP
cord-023439-r04y1j22	50	35	.	.	.
cord-023439-r04y1j22	51	1	Such	such	JJ
cord-023439-r04y1j22	51	2	IFN	IFN	NNP
cord-023439-r04y1j22	51	3	-	-	HYPH
cord-023439-r04y1j22	51	4	b	b	NNP
cord-023439-r04y1j22	51	5	-	-	HYPH
cord-023439-r04y1j22	51	6	modulated	modulate	VBN
cord-023439-r04y1j22	51	7	DC	DC	NNP
cord-023439-r04y1j22	51	8	produce	produce	VB
cord-023439-r04y1j22	51	9	large	large	JJ
cord-023439-r04y1j22	51	10	amounts	amount	NNS
cord-023439-r04y1j22	51	11	of	of	IN
cord-023439-r04y1j22	51	12	IL-6	IL-6	NNP
cord-023439-r04y1j22	51	13	and	and	CC
cord-023439-r04y1j22	51	14	IL-10	IL-10	NNP
cord-023439-r04y1j22	51	15	,	,	,
cord-023439-r04y1j22	51	16	but	but	CC
cord-023439-r04y1j22	51	17	no	no	DT
cord-023439-r04y1j22	51	18	IL-12p40	IL-12p40	NNP
cord-023439-r04y1j22	51	19	and	and	CC
cord-023439-r04y1j22	51	20	have	have	VBP
cord-023439-r04y1j22	51	21	no	no	DT
cord-023439-r04y1j22	51	22	enhanced	enhance	VBN
cord-023439-r04y1j22	51	23	IFN	IFN	NNP
cord-023439-r04y1j22	51	24	-	-	HYPH
cord-023439-r04y1j22	51	25	b	b	NNP
cord-023439-r04y1j22	51	26	and	and	CC
cord-023439-r04y1j22	51	27	IFN	IFN	NNP
cord-023439-r04y1j22	51	28	-	-	HYPH
cord-023439-r04y1j22	51	29	b	b	NN
cord-023439-r04y1j22	51	30	production	production	NN
cord-023439-r04y1j22	51	31	.	.	.
cord-023439-r04y1j22	52	1	The	the	DT
cord-023439-r04y1j22	52	2	findings	finding	NNS
cord-023439-r04y1j22	52	3	indicate	indicate	VBP
cord-023439-r04y1j22	52	4	that	that	IN
cord-023439-r04y1j22	52	5	IFN	IFN	NNP
cord-023439-r04y1j22	52	6	-	-	HYPH
cord-023439-r04y1j22	52	7	bmodulated	bmodulate	VBN
cord-023439-r04y1j22	52	8	DC	DC	NNP
cord-023439-r04y1j22	52	9	represent	represent	VBP
cord-023439-r04y1j22	52	10	a	a	DT
cord-023439-r04y1j22	52	11	myeloid	myeloid	JJ
cord-023439-r04y1j22	52	12	DC	DC	NNP
cord-023439-r04y1j22	52	13	subset	subset	VBN
cord-023439-r04y1j22	52	14	with	with	IN
cord-023439-r04y1j22	52	15	diminished	diminished	JJ
cord-023439-r04y1j22	52	16	CD11c	CD11c	NNP
cord-023439-r04y1j22	52	17	,	,	,
cord-023439-r04y1j22	52	18	BDCA-1	BDCA-1	NNP
cord-023439-r04y1j22	52	19	and	and	CC
cord-023439-r04y1j22	52	20	CD1a	CD1a	NNP
cord-023439-r04y1j22	52	21	expression	expression	NN
cord-023439-r04y1j22	52	22	,	,	,
cord-023439-r04y1j22	52	23	having	have	VBG
cord-023439-r04y1j22	52	24	potent	potent	JJ
cord-023439-r04y1j22	52	25	Th2-promoting	th2-promoting	CD
cord-023439-r04y1j22	52	26	function	function	NN
cord-023439-r04y1j22	52	27	but	but	CC
cord-023439-r04y1j22	52	28	lacking	lack	VBG
cord-023439-r04y1j22	52	29	antiviral	antiviral	JJ
cord-023439-r04y1j22	52	30	capacity	capacity	NN
cord-023439-r04y1j22	52	31	.	.	.
cord-023439-r04y1j22	53	1	The	the	DT
cord-023439-r04y1j22	53	2	association	association	NN
cord-023439-r04y1j22	53	3	of	of	IN
cord-023439-r04y1j22	53	4	psoriasis	psoriasis	NNP
cord-023439-r04y1j22	53	5	with	with	IN
cord-023439-r04y1j22	53	6	throat	throat	NN
cord-023439-r04y1j22	53	7	infections	infection	NNS
cord-023439-r04y1j22	53	8	by	by	IN
cord-023439-r04y1j22	53	9	streptococcus	streptococcus	NN
cord-023439-r04y1j22	53	10	pyogenes	pyogene	NNS
cord-023439-r04y1j22	53	11	suggests	suggest	VBZ
cord-023439-r04y1j22	53	12	a	a	DT
cord-023439-r04y1j22	53	13	potential	potential	JJ
cord-023439-r04y1j22	53	14	antigenic	antigenic	JJ
cord-023439-r04y1j22	53	15	target	target	NN
cord-023439-r04y1j22	53	16	for	for	IN
cord-023439-r04y1j22	53	17	the	the	DT
cord-023439-r04y1j22	53	18	T	t	NN
cord-023439-r04y1j22	53	19	cells	cell	NNS
cord-023439-r04y1j22	53	20	that	that	WDT
cord-023439-r04y1j22	53	21	are	be	VBP
cord-023439-r04y1j22	53	22	known	know	VBN
cord-023439-r04y1j22	53	23	to	to	TO
cord-023439-r04y1j22	53	24	infiltrate	infiltrate	VB
cord-023439-r04y1j22	53	25	dermis	dermis	NN
cord-023439-r04y1j22	53	26	and	and	CC
cord-023439-r04y1j22	53	27	epidermis	epidermis	NN
cord-023439-r04y1j22	53	28	of	of	IN
cord-023439-r04y1j22	53	29	psoriatic	psoriatic	JJ
cord-023439-r04y1j22	53	30	skin	skin	NN
cord-023439-r04y1j22	53	31	.	.	.
cord-023439-r04y1j22	54	1	Streptococcal	Streptococcal	NNP
cord-023439-r04y1j22	54	2	M	M	NNP
cord-023439-r04y1j22	54	3	protein	protein	NN
cord-023439-r04y1j22	54	4	shares	share	VBZ
cord-023439-r04y1j22	54	5	an	an	DT
cord-023439-r04y1j22	54	6	extensive	extensive	JJ
cord-023439-r04y1j22	54	7	sequence	sequence	NN
cord-023439-r04y1j22	54	8	homology	homology	NN
cord-023439-r04y1j22	54	9	with	with	IN
cord-023439-r04y1j22	54	10	human	human	JJ
cord-023439-r04y1j22	54	11	epidermal	epidermal	JJ
cord-023439-r04y1j22	54	12	keratins	keratin	NNS
cord-023439-r04y1j22	54	13	.	.	.
cord-023439-r04y1j22	55	1	Keratins	keratin	NNS
cord-023439-r04y1j22	55	2	16	16	CD
cord-023439-r04y1j22	55	3	(	(	-LRB-
cord-023439-r04y1j22	55	4	K16	K16	NNP
cord-023439-r04y1j22	55	5	)	)	-RRB-
cord-023439-r04y1j22	55	6	and	and	CC
cord-023439-r04y1j22	55	7	17	17	CD
cord-023439-r04y1j22	55	8	(	(	-LRB-
cord-023439-r04y1j22	55	9	K17	K17	NNP
cord-023439-r04y1j22	55	10	)	)	-RRB-
cord-023439-r04y1j22	55	11	are	be	VBP
cord-023439-r04y1j22	55	12	mostly	mostly	RB
cord-023439-r04y1j22	55	13	absent	absent	JJ
cord-023439-r04y1j22	55	14	from	from	IN
cord-023439-r04y1j22	55	15	uninvolved	uninvolved	JJ
cord-023439-r04y1j22	55	16	skin	skin	NN
cord-023439-r04y1j22	55	17	but	but	CC
cord-023439-r04y1j22	55	18	are	be	VBP
cord-023439-r04y1j22	55	19	upregulated	upregulate	VBN
cord-023439-r04y1j22	55	20	in	in	IN
cord-023439-r04y1j22	55	21	psoriatic	psoriatic	JJ
cord-023439-r04y1j22	55	22	lesions	lesion	NNS
cord-023439-r04y1j22	55	23	.	.	.
cord-023439-r04y1j22	56	1	There	there	EX
cord-023439-r04y1j22	56	2	is	be	VBZ
cord-023439-r04y1j22	56	3	increasing	increase	VBG
cord-023439-r04y1j22	56	4	evidence	evidence	NN
cord-023439-r04y1j22	56	5	that	that	IN
cord-023439-r04y1j22	56	6	CD8	CD8	NNP
cord-023439-r04y1j22	56	7	þ	þ	NNP
cord-023439-r04y1j22	56	8	T	T	NNP
cord-023439-r04y1j22	56	9	cells	cell	NNS
cord-023439-r04y1j22	56	10	play	play	VBP
cord-023439-r04y1j22	56	11	an	an	DT
cord-023439-r04y1j22	56	12	important	important	JJ
cord-023439-r04y1j22	56	13	effector	effector	NN
cord-023439-r04y1j22	56	14	role	role	NN
cord-023439-r04y1j22	56	15	in	in	IN
cord-023439-r04y1j22	56	16	psoriasis	psoriasis	NN
cord-023439-r04y1j22	56	17	and	and	CC
cord-023439-r04y1j22	56	18	M	M	NNP
cord-023439-r04y1j22	56	19	proteinprimed	proteinprimed	NNP
cord-023439-r04y1j22	56	20	T	T	NNP
cord-023439-r04y1j22	56	21	cells	cell	NNS
cord-023439-r04y1j22	56	22	may	may	MD
cord-023439-r04y1j22	56	23	recognize	recognize	VB
cord-023439-r04y1j22	56	24	these	these	DT
cord-023439-r04y1j22	56	25	shared	share	VBN
cord-023439-r04y1j22	56	26	epitopes	epitope	NNS
cord-023439-r04y1j22	56	27	in	in	IN
cord-023439-r04y1j22	56	28	skin	skin	NN
cord-023439-r04y1j22	56	29	via	via	IN
cord-023439-r04y1j22	56	30	molecular	molecular	JJ
cord-023439-r04y1j22	56	31	mimicry	mimicry	NN
cord-023439-r04y1j22	56	32	.	.	.
cord-023439-r04y1j22	57	1	To	to	TO
cord-023439-r04y1j22	57	2	identify	identify	VB
cord-023439-r04y1j22	57	3	candidate	candidate	NN
cord-023439-r04y1j22	57	4	epitopes	epitope	NNS
cord-023439-r04y1j22	57	5	,	,	,
cord-023439-r04y1j22	57	6	peptides	peptide	NNS
cord-023439-r04y1j22	57	7	with	with	IN
cord-023439-r04y1j22	57	8	sequences	sequence	NNS
cord-023439-r04y1j22	57	9	from	from	IN
cord-023439-r04y1j22	57	10	K17	K17	NNP
cord-023439-r04y1j22	57	11	were	be	VBD
cord-023439-r04y1j22	57	12	selected	select	VBN
cord-023439-r04y1j22	57	13	on	on	IN
cord-023439-r04y1j22	57	14	the	the	DT
cord-023439-r04y1j22	57	15	basis	basis	NN
cord-023439-r04y1j22	57	16	of	of	IN
cord-023439-r04y1j22	57	17	predicted	predict	VBN
cord-023439-r04y1j22	57	18	binding	bind	VBG
cord-023439-r04y1j22	57	19	to	to	IN
cord-023439-r04y1j22	57	20	HLA	HLA	NNP
cord-023439-r04y1j22	57	21	-	-	HYPH
cord-023439-r04y1j22	57	22	Cw6	cw6	NN
cord-023439-r04y1j22	57	23	and	and	CC
cord-023439-r04y1j22	57	24	sequence	sequence	NN
cord-023439-r04y1j22	57	25	similarities	similarity	NNS
cord-023439-r04y1j22	57	26	with	with	IN
cord-023439-r04y1j22	57	27	M6	m6	JJ
cord-023439-r04y1j22	57	28	protein	protein	NN
cord-023439-r04y1j22	57	29	.	.	.
cord-023439-r04y1j22	58	1	Matched	match	VBN
cord-023439-r04y1j22	58	2	peptides	peptide	NNS
cord-023439-r04y1j22	58	3	from	from	IN
cord-023439-r04y1j22	58	4	the	the	DT
cord-023439-r04y1j22	58	5	sequence	sequence	NN
cord-023439-r04y1j22	58	6	of	of	IN
cord-023439-r04y1j22	58	7	M6	m6	JJ
cord-023439-r04y1j22	58	8	protein	protein	NN
cord-023439-r04y1j22	58	9	and	and	CC
cord-023439-r04y1j22	58	10	a	a	DT
cord-023439-r04y1j22	58	11	set	set	NN
cord-023439-r04y1j22	58	12	of	of	IN
cord-023439-r04y1j22	58	13	peptides	peptide	NNS
cord-023439-r04y1j22	58	14	with	with	IN
cord-023439-r04y1j22	58	15	poor	poor	JJ
cord-023439-r04y1j22	58	16	predicted	predict	VBN
cord-023439-r04y1j22	58	17	binding	binding	NN
cord-023439-r04y1j22	58	18	were	be	VBD
cord-023439-r04y1j22	58	19	also	also	RB
cord-023439-r04y1j22	58	20	selected	select	VBN
cord-023439-r04y1j22	58	21	.	.	.
cord-023439-r04y1j22	59	1	Cw6	Cw6	NNP
cord-023439-r04y1j22	59	2	þ	þ	NNP
cord-023439-r04y1j22	59	3	individuals	individual	NNS
cord-023439-r04y1j22	59	4	with	with	IN
cord-023439-r04y1j22	59	5	psoriasis	psoriasis	NN
cord-023439-r04y1j22	59	6	and	and	CC
cord-023439-r04y1j22	59	7	Cw6	cw6	VBP
cord-023439-r04y1j22	59	8	þ	þ	NNP
cord-023439-r04y1j22	59	9	healthy	healthy	JJ
cord-023439-r04y1j22	59	10	controls	control	NNS
cord-023439-r04y1j22	59	11	,	,	,
cord-023439-r04y1j22	59	12	having	have	VBG
cord-023439-r04y1j22	59	13	a	a	DT
cord-023439-r04y1j22	59	14	family	family	NN
cord-023439-r04y1j22	59	15	history	history	NN
cord-023439-r04y1j22	59	16	of	of	IN
cord-023439-r04y1j22	59	17	psoriasis	psoriasis	NN
cord-023439-r04y1j22	59	18	,	,	,
cord-023439-r04y1j22	59	19	were	be	VBD
cord-023439-r04y1j22	59	20	recruited	recruit	VBN
cord-023439-r04y1j22	59	21	.	.	.
cord-023439-r04y1j22	60	1	PBMCs	pbmc	NNS
cord-023439-r04y1j22	60	2	were	be	VBD
cord-023439-r04y1j22	60	3	incubated	incubate	VBN
cord-023439-r04y1j22	60	4	with	with	IN
cord-023439-r04y1j22	60	5	the	the	DT
cord-023439-r04y1j22	60	6	peptide	peptide	NN
cord-023439-r04y1j22	60	7	antigens	antigen	NNS
cord-023439-r04y1j22	60	8	.	.	.
cord-023439-r04y1j22	61	1	T	t	NN
cord-023439-r04y1j22	61	2	-	-	HYPH
cord-023439-r04y1j22	61	3	cell	cell	NN
cord-023439-r04y1j22	61	4	activation	activation	NN
cord-023439-r04y1j22	61	5	in	in	IN
cord-023439-r04y1j22	61	6	the	the	DT
cord-023439-r04y1j22	61	7	CD4	CD4	NNP
cord-023439-r04y1j22	61	8	þ	þ	NNP
cord-023439-r04y1j22	61	9	,	,	,
cord-023439-r04y1j22	61	10	CD8	CD8	NNP
cord-023439-r04y1j22	61	11	þ	þ	NNP
cord-023439-r04y1j22	61	12	and	and	CC
cord-023439-r04y1j22	61	13	later	later	RBR
cord-023439-r04y1j22	61	14	the	the	DT
cord-023439-r04y1j22	61	15	skin	skin	NN
cord-023439-r04y1j22	61	16	-	-	HYPH
cord-023439-r04y1j22	61	17	homing	home	VBG
cord-023439-r04y1j22	61	18	cutaneous	cutaneous	JJ
cord-023439-r04y1j22	61	19	lymphocyteassociated	lymphocyteassociated	JJ
cord-023439-r04y1j22	61	20	antigen	antigen	NN
cord-023439-r04y1j22	61	21	(	(	-LRB-
cord-023439-r04y1j22	61	22	CLA)-expressing	cla)-expresse	VBG
cord-023439-r04y1j22	61	23	subset	subset	NN
cord-023439-r04y1j22	61	24	of	of	IN
cord-023439-r04y1j22	61	25	CD8	CD8	NNP
cord-023439-r04y1j22	61	26	þ	þ	NNP
cord-023439-r04y1j22	61	27	T	T	NNP
cord-023439-r04y1j22	61	28	cells	cell	NNS
cord-023439-r04y1j22	61	29	was	be	VBD
cord-023439-r04y1j22	61	30	evaluated	evaluate	VBN
cord-023439-r04y1j22	61	31	by	by	IN
cord-023439-r04y1j22	61	32	CD69	CD69	NNP
cord-023439-r04y1j22	61	33	expression	expression	NN
cord-023439-r04y1j22	61	34	and	and	CC
cord-023439-r04y1j22	61	35	intracellular	intracellular	JJ
cord-023439-r04y1j22	61	36	IFN	IFN	NNP
cord-023439-r04y1j22	61	37	-	-	HYPH
cord-023439-r04y1j22	61	38	g	g	NN
cord-023439-r04y1j22	61	39	accumulation	accumulation	NN
cord-023439-r04y1j22	61	40	using	use	VBG
cord-023439-r04y1j22	61	41	flow	flow	NN
cord-023439-r04y1j22	61	42	cytometry	cytometry	NN
cord-023439-r04y1j22	61	43	.	.	.
cord-023439-r04y1j22	62	1	We	-PRON-	PRP
cord-023439-r04y1j22	62	2	demonstrate	demonstrate	VBP
cord-023439-r04y1j22	62	3	that	that	IN
cord-023439-r04y1j22	62	4	Cw6	cw6	NN
cord-023439-r04y1j22	62	5	þ	þ	CD
cord-023439-r04y1j22	62	6	psoriasis	psoriasis	NN
cord-023439-r04y1j22	62	7	patients	patient	NNS
cord-023439-r04y1j22	62	8	had	have	VBD
cord-023439-r04y1j22	62	9	significant	significant	JJ
cord-023439-r04y1j22	62	10	CD8	CD8	NNP
cord-023439-r04y1j22	62	11	þ	þ	NNP
cord-023439-r04y1j22	62	12	T	T	NNP
cord-023439-r04y1j22	62	13	-	-	HYPH
cord-023439-r04y1j22	62	14	cell	cell	NN
cord-023439-r04y1j22	62	15	IFN	IFN	NNP
cord-023439-r04y1j22	62	16	-	-	HYPH
cord-023439-r04y1j22	62	17	g	g	NNP
cord-023439-r04y1j22	62	18	responses	response	NNS
cord-023439-r04y1j22	62	19	to	to	IN
cord-023439-r04y1j22	62	20	peptides	peptide	NNS
cord-023439-r04y1j22	62	21	from	from	IN
cord-023439-r04y1j22	62	22	K17	K17	NNP
cord-023439-r04y1j22	62	23	and	and	CC
cord-023439-r04y1j22	62	24	M6	M6	NNP
cord-023439-r04y1j22	62	25	protein	protein	NN
cord-023439-r04y1j22	62	26	selected	select	VBN
cord-023439-r04y1j22	62	27	on	on	IN
cord-023439-r04y1j22	62	28	the	the	DT
cord-023439-r04y1j22	62	29	basis	basis	NN
cord-023439-r04y1j22	62	30	of	of	IN
cord-023439-r04y1j22	62	31	sequence	sequence	NN
cord-023439-r04y1j22	62	32	homology	homology	NN
cord-023439-r04y1j22	62	33	and	and	CC
cord-023439-r04y1j22	62	34	predicted	predict	VBD
cord-023439-r04y1j22	62	35	HLA	HLA	NNP
cord-023439-r04y1j22	62	36	-	-	HYPH
cord-023439-r04y1j22	62	37	Cw*0602	cw*0602	NN
cord-023439-r04y1j22	62	38	binding	binding	NN
cord-023439-r04y1j22	62	39	.	.	.
cord-023439-r04y1j22	63	1	These	these	DT
cord-023439-r04y1j22	63	2	responses	response	NNS
cord-023439-r04y1j22	63	3	were	be	VBD
cord-023439-r04y1j22	63	4	about	about	RB
cord-023439-r04y1j22	63	5	10	10	CD
cord-023439-r04y1j22	63	6	times	time	NNS
cord-023439-r04y1j22	63	7	more	more	RBR
cord-023439-r04y1j22	63	8	frequent	frequent	JJ
cord-023439-r04y1j22	63	9	in	in	IN
cord-023439-r04y1j22	63	10	the	the	DT
cord-023439-r04y1j22	63	11	skin	skin	NN
cord-023439-r04y1j22	63	12	-	-	HYPH
cord-023439-r04y1j22	63	13	homing	home	VBG
cord-023439-r04y1j22	63	14	cutaneous	cutaneous	JJ
cord-023439-r04y1j22	63	15	lymphocyte	lymphocyte	NN
cord-023439-r04y1j22	63	16	-	-	HYPH
cord-023439-r04y1j22	63	17	associated	associate	VBN
cord-023439-r04y1j22	63	18	antigen	antigen	NN
cord-023439-r04y1j22	63	19	-	-	HYPH
cord-023439-r04y1j22	63	20	expressing	express	VBG
cord-023439-r04y1j22	64	1	(	(	-LRB-
cord-023439-r04y1j22	64	2	CLA	CLA	NNP
cord-023439-r04y1j22	64	3	þ	þ	NNP
cord-023439-r04y1j22	64	4	)	)	-RRB-
cord-023439-r04y1j22	65	1	subset	subset	VBN
cord-023439-r04y1j22	65	2	of	of	IN
cord-023439-r04y1j22	65	3	CD8	CD8	NNP
cord-023439-r04y1j22	65	4	þ	þ	NNP
cord-023439-r04y1j22	65	5	T	T	NNP
cord-023439-r04y1j22	65	6	cells	cell	NNS
cord-023439-r04y1j22	65	7	.	.	.
cord-023439-r04y1j22	66	1	CD4	CD4	NNP
cord-023439-r04y1j22	66	2	þ	þ	NNP
cord-023439-r04y1j22	66	3	T	t	NN
cord-023439-r04y1j22	66	4	cells	cell	NNS
cord-023439-r04y1j22	66	5	showed	show	VBD
cord-023439-r04y1j22	66	6	only	only	RB
cord-023439-r04y1j22	66	7	borderline	borderline	JJ
cord-023439-r04y1j22	66	8	responses	response	NNS
cord-023439-r04y1j22	66	9	.	.	.
cord-023439-r04y1j22	67	1	CD8	CD8	NNP
cord-023439-r04y1j22	67	2	þ	þ	NNP
cord-023439-r04y1j22	67	3	T	T	NNP
cord-023439-r04y1j22	67	4	cells	cell	NNS
cord-023439-r04y1j22	67	5	from	from	IN
cord-023439-r04y1j22	67	6	Cw6	cw6	NN
cord-023439-r04y1j22	67	7	þ	þ	NNP
cord-023439-r04y1j22	67	8	nonpsoriatic	nonpsoriatic	JJ
cord-023439-r04y1j22	67	9	individuals	individual	NNS
cord-023439-r04y1j22	67	10	responded	respond	VBD
cord-023439-r04y1j22	67	11	to	to	IN
cord-023439-r04y1j22	67	12	some	some	DT
cord-023439-r04y1j22	67	13	M6	m6	JJ
cord-023439-r04y1j22	67	14	peptides	peptide	NNS
cord-023439-r04y1j22	67	15	but	but	CC
cord-023439-r04y1j22	67	16	very	very	RB
cord-023439-r04y1j22	67	17	rarely	rarely	RB
cord-023439-r04y1j22	67	18	to	to	IN
cord-023439-r04y1j22	67	19	K17	K17	NNP
cord-023439-r04y1j22	67	20	peptides	peptide	NNS
cord-023439-r04y1j22	67	21	,	,	,
cord-023439-r04y1j22	67	22	and	and	CC
cord-023439-r04y1j22	67	23	this	this	DT
cord-023439-r04y1j22	67	24	also	also	RB
cord-023439-r04y1j22	67	25	applied	apply	VBD
cord-023439-r04y1j22	67	26	to	to	IN
cord-023439-r04y1j22	67	27	the	the	DT
cord-023439-r04y1j22	67	28	CLA	CLA	NNP
cord-023439-r04y1j22	67	29	þ	þ	NNP
cord-023439-r04y1j22	67	30	CD8	CD8	NNP
cord-023439-r04y1j22	67	31	þ	þ	NNP
cord-023439-r04y1j22	67	32	subset	subset	JJ
cord-023439-r04y1j22	67	33	.	.	.
cord-023439-r04y1j22	68	1	These	these	DT
cord-023439-r04y1j22	68	2	findings	finding	NNS
cord-023439-r04y1j22	68	3	indicate	indicate	VBP
cord-023439-r04y1j22	68	4	that	that	IN
cord-023439-r04y1j22	68	5	psoriatic	psoriatic	JJ
cord-023439-r04y1j22	68	6	individuals	individual	NNS
cord-023439-r04y1j22	68	7	have	have	VBP
cord-023439-r04y1j22	68	8	CD8	CD8	NNP
cord-023439-r04y1j22	68	9	þ	þ	NNP
cord-023439-r04y1j22	68	10	T	T	NNP
cord-023439-r04y1j22	68	11	cells	cell	NNS
cord-023439-r04y1j22	68	12	that	that	WDT
cord-023439-r04y1j22	68	13	recognize	recognize	VBP
cord-023439-r04y1j22	68	14	keratin	keratin	NN
cord-023439-r04y1j22	68	15	self	self	NN
cord-023439-r04y1j22	68	16	-	-	HYPH
cord-023439-r04y1j22	68	17	antigens	antigen	NNS
cord-023439-r04y1j22	68	18	and	and	CC
cord-023439-r04y1j22	68	19	that	that	IN
cord-023439-r04y1j22	68	20	epitopes	epitope	NNS
cord-023439-r04y1j22	68	21	shared	share	VBN
cord-023439-r04y1j22	68	22	by	by	IN
cord-023439-r04y1j22	68	23	streptococcal	streptococcal	JJ
cord-023439-r04y1j22	68	24	M	M	NNP
cord-023439-r04y1j22	68	25	protein	protein	NN
cord-023439-r04y1j22	68	26	and	and	CC
cord-023439-r04y1j22	68	27	human	human	JJ
cord-023439-r04y1j22	68	28	keratin	keratin	NN
cord-023439-r04y1j22	68	29	may	may	MD
cord-023439-r04y1j22	68	30	be	be	VB
cord-023439-r04y1j22	68	31	targets	target	NNS
cord-023439-r04y1j22	68	32	for	for	IN
cord-023439-r04y1j22	68	33	the	the	DT
cord-023439-r04y1j22	68	34	CD8	CD8	NNP
cord-023439-r04y1j22	68	35	þ	þ	NNP
cord-023439-r04y1j22	68	36	T	T	NNP
cord-023439-r04y1j22	68	37	cells	cell	NNS
cord-023439-r04y1j22	68	38	that	that	WDT
cord-023439-r04y1j22	68	39	infiltrate	infiltrate	VBP
cord-023439-r04y1j22	68	40	psoriatic	psoriatic	JJ
cord-023439-r04y1j22	68	41	skin	skin	NN
cord-023439-r04y1j22	68	42	lesions	lesion	NNS
cord-023439-r04y1j22	68	43	.	.	.
cord-023439-r04y1j22	69	1	Autoantibodies	Autoantibodies	NNP
cord-023439-r04y1j22	69	2	directed	direct	VBN
cord-023439-r04y1j22	69	3	against	against	IN
cord-023439-r04y1j22	69	4	citrulline	citrulline	NN
cord-023439-r04y1j22	69	5	-	-	HYPH
cord-023439-r04y1j22	69	6	containing	contain	VBG
cord-023439-r04y1j22	69	7	proteins	protein	NNS
cord-023439-r04y1j22	69	8	have	have	VBP
cord-023439-r04y1j22	69	9	an	an	DT
cord-023439-r04y1j22	69	10	impressive	impressive	JJ
cord-023439-r04y1j22	69	11	specificity	specificity	NN
cord-023439-r04y1j22	69	12	of	of	IN
cord-023439-r04y1j22	69	13	nearly	nearly	RB
cord-023439-r04y1j22	69	14	100	100	CD
cord-023439-r04y1j22	69	15	%	%	NN
cord-023439-r04y1j22	69	16	in	in	IN
cord-023439-r04y1j22	69	17	RA	RA	NNP
cord-023439-r04y1j22	69	18	patients	patient	NNS
cord-023439-r04y1j22	69	19	and	and	CC
cord-023439-r04y1j22	69	20	a	a	DT
cord-023439-r04y1j22	69	21	suggestive	suggestive	JJ
cord-023439-r04y1j22	69	22	involvement	involvement	NN
cord-023439-r04y1j22	69	23	in	in	IN
cord-023439-r04y1j22	69	24	the	the	DT
cord-023439-r04y1j22	69	25	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	69	26	.	.	.
cord-023439-r04y1j22	70	1	The	the	DT
cord-023439-r04y1j22	70	2	targeted	target	VBN
cord-023439-r04y1j22	70	3	epitopes	epitope	NNS
cord-023439-r04y1j22	70	4	are	be	VBP
cord-023439-r04y1j22	70	5	generated	generate	VBN
cord-023439-r04y1j22	70	6	by	by	IN
cord-023439-r04y1j22	70	7	a	a	DT
cord-023439-r04y1j22	70	8	post	post	JJ
cord-023439-r04y1j22	70	9	-	-	JJ
cord-023439-r04y1j22	70	10	translational	translational	JJ
cord-023439-r04y1j22	70	11	modification	modification	NN
cord-023439-r04y1j22	70	12	catalysed	catalyse	VBN
cord-023439-r04y1j22	70	13	by	by	IN
cord-023439-r04y1j22	71	1	the	the	DT
cord-023439-r04y1j22	71	2	calcium	calcium	NN
cord-023439-r04y1j22	71	3	-	-	HYPH
cord-023439-r04y1j22	71	4	dependent	dependent	JJ
cord-023439-r04y1j22	71	5	enzyme	enzyme	NN
cord-023439-r04y1j22	71	6	peptidyl	peptidyl	NNP
cord-023439-r04y1j22	71	7	arginine	arginine	NN
cord-023439-r04y1j22	71	8	deaminase	deaminase	NNP
cord-023439-r04y1j22	71	9	that	that	WDT
cord-023439-r04y1j22	71	10	converts	convert	VBZ
cord-023439-r04y1j22	71	11	the	the	DT
cord-023439-r04y1j22	71	12	positively	positively	RB
cord-023439-r04y1j22	71	13	charged	charge	VBN
cord-023439-r04y1j22	71	14	arginine	arginine	NN
cord-023439-r04y1j22	71	15	to	to	IN
cord-023439-r04y1j22	71	16	polar	polar	JJ
cord-023439-r04y1j22	71	17	but	but	CC
cord-023439-r04y1j22	71	18	uncharged	uncharged	JJ
cord-023439-r04y1j22	71	19	citrullin	citrullin	NNP
cord-023439-r04y1j22	71	20	.	.	.
cord-023439-r04y1j22	72	1	The	the	DT
cord-023439-r04y1j22	72	2	aim	aim	NN
cord-023439-r04y1j22	72	3	of	of	IN
cord-023439-r04y1j22	72	4	this	this	DT
cord-023439-r04y1j22	72	5	study	study	NN
cord-023439-r04y1j22	72	6	was	be	VBD
cord-023439-r04y1j22	72	7	to	to	TO
cord-023439-r04y1j22	72	8	analyse	analyse	VB
cord-023439-r04y1j22	72	9	the	the	DT
cord-023439-r04y1j22	72	10	presence	presence	NN
cord-023439-r04y1j22	72	11	of	of	IN
cord-023439-r04y1j22	72	12	citrulline	citrulline	NN
cord-023439-r04y1j22	72	13	in	in	IN
cord-023439-r04y1j22	72	14	the	the	DT
cord-023439-r04y1j22	72	15	joints	joint	NNS
cord-023439-r04y1j22	72	16	at	at	IN
cord-023439-r04y1j22	72	17	different	different	JJ
cord-023439-r04y1j22	72	18	time	time	NN
cord-023439-r04y1j22	72	19	points	point	NNS
cord-023439-r04y1j22	72	20	of	of	IN
cord-023439-r04y1j22	72	21	collagen	collagen	NN
cord-023439-r04y1j22	72	22	-	-	HYPH
cord-023439-r04y1j22	72	23	induced	induce	VBN
cord-023439-r04y1j22	72	24	arthritis	arthritis	NN
cord-023439-r04y1j22	72	25	in	in	IN
cord-023439-r04y1j22	72	26	DA	DA	NNP
cord-023439-r04y1j22	72	27	rats	rat	NNS
cord-023439-r04y1j22	72	28	by	by	IN
cord-023439-r04y1j22	72	29	immunohistochemistry	immunohistochemistry	NN
cord-023439-r04y1j22	72	30	and	and	CC
cord-023439-r04y1j22	72	31	to	to	TO
cord-023439-r04y1j22	72	32	investigate	investigate	VB
cord-023439-r04y1j22	72	33	how	how	WRB
cord-023439-r04y1j22	72	34	immunogenicity	immunogenicity	NN
cord-023439-r04y1j22	72	35	and	and	CC
cord-023439-r04y1j22	72	36	arthritogenicity	arthritogenicity	NN
cord-023439-r04y1j22	72	37	was	be	VBD
cord-023439-r04y1j22	72	38	affected	affect	VBN
cord-023439-r04y1j22	72	39	by	by	IN
cord-023439-r04y1j22	72	40	citrullination	citrullination	NN
cord-023439-r04y1j22	72	41	of	of	IN
cord-023439-r04y1j22	72	42	rat	rat	NN
cord-023439-r04y1j22	72	43	serum	serum	NN
cord-023439-r04y1j22	72	44	albumin	albumin	NN
cord-023439-r04y1j22	72	45	(	(	-LRB-
cord-023439-r04y1j22	72	46	RSA	RSA	NNP
cord-023439-r04y1j22	72	47	)	)	-RRB-
cord-023439-r04y1j22	72	48	and	and	CC
cord-023439-r04y1j22	72	49	collagen	collagen	NN
cord-023439-r04y1j22	72	50	type	type	NN
cord-023439-r04y1j22	72	51	II	II	NNP
cord-023439-r04y1j22	72	52	(	(	-LRB-
cord-023439-r04y1j22	72	53	CII	CII	NNP
cord-023439-r04y1j22	72	54	)	)	-RRB-
cord-023439-r04y1j22	72	55	.	.	.
cord-023439-r04y1j22	73	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	73	2	results	result	NNS
cord-023439-r04y1j22	73	3	indicate	indicate	VBP
cord-023439-r04y1j22	73	4	that	that	IN
cord-023439-r04y1j22	73	5	citrulline	citrulline	NN
cord-023439-r04y1j22	73	6	could	could	MD
cord-023439-r04y1j22	73	7	be	be	VB
cord-023439-r04y1j22	73	8	detected	detect	VBN
cord-023439-r04y1j22	73	9	in	in	IN
cord-023439-r04y1j22	73	10	joints	joint	NNS
cord-023439-r04y1j22	73	11	of	of	IN
cord-023439-r04y1j22	73	12	arthritic	arthritic	JJ
cord-023439-r04y1j22	73	13	animals	animal	NNS
cord-023439-r04y1j22	73	14	,	,	,
cord-023439-r04y1j22	73	15	first	first	JJ
cord-023439-r04y1j22	73	16	appearance	appearance	NN
cord-023439-r04y1j22	73	17	at	at	IN
cord-023439-r04y1j22	73	18	the	the	DT
cord-023439-r04y1j22	73	19	onset	onset	NN
cord-023439-r04y1j22	73	20	of	of	IN
cord-023439-r04y1j22	73	21	disease	disease	NN
cord-023439-r04y1j22	73	22	and	and	CC
cord-023439-r04y1j22	73	23	increasing	increase	VBG
cord-023439-r04y1j22	73	24	as	as	IN
cord-023439-r04y1j22	73	25	disease	disease	NN
cord-023439-r04y1j22	73	26	progressed	progress	VBD
cord-023439-r04y1j22	73	27	into	into	IN
cord-023439-r04y1j22	73	28	a	a	DT
cord-023439-r04y1j22	73	29	chronic	chronic	JJ
cord-023439-r04y1j22	73	30	state	state	NN
cord-023439-r04y1j22	73	31	.	.	.
cord-023439-r04y1j22	74	1	Unimmunized	unimmunized	JJ
cord-023439-r04y1j22	74	2	animals	animal	NNS
cord-023439-r04y1j22	74	3	or	or	CC
cord-023439-r04y1j22	74	4	time	time	NN
cord-023439-r04y1j22	74	5	points	point	NNS
cord-023439-r04y1j22	74	6	before	before	IN
cord-023439-r04y1j22	74	7	clinical	clinical	JJ
cord-023439-r04y1j22	74	8	signs	sign	NNS
cord-023439-r04y1j22	74	9	of	of	IN
cord-023439-r04y1j22	74	10	arthritis	arthritis	NN
cord-023439-r04y1j22	74	11	were	be	VBD
cord-023439-r04y1j22	74	12	negative	negative	JJ
cord-023439-r04y1j22	74	13	.	.	.
cord-023439-r04y1j22	75	1	By	by	IN
cord-023439-r04y1j22	75	2	morphology	morphology	NN
cord-023439-r04y1j22	75	3	,	,	,
cord-023439-r04y1j22	75	4	we	-PRON-	PRP
cord-023439-r04y1j22	75	5	state	state	VBP
cord-023439-r04y1j22	75	6	that	that	IN
cord-023439-r04y1j22	75	7	some	some	DT
cord-023439-r04y1j22	75	8	infiltrating	infiltrate	VBG
cord-023439-r04y1j22	75	9	macrophages	macrophage	NNS
cord-023439-r04y1j22	75	10	as	as	RB
cord-023439-r04y1j22	75	11	well	well	RB
cord-023439-r04y1j22	75	12	as	as	IN
cord-023439-r04y1j22	75	13	the	the	DT
cord-023439-r04y1j22	75	14	cartilage	cartilage	NN
cord-023439-r04y1j22	75	15	surface	surface	NN
cord-023439-r04y1j22	75	16	stain	stain	NN
cord-023439-r04y1j22	75	17	positive	positive	JJ
cord-023439-r04y1j22	75	18	for	for	IN
cord-023439-r04y1j22	75	19	citrulline	citrulline	NN
cord-023439-r04y1j22	75	20	,	,	,
cord-023439-r04y1j22	75	21	while	while	IN
cord-023439-r04y1j22	75	22	the	the	DT
cord-023439-r04y1j22	75	23	major	major	JJ
cord-023439-r04y1j22	75	24	source	source	NN
cord-023439-r04y1j22	75	25	of	of	IN
cord-023439-r04y1j22	75	26	citrullinated	citrullinate	VBN
cord-023439-r04y1j22	75	27	proteins	protein	NNS
cord-023439-r04y1j22	75	28	appears	appear	VBZ
cord-023439-r04y1j22	75	29	to	to	TO
cord-023439-r04y1j22	75	30	be	be	VB
cord-023439-r04y1j22	75	31	fibrin	fibrin	NN
cord-023439-r04y1j22	75	32	depositions	deposition	NNS
cord-023439-r04y1j22	75	33	.	.	.
cord-023439-r04y1j22	76	1	A	a	DT
cord-023439-r04y1j22	76	2	specific	specific	JJ
cord-023439-r04y1j22	76	3	Cit	Cit	NNP
cord-023439-r04y1j22	76	4	-	-	HYPH
cord-023439-r04y1j22	76	5	RSA	RSA	NNP
cord-023439-r04y1j22	76	6	T	t	NN
cord-023439-r04y1j22	76	7	-	-	HYPH
cord-023439-r04y1j22	76	8	cell	cell	NN
cord-023439-r04y1j22	76	9	response	response	NN
cord-023439-r04y1j22	76	10	was	be	VBD
cord-023439-r04y1j22	76	11	observed	observe	VBN
cord-023439-r04y1j22	76	12	in	in	IN
cord-023439-r04y1j22	76	13	animals	animal	NNS
cord-023439-r04y1j22	76	14	challenged	challenge	VBN
cord-023439-r04y1j22	76	15	by	by	IN
cord-023439-r04y1j22	76	16	citrullinated	citrullinate	VBN
cord-023439-r04y1j22	76	17	RSA	RSA	NNP
cord-023439-r04y1j22	76	18	,	,	,
cord-023439-r04y1j22	76	19	no	no	DT
cord-023439-r04y1j22	76	20	response	response	NN
cord-023439-r04y1j22	76	21	was	be	VBD
cord-023439-r04y1j22	76	22	recorded	record	VBN
cord-023439-r04y1j22	76	23	when	when	WRB
cord-023439-r04y1j22	76	24	RSA	RSA	NNP
cord-023439-r04y1j22	76	25	was	be	VBD
cord-023439-r04y1j22	76	26	used	use	VBN
cord-023439-r04y1j22	76	27	as	as	IN
cord-023439-r04y1j22	76	28	a	a	DT
cord-023439-r04y1j22	76	29	stimulus	stimulus	NN
cord-023439-r04y1j22	76	30	.	.	.
cord-023439-r04y1j22	77	1	The	the	DT
cord-023439-r04y1j22	77	2	IgG	igg	NN
cord-023439-r04y1j22	77	3	analysis	analysis	NN
cord-023439-r04y1j22	77	4	reveals	reveal	VBZ
cord-023439-r04y1j22	77	5	not	not	RB
cord-023439-r04y1j22	77	6	only	only	RB
cord-023439-r04y1j22	77	7	a	a	DT
cord-023439-r04y1j22	77	8	response	response	NN
cord-023439-r04y1j22	77	9	towards	towards	IN
cord-023439-r04y1j22	77	10	the	the	DT
cord-023439-r04y1j22	77	11	modified	modify	VBN
cord-023439-r04y1j22	77	12	protein	protein	NN
cord-023439-r04y1j22	77	13	but	but	CC
cord-023439-r04y1j22	77	14	also	also	RB
cord-023439-r04y1j22	77	15	cross	cross	NN
cord-023439-r04y1j22	77	16	-	-	NN
cord-023439-r04y1j22	77	17	reactivity	reactivity	NN
cord-023439-r04y1j22	77	18	to	to	IN
cord-023439-r04y1j22	77	19	native	native	JJ
cord-023439-r04y1j22	77	20	RSA	RSA	NNP
cord-023439-r04y1j22	77	21	.	.	.
cord-023439-r04y1j22	78	1	No	no	DT
cord-023439-r04y1j22	78	2	T	t	NN
cord-023439-r04y1j22	78	3	-	-	HYPH
cord-023439-r04y1j22	78	4	cell	cell	NN
cord-023439-r04y1j22	78	5	or	or	CC
cord-023439-r04y1j22	78	6	B	b	NN
cord-023439-r04y1j22	78	7	-	-	HYPH
cord-023439-r04y1j22	78	8	cell	cell	NN
cord-023439-r04y1j22	78	9	response	response	NN
cord-023439-r04y1j22	78	10	was	be	VBD
cord-023439-r04y1j22	78	11	noted	note	VBN
cord-023439-r04y1j22	78	12	in	in	IN
cord-023439-r04y1j22	78	13	animals	animal	NNS
cord-023439-r04y1j22	78	14	injected	inject	VBN
cord-023439-r04y1j22	78	15	with	with	IN
cord-023439-r04y1j22	78	16	unmodified	unmodified	JJ
cord-023439-r04y1j22	78	17	RSA	rsa	NN
cord-023439-r04y1j22	78	18	.	.	.
cord-023439-r04y1j22	79	1	Cit	Cit	NNP
cord-023439-r04y1j22	79	2	-	-	HYPH
cord-023439-r04y1j22	79	3	CII	CII	NNP
cord-023439-r04y1j22	79	4	induced	induce	VBD
cord-023439-r04y1j22	79	5	a	a	DT
cord-023439-r04y1j22	79	6	disease	disease	NN
cord-023439-r04y1j22	79	7	with	with	IN
cord-023439-r04y1j22	79	8	higher	high	JJR
cord-023439-r04y1j22	79	9	incidence	incidence	NN
cord-023439-r04y1j22	79	10	and	and	CC
cord-023439-r04y1j22	79	11	earlier	early	JJR
cord-023439-r04y1j22	79	12	onset	onset	NN
cord-023439-r04y1j22	79	13	than	than	IN
cord-023439-r04y1j22	79	14	did	do	VBD
cord-023439-r04y1j22	79	15	the	the	DT
cord-023439-r04y1j22	79	16	native	native	JJ
cord-023439-r04y1j22	79	17	counterpart	counterpart	NN
cord-023439-r04y1j22	79	18	.	.	.
cord-023439-r04y1j22	80	1	We	-PRON-	PRP
cord-023439-r04y1j22	80	2	conclude	conclude	VBP
cord-023439-r04y1j22	80	3	that	that	IN
cord-023439-r04y1j22	80	4	,	,	,
cord-023439-r04y1j22	80	5	in	in	IN
cord-023439-r04y1j22	80	6	contrast	contrast	NN
cord-023439-r04y1j22	80	7	to	to	IN
cord-023439-r04y1j22	80	8	the	the	DT
cord-023439-r04y1j22	80	9	human	human	JJ
cord-023439-r04y1j22	80	10	disease	disease	NN
cord-023439-r04y1j22	80	11	,	,	,
cord-023439-r04y1j22	80	12	citrulline	citrulline	NN
cord-023439-r04y1j22	80	13	does	do	VBZ
cord-023439-r04y1j22	80	14	not	not	RB
cord-023439-r04y1j22	80	15	seem	seem	VB
cord-023439-r04y1j22	80	16	to	to	TO
cord-023439-r04y1j22	80	17	appear	appear	VB
cord-023439-r04y1j22	80	18	before	before	IN
cord-023439-r04y1j22	80	19	clinical	clinical	JJ
cord-023439-r04y1j22	80	20	signs	sign	NNS
cord-023439-r04y1j22	80	21	.	.	.
cord-023439-r04y1j22	81	1	As	as	IN
cord-023439-r04y1j22	81	2	inflammation	inflammation	NN
cord-023439-r04y1j22	81	3	proceeds	proceed	NNS
cord-023439-r04y1j22	81	4	,	,	,
cord-023439-r04y1j22	81	5	citrulline	citrulline	NN
cord-023439-r04y1j22	81	6	is	be	VBZ
cord-023439-r04y1j22	81	7	detected	detect	VBN
cord-023439-r04y1j22	81	8	specifically	specifically	RB
cord-023439-r04y1j22	81	9	in	in	IN
cord-023439-r04y1j22	81	10	the	the	DT
cord-023439-r04y1j22	81	11	joints	joint	NNS
cord-023439-r04y1j22	81	12	.	.	.
cord-023439-r04y1j22	82	1	All	all	DT
cord-023439-r04y1j22	82	2	other	other	JJ
cord-023439-r04y1j22	82	3	organs	organ	NNS
cord-023439-r04y1j22	82	4	investigated	investigate	VBN
cord-023439-r04y1j22	82	5	were	be	VBD
cord-023439-r04y1j22	82	6	negative	negative	JJ
cord-023439-r04y1j22	82	7	.	.	.
cord-023439-r04y1j22	83	1	We	-PRON-	PRP
cord-023439-r04y1j22	83	2	also	also	RB
cord-023439-r04y1j22	83	3	conclude	conclude	VBP
cord-023439-r04y1j22	83	4	that	that	IN
cord-023439-r04y1j22	83	5	citrullination	citrullination	NN
cord-023439-r04y1j22	83	6	of	of	IN
cord-023439-r04y1j22	83	7	a	a	DT
cord-023439-r04y1j22	83	8	protein	protein	NN
cord-023439-r04y1j22	83	9	can	can	MD
cord-023439-r04y1j22	83	10	break	break	VB
cord-023439-r04y1j22	83	11	tolerance	tolerance	NN
cord-023439-r04y1j22	83	12	and	and	CC
cord-023439-r04y1j22	83	13	increase	increase	VB
cord-023439-r04y1j22	83	14	its	-PRON-	PRP$
cord-023439-r04y1j22	83	15	arthritogenic	arthritogenic	JJ
cord-023439-r04y1j22	83	16	properties	property	NNS
cord-023439-r04y1j22	83	17	.	.	.
cord-023439-r04y1j22	84	1	Ectopic	ectopic	JJ
cord-023439-r04y1j22	84	2	germinal	germinal	JJ
cord-023439-r04y1j22	84	3	centers	center	NNS
cord-023439-r04y1j22	84	4	(	(	-LRB-
cord-023439-r04y1j22	84	5	GCs	GCs	NNP
cord-023439-r04y1j22	84	6	)	)	-RRB-
cord-023439-r04y1j22	84	7	can	can	MD
cord-023439-r04y1j22	84	8	be	be	VB
cord-023439-r04y1j22	84	9	detected	detect	VBN
cord-023439-r04y1j22	84	10	in	in	IN
cord-023439-r04y1j22	84	11	the	the	DT
cord-023439-r04y1j22	84	12	salivary	salivary	JJ
cord-023439-r04y1j22	84	13	glands	gland	NNS
cord-023439-r04y1j22	84	14	of	of	IN
cord-023439-r04y1j22	84	15	approximately	approximately	RB
cord-023439-r04y1j22	84	16	1/5	1/5	CD
cord-023439-r04y1j22	84	17	of	of	IN
cord-023439-r04y1j22	84	18	patients	patient	NNS
cord-023439-r04y1j22	84	19	with	with	IN
cord-023439-r04y1j22	84	20	Sjögren	Sjögren	NNP
cord-023439-r04y1j22	84	21	's	's	POS
cord-023439-r04y1j22	84	22	syndrome	syndrome	NN
cord-023439-r04y1j22	84	23	(	(	-LRB-
cord-023439-r04y1j22	84	24	SS	SS	NNP
cord-023439-r04y1j22	84	25	)	)	-RRB-
cord-023439-r04y1j22	84	26	and	and	CC
cord-023439-r04y1j22	84	27	appear	appear	VB
cord-023439-r04y1j22	84	28	in	in	IN
cord-023439-r04y1j22	84	29	both	both	DT
cord-023439-r04y1j22	84	30	primary	primary	JJ
cord-023439-r04y1j22	84	31	and	and	CC
cord-023439-r04y1j22	84	32	secondary	secondary	JJ
cord-023439-r04y1j22	84	33	SS	ss	NN
cord-023439-r04y1j22	84	34	.	.	.
cord-023439-r04y1j22	85	1	Previously	previously	RB
cord-023439-r04y1j22	85	2	,	,	,
cord-023439-r04y1j22	85	3	ectopic	ectopic	JJ
cord-023439-r04y1j22	85	4	GC	GC	NNP
cord-023439-r04y1j22	85	5	have	have	VBP
cord-023439-r04y1j22	85	6	been	be	VBN
cord-023439-r04y1j22	85	7	associated	associate	VBN
cord-023439-r04y1j22	85	8	with	with	IN
cord-023439-r04y1j22	85	9	increased	increase	VBN
cord-023439-r04y1j22	85	10	local	local	JJ
cord-023439-r04y1j22	85	11	autoantibody	autoantibody	NN
cord-023439-r04y1j22	85	12	production	production	NN
cord-023439-r04y1j22	85	13	.	.	.
cord-023439-r04y1j22	86	1	The	the	DT
cord-023439-r04y1j22	86	2	aim	aim	NN
cord-023439-r04y1j22	86	3	of	of	IN
cord-023439-r04y1j22	86	4	this	this	DT
cord-023439-r04y1j22	86	5	study	study	NN
cord-023439-r04y1j22	86	6	was	be	VBD
cord-023439-r04y1j22	86	7	to	to	TO
cord-023439-r04y1j22	86	8	determine	determine	VB
cord-023439-r04y1j22	86	9	whether	whether	IN
cord-023439-r04y1j22	86	10	GC	GC	NNP
cord-023439-r04y1j22	86	11	in	in	IN
cord-023439-r04y1j22	86	12	primary	primary	JJ
cord-023439-r04y1j22	86	13	Sjögren	Sjögren	NNP
cord-023439-r04y1j22	86	14	's	's	POS
cord-023439-r04y1j22	86	15	syndrome	syndrome	NN
cord-023439-r04y1j22	86	16	(	(	-LRB-
cord-023439-r04y1j22	86	17	pSS	pSS	NNP
cord-023439-r04y1j22	86	18	)	)	-RRB-
cord-023439-r04y1j22	86	19	defines	define	VBZ
cord-023439-r04y1j22	86	20	a	a	DT
cord-023439-r04y1j22	86	21	distinct	distinct	JJ
cord-023439-r04y1j22	86	22	seroimmunological	seroimmunological	JJ
cord-023439-r04y1j22	86	23	phenotype	phenotype	NN
cord-023439-r04y1j22	86	24	.	.	.
cord-023439-r04y1j22	87	1	Retrospectively	retrospectively	RB
cord-023439-r04y1j22	87	2	,	,	,
cord-023439-r04y1j22	87	3	a	a	DT
cord-023439-r04y1j22	87	4	material	material	NN
cord-023439-r04y1j22	87	5	of	of	IN
cord-023439-r04y1j22	87	6	130	130	CD
cord-023439-r04y1j22	87	7	haematoxylin	haematoxylin	NN
cord-023439-r04y1j22	87	8	and	and	CC
cord-023439-r04y1j22	87	9	eosin	eosin	NN
cord-023439-r04y1j22	87	10	-	-	HYPH
cord-023439-r04y1j22	87	11	stained	stain	VBN
cord-023439-r04y1j22	87	12	paraffin	paraffin	NN
cord-023439-r04y1j22	87	13	-	-	HYPH
cord-023439-r04y1j22	87	14	embedded	embed	VBN
cord-023439-r04y1j22	87	15	tissue	tissue	NN
cord-023439-r04y1j22	87	16	sections	section	NNS
cord-023439-r04y1j22	87	17	of	of	IN
cord-023439-r04y1j22	87	18	minor	minor	JJ
cord-023439-r04y1j22	87	19	salivary	salivary	NN
cord-023439-r04y1j22	87	20	gland	gland	NN
cord-023439-r04y1j22	87	21	tissue	tissue	NN
cord-023439-r04y1j22	87	22	from	from	IN
cord-023439-r04y1j22	87	23	patients	patient	NNS
cord-023439-r04y1j22	87	24	with	with	IN
cord-023439-r04y1j22	87	25	pSS	pSS	NNP
cord-023439-r04y1j22	87	26	was	be	VBD
cord-023439-r04y1j22	87	27	morphologically	morphologically	RB
cord-023439-r04y1j22	87	28	screened	screen	VBN
cord-023439-r04y1j22	87	29	for	for	IN
cord-023439-r04y1j22	87	30	the	the	DT
cord-023439-r04y1j22	87	31	presence	presence	NN
cord-023439-r04y1j22	87	32	of	of	IN
cord-023439-r04y1j22	87	33	ectopic	ectopic	JJ
cord-023439-r04y1j22	87	34	GC	GC	NNP
cord-023439-r04y1j22	87	35	.	.	.
cord-023439-r04y1j22	88	1	GC	GC	NNP
cord-023439-r04y1j22	88	2	-	-	HYPH
cord-023439-r04y1j22	88	3	like	like	JJ
cord-023439-r04y1j22	88	4	lesions	lesion	NNS
cord-023439-r04y1j22	88	5	were	be	VBD
cord-023439-r04y1j22	88	6	detected	detect	VBN
cord-023439-r04y1j22	88	7	in	in	IN
cord-023439-r04y1j22	88	8	33/130	33/130	CD
cord-023439-r04y1j22	88	9	(	(	-LRB-
cord-023439-r04y1j22	88	10	25	25	CD
cord-023439-r04y1j22	88	11	%	%	NN
cord-023439-r04y1j22	88	12	)	)	-RRB-
cord-023439-r04y1j22	88	13	of	of	IN
cord-023439-r04y1j22	88	14	the	the	DT
cord-023439-r04y1j22	88	15	pSS	pSS	NNP
cord-023439-r04y1j22	88	16	patients	patient	NNS
cord-023439-r04y1j22	88	17	.	.	.
cord-023439-r04y1j22	89	1	Seventy	seventy	CD
cord-023439-r04y1j22	89	2	-	-	HYPH
cord-023439-r04y1j22	89	3	two	two	CD
cord-023439-r04y1j22	89	4	pSS	ps	NNS
cord-023439-r04y1j22	89	5	patients	patient	NNS
cord-023439-r04y1j22	89	6	lacking	lack	VBG
cord-023439-r04y1j22	89	7	these	these	DT
cord-023439-r04y1j22	89	8	structures	structure	NNS
cord-023439-r04y1j22	89	9	(	(	-LRB-
cord-023439-r04y1j22	89	10	GC-	GC-	NNP
cord-023439-r04y1j22	89	11	)	)	-RRB-
cord-023439-r04y1j22	89	12	were	be	VBD
cord-023439-r04y1j22	89	13	randomly	randomly	RB
cord-023439-r04y1j22	89	14	selected	select	VBN
cord-023439-r04y1j22	89	15	for	for	IN
cord-023439-r04y1j22	89	16	comparison	comparison	NN
cord-023439-r04y1j22	89	17	.	.	.
cord-023439-r04y1j22	90	1	Focus	focus	JJ
cord-023439-r04y1j22	90	2	score	score	NN
cord-023439-r04y1j22	90	3	was	be	VBD
cord-023439-r04y1j22	90	4	significantly	significantly	RB
cord-023439-r04y1j22	90	5	increased	increase	VBN
cord-023439-r04y1j22	90	6	in	in	IN
cord-023439-r04y1j22	90	7	the	the	DT
cord-023439-r04y1j22	90	8	GC	GC	NNP
cord-023439-r04y1j22	90	9	þ	þ	CD
cord-023439-r04y1j22	90	10	patients	patient	NNS
cord-023439-r04y1j22	90	11	compared	compare	VBN
cord-023439-r04y1j22	90	12	to	to	IN
cord-023439-r04y1j22	90	13	the	the	DT
cord-023439-r04y1j22	90	14	GCpatients	GCpatients	NNP
cord-023439-r04y1j22	91	1	(	(	-LRB-
cord-023439-r04y1j22	91	2	P	p	NN
cord-023439-r04y1j22	91	3	¼	¼	CD
cord-023439-r04y1j22	91	4	0.035	0.035	CD
cord-023439-r04y1j22	91	5	)	)	-RRB-
cord-023439-r04y1j22	91	6	.	.	.
cord-023439-r04y1j22	92	1	In	in	IN
cord-023439-r04y1j22	92	2	the	the	DT
cord-023439-r04y1j22	92	3	GC	GC	NNP
cord-023439-r04y1j22	92	4	þ	þ	NNP
cord-023439-r04y1j22	92	5	group	group	NN
cord-023439-r04y1j22	92	6	,	,	,
cord-023439-r04y1j22	92	7	54.5	54.5	CD
cord-023439-r04y1j22	92	8	%	%	NN
cord-023439-r04y1j22	92	9	of	of	IN
cord-023439-r04y1j22	92	10	the	the	DT
cord-023439-r04y1j22	92	11	patients	patient	NNS
cord-023439-r04y1j22	92	12	presented	present	VBN
cord-023439-r04y1j22	92	13	with	with	IN
cord-023439-r04y1j22	92	14	anti	anti	JJ
cord-023439-r04y1j22	92	15	-	-	JJ
cord-023439-r04y1j22	92	16	Ro	ro	JJ
cord-023439-r04y1j22	92	17	/	/	SYM
cord-023439-r04y1j22	92	18	SSA	SSA	NNP
cord-023439-r04y1j22	92	19	compared	compare	VBN
cord-023439-r04y1j22	92	20	to	to	IN
cord-023439-r04y1j22	92	21	43.7	43.7	CD
cord-023439-r04y1j22	92	22	%	%	NN
cord-023439-r04y1j22	92	23	in	in	IN
cord-023439-r04y1j22	92	24	the	the	DT
cord-023439-r04y1j22	92	25	GCgroup	GCgroup	NNP
cord-023439-r04y1j22	92	26	.	.	.
cord-023439-r04y1j22	93	1	Anti	Anti	NNP
cord-023439-r04y1j22	93	2	-	-	NNP
cord-023439-r04y1j22	93	3	La	La	NNP
cord-023439-r04y1j22	93	4	/	/	SYM
cord-023439-r04y1j22	93	5	SSB	SSB	NNP
cord-023439-r04y1j22	93	6	was	be	VBD
cord-023439-r04y1j22	93	7	detected	detect	VBN
cord-023439-r04y1j22	93	8	in	in	IN
cord-023439-r04y1j22	93	9	31.3	31.3	CD
cord-023439-r04y1j22	93	10	%	%	NN
cord-023439-r04y1j22	93	11	of	of	IN
cord-023439-r04y1j22	93	12	the	the	DT
cord-023439-r04y1j22	93	13	GC	GC	NNP
cord-023439-r04y1j22	93	14	þ	þ	CD
cord-023439-r04y1j22	93	15	patients	patient	NNS
cord-023439-r04y1j22	93	16	compared	compare	VBN
cord-023439-r04y1j22	93	17	to	to	IN
cord-023439-r04y1j22	93	18	25.7	25.7	CD
cord-023439-r04y1j22	93	19	%	%	NN
cord-023439-r04y1j22	93	20	of	of	IN
cord-023439-r04y1j22	93	21	the	the	DT
cord-023439-r04y1j22	93	22	GCpatients	GCpatients	NNP
cord-023439-r04y1j22	93	23	.	.	.
cord-023439-r04y1j22	94	1	Sixty	sixty	CD
cord-023439-r04y1j22	94	2	-	-	HYPH
cord-023439-r04y1j22	94	3	one	one	CD
cord-023439-r04y1j22	94	4	percentage	percentage	NN
cord-023439-r04y1j22	94	5	of	of	IN
cord-023439-r04y1j22	94	6	GC	GC	NNP
cord-023439-r04y1j22	94	7	þ	þ	NNP
cord-023439-r04y1j22	94	8	patients	patient	NNS
cord-023439-r04y1j22	94	9	presented	present	VBN
cord-023439-r04y1j22	94	10	with	with	IN
cord-023439-r04y1j22	94	11	increased	increase	VBN
cord-023439-r04y1j22	94	12	levels	level	NNS
cord-023439-r04y1j22	94	13	of	of	IN
cord-023439-r04y1j22	94	14	IgG	IgG	NNP
cord-023439-r04y1j22	94	15	,	,	,
cord-023439-r04y1j22	94	16	a	a	DT
cord-023439-r04y1j22	94	17	nonsignificant	nonsignificant	JJ
cord-023439-r04y1j22	94	18	difference	difference	NN
cord-023439-r04y1j22	94	19	when	when	WRB
cord-023439-r04y1j22	94	20	compared	compare	VBN
cord-023439-r04y1j22	94	21	to	to	IN
cord-023439-r04y1j22	94	22	39.4	39.4	CD
cord-023439-r04y1j22	94	23	%	%	NN
cord-023439-r04y1j22	94	24	in	in	IN
cord-023439-r04y1j22	94	25	the	the	DT
cord-023439-r04y1j22	94	26	GCpatients	GCpatients	NNP
cord-023439-r04y1j22	95	1	(	(	-LRB-
cord-023439-r04y1j22	95	2	P	p	NN
cord-023439-r04y1j22	95	3	¼	¼	NNP
cord-023439-r04y1j22	95	4	0.089	0.089	CD
cord-023439-r04y1j22	95	5	)	)	-RRB-
cord-023439-r04y1j22	95	6	.	.	.
cord-023439-r04y1j22	96	1	Levels	level	NNS
cord-023439-r04y1j22	96	2	of	of	IN
cord-023439-r04y1j22	96	3	RF	RF	NNP
cord-023439-r04y1j22	96	4	,	,	,
cord-023439-r04y1j22	96	5	ANA	ANA	NNP
cord-023439-r04y1j22	96	6	,	,	,
cord-023439-r04y1j22	96	7	ENA	ENA	NNP
cord-023439-r04y1j22	96	8	,	,	,
cord-023439-r04y1j22	96	9	IgM	IgM	NNP
cord-023439-r04y1j22	96	10	and	and	CC
cord-023439-r04y1j22	96	11	IgA	IgA	NNP
cord-023439-r04y1j22	96	12	were	be	VBD
cord-023439-r04y1j22	96	13	similar	similar	JJ
cord-023439-r04y1j22	96	14	in	in	IN
cord-023439-r04y1j22	96	15	both	both	DT
cord-023439-r04y1j22	96	16	patient	patient	JJ
cord-023439-r04y1j22	96	17	groups	group	NNS
cord-023439-r04y1j22	96	18	,	,	,
cord-023439-r04y1j22	96	19	as	as	IN
cord-023439-r04y1j22	96	20	were	be	VBD
cord-023439-r04y1j22	96	21	ESR	ESR	NNP
cord-023439-r04y1j22	96	22	and	and	CC
cord-023439-r04y1j22	96	23	CRP	CRP	NNP
cord-023439-r04y1j22	96	24	.	.	.
cord-023439-r04y1j22	97	1	In	in	IN
cord-023439-r04y1j22	97	2	conclusion	conclusion	NN
cord-023439-r04y1j22	97	3	,	,	,
cord-023439-r04y1j22	97	4	patients	patient	NNS
cord-023439-r04y1j22	97	5	with	with	IN
cord-023439-r04y1j22	97	6	ectopic	ectopic	JJ
cord-023439-r04y1j22	97	7	GC	GC	NNP
cord-023439-r04y1j22	97	8	have	have	VBP
cord-023439-r04y1j22	97	9	a	a	DT
cord-023439-r04y1j22	97	10	higher	high	JJR
cord-023439-r04y1j22	97	11	focus	focus	NN
cord-023439-r04y1j22	97	12	score	score	NN
cord-023439-r04y1j22	97	13	and	and	CC
cord-023439-r04y1j22	97	14	more	more	RBR
cord-023439-r04y1j22	97	15	often	often	RB
cord-023439-r04y1j22	97	16	present	present	JJ
cord-023439-r04y1j22	97	17	with	with	IN
cord-023439-r04y1j22	97	18	autoantibodies	autoantibody	NNS
cord-023439-r04y1j22	97	19	and	and	CC
cord-023439-r04y1j22	97	20	increased	increase	VBN
cord-023439-r04y1j22	97	21	levels	level	NNS
cord-023439-r04y1j22	97	22	of	of	IN
cord-023439-r04y1j22	97	23	IgG	igg	NN
cord-023439-r04y1j22	97	24	compared	compare	VBN
cord-023439-r04y1j22	97	25	to	to	IN
cord-023439-r04y1j22	97	26	pSS	pSS	NNP
cord-023439-r04y1j22	97	27	patients	patient	NNS
cord-023439-r04y1j22	97	28	with	with	IN
cord-023439-r04y1j22	97	29	regular	regular	JJ
cord-023439-r04y1j22	97	30	focal	focal	JJ
cord-023439-r04y1j22	97	31	infiltration	infiltration	NN
cord-023439-r04y1j22	97	32	(	(	-LRB-
cord-023439-r04y1j22	97	33	GC	GC	NNP
cord-023439-r04y1j22	97	34	-	-	,
cord-023439-r04y1j22	97	35	)	)	-RRB-
cord-023439-r04y1j22	97	36	.	.	.
cord-023439-r04y1j22	98	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	98	2	findings	finding	NNS
cord-023439-r04y1j22	98	3	may	may	MD
cord-023439-r04y1j22	98	4	indicate	indicate	VB
cord-023439-r04y1j22	98	5	a	a	DT
cord-023439-r04y1j22	98	6	certain	certain	JJ
cord-023439-r04y1j22	98	7	seroimmunological	seroimmunological	JJ
cord-023439-r04y1j22	98	8	phenotype	phenotype	NN
cord-023439-r04y1j22	98	9	and	and	CC
cord-023439-r04y1j22	98	10	warrant	warrant	VB
cord-023439-r04y1j22	98	11	for	for	IN
cord-023439-r04y1j22	98	12	further	further	JJ
cord-023439-r04y1j22	98	13	prospective	prospective	JJ
cord-023439-r04y1j22	98	14	studies	study	NNS
cord-023439-r04y1j22	98	15	.	.	.
cord-023439-r04y1j22	99	1	Association	association	NN
cord-023439-r04y1j22	99	2	between	between	IN
cord-023439-r04y1j22	99	3	Mannose	Mannose	NNP
cord-023439-r04y1j22	99	4	-	-	HYPH
cord-023439-r04y1j22	99	5	Binding	bind	VBG
cord-023439-r04y1j22	99	6	Lectin	Lectin	NNP
cord-023439-r04y1j22	99	7	and	and	CC
cord-023439-r04y1j22	99	8	Vascular	Vascular	NNP
cord-023439-r04y1j22	99	9	Complications	Complications	NNPS
cord-023439-r04y1j22	99	10	in	in	IN
cord-023439-r04y1j22	99	11	Type	type	NN
cord-023439-r04y1j22	99	12	1	1	CD
cord-023439-r04y1j22	99	13	Diabetes	diabetes	NN
cord-023439-r04y1j22	99	14	Complement	Complement	NNP
cord-023439-r04y1j22	99	15	activation	activation	NN
cord-023439-r04y1j22	99	16	and	and	CC
cord-023439-r04y1j22	99	17	inflammation	inflammation	NN
cord-023439-r04y1j22	99	18	have	have	VBP
cord-023439-r04y1j22	99	19	been	be	VBN
cord-023439-r04y1j22	99	20	suggested	suggest	VBN
cord-023439-r04y1j22	99	21	in	in	IN
cord-023439-r04y1j22	99	22	the	the	DT
cord-023439-r04y1j22	99	23	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	99	24	of	of	IN
cord-023439-r04y1j22	99	25	diabetic	diabetic	JJ
cord-023439-r04y1j22	99	26	vascular	vascular	JJ
cord-023439-r04y1j22	99	27	lesions	lesion	NNS
cord-023439-r04y1j22	99	28	.	.	.
cord-023439-r04y1j22	100	1	We	-PRON-	PRP
cord-023439-r04y1j22	100	2	investigated	investigate	VBD
cord-023439-r04y1j22	100	3	serum	serum	NN
cord-023439-r04y1j22	100	4	mannose	mannose	NN
cord-023439-r04y1j22	100	5	-	-	HYPH
cord-023439-r04y1j22	100	6	binding	bind	VBG
cord-023439-r04y1j22	100	7	lectin	lectin	NN
cord-023439-r04y1j22	100	8	(	(	-LRB-
cord-023439-r04y1j22	100	9	MBL	MBL	NNP
cord-023439-r04y1j22	100	10	)	)	-RRB-
cord-023439-r04y1j22	100	11	levels	level	NNS
cord-023439-r04y1j22	100	12	and	and	CC
cord-023439-r04y1j22	100	13	polymorphisms	polymorphism	NNS
cord-023439-r04y1j22	100	14	in	in	IN
cord-023439-r04y1j22	100	15	the	the	DT
cord-023439-r04y1j22	100	16	MBL	MBL	NNP
cord-023439-r04y1j22	100	17	gene	gene	NN
cord-023439-r04y1j22	100	18	in	in	IN
cord-023439-r04y1j22	100	19	type	type	NN
cord-023439-r04y1j22	100	20	1	1	CD
cord-023439-r04y1j22	100	21	diabetic	diabetic	JJ
cord-023439-r04y1j22	100	22	(	(	-LRB-
cord-023439-r04y1j22	100	23	T1DM	T1DM	NNP
cord-023439-r04y1j22	100	24	)	)	-RRB-
cord-023439-r04y1j22	100	25	patients	patient	NNS
cord-023439-r04y1j22	100	26	with	with	IN
cord-023439-r04y1j22	100	27	and	and	CC
cord-023439-r04y1j22	100	28	without	without	IN
cord-023439-r04y1j22	100	29	diabetic	diabetic	JJ
cord-023439-r04y1j22	100	30	nephropathy	nephropathy	NN
cord-023439-r04y1j22	100	31	and	and	CC
cord-023439-r04y1j22	100	32	associated	associate	VBD
cord-023439-r04y1j22	100	33	macrovascular	macrovascular	JJ
cord-023439-r04y1j22	100	34	complications	complication	NNS
cord-023439-r04y1j22	100	35	.	.	.
cord-023439-r04y1j22	101	1	Polymorphisms	polymorphism	NNS
cord-023439-r04y1j22	101	2	in	in	IN
cord-023439-r04y1j22	101	3	the	the	DT
cord-023439-r04y1j22	101	4	MBL	MBL	NNP
cord-023439-r04y1j22	101	5	gene	gene	NN
cord-023439-r04y1j22	101	6	and	and	CC
cord-023439-r04y1j22	101	7	serum	serum	NN
cord-023439-r04y1j22	101	8	MBL	MBL	NNP
cord-023439-r04y1j22	101	9	levels	level	NNS
cord-023439-r04y1j22	101	10	were	be	VBD
cord-023439-r04y1j22	101	11	determined	determine	VBN
cord-023439-r04y1j22	101	12	in	in	IN
cord-023439-r04y1j22	101	13	199	199	CD
cord-023439-r04y1j22	101	14	T1DM	T1DM	NNP
cord-023439-r04y1j22	101	15	patients	patient	NNS
cord-023439-r04y1j22	101	16	with	with	IN
cord-023439-r04y1j22	101	17	overt	overt	JJ
cord-023439-r04y1j22	101	18	nephropathy	nephropathy	NN
cord-023439-r04y1j22	101	19	and	and	CC
cord-023439-r04y1j22	101	20	192	192	CD
cord-023439-r04y1j22	101	21	T1DM	T1DM	NNP
cord-023439-r04y1j22	101	22	patients	patient	NNS
cord-023439-r04y1j22	101	23	with	with	IN
cord-023439-r04y1j22	101	24	persistent	persistent	JJ
cord-023439-r04y1j22	101	25	normoalbuminuria	normoalbuminuria	NNP
cord-023439-r04y1j22	101	26	matched	match	VBN
cord-023439-r04y1j22	101	27	for	for	IN
cord-023439-r04y1j22	101	28	age	age	NN
cord-023439-r04y1j22	101	29	,	,	,
cord-023439-r04y1j22	101	30	sex	sex	NN
cord-023439-r04y1j22	101	31	and	and	CC
cord-023439-r04y1j22	101	32	duration	duration	NN
cord-023439-r04y1j22	101	33	of	of	IN
cord-023439-r04y1j22	101	34	diabetes	diabete	NNS
cord-023439-r04y1j22	101	35	as	as	RB
cord-023439-r04y1j22	101	36	well	well	RB
cord-023439-r04y1j22	101	37	as	as	IN
cord-023439-r04y1j22	101	38	in	in	IN
cord-023439-r04y1j22	101	39	100	100	CD
cord-023439-r04y1j22	101	40	healthy	healthy	JJ
cord-023439-r04y1j22	101	41	control	control	NN
cord-023439-r04y1j22	101	42	subjects	subject	NNS
cord-023439-r04y1j22	101	43	.	.	.
cord-023439-r04y1j22	102	1	The	the	DT
cord-023439-r04y1j22	102	2	frequencies	frequency	NNS
cord-023439-r04y1j22	102	3	of	of	IN
cord-023439-r04y1j22	102	4	high	high	JJ
cord-023439-r04y1j22	102	5	and	and	CC
cord-023439-r04y1j22	102	6	low	low	JJ
cord-023439-r04y1j22	102	7	expression	expression	NN
cord-023439-r04y1j22	102	8	MBL	MBL	NNP
cord-023439-r04y1j22	102	9	genotypes	genotype	NNS
cord-023439-r04y1j22	102	10	were	be	VBD
cord-023439-r04y1j22	102	11	similar	similar	JJ
cord-023439-r04y1j22	102	12	in	in	IN
cord-023439-r04y1j22	102	13	patients	patient	NNS
cord-023439-r04y1j22	102	14	with	with	IN
cord-023439-r04y1j22	102	15	T1DM	t1dm	JJ
cord-023439-r04y1j22	102	16	and	and	CC
cord-023439-r04y1j22	102	17	healthy	healthy	JJ
cord-023439-r04y1j22	102	18	controls	control	NNS
cord-023439-r04y1j22	102	19	.	.	.
cord-023439-r04y1j22	103	1	High	high	JJ
cord-023439-r04y1j22	103	2	MBL	MBL	NNP
cord-023439-r04y1j22	103	3	genotypes	genotype	NNS
cord-023439-r04y1j22	103	4	were	be	VBD
cord-023439-r04y1j22	103	5	significantly	significantly	RB
cord-023439-r04y1j22	103	6	more	more	RBR
cord-023439-r04y1j22	103	7	frequent	frequent	JJ
cord-023439-r04y1j22	103	8	in	in	IN
cord-023439-r04y1j22	103	9	diabetic	diabetic	JJ
cord-023439-r04y1j22	103	10	patients	patient	NNS
cord-023439-r04y1j22	103	11	with	with	IN
cord-023439-r04y1j22	103	12	nephropathy	nephropathy	NN
cord-023439-r04y1j22	103	13	than	than	IN
cord-023439-r04y1j22	103	14	in	in	IN
cord-023439-r04y1j22	103	15	the	the	DT
cord-023439-r04y1j22	103	16	normoalbuminuric	normoalbuminuric	NNP
cord-023439-r04y1j22	103	17	group	group	NN
cord-023439-r04y1j22	103	18	,	,	,
cord-023439-r04y1j22	103	19	and	and	CC
cord-023439-r04y1j22	103	20	the	the	DT
cord-023439-r04y1j22	103	21	risk	risk	NN
cord-023439-r04y1j22	103	22	of	of	IN
cord-023439-r04y1j22	103	23	having	have	VBG
cord-023439-r04y1j22	103	24	nephropathy	nephropathy	NN
cord-023439-r04y1j22	103	25	,	,	,
cord-023439-r04y1j22	103	26	given	give	VBN
cord-023439-r04y1j22	103	27	a	a	DT
cord-023439-r04y1j22	103	28	high	high	JJ
cord-023439-r04y1j22	103	29	MBL	MBL	NNP
cord-023439-r04y1j22	103	30	genotype	genotype	NN
cord-023439-r04y1j22	103	31	,	,	,
cord-023439-r04y1j22	103	32	assessed	assess	VBN
cord-023439-r04y1j22	103	33	by	by	IN
cord-023439-r04y1j22	103	34	odds	odd	NNS
cord-023439-r04y1j22	103	35	ratio	ratio	NN
cord-023439-r04y1j22	103	36	was	be	VBD
cord-023439-r04y1j22	103	37	1.52	1.52	CD
cord-023439-r04y1j22	103	38	(	(	-LRB-
cord-023439-r04y1j22	103	39	1.02	1.02	CD
cord-023439-r04y1j22	103	40	-	-	SYM
cord-023439-r04y1j22	103	41	2.27	2.27	CD
cord-023439-r04y1j22	103	42	)	)	-RRB-
cord-023439-r04y1j22	103	43	,	,	,
cord-023439-r04y1j22	103	44	P	p	NN
cord-023439-r04y1j22	103	45	¼	¼	CD
cord-023439-r04y1j22	103	46	0.04	0.04	CD
cord-023439-r04y1j22	103	47	.	.	.
cord-023439-r04y1j22	104	1	Median	median	JJ
cord-023439-r04y1j22	104	2	serum	serum	NN
cord-023439-r04y1j22	104	3	MBL	MBL	NNP
cord-023439-r04y1j22	104	4	concentrations	concentration	NNS
cord-023439-r04y1j22	104	5	were	be	VBD
cord-023439-r04y1j22	104	6	significantly	significantly	RB
cord-023439-r04y1j22	104	7	higher	high	JJR
cord-023439-r04y1j22	104	8	in	in	IN
cord-023439-r04y1j22	104	9	patients	patient	NNS
cord-023439-r04y1j22	104	10	with	with	IN
cord-023439-r04y1j22	104	11	nephropathy	nephropathy	NN
cord-023439-r04y1j22	104	12	than	than	IN
cord-023439-r04y1j22	104	13	in	in	IN
cord-023439-r04y1j22	104	14	patients	patient	NNS
cord-023439-r04y1j22	104	15	with	with	IN
cord-023439-r04y1j22	104	16	normoalbuminuria	normoalbuminuria	NNP
cord-023439-r04y1j22	105	1	[	[	-LRB-
cord-023439-r04y1j22	105	2	2306	2306	CD
cord-023439-r04y1j22	105	3	mg	mg	NNP
cord-023439-r04y1j22	105	4	/	/	SYM
cord-023439-r04y1j22	105	5	l	l	NN
cord-023439-r04y1j22	105	6	(	(	-LRB-
cord-023439-r04y1j22	105	7	IQR	IQR	NNP
cord-023439-r04y1j22	105	8	753	753	CD
cord-023439-r04y1j22	105	9	-	-	HYPH
cord-023439-r04y1j22	105	10	4867	4867	CD
cord-023439-r04y1j22	105	11	mg	mg	NNP
cord-023439-r04y1j22	105	12	/	/	SYM
cord-023439-r04y1j22	105	13	l	l	NNP
cord-023439-r04y1j22	105	14	)	)	-RRB-
cord-023439-r04y1j22	105	15	versus	versus	IN
cord-023439-r04y1j22	105	16	1491	1491	CD
cord-023439-r04y1j22	105	17	mg	mg	NNP
cord-023439-r04y1j22	105	18	/	/	SYM
cord-023439-r04y1j22	105	19	l	l	NN
cord-023439-r04y1j22	105	20	(	(	-LRB-
cord-023439-r04y1j22	105	21	IQR	IQR	NNP
cord-023439-r04y1j22	105	22	577	577	CD
cord-023439-r04y1j22	105	23	-	-	HYPH
cord-023439-r04y1j22	105	24	2944	2944	CD
cord-023439-r04y1j22	105	25	)	)	-RRB-
cord-023439-r04y1j22	105	26	,	,	,
cord-023439-r04y1j22	105	27	P	p	NN
cord-023439-r04y1j22	105	28	¼	¼	CD
cord-023439-r04y1j22	105	29	0.0003	0.0003	CD
cord-023439-r04y1j22	105	30	]	]	-RRB-
cord-023439-r04y1j22	105	31	,	,	,
cord-023439-r04y1j22	105	32	and	and	CC
cord-023439-r04y1j22	105	33	even	even	RB
cord-023439-r04y1j22	105	34	when	when	WRB
cord-023439-r04y1j22	105	35	comparing	compare	VBG
cord-023439-r04y1j22	105	36	patients	patient	NNS
cord-023439-r04y1j22	105	37	with	with	IN
cord-023439-r04y1j22	105	38	identical	identical	JJ
cord-023439-r04y1j22	105	39	genotypes	genotype	NNS
cord-023439-r04y1j22	105	40	,	,	,
cord-023439-r04y1j22	105	41	serum	serum	NN
cord-023439-r04y1j22	105	42	MBL	MBL	NNP
cord-023439-r04y1j22	105	43	levels	level	NNS
cord-023439-r04y1j22	105	44	were	be	VBD
cord-023439-r04y1j22	105	45	higher	high	JJR
cord-023439-r04y1j22	105	46	in	in	IN
cord-023439-r04y1j22	105	47	the	the	DT
cord-023439-r04y1j22	105	48	nephropathy	nephropathy	NN
cord-023439-r04y1j22	105	49	group	group	NN
cord-023439-r04y1j22	105	50	than	than	IN
cord-023439-r04y1j22	105	51	in	in	IN
cord-023439-r04y1j22	105	52	the	the	DT
cord-023439-r04y1j22	105	53	normoalbuminuric	normoalbuminuric	NNP
cord-023439-r04y1j22	105	54	group	group	NN
cord-023439-r04y1j22	105	55	.	.	.
cord-023439-r04y1j22	106	1	Patients	patient	NNS
cord-023439-r04y1j22	106	2	with	with	IN
cord-023439-r04y1j22	106	3	a	a	DT
cord-023439-r04y1j22	106	4	history	history	NN
cord-023439-r04y1j22	106	5	of	of	IN
cord-023439-r04y1j22	106	6	cardiovascular	cardiovascular	JJ
cord-023439-r04y1j22	106	7	disease	disease	NN
cord-023439-r04y1j22	106	8	had	have	VBD
cord-023439-r04y1j22	106	9	significantly	significantly	RB
cord-023439-r04y1j22	106	10	elevated	elevate	VBN
cord-023439-r04y1j22	106	11	MBL	MBL	NNP
cord-023439-r04y1j22	106	12	levels	level	NNS
cord-023439-r04y1j22	106	13	independently	independently	RB
cord-023439-r04y1j22	106	14	of	of	IN
cord-023439-r04y1j22	106	15	nephropathy	nephropathy	NN
cord-023439-r04y1j22	106	16	status	status	NN
cord-023439-r04y1j22	106	17	[	[	-LRB-
cord-023439-r04y1j22	106	18	3178	3178	CD
cord-023439-r04y1j22	106	19	mg	mg	NNP
cord-023439-r04y1j22	106	20	/	/	SYM
cord-023439-r04y1j22	106	21	l	l	NN
cord-023439-r04y1j22	106	22	(	(	-LRB-
cord-023439-r04y1j22	106	23	IQR	IQR	NNP
cord-023439-r04y1j22	106	24	636	636	CD
cord-023439-r04y1j22	106	25	-	-	HYPH
cord-023439-r04y1j22	106	26	5231	5231	CD
cord-023439-r04y1j22	106	27	mg	mg	NNP
cord-023439-r04y1j22	106	28	/	/	SYM
cord-023439-r04y1j22	106	29	l	l	NNP
cord-023439-r04y1j22	106	30	)	)	-RRB-
cord-023439-r04y1j22	106	31	versus	versus	IN
cord-023439-r04y1j22	106	32	1741	1741	CD
cord-023439-r04y1j22	106	33	mg	mg	NNP
cord-023439-r04y1j22	106	34	/	/	SYM
cord-023439-r04y1j22	106	35	l	l	NN
cord-023439-r04y1j22	106	36	(	(	-LRB-
cord-023439-r04y1j22	106	37	IQR	IQR	NNP
cord-023439-r04y1j22	106	38	656	656	CD
cord-023439-r04y1j22	106	39	-	-	HYPH
cord-023439-r04y1j22	106	40	3149	3149	CD
cord-023439-r04y1j22	106	41	mg	mg	NNP
cord-023439-r04y1j22	106	42	/	/	SYM
cord-023439-r04y1j22	106	43	l	l	NNP
cord-023439-r04y1j22	106	44	)	)	-RRB-
cord-023439-r04y1j22	106	45	,	,	,
cord-023439-r04y1j22	106	46	P	p	NN
cord-023439-r04y1j22	106	47	¼	¼	CD
cord-023439-r04y1j22	106	48	0.02	0.02	CD
cord-023439-r04y1j22	106	49	]	]	-RRB-
cord-023439-r04y1j22	106	50	.	.	.
cord-023439-r04y1j22	107	1	The	the	DT
cord-023439-r04y1j22	107	2	differences	difference	NNS
cord-023439-r04y1j22	107	3	in	in	IN
cord-023439-r04y1j22	107	4	MBL	MBL	NNP
cord-023439-r04y1j22	107	5	levels	level	NNS
cord-023439-r04y1j22	107	6	between	between	IN
cord-023439-r04y1j22	107	7	patients	patient	NNS
cord-023439-r04y1j22	107	8	with	with	IN
cord-023439-r04y1j22	107	9	and	and	CC
cord-023439-r04y1j22	107	10	without	without	IN
cord-023439-r04y1j22	107	11	vascular	vascular	JJ
cord-023439-r04y1j22	107	12	complications	complication	NNS
cord-023439-r04y1j22	107	13	were	be	VBD
cord-023439-r04y1j22	107	14	driven	drive	VBN
cord-023439-r04y1j22	107	15	primarily	primarily	RB
cord-023439-r04y1j22	107	16	by	by	IN
cord-023439-r04y1j22	107	17	pronounced	pronounce	VBN
cord-023439-r04y1j22	107	18	differences	difference	NNS
cord-023439-r04y1j22	107	19	among	among	IN
cord-023439-r04y1j22	107	20	carriers	carrier	NNS
cord-023439-r04y1j22	107	21	of	of	IN
cord-023439-r04y1j22	107	22	high	high	JJ
cord-023439-r04y1j22	107	23	MBL	MBL	NNP
cord-023439-r04y1j22	107	24	genotypes	genotype	NNS
cord-023439-r04y1j22	107	25	(	(	-LRB-
cord-023439-r04y1j22	107	26	P	p	NN
cord-023439-r04y1j22	107	27	<	<	XX
cord-023439-r04y1j22	107	28	0.0001	0.0001	CD
cord-023439-r04y1j22	107	29	)	)	-RRB-
cord-023439-r04y1j22	107	30	.	.	.
cord-023439-r04y1j22	108	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	108	2	findings	finding	NNS
cord-023439-r04y1j22	108	3	suggest	suggest	VBP
cord-023439-r04y1j22	108	4	that	that	IN
cord-023439-r04y1j22	108	5	MBL	MBL	NNP
cord-023439-r04y1j22	108	6	may	may	MD
cord-023439-r04y1j22	108	7	be	be	VB
cord-023439-r04y1j22	108	8	involved	involve	VBN
cord-023439-r04y1j22	108	9	in	in	IN
cord-023439-r04y1j22	108	10	the	the	DT
cord-023439-r04y1j22	108	11	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	108	12	of	of	IN
cord-023439-r04y1j22	108	13	microvascular	microvascular	JJ
cord-023439-r04y1j22	108	14	and	and	CC
cord-023439-r04y1j22	108	15	macrovascular	macrovascular	JJ
cord-023439-r04y1j22	108	16	complications	complication	NNS
cord-023439-r04y1j22	108	17	in	in	IN
cord-023439-r04y1j22	108	18	type	type	NN
cord-023439-r04y1j22	108	19	1	1	CD
cord-023439-r04y1j22	108	20	diabetes	diabetes	NN
cord-023439-r04y1j22	108	21	and	and	CC
cord-023439-r04y1j22	108	22	that	that	DT
cord-023439-r04y1j22	108	23	determination	determination	NN
cord-023439-r04y1j22	108	24	of	of	IN
cord-023439-r04y1j22	108	25	MBL	MBL	NNP
cord-023439-r04y1j22	108	26	status	status	NN
cord-023439-r04y1j22	108	27	might	may	MD
cord-023439-r04y1j22	108	28	be	be	VB
cord-023439-r04y1j22	108	29	used	use	VBN
cord-023439-r04y1j22	108	30	to	to	TO
cord-023439-r04y1j22	108	31	identify	identify	VB
cord-023439-r04y1j22	108	32	patients	patient	NNS
cord-023439-r04y1j22	108	33	at	at	IN
cord-023439-r04y1j22	108	34	increased	increase	VBN
cord-023439-r04y1j22	108	35	risk	risk	NN
cord-023439-r04y1j22	108	36	of	of	IN
cord-023439-r04y1j22	108	37	developing	develop	VBG
cord-023439-r04y1j22	108	38	these	these	DT
cord-023439-r04y1j22	108	39	complications	complication	NNS
cord-023439-r04y1j22	108	40	.	.	.
cord-023439-r04y1j22	109	1	Neuroimmunology	Neuroimmunology	NNP
cord-023439-r04y1j22	109	2	Unit	Unit	NNP
cord-023439-r04y1j22	109	3	,	,	,
cord-023439-r04y1j22	109	4	Center	Center	NNP
cord-023439-r04y1j22	109	5	for	for	IN
cord-023439-r04y1j22	109	6	Molecular	Molecular	NNP
cord-023439-r04y1j22	109	7	Medicine	Medicine	NNP
cord-023439-r04y1j22	109	8	,	,	,
cord-023439-r04y1j22	109	9	Karolinska	Karolinska	NNP
cord-023439-r04y1j22	109	10	Institutet	Institutet	NNP
cord-023439-r04y1j22	109	11	,	,	,
cord-023439-r04y1j22	109	12	Stockholm	Stockholm	NNP
cord-023439-r04y1j22	109	13	,	,	,
cord-023439-r04y1j22	109	14	Sweden	Sweden	NNP
cord-023439-r04y1j22	109	15	.	.	.
cord-023439-r04y1j22	110	1	E	e	NN
cord-023439-r04y1j22	110	2	-	-	NN
cord-023439-r04y1j22	110	3	mail	mail	NN
cord-023439-r04y1j22	110	4	:	:	:
cord-023439-r04y1j22	111	1	judit.wefer@cmm.ki.se	judit.wefer@cmm.ki.se	JJ
cord-023439-r04y1j22	111	2	DNA	dna	NN
cord-023439-r04y1j22	111	3	vaccine	vaccine	NN
cord-023439-r04y1j22	111	4	coding	code	VBG
cord-023439-r04y1j22	111	5	for	for	IN
cord-023439-r04y1j22	111	6	the	the	DT
cord-023439-r04y1j22	111	7	encephalitogenic	encephalitogenic	NNP
cord-023439-r04y1j22	111	8	peptide	peptide	NN
cord-023439-r04y1j22	111	9	MOG	MOG	NNP
cord-023439-r04y1j22	111	10	91	91	CD
cord-023439-r04y1j22	111	11	-	-	HYPH
cord-023439-r04y1j22	111	12	108	108	CD
cord-023439-r04y1j22	111	13	protects	protect	VBZ
cord-023439-r04y1j22	111	14	LEW.1AV1	lew.1av1	RB
cord-023439-r04y1j22	111	15	from	from	IN
cord-023439-r04y1j22	111	16	subsequent	subsequent	JJ
cord-023439-r04y1j22	111	17	development	development	NN
cord-023439-r04y1j22	111	18	of	of	IN
cord-023439-r04y1j22	111	19	experimental	experimental	JJ
cord-023439-r04y1j22	111	20	autoimmune	autoimmune	JJ
cord-023439-r04y1j22	111	21	encephalomyelitis	encephalomyelitis	NN
cord-023439-r04y1j22	111	22	(	(	-LRB-
cord-023439-r04y1j22	111	23	EAE	EAE	NNP
cord-023439-r04y1j22	111	24	)	)	-RRB-
cord-023439-r04y1j22	111	25	.	.	.
cord-023439-r04y1j22	112	1	Protection	protection	NN
cord-023439-r04y1j22	112	2	is	be	VBZ
cord-023439-r04y1j22	112	3	associated	associate	VBN
cord-023439-r04y1j22	112	4	with	with	IN
cord-023439-r04y1j22	112	5	a	a	DT
cord-023439-r04y1j22	112	6	type	type	NN
cord-023439-r04y1j22	112	7	1	1	CD
cord-023439-r04y1j22	112	8	immune	immune	JJ
cord-023439-r04y1j22	112	9	response	response	NN
cord-023439-r04y1j22	112	10	and	and	CC
cord-023439-r04y1j22	112	11	is	be	VBZ
cord-023439-r04y1j22	112	12	dependent	dependent	JJ
cord-023439-r04y1j22	112	13	on	on	IN
cord-023439-r04y1j22	112	14	the	the	DT
cord-023439-r04y1j22	112	15	presence	presence	NN
cord-023439-r04y1j22	112	16	of	of	IN
cord-023439-r04y1j22	112	17	CpG	CpG	NNP
cord-023439-r04y1j22	112	18	DNA	DNA	NNP
cord-023439-r04y1j22	112	19	motifs	motif	NNS
cord-023439-r04y1j22	112	20	.	.	.
cord-023439-r04y1j22	113	1	The	the	DT
cord-023439-r04y1j22	113	2	mechanisms	mechanism	NNS
cord-023439-r04y1j22	113	3	underlying	underlie	VBG
cord-023439-r04y1j22	113	4	the	the	DT
cord-023439-r04y1j22	113	5	observed	observed	JJ
cord-023439-r04y1j22	113	6	reduction	reduction	NN
cord-023439-r04y1j22	113	7	of	of	IN
cord-023439-r04y1j22	113	8	EAE	EAE	NNP
cord-023439-r04y1j22	113	9	development	development	NN
cord-023439-r04y1j22	113	10	in	in	IN
cord-023439-r04y1j22	113	11	protected	protect	VBN
cord-023439-r04y1j22	113	12	rats	rat	NNS
cord-023439-r04y1j22	113	13	have	have	VBP
cord-023439-r04y1j22	113	14	not	not	RB
cord-023439-r04y1j22	113	15	been	be	VBN
cord-023439-r04y1j22	113	16	fully	fully	RB
cord-023439-r04y1j22	113	17	clarified	clarify	VBN
cord-023439-r04y1j22	113	18	.	.	.
cord-023439-r04y1j22	114	1	We	-PRON-	PRP
cord-023439-r04y1j22	114	2	investigated	investigate	VBD
cord-023439-r04y1j22	114	3	immunological	immunological	JJ
cord-023439-r04y1j22	114	4	characteristics	characteristic	NNS
cord-023439-r04y1j22	114	5	of	of	IN
cord-023439-r04y1j22	114	6	lymphocytes	lymphocyte	NNS
cord-023439-r04y1j22	114	7	after	after	IN
cord-023439-r04y1j22	114	8	DNA	dna	NN
cord-023439-r04y1j22	114	9	vaccinaton	vaccinaton	NN
cord-023439-r04y1j22	114	10	and	and	CC
cord-023439-r04y1j22	114	11	subsequent	subsequent	JJ
cord-023439-r04y1j22	114	12	EAE	EAE	NNP
cord-023439-r04y1j22	114	13	induction	induction	NN
cord-023439-r04y1j22	114	14	.	.	.
cord-023439-r04y1j22	115	1	We	-PRON-	PRP
cord-023439-r04y1j22	115	2	confirm	confirm	VBP
cord-023439-r04y1j22	115	3	that	that	IN
cord-023439-r04y1j22	115	4	protection	protection	NN
cord-023439-r04y1j22	115	5	was	be	VBD
cord-023439-r04y1j22	115	6	not	not	RB
cord-023439-r04y1j22	115	7	associated	associate	VBN
cord-023439-r04y1j22	115	8	with	with	IN
cord-023439-r04y1j22	115	9	suppression	suppression	NN
cord-023439-r04y1j22	115	10	of	of	IN
cord-023439-r04y1j22	115	11	T1	t1	NN
cord-023439-r04y1j22	115	12	cells	cell	NNS
cord-023439-r04y1j22	115	13	,	,	,
cord-023439-r04y1j22	115	14	as	as	IN
cord-023439-r04y1j22	115	15	transcription	transcription	NN
cord-023439-r04y1j22	115	16	of	of	IN
cord-023439-r04y1j22	115	17	the	the	DT
cord-023439-r04y1j22	115	18	novel	novel	JJ
cord-023439-r04y1j22	115	19	molecule	molecule	NN
cord-023439-r04y1j22	115	20	rat	rat	NN
cord-023439-r04y1j22	115	21	T	t	NN
cord-023439-r04y1j22	115	22	-	-	HYPH
cord-023439-r04y1j22	115	23	cell	cell	NN
cord-023439-r04y1j22	115	24	immunoglobulin	immunoglobulin	NN
cord-023439-r04y1j22	115	25	-	-	:
cord-023439-r04y1j22	115	26	and	and	CC
cord-023439-r04y1j22	115	27	mucindomain	mucindomain	NN
cord-023439-r04y1j22	115	28	-	-	HYPH
cord-023439-r04y1j22	115	29	containing	contain	VBG
cord-023439-r04y1j22	115	30	molecule	molecule	NN
cord-023439-r04y1j22	115	31	(	(	-LRB-
cord-023439-r04y1j22	115	32	TIM-3	TIM-3	NNP
cord-023439-r04y1j22	115	33	)	)	-RRB-
cord-023439-r04y1j22	115	34	,	,	,
cord-023439-r04y1j22	115	35	reported	report	VBN
cord-023439-r04y1j22	115	36	to	to	TO
cord-023439-r04y1j22	115	37	be	be	VB
cord-023439-r04y1j22	115	38	exclusively	exclusively	RB
cord-023439-r04y1j22	115	39	expressed	express	VBN
cord-023439-r04y1j22	115	40	on	on	IN
cord-023439-r04y1j22	115	41	differentiated	differentiate	VBN
cord-023439-r04y1j22	115	42	T1	t1	NN
cord-023439-r04y1j22	115	43	cells	cell	NNS
cord-023439-r04y1j22	115	44	,	,	,
cord-023439-r04y1j22	115	45	was	be	VBD
cord-023439-r04y1j22	115	46	not	not	RB
cord-023439-r04y1j22	115	47	altered	alter	VBN
cord-023439-r04y1j22	115	48	by	by	IN
cord-023439-r04y1j22	115	49	DNA	dna	NN
cord-023439-r04y1j22	115	50	vaccination	vaccination	NN
cord-023439-r04y1j22	115	51	.	.	.
cord-023439-r04y1j22	116	1	We	-PRON-	PRP
cord-023439-r04y1j22	116	2	did	do	VBD
cord-023439-r04y1j22	116	3	not	not	RB
cord-023439-r04y1j22	116	4	note	note	VB
cord-023439-r04y1j22	116	5	any	any	DT
cord-023439-r04y1j22	116	6	clonal	clonal	JJ
cord-023439-r04y1j22	116	7	deletion	deletion	NN
cord-023439-r04y1j22	116	8	upon	upon	IN
cord-023439-r04y1j22	116	9	tolerization	tolerization	NN
cord-023439-r04y1j22	116	10	,	,	,
cord-023439-r04y1j22	116	11	but	but	CC
cord-023439-r04y1j22	116	12	detected	detect	VBD
cord-023439-r04y1j22	116	13	an	an	DT
cord-023439-r04y1j22	116	14	antigen	antigen	NN
cord-023439-r04y1j22	116	15	-	-	HYPH
cord-023439-r04y1j22	116	16	specific	specific	JJ
cord-023439-r04y1j22	116	17	lymphocyte	lymphocyte	NN
cord-023439-r04y1j22	116	18	population	population	NN
cord-023439-r04y1j22	116	19	upregulating	upregulate	VBG
cord-023439-r04y1j22	116	20	IFNg	IFNg	NNS
cord-023439-r04y1j22	116	21	upon	upon	IN
cord-023439-r04y1j22	116	22	recall	recall	NN
cord-023439-r04y1j22	116	23	stimulation	stimulation	NN
cord-023439-r04y1j22	116	24	3	3	CD
cord-023439-r04y1j22	116	25	weeks	week	NNS
cord-023439-r04y1j22	116	26	after	after	IN
cord-023439-r04y1j22	116	27	protective	protective	JJ
cord-023439-r04y1j22	116	28	DNA	dna	NN
cord-023439-r04y1j22	116	29	vaccination	vaccination	NN
cord-023439-r04y1j22	116	30	.	.	.
cord-023439-r04y1j22	117	1	In	in	IN
cord-023439-r04y1j22	117	2	protected	protect	VBN
cord-023439-r04y1j22	117	3	rats	rat	NNS
cord-023439-r04y1j22	117	4	,	,	,
cord-023439-r04y1j22	117	5	we	-PRON-	PRP
cord-023439-r04y1j22	117	6	observed	observe	VBD
cord-023439-r04y1j22	117	7	(	(	-LRB-
cord-023439-r04y1j22	117	8	1	1	LS
cord-023439-r04y1j22	117	9	)	)	-RRB-
cord-023439-r04y1j22	117	10	no	no	DT
cord-023439-r04y1j22	117	11	alterations	alteration	NNS
cord-023439-r04y1j22	117	12	in	in	IN
cord-023439-r04y1j22	117	13	antigenspecific	antigenspecific	NN
cord-023439-r04y1j22	117	14	Th2	th2	CD
cord-023439-r04y1j22	117	15	or	or	CC
cord-023439-r04y1j22	117	16	Th3	th3	JJ
cord-023439-r04y1j22	117	17	responses	response	NNS
cord-023439-r04y1j22	117	18	,	,	,
cord-023439-r04y1j22	117	19	(	(	-LRB-
cord-023439-r04y1j22	117	20	2	2	LS
cord-023439-r04y1j22	117	21	)	)	-RRB-
cord-023439-r04y1j22	117	22	reduced	reduce	VBN
cord-023439-r04y1j22	117	23	MHC	MHC	NNP
cord-023439-r04y1j22	117	24	II	II	NNP
cord-023439-r04y1j22	117	25	expression	expression	NN
cord-023439-r04y1j22	117	26	on	on	IN
cord-023439-r04y1j22	117	27	splenocytes	splenocytes	NNP
cord-023439-r04y1j22	117	28	early	early	RB
cord-023439-r04y1j22	117	29	after	after	IN
cord-023439-r04y1j22	117	30	EAE	EAE	NNP
cord-023439-r04y1j22	117	31	induction	induction	NN
cord-023439-r04y1j22	117	32	,	,	,
cord-023439-r04y1j22	117	33	(	(	-LRB-
cord-023439-r04y1j22	117	34	3	3	LS
cord-023439-r04y1j22	117	35	)	)	-RRB-
cord-023439-r04y1j22	117	36	antigen	antigen	NN
cord-023439-r04y1j22	117	37	-	-	HYPH
cord-023439-r04y1j22	117	38	specific	specific	JJ
cord-023439-r04y1j22	117	39	upregulation	upregulation	NN
cord-023439-r04y1j22	117	40	of	of	IN
cord-023439-r04y1j22	117	41	IFNb	IFNb	NNS
cord-023439-r04y1j22	117	42	upon	upon	IN
cord-023439-r04y1j22	117	43	recall	recall	VBP
cord-023439-r04y1j22	117	44	stimulation	stimulation	NN
cord-023439-r04y1j22	117	45	and	and	CC
cord-023439-r04y1j22	117	46	(	(	-LRB-
cord-023439-r04y1j22	117	47	4	4	LS
cord-023439-r04y1j22	117	48	)	)	-RRB-
cord-023439-r04y1j22	117	49	reduced	reduce	VBN
cord-023439-r04y1j22	117	50	IL-12Rb2	il-12rb2	NN
cord-023439-r04y1j22	117	51	on	on	IN
cord-023439-r04y1j22	117	52	lymphocytes	lymphocyte	NNS
cord-023439-r04y1j22	117	53	.	.	.
cord-023439-r04y1j22	118	1	We	-PRON-	PRP
cord-023439-r04y1j22	118	2	thus	thus	RB
cord-023439-r04y1j22	118	3	demonstrate	demonstrate	VBP
cord-023439-r04y1j22	118	4	an	an	DT
cord-023439-r04y1j22	118	5	association	association	NN
cord-023439-r04y1j22	118	6	of	of	IN
cord-023439-r04y1j22	118	7	the	the	DT
cord-023439-r04y1j22	118	8	protective	protective	JJ
cord-023439-r04y1j22	118	9	effect	effect	NN
cord-023439-r04y1j22	118	10	of	of	IN
cord-023439-r04y1j22	118	11	DNA	dna	NN
cord-023439-r04y1j22	118	12	vaccination	vaccination	NN
cord-023439-r04y1j22	118	13	with	with	IN
cord-023439-r04y1j22	118	14	expression	expression	NN
cord-023439-r04y1j22	118	15	of	of	IN
cord-023439-r04y1j22	118	16	IFNb	IFNb	NNS
cord-023439-r04y1j22	118	17	.	.	.
cord-023439-r04y1j22	119	1	We	-PRON-	PRP
cord-023439-r04y1j22	119	2	are	be	VBP
cord-023439-r04y1j22	119	3	currently	currently	RB
cord-023439-r04y1j22	119	4	investigating	investigate	VBG
cord-023439-r04y1j22	119	5	the	the	DT
cord-023439-r04y1j22	119	6	cellular	cellular	JJ
cord-023439-r04y1j22	119	7	mechanisms	mechanism	NNS
cord-023439-r04y1j22	119	8	behind	behind	IN
cord-023439-r04y1j22	119	9	this	this	DT
cord-023439-r04y1j22	119	10	IFNb	IFNb	NNS
cord-023439-r04y1j22	119	11	-	-	HYPH
cord-023439-r04y1j22	119	12	mediated	mediate	VBN
cord-023439-r04y1j22	119	13	protection	protection	NN
cord-023439-r04y1j22	119	14	.	.	.
cord-023439-r04y1j22	120	1	Multiple	multiple	JJ
cord-023439-r04y1j22	120	2	sclerosis	sclerosis	NN
cord-023439-r04y1j22	120	3	(	(	-LRB-
cord-023439-r04y1j22	120	4	MS	MS	NNP
cord-023439-r04y1j22	120	5	)	)	-RRB-
cord-023439-r04y1j22	120	6	is	be	VBZ
cord-023439-r04y1j22	120	7	an	an	DT
cord-023439-r04y1j22	120	8	autoimmune	autoimmune	JJ
cord-023439-r04y1j22	120	9	condition	condition	NN
cord-023439-r04y1j22	120	10	characterized	characterize	VBN
cord-023439-r04y1j22	120	11	by	by	IN
cord-023439-r04y1j22	120	12	degeneration	degeneration	NN
cord-023439-r04y1j22	120	13	of	of	IN
cord-023439-r04y1j22	120	14	nerve	nerve	NN
cord-023439-r04y1j22	120	15	fibre	fibre	NN
cord-023439-r04y1j22	120	16	myelin	myelin	NN
cord-023439-r04y1j22	120	17	sheets	sheet	NNS
cord-023439-r04y1j22	120	18	.	.	.
cord-023439-r04y1j22	121	1	A	a	DT
cord-023439-r04y1j22	121	2	candidate	candidate	NN
cord-023439-r04y1j22	121	3	autoantigen	autoantigen	NN
cord-023439-r04y1j22	121	4	,	,	,
cord-023439-r04y1j22	121	5	myelin	myelin	JJ
cord-023439-r04y1j22	121	6	basic	basic	JJ
cord-023439-r04y1j22	121	7	protein	protein	NN
cord-023439-r04y1j22	121	8	(	(	-LRB-
cord-023439-r04y1j22	121	9	MBP	MBP	NNP
cord-023439-r04y1j22	121	10	)	)	-RRB-
cord-023439-r04y1j22	121	11	,	,	,
cord-023439-r04y1j22	121	12	has	have	VBZ
cord-023439-r04y1j22	121	13	especially	especially	RB
cord-023439-r04y1j22	121	14	attracted	attract	VBN
cord-023439-r04y1j22	121	15	attention	attention	NN
cord-023439-r04y1j22	121	16	.	.	.
cord-023439-r04y1j22	122	1	The	the	DT
cord-023439-r04y1j22	122	2	presence	presence	NN
cord-023439-r04y1j22	122	3	of	of	IN
cord-023439-r04y1j22	122	4	anti	anti	JJ
cord-023439-r04y1j22	122	5	-	-	JJ
cord-023439-r04y1j22	122	6	MBP	mbp	JJ
cord-023439-r04y1j22	122	7	antibodies	antibody	NNS
cord-023439-r04y1j22	122	8	is	be	VBZ
cord-023439-r04y1j22	122	9	a	a	DT
cord-023439-r04y1j22	122	10	predictor	predictor	NN
cord-023439-r04y1j22	122	11	of	of	IN
cord-023439-r04y1j22	122	12	definite	definite	JJ
cord-023439-r04y1j22	122	13	MS	MS	NNP
cord-023439-r04y1j22	122	14	,	,	,
cord-023439-r04y1j22	122	15	but	but	CC
cord-023439-r04y1j22	122	16	their	-PRON-	PRP$
cord-023439-r04y1j22	122	17	role	role	NN
cord-023439-r04y1j22	122	18	in	in	IN
cord-023439-r04y1j22	122	19	the	the	DT
cord-023439-r04y1j22	122	20	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	122	21	remains	remain	VBZ
cord-023439-r04y1j22	122	22	obscure	obscure	JJ
cord-023439-r04y1j22	122	23	.	.	.
cord-023439-r04y1j22	123	1	T	t	NN
cord-023439-r04y1j22	123	2	cells	cell	NNS
cord-023439-r04y1j22	123	3	have	have	VBP
cord-023439-r04y1j22	123	4	long	long	RB
cord-023439-r04y1j22	123	5	been	be	VBN
cord-023439-r04y1j22	123	6	known	know	VBN
cord-023439-r04y1j22	123	7	to	to	TO
cord-023439-r04y1j22	123	8	play	play	VB
cord-023439-r04y1j22	123	9	a	a	DT
cord-023439-r04y1j22	123	10	pivotal	pivotal	JJ
cord-023439-r04y1j22	123	11	role	role	NN
cord-023439-r04y1j22	123	12	in	in	IN
cord-023439-r04y1j22	123	13	the	the	DT
cord-023439-r04y1j22	123	14	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	123	15	of	of	IN
cord-023439-r04y1j22	123	16	MS	MS	NNP
cord-023439-r04y1j22	123	17	.	.	.
cord-023439-r04y1j22	124	1	Recently	recently	RB
cord-023439-r04y1j22	124	2	,	,	,
cord-023439-r04y1j22	124	3	an	an	DT
cord-023439-r04y1j22	124	4	important	important	JJ
cord-023439-r04y1j22	124	5	role	role	NN
cord-023439-r04y1j22	124	6	for	for	IN
cord-023439-r04y1j22	124	7	B	b	NN
cord-023439-r04y1j22	124	8	cells	cell	NNS
cord-023439-r04y1j22	124	9	as	as	IN
cord-023439-r04y1j22	124	10	autoantigen	autoantigen	NN
cord-023439-r04y1j22	124	11	-	-	HYPH
cord-023439-r04y1j22	124	12	presenting	present	VBG
cord-023439-r04y1j22	124	13	cells	cell	NNS
cord-023439-r04y1j22	124	14	has	have	VBZ
cord-023439-r04y1j22	124	15	been	be	VBN
cord-023439-r04y1j22	124	16	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	124	17	in	in	IN
cord-023439-r04y1j22	124	18	other	other	JJ
cord-023439-r04y1j22	124	19	autoimmune	autoimmune	JJ
cord-023439-r04y1j22	124	20	diseases	disease	NNS
cord-023439-r04y1j22	124	21	,	,	,
cord-023439-r04y1j22	124	22	including	include	VBG
cord-023439-r04y1j22	124	23	rheumatoid	rheumatoid	NN
cord-023439-r04y1j22	124	24	arthritis	arthritis	NN
cord-023439-r04y1j22	124	25	and	and	CC
cord-023439-r04y1j22	124	26	diabetes	diabetes	NN
cord-023439-r04y1j22	124	27	.	.	.
cord-023439-r04y1j22	125	1	The	the	DT
cord-023439-r04y1j22	125	2	uptake	uptake	NN
cord-023439-r04y1j22	125	3	of	of	IN
cord-023439-r04y1j22	125	4	MBP	MBP	NNP
cord-023439-r04y1j22	125	5	by	by	IN
cord-023439-r04y1j22	125	6	B	b	NN
cord-023439-r04y1j22	125	7	cells	cell	NNS
cord-023439-r04y1j22	125	8	and	and	CC
cord-023439-r04y1j22	125	9	the	the	DT
cord-023439-r04y1j22	125	10	presentation	presentation	NN
cord-023439-r04y1j22	125	11	of	of	IN
cord-023439-r04y1j22	125	12	MBP	MBP	NNP
cord-023439-r04y1j22	125	13	-	-	HYPH
cord-023439-r04y1j22	125	14	derive	derive	VBP
cord-023439-r04y1j22	125	15	peptides	peptide	NNS
cord-023439-r04y1j22	125	16	to	to	IN
cord-023439-r04y1j22	125	17	T	T	NNP
cord-023439-r04y1j22	125	18	helper	helper	NN
cord-023439-r04y1j22	125	19	(	(	-LRB-
cord-023439-r04y1j22	125	20	Th	Th	NNP
cord-023439-r04y1j22	125	21	)	)	-RRB-
cord-023439-r04y1j22	125	22	cells	cell	NNS
cord-023439-r04y1j22	125	23	by	by	IN
cord-023439-r04y1j22	125	24	B	b	NN
cord-023439-r04y1j22	125	25	cells	cell	NNS
cord-023439-r04y1j22	125	26	may	may	MD
cord-023439-r04y1j22	125	27	be	be	VB
cord-023439-r04y1j22	125	28	promoted	promote	VBN
cord-023439-r04y1j22	125	29	by	by	IN
cord-023439-r04y1j22	125	30	the	the	DT
cord-023439-r04y1j22	125	31	formation	formation	NN
cord-023439-r04y1j22	125	32	of	of	IN
cord-023439-r04y1j22	125	33	complement	complement	NN
cord-023439-r04y1j22	125	34	(	(	-LRB-
cord-023439-r04y1j22	125	35	C	c	NN
cord-023439-r04y1j22	125	36	)	)	-RRB-
cord-023439-r04y1j22	125	37	activating	activate	VBG
cord-023439-r04y1j22	125	38	immune	immune	JJ
cord-023439-r04y1j22	125	39	complexes	complex	NNS
cord-023439-r04y1j22	125	40	(	(	-LRB-
cord-023439-r04y1j22	125	41	ICs	ICs	NNP
cord-023439-r04y1j22	125	42	)	)	-RRB-
cord-023439-r04y1j22	125	43	between	between	IN
cord-023439-r04y1j22	125	44	MBP	MBP	NNP
cord-023439-r04y1j22	125	45	and	and	CC
cord-023439-r04y1j22	125	46	natural	natural	JJ
cord-023439-r04y1j22	125	47	autoantibodies	autoantibody	NNS
cord-023439-r04y1j22	125	48	in	in	IN
cord-023439-r04y1j22	125	49	healthy	healthy	JJ
cord-023439-r04y1j22	125	50	individuals	individual	NNS
cord-023439-r04y1j22	125	51	and	and	CC
cord-023439-r04y1j22	125	52	disease	disease	NN
cord-023439-r04y1j22	125	53	-	-	HYPH
cord-023439-r04y1j22	125	54	associated	associate	VBN
cord-023439-r04y1j22	125	55	anti	anti	JJ
cord-023439-r04y1j22	125	56	-	-	JJ
cord-023439-r04y1j22	125	57	MBP	mbp	JJ
cord-023439-r04y1j22	125	58	antibodies	antibody	NNS
cord-023439-r04y1j22	125	59	in	in	IN
cord-023439-r04y1j22	125	60	MS	MS	NNP
cord-023439-r04y1j22	125	61	patients	patient	NNS
cord-023439-r04y1j22	125	62	,	,	,
cord-023439-r04y1j22	125	63	respectively	respectively	RB
cord-023439-r04y1j22	125	64	.	.	.
cord-023439-r04y1j22	126	1	We	-PRON-	PRP
cord-023439-r04y1j22	126	2	have	have	VBP
cord-023439-r04y1j22	126	3	investigated	investigate	VBN
cord-023439-r04y1j22	126	4	the	the	DT
cord-023439-r04y1j22	126	5	formation	formation	NN
cord-023439-r04y1j22	126	6	of	of	IN
cord-023439-r04y1j22	126	7	MBP	MBP	NNP
cord-023439-r04y1j22	126	8	-	-	HYPH
cord-023439-r04y1j22	126	9	containing	contain	VBG
cord-023439-r04y1j22	126	10	IC	IC	NNP
cord-023439-r04y1j22	126	11	,	,	,
cord-023439-r04y1j22	126	12	the	the	DT
cord-023439-r04y1j22	126	13	binding	binding	NN
cord-023439-r04y1j22	126	14	of	of	IN
cord-023439-r04y1j22	126	15	MBP	MBP	NNP
cord-023439-r04y1j22	126	16	to	to	IN
cord-023439-r04y1j22	126	17	B	b	NN
cord-023439-r04y1j22	126	18	cells	cell	NNS
cord-023439-r04y1j22	126	19	,	,	,
cord-023439-r04y1j22	126	20	the	the	DT
cord-023439-r04y1j22	126	21	MBP	MBP	NNP
cord-023439-r04y1j22	126	22	-	-	HYPH
cord-023439-r04y1j22	126	23	elicited	elicit	VBN
cord-023439-r04y1j22	126	24	induction	induction	NN
cord-023439-r04y1j22	126	25	of	of	IN
cord-023439-r04y1j22	126	26	Th	Th	NNP
cord-023439-r04y1j22	126	27	-	-	HYPH
cord-023439-r04y1j22	126	28	cell	cell	NN
cord-023439-r04y1j22	126	29	and	and	CC
cord-023439-r04y1j22	126	30	B	b	NN
cord-023439-r04y1j22	126	31	-	-	HYPH
cord-023439-r04y1j22	126	32	cell	cell	NN
cord-023439-r04y1j22	126	33	proliferation	proliferation	NN
cord-023439-r04y1j22	126	34	and	and	CC
cord-023439-r04y1j22	126	35	the	the	DT
cord-023439-r04y1j22	126	36	cytokine	cytokine	NN
cord-023439-r04y1j22	126	37	production	production	NN
cord-023439-r04y1j22	126	38	in	in	IN
cord-023439-r04y1j22	126	39	peripheral	peripheral	JJ
cord-023439-r04y1j22	126	40	blood	blood	NN
cord-023439-r04y1j22	126	41	mononuclear	mononuclear	NN
cord-023439-r04y1j22	126	42	cells	cell	NNS
cord-023439-r04y1j22	126	43	(	(	-LRB-
cord-023439-r04y1j22	126	44	PBMCs	pbmc	NNS
cord-023439-r04y1j22	126	45	)	)	-RRB-
cord-023439-r04y1j22	126	46	from	from	IN
cord-023439-r04y1j22	126	47	healthy	healthy	JJ
cord-023439-r04y1j22	126	48	donors	donor	NNS
cord-023439-r04y1j22	126	49	grown	grow	VBN
cord-023439-r04y1j22	126	50	in	in	IN
cord-023439-r04y1j22	126	51	the	the	DT
cord-023439-r04y1j22	126	52	presence	presence	NN
cord-023439-r04y1j22	126	53	of	of	IN
cord-023439-r04y1j22	126	54	intact	intact	JJ
cord-023439-r04y1j22	126	55	or	or	CC
cord-023439-r04y1j22	126	56	C	c	NN
cord-023439-r04y1j22	126	57	-	-	HYPH
cord-023439-r04y1j22	126	58	inactivated	inactivate	VBN
cord-023439-r04y1j22	126	59	serum	serum	NN
cord-023439-r04y1j22	126	60	from	from	IN
cord-023439-r04y1j22	126	61	healthy	healthy	JJ
cord-023439-r04y1j22	126	62	donors	donor	NNS
cord-023439-r04y1j22	126	63	or	or	CC
cord-023439-r04y1j22	126	64	patients	patient	NNS
cord-023439-r04y1j22	126	65	with	with	IN
cord-023439-r04y1j22	126	66	MS	MS	NNP
cord-023439-r04y1j22	126	67	.	.	.
cord-023439-r04y1j22	127	1	While	while	IN
cord-023439-r04y1j22	127	2	MBP	MBP	NNP
cord-023439-r04y1j22	127	3	did	do	VBD
cord-023439-r04y1j22	127	4	not	not	RB
cord-023439-r04y1j22	127	5	induce	induce	VB
cord-023439-r04y1j22	127	6	measurable	measurable	JJ
cord-023439-r04y1j22	127	7	proliferation	proliferation	NN
cord-023439-r04y1j22	127	8	of	of	IN
cord-023439-r04y1j22	127	9	B	b	NN
cord-023439-r04y1j22	127	10	cells	cell	NNS
cord-023439-r04y1j22	127	11	nor	nor	CC
cord-023439-r04y1j22	127	12	CD4	CD4	NNP
cord-023439-r04y1j22	127	13	þ	þ	NNP
cord-023439-r04y1j22	127	14	T	t	NN
cord-023439-r04y1j22	127	15	cells	cell	NNS
cord-023439-r04y1j22	127	16	,	,	,
cord-023439-r04y1j22	127	17	we	-PRON-	PRP
cord-023439-r04y1j22	127	18	observed	observe	VBD
cord-023439-r04y1j22	127	19	the	the	DT
cord-023439-r04y1j22	127	20	production	production	NN
cord-023439-r04y1j22	127	21	of	of	IN
cord-023439-r04y1j22	127	22	TNF	TNF	NNP
cord-023439-r04y1j22	127	23	-	-	HYPH
cord-023439-r04y1j22	127	24	a	a	NNP
cord-023439-r04y1j22	127	25	,	,	,
cord-023439-r04y1j22	127	26	IFN	IFN	NNP
cord-023439-r04y1j22	127	27	-	-	HYPH
cord-023439-r04y1j22	127	28	g	g	NNP
cord-023439-r04y1j22	127	29	and	and	CC
cord-023439-r04y1j22	127	30	IL-10	IL-10	NNP
cord-023439-r04y1j22	127	31	by	by	IN
cord-023439-r04y1j22	127	32	PBMC	PBMC	NNP
cord-023439-r04y1j22	127	33	in	in	IN
cord-023439-r04y1j22	127	34	response	response	NN
cord-023439-r04y1j22	127	35	to	to	IN
cord-023439-r04y1j22	127	36	incubation	incubation	NN
cord-023439-r04y1j22	127	37	with	with	IN
cord-023439-r04y1j22	127	38	MBP	MBP	NNP
cord-023439-r04y1j22	127	39	in	in	IN
cord-023439-r04y1j22	127	40	the	the	DT
cord-023439-r04y1j22	127	41	presence	presence	NN
cord-023439-r04y1j22	127	42	of	of	IN
cord-023439-r04y1j22	127	43	sera	sera	NNP
cord-023439-r04y1j22	127	44	from	from	IN
cord-023439-r04y1j22	127	45	healthy	healthy	JJ
cord-023439-r04y1j22	127	46	controls	control	NNS
cord-023439-r04y1j22	127	47	as	as	RB
cord-023439-r04y1j22	127	48	well	well	RB
cord-023439-r04y1j22	127	49	as	as	IN
cord-023439-r04y1j22	127	50	sera	sera	NNP
cord-023439-r04y1j22	127	51	from	from	IN
cord-023439-r04y1j22	127	52	MS	MS	NNP
cord-023439-r04y1j22	127	53	patients	patient	NNS
cord-023439-r04y1j22	127	54	.	.	.
cord-023439-r04y1j22	128	1	By	by	IN
cord-023439-r04y1j22	128	2	contrast	contrast	NN
cord-023439-r04y1j22	128	3	,	,	,
cord-023439-r04y1j22	128	4	no	no	DT
cord-023439-r04y1j22	128	5	production	production	NN
cord-023439-r04y1j22	128	6	of	of	IN
cord-023439-r04y1j22	128	7	IL-2	IL-2	NNP
cord-023439-r04y1j22	128	8	,	,	,
cord-023439-r04y1j22	128	9	IL-4	IL-4	NNP
cord-023439-r04y1j22	128	10	and	and	CC
cord-023439-r04y1j22	128	11	IL-5	IL-5	NNP
cord-023439-r04y1j22	128	12	was	be	VBD
cord-023439-r04y1j22	128	13	detected	detect	VBN
cord-023439-r04y1j22	128	14	.	.	.
cord-023439-r04y1j22	129	1	We	-PRON-	PRP
cord-023439-r04y1j22	129	2	are	be	VBP
cord-023439-r04y1j22	129	3	currently	currently	RB
cord-023439-r04y1j22	129	4	investigating	investigate	VBG
cord-023439-r04y1j22	129	5	the	the	DT
cord-023439-r04y1j22	129	6	capability	capability	NN
cord-023439-r04y1j22	129	7	of	of	IN
cord-023439-r04y1j22	129	8	MS	MS	NNP
cord-023439-r04y1j22	129	9	sera	sera	NNP
cord-023439-r04y1j22	129	10	to	to	TO
cord-023439-r04y1j22	129	11	promote	promote	VB
cord-023439-r04y1j22	129	12	the	the	DT
cord-023439-r04y1j22	129	13	formation	formation	NN
cord-023439-r04y1j22	129	14	of	of	IN
cord-023439-r04y1j22	129	15	MBP	MBP	NNP
cord-023439-r04y1j22	129	16	-	-	HYPH
cord-023439-r04y1j22	129	17	containing	contain	VBG
cord-023439-r04y1j22	129	18	IC	IC	NNP
cord-023439-r04y1j22	129	19	and	and	CC
cord-023439-r04y1j22	129	20	thereby	thereby	RB
cord-023439-r04y1j22	129	21	enhance	enhance	VB
cord-023439-r04y1j22	129	22	the	the	DT
cord-023439-r04y1j22	129	23	cytokine	cytokine	NN
cord-023439-r04y1j22	129	24	responses	response	NNS
cord-023439-r04y1j22	129	25	,	,	,
cord-023439-r04y1j22	129	26	by	by	IN
cord-023439-r04y1j22	129	27	virtue	virtue	NN
cord-023439-r04y1j22	129	28	of	of	IN
cord-023439-r04y1j22	129	29	elevated	elevated	JJ
cord-023439-r04y1j22	129	30	anti	anti	JJ
cord-023439-r04y1j22	129	31	-	-	JJ
cord-023439-r04y1j22	129	32	MBP	mbp	JJ
cord-023439-r04y1j22	129	33	contents	content	NNS
cord-023439-r04y1j22	129	34	.	.	.
cord-023439-r04y1j22	130	1	The	the	DT
cord-023439-r04y1j22	130	2	phagolysosomally	phagolysosomally	RB
cord-023439-r04y1j22	130	3	localized	localized	JJ
cord-023439-r04y1j22	130	4	acid	acid	NN
cord-023439-r04y1j22	130	5	sphingomyelinase	sphingomyelinase	NN
cord-023439-r04y1j22	130	6	(	(	-LRB-
cord-023439-r04y1j22	130	7	ASMase	ASMase	NNP
cord-023439-r04y1j22	130	8	)	)	-RRB-
cord-023439-r04y1j22	131	1	activated	activate	VBN
cord-023439-r04y1j22	131	2	by	by	IN
cord-023439-r04y1j22	131	3	proinflammatory	proinflammatory	JJ
cord-023439-r04y1j22	131	4	cytokines	cytokine	NNS
cord-023439-r04y1j22	131	5	such	such	JJ
cord-023439-r04y1j22	131	6	as	as	IN
cord-023439-r04y1j22	131	7	TNF	TNF	NNP
cord-023439-r04y1j22	131	8	and	and	CC
cord-023439-r04y1j22	131	9	IFN	IFN	NNP
cord-023439-r04y1j22	131	10	-	-	HYPH
cord-023439-r04y1j22	131	11	g	g	NNP
cord-023439-r04y1j22	132	1	generates	generate	VBZ
cord-023439-r04y1j22	132	2	the	the	DT
cord-023439-r04y1j22	132	3	signalling	signal	VBG
cord-023439-r04y1j22	132	4	molecule	molecule	NN
cord-023439-r04y1j22	132	5	ceramide	ceramide	NN
cord-023439-r04y1j22	132	6	which	which	WDT
cord-023439-r04y1j22	132	7	in	in	IN
cord-023439-r04y1j22	132	8	turn	turn	NN
cord-023439-r04y1j22	132	9	results	result	VBZ
cord-023439-r04y1j22	132	10	in	in	IN
cord-023439-r04y1j22	132	11	the	the	DT
cord-023439-r04y1j22	132	12	activation	activation	NN
cord-023439-r04y1j22	132	13	of	of	IN
cord-023439-r04y1j22	132	14	proteases	protease	NNS
cord-023439-r04y1j22	132	15	like	like	IN
cord-023439-r04y1j22	133	1	cathepsin	cathepsin	NNP
cord-023439-r04y1j22	133	2	D.	D.	NNP
cord-023439-r04y1j22	133	3	These	these	DT
cord-023439-r04y1j22	133	4	characteristics	characteristic	NNS
cord-023439-r04y1j22	133	5	of	of	IN
cord-023439-r04y1j22	133	6	ASMase	ASMase	NNP
cord-023439-r04y1j22	133	7	suggest	suggest	VBP
cord-023439-r04y1j22	133	8	a	a	DT
cord-023439-r04y1j22	133	9	possible	possible	JJ
cord-023439-r04y1j22	133	10	role	role	NN
cord-023439-r04y1j22	133	11	of	of	IN
cord-023439-r04y1j22	133	12	this	this	DT
cord-023439-r04y1j22	133	13	molecule	molecule	NN
cord-023439-r04y1j22	133	14	in	in	IN
cord-023439-r04y1j22	133	15	the	the	DT
cord-023439-r04y1j22	133	16	phagocytotic	phagocytotic	JJ
cord-023439-r04y1j22	133	17	uptake	uptake	NN
cord-023439-r04y1j22	133	18	and	and	CC
cord-023439-r04y1j22	133	19	phagosomal	phagosomal	NN
cord-023439-r04y1j22	133	20	degradation	degradation	NN
cord-023439-r04y1j22	133	21	processes	process	NNS
cord-023439-r04y1j22	133	22	of	of	IN
cord-023439-r04y1j22	133	23	antigens	antigen	NNS
cord-023439-r04y1j22	133	24	or	or	CC
cord-023439-r04y1j22	133	25	in	in	IN
cord-023439-r04y1j22	133	26	antigen	antigen	NN
cord-023439-r04y1j22	133	27	presentation	presentation	NN
cord-023439-r04y1j22	133	28	.	.	.
cord-023439-r04y1j22	134	1	We	-PRON-	PRP
cord-023439-r04y1j22	134	2	show	show	VBP
cord-023439-r04y1j22	134	3	here	here	RB
cord-023439-r04y1j22	134	4	that	that	IN
cord-023439-r04y1j22	134	5	ASMase	asmase	NN
cord-023439-r04y1j22	134	6	-/mice	-/mice	NN
cord-023439-r04y1j22	134	7	fail	fail	VB
cord-023439-r04y1j22	134	8	to	to	TO
cord-023439-r04y1j22	134	9	eliminate	eliminate	VB
cord-023439-r04y1j22	134	10	the	the	DT
cord-023439-r04y1j22	134	11	noncytopathic	noncytopathic	JJ
cord-023439-r04y1j22	134	12	lymphocytic	lymphocytic	JJ
cord-023439-r04y1j22	134	13	choriomeningitis	choriomeningitis	NNP
cord-023439-r04y1j22	134	14	(	(	-LRB-
cord-023439-r04y1j22	134	15	LCM	LCM	NNP
cord-023439-r04y1j22	134	16	)	)	-RRB-
cord-023439-r04y1j22	134	17	virus	virus	NN
cord-023439-r04y1j22	134	18	as	as	RB
cord-023439-r04y1j22	134	19	rapidly	rapidly	RB
cord-023439-r04y1j22	134	20	as	as	IN
cord-023439-r04y1j22	134	21	littermate	littermate	NN
cord-023439-r04y1j22	134	22	wildtype	wildtype	NN
cord-023439-r04y1j22	134	23	mice	mouse	NNS
cord-023439-r04y1j22	134	24	.	.	.
cord-023439-r04y1j22	135	1	Investigation	investigation	NN
cord-023439-r04y1j22	135	2	of	of	IN
cord-023439-r04y1j22	135	3	the	the	DT
cord-023439-r04y1j22	135	4	immune	immune	JJ
cord-023439-r04y1j22	135	5	response	response	NN
cord-023439-r04y1j22	135	6	revealed	reveal	VBD
cord-023439-r04y1j22	135	7	a	a	DT
cord-023439-r04y1j22	135	8	reduced	reduce	VBN
cord-023439-r04y1j22	135	9	expansion	expansion	NN
cord-023439-r04y1j22	135	10	of	of	IN
cord-023439-r04y1j22	135	11	CD8	CD8	NNP
cord-023439-r04y1j22	135	12	þ	þ	NNP
cord-023439-r04y1j22	135	13	T	T	NNP
cord-023439-r04y1j22	135	14	cells	cell	NNS
cord-023439-r04y1j22	135	15	.	.	.
cord-023439-r04y1j22	136	1	The	the	DT
cord-023439-r04y1j22	136	2	secretion	secretion	NN
cord-023439-r04y1j22	136	3	of	of	IN
cord-023439-r04y1j22	136	4	IFN	IFN	NNP
cord-023439-r04y1j22	136	5	-	-	HYPH
cord-023439-r04y1j22	136	6	g	g	NNP
cord-023439-r04y1j22	136	7	in	in	IN
cord-023439-r04y1j22	136	8	response	response	NN
cord-023439-r04y1j22	136	9	to	to	TO
cord-023439-r04y1j22	136	10	contact	contact	VB
cord-023439-r04y1j22	136	11	with	with	IN
cord-023439-r04y1j22	136	12	target	target	NN
cord-023439-r04y1j22	136	13	cells	cell	NNS
cord-023439-r04y1j22	136	14	as	as	RB
cord-023439-r04y1j22	136	15	well	well	RB
cord-023439-r04y1j22	136	16	as	as	IN
cord-023439-r04y1j22	136	17	the	the	DT
cord-023439-r04y1j22	136	18	cytolytic	cytolytic	JJ
cord-023439-r04y1j22	136	19	activity	activity	NN
cord-023439-r04y1j22	136	20	of	of	IN
cord-023439-r04y1j22	136	21	virus	virus	NN
cord-023439-r04y1j22	136	22	-	-	HYPH
cord-023439-r04y1j22	136	23	specific	specific	JJ
cord-023439-r04y1j22	136	24	CD8	CD8	NNP
cord-023439-r04y1j22	136	25	þ	þ	NNP
cord-023439-r04y1j22	136	26	T	t	NN
cord-023439-r04y1j22	136	27	cells	cell	NNS
cord-023439-r04y1j22	136	28	was	be	VBD
cord-023439-r04y1j22	136	29	severely	severely	RB
cord-023439-r04y1j22	136	30	impaired	impaired	JJ
cord-023439-r04y1j22	136	31	.	.	.
cord-023439-r04y1j22	137	1	Additionally	additionally	RB
cord-023439-r04y1j22	137	2	,	,	,
cord-023439-r04y1j22	137	3	both	both	DT
cord-023439-r04y1j22	137	4	phases	phase	NNS
cord-023439-r04y1j22	137	5	of	of	IN
cord-023439-r04y1j22	137	6	the	the	DT
cord-023439-r04y1j22	137	7	LCM	LCM	NNP
cord-023439-r04y1j22	137	8	virus	virus	NN
cord-023439-r04y1j22	137	9	-	-	HYPH
cord-023439-r04y1j22	137	10	specific	specific	JJ
cord-023439-r04y1j22	137	11	DTH	DTH	NNP
cord-023439-r04y1j22	137	12	response	response	NN
cord-023439-r04y1j22	137	13	,	,	,
cord-023439-r04y1j22	137	14	mediated	mediate	VBN
cord-023439-r04y1j22	137	15	by	by	IN
cord-023439-r04y1j22	137	16	CD8	CD8	NNP
cord-023439-r04y1j22	137	17	þ	þ	NNP
cord-023439-r04y1j22	137	18	and	and	CC
cord-023439-r04y1j22	137	19	CD4	CD4	NNP
cord-023439-r04y1j22	137	20	þ	þ	NNP
cord-023439-r04y1j22	137	21	T	t	NN
cord-023439-r04y1j22	137	22	cells	cell	NNS
cord-023439-r04y1j22	137	23	consecutively	consecutively	RB
cord-023439-r04y1j22	137	24	,	,	,
cord-023439-r04y1j22	137	25	were	be	VBD
cord-023439-r04y1j22	137	26	diminished	diminish	VBN
cord-023439-r04y1j22	137	27	in	in	IN
cord-023439-r04y1j22	137	28	ASMase	ASMase	NNP
cord-023439-r04y1j22	137	29	-/mice	-/mice	NN
cord-023439-r04y1j22	137	30	.	.	.
cord-023439-r04y1j22	138	1	However	however	RB
cord-023439-r04y1j22	138	2	,	,	,
cord-023439-r04y1j22	138	3	the	the	DT
cord-023439-r04y1j22	138	4	secondary	secondary	JJ
cord-023439-r04y1j22	138	5	memory	memory	NN
cord-023439-r04y1j22	138	6	response	response	NN
cord-023439-r04y1j22	138	7	of	of	IN
cord-023439-r04y1j22	138	8	virus	virus	NN
cord-023439-r04y1j22	138	9	-	-	HYPH
cord-023439-r04y1j22	138	10	specific	specific	JJ
cord-023439-r04y1j22	138	11	CTL	CTL	NNP
cord-023439-r04y1j22	138	12	was	be	VBD
cord-023439-r04y1j22	138	13	not	not	RB
cord-023439-r04y1j22	138	14	altered	alter	VBN
cord-023439-r04y1j22	138	15	,	,	,
cord-023439-r04y1j22	138	16	and	and	CC
cord-023439-r04y1j22	138	17	the	the	DT
cord-023439-r04y1j22	138	18	614	614	CD
cord-023439-r04y1j22	138	19	Abstracts	abstract	NNS
cord-023439-r04y1j22	138	20	.................................................................................................................................................................................................	.................................................................................................................................................................................................	.
cord-023439-r04y1j22	139	1	virus	virus	NN
cord-023439-r04y1j22	139	2	was	be	VBD
cord-023439-r04y1j22	139	3	effectively	effectively	RB
cord-023439-r04y1j22	139	4	controlled	control	VBN
cord-023439-r04y1j22	139	5	for	for	IN
cord-023439-r04y1j22	139	6	at	at	RB
cord-023439-r04y1j22	139	7	least	least	JJS
cord-023439-r04y1j22	139	8	3	3	CD
cord-023439-r04y1j22	139	9	months	month	NNS
cord-023439-r04y1j22	139	10	by	by	IN
cord-023439-r04y1j22	139	11	ASMase	ASMase	NNP
cord-023439-r04y1j22	139	12	-/mice	-/mice	NN
cord-023439-r04y1j22	139	13	.	.	.
cord-023439-r04y1j22	140	1	In	in	IN
cord-023439-r04y1j22	140	2	conclusion	conclusion	NN
cord-023439-r04y1j22	140	3	,	,	,
cord-023439-r04y1j22	140	4	the	the	DT
cord-023439-r04y1j22	140	5	results	result	NNS
cord-023439-r04y1j22	140	6	of	of	IN
cord-023439-r04y1j22	140	7	this	this	DT
cord-023439-r04y1j22	140	8	study	study	NN
cord-023439-r04y1j22	140	9	suggest	suggest	VBP
cord-023439-r04y1j22	140	10	an	an	DT
cord-023439-r04y1j22	140	11	involvement	involvement	NN
cord-023439-r04y1j22	140	12	of	of	IN
cord-023439-r04y1j22	140	13	the	the	DT
cord-023439-r04y1j22	140	14	ASMase	asmase	NN
cord-023439-r04y1j22	140	15	in	in	IN
cord-023439-r04y1j22	140	16	the	the	DT
cord-023439-r04y1j22	140	17	activation	activation	NN
cord-023439-r04y1j22	140	18	,	,	,
cord-023439-r04y1j22	140	19	expansion	expansion	NN
cord-023439-r04y1j22	140	20	or	or	CC
cord-023439-r04y1j22	140	21	maturation	maturation	NN
cord-023439-r04y1j22	140	22	of	of	IN
cord-023439-r04y1j22	140	23	virus	virus	NN
cord-023439-r04y1j22	140	24	-	-	HYPH
cord-023439-r04y1j22	140	25	specific	specific	JJ
cord-023439-r04y1j22	140	26	CD8	CD8	NNP
cord-023439-r04y1j22	140	27	þ	þ	NNP
cord-023439-r04y1j22	140	28	T	t	NN
cord-023439-r04y1j22	140	29	cells	cell	NNS
cord-023439-r04y1j22	140	30	during	during	IN
cord-023439-r04y1j22	140	31	the	the	DT
cord-023439-r04y1j22	140	32	acute	acute	JJ
cord-023439-r04y1j22	140	33	infection	infection	NN
cord-023439-r04y1j22	140	34	of	of	IN
cord-023439-r04y1j22	140	35	mice	mouse	NNS
cord-023439-r04y1j22	140	36	with	with	IN
cord-023439-r04y1j22	140	37	the	the	DT
cord-023439-r04y1j22	140	38	LCM	LCM	NNP
cord-023439-r04y1j22	140	39	virus	virus	NN
cord-023439-r04y1j22	140	40	.	.	.
cord-023439-r04y1j22	141	1	Novel	Novel	NNP
cord-023439-r04y1j22	141	2	Markers	Markers	NNPS
cord-023439-r04y1j22	141	3	for	for	IN
cord-023439-r04y1j22	141	4	Alternative	Alternative	NNP
cord-023439-r04y1j22	141	5	Activation	Activation	NNP
cord-023439-r04y1j22	141	6	of	of	IN
cord-023439-r04y1j22	141	7	Macrophages	Macrophages	NNPS
cord-023439-r04y1j22	141	8	:	:	:
cord-023439-r04y1j22	141	9	Macrophage	Macrophage	NNP
cord-023439-r04y1j22	141	10	Galactose	Galactose	NNP
cord-023439-r04y1j22	141	11	-	-	HYPH
cord-023439-r04y1j22	141	12	Type	Type	NNP
cord-023439-r04y1j22	141	13	C	c	NN
cord-023439-r04y1j22	141	14	-	-	HYPH
cord-023439-r04y1j22	141	15	Type	Type	NNP
cord-023439-r04y1j22	141	16	Lectins	Lectins	NNP
cord-023439-r04y1j22	141	17	1	1	CD
cord-023439-r04y1j22	141	18	and	and	CC
cord-023439-r04y1j22	141	19	2	2	CD
cord-023439-r04y1j22	142	1	In	in	IN
cord-023439-r04y1j22	142	2	parallel	parallel	NN
cord-023439-r04y1j22	142	3	with	with	IN
cord-023439-r04y1j22	142	4	the	the	DT
cord-023439-r04y1j22	142	5	Th1	th1	CD
cord-023439-r04y1j22	142	6	/	/	SYM
cord-023439-r04y1j22	142	7	Th2	th2	CD
cord-023439-r04y1j22	142	8	dichotomy	dichotomy	NN
cord-023439-r04y1j22	142	9	,	,	,
cord-023439-r04y1j22	142	10	macrophages	macrophage	NNS
cord-023439-r04y1j22	142	11	are	be	VBP
cord-023439-r04y1j22	142	12	capable	capable	JJ
cord-023439-r04y1j22	142	13	of	of	IN
cord-023439-r04y1j22	142	14	developing	develop	VBG
cord-023439-r04y1j22	142	15	into	into	IN
cord-023439-r04y1j22	142	16	functionally	functionally	RB
cord-023439-r04y1j22	142	17	and	and	CC
cord-023439-r04y1j22	142	18	molecularly	molecularly	RB
cord-023439-r04y1j22	142	19	distinct	distinct	JJ
cord-023439-r04y1j22	142	20	subpopulations	subpopulation	NNS
cord-023439-r04y1j22	142	21	,	,	,
cord-023439-r04y1j22	142	22	due	due	IN
cord-023439-r04y1j22	142	23	to	to	IN
cord-023439-r04y1j22	142	24	differences	difference	NNS
cord-023439-r04y1j22	142	25	in	in	IN
cord-023439-r04y1j22	142	26	,	,	,
cord-023439-r04y1j22	142	27	for	for	IN
cord-023439-r04y1j22	142	28	example	example	NN
cord-023439-r04y1j22	142	29	cytokine	cytokine	NN
cord-023439-r04y1j22	142	30	environment	environment	NN
cord-023439-r04y1j22	142	31	and	and	CC
cord-023439-r04y1j22	142	32	pathological	pathological	JJ
cord-023439-r04y1j22	142	33	conditions	condition	NNS
cord-023439-r04y1j22	142	34	.	.	.
cord-023439-r04y1j22	143	1	While	while	IN
cord-023439-r04y1j22	143	2	the	the	DT
cord-023439-r04y1j22	143	3	best	well	RBS
cord-023439-r04y1j22	143	4	-	-	HYPH
cord-023439-r04y1j22	143	5	studied	study	VBN
cord-023439-r04y1j22	143	6	,	,	,
cord-023439-r04y1j22	143	7	classically	classically	RB
cord-023439-r04y1j22	143	8	activated	activate	VBN
cord-023439-r04y1j22	143	9	macrophage	macrophage	NN
cord-023439-r04y1j22	143	10	is	be	VBZ
cord-023439-r04y1j22	143	11	induced	induce	VBN
cord-023439-r04y1j22	143	12	by	by	IN
cord-023439-r04y1j22	143	13	type	type	NN
cord-023439-r04y1j22	144	1	I	-PRON-	PRP
cord-023439-r04y1j22	144	2	stimuli	stimulus	NNS
cord-023439-r04y1j22	144	3	such	such	JJ
cord-023439-r04y1j22	144	4	as	as	IN
cord-023439-r04y1j22	144	5	IFN	IFN	NNP
cord-023439-r04y1j22	144	6	-	-	HYPH
cord-023439-r04y1j22	144	7	g	g	NNP
cord-023439-r04y1j22	144	8	,	,	,
cord-023439-r04y1j22	145	1	a	a	DT
cord-023439-r04y1j22	145	2	type	type	NN
cord-023439-r04y1j22	145	3	II	II	NNP
cord-023439-r04y1j22	145	4	cytokine	cytokine	NN
cord-023439-r04y1j22	145	5	environment	environment	NN
cord-023439-r04y1j22	145	6	antagonizes	antagonize	VBZ
cord-023439-r04y1j22	145	7	the	the	DT
cord-023439-r04y1j22	145	8	classical	classical	JJ
cord-023439-r04y1j22	145	9	activation	activation	NN
cord-023439-r04y1j22	145	10	of	of	IN
cord-023439-r04y1j22	145	11	macrophages	macrophage	NNS
cord-023439-r04y1j22	145	12	and	and	CC
cord-023439-r04y1j22	145	13	is	be	VBZ
cord-023439-r04y1j22	145	14	capable	capable	JJ
cord-023439-r04y1j22	145	15	of	of	IN
cord-023439-r04y1j22	145	16	alternatively	alternatively	RB
cord-023439-r04y1j22	145	17	activating	activate	VBG
cord-023439-r04y1j22	145	18	macrophages	macrophage	NNS
cord-023439-r04y1j22	145	19	.	.	.
cord-023439-r04y1j22	146	1	However	however	RB
cord-023439-r04y1j22	146	2	,	,	,
cord-023439-r04y1j22	146	3	molecular	molecular	JJ
cord-023439-r04y1j22	146	4	markers	marker	NNS
cord-023439-r04y1j22	146	5	associated	associate	VBN
cord-023439-r04y1j22	146	6	with	with	IN
cord-023439-r04y1j22	146	7	these	these	DT
cord-023439-r04y1j22	146	8	type	type	NN
cord-023439-r04y1j22	146	9	II	ii	CD
cord-023439-r04y1j22	146	10	cytokine	cytokine	NN
cord-023439-r04y1j22	146	11	-	-	HYPH
cord-023439-r04y1j22	146	12	dependent	dependent	JJ
cord-023439-r04y1j22	146	13	,	,	,
cord-023439-r04y1j22	146	14	alternatively	alternatively	RB
cord-023439-r04y1j22	146	15	activated	activate	VBN
cord-023439-r04y1j22	146	16	macrophages	macrophage	NNS
cord-023439-r04y1j22	146	17	remain	remain	VBP
cord-023439-r04y1j22	146	18	scarce	scarce	JJ
cord-023439-r04y1j22	146	19	.	.	.
cord-023439-r04y1j22	147	1	Besides	besides	IN
cord-023439-r04y1j22	147	2	the	the	DT
cord-023439-r04y1j22	147	3	earlier	early	RBR
cord-023439-r04y1j22	147	4	documented	document	VBN
cord-023439-r04y1j22	147	5	markers	marker	NNS
cord-023439-r04y1j22	147	6	macrophage	macrophage	NN
cord-023439-r04y1j22	147	7	mannose	mannose	NN
cord-023439-r04y1j22	147	8	receptor	receptor	NN
cord-023439-r04y1j22	147	9	and	and	CC
cord-023439-r04y1j22	147	10	arginase	arginase	NNP
cord-023439-r04y1j22	147	11	1	1	CD
cord-023439-r04y1j22	147	12	,	,	,
cord-023439-r04y1j22	147	13	we	-PRON-	PRP
cord-023439-r04y1j22	147	14	recently	recently	RB
cord-023439-r04y1j22	147	15	demonstrated	demonstrate	VBD
cord-023439-r04y1j22	147	16	that	that	IN
cord-023439-r04y1j22	147	17	murine	murine	NN
cord-023439-r04y1j22	147	18	alternatively	alternatively	RB
cord-023439-r04y1j22	147	19	activated	activate	VBN
cord-023439-r04y1j22	147	20	macrophages	macrophage	NNS
cord-023439-r04y1j22	147	21	are	be	VBP
cord-023439-r04y1j22	147	22	characterized	characterize	VBN
cord-023439-r04y1j22	147	23	by	by	IN
cord-023439-r04y1j22	147	24	increased	increase	VBN
cord-023439-r04y1j22	147	25	expression	expression	NN
cord-023439-r04y1j22	147	26	of	of	IN
cord-023439-r04y1j22	147	27	FIZZ1	FIZZ1	NNP
cord-023439-r04y1j22	147	28	and	and	CC
cord-023439-r04y1j22	147	29	Ym	Ym	NNP
cord-023439-r04y1j22	147	30	.	.	.
cord-023439-r04y1j22	148	1	We	-PRON-	PRP
cord-023439-r04y1j22	148	2	now	now	RB
cord-023439-r04y1j22	148	3	report	report	VBP
cord-023439-r04y1j22	148	4	that	that	DT
cord-023439-r04y1j22	148	5	expression	expression	NN
cord-023439-r04y1j22	148	6	of	of	IN
cord-023439-r04y1j22	148	7	the	the	DT
cord-023439-r04y1j22	148	8	two	two	CD
cord-023439-r04y1j22	148	9	members	member	NNS
cord-023439-r04y1j22	148	10	of	of	IN
cord-023439-r04y1j22	148	11	the	the	DT
cord-023439-r04y1j22	148	12	mouse	mouse	NN
cord-023439-r04y1j22	148	13	macrophage	macrophage	NN
cord-023439-r04y1j22	148	14	galactose	galactose	NN
cord-023439-r04y1j22	148	15	-	-	HYPH
cord-023439-r04y1j22	148	16	type	type	NN
cord-023439-r04y1j22	148	17	C	c	NN
cord-023439-r04y1j22	148	18	-	-	HYPH
cord-023439-r04y1j22	148	19	type	type	NN
cord-023439-r04y1j22	148	20	lectin	lectin	NN
cord-023439-r04y1j22	148	21	gene	gene	NN
cord-023439-r04y1j22	148	22	family	family	NN
cord-023439-r04y1j22	148	23	,	,	,
cord-023439-r04y1j22	148	24	termed	term	VBN
cord-023439-r04y1j22	148	25	mMGL1	mmgl1	NN
cord-023439-r04y1j22	148	26	and	and	CC
cord-023439-r04y1j22	148	27	mMGL2	mmgl2	NN
cord-023439-r04y1j22	148	28	,	,	,
cord-023439-r04y1j22	148	29	is	be	VBZ
cord-023439-r04y1j22	148	30	induced	induce	VBN
cord-023439-r04y1j22	148	31	in	in	IN
cord-023439-r04y1j22	148	32	diverse	diverse	JJ
cord-023439-r04y1j22	148	33	populations	population	NNS
cord-023439-r04y1j22	148	34	of	of	IN
cord-023439-r04y1j22	148	35	alternatively	alternatively	RB
cord-023439-r04y1j22	148	36	activated	activate	VBN
cord-023439-r04y1j22	148	37	macrophages	macrophage	NNS
cord-023439-r04y1j22	148	38	,	,	,
cord-023439-r04y1j22	148	39	including	include	VBG
cord-023439-r04y1j22	148	40	peritoneal	peritoneal	JJ
cord-023439-r04y1j22	148	41	macrophages	macrophage	NNS
cord-023439-r04y1j22	148	42	elicited	elicit	VBN
cord-023439-r04y1j22	148	43	during	during	IN
cord-023439-r04y1j22	148	44	infection	infection	NN
cord-023439-r04y1j22	148	45	with	with	IN
cord-023439-r04y1j22	148	46	the	the	DT
cord-023439-r04y1j22	148	47	protozoan	protozoan	NN
cord-023439-r04y1j22	148	48	Trypanosoma	Trypanosoma	NNP
cord-023439-r04y1j22	148	49	brucei	brucei	NNP
cord-023439-r04y1j22	148	50	or	or	CC
cord-023439-r04y1j22	148	51	the	the	DT
cord-023439-r04y1j22	148	52	Helminth	Helminth	NNP
cord-023439-r04y1j22	148	53	Taenia	Taenia	NNP
cord-023439-r04y1j22	148	54	crassiceps	crassiceps	NN
cord-023439-r04y1j22	148	55	,	,	,
cord-023439-r04y1j22	148	56	and	and	CC
cord-023439-r04y1j22	148	57	alveolar	alveolar	NN
cord-023439-r04y1j22	148	58	macrophages	macrophage	NNS
cord-023439-r04y1j22	148	59	elicited	elicit	VBN
cord-023439-r04y1j22	148	60	in	in	IN
cord-023439-r04y1j22	148	61	a	a	DT
cord-023439-r04y1j22	148	62	mouse	mouse	NN
cord-023439-r04y1j22	148	63	model	model	NN
cord-023439-r04y1j22	148	64	of	of	IN
cord-023439-r04y1j22	148	65	allergic	allergic	JJ
cord-023439-r04y1j22	148	66	asthma	asthma	NN
cord-023439-r04y1j22	148	67	.	.	.
cord-023439-r04y1j22	149	1	We	-PRON-	PRP
cord-023439-r04y1j22	149	2	also	also	RB
cord-023439-r04y1j22	149	3	demonstrate	demonstrate	VBP
cord-023439-r04y1j22	149	4	that	that	IN
cord-023439-r04y1j22	149	5	,	,	,
cord-023439-r04y1j22	149	6	in	in	IN
cord-023439-r04y1j22	149	7	vitro	vitro	FW
cord-023439-r04y1j22	149	8	,	,	,
cord-023439-r04y1j22	149	9	interleukin-4	interleukin-4	NNP
cord-023439-r04y1j22	149	10	and	and	CC
cord-023439-r04y1j22	149	11	interleukin-13	interleukin-13	NN
cord-023439-r04y1j22	149	12	upregulate	upregulate	VBP
cord-023439-r04y1j22	149	13	mMGL1	mmgl1	NN
cord-023439-r04y1j22	149	14	and	and	CC
cord-023439-r04y1j22	149	15	mMGL2	mmgl2	NN
cord-023439-r04y1j22	149	16	expression	expression	NN
cord-023439-r04y1j22	149	17	and	and	CC
cord-023439-r04y1j22	149	18	that	that	IN
cord-023439-r04y1j22	149	19	,	,	,
cord-023439-r04y1j22	149	20	in	in	IN
cord-023439-r04y1j22	149	21	vivo	vivo	NN
cord-023439-r04y1j22	149	22	,	,	,
cord-023439-r04y1j22	149	23	induction	induction	NN
cord-023439-r04y1j22	149	24	of	of	IN
cord-023439-r04y1j22	149	25	mMGL1	mmgl1	NN
cord-023439-r04y1j22	150	1	and	and	CC
cord-023439-r04y1j22	150	2	mMGL2	mmgl2	NN
cord-023439-r04y1j22	150	3	is	be	VBZ
cord-023439-r04y1j22	150	4	dependent	dependent	JJ
cord-023439-r04y1j22	150	5	on	on	IN
cord-023439-r04y1j22	150	6	interleukin-4	interleukin-4	NNP
cord-023439-r04y1j22	150	7	receptor	receptor	NN
cord-023439-r04y1j22	150	8	signalling	signalling	NN
cord-023439-r04y1j22	150	9	.	.	.
cord-023439-r04y1j22	151	1	Moreover	moreover	RB
cord-023439-r04y1j22	151	2	,	,	,
cord-023439-r04y1j22	151	3	we	-PRON-	PRP
cord-023439-r04y1j22	151	4	show	show	VBP
cord-023439-r04y1j22	151	5	that	that	IN
cord-023439-r04y1j22	151	6	regulation	regulation	NN
cord-023439-r04y1j22	151	7	of	of	IN
cord-023439-r04y1j22	151	8	MGL	MGL	NNP
cord-023439-r04y1j22	151	9	expression	expression	NN
cord-023439-r04y1j22	151	10	is	be	VBZ
cord-023439-r04y1j22	151	11	similar	similar	JJ
cord-023439-r04y1j22	151	12	in	in	IN
cord-023439-r04y1j22	151	13	human	human	JJ
cord-023439-r04y1j22	151	14	monocytes	monocyte	NNS
cord-023439-r04y1j22	151	15	and	and	CC
cord-023439-r04y1j22	151	16	monocyte	monocyte	NN
cord-023439-r04y1j22	151	17	-	-	HYPH
cord-023439-r04y1j22	151	18	derived	derive	VBN
cord-023439-r04y1j22	151	19	macrophages	macrophage	NNS
cord-023439-r04y1j22	151	20	.	.	.
cord-023439-r04y1j22	152	1	Hence	hence	RB
cord-023439-r04y1j22	152	2	,	,	,
cord-023439-r04y1j22	152	3	macrophage	macrophage	NN
cord-023439-r04y1j22	152	4	galactose	galactose	NN
cord-023439-r04y1j22	152	5	-	-	HYPH
cord-023439-r04y1j22	152	6	type	type	NN
cord-023439-r04y1j22	152	7	C	c	NN
cord-023439-r04y1j22	152	8	-	-	HYPH
cord-023439-r04y1j22	152	9	type	type	NN
cord-023439-r04y1j22	152	10	lectins	lectin	NNS
cord-023439-r04y1j22	152	11	represent	represent	VBP
cord-023439-r04y1j22	152	12	novel	novel	JJ
cord-023439-r04y1j22	152	13	markers	marker	NNS
cord-023439-r04y1j22	152	14	for	for	IN
cord-023439-r04y1j22	152	15	both	both	CC
cord-023439-r04y1j22	152	16	murine	murine	JJ
cord-023439-r04y1j22	152	17	and	and	CC
cord-023439-r04y1j22	152	18	human	human	JJ
cord-023439-r04y1j22	152	19	alternatively	alternatively	RB
cord-023439-r04y1j22	152	20	activated	activate	VBN
cord-023439-r04y1j22	152	21	macrophages	macrophage	NNS
cord-023439-r04y1j22	152	22	;	;	:
cord-023439-r04y1j22	152	23	thus	thus	RB
cord-023439-r04y1j22	152	24	,	,	,
cord-023439-r04y1j22	152	25	paving	pave	VBG
cord-023439-r04y1j22	152	26	the	the	DT
cord-023439-r04y1j22	152	27	way	way	NN
cord-023439-r04y1j22	152	28	for	for	IN
cord-023439-r04y1j22	152	29	further	further	JJ
cord-023439-r04y1j22	152	30	characterization	characterization	NN
cord-023439-r04y1j22	152	31	of	of	IN
cord-023439-r04y1j22	152	32	the	the	DT
cord-023439-r04y1j22	152	33	phenotype	phenotype	NN
cord-023439-r04y1j22	152	34	of	of	IN
cord-023439-r04y1j22	152	35	macrophages	macrophage	NNS
cord-023439-r04y1j22	152	36	occurring	occur	VBG
cord-023439-r04y1j22	152	37	in	in	IN
cord-023439-r04y1j22	152	38	Th2	th2	CD
cord-023439-r04y1j22	152	39	conditions	condition	NNS
cord-023439-r04y1j22	152	40	.	.	.
cord-023439-r04y1j22	153	1	Background	background	NN
cord-023439-r04y1j22	153	2	:	:	:
cord-023439-r04y1j22	154	1	Human	human	JJ
cord-023439-r04y1j22	154	2	parvovirus	parvovirus	NN
cord-023439-r04y1j22	154	3	B19	B19	NNP
cord-023439-r04y1j22	154	4	(	(	-LRB-
cord-023439-r04y1j22	154	5	B19	B19	NNP
cord-023439-r04y1j22	154	6	)	)	-RRB-
cord-023439-r04y1j22	154	7	is	be	VBZ
cord-023439-r04y1j22	154	8	a	a	DT
cord-023439-r04y1j22	154	9	ubiquitous	ubiquitous	JJ
cord-023439-r04y1j22	154	10	pathogen	pathogen	NN
cord-023439-r04y1j22	154	11	,	,	,
cord-023439-r04y1j22	154	12	normally	normally	RB
cord-023439-r04y1j22	154	13	causing	cause	VBG
cord-023439-r04y1j22	154	14	a	a	DT
cord-023439-r04y1j22	154	15	mild	mild	JJ
cord-023439-r04y1j22	154	16	self	self	NN
cord-023439-r04y1j22	154	17	-	-	HYPH
cord-023439-r04y1j22	154	18	limiting	limit	VBG
cord-023439-r04y1j22	154	19	disease	disease	NN
cord-023439-r04y1j22	154	20	,	,	,
cord-023439-r04y1j22	154	21	but	but	CC
cord-023439-r04y1j22	154	22	also	also	RB
cord-023439-r04y1j22	154	23	capable	capable	JJ
cord-023439-r04y1j22	154	24	of	of	IN
cord-023439-r04y1j22	154	25	causing	cause	VBG
cord-023439-r04y1j22	154	26	both	both	DT
cord-023439-r04y1j22	154	27	significant	significant	JJ
cord-023439-r04y1j22	154	28	pathology	pathology	NN
cord-023439-r04y1j22	154	29	and	and	CC
cord-023439-r04y1j22	154	30	long	long	JJ
cord-023439-r04y1j22	154	31	-	-	HYPH
cord-023439-r04y1j22	154	32	term	term	NN
cord-023439-r04y1j22	154	33	persistence	persistence	NN
cord-023439-r04y1j22	154	34	.	.	.
cord-023439-r04y1j22	155	1	The	the	DT
cord-023439-r04y1j22	155	2	small	small	JJ
cord-023439-r04y1j22	155	3	size	size	NN
cord-023439-r04y1j22	155	4	and	and	CC
cord-023439-r04y1j22	155	5	stability	stability	NN
cord-023439-r04y1j22	155	6	of	of	IN
cord-023439-r04y1j22	155	7	the	the	DT
cord-023439-r04y1j22	155	8	virus	virus	NN
cord-023439-r04y1j22	155	9	makes	make	VBZ
cord-023439-r04y1j22	155	10	it	-PRON-	PRP
cord-023439-r04y1j22	155	11	suitable	suitable	JJ
cord-023439-r04y1j22	155	12	for	for	IN
cord-023439-r04y1j22	155	13	mapping	mapping	NN
cord-023439-r04y1j22	155	14	of	of	IN
cord-023439-r04y1j22	155	15	the	the	DT
cord-023439-r04y1j22	155	16	full	full	JJ
cord-023439-r04y1j22	155	17	breath	breath	NN
cord-023439-r04y1j22	155	18	and	and	CC
cord-023439-r04y1j22	155	19	the	the	DT
cord-023439-r04y1j22	155	20	kinetics	kinetic	NNS
cord-023439-r04y1j22	155	21	of	of	IN
cord-023439-r04y1j22	155	22	the	the	DT
cord-023439-r04y1j22	155	23	cellular	cellular	JJ
cord-023439-r04y1j22	155	24	immune	immune	JJ
cord-023439-r04y1j22	155	25	responses	response	NNS
cord-023439-r04y1j22	155	26	following	follow	VBG
cord-023439-r04y1j22	155	27	acute	acute	JJ
cord-023439-r04y1j22	155	28	viral	viral	JJ
cord-023439-r04y1j22	155	29	infection	infection	NN
cord-023439-r04y1j22	155	30	.	.	.
cord-023439-r04y1j22	156	1	Methods	method	NNS
cord-023439-r04y1j22	156	2	:	:	:
cord-023439-r04y1j22	156	3	Five	five	CD
cord-023439-r04y1j22	156	4	patients	patient	NNS
cord-023439-r04y1j22	156	5	with	with	IN
cord-023439-r04y1j22	156	6	acute	acute	JJ
cord-023439-r04y1j22	156	7	primary	primary	JJ
cord-023439-r04y1j22	156	8	B19	B19	NNP
cord-023439-r04y1j22	156	9	infection	infection	NN
cord-023439-r04y1j22	156	10	were	be	VBD
cord-023439-r04y1j22	156	11	included	include	VBN
cord-023439-r04y1j22	156	12	in	in	IN
cord-023439-r04y1j22	156	13	the	the	DT
cord-023439-r04y1j22	156	14	study	study	NN
cord-023439-r04y1j22	156	15	and	and	CC
cord-023439-r04y1j22	156	16	followed	follow	VBD
cord-023439-r04y1j22	156	17	consecutively	consecutively	RB
cord-023439-r04y1j22	156	18	for	for	IN
cord-023439-r04y1j22	156	19	up	up	IN
cord-023439-r04y1j22	156	20	to	to	TO
cord-023439-r04y1j22	156	21	200	200	CD
cord-023439-r04y1j22	156	22	weeks	week	NNS
cord-023439-r04y1j22	156	23	.	.	.
cord-023439-r04y1j22	157	1	Cellular	cellular	JJ
cord-023439-r04y1j22	157	2	immune	immune	JJ
cord-023439-r04y1j22	157	3	responses	response	NNS
cord-023439-r04y1j22	157	4	were	be	VBD
cord-023439-r04y1j22	157	5	mapped	map	VBN
cord-023439-r04y1j22	157	6	by	by	IN
cord-023439-r04y1j22	157	7	IFNg	IFNg	NNP
cord-023439-r04y1j22	157	8	enzyme	enzyme	NN
cord-023439-r04y1j22	157	9	-	-	HYPH
cord-023439-r04y1j22	157	10	linked	link	VBN
cord-023439-r04y1j22	157	11	immunospot	immunospot	NN
cord-023439-r04y1j22	157	12	to	to	IN
cord-023439-r04y1j22	157	13	overlapping	overlap	VBG
cord-023439-r04y1j22	157	14	peptides	peptide	NNS
cord-023439-r04y1j22	157	15	spanning	span	VBG
cord-023439-r04y1j22	157	16	the	the	DT
cord-023439-r04y1j22	157	17	whole	whole	JJ
cord-023439-r04y1j22	157	18	B19	B19	NNP
cord-023439-r04y1j22	157	19	genome	genome	NN
cord-023439-r04y1j22	157	20	.	.	.
cord-023439-r04y1j22	158	1	Results	result	NNS
cord-023439-r04y1j22	158	2	:	:	:
cord-023439-r04y1j22	159	1	In	in	IN
cord-023439-r04y1j22	159	2	all	all	DT
cord-023439-r04y1j22	159	3	five	five	CD
cord-023439-r04y1j22	159	4	acutely	acutely	RB
cord-023439-r04y1j22	159	5	infected	infected	JJ
cord-023439-r04y1j22	159	6	patients	patient	NNS
cord-023439-r04y1j22	159	7	,	,	,
cord-023439-r04y1j22	159	8	we	-PRON-	PRP
cord-023439-r04y1j22	159	9	were	be	VBD
cord-023439-r04y1j22	159	10	able	able	JJ
cord-023439-r04y1j22	159	11	to	to	TO
cord-023439-r04y1j22	159	12	monitor	monitor	VB
cord-023439-r04y1j22	159	13	the	the	DT
cord-023439-r04y1j22	159	14	kinetics	kinetic	NNS
cord-023439-r04y1j22	159	15	of	of	IN
cord-023439-r04y1j22	159	16	a	a	DT
cord-023439-r04y1j22	159	17	strong	strong	JJ
cord-023439-r04y1j22	159	18	specific	specific	JJ
cord-023439-r04y1j22	159	19	cellular	cellular	JJ
cord-023439-r04y1j22	159	20	immune	immune	JJ
cord-023439-r04y1j22	159	21	reaction	reaction	NN
cord-023439-r04y1j22	159	22	.	.	.
cord-023439-r04y1j22	160	1	Responses	response	NNS
cord-023439-r04y1j22	160	2	peaked	peak	VBD
cord-023439-r04y1j22	160	3	at	at	IN
cord-023439-r04y1j22	160	4	levels	level	NNS
cord-023439-r04y1j22	160	5	of	of	IN
cord-023439-r04y1j22	160	6	850	850	CD
cord-023439-r04y1j22	160	7	-	-	HYPH
cord-023439-r04y1j22	160	8	1850	1850	CD
cord-023439-r04y1j22	160	9	SFC/	SFC/	NNP
cord-023439-r04y1j22	160	10	million	million	CD
cord-023439-r04y1j22	160	11	PBMCs	pbmc	NNS
cord-023439-r04y1j22	160	12	,	,	,
cord-023439-r04y1j22	160	13	roughly	roughly	RB
cord-023439-r04y1j22	160	14	corresponding	correspond	VBG
cord-023439-r04y1j22	160	15	to	to	IN
cord-023439-r04y1j22	160	16	0.3	0.3	CD
cord-023439-r04y1j22	160	17	-	-	SYM
cord-023439-r04y1j22	160	18	0.6	0.6	CD
cord-023439-r04y1j22	160	19	%	%	NN
cord-023439-r04y1j22	160	20	B19specific	B19specific	NNP
cord-023439-r04y1j22	160	21	CD8	CD8	NNP
cord-023439-r04y1j22	160	22	þ	þ	NNP
cord-023439-r04y1j22	160	23	cells	cell	NNS
cord-023439-r04y1j22	160	24	circulating	circulate	VBG
cord-023439-r04y1j22	160	25	in	in	IN
cord-023439-r04y1j22	160	26	peripheral	peripheral	JJ
cord-023439-r04y1j22	160	27	blood	blood	NN
cord-023439-r04y1j22	160	28	at	at	IN
cord-023439-r04y1j22	160	29	10	10	CD
cord-023439-r04y1j22	160	30	-	-	SYM
cord-023439-r04y1j22	160	31	80	80	CD
cord-023439-r04y1j22	160	32	weeks	week	NNS
cord-023439-r04y1j22	160	33	post	post	NN
cord-023439-r04y1j22	160	34	-	-	NN
cord-023439-r04y1j22	160	35	infection	infection	NN
cord-023439-r04y1j22	160	36	.	.	.
cord-023439-r04y1j22	161	1	The	the	DT
cord-023439-r04y1j22	161	2	responses	response	NNS
cord-023439-r04y1j22	161	3	in	in	IN
cord-023439-r04y1j22	161	4	individual	individual	JJ
cord-023439-r04y1j22	161	5	patients	patient	NNS
cord-023439-r04y1j22	161	6	were	be	VBD
cord-023439-r04y1j22	161	7	directed	direct	VBN
cord-023439-r04y1j22	161	8	to	to	IN
cord-023439-r04y1j22	161	9	three	three	CD
cord-023439-r04y1j22	161	10	or	or	CC
cord-023439-r04y1j22	161	11	four	four	CD
cord-023439-r04y1j22	161	12	different	different	JJ
cord-023439-r04y1j22	161	13	peptide	peptide	NN
cord-023439-r04y1j22	161	14	pools	pool	NNS
cord-023439-r04y1j22	161	15	,	,	,
cord-023439-r04y1j22	161	16	and	and	CC
cord-023439-r04y1j22	161	17	the	the	DT
cord-023439-r04y1j22	161	18	specificity	specificity	NN
cord-023439-r04y1j22	161	19	was	be	VBD
cord-023439-r04y1j22	161	20	confined	confine	VBN
cord-023439-r04y1j22	161	21	to	to	IN
cord-023439-r04y1j22	161	22	the	the	DT
cord-023439-r04y1j22	161	23	same	same	JJ
cord-023439-r04y1j22	161	24	CD8	CD8	NNP
cord-023439-r04y1j22	161	25	epitopes	epitope	NNS
cord-023439-r04y1j22	161	26	present	present	JJ
cord-023439-r04y1j22	161	27	in	in	IN
cord-023439-r04y1j22	161	28	the	the	DT
cord-023439-r04y1j22	161	29	pools	pool	NNS
cord-023439-r04y1j22	161	30	throughout	throughout	IN
cord-023439-r04y1j22	161	31	the	the	DT
cord-023439-r04y1j22	161	32	follow	follow	NN
cord-023439-r04y1j22	161	33	-	-	HYPH
cord-023439-r04y1j22	161	34	up	up	NN
cord-023439-r04y1j22	161	35	period	period	NN
cord-023439-r04y1j22	161	36	.	.	.
cord-023439-r04y1j22	162	1	The	the	DT
cord-023439-r04y1j22	162	2	majority	majority	NN
cord-023439-r04y1j22	162	3	of	of	IN
cord-023439-r04y1j22	162	4	responses	response	NNS
cord-023439-r04y1j22	162	5	were	be	VBD
cord-023439-r04y1j22	162	6	directed	direct	VBN
cord-023439-r04y1j22	162	7	to	to	IN
cord-023439-r04y1j22	162	8	the	the	DT
cord-023439-r04y1j22	162	9	virus	virus	NN
cord-023439-r04y1j22	162	10	nonstructural	nonstructural	JJ
cord-023439-r04y1j22	162	11	protein	protein	NN
cord-023439-r04y1j22	162	12	,	,	,
cord-023439-r04y1j22	162	13	only	only	RB
cord-023439-r04y1j22	162	14	two	two	CD
cord-023439-r04y1j22	162	15	patients	patient	NNS
cord-023439-r04y1j22	162	16	showed	show	VBD
cord-023439-r04y1j22	162	17	any	any	DT
cord-023439-r04y1j22	162	18	response	response	NN
cord-023439-r04y1j22	162	19	to	to	IN
cord-023439-r04y1j22	162	20	the	the	DT
cord-023439-r04y1j22	162	21	capsid	capsid	NN
cord-023439-r04y1j22	162	22	proteins	protein	NNS
cord-023439-r04y1j22	162	23	,	,	,
cord-023439-r04y1j22	162	24	elicited	elicit	VBN
cord-023439-r04y1j22	162	25	by	by	IN
cord-023439-r04y1j22	162	26	the	the	DT
cord-023439-r04y1j22	162	27	same	same	JJ
cord-023439-r04y1j22	162	28	epitope	epitope	NN
cord-023439-r04y1j22	162	29	in	in	IN
cord-023439-r04y1j22	162	30	both	both	DT
cord-023439-r04y1j22	162	31	cases	case	NNS
cord-023439-r04y1j22	162	32	.	.	.
cord-023439-r04y1j22	163	1	Conclusion	conclusion	NN
cord-023439-r04y1j22	163	2	:	:	:
cord-023439-r04y1j22	164	1	The	the	DT
cord-023439-r04y1j22	164	2	cellular	cellular	JJ
cord-023439-r04y1j22	164	3	immune	immune	JJ
cord-023439-r04y1j22	164	4	responses	response	NNS
cord-023439-r04y1j22	164	5	to	to	TO
cord-023439-r04y1j22	164	6	acute	acute	JJ
cord-023439-r04y1j22	164	7	B19	B19	NNP
cord-023439-r04y1j22	164	8	infection	infection	NN
cord-023439-r04y1j22	164	9	are	be	VBP
cord-023439-r04y1j22	164	10	surprisingly	surprisingly	RB
cord-023439-r04y1j22	164	11	narrow	narrow	JJ
cord-023439-r04y1j22	164	12	in	in	IN
cord-023439-r04y1j22	164	13	distribution	distribution	NN
cord-023439-r04y1j22	164	14	and	and	CC
cord-023439-r04y1j22	164	15	remain	remain	VB
cord-023439-r04y1j22	164	16	at	at	IN
cord-023439-r04y1j22	164	17	high	high	JJ
cord-023439-r04y1j22	164	18	levels	level	NNS
cord-023439-r04y1j22	164	19	for	for	IN
cord-023439-r04y1j22	164	20	up	up	IN
cord-023439-r04y1j22	164	21	to	to	TO
cord-023439-r04y1j22	164	22	80	80	CD
cord-023439-r04y1j22	164	23	weeks	week	NNS
cord-023439-r04y1j22	164	24	post	post	NN
cord-023439-r04y1j22	164	25	-	-	NN
cord-023439-r04y1j22	164	26	infection	infection	NN
cord-023439-r04y1j22	164	27	.	.	.
cord-023439-r04y1j22	165	1	The	the	DT
cord-023439-r04y1j22	165	2	initial	initial	JJ
cord-023439-r04y1j22	165	3	epitope	epitope	NN
cord-023439-r04y1j22	165	4	specificity	specificity	NN
cord-023439-r04y1j22	165	5	is	be	VBZ
cord-023439-r04y1j22	165	6	maintained	maintain	VBN
cord-023439-r04y1j22	165	7	,	,	,
cord-023439-r04y1j22	165	8	and	and	CC
cord-023439-r04y1j22	165	9	the	the	DT
cord-023439-r04y1j22	165	10	majority	majority	NN
cord-023439-r04y1j22	165	11	of	of	IN
cord-023439-r04y1j22	165	12	responses	response	NNS
cord-023439-r04y1j22	165	13	target	target	VBP
cord-023439-r04y1j22	165	14	the	the	DT
cord-023439-r04y1j22	165	15	virus	virus	NN
cord-023439-r04y1j22	165	16	nonstructural	nonstructural	JJ
cord-023439-r04y1j22	165	17	protein	protein	NN
cord-023439-r04y1j22	165	18	,	,	,
cord-023439-r04y1j22	165	19	which	which	WDT
cord-023439-r04y1j22	165	20	is	be	VBZ
cord-023439-r04y1j22	165	21	not	not	RB
cord-023439-r04y1j22	165	22	included	include	VBN
cord-023439-r04y1j22	165	23	in	in	IN
cord-023439-r04y1j22	165	24	vaccine	vaccine	NN
cord-023439-r04y1j22	165	25	preparations	preparation	NNS
cord-023439-r04y1j22	165	26	,	,	,
cord-023439-r04y1j22	165	27	evaluated	evaluate	VBN
cord-023439-r04y1j22	165	28	against	against	IN
cord-023439-r04y1j22	165	29	the	the	DT
cord-023439-r04y1j22	165	30	infection	infection	NN
cord-023439-r04y1j22	165	31	.	.	.
cord-023439-r04y1j22	166	1	The	the	DT
cord-023439-r04y1j22	166	2	relationship	relationship	NN
cord-023439-r04y1j22	166	3	between	between	IN
cord-023439-r04y1j22	166	4	malnutrition	malnutrition	NN
cord-023439-r04y1j22	166	5	and	and	CC
cord-023439-r04y1j22	166	6	malaria	malaria	NN
cord-023439-r04y1j22	166	7	is	be	VBZ
cord-023439-r04y1j22	166	8	controversial	controversial	JJ
cord-023439-r04y1j22	166	9	.	.	.
cord-023439-r04y1j22	167	1	On	on	IN
cord-023439-r04y1j22	167	2	one	one	CD
cord-023439-r04y1j22	167	3	hand	hand	NN
cord-023439-r04y1j22	167	4	,	,	,
cord-023439-r04y1j22	167	5	malaria	malaria	NN
cord-023439-r04y1j22	167	6	may	may	MD
cord-023439-r04y1j22	167	7	cause	cause	VB
cord-023439-r04y1j22	167	8	malnutrition	malnutrition	NN
cord-023439-r04y1j22	167	9	,	,	,
cord-023439-r04y1j22	167	10	while	while	IN
cord-023439-r04y1j22	167	11	on	on	IN
cord-023439-r04y1j22	167	12	the	the	DT
cord-023439-r04y1j22	167	13	other	other	JJ
cord-023439-r04y1j22	167	14	,	,	,
cord-023439-r04y1j22	167	15	malnutrition	malnutrition	NN
cord-023439-r04y1j22	167	16	itself	-PRON-	PRP
cord-023439-r04y1j22	167	17	may	may	MD
cord-023439-r04y1j22	167	18	modulate	modulate	VB
cord-023439-r04y1j22	167	19	susceptibility	susceptibility	NN
cord-023439-r04y1j22	167	20	to	to	IN
cord-023439-r04y1j22	167	21	the	the	DT
cord-023439-r04y1j22	167	22	disease	disease	NN
cord-023439-r04y1j22	167	23	.	.	.
cord-023439-r04y1j22	168	1	We	-PRON-	PRP
cord-023439-r04y1j22	168	2	investigated	investigate	VBD
cord-023439-r04y1j22	168	3	the	the	DT
cord-023439-r04y1j22	168	4	association	association	NN
cord-023439-r04y1j22	168	5	between	between	IN
cord-023439-r04y1j22	168	6	Plasmodium	Plasmodium	NNP
cord-023439-r04y1j22	168	7	falciparum	falciparum	NN
cord-023439-r04y1j22	168	8	malaria	malaria	NN
cord-023439-r04y1j22	168	9	and	and	CC
cord-023439-r04y1j22	168	10	malnutrition	malnutrition	NN
cord-023439-r04y1j22	168	11	in	in	IN
cord-023439-r04y1j22	168	12	a	a	DT
cord-023439-r04y1j22	168	13	cohort	cohort	NN
cord-023439-r04y1j22	168	14	of	of	IN
cord-023439-r04y1j22	168	15	children	child	NNS
cord-023439-r04y1j22	168	16	living	live	VBG
cord-023439-r04y1j22	168	17	on	on	IN
cord-023439-r04y1j22	168	18	the	the	DT
cord-023439-r04y1j22	168	19	coast	coast	NN
cord-023439-r04y1j22	168	20	of	of	IN
cord-023439-r04y1j22	168	21	Kenya	Kenya	NNP
cord-023439-r04y1j22	168	22	.	.	.
cord-023439-r04y1j22	169	1	The	the	DT
cord-023439-r04y1j22	169	2	study	study	NN
cord-023439-r04y1j22	169	3	involved	involve	VBD
cord-023439-r04y1j22	169	4	longitudinal	longitudinal	JJ
cord-023439-r04y1j22	169	5	follow	follow	NN
cord-023439-r04y1j22	169	6	-	-	HYPH
cord-023439-r04y1j22	169	7	up	up	NN
cord-023439-r04y1j22	169	8	for	for	IN
cord-023439-r04y1j22	169	9	clinical	clinical	JJ
cord-023439-r04y1j22	169	10	malaria	malaria	NN
cord-023439-r04y1j22	169	11	episodes	episode	NNS
cord-023439-r04y1j22	169	12	and	and	CC
cord-023439-r04y1j22	169	13	anthropometric	anthropometric	JJ
cord-023439-r04y1j22	169	14	measurements	measurement	NNS
cord-023439-r04y1j22	169	15	at	at	IN
cord-023439-r04y1j22	169	16	four	four	CD
cord-023439-r04y1j22	169	17	cross	cross	JJ
cord-023439-r04y1j22	169	18	-	-	JJ
cord-023439-r04y1j22	169	19	sectional	sectional	JJ
cord-023439-r04y1j22	169	20	surveys	survey	NNS
cord-023439-r04y1j22	169	21	.	.	.
cord-023439-r04y1j22	170	1	We	-PRON-	PRP
cord-023439-r04y1j22	170	2	used	use	VBD
cord-023439-r04y1j22	170	3	Poisson	Poisson	NNP
cord-023439-r04y1j22	170	4	regression	regression	NN
cord-023439-r04y1j22	170	5	analysis	analysis	NN
cord-023439-r04y1j22	170	6	to	to	TO
cord-023439-r04y1j22	170	7	investigate	investigate	VB
cord-023439-r04y1j22	170	8	the	the	DT
cord-023439-r04y1j22	170	9	association	association	NN
cord-023439-r04y1j22	170	10	between	between	IN
cord-023439-r04y1j22	170	11	malaria	malaria	NNP
cord-023439-r04y1j22	170	12	and	and	CC
cord-023439-r04y1j22	170	13	nutritional	nutritional	JJ
cord-023439-r04y1j22	170	14	status	status	NN
cord-023439-r04y1j22	170	15	.	.	.
cord-023439-r04y1j22	171	1	Compared	compare	VBN
cord-023439-r04y1j22	171	2	to	to	IN
cord-023439-r04y1j22	171	3	baseline	baseline	JJ
cord-023439-r04y1j22	171	4	(	(	-LRB-
cord-023439-r04y1j22	171	5	children	child	NNS
cord-023439-r04y1j22	171	6	with	with	IN
cord-023439-r04y1j22	171	7	a	a	DT
cord-023439-r04y1j22	171	8	WAZ	WAZ	NNP
cord-023439-r04y1j22	171	9	or	or	CC
cord-023439-r04y1j22	171	10	HAZ	haz	NN
cord-023439-r04y1j22	171	11	score	score	NN
cord-023439-r04y1j22	171	12	of	of	IN
cord-023439-r04y1j22	171	13	!	!	.
cord-023439-r04y1j22	172	1	À2	À2	NNP
cord-023439-r04y1j22	172	2	)	)	-RRB-
cord-023439-r04y1j22	172	3	,	,	,
cord-023439-r04y1j22	172	4	the	the	DT
cord-023439-r04y1j22	172	5	crude	crude	JJ
cord-023439-r04y1j22	172	6	incidence	incidence	NN
cord-023439-r04y1j22	172	7	rate	rate	NN
cord-023439-r04y1j22	172	8	ratios	ratio	NNS
cord-023439-r04y1j22	172	9	(	(	-LRB-
cord-023439-r04y1j22	172	10	IRRs	IRRs	NNP
cord-023439-r04y1j22	172	11	)	)	-RRB-
cord-023439-r04y1j22	172	12	for	for	IN
cord-023439-r04y1j22	172	13	malaria	malaria	NN
cord-023439-r04y1j22	172	14	in	in	IN
cord-023439-r04y1j22	172	15	children	child	NNS
cord-023439-r04y1j22	172	16	with	with	IN
cord-023439-r04y1j22	172	17	low	low	JJ
cord-023439-r04y1j22	172	18	HAZ	haz	NN
cord-023439-r04y1j22	172	19	or	or	CC
cord-023439-r04y1j22	172	20	WAZ	WAZ	NNP
cord-023439-r04y1j22	172	21	scores	score	NNS
cord-023439-r04y1j22	172	22	(	(	-LRB-
cord-023439-r04y1j22	172	23	<	<	XX
cord-023439-r04y1j22	172	24	À2	À2	NNP
cord-023439-r04y1j22	172	25	)	)	-RRB-
cord-023439-r04y1j22	172	26	during	during	IN
cord-023439-r04y1j22	172	27	the	the	DT
cord-023439-r04y1j22	172	28	period	period	NN
cord-023439-r04y1j22	172	29	prior	prior	RB
cord-023439-r04y1j22	172	30	to	to	IN
cord-023439-r04y1j22	172	31	assessment	assessment	NN
cord-023439-r04y1j22	172	32	were	be	VBD
cord-023439-r04y1j22	172	33	1.17	1.17	CD
cord-023439-r04y1j22	173	1	(	(	-LRB-
cord-023439-r04y1j22	173	2	95	95	CD
cord-023439-r04y1j22	173	3	%	%	NN
cord-023439-r04y1j22	173	4	CI	CI	NNP
cord-023439-r04y1j22	173	5	0.91	0.91	CD
cord-023439-r04y1j22	173	6	-	-	HYPH
cord-023439-r04y1j22	173	7	1.50	1.50	CD
cord-023439-r04y1j22	173	8	;	;	:
cord-023439-r04y1j22	173	9	0	0	CD
cord-023439-r04y1j22	173	10	¼	¼	CD
cord-023439-r04y1j22	173	11	0.21	0.21	CD
cord-023439-r04y1j22	173	12	)	)	-RRB-
cord-023439-r04y1j22	173	13	and	and	CC
cord-023439-r04y1j22	173	14	0.94	0.94	CD
cord-023439-r04y1j22	173	15	(	(	-LRB-
cord-023439-r04y1j22	173	16	0.71	0.71	CD
cord-023439-r04y1j22	173	17	-	-	SYM
cord-023439-r04y1j22	173	18	1.25	1.25	CD
cord-023439-r04y1j22	173	19	;	;	:
cord-023439-r04y1j22	173	20	0.67	0.67	CD
cord-023439-r04y1j22	173	21	)	)	-RRB-
cord-023439-r04y1j22	173	22	,	,	,
cord-023439-r04y1j22	173	23	respectively	respectively	RB
cord-023439-r04y1j22	173	24	,	,	,
cord-023439-r04y1j22	173	25	suggesting	suggest	VBG
cord-023439-r04y1j22	173	26	no	no	DT
cord-023439-r04y1j22	173	27	association	association	NN
cord-023439-r04y1j22	173	28	between	between	IN
cord-023439-r04y1j22	173	29	malaria	malaria	NN
cord-023439-r04y1j22	173	30	and	and	CC
cord-023439-r04y1j22	173	31	the	the	DT
cord-023439-r04y1j22	173	32	subsequent	subsequent	JJ
cord-023439-r04y1j22	173	33	development	development	NN
cord-023439-r04y1j22	173	34	of	of	IN
cord-023439-r04y1j22	173	35	PEM	PEM	NNP
cord-023439-r04y1j22	173	36	.	.	.
cord-023439-r04y1j22	174	1	However	however	RB
cord-023439-r04y1j22	174	2	,	,	,
cord-023439-r04y1j22	174	3	we	-PRON-	PRP
cord-023439-r04y1j22	174	4	found	find	VBD
cord-023439-r04y1j22	174	5	that	that	IN
cord-023439-r04y1j22	174	6	age	age	NN
cord-023439-r04y1j22	174	7	was	be	VBD
cord-023439-r04y1j22	174	8	acting	act	VBG
cord-023439-r04y1j22	174	9	as	as	IN
cord-023439-r04y1j22	174	10	an	an	DT
cord-023439-r04y1j22	174	11	effect	effect	NN
cord-023439-r04y1j22	174	12	modifier	modifier	NN
cord-023439-r04y1j22	174	13	in	in	IN
cord-023439-r04y1j22	174	14	the	the	DT
cord-023439-r04y1j22	174	15	association	association	NN
cord-023439-r04y1j22	174	16	between	between	IN
cord-023439-r04y1j22	174	17	malaria	malaria	NN
cord-023439-r04y1j22	174	18	and	and	CC
cord-023439-r04y1j22	174	19	malnutrition	malnutrition	NN
cord-023439-r04y1j22	174	20	.	.	.
cord-023439-r04y1j22	175	1	The	the	DT
cord-023439-r04y1j22	175	2	IRR	IRR	NNP
cord-023439-r04y1j22	175	3	for	for	IN
cord-023439-r04y1j22	175	4	malaria	malaria	NN
cord-023439-r04y1j22	175	5	in	in	IN
cord-023439-r04y1j22	175	6	children	child	NNS
cord-023439-r04y1j22	175	7	0	0	CD
cord-023439-r04y1j22	175	8	-	-	SYM
cord-023439-r04y1j22	175	9	2	2	CD
cord-023439-r04y1j22	175	10	years	year	NNS
cord-023439-r04y1j22	175	11	old	old	JJ
cord-023439-r04y1j22	175	12	who	who	WP
cord-023439-r04y1j22	175	13	were	be	VBD
cord-023439-r04y1j22	175	14	subsequently	subsequently	RB
cord-023439-r04y1j22	175	15	characterized	characterize	VBN
cord-023439-r04y1j22	175	16	as	as	IN
cord-023439-r04y1j22	175	17	wasted	waste	VBN
cord-023439-r04y1j22	175	18	was	be	VBD
cord-023439-r04y1j22	175	19	1.65	1.65	CD
cord-023439-r04y1j22	175	20	(	(	-LRB-
cord-023439-r04y1j22	175	21	1.10	1.10	CD
cord-023439-r04y1j22	175	22	-	-	SYM
cord-023439-r04y1j22	175	23	2.20	2.20	CD
cord-023439-r04y1j22	175	24	;	;	.
cord-023439-r04y1j22	176	1	P	p	NN
cord-023439-r04y1j22	176	2	¼	¼	CD
cord-023439-r04y1j22	176	3	0.01	0.01	CD
cord-023439-r04y1j22	176	4	)	)	-RRB-
cord-023439-r04y1j22	176	5	,	,	,
cord-023439-r04y1j22	176	6	and	and	CC
cord-023439-r04y1j22	177	1	a	a	DT
cord-023439-r04y1j22	177	2	significant	significant	JJ
cord-023439-r04y1j22	177	3	overall	overall	JJ
cord-023439-r04y1j22	177	4	relationship	relationship	NN
cord-023439-r04y1j22	177	5	between	between	IN
cord-023439-r04y1j22	177	6	malaria	malaria	NN
cord-023439-r04y1j22	177	7	and	and	CC
cord-023439-r04y1j22	177	8	low	low	JJ
cord-023439-r04y1j22	177	9	-	-	HYPH
cord-023439-r04y1j22	177	10	HAZ	haz	NN
cord-023439-r04y1j22	177	11	was	be	VBD
cord-023439-r04y1j22	177	12	found	find	VBN
cord-023439-r04y1j22	177	13	on	on	IN
cord-023439-r04y1j22	177	14	regression	regression	NN
cord-023439-r04y1j22	177	15	analysis	analysis	NN
cord-023439-r04y1j22	177	16	when	when	WRB
cord-023439-r04y1j22	177	17	adjusting	adjust	VBG
cord-023439-r04y1j22	177	18	for	for	IN
cord-023439-r04y1j22	177	19	the	the	DT
cord-023439-r04y1j22	177	20	interaction	interaction	NN
cord-023439-r04y1j22	177	21	with	with	IN
cord-023439-r04y1j22	177	22	age	age	NN
cord-023439-r04y1j22	177	23	(	(	-LRB-
cord-023439-r04y1j22	177	24	IRR	IRR	NNP
cord-023439-r04y1j22	177	25	1.89	1.89	CD
cord-023439-r04y1j22	177	26	;	;	:
cord-023439-r04y1j22	177	27	1.01	1.01	CD
cord-023439-r04y1j22	177	28	-	-	HYPH
cord-023439-r04y1j22	177	29	3.53	3.53	CD
cord-023439-r04y1j22	177	30	;	;	:
cord-023439-r04y1j22	177	31	P	p	NN
cord-023439-r04y1j22	177	32	<	<	XX
cord-023439-r04y1j22	177	33	0.05	0.05	CD
cord-023439-r04y1j22	177	34	)	)	-RRB-
cord-023439-r04y1j22	177	35	.	.	.
cord-023439-r04y1j22	178	1	Although	although	IN
cord-023439-r04y1j22	178	2	children	child	NNS
cord-023439-r04y1j22	178	3	living	live	VBG
cord-023439-r04y1j22	178	4	on	on	IN
cord-023439-r04y1j22	178	5	the	the	DT
cord-023439-r04y1j22	178	6	coast	coast	NN
cord-023439-r04y1j22	178	7	of	of	IN
cord-023439-r04y1j22	178	8	Kenya	Kenya	NNP
cord-023439-r04y1j22	178	9	continue	continue	VBP
cord-023439-r04y1j22	178	10	to	to	TO
cord-023439-r04y1j22	178	11	suffer	suffer	VB
cord-023439-r04y1j22	178	12	clinical	clinical	JJ
cord-023439-r04y1j22	178	13	episodes	episode	NNS
cord-023439-r04y1j22	178	14	of	of	IN
cord-023439-r04y1j22	178	15	uncomplicated	uncomplicated	JJ
cord-023439-r04y1j22	178	16	malaria	malaria	NN
cord-023439-r04y1j22	178	17	throughout	throughout	IN
cord-023439-r04y1j22	178	18	their	-PRON-	PRP$
cord-023439-r04y1j22	178	19	first	first	JJ
cord-023439-r04y1j22	178	20	decade	decade	NN
cord-023439-r04y1j22	178	21	,	,	,
cord-023439-r04y1j22	178	22	the	the	DT
cord-023439-r04y1j22	178	23	association	association	NN
cord-023439-r04y1j22	178	24	between	between	IN
cord-023439-r04y1j22	178	25	malaria	malaria	NN
cord-023439-r04y1j22	178	26	and	and	CC
cord-023439-r04y1j22	178	27	malnutrition	malnutrition	NN
cord-023439-r04y1j22	178	28	appears	appear	VBZ
cord-023439-r04y1j22	178	29	to	to	TO
cord-023439-r04y1j22	178	30	be	be	VB
cord-023439-r04y1j22	178	31	limited	limit	VBN
cord-023439-r04y1j22	178	32	to	to	IN
cord-023439-r04y1j22	178	33	the	the	DT
cord-023439-r04y1j22	178	34	first	first	JJ
cord-023439-r04y1j22	178	35	2	2	CD
cord-023439-r04y1j22	178	36	years	year	NNS
cord-023439-r04y1j22	178	37	of	of	IN
cord-023439-r04y1j22	178	38	life	life	NN
cord-023439-r04y1j22	178	39	.	.	.
cord-023439-r04y1j22	179	1	A.	A.	NNP
cord-023439-r04y1j22	179	2	Astrinidou	Astrinidou	NNP
cord-023439-r04y1j22	179	3	-	-	HYPH
cord-023439-r04y1j22	179	4	Vakaloudi	Vakaloudi	NNP
cord-023439-r04y1j22	179	5	,	,	,
cord-023439-r04y1j22	179	6	1	1	CD
cord-023439-r04y1j22	179	7	S.	S.	NNP
cord-023439-r04y1j22	179	8	Xytsas	Xytsas	NNP
cord-023439-r04y1j22	179	9	,	,	,
cord-023439-r04y1j22	179	10	1	1	CD
cord-023439-r04y1j22	179	11	I.	i.	NN
cord-023439-r04y1j22	179	12	Diamanti	Diamanti	NNP
cord-023439-r04y1j22	179	13	,	,	,
cord-023439-r04y1j22	179	14	1	1	CD
cord-023439-r04y1j22	179	15	H.	H.	NNP
cord-023439-r04y1j22	179	16	Ioannidis	Ioannidis	NNP
cord-023439-r04y1j22	179	17	2	2	CD
cord-023439-r04y1j22	179	18	&	&	CC
cord-023439-r04y1j22	179	19	P.	P.	NNP
cord-023439-r04y1j22	179	20	Pangidis	Pangidis	NNP
cord-023439-r04y1j22	179	21	2	2	CD
cord-023439-r04y1j22	179	22	1	1	CD
cord-023439-r04y1j22	179	23	Microbiology	Microbiology	NNP
cord-023439-r04y1j22	179	24	Department	Department	NNP
cord-023439-r04y1j22	179	25	of	of	IN
cord-023439-r04y1j22	179	26	General	General	NNP
cord-023439-r04y1j22	179	27	Hospital	Hospital	NNP
cord-023439-r04y1j22	179	28	of	of	IN
cord-023439-r04y1j22	179	29	Thessaloniki	Thessaloniki	NNP
cord-023439-r04y1j22	179	30	'	'	POS
cord-023439-r04y1j22	179	31	Agios	Agios	NNP
cord-023439-r04y1j22	179	32	Pavlos	Pavlos	NNP
cord-023439-r04y1j22	179	33	'	'	POS
cord-023439-r04y1j22	179	34	,	,	,
cord-023439-r04y1j22	179	35	Thessaloniki	Thessaloniki	NNP
cord-023439-r04y1j22	179	36	,	,	,
cord-023439-r04y1j22	179	37	Greece	Greece	NNP
cord-023439-r04y1j22	179	38	,	,	,
cord-023439-r04y1j22	179	39	and	and	CC
cord-023439-r04y1j22	179	40	2	2	CD
cord-023439-r04y1j22	179	41	Nefrology	Nefrology	NNP
cord-023439-r04y1j22	179	42	,	,	,
cord-023439-r04y1j22	179	43	2	2	CD
cord-023439-r04y1j22	179	44	nd	nd	NNP
cord-023439-r04y1j22	179	45	IKA	IKA	NNP
cord-023439-r04y1j22	179	46	Hospital	Hospital	NNP
cord-023439-r04y1j22	179	47	of	of	IN
cord-023439-r04y1j22	179	48	Thessaloniki	Thessaloniki	NNP
cord-023439-r04y1j22	179	49	,	,	,
cord-023439-r04y1j22	179	50	Thessaloniki	Thessaloniki	NNP
cord-023439-r04y1j22	179	51	,	,	,
cord-023439-r04y1j22	179	52	Greece	Greece	NNP
cord-023439-r04y1j22	179	53	.	.	.
cord-023439-r04y1j22	180	1	E	e	NN
cord-023439-r04y1j22	180	2	-	-	NN
cord-023439-r04y1j22	180	3	mail	mail	NN
cord-023439-r04y1j22	180	4	:	:	:
cord-023439-r04y1j22	180	5	stasa@hol.gr	stasa@hol.gr	NNP
cord-023439-r04y1j22	180	6	Aim	aim	VB
cord-023439-r04y1j22	180	7	:	:	:
cord-023439-r04y1j22	180	8	Renal	renal	JJ
cord-023439-r04y1j22	180	9	dysfunction	dysfunction	NN
cord-023439-r04y1j22	180	10	may	may	MD
cord-023439-r04y1j22	180	11	influence	influence	VB
cord-023439-r04y1j22	180	12	the	the	DT
cord-023439-r04y1j22	180	13	colonization	colonization	NN
cord-023439-r04y1j22	180	14	of	of	IN
cord-023439-r04y1j22	180	15	gastric	gastric	JJ
cord-023439-r04y1j22	180	16	mucosa	mucosa	NN
cord-023439-r04y1j22	180	17	by	by	IN
cord-023439-r04y1j22	180	18	urea	urea	NN
cord-023439-r04y1j22	180	19	-	-	HYPH
cord-023439-r04y1j22	180	20	splitting	split	VBG
cord-023439-r04y1j22	180	21	bacteria	bacteria	NNS
cord-023439-r04y1j22	180	22	such	such	JJ
cord-023439-r04y1j22	180	23	as	as	IN
cord-023439-r04y1j22	180	24	Helicobacter	Helicobacter	NNP
cord-023439-r04y1j22	180	25	pylori	pylori	NN
cord-023439-r04y1j22	180	26	,	,	,
cord-023439-r04y1j22	180	27	by	by	IN
cord-023439-r04y1j22	180	28	increasing	increase	VBG
cord-023439-r04y1j22	180	29	urea	urea	NN
cord-023439-r04y1j22	180	30	concentrations	concentration	NNS
cord-023439-r04y1j22	180	31	in	in	IN
cord-023439-r04y1j22	180	32	the	the	DT
cord-023439-r04y1j22	180	33	gastric	gastric	JJ
cord-023439-r04y1j22	180	34	juice	juice	NN
cord-023439-r04y1j22	180	35	.	.	.
cord-023439-r04y1j22	181	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	181	2	aim	aim	NN
cord-023439-r04y1j22	181	3	was	be	VBD
cord-023439-r04y1j22	181	4	to	to	TO
cord-023439-r04y1j22	181	5	investigate	investigate	VB
cord-023439-r04y1j22	181	6	the	the	DT
cord-023439-r04y1j22	181	7	prevalence	prevalence	NN
cord-023439-r04y1j22	181	8	of	of	IN
cord-023439-r04y1j22	181	9	H.	h.	NN
cord-023439-r04y1j22	181	10	pylori	pylori	NN
cord-023439-r04y1j22	181	11	in	in	IN
cord-023439-r04y1j22	181	12	patients	patient	NNS
cord-023439-r04y1j22	181	13	with	with	IN
cord-023439-r04y1j22	181	14	end	end	NN
cord-023439-r04y1j22	181	15	-	-	HYPH
cord-023439-r04y1j22	181	16	stage	stage	NN
cord-023439-r04y1j22	181	17	renal	renal	JJ
cord-023439-r04y1j22	181	18	disease	disease	NN
cord-023439-r04y1j22	181	19	(	(	-LRB-
cord-023439-r04y1j22	181	20	ESRD	ESRD	NNP
cord-023439-r04y1j22	181	21	)	)	-RRB-
cord-023439-r04y1j22	181	22	,	,	,
cord-023439-r04y1j22	181	23	receiving	receive	VBG
cord-023439-r04y1j22	181	24	long	long	JJ
cord-023439-r04y1j22	181	25	-	-	HYPH
cord-023439-r04y1j22	181	26	term	term	NN
cord-023439-r04y1j22	181	27	haemodialysis	haemodialysis	NN
cord-023439-r04y1j22	181	28	treatment	treatment	NN
cord-023439-r04y1j22	181	29	.	.	.
cord-023439-r04y1j22	182	1	Methods	method	NNS
cord-023439-r04y1j22	182	2	:	:	:
cord-023439-r04y1j22	183	1	This	this	DT
cord-023439-r04y1j22	183	2	study	study	NN
cord-023439-r04y1j22	183	3	included	include	VBD
cord-023439-r04y1j22	183	4	40	40	CD
cord-023439-r04y1j22	183	5	sera	sera	NNP
cord-023439-r04y1j22	183	6	from	from	IN
cord-023439-r04y1j22	183	7	patients	patient	NNS
cord-023439-r04y1j22	183	8	with	with	IN
cord-023439-r04y1j22	183	9	ESRD	ESRD	NNP
cord-023439-r04y1j22	183	10	(	(	-LRB-
cord-023439-r04y1j22	183	11	29	29	CD
cord-023439-r04y1j22	183	12	male	male	NN
cord-023439-r04y1j22	183	13	and	and	CC
cord-023439-r04y1j22	183	14	11	11	CD
cord-023439-r04y1j22	183	15	female	female	JJ
cord-023439-r04y1j22	183	16	)	)	-RRB-
cord-023439-r04y1j22	183	17	undergoing	undergo	VBG
cord-023439-r04y1j22	183	18	periodic	periodic	JJ
cord-023439-r04y1j22	183	19	haemodialysis	haemodialysis	NN
cord-023439-r04y1j22	183	20	;	;	:
cord-023439-r04y1j22	183	21	mean	mean	JJ
cord-023439-r04y1j22	183	22	time	time	NN
cord-023439-r04y1j22	183	23	of	of	IN
cord-023439-r04y1j22	183	24	treatment	treatment	NN
cord-023439-r04y1j22	183	25	was	be	VBD
cord-023439-r04y1j22	183	26	42.6	42.6	CD
cord-023439-r04y1j22	183	27	months	month	NNS
cord-023439-r04y1j22	183	28	.	.	.
cord-023439-r04y1j22	184	1	Using	use	VBG
cord-023439-r04y1j22	184	2	ELISA	ELISA	NNP
cord-023439-r04y1j22	184	3	technique	technique	NN
cord-023439-r04y1j22	184	4	,	,	,
cord-023439-r04y1j22	184	5	we	-PRON-	PRP
cord-023439-r04y1j22	184	6	investigated	investigate	VBD
cord-023439-r04y1j22	184	7	the	the	DT
cord-023439-r04y1j22	184	8	presence	presence	NN
cord-023439-r04y1j22	184	9	of	of	IN
cord-023439-r04y1j22	184	10	IgG	IgG	NNP
cord-023439-r04y1j22	184	11	and	and	CC
cord-023439-r04y1j22	184	12	IgA	IgA	NNP
cord-023439-r04y1j22	184	13	antibodies	antibody	NNS
cord-023439-r04y1j22	184	14	against	against	IN
cord-023439-r04y1j22	184	15	H.	H.	NNP
cord-023439-r04y1j22	184	16	pylori	pylori	NN
cord-023439-r04y1j22	184	17	as	as	RB
cord-023439-r04y1j22	184	18	well	well	RB
cord-023439-r04y1j22	184	19	as	as	IN
cord-023439-r04y1j22	184	20	IgG	IgG	NNP
cord-023439-r04y1j22	184	21	CagA	CagA	NNP
cord-023439-r04y1j22	184	22	(	(	-LRB-
cord-023439-r04y1j22	184	23	antibodies	antibody	NNS
cord-023439-r04y1j22	184	24	specific	specific	JJ
cord-023439-r04y1j22	184	25	for	for	IN
cord-023439-r04y1j22	184	26	CagA(þ	CagA(þ	NNS
cord-023439-r04y1j22	184	27	)	)	-RRB-
cord-023439-r04y1j22	184	28	strains	strain	NNS
cord-023439-r04y1j22	184	29	of	of	IN
cord-023439-r04y1j22	184	30	H.	H.	NNP
cord-023439-r04y1j22	184	31	pylori	pylori	NN
cord-023439-r04y1j22	184	32	)	)	-RRB-
cord-023439-r04y1j22	184	33	.	.	.
cord-023439-r04y1j22	185	1	Sera	Sera	NNP
cord-023439-r04y1j22	185	2	from	from	IN
cord-023439-r04y1j22	185	3	40	40	CD
cord-023439-r04y1j22	185	4	healthy	healthy	JJ
cord-023439-r04y1j22	185	5	blood	blood	NN
cord-023439-r04y1j22	185	6	donors	donor	NNS
cord-023439-r04y1j22	185	7	were	be	VBD
cord-023439-r04y1j22	185	8	used	use	VBN
cord-023439-r04y1j22	185	9	as	as	IN
cord-023439-r04y1j22	185	10	a	a	DT
cord-023439-r04y1j22	185	11	control	control	NN
cord-023439-r04y1j22	185	12	group	group	NN
cord-023439-r04y1j22	185	13	.	.	.
cord-023439-r04y1j22	186	1	Results	result	NNS
cord-023439-r04y1j22	186	2	:	:	:
cord-023439-r04y1j22	187	1	H.	H.	NNP
cord-023439-r04y1j22	187	2	pylori	pylori	NNP
cord-023439-r04y1j22	187	3	IgG	IgG	NNP
cord-023439-r04y1j22	187	4	antibodies	antibody	NNS
cord-023439-r04y1j22	187	5	were	be	VBD
cord-023439-r04y1j22	187	6	detected	detect	VBN
cord-023439-r04y1j22	187	7	in	in	IN
cord-023439-r04y1j22	187	8	32	32	CD
cord-023439-r04y1j22	187	9	out	out	IN
cord-023439-r04y1j22	187	10	of	of	IN
cord-023439-r04y1j22	187	11	40	40	CD
cord-023439-r04y1j22	187	12	(	(	-LRB-
cord-023439-r04y1j22	187	13	80	80	CD
cord-023439-r04y1j22	187	14	%	%	NN
cord-023439-r04y1j22	187	15	)	)	-RRB-
cord-023439-r04y1j22	187	16	patients	patient	NNS
cord-023439-r04y1j22	187	17	in	in	IN
cord-023439-r04y1j22	187	18	the	the	DT
cord-023439-r04y1j22	187	19	dialysis	dialysis	NN
cord-023439-r04y1j22	187	20	group	group	NN
cord-023439-r04y1j22	187	21	,	,	,
cord-023439-r04y1j22	187	22	while	while	IN
cord-023439-r04y1j22	187	23	31/40	31/40	CD
cord-023439-r04y1j22	187	24	(	(	-LRB-
cord-023439-r04y1j22	187	25	77.5	77.5	CD
cord-023439-r04y1j22	187	26	%	%	NN
cord-023439-r04y1j22	187	27	)	)	-RRB-
cord-023439-r04y1j22	187	28	tested	test	VBD
cord-023439-r04y1j22	187	29	positive	positive	JJ
cord-023439-r04y1j22	187	30	for	for	IN
cord-023439-r04y1j22	188	1	IgA.	IgA.	NNP
cord-023439-r04y1j22	189	1	IgG	IgG	NNP
cord-023439-r04y1j22	189	2	CagA	CagA	NNP
cord-023439-r04y1j22	189	3	antibodies	antibody	NNS
cord-023439-r04y1j22	189	4	were	be	VBD
cord-023439-r04y1j22	189	5	present	present	JJ
cord-023439-r04y1j22	189	6	in	in	IN
cord-023439-r04y1j22	189	7	13	13	CD
cord-023439-r04y1j22	189	8	out	out	IN
cord-023439-r04y1j22	189	9	of	of	IN
cord-023439-r04y1j22	189	10	40	40	CD
cord-023439-r04y1j22	189	11	(	(	-LRB-
cord-023439-r04y1j22	189	12	32.5	32.5	CD
cord-023439-r04y1j22	189	13	%	%	NN
cord-023439-r04y1j22	189	14	)	)	-RRB-
cord-023439-r04y1j22	189	15	.	.	.
cord-023439-r04y1j22	190	1	Prevalence	prevalence	NN
cord-023439-r04y1j22	190	2	of	of	IN
cord-023439-r04y1j22	190	3	H.	H.	NNP
cord-023439-r04y1j22	190	4	pylori	pylori	NNP
cord-023439-r04y1j22	190	5	IgG	IgG	NNP
cord-023439-r04y1j22	190	6	,	,	,
cord-023439-r04y1j22	190	7	IgA	IgA	NNP
cord-023439-r04y1j22	190	8	and	and	CC
cord-023439-r04y1j22	190	9	CagA	CagA	NNP
cord-023439-r04y1j22	190	10	IgG	IgG	NNP
cord-023439-r04y1j22	190	11	antibodies	antibody	NNS
cord-023439-r04y1j22	190	12	in	in	IN
cord-023439-r04y1j22	190	13	the	the	DT
cord-023439-r04y1j22	190	14	control	control	NN
cord-023439-r04y1j22	190	15	group	group	NN
cord-023439-r04y1j22	190	16	was	be	VBD
cord-023439-r04y1j22	190	17	33	33	CD
cord-023439-r04y1j22	190	18	,	,	,
cord-023439-r04y1j22	190	19	7	7	CD
cord-023439-r04y1j22	190	20	and	and	CC
cord-023439-r04y1j22	190	21	15	15	CD
cord-023439-r04y1j22	190	22	%	%	NN
cord-023439-r04y1j22	190	23	,	,	,
cord-023439-r04y1j22	190	24	respectively	respectively	RB
cord-023439-r04y1j22	190	25	.	.	.
cord-023439-r04y1j22	191	1	Conclusions	conclusion	NNS
cord-023439-r04y1j22	191	2	:	:	:
cord-023439-r04y1j22	192	1	Although	although	IN
cord-023439-r04y1j22	192	2	international	international	JJ
cord-023439-r04y1j22	192	3	data	datum	NNS
cord-023439-r04y1j22	192	4	suggest	suggest	VBP
cord-023439-r04y1j22	192	5	that	that	IN
cord-023439-r04y1j22	192	6	prevalence	prevalence	NN
cord-023439-r04y1j22	192	7	of	of	IN
cord-023439-r04y1j22	192	8	H.	h.	NN
cord-023439-r04y1j22	192	9	pylori	pylori	NN
cord-023439-r04y1j22	192	10	infection	infection	NN
cord-023439-r04y1j22	192	11	is	be	VBZ
cord-023439-r04y1j22	192	12	the	the	DT
cord-023439-r04y1j22	192	13	same	same	JJ
cord-023439-r04y1j22	192	14	in	in	IN
cord-023439-r04y1j22	192	15	ESRD	ESRD	NNP
cord-023439-r04y1j22	192	16	patients	patient	NNS
cord-023439-r04y1j22	192	17	as	as	IN
cord-023439-r04y1j22	192	18	in	in	IN
cord-023439-r04y1j22	192	19	healthy	healthy	JJ
cord-023439-r04y1j22	192	20	individuals	individual	NNS
cord-023439-r04y1j22	192	21	,	,	,
cord-023439-r04y1j22	192	22	in	in	IN
cord-023439-r04y1j22	192	23	our	-PRON-	PRP$
cord-023439-r04y1j22	192	24	study	study	NN
cord-023439-r04y1j22	192	25	that	that	WDT
cord-023439-r04y1j22	192	26	seems	seem	VBZ
cord-023439-r04y1j22	192	27	not	not	RB
cord-023439-r04y1j22	192	28	to	to	TO
cord-023439-r04y1j22	192	29	be	be	VB
cord-023439-r04y1j22	192	30	the	the	DT
cord-023439-r04y1j22	192	31	case	case	NN
cord-023439-r04y1j22	192	32	.	.	.
cord-023439-r04y1j22	193	1	The	the	DT
cord-023439-r04y1j22	193	2	higher	high	JJR
cord-023439-r04y1j22	193	3	blood	blood	NN
cord-023439-r04y1j22	193	4	and	and	CC
cord-023439-r04y1j22	193	5	gastric	gastric	JJ
cord-023439-r04y1j22	193	6	juice	juice	NN
cord-023439-r04y1j22	193	7	urea	urea	NN
cord-023439-r04y1j22	193	8	levels	level	NNS
cord-023439-r04y1j22	193	9	may	may	MD
cord-023439-r04y1j22	193	10	be	be	VB
cord-023439-r04y1j22	193	11	a	a	DT
cord-023439-r04y1j22	193	12	risk	risk	NN
cord-023439-r04y1j22	193	13	factor	factor	NN
cord-023439-r04y1j22	193	14	(	(	-LRB-
cord-023439-r04y1j22	193	15	among	among	IN
cord-023439-r04y1j22	193	16	many	many	JJ
cord-023439-r04y1j22	193	17	others	other	NNS
cord-023439-r04y1j22	193	18	)	)	-RRB-
cord-023439-r04y1j22	193	19	,	,	,
cord-023439-r04y1j22	193	20	but	but	CC
cord-023439-r04y1j22	193	21	more	more	JJR
cord-023439-r04y1j22	193	22	studies	study	NNS
cord-023439-r04y1j22	193	23	are	be	VBP
cord-023439-r04y1j22	193	24	required	require	VBN
cord-023439-r04y1j22	193	25	in	in	IN
cord-023439-r04y1j22	193	26	order	order	NN
cord-023439-r04y1j22	193	27	to	to	TO
cord-023439-r04y1j22	193	28	understand	understand	VB
cord-023439-r04y1j22	193	29	the	the	DT
cord-023439-r04y1j22	193	30	relation	relation	NN
cord-023439-r04y1j22	193	31	of	of	IN
cord-023439-r04y1j22	193	32	H.	H.	NNP
cord-023439-r04y1j22	193	33	pylori	pylori	NN
cord-023439-r04y1j22	193	34	infection	infection	NN
cord-023439-r04y1j22	193	35	in	in	IN
cord-023439-r04y1j22	193	36	this	this	DT
cord-023439-r04y1j22	193	37	group	group	NN
cord-023439-r04y1j22	193	38	of	of	IN
cord-023439-r04y1j22	193	39	patients	patient	NNS
cord-023439-r04y1j22	193	40	.	.	.
cord-023439-r04y1j22	194	1	Flanders	Flanders	NNP
cord-023439-r04y1j22	194	2	Interuniversity	Interuniversity	NNP
cord-023439-r04y1j22	194	3	Institute	Institute	NNP
cord-023439-r04y1j22	194	4	for	for	IN
cord-023439-r04y1j22	194	5	Biotechnology	Biotechnology	NNP
cord-023439-r04y1j22	194	6	,	,	,
cord-023439-r04y1j22	194	7	Department	Department	NNP
cord-023439-r04y1j22	194	8	of	of	IN
cord-023439-r04y1j22	194	9	Molecular	Molecular	NNP
cord-023439-r04y1j22	194	10	and	and	CC
cord-023439-r04y1j22	194	11	Cellular	Cellular	NNP
cord-023439-r04y1j22	194	12	Interactions	Interactions	NNPS
cord-023439-r04y1j22	194	13	,	,	,
cord-023439-r04y1j22	194	14	Free	Free	NNP
cord-023439-r04y1j22	194	15	University	University	NNP
cord-023439-r04y1j22	194	16	of	of	IN
cord-023439-r04y1j22	194	17	Brussels	Brussels	NNP
cord-023439-r04y1j22	194	18	,	,	,
cord-023439-r04y1j22	194	19	Brussels	Brussels	NNP
cord-023439-r04y1j22	194	20	,	,	,
cord-023439-r04y1j22	194	21	and	and	CC
cord-023439-r04y1j22	194	22	2	2	CD
cord-023439-r04y1j22	194	23	Pasteur	Pasteur	NNP
cord-023439-r04y1j22	194	24	Institute	Institute	NNP
cord-023439-r04y1j22	194	25	of	of	IN
cord-023439-r04y1j22	194	26	Brussels	Brussels	NNP
cord-023439-r04y1j22	194	27	,	,	,
cord-023439-r04y1j22	194	28	Mycobacterial	Mycobacterial	NNP
cord-023439-r04y1j22	194	29	Immunology	Immunology	NNP
cord-023439-r04y1j22	194	30	,	,	,
cord-023439-r04y1j22	194	31	Brussels	Brussels	NNP
cord-023439-r04y1j22	194	32	,	,	,
cord-023439-r04y1j22	194	33	Belgium	Belgium	NNP
cord-023439-r04y1j22	194	34	.	.	.
cord-023439-r04y1j22	195	1	E	e	NN
cord-023439-r04y1j22	195	2	-	-	NN
cord-023439-r04y1j22	195	3	mail	mail	NN
cord-023439-r04y1j22	195	4	:	:	:
cord-023439-r04y1j22	195	5	tgartner@vub.ac.be	tgartner@vub.ac.be	ADD
cord-023439-r04y1j22	195	6	Immunity	immunity	NN
cord-023439-r04y1j22	195	7	against	against	IN
cord-023439-r04y1j22	195	8	tuberculosis	tuberculosis	NN
cord-023439-r04y1j22	195	9	(	(	-LRB-
cord-023439-r04y1j22	195	10	TB	TB	NNP
cord-023439-r04y1j22	195	11	)	)	-RRB-
cord-023439-r04y1j22	195	12	,	,	,
cord-023439-r04y1j22	195	13	caused	cause	VBN
cord-023439-r04y1j22	195	14	by	by	IN
cord-023439-r04y1j22	195	15	Mycobacterium	Mycobacterium	NNP
cord-023439-r04y1j22	195	16	tuberculosis	tuberculosis	NN
cord-023439-r04y1j22	195	17	,	,	,
cord-023439-r04y1j22	195	18	depends	depend	VBZ
cord-023439-r04y1j22	195	19	largely	largely	RB
cord-023439-r04y1j22	195	20	on	on	IN
cord-023439-r04y1j22	195	21	activation	activation	NN
cord-023439-r04y1j22	195	22	and	and	CC
cord-023439-r04y1j22	195	23	maintenance	maintenance	NN
cord-023439-r04y1j22	195	24	of	of	IN
cord-023439-r04y1j22	195	25	strong	strong	JJ
cord-023439-r04y1j22	195	26	cell	cell	NN
cord-023439-r04y1j22	195	27	-	-	HYPH
cord-023439-r04y1j22	195	28	mediated	mediate	VBN
cord-023439-r04y1j22	195	29	immune	immune	JJ
cord-023439-r04y1j22	195	30	responses	response	NNS
cord-023439-r04y1j22	195	31	involving	involve	VBG
cord-023439-r04y1j22	195	32	both	both	CC
cord-023439-r04y1j22	195	33	CD4	CD4	NNP
cord-023439-r04y1j22	195	34	þ	þ	NNP
cord-023439-r04y1j22	195	35	and	and	CC
cord-023439-r04y1j22	195	36	CD8	CD8	NNP
cord-023439-r04y1j22	195	37	þ	þ	NNP
cord-023439-r04y1j22	195	38	T	T	NNP
cord-023439-r04y1j22	195	39	cells	cell	NNS
cord-023439-r04y1j22	195	40	and	and	CC
cord-023439-r04y1j22	195	41	the	the	DT
cord-023439-r04y1j22	195	42	ability	ability	NN
cord-023439-r04y1j22	195	43	to	to	TO
cord-023439-r04y1j22	195	44	respond	respond	VB
cord-023439-r04y1j22	195	45	with	with	IN
cord-023439-r04y1j22	195	46	Th1-type	Th1-type	NNP
cord-023439-r04y1j22	195	47	cytokines	cytokine	NNS
cord-023439-r04y1j22	195	48	,	,	,
cord-023439-r04y1j22	195	49	particularly	particularly	RB
cord-023439-r04y1j22	195	50	IFN	IFN	NNP
cord-023439-r04y1j22	195	51	-	-	HYPH
cord-023439-r04y1j22	195	52	g	g	NNP
cord-023439-r04y1j22	195	53	.	.	.
cord-023439-r04y1j22	196	1	Recent	recent	JJ
cord-023439-r04y1j22	196	2	studies	study	NNS
cord-023439-r04y1j22	196	3	suggested	suggest	VBD
cord-023439-r04y1j22	196	4	that	that	IN
cord-023439-r04y1j22	196	5	BCG	BCG	NNP
cord-023439-r04y1j22	196	6	,	,	,
cord-023439-r04y1j22	196	7	the	the	DT
cord-023439-r04y1j22	196	8	only	only	JJ
cord-023439-r04y1j22	196	9	licensed	licensed	JJ
cord-023439-r04y1j22	196	10	vaccine	vaccine	NN
cord-023439-r04y1j22	196	11	against	against	IN
cord-023439-r04y1j22	196	12	M.	M.	NNP
cord-023439-r04y1j22	196	13	tuberculosis	tuberculosis	NN
cord-023439-r04y1j22	196	14	,	,	,
cord-023439-r04y1j22	196	15	may	may	MD
cord-023439-r04y1j22	196	16	fail	fail	VB
cord-023439-r04y1j22	196	17	to	to	TO
cord-023439-r04y1j22	196	18	induce	induce	VB
cord-023439-r04y1j22	196	19	T	t	NN
cord-023439-r04y1j22	196	20	-	-	HYPH
cord-023439-r04y1j22	196	21	cell	cell	NN
cord-023439-r04y1j22	196	22	responses	response	NNS
cord-023439-r04y1j22	196	23	in	in	IN
cord-023439-r04y1j22	196	24	the	the	DT
cord-023439-r04y1j22	196	25	lung	lung	NN
cord-023439-r04y1j22	196	26	mucosa	mucosa	NN
cord-023439-r04y1j22	196	27	and	and	CC
cord-023439-r04y1j22	196	28	may	may	MD
cord-023439-r04y1j22	196	29	therefore	therefore	RB
cord-023439-r04y1j22	196	30	not	not	RB
cord-023439-r04y1j22	196	31	protect	protect	VB
cord-023439-r04y1j22	196	32	against	against	IN
cord-023439-r04y1j22	196	33	pulmonary	pulmonary	JJ
cord-023439-r04y1j22	196	34	TB	tb	NN
cord-023439-r04y1j22	196	35	.	.	.
cord-023439-r04y1j22	197	1	A	a	DT
cord-023439-r04y1j22	197	2	decrease	decrease	NN
cord-023439-r04y1j22	197	3	in	in	IN
cord-023439-r04y1j22	197	4	TB	TB	NNP
cord-023439-r04y1j22	197	5	mortality	mortality	NN
cord-023439-r04y1j22	197	6	may	may	MD
cord-023439-r04y1j22	197	7	be	be	VB
cord-023439-r04y1j22	197	8	achieved	achieve	VBN
cord-023439-r04y1j22	197	9	by	by	IN
cord-023439-r04y1j22	197	10	enhancing	enhance	VBG
cord-023439-r04y1j22	197	11	immunity	immunity	NN
cord-023439-r04y1j22	197	12	in	in	IN
cord-023439-r04y1j22	197	13	the	the	DT
cord-023439-r04y1j22	197	14	lung	lung	NN
cord-023439-r04y1j22	197	15	.	.	.
cord-023439-r04y1j22	198	1	The	the	DT
cord-023439-r04y1j22	198	2	present	present	JJ
cord-023439-r04y1j22	198	3	study	study	NN
cord-023439-r04y1j22	198	4	evaluated	evaluate	VBD
cord-023439-r04y1j22	198	5	the	the	DT
cord-023439-r04y1j22	198	6	induction	induction	NN
cord-023439-r04y1j22	198	7	of	of	IN
cord-023439-r04y1j22	198	8	antigen	antigen	NN
cord-023439-r04y1j22	198	9	-	-	HYPH
cord-023439-r04y1j22	198	10	specific	specific	JJ
cord-023439-r04y1j22	198	11	immunity	immunity	NN
cord-023439-r04y1j22	198	12	in	in	IN
cord-023439-r04y1j22	198	13	the	the	DT
cord-023439-r04y1j22	198	14	lung	lung	NN
cord-023439-r04y1j22	198	15	by	by	IN
cord-023439-r04y1j22	198	16	intranasal	intranasal	NN
cord-023439-r04y1j22	198	17	(	(	-LRB-
cord-023439-r04y1j22	198	18	i.n	i.n	NNP
cord-023439-r04y1j22	198	19	.	.	NNP
cord-023439-r04y1j22	198	20	)	)	-RRB-
cord-023439-r04y1j22	198	21	delivery	delivery	NN
cord-023439-r04y1j22	198	22	of	of	IN
cord-023439-r04y1j22	198	23	the	the	DT
cord-023439-r04y1j22	198	24	lipoprotein	lipoprotein	NN
cord-023439-r04y1j22	199	1	I	-PRON-	PRP
cord-023439-r04y1j22	199	2	(	(	-LRB-
cord-023439-r04y1j22	199	3	OprI	OprI	NNP
cord-023439-r04y1j22	199	4	)	)	-RRB-
cord-023439-r04y1j22	199	5	from	from	IN
cord-023439-r04y1j22	199	6	Pseudomonas	Pseudomonas	NNP
cord-023439-r04y1j22	199	7	aeruginosa	aeruginosa	NN
cord-023439-r04y1j22	199	8	.	.	.
cord-023439-r04y1j22	200	1	OprI	OprI	NNP
cord-023439-r04y1j22	200	2	has	have	VBZ
cord-023439-r04y1j22	200	3	shown	show	VBN
cord-023439-r04y1j22	200	4	to	to	TO
cord-023439-r04y1j22	200	5	be	be	VB
cord-023439-r04y1j22	200	6	a	a	DT
cord-023439-r04y1j22	200	7	Toll	toll	NN
cord-023439-r04y1j22	200	8	-	-	HYPH
cord-023439-r04y1j22	200	9	like	like	JJ
cord-023439-r04y1j22	200	10	receptor	receptor	NN
cord-023439-r04y1j22	200	11	2/4	2/4	CD
cord-023439-r04y1j22	200	12	agonist	agonist	NN
cord-023439-r04y1j22	200	13	that	that	WDT
cord-023439-r04y1j22	200	14	,	,	,
cord-023439-r04y1j22	200	15	when	when	WRB
cord-023439-r04y1j22	200	16	given	give	VBN
cord-023439-r04y1j22	200	17	subcutaneously	subcutaneously	RB
cord-023439-r04y1j22	200	18	,	,	,
cord-023439-r04y1j22	200	19	induces	induce	VBZ
cord-023439-r04y1j22	200	20	Type-1	type-1	NN
cord-023439-r04y1j22	200	21	immune	immune	JJ
cord-023439-r04y1j22	200	22	responses	response	NNS
cord-023439-r04y1j22	200	23	against	against	IN
cord-023439-r04y1j22	200	24	heterologous	heterologous	JJ
cord-023439-r04y1j22	200	25	antigens	antigen	NNS
cord-023439-r04y1j22	200	26	.	.	.
cord-023439-r04y1j22	201	1	Here	here	RB
cord-023439-r04y1j22	201	2	,	,	,
cord-023439-r04y1j22	201	3	a	a	DT
cord-023439-r04y1j22	201	4	fusion	fusion	NN
cord-023439-r04y1j22	201	5	of	of	IN
cord-023439-r04y1j22	201	6	OprI	OprI	NNP
cord-023439-r04y1j22	201	7	to	to	TO
cord-023439-r04y1j22	201	8	Ag85A	Ag85A	NNP
cord-023439-r04y1j22	201	9	of	of	IN
cord-023439-r04y1j22	201	10	Mtb	Mtb	NNP
cord-023439-r04y1j22	201	11	(	(	-LRB-
cord-023439-r04y1j22	201	12	OprI	OprI	NNP
cord-023439-r04y1j22	201	13	-	-	HYPH
cord-023439-r04y1j22	201	14	Ag85A	Ag85A	NNP
cord-023439-r04y1j22	201	15	)	)	-RRB-
cord-023439-r04y1j22	201	16	was	be	VBD
cord-023439-r04y1j22	201	17	used	use	VBN
cord-023439-r04y1j22	201	18	as	as	IN
cord-023439-r04y1j22	201	19	a	a	DT
cord-023439-r04y1j22	201	20	subunit	subunit	NN
cord-023439-r04y1j22	201	21	vaccine	vaccine	NN
cord-023439-r04y1j22	201	22	in	in	IN
cord-023439-r04y1j22	201	23	homologous	homologous	JJ
cord-023439-r04y1j22	201	24	prime	prime	JJ
cord-023439-r04y1j22	201	25	-	-	HYPH
cord-023439-r04y1j22	201	26	boost	boost	NN
cord-023439-r04y1j22	201	27	immunizations	immunization	NNS
cord-023439-r04y1j22	201	28	.	.	.
cord-023439-r04y1j22	202	1	In	in	IN
cord-023439-r04y1j22	202	2	addition	addition	NN
cord-023439-r04y1j22	202	3	,	,	,
cord-023439-r04y1j22	202	4	OprI	OprI	NNP
cord-023439-r04y1j22	202	5	-	-	HYPH
cord-023439-r04y1j22	202	6	Ag85A	Ag85A	NNP
cord-023439-r04y1j22	202	7	was	be	VBD
cord-023439-r04y1j22	202	8	combined	combine	VBN
cord-023439-r04y1j22	202	9	with	with	IN
cord-023439-r04y1j22	202	10	an	an	DT
cord-023439-r04y1j22	202	11	Ag85A	ag85a	NN
cord-023439-r04y1j22	202	12	-	-	HYPH
cord-023439-r04y1j22	202	13	encoding	encode	VBG
cord-023439-r04y1j22	202	14	DNA	dna	NN
cord-023439-r04y1j22	202	15	vaccine	vaccine	NN
cord-023439-r04y1j22	202	16	(	(	-LRB-
cord-023439-r04y1j22	202	17	Ag85A	Ag85A	NNP
cord-023439-r04y1j22	202	18	DNA	DNA	NNP
cord-023439-r04y1j22	202	19	)	)	-RRB-
cord-023439-r04y1j22	202	20	or	or	CC
cord-023439-r04y1j22	202	21	with	with	IN
cord-023439-r04y1j22	202	22	BCG	BCG	NNP
cord-023439-r04y1j22	202	23	in	in	IN
cord-023439-r04y1j22	202	24	heterologous	heterologous	JJ
cord-023439-r04y1j22	202	25	prime	prime	JJ
cord-023439-r04y1j22	202	26	-	-	HYPH
cord-023439-r04y1j22	202	27	boost	boost	NN
cord-023439-r04y1j22	202	28	vaccinations	vaccination	NNS
cord-023439-r04y1j22	202	29	.	.	.
cord-023439-r04y1j22	203	1	Intranasal	intranasal	NN
cord-023439-r04y1j22	203	2	and	and	CC
cord-023439-r04y1j22	203	3	parenteral	parenteral	JJ
cord-023439-r04y1j22	203	4	delivery	delivery	NN
cord-023439-r04y1j22	203	5	with	with	IN
cord-023439-r04y1j22	203	6	OprI	OprI	NNP
cord-023439-r04y1j22	203	7	-	-	HYPH
cord-023439-r04y1j22	203	8	Ag85A	Ag85A	NNP
cord-023439-r04y1j22	203	9	elicited	elicit	VBD
cord-023439-r04y1j22	203	10	comparable	comparable	JJ
cord-023439-r04y1j22	203	11	T	t	NN
cord-023439-r04y1j22	203	12	-	-	HYPH
cord-023439-r04y1j22	203	13	cell	cell	NN
cord-023439-r04y1j22	203	14	responses	response	NNS
cord-023439-r04y1j22	203	15	in	in	IN
cord-023439-r04y1j22	203	16	the	the	DT
cord-023439-r04y1j22	203	17	spleen	spleen	NN
cord-023439-r04y1j22	203	18	;	;	:
cord-023439-r04y1j22	203	19	in	in	IN
cord-023439-r04y1j22	203	20	addition	addition	NN
cord-023439-r04y1j22	203	21	,	,	,
cord-023439-r04y1j22	203	22	i.n	i.n	NNP
cord-023439-r04y1j22	203	23	.	.	NNP
cord-023439-r04y1j22	203	24	delivery	delivery	NN
cord-023439-r04y1j22	203	25	elicited	elicit	VBD
cord-023439-r04y1j22	203	26	specific	specific	JJ
cord-023439-r04y1j22	203	27	T	t	NN
cord-023439-r04y1j22	203	28	-	-	HYPH
cord-023439-r04y1j22	203	29	cell	cell	NN
cord-023439-r04y1j22	203	30	responses	response	NNS
cord-023439-r04y1j22	203	31	in	in	IN
cord-023439-r04y1j22	203	32	the	the	DT
cord-023439-r04y1j22	203	33	lung	lung	NN
cord-023439-r04y1j22	203	34	lymph	lymph	NN
cord-023439-r04y1j22	203	35	nodes	node	NNS
cord-023439-r04y1j22	203	36	(	(	-LRB-
cord-023439-r04y1j22	203	37	LLNs	lln	NNS
cord-023439-r04y1j22	203	38	)	)	-RRB-
cord-023439-r04y1j22	203	39	.	.	.
cord-023439-r04y1j22	204	1	Intramuscular	intramuscular	JJ
cord-023439-r04y1j22	204	2	delivery	delivery	NN
cord-023439-r04y1j22	204	3	of	of	IN
cord-023439-r04y1j22	204	4	Ag85A	Ag85A	NNP
cord-023439-r04y1j22	204	5	DNA	DNA	NNP
cord-023439-r04y1j22	204	6	induced	induce	VBD
cord-023439-r04y1j22	204	7	significant	significant	JJ
cord-023439-r04y1j22	204	8	systemic	systemic	JJ
cord-023439-r04y1j22	204	9	Th1	th1	CD
cord-023439-r04y1j22	204	10	immune	immune	JJ
cord-023439-r04y1j22	204	11	responses	response	NNS
cord-023439-r04y1j22	204	12	.	.	.
cord-023439-r04y1j22	205	1	Intranasal	intranasal	NN
cord-023439-r04y1j22	205	2	boosting	boost	VBG
cord-023439-r04y1j22	205	3	with	with	IN
cord-023439-r04y1j22	205	4	OprI	OprI	NNP
cord-023439-r04y1j22	205	5	-	-	HYPH
cord-023439-r04y1j22	205	6	Ag85A	Ag85A	NNP
cord-023439-r04y1j22	205	7	enhanced	enhance	VBD
cord-023439-r04y1j22	205	8	this	this	DT
cord-023439-r04y1j22	205	9	response	response	NN
cord-023439-r04y1j22	205	10	and	and	CC
cord-023439-r04y1j22	205	11	in	in	IN
cord-023439-r04y1j22	205	12	addition	addition	NN
cord-023439-r04y1j22	205	13	induced	induce	VBD
cord-023439-r04y1j22	205	14	an	an	DT
cord-023439-r04y1j22	205	15	antigen	antigen	NN
cord-023439-r04y1j22	205	16	-	-	HYPH
cord-023439-r04y1j22	205	17	specific	specific	JJ
cord-023439-r04y1j22	205	18	IFN	IFN	NNP
cord-023439-r04y1j22	205	19	-	-	HYPH
cord-023439-r04y1j22	205	20	g	g	NN
cord-023439-r04y1j22	205	21	response	response	NN
cord-023439-r04y1j22	205	22	in	in	IN
cord-023439-r04y1j22	205	23	LLN	LLN	NNP
cord-023439-r04y1j22	205	24	.	.	.
cord-023439-r04y1j22	206	1	OprI	OprI	NNP
cord-023439-r04y1j22	206	2	may	may	MD
cord-023439-r04y1j22	206	3	therefore	therefore	RB
cord-023439-r04y1j22	206	4	be	be	VB
cord-023439-r04y1j22	206	5	an	an	DT
cord-023439-r04y1j22	206	6	efficient	efficient	JJ
cord-023439-r04y1j22	206	7	adjuvant	adjuvant	NN
cord-023439-r04y1j22	206	8	for	for	IN
cord-023439-r04y1j22	206	9	mucosal	mucosal	JJ
cord-023439-r04y1j22	206	10	boosting	boosting	NN
cord-023439-r04y1j22	206	11	.	.	.
cord-023439-r04y1j22	207	1	We	-PRON-	PRP
cord-023439-r04y1j22	207	2	continue	continue	VBP
cord-023439-r04y1j22	207	3	to	to	TO
cord-023439-r04y1j22	207	4	evaluate	evaluate	VB
cord-023439-r04y1j22	207	5	the	the	DT
cord-023439-r04y1j22	207	6	protection	protection	NN
cord-023439-r04y1j22	207	7	induced	induce	VBN
cord-023439-r04y1j22	207	8	by	by	IN
cord-023439-r04y1j22	207	9	OprI	OprI	NNP
cord-023439-r04y1j22	207	10	-	-	HYPH
cord-023439-r04y1j22	207	11	based	base	VBN
cord-023439-r04y1j22	207	12	prime	prime	JJ
cord-023439-r04y1j22	207	13	-	-	HYPH
cord-023439-r04y1j22	207	14	boost	boost	NN
cord-023439-r04y1j22	207	15	vaccinations	vaccination	NNS
cord-023439-r04y1j22	207	16	against	against	IN
cord-023439-r04y1j22	207	17	pulmonary	pulmonary	JJ
cord-023439-r04y1j22	207	18	TB	TB	NNP
cord-023439-r04y1j22	207	19	.	.	.
cord-023439-r04y1j22	208	1	Results	result	NNS
cord-023439-r04y1j22	208	2	on	on	IN
cord-023439-r04y1j22	208	3	the	the	DT
cord-023439-r04y1j22	208	4	immunogenicity	immunogenicity	NN
cord-023439-r04y1j22	208	5	and	and	CC
cord-023439-r04y1j22	208	6	protection	protection	NN
cord-023439-r04y1j22	208	7	against	against	IN
cord-023439-r04y1j22	208	8	intravenous	intravenous	JJ
cord-023439-r04y1j22	208	9	Mtb	Mtb	NNP
cord-023439-r04y1j22	208	10	H37Rv	H37Rv	NNP
cord-023439-r04y1j22	208	11	infection	infection	NN
cord-023439-r04y1j22	208	12	will	will	MD
cord-023439-r04y1j22	208	13	be	be	VB
cord-023439-r04y1j22	208	14	presented	present	VBN
cord-023439-r04y1j22	208	15	.	.	.
cord-023439-r04y1j22	209	1	Toll	toll	NN
cord-023439-r04y1j22	209	2	-	-	HYPH
cord-023439-r04y1j22	209	3	like	like	JJ
cord-023439-r04y1j22	209	4	receptors	receptor	NNS
cord-023439-r04y1j22	209	5	(	(	-LRB-
cord-023439-r04y1j22	209	6	TLRs	TLRs	NNP
cord-023439-r04y1j22	209	7	)	)	-RRB-
cord-023439-r04y1j22	209	8	are	be	VBP
cord-023439-r04y1j22	209	9	pattern	pattern	NN
cord-023439-r04y1j22	209	10	recognition	recognition	NN
cord-023439-r04y1j22	209	11	receptors	receptor	NNS
cord-023439-r04y1j22	209	12	of	of	IN
cord-023439-r04y1j22	209	13	the	the	DT
cord-023439-r04y1j22	209	14	innate	innate	JJ
cord-023439-r04y1j22	209	15	immune	immune	JJ
cord-023439-r04y1j22	209	16	system	system	NN
cord-023439-r04y1j22	209	17	,	,	,
cord-023439-r04y1j22	209	18	which	which	WDT
cord-023439-r04y1j22	209	19	recognize	recognize	VBP
cord-023439-r04y1j22	209	20	molecular	molecular	JJ
cord-023439-r04y1j22	209	21	structures	structure	NNS
cord-023439-r04y1j22	209	22	on	on	IN
cord-023439-r04y1j22	209	23	pathogens	pathogen	NNS
cord-023439-r04y1j22	209	24	or	or	CC
cord-023439-r04y1j22	209	25	cellular	cellular	JJ
cord-023439-r04y1j22	209	26	stress	stress	NN
cord-023439-r04y1j22	209	27	-	-	HYPH
cord-023439-r04y1j22	209	28	associated	associate	VBN
cord-023439-r04y1j22	209	29	molecules	molecule	NNS
cord-023439-r04y1j22	209	30	.	.	.
cord-023439-r04y1j22	210	1	TLR	TLR	NNP
cord-023439-r04y1j22	210	2	-	-	HYPH
cord-023439-r04y1j22	210	3	ligand	ligand	NN
cord-023439-r04y1j22	210	4	interactions	interaction	NNS
cord-023439-r04y1j22	210	5	trigger	trigger	VBP
cord-023439-r04y1j22	210	6	activation	activation	NN
cord-023439-r04y1j22	210	7	of	of	IN
cord-023439-r04y1j22	210	8	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	210	9	signal	signal	NN
cord-023439-r04y1j22	210	10	transduction	transduction	NN
cord-023439-r04y1j22	210	11	and	and	CC
cord-023439-r04y1j22	210	12	expression	expression	NN
cord-023439-r04y1j22	210	13	of	of	IN
cord-023439-r04y1j22	210	14	genes	gene	NNS
cord-023439-r04y1j22	210	15	involved	involve	VBN
cord-023439-r04y1j22	210	16	in	in	IN
cord-023439-r04y1j22	210	17	host	host	NN
cord-023439-r04y1j22	210	18	defense	defense	NN
cord-023439-r04y1j22	210	19	.	.	.
cord-023439-r04y1j22	211	1	In	in	IN
cord-023439-r04y1j22	211	2	this	this	DT
cord-023439-r04y1j22	211	3	study	study	NN
cord-023439-r04y1j22	211	4	,	,	,
cord-023439-r04y1j22	211	5	we	-PRON-	PRP
cord-023439-r04y1j22	211	6	have	have	VBP
cord-023439-r04y1j22	211	7	examined	examine	VBN
cord-023439-r04y1j22	211	8	the	the	DT
cord-023439-r04y1j22	211	9	requirement	requirement	NN
cord-023439-r04y1j22	211	10	for	for	IN
cord-023439-r04y1j22	211	11	different	different	JJ
cord-023439-r04y1j22	211	12	TLR	TLR	NNP
cord-023439-r04y1j22	211	13	adaptor	adaptor	NN
cord-023439-r04y1j22	211	14	molecules	molecule	NNS
cord-023439-r04y1j22	211	15	in	in	IN
cord-023439-r04y1j22	211	16	virus	virus	NN
cord-023439-r04y1j22	211	17	-	-	HYPH
cord-023439-r04y1j22	211	18	induced	induce	VBN
cord-023439-r04y1j22	211	19	chemokine	chemokine	NN
cord-023439-r04y1j22	211	20	expression	expression	NN
cord-023439-r04y1j22	211	21	and	and	CC
cord-023439-r04y1j22	211	22	are	be	VBP
cord-023439-r04y1j22	211	23	currently	currently	RB
cord-023439-r04y1j22	211	24	trying	try	VBG
cord-023439-r04y1j22	211	25	to	to	TO
cord-023439-r04y1j22	211	26	identify	identify	VB
cord-023439-r04y1j22	211	27	the	the	DT
cord-023439-r04y1j22	211	28	TLR	TLR	NNP
cord-023439-r04y1j22	211	29	involved	involve	VBN
cord-023439-r04y1j22	211	30	.	.	.
cord-023439-r04y1j22	212	1	We	-PRON-	PRP
cord-023439-r04y1j22	212	2	have	have	VBP
cord-023439-r04y1j22	212	3	found	find	VBN
cord-023439-r04y1j22	212	4	that	that	IN
cord-023439-r04y1j22	212	5	both	both	CC
cord-023439-r04y1j22	212	6	a	a	DT
cord-023439-r04y1j22	212	7	herpesvirus	herpesvirus	NN
cord-023439-r04y1j22	212	8	[	[	-LRB-
cord-023439-r04y1j22	212	9	herpes	herpes	NN
cord-023439-r04y1j22	212	10	simplex	simplex	NN
cord-023439-r04y1j22	212	11	virus	virus	NN
cord-023439-r04y1j22	212	12	(	(	-LRB-
cord-023439-r04y1j22	212	13	HSV	HSV	NNP
cord-023439-r04y1j22	212	14	)	)	-RRB-
cord-023439-r04y1j22	212	15	]	]	-RRB-
cord-023439-r04y1j22	212	16	and	and	CC
cord-023439-r04y1j22	212	17	a	a	DT
cord-023439-r04y1j22	212	18	paramyxovirus	paramyxovirus	JJ
cord-023439-r04y1j22	212	19	(	(	-LRB-
cord-023439-r04y1j22	212	20	Sendai	Sendai	NNP
cord-023439-r04y1j22	212	21	virus	virus	NN
cord-023439-r04y1j22	212	22	)	)	-RRB-
cord-023439-r04y1j22	212	23	require	require	VBP
cord-023439-r04y1j22	212	24	a	a	DT
cord-023439-r04y1j22	212	25	functional	functional	JJ
cord-023439-r04y1j22	212	26	genome	genome	NN
cord-023439-r04y1j22	212	27	to	to	TO
cord-023439-r04y1j22	212	28	induce	induce	VB
cord-023439-r04y1j22	212	29	expression	expression	NN
cord-023439-r04y1j22	212	30	or	or	CC
cord-023439-r04y1j22	212	31	proinflammatory	proinflammatory	JJ
cord-023439-r04y1j22	212	32	chemokines	chemokine	NNS
cord-023439-r04y1j22	212	33	in	in	IN
cord-023439-r04y1j22	212	34	human	human	JJ
cord-023439-r04y1j22	212	35	and	and	CC
cord-023439-r04y1j22	212	36	murine	murine	JJ
cord-023439-r04y1j22	212	37	monocytic	monocytic	JJ
cord-023439-r04y1j22	212	38	cell	cell	NN
cord-023439-r04y1j22	212	39	lines	line	NNS
cord-023439-r04y1j22	212	40	.	.	.
cord-023439-r04y1j22	213	1	For	for	IN
cord-023439-r04y1j22	213	2	both	both	DT
cord-023439-r04y1j22	213	3	viruses	virus	NNS
cord-023439-r04y1j22	213	4	,	,	,
cord-023439-r04y1j22	213	5	this	this	DT
cord-023439-r04y1j22	213	6	is	be	VBZ
cord-023439-r04y1j22	213	7	independent	independent	JJ
cord-023439-r04y1j22	213	8	of	of	IN
cord-023439-r04y1j22	213	9	the	the	DT
cord-023439-r04y1j22	213	10	TLR	TLR	NNP
cord-023439-r04y1j22	213	11	adaptor	adaptor	NN
cord-023439-r04y1j22	213	12	molecules	molecule	NNS
cord-023439-r04y1j22	214	1	TRIF	TRIF	NNP
cord-023439-r04y1j22	214	2	and	and	CC
cord-023439-r04y1j22	214	3	Mal	Mal	NNP
cord-023439-r04y1j22	214	4	.	.	.
cord-023439-r04y1j22	215	1	However	however	RB
cord-023439-r04y1j22	215	2	,	,	,
cord-023439-r04y1j22	215	3	overexpression	overexpression	NN
cord-023439-r04y1j22	215	4	of	of	IN
cord-023439-r04y1j22	215	5	the	the	DT
cord-023439-r04y1j22	215	6	Vaccinia	Vaccinia	NNP
cord-023439-r04y1j22	215	7	virus	virus	NN
cord-023439-r04y1j22	215	8	-	-	HYPH
cord-023439-r04y1j22	215	9	encoded	encode	VBN
cord-023439-r04y1j22	215	10	inhibitor	inhibitor	NN
cord-023439-r04y1j22	215	11	of	of	IN
cord-023439-r04y1j22	215	12	TLR	TLR	NNP
cord-023439-r04y1j22	215	13	-	-	HYPH
cord-023439-r04y1j22	215	14	signalling	signal	VBG
cord-023439-r04y1j22	215	15	A52R	a52r	NN
cord-023439-r04y1j22	215	16	or	or	CC
cord-023439-r04y1j22	215	17	dominant	dominant	JJ
cord-023439-r04y1j22	215	18	-	-	HYPH
cord-023439-r04y1j22	215	19	negative	negative	JJ
cord-023439-r04y1j22	215	20	MyD88	MyD88	NNS
cord-023439-r04y1j22	215	21	totally	totally	RB
cord-023439-r04y1j22	215	22	inhibited	inhibited	JJ
cord-023439-r04y1j22	215	23	HSV	HSV	NNP
cord-023439-r04y1j22	215	24	-	-	HYPH
cord-023439-r04y1j22	215	25	induced	induce	VBN
cord-023439-r04y1j22	215	26	RANTES	RANTES	NNP
cord-023439-r04y1j22	215	27	expression	expression	NN
cord-023439-r04y1j22	215	28	but	but	CC
cord-023439-r04y1j22	215	29	only	only	RB
cord-023439-r04y1j22	215	30	partially	partially	RB
cord-023439-r04y1j22	215	31	prevented	prevent	VBD
cord-023439-r04y1j22	215	32	Sendai	Sendai	NNP
cord-023439-r04y1j22	215	33	virus	virus	NN
cord-023439-r04y1j22	215	34	from	from	IN
cord-023439-r04y1j22	215	35	inducing	induce	VBG
cord-023439-r04y1j22	215	36	this	this	DT
cord-023439-r04y1j22	215	37	chemokine	chemokine	NN
cord-023439-r04y1j22	215	38	.	.	.
cord-023439-r04y1j22	216	1	This	this	DT
cord-023439-r04y1j22	216	2	suggests	suggest	VBZ
cord-023439-r04y1j22	216	3	that	that	IN
cord-023439-r04y1j22	216	4	HSV	HSV	NNP
cord-023439-r04y1j22	216	5	-	-	HYPH
cord-023439-r04y1j22	216	6	induced	induce	VBN
cord-023439-r04y1j22	216	7	RANTES	RANTES	NNP
cord-023439-r04y1j22	216	8	expression	expression	NN
cord-023439-r04y1j22	216	9	occurs	occur	VBZ
cord-023439-r04y1j22	216	10	via	via	IN
cord-023439-r04y1j22	216	11	a	a	DT
cord-023439-r04y1j22	216	12	TLR	TLR	NNP
cord-023439-r04y1j22	216	13	pathways	pathway	NNS
cord-023439-r04y1j22	216	14	,	,	,
cord-023439-r04y1j22	216	15	whereas	whereas	IN
cord-023439-r04y1j22	216	16	Sendai	Sendai	NNP
cord-023439-r04y1j22	216	17	virus	virus	NN
cord-023439-r04y1j22	216	18	utilizes	utilize	VBZ
cord-023439-r04y1j22	216	19	both	both	DT
cord-023439-r04y1j22	216	20	TLR	TLR	NNP
cord-023439-r04y1j22	216	21	-	-	HYPH
cord-023439-r04y1j22	216	22	dependent	dependent	JJ
cord-023439-r04y1j22	216	23	and	and	CC
cord-023439-r04y1j22	216	24	-independent	-independent	JJ
cord-023439-r04y1j22	216	25	pathways	pathway	NNS
cord-023439-r04y1j22	216	26	to	to	TO
cord-023439-r04y1j22	216	27	stimulate	stimulate	VB
cord-023439-r04y1j22	216	28	expression	expression	NN
cord-023439-r04y1j22	216	29	of	of	IN
cord-023439-r04y1j22	216	30	RANTES	rante	NNS
cord-023439-r04y1j22	216	31	.	.	.
cord-023439-r04y1j22	217	1	We	-PRON-	PRP
cord-023439-r04y1j22	217	2	are	be	VBP
cord-023439-r04y1j22	217	3	currently	currently	RB
cord-023439-r04y1j22	217	4	trying	try	VBG
cord-023439-r04y1j22	217	5	to	to	TO
cord-023439-r04y1j22	217	6	identify	identify	VB
cord-023439-r04y1j22	217	7	the	the	DT
cord-023439-r04y1j22	217	8	TLRs	tlr	NNS
cord-023439-r04y1j22	217	9	involved	involve	VBN
cord-023439-r04y1j22	217	10	.	.	.
cord-023439-r04y1j22	218	1	Data	datum	NNS
cord-023439-r04y1j22	218	2	from	from	IN
cord-023439-r04y1j22	218	3	these	these	DT
cord-023439-r04y1j22	218	4	studies	study	NNS
cord-023439-r04y1j22	218	5	will	will	MD
cord-023439-r04y1j22	218	6	also	also	RB
cord-023439-r04y1j22	218	7	be	be	VB
cord-023439-r04y1j22	218	8	presented	present	VBN
cord-023439-r04y1j22	218	9	at	at	IN
cord-023439-r04y1j22	218	10	the	the	DT
cord-023439-r04y1j22	218	11	meeting	meeting	NN
cord-023439-r04y1j22	218	12	.	.	.
cord-023439-r04y1j22	219	1	2	2	LS
cord-023439-r04y1j22	219	2	0	0	CD
cord-023439-r04y1j22	219	3	-5	-5	CD
cord-023439-r04y1j22	219	4	0	0	CD
cord-023439-r04y1j22	220	1	-oligoadenylate	-oligoadenylate	.
cord-023439-r04y1j22	221	1	synthetases	synthetase	NNS
cord-023439-r04y1j22	221	2	are	be	VBP
cord-023439-r04y1j22	221	3	interferon	interferon	NN
cord-023439-r04y1j22	221	4	-	-	HYPH
cord-023439-r04y1j22	221	5	induced	induce	VBN
cord-023439-r04y1j22	221	6	,	,	,
cord-023439-r04y1j22	221	7	double	double	RB
cord-023439-r04y1j22	221	8	-	-	HYPH
cord-023439-r04y1j22	221	9	stranded	strand	VBN
cord-023439-r04y1j22	221	10	RNA	RNA	NNP
cord-023439-r04y1j22	221	11	-	-	HYPH
cord-023439-r04y1j22	221	12	activated	activate	VBN
cord-023439-r04y1j22	221	13	antiviral	antiviral	JJ
cord-023439-r04y1j22	221	14	enzymes	enzyme	NNS
cord-023439-r04y1j22	221	15	which	which	WDT
cord-023439-r04y1j22	221	16	are	be	VBP
cord-023439-r04y1j22	221	17	the	the	DT
cord-023439-r04y1j22	221	18	only	only	JJ
cord-023439-r04y1j22	221	19	proteins	protein	NNS
cord-023439-r04y1j22	221	20	known	know	VBN
cord-023439-r04y1j22	221	21	to	to	TO
cord-023439-r04y1j22	221	22	catalyse	catalyse	VB
cord-023439-r04y1j22	221	23	2	2	CD
cord-023439-r04y1j22	221	24	0	0	CD
cord-023439-r04y1j22	221	25	-specific	-specific	NN
cord-023439-r04y1j22	221	26	nucleotidyl	nucleotidyl	NN
cord-023439-r04y1j22	221	27	transfer	transfer	NN
cord-023439-r04y1j22	221	28	.	.	.
cord-023439-r04y1j22	222	1	This	this	DT
cord-023439-r04y1j22	222	2	first	first	JJ
cord-023439-r04y1j22	222	3	crystal	crystal	NN
cord-023439-r04y1j22	222	4	structure	structure	NN
cord-023439-r04y1j22	222	5	of	of	IN
cord-023439-r04y1j22	222	6	a	a	DT
cord-023439-r04y1j22	222	7	2	2	CD
cord-023439-r04y1j22	222	8	0	0	CD
cord-023439-r04y1j22	222	9	-5	-5	CD
cord-023439-r04y1j22	222	10	0oligoadenylate	0oligoadenylate	CD
cord-023439-r04y1j22	222	11	synthetase	synthetase	NNP
cord-023439-r04y1j22	222	12	reveals	reveal	VBZ
cord-023439-r04y1j22	222	13	a	a	DT
cord-023439-r04y1j22	222	14	structural	structural	JJ
cord-023439-r04y1j22	222	15	conservation	conservation	NN
cord-023439-r04y1j22	222	16	with	with	IN
cord-023439-r04y1j22	222	17	the	the	DT
cord-023439-r04y1j22	222	18	3	3	CD
cord-023439-r04y1j22	222	19	0	0	CD
cord-023439-r04y1j22	222	20	-specific	-specific	NN
cord-023439-r04y1j22	222	21	poly(A	poly(A	NNP
cord-023439-r04y1j22	222	22	)	)	-RRB-
cord-023439-r04y1j22	222	23	polymerase	polymerase	NN
cord-023439-r04y1j22	222	24	that	that	WDT
cord-023439-r04y1j22	222	25	,	,	,
cord-023439-r04y1j22	222	26	coupled	couple	VBN
cord-023439-r04y1j22	222	27	with	with	IN
cord-023439-r04y1j22	222	28	structure	structure	NN
cord-023439-r04y1j22	222	29	-	-	HYPH
cord-023439-r04y1j22	222	30	guided	guide	VBN
cord-023439-r04y1j22	222	31	mutagenesis	mutagenesis	NN
cord-023439-r04y1j22	222	32	,	,	,
cord-023439-r04y1j22	222	33	supports	support	VBZ
cord-023439-r04y1j22	222	34	a	a	DT
cord-023439-r04y1j22	222	35	conserved	conserved	JJ
cord-023439-r04y1j22	222	36	catalytic	catalytic	JJ
cord-023439-r04y1j22	222	37	mechanism	mechanism	NN
cord-023439-r04y1j22	222	38	for	for	IN
cord-023439-r04y1j22	222	39	the	the	DT
cord-023439-r04y1j22	222	40	2	2	CD
cord-023439-r04y1j22	222	41	0	0	CD
cord-023439-r04y1j22	222	42	-and	-and	SYM
cord-023439-r04y1j22	222	43	3	3	CD
cord-023439-r04y1j22	222	44	0	0	CD
cord-023439-r04y1j22	222	45	-specific	-specific	HYPH
cord-023439-r04y1j22	222	46	nucleotidyl	nucleotidyl	NN
cord-023439-r04y1j22	222	47	transferases	transferase	NNS
cord-023439-r04y1j22	222	48	.	.	.
cord-023439-r04y1j22	223	1	Comparison	comparison	NN
cord-023439-r04y1j22	223	2	with	with	IN
cord-023439-r04y1j22	223	3	structures	structure	NNS
cord-023439-r04y1j22	223	4	of	of	IN
cord-023439-r04y1j22	223	5	other	other	JJ
cord-023439-r04y1j22	223	6	superfamily	superfamily	NN
cord-023439-r04y1j22	223	7	members	member	NNS
cord-023439-r04y1j22	223	8	indicates	indicate	VBZ
cord-023439-r04y1j22	223	9	that	that	IN
cord-023439-r04y1j22	223	10	the	the	DT
cord-023439-r04y1j22	223	11	donor	donor	NN
cord-023439-r04y1j22	223	12	substrates	substrate	NNS
cord-023439-r04y1j22	223	13	are	be	VBP
cord-023439-r04y1j22	223	14	bound	bind	VBN
cord-023439-r04y1j22	223	15	by	by	IN
cord-023439-r04y1j22	223	16	conserved	conserve	VBN
cord-023439-r04y1j22	223	17	active	active	JJ
cord-023439-r04y1j22	223	18	site	site	NN
cord-023439-r04y1j22	223	19	features	feature	NNS
cord-023439-r04y1j22	223	20	while	while	IN
cord-023439-r04y1j22	223	21	the	the	DT
cord-023439-r04y1j22	223	22	acceptor	acceptor	NN
cord-023439-r04y1j22	223	23	substrates	substrate	NNS
cord-023439-r04y1j22	223	24	are	be	VBP
cord-023439-r04y1j22	223	25	oriented	orient	VBN
cord-023439-r04y1j22	223	26	by	by	IN
cord-023439-r04y1j22	223	27	nonconserved	nonconserved	JJ
cord-023439-r04y1j22	223	28	regions	region	NNS
cord-023439-r04y1j22	223	29	.	.	.
cord-023439-r04y1j22	224	1	The	the	DT
cord-023439-r04y1j22	224	2	2	2	CD
cord-023439-r04y1j22	224	3	0	0	CD
cord-023439-r04y1j22	224	4	-5	-5	NNP
cord-023439-r04y1j22	224	5	0oligoadenylate	0oligoadenylate	CD
cord-023439-r04y1j22	224	6	synthetases	synthetase	NNS
cord-023439-r04y1j22	224	7	are	be	VBP
cord-023439-r04y1j22	224	8	activated	activate	VBN
cord-023439-r04y1j22	224	9	by	by	IN
cord-023439-r04y1j22	224	10	viral	viral	JJ
cord-023439-r04y1j22	224	11	doublestranded	doublestranded	NNP
cord-023439-r04y1j22	224	12	RNA	RNA	NNP
cord-023439-r04y1j22	224	13	in	in	IN
cord-023439-r04y1j22	224	14	infected	infected	JJ
cord-023439-r04y1j22	224	15	cells	cell	NNS
cord-023439-r04y1j22	224	16	and	and	CC
cord-023439-r04y1j22	224	17	initiate	initiate	VB
cord-023439-r04y1j22	224	18	a	a	DT
cord-023439-r04y1j22	224	19	cellular	cellular	JJ
cord-023439-r04y1j22	224	20	response	response	NN
cord-023439-r04y1j22	224	21	by	by	IN
cord-023439-r04y1j22	224	22	synthesizing	synthesize	VBG
cord-023439-r04y1j22	224	23	2	2	CD
cord-023439-r04y1j22	224	24	0	0	CD
cord-023439-r04y1j22	224	25	-5	-5	CD
cord-023439-r04y1j22	224	26	0	0	CD
cord-023439-r04y1j22	224	27	-oligoadenylates	-oligoadenylate	NNS
cord-023439-r04y1j22	224	28	,	,	,
cord-023439-r04y1j22	224	29	that	that	IN
cord-023439-r04y1j22	224	30	in	in	IN
cord-023439-r04y1j22	224	31	turn	turn	NN
cord-023439-r04y1j22	224	32	activate	activate	VBP
cord-023439-r04y1j22	224	33	RNase	RNase	NNP
cord-023439-r04y1j22	224	34	L.	L.	NNP
cord-023439-r04y1j22	225	1	This	this	DT
cord-023439-r04y1j22	225	2	crystal	crystal	NN
cord-023439-r04y1j22	225	3	structure	structure	NN
cord-023439-r04y1j22	225	4	suggests	suggest	VBZ
cord-023439-r04y1j22	225	5	that	that	IN
cord-023439-r04y1j22	225	6	activation	activation	NN
cord-023439-r04y1j22	225	7	involves	involve	VBZ
cord-023439-r04y1j22	225	8	a	a	DT
cord-023439-r04y1j22	225	9	domain	domain	NN
cord-023439-r04y1j22	225	10	-	-	HYPH
cord-023439-r04y1j22	225	11	domain	domain	NN
cord-023439-r04y1j22	225	12	shift	shift	NN
cord-023439-r04y1j22	225	13	and	and	CC
cord-023439-r04y1j22	225	14	identifies	identify	VBZ
cord-023439-r04y1j22	225	15	a	a	DT
cord-023439-r04y1j22	225	16	putative	putative	JJ
cord-023439-r04y1j22	225	17	dsRNA	dsrna	NN
cord-023439-r04y1j22	225	18	activation	activation	NN
cord-023439-r04y1j22	225	19	site	site	NN
cord-023439-r04y1j22	225	20	that	that	WDT
cord-023439-r04y1j22	225	21	is	be	VBZ
cord-023439-r04y1j22	225	22	probed	probe	VBN
cord-023439-r04y1j22	225	23	by	by	IN
cord-023439-r04y1j22	225	24	mutagenesis	mutagenesis	NN
cord-023439-r04y1j22	225	25	.	.	.
cord-023439-r04y1j22	226	1	We	-PRON-	PRP
cord-023439-r04y1j22	226	2	demonstrated	demonstrate	VBD
cord-023439-r04y1j22	226	3	that	that	IN
cord-023439-r04y1j22	226	4	this	this	DT
cord-023439-r04y1j22	226	5	site	site	NN
cord-023439-r04y1j22	226	6	is	be	VBZ
cord-023439-r04y1j22	226	7	required	require	VBN
cord-023439-r04y1j22	226	8	both	both	CC
cord-023439-r04y1j22	226	9	for	for	IN
cord-023439-r04y1j22	226	10	the	the	DT
cord-023439-r04y1j22	226	11	binding	binding	NN
cord-023439-r04y1j22	226	12	of	of	IN
cord-023439-r04y1j22	226	13	dsRNA	dsrna	NN
cord-023439-r04y1j22	226	14	and	and	CC
cord-023439-r04y1j22	226	15	for	for	IN
cord-023439-r04y1j22	226	16	the	the	DT
cord-023439-r04y1j22	226	17	subsequent	subsequent	JJ
cord-023439-r04y1j22	226	18	activation	activation	NN
cord-023439-r04y1j22	226	19	of	of	IN
cord-023439-r04y1j22	226	20	OAS	OAS	NNP
cord-023439-r04y1j22	226	21	.	.	.
cord-023439-r04y1j22	227	1	This	this	DT
cord-023439-r04y1j22	227	2	RNA	rna	NN
cord-023439-r04y1j22	227	3	-	-	HYPH
cord-023439-r04y1j22	227	4	binding	bind	VBG
cord-023439-r04y1j22	227	5	site	site	NN
cord-023439-r04y1j22	227	6	is	be	VBZ
cord-023439-r04y1j22	227	7	different	different	JJ
cord-023439-r04y1j22	227	8	from	from	IN
cord-023439-r04y1j22	227	9	known	know	VBN
cord-023439-r04y1j22	227	10	RNA	rna	NN
cord-023439-r04y1j22	227	11	-	-	HYPH
cord-023439-r04y1j22	227	12	binding	bind	VBG
cord-023439-r04y1j22	227	13	site	site	NN
cord-023439-r04y1j22	227	14	;	;	:
cord-023439-r04y1j22	227	15	rather	rather	RB
cord-023439-r04y1j22	227	16	than	than	IN
cord-023439-r04y1j22	227	17	forming	form	VBG
cord-023439-r04y1j22	227	18	a	a	DT
cord-023439-r04y1j22	227	19	defined	define	VBN
cord-023439-r04y1j22	227	20	three	three	CD
cord-023439-r04y1j22	227	21	-	-	HYPH
cord-023439-r04y1j22	227	22	dimensional	dimensional	JJ
cord-023439-r04y1j22	227	23	domain	domain	NN
cord-023439-r04y1j22	227	24	,	,	,
cord-023439-r04y1j22	227	25	it	-PRON-	PRP
cord-023439-r04y1j22	227	26	is	be	VBZ
cord-023439-r04y1j22	227	27	located	locate	VBN
cord-023439-r04y1j22	227	28	at	at	IN
cord-023439-r04y1j22	227	29	the	the	DT
cord-023439-r04y1j22	227	30	interface	interface	NN
cord-023439-r04y1j22	227	31	of	of	IN
cord-023439-r04y1j22	227	32	the	the	DT
cord-023439-r04y1j22	227	33	two	two	CD
cord-023439-r04y1j22	227	34	major	major	JJ
cord-023439-r04y1j22	227	35	domains	domain	NNS
cord-023439-r04y1j22	227	36	in	in	IN
cord-023439-r04y1j22	227	37	OAS	OAS	NNP
cord-023439-r04y1j22	227	38	.	.	.
cord-023439-r04y1j22	228	1	This	this	DT
cord-023439-r04y1j22	228	2	novel	novel	NN
cord-023439-r04y1j22	228	3	architecture	architecture	NN
cord-023439-r04y1j22	228	4	ensures	ensure	VBZ
cord-023439-r04y1j22	228	5	that	that	IN
cord-023439-r04y1j22	228	6	the	the	DT
cord-023439-r04y1j22	228	7	dsRNA	dsrna	NN
cord-023439-r04y1j22	228	8	helix	helix	NN
cord-023439-r04y1j22	228	9	can	can	MD
cord-023439-r04y1j22	228	10	make	make	VB
cord-023439-r04y1j22	228	11	simultaneously	simultaneously	RB
cord-023439-r04y1j22	228	12	contact	contact	VB
cord-023439-r04y1j22	228	13	with	with	IN
cord-023439-r04y1j22	228	14	both	both	DT
cord-023439-r04y1j22	228	15	domains	domain	NNS
cord-023439-r04y1j22	228	16	of	of	IN
cord-023439-r04y1j22	228	17	OAS	OAS	NNP
cord-023439-r04y1j22	228	18	and	and	CC
cord-023439-r04y1j22	228	19	ensure	ensure	VB
cord-023439-r04y1j22	228	20	the	the	DT
cord-023439-r04y1j22	228	21	subsequent	subsequent	JJ
cord-023439-r04y1j22	228	22	structural	structural	JJ
cord-023439-r04y1j22	228	23	rearrangement	rearrangement	NN
cord-023439-r04y1j22	228	24	leading	lead	VBG
cord-023439-r04y1j22	228	25	to	to	IN
cord-023439-r04y1j22	228	26	the	the	DT
cord-023439-r04y1j22	228	27	activation	activation	NN
cord-023439-r04y1j22	228	28	of	of	IN
cord-023439-r04y1j22	228	29	OAS	OAS	NNP
cord-023439-r04y1j22	228	30	.	.	.
cord-023439-r04y1j22	229	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	229	2	work	work	NN
cord-023439-r04y1j22	229	3	provides	provide	VBZ
cord-023439-r04y1j22	229	4	structural	structural	JJ
cord-023439-r04y1j22	229	5	insight	insight	NN
cord-023439-r04y1j22	229	6	into	into	IN
cord-023439-r04y1j22	229	7	cellular	cellular	JJ
cord-023439-r04y1j22	229	8	recognition	recognition	NN
cord-023439-r04y1j22	229	9	of	of	IN
cord-023439-r04y1j22	229	10	double	double	RB
cord-023439-r04y1j22	229	11	-	-	HYPH
cord-023439-r04y1j22	229	12	stranded	strand	VBN
cord-023439-r04y1j22	229	13	RNA	RNA	NNP
cord-023439-r04y1j22	229	14	of	of	IN
cord-023439-r04y1j22	229	15	viral	viral	JJ
cord-023439-r04y1j22	229	16	origin	origin	NN
cord-023439-r04y1j22	229	17	and	and	CC
cord-023439-r04y1j22	229	18	identifies	identify	VBZ
cord-023439-r04y1j22	229	19	a	a	DT
cord-023439-r04y1j22	229	20	novel	novel	JJ
cord-023439-r04y1j22	229	21	RNA	rna	NN
cord-023439-r04y1j22	229	22	-	-	HYPH
cord-023439-r04y1j22	229	23	binding	bind	VBG
cord-023439-r04y1j22	229	24	motif	motif	NN
cord-023439-r04y1j22	229	25	.	.	.
cord-023439-r04y1j22	230	1	Bacteria	Bacteria	NNS
cord-023439-r04y1j22	230	2	-	-	HYPH
cord-023439-r04y1j22	230	3	specific	specific	JJ
cord-023439-r04y1j22	230	4	IgA	IgA	NNP
cord-023439-r04y1j22	230	5	antibodies	antibody	NNS
cord-023439-r04y1j22	230	6	are	be	VBP
cord-023439-r04y1j22	230	7	efficient	efficient	JJ
cord-023439-r04y1j22	230	8	opsonins	opsonin	NNS
cord-023439-r04y1j22	230	9	for	for	IN
cord-023439-r04y1j22	230	10	neutrophils	neutrophil	NNS
cord-023439-r04y1j22	230	11	and	and	CC
cord-023439-r04y1j22	230	12	mononuclear	mononuclear	JJ
cord-023439-r04y1j22	230	13	phagocytes	phagocyte	NNS
cord-023439-r04y1j22	230	14	,	,	,
cord-023439-r04y1j22	230	15	provided	provide	VBD
cord-023439-r04y1j22	230	16	that	that	IN
cord-023439-r04y1j22	230	17	the	the	DT
cord-023439-r04y1j22	230	18	phagocytes	phagocyte	NNS
cord-023439-r04y1j22	230	19	express	express	VBP
cord-023439-r04y1j22	230	20	the	the	DT
cord-023439-r04y1j22	230	21	Fca	Fca	NNP
cord-023439-r04y1j22	230	22	receptor	receptor	NN
cord-023439-r04y1j22	230	23	(	(	-LRB-
cord-023439-r04y1j22	230	24	CD89	CD89	NNP
cord-023439-r04y1j22	230	25	)	)	-RRB-
cord-023439-r04y1j22	230	26	.	.	.
cord-023439-r04y1j22	231	1	Expression	expression	NN
cord-023439-r04y1j22	231	2	of	of	IN
cord-023439-r04y1j22	231	3	CD89	CD89	NNP
cord-023439-r04y1j22	231	4	can	can	MD
cord-023439-r04y1j22	231	5	be	be	VB
cord-023439-r04y1j22	231	6	stimulated	stimulate	VBN
cord-023439-r04y1j22	231	7	by	by	IN
cord-023439-r04y1j22	231	8	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	231	9	cytokines	cytokine	NNS
cord-023439-r04y1j22	231	10	,	,	,
cord-023439-r04y1j22	231	11	activated	activate	VBN
cord-023439-r04y1j22	231	12	complement	complement	NN
cord-023439-r04y1j22	231	13	factors	factor	NNS
cord-023439-r04y1j22	231	14	and	and	CC
cord-023439-r04y1j22	231	15	certain	certain	JJ
cord-023439-r04y1j22	231	16	microbial	microbial	JJ
cord-023439-r04y1j22	231	17	components	component	NNS
cord-023439-r04y1j22	231	18	.	.	.
cord-023439-r04y1j22	232	1	In	in	IN
cord-023439-r04y1j22	232	2	one	one	CD
cord-023439-r04y1j22	232	3	study	study	NN
cord-023439-r04y1j22	232	4	,	,	,
cord-023439-r04y1j22	232	5	unstimulated	unstimulated	JJ
cord-023439-r04y1j22	232	6	phagocytes	phagocyte	NNS
cord-023439-r04y1j22	232	7	were	be	VBD
cord-023439-r04y1j22	232	8	able	able	JJ
cord-023439-r04y1j22	232	9	to	to	TO
cord-023439-r04y1j22	232	10	ingest	ingest	VB
cord-023439-r04y1j22	232	11	IgA	IgA	NNP
cord-023439-r04y1j22	232	12	antibody	antibody	NN
cord-023439-r04y1j22	232	13	-	-	HYPH
cord-023439-r04y1j22	232	14	treated	treat	VBN
cord-023439-r04y1j22	232	15	pneumococci	pneumococci	NN
cord-023439-r04y1j22	232	16	,	,	,
cord-023439-r04y1j22	232	17	but	but	CC
cord-023439-r04y1j22	232	18	only	only	RB
cord-023439-r04y1j22	232	19	in	in	IN
cord-023439-r04y1j22	232	20	the	the	DT
cord-023439-r04y1j22	232	21	presence	presence	NN
cord-023439-r04y1j22	232	22	of	of	IN
cord-023439-r04y1j22	232	23	complement	complement	NN
cord-023439-r04y1j22	232	24	,	,	,
cord-023439-r04y1j22	232	25	which	which	WDT
cord-023439-r04y1j22	232	26	was	be	VBD
cord-023439-r04y1j22	232	27	found	find	VBN
cord-023439-r04y1j22	232	28	to	to	TO
cord-023439-r04y1j22	232	29	be	be	VB
cord-023439-r04y1j22	232	30	activated	activate	VBN
cord-023439-r04y1j22	232	31	by	by	IN
cord-023439-r04y1j22	232	32	the	the	DT
cord-023439-r04y1j22	232	33	IgA	IgA	NNP
cord-023439-r04y1j22	232	34	antibodies	antibody	NNS
cord-023439-r04y1j22	232	35	along	along	IN
cord-023439-r04y1j22	232	36	the	the	DT
cord-023439-r04y1j22	232	37	alternative	alternative	JJ
cord-023439-r04y1j22	232	38	pathway	pathway	NN
cord-023439-r04y1j22	232	39	.	.	.
cord-023439-r04y1j22	233	1	Pneumococci	pneumococcus	NNS
cord-023439-r04y1j22	233	2	produce	produce	VBP
cord-023439-r04y1j22	233	3	IgA1	iga1	PRP
cord-023439-r04y1j22	233	4	protease	protease	NN
cord-023439-r04y1j22	233	5	that	that	WDT
cord-023439-r04y1j22	233	6	cleaves	cleave	VBZ
cord-023439-r04y1j22	233	7	human	human	JJ
cord-023439-r04y1j22	233	8	IgA1	IgA1	NNP
cord-023439-r04y1j22	233	9	,	,	,
cord-023439-r04y1j22	233	10	but	but	CC
cord-023439-r04y1j22	233	11	not	not	RB
cord-023439-r04y1j22	233	12	IgA2	IgA2	VBN
cord-023439-r04y1j22	233	13	,	,	,
cord-023439-r04y1j22	233	14	molecules	molecule	NNS
cord-023439-r04y1j22	233	15	in	in	IN
cord-023439-r04y1j22	233	16	the	the	DT
cord-023439-r04y1j22	233	17	hinge	hinge	NN
cord-023439-r04y1j22	233	18	region	region	NN
cord-023439-r04y1j22	233	19	.	.	.
cord-023439-r04y1j22	234	1	This	this	DT
cord-023439-r04y1j22	234	2	leaves	leave	VBZ
cord-023439-r04y1j22	234	3	IgA1	iga1	PRP
cord-023439-r04y1j22	234	4	as	as	IN
cord-023439-r04y1j22	234	5	Faba	Faba	NNP
cord-023439-r04y1j22	234	6	(	(	-LRB-
cord-023439-r04y1j22	234	7	monovalent	monovalent	NN
cord-023439-r04y1j22	234	8	)	)	-RRB-
cord-023439-r04y1j22	234	9	deprived	deprive	VBN
cord-023439-r04y1j22	234	10	of	of	IN
cord-023439-r04y1j22	234	11	Fca	Fca	NNP
cord-023439-r04y1j22	234	12	which	which	WDT
cord-023439-r04y1j22	234	13	contains	contain	VBZ
cord-023439-r04y1j22	234	14	the	the	DT
cord-023439-r04y1j22	234	15	docking	docking	NN
cord-023439-r04y1j22	234	16	site	site	NN
cord-023439-r04y1j22	234	17	for	for	IN
cord-023439-r04y1j22	234	18	CD89	CD89	NNP
cord-023439-r04y1j22	234	19	.	.	.
cord-023439-r04y1j22	235	1	IgA1	iga1	UH
cord-023439-r04y1j22	235	2	is	be	VBZ
cord-023439-r04y1j22	235	3	the	the	DT
cord-023439-r04y1j22	235	4	vastly	vastly	RB
cord-023439-r04y1j22	235	5	predominant	predominant	JJ
cord-023439-r04y1j22	235	6	subclass	subclass	NN
cord-023439-r04y1j22	235	7	of	of	IN
cord-023439-r04y1j22	235	8	IgA	IgA	NNP
cord-023439-r04y1j22	235	9	in	in	IN
cord-023439-r04y1j22	235	10	the	the	DT
cord-023439-r04y1j22	235	11	upper	upper	NNP
cord-023439-r04y1j22	235	12	airways	airway	NNS
cord-023439-r04y1j22	235	13	and	and	CC
cord-023439-r04y1j22	235	14	circulation	circulation	NN
cord-023439-r04y1j22	235	15	of	of	IN
cord-023439-r04y1j22	235	16	humans	human	NNS
cord-023439-r04y1j22	235	17	.	.	.
cord-023439-r04y1j22	236	1	Aims	aim	VBZ
cord-023439-r04y1j22	236	2	:	:	:
cord-023439-r04y1j22	237	1	To	to	TO
cord-023439-r04y1j22	237	2	examine	examine	VB
cord-023439-r04y1j22	237	3	the	the	DT
cord-023439-r04y1j22	237	4	effects	effect	NNS
cord-023439-r04y1j22	237	5	of	of	IN
cord-023439-r04y1j22	237	6	IgA1	iga1	CD
cord-023439-r04y1j22	237	7	protease	protease	NN
cord-023439-r04y1j22	237	8	activity	activity	NN
cord-023439-r04y1j22	237	9	and	and	CC
cord-023439-r04y1j22	237	10	complement	complement	VB
cord-023439-r04y1j22	237	11	on	on	IN
cord-023439-r04y1j22	237	12	phagocytosis	phagocytosis	NN
cord-023439-r04y1j22	237	13	of	of	IN
cord-023439-r04y1j22	237	14	IgA	IgA	NNP
cord-023439-r04y1j22	237	15	antibody	antibody	NN
cord-023439-r04y1j22	237	16	-	-	HYPH
cord-023439-r04y1j22	237	17	coated	coat	VBN
cord-023439-r04y1j22	237	18	pneumococci	pneumococcus	NNS
cord-023439-r04y1j22	237	19	by	by	IN
cord-023439-r04y1j22	237	20	an	an	DT
cord-023439-r04y1j22	237	21	unstimulated	unstimulated	JJ
cord-023439-r04y1j22	237	22	human	human	JJ
cord-023439-r04y1j22	237	23	phagocytic	phagocytic	JJ
cord-023439-r04y1j22	237	24	cell	cell	NN
cord-023439-r04y1j22	237	25	line	line	NN
cord-023439-r04y1j22	237	26	(	(	-LRB-
cord-023439-r04y1j22	237	27	hl60	hl60	NNP
cord-023439-r04y1j22	237	28	)	)	-RRB-
cord-023439-r04y1j22	237	29	.	.	.
cord-023439-r04y1j22	238	1	Materials	material	NNS
cord-023439-r04y1j22	238	2	and	and	CC
cord-023439-r04y1j22	238	3	methods	method	NNS
cord-023439-r04y1j22	238	4	:	:	:
cord-023439-r04y1j22	238	5	IgA1	iga1	ADD
cord-023439-r04y1j22	238	6	and	and	CC
cord-023439-r04y1j22	238	7	IgA2	IgA2	VBD
cord-023439-r04y1j22	238	8	monoclonal	monoclonal	JJ
cord-023439-r04y1j22	238	9	antibodies	antibody	NNS
cord-023439-r04y1j22	238	10	to	to	IN
cord-023439-r04y1j22	238	11	serotype	serotype	NN
cord-023439-r04y1j22	238	12	4	4	CD
cord-023439-r04y1j22	238	13	pneumococcal	pneumococcal	JJ
cord-023439-r04y1j22	238	14	capsular	capsular	NN
cord-023439-r04y1j22	238	15	polysaccharide	polysaccharide	NN
cord-023439-r04y1j22	238	16	(	(	-LRB-
cord-023439-r04y1j22	238	17	ps	ps	UH
cord-023439-r04y1j22	238	18	)	)	-RRB-
cord-023439-r04y1j22	238	19	were	be	VBD
cord-023439-r04y1j22	238	20	generated	generate	VBN
cord-023439-r04y1j22	238	21	by	by	IN
cord-023439-r04y1j22	238	22	heterohybridoma	heterohybridoma	NN
cord-023439-r04y1j22	238	23	technique	technique	NN
cord-023439-r04y1j22	238	24	involving	involve	VBG
cord-023439-r04y1j22	238	25	B	b	NN
cord-023439-r04y1j22	238	26	cells	cell	NNS
cord-023439-r04y1j22	238	27	from	from	IN
cord-023439-r04y1j22	238	28	human	human	JJ
cord-023439-r04y1j22	238	29	vaccinees	vaccinee	NNS
cord-023439-r04y1j22	238	30	.	.	.
cord-023439-r04y1j22	239	1	Isogenic	Isogenic	NNP
cord-023439-r04y1j22	239	2	serotype	serotype	NN
cord-023439-r04y1j22	239	3	4	4	CD
cord-023439-r04y1j22	239	4	pneumococci	pneumococcus	NNS
cord-023439-r04y1j22	239	5	with	with	IN
cord-023439-r04y1j22	239	6	and	and	CC
cord-023439-r04y1j22	239	7	without	without	IN
cord-023439-r04y1j22	239	8	IgA1	iga1	PRP$
cord-023439-r04y1j22	239	9	protease	protease	NN
cord-023439-r04y1j22	239	10	activity	activity	NN
cord-023439-r04y1j22	239	11	,	,	,
cord-023439-r04y1j22	239	12	respectively	respectively	RB
cord-023439-r04y1j22	239	13	,	,	,
cord-023439-r04y1j22	239	14	were	be	VBD
cord-023439-r04y1j22	239	15	obtained	obtain	VBN
cord-023439-r04y1j22	239	16	after	after	IN
cord-023439-r04y1j22	239	17	inactivation	inactivation	NN
cord-023439-r04y1j22	239	18	of	of	IN
cord-023439-r04y1j22	239	19	the	the	DT
cord-023439-r04y1j22	239	20	iga	iga	NNP
cord-023439-r04y1j22	239	21	gene	gene	NN
cord-023439-r04y1j22	239	22	of	of	IN
cord-023439-r04y1j22	239	23	the	the	DT
cord-023439-r04y1j22	239	24	TIGR4	TIGR4	NNP
cord-023439-r04y1j22	239	25	strain	strain	NN
cord-023439-r04y1j22	239	26	.	.	.
cord-023439-r04y1j22	240	1	Opsonophagocytosis	Opsonophagocytosis	NNP
cord-023439-r04y1j22	240	2	was	be	VBD
cord-023439-r04y1j22	240	3	quantitated	quantitate	VBN
cord-023439-r04y1j22	240	4	using	use	VBG
cord-023439-r04y1j22	240	5	the	the	DT
cord-023439-r04y1j22	240	6	assay	assay	NN
cord-023439-r04y1j22	240	7	described	describe	VBN
cord-023439-r04y1j22	240	8	by	by	IN
cord-023439-r04y1j22	240	9	Romero	Romero	NNP
cord-023439-r04y1j22	240	10	-	-	HYPH
cord-023439-r04y1j22	240	11	Steiner	Steiner	NNP
cord-023439-r04y1j22	240	12	et	et	NNP
cord-023439-r04y1j22	240	13	al	al	NNP
cord-023439-r04y1j22	240	14	.	.	.
cord-023439-r04y1j22	241	1	Based	base	VBN
cord-023439-r04y1j22	241	2	on	on	IN
cord-023439-r04y1j22	241	3	enumeration	enumeration	NN
cord-023439-r04y1j22	241	4	of	of	IN
cord-023439-r04y1j22	241	5	surviving	survive	VBG
cord-023439-r04y1j22	241	6	bacteria	bacteria	NNS
cord-023439-r04y1j22	241	7	by	by	IN
cord-023439-r04y1j22	241	8	culture	culture	NN
cord-023439-r04y1j22	241	9	.	.	.
cord-023439-r04y1j22	242	1	The	the	DT
cord-023439-r04y1j22	242	2	integrity	integrity	NN
cord-023439-r04y1j22	242	3	of	of	IN
cord-023439-r04y1j22	242	4	IgA	IgA	NNP
cord-023439-r04y1j22	242	5	molecules	molecule	NNS
cord-023439-r04y1j22	242	6	was	be	VBD
cord-023439-r04y1j22	242	7	examined	examine	VBN
cord-023439-r04y1j22	242	8	by	by	IN
cord-023439-r04y1j22	242	9	western	western	JJ
cord-023439-r04y1j22	242	10	blotting	blotting	NN
cord-023439-r04y1j22	242	11	.	.	.
cord-023439-r04y1j22	243	1	Results	result	NNS
cord-023439-r04y1j22	243	2	:	:	:
cord-023439-r04y1j22	244	1	Both	both	CC
cord-023439-r04y1j22	244	2	IgA1	iga1	PRP
cord-023439-r04y1j22	244	3	and	and	CC
cord-023439-r04y1j22	244	4	IgA2	IgA2	VBD
cord-023439-r04y1j22	244	5	antibody	antibody	NN
cord-023439-r04y1j22	244	6	to	to	IN
cord-023439-r04y1j22	244	7	type-4	type-4	NNP
cord-023439-r04y1j22	244	8	polysaccharide	polysaccharide	NN
cord-023439-r04y1j22	244	9	-	-	HYPH
cord-023439-r04y1j22	244	10	induced	induce	VBN
cord-023439-r04y1j22	244	11	phagocytosis	phagocytosis	NN
cord-023439-r04y1j22	244	12	of	of	IN
cord-023439-r04y1j22	244	13	IgA1	iga1	DT
cord-023439-r04y1j22	244	14	protease	protease	NN
cord-023439-r04y1j22	244	15	-	-	HYPH
cord-023439-r04y1j22	244	16	deficient	deficient	JJ
cord-023439-r04y1j22	245	1	type-4	type-4	NNP
cord-023439-r04y1j22	245	2	pneumococci	pneumococcus	NNS
cord-023439-r04y1j22	245	3	equally	equally	RB
cord-023439-r04y1j22	245	4	well	well	RB
cord-023439-r04y1j22	245	5	in	in	IN
cord-023439-r04y1j22	245	6	the	the	DT
cord-023439-r04y1j22	245	7	absence	absence	NN
cord-023439-r04y1j22	245	8	as	as	IN
cord-023439-r04y1j22	245	9	in	in	IN
cord-023439-r04y1j22	245	10	the	the	DT
cord-023439-r04y1j22	245	11	presence	presence	NN
cord-023439-r04y1j22	245	12	of	of	IN
cord-023439-r04y1j22	245	13	complement	complement	NN
cord-023439-r04y1j22	245	14	.	.	.
cord-023439-r04y1j22	246	1	Iga1	iga1	JJ
cord-023439-r04y1j22	246	2	antibody	antibody	NN
cord-023439-r04y1j22	246	3	to	to	IN
cord-023439-r04y1j22	246	4	type-4	type-4	NNP
cord-023439-r04y1j22	246	5	polysaccharide	polysaccharide	NN
cord-023439-r04y1j22	246	6	displayed	display	VBD
cord-023439-r04y1j22	246	7	a	a	DT
cord-023439-r04y1j22	246	8	fourfold	fourfold	JJ
cord-023439-r04y1j22	246	9	higher	high	JJR
cord-023439-r04y1j22	246	10	opsonophagocytosis	opsonophagocytosis	NN
cord-023439-r04y1j22	246	11	titer	titer	NN
cord-023439-r04y1j22	246	12	against	against	IN
cord-023439-r04y1j22	246	13	IgA1	iga1	XX
cord-023439-r04y1j22	246	14	protease	protease	NN
cord-023439-r04y1j22	246	15	deficient	deficient	JJ
cord-023439-r04y1j22	246	16	compared	compare	VBN
cord-023439-r04y1j22	246	17	to	to	IN
cord-023439-r04y1j22	246	18	homologous	homologous	JJ
cord-023439-r04y1j22	246	19	wildtype	wildtype	NN
cord-023439-r04y1j22	246	20	target	target	NN
cord-023439-r04y1j22	246	21	bacteria	bacteria	NNS
cord-023439-r04y1j22	246	22	.	.	.
cord-023439-r04y1j22	247	1	A	a	DT
cord-023439-r04y1j22	247	2	similar	similar	JJ
cord-023439-r04y1j22	247	3	effect	effect	NN
cord-023439-r04y1j22	247	4	of	of	IN
cord-023439-r04y1j22	247	5	IgA1	iga1	CD
cord-023439-r04y1j22	247	6	protease	protease	NN
cord-023439-r04y1j22	247	7	activity	activity	NN
cord-023439-r04y1j22	247	8	of	of	IN
cord-023439-r04y1j22	247	9	the	the	DT
cord-023439-r04y1j22	247	10	target	target	NN
cord-023439-r04y1j22	247	11	bacteria	bacteria	NNS
cord-023439-r04y1j22	247	12	was	be	VBD
cord-023439-r04y1j22	247	13	not	not	RB
cord-023439-r04y1j22	247	14	observed	observe	VBN
cord-023439-r04y1j22	247	15	in	in	IN
cord-023439-r04y1j22	247	16	a	a	DT
cord-023439-r04y1j22	247	17	parallel	parallel	JJ
cord-023439-r04y1j22	247	18	experiment	experiment	NN
cord-023439-r04y1j22	247	19	where	where	WRB
cord-023439-r04y1j22	247	20	IgA2	iga2	JJ
cord-023439-r04y1j22	247	21	antibody	antibody	NN
cord-023439-r04y1j22	247	22	to	to	IN
cord-023439-r04y1j22	247	23	type-4	type-4	NNP
cord-023439-r04y1j22	247	24	polysaccharide	polysaccharide	NN
cord-023439-r04y1j22	247	25	served	serve	VBD
cord-023439-r04y1j22	247	26	as	as	IN
cord-023439-r04y1j22	247	27	opsonin	opsonin	NNP
cord-023439-r04y1j22	247	28	.	.	.
cord-023439-r04y1j22	248	1	IgA1	iga1	DT
cord-023439-r04y1j22	248	2	antibody	antibody	NN
cord-023439-r04y1j22	248	3	extracted	extract	VBD
cord-023439-r04y1j22	248	4	from	from	IN
cord-023439-r04y1j22	248	5	IgA1	iga1	DT
cord-023439-r04y1j22	248	6	protease	protease	NN
cord-023439-r04y1j22	248	7	-	-	HYPH
cord-023439-r04y1j22	248	8	producing	produce	VBG
cord-023439-r04y1j22	248	9	target	target	NN
cord-023439-r04y1j22	248	10	bacteria	bacteria	NNS
cord-023439-r04y1j22	248	11	was	be	VBD
cord-023439-r04y1j22	248	12	almost	almost	RB
cord-023439-r04y1j22	248	13	exclusively	exclusively	RB
cord-023439-r04y1j22	248	14	in	in	IN
cord-023439-r04y1j22	248	15	the	the	DT
cord-023439-r04y1j22	248	16	form	form	NN
cord-023439-r04y1j22	248	17	of	of	IN
cord-023439-r04y1j22	248	18	Faba	Faba	NNP
cord-023439-r04y1j22	248	19	.	.	.
cord-023439-r04y1j22	249	1	Conversely	conversely	RB
cord-023439-r04y1j22	249	2	,	,	,
cord-023439-r04y1j22	249	3	IgA1	iga1	RB
cord-023439-r04y1j22	249	4	from	from	IN
cord-023439-r04y1j22	249	5	protease	protease	NN
cord-023439-r04y1j22	249	6	-	-	HYPH
cord-023439-r04y1j22	249	7	deficient	deficient	JJ
cord-023439-r04y1j22	249	8	bacteria	bacteria	NNS
cord-023439-r04y1j22	249	9	and	and	CC
cord-023439-r04y1j22	249	10	IgA2	iga2	NN
cord-023439-r04y1j22	249	11	from	from	IN
cord-023439-r04y1j22	249	12	both	both	DT
cord-023439-r04y1j22	249	13	types	type	NNS
cord-023439-r04y1j22	249	14	of	of	IN
cord-023439-r04y1j22	249	15	bacteria	bacteria	NNS
cord-023439-r04y1j22	249	16	were	be	VBD
cord-023439-r04y1j22	249	17	intact	intact	JJ
cord-023439-r04y1j22	249	18	.	.	.
cord-023439-r04y1j22	250	1	Conclusions	conclusion	NNS
cord-023439-r04y1j22	250	2	:	:	:
cord-023439-r04y1j22	251	1	These	these	DT
cord-023439-r04y1j22	251	2	results	result	NNS
cord-023439-r04y1j22	251	3	indicate	indicate	VBP
cord-023439-r04y1j22	251	4	that	that	IN
cord-023439-r04y1j22	251	5	the	the	DT
cord-023439-r04y1j22	251	6	IgA1	iga1	CD
cord-023439-r04y1j22	251	7	protease	protease	NN
cord-023439-r04y1j22	251	8	activity	activity	NN
cord-023439-r04y1j22	251	9	of	of	IN
cord-023439-r04y1j22	251	10	S.	S.	NNP
cord-023439-r04y1j22	251	11	neumoniae	neumoniae	NNS
cord-023439-r04y1j22	251	12	may	may	MD
cord-023439-r04y1j22	251	13	help	help	VB
cord-023439-r04y1j22	251	14	the	the	DT
cord-023439-r04y1j22	251	15	bacteria	bacteria	NNS
cord-023439-r04y1j22	251	16	escape	escape	VB
cord-023439-r04y1j22	251	17	IgA1	iga1	ADD
cord-023439-r04y1j22	251	18	antibody	antibody	NN
cord-023439-r04y1j22	251	19	-	-	HYPH
cord-023439-r04y1j22	251	20	mediated	mediate	VBN
cord-023439-r04y1j22	251	21	opsonophagocytosis	opsonophagocytosis	NN
cord-023439-r04y1j22	251	22	.	.	.
cord-023439-r04y1j22	252	1	Besides	besides	RB
cord-023439-r04y1j22	252	2	,	,	,
cord-023439-r04y1j22	252	3	in	in	IN
cord-023439-r04y1j22	252	4	these	these	DT
cord-023439-r04y1j22	252	5	experiments	experiment	NNS
cord-023439-r04y1j22	252	6	,	,	,
cord-023439-r04y1j22	252	7	IgA	IgA	NNP
cord-023439-r04y1j22	252	8	-	-	HYPH
cord-023439-r04y1j22	252	9	mediated	mediate	VBN
cord-023439-r04y1j22	252	10	opsonophagocytosis	opsonophagocytosis	NN
cord-023439-r04y1j22	252	11	was	be	VBD
cord-023439-r04y1j22	252	12	independent	independent	JJ
cord-023439-r04y1j22	252	13	of	of	IN
cord-023439-r04y1j22	252	14	complement	complement	NN
cord-023439-r04y1j22	252	15	.	.	.
cord-023439-r04y1j22	253	1	Vitamins	vitamin	NNS
cord-023439-r04y1j22	253	2	E	e	NN
cord-023439-r04y1j22	253	3	and	and	CC
cord-023439-r04y1j22	253	4	C	C	NNP
cord-023439-r04y1j22	253	5	have	have	VBP
cord-023439-r04y1j22	253	6	been	be	VBN
cord-023439-r04y1j22	253	7	found	find	VBN
cord-023439-r04y1j22	253	8	to	to	TO
cord-023439-r04y1j22	253	9	increase	increase	VB
cord-023439-r04y1j22	253	10	the	the	DT
cord-023439-r04y1j22	253	11	cellular	cellular	JJ
cord-023439-r04y1j22	253	12	and	and	CC
cord-023439-r04y1j22	253	13	humeral	humeral	JJ
cord-023439-r04y1j22	253	14	immunity	immunity	NN
cord-023439-r04y1j22	253	15	of	of	IN
cord-023439-r04y1j22	253	16	pigs	pig	NNS
cord-023439-r04y1j22	253	17	.	.	.
cord-023439-r04y1j22	254	1	Vitamin	vitamin	NN
cord-023439-r04y1j22	254	2	E	e	NN
cord-023439-r04y1j22	254	3	deficiency	deficiency	NN
cord-023439-r04y1j22	254	4	has	have	VBZ
cord-023439-r04y1j22	254	5	also	also	RB
cord-023439-r04y1j22	254	6	been	be	VBN
cord-023439-r04y1j22	254	7	found	find	VBN
cord-023439-r04y1j22	254	8	to	to	TO
cord-023439-r04y1j22	254	9	predispose	predispose	VB
cord-023439-r04y1j22	254	10	pigs	pig	NNS
cord-023439-r04y1j22	254	11	to	to	IN
cord-023439-r04y1j22	254	12	different	different	JJ
cord-023439-r04y1j22	254	13	diseases	disease	NNS
cord-023439-r04y1j22	254	14	,	,	,
cord-023439-r04y1j22	254	15	E.	E.	NNP
cord-023439-r04y1j22	254	16	coli	coli	VBZ
cord-023439-r04y1j22	254	17	infection	infection	NN
cord-023439-r04y1j22	254	18	is	be	VBZ
cord-023439-r04y1j22	254	19	one	one	CD
cord-023439-r04y1j22	254	20	among	among	IN
cord-023439-r04y1j22	254	21	them	-PRON-	PRP
cord-023439-r04y1j22	254	22	.	.	.
cord-023439-r04y1j22	255	1	After	after	IN
cord-023439-r04y1j22	255	2	weaning	wean	VBG
cord-023439-r04y1j22	255	3	,	,	,
cord-023439-r04y1j22	255	4	the	the	DT
cord-023439-r04y1j22	255	5	vitamin	vitamin	NN
cord-023439-r04y1j22	255	6	E	e	NN
cord-023439-r04y1j22	255	7	status	status	NN
cord-023439-r04y1j22	255	8	of	of	IN
cord-023439-r04y1j22	255	9	pigs	pig	NNS
cord-023439-r04y1j22	255	10	often	often	RB
cord-023439-r04y1j22	255	11	decreases	decrease	VBZ
cord-023439-r04y1j22	255	12	to	to	IN
cord-023439-r04y1j22	255	13	a	a	DT
cord-023439-r04y1j22	255	14	critical	critical	JJ
cord-023439-r04y1j22	255	15	low	low	JJ
cord-023439-r04y1j22	255	16	level	level	NN
cord-023439-r04y1j22	255	17	.	.	.
cord-023439-r04y1j22	256	1	In	in	IN
cord-023439-r04y1j22	256	2	this	this	DT
cord-023439-r04y1j22	256	3	experiment	experiment	NN
cord-023439-r04y1j22	256	4	,	,	,
cord-023439-r04y1j22	256	5	we	-PRON-	PRP
cord-023439-r04y1j22	256	6	studied	study	VBD
cord-023439-r04y1j22	256	7	whether	whether	IN
cord-023439-r04y1j22	256	8	vitamin	vitamin	NN
cord-023439-r04y1j22	256	9	C	c	NN
cord-023439-r04y1j22	256	10	supplementation	supplementation	NN
cord-023439-r04y1j22	256	11	would	would	MD
cord-023439-r04y1j22	256	12	be	be	VB
cord-023439-r04y1j22	256	13	a	a	DT
cord-023439-r04y1j22	256	14	possible	possible	JJ
cord-023439-r04y1j22	256	15	feeding	feeding	NN
cord-023439-r04y1j22	256	16	strategy	strategy	NN
cord-023439-r04y1j22	256	17	to	to	TO
cord-023439-r04y1j22	256	18	optimize	optimize	VB
cord-023439-r04y1j22	256	19	the	the	DT
cord-023439-r04y1j22	256	20	immune	immune	JJ
cord-023439-r04y1j22	256	21	status	status	NN
cord-023439-r04y1j22	256	22	of	of	IN
cord-023439-r04y1j22	256	23	weaners	weaner	NNS
cord-023439-r04y1j22	256	24	.	.	.
cord-023439-r04y1j22	257	1	The	the	DT
cord-023439-r04y1j22	257	2	interaction	interaction	NN
cord-023439-r04y1j22	257	3	between	between	IN
cord-023439-r04y1j22	257	4	vitamin	vitamin	NN
cord-023439-r04y1j22	257	5	E	e	NN
cord-023439-r04y1j22	257	6	and	and	CC
cord-023439-r04y1j22	257	7	C	C	NNP
cord-023439-r04y1j22	257	8	is	be	VBZ
cord-023439-r04y1j22	257	9	interesting	interesting	JJ
cord-023439-r04y1j22	257	10	due	due	IN
cord-023439-r04y1j22	257	11	to	to	IN
cord-023439-r04y1j22	257	12	the	the	DT
cord-023439-r04y1j22	257	13	reported	report	VBN
cord-023439-r04y1j22	257	14	sparing	spare	VBG
cord-023439-r04y1j22	257	15	action	action	NN
cord-023439-r04y1j22	257	16	on	on	IN
cord-023439-r04y1j22	257	17	vitamin	vitamin	NN
cord-023439-r04y1j22	257	18	E	e	NN
cord-023439-r04y1j22	257	19	or	or	CC
cord-023439-r04y1j22	257	20	synergism	synergism	NN
cord-023439-r04y1j22	257	21	between	between	IN
cord-023439-r04y1j22	257	22	these	these	DT
cord-023439-r04y1j22	257	23	to	to	IN
cord-023439-r04y1j22	257	24	vitamins	vitamin	NNS
cord-023439-r04y1j22	257	25	.	.	.
cord-023439-r04y1j22	258	1	Piglets	piglet	NNS
cord-023439-r04y1j22	258	2	were	be	VBD
cord-023439-r04y1j22	258	3	weaned	wean	VBN
cord-023439-r04y1j22	258	4	at	at	IN
cord-023439-r04y1j22	258	5	day	day	NN
cord-023439-r04y1j22	258	6	28	28	CD
cord-023439-r04y1j22	258	7	of	of	IN
cord-023439-r04y1j22	258	8	age	age	NN
cord-023439-r04y1j22	258	9	from	from	IN
cord-023439-r04y1j22	258	10	sows	sow	NNS
cord-023439-r04y1j22	258	11	fed	feed	VBD
cord-023439-r04y1j22	258	12	increasing	increase	VBG
cord-023439-r04y1j22	258	13	dietary	dietary	JJ
cord-023439-r04y1j22	258	14	vitamin	vitamin	NN
cord-023439-r04y1j22	258	15	E	e	NN
cord-023439-r04y1j22	258	16	during	during	IN
cord-023439-r04y1j22	258	17	lactation	lactation	NN
cord-023439-r04y1j22	258	18	,	,	,
cord-023439-r04y1j22	258	19	and	and	CC
cord-023439-r04y1j22	258	20	piglets	piglet	NNS
cord-023439-r04y1j22	258	21	were	be	VBD
cord-023439-r04y1j22	258	22	during	during	IN
cord-023439-r04y1j22	258	23	the	the	DT
cord-023439-r04y1j22	258	24	following	following	JJ
cord-023439-r04y1j22	258	25	3	3	CD
cord-023439-r04y1j22	258	26	weeks	week	NNS
cord-023439-r04y1j22	258	27	fed	feed	VBN
cord-023439-r04y1j22	258	28	either	either	CC
cord-023439-r04y1j22	258	29	a	a	DT
cord-023439-r04y1j22	258	30	control	control	NN
cord-023439-r04y1j22	258	31	diet	diet	NN
cord-023439-r04y1j22	258	32	or	or	CC
cord-023439-r04y1j22	258	33	this	this	DT
cord-023439-r04y1j22	258	34	diet	diet	NN
cord-023439-r04y1j22	258	35	supplemented	supplement	VBD
cord-023439-r04y1j22	258	36	with	with	IN
cord-023439-r04y1j22	258	37	500	500	CD
cord-023439-r04y1j22	258	38	mg	mg	NNP
cord-023439-r04y1j22	258	39	STAY	stay	NN
cord-023439-r04y1j22	258	40	-	-	HYPH
cord-023439-r04y1j22	258	41	C	C	NNP
cord-023439-r04y1j22	258	42	per	per	IN
cord-023439-r04y1j22	258	43	kg	kg	NN
cord-023439-r04y1j22	258	44	.	.	.
cord-023439-r04y1j22	259	1	Blood	blood	NN
cord-023439-r04y1j22	259	2	sampling	sampling	NN
cord-023439-r04y1j22	259	3	was	be	VBD
cord-023439-r04y1j22	259	4	obtained	obtain	VBN
cord-023439-r04y1j22	259	5	weekly	weekly	RB
cord-023439-r04y1j22	259	6	from	from	IN
cord-023439-r04y1j22	259	7	day	day	NN
cord-023439-r04y1j22	259	8	28	28	CD
cord-023439-r04y1j22	259	9	and	and	CC
cord-023439-r04y1j22	259	10	until	until	IN
cord-023439-r04y1j22	259	11	day	day	NN
cord-023439-r04y1j22	259	12	49	49	CD
cord-023439-r04y1j22	259	13	of	of	IN
cord-023439-r04y1j22	259	14	age	age	NN
cord-023439-r04y1j22	259	15	.	.	.
cord-023439-r04y1j22	260	1	On	on	IN
cord-023439-r04y1j22	260	2	the	the	DT
cord-023439-r04y1j22	260	3	same	same	JJ
cord-023439-r04y1j22	260	4	days	day	NNS
cord-023439-r04y1j22	260	5	,	,	,
cord-023439-r04y1j22	260	6	one	one	CD
cord-023439-r04y1j22	260	7	piglet	piglet	NN
cord-023439-r04y1j22	260	8	per	per	IN
cord-023439-r04y1j22	260	9	dietary	dietary	JJ
cord-023439-r04y1j22	260	10	treatment	treatment	NN
cord-023439-r04y1j22	260	11	was	be	VBD
cord-023439-r04y1j22	260	12	killed	kill	VBN
cord-023439-r04y1j22	260	13	and	and	CC
cord-023439-r04y1j22	260	14	alveolar	alveolar	NN
cord-023439-r04y1j22	260	15	macrophages	macrophage	NNS
cord-023439-r04y1j22	260	16	(	(	-LRB-
cord-023439-r04y1j22	260	17	AM	am	NN
cord-023439-r04y1j22	260	18	)	)	-RRB-
cord-023439-r04y1j22	260	19	were	be	VBD
cord-023439-r04y1j22	260	20	harvested	harvest	VBN
cord-023439-r04y1j22	260	21	.	.	.
cord-023439-r04y1j22	261	1	Vitamin	vitamin	NN
cord-023439-r04y1j22	261	2	C	c	NN
cord-023439-r04y1j22	261	3	supplementation	supplementation	NN
cord-023439-r04y1j22	261	4	increased	increase	VBD
cord-023439-r04y1j22	261	5	the	the	DT
cord-023439-r04y1j22	261	6	concentration	concentration	NN
cord-023439-r04y1j22	261	7	of	of	IN
cord-023439-r04y1j22	261	8	IgM	IgM	NNP
cord-023439-r04y1j22	261	9	in	in	IN
cord-023439-r04y1j22	261	10	serum	serum	NN
cord-023439-r04y1j22	261	11	of	of	IN
cord-023439-r04y1j22	261	12	piglets	piglet	NNS
cord-023439-r04y1j22	261	13	throughout	throughout	IN
cord-023439-r04y1j22	261	14	the	the	DT
cord-023439-r04y1j22	261	15	weaning	weaning	NN
cord-023439-r04y1j22	261	16	period	period	NN
cord-023439-r04y1j22	261	17	.	.	.
cord-023439-r04y1j22	262	1	Although	although	IN
cord-023439-r04y1j22	262	2	the	the	DT
cord-023439-r04y1j22	262	3	vitamin	vitamin	NN
cord-023439-r04y1j22	262	4	E	e	NN
cord-023439-r04y1j22	262	5	concentration	concentration	NN
cord-023439-r04y1j22	262	6	in	in	IN
cord-023439-r04y1j22	262	7	AM	AM	NNP
cord-023439-r04y1j22	262	8	decreased	decrease	VBD
cord-023439-r04y1j22	262	9	with	with	IN
cord-023439-r04y1j22	262	10	increasing	increase	VBG
cord-023439-r04y1j22	262	11	age	age	NN
cord-023439-r04y1j22	262	12	of	of	IN
cord-023439-r04y1j22	262	13	the	the	DT
cord-023439-r04y1j22	262	14	piglets	piglet	NNS
cord-023439-r04y1j22	262	15	,	,	,
cord-023439-r04y1j22	262	16	the	the	DT
cord-023439-r04y1j22	262	17	concentration	concentration	NN
cord-023439-r04y1j22	262	18	was	be	VBD
cord-023439-r04y1j22	262	19	numerically	numerically	RB
cord-023439-r04y1j22	262	20	higher	high	JJR
cord-023439-r04y1j22	262	21	in	in	IN
cord-023439-r04y1j22	262	22	piglets	piglet	NNS
cord-023439-r04y1j22	262	23	of	of	IN
cord-023439-r04y1j22	262	24	sows	sow	NNS
cord-023439-r04y1j22	262	25	fed	feed	VBD
cord-023439-r04y1j22	262	26	the	the	DT
cord-023439-r04y1j22	262	27	high	high	JJ
cord-023439-r04y1j22	262	28	dietary	dietary	JJ
cord-023439-r04y1j22	262	29	level	level	NN
cord-023439-r04y1j22	262	30	of	of	IN
cord-023439-r04y1j22	262	31	vitamin	vitamin	NN
cord-023439-r04y1j22	262	32	E.	E.	NNP
cord-023439-r04y1j22	263	1	However	however	RB
cord-023439-r04y1j22	263	2	,	,	,
cord-023439-r04y1j22	263	3	vitamin	vitamin	NN
cord-023439-r04y1j22	263	4	C	c	NN
cord-023439-r04y1j22	263	5	supplementation	supplementation	NN
cord-023439-r04y1j22	263	6	tended	tend	VBD
cord-023439-r04y1j22	263	7	to	to	TO
cord-023439-r04y1j22	263	8	increase	increase	VB
cord-023439-r04y1j22	263	9	the	the	DT
cord-023439-r04y1j22	263	10	total	total	JJ
cord-023439-r04y1j22	263	11	AM	AM	NNP
cord-023439-r04y1j22	263	12	concentration	concentration	NN
cord-023439-r04y1j22	263	13	of	of	IN
cord-023439-r04y1j22	263	14	vitamin	vitamin	NN
cord-023439-r04y1j22	263	15	E	e	NN
cord-023439-r04y1j22	263	16	after	after	IN
cord-023439-r04y1j22	263	17	weaning	weaning	NN
cord-023439-r04y1j22	263	18	and	and	CC
cord-023439-r04y1j22	263	19	increased	increase	VBD
cord-023439-r04y1j22	263	20	the	the	DT
cord-023439-r04y1j22	263	21	proportion	proportion	NN
cord-023439-r04y1j22	263	22	of	of	IN
cord-023439-r04y1j22	263	23	the	the	DT
cord-023439-r04y1j22	263	24	biologically	biologically	RB
cord-023439-r04y1j22	263	25	most	most	RBS
cord-023439-r04y1j22	263	26	active	active	JJ
cord-023439-r04y1j22	263	27	isomer	isomer	NN
cord-023439-r04y1j22	263	28	of	of	IN
cord-023439-r04y1j22	263	29	vitamin	vitamin	NN
cord-023439-r04y1j22	263	30	E	e	NN
cord-023439-r04y1j22	263	31	[	[	-LRB-
cord-023439-r04y1j22	263	32	RRR-(a	rrr-(a	NN
cord-023439-r04y1j22	263	33	-	-	HYPH
cord-023439-r04y1j22	263	34	tocopherol	tocopherol	NN
cord-023439-r04y1j22	263	35	)	)	-RRB-
cord-023439-r04y1j22	263	36	]	]	-RRB-
cord-023439-r04y1j22	263	37	in	in	IN
cord-023439-r04y1j22	263	38	the	the	DT
cord-023439-r04y1j22	263	39	AM	am	NN
cord-023439-r04y1j22	263	40	.	.	.
cord-023439-r04y1j22	264	1	The	the	DT
cord-023439-r04y1j22	264	2	eicosanoid	eicosanoid	JJ
cord-023439-r04y1j22	264	3	synthesis	synthesis	NN
cord-023439-r04y1j22	264	4	by	by	IN
cord-023439-r04y1j22	264	5	AM	AM	NNP
cord-023439-r04y1j22	264	6	was	be	VBD
cord-023439-r04y1j22	264	7	not	not	RB
cord-023439-r04y1j22	264	8	influenced	influence	VBN
cord-023439-r04y1j22	264	9	by	by	IN
cord-023439-r04y1j22	264	10	the	the	DT
cord-023439-r04y1j22	264	11	vitamin	vitamin	NN
cord-023439-r04y1j22	264	12	C	C	NNP
cord-023439-r04y1j22	264	13	supplementation	supplementation	NN
cord-023439-r04y1j22	264	14	,	,	,
cord-023439-r04y1j22	264	15	but	but	CC
cord-023439-r04y1j22	264	16	the	the	DT
cord-023439-r04y1j22	264	17	synthesis	synthesis	NN
cord-023439-r04y1j22	264	18	of	of	IN
cord-023439-r04y1j22	264	19	leukotriene	leukotriene	NN
cord-023439-r04y1j22	264	20	B4	B4	NNP
cord-023439-r04y1j22	264	21	was	be	VBD
cord-023439-r04y1j22	264	22	decreased	decrease	VBN
cord-023439-r04y1j22	264	23	2	2	CD
cord-023439-r04y1j22	264	24	weeks	week	NNS
cord-023439-r04y1j22	264	25	after	after	IN
cord-023439-r04y1j22	264	26	weaning	wean	VBG
cord-023439-r04y1j22	264	27	compared	compare	VBN
cord-023439-r04y1j22	264	28	to	to	IN
cord-023439-r04y1j22	264	29	other	other	JJ
cord-023439-r04y1j22	264	30	days	day	NNS
cord-023439-r04y1j22	264	31	of	of	IN
cord-023439-r04y1j22	264	32	AM	AM	NNP
cord-023439-r04y1j22	264	33	harvesting	harvest	VBG
cord-023439-r04y1j22	264	34	.	.	.
cord-023439-r04y1j22	265	1	In	in	IN
cord-023439-r04y1j22	265	2	conclusion	conclusion	NN
cord-023439-r04y1j22	265	3	,	,	,
cord-023439-r04y1j22	265	4	dietary	dietary	JJ
cord-023439-r04y1j22	265	5	vitamin	vitamin	NN
cord-023439-r04y1j22	265	6	C	C	NNP
cord-023439-r04y1j22	265	7	supplementation	supplementation	NN
cord-023439-r04y1j22	265	8	improved	improve	VBD
cord-023439-r04y1j22	265	9	the	the	DT
cord-023439-r04y1j22	265	10	immune	immune	JJ
cord-023439-r04y1j22	265	11	responses	response	NNS
cord-023439-r04y1j22	265	12	of	of	IN
cord-023439-r04y1j22	265	13	piglets	piglet	NNS
cord-023439-r04y1j22	265	14	after	after	IN
cord-023439-r04y1j22	265	15	weaning	wean	VBG
cord-023439-r04y1j22	265	16	.	.	.
cord-023439-r04y1j22	266	1	A	a	DT
cord-023439-r04y1j22	266	2	whole	whole	JJ
cord-023439-r04y1j22	266	3	blood	blood	NN
cord-023439-r04y1j22	266	4	stimulation	stimulation	NN
cord-023439-r04y1j22	266	5	assay	assay	NN
cord-023439-r04y1j22	266	6	with	with	IN
cord-023439-r04y1j22	266	7	Escherichia	Escherichia	NNP
cord-023439-r04y1j22	266	8	coli	coli	NNS
cord-023439-r04y1j22	266	9	(	(	-LRB-
cord-023439-r04y1j22	266	10	O111	O111	NNS
cord-023439-r04y1j22	266	11	:	:	:
cord-023439-r04y1j22	266	12	B4	B4	NNP
cord-023439-r04y1j22	266	13	)	)	-RRB-
cord-023439-r04y1j22	266	14	endotoxin	endotoxin	NN
cord-023439-r04y1j22	266	15	was	be	VBD
cord-023439-r04y1j22	266	16	established	establish	VBN
cord-023439-r04y1j22	266	17	to	to	TO
cord-023439-r04y1j22	266	18	measure	measure	VB
cord-023439-r04y1j22	266	19	the	the	DT
cord-023439-r04y1j22	266	20	capacity	capacity	NN
cord-023439-r04y1j22	266	21	of	of	IN
cord-023439-r04y1j22	266	22	dairy	dairy	NN
cord-023439-r04y1j22	266	23	cows	cow	NNS
cord-023439-r04y1j22	266	24	to	to	TO
cord-023439-r04y1j22	266	25	produce	produce	VB
cord-023439-r04y1j22	266	26	the	the	DT
cord-023439-r04y1j22	266	27	proinflammatory	proinflammatory	JJ
cord-023439-r04y1j22	266	28	cytokine	cytokine	NN
cord-023439-r04y1j22	266	29	tumour	tumour	NN
cord-023439-r04y1j22	266	30	necrosis	necrosis	NN
cord-023439-r04y1j22	266	31	factor	factor	NN
cord-023439-r04y1j22	266	32	-	-	:
cord-023439-r04y1j22	266	33	a	a	DT
cord-023439-r04y1j22	266	34	(	(	-LRB-
cord-023439-r04y1j22	266	35	TNF	TNF	NNP
cord-023439-r04y1j22	266	36	-	-	HYPH
cord-023439-r04y1j22	266	37	a	a	LS
cord-023439-r04y1j22	266	38	)	)	-RRB-
cord-023439-r04y1j22	266	39	ex	ex	FW
cord-023439-r04y1j22	266	40	vivo	vivo	NN
cord-023439-r04y1j22	266	41	.	.	.
cord-023439-r04y1j22	267	1	Initially	initially	RB
cord-023439-r04y1j22	267	2	,	,	,
cord-023439-r04y1j22	267	3	a	a	DT
cord-023439-r04y1j22	267	4	time	time	NN
cord-023439-r04y1j22	267	5	-	-	HYPH
cord-023439-r04y1j22	267	6	and	and	CC
cord-023439-r04y1j22	267	7	dose	dose	NN
cord-023439-r04y1j22	267	8	-	-	HYPH
cord-023439-r04y1j22	267	9	dependent	dependent	JJ
cord-023439-r04y1j22	267	10	study	study	NN
cord-023439-r04y1j22	267	11	was	be	VBD
cord-023439-r04y1j22	267	12	carried	carry	VBN
cord-023439-r04y1j22	267	13	out	out	RP
cord-023439-r04y1j22	267	14	to	to	TO
cord-023439-r04y1j22	267	15	find	find	VB
cord-023439-r04y1j22	267	16	the	the	DT
cord-023439-r04y1j22	267	17	optimal	optimal	JJ
cord-023439-r04y1j22	267	18	stimulation	stimulation	NN
cord-023439-r04y1j22	267	19	conditions	condition	NNS
cord-023439-r04y1j22	267	20	for	for	IN
cord-023439-r04y1j22	267	21	the	the	DT
cord-023439-r04y1j22	267	22	TNF	TNF	NNP
cord-023439-r04y1j22	267	23	-	-	:
cord-023439-r04y1j22	267	24	a	a	DT
cord-023439-r04y1j22	267	25	response	response	NN
cord-023439-r04y1j22	267	26	.	.	.
cord-023439-r04y1j22	268	1	The	the	DT
cord-023439-r04y1j22	268	2	TNF	TNF	NNP
cord-023439-r04y1j22	268	3	-	-	:
cord-023439-r04y1j22	268	4	a	a	DT
cord-023439-r04y1j22	268	5	response	response	NN
cord-023439-r04y1j22	268	6	peaked	peak	VBD
cord-023439-r04y1j22	268	7	between	between	IN
cord-023439-r04y1j22	268	8	3	3	CD
cord-023439-r04y1j22	268	9	and	and	CC
cord-023439-r04y1j22	268	10	4	4	CD
cord-023439-r04y1j22	268	11	h	h	NN
cord-023439-r04y1j22	268	12	at	at	IN
cord-023439-r04y1j22	268	13	38.5	38.5	CD
cord-023439-r04y1j22	268	14	C.	C.	NNP
cord-023439-r04y1j22	268	15	A	A	NNP
cord-023439-r04y1j22	268	16	dose	dose	NN
cord-023439-r04y1j22	268	17	in	in	IN
cord-023439-r04y1j22	268	18	the	the	DT
cord-023439-r04y1j22	268	19	range	range	NN
cord-023439-r04y1j22	268	20	of	of	IN
cord-023439-r04y1j22	268	21	5	5	CD
cord-023439-r04y1j22	268	22	-	-	SYM
cord-023439-r04y1j22	268	23	10	10	CD
cord-023439-r04y1j22	268	24	g	g	NN
cord-023439-r04y1j22	268	25	of	of	IN
cord-023439-r04y1j22	268	26	E.	E.	NNP
cord-023439-r04y1j22	268	27	coli	coli	NNS
cord-023439-r04y1j22	268	28	lipopolysaccharide	lipopolysaccharide	NN
cord-023439-r04y1j22	268	29	(	(	-LRB-
cord-023439-r04y1j22	268	30	LPS)/ml	lps)/ml	CD
cord-023439-r04y1j22	268	31	whole	whole	JJ
cord-023439-r04y1j22	268	32	blood	blood	NN
cord-023439-r04y1j22	268	33	was	be	VBD
cord-023439-r04y1j22	268	34	found	find	VBN
cord-023439-r04y1j22	268	35	to	to	TO
cord-023439-r04y1j22	268	36	give	give	VB
cord-023439-r04y1j22	268	37	the	the	DT
cord-023439-r04y1j22	268	38	maximum	maximum	JJ
cord-023439-r04y1j22	268	39	TNF	TNF	NNP
cord-023439-r04y1j22	268	40	-	-	:
cord-023439-r04y1j22	268	41	a	a	DT
cord-023439-r04y1j22	268	42	response	response	NN
cord-023439-r04y1j22	268	43	.	.	.
cord-023439-r04y1j22	269	1	Thirty	thirty	CD
cord-023439-r04y1j22	269	2	-	-	HYPH
cord-023439-r04y1j22	269	3	eight	eight	CD
cord-023439-r04y1j22	269	4	Danish	Danish	NNP
cord-023439-r04y1j22	269	5	-	-	HYPH
cord-023439-r04y1j22	269	6	Holstein	Holstein	NNP
cord-023439-r04y1j22	269	7	dairy	dairy	NN
cord-023439-r04y1j22	269	8	cows	cow	NNS
cord-023439-r04y1j22	269	9	were	be	VBD
cord-023439-r04y1j22	269	10	investigated	investigate	VBN
cord-023439-r04y1j22	269	11	for	for	IN
cord-023439-r04y1j22	269	12	their	-PRON-	PRP$
cord-023439-r04y1j22	269	13	TNF	TNF	NNP
cord-023439-r04y1j22	269	14	-	-	:
cord-023439-r04y1j22	269	15	a	a	DT
cord-023439-r04y1j22	269	16	responsiveness	responsiveness	NN
cord-023439-r04y1j22	269	17	ex	ex	FW
cord-023439-r04y1j22	269	18	vivo	vivo	NN
cord-023439-r04y1j22	269	19	in	in	IN
cord-023439-r04y1j22	269	20	the	the	DT
cord-023439-r04y1j22	269	21	periparturient	periparturient	JJ
cord-023439-r04y1j22	269	22	period	period	NN
cord-023439-r04y1j22	269	23	.	.	.
cord-023439-r04y1j22	270	1	Heparin	Heparin	NNP
cord-023439-r04y1j22	270	2	-	-	HYPH
cord-023439-r04y1j22	270	3	stabilized	stabilize	VBN
cord-023439-r04y1j22	270	4	blood	blood	NN
cord-023439-r04y1j22	270	5	samples	sample	NNS
cord-023439-r04y1j22	270	6	were	be	VBD
cord-023439-r04y1j22	270	7	collected	collect	VBN
cord-023439-r04y1j22	270	8	seven	seven	CD
cord-023439-r04y1j22	270	9	times	time	NNS
cord-023439-r04y1j22	270	10	over	over	IN
cord-023439-r04y1j22	270	11	a	a	DT
cord-023439-r04y1j22	270	12	period	period	NN
cord-023439-r04y1j22	270	13	of	of	IN
cord-023439-r04y1j22	270	14	4	4	CD
cord-023439-r04y1j22	270	15	months	month	NNS
cord-023439-r04y1j22	270	16	(	(	-LRB-
cord-023439-r04y1j22	270	17	weeks	week	NNS
cord-023439-r04y1j22	270	18	À3	à3	CD
cord-023439-r04y1j22	270	19	,	,	,
cord-023439-r04y1j22	270	20	À1	À1	NNP
cord-023439-r04y1j22	270	21	,	,	,
cord-023439-r04y1j22	270	22	2	2	CD
cord-023439-r04y1j22	270	23	,	,	,
cord-023439-r04y1j22	270	24	3	3	CD
cord-023439-r04y1j22	270	25	,	,	,
cord-023439-r04y1j22	270	26	5	5	CD
cord-023439-r04y1j22	270	27	,	,	,
cord-023439-r04y1j22	270	28	9	9	CD
cord-023439-r04y1j22	270	29	and	and	CC
cord-023439-r04y1j22	270	30	13	13	CD
cord-023439-r04y1j22	270	31	around	around	IN
cord-023439-r04y1j22	270	32	calving	calving	NN
cord-023439-r04y1j22	270	33	)	)	-RRB-
cord-023439-r04y1j22	270	34	and	and	CC
cord-023439-r04y1j22	270	35	stimulated	stimulate	VBD
cord-023439-r04y1j22	270	36	with	with	IN
cord-023439-r04y1j22	270	37	5	5	CD
cord-023439-r04y1j22	270	38	g	g	NN
cord-023439-r04y1j22	270	39	/	/	SYM
cord-023439-r04y1j22	270	40	ml	ml	NN
cord-023439-r04y1j22	270	41	of	of	IN
cord-023439-r04y1j22	270	42	E.	E.	NNP
cord-023439-r04y1j22	270	43	coli	coli	VBZ
cord-023439-r04y1j22	270	44	LPS	lp	NNS
cord-023439-r04y1j22	270	45	.	.	.
cord-023439-r04y1j22	271	1	Indeed	indeed	RB
cord-023439-r04y1j22	271	2	,	,	,
cord-023439-r04y1j22	271	3	fluctuations	fluctuation	NNS
cord-023439-r04y1j22	271	4	in	in	IN
cord-023439-r04y1j22	271	5	the	the	DT
cord-023439-r04y1j22	271	6	TNF	TNF	NNP
cord-023439-r04y1j22	271	7	-	-	:
cord-023439-r04y1j22	271	8	a	a	DT
cord-023439-r04y1j22	271	9	responsiveness	responsiveness	NN
cord-023439-r04y1j22	271	10	occurred	occur	VBD
cord-023439-r04y1j22	271	11	over	over	IN
cord-023439-r04y1j22	271	12	time	time	NN
cord-023439-r04y1j22	271	13	.	.	.
cord-023439-r04y1j22	272	1	Moreover	moreover	RB
cord-023439-r04y1j22	272	2	,	,	,
cord-023439-r04y1j22	272	3	the	the	DT
cord-023439-r04y1j22	272	4	mean	mean	JJ
cord-023439-r04y1j22	272	5	TNF	TNF	NNP
cord-023439-r04y1j22	272	6	-	-	:
cord-023439-r04y1j22	272	7	a	a	DT
cord-023439-r04y1j22	272	8	responsiveness	responsiveness	NN
cord-023439-r04y1j22	272	9	of	of	IN
cord-023439-r04y1j22	272	10	38	38	CD
cord-023439-r04y1j22	272	11	cows	cow	NNS
cord-023439-r04y1j22	272	12	was	be	VBD
cord-023439-r04y1j22	272	13	found	find	VBN
cord-023439-r04y1j22	272	14	to	to	TO
cord-023439-r04y1j22	272	15	be	be	VB
cord-023439-r04y1j22	272	16	significantly	significantly	RB
cord-023439-r04y1j22	272	17	increased	increase	VBN
cord-023439-r04y1j22	272	18	(	(	-LRB-
cord-023439-r04y1j22	272	19	P	p	NN
cord-023439-r04y1j22	272	20	<	<	XX
cord-023439-r04y1j22	272	21	0.001	0.001	CD
cord-023439-r04y1j22	272	22	)	)	-RRB-
cord-023439-r04y1j22	272	23	in	in	IN
cord-023439-r04y1j22	272	24	the	the	DT
cord-023439-r04y1j22	272	25	weeks	week	NNS
cord-023439-r04y1j22	272	26	close	close	JJ
cord-023439-r04y1j22	272	27	to	to	IN
cord-023439-r04y1j22	272	28	calving	calving	NN
cord-023439-r04y1j22	272	29	.	.	.
cord-023439-r04y1j22	273	1	However	however	RB
cord-023439-r04y1j22	273	2	,	,	,
cord-023439-r04y1j22	273	3	in	in	IN
cord-023439-r04y1j22	273	4	the	the	DT
cord-023439-r04y1j22	273	5	more	more	RBR
cord-023439-r04y1j22	273	6	stabile	stabile	JJ
cord-023439-r04y1j22	273	7	physiological	physiological	JJ
cord-023439-r04y1j22	273	8	periods	period	NNS
cord-023439-r04y1j22	273	9	,	,	,
cord-023439-r04y1j22	273	10	some	some	DT
cord-023439-r04y1j22	273	11	cows	cow	NNS
cord-023439-r04y1j22	273	12	had	have	VBD
cord-023439-r04y1j22	273	13	a	a	DT
cord-023439-r04y1j22	273	14	consistently	consistently	RB
cord-023439-r04y1j22	273	15	low	low	JJ
cord-023439-r04y1j22	273	16	TNF	tnf	NN
cord-023439-r04y1j22	273	17	-	-	:
cord-023439-r04y1j22	273	18	a	a	DT
cord-023439-r04y1j22	273	19	response	response	NN
cord-023439-r04y1j22	273	20	,	,	,
cord-023439-r04y1j22	273	21	whereas	whereas	IN
cord-023439-r04y1j22	273	22	others	other	NNS
cord-023439-r04y1j22	273	23	had	have	VBD
cord-023439-r04y1j22	273	24	high	high	JJ
cord-023439-r04y1j22	273	25	a	a	DT
cord-023439-r04y1j22	273	26	TNF	TNF	NNP
cord-023439-r04y1j22	273	27	-	-	:
cord-023439-r04y1j22	273	28	a	a	DT
cord-023439-r04y1j22	273	29	response	response	NN
cord-023439-r04y1j22	273	30	.	.	.
cord-023439-r04y1j22	274	1	We	-PRON-	PRP
cord-023439-r04y1j22	274	2	are	be	VBP
cord-023439-r04y1j22	274	3	currently	currently	RB
cord-023439-r04y1j22	274	4	investigating	investigate	VBG
cord-023439-r04y1j22	274	5	whether	whether	IN
cord-023439-r04y1j22	274	6	high	high	JJ
cord-023439-r04y1j22	274	7	and	and	CC
cord-023439-r04y1j22	274	8	low	low	JJ
cord-023439-r04y1j22	274	9	TNF	tnf	NN
cord-023439-r04y1j22	274	10	-	-	:
cord-023439-r04y1j22	274	11	a	a	DT
cord-023439-r04y1j22	274	12	responders	responder	NNS
cord-023439-r04y1j22	274	13	to	to	IN
cord-023439-r04y1j22	274	14	E.	E.	NNP
cord-023439-r04y1j22	274	15	coli	coli	VBZ
cord-023439-r04y1j22	274	16	LPS	LPS	NNP
cord-023439-r04y1j22	274	17	also	also	RB
cord-023439-r04y1j22	274	18	exist	exist	VBP
cord-023439-r04y1j22	274	19	in	in	IN
cord-023439-r04y1j22	274	20	dairy	dairy	NN
cord-023439-r04y1j22	274	21	cows	cow	NNS
cord-023439-r04y1j22	274	22	in	in	IN
cord-023439-r04y1j22	274	23	vivo	vivo	NN
cord-023439-r04y1j22	274	24	.	.	.
cord-023439-r04y1j22	275	1	Moreover	moreover	RB
cord-023439-r04y1j22	275	2	,	,	,
cord-023439-r04y1j22	275	3	the	the	DT
cord-023439-r04y1j22	275	4	importance	importance	NN
cord-023439-r04y1j22	275	5	of	of	IN
cord-023439-r04y1j22	275	6	TNF	TNF	NNP
cord-023439-r04y1j22	275	7	-	-	:
cord-023439-r04y1j22	275	8	a	a	DT
cord-023439-r04y1j22	275	9	responsiveness	responsiveness	NN
cord-023439-r04y1j22	275	10	ex	ex	FW
cord-023439-r04y1j22	275	11	vivo	vivo	NN
cord-023439-r04y1j22	275	12	to	to	IN
cord-023439-r04y1j22	275	13	dairy	dairy	NN
cord-023439-r04y1j22	275	14	cows	cow	NNS
cord-023439-r04y1j22	275	15	'	'	POS
cord-023439-r04y1j22	275	16	susceptibility	susceptibility	NN
cord-023439-r04y1j22	275	17	and	and	CC
cord-023439-r04y1j22	275	18	clinical	clinical	JJ
cord-023439-r04y1j22	275	19	response	response	NN
cord-023439-r04y1j22	275	20	to	to	IN
cord-023439-r04y1j22	275	21	experimental	experimental	JJ
cord-023439-r04y1j22	275	22	E.	E.	NNP
cord-023439-r04y1j22	275	23	coli	coli	VBZ
cord-023439-r04y1j22	275	24	infections	infection	NNS
cord-023439-r04y1j22	275	25	in	in	IN
cord-023439-r04y1j22	275	26	the	the	DT
cord-023439-r04y1j22	275	27	udder	udder	NN
cord-023439-r04y1j22	275	28	is	be	VBZ
cord-023439-r04y1j22	275	29	being	be	VBG
cord-023439-r04y1j22	275	30	investigated	investigate	VBN
cord-023439-r04y1j22	275	31	.	.	.
cord-023439-r04y1j22	276	1	Coelomic	Coelomic	NNP
cord-023439-r04y1j22	276	2	cytolytic	cytolytic	JJ
cord-023439-r04y1j22	276	3	factor	factor	NN
cord-023439-r04y1j22	276	4	(	(	-LRB-
cord-023439-r04y1j22	276	5	CCF	CCF	NNP
cord-023439-r04y1j22	276	6	)	)	-RRB-
cord-023439-r04y1j22	276	7	is	be	VBZ
cord-023439-r04y1j22	276	8	a	a	DT
cord-023439-r04y1j22	276	9	42	42	CD
cord-023439-r04y1j22	276	10	kDa	kDa	NNP
cord-023439-r04y1j22	276	11	invertebrate	invertebrate	NN
cord-023439-r04y1j22	276	12	pattern	pattern	NN
cord-023439-r04y1j22	276	13	recognition	recognition	NN
cord-023439-r04y1j22	276	14	molecule	molecule	NN
cord-023439-r04y1j22	276	15	isolated	isolate	VBN
cord-023439-r04y1j22	276	16	from	from	IN
cord-023439-r04y1j22	276	17	the	the	DT
cord-023439-r04y1j22	276	18	coelomic	coelomic	NNP
cord-023439-r04y1j22	276	19	fluid	fluid	NN
cord-023439-r04y1j22	276	20	of	of	IN
cord-023439-r04y1j22	276	21	the	the	DT
cord-023439-r04y1j22	276	22	earthworm	earthworm	NN
cord-023439-r04y1j22	276	23	Eisenia	Eisenia	NNP
cord-023439-r04y1j22	276	24	foetida	foetida	NNP
cord-023439-r04y1j22	276	25	(	(	-LRB-
cord-023439-r04y1j22	276	26	Oligochaeta	Oligochaeta	NNP
cord-023439-r04y1j22	276	27	,	,	,
cord-023439-r04y1j22	276	28	Annelida	Annelida	NNP
cord-023439-r04y1j22	276	29	)	)	-RRB-
cord-023439-r04y1j22	276	30	.	.	.
cord-023439-r04y1j22	277	1	CCF	CCF	NNP
cord-023439-r04y1j22	277	2	displays	display	VBZ
cord-023439-r04y1j22	277	3	a	a	DT
cord-023439-r04y1j22	277	4	number	number	NN
cord-023439-r04y1j22	277	5	of	of	IN
cord-023439-r04y1j22	277	6	similarities	similarity	NNS
cord-023439-r04y1j22	277	7	with	with	IN
cord-023439-r04y1j22	277	8	the	the	DT
cord-023439-r04y1j22	277	9	mammalian	mammalian	JJ
cord-023439-r04y1j22	277	10	cytokine	cytokine	NN
cord-023439-r04y1j22	277	11	tumour	tumour	NN
cord-023439-r04y1j22	277	12	necrosis	necrosis	NN
cord-023439-r04y1j22	277	13	factor	factor	NN
cord-023439-r04y1j22	277	14	-	-	:
cord-023439-r04y1j22	277	15	a	a	NN
cord-023439-r04y1j22	277	16	(	(	-LRB-
cord-023439-r04y1j22	277	17	TNFa	TNFa	NNP
cord-023439-r04y1j22	277	18	)	)	-RRB-
cord-023439-r04y1j22	277	19	as	as	IN
cord-023439-r04y1j22	277	20	a	a	DT
cord-023439-r04y1j22	277	21	result	result	NN
cord-023439-r04y1j22	277	22	of	of	IN
cord-023439-r04y1j22	277	23	a	a	DT
cord-023439-r04y1j22	277	24	shared	shared	JJ
cord-023439-r04y1j22	277	25	N	N	NNP
cord-023439-r04y1j22	277	26	,	,	,
cord-023439-r04y1j22	277	27	N	n	CD
cord-023439-r04y1j22	277	28	0	0	CD
cord-023439-r04y1j22	277	29	-diacetylchitobiose	-diacetylchitobiose	HYPH
cord-023439-r04y1j22	277	30	lectin	lectin	NN
cord-023439-r04y1j22	277	31	-	-	HYPH
cord-023439-r04y1j22	277	32	like	like	JJ
cord-023439-r04y1j22	277	33	domain	domain	NN
cord-023439-r04y1j22	277	34	.	.	.
cord-023439-r04y1j22	278	1	However	however	RB
cord-023439-r04y1j22	278	2	,	,	,
cord-023439-r04y1j22	278	3	these	these	DT
cord-023439-r04y1j22	278	4	similarities	similarity	NNS
cord-023439-r04y1j22	278	5	are	be	VBP
cord-023439-r04y1j22	278	6	solely	solely	RB
cord-023439-r04y1j22	278	7	functional	functional	JJ
cord-023439-r04y1j22	278	8	and	and	CC
cord-023439-r04y1j22	278	9	are	be	VBP
cord-023439-r04y1j22	278	10	not	not	RB
cord-023439-r04y1j22	278	11	based	base	VBN
cord-023439-r04y1j22	278	12	on	on	IN
cord-023439-r04y1j22	278	13	any	any	DT
cord-023439-r04y1j22	278	14	(	(	-LRB-
cord-023439-r04y1j22	278	15	DNA	dna	NN
cord-023439-r04y1j22	278	16	or	or	CC
cord-023439-r04y1j22	278	17	amino	amino	NN
cord-023439-r04y1j22	278	18	acid	acid	NN
cord-023439-r04y1j22	278	19	)	)	-RRB-
cord-023439-r04y1j22	278	20	sequence	sequence	NN
cord-023439-r04y1j22	278	21	homology	homology	NN
cord-023439-r04y1j22	278	22	,	,	,
cord-023439-r04y1j22	278	23	thus	thus	RB
cord-023439-r04y1j22	278	24	suggesting	suggest	VBG
cord-023439-r04y1j22	278	25	a	a	DT
cord-023439-r04y1j22	278	26	form	form	NN
cord-023439-r04y1j22	278	27	of	of	IN
cord-023439-r04y1j22	278	28	convergent	convergent	JJ
cord-023439-r04y1j22	278	29	evolution	evolution	NN
cord-023439-r04y1j22	278	30	.	.	.
cord-023439-r04y1j22	279	1	In	in	IN
cord-023439-r04y1j22	279	2	particular	particular	JJ
cord-023439-r04y1j22	279	3	,	,	,
cord-023439-r04y1j22	279	4	the	the	DT
cord-023439-r04y1j22	279	5	lectin	lectin	NN
cord-023439-r04y1j22	279	6	-	-	HYPH
cord-023439-r04y1j22	279	7	like	like	JJ
cord-023439-r04y1j22	279	8	domain	domain	NN
cord-023439-r04y1j22	279	9	of	of	IN
cord-023439-r04y1j22	279	10	TNF	TNF	NNP
cord-023439-r04y1j22	279	11	-	-	:
cord-023439-r04y1j22	279	12	a	a	NNP
cord-023439-r04y1j22	279	13	has	have	VBZ
cord-023439-r04y1j22	279	14	been	be	VBN
cord-023439-r04y1j22	279	15	shown	show	VBN
cord-023439-r04y1j22	279	16	to	to	TO
cord-023439-r04y1j22	279	17	induce	induce	VB
cord-023439-r04y1j22	279	18	membrane	membrane	NN
cord-023439-r04y1j22	279	19	depolarization	depolarization	NN
cord-023439-r04y1j22	279	20	in	in	IN
cord-023439-r04y1j22	279	21	various	various	JJ
cord-023439-r04y1j22	279	22	mammalian	mammalian	JJ
cord-023439-r04y1j22	279	23	cell	cell	NN
cord-023439-r04y1j22	279	24	types	type	NNS
cord-023439-r04y1j22	279	25	,	,	,
cord-023439-r04y1j22	279	26	through	through	IN
cord-023439-r04y1j22	279	27	interactions	interaction	NNS
cord-023439-r04y1j22	279	28	with	with	IN
cord-023439-r04y1j22	279	29	endogenous	endogenous	JJ
cord-023439-r04y1j22	279	30	amiloride	amiloride	NN
cord-023439-r04y1j22	279	31	-	-	HYPH
cord-023439-r04y1j22	279	32	sensitive	sensitive	JJ
cord-023439-r04y1j22	279	33	ion	ion	NN
cord-023439-r04y1j22	279	34	channels	channel	NNS
cord-023439-r04y1j22	279	35	.	.	.
cord-023439-r04y1j22	280	1	This	this	DT
cord-023439-r04y1j22	280	2	nonreceptor	nonreceptor	RB
cord-023439-r04y1j22	280	3	-	-	HYPH
cord-023439-r04y1j22	280	4	mediated	mediate	VBN
cord-023439-r04y1j22	280	5	activity	activity	NN
cord-023439-r04y1j22	280	6	of	of	IN
cord-023439-r04y1j22	280	7	TNF	TNF	NNP
cord-023439-r04y1j22	280	8	-	-	:
cord-023439-r04y1j22	280	9	a	a	NNP
cord-023439-r04y1j22	280	10	has	have	VBZ
cord-023439-r04y1j22	280	11	been	be	VBN
cord-023439-r04y1j22	280	12	reported	report	VBN
cord-023439-r04y1j22	280	13	to	to	TO
cord-023439-r04y1j22	280	14	be	be	VB
cord-023439-r04y1j22	280	15	involved	involve	VBN
cord-023439-r04y1j22	280	16	in	in	IN
cord-023439-r04y1j22	280	17	the	the	DT
cord-023439-r04y1j22	280	18	resorption	resorption	NN
cord-023439-r04y1j22	280	19	of	of	IN
cord-023439-r04y1j22	280	20	oedema	oedema	NN
cord-023439-r04y1j22	280	21	.	.	.
cord-023439-r04y1j22	281	1	Likewise	likewise	RB
cord-023439-r04y1j22	281	2	,	,	,
cord-023439-r04y1j22	281	3	the	the	DT
cord-023439-r04y1j22	281	4	lectin	lectin	NN
cord-023439-r04y1j22	281	5	-	-	HYPH
cord-023439-r04y1j22	281	6	like	like	JJ
cord-023439-r04y1j22	281	7	domain	domain	NN
cord-023439-r04y1j22	281	8	of	of	IN
cord-023439-r04y1j22	281	9	CCF	CCF	NNP
cord-023439-r04y1j22	281	10	also	also	RB
cord-023439-r04y1j22	281	11	induces	induce	VBZ
cord-023439-r04y1j22	281	12	membrane	membrane	NN
cord-023439-r04y1j22	281	13	depolarization	depolarization	NN
cord-023439-r04y1j22	281	14	in	in	IN
cord-023439-r04y1j22	281	15	mammalian	mammalian	JJ
cord-023439-r04y1j22	281	16	cells	cell	NNS
cord-023439-r04y1j22	281	17	.	.	.
cord-023439-r04y1j22	282	1	Here	here	RB
cord-023439-r04y1j22	282	2	,	,	,
cord-023439-r04y1j22	282	3	we	-PRON-	PRP
cord-023439-r04y1j22	282	4	show	show	VBP
cord-023439-r04y1j22	282	5	that	that	IN
cord-023439-r04y1j22	282	6	CCF	CCF	NNP
cord-023439-r04y1j22	282	7	appears	appear	VBZ
cord-023439-r04y1j22	282	8	to	to	TO
cord-023439-r04y1j22	282	9	be	be	VB
cord-023439-r04y1j22	282	10	able	able	JJ
cord-023439-r04y1j22	282	11	to	to	TO
cord-023439-r04y1j22	282	12	induce	induce	VB
cord-023439-r04y1j22	282	13	oedema	oedema	NN
cord-023439-r04y1j22	282	14	resorption	resorption	NN
cord-023439-r04y1j22	282	15	in	in	IN
cord-023439-r04y1j22	282	16	an	an	DT
cord-023439-r04y1j22	282	17	alveolar	alveolar	JJ
cord-023439-r04y1j22	282	18	epithelial	epithelial	JJ
cord-023439-r04y1j22	282	19	cell	cell	NN
cord-023439-r04y1j22	282	20	line	line	NN
cord-023439-r04y1j22	282	21	through	through	IN
cord-023439-r04y1j22	282	22	its	-PRON-	PRP$
cord-023439-r04y1j22	282	23	lectin	lectin	NN
cord-023439-r04y1j22	282	24	-	-	HYPH
cord-023439-r04y1j22	282	25	like	like	JJ
cord-023439-r04y1j22	282	26	domain	domain	NN
cord-023439-r04y1j22	282	27	.	.	.
cord-023439-r04y1j22	283	1	This	this	DT
cord-023439-r04y1j22	283	2	lectin	lectin	NN
cord-023439-r04y1j22	283	3	-	-	HYPH
cord-023439-r04y1j22	283	4	like	like	JJ
cord-023439-r04y1j22	283	5	domain	domain	NN
cord-023439-r04y1j22	283	6	of	of	IN
cord-023439-r04y1j22	283	7	CCF	CCF	NNP
cord-023439-r04y1j22	283	8	interacts	interact	VBZ
cord-023439-r04y1j22	283	9	(	(	-LRB-
cord-023439-r04y1j22	283	10	directly	directly	RB
cord-023439-r04y1j22	283	11	or	or	CC
cord-023439-r04y1j22	283	12	indirectly	indirectly	RB
cord-023439-r04y1j22	283	13	)	)	-RRB-
cord-023439-r04y1j22	283	14	with	with	IN
cord-023439-r04y1j22	283	15	endogenous	endogenous	JJ
cord-023439-r04y1j22	283	16	sodium	sodium	NN
cord-023439-r04y1j22	283	17	and/or	and/or	CC
cord-023439-r04y1j22	283	18	chloride	chloride	NN
cord-023439-r04y1j22	283	19	channels	channel	NNS
cord-023439-r04y1j22	283	20	,	,	,
cord-023439-r04y1j22	283	21	and	and	CC
cord-023439-r04y1j22	283	22	not	not	RB
cord-023439-r04y1j22	283	23	potassium	potassium	NN
cord-023439-r04y1j22	283	24	channels	channel	NNS
cord-023439-r04y1j22	283	25	,	,	,
cord-023439-r04y1j22	283	26	on	on	IN
cord-023439-r04y1j22	283	27	mammalian	mammalian	JJ
cord-023439-r04y1j22	283	28	cells	cell	NNS
cord-023439-r04y1j22	283	29	.	.	.
cord-023439-r04y1j22	284	1	Additionally	additionally	RB
cord-023439-r04y1j22	284	2	,	,	,
cord-023439-r04y1j22	284	3	we	-PRON-	PRP
cord-023439-r04y1j22	284	4	suggest	suggest	VBP
cord-023439-r04y1j22	284	5	that	that	IN
cord-023439-r04y1j22	284	6	the	the	DT
cord-023439-r04y1j22	284	7	JNK	JNK	NNP
cord-023439-r04y1j22	284	8	/	/	SYM
cord-023439-r04y1j22	284	9	SAPK	SAPK	NNP
cord-023439-r04y1j22	284	10	and	and	CC
cord-023439-r04y1j22	284	11	Erk1/2	Erk1/2	NNP
cord-023439-r04y1j22	284	12	pathways	pathway	NNS
cord-023439-r04y1j22	284	13	are	be	VBP
cord-023439-r04y1j22	284	14	involved	involve	VBN
cord-023439-r04y1j22	284	15	in	in	IN
cord-023439-r04y1j22	284	16	CCF	CCF	NNP
cord-023439-r04y1j22	284	17	-	-	HYPH
cord-023439-r04y1j22	284	18	induced	induce	VBN
cord-023439-r04y1j22	284	19	macrophage	macrophage	NN
cord-023439-r04y1j22	284	20	activation	activation	NN
cord-023439-r04y1j22	284	21	.	.	.
cord-023439-r04y1j22	285	1	These	these	DT
cord-023439-r04y1j22	285	2	results	result	NNS
cord-023439-r04y1j22	285	3	further	further	RB
cord-023439-r04y1j22	285	4	establish	establish	VBP
cord-023439-r04y1j22	285	5	the	the	DT
cord-023439-r04y1j22	285	6	functional	functional	JJ
cord-023439-r04y1j22	285	7	analogy	analogy	NN
cord-023439-r04y1j22	285	8	between	between	IN
cord-023439-r04y1j22	285	9	an	an	DT
cord-023439-r04y1j22	285	10	invertebrate	invertebrate	JJ
cord-023439-r04y1j22	285	11	pattern	pattern	NN
cord-023439-r04y1j22	285	12	recognition	recognition	NN
cord-023439-r04y1j22	285	13	molecule	molecule	NN
cord-023439-r04y1j22	285	14	and	and	CC
cord-023439-r04y1j22	285	15	a	a	DT
cord-023439-r04y1j22	285	16	mammalian	mammalian	JJ
cord-023439-r04y1j22	285	17	cytokine	cytokine	NN
cord-023439-r04y1j22	285	18	and	and	CC
cord-023439-r04y1j22	285	19	,	,	,
cord-023439-r04y1j22	285	20	from	from	IN
cord-023439-r04y1j22	285	21	a	a	DT
cord-023439-r04y1j22	285	22	more	more	RBR
cord-023439-r04y1j22	285	23	applied	applied	JJ
cord-023439-r04y1j22	285	24	point	point	NN
cord-023439-r04y1j22	285	25	of	of	IN
cord-023439-r04y1j22	285	26	view	view	NN
cord-023439-r04y1j22	285	27	,	,	,
cord-023439-r04y1j22	285	28	suggest	suggest	VBP
cord-023439-r04y1j22	285	29	the	the	DT
cord-023439-r04y1j22	285	30	possibility	possibility	NN
cord-023439-r04y1j22	285	31	of	of	IN
cord-023439-r04y1j22	285	32	utilizing	utilize	VBG
cord-023439-r04y1j22	285	33	CCF	CCF	NNP
cord-023439-r04y1j22	285	34	in	in	IN
cord-023439-r04y1j22	285	35	the	the	DT
cord-023439-r04y1j22	285	36	treatment	treatment	NN
cord-023439-r04y1j22	285	37	of	of	IN
cord-023439-r04y1j22	285	38	oedema	oedema	NN
cord-023439-r04y1j22	285	39	.	.	.
cord-023439-r04y1j22	286	1	Release	Release	NNP
cord-023439-r04y1j22	286	2	of	of	IN
cord-023439-r04y1j22	286	3	sVEGF	svegf	NN
cord-023439-r04y1j22	286	4	and	and	CC
cord-023439-r04y1j22	286	5	sVEGFR1	svegfr1	NN
cord-023439-r04y1j22	286	6	from	from	IN
cord-023439-r04y1j22	286	7	White	White	NNP
cord-023439-r04y1j22	286	8	Blood	Blood	NNP
cord-023439-r04y1j22	286	9	Cells	Cells	NNPS
cord-023439-r04y1j22	286	10	and	and	CC
cord-023439-r04y1j22	286	11	Platelets	platelet	NNS
cord-023439-r04y1j22	286	12	During	during	IN
cord-023439-r04y1j22	286	13	Surgery	surgery	NN
cord-023439-r04y1j22	286	14	and	and	CC
cord-023439-r04y1j22	286	15	Stimulation	stimulation	NN
cord-023439-r04y1j22	286	16	with	with	IN
cord-023439-r04y1j22	286	17	Bacterial	bacterial	JJ
cord-023439-r04y1j22	286	18	Antigens	antigen	NNS
cord-023439-r04y1j22	286	19	Introduction	introduction	NN
cord-023439-r04y1j22	286	20	:	:	:
cord-023439-r04y1j22	287	1	The	the	DT
cord-023439-r04y1j22	287	2	influence	influence	NN
cord-023439-r04y1j22	287	3	of	of	IN
cord-023439-r04y1j22	287	4	surgery	surgery	NN
cord-023439-r04y1j22	287	5	on	on	IN
cord-023439-r04y1j22	287	6	release	release	NN
cord-023439-r04y1j22	287	7	of	of	IN
cord-023439-r04y1j22	287	8	soluble	soluble	JJ
cord-023439-r04y1j22	287	9	vascular	vascular	JJ
cord-023439-r04y1j22	287	10	endothelial	endothelial	JJ
cord-023439-r04y1j22	287	11	growth	growth	NN
cord-023439-r04y1j22	287	12	factor	factor	NN
cord-023439-r04y1j22	287	13	(	(	-LRB-
cord-023439-r04y1j22	287	14	sVEGF	sVEGF	NNP
cord-023439-r04y1j22	287	15	)	)	-RRB-
cord-023439-r04y1j22	287	16	and	and	CC
cord-023439-r04y1j22	287	17	the	the	DT
cord-023439-r04y1j22	287	18	soluble	soluble	JJ
cord-023439-r04y1j22	287	19	vascular	vascular	JJ
cord-023439-r04y1j22	287	20	endothelial	endothelial	JJ
cord-023439-r04y1j22	287	21	growth	growth	NN
cord-023439-r04y1j22	287	22	factor	factor	NN
cord-023439-r04y1j22	287	23	inhibitory	inhibitory	JJ
cord-023439-r04y1j22	287	24	receptor	receptor	NN
cord-023439-r04y1j22	287	25	1	1	CD
cord-023439-r04y1j22	287	26	(	(	-LRB-
cord-023439-r04y1j22	287	27	sVEGFR1	sVEGFR1	NNP
cord-023439-r04y1j22	287	28	)	)	-RRB-
cord-023439-r04y1j22	287	29	is	be	VBZ
cord-023439-r04y1j22	287	30	unknown	unknown	JJ
cord-023439-r04y1j22	287	31	.	.	.
cord-023439-r04y1j22	288	1	We	-PRON-	PRP
cord-023439-r04y1j22	288	2	studied	study	VBD
cord-023439-r04y1j22	288	3	the	the	DT
cord-023439-r04y1j22	288	4	effect	effect	NN
cord-023439-r04y1j22	288	5	of	of	IN
cord-023439-r04y1j22	288	6	major	major	JJ
cord-023439-r04y1j22	288	7	and	and	CC
cord-023439-r04y1j22	288	8	minor	minor	JJ
cord-023439-r04y1j22	288	9	surgery	surgery	NN
cord-023439-r04y1j22	288	10	on	on	IN
cord-023439-r04y1j22	288	11	potential	potential	JJ
cord-023439-r04y1j22	288	12	variations	variation	NNS
cord-023439-r04y1j22	288	13	in	in	IN
cord-023439-r04y1j22	288	14	sVEGF	svegf	NN
cord-023439-r04y1j22	288	15	and	and	CC
cord-023439-r04y1j22	288	16	sVEGFR1	svegfr1	JJ
cord-023439-r04y1j22	288	17	concentrations	concentration	NNS
cord-023439-r04y1j22	288	18	in	in	IN
cord-023439-r04y1j22	288	19	vivo	vivo	NN
cord-023439-r04y1j22	288	20	and	and	CC
cord-023439-r04y1j22	288	21	on	on	IN
cord-023439-r04y1j22	288	22	bacterial	bacterial	JJ
cord-023439-r04y1j22	288	23	antigen	antigen	NN
cord-023439-r04y1j22	288	24	-	-	HYPH
cord-023439-r04y1j22	288	25	induced	induce	VBN
cord-023439-r04y1j22	288	26	release	release	NN
cord-023439-r04y1j22	288	27	of	of	IN
cord-023439-r04y1j22	288	28	sVEGF	sVEGF	NNP
cord-023439-r04y1j22	288	29	and	and	CC
cord-023439-r04y1j22	288	30	sVEGFR1	svegfr1	NN
cord-023439-r04y1j22	288	31	from	from	IN
cord-023439-r04y1j22	288	32	whole	whole	JJ
cord-023439-r04y1j22	288	33	blood	blood	NN
cord-023439-r04y1j22	288	34	in	in	IN
cord-023439-r04y1j22	288	35	vitro	vitro	FW
cord-023439-r04y1j22	288	36	.	.	.
cord-023439-r04y1j22	289	1	Methods	method	NNS
cord-023439-r04y1j22	289	2	:	:	:
cord-023439-r04y1j22	289	3	Sixty	sixty	CD
cord-023439-r04y1j22	289	4	-	-	HYPH
cord-023439-r04y1j22	289	5	one	one	CD
cord-023439-r04y1j22	289	6	patients	patient	NNS
cord-023439-r04y1j22	289	7	with	with	IN
cord-023439-r04y1j22	289	8	abdominal	abdominal	JJ
cord-023439-r04y1j22	289	9	diseases	disease	NNS
cord-023439-r04y1j22	289	10	undergoing	undergo	VBG
cord-023439-r04y1j22	289	11	five	five	CD
cord-023439-r04y1j22	289	12	different	different	JJ
cord-023439-r04y1j22	289	13	surgical	surgical	JJ
cord-023439-r04y1j22	289	14	procedures	procedure	NNS
cord-023439-r04y1j22	289	15	were	be	VBD
cord-023439-r04y1j22	289	16	included	include	VBN
cord-023439-r04y1j22	289	17	.	.	.
cord-023439-r04y1j22	290	1	Blood	blood	NN
cord-023439-r04y1j22	290	2	samples	sample	NNS
cord-023439-r04y1j22	290	3	were	be	VBD
cord-023439-r04y1j22	290	4	drawn	draw	VBN
cord-023439-r04y1j22	290	5	from	from	IN
cord-023439-r04y1j22	290	6	anaesthetized	anaesthetized	JJ
cord-023439-r04y1j22	290	7	patients	patient	NNS
cord-023439-r04y1j22	290	8	before	before	IN
cord-023439-r04y1j22	290	9	and	and	CC
cord-023439-r04y1j22	290	10	after	after	IN
cord-023439-r04y1j22	290	11	the	the	DT
cord-023439-r04y1j22	290	12	operation	operation	NN
cord-023439-r04y1j22	290	13	.	.	.
cord-023439-r04y1j22	291	1	White	white	JJ
cord-023439-r04y1j22	291	2	blood	blood	NN
cord-023439-r04y1j22	291	3	cells	cell	NNS
cord-023439-r04y1j22	291	4	and	and	CC
cord-023439-r04y1j22	291	5	platelets	platelet	NNS
cord-023439-r04y1j22	291	6	were	be	VBD
cord-023439-r04y1j22	291	7	counted	count	VBN
cord-023439-r04y1j22	291	8	,	,	,
cord-023439-r04y1j22	291	9	and	and	CC
cord-023439-r04y1j22	291	10	plasma	plasma	NN
cord-023439-r04y1j22	291	11	sVEGF	svegf	NN
cord-023439-r04y1j22	291	12	and	and	CC
cord-023439-r04y1j22	291	13	sVEGFR1	sVEGFR1	NNP
cord-023439-r04y1j22	291	14	was	be	VBD
cord-023439-r04y1j22	291	15	determined	determine	VBN
cord-023439-r04y1j22	291	16	by	by	IN
cord-023439-r04y1j22	291	17	an	an	DT
cord-023439-r04y1j22	291	18	ELISA	ELISA	NNP
cord-023439-r04y1j22	291	19	method	method	NN
cord-023439-r04y1j22	291	20	.	.	.
cord-023439-r04y1j22	292	1	Whole	whole	JJ
cord-023439-r04y1j22	292	2	blood	blood	NN
cord-023439-r04y1j22	292	3	from	from	IN
cord-023439-r04y1j22	292	4	each	each	DT
cord-023439-r04y1j22	292	5	blood	blood	NN
cord-023439-r04y1j22	292	6	sample	sample	NN
cord-023439-r04y1j22	292	7	was	be	VBD
cord-023439-r04y1j22	292	8	stimulated	stimulate	VBN
cord-023439-r04y1j22	292	9	in	in	IN
cord-023439-r04y1j22	292	10	vitro	vitro	FW
cord-023439-r04y1j22	292	11	with	with	IN
cord-023439-r04y1j22	292	12	bacteria	bacteria	NNS
cord-023439-r04y1j22	292	13	-	-	HYPH
cord-023439-r04y1j22	292	14	derived	derive	VBN
cord-023439-r04y1j22	292	15	antigens	antigen	NNS
cord-023439-r04y1j22	292	16	(	(	-LRB-
cord-023439-r04y1j22	292	17	LPS	LPS	NNP
cord-023439-r04y1j22	292	18	or	or	CC
cord-023439-r04y1j22	292	19	protein	protein	NN
cord-023439-r04y1j22	292	20	-	-	HYPH
cord-023439-r04y1j22	292	21	A	a	NN
cord-023439-r04y1j22	292	22	)	)	-RRB-
cord-023439-r04y1j22	292	23	and	and	CC
cord-023439-r04y1j22	292	24	sVEGF	svegf	NN
cord-023439-r04y1j22	292	25	and	and	CC
cord-023439-r04y1j22	292	26	sVEGFR1	svegfr1	JJ
cord-023439-r04y1j22	292	27	levels	level	NNS
cord-023439-r04y1j22	292	28	were	be	VBD
cord-023439-r04y1j22	292	29	subsequently	subsequently	RB
cord-023439-r04y1j22	292	30	determined	determine	VBN
cord-023439-r04y1j22	292	31	in	in	IN
cord-023439-r04y1j22	292	32	the	the	DT
cord-023439-r04y1j22	292	33	supernatants	supernatant	NNS
cord-023439-r04y1j22	292	34	.	.	.
cord-023439-r04y1j22	293	1	Stimulation	stimulation	NN
cord-023439-r04y1j22	293	2	with	with	IN
cord-023439-r04y1j22	293	3	isotonic	isotonic	JJ
cord-023439-r04y1j22	293	4	saline	saline	NN
cord-023439-r04y1j22	293	5	served	serve	VBD
cord-023439-r04y1j22	293	6	as	as	IN
cord-023439-r04y1j22	293	7	control	control	NN
cord-023439-r04y1j22	293	8	assay	assay	NN
cord-023439-r04y1j22	293	9	.	.	.
cord-023439-r04y1j22	293	10	 	 	_SP
cord-023439-r04y1j22	294	1	Neither	neither	DT
cord-023439-r04y1j22	294	2	sVEGF	svegf	NN
cord-023439-r04y1j22	294	3	or	or	CC
cord-023439-r04y1j22	294	4	sVEGFR1	svegfr1	NN
cord-023439-r04y1j22	294	5	in	in	IN
cord-023439-r04y1j22	294	6	plasma	plasma	NN
cord-023439-r04y1j22	294	7	changed	change	VBN
cord-023439-r04y1j22	294	8	during	during	IN
cord-023439-r04y1j22	294	9	surgery	surgery	NN
cord-023439-r04y1j22	294	10	.	.	.
cord-023439-r04y1j22	295	1	In	in	IN
cord-023439-r04y1j22	295	2	vitro	vitro	FW
cord-023439-r04y1j22	295	3	stimulation	stimulation	NN
cord-023439-r04y1j22	295	4	of	of	IN
cord-023439-r04y1j22	295	5	blood	blood	NN
cord-023439-r04y1j22	295	6	samples	sample	NNS
cord-023439-r04y1j22	295	7	with	with	IN
cord-023439-r04y1j22	295	8	bacteria	bacteria	NNS
cord-023439-r04y1j22	295	9	-	-	HYPH
cord-023439-r04y1j22	295	10	derived	derive	VBN
cord-023439-r04y1j22	295	11	antigens	antigen	NNS
cord-023439-r04y1j22	295	12	resulted	result	VBD
cord-023439-r04y1j22	295	13	in	in	IN
cord-023439-r04y1j22	295	14	a	a	DT
cord-023439-r04y1j22	295	15	significant	significant	JJ
cord-023439-r04y1j22	295	16	increase	increase	NN
cord-023439-r04y1j22	295	17	in	in	IN
cord-023439-r04y1j22	295	18	sVEGF	svegf	NN
cord-023439-r04y1j22	296	1	(	(	-LRB-
cord-023439-r04y1j22	296	2	P	p	NN
cord-023439-r04y1j22	296	3	<	<	XX
cord-023439-r04y1j22	296	4	0.0001	0.0001	CD
cord-023439-r04y1j22	296	5	)	)	-RRB-
cord-023439-r04y1j22	296	6	and	and	CC
cord-023439-r04y1j22	296	7	a	a	DT
cord-023439-r04y1j22	296	8	less	less	RBR
cord-023439-r04y1j22	296	9	pronounced	pronounced	JJ
cord-023439-r04y1j22	296	10	but	but	CC
cord-023439-r04y1j22	296	11	still	still	RB
cord-023439-r04y1j22	296	12	significant	significant	JJ
cord-023439-r04y1j22	296	13	increase	increase	NN
cord-023439-r04y1j22	296	14	in	in	IN
cord-023439-r04y1j22	296	15	sVEGFR1	svegfr1	NN
cord-023439-r04y1j22	296	16	.	.	.
cord-023439-r04y1j22	297	1	Release	Release	NNP
cord-023439-r04y1j22	297	2	of	of	IN
cord-023439-r04y1j22	297	3	sVEGF	svegf	NN
cord-023439-r04y1j22	297	4	due	due	IN
cord-023439-r04y1j22	297	5	to	to	IN
cord-023439-r04y1j22	297	6	stimulation	stimulation	NN
cord-023439-r04y1j22	297	7	was	be	VBD
cord-023439-r04y1j22	297	8	significantly	significantly	RB
cord-023439-r04y1j22	297	9	higher	high	JJR
cord-023439-r04y1j22	297	10	after	after	IN
cord-023439-r04y1j22	297	11	the	the	DT
cord-023439-r04y1j22	297	12	operation	operation	NN
cord-023439-r04y1j22	297	13	(	(	-LRB-
cord-023439-r04y1j22	297	14	nonsignificant	nonsignificant	JJ
cord-023439-r04y1j22	297	15	)	)	-RRB-
cord-023439-r04y1j22	297	16	,	,	,
cord-023439-r04y1j22	297	17	whereas	whereas	IN
cord-023439-r04y1j22	297	18	sVEGFR1	sVEGFR1	NNP
cord-023439-r04y1j22	297	19	release	release	NN
cord-023439-r04y1j22	297	20	remained	remain	VBD
cord-023439-r04y1j22	297	21	largely	largely	RB
cord-023439-r04y1j22	297	22	unchanged	unchanged	JJ
cord-023439-r04y1j22	297	23	after	after	IN
cord-023439-r04y1j22	297	24	surgery	surgery	NN
cord-023439-r04y1j22	297	25	.	.	.
cord-023439-r04y1j22	298	1	Correlation	correlation	NN
cord-023439-r04y1j22	298	2	between	between	IN
cord-023439-r04y1j22	298	3	bacterial	bacterial	JJ
cord-023439-r04y1j22	298	4	antigen	antigen	NN
cord-023439-r04y1j22	298	5	-	-	HYPH
cord-023439-r04y1j22	298	6	induced	induce	VBN
cord-023439-r04y1j22	298	7	release	release	NN
cord-023439-r04y1j22	298	8	of	of	IN
cord-023439-r04y1j22	298	9	sVEGF	sVEGF	NNP
cord-023439-r04y1j22	298	10	and	and	CC
cord-023439-r04y1j22	298	11	neutrophile	neutrophile	JJ
cord-023439-r04y1j22	298	12	cell	cell	NN
cord-023439-r04y1j22	298	13	count	count	NN
cord-023439-r04y1j22	298	14	was	be	VBD
cord-023439-r04y1j22	298	15	highly	highly	RB
cord-023439-r04y1j22	298	16	significant	significant	JJ
cord-023439-r04y1j22	298	17	(	(	-LRB-
cord-023439-r04y1j22	298	18	P	p	NN
cord-023439-r04y1j22	298	19	<	<	XX
cord-023439-r04y1j22	298	20	0.0001	0.0001	CD
cord-023439-r04y1j22	298	21	)	)	-RRB-
cord-023439-r04y1j22	298	22	.	.	.
cord-023439-r04y1j22	299	1	There	there	EX
cord-023439-r04y1j22	299	2	was	be	VBD
cord-023439-r04y1j22	299	3	no	no	DT
cord-023439-r04y1j22	299	4	correlation	correlation	NN
cord-023439-r04y1j22	299	5	between	between	IN
cord-023439-r04y1j22	299	6	sVEGF	svegf	NN
cord-023439-r04y1j22	299	7	and	and	CC
cord-023439-r04y1j22	299	8	platelet	platelet	NN
cord-023439-r04y1j22	299	9	cell	cell	NN
cord-023439-r04y1j22	299	10	count	count	NN
cord-023439-r04y1j22	299	11	,	,	,
cord-023439-r04y1j22	299	12	and	and	CC
cord-023439-r04y1j22	299	13	bacterial	bacterial	JJ
cord-023439-r04y1j22	299	14	antigen	antigen	NN
cord-023439-r04y1j22	299	15	-	-	HYPH
cord-023439-r04y1j22	299	16	induced	induce	VBN
cord-023439-r04y1j22	299	17	sVEGFR1	svegfr1	NN
cord-023439-r04y1j22	299	18	release	release	NN
cord-023439-r04y1j22	299	19	did	do	VBD
cord-023439-r04y1j22	299	20	not	not	RB
cord-023439-r04y1j22	299	21	correlate	correlate	VB
cord-023439-r04y1j22	299	22	with	with	IN
cord-023439-r04y1j22	299	23	counts	count	NNS
cord-023439-r04y1j22	299	24	of	of	IN
cord-023439-r04y1j22	299	25	neutrophils	neutrophil	NNS
cord-023439-r04y1j22	299	26	and	and	CC
cord-023439-r04y1j22	299	27	platelets	platelet	NNS
cord-023439-r04y1j22	299	28	.	.	.
cord-023439-r04y1j22	300	1	Conclusions	conclusion	NNS
cord-023439-r04y1j22	300	2	:	:	:
cord-023439-r04y1j22	301	1	Plasma	plasma	NN
cord-023439-r04y1j22	301	2	sVEGF	svegf	NN
cord-023439-r04y1j22	301	3	and	and	CC
cord-023439-r04y1j22	301	4	sVEGFR1	svegfr1	NN
cord-023439-r04y1j22	301	5	concentrations	concentration	NNS
cord-023439-r04y1j22	301	6	did	do	VBD
cord-023439-r04y1j22	301	7	not	not	RB
cord-023439-r04y1j22	301	8	change	change	VB
cord-023439-r04y1j22	301	9	during	during	IN
cord-023439-r04y1j22	301	10	surgery	surgery	NN
cord-023439-r04y1j22	301	11	.	.	.
cord-023439-r04y1j22	302	1	In	in	IN
cord-023439-r04y1j22	302	2	vitro	vitro	FW
cord-023439-r04y1j22	302	3	bacterial	bacterial	JJ
cord-023439-r04y1j22	302	4	stimulation	stimulation	NN
cord-023439-r04y1j22	302	5	led	lead	VBD
cord-023439-r04y1j22	302	6	to	to	IN
cord-023439-r04y1j22	302	7	increased	increase	VBN
cord-023439-r04y1j22	302	8	release	release	NN
cord-023439-r04y1j22	302	9	of	of	IN
cord-023439-r04y1j22	302	10	sVEGF	sVEGF	NNP
cord-023439-r04y1j22	302	11	and	and	CC
cord-023439-r04y1j22	302	12	sVEGFR1	sVEGFR1	NNP
cord-023439-r04y1j22	302	13	,	,	,
cord-023439-r04y1j22	302	14	which	which	WDT
cord-023439-r04y1j22	302	15	was	be	VBD
cord-023439-r04y1j22	302	16	not	not	RB
cord-023439-r04y1j22	302	17	significantly	significantly	RB
cord-023439-r04y1j22	302	18	amplified	amplify	VBN
cord-023439-r04y1j22	302	19	during	during	IN
cord-023439-r04y1j22	302	20	surgery	surgery	NN
cord-023439-r04y1j22	302	21	and	and	CC
cord-023439-r04y1j22	302	22	which	which	WDT
cord-023439-r04y1j22	302	23	may	may	MD
cord-023439-r04y1j22	302	24	be	be	VB
cord-023439-r04y1j22	302	25	related	relate	VBN
cord-023439-r04y1j22	302	26	to	to	IN
cord-023439-r04y1j22	302	27	number	number	NN
cord-023439-r04y1j22	302	28	of	of	IN
cord-023439-r04y1j22	302	29	circulating	circulate	VBG
cord-023439-r04y1j22	302	30	neutrophils	neutrophil	NNS
cord-023439-r04y1j22	302	31	.	.	.
cord-023439-r04y1j22	303	1	Natural	natural	JJ
cord-023439-r04y1j22	303	2	Killer	Killer	NNP
cord-023439-r04y1j22	303	3	Cell	Cell	NNP
cord-023439-r04y1j22	303	4	Functions	Functions	NNPS
cord-023439-r04y1j22	303	5	and	and	CC
cord-023439-r04y1j22	303	6	Subsets	subset	NNS
cord-023439-r04y1j22	304	1	After	after	IN
cord-023439-r04y1j22	304	2	In	in	IN
cord-023439-r04y1j22	304	3	Vitro	vitro	JJ
cord-023439-r04y1j22	304	4	Stimulation	stimulation	NN
cord-023439-r04y1j22	304	5	with	with	IN
cord-023439-r04y1j22	304	6	IL-2	IL-2	NNP
cord-023439-r04y1j22	304	7	and	and	CC
cord-023439-r04y1j22	304	8	IL-12	IL-12	NNP
cord-023439-r04y1j22	304	9	,	,	,
cord-023439-r04y1j22	304	10	with	with	IN
cord-023439-r04y1j22	304	11	Special	Special	NNP
cord-023439-r04y1j22	304	12	Emphasis	Emphasis	NNP
cord-023439-r04y1j22	304	13	on	on	IN
cord-023439-r04y1j22	304	14	Intracellular	Intracellular	NNP
cord-023439-r04y1j22	304	15	IFN	IFN	NNP
cord-023439-r04y1j22	304	16	-	-	HYPH
cord-023439-r04y1j22	304	17	g	g	NNP
cord-023439-r04y1j22	304	18	and	and	CC
cord-023439-r04y1j22	305	1	NK	NK	NNP
cord-023439-r04y1j22	305	2	-	-	HYPH
cord-023439-r04y1j22	305	3	Cell	Cell	NNP
cord-023439-r04y1j22	305	4	Cytotoxicity	Cytotoxicity	NNP
cord-023439-r04y1j22	305	5	R.	R.	NNP
cord-023439-r04y1j22	305	6	Nyboe	Nyboe	NNP
cord-023439-r04y1j22	305	7	,	,	,
cord-023439-r04y1j22	305	8	1,2	1,2	CD
cord-023439-r04y1j22	305	9	T.	T.	NNP
cord-023439-r04y1j22	305	10	Rix	Rix	NNP
cord-023439-r04y1j22	305	11	,	,	,
cord-023439-r04y1j22	305	12	1,2	1,2	CD
cord-023439-r04y1j22	305	13	J.	J.	NNP
cord-023439-r04y1j22	305	14	Krog	Krog	NNP
cord-023439-r04y1j22	305	15	,	,	,
cord-023439-r04y1j22	305	16	1,2	1,2	CD
cord-023439-r04y1j22	305	17	E.	E.	NNP
cord-023439-r04y1j22	305	18	Tønnesen	Tønnesen	NNP
cord-023439-r04y1j22	305	19	1	1	CD
cord-023439-r04y1j22	305	20	&	&	CC
cord-023439-r04y1j22	305	21	M.	M.	NNP
cord-023439-r04y1j22	305	22	Hokland	Hokland	NNP
cord-023439-r04y1j22	305	23	2	2	CD
cord-023439-r04y1j22	305	24	1	1	CD
cord-023439-r04y1j22	305	25	Department	Department	NNP
cord-023439-r04y1j22	305	26	of	of	IN
cord-023439-r04y1j22	305	27	Anaesthesiology	Anaesthesiology	NNP
cord-023439-r04y1j22	305	28	and	and	CC
cord-023439-r04y1j22	305	29	Intensive	Intensive	NNP
cord-023439-r04y1j22	305	30	Care	Care	NNP
cord-023439-r04y1j22	305	31	,	,	,
cord-023439-r04y1j22	305	32	Aarhus	Aarhus	NNP
cord-023439-r04y1j22	305	33	University	University	NNP
cord-023439-r04y1j22	305	34	hospital	hospital	NN
cord-023439-r04y1j22	305	35	,	,	,
cord-023439-r04y1j22	305	36	and	and	CC
cord-023439-r04y1j22	305	37	2	2	CD
cord-023439-r04y1j22	305	38	Institute	Institute	NNP
cord-023439-r04y1j22	305	39	of	of	IN
cord-023439-r04y1j22	305	40	Medical	Medical	NNP
cord-023439-r04y1j22	305	41	Microbiology	Microbiology	NNP
cord-023439-r04y1j22	305	42	,	,	,
cord-023439-r04y1j22	305	43	and	and	CC
cord-023439-r04y1j22	305	44	Immunology	Immunology	NNP
cord-023439-r04y1j22	305	45	,	,	,
cord-023439-r04y1j22	305	46	University	University	NNP
cord-023439-r04y1j22	305	47	of	of	IN
cord-023439-r04y1j22	305	48	Aarhus	Aarhus	NNP
cord-023439-r04y1j22	305	49	,	,	,
cord-023439-r04y1j22	305	50	Aarhus	Aarhus	NNP
cord-023439-r04y1j22	305	51	,	,	,
cord-023439-r04y1j22	305	52	Denmark	Denmark	NNP
cord-023439-r04y1j22	305	53	.	.	.
cord-023439-r04y1j22	306	1	E	e	NN
cord-023439-r04y1j22	306	2	-	-	NN
cord-023439-r04y1j22	306	3	mail	mail	NN
cord-023439-r04y1j22	306	4	:	:	:
cord-023439-r04y1j22	307	1	rnsr@studmed.au.dk	rnsr@studmed.au.dk	NFP
cord-023439-r04y1j22	307	2	Materials	material	NNS
cord-023439-r04y1j22	307	3	and	and	CC
cord-023439-r04y1j22	307	4	methods	method	NNS
cord-023439-r04y1j22	307	5	:	:	:
cord-023439-r04y1j22	307	6	Isolated	isolated	JJ
cord-023439-r04y1j22	307	7	cryopreserved	cryopreserved	JJ
cord-023439-r04y1j22	307	8	human	human	JJ
cord-023439-r04y1j22	307	9	peripheral	peripheral	JJ
cord-023439-r04y1j22	307	10	blood	blood	NN
cord-023439-r04y1j22	307	11	mononuclear	mononuclear	NN
cord-023439-r04y1j22	307	12	cells	cell	NNS
cord-023439-r04y1j22	307	13	(	(	-LRB-
cord-023439-r04y1j22	307	14	PBMCs	pbmc	NNS
cord-023439-r04y1j22	307	15	)	)	-RRB-
cord-023439-r04y1j22	307	16	were	be	VBD
cord-023439-r04y1j22	307	17	stimulated	stimulate	VBN
cord-023439-r04y1j22	307	18	with	with	IN
cord-023439-r04y1j22	307	19	IL-2	IL-2	NNP
cord-023439-r04y1j22	307	20	and	and	CC
cord-023439-r04y1j22	307	21	IL-12	IL-12	NNP
cord-023439-r04y1j22	307	22	.	.	.
cord-023439-r04y1j22	308	1	This	this	DT
cord-023439-r04y1j22	308	2	stimulation	stimulation	NN
cord-023439-r04y1j22	308	3	has	have	VBZ
cord-023439-r04y1j22	308	4	previously	previously	RB
cord-023439-r04y1j22	308	5	been	be	VBN
cord-023439-r04y1j22	308	6	shown	show	VBN
cord-023439-r04y1j22	308	7	to	to	TO
cord-023439-r04y1j22	308	8	activate	activate	VB
cord-023439-r04y1j22	308	9	NK	NK	NNP
cord-023439-r04y1j22	308	10	cells	cell	NNS
cord-023439-r04y1j22	308	11	.	.	.
cord-023439-r04y1j22	309	1	Cell	cell	NN
cord-023439-r04y1j22	309	2	cytotoxicity	cytotoxicity	NN
cord-023439-r04y1j22	309	3	was	be	VBD
cord-023439-r04y1j22	309	4	measured	measure	VBN
cord-023439-r04y1j22	309	5	by	by	IN
cord-023439-r04y1j22	309	6	flow	flow	NN
cord-023439-r04y1j22	309	7	cytometry	cytometry	NN
cord-023439-r04y1j22	309	8	after	after	IN
cord-023439-r04y1j22	309	9	incubation	incubation	NN
cord-023439-r04y1j22	309	10	with	with	IN
cord-023439-r04y1j22	309	11	k562	k562	NN
cord-023439-r04y1j22	309	12	cells	cell	NNS
cord-023439-r04y1j22	309	13	.	.	.
cord-023439-r04y1j22	310	1	This	this	DT
cord-023439-r04y1j22	310	2	method	method	NN
cord-023439-r04y1j22	310	3	was	be	VBD
cord-023439-r04y1j22	310	4	compared	compare	VBN
cord-023439-r04y1j22	310	5	to	to	IN
cord-023439-r04y1j22	310	6	the	the	DT
cord-023439-r04y1j22	310	7	current	current	JJ
cord-023439-r04y1j22	310	8	standard	standard	JJ
cord-023439-r04y1j22	310	9	51Cr	51cr	CD
cord-023439-r04y1j22	310	10	release	release	NN
cord-023439-r04y1j22	310	11	assay	assay	NN
cord-023439-r04y1j22	310	12	.	.	.
cord-023439-r04y1j22	311	1	Cells	cell	NNS
cord-023439-r04y1j22	311	2	were	be	VBD
cord-023439-r04y1j22	311	3	treated	treat	VBN
cord-023439-r04y1j22	311	4	with	with	IN
cord-023439-r04y1j22	311	5	BFA	BFA	NNP
cord-023439-r04y1j22	311	6	to	to	TO
cord-023439-r04y1j22	311	7	accumulate	accumulate	VB
cord-023439-r04y1j22	311	8	IFN	IFN	NNP
cord-023439-r04y1j22	311	9	-	-	HYPH
cord-023439-r04y1j22	311	10	g	g	NNP
cord-023439-r04y1j22	311	11	,	,	,
cord-023439-r04y1j22	311	12	stained	stain	VBN
cord-023439-r04y1j22	311	13	for	for	IN
cord-023439-r04y1j22	311	14	surface	surface	NN
cord-023439-r04y1j22	311	15	markers	marker	NNS
cord-023439-r04y1j22	311	16	,	,	,
cord-023439-r04y1j22	311	17	permeabilized	permeabilized	JJ
cord-023439-r04y1j22	311	18	and	and	CC
cord-023439-r04y1j22	311	19	stained	stain	VBN
cord-023439-r04y1j22	311	20	for	for	IN
cord-023439-r04y1j22	311	21	intracellular	intracellular	JJ
cord-023439-r04y1j22	311	22	IFN	IFN	NNP
cord-023439-r04y1j22	311	23	-	-	HYPH
cord-023439-r04y1j22	311	24	g	g	NNP
cord-023439-r04y1j22	311	25	.	.	.
cord-023439-r04y1j22	312	1	Flow	flow	NN
cord-023439-r04y1j22	312	2	cytometry	cytometry	NN
cord-023439-r04y1j22	312	3	was	be	VBD
cord-023439-r04y1j22	312	4	then	then	RB
cord-023439-r04y1j22	312	5	performed	perform	VBN
cord-023439-r04y1j22	312	6	to	to	TO
cord-023439-r04y1j22	312	7	measure	measure	VB
cord-023439-r04y1j22	312	8	intracellular	intracellular	JJ
cord-023439-r04y1j22	312	9	IFN	IFN	NNP
cord-023439-r04y1j22	312	10	-	-	HYPH
cord-023439-r04y1j22	312	11	g	g	NN
cord-023439-r04y1j22	312	12	production	production	NN
cord-023439-r04y1j22	312	13	in	in	IN
cord-023439-r04y1j22	312	14	PBMC	PBMC	NNP
cord-023439-r04y1j22	312	15	,	,	,
cord-023439-r04y1j22	312	16	especially	especially	RB
cord-023439-r04y1j22	312	17	in	in	IN
cord-023439-r04y1j22	312	18	NK	NK	NNP
cord-023439-r04y1j22	312	19	cells	cell	NNS
cord-023439-r04y1j22	312	20	.	.	.
cord-023439-r04y1j22	313	1	Results	result	NNS
cord-023439-r04y1j22	313	2	:	:	:
cord-023439-r04y1j22	314	1	We	-PRON-	PRP
cord-023439-r04y1j22	314	2	have	have	VBP
cord-023439-r04y1j22	314	3	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	314	4	that	that	IN
cord-023439-r04y1j22	314	5	stimulation	stimulation	NN
cord-023439-r04y1j22	314	6	with	with	IN
cord-023439-r04y1j22	314	7	IL-2	IL-2	NNP
cord-023439-r04y1j22	314	8	and	and	CC
cord-023439-r04y1j22	314	9	IL-12	IL-12	NNP
cord-023439-r04y1j22	314	10	is	be	VBZ
cord-023439-r04y1j22	314	11	effective	effective	JJ
cord-023439-r04y1j22	314	12	in	in	IN
cord-023439-r04y1j22	314	13	increasing	increase	VBG
cord-023439-r04y1j22	314	14	the	the	DT
cord-023439-r04y1j22	314	15	number	number	NN
cord-023439-r04y1j22	314	16	of	of	IN
cord-023439-r04y1j22	314	17	IFN	IFN	NNP
cord-023439-r04y1j22	314	18	-	-	HYPH
cord-023439-r04y1j22	314	19	gpositive	gpositive	NN
cord-023439-r04y1j22	314	20	cells	cell	NNS
cord-023439-r04y1j22	314	21	.	.	.
cord-023439-r04y1j22	315	1	There	there	EX
cord-023439-r04y1j22	315	2	is	be	VBZ
cord-023439-r04y1j22	315	3	a	a	DT
cord-023439-r04y1j22	315	4	distinct	distinct	JJ
cord-023439-r04y1j22	315	5	difference	difference	NN
cord-023439-r04y1j22	315	6	between	between	IN
cord-023439-r04y1j22	315	7	the	the	DT
cord-023439-r04y1j22	315	8	CD3-CD56dim	CD3-CD56dim	NNP
cord-023439-r04y1j22	315	9	and	and	CC
cord-023439-r04y1j22	315	10	the	the	DT
cord-023439-r04y1j22	315	11	CD3-CD56bright	cd3-cd56bright	NN
cord-023439-r04y1j22	315	12	subsets	subset	NNS
cord-023439-r04y1j22	315	13	,	,	,
cord-023439-r04y1j22	315	14	with	with	IN
cord-023439-r04y1j22	315	15	a	a	DT
cord-023439-r04y1j22	315	16	much	much	RB
cord-023439-r04y1j22	315	17	greater	great	JJR
cord-023439-r04y1j22	315	18	proportion	proportion	NN
cord-023439-r04y1j22	315	19	of	of	IN
cord-023439-r04y1j22	315	20	IFN	IFN	NNP
cord-023439-r04y1j22	315	21	-	-	HYPH
cord-023439-r04y1j22	315	22	g	g	NN
cord-023439-r04y1j22	315	23	-	-	HYPH
cord-023439-r04y1j22	315	24	positive	positive	JJ
cord-023439-r04y1j22	315	25	cells	cell	NNS
cord-023439-r04y1j22	315	26	in	in	IN
cord-023439-r04y1j22	315	27	the	the	DT
cord-023439-r04y1j22	315	28	CD3-CD56bright	cd3-cd56bright	NN
cord-023439-r04y1j22	315	29	subset	subset	JJ
cord-023439-r04y1j22	315	30	.	.	.
cord-023439-r04y1j22	316	1	The	the	DT
cord-023439-r04y1j22	316	2	effects	effect	NNS
cord-023439-r04y1j22	316	3	of	of	IN
cord-023439-r04y1j22	316	4	stimulation	stimulation	NN
cord-023439-r04y1j22	316	5	with	with	IN
cord-023439-r04y1j22	316	6	IL-2	IL-2	NNP
cord-023439-r04y1j22	316	7	and	and	CC
cord-023439-r04y1j22	316	8	IL-12	IL-12	NNP
cord-023439-r04y1j22	316	9	on	on	IN
cord-023439-r04y1j22	316	10	cytotoxicity	cytotoxicity	NN
cord-023439-r04y1j22	316	11	will	will	MD
cord-023439-r04y1j22	316	12	be	be	VB
cord-023439-r04y1j22	316	13	presented	present	VBN
cord-023439-r04y1j22	316	14	,	,	,
cord-023439-r04y1j22	316	15	as	as	IN
cord-023439-r04y1j22	316	16	will	will	MD
cord-023439-r04y1j22	316	17	the	the	DT
cord-023439-r04y1j22	316	18	relation	relation	NN
cord-023439-r04y1j22	316	19	between	between	IN
cord-023439-r04y1j22	316	20	IFN	IFN	NNP
cord-023439-r04y1j22	316	21	-	-	HYPH
cord-023439-r04y1j22	316	22	g	g	NN
cord-023439-r04y1j22	316	23	production	production	NN
cord-023439-r04y1j22	316	24	and	and	CC
cord-023439-r04y1j22	316	25	cytotoxicity	cytotoxicity	NN
cord-023439-r04y1j22	316	26	.	.	.
cord-023439-r04y1j22	317	1	In	in	IN
cord-023439-r04y1j22	317	2	addition	addition	NN
cord-023439-r04y1j22	317	3	,	,	,
cord-023439-r04y1j22	317	4	we	-PRON-	PRP
cord-023439-r04y1j22	317	5	will	will	MD
cord-023439-r04y1j22	317	6	present	present	VB
cord-023439-r04y1j22	317	7	results	result	NNS
cord-023439-r04y1j22	317	8	of	of	IN
cord-023439-r04y1j22	317	9	these	these	DT
cord-023439-r04y1j22	317	10	assays	assay	NNS
cord-023439-r04y1j22	317	11	applied	apply	VBN
cord-023439-r04y1j22	317	12	to	to	IN
cord-023439-r04y1j22	317	13	porcine	porcine	JJ
cord-023439-r04y1j22	317	14	cells	cell	NNS
cord-023439-r04y1j22	317	15	.	.	.
cord-023439-r04y1j22	318	1	Discussion	discussion	NN
cord-023439-r04y1j22	318	2	:	:	:
cord-023439-r04y1j22	319	1	In	in	IN
cord-023439-r04y1j22	319	2	combination	combination	NN
cord-023439-r04y1j22	319	3	,	,	,
cord-023439-r04y1j22	319	4	these	these	DT
cord-023439-r04y1j22	319	5	tests	test	NNS
cord-023439-r04y1j22	319	6	will	will	MD
cord-023439-r04y1j22	319	7	address	address	VB
cord-023439-r04y1j22	319	8	NK	NK	NNP
cord-023439-r04y1j22	319	9	cell	cell	NN
cord-023439-r04y1j22	319	10	function	function	NN
cord-023439-r04y1j22	319	11	by	by	IN
cord-023439-r04y1j22	319	12	combining	combine	VBG
cord-023439-r04y1j22	319	13	cytotoxicity	cytotoxicity	NN
cord-023439-r04y1j22	319	14	with	with	IN
cord-023439-r04y1j22	319	15	IFN	IFN	NNP
cord-023439-r04y1j22	319	16	-	-	HYPH
cord-023439-r04y1j22	319	17	g	g	NN
cord-023439-r04y1j22	319	18	production	production	NN
cord-023439-r04y1j22	319	19	in	in	IN
cord-023439-r04y1j22	319	20	NK	NK	NNP
cord-023439-r04y1j22	319	21	cell	cell	NN
cord-023439-r04y1j22	319	22	subsets	subset	NNS
cord-023439-r04y1j22	319	23	.	.	.
cord-023439-r04y1j22	320	1	The	the	DT
cord-023439-r04y1j22	320	2	results	result	NNS
cord-023439-r04y1j22	320	3	will	will	MD
cord-023439-r04y1j22	320	4	demonstrate	demonstrate	VB
cord-023439-r04y1j22	320	5	whether	whether	IN
cord-023439-r04y1j22	320	6	this	this	DT
cord-023439-r04y1j22	320	7	could	could	MD
cord-023439-r04y1j22	320	8	serve	serve	VB
cord-023439-r04y1j22	320	9	as	as	IN
cord-023439-r04y1j22	320	10	a	a	DT
cord-023439-r04y1j22	320	11	useful	useful	JJ
cord-023439-r04y1j22	320	12	tool	tool	NN
cord-023439-r04y1j22	320	13	in	in	IN
cord-023439-r04y1j22	320	14	describing	describe	VBG
cord-023439-r04y1j22	320	15	NKcell	NKcell	NNP
cord-023439-r04y1j22	320	16	function	function	NN
cord-023439-r04y1j22	320	17	,	,	,
cord-023439-r04y1j22	320	18	which	which	WDT
cord-023439-r04y1j22	320	19	could	could	MD
cord-023439-r04y1j22	320	20	be	be	VB
cord-023439-r04y1j22	320	21	of	of	IN
cord-023439-r04y1j22	320	22	value	value	NN
cord-023439-r04y1j22	320	23	in	in	IN
cord-023439-r04y1j22	320	24	clinical	clinical	JJ
cord-023439-r04y1j22	320	25	and	and	CC
cord-023439-r04y1j22	320	26	experimental	experimental	JJ
cord-023439-r04y1j22	320	27	settings	setting	NNS
cord-023439-r04y1j22	320	28	.	.	.
cord-023439-r04y1j22	321	1	Culture	culture	NN
cord-023439-r04y1j22	321	2	of	of	IN
cord-023439-r04y1j22	321	3	Regulatory	Regulatory	NNP
cord-023439-r04y1j22	321	4	T	T	NNP
cord-023439-r04y1j22	321	5	-	-	HYPH
cord-023439-r04y1j22	321	6	Cell	cell	NN
cord-023439-r04y1j22	321	7	Lines	line	NNS
cord-023439-r04y1j22	321	8	from	from	IN
cord-023439-r04y1j22	321	9	Bronchial	Bronchial	NNP
cord-023439-r04y1j22	321	10	Mucosa	Mucosa	NNP
cord-023439-r04y1j22	321	11	T	T	NNP
cord-023439-r04y1j22	321	12	lymphocytes	lymphocyte	NNS
cord-023439-r04y1j22	321	13	play	play	VBP
cord-023439-r04y1j22	321	14	a	a	DT
cord-023439-r04y1j22	321	15	major	major	JJ
cord-023439-r04y1j22	321	16	role	role	NN
cord-023439-r04y1j22	321	17	in	in	IN
cord-023439-r04y1j22	321	18	many	many	JJ
cord-023439-r04y1j22	321	19	immune	immune	JJ
cord-023439-r04y1j22	321	20	responses	response	NNS
cord-023439-r04y1j22	321	21	.	.	.
cord-023439-r04y1j22	322	1	In	in	IN
cord-023439-r04y1j22	322	2	the	the	DT
cord-023439-r04y1j22	322	3	last	last	JJ
cord-023439-r04y1j22	322	4	decade	decade	NN
cord-023439-r04y1j22	322	5	,	,	,
cord-023439-r04y1j22	322	6	special	special	JJ
cord-023439-r04y1j22	322	7	focus	focus	NN
cord-023439-r04y1j22	322	8	has	have	VBZ
cord-023439-r04y1j22	322	9	been	be	VBN
cord-023439-r04y1j22	322	10	on	on	IN
cord-023439-r04y1j22	322	11	the	the	DT
cord-023439-r04y1j22	322	12	function	function	NN
cord-023439-r04y1j22	322	13	of	of	IN
cord-023439-r04y1j22	322	14	Th1	th1	NN
cord-023439-r04y1j22	322	15	and	and	CC
cord-023439-r04y1j22	322	16	Th2	th2	CD
cord-023439-r04y1j22	322	17	effector	effector	NN
cord-023439-r04y1j22	322	18	cells	cell	NNS
cord-023439-r04y1j22	322	19	.	.	.
cord-023439-r04y1j22	323	1	Now	now	RB
cord-023439-r04y1j22	323	2	the	the	DT
cord-023439-r04y1j22	323	3	importance	importance	NN
cord-023439-r04y1j22	323	4	of	of	IN
cord-023439-r04y1j22	323	5	regulatory	regulatory	JJ
cord-023439-r04y1j22	323	6	CD4	CD4	NNP
cord-023439-r04y1j22	323	7	þ	þ	NNP
cord-023439-r04y1j22	323	8	CD25	CD25	NNP
cord-023439-r04y1j22	323	9	þ	þ	NNP
cord-023439-r04y1j22	323	10	T	t	NN
cord-023439-r04y1j22	323	11	cells	cell	NNS
cord-023439-r04y1j22	323	12	in	in	IN
cord-023439-r04y1j22	323	13	maintenance	maintenance	NN
cord-023439-r04y1j22	323	14	of	of	IN
cord-023439-r04y1j22	323	15	the	the	DT
cord-023439-r04y1j22	323	16	immunological	immunological	JJ
cord-023439-r04y1j22	323	17	homeostasis	homeostasis	NN
cord-023439-r04y1j22	323	18	emerges	emerge	VBZ
cord-023439-r04y1j22	323	19	.	.	.
cord-023439-r04y1j22	324	1	Sarcoidosis	sarcoidosis	NN
cord-023439-r04y1j22	324	2	is	be	VBZ
cord-023439-r04y1j22	324	3	a	a	DT
cord-023439-r04y1j22	324	4	multisystem	multisystem	JJ
cord-023439-r04y1j22	324	5	granulomatous	granulomatous	JJ
cord-023439-r04y1j22	324	6	disorder	disorder	NN
cord-023439-r04y1j22	324	7	often	often	RB
cord-023439-r04y1j22	324	8	affecting	affect	VBG
cord-023439-r04y1j22	324	9	the	the	DT
cord-023439-r04y1j22	324	10	lungs	lung	NNS
cord-023439-r04y1j22	324	11	.	.	.
cord-023439-r04y1j22	325	1	The	the	DT
cord-023439-r04y1j22	325	2	typical	typical	JJ
cord-023439-r04y1j22	325	3	sarcoid	sarcoid	NN
cord-023439-r04y1j22	325	4	granulomas	granuloma	NNS
cord-023439-r04y1j22	325	5	consists	consist	VBZ
cord-023439-r04y1j22	325	6	of	of	IN
cord-023439-r04y1j22	325	7	epitheloid	epitheloid	NNP
cord-023439-r04y1j22	325	8	cells	cell	NNS
cord-023439-r04y1j22	325	9	,	,	,
cord-023439-r04y1j22	325	10	macrophages	macrophage	NNS
cord-023439-r04y1j22	325	11	and	and	CC
cord-023439-r04y1j22	325	12	lymphocytes	lymphocyte	NNS
cord-023439-r04y1j22	325	13	,	,	,
cord-023439-r04y1j22	325	14	mainly	mainly	RB
cord-023439-r04y1j22	325	15	CD4	CD4	NNP
cord-023439-r04y1j22	325	16	þ	þ	NNP
cord-023439-r04y1j22	325	17	T	T	NNP
cord-023439-r04y1j22	325	18	cells	cell	NNS
cord-023439-r04y1j22	325	19	of	of	IN
cord-023439-r04y1j22	325	20	Th1	th1	CD
cord-023439-r04y1j22	325	21	phenotype	phenotype	NN
cord-023439-r04y1j22	325	22	.	.	.
cord-023439-r04y1j22	326	1	We	-PRON-	PRP
cord-023439-r04y1j22	326	2	have	have	VBP
cord-023439-r04y1j22	326	3	cultured	culture	VBN
cord-023439-r04y1j22	326	4	T	t	NN
cord-023439-r04y1j22	326	5	cells	cell	NNS
cord-023439-r04y1j22	326	6	from	from	IN
cord-023439-r04y1j22	326	7	bronchial	bronchial	JJ
cord-023439-r04y1j22	326	8	biopsies	biopsy	NNS
cord-023439-r04y1j22	326	9	of	of	IN
cord-023439-r04y1j22	326	10	patients	patient	NNS
cord-023439-r04y1j22	326	11	with	with	IN
cord-023439-r04y1j22	326	12	sarcoidosis	sarcoidosi	NNS
cord-023439-r04y1j22	326	13	as	as	RB
cord-023439-r04y1j22	326	14	well	well	RB
cord-023439-r04y1j22	326	15	as	as	IN
cord-023439-r04y1j22	326	16	from	from	IN
cord-023439-r04y1j22	326	17	controls	control	NNS
cord-023439-r04y1j22	326	18	in	in	IN
cord-023439-r04y1j22	326	19	high	high	JJ
cord-023439-r04y1j22	326	20	levels	level	NNS
cord-023439-r04y1j22	326	21	of	of	IN
cord-023439-r04y1j22	326	22	interleukin	interleukin	NN
cord-023439-r04y1j22	326	23	2	2	CD
cord-023439-r04y1j22	326	24	(	(	-LRB-
cord-023439-r04y1j22	326	25	IL-2	IL-2	NNP
cord-023439-r04y1j22	326	26	)	)	-RRB-
cord-023439-r04y1j22	326	27	and	and	CC
cord-023439-r04y1j22	326	28	IL-4	IL-4	NNP
cord-023439-r04y1j22	326	29	and	and	CC
cord-023439-r04y1j22	326	30	demonstrate	demonstrate	VB
cord-023439-r04y1j22	326	31	spontaneously	spontaneously	RB
cord-023439-r04y1j22	326	32	arising	arise	VBG
cord-023439-r04y1j22	326	33	CD4	CD4	NNP
cord-023439-r04y1j22	326	34	þ	þ	NNP
cord-023439-r04y1j22	326	35	CD25	CD25	NNP
cord-023439-r04y1j22	326	36	þ	þ	NNP
cord-023439-r04y1j22	326	37	populations	population	NNS
cord-023439-r04y1j22	326	38	and	and	CC
cord-023439-r04y1j22	326	39	high	high	JJ
cord-023439-r04y1j22	326	40	concentrations	concentration	NNS
cord-023439-r04y1j22	326	41	of	of	IN
cord-023439-r04y1j22	326	42	IL-10	IL-10	NNP
cord-023439-r04y1j22	326	43	in	in	IN
cord-023439-r04y1j22	326	44	these	these	DT
cord-023439-r04y1j22	326	45	cultures	culture	NNS
cord-023439-r04y1j22	326	46	.	.	.
cord-023439-r04y1j22	327	1	The	the	DT
cord-023439-r04y1j22	327	2	main	main	JJ
cord-023439-r04y1j22	327	3	difference	difference	NN
cord-023439-r04y1j22	327	4	between	between	IN
cord-023439-r04y1j22	327	5	cultures	culture	NNS
cord-023439-r04y1j22	327	6	of	of	IN
cord-023439-r04y1j22	327	7	sarcoid	sarcoid	NNP
cord-023439-r04y1j22	327	8	origin	origin	NN
cord-023439-r04y1j22	327	9	compared	compare	VBN
cord-023439-r04y1j22	327	10	to	to	IN
cord-023439-r04y1j22	327	11	controls	control	NNS
cord-023439-r04y1j22	327	12	is	be	VBZ
cord-023439-r04y1j22	327	13	a	a	DT
cord-023439-r04y1j22	327	14	very	very	RB
cord-023439-r04y1j22	327	15	much	much	RB
cord-023439-r04y1j22	327	16	higher	high	JJR
cord-023439-r04y1j22	327	17	concentration	concentration	NN
cord-023439-r04y1j22	327	18	of	of	IN
cord-023439-r04y1j22	327	19	the	the	DT
cord-023439-r04y1j22	327	20	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	327	21	cytokines	cytokine	NNS
cord-023439-r04y1j22	327	22	IL-6	IL-6	NNP
cord-023439-r04y1j22	327	23	and	and	CC
cord-023439-r04y1j22	327	24	TNF	TNF	NNP
cord-023439-r04y1j22	327	25	-	-	,
cord-023439-r04y1j22	327	26	a	a	NN
cord-023439-r04y1j22	327	27	in	in	IN
cord-023439-r04y1j22	327	28	cultures	culture	NNS
cord-023439-r04y1j22	327	29	of	of	IN
cord-023439-r04y1j22	327	30	sarcoid	sarcoid	NNP
cord-023439-r04y1j22	327	31	origin	origin	NN
cord-023439-r04y1j22	327	32	.	.	.
cord-023439-r04y1j22	328	1	The	the	DT
cord-023439-r04y1j22	328	2	Effects	effect	NNS
cord-023439-r04y1j22	328	3	of	of	IN
cord-023439-r04y1j22	328	4	Hyperbaric	Hyperbaric	NNP
cord-023439-r04y1j22	328	5	Exposure	Exposure	NNP
cord-023439-r04y1j22	328	6	on	on	IN
cord-023439-r04y1j22	328	7	Human	Human	NNP
cord-023439-r04y1j22	328	8	Peripheral	Peripheral	NNP
cord-023439-r04y1j22	328	9	Blood	Blood	NNP
cord-023439-r04y1j22	328	10	Mononuclear	Mononuclear	NNP
cord-023439-r04y1j22	328	11	Cells	Cells	NNPS
cord-023439-r04y1j22	328	12	,	,	,
cord-023439-r04y1j22	328	13	with	with	IN
cord-023439-r04y1j22	328	14	Special	Special	NNP
cord-023439-r04y1j22	328	15	Emphasis	Emphasis	NNP
cord-023439-r04y1j22	328	16	on	on	IN
cord-023439-r04y1j22	328	17	Natural	Natural	NNP
cord-023439-r04y1j22	328	18	Killer	Killer	NNP
cord-023439-r04y1j22	328	19	Cell	Cell	NNP
cord-023439-r04y1j22	328	20	Cytotoxicity	Cytotoxicity	NNP
cord-023439-r04y1j22	328	21	and	and	CC
cord-023439-r04y1j22	328	22	Subsets	Subsets	NNPS
cord-023439-r04y1j22	328	23	Materials	material	NNS
cord-023439-r04y1j22	328	24	and	and	CC
cord-023439-r04y1j22	328	25	methods	method	NNS
cord-023439-r04y1j22	328	26	:	:	:
cord-023439-r04y1j22	329	1	As	as	IN
cord-023439-r04y1j22	329	2	an	an	DT
cord-023439-r04y1j22	329	3	experimental	experimental	JJ
cord-023439-r04y1j22	329	4	physiological	physiological	JJ
cord-023439-r04y1j22	329	5	stress	stress	NN
cord-023439-r04y1j22	329	6	model	model	NN
cord-023439-r04y1j22	329	7	,	,	,
cord-023439-r04y1j22	329	8	we	-PRON-	PRP
cord-023439-r04y1j22	329	9	examined	examine	VBD
cord-023439-r04y1j22	329	10	the	the	DT
cord-023439-r04y1j22	329	11	effects	effect	NNS
cord-023439-r04y1j22	329	12	of	of	IN
cord-023439-r04y1j22	329	13	hyperbaric	hyperbaric	NN
cord-023439-r04y1j22	329	14	exposure	exposure	NN
cord-023439-r04y1j22	329	15	on	on	IN
cord-023439-r04y1j22	329	16	peripheral	peripheral	JJ
cord-023439-r04y1j22	329	17	blood	blood	NN
cord-023439-r04y1j22	329	18	mononuclear	mononuclear	NN
cord-023439-r04y1j22	329	19	cells	cell	NNS
cord-023439-r04y1j22	329	20	(	(	-LRB-
cord-023439-r04y1j22	329	21	PBMCs	pbmc	NNS
cord-023439-r04y1j22	329	22	)	)	-RRB-
cord-023439-r04y1j22	329	23	obtained	obtain	VBN
cord-023439-r04y1j22	329	24	from	from	IN
cord-023439-r04y1j22	329	25	venous	venous	JJ
cord-023439-r04y1j22	329	26	blood	blood	NN
cord-023439-r04y1j22	329	27	drawn	draw	VBN
cord-023439-r04y1j22	329	28	from	from	IN
cord-023439-r04y1j22	329	29	eight	eight	CD
cord-023439-r04y1j22	329	30	divers	diver	NNS
cord-023439-r04y1j22	329	31	during	during	IN
cord-023439-r04y1j22	329	32	a	a	DT
cord-023439-r04y1j22	329	33	simulated	simulate	VBN
cord-023439-r04y1j22	329	34	heliox	heliox	NN
cord-023439-r04y1j22	329	35	saturation	saturation	NN
cord-023439-r04y1j22	329	36	dive	dive	NN
cord-023439-r04y1j22	329	37	.	.	.
cord-023439-r04y1j22	330	1	Eight	eight	CD
cord-023439-r04y1j22	330	2	persons	person	NNS
cord-023439-r04y1j22	330	3	working	work	VBG
cord-023439-r04y1j22	330	4	in	in	IN
cord-023439-r04y1j22	330	5	normobar	normobar	NNP
cord-023439-r04y1j22	330	6	atmosphere	atmosphere	NN
cord-023439-r04y1j22	330	7	outside	outside	IN
cord-023439-r04y1j22	330	8	the	the	DT
cord-023439-r04y1j22	330	9	pressurized	pressurize	VBN
cord-023439-r04y1j22	330	10	chamber	chamber	NN
cord-023439-r04y1j22	330	11	served	serve	VBD
cord-023439-r04y1j22	330	12	as	as	IN
cord-023439-r04y1j22	330	13	control	control	NN
cord-023439-r04y1j22	330	14	donors	donor	NNS
cord-023439-r04y1j22	330	15	.	.	.
cord-023439-r04y1j22	331	1	The	the	DT
cord-023439-r04y1j22	331	2	spontaneous	spontaneous	JJ
cord-023439-r04y1j22	331	3	cytotoxicity	cytotoxicity	NN
cord-023439-r04y1j22	331	4	of	of	IN
cord-023439-r04y1j22	331	5	the	the	DT
cord-023439-r04y1j22	331	6	PBMCs	pbmc	NNS
cord-023439-r04y1j22	331	7	was	be	VBD
cord-023439-r04y1j22	331	8	estimated	estimate	VBN
cord-023439-r04y1j22	331	9	in	in	IN
cord-023439-r04y1j22	331	10	a	a	DT
cord-023439-r04y1j22	331	11	4	4	CD
cord-023439-r04y1j22	331	12	h	h	NN
cord-023439-r04y1j22	331	13	51Cr	51cr	CD
cord-023439-r04y1j22	331	14	-	-	HYPH
cord-023439-r04y1j22	331	15	release	release	NN
cord-023439-r04y1j22	331	16	assay	assay	NN
cord-023439-r04y1j22	331	17	using	use	VBG
cord-023439-r04y1j22	331	18	k562	k562	NNP
cord-023439-r04y1j22	331	19	as	as	IN
cord-023439-r04y1j22	331	20	NK	nk	NN
cord-023439-r04y1j22	331	21	-	-	HYPH
cord-023439-r04y1j22	331	22	sensitive	sensitive	JJ
cord-023439-r04y1j22	331	23	target	target	NN
cord-023439-r04y1j22	331	24	cells	cell	NNS
cord-023439-r04y1j22	331	25	.	.	.
cord-023439-r04y1j22	332	1	The	the	DT
cord-023439-r04y1j22	332	2	PBMCs	pbmc	NNS
cord-023439-r04y1j22	332	3	were	be	VBD
cord-023439-r04y1j22	332	4	characterized	characterize	VBN
cord-023439-r04y1j22	332	5	,	,	,
cord-023439-r04y1j22	332	6	using	use	VBG
cord-023439-r04y1j22	332	7	4-colour	4-colour	CD
cord-023439-r04y1j22	332	8	flow	flow	NN
cord-023439-r04y1j22	332	9	cytometry	cytometry	NN
cord-023439-r04y1j22	332	10	,	,	,
cord-023439-r04y1j22	332	11	with	with	IN
cord-023439-r04y1j22	332	12	special	special	JJ
cord-023439-r04y1j22	332	13	emphasis	emphasis	NN
cord-023439-r04y1j22	332	14	on	on	IN
cord-023439-r04y1j22	332	15	the	the	DT
cord-023439-r04y1j22	332	16	NK	nk	NN
cord-023439-r04y1j22	332	17	-	-	HYPH
cord-023439-r04y1j22	332	18	cell	cell	NN
cord-023439-r04y1j22	332	19	subsets	subset	NNS
cord-023439-r04y1j22	332	20	.	.	.
cord-023439-r04y1j22	333	1	The	the	DT
cord-023439-r04y1j22	333	2	data	datum	NNS
cord-023439-r04y1j22	333	3	were	be	VBD
cord-023439-r04y1j22	333	4	statistically	statistically	RB
cord-023439-r04y1j22	333	5	analysed	analyse	VBN
cord-023439-r04y1j22	333	6	using	use	VBG
cord-023439-r04y1j22	333	7	a	a	DT
cord-023439-r04y1j22	333	8	multivariate	multivariate	JJ
cord-023439-r04y1j22	333	9	regression	regression	NN
cord-023439-r04y1j22	333	10	model	model	NN
cord-023439-r04y1j22	333	11	(	(	-LRB-
cord-023439-r04y1j22	333	12	Stata	Stata	NNP
cord-023439-r04y1j22	333	13	8.2	8.2	CD
cord-023439-r04y1j22	333	14	)	)	-RRB-
cord-023439-r04y1j22	333	15	.	.	.
cord-023439-r04y1j22	334	1	P	p	NN
cord-023439-r04y1j22	334	2	values	value	NNS
cord-023439-r04y1j22	334	3	<	<	XX
cord-023439-r04y1j22	334	4	0.05	0.05	CD
cord-023439-r04y1j22	334	5	was	be	VBD
cord-023439-r04y1j22	334	6	considered	consider	VBN
cord-023439-r04y1j22	334	7	statistically	statistically	RB
cord-023439-r04y1j22	334	8	significant	significant	JJ
cord-023439-r04y1j22	334	9	.	.	.
cord-023439-r04y1j22	335	1	Results	result	NNS
cord-023439-r04y1j22	335	2	:	:	:
cord-023439-r04y1j22	336	1	The	the	DT
cord-023439-r04y1j22	336	2	estimated	estimate	VBN
cord-023439-r04y1j22	336	3	cytotoxicity	cytotoxicity	NN
cord-023439-r04y1j22	336	4	increased	increase	VBD
cord-023439-r04y1j22	336	5	significantly	significantly	RB
cord-023439-r04y1j22	336	6	in	in	IN
cord-023439-r04y1j22	336	7	both	both	CC
cord-023439-r04y1j22	336	8	the	the	DT
cord-023439-r04y1j22	336	9	group	group	NN
cord-023439-r04y1j22	336	10	of	of	IN
cord-023439-r04y1j22	336	11	divers	diver	NNS
cord-023439-r04y1j22	336	12	and	and	CC
cord-023439-r04y1j22	336	13	control	control	VB
cord-023439-r04y1j22	336	14	donors	donor	NNS
cord-023439-r04y1j22	336	15	during	during	IN
cord-023439-r04y1j22	336	16	the	the	DT
cord-023439-r04y1j22	336	17	dive	dive	NN
cord-023439-r04y1j22	336	18	(	(	-LRB-
cord-023439-r04y1j22	336	19	pdivers	pdivers	NNP
cord-023439-r04y1j22	336	20	<	<	XX
cord-023439-r04y1j22	336	21	0.01	0.01	CD
cord-023439-r04y1j22	336	22	and	and	CC
cord-023439-r04y1j22	336	23	pcontrols	pcontrols	NNP
cord-023439-r04y1j22	336	24	<	<	XX
cord-023439-r04y1j22	336	25	0.01	0.01	CD
cord-023439-r04y1j22	336	26	)	)	-RRB-
cord-023439-r04y1j22	336	27	.	.	.
cord-023439-r04y1j22	337	1	Although	although	IN
cord-023439-r04y1j22	337	2	the	the	DT
cord-023439-r04y1j22	337	3	cytotoxicity	cytotoxicity	NN
cord-023439-r04y1j22	337	4	increased	increase	VBD
cord-023439-r04y1j22	337	5	relatively	relatively	RB
cord-023439-r04y1j22	337	6	more	more	RBR
cord-023439-r04y1j22	337	7	(	(	-LRB-
cord-023439-r04y1j22	337	8	P	p	NN
cord-023439-r04y1j22	337	9	<	<	XX
cord-023439-r04y1j22	337	10	0.01	0.01	CD
cord-023439-r04y1j22	337	11	)	)	-RRB-
cord-023439-r04y1j22	337	12	in	in	IN
cord-023439-r04y1j22	337	13	the	the	DT
cord-023439-r04y1j22	337	14	group	group	NN
cord-023439-r04y1j22	337	15	of	of	IN
cord-023439-r04y1j22	337	16	divers	diver	NNS
cord-023439-r04y1j22	337	17	compared	compare	VBN
cord-023439-r04y1j22	337	18	to	to	IN
cord-023439-r04y1j22	337	19	the	the	DT
cord-023439-r04y1j22	337	20	group	group	NN
cord-023439-r04y1j22	337	21	of	of	IN
cord-023439-r04y1j22	337	22	control	control	NN
cord-023439-r04y1j22	337	23	donors	donor	NNS
cord-023439-r04y1j22	337	24	between	between	IN
cord-023439-r04y1j22	337	25	day	day	NN
cord-023439-r04y1j22	337	26	1	1	CD
cord-023439-r04y1j22	337	27	and	and	CC
cord-023439-r04y1j22	337	28	2	2	CD
cord-023439-r04y1j22	337	29	.	.	.
cord-023439-r04y1j22	338	1	Discussion	discussion	NN
cord-023439-r04y1j22	338	2	:	:	:
cord-023439-r04y1j22	339	1	The	the	DT
cord-023439-r04y1j22	339	2	increased	increase	VBN
cord-023439-r04y1j22	339	3	cytotoxicity	cytotoxicity	NN
cord-023439-r04y1j22	339	4	of	of	IN
cord-023439-r04y1j22	339	5	PBMC	PBMC	NNP
cord-023439-r04y1j22	339	6	estimated	estimate	VBN
cord-023439-r04y1j22	339	7	in	in	IN
cord-023439-r04y1j22	339	8	the	the	DT
cord-023439-r04y1j22	339	9	group	group	NN
cord-023439-r04y1j22	339	10	of	of	IN
cord-023439-r04y1j22	339	11	divers	diver	NNS
cord-023439-r04y1j22	339	12	indicate	indicate	VBP
cord-023439-r04y1j22	339	13	that	that	IN
cord-023439-r04y1j22	339	14	parts	part	NNS
cord-023439-r04y1j22	339	15	of	of	IN
cord-023439-r04y1j22	339	16	the	the	DT
cord-023439-r04y1j22	339	17	cellular	cellular	JJ
cord-023439-r04y1j22	339	18	immune	immune	JJ
cord-023439-r04y1j22	339	19	system	system	NN
cord-023439-r04y1j22	339	20	are	be	VBP
cord-023439-r04y1j22	339	21	affected	affect	VBN
cord-023439-r04y1j22	339	22	during	during	IN
cord-023439-r04y1j22	339	23	the	the	DT
cord-023439-r04y1j22	339	24	extreme	extreme	JJ
cord-023439-r04y1j22	339	25	physiological	physiological	JJ
cord-023439-r04y1j22	339	26	conditions	condition	NNS
cord-023439-r04y1j22	339	27	induced	induce	VBN
cord-023439-r04y1j22	339	28	during	during	IN
cord-023439-r04y1j22	339	29	the	the	DT
cord-023439-r04y1j22	339	30	initial	initial	JJ
cord-023439-r04y1j22	339	31	phase	phase	NN
cord-023439-r04y1j22	339	32	of	of	IN
cord-023439-r04y1j22	339	33	the	the	DT
cord-023439-r04y1j22	339	34	presented	present	VBN
cord-023439-r04y1j22	339	35	experimental	experimental	JJ
cord-023439-r04y1j22	339	36	hyperbaric	hyperbaric	NN
cord-023439-r04y1j22	339	37	setup	setup	NN
cord-023439-r04y1j22	339	38	.	.	.
cord-023439-r04y1j22	340	1	The	the	DT
cord-023439-r04y1j22	340	2	increase	increase	NN
cord-023439-r04y1j22	340	3	in	in	IN
cord-023439-r04y1j22	340	4	cytotoxicity	cytotoxicity	NN
cord-023439-r04y1j22	340	5	observed	observe	VBN
cord-023439-r04y1j22	340	6	in	in	IN
cord-023439-r04y1j22	340	7	the	the	DT
cord-023439-r04y1j22	340	8	group	group	NN
cord-023439-r04y1j22	340	9	of	of	IN
cord-023439-r04y1j22	340	10	control	control	NN
cord-023439-r04y1j22	340	11	donors	donor	NNS
cord-023439-r04y1j22	340	12	could	could	MD
cord-023439-r04y1j22	340	13	hypothetically	hypothetically	RB
cord-023439-r04y1j22	340	14	reflect	reflect	VB
cord-023439-r04y1j22	340	15	the	the	DT
cord-023439-r04y1j22	340	16	stress	stress	NN
cord-023439-r04y1j22	340	17	level	level	NN
cord-023439-r04y1j22	340	18	in	in	IN
cord-023439-r04y1j22	340	19	persons	person	NNS
cord-023439-r04y1j22	340	20	working	work	VBG
cord-023439-r04y1j22	340	21	outside	outside	IN
cord-023439-r04y1j22	340	22	the	the	DT
cord-023439-r04y1j22	340	23	pressurized	pressurize	VBN
cord-023439-r04y1j22	340	24	chamber	chamber	NN
cord-023439-r04y1j22	340	25	during	during	IN
cord-023439-r04y1j22	340	26	the	the	DT
cord-023439-r04y1j22	340	27	dive	dive	NN
cord-023439-r04y1j22	340	28	.	.	.
cord-023439-r04y1j22	341	1	The	the	DT
cord-023439-r04y1j22	341	2	interaction	interaction	NN
cord-023439-r04y1j22	341	3	with	with	IN
cord-023439-r04y1j22	341	4	adhesion	adhesion	NN
cord-023439-r04y1j22	341	5	molecules	molecule	NNS
cord-023439-r04y1j22	341	6	expressed	express	VBN
cord-023439-r04y1j22	341	7	by	by	IN
cord-023439-r04y1j22	341	8	vascular	vascular	JJ
cord-023439-r04y1j22	341	9	endothelium	endothelium	NN
cord-023439-r04y1j22	341	10	is	be	VBZ
cord-023439-r04y1j22	341	11	the	the	DT
cord-023439-r04y1j22	341	12	first	first	JJ
cord-023439-r04y1j22	341	13	step	step	NN
cord-023439-r04y1j22	341	14	in	in	IN
cord-023439-r04y1j22	341	15	lymphocyte	lymphocyte	NN
cord-023439-r04y1j22	341	16	infiltration	infiltration	NN
cord-023439-r04y1j22	341	17	into	into	IN
cord-023439-r04y1j22	341	18	tissues	tissue	NNS
cord-023439-r04y1j22	341	19	.	.	.
cord-023439-r04y1j22	342	1	At	at	IN
cord-023439-r04y1j22	342	2	both	both	CC
cord-023439-r04y1j22	342	3	cutaneous	cutaneous	JJ
cord-023439-r04y1j22	342	4	and	and	CC
cord-023439-r04y1j22	342	5	mucosal	mucosal	JJ
cord-023439-r04y1j22	342	6	sites	site	NNS
cord-023439-r04y1j22	342	7	interleukin-10	interleukin-10	NN
cord-023439-r04y1j22	342	8	(	(	-LRB-
cord-023439-r04y1j22	342	9	IL-10	IL-10	NNP
cord-023439-r04y1j22	342	10	)	)	-RRB-
cord-023439-r04y1j22	342	11	,	,	,
cord-023439-r04y1j22	342	12	IL-12	IL-12	NNP
cord-023439-r04y1j22	342	13	and	and	CC
cord-023439-r04y1j22	342	14	transforming	transform	VBG
cord-023439-r04y1j22	342	15	growth	growth	NN
cord-023439-r04y1j22	342	16	factor	factor	NN
cord-023439-r04y1j22	342	17	(	(	-LRB-
cord-023439-r04y1j22	342	18	TGF)-b	TGF)-b	NNS
cord-023439-r04y1j22	342	19	are	be	VBP
cord-023439-r04y1j22	342	20	important	important	JJ
cord-023439-r04y1j22	342	21	regulators	regulator	NNS
cord-023439-r04y1j22	342	22	of	of	IN
cord-023439-r04y1j22	342	23	chronic	chronic	JJ
cord-023439-r04y1j22	342	24	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	342	25	disease	disease	NN
cord-023439-r04y1j22	342	26	,	,	,
cord-023439-r04y1j22	342	27	where	where	WRB
cord-023439-r04y1j22	342	28	cutaneous	cutaneous	JJ
cord-023439-r04y1j22	342	29	lymphocyteassociated	lymphocyteassociated	JJ
cord-023439-r04y1j22	342	30	antigen	antigen	NN
cord-023439-r04y1j22	342	31	(	(	-LRB-
cord-023439-r04y1j22	342	32	CLA	CLA	NNP
cord-023439-r04y1j22	342	33	)	)	-RRB-
cord-023439-r04y1j22	342	34	and	and	CC
cord-023439-r04y1j22	342	35	aE	ae	NN
cord-023439-r04y1j22	342	36	integrin	integrin	NNP
cord-023439-r04y1j22	342	37	(	(	-LRB-
cord-023439-r04y1j22	342	38	CD103	CD103	NNP
cord-023439-r04y1j22	342	39	)	)	-RRB-
cord-023439-r04y1j22	342	40	may	may	MD
cord-023439-r04y1j22	342	41	be	be	VB
cord-023439-r04y1j22	342	42	expressed	express	VBN
cord-023439-r04y1j22	342	43	.	.	.
cord-023439-r04y1j22	343	1	Unlike	unlike	IN
cord-023439-r04y1j22	343	2	CLA	CLA	NNP
cord-023439-r04y1j22	343	3	,	,	,
cord-023439-r04y1j22	343	4	CD103	CD103	NNP
cord-023439-r04y1j22	343	5	is	be	VBZ
cord-023439-r04y1j22	343	6	not	not	RB
cord-023439-r04y1j22	343	7	believed	believe	VBN
cord-023439-r04y1j22	343	8	to	to	TO
cord-023439-r04y1j22	343	9	play	play	VB
cord-023439-r04y1j22	343	10	a	a	DT
cord-023439-r04y1j22	343	11	role	role	NN
cord-023439-r04y1j22	343	12	in	in	IN
cord-023439-r04y1j22	343	13	tissue	tissue	NN
cord-023439-r04y1j22	343	14	-	-	HYPH
cord-023439-r04y1j22	343	15	specific	specific	JJ
cord-023439-r04y1j22	343	16	homing	homing	NN
cord-023439-r04y1j22	343	17	but	but	CC
cord-023439-r04y1j22	343	18	may	may	MD
cord-023439-r04y1j22	343	19	help	help	VB
cord-023439-r04y1j22	343	20	to	to	TO
cord-023439-r04y1j22	343	21	retain	retain	VB
cord-023439-r04y1j22	343	22	T	t	NN
cord-023439-r04y1j22	343	23	cells	cell	NNS
cord-023439-r04y1j22	343	24	within	within	IN
cord-023439-r04y1j22	343	25	epithelial	epithelial	JJ
cord-023439-r04y1j22	343	26	layers	layer	NNS
cord-023439-r04y1j22	343	27	.	.	.
cord-023439-r04y1j22	344	1	We	-PRON-	PRP
cord-023439-r04y1j22	344	2	have	have	VBP
cord-023439-r04y1j22	344	3	previously	previously	RB
cord-023439-r04y1j22	344	4	shown	show	VBN
cord-023439-r04y1j22	344	5	that	that	IN
cord-023439-r04y1j22	344	6	IL-12	IL-12	NNP
cord-023439-r04y1j22	344	7	alone	alone	RB
cord-023439-r04y1j22	344	8	can	can	MD
cord-023439-r04y1j22	344	9	together	together	RB
cord-023439-r04y1j22	344	10	with	with	IN
cord-023439-r04y1j22	344	11	an	an	DT
cord-023439-r04y1j22	344	12	unknown	unknown	JJ
cord-023439-r04y1j22	344	13	cofactor	cofactor	NN
cord-023439-r04y1j22	344	14	increase	increase	NN
cord-023439-r04y1j22	344	15	the	the	DT
cord-023439-r04y1j22	344	16	expression	expression	NN
cord-023439-r04y1j22	344	17	of	of	IN
cord-023439-r04y1j22	344	18	CLA	CLA	NNP
cord-023439-r04y1j22	344	19	.	.	.
cord-023439-r04y1j22	345	1	Stimulation	stimulation	NN
cord-023439-r04y1j22	345	2	with	with	IN
cord-023439-r04y1j22	345	3	streptococcal	streptococcal	JJ
cord-023439-r04y1j22	345	4	pyrogenic	pyrogenic	JJ
cord-023439-r04y1j22	345	5	exotoxin	exotoxin	NN
cord-023439-r04y1j22	345	6	C	C	NNP
cord-023439-r04y1j22	345	7	(	(	-LRB-
cord-023439-r04y1j22	345	8	SpeC	spec	NN
cord-023439-r04y1j22	345	9	)	)	-RRB-
cord-023439-r04y1j22	345	10	increased	increase	VBD
cord-023439-r04y1j22	345	11	the	the	DT
cord-023439-r04y1j22	345	12	expression	expression	NN
cord-023439-r04y1j22	345	13	of	of	IN
cord-023439-r04y1j22	345	14	CD103	CD103	NNP
cord-023439-r04y1j22	345	15	by	by	IN
cord-023439-r04y1j22	345	16	CD8	CD8	NNP
cord-023439-r04y1j22	345	17	þ	þ	NNP
cord-023439-r04y1j22	345	18	but	but	CC
cord-023439-r04y1j22	345	19	not	not	RB
cord-023439-r04y1j22	345	20	CD4	CD4	NNP
cord-023439-r04y1j22	345	21	þ	þ	NNP
cord-023439-r04y1j22	345	22	T	t	NN
cord-023439-r04y1j22	345	23	cells	cell	NNS
cord-023439-r04y1j22	345	24	.	.	.
cord-023439-r04y1j22	346	1	While	while	IN
cord-023439-r04y1j22	346	2	IL-12	IL-12	NNP
cord-023439-r04y1j22	346	3	increased	increase	VBD
cord-023439-r04y1j22	346	4	superantigen	superantigen	NN
cord-023439-r04y1j22	346	5	-	-	HYPH
cord-023439-r04y1j22	346	6	stimulated	stimulate	VBN
cord-023439-r04y1j22	346	7	expression	expression	NN
cord-023439-r04y1j22	346	8	of	of	IN
cord-023439-r04y1j22	346	9	CLA	CLA	NNP
cord-023439-r04y1j22	346	10	,	,	,
cord-023439-r04y1j22	346	11	this	this	DT
cord-023439-r04y1j22	346	12	cytokine	cytokine	NN
cord-023439-r04y1j22	346	13	strongly	strongly	RB
cord-023439-r04y1j22	346	14	inhibited	inhibit	VBD
cord-023439-r04y1j22	346	15	the	the	DT
cord-023439-r04y1j22	346	16	CD103	CD103	NNP
cord-023439-r04y1j22	346	17	expres	expres	NNP
cord-023439-r04y1j22	346	18	-	-	HYPH
cord-023439-r04y1j22	346	19	sion	sion	NNP
cord-023439-r04y1j22	346	20	,	,	,
cord-023439-r04y1j22	346	21	and	and	CC
cord-023439-r04y1j22	346	22	a	a	DT
cord-023439-r04y1j22	346	23	combination	combination	NN
cord-023439-r04y1j22	346	24	of	of	IN
cord-023439-r04y1j22	346	25	IL-12	IL-12	NNP
cord-023439-r04y1j22	346	26	and	and	CC
cord-023439-r04y1j22	346	27	TGF	TGF	NNP
cord-023439-r04y1j22	346	28	-	-	HYPH
cord-023439-r04y1j22	346	29	b	b	LS
cord-023439-r04y1j22	346	30	completely	completely	RB
cord-023439-r04y1j22	346	31	abrogated	abrogate	VBD
cord-023439-r04y1j22	346	32	the	the	DT
cord-023439-r04y1j22	346	33	induced	induce	VBN
cord-023439-r04y1j22	346	34	CD103	cd103	NN
cord-023439-r04y1j22	346	35	expression	expression	NN
cord-023439-r04y1j22	346	36	.	.	.
cord-023439-r04y1j22	347	1	Conversely	conversely	RB
cord-023439-r04y1j22	347	2	,	,	,
cord-023439-r04y1j22	347	3	IL-10	IL-10	NNP
cord-023439-r04y1j22	347	4	suppressed	suppress	VBD
cord-023439-r04y1j22	347	5	CLA	CLA	NNP
cord-023439-r04y1j22	347	6	but	but	CC
cord-023439-r04y1j22	347	7	increased	increase	VBD
cord-023439-r04y1j22	347	8	CD103	CD103	NNP
cord-023439-r04y1j22	347	9	expression	expression	NN
cord-023439-r04y1j22	347	10	.	.	.
cord-023439-r04y1j22	348	1	These	these	DT
cord-023439-r04y1j22	348	2	findings	finding	NNS
cord-023439-r04y1j22	348	3	indicate	indicate	VBP
cord-023439-r04y1j22	348	4	that	that	IN
cord-023439-r04y1j22	348	5	,	,	,
cord-023439-r04y1j22	348	6	in	in	IN
cord-023439-r04y1j22	348	7	addition	addition	NN
cord-023439-r04y1j22	348	8	to	to	IN
cord-023439-r04y1j22	348	9	suppressing	suppress	VBG
cord-023439-r04y1j22	348	10	the	the	DT
cord-023439-r04y1j22	348	11	development	development	NN
cord-023439-r04y1j22	348	12	of	of	IN
cord-023439-r04y1j22	348	13	Th1-mediated	Th1-mediated	NNP
cord-023439-r04y1j22	348	14	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	348	15	responses	response	NNS
cord-023439-r04y1j22	348	16	,	,	,
cord-023439-r04y1j22	348	17	IL-10	IL-10	NNP
cord-023439-r04y1j22	348	18	may	may	MD
cord-023439-r04y1j22	348	19	also	also	RB
cord-023439-r04y1j22	348	20	inhibit	inhibit	VB
cord-023439-r04y1j22	348	21	the	the	DT
cord-023439-r04y1j22	348	22	migration	migration	NN
cord-023439-r04y1j22	348	23	of	of	IN
cord-023439-r04y1j22	348	24	CD8	CD8	NNP
cord-023439-r04y1j22	348	25	þ	þ	NNP
cord-023439-r04y1j22	348	26	T	T	NNP
cord-023439-r04y1j22	348	27	cells	cell	NNS
cord-023439-r04y1j22	348	28	into	into	IN
cord-023439-r04y1j22	348	29	the	the	DT
cord-023439-r04y1j22	348	30	skin	skin	NN
cord-023439-r04y1j22	348	31	while	while	IN
cord-023439-r04y1j22	348	32	IL-12	IL-12	NNP
cord-023439-r04y1j22	348	33	promotes	promote	VBZ
cord-023439-r04y1j22	348	34	such	such	JJ
cord-023439-r04y1j22	348	35	migration	migration	NN
cord-023439-r04y1j22	348	36	.	.	.
cord-023439-r04y1j22	349	1	Thus	thus	RB
cord-023439-r04y1j22	349	2	,	,	,
cord-023439-r04y1j22	349	3	the	the	DT
cord-023439-r04y1j22	349	4	expression	expression	NN
cord-023439-r04y1j22	349	5	of	of	IN
cord-023439-r04y1j22	349	6	CLA	CLA	NNP
cord-023439-r04y1j22	349	7	and	and	CC
cord-023439-r04y1j22	349	8	CD103	CD103	NNP
cord-023439-r04y1j22	349	9	may	may	MD
cord-023439-r04y1j22	349	10	be	be	VB
cord-023439-r04y1j22	349	11	antagonistically	antagonistically	RB
cord-023439-r04y1j22	349	12	regulated	regulate	VBN
cord-023439-r04y1j22	349	13	by	by	IN
cord-023439-r04y1j22	349	14	IL-10	IL-10	NNP
cord-023439-r04y1j22	349	15	and	and	CC
cord-023439-r04y1j22	349	16	IL-12	IL-12	NNP
cord-023439-r04y1j22	349	17	,	,	,
cord-023439-r04y1j22	349	18	and	and	CC
cord-023439-r04y1j22	349	19	the	the	DT
cord-023439-r04y1j22	349	20	balance	balance	NN
cord-023439-r04y1j22	349	21	between	between	IN
cord-023439-r04y1j22	349	22	these	these	DT
cord-023439-r04y1j22	349	23	cytokines	cytokine	NNS
cord-023439-r04y1j22	349	24	could	could	MD
cord-023439-r04y1j22	349	25	influence	influence	VB
cord-023439-r04y1j22	349	26	the	the	DT
cord-023439-r04y1j22	349	27	T	t	NN
cord-023439-r04y1j22	349	28	-	-	HYPH
cord-023439-r04y1j22	349	29	cell	cell	NN
cord-023439-r04y1j22	349	30	migration	migration	NN
cord-023439-r04y1j22	349	31	of	of	IN
cord-023439-r04y1j22	349	32	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	349	33	cells	cell	NNS
cord-023439-r04y1j22	349	34	into	into	IN
cord-023439-r04y1j22	349	35	epithelial	epithelial	JJ
cord-023439-r04y1j22	349	36	tissues	tissue	NNS
cord-023439-r04y1j22	349	37	.	.	.
cord-023439-r04y1j22	350	1	During	during	IN
cord-023439-r04y1j22	350	2	contact	contact	NN
cord-023439-r04y1j22	350	3	sensitivity	sensitivity	NN
cord-023439-r04y1j22	350	4	reaction	reaction	NN
cord-023439-r04y1j22	350	5	,	,	,
cord-023439-r04y1j22	350	6	immune	immune	JJ
cord-023439-r04y1j22	350	7	cells	cell	NNS
cord-023439-r04y1j22	350	8	proliferate	proliferate	VBP
cord-023439-r04y1j22	350	9	.	.	.
cord-023439-r04y1j22	351	1	In	in	IN
cord-023439-r04y1j22	351	2	order	order	NN
cord-023439-r04y1j22	351	3	to	to	TO
cord-023439-r04y1j22	351	4	study	study	VB
cord-023439-r04y1j22	351	5	the	the	DT
cord-023439-r04y1j22	351	6	histological	histological	JJ
cord-023439-r04y1j22	351	7	picture	picture	NN
cord-023439-r04y1j22	351	8	of	of	IN
cord-023439-r04y1j22	351	9	these	these	DT
cord-023439-r04y1j22	351	10	proliferation	proliferation	NN
cord-023439-r04y1j22	351	11	phases	phase	NNS
cord-023439-r04y1j22	351	12	,	,	,
cord-023439-r04y1j22	351	13	we	-PRON-	PRP
cord-023439-r04y1j22	351	14	used	use	VBD
cord-023439-r04y1j22	351	15	a	a	DT
cord-023439-r04y1j22	351	16	mouse	mouse	NN
cord-023439-r04y1j22	351	17	model	model	NN
cord-023439-r04y1j22	351	18	of	of	IN
cord-023439-r04y1j22	351	19	contact	contact	NN
cord-023439-r04y1j22	351	20	sensitivity	sensitivity	NN
cord-023439-r04y1j22	351	21	in	in	IN
cord-023439-r04y1j22	351	22	the	the	DT
cord-023439-r04y1j22	351	23	oral	oral	JJ
cord-023439-r04y1j22	351	24	mucosa	mucosa	NN
cord-023439-r04y1j22	351	25	and	and	CC
cord-023439-r04y1j22	351	26	on	on	IN
cord-023439-r04y1j22	351	27	skin	skin	NN
cord-023439-r04y1j22	351	28	.	.	.
cord-023439-r04y1j22	352	1	We	-PRON-	PRP
cord-023439-r04y1j22	352	2	also	also	RB
cord-023439-r04y1j22	352	3	used	use	VBD
cord-023439-r04y1j22	352	4	bromodeoxyuridin	bromodeoxyuridin	NNP
cord-023439-r04y1j22	352	5	(	(	-LRB-
cord-023439-r04y1j22	352	6	BrdU	BrdU	NNP
cord-023439-r04y1j22	352	7	,	,	,
cord-023439-r04y1j22	352	8	an	an	DT
cord-023439-r04y1j22	352	9	analogue	analogue	NN
cord-023439-r04y1j22	352	10	to	to	TO
cord-023439-r04y1j22	352	11	thymidin	thymidin	VB
cord-023439-r04y1j22	352	12	)	)	-RRB-
cord-023439-r04y1j22	352	13	that	that	WDT
cord-023439-r04y1j22	352	14	is	be	VBZ
cord-023439-r04y1j22	352	15	incorporated	incorporate	VBN
cord-023439-r04y1j22	352	16	into	into	IN
cord-023439-r04y1j22	352	17	the	the	DT
cord-023439-r04y1j22	352	18	nucleus	nucleus	NN
cord-023439-r04y1j22	352	19	during	during	IN
cord-023439-r04y1j22	352	20	cell	cell	NN
cord-023439-r04y1j22	352	21	replication	replication	NN
cord-023439-r04y1j22	352	22	.	.	.
cord-023439-r04y1j22	353	1	The	the	DT
cord-023439-r04y1j22	353	2	hapten	hapten	NNP
cord-023439-r04y1j22	353	3	oxazolone	oxazolone	NN
cord-023439-r04y1j22	353	4	(	(	-LRB-
cord-023439-r04y1j22	353	5	OXA	OXA	NNP
cord-023439-r04y1j22	353	6	)	)	-RRB-
cord-023439-r04y1j22	353	7	was	be	VBD
cord-023439-r04y1j22	353	8	used	use	VBN
cord-023439-r04y1j22	353	9	to	to	TO
cord-023439-r04y1j22	353	10	sensitize	sensitize	VB
cord-023439-r04y1j22	353	11	and	and	CC
cord-023439-r04y1j22	353	12	elicit	elicit	VB
cord-023439-r04y1j22	353	13	the	the	DT
cord-023439-r04y1j22	353	14	oral	oral	JJ
cord-023439-r04y1j22	353	15	mucosa	mucosa	NN
cord-023439-r04y1j22	353	16	and/or	and/or	CC
cord-023439-r04y1j22	353	17	the	the	DT
cord-023439-r04y1j22	353	18	ear	ear	NN
cord-023439-r04y1j22	353	19	skin	skin	NN
cord-023439-r04y1j22	353	20	.	.	.
cord-023439-r04y1j22	354	1	Mice	mouse	NNS
cord-023439-r04y1j22	354	2	were	be	VBD
cord-023439-r04y1j22	354	3	killed	kill	VBN
cord-023439-r04y1j22	354	4	at	at	IN
cord-023439-r04y1j22	354	5	various	various	JJ
cord-023439-r04y1j22	354	6	times	time	NNS
cord-023439-r04y1j22	354	7	after	after	IN
cord-023439-r04y1j22	354	8	elicitation	elicitation	NN
cord-023439-r04y1j22	354	9	,	,	,
cord-023439-r04y1j22	354	10	and	and	CC
cord-023439-r04y1j22	354	11	unsensitized	unsensitized	JJ
cord-023439-r04y1j22	354	12	animals	animal	NNS
cord-023439-r04y1j22	354	13	were	be	VBD
cord-023439-r04y1j22	354	14	also	also	RB
cord-023439-r04y1j22	354	15	exposed	expose	VBN
cord-023439-r04y1j22	354	16	to	to	IN
cord-023439-r04y1j22	354	17	the	the	DT
cord-023439-r04y1j22	354	18	hapten	hapten	NNP
cord-023439-r04y1j22	354	19	as	as	IN
cord-023439-r04y1j22	354	20	controls	control	NNS
cord-023439-r04y1j22	354	21	.	.	.
cord-023439-r04y1j22	355	1	BrdU	BrdU	NNP
cord-023439-r04y1j22	355	2	(	(	-LRB-
cord-023439-r04y1j22	355	3	25	25	CD
cord-023439-r04y1j22	355	4	mg/	mg/	NN
cord-023439-r04y1j22	355	5	kg	kg	NNP
cord-023439-r04y1j22	355	6	animal	animal	NN
cord-023439-r04y1j22	355	7	)	)	-RRB-
cord-023439-r04y1j22	355	8	was	be	VBD
cord-023439-r04y1j22	355	9	injected	inject	VBN
cord-023439-r04y1j22	355	10	i.p	i.p	NNP
cord-023439-r04y1j22	355	11	.	.	NNP
cord-023439-r04y1j22	355	12	2	2	CD
cord-023439-r04y1j22	355	13	h	h	NN
cord-023439-r04y1j22	355	14	before	before	IN
cord-023439-r04y1j22	355	15	the	the	DT
cord-023439-r04y1j22	355	16	kill	kill	NN
cord-023439-r04y1j22	355	17	.	.	.
cord-023439-r04y1j22	356	1	Specimens	specimen	NNS
cord-023439-r04y1j22	356	2	from	from	IN
cord-023439-r04y1j22	356	3	the	the	DT
cord-023439-r04y1j22	356	4	oral	oral	JJ
cord-023439-r04y1j22	356	5	mucosa	mucosa	NN
cord-023439-r04y1j22	356	6	,	,	,
cord-023439-r04y1j22	356	7	ear	ear	NN
cord-023439-r04y1j22	356	8	skin	skin	NN
cord-023439-r04y1j22	356	9	and	and	CC
cord-023439-r04y1j22	356	10	submandibular	submandibular	JJ
cord-023439-r04y1j22	356	11	and	and	CC
cord-023439-r04y1j22	356	12	auricular	auricular	JJ
cord-023439-r04y1j22	356	13	lymph	lymph	NN
cord-023439-r04y1j22	356	14	nodes	node	NNS
cord-023439-r04y1j22	356	15	were	be	VBD
cord-023439-r04y1j22	356	16	cut	cut	VBN
cord-023439-r04y1j22	356	17	and	and	CC
cord-023439-r04y1j22	356	18	fixed	fix	VBN
cord-023439-r04y1j22	356	19	in	in	IN
cord-023439-r04y1j22	356	20	4	4	CD
cord-023439-r04y1j22	356	21	%	%	NN
cord-023439-r04y1j22	356	22	paraformaldehyde	paraformaldehyde	NNP
cord-023439-r04y1j22	356	23	.	.	.
cord-023439-r04y1j22	357	1	They	-PRON-	PRP
cord-023439-r04y1j22	357	2	were	be	VBD
cord-023439-r04y1j22	357	3	then	then	RB
cord-023439-r04y1j22	357	4	treated	treat	VBN
cord-023439-r04y1j22	357	5	with	with	IN
cord-023439-r04y1j22	357	6	acid	acid	NN
cord-023439-r04y1j22	357	7	and	and	CC
cord-023439-r04y1j22	357	8	biotinylated	biotinylated	JJ
cord-023439-r04y1j22	357	9	anti	anti	NNP
cord-023439-r04y1j22	357	10	-	-	NNP
cord-023439-r04y1j22	357	11	BrdU	BrdU	NNP
cord-023439-r04y1j22	357	12	antibody	antibody	NN
cord-023439-r04y1j22	357	13	and	and	CC
cord-023439-r04y1j22	357	14	developed	develop	VBD
cord-023439-r04y1j22	357	15	using	use	VBG
cord-023439-r04y1j22	357	16	ABC	ABC	NNP
cord-023439-r04y1j22	357	17	-	-	HYPH
cord-023439-r04y1j22	357	18	kit	kit	NN
cord-023439-r04y1j22	357	19	and	and	CC
cord-023439-r04y1j22	357	20	DAB	dab	NN
cord-023439-r04y1j22	357	21	.	.	.
cord-023439-r04y1j22	358	1	The	the	DT
cord-023439-r04y1j22	358	2	analyses	analysis	NNS
cord-023439-r04y1j22	358	3	were	be	VBD
cord-023439-r04y1j22	358	4	performed	perform	VBN
cord-023439-r04y1j22	358	5	using	use	VBG
cord-023439-r04y1j22	358	6	a	a	DT
cord-023439-r04y1j22	358	7	Leica	Leica	NNP
cord-023439-r04y1j22	358	8	light	light	JJ
cord-023439-r04y1j22	358	9	microscope	microscope	NN
cord-023439-r04y1j22	358	10	and	and	CC
cord-023439-r04y1j22	358	11	the	the	DT
cord-023439-r04y1j22	358	12	computer	computer	NN
cord-023439-r04y1j22	358	13	program	program	NN
cord-023439-r04y1j22	358	14	ANALYSIS	analysis	NN
cord-023439-r04y1j22	358	15	.	.	.
cord-023439-r04y1j22	359	1	In	in	IN
cord-023439-r04y1j22	359	2	the	the	DT
cord-023439-r04y1j22	359	3	oral	oral	JJ
cord-023439-r04y1j22	359	4	mucosa	mucosa	NN
cord-023439-r04y1j22	359	5	,	,	,
cord-023439-r04y1j22	359	6	the	the	DT
cord-023439-r04y1j22	359	7	frequency	frequency	NN
cord-023439-r04y1j22	359	8	of	of	IN
cord-023439-r04y1j22	359	9	proliferating	proliferate	VBG
cord-023439-r04y1j22	359	10	cells	cell	NNS
cord-023439-r04y1j22	359	11	were	be	VBD
cord-023439-r04y1j22	359	12	increasing	increase	VBG
cord-023439-r04y1j22	359	13	during	during	IN
cord-023439-r04y1j22	359	14	the	the	DT
cord-023439-r04y1j22	359	15	observation	observation	NN
cord-023439-r04y1j22	359	16	period	period	NN
cord-023439-r04y1j22	359	17	,	,	,
cord-023439-r04y1j22	359	18	4	4	CD
cord-023439-r04y1j22	359	19	-	-	SYM
cord-023439-r04y1j22	359	20	24	24	CD
cord-023439-r04y1j22	359	21	h	h	NN
cord-023439-r04y1j22	359	22	after	after	IN
cord-023439-r04y1j22	359	23	elicitation	elicitation	NN
cord-023439-r04y1j22	359	24	,	,	,
cord-023439-r04y1j22	359	25	regardless	regardless	RB
cord-023439-r04y1j22	359	26	of	of	IN
cord-023439-r04y1j22	359	27	site	site	NN
cord-023439-r04y1j22	359	28	of	of	IN
cord-023439-r04y1j22	359	29	sensitization	sensitization	NN
cord-023439-r04y1j22	359	30	.	.	.
cord-023439-r04y1j22	360	1	The	the	DT
cord-023439-r04y1j22	360	2	proliferating	proliferate	VBG
cord-023439-r04y1j22	360	3	cells	cell	NNS
cord-023439-r04y1j22	360	4	were	be	VBD
cord-023439-r04y1j22	360	5	found	find	VBN
cord-023439-r04y1j22	360	6	mainly	mainly	RB
cord-023439-r04y1j22	360	7	in	in	IN
cord-023439-r04y1j22	360	8	the	the	DT
cord-023439-r04y1j22	360	9	basal	basal	NN
cord-023439-r04y1j22	360	10	cell	cell	NN
cord-023439-r04y1j22	360	11	layer	layer	NN
cord-023439-r04y1j22	360	12	of	of	IN
cord-023439-r04y1j22	360	13	the	the	DT
cord-023439-r04y1j22	360	14	epithelium	epithelium	NN
cord-023439-r04y1j22	360	15	.	.	.
cord-023439-r04y1j22	361	1	Similar	similar	JJ
cord-023439-r04y1j22	361	2	patterns	pattern	NNS
cord-023439-r04y1j22	361	3	were	be	VBD
cord-023439-r04y1j22	361	4	found	find	VBN
cord-023439-r04y1j22	361	5	in	in	IN
cord-023439-r04y1j22	361	6	ear	ear	NN
cord-023439-r04y1j22	361	7	skin	skin	NN
cord-023439-r04y1j22	361	8	.	.	.
cord-023439-r04y1j22	362	1	The	the	DT
cord-023439-r04y1j22	362	2	regional	regional	JJ
cord-023439-r04y1j22	362	3	lymph	lymph	NN
cord-023439-r04y1j22	362	4	nodes	node	NNS
cord-023439-r04y1j22	362	5	demonstrated	demonstrate	VBD
cord-023439-r04y1j22	362	6	a	a	DT
cord-023439-r04y1j22	362	7	few	few	JJ
cord-023439-r04y1j22	362	8	scattered	scatter	VBN
cord-023439-r04y1j22	362	9	proliferating	proliferate	VBG
cord-023439-r04y1j22	362	10	cells	cell	NNS
cord-023439-r04y1j22	362	11	4	4	CD
cord-023439-r04y1j22	362	12	h	h	NN
cord-023439-r04y1j22	362	13	after	after	IN
cord-023439-r04y1j22	362	14	elicitation	elicitation	NN
cord-023439-r04y1j22	362	15	.	.	.
cord-023439-r04y1j22	363	1	After	after	IN
cord-023439-r04y1j22	363	2	24	24	CD
cord-023439-r04y1j22	363	3	h	h	NN
cord-023439-r04y1j22	363	4	,	,	,
cord-023439-r04y1j22	363	5	these	these	DT
cord-023439-r04y1j22	363	6	cells	cell	NNS
cord-023439-r04y1j22	363	7	were	be	VBD
cord-023439-r04y1j22	363	8	found	find	VBN
cord-023439-r04y1j22	363	9	frequently	frequently	RB
cord-023439-r04y1j22	363	10	in	in	IN
cord-023439-r04y1j22	363	11	the	the	DT
cord-023439-r04y1j22	363	12	whole	whole	JJ
cord-023439-r04y1j22	363	13	lymph	lymph	NN
cord-023439-r04y1j22	363	14	node	node	NN
cord-023439-r04y1j22	363	15	.	.	.
cord-023439-r04y1j22	364	1	Control	control	NN
cord-023439-r04y1j22	364	2	animals	animal	NNS
cord-023439-r04y1j22	364	3	exhibited	exhibit	VBD
cord-023439-r04y1j22	364	4	considerable	considerable	JJ
cord-023439-r04y1j22	364	5	less	less	RBR
cord-023439-r04y1j22	364	6	proliferating	proliferate	VBG
cord-023439-r04y1j22	364	7	cells	cell	NNS
cord-023439-r04y1j22	364	8	at	at	IN
cord-023439-r04y1j22	364	9	all	all	DT
cord-023439-r04y1j22	364	10	times	time	NNS
cord-023439-r04y1j22	364	11	.	.	.
cord-023439-r04y1j22	365	1	We	-PRON-	PRP
cord-023439-r04y1j22	365	2	conclude	conclude	VBP
cord-023439-r04y1j22	365	3	that	that	IN
cord-023439-r04y1j22	365	4	most	most	RBS
cord-023439-r04y1j22	365	5	proliferating	proliferate	VBG
cord-023439-r04y1j22	365	6	cells	cell	NNS
cord-023439-r04y1j22	365	7	were	be	VBD
cord-023439-r04y1j22	365	8	found	find	VBN
cord-023439-r04y1j22	365	9	24	24	CD
cord-023439-r04y1j22	365	10	h	h	NN
cord-023439-r04y1j22	365	11	after	after	IN
cord-023439-r04y1j22	365	12	elicitation	elicitation	NN
cord-023439-r04y1j22	365	13	locally	locally	RB
cord-023439-r04y1j22	365	14	at	at	IN
cord-023439-r04y1j22	365	15	the	the	DT
cord-023439-r04y1j22	365	16	hapten	hapten	NN
cord-023439-r04y1j22	365	17	-	-	HYPH
cord-023439-r04y1j22	365	18	exposed	expose	VBN
cord-023439-r04y1j22	365	19	sites	site	NNS
cord-023439-r04y1j22	365	20	(	(	-LRB-
cord-023439-r04y1j22	365	21	the	the	DT
cord-023439-r04y1j22	365	22	oral	oral	JJ
cord-023439-r04y1j22	365	23	mucosa	mucosa	NN
cord-023439-r04y1j22	365	24	or	or	CC
cord-023439-r04y1j22	365	25	the	the	DT
cord-023439-r04y1j22	365	26	ear	ear	NN
cord-023439-r04y1j22	365	27	skin	skin	NN
cord-023439-r04y1j22	365	28	)	)	-RRB-
cord-023439-r04y1j22	365	29	as	as	RB
cord-023439-r04y1j22	365	30	well	well	RB
cord-023439-r04y1j22	365	31	as	as	IN
cord-023439-r04y1j22	365	32	in	in	IN
cord-023439-r04y1j22	365	33	the	the	DT
cord-023439-r04y1j22	365	34	regional	regional	JJ
cord-023439-r04y1j22	365	35	lymph	lymph	NN
cord-023439-r04y1j22	365	36	nodes	node	NNS
cord-023439-r04y1j22	365	37	.	.	.
cord-023439-r04y1j22	366	1	The	the	DT
cord-023439-r04y1j22	366	2	endogenous	endogenous	JJ
cord-023439-r04y1j22	366	3	nucleoside	nucleoside	NN
cord-023439-r04y1j22	366	4	adenosine	adenosine	NN
cord-023439-r04y1j22	366	5	is	be	VBZ
cord-023439-r04y1j22	366	6	released	release	VBN
cord-023439-r04y1j22	366	7	in	in	IN
cord-023439-r04y1j22	366	8	excess	excess	NN
cord-023439-r04y1j22	366	9	during	during	IN
cord-023439-r04y1j22	366	10	inflammation	inflammation	NN
cord-023439-r04y1j22	366	11	or	or	CC
cord-023439-r04y1j22	366	12	other	other	JJ
cord-023439-r04y1j22	366	13	metabolic	metabolic	JJ
cord-023439-r04y1j22	366	14	stress	stress	NN
cord-023439-r04y1j22	366	15	and	and	CC
cord-023439-r04y1j22	366	16	is	be	VBZ
cord-023439-r04y1j22	366	17	generally	generally	RB
cord-023439-r04y1j22	366	18	known	know	VBN
cord-023439-r04y1j22	366	19	to	to	TO
cord-023439-r04y1j22	366	20	deliver	deliver	VB
cord-023439-r04y1j22	366	21	tissue	tissue	NN
cord-023439-r04y1j22	366	22	protective	protective	JJ
cord-023439-r04y1j22	366	23	anti	anti	JJ
cord-023439-r04y1j22	366	24	-	-	JJ
cord-023439-r04y1j22	366	25	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	366	26	effects	effect	NNS
cord-023439-r04y1j22	366	27	.	.	.
cord-023439-r04y1j22	367	1	Adenosine	adenosine	NN
cord-023439-r04y1j22	367	2	acts	act	VBZ
cord-023439-r04y1j22	367	3	via	via	IN
cord-023439-r04y1j22	367	4	four	four	CD
cord-023439-r04y1j22	367	5	adenosine	adenosine	NN
cord-023439-r04y1j22	367	6	receptors	receptor	NNS
cord-023439-r04y1j22	367	7	of	of	IN
cord-023439-r04y1j22	367	8	which	which	WDT
cord-023439-r04y1j22	367	9	the	the	DT
cord-023439-r04y1j22	367	10	A2a	A2a	NNP
cord-023439-r04y1j22	367	11	receptor	receptor	NN
cord-023439-r04y1j22	367	12	is	be	VBZ
cord-023439-r04y1j22	367	13	the	the	DT
cord-023439-r04y1j22	367	14	predominant	predominant	JJ
cord-023439-r04y1j22	367	15	form	form	NN
cord-023439-r04y1j22	367	16	in	in	IN
cord-023439-r04y1j22	367	17	T	t	NN
cord-023439-r04y1j22	367	18	cells	cell	NNS
cord-023439-r04y1j22	367	19	.	.	.
cord-023439-r04y1j22	368	1	Adenosine	adenosine	NN
cord-023439-r04y1j22	368	2	levels	level	NNS
cord-023439-r04y1j22	368	3	are	be	VBP
cord-023439-r04y1j22	368	4	elevated	elevate	VBN
cord-023439-r04y1j22	368	5	in	in	IN
cord-023439-r04y1j22	368	6	asthmatic	asthmatic	JJ
cord-023439-r04y1j22	368	7	lung	lung	NN
cord-023439-r04y1j22	368	8	,	,	,
cord-023439-r04y1j22	368	9	and	and	CC
cord-023439-r04y1j22	368	10	adenosine	adenosine	NN
cord-023439-r04y1j22	368	11	can	can	MD
cord-023439-r04y1j22	368	12	directly	directly	RB
cord-023439-r04y1j22	368	13	induce	induce	VB
cord-023439-r04y1j22	368	14	mast	mast	JJ
cord-023439-r04y1j22	368	15	cell	cell	NN
cord-023439-r04y1j22	368	16	degranulation	degranulation	NN
cord-023439-r04y1j22	368	17	and	and	CC
cord-023439-r04y1j22	368	18	bronchoconstriction	bronchoconstriction	NN
cord-023439-r04y1j22	368	19	in	in	IN
cord-023439-r04y1j22	368	20	these	these	DT
cord-023439-r04y1j22	368	21	patients	patient	NNS
cord-023439-r04y1j22	368	22	.	.	.
cord-023439-r04y1j22	369	1	Instead	instead	RB
cord-023439-r04y1j22	369	2	,	,	,
cord-023439-r04y1j22	369	3	the	the	DT
cord-023439-r04y1j22	369	4	role	role	NN
cord-023439-r04y1j22	369	5	of	of	IN
cord-023439-r04y1j22	369	6	anti	anti	JJ
cord-023439-r04y1j22	369	7	-	-	JJ
cord-023439-r04y1j22	369	8	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	369	9	mechanisms	mechanism	NNS
cord-023439-r04y1j22	369	10	of	of	IN
cord-023439-r04y1j22	369	11	adenosine	adenosine	NN
cord-023439-r04y1j22	369	12	on	on	IN
cord-023439-r04y1j22	369	13	T	T	NNP
cord-023439-r04y1j22	369	14	cells	cell	NNS
cord-023439-r04y1j22	369	15	in	in	IN
cord-023439-r04y1j22	369	16	asthma	asthma	NN
cord-023439-r04y1j22	369	17	is	be	VBZ
cord-023439-r04y1j22	369	18	unclear	unclear	JJ
cord-023439-r04y1j22	369	19	.	.	.
cord-023439-r04y1j22	370	1	Aim	aim	VB
cord-023439-r04y1j22	370	2	:	:	:
cord-023439-r04y1j22	370	3	To	to	TO
cord-023439-r04y1j22	370	4	study	study	VB
cord-023439-r04y1j22	370	5	the	the	DT
cord-023439-r04y1j22	370	6	A2a	A2a	NNP
cord-023439-r04y1j22	370	7	receptor	receptor	NN
cord-023439-r04y1j22	370	8	expression	expression	NN
cord-023439-r04y1j22	370	9	in	in	IN
cord-023439-r04y1j22	370	10	peripheral	peripheral	JJ
cord-023439-r04y1j22	370	11	blood	blood	NN
cord-023439-r04y1j22	370	12	CD4	CD4	NNP
cord-023439-r04y1j22	370	13	þ	þ	NNP
cord-023439-r04y1j22	370	14	T	t	NN
cord-023439-r04y1j22	370	15	cells	cell	NNS
cord-023439-r04y1j22	370	16	in	in	IN
cord-023439-r04y1j22	370	17	asthmatic	asthmatic	JJ
cord-023439-r04y1j22	370	18	and	and	CC
cord-023439-r04y1j22	370	19	healthy	healthy	JJ
cord-023439-r04y1j22	370	20	individuals	individual	NNS
cord-023439-r04y1j22	370	21	using	use	VBG
cord-023439-r04y1j22	370	22	flow	flow	NN
cord-023439-r04y1j22	370	23	cytometric	cytometric	JJ
cord-023439-r04y1j22	370	24	and	and	CC
cord-023439-r04y1j22	370	25	quantitative	quantitative	JJ
cord-023439-r04y1j22	370	26	real	real	JJ
cord-023439-r04y1j22	370	27	-	-	HYPH
cord-023439-r04y1j22	370	28	time	time	NN
cord-023439-r04y1j22	370	29	PCR	pcr	NN
cord-023439-r04y1j22	370	30	methods	method	NNS
cord-023439-r04y1j22	370	31	.	.	.
cord-023439-r04y1j22	371	1	Results	result	NNS
cord-023439-r04y1j22	371	2	:	:	:
cord-023439-r04y1j22	372	1	Unstimulated	unstimulated	JJ
cord-023439-r04y1j22	372	2	CD4	CD4	NNP
cord-023439-r04y1j22	372	3	þ	þ	NNP
cord-023439-r04y1j22	372	4	cells	cell	NNS
cord-023439-r04y1j22	372	5	of	of	IN
cord-023439-r04y1j22	372	6	asthmatic	asthmatic	JJ
cord-023439-r04y1j22	372	7	patients	patient	NNS
cord-023439-r04y1j22	372	8	expressed	express	VBD
cord-023439-r04y1j22	372	9	significantly	significantly	RB
cord-023439-r04y1j22	372	10	lower	low	JJR
cord-023439-r04y1j22	372	11	levels	level	NNS
cord-023439-r04y1j22	372	12	(	(	-LRB-
cord-023439-r04y1j22	372	13	P	p	NN
cord-023439-r04y1j22	372	14	<	<	XX
cord-023439-r04y1j22	372	15	0.001	0.001	CD
cord-023439-r04y1j22	372	16	)	)	-RRB-
cord-023439-r04y1j22	372	17	of	of	IN
cord-023439-r04y1j22	372	18	A2a	a2a	CD
cord-023439-r04y1j22	372	19	receptor	receptor	NN
cord-023439-r04y1j22	372	20	in	in	IN
cord-023439-r04y1j22	372	21	protein	protein	NN
cord-023439-r04y1j22	372	22	level	level	NN
cord-023439-r04y1j22	372	23	(	(	-LRB-
cord-023439-r04y1j22	372	24	mean	mean	JJ
cord-023439-r04y1j22	372	25	percentage	percentage	NN
cord-023439-r04y1j22	372	26	of	of	IN
cord-023439-r04y1j22	372	27	cells	cell	NNS
cord-023439-r04y1j22	372	28	positive	positive	JJ
cord-023439-r04y1j22	372	29	AE	AE	NNP
cord-023439-r04y1j22	372	30	SEM	SEM	NNP
cord-023439-r04y1j22	372	31	:	:	:
cord-023439-r04y1j22	372	32	76.8	76.8	CD
cord-023439-r04y1j22	372	33	AE	AE	NNP
cord-023439-r04y1j22	372	34	1.2	1.2	CD
cord-023439-r04y1j22	372	35	,	,	,
cord-023439-r04y1j22	372	36	n	n	NN
cord-023439-r04y1j22	372	37	¼	¼	NNP
cord-023439-r04y1j22	372	38	6	6	CD
cord-023439-r04y1j22	372	39	)	)	-RRB-
cord-023439-r04y1j22	372	40	compared	compare	VBN
cord-023439-r04y1j22	372	41	to	to	IN
cord-023439-r04y1j22	372	42	healthy	healthy	JJ
cord-023439-r04y1j22	372	43	individuals	individual	NNS
cord-023439-r04y1j22	372	44	(	(	-LRB-
cord-023439-r04y1j22	372	45	90.4	90.4	CD
cord-023439-r04y1j22	372	46	%	%	NN
cord-023439-r04y1j22	372	47	AE	AE	NNP
cord-023439-r04y1j22	372	48	1.9	1.9	CD
cord-023439-r04y1j22	372	49	,	,	,
cord-023439-r04y1j22	372	50	n	n	NN
cord-023439-r04y1j22	372	51	¼	¼	NNP
cord-023439-r04y1j22	372	52	4	4	CD
cord-023439-r04y1j22	372	53	)	)	-RRB-
cord-023439-r04y1j22	372	54	.	.	.
cord-023439-r04y1j22	373	1	Double	double	JJ
cord-023439-r04y1j22	373	2	staining	staining	NN
cord-023439-r04y1j22	373	3	for	for	IN
cord-023439-r04y1j22	373	4	CD69	CD69	NNP
cord-023439-r04y1j22	373	5	expression	expression	NN
cord-023439-r04y1j22	373	6	showed	show	VBD
cord-023439-r04y1j22	373	7	that	that	IN
cord-023439-r04y1j22	373	8	stimulation	stimulation	NN
cord-023439-r04y1j22	373	9	of	of	IN
cord-023439-r04y1j22	373	10	CD4	CD4	NNP
cord-023439-r04y1j22	373	11	þ	þ	NNP
cord-023439-r04y1j22	373	12	cells	cell	NNS
cord-023439-r04y1j22	373	13	decreased	decrease	VBD
cord-023439-r04y1j22	373	14	A2a	a2a	DT
cord-023439-r04y1j22	373	15	expression	expression	NN
cord-023439-r04y1j22	373	16	in	in	IN
cord-023439-r04y1j22	373	17	both	both	DT
cord-023439-r04y1j22	373	18	groups	group	NNS
cord-023439-r04y1j22	373	19	but	but	CC
cord-023439-r04y1j22	373	20	indicated	indicate	VBD
cord-023439-r04y1j22	373	21	that	that	IN
cord-023439-r04y1j22	373	22	the	the	DT
cord-023439-r04y1j22	373	23	detected	detect	VBN
cord-023439-r04y1j22	373	24	lower	low	JJR
cord-023439-r04y1j22	373	25	levels	level	NNS
cord-023439-r04y1j22	373	26	of	of	IN
cord-023439-r04y1j22	373	27	A2a	a2a	CD
cord-023439-r04y1j22	373	28	in	in	IN
cord-023439-r04y1j22	373	29	unstimulated	unstimulated	JJ
cord-023439-r04y1j22	373	30	cells	cell	NNS
cord-023439-r04y1j22	373	31	of	of	IN
cord-023439-r04y1j22	373	32	asthmatics	asthmatic	NNS
cord-023439-r04y1j22	373	33	was	be	VBD
cord-023439-r04y1j22	373	34	not	not	RB
cord-023439-r04y1j22	373	35	due	due	JJ
cord-023439-r04y1j22	373	36	to	to	IN
cord-023439-r04y1j22	373	37	preactivation	preactivation	NN
cord-023439-r04y1j22	373	38	in	in	IN
cord-023439-r04y1j22	373	39	these	these	DT
cord-023439-r04y1j22	373	40	patients	patient	NNS
cord-023439-r04y1j22	373	41	.	.	.
cord-023439-r04y1j22	374	1	Surprisingly	surprisingly	RB
cord-023439-r04y1j22	374	2	,	,	,
cord-023439-r04y1j22	374	3	A2a	a2a	DT
cord-023439-r04y1j22	374	4	mRNA	mrna	NN
cord-023439-r04y1j22	374	5	expression	expression	NN
cord-023439-r04y1j22	374	6	in	in	IN
cord-023439-r04y1j22	374	7	unstimulated	unstimulated	JJ
cord-023439-r04y1j22	374	8	CD4	CD4	NNP
cord-023439-r04y1j22	374	9	þ	þ	NNP
cord-023439-r04y1j22	374	10	cells	cell	NNS
cord-023439-r04y1j22	374	11	was	be	VBD
cord-023439-r04y1j22	374	12	significantly	significantly	RB
cord-023439-r04y1j22	374	13	higher	high	JJR
cord-023439-r04y1j22	374	14	(	(	-LRB-
cord-023439-r04y1j22	374	15	P	p	NN
cord-023439-r04y1j22	374	16	<	<	XX
cord-023439-r04y1j22	374	17	0.05	0.05	CD
cord-023439-r04y1j22	374	18	)	)	-RRB-
cord-023439-r04y1j22	374	19	in	in	IN
cord-023439-r04y1j22	374	20	asthmatics	asthmatic	NNS
cord-023439-r04y1j22	374	21	(	(	-LRB-
cord-023439-r04y1j22	374	22	n	n	CC
cord-023439-r04y1j22	374	23	¼	¼	NNP
cord-023439-r04y1j22	374	24	28	28	CD
cord-023439-r04y1j22	374	25	)	)	-RRB-
cord-023439-r04y1j22	374	26	compared	compare	VBN
cord-023439-r04y1j22	374	27	to	to	IN
cord-023439-r04y1j22	374	28	healthy	healthy	JJ
cord-023439-r04y1j22	374	29	controls	control	NNS
cord-023439-r04y1j22	374	30	(	(	-LRB-
cord-023439-r04y1j22	374	31	n	n	CC
cord-023439-r04y1j22	374	32	¼	¼	NNP
cord-023439-r04y1j22	374	33	7	7	CD
cord-023439-r04y1j22	374	34	)	)	-RRB-
cord-023439-r04y1j22	374	35	.	.	.
cord-023439-r04y1j22	375	1	The	the	DT
cord-023439-r04y1j22	375	2	expression	expression	NN
cord-023439-r04y1j22	375	3	did	do	VBD
cord-023439-r04y1j22	375	4	not	not	RB
cord-023439-r04y1j22	375	5	correlate	correlate	VB
cord-023439-r04y1j22	375	6	with	with	IN
cord-023439-r04y1j22	375	7	serum	serum	NNP
cord-023439-r04y1j22	375	8	total	total	JJ
cord-023439-r04y1j22	375	9	IgE	IgE	NNP
cord-023439-r04y1j22	375	10	levels	level	NNS
cord-023439-r04y1j22	375	11	.	.	.
cord-023439-r04y1j22	376	1	Conclusions	conclusion	NNS
cord-023439-r04y1j22	376	2	:	:	:
cord-023439-r04y1j22	377	1	Asthmatic	asthmatic	JJ
cord-023439-r04y1j22	377	2	individuals	individual	NNS
cord-023439-r04y1j22	377	3	express	express	VBP
cord-023439-r04y1j22	377	4	less	less	RBR
cord-023439-r04y1j22	377	5	A2a	a2a	CD
cord-023439-r04y1j22	377	6	adenosine	adenosine	NN
cord-023439-r04y1j22	377	7	receptor	receptor	NN
cord-023439-r04y1j22	377	8	on	on	IN
cord-023439-r04y1j22	377	9	their	-PRON-	PRP$
cord-023439-r04y1j22	377	10	peripheral	peripheral	JJ
cord-023439-r04y1j22	377	11	CD4	CD4	NNP
cord-023439-r04y1j22	377	12	þ	þ	NNP
cord-023439-r04y1j22	377	13	T	t	NN
cord-023439-r04y1j22	377	14	cells	cell	NNS
cord-023439-r04y1j22	377	15	.	.	.
cord-023439-r04y1j22	378	1	The	the	DT
cord-023439-r04y1j22	378	2	higher	high	JJR
cord-023439-r04y1j22	378	3	mRNA	mrna	NN
cord-023439-r04y1j22	378	4	levels	level	NNS
cord-023439-r04y1j22	378	5	instead	instead	RB
cord-023439-r04y1j22	378	6	may	may	MD
cord-023439-r04y1j22	378	7	point	point	VB
cord-023439-r04y1j22	378	8	to	to	IN
cord-023439-r04y1j22	378	9	a	a	DT
cord-023439-r04y1j22	378	10	negative	negative	JJ
cord-023439-r04y1j22	378	11	feedback	feedback	NN
cord-023439-r04y1j22	378	12	regulation	regulation	NN
cord-023439-r04y1j22	378	13	in	in	IN
cord-023439-r04y1j22	378	14	the	the	DT
cord-023439-r04y1j22	378	15	receptor	receptor	NN
cord-023439-r04y1j22	378	16	expression	expression	NN
cord-023439-r04y1j22	378	17	.	.	.
cord-023439-r04y1j22	379	1	The	the	DT
cord-023439-r04y1j22	379	2	role	role	NN
cord-023439-r04y1j22	379	3	of	of	IN
cord-023439-r04y1j22	379	4	possibly	possibly	RB
cord-023439-r04y1j22	379	5	decreased	decrease	VBD
cord-023439-r04y1j22	379	6	adenosine	adenosine	NN
cord-023439-r04y1j22	379	7	-	-	HYPH
cord-023439-r04y1j22	379	8	mediated	mediate	VBN
cord-023439-r04y1j22	379	9	anti	anti	JJ
cord-023439-r04y1j22	379	10	-	-	JJ
cord-023439-r04y1j22	379	11	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	379	12	effects	effect	NNS
cord-023439-r04y1j22	379	13	in	in	IN
cord-023439-r04y1j22	379	14	asthma	asthma	NN
cord-023439-r04y1j22	379	15	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	379	16	require	require	VBP
cord-023439-r04y1j22	379	17	further	further	JJ
cord-023439-r04y1j22	379	18	studies	study	NNS
cord-023439-r04y1j22	379	19	on	on	IN
cord-023439-r04y1j22	379	20	this	this	DT
cord-023439-r04y1j22	379	21	T	t	NN
cord-023439-r04y1j22	379	22	-	-	HYPH
cord-023439-r04y1j22	379	23	cell	cell	NN
cord-023439-r04y1j22	379	24	mediated	mediate	VBN
cord-023439-r04y1j22	379	25	disease	disease	NN
cord-023439-r04y1j22	379	26	.	.	.
cord-023439-r04y1j22	380	1	The	the	DT
cord-023439-r04y1j22	380	2	chronic	chronic	JJ
cord-023439-r04y1j22	380	3	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	380	4	skin	skin	NN
cord-023439-r04y1j22	380	5	disease	disease	NN
cord-023439-r04y1j22	380	6	atopic	atopic	NN
cord-023439-r04y1j22	380	7	eczema	eczema	NN
cord-023439-r04y1j22	380	8	(	(	-LRB-
cord-023439-r04y1j22	380	9	AE	AE	NNP
cord-023439-r04y1j22	380	10	)	)	-RRB-
cord-023439-r04y1j22	380	11	affects	affect	VBZ
cord-023439-r04y1j22	380	12	almost	almost	RB
cord-023439-r04y1j22	380	13	15	15	CD
cord-023439-r04y1j22	380	14	%	%	NN
cord-023439-r04y1j22	380	15	of	of	IN
cord-023439-r04y1j22	380	16	the	the	DT
cord-023439-r04y1j22	380	17	population	population	NN
cord-023439-r04y1j22	380	18	in	in	IN
cord-023439-r04y1j22	380	19	many	many	JJ
cord-023439-r04y1j22	380	20	countries	country	NNS
cord-023439-r04y1j22	380	21	today	today	NN
cord-023439-r04y1j22	380	22	.	.	.
cord-023439-r04y1j22	381	1	The	the	DT
cord-023439-r04y1j22	381	2	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	381	3	of	of	IN
cord-023439-r04y1j22	381	4	AE	AE	NNP
cord-023439-r04y1j22	381	5	is	be	VBZ
cord-023439-r04y1j22	381	6	not	not	RB
cord-023439-r04y1j22	381	7	fully	fully	RB
cord-023439-r04y1j22	381	8	understood	understand	VBN
cord-023439-r04y1j22	381	9	.	.	.
cord-023439-r04y1j22	382	1	A	a	DT
cord-023439-r04y1j22	382	2	combination	combination	NN
cord-023439-r04y1j22	382	3	of	of	IN
cord-023439-r04y1j22	382	4	genetic	genetic	JJ
cord-023439-r04y1j22	382	5	predisposition	predisposition	NN
cord-023439-r04y1j22	382	6	and	and	CC
cord-023439-r04y1j22	382	7	environmental	environmental	JJ
cord-023439-r04y1j22	382	8	factors	factor	NNS
cord-023439-r04y1j22	382	9	like	like	IN
cord-023439-r04y1j22	382	10	microorganisms	microorganism	NNS
cord-023439-r04y1j22	382	11	seems	seem	VBZ
cord-023439-r04y1j22	382	12	to	to	TO
cord-023439-r04y1j22	382	13	contribute	contribute	VB
cord-023439-r04y1j22	382	14	to	to	IN
cord-023439-r04y1j22	382	15	the	the	DT
cord-023439-r04y1j22	382	16	symptoms	symptom	NNS
cord-023439-r04y1j22	382	17	.	.	.
cord-023439-r04y1j22	383	1	The	the	DT
cord-023439-r04y1j22	383	2	yeast	yeast	NN
cord-023439-r04y1j22	383	3	Malassezia	Malassezia	NNP
cord-023439-r04y1j22	383	4	sympodialis	sympodialis	NNP
cord-023439-r04y1j22	383	5	is	be	VBZ
cord-023439-r04y1j22	383	6	part	part	NN
cord-023439-r04y1j22	383	7	of	of	IN
cord-023439-r04y1j22	383	8	our	-PRON-	PRP$
cord-023439-r04y1j22	383	9	normal	normal	JJ
cord-023439-r04y1j22	383	10	skin	skin	NN
cord-023439-r04y1j22	383	11	micro	micro	NN
cord-023439-r04y1j22	383	12	flora	flora	NN
cord-023439-r04y1j22	383	13	but	but	CC
cord-023439-r04y1j22	383	14	can	can	MD
cord-023439-r04y1j22	383	15	act	act	VB
cord-023439-r04y1j22	383	16	as	as	IN
cord-023439-r04y1j22	383	17	an	an	DT
cord-023439-r04y1j22	383	18	allergen	allergen	NN
cord-023439-r04y1j22	383	19	and	and	CC
cord-023439-r04y1j22	383	20	elicit	elicit	VB
cord-023439-r04y1j22	383	21	specific	specific	JJ
cord-023439-r04y1j22	383	22	IgE	IgE	NNP
cord-023439-r04y1j22	383	23	and	and	CC
cord-023439-r04y1j22	383	24	T	t	NN
cord-023439-r04y1j22	383	25	-	-	HYPH
cord-023439-r04y1j22	383	26	cell	cell	NN
cord-023439-r04y1j22	383	27	reactivity	reactivity	NN
cord-023439-r04y1j22	383	28	in	in	IN
cord-023439-r04y1j22	383	29	patients	patient	NNS
cord-023439-r04y1j22	383	30	with	with	IN
cord-023439-r04y1j22	383	31	AE	AE	NNP
cord-023439-r04y1j22	383	32	.	.	.
cord-023439-r04y1j22	384	1	Recently	recently	RB
cord-023439-r04y1j22	384	2	,	,	,
cord-023439-r04y1j22	384	3	we	-PRON-	PRP
cord-023439-r04y1j22	384	4	identified	identify	VBD
cord-023439-r04y1j22	384	5	a	a	DT
cord-023439-r04y1j22	384	6	novel	novel	JJ
cord-023439-r04y1j22	384	7	major	major	JJ
cord-023439-r04y1j22	384	8	M.	M.	NNP
cord-023439-r04y1j22	384	9	sympodialis	sympodialis	JJ
cord-023439-r04y1j22	384	10	allergen	allergen	NN
cord-023439-r04y1j22	384	11	,	,	,
cord-023439-r04y1j22	384	12	designated	designate	VBN
cord-023439-r04y1j22	384	13	Mala	Mala	NNP
cord-023439-r04y1j22	384	14	s	s	POS
cord-023439-r04y1j22	384	15	11	11	CD
cord-023439-r04y1j22	384	16	(	(	-LRB-
cord-023439-r04y1j22	384	17	22.4	22.4	CD
cord-023439-r04y1j22	384	18	kDa	kDa	NNPS
cord-023439-r04y1j22	384	19	)	)	-RRB-
cord-023439-r04y1j22	384	20	,	,	,
cord-023439-r04y1j22	384	21	with	with	IN
cord-023439-r04y1j22	384	22	sequence	sequence	NN
cord-023439-r04y1j22	384	23	similarity	similarity	NN
cord-023439-r04y1j22	384	24	to	to	IN
cord-023439-r04y1j22	384	25	the	the	DT
cord-023439-r04y1j22	384	26	mitochondrial	mitochondrial	JJ
cord-023439-r04y1j22	384	27	enzyme	enzyme	NN
cord-023439-r04y1j22	384	28	manganese	manganese	NN
cord-023439-r04y1j22	384	29	superoxide	superoxide	NN
cord-023439-r04y1j22	384	30	dismutase	dismutase	NN
cord-023439-r04y1j22	384	31	(	(	-LRB-
cord-023439-r04y1j22	384	32	MnSOD	MnSOD	NNP
cord-023439-r04y1j22	384	33	)	)	-RRB-
cord-023439-r04y1j22	384	34	.	.	.
cord-023439-r04y1j22	385	1	Interestingly	interestingly	RB
cord-023439-r04y1j22	385	2	,	,	,
cord-023439-r04y1j22	385	3	Mala	Mala	NNP
cord-023439-r04y1j22	385	4	s	s	POS
cord-023439-r04y1j22	385	5	11	11	CD
cord-023439-r04y1j22	385	6	has	have	VBZ
cord-023439-r04y1j22	385	7	a	a	DT
cord-023439-r04y1j22	385	8	high	high	JJ
cord-023439-r04y1j22	385	9	degree	degree	NN
cord-023439-r04y1j22	385	10	of	of	IN
cord-023439-r04y1j22	385	11	homology	homology	NN
cord-023439-r04y1j22	385	12	to	to	IN
cord-023439-r04y1j22	385	13	human	human	JJ
cord-023439-r04y1j22	385	14	MnSOD	MnSOD	NNP
cord-023439-r04y1j22	385	15	.	.	.
cord-023439-r04y1j22	386	1	The	the	DT
cord-023439-r04y1j22	386	2	aim	aim	NN
cord-023439-r04y1j22	386	3	of	of	IN
cord-023439-r04y1j22	386	4	this	this	DT
cord-023439-r04y1j22	386	5	study	study	NN
cord-023439-r04y1j22	386	6	was	be	VBD
cord-023439-r04y1j22	386	7	to	to	TO
cord-023439-r04y1j22	386	8	examine	examine	VB
cord-023439-r04y1j22	386	9	the	the	DT
cord-023439-r04y1j22	386	10	effects	effect	NNS
cord-023439-r04y1j22	386	11	of	of	IN
cord-023439-r04y1j22	386	12	recombinant	recombinant	JJ
cord-023439-r04y1j22	386	13	Mala	Mala	NNP
cord-023439-r04y1j22	386	14	s	s	POS
cord-023439-r04y1j22	386	15	11	11	CD
cord-023439-r04y1j22	386	16	on	on	IN
cord-023439-r04y1j22	386	17	antigen	antigen	NN
cord-023439-r04y1j22	386	18	-	-	HYPH
cord-023439-r04y1j22	386	19	presenting	present	VBG
cord-023439-r04y1j22	386	20	dendritic	dendritic	JJ
cord-023439-r04y1j22	386	21	cells	cell	NNS
cord-023439-r04y1j22	386	22	.	.	.
cord-023439-r04y1j22	387	1	Monocytederived	monocytederived	JJ
cord-023439-r04y1j22	387	2	dendritic	dendritic	JJ
cord-023439-r04y1j22	387	3	cells	cell	NNS
cord-023439-r04y1j22	387	4	(	(	-LRB-
cord-023439-r04y1j22	387	5	MDDCs	mddc	NNS
cord-023439-r04y1j22	387	6	)	)	-RRB-
cord-023439-r04y1j22	387	7	from	from	IN
cord-023439-r04y1j22	387	8	healthy	healthy	JJ
cord-023439-r04y1j22	387	9	blood	blood	NN
cord-023439-r04y1j22	387	10	donors	donor	NNS
cord-023439-r04y1j22	387	11	were	be	VBD
cord-023439-r04y1j22	387	12	cultured	culture	VBN
cord-023439-r04y1j22	387	13	with	with	IN
cord-023439-r04y1j22	387	14	or	or	CC
cord-023439-r04y1j22	387	15	without	without	IN
cord-023439-r04y1j22	387	16	Mala	Mala	NNP
cord-023439-r04y1j22	387	17	s	s	NNP
cord-023439-r04y1j22	387	18	11	11	CD
cord-023439-r04y1j22	387	19	for	for	IN
cord-023439-r04y1j22	387	20	different	different	JJ
cord-023439-r04y1j22	387	21	time	time	NN
cord-023439-r04y1j22	387	22	periods	period	NNS
cord-023439-r04y1j22	387	23	.	.	.
cord-023439-r04y1j22	388	1	It	-PRON-	PRP
cord-023439-r04y1j22	388	2	was	be	VBD
cord-023439-r04y1j22	388	3	found	find	VBN
cord-023439-r04y1j22	388	4	that	that	IN
cord-023439-r04y1j22	388	5	the	the	DT
cord-023439-r04y1j22	388	6	maturation	maturation	NN
cord-023439-r04y1j22	388	7	marker	marker	NN
cord-023439-r04y1j22	388	8	CD83	CD83	NNP
cord-023439-r04y1j22	388	9	and	and	CC
cord-023439-r04y1j22	388	10	the	the	DT
cord-023439-r04y1j22	388	11	costimulatory	costimulatory	NN
cord-023439-r04y1j22	388	12	molecules	molecule	NNS
cord-023439-r04y1j22	388	13	CD80	CD80	NNP
cord-023439-r04y1j22	388	14	and	and	CC
cord-023439-r04y1j22	388	15	CD86	CD86	NNP
cord-023439-r04y1j22	388	16	were	be	VBD
cord-023439-r04y1j22	388	17	upregulated	upregulate	VBN
cord-023439-r04y1j22	388	18	on	on	IN
cord-023439-r04y1j22	388	19	the	the	DT
cord-023439-r04y1j22	388	20	MDDCs	mddc	NNS
cord-023439-r04y1j22	388	21	exposed	expose	VBN
cord-023439-r04y1j22	388	22	to	to	IN
cord-023439-r04y1j22	388	23	Mala	Mala	NNP
cord-023439-r04y1j22	388	24	s	s	NNP
cord-023439-r04y1j22	388	25	11	11	CD
cord-023439-r04y1j22	388	26	for	for	IN
cord-023439-r04y1j22	388	27	24	24	CD
cord-023439-r04y1j22	388	28	h	h	NNP
cord-023439-r04y1j22	388	29	,	,	,
cord-023439-r04y1j22	388	30	as	as	IN
cord-023439-r04y1j22	388	31	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	388	32	by	by	IN
cord-023439-r04y1j22	388	33	flow	flow	NN
cord-023439-r04y1j22	388	34	cytometry	cytometry	NN
cord-023439-r04y1j22	388	35	.	.	.
cord-023439-r04y1j22	389	1	Furthermore	furthermore	RB
cord-023439-r04y1j22	389	2	,	,	,
cord-023439-r04y1j22	389	3	coculture	coculture	NN
cord-023439-r04y1j22	389	4	of	of	IN
cord-023439-r04y1j22	389	5	MDDCs	mddc	NNS
cord-023439-r04y1j22	389	6	with	with	IN
cord-023439-r04y1j22	389	7	Mala	Mala	NNP
cord-023439-r04y1j22	389	8	s	s	NNP
cord-023439-r04y1j22	389	9	11	11	CD
cord-023439-r04y1j22	389	10	for	for	IN
cord-023439-r04y1j22	389	11	9	9	CD
cord-023439-r04y1j22	389	12	h	h	NN
cord-023439-r04y1j22	389	13	induced	induce	VBD
cord-023439-r04y1j22	389	14	an	an	DT
cord-023439-r04y1j22	389	15	increased	increase	VBN
cord-023439-r04y1j22	389	16	production	production	NN
cord-023439-r04y1j22	389	17	of	of	IN
cord-023439-r04y1j22	389	18	the	the	DT
cord-023439-r04y1j22	389	19	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	389	20	cytokines	cytokine	NNS
cord-023439-r04y1j22	389	21	IL-6	IL-6	NNP
cord-023439-r04y1j22	389	22	(	(	-LRB-
cord-023439-r04y1j22	389	23	200-fold	200-fold	CD
cord-023439-r04y1j22	389	24	)	)	-RRB-
cord-023439-r04y1j22	389	25	,	,	,
cord-023439-r04y1j22	389	26	TNF	TNF	NNP
cord-023439-r04y1j22	389	27	-	-	,
cord-023439-r04y1j22	389	28	a	a	NNP
cord-023439-r04y1j22	389	29	(	(	-LRB-
cord-023439-r04y1j22	389	30	100-fold	100-fold	CD
cord-023439-r04y1j22	389	31	)	)	-RRB-
cord-023439-r04y1j22	389	32	and	and	CC
cord-023439-r04y1j22	389	33	IL-8	IL-8	NNP
cord-023439-r04y1j22	389	34	(	(	-LRB-
cord-023439-r04y1j22	389	35	sixfold	sixfold	RB
cord-023439-r04y1j22	389	36	)	)	-RRB-
cord-023439-r04y1j22	389	37	,	,	,
cord-023439-r04y1j22	389	38	as	as	IN
cord-023439-r04y1j22	389	39	detected	detect	VBN
cord-023439-r04y1j22	389	40	by	by	IN
cord-023439-r04y1j22	389	41	the	the	DT
cord-023439-r04y1j22	389	42	cytometric	cytometric	NNP
cord-023439-r04y1j22	389	43	bead	bead	NN
cord-023439-r04y1j22	389	44	array	array	NN
cord-023439-r04y1j22	389	45	(	(	-LRB-
cord-023439-r04y1j22	389	46	CBA	CBA	NNP
cord-023439-r04y1j22	389	47	)	)	-RRB-
cord-023439-r04y1j22	389	48	analysis	analysis	NN
cord-023439-r04y1j22	389	49	.	.	.
cord-023439-r04y1j22	390	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	390	2	results	result	NNS
cord-023439-r04y1j22	390	3	suggest	suggest	VBP
cord-023439-r04y1j22	390	4	that	that	IN
cord-023439-r04y1j22	390	5	Mala	Mala	NNP
cord-023439-r04y1j22	390	6	s	s	POS
cord-023439-r04y1j22	390	7	11	11	CD
cord-023439-r04y1j22	390	8	affects	affect	VBZ
cord-023439-r04y1j22	390	9	the	the	DT
cord-023439-r04y1j22	390	10	immune	immune	JJ
cord-023439-r04y1j22	390	11	response	response	NN
cord-023439-r04y1j22	390	12	through	through	IN
cord-023439-r04y1j22	390	13	DC	DC	NNP
cord-023439-r04y1j22	390	14	maturation	maturation	NN
cord-023439-r04y1j22	390	15	and	and	CC
cord-023439-r04y1j22	390	16	production	production	NN
cord-023439-r04y1j22	390	17	of	of	IN
cord-023439-r04y1j22	390	18	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	390	19	cytokines	cytokine	NNS
cord-023439-r04y1j22	390	20	.	.	.
cord-023439-r04y1j22	391	1	The	the	DT
cord-023439-r04y1j22	391	2	potential	potential	JJ
cord-023439-r04y1j22	391	3	cross	cross	NN
cord-023439-r04y1j22	391	4	-	-	NN
cord-023439-r04y1j22	391	5	reactivity	reactivity	NN
cord-023439-r04y1j22	391	6	with	with	IN
cord-023439-r04y1j22	391	7	human	human	JJ
cord-023439-r04y1j22	391	8	MnSOD	MnSOD	NNP
cord-023439-r04y1j22	391	9	needs	need	NNS
cord-023439-r04y1j22	391	10	to	to	TO
cord-023439-r04y1j22	391	11	be	be	VB
cord-023439-r04y1j22	391	12	explored	explore	VBN
cord-023439-r04y1j22	391	13	and	and	CC
cord-023439-r04y1j22	391	14	the	the	DT
cord-023439-r04y1j22	391	15	exact	exact	JJ
cord-023439-r04y1j22	391	16	role	role	NN
cord-023439-r04y1j22	391	17	of	of	IN
cord-023439-r04y1j22	391	18	Mala	Mala	NNP
cord-023439-r04y1j22	391	19	s	s	NNP
cord-023439-r04y1j22	391	20	11	11	CD
cord-023439-r04y1j22	391	21	in	in	IN
cord-023439-r04y1j22	391	22	the	the	DT
cord-023439-r04y1j22	391	23	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	391	24	of	of	IN
cord-023439-r04y1j22	391	25	AE	AE	NNP
cord-023439-r04y1j22	391	26	assessed	assess	VBN
cord-023439-r04y1j22	391	27	in	in	IN
cord-023439-r04y1j22	391	28	clinical	clinical	JJ
cord-023439-r04y1j22	391	29	studies	study	NNS
cord-023439-r04y1j22	391	30	involving	involve	VBG
cord-023439-r04y1j22	391	31	skin	skin	NN
cord-023439-r04y1j22	391	32	prick	prick	NN
cord-023439-r04y1j22	391	33	and	and	CC
cord-023439-r04y1j22	391	34	atopy	atopy	NN
cord-023439-r04y1j22	391	35	patch	patch	NN
cord-023439-r04y1j22	391	36	tests	test	NNS
cord-023439-r04y1j22	391	37	.	.	.
cord-023439-r04y1j22	392	1	Allergen	allergen	NN
cord-023439-r04y1j22	392	2	-	-	HYPH
cord-023439-r04y1j22	392	3	specific	specific	JJ
cord-023439-r04y1j22	392	4	immunotherapy	immunotherapy	NN
cord-023439-r04y1j22	392	5	(	(	-LRB-
cord-023439-r04y1j22	392	6	SIT	sit	NN
cord-023439-r04y1j22	392	7	)	)	-RRB-
cord-023439-r04y1j22	392	8	is	be	VBZ
cord-023439-r04y1j22	392	9	commonly	commonly	RB
cord-023439-r04y1j22	392	10	conducted	conduct	VBN
cord-023439-r04y1j22	392	11	with	with	IN
cord-023439-r04y1j22	392	12	allergen	allergen	NN
cord-023439-r04y1j22	392	13	extracts	extract	NNS
cord-023439-r04y1j22	392	14	adsorbed	adsorb	VBN
cord-023439-r04y1j22	392	15	to	to	IN
cord-023439-r04y1j22	392	16	aluminium	aluminium	NN
cord-023439-r04y1j22	392	17	hydroxide	hydroxide	NN
cord-023439-r04y1j22	392	18	(	(	-LRB-
cord-023439-r04y1j22	392	19	alum	alum	NN
cord-023439-r04y1j22	392	20	)	)	-RRB-
cord-023439-r04y1j22	392	21	.	.	.
cord-023439-r04y1j22	393	1	Drawbacks	drawback	NNS
cord-023439-r04y1j22	393	2	linked	link	VBN
cord-023439-r04y1j22	393	3	to	to	IN
cord-023439-r04y1j22	393	4	the	the	DT
cord-023439-r04y1j22	393	5	use	use	NN
cord-023439-r04y1j22	393	6	of	of	IN
cord-023439-r04y1j22	393	7	alum	alum	NN
cord-023439-r04y1j22	393	8	,	,	,
cord-023439-r04y1j22	393	9	such	such	JJ
cord-023439-r04y1j22	393	10	as	as	IN
cord-023439-r04y1j22	393	11	the	the	DT
cord-023439-r04y1j22	393	12	formation	formation	NN
cord-023439-r04y1j22	393	13	of	of	IN
cord-023439-r04y1j22	393	14	granuloma	granuloma	NN
cord-023439-r04y1j22	393	15	at	at	IN
cord-023439-r04y1j22	393	16	the	the	DT
cord-023439-r04y1j22	393	17	site	site	NN
cord-023439-r04y1j22	393	18	of	of	IN
cord-023439-r04y1j22	393	19	injection	injection	NN
cord-023439-r04y1j22	393	20	,	,	,
cord-023439-r04y1j22	393	21	have	have	VBP
cord-023439-r04y1j22	393	22	led	lead	VBN
cord-023439-r04y1j22	393	23	to	to	IN
cord-023439-r04y1j22	393	24	suggestions	suggestion	NNS
cord-023439-r04y1j22	393	25	of	of	IN
cord-023439-r04y1j22	393	26	novel	novel	JJ
cord-023439-r04y1j22	393	27	allergen	allergen	NN
cord-023439-r04y1j22	393	28	carriers	carrier	NNS
cord-023439-r04y1j22	393	29	.	.	.
cord-023439-r04y1j22	394	1	An	an	DT
cord-023439-r04y1j22	394	2	alternative	alternative	JJ
cord-023439-r04y1j22	394	3	carrier	carrier	NN
cord-023439-r04y1j22	394	4	is	be	VBZ
cord-023439-r04y1j22	394	5	2	2	CD
cord-023439-r04y1j22	394	6	mm	mm	NN
cord-023439-r04y1j22	394	7	carbohydrate	carbohydrate	NN
cord-023439-r04y1j22	394	8	-	-	HYPH
cord-023439-r04y1j22	394	9	based	base	VBN
cord-023439-r04y1j22	394	10	particles	particle	NNS
cord-023439-r04y1j22	394	11	(	(	-LRB-
cord-023439-r04y1j22	394	12	CBPs	CBPs	NNP
cord-023439-r04y1j22	394	13	)	)	-RRB-
cord-023439-r04y1j22	394	14	.	.	.
cord-023439-r04y1j22	395	1	In	in	IN
cord-023439-r04y1j22	395	2	mouse	mouse	NN
cord-023439-r04y1j22	395	3	,	,	,
cord-023439-r04y1j22	395	4	allergen	allergen	NN
cord-023439-r04y1j22	395	5	-	-	HYPH
cord-023439-r04y1j22	395	6	coupled	couple	VBN
cord-023439-r04y1j22	395	7	CBPs	cbp	NNS
cord-023439-r04y1j22	395	8	have	have	VBP
cord-023439-r04y1j22	395	9	been	be	VBN
cord-023439-r04y1j22	395	10	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	395	11	to	to	TO
cord-023439-r04y1j22	395	12	skew	skew	VB
cord-023439-r04y1j22	395	13	the	the	DT
cord-023439-r04y1j22	395	14	allergen	allergen	NN
cord-023439-r04y1j22	395	15	-	-	HYPH
cord-023439-r04y1j22	395	16	specific	specific	JJ
cord-023439-r04y1j22	395	17	immune	immune	JJ
cord-023439-r04y1j22	395	18	response	response	NN
cord-023439-r04y1j22	395	19	towards	towards	IN
cord-023439-r04y1j22	395	20	a	a	DT
cord-023439-r04y1j22	395	21	Th1-like	th1-like	JJ
cord-023439-r04y1j22	395	22	activity	activity	NN
cord-023439-r04y1j22	395	23	(	(	-LRB-
cord-023439-r04y1j22	395	24	Grönlund	Grönlund	NNP
cord-023439-r04y1j22	395	25	et	et	FW
cord-023439-r04y1j22	395	26	al	al	NNP
cord-023439-r04y1j22	395	27	.	.	.
cord-023439-r04y1j22	396	1	Immunology	Immunology	NNP
cord-023439-r04y1j22	396	2	,	,	,
cord-023439-r04y1j22	396	3	2002	2002	CD
cord-023439-r04y1j22	396	4	)	)	-RRB-
cord-023439-r04y1j22	396	5	.	.	.
cord-023439-r04y1j22	397	1	We	-PRON-	PRP
cord-023439-r04y1j22	397	2	here	here	RB
cord-023439-r04y1j22	397	3	coupled	couple	VBD
cord-023439-r04y1j22	397	4	the	the	DT
cord-023439-r04y1j22	397	5	recombinant	recombinant	JJ
cord-023439-r04y1j22	397	6	major	major	JJ
cord-023439-r04y1j22	397	7	cat	cat	NN
cord-023439-r04y1j22	397	8	allergen	allergen	NN
cord-023439-r04y1j22	397	9	Fel	Fel	NNP
cord-023439-r04y1j22	397	10	d	d	NNP
cord-023439-r04y1j22	397	11	1	1	CD
cord-023439-r04y1j22	397	12	to	to	IN
cord-023439-r04y1j22	397	13	CBPs	CBPs	NNP
cord-023439-r04y1j22	397	14	(	(	-LRB-
cord-023439-r04y1j22	397	15	CBP	CBP	NNP
cord-023439-r04y1j22	397	16	-	-	HYPH
cord-023439-r04y1j22	397	17	Fel	Fel	NNP
cord-023439-r04y1j22	397	18	d	d	NN
cord-023439-r04y1j22	397	19	1	1	CD
cord-023439-r04y1j22	397	20	)	)	-RRB-
cord-023439-r04y1j22	397	21	by	by	IN
cord-023439-r04y1j22	397	22	cyanogen	cyanogen	NN
cord-023439-r04y1j22	397	23	-	-	HYPH
cord-023439-r04y1j22	397	24	bromide	bromide	NN
cord-023439-r04y1j22	397	25	activation	activation	NN
cord-023439-r04y1j22	397	26	,	,	,
cord-023439-r04y1j22	397	27	resulting	result	VBG
cord-023439-r04y1j22	397	28	in	in	IN
cord-023439-r04y1j22	397	29	covalent	covalent	JJ
cord-023439-r04y1j22	397	30	binding	binding	NN
cord-023439-r04y1j22	397	31	.	.	.
cord-023439-r04y1j22	398	1	The	the	DT
cord-023439-r04y1j22	398	2	effect	effect	NN
cord-023439-r04y1j22	398	3	of	of	IN
cord-023439-r04y1j22	398	4	CBP	CBP	NNP
cord-023439-r04y1j22	398	5	-	-	HYPH
cord-023439-r04y1j22	398	6	Fel	Fel	NNP
cord-023439-r04y1j22	398	7	d	d	NNP
cord-023439-r04y1j22	398	8	1	1	CD
cord-023439-r04y1j22	398	9	on	on	IN
cord-023439-r04y1j22	398	10	monocyte	monocyte	NNP
cord-023439-r04y1j22	398	11	-	-	HYPH
cord-023439-r04y1j22	398	12	derived	derive	VBN
cord-023439-r04y1j22	398	13	dendritic	dendritic	JJ
cord-023439-r04y1j22	398	14	cells	cell	NNS
cord-023439-r04y1j22	398	15	(	(	-LRB-
cord-023439-r04y1j22	398	16	MDDCs	mddc	NNS
cord-023439-r04y1j22	398	17	)	)	-RRB-
cord-023439-r04y1j22	398	18	from	from	IN
cord-023439-r04y1j22	398	19	healthy	healthy	JJ
cord-023439-r04y1j22	398	20	human	human	JJ
cord-023439-r04y1j22	398	21	blood	blood	NN
cord-023439-r04y1j22	398	22	donors	donor	NNS
cord-023439-r04y1j22	398	23	was	be	VBD
cord-023439-r04y1j22	398	24	studied	study	VBN
cord-023439-r04y1j22	398	25	.	.	.
cord-023439-r04y1j22	399	1	We	-PRON-	PRP
cord-023439-r04y1j22	399	2	found	find	VBD
cord-023439-r04y1j22	399	3	that	that	IN
cord-023439-r04y1j22	399	4	the	the	DT
cord-023439-r04y1j22	399	5	majority	majority	NN
cord-023439-r04y1j22	399	6	of	of	IN
cord-023439-r04y1j22	399	7	the	the	DT
cord-023439-r04y1j22	399	8	CD1a	CD1a	NNP
cord-023439-r04y1j22	399	9	þ	þ	NNP
cord-023439-r04y1j22	399	10	MDDCs	mddc	NNS
cord-023439-r04y1j22	399	11	were	be	VBD
cord-023439-r04y1j22	399	12	capable	capable	JJ
cord-023439-r04y1j22	399	13	of	of	IN
cord-023439-r04y1j22	399	14	taking	take	VBG
cord-023439-r04y1j22	399	15	up	up	RP
cord-023439-r04y1j22	399	16	FITC	FITC	NNP
cord-023439-r04y1j22	399	17	-	-	HYPH
cord-023439-r04y1j22	399	18	labelled	label	VBN
cord-023439-r04y1j22	399	19	CBP	CBP	NNP
cord-023439-r04y1j22	399	20	-	-	HYPH
cord-023439-r04y1j22	399	21	Fel	Fel	NNP
cord-023439-r04y1j22	399	22	d	d	NN
cord-023439-r04y1j22	399	23	1	1	CD
cord-023439-r04y1j22	399	24	,	,	,
cord-023439-r04y1j22	399	25	as	as	IN
cord-023439-r04y1j22	399	26	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	399	27	by	by	IN
cord-023439-r04y1j22	399	28	flow	flow	NN
cord-023439-r04y1j22	399	29	cytometry	cytometry	NN
cord-023439-r04y1j22	399	30	and	and	CC
cord-023439-r04y1j22	399	31	confocal	confocal	JJ
cord-023439-r04y1j22	399	32	laser	laser	NN
cord-023439-r04y1j22	399	33	scanning	scanning	NN
cord-023439-r04y1j22	399	34	microscopy	microscopy	NNS
cord-023439-r04y1j22	399	35	.	.	.
cord-023439-r04y1j22	400	1	Furthermore	furthermore	RB
cord-023439-r04y1j22	400	2	,	,	,
cord-023439-r04y1j22	400	3	incubation	incubation	NN
cord-023439-r04y1j22	400	4	with	with	IN
cord-023439-r04y1j22	400	5	CBP	CBP	NNP
cord-023439-r04y1j22	400	6	-	-	HYPH
cord-023439-r04y1j22	400	7	Fel	Fel	NNP
cord-023439-r04y1j22	400	8	d	d	NNP
cord-023439-r04y1j22	400	9	1	1	CD
cord-023439-r04y1j22	400	10	resulted	result	VBD
cord-023439-r04y1j22	400	11	in	in	IN
cord-023439-r04y1j22	400	12	an	an	DT
cord-023439-r04y1j22	400	13	upregulation	upregulation	NN
cord-023439-r04y1j22	400	14	of	of	IN
cord-023439-r04y1j22	400	15	the	the	DT
cord-023439-r04y1j22	400	16	costimulatory	costimulatory	NN
cord-023439-r04y1j22	400	17	molecule	molecule	NN
cord-023439-r04y1j22	400	18	CD86	CD86	NNP
cord-023439-r04y1j22	400	19	on	on	IN
cord-023439-r04y1j22	400	20	the	the	DT
cord-023439-r04y1j22	400	21	MDDCs	mddc	NNS
cord-023439-r04y1j22	400	22	,	,	,
cord-023439-r04y1j22	400	23	which	which	WDT
cord-023439-r04y1j22	400	24	was	be	VBD
cord-023439-r04y1j22	400	25	not	not	RB
cord-023439-r04y1j22	400	26	observed	observe	VBN
cord-023439-r04y1j22	400	27	with	with	IN
cord-023439-r04y1j22	400	28	Fel	Fel	NNP
cord-023439-r04y1j22	400	29	d	d	NNP
cord-023439-r04y1j22	400	30	1	1	CD
cord-023439-r04y1j22	400	31	or	or	CC
cord-023439-r04y1j22	400	32	CBPs	cbps	NN
cord-023439-r04y1j22	400	33	alone	alone	RB
cord-023439-r04y1j22	400	34	.	.	.
cord-023439-r04y1j22	401	1	Finally	finally	RB
cord-023439-r04y1j22	401	2	,	,	,
cord-023439-r04y1j22	401	3	CBP	CBP	NNP
cord-023439-r04y1j22	401	4	-	-	HYPH
cord-023439-r04y1j22	401	5	Fel	Fel	NNP
cord-023439-r04y1j22	401	6	d	d	NNP
cord-023439-r04y1j22	401	7	1	1	CD
cord-023439-r04y1j22	401	8	induced	induce	VBD
cord-023439-r04y1j22	401	9	a	a	DT
cord-023439-r04y1j22	401	10	fivefold	fivefold	JJ
cord-023439-r04y1j22	401	11	increase	increase	NN
cord-023439-r04y1j22	401	12	in	in	IN
cord-023439-r04y1j22	401	13	the	the	DT
cord-023439-r04y1j22	401	14	release	release	NN
cord-023439-r04y1j22	401	15	of	of	IN
cord-023439-r04y1j22	401	16	the	the	DT
cord-023439-r04y1j22	401	17	pro	pro	JJ
cord-023439-r04y1j22	401	18	-	-	JJ
cord-023439-r04y1j22	401	19	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	401	20	cytokine	cytokine	NN
cord-023439-r04y1j22	401	21	tumour	tumour	NN
cord-023439-r04y1j22	401	22	necrosis	necrosis	NN
cord-023439-r04y1j22	401	23	factor	factor	NN
cord-023439-r04y1j22	401	24	(	(	-LRB-
cord-023439-r04y1j22	401	25	TNF)-a	TNF)-a	NNP
cord-023439-r04y1j22	401	26	and	and	CC
cord-023439-r04y1j22	401	27	a	a	DT
cord-023439-r04y1j22	401	28	fourfold	fourfold	JJ
cord-023439-r04y1j22	401	29	increase	increase	NN
cord-023439-r04y1j22	401	30	in	in	IN
cord-023439-r04y1j22	401	31	the	the	DT
cord-023439-r04y1j22	401	32	release	release	NN
cord-023439-r04y1j22	401	33	of	of	IN
cord-023439-r04y1j22	401	34	the	the	DT
cord-023439-r04y1j22	401	35	chemokine	chemokine	NN
cord-023439-r04y1j22	401	36	interleukin-8	interleukin-8	NN
cord-023439-r04y1j22	401	37	from	from	IN
cord-023439-r04y1j22	401	38	MDDCs	mddc	NNS
cord-023439-r04y1j22	401	39	.	.	.
cord-023439-r04y1j22	402	1	Taken	take	VBN
cord-023439-r04y1j22	402	2	together	together	RB
cord-023439-r04y1j22	402	3	,	,	,
cord-023439-r04y1j22	402	4	the	the	DT
cord-023439-r04y1j22	402	5	effects	effect	NNS
cord-023439-r04y1j22	402	6	CBPs	cbp	NNS
cord-023439-r04y1j22	402	7	possess	possess	VBP
cord-023439-r04y1j22	402	8	make	make	VB
cord-023439-r04y1j22	402	9	them	-PRON-	PRP
cord-023439-r04y1j22	402	10	interesting	interesting	JJ
cord-023439-r04y1j22	402	11	as	as	IN
cord-023439-r04y1j22	402	12	novel	novel	JJ
cord-023439-r04y1j22	402	13	allergen	allergen	NN
cord-023439-r04y1j22	402	14	carriers	carrier	NNS
cord-023439-r04y1j22	402	15	for	for	IN
cord-023439-r04y1j22	402	16	SIT	sit	NN
cord-023439-r04y1j22	402	17	.	.	.
cord-023439-r04y1j22	403	1	The	the	DT
cord-023439-r04y1j22	403	2	cysteine	cysteine	NN
cord-023439-r04y1j22	403	3	protease	protease	NN
cord-023439-r04y1j22	403	4	Der	Der	NNP
cord-023439-r04y1j22	403	5	p1	p1	NN
cord-023439-r04y1j22	403	6	from	from	IN
cord-023439-r04y1j22	403	7	dust	dust	NN
cord-023439-r04y1j22	403	8	mite	mite	NN
cord-023439-r04y1j22	403	9	of	of	IN
cord-023439-r04y1j22	403	10	the	the	DT
cord-023439-r04y1j22	403	11	genus	genus	NN
cord-023439-r04y1j22	403	12	Dermatophagoides	Dermatophagoides	NNP
cord-023439-r04y1j22	403	13	pteronyssinus	pteronyssinus	NNP
cord-023439-r04y1j22	403	14	is	be	VBZ
cord-023439-r04y1j22	403	15	a	a	DT
cord-023439-r04y1j22	403	16	major	major	JJ
cord-023439-r04y1j22	403	17	type	type	NN
cord-023439-r04y1j22	403	18	I	-PRON-	PRP
cord-023439-r04y1j22	403	19	allergen	allergen	NN
cord-023439-r04y1j22	403	20	.	.	.
cord-023439-r04y1j22	404	1	About	about	RB
cord-023439-r04y1j22	404	2	80	80	CD
cord-023439-r04y1j22	404	3	%	%	NN
cord-023439-r04y1j22	404	4	of	of	IN
cord-023439-r04y1j22	404	5	house	house	NN
cord-023439-r04y1j22	404	6	dust	dust	NN
cord-023439-r04y1j22	404	7	mite	mite	NNP
cord-023439-r04y1j22	404	8	(	(	-LRB-
cord-023439-r04y1j22	404	9	HDM	HDM	NNP
cord-023439-r04y1j22	404	10	)	)	-RRB-
cord-023439-r04y1j22	404	11	allergic	allergic	JJ
cord-023439-r04y1j22	404	12	individuals	individual	NNS
cord-023439-r04y1j22	404	13	are	be	VBP
cord-023439-r04y1j22	404	14	reactive	reactive	JJ
cord-023439-r04y1j22	404	15	to	to	IN
cord-023439-r04y1j22	404	16	this	this	DT
cord-023439-r04y1j22	404	17	protease	protease	NN
cord-023439-r04y1j22	404	18	in	in	IN
cord-023439-r04y1j22	404	19	standard	standard	JJ
cord-023439-r04y1j22	404	20	assays	assay	NNS
cord-023439-r04y1j22	404	21	for	for	IN
cord-023439-r04y1j22	404	22	detection	detection	NN
cord-023439-r04y1j22	404	23	of	of	IN
cord-023439-r04y1j22	404	24	IgE.	ige.	NN
cord-023439-r04y1j22	405	1	A	a	DT
cord-023439-r04y1j22	405	2	curative	curative	JJ
cord-023439-r04y1j22	405	3	treatment	treatment	NN
cord-023439-r04y1j22	405	4	for	for	IN
cord-023439-r04y1j22	405	5	atopic	atopic	JJ
cord-023439-r04y1j22	405	6	allergy	allergy	NN
cord-023439-r04y1j22	405	7	is	be	VBZ
cord-023439-r04y1j22	405	8	immunotherapy	immunotherapy	NN
cord-023439-r04y1j22	405	9	(	(	-LRB-
cord-023439-r04y1j22	405	10	IT	it	NN
cord-023439-r04y1j22	405	11	)	)	-RRB-
cord-023439-r04y1j22	405	12	with	with	IN
cord-023439-r04y1j22	405	13	HDM	HDM	NNP
cord-023439-r04y1j22	405	14	extracts	extract	NNS
cord-023439-r04y1j22	405	15	which	which	WDT
cord-023439-r04y1j22	405	16	are	be	VBP
cord-023439-r04y1j22	405	17	complex	complex	JJ
cord-023439-r04y1j22	405	18	mixtures	mixture	NNS
cord-023439-r04y1j22	405	19	occasionally	occasionally	RB
cord-023439-r04y1j22	405	20	resulting	result	VBG
cord-023439-r04y1j22	405	21	in	in	IN
cord-023439-r04y1j22	405	22	anaphylactic	anaphylactic	JJ
cord-023439-r04y1j22	405	23	reactions	reaction	NNS
cord-023439-r04y1j22	405	24	.	.	.
cord-023439-r04y1j22	406	1	Novozymes	Novozymes	NNP
cord-023439-r04y1j22	406	2	focuses	focus	VBZ
cord-023439-r04y1j22	406	3	on	on	IN
cord-023439-r04y1j22	406	4	developing	develop	VBG
cord-023439-r04y1j22	406	5	a	a	DT
cord-023439-r04y1j22	406	6	recombinant	recombinant	JJ
cord-023439-r04y1j22	406	7	variant	variant	NN
cord-023439-r04y1j22	406	8	of	of	IN
cord-023439-r04y1j22	406	9	Der	Der	NNP
cord-023439-r04y1j22	406	10	p1	p1	NNP
cord-023439-r04y1j22	406	11	which	which	WDT
cord-023439-r04y1j22	406	12	exhibit	exhibit	VBP
cord-023439-r04y1j22	406	13	lowered	lower	VBD
cord-023439-r04y1j22	406	14	risk	risk	NN
cord-023439-r04y1j22	406	15	of	of	IN
cord-023439-r04y1j22	406	16	IgE	IgE	NNP
cord-023439-r04y1j22	406	17	-	-	HYPH
cord-023439-r04y1j22	406	18	mediated	mediate	VBN
cord-023439-r04y1j22	406	19	allergic	allergic	JJ
cord-023439-r04y1j22	406	20	reactions	reaction	NNS
cord-023439-r04y1j22	406	21	,	,	,
cord-023439-r04y1j22	406	22	while	while	IN
cord-023439-r04y1j22	406	23	maintaining	maintain	VBG
cord-023439-r04y1j22	406	24	its	-PRON-	PRP$
cord-023439-r04y1j22	406	25	ability	ability	NN
cord-023439-r04y1j22	406	26	to	to	TO
cord-023439-r04y1j22	406	27	trigger	trigger	VB
cord-023439-r04y1j22	406	28	proper	proper	JJ
cord-023439-r04y1j22	406	29	Th	th	JJ
cord-023439-r04y1j22	406	30	-	-	HYPH
cord-023439-r04y1j22	406	31	cell	cell	NN
cord-023439-r04y1j22	406	32	responses	response	NNS
cord-023439-r04y1j22	406	33	.	.	.
cord-023439-r04y1j22	407	1	This	this	DT
cord-023439-r04y1j22	407	2	may	may	MD
cord-023439-r04y1j22	407	3	provide	provide	VB
cord-023439-r04y1j22	407	4	a	a	DT
cord-023439-r04y1j22	407	5	safer	safe	JJR
cord-023439-r04y1j22	407	6	alternative	alternative	NN
cord-023439-r04y1j22	407	7	for	for	IN
cord-023439-r04y1j22	407	8	specific	specific	JJ
cord-023439-r04y1j22	407	9	IT	it	NN
cord-023439-r04y1j22	407	10	of	of	IN
cord-023439-r04y1j22	407	11	HDM	HDM	NNP
cord-023439-r04y1j22	407	12	allergy	allergy	NN
cord-023439-r04y1j22	407	13	.	.	.
cord-023439-r04y1j22	408	1	A	a	DT
cord-023439-r04y1j22	408	2	secreted	secrete	VBN
cord-023439-r04y1j22	408	3	recombinant	recombinant	JJ
cord-023439-r04y1j22	408	4	form	form	NN
cord-023439-r04y1j22	408	5	of	of	IN
cord-023439-r04y1j22	408	6	pro	pro	JJ
cord-023439-r04y1j22	408	7	-	-	JJ
cord-023439-r04y1j22	408	8	Der	der	JJ
cord-023439-r04y1j22	408	9	p	p	NN
cord-023439-r04y1j22	408	10	1	1	CD
cord-023439-r04y1j22	408	11	expressed	express	VBN
cord-023439-r04y1j22	408	12	by	by	IN
cord-023439-r04y1j22	408	13	Saccharamyces	Saccharamyces	NNP
cord-023439-r04y1j22	408	14	cerevisiae	cerevisiae	NNS
cord-023439-r04y1j22	408	15	was	be	VBD
cord-023439-r04y1j22	408	16	obtained	obtain	VBN
cord-023439-r04y1j22	408	17	by	by	IN
cord-023439-r04y1j22	408	18	fusion	fusion	NN
cord-023439-r04y1j22	408	19	of	of	IN
cord-023439-r04y1j22	408	20	the	the	DT
cord-023439-r04y1j22	408	21	pro	pro	JJ
cord-023439-r04y1j22	408	22	-	-	JJ
cord-023439-r04y1j22	408	23	enzyme	enzyme	JJ
cord-023439-r04y1j22	408	24	to	to	IN
cord-023439-r04y1j22	408	25	a	a	DT
cord-023439-r04y1j22	408	26	fungal	fungal	JJ
cord-023439-r04y1j22	408	27	signal	signal	NN
cord-023439-r04y1j22	408	28	peptide	peptide	NN
cord-023439-r04y1j22	408	29	.	.	.
cord-023439-r04y1j22	409	1	The	the	DT
cord-023439-r04y1j22	409	2	N	n	CD
cord-023439-r04y1j22	409	3	-	-	HYPH
cord-023439-r04y1j22	409	4	glycosylation	glycosylation	NN
cord-023439-r04y1j22	409	5	site	site	NN
cord-023439-r04y1j22	409	6	of	of	IN
cord-023439-r04y1j22	409	7	Der	Der	NNP
cord-023439-r04y1j22	409	8	p1	p1	NNP
cord-023439-r04y1j22	409	9	was	be	VBD
cord-023439-r04y1j22	409	10	mutated	mutate	VBN
cord-023439-r04y1j22	409	11	resulting	result	VBG
cord-023439-r04y1j22	409	12	in	in	IN
cord-023439-r04y1j22	409	13	a	a	DT
cord-023439-r04y1j22	409	14	deglycosylated	deglycosylated	JJ
cord-023439-r04y1j22	409	15	pro	pro	JJ
cord-023439-r04y1j22	409	16	-	-	JJ
cord-023439-r04y1j22	409	17	enzyme	enzyme	JJ
cord-023439-r04y1j22	409	18	with	with	IN
cord-023439-r04y1j22	409	19	a	a	DT
cord-023439-r04y1j22	409	20	molecular	molecular	JJ
cord-023439-r04y1j22	409	21	mass	mass	NN
cord-023439-r04y1j22	409	22	of	of	IN
cord-023439-r04y1j22	409	23	35	35	CD
cord-023439-r04y1j22	409	24	kDa	kDa	NNS
cord-023439-r04y1j22	409	25	.	.	.
cord-023439-r04y1j22	410	1	Protein	protein	NN
cord-023439-r04y1j22	410	2	purification	purification	NN
cord-023439-r04y1j22	410	3	procedure	procedure	NN
cord-023439-r04y1j22	410	4	was	be	VBD
cord-023439-r04y1j22	410	5	developed	develop	VBN
cord-023439-r04y1j22	410	6	to	to	TO
cord-023439-r04y1j22	410	7	obtain	obtain	VB
cord-023439-r04y1j22	410	8	nearly	nearly	RB
cord-023439-r04y1j22	410	9	pure	pure	JJ
cord-023439-r04y1j22	410	10	Der	Der	NNP
cord-023439-r04y1j22	410	11	p1	p1	NNP
cord-023439-r04y1j22	410	12	protein	protein	NN
cord-023439-r04y1j22	410	13	followed	follow	VBN
cord-023439-r04y1j22	410	14	by	by	IN
cord-023439-r04y1j22	410	15	determination	determination	NN
cord-023439-r04y1j22	410	16	of	of	IN
cord-023439-r04y1j22	410	17	concentration	concentration	NN
cord-023439-r04y1j22	410	18	by	by	IN
cord-023439-r04y1j22	410	19	active	active	JJ
cord-023439-r04y1j22	410	20	-	-	HYPH
cord-023439-r04y1j22	410	21	site	site	NN
cord-023439-r04y1j22	410	22	-	-	HYPH
cord-023439-r04y1j22	410	23	titration	titration	NN
cord-023439-r04y1j22	410	24	with	with	IN
cord-023439-r04y1j22	410	25	the	the	DT
cord-023439-r04y1j22	410	26	cysteine	cysteine	NN
cord-023439-r04y1j22	410	27	protease	protease	NN
cord-023439-r04y1j22	410	28	inhibitor	inhibitor	NN
cord-023439-r04y1j22	410	29	E64	E64	NNP
cord-023439-r04y1j22	410	30	.	.	.
cord-023439-r04y1j22	411	1	The	the	DT
cord-023439-r04y1j22	411	2	deglycosylated	deglycosylated	JJ
cord-023439-r04y1j22	411	3	recombinant	recombinant	JJ
cord-023439-r04y1j22	411	4	pro	pro	JJ
cord-023439-r04y1j22	411	5	-	-	JJ
cord-023439-r04y1j22	411	6	Der	der	JJ
cord-023439-r04y1j22	411	7	p	p	NN
cord-023439-r04y1j22	411	8	1	1	CD
cord-023439-r04y1j22	411	9	revealed	reveal	VBD
cord-023439-r04y1j22	411	10	immunologic	immunologic	JJ
cord-023439-r04y1j22	411	11	similarity	similarity	NN
cord-023439-r04y1j22	411	12	to	to	IN
cord-023439-r04y1j22	411	13	the	the	DT
cord-023439-r04y1j22	411	14	native	native	JJ
cord-023439-r04y1j22	411	15	Der	Der	NNP
cord-023439-r04y1j22	411	16	p	p	NN
cord-023439-r04y1j22	411	17	1	1	CD
cord-023439-r04y1j22	411	18	molecule	molecule	NN
cord-023439-r04y1j22	411	19	when	when	WRB
cord-023439-r04y1j22	411	20	compared	compare	VBN
cord-023439-r04y1j22	411	21	in	in	IN
cord-023439-r04y1j22	411	22	basophile	basophile	JJ
cord-023439-r04y1j22	411	23	histamine	histamine	NN
cord-023439-r04y1j22	411	24	release	release	NN
cord-023439-r04y1j22	411	25	,	,	,
cord-023439-r04y1j22	411	26	IgE	ige	NN
cord-023439-r04y1j22	411	27	-	-	HYPH
cord-023439-r04y1j22	411	28	binding	bind	VBG
cord-023439-r04y1j22	411	29	assays	assay	NNS
cord-023439-r04y1j22	411	30	and	and	CC
cord-023439-r04y1j22	411	31	T	t	NN
cord-023439-r04y1j22	411	32	-	-	HYPH
cord-023439-r04y1j22	411	33	cell	cell	NN
cord-023439-r04y1j22	411	34	proliferation	proliferation	NN
cord-023439-r04y1j22	411	35	assays	assay	NNS
cord-023439-r04y1j22	411	36	.	.	.
cord-023439-r04y1j22	412	1	By	by	IN
cord-023439-r04y1j22	412	2	in	in	IN
cord-023439-r04y1j22	412	3	silico	silico	NN
cord-023439-r04y1j22	412	4	epitope	epitope	NN
cord-023439-r04y1j22	412	5	mapping	mapping	NN
cord-023439-r04y1j22	412	6	of	of	IN
cord-023439-r04y1j22	412	7	a	a	DT
cord-023439-r04y1j22	412	8	modelled	model	VBN
cord-023439-r04y1j22	412	9	3-dimensional	3-dimensional	JJ
cord-023439-r04y1j22	412	10	structure	structure	NN
cord-023439-r04y1j22	412	11	of	of	IN
cord-023439-r04y1j22	412	12	Der	Der	NNP
cord-023439-r04y1j22	412	13	p1	p1	NNP
cord-023439-r04y1j22	412	14	,	,	,
cord-023439-r04y1j22	412	15	five	five	CD
cord-023439-r04y1j22	412	16	putative	putative	JJ
cord-023439-r04y1j22	412	17	IgG	IgG	NNP
cord-023439-r04y1j22	412	18	and	and	CC
cord-023439-r04y1j22	412	19	IgE	IgE	NNP
cord-023439-r04y1j22	412	20	epitopes	epitope	NNS
cord-023439-r04y1j22	412	21	were	be	VBD
cord-023439-r04y1j22	412	22	predicted	predict	VBN
cord-023439-r04y1j22	412	23	.	.	.
cord-023439-r04y1j22	413	1	By	by	IN
cord-023439-r04y1j22	413	2	protein	protein	NN
cord-023439-r04y1j22	413	3	engineering	engineering	NN
cord-023439-r04y1j22	413	4	,	,	,
cord-023439-r04y1j22	413	5	the	the	DT
cord-023439-r04y1j22	413	6	predicted	predict	VBN
cord-023439-r04y1j22	413	7	epitopes	epitope	NNS
cord-023439-r04y1j22	413	8	were	be	VBD
cord-023439-r04y1j22	413	9	removed	remove	VBN
cord-023439-r04y1j22	413	10	one	one	CD
cord-023439-r04y1j22	413	11	by	by	IN
cord-023439-r04y1j22	413	12	one	one	CD
cord-023439-r04y1j22	413	13	in	in	IN
cord-023439-r04y1j22	413	14	Der	Der	NNP
cord-023439-r04y1j22	413	15	p1	p1	NN
cord-023439-r04y1j22	413	16	and	and	CC
cord-023439-r04y1j22	413	17	screening	screening	NN
cord-023439-r04y1j22	413	18	for	for	IN
cord-023439-r04y1j22	413	19	hypoallergenic	hypoallergenic	JJ
cord-023439-r04y1j22	413	20	variants	variant	NNS
cord-023439-r04y1j22	413	21	was	be	VBD
cord-023439-r04y1j22	413	22	performed	perform	VBN
cord-023439-r04y1j22	413	23	.	.	.
cord-023439-r04y1j22	414	1	Combining	combine	VBG
cord-023439-r04y1j22	414	2	inhaled	inhale	VBN
cord-023439-r04y1j22	414	3	long	long	RB
cord-023439-r04y1j22	414	4	-	-	HYPH
cord-023439-r04y1j22	414	5	acting	act	VBG
cord-023439-r04y1j22	414	6	b-2	b-2	NN
cord-023439-r04y1j22	414	7	agonist	agonist	NN
cord-023439-r04y1j22	414	8	(	(	-LRB-
cord-023439-r04y1j22	414	9	LABA	LABA	NNP
cord-023439-r04y1j22	414	10	)	)	-RRB-
cord-023439-r04y1j22	414	11	and	and	CC
cord-023439-r04y1j22	414	12	inhaled	inhale	VBN
cord-023439-r04y1j22	414	13	corticosteroid	corticosteroid	NNP
cord-023439-r04y1j22	414	14	(	(	-LRB-
cord-023439-r04y1j22	414	15	ICS	ICS	NNP
cord-023439-r04y1j22	414	16	)	)	-RRB-
cord-023439-r04y1j22	414	17	seems	seem	VBZ
cord-023439-r04y1j22	414	18	to	to	TO
cord-023439-r04y1j22	414	19	offer	offer	VB
cord-023439-r04y1j22	414	20	asthma	asthma	NN
cord-023439-r04y1j22	414	21	control	control	NN
cord-023439-r04y1j22	414	22	at	at	IN
cord-023439-r04y1j22	414	23	a	a	DT
cord-023439-r04y1j22	414	24	lower	low	JJR
cord-023439-r04y1j22	414	25	dose	dose	NN
cord-023439-r04y1j22	414	26	of	of	IN
cord-023439-r04y1j22	414	27	ICS	ICS	NNP
cord-023439-r04y1j22	414	28	than	than	IN
cord-023439-r04y1j22	414	29	achieved	achieve	VBN
cord-023439-r04y1j22	414	30	by	by	IN
cord-023439-r04y1j22	414	31	ICS	ICS	NNP
cord-023439-r04y1j22	414	32	alone	alone	JJ
cord-023439-r04y1j22	414	33	.	.	.
cord-023439-r04y1j22	415	1	Fine	fine	JJ
cord-023439-r04y1j22	415	2	mapping	mapping	NN
cord-023439-r04y1j22	415	3	of	of	IN
cord-023439-r04y1j22	415	4	T	t	NN
cord-023439-r04y1j22	415	5	-	-	HYPH
cord-023439-r04y1j22	415	6	cell	cell	NN
cord-023439-r04y1j22	415	7	surface	surface	NN
cord-023439-r04y1j22	415	8	markers	marker	NNS
cord-023439-r04y1j22	415	9	by	by	IN
cord-023439-r04y1j22	415	10	flow	flow	NN
cord-023439-r04y1j22	415	11	cytometry	cytometry	NN
cord-023439-r04y1j22	415	12	offers	offer	VBZ
cord-023439-r04y1j22	415	13	a	a	DT
cord-023439-r04y1j22	415	14	detailed	detailed	JJ
cord-023439-r04y1j22	415	15	status	status	NN
cord-023439-r04y1j22	415	16	of	of	IN
cord-023439-r04y1j22	415	17	the	the	DT
cord-023439-r04y1j22	415	18	individual	individual	NN
cord-023439-r04y1j22	415	19	's	's	POS
cord-023439-r04y1j22	415	20	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	415	21	response	response	NN
cord-023439-r04y1j22	415	22	.	.	.
cord-023439-r04y1j22	416	1	The	the	DT
cord-023439-r04y1j22	416	2	frequency	frequency	NN
cord-023439-r04y1j22	416	3	of	of	IN
cord-023439-r04y1j22	416	4	MT2	mt2	NN
cord-023439-r04y1j22	416	5	(	(	-LRB-
cord-023439-r04y1j22	416	6	CD4	CD4	NNP
cord-023439-r04y1j22	416	7	þ	þ	NNP
cord-023439-r04y1j22	416	8	CD45RA	cd45ra	NN
cord-023439-r04y1j22	416	9	-CD62L	-CD62L	NNP
cord-023439-r04y1j22	416	10	þ	þ	CD
cord-023439-r04y1j22	416	11	CD11adim	CD11adim	NNPS
cord-023439-r04y1j22	416	12	)	)	-RRB-
cord-023439-r04y1j22	416	13	and	and	CC
cord-023439-r04y1j22	416	14	MT1	MT1	NNP
cord-023439-r04y1j22	416	15	(	(	-LRB-
cord-023439-r04y1j22	416	16	CD4	CD4	NNP
cord-023439-r04y1j22	416	17	þ	þ	NNP
cord-023439-r04y1j22	416	18	CD45RA	cd45ra	NN
cord-023439-r04y1j22	416	19	-CD62L	-CD62L	NNP
cord-023439-r04y1j22	416	20	-CD11abright	-CD11abright	NFP
cord-023439-r04y1j22	416	21	)	)	-RRB-
cord-023439-r04y1j22	416	22	cells	cell	NNS
cord-023439-r04y1j22	416	23	in	in	IN
cord-023439-r04y1j22	416	24	peripheral	peripheral	JJ
cord-023439-r04y1j22	416	25	blood	blood	NN
cord-023439-r04y1j22	416	26	,	,	,
cord-023439-r04y1j22	416	27	and	and	CC
cord-023439-r04y1j22	416	28	their	-PRON-	PRP$
cord-023439-r04y1j22	416	29	ratio	ratio	NN
cord-023439-r04y1j22	416	30	,	,	,
cord-023439-r04y1j22	416	31	has	have	VBZ
cord-023439-r04y1j22	416	32	been	be	VBN
cord-023439-r04y1j22	416	33	shown	show	VBN
cord-023439-r04y1j22	416	34	to	to	TO
cord-023439-r04y1j22	416	35	differ	differ	VB
cord-023439-r04y1j22	416	36	predictably	predictably	RB
cord-023439-r04y1j22	416	37	in	in	IN
cord-023439-r04y1j22	416	38	atopics	atopic	NNS
cord-023439-r04y1j22	416	39	and	and	CC
cord-023439-r04y1j22	416	40	patients	patient	NNS
cord-023439-r04y1j22	416	41	with	with	IN
cord-023439-r04y1j22	416	42	leprosy	leprosy	NN
cord-023439-r04y1j22	416	43	,	,	,
cord-023439-r04y1j22	416	44	where	where	WRB
cord-023439-r04y1j22	416	45	MT2	MT2	NNP
cord-023439-r04y1j22	416	46	correlates	correlate	VBZ
cord-023439-r04y1j22	416	47	with	with	IN
cord-023439-r04y1j22	416	48	a	a	DT
cord-023439-r04y1j22	416	49	Th2	th2	CD
cord-023439-r04y1j22	416	50	phenotype	phenotype	NN
cord-023439-r04y1j22	416	51	and	and	CC
cord-023439-r04y1j22	416	52	MT1	MT1	NNP
cord-023439-r04y1j22	416	53	with	with	IN
cord-023439-r04y1j22	416	54	a	a	DT
cord-023439-r04y1j22	416	55	Th1	th1	CD
cord-023439-r04y1j22	416	56	phenotype	phenotype	NN
cord-023439-r04y1j22	416	57	.	.	.
cord-023439-r04y1j22	417	1	Stable	stable	JJ
cord-023439-r04y1j22	417	2	asthmatics	asthmatic	NNS
cord-023439-r04y1j22	417	3	,	,	,
cord-023439-r04y1j22	417	4	requiring	require	VBG
cord-023439-r04y1j22	417	5	fluticasone	fluticasone	NN
cord-023439-r04y1j22	417	6	propionate	propionate	NN
cord-023439-r04y1j22	417	7	(	(	-LRB-
cord-023439-r04y1j22	417	8	FP	FP	NNP
cord-023439-r04y1j22	417	9	)	)	-RRB-
cord-023439-r04y1j22	417	10	750	750	CD
cord-023439-r04y1j22	417	11	-	-	HYPH
cord-023439-r04y1j22	417	12	1000	1000	CD
cord-023439-r04y1j22	417	13	mg	mg	NNP
cord-023439-r04y1j22	417	14	daily	daily	JJ
cord-023439-r04y1j22	417	15	or	or	CC
cord-023439-r04y1j22	417	16	equivalent	equivalent	JJ
cord-023439-r04y1j22	417	17	,	,	,
cord-023439-r04y1j22	417	18	were	be	VBD
cord-023439-r04y1j22	417	19	randomized	randomize	VBN
cord-023439-r04y1j22	417	20	to	to	TO
cord-023439-r04y1j22	417	21	receive	receive	VB
cord-023439-r04y1j22	417	22	,	,	,
cord-023439-r04y1j22	417	23	double	double	JJ
cord-023439-r04y1j22	417	24	-	-	HYPH
cord-023439-r04y1j22	417	25	blinded	blinded	JJ
cord-023439-r04y1j22	417	26	,	,	,
cord-023439-r04y1j22	418	1	either	either	CC
cord-023439-r04y1j22	418	2	Seretide	Seretide	NNP
cord-023439-r04y1j22	418	3	1	1	CD
cord-023439-r04y1j22	418	4	[	[	-LRB-
cord-023439-r04y1j22	418	5	salmeterol	salmeterol	NN
cord-023439-r04y1j22	418	6	and	and	CC
cord-023439-r04y1j22	418	7	fluticasone	fluticasone	NN
cord-023439-r04y1j22	418	8	propionate	propionate	NNP
cord-023439-r04y1j22	418	9	(	(	-LRB-
cord-023439-r04y1j22	418	10	SFC	SFC	NNP
cord-023439-r04y1j22	418	11	,	,	,
cord-023439-r04y1j22	418	12	n	n	NN
cord-023439-r04y1j22	418	13	¼	¼	NNP
cord-023439-r04y1j22	418	14	16	16	CD
cord-023439-r04y1j22	418	15	)	)	-RRB-
cord-023439-r04y1j22	418	16	]	]	-RRB-
cord-023439-r04y1j22	419	1	50	50	CD
cord-023439-r04y1j22	419	2	mg/500	mg/500	NNS
cord-023439-r04y1j22	419	3	mg	mg	NNP
cord-023439-r04y1j22	419	4	bd	bd	NNP
cord-023439-r04y1j22	419	5	or	or	CC
cord-023439-r04y1j22	419	6	FP	FP	NNP
cord-023439-r04y1j22	420	1	500	500	CD
cord-023439-r04y1j22	420	2	mg	mg	NNP
cord-023439-r04y1j22	420	3	bd	bd	NNP
cord-023439-r04y1j22	420	4	(	(	-LRB-
cord-023439-r04y1j22	420	5	n	n	NNP
cord-023439-r04y1j22	420	6	¼	¼	NNP
cord-023439-r04y1j22	420	7	17	17	CD
cord-023439-r04y1j22	420	8	)	)	-RRB-
cord-023439-r04y1j22	420	9	.	.	.
cord-023439-r04y1j22	421	1	If	if	IN
cord-023439-r04y1j22	421	2	asthma	asthma	NN
cord-023439-r04y1j22	421	3	was	be	VBD
cord-023439-r04y1j22	421	4	controlled	control	VBN
cord-023439-r04y1j22	421	5	based	base	VBN
cord-023439-r04y1j22	421	6	on	on	IN
cord-023439-r04y1j22	421	7	lung	lung	NN
cord-023439-r04y1j22	421	8	function	function	NN
cord-023439-r04y1j22	421	9	and	and	CC
cord-023439-r04y1j22	421	10	symptoms	symptom	NNS
cord-023439-r04y1j22	421	11	at	at	IN
cord-023439-r04y1j22	421	12	clinic	clinic	NN
cord-023439-r04y1j22	421	13	visits	visit	VBZ
cord-023439-r04y1j22	421	14	every	every	DT
cord-023439-r04y1j22	421	15	6	6	CD
cord-023439-r04y1j22	421	16	weeks	week	NNS
cord-023439-r04y1j22	421	17	,	,	,
cord-023439-r04y1j22	421	18	ICS	ICS	NNP
cord-023439-r04y1j22	421	19	dose	dose	NN
cord-023439-r04y1j22	421	20	was	be	VBD
cord-023439-r04y1j22	421	21	tapered	taper	VBN
cord-023439-r04y1j22	421	22	until	until	IN
cord-023439-r04y1j22	421	23	asthma	asthma	NN
cord-023439-r04y1j22	421	24	exacerbated	exacerbate	VBD
cord-023439-r04y1j22	421	25	or	or	CC
cord-023439-r04y1j22	421	26	0	0	NFP
cord-023439-r04y1j22	421	27	mg	mg	NN
cord-023439-r04y1j22	421	28	was	be	VBD
cord-023439-r04y1j22	421	29	reached	reach	VBN
cord-023439-r04y1j22	421	30	.	.	.
cord-023439-r04y1j22	422	1	The	the	DT
cord-023439-r04y1j22	422	2	frequency	frequency	NN
cord-023439-r04y1j22	422	3	and	and	CC
cord-023439-r04y1j22	422	4	ratio	ratio	NN
cord-023439-r04y1j22	422	5	of	of	IN
cord-023439-r04y1j22	422	6	MT2	MT2	NNP
cord-023439-r04y1j22	422	7	and	and	CC
cord-023439-r04y1j22	422	8	MT1	MT1	NNP
cord-023439-r04y1j22	422	9	T	T	NNP
cord-023439-r04y1j22	422	10	cells	cell	NNS
cord-023439-r04y1j22	422	11	of	of	IN
cord-023439-r04y1j22	422	12	the	the	DT
cord-023439-r04y1j22	422	13	patients	patient	NNS
cord-023439-r04y1j22	422	14	was	be	VBD
cord-023439-r04y1j22	422	15	monitored	monitor	VBN
cord-023439-r04y1j22	422	16	at	at	IN
cord-023439-r04y1j22	422	17	6	6	CD
cord-023439-r04y1j22	422	18	week	week	NN
cord-023439-r04y1j22	422	19	intervals	interval	NNS
cord-023439-r04y1j22	422	20	.	.	.
cord-023439-r04y1j22	423	1	As	as	IN
cord-023439-r04y1j22	423	2	treatment	treatment	NN
cord-023439-r04y1j22	423	3	tapered	taper	VBN
cord-023439-r04y1j22	423	4	,	,	,
cord-023439-r04y1j22	423	5	the	the	DT
cord-023439-r04y1j22	423	6	frequency	frequency	NN
cord-023439-r04y1j22	423	7	of	of	IN
cord-023439-r04y1j22	423	8	MT2	mt2	NN
cord-023439-r04y1j22	423	9	cells	cell	NNS
cord-023439-r04y1j22	423	10	decreased	decrease	VBD
cord-023439-r04y1j22	423	11	(	(	-LRB-
cord-023439-r04y1j22	423	12	P	p	NN
cord-023439-r04y1j22	423	13	¼	¼	CD
cord-023439-r04y1j22	423	14	0038	0038	CD
cord-023439-r04y1j22	423	15	from	from	IN
cord-023439-r04y1j22	423	16	first	first	JJ
cord-023439-r04y1j22	423	17	to	to	IN
cord-023439-r04y1j22	423	18	final	final	JJ
cord-023439-r04y1j22	423	19	visit	visit	NN
cord-023439-r04y1j22	423	20	)	)	-RRB-
cord-023439-r04y1j22	423	21	,	,	,
cord-023439-r04y1j22	423	22	whereas	whereas	IN
cord-023439-r04y1j22	423	23	that	that	DT
cord-023439-r04y1j22	423	24	of	of	IN
cord-023439-r04y1j22	423	25	MT1	MT1	NNP
cord-023439-r04y1j22	423	26	cells	cell	NNS
cord-023439-r04y1j22	423	27	increased	increase	VBD
cord-023439-r04y1j22	423	28	.	.	.
cord-023439-r04y1j22	424	1	The	the	DT
cord-023439-r04y1j22	424	2	ratio	ratio	NN
cord-023439-r04y1j22	424	3	of	of	IN
cord-023439-r04y1j22	424	4	MT2	MT2	NNP
cord-023439-r04y1j22	424	5	/	/	SYM
cord-023439-r04y1j22	424	6	MT1	MT1	NNP
cord-023439-r04y1j22	424	7	decreased	decrease	VBD
cord-023439-r04y1j22	424	8	(	(	-LRB-
cord-023439-r04y1j22	424	9	P	p	NN
cord-023439-r04y1j22	424	10	¼	¼	CD
cord-023439-r04y1j22	424	11	0049	0049	CD
cord-023439-r04y1j22	424	12	from	from	IN
cord-023439-r04y1j22	424	13	first	first	JJ
cord-023439-r04y1j22	424	14	to	to	IN
cord-023439-r04y1j22	424	15	final	final	JJ
cord-023439-r04y1j22	424	16	visit	visit	NN
cord-023439-r04y1j22	424	17	)	)	-RRB-
cord-023439-r04y1j22	424	18	.	.	.
cord-023439-r04y1j22	425	1	In	in	IN
cord-023439-r04y1j22	425	2	patients	patient	NNS
cord-023439-r04y1j22	425	3	receiving	receive	VBG
cord-023439-r04y1j22	425	4	LABA	LABA	NNP
cord-023439-r04y1j22	425	5	þ	þ	NNP
cord-023439-r04y1j22	425	6	ICS	ICS	NNP
cord-023439-r04y1j22	425	7	,	,	,
cord-023439-r04y1j22	425	8	the	the	DT
cord-023439-r04y1j22	425	9	fall	fall	NN
cord-023439-r04y1j22	425	10	in	in	IN
cord-023439-r04y1j22	425	11	MT2	MT2	NNP
cord-023439-r04y1j22	425	12	/	/	SYM
cord-023439-r04y1j22	425	13	MT1	MT1	NNP
cord-023439-r04y1j22	425	14	ratio	ratio	NN
cord-023439-r04y1j22	425	15	appeared	appear	VBD
cord-023439-r04y1j22	425	16	to	to	TO
cord-023439-r04y1j22	425	17	be	be	VB
cord-023439-r04y1j22	425	18	more	more	RBR
cord-023439-r04y1j22	425	19	pronounced	pronounced	JJ
cord-023439-r04y1j22	425	20	than	than	IN
cord-023439-r04y1j22	425	21	in	in	IN
cord-023439-r04y1j22	425	22	patients	patient	NNS
cord-023439-r04y1j22	425	23	receiving	receive	VBG
cord-023439-r04y1j22	425	24	ICS	ICS	NNP
cord-023439-r04y1j22	425	25	alone	alone	JJ
cord-023439-r04y1j22	425	26	.	.	.
cord-023439-r04y1j22	426	1	Thus	thus	RB
cord-023439-r04y1j22	426	2	,	,	,
cord-023439-r04y1j22	426	3	the	the	DT
cord-023439-r04y1j22	426	4	MT2	mt2	NN
cord-023439-r04y1j22	426	5	phenotype	phenotype	NN
cord-023439-r04y1j22	426	6	may	may	MD
cord-023439-r04y1j22	426	7	be	be	VB
cord-023439-r04y1j22	426	8	associated	associate	VBN
cord-023439-r04y1j22	426	9	with	with	IN
cord-023439-r04y1j22	426	10	stable	stable	JJ
cord-023439-r04y1j22	426	11	asthma	asthma	NN
cord-023439-r04y1j22	426	12	,	,	,
cord-023439-r04y1j22	426	13	whereas	whereas	IN
cord-023439-r04y1j22	426	14	an	an	DT
cord-023439-r04y1j22	426	15	imminent	imminent	JJ
cord-023439-r04y1j22	426	16	exacerbation	exacerbation	NN
cord-023439-r04y1j22	426	17	may	may	MD
cord-023439-r04y1j22	426	18	associate	associate	VB
cord-023439-r04y1j22	426	19	with	with	IN
cord-023439-r04y1j22	426	20	an	an	DT
cord-023439-r04y1j22	426	21	increase	increase	NN
cord-023439-r04y1j22	426	22	in	in	IN
cord-023439-r04y1j22	426	23	the	the	DT
cord-023439-r04y1j22	426	24	MT1	MT1	NNP
cord-023439-r04y1j22	426	25	phenotype	phenotype	NN
cord-023439-r04y1j22	426	26	.	.	.
cord-023439-r04y1j22	427	1	LABA	LABA	NNP
cord-023439-r04y1j22	427	2	may	may	MD
cord-023439-r04y1j22	427	3	allow	allow	VB
cord-023439-r04y1j22	427	4	for	for	IN
cord-023439-r04y1j22	427	5	a	a	DT
cord-023439-r04y1j22	427	6	greater	great	JJR
cord-023439-r04y1j22	427	7	effect	effect	NN
cord-023439-r04y1j22	427	8	of	of	IN
cord-023439-r04y1j22	427	9	FP	FP	NNP
cord-023439-r04y1j22	427	10	on	on	IN
cord-023439-r04y1j22	427	11	the	the	DT
cord-023439-r04y1j22	427	12	MT	MT	NNP
cord-023439-r04y1j22	427	13	ratio	ratio	NN
cord-023439-r04y1j22	427	14	.	.	.
cord-023439-r04y1j22	428	1	Activation	activation	NN
cord-023439-r04y1j22	428	2	of	of	IN
cord-023439-r04y1j22	428	3	complement	complement	JJ
cord-023439-r04y1j22	428	4	pathways	pathway	NNS
cord-023439-r04y1j22	428	5	,	,	,
cord-023439-r04y1j22	428	6	leading	lead	VBG
cord-023439-r04y1j22	428	7	to	to	IN
cord-023439-r04y1j22	428	8	production	production	NN
cord-023439-r04y1j22	428	9	of	of	IN
cord-023439-r04y1j22	428	10	C3a	C3a	NNP
cord-023439-r04y1j22	428	11	and	and	CC
cord-023439-r04y1j22	428	12	C5a	C5a	NNP
cord-023439-r04y1j22	428	13	anaphylatoxins	anaphylatoxin	NNS
cord-023439-r04y1j22	428	14	,	,	,
cord-023439-r04y1j22	428	15	has	have	VBZ
cord-023439-r04y1j22	428	16	been	be	VBN
cord-023439-r04y1j22	428	17	postulated	postulate	VBN
cord-023439-r04y1j22	428	18	in	in	IN
cord-023439-r04y1j22	428	19	the	the	DT
cord-023439-r04y1j22	428	20	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	428	21	of	of	IN
cord-023439-r04y1j22	428	22	asthma	asthma	NN
cord-023439-r04y1j22	428	23	and	and	CC
cord-023439-r04y1j22	428	24	allergic	allergic	JJ
cord-023439-r04y1j22	428	25	airway	airway	NN
cord-023439-r04y1j22	428	26	inflammation	inflammation	NN
cord-023439-r04y1j22	428	27	.	.	.
cord-023439-r04y1j22	429	1	The	the	DT
cord-023439-r04y1j22	429	2	present	present	JJ
cord-023439-r04y1j22	429	3	study	study	NN
cord-023439-r04y1j22	429	4	was	be	VBD
cord-023439-r04y1j22	429	5	undertaken	undertake	VBN
cord-023439-r04y1j22	429	6	to	to	TO
cord-023439-r04y1j22	429	7	investigate	investigate	VB
cord-023439-r04y1j22	429	8	the	the	DT
cord-023439-r04y1j22	429	9	role	role	NN
cord-023439-r04y1j22	429	10	of	of	IN
cord-023439-r04y1j22	429	11	mannan	mannan	NNP
cord-023439-r04y1j22	429	12	-	-	HYPH
cord-023439-r04y1j22	429	13	binding	bind	VBG
cord-023439-r04y1j22	429	14	lectin	lectin	NN
cord-023439-r04y1j22	429	15	(	(	-LRB-
cord-023439-r04y1j22	429	16	MBL	MBL	NNP
cord-023439-r04y1j22	429	17	)	)	-RRB-
cord-023439-r04y1j22	429	18	,	,	,
cord-023439-r04y1j22	429	19	an	an	DT
cord-023439-r04y1j22	429	20	initiator	initiator	NN
cord-023439-r04y1j22	429	21	of	of	IN
cord-023439-r04y1j22	429	22	the	the	DT
cord-023439-r04y1j22	429	23	lectin	lectin	NN
cord-023439-r04y1j22	429	24	pathway	pathway	NN
cord-023439-r04y1j22	429	25	of	of	IN
cord-023439-r04y1j22	429	26	complement	complement	NN
cord-023439-r04y1j22	429	27	,	,	,
cord-023439-r04y1j22	429	28	in	in	IN
cord-023439-r04y1j22	429	29	asthma	asthma	NN
cord-023439-r04y1j22	429	30	and	and	CC
cord-023439-r04y1j22	429	31	allergic	allergic	JJ
cord-023439-r04y1j22	429	32	rhinitis	rhinitis	NN
cord-023439-r04y1j22	429	33	.	.	.
cord-023439-r04y1j22	430	1	MBL	MBL	NNP
cord-023439-r04y1j22	430	2	levels	level	NNS
cord-023439-r04y1j22	430	3	and	and	CC
cord-023439-r04y1j22	430	4	MBL	mbl	NN
cord-023439-r04y1j22	430	5	-	-	HYPH
cord-023439-r04y1j22	430	6	induced	induce	VBN
cord-023439-r04y1j22	430	7	complement	complement	NN
cord-023439-r04y1j22	430	8	activity	activity	NN
cord-023439-r04y1j22	430	9	were	be	VBD
cord-023439-r04y1j22	430	10	determined	determine	VBN
cord-023439-r04y1j22	430	11	in	in	IN
cord-023439-r04y1j22	430	12	19	19	CD
cord-023439-r04y1j22	430	13	patients	patient	NNS
cord-023439-r04y1j22	430	14	of	of	IN
cord-023439-r04y1j22	430	15	bronchial	bronchial	JJ
cord-023439-r04y1j22	430	16	asthma	asthma	NN
cord-023439-r04y1j22	430	17	with	with	IN
cord-023439-r04y1j22	430	18	allergic	allergic	JJ
cord-023439-r04y1j22	430	19	rhinitis	rhinitis	NN
cord-023439-r04y1j22	430	20	and	and	CC
cord-023439-r04y1j22	430	21	20	20	CD
cord-023439-r04y1j22	430	22	unrelated	unrelated	JJ
cord-023439-r04y1j22	430	23	,	,	,
cord-023439-r04y1j22	430	24	age	age	NN
cord-023439-r04y1j22	430	25	-	-	HYPH
cord-023439-r04y1j22	430	26	matched	match	VBN
cord-023439-r04y1j22	430	27	controls	control	NNS
cord-023439-r04y1j22	430	28	of	of	IN
cord-023439-r04y1j22	430	29	Indian	indian	JJ
cord-023439-r04y1j22	430	30	origin	origin	NN
cord-023439-r04y1j22	430	31	.	.	.
cord-023439-r04y1j22	431	1	MBL	MBL	NNP
cord-023439-r04y1j22	431	2	levels	level	NNS
cord-023439-r04y1j22	431	3	and	and	CC
cord-023439-r04y1j22	431	4	activity	activity	NN
cord-023439-r04y1j22	431	5	were	be	VBD
cord-023439-r04y1j22	431	6	correlated	correlate	VBN
cord-023439-r04y1j22	431	7	with	with	IN
cord-023439-r04y1j22	431	8	percent	percent	NN
cord-023439-r04y1j22	431	9	eosinophilia	eosinophilia	NN
cord-023439-r04y1j22	431	10	and	and	CC
cord-023439-r04y1j22	431	11	percent	percent	NN
cord-023439-r04y1j22	431	12	predicted	predict	VBD
cord-023439-r04y1j22	431	13	FEV1	FEV1	NNP
cord-023439-r04y1j22	431	14	values	value	NNS
cord-023439-r04y1j22	431	15	of	of	IN
cord-023439-r04y1j22	431	16	the	the	DT
cord-023439-r04y1j22	431	17	patients	patient	NNS
cord-023439-r04y1j22	431	18	.	.	.
cord-023439-r04y1j22	432	1	Association	Association	NNP
cord-023439-r04y1j22	432	2	of	of	IN
cord-023439-r04y1j22	432	3	single	single	JJ
cord-023439-r04y1j22	432	4	nucleotide	nucleotide	JJ
cord-023439-r04y1j22	432	5	polymorphisms	polymorphism	NNS
cord-023439-r04y1j22	432	6	(	(	-LRB-
cord-023439-r04y1j22	432	7	SNPs	SNPs	NNP
cord-023439-r04y1j22	432	8	)	)	-RRB-
cord-023439-r04y1j22	432	9	in	in	IN
cord-023439-r04y1j22	432	10	exon	exon	NN
cord-023439-r04y1j22	432	11	1	1	CD
cord-023439-r04y1j22	432	12	and	and	CC
cord-023439-r04y1j22	432	13	intron	intron	NN
cord-023439-r04y1j22	432	14	1	1	CD
cord-023439-r04y1j22	432	15	of	of	IN
cord-023439-r04y1j22	432	16	the	the	DT
cord-023439-r04y1j22	432	17	MBL	MBL	NNP
cord-023439-r04y1j22	432	18	with	with	IN
cord-023439-r04y1j22	432	19	the	the	DT
cord-023439-r04y1j22	432	20	disease	disease	NN
cord-023439-r04y1j22	432	21	,	,	,
cord-023439-r04y1j22	432	22	clinical	clinical	JJ
cord-023439-r04y1j22	432	23	markers	marker	NNS
cord-023439-r04y1j22	432	24	,	,	,
cord-023439-r04y1j22	432	25	MBL	MBL	NNP
cord-023439-r04y1j22	432	26	levels	level	NNS
cord-023439-r04y1j22	432	27	and	and	CC
cord-023439-r04y1j22	432	28	MBL	mbl	NN
cord-023439-r04y1j22	432	29	-	-	HYPH
cord-023439-r04y1j22	432	30	induced	induce	VBN
cord-023439-r04y1j22	432	31	complement	complement	NN
cord-023439-r04y1j22	432	32	activity	activity	NN
cord-023439-r04y1j22	432	33	was	be	VBD
cord-023439-r04y1j22	432	34	analysed	analyse	VBN
cord-023439-r04y1j22	432	35	using	use	VBG
cord-023439-r04y1j22	432	36	standard	standard	JJ
cord-023439-r04y1j22	432	37	statistical	statistical	JJ
cord-023439-r04y1j22	432	38	tools	tool	NNS
cord-023439-r04y1j22	432	39	.	.	.
cord-023439-r04y1j22	433	1	Significantly	significantly	RB
cord-023439-r04y1j22	433	2	higher	high	JJR
cord-023439-r04y1j22	433	3	MBL	MBL	NNP
cord-023439-r04y1j22	433	4	levels	level	NNS
cord-023439-r04y1j22	433	5	and	and	CC
cord-023439-r04y1j22	433	6	activity	activity	NN
cord-023439-r04y1j22	433	7	were	be	VBD
cord-023439-r04y1j22	433	8	observed	observe	VBN
cord-023439-r04y1j22	433	9	in	in	IN
cord-023439-r04y1j22	433	10	patients	patient	NNS
cord-023439-r04y1j22	433	11	of	of	IN
cord-023439-r04y1j22	433	12	bronchial	bronchial	JJ
cord-023439-r04y1j22	433	13	asthma	asthma	NN
cord-023439-r04y1j22	433	14	with	with	IN
cord-023439-r04y1j22	433	15	allergic	allergic	JJ
cord-023439-r04y1j22	433	16	rhinitis	rhinitis	NN
cord-023439-r04y1j22	433	17	as	as	IN
cord-023439-r04y1j22	433	18	compared	compare	VBN
cord-023439-r04y1j22	433	19	to	to	IN
cord-023439-r04y1j22	433	20	the	the	DT
cord-023439-r04y1j22	433	21	controls	control	NNS
cord-023439-r04y1j22	433	22	.	.	.
cord-023439-r04y1j22	434	1	We	-PRON-	PRP
cord-023439-r04y1j22	434	2	identified	identify	VBD
cord-023439-r04y1j22	434	3	five	five	CD
cord-023439-r04y1j22	434	4	SNPs	snp	NNS
cord-023439-r04y1j22	434	5	,	,	,
cord-023439-r04y1j22	434	6	of	of	IN
cord-023439-r04y1j22	434	7	which	which	WDT
cord-023439-r04y1j22	434	8	two	two	CD
cord-023439-r04y1j22	434	9	,	,	,
cord-023439-r04y1j22	434	10	A816	a816	NN
cord-023439-r04y1j22	434	11	G	g	NN
cord-023439-r04y1j22	434	12	in	in	IN
cord-023439-r04y1j22	434	13	exon	exon	NN
cord-023439-r04y1j22	434	14	1	1	CD
cord-023439-r04y1j22	434	15	and	and	CC
cord-023439-r04y1j22	434	16	G1011A	G1011A	NNP
cord-023439-r04y1j22	434	17	in	in	IN
cord-023439-r04y1j22	434	18	intron	intron	NN
cord-023439-r04y1j22	434	19	1	1	CD
cord-023439-r04y1j22	434	20	of	of	IN
cord-023439-r04y1j22	434	21	the	the	DT
cord-023439-r04y1j22	434	22	MBL	MBL	NNP
cord-023439-r04y1j22	434	23	,	,	,
cord-023439-r04y1j22	434	24	were	be	VBD
cord-023439-r04y1j22	434	25	novel	novel	JJ
cord-023439-r04y1j22	434	26	.	.	.
cord-023439-r04y1j22	435	1	SNP	SNP	NNP
cord-023439-r04y1j22	435	2	G1011A	G1011A	NNP
cord-023439-r04y1j22	435	3	was	be	VBD
cord-023439-r04y1j22	435	4	significantly	significantly	RB
cord-023439-r04y1j22	435	5	associated	associate	VBN
cord-023439-r04y1j22	435	6	with	with	IN
cord-023439-r04y1j22	435	7	the	the	DT
cord-023439-r04y1j22	435	8	disease	disease	NN
cord-023439-r04y1j22	435	9	(	(	-LRB-
cord-023439-r04y1j22	435	10	P	p	NN
cord-023439-r04y1j22	435	11	¼	¼	NNP
cord-023439-r04y1j22	435	12	0.0024	0.0024	CD
cord-023439-r04y1j22	435	13	,	,	,
cord-023439-r04y1j22	435	14	OR	or	CC
cord-023439-r04y1j22	435	15	¼	¼	CD
cord-023439-r04y1j22	435	16	5.8696	5.8696	CD
cord-023439-r04y1j22	435	17	,	,	,
cord-023439-r04y1j22	435	18	95	95	CD
cord-023439-r04y1j22	435	19	%	%	NN
cord-023439-r04y1j22	435	20	CI	ci	NN
cord-023439-r04y1j22	435	21	:	:	:
cord-023439-r04y1j22	435	22	1.7316	1.7316	CD
cord-023439-r04y1j22	435	23	<	<	XX
cord-023439-r04y1j22	435	24	OR	or	CC
cord-023439-r04y1j22	435	25	<	<	XX
cord-023439-r04y1j22	435	26	19.8963	19.8963	CD
cord-023439-r04y1j22	435	27	)	)	-RRB-
cord-023439-r04y1j22	435	28	.	.	.
cord-023439-r04y1j22	436	1	Individuals	individual	NNS
cord-023439-r04y1j22	436	2	with	with	IN
cord-023439-r04y1j22	436	3	'	'	``
cord-023439-r04y1j22	436	4	A	a	DT
cord-023439-r04y1j22	436	5	'	'	''
cord-023439-r04y1j22	436	6	allele	allele	NN
cord-023439-r04y1j22	436	7	at	at	IN
cord-023439-r04y1j22	436	8	position	position	NN
cord-023439-r04y1j22	436	9	1011	1011	CD
cord-023439-r04y1j22	436	10	showed	show	VBD
cord-023439-r04y1j22	436	11	increased	increase	VBN
cord-023439-r04y1j22	436	12	MBL	MBL	NNP
cord-023439-r04y1j22	436	13	levels	level	NNS
cord-023439-r04y1j22	436	14	,	,	,
cord-023439-r04y1j22	436	15	activity	activity	NN
cord-023439-r04y1j22	436	16	and	and	CC
cord-023439-r04y1j22	436	17	disease	disease	NN
cord-023439-r04y1j22	436	18	severity	severity	NN
cord-023439-r04y1j22	436	19	.	.	.
cord-023439-r04y1j22	437	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	437	2	results	result	NNS
cord-023439-r04y1j22	437	3	suggest	suggest	VBP
cord-023439-r04y1j22	437	4	that	that	IN
cord-023439-r04y1j22	437	5	'	'	``
cord-023439-r04y1j22	437	6	A	a	DT
cord-023439-r04y1j22	437	7	'	'	''
cord-023439-r04y1j22	437	8	allele	allele	NN
cord-023439-r04y1j22	437	9	at	at	IN
cord-023439-r04y1j22	437	10	position	position	NN
cord-023439-r04y1j22	437	11	1011	1011	CD
cord-023439-r04y1j22	437	12	leading	lead	VBG
cord-023439-r04y1j22	437	13	to	to	IN
cord-023439-r04y1j22	437	14	high	high	JJ
cord-023439-r04y1j22	437	15	MBL	MBL	NNP
cord-023439-r04y1j22	437	16	levels	level	NNS
cord-023439-r04y1j22	437	17	and	and	CC
cord-023439-r04y1j22	437	18	complement	complement	NN
cord-023439-r04y1j22	437	19	activity	activity	NN
cord-023439-r04y1j22	437	20	may	may	MD
cord-023439-r04y1j22	437	21	be	be	VB
cord-023439-r04y1j22	437	22	contributing	contribute	VBG
cord-023439-r04y1j22	437	23	to	to	IN
cord-023439-r04y1j22	437	24	the	the	DT
cord-023439-r04y1j22	437	25	severity	severity	NN
cord-023439-r04y1j22	437	26	of	of	IN
cord-023439-r04y1j22	437	27	bronchial	bronchial	JJ
cord-023439-r04y1j22	437	28	asthma	asthma	NN
cord-023439-r04y1j22	437	29	and	and	CC
cord-023439-r04y1j22	437	30	allergic	allergic	JJ
cord-023439-r04y1j22	437	31	airway	airway	NN
cord-023439-r04y1j22	437	32	inflammation	inflammation	NN
cord-023439-r04y1j22	437	33	.	.	.
cord-023439-r04y1j22	438	1	Serum	serum	NN
cord-023439-r04y1j22	438	2	resistance	resistance	NN
cord-023439-r04y1j22	438	3	of	of	IN
cord-023439-r04y1j22	438	4	Borrelia	Borrelia	NNP
cord-023439-r04y1j22	438	5	burgdorferi	burgdorferi	NN
cord-023439-r04y1j22	438	6	strains	strain	NNS
cord-023439-r04y1j22	438	7	belonging	belong	VBG
cord-023439-r04y1j22	438	8	to	to	IN
cord-023439-r04y1j22	438	9	the	the	DT
cord-023439-r04y1j22	438	10	B.	B.	NNP
cord-023439-r04y1j22	438	11	afzelii	afzelii	NNP
cord-023439-r04y1j22	438	12	and	and	CC
cord-023439-r04y1j22	438	13	B.	B.	NNP
cord-023439-r04y1j22	438	14	burgdorferi	burgdorferi	NNP
cord-023439-r04y1j22	438	15	sensu	sensu	NNP
cord-023439-r04y1j22	438	16	stricto	stricto	NNP
cord-023439-r04y1j22	438	17	genospecies	genospecies	NNP
cord-023439-r04y1j22	438	18	is	be	VBZ
cord-023439-r04y1j22	438	19	dependent	dependent	JJ
cord-023439-r04y1j22	438	20	on	on	IN
cord-023439-r04y1j22	438	21	binding	bind	VBG
cord-023439-r04y1j22	438	22	of	of	IN
cord-023439-r04y1j22	438	23	complement	complement	JJ
cord-023439-r04y1j22	438	24	inhibitor	inhibitor	NN
cord-023439-r04y1j22	438	25	factor	factor	NN
cord-023439-r04y1j22	438	26	H.	h.	NN
cord-023439-r04y1j22	439	1	We	-PRON-	PRP
cord-023439-r04y1j22	439	2	recently	recently	RB
cord-023439-r04y1j22	439	3	reported	report	VBD
cord-023439-r04y1j22	439	4	that	that	IN
cord-023439-r04y1j22	439	5	factor	factor	NN
cord-023439-r04y1j22	439	6	H	h	NN
cord-023439-r04y1j22	439	7	binding	binding	NN
cord-023439-r04y1j22	439	8	by	by	IN
cord-023439-r04y1j22	439	9	B.	B.	NNP
cord-023439-r04y1j22	439	10	burgdorferi	burgdorferi	NNP
cord-023439-r04y1j22	439	11	is	be	VBZ
cord-023439-r04y1j22	439	12	due	due	JJ
cord-023439-r04y1j22	439	13	to	to	IN
cord-023439-r04y1j22	439	14	inducible	inducible	JJ
cord-023439-r04y1j22	439	15	expression	expression	NN
cord-023439-r04y1j22	439	16	of	of	IN
cord-023439-r04y1j22	439	17	several	several	JJ
cord-023439-r04y1j22	439	18	approximately	approximately	RB
cord-023439-r04y1j22	439	19	20	20	CD
cord-023439-r04y1j22	439	20	kDa	kDa	NNS
cord-023439-r04y1j22	439	21	plasmid	plasmid	NN
cord-023439-r04y1j22	439	22	-	-	HYPH
cord-023439-r04y1j22	439	23	encoded	encode	VBN
cord-023439-r04y1j22	439	24	,	,	,
cord-023439-r04y1j22	439	25	surface	surface	NN
cord-023439-r04y1j22	439	26	-	-	HYPH
cord-023439-r04y1j22	439	27	exposed	expose	VBN
cord-023439-r04y1j22	439	28	lipoproteins	lipoprotein	NNS
cord-023439-r04y1j22	439	29	related	relate	VBN
cord-023439-r04y1j22	439	30	to	to	IN
cord-023439-r04y1j22	439	31	OspE	OspE	NNP
cord-023439-r04y1j22	439	32	(	(	-LRB-
cord-023439-r04y1j22	439	33	e.g.	e.g.	RB
cord-023439-r04y1j22	439	34	ErpA	ErpA	NNP
cord-023439-r04y1j22	439	35	,	,	,
cord-023439-r04y1j22	439	36	ErpP	ErpP	NNP
cord-023439-r04y1j22	439	37	and	and	CC
cord-023439-r04y1j22	439	38	P21	P21	NNP
cord-023439-r04y1j22	439	39	)	)	-RRB-
cord-023439-r04y1j22	439	40	.	.	.
cord-023439-r04y1j22	440	1	In	in	IN
cord-023439-r04y1j22	440	2	addition	addition	NN
cord-023439-r04y1j22	440	3	,	,	,
cord-023439-r04y1j22	440	4	a	a	DT
cord-023439-r04y1j22	440	5	second	second	JJ
cord-023439-r04y1j22	440	6	class	class	NN
cord-023439-r04y1j22	440	7	of	of	IN
cord-023439-r04y1j22	440	8	factor	factor	NN
cord-023439-r04y1j22	440	9	H	h	NN
cord-023439-r04y1j22	440	10	-	-	HYPH
cord-023439-r04y1j22	440	11	binding	bind	VBG
cord-023439-r04y1j22	440	12	proteins	protein	NNS
cord-023439-r04y1j22	440	13	of	of	IN
cord-023439-r04y1j22	440	14	approximately	approximately	RB
cord-023439-r04y1j22	440	15	27	27	CD
cord-023439-r04y1j22	440	16	-	-	SYM
cord-023439-r04y1j22	440	17	35	35	CD
cord-023439-r04y1j22	440	18	kDa	kDa	NNP
cord-023439-r04y1j22	440	19	has	have	VBZ
cord-023439-r04y1j22	440	20	been	be	VBN
cord-023439-r04y1j22	440	21	described	describe	VBN
cord-023439-r04y1j22	440	22	.	.	.
cord-023439-r04y1j22	441	1	The	the	DT
cord-023439-r04y1j22	441	2	OspE	OspE	NNP
cord-023439-r04y1j22	441	3	-	-	HYPH
cord-023439-r04y1j22	441	4	related	relate	VBN
cord-023439-r04y1j22	441	5	lipoproteins	lipoprotein	NNS
cord-023439-r04y1j22	441	6	are	be	VBP
cord-023439-r04y1j22	441	7	dramatically	dramatically	RB
cord-023439-r04y1j22	441	8	induced	induce	VBN
cord-023439-r04y1j22	441	9	by	by	IN
cord-023439-r04y1j22	441	10	B.	B.	NNP
cord-023439-r04y1j22	441	11	burgdorferi	burgdorferi	NN
cord-023439-r04y1j22	441	12	during	during	IN
cord-023439-r04y1j22	441	13	transmission	transmission	NN
cord-023439-r04y1j22	441	14	from	from	IN
cord-023439-r04y1j22	441	15	its	-PRON-	PRP$
cord-023439-r04y1j22	441	16	tick	tick	NN
cord-023439-r04y1j22	441	17	vector	vector	NN
cord-023439-r04y1j22	441	18	into	into	IN
cord-023439-r04y1j22	441	19	the	the	DT
cord-023439-r04y1j22	441	20	mammalian	mammalian	JJ
cord-023439-r04y1j22	441	21	host	host	NN
cord-023439-r04y1j22	441	22	.	.	.
cord-023439-r04y1j22	442	1	The	the	DT
cord-023439-r04y1j22	442	2	induction	induction	NN
cord-023439-r04y1j22	442	3	of	of	IN
cord-023439-r04y1j22	442	4	OspE	OspE	NNP
cord-023439-r04y1j22	442	5	-	-	HYPH
cord-023439-r04y1j22	442	6	related	relate	VBN
cord-023439-r04y1j22	442	7	lipoproteins	lipoprotein	NNS
cord-023439-r04y1j22	442	8	during	during	IN
cord-023439-r04y1j22	442	9	mammalian	mammalian	JJ
cord-023439-r04y1j22	442	10	infection	infection	NN
cord-023439-r04y1j22	442	11	may	may	MD
cord-023439-r04y1j22	442	12	play	play	VB
cord-023439-r04y1j22	442	13	a	a	DT
cord-023439-r04y1j22	442	14	key	key	JJ
cord-023439-r04y1j22	442	15	a	a	DT
cord-023439-r04y1j22	442	16	role	role	NN
cord-023439-r04y1j22	442	17	in	in	IN
cord-023439-r04y1j22	442	18	the	the	DT
cord-023439-r04y1j22	442	19	borrelial	borrelial	JJ
cord-023439-r04y1j22	442	20	evasion	evasion	NN
cord-023439-r04y1j22	442	21	of	of	IN
cord-023439-r04y1j22	442	22	the	the	DT
cord-023439-r04y1j22	442	23	host	host	NN
cord-023439-r04y1j22	442	24	's	's	POS
cord-023439-r04y1j22	442	25	immune	immune	JJ
cord-023439-r04y1j22	442	26	system	system	NN
cord-023439-r04y1j22	442	27	.	.	.
cord-023439-r04y1j22	443	1	The	the	DT
cord-023439-r04y1j22	443	2	goal	goal	NN
cord-023439-r04y1j22	443	3	of	of	IN
cord-023439-r04y1j22	443	4	the	the	DT
cord-023439-r04y1j22	443	5	present	present	JJ
cord-023439-r04y1j22	443	6	study	study	NN
cord-023439-r04y1j22	443	7	was	be	VBD
cord-023439-r04y1j22	443	8	to	to	TO
cord-023439-r04y1j22	443	9	define	define	VB
cord-023439-r04y1j22	443	10	the	the	DT
cord-023439-r04y1j22	443	11	factor	factor	NN
cord-023439-r04y1j22	443	12	H	h	NN
cord-023439-r04y1j22	443	13	-	-	HYPH
cord-023439-r04y1j22	443	14	binding	bind	VBG
cord-023439-r04y1j22	443	15	regions	region	NNS
cord-023439-r04y1j22	443	16	of	of	IN
cord-023439-r04y1j22	443	17	OspE	ospe	NN
cord-023439-r04y1j22	443	18	-	-	HYPH
cord-023439-r04y1j22	443	19	related	relate	VBN
cord-023439-r04y1j22	443	20	proteins	protein	NNS
cord-023439-r04y1j22	443	21	using	use	VBG
cord-023439-r04y1j22	443	22	mutagenesis	mutagenesis	NN
cord-023439-r04y1j22	443	23	,	,	,
cord-023439-r04y1j22	443	24	peptide	peptide	NN
cord-023439-r04y1j22	443	25	mapping	mapping	NN
cord-023439-r04y1j22	443	26	and	and	CC
cord-023439-r04y1j22	443	27	surface	surface	NN
cord-023439-r04y1j22	443	28	plasmon	plasmon	NNP
cord-023439-r04y1j22	443	29	resonance	resonance	NN
cord-023439-r04y1j22	443	30	analysis	analysis	NN
cord-023439-r04y1j22	443	31	(	(	-LRB-
cord-023439-r04y1j22	443	32	Biacore	Biacore	NNP
cord-023439-r04y1j22	443	33	)	)	-RRB-
cord-023439-r04y1j22	443	34	.	.	.
cord-023439-r04y1j22	444	1	The	the	DT
cord-023439-r04y1j22	444	2	combined	combine	VBN
cord-023439-r04y1j22	444	3	studies	study	NNS
cord-023439-r04y1j22	444	4	revealed	reveal	VBD
cord-023439-r04y1j22	444	5	that	that	IN
cord-023439-r04y1j22	444	6	the	the	DT
cord-023439-r04y1j22	444	7	C	c	NN
cord-023439-r04y1j22	444	8	-	-	HYPH
cord-023439-r04y1j22	444	9	terminal	terminal	NN
cord-023439-r04y1j22	444	10	regions	region	NNS
cord-023439-r04y1j22	444	11	of	of	IN
cord-023439-r04y1j22	444	12	both	both	CC
cord-023439-r04y1j22	444	13	human	human	JJ
cord-023439-r04y1j22	444	14	and	and	CC
cord-023439-r04y1j22	444	15	mouse	mouse	NN
cord-023439-r04y1j22	444	16	factor	factor	NN
cord-023439-r04y1j22	444	17	H	H	NNP
cord-023439-r04y1j22	444	18	(	(	-LRB-
cord-023439-r04y1j22	444	19	SCRs	SCRs	NNP
cord-023439-r04y1j22	444	20	18	18	CD
cord-023439-r04y1j22	444	21	-	-	SYM
cord-023439-r04y1j22	444	22	20	20	CD
cord-023439-r04y1j22	444	23	)	)	-RRB-
cord-023439-r04y1j22	444	24	specifically	specifically	RB
cord-023439-r04y1j22	444	25	bind	bind	VB
cord-023439-r04y1j22	444	26	to	to	IN
cord-023439-r04y1j22	444	27	OspE	OspE	NNP
cord-023439-r04y1j22	444	28	-	-	HYPH
cord-023439-r04y1j22	444	29	related	relate	VBN
cord-023439-r04y1j22	444	30	lipoproteins	lipoprotein	NNS
cord-023439-r04y1j22	444	31	.	.	.
cord-023439-r04y1j22	445	1	We	-PRON-	PRP
cord-023439-r04y1j22	445	2	also	also	RB
cord-023439-r04y1j22	445	3	found	find	VBD
cord-023439-r04y1j22	445	4	FHR-1	FHR-1	NNP
cord-023439-r04y1j22	445	5	,	,	,
cord-023439-r04y1j22	446	1	whose	whose	WP$
cord-023439-r04y1j22	446	2	C	C	NNP
cord-023439-r04y1j22	446	3	-	-	HYPH
cord-023439-r04y1j22	446	4	terminal	terminal	NN
cord-023439-r04y1j22	446	5	SCRs	scr	NNS
cord-023439-r04y1j22	446	6	3	3	CD
cord-023439-r04y1j22	446	7	-	-	SYM
cord-023439-r04y1j22	446	8	5	5	CD
cord-023439-r04y1j22	446	9	are	be	VBP
cord-023439-r04y1j22	446	10	homologous	homologous	JJ
cord-023439-r04y1j22	446	11	to	to	IN
cord-023439-r04y1j22	446	12	SCRs	scr	NNS
cord-023439-r04y1j22	446	13	18	18	CD
cord-023439-r04y1j22	446	14	-	-	SYM
cord-023439-r04y1j22	446	15	20	20	CD
cord-023439-r04y1j22	446	16	of	of	IN
cord-023439-r04y1j22	446	17	factor	factor	NN
cord-023439-r04y1j22	446	18	H	h	NN
cord-023439-r04y1j22	446	19	,	,	,
cord-023439-r04y1j22	446	20	to	to	TO
cord-023439-r04y1j22	446	21	bind	bind	VB
cord-023439-r04y1j22	446	22	to	to	IN
cord-023439-r04y1j22	446	23	OspE.	OspE.	NNP
cord-023439-r04y1j22	447	1	Peptide	peptide	NN
cord-023439-r04y1j22	447	2	mapping	mapping	NN
cord-023439-r04y1j22	447	3	revealed	reveal	VBD
cord-023439-r04y1j22	447	4	five	five	CD
cord-023439-r04y1j22	447	5	putative	putative	JJ
cord-023439-r04y1j22	447	6	regions	region	NNS
cord-023439-r04y1j22	447	7	(	(	-LRB-
cord-023439-r04y1j22	447	8	designated	designate	VBN
cord-023439-r04y1j22	447	9	I	I	NNP
cord-023439-r04y1j22	447	10	-	-	HYPH
cord-023439-r04y1j22	447	11	V	V	NNP
cord-023439-r04y1j22	447	12	)	)	-RRB-
cord-023439-r04y1j22	447	13	in	in	IN
cord-023439-r04y1j22	447	14	OspE	OspE	NNP
cord-023439-r04y1j22	447	15	that	that	WDT
cord-023439-r04y1j22	447	16	could	could	MD
cord-023439-r04y1j22	447	17	directly	directly	RB
cord-023439-r04y1j22	447	18	interact	interact	VB
cord-023439-r04y1j22	447	19	with	with	IN
cord-023439-r04y1j22	447	20	factor	factor	NN
cord-023439-r04y1j22	447	21	H.	h.	NN
cord-023439-r04y1j22	447	22	Deleting	delete	VBG
cord-023439-r04y1j22	447	23	the	the	DT
cord-023439-r04y1j22	447	24	C	C	NNP
cord-023439-r04y1j22	447	25	-	-	HYPH
cord-023439-r04y1j22	447	26	terminal	terminal	NN
cord-023439-r04y1j22	447	27	15	15	CD
cord-023439-r04y1j22	447	28	amino	amino	NN
cord-023439-r04y1j22	447	29	acid	acid	NN
cord-023439-r04y1j22	447	30	residues	residue	NNS
cord-023439-r04y1j22	447	31	from	from	IN
cord-023439-r04y1j22	447	32	region	region	NN
cord-023439-r04y1j22	447	33	V	v	NN
cord-023439-r04y1j22	447	34	of	of	IN
cord-023439-r04y1j22	447	35	P21	P21	NNP
cord-023439-r04y1j22	447	36	abolished	abolish	VBD
cord-023439-r04y1j22	447	37	its	-PRON-	PRP$
cord-023439-r04y1j22	447	38	ability	ability	NN
cord-023439-r04y1j22	447	39	to	to	TO
cord-023439-r04y1j22	447	40	bind	bind	VB
cord-023439-r04y1j22	447	41	factor	factor	NN
cord-023439-r04y1j22	447	42	H.	h.	NN
cord-023439-r04y1j22	448	1	At	at	IN
cord-023439-r04y1j22	448	2	the	the	DT
cord-023439-r04y1j22	448	3	same	same	JJ
cord-023439-r04y1j22	448	4	time	time	NN
cord-023439-r04y1j22	448	5	,	,	,
cord-023439-r04y1j22	448	6	however	however	RB
cord-023439-r04y1j22	448	7	,	,	,
cord-023439-r04y1j22	448	8	synthetic	synthetic	JJ
cord-023439-r04y1j22	448	9	peptides	peptide	NNS
cord-023439-r04y1j22	448	10	corresponding	correspond	VBG
cord-023439-r04y1j22	448	11	to	to	IN
cord-023439-r04y1j22	448	12	the	the	DT
cord-023439-r04y1j22	448	13	C	C	NNP
cord-023439-r04y1j22	448	14	-	-	HYPH
cord-023439-r04y1j22	448	15	termini	termini	NNP
cord-023439-r04y1j22	448	16	of	of	IN
cord-023439-r04y1j22	448	17	OspE	OspE	NNP
cord-023439-r04y1j22	448	18	,	,	,
cord-023439-r04y1j22	448	19	P21	P21	NNP
cord-023439-r04y1j22	448	20	and	and	CC
cord-023439-r04y1j22	448	21	ErpP	ErpP	NNP
cord-023439-r04y1j22	448	22	did	do	VBD
cord-023439-r04y1j22	448	23	not	not	RB
cord-023439-r04y1j22	448	24	inhibit	inhibit	VB
cord-023439-r04y1j22	448	25	factor	factor	NN
cord-023439-r04y1j22	448	26	H	h	NN
cord-023439-r04y1j22	448	27	binding	bind	VBG
cord-023439-r04y1j22	448	28	to	to	IN
cord-023439-r04y1j22	448	29	OspE.	ospe.	XX
cord-023439-r04y1j22	449	1	Thus	thus	RB
cord-023439-r04y1j22	449	2	,	,	,
cord-023439-r04y1j22	449	3	the	the	DT
cord-023439-r04y1j22	449	4	C	c	NN
cord-023439-r04y1j22	449	5	-	-	HYPH
cord-023439-r04y1j22	449	6	terminal	terminal	NN
cord-023439-r04y1j22	449	7	-	-	HYPH
cord-023439-r04y1j22	449	8	binding	bind	VBG
cord-023439-r04y1j22	449	9	region	region	NN
cord-023439-r04y1j22	449	10	V	v	NN
cord-023439-r04y1j22	449	11	appears	appear	VBZ
cord-023439-r04y1j22	449	12	to	to	TO
cord-023439-r04y1j22	449	13	be	be	VB
cord-023439-r04y1j22	449	14	necessary	necessary	JJ
cord-023439-r04y1j22	449	15	but	but	CC
cord-023439-r04y1j22	449	16	not	not	RB
cord-023439-r04y1j22	449	17	sufficient	sufficient	JJ
cord-023439-r04y1j22	449	18	for	for	IN
cord-023439-r04y1j22	449	19	factor	factor	NN
cord-023439-r04y1j22	449	20	H	h	NN
cord-023439-r04y1j22	449	21	binding	binding	NN
cord-023439-r04y1j22	449	22	.	.	.
cord-023439-r04y1j22	450	1	When	when	WRB
cord-023439-r04y1j22	450	2	a	a	DT
cord-023439-r04y1j22	450	3	more	more	RBR
cord-023439-r04y1j22	450	4	specific	specific	JJ
cord-023439-r04y1j22	450	5	mutation	mutation	NN
cord-023439-r04y1j22	450	6	strategy	strategy	NN
cord-023439-r04y1j22	450	7	was	be	VBD
cord-023439-r04y1j22	450	8	employed	employ	VBN
cord-023439-r04y1j22	450	9	,	,	,
cord-023439-r04y1j22	450	10	where	where	WRB
cord-023439-r04y1j22	450	11	single	single	JJ
cord-023439-r04y1j22	450	12	amino	amino	NN
cord-023439-r04y1j22	450	13	acid	acid	NN
cord-023439-r04y1j22	450	14	residues	residue	NNS
cord-023439-r04y1j22	450	15	in	in	IN
cord-023439-r04y1j22	450	16	peptides	peptide	NNS
cord-023439-r04y1j22	450	17	spanning	span	VBG
cord-023439-r04y1j22	450	18	over	over	IN
cord-023439-r04y1j22	450	19	the	the	DT
cord-023439-r04y1j22	450	20	factor	factor	NN
cord-023439-r04y1j22	450	21	H	h	NN
cord-023439-r04y1j22	450	22	-	-	HYPH
cord-023439-r04y1j22	450	23	binding	bind	VBG
cord-023439-r04y1j22	450	24	regions	region	NNS
cord-023439-r04y1j22	450	25	were	be	VBD
cord-023439-r04y1j22	450	26	mutated	mutate	VBN
cord-023439-r04y1j22	450	27	to	to	IN
cord-023439-r04y1j22	450	28	alanines	alanine	NNS
cord-023439-r04y1j22	450	29	,	,	,
cord-023439-r04y1j22	450	30	we	-PRON-	PRP
cord-023439-r04y1j22	450	31	observed	observe	VBD
cord-023439-r04y1j22	450	32	that	that	IN
cord-023439-r04y1j22	450	33	lysines	lysine	NNS
cord-023439-r04y1j22	450	34	in	in	IN
cord-023439-r04y1j22	450	35	the	the	DT
cord-023439-r04y1j22	450	36	factor	factor	NN
cord-023439-r04y1j22	450	37	H	h	NN
cord-023439-r04y1j22	450	38	-	-	HYPH
cord-023439-r04y1j22	450	39	binding	bind	VBG
cord-023439-r04y1j22	450	40	regions	region	NNS
cord-023439-r04y1j22	450	41	of	of	IN
cord-023439-r04y1j22	450	42	OspE	OspE	NNP
cord-023439-r04y1j22	450	43	were	be	VBD
cord-023439-r04y1j22	450	44	required	require	VBN
cord-023439-r04y1j22	450	45	for	for	IN
cord-023439-r04y1j22	450	46	factor	factor	NN
cord-023439-r04y1j22	450	47	H	h	NN
cord-023439-r04y1j22	450	48	binding	binding	NN
cord-023439-r04y1j22	450	49	.	.	.
cord-023439-r04y1j22	451	1	The	the	DT
cord-023439-r04y1j22	451	2	combined	combined	JJ
cord-023439-r04y1j22	451	3	data	datum	NNS
cord-023439-r04y1j22	451	4	have	have	VBP
cord-023439-r04y1j22	451	5	revealed	reveal	VBN
cord-023439-r04y1j22	451	6	that	that	IN
cord-023439-r04y1j22	451	7	key	key	JJ
cord-023439-r04y1j22	451	8	lysine	lysine	NN
cord-023439-r04y1j22	451	9	residues	residue	NNS
cord-023439-r04y1j22	451	10	in	in	IN
cord-023439-r04y1j22	451	11	OspE	OspE	NNP
cord-023439-r04y1j22	451	12	-	-	HYPH
cord-023439-r04y1j22	451	13	related	relate	VBN
cord-023439-r04y1j22	451	14	lipoproteins	lipoprotein	NNS
cord-023439-r04y1j22	451	15	and	and	CC
cord-023439-r04y1j22	451	16	ionic	ionic	JJ
cord-023439-r04y1j22	451	17	interactions	interaction	NNS
cord-023439-r04y1j22	451	18	are	be	VBP
cord-023439-r04y1j22	451	19	crucial	crucial	JJ
cord-023439-r04y1j22	451	20	for	for	IN
cord-023439-r04y1j22	451	21	factor	factor	NN
cord-023439-r04y1j22	451	22	H	h	NN
cord-023439-r04y1j22	451	23	interactions	interaction	NNS
cord-023439-r04y1j22	451	24	.	.	.
cord-023439-r04y1j22	452	1	Furthermore	furthermore	RB
cord-023439-r04y1j22	452	2	,	,	,
cord-023439-r04y1j22	452	3	binding	bind	VBG
cord-023439-r04y1j22	452	4	of	of	IN
cord-023439-r04y1j22	452	5	OspE	OspE	NNP
cord-023439-r04y1j22	452	6	to	to	IN
cord-023439-r04y1j22	452	7	the	the	DT
cord-023439-r04y1j22	452	8	C	C	NNP
cord-023439-r04y1j22	452	9	-	-	HYPH
cord-023439-r04y1j22	452	10	termini	termini	NNP
cord-023439-r04y1j22	452	11	of	of	IN
cord-023439-r04y1j22	452	12	both	both	DT
cord-023439-r04y1j22	452	13	mouse	mouse	NN
cord-023439-r04y1j22	452	14	and	and	CC
cord-023439-r04y1j22	452	15	human	human	NN
cord-023439-r04y1j22	452	16	factor	factor	NN
cord-023439-r04y1j22	453	1	H	H	NNP
cord-023439-r04y1j22	453	2	suggests	suggest	VBZ
cord-023439-r04y1j22	453	3	that	that	IN
cord-023439-r04y1j22	453	4	Borrelia	Borrelia	NNP
cord-023439-r04y1j22	453	5	spirochetes	spirochete	NNS
cord-023439-r04y1j22	453	6	utilize	utilize	VBP
cord-023439-r04y1j22	453	7	analogous	analogous	JJ
cord-023439-r04y1j22	453	8	complement	complement	NN
cord-023439-r04y1j22	453	9	resistance	resistance	NN
cord-023439-r04y1j22	453	10	mechanisms	mechanism	NNS
cord-023439-r04y1j22	453	11	in	in	IN
cord-023439-r04y1j22	453	12	both	both	DT
cord-023439-r04y1j22	453	13	rodents	rodent	NNS
cord-023439-r04y1j22	453	14	and	and	CC
cord-023439-r04y1j22	453	15	man	man	NN
cord-023439-r04y1j22	453	16	.	.	.
cord-023439-r04y1j22	454	1	In	in	IN
cord-023439-r04y1j22	454	2	Borrelia	Borrelia	NNP
cord-023439-r04y1j22	454	3	garinii	garinii	NN
cord-023439-r04y1j22	454	4	strains	strain	NNS
cord-023439-r04y1j22	454	5	,	,	,
cord-023439-r04y1j22	454	6	which	which	WDT
cord-023439-r04y1j22	454	7	in	in	IN
cord-023439-r04y1j22	454	8	in	in	IN
cord-023439-r04y1j22	454	9	vitro	vitro	FW
cord-023439-r04y1j22	454	10	analyses	analysis	NNS
cord-023439-r04y1j22	454	11	have	have	VBP
cord-023439-r04y1j22	454	12	been	be	VBN
cord-023439-r04y1j22	454	13	found	find	VBN
cord-023439-r04y1j22	454	14	to	to	TO
cord-023439-r04y1j22	454	15	be	be	VB
cord-023439-r04y1j22	454	16	sensitive	sensitive	JJ
cord-023439-r04y1j22	454	17	to	to	TO
cord-023439-r04y1j22	454	18	complement	complement	VB
cord-023439-r04y1j22	454	19	killing	killing	NN
cord-023439-r04y1j22	454	20	,	,	,
cord-023439-r04y1j22	454	21	differences	difference	NNS
cord-023439-r04y1j22	454	22	in	in	IN
cord-023439-r04y1j22	454	23	the	the	DT
cord-023439-r04y1j22	454	24	OspE	OspE	NNP
cord-023439-r04y1j22	454	25	sequences	sequence	NNS
cord-023439-r04y1j22	454	26	as	as	RB
cord-023439-r04y1j22	454	27	well	well	RB
cord-023439-r04y1j22	454	28	as	as	IN
cord-023439-r04y1j22	454	29	in	in	IN
cord-023439-r04y1j22	454	30	the	the	DT
cord-023439-r04y1j22	454	31	expression	expression	NN
cord-023439-r04y1j22	454	32	of	of	IN
cord-023439-r04y1j22	454	33	factor	factor	NN
cord-023439-r04y1j22	454	34	H	h	NN
cord-023439-r04y1j22	454	35	-	-	HYPH
cord-023439-r04y1j22	454	36	binding	bind	VBG
cord-023439-r04y1j22	454	37	proteins	protein	NNS
cord-023439-r04y1j22	454	38	may	may	MD
cord-023439-r04y1j22	454	39	account	account	VB
cord-023439-r04y1j22	454	40	for	for	IN
cord-023439-r04y1j22	454	41	their	-PRON-	PRP$
cord-023439-r04y1j22	454	42	susceptibility	susceptibility	NN
cord-023439-r04y1j22	454	43	to	to	IN
cord-023439-r04y1j22	454	44	serum	serum	NN
cord-023439-r04y1j22	454	45	lysis	lysis	NN
cord-023439-r04y1j22	454	46	.	.	.
cord-023439-r04y1j22	455	1	Role	role	NN
cord-023439-r04y1j22	455	2	of	of	IN
cord-023439-r04y1j22	455	3	YadA	YadA	NNP
cord-023439-r04y1j22	455	4	,	,	,
cord-023439-r04y1j22	455	5	Ail	Ail	NNP
cord-023439-r04y1j22	455	6	and	and	CC
cord-023439-r04y1j22	455	7	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-023439-r04y1j22	455	8	in	in	IN
cord-023439-r04y1j22	455	9	Serum	Serum	NNP
cord-023439-r04y1j22	455	10	Resistance	Resistance	NNP
cord-023439-r04y1j22	455	11	of	of	IN
cord-023439-r04y1j22	455	12	Yersinia	Yersinia	NNP
cord-023439-r04y1j22	455	13	enterocolitica	enterocolitica	NNP
cord-023439-r04y1j22	455	14	Serotype	Serotype	NNP
cord-023439-r04y1j22	456	1	O:3	O:3	NNP
cord-023439-r04y1j22	456	2	Mannan	Mannan	NNP
cord-023439-r04y1j22	456	3	-	-	HYPH
cord-023439-r04y1j22	456	4	binding	bind	VBG
cord-023439-r04y1j22	456	5	lectin	lectin	NN
cord-023439-r04y1j22	456	6	(	(	-LRB-
cord-023439-r04y1j22	456	7	MBL	MBL	NNP
cord-023439-r04y1j22	456	8	)	)	-RRB-
cord-023439-r04y1j22	456	9	,	,	,
cord-023439-r04y1j22	456	10	L	l	NN
cord-023439-r04y1j22	456	11	-	-	HYPH
cord-023439-r04y1j22	456	12	ficolin	ficolin	NNP
cord-023439-r04y1j22	456	13	and	and	CC
cord-023439-r04y1j22	456	14	H	h	NN
cord-023439-r04y1j22	456	15	-	-	HYPH
cord-023439-r04y1j22	456	16	ficolin	ficolin	NNP
cord-023439-r04y1j22	456	17	are	be	VBP
cord-023439-r04y1j22	456	18	pattern	pattern	NN
cord-023439-r04y1j22	456	19	recognition	recognition	NN
cord-023439-r04y1j22	456	20	molecules	molecule	NNS
cord-023439-r04y1j22	456	21	of	of	IN
cord-023439-r04y1j22	456	22	the	the	DT
cord-023439-r04y1j22	456	23	innate	innate	JJ
cord-023439-r04y1j22	456	24	immune	immune	JJ
cord-023439-r04y1j22	456	25	system	system	NN
cord-023439-r04y1j22	456	26	.	.	.
cord-023439-r04y1j22	457	1	We	-PRON-	PRP
cord-023439-r04y1j22	457	2	investigated	investigate	VBD
cord-023439-r04y1j22	457	3	the	the	DT
cord-023439-r04y1j22	457	4	ability	ability	NN
cord-023439-r04y1j22	457	5	of	of	IN
cord-023439-r04y1j22	457	6	these	these	DT
cord-023439-r04y1j22	457	7	molecules	molecule	NNS
cord-023439-r04y1j22	457	8	to	to	TO
cord-023439-r04y1j22	457	9	bind	bind	VB
cord-023439-r04y1j22	457	10	to	to	IN
cord-023439-r04y1j22	457	11	different	different	JJ
cord-023439-r04y1j22	457	12	serotypes	serotype	NNS
cord-023439-r04y1j22	457	13	and	and	CC
cord-023439-r04y1j22	457	14	noncapsulated	noncapsulated	JJ
cord-023439-r04y1j22	457	15	variants	variant	NNS
cord-023439-r04y1j22	457	16	of	of	IN
cord-023439-r04y1j22	457	17	Streptococcus	Streptococcus	NNP
cord-023439-r04y1j22	457	18	pneumonia	pneumonia	NN
cord-023439-r04y1j22	457	19	and	and	CC
cord-023439-r04y1j22	457	20	Staphylococcus	Staphylococcus	NNP
cord-023439-r04y1j22	457	21	aureus	aureus	NN
cord-023439-r04y1j22	457	22	.	.	.
cord-023439-r04y1j22	458	1	We	-PRON-	PRP
cord-023439-r04y1j22	458	2	found	find	VBD
cord-023439-r04y1j22	458	3	that	that	IN
cord-023439-r04y1j22	458	4	MBL	MBL	NNP
cord-023439-r04y1j22	458	5	binds	bind	VBZ
cord-023439-r04y1j22	458	6	to	to	IN
cord-023439-r04y1j22	458	7	noncapsulated	noncapsulated	NNP
cord-023439-r04y1j22	458	8	S.	S.	NNP
cord-023439-r04y1j22	458	9	aureus	aureus	NN
cord-023439-r04y1j22	458	10	strain	strain	NN
cord-023439-r04y1j22	458	11	(	(	-LRB-
cord-023439-r04y1j22	458	12	Wood	wood	NN
cord-023439-r04y1j22	458	13	)	)	-RRB-
cord-023439-r04y1j22	458	14	but	but	CC
cord-023439-r04y1j22	458	15	not	not	RB
cord-023439-r04y1j22	458	16	any	any	DT
cord-023439-r04y1j22	458	17	of	of	IN
cord-023439-r04y1j22	458	18	the	the	DT
cord-023439-r04y1j22	458	19	examined	examine	VBN
cord-023439-r04y1j22	458	20	S.	S.	NNP
cord-023439-r04y1j22	458	21	pneumoniae	pneumoniae	NN
cord-023439-r04y1j22	458	22	serotypes	serotype	NNS
cord-023439-r04y1j22	458	23	.	.	.
cord-023439-r04y1j22	459	1	L	l	NN
cord-023439-r04y1j22	459	2	-	-	HYPH
cord-023439-r04y1j22	459	3	ficolin	ficolin	NNP
cord-023439-r04y1j22	459	4	binds	bind	VBZ
cord-023439-r04y1j22	459	5	to	to	IN
cord-023439-r04y1j22	459	6	some	some	DT
cord-023439-r04y1j22	459	7	capsulated	capsulated	JJ
cord-023439-r04y1j22	459	8	S.	S.	NNP
cord-023439-r04y1j22	459	9	pneumoniae	pneumoniae	NN
cord-023439-r04y1j22	459	10	serotypes	serotype	NNS
cord-023439-r04y1j22	459	11	(	(	-LRB-
cord-023439-r04y1j22	459	12	11A	11a	NN
cord-023439-r04y1j22	459	13	,	,	,
cord-023439-r04y1j22	459	14	11D	11d	CD
cord-023439-r04y1j22	459	15	and	and	CC
cord-023439-r04y1j22	459	16	11F	11f	CD
cord-023439-r04y1j22	459	17	)	)	-RRB-
cord-023439-r04y1j22	459	18	as	as	RB
cord-023439-r04y1j22	459	19	well	well	RB
cord-023439-r04y1j22	459	20	as	as	IN
cord-023439-r04y1j22	459	21	some	some	DT
cord-023439-r04y1j22	459	22	capsulated	capsulated	JJ
cord-023439-r04y1j22	459	23	S.	S.	NNP
cord-023439-r04y1j22	459	24	aureus	aureus	NN
cord-023439-r04y1j22	459	25	serotypes	serotype	NNS
cord-023439-r04y1j22	459	26	(	(	-LRB-
cord-023439-r04y1j22	459	27	Type-1	type-1	NN
cord-023439-r04y1j22	459	28	,	,	,
cord-023439-r04y1j22	459	29	-8	-8	NNP
cord-023439-r04y1j22	459	30	,	,	,
cord-023439-r04y1j22	459	31	-9	-9	NNP
cord-023439-r04y1j22	459	32	,	,	,
cord-023439-r04y1j22	459	33	-11	-11	NNP
cord-023439-r04y1j22	459	34	and	and	CC
cord-023439-r04y1j22	459	35	-12	-12	NNP
cord-023439-r04y1j22	459	36	)	)	-RRB-
cord-023439-r04y1j22	459	37	.	.	.
cord-023439-r04y1j22	460	1	H	h	NN
cord-023439-r04y1j22	460	2	-	-	HYPH
cord-023439-r04y1j22	460	3	ficolin	ficolin	NN
cord-023439-r04y1j22	460	4	does	do	VBZ
cord-023439-r04y1j22	460	5	not	not	RB
cord-023439-r04y1j22	460	6	bind	bind	VB
cord-023439-r04y1j22	460	7	to	to	IN
cord-023439-r04y1j22	460	8	any	any	DT
cord-023439-r04y1j22	460	9	of	of	IN
cord-023439-r04y1j22	460	10	the	the	DT
cord-023439-r04y1j22	460	11	examined	examine	VBN
cord-023439-r04y1j22	460	12	S.	S.	NNP
cord-023439-r04y1j22	460	13	pneumoniae	pneumoniae	NN
cord-023439-r04y1j22	460	14	and	and	CC
cord-023439-r04y1j22	460	15	S.	S.	NNP
cord-023439-r04y1j22	460	16	aureus	aureus	NN
cord-023439-r04y1j22	460	17	serotypes	serotype	NNS
cord-023439-r04y1j22	460	18	included	include	VBN
cord-023439-r04y1j22	460	19	in	in	IN
cord-023439-r04y1j22	460	20	this	this	DT
cord-023439-r04y1j22	460	21	study	study	NN
cord-023439-r04y1j22	460	22	but	but	CC
cord-023439-r04y1j22	460	23	did	do	VBD
cord-023439-r04y1j22	460	24	bind	bind	VB
cord-023439-r04y1j22	460	25	to	to	IN
cord-023439-r04y1j22	460	26	a	a	DT
cord-023439-r04y1j22	460	27	strain	strain	NN
cord-023439-r04y1j22	460	28	of	of	IN
cord-023439-r04y1j22	460	29	Aerococcus	Aerococcus	NNP
cord-023439-r04y1j22	460	30	viridans	viridan	NNS
cord-023439-r04y1j22	460	31	.	.	.
cord-023439-r04y1j22	461	1	When	when	WRB
cord-023439-r04y1j22	461	2	bound	bind	VBN
cord-023439-r04y1j22	461	3	to	to	IN
cord-023439-r04y1j22	461	4	bacteria	bacteria	NNS
cord-023439-r04y1j22	461	5	,	,	,
cord-023439-r04y1j22	461	6	MBL	MBL	NNP
cord-023439-r04y1j22	461	7	and	and	CC
cord-023439-r04y1j22	461	8	H	H	NNP
cord-023439-r04y1j22	461	9	-	-	HYPH
cord-023439-r04y1j22	461	10	ficolin	ficolin	NNP
cord-023439-r04y1j22	461	11	initiated	initiate	VBN
cord-023439-r04y1j22	461	12	activation	activation	NN
cord-023439-r04y1j22	461	13	of	of	IN
cord-023439-r04y1j22	461	14	complement	complement	NN
cord-023439-r04y1j22	461	15	factor	factor	NN
cord-023439-r04y1j22	461	16	C4	c4	NN
cord-023439-r04y1j22	461	17	,	,	,
cord-023439-r04y1j22	461	18	whereas	whereas	IN
cord-023439-r04y1j22	461	19	L	l	NN
cord-023439-r04y1j22	461	20	-	-	HYPH
cord-023439-r04y1j22	461	21	ficolin	ficolin	NNP
cord-023439-r04y1j22	461	22	did	do	VBD
cord-023439-r04y1j22	461	23	not	not	RB
cord-023439-r04y1j22	461	24	.	.	.
cord-023439-r04y1j22	462	1	During	during	IN
cord-023439-r04y1j22	462	2	this	this	DT
cord-023439-r04y1j22	462	3	study	study	NN
cord-023439-r04y1j22	462	4	,	,	,
cord-023439-r04y1j22	462	5	quantitative	quantitative	JJ
cord-023439-r04y1j22	462	6	assays	assay	NNS
cord-023439-r04y1j22	462	7	for	for	IN
cord-023439-r04y1j22	462	8	the	the	DT
cord-023439-r04y1j22	462	9	three	three	CD
cord-023439-r04y1j22	462	10	proteins	protein	NNS
cord-023439-r04y1j22	462	11	were	be	VBD
cord-023439-r04y1j22	462	12	developed	develop	VBN
cord-023439-r04y1j22	462	13	and	and	CC
cord-023439-r04y1j22	462	14	the	the	DT
cord-023439-r04y1j22	462	15	concentration	concentration	NN
cord-023439-r04y1j22	462	16	in	in	IN
cord-023439-r04y1j22	462	17	97	97	CD
cord-023439-r04y1j22	462	18	plasma	plasma	NN
cord-023439-r04y1j22	462	19	samples	sample	NNS
cord-023439-r04y1j22	462	20	were	be	VBD
cord-023439-r04y1j22	462	21	determined	determine	VBN
cord-023439-r04y1j22	462	22	and	and	CC
cord-023439-r04y1j22	462	23	the	the	DT
cord-023439-r04y1j22	462	24	median	median	JJ
cord-023439-r04y1j22	462	25	values	value	NNS
cord-023439-r04y1j22	462	26	were	be	VBD
cord-023439-r04y1j22	462	27	estimated	estimate	VBN
cord-023439-r04y1j22	462	28	at	at	IN
cord-023439-r04y1j22	462	29	0.8	0.8	CD
cord-023439-r04y1j22	462	30	mg	mg	NN
cord-023439-r04y1j22	462	31	of	of	IN
cord-023439-r04y1j22	462	32	MBL	MBL	NNP
cord-023439-r04y1j22	462	33	/	/	SYM
cord-023439-r04y1j22	462	34	ml	ml	NNS
cord-023439-r04y1j22	462	35	,	,	,
cord-023439-r04y1j22	462	36	3.3	3.3	CD
cord-023439-r04y1j22	462	37	mg	mg	NN
cord-023439-r04y1j22	462	38	of	of	IN
cord-023439-r04y1j22	462	39	L	L	NNP
cord-023439-r04y1j22	462	40	-	-	HYPH
cord-023439-r04y1j22	462	41	ficolin	ficolin	NNP
cord-023439-r04y1j22	462	42	/	/	SYM
cord-023439-r04y1j22	462	43	ml	ml	NN
cord-023439-r04y1j22	462	44	and	and	CC
cord-023439-r04y1j22	462	45	18.4	18.4	CD
cord-023439-r04y1j22	462	46	mg	mg	NNS
cord-023439-r04y1j22	462	47	of	of	IN
cord-023439-r04y1j22	462	48	H	H	NNP
cord-023439-r04y1j22	462	49	-	-	HYPH
cord-023439-r04y1j22	462	50	ficolin/	ficolin/	NNP
cord-023439-r04y1j22	462	51	ml	ml	NN
cord-023439-r04y1j22	462	52	,	,	,
cord-023439-r04y1j22	462	53	respectively	respectively	RB
cord-023439-r04y1j22	462	54	.	.	.
cord-023439-r04y1j22	463	1	The	the	DT
cord-023439-r04y1j22	463	2	absence	absence	NN
cord-023439-r04y1j22	463	3	of	of	IN
cord-023439-r04y1j22	463	4	early	early	JJ
cord-023439-r04y1j22	463	5	complement	complement	NN
cord-023439-r04y1j22	463	6	components	component	NNS
cord-023439-r04y1j22	463	7	(	(	-LRB-
cord-023439-r04y1j22	463	8	C1	C1	NNP
cord-023439-r04y1j22	463	9	,	,	,
cord-023439-r04y1j22	463	10	C4	C4	NNP
cord-023439-r04y1j22	463	11	and	and	CC
cord-023439-r04y1j22	463	12	C2	C2	NNP
cord-023439-r04y1j22	463	13	but	but	CC
cord-023439-r04y1j22	463	14	not	not	RB
cord-023439-r04y1j22	463	15	C3	C3	NNP
cord-023439-r04y1j22	463	16	)	)	-RRB-
cord-023439-r04y1j22	463	17	is	be	VBZ
cord-023439-r04y1j22	463	18	a	a	DT
cord-023439-r04y1j22	463	19	predisposing	predisposing	JJ
cord-023439-r04y1j22	463	20	factor	factor	NN
cord-023439-r04y1j22	463	21	for	for	IN
cord-023439-r04y1j22	463	22	systemic	systemic	JJ
cord-023439-r04y1j22	463	23	lupus	lupus	NN
cord-023439-r04y1j22	463	24	erythematosus	erythematosus	NN
cord-023439-r04y1j22	463	25	(	(	-LRB-
cord-023439-r04y1j22	463	26	SLE	SLE	NNP
cord-023439-r04y1j22	463	27	)	)	-RRB-
cord-023439-r04y1j22	463	28	.	.	.
cord-023439-r04y1j22	464	1	Recently	recently	RB
cord-023439-r04y1j22	464	2	,	,	,
cord-023439-r04y1j22	464	3	we	-PRON-	PRP
cord-023439-r04y1j22	464	4	demonstrated	demonstrate	VBD
cord-023439-r04y1j22	464	5	that	that	IN
cord-023439-r04y1j22	464	6	,	,	,
cord-023439-r04y1j22	464	7	in	in	IN
cord-023439-r04y1j22	464	8	C4-deficient	c4-deficient	NN
cord-023439-r04y1j22	464	9	(	(	-LRB-
cord-023439-r04y1j22	464	10	C4	C4	NNP
cord-023439-r04y1j22	464	11	def	def	NN
cord-023439-r04y1j22	464	12	.	.	.
cord-023439-r04y1j22	464	13	)	)	-RRB-
cord-023439-r04y1j22	465	1	mice	mouse	NNS
cord-023439-r04y1j22	465	2	,	,	,
cord-023439-r04y1j22	465	3	IgM	igm	NN
cord-023439-r04y1j22	465	4	-	-	HYPH
cord-023439-r04y1j22	465	5	containing	contain	VBG
cord-023439-r04y1j22	465	6	immune	immune	JJ
cord-023439-r04y1j22	465	7	complexes	complex	NNS
cord-023439-r04y1j22	465	8	(	(	-LRB-
cord-023439-r04y1j22	465	9	IgM	IgM	NNP
cord-023439-r04y1j22	465	10	-	-	HYPH
cord-023439-r04y1j22	465	11	IC	IC	NNP
cord-023439-r04y1j22	465	12	)	)	-RRB-
cord-023439-r04y1j22	465	13	are	be	VBP
cord-023439-r04y1j22	465	14	filtered	filter	VBN
cord-023439-r04y1j22	465	15	by	by	IN
cord-023439-r04y1j22	465	16	the	the	DT
cord-023439-r04y1j22	465	17	splenic	splenic	JJ
cord-023439-r04y1j22	465	18	barrier	barrier	NN
cord-023439-r04y1j22	465	19	of	of	IN
cord-023439-r04y1j22	465	20	marginal	marginal	JJ
cord-023439-r04y1j22	465	21	zone	zone	NN
cord-023439-r04y1j22	465	22	macrophages	macrophage	NNS
cord-023439-r04y1j22	465	23	(	(	-LRB-
cord-023439-r04y1j22	465	24	MZM	MZM	NNP
cord-023439-r04y1j22	465	25	)	)	-RRB-
cord-023439-r04y1j22	465	26	,	,	,
cord-023439-r04y1j22	465	27	resulting	result	VBG
cord-023439-r04y1j22	465	28	in	in	IN
cord-023439-r04y1j22	465	29	an	an	DT
cord-023439-r04y1j22	465	30	increased	increase	VBN
cord-023439-r04y1j22	465	31	immune	immune	JJ
cord-023439-r04y1j22	465	32	response	response	NN
cord-023439-r04y1j22	465	33	against	against	IN
cord-023439-r04y1j22	465	34	antigens	antigen	NNS
cord-023439-r04y1j22	465	35	within	within	IN
cord-023439-r04y1j22	465	36	these	these	DT
cord-023439-r04y1j22	465	37	IgM	IgM	NNP
cord-023439-r04y1j22	465	38	-	-	HYPH
cord-023439-r04y1j22	465	39	IC	IC	NNP
cord-023439-r04y1j22	465	40	,	,	,
cord-023439-r04y1j22	465	41	but	but	CC
cord-023439-r04y1j22	465	42	this	this	DT
cord-023439-r04y1j22	465	43	could	could	MD
cord-023439-r04y1j22	465	44	not	not	RB
cord-023439-r04y1j22	465	45	be	be	VB
cord-023439-r04y1j22	465	46	observed	observe	VBN
cord-023439-r04y1j22	465	47	in	in	IN
cord-023439-r04y1j22	465	48	wildtype	wildtype	NN
cord-023439-r04y1j22	465	49	or	or	CC
cord-023439-r04y1j22	465	50	C3	c3	NN
cord-023439-r04y1j22	465	51	def	def	NN
cord-023439-r04y1j22	465	52	.	.	.
cord-023439-r04y1j22	466	1	mice	mouse	NNS
cord-023439-r04y1j22	466	2	.	.	.
cord-023439-r04y1j22	467	1	We	-PRON-	PRP
cord-023439-r04y1j22	467	2	hypothesized	hypothesize	VBD
cord-023439-r04y1j22	467	3	that	that	IN
cord-023439-r04y1j22	467	4	splenic	splenic	JJ
cord-023439-r04y1j22	467	5	CD11b	CD11b	NNS
cord-023439-r04y1j22	467	6	þ	þ	CD
cord-023439-r04y1j22	467	7	MZM	MZM	NNP
cord-023439-r04y1j22	467	8	play	play	VBP
cord-023439-r04y1j22	467	9	an	an	DT
cord-023439-r04y1j22	467	10	important	important	JJ
cord-023439-r04y1j22	467	11	role	role	NN
cord-023439-r04y1j22	467	12	in	in	IN
cord-023439-r04y1j22	467	13	the	the	DT
cord-023439-r04y1j22	467	14	induction	induction	NN
cord-023439-r04y1j22	467	15	of	of	IN
cord-023439-r04y1j22	467	16	autoimmunity	autoimmunity	NN
cord-023439-r04y1j22	467	17	,	,	,
cord-023439-r04y1j22	467	18	and	and	CC
cord-023439-r04y1j22	467	19	we	-PRON-	PRP
cord-023439-r04y1j22	467	20	therefore	therefore	RB
cord-023439-r04y1j22	467	21	analysed	analyse	VBD
cord-023439-r04y1j22	467	22	their	-PRON-	PRP$
cord-023439-r04y1j22	467	23	cytokine	cytokine	NN
cord-023439-r04y1j22	467	24	profile	profile	NN
cord-023439-r04y1j22	467	25	after	after	IN
cord-023439-r04y1j22	467	26	isolation	isolation	NN
cord-023439-r04y1j22	467	27	with	with	IN
cord-023439-r04y1j22	467	28	the	the	DT
cord-023439-r04y1j22	467	29	help	help	NN
cord-023439-r04y1j22	467	30	of	of	IN
cord-023439-r04y1j22	467	31	magnetic	magnetic	JJ
cord-023439-r04y1j22	467	32	antibody	antibody	NN
cord-023439-r04y1j22	467	33	cell	cell	NN
cord-023439-r04y1j22	467	34	sorting	sorting	NN
cord-023439-r04y1j22	467	35	.	.	.
cord-023439-r04y1j22	468	1	mRNA	mRNA	NNP
cord-023439-r04y1j22	468	2	was	be	VBD
cord-023439-r04y1j22	468	3	isolated	isolate	VBN
cord-023439-r04y1j22	468	4	,	,	,
cord-023439-r04y1j22	468	5	and	and	CC
cord-023439-r04y1j22	468	6	real	real	JJ
cord-023439-r04y1j22	468	7	-	-	HYPH
cord-023439-r04y1j22	468	8	time	time	NN
cord-023439-r04y1j22	468	9	PCR	PCR	NNP
cord-023439-r04y1j22	468	10	was	be	VBD
cord-023439-r04y1j22	468	11	performed	perform	VBN
cord-023439-r04y1j22	468	12	with	with	IN
cord-023439-r04y1j22	468	13	specific	specific	JJ
cord-023439-r04y1j22	468	14	primers	primer	NNS
cord-023439-r04y1j22	468	15	for	for	IN
cord-023439-r04y1j22	468	16	murine	murine	JJ
cord-023439-r04y1j22	468	17	IFN	IFN	NNP
cord-023439-r04y1j22	468	18	-	-	HYPH
cord-023439-r04y1j22	468	19	g	g	NNP
cord-023439-r04y1j22	468	20	(	(	-LRB-
cord-023439-r04y1j22	468	21	IFN	IFN	NNP
cord-023439-r04y1j22	468	22	-	-	HYPH
cord-023439-r04y1j22	468	23	g	g	NNP
cord-023439-r04y1j22	468	24	)	)	-RRB-
cord-023439-r04y1j22	468	25	,	,	,
cord-023439-r04y1j22	468	26	interleukin-12	interleukin-12	XX
cord-023439-r04y1j22	468	27	(	(	-LRB-
cord-023439-r04y1j22	468	28	IL-12	IL-12	NNP
cord-023439-r04y1j22	468	29	)	)	-RRB-
cord-023439-r04y1j22	468	30	and	and	CC
cord-023439-r04y1j22	468	31	IFN	IFN	NNP
cord-023439-r04y1j22	468	32	-	-	HYPH
cord-023439-r04y1j22	468	33	a	a	NNP
cord-023439-r04y1j22	468	34	(	(	-LRB-
cord-023439-r04y1j22	468	35	IFN	IFN	NNP
cord-023439-r04y1j22	468	36	-	-	HYPH
cord-023439-r04y1j22	468	37	a	a	NN
cord-023439-r04y1j22	468	38	)	)	-RRB-
cord-023439-r04y1j22	468	39	.	.	.
cord-023439-r04y1j22	469	1	We	-PRON-	PRP
cord-023439-r04y1j22	469	2	observe	observe	VBP
cord-023439-r04y1j22	469	3	a	a	DT
cord-023439-r04y1j22	469	4	moderate	moderate	JJ
cord-023439-r04y1j22	469	5	increase	increase	NN
cord-023439-r04y1j22	469	6	of	of	IN
cord-023439-r04y1j22	469	7	IL-12	IL-12	NNP
cord-023439-r04y1j22	469	8	and	and	CC
cord-023439-r04y1j22	469	9	IFN	IFN	NNP
cord-023439-r04y1j22	469	10	-	-	HYPH
cord-023439-r04y1j22	469	11	g	g	NNP
cord-023439-r04y1j22	469	12	mRNA	mrna	NN
cord-023439-r04y1j22	470	1	in	in	IN
cord-023439-r04y1j22	471	1	CD11b	CD11b	NNPS
cord-023439-r04y1j22	471	2	þ	þ	NNP
cord-023439-r04y1j22	471	3	cells	cell	NNS
cord-023439-r04y1j22	471	4	of	of	IN
cord-023439-r04y1j22	471	5	C4	c4	NN
cord-023439-r04y1j22	471	6	def	def	NN
cord-023439-r04y1j22	471	7	.	.	.
cord-023439-r04y1j22	472	1	mice	mouse	NNS
cord-023439-r04y1j22	472	2	compared	compare	VBN
cord-023439-r04y1j22	472	3	to	to	IN
cord-023439-r04y1j22	472	4	wildtype	wildtype	NN
cord-023439-r04y1j22	472	5	cells	cell	NNS
cord-023439-r04y1j22	472	6	.	.	.
cord-023439-r04y1j22	473	1	Surprisingly	surprisingly	RB
cord-023439-r04y1j22	473	2	,	,	,
cord-023439-r04y1j22	473	3	the	the	DT
cord-023439-r04y1j22	473	4	concentration	concentration	NN
cord-023439-r04y1j22	473	5	of	of	IN
cord-023439-r04y1j22	473	6	IFN	IFN	NNP
cord-023439-r04y1j22	473	7	-	-	:
cord-023439-r04y1j22	473	8	a	a	DT
cord-023439-r04y1j22	473	9	mRNA	mrna	NN
cord-023439-r04y1j22	473	10	is	be	VBZ
cord-023439-r04y1j22	473	11	six	six	CD
cord-023439-r04y1j22	473	12	times	time	NNS
cord-023439-r04y1j22	473	13	higher	high	JJR
cord-023439-r04y1j22	473	14	in	in	IN
cord-023439-r04y1j22	473	15	C4	c4	NN
cord-023439-r04y1j22	473	16	def	def	NN
cord-023439-r04y1j22	473	17	.	.	.
cord-023439-r04y1j22	474	1	mice	mouse	NNS
cord-023439-r04y1j22	474	2	.	.	.
cord-023439-r04y1j22	475	1	Preliminary	preliminary	JJ
cord-023439-r04y1j22	475	2	results	result	NNS
cord-023439-r04y1j22	475	3	suggest	suggest	VBP
cord-023439-r04y1j22	475	4	that	that	IN
cord-023439-r04y1j22	475	5	mRNA	mrna	NN
cord-023439-r04y1j22	475	6	in	in	IN
cord-023439-r04y1j22	475	7	CD11b	CD11b	NNS
cord-023439-r04y1j22	475	8	þ	þ	NNP
cord-023439-r04y1j22	475	9	cells	cell	NNS
cord-023439-r04y1j22	475	10	of	of	IN
cord-023439-r04y1j22	475	11	C3	c3	NN
cord-023439-r04y1j22	475	12	def	def	NN
cord-023439-r04y1j22	475	13	.	.	.
cord-023439-r04y1j22	476	1	mice	mice	NN
cord-023439-r04y1j22	476	2	is	be	VBZ
cord-023439-r04y1j22	476	3	even	even	RB
cord-023439-r04y1j22	476	4	lower	low	JJR
cord-023439-r04y1j22	476	5	than	than	IN
cord-023439-r04y1j22	476	6	that	that	DT
cord-023439-r04y1j22	476	7	in	in	IN
cord-023439-r04y1j22	476	8	wt	wt	NN
cord-023439-r04y1j22	476	9	.	.	.
cord-023439-r04y1j22	477	1	Six	six	CD
cord-023439-r04y1j22	477	2	hours	hour	NNS
cord-023439-r04y1j22	477	3	following	follow	VBG
cord-023439-r04y1j22	477	4	i.v	i.v	NNP
cord-023439-r04y1j22	477	5	.	.	NNP
cord-023439-r04y1j22	477	6	application	application	NN
cord-023439-r04y1j22	477	7	of	of	IN
cord-023439-r04y1j22	477	8	20	20	CD
cord-023439-r04y1j22	477	9	mg	mg	NNS
cord-023439-r04y1j22	477	10	of	of	IN
cord-023439-r04y1j22	477	11	a	a	DT
cord-023439-r04y1j22	477	12	Abstracts	Abstracts	NNPS
cord-023439-r04y1j22	477	13	625	625	CD
cord-023439-r04y1j22	477	14	..................................................................................................................................................................................................	..................................................................................................................................................................................................	.
cord-023439-r04y1j22	478	1	murine	murine	JJ
cord-023439-r04y1j22	478	2	monoclonal	monoclonal	NNP
cord-023439-r04y1j22	478	3	IgM	IgM	NNP
cord-023439-r04y1j22	478	4	anti	anti	JJ
cord-023439-r04y1j22	478	5	-	-	JJ
cord-023439-r04y1j22	478	6	dsDNA	dsdna	JJ
cord-023439-r04y1j22	478	7	antibody	antibody	NN
cord-023439-r04y1j22	478	8	,	,	,
cord-023439-r04y1j22	478	9	production	production	NN
cord-023439-r04y1j22	478	10	of	of	IN
cord-023439-r04y1j22	478	11	IL-12	IL-12	NNP
cord-023439-r04y1j22	478	12	,	,	,
cord-023439-r04y1j22	478	13	IFN	IFN	NNP
cord-023439-r04y1j22	478	14	-	-	HYPH
cord-023439-r04y1j22	478	15	g	g	NNP
cord-023439-r04y1j22	478	16	and	and	CC
cord-023439-r04y1j22	478	17	IFN-	IFN-	NNP
cord-023439-r04y1j22	479	1	a	a	DT
cord-023439-r04y1j22	479	2	mRNA	mrna	NN
cord-023439-r04y1j22	479	3	is	be	VBZ
cord-023439-r04y1j22	479	4	increased	increase	VBN
cord-023439-r04y1j22	479	5	in	in	IN
cord-023439-r04y1j22	479	6	CD11b	CD11b	NNS
cord-023439-r04y1j22	479	7	þ	þ	NNP
cord-023439-r04y1j22	479	8	cells	cell	NNS
cord-023439-r04y1j22	479	9	of	of	IN
cord-023439-r04y1j22	479	10	both	both	DT
cord-023439-r04y1j22	479	11	C4	c4	NN
cord-023439-r04y1j22	479	12	def	def	NN
cord-023439-r04y1j22	479	13	.	.	.
cord-023439-r04y1j22	480	1	and	and	CC
cord-023439-r04y1j22	480	2	wt	wt	NN
cord-023439-r04y1j22	480	3	mice	mouse	NNS
cord-023439-r04y1j22	480	4	.	.	.
cord-023439-r04y1j22	481	1	Several	several	JJ
cord-023439-r04y1j22	481	2	references	reference	NNS
cord-023439-r04y1j22	481	3	described	describe	VBN
cord-023439-r04y1j22	481	4	increased	increase	VBN
cord-023439-r04y1j22	481	5	levels	level	NNS
cord-023439-r04y1j22	481	6	of	of	IN
cord-023439-r04y1j22	481	7	INF	inf	NN
cord-023439-r04y1j22	481	8	-	-	,
cord-023439-r04y1j22	481	9	a	a	NN
cord-023439-r04y1j22	481	10	in	in	IN
cord-023439-r04y1j22	481	11	patients	patient	NNS
cord-023439-r04y1j22	481	12	with	with	IN
cord-023439-r04y1j22	481	13	SLE	SLE	NNP
cord-023439-r04y1j22	481	14	.	.	.
cord-023439-r04y1j22	482	1	Dendritic	dendritic	JJ
cord-023439-r04y1j22	482	2	cells	cell	NNS
cord-023439-r04y1j22	482	3	are	be	VBP
cord-023439-r04y1j22	482	4	discussed	discuss	VBN
cord-023439-r04y1j22	482	5	as	as	IN
cord-023439-r04y1j22	482	6	a	a	DT
cord-023439-r04y1j22	482	7	major	major	JJ
cord-023439-r04y1j22	482	8	source	source	NN
cord-023439-r04y1j22	482	9	of	of	IN
cord-023439-r04y1j22	482	10	IFN	IFN	NNP
cord-023439-r04y1j22	482	11	-	-	HYPH
cord-023439-r04y1j22	482	12	a	a	NN
cord-023439-r04y1j22	482	13	.	.	.
cord-023439-r04y1j22	483	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	483	2	observation	observation	NN
cord-023439-r04y1j22	483	3	that	that	IN
cord-023439-r04y1j22	483	4	C4-deficient	c4-deficient	NN
cord-023439-r04y1j22	483	5	,	,	,
cord-023439-r04y1j22	483	6	SLE	sle	NN
cord-023439-r04y1j22	483	7	-	-	HYPH
cord-023439-r04y1j22	483	8	susceptible	susceptible	JJ
cord-023439-r04y1j22	483	9	mice	mouse	NNS
cord-023439-r04y1j22	483	10	demonstrate	demonstrate	VBP
cord-023439-r04y1j22	483	11	an	an	DT
cord-023439-r04y1j22	483	12	increased	increase	VBN
cord-023439-r04y1j22	483	13	spontaneous	spontaneous	JJ
cord-023439-r04y1j22	483	14	IFN	IFN	NNP
cord-023439-r04y1j22	483	15	-	-	:
cord-023439-r04y1j22	483	16	a	a	DT
cord-023439-r04y1j22	483	17	production	production	NN
cord-023439-r04y1j22	483	18	by	by	IN
cord-023439-r04y1j22	483	19	splenic	splenic	JJ
cord-023439-r04y1j22	483	20	CD11b	CD11b	NNPS
cord-023439-r04y1j22	483	21	þ	þ	NNP
cord-023439-r04y1j22	483	22	marginal	marginal	JJ
cord-023439-r04y1j22	483	23	zone	zone	NN
cord-023439-r04y1j22	483	24	macrophages	macrophage	NNS
cord-023439-r04y1j22	483	25	could	could	MD
cord-023439-r04y1j22	483	26	be	be	VB
cord-023439-r04y1j22	483	27	an	an	DT
cord-023439-r04y1j22	483	28	early	early	JJ
cord-023439-r04y1j22	483	29	sign	sign	NN
cord-023439-r04y1j22	483	30	and	and	CC
cord-023439-r04y1j22	483	31	a	a	DT
cord-023439-r04y1j22	483	32	trigger	trigger	NN
cord-023439-r04y1j22	483	33	for	for	IN
cord-023439-r04y1j22	483	34	the	the	DT
cord-023439-r04y1j22	483	35	development	development	NN
cord-023439-r04y1j22	483	36	of	of	IN
cord-023439-r04y1j22	483	37	SLE	SLE	NNP
cord-023439-r04y1j22	483	38	.	.	.
cord-023439-r04y1j22	484	1	This	this	DT
cord-023439-r04y1j22	484	2	is	be	VBZ
cord-023439-r04y1j22	484	3	supported	support	VBN
cord-023439-r04y1j22	484	4	by	by	IN
cord-023439-r04y1j22	484	5	the	the	DT
cord-023439-r04y1j22	484	6	fact	fact	NN
cord-023439-r04y1j22	484	7	that	that	IN
cord-023439-r04y1j22	484	8	the	the	DT
cord-023439-r04y1j22	484	9	absence	absence	NN
cord-023439-r04y1j22	484	10	of	of	IN
cord-023439-r04y1j22	484	11	C3	C3	NNP
cord-023439-r04y1j22	484	12	is	be	VBZ
cord-023439-r04y1j22	484	13	not	not	RB
cord-023439-r04y1j22	484	14	a	a	DT
cord-023439-r04y1j22	484	15	predisposing	predisposing	JJ
cord-023439-r04y1j22	484	16	factor	factor	NN
cord-023439-r04y1j22	484	17	for	for	IN
cord-023439-r04y1j22	484	18	SLE	SLE	NNP
cord-023439-r04y1j22	484	19	and	and	CC
cord-023439-r04y1j22	484	20	our	-PRON-	PRP$
cord-023439-r04y1j22	484	21	observation	observation	NN
cord-023439-r04y1j22	484	22	that	that	IN
cord-023439-r04y1j22	484	23	C3	c3	NN
cord-023439-r04y1j22	484	24	def	def	NN
cord-023439-r04y1j22	484	25	.	.	.
cord-023439-r04y1j22	485	1	animals	animal	NNS
cord-023439-r04y1j22	485	2	display	display	VBP
cord-023439-r04y1j22	485	3	low	low	JJ
cord-023439-r04y1j22	485	4	levels	level	NNS
cord-023439-r04y1j22	485	5	of	of	IN
cord-023439-r04y1j22	485	6	IFN	IFN	NNP
cord-023439-r04y1j22	485	7	-	-	:
cord-023439-r04y1j22	485	8	a	a	DT
cord-023439-r04y1j22	485	9	mRNA	mrna	NN
cord-023439-r04y1j22	485	10	.	.	.
cord-023439-r04y1j22	485	11	 	 	_SP
cord-023439-r04y1j22	486	1	200	200	CD
cord-023439-r04y1j22	486	2	-	-	SYM
cord-023439-r04y1j22	486	3	400	400	CD
cord-023439-r04y1j22	486	4	million	million	CD
cord-023439-r04y1j22	486	5	people	people	NNS
cord-023439-r04y1j22	486	6	worldwide	worldwide	RB
cord-023439-r04y1j22	486	7	and	and	CC
cord-023439-r04y1j22	486	8	represents	represent	VBZ
cord-023439-r04y1j22	486	9	one	one	CD
cord-023439-r04y1j22	486	10	of	of	IN
cord-023439-r04y1j22	486	11	the	the	DT
cord-023439-r04y1j22	486	12	leading	lead	VBG
cord-023439-r04y1j22	486	13	causes	cause	NNS
cord-023439-r04y1j22	486	14	for	for	IN
cord-023439-r04y1j22	486	15	liver	liver	NN
cord-023439-r04y1j22	486	16	cirrhosis	cirrhosis	NN
cord-023439-r04y1j22	486	17	and	and	CC
cord-023439-r04y1j22	486	18	hepatocellular	hepatocellular	JJ
cord-023439-r04y1j22	486	19	carcinoma	carcinoma	NN
cord-023439-r04y1j22	486	20	.	.	.
cord-023439-r04y1j22	487	1	Control	control	NN
cord-023439-r04y1j22	487	2	over	over	IN
cord-023439-r04y1j22	487	3	the	the	DT
cord-023439-r04y1j22	487	4	HBV	HBV	NNP
cord-023439-r04y1j22	487	5	infection	infection	NN
cord-023439-r04y1j22	487	6	is	be	VBZ
cord-023439-r04y1j22	487	7	achieved	achieve	VBN
cord-023439-r04y1j22	487	8	mainly	mainly	RB
cord-023439-r04y1j22	487	9	by	by	IN
cord-023439-r04y1j22	487	10	vaccination	vaccination	NN
cord-023439-r04y1j22	487	11	with	with	IN
cord-023439-r04y1j22	487	12	Hepatitis	Hepatitis	NNP
cord-023439-r04y1j22	487	13	B	B	NNP
cord-023439-r04y1j22	487	14	surface	surface	NN
cord-023439-r04y1j22	487	15	antigen	antigen	NN
cord-023439-r04y1j22	487	16	(	(	-LRB-
cord-023439-r04y1j22	487	17	HBsAg	hbsag	ADD
cord-023439-r04y1j22	487	18	)	)	-RRB-
cord-023439-r04y1j22	487	19	.	.	.
cord-023439-r04y1j22	488	1	HBsAg	HBsAg	NNP
cord-023439-r04y1j22	488	2	contains	contain	VBZ
cord-023439-r04y1j22	488	3	N	n	CD
cord-023439-r04y1j22	488	4	-	-	HYPH
cord-023439-r04y1j22	488	5	linked	link	VBN
cord-023439-r04y1j22	488	6	glycosylation	glycosylation	NN
cord-023439-r04y1j22	488	7	side	side	NN
cord-023439-r04y1j22	488	8	and	and	CC
cord-023439-r04y1j22	488	9	is	be	VBZ
cord-023439-r04y1j22	488	10	recognized	recognize	VBN
cord-023439-r04y1j22	488	11	by	by	IN
cord-023439-r04y1j22	488	12	both	both	DT
cord-023439-r04y1j22	488	13	MBL	MBL	NNP
cord-023439-r04y1j22	488	14	-	-	HYPH
cord-023439-r04y1j22	488	15	A	A	NNP
cord-023439-r04y1j22	488	16	and	and	CC
cord-023439-r04y1j22	488	17	MBL	MBL	NNP
cord-023439-r04y1j22	488	18	-	-	HYPH
cord-023439-r04y1j22	488	19	C	C	NNP
cord-023439-r04y1j22	488	20	in	in	IN
cord-023439-r04y1j22	488	21	a	a	DT
cord-023439-r04y1j22	488	22	Cadependent	Cadependent	NNP
cord-023439-r04y1j22	488	23	manner	manner	NN
cord-023439-r04y1j22	488	24	.	.	.
cord-023439-r04y1j22	489	1	HbsAg	HbsAg	NNP
cord-023439-r04y1j22	489	2	-	-	HYPH
cord-023439-r04y1j22	489	3	MBL	MBL	NNP
cord-023439-r04y1j22	489	4	complexes	complex	NNS
cord-023439-r04y1j22	489	5	activate	activate	VBP
cord-023439-r04y1j22	489	6	complement	complement	NN
cord-023439-r04y1j22	489	7	and	and	CC
cord-023439-r04y1j22	489	8	may	may	MD
cord-023439-r04y1j22	489	9	thus	thus	RB
cord-023439-r04y1j22	489	10	affect	affect	VB
cord-023439-r04y1j22	489	11	humoural	humoural	JJ
cord-023439-r04y1j22	489	12	immunity	immunity	NN
cord-023439-r04y1j22	489	13	.	.	.
cord-023439-r04y1j22	490	1	To	to	TO
cord-023439-r04y1j22	490	2	investigate	investigate	VB
cord-023439-r04y1j22	490	3	the	the	DT
cord-023439-r04y1j22	490	4	role	role	NN
cord-023439-r04y1j22	490	5	of	of	IN
cord-023439-r04y1j22	490	6	MBL	MBL	NNP
cord-023439-r04y1j22	490	7	in	in	IN
cord-023439-r04y1j22	490	8	humoural	humoural	NNP
cord-023439-r04y1j22	490	9	responses	response	NNS
cord-023439-r04y1j22	490	10	to	to	IN
cord-023439-r04y1j22	490	11	HBsAg	hbsag	ADD
cord-023439-r04y1j22	490	12	,	,	,
cord-023439-r04y1j22	490	13	we	-PRON-	PRP
cord-023439-r04y1j22	490	14	immununized	immununize	VBD
cord-023439-r04y1j22	490	15	mice	mouse	NNS
cord-023439-r04y1j22	490	16	that	that	WDT
cord-023439-r04y1j22	490	17	lack	lack	VBP
cord-023439-r04y1j22	490	18	both	both	DT
cord-023439-r04y1j22	490	19	MBL	MBL	NNP
cord-023439-r04y1j22	490	20	-	-	HYPH
cord-023439-r04y1j22	490	21	A	A	NNP
cord-023439-r04y1j22	490	22	and	and	CC
cord-023439-r04y1j22	490	23	MBL	MBL	NNP
cord-023439-r04y1j22	490	24	-	-	HYPH
cord-023439-r04y1j22	490	25	C	c	NN
cord-023439-r04y1j22	490	26	proteins	protein	NNS
cord-023439-r04y1j22	490	27	with	with	IN
cord-023439-r04y1j22	490	28	soluble	soluble	JJ
cord-023439-r04y1j22	490	29	HBsAg	hbsag	ADD
cord-023439-r04y1j22	490	30	.	.	.
cord-023439-r04y1j22	491	1	It	-PRON-	PRP
cord-023439-r04y1j22	491	2	has	have	VBZ
cord-023439-r04y1j22	491	3	been	be	VBN
cord-023439-r04y1j22	491	4	shown	show	VBN
cord-023439-r04y1j22	491	5	that	that	IN
cord-023439-r04y1j22	491	6	deficiencies	deficiency	NNS
cord-023439-r04y1j22	491	7	in	in	IN
cord-023439-r04y1j22	491	8	other	other	JJ
cord-023439-r04y1j22	491	9	complement	complement	NN
cord-023439-r04y1j22	491	10	components	component	NNS
cord-023439-r04y1j22	491	11	like	like	IN
cord-023439-r04y1j22	491	12	C1q	C1q	NNP
cord-023439-r04y1j22	491	13	,	,	,
cord-023439-r04y1j22	491	14	C4	C4	NNP
cord-023439-r04y1j22	491	15	and	and	CC
cord-023439-r04y1j22	491	16	C3	c3	NN
cord-023439-r04y1j22	491	17	result	result	NN
cord-023439-r04y1j22	491	18	in	in	IN
cord-023439-r04y1j22	491	19	decreased	decrease	VBN
cord-023439-r04y1j22	491	20	antibody	antibody	NN
cord-023439-r04y1j22	491	21	responses	response	NNS
cord-023439-r04y1j22	491	22	.	.	.
cord-023439-r04y1j22	492	1	However	however	RB
cord-023439-r04y1j22	492	2	,	,	,
cord-023439-r04y1j22	492	3	MBL	MBL	NNP
cord-023439-r04y1j22	492	4	double	double	JJ
cord-023439-r04y1j22	492	5	KO	KO	NNP
cord-023439-r04y1j22	492	6	animals	animal	NNS
cord-023439-r04y1j22	492	7	mounted	mount	VBD
cord-023439-r04y1j22	492	8	dramatically	dramatically	RB
cord-023439-r04y1j22	492	9	increased	increase	VBN
cord-023439-r04y1j22	492	10	humoural	humoural	JJ
cord-023439-r04y1j22	492	11	responses	response	NNS
cord-023439-r04y1j22	492	12	.	.	.
cord-023439-r04y1j22	493	1	After	after	IN
cord-023439-r04y1j22	493	2	priming	prime	VBG
cord-023439-r04y1j22	493	3	,	,	,
cord-023439-r04y1j22	493	4	MBL	MBL	NNP
cord-023439-r04y1j22	493	5	double	double	JJ
cord-023439-r04y1j22	493	6	KOs	KOs	NNP
cord-023439-r04y1j22	493	7	mounted	mount	VBD
cord-023439-r04y1j22	493	8	HbsAg	HbsAg	NNP
cord-023439-r04y1j22	493	9	-	-	HYPH
cord-023439-r04y1j22	493	10	specific	specific	JJ
cord-023439-r04y1j22	493	11	IgM	IgM	NNP
cord-023439-r04y1j22	493	12	responses	response	NNS
cord-023439-r04y1j22	493	13	,	,	,
cord-023439-r04y1j22	493	14	which	which	WDT
cord-023439-r04y1j22	493	15	were	be	VBD
cord-023439-r04y1j22	493	16	threefold	threefold	RB
cord-023439-r04y1j22	493	17	higher	high	JJR
cord-023439-r04y1j22	493	18	than	than	IN
cord-023439-r04y1j22	493	19	WT	WT	NNP
cord-023439-r04y1j22	493	20	controls	control	NNS
cord-023439-r04y1j22	493	21	.	.	.
cord-023439-r04y1j22	494	1	After	after	IN
cord-023439-r04y1j22	494	2	boosting	boost	VBG
cord-023439-r04y1j22	494	3	the	the	DT
cord-023439-r04y1j22	494	4	HBsAg	hbsag	XX
cord-023439-r04y1j22	494	5	,	,	,
cord-023439-r04y1j22	494	6	total	total	JJ
cord-023439-r04y1j22	494	7	IgG	igg	NN
cord-023439-r04y1j22	494	8	was	be	VBD
cord-023439-r04y1j22	494	9	10-fold	10-fold	JJ
cord-023439-r04y1j22	494	10	higher	high	JJR
cord-023439-r04y1j22	494	11	in	in	IN
cord-023439-r04y1j22	494	12	MBL	MBL	NNP
cord-023439-r04y1j22	494	13	KO	KO	NNP
cord-023439-r04y1j22	494	14	than	than	IN
cord-023439-r04y1j22	494	15	in	in	IN
cord-023439-r04y1j22	494	16	WT	WT	NNP
cord-023439-r04y1j22	494	17	control	control	NN
cord-023439-r04y1j22	494	18	animals	animal	NNS
cord-023439-r04y1j22	494	19	.	.	.
cord-023439-r04y1j22	495	1	Similar	similar	JJ
cord-023439-r04y1j22	495	2	to	to	IN
cord-023439-r04y1j22	495	3	the	the	DT
cord-023439-r04y1j22	495	4	response	response	NN
cord-023439-r04y1j22	495	5	to	to	TO
cord-023439-r04y1j22	495	6	HbsAg	HbsAg	NNP
cord-023439-r04y1j22	495	7	,	,	,
cord-023439-r04y1j22	495	8	other	other	JJ
cord-023439-r04y1j22	495	9	glycosylated	glycosylated	JJ
cord-023439-r04y1j22	495	10	soluble	soluble	JJ
cord-023439-r04y1j22	495	11	antigens	antigen	NNS
cord-023439-r04y1j22	495	12	(	(	-LRB-
cord-023439-r04y1j22	495	13	e.g.	e.g.	IN
cord-023439-r04y1j22	495	14	invertase	invertase	NNP
cord-023439-r04y1j22	495	15	)	)	-RRB-
cord-023439-r04y1j22	495	16	induced	induce	VBN
cord-023439-r04y1j22	495	17	better	well	JJR
cord-023439-r04y1j22	495	18	humoural	humoural	JJ
cord-023439-r04y1j22	495	19	responses	response	NNS
cord-023439-r04y1j22	495	20	in	in	IN
cord-023439-r04y1j22	495	21	MBL	MBL	NNP
cord-023439-r04y1j22	495	22	double	double	JJ
cord-023439-r04y1j22	495	23	KO	KO	NNP
cord-023439-r04y1j22	495	24	animals	animal	NNS
cord-023439-r04y1j22	495	25	,	,	,
cord-023439-r04y1j22	495	26	suggesting	suggest	VBG
cord-023439-r04y1j22	495	27	that	that	IN
cord-023439-r04y1j22	495	28	MBL	MBL	NNP
cord-023439-r04y1j22	495	29	plays	play	VBZ
cord-023439-r04y1j22	495	30	an	an	DT
cord-023439-r04y1j22	495	31	important	important	JJ
cord-023439-r04y1j22	495	32	role	role	NN
cord-023439-r04y1j22	495	33	in	in	IN
cord-023439-r04y1j22	495	34	a	a	DT
cord-023439-r04y1j22	495	35	negative	negative	JJ
cord-023439-r04y1j22	495	36	feedback	feedback	NN
cord-023439-r04y1j22	495	37	regulation	regulation	NN
cord-023439-r04y1j22	495	38	of	of	IN
cord-023439-r04y1j22	495	39	adaptive	adaptive	JJ
cord-023439-r04y1j22	495	40	immunity	immunity	NN
cord-023439-r04y1j22	495	41	.	.	.
cord-023439-r04y1j22	496	1	Reconstitution	reconstitution	NN
cord-023439-r04y1j22	496	2	experiments	experiment	NNS
cord-023439-r04y1j22	496	3	with	with	IN
cord-023439-r04y1j22	496	4	rMBL	rMBL	NNS
cord-023439-r04y1j22	496	5	partially	partially	RB
cord-023439-r04y1j22	496	6	rescued	rescue	VBD
cord-023439-r04y1j22	496	7	the	the	DT
cord-023439-r04y1j22	496	8	KO	KO	NNP
cord-023439-r04y1j22	496	9	phenotype	phenotype	NN
cord-023439-r04y1j22	496	10	.	.	.
cord-023439-r04y1j22	497	1	We	-PRON-	PRP
cord-023439-r04y1j22	497	2	propose	propose	VBP
cord-023439-r04y1j22	497	3	that	that	IN
cord-023439-r04y1j22	497	4	the	the	DT
cord-023439-r04y1j22	497	5	clearance	clearance	NN
cord-023439-r04y1j22	497	6	of	of	IN
cord-023439-r04y1j22	497	7	glycoprotein	glycoprotein	NN
cord-023439-r04y1j22	497	8	antigens	antigen	NNS
cord-023439-r04y1j22	497	9	in	in	IN
cord-023439-r04y1j22	497	10	MBL	MBL	NNP
cord-023439-r04y1j22	497	11	KO	KO	NNP
cord-023439-r04y1j22	497	12	is	be	VBZ
cord-023439-r04y1j22	497	13	handled	handle	VBN
cord-023439-r04y1j22	497	14	differently	differently	RB
cord-023439-r04y1j22	497	15	from	from	IN
cord-023439-r04y1j22	497	16	the	the	DT
cord-023439-r04y1j22	497	17	WT	WT	NNP
cord-023439-r04y1j22	497	18	,	,	,
cord-023439-r04y1j22	497	19	resulting	result	VBG
cord-023439-r04y1j22	497	20	in	in	IN
cord-023439-r04y1j22	497	21	better	well	JJR
cord-023439-r04y1j22	497	22	stimulation	stimulation	NN
cord-023439-r04y1j22	497	23	of	of	IN
cord-023439-r04y1j22	497	24	humoural	humoural	JJ
cord-023439-r04y1j22	497	25	responses	response	NNS
cord-023439-r04y1j22	497	26	.	.	.
cord-023439-r04y1j22	498	1	Alternatively	alternatively	RB
cord-023439-r04y1j22	498	2	,	,	,
cord-023439-r04y1j22	498	3	glycoprotein	glycoprotein	NN
cord-023439-r04y1j22	498	4	-	-	:
cord-023439-r04y1j22	498	5	Ag	Ag	NNP
cord-023439-r04y1j22	498	6	-	-	HYPH
cord-023439-r04y1j22	498	7	MBL	MBL	NNP
cord-023439-r04y1j22	498	8	-	-	HYPH
cord-023439-r04y1j22	498	9	rich	rich	JJ
cord-023439-r04y1j22	498	10	complexes	complex	NNS
cord-023439-r04y1j22	498	11	inhibit	inhibit	VBP
cord-023439-r04y1j22	498	12	B	b	NN
cord-023439-r04y1j22	498	13	-	-	HYPH
cord-023439-r04y1j22	498	14	cell	cell	NN
cord-023439-r04y1j22	498	15	responsiveness	responsiveness	NN
cord-023439-r04y1j22	498	16	via	via	IN
cord-023439-r04y1j22	498	17	putative	putative	JJ
cord-023439-r04y1j22	498	18	MBL	MBL	NNP
cord-023439-r04y1j22	498	19	receptors	receptor	NNS
cord-023439-r04y1j22	498	20	.	.	.
cord-023439-r04y1j22	499	1	The	the	DT
cord-023439-r04y1j22	499	2	complement	complement	NN
cord-023439-r04y1j22	499	3	system	system	NN
cord-023439-r04y1j22	499	4	is	be	VBZ
cord-023439-r04y1j22	499	5	an	an	DT
cord-023439-r04y1j22	499	6	important	important	JJ
cord-023439-r04y1j22	499	7	part	part	NN
cord-023439-r04y1j22	499	8	of	of	IN
cord-023439-r04y1j22	499	9	the	the	DT
cord-023439-r04y1j22	499	10	innate	innate	JJ
cord-023439-r04y1j22	499	11	immune	immune	JJ
cord-023439-r04y1j22	499	12	system	system	NN
cord-023439-r04y1j22	499	13	.	.	.
cord-023439-r04y1j22	500	1	The	the	DT
cord-023439-r04y1j22	500	2	activation	activation	NN
cord-023439-r04y1j22	500	3	of	of	IN
cord-023439-r04y1j22	500	4	complement	complement	NN
cord-023439-r04y1j22	500	5	proceeds	proceed	VBZ
cord-023439-r04y1j22	500	6	through	through	IN
cord-023439-r04y1j22	500	7	three	three	CD
cord-023439-r04y1j22	500	8	different	different	JJ
cord-023439-r04y1j22	500	9	pathways	pathway	NNS
cord-023439-r04y1j22	500	10	that	that	WDT
cord-023439-r04y1j22	500	11	converge	converge	VBP
cord-023439-r04y1j22	500	12	in	in	IN
cord-023439-r04y1j22	500	13	the	the	DT
cord-023439-r04y1j22	500	14	generation	generation	NN
cord-023439-r04y1j22	500	15	of	of	IN
cord-023439-r04y1j22	500	16	C3-activating	c3-activate	VBG
cord-023439-r04y1j22	500	17	enzyme	enzyme	NN
cord-023439-r04y1j22	500	18	complexes	complex	NNS
cord-023439-r04y1j22	500	19	.	.	.
cord-023439-r04y1j22	501	1	Complement	complement	JJ
cord-023439-r04y1j22	501	2	activation	activation	NN
cord-023439-r04y1j22	501	3	via	via	IN
cord-023439-r04y1j22	501	4	the	the	DT
cord-023439-r04y1j22	501	5	lectin	lectin	NN
cord-023439-r04y1j22	501	6	pathway	pathway	NN
cord-023439-r04y1j22	501	7	is	be	VBZ
cord-023439-r04y1j22	501	8	initiated	initiate	VBN
cord-023439-r04y1j22	501	9	when	when	WRB
cord-023439-r04y1j22	501	10	recognition	recognition	NN
cord-023439-r04y1j22	501	11	molecules	molecule	NNS
cord-023439-r04y1j22	501	12	,	,	,
cord-023439-r04y1j22	501	13	mannan	mannan	NN
cord-023439-r04y1j22	501	14	-	-	HYPH
cord-023439-r04y1j22	501	15	binding	bind	VBG
cord-023439-r04y1j22	501	16	lectin	lectin	NN
cord-023439-r04y1j22	501	17	(	(	-LRB-
cord-023439-r04y1j22	501	18	MBL	MBL	NNP
cord-023439-r04y1j22	501	19	)	)	-RRB-
cord-023439-r04y1j22	501	20	or	or	CC
cord-023439-r04y1j22	501	21	ficolin	ficolin	NN
cord-023439-r04y1j22	501	22	,	,	,
cord-023439-r04y1j22	501	23	bind	bind	VB
cord-023439-r04y1j22	501	24	to	to	IN
cord-023439-r04y1j22	501	25	carbohydrate	carbohydrate	NN
cord-023439-r04y1j22	501	26	structures	structure	NNS
cord-023439-r04y1j22	501	27	characteristic	characteristic	JJ
cord-023439-r04y1j22	501	28	for	for	IN
cord-023439-r04y1j22	501	29	microbial	microbial	JJ
cord-023439-r04y1j22	501	30	surfaces	surface	NNS
cord-023439-r04y1j22	501	31	.	.	.
cord-023439-r04y1j22	502	1	In	in	IN
cord-023439-r04y1j22	502	2	the	the	DT
cord-023439-r04y1j22	502	3	circulation	circulation	NN
cord-023439-r04y1j22	502	4	,	,	,
cord-023439-r04y1j22	502	5	MBL	MBL	NNP
cord-023439-r04y1j22	502	6	and	and	CC
cord-023439-r04y1j22	502	7	ficolins	ficolin	NNS
cord-023439-r04y1j22	502	8	are	be	VBP
cord-023439-r04y1j22	502	9	found	find	VBN
cord-023439-r04y1j22	502	10	in	in	IN
cord-023439-r04y1j22	502	11	association	association	NN
cord-023439-r04y1j22	502	12	with	with	IN
cord-023439-r04y1j22	502	13	three	three	CD
cord-023439-r04y1j22	502	14	structurally	structurally	RB
cord-023439-r04y1j22	502	15	related	relate	VBN
cord-023439-r04y1j22	502	16	MBLassociated	mblassociated	JJ
cord-023439-r04y1j22	502	17	serine	serine	NN
cord-023439-r04y1j22	502	18	proteases	protease	NNS
cord-023439-r04y1j22	502	19	(	(	-LRB-
cord-023439-r04y1j22	502	20	MASP)-1	masp)-1	NN
cord-023439-r04y1j22	502	21	,	,	,
cord-023439-r04y1j22	502	22	-2	-2	NNP
cord-023439-r04y1j22	502	23	and	and	CC
cord-023439-r04y1j22	502	24	-3	-3	NNP
cord-023439-r04y1j22	502	25	and	and	CC
cord-023439-r04y1j22	502	26	a	a	DT
cord-023439-r04y1j22	502	27	small	small	JJ
cord-023439-r04y1j22	502	28	,	,	,
cord-023439-r04y1j22	502	29	nonenzymatic	nonenzymatic	JJ
cord-023439-r04y1j22	502	30	component	component	NN
cord-023439-r04y1j22	502	31	,	,	,
cord-023439-r04y1j22	502	32	MAp19	MAp19	NNP
cord-023439-r04y1j22	502	33	.	.	.
cord-023439-r04y1j22	503	1	MASP-2	MASP-2	NNP
cord-023439-r04y1j22	503	2	has	have	VBZ
cord-023439-r04y1j22	503	3	been	be	VBN
cord-023439-r04y1j22	503	4	shown	show	VBN
cord-023439-r04y1j22	503	5	to	to	TO
cord-023439-r04y1j22	503	6	elicit	elicit	VB
cord-023439-r04y1j22	503	7	complement	complement	NN
cord-023439-r04y1j22	503	8	activation	activation	NN
cord-023439-r04y1j22	503	9	through	through	IN
cord-023439-r04y1j22	503	10	the	the	DT
cord-023439-r04y1j22	503	11	sequential	sequential	JJ
cord-023439-r04y1j22	503	12	proteolytic	proteolytic	JJ
cord-023439-r04y1j22	503	13	cleavage	cleavage	NN
cord-023439-r04y1j22	503	14	of	of	IN
cord-023439-r04y1j22	503	15	C4	c4	NN
cord-023439-r04y1j22	503	16	and	and	CC
cord-023439-r04y1j22	503	17	C2	C2	NNP
cord-023439-r04y1j22	503	18	upon	upon	IN
cord-023439-r04y1j22	503	19	binding	bind	VBG
cord-023439-r04y1j22	503	20	of	of	IN
cord-023439-r04y1j22	503	21	MBL	MBL	NNP
cord-023439-r04y1j22	503	22	/	/	SYM
cord-023439-r04y1j22	503	23	MASP-2	masp-2	NN
cord-023439-r04y1j22	503	24	complexes	complex	NNS
cord-023439-r04y1j22	503	25	to	to	IN
cord-023439-r04y1j22	503	26	microbial	microbial	JJ
cord-023439-r04y1j22	503	27	surfaces	surface	NNS
cord-023439-r04y1j22	503	28	.	.	.
cord-023439-r04y1j22	504	1	We	-PRON-	PRP
cord-023439-r04y1j22	504	2	have	have	VBP
cord-023439-r04y1j22	504	3	recently	recently	RB
cord-023439-r04y1j22	504	4	uncovered	uncover	VBN
cord-023439-r04y1j22	504	5	a	a	DT
cord-023439-r04y1j22	504	6	polymorphism	polymorphism	NN
cord-023439-r04y1j22	504	7	in	in	IN
cord-023439-r04y1j22	504	8	the	the	DT
cord-023439-r04y1j22	504	9	MASP-2	MASP-2	NNP
cord-023439-r04y1j22	504	10	/	/	SYM
cord-023439-r04y1j22	504	11	MAp19	map19	NN
cord-023439-r04y1j22	504	12	gene	gene	NN
cord-023439-r04y1j22	504	13	in	in	IN
cord-023439-r04y1j22	504	14	a	a	DT
cord-023439-r04y1j22	504	15	patient	patient	NN
cord-023439-r04y1j22	504	16	shown	show	VBN
cord-023439-r04y1j22	504	17	to	to	TO
cord-023439-r04y1j22	504	18	be	be	VB
cord-023439-r04y1j22	504	19	deficient	deficient	JJ
cord-023439-r04y1j22	504	20	in	in	IN
cord-023439-r04y1j22	504	21	the	the	DT
cord-023439-r04y1j22	504	22	lectin	lectin	NN
cord-023439-r04y1j22	504	23	pathway	pathway	NN
cord-023439-r04y1j22	504	24	of	of	IN
cord-023439-r04y1j22	504	25	complement	complement	JJ
cord-023439-r04y1j22	504	26	activation	activation	NN
cord-023439-r04y1j22	504	27	.	.	.
cord-023439-r04y1j22	505	1	The	the	DT
cord-023439-r04y1j22	505	2	polymorphism	polymorphism	NN
cord-023439-r04y1j22	505	3	results	result	VBZ
cord-023439-r04y1j22	505	4	in	in	IN
cord-023439-r04y1j22	505	5	a	a	DT
cord-023439-r04y1j22	505	6	single	single	JJ
cord-023439-r04y1j22	505	7	amino	amino	NN
cord-023439-r04y1j22	505	8	acid	acid	NN
cord-023439-r04y1j22	505	9	substitution	substitution	NN
cord-023439-r04y1j22	505	10	in	in	IN
cord-023439-r04y1j22	505	11	the	the	DT
cord-023439-r04y1j22	505	12	N	n	CD
cord-023439-r04y1j22	505	13	-	-	HYPH
cord-023439-r04y1j22	505	14	terminal	terminal	JJ
cord-023439-r04y1j22	505	15	part	part	NN
cord-023439-r04y1j22	505	16	of	of	IN
cord-023439-r04y1j22	505	17	the	the	DT
cord-023439-r04y1j22	505	18	MASP-2	MASP-2	NNP
cord-023439-r04y1j22	505	19	protein	protein	NN
cord-023439-r04y1j22	505	20	.	.	.
cord-023439-r04y1j22	506	1	Recombinant	recombinant	JJ
cord-023439-r04y1j22	506	2	wildtype	wildtype	NN
cord-023439-r04y1j22	506	3	MASP-2	MASP-2	NNP
cord-023439-r04y1j22	506	4	and	and	CC
cord-023439-r04y1j22	506	5	MASP-2	MASP-2	NNP
cord-023439-r04y1j22	506	6	containing	contain	VBG
cord-023439-r04y1j22	506	7	the	the	DT
cord-023439-r04y1j22	506	8	amino	amino	NN
cord-023439-r04y1j22	506	9	acid	acid	NN
cord-023439-r04y1j22	506	10	substitution	substitution	NN
cord-023439-r04y1j22	506	11	in	in	IN
cord-023439-r04y1j22	506	12	question	question	NN
cord-023439-r04y1j22	506	13	was	be	VBD
cord-023439-r04y1j22	506	14	produced	produce	VBN
cord-023439-r04y1j22	506	15	,	,	,
cord-023439-r04y1j22	506	16	and	and	CC
cord-023439-r04y1j22	506	17	the	the	DT
cord-023439-r04y1j22	506	18	ability	ability	NN
cord-023439-r04y1j22	506	19	to	to	TO
cord-023439-r04y1j22	506	20	activate	activate	VB
cord-023439-r04y1j22	506	21	complement	complement	NN
cord-023439-r04y1j22	506	22	was	be	VBD
cord-023439-r04y1j22	506	23	studied	study	VBN
cord-023439-r04y1j22	506	24	.	.	.
cord-023439-r04y1j22	507	1	The	the	DT
cord-023439-r04y1j22	507	2	mutation	mutation	NN
cord-023439-r04y1j22	507	3	had	have	VBD
cord-023439-r04y1j22	507	4	a	a	DT
cord-023439-r04y1j22	507	5	profound	profound	JJ
cord-023439-r04y1j22	507	6	impact	impact	NN
cord-023439-r04y1j22	507	7	on	on	IN
cord-023439-r04y1j22	507	8	MASP-2	masp-2	NN
cord-023439-r04y1j22	507	9	function	function	NN
cord-023439-r04y1j22	507	10	,	,	,
cord-023439-r04y1j22	507	11	resulting	result	VBG
cord-023439-r04y1j22	507	12	in	in	IN
cord-023439-r04y1j22	507	13	the	the	DT
cord-023439-r04y1j22	507	14	lack	lack	NN
cord-023439-r04y1j22	507	15	of	of	IN
cord-023439-r04y1j22	507	16	complement	complement	JJ
cord-023439-r04y1j22	507	17	activation	activation	NN
cord-023439-r04y1j22	507	18	through	through	IN
cord-023439-r04y1j22	507	19	the	the	DT
cord-023439-r04y1j22	507	20	lectin	lectin	NN
cord-023439-r04y1j22	507	21	pathway	pathway	NN
cord-023439-r04y1j22	507	22	.	.	.
cord-023439-r04y1j22	508	1	ELISA	ELISA	NNP
cord-023439-r04y1j22	508	2	-	-	HYPH
cord-023439-r04y1j22	508	3	based	base	VBN
cord-023439-r04y1j22	508	4	experiments	experiment	NNS
cord-023439-r04y1j22	508	5	showed	show	VBD
cord-023439-r04y1j22	508	6	that	that	IN
cord-023439-r04y1j22	508	7	the	the	DT
cord-023439-r04y1j22	508	8	mutation	mutation	NN
cord-023439-r04y1j22	508	9	leads	lead	VBZ
cord-023439-r04y1j22	508	10	to	to	IN
cord-023439-r04y1j22	508	11	the	the	DT
cord-023439-r04y1j22	508	12	impairment	impairment	NN
cord-023439-r04y1j22	508	13	of	of	IN
cord-023439-r04y1j22	508	14	complement	complement	JJ
cord-023439-r04y1j22	508	15	activation	activation	NN
cord-023439-r04y1j22	508	16	through	through	IN
cord-023439-r04y1j22	508	17	influencing	influence	VBG
cord-023439-r04y1j22	508	18	the	the	DT
cord-023439-r04y1j22	508	19	binding	binding	NN
cord-023439-r04y1j22	508	20	of	of	IN
cord-023439-r04y1j22	508	21	MASP-2	MASP-2	NNP
cord-023439-r04y1j22	508	22	to	to	IN
cord-023439-r04y1j22	508	23	MBL	MBL	NNP
cord-023439-r04y1j22	508	24	or	or	CC
cord-023439-r04y1j22	508	25	ficolins	ficolin	NNS
cord-023439-r04y1j22	508	26	.	.	.
cord-023439-r04y1j22	509	1	Deficiencies	deficiency	NNS
cord-023439-r04y1j22	509	2	in	in	IN
cord-023439-r04y1j22	509	3	the	the	DT
cord-023439-r04y1j22	509	4	lectin	lectin	NN
cord-023439-r04y1j22	509	5	pathway	pathway	NN
cord-023439-r04y1j22	509	6	of	of	IN
cord-023439-r04y1j22	509	7	complement	complement	JJ
cord-023439-r04y1j22	509	8	activation	activation	NN
cord-023439-r04y1j22	509	9	have	have	VBP
cord-023439-r04y1j22	509	10	so	so	RB
cord-023439-r04y1j22	509	11	far	far	RB
cord-023439-r04y1j22	509	12	been	be	VBN
cord-023439-r04y1j22	509	13	accounted	account	VBN
cord-023439-r04y1j22	509	14	for	for	IN
cord-023439-r04y1j22	509	15	only	only	RB
cord-023439-r04y1j22	509	16	by	by	IN
cord-023439-r04y1j22	509	17	lack	lack	NN
cord-023439-r04y1j22	509	18	of	of	IN
cord-023439-r04y1j22	509	19	functional	functional	JJ
cord-023439-r04y1j22	509	20	MBL	MBL	NNS
cord-023439-r04y1j22	509	21	.	.	.
cord-023439-r04y1j22	510	1	The	the	DT
cord-023439-r04y1j22	510	2	mutation	mutation	NN
cord-023439-r04y1j22	510	3	described	describe	VBN
cord-023439-r04y1j22	510	4	above	above	RB
cord-023439-r04y1j22	510	5	is	be	VBZ
cord-023439-r04y1j22	510	6	the	the	DT
cord-023439-r04y1j22	510	7	first	first	JJ
cord-023439-r04y1j22	510	8	defect	defect	NN
cord-023439-r04y1j22	510	9	described	describe	VBN
cord-023439-r04y1j22	510	10	affecting	affect	VBG
cord-023439-r04y1j22	510	11	both	both	DT
cord-023439-r04y1j22	510	12	activation	activation	NN
cord-023439-r04y1j22	510	13	through	through	IN
cord-023439-r04y1j22	510	14	MBL	MBL	NNP
cord-023439-r04y1j22	510	15	and	and	CC
cord-023439-r04y1j22	510	16	the	the	DT
cord-023439-r04y1j22	510	17	ficolins	ficolin	NNS
cord-023439-r04y1j22	510	18	.	.	.
cord-023439-r04y1j22	510	19	..................................................................................................................................................................................................	..................................................................................................................................................................................................	.
cord-023439-r04y1j22	511	1	Th1	Th1	NNP
cord-023439-r04y1j22	511	2	,	,	,
cord-023439-r04y1j22	511	3	Th2	Th2	NNP
cord-023439-r04y1j22	511	4	and	and	CC
cord-023439-r04y1j22	511	5	Treg	Treg	NNP
cord-023439-r04y1j22	511	6	cell	cell	NN
cord-023439-r04y1j22	511	7	balance	balance	NN
cord-023439-r04y1j22	511	8	.	.	.
cord-023439-r04y1j22	512	1	DCs	DCs	NNP
cord-023439-r04y1j22	512	2	are	be	VBP
cord-023439-r04y1j22	512	3	present	present	JJ
cord-023439-r04y1j22	512	4	in	in	IN
cord-023439-r04y1j22	512	5	the	the	DT
cord-023439-r04y1j22	512	6	gut	gut	NN
cord-023439-r04y1j22	512	7	mucosa	mucosa	NN
cord-023439-r04y1j22	512	8	and	and	CC
cord-023439-r04y1j22	512	9	may	may	MD
cord-023439-r04y1j22	512	10	thus	thus	RB
cord-023439-r04y1j22	512	11	be	be	VB
cord-023439-r04y1j22	512	12	target	target	NN
cord-023439-r04y1j22	512	13	for	for	IN
cord-023439-r04y1j22	512	14	modulation	modulation	NN
cord-023439-r04y1j22	512	15	by	by	IN
cord-023439-r04y1j22	512	16	gut	gut	NN
cord-023439-r04y1j22	512	17	microbes	microbe	NNS
cord-023439-r04y1j22	512	18	,	,	,
cord-023439-r04y1j22	512	19	including	include	VBG
cord-023439-r04y1j22	512	20	ingested	ingest	VBN
cord-023439-r04y1j22	512	21	probiotics	probiotic	NNS
cord-023439-r04y1j22	512	22	.	.	.
cord-023439-r04y1j22	513	1	Here	here	RB
cord-023439-r04y1j22	513	2	,	,	,
cord-023439-r04y1j22	513	3	we	-PRON-	PRP
cord-023439-r04y1j22	513	4	tested	test	VBD
cord-023439-r04y1j22	513	5	the	the	DT
cord-023439-r04y1j22	513	6	hypothesis	hypothesis	NN
cord-023439-r04y1j22	513	7	that	that	WDT
cord-023439-r04y1j22	513	8	species	specie	NNS
cord-023439-r04y1j22	513	9	of	of	IN
cord-023439-r04y1j22	513	10	lactic	lactic	JJ
cord-023439-r04y1j22	513	11	acid	acid	NN
cord-023439-r04y1j22	513	12	bacteria	bacteria	NNS
cord-023439-r04y1j22	513	13	,	,	,
cord-023439-r04y1j22	513	14	important	important	JJ
cord-023439-r04y1j22	513	15	members	member	NNS
cord-023439-r04y1j22	513	16	of	of	IN
cord-023439-r04y1j22	513	17	the	the	DT
cord-023439-r04y1j22	513	18	gut	gut	NN
cord-023439-r04y1j22	513	19	flora	flora	NNS
cord-023439-r04y1j22	513	20	,	,	,
cord-023439-r04y1j22	513	21	differentially	differentially	RB
cord-023439-r04y1j22	513	22	activate	activate	VB
cord-023439-r04y1j22	513	23	DC	DC	NNP
cord-023439-r04y1j22	513	24	.	.	.
cord-023439-r04y1j22	514	1	A	a	DT
cord-023439-r04y1j22	514	2	large	large	JJ
cord-023439-r04y1j22	514	3	panel	panel	NN
cord-023439-r04y1j22	514	4	of	of	IN
cord-023439-r04y1j22	514	5	human	human	JJ
cord-023439-r04y1j22	514	6	gut	gut	NN
cord-023439-r04y1j22	514	7	-	-	HYPH
cord-023439-r04y1j22	514	8	derived	derive	VBN
cord-023439-r04y1j22	514	9	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	514	10	and	and	CC
cord-023439-r04y1j22	514	11	Bifidobacterium	bifidobacterium	NN
cord-023439-r04y1j22	514	12	spp	spp	NNS
cord-023439-r04y1j22	514	13	.	.	.
cord-023439-r04y1j22	515	1	was	be	VBD
cord-023439-r04y1j22	515	2	screened	screen	VBN
cord-023439-r04y1j22	515	3	for	for	IN
cord-023439-r04y1j22	515	4	DC	DC	NNP
cord-023439-r04y1j22	515	5	-	-	HYPH
cord-023439-r04y1j22	515	6	polarizing	polarize	VBG
cord-023439-r04y1j22	515	7	capacity	capacity	NN
cord-023439-r04y1j22	515	8	by	by	IN
cord-023439-r04y1j22	515	9	exposing	expose	VBG
cord-023439-r04y1j22	515	10	bone	bone	NN
cord-023439-r04y1j22	515	11	marrow	marrow	NN
cord-023439-r04y1j22	515	12	-	-	HYPH
cord-023439-r04y1j22	515	13	derived	derive	VBN
cord-023439-r04y1j22	515	14	murine	murine	JJ
cord-023439-r04y1j22	515	15	DC	DC	NNP
cord-023439-r04y1j22	515	16	to	to	IN
cord-023439-r04y1j22	515	17	lethally	lethally	RB
cord-023439-r04y1j22	515	18	irradiated	irradiate	VBN
cord-023439-r04y1j22	515	19	bacteria	bacteria	NNS
cord-023439-r04y1j22	515	20	.	.	.
cord-023439-r04y1j22	516	1	Cytokines	cytokine	NNS
cord-023439-r04y1j22	516	2	in	in	IN
cord-023439-r04y1j22	516	3	culture	culture	NN
cord-023439-r04y1j22	516	4	supernatants	supernatant	NNS
cord-023439-r04y1j22	516	5	and	and	CC
cord-023439-r04y1j22	516	6	DC	DC	NNP
cord-023439-r04y1j22	516	7	-	-	HYPH
cord-023439-r04y1j22	516	8	surface	surface	NN
cord-023439-r04y1j22	516	9	maturation	maturation	NN
cord-023439-r04y1j22	516	10	markers	marker	NNS
cord-023439-r04y1j22	516	11	were	be	VBD
cord-023439-r04y1j22	516	12	analysed	analyse	VBN
cord-023439-r04y1j22	516	13	.	.	.
cord-023439-r04y1j22	517	1	Substantial	substantial	JJ
cord-023439-r04y1j22	517	2	differences	difference	NNS
cord-023439-r04y1j22	517	3	were	be	VBD
cord-023439-r04y1j22	517	4	found	find	VBN
cord-023439-r04y1j22	517	5	among	among	IN
cord-023439-r04y1j22	517	6	strains	strain	NNS
cord-023439-r04y1j22	517	7	in	in	IN
cord-023439-r04y1j22	517	8	the	the	DT
cord-023439-r04y1j22	517	9	capacity	capacity	NN
cord-023439-r04y1j22	517	10	to	to	TO
cord-023439-r04y1j22	517	11	induce	induce	VB
cord-023439-r04y1j22	517	12	interleukin-12	interleukin-12	XX
cord-023439-r04y1j22	517	13	(	(	-LRB-
cord-023439-r04y1j22	517	14	IL-12	IL-12	NNP
cord-023439-r04y1j22	517	15	)	)	-RRB-
cord-023439-r04y1j22	517	16	and	and	CC
cord-023439-r04y1j22	517	17	tumour	tumour	NN
cord-023439-r04y1j22	517	18	necrosis	necrosis	NN
cord-023439-r04y1j22	517	19	factor	factor	NN
cord-023439-r04y1j22	517	20	(	(	-LRB-
cord-023439-r04y1j22	518	1	TNF)-a	TNF)-a	NNP
cord-023439-r04y1j22	518	2	,	,	,
cord-023439-r04y1j22	518	3	while	while	IN
cord-023439-r04y1j22	518	4	the	the	DT
cord-023439-r04y1j22	518	5	differences	difference	NNS
cord-023439-r04y1j22	518	6	for	for	IN
cord-023439-r04y1j22	518	7	IL-10	IL-10	NNP
cord-023439-r04y1j22	518	8	and	and	CC
cord-023439-r04y1j22	518	9	IL-6	IL-6	NNP
cord-023439-r04y1j22	518	10	were	be	VBD
cord-023439-r04y1j22	518	11	less	less	RBR
cord-023439-r04y1j22	518	12	pronounced	pronounced	JJ
cord-023439-r04y1j22	518	13	.	.	.
cord-023439-r04y1j22	519	1	Bifidobacteria	Bifidobacteria	NNP
cord-023439-r04y1j22	519	2	tended	tend	VBD
cord-023439-r04y1j22	519	3	to	to	TO
cord-023439-r04y1j22	519	4	be	be	VB
cord-023439-r04y1j22	519	5	weak	weak	JJ
cord-023439-r04y1j22	519	6	IL-12	IL-12	NNP
cord-023439-r04y1j22	519	7	and	and	CC
cord-023439-r04y1j22	519	8	TNF	TNF	NNP
cord-023439-r04y1j22	519	9	-	-	,
cord-023439-r04y1j22	519	10	a	a	DT
cord-023439-r04y1j22	519	11	inducers	inducer	NNS
cord-023439-r04y1j22	519	12	,	,	,
cord-023439-r04y1j22	519	13	while	while	IN
cord-023439-r04y1j22	519	14	both	both	CC
cord-023439-r04y1j22	519	15	strong	strong	JJ
cord-023439-r04y1j22	519	16	and	and	CC
cord-023439-r04y1j22	519	17	weak	weak	JJ
cord-023439-r04y1j22	519	18	IL-12	IL-12	NNP
cord-023439-r04y1j22	519	19	inducers	inducer	NNS
cord-023439-r04y1j22	519	20	were	be	VBD
cord-023439-r04y1j22	519	21	found	find	VBN
cord-023439-r04y1j22	519	22	among	among	IN
cord-023439-r04y1j22	519	23	the	the	DT
cord-023439-r04y1j22	519	24	strains	strain	NNS
cord-023439-r04y1j22	519	25	of	of	IN
cord-023439-r04y1j22	519	26	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	519	27	.	.	.
cord-023439-r04y1j22	520	1	Remarkably	remarkably	RB
cord-023439-r04y1j22	520	2	,	,	,
cord-023439-r04y1j22	520	3	strains	strain	NNS
cord-023439-r04y1j22	520	4	weak	weak	JJ
cord-023439-r04y1j22	520	5	in	in	IN
cord-023439-r04y1j22	520	6	IL-12	IL-12	NNP
cord-023439-r04y1j22	520	7	induction	induction	NN
cord-023439-r04y1j22	520	8	inhibited	inhibit	VBN
cord-023439-r04y1j22	520	9	IL-12	IL-12	NNP
cord-023439-r04y1j22	520	10	and	and	CC
cord-023439-r04y1j22	520	11	TNF	TNF	NNP
cord-023439-r04y1j22	520	12	-	-	:
cord-023439-r04y1j22	520	13	a	a	DT
cord-023439-r04y1j22	520	14	production	production	NN
cord-023439-r04y1j22	520	15	induced	induce	VBN
cord-023439-r04y1j22	520	16	by	by	IN
cord-023439-r04y1j22	520	17	an	an	DT
cord-023439-r04y1j22	520	18	otherwise	otherwise	RB
cord-023439-r04y1j22	520	19	strong	strong	JJ
cord-023439-r04y1j22	520	20	cytokine	cytokine	NN
cord-023439-r04y1j22	520	21	-	-	HYPH
cord-023439-r04y1j22	520	22	inducing	induce	VBG
cord-023439-r04y1j22	520	23	strain	strain	NN
cord-023439-r04y1j22	520	24	of	of	IN
cord-023439-r04y1j22	520	25	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	520	26	casei	casei	NN
cord-023439-r04y1j22	520	27	,	,	,
cord-023439-r04y1j22	520	28	while	while	IN
cord-023439-r04y1j22	520	29	IL-10	IL-10	NNP
cord-023439-r04y1j22	520	30	production	production	NN
cord-023439-r04y1j22	520	31	remained	remain	VBD
cord-023439-r04y1j22	520	32	unaltered	unaltered	JJ
cord-023439-r04y1j22	520	33	.	.	.
cord-023439-r04y1j22	521	1	Selected	select	VBN
cord-023439-r04y1j22	521	2	strains	strain	NNS
cord-023439-r04y1j22	521	3	were	be	VBD
cord-023439-r04y1j22	521	4	tested	test	VBN
cord-023439-r04y1j22	521	5	for	for	IN
cord-023439-r04y1j22	521	6	induction	induction	NN
cord-023439-r04y1j22	521	7	of	of	IN
cord-023439-r04y1j22	521	8	DC	DC	NNP
cord-023439-r04y1j22	521	9	maturation	maturation	NN
cord-023439-r04y1j22	521	10	markers	marker	NNS
cord-023439-r04y1j22	521	11	.	.	.
cord-023439-r04y1j22	522	1	Those	those	DT
cord-023439-r04y1j22	522	2	lactobacilli	lactobacillus	NNS
cord-023439-r04y1j22	522	3	with	with	IN
cord-023439-r04y1j22	522	4	greatest	great	JJS
cord-023439-r04y1j22	522	5	capacity	capacity	NN
cord-023439-r04y1j22	522	6	to	to	TO
cord-023439-r04y1j22	522	7	induce	induce	VB
cord-023439-r04y1j22	522	8	IL-12	IL-12	NNP
cord-023439-r04y1j22	522	9	were	be	VBD
cord-023439-r04y1j22	522	10	most	most	RBS
cord-023439-r04y1j22	522	11	effective	effective	JJ
cord-023439-r04y1j22	522	12	in	in	IN
cord-023439-r04y1j22	522	13	upregulating	upregulate	VBG
cord-023439-r04y1j22	522	14	surface	surface	NN
cord-023439-r04y1j22	522	15	MHC	MHC	NNP
cord-023439-r04y1j22	522	16	class	class	NN
cord-023439-r04y1j22	522	17	II	II	NNP
cord-023439-r04y1j22	522	18	and	and	CC
cord-023439-r04y1j22	522	19	CD86	CD86	NNP
cord-023439-r04y1j22	522	20	.	.	.
cord-023439-r04y1j22	523	1	Moreover	moreover	RB
cord-023439-r04y1j22	523	2	,	,	,
cord-023439-r04y1j22	523	3	L.	L.	NNP
cord-023439-r04y1j22	523	4	casei	casei	NN
cord-023439-r04y1j22	523	5	-	-	HYPH
cord-023439-r04y1j22	523	6	induced	induce	VBN
cord-023439-r04y1j22	523	7	upregulation	upregulation	NN
cord-023439-r04y1j22	523	8	of	of	IN
cord-023439-r04y1j22	523	9	CD86	CD86	NNP
cord-023439-r04y1j22	523	10	was	be	VBD
cord-023439-r04y1j22	523	11	reduced	reduce	VBN
cord-023439-r04y1j22	523	12	in	in	IN
cord-023439-r04y1j22	523	13	the	the	DT
cord-023439-r04y1j22	523	14	presence	presence	NN
cord-023439-r04y1j22	523	15	of	of	IN
cord-023439-r04y1j22	523	16	a	a	DT
cord-023439-r04y1j22	523	17	weak	weak	JJ
cord-023439-r04y1j22	523	18	IL-12inducing	IL-12inducing	NNP
cord-023439-r04y1j22	523	19	L.	L.	NNP
cord-023439-r04y1j22	523	20	reuteri	reuteri	NN
cord-023439-r04y1j22	523	21	.	.	.
cord-023439-r04y1j22	524	1	In	in	IN
cord-023439-r04y1j22	524	2	conclusion	conclusion	NN
cord-023439-r04y1j22	524	3	,	,	,
cord-023439-r04y1j22	524	4	human	human	JJ
cord-023439-r04y1j22	524	5	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	524	6	and	and	CC
cord-023439-r04y1j22	524	7	Bifidobacterium	bifidobacterium	NN
cord-023439-r04y1j22	524	8	spp	spp	NNS
cord-023439-r04y1j22	524	9	.	.	.
cord-023439-r04y1j22	524	10	polarize	polarize	VB
cord-023439-r04y1j22	524	11	differentially	differentially	RB
cord-023439-r04y1j22	524	12	DC	DC	NNP
cord-023439-r04y1j22	524	13	maturation	maturation	NN
cord-023439-r04y1j22	524	14	.	.	.
cord-023439-r04y1j22	525	1	Thus	thus	RB
cord-023439-r04y1j22	525	2	,	,	,
cord-023439-r04y1j22	525	3	the	the	DT
cord-023439-r04y1j22	525	4	potential	potential	NN
cord-023439-r04y1j22	525	5	exists	exist	VBZ
cord-023439-r04y1j22	525	6	for	for	IN
cord-023439-r04y1j22	525	7	Th1	th1	NN
cord-023439-r04y1j22	525	8	/	/	SYM
cord-023439-r04y1j22	525	9	Th2	Th2	NNP
cord-023439-r04y1j22	525	10	/	/	SYM
cord-023439-r04y1j22	525	11	Treg	Treg	NNP
cord-023439-r04y1j22	525	12	-	-	HYPH
cord-023439-r04y1j22	525	13	driving	drive	VBG
cord-023439-r04y1j22	525	14	capacities	capacity	NNS
cord-023439-r04y1j22	525	15	of	of	IN
cord-023439-r04y1j22	525	16	the	the	DT
cord-023439-r04y1j22	525	17	gut	gut	NN
cord-023439-r04y1j22	525	18	DC	DC	NNP
cord-023439-r04y1j22	525	19	to	to	TO
cord-023439-r04y1j22	525	20	be	be	VB
cord-023439-r04y1j22	525	21	modulated	modulate	VBN
cord-023439-r04y1j22	525	22	according	accord	VBG
cord-023439-r04y1j22	525	23	to	to	IN
cord-023439-r04y1j22	525	24	composition	composition	NN
cord-023439-r04y1j22	525	25	of	of	IN
cord-023439-r04y1j22	525	26	gut	gut	NN
cord-023439-r04y1j22	525	27	flora	flora	NNS
cord-023439-r04y1j22	525	28	including	include	VBG
cord-023439-r04y1j22	525	29	ingested	ingest	VBN
cord-023439-r04y1j22	525	30	probiotics	probiotic	NNS
cord-023439-r04y1j22	525	31	.	.	.
cord-023439-r04y1j22	526	1	The	the	DT
cord-023439-r04y1j22	526	2	intestinal	intestinal	JJ
cord-023439-r04y1j22	526	3	micro	micro	NN
cord-023439-r04y1j22	526	4	flora	flora	NNP
cord-023439-r04y1j22	526	5	is	be	VBZ
cord-023439-r04y1j22	526	6	indispensable	indispensable	JJ
cord-023439-r04y1j22	526	7	in	in	IN
cord-023439-r04y1j22	526	8	developing	develop	VBG
cord-023439-r04y1j22	526	9	and	and	CC
cord-023439-r04y1j22	526	10	maintaining	maintain	VBG
cord-023439-r04y1j22	526	11	homeostasis	homeostasis	NN
cord-023439-r04y1j22	526	12	of	of	IN
cord-023439-r04y1j22	526	13	the	the	DT
cord-023439-r04y1j22	526	14	gut	gut	NN
cord-023439-r04y1j22	526	15	-	-	HYPH
cord-023439-r04y1j22	526	16	associated	associate	VBN
cord-023439-r04y1j22	526	17	immune	immune	JJ
cord-023439-r04y1j22	526	18	system	system	NN
cord-023439-r04y1j22	526	19	.	.	.
cord-023439-r04y1j22	527	1	Evidence	evidence	NN
cord-023439-r04y1j22	527	2	indicates	indicate	VBZ
cord-023439-r04y1j22	527	3	that	that	IN
cord-023439-r04y1j22	527	4	lactic	lactic	JJ
cord-023439-r04y1j22	527	5	acid	acid	NN
cord-023439-r04y1j22	527	6	bacteria	bacteria	NNS
cord-023439-r04y1j22	527	7	(	(	-LRB-
cord-023439-r04y1j22	527	8	LAB	lab	NN
cord-023439-r04y1j22	527	9	)	)	-RRB-
cord-023439-r04y1j22	527	10	,	,	,
cord-023439-r04y1j22	527	11	e.g.	e.g.	IN
cord-023439-r04y1j22	527	12	lactobacilli	lactobacilli	NN
cord-023439-r04y1j22	527	13	and	and	CC
cord-023439-r04y1j22	527	14	bifidobacteria	bifidobacteria	NNP
cord-023439-r04y1j22	527	15	,	,	,
cord-023439-r04y1j22	527	16	have	have	VBP
cord-023439-r04y1j22	527	17	beneficial	beneficial	JJ
cord-023439-r04y1j22	527	18	effects	effect	NNS
cord-023439-r04y1j22	527	19	on	on	IN
cord-023439-r04y1j22	527	20	the	the	DT
cord-023439-r04y1j22	527	21	host	host	NN
cord-023439-r04y1j22	527	22	.	.	.
cord-023439-r04y1j22	528	1	Established	establish	VBN
cord-023439-r04y1j22	528	2	health	health	NN
cord-023439-r04y1j22	528	3	effects	effect	NNS
cord-023439-r04y1j22	528	4	include	include	VBP
cord-023439-r04y1j22	528	5	increased	increase	VBN
cord-023439-r04y1j22	528	6	gut	gut	NN
cord-023439-r04y1j22	528	7	maturation	maturation	NN
cord-023439-r04y1j22	528	8	,	,	,
cord-023439-r04y1j22	528	9	antagonisms	antagonism	NNS
cord-023439-r04y1j22	528	10	towards	towards	IN
cord-023439-r04y1j22	528	11	pathogens	pathogen	NNS
cord-023439-r04y1j22	528	12	and	and	CC
cord-023439-r04y1j22	528	13	immune	immune	JJ
cord-023439-r04y1j22	528	14	modulation	modulation	NN
cord-023439-r04y1j22	528	15	.	.	.
cord-023439-r04y1j22	529	1	The	the	DT
cord-023439-r04y1j22	529	2	objective	objective	NN
cord-023439-r04y1j22	529	3	of	of	IN
cord-023439-r04y1j22	529	4	this	this	DT
cord-023439-r04y1j22	529	5	study	study	NN
cord-023439-r04y1j22	529	6	is	be	VBZ
cord-023439-r04y1j22	529	7	to	to	TO
cord-023439-r04y1j22	529	8	evaluate	evaluate	VB
cord-023439-r04y1j22	529	9	the	the	DT
cord-023439-r04y1j22	529	10	immunomodulating	immunomodulate	VBG
cord-023439-r04y1j22	529	11	properties	property	NNS
cord-023439-r04y1j22	529	12	of	of	IN
cord-023439-r04y1j22	529	13	a	a	DT
cord-023439-r04y1j22	529	14	range	range	NN
cord-023439-r04y1j22	529	15	of	of	IN
cord-023439-r04y1j22	529	16	LAB	lab	NN
cord-023439-r04y1j22	529	17	of	of	IN
cord-023439-r04y1j22	529	18	human	human	JJ
cord-023439-r04y1j22	529	19	origin	origin	NN
cord-023439-r04y1j22	529	20	.	.	.
cord-023439-r04y1j22	530	1	As	as	IN
cord-023439-r04y1j22	530	2	dendritic	dendritic	JJ
cord-023439-r04y1j22	530	3	cells	cell	NNS
cord-023439-r04y1j22	530	4	(	(	-LRB-
cord-023439-r04y1j22	530	5	DCs	DCs	NNP
cord-023439-r04y1j22	530	6	)	)	-RRB-
cord-023439-r04y1j22	530	7	play	play	VBP
cord-023439-r04y1j22	530	8	a	a	DT
cord-023439-r04y1j22	530	9	pivotal	pivotal	JJ
cord-023439-r04y1j22	530	10	role	role	NN
cord-023439-r04y1j22	530	11	in	in	IN
cord-023439-r04y1j22	530	12	the	the	DT
cord-023439-r04y1j22	530	13	balance	balance	NN
cord-023439-r04y1j22	530	14	between	between	IN
cord-023439-r04y1j22	530	15	tolerance	tolerance	NN
cord-023439-r04y1j22	530	16	and	and	CC
cord-023439-r04y1j22	530	17	immunity	immunity	NN
cord-023439-r04y1j22	530	18	to	to	IN
cord-023439-r04y1j22	530	19	commensal	commensal	JJ
cord-023439-r04y1j22	530	20	microorganisms	microorganism	NNS
cord-023439-r04y1j22	530	21	,	,	,
cord-023439-r04y1j22	530	22	in	in	IN
cord-023439-r04y1j22	530	23	vitro	vitro	FW
cord-023439-r04y1j22	530	24	-	-	HYPH
cord-023439-r04y1j22	530	25	generated	generate	VBN
cord-023439-r04y1j22	530	26	immature	immature	JJ
cord-023439-r04y1j22	530	27	DCs	dc	NNS
cord-023439-r04y1j22	530	28	serve	serve	VBP
cord-023439-r04y1j22	530	29	as	as	IN
cord-023439-r04y1j22	530	30	a	a	DT
cord-023439-r04y1j22	530	31	suitable	suitable	JJ
cord-023439-r04y1j22	530	32	model	model	NN
cord-023439-r04y1j22	530	33	for	for	IN
cord-023439-r04y1j22	530	34	studying	study	VBG
cord-023439-r04y1j22	530	35	the	the	DT
cord-023439-r04y1j22	530	36	immunomodulating	immunomodulating	JJ
cord-023439-r04y1j22	530	37	effects	effect	NNS
cord-023439-r04y1j22	530	38	of	of	IN
cord-023439-r04y1j22	530	39	lab	lab	NN
cord-023439-r04y1j22	530	40	.	.	.
cord-023439-r04y1j22	531	1	Human	human	JJ
cord-023439-r04y1j22	531	2	immature	immature	JJ
cord-023439-r04y1j22	531	3	DCs	dc	NNS
cord-023439-r04y1j22	531	4	were	be	VBD
cord-023439-r04y1j22	531	5	generated	generate	VBN
cord-023439-r04y1j22	531	6	in	in	IN
cord-023439-r04y1j22	531	7	vitro	vitro	FW
cord-023439-r04y1j22	531	8	from	from	IN
cord-023439-r04y1j22	531	9	monocytes	monocyte	NNS
cord-023439-r04y1j22	531	10	and	and	CC
cord-023439-r04y1j22	531	11	exposed	expose	VBN
cord-023439-r04y1j22	531	12	to	to	IN
cord-023439-r04y1j22	531	13	lethally	lethally	RB
cord-023439-r04y1j22	531	14	UV	uv	NN
cord-023439-r04y1j22	531	15	-	-	HYPH
cord-023439-r04y1j22	531	16	irradiated	irradiate	VBN
cord-023439-r04y1j22	531	17	LAB	lab	NN
cord-023439-r04y1j22	531	18	.	.	.
cord-023439-r04y1j22	532	1	The	the	DT
cord-023439-r04y1j22	532	2	effect	effect	NN
cord-023439-r04y1j22	532	3	of	of	IN
cord-023439-r04y1j22	532	4	various	various	JJ
cord-023439-r04y1j22	532	5	species	specie	NNS
cord-023439-r04y1j22	532	6	of	of	IN
cord-023439-r04y1j22	532	7	LAB	lab	NN
cord-023439-r04y1j22	532	8	on	on	IN
cord-023439-r04y1j22	532	9	DCs	dc	NNS
cord-023439-r04y1j22	532	10	in	in	IN
cord-023439-r04y1j22	532	11	direct	direct	JJ
cord-023439-r04y1j22	532	12	contact	contact	NN
cord-023439-r04y1j22	532	13	was	be	VBD
cord-023439-r04y1j22	532	14	evaluated	evaluate	VBN
cord-023439-r04y1j22	532	15	.	.	.
cord-023439-r04y1j22	533	1	Furthermore	furthermore	RB
cord-023439-r04y1j22	533	2	,	,	,
cord-023439-r04y1j22	533	3	the	the	DT
cord-023439-r04y1j22	533	4	maturation	maturation	NN
cord-023439-r04y1j22	533	5	pattern	pattern	NN
cord-023439-r04y1j22	533	6	of	of	IN
cord-023439-r04y1j22	533	7	DCs	dc	NNS
cord-023439-r04y1j22	533	8	separated	separate	VBD
cord-023439-r04y1j22	533	9	from	from	IN
cord-023439-r04y1j22	533	10	the	the	DT
cord-023439-r04y1j22	533	11	bacteria	bacteria	NNS
cord-023439-r04y1j22	533	12	by	by	IN
cord-023439-r04y1j22	533	13	an	an	DT
cord-023439-r04y1j22	533	14	epithelial	epithelial	JJ
cord-023439-r04y1j22	533	15	cell	cell	NN
cord-023439-r04y1j22	533	16	layer	layer	NN
cord-023439-r04y1j22	533	17	(	(	-LRB-
cord-023439-r04y1j22	533	18	CaCo-2	CaCo-2	NNP
cord-023439-r04y1j22	533	19	cells	cell	NNS
cord-023439-r04y1j22	533	20	)	)	-RRB-
cord-023439-r04y1j22	533	21	,	,	,
cord-023439-r04y1j22	533	22	which	which	WDT
cord-023439-r04y1j22	533	23	should	should	MD
cord-023439-r04y1j22	533	24	mimic	mimic	VB
cord-023439-r04y1j22	533	25	the	the	DT
cord-023439-r04y1j22	533	26	intestinal	intestinal	JJ
cord-023439-r04y1j22	533	27	environment	environment	NN
cord-023439-r04y1j22	533	28	,	,	,
cord-023439-r04y1j22	533	29	was	be	VBD
cord-023439-r04y1j22	533	30	studied	study	VBN
cord-023439-r04y1j22	533	31	.	.	.
cord-023439-r04y1j22	534	1	Cytokine	cytokine	NN
cord-023439-r04y1j22	534	2	secretion	secretion	NN
cord-023439-r04y1j22	534	3	(	(	-LRB-
cord-023439-r04y1j22	534	4	IL-12	IL-12	NNP
cord-023439-r04y1j22	534	5	,	,	,
cord-023439-r04y1j22	534	6	IL-10	IL-10	NNP
cord-023439-r04y1j22	534	7	and	and	CC
cord-023439-r04y1j22	534	8	TNF	TNF	NNP
cord-023439-r04y1j22	534	9	-	-	HYPH
cord-023439-r04y1j22	534	10	a	a	LS
cord-023439-r04y1j22	534	11	)	)	-RRB-
cord-023439-r04y1j22	534	12	and	and	CC
cord-023439-r04y1j22	534	13	upregulation	upregulation	NN
cord-023439-r04y1j22	534	14	of	of	IN
cord-023439-r04y1j22	534	15	maturation	maturation	NN
cord-023439-r04y1j22	534	16	surface	surface	NN
cord-023439-r04y1j22	534	17	markers	marker	NNS
cord-023439-r04y1j22	534	18	on	on	IN
cord-023439-r04y1j22	534	19	DCs	DCs	NNP
cord-023439-r04y1j22	534	20	(	(	-LRB-
cord-023439-r04y1j22	534	21	CD83	CD83	NNP
cord-023439-r04y1j22	534	22	and	and	CC
cord-023439-r04y1j22	534	23	CD86	CD86	NNP
cord-023439-r04y1j22	534	24	)	)	-RRB-
cord-023439-r04y1j22	534	25	was	be	VBD
cord-023439-r04y1j22	534	26	measured	measure	VBN
cord-023439-r04y1j22	534	27	.	.	.
cord-023439-r04y1j22	535	1	Different	different	JJ
cord-023439-r04y1j22	535	2	LAB	lab	NN
cord-023439-r04y1j22	535	3	induced	induce	VBN
cord-023439-r04y1j22	535	4	diverse	diverse	JJ
cord-023439-r04y1j22	535	5	cytokine	cytokine	NN
cord-023439-r04y1j22	535	6	responses	response	NNS
cord-023439-r04y1j22	535	7	.	.	.
cord-023439-r04y1j22	536	1	Some	some	DT
cord-023439-r04y1j22	536	2	strains	strain	NNS
cord-023439-r04y1j22	536	3	were	be	VBD
cord-023439-r04y1j22	536	4	strong	strong	JJ
cord-023439-r04y1j22	536	5	IL-12	IL-12	NNP
cord-023439-r04y1j22	536	6	and	and	CC
cord-023439-r04y1j22	536	7	TNF	TNF	NNP
cord-023439-r04y1j22	536	8	-	-	,
cord-023439-r04y1j22	536	9	a	a	DT
cord-023439-r04y1j22	536	10	inducers	inducer	NNS
cord-023439-r04y1j22	536	11	and	and	CC
cord-023439-r04y1j22	536	12	others	other	NNS
cord-023439-r04y1j22	536	13	weak	weak	JJ
cord-023439-r04y1j22	536	14	.	.	.
cord-023439-r04y1j22	537	1	All	all	DT
cord-023439-r04y1j22	537	2	strains	strain	NNS
cord-023439-r04y1j22	537	3	induced	induce	VBN
cord-023439-r04y1j22	537	4	IL-10	IL-10	NNP
cord-023439-r04y1j22	537	5	.	.	.
cord-023439-r04y1j22	538	1	Different	different	JJ
cord-023439-r04y1j22	538	2	LAB	lab	NN
cord-023439-r04y1j22	538	3	also	also	RB
cord-023439-r04y1j22	538	4	differentially	differentially	RB
cord-023439-r04y1j22	538	5	modulated	modulate	VBN
cord-023439-r04y1j22	538	6	expression	expression	NN
cord-023439-r04y1j22	538	7	of	of	IN
cord-023439-r04y1j22	538	8	CD83	CD83	NNP
cord-023439-r04y1j22	538	9	and	and	CC
cord-023439-r04y1j22	538	10	CD86	CD86	NNP
cord-023439-r04y1j22	538	11	on	on	IN
cord-023439-r04y1j22	538	12	DCs	dc	NNS
cord-023439-r04y1j22	538	13	.	.	.
cord-023439-r04y1j22	539	1	Although	although	IN
cord-023439-r04y1j22	539	2	some	some	DT
cord-023439-r04y1j22	539	3	variation	variation	NN
cord-023439-r04y1j22	539	4	in	in	IN
cord-023439-r04y1j22	539	5	the	the	DT
cord-023439-r04y1j22	539	6	response	response	NN
cord-023439-r04y1j22	539	7	to	to	IN
cord-023439-r04y1j22	539	8	LAB	LAB	NNP
cord-023439-r04y1j22	539	9	of	of	IN
cord-023439-r04y1j22	539	10	DCs	dc	NNS
cord-023439-r04y1j22	539	11	generated	generate	VBN
cord-023439-r04y1j22	539	12	from	from	IN
cord-023439-r04y1j22	539	13	different	different	JJ
cord-023439-r04y1j22	539	14	blood	blood	NN
cord-023439-r04y1j22	539	15	donors	donor	NNS
cord-023439-r04y1j22	539	16	was	be	VBD
cord-023439-r04y1j22	539	17	observed	observe	VBN
cord-023439-r04y1j22	539	18	,	,	,
cord-023439-r04y1j22	539	19	general	general	JJ
cord-023439-r04y1j22	539	20	differences	difference	NNS
cord-023439-r04y1j22	539	21	in	in	IN
cord-023439-r04y1j22	539	22	the	the	DT
cord-023439-r04y1j22	539	23	effect	effect	NN
cord-023439-r04y1j22	539	24	of	of	IN
cord-023439-r04y1j22	539	25	the	the	DT
cord-023439-r04y1j22	539	26	various	various	JJ
cord-023439-r04y1j22	539	27	LAB	lab	NN
cord-023439-r04y1j22	539	28	was	be	VBD
cord-023439-r04y1j22	539	29	revealed	reveal	VBN
cord-023439-r04y1j22	539	30	.	.	.
cord-023439-r04y1j22	540	1	Experiments	experiment	NNS
cord-023439-r04y1j22	540	2	with	with	IN
cord-023439-r04y1j22	540	3	the	the	DT
cord-023439-r04y1j22	540	4	DC	DC	NNP
cord-023439-r04y1j22	540	5	CaCo-2	CaCo-2	NNP
cord-023439-r04y1j22	540	6	coculture	coculture	NN
cord-023439-r04y1j22	540	7	system	system	NN
cord-023439-r04y1j22	540	8	are	be	VBP
cord-023439-r04y1j22	540	9	ongoing	ongoing	JJ
cord-023439-r04y1j22	540	10	.	.	.
cord-023439-r04y1j22	541	1	Different	different	JJ
cord-023439-r04y1j22	541	2	species	specie	NNS
cord-023439-r04y1j22	541	3	of	of	IN
cord-023439-r04y1j22	541	4	LAB	lab	NN
cord-023439-r04y1j22	541	5	differentially	differentially	RB
cord-023439-r04y1j22	541	6	affect	affect	VBP
cord-023439-r04y1j22	541	7	DC	DC	NNP
cord-023439-r04y1j22	541	8	maturation	maturation	NN
cord-023439-r04y1j22	541	9	;	;	:
cord-023439-r04y1j22	541	10	this	this	DT
cord-023439-r04y1j22	541	11	suggets	sugget	VBZ
cord-023439-r04y1j22	541	12	that	that	IN
cord-023439-r04y1j22	541	13	the	the	DT
cord-023439-r04y1j22	541	14	gut	gut	NN
cord-023439-r04y1j22	541	15	flora	flora	NN
cord-023439-r04y1j22	541	16	plays	play	VBZ
cord-023439-r04y1j22	541	17	a	a	DT
cord-023439-r04y1j22	541	18	pivotal	pivotal	JJ
cord-023439-r04y1j22	541	19	role	role	NN
cord-023439-r04y1j22	541	20	in	in	IN
cord-023439-r04y1j22	541	21	polarization	polarization	NN
cord-023439-r04y1j22	541	22	of	of	IN
cord-023439-r04y1j22	541	23	the	the	DT
cord-023439-r04y1j22	541	24	immune	immune	JJ
cord-023439-r04y1j22	541	25	response	response	NN
cord-023439-r04y1j22	541	26	.	.	.
cord-023439-r04y1j22	542	1	Natural	natural	JJ
cord-023439-r04y1j22	542	2	killer	killer	NN
cord-023439-r04y1j22	542	3	(	(	-LRB-
cord-023439-r04y1j22	542	4	NK	NK	NNP
cord-023439-r04y1j22	542	5	)	)	-RRB-
cord-023439-r04y1j22	542	6	cells	cell	NNS
cord-023439-r04y1j22	542	7	are	be	VBP
cord-023439-r04y1j22	542	8	cells	cell	NNS
cord-023439-r04y1j22	542	9	of	of	IN
cord-023439-r04y1j22	542	10	the	the	DT
cord-023439-r04y1j22	542	11	nonspecific	nonspecific	JJ
cord-023439-r04y1j22	542	12	immune	immune	JJ
cord-023439-r04y1j22	542	13	system	system	NN
cord-023439-r04y1j22	542	14	lysing	lyse	VBG
cord-023439-r04y1j22	542	15	altered	alter	VBD
cord-023439-r04y1j22	542	16	self	self	NN
cord-023439-r04y1j22	542	17	-	-	HYPH
cord-023439-r04y1j22	542	18	cells	cell	NNS
cord-023439-r04y1j22	542	19	.	.	.
cord-023439-r04y1j22	543	1	A	a	DT
cord-023439-r04y1j22	543	2	noncytolytic	noncytolytic	JJ
cord-023439-r04y1j22	543	3	subset	subset	VBN
cord-023439-r04y1j22	543	4	of	of	IN
cord-023439-r04y1j22	543	5	NK	NK	NNP
cord-023439-r04y1j22	543	6	cells	cell	NNS
cord-023439-r04y1j22	543	7	may	may	MD
cord-023439-r04y1j22	543	8	serve	serve	VB
cord-023439-r04y1j22	543	9	a	a	DT
cord-023439-r04y1j22	543	10	regulatory	regulatory	JJ
cord-023439-r04y1j22	543	11	role	role	NN
cord-023439-r04y1j22	543	12	by	by	IN
cord-023439-r04y1j22	543	13	secreting	secrete	VBG
cord-023439-r04y1j22	543	14	cytokines	cytokine	NNS
cord-023439-r04y1j22	543	15	.	.	.
cord-023439-r04y1j22	544	1	Bacteria	Bacteria	NNS
cord-023439-r04y1j22	544	2	translocating	translocate	VBG
cord-023439-r04y1j22	544	3	across	across	IN
cord-023439-r04y1j22	544	4	the	the	DT
cord-023439-r04y1j22	544	5	gastrointestinal	gastrointestinal	JJ
cord-023439-r04y1j22	544	6	mucosa	mucosa	NN
cord-023439-r04y1j22	544	7	are	be	VBP
cord-023439-r04y1j22	544	8	presumed	presume	VBN
cord-023439-r04y1j22	544	9	to	to	TO
cord-023439-r04y1j22	544	10	gain	gain	VB
cord-023439-r04y1j22	544	11	access	access	NN
cord-023439-r04y1j22	544	12	to	to	IN
cord-023439-r04y1j22	544	13	NK	NK	NNP
cord-023439-r04y1j22	544	14	cells	cell	NNS
cord-023439-r04y1j22	544	15	,	,	,
cord-023439-r04y1j22	544	16	as	as	IN
cord-023439-r04y1j22	544	17	consumption	consumption	NN
cord-023439-r04y1j22	544	18	of	of	IN
cord-023439-r04y1j22	544	19	certain	certain	JJ
cord-023439-r04y1j22	544	20	lactic	lactic	JJ
cord-023439-r04y1j22	544	21	acid	acid	NN
cord-023439-r04y1j22	544	22	bacteria	bacteria	NNS
cord-023439-r04y1j22	544	23	has	have	VBZ
cord-023439-r04y1j22	544	24	been	be	VBN
cord-023439-r04y1j22	544	25	shown	show	VBN
cord-023439-r04y1j22	544	26	to	to	TO
cord-023439-r04y1j22	544	27	increase	increase	VB
cord-023439-r04y1j22	544	28	in	in	IN
cord-023439-r04y1j22	544	29	vivo	vivo	NN
cord-023439-r04y1j22	544	30	NK	nk	NN
cord-023439-r04y1j22	544	31	cytotoxicity	cytotoxicity	NN
cord-023439-r04y1j22	544	32	.	.	.
cord-023439-r04y1j22	545	1	Here	here	RB
cord-023439-r04y1j22	545	2	,	,	,
cord-023439-r04y1j22	545	3	we	-PRON-	PRP
cord-023439-r04y1j22	545	4	investigated	investigate	VBD
cord-023439-r04y1j22	545	5	how	how	WRB
cord-023439-r04y1j22	545	6	human	human	JJ
cord-023439-r04y1j22	545	7	gut	gut	NN
cord-023439-r04y1j22	545	8	flora	flora	NNS
cord-023439-r04y1j22	545	9	-	-	HYPH
cord-023439-r04y1j22	545	10	derived	derive	VBN
cord-023439-r04y1j22	545	11	lactobacilli	lactobacilli	NN
cord-023439-r04y1j22	545	12	affect	affect	VBP
cord-023439-r04y1j22	545	13	NK	NK	NNP
cord-023439-r04y1j22	545	14	cells	cell	NNS
cord-023439-r04y1j22	545	15	in	in	IN
cord-023439-r04y1j22	545	16	vitro	vitro	FW
cord-023439-r04y1j22	545	17	,	,	,
cord-023439-r04y1j22	545	18	by	by	IN
cord-023439-r04y1j22	545	19	measuring	measure	VBG
cord-023439-r04y1j22	545	20	proliferation	proliferation	NN
cord-023439-r04y1j22	545	21	and	and	CC
cord-023439-r04y1j22	545	22	IFN	IFN	NNP
cord-023439-r04y1j22	545	23	-	-	HYPH
cord-023439-r04y1j22	545	24	g	g	NN
cord-023439-r04y1j22	545	25	production	production	NN
cord-023439-r04y1j22	545	26	of	of	IN
cord-023439-r04y1j22	545	27	human	human	JJ
cord-023439-r04y1j22	545	28	NK	NK	NNP
cord-023439-r04y1j22	545	29	cells	cell	NNS
cord-023439-r04y1j22	545	30	upon	upon	IN
cord-023439-r04y1j22	545	31	bacterial	bacterial	JJ
cord-023439-r04y1j22	545	32	stimulation	stimulation	NN
cord-023439-r04y1j22	545	33	.	.	.
cord-023439-r04y1j22	546	1	CD3	CD3	NNP
cord-023439-r04y1j22	546	2	-CD56	-CD56	NNP
cord-023439-r04y1j22	546	3	þ	þ	NNP
cord-023439-r04y1j22	546	4	NK	NK	NNP
cord-023439-r04y1j22	546	5	cells	cell	NNS
cord-023439-r04y1j22	546	6	were	be	VBD
cord-023439-r04y1j22	546	7	isolated	isolate	VBN
cord-023439-r04y1j22	546	8	from	from	IN
cord-023439-r04y1j22	546	9	buffy	buffy	NNP
cord-023439-r04y1j22	546	10	coats	coat	NNS
cord-023439-r04y1j22	546	11	by	by	IN
cord-023439-r04y1j22	546	12	negative	negative	JJ
cord-023439-r04y1j22	546	13	isolation	isolation	NN
cord-023439-r04y1j22	546	14	using	use	VBG
cord-023439-r04y1j22	546	15	non	non	JJ
cord-023439-r04y1j22	546	16	-	-	JJ
cord-023439-r04y1j22	546	17	NK	nk	JJ
cord-023439-r04y1j22	546	18	lineage	lineage	NN
cord-023439-r04y1j22	546	19	-	-	HYPH
cord-023439-r04y1j22	546	20	specific	specific	JJ
cord-023439-r04y1j22	546	21	antibodies	antibody	NNS
cord-023439-r04y1j22	546	22	and	and	CC
cord-023439-r04y1j22	546	23	magnetic	magnetic	JJ
cord-023439-r04y1j22	546	24	beads	bead	NNS
cord-023439-r04y1j22	546	25	.	.	.
cord-023439-r04y1j22	547	1	NK	NK	NNP
cord-023439-r04y1j22	547	2	cells	cell	NNS
cord-023439-r04y1j22	547	3	were	be	VBD
cord-023439-r04y1j22	547	4	incubated	incubate	VBN
cord-023439-r04y1j22	547	5	with	with	IN
cord-023439-r04y1j22	547	6	10mg	10mg	NNP
cord-023439-r04y1j22	547	7	/	/	SYM
cord-023439-r04y1j22	547	8	ml	ml	NN
cord-023439-r04y1j22	547	9	UV	uv	NN
cord-023439-r04y1j22	547	10	-	-	HYPH
cord-023439-r04y1j22	547	11	inactivated	inactivate	VBN
cord-023439-r04y1j22	547	12	bacteria	bacteria	NNS
cord-023439-r04y1j22	547	13	or	or	CC
cord-023439-r04y1j22	547	14	10mg	10mg	NN
cord-023439-r04y1j22	547	15	/	/	SYM
cord-023439-r04y1j22	547	16	ml	ml	NN
cord-023439-r04y1j22	547	17	phytohemagglutinin	phytohemagglutinin	NNP
cord-023439-r04y1j22	547	18	(	(	-LRB-
cord-023439-r04y1j22	547	19	PHA	PHA	NNP
cord-023439-r04y1j22	547	20	)	)	-RRB-
cord-023439-r04y1j22	547	21	for	for	IN
cord-023439-r04y1j22	547	22	4	4	CD
cord-023439-r04y1j22	547	23	days	day	NNS
cord-023439-r04y1j22	547	24	.	.	.
cord-023439-r04y1j22	548	1	Proliferation	proliferation	NN
cord-023439-r04y1j22	548	2	was	be	VBD
cord-023439-r04y1j22	548	3	assessed	assess	VBN
cord-023439-r04y1j22	548	4	by	by	IN
cord-023439-r04y1j22	548	5	incorporation	incorporation	NN
cord-023439-r04y1j22	548	6	of	of	IN
cord-023439-r04y1j22	548	7	radioactive	radioactive	JJ
cord-023439-r04y1j22	548	8	thymidine	thymidine	NN
cord-023439-r04y1j22	548	9	into	into	IN
cord-023439-r04y1j22	548	10	NK	nk	NN
cord-023439-r04y1j22	548	11	-	-	HYPH
cord-023439-r04y1j22	548	12	cell	cell	NN
cord-023439-r04y1j22	548	13	DNA	dna	NN
cord-023439-r04y1j22	548	14	.	.	.
cord-023439-r04y1j22	549	1	The	the	DT
cord-023439-r04y1j22	549	2	IFN	IFN	NNP
cord-023439-r04y1j22	549	3	-	-	HYPH
cord-023439-r04y1j22	549	4	g	g	NN
cord-023439-r04y1j22	549	5	concentration	concentration	NN
cord-023439-r04y1j22	549	6	was	be	VBD
cord-023439-r04y1j22	549	7	measured	measure	VBN
cord-023439-r04y1j22	549	8	by	by	IN
cord-023439-r04y1j22	549	9	ELISA	ELISA	NNP
cord-023439-r04y1j22	549	10	.	.	.
cord-023439-r04y1j22	550	1	Incubation	Incubation	NNP
cord-023439-r04y1j22	550	2	of	of	IN
cord-023439-r04y1j22	550	3	NK	NK	NNP
cord-023439-r04y1j22	550	4	cells	cell	NNS
cord-023439-r04y1j22	550	5	with	with	IN
cord-023439-r04y1j22	550	6	a	a	DT
cord-023439-r04y1j22	550	7	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	550	8	acidophilus	acidophilus	NN
cord-023439-r04y1j22	550	9	strain	strain	NN
cord-023439-r04y1j22	550	10	increased	increase	VBD
cord-023439-r04y1j22	550	11	the	the	DT
cord-023439-r04y1j22	550	12	proliferation	proliferation	NN
cord-023439-r04y1j22	550	13	of	of	IN
cord-023439-r04y1j22	550	14	the	the	DT
cord-023439-r04y1j22	550	15	NK	NK	NNP
cord-023439-r04y1j22	550	16	cells	cell	NNS
cord-023439-r04y1j22	550	17	and	and	CC
cord-023439-r04y1j22	550	18	induced	induce	VBD
cord-023439-r04y1j22	550	19	IFN	IFN	NNP
cord-023439-r04y1j22	550	20	-	-	HYPH
cord-023439-r04y1j22	550	21	g	g	NN
cord-023439-r04y1j22	550	22	production	production	NN
cord-023439-r04y1j22	550	23	,	,	,
cord-023439-r04y1j22	550	24	both	both	DT
cord-023439-r04y1j22	550	25	to	to	IN
cord-023439-r04y1j22	550	26	levels	level	NNS
cord-023439-r04y1j22	550	27	comparable	comparable	JJ
cord-023439-r04y1j22	550	28	to	to	IN
cord-023439-r04y1j22	550	29	PHA	PHA	NNP
cord-023439-r04y1j22	550	30	stimulation	stimulation	NN
cord-023439-r04y1j22	550	31	.	.	.
cord-023439-r04y1j22	551	1	The	the	DT
cord-023439-r04y1j22	551	2	proliferative	proliferative	JJ
cord-023439-r04y1j22	551	3	response	response	NN
cord-023439-r04y1j22	551	4	was	be	VBD
cord-023439-r04y1j22	551	5	further	further	RB
cord-023439-r04y1j22	551	6	enhanced	enhance	VBN
cord-023439-r04y1j22	551	7	with	with	IN
cord-023439-r04y1j22	551	8	autologous	autologous	JJ
cord-023439-r04y1j22	551	9	monocytes	monocyte	NNS
cord-023439-r04y1j22	551	10	present	present	JJ
cord-023439-r04y1j22	551	11	,	,	,
cord-023439-r04y1j22	551	12	probably	probably	RB
cord-023439-r04y1j22	551	13	because	because	IN
cord-023439-r04y1j22	551	14	cytokines	cytokine	NNS
cord-023439-r04y1j22	551	15	,	,	,
cord-023439-r04y1j22	551	16	secreted	secrete	VBN
cord-023439-r04y1j22	551	17	by	by	IN
cord-023439-r04y1j22	551	18	monocytes	monocyte	NNS
cord-023439-r04y1j22	551	19	having	have	VBG
cord-023439-r04y1j22	551	20	engulfed	engulf	VBN
cord-023439-r04y1j22	551	21	bacteria	bacteria	NNS
cord-023439-r04y1j22	551	22	,	,	,
cord-023439-r04y1j22	551	23	stimulated	stimulate	VBD
cord-023439-r04y1j22	551	24	the	the	DT
cord-023439-r04y1j22	551	25	NK	NK	NNP
cord-023439-r04y1j22	551	26	cells	cell	NNS
cord-023439-r04y1j22	551	27	.	.	.
cord-023439-r04y1j22	552	1	In	in	IN
cord-023439-r04y1j22	552	2	contrast	contrast	NN
cord-023439-r04y1j22	552	3	,	,	,
cord-023439-r04y1j22	552	4	a	a	DT
cord-023439-r04y1j22	552	5	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	552	6	paracasei	paracasei	NN
cord-023439-r04y1j22	552	7	strain	strain	NN
cord-023439-r04y1j22	552	8	caused	cause	VBD
cord-023439-r04y1j22	552	9	the	the	DT
cord-023439-r04y1j22	552	10	NK	NK	NNP
cord-023439-r04y1j22	552	11	cells	cell	NNS
cord-023439-r04y1j22	552	12	to	to	TO
cord-023439-r04y1j22	552	13	proliferate	proliferate	VB
cord-023439-r04y1j22	552	14	only	only	RB
cord-023439-r04y1j22	552	15	in	in	IN
cord-023439-r04y1j22	552	16	the	the	DT
cord-023439-r04y1j22	552	17	presence	presence	NN
cord-023439-r04y1j22	552	18	of	of	IN
cord-023439-r04y1j22	552	19	monocytes	monocyte	NNS
cord-023439-r04y1j22	552	20	.	.	.
cord-023439-r04y1j22	553	1	These	these	DT
cord-023439-r04y1j22	553	2	results	result	NNS
cord-023439-r04y1j22	553	3	demonstrate	demonstrate	VBP
cord-023439-r04y1j22	553	4	that	that	IN
cord-023439-r04y1j22	553	5	various	various	JJ
cord-023439-r04y1j22	553	6	strains	strain	NNS
cord-023439-r04y1j22	553	7	of	of	IN
cord-023439-r04y1j22	553	8	lactobacilli	lactobacillus	NNS
cord-023439-r04y1j22	553	9	have	have	VBP
cord-023439-r04y1j22	553	10	the	the	DT
cord-023439-r04y1j22	553	11	capacity	capacity	NN
cord-023439-r04y1j22	553	12	to	to	TO
cord-023439-r04y1j22	553	13	activate	activate	VB
cord-023439-r04y1j22	553	14	NK	NK	NNP
cord-023439-r04y1j22	553	15	cells	cell	NNS
cord-023439-r04y1j22	553	16	in	in	IN
cord-023439-r04y1j22	553	17	vitro	vitro	FW
cord-023439-r04y1j22	553	18	,	,	,
cord-023439-r04y1j22	553	19	in	in	IN
cord-023439-r04y1j22	553	20	a	a	DT
cord-023439-r04y1j22	553	21	monocyte	monocyte	NN
cord-023439-r04y1j22	553	22	-	-	HYPH
cord-023439-r04y1j22	553	23	dependent	dependent	JJ
cord-023439-r04y1j22	553	24	or	or	CC
cord-023439-r04y1j22	553	25	-independent	-independent	JJ
cord-023439-r04y1j22	553	26	way	way	NN
cord-023439-r04y1j22	553	27	.	.	.
cord-023439-r04y1j22	554	1	Hence	hence	RB
cord-023439-r04y1j22	554	2	,	,	,
cord-023439-r04y1j22	554	3	the	the	DT
cord-023439-r04y1j22	554	4	encounter	encounter	NN
cord-023439-r04y1j22	554	5	of	of	IN
cord-023439-r04y1j22	554	6	NK	NK	NNP
cord-023439-r04y1j22	554	7	cells	cell	NNS
cord-023439-r04y1j22	554	8	with	with	IN
cord-023439-r04y1j22	554	9	lactic	lactic	JJ
cord-023439-r04y1j22	554	10	acid	acid	NN
cord-023439-r04y1j22	554	11	bacteria	bacteria	NNS
cord-023439-r04y1j22	554	12	will	will	MD
cord-023439-r04y1j22	554	13	affect	affect	VB
cord-023439-r04y1j22	554	14	NK	NK	NNP
cord-023439-r04y1j22	554	15	-	-	HYPH
cord-023439-r04y1j22	554	16	cell	cell	NN
cord-023439-r04y1j22	554	17	activation	activation	NN
cord-023439-r04y1j22	554	18	.	.	.
cord-023439-r04y1j22	555	1	Such	such	JJ
cord-023439-r04y1j22	555	2	activation	activation	NN
cord-023439-r04y1j22	555	3	of	of	IN
cord-023439-r04y1j22	555	4	NK	NK	NNP
cord-023439-r04y1j22	555	5	cells	cell	NNS
cord-023439-r04y1j22	555	6	may	may	MD
cord-023439-r04y1j22	555	7	potentially	potentially	RB
cord-023439-r04y1j22	555	8	skew	skew	VB
cord-023439-r04y1j22	555	9	an	an	DT
cord-023439-r04y1j22	555	10	on	on	RB
cord-023439-r04y1j22	555	11	-	-	HYPH
cord-023439-r04y1j22	555	12	going	going	NN
cord-023439-r04y1j22	555	13	or	or	CC
cord-023439-r04y1j22	555	14	subsequent	subsequent	JJ
cord-023439-r04y1j22	555	15	immune	immune	JJ
cord-023439-r04y1j22	555	16	response	response	NN
cord-023439-r04y1j22	555	17	towards	towards	IN
cord-023439-r04y1j22	555	18	a	a	DT
cord-023439-r04y1j22	555	19	Th1	th1	CD
cord-023439-r04y1j22	555	20	response	response	NN
cord-023439-r04y1j22	555	21	.	.	.
cord-023439-r04y1j22	556	1	Lactobacilli	Lactobacilli	NNP
cord-023439-r04y1j22	556	2	are	be	VBP
cord-023439-r04y1j22	556	3	nonpathogenic	nonpathogenic	NNP
cord-023439-r04y1j22	556	4	gram	gram	NN
cord-023439-r04y1j22	556	5	-	-	HYPH
cord-023439-r04y1j22	556	6	positive	positive	JJ
cord-023439-r04y1j22	556	7	inhabitants	inhabitant	NNS
cord-023439-r04y1j22	556	8	of	of	IN
cord-023439-r04y1j22	556	9	the	the	DT
cord-023439-r04y1j22	556	10	normal	normal	JJ
cord-023439-r04y1j22	556	11	human	human	JJ
cord-023439-r04y1j22	556	12	intestine	intestine	NN
cord-023439-r04y1j22	556	13	known	know	VBN
cord-023439-r04y1j22	556	14	for	for	IN
cord-023439-r04y1j22	556	15	their	-PRON-	PRP$
cord-023439-r04y1j22	556	16	healthpromoting	healthpromote	VBG
cord-023439-r04y1j22	556	17	effects	effect	NNS
cord-023439-r04y1j22	556	18	.	.	.
cord-023439-r04y1j22	557	1	In	in	IN
cord-023439-r04y1j22	557	2	our	-PRON-	PRP$
cord-023439-r04y1j22	557	3	earlier	early	JJR
cord-023439-r04y1j22	557	4	work	work	NN
cord-023439-r04y1j22	557	5	,	,	,
cord-023439-r04y1j22	557	6	it	-PRON-	PRP
cord-023439-r04y1j22	557	7	is	be	VBZ
cord-023439-r04y1j22	557	8	shown	show	VBN
cord-023439-r04y1j22	557	9	that	that	IN
cord-023439-r04y1j22	557	10	human	human	JJ
cord-023439-r04y1j22	557	11	monoclonal	monoclonal	JJ
cord-023439-r04y1j22	557	12	antibody	antibody	NN
cord-023439-r04y1j22	557	13	isolated	isolate	VBN
cord-023439-r04y1j22	557	14	from	from	IN
cord-023439-r04y1j22	557	15	sera	sera	NNP
cord-023439-r04y1j22	557	16	of	of	IN
cord-023439-r04y1j22	557	17	a	a	DT
cord-023439-r04y1j22	557	18	patient	patient	NN
cord-023439-r04y1j22	557	19	with	with	IN
cord-023439-r04y1j22	557	20	Waldenstrom	Waldenstrom	NNP
cord-023439-r04y1j22	557	21	macroglobulinaemia	macroglobulinaemia	NN
cord-023439-r04y1j22	557	22	possess	possess	VBP
cord-023439-r04y1j22	557	23	innate	innate	JJ
cord-023439-r04y1j22	557	24	antibody	antibody	NN
cord-023439-r04y1j22	557	25	characteristics	characteristic	NNS
cord-023439-r04y1j22	557	26	and	and	CC
cord-023439-r04y1j22	557	27	binds	bind	VBZ
cord-023439-r04y1j22	557	28	to	to	IN
cord-023439-r04y1j22	557	29	lactic	lactic	JJ
cord-023439-r04y1j22	557	30	acid	acid	NN
cord-023439-r04y1j22	557	31	bacteria	bacteria	NNS
cord-023439-r04y1j22	557	32	.	.	.
cord-023439-r04y1j22	558	1	According	accord	VBG
cord-023439-r04y1j22	558	2	to	to	IN
cord-023439-r04y1j22	558	3	the	the	DT
cord-023439-r04y1j22	558	4	immune	immune	JJ
cord-023439-r04y1j22	558	5	network	network	NN
cord-023439-r04y1j22	558	6	model	model	NN
cord-023439-r04y1j22	558	7	,	,	,
cord-023439-r04y1j22	558	8	immunization	immunization	NN
cord-023439-r04y1j22	558	9	with	with	IN
cord-023439-r04y1j22	558	10	this	this	DT
cord-023439-r04y1j22	558	11	bacteria	bacteria	NNS
cord-023439-r04y1j22	558	12	could	could	MD
cord-023439-r04y1j22	558	13	induce	induce	VB
cord-023439-r04y1j22	558	14	the	the	DT
cord-023439-r04y1j22	558	15	perturbations	perturbation	NNS
cord-023439-r04y1j22	558	16	in	in	IN
cord-023439-r04y1j22	558	17	immune	immune	JJ
cord-023439-r04y1j22	558	18	system	system	NN
cord-023439-r04y1j22	558	19	that	that	WDT
cord-023439-r04y1j22	558	20	might	may	MD
cord-023439-r04y1j22	558	21	result	result	VB
cord-023439-r04y1j22	558	22	in	in	IN
cord-023439-r04y1j22	558	23	production	production	NN
cord-023439-r04y1j22	558	24	of	of	IN
cord-023439-r04y1j22	558	25	anti	anti	JJ
cord-023439-r04y1j22	558	26	-	-	JJ
cord-023439-r04y1j22	558	27	Lactobacillus	lactobacillus	JJ
cord-023439-r04y1j22	558	28	antibodies	antibody	NNS
cord-023439-r04y1j22	558	29	,	,	,
cord-023439-r04y1j22	558	30	human	human	JJ
cord-023439-r04y1j22	558	31	monoclonal	monoclonal	JJ
cord-023439-r04y1j22	558	32	antibody	antibody	NN
cord-023439-r04y1j22	558	33	like	like	IN
cord-023439-r04y1j22	558	34	(	(	-LRB-
cord-023439-r04y1j22	558	35	Ab1	ab1	NN
cord-023439-r04y1j22	558	36	)	)	-RRB-
cord-023439-r04y1j22	558	37	and	and	CC
cord-023439-r04y1j22	558	38	anti	anti	JJ
cord-023439-r04y1j22	558	39	-	-	JJ
cord-023439-r04y1j22	558	40	idiotypic	idiotypic	JJ
cord-023439-r04y1j22	558	41	antibody	antibody	NN
cord-023439-r04y1j22	558	42	(	(	-LRB-
cord-023439-r04y1j22	558	43	Ab2	ab2	NN
cord-023439-r04y1j22	558	44	)	)	-RRB-
cord-023439-r04y1j22	558	45	.	.	.
cord-023439-r04y1j22	559	1	In	in	IN
cord-023439-r04y1j22	559	2	this	this	DT
cord-023439-r04y1j22	559	3	study	study	NN
cord-023439-r04y1j22	559	4	,	,	,
cord-023439-r04y1j22	559	5	BALB	BALB	NNP
cord-023439-r04y1j22	559	6	/	/	SYM
cord-023439-r04y1j22	559	7	c	c	NN
cord-023439-r04y1j22	559	8	mice	mouse	NNS
cord-023439-r04y1j22	559	9	were	be	VBD
cord-023439-r04y1j22	559	10	immunized	immunize	VBN
cord-023439-r04y1j22	559	11	with	with	IN
cord-023439-r04y1j22	559	12	two	two	CD
cord-023439-r04y1j22	559	13	doses	dose	NNS
cord-023439-r04y1j22	559	14	of	of	IN
cord-023439-r04y1j22	559	15	bacteria	bacteria	NNS
cord-023439-r04y1j22	559	16	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	559	17	acidophilus	acidophilus	NN
cord-023439-r04y1j22	559	18	in	in	IN
cord-023439-r04y1j22	559	19	complete	complete	JJ
cord-023439-r04y1j22	559	20	and	and	CC
cord-023439-r04y1j22	559	21	incomplete	incomplete	JJ
cord-023439-r04y1j22	559	22	Freund	Freund	NNP
cord-023439-r04y1j22	559	23	's	's	POS
cord-023439-r04y1j22	559	24	adjuvant	adjuvant	NN
cord-023439-r04y1j22	559	25	and	and	CC
cord-023439-r04y1j22	559	26	phosphate	phosphate	NN
cord-023439-r04y1j22	559	27	-	-	HYPH
cord-023439-r04y1j22	559	28	buffered	buffer	VBN
cord-023439-r04y1j22	559	29	saline	saline	NN
cord-023439-r04y1j22	559	30	(	(	-LRB-
cord-023439-r04y1j22	559	31	PBS	PBS	NNP
cord-023439-r04y1j22	559	32	)	)	-RRB-
cord-023439-r04y1j22	559	33	,	,	,
cord-023439-r04y1j22	559	34	respectively	respectively	RB
cord-023439-r04y1j22	559	35	.	.	.
cord-023439-r04y1j22	560	1	Seven	seven	CD
cord-023439-r04y1j22	560	2	days	day	NNS
cord-023439-r04y1j22	560	3	after	after	IN
cord-023439-r04y1j22	560	4	the	the	DT
cord-023439-r04y1j22	560	5	last	last	JJ
cord-023439-r04y1j22	560	6	immunization	immunization	NN
cord-023439-r04y1j22	560	7	,	,	,
cord-023439-r04y1j22	560	8	sera	sera	NNP
cord-023439-r04y1j22	560	9	from	from	IN
cord-023439-r04y1j22	560	10	immunized	immunize	VBN
cord-023439-r04y1j22	560	11	mice	mouse	NNS
cord-023439-r04y1j22	560	12	were	be	VBD
cord-023439-r04y1j22	560	13	collected	collect	VBN
cord-023439-r04y1j22	560	14	and	and	CC
cord-023439-r04y1j22	560	15	the	the	DT
cord-023439-r04y1j22	560	16	presence	presence	NN
cord-023439-r04y1j22	560	17	of	of	IN
cord-023439-r04y1j22	560	18	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	560	19	-	-	HYPH
cord-023439-r04y1j22	560	20	specific	specific	JJ
cord-023439-r04y1j22	560	21	Ab1	ab1	NN
cord-023439-r04y1j22	560	22	and	and	CC
cord-023439-r04y1j22	560	23	Ab2	ab2	NN
cord-023439-r04y1j22	560	24	were	be	VBD
cord-023439-r04y1j22	560	25	determined	determine	VBN
cord-023439-r04y1j22	560	26	by	by	IN
cord-023439-r04y1j22	560	27	ELISAs	elisa	NNS
cord-023439-r04y1j22	560	28	.	.	.
cord-023439-r04y1j22	561	1	In	in	IN
cord-023439-r04y1j22	561	2	the	the	DT
cord-023439-r04y1j22	561	3	sera	sera	NNP
cord-023439-r04y1j22	561	4	of	of	IN
cord-023439-r04y1j22	561	5	immunized	immunize	VBN
cord-023439-r04y1j22	561	6	mice	mouse	NNS
cord-023439-r04y1j22	561	7	,	,	,
cord-023439-r04y1j22	561	8	antibodies	antibody	NNS
cord-023439-r04y1j22	561	9	specific	specific	JJ
cord-023439-r04y1j22	561	10	to	to	IN
cord-023439-r04y1j22	561	11	bacteria	bacteria	NNS
cord-023439-r04y1j22	561	12	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	561	13	acidophilus	acidophilus	NN
cord-023439-r04y1j22	561	14	were	be	VBD
cord-023439-r04y1j22	561	15	shown	show	VBN
cord-023439-r04y1j22	561	16	.	.	.
cord-023439-r04y1j22	562	1	The	the	DT
cord-023439-r04y1j22	562	2	concentration	concentration	NN
cord-023439-r04y1j22	562	3	of	of	IN
cord-023439-r04y1j22	562	4	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	562	5	-	-	HYPH
cord-023439-r04y1j22	562	6	specific	specific	JJ
cord-023439-r04y1j22	562	7	antibodies	antibody	NNS
cord-023439-r04y1j22	562	8	was	be	VBD
cord-023439-r04y1j22	562	9	higher	high	JJR
cord-023439-r04y1j22	562	10	in	in	IN
cord-023439-r04y1j22	562	11	the	the	DT
cord-023439-r04y1j22	562	12	sera	sera	NNP
cord-023439-r04y1j22	562	13	of	of	IN
cord-023439-r04y1j22	562	14	hyperimmunized	hyperimmunize	VBN
cord-023439-r04y1j22	562	15	mice	mouse	NNS
cord-023439-r04y1j22	562	16	(	(	-LRB-
cord-023439-r04y1j22	562	17	mice	mouse	NNS
cord-023439-r04y1j22	562	18	immunized	immunize	VBN
cord-023439-r04y1j22	562	19	with	with	IN
cord-023439-r04y1j22	562	20	1	1	CD
cord-023439-r04y1j22	562	21	mg	mg	NNP
cord-023439-r04y1j22	562	22	of	of	IN
cord-023439-r04y1j22	562	23	IgM	IgM	NNP
cord-023439-r04y1j22	562	24	DJ	DJ	NNP
cord-023439-r04y1j22	562	25	)	)	-RRB-
cord-023439-r04y1j22	562	26	than	than	IN
cord-023439-r04y1j22	562	27	in	in	IN
cord-023439-r04y1j22	562	28	sera	sera	NNP
cord-023439-r04y1j22	562	29	of	of	IN
cord-023439-r04y1j22	562	30	mice	mouse	NNS
cord-023439-r04y1j22	562	31	immunized	immunize	VBN
cord-023439-r04y1j22	562	32	with	with	IN
cord-023439-r04y1j22	562	33	100	100	CD
cord-023439-r04y1j22	562	34	times	time	NNS
cord-023439-r04y1j22	562	35	lower	low	JJR
cord-023439-r04y1j22	562	36	doses	dose	NNS
cord-023439-r04y1j22	562	37	of	of	IN
cord-023439-r04y1j22	562	38	immunogen	immunogen	NN
cord-023439-r04y1j22	562	39	(	(	-LRB-
cord-023439-r04y1j22	562	40	0.01	0.01	CD
cord-023439-r04y1j22	562	41	mg	mg	NN
cord-023439-r04y1j22	562	42	per	per	IN
cord-023439-r04y1j22	562	43	doses	dose	NNS
cord-023439-r04y1j22	562	44	)	)	-RRB-
cord-023439-r04y1j22	562	45	.	.	.
cord-023439-r04y1j22	563	1	Moreover	moreover	RB
cord-023439-r04y1j22	563	2	,	,	,
cord-023439-r04y1j22	563	3	Ab1	ab1	NN
cord-023439-r04y1j22	563	4	and	and	CC
cord-023439-r04y1j22	563	5	Ab2	ab2	NN
cord-023439-r04y1j22	563	6	antibodies	antibody	NNS
cord-023439-r04y1j22	563	7	were	be	VBD
cord-023439-r04y1j22	563	8	detected	detect	VBN
cord-023439-r04y1j22	563	9	in	in	IN
cord-023439-r04y1j22	563	10	the	the	DT
cord-023439-r04y1j22	563	11	sera	sera	NNP
cord-023439-r04y1j22	563	12	of	of	IN
cord-023439-r04y1j22	563	13	Lactobacillus	Lactobacillus	NNP
cord-023439-r04y1j22	563	14	-	-	HYPH
cord-023439-r04y1j22	563	15	hyperimmunized	hyperimmunize	VBN
cord-023439-r04y1j22	563	16	mice	mouse	NNS
cord-023439-r04y1j22	563	17	.	.	.
cord-023439-r04y1j22	564	1	In	in	IN
cord-023439-r04y1j22	564	2	this	this	DT
cord-023439-r04y1j22	564	3	study	study	NN
cord-023439-r04y1j22	564	4	,	,	,
cord-023439-r04y1j22	564	5	we	-PRON-	PRP
cord-023439-r04y1j22	564	6	have	have	VBP
cord-023439-r04y1j22	564	7	shown	show	VBN
cord-023439-r04y1j22	564	8	the	the	DT
cord-023439-r04y1j22	564	9	idiotypic	idiotypic	NNP
cord-023439-r04y1j22	564	10	network	network	NN
cord-023439-r04y1j22	564	11	interactions	interaction	NNS
cord-023439-r04y1j22	564	12	in	in	IN
cord-023439-r04y1j22	564	13	mice	mouse	NNS
cord-023439-r04y1j22	564	14	immunized	immunize	VBN
cord-023439-r04y1j22	564	15	with	with	IN
cord-023439-r04y1j22	564	16	bacteria	bacteria	NNS
cord-023439-r04y1j22	564	17	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	564	18	acidophilus	acidophilus	NN
cord-023439-r04y1j22	564	19	.	.	.
cord-023439-r04y1j22	565	1	The	the	DT
cord-023439-r04y1j22	565	2	normal	normal	JJ
cord-023439-r04y1j22	565	3	gastrointestinal	gastrointestinal	JJ
cord-023439-r04y1j22	565	4	flora	flora	NNS
cord-023439-r04y1j22	565	5	is	be	VBZ
cord-023439-r04y1j22	565	6	crucial	crucial	JJ
cord-023439-r04y1j22	565	7	for	for	IN
cord-023439-r04y1j22	565	8	the	the	DT
cord-023439-r04y1j22	565	9	maturation	maturation	NN
cord-023439-r04y1j22	565	10	of	of	IN
cord-023439-r04y1j22	565	11	the	the	DT
cord-023439-r04y1j22	565	12	acquired	acquire	VBN
cord-023439-r04y1j22	565	13	immunity	immunity	NN
cord-023439-r04y1j22	565	14	via	via	IN
cord-023439-r04y1j22	565	15	effects	effect	NNS
cord-023439-r04y1j22	565	16	on	on	IN
cord-023439-r04y1j22	565	17	antigenpresenting	antigenpresente	VBG
cord-023439-r04y1j22	565	18	cells	cell	NNS
cord-023439-r04y1j22	565	19	(	(	-LRB-
cord-023439-r04y1j22	565	20	APCs	apc	NNS
cord-023439-r04y1j22	565	21	)	)	-RRB-
cord-023439-r04y1j22	565	22	.	.	.
cord-023439-r04y1j22	566	1	Here	here	RB
cord-023439-r04y1j22	566	2	,	,	,
cord-023439-r04y1j22	566	3	we	-PRON-	PRP
cord-023439-r04y1j22	566	4	have	have	VBP
cord-023439-r04y1j22	566	5	investigated	investigate	VBN
cord-023439-r04y1j22	566	6	how	how	WRB
cord-023439-r04y1j22	566	7	two	two	CD
cord-023439-r04y1j22	566	8	types	type	NNS
cord-023439-r04y1j22	566	9	of	of	IN
cord-023439-r04y1j22	566	10	APCs	apc	NNS
cord-023439-r04y1j22	566	11	,	,	,
cord-023439-r04y1j22	566	12	monocytes	monocyte	NNS
cord-023439-r04y1j22	566	13	and	and	CC
cord-023439-r04y1j22	566	14	dendritic	dendritic	JJ
cord-023439-r04y1j22	566	15	cells	cell	NNS
cord-023439-r04y1j22	566	16	(	(	-LRB-
cord-023439-r04y1j22	566	17	DCs	DCs	NNP
cord-023439-r04y1j22	566	18	)	)	-RRB-
cord-023439-r04y1j22	566	19	,	,	,
cord-023439-r04y1j22	566	20	react	react	VBP
cord-023439-r04y1j22	566	21	to	to	IN
cord-023439-r04y1j22	566	22	different	different	JJ
cord-023439-r04y1j22	566	23	bacterial	bacterial	JJ
cord-023439-r04y1j22	566	24	strains	strain	NNS
cord-023439-r04y1j22	566	25	typical	typical	JJ
cord-023439-r04y1j22	566	26	of	of	IN
cord-023439-r04y1j22	566	27	the	the	DT
cord-023439-r04y1j22	566	28	commensal	commensal	JJ
cord-023439-r04y1j22	566	29	intestinal	intestinal	JJ
cord-023439-r04y1j22	566	30	flora	flora	NNS
cord-023439-r04y1j22	566	31	.	.	.
cord-023439-r04y1j22	567	1	Purified	purify	VBN
cord-023439-r04y1j22	567	2	monocytes	monocyte	NNS
cord-023439-r04y1j22	567	3	and	and	CC
cord-023439-r04y1j22	567	4	monocyte	monocyte	NN
cord-023439-r04y1j22	567	5	-	-	HYPH
cord-023439-r04y1j22	567	6	derived	derive	VBN
cord-023439-r04y1j22	567	7	DCs	dc	NNS
cord-023439-r04y1j22	567	8	were	be	VBD
cord-023439-r04y1j22	567	9	stimulated	stimulate	VBN
cord-023439-r04y1j22	567	10	with	with	IN
cord-023439-r04y1j22	567	11	UV	uv	NN
cord-023439-r04y1j22	567	12	-	-	HYPH
cord-023439-r04y1j22	567	13	inactivated	inactivate	VBN
cord-023439-r04y1j22	567	14	gram	gram	NN
cord-023439-r04y1j22	567	15	-	-	HYPH
cord-023439-r04y1j22	567	16	positive	positive	JJ
cord-023439-r04y1j22	567	17	(	(	-LRB-
cord-023439-r04y1j22	567	18	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	567	19	plantarum	plantarum	NNS
cord-023439-r04y1j22	567	20	and	and	CC
cord-023439-r04y1j22	567	21	Bifidobacterium	Bifidobacterium	NNP
cord-023439-r04y1j22	567	22	adolescentis	adolescentis	NNP
cord-023439-r04y1j22	567	23	)	)	-RRB-
cord-023439-r04y1j22	567	24	and	and	CC
cord-023439-r04y1j22	567	25	gram	gram	NN
cord-023439-r04y1j22	567	26	-	-	HYPH
cord-023439-r04y1j22	567	27	negative	negative	JJ
cord-023439-r04y1j22	567	28	(	(	-LRB-
cord-023439-r04y1j22	567	29	Escherichia	escherichia	NN
cord-023439-r04y1j22	567	30	coli	coli	NNS
cord-023439-r04y1j22	567	31	and	and	CC
cord-023439-r04y1j22	567	32	Veillonella	Veillonella	NNP
cord-023439-r04y1j22	567	33	parvula	parvula	NN
cord-023439-r04y1j22	567	34	)	)	-RRB-
cord-023439-r04y1j22	567	35	bacterial	bacterial	JJ
cord-023439-r04y1j22	567	36	strains	strain	NNS
cord-023439-r04y1j22	567	37	.	.	.
cord-023439-r04y1j22	568	1	Monocytes	monocyte	NNS
cord-023439-r04y1j22	568	2	produced	produce	VBD
cord-023439-r04y1j22	568	3	higher	high	JJR
cord-023439-r04y1j22	568	4	levels	level	NNS
cord-023439-r04y1j22	568	5	of	of	IN
cord-023439-r04y1j22	568	6	IL-12p70	IL-12p70	NNP
cord-023439-r04y1j22	568	7	and	and	CC
cord-023439-r04y1j22	568	8	TNF	TNF	NNP
cord-023439-r04y1j22	568	9	,	,	,
cord-023439-r04y1j22	568	10	as	as	IN
cord-023439-r04y1j22	568	11	detected	detect	VBN
cord-023439-r04y1j22	568	12	by	by	IN
cord-023439-r04y1j22	568	13	ELISA	ELISA	NNP
cord-023439-r04y1j22	568	14	,	,	,
cord-023439-r04y1j22	568	15	in	in	IN
cord-023439-r04y1j22	568	16	response	response	NN
cord-023439-r04y1j22	568	17	to	to	IN
cord-023439-r04y1j22	568	18	L.	L.	NNP
cord-023439-r04y1j22	568	19	plantarum	plantarum	NNS
cord-023439-r04y1j22	568	20	than	than	IN
cord-023439-r04y1j22	568	21	to	to	IN
cord-023439-r04y1j22	568	22	E.	E.	NNP
cord-023439-r04y1j22	568	23	coli	coli	NNS
cord-023439-r04y1j22	568	24	and	and	CC
cord-023439-r04y1j22	568	25	V.	V.	NNP
cord-023439-r04y1j22	568	26	parvula	parvula	NNP
cord-023439-r04y1j22	568	27	.	.	.
cord-023439-r04y1j22	569	1	In	in	IN
cord-023439-r04y1j22	569	2	contrast	contrast	NN
cord-023439-r04y1j22	569	3	,	,	,
cord-023439-r04y1j22	569	4	DCs	DCs	NNP
cord-023439-r04y1j22	569	5	secreted	secrete	VBD
cord-023439-r04y1j22	569	6	high	high	JJ
cord-023439-r04y1j22	569	7	amounts	amount	NNS
cord-023439-r04y1j22	569	8	of	of	IN
cord-023439-r04y1j22	569	9	IL-12p70	IL-12p70	NNP
cord-023439-r04y1j22	569	10	,	,	,
cord-023439-r04y1j22	569	11	TNF	TNF	NNP
cord-023439-r04y1j22	569	12	,	,	,
cord-023439-r04y1j22	569	13	IL-6	IL-6	NNP
cord-023439-r04y1j22	569	14	and	and	CC
cord-023439-r04y1j22	569	15	IL-10	IL-10	NNP
cord-023439-r04y1j22	569	16	in	in	IN
cord-023439-r04y1j22	569	17	response	response	NN
cord-023439-r04y1j22	569	18	to	to	IN
cord-023439-r04y1j22	569	19	E.	E.	NNP
cord-023439-r04y1j22	569	20	coli	coli	NNS
cord-023439-r04y1j22	569	21	and	and	CC
cord-023439-r04y1j22	569	22	V.	V.	NNP
cord-023439-r04y1j22	569	23	parvula	parvula	NN
cord-023439-r04y1j22	569	24	but	but	CC
cord-023439-r04y1j22	569	25	were	be	VBD
cord-023439-r04y1j22	569	26	practically	practically	RB
cord-023439-r04y1j22	569	27	unresponsive	unresponsive	JJ
cord-023439-r04y1j22	569	28	to	to	IN
cord-023439-r04y1j22	569	29	L.	L.	NNP
cord-023439-r04y1j22	569	30	plantarum	plantarum	NNS
cord-023439-r04y1j22	569	31	and	and	CC
cord-023439-r04y1j22	569	32	B.	B.	NNP
cord-023439-r04y1j22	569	33	adolescentis	adolescentis	NNP
cord-023439-r04y1j22	569	34	.	.	.
cord-023439-r04y1j22	570	1	The	the	DT
cord-023439-r04y1j22	570	2	lack	lack	NN
cord-023439-r04y1j22	570	3	of	of	IN
cord-023439-r04y1j22	570	4	response	response	NN
cord-023439-r04y1j22	570	5	to	to	IN
cord-023439-r04y1j22	570	6	the	the	DT
cord-023439-r04y1j22	570	7	gram	gram	NN
cord-023439-r04y1j22	570	8	-	-	HYPH
cord-023439-r04y1j22	570	9	positive	positive	JJ
cord-023439-r04y1j22	570	10	strains	strain	NNS
cord-023439-r04y1j22	570	11	correlated	correlate	VBN
cord-023439-r04y1j22	570	12	with	with	IN
cord-023439-r04y1j22	570	13	a	a	DT
cord-023439-r04y1j22	570	14	lower	low	JJR
cord-023439-r04y1j22	570	15	surface	surface	NN
cord-023439-r04y1j22	570	16	expression	expression	NN
cord-023439-r04y1j22	570	17	of	of	IN
cord-023439-r04y1j22	570	18	Toll	Toll	NNP
cord-023439-r04y1j22	570	19	-	-	HYPH
cord-023439-r04y1j22	570	20	like	like	JJ
cord-023439-r04y1j22	570	21	reseptor	reseptor	NNP
cord-023439-r04y1j22	570	22	2	2	CD
cord-023439-r04y1j22	570	23	(	(	-LRB-
cord-023439-r04y1j22	570	24	TLR2	TLR2	NNP
cord-023439-r04y1j22	570	25	)	)	-RRB-
cord-023439-r04y1j22	570	26	on	on	IN
cord-023439-r04y1j22	570	27	DCs	dc	NNS
cord-023439-r04y1j22	570	28	compared	compare	VBN
cord-023439-r04y1j22	570	29	to	to	IN
cord-023439-r04y1j22	570	30	monocytes	monocyte	NNS
cord-023439-r04y1j22	570	31	.	.	.
cord-023439-r04y1j22	571	1	The	the	DT
cord-023439-r04y1j22	571	2	surface	surface	NN
cord-023439-r04y1j22	571	3	expression	expression	NN
cord-023439-r04y1j22	571	4	of	of	IN
cord-023439-r04y1j22	571	5	TLR4	TLR4	NNP
cord-023439-r04y1j22	571	6	on	on	IN
cord-023439-r04y1j22	571	7	DCs	dc	NNS
cord-023439-r04y1j22	571	8	was	be	VBD
cord-023439-r04y1j22	571	9	undetectable	undetectable	JJ
cord-023439-r04y1j22	571	10	when	when	WRB
cord-023439-r04y1j22	571	11	analysed	analyse	VBN
cord-023439-r04y1j22	571	12	by	by	IN
cord-023439-r04y1j22	571	13	flow	flow	NN
cord-023439-r04y1j22	571	14	cytometry	cytometry	NN
cord-023439-r04y1j22	571	15	,	,	,
cord-023439-r04y1j22	571	16	but	but	CC
cord-023439-r04y1j22	571	17	blocking	block	VBG
cord-023439-r04y1j22	571	18	this	this	DT
cord-023439-r04y1j22	571	19	receptor	receptor	NN
cord-023439-r04y1j22	571	20	decreased	decrease	VBD
cord-023439-r04y1j22	571	21	the	the	DT
cord-023439-r04y1j22	571	22	TNF	TNF	NNP
cord-023439-r04y1j22	571	23	production	production	NN
cord-023439-r04y1j22	571	24	in	in	IN
cord-023439-r04y1j22	571	25	response	response	NN
cord-023439-r04y1j22	571	26	to	to	IN
cord-023439-r04y1j22	571	27	V.	V.	NNP
cord-023439-r04y1j22	571	28	parvula	parvula	NNP
cord-023439-r04y1j22	571	29	,	,	,
cord-023439-r04y1j22	571	30	indicating	indicate	VBG
cord-023439-r04y1j22	571	31	that	that	IN
cord-023439-r04y1j22	571	32	low	low	JJ
cord-023439-r04y1j22	571	33	TLR4	tlr4	CD
cord-023439-r04y1j22	571	34	expression	expression	NN
cord-023439-r04y1j22	571	35	on	on	IN
cord-023439-r04y1j22	571	36	DCs	DCs	NNP
cord-023439-r04y1j22	571	37	is	be	VBZ
cord-023439-r04y1j22	571	38	sufficient	sufficient	JJ
cord-023439-r04y1j22	571	39	to	to	TO
cord-023439-r04y1j22	571	40	mount	mount	VB
cord-023439-r04y1j22	571	41	an	an	DT
cord-023439-r04y1j22	571	42	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	571	43	response	response	NN
cord-023439-r04y1j22	571	44	to	to	IN
cord-023439-r04y1j22	571	45	gram	gram	JJ
cord-023439-r04y1j22	571	46	-	-	HYPH
cord-023439-r04y1j22	571	47	negative	negative	JJ
cord-023439-r04y1j22	571	48	bacteria	bacteria	NNS
cord-023439-r04y1j22	571	49	.	.	.
cord-023439-r04y1j22	572	1	IFN	IFN	NNP
cord-023439-r04y1j22	572	2	-	-	HYPH
cord-023439-r04y1j22	572	3	g	g	NNP
cord-023439-r04y1j22	572	4	increased	increase	VBD
cord-023439-r04y1j22	572	5	the	the	DT
cord-023439-r04y1j22	572	6	expression	expression	NN
cord-023439-r04y1j22	572	7	of	of	IN
cord-023439-r04y1j22	572	8	TLR4	TLR4	NNP
cord-023439-r04y1j22	572	9	on	on	IN
cord-023439-r04y1j22	572	10	DCs	dc	NNS
cord-023439-r04y1j22	572	11	and	and	CC
cord-023439-r04y1j22	572	12	also	also	RB
cord-023439-r04y1j22	572	13	potentiated	potentiate	VBD
cord-023439-r04y1j22	572	14	the	the	DT
cord-023439-r04y1j22	572	15	cytokine	cytokine	NN
cord-023439-r04y1j22	572	16	response	response	NN
cord-023439-r04y1j22	572	17	to	to	IN
cord-023439-r04y1j22	572	18	gram	gram	JJ
cord-023439-r04y1j22	572	19	-	-	HYPH
cord-023439-r04y1j22	572	20	negative	negative	JJ
cord-023439-r04y1j22	572	21	bacteria	bacteria	NNS
cord-023439-r04y1j22	572	22	.	.	.
cord-023439-r04y1j22	573	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	573	2	results	result	NNS
cord-023439-r04y1j22	573	3	indicate	indicate	VBP
cord-023439-r04y1j22	573	4	that	that	IN
cord-023439-r04y1j22	573	5	,	,	,
cord-023439-r04y1j22	573	6	when	when	WRB
cord-023439-r04y1j22	573	7	monocytes	monocyte	NNS
cord-023439-r04y1j22	573	8	differentiate	differentiate	VBP
cord-023439-r04y1j22	573	9	into	into	IN
cord-023439-r04y1j22	573	10	DCs	dc	NNS
cord-023439-r04y1j22	573	11	,	,	,
cord-023439-r04y1j22	573	12	their	-PRON-	PRP$
cord-023439-r04y1j22	573	13	ability	ability	NN
cord-023439-r04y1j22	573	14	to	to	TO
cord-023439-r04y1j22	573	15	respond	respond	VB
cord-023439-r04y1j22	573	16	to	to	IN
cord-023439-r04y1j22	573	17	different	different	JJ
cord-023439-r04y1j22	573	18	commensal	commensal	JJ
cord-023439-r04y1j22	573	19	bacteria	bacteria	NNS
cord-023439-r04y1j22	573	20	dramatically	dramatically	RB
cord-023439-r04y1j22	573	21	changes	change	NNS
cord-023439-r04y1j22	573	22	,	,	,
cord-023439-r04y1j22	573	23	thereby	thereby	RB
cord-023439-r04y1j22	573	24	becoming	become	VBG
cord-023439-r04y1j22	573	25	unresponsive	unresponsive	JJ
cord-023439-r04y1j22	573	26	to	to	IN
cord-023439-r04y1j22	573	27	probiotic	probiotic	JJ
cord-023439-r04y1j22	573	28	gram	gram	NN
cord-023439-r04y1j22	573	29	-	-	HYPH
cord-023439-r04y1j22	573	30	positive	positive	JJ
cord-023439-r04y1j22	573	31	bacteria	bacteria	NNS
cord-023439-r04y1j22	573	32	.	.	.
cord-023439-r04y1j22	574	1	These	these	DT
cord-023439-r04y1j22	574	2	results	result	NNS
cord-023439-r04y1j22	574	3	may	may	MD
cord-023439-r04y1j22	574	4	have	have	VB
cord-023439-r04y1j22	574	5	important	important	JJ
cord-023439-r04y1j22	574	6	implications	implication	NNS
cord-023439-r04y1j22	574	7	for	for	IN
cord-023439-r04y1j22	574	8	the	the	DT
cord-023439-r04y1j22	574	9	capacity	capacity	NN
cord-023439-r04y1j22	574	10	of	of	IN
cord-023439-r04y1j22	574	11	different	different	JJ
cord-023439-r04y1j22	574	12	groups	group	NNS
cord-023439-r04y1j22	574	13	of	of	IN
cord-023439-r04y1j22	574	14	commensal	commensal	JJ
cord-023439-r04y1j22	574	15	bacteria	bacteria	NNS
cord-023439-r04y1j22	574	16	to	to	TO
cord-023439-r04y1j22	574	17	regulate	regulate	VB
cord-023439-r04y1j22	574	18	mucosal	mucosal	JJ
cord-023439-r04y1j22	574	19	and	and	CC
cord-023439-r04y1j22	574	20	systemic	systemic	JJ
cord-023439-r04y1j22	574	21	immunity	immunity	NN
cord-023439-r04y1j22	574	22	.	.	.
cord-023439-r04y1j22	575	1	Probiotic	probiotic	JJ
cord-023439-r04y1j22	575	2	bacteria	bacteria	NNS
cord-023439-r04y1j22	575	3	,	,	,
cord-023439-r04y1j22	575	4	e.g.	e.g.	RB
cord-023439-r04y1j22	575	5	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	575	6	spp	spp	NNS
cord-023439-r04y1j22	575	7	.	.	.
cord-023439-r04y1j22	575	8	,	,	,
cord-023439-r04y1j22	575	9	may	may	MD
cord-023439-r04y1j22	575	10	improve	improve	VB
cord-023439-r04y1j22	575	11	diseases	disease	NNS
cord-023439-r04y1j22	575	12	such	such	JJ
cord-023439-r04y1j22	575	13	as	as	IN
cord-023439-r04y1j22	575	14	chronic	chronic	JJ
cord-023439-r04y1j22	575	15	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	575	16	bowel	bowel	NN
cord-023439-r04y1j22	575	17	disease	disease	NN
cord-023439-r04y1j22	575	18	.	.	.
cord-023439-r04y1j22	576	1	We	-PRON-	PRP
cord-023439-r04y1j22	576	2	examined	examine	VBD
cord-023439-r04y1j22	576	3	cytokine	cytokine	JJ
cord-023439-r04y1j22	576	4	production	production	NN
cord-023439-r04y1j22	576	5	and	and	CC
cord-023439-r04y1j22	576	6	phenotypic	phenotypic	JJ
cord-023439-r04y1j22	576	7	change	change	NN
cord-023439-r04y1j22	576	8	after	after	IN
cord-023439-r04y1j22	576	9	in	in	IN
cord-023439-r04y1j22	576	10	vitro	vitro	FW
cord-023439-r04y1j22	576	11	stimulation	stimulation	NN
cord-023439-r04y1j22	576	12	of	of	IN
cord-023439-r04y1j22	576	13	T	t	NN
cord-023439-r04y1j22	576	14	cells	cell	NNS
cord-023439-r04y1j22	576	15	from	from	IN
cord-023439-r04y1j22	576	16	healthy	healthy	JJ
cord-023439-r04y1j22	576	17	volunteers	volunteer	NNS
cord-023439-r04y1j22	576	18	using	use	VBG
cord-023439-r04y1j22	576	19	different	different	JJ
cord-023439-r04y1j22	576	20	probiotic	probiotic	JJ
cord-023439-r04y1j22	576	21	strains	strain	NNS
cord-023439-r04y1j22	576	22	.	.	.
cord-023439-r04y1j22	577	1	Methods	method	NNS
cord-023439-r04y1j22	577	2	:	:	:
cord-023439-r04y1j22	577	3	T	t	NN
cord-023439-r04y1j22	577	4	cells	cell	NNS
cord-023439-r04y1j22	577	5	were	be	VBD
cord-023439-r04y1j22	577	6	cultured	culture	VBN
cord-023439-r04y1j22	577	7	from	from	IN
cord-023439-r04y1j22	577	8	colonic	colonic	JJ
cord-023439-r04y1j22	577	9	biopsies	biopsy	NNS
cord-023439-r04y1j22	577	10	from	from	IN
cord-023439-r04y1j22	577	11	eight	eight	CD
cord-023439-r04y1j22	577	12	healthy	healthy	JJ
cord-023439-r04y1j22	577	13	volunteers	volunteer	NNS
cord-023439-r04y1j22	577	14	(	(	-LRB-
cord-023439-r04y1j22	577	15	Agnholt	Agnholt	NNP
cord-023439-r04y1j22	577	16	and	and	CC
cord-023439-r04y1j22	577	17	Kaltoft	Kaltoft	NNP
cord-023439-r04y1j22	577	18	,	,	,
cord-023439-r04y1j22	577	19	Exp	Exp	NNP
cord-023439-r04y1j22	577	20	Clin	Clin	NNP
cord-023439-r04y1j22	577	21	Immunogenet	Immunogenet	NNP
cord-023439-r04y1j22	577	22	2001	2001	CD
cord-023439-r04y1j22	577	23	;	;	:
cord-023439-r04y1j22	577	24	18:213	18:213	CD
cord-023439-r04y1j22	577	25	-	-	SYM
cord-023439-r04y1j22	577	26	25	25	CD
cord-023439-r04y1j22	577	27	)	)	-RRB-
cord-023439-r04y1j22	577	28	,	,	,
cord-023439-r04y1j22	577	29	and	and	CC
cord-023439-r04y1j22	577	30	dendritic	dendritic	JJ
cord-023439-r04y1j22	577	31	cells	cell	NNS
cord-023439-r04y1j22	577	32	were	be	VBD
cord-023439-r04y1j22	577	33	matured	mature	VBN
cord-023439-r04y1j22	577	34	from	from	IN
cord-023439-r04y1j22	577	35	their	-PRON-	PRP$
cord-023439-r04y1j22	577	36	peripheral	peripheral	JJ
cord-023439-r04y1j22	577	37	blood	blood	NN
cord-023439-r04y1j22	577	38	mononuclear	mononuclear	NN
cord-023439-r04y1j22	577	39	cells	cell	NNS
cord-023439-r04y1j22	577	40	.	.	.
cord-023439-r04y1j22	578	1	T	t	NN
cord-023439-r04y1j22	578	2	-	-	HYPH
cord-023439-r04y1j22	578	3	cell	cell	NN
cord-023439-r04y1j22	578	4	cultures	culture	NNS
cord-023439-r04y1j22	578	5	were	be	VBD
cord-023439-r04y1j22	578	6	stimulated	stimulate	VBN
cord-023439-r04y1j22	578	7	with	with	IN
cord-023439-r04y1j22	578	8	autologous	autologous	JJ
cord-023439-r04y1j22	578	9	bacterial	bacterial	JJ
cord-023439-r04y1j22	578	10	sonicate	sonicate	NN
cord-023439-r04y1j22	578	11	or	or	CC
cord-023439-r04y1j22	578	12	strains	strain	NNS
cord-023439-r04y1j22	578	13	of	of	IN
cord-023439-r04y1j22	578	14	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	578	15	spp	spp	NNS
cord-023439-r04y1j22	578	16	.	.	.
cord-023439-r04y1j22	579	1	,	,	,
cord-023439-r04y1j22	579	2	with	with	IN
cord-023439-r04y1j22	579	3	and	and	CC
cord-023439-r04y1j22	579	4	without	without	IN
cord-023439-r04y1j22	579	5	the	the	DT
cord-023439-r04y1j22	579	6	addition	addition	NN
cord-023439-r04y1j22	579	7	of	of	IN
cord-023439-r04y1j22	579	8	dendritic	dendritic	JJ
cord-023439-r04y1j22	579	9	cells	cell	NNS
cord-023439-r04y1j22	579	10	.	.	.
cord-023439-r04y1j22	580	1	Cytokine	cytokine	NN
cord-023439-r04y1j22	580	2	levels	level	NNS
cord-023439-r04y1j22	580	3	(	(	-LRB-
cord-023439-r04y1j22	580	4	TNF	TNF	NNP
cord-023439-r04y1j22	580	5	-	-	HYPH
cord-023439-r04y1j22	580	6	a	a	NNP
cord-023439-r04y1j22	580	7	,	,	,
cord-023439-r04y1j22	580	8	IFN	IFN	NNP
cord-023439-r04y1j22	580	9	-	-	HYPH
cord-023439-r04y1j22	580	10	g	g	NNP
cord-023439-r04y1j22	580	11	,	,	,
cord-023439-r04y1j22	580	12	IL-10	IL-10	NNP
cord-023439-r04y1j22	580	13	and	and	CC
cord-023439-r04y1j22	580	14	GM	GM	NNP
cord-023439-r04y1j22	580	15	-	-	HYPH
cord-023439-r04y1j22	580	16	CSF	CSF	NNP
cord-023439-r04y1j22	580	17	)	)	-RRB-
cord-023439-r04y1j22	580	18	and	and	CC
cord-023439-r04y1j22	580	19	phenotype	phenotype	NN
cord-023439-r04y1j22	580	20	(	(	-LRB-
cord-023439-r04y1j22	580	21	CD3	CD3	NNP
cord-023439-r04y1j22	580	22	,	,	,
cord-023439-r04y1j22	580	23	CD4	CD4	NNP
cord-023439-r04y1j22	580	24	,	,	,
cord-023439-r04y1j22	580	25	CD25	CD25	NNP
cord-023439-r04y1j22	580	26	and	and	CC
cord-023439-r04y1j22	580	27	CD69	CD69	NNP
cord-023439-r04y1j22	580	28	)	)	-RRB-
cord-023439-r04y1j22	580	29	were	be	VBD
cord-023439-r04y1j22	580	30	measured	measure	VBN
cord-023439-r04y1j22	580	31	on	on	IN
cord-023439-r04y1j22	580	32	day	day	NN
cord-023439-r04y1j22	580	33	4	4	CD
cord-023439-r04y1j22	580	34	.	.	.
cord-023439-r04y1j22	581	1	Results	result	NNS
cord-023439-r04y1j22	581	2	:	:	:
cord-023439-r04y1j22	582	1	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	582	2	spp	spp	NNS
cord-023439-r04y1j22	582	3	.	.	.
cord-023439-r04y1j22	583	1	induced	induce	VBN
cord-023439-r04y1j22	583	2	higher	high	JJR
cord-023439-r04y1j22	583	3	productions	production	NNS
cord-023439-r04y1j22	583	4	of	of	IN
cord-023439-r04y1j22	583	5	TNF	TNF	NNP
cord-023439-r04y1j22	583	6	-	-	:
cord-023439-r04y1j22	583	7	a	a	NNP
cord-023439-r04y1j22	583	8	and	and	CC
cord-023439-r04y1j22	583	9	IL-10	IL-10	NNP
cord-023439-r04y1j22	583	10	than	than	IN
cord-023439-r04y1j22	583	11	did	do	VBD
cord-023439-r04y1j22	583	12	autologous	autologous	JJ
cord-023439-r04y1j22	583	13	bacteria	bacteria	NNS
cord-023439-r04y1j22	583	14	.	.	.
cord-023439-r04y1j22	584	1	In	in	IN
cord-023439-r04y1j22	584	2	presence	presence	NN
cord-023439-r04y1j22	584	3	of	of	IN
cord-023439-r04y1j22	584	4	dendritic	dendritic	JJ
cord-023439-r04y1j22	584	5	cells	cell	NNS
cord-023439-r04y1j22	584	6	,	,	,
cord-023439-r04y1j22	584	7	the	the	DT
cord-023439-r04y1j22	584	8	production	production	NN
cord-023439-r04y1j22	584	9	of	of	IN
cord-023439-r04y1j22	584	10	all	all	DT
cord-023439-r04y1j22	584	11	cytokines	cytokine	NNS
cord-023439-r04y1j22	584	12	increased	increase	VBD
cord-023439-r04y1j22	584	13	.	.	.
cord-023439-r04y1j22	585	1	However	however	RB
cord-023439-r04y1j22	585	2	,	,	,
cord-023439-r04y1j22	585	3	the	the	DT
cord-023439-r04y1j22	585	4	increases	increase	NNS
cord-023439-r04y1j22	585	5	of	of	IN
cord-023439-r04y1j22	585	6	IFN	IFN	NNP
cord-023439-r04y1j22	585	7	-	-	HYPH
cord-023439-r04y1j22	585	8	g	g	NNP
cord-023439-r04y1j22	585	9	and	and	CC
cord-023439-r04y1j22	585	10	TNF	TNF	NNP
cord-023439-r04y1j22	585	11	-	-	,
cord-023439-r04y1j22	585	12	a	a	NNP
cord-023439-r04y1j22	585	13	were	be	VBD
cord-023439-r04y1j22	585	14	more	more	RBR
cord-023439-r04y1j22	585	15	pronounced	pronounced	JJ
cord-023439-r04y1j22	585	16	in	in	IN
cord-023439-r04y1j22	585	17	wells	well	NNS
cord-023439-r04y1j22	585	18	with	with	IN
cord-023439-r04y1j22	585	19	autologous	autologous	JJ
cord-023439-r04y1j22	585	20	bacteria	bacteria	NNS
cord-023439-r04y1j22	585	21	than	than	IN
cord-023439-r04y1j22	585	22	in	in	IN
cord-023439-r04y1j22	585	23	wells	well	NNS
cord-023439-r04y1j22	585	24	with	with	IN
cord-023439-r04y1j22	585	25	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	585	26	spp	spp	NNS
cord-023439-r04y1j22	585	27	.	.	.
cord-023439-r04y1j22	586	1	The	the	DT
cord-023439-r04y1j22	586	2	addition	addition	NN
cord-023439-r04y1j22	586	3	of	of	IN
cord-023439-r04y1j22	586	4	dendritic	dendritic	JJ
cord-023439-r04y1j22	586	5	cells	cell	NNS
cord-023439-r04y1j22	586	6	upregulated	upregulate	VBD
cord-023439-r04y1j22	586	7	CD25	cd25	JJ
cord-023439-r04y1j22	586	8	expression	expression	NN
cord-023439-r04y1j22	586	9	without	without	IN
cord-023439-r04y1j22	586	10	simultaneous	simultaneous	JJ
cord-023439-r04y1j22	586	11	upregulation	upregulation	NN
cord-023439-r04y1j22	586	12	of	of	IN
cord-023439-r04y1j22	586	13	CD69	CD69	NNP
cord-023439-r04y1j22	586	14	.	.	.
cord-023439-r04y1j22	587	1	The	the	DT
cord-023439-r04y1j22	587	2	upregulation	upregulation	NN
cord-023439-r04y1j22	587	3	was	be	VBD
cord-023439-r04y1j22	587	4	pronounced	pronounce	VBN
cord-023439-r04y1j22	587	5	after	after	IN
cord-023439-r04y1j22	587	6	stimulation	stimulation	NN
cord-023439-r04y1j22	587	7	with	with	IN
cord-023439-r04y1j22	587	8	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	587	9	rhamnosus	rhamnosus	NN
cord-023439-r04y1j22	587	10	GG	GG	NNP
cord-023439-r04y1j22	587	11	compared	compare	VBN
cord-023439-r04y1j22	587	12	with	with	IN
cord-023439-r04y1j22	587	13	autologous	autologous	JJ
cord-023439-r04y1j22	587	14	bacteria	bacteria	NNS
cord-023439-r04y1j22	587	15	and	and	CC
cord-023439-r04y1j22	587	16	other	other	JJ
cord-023439-r04y1j22	587	17	lactobacilli	lactobacillus	NNS
cord-023439-r04y1j22	587	18	.	.	.
cord-023439-r04y1j22	588	1	Discussion	discussion	NN
cord-023439-r04y1j22	588	2	:	:	:
cord-023439-r04y1j22	589	1	In	in	IN
cord-023439-r04y1j22	589	2	presence	presence	NN
cord-023439-r04y1j22	589	3	of	of	IN
cord-023439-r04y1j22	589	4	dendritic	dendritic	JJ
cord-023439-r04y1j22	589	5	cells	cell	NNS
cord-023439-r04y1j22	589	6	,	,	,
cord-023439-r04y1j22	589	7	autologous	autologous	JJ
cord-023439-r04y1j22	589	8	bacteria	bacteria	NNS
cord-023439-r04y1j22	589	9	induced	induce	VBD
cord-023439-r04y1j22	589	10	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	589	11	cytokines	cytokine	NNS
cord-023439-r04y1j22	589	12	,	,	,
cord-023439-r04y1j22	589	13	while	while	IN
cord-023439-r04y1j22	589	14	probiotics	probiotic	NNS
cord-023439-r04y1j22	589	15	mainly	mainly	RB
cord-023439-r04y1j22	589	16	induced	induce	VBN
cord-023439-r04y1j22	589	17	regulatory	regulatory	JJ
cord-023439-r04y1j22	589	18	cytokines	cytokine	NNS
cord-023439-r04y1j22	589	19	.	.	.
cord-023439-r04y1j22	590	1	Lactobacillus	lactobacillus	NN
cord-023439-r04y1j22	590	2	rhamnosus	rhamnosus	NN
cord-023439-r04y1j22	590	3	GG	GG	NNP
cord-023439-r04y1j22	590	4	induced	induce	VBD
cord-023439-r04y1j22	590	5	a	a	DT
cord-023439-r04y1j22	590	6	regulatory	regulatory	JJ
cord-023439-r04y1j22	590	7	phenotype	phenotype	NN
cord-023439-r04y1j22	590	8	(	(	-LRB-
cord-023439-r04y1j22	590	9	cd25	cd25	NN
cord-023439-r04y1j22	590	10	þ	þ	NNP
cord-023439-r04y1j22	590	11	)	)	-RRB-
cord-023439-r04y1j22	590	12	,	,	,
cord-023439-r04y1j22	590	13	in	in	IN
cord-023439-r04y1j22	590	14	part	part	NN
cord-023439-r04y1j22	590	15	mediated	mediate	VBN
cord-023439-r04y1j22	590	16	by	by	IN
cord-023439-r04y1j22	590	17	dendritic	dendritic	JJ
cord-023439-r04y1j22	590	18	cells	cell	NNS
cord-023439-r04y1j22	590	19	.	.	.
cord-023439-r04y1j22	591	1	Future	future	JJ
cord-023439-r04y1j22	591	2	studies	study	NNS
cord-023439-r04y1j22	591	3	will	will	MD
cord-023439-r04y1j22	591	4	address	address	VB
cord-023439-r04y1j22	591	5	whether	whether	IN
cord-023439-r04y1j22	591	6	this	this	DT
cord-023439-r04y1j22	591	7	shift	shift	NN
cord-023439-r04y1j22	591	8	to	to	IN
cord-023439-r04y1j22	591	9	a	a	DT
cord-023439-r04y1j22	591	10	CD25	CD25	NNP
cord-023439-r04y1j22	591	11	þ	þ	NNP
cord-023439-r04y1j22	591	12	phenotype	phenotype	NN
cord-023439-r04y1j22	591	13	represents	represent	VBZ
cord-023439-r04y1j22	591	14	a	a	DT
cord-023439-r04y1j22	591	15	differentiation	differentiation	NN
cord-023439-r04y1j22	591	16	into	into	IN
cord-023439-r04y1j22	591	17	competent	competent	JJ
cord-023439-r04y1j22	591	18	regulatory	regulatory	JJ
cord-023439-r04y1j22	591	19	T	t	NN
cord-023439-r04y1j22	591	20	cells	cell	NNS
cord-023439-r04y1j22	591	21	.	.	.
cord-023439-r04y1j22	592	1	In	in	IN
cord-023439-r04y1j22	592	2	a	a	DT
cord-023439-r04y1j22	592	3	clinical	clinical	JJ
cord-023439-r04y1j22	592	4	context	context	NN
cord-023439-r04y1j22	592	5	,	,	,
cord-023439-r04y1j22	592	6	such	such	JJ
cord-023439-r04y1j22	592	7	cells	cell	NNS
cord-023439-r04y1j22	592	8	might	may	MD
cord-023439-r04y1j22	592	9	be	be	VB
cord-023439-r04y1j22	592	10	used	use	VBN
cord-023439-r04y1j22	592	11	for	for	IN
cord-023439-r04y1j22	592	12	treatment	treatment	NN
cord-023439-r04y1j22	592	13	of	of	IN
cord-023439-r04y1j22	592	14	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	592	15	diseases	disease	NNS
cord-023439-r04y1j22	592	16	.	.	.
cord-023439-r04y1j22	593	1	Protein	protein	NN
cord-023439-r04y1j22	593	2	microarrays	microarray	NNS
cord-023439-r04y1j22	593	3	will	will	MD
cord-023439-r04y1j22	593	4	play	play	VB
cord-023439-r04y1j22	593	5	a	a	DT
cord-023439-r04y1j22	593	6	key	key	JJ
cord-023439-r04y1j22	593	7	role	role	NN
cord-023439-r04y1j22	593	8	in	in	IN
cord-023439-r04y1j22	593	9	the	the	DT
cord-023439-r04y1j22	593	10	postgenomic	postgenomic	NN
cord-023439-r04y1j22	593	11	era	era	NN
cord-023439-r04y1j22	593	12	and	and	CC
cord-023439-r04y1j22	593	13	offer	offer	VB
cord-023439-r04y1j22	593	14	a	a	DT
cord-023439-r04y1j22	593	15	unique	unique	JJ
cord-023439-r04y1j22	593	16	possibility	possibility	NN
cord-023439-r04y1j22	593	17	to	to	TO
cord-023439-r04y1j22	593	18	perform	perform	VB
cord-023439-r04y1j22	593	19	highthroughput	highthroughput	NN
cord-023439-r04y1j22	593	20	global	global	JJ
cord-023439-r04y1j22	593	21	proteome	proteome	NN
cord-023439-r04y1j22	593	22	analysis	analysis	NN
cord-023439-r04y1j22	593	23	.	.	.
cord-023439-r04y1j22	594	1	A	a	DT
cord-023439-r04y1j22	594	2	chip	chip	NN
cord-023439-r04y1j22	594	3	can	can	MD
cord-023439-r04y1j22	594	4	be	be	VB
cord-023439-r04y1j22	594	5	printed	print	VBN
cord-023439-r04y1j22	594	6	with	with	IN
cord-023439-r04y1j22	594	7	thousands	thousand	NNS
cord-023439-r04y1j22	594	8	of	of	IN
cord-023439-r04y1j22	594	9	protein	protein	NN
cord-023439-r04y1j22	594	10	probes	probe	NNS
cord-023439-r04y1j22	594	11	(	(	-LRB-
cord-023439-r04y1j22	594	12	e.g.	e.g.	IN
cord-023439-r04y1j22	594	13	antibodies	antibody	NNS
cord-023439-r04y1j22	594	14	)	)	-RRB-
cord-023439-r04y1j22	594	15	,	,	,
cord-023439-r04y1j22	594	16	the	the	DT
cord-023439-r04y1j22	594	17	biological	biological	JJ
cord-023439-r04y1j22	594	18	sample	sample	NN
cord-023439-r04y1j22	594	19	added	add	VBD
cord-023439-r04y1j22	594	20	(	(	-LRB-
cord-023439-r04y1j22	594	21	e.g.	e.g.	RB
cord-023439-r04y1j22	594	22	a	a	DT
cord-023439-r04y1j22	594	23	proteome	proteome	NN
cord-023439-r04y1j22	594	24	)	)	-RRB-
cord-023439-r04y1j22	594	25	and	and	CC
cord-023439-r04y1j22	594	26	any	any	DT
cord-023439-r04y1j22	594	27	binding	binding	NN
cord-023439-r04y1j22	594	28	detected	detect	VBN
cord-023439-r04y1j22	594	29	.	.	.
cord-023439-r04y1j22	595	1	We	-PRON-	PRP
cord-023439-r04y1j22	595	2	aim	aim	VBP
cord-023439-r04y1j22	595	3	to	to	TO
cord-023439-r04y1j22	595	4	develop	develop	VB
cord-023439-r04y1j22	595	5	protein	protein	NN
cord-023439-r04y1j22	595	6	microarrays	microarray	NNS
cord-023439-r04y1j22	595	7	based	base	VBN
cord-023439-r04y1j22	595	8	on	on	IN
cord-023439-r04y1j22	595	9	human	human	JJ
cord-023439-r04y1j22	595	10	recombinant	recombinant	JJ
cord-023439-r04y1j22	595	11	scFv	scfv	JJ
cord-023439-r04y1j22	595	12	antibody	antibody	NN
cord-023439-r04y1j22	595	13	fragments	fragment	NNS
cord-023439-r04y1j22	595	14	for	for	IN
cord-023439-r04y1j22	595	15	global	global	JJ
cord-023439-r04y1j22	595	16	proteome	proteome	NN
cord-023439-r04y1j22	595	17	analysis	analysis	NN
cord-023439-r04y1j22	595	18	.	.	.
cord-023439-r04y1j22	596	1	The	the	DT
cord-023439-r04y1j22	596	2	concept	concept	NN
cord-023439-r04y1j22	596	3	of	of	IN
cord-023439-r04y1j22	596	4	comparing	compare	VBG
cord-023439-r04y1j22	596	5	proteomic	proteomic	JJ
cord-023439-r04y1j22	596	6	maps	map	NNS
cord-023439-r04y1j22	596	7	of	of	IN
cord-023439-r04y1j22	596	8	healthy	healthy	JJ
cord-023439-r04y1j22	596	9	versus	versus	IN
cord-023439-r04y1j22	596	10	diseased	diseased	JJ
cord-023439-r04y1j22	596	11	samples	sample	NNS
cord-023439-r04y1j22	596	12	will	will	MD
cord-023439-r04y1j22	596	13	allow	allow	VB
cord-023439-r04y1j22	596	14	diseasespecific	diseasespecific	JJ
cord-023439-r04y1j22	596	15	proteins	protein	NNS
cord-023439-r04y1j22	596	16	to	to	TO
cord-023439-r04y1j22	596	17	be	be	VB
cord-023439-r04y1j22	596	18	detected	detect	VBN
cord-023439-r04y1j22	596	19	.	.	.
cord-023439-r04y1j22	597	1	In	in	IN
cord-023439-r04y1j22	597	2	fact	fact	NN
cord-023439-r04y1j22	597	3	,	,	,
cord-023439-r04y1j22	597	4	antibody	antibody	NN
cord-023439-r04y1j22	597	5	microarrays	microarray	NNS
cord-023439-r04y1j22	597	6	will	will	MD
cord-023439-r04y1j22	597	7	allow	allow	VB
cord-023439-r04y1j22	597	8	us	-PRON-	PRP
cord-023439-r04y1j22	597	9	to	to	TO
cord-023439-r04y1j22	597	10	perform	perform	VB
cord-023439-r04y1j22	597	11	comparative	comparative	JJ
cord-023439-r04y1j22	597	12	proteome	proteome	NN
cord-023439-r04y1j22	597	13	analysis	analysis	NN
cord-023439-r04y1j22	597	14	on	on	IN
cord-023439-r04y1j22	597	15	any	any	DT
cord-023439-r04y1j22	597	16	sample	sample	NN
cord-023439-r04y1j22	597	17	format	format	NN
cord-023439-r04y1j22	597	18	in	in	IN
cord-023439-r04y1j22	597	19	a	a	DT
cord-023439-r04y1j22	597	20	species	species	NN
cord-023439-r04y1j22	597	21	-	-	HYPH
cord-023439-r04y1j22	597	22	independent	independent	JJ
cord-023439-r04y1j22	597	23	manner	manner	NN
cord-023439-r04y1j22	597	24	,	,	,
cord-023439-r04y1j22	597	25	as	as	RB
cord-023439-r04y1j22	597	26	long	long	RB
cord-023439-r04y1j22	597	27	as	as	IN
cord-023439-r04y1j22	597	28	a	a	DT
cord-023439-r04y1j22	597	29	proteome	proteome	NN
cord-023439-r04y1j22	597	30	can	can	MD
cord-023439-r04y1j22	597	31	be	be	VB
cord-023439-r04y1j22	597	32	isolated	isolate	VBN
cord-023439-r04y1j22	597	33	.	.	.
cord-023439-r04y1j22	598	1	However	however	RB
cord-023439-r04y1j22	598	2	,	,	,
cord-023439-r04y1j22	598	3	the	the	DT
cord-023439-r04y1j22	598	4	complexity	complexity	NN
cord-023439-r04y1j22	598	5	of	of	IN
cord-023439-r04y1j22	598	6	proteomes	proteome	NNS
cord-023439-r04y1j22	598	7	,	,	,
cord-023439-r04y1j22	598	8	containing	contain	VBG
cord-023439-r04y1j22	598	9	several	several	JJ
cord-023439-r04y1j22	598	10	thousands	thousand	NNS
cord-023439-r04y1j22	598	11	of	of	IN
cord-023439-r04y1j22	598	12	different	different	JJ
cord-023439-r04y1j22	598	13	proteins	protein	NNS
cord-023439-r04y1j22	598	14	,	,	,
cord-023439-r04y1j22	598	15	is	be	VBZ
cord-023439-r04y1j22	598	16	a	a	DT
cord-023439-r04y1j22	598	17	problem	problem	NN
cord-023439-r04y1j22	598	18	.	.	.
cord-023439-r04y1j22	599	1	Here	here	RB
cord-023439-r04y1j22	599	2	,	,	,
cord-023439-r04y1j22	599	3	we	-PRON-	PRP
cord-023439-r04y1j22	599	4	have	have	VBP
cord-023439-r04y1j22	599	5	designed	design	VBN
cord-023439-r04y1j22	599	6	antibody	antibody	NN
cord-023439-r04y1j22	599	7	microarrays	microarray	NNS
cord-023439-r04y1j22	599	8	targeting	target	VBG
cord-023439-r04y1j22	599	9	the	the	DT
cord-023439-r04y1j22	599	10	water	water	NN
cord-023439-r04y1j22	599	11	-	-	HYPH
cord-023439-r04y1j22	599	12	soluble	soluble	JJ
cord-023439-r04y1j22	599	13	fraction	fraction	NN
cord-023439-r04y1j22	599	14	of	of	IN
cord-023439-r04y1j22	599	15	a	a	DT
cord-023439-r04y1j22	599	16	proteome	proteome	NN
cord-023439-r04y1j22	599	17	.	.	.
cord-023439-r04y1j22	600	1	To	to	IN
cord-023439-r04y1j22	600	2	this	this	DT
cord-023439-r04y1j22	600	3	end	end	NN
cord-023439-r04y1j22	600	4	,	,	,
cord-023439-r04y1j22	600	5	an	an	DT
cord-023439-r04y1j22	600	6	anticytokine	anticytokine	JJ
cord-023439-r04y1j22	600	7	antibody	antibody	NN
cord-023439-r04y1j22	600	8	array	array	NN
cord-023439-r04y1j22	600	9	was	be	VBD
cord-023439-r04y1j22	600	10	developed	develop	VBN
cord-023439-r04y1j22	600	11	and	and	CC
cord-023439-r04y1j22	600	12	human	human	JJ
cord-023439-r04y1j22	600	13	dendritic	dendritic	JJ
cord-023439-r04y1j22	600	14	cells	cell	NNS
cord-023439-r04y1j22	600	15	(	(	-LRB-
cord-023439-r04y1j22	600	16	AEactivation	AEactivation	NNP
cord-023439-r04y1j22	600	17	)	)	-RRB-
cord-023439-r04y1j22	600	18	was	be	VBD
cord-023439-r04y1j22	600	19	used	use	VBN
cord-023439-r04y1j22	600	20	as	as	IN
cord-023439-r04y1j22	600	21	model	model	NN
cord-023439-r04y1j22	600	22	system	system	NN
cord-023439-r04y1j22	600	23	.	.	.
cord-023439-r04y1j22	601	1	The	the	DT
cord-023439-r04y1j22	601	2	results	result	NNS
cord-023439-r04y1j22	601	3	showed	show	VBD
cord-023439-r04y1j22	601	4	that	that	IN
cord-023439-r04y1j22	601	5	our	-PRON-	PRP$
cord-023439-r04y1j22	601	6	antibody	antibody	NN
cord-023439-r04y1j22	601	7	microarrays	microarray	NNS
cord-023439-r04y1j22	601	8	could	could	MD
cord-023439-r04y1j22	601	9	be	be	VB
cord-023439-r04y1j22	601	10	used	use	VBN
cord-023439-r04y1j22	601	11	to	to	TO
cord-023439-r04y1j22	601	12	examine	examine	VB
cord-023439-r04y1j22	601	13	the	the	DT
cord-023439-r04y1j22	601	14	cytokine	cytokine	NN
cord-023439-r04y1j22	601	15	profile	profile	NN
cord-023439-r04y1j22	601	16	in	in	IN
cord-023439-r04y1j22	601	17	complex	complex	JJ
cord-023439-r04y1j22	601	18	samples	sample	NNS
cord-023439-r04y1j22	601	19	.	.	.
cord-023439-r04y1j22	602	1	Furthermore	furthermore	RB
cord-023439-r04y1j22	602	2	,	,	,
cord-023439-r04y1j22	602	3	we	-PRON-	PRP
cord-023439-r04y1j22	602	4	have	have	VBP
cord-023439-r04y1j22	602	5	taken	take	VBN
cord-023439-r04y1j22	602	6	the	the	DT
cord-023439-r04y1j22	602	7	first	first	JJ
cord-023439-r04y1j22	602	8	steps	step	NNS
cord-023439-r04y1j22	602	9	towards	towards	IN
cord-023439-r04y1j22	602	10	comparing	compare	VBG
cord-023439-r04y1j22	602	11	our	-PRON-	PRP$
cord-023439-r04y1j22	602	12	results	result	NNS
cord-023439-r04y1j22	602	13	with	with	IN
cord-023439-r04y1j22	602	14	those	those	DT
cord-023439-r04y1j22	602	15	of	of	IN
cord-023439-r04y1j22	602	16	other	other	JJ
cord-023439-r04y1j22	602	17	technologies	technology	NNS
cord-023439-r04y1j22	602	18	on	on	IN
cord-023439-r04y1j22	602	19	both	both	CC
cord-023439-r04y1j22	602	20	the	the	DT
cord-023439-r04y1j22	602	21	protein	protein	NN
cord-023439-r04y1j22	602	22	and	and	CC
cord-023439-r04y1j22	602	23	gene	gene	NN
cord-023439-r04y1j22	602	24	level	level	NN
cord-023439-r04y1j22	602	25	.	.	.
cord-023439-r04y1j22	603	1	Due	due	IN
cord-023439-r04y1j22	603	2	to	to	IN
cord-023439-r04y1j22	603	3	the	the	DT
cord-023439-r04y1j22	603	4	complexity	complexity	NN
cord-023439-r04y1j22	603	5	of	of	IN
cord-023439-r04y1j22	603	6	the	the	DT
cord-023439-r04y1j22	603	7	model	model	NN
cord-023439-r04y1j22	603	8	proteome	proteome	NN
cord-023439-r04y1j22	603	9	,	,	,
cord-023439-r04y1j22	603	10	we	-PRON-	PRP
cord-023439-r04y1j22	603	11	also	also	RB
cord-023439-r04y1j22	603	12	examined	examine	VBD
cord-023439-r04y1j22	603	13	the	the	DT
cord-023439-r04y1j22	603	14	possibility	possibility	NN
cord-023439-r04y1j22	603	15	to	to	TO
cord-023439-r04y1j22	603	16	prefractionate	prefractionate	VB
cord-023439-r04y1j22	603	17	the	the	DT
cord-023439-r04y1j22	603	18	proteome	proteome	NN
cord-023439-r04y1j22	603	19	in	in	IN
cord-023439-r04y1j22	603	20	a	a	DT
cord-023439-r04y1j22	603	21	simple	simple	JJ
cord-023439-r04y1j22	603	22	one	one	CD
cord-023439-r04y1j22	603	23	-	-	HYPH
cord-023439-r04y1j22	603	24	step	step	NN
cord-023439-r04y1j22	603	25	procedure	procedure	NN
cord-023439-r04y1j22	603	26	(	(	-LRB-
cord-023439-r04y1j22	603	27	based	base	VBN
cord-023439-r04y1j22	603	28	on	on	IN
cord-023439-r04y1j22	603	29	size	size	NN
cord-023439-r04y1j22	603	30	)	)	-RRB-
cord-023439-r04y1j22	603	31	prior	prior	RB
cord-023439-r04y1j22	603	32	to	to	IN
cord-023439-r04y1j22	603	33	the	the	DT
cord-023439-r04y1j22	603	34	labelling	labelling	NN
cord-023439-r04y1j22	603	35	step	step	NN
cord-023439-r04y1j22	603	36	.	.	.
cord-023439-r04y1j22	604	1	In	in	IN
cord-023439-r04y1j22	604	2	more	more	JJR
cord-023439-r04y1j22	604	3	detail	detail	NN
cord-023439-r04y1j22	604	4	,	,	,
cord-023439-r04y1j22	604	5	the	the	DT
cord-023439-r04y1j22	604	6	sample	sample	NN
cord-023439-r04y1j22	604	7	proteome	proteome	NN
cord-023439-r04y1j22	604	8	was	be	VBD
cord-023439-r04y1j22	604	9	fractionated	fractionate	VBN
cord-023439-r04y1j22	604	10	into	into	IN
cord-023439-r04y1j22	604	11	two	two	CD
cord-023439-r04y1j22	604	12	fractions	fraction	NNS
cord-023439-r04y1j22	604	13	using	use	VBG
cord-023439-r04y1j22	604	14	membrane	membrane	NN
cord-023439-r04y1j22	604	15	devices	device	NNS
cord-023439-r04y1j22	604	16	with	with	IN
cord-023439-r04y1j22	604	17	different	different	JJ
cord-023439-r04y1j22	604	18	molecular	molecular	JJ
cord-023439-r04y1j22	604	19	weight	weight	NN
cord-023439-r04y1j22	604	20	cut	cut	NN
cord-023439-r04y1j22	604	21	-	-	HYPH
cord-023439-r04y1j22	604	22	offs	off	NNS
cord-023439-r04y1j22	604	23	.	.	.
cord-023439-r04y1j22	605	1	The	the	DT
cord-023439-r04y1j22	605	2	results	result	NNS
cord-023439-r04y1j22	605	3	showed	show	VBD
cord-023439-r04y1j22	605	4	that	that	IN
cord-023439-r04y1j22	605	5	the	the	DT
cord-023439-r04y1j22	605	6	fractionation	fractionation	NN
cord-023439-r04y1j22	605	7	considerably	considerably	RB
cord-023439-r04y1j22	605	8	enhanced	enhance	VBD
cord-023439-r04y1j22	605	9	the	the	DT
cord-023439-r04y1j22	605	10	assay	assay	NN
cord-023439-r04y1j22	605	11	sensitivity	sensitivity	NN
cord-023439-r04y1j22	605	12	allowing	allow	VBG
cord-023439-r04y1j22	605	13	cytokines	cytokine	NNS
cord-023439-r04y1j22	605	14	in	in	IN
cord-023439-r04y1j22	605	15	the	the	DT
cord-023439-r04y1j22	605	16	pg	pg	NN
cord-023439-r04y1j22	605	17	/	/	SYM
cord-023439-r04y1j22	605	18	ml	ml	NN
cord-023439-r04y1j22	605	19	range	range	NN
cord-023439-r04y1j22	605	20	to	to	TO
cord-023439-r04y1j22	605	21	be	be	VB
cord-023439-r04y1j22	605	22	readily	readily	RB
cord-023439-r04y1j22	605	23	detectable	detectable	JJ
cord-023439-r04y1j22	605	24	.	.	.
cord-023439-r04y1j22	606	1	The	the	DT
cord-023439-r04y1j22	606	2	Immunomodulatory	Immunomodulatory	NNP
cord-023439-r04y1j22	606	3	Effect	Effect	NNP
cord-023439-r04y1j22	606	4	of	of	IN
cord-023439-r04y1j22	606	5	Heat	Heat	NNP
cord-023439-r04y1j22	606	6	Shock	Shock	NNP
cord-023439-r04y1j22	606	7	Protein	Protein	NNP
cord-023439-r04y1j22	606	8	70	70	CD
cord-023439-r04y1j22	606	9	:	:	:
cord-023439-r04y1j22	606	10	Immunization	immunization	NN
cord-023439-r04y1j22	606	11	with	with	IN
cord-023439-r04y1j22	606	12	a	a	DT
cord-023439-r04y1j22	606	13	DNA	dna	NN
cord-023439-r04y1j22	606	14	Construct	construct	NN
cord-023439-r04y1j22	606	15	Based	base	VBN
cord-023439-r04y1j22	606	16	on	on	IN
cord-023439-r04y1j22	606	17	the	the	DT
cord-023439-r04y1j22	606	18	Malarial	Malarial	NNP
cord-023439-r04y1j22	606	19	Antigen	Antigen	NNP
cord-023439-r04y1j22	606	20	Fused	fuse	VBN
cord-023439-r04y1j22	606	21	with	with	IN
cord-023439-r04y1j22	606	22	a	a	DT
cord-023439-r04y1j22	606	23	Fragment	Fragment	NNP
cord-023439-r04y1j22	606	24	of	of	IN
cord-023439-r04y1j22	606	25	HSP	HSP	NNP
cord-023439-r04y1j22	606	26	70	70	CD
cord-023439-r04y1j22	606	27	Primes	Primes	NNPS
cord-023439-r04y1j22	606	28	for	for	IN
cord-023439-r04y1j22	606	29	a	a	DT
cord-023439-r04y1j22	606	30	Th-1	Th-1	NNP
cord-023439-r04y1j22	606	31	Type	Type	NNP
cord-023439-r04y1j22	606	32	of	of	IN
cord-023439-r04y1j22	606	33	Response	Response	NNP
cord-023439-r04y1j22	606	34	Finding	find	VBG
cord-023439-r04y1j22	606	35	an	an	DT
cord-023439-r04y1j22	606	36	appropriate	appropriate	JJ
cord-023439-r04y1j22	606	37	adjuvant	adjuvant	NN
cord-023439-r04y1j22	606	38	for	for	IN
cord-023439-r04y1j22	606	39	human	human	JJ
cord-023439-r04y1j22	606	40	vaccination	vaccination	NN
cord-023439-r04y1j22	606	41	is	be	VBZ
cord-023439-r04y1j22	606	42	crucial	crucial	JJ
cord-023439-r04y1j22	606	43	.	.	.
cord-023439-r04y1j22	607	1	Heat	heat	NN
cord-023439-r04y1j22	607	2	shock	shock	NN
cord-023439-r04y1j22	607	3	proteins	protein	NNS
cord-023439-r04y1j22	607	4	(	(	-LRB-
cord-023439-r04y1j22	607	5	HSPs	HSPs	NNP
cord-023439-r04y1j22	607	6	)	)	-RRB-
cord-023439-r04y1j22	607	7	act	act	VBP
cord-023439-r04y1j22	607	8	as	as	IN
cord-023439-r04y1j22	607	9	adjuvants	adjuvant	NNS
cord-023439-r04y1j22	607	10	when	when	WRB
cord-023439-r04y1j22	607	11	coadministered	coadministere	VBN
cord-023439-r04y1j22	607	12	with	with	IN
cord-023439-r04y1j22	607	13	peptide	peptide	NN
cord-023439-r04y1j22	607	14	antigens	antigen	NNS
cord-023439-r04y1j22	607	15	or	or	CC
cord-023439-r04y1j22	607	16	given	give	VBN
cord-023439-r04y1j22	607	17	as	as	IN
cord-023439-r04y1j22	607	18	fusion	fusion	NN
cord-023439-r04y1j22	607	19	proteins	protein	NNS
cord-023439-r04y1j22	607	20	.	.	.
cord-023439-r04y1j22	608	1	However	however	RB
cord-023439-r04y1j22	608	2	,	,	,
cord-023439-r04y1j22	608	3	there	there	EX
cord-023439-r04y1j22	608	4	is	be	VBZ
cord-023439-r04y1j22	608	5	a	a	DT
cord-023439-r04y1j22	608	6	potential	potential	JJ
cord-023439-r04y1j22	608	7	risk	risk	NN
cord-023439-r04y1j22	608	8	of	of	IN
cord-023439-r04y1j22	608	9	autoimmunity	autoimmunity	NN
cord-023439-r04y1j22	608	10	when	when	WRB
cord-023439-r04y1j22	608	11	using	use	VBG
cord-023439-r04y1j22	608	12	the	the	DT
cord-023439-r04y1j22	608	13	complete	complete	JJ
cord-023439-r04y1j22	608	14	molecules	molecule	NNS
cord-023439-r04y1j22	608	15	,	,	,
cord-023439-r04y1j22	608	16	because	because	IN
cord-023439-r04y1j22	608	17	HSPs	hsp	NNS
cord-023439-r04y1j22	608	18	are	be	VBP
cord-023439-r04y1j22	608	19	evolutionary	evolutionary	JJ
cord-023439-r04y1j22	608	20	conserved	conserve	VBN
cord-023439-r04y1j22	608	21	.	.	.
cord-023439-r04y1j22	609	1	To	to	TO
cord-023439-r04y1j22	609	2	overcome	overcome	VB
cord-023439-r04y1j22	609	3	this	this	DT
cord-023439-r04y1j22	609	4	,	,	,
cord-023439-r04y1j22	609	5	we	-PRON-	PRP
cord-023439-r04y1j22	609	6	first	first	RB
cord-023439-r04y1j22	609	7	evaluated	evaluate	VBD
cord-023439-r04y1j22	609	8	the	the	DT
cord-023439-r04y1j22	609	9	adjuvant	adjuvant	JJ
cord-023439-r04y1j22	609	10	effect	effect	NN
cord-023439-r04y1j22	609	11	against	against	IN
cord-023439-r04y1j22	609	12	two	two	CD
cord-023439-r04y1j22	609	13	different	different	JJ
cord-023439-r04y1j22	609	14	antigens	antigen	NNS
cord-023439-r04y1j22	609	15	of	of	IN
cord-023439-r04y1j22	609	16	a	a	DT
cord-023439-r04y1j22	609	17	less	less	RBR
cord-023439-r04y1j22	609	18	-	-	HYPH
cord-023439-r04y1j22	609	19	conserved	conserve	VBN
cord-023439-r04y1j22	609	20	fraction	fraction	NN
cord-023439-r04y1j22	609	21	of	of	IN
cord-023439-r04y1j22	609	22	Plasmodium	plasmodium	NN
cord-023439-r04y1j22	609	23	falciparum	falciparum	NN
cord-023439-r04y1j22	609	24	HSP70	HSP70	NNP
cord-023439-r04y1j22	609	25	(	(	-LRB-
cord-023439-r04y1j22	609	26	Pf70C	Pf70C	NNP
cord-023439-r04y1j22	609	27	)	)	-RRB-
cord-023439-r04y1j22	609	28	and	and	CC
cord-023439-r04y1j22	609	29	compared	compare	VBD
cord-023439-r04y1j22	609	30	it	-PRON-	PRP
cord-023439-r04y1j22	609	31	to	to	IN
cord-023439-r04y1j22	609	32	the	the	DT
cord-023439-r04y1j22	609	33	whole	whole	JJ
cord-023439-r04y1j22	609	34	HSP70	HSP70	NNP
cord-023439-r04y1j22	609	35	molecule	molecule	NN
cord-023439-r04y1j22	609	36	from	from	IN
cord-023439-r04y1j22	609	37	Trypanosoma	Trypanosoma	NNP
cord-023439-r04y1j22	609	38	cruzi	cruzi	NNP
cord-023439-r04y1j22	609	39	(	(	-LRB-
cord-023439-r04y1j22	609	40	TcHSP70	TcHSP70	NNP
cord-023439-r04y1j22	609	41	)	)	-RRB-
cord-023439-r04y1j22	609	42	.	.	.
cord-023439-r04y1j22	610	1	We	-PRON-	PRP
cord-023439-r04y1j22	610	2	found	find	VBD
cord-023439-r04y1j22	610	3	that	that	IN
cord-023439-r04y1j22	610	4	Pf70C	Pf70C	NNP
cord-023439-r04y1j22	610	5	exhibited	exhibit	VBD
cord-023439-r04y1j22	610	6	similar	similar	JJ
cord-023439-r04y1j22	610	7	adjuvant	adjuvant	JJ
cord-023439-r04y1j22	610	8	properties	property	NNS
cord-023439-r04y1j22	610	9	as	as	IN
cord-023439-r04y1j22	610	10	the	the	DT
cord-023439-r04y1j22	610	11	whole	whole	JJ
cord-023439-r04y1j22	610	12	molecule	molecule	NN
cord-023439-r04y1j22	610	13	.	.	.
cord-023439-r04y1j22	611	1	We	-PRON-	PRP
cord-023439-r04y1j22	611	2	later	later	RB
cord-023439-r04y1j22	611	3	evaluated	evaluate	VBD
cord-023439-r04y1j22	611	4	the	the	DT
cord-023439-r04y1j22	611	5	adjuvant	adjuvant	JJ
cord-023439-r04y1j22	611	6	potential	potential	NN
cord-023439-r04y1j22	611	7	of	of	IN
cord-023439-r04y1j22	611	8	Pf70C	Pf70C	NNP
cord-023439-r04y1j22	611	9	against	against	IN
cord-023439-r04y1j22	611	10	the	the	DT
cord-023439-r04y1j22	611	11	malarial	malarial	JJ
cord-023439-r04y1j22	611	12	antigen	antigen	NN
cord-023439-r04y1j22	612	1	EB200	eb200	UH
cord-023439-r04y1j22	612	2	in	in	IN
cord-023439-r04y1j22	612	3	a	a	DT
cord-023439-r04y1j22	612	4	chimeric	chimeric	JJ
cord-023439-r04y1j22	612	5	DNA	dna	NN
cord-023439-r04y1j22	612	6	construct	construct	NN
cord-023439-r04y1j22	612	7	.	.	.
cord-023439-r04y1j22	613	1	No	no	DT
cord-023439-r04y1j22	613	2	appreciable	appreciable	JJ
cord-023439-r04y1j22	613	3	levels	level	NNS
cord-023439-r04y1j22	613	4	of	of	IN
cord-023439-r04y1j22	613	5	EB200-specific	EB200-specific	NNP
cord-023439-r04y1j22	613	6	Abstracts	abstract	NNS
cord-023439-r04y1j22	613	7	629	629	CD
cord-023439-r04y1j22	613	8	..................................................................................................................................................................................................	..................................................................................................................................................................................................	.
cord-023439-r04y1j22	614	1	antibodies	antibody	NNS
cord-023439-r04y1j22	614	2	were	be	VBD
cord-023439-r04y1j22	614	3	detected	detect	VBN
cord-023439-r04y1j22	614	4	in	in	IN
cord-023439-r04y1j22	614	5	mice	mouse	NNS
cord-023439-r04y1j22	614	6	immunized	immunize	VBN
cord-023439-r04y1j22	614	7	only	only	RB
cord-023439-r04y1j22	614	8	with	with	IN
cord-023439-r04y1j22	614	9	the	the	DT
cord-023439-r04y1j22	614	10	DNA	dna	NN
cord-023439-r04y1j22	614	11	constructs	construct	NNS
cord-023439-r04y1j22	614	12	.	.	.
cord-023439-r04y1j22	615	1	However	however	RB
cord-023439-r04y1j22	615	2	,	,	,
cord-023439-r04y1j22	615	3	DNA	DNA	NNP
cord-023439-r04y1j22	615	4	primed	prime	VBD
cord-023439-r04y1j22	615	5	the	the	DT
cord-023439-r04y1j22	615	6	immune	immune	JJ
cord-023439-r04y1j22	615	7	system	system	NN
cord-023439-r04y1j22	615	8	,	,	,
cord-023439-r04y1j22	615	9	because	because	IN
cord-023439-r04y1j22	615	10	subsequent	subsequent	JJ
cord-023439-r04y1j22	615	11	challenge	challenge	NN
cord-023439-r04y1j22	615	12	with	with	IN
cord-023439-r04y1j22	615	13	the	the	DT
cord-023439-r04y1j22	615	14	corresponding	corresponding	JJ
cord-023439-r04y1j22	615	15	recombinant	recombinant	JJ
cord-023439-r04y1j22	615	16	fusion	fusion	NN
cord-023439-r04y1j22	615	17	proteins	protein	NNS
cord-023439-r04y1j22	615	18	elicited	elicit	VBD
cord-023439-r04y1j22	615	19	a	a	DT
cord-023439-r04y1j22	615	20	strong	strong	JJ
cord-023439-r04y1j22	615	21	Th-1	Th-1	NNP
cord-023439-r04y1j22	615	22	antibody	antibody	NN
cord-023439-r04y1j22	615	23	response	response	NN
cord-023439-r04y1j22	615	24	.	.	.
cord-023439-r04y1j22	616	1	In	in	IN
cord-023439-r04y1j22	616	2	contrast	contrast	NN
cord-023439-r04y1j22	616	3	,	,	,
cord-023439-r04y1j22	616	4	no	no	DT
cord-023439-r04y1j22	616	5	priming	priming	NN
cord-023439-r04y1j22	616	6	effect	effect	NN
cord-023439-r04y1j22	616	7	was	be	VBD
cord-023439-r04y1j22	616	8	observed	observe	VBN
cord-023439-r04y1j22	616	9	for	for	IN
cord-023439-r04y1j22	616	10	ex	ex	FW
cord-023439-r04y1j22	616	11	vivo	vivo	NNP
cord-023439-r04y1j22	616	12	IFN	IFN	NNP
cord-023439-r04y1j22	616	13	-	-	HYPH
cord-023439-r04y1j22	616	14	g	g	NN
cord-023439-r04y1j22	616	15	production	production	NN
cord-023439-r04y1j22	616	16	but	but	CC
cord-023439-r04y1j22	616	17	stimulation	stimulation	NN
cord-023439-r04y1j22	616	18	with	with	IN
cord-023439-r04y1j22	616	19	the	the	DT
cord-023439-r04y1j22	616	20	HSP	HSP	NNP
cord-023439-r04y1j22	616	21	-	-	HYPH
cord-023439-r04y1j22	616	22	chimeric	chimeric	JJ
cord-023439-r04y1j22	616	23	fusion	fusion	NN
cord-023439-r04y1j22	616	24	protein	protein	NN
cord-023439-r04y1j22	616	25	induced	induce	VBD
cord-023439-r04y1j22	616	26	a	a	DT
cord-023439-r04y1j22	616	27	stronger	strong	JJR
cord-023439-r04y1j22	616	28	secretion	secretion	NN
cord-023439-r04y1j22	616	29	of	of	IN
cord-023439-r04y1j22	616	30	IFN	IFN	NNP
cord-023439-r04y1j22	616	31	-	-	HYPH
cord-023439-r04y1j22	616	32	g	g	NNP
cord-023439-r04y1j22	616	33	in	in	IN
cord-023439-r04y1j22	616	34	vitro	vitro	FW
cord-023439-r04y1j22	616	35	than	than	IN
cord-023439-r04y1j22	616	36	other	other	JJ
cord-023439-r04y1j22	616	37	proteins	protein	NNS
cord-023439-r04y1j22	616	38	used	use	VBN
cord-023439-r04y1j22	616	39	.	.	.
cord-023439-r04y1j22	617	1	These	these	DT
cord-023439-r04y1j22	617	2	results	result	NNS
cord-023439-r04y1j22	617	3	indicate	indicate	VBP
cord-023439-r04y1j22	617	4	that	that	IN
cord-023439-r04y1j22	617	5	the	the	DT
cord-023439-r04y1j22	617	6	use	use	NN
cord-023439-r04y1j22	617	7	of	of	IN
cord-023439-r04y1j22	617	8	HSPs	HSPs	NNP
cord-023439-r04y1j22	617	9	is	be	VBZ
cord-023439-r04y1j22	617	10	promising	promise	VBG
cord-023439-r04y1j22	617	11	in	in	IN
cord-023439-r04y1j22	617	12	the	the	DT
cord-023439-r04y1j22	617	13	design	design	NN
cord-023439-r04y1j22	617	14	of	of	IN
cord-023439-r04y1j22	617	15	new	new	JJ
cord-023439-r04y1j22	617	16	vaccines	vaccine	NNS
cord-023439-r04y1j22	617	17	.	.	.
cord-023439-r04y1j22	618	1	High	High	NNP
cord-023439-r04y1j22	618	2	-	-	HYPH
cord-023439-r04y1j22	618	3	Throughput	Throughput	NNP
cord-023439-r04y1j22	618	4	Proteomics	Proteomics	NNP
cord-023439-r04y1j22	618	5	on	on	IN
cord-023439-r04y1j22	618	6	Antibody	Antibody	NNP
cord-023439-r04y1j22	618	7	-	-	HYPH
cord-023439-r04y1j22	618	8	based	base	VBN
cord-023439-r04y1j22	618	9	Microarrays	microarray	NNS
cord-023439-r04y1j22	618	10	:	:	:
cord-023439-r04y1j22	618	11	the	the	DT
cord-023439-r04y1j22	618	12	Importance	Importance	NNP
cord-023439-r04y1j22	618	13	of	of	IN
cord-023439-r04y1j22	618	14	Probe	Probe	NNP
cord-023439-r04y1j22	618	15	and	and	CC
cord-023439-r04y1j22	618	16	Surface	Surface	NNP
cord-023439-r04y1j22	618	17	Design	Design	NNP
cord-023439-r04y1j22	619	1	In	in	IN
cord-023439-r04y1j22	619	2	analogy	analogy	NN
cord-023439-r04y1j22	619	3	to	to	IN
cord-023439-r04y1j22	619	4	DNA	dna	NN
cord-023439-r04y1j22	619	5	microarrays	microarray	NNS
cord-023439-r04y1j22	619	6	,	,	,
cord-023439-r04y1j22	619	7	protein	protein	NN
cord-023439-r04y1j22	619	8	microarrays	microarray	NNS
cord-023439-r04y1j22	619	9	offer	offer	VBP
cord-023439-r04y1j22	619	10	a	a	DT
cord-023439-r04y1j22	619	11	new	new	JJ
cord-023439-r04y1j22	619	12	distinct	distinct	JJ
cord-023439-r04y1j22	619	13	possibility	possibility	NN
cord-023439-r04y1j22	619	14	to	to	TO
cord-023439-r04y1j22	619	15	perform	perform	VB
cord-023439-r04y1j22	619	16	sensitive	sensitive	JJ
cord-023439-r04y1j22	619	17	highthroughput	highthroughput	NN
cord-023439-r04y1j22	619	18	global	global	JJ
cord-023439-r04y1j22	619	19	proteome	proteome	NN
cord-023439-r04y1j22	619	20	analysis	analysis	NN
cord-023439-r04y1j22	619	21	.	.	.
cord-023439-r04y1j22	620	1	However	however	RB
cord-023439-r04y1j22	620	2	,	,	,
cord-023439-r04y1j22	620	3	the	the	DT
cord-023439-r04y1j22	620	4	development	development	NN
cord-023439-r04y1j22	620	5	of	of	IN
cord-023439-r04y1j22	620	6	the	the	DT
cord-023439-r04y1j22	620	7	protein	protein	NN
cord-023439-r04y1j22	620	8	microarray	microarray	NN
cord-023439-r04y1j22	620	9	technology	technology	NN
cord-023439-r04y1j22	620	10	will	will	MD
cord-023439-r04y1j22	620	11	place	place	VB
cord-023439-r04y1j22	620	12	high	high	JJ
cord-023439-r04y1j22	620	13	demands	demand	NNS
cord-023439-r04y1j22	620	14	upon	upon	IN
cord-023439-r04y1j22	620	15	the	the	DT
cord-023439-r04y1j22	620	16	design	design	NN
cord-023439-r04y1j22	620	17	of	of	IN
cord-023439-r04y1j22	620	18	both	both	DT
cord-023439-r04y1j22	620	19	probes	probe	NNS
cord-023439-r04y1j22	620	20	and	and	CC
cord-023439-r04y1j22	620	21	solid	solid	JJ
cord-023439-r04y1j22	620	22	supports	support	NNS
cord-023439-r04y1j22	620	23	.	.	.
cord-023439-r04y1j22	621	1	The	the	DT
cord-023439-r04y1j22	621	2	analysis	analysis	NN
cord-023439-r04y1j22	621	3	of	of	IN
cord-023439-r04y1j22	621	4	thousands	thousand	NNS
cord-023439-r04y1j22	621	5	of	of	IN
cord-023439-r04y1j22	621	6	heterogeneous	heterogeneous	JJ
cord-023439-r04y1j22	621	7	proteins	protein	NNS
cord-023439-r04y1j22	621	8	on	on	IN
cord-023439-r04y1j22	621	9	a	a	DT
cord-023439-r04y1j22	621	10	single	single	JJ
cord-023439-r04y1j22	621	11	microarray	microarray	NN
cord-023439-r04y1j22	621	12	requires	require	VBZ
cord-023439-r04y1j22	621	13	the	the	DT
cord-023439-r04y1j22	621	14	use	use	NN
cord-023439-r04y1j22	621	15	of	of	IN
cord-023439-r04y1j22	621	16	uniform	uniform	JJ
cord-023439-r04y1j22	621	17	probes	probe	NNS
cord-023439-r04y1j22	621	18	,	,	,
cord-023439-r04y1j22	621	19	such	such	JJ
cord-023439-r04y1j22	621	20	as	as	IN
cord-023439-r04y1j22	621	21	antibodies	antibody	NNS
cord-023439-r04y1j22	621	22	,	,	,
cord-023439-r04y1j22	621	23	directly	directly	RB
cord-023439-r04y1j22	621	24	designed	design	VBN
cord-023439-r04y1j22	621	25	for	for	IN
cord-023439-r04y1j22	621	26	protein	protein	NN
cord-023439-r04y1j22	621	27	microarray	microarray	NN
cord-023439-r04y1j22	621	28	applications	application	NNS
cord-023439-r04y1j22	621	29	.	.	.
cord-023439-r04y1j22	622	1	We	-PRON-	PRP
cord-023439-r04y1j22	622	2	have	have	VBP
cord-023439-r04y1j22	622	3	recently	recently	RB
cord-023439-r04y1j22	622	4	generated	generate	VBN
cord-023439-r04y1j22	622	5	a	a	DT
cord-023439-r04y1j22	622	6	human	human	JJ
cord-023439-r04y1j22	622	7	recombinant	recombinant	JJ
cord-023439-r04y1j22	622	8	single	single	JJ
cord-023439-r04y1j22	622	9	-	-	HYPH
cord-023439-r04y1j22	622	10	chain	chain	NN
cord-023439-r04y1j22	622	11	Fv	Fv	NNP
cord-023439-r04y1j22	622	12	antibody	antibody	NN
cord-023439-r04y1j22	622	13	library	library	NN
cord-023439-r04y1j22	622	14	,	,	,
cord-023439-r04y1j22	622	15	genetically	genetically	RB
cord-023439-r04y1j22	622	16	constructed	construct	VBN
cord-023439-r04y1j22	622	17	around	around	IN
cord-023439-r04y1j22	622	18	one	one	CD
cord-023439-r04y1j22	622	19	framework	framework	NN
cord-023439-r04y1j22	622	20	,	,	,
cord-023439-r04y1j22	622	21	the	the	DT
cord-023439-r04y1j22	622	22	nCoDeR	nCoDeR	NNP
cord-023439-r04y1j22	622	23	-	-	HYPH
cord-023439-r04y1j22	622	24	library	library	NN
cord-023439-r04y1j22	622	25	,	,	,
cord-023439-r04y1j22	622	26	containing	contain	VBG
cord-023439-r04y1j22	622	27	2	2	CD
cord-023439-r04y1j22	622	28	Â	â	CD
cord-023439-r04y1j22	622	29	1010	1010	CD
cord-023439-r04y1j22	622	30	clones	clone	NNS
cord-023439-r04y1j22	622	31	.	.	.
cord-023439-r04y1j22	623	1	Single	single	JJ
cord-023439-r04y1j22	623	2	framework	framework	NN
cord-023439-r04y1j22	623	3	antibody	antibody	NN
cord-023439-r04y1j22	623	4	fragments	fragment	NNS
cord-023439-r04y1j22	623	5	(	(	-LRB-
cord-023439-r04y1j22	623	6	sinFabs	sinFabs	NFP
cord-023439-r04y1j22	623	7	)	)	-RRB-
cord-023439-r04y1j22	623	8	selected	select	VBN
cord-023439-r04y1j22	623	9	from	from	IN
cord-023439-r04y1j22	623	10	this	this	DT
cord-023439-r04y1j22	623	11	library	library	NN
cord-023439-r04y1j22	623	12	were	be	VBD
cord-023439-r04y1j22	623	13	successfully	successfully	RB
cord-023439-r04y1j22	623	14	applied	apply	VBN
cord-023439-r04y1j22	623	15	as	as	IN
cord-023439-r04y1j22	623	16	probes	probe	NNS
cord-023439-r04y1j22	623	17	for	for	IN
cord-023439-r04y1j22	623	18	microarrays	microarray	NNS
cord-023439-r04y1j22	623	19	providing	provide	VBG
cord-023439-r04y1j22	623	20	sensitive	sensitive	JJ
cord-023439-r04y1j22	623	21	detection	detection	NN
cord-023439-r04y1j22	623	22	in	in	IN
cord-023439-r04y1j22	623	23	the	the	DT
cord-023439-r04y1j22	623	24	600	600	CD
cord-023439-r04y1j22	623	25	attomol	attomol	JJ
cord-023439-r04y1j22	623	26	(	(	-LRB-
cord-023439-r04y1j22	623	27	mass	mass	NNP
cord-023439-r04y1j22	623	28	spectrometry	spectrometry	NNP
cord-023439-r04y1j22	623	29	)	)	-RRB-
cord-023439-r04y1j22	623	30	and	and	CC
cord-023439-r04y1j22	623	31	the	the	DT
cord-023439-r04y1j22	623	32	300	300	CD
cord-023439-r04y1j22	623	33	zeptomole	zeptomole	NN
cord-023439-r04y1j22	623	34	range	range	NN
cord-023439-r04y1j22	623	35	(	(	-LRB-
cord-023439-r04y1j22	623	36	fluorescence	fluorescence	NN
cord-023439-r04y1j22	623	37	)	)	-RRB-
cord-023439-r04y1j22	623	38	.	.	.
cord-023439-r04y1j22	624	1	However	however	RB
cord-023439-r04y1j22	624	2	,	,	,
cord-023439-r04y1j22	624	3	the	the	DT
cord-023439-r04y1j22	624	4	choice	choice	NN
cord-023439-r04y1j22	624	5	of	of	IN
cord-023439-r04y1j22	624	6	framework	framework	NN
cord-023439-r04y1j22	624	7	is	be	VBZ
cord-023439-r04y1j22	624	8	critical	critical	JJ
cord-023439-r04y1j22	624	9	.	.	.
cord-023439-r04y1j22	625	1	We	-PRON-	PRP
cord-023439-r04y1j22	625	2	have	have	VBP
cord-023439-r04y1j22	625	3	shown	show	VBN
cord-023439-r04y1j22	625	4	that	that	IN
cord-023439-r04y1j22	625	5	the	the	DT
cord-023439-r04y1j22	625	6	selected	selected	JJ
cord-023439-r04y1j22	625	7	nCoDeR	nCoDeR	NNP
cord-023439-r04y1j22	625	8	framework	framework	NN
cord-023439-r04y1j22	625	9	displayed	display	VBD
cord-023439-r04y1j22	625	10	excellent	excellent	JJ
cord-023439-r04y1j22	625	11	functional	functional	JJ
cord-023439-r04y1j22	625	12	on	on	IN
cord-023439-r04y1j22	625	13	-	-	HYPH
cord-023439-r04y1j22	625	14	chip	chip	NN
cord-023439-r04y1j22	625	15	stability	stability	NN
cord-023439-r04y1j22	625	16	and	and	CC
cord-023439-r04y1j22	625	17	arrayed	array	VBD
cord-023439-r04y1j22	625	18	dehydrated	dehydrated	JJ
cord-023439-r04y1j22	625	19	probes	probe	NNS
cord-023439-r04y1j22	625	20	retained	retain	VBD
cord-023439-r04y1j22	625	21	their	-PRON-	PRP$
cord-023439-r04y1j22	625	22	activity	activity	NN
cord-023439-r04y1j22	625	23	for	for	IN
cord-023439-r04y1j22	625	24	several	several	JJ
cord-023439-r04y1j22	625	25	months	month	NNS
cord-023439-r04y1j22	625	26	.	.	.
cord-023439-r04y1j22	626	1	Furthermore	furthermore	RB
cord-023439-r04y1j22	626	2	,	,	,
cord-023439-r04y1j22	626	3	we	-PRON-	PRP
cord-023439-r04y1j22	626	4	have	have	VBP
cord-023439-r04y1j22	626	5	addressed	address	VBN
cord-023439-r04y1j22	626	6	the	the	DT
cord-023439-r04y1j22	626	7	issues	issue	NNS
cord-023439-r04y1j22	626	8	of	of	IN
cord-023439-r04y1j22	626	9	biocompatibility	biocompatibility	NN
cord-023439-r04y1j22	626	10	of	of	IN
cord-023439-r04y1j22	626	11	the	the	DT
cord-023439-r04y1j22	626	12	solid	solid	JJ
cord-023439-r04y1j22	626	13	support	support	NN
cord-023439-r04y1j22	626	14	and	and	CC
cord-023439-r04y1j22	626	15	immobilization	immobilization	NN
cord-023439-r04y1j22	626	16	strategies	strategy	NNS
cord-023439-r04y1j22	626	17	for	for	IN
cord-023439-r04y1j22	626	18	our	-PRON-	PRP$
cord-023439-r04y1j22	626	19	microarray	microarray	NN
cord-023439-r04y1j22	626	20	setup	setup	NN
cord-023439-r04y1j22	626	21	.	.	.
cord-023439-r04y1j22	627	1	An	an	DT
cord-023439-r04y1j22	627	2	in	in	IN
cord-023439-r04y1j22	627	3	-	-	HYPH
cord-023439-r04y1j22	627	4	house	house	NN
cord-023439-r04y1j22	627	5	-	-	HYPH
cord-023439-r04y1j22	627	6	designed	design	VBN
cord-023439-r04y1j22	627	7	substrate	substrate	NN
cord-023439-r04y1j22	627	8	,	,	,
cord-023439-r04y1j22	627	9	macroporous	macroporous	JJ
cord-023439-r04y1j22	627	10	silicon	silicon	NN
cord-023439-r04y1j22	627	11	coated	coat	VBN
cord-023439-r04y1j22	627	12	with	with	IN
cord-023439-r04y1j22	627	13	nitrocellulose	nitrocellulose	NNS
cord-023439-r04y1j22	627	14	(	(	-LRB-
cord-023439-r04y1j22	627	15	MAP3-NC7	MAP3-NC7	NNP
cord-023439-r04y1j22	627	16	)	)	-RRB-
cord-023439-r04y1j22	627	17	,	,	,
cord-023439-r04y1j22	627	18	displayed	display	VBD
cord-023439-r04y1j22	627	19	properties	property	NNS
cord-023439-r04y1j22	627	20	equal	equal	JJ
cord-023439-r04y1j22	627	21	to	to	IN
cord-023439-r04y1j22	627	22	,	,	,
cord-023439-r04y1j22	627	23	or	or	CC
cord-023439-r04y1j22	627	24	better	well	JJR
cord-023439-r04y1j22	627	25	than	than	IN
cord-023439-r04y1j22	627	26	,	,	,
cord-023439-r04y1j22	627	27	those	those	DT
cord-023439-r04y1j22	627	28	of	of	IN
cord-023439-r04y1j22	627	29	five	five	CD
cord-023439-r04y1j22	627	30	commercially	commercially	RB
cord-023439-r04y1j22	627	31	available	available	JJ
cord-023439-r04y1j22	627	32	supports	support	NNS
cord-023439-r04y1j22	627	33	used	use	VBN
cord-023439-r04y1j22	627	34	as	as	IN
cord-023439-r04y1j22	627	35	reference	reference	NN
cord-023439-r04y1j22	627	36	surfaces	surface	NNS
cord-023439-r04y1j22	627	37	.	.	.
cord-023439-r04y1j22	628	1	We	-PRON-	PRP
cord-023439-r04y1j22	628	2	have	have	VBP
cord-023439-r04y1j22	628	3	also	also	RB
cord-023439-r04y1j22	628	4	evaluated	evaluate	VBN
cord-023439-r04y1j22	628	5	different	different	JJ
cord-023439-r04y1j22	628	6	coupling	coupling	NN
cord-023439-r04y1j22	628	7	strategies	strategy	NNS
cord-023439-r04y1j22	628	8	,	,	,
cord-023439-r04y1j22	628	9	such	such	JJ
cord-023439-r04y1j22	628	10	as	as	IN
cord-023439-r04y1j22	628	11	adsorption	adsorption	NN
cord-023439-r04y1j22	628	12	,	,	,
cord-023439-r04y1j22	628	13	covalent	covalent	JJ
cord-023439-r04y1j22	628	14	coupling	coupling	NN
cord-023439-r04y1j22	628	15	,	,	,
cord-023439-r04y1j22	628	16	diffusion	diffusion	NN
cord-023439-r04y1j22	628	17	and	and	CC
cord-023439-r04y1j22	628	18	affinity	affinity	NN
cord-023439-r04y1j22	628	19	coupling	coupling	NN
cord-023439-r04y1j22	628	20	.	.	.
cord-023439-r04y1j22	629	1	Using	use	VBG
cord-023439-r04y1j22	629	2	a	a	DT
cord-023439-r04y1j22	629	3	novel	novel	JJ
cord-023439-r04y1j22	629	4	affinity	affinity	NN
cord-023439-r04y1j22	629	5	tag	tag	NN
cord-023439-r04y1j22	629	6	,	,	,
cord-023439-r04y1j22	629	7	the	the	DT
cord-023439-r04y1j22	629	8	double-(his)6-tag	double-(his)6-tag	NN
cord-023439-r04y1j22	629	9	,	,	,
cord-023439-r04y1j22	629	10	we	-PRON-	PRP
cord-023439-r04y1j22	629	11	increased	increase	VBD
cord-023439-r04y1j22	629	12	the	the	DT
cord-023439-r04y1j22	629	13	binding	binding	JJ
cord-023439-r04y1j22	629	14	efficiency	efficiency	NN
cord-023439-r04y1j22	629	15	of	of	IN
cord-023439-r04y1j22	629	16	sinFab	sinfab	NN
cord-023439-r04y1j22	629	17	-	-	HYPH
cord-023439-r04y1j22	629	18	molecules	molecule	NNS
cord-023439-r04y1j22	629	19	to	to	TO
cord-023439-r04y1j22	629	20	Ni2	ni2	VB
cord-023439-r04y1j22	629	21	þ	þ	NNP
cord-023439-r04y1j22	629	22	-coated	-coated	JJ
cord-023439-r04y1j22	629	23	solid	solid	JJ
cord-023439-r04y1j22	629	24	supports	support	NNS
cord-023439-r04y1j22	629	25	,	,	,
cord-023439-r04y1j22	629	26	thereby	thereby	RB
cord-023439-r04y1j22	629	27	allowing	allow	VBG
cord-023439-r04y1j22	629	28	nonpurified	nonpurifie	VBN
cord-023439-r04y1j22	629	29	probes	probe	NNS
cord-023439-r04y1j22	629	30	to	to	TO
cord-023439-r04y1j22	629	31	be	be	VB
cord-023439-r04y1j22	629	32	directly	directly	RB
cord-023439-r04y1j22	629	33	applied	apply	VBN
cord-023439-r04y1j22	629	34	.	.	.
cord-023439-r04y1j22	630	1	The	the	DT
cord-023439-r04y1j22	630	2	mannan	mannan	NN
cord-023439-r04y1j22	630	3	-	-	HYPH
cord-023439-r04y1j22	630	4	binding	bind	VBG
cord-023439-r04y1j22	630	5	lectin	lectin	NN
cord-023439-r04y1j22	630	6	(	(	-LRB-
cord-023439-r04y1j22	630	7	MBL	MBL	NNP
cord-023439-r04y1j22	630	8	)	)	-RRB-
cord-023439-r04y1j22	630	9	pathway	pathway	NN
cord-023439-r04y1j22	630	10	is	be	VBZ
cord-023439-r04y1j22	630	11	part	part	NN
cord-023439-r04y1j22	630	12	of	of	IN
cord-023439-r04y1j22	630	13	the	the	DT
cord-023439-r04y1j22	630	14	innate	innate	JJ
cord-023439-r04y1j22	630	15	immune	immune	JJ
cord-023439-r04y1j22	630	16	system	system	NN
cord-023439-r04y1j22	630	17	providing	provide	VBG
cord-023439-r04y1j22	630	18	a	a	DT
cord-023439-r04y1j22	630	19	first	first	JJ
cord-023439-r04y1j22	630	20	line	line	NN
cord-023439-r04y1j22	630	21	of	of	IN
cord-023439-r04y1j22	630	22	defence	defence	NN
cord-023439-r04y1j22	630	23	against	against	IN
cord-023439-r04y1j22	630	24	infections	infection	NNS
cord-023439-r04y1j22	630	25	.	.	.
cord-023439-r04y1j22	631	1	MBL	MBL	NNP
cord-023439-r04y1j22	631	2	and	and	CC
cord-023439-r04y1j22	631	3	ficolins	ficolin	NNS
cord-023439-r04y1j22	631	4	circulate	circulate	VBP
cord-023439-r04y1j22	631	5	in	in	IN
cord-023439-r04y1j22	631	6	complexes	complex	NNS
cord-023439-r04y1j22	631	7	with	with	IN
cord-023439-r04y1j22	631	8	MBL	MBL	NNP
cord-023439-r04y1j22	631	9	-	-	HYPH
cord-023439-r04y1j22	631	10	associated	associate	VBN
cord-023439-r04y1j22	631	11	serine	serine	NN
cord-023439-r04y1j22	631	12	proteases	protease	NNS
cord-023439-r04y1j22	631	13	(	(	-LRB-
cord-023439-r04y1j22	631	14	MASP-1	MASP-1	NNP
cord-023439-r04y1j22	631	15	,	,	,
cord-023439-r04y1j22	631	16	-2	-2	NNP
cord-023439-r04y1j22	631	17	and	and	CC
cord-023439-r04y1j22	631	18	-3	-3	NNP
cord-023439-r04y1j22	631	19	)	)	-RRB-
cord-023439-r04y1j22	631	20	.	.	.
cord-023439-r04y1j22	632	1	After	after	IN
cord-023439-r04y1j22	632	2	recognition	recognition	NN
cord-023439-r04y1j22	632	3	of	of	IN
cord-023439-r04y1j22	632	4	a	a	DT
cord-023439-r04y1j22	632	5	microorganism	microorganism	NN
cord-023439-r04y1j22	632	6	by	by	IN
cord-023439-r04y1j22	632	7	MBL	MBL	NNP
cord-023439-r04y1j22	632	8	,	,	,
cord-023439-r04y1j22	632	9	activation	activation	NN
cord-023439-r04y1j22	632	10	of	of	IN
cord-023439-r04y1j22	632	11	the	the	DT
cord-023439-r04y1j22	632	12	complement	complement	JJ
cord-023439-r04y1j22	632	13	system	system	NN
cord-023439-r04y1j22	632	14	occurs	occur	VBZ
cord-023439-r04y1j22	632	15	.	.	.
cord-023439-r04y1j22	633	1	MASP-1	MASP-1	NNP
cord-023439-r04y1j22	633	2	and	and	CC
cord-023439-r04y1j22	633	3	MASP-3	MASP-3	NNP
cord-023439-r04y1j22	633	4	share	share	VBP
cord-023439-r04y1j22	633	5	five	five	CD
cord-023439-r04y1j22	633	6	domains	domain	NNS
cord-023439-r04y1j22	633	7	(	(	-LRB-
cord-023439-r04y1j22	633	8	making	make	VBG
cord-023439-r04y1j22	633	9	up	up	RP
cord-023439-r04y1j22	633	10	the	the	DT
cord-023439-r04y1j22	633	11	so	so	RB
cord-023439-r04y1j22	633	12	-	-	HYPH
cord-023439-r04y1j22	633	13	called	call	VBN
cord-023439-r04y1j22	633	14	A	a	NN
cord-023439-r04y1j22	633	15	-	-	HYPH
cord-023439-r04y1j22	633	16	chain	chain	NN
cord-023439-r04y1j22	633	17	)	)	-RRB-
cord-023439-r04y1j22	633	18	,	,	,
cord-023439-r04y1j22	633	19	whereas	whereas	IN
cord-023439-r04y1j22	633	20	they	-PRON-	PRP
cord-023439-r04y1j22	633	21	have	have	VBP
cord-023439-r04y1j22	633	22	unique	unique	JJ
cord-023439-r04y1j22	633	23	protease	protease	NN
cord-023439-r04y1j22	633	24	domains	domain	NNS
cord-023439-r04y1j22	633	25	(	(	-LRB-
cord-023439-r04y1j22	633	26	B	b	NN
cord-023439-r04y1j22	633	27	-	-	HYPH
cord-023439-r04y1j22	633	28	chains	chain	NNS
cord-023439-r04y1j22	633	29	)	)	-RRB-
cord-023439-r04y1j22	633	30	.	.	.
cord-023439-r04y1j22	634	1	Before	before	IN
cord-023439-r04y1j22	634	2	the	the	DT
cord-023439-r04y1j22	634	3	identification	identification	NN
cord-023439-r04y1j22	634	4	of	of	IN
cord-023439-r04y1j22	634	5	MASP-3	MASP-3	NNP
cord-023439-r04y1j22	634	6	,	,	,
cord-023439-r04y1j22	634	7	an	an	DT
cord-023439-r04y1j22	634	8	assay	assay	NN
cord-023439-r04y1j22	634	9	for	for	IN
cord-023439-r04y1j22	634	10	MASP	MASP	NNP
cord-023439-r04y1j22	634	11	was	be	VBD
cord-023439-r04y1j22	634	12	presented	present	VBN
cord-023439-r04y1j22	634	13	,	,	,
cord-023439-r04y1j22	634	14	based	base	VBN
cord-023439-r04y1j22	634	15	on	on	IN
cord-023439-r04y1j22	634	16	antibodies	antibody	NNS
cord-023439-r04y1j22	634	17	against	against	IN
cord-023439-r04y1j22	634	18	the	the	DT
cord-023439-r04y1j22	634	19	A	A	NNP
cord-023439-r04y1j22	634	20	-	-	HYPH
cord-023439-r04y1j22	634	21	chain	chain	NN
cord-023439-r04y1j22	634	22	of	of	IN
cord-023439-r04y1j22	634	23	MASP-1	MASP-1	NNP
cord-023439-r04y1j22	634	24	.	.	.
cord-023439-r04y1j22	635	1	With	with	IN
cord-023439-r04y1j22	635	2	the	the	DT
cord-023439-r04y1j22	635	3	new	new	JJ
cord-023439-r04y1j22	635	4	knowledge	knowledge	NN
cord-023439-r04y1j22	635	5	of	of	IN
cord-023439-r04y1j22	635	6	the	the	DT
cord-023439-r04y1j22	635	7	three	three	CD
cord-023439-r04y1j22	635	8	MASPs	masp	NNS
cord-023439-r04y1j22	635	9	,	,	,
cord-023439-r04y1j22	635	10	and	and	CC
cord-023439-r04y1j22	635	11	the	the	DT
cord-023439-r04y1j22	635	12	sharing	sharing	NN
cord-023439-r04y1j22	635	13	of	of	IN
cord-023439-r04y1j22	635	14	domains	domain	NNS
cord-023439-r04y1j22	635	15	by	by	IN
cord-023439-r04y1j22	635	16	MASP-1	MASP-1	NNP
cord-023439-r04y1j22	635	17	and	and	CC
cord-023439-r04y1j22	635	18	MASP-3	MASP-3	NNP
cord-023439-r04y1j22	635	19	,	,	,
cord-023439-r04y1j22	635	20	assays	assay	NNS
cord-023439-r04y1j22	635	21	specific	specific	JJ
cord-023439-r04y1j22	635	22	for	for	IN
cord-023439-r04y1j22	635	23	the	the	DT
cord-023439-r04y1j22	635	24	protease	protease	NN
cord-023439-r04y1j22	635	25	domains	domain	NNS
cord-023439-r04y1j22	635	26	have	have	VBP
cord-023439-r04y1j22	635	27	to	to	TO
cord-023439-r04y1j22	635	28	be	be	VB
cord-023439-r04y1j22	635	29	constructed	construct	VBN
cord-023439-r04y1j22	635	30	,	,	,
cord-023439-r04y1j22	635	31	if	if	IN
cord-023439-r04y1j22	635	32	one	one	PRP
cord-023439-r04y1j22	635	33	wishes	wish	VBZ
cord-023439-r04y1j22	635	34	to	to	TO
cord-023439-r04y1j22	635	35	measure	measure	VB
cord-023439-r04y1j22	635	36	the	the	DT
cord-023439-r04y1j22	635	37	proteins	protein	NNS
cord-023439-r04y1j22	635	38	individually	individually	RB
cord-023439-r04y1j22	635	39	.	.	.
cord-023439-r04y1j22	636	1	We	-PRON-	PRP
cord-023439-r04y1j22	636	2	present	present	VBP
cord-023439-r04y1j22	636	3	an	an	DT
cord-023439-r04y1j22	636	4	assay	assay	NN
cord-023439-r04y1j22	636	5	for	for	IN
cord-023439-r04y1j22	636	6	quantifying	quantify	VBG
cord-023439-r04y1j22	636	7	total	total	JJ
cord-023439-r04y1j22	636	8	MASP-3	masp-3	NN
cord-023439-r04y1j22	636	9	in	in	IN
cord-023439-r04y1j22	636	10	plasma	plasma	NN
cord-023439-r04y1j22	636	11	and	and	CC
cord-023439-r04y1j22	636	12	serum	serum	NN
cord-023439-r04y1j22	636	13	samples	sample	NNS
cord-023439-r04y1j22	636	14	.	.	.
cord-023439-r04y1j22	637	1	The	the	DT
cord-023439-r04y1j22	637	2	assay	assay	NN
cord-023439-r04y1j22	637	3	is	be	VBZ
cord-023439-r04y1j22	637	4	a	a	DT
cord-023439-r04y1j22	637	5	sandwich	sandwich	NN
cord-023439-r04y1j22	637	6	-	-	HYPH
cord-023439-r04y1j22	637	7	type	type	NN
cord-023439-r04y1j22	637	8	assay	assay	NN
cord-023439-r04y1j22	637	9	using	use	VBG
cord-023439-r04y1j22	637	10	as	as	IN
cord-023439-r04y1j22	637	11	catching	catch	VBG
cord-023439-r04y1j22	637	12	antibody	antibody	NN
cord-023439-r04y1j22	637	13	a	a	DT
cord-023439-r04y1j22	637	14	monoclonal	monoclonal	JJ
cord-023439-r04y1j22	637	15	antibody	antibody	NN
cord-023439-r04y1j22	637	16	against	against	IN
cord-023439-r04y1j22	637	17	the	the	DT
cord-023439-r04y1j22	637	18	common	common	JJ
cord-023439-r04y1j22	637	19	A	a	NN
cord-023439-r04y1j22	637	20	-	-	HYPH
cord-023439-r04y1j22	637	21	chain	chain	NN
cord-023439-r04y1j22	637	22	of	of	IN
cord-023439-r04y1j22	637	23	MASP-1/3	MASP-1/3	NNP
cord-023439-r04y1j22	637	24	and	and	CC
cord-023439-r04y1j22	637	25	a	a	DT
cord-023439-r04y1j22	637	26	developing	develop	VBG
cord-023439-r04y1j22	637	27	secondary	secondary	JJ
cord-023439-r04y1j22	637	28	antibody	antibody	NN
cord-023439-r04y1j22	637	29	against	against	IN
cord-023439-r04y1j22	637	30	the	the	DT
cord-023439-r04y1j22	637	31	C	C	NNP
cord-023439-r04y1j22	637	32	-	-	HYPH
cord-023439-r04y1j22	637	33	terminal	terminal	NN
cord-023439-r04y1j22	637	34	part	part	NN
cord-023439-r04y1j22	637	35	of	of	IN
cord-023439-r04y1j22	637	36	the	the	DT
cord-023439-r04y1j22	637	37	protease	protease	NN
cord-023439-r04y1j22	637	38	domain	domain	NN
cord-023439-r04y1j22	637	39	of	of	IN
cord-023439-r04y1j22	637	40	MASP-3	MASP-3	NNP
cord-023439-r04y1j22	637	41	.	.	.
cord-023439-r04y1j22	638	1	We	-PRON-	PRP
cord-023439-r04y1j22	638	2	have	have	VBP
cord-023439-r04y1j22	638	3	used	use	VBN
cord-023439-r04y1j22	638	4	this	this	DT
cord-023439-r04y1j22	638	5	assay	assay	NN
cord-023439-r04y1j22	638	6	for	for	IN
cord-023439-r04y1j22	638	7	estimating	estimate	VBG
cord-023439-r04y1j22	638	8	the	the	DT
cord-023439-r04y1j22	638	9	normal	normal	JJ
cord-023439-r04y1j22	638	10	concentration	concentration	NN
cord-023439-r04y1j22	638	11	of	of	IN
cord-023439-r04y1j22	638	12	the	the	DT
cord-023439-r04y1j22	638	13	protein	protein	NN
cord-023439-r04y1j22	638	14	as	as	RB
cord-023439-r04y1j22	638	15	well	well	RB
cord-023439-r04y1j22	638	16	as	as	IN
cord-023439-r04y1j22	638	17	the	the	DT
cord-023439-r04y1j22	638	18	concentration	concentration	NN
cord-023439-r04y1j22	638	19	in	in	IN
cord-023439-r04y1j22	638	20	patients	patient	NNS
cord-023439-r04y1j22	638	21	and	and	CC
cord-023439-r04y1j22	638	22	also	also	RB
cord-023439-r04y1j22	638	23	for	for	IN
cord-023439-r04y1j22	638	24	characterizing	characterize	VBG
cord-023439-r04y1j22	638	25	by	by	IN
cord-023439-r04y1j22	638	26	gel	gel	NN
cord-023439-r04y1j22	638	27	permeation	permeation	NN
cord-023439-r04y1j22	638	28	chromatography	chromatography	NN
cord-023439-r04y1j22	638	29	the	the	DT
cord-023439-r04y1j22	638	30	MASP-3	MASP-3	NNP
cord-023439-r04y1j22	638	31	protein	protein	NN
cord-023439-r04y1j22	638	32	in	in	IN
cord-023439-r04y1j22	638	33	serum	serum	NN
cord-023439-r04y1j22	638	34	.	.	.
cord-023439-r04y1j22	639	1	Inducible	inducible	JJ
cord-023439-r04y1j22	639	2	costimulator	costimulator	NN
cord-023439-r04y1j22	639	3	ligand	ligand	NN
cord-023439-r04y1j22	639	4	(	(	-LRB-
cord-023439-r04y1j22	639	5	ICOSL	ICOSL	NNP
cord-023439-r04y1j22	639	6	)	)	-RRB-
cord-023439-r04y1j22	639	7	is	be	VBZ
cord-023439-r04y1j22	639	8	a	a	DT
cord-023439-r04y1j22	639	9	costimulatory	costimulatory	NN
cord-023439-r04y1j22	639	10	molecule	molecule	NN
cord-023439-r04y1j22	639	11	related	relate	VBN
cord-023439-r04y1j22	639	12	to	to	IN
cord-023439-r04y1j22	639	13	B7.1	B7.1	NNP
cord-023439-r04y1j22	639	14	(	(	-LRB-
cord-023439-r04y1j22	639	15	CD80	CD80	NNP
cord-023439-r04y1j22	639	16	)	)	-RRB-
cord-023439-r04y1j22	639	17	and	and	CC
cord-023439-r04y1j22	639	18	B7.2	B7.2	NNP
cord-023439-r04y1j22	639	19	(	(	-LRB-
cord-023439-r04y1j22	639	20	CD86	CD86	NNP
cord-023439-r04y1j22	639	21	)	)	-RRB-
cord-023439-r04y1j22	639	22	.	.	.
cord-023439-r04y1j22	640	1	B	b	NN
cord-023439-r04y1j22	640	2	cells	cell	NNS
cord-023439-r04y1j22	640	3	,	,	,
cord-023439-r04y1j22	640	4	monocytes	monocyte	NNS
cord-023439-r04y1j22	640	5	,	,	,
cord-023439-r04y1j22	640	6	dendritic	dendritic	JJ
cord-023439-r04y1j22	640	7	cells	cell	NNS
cord-023439-r04y1j22	640	8	and	and	CC
cord-023439-r04y1j22	640	9	endothelial	endothelial	JJ
cord-023439-r04y1j22	640	10	cells	cell	NNS
cord-023439-r04y1j22	640	11	express	express	VBP
cord-023439-r04y1j22	640	12	ICOSL	ICOSL	NNP
cord-023439-r04y1j22	640	13	.	.	.
cord-023439-r04y1j22	641	1	Inducible	inducible	JJ
cord-023439-r04y1j22	641	2	costimulator	costimulator	NN
cord-023439-r04y1j22	641	3	(	(	-LRB-
cord-023439-r04y1j22	641	4	ICOS	ICOS	NNP
cord-023439-r04y1j22	641	5	)	)	-RRB-
cord-023439-r04y1j22	641	6	interacts	interact	VBZ
cord-023439-r04y1j22	641	7	with	with	IN
cord-023439-r04y1j22	641	8	ICOSL	ICOSL	NNP
cord-023439-r04y1j22	641	9	,	,	,
cord-023439-r04y1j22	641	10	and	and	CC
cord-023439-r04y1j22	641	11	this	this	DT
cord-023439-r04y1j22	641	12	interaction	interaction	NN
cord-023439-r04y1j22	641	13	leads	lead	VBZ
cord-023439-r04y1j22	641	14	to	to	IN
cord-023439-r04y1j22	641	15	signals	signal	NNS
cord-023439-r04y1j22	641	16	involved	involve	VBN
cord-023439-r04y1j22	641	17	in	in	IN
cord-023439-r04y1j22	641	18	isotype	isotype	NN
cord-023439-r04y1j22	641	19	switching	switch	VBG
cord-023439-r04y1j22	641	20	and	and	CC
cord-023439-r04y1j22	641	21	the	the	DT
cord-023439-r04y1j22	641	22	development	development	NN
cord-023439-r04y1j22	641	23	of	of	IN
cord-023439-r04y1j22	641	24	immunological	immunological	JJ
cord-023439-r04y1j22	641	25	memory	memory	NN
cord-023439-r04y1j22	641	26	.	.	.
cord-023439-r04y1j22	642	1	Hitherto	Hitherto	VBN
cord-023439-r04y1j22	642	2	,	,	,
cord-023439-r04y1j22	642	3	no	no	DT
cord-023439-r04y1j22	642	4	polymorphisms	polymorphism	NNS
cord-023439-r04y1j22	642	5	of	of	IN
cord-023439-r04y1j22	642	6	this	this	DT
cord-023439-r04y1j22	642	7	gene	gene	NN
cord-023439-r04y1j22	642	8	have	have	VBP
cord-023439-r04y1j22	642	9	been	be	VBN
cord-023439-r04y1j22	642	10	described	describe	VBN
cord-023439-r04y1j22	642	11	.	.	.
cord-023439-r04y1j22	643	1	The	the	DT
cord-023439-r04y1j22	643	2	aim	aim	NN
cord-023439-r04y1j22	643	3	of	of	IN
cord-023439-r04y1j22	643	4	this	this	DT
cord-023439-r04y1j22	643	5	study	study	NN
cord-023439-r04y1j22	643	6	was	be	VBD
cord-023439-r04y1j22	643	7	to	to	TO
cord-023439-r04y1j22	643	8	reveal	reveal	VB
cord-023439-r04y1j22	643	9	variation	variation	NN
cord-023439-r04y1j22	643	10	of	of	IN
cord-023439-r04y1j22	643	11	the	the	DT
cord-023439-r04y1j22	643	12	ICOSL	ICOSL	NNP
cord-023439-r04y1j22	643	13	gene	gene	NN
cord-023439-r04y1j22	643	14	in	in	IN
cord-023439-r04y1j22	643	15	normal	normal	JJ
cord-023439-r04y1j22	643	16	individuals	individual	NNS
cord-023439-r04y1j22	643	17	.	.	.
cord-023439-r04y1j22	644	1	All	all	DT
cord-023439-r04y1j22	644	2	eight	eight	CD
cord-023439-r04y1j22	644	3	exons	exon	NNS
cord-023439-r04y1j22	644	4	,	,	,
cord-023439-r04y1j22	644	5	except	except	IN
cord-023439-r04y1j22	644	6	exon	exon	NN
cord-023439-r04y1j22	644	7	1	1	CD
cord-023439-r04y1j22	644	8	,	,	,
cord-023439-r04y1j22	644	9	were	be	VBD
cord-023439-r04y1j22	644	10	sequenced	sequence	VBN
cord-023439-r04y1j22	644	11	with	with	IN
cord-023439-r04y1j22	644	12	flanking	flank	VBG
cord-023439-r04y1j22	644	13	introns	intron	NNS
cord-023439-r04y1j22	644	14	in	in	IN
cord-023439-r04y1j22	644	15	10	10	CD
cord-023439-r04y1j22	644	16	healthy	healthy	JJ
cord-023439-r04y1j22	644	17	blood	blood	NN
cord-023439-r04y1j22	644	18	donors	donor	NNS
cord-023439-r04y1j22	644	19	.	.	.
cord-023439-r04y1j22	645	1	Eight	eight	CD
cord-023439-r04y1j22	645	2	single	single	JJ
cord-023439-r04y1j22	645	3	nucleotide	nucleotide	JJ
cord-023439-r04y1j22	645	4	polymorphisms	polymorphism	NNS
cord-023439-r04y1j22	645	5	(	(	-LRB-
cord-023439-r04y1j22	645	6	SNPs	SNPs	NNP
cord-023439-r04y1j22	645	7	)	)	-RRB-
cord-023439-r04y1j22	645	8	and	and	CC
cord-023439-r04y1j22	645	9	two	two	CD
cord-023439-r04y1j22	645	10	length	length	NN
cord-023439-r04y1j22	645	11	polymorphisms	polymorphism	NNS
cord-023439-r04y1j22	645	12	were	be	VBD
cord-023439-r04y1j22	645	13	found	find	VBN
cord-023439-r04y1j22	645	14	.	.	.
cord-023439-r04y1j22	646	1	One	one	CD
cord-023439-r04y1j22	646	2	of	of	IN
cord-023439-r04y1j22	646	3	the	the	DT
cord-023439-r04y1j22	646	4	SNPs	snp	NNS
cord-023439-r04y1j22	646	5	was	be	VBD
cord-023439-r04y1j22	646	6	found	find	VBN
cord-023439-r04y1j22	646	7	in	in	IN
cord-023439-r04y1j22	646	8	the	the	DT
cord-023439-r04y1j22	646	9	coding	code	VBG
cord-023439-r04y1j22	646	10	regions	region	NNS
cord-023439-r04y1j22	646	11	of	of	IN
cord-023439-r04y1j22	646	12	the	the	DT
cord-023439-r04y1j22	646	13	gene	gene	NN
cord-023439-r04y1j22	646	14	.	.	.
cord-023439-r04y1j22	647	1	The	the	DT
cord-023439-r04y1j22	647	2	base	base	NN
cord-023439-r04y1j22	647	3	involved	involve	VBN
cord-023439-r04y1j22	647	4	was	be	VBD
cord-023439-r04y1j22	647	5	located	locate	VBN
cord-023439-r04y1j22	647	6	in	in	IN
cord-023439-r04y1j22	647	7	exon	exon	NN
cord-023439-r04y1j22	647	8	3	3	CD
cord-023439-r04y1j22	647	9	and	and	CC
cord-023439-r04y1j22	647	10	caused	cause	VBD
cord-023439-r04y1j22	647	11	a	a	DT
cord-023439-r04y1j22	647	12	conservative	conservative	JJ
cord-023439-r04y1j22	647	13	amino	amino	NN
cord-023439-r04y1j22	647	14	acid	acid	NN
cord-023439-r04y1j22	647	15	change	change	NN
cord-023439-r04y1j22	647	16	from	from	IN
cord-023439-r04y1j22	647	17	valine	valine	NN
cord-023439-r04y1j22	647	18	(	(	-LRB-
cord-023439-r04y1j22	647	19	GTT	GTT	NNP
cord-023439-r04y1j22	647	20	)	)	-RRB-
cord-023439-r04y1j22	647	21	to	to	IN
cord-023439-r04y1j22	647	22	isoleucine	isoleucine	NNP
cord-023439-r04y1j22	647	23	(	(	-LRB-
cord-023439-r04y1j22	647	24	ATT	ATT	NNP
cord-023439-r04y1j22	647	25	)	)	-RRB-
cord-023439-r04y1j22	647	26	.	.	.
cord-023439-r04y1j22	648	1	Three	three	CD
cord-023439-r04y1j22	648	2	individuals	individual	NNS
cord-023439-r04y1j22	648	3	were	be	VBD
cord-023439-r04y1j22	648	4	heterozygous	heterozygous	JJ
cord-023439-r04y1j22	648	5	G	G	NNP
cord-023439-r04y1j22	648	6	/	/	SYM
cord-023439-r04y1j22	648	7	A	a	NN
cord-023439-r04y1j22	648	8	for	for	IN
cord-023439-r04y1j22	648	9	the	the	DT
cord-023439-r04y1j22	648	10	exon	exon	NN
cord-023439-r04y1j22	648	11	polymorphism	polymorphism	NN
cord-023439-r04y1j22	648	12	,	,	,
cord-023439-r04y1j22	648	13	while	while	IN
cord-023439-r04y1j22	648	14	the	the	DT
cord-023439-r04y1j22	648	15	remaining	remain	VBG
cord-023439-r04y1j22	648	16	seven	seven	CD
cord-023439-r04y1j22	648	17	individuals	individual	NNS
cord-023439-r04y1j22	648	18	were	be	VBD
cord-023439-r04y1j22	648	19	homozygous	homozygous	JJ
cord-023439-r04y1j22	648	20	for	for	IN
cord-023439-r04y1j22	649	1	the	the	DT
cord-023439-r04y1j22	649	2	wildtype	wildtype	JJ
cord-023439-r04y1j22	649	3	G	G	NNP
cord-023439-r04y1j22	649	4	/	/	SYM
cord-023439-r04y1j22	649	5	G.	G.	NNP
cord-023439-r04y1j22	649	6	Exon	Exon	NNP
cord-023439-r04y1j22	649	7	3	3	CD
cord-023439-r04y1j22	649	8	encodes	encode	VBZ
cord-023439-r04y1j22	649	9	the	the	DT
cord-023439-r04y1j22	649	10	immunoglobulin	immunoglobulin	NN
cord-023439-r04y1j22	649	11	variable	variable	NN
cord-023439-r04y1j22	649	12	(	(	-LRB-
cord-023439-r04y1j22	649	13	IgV)-like	IgV)-like	NNP
cord-023439-r04y1j22	649	14	domain	domain	NN
cord-023439-r04y1j22	649	15	of	of	IN
cord-023439-r04y1j22	649	16	the	the	DT
cord-023439-r04y1j22	649	17	molecule	molecule	NN
cord-023439-r04y1j22	649	18	which	which	WDT
cord-023439-r04y1j22	649	19	is	be	VBZ
cord-023439-r04y1j22	649	20	situated	situate	VBN
cord-023439-r04y1j22	649	21	outside	outside	IN
cord-023439-r04y1j22	649	22	the	the	DT
cord-023439-r04y1j22	649	23	cell	cell	NN
cord-023439-r04y1j22	649	24	.	.	.
cord-023439-r04y1j22	650	1	This	this	DT
cord-023439-r04y1j22	650	2	means	mean	VBZ
cord-023439-r04y1j22	650	3	that	that	IN
cord-023439-r04y1j22	650	4	the	the	DT
cord-023439-r04y1j22	650	5	amino	amino	NN
cord-023439-r04y1j22	650	6	acid	acid	NN
cord-023439-r04y1j22	650	7	could	could	MD
cord-023439-r04y1j22	650	8	be	be	VB
cord-023439-r04y1j22	650	9	critical	critical	JJ
cord-023439-r04y1j22	650	10	for	for	IN
cord-023439-r04y1j22	650	11	the	the	DT
cord-023439-r04y1j22	650	12	stability	stability	NN
cord-023439-r04y1j22	650	13	of	of	IN
cord-023439-r04y1j22	650	14	the	the	DT
cord-023439-r04y1j22	650	15	molecule	molecule	NN
cord-023439-r04y1j22	650	16	or	or	CC
cord-023439-r04y1j22	650	17	could	could	MD
cord-023439-r04y1j22	650	18	constitute	constitute	VB
cord-023439-r04y1j22	650	19	part	part	NN
cord-023439-r04y1j22	650	20	of	of	IN
cord-023439-r04y1j22	650	21	the	the	DT
cord-023439-r04y1j22	650	22	binding	binding	NN
cord-023439-r04y1j22	650	23	site	site	NN
cord-023439-r04y1j22	650	24	for	for	IN
cord-023439-r04y1j22	650	25	ICOS	ICOS	NNP
cord-023439-r04y1j22	650	26	.	.	.
cord-023439-r04y1j22	651	1	The	the	DT
cord-023439-r04y1j22	651	2	results	result	NNS
cord-023439-r04y1j22	651	3	form	form	VBP
cord-023439-r04y1j22	651	4	the	the	DT
cord-023439-r04y1j22	651	5	basis	basis	NN
cord-023439-r04y1j22	651	6	for	for	IN
cord-023439-r04y1j22	651	7	further	further	JJ
cord-023439-r04y1j22	651	8	experiments	experiment	NNS
cord-023439-r04y1j22	651	9	to	to	TO
cord-023439-r04y1j22	651	10	find	find	VB
cord-023439-r04y1j22	651	11	possible	possible	JJ
cord-023439-r04y1j22	651	12	associations	association	NNS
cord-023439-r04y1j22	651	13	of	of	IN
cord-023439-r04y1j22	651	14	the	the	DT
cord-023439-r04y1j22	651	15	alleles	allele	NNS
cord-023439-r04y1j22	651	16	to	to	IN
cord-023439-r04y1j22	651	17	diseases	disease	NNS
cord-023439-r04y1j22	651	18	caused	cause	VBN
cord-023439-r04y1j22	651	19	by	by	IN
cord-023439-r04y1j22	651	20	immune	immune	JJ
cord-023439-r04y1j22	651	21	dysregulation	dysregulation	NN
cord-023439-r04y1j22	651	22	.	.	.
cord-023439-r04y1j22	652	1	Especially	especially	RB
cord-023439-r04y1j22	652	2	,	,	,
cord-023439-r04y1j22	652	3	the	the	DT
cord-023439-r04y1j22	652	4	exon	exon	NN
cord-023439-r04y1j22	652	5	3	3	CD
cord-023439-r04y1j22	652	6	variant	variant	NN
cord-023439-r04y1j22	652	7	is	be	VBZ
cord-023439-r04y1j22	652	8	interesting	interesting	JJ
cord-023439-r04y1j22	652	9	and	and	CC
cord-023439-r04y1j22	652	10	could	could	MD
cord-023439-r04y1j22	652	11	play	play	VB
cord-023439-r04y1j22	652	12	a	a	DT
cord-023439-r04y1j22	652	13	role	role	NN
cord-023439-r04y1j22	652	14	for	for	IN
cord-023439-r04y1j22	652	15	the	the	DT
cord-023439-r04y1j22	652	16	development	development	NN
cord-023439-r04y1j22	652	17	of	of	IN
cord-023439-r04y1j22	652	18	immunological	immunological	JJ
cord-023439-r04y1j22	652	19	diseases	disease	NNS
cord-023439-r04y1j22	652	20	.	.	.
cord-023439-r04y1j22	653	1	Besides	besides	RB
cord-023439-r04y1j22	653	2	,	,	,
cord-023439-r04y1j22	653	3	it	-PRON-	PRP
cord-023439-r04y1j22	653	4	would	would	MD
cord-023439-r04y1j22	653	5	be	be	VB
cord-023439-r04y1j22	653	6	interesting	interesting	JJ
cord-023439-r04y1j22	653	7	to	to	TO
cord-023439-r04y1j22	653	8	see	see	VB
cord-023439-r04y1j22	653	9	whether	whether	IN
cord-023439-r04y1j22	653	10	both	both	DT
cord-023439-r04y1j22	653	11	exon	exon	NN
cord-023439-r04y1j22	653	12	3	3	CD
cord-023439-r04y1j22	653	13	alleles	allele	NNS
cord-023439-r04y1j22	653	14	are	be	VBP
cord-023439-r04y1j22	653	15	expressed	express	VBN
cord-023439-r04y1j22	653	16	or	or	CC
cord-023439-r04y1j22	653	17	only	only	RB
cord-023439-r04y1j22	653	18	the	the	DT
cord-023439-r04y1j22	653	19	wildtype	wildtype	JJ
cord-023439-r04y1j22	653	20	allele	allele	NN
cord-023439-r04y1j22	653	21	is	be	VBZ
cord-023439-r04y1j22	653	22	functional	functional	JJ
cord-023439-r04y1j22	653	23	.	.	.
cord-023439-r04y1j22	654	1	Interferon	interferon	NN
cord-023439-r04y1j22	654	2	-	-	HYPH
cord-023439-r04y1j22	654	3	a	a	NN
cord-023439-r04y1j22	654	4	/	/	SYM
cord-023439-r04y1j22	654	5	b	b	NN
cord-023439-r04y1j22	654	6	(	(	-LRB-
cord-023439-r04y1j22	654	7	IFN	IFN	NNP
cord-023439-r04y1j22	654	8	-	-	HYPH
cord-023439-r04y1j22	654	9	a	a	NNP
cord-023439-r04y1j22	654	10	/	/	SYM
cord-023439-r04y1j22	654	11	b	b	NN
cord-023439-r04y1j22	654	12	)	)	-RRB-
cord-023439-r04y1j22	654	13	is	be	VBZ
cord-023439-r04y1j22	654	14	increasingly	increasingly	RB
cord-023439-r04y1j22	654	15	used	use	VBN
cord-023439-r04y1j22	654	16	as	as	IN
cord-023439-r04y1j22	654	17	antiviral	antiviral	JJ
cord-023439-r04y1j22	654	18	and	and	CC
cord-023439-r04y1j22	654	19	immunomodulatory	immunomodulatory	JJ
cord-023439-r04y1j22	654	20	therapies	therapy	NNS
cord-023439-r04y1j22	654	21	.	.	.
cord-023439-r04y1j22	655	1	Unfortunately	unfortunately	RB
cord-023439-r04y1j22	655	2	,	,	,
cord-023439-r04y1j22	655	3	bioavailability	bioavailability	NN
cord-023439-r04y1j22	655	4	varies	vary	VBZ
cord-023439-r04y1j22	655	5	with	with	IN
cord-023439-r04y1j22	655	6	IFN	IFN	NNP
cord-023439-r04y1j22	655	7	species	specie	NNS
cord-023439-r04y1j22	655	8	and	and	CC
cord-023439-r04y1j22	655	9	mode	mode	NN
cord-023439-r04y1j22	655	10	of	of	IN
cord-023439-r04y1j22	655	11	administration	administration	NN
cord-023439-r04y1j22	655	12	,	,	,
cord-023439-r04y1j22	655	13	and	and	CC
cord-023439-r04y1j22	655	14	all	all	DT
cord-023439-r04y1j22	655	15	IFN	IFN	NNP
cord-023439-r04y1j22	655	16	species	specie	NNS
cord-023439-r04y1j22	655	17	are	be	VBP
cord-023439-r04y1j22	655	18	potentially	potentially	RB
cord-023439-r04y1j22	655	19	immunogenic	immunogenic	JJ
cord-023439-r04y1j22	655	20	.	.	.
cord-023439-r04y1j22	656	1	Assays	assay	NNS
cord-023439-r04y1j22	656	2	for	for	IN
cord-023439-r04y1j22	656	3	antiviral	antiviral	JJ
cord-023439-r04y1j22	656	4	activity	activity	NN
cord-023439-r04y1j22	656	5	(	(	-LRB-
cord-023439-r04y1j22	656	6	IFN	IFN	NNP
cord-023439-r04y1j22	656	7	)	)	-RRB-
cord-023439-r04y1j22	656	8	and	and	CC
cord-023439-r04y1j22	656	9	antiviral	antiviral	JJ
cord-023439-r04y1j22	656	10	neutralization	neutralization	NN
cord-023439-r04y1j22	656	11	(	(	-LRB-
cord-023439-r04y1j22	656	12	antibodies	antibody	NNS
cord-023439-r04y1j22	656	13	,	,	,
cord-023439-r04y1j22	656	14	NAb	NAb	NNS
cord-023439-r04y1j22	656	15	)	)	-RRB-
cord-023439-r04y1j22	656	16	have	have	VBP
cord-023439-r04y1j22	656	17	been	be	VBN
cord-023439-r04y1j22	656	18	used	use	VBN
cord-023439-r04y1j22	656	19	for	for	IN
cord-023439-r04y1j22	656	20	some	some	DT
cord-023439-r04y1j22	656	21	time	time	NN
cord-023439-r04y1j22	656	22	to	to	TO
cord-023439-r04y1j22	656	23	monitor	monitor	VB
cord-023439-r04y1j22	656	24	patients	patient	NNS
cord-023439-r04y1j22	656	25	on	on	IN
cord-023439-r04y1j22	656	26	IFN	IFN	NNP
cord-023439-r04y1j22	656	27	biologicals	biological	NNS
cord-023439-r04y1j22	656	28	.	.	.
cord-023439-r04y1j22	657	1	These	these	DT
cord-023439-r04y1j22	657	2	assays	assay	NNS
cord-023439-r04y1j22	657	3	require	require	VBP
cord-023439-r04y1j22	657	4	laborious	laborious	JJ
cord-023439-r04y1j22	657	5	titrations	titration	NNS
cord-023439-r04y1j22	657	6	making	make	VBG
cord-023439-r04y1j22	657	7	them	-PRON-	PRP
cord-023439-r04y1j22	657	8	unsuitable	unsuitable	JJ
cord-023439-r04y1j22	657	9	for	for	IN
cord-023439-r04y1j22	657	10	large	large	JJ
cord-023439-r04y1j22	657	11	-	-	HYPH
cord-023439-r04y1j22	657	12	scale	scale	NN
cord-023439-r04y1j22	657	13	clinical	clinical	JJ
cord-023439-r04y1j22	657	14	use	use	NN
cord-023439-r04y1j22	657	15	.	.	.
cord-023439-r04y1j22	658	1	Myxovirus	Myxovirus	NNP
cord-023439-r04y1j22	658	2	A	A	NNP
cord-023439-r04y1j22	658	3	(	(	-LRB-
cord-023439-r04y1j22	658	4	MxA	mxa	NN
cord-023439-r04y1j22	658	5	)	)	-RRB-
cord-023439-r04y1j22	658	6	is	be	VBZ
cord-023439-r04y1j22	658	7	a	a	DT
cord-023439-r04y1j22	658	8	resistance	resistance	NN
cord-023439-r04y1j22	658	9	GTPbinding	gtpbinding	NN
cord-023439-r04y1j22	658	10	protein	protein	NN
cord-023439-r04y1j22	658	11	that	that	WDT
cord-023439-r04y1j22	658	12	is	be	VBZ
cord-023439-r04y1j22	658	13	specifically	specifically	RB
cord-023439-r04y1j22	658	14	induced	induce	VBN
cord-023439-r04y1j22	658	15	by	by	IN
cord-023439-r04y1j22	658	16	treatment	treatment	NN
cord-023439-r04y1j22	658	17	with	with	IN
cord-023439-r04y1j22	658	18	type	type	NN
cord-023439-r04y1j22	658	19	1	1	CD
cord-023439-r04y1j22	658	20	IFNs	ifn	NNS
cord-023439-r04y1j22	658	21	.	.	.
cord-023439-r04y1j22	659	1	For	for	IN
cord-023439-r04y1j22	659	2	example	example	NN
cord-023439-r04y1j22	659	3	,	,	,
cord-023439-r04y1j22	659	4	IFN	IFN	NNP
cord-023439-r04y1j22	659	5	-	-	HYPH
cord-023439-r04y1j22	659	6	b	b	NNP
cord-023439-r04y1j22	659	7	-	-	HYPH
cord-023439-r04y1j22	659	8	induced	induce	VBN
cord-023439-r04y1j22	659	9	MxA	mxa	NN
cord-023439-r04y1j22	659	10	in	in	IN
cord-023439-r04y1j22	659	11	blood	blood	NN
cord-023439-r04y1j22	659	12	leucocytes	leucocyte	NNS
cord-023439-r04y1j22	659	13	has	have	VBZ
cord-023439-r04y1j22	659	14	been	be	VBN
cord-023439-r04y1j22	659	15	used	use	VBN
cord-023439-r04y1j22	659	16	as	as	IN
cord-023439-r04y1j22	659	17	a	a	DT
cord-023439-r04y1j22	659	18	biomarker	biomarker	NN
cord-023439-r04y1j22	659	19	in	in	IN
cord-023439-r04y1j22	659	20	IFN	IFN	NNP
cord-023439-r04y1j22	659	21	-	-	HYPH
cord-023439-r04y1j22	659	22	btreated	btreate	VBN
cord-023439-r04y1j22	659	23	patients	patient	NNS
cord-023439-r04y1j22	659	24	with	with	IN
cord-023439-r04y1j22	659	25	multiple	multiple	JJ
cord-023439-r04y1j22	659	26	sclerosis	sclerosis	NN
cord-023439-r04y1j22	659	27	.	.	.
cord-023439-r04y1j22	660	1	However	however	RB
cord-023439-r04y1j22	660	2	,	,	,
cord-023439-r04y1j22	660	3	the	the	DT
cord-023439-r04y1j22	660	4	degree	degree	NN
cord-023439-r04y1j22	660	5	of	of	IN
cord-023439-r04y1j22	660	6	specificity	specificity	NN
cord-023439-r04y1j22	660	7	of	of	IN
cord-023439-r04y1j22	660	8	MxA	mxa	NN
cord-023439-r04y1j22	660	9	in	in	IN
cord-023439-r04y1j22	660	10	this	this	DT
cord-023439-r04y1j22	660	11	regard	regard	NN
cord-023439-r04y1j22	660	12	is	be	VBZ
cord-023439-r04y1j22	660	13	unclear	unclear	JJ
cord-023439-r04y1j22	660	14	,	,	,
cord-023439-r04y1j22	660	15	and	and	CC
cord-023439-r04y1j22	660	16	measurements	measurement	NNS
cord-023439-r04y1j22	660	17	of	of	IN
cord-023439-r04y1j22	660	18	MxA	mxa	NN
cord-023439-r04y1j22	660	19	protein	protein	NN
cord-023439-r04y1j22	660	20	and/or	and/or	CC
cord-023439-r04y1j22	661	1	mRNA	mrna	NN
cord-023439-r04y1j22	661	2	are	be	VBP
cord-023439-r04y1j22	661	3	not	not	RB
cord-023439-r04y1j22	661	4	yet	yet	RB
cord-023439-r04y1j22	661	5	suitable	suitable	JJ
cord-023439-r04y1j22	661	6	for	for	IN
cord-023439-r04y1j22	661	7	routine	routine	JJ
cord-023439-r04y1j22	661	8	clinical	clinical	JJ
cord-023439-r04y1j22	661	9	use	use	NN
cord-023439-r04y1j22	661	10	.	.	.
cord-023439-r04y1j22	662	1	In	in	IN
cord-023439-r04y1j22	662	2	an	an	DT
cord-023439-r04y1j22	662	3	attempt	attempt	NN
cord-023439-r04y1j22	662	4	to	to	TO
cord-023439-r04y1j22	662	5	find	find	VB
cord-023439-r04y1j22	662	6	new	new	JJ
cord-023439-r04y1j22	662	7	and	and	CC
cord-023439-r04y1j22	662	8	better	well	JJR
cord-023439-r04y1j22	662	9	reporter	reporter	NN
cord-023439-r04y1j22	662	10	genes	gene	NNS
cord-023439-r04y1j22	662	11	(	(	-LRB-
cord-023439-r04y1j22	662	12	and	and	CC
cord-023439-r04y1j22	662	13	,	,	,
cord-023439-r04y1j22	662	14	hopefully	hopefully	RB
cord-023439-r04y1j22	662	15	,	,	,
cord-023439-r04y1j22	662	16	genes	gene	NNS
cord-023439-r04y1j22	662	17	and	and	CC
cord-023439-r04y1j22	662	18	gene	gene	NN
cord-023439-r04y1j22	662	19	products	product	NNS
cord-023439-r04y1j22	662	20	with	with	IN
cord-023439-r04y1j22	662	21	proven	prove	VBN
cord-023439-r04y1j22	662	22	specificity	specificity	NN
cord-023439-r04y1j22	662	23	for	for	IN
cord-023439-r04y1j22	662	24	IFN	IFN	NNP
cord-023439-r04y1j22	662	25	-	-	:
cord-023439-r04y1j22	662	26	a	a	NN
cord-023439-r04y1j22	662	27	and	and	CC
cord-023439-r04y1j22	662	28	-b	-b	SYM
cord-023439-r04y1j22	662	29	)	)	-RRB-
cord-023439-r04y1j22	662	30	,	,	,
cord-023439-r04y1j22	662	31	microarray	microarray	NN
cord-023439-r04y1j22	662	32	screenings	screening	NNS
cord-023439-r04y1j22	662	33	with	with	IN
cord-023439-r04y1j22	662	34	U133A	U133A	NNP
cord-023439-r04y1j22	662	35	GeneChips	GeneChips	NNP
cord-023439-r04y1j22	662	36	(	(	-LRB-
cord-023439-r04y1j22	662	37	Affymetrix	Affymetrix	NNP
cord-023439-r04y1j22	662	38	)	)	-RRB-
cord-023439-r04y1j22	662	39	were	be	VBD
cord-023439-r04y1j22	662	40	carried	carry	VBN
cord-023439-r04y1j22	662	41	using	use	VBG
cord-023439-r04y1j22	662	42	human	human	JJ
cord-023439-r04y1j22	662	43	blood	blood	NN
cord-023439-r04y1j22	662	44	leucocytes	leucocyte	NNS
cord-023439-r04y1j22	662	45	and	and	CC
cord-023439-r04y1j22	662	46	the	the	DT
cord-023439-r04y1j22	662	47	human	human	JJ
cord-023439-r04y1j22	662	48	lung	lung	NN
cord-023439-r04y1j22	662	49	carcinoma	carcinoma	NN
cord-023439-r04y1j22	662	50	cell	cell	NN
cord-023439-r04y1j22	662	51	line	line	NN
cord-023439-r04y1j22	662	52	A549	a549	JJ
cord-023439-r04y1j22	662	53	.	.	.
cord-023439-r04y1j22	663	1	We	-PRON-	PRP
cord-023439-r04y1j22	663	2	studied	study	VBD
cord-023439-r04y1j22	663	3	the	the	DT
cord-023439-r04y1j22	663	4	simultaneous	simultaneous	JJ
cord-023439-r04y1j22	663	5	expression	expression	NN
cord-023439-r04y1j22	663	6	of	of	IN
cord-023439-r04y1j22	663	7	22,000	22,000	CD
cord-023439-r04y1j22	663	8	transcripts	transcript	NNS
cord-023439-r04y1j22	663	9	before	before	IN
cord-023439-r04y1j22	663	10	and	and	CC
cord-023439-r04y1j22	663	11	after	after	IN
cord-023439-r04y1j22	663	12	exposure	exposure	NN
cord-023439-r04y1j22	663	13	to	to	IN
cord-023439-r04y1j22	663	14	human	human	JJ
cord-023439-r04y1j22	663	15	recombinant	recombinant	JJ
cord-023439-r04y1j22	663	16	IFN	IFN	NNP
cord-023439-r04y1j22	663	17	-	-	HYPH
cord-023439-r04y1j22	663	18	a	a	NNP
cord-023439-r04y1j22	663	19	and	and	CC
cord-023439-r04y1j22	663	20	IFN	IFN	NNP
cord-023439-r04y1j22	663	21	-	-	HYPH
cord-023439-r04y1j22	663	22	b	b	NNP
cord-023439-r04y1j22	663	23	and	and	CC
cord-023439-r04y1j22	663	24	other	other	JJ
cord-023439-r04y1j22	663	25	antiviral	antiviral	JJ
cord-023439-r04y1j22	663	26	and	and	CC
cord-023439-r04y1j22	663	27	immunomodulatory	immunomodulatory	JJ
cord-023439-r04y1j22	663	28	cytokines	cytokine	NNS
cord-023439-r04y1j22	663	29	.	.	.
cord-023439-r04y1j22	664	1	The	the	DT
cord-023439-r04y1j22	664	2	results	result	NNS
cord-023439-r04y1j22	664	3	will	will	MD
cord-023439-r04y1j22	664	4	be	be	VB
cord-023439-r04y1j22	664	5	presented	present	VBN
cord-023439-r04y1j22	664	6	at	at	IN
cord-023439-r04y1j22	664	7	the	the	DT
cord-023439-r04y1j22	664	8	conference	conference	NN
cord-023439-r04y1j22	664	9	.	.	.
cord-023439-r04y1j22	665	1	Interferon	interferon	NN
cord-023439-r04y1j22	665	2	-	-	HYPH
cord-023439-r04y1j22	665	3	a	a	NN
cord-023439-r04y1j22	665	4	/	/	SYM
cord-023439-r04y1j22	665	5	b	b	NN
cord-023439-r04y1j22	665	6	(	(	-LRB-
cord-023439-r04y1j22	665	7	IFN	IFN	NNP
cord-023439-r04y1j22	665	8	-	-	HYPH
cord-023439-r04y1j22	665	9	a	a	NNP
cord-023439-r04y1j22	665	10	/	/	SYM
cord-023439-r04y1j22	665	11	b	b	NN
cord-023439-r04y1j22	665	12	)	)	-RRB-
cord-023439-r04y1j22	665	13	is	be	VBZ
cord-023439-r04y1j22	665	14	increasingly	increasingly	RB
cord-023439-r04y1j22	665	15	used	use	VBN
cord-023439-r04y1j22	665	16	as	as	IN
cord-023439-r04y1j22	665	17	antiviral	antiviral	JJ
cord-023439-r04y1j22	665	18	and	and	CC
cord-023439-r04y1j22	665	19	immunomodulatory	immunomodulatory	JJ
cord-023439-r04y1j22	665	20	therapies	therapy	NNS
cord-023439-r04y1j22	665	21	.	.	.
cord-023439-r04y1j22	666	1	Unfortunately	unfortunately	RB
cord-023439-r04y1j22	666	2	,	,	,
cord-023439-r04y1j22	666	3	bioavailability	bioavailability	NN
cord-023439-r04y1j22	666	4	varies	vary	VBZ
cord-023439-r04y1j22	666	5	with	with	IN
cord-023439-r04y1j22	666	6	IFN	IFN	NNP
cord-023439-r04y1j22	666	7	species	specie	NNS
cord-023439-r04y1j22	666	8	and	and	CC
cord-023439-r04y1j22	666	9	mode	mode	NN
cord-023439-r04y1j22	666	10	of	of	IN
cord-023439-r04y1j22	666	11	administration	administration	NN
cord-023439-r04y1j22	666	12	,	,	,
cord-023439-r04y1j22	666	13	and	and	CC
cord-023439-r04y1j22	666	14	all	all	DT
cord-023439-r04y1j22	666	15	IFN	IFN	NNP
cord-023439-r04y1j22	666	16	species	specie	NNS
cord-023439-r04y1j22	666	17	are	be	VBP
cord-023439-r04y1j22	666	18	potentially	potentially	RB
cord-023439-r04y1j22	666	19	immunogenic	immunogenic	JJ
cord-023439-r04y1j22	666	20	.	.	.
cord-023439-r04y1j22	667	1	Assays	assay	NNS
cord-023439-r04y1j22	667	2	for	for	IN
cord-023439-r04y1j22	667	3	antiviral	antiviral	JJ
cord-023439-r04y1j22	667	4	activity	activity	NN
cord-023439-r04y1j22	667	5	(	(	-LRB-
cord-023439-r04y1j22	667	6	IFN	IFN	NNP
cord-023439-r04y1j22	667	7	)	)	-RRB-
cord-023439-r04y1j22	667	8	and	and	CC
cord-023439-r04y1j22	667	9	antiviral	antiviral	JJ
cord-023439-r04y1j22	667	10	neutralization	neutralization	NN
cord-023439-r04y1j22	667	11	(	(	-LRB-
cord-023439-r04y1j22	667	12	antibodies	antibody	NNS
cord-023439-r04y1j22	667	13	,	,	,
cord-023439-r04y1j22	667	14	NAb	NAb	NNS
cord-023439-r04y1j22	667	15	)	)	-RRB-
cord-023439-r04y1j22	667	16	have	have	VBP
cord-023439-r04y1j22	667	17	been	be	VBN
cord-023439-r04y1j22	667	18	used	use	VBN
cord-023439-r04y1j22	667	19	for	for	IN
cord-023439-r04y1j22	667	20	some	some	DT
cord-023439-r04y1j22	667	21	time	time	NN
cord-023439-r04y1j22	667	22	to	to	TO
cord-023439-r04y1j22	667	23	monitor	monitor	VB
cord-023439-r04y1j22	667	24	patients	patient	NNS
cord-023439-r04y1j22	667	25	on	on	IN
cord-023439-r04y1j22	667	26	IFN	IFN	NNP
cord-023439-r04y1j22	667	27	biologicals	biological	NNS
cord-023439-r04y1j22	667	28	.	.	.
cord-023439-r04y1j22	668	1	These	these	DT
cord-023439-r04y1j22	668	2	assays	assay	NNS
cord-023439-r04y1j22	668	3	require	require	VBP
cord-023439-r04y1j22	668	4	laborious	laborious	JJ
cord-023439-r04y1j22	668	5	titrations	titration	NNS
cord-023439-r04y1j22	668	6	making	make	VBG
cord-023439-r04y1j22	668	7	them	-PRON-	PRP
cord-023439-r04y1j22	668	8	unsuitable	unsuitable	JJ
cord-023439-r04y1j22	668	9	for	for	IN
cord-023439-r04y1j22	668	10	large	large	JJ
cord-023439-r04y1j22	668	11	-	-	HYPH
cord-023439-r04y1j22	668	12	scale	scale	NN
cord-023439-r04y1j22	668	13	clinical	clinical	JJ
cord-023439-r04y1j22	668	14	use	use	NN
cord-023439-r04y1j22	668	15	.	.	.
cord-023439-r04y1j22	669	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	669	2	laboratories	laboratory	NNS
cord-023439-r04y1j22	669	3	have	have	VBP
cord-023439-r04y1j22	669	4	therefore	therefore	RB
cord-023439-r04y1j22	669	5	modified	modify	VBN
cord-023439-r04y1j22	669	6	the	the	DT
cord-023439-r04y1j22	669	7	antiviral	antiviral	JJ
cord-023439-r04y1j22	669	8	assays	assay	NNS
cord-023439-r04y1j22	669	9	for	for	IN
cord-023439-r04y1j22	669	10	IFN	IFN	NNP
cord-023439-r04y1j22	669	11	bioactivity	bioactivity	NNP
cord-023439-r04y1j22	669	12	and	and	CC
cord-023439-r04y1j22	669	13	Nab	Nab	NNP
cord-023439-r04y1j22	669	14	,	,	,
cord-023439-r04y1j22	669	15	so	so	IN
cord-023439-r04y1j22	669	16	that	that	IN
cord-023439-r04y1j22	669	17	they	-PRON-	PRP
cord-023439-r04y1j22	669	18	are	be	VBP
cord-023439-r04y1j22	669	19	suitable	suitable	JJ
cord-023439-r04y1j22	669	20	for	for	IN
cord-023439-r04y1j22	669	21	large	large	JJ
cord-023439-r04y1j22	669	22	-	-	HYPH
cord-023439-r04y1j22	669	23	scale	scale	NN
cord-023439-r04y1j22	669	24	screening	screening	NN
cord-023439-r04y1j22	669	25	in	in	IN
cord-023439-r04y1j22	669	26	specialized	specialized	JJ
cord-023439-r04y1j22	669	27	laboratories	laboratory	NNS
cord-023439-r04y1j22	669	28	.	.	.
cord-023439-r04y1j22	670	1	The	the	DT
cord-023439-r04y1j22	670	2	read	read	NN
cord-023439-r04y1j22	670	3	-	-	HYPH
cord-023439-r04y1j22	670	4	out	out	NN
cord-023439-r04y1j22	670	5	is	be	VBZ
cord-023439-r04y1j22	670	6	survival	survival	NN
cord-023439-r04y1j22	670	7	of	of	IN
cord-023439-r04y1j22	670	8	a	a	DT
cord-023439-r04y1j22	670	9	subcloned	subcloned	JJ
cord-023439-r04y1j22	670	10	A549	a549	JJ
cord-023439-r04y1j22	670	11	cell	cell	NN
cord-023439-r04y1j22	670	12	line	line	NN
cord-023439-r04y1j22	670	13	in	in	IN
cord-023439-r04y1j22	670	14	the	the	DT
cord-023439-r04y1j22	670	15	presence	presence	NN
cord-023439-r04y1j22	670	16	of	of	IN
cord-023439-r04y1j22	670	17	an	an	DT
cord-023439-r04y1j22	670	18	otherwise	otherwise	RB
cord-023439-r04y1j22	670	19	lethal	lethal	JJ
cord-023439-r04y1j22	670	20	amount	amount	NN
cord-023439-r04y1j22	670	21	of	of	IN
cord-023439-r04y1j22	670	22	virus	virus	NN
cord-023439-r04y1j22	670	23	.	.	.
cord-023439-r04y1j22	671	1	Thus	thus	RB
cord-023439-r04y1j22	671	2	,	,	,
cord-023439-r04y1j22	671	3	survival	survival	NN
cord-023439-r04y1j22	671	4	increases	increase	NNS
cord-023439-r04y1j22	671	5	in	in	IN
cord-023439-r04y1j22	671	6	the	the	DT
cord-023439-r04y1j22	671	7	presence	presence	NN
cord-023439-r04y1j22	671	8	of	of	IN
cord-023439-r04y1j22	671	9	type	type	NN
cord-023439-r04y1j22	671	10	1	1	CD
cord-023439-r04y1j22	671	11	IFN	IFN	NNP
cord-023439-r04y1j22	671	12	and	and	CC
cord-023439-r04y1j22	671	13	decreases	decrease	VBZ
cord-023439-r04y1j22	671	14	in	in	IN
cord-023439-r04y1j22	671	15	the	the	DT
cord-023439-r04y1j22	671	16	presence	presence	NN
cord-023439-r04y1j22	671	17	of	of	IN
cord-023439-r04y1j22	671	18	NAb	NAb	NNS
cord-023439-r04y1j22	671	19	against	against	IN
cord-023439-r04y1j22	671	20	the	the	DT
cord-023439-r04y1j22	671	21	IFN	IFN	NNP
cord-023439-r04y1j22	671	22	added	add	VBD
cord-023439-r04y1j22	671	23	to	to	IN
cord-023439-r04y1j22	671	24	the	the	DT
cord-023439-r04y1j22	671	25	cells	cell	NNS
cord-023439-r04y1j22	671	26	.	.	.
cord-023439-r04y1j22	672	1	MxA	MxA	NNP
cord-023439-r04y1j22	672	2	is	be	VBZ
cord-023439-r04y1j22	672	3	induced	induce	VBN
cord-023439-r04y1j22	672	4	by	by	IN
cord-023439-r04y1j22	672	5	type	type	NN
cord-023439-r04y1j22	672	6	1	1	CD
cord-023439-r04y1j22	672	7	IFN	IFN	NNP
cord-023439-r04y1j22	672	8	and	and	CC
cord-023439-r04y1j22	672	9	can	can	MD
cord-023439-r04y1j22	672	10	be	be	VB
cord-023439-r04y1j22	672	11	used	use	VBN
cord-023439-r04y1j22	672	12	for	for	IN
cord-023439-r04y1j22	672	13	measuring	measure	VBG
cord-023439-r04y1j22	672	14	the	the	DT
cord-023439-r04y1j22	672	15	Nab	Nab	NNP
cord-023439-r04y1j22	672	16	activity	activity	NN
cord-023439-r04y1j22	672	17	.	.	.
cord-023439-r04y1j22	673	1	In	in	IN
cord-023439-r04y1j22	673	2	another	another	DT
cord-023439-r04y1j22	673	3	assay	assay	NN
cord-023439-r04y1j22	673	4	,	,	,
cord-023439-r04y1j22	673	5	the	the	DT
cord-023439-r04y1j22	673	6	MxA	mxa	NN
cord-023439-r04y1j22	673	7	level	level	NN
cord-023439-r04y1j22	673	8	in	in	IN
cord-023439-r04y1j22	673	9	the	the	DT
cord-023439-r04y1j22	673	10	A549	a549	JJ
cord-023439-r04y1j22	673	11	cell	cell	NN
cord-023439-r04y1j22	673	12	line	line	NN
cord-023439-r04y1j22	673	13	is	be	VBZ
cord-023439-r04y1j22	673	14	measured	measure	VBN
cord-023439-r04y1j22	673	15	.	.	.
cord-023439-r04y1j22	674	1	In	in	IN
cord-023439-r04y1j22	674	2	an	an	DT
cord-023439-r04y1j22	674	3	attempt	attempt	NN
cord-023439-r04y1j22	674	4	to	to	TO
cord-023439-r04y1j22	674	5	find	find	VB
cord-023439-r04y1j22	674	6	a	a	DT
cord-023439-r04y1j22	674	7	new	new	JJ
cord-023439-r04y1j22	674	8	and	and	CC
cord-023439-r04y1j22	674	9	better	well	JJR
cord-023439-r04y1j22	674	10	reporter	reporter	NN
cord-023439-r04y1j22	674	11	gene	gene	NN
cord-023439-r04y1j22	674	12	for	for	IN
cord-023439-r04y1j22	674	13	type	type	NN
cord-023439-r04y1j22	674	14	1	1	CD
cord-023439-r04y1j22	674	15	IFN	IFN	NNP
cord-023439-r04y1j22	674	16	than	than	IN
cord-023439-r04y1j22	674	17	MxA	mxa	NN
cord-023439-r04y1j22	674	18	and	and	CC
cord-023439-r04y1j22	674	19	genes	gene	NNS
cord-023439-r04y1j22	674	20	specific	specific	JJ
cord-023439-r04y1j22	674	21	for	for	IN
cord-023439-r04y1j22	674	22	either	either	CC
cord-023439-r04y1j22	674	23	IFN	IFN	NNP
cord-023439-r04y1j22	674	24	-	-	HYPH
cord-023439-r04y1j22	674	25	a	a	NN
cord-023439-r04y1j22	674	26	or	or	CC
cord-023439-r04y1j22	674	27	-b	-b	SYM
cord-023439-r04y1j22	674	28	,	,	,
cord-023439-r04y1j22	674	29	a	a	DT
cord-023439-r04y1j22	674	30	micro	micro	JJ
cord-023439-r04y1j22	674	31	array	array	NN
cord-023439-r04y1j22	674	32	screen	screen	NN
cord-023439-r04y1j22	674	33	was	be	VBD
cord-023439-r04y1j22	674	34	carried	carry	VBN
cord-023439-r04y1j22	674	35	using	use	VBG
cord-023439-r04y1j22	674	36	the	the	DT
cord-023439-r04y1j22	674	37	U133A	U133A	NNP
cord-023439-r04y1j22	674	38	chip	chip	NN
cord-023439-r04y1j22	674	39	from	from	IN
cord-023439-r04y1j22	674	40	Affymetrix	Affymetrix	NNP
cord-023439-r04y1j22	674	41	.	.	.
cord-023439-r04y1j22	675	1	The	the	DT
cord-023439-r04y1j22	675	2	expression	expression	NN
cord-023439-r04y1j22	675	3	of	of	IN
cord-023439-r04y1j22	675	4	22,000	22,000	CD
cord-023439-r04y1j22	675	5	genes	gene	NNS
cord-023439-r04y1j22	675	6	can	can	MD
cord-023439-r04y1j22	675	7	be	be	VB
cord-023439-r04y1j22	675	8	studied	study	VBN
cord-023439-r04y1j22	675	9	simultaneous	simultaneous	JJ
cord-023439-r04y1j22	675	10	with	with	IN
cord-023439-r04y1j22	675	11	this	this	DT
cord-023439-r04y1j22	675	12	technology	technology	NN
cord-023439-r04y1j22	675	13	.	.	.
cord-023439-r04y1j22	676	1	The	the	DT
cord-023439-r04y1j22	676	2	results	result	NNS
cord-023439-r04y1j22	676	3	will	will	MD
cord-023439-r04y1j22	676	4	be	be	VB
cord-023439-r04y1j22	676	5	presented	present	VBN
cord-023439-r04y1j22	676	6	at	at	IN
cord-023439-r04y1j22	676	7	the	the	DT
cord-023439-r04y1j22	676	8	conference	conference	NN
cord-023439-r04y1j22	676	9	.	.	.
cord-023439-r04y1j22	677	1	In	in	IN
cord-023439-r04y1j22	677	2	our	-PRON-	PRP$
cord-023439-r04y1j22	677	3	laboratory	laboratory	NN
cord-023439-r04y1j22	677	4	,	,	,
cord-023439-r04y1j22	677	5	we	-PRON-	PRP
cord-023439-r04y1j22	677	6	have	have	VBP
cord-023439-r04y1j22	677	7	developed	develop	VBN
cord-023439-r04y1j22	677	8	a	a	DT
cord-023439-r04y1j22	677	9	database	database	NN
cord-023439-r04y1j22	677	10	system	system	NN
cord-023439-r04y1j22	677	11	,	,	,
cord-023439-r04y1j22	677	12	which	which	WDT
cord-023439-r04y1j22	677	13	we	-PRON-	PRP
cord-023439-r04y1j22	677	14	believe	believe	VBP
cord-023439-r04y1j22	677	15	is	be	VBZ
cord-023439-r04y1j22	677	16	of	of	IN
cord-023439-r04y1j22	677	17	immediate	immediate	JJ
cord-023439-r04y1j22	677	18	interest	interest	NN
cord-023439-r04y1j22	677	19	to	to	IN
cord-023439-r04y1j22	677	20	the	the	DT
cord-023439-r04y1j22	677	21	general	general	JJ
cord-023439-r04y1j22	677	22	scientific	scientific	JJ
cord-023439-r04y1j22	677	23	community	community	NN
cord-023439-r04y1j22	677	24	.	.	.
cord-023439-r04y1j22	678	1	The	the	DT
cord-023439-r04y1j22	678	2	database	database	NN
cord-023439-r04y1j22	678	3	represents	represent	VBZ
cord-023439-r04y1j22	678	4	a	a	DT
cord-023439-r04y1j22	678	5	computerbased	computerbased	JJ
cord-023439-r04y1j22	678	6	replacement	replacement	NN
cord-023439-r04y1j22	678	7	for	for	IN
cord-023439-r04y1j22	678	8	the	the	DT
cord-023439-r04y1j22	678	9	laboratory	laboratory	NN
cord-023439-r04y1j22	678	10	notebooks	notebook	NNS
cord-023439-r04y1j22	678	11	used	use	VBN
cord-023439-r04y1j22	678	12	in	in	IN
cord-023439-r04y1j22	678	13	the	the	DT
cord-023439-r04y1j22	678	14	majority	majority	NN
cord-023439-r04y1j22	678	15	of	of	IN
cord-023439-r04y1j22	678	16	research	research	NN
cord-023439-r04y1j22	678	17	laboratories	laboratory	NNS
cord-023439-r04y1j22	678	18	worldwide	worldwide	RB
cord-023439-r04y1j22	678	19	.	.	.
cord-023439-r04y1j22	679	1	In	in	IN
cord-023439-r04y1j22	679	2	addition	addition	NN
cord-023439-r04y1j22	679	3	,	,	,
cord-023439-r04y1j22	679	4	the	the	DT
cord-023439-r04y1j22	679	5	database	database	NN
cord-023439-r04y1j22	679	6	provides	provide	VBZ
cord-023439-r04y1j22	679	7	an	an	DT
cord-023439-r04y1j22	679	8	effective	effective	JJ
cord-023439-r04y1j22	679	9	tool	tool	NN
cord-023439-r04y1j22	679	10	for	for	IN
cord-023439-r04y1j22	679	11	organizing	organize	VBG
cord-023439-r04y1j22	679	12	and	and	CC
cord-023439-r04y1j22	679	13	managing	manage	VBG
cord-023439-r04y1j22	679	14	laboratory	laboratory	NN
cord-023439-r04y1j22	679	15	information	information	NN
cord-023439-r04y1j22	679	16	at	at	IN
cord-023439-r04y1j22	679	17	all	all	DT
cord-023439-r04y1j22	679	18	levels	level	NNS
cord-023439-r04y1j22	679	19	,	,	,
cord-023439-r04y1j22	679	20	spanning	span	VBG
cord-023439-r04y1j22	679	21	from	from	IN
cord-023439-r04y1j22	679	22	managing	manage	VBG
cord-023439-r04y1j22	679	23	and	and	CC
cord-023439-r04y1j22	679	24	revising	revise	VBG
cord-023439-r04y1j22	679	25	standard	standard	JJ
cord-023439-r04y1j22	679	26	operating	operate	VBG
cord-023439-r04y1j22	679	27	procedures	procedure	NNS
cord-023439-r04y1j22	679	28	and	and	CC
cord-023439-r04y1j22	679	29	producing	produce	VBG
cord-023439-r04y1j22	679	30	documentation	documentation	NN
cord-023439-r04y1j22	679	31	of	of	IN
cord-023439-r04y1j22	679	32	research	research	NN
cord-023439-r04y1j22	679	33	activities	activity	NNS
cord-023439-r04y1j22	679	34	to	to	IN
cord-023439-r04y1j22	679	35	keeping	keep	VBG
cord-023439-r04y1j22	679	36	track	track	NN
cord-023439-r04y1j22	679	37	of	of	IN
cord-023439-r04y1j22	679	38	data	datum	NNS
cord-023439-r04y1j22	679	39	and	and	CC
cord-023439-r04y1j22	679	40	conclusions	conclusion	NNS
cord-023439-r04y1j22	679	41	.	.	.
cord-023439-r04y1j22	680	1	Using	use	VBG
cord-023439-r04y1j22	680	2	the	the	DT
cord-023439-r04y1j22	680	3	commercially	commercially	RB
cord-023439-r04y1j22	680	4	available	available	JJ
cord-023439-r04y1j22	680	5	database	database	NN
cord-023439-r04y1j22	680	6	toolkit	toolkit	NN
cord-023439-r04y1j22	680	7	software	software	NN
cord-023439-r04y1j22	680	8	FILEMAKER	FILEMAKER	NNP
cord-023439-r04y1j22	680	9	PRO	PRO	NNP
cord-023439-r04y1j22	680	10	,	,	,
cord-023439-r04y1j22	680	11	we	-PRON-	PRP
cord-023439-r04y1j22	680	12	have	have	VBP
cord-023439-r04y1j22	680	13	developed	develop	VBN
cord-023439-r04y1j22	680	14	a	a	DT
cord-023439-r04y1j22	680	15	relational	relational	JJ
cord-023439-r04y1j22	680	16	database	database	NN
cord-023439-r04y1j22	680	17	solution	solution	NN
cord-023439-r04y1j22	680	18	for	for	IN
cord-023439-r04y1j22	680	19	management	management	NN
cord-023439-r04y1j22	680	20	of	of	IN
cord-023439-r04y1j22	680	21	laboratory	laboratory	NN
cord-023439-r04y1j22	680	22	information	information	NN
cord-023439-r04y1j22	680	23	.	.	.
cord-023439-r04y1j22	681	1	The	the	DT
cord-023439-r04y1j22	681	2	system	system	NN
cord-023439-r04y1j22	681	3	consists	consist	VBZ
cord-023439-r04y1j22	681	4	of	of	IN
cord-023439-r04y1j22	681	5	a	a	DT
cord-023439-r04y1j22	681	6	hierarchy	hierarchy	NN
cord-023439-r04y1j22	681	7	of	of	IN
cord-023439-r04y1j22	681	8	five	five	CD
cord-023439-r04y1j22	681	9	interrelated	interrelated	JJ
cord-023439-r04y1j22	681	10	databases	database	NNS
cord-023439-r04y1j22	681	11	,	,	,
cord-023439-r04y1j22	681	12	each	each	DT
cord-023439-r04y1j22	681	13	pertaining	pertain	VBG
cord-023439-r04y1j22	681	14	to	to	IN
cord-023439-r04y1j22	681	15	a	a	DT
cord-023439-r04y1j22	681	16	separate	separate	JJ
cord-023439-r04y1j22	681	17	type	type	NN
cord-023439-r04y1j22	681	18	of	of	IN
cord-023439-r04y1j22	681	19	information	information	NN
cord-023439-r04y1j22	681	20	,	,	,
cord-023439-r04y1j22	681	21	namely	namely	RB
cord-023439-r04y1j22	681	22	,	,	,
cord-023439-r04y1j22	681	23	overall	overall	JJ
cord-023439-r04y1j22	681	24	project	project	NN
cord-023439-r04y1j22	681	25	information	information	NN
cord-023439-r04y1j22	681	26	,	,	,
cord-023439-r04y1j22	681	27	information	information	NN
cord-023439-r04y1j22	681	28	relating	relate	VBG
cord-023439-r04y1j22	681	29	to	to	IN
cord-023439-r04y1j22	681	30	individual	individual	JJ
cord-023439-r04y1j22	681	31	experiment	experiment	NN
cord-023439-r04y1j22	681	32	setups	setup	NNS
cord-023439-r04y1j22	681	33	,	,	,
cord-023439-r04y1j22	681	34	documentation	documentation	NN
cord-023439-r04y1j22	681	35	of	of	IN
cord-023439-r04y1j22	681	36	daily	daily	JJ
cord-023439-r04y1j22	681	37	research	research	NN
cord-023439-r04y1j22	681	38	activity	activity	NN
cord-023439-r04y1j22	681	39	,	,	,
cord-023439-r04y1j22	681	40	generated	generate	VBD
cord-023439-r04y1j22	681	41	data	datum	NNS
cord-023439-r04y1j22	681	42	and	and	CC
cord-023439-r04y1j22	681	43	descriptions	description	NNS
cord-023439-r04y1j22	681	44	of	of	IN
cord-023439-r04y1j22	681	45	standard	standard	JJ
cord-023439-r04y1j22	681	46	operating	operating	NN
cord-023439-r04y1j22	681	47	procedures	procedure	NNS
cord-023439-r04y1j22	681	48	.	.	.
cord-023439-r04y1j22	682	1	Like	like	IN
cord-023439-r04y1j22	682	2	other	other	JJ
cord-023439-r04y1j22	682	3	databases	database	NNS
cord-023439-r04y1j22	682	4	,	,	,
cord-023439-r04y1j22	682	5	each	each	DT
cord-023439-r04y1j22	682	6	individual	individual	JJ
cord-023439-r04y1j22	682	7	database	database	NN
cord-023439-r04y1j22	682	8	consists	consist	VBZ
cord-023439-r04y1j22	682	9	of	of	IN
cord-023439-r04y1j22	682	10	a	a	DT
cord-023439-r04y1j22	682	11	number	number	NN
cord-023439-r04y1j22	682	12	of	of	IN
cord-023439-r04y1j22	682	13	records	record	NNS
cord-023439-r04y1j22	682	14	,	,	,
cord-023439-r04y1j22	682	15	each	each	DT
cord-023439-r04y1j22	682	16	comprised	comprise	VBN
cord-023439-r04y1j22	682	17	of	of	IN
cord-023439-r04y1j22	682	18	a	a	DT
cord-023439-r04y1j22	682	19	set	set	NN
cord-023439-r04y1j22	682	20	of	of	IN
cord-023439-r04y1j22	682	21	fields	field	NNS
cord-023439-r04y1j22	682	22	in	in	IN
cord-023439-r04y1j22	682	23	which	which	WDT
cord-023439-r04y1j22	682	24	information	information	NN
cord-023439-r04y1j22	682	25	is	be	VBZ
cord-023439-r04y1j22	682	26	entered	enter	VBN
cord-023439-r04y1j22	682	27	.	.	.
cord-023439-r04y1j22	683	1	In	in	IN
cord-023439-r04y1j22	683	2	each	each	DT
cord-023439-r04y1j22	683	3	record	record	NN
cord-023439-r04y1j22	683	4	,	,	,
cord-023439-r04y1j22	683	5	a	a	DT
cord-023439-r04y1j22	683	6	certain	certain	JJ
cord-023439-r04y1j22	683	7	field	field	NN
cord-023439-r04y1j22	683	8	is	be	VBZ
cord-023439-r04y1j22	683	9	reserved	reserve	VBN
cord-023439-r04y1j22	683	10	to	to	TO
cord-023439-r04y1j22	683	11	specify	specify	VB
cord-023439-r04y1j22	683	12	the	the	DT
cord-023439-r04y1j22	683	13	relation	relation	NN
cord-023439-r04y1j22	683	14	of	of	IN
cord-023439-r04y1j22	683	15	the	the	DT
cord-023439-r04y1j22	683	16	record	record	NN
cord-023439-r04y1j22	683	17	to	to	IN
cord-023439-r04y1j22	683	18	a	a	DT
cord-023439-r04y1j22	683	19	record	record	NN
cord-023439-r04y1j22	683	20	in	in	IN
cord-023439-r04y1j22	683	21	another	another	DT
cord-023439-r04y1j22	683	22	database	database	NN
cord-023439-r04y1j22	683	23	at	at	IN
cord-023439-r04y1j22	683	24	a	a	DT
cord-023439-r04y1j22	683	25	higher	high	JJR
cord-023439-r04y1j22	683	26	level	level	NN
cord-023439-r04y1j22	683	27	.	.	.
cord-023439-r04y1j22	684	1	Thus	thus	RB
cord-023439-r04y1j22	684	2	,	,	,
cord-023439-r04y1j22	684	3	the	the	DT
cord-023439-r04y1j22	684	4	database	database	NN
cord-023439-r04y1j22	684	5	is	be	VBZ
cord-023439-r04y1j22	684	6	essentially	essentially	RB
cord-023439-r04y1j22	684	7	five	five	CD
cord-023439-r04y1j22	684	8	databases	database	NNS
cord-023439-r04y1j22	684	9	linked	link	VBN
cord-023439-r04y1j22	684	10	by	by	IN
cord-023439-r04y1j22	684	11	a	a	DT
cord-023439-r04y1j22	684	12	hierarchy	hierarchy	NN
cord-023439-r04y1j22	684	13	of	of	IN
cord-023439-r04y1j22	684	14	one	one	CD
cord-023439-r04y1j22	684	15	-	-	HYPH
cord-023439-r04y1j22	684	16	to	to	IN
cord-023439-r04y1j22	684	17	-	-	HYPH
cord-023439-r04y1j22	684	18	many	many	JJ
cord-023439-r04y1j22	684	19	relations	relation	NNS
cord-023439-r04y1j22	684	20	,	,	,
cord-023439-r04y1j22	684	21	organizing	organize	VBG
cord-023439-r04y1j22	684	22	information	information	NN
cord-023439-r04y1j22	684	23	in	in	IN
cord-023439-r04y1j22	684	24	a	a	DT
cord-023439-r04y1j22	684	25	folder	folder	NN
cord-023439-r04y1j22	684	26	-	-	HYPH
cord-023439-r04y1j22	684	27	like	like	JJ
cord-023439-r04y1j22	684	28	structure	structure	NN
cord-023439-r04y1j22	684	29	.	.	.
cord-023439-r04y1j22	685	1	Importantly	importantly	RB
cord-023439-r04y1j22	685	2	,	,	,
cord-023439-r04y1j22	685	3	the	the	DT
cord-023439-r04y1j22	685	4	database	database	NN
cord-023439-r04y1j22	685	5	system	system	NN
cord-023439-r04y1j22	685	6	allows	allow	VBZ
cord-023439-r04y1j22	685	7	multiple	multiple	JJ
cord-023439-r04y1j22	685	8	users	user	NNS
cord-023439-r04y1j22	685	9	to	to	TO
cord-023439-r04y1j22	685	10	access	access	VB
cord-023439-r04y1j22	685	11	and	and	CC
cord-023439-r04y1j22	685	12	edit	edit	VB
cord-023439-r04y1j22	685	13	records	record	NNS
cord-023439-r04y1j22	685	14	simultaneously	simultaneously	RB
cord-023439-r04y1j22	685	15	,	,	,
cord-023439-r04y1j22	685	16	and	and	CC
cord-023439-r04y1j22	685	17	the	the	DT
cord-023439-r04y1j22	685	18	data	datum	NNS
cord-023439-r04y1j22	685	19	entered	enter	VBD
cord-023439-r04y1j22	685	20	in	in	IN
cord-023439-r04y1j22	685	21	one	one	CD
cord-023439-r04y1j22	685	22	database	database	NN
cord-023439-r04y1j22	685	23	immediately	immediately	RB
cord-023439-r04y1j22	685	24	becomes	become	VBZ
cord-023439-r04y1j22	685	25	accessible	accessible	JJ
cord-023439-r04y1j22	685	26	through	through	IN
cord-023439-r04y1j22	685	27	the	the	DT
cord-023439-r04y1j22	685	28	other	other	JJ
cord-023439-r04y1j22	685	29	databases	database	NNS
cord-023439-r04y1j22	685	30	.	.	.
cord-023439-r04y1j22	686	1	The	the	DT
cord-023439-r04y1j22	686	2	limitations	limitation	NNS
cord-023439-r04y1j22	686	3	of	of	IN
cord-023439-r04y1j22	686	4	laboratory	laboratory	NN
cord-023439-r04y1j22	686	5	notebooks	notebook	NNS
cord-023439-r04y1j22	686	6	are	be	VBP
cord-023439-r04y1j22	686	7	apparent	apparent	JJ
cord-023439-r04y1j22	686	8	when	when	WRB
cord-023439-r04y1j22	686	9	looking	look	VBG
cord-023439-r04y1j22	686	10	for	for	IN
cord-023439-r04y1j22	686	11	information	information	NN
cord-023439-r04y1j22	686	12	,	,	,
cord-023439-r04y1j22	686	13	which	which	WDT
cord-023439-r04y1j22	686	14	is	be	VBZ
cord-023439-r04y1j22	686	15	dispersed	disperse	VBN
cord-023439-r04y1j22	686	16	throughout	throughout	IN
cord-023439-r04y1j22	686	17	one	one	CD
cord-023439-r04y1j22	686	18	or	or	CC
cord-023439-r04y1j22	686	19	more	more	JJR
cord-023439-r04y1j22	686	20	notebooks	notebook	NNS
cord-023439-r04y1j22	686	21	,	,	,
cord-023439-r04y1j22	686	22	or	or	CC
cord-023439-r04y1j22	686	23	possibly	possibly	RB
cord-023439-r04y1j22	686	24	on	on	IN
cord-023439-r04y1j22	686	25	loose	loose	JJ
cord-023439-r04y1j22	686	26	sheets	sheet	NNS
cord-023439-r04y1j22	686	27	of	of	IN
cord-023439-r04y1j22	686	28	paper	paper	NN
cord-023439-r04y1j22	686	29	or	or	CC
cord-023439-r04y1j22	686	30	printouts	printout	NNS
cord-023439-r04y1j22	686	31	'	'	POS
cord-023439-r04y1j22	686	32	somewhere	somewhere	RB
cord-023439-r04y1j22	686	33	'	'	''
cord-023439-r04y1j22	686	34	.	.	.
cord-023439-r04y1j22	687	1	The	the	DT
cord-023439-r04y1j22	687	2	often	often	RB
cord-023439-r04y1j22	687	3	complicated	complicated	JJ
cord-023439-r04y1j22	687	4	process	process	NN
cord-023439-r04y1j22	687	5	of	of	IN
cord-023439-r04y1j22	687	6	gathering	gather	VBG
cord-023439-r04y1j22	687	7	laboratory	laboratory	NN
cord-023439-r04y1j22	687	8	data	datum	NNS
cord-023439-r04y1j22	687	9	or	or	CC
cord-023439-r04y1j22	687	10	results	result	NNS
cord-023439-r04y1j22	687	11	when	when	WRB
cord-023439-r04y1j22	687	12	writing	write	VBG
cord-023439-r04y1j22	687	13	grant	grant	NN
cord-023439-r04y1j22	687	14	applications	application	NNS
cord-023439-r04y1j22	687	15	or	or	CC
cord-023439-r04y1j22	687	16	research	research	NN
cord-023439-r04y1j22	687	17	papers	paper	NNS
cord-023439-r04y1j22	687	18	is	be	VBZ
cord-023439-r04y1j22	687	19	made	make	VBN
cord-023439-r04y1j22	687	20	considerably	considerably	RB
cord-023439-r04y1j22	687	21	easier	easy	JJR
cord-023439-r04y1j22	687	22	with	with	IN
cord-023439-r04y1j22	687	23	the	the	DT
cord-023439-r04y1j22	687	24	database	database	NN
cord-023439-r04y1j22	687	25	system	system	NN
cord-023439-r04y1j22	687	26	.	.	.
cord-023439-r04y1j22	688	1	Thus	thus	RB
cord-023439-r04y1j22	688	2	,	,	,
cord-023439-r04y1j22	688	3	the	the	DT
cord-023439-r04y1j22	688	4	database	database	NN
cord-023439-r04y1j22	688	5	solution	solution	NN
cord-023439-r04y1j22	688	6	presented	present	VBN
cord-023439-r04y1j22	688	7	should	should	MD
cord-023439-r04y1j22	688	8	be	be	VB
cord-023439-r04y1j22	688	9	broadly	broadly	RB
cord-023439-r04y1j22	688	10	attractive	attractive	JJ
cord-023439-r04y1j22	688	11	to	to	IN
cord-023439-r04y1j22	688	12	researchers	researcher	NNS
cord-023439-r04y1j22	688	13	,	,	,
cord-023439-r04y1j22	688	14	irrespective	irrespective	RB
cord-023439-r04y1j22	688	15	of	of	IN
cord-023439-r04y1j22	688	16	their	-PRON-	PRP$
cord-023439-r04y1j22	688	17	scientific	scientific	JJ
cord-023439-r04y1j22	688	18	discipline	discipline	NN
cord-023439-r04y1j22	688	19	.	.	.
cord-023439-r04y1j22	689	1	An	an	DT
cord-023439-r04y1j22	689	2	effective	effective	JJ
cord-023439-r04y1j22	689	3	SARS	SARS	NNP
cord-023439-r04y1j22	689	4	vaccine	vaccine	NN
cord-023439-r04y1j22	689	5	is	be	VBZ
cord-023439-r04y1j22	689	6	likely	likely	JJ
cord-023439-r04y1j22	689	7	to	to	TO
cord-023439-r04y1j22	689	8	include	include	VB
cord-023439-r04y1j22	689	9	components	component	NNS
cord-023439-r04y1j22	689	10	that	that	WDT
cord-023439-r04y1j22	689	11	can	can	MD
cord-023439-r04y1j22	689	12	induce	induce	VB
cord-023439-r04y1j22	689	13	specific	specific	JJ
cord-023439-r04y1j22	689	14	cytotoxic	cytotoxic	JJ
cord-023439-r04y1j22	689	15	T	t	NN
cord-023439-r04y1j22	689	16	-	-	HYPH
cord-023439-r04y1j22	689	17	cell	cell	NN
cord-023439-r04y1j22	689	18	(	(	-LRB-
cord-023439-r04y1j22	689	19	CTL	CTL	NNP
cord-023439-r04y1j22	689	20	)	)	-RRB-
cord-023439-r04y1j22	689	21	responses	response	NNS
cord-023439-r04y1j22	689	22	.	.	.
cord-023439-r04y1j22	690	1	The	the	DT
cord-023439-r04y1j22	690	2	specificities	specificity	NNS
cord-023439-r04y1j22	690	3	of	of	IN
cord-023439-r04y1j22	690	4	such	such	JJ
cord-023439-r04y1j22	690	5	responses	response	NNS
cord-023439-r04y1j22	690	6	are	be	VBP
cord-023439-r04y1j22	690	7	governed	govern	VBN
cord-023439-r04y1j22	690	8	by	by	IN
cord-023439-r04y1j22	690	9	HLArestricted	hlarestricted	JJ
cord-023439-r04y1j22	690	10	presentation	presentation	NN
cord-023439-r04y1j22	690	11	of	of	IN
cord-023439-r04y1j22	690	12	SARS	SARS	NNP
cord-023439-r04y1j22	690	13	-	-	HYPH
cord-023439-r04y1j22	690	14	derived	derive	VBN
cord-023439-r04y1j22	690	15	peptide	peptide	NN
cord-023439-r04y1j22	690	16	epitopes	epitope	NNS
cord-023439-r04y1j22	690	17	.	.	.
cord-023439-r04y1j22	691	1	Exact	exact	JJ
cord-023439-r04y1j22	691	2	knowledge	knowledge	NN
cord-023439-r04y1j22	691	3	of	of	IN
cord-023439-r04y1j22	691	4	how	how	WRB
cord-023439-r04y1j22	691	5	the	the	DT
cord-023439-r04y1j22	691	6	immune	immune	JJ
cord-023439-r04y1j22	691	7	system	system	NN
cord-023439-r04y1j22	691	8	handles	handle	VBZ
cord-023439-r04y1j22	691	9	protein	protein	NN
cord-023439-r04y1j22	691	10	antigens	antigen	NNS
cord-023439-r04y1j22	691	11	would	would	MD
cord-023439-r04y1j22	691	12	allow	allow	VB
cord-023439-r04y1j22	691	13	for	for	IN
cord-023439-r04y1j22	691	14	the	the	DT
cord-023439-r04y1j22	691	15	identification	identification	NN
cord-023439-r04y1j22	691	16	of	of	IN
cord-023439-r04y1j22	691	17	such	such	JJ
cord-023439-r04y1j22	691	18	linear	linear	JJ
cord-023439-r04y1j22	691	19	sequences	sequence	NNS
cord-023439-r04y1j22	691	20	directly	directly	RB
cord-023439-r04y1j22	691	21	from	from	IN
cord-023439-r04y1j22	691	22	genomic	genomic	JJ
cord-023439-r04y1j22	691	23	/	/	SYM
cord-023439-r04y1j22	691	24	proteomic	proteomic	JJ
cord-023439-r04y1j22	691	25	sequence	sequence	NN
cord-023439-r04y1j22	691	26	information	information	NN
cord-023439-r04y1j22	691	27	.	.	.
cord-023439-r04y1j22	692	1	The	the	DT
cord-023439-r04y1j22	692	2	latter	latter	JJ
cord-023439-r04y1j22	692	3	was	be	VBD
cord-023439-r04y1j22	692	4	recently	recently	RB
cord-023439-r04y1j22	692	5	established	establish	VBN
cord-023439-r04y1j22	692	6	when	when	WRB
cord-023439-r04y1j22	692	7	a	a	DT
cord-023439-r04y1j22	692	8	causative	causative	JJ
cord-023439-r04y1j22	692	9	coronavirus	coronavirus	NN
cord-023439-r04y1j22	692	10	(	(	-LRB-
cord-023439-r04y1j22	692	11	SARS	SARS	NNP
cord-023439-r04y1j22	692	12	CoV	CoV	NNP
cord-023439-r04y1j22	692	13	)	)	-RRB-
cord-023439-r04y1j22	692	14	was	be	VBD
cord-023439-r04y1j22	692	15	isolated	isolate	VBN
cord-023439-r04y1j22	692	16	and	and	CC
cord-023439-r04y1j22	692	17	full	full	JJ
cord-023439-r04y1j22	692	18	-	-	HYPH
cord-023439-r04y1j22	692	19	length	length	NN
cord-023439-r04y1j22	692	20	sequenced	sequence	VBN
cord-023439-r04y1j22	692	21	.	.	.
cord-023439-r04y1j22	693	1	Here	here	RB
cord-023439-r04y1j22	693	2	,	,	,
cord-023439-r04y1j22	693	3	we	-PRON-	PRP
cord-023439-r04y1j22	693	4	have	have	VBP
cord-023439-r04y1j22	693	5	combined	combine	VBN
cord-023439-r04y1j22	693	6	advanced	advanced	JJ
cord-023439-r04y1j22	693	7	bioinformatics	bioinformatic	NNS
cord-023439-r04y1j22	693	8	and	and	CC
cord-023439-r04y1j22	693	9	high	high	JJ
cord-023439-r04y1j22	693	10	-	-	HYPH
cord-023439-r04y1j22	693	11	throughput	throughput	NN
cord-023439-r04y1j22	693	12	immunology	immunology	NN
cord-023439-r04y1j22	693	13	to	to	TO
cord-023439-r04y1j22	693	14	perform	perform	VB
cord-023439-r04y1j22	693	15	an	an	DT
cord-023439-r04y1j22	693	16	HLA	HLA	NNP
cord-023439-r04y1j22	693	17	supertype	supertype	NN
cord-023439-r04y1j22	693	18	,	,	,
cord-023439-r04y1j22	693	19	genome	genome	NN
cord-023439-r04y1j22	693	20	-	-	HYPH
cord-023439-r04y1j22	693	21	wide	wide	JJ
cord-023439-r04y1j22	693	22	scan	scan	NN
cord-023439-r04y1j22	693	23	for	for	IN
cord-023439-r04y1j22	693	24	SARS	SARS	NNP
cord-023439-r04y1j22	693	25	-	-	HYPH
cord-023439-r04y1j22	693	26	specific	specific	JJ
cord-023439-r04y1j22	693	27	cytotoxic	cytotoxic	JJ
cord-023439-r04y1j22	693	28	T	t	NN
cord-023439-r04y1j22	693	29	cell	cell	NN
cord-023439-r04y1j22	693	30	epitopes	epitope	NNS
cord-023439-r04y1j22	693	31	.	.	.
cord-023439-r04y1j22	694	1	The	the	DT
cord-023439-r04y1j22	694	2	scan	scan	NN
cord-023439-r04y1j22	694	3	includes	include	VBZ
cord-023439-r04y1j22	694	4	all	all	DT
cord-023439-r04y1j22	694	5	nine	nine	CD
cord-023439-r04y1j22	694	6	human	human	JJ
cord-023439-r04y1j22	694	7	HLA	HLA	NNP
cord-023439-r04y1j22	694	8	supertypes	supertype	NNS
cord-023439-r04y1j22	694	9	in	in	IN
cord-023439-r04y1j22	694	10	total	total	JJ
cord-023439-r04y1j22	694	11	covering	covering	NN
cord-023439-r04y1j22	694	12	>	>	SYM
cord-023439-r04y1j22	694	13	99	99	CD
cord-023439-r04y1j22	694	14	%	%	NN
cord-023439-r04y1j22	694	15	of	of	IN
cord-023439-r04y1j22	694	16	all	all	DT
cord-023439-r04y1j22	694	17	major	major	JJ
cord-023439-r04y1j22	694	18	human	human	JJ
cord-023439-r04y1j22	694	19	populations	population	NNS
cord-023439-r04y1j22	694	20	.	.	.
cord-023439-r04y1j22	695	1	For	for	IN
cord-023439-r04y1j22	695	2	each	each	DT
cord-023439-r04y1j22	695	3	HLA	HLA	NNP
cord-023439-r04y1j22	695	4	supertype	supertype	NN
cord-023439-r04y1j22	695	5	,	,	,
cord-023439-r04y1j22	695	6	we	-PRON-	PRP
cord-023439-r04y1j22	695	7	have	have	VBP
cord-023439-r04y1j22	695	8	selected	select	VBN
cord-023439-r04y1j22	695	9	the	the	DT
cord-023439-r04y1j22	695	10	15	15	CD
cord-023439-r04y1j22	695	11	top	top	JJ
cord-023439-r04y1j22	695	12	candidates	candidate	NNS
cord-023439-r04y1j22	695	13	for	for	IN
cord-023439-r04y1j22	695	14	test	test	NN
cord-023439-r04y1j22	695	15	in	in	IN
cord-023439-r04y1j22	695	16	biochemical	biochemical	JJ
cord-023439-r04y1j22	695	17	-	-	HYPH
cord-023439-r04y1j22	695	18	binding	bind	VBG
cord-023439-r04y1j22	695	19	assays	assay	NNS
cord-023439-r04y1j22	695	20	.	.	.
cord-023439-r04y1j22	696	1	At	at	IN
cord-023439-r04y1j22	696	2	this	this	DT
cord-023439-r04y1j22	696	3	time	time	NN
cord-023439-r04y1j22	696	4	(	(	-LRB-
cord-023439-r04y1j22	696	5	approximately	approximately	RB
cord-023439-r04y1j22	696	6	6	6	CD
cord-023439-r04y1j22	696	7	months	month	NNS
cord-023439-r04y1j22	696	8	after	after	IN
cord-023439-r04y1j22	696	9	the	the	DT
cord-023439-r04y1j22	696	10	genome	genome	NN
cord-023439-r04y1j22	696	11	was	be	VBD
cord-023439-r04y1j22	696	12	established	establish	VBN
cord-023439-r04y1j22	696	13	)	)	-RRB-
cord-023439-r04y1j22	696	14	,	,	,
cord-023439-r04y1j22	696	15	we	-PRON-	PRP
cord-023439-r04y1j22	696	16	have	have	VBP
cord-023439-r04y1j22	696	17	tested	test	VBN
cord-023439-r04y1j22	696	18	the	the	DT
cord-023439-r04y1j22	696	19	majority	majority	NN
cord-023439-r04y1j22	696	20	of	of	IN
cord-023439-r04y1j22	696	21	the	the	DT
cord-023439-r04y1j22	696	22	HLA	HLA	NNP
cord-023439-r04y1j22	696	23	supertypes	supertype	NNS
cord-023439-r04y1j22	696	24	and	and	CC
cord-023439-r04y1j22	696	25	identified	identify	VBD
cord-023439-r04y1j22	696	26	almost	almost	RB
cord-023439-r04y1j22	696	27	100	100	CD
cord-023439-r04y1j22	696	28	potential	potential	JJ
cord-023439-r04y1j22	696	29	vaccine	vaccine	NN
cord-023439-r04y1j22	696	30	candidates	candidate	NNS
cord-023439-r04y1j22	696	31	.	.	.
cord-023439-r04y1j22	697	1	These	these	DT
cord-023439-r04y1j22	697	2	should	should	MD
cord-023439-r04y1j22	697	3	be	be	VB
cord-023439-r04y1j22	697	4	further	further	RB
cord-023439-r04y1j22	697	5	validated	validate	VBN
cord-023439-r04y1j22	697	6	in	in	IN
cord-023439-r04y1j22	697	7	SARS	SARS	NNP
cord-023439-r04y1j22	697	8	survivors	survivor	NNS
cord-023439-r04y1j22	697	9	and	and	CC
cord-023439-r04y1j22	697	10	used	use	VBD
cord-023439-r04y1j22	697	11	for	for	IN
cord-023439-r04y1j22	697	12	vaccine	vaccine	NN
cord-023439-r04y1j22	697	13	formulation	formulation	NN
cord-023439-r04y1j22	697	14	.	.	.
cord-023439-r04y1j22	698	1	We	-PRON-	PRP
cord-023439-r04y1j22	698	2	suggest	suggest	VBP
cord-023439-r04y1j22	698	3	that	that	IN
cord-023439-r04y1j22	698	4	immunobioinformatics	immunobioinformatic	NNS
cord-023439-r04y1j22	698	5	may	may	MD
cord-023439-r04y1j22	698	6	become	become	VB
cord-023439-r04y1j22	698	7	a	a	DT
cord-023439-r04y1j22	698	8	fast	fast	JJ
cord-023439-r04y1j22	698	9	and	and	CC
cord-023439-r04y1j22	698	10	valuable	valuable	JJ
cord-023439-r04y1j22	698	11	tool	tool	NN
cord-023439-r04y1j22	698	12	in	in	IN
cord-023439-r04y1j22	698	13	rational	rational	JJ
cord-023439-r04y1j22	698	14	vaccine	vaccine	NN
cord-023439-r04y1j22	698	15	design	design	NN
cord-023439-r04y1j22	698	16	.	.	.
cord-023439-r04y1j22	699	1	Rationale	rationale	NN
cord-023439-r04y1j22	699	2	:	:	:
cord-023439-r04y1j22	700	1	Major	major	JJ
cord-023439-r04y1j22	700	2	histocompatibility	histocompatibility	NN
cord-023439-r04y1j22	700	3	complex	complex	NN
cord-023439-r04y1j22	700	4	class	class	NN
cord-023439-r04y1j22	701	1	I	-PRON-	PRP
cord-023439-r04y1j22	701	2	(	(	-LRB-
cord-023439-r04y1j22	701	3	MHC	MHC	NNP
cord-023439-r04y1j22	701	4	I	I	NNP
cord-023439-r04y1j22	701	5	)	)	-RRB-
cord-023439-r04y1j22	701	6	molecules	molecule	NNS
cord-023439-r04y1j22	701	7	monitor	monitor	VBP
cord-023439-r04y1j22	701	8	the	the	DT
cord-023439-r04y1j22	701	9	protein	protein	NN
cord-023439-r04y1j22	701	10	content	content	NN
cord-023439-r04y1j22	701	11	of	of	IN
cord-023439-r04y1j22	701	12	the	the	DT
cord-023439-r04y1j22	701	13	cell	cell	NN
cord-023439-r04y1j22	701	14	by	by	IN
cord-023439-r04y1j22	701	15	binding	bind	VBG
cord-023439-r04y1j22	701	16	small	small	JJ
cord-023439-r04y1j22	701	17	derived	derive	VBN
cord-023439-r04y1j22	701	18	peptides	peptide	NNS
cord-023439-r04y1j22	701	19	and	and	CC
cord-023439-r04y1j22	701	20	presenting	present	VBG
cord-023439-r04y1j22	701	21	them	-PRON-	PRP
cord-023439-r04y1j22	701	22	to	to	IN
cord-023439-r04y1j22	701	23	cytotoxic	cytotoxic	JJ
cord-023439-r04y1j22	701	24	CD8	CD8	NNP
cord-023439-r04y1j22	701	25	þ	þ	NNP
cord-023439-r04y1j22	701	26	T	T	NNP
cord-023439-r04y1j22	701	27	cells	cell	NNS
cord-023439-r04y1j22	701	28	.	.	.
cord-023439-r04y1j22	702	1	The	the	DT
cord-023439-r04y1j22	702	2	goal	goal	NN
cord-023439-r04y1j22	702	3	of	of	IN
cord-023439-r04y1j22	702	4	the	the	DT
cord-023439-r04y1j22	702	5	human	human	JJ
cord-023439-r04y1j22	702	6	MHC	MHC	NNP
cord-023439-r04y1j22	702	7	project	project	NN
cord-023439-r04y1j22	702	8	is	be	VBZ
cord-023439-r04y1j22	702	9	to	to	TO
cord-023439-r04y1j22	702	10	predict	predict	VB
cord-023439-r04y1j22	702	11	the	the	DT
cord-023439-r04y1j22	702	12	binding	binding	NN
cord-023439-r04y1j22	702	13	strength	strength	NN
cord-023439-r04y1j22	702	14	of	of	IN
cord-023439-r04y1j22	702	15	any	any	DT
cord-023439-r04y1j22	702	16	given	give	VBN
cord-023439-r04y1j22	702	17	peptide	peptide	NN
cord-023439-r04y1j22	702	18	/	/	SYM
cord-023439-r04y1j22	702	19	MHC	MHC	NNP
cord-023439-r04y1j22	702	20	complex	complex	NN
cord-023439-r04y1j22	702	21	.	.	.
cord-023439-r04y1j22	703	1	This	this	DT
cord-023439-r04y1j22	703	2	prediction	prediction	NN
cord-023439-r04y1j22	703	3	allows	allow	VBZ
cord-023439-r04y1j22	703	4	the	the	DT
cord-023439-r04y1j22	703	5	design	design	NN
cord-023439-r04y1j22	703	6	of	of	IN
cord-023439-r04y1j22	703	7	peptide	peptide	NN
cord-023439-r04y1j22	703	8	-	-	HYPH
cord-023439-r04y1j22	703	9	based	base	VBN
cord-023439-r04y1j22	703	10	vaccines	vaccine	NNS
cord-023439-r04y1j22	703	11	.	.	.
cord-023439-r04y1j22	704	1	The	the	DT
cord-023439-r04y1j22	704	2	prediction	prediction	NN
cord-023439-r04y1j22	704	3	requires	require	VBZ
cord-023439-r04y1j22	704	4	representative	representative	JJ
cord-023439-r04y1j22	704	5	binding	bind	VBG
cord-023439-r04y1j22	704	6	data	datum	NNS
cord-023439-r04y1j22	704	7	from	from	IN
cord-023439-r04y1j22	704	8	MHC	MHC	NNP
cord-023439-r04y1j22	704	9	alleles	allele	NNS
cord-023439-r04y1j22	704	10	from	from	IN
cord-023439-r04y1j22	704	11	all	all	PDT
cord-023439-r04y1j22	704	12	the	the	DT
cord-023439-r04y1j22	704	13	nine	nine	CD
cord-023439-r04y1j22	704	14	HLA	HLA	NNP
cord-023439-r04y1j22	704	15	supertypes	supertype	NNS
cord-023439-r04y1j22	704	16	.	.	.
cord-023439-r04y1j22	705	1	Here	here	RB
cord-023439-r04y1j22	705	2	,	,	,
cord-023439-r04y1j22	705	3	we	-PRON-	PRP
cord-023439-r04y1j22	705	4	describe	describe	VBP
cord-023439-r04y1j22	705	5	the	the	DT
cord-023439-r04y1j22	705	6	genetic	genetic	JJ
cord-023439-r04y1j22	705	7	construction	construction	NN
cord-023439-r04y1j22	705	8	,	,	,
cord-023439-r04y1j22	705	9	protein	protein	NN
cord-023439-r04y1j22	705	10	production	production	NN
cord-023439-r04y1j22	705	11	and	and	CC
cord-023439-r04y1j22	705	12	purification	purification	NN
cord-023439-r04y1j22	705	13	as	as	RB
cord-023439-r04y1j22	705	14	well	well	RB
cord-023439-r04y1j22	705	15	as	as	IN
cord-023439-r04y1j22	705	16	the	the	DT
cord-023439-r04y1j22	705	17	establishment	establishment	NN
cord-023439-r04y1j22	705	18	-	-	HYPH
cord-023439-r04y1j22	705	19	binding	bind	VBG
cord-023439-r04y1j22	705	20	assays	assay	NNS
cord-023439-r04y1j22	705	21	for	for	IN
cord-023439-r04y1j22	705	22	two	two	CD
cord-023439-r04y1j22	705	23	recombinant	recombinant	JJ
cord-023439-r04y1j22	705	24	MHC	MHC	NNP
cord-023439-r04y1j22	705	25	supertype	supertype	NN
cord-023439-r04y1j22	705	26	alleles	allele	NNS
cord-023439-r04y1j22	705	27	,	,	,
cord-023439-r04y1j22	705	28	HLA	HLA	NNP
cord-023439-r04y1j22	705	29	-	-	HYPH
cord-023439-r04y1j22	705	30	B*1501	B*1501	NNP
cord-023439-r04y1j22	705	31	and	and	CC
cord-023439-r04y1j22	705	32	HLA	HLA	NNP
cord-023439-r04y1j22	705	33	-	-	HYPH
cord-023439-r04y1j22	705	34	B*5801	B*5801	NNP
cord-023439-r04y1j22	705	35	.	.	.
cord-023439-r04y1j22	706	1	Methods	method	NNS
cord-023439-r04y1j22	706	2	:	:	:
cord-023439-r04y1j22	706	3	Using	use	VBG
cord-023439-r04y1j22	706	4	the	the	DT
cord-023439-r04y1j22	706	5	Quikchange	Quikchange	NNP
cord-023439-r04y1j22	706	6	Multisite	Multisite	NNP
cord-023439-r04y1j22	706	7	Directed	Directed	NNP
cord-023439-r04y1j22	706	8	Mutagenesis	Mutagenesis	NNP
cord-023439-r04y1j22	706	9	Kit	kit	NN
cord-023439-r04y1j22	706	10	(	(	-LRB-
cord-023439-r04y1j22	706	11	Stratagene	Stratagene	NNP
cord-023439-r04y1j22	706	12	)	)	-RRB-
cord-023439-r04y1j22	706	13	,	,	,
cord-023439-r04y1j22	706	14	codon	codon	NN
cord-023439-r04y1j22	706	15	-	-	HYPH
cord-023439-r04y1j22	706	16	optimized	optimize	VBN
cord-023439-r04y1j22	706	17	genes	gene	NNS
cord-023439-r04y1j22	706	18	encoding	encode	VBG
cord-023439-r04y1j22	706	19	HLA	HLA	NNP
cord-023439-r04y1j22	706	20	-	-	HYPH
cord-023439-r04y1j22	706	21	B*1501	B*1501	NNP
cord-023439-r04y1j22	706	22	and	and	CC
cord-023439-r04y1j22	706	23	HLA	HLA	NNP
cord-023439-r04y1j22	706	24	-	-	HYPH
cord-023439-r04y1j22	706	25	B*5801	B*5801	NNP
cord-023439-r04y1j22	706	26	are	be	VBP
cord-023439-r04y1j22	706	27	created	create	VBN
cord-023439-r04y1j22	706	28	.	.	.
cord-023439-r04y1j22	707	1	The	the	DT
cord-023439-r04y1j22	707	2	two	two	CD
cord-023439-r04y1j22	707	3	MHC	MHC	NNP
cord-023439-r04y1j22	707	4	I	-PRON-	PRP
cord-023439-r04y1j22	707	5	molecules	molecule	NNS
cord-023439-r04y1j22	707	6	are	be	VBP
cord-023439-r04y1j22	707	7	fermented	ferment	VBN
cord-023439-r04y1j22	707	8	and	and	CC
cord-023439-r04y1j22	707	9	purified	purify	VBN
cord-023439-r04y1j22	707	10	by	by	IN
cord-023439-r04y1j22	707	11	ion	ion	NN
cord-023439-r04y1j22	707	12	exchange	exchange	NN
cord-023439-r04y1j22	707	13	chromatography	chromatography	NN
cord-023439-r04y1j22	707	14	,	,	,
cord-023439-r04y1j22	707	15	hydrophobic	hydrophobic	JJ
cord-023439-r04y1j22	707	16	interaction	interaction	NN
cord-023439-r04y1j22	707	17	chromatography	chromatography	NN
cord-023439-r04y1j22	707	18	and	and	CC
cord-023439-r04y1j22	707	19	size	size	NN
cord-023439-r04y1j22	707	20	exclusion	exclusion	NN
cord-023439-r04y1j22	707	21	chromatography	chromatography	NN
cord-023439-r04y1j22	707	22	.	.	.
cord-023439-r04y1j22	708	1	The	the	DT
cord-023439-r04y1j22	708	2	binding	binding	NN
cord-023439-r04y1j22	708	3	(	(	-LRB-
cord-023439-r04y1j22	708	4	KD	KD	NNP
cord-023439-r04y1j22	708	5	)	)	-RRB-
cord-023439-r04y1j22	708	6	of	of	IN
cord-023439-r04y1j22	708	7	natural	natural	JJ
cord-023439-r04y1j22	708	8	T	T	NNP
cord-023439-r04y1j22	708	9	-	-	HYPH
cord-023439-r04y1j22	708	10	cell	cell	NN
cord-023439-r04y1j22	708	11	epitopes	epitope	NNS
cord-023439-r04y1j22	708	12	,	,	,
cord-023439-r04y1j22	708	13	as	as	RB
cord-023439-r04y1j22	708	14	well	well	RB
cord-023439-r04y1j22	708	15	as	as	IN
cord-023439-r04y1j22	708	16	predicted	predict	VBN
cord-023439-r04y1j22	708	17	peptide	peptide	NN
cord-023439-r04y1j22	708	18	ligands	ligand	NNS
cord-023439-r04y1j22	708	19	,	,	,
cord-023439-r04y1j22	708	20	is	be	VBZ
cord-023439-r04y1j22	708	21	described	describe	VBN
cord-023439-r04y1j22	708	22	by	by	IN
cord-023439-r04y1j22	708	23	radioactive	radioactive	JJ
cord-023439-r04y1j22	708	24	immunoassays	immunoassay	NNS
cord-023439-r04y1j22	708	25	(	(	-LRB-
cord-023439-r04y1j22	708	26	RIAs	RIAs	NNP
cord-023439-r04y1j22	708	27	)	)	-RRB-
cord-023439-r04y1j22	708	28	and	and	CC
cord-023439-r04y1j22	708	29	enzyme	enzyme	NN
cord-023439-r04y1j22	708	30	-	-	HYPH
cord-023439-r04y1j22	708	31	linked	link	VBN
cord-023439-r04y1j22	708	32	immunosorbent	immunosorbent	JJ
cord-023439-r04y1j22	708	33	assays	assay	NNS
cord-023439-r04y1j22	708	34	(	(	-LRB-
cord-023439-r04y1j22	708	35	ELISAs	elisa	NNS
cord-023439-r04y1j22	708	36	)	)	-RRB-
cord-023439-r04y1j22	708	37	.	.	.
cord-023439-r04y1j22	709	1	The	the	DT
cord-023439-r04y1j22	709	2	MHC	MHC	NNP
cord-023439-r04y1j22	709	3	molecules	molecule	NNS
cord-023439-r04y1j22	709	4	are	be	VBP
cord-023439-r04y1j22	709	5	biotinylated	biotinylate	VBN
cord-023439-r04y1j22	709	6	during	during	IN
cord-023439-r04y1j22	709	7	expression	expression	NN
cord-023439-r04y1j22	709	8	.	.	.
cord-023439-r04y1j22	710	1	Results	result	NNS
cord-023439-r04y1j22	710	2	:	:	:
cord-023439-r04y1j22	711	1	The	the	DT
cord-023439-r04y1j22	711	2	expression	expression	NN
cord-023439-r04y1j22	711	3	of	of	IN
cord-023439-r04y1j22	711	4	MHC	MHC	NNP
cord-023439-r04y1j22	711	5	I	-PRON-	PRP
cord-023439-r04y1j22	711	6	resulted	result	VBD
cord-023439-r04y1j22	711	7	in	in	IN
cord-023439-r04y1j22	711	8	multiple	multiple	JJ
cord-023439-r04y1j22	711	9	disulfide	disulfide	JJ
cord-023439-r04y1j22	711	10	bond	bond	NN
cord-023439-r04y1j22	711	11	isomers	isomer	NNS
cord-023439-r04y1j22	711	12	,	,	,
cord-023439-r04y1j22	711	13	which	which	WDT
cord-023439-r04y1j22	711	14	are	be	VBP
cord-023439-r04y1j22	711	15	separated	separate	VBN
cord-023439-r04y1j22	711	16	by	by	IN
cord-023439-r04y1j22	711	17	hydrophobic	hydrophobic	JJ
cord-023439-r04y1j22	711	18	interaction	interaction	NN
cord-023439-r04y1j22	711	19	chromatography	chromatography	NN
cord-023439-r04y1j22	711	20	and	and	CC
cord-023439-r04y1j22	711	21	used	use	VBN
cord-023439-r04y1j22	711	22	in	in	IN
cord-023439-r04y1j22	711	23	subsequent	subsequent	JJ
cord-023439-r04y1j22	711	24	binding	binding	NN
cord-023439-r04y1j22	711	25	studies	study	NNS
cord-023439-r04y1j22	711	26	resulting	result	VBG
cord-023439-r04y1j22	711	27	in	in	IN
cord-023439-r04y1j22	711	28	the	the	DT
cord-023439-r04y1j22	711	29	determination	determination	NN
cord-023439-r04y1j22	711	30	of	of	IN
cord-023439-r04y1j22	711	31	KD	KD	NNP
cord-023439-r04y1j22	711	32	for	for	IN
cord-023439-r04y1j22	711	33	various	various	JJ
cord-023439-r04y1j22	711	34	peptide	peptide	NN
cord-023439-r04y1j22	711	35	ligands	ligand	NNS
cord-023439-r04y1j22	711	36	ranging	range	VBG
cord-023439-r04y1j22	711	37	from	from	IN
cord-023439-r04y1j22	711	38	strong	strong	JJ
cord-023439-r04y1j22	711	39	binders	binder	NNS
cord-023439-r04y1j22	711	40	We	-PRON-	PRP
cord-023439-r04y1j22	711	41	have	have	VBP
cord-023439-r04y1j22	711	42	previously	previously	RB
cord-023439-r04y1j22	711	43	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	711	44	that	that	IN
cord-023439-r04y1j22	711	45	bioinformatics	bioinformatics	NN
cord-023439-r04y1j22	711	46	tools	tool	NNS
cord-023439-r04y1j22	711	47	such	such	JJ
cord-023439-r04y1j22	711	48	as	as	IN
cord-023439-r04y1j22	711	49	artificial	artificial	JJ
cord-023439-r04y1j22	711	50	neural	neural	JJ
cord-023439-r04y1j22	711	51	networks	network	NNS
cord-023439-r04y1j22	711	52	(	(	-LRB-
cord-023439-r04y1j22	711	53	ANNs	ANNs	NNP
cord-023439-r04y1j22	711	54	)	)	-RRB-
cord-023439-r04y1j22	711	55	are	be	VBP
cord-023439-r04y1j22	711	56	capable	capable	JJ
cord-023439-r04y1j22	711	57	of	of	IN
cord-023439-r04y1j22	711	58	performing	perform	VBG
cord-023439-r04y1j22	711	59	pathogen-	pathogen-	NN
cord-023439-r04y1j22	711	60	,	,	,
cord-023439-r04y1j22	711	61	genome	genome	NN
cord-023439-r04y1j22	711	62	-	-	HYPH
cord-023439-r04y1j22	711	63	and	and	CC
cord-023439-r04y1j22	711	64	HLAwide	hlawide	NN
cord-023439-r04y1j22	711	65	predictions	prediction	NNS
cord-023439-r04y1j22	711	66	of	of	IN
cord-023439-r04y1j22	711	67	peptide	peptide	NN
cord-023439-r04y1j22	711	68	-	-	HYPH
cord-023439-r04y1j22	711	69	HLA	HLA	NNP
cord-023439-r04y1j22	711	70	interactions	interaction	NNS
cord-023439-r04y1j22	711	71	.	.	.
cord-023439-r04y1j22	712	1	These	these	DT
cord-023439-r04y1j22	712	2	tools	tool	NNS
cord-023439-r04y1j22	712	3	may	may	MD
cord-023439-r04y1j22	712	4	therefore	therefore	RB
cord-023439-r04y1j22	712	5	enable	enable	VB
cord-023439-r04y1j22	712	6	a	a	DT
cord-023439-r04y1j22	712	7	fast	fast	JJ
cord-023439-r04y1j22	712	8	and	and	CC
cord-023439-r04y1j22	712	9	rational	rational	JJ
cord-023439-r04y1j22	712	10	approach	approach	NN
cord-023439-r04y1j22	712	11	to	to	IN
cord-023439-r04y1j22	712	12	epitope	epitope	NN
cord-023439-r04y1j22	712	13	identification	identification	NN
cord-023439-r04y1j22	712	14	and	and	CC
cord-023439-r04y1j22	712	15	thereby	thereby	RB
cord-023439-r04y1j22	712	16	assist	assist	VB
cord-023439-r04y1j22	712	17	in	in	IN
cord-023439-r04y1j22	712	18	the	the	DT
cord-023439-r04y1j22	712	19	development	development	NN
cord-023439-r04y1j22	712	20	of	of	IN
cord-023439-r04y1j22	712	21	vaccines	vaccine	NNS
cord-023439-r04y1j22	712	22	and	and	CC
cord-023439-r04y1j22	712	23	immunotherapy	immunotherapy	NN
cord-023439-r04y1j22	712	24	.	.	.
cord-023439-r04y1j22	713	1	A	a	DT
cord-023439-r04y1j22	713	2	crucial	crucial	JJ
cord-023439-r04y1j22	713	3	step	step	NN
cord-023439-r04y1j22	713	4	in	in	IN
cord-023439-r04y1j22	713	5	the	the	DT
cord-023439-r04y1j22	713	6	generation	generation	NN
cord-023439-r04y1j22	713	7	of	of	IN
cord-023439-r04y1j22	713	8	such	such	JJ
cord-023439-r04y1j22	713	9	bioinformatics	bioinformatics	NN
cord-023439-r04y1j22	713	10	tools	tool	NNS
cord-023439-r04y1j22	713	11	is	be	VBZ
cord-023439-r04y1j22	713	12	the	the	DT
cord-023439-r04y1j22	713	13	selection	selection	NN
cord-023439-r04y1j22	713	14	of	of	IN
cord-023439-r04y1j22	713	15	data	datum	NNS
cord-023439-r04y1j22	713	16	representing	represent	VBG
cord-023439-r04y1j22	713	17	the	the	DT
cord-023439-r04y1j22	713	18	event	event	NN
cord-023439-r04y1j22	713	19	in	in	IN
cord-023439-r04y1j22	713	20	question	question	NN
cord-023439-r04y1j22	713	21	(	(	-LRB-
cord-023439-r04y1j22	713	22	in	in	IN
cord-023439-r04y1j22	713	23	casu	casu	NNP
cord-023439-r04y1j22	713	24	peptide	peptide	NNP
cord-023439-r04y1j22	713	25	-	-	HYPH
cord-023439-r04y1j22	713	26	HLA	HLA	NNP
cord-023439-r04y1j22	713	27	interaction	interaction	NN
cord-023439-r04y1j22	713	28	)	)	-RRB-
cord-023439-r04y1j22	713	29	.	.	.
cord-023439-r04y1j22	714	1	This	this	DT
cord-023439-r04y1j22	714	2	is	be	VBZ
cord-023439-r04y1j22	714	3	particularly	particularly	RB
cord-023439-r04y1j22	714	4	important	important	JJ
cord-023439-r04y1j22	714	5	when	when	WRB
cord-023439-r04y1j22	714	6	it	-PRON-	PRP
cord-023439-r04y1j22	714	7	is	be	VBZ
cord-023439-r04y1j22	714	8	difficult	difficult	JJ
cord-023439-r04y1j22	714	9	and	and	CC
cord-023439-r04y1j22	714	10	expensive	expensive	JJ
cord-023439-r04y1j22	714	11	to	to	TO
cord-023439-r04y1j22	714	12	obtain	obtain	VB
cord-023439-r04y1j22	714	13	data	datum	NNS
cord-023439-r04y1j22	714	14	.	.	.
cord-023439-r04y1j22	715	1	Herein	herein	RB
cord-023439-r04y1j22	715	2	,	,	,
cord-023439-r04y1j22	715	3	we	-PRON-	PRP
cord-023439-r04y1j22	715	4	demonstrate	demonstrate	VBP
cord-023439-r04y1j22	715	5	the	the	DT
cord-023439-r04y1j22	715	6	importance	importance	NN
cord-023439-r04y1j22	715	7	in	in	IN
cord-023439-r04y1j22	715	8	selecting	select	VBG
cord-023439-r04y1j22	715	9	information	information	NN
cord-023439-r04y1j22	715	10	-	-	HYPH
cord-023439-r04y1j22	715	11	rich	rich	JJ
cord-023439-r04y1j22	715	12	data	datum	NNS
cord-023439-r04y1j22	715	13	and	and	CC
cord-023439-r04y1j22	715	14	we	-PRON-	PRP
cord-023439-r04y1j22	715	15	develop	develop	VBP
cord-023439-r04y1j22	715	16	a	a	DT
cord-023439-r04y1j22	715	17	computational	computational	JJ
cord-023439-r04y1j22	715	18	method	method	NN
cord-023439-r04y1j22	715	19	,	,	,
cord-023439-r04y1j22	715	20	query	query	NN
cord-023439-r04y1j22	715	21	-	-	HYPH
cord-023439-r04y1j22	715	22	bycommittee	bycommittee	NNP
cord-023439-r04y1j22	715	23	,	,	,
cord-023439-r04y1j22	715	24	which	which	WDT
cord-023439-r04y1j22	715	25	can	can	MD
cord-023439-r04y1j22	715	26	perform	perform	VB
cord-023439-r04y1j22	715	27	a	a	DT
cord-023439-r04y1j22	715	28	global	global	JJ
cord-023439-r04y1j22	715	29	identification	identification	NN
cord-023439-r04y1j22	715	30	of	of	IN
cord-023439-r04y1j22	715	31	such	such	JJ
cord-023439-r04y1j22	715	32	information	information	NN
cord-023439-r04y1j22	715	33	-	-	HYPH
cord-023439-r04y1j22	715	34	rich	rich	JJ
cord-023439-r04y1j22	715	35	data	datum	NNS
cord-023439-r04y1j22	715	36	in	in	IN
cord-023439-r04y1j22	715	37	an	an	DT
cord-023439-r04y1j22	715	38	unbiased	unbiased	JJ
cord-023439-r04y1j22	715	39	and	and	CC
cord-023439-r04y1j22	715	40	automated	automated	JJ
cord-023439-r04y1j22	715	41	manner	manner	NN
cord-023439-r04y1j22	715	42	.	.	.
cord-023439-r04y1j22	716	1	Furthermore	furthermore	RB
cord-023439-r04y1j22	716	2	,	,	,
cord-023439-r04y1j22	716	3	we	-PRON-	PRP
cord-023439-r04y1j22	716	4	demonstrate	demonstrate	VBP
cord-023439-r04y1j22	716	5	how	how	WRB
cord-023439-r04y1j22	716	6	this	this	DT
cord-023439-r04y1j22	716	7	method	method	NN
cord-023439-r04y1j22	716	8	can	can	MD
cord-023439-r04y1j22	716	9	be	be	VB
cord-023439-r04y1j22	716	10	applied	apply	VBN
cord-023439-r04y1j22	716	11	to	to	IN
cord-023439-r04y1j22	716	12	an	an	DT
cord-023439-r04y1j22	716	13	efficient	efficient	JJ
cord-023439-r04y1j22	716	14	iterative	iterative	JJ
cord-023439-r04y1j22	716	15	development	development	NN
cord-023439-r04y1j22	716	16	strategy	strategy	NN
cord-023439-r04y1j22	716	17	for	for	IN
cord-023439-r04y1j22	716	18	these	these	DT
cord-023439-r04y1j22	716	19	bioinformatics	bioinformatics	NN
cord-023439-r04y1j22	716	20	tools	tool	NNS
cord-023439-r04y1j22	716	21	.	.	.
cord-023439-r04y1j22	717	1	Methods	method	NNS
cord-023439-r04y1j22	717	2	:	:	:
cord-023439-r04y1j22	718	1	A	a	DT
cord-023439-r04y1j22	718	2	large	large	JJ
cord-023439-r04y1j22	718	3	panel	panel	NN
cord-023439-r04y1j22	718	4	of	of	IN
cord-023439-r04y1j22	718	5	binding	bind	VBG
cord-023439-r04y1j22	718	6	affinities	affinity	NNS
cord-023439-r04y1j22	718	7	of	of	IN
cord-023439-r04y1j22	718	8	peptides	peptide	NNS
cord-023439-r04y1j22	718	9	binding	bind	VBG
cord-023439-r04y1j22	718	10	to	to	IN
cord-023439-r04y1j22	718	11	HLA	HLA	NNP
cord-023439-r04y1j22	718	12	A*0204	A*0204	NNP
cord-023439-r04y1j22	718	13	was	be	VBD
cord-023439-r04y1j22	718	14	measured	measure	VBN
cord-023439-r04y1j22	718	15	by	by	IN
cord-023439-r04y1j22	718	16	a	a	DT
cord-023439-r04y1j22	718	17	radioimmunoassay	radioimmunoassay	JJ
cord-023439-r04y1j22	718	18	(	(	-LRB-
cord-023439-r04y1j22	718	19	RIA	RIA	NNP
cord-023439-r04y1j22	718	20	)	)	-RRB-
cord-023439-r04y1j22	718	21	.	.	.
cord-023439-r04y1j22	719	1	This	this	DT
cord-023439-r04y1j22	719	2	data	data	NN
cord-023439-r04y1j22	719	3	was	be	VBD
cord-023439-r04y1j22	719	4	used	use	VBN
cord-023439-r04y1j22	719	5	to	to	TO
cord-023439-r04y1j22	719	6	develop	develop	VB
cord-023439-r04y1j22	719	7	multiple	multiple	JJ
cord-023439-r04y1j22	719	8	first	first	JJ
cord-023439-r04y1j22	719	9	generation	generation	NN
cord-023439-r04y1j22	719	10	ANNs	ANNs	NNP
cord-023439-r04y1j22	719	11	,	,	,
cord-023439-r04y1j22	719	12	which	which	WDT
cord-023439-r04y1j22	719	13	formed	form	VBD
cord-023439-r04y1j22	719	14	a	a	DT
cord-023439-r04y1j22	719	15	virtual	virtual	JJ
cord-023439-r04y1j22	719	16	committee	committee	NN
cord-023439-r04y1j22	719	17	.	.	.
cord-023439-r04y1j22	720	1	This	this	DT
cord-023439-r04y1j22	720	2	committee	committee	NN
cord-023439-r04y1j22	720	3	was	be	VBD
cord-023439-r04y1j22	720	4	used	use	VBN
cord-023439-r04y1j22	720	5	to	to	TO
cord-023439-r04y1j22	720	6	screen	screen	VB
cord-023439-r04y1j22	720	7	(	(	-LRB-
cord-023439-r04y1j22	720	8	or	or	CC
cord-023439-r04y1j22	720	9	'	'	``
cord-023439-r04y1j22	720	10	queried	query	VBN
cord-023439-r04y1j22	720	11	'	'	''
cord-023439-r04y1j22	720	12	)	)	-RRB-
cord-023439-r04y1j22	720	13	for	for	IN
cord-023439-r04y1j22	720	14	peptides	peptide	NNS
cord-023439-r04y1j22	720	15	,	,	,
cord-023439-r04y1j22	720	16	where	where	WRB
cord-023439-r04y1j22	720	17	the	the	DT
cord-023439-r04y1j22	720	18	ANNs	ANNs	NNP
cord-023439-r04y1j22	720	19	agreed	agree	VBD
cord-023439-r04y1j22	720	20	(	(	-LRB-
cord-023439-r04y1j22	720	21	'	'	``
cord-023439-r04y1j22	720	22	low	low	JJ
cord-023439-r04y1j22	720	23	-	-	HYPH
cord-023439-r04y1j22	720	24	QBC	QBC	NNP
cord-023439-r04y1j22	720	25	'	'	''
cord-023439-r04y1j22	720	26	)	)	-RRB-
cord-023439-r04y1j22	720	27	,	,	,
cord-023439-r04y1j22	720	28	or	or	CC
cord-023439-r04y1j22	720	29	disagreed	disagree	VBN
cord-023439-r04y1j22	720	30	(	(	-LRB-
cord-023439-r04y1j22	720	31	'	'	``
cord-023439-r04y1j22	720	32	high	high	JJ
cord-023439-r04y1j22	720	33	-	-	HYPH
cord-023439-r04y1j22	720	34	QBC	QBC	NNP
cord-023439-r04y1j22	720	35	'	'	''
cord-023439-r04y1j22	720	36	)	)	-RRB-
cord-023439-r04y1j22	720	37	,	,	,
cord-023439-r04y1j22	720	38	on	on	IN
cord-023439-r04y1j22	720	39	their	-PRON-	PRP$
cord-023439-r04y1j22	720	40	HLA	HLA	NNP
cord-023439-r04y1j22	720	41	-	-	HYPH
cord-023439-r04y1j22	720	42	binding	bind	VBG
cord-023439-r04y1j22	720	43	potential	potential	NN
cord-023439-r04y1j22	720	44	.	.	.
cord-023439-r04y1j22	721	1	Seventeen	seventeen	CD
cord-023439-r04y1j22	721	2	low	low	JJ
cord-023439-r04y1j22	721	3	-	-	HYPH
cord-023439-r04y1j22	721	4	QBC	QBC	NNP
cord-023439-r04y1j22	721	5	peptides	peptide	NNS
cord-023439-r04y1j22	721	6	and	and	CC
cord-023439-r04y1j22	721	7	17	17	CD
cord-023439-r04y1j22	721	8	high	high	JJ
cord-023439-r04y1j22	721	9	-	-	HYPH
cord-023439-r04y1j22	721	10	QBC	QBC	NNP
cord-023439-r04y1j22	721	11	peptides	peptide	NNS
cord-023439-r04y1j22	721	12	were	be	VBD
cord-023439-r04y1j22	721	13	synthesized	synthesize	VBN
cord-023439-r04y1j22	721	14	and	and	CC
cord-023439-r04y1j22	721	15	tested	test	VBN
cord-023439-r04y1j22	721	16	.	.	.
cord-023439-r04y1j22	722	1	The	the	DT
cord-023439-r04y1j22	722	2	high	high	JJ
cord-023439-r04y1j22	722	3	-	-	HYPH
cord-023439-r04y1j22	722	4	or	or	CC
cord-023439-r04y1j22	722	5	low	low	JJ
cord-023439-r04y1j22	722	6	-	-	HYPH
cord-023439-r04y1j22	722	7	QBC	QBC	NNP
cord-023439-r04y1j22	722	8	data	datum	NNS
cord-023439-r04y1j22	722	9	were	be	VBD
cord-023439-r04y1j22	722	10	added	add	VBN
cord-023439-r04y1j22	722	11	to	to	IN
cord-023439-r04y1j22	722	12	the	the	DT
cord-023439-r04y1j22	722	13	original	original	JJ
cord-023439-r04y1j22	722	14	data	datum	NNS
cord-023439-r04y1j22	722	15	,	,	,
cord-023439-r04y1j22	722	16	and	and	CC
cord-023439-r04y1j22	722	17	new	new	JJ
cord-023439-r04y1j22	722	18	high	high	JJ
cord-023439-r04y1j22	722	19	-	-	HYPH
cord-023439-r04y1j22	722	20	or	or	CC
cord-023439-r04y1j22	722	21	low	low	JJ
cord-023439-r04y1j22	722	22	-	-	HYPH
cord-023439-r04y1j22	722	23	QBC	QBC	NNP
cord-023439-r04y1j22	722	24	second	second	JJ
cord-023439-r04y1j22	722	25	generation	generation	NN
cord-023439-r04y1j22	722	26	ANNs	ANNs	NNPS
cord-023439-r04y1j22	722	27	were	be	VBD
cord-023439-r04y1j22	722	28	developed	develop	VBN
cord-023439-r04y1j22	722	29	,	,	,
cord-023439-r04y1j22	722	30	respectively	respectively	RB
cord-023439-r04y1j22	722	31	.	.	.
cord-023439-r04y1j22	723	1	This	this	DT
cord-023439-r04y1j22	723	2	procedure	procedure	NN
cord-023439-r04y1j22	723	3	was	be	VBD
cord-023439-r04y1j22	723	4	repeated	repeat	VBN
cord-023439-r04y1j22	723	5	40	40	CD
cord-023439-r04y1j22	723	6	times	time	NNS
cord-023439-r04y1j22	723	7	.	.	.
cord-023439-r04y1j22	724	1	The	the	DT
cord-023439-r04y1j22	724	2	high	high	JJ
cord-023439-r04y1j22	724	3	-	-	HYPH
cord-023439-r04y1j22	724	4	QBC	qbc	NN
cord-023439-r04y1j22	724	5	-	-	HYPH
cord-023439-r04y1j22	724	6	enriched	enrich	VBN
cord-023439-r04y1j22	724	7	ANN	ANN	NNP
cord-023439-r04y1j22	724	8	performed	perform	VBD
cord-023439-r04y1j22	724	9	significantly	significantly	RB
cord-023439-r04y1j22	724	10	better	well	RBR
cord-023439-r04y1j22	724	11	than	than	IN
cord-023439-r04y1j22	724	12	the	the	DT
cord-023439-r04y1j22	724	13	low	low	JJ
cord-023439-r04y1j22	724	14	-	-	HYPH
cord-023439-r04y1j22	724	15	QBC	qbc	NN
cord-023439-r04y1j22	724	16	-	-	HYPH
cord-023439-r04y1j22	724	17	enriched	enrich	VBN
cord-023439-r04y1j22	724	18	ANN	ANN	NNP
cord-023439-r04y1j22	724	19	in	in	IN
cord-023439-r04y1j22	724	20	37	37	CD
cord-023439-r04y1j22	724	21	of	of	IN
cord-023439-r04y1j22	724	22	the	the	DT
cord-023439-r04y1j22	724	23	40	40	CD
cord-023439-r04y1j22	724	24	tests	test	NNS
cord-023439-r04y1j22	724	25	.	.	.
cord-023439-r04y1j22	725	1	Conclusion	conclusion	NN
cord-023439-r04y1j22	725	2	:	:	:
cord-023439-r04y1j22	726	1	These	these	DT
cord-023439-r04y1j22	726	2	results	result	NNS
cord-023439-r04y1j22	726	3	demonstrate	demonstrate	VBP
cord-023439-r04y1j22	726	4	that	that	IN
cord-023439-r04y1j22	726	5	high	high	JJ
cord-023439-r04y1j22	726	6	-	-	HYPH
cord-023439-r04y1j22	726	7	QBCenriched	qbcenriched	NN
cord-023439-r04y1j22	726	8	networks	network	NNS
cord-023439-r04y1j22	726	9	perform	perform	VBP
cord-023439-r04y1j22	726	10	better	well	JJR
cord-023439-r04y1j22	726	11	than	than	IN
cord-023439-r04y1j22	726	12	low	low	JJ
cord-023439-r04y1j22	726	13	-	-	HYPH
cord-023439-r04y1j22	726	14	QBC	qbc	NN
cord-023439-r04y1j22	726	15	-	-	HYPH
cord-023439-r04y1j22	726	16	enriched	enrich	VBN
cord-023439-r04y1j22	726	17	networks	network	NNS
cord-023439-r04y1j22	726	18	in	in	IN
cord-023439-r04y1j22	726	19	selecting	select	VBG
cord-023439-r04y1j22	726	20	informative	informative	JJ
cord-023439-r04y1j22	726	21	data	datum	NNS
cord-023439-r04y1j22	726	22	for	for	IN
cord-023439-r04y1j22	726	23	developing	develop	VBG
cord-023439-r04y1j22	726	24	peptide	peptide	JJ
cord-023439-r04y1j22	726	25	-	-	HYPH
cord-023439-r04y1j22	726	26	MHC	MHC	NNP
cord-023439-r04y1j22	726	27	-	-	HYPH
cord-023439-r04y1j22	726	28	binding	bind	VBG
cord-023439-r04y1j22	726	29	predictors	predictor	NNS
cord-023439-r04y1j22	726	30	.	.	.
cord-023439-r04y1j22	727	1	This	this	DT
cord-023439-r04y1j22	727	2	improvement	improvement	NN
cord-023439-r04y1j22	727	3	in	in	IN
cord-023439-r04y1j22	727	4	selecting	select	VBG
cord-023439-r04y1j22	727	5	data	datum	NNS
cord-023439-r04y1j22	727	6	is	be	VBZ
cord-023439-r04y1j22	727	7	not	not	RB
cord-023439-r04y1j22	727	8	due	due	JJ
cord-023439-r04y1j22	727	9	to	to	IN
cord-023439-r04y1j22	727	10	differences	difference	NNS
cord-023439-r04y1j22	727	11	in	in	IN
cord-023439-r04y1j22	727	12	network	network	NN
cord-023439-r04y1j22	727	13	training	training	NN
cord-023439-r04y1j22	727	14	performance	performance	NN
cord-023439-r04y1j22	727	15	but	but	CC
cord-023439-r04y1j22	727	16	due	due	IN
cord-023439-r04y1j22	727	17	to	to	IN
cord-023439-r04y1j22	727	18	the	the	DT
cord-023439-r04y1j22	727	19	difference	difference	NN
cord-023439-r04y1j22	727	20	in	in	IN
cord-023439-r04y1j22	727	21	information	information	NN
cord-023439-r04y1j22	727	22	content	content	NN
cord-023439-r04y1j22	727	23	in	in	IN
cord-023439-r04y1j22	727	24	the	the	DT
cord-023439-r04y1j22	727	25	high	high	JJ
cord-023439-r04y1j22	727	26	-	-	HYPH
cord-023439-r04y1j22	727	27	QBC	QBC	NNP
cord-023439-r04y1j22	727	28	experiment	experiment	NN
cord-023439-r04y1j22	727	29	and	and	CC
cord-023439-r04y1j22	727	30	in	in	IN
cord-023439-r04y1j22	727	31	the	the	DT
cord-023439-r04y1j22	727	32	low	low	JJ
cord-023439-r04y1j22	727	33	-	-	HYPH
cord-023439-r04y1j22	727	34	QBC	QBC	NNP
cord-023439-r04y1j22	727	35	experiment	experiment	NN
cord-023439-r04y1j22	727	36	.	.	.
cord-023439-r04y1j22	728	1	Finally	finally	RB
cord-023439-r04y1j22	728	2	,	,	,
cord-023439-r04y1j22	728	3	it	-PRON-	PRP
cord-023439-r04y1j22	728	4	should	should	MD
cord-023439-r04y1j22	728	5	be	be	VB
cord-023439-r04y1j22	728	6	noted	note	VBN
cord-023439-r04y1j22	728	7	that	that	IN
cord-023439-r04y1j22	728	8	this	this	DT
cord-023439-r04y1j22	728	9	strategy	strategy	NN
cord-023439-r04y1j22	728	10	could	could	MD
cord-023439-r04y1j22	728	11	be	be	VB
cord-023439-r04y1j22	728	12	used	use	VBN
cord-023439-r04y1j22	728	13	in	in	IN
cord-023439-r04y1j22	728	14	many	many	JJ
cord-023439-r04y1j22	728	15	contexts	context	NNS
cord-023439-r04y1j22	728	16	where	where	WRB
cord-023439-r04y1j22	728	17	generation	generation	NN
cord-023439-r04y1j22	728	18	of	of	IN
cord-023439-r04y1j22	728	19	data	datum	NNS
cord-023439-r04y1j22	728	20	is	be	VBZ
cord-023439-r04y1j22	728	21	difficult	difficult	JJ
cord-023439-r04y1j22	728	22	and	and	CC
cord-023439-r04y1j22	728	23	costly	costly	JJ
cord-023439-r04y1j22	728	24	.	.	.
cord-023439-r04y1j22	729	1	Interleukin-18	Interleukin-18	NNP
cord-023439-r04y1j22	729	2	(	(	-LRB-
cord-023439-r04y1j22	729	3	IL-18	IL-18	NNP
cord-023439-r04y1j22	729	4	)	)	-RRB-
cord-023439-r04y1j22	729	5	,	,	,
cord-023439-r04y1j22	729	6	a	a	DT
cord-023439-r04y1j22	729	7	pro	pro	JJ
cord-023439-r04y1j22	729	8	-	-	JJ
cord-023439-r04y1j22	729	9	inflammatory	inflammatory	JJ
cord-023439-r04y1j22	729	10	cytokine	cytokine	NN
cord-023439-r04y1j22	729	11	that	that	WDT
cord-023439-r04y1j22	729	12	is	be	VBZ
cord-023439-r04y1j22	729	13	produced	produce	VBN
cord-023439-r04y1j22	729	14	by	by	IN
cord-023439-r04y1j22	729	15	both	both	DT
cord-023439-r04y1j22	729	16	lymphoid	lymphoid	NNP
cord-023439-r04y1j22	729	17	and	and	CC
cord-023439-r04y1j22	729	18	nonlymphoid	nonlymphoid	NNP
cord-023439-r04y1j22	729	19	cells	cell	NNS
cord-023439-r04y1j22	729	20	,	,	,
cord-023439-r04y1j22	729	21	has	have	VBZ
cord-023439-r04y1j22	729	22	a	a	DT
cord-023439-r04y1j22	729	23	critical	critical	JJ
cord-023439-r04y1j22	729	24	role	role	NN
cord-023439-r04y1j22	729	25	in	in	IN
cord-023439-r04y1j22	729	26	modulation	modulation	NN
cord-023439-r04y1j22	729	27	of	of	IN
cord-023439-r04y1j22	729	28	innate	innate	JJ
cord-023439-r04y1j22	729	29	and	and	CC
cord-023439-r04y1j22	729	30	adaptive	adaptive	JJ
cord-023439-r04y1j22	729	31	immunity	immunity	NN
cord-023439-r04y1j22	729	32	.	.	.
cord-023439-r04y1j22	730	1	Its	-PRON-	PRP$
cord-023439-r04y1j22	730	2	primary	primary	JJ
cord-023439-r04y1j22	730	3	function	function	NN
cord-023439-r04y1j22	730	4	in	in	IN
cord-023439-r04y1j22	730	5	stimulation	stimulation	NN
cord-023439-r04y1j22	730	6	of	of	IN
cord-023439-r04y1j22	730	7	IFN	IFN	NNP
cord-023439-r04y1j22	730	8	-	-	HYPH
cord-023439-r04y1j22	730	9	g	g	NN
cord-023439-r04y1j22	730	10	production	production	NN
cord-023439-r04y1j22	730	11	and	and	CC
cord-023439-r04y1j22	730	12	stimulation	stimulation	NN
cord-023439-r04y1j22	730	13	of	of	IN
cord-023439-r04y1j22	730	14	NK	nk	NN
cord-023439-r04y1j22	730	15	-	-	HYPH
cord-023439-r04y1j22	730	16	cell	cell	NN
cord-023439-r04y1j22	730	17	-	-	HYPH
cord-023439-r04y1j22	730	18	cytotoxic	cytotoxic	JJ
cord-023439-r04y1j22	730	19	activities	activity	NNS
cord-023439-r04y1j22	730	20	makes	make	VBZ
cord-023439-r04y1j22	730	21	this	this	DT
cord-023439-r04y1j22	730	22	cytokine	cytokine	NN
cord-023439-r04y1j22	730	23	a	a	DT
cord-023439-r04y1j22	730	24	candidate	candidate	NN
cord-023439-r04y1j22	730	25	for	for	IN
cord-023439-r04y1j22	730	26	cancer	cancer	NN
cord-023439-r04y1j22	730	27	immunotherapy	immunotherapy	NN
cord-023439-r04y1j22	730	28	.	.	.
cord-023439-r04y1j22	731	1	In	in	IN
cord-023439-r04y1j22	731	2	oral	oral	JJ
cord-023439-r04y1j22	731	3	cavity	cavity	NN
cord-023439-r04y1j22	731	4	,	,	,
cord-023439-r04y1j22	731	5	this	this	DT
cord-023439-r04y1j22	731	6	cytokine	cytokine	NN
cord-023439-r04y1j22	731	7	is	be	VBZ
cord-023439-r04y1j22	731	8	produced	produce	VBN
cord-023439-r04y1j22	731	9	by	by	IN
cord-023439-r04y1j22	731	10	oral	oral	JJ
cord-023439-r04y1j22	731	11	epithelia	epithelium	NNS
cord-023439-r04y1j22	731	12	and	and	CC
cord-023439-r04y1j22	731	13	carcinoma	carcinoma	NN
cord-023439-r04y1j22	731	14	cells	cell	NNS
cord-023439-r04y1j22	731	15	and	and	CC
cord-023439-r04y1j22	731	16	is	be	VBZ
cord-023439-r04y1j22	731	17	related	relate	VBN
cord-023439-r04y1j22	731	18	to	to	IN
cord-023439-r04y1j22	731	19	tumour	tumour	NN
cord-023439-r04y1j22	731	20	regression	regression	NN
cord-023439-r04y1j22	731	21	in	in	IN
cord-023439-r04y1j22	731	22	nude	nude	JJ
cord-023439-r04y1j22	731	23	mice	mouse	NNS
cord-023439-r04y1j22	731	24	bearing	bear	VBG
cord-023439-r04y1j22	731	25	salivary	salivary	JJ
cord-023439-r04y1j22	731	26	adenocarcinoma	adenocarcinoma	NN
cord-023439-r04y1j22	731	27	.	.	.
cord-023439-r04y1j22	732	1	However	however	RB
cord-023439-r04y1j22	732	2	,	,	,
cord-023439-r04y1j22	732	3	direct	direct	JJ
cord-023439-r04y1j22	732	4	effects	effect	NNS
cord-023439-r04y1j22	732	5	of	of	IN
cord-023439-r04y1j22	732	6	this	this	DT
cord-023439-r04y1j22	732	7	cytokine	cytokine	NN
cord-023439-r04y1j22	732	8	on	on	IN
cord-023439-r04y1j22	732	9	oral	oral	JJ
cord-023439-r04y1j22	732	10	cancer	cancer	NN
cord-023439-r04y1j22	732	11	cells	cell	NNS
cord-023439-r04y1j22	732	12	have	have	VBP
cord-023439-r04y1j22	732	13	not	not	RB
cord-023439-r04y1j22	732	14	been	be	VBN
cord-023439-r04y1j22	732	15	elucidated	elucidate	VBN
cord-023439-r04y1j22	732	16	.	.	.
cord-023439-r04y1j22	733	1	In	in	IN
cord-023439-r04y1j22	733	2	this	this	DT
cord-023439-r04y1j22	733	3	project	project	NN
cord-023439-r04y1j22	733	4	,	,	,
cord-023439-r04y1j22	733	5	we	-PRON-	PRP
cord-023439-r04y1j22	733	6	investigated	investigate	VBD
cord-023439-r04y1j22	733	7	IL-18	IL-18	NNP
cord-023439-r04y1j22	733	8	effect	effect	NN
cord-023439-r04y1j22	733	9	on	on	IN
cord-023439-r04y1j22	733	10	an	an	DT
cord-023439-r04y1j22	733	11	oral	oral	JJ
cord-023439-r04y1j22	733	12	carcinoma	carcinoma	NN
cord-023439-r04y1j22	733	13	(	(	-LRB-
cord-023439-r04y1j22	733	14	KB	KB	NNP
cord-023439-r04y1j22	733	15	)	)	-RRB-
cord-023439-r04y1j22	733	16	cell	cell	NN
cord-023439-r04y1j22	733	17	line	line	NN
cord-023439-r04y1j22	733	18	.	.	.
cord-023439-r04y1j22	734	1	With	with	IN
cord-023439-r04y1j22	734	2	RT	RT	NNP
cord-023439-r04y1j22	734	3	-	-	HYPH
cord-023439-r04y1j22	734	4	PCR	PCR	NNP
cord-023439-r04y1j22	734	5	technique	technique	NN
cord-023439-r04y1j22	734	6	,	,	,
cord-023439-r04y1j22	734	7	KB	kb	NN
cord-023439-r04y1j22	734	8	-	-	HYPH
cord-023439-r04y1j22	734	9	cell	cell	NN
cord-023439-r04y1j22	734	10	line	line	NN
cord-023439-r04y1j22	734	11	was	be	VBD
cord-023439-r04y1j22	734	12	found	find	VBN
cord-023439-r04y1j22	734	13	to	to	TO
cord-023439-r04y1j22	734	14	express	express	VB
cord-023439-r04y1j22	734	15	IL-18	IL-18	NNP
cord-023439-r04y1j22	734	16	receptors	receptor	NNS
cord-023439-r04y1j22	734	17	(	(	-LRB-
cord-023439-r04y1j22	734	18	IL-18Ra	IL-18Ra	NNP
cord-023439-r04y1j22	734	19	and	and	CC
cord-023439-r04y1j22	734	20	IL-18Rb	IL-18Rb	NNP
cord-023439-r04y1j22	734	21	)	)	-RRB-
cord-023439-r04y1j22	734	22	,	,	,
cord-023439-r04y1j22	734	23	indicating	indicate	VBG
cord-023439-r04y1j22	734	24	that	that	IN
cord-023439-r04y1j22	734	25	this	this	DT
cord-023439-r04y1j22	734	26	oral	oral	JJ
cord-023439-r04y1j22	734	27	carcinoma	carcinoma	NN
cord-023439-r04y1j22	734	28	line	line	NN
cord-023439-r04y1j22	734	29	is	be	VBZ
cord-023439-r04y1j22	734	30	a	a	DT
cord-023439-r04y1j22	734	31	target	target	NN
cord-023439-r04y1j22	734	32	for	for	IN
cord-023439-r04y1j22	734	33	IL-18	IL-18	NNP
cord-023439-r04y1j22	734	34	study	study	NN
cord-023439-r04y1j22	734	35	.	.	.
cord-023439-r04y1j22	735	1	We	-PRON-	PRP
cord-023439-r04y1j22	735	2	showed	show	VBD
cord-023439-r04y1j22	735	3	that	that	IN
cord-023439-r04y1j22	735	4	recombinant	recombinant	JJ
cord-023439-r04y1j22	735	5	human	human	NN
cord-023439-r04y1j22	735	6	IL-18	IL-18	NNP
cord-023439-r04y1j22	735	7	inhibited	inhibited	JJ
cord-023439-r04y1j22	735	8	KB	KB	NNP
cord-023439-r04y1j22	735	9	-	-	HYPH
cord-023439-r04y1j22	735	10	cell	cell	NN
cord-023439-r04y1j22	735	11	proliferation	proliferation	NN
cord-023439-r04y1j22	735	12	by	by	IN
cord-023439-r04y1j22	735	13	17	17	CD
cord-023439-r04y1j22	735	14	%	%	NN
cord-023439-r04y1j22	735	15	at	at	IN
cord-023439-r04y1j22	735	16	concentration	concentration	NN
cord-023439-r04y1j22	735	17	of	of	IN
cord-023439-r04y1j22	735	18	100	100	CD
cord-023439-r04y1j22	735	19	ng	ng	NN
cord-023439-r04y1j22	735	20	/	/	SYM
cord-023439-r04y1j22	735	21	ml	ml	NN
cord-023439-r04y1j22	735	22	(	(	-LRB-
cord-023439-r04y1j22	735	23	P	p	NN
cord-023439-r04y1j22	735	24	<	<	XX
cord-023439-r04y1j22	735	25	0.05	0.05	CD
cord-023439-r04y1j22	735	26	)	)	-RRB-
cord-023439-r04y1j22	735	27	,	,	,
cord-023439-r04y1j22	735	28	whereas	whereas	IN
cord-023439-r04y1j22	735	29	LDH	LDH	NNP
cord-023439-r04y1j22	735	30	release	release	NN
cord-023439-r04y1j22	735	31	by	by	IN
cord-023439-r04y1j22	735	32	these	these	DT
cord-023439-r04y1j22	735	33	cells	cell	NNS
cord-023439-r04y1j22	735	34	in	in	IN
cord-023439-r04y1j22	735	35	treatment	treatment	NN
cord-023439-r04y1j22	735	36	group	group	NN
cord-023439-r04y1j22	735	37	and	and	CC
cord-023439-r04y1j22	735	38	control	control	NN
cord-023439-r04y1j22	735	39	groups	group	NNS
cord-023439-r04y1j22	735	40	was	be	VBD
cord-023439-r04y1j22	735	41	comparable	comparable	JJ
cord-023439-r04y1j22	735	42	,	,	,
cord-023439-r04y1j22	735	43	indicating	indicate	VBG
cord-023439-r04y1j22	735	44	that	that	IN
cord-023439-r04y1j22	735	45	IL-18	IL-18	NNP
cord-023439-r04y1j22	735	46	suppression	suppression	NN
cord-023439-r04y1j22	735	47	of	of	IN
cord-023439-r04y1j22	735	48	cell	cell	NN
cord-023439-r04y1j22	735	49	proliferation	proliferation	NN
cord-023439-r04y1j22	735	50	was	be	VBD
cord-023439-r04y1j22	735	51	not	not	RB
cord-023439-r04y1j22	735	52	mediated	mediate	VBN
cord-023439-r04y1j22	735	53	by	by	IN
cord-023439-r04y1j22	735	54	the	the	DT
cord-023439-r04y1j22	735	55	induction	induction	NN
cord-023439-r04y1j22	735	56	of	of	IN
cord-023439-r04y1j22	735	57	cell	cell	NN
cord-023439-r04y1j22	735	58	death	death	NN
cord-023439-r04y1j22	735	59	.	.	.
cord-023439-r04y1j22	736	1	To	to	TO
cord-023439-r04y1j22	736	2	further	further	RB
cord-023439-r04y1j22	736	3	address	address	VB
cord-023439-r04y1j22	736	4	this	this	DT
cord-023439-r04y1j22	736	5	hypothesis	hypothesis	NN
cord-023439-r04y1j22	736	6	,	,	,
cord-023439-r04y1j22	736	7	we	-PRON-	PRP
cord-023439-r04y1j22	736	8	found	find	VBD
cord-023439-r04y1j22	736	9	that	that	IN
cord-023439-r04y1j22	736	10	IL-18	IL-18	NNP
cord-023439-r04y1j22	736	11	treatment	treatment	NN
cord-023439-r04y1j22	736	12	did	do	VBD
cord-023439-r04y1j22	736	13	not	not	RB
cord-023439-r04y1j22	736	14	induce	induce	VB
cord-023439-r04y1j22	736	15	apoptotic	apoptotic	JJ
cord-023439-r04y1j22	736	16	cell	cell	NN
cord-023439-r04y1j22	736	17	death	death	NN
cord-023439-r04y1j22	736	18	,	,	,
cord-023439-r04y1j22	736	19	as	as	IN
cord-023439-r04y1j22	736	20	studied	study	VBN
cord-023439-r04y1j22	736	21	by	by	IN
cord-023439-r04y1j22	736	22	DNA	dna	NN
cord-023439-r04y1j22	736	23	laddering	laddering	NN
cord-023439-r04y1j22	736	24	and	and	CC
cord-023439-r04y1j22	736	25	TUNEL	TUNEL	NNP
cord-023439-r04y1j22	736	26	assays	assay	NNS
cord-023439-r04y1j22	736	27	.	.	.
cord-023439-r04y1j22	737	1	In	in	IN
cord-023439-r04y1j22	737	2	addition	addition	NN
cord-023439-r04y1j22	737	3	,	,	,
cord-023439-r04y1j22	737	4	expression	expression	NN
cord-023439-r04y1j22	737	5	pattern	pattern	NN
cord-023439-r04y1j22	737	6	of	of	IN
cord-023439-r04y1j22	737	7	cell	cell	NN
cord-023439-r04y1j22	737	8	death	death	NN
cord-023439-r04y1j22	737	9	-	-	HYPH
cord-023439-r04y1j22	737	10	controlling	control	VBG
cord-023439-r04y1j22	737	11	genes	gene	NNS
cord-023439-r04y1j22	737	12	(	(	-LRB-
cord-023439-r04y1j22	737	13	bcl-2	bcl-2	NNP
cord-023439-r04y1j22	737	14	and	and	CC
cord-023439-r04y1j22	737	15	bax	bax	NNP
cord-023439-r04y1j22	737	16	)	)	-RRB-
cord-023439-r04y1j22	737	17	was	be	VBD
cord-023439-r04y1j22	737	18	not	not	RB
cord-023439-r04y1j22	737	19	altered	alter	VBN
cord-023439-r04y1j22	737	20	by	by	IN
cord-023439-r04y1j22	737	21	this	this	DT
cord-023439-r04y1j22	737	22	cytokine	cytokine	NN
cord-023439-r04y1j22	737	23	.	.	.
cord-023439-r04y1j22	738	1	Findings	finding	NNS
cord-023439-r04y1j22	738	2	in	in	IN
cord-023439-r04y1j22	738	3	these	these	DT
cord-023439-r04y1j22	738	4	studies	study	NNS
cord-023439-r04y1j22	738	5	indicated	indicate	VBD
cord-023439-r04y1j22	738	6	that	that	IN
cord-023439-r04y1j22	738	7	suppression	suppression	NN
cord-023439-r04y1j22	738	8	of	of	IN
cord-023439-r04y1j22	738	9	KB	kb	NN
cord-023439-r04y1j22	738	10	-	-	HYPH
cord-023439-r04y1j22	738	11	cell	cell	NN
cord-023439-r04y1j22	738	12	proliferation	proliferation	NN
cord-023439-r04y1j22	738	13	may	may	MD
cord-023439-r04y1j22	738	14	be	be	VB
cord-023439-r04y1j22	738	15	attributed	attribute	VBN
cord-023439-r04y1j22	738	16	to	to	IN
cord-023439-r04y1j22	738	17	control	control	NN
cord-023439-r04y1j22	738	18	of	of	IN
cord-023439-r04y1j22	738	19	cell	cell	NN
cord-023439-r04y1j22	738	20	cycle	cycle	NN
cord-023439-r04y1j22	738	21	,	,	,
cord-023439-r04y1j22	738	22	growth	growth	NN
cord-023439-r04y1j22	738	23	arrest	arrest	NN
cord-023439-r04y1j22	738	24	or	or	CC
cord-023439-r04y1j22	738	25	induction	induction	NN
cord-023439-r04y1j22	738	26	of	of	IN
cord-023439-r04y1j22	738	27	cell	cell	NN
cord-023439-r04y1j22	738	28	differentiation	differentiation	NN
cord-023439-r04y1j22	738	29	.	.	.
cord-023439-r04y1j22	739	1	The	the	DT
cord-023439-r04y1j22	739	2	data	datum	NNS
cord-023439-r04y1j22	739	3	presented	present	VBN
cord-023439-r04y1j22	739	4	in	in	IN
cord-023439-r04y1j22	739	5	this	this	DT
cord-023439-r04y1j22	739	6	project	project	NN
cord-023439-r04y1j22	739	7	could	could	MD
cord-023439-r04y1j22	739	8	provide	provide	VB
cord-023439-r04y1j22	739	9	an	an	DT
cord-023439-r04y1j22	739	10	insight	insight	NN
cord-023439-r04y1j22	739	11	of	of	IN
cord-023439-r04y1j22	739	12	how	how	WRB
cord-023439-r04y1j22	739	13	cancer	cancer	NN
cord-023439-r04y1j22	739	14	cell	cell	NN
cord-023439-r04y1j22	739	15	directly	directly	RB
cord-023439-r04y1j22	739	16	responds	respond	VBZ
cord-023439-r04y1j22	739	17	to	to	IN
cord-023439-r04y1j22	739	18	IL-18	IL-18	NNP
cord-023439-r04y1j22	739	19	,	,	,
cord-023439-r04y1j22	739	20	as	as	IN
cord-023439-r04y1j22	739	21	this	this	DT
cord-023439-r04y1j22	739	22	cytokine	cytokine	NN
cord-023439-r04y1j22	739	23	is	be	VBZ
cord-023439-r04y1j22	739	24	an	an	DT
cord-023439-r04y1j22	739	25	important	important	JJ
cord-023439-r04y1j22	739	26	regulator	regulator	NN
cord-023439-r04y1j22	739	27	of	of	IN
cord-023439-r04y1j22	739	28	anticancer	anticancer	JJ
cord-023439-r04y1j22	739	29	mechanisms	mechanism	NNS
cord-023439-r04y1j22	739	30	.	.	.
cord-023439-r04y1j22	740	1	Aloe	aloe	NN
cord-023439-r04y1j22	740	2	emodin	emodin	NNS
cord-023439-r04y1j22	740	3	(	(	-LRB-
cord-023439-r04y1j22	740	4	AE	AE	NNP
cord-023439-r04y1j22	740	5	)	)	-RRB-
cord-023439-r04y1j22	740	6	is	be	VBZ
cord-023439-r04y1j22	740	7	a	a	DT
cord-023439-r04y1j22	740	8	naturally	naturally	RB
cord-023439-r04y1j22	740	9	occurring	occur	VBG
cord-023439-r04y1j22	740	10	compound	compound	NN
cord-023439-r04y1j22	740	11	with	with	IN
cord-023439-r04y1j22	740	12	wide	wide	JJ
cord-023439-r04y1j22	740	13	spectrum	spectrum	NN
cord-023439-r04y1j22	740	14	of	of	IN
cord-023439-r04y1j22	740	15	biological	biological	JJ
cord-023439-r04y1j22	740	16	properties	property	NNS
cord-023439-r04y1j22	740	17	,	,	,
cord-023439-r04y1j22	740	18	including	include	VBG
cord-023439-r04y1j22	740	19	antimicrobial	antimicrobial	JJ
cord-023439-r04y1j22	740	20	,	,	,
cord-023439-r04y1j22	740	21	vasorelaxant	vasorelaxant	JJ
cord-023439-r04y1j22	740	22	,	,	,
cord-023439-r04y1j22	740	23	immunosuppressive	immunosuppressive	JJ
cord-023439-r04y1j22	740	24	and	and	CC
cord-023439-r04y1j22	740	25	anticancer	anticancer	JJ
cord-023439-r04y1j22	740	26	actions	action	NNS
cord-023439-r04y1j22	740	27	.	.	.
cord-023439-r04y1j22	741	1	This	this	DT
cord-023439-r04y1j22	741	2	anthraquinone	anthraquinone	NN
cord-023439-r04y1j22	741	3	induces	induce	VBZ
cord-023439-r04y1j22	741	4	apoptosis	apoptosis	NN
cord-023439-r04y1j22	741	5	in	in	IN
cord-023439-r04y1j22	741	6	several	several	JJ
cord-023439-r04y1j22	741	7	tumour	tumour	NN
cord-023439-r04y1j22	741	8	cell	cell	NN
cord-023439-r04y1j22	741	9	lines	line	NNS
cord-023439-r04y1j22	741	10	with	with	IN
cord-023439-r04y1j22	741	11	special	special	JJ
cord-023439-r04y1j22	741	12	affinity	affinity	NN
cord-023439-r04y1j22	741	13	to	to	IN
cord-023439-r04y1j22	741	14	tumours	tumour	NNS
cord-023439-r04y1j22	741	15	of	of	IN
cord-023439-r04y1j22	741	16	neuroectodermal	neuroectodermal	JJ
cord-023439-r04y1j22	741	17	origin	origin	NN
cord-023439-r04y1j22	741	18	.	.	.
cord-023439-r04y1j22	742	1	High	high	JJ
cord-023439-r04y1j22	742	2	amounts	amount	NNS
cord-023439-r04y1j22	742	3	of	of	IN
cord-023439-r04y1j22	742	4	nitric	nitric	NN
cord-023439-r04y1j22	742	5	oxide	oxide	NN
cord-023439-r04y1j22	742	6	(	(	-LRB-
cord-023439-r04y1j22	742	7	NO	no	RB
cord-023439-r04y1j22	742	8	)	)	-RRB-
cord-023439-r04y1j22	742	9	released	release	VBN
cord-023439-r04y1j22	742	10	by	by	IN
cord-023439-r04y1j22	742	11	activated	activate	VBN
cord-023439-r04y1j22	742	12	macrophages	macrophage	NNS
cord-023439-r04y1j22	742	13	induce	induce	VBP
cord-023439-r04y1j22	742	14	tumour	tumour	NN
cord-023439-r04y1j22	742	15	cell	cell	NN
cord-023439-r04y1j22	742	16	death	death	NN
cord-023439-r04y1j22	742	17	.	.	.
cord-023439-r04y1j22	743	1	Therefore	therefore	RB
cord-023439-r04y1j22	743	2	,	,	,
cord-023439-r04y1j22	743	3	we	-PRON-	PRP
cord-023439-r04y1j22	743	4	explored	explore	VBD
cord-023439-r04y1j22	743	5	the	the	DT
cord-023439-r04y1j22	743	6	capacity	capacity	NN
cord-023439-r04y1j22	743	7	of	of	IN
cord-023439-r04y1j22	743	8	AE	AE	NNP
cord-023439-r04y1j22	743	9	to	to	TO
cord-023439-r04y1j22	743	10	modulate	modulate	VB
cord-023439-r04y1j22	743	11	NO	no	RB
cord-023439-r04y1j22	743	12	-	-	HYPH
cord-023439-r04y1j22	743	13	mediated	mediate	VBN
cord-023439-r04y1j22	743	14	antitumour	antitumour	JJ
cord-023439-r04y1j22	743	15	response	response	NN
cord-023439-r04y1j22	743	16	in	in	IN
cord-023439-r04y1j22	743	17	vitro	vitro	FW
cord-023439-r04y1j22	743	18	.	.	.
cord-023439-r04y1j22	744	1	Interestingly	interestingly	RB
cord-023439-r04y1j22	744	2	,	,	,
cord-023439-r04y1j22	744	3	while	while	IN
cord-023439-r04y1j22	744	4	AE	AE	NNP
cord-023439-r04y1j22	744	5	markedly	markedly	RB
cord-023439-r04y1j22	744	6	suppressed	suppress	VBD
cord-023439-r04y1j22	744	7	NO	no	DT
cord-023439-r04y1j22	744	8	release	release	NN
cord-023439-r04y1j22	744	9	from	from	IN
cord-023439-r04y1j22	744	10	macrophages	macrophage	NNS
cord-023439-r04y1j22	744	11	alone	alone	RB
cord-023439-r04y1j22	744	12	,	,	,
cord-023439-r04y1j22	744	13	it	-PRON-	PRP
cord-023439-r04y1j22	744	14	significantly	significantly	RB
cord-023439-r04y1j22	744	15	potentiated	potentiate	VBD
cord-023439-r04y1j22	744	16	NO	no	DT
cord-023439-r04y1j22	744	17	production	production	NN
cord-023439-r04y1j22	744	18	in	in	IN
cord-023439-r04y1j22	744	19	cocultures	coculture	NNS
cord-023439-r04y1j22	744	20	of	of	IN
cord-023439-r04y1j22	744	21	macrophages	macrophage	NNS
cord-023439-r04y1j22	744	22	and	and	CC
cord-023439-r04y1j22	744	23	C6	c6	NN
cord-023439-r04y1j22	744	24	cells	cell	NNS
cord-023439-r04y1j22	744	25	,	,	,
cord-023439-r04y1j22	744	26	after	after	IN
cord-023439-r04y1j22	744	27	48	48	CD
cord-023439-r04y1j22	744	28	h	h	NN
cord-023439-r04y1j22	744	29	of	of	IN
cord-023439-r04y1j22	744	30	cultivation	cultivation	NN
cord-023439-r04y1j22	744	31	.	.	.
cord-023439-r04y1j22	745	1	Accordingly	accordingly	RB
cord-023439-r04y1j22	745	2	,	,	,
cord-023439-r04y1j22	745	3	the	the	DT
cord-023439-r04y1j22	745	4	viability	viability	NN
cord-023439-r04y1j22	745	5	of	of	IN
cord-023439-r04y1j22	745	6	C6	C6	NNP
cord-023439-r04y1j22	745	7	cells	cell	NNS
cord-023439-r04y1j22	745	8	cocultivated	cocultivate	VBN
cord-023439-r04y1j22	745	9	with	with	IN
cord-023439-r04y1j22	745	10	macrophages	macrophage	NNS
cord-023439-r04y1j22	745	11	was	be	VBD
cord-023439-r04y1j22	745	12	reduced	reduce	VBN
cord-023439-r04y1j22	745	13	in	in	IN
cord-023439-r04y1j22	745	14	the	the	DT
cord-023439-r04y1j22	745	15	presence	presence	NN
cord-023439-r04y1j22	745	16	of	of	IN
cord-023439-r04y1j22	745	17	AE	AE	NNP
cord-023439-r04y1j22	745	18	.	.	.
cord-023439-r04y1j22	746	1	Moreover	moreover	RB
cord-023439-r04y1j22	746	2	,	,	,
cord-023439-r04y1j22	746	3	the	the	DT
cord-023439-r04y1j22	746	4	observed	observed	JJ
cord-023439-r04y1j22	746	5	AE	AE	NNP
cord-023439-r04y1j22	746	6	-	-	HYPH
cord-023439-r04y1j22	746	7	imposed	impose	VBN
cord-023439-r04y1j22	746	8	potentiation	potentiation	NN
cord-023439-r04y1j22	746	9	of	of	IN
cord-023439-r04y1j22	746	10	NO	no	DT
cord-023439-r04y1j22	746	11	production	production	NN
cord-023439-r04y1j22	746	12	in	in	IN
cord-023439-r04y1j22	746	13	macrophages	macrophage	NNS
cord-023439-r04y1j22	746	14	was	be	VBD
cord-023439-r04y1j22	746	15	closely	closely	RB
cord-023439-r04y1j22	746	16	related	relate	VBN
cord-023439-r04y1j22	746	17	to	to	IN
cord-023439-r04y1j22	746	18	macrophage	macrophage	NN
cord-023439-r04y1j22	746	19	culture	culture	NN
cord-023439-r04y1j22	746	20	cell	cell	NN
cord-023439-r04y1j22	746	21	density	density	NN
cord-023439-r04y1j22	746	22	.	.	.
cord-023439-r04y1j22	747	1	According	accord	VBG
cord-023439-r04y1j22	747	2	to	to	IN
cord-023439-r04y1j22	747	3	these	these	DT
cord-023439-r04y1j22	747	4	data	datum	NNS
cord-023439-r04y1j22	747	5	,	,	,
cord-023439-r04y1j22	747	6	we	-PRON-	PRP
cord-023439-r04y1j22	747	7	proposed	propose	VBD
cord-023439-r04y1j22	747	8	that	that	IN
cord-023439-r04y1j22	747	9	NO	no	DT
cord-023439-r04y1j22	747	10	modulator	modulator	NN
cord-023439-r04y1j22	747	11	capacity	capacity	NN
cord-023439-r04y1j22	747	12	of	of	IN
cord-023439-r04y1j22	747	13	AE	AE	NNP
cord-023439-r04y1j22	747	14	strongly	strongly	RB
cord-023439-r04y1j22	747	15	depended	depend	VBD
cord-023439-r04y1j22	747	16	on	on	IN
cord-023439-r04y1j22	747	17	intercellular	intercellular	JJ
cord-023439-r04y1j22	747	18	contact	contact	NN
cord-023439-r04y1j22	747	19	,	,	,
cord-023439-r04y1j22	747	20	indicating	indicate	VBG
cord-023439-r04y1j22	747	21	that	that	IN
cord-023439-r04y1j22	747	22	macrophage	macrophage	NN
cord-023439-r04y1j22	747	23	antitumour	antitumour	JJ
cord-023439-r04y1j22	747	24	response	response	NN
cord-023439-r04y1j22	747	25	was	be	VBD
cord-023439-r04y1j22	747	26	not	not	RB
cord-023439-r04y1j22	747	27	compromised	compromised	JJ
cord-023439-r04y1j22	747	28	but	but	CC
cord-023439-r04y1j22	747	29	even	even	RB
cord-023439-r04y1j22	747	30	potentiated	potentiate	VBN
cord-023439-r04y1j22	747	31	by	by	IN
cord-023439-r04y1j22	747	32	AE	AE	NNP
cord-023439-r04y1j22	747	33	.	.	.
cord-023439-r04y1j22	748	1	Immunotherapy	immunotherapy	NN
cord-023439-r04y1j22	748	2	represents	represent	VBZ
cord-023439-r04y1j22	748	3	an	an	DT
cord-023439-r04y1j22	748	4	attractive	attractive	JJ
cord-023439-r04y1j22	748	5	fourth	fourth	JJ
cord-023439-r04y1j22	748	6	-	-	HYPH
cord-023439-r04y1j22	748	7	modality	modality	NN
cord-023439-r04y1j22	748	8	therapeutic	therapeutic	JJ
cord-023439-r04y1j22	748	9	approach	approach	NN
cord-023439-r04y1j22	748	10	,	,	,
cord-023439-r04y1j22	748	11	especially	especially	RB
cord-023439-r04y1j22	748	12	in	in	IN
cord-023439-r04y1j22	748	13	the	the	DT
cord-023439-r04y1j22	748	14	light	light	NN
cord-023439-r04y1j22	748	15	of	of	IN
cord-023439-r04y1j22	748	16	the	the	DT
cord-023439-r04y1j22	748	17	shortcomings	shortcoming	NNS
cord-023439-r04y1j22	748	18	of	of	IN
cord-023439-r04y1j22	748	19	conventional	conventional	JJ
cord-023439-r04y1j22	748	20	surgery	surgery	NN
cord-023439-r04y1j22	748	21	,	,	,
cord-023439-r04y1j22	748	22	radiation	radiation	NN
cord-023439-r04y1j22	748	23	and	and	CC
cord-023439-r04y1j22	748	24	chemotherapies	chemotherapy	NNS
cord-023439-r04y1j22	748	25	in	in	IN
cord-023439-r04y1j22	748	26	the	the	DT
cord-023439-r04y1j22	748	27	management	management	NN
cord-023439-r04y1j22	748	28	of	of	IN
cord-023439-r04y1j22	748	29	metastatic	metastatic	JJ
cord-023439-r04y1j22	748	30	cancer	cancer	NN
cord-023439-r04y1j22	748	31	.	.	.
cord-023439-r04y1j22	749	1	To	to	IN
cord-023439-r04y1j22	749	2	this	this	DT
cord-023439-r04y1j22	749	3	end	end	NN
cord-023439-r04y1j22	749	4	,	,	,
cord-023439-r04y1j22	749	5	a	a	DT
cord-023439-r04y1j22	749	6	large	large	JJ
cord-023439-r04y1j22	749	7	number	number	NN
cord-023439-r04y1j22	749	8	of	of	IN
cord-023439-r04y1j22	749	9	peptide	peptide	JJ
cord-023439-r04y1j22	749	10	antigens	antigen	NNS
cord-023439-r04y1j22	749	11	derived	derive	VBN
cord-023439-r04y1j22	749	12	from	from	IN
cord-023439-r04y1j22	749	13	TAA	TAA	NNP
cord-023439-r04y1j22	749	14	have	have	VBP
cord-023439-r04y1j22	749	15	been	be	VBN
cord-023439-r04y1j22	749	16	applied	apply	VBN
cord-023439-r04y1j22	749	17	in	in	IN
cord-023439-r04y1j22	749	18	immunotherapeutic	immunotherapeutic	JJ
cord-023439-r04y1j22	749	19	trials	trial	NNS
cord-023439-r04y1j22	749	20	for	for	IN
cord-023439-r04y1j22	749	21	the	the	DT
cord-023439-r04y1j22	749	22	treatment	treatment	NN
cord-023439-r04y1j22	749	23	of	of	IN
cord-023439-r04y1j22	749	24	various	various	JJ
cord-023439-r04y1j22	749	25	malignancies	malignancy	NNS
cord-023439-r04y1j22	749	26	,	,	,
cord-023439-r04y1j22	749	27	e.g.	e.g.	IN
cord-023439-r04y1j22	749	28	cancers	cancer	NNS
cord-023439-r04y1j22	749	29	of	of	IN
cord-023439-r04y1j22	749	30	the	the	DT
cord-023439-r04y1j22	749	31	breast	breast	NN
cord-023439-r04y1j22	749	32	,	,	,
cord-023439-r04y1j22	749	33	prostate	prostate	NN
cord-023439-r04y1j22	749	34	and	and	CC
cord-023439-r04y1j22	749	35	kidney	kidney	NN
cord-023439-r04y1j22	749	36	,	,	,
cord-023439-r04y1j22	749	37	in	in	IN
cord-023439-r04y1j22	749	38	addition	addition	NN
cord-023439-r04y1j22	749	39	to	to	IN
cord-023439-r04y1j22	749	40	haematological	haematological	JJ
cord-023439-r04y1j22	749	41	cancers	cancer	NNS
cord-023439-r04y1j22	749	42	.	.	.
cord-023439-r04y1j22	750	1	In	in	IN
cord-023439-r04y1j22	750	2	some	some	DT
cord-023439-r04y1j22	750	3	cases	case	NNS
cord-023439-r04y1j22	750	4	the	the	DT
cord-023439-r04y1j22	750	5	response	response	NN
cord-023439-r04y1j22	750	6	rates	rate	NNS
cord-023439-r04y1j22	750	7	have	have	VBP
cord-023439-r04y1j22	750	8	been	be	VBN
cord-023439-r04y1j22	750	9	impressive	impressive	JJ
cord-023439-r04y1j22	750	10	and	and	CC
cord-023439-r04y1j22	750	11	no	no	DT
cord-023439-r04y1j22	750	12	adverse	adverse	JJ
cord-023439-r04y1j22	750	13	autoimmunity	autoimmunity	NN
cord-023439-r04y1j22	750	14	have	have	VBP
cord-023439-r04y1j22	750	15	been	be	VBN
cord-023439-r04y1j22	750	16	observed	observe	VBN
cord-023439-r04y1j22	750	17	.	.	.
cord-023439-r04y1j22	751	1	A	a	DT
cord-023439-r04y1j22	751	2	major	major	JJ
cord-023439-r04y1j22	751	3	strategic	strategic	JJ
cord-023439-r04y1j22	751	4	difficulty	difficulty	NN
cord-023439-r04y1j22	751	5	associated	associate	VBN
cord-023439-r04y1j22	751	6	with	with	IN
cord-023439-r04y1j22	751	7	these	these	DT
cord-023439-r04y1j22	751	8	trials	trial	NNS
cord-023439-r04y1j22	751	9	relates	relate	VBZ
cord-023439-r04y1j22	751	10	to	to	IN
cord-023439-r04y1j22	751	11	the	the	DT
cord-023439-r04y1j22	751	12	choice	choice	NN
cord-023439-r04y1j22	751	13	of	of	IN
cord-023439-r04y1j22	751	14	best	best	RB
cord-023439-r04y1j22	751	15	-	-	HYPH
cord-023439-r04y1j22	751	16	suited	suit	VBN
cord-023439-r04y1j22	751	17	peptide	peptide	NN
cord-023439-r04y1j22	751	18	antigens	antigen	NNS
cord-023439-r04y1j22	751	19	.	.	.
cord-023439-r04y1j22	752	1	The	the	DT
cord-023439-r04y1j22	752	2	vast	vast	JJ
cord-023439-r04y1j22	752	3	majority	majority	NN
cord-023439-r04y1j22	752	4	of	of	IN
cord-023439-r04y1j22	752	5	the	the	DT
cord-023439-r04y1j22	752	6	antigens	antigen	NNS
cord-023439-r04y1j22	752	7	described	describe	VBN
cord-023439-r04y1j22	752	8	thus	thus	RB
cord-023439-r04y1j22	752	9	far	far	RB
cord-023439-r04y1j22	752	10	is	be	VBZ
cord-023439-r04y1j22	752	11	not	not	RB
cord-023439-r04y1j22	752	12	vital	vital	JJ
cord-023439-r04y1j22	752	13	for	for	IN
cord-023439-r04y1j22	752	14	survival	survival	NN
cord-023439-r04y1j22	752	15	and	and	CC
cord-023439-r04y1j22	752	16	growth	growth	NN
cord-023439-r04y1j22	752	17	of	of	IN
cord-023439-r04y1j22	752	18	the	the	DT
cord-023439-r04y1j22	752	19	tumour	tumour	NN
cord-023439-r04y1j22	752	20	cells	cell	NNS
cord-023439-r04y1j22	752	21	,	,	,
cord-023439-r04y1j22	752	22	and	and	CC
cord-023439-r04y1j22	752	23	immunoselection	immunoselection	NN
cord-023439-r04y1j22	752	24	of	of	IN
cord-023439-r04y1j22	752	25	antigen	antigen	NN
cord-023439-r04y1j22	752	26	-	-	HYPH
cord-023439-r04y1j22	752	27	loss	loss	NN
cord-023439-r04y1j22	752	28	variants	variant	NNS
cord-023439-r04y1j22	752	29	may	may	MD
cord-023439-r04y1j22	752	30	therefore	therefore	RB
cord-023439-r04y1j22	752	31	prove	prove	VB
cord-023439-r04y1j22	752	32	to	to	TO
cord-023439-r04y1j22	752	33	be	be	VB
cord-023439-r04y1j22	752	34	an	an	DT
cord-023439-r04y1j22	752	35	additional	additional	JJ
cord-023439-r04y1j22	752	36	obstacle	obstacle	NN
cord-023439-r04y1j22	752	37	for	for	IN
cord-023439-r04y1j22	752	38	the	the	DT
cord-023439-r04y1j22	752	39	clinical	clinical	JJ
cord-023439-r04y1j22	752	40	applicability	applicability	NN
cord-023439-r04y1j22	752	41	of	of	IN
cord-023439-r04y1j22	752	42	most	most	JJS
cord-023439-r04y1j22	752	43	of	of	IN
cord-023439-r04y1j22	752	44	the	the	DT
cord-023439-r04y1j22	752	45	known	know	VBN
cord-023439-r04y1j22	752	46	peptide	peptide	NN
cord-023439-r04y1j22	752	47	epitopes	epitope	NNS
cord-023439-r04y1j22	752	48	.	.	.
cord-023439-r04y1j22	753	1	In	in	IN
cord-023439-r04y1j22	753	2	this	this	DT
cord-023439-r04y1j22	753	3	respect	respect	NN
cord-023439-r04y1j22	753	4	,	,	,
cord-023439-r04y1j22	753	5	the	the	DT
cord-023439-r04y1j22	753	6	development	development	NN
cord-023439-r04y1j22	753	7	of	of	IN
cord-023439-r04y1j22	753	8	acquired	acquire	VBN
cord-023439-r04y1j22	753	9	antigen	antigen	NN
cord-023439-r04y1j22	753	10	loss	loss	NN
cord-023439-r04y1j22	753	11	during	during	IN
cord-023439-r04y1j22	753	12	immunotherapy	immunotherapy	NN
cord-023439-r04y1j22	753	13	has	have	VBZ
cord-023439-r04y1j22	753	14	been	be	VBN
cord-023439-r04y1j22	753	15	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	753	16	in	in	IN
cord-023439-r04y1j22	753	17	several	several	JJ
cord-023439-r04y1j22	753	18	cases	case	NNS
cord-023439-r04y1j22	753	19	.	.	.
cord-023439-r04y1j22	754	1	Obviously	obviously	RB
cord-023439-r04y1j22	754	2	,	,	,
cord-023439-r04y1j22	754	3	the	the	DT
cord-023439-r04y1j22	754	4	development	development	NN
cord-023439-r04y1j22	754	5	of	of	IN
cord-023439-r04y1j22	754	6	loss	loss	NN
cord-023439-r04y1j22	754	7	-	-	HYPH
cord-023439-r04y1j22	754	8	variant	variant	NN
cord-023439-r04y1j22	754	9	tumour	tumour	NN
cord-023439-r04y1j22	754	10	cells	cell	NNS
cord-023439-r04y1j22	754	11	implies	imply	VBZ
cord-023439-r04y1j22	754	12	that	that	IN
cord-023439-r04y1j22	754	13	these	these	DT
cord-023439-r04y1j22	754	14	cells	cell	NNS
cord-023439-r04y1j22	754	15	acquire	acquire	VBP
cord-023439-r04y1j22	754	16	a	a	DT
cord-023439-r04y1j22	754	17	pronounced	pronounce	VBN
cord-023439-r04y1j22	754	18	growth	growth	NN
cord-023439-r04y1j22	754	19	advantage	advantage	NN
cord-023439-r04y1j22	754	20	and	and	CC
cord-023439-r04y1j22	754	21	are	be	VBP
cord-023439-r04y1j22	754	22	left	leave	VBN
cord-023439-r04y1j22	754	23	unaffected	unaffected	JJ
cord-023439-r04y1j22	754	24	by	by	IN
cord-023439-r04y1j22	754	25	further	further	JJ
cord-023439-r04y1j22	754	26	treatment	treatment	NN
cord-023439-r04y1j22	754	27	.	.	.
cord-023439-r04y1j22	755	1	Ideally	ideally	RB
cord-023439-r04y1j22	755	2	,	,	,
cord-023439-r04y1j22	755	3	target	target	NN
cord-023439-r04y1j22	755	4	antigens	antigen	NNS
cord-023439-r04y1j22	755	5	should	should	MD
cord-023439-r04y1j22	755	6	be	be	VB
cord-023439-r04y1j22	755	7	derived	derive	VBN
cord-023439-r04y1j22	755	8	from	from	IN
cord-023439-r04y1j22	755	9	proteins	protein	NNS
cord-023439-r04y1j22	755	10	required	require	VBN
cord-023439-r04y1j22	755	11	for	for	IN
cord-023439-r04y1j22	755	12	survival	survival	NN
cord-023439-r04y1j22	755	13	and	and	CC
cord-023439-r04y1j22	755	14	growth	growth	NN
cord-023439-r04y1j22	755	15	of	of	IN
cord-023439-r04y1j22	755	16	tumour	tumour	NN
cord-023439-r04y1j22	755	17	cells	cell	NNS
cord-023439-r04y1j22	755	18	,	,	,
cord-023439-r04y1j22	755	19	as	as	IN
cord-023439-r04y1j22	755	20	antigens	antigen	NNS
cord-023439-r04y1j22	755	21	with	with	IN
cord-023439-r04y1j22	755	22	these	these	DT
cord-023439-r04y1j22	755	23	characteristics	characteristic	NNS
cord-023439-r04y1j22	755	24	would	would	MD
cord-023439-r04y1j22	755	25	not	not	RB
cord-023439-r04y1j22	755	26	be	be	VB
cord-023439-r04y1j22	755	27	inflicted	inflict	VBN
cord-023439-r04y1j22	755	28	by	by	IN
cord-023439-r04y1j22	755	29	the	the	DT
cord-023439-r04y1j22	755	30	development	development	NN
cord-023439-r04y1j22	755	31	of	of	IN
cord-023439-r04y1j22	755	32	loss	loss	NN
cord-023439-r04y1j22	755	33	-	-	HYPH
cord-023439-r04y1j22	755	34	variant	variant	NN
cord-023439-r04y1j22	755	35	tumour	tumour	NN
cord-023439-r04y1j22	755	36	cells	cell	NNS
cord-023439-r04y1j22	755	37	.	.	.
cord-023439-r04y1j22	756	1	In	in	IN
cord-023439-r04y1j22	756	2	this	this	DT
cord-023439-r04y1j22	756	3	respect	respect	NN
cord-023439-r04y1j22	756	4	,	,	,
cord-023439-r04y1j22	756	5	several	several	JJ
cord-023439-r04y1j22	756	6	inhibitors	inhibitor	NNS
cord-023439-r04y1j22	756	7	of	of	IN
cord-023439-r04y1j22	756	8	apoptosis	apoptosis	NN
cord-023439-r04y1j22	756	9	proteins	protein	NNS
cord-023439-r04y1j22	756	10	(	(	-LRB-
cord-023439-r04y1j22	756	11	IAPs	IAPs	NNP
cord-023439-r04y1j22	756	12	)	)	-RRB-
cord-023439-r04y1j22	756	13	are	be	VBP
cord-023439-r04y1j22	756	14	universally	universally	RB
cord-023439-r04y1j22	756	15	expressed	express	VBN
cord-023439-r04y1j22	756	16	among	among	IN
cord-023439-r04y1j22	756	17	tumours	tumour	NNS
cord-023439-r04y1j22	756	18	and	and	CC
cord-023439-r04y1j22	756	19	play	play	VB
cord-023439-r04y1j22	756	20	an	an	DT
cord-023439-r04y1j22	756	21	important	important	JJ
cord-023439-r04y1j22	756	22	role	role	NN
cord-023439-r04y1j22	756	23	in	in	IN
cord-023439-r04y1j22	756	24	tumour	tumour	NN
cord-023439-r04y1j22	756	25	cell	cell	NN
cord-023439-r04y1j22	756	26	escape	escape	NN
cord-023439-r04y1j22	756	27	from	from	IN
cord-023439-r04y1j22	756	28	apoptosis	apoptosis	NN
cord-023439-r04y1j22	756	29	.	.	.
cord-023439-r04y1j22	757	1	We	-PRON-	PRP
cord-023439-r04y1j22	757	2	have	have	VBP
cord-023439-r04y1j22	757	3	characterized	characterize	VBN
cord-023439-r04y1j22	757	4	spontaneous	spontaneous	JJ
cord-023439-r04y1j22	757	5	T	t	NN
cord-023439-r04y1j22	757	6	-	-	HYPH
cord-023439-r04y1j22	757	7	cell	cell	NN
cord-023439-r04y1j22	757	8	reactivity	reactivity	NN
cord-023439-r04y1j22	757	9	against	against	IN
cord-023439-r04y1j22	757	10	IAPderived	iapderived	JJ
cord-023439-r04y1j22	757	11	peptides	peptide	NNS
cord-023439-r04y1j22	757	12	in	in	IN
cord-023439-r04y1j22	757	13	cancer	cancer	NN
cord-023439-r04y1j22	757	14	patients	patient	NNS
cord-023439-r04y1j22	757	15	.	.	.
cord-023439-r04y1j22	758	1	From	from	IN
cord-023439-r04y1j22	758	2	the	the	DT
cord-023439-r04y1j22	758	3	IAP	IAP	NNP
cord-023439-r04y1j22	758	4	survivin	survivin	NN
cord-023439-r04y1j22	758	5	,	,	,
cord-023439-r04y1j22	758	6	we	-PRON-	PRP
cord-023439-r04y1j22	758	7	have	have	VBP
cord-023439-r04y1j22	758	8	characterized	characterize	VBN
cord-023439-r04y1j22	758	9	peptides	peptide	NNS
cord-023439-r04y1j22	758	10	restricted	restrict	VBN
cord-023439-r04y1j22	758	11	to	to	IN
cord-023439-r04y1j22	758	12	the	the	DT
cord-023439-r04y1j22	758	13	Class	class	NN
cord-023439-r04y1j22	759	1	I	-PRON-	PRP
cord-023439-r04y1j22	759	2	molecules	molecule	VBZ
cord-023439-r04y1j22	759	3	HLA	HLA	NNP
cord-023439-r04y1j22	759	4	-	-	HYPH
cord-023439-r04y1j22	759	5	A1	A1	NNP
cord-023439-r04y1j22	759	6	,	,	,
cord-023439-r04y1j22	759	7	A2	A2	NNP
cord-023439-r04y1j22	759	8	,	,	,
cord-023439-r04y1j22	759	9	A3	A3	NNP
cord-023439-r04y1j22	759	10	,	,	,
cord-023439-r04y1j22	759	11	A11	A11	NNP
cord-023439-r04y1j22	759	12	,	,	,
cord-023439-r04y1j22	759	13	B7	b7	NN
cord-023439-r04y1j22	759	14	and	and	CC
cord-023439-r04y1j22	759	15	B35	B35	NNP
cord-023439-r04y1j22	759	16	.	.	.
cord-023439-r04y1j22	760	1	Furthermore	furthermore	RB
cord-023439-r04y1j22	760	2	,	,	,
cord-023439-r04y1j22	760	3	we	-PRON-	PRP
cord-023439-r04y1j22	760	4	have	have	VBP
cord-023439-r04y1j22	760	5	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	760	6	that	that	IN
cord-023439-r04y1j22	760	7	survivin	survivin	NN
cord-023439-r04y1j22	760	8	-	-	HYPH
cord-023439-r04y1j22	760	9	specific	specific	JJ
cord-023439-r04y1j22	760	10	T	t	NN
cord-023439-r04y1j22	760	11	cells	cell	NNS
cord-023439-r04y1j22	760	12	infiltrate	infiltrate	VBP
cord-023439-r04y1j22	760	13	metastatic	metastatic	JJ
cord-023439-r04y1j22	760	14	lesions	lesion	NNS
cord-023439-r04y1j22	760	15	and	and	CC
cord-023439-r04y1j22	760	16	that	that	IN
cord-023439-r04y1j22	760	17	isolated	isolate	VBN
cord-023439-r04y1j22	760	18	survivinspecific	survivinspecific	NN
cord-023439-r04y1j22	760	19	CTLs	ctl	NNS
cord-023439-r04y1j22	760	20	are	be	VBP
cord-023439-r04y1j22	760	21	capable	capable	JJ
cord-023439-r04y1j22	760	22	of	of	IN
cord-023439-r04y1j22	760	23	killing	kill	VBG
cord-023439-r04y1j22	760	24	HLA	HLA	NNP
cord-023439-r04y1j22	760	25	-	-	HYPH
cord-023439-r04y1j22	760	26	matched	match	VBN
cord-023439-r04y1j22	760	27	tumour	tumour	NN
cord-023439-r04y1j22	760	28	cells	cell	NNS
cord-023439-r04y1j22	760	29	.	.	.
cord-023439-r04y1j22	761	1	Survivin	Survivin	NNP
cord-023439-r04y1j22	761	2	-	-	HYPH
cord-023439-r04y1j22	761	3	derived	derive	VBN
cord-023439-r04y1j22	761	4	peptides	peptide	NNS
cord-023439-r04y1j22	761	5	are	be	VBP
cord-023439-r04y1j22	761	6	now	now	RB
cord-023439-r04y1j22	761	7	in	in	IN
cord-023439-r04y1j22	761	8	clinical	clinical	JJ
cord-023439-r04y1j22	761	9	trial	trial	NN
cord-023439-r04y1j22	761	10	,	,	,
cord-023439-r04y1j22	761	11	and	and	CC
cord-023439-r04y1j22	761	12	continued	continue	VBD
cord-023439-r04y1j22	761	13	work	work	NN
cord-023439-r04y1j22	761	14	in	in	IN
cord-023439-r04y1j22	761	15	our	-PRON-	PRP$
cord-023439-r04y1j22	761	16	lab	lab	NN
cord-023439-r04y1j22	761	17	has	have	VBZ
cord-023439-r04y1j22	761	18	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	761	19	that	that	IN
cord-023439-r04y1j22	761	20	other	other	JJ
cord-023439-r04y1j22	761	21	IAPs	iap	NNS
cord-023439-r04y1j22	761	22	are	be	VBP
cord-023439-r04y1j22	761	23	targets	target	NNS
cord-023439-r04y1j22	761	24	for	for	IN
cord-023439-r04y1j22	761	25	spontaneous	spontaneous	JJ
cord-023439-r04y1j22	761	26	T	t	NN
cord-023439-r04y1j22	761	27	-	-	HYPH
cord-023439-r04y1j22	761	28	cell	cell	NN
cord-023439-r04y1j22	761	29	reactivity	reactivity	NN
cord-023439-r04y1j22	761	30	in	in	IN
cord-023439-r04y1j22	761	31	cancer	cancer	NN
cord-023439-r04y1j22	761	32	patients	patient	NNS
cord-023439-r04y1j22	761	33	.	.	.
cord-023439-r04y1j22	762	1	We	-PRON-	PRP
cord-023439-r04y1j22	762	2	previously	previously	RB
cord-023439-r04y1j22	762	3	reported	report	VBD
cord-023439-r04y1j22	762	4	that	that	IN
cord-023439-r04y1j22	762	5	in	in	IN
cord-023439-r04y1j22	762	6	mice	mouse	NNS
cord-023439-r04y1j22	762	7	with	with	IN
cord-023439-r04y1j22	762	8	large	large	JJ
cord-023439-r04y1j22	762	9	progressing	progress	VBG
cord-023439-r04y1j22	762	10	T	t	NN
cord-023439-r04y1j22	762	11	-	-	HYPH
cord-023439-r04y1j22	762	12	cell	cell	NN
cord-023439-r04y1j22	762	13	lymphoma	lymphoma	NN
cord-023439-r04y1j22	762	14	tumours	tumour	NNS
cord-023439-r04y1j22	762	15	,	,	,
cord-023439-r04y1j22	762	16	dysfunctions	dysfunction	NNS
cord-023439-r04y1j22	762	17	in	in	IN
cord-023439-r04y1j22	762	18	the	the	DT
cord-023439-r04y1j22	762	19	antitumour	antitumour	JJ
cord-023439-r04y1j22	762	20	CTL	CTL	NNP
cord-023439-r04y1j22	762	21	activity	activity	NN
cord-023439-r04y1j22	762	22	occur	occur	VBP
cord-023439-r04y1j22	762	23	,	,	,
cord-023439-r04y1j22	762	24	associated	associate	VBN
cord-023439-r04y1j22	762	25	with	with	IN
cord-023439-r04y1j22	762	26	an	an	DT
cord-023439-r04y1j22	762	27	accumulation	accumulation	NN
cord-023439-r04y1j22	762	28	of	of	IN
cord-023439-r04y1j22	762	29	splenic	splenic	JJ
cord-023439-r04y1j22	762	30	arginase	arginase	NN
cord-023439-r04y1j22	762	31	-	-	HYPH
cord-023439-r04y1j22	762	32	producing	produce	VBG
cord-023439-r04y1j22	762	33	myeloid	myeloid	NN
cord-023439-r04y1j22	762	34	suppressor	suppressor	NN
cord-023439-r04y1j22	762	35	cells	cell	NNS
cord-023439-r04y1j22	762	36	(	(	-LRB-
cord-023439-r04y1j22	762	37	MSCs	msc	NNS
cord-023439-r04y1j22	762	38	)	)	-RRB-
cord-023439-r04y1j22	762	39	.	.	.
cord-023439-r04y1j22	763	1	In	in	IN
cord-023439-r04y1j22	763	2	this	this	DT
cord-023439-r04y1j22	763	3	study	study	NN
cord-023439-r04y1j22	763	4	,	,	,
cord-023439-r04y1j22	763	5	we	-PRON-	PRP
cord-023439-r04y1j22	763	6	first	first	RB
cord-023439-r04y1j22	763	7	demonstrate	demonstrate	VBP
cord-023439-r04y1j22	763	8	that	that	IN
cord-023439-r04y1j22	763	9	both	both	CC
cord-023439-r04y1j22	763	10	the	the	DT
cord-023439-r04y1j22	763	11	presence	presence	NN
cord-023439-r04y1j22	763	12	and	and	CC
cord-023439-r04y1j22	763	13	the	the	DT
cord-023439-r04y1j22	763	14	activation	activation	NN
cord-023439-r04y1j22	763	15	state	state	NN
cord-023439-r04y1j22	763	16	of	of	IN
cord-023439-r04y1j22	763	17	these	these	DT
cord-023439-r04y1j22	763	18	MSC	MSC	NNP
cord-023439-r04y1j22	763	19	depends	depend	VBZ
cord-023439-r04y1j22	763	20	on	on	IN
cord-023439-r04y1j22	763	21	tumour	tumour	NN
cord-023439-r04y1j22	763	22	evolution	evolution	NN
cord-023439-r04y1j22	763	23	.	.	.
cord-023439-r04y1j22	764	1	While	while	IN
cord-023439-r04y1j22	764	2	in	in	IN
cord-023439-r04y1j22	764	3	tumour	tumour	NN
cord-023439-r04y1j22	764	4	regressors	regressor	NNS
cord-023439-r04y1j22	764	5	hardly	hardly	RB
cord-023439-r04y1j22	764	6	any	any	DT
cord-023439-r04y1j22	764	7	arginase	arginase	NN
cord-023439-r04y1j22	764	8	-	-	HYPH
cord-023439-r04y1j22	764	9	producing	produce	VBG
cord-023439-r04y1j22	764	10	MSC	MSC	NNP
cord-023439-r04y1j22	764	11	can	can	MD
cord-023439-r04y1j22	764	12	be	be	VB
cord-023439-r04y1j22	764	13	found	find	VBN
cord-023439-r04y1j22	764	14	,	,	,
cord-023439-r04y1j22	764	15	both	both	CC
cord-023439-r04y1j22	764	16	the	the	DT
cord-023439-r04y1j22	764	17	amount	amount	NN
cord-023439-r04y1j22	764	18	and	and	CC
cord-023439-r04y1j22	764	19	the	the	DT
cord-023439-r04y1j22	764	20	arginase	arginase	NN
cord-023439-r04y1j22	764	21	activity	activity	NN
cord-023439-r04y1j22	764	22	of	of	IN
cord-023439-r04y1j22	764	23	this	this	DT
cord-023439-r04y1j22	764	24	population	population	NN
cord-023439-r04y1j22	764	25	expands	expand	VBZ
cord-023439-r04y1j22	764	26	from	from	IN
cord-023439-r04y1j22	764	27	early	early	RB
cord-023439-r04y1j22	764	28	over	over	IN
cord-023439-r04y1j22	764	29	late	late	JJ
cord-023439-r04y1j22	764	30	progressors	progressor	NNS
cord-023439-r04y1j22	764	31	.	.	.
cord-023439-r04y1j22	765	1	This	this	DT
cord-023439-r04y1j22	765	2	gradual	gradual	JJ
cord-023439-r04y1j22	765	3	induction	induction	NN
cord-023439-r04y1j22	765	4	of	of	IN
cord-023439-r04y1j22	765	5	MSCs	mscs	NN
cord-023439-r04y1j22	765	6	is	be	VBZ
cord-023439-r04y1j22	765	7	paralleled	parallel	VBN
cord-023439-r04y1j22	765	8	by	by	IN
cord-023439-r04y1j22	765	9	an	an	DT
cord-023439-r04y1j22	765	10	increasing	increase	VBG
cord-023439-r04y1j22	765	11	suppression	suppression	NN
cord-023439-r04y1j22	765	12	of	of	IN
cord-023439-r04y1j22	765	13	CTL	CTL	NNP
cord-023439-r04y1j22	765	14	activity	activity	NN
cord-023439-r04y1j22	765	15	and	and	CC
cord-023439-r04y1j22	765	16	Th1	th1	NN
cord-023439-r04y1j22	765	17	,	,	,
cord-023439-r04y1j22	765	18	but	but	CC
cord-023439-r04y1j22	765	19	not	not	RB
cord-023439-r04y1j22	765	20	Th2	th2	CD
cord-023439-r04y1j22	765	21	,	,	,
cord-023439-r04y1j22	765	22	cytokine	cytokine	JJ
cord-023439-r04y1j22	765	23	production	production	NN
cord-023439-r04y1j22	765	24	.	.	.
cord-023439-r04y1j22	766	1	Upon	upon	IN
cord-023439-r04y1j22	766	2	analysing	analyse	VBG
cord-023439-r04y1j22	766	3	the	the	DT
cord-023439-r04y1j22	766	4	molecular	molecular	JJ
cord-023439-r04y1j22	766	5	repertoire	repertoire	NN
cord-023439-r04y1j22	766	6	of	of	IN
cord-023439-r04y1j22	766	7	MSC	MSC	NNP
cord-023439-r04y1j22	766	8	in	in	IN
cord-023439-r04y1j22	766	9	vitro	vitro	FW
cord-023439-r04y1j22	766	10	,	,	,
cord-023439-r04y1j22	766	11	we	-PRON-	PRP
cord-023439-r04y1j22	766	12	found	find	VBD
cord-023439-r04y1j22	766	13	,	,	,
cord-023439-r04y1j22	766	14	besides	besides	IN
cord-023439-r04y1j22	766	15	arginase1	arginase1	NN
cord-023439-r04y1j22	766	16	,	,	,
cord-023439-r04y1j22	766	17	a	a	DT
cord-023439-r04y1j22	766	18	well	well	RB
cord-023439-r04y1j22	766	19	-	-	HYPH
cord-023439-r04y1j22	766	20	established	establish	VBN
cord-023439-r04y1j22	766	21	marker	marker	NN
cord-023439-r04y1j22	766	22	for	for	IN
cord-023439-r04y1j22	766	23	alternatively	alternatively	RB
cord-023439-r04y1j22	766	24	activated	activate	VBN
cord-023439-r04y1j22	766	25	myeloid	myeloid	NN
cord-023439-r04y1j22	766	26	cells	cell	NNS
cord-023439-r04y1j22	766	27	or	or	CC
cord-023439-r04y1j22	766	28	M2	M2	NNP
cord-023439-r04y1j22	766	29	,	,	,
cord-023439-r04y1j22	766	30	a	a	DT
cord-023439-r04y1j22	766	31	strong	strong	JJ
cord-023439-r04y1j22	766	32	upregulation	upregulation	NN
cord-023439-r04y1j22	766	33	of	of	IN
cord-023439-r04y1j22	766	34	FIZZ1	FIZZ1	NNP
cord-023439-r04y1j22	766	35	and	and	CC
cord-023439-r04y1j22	766	36	Ym	Ym	NNP
cord-023439-r04y1j22	766	37	,	,	,
cord-023439-r04y1j22	766	38	two	two	CD
cord-023439-r04y1j22	766	39	additional	additional	JJ
cord-023439-r04y1j22	766	40	recently	recently	RB
cord-023439-r04y1j22	766	41	identified	identify	VBN
cord-023439-r04y1j22	766	42	markers	marker	NNS
cord-023439-r04y1j22	766	43	for	for	IN
cord-023439-r04y1j22	766	44	M2	M2	NNP
cord-023439-r04y1j22	766	45	.	.	.
cord-023439-r04y1j22	767	1	Further	further	JJ
cord-023439-r04y1j22	767	2	evaluation	evaluation	NN
cord-023439-r04y1j22	767	3	of	of	IN
cord-023439-r04y1j22	767	4	molecular	molecular	JJ
cord-023439-r04y1j22	767	5	markers	marker	NNS
cord-023439-r04y1j22	767	6	by	by	IN
cord-023439-r04y1j22	767	7	microarray	microarray	NN
cord-023439-r04y1j22	767	8	analysis	analysis	NN
cord-023439-r04y1j22	767	9	in	in	IN
cord-023439-r04y1j22	767	10	MSC	MSC	NNP
cord-023439-r04y1j22	767	11	yielded	yield	VBD
cord-023439-r04y1j22	767	12	genes	gene	NNS
cord-023439-r04y1j22	767	13	involved	involve	VBN
cord-023439-r04y1j22	767	14	in	in	IN
cord-023439-r04y1j22	767	15	wound	wound	JJ
cord-023439-r04y1j22	767	16	healing	healing	NN
cord-023439-r04y1j22	767	17	(	(	-LRB-
cord-023439-r04y1j22	767	18	e.g.	e.g.	JJ
cord-023439-r04y1j22	767	19	coagulation	coagulation	NN
cord-023439-r04y1j22	767	20	factor	factor	NN
cord-023439-r04y1j22	767	21	XIIIa	XIIIa	NNPS
cord-023439-r04y1j22	767	22	)	)	-RRB-
cord-023439-r04y1j22	767	23	,	,	,
cord-023439-r04y1j22	767	24	anti	anti	JJ
cord-023439-r04y1j22	767	25	-	-	JJ
cord-023439-r04y1j22	767	26	inflammation	inflammation	NN
cord-023439-r04y1j22	767	27	(	(	-LRB-
cord-023439-r04y1j22	767	28	e.g.	e.g.	RB
cord-023439-r04y1j22	767	29	selenoprotein	selenoprotein	NNP
cord-023439-r04y1j22	767	30	P	P	NNP
cord-023439-r04y1j22	767	31	)	)	-RRB-
cord-023439-r04y1j22	767	32	,	,	,
cord-023439-r04y1j22	767	33	immunomodulation	immunomodulation	NNP
cord-023439-r04y1j22	767	34	(	(	-LRB-
cord-023439-r04y1j22	767	35	e.g.	e.g.	RB
cord-023439-r04y1j22	767	36	PD	PD	NNP
cord-023439-r04y1j22	767	37	-	-	HYPH
cord-023439-r04y1j22	767	38	L2	L2	NNP
cord-023439-r04y1j22	767	39	)	)	-RRB-
cord-023439-r04y1j22	767	40	and	and	CC
cord-023439-r04y1j22	767	41	fat	fat	NN
cord-023439-r04y1j22	767	42	and	and	CC
cord-023439-r04y1j22	767	43	sugar	sugar	NN
cord-023439-r04y1j22	767	44	metabolism	metabolism	NN
cord-023439-r04y1j22	767	45	(	(	-LRB-
cord-023439-r04y1j22	767	46	e.g.	e.g.	IN
cord-023439-r04y1j22	767	47	leptin	leptin	NN
cord-023439-r04y1j22	767	48	receptor	receptor	NN
cord-023439-r04y1j22	767	49	)	)	-RRB-
cord-023439-r04y1j22	767	50	.	.	.
cord-023439-r04y1j22	768	1	Of	of	IN
cord-023439-r04y1j22	768	2	note	note	NN
cord-023439-r04y1j22	768	3	,	,	,
cord-023439-r04y1j22	768	4	many	many	JJ
cord-023439-r04y1j22	768	5	of	of	IN
cord-023439-r04y1j22	768	6	these	these	DT
cord-023439-r04y1j22	768	7	genes	gene	NNS
cord-023439-r04y1j22	768	8	are	be	VBP
cord-023439-r04y1j22	768	9	regulated	regulate	VBN
cord-023439-r04y1j22	768	10	by	by	IN
cord-023439-r04y1j22	768	11	type	type	NN
cord-023439-r04y1j22	768	12	2	2	CD
cord-023439-r04y1j22	768	13	cytokines	cytokine	NNS
cord-023439-r04y1j22	768	14	(	(	-LRB-
cord-023439-r04y1j22	768	15	IL-4	IL-4	NNP
cord-023439-r04y1j22	768	16	,	,	,
cord-023439-r04y1j22	768	17	IL-13	IL-13	NNP
cord-023439-r04y1j22	768	18	and	and	CC
cord-023439-r04y1j22	768	19	IL-10	IL-10	NNP
cord-023439-r04y1j22	768	20	)	)	-RRB-
cord-023439-r04y1j22	768	21	and	and	CC
cord-023439-r04y1j22	768	22	are	be	VBP
cord-023439-r04y1j22	768	23	therefore	therefore	RB
cord-023439-r04y1j22	768	24	rather	rather	RB
cord-023439-r04y1j22	768	25	M2	M2	NNP
cord-023439-r04y1j22	768	26	associated	associate	VBN
cord-023439-r04y1j22	768	27	.	.	.
cord-023439-r04y1j22	769	1	Overall	overall	RB
cord-023439-r04y1j22	769	2	,	,	,
cord-023439-r04y1j22	769	3	our	-PRON-	PRP$
cord-023439-r04y1j22	769	4	data	datum	NNS
cord-023439-r04y1j22	769	5	provide	provide	VBP
cord-023439-r04y1j22	769	6	new	new	JJ
cord-023439-r04y1j22	769	7	markers	marker	NNS
cord-023439-r04y1j22	769	8	for	for	IN
cord-023439-r04y1j22	769	9	MSC	MSC	NNP
cord-023439-r04y1j22	769	10	in	in	IN
cord-023439-r04y1j22	769	11	cancer	cancer	NN
cord-023439-r04y1j22	769	12	and	and	CC
cord-023439-r04y1j22	769	13	further	further	RB
cord-023439-r04y1j22	769	14	establish	establish	VB
cord-023439-r04y1j22	769	15	their	-PRON-	PRP$
cord-023439-r04y1j22	769	16	M2	M2	NNP
cord-023439-r04y1j22	769	17	activation	activation	NN
cord-023439-r04y1j22	769	18	state	state	NN
cord-023439-r04y1j22	769	19	.	.	.
cord-023439-r04y1j22	770	1	study	study	NN
cord-023439-r04y1j22	770	2	.	.	.
cord-023439-r04y1j22	771	1	Only	only	RB
cord-023439-r04y1j22	771	2	SP	SP	NNP
cord-023439-r04y1j22	771	3	-	-	HYPH
cord-023439-r04y1j22	771	4	A	A	NNP
cord-023439-r04y1j22	771	5	showed	show	VBD
cord-023439-r04y1j22	771	6	a	a	DT
cord-023439-r04y1j22	771	7	significant	significant	JJ
cord-023439-r04y1j22	771	8	expression	expression	NN
cord-023439-r04y1j22	771	9	in	in	IN
cord-023439-r04y1j22	771	10	normal	normal	JJ
cord-023439-r04y1j22	771	11	mucosa	mucosa	NN
cord-023439-r04y1j22	771	12	which	which	WDT
cord-023439-r04y1j22	771	13	was	be	VBD
cord-023439-r04y1j22	771	14	downregulated	downregulate	VBN
cord-023439-r04y1j22	771	15	in	in	IN
cord-023439-r04y1j22	771	16	CRC	CRC	NNP
cord-023439-r04y1j22	771	17	.	.	.
cord-023439-r04y1j22	772	1	As	as	IN
cord-023439-r04y1j22	772	2	the	the	DT
cord-023439-r04y1j22	772	3	absolute	absolute	JJ
cord-023439-r04y1j22	772	4	signal	signal	JJ
cord-023439-r04y1j22	772	5	level	level	NN
cord-023439-r04y1j22	772	6	was	be	VBD
cord-023439-r04y1j22	772	7	below	below	IN
cord-023439-r04y1j22	772	8	the	the	DT
cord-023439-r04y1j22	772	9	noise	noise	NN
cord-023439-r04y1j22	772	10	threshold	threshold	NN
cord-023439-r04y1j22	772	11	,	,	,
cord-023439-r04y1j22	772	12	these	these	DT
cord-023439-r04y1j22	772	13	results	result	NNS
cord-023439-r04y1j22	772	14	have	have	VBP
cord-023439-r04y1j22	772	15	to	to	TO
cord-023439-r04y1j22	772	16	be	be	VB
cord-023439-r04y1j22	772	17	interpreted	interpret	VBN
cord-023439-r04y1j22	772	18	with	with	IN
cord-023439-r04y1j22	772	19	caution	caution	NN
cord-023439-r04y1j22	772	20	and	and	CC
cord-023439-r04y1j22	772	21	require	require	VB
cord-023439-r04y1j22	772	22	confirmation	confirmation	NN
cord-023439-r04y1j22	772	23	by	by	IN
cord-023439-r04y1j22	772	24	direct	direct	NNP
cord-023439-r04y1j22	772	25	measurenment	measurenment	NNP
cord-023439-r04y1j22	772	26	of	of	IN
cord-023439-r04y1j22	772	27	the	the	DT
cord-023439-r04y1j22	772	28	proteins	protein	NNS
cord-023439-r04y1j22	772	29	.	.	.
cord-023439-r04y1j22	773	1	Our	-PRON-	PRP$
cord-023439-r04y1j22	773	2	results	result	NNS
cord-023439-r04y1j22	773	3	suggest	suggest	VBP
cord-023439-r04y1j22	773	4	that	that	IN
cord-023439-r04y1j22	773	5	there	there	EX
cord-023439-r04y1j22	773	6	is	be	VBZ
cord-023439-r04y1j22	773	7	no	no	DT
cord-023439-r04y1j22	773	8	major	major	JJ
cord-023439-r04y1j22	773	9	role	role	NN
cord-023439-r04y1j22	773	10	for	for	IN
cord-023439-r04y1j22	773	11	the	the	DT
cord-023439-r04y1j22	773	12	human	human	JJ
cord-023439-r04y1j22	773	13	collectins	collectin	NNS
cord-023439-r04y1j22	773	14	in	in	IN
cord-023439-r04y1j22	773	15	colorectal	colorectal	JJ
cord-023439-r04y1j22	773	16	cancer	cancer	NN
cord-023439-r04y1j22	773	17	.	.	.
cord-023439-r04y1j22	773	18	 	 	_SP
cord-023439-r04y1j22	774	1	Tetramerization	Tetramerization	NNP
cord-023439-r04y1j22	774	2	is	be	VBZ
cord-023439-r04y1j22	774	3	visualized	visualize	VBN
cord-023439-r04y1j22	774	4	by	by	IN
cord-023439-r04y1j22	774	5	SDS	SDS	NNP
cord-023439-r04y1j22	774	6	-	-	HYPH
cord-023439-r04y1j22	774	7	PAGE	PAGE	NNP
cord-023439-r04y1j22	774	8	.	.	.
cord-023439-r04y1j22	775	1	Conclusion	conclusion	NN
cord-023439-r04y1j22	775	2	:	:	:
cord-023439-r04y1j22	776	1	An	an	DT
cord-023439-r04y1j22	776	2	effective	effective	JJ
cord-023439-r04y1j22	776	3	method	method	NN
cord-023439-r04y1j22	776	4	for	for	IN
cord-023439-r04y1j22	776	5	the	the	DT
cord-023439-r04y1j22	776	6	production	production	NN
cord-023439-r04y1j22	776	7	of	of	IN
cord-023439-r04y1j22	776	8	highly	highly	RB
cord-023439-r04y1j22	776	9	pure	pure	JJ
cord-023439-r04y1j22	776	10	MHC	MHC	NNP
cord-023439-r04y1j22	777	1	I	-PRON-	PRP
cord-023439-r04y1j22	777	2	molecules	molecule	NNS
cord-023439-r04y1j22	777	3	has	have	VBZ
cord-023439-r04y1j22	777	4	been	be	VBN
cord-023439-r04y1j22	777	5	applied	apply	VBN
cord-023439-r04y1j22	777	6	to	to	IN
cord-023439-r04y1j22	777	7	HLA	HLA	NNP
cord-023439-r04y1j22	777	8	-	-	HYPH
cord-023439-r04y1j22	777	9	B*1501	B*1501	NNP
cord-023439-r04y1j22	777	10	and	and	CC
cord-023439-r04y1j22	777	11	HLA	HLA	NNP
cord-023439-r04y1j22	777	12	-	-	HYPH
cord-023439-r04y1j22	777	13	B*5801	B*5801	NNP
cord-023439-r04y1j22	777	14	,	,	,
cord-023439-r04y1j22	777	15	and	and	CC
cord-023439-r04y1j22	777	16	RIA	RIA	NNP
cord-023439-r04y1j22	777	17	and	and	CC
cord-023439-r04y1j22	777	18	ELISA	ELISA	NNP
cord-023439-r04y1j22	777	19	binding	bind	VBG
cord-023439-r04y1j22	777	20	assays	assay	NNS
cord-023439-r04y1j22	777	21	for	for	IN
cord-023439-r04y1j22	777	22	those	those	DT
cord-023439-r04y1j22	777	23	alleles	allele	NNS
cord-023439-r04y1j22	777	24	have	have	VBP
cord-023439-r04y1j22	777	25	been	be	VBN
cord-023439-r04y1j22	777	26	established	establish	VBN
cord-023439-r04y1j22	777	27	Background	background	NN
cord-023439-r04y1j22	777	28	:	:	:
cord-023439-r04y1j22	777	29	Proliferation	proliferation	NN
cord-023439-r04y1j22	777	30	,	,	,
cord-023439-r04y1j22	777	31	differentiation	differentiation	NN
cord-023439-r04y1j22	777	32	and	and	CC
cord-023439-r04y1j22	777	33	apoptosis	apoptosis	NN
cord-023439-r04y1j22	777	34	are	be	VBP
cord-023439-r04y1j22	777	35	essential	essential	JJ
cord-023439-r04y1j22	777	36	processes	process	NNS
cord-023439-r04y1j22	777	37	in	in	IN
cord-023439-r04y1j22	777	38	the	the	DT
cord-023439-r04y1j22	777	39	normal	normal	JJ
cord-023439-r04y1j22	777	40	functions	function	NNS
cord-023439-r04y1j22	777	41	of	of	IN
cord-023439-r04y1j22	777	42	the	the	DT
cord-023439-r04y1j22	777	43	mammary	mammary	JJ
cord-023439-r04y1j22	777	44	epithelium	epithelium	NN
cord-023439-r04y1j22	777	45	.	.	.
cord-023439-r04y1j22	778	1	The	the	DT
cord-023439-r04y1j22	778	2	hypothesis	hypothesis	NN
cord-023439-r04y1j22	778	3	examined	examine	VBD
cord-023439-r04y1j22	778	4	in	in	IN
cord-023439-r04y1j22	778	5	this	this	DT
cord-023439-r04y1j22	778	6	study	study	NN
cord-023439-r04y1j22	778	7	is	be	VBZ
cord-023439-r04y1j22	778	8	that	that	IN
cord-023439-r04y1j22	778	9	the	the	DT
cord-023439-r04y1j22	778	10	transcription	transcription	NN
cord-023439-r04y1j22	778	11	factor	factor	NN
cord-023439-r04y1j22	778	12	BCL-6	BCL-6	NNP
cord-023439-r04y1j22	778	13	is	be	VBZ
cord-023439-r04y1j22	778	14	critically	critically	RB
cord-023439-r04y1j22	778	15	important	important	JJ
cord-023439-r04y1j22	778	16	not	not	RB
cord-023439-r04y1j22	778	17	only	only	RB
cord-023439-r04y1j22	778	18	for	for	IN
cord-023439-r04y1j22	778	19	regulating	regulate	VBG
cord-023439-r04y1j22	778	20	B	b	NN
cord-023439-r04y1j22	778	21	-	-	HYPH
cord-023439-r04y1j22	778	22	cell	cell	NN
cord-023439-r04y1j22	778	23	growth	growth	NN
cord-023439-r04y1j22	778	24	and	and	CC
cord-023439-r04y1j22	778	25	development	development	NN
cord-023439-r04y1j22	778	26	but	but	CC
cord-023439-r04y1j22	778	27	also	also	RB
cord-023439-r04y1j22	778	28	for	for	IN
cord-023439-r04y1j22	778	29	mammary	mammary	JJ
cord-023439-r04y1j22	778	30	epithelial	epithelial	JJ
cord-023439-r04y1j22	778	31	apoptosis	apoptosis	NN
cord-023439-r04y1j22	778	32	.	.	.
cord-023439-r04y1j22	779	1	Methodology	methodology	NN
cord-023439-r04y1j22	779	2	:	:	:
cord-023439-r04y1j22	780	1	Twenty	twenty	CD
cord-023439-r04y1j22	780	2	breast	breast	NN
cord-023439-r04y1j22	780	3	cancer	cancer	NN
cord-023439-r04y1j22	780	4	cases	case	NNS
cord-023439-r04y1j22	780	5	and	and	CC
cord-023439-r04y1j22	780	6	31	31	CD
cord-023439-r04y1j22	780	7	healthy	healthy	JJ
cord-023439-r04y1j22	780	8	controls	control	NNS
cord-023439-r04y1j22	780	9	were	be	VBD
cord-023439-r04y1j22	780	10	used	use	VBN
cord-023439-r04y1j22	780	11	to	to	TO
cord-023439-r04y1j22	780	12	investigate	investigate	VB
cord-023439-r04y1j22	780	13	whether	whether	IN
cord-023439-r04y1j22	780	14	BCL-6	BCL-6	NNP
cord-023439-r04y1j22	780	15	protein	protein	NN
cord-023439-r04y1j22	780	16	in	in	IN
cord-023439-r04y1j22	780	17	involved	involve	VBN
cord-023439-r04y1j22	780	18	in	in	IN
cord-023439-r04y1j22	780	19	breast	breast	NN
cord-023439-r04y1j22	780	20	cancer	cancer	NN
cord-023439-r04y1j22	780	21	(	(	-LRB-
cord-023439-r04y1j22	780	22	grade	grade	NN
cord-023439-r04y1j22	780	23	III	III	NNP
cord-023439-r04y1j22	780	24	)	)	-RRB-
cord-023439-r04y1j22	780	25	.	.	.
cord-023439-r04y1j22	781	1	Full	full	JJ
cord-023439-r04y1j22	781	2	length	length	NN
cord-023439-r04y1j22	782	1	BCL-6	BCL-6	NNP
cord-023439-r04y1j22	782	2	cDNA	cdna	NN
cord-023439-r04y1j22	782	3	was	be	VBD
cord-023439-r04y1j22	782	4	retrovirally	retrovirally	RB
cord-023439-r04y1j22	782	5	transduced	transduce	VBN
cord-023439-r04y1j22	782	6	into	into	IN
cord-023439-r04y1j22	782	7	EpH-4	EpH-4	NNP
cord-023439-r04y1j22	782	8	cell	cell	NN
cord-023439-r04y1j22	782	9	line	line	NN
cord-023439-r04y1j22	782	10	.	.	.
cord-023439-r04y1j22	783	1	We	-PRON-	PRP
cord-023439-r04y1j22	783	2	then	then	RB
cord-023439-r04y1j22	783	3	used	use	VBD
cord-023439-r04y1j22	783	4	flow	flow	NN
cord-023439-r04y1j22	783	5	cytometry	cytometry	NN
cord-023439-r04y1j22	783	6	of	of	IN
cord-023439-r04y1j22	783	7	BrdUrd	BrdUrd	NNP
cord-023439-r04y1j22	783	8	-	-	HYPH
cord-023439-r04y1j22	783	9	stained	stain	VBN
cord-023439-r04y1j22	783	10	cells	cell	NNS
cord-023439-r04y1j22	783	11	to	to	TO
cord-023439-r04y1j22	783	12	investigate	investigate	VB
cord-023439-r04y1j22	783	13	the	the	DT
cord-023439-r04y1j22	783	14	cell	cell	NN
cord-023439-r04y1j22	783	15	-	-	HYPH
cord-023439-r04y1j22	783	16	cycle	cycle	NN
cord-023439-r04y1j22	783	17	duration	duration	NN
cord-023439-r04y1j22	783	18	of	of	IN
cord-023439-r04y1j22	783	19	the	the	DT
cord-023439-r04y1j22	783	20	control	control	NN
cord-023439-r04y1j22	783	21	and	and	CC
cord-023439-r04y1j22	783	22	transduced	transduce	VBD
cord-023439-r04y1j22	783	23	cell	cell	NN
cord-023439-r04y1j22	783	24	lines	line	NNS
cord-023439-r04y1j22	783	25	.	.	.
cord-023439-r04y1j22	784	1	TUNEL	TUNEL	NNP
cord-023439-r04y1j22	784	2	was	be	VBD
cord-023439-r04y1j22	784	3	used	use	VBN
cord-023439-r04y1j22	784	4	as	as	IN
cord-023439-r04y1j22	784	5	a	a	DT
cord-023439-r04y1j22	784	6	marker	marker	NN
cord-023439-r04y1j22	784	7	of	of	IN
cord-023439-r04y1j22	784	8	apoptosis	apoptosis	NN
cord-023439-r04y1j22	784	9	to	to	TO
cord-023439-r04y1j22	784	10	find	find	VB
cord-023439-r04y1j22	784	11	out	out	RP
cord-023439-r04y1j22	784	12	differences	difference	NNS
cord-023439-r04y1j22	784	13	in	in	IN
cord-023439-r04y1j22	784	14	the	the	DT
cord-023439-r04y1j22	784	15	frequencies	frequency	NNS
cord-023439-r04y1j22	784	16	of	of	IN
cord-023439-r04y1j22	784	17	apoptotic	apoptotic	JJ
cord-023439-r04y1j22	784	18	cells	cell	NNS
cord-023439-r04y1j22	784	19	in	in	IN
cord-023439-r04y1j22	784	20	the	the	DT
cord-023439-r04y1j22	784	21	control	control	NN
cord-023439-r04y1j22	784	22	and	and	CC
cord-023439-r04y1j22	784	23	transduced	transduce	VBD
cord-023439-r04y1j22	784	24	cell	cell	NN
cord-023439-r04y1j22	784	25	lines	line	NNS
cord-023439-r04y1j22	784	26	.	.	.
cord-023439-r04y1j22	785	1	Finally	finally	RB
cord-023439-r04y1j22	785	2	,	,	,
cord-023439-r04y1j22	785	3	immunohistochemistry	immunohistochemistry	NN
cord-023439-r04y1j22	785	4	staining	staining	NN
cord-023439-r04y1j22	785	5	was	be	VBD
cord-023439-r04y1j22	785	6	performed	perform	VBN
cord-023439-r04y1j22	785	7	to	to	TO
cord-023439-r04y1j22	785	8	detect	detect	VB
cord-023439-r04y1j22	785	9	BCL-6	BCL-6	NNP
cord-023439-r04y1j22	785	10	in	in	IN
cord-023439-r04y1j22	785	11	breast	breast	NN
cord-023439-r04y1j22	785	12	cancer	cancer	NN
cord-023439-r04y1j22	785	13	(	(	-LRB-
cord-023439-r04y1j22	785	14	III	III	NNP
cord-023439-r04y1j22	785	15	)	)	-RRB-
cord-023439-r04y1j22	785	16	.	.	.
cord-023439-r04y1j22	786	1	Results	result	NNS
cord-023439-r04y1j22	786	2	:	:	:
cord-023439-r04y1j22	786	3	Restoration	restoration	NN
cord-023439-r04y1j22	786	4	of	of	IN
cord-023439-r04y1j22	786	5	BCL-6	BCL-6	NNP
cord-023439-r04y1j22	786	6	into	into	IN
cord-023439-r04y1j22	786	7	EpH-4	EpH-4	NNP
cord-023439-r04y1j22	786	8	cells	cell	NNS
cord-023439-r04y1j22	787	1	not	not	RB
cord-023439-r04y1j22	787	2	only	only	RB
cord-023439-r04y1j22	787	3	inhibits	inhibit	VBZ
cord-023439-r04y1j22	787	4	apoptosis	apoptosis	NN
cord-023439-r04y1j22	787	5	but	but	CC
cord-023439-r04y1j22	787	6	also	also	RB
cord-023439-r04y1j22	787	7	prolongs	prolong	VBZ
cord-023439-r04y1j22	787	8	the	the	DT
cord-023439-r04y1j22	787	9	cell	cell	NN
cord-023439-r04y1j22	787	10	cycle	cycle	NN
cord-023439-r04y1j22	787	11	and	and	CC
cord-023439-r04y1j22	787	12	results	result	NNS
cord-023439-r04y1j22	787	13	in	in	IN
cord-023439-r04y1j22	787	14	increased	increase	VBN
cord-023439-r04y1j22	787	15	cell	cell	NN
cord-023439-r04y1j22	787	16	size	size	NN
cord-023439-r04y1j22	787	17	and	and	CC
cord-023439-r04y1j22	787	18	protein	protein	NN
cord-023439-r04y1j22	787	19	content	content	NN
cord-023439-r04y1j22	787	20	.	.	.
cord-023439-r04y1j22	788	1	The	the	DT
cord-023439-r04y1j22	788	2	results	result	NNS
cord-023439-r04y1j22	788	3	also	also	RB
cord-023439-r04y1j22	788	4	indicated	indicate	VBD
cord-023439-r04y1j22	788	5	that	that	IN
cord-023439-r04y1j22	788	6	the	the	DT
cord-023439-r04y1j22	788	7	cell	cell	NN
cord-023439-r04y1j22	788	8	-	-	HYPH
cord-023439-r04y1j22	788	9	cycle	cycle	NN
cord-023439-r04y1j22	788	10	time	time	NN
cord-023439-r04y1j22	788	11	of	of	IN
cord-023439-r04y1j22	788	12	BCL-6-transduced	BCL-6-transduced	NNP
cord-023439-r04y1j22	788	13	EpH-4	EpH-4	NNP
cord-023439-r04y1j22	788	14	cells	cell	NNS
cord-023439-r04y1j22	788	15	is	be	VBZ
cord-023439-r04y1j22	788	16	prolonged	prolong	VBN
cord-023439-r04y1j22	788	17	by	by	IN
cord-023439-r04y1j22	788	18	about	about	RB
cord-023439-r04y1j22	788	19	3	3	CD
cord-023439-r04y1j22	788	20	h	h	NN
cord-023439-r04y1j22	788	21	,	,	,
cord-023439-r04y1j22	788	22	presumably	presumably	RB
cord-023439-r04y1j22	788	23	as	as	IN
cord-023439-r04y1j22	788	24	a	a	DT
cord-023439-r04y1j22	788	25	result	result	NN
cord-023439-r04y1j22	788	26	of	of	IN
cord-023439-r04y1j22	788	27	the	the	DT
cord-023439-r04y1j22	788	28	action	action	NN
cord-023439-r04y1j22	788	29	of	of	IN
cord-023439-r04y1j22	788	30	BCL-6	BCL-6	NNP
cord-023439-r04y1j22	788	31	at	at	IN
cord-023439-r04y1j22	788	32	the	the	DT
cord-023439-r04y1j22	788	33	BCL-6	BCL-6	NNP
cord-023439-r04y1j22	788	34	at	at	IN
cord-023439-r04y1j22	788	35	the	the	DT
cord-023439-r04y1j22	788	36	G1	G1	NNP
cord-023439-r04y1j22	788	37	/	/	SYM
cord-023439-r04y1j22	788	38	S	S	NNP
cord-023439-r04y1j22	788	39	transition	transition	NN
cord-023439-r04y1j22	788	40	.	.	.
cord-023439-r04y1j22	789	1	We	-PRON-	PRP
cord-023439-r04y1j22	789	2	found	find	VBD
cord-023439-r04y1j22	789	3	differences	difference	NNS
cord-023439-r04y1j22	789	4	in	in	IN
cord-023439-r04y1j22	789	5	the	the	DT
cord-023439-r04y1j22	789	6	frequencies	frequency	NNS
cord-023439-r04y1j22	789	7	of	of	IN
cord-023439-r04y1j22	789	8	viable	viable	JJ
cord-023439-r04y1j22	789	9	and	and	CC
cord-023439-r04y1j22	789	10	apoptotic	apoptotic	JJ
cord-023439-r04y1j22	789	11	cells	cell	NNS
cord-023439-r04y1j22	789	12	in	in	IN
cord-023439-r04y1j22	789	13	cultures	culture	NNS
cord-023439-r04y1j22	789	14	of	of	IN
cord-023439-r04y1j22	789	15	the	the	DT
cord-023439-r04y1j22	789	16	parent	parent	NN
cord-023439-r04y1j22	789	17	EpH-4	eph-4	PRP
cord-023439-r04y1j22	789	18	cells	cell	NNS
cord-023439-r04y1j22	789	19	,	,	,
cord-023439-r04y1j22	789	20	control	control	NN
cord-023439-r04y1j22	789	21	-	-	HYPH
cord-023439-r04y1j22	789	22	transduced	transduce	VBN
cord-023439-r04y1j22	789	23	EpH-4	EpH-4	NNP
cord-023439-r04y1j22	789	24	cells	cell	NNS
cord-023439-r04y1j22	789	25	and	and	CC
cord-023439-r04y1j22	789	26	BCL-6-transduced	BCL-6-transduced	NNP
cord-023439-r04y1j22	789	27	EpH-4	EpH-4	NNP
cord-023439-r04y1j22	789	28	cells	cell	NNS
cord-023439-r04y1j22	789	29	.	.	.
cord-023439-r04y1j22	790	1	Consistently	consistently	RB
cord-023439-r04y1j22	790	2	,	,	,
cord-023439-r04y1j22	790	3	we	-PRON-	PRP
cord-023439-r04y1j22	790	4	demonstrated	demonstrate	VBD
cord-023439-r04y1j22	790	5	that	that	IN
cord-023439-r04y1j22	790	6	BCL-6	BCL-6	NNP
cord-023439-r04y1j22	790	7	is	be	VBZ
cord-023439-r04y1j22	790	8	expressed	express	VBN
cord-023439-r04y1j22	790	9	in	in	IN
cord-023439-r04y1j22	790	10	90	90	CD
cord-023439-r04y1j22	790	11	%	%	NN
cord-023439-r04y1j22	790	12	of	of	IN
cord-023439-r04y1j22	790	13	high	high	JJ
cord-023439-r04y1j22	790	14	grade	grade	NN
cord-023439-r04y1j22	790	15	of	of	IN
cord-023439-r04y1j22	790	16	breast	breast	NN
cord-023439-r04y1j22	790	17	carcinoma	carcinoma	NN
cord-023439-r04y1j22	790	18	,	,	,
cord-023439-r04y1j22	790	19	which	which	WDT
cord-023439-r04y1j22	790	20	is	be	VBZ
cord-023439-r04y1j22	790	21	considered	consider	VBN
cord-023439-r04y1j22	790	22	as	as	IN
cord-023439-r04y1j22	790	23	the	the	DT
cord-023439-r04y1j22	790	24	most	most	RBS
cord-023439-r04y1j22	790	25	aggressive	aggressive	JJ
cord-023439-r04y1j22	790	26	of	of	IN
cord-023439-r04y1j22	790	27	tumours	tumour	NNS
cord-023439-r04y1j22	790	28	.	.	.
cord-023439-r04y1j22	791	1	Conclusion	conclusion	NN
cord-023439-r04y1j22	791	2	:	:	:
cord-023439-r04y1j22	792	1	Together	together	RB
cord-023439-r04y1j22	792	2	,	,	,
cord-023439-r04y1j22	792	3	these	these	DT
cord-023439-r04y1j22	792	4	results	result	NNS
cord-023439-r04y1j22	792	5	suggest	suggest	VBP
cord-023439-r04y1j22	792	6	that	that	IN
cord-023439-r04y1j22	792	7	BCL-6	BCL-6	NNP
cord-023439-r04y1j22	792	8	is	be	VBZ
cord-023439-r04y1j22	792	9	likely	likely	JJ
cord-023439-r04y1j22	792	10	to	to	TO
cord-023439-r04y1j22	792	11	be	be	VB
cord-023439-r04y1j22	792	12	involved	involve	VBN
cord-023439-r04y1j22	792	13	in	in	IN
cord-023439-r04y1j22	792	14	mammary	mammary	JJ
cord-023439-r04y1j22	792	15	gland	gland	NN
cord-023439-r04y1j22	792	16	development	development	NN
cord-023439-r04y1j22	792	17	and	and	CC
cord-023439-r04y1j22	792	18	carcinogenesis	carcinogenesis	NN
cord-023439-r04y1j22	792	19	.	.	.
cord-023439-r04y1j22	793	1	Inflammatory	inflammatory	JJ
cord-023439-r04y1j22	793	2	cytokines	cytokine	NNS
cord-023439-r04y1j22	793	3	have	have	VBP
cord-023439-r04y1j22	793	4	a	a	DT
cord-023439-r04y1j22	793	5	critical	critical	JJ
cord-023439-r04y1j22	793	6	role	role	NN
cord-023439-r04y1j22	793	7	in	in	IN
cord-023439-r04y1j22	793	8	modulation	modulation	NN
cord-023439-r04y1j22	793	9	of	of	IN
cord-023439-r04y1j22	793	10	both	both	DT
cord-023439-r04y1j22	793	11	innate	innate	JJ
cord-023439-r04y1j22	793	12	and	and	CC
cord-023439-r04y1j22	793	13	adaptive	adaptive	JJ
cord-023439-r04y1j22	793	14	immunity	immunity	NN
cord-023439-r04y1j22	793	15	in	in	IN
cord-023439-r04y1j22	793	16	response	response	NN
cord-023439-r04y1j22	793	17	to	to	IN
cord-023439-r04y1j22	793	18	foreign	foreign	JJ
cord-023439-r04y1j22	793	19	antigen	antigen	NN
cord-023439-r04y1j22	793	20	.	.	.
cord-023439-r04y1j22	794	1	They	-PRON-	PRP
cord-023439-r04y1j22	794	2	also	also	RB
cord-023439-r04y1j22	794	3	play	play	VBP
cord-023439-r04y1j22	794	4	an	an	DT
cord-023439-r04y1j22	794	5	important	important	JJ
cord-023439-r04y1j22	794	6	role	role	NN
cord-023439-r04y1j22	794	7	in	in	IN
cord-023439-r04y1j22	794	8	anticancer	anticancer	JJ
cord-023439-r04y1j22	794	9	immunity	immunity	NN
cord-023439-r04y1j22	794	10	.	.	.
cord-023439-r04y1j22	795	1	For	for	IN
cord-023439-r04y1j22	795	2	example	example	NN
cord-023439-r04y1j22	795	3	,	,	,
cord-023439-r04y1j22	795	4	they	-PRON-	PRP
cord-023439-r04y1j22	795	5	can	can	MD
cord-023439-r04y1j22	795	6	promote	promote	VB
cord-023439-r04y1j22	795	7	cell	cell	NN
cord-023439-r04y1j22	795	8	-	-	HYPH
cord-023439-r04y1j22	795	9	mediated	mediate	VBN
cord-023439-r04y1j22	795	10	immunity	immunity	NN
cord-023439-r04y1j22	795	11	against	against	IN
cord-023439-r04y1j22	795	12	cancer	cancer	NN
cord-023439-r04y1j22	795	13	cells	cell	NNS
cord-023439-r04y1j22	795	14	.	.	.
cord-023439-r04y1j22	796	1	With	with	IN
cord-023439-r04y1j22	796	2	their	-PRON-	PRP$
cord-023439-r04y1j22	796	3	immunostimulatory	immunostimulatory	NN
cord-023439-r04y1j22	796	4	effects	effect	NNS
cord-023439-r04y1j22	796	5	,	,	,
cord-023439-r04y1j22	796	6	these	these	DT
cord-023439-r04y1j22	796	7	cytokines	cytokine	NNS
cord-023439-r04y1j22	796	8	are	be	VBP
cord-023439-r04y1j22	796	9	being	be	VBG
cord-023439-r04y1j22	796	10	tested	test	VBN
cord-023439-r04y1j22	796	11	for	for	IN
cord-023439-r04y1j22	796	12	cancer	cancer	NN
cord-023439-r04y1j22	796	13	treatment	treatment	NN
cord-023439-r04y1j22	796	14	in	in	IN
cord-023439-r04y1j22	796	15	the	the	DT
cord-023439-r04y1j22	796	16	form	form	NN
cord-023439-r04y1j22	796	17	of	of	IN
cord-023439-r04y1j22	796	18	DNA	dna	NN
cord-023439-r04y1j22	796	19	vaccine	vaccine	NN
cord-023439-r04y1j22	796	20	or	or	CC
cord-023439-r04y1j22	796	21	adjuvant	adjuvant	JJ
cord-023439-r04y1j22	796	22	or	or	CC
cord-023439-r04y1j22	796	23	therapeutic	therapeutic	JJ
cord-023439-r04y1j22	796	24	cytokines	cytokine	NNS
cord-023439-r04y1j22	796	25	.	.	.
cord-023439-r04y1j22	797	1	Direct	direct	JJ
cord-023439-r04y1j22	797	2	effect	effect	NN
cord-023439-r04y1j22	797	3	of	of	IN
cord-023439-r04y1j22	797	4	these	these	DT
cord-023439-r04y1j22	797	5	cytokines	cytokine	NNS
cord-023439-r04y1j22	797	6	on	on	IN
cord-023439-r04y1j22	797	7	cancer	cancer	NN
cord-023439-r04y1j22	797	8	cell	cell	NN
cord-023439-r04y1j22	797	9	,	,	,
cord-023439-r04y1j22	797	10	however	however	RB
cord-023439-r04y1j22	797	11	,	,	,
cord-023439-r04y1j22	797	12	is	be	VBZ
cord-023439-r04y1j22	797	13	still	still	RB
cord-023439-r04y1j22	797	14	unclear	unclear	JJ
cord-023439-r04y1j22	797	15	.	.	.
cord-023439-r04y1j22	798	1	In	in	IN
cord-023439-r04y1j22	798	2	this	this	DT
cord-023439-r04y1j22	798	3	project	project	NN
cord-023439-r04y1j22	798	4	,	,	,
cord-023439-r04y1j22	798	5	we	-PRON-	PRP
cord-023439-r04y1j22	798	6	investigated	investigate	VBD
cord-023439-r04y1j22	798	7	whether	whether	IN
cord-023439-r04y1j22	798	8	IL-1	IL-1	NNP
cord-023439-r04y1j22	798	9	(	(	-LRB-
cord-023439-r04y1j22	798	10	and	and	CC
cord-023439-r04y1j22	798	11	IL-18	IL-18	NNP
cord-023439-r04y1j22	798	12	can	can	MD
cord-023439-r04y1j22	798	13	modulate	modulate	VB
cord-023439-r04y1j22	798	14	cancer	cancer	NN
cord-023439-r04y1j22	798	15	cell	cell	NN
cord-023439-r04y1j22	798	16	proliferation	proliferation	NN
cord-023439-r04y1j22	798	17	.	.	.
cord-023439-r04y1j22	799	1	We	-PRON-	PRP
cord-023439-r04y1j22	799	2	employed	employ	VBD
cord-023439-r04y1j22	799	3	a	a	DT
cord-023439-r04y1j22	799	4	simple	simple	JJ
cord-023439-r04y1j22	799	5	nonradioactive	nonradioactive	JJ
cord-023439-r04y1j22	799	6	proliferation	proliferation	NN
cord-023439-r04y1j22	799	7	(	(	-LRB-
cord-023439-r04y1j22	799	8	MTT	MTT	NNP
cord-023439-r04y1j22	799	9	)	)	-RRB-
cord-023439-r04y1j22	799	10	assay	assay	NN
cord-023439-r04y1j22	799	11	and	and	CC
cord-023439-r04y1j22	799	12	detection	detection	NN
cord-023439-r04y1j22	799	13	of	of	IN
cord-023439-r04y1j22	799	14	lactate	lactate	NN
cord-023439-r04y1j22	799	15	dehydrogenase	dehydrogenase	NN
cord-023439-r04y1j22	799	16	(	(	-LRB-
cord-023439-r04y1j22	799	17	LDH	LDH	NNP
cord-023439-r04y1j22	799	18	)	)	-RRB-
cord-023439-r04y1j22	799	19	to	to	TO
cord-023439-r04y1j22	799	20	test	test	VB
cord-023439-r04y1j22	799	21	the	the	DT
cord-023439-r04y1j22	799	22	effect	effect	NN
cord-023439-r04y1j22	799	23	of	of	IN
cord-023439-r04y1j22	799	24	these	these	DT
cord-023439-r04y1j22	799	25	recombinant	recombinant	JJ
cord-023439-r04y1j22	799	26	human	human	JJ
cord-023439-r04y1j22	799	27	cytokines	cytokine	NNS
cord-023439-r04y1j22	799	28	on	on	IN
cord-023439-r04y1j22	799	29	various	various	JJ
cord-023439-r04y1j22	799	30	cancer	cancer	NN
cord-023439-r04y1j22	799	31	cell	cell	NN
cord-023439-r04y1j22	799	32	lines	line	NNS
cord-023439-r04y1j22	799	33	,	,	,
cord-023439-r04y1j22	799	34	including	include	VBG
cord-023439-r04y1j22	799	35	breast	breast	NN
cord-023439-r04y1j22	799	36	cancer	cancer	NN
cord-023439-r04y1j22	799	37	cell	cell	NN
cord-023439-r04y1j22	799	38	line	line	NN
cord-023439-r04y1j22	799	39	(	(	-LRB-
cord-023439-r04y1j22	799	40	MCF-7	MCF-7	NNP
cord-023439-r04y1j22	799	41	)	)	-RRB-
cord-023439-r04y1j22	799	42	,	,	,
cord-023439-r04y1j22	799	43	oral	oral	JJ
cord-023439-r04y1j22	799	44	carcinoma	carcinoma	NN
cord-023439-r04y1j22	799	45	cell	cell	NN
cord-023439-r04y1j22	799	46	line	line	NN
cord-023439-r04y1j22	799	47	(	(	-LRB-
cord-023439-r04y1j22	799	48	KB	KB	NNP
cord-023439-r04y1j22	799	49	)	)	-RRB-
cord-023439-r04y1j22	799	50	,	,	,
cord-023439-r04y1j22	799	51	colon	colon	NN
cord-023439-r04y1j22	799	52	cancer	cancer	NN
cord-023439-r04y1j22	799	53	cell	cell	NN
cord-023439-r04y1j22	799	54	line	line	NN
cord-023439-r04y1j22	799	55	(	(	-LRB-
cord-023439-r04y1j22	799	56	Caco-2	Caco-2	NNP
cord-023439-r04y1j22	799	57	)	)	-RRB-
cord-023439-r04y1j22	799	58	and	and	CC
cord-023439-r04y1j22	799	59	choriocarcinoma	choriocarcinoma	NN
cord-023439-r04y1j22	799	60	cell	cell	NN
cord-023439-r04y1j22	799	61	line	line	NN
cord-023439-r04y1j22	799	62	(	(	-LRB-
cord-023439-r04y1j22	799	63	Jar	jar	NN
cord-023439-r04y1j22	799	64	)	)	-RRB-
cord-023439-r04y1j22	799	65	.	.	.
cord-023439-r04y1j22	800	1	Cytokines	cytokine	NNS
cord-023439-r04y1j22	800	2	used	use	VBN
cord-023439-r04y1j22	800	3	in	in	IN
cord-023439-r04y1j22	800	4	this	this	DT
cord-023439-r04y1j22	800	5	study	study	NN
cord-023439-r04y1j22	800	6	had	have	VBD
cord-023439-r04y1j22	800	7	both	both	DT
cord-023439-r04y1j22	800	8	inhibitory	inhibitory	JJ
cord-023439-r04y1j22	800	9	and	and	CC
cord-023439-r04y1j22	800	10	stimulatory	stimulatory	JJ
cord-023439-r04y1j22	800	11	effect	effect	NN
cord-023439-r04y1j22	800	12	on	on	IN
cord-023439-r04y1j22	800	13	cell	cell	NN
cord-023439-r04y1j22	800	14	proliferation	proliferation	NN
cord-023439-r04y1j22	800	15	.	.	.
cord-023439-r04y1j22	801	1	Findings	finding	NNS
cord-023439-r04y1j22	801	2	in	in	IN
cord-023439-r04y1j22	801	3	this	this	DT
cord-023439-r04y1j22	801	4	project	project	NN
cord-023439-r04y1j22	801	5	could	could	MD
cord-023439-r04y1j22	801	6	provide	provide	VB
cord-023439-r04y1j22	801	7	an	an	DT
cord-023439-r04y1j22	801	8	insight	insight	NN
cord-023439-r04y1j22	801	9	of	of	IN
cord-023439-r04y1j22	801	10	cancer	cancer	NN
cord-023439-r04y1j22	801	11	cell	cell	NN
cord-023439-r04y1j22	801	12	response	response	NN
cord-023439-r04y1j22	801	13	to	to	IN
cord-023439-r04y1j22	801	14	these	these	DT
cord-023439-r04y1j22	801	15	cytokines	cytokine	NNS
cord-023439-r04y1j22	801	16	and	and	CC
cord-023439-r04y1j22	801	17	this	this	DT
cord-023439-r04y1j22	801	18	could	could	MD
cord-023439-r04y1j22	801	19	lead	lead	VB
cord-023439-r04y1j22	801	20	to	to	IN
cord-023439-r04y1j22	801	21	a	a	DT
cord-023439-r04y1j22	801	22	consideration	consideration	NN
cord-023439-r04y1j22	801	23	on	on	IN
cord-023439-r04y1j22	801	24	using	use	VBG
cord-023439-r04y1j22	801	25	cytokine	cytokine	NN
cord-023439-r04y1j22	801	26	as	as	IN
cord-023439-r04y1j22	801	27	immunotherapy	immunotherapy	NN
cord-023439-r04y1j22	801	28	for	for	IN
cord-023439-r04y1j22	801	29	cancer	cancer	NN
cord-023439-r04y1j22	801	30	treatment	treatment	NN
cord-023439-r04y1j22	801	31	.	.	.
cord-023439-r04y1j22	802	1	Capacity	capacity	NN
cord-023439-r04y1j22	802	2	of	of	IN
cord-023439-r04y1j22	802	3	AE	AE	NNP
cord-023439-r04y1j22	802	4	to	to	TO
cord-023439-r04y1j22	802	5	Modulate	modulate	VB
cord-023439-r04y1j22	802	6	Nitric	nitric	NN
cord-023439-r04y1j22	802	7	Oxide	oxide	NN
cord-023439-r04y1j22	802	8	Production	production	NN
cord-023439-r04y1j22	802	9	Depended	depend	VBD
cord-023439-r04y1j22	802	10	on	on	IN
cord-023439-r04y1j22	802	11	Intercellular	Intercellular	NNP
cord-023439-r04y1j22	802	12	Contact	Contact	NNP
cord-023439-r04y1j22	802	13	donor	donor	NN
cord-023439-r04y1j22	802	14	T	t	NN
cord-023439-r04y1j22	802	15	cells	cell	NNS
cord-023439-r04y1j22	802	16	are	be	VBP
cord-023439-r04y1j22	802	17	involved	involve	VBN
cord-023439-r04y1j22	802	18	in	in	IN
cord-023439-r04y1j22	802	19	the	the	DT
cord-023439-r04y1j22	802	20	antitumour	antitumour	JJ
cord-023439-r04y1j22	802	21	effects	effect	NNS
cord-023439-r04y1j22	802	22	observed	observe	VBN
cord-023439-r04y1j22	802	23	after	after	IN
cord-023439-r04y1j22	802	24	BMT	BMT	NNP
cord-023439-r04y1j22	802	25	.	.	.
cord-023439-r04y1j22	803	1	Thus	thus	RB
cord-023439-r04y1j22	803	2	,	,	,
cord-023439-r04y1j22	803	3	patients	patient	NNS
cord-023439-r04y1j22	803	4	receiving	receive	VBG
cord-023439-r04y1j22	803	5	T	T	NNP
cord-023439-r04y1j22	803	6	-	-	HYPH
cord-023439-r04y1j22	803	7	celldepleted	celldeplete	VBN
cord-023439-r04y1j22	803	8	BMT	BMT	NNP
cord-023439-r04y1j22	803	9	have	have	VBP
cord-023439-r04y1j22	803	10	a	a	DT
cord-023439-r04y1j22	803	11	higher	high	JJR
cord-023439-r04y1j22	803	12	risk	risk	NN
cord-023439-r04y1j22	803	13	of	of	IN
cord-023439-r04y1j22	803	14	leukaemia	leukaemia	NN
cord-023439-r04y1j22	803	15	relapse	relapse	NN
cord-023439-r04y1j22	803	16	compared	compare	VBN
cord-023439-r04y1j22	803	17	to	to	IN
cord-023439-r04y1j22	803	18	patients	patient	NNS
cord-023439-r04y1j22	803	19	receiving	receive	VBG
cord-023439-r04y1j22	803	20	nonmanipulated	nonmanipulate	VBN
cord-023439-r04y1j22	803	21	BMT	BMT	NNP
cord-023439-r04y1j22	803	22	,	,	,
cord-023439-r04y1j22	803	23	and	and	CC
cord-023439-r04y1j22	803	24	patients	patient	NNS
cord-023439-r04y1j22	803	25	experiencing	experience	VBG
cord-023439-r04y1j22	803	26	graft	graft	NN
cord-023439-r04y1j22	803	27	-	-	HYPH
cord-023439-r04y1j22	803	28	versus	versus	IN
cord-023439-r04y1j22	803	29	-	-	HYPH
cord-023439-r04y1j22	803	30	host	host	NN
cord-023439-r04y1j22	803	31	disease	disease	NN
cord-023439-r04y1j22	803	32	(	(	-LRB-
cord-023439-r04y1j22	803	33	GVHD	GVHD	NNP
cord-023439-r04y1j22	803	34	)	)	-RRB-
cord-023439-r04y1j22	803	35	have	have	VBP
cord-023439-r04y1j22	803	36	a	a	DT
cord-023439-r04y1j22	803	37	lower	low	JJR
cord-023439-r04y1j22	803	38	risk	risk	NN
cord-023439-r04y1j22	803	39	of	of	IN
cord-023439-r04y1j22	803	40	disease	disease	NN
cord-023439-r04y1j22	803	41	relapse	relapse	NN
cord-023439-r04y1j22	803	42	than	than	IN
cord-023439-r04y1j22	803	43	patients	patient	NNS
cord-023439-r04y1j22	803	44	who	who	WP
cord-023439-r04y1j22	803	45	do	do	VBP
cord-023439-r04y1j22	803	46	not	not	RB
cord-023439-r04y1j22	803	47	experience	experience	VB
cord-023439-r04y1j22	803	48	GVHD	GVHD	NNP
cord-023439-r04y1j22	803	49	.	.	.
cord-023439-r04y1j22	804	1	Although	although	IN
cord-023439-r04y1j22	804	2	the	the	DT
cord-023439-r04y1j22	804	3	importance	importance	NN
cord-023439-r04y1j22	804	4	of	of	IN
cord-023439-r04y1j22	804	5	donor	donor	NN
cord-023439-r04y1j22	804	6	T	t	NN
cord-023439-r04y1j22	804	7	cells	cell	NNS
cord-023439-r04y1j22	804	8	for	for	IN
cord-023439-r04y1j22	804	9	the	the	DT
cord-023439-r04y1j22	804	10	curative	curative	JJ
cord-023439-r04y1j22	804	11	action	action	NN
cord-023439-r04y1j22	804	12	of	of	IN
cord-023439-r04y1j22	804	13	BMT	BMT	NNP
cord-023439-r04y1j22	804	14	has	have	VBZ
cord-023439-r04y1j22	804	15	been	be	VBN
cord-023439-r04y1j22	804	16	established	establish	VBN
cord-023439-r04y1j22	804	17	,	,	,
cord-023439-r04y1j22	804	18	the	the	DT
cord-023439-r04y1j22	804	19	exact	exact	JJ
cord-023439-r04y1j22	804	20	mechanisms	mechanism	NNS
cord-023439-r04y1j22	804	21	and	and	CC
cord-023439-r04y1j22	804	22	molecules	molecule	NNS
cord-023439-r04y1j22	804	23	involved	involve	VBN
cord-023439-r04y1j22	804	24	in	in	IN
cord-023439-r04y1j22	804	25	this	this	DT
cord-023439-r04y1j22	804	26	graft	graft	NN
cord-023439-r04y1j22	804	27	-	-	HYPH
cord-023439-r04y1j22	804	28	versus	versus	IN
cord-023439-r04y1j22	804	29	-	-	HYPH
cord-023439-r04y1j22	804	30	tumour	tumour	NN
cord-023439-r04y1j22	804	31	effect	effect	NN
cord-023439-r04y1j22	804	32	remain	remain	VBP
cord-023439-r04y1j22	804	33	largely	largely	RB
cord-023439-r04y1j22	804	34	unknown	unknown	JJ
cord-023439-r04y1j22	804	35	.	.	.
cord-023439-r04y1j22	805	1	In	in	IN
cord-023439-r04y1j22	805	2	a	a	DT
cord-023439-r04y1j22	805	3	recently	recently	RB
cord-023439-r04y1j22	805	4	initiated	initiate	VBN
cord-023439-r04y1j22	805	5	project	project	NN
cord-023439-r04y1j22	805	6	,	,	,
cord-023439-r04y1j22	805	7	we	-PRON-	PRP
cord-023439-r04y1j22	805	8	have	have	VBP
cord-023439-r04y1j22	805	9	conducted	conduct	VBN
cord-023439-r04y1j22	805	10	a	a	DT
cord-023439-r04y1j22	805	11	longitudinal	longitudinal	JJ
cord-023439-r04y1j22	805	12	study	study	NN
cord-023439-r04y1j22	805	13	of	of	IN
cord-023439-r04y1j22	805	14	T	t	NN
cord-023439-r04y1j22	805	15	-	-	HYPH
cord-023439-r04y1j22	805	16	cell	cell	NN
cord-023439-r04y1j22	805	17	clonotypes	clonotype	NNS
cord-023439-r04y1j22	805	18	in	in	IN
cord-023439-r04y1j22	805	19	patients	patient	NNS
cord-023439-r04y1j22	805	20	who	who	WP
cord-023439-r04y1j22	805	21	received	receive	VBD
cord-023439-r04y1j22	805	22	peripheral	peripheral	JJ
cord-023439-r04y1j22	805	23	blood	blood	NN
cord-023439-r04y1j22	805	24	stem	stem	NN
cord-023439-r04y1j22	805	25	cell	cell	NN
cord-023439-r04y1j22	805	26	grafts	graft	NNS
cord-023439-r04y1j22	805	27	after	after	IN
cord-023439-r04y1j22	805	28	nonmyeloablative	nonmyeloablative	JJ
cord-023439-r04y1j22	805	29	conditioning	conditioning	NN
cord-023439-r04y1j22	805	30	.	.	.
cord-023439-r04y1j22	806	1	Peripheral	peripheral	JJ
cord-023439-r04y1j22	806	2	blood	blood	NN
cord-023439-r04y1j22	806	3	samples	sample	NNS
cord-023439-r04y1j22	806	4	were	be	VBD
cord-023439-r04y1j22	806	5	obtained	obtain	VBN
cord-023439-r04y1j22	806	6	sequentially	sequentially	RB
cord-023439-r04y1j22	806	7	after	after	IN
cord-023439-r04y1j22	806	8	transplant	transplant	NN
cord-023439-r04y1j22	806	9	,	,	,
cord-023439-r04y1j22	806	10	and	and	CC
cord-023439-r04y1j22	806	11	the	the	DT
cord-023439-r04y1j22	806	12	mononuclear	mononuclear	NN
cord-023439-r04y1j22	806	13	cells	cell	NNS
cord-023439-r04y1j22	806	14	(	(	-LRB-
cord-023439-r04y1j22	806	15	MNCs	mnc	NNS
cord-023439-r04y1j22	806	16	)	)	-RRB-
cord-023439-r04y1j22	806	17	were	be	VBD
cord-023439-r04y1j22	806	18	isolated	isolate	VBN
cord-023439-r04y1j22	806	19	and	and	CC
cord-023439-r04y1j22	806	20	cryopreserved	cryopreserve	VBN
cord-023439-r04y1j22	806	21	.	.	.
cord-023439-r04y1j22	807	1	CD8	CD8	NNP
cord-023439-r04y1j22	807	2	þ	þ	NNP
cord-023439-r04y1j22	807	3	T	T	NNP
cord-023439-r04y1j22	807	4	cells	cell	NNS
cord-023439-r04y1j22	807	5	were	be	VBD
cord-023439-r04y1j22	807	6	isolated	isolate	VBN
cord-023439-r04y1j22	807	7	from	from	IN
cord-023439-r04y1j22	807	8	the	the	DT
cord-023439-r04y1j22	807	9	MNCs	mnc	NNS
cord-023439-r04y1j22	807	10	by	by	IN
cord-023439-r04y1j22	807	11	use	use	NN
cord-023439-r04y1j22	807	12	of	of	IN
cord-023439-r04y1j22	807	13	immunomagnetic	immunomagnetic	JJ
cord-023439-r04y1j22	807	14	beads	bead	NNS
cord-023439-r04y1j22	807	15	or	or	CC
cord-023439-r04y1j22	807	16	FACS	FACS	NNP
cord-023439-r04y1j22	807	17	and	and	CC
cord-023439-r04y1j22	807	18	analysed	analyse	VBD
cord-023439-r04y1j22	807	19	for	for	IN
cord-023439-r04y1j22	807	20	the	the	DT
cord-023439-r04y1j22	807	21	presence	presence	NN
cord-023439-r04y1j22	807	22	of	of	IN
cord-023439-r04y1j22	807	23	clonally	clonally	RB
cord-023439-r04y1j22	807	24	expanded	expand	VBN
cord-023439-r04y1j22	807	25	cells	cell	NNS
cord-023439-r04y1j22	807	26	by	by	IN
cord-023439-r04y1j22	807	27	T	t	NN
cord-023439-r04y1j22	807	28	-	-	HYPH
cord-023439-r04y1j22	807	29	cell	cell	NN
cord-023439-r04y1j22	807	30	receptor	receptor	NN
cord-023439-r04y1j22	807	31	clonotype	clonotype	NN
cord-023439-r04y1j22	807	32	mapping	mapping	NN
cord-023439-r04y1j22	807	33	based	base	VBN
cord-023439-r04y1j22	807	34	on	on	IN
cord-023439-r04y1j22	807	35	RT	RT	NNP
cord-023439-r04y1j22	807	36	-	-	HYPH
cord-023439-r04y1j22	807	37	PCR	PCR	NNP
cord-023439-r04y1j22	807	38	and	and	CC
cord-023439-r04y1j22	807	39	denaturing	denaturing	JJ
cord-023439-r04y1j22	807	40	gradient	gradient	NN
cord-023439-r04y1j22	807	41	gel	gel	NN
cord-023439-r04y1j22	807	42	electrophoresis	electrophoresis	NN
cord-023439-r04y1j22	807	43	(	(	-LRB-
cord-023439-r04y1j22	807	44	DGGE	DGGE	NNP
cord-023439-r04y1j22	807	45	)	)	-RRB-
cord-023439-r04y1j22	807	46	.	.	.
cord-023439-r04y1j22	808	1	Using	use	VBG
cord-023439-r04y1j22	808	2	this	this	DT
cord-023439-r04y1j22	808	3	gel	gel	NN
cord-023439-r04y1j22	808	4	-	-	HYPH
cord-023439-r04y1j22	808	5	based	base	VBN
cord-023439-r04y1j22	808	6	methodology	methodology	NN
cord-023439-r04y1j22	808	7	,	,	,
cord-023439-r04y1j22	808	8	clonally	clonally	NNP
cord-023439-r04y1j22	808	9	expanded	expand	VBD
cord-023439-r04y1j22	808	10	T	t	NN
cord-023439-r04y1j22	808	11	cells	cell	NNS
cord-023439-r04y1j22	808	12	were	be	VBD
cord-023439-r04y1j22	808	13	monitored	monitor	VBN
cord-023439-r04y1j22	808	14	after	after	IN
cord-023439-r04y1j22	808	15	transplant	transplant	NN
cord-023439-r04y1j22	808	16	and	and	CC
cord-023439-r04y1j22	808	17	compared	compare	VBN
cord-023439-r04y1j22	808	18	to	to	IN
cord-023439-r04y1j22	808	19	the	the	DT
cord-023439-r04y1j22	808	20	clinical	clinical	JJ
cord-023439-r04y1j22	808	21	data	datum	NNS
cord-023439-r04y1j22	808	22	of	of	IN
cord-023439-r04y1j22	808	23	the	the	DT
cord-023439-r04y1j22	808	24	patients	patient	NNS
cord-023439-r04y1j22	808	25	.	.	.
cord-023439-r04y1j22	809	1	The	the	DT
cord-023439-r04y1j22	809	2	preliminary	preliminary	JJ
cord-023439-r04y1j22	809	3	results	result	NNS
cord-023439-r04y1j22	809	4	demonstrates	demonstrate	VBZ
cord-023439-r04y1j22	809	5	the	the	DT
cord-023439-r04y1j22	809	6	presence	presence	NN
cord-023439-r04y1j22	809	7	of	of	IN
cord-023439-r04y1j22	809	8	clonally	clonally	RB
cord-023439-r04y1j22	809	9	expanded	expand	VBN
cord-023439-r04y1j22	809	10	CD8	CD8	NNP
cord-023439-r04y1j22	809	11	þ	þ	NNP
cord-023439-r04y1j22	809	12	T	T	NNP
cord-023439-r04y1j22	809	13	cells	cell	NNS
cord-023439-r04y1j22	809	14	at	at	IN
cord-023439-r04y1j22	809	15	all	all	DT
cord-023439-r04y1j22	809	16	time	time	NN
cord-023439-r04y1j22	809	17	points	point	NNS
cord-023439-r04y1j22	809	18	analysed	analyse	VBN
cord-023439-r04y1j22	809	19	.	.	.
cord-023439-r04y1j22	810	1	Furthermore	furthermore	RB
cord-023439-r04y1j22	810	2	,	,	,
cord-023439-r04y1j22	810	3	a	a	DT
cord-023439-r04y1j22	810	4	number	number	NN
cord-023439-r04y1j22	810	5	of	of	IN
cord-023439-r04y1j22	810	6	clonotypes	clonotype	NNS
cord-023439-r04y1j22	810	7	persisted	persist	VBD
cord-023439-r04y1j22	810	8	for	for	IN
cord-023439-r04y1j22	810	9	more	more	JJR
cord-023439-r04y1j22	810	10	than	than	IN
cord-023439-r04y1j22	810	11	6	6	CD
cord-023439-r04y1j22	810	12	months	month	NNS
cord-023439-r04y1j22	810	13	,	,	,
cord-023439-r04y1j22	810	14	and	and	CC
cord-023439-r04y1j22	810	15	other	other	JJ
cord-023439-r04y1j22	810	16	clonotypes	clonotype	NNS
cord-023439-r04y1j22	810	17	emerged	emerge	VBD
cord-023439-r04y1j22	810	18	during	during	IN
cord-023439-r04y1j22	810	19	this	this	DT
cord-023439-r04y1j22	810	20	period	period	NN
cord-023439-r04y1j22	810	21	.	.	.
cord-023439-r04y1j22	811	1	The	the	DT
cord-023439-r04y1j22	811	2	appearance	appearance	NN
cord-023439-r04y1j22	811	3	of	of	IN
cord-023439-r04y1j22	811	4	newly	newly	RB
cord-023439-r04y1j22	811	5	emerged	emerge	VBN
cord-023439-r04y1j22	811	6	clonotypes	clonotype	NNS
cord-023439-r04y1j22	811	7	which	which	WDT
cord-023439-r04y1j22	811	8	coincided	coincide	VBD
cord-023439-r04y1j22	811	9	with	with	IN
cord-023439-r04y1j22	811	10	clinical	clinical	JJ
cord-023439-r04y1j22	811	11	GVHD	GVHD	NNP
cord-023439-r04y1j22	811	12	could	could	MD
cord-023439-r04y1j22	811	13	indicate	indicate	VB
cord-023439-r04y1j22	811	14	a	a	DT
cord-023439-r04y1j22	811	15	role	role	NN
cord-023439-r04y1j22	811	16	for	for	IN
cord-023439-r04y1j22	811	17	these	these	DT
cord-023439-r04y1j22	811	18	T	t	NN
cord-023439-r04y1j22	811	19	cells	cell	NNS
cord-023439-r04y1j22	811	20	in	in	IN
cord-023439-r04y1j22	811	21	the	the	DT
cord-023439-r04y1j22	811	22	pathogenesis	pathogenesis	NN
cord-023439-r04y1j22	811	23	of	of	IN
cord-023439-r04y1j22	811	24	GVHD	GVHD	NNP
cord-023439-r04y1j22	811	25	.	.	.
cord-023439-r04y1j22	812	1	Background	background	NN
cord-023439-r04y1j22	812	2	:	:	:
cord-023439-r04y1j22	813	1	Deficiency	deficiency	NN
cord-023439-r04y1j22	813	2	of	of	IN
cord-023439-r04y1j22	813	3	the	the	DT
cord-023439-r04y1j22	813	4	mannan	mannan	NN
cord-023439-r04y1j22	813	5	-	-	HYPH
cord-023439-r04y1j22	813	6	binding	bind	VBG
cord-023439-r04y1j22	813	7	lectin	lectin	NN
cord-023439-r04y1j22	813	8	(	(	-LRB-
cord-023439-r04y1j22	813	9	MBL	MBL	NNP
cord-023439-r04y1j22	813	10	)	)	-RRB-
cord-023439-r04y1j22	813	11	pathway	pathway	NN
cord-023439-r04y1j22	813	12	of	of	IN
cord-023439-r04y1j22	813	13	innate	innate	JJ
cord-023439-r04y1j22	813	14	immunity	immunity	NN
cord-023439-r04y1j22	813	15	leads	lead	VBZ
cord-023439-r04y1j22	813	16	to	to	IN
cord-023439-r04y1j22	813	17	increased	increase	VBN
cord-023439-r04y1j22	813	18	susceptibility	susceptibility	NN
cord-023439-r04y1j22	813	19	to	to	IN
cord-023439-r04y1j22	813	20	infections	infection	NNS
cord-023439-r04y1j22	813	21	.	.	.
cord-023439-r04y1j22	814	1	In	in	IN
cord-023439-r04y1j22	814	2	patients	patient	NNS
cord-023439-r04y1j22	814	3	with	with	IN
cord-023439-r04y1j22	814	4	colorectal	colorectal	JJ
cord-023439-r04y1j22	814	5	cancer	cancer	NN
cord-023439-r04y1j22	814	6	,	,	,
cord-023439-r04y1j22	814	7	postoperative	postoperative	JJ
cord-023439-r04y1j22	814	8	infection	infection	NN
cord-023439-r04y1j22	814	9	is	be	VBZ
cord-023439-r04y1j22	814	10	associated	associate	VBN
cord-023439-r04y1j22	814	11	with	with	IN
cord-023439-r04y1j22	814	12	poor	poor	JJ
cord-023439-r04y1j22	814	13	prognosis	prognosis	NN
cord-023439-r04y1j22	814	14	.	.	.
cord-023439-r04y1j22	815	1	The	the	DT
cord-023439-r04y1j22	815	2	aim	aim	NN
cord-023439-r04y1j22	815	3	of	of	IN
cord-023439-r04y1j22	815	4	the	the	DT
cord-023439-r04y1j22	815	5	present	present	JJ
cord-023439-r04y1j22	815	6	study	study	NN
cord-023439-r04y1j22	815	7	was	be	VBD
cord-023439-r04y1j22	815	8	to	to	TO
cord-023439-r04y1j22	815	9	evaluate	evaluate	VB
cord-023439-r04y1j22	815	10	(	(	-LRB-
cord-023439-r04y1j22	815	11	1	1	LS
cord-023439-r04y1j22	815	12	)	)	-RRB-
cord-023439-r04y1j22	815	13	the	the	DT
cord-023439-r04y1j22	815	14	relation	relation	NN
cord-023439-r04y1j22	815	15	between	between	IN
cord-023439-r04y1j22	815	16	the	the	DT
cord-023439-r04y1j22	815	17	MBL	MBL	NNP
cord-023439-r04y1j22	815	18	pathway	pathway	NN
cord-023439-r04y1j22	815	19	and	and	CC
cord-023439-r04y1j22	815	20	postoperative	postoperative	JJ
cord-023439-r04y1j22	815	21	infectious	infectious	JJ
cord-023439-r04y1j22	815	22	complications	complication	NNS
cord-023439-r04y1j22	815	23	and	and	CC
cord-023439-r04y1j22	815	24	survival	survival	NN
cord-023439-r04y1j22	815	25	of	of	IN
cord-023439-r04y1j22	815	26	patients	patient	NNS
cord-023439-r04y1j22	815	27	resected	resect	VBN
cord-023439-r04y1j22	815	28	for	for	IN
cord-023439-r04y1j22	815	29	colorectal	colorectal	JJ
cord-023439-r04y1j22	815	30	cancer	cancer	NN
cord-023439-r04y1j22	815	31	and	and	CC
cord-023439-r04y1j22	815	32	(	(	-LRB-
cord-023439-r04y1j22	815	33	2	2	LS
cord-023439-r04y1j22	815	34	)	)	-RRB-
cord-023439-r04y1j22	815	35	the	the	DT
cord-023439-r04y1j22	815	36	role	role	NN
cord-023439-r04y1j22	815	37	of	of	IN
cord-023439-r04y1j22	815	38	MBL	MBL	NNP
cord-023439-r04y1j22	815	39	as	as	IN
cord-023439-r04y1j22	815	40	acute	acute	JJ
cord-023439-r04y1j22	815	41	phase	phase	NN
cord-023439-r04y1j22	815	42	reactant	reactant	NN
cord-023439-r04y1j22	815	43	compared	compare	VBN
cord-023439-r04y1j22	815	44	to	to	IN
cord-023439-r04y1j22	815	45	CRP	CRP	NNP
cord-023439-r04y1j22	815	46	.	.	.
cord-023439-r04y1j22	816	1	Methods	method	NNS
cord-023439-r04y1j22	816	2	:	:	:
cord-023439-r04y1j22	816	3	Preoperative	Preoperative	NNP
cord-023439-r04y1j22	816	4	MBL	MBL	NNP
cord-023439-r04y1j22	816	5	concentration	concentration	NN
cord-023439-r04y1j22	816	6	,	,	,
cord-023439-r04y1j22	816	7	MBL	MBL	NNP
cord-023439-r04y1j22	816	8	/	/	SYM
cord-023439-r04y1j22	816	9	MBLassociated	mblassociated	JJ
cord-023439-r04y1j22	816	10	serine	serine	NN
cord-023439-r04y1j22	816	11	protease	protease	NN
cord-023439-r04y1j22	816	12	(	(	-LRB-
cord-023439-r04y1j22	816	13	MASP	MASP	NNP
cord-023439-r04y1j22	816	14	)	)	-RRB-
cord-023439-r04y1j22	816	15	activity	activity	NN
cord-023439-r04y1j22	816	16	and	and	CC
cord-023439-r04y1j22	816	17	CRP	CRP	NNP
cord-023439-r04y1j22	816	18	were	be	VBD
cord-023439-r04y1j22	816	19	determined	determine	VBN
cord-023439-r04y1j22	816	20	in	in	IN
cord-023439-r04y1j22	816	21	serum	serum	NN
cord-023439-r04y1j22	816	22	from	from	IN
cord-023439-r04y1j22	816	23	611	611	CD
cord-023439-r04y1j22	816	24	patients	patient	NNS
cord-023439-r04y1j22	816	25	and	and	CC
cord-023439-r04y1j22	816	26	150	150	CD
cord-023439-r04y1j22	816	27	healthy	healthy	JJ
cord-023439-r04y1j22	816	28	controls	control	NNS
cord-023439-r04y1j22	816	29	.	.	.
cord-023439-r04y1j22	817	1	The	the	DT
cord-023439-r04y1j22	817	2	patients	patient	NNS
cord-023439-r04y1j22	817	3	were	be	VBD
cord-023439-r04y1j22	817	4	observed	observe	VBN
cord-023439-r04y1j22	817	5	for	for	IN
cord-023439-r04y1j22	817	6	8	8	CD
cord-023439-r04y1j22	817	7	years	year	NNS
cord-023439-r04y1j22	817	8	.	.	.
cord-023439-r04y1j22	818	1	Postoperative	postoperative	JJ
cord-023439-r04y1j22	818	2	infections	infection	NNS
cord-023439-r04y1j22	818	3	,	,	,
cord-023439-r04y1j22	818	4	recurrence	recurrence	NN
cord-023439-r04y1j22	818	5	and	and	CC
cord-023439-r04y1j22	818	6	survival	survival	NN
cord-023439-r04y1j22	818	7	were	be	VBD
cord-023439-r04y1j22	818	8	recorded	record	VBN
cord-023439-r04y1j22	818	9	.	.	.
cord-023439-r04y1j22	819	1	Results	result	NNS
cord-023439-r04y1j22	819	2	:	:	:
cord-023439-r04y1j22	820	1	The	the	DT
cord-023439-r04y1j22	820	2	MBL	MBL	NNP
cord-023439-r04y1j22	820	3	pathway	pathway	NN
cord-023439-r04y1j22	820	4	components	component	NNS
cord-023439-r04y1j22	820	5	were	be	VBD
cord-023439-r04y1j22	820	6	increased	increase	VBN
cord-023439-r04y1j22	820	7	in	in	IN
cord-023439-r04y1j22	820	8	the	the	DT
cord-023439-r04y1j22	820	9	patients	patient	NNS
cord-023439-r04y1j22	820	10	(	(	-LRB-
cord-023439-r04y1j22	820	11	P	p	NN
cord-023439-r04y1j22	820	12	<	<	XX
cord-023439-r04y1j22	820	13	0.0001	0.0001	CD
cord-023439-r04y1j22	820	14	)	)	-RRB-
cord-023439-r04y1j22	820	15	compared	compare	VBN
cord-023439-r04y1j22	820	16	to	to	IN
cord-023439-r04y1j22	820	17	healthy	healthy	JJ
cord-023439-r04y1j22	820	18	controls	control	NNS
cord-023439-r04y1j22	820	19	.	.	.
cord-023439-r04y1j22	821	1	Low	low	JJ
cord-023439-r04y1j22	821	2	MBL	MBL	NNP
cord-023439-r04y1j22	821	3	levels	level	NNS
cord-023439-r04y1j22	821	4	were	be	VBD
cord-023439-r04y1j22	821	5	predictive	predictive	JJ
cord-023439-r04y1j22	821	6	of	of	IN
cord-023439-r04y1j22	821	7	pneumonia	pneumonia	NN
cord-023439-r04y1j22	821	8	(	(	-LRB-
cord-023439-r04y1j22	821	9	P	p	NN
cord-023439-r04y1j22	821	10	¼	¼	CD
cord-023439-r04y1j22	821	11	0.01	0.01	CD
cord-023439-r04y1j22	821	12	)	)	-RRB-
cord-023439-r04y1j22	821	13	,	,	,
cord-023439-r04y1j22	821	14	and	and	CC
cord-023439-r04y1j22	821	15	pneumonia	pneumonia	NN
cord-023439-r04y1j22	821	16	(	(	-LRB-
cord-023439-r04y1j22	821	17	n	n	NN
cord-023439-r04y1j22	821	18	¼	¼	NNP
cord-023439-r04y1j22	821	19	87	87	CD
cord-023439-r04y1j22	821	20	)	)	-RRB-
cord-023439-r04y1j22	821	21	was	be	VBD
cord-023439-r04y1j22	821	22	associated	associate	VBN
cord-023439-r04y1j22	821	23	with	with	IN
cord-023439-r04y1j22	821	24	poor	poor	JJ
cord-023439-r04y1j22	821	25	survival	survival	NN
cord-023439-r04y1j22	821	26	(	(	-LRB-
cord-023439-r04y1j22	821	27	P	p	NN
cord-023439-r04y1j22	821	28	¼	¼	CD
cord-023439-r04y1j22	821	29	0.003	0.003	CD
cord-023439-r04y1j22	821	30	,	,	,
cord-023439-r04y1j22	821	31	HR	HR	NNP
cord-023439-r04y1j22	821	32	¼	¼	NNP
cord-023439-r04y1j22	821	33	1.5	1.5	CD
cord-023439-r04y1j22	821	34	,	,	,
cord-023439-r04y1j22	821	35	95	95	CD
cord-023439-r04y1j22	821	36	%	%	NN
cord-023439-r04y1j22	821	37	CI	CI	NNP
cord-023439-r04y1j22	821	38	1.1	1.1	CD
cord-023439-r04y1j22	821	39	-	-	SYM
cord-023439-r04y1j22	821	40	1.9	1.9	CD
cord-023439-r04y1j22	821	41	)	)	-RRB-
cord-023439-r04y1j22	821	42	.	.	.
cord-023439-r04y1j22	822	1	MBL	MBL	NNP
cord-023439-r04y1j22	822	2	and	and	CC
cord-023439-r04y1j22	822	3	MBL/	MBL/	NNP
cord-023439-r04y1j22	822	4	MASP	MASP	NNP
cord-023439-r04y1j22	822	5	activity	activity	NN
cord-023439-r04y1j22	822	6	could	could	MD
cord-023439-r04y1j22	822	7	not	not	RB
cord-023439-r04y1j22	822	8	predict	predict	VB
cord-023439-r04y1j22	822	9	postoperative	postoperative	JJ
cord-023439-r04y1j22	822	10	overall	overall	JJ
cord-023439-r04y1j22	822	11	infections	infection	NNS
cord-023439-r04y1j22	822	12	.	.	.
cord-023439-r04y1j22	823	1	MBL	MBL	NNP
cord-023439-r04y1j22	823	2	showed	show	VBD
cord-023439-r04y1j22	823	3	no	no	DT
cord-023439-r04y1j22	823	4	correlation	correlation	NN
cord-023439-r04y1j22	823	5	(	(	-LRB-
cord-023439-r04y1j22	823	6	spearman	spearman	NNP
cord-023439-r04y1j22	823	7	's	's	POS
cord-023439-r04y1j22	823	8	r	r	NNP
cord-023439-r04y1j22	823	9	¼	¼	NNP
cord-023439-r04y1j22	823	10	0.02	0.02	CD
cord-023439-r04y1j22	823	11	,	,	,
cord-023439-r04y1j22	823	12	95	95	CD
cord-023439-r04y1j22	823	13	%	%	NN
cord-023439-r04y1j22	824	1	CI	CI	NNP
cord-023439-r04y1j22	824	2	À0.06	À0.06	NNP
cord-023439-r04y1j22	824	3	-	-	HYPH
cord-023439-r04y1j22	824	4	0.10	0.10	CD
cord-023439-r04y1j22	824	5	)	)	-RRB-
cord-023439-r04y1j22	824	6	with	with	IN
cord-023439-r04y1j22	824	7	CRP	CRP	NNP
cord-023439-r04y1j22	824	8	.	.	.
cord-023439-r04y1j22	825	1	Conclusions	conclusion	NNS
cord-023439-r04y1j22	825	2	:	:	:
cord-023439-r04y1j22	826	1	Low	low	JJ
cord-023439-r04y1j22	826	2	preoperative	preoperative	JJ
cord-023439-r04y1j22	826	3	MBL	MBL	NNP
cord-023439-r04y1j22	826	4	levels	level	NNS
cord-023439-r04y1j22	826	5	are	be	VBP
cord-023439-r04y1j22	826	6	predictive	predictive	JJ
cord-023439-r04y1j22	826	7	of	of	IN
cord-023439-r04y1j22	826	8	pneumonia	pneumonia	NN
cord-023439-r04y1j22	826	9	,	,	,
cord-023439-r04y1j22	826	10	which	which	WDT
cord-023439-r04y1j22	826	11	is	be	VBZ
cord-023439-r04y1j22	826	12	associated	associate	VBN
cord-023439-r04y1j22	826	13	with	with	IN
cord-023439-r04y1j22	826	14	poorer	poor	JJR
cord-023439-r04y1j22	826	15	survival	survival	NN
cord-023439-r04y1j22	826	16	.	.	.
cord-023439-r04y1j22	827	1	MBL	MBL	NNP
cord-023439-r04y1j22	827	2	concentration	concentration	NN
cord-023439-r04y1j22	827	3	and	and	CC
cord-023439-r04y1j22	827	4	MBL	MBL	NNP
cord-023439-r04y1j22	827	5	/	/	SYM
cord-023439-r04y1j22	827	6	MASP	MASP	NNP
cord-023439-r04y1j22	827	7	activity	activity	NN
cord-023439-r04y1j22	827	8	was	be	VBD
cord-023439-r04y1j22	827	9	not	not	RB
cord-023439-r04y1j22	827	10	predictive	predictive	JJ
cord-023439-r04y1j22	827	11	of	of	IN
cord-023439-r04y1j22	827	12	other	other	JJ
cord-023439-r04y1j22	827	13	postoperative	postoperative	JJ
cord-023439-r04y1j22	827	14	infections	infection	NNS
cord-023439-r04y1j22	827	15	or	or	CC
cord-023439-r04y1j22	827	16	long	long	JJ
cord-023439-r04y1j22	827	17	-	-	HYPH
cord-023439-r04y1j22	827	18	term	term	NN
cord-023439-r04y1j22	827	19	prognosis	prognosis	NN
cord-023439-r04y1j22	827	20	.	.	.
cord-023439-r04y1j22	828	1	MBL	MBL	NNP
cord-023439-r04y1j22	828	2	apparently	apparently	RB
cord-023439-r04y1j22	828	3	is	be	VBZ
cord-023439-r04y1j22	828	4	not	not	RB
cord-023439-r04y1j22	828	5	a	a	DT
cord-023439-r04y1j22	828	6	surrogate	surrogate	JJ
cord-023439-r04y1j22	828	7	measure	measure	NN
cord-023439-r04y1j22	828	8	of	of	IN
cord-023439-r04y1j22	828	9	CRP	CRP	NNP
cord-023439-r04y1j22	828	10	.	.	.
cord-023439-r04y1j22	829	1	Department	Department	NNP
cord-023439-r04y1j22	829	2	of	of	IN
cord-023439-r04y1j22	829	3	Surgery	Surgery	NNP
cord-023439-r04y1j22	829	4	,	,	,
cord-023439-r04y1j22	829	5	University	University	NNP
cord-023439-r04y1j22	829	6	Hospital	Hospital	NNP
cord-023439-r04y1j22	829	7	of	of	IN
cord-023439-r04y1j22	829	8	Erlangen	Erlangen	NNP
cord-023439-r04y1j22	829	9	,	,	,
cord-023439-r04y1j22	829	10	Erlangen	Erlangen	NNP
cord-023439-r04y1j22	829	11	,	,	,
cord-023439-r04y1j22	829	12	Germany	Germany	NNP
cord-023439-r04y1j22	829	13	.	.	.
cord-023439-r04y1j22	830	1	E	e	NN
cord-023439-r04y1j22	830	2	-	-	NN
cord-023439-r04y1j22	830	3	mail	mail	NN
cord-023439-r04y1j22	830	4	:	:	:
cord-023439-r04y1j22	830	5	michael.siassi@rzmail.uni-erlangen.de	michael.siassi@rzmail.uni-erlangen.de	NNP
cord-023439-r04y1j22	830	6	Introduction	introduction	NN
cord-023439-r04y1j22	830	7	:	:	:
cord-023439-r04y1j22	831	1	The	the	DT
cord-023439-r04y1j22	831	2	human	human	JJ
cord-023439-r04y1j22	831	3	collectins	collectin	NNS
cord-023439-r04y1j22	831	4	,	,	,
cord-023439-r04y1j22	831	5	mannan	mannan	NN
cord-023439-r04y1j22	831	6	-	-	HYPH
cord-023439-r04y1j22	831	7	binding	bind	VBG
cord-023439-r04y1j22	831	8	lectin	lectin	NN
cord-023439-r04y1j22	831	9	(	(	-LRB-
cord-023439-r04y1j22	831	10	MBL	MBL	NNP
cord-023439-r04y1j22	831	11	)	)	-RRB-
cord-023439-r04y1j22	831	12	,	,	,
cord-023439-r04y1j22	831	13	surfactant	surfactant	NN
cord-023439-r04y1j22	831	14	protein	protein	NN
cord-023439-r04y1j22	831	15	-	-	HYPH
cord-023439-r04y1j22	831	16	A	a	NN
cord-023439-r04y1j22	831	17	(	(	-LRB-
cord-023439-r04y1j22	831	18	SP	SP	NNP
cord-023439-r04y1j22	831	19	-	-	HYPH
cord-023439-r04y1j22	831	20	A	A	NNP
cord-023439-r04y1j22	831	21	)	)	-RRB-
cord-023439-r04y1j22	831	22	and	and	CC
cord-023439-r04y1j22	831	23	surfactantprotein	surfactantprotein	NNP
cord-023439-r04y1j22	831	24	-	-	HYPH
cord-023439-r04y1j22	831	25	D	D	NNP
cord-023439-r04y1j22	831	26	(	(	-LRB-
cord-023439-r04y1j22	831	27	SP	SP	NNP
cord-023439-r04y1j22	831	28	-	-	HYPH
cord-023439-r04y1j22	831	29	D	D	NNP
cord-023439-r04y1j22	831	30	)	)	-RRB-
cord-023439-r04y1j22	831	31	play	play	VBP
cord-023439-r04y1j22	831	32	a	a	DT
cord-023439-r04y1j22	831	33	central	central	JJ
cord-023439-r04y1j22	831	34	role	role	NN
cord-023439-r04y1j22	831	35	in	in	IN
cord-023439-r04y1j22	831	36	the	the	DT
cord-023439-r04y1j22	831	37	innate	innate	JJ
cord-023439-r04y1j22	831	38	immune	immune	JJ
cord-023439-r04y1j22	831	39	system	system	NN
cord-023439-r04y1j22	831	40	.	.	.
cord-023439-r04y1j22	832	1	Immunological	immunological	JJ
cord-023439-r04y1j22	832	2	responses	response	NNS
cord-023439-r04y1j22	832	3	to	to	IN
cord-023439-r04y1j22	832	4	malignant	malignant	JJ
cord-023439-r04y1j22	832	5	transformation	transformation	NN
cord-023439-r04y1j22	832	6	of	of	IN
cord-023439-r04y1j22	832	7	epithelial	epithelial	JJ
cord-023439-r04y1j22	832	8	cells	cell	NNS
cord-023439-r04y1j22	832	9	gained	gain	VBD
cord-023439-r04y1j22	832	10	increasing	increase	VBG
cord-023439-r04y1j22	832	11	interest	interest	NN
cord-023439-r04y1j22	832	12	recently	recently	RB
cord-023439-r04y1j22	832	13	.	.	.
cord-023439-r04y1j22	833	1	A	a	DT
cord-023439-r04y1j22	833	2	former	former	JJ
cord-023439-r04y1j22	833	3	study	study	NN
cord-023439-r04y1j22	833	4	could	could	MD
cord-023439-r04y1j22	833	5	demonstrate	demonstrate	VB
cord-023439-r04y1j22	833	6	binding	binding	NN
cord-023439-r04y1j22	833	7	of	of	IN
cord-023439-r04y1j22	833	8	MBL	mbl	NN
cord-023439-r04y1j22	833	9	to	to	IN
cord-023439-r04y1j22	833	10	certain	certain	JJ
cord-023439-r04y1j22	833	11	colorectal	colorectal	JJ
cord-023439-r04y1j22	833	12	carcinoma	carcinoma	NN
cord-023439-r04y1j22	833	13	(	(	-LRB-
cord-023439-r04y1j22	833	14	CRC	CRC	NNP
cord-023439-r04y1j22	833	15	)	)	-RRB-
cord-023439-r04y1j22	833	16	cell	cell	NN
cord-023439-r04y1j22	833	17	lines	line	NNS
cord-023439-r04y1j22	833	18	in	in	IN
cord-023439-r04y1j22	833	19	vitro	vitro	FW
cord-023439-r04y1j22	833	20	.	.	.
cord-023439-r04y1j22	834	1	We	-PRON-	PRP
cord-023439-r04y1j22	834	2	therefore	therefore	RB
cord-023439-r04y1j22	834	3	examined	examine	VBD
cord-023439-r04y1j22	834	4	the	the	DT
cord-023439-r04y1j22	834	5	expression	expression	NN
cord-023439-r04y1j22	834	6	of	of	IN
cord-023439-r04y1j22	834	7	human	human	JJ
cord-023439-r04y1j22	834	8	collectins	collectin	NNS
cord-023439-r04y1j22	834	9	in	in	IN
cord-023439-r04y1j22	834	10	normal	normal	JJ
cord-023439-r04y1j22	834	11	colon	colon	NN
cord-023439-r04y1j22	834	12	mucosa	mucosa	NN
cord-023439-r04y1j22	834	13	and	and	CC
cord-023439-r04y1j22	834	14	in	in	IN
cord-023439-r04y1j22	834	15	colorectal	colorectal	JJ
cord-023439-r04y1j22	834	16	carcinomas	carcinoma	NNS
cord-023439-r04y1j22	834	17	.	.	.
cord-023439-r04y1j22	835	1	Materials	material	NNS
cord-023439-r04y1j22	835	2	and	and	CC
cord-023439-r04y1j22	835	3	methods	method	NNS
cord-023439-r04y1j22	835	4	:	:	:
cord-023439-r04y1j22	835	5	Colon	colon	NN
cord-023439-r04y1j22	835	6	samples	sample	NNS
cord-023439-r04y1j22	835	7	from	from	IN
cord-023439-r04y1j22	835	8	20	20	CD
cord-023439-r04y1j22	835	9	CRC	CRC	NNP
cord-023439-r04y1j22	835	10	patients	patient	NNS
cord-023439-r04y1j22	835	11	and	and	CC
cord-023439-r04y1j22	835	12	10	10	CD
cord-023439-r04y1j22	835	13	normal	normal	JJ
cord-023439-r04y1j22	835	14	mucosa	mucosa	JJ
cord-023439-r04y1j22	835	15	samples	sample	NNS
cord-023439-r04y1j22	835	16	were	be	VBD
cord-023439-r04y1j22	835	17	collected	collect	VBN
cord-023439-r04y1j22	835	18	immediately	immediately	RB
cord-023439-r04y1j22	835	19	after	after	IN
cord-023439-r04y1j22	835	20	surgery	surgery	NN
cord-023439-r04y1j22	835	21	.	.	.
cord-023439-r04y1j22	836	1	The	the	DT
cord-023439-r04y1j22	836	2	tissue	tissue	NN
cord-023439-r04y1j22	836	3	was	be	VBD
cord-023439-r04y1j22	836	4	microdissected	microdissecte	VBN
cord-023439-r04y1j22	836	5	and	and	CC
cord-023439-r04y1j22	836	6	RNA	RNA	NNP
cord-023439-r04y1j22	836	7	isolated	isolate	VBD
cord-023439-r04y1j22	836	8	(	(	-LRB-
cord-023439-r04y1j22	836	9	Qiagen	Qiagen	NNP
cord-023439-r04y1j22	836	10	,	,	,
cord-023439-r04y1j22	836	11	Rneasy	Rneasy	NNP
cord-023439-r04y1j22	836	12	-	-	HYPH
cord-023439-r04y1j22	836	13	Kit	Kit	NNP
cord-023439-r04y1j22	836	14	)	)	-RRB-
cord-023439-r04y1j22	836	15	.	.	.
cord-023439-r04y1j22	837	1	Gene	gene	NN
cord-023439-r04y1j22	837	2	expression	expression	NN
cord-023439-r04y1j22	837	3	profiles	profile	NNS
cord-023439-r04y1j22	837	4	were	be	VBD
cord-023439-r04y1j22	837	5	analysed	analyse	VBN
cord-023439-r04y1j22	837	6	using	use	VBG
cord-023439-r04y1j22	837	7	Gene	gene	NN
cord-023439-r04y1j22	837	8	-	-	HYPH
cord-023439-r04y1j22	837	9	chips	chip	NNS
cord-023439-r04y1j22	837	10	(	(	-LRB-
cord-023439-r04y1j22	837	11	Affymetrix	Affymetrix	NNP
cord-023439-r04y1j22	837	12	,	,	,
cord-023439-r04y1j22	837	13	HG	HG	NNP
cord-023439-r04y1j22	837	14	-	-	HYPH
cord-023439-r04y1j22	837	15	U133	U133	NNP
cord-023439-r04y1j22	837	16	)	)	-RRB-
cord-023439-r04y1j22	837	17	.	.	.
cord-023439-r04y1j22	838	1	We	-PRON-	PRP
cord-023439-r04y1j22	838	2	analysed	analyse	VBD
cord-023439-r04y1j22	838	3	the	the	DT
cord-023439-r04y1j22	838	4	data	datum	NNS
cord-023439-r04y1j22	838	5	for	for	IN
cord-023439-r04y1j22	838	6	the	the	DT
cord-023439-r04y1j22	838	7	expression	expression	NN
cord-023439-r04y1j22	838	8	of	of	IN
cord-023439-r04y1j22	838	9	MBL	MBL	NNP
cord-023439-r04y1j22	838	10	,	,	,
cord-023439-r04y1j22	838	11	its	-PRON-	PRP$
cord-023439-r04y1j22	838	12	associated	associated	JJ
cord-023439-r04y1j22	838	13	serine	serine	NN
cord-023439-r04y1j22	838	14	proteases	protease	NNS
cord-023439-r04y1j22	838	15	mannan	mannan	NN
cord-023439-r04y1j22	838	16	-	-	HYPH
cord-023439-r04y1j22	838	17	binding	bind	VBG
cord-023439-r04y1j22	838	18	lectinassociated	lectinassociated	JJ
cord-023439-r04y1j22	838	19	serine	serine	NN
cord-023439-r04y1j22	838	20	protease	protease	NN
cord-023439-r04y1j22	838	21	1/2	1/2	CD
cord-023439-r04y1j22	838	22	(	(	-LRB-
cord-023439-r04y1j22	838	23	MASP	MASP	NNP
cord-023439-r04y1j22	838	24	1/2	1/2	CD
cord-023439-r04y1j22	838	25	)	)	-RRB-
cord-023439-r04y1j22	838	26	,	,	,
cord-023439-r04y1j22	838	27	SP	SP	NNP
cord-023439-r04y1j22	838	28	-	-	HYPH
cord-023439-r04y1j22	838	29	A	A	NNP
cord-023439-r04y1j22	838	30	and	and	CC
cord-023439-r04y1j22	838	31	SP	SP	NNP
cord-023439-r04y1j22	838	32	-	-	HYPH
cord-023439-r04y1j22	838	33	D.	D.	NNP
cord-023439-r04y1j22	839	1	The	the	DT
cord-023439-r04y1j22	839	2	signal	signal	JJ
cord-023439-r04y1j22	839	3	intensity	intensity	NN
cord-023439-r04y1j22	839	4	of	of	IN
cord-023439-r04y1j22	839	5	the	the	DT
cord-023439-r04y1j22	839	6	genes	gene	NNS
cord-023439-r04y1j22	839	7	of	of	IN
cord-023439-r04y1j22	839	8	interest	interest	NN
cord-023439-r04y1j22	839	9	was	be	VBD
cord-023439-r04y1j22	839	10	compared	compare	VBN
cord-023439-r04y1j22	839	11	using	use	VBG
cord-023439-r04y1j22	839	12	the	the	DT
cord-023439-r04y1j22	839	13	Mann	Mann	NNP
cord-023439-r04y1j22	839	14	-	-	HYPH
cord-023439-r04y1j22	839	15	Whitney	Whitney	NNP
cord-023439-r04y1j22	839	16	U	U	NNP
cord-023439-r04y1j22	839	17	-	-	HYPH
cord-023439-r04y1j22	839	18	test	test	NN
cord-023439-r04y1j22	839	19	.	.	.
cord-023439-r04y1j22	840	1	Results	result	NNS
cord-023439-r04y1j22	840	2	:	:	:
cord-023439-r04y1j22	841	1	The	the	DT
cord-023439-r04y1j22	841	2	expression	expression	NN
cord-023439-r04y1j22	841	3	of	of	IN
cord-023439-r04y1j22	841	4	human	human	JJ
cord-023439-r04y1j22	841	5	collectins	collectin	NNS
cord-023439-r04y1j22	841	6	in	in	IN
cord-023439-r04y1j22	841	7	normal	normal	JJ
cord-023439-r04y1j22	841	8	human	human	JJ
cord-023439-r04y1j22	841	9	colon	colon	NN
cord-023439-r04y1j22	841	10	mucosa	mucosa	NN
cord-023439-r04y1j22	841	11	was	be	VBD
cord-023439-r04y1j22	841	12	generally	generally	RB
cord-023439-r04y1j22	841	13	low	low	JJ
cord-023439-r04y1j22	841	14	.	.	.
cord-023439-r04y1j22	842	1	Only	only	RB
cord-023439-r04y1j22	842	2	the	the	DT
cord-023439-r04y1j22	842	3	expression	expression	NN
cord-023439-r04y1j22	842	4	of	of	IN
cord-023439-r04y1j22	842	5	SP	SP	NNP
cord-023439-r04y1j22	842	6	-	-	HYPH
cord-023439-r04y1j22	842	7	A	A	NNP
cord-023439-r04y1j22	842	8	and	and	CC
cord-023439-r04y1j22	842	9	MASP-2	MASP-2	NNP
cord-023439-r04y1j22	842	10	reached	reach	VBD
cord-023439-r04y1j22	842	11	the	the	DT
cord-023439-r04y1j22	842	12	noise	noise	NN
cord-023439-r04y1j22	842	13	threshold	threshold	NN
cord-023439-r04y1j22	842	14	of	of	IN
cord-023439-r04y1j22	842	15	250	250	CD
cord-023439-r04y1j22	842	16	signals	signal	NNS
cord-023439-r04y1j22	842	17	.	.	.
cord-023439-r04y1j22	843	1	These	these	DT
cord-023439-r04y1j22	843	2	genes	gene	NNS
cord-023439-r04y1j22	843	3	were	be	VBD
cord-023439-r04y1j22	843	4	significantly	significantly	RB
cord-023439-r04y1j22	843	5	downregulated	downregulate	VBN
cord-023439-r04y1j22	843	6	in	in	IN
cord-023439-r04y1j22	843	7	CRC	CRC	NNP
cord-023439-r04y1j22	843	8	specimens	specimen	NNS
cord-023439-r04y1j22	843	9	.	.	.
cord-023439-r04y1j22	844	1	The	the	DT
cord-023439-r04y1j22	844	2	expression	expression	NN
cord-023439-r04y1j22	844	3	of	of	IN
cord-023439-r04y1j22	844	4	the	the	DT
cord-023439-r04y1j22	844	5	other	other	JJ
cord-023439-r04y1j22	844	6	proteins	protein	NNS
cord-023439-r04y1j22	844	7	showed	show	VBD
cord-023439-r04y1j22	844	8	no	no	DT
cord-023439-r04y1j22	844	9	difference	difference	NN
cord-023439-r04y1j22	844	10	in	in	IN
cord-023439-r04y1j22	844	11	normal	normal	JJ
cord-023439-r04y1j22	844	12	mucosa	mucosa	NN
cord-023439-r04y1j22	844	13	and	and	CC
cord-023439-r04y1j22	844	14	CRC	CRC	NNP
cord-023439-r04y1j22	844	15	.	.	.
cord-023439-r04y1j22	845	1	Conclusion	conclusion	NN
cord-023439-r04y1j22	845	2	:	:	:
cord-023439-r04y1j22	846	1	As	as	IN
cord-023439-r04y1j22	846	2	demonstrated	demonstrate	VBN
cord-023439-r04y1j22	846	3	before	before	RB
cord-023439-r04y1j22	846	4	,	,	,
cord-023439-r04y1j22	846	5	the	the	DT
cord-023439-r04y1j22	846	6	expression	expression	NN
cord-023439-r04y1j22	846	7	of	of	IN
cord-023439-r04y1j22	846	8	human	human	JJ
cord-023439-r04y1j22	846	9	collectins	collectin	NNS
cord-023439-r04y1j22	846	10	in	in	IN
cord-023439-r04y1j22	846	11	normal	normal	JJ
cord-023439-r04y1j22	846	12	colon	colon	NN
cord-023439-r04y1j22	846	13	was	be	VBD
cord-023439-r04y1j22	846	14	low	low	JJ
cord-023439-r04y1j22	846	15	in	in	IN
cord-023439-r04y1j22	846	16	this	this	DT
cord-023439-r04y1j22	846	17	Being	be	VBG
cord-023439-r04y1j22	846	18	the	the	DT
cord-023439-r04y1j22	846	19	first	first	JJ
cord-023439-r04y1j22	846	20	lymph	lymph	NN
cord-023439-r04y1j22	846	21	node	node	NN
cord-023439-r04y1j22	846	22	to	to	TO
cord-023439-r04y1j22	846	23	receive	receive	VB
cord-023439-r04y1j22	846	24	drainage	drainage	NN
cord-023439-r04y1j22	846	25	from	from	IN
cord-023439-r04y1j22	846	26	the	the	DT
cord-023439-r04y1j22	846	27	tumour	tumour	NN
cord-023439-r04y1j22	846	28	area	area	NN
cord-023439-r04y1j22	846	29	,	,	,
cord-023439-r04y1j22	846	30	the	the	DT
cord-023439-r04y1j22	846	31	sentinel	sentinel	NN
cord-023439-r04y1j22	846	32	node	node	NN
cord-023439-r04y1j22	846	33	offers	offer	VBZ
cord-023439-r04y1j22	846	34	a	a	DT
cord-023439-r04y1j22	846	35	unique	unique	JJ
cord-023439-r04y1j22	846	36	possibility	possibility	NN
cord-023439-r04y1j22	846	37	to	to	TO
cord-023439-r04y1j22	846	38	obtain	obtain	VB
cord-023439-r04y1j22	846	39	tumour	tumour	NN
cord-023439-r04y1j22	846	40	-	-	HYPH
cord-023439-r04y1j22	846	41	reactive	reactive	JJ
cord-023439-r04y1j22	846	42	lymphocytes	lymphocyte	NNS
cord-023439-r04y1j22	846	43	.	.	.
cord-023439-r04y1j22	847	1	We	-PRON-	PRP
cord-023439-r04y1j22	847	2	investigated	investigate	VBD
cord-023439-r04y1j22	847	3	antitumour	antitumour	JJ
cord-023439-r04y1j22	847	4	immune	immune	JJ
cord-023439-r04y1j22	847	5	responses	response	NNS
cord-023439-r04y1j22	847	6	in	in	IN
cord-023439-r04y1j22	847	7	sentinel	sentinel	JJ
cord-023439-r04y1j22	847	8	nodes	node	NNS
cord-023439-r04y1j22	847	9	from	from	IN
cord-023439-r04y1j22	847	10	patients	patient	NNS
cord-023439-r04y1j22	847	11	with	with	IN
cord-023439-r04y1j22	847	12	bladder	bladder	NN
cord-023439-r04y1j22	847	13	cancer	cancer	NN
cord-023439-r04y1j22	847	14	,	,	,
cord-023439-r04y1j22	847	15	by	by	IN
cord-023439-r04y1j22	847	16	assaying	assay	VBG
cord-023439-r04y1j22	847	17	tumour	tumour	NN
cord-023439-r04y1j22	847	18	-	-	HYPH
cord-023439-r04y1j22	847	19	specific	specific	JJ
cord-023439-r04y1j22	847	20	proliferation	proliferation	NN
cord-023439-r04y1j22	847	21	and	and	CC
cord-023439-r04y1j22	847	22	TCR	TCR	NNP
cord-023439-r04y1j22	847	23	Vb	Vb	NNP
cord-023439-r04y1j22	847	24	repertoires	repertoire	NNS
cord-023439-r04y1j22	847	25	.	.	.
cord-023439-r04y1j22	848	1	During	during	IN
cord-023439-r04y1j22	848	2	tumour	tumour	NN
cord-023439-r04y1j22	848	3	surgery	surgery	NN
cord-023439-r04y1j22	848	4	,	,	,
cord-023439-r04y1j22	848	5	sentinel	sentinel	JJ
cord-023439-r04y1j22	848	6	lymph	lymph	NN
cord-023439-r04y1j22	848	7	nodes	node	NNS
cord-023439-r04y1j22	848	8	were	be	VBD
cord-023439-r04y1j22	848	9	identified	identify	VBN
cord-023439-r04y1j22	848	10	by	by	IN
cord-023439-r04y1j22	848	11	peritumoural	peritumoural	JJ
cord-023439-r04y1j22	848	12	injection	injection	NN
cord-023439-r04y1j22	848	13	of	of	IN
cord-023439-r04y1j22	848	14	blue	blue	JJ
cord-023439-r04y1j22	848	15	dye	dye	NN
cord-023439-r04y1j22	848	16	.	.	.
cord-023439-r04y1j22	849	1	Fresh	fresh	JJ
cord-023439-r04y1j22	849	2	specimens	specimen	NNS
cord-023439-r04y1j22	849	3	of	of	IN
cord-023439-r04y1j22	849	4	tumour	tumour	NN
cord-023439-r04y1j22	849	5	,	,	,
cord-023439-r04y1j22	849	6	sentinel	sentinel	NN
cord-023439-r04y1j22	849	7	and	and	CC
cord-023439-r04y1j22	849	8	nonsentinel	nonsentinel	JJ
cord-023439-r04y1j22	849	9	lymph	lymph	NN
cord-023439-r04y1j22	849	10	nodes	node	NNS
cord-023439-r04y1j22	849	11	were	be	VBD
cord-023439-r04y1j22	849	12	obtained	obtain	VBN
cord-023439-r04y1j22	849	13	,	,	,
cord-023439-r04y1j22	849	14	and	and	CC
cord-023439-r04y1j22	849	15	single	single	JJ
cord-023439-r04y1j22	849	16	-	-	HYPH
cord-023439-r04y1j22	849	17	cell	cell	NN
cord-023439-r04y1j22	849	18	suspensions	suspension	NNS
cord-023439-r04y1j22	849	19	were	be	VBD
cord-023439-r04y1j22	849	20	prepared	prepare	VBN
cord-023439-r04y1j22	849	21	.	.	.
cord-023439-r04y1j22	850	1	Cells	cell	NNS
cord-023439-r04y1j22	850	2	were	be	VBD
cord-023439-r04y1j22	850	3	assayed	assay	VBN
cord-023439-r04y1j22	850	4	for	for	IN
cord-023439-r04y1j22	850	5	reactivity	reactivity	NN
cord-023439-r04y1j22	850	6	against	against	IN
cord-023439-r04y1j22	850	7	autologous	autologous	JJ
cord-023439-r04y1j22	850	8	tumour	tumour	NN
cord-023439-r04y1j22	850	9	extract	extract	NN
cord-023439-r04y1j22	850	10	in	in	IN
cord-023439-r04y1j22	850	11	[	[	-LRB-
cord-023439-r04y1j22	850	12	3	3	CD
cord-023439-r04y1j22	850	13	H]-thymidine	H]-thymidine	NNP
cord-023439-r04y1j22	850	14	incorporation	incorporation	NN
cord-023439-r04y1j22	850	15	assays	assay	NNS
cord-023439-r04y1j22	850	16	and	and	CC
cord-023439-r04y1j22	850	17	characterized	characterize	VBN
cord-023439-r04y1j22	850	18	by	by	IN
cord-023439-r04y1j22	850	19	flow	flow	NN
cord-023439-r04y1j22	850	20	cytometry	cytometry	NN
cord-023439-r04y1j22	850	21	.	.	.
cord-023439-r04y1j22	851	1	Parallel	parallel	JJ
cord-023439-r04y1j22	851	2	analyses	analysis	NNS
cord-023439-r04y1j22	851	3	of	of	IN
cord-023439-r04y1j22	851	4	the	the	DT
cord-023439-r04y1j22	851	5	expression	expression	NN
cord-023439-r04y1j22	851	6	of	of	IN
cord-023439-r04y1j22	851	7	Vb	Vb	NNP
cord-023439-r04y1j22	851	8	gene	gene	NN
cord-023439-r04y1j22	851	9	families	family	NNS
cord-023439-r04y1j22	851	10	were	be	VBD
cord-023439-r04y1j22	851	11	performed	perform	VBN
cord-023439-r04y1j22	851	12	with	with	IN
cord-023439-r04y1j22	851	13	padlock	padlock	NN
cord-023439-r04y1j22	851	14	probes	probe	NNS
cord-023439-r04y1j22	851	15	,	,	,
cord-023439-r04y1j22	851	16	linear	linear	JJ
cord-023439-r04y1j22	851	17	oligonucleotides	oligonucleotide	NNS
cord-023439-r04y1j22	851	18	which	which	WDT
cord-023439-r04y1j22	851	19	upon	upon	IN
cord-023439-r04y1j22	851	20	target	target	NN
cord-023439-r04y1j22	851	21	recognition	recognition	NN
cord-023439-r04y1j22	851	22	can	can	MD
cord-023439-r04y1j22	851	23	be	be	VB
cord-023439-r04y1j22	851	24	converted	convert	VBN
cord-023439-r04y1j22	851	25	to	to	IN
cord-023439-r04y1j22	851	26	circular	circular	JJ
cord-023439-r04y1j22	851	27	molecules	molecule	NNS
cord-023439-r04y1j22	851	28	by	by	IN
cord-023439-r04y1j22	851	29	a	a	DT
cord-023439-r04y1j22	851	30	ligase	ligase	NN
cord-023439-r04y1j22	851	31	.	.	.
cord-023439-r04y1j22	852	1	Probes	probe	NNS
cord-023439-r04y1j22	852	2	were	be	VBD
cord-023439-r04y1j22	852	3	reacted	react	VBN
cord-023439-r04y1j22	852	4	with	with	IN
cord-023439-r04y1j22	852	5	cDNA	cdna	NN
cord-023439-r04y1j22	852	6	prepared	prepare	VBN
cord-023439-r04y1j22	852	7	from	from	IN
cord-023439-r04y1j22	852	8	magnetically	magnetically	RB
cord-023439-r04y1j22	852	9	separated	separate	VBN
cord-023439-r04y1j22	852	10	CD4	CD4	NNP
cord-023439-r04y1j22	852	11	þ	þ	NNP
cord-023439-r04y1j22	852	12	cells	cell	NNS
cord-023439-r04y1j22	852	13	,	,	,
cord-023439-r04y1j22	852	14	and	and	CC
cord-023439-r04y1j22	852	15	the	the	DT
cord-023439-r04y1j22	852	16	TCR	TCR	NNP
cord-023439-r04y1j22	852	17	repertoire	repertoire	NN
cord-023439-r04y1j22	852	18	was	be	VBD
cord-023439-r04y1j22	852	19	determined	determine	VBN
cord-023439-r04y1j22	852	20	by	by	IN
cord-023439-r04y1j22	852	21	hybridizing	hybridize	VBG
cord-023439-r04y1j22	852	22	the	the	DT
cord-023439-r04y1j22	852	23	products	product	NNS
cord-023439-r04y1j22	852	24	to	to	IN
cord-023439-r04y1j22	852	25	oligonucleotide	oligonucleotide	JJ
cord-023439-r04y1j22	852	26	microarrays	microarray	NNS
cord-023439-r04y1j22	852	27	.	.	.
cord-023439-r04y1j22	853	1	Dose	dose	NN
cord-023439-r04y1j22	853	2	-	-	HYPH
cord-023439-r04y1j22	853	3	dependent	dependent	JJ
cord-023439-r04y1j22	853	4	proliferation	proliferation	NN
cord-023439-r04y1j22	853	5	in	in	IN
cord-023439-r04y1j22	853	6	response	response	NN
cord-023439-r04y1j22	853	7	to	to	TO
cord-023439-r04y1j22	853	8	tumour	tumour	NN
cord-023439-r04y1j22	853	9	extract	extract	NN
cord-023439-r04y1j22	853	10	could	could	MD
cord-023439-r04y1j22	853	11	be	be	VB
cord-023439-r04y1j22	853	12	detected	detect	VBN
cord-023439-r04y1j22	853	13	in	in	IN
cord-023439-r04y1j22	853	14	sentinel	sentinel	JJ
cord-023439-r04y1j22	853	15	lymph	lymph	NN
cord-023439-r04y1j22	853	16	nodes	node	NNS
cord-023439-r04y1j22	853	17	.	.	.
cord-023439-r04y1j22	854	1	Common	common	JJ
cord-023439-r04y1j22	854	2	clonal	clonal	JJ
cord-023439-r04y1j22	854	3	expansions	expansion	NNS
cord-023439-r04y1j22	854	4	were	be	VBD
cord-023439-r04y1j22	854	5	detected	detect	VBN
cord-023439-r04y1j22	854	6	among	among	IN
cord-023439-r04y1j22	854	7	tumourinfiltrating	tumourinfiltrating	NN
cord-023439-r04y1j22	854	8	lymphocytes	lymphocyte	NNS
cord-023439-r04y1j22	854	9	and	and	CC
cord-023439-r04y1j22	854	10	in	in	IN
cord-023439-r04y1j22	854	11	sentinel	sentinel	JJ
cord-023439-r04y1j22	854	12	lymph	lymph	NN
cord-023439-r04y1j22	854	13	nodes	node	NNS
cord-023439-r04y1j22	854	14	.	.	.
cord-023439-r04y1j22	855	1	Nonsentinel	Nonsentinel	NNP
cord-023439-r04y1j22	855	2	lymph	lymph	NN
cord-023439-r04y1j22	855	3	nodes	node	NNS
cord-023439-r04y1j22	855	4	displayed	display	VBD
cord-023439-r04y1j22	855	5	a	a	DT
cord-023439-r04y1j22	855	6	divergent	divergent	JJ
cord-023439-r04y1j22	855	7	TCR	TCR	NNP
cord-023439-r04y1j22	855	8	Vb	Vb	NNP
cord-023439-r04y1j22	855	9	repertoire	repertoire	NN
cord-023439-r04y1j22	855	10	.	.	.
cord-023439-r04y1j22	856	1	These	these	DT
cord-023439-r04y1j22	856	2	results	result	NNS
cord-023439-r04y1j22	856	3	indicate	indicate	VBP
cord-023439-r04y1j22	856	4	an	an	DT
cord-023439-r04y1j22	856	5	ongoing	ongoing	JJ
cord-023439-r04y1j22	856	6	immune	immune	JJ
cord-023439-r04y1j22	856	7	response	response	NN
cord-023439-r04y1j22	856	8	against	against	IN
cord-023439-r04y1j22	856	9	tumour	tumour	NN
cord-023439-r04y1j22	856	10	antigens	antigen	NNS
cord-023439-r04y1j22	856	11	in	in	IN
cord-023439-r04y1j22	856	12	sentinel	sentinel	JJ
cord-023439-r04y1j22	856	13	nodes	node	NNS
cord-023439-r04y1j22	856	14	,	,	,
cord-023439-r04y1j22	856	15	draining	drain	VBG
cord-023439-r04y1j22	856	16	urinary	urinary	JJ
cord-023439-r04y1j22	856	17	bladder	bladder	NN
cord-023439-r04y1j22	856	18	cancer	cancer	NN
cord-023439-r04y1j22	856	19	.	.	.
cord-023439-r04y1j22	857	1	Identification	identification	NN
cord-023439-r04y1j22	857	2	of	of	IN
cord-023439-r04y1j22	857	3	sentinel	sentinel	JJ
cord-023439-r04y1j22	857	4	lymph	lymph	NN
cord-023439-r04y1j22	857	5	nodes	node	NNS
cord-023439-r04y1j22	857	6	makes	make	VBZ
cord-023439-r04y1j22	857	7	it	-PRON-	PRP
cord-023439-r04y1j22	857	8	possible	possible	JJ
cord-023439-r04y1j22	857	9	to	to	TO
cord-023439-r04y1j22	857	10	obtain	obtain	VB
cord-023439-r04y1j22	857	11	tumour	tumour	NN
cord-023439-r04y1j22	857	12	-	-	HYPH
cord-023439-r04y1j22	857	13	reactive	reactive	JJ
cord-023439-r04y1j22	857	14	lymphocytes	lymphocyte	NNS
cord-023439-r04y1j22	857	15	for	for	IN
cord-023439-r04y1j22	857	16	use	use	NN
cord-023439-r04y1j22	857	17	in	in	IN
cord-023439-r04y1j22	857	18	adoptive	adoptive	JJ
cord-023439-r04y1j22	857	19	immunotherapy	immunotherapy	NN
cord-023439-r04y1j22	857	20	.	.	.