id sid tid token lemma pos cord-252725-e3pazjdi 1 1 key key JJ cord-252725-e3pazjdi 1 2 : : : cord-252725-e3pazjdi 1 3 cord-252725-e3pazjdi cord-252725-e3pazjdi NN cord-252725-e3pazjdi 1 4 authors author NNS cord-252725-e3pazjdi 1 5 : : : cord-252725-e3pazjdi 1 6 Khalil Khalil NNP cord-252725-e3pazjdi 1 7 , , , cord-252725-e3pazjdi 1 8 Ayman Ayman NNP cord-252725-e3pazjdi 1 9 ; ; : cord-252725-e3pazjdi 1 10 Tazeddinova Tazeddinova NNP cord-252725-e3pazjdi 1 11 , , , cord-252725-e3pazjdi 2 1 Diana Diana NNP cord-252725-e3pazjdi 2 2 title title NN cord-252725-e3pazjdi 2 3 : : : cord-252725-e3pazjdi 3 1 The the DT cord-252725-e3pazjdi 3 2 upshot upshot NN cord-252725-e3pazjdi 3 3 of of IN cord-252725-e3pazjdi 3 4 Polyphenolic Polyphenolic NNP cord-252725-e3pazjdi 3 5 compounds compound NNS cord-252725-e3pazjdi 3 6 on on IN cord-252725-e3pazjdi 3 7 immunity immunity NN cord-252725-e3pazjdi 3 8 amid amid IN cord-252725-e3pazjdi 3 9 COVID-19 covid-19 CD cord-252725-e3pazjdi 3 10 pandemic pandemic NN cord-252725-e3pazjdi 3 11 and and CC cord-252725-e3pazjdi 3 12 other other JJ cord-252725-e3pazjdi 3 13 emerging emerge VBG cord-252725-e3pazjdi 3 14 communicable communicable JJ cord-252725-e3pazjdi 3 15 diseases disease NNS cord-252725-e3pazjdi 3 16 : : : cord-252725-e3pazjdi 3 17 An an DT cord-252725-e3pazjdi 3 18 appraisal appraisal NN cord-252725-e3pazjdi 3 19 date date NN cord-252725-e3pazjdi 3 20 : : : cord-252725-e3pazjdi 3 21 2020 2020 CD cord-252725-e3pazjdi 3 22 - - SYM cord-252725-e3pazjdi 3 23 10 10 CD cord-252725-e3pazjdi 3 24 - - SYM cord-252725-e3pazjdi 3 25 15 15 CD cord-252725-e3pazjdi 3 26 journal journal NN cord-252725-e3pazjdi 3 27 : : : cord-252725-e3pazjdi 4 1 Nat Nat NNP cord-252725-e3pazjdi 4 2 Prod Prod NNP cord-252725-e3pazjdi 4 3 Bioprospect Bioprospect NNP cord-252725-e3pazjdi 4 4 DOI DOI NNP cord-252725-e3pazjdi 4 5 : : : cord-252725-e3pazjdi 5 1 10.1007 10.1007 CD cord-252725-e3pazjdi 5 2 / / SYM cord-252725-e3pazjdi 5 3 s13659 s13659 NNP cord-252725-e3pazjdi 5 4 - - HYPH cord-252725-e3pazjdi 5 5 020 020 CD cord-252725-e3pazjdi 5 6 - - HYPH cord-252725-e3pazjdi 5 7 00271-z 00271-z CD cord-252725-e3pazjdi 5 8 sha sha NNP cord-252725-e3pazjdi 5 9 : : : cord-252725-e3pazjdi 6 1 6601e2e7f3de51e1e646d10a40b4fc38e904615b 6601e2e7f3de51e1e646d10a40b4fc38e904615b LS cord-252725-e3pazjdi 6 2 doc_id doc_id CD cord-252725-e3pazjdi 7 1 : : : cord-252725-e3pazjdi 7 2 252725 252725 CD cord-252725-e3pazjdi 7 3 cord_uid cord_uid NNS cord-252725-e3pazjdi 7 4 : : : cord-252725-e3pazjdi 8 1 e3pazjdi e3pazjdi NNP cord-252725-e3pazjdi 8 2 Polyphenols Polyphenols NNP cord-252725-e3pazjdi 8 3 are be VBP cord-252725-e3pazjdi 8 4 a a DT cord-252725-e3pazjdi 8 5 large large JJ cord-252725-e3pazjdi 8 6 family family NN cord-252725-e3pazjdi 8 7 of of IN cord-252725-e3pazjdi 8 8 more more JJR cord-252725-e3pazjdi 8 9 than than IN cord-252725-e3pazjdi 8 10 10,000 10,000 CD cord-252725-e3pazjdi 8 11 naturally naturally RB cord-252725-e3pazjdi 8 12 occurring occur VBG cord-252725-e3pazjdi 8 13 compounds compound NNS cord-252725-e3pazjdi 8 14 , , , cord-252725-e3pazjdi 8 15 which which WDT cord-252725-e3pazjdi 8 16 exert exert VBP cord-252725-e3pazjdi 8 17 countless countless JJ cord-252725-e3pazjdi 8 18 pharmacological pharmacological JJ cord-252725-e3pazjdi 8 19 , , , cord-252725-e3pazjdi 8 20 biological biological JJ cord-252725-e3pazjdi 8 21 and and CC cord-252725-e3pazjdi 8 22 physiological physiological JJ cord-252725-e3pazjdi 8 23 benefits benefit NNS cord-252725-e3pazjdi 8 24 for for IN cord-252725-e3pazjdi 8 25 human human JJ cord-252725-e3pazjdi 8 26 health health NN cord-252725-e3pazjdi 8 27 including include VBG cord-252725-e3pazjdi 8 28 several several JJ cord-252725-e3pazjdi 8 29 chronic chronic JJ cord-252725-e3pazjdi 8 30 diseases disease NNS cord-252725-e3pazjdi 8 31 such such JJ cord-252725-e3pazjdi 8 32 as as IN cord-252725-e3pazjdi 8 33 cancer cancer NN cord-252725-e3pazjdi 8 34 , , , cord-252725-e3pazjdi 8 35 diabetes diabetes NN cord-252725-e3pazjdi 8 36 , , , cord-252725-e3pazjdi 8 37 cardiovascular cardiovascular JJ cord-252725-e3pazjdi 8 38 , , , cord-252725-e3pazjdi 8 39 and and CC cord-252725-e3pazjdi 8 40 neurological neurological JJ cord-252725-e3pazjdi 8 41 diseases disease NNS cord-252725-e3pazjdi 8 42 . . . cord-252725-e3pazjdi 9 1 Their -PRON- PRP$ cord-252725-e3pazjdi 9 2 role role NN cord-252725-e3pazjdi 9 3 in in IN cord-252725-e3pazjdi 9 4 traditional traditional JJ cord-252725-e3pazjdi 9 5 medicine medicine NN cord-252725-e3pazjdi 9 6 , , , cord-252725-e3pazjdi 9 7 such such JJ cord-252725-e3pazjdi 9 8 as as IN cord-252725-e3pazjdi 9 9 the the DT cord-252725-e3pazjdi 9 10 use use NN cord-252725-e3pazjdi 9 11 of of IN cord-252725-e3pazjdi 9 12 a a DT cord-252725-e3pazjdi 9 13 wide wide JJ cord-252725-e3pazjdi 9 14 range range NN cord-252725-e3pazjdi 9 15 of of IN cord-252725-e3pazjdi 9 16 remedial remedial JJ cord-252725-e3pazjdi 9 17 herbs herb NNS cord-252725-e3pazjdi 9 18 ( ( -LRB- cord-252725-e3pazjdi 9 19 thyme thyme NNS cord-252725-e3pazjdi 9 20 , , , cord-252725-e3pazjdi 9 21 oregano oregano NN cord-252725-e3pazjdi 9 22 , , , cord-252725-e3pazjdi 9 23 rosemary rosemary NN cord-252725-e3pazjdi 9 24 , , , cord-252725-e3pazjdi 9 25 sage sage NN cord-252725-e3pazjdi 9 26 , , , cord-252725-e3pazjdi 9 27 mint mint NN cord-252725-e3pazjdi 9 28 , , , cord-252725-e3pazjdi 9 29 basil basil NNP cord-252725-e3pazjdi 9 30 ) ) -RRB- cord-252725-e3pazjdi 9 31 , , , cord-252725-e3pazjdi 9 32 has have VBZ cord-252725-e3pazjdi 9 33 been be VBN cord-252725-e3pazjdi 9 34 well well JJ cord-252725-e3pazjdi 9 35 and and CC cord-252725-e3pazjdi 9 36 long long RB cord-252725-e3pazjdi 9 37 known know VBN cord-252725-e3pazjdi 9 38 for for IN cord-252725-e3pazjdi 9 39 treating treat VBG cord-252725-e3pazjdi 9 40 common common JJ cord-252725-e3pazjdi 9 41 respiratory respiratory JJ cord-252725-e3pazjdi 9 42 problems problem NNS cord-252725-e3pazjdi 9 43 and and CC cord-252725-e3pazjdi 9 44 cold cold JJ cord-252725-e3pazjdi 9 45 infections infection NNS cord-252725-e3pazjdi 9 46 . . . cord-252725-e3pazjdi 10 1 This this DT cord-252725-e3pazjdi 10 2 review review NN cord-252725-e3pazjdi 10 3 reports report VBZ cord-252725-e3pazjdi 10 4 on on IN cord-252725-e3pazjdi 10 5 the the DT cord-252725-e3pazjdi 10 6 most most RBS cord-252725-e3pazjdi 10 7 highlighted highlighted JJ cord-252725-e3pazjdi 10 8 polyphenolic polyphenolic JJ cord-252725-e3pazjdi 10 9 compounds compound NNS cord-252725-e3pazjdi 10 10 present present JJ cord-252725-e3pazjdi 10 11 in in IN cord-252725-e3pazjdi 10 12 up up IN cord-252725-e3pazjdi 10 13 to to IN cord-252725-e3pazjdi 10 14 date date NN cord-252725-e3pazjdi 10 15 literature literature NN cord-252725-e3pazjdi 10 16 and and CC cord-252725-e3pazjdi 10 17 their -PRON- PRP$ cord-252725-e3pazjdi 10 18 specific specific JJ cord-252725-e3pazjdi 10 19 antiviral antiviral JJ cord-252725-e3pazjdi 10 20 perceptive perceptive JJ cord-252725-e3pazjdi 10 21 properties property NNS cord-252725-e3pazjdi 10 22 that that WDT cord-252725-e3pazjdi 10 23 might may MD cord-252725-e3pazjdi 10 24 enhance enhance VB cord-252725-e3pazjdi 10 25 the the DT cord-252725-e3pazjdi 10 26 body body NN cord-252725-e3pazjdi 10 27 immunity immunity NN cord-252725-e3pazjdi 10 28 facing face VBG cord-252725-e3pazjdi 10 29 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 10 30 , , , cord-252725-e3pazjdi 10 31 and and CC cord-252725-e3pazjdi 10 32 other other JJ cord-252725-e3pazjdi 10 33 viral viral JJ cord-252725-e3pazjdi 10 34 infectious infectious JJ cord-252725-e3pazjdi 10 35 diseases disease NNS cord-252725-e3pazjdi 10 36 . . . cord-252725-e3pazjdi 11 1 In in IN cord-252725-e3pazjdi 11 2 fact fact NN cord-252725-e3pazjdi 11 3 , , , cord-252725-e3pazjdi 11 4 several several JJ cord-252725-e3pazjdi 11 5 studies study NNS cord-252725-e3pazjdi 11 6 and and CC cord-252725-e3pazjdi 11 7 clinical clinical JJ cord-252725-e3pazjdi 11 8 trials trial NNS cord-252725-e3pazjdi 11 9 increasingly increasingly RB cord-252725-e3pazjdi 11 10 proved prove VBD cord-252725-e3pazjdi 11 11 the the DT cord-252725-e3pazjdi 11 12 role role NN cord-252725-e3pazjdi 11 13 of of IN cord-252725-e3pazjdi 11 14 polyphenols polyphenol NNS cord-252725-e3pazjdi 11 15 in in IN cord-252725-e3pazjdi 11 16 controlling control VBG cord-252725-e3pazjdi 11 17 numerous numerous JJ cord-252725-e3pazjdi 11 18 human human JJ cord-252725-e3pazjdi 11 19 pathogens pathogen NNS cord-252725-e3pazjdi 11 20 including include VBG cord-252725-e3pazjdi 11 21 SARS SARS NNP cord-252725-e3pazjdi 11 22 and and CC cord-252725-e3pazjdi 11 23 MERS MERS NNP cord-252725-e3pazjdi 11 24 , , , cord-252725-e3pazjdi 11 25 which which WDT cord-252725-e3pazjdi 11 26 are be VBP cord-252725-e3pazjdi 11 27 quite quite RB cord-252725-e3pazjdi 11 28 similar similar JJ cord-252725-e3pazjdi 11 29 to to IN cord-252725-e3pazjdi 11 30 COVID-19 covid-19 VB cord-252725-e3pazjdi 11 31 through through IN cord-252725-e3pazjdi 11 32 the the DT cord-252725-e3pazjdi 11 33 enhancement enhancement NN cord-252725-e3pazjdi 11 34 of of IN cord-252725-e3pazjdi 11 35 host host NN cord-252725-e3pazjdi 11 36 immune immune JJ cord-252725-e3pazjdi 11 37 response response NN cord-252725-e3pazjdi 11 38 against against IN cord-252725-e3pazjdi 11 39 viral viral JJ cord-252725-e3pazjdi 11 40 infections infection NNS cord-252725-e3pazjdi 11 41 by by IN cord-252725-e3pazjdi 11 42 different different JJ cord-252725-e3pazjdi 11 43 biological biological JJ cord-252725-e3pazjdi 11 44 mechanisms mechanism NNS cord-252725-e3pazjdi 11 45 . . . cord-252725-e3pazjdi 12 1 Thus thus RB cord-252725-e3pazjdi 12 2 , , , cord-252725-e3pazjdi 12 3 polyphenols polyphenol NNS cord-252725-e3pazjdi 12 4 ought ought MD cord-252725-e3pazjdi 12 5 to to TO cord-252725-e3pazjdi 12 6 be be VB cord-252725-e3pazjdi 12 7 considered consider VBN cord-252725-e3pazjdi 12 8 as as IN cord-252725-e3pazjdi 12 9 a a DT cord-252725-e3pazjdi 12 10 potential potential JJ cord-252725-e3pazjdi 12 11 and and CC cord-252725-e3pazjdi 12 12 valuable valuable JJ cord-252725-e3pazjdi 12 13 source source NN cord-252725-e3pazjdi 12 14 for for IN cord-252725-e3pazjdi 12 15 designing design VBG cord-252725-e3pazjdi 12 16 new new JJ cord-252725-e3pazjdi 12 17 drugs drug NNS cord-252725-e3pazjdi 12 18 that that WDT cord-252725-e3pazjdi 12 19 could could MD cord-252725-e3pazjdi 12 20 be be VB cord-252725-e3pazjdi 12 21 used use VBN cord-252725-e3pazjdi 12 22 effectively effectively RB cord-252725-e3pazjdi 12 23 in in IN cord-252725-e3pazjdi 12 24 the the DT cord-252725-e3pazjdi 12 25 combat combat NN cord-252725-e3pazjdi 12 26 against against IN cord-252725-e3pazjdi 12 27 COVID‐19 COVID‐19 NNP cord-252725-e3pazjdi 12 28 and and CC cord-252725-e3pazjdi 12 29 other other JJ cord-252725-e3pazjdi 12 30 rigorous rigorous JJ cord-252725-e3pazjdi 12 31 diseases disease NNS cord-252725-e3pazjdi 12 32 . . . cord-252725-e3pazjdi 13 1 Since since IN cord-252725-e3pazjdi 13 2 the the DT cord-252725-e3pazjdi 13 3 first first JJ cord-252725-e3pazjdi 13 4 unveiling unveiling NN cord-252725-e3pazjdi 13 5 of of IN cord-252725-e3pazjdi 13 6 the the DT cord-252725-e3pazjdi 13 7 novel novel JJ cord-252725-e3pazjdi 13 8 coronavirus coronavirus NN cord-252725-e3pazjdi 13 9 in in IN cord-252725-e3pazjdi 13 10 the the DT cord-252725-e3pazjdi 13 11 city city NN cord-252725-e3pazjdi 13 12 of of IN cord-252725-e3pazjdi 13 13 Wuhan Wuhan NNP cord-252725-e3pazjdi 13 14 , , , cord-252725-e3pazjdi 13 15 Hubei Hubei NNP cord-252725-e3pazjdi 13 16 province province NN cord-252725-e3pazjdi 13 17 , , , cord-252725-e3pazjdi 13 18 China China NNP cord-252725-e3pazjdi 13 19 in in IN cord-252725-e3pazjdi 13 20 late late JJ cord-252725-e3pazjdi 13 21 December December NNP cord-252725-e3pazjdi 13 22 2019 2019 CD cord-252725-e3pazjdi 13 23 , , , cord-252725-e3pazjdi 13 24 exceptional exceptional JJ cord-252725-e3pazjdi 13 25 and and CC cord-252725-e3pazjdi 13 26 unprecedented unprecedented JJ cord-252725-e3pazjdi 13 27 dares dare NNS cord-252725-e3pazjdi 13 28 presented present VBN cord-252725-e3pazjdi 13 29 by by IN cord-252725-e3pazjdi 13 30 the the DT cord-252725-e3pazjdi 13 31 rapidly rapidly RB cord-252725-e3pazjdi 13 32 rising rise VBG cord-252725-e3pazjdi 13 33 of of IN cord-252725-e3pazjdi 13 34 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 13 35 pandemic pandemic NNP cord-252725-e3pazjdi 13 36 health health NN cord-252725-e3pazjdi 13 37 crisis crisis NN cord-252725-e3pazjdi 13 38 are be VBP cord-252725-e3pazjdi 13 39 confronting confront VBG cord-252725-e3pazjdi 13 40 people people NNS cord-252725-e3pazjdi 13 41 worldwide worldwide RB cord-252725-e3pazjdi 13 42 . . . cord-252725-e3pazjdi 14 1 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 14 2 , , , cord-252725-e3pazjdi 14 3 a a DT cord-252725-e3pazjdi 14 4 single single RB cord-252725-e3pazjdi 14 5 - - HYPH cord-252725-e3pazjdi 14 6 stranded strand VBN cord-252725-e3pazjdi 14 7 RNA RNA NNP cord-252725-e3pazjdi 14 8 virus virus NN cord-252725-e3pazjdi 14 9 is be VBZ cord-252725-e3pazjdi 14 10 actually actually RB cord-252725-e3pazjdi 14 11 complicated complicate VBN cord-252725-e3pazjdi 14 12 by by IN cord-252725-e3pazjdi 14 13 severe severe JJ cord-252725-e3pazjdi 14 14 acute acute JJ cord-252725-e3pazjdi 14 15 respiratory respiratory JJ cord-252725-e3pazjdi 14 16 syndrome syndrome NN cord-252725-e3pazjdi 14 17 coronavirus coronavirus NN cord-252725-e3pazjdi 14 18 2 2 CD cord-252725-e3pazjdi 14 19 ( ( -LRB- cord-252725-e3pazjdi 14 20 SARS SARS NNP cord-252725-e3pazjdi 14 21 - - HYPH cord-252725-e3pazjdi 14 22 CoV-2 CoV-2 NNP cord-252725-e3pazjdi 14 23 ) ) -RRB- cord-252725-e3pazjdi 14 24 , , , cord-252725-e3pazjdi 14 25 a a DT cord-252725-e3pazjdi 14 26 newly newly RB cord-252725-e3pazjdi 14 27 identified identify VBN cord-252725-e3pazjdi 14 28 virus virus NN cord-252725-e3pazjdi 14 29 alike alike RB cord-252725-e3pazjdi 14 30 SARS SARS NNP cord-252725-e3pazjdi 14 31 - - HYPH cord-252725-e3pazjdi 14 32 CoV CoV NNP cord-252725-e3pazjdi 14 33 and and CC cord-252725-e3pazjdi 14 34 MERS MERS NNP cord-252725-e3pazjdi 15 1 -CoV-2 -CoV-2 . cord-252725-e3pazjdi 16 1 that that WDT cord-252725-e3pazjdi 16 2 cause cause VBP cord-252725-e3pazjdi 16 3 the the DT cord-252725-e3pazjdi 16 4 severe severe JJ cord-252725-e3pazjdi 16 5 acute acute JJ cord-252725-e3pazjdi 16 6 respiratory respiratory JJ cord-252725-e3pazjdi 16 7 syndrome syndrome NN cord-252725-e3pazjdi 16 8 and and CC cord-252725-e3pazjdi 16 9 Middle Middle NNP cord-252725-e3pazjdi 16 10 East East NNP cord-252725-e3pazjdi 16 11 respiratory respiratory JJ cord-252725-e3pazjdi 16 12 syndrome syndrome NN cord-252725-e3pazjdi 16 13 respectively respectively RB cord-252725-e3pazjdi 17 1 [ [ -LRB- cord-252725-e3pazjdi 17 2 1 1 CD cord-252725-e3pazjdi 17 3 ] ] -RRB- cord-252725-e3pazjdi 17 4 . . . cord-252725-e3pazjdi 18 1 The the DT cord-252725-e3pazjdi 18 2 main main JJ cord-252725-e3pazjdi 18 3 symptoms symptom NNS cord-252725-e3pazjdi 18 4 of of IN cord-252725-e3pazjdi 18 5 COVID-19 covid-19 DT cord-252725-e3pazjdi 18 6 comprise comprise VBP cord-252725-e3pazjdi 18 7 fever fever NN cord-252725-e3pazjdi 18 8 , , , cord-252725-e3pazjdi 18 9 dry dry JJ cord-252725-e3pazjdi 18 10 cough cough NN cord-252725-e3pazjdi 18 11 , , , cord-252725-e3pazjdi 18 12 difficulty difficulty NN cord-252725-e3pazjdi 18 13 in in IN cord-252725-e3pazjdi 18 14 breathing breathing NN cord-252725-e3pazjdi 18 15 , , , cord-252725-e3pazjdi 18 16 fatigue fatigue NN cord-252725-e3pazjdi 18 17 , , , cord-252725-e3pazjdi 18 18 mild mild JJ cord-252725-e3pazjdi 18 19 dyspnoea dyspnoea NNS cord-252725-e3pazjdi 18 20 , , , cord-252725-e3pazjdi 18 21 sore sore JJ cord-252725-e3pazjdi 18 22 throat throat NN cord-252725-e3pazjdi 18 23 , , , cord-252725-e3pazjdi 18 24 headache headache NN cord-252725-e3pazjdi 18 25 , , , cord-252725-e3pazjdi 18 26 conjunctivitis conjunctivitis NN cord-252725-e3pazjdi 18 27 and and CC cord-252725-e3pazjdi 18 28 gastrointestinal gastrointestinal JJ cord-252725-e3pazjdi 18 29 problems problem NNS cord-252725-e3pazjdi 18 30 [ [ -LRB- cord-252725-e3pazjdi 18 31 2 2 CD cord-252725-e3pazjdi 18 32 ] ] -RRB- cord-252725-e3pazjdi 18 33 [ [ -LRB- cord-252725-e3pazjdi 18 34 3 3 CD cord-252725-e3pazjdi 18 35 ] ] -RRB- cord-252725-e3pazjdi 18 36 [ [ -LRB- cord-252725-e3pazjdi 18 37 4 4 CD cord-252725-e3pazjdi 18 38 ] ] -RRB- cord-252725-e3pazjdi 18 39 . . . cord-252725-e3pazjdi 19 1 Initially initially RB cord-252725-e3pazjdi 19 2 , , , cord-252725-e3pazjdi 19 3 the the DT cord-252725-e3pazjdi 19 4 pathogen pathogen NN cord-252725-e3pazjdi 19 5 strikes strike VBZ cord-252725-e3pazjdi 19 6 the the DT cord-252725-e3pazjdi 19 7 respiratory respiratory JJ cord-252725-e3pazjdi 19 8 tract tract NN cord-252725-e3pazjdi 19 9 particularly particularly RB cord-252725-e3pazjdi 19 10 , , , cord-252725-e3pazjdi 19 11 the the DT cord-252725-e3pazjdi 19 12 lower low JJR cord-252725-e3pazjdi 19 13 respiratory respiratory JJ cord-252725-e3pazjdi 19 14 part part NN cord-252725-e3pazjdi 19 15 , , , cord-252725-e3pazjdi 19 16 leading lead VBG cord-252725-e3pazjdi 19 17 to to IN cord-252725-e3pazjdi 19 18 a a DT cord-252725-e3pazjdi 19 19 severe severe JJ cord-252725-e3pazjdi 19 20 lung lung NN cord-252725-e3pazjdi 19 21 injury injury NN cord-252725-e3pazjdi 19 22 at at IN cord-252725-e3pazjdi 19 23 all all DT cord-252725-e3pazjdi 19 24 ages age NNS cord-252725-e3pazjdi 19 25 , , , cord-252725-e3pazjdi 19 26 subsequently subsequently RB cord-252725-e3pazjdi 19 27 in in IN cord-252725-e3pazjdi 19 28 elderly elderly JJ cord-252725-e3pazjdi 19 29 people people NNS cord-252725-e3pazjdi 19 30 and and CC cord-252725-e3pazjdi 19 31 those those DT cord-252725-e3pazjdi 19 32 immuno immuno JJ cord-252725-e3pazjdi 19 33 - - HYPH cord-252725-e3pazjdi 19 34 compromised compromise VBN cord-252725-e3pazjdi 19 35 individuals individual NNS cord-252725-e3pazjdi 19 36 in in IN cord-252725-e3pazjdi 19 37 particular particular JJ cord-252725-e3pazjdi 19 38 , , , cord-252725-e3pazjdi 19 39 it -PRON- PRP cord-252725-e3pazjdi 19 40 may may MD cord-252725-e3pazjdi 19 41 lead lead VB cord-252725-e3pazjdi 19 42 to to IN cord-252725-e3pazjdi 19 43 a a DT cord-252725-e3pazjdi 19 44 severe severe JJ cord-252725-e3pazjdi 19 45 pneumonia pneumonia NN cord-252725-e3pazjdi 19 46 associated associate VBN cord-252725-e3pazjdi 19 47 with with IN cord-252725-e3pazjdi 19 48 a a DT cord-252725-e3pazjdi 19 49 systemic systemic JJ cord-252725-e3pazjdi 19 50 and and CC cord-252725-e3pazjdi 19 51 strong strong JJ cord-252725-e3pazjdi 19 52 inflammation inflammation NN cord-252725-e3pazjdi 19 53 implicated implicate VBN cord-252725-e3pazjdi 19 54 in in IN cord-252725-e3pazjdi 19 55 airway airway NN cord-252725-e3pazjdi 19 56 damages damage NNS cord-252725-e3pazjdi 19 57 , , , cord-252725-e3pazjdi 19 58 acute acute JJ cord-252725-e3pazjdi 19 59 respiratory respiratory JJ cord-252725-e3pazjdi 19 60 distress distress NN cord-252725-e3pazjdi 19 61 syndrome syndrome NN cord-252725-e3pazjdi 19 62 ( ( -LRB- cord-252725-e3pazjdi 19 63 ARDS ARDS NNP cord-252725-e3pazjdi 19 64 ) ) -RRB- cord-252725-e3pazjdi 19 65 and and CC cord-252725-e3pazjdi 19 66 subsequently subsequently RB cord-252725-e3pazjdi 19 67 , , , cord-252725-e3pazjdi 19 68 multi multi JJ cord-252725-e3pazjdi 19 69 - - JJ cord-252725-e3pazjdi 19 70 organ organ JJ cord-252725-e3pazjdi 19 71 failure failure NN cord-252725-e3pazjdi 19 72 and and CC cord-252725-e3pazjdi 19 73 cause cause VB cord-252725-e3pazjdi 19 74 fatality fatality NN cord-252725-e3pazjdi 19 75 [ [ -LRB- cord-252725-e3pazjdi 19 76 4 4 CD cord-252725-e3pazjdi 19 77 , , , cord-252725-e3pazjdi 19 78 5 5 CD cord-252725-e3pazjdi 19 79 ] ] -RRB- cord-252725-e3pazjdi 19 80 . . . cord-252725-e3pazjdi 20 1 During during IN cord-252725-e3pazjdi 20 2 SARS SARS NNP cord-252725-e3pazjdi 20 3 - - HYPH cord-252725-e3pazjdi 20 4 CoV-2 CoV-2 NNP cord-252725-e3pazjdi 20 5 infection infection NN cord-252725-e3pazjdi 20 6 , , , cord-252725-e3pazjdi 20 7 the the DT cord-252725-e3pazjdi 20 8 viral viral JJ cord-252725-e3pazjdi 20 9 immune immune JJ cord-252725-e3pazjdi 20 10 response response NN cord-252725-e3pazjdi 20 11 is be VBZ cord-252725-e3pazjdi 20 12 divided divide VBN cord-252725-e3pazjdi 20 13 into into IN cord-252725-e3pazjdi 20 14 two two CD cord-252725-e3pazjdi 20 15 main main JJ cord-252725-e3pazjdi 20 16 phases phase NNS cord-252725-e3pazjdi 20 17 : : : cord-252725-e3pazjdi 20 18 incubation incubation NN cord-252725-e3pazjdi 20 19 ( ( -LRB- cord-252725-e3pazjdi 20 20 non non JJ cord-252725-e3pazjdi 20 21 - - JJ cord-252725-e3pazjdi 20 22 severe severe JJ cord-252725-e3pazjdi 20 23 stages stage NNS cord-252725-e3pazjdi 20 24 ) ) -RRB- cord-252725-e3pazjdi 20 25 , , , cord-252725-e3pazjdi 20 26 and and CC cord-252725-e3pazjdi 20 27 massive massive JJ cord-252725-e3pazjdi 20 28 destruction destruction NN cord-252725-e3pazjdi 20 29 ( ( -LRB- cord-252725-e3pazjdi 20 30 severe severe JJ cord-252725-e3pazjdi 20 31 stages stage NNS cord-252725-e3pazjdi 20 32 ) ) -RRB- cord-252725-e3pazjdi 20 33 . . . cord-252725-e3pazjdi 21 1 In in IN cord-252725-e3pazjdi 21 2 the the DT cord-252725-e3pazjdi 21 3 first first JJ cord-252725-e3pazjdi 21 4 phase phase NN cord-252725-e3pazjdi 21 5 , , , cord-252725-e3pazjdi 21 6 a a DT cord-252725-e3pazjdi 21 7 specific specific JJ cord-252725-e3pazjdi 21 8 adaptive adaptive JJ cord-252725-e3pazjdi 21 9 immune immune JJ cord-252725-e3pazjdi 21 10 response response NN cord-252725-e3pazjdi 21 11 is be VBZ cord-252725-e3pazjdi 21 12 vital vital JJ cord-252725-e3pazjdi 21 13 to to TO cord-252725-e3pazjdi 21 14 remove remove VB cord-252725-e3pazjdi 21 15 the the DT cord-252725-e3pazjdi 21 16 virus virus NN cord-252725-e3pazjdi 21 17 and and CC cord-252725-e3pazjdi 21 18 prevents prevent VBZ cord-252725-e3pazjdi 21 19 the the DT cord-252725-e3pazjdi 21 20 initiation initiation NN cord-252725-e3pazjdi 21 21 of of IN cord-252725-e3pazjdi 21 22 the the DT cord-252725-e3pazjdi 21 23 second second JJ cord-252725-e3pazjdi 21 24 phase phase NN cord-252725-e3pazjdi 21 25 of of IN cord-252725-e3pazjdi 21 26 virus virus NN cord-252725-e3pazjdi 21 27 infection infection NN cord-252725-e3pazjdi 21 28 from from IN cord-252725-e3pazjdi 21 29 commencing commence VBG cord-252725-e3pazjdi 21 30 . . . cord-252725-e3pazjdi 22 1 Therefore therefore RB cord-252725-e3pazjdi 22 2 , , , cord-252725-e3pazjdi 22 3 good good JJ cord-252725-e3pazjdi 22 4 general general JJ cord-252725-e3pazjdi 22 5 health health NN cord-252725-e3pazjdi 22 6 and and CC cord-252725-e3pazjdi 22 7 appropriate appropriate JJ cord-252725-e3pazjdi 22 8 genetic genetic JJ cord-252725-e3pazjdi 22 9 background background NN cord-252725-e3pazjdi 22 10 of of IN cord-252725-e3pazjdi 22 11 the the DT cord-252725-e3pazjdi 22 12 host host NN cord-252725-e3pazjdi 22 13 is be VBZ cord-252725-e3pazjdi 22 14 crucial crucial JJ cord-252725-e3pazjdi 22 15 for for IN cord-252725-e3pazjdi 22 16 the the DT cord-252725-e3pazjdi 22 17 development development NN cord-252725-e3pazjdi 22 18 of of IN cord-252725-e3pazjdi 22 19 an an DT cord-252725-e3pazjdi 22 20 endogenous endogenous JJ cord-252725-e3pazjdi 22 21 protective protective JJ cord-252725-e3pazjdi 22 22 immune immune JJ cord-252725-e3pazjdi 22 23 response response NN cord-252725-e3pazjdi 22 24 at at IN cord-252725-e3pazjdi 22 25 the the DT cord-252725-e3pazjdi 22 26 incubation incubation NN cord-252725-e3pazjdi 22 27 and and CC cord-252725-e3pazjdi 22 28 non non JJ cord-252725-e3pazjdi 22 29 - - JJ cord-252725-e3pazjdi 22 30 severe severe JJ cord-252725-e3pazjdi 22 31 stages stage NNS cord-252725-e3pazjdi 22 32 that that WDT cord-252725-e3pazjdi 22 33 produces produce VBZ cord-252725-e3pazjdi 22 34 specific specific JJ cord-252725-e3pazjdi 22 35 antiviral antiviral JJ cord-252725-e3pazjdi 22 36 immunity immunity NN cord-252725-e3pazjdi 22 37 . . . cord-252725-e3pazjdi 23 1 However however RB cord-252725-e3pazjdi 23 2 , , , cord-252725-e3pazjdi 23 3 in in IN cord-252725-e3pazjdi 23 4 the the DT cord-252725-e3pazjdi 23 5 case case NN cord-252725-e3pazjdi 23 6 of of IN cord-252725-e3pazjdi 23 7 an an DT cord-252725-e3pazjdi 23 8 impaired impaired JJ cord-252725-e3pazjdi 23 9 immune immune JJ cord-252725-e3pazjdi 23 10 response response NN cord-252725-e3pazjdi 23 11 ( ( -LRB- cord-252725-e3pazjdi 23 12 second second JJ cord-252725-e3pazjdi 23 13 phase phase NN cord-252725-e3pazjdi 23 14 ) ) -RRB- cord-252725-e3pazjdi 23 15 , , , cord-252725-e3pazjdi 23 16 virus virus NN cord-252725-e3pazjdi 23 17 will will MD cord-252725-e3pazjdi 23 18 spread spread VB cord-252725-e3pazjdi 23 19 and and CC cord-252725-e3pazjdi 23 20 massive massive JJ cord-252725-e3pazjdi 23 21 destruction destruction NN cord-252725-e3pazjdi 23 22 of of IN cord-252725-e3pazjdi 23 23 the the DT cord-252725-e3pazjdi 23 24 affected affect VBN cord-252725-e3pazjdi 23 25 tissues tissue NNS cord-252725-e3pazjdi 23 26 will will MD cord-252725-e3pazjdi 23 27 occur occur VB cord-252725-e3pazjdi 23 28 , , , cord-252725-e3pazjdi 23 29 followed follow VBN cord-252725-e3pazjdi 23 30 by by IN cord-252725-e3pazjdi 23 31 an an DT cord-252725-e3pazjdi 23 32 induced induce VBN cord-252725-e3pazjdi 23 33 innate innate JJ cord-252725-e3pazjdi 23 34 inflammation inflammation NN cord-252725-e3pazjdi 23 35 in in IN cord-252725-e3pazjdi 23 36 lungs lung NNS cord-252725-e3pazjdi 23 37 mediated mediate VBN cord-252725-e3pazjdi 23 38 by by IN cord-252725-e3pazjdi 23 39 proinflammatory proinflammatory JJ cord-252725-e3pazjdi 23 40 macrophages macrophage NNS cord-252725-e3pazjdi 23 41 , , , cord-252725-e3pazjdi 23 42 granulocytes granulocyte NNS cord-252725-e3pazjdi 23 43 , , , cord-252725-e3pazjdi 23 44 generation generation NN cord-252725-e3pazjdi 23 45 of of IN cord-252725-e3pazjdi 23 46 proinflammatory proinflammatory JJ cord-252725-e3pazjdi 23 47 cytokines cytokine NNS cord-252725-e3pazjdi 23 48 and and CC cord-252725-e3pazjdi 23 49 chemokines chemokine NNS cord-252725-e3pazjdi 23 50 such such JJ cord-252725-e3pazjdi 23 51 as as IN cord-252725-e3pazjdi 23 52 IL-6 IL-6 NNP cord-252725-e3pazjdi 23 53 and and CC cord-252725-e3pazjdi 23 54 IP-10 IP-10 NNP cord-252725-e3pazjdi 23 55 , , , cord-252725-e3pazjdi 23 56 macrophage macrophage NN cord-252725-e3pazjdi 23 57 inflammatory inflammatory JJ cord-252725-e3pazjdi 23 58 protein protein NN cord-252725-e3pazjdi 23 59 1 1 CD cord-252725-e3pazjdi 23 60 such such JJ cord-252725-e3pazjdi 23 61 as as IN cord-252725-e3pazjdi 23 62 MIP1α MIP1α NNP cord-252725-e3pazjdi 23 63 , , , cord-252725-e3pazjdi 23 64 MIP1β MIP1β NNP cord-252725-e3pazjdi 23 65 and and CC cord-252725-e3pazjdi 23 66 MCP1 MCP1 NNP cord-252725-e3pazjdi 23 67 . . . cord-252725-e3pazjdi 24 1 These these DT cord-252725-e3pazjdi 24 2 inflammatory inflammatory JJ cord-252725-e3pazjdi 24 3 molecules molecule NNS cord-252725-e3pazjdi 24 4 attract attract VBP cord-252725-e3pazjdi 24 5 monocytes monocyte NNS cord-252725-e3pazjdi 24 6 , , , cord-252725-e3pazjdi 24 7 macrophages macrophage NNS cord-252725-e3pazjdi 24 8 and and CC cord-252725-e3pazjdi 24 9 T t NN cord-252725-e3pazjdi 24 10 cells cell NNS cord-252725-e3pazjdi 24 11 to to IN cord-252725-e3pazjdi 24 12 the the DT cord-252725-e3pazjdi 24 13 site site NN cord-252725-e3pazjdi 24 14 of of IN cord-252725-e3pazjdi 24 15 infection infection NN cord-252725-e3pazjdi 24 16 , , , cord-252725-e3pazjdi 24 17 promoting promote VBG cord-252725-e3pazjdi 24 18 further further JJ cord-252725-e3pazjdi 24 19 inflammation inflammation NN cord-252725-e3pazjdi 24 20 creating create VBG cord-252725-e3pazjdi 24 21 overproduction overproduction NN cord-252725-e3pazjdi 24 22 of of IN cord-252725-e3pazjdi 24 23 pro pro JJ cord-252725-e3pazjdi 24 24 - - JJ cord-252725-e3pazjdi 24 25 inflammatory inflammatory JJ cord-252725-e3pazjdi 24 26 cytokines cytokine NNS cord-252725-e3pazjdi 24 27 , , , cord-252725-e3pazjdi 24 28 which which WDT cord-252725-e3pazjdi 24 29 ultimately ultimately RB cord-252725-e3pazjdi 24 30 damage damage VBP cord-252725-e3pazjdi 24 31 the the DT cord-252725-e3pazjdi 24 32 lung lung NN cord-252725-e3pazjdi 24 33 structure structure NN cord-252725-e3pazjdi 24 34 and and CC cord-252725-e3pazjdi 24 35 then then RB cord-252725-e3pazjdi 24 36 the the DT cord-252725-e3pazjdi 24 37 resulting result VBG cord-252725-e3pazjdi 24 38 cytokine cytokine NN cord-252725-e3pazjdi 24 39 storm storm NN cord-252725-e3pazjdi 24 40 enters enter VBZ cord-252725-e3pazjdi 24 41 the the DT cord-252725-e3pazjdi 24 42 circulation circulation NN cord-252725-e3pazjdi 24 43 system system NN cord-252725-e3pazjdi 24 44 and and CC cord-252725-e3pazjdi 24 45 reaches reach VBZ cord-252725-e3pazjdi 24 46 other other JJ cord-252725-e3pazjdi 24 47 organs organ NNS cord-252725-e3pazjdi 24 48 , , , cord-252725-e3pazjdi 24 49 leading lead VBG cord-252725-e3pazjdi 24 50 to to IN cord-252725-e3pazjdi 24 51 a a DT cord-252725-e3pazjdi 24 52 multi multi JJ cord-252725-e3pazjdi 24 53 - - JJ cord-252725-e3pazjdi 24 54 organ organ JJ cord-252725-e3pazjdi 24 55 damage damage NN cord-252725-e3pazjdi 24 56 [ [ -LRB- cord-252725-e3pazjdi 24 57 4 4 CD cord-252725-e3pazjdi 24 58 , , , cord-252725-e3pazjdi 24 59 6 6 CD cord-252725-e3pazjdi 24 60 , , , cord-252725-e3pazjdi 24 61 7 7 CD cord-252725-e3pazjdi 24 62 ] ] -RRB- cord-252725-e3pazjdi 24 63 . . . cord-252725-e3pazjdi 25 1 Actually actually RB cord-252725-e3pazjdi 25 2 , , , cord-252725-e3pazjdi 25 3 data datum NNS cord-252725-e3pazjdi 25 4 indicated indicate VBD cord-252725-e3pazjdi 25 5 that that IN cord-252725-e3pazjdi 25 6 activation activation NN cord-252725-e3pazjdi 25 7 of of IN cord-252725-e3pazjdi 25 8 the the DT cord-252725-e3pazjdi 25 9 nuclear nuclear JJ cord-252725-e3pazjdi 25 10 factor factor NN cord-252725-e3pazjdi 25 11 ( ( -LRB- cord-252725-e3pazjdi 25 12 NF)-κB NF)-κB NNP cord-252725-e3pazjdi 25 13 transcription transcription NN cord-252725-e3pazjdi 25 14 factor factor NN cord-252725-e3pazjdi 25 15 ( ( -LRB- cord-252725-e3pazjdi 25 16 NF nf NN cord-252725-e3pazjdi 25 17 - - HYPH cord-252725-e3pazjdi 25 18 κB κB NNP cord-252725-e3pazjdi 25 19 ) ) -RRB- cord-252725-e3pazjdi 25 20 signaling signal VBG cord-252725-e3pazjdi 25 21 pathway pathway NN cord-252725-e3pazjdi 25 22 represents represent VBZ cord-252725-e3pazjdi 25 23 a a DT cord-252725-e3pazjdi 25 24 major major JJ cord-252725-e3pazjdi 25 25 contribution contribution NN cord-252725-e3pazjdi 25 26 to to IN cord-252725-e3pazjdi 25 27 the the DT cord-252725-e3pazjdi 25 28 inflammation inflammation NN cord-252725-e3pazjdi 25 29 induced induce VBN cord-252725-e3pazjdi 25 30 post post NN cord-252725-e3pazjdi 25 31 SARS SARS NNP cord-252725-e3pazjdi 25 32 - - HYPH cord-252725-e3pazjdi 25 33 CoV CoV NNP cord-252725-e3pazjdi 25 34 infection infection NN cord-252725-e3pazjdi 25 35 and and CC cord-252725-e3pazjdi 25 36 that that IN cord-252725-e3pazjdi 25 37 NF nf NN cord-252725-e3pazjdi 25 38 - - HYPH cord-252725-e3pazjdi 25 39 κB κB NNP cord-252725-e3pazjdi 25 40 inhibitors inhibitor NNS cord-252725-e3pazjdi 25 41 are be VBP cord-252725-e3pazjdi 25 42 promising promise VBG cord-252725-e3pazjdi 25 43 antiviral antiviral JJ cord-252725-e3pazjdi 25 44 drugs drug NNS cord-252725-e3pazjdi 25 45 against against IN cord-252725-e3pazjdi 25 46 infections infection NNS cord-252725-e3pazjdi 25 47 caused cause VBN cord-252725-e3pazjdi 25 48 by by IN cord-252725-e3pazjdi 25 49 the the DT cord-252725-e3pazjdi 25 50 virus virus NN cord-252725-e3pazjdi 25 51 and and CC cord-252725-e3pazjdi 25 52 potentially potentially RB cord-252725-e3pazjdi 25 53 other other JJ cord-252725-e3pazjdi 25 54 pathogenic pathogenic JJ cord-252725-e3pazjdi 25 55 human human JJ cord-252725-e3pazjdi 25 56 coronaviruses coronaviruse NNS cord-252725-e3pazjdi 25 57 [ [ -LRB- cord-252725-e3pazjdi 25 58 8 8 CD cord-252725-e3pazjdi 25 59 ] ] -RRB- cord-252725-e3pazjdi 25 60 . . . cord-252725-e3pazjdi 26 1 In in IN cord-252725-e3pazjdi 26 2 this this DT cord-252725-e3pazjdi 26 3 regards regard NNS cord-252725-e3pazjdi 26 4 , , , cord-252725-e3pazjdi 26 5 several several JJ cord-252725-e3pazjdi 26 6 clinical clinical JJ cord-252725-e3pazjdi 26 7 trials trial NNS cord-252725-e3pazjdi 26 8 based base VBN cord-252725-e3pazjdi 26 9 mainly mainly RB cord-252725-e3pazjdi 26 10 on on IN cord-252725-e3pazjdi 26 11 anti anti JJ cord-252725-e3pazjdi 26 12 - - JJ cord-252725-e3pazjdi 26 13 oxidant oxidant JJ cord-252725-e3pazjdi 26 14 , , , cord-252725-e3pazjdi 26 15 anti anti JJ cord-252725-e3pazjdi 26 16 - - JJ cord-252725-e3pazjdi 26 17 inflammatory inflammatory JJ cord-252725-e3pazjdi 26 18 , , , cord-252725-e3pazjdi 26 19 immunomodulatory immunomodulatory JJ cord-252725-e3pazjdi 26 20 drugs drug NNS cord-252725-e3pazjdi 26 21 and and CC cord-252725-e3pazjdi 26 22 other other JJ cord-252725-e3pazjdi 26 23 therapies therapy NNS cord-252725-e3pazjdi 26 24 are be VBP cord-252725-e3pazjdi 26 25 conducted conduct VBN cord-252725-e3pazjdi 26 26 to to TO cord-252725-e3pazjdi 26 27 find find VB cord-252725-e3pazjdi 26 28 a a DT cord-252725-e3pazjdi 26 29 possible possible JJ cord-252725-e3pazjdi 26 30 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 26 31 treatment treatment NN cord-252725-e3pazjdi 26 32 [ [ -LRB- cord-252725-e3pazjdi 26 33 9 9 CD cord-252725-e3pazjdi 26 34 ] ] -RRB- cord-252725-e3pazjdi 26 35 . . . cord-252725-e3pazjdi 27 1 According accord VBG cord-252725-e3pazjdi 27 2 to to IN cord-252725-e3pazjdi 27 3 world world NNP cord-252725-e3pazjdi 27 4 health health NNP cord-252725-e3pazjdi 27 5 organization organization NN cord-252725-e3pazjdi 27 6 ( ( -LRB- cord-252725-e3pazjdi 27 7 WHO who WP cord-252725-e3pazjdi 27 8 ) ) -RRB- cord-252725-e3pazjdi 27 9 , , , cord-252725-e3pazjdi 27 10 appropriate appropriate JJ cord-252725-e3pazjdi 27 11 nutrition nutrition NN cord-252725-e3pazjdi 27 12 and and CC cord-252725-e3pazjdi 27 13 well well RB cord-252725-e3pazjdi 27 14 - - HYPH cord-252725-e3pazjdi 27 15 balanced balance VBN cord-252725-e3pazjdi 27 16 diet diet NN cord-252725-e3pazjdi 27 17 are be VBP cord-252725-e3pazjdi 27 18 vital vital JJ cord-252725-e3pazjdi 27 19 to to TO cord-252725-e3pazjdi 27 20 be be VB cord-252725-e3pazjdi 27 21 healthier healthy JJR cord-252725-e3pazjdi 27 22 with with IN cord-252725-e3pazjdi 27 23 stronger strong JJR cord-252725-e3pazjdi 27 24 immune immune JJ cord-252725-e3pazjdi 27 25 systems system NNS cord-252725-e3pazjdi 27 26 and and CC cord-252725-e3pazjdi 27 27 lower low JJR cord-252725-e3pazjdi 27 28 risk risk NN cord-252725-e3pazjdi 27 29 of of IN cord-252725-e3pazjdi 27 30 chronic chronic JJ cord-252725-e3pazjdi 27 31 illnesses illness NNS cord-252725-e3pazjdi 27 32 and and CC cord-252725-e3pazjdi 27 33 infectious infectious JJ cord-252725-e3pazjdi 27 34 diseases disease NNS cord-252725-e3pazjdi 27 35 . . . cord-252725-e3pazjdi 28 1 Since since IN cord-252725-e3pazjdi 28 2 , , , cord-252725-e3pazjdi 28 3 the the DT cord-252725-e3pazjdi 28 4 human human JJ cord-252725-e3pazjdi 28 5 immune immune JJ cord-252725-e3pazjdi 28 6 response response NN cord-252725-e3pazjdi 28 7 has have VBZ cord-252725-e3pazjdi 28 8 often often RB cord-252725-e3pazjdi 28 9 been be VBN cord-252725-e3pazjdi 28 10 shown show VBN cord-252725-e3pazjdi 28 11 to to TO cord-252725-e3pazjdi 28 12 be be VB cord-252725-e3pazjdi 28 13 weakened weaken VBN cord-252725-e3pazjdi 28 14 by by IN cord-252725-e3pazjdi 28 15 insufficient insufficient JJ cord-252725-e3pazjdi 28 16 nutrition nutrition NN cord-252725-e3pazjdi 28 17 in in IN cord-252725-e3pazjdi 28 18 several several JJ cord-252725-e3pazjdi 28 19 model model NN cord-252725-e3pazjdi 28 20 systems system NNS cord-252725-e3pazjdi 28 21 [ [ -LRB- cord-252725-e3pazjdi 28 22 10 10 CD cord-252725-e3pazjdi 28 23 ] ] -RRB- cord-252725-e3pazjdi 28 24 . . . cord-252725-e3pazjdi 29 1 Therefore therefore RB cord-252725-e3pazjdi 29 2 , , , cord-252725-e3pazjdi 29 3 nutrition nutrition NN cord-252725-e3pazjdi 29 4 intervention intervention NN cord-252725-e3pazjdi 29 5 and and CC cord-252725-e3pazjdi 29 6 therapy therapy NN cord-252725-e3pazjdi 29 7 need need VBP cord-252725-e3pazjdi 29 8 to to TO cord-252725-e3pazjdi 29 9 be be VB cord-252725-e3pazjdi 29 10 considered consider VBN cord-252725-e3pazjdi 29 11 as as IN cord-252725-e3pazjdi 29 12 an an DT cord-252725-e3pazjdi 29 13 integral integral JJ cord-252725-e3pazjdi 29 14 part part NN cord-252725-e3pazjdi 29 15 of of IN cord-252725-e3pazjdi 29 16 the the DT cord-252725-e3pazjdi 29 17 approach approach NN cord-252725-e3pazjdi 29 18 to to TO cord-252725-e3pazjdi 29 19 patient patient VB cord-252725-e3pazjdi 29 20 's 's POS cord-252725-e3pazjdi 29 21 victim victim NN cord-252725-e3pazjdi 29 22 of of IN cord-252725-e3pazjdi 29 23 COVID-19 covid-19 JJ cord-252725-e3pazjdi 29 24 infection infection NN cord-252725-e3pazjdi 29 25 especially especially RB cord-252725-e3pazjdi 29 26 among among IN cord-252725-e3pazjdi 29 27 the the DT cord-252725-e3pazjdi 29 28 general general JJ cord-252725-e3pazjdi 29 29 health health NN cord-252725-e3pazjdi 29 30 workers worker NNS cord-252725-e3pazjdi 29 31 [ [ -LRB- cord-252725-e3pazjdi 29 32 3 3 CD cord-252725-e3pazjdi 29 33 , , , cord-252725-e3pazjdi 29 34 11 11 CD cord-252725-e3pazjdi 29 35 ] ] -RRB- cord-252725-e3pazjdi 29 36 . . . cord-252725-e3pazjdi 30 1 In in IN cord-252725-e3pazjdi 30 2 fact fact NN cord-252725-e3pazjdi 30 3 , , , cord-252725-e3pazjdi 30 4 several several JJ cord-252725-e3pazjdi 30 5 epidemiological epidemiological JJ cord-252725-e3pazjdi 30 6 studies study NNS cord-252725-e3pazjdi 30 7 have have VBP cord-252725-e3pazjdi 30 8 repeatedly repeatedly RB cord-252725-e3pazjdi 30 9 shown show VBN cord-252725-e3pazjdi 30 10 an an DT cord-252725-e3pazjdi 30 11 inverse inverse JJ cord-252725-e3pazjdi 30 12 association association NN cord-252725-e3pazjdi 30 13 between between IN cord-252725-e3pazjdi 30 14 the the DT cord-252725-e3pazjdi 30 15 risk risk NN cord-252725-e3pazjdi 30 16 of of IN cord-252725-e3pazjdi 30 17 chronic chronic JJ cord-252725-e3pazjdi 30 18 human human JJ cord-252725-e3pazjdi 30 19 diseases disease NNS cord-252725-e3pazjdi 30 20 and and CC cord-252725-e3pazjdi 30 21 the the DT cord-252725-e3pazjdi 30 22 consumption consumption NN cord-252725-e3pazjdi 30 23 of of IN cord-252725-e3pazjdi 30 24 polyphenolic polyphenolic JJ cord-252725-e3pazjdi 30 25 rich rich JJ cord-252725-e3pazjdi 30 26 diet diet NN cord-252725-e3pazjdi 30 27 [ [ -LRB- cord-252725-e3pazjdi 30 28 12 12 CD cord-252725-e3pazjdi 30 29 ] ] -RRB- cord-252725-e3pazjdi 30 30 . . . cord-252725-e3pazjdi 31 1 In in IN cord-252725-e3pazjdi 31 2 fact fact NN cord-252725-e3pazjdi 31 3 , , , cord-252725-e3pazjdi 31 4 polyphenols polyphenol NNS cord-252725-e3pazjdi 31 5 , , , cord-252725-e3pazjdi 31 6 essential essential JJ cord-252725-e3pazjdi 31 7 micronutrients micronutrient NNS cord-252725-e3pazjdi 31 8 in in IN cord-252725-e3pazjdi 31 9 human human JJ cord-252725-e3pazjdi 31 10 diet diet NN cord-252725-e3pazjdi 31 11 , , , cord-252725-e3pazjdi 31 12 constitute constitute VB cord-252725-e3pazjdi 31 13 one one CD cord-252725-e3pazjdi 31 14 of of IN cord-252725-e3pazjdi 31 15 the the DT cord-252725-e3pazjdi 31 16 most most RBS cord-252725-e3pazjdi 31 17 numerous numerous JJ cord-252725-e3pazjdi 31 18 and and CC cord-252725-e3pazjdi 31 19 ubiquitous ubiquitous JJ cord-252725-e3pazjdi 31 20 group group NN cord-252725-e3pazjdi 31 21 with with IN cord-252725-e3pazjdi 31 22 more more JJR cord-252725-e3pazjdi 31 23 than than IN cord-252725-e3pazjdi 31 24 8000 8000 CD cord-252725-e3pazjdi 31 25 polyphenolic polyphenolic JJ cord-252725-e3pazjdi 31 26 compounds compound NNS cord-252725-e3pazjdi 31 27 identified identify VBN cord-252725-e3pazjdi 31 28 in in IN cord-252725-e3pazjdi 31 29 the the DT cord-252725-e3pazjdi 31 30 plant plant NN cord-252725-e3pazjdi 31 31 kingdom kingdom NN cord-252725-e3pazjdi 31 32 . . . cord-252725-e3pazjdi 32 1 In in IN cord-252725-e3pazjdi 32 2 the the DT cord-252725-e3pazjdi 32 3 past past JJ cord-252725-e3pazjdi 32 4 decades decade NNS cord-252725-e3pazjdi 32 5 , , , cord-252725-e3pazjdi 32 6 polyphenols polyphenol NNS cord-252725-e3pazjdi 32 7 ( ( -LRB- cord-252725-e3pazjdi 32 8 phenolic phenolic JJ cord-252725-e3pazjdi 32 9 acids acid NNS cord-252725-e3pazjdi 32 10 , , , cord-252725-e3pazjdi 32 11 flavonoids flavonoid NNS cord-252725-e3pazjdi 32 12 , , , cord-252725-e3pazjdi 32 13 stilbenes stilbene NNS cord-252725-e3pazjdi 32 14 , , , cord-252725-e3pazjdi 32 15 and and CC cord-252725-e3pazjdi 32 16 lignans lignans NNP cord-252725-e3pazjdi 32 17 [ [ -LRB- cord-252725-e3pazjdi 32 18 13 13 CD cord-252725-e3pazjdi 32 19 ] ] -RRB- cord-252725-e3pazjdi 32 20 have have VBP cord-252725-e3pazjdi 32 21 been be VBN cord-252725-e3pazjdi 32 22 intensively intensively RB cord-252725-e3pazjdi 32 23 studied study VBN cord-252725-e3pazjdi 32 24 due due IN cord-252725-e3pazjdi 32 25 to to IN cord-252725-e3pazjdi 32 26 their -PRON- PRP$ cord-252725-e3pazjdi 32 27 countless countless JJ cord-252725-e3pazjdi 32 28 benefits benefit NNS cord-252725-e3pazjdi 32 29 for for IN cord-252725-e3pazjdi 32 30 human human JJ cord-252725-e3pazjdi 32 31 health health NN cord-252725-e3pazjdi 32 32 particularly particularly RB cord-252725-e3pazjdi 32 33 , , , cord-252725-e3pazjdi 32 34 their -PRON- PRP$ cord-252725-e3pazjdi 32 35 strong strong JJ cord-252725-e3pazjdi 32 36 anti anti JJ cord-252725-e3pazjdi 32 37 - - JJ cord-252725-e3pazjdi 32 38 oxidant oxidant JJ cord-252725-e3pazjdi 32 39 and and CC cord-252725-e3pazjdi 32 40 anti anti JJ cord-252725-e3pazjdi 32 41 - - JJ cord-252725-e3pazjdi 32 42 inflammatory inflammatory JJ cord-252725-e3pazjdi 32 43 proprieties propriety NNS cord-252725-e3pazjdi 32 44 [ [ -LRB- cord-252725-e3pazjdi 32 45 14 14 CD cord-252725-e3pazjdi 32 46 ] ] -RRB- cord-252725-e3pazjdi 32 47 . . . cord-252725-e3pazjdi 33 1 Moreover moreover RB cord-252725-e3pazjdi 33 2 , , , cord-252725-e3pazjdi 33 3 the the DT cord-252725-e3pazjdi 33 4 newly newly RB cord-252725-e3pazjdi 33 5 emerging emerge VBG cord-252725-e3pazjdi 33 6 diseases disease NNS cord-252725-e3pazjdi 33 7 such such JJ cord-252725-e3pazjdi 33 8 as as IN cord-252725-e3pazjdi 33 9 the the DT cord-252725-e3pazjdi 33 10 novel novel NN cord-252725-e3pazjdi 33 11 COVID-19 covid-19 NN cord-252725-e3pazjdi 33 12 and and CC cord-252725-e3pazjdi 33 13 other other JJ cord-252725-e3pazjdi 33 14 infectious infectious JJ cord-252725-e3pazjdi 33 15 diseases disease NNS cord-252725-e3pazjdi 33 16 that that WDT cord-252725-e3pazjdi 33 17 impose impose VBP cord-252725-e3pazjdi 33 18 grand grand JJ cord-252725-e3pazjdi 33 19 burden burden NN cord-252725-e3pazjdi 33 20 on on IN cord-252725-e3pazjdi 33 21 both both DT cord-252725-e3pazjdi 33 22 human human JJ cord-252725-e3pazjdi 33 23 health health NN cord-252725-e3pazjdi 33 24 and and CC cord-252725-e3pazjdi 33 25 economy economy NN cord-252725-e3pazjdi 33 26 worldwide worldwide RB cord-252725-e3pazjdi 33 27 , , , cord-252725-e3pazjdi 33 28 require require VBP cord-252725-e3pazjdi 33 29 urgent urgent JJ cord-252725-e3pazjdi 33 30 research research NN cord-252725-e3pazjdi 33 31 for for IN cord-252725-e3pazjdi 33 32 a a DT cord-252725-e3pazjdi 33 33 novel novel JJ cord-252725-e3pazjdi 33 34 antiviral antiviral JJ cord-252725-e3pazjdi 33 35 drug drug NN cord-252725-e3pazjdi 33 36 preferably preferably RB cord-252725-e3pazjdi 33 37 from from IN cord-252725-e3pazjdi 33 38 a a DT cord-252725-e3pazjdi 33 39 natural natural JJ cord-252725-e3pazjdi 33 40 origin origin NN cord-252725-e3pazjdi 33 41 such such JJ cord-252725-e3pazjdi 33 42 as as IN cord-252725-e3pazjdi 33 43 polyphenols polyphenol NNS cord-252725-e3pazjdi 33 44 [ [ -LRB- cord-252725-e3pazjdi 33 45 15 15 CD cord-252725-e3pazjdi 33 46 , , , cord-252725-e3pazjdi 33 47 16 16 CD cord-252725-e3pazjdi 33 48 ] ] -RRB- cord-252725-e3pazjdi 33 49 . . . cord-252725-e3pazjdi 34 1 The the DT cord-252725-e3pazjdi 34 2 polyphenols polyphenol NNS cord-252725-e3pazjdi 34 3 antiviral antiviral JJ cord-252725-e3pazjdi 34 4 effect effect NN cord-252725-e3pazjdi 34 5 is be VBZ cord-252725-e3pazjdi 34 6 due due JJ cord-252725-e3pazjdi 34 7 to to IN cord-252725-e3pazjdi 34 8 the the DT cord-252725-e3pazjdi 34 9 interactions interaction NNS cord-252725-e3pazjdi 34 10 between between IN cord-252725-e3pazjdi 34 11 the the DT cord-252725-e3pazjdi 34 12 phenyl phenyl NNP cord-252725-e3pazjdi 34 13 rings ring NNS cord-252725-e3pazjdi 34 14 and and CC cord-252725-e3pazjdi 34 15 viral viral JJ cord-252725-e3pazjdi 34 16 proteins protein NNS cord-252725-e3pazjdi 34 17 and/or and/or CC cord-252725-e3pazjdi 34 18 RNA RNA NNP cord-252725-e3pazjdi 34 19 , , , cord-252725-e3pazjdi 34 20 or or CC cord-252725-e3pazjdi 34 21 via via IN cord-252725-e3pazjdi 34 22 their -PRON- PRP$ cord-252725-e3pazjdi 34 23 capacity capacity NN cord-252725-e3pazjdi 34 24 to to TO cord-252725-e3pazjdi 34 25 interfere interfere VB cord-252725-e3pazjdi 34 26 with with IN cord-252725-e3pazjdi 34 27 the the DT cord-252725-e3pazjdi 34 28 host host NN cord-252725-e3pazjdi 34 29 cell cell NN cord-252725-e3pazjdi 34 30 defense defense NN cord-252725-e3pazjdi 34 31 by by IN cord-252725-e3pazjdi 34 32 regulating regulate VBG cord-252725-e3pazjdi 34 33 MAP MAP NNP cord-252725-e3pazjdi 34 34 kinase kinase NN cord-252725-e3pazjdi 34 35 signaling signal VBG cord-252725-e3pazjdi 34 36 [ [ -LRB- cord-252725-e3pazjdi 34 37 17 17 CD cord-252725-e3pazjdi 34 38 , , , cord-252725-e3pazjdi 34 39 18 18 CD cord-252725-e3pazjdi 34 40 ] ] -RRB- cord-252725-e3pazjdi 34 41 . . . cord-252725-e3pazjdi 35 1 It -PRON- PRP cord-252725-e3pazjdi 35 2 is be VBZ cord-252725-e3pazjdi 35 3 noteworthy noteworthy JJ cord-252725-e3pazjdi 35 4 that that IN cord-252725-e3pazjdi 35 5 the the DT cord-252725-e3pazjdi 35 6 antiviral antiviral JJ cord-252725-e3pazjdi 35 7 effect effect NN cord-252725-e3pazjdi 35 8 of of IN cord-252725-e3pazjdi 35 9 polyphenols polyphenol NNS cord-252725-e3pazjdi 35 10 is be VBZ cord-252725-e3pazjdi 35 11 not not RB cord-252725-e3pazjdi 35 12 significantly significantly RB cord-252725-e3pazjdi 35 13 affected affect VBN cord-252725-e3pazjdi 35 14 by by IN cord-252725-e3pazjdi 35 15 viral viral JJ cord-252725-e3pazjdi 35 16 mutations mutation NNS cord-252725-e3pazjdi 35 17 due due IN cord-252725-e3pazjdi 35 18 to to IN cord-252725-e3pazjdi 35 19 their -PRON- PRP$ cord-252725-e3pazjdi 35 20 binding bind VBG cord-252725-e3pazjdi 35 21 capacity capacity NN cord-252725-e3pazjdi 35 22 to to IN cord-252725-e3pazjdi 35 23 the the DT cord-252725-e3pazjdi 35 24 viral viral JJ cord-252725-e3pazjdi 35 25 envelope envelope NN cord-252725-e3pazjdi 35 26 lipids lipid NNS cord-252725-e3pazjdi 35 27 or or CC cord-252725-e3pazjdi 35 28 sugar sugar NN cord-252725-e3pazjdi 35 29 moieties moiety NNS cord-252725-e3pazjdi 35 30 [ [ -LRB- cord-252725-e3pazjdi 35 31 19 19 CD cord-252725-e3pazjdi 35 32 ] ] -RRB- cord-252725-e3pazjdi 35 33 . . . cord-252725-e3pazjdi 36 1 These these DT cord-252725-e3pazjdi 36 2 enormous enormous JJ cord-252725-e3pazjdi 36 3 features feature NNS cord-252725-e3pazjdi 36 4 of of IN cord-252725-e3pazjdi 36 5 polyphenols polyphenol NNS cord-252725-e3pazjdi 36 6 as as IN cord-252725-e3pazjdi 36 7 a a DT cord-252725-e3pazjdi 36 8 natural natural JJ cord-252725-e3pazjdi 36 9 economical economical JJ cord-252725-e3pazjdi 36 10 , , , cord-252725-e3pazjdi 36 11 simple simple JJ cord-252725-e3pazjdi 36 12 and and CC cord-252725-e3pazjdi 36 13 environmental environmental JJ cord-252725-e3pazjdi 36 14 friendly friendly JJ cord-252725-e3pazjdi 36 15 compounds compound NNS cord-252725-e3pazjdi 36 16 warrant warrant VBP cord-252725-e3pazjdi 36 17 the the DT cord-252725-e3pazjdi 36 18 birth birth NN cord-252725-e3pazjdi 36 19 of of IN cord-252725-e3pazjdi 36 20 this this DT cord-252725-e3pazjdi 36 21 review review NN cord-252725-e3pazjdi 36 22 that that WDT cord-252725-e3pazjdi 36 23 highlights highlight VBZ cord-252725-e3pazjdi 36 24 the the DT cord-252725-e3pazjdi 36 25 current current JJ cord-252725-e3pazjdi 36 26 state state NN cord-252725-e3pazjdi 36 27 of of IN cord-252725-e3pazjdi 36 28 knowledge knowledge NN cord-252725-e3pazjdi 36 29 regarding regard VBG cord-252725-e3pazjdi 36 30 the the DT cord-252725-e3pazjdi 36 31 most most RBS cord-252725-e3pazjdi 36 32 important important JJ cord-252725-e3pazjdi 36 33 polyphenolic polyphenolic JJ cord-252725-e3pazjdi 36 34 compounds compound NNS cord-252725-e3pazjdi 36 35 [ [ -LRB- cord-252725-e3pazjdi 36 36 20 20 CD cord-252725-e3pazjdi 36 37 ] ] -RRB- cord-252725-e3pazjdi 36 38 , , , cord-252725-e3pazjdi 36 39 their -PRON- PRP$ cord-252725-e3pazjdi 36 40 relative relative JJ cord-252725-e3pazjdi 36 41 importance importance NN cord-252725-e3pazjdi 36 42 , , , cord-252725-e3pazjdi 36 43 their -PRON- PRP$ cord-252725-e3pazjdi 36 44 general general JJ cord-252725-e3pazjdi 36 45 properties property NNS cord-252725-e3pazjdi 36 46 in in IN cord-252725-e3pazjdi 36 47 human human JJ cord-252725-e3pazjdi 36 48 health health NN cord-252725-e3pazjdi 36 49 focusing focus VBG cord-252725-e3pazjdi 36 50 principally principally RB cord-252725-e3pazjdi 36 51 on on IN cord-252725-e3pazjdi 36 52 their -PRON- PRP$ cord-252725-e3pazjdi 36 53 antiviral antiviral JJ cord-252725-e3pazjdi 36 54 activities activity NNS cord-252725-e3pazjdi 36 55 , , , cord-252725-e3pazjdi 36 56 and and CC cord-252725-e3pazjdi 36 57 their -PRON- PRP$ cord-252725-e3pazjdi 36 58 role role NN cord-252725-e3pazjdi 36 59 in in IN cord-252725-e3pazjdi 36 60 enhancing enhance VBG cord-252725-e3pazjdi 36 61 immunity immunity NN cord-252725-e3pazjdi 36 62 in in IN cord-252725-e3pazjdi 36 63 order order NN cord-252725-e3pazjdi 36 64 to to TO cord-252725-e3pazjdi 36 65 face face VB cord-252725-e3pazjdi 36 66 the the DT cord-252725-e3pazjdi 36 67 emergence emergence NN cord-252725-e3pazjdi 36 68 of of IN cord-252725-e3pazjdi 36 69 several several JJ cord-252725-e3pazjdi 36 70 infectious infectious JJ cord-252725-e3pazjdi 36 71 diseases disease NNS cord-252725-e3pazjdi 36 72 such such JJ cord-252725-e3pazjdi 36 73 as as IN cord-252725-e3pazjdi 36 74 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 36 75 and and CC cord-252725-e3pazjdi 36 76 its -PRON- PRP$ cord-252725-e3pazjdi 36 77 related related JJ cord-252725-e3pazjdi 36 78 symptoms symptom NNS cord-252725-e3pazjdi 36 79 . . . cord-252725-e3pazjdi 37 1 Quercetin Quercetin NNS cord-252725-e3pazjdi 37 2 ( ( -LRB- cord-252725-e3pazjdi 37 3 3,3′,4′,5,7-pentahydroxyflavone 3,3′,4′,5,7-pentahydroxyflavone CD cord-252725-e3pazjdi 37 4 ) ) -RRB- cord-252725-e3pazjdi 37 5 ( ( -LRB- cord-252725-e3pazjdi 37 6 Fig Fig NNP cord-252725-e3pazjdi 37 7 . . NNP cord-252725-e3pazjdi 37 8 1 1 CD cord-252725-e3pazjdi 37 9 ) ) -RRB- cord-252725-e3pazjdi 37 10 , , , cord-252725-e3pazjdi 37 11 is be VBZ cord-252725-e3pazjdi 37 12 a a DT cord-252725-e3pazjdi 37 13 natural natural JJ cord-252725-e3pazjdi 37 14 plant plant NN cord-252725-e3pazjdi 37 15 flavonoid flavonoid NN cord-252725-e3pazjdi 37 16 involved involve VBN cord-252725-e3pazjdi 37 17 in in IN cord-252725-e3pazjdi 37 18 many many JJ cord-252725-e3pazjdi 37 19 plant plant NN cord-252725-e3pazjdi 37 20 processes process NNS cord-252725-e3pazjdi 37 21 such such JJ cord-252725-e3pazjdi 37 22 as as IN cord-252725-e3pazjdi 37 23 pigmentation pigmentation NN cord-252725-e3pazjdi 37 24 and and CC cord-252725-e3pazjdi 37 25 protection protection NN cord-252725-e3pazjdi 37 26 against against IN cord-252725-e3pazjdi 37 27 bacteria bacteria NNS cord-252725-e3pazjdi 37 28 and and CC cord-252725-e3pazjdi 37 29 fungi fungus NNS cord-252725-e3pazjdi 37 30 [ [ -LRB- cord-252725-e3pazjdi 37 31 21 21 CD cord-252725-e3pazjdi 37 32 ] ] -RRB- cord-252725-e3pazjdi 37 33 . . . cord-252725-e3pazjdi 38 1 Quercetin Quercetin NNS cord-252725-e3pazjdi 38 2 and and CC cord-252725-e3pazjdi 38 3 its -PRON- PRP$ cord-252725-e3pazjdi 38 4 glycosylated glycosylated JJ cord-252725-e3pazjdi 38 5 ( ( -LRB- cord-252725-e3pazjdi 38 6 quercetin-3-O quercetin-3-O NNP cord-252725-e3pazjdi 38 7 - - HYPH cord-252725-e3pazjdi 38 8 β β NN cord-252725-e3pazjdi 38 9 - - HYPH cord-252725-e3pazjdi 38 10 Dglucuronide Dglucuronide NNP cord-252725-e3pazjdi 38 11 ) ) -RRB- cord-252725-e3pazjdi 38 12 forms form NNS cord-252725-e3pazjdi 38 13 represent represent VBP cord-252725-e3pazjdi 38 14 60 60 CD cord-252725-e3pazjdi 38 15 - - SYM cord-252725-e3pazjdi 38 16 75 75 CD cord-252725-e3pazjdi 38 17 % % NN cord-252725-e3pazjdi 38 18 of of IN cord-252725-e3pazjdi 38 19 flavonoid flavonoid NN cord-252725-e3pazjdi 38 20 intake intake NN cord-252725-e3pazjdi 38 21 [ [ -LRB- cord-252725-e3pazjdi 38 22 22 22 CD cord-252725-e3pazjdi 38 23 ] ] -RRB- cord-252725-e3pazjdi 38 24 and and CC cord-252725-e3pazjdi 38 25 it -PRON- PRP cord-252725-e3pazjdi 38 26 has have VBZ cord-252725-e3pazjdi 38 27 been be VBN cord-252725-e3pazjdi 38 28 found find VBN cord-252725-e3pazjdi 38 29 ubiquitously ubiquitously RB cord-252725-e3pazjdi 38 30 in in IN cord-252725-e3pazjdi 38 31 many many JJ cord-252725-e3pazjdi 38 32 fruits fruit NNS cord-252725-e3pazjdi 38 33 and and CC cord-252725-e3pazjdi 38 34 vegetables vegetable NNS cord-252725-e3pazjdi 38 35 including include VBG cord-252725-e3pazjdi 38 36 apples apple NNS cord-252725-e3pazjdi 38 37 , , , cord-252725-e3pazjdi 38 38 berries berry NNS cord-252725-e3pazjdi 38 39 , , , cord-252725-e3pazjdi 38 40 brassica brassica NN cord-252725-e3pazjdi 38 41 vegetables vegetable NNS cord-252725-e3pazjdi 38 42 , , , cord-252725-e3pazjdi 38 43 capers caper NNS cord-252725-e3pazjdi 38 44 , , , cord-252725-e3pazjdi 38 45 grapes grape NNS cord-252725-e3pazjdi 38 46 , , , cord-252725-e3pazjdi 38 47 red red JJ cord-252725-e3pazjdi 38 48 onions onion NNS cord-252725-e3pazjdi 38 49 , , , cord-252725-e3pazjdi 38 50 shallots shallot NNS cord-252725-e3pazjdi 38 51 , , , cord-252725-e3pazjdi 38 52 kale kale NN cord-252725-e3pazjdi 38 53 , , , cord-252725-e3pazjdi 38 54 green green JJ cord-252725-e3pazjdi 38 55 tea tea NN cord-252725-e3pazjdi 38 56 , , , cord-252725-e3pazjdi 38 57 cranberries cranberry NNS cord-252725-e3pazjdi 38 58 , , , cord-252725-e3pazjdi 38 59 broccoli broccoli NN cord-252725-e3pazjdi 38 60 , , , cord-252725-e3pazjdi 38 61 tomatoes tomato NNS cord-252725-e3pazjdi 38 62 , , , cord-252725-e3pazjdi 38 63 nuts nut NNS cord-252725-e3pazjdi 38 64 , , , cord-252725-e3pazjdi 38 65 flowers flower NNS cord-252725-e3pazjdi 38 66 , , , cord-252725-e3pazjdi 38 67 barks bark NNS cord-252725-e3pazjdi 38 68 , , , cord-252725-e3pazjdi 38 69 leaves leave NNS cord-252725-e3pazjdi 38 70 and and CC cord-252725-e3pazjdi 38 71 honey honey NN cord-252725-e3pazjdi 38 72 [ [ -LRB- cord-252725-e3pazjdi 38 73 23 23 CD cord-252725-e3pazjdi 38 74 , , , cord-252725-e3pazjdi 38 75 24 24 CD cord-252725-e3pazjdi 38 76 ] ] -RRB- cord-252725-e3pazjdi 38 77 . . . cord-252725-e3pazjdi 39 1 Quercetin quercetin NN cord-252725-e3pazjdi 39 2 has have VBZ cord-252725-e3pazjdi 39 3 been be VBN cord-252725-e3pazjdi 39 4 known know VBN cord-252725-e3pazjdi 39 5 for for IN cord-252725-e3pazjdi 39 6 its -PRON- PRP$ cord-252725-e3pazjdi 39 7 antiviral antiviral JJ cord-252725-e3pazjdi 39 8 , , , cord-252725-e3pazjdi 39 9 anti anti JJ cord-252725-e3pazjdi 39 10 - - JJ cord-252725-e3pazjdi 39 11 inflammatory inflammatory JJ cord-252725-e3pazjdi 39 12 , , , cord-252725-e3pazjdi 39 13 anti anti JJ cord-252725-e3pazjdi 39 14 - - JJ cord-252725-e3pazjdi 39 15 carcinogenic carcinogenic JJ cord-252725-e3pazjdi 39 16 and and CC cord-252725-e3pazjdi 39 17 antioxidant antioxidant JJ cord-252725-e3pazjdi 39 18 properties property NNS cord-252725-e3pazjdi 39 19 [ [ -LRB- cord-252725-e3pazjdi 39 20 25 25 CD cord-252725-e3pazjdi 39 21 ] ] -RRB- cord-252725-e3pazjdi 39 22 as as RB cord-252725-e3pazjdi 39 23 well well RB cord-252725-e3pazjdi 39 24 as as IN cord-252725-e3pazjdi 39 25 its -PRON- PRP$ cord-252725-e3pazjdi 39 26 exceptional exceptional JJ cord-252725-e3pazjdi 39 27 ability ability NN cord-252725-e3pazjdi 39 28 to to TO cord-252725-e3pazjdi 39 29 improve improve VB cord-252725-e3pazjdi 39 30 mental mental JJ cord-252725-e3pazjdi 39 31 and and CC cord-252725-e3pazjdi 39 32 physical physical JJ cord-252725-e3pazjdi 39 33 activities activity NNS cord-252725-e3pazjdi 39 34 and and CC cord-252725-e3pazjdi 39 35 decrease decrease VB cord-252725-e3pazjdi 39 36 infection infection NN cord-252725-e3pazjdi 39 37 risk risk NN cord-252725-e3pazjdi 39 38 [ [ -LRB- cord-252725-e3pazjdi 39 39 26 26 CD cord-252725-e3pazjdi 39 40 ] ] -RRB- cord-252725-e3pazjdi 39 41 . . . cord-252725-e3pazjdi 40 1 In in IN cord-252725-e3pazjdi 40 2 fact fact NN cord-252725-e3pazjdi 40 3 , , , cord-252725-e3pazjdi 40 4 quercetin quercetin NNP cord-252725-e3pazjdi 40 5 is be VBZ cord-252725-e3pazjdi 40 6 considered consider VBN cord-252725-e3pazjdi 40 7 as as IN cord-252725-e3pazjdi 40 8 a a DT cord-252725-e3pazjdi 40 9 strong strong JJ cord-252725-e3pazjdi 40 10 anti anti JJ cord-252725-e3pazjdi 40 11 - - JJ cord-252725-e3pazjdi 40 12 oxidant oxidant JJ cord-252725-e3pazjdi 40 13 due due IN cord-252725-e3pazjdi 40 14 to to IN cord-252725-e3pazjdi 40 15 its -PRON- PRP$ cord-252725-e3pazjdi 40 16 ability ability NN cord-252725-e3pazjdi 40 17 to to TO cord-252725-e3pazjdi 40 18 inhibit inhibit VB cord-252725-e3pazjdi 40 19 lipid lipid NN cord-252725-e3pazjdi 40 20 peroxidation peroxidation NN cord-252725-e3pazjdi 40 21 and and CC cord-252725-e3pazjdi 40 22 thus thus RB cord-252725-e3pazjdi 40 23 it -PRON- PRP cord-252725-e3pazjdi 40 24 protects protect VBZ cord-252725-e3pazjdi 40 25 many many JJ cord-252725-e3pazjdi 40 26 body body NN cord-252725-e3pazjdi 40 27 organs organ NNS cord-252725-e3pazjdi 40 28 from from IN cord-252725-e3pazjdi 40 29 harmful harmful JJ cord-252725-e3pazjdi 40 30 effects effect NNS cord-252725-e3pazjdi 40 31 of of IN cord-252725-e3pazjdi 40 32 the the DT cord-252725-e3pazjdi 40 33 consequential consequential JJ cord-252725-e3pazjdi 40 34 free free JJ cord-252725-e3pazjdi 40 35 radicals radical NNS cord-252725-e3pazjdi 40 36 [ [ -LRB- cord-252725-e3pazjdi 40 37 27 27 CD cord-252725-e3pazjdi 40 38 , , , cord-252725-e3pazjdi 40 39 28 28 CD cord-252725-e3pazjdi 40 40 ] ] -RRB- cord-252725-e3pazjdi 40 41 . . . cord-252725-e3pazjdi 41 1 In in IN cord-252725-e3pazjdi 41 2 addition addition NN cord-252725-e3pazjdi 41 3 , , , cord-252725-e3pazjdi 41 4 the the DT cord-252725-e3pazjdi 41 5 general general JJ cord-252725-e3pazjdi 41 6 mechanism mechanism NN cord-252725-e3pazjdi 41 7 by by IN cord-252725-e3pazjdi 41 8 which which WDT cord-252725-e3pazjdi 41 9 quercetin quercetin NN cord-252725-e3pazjdi 41 10 exerts exert VBZ cord-252725-e3pazjdi 41 11 its -PRON- PRP$ cord-252725-e3pazjdi 41 12 antiinflammatory antiinflammatory JJ cord-252725-e3pazjdi 41 13 effects effect NNS cord-252725-e3pazjdi 41 14 is be VBZ cord-252725-e3pazjdi 41 15 believed believe VBN cord-252725-e3pazjdi 41 16 to to TO cord-252725-e3pazjdi 41 17 be be VB cord-252725-e3pazjdi 41 18 due due JJ cord-252725-e3pazjdi 41 19 to to IN cord-252725-e3pazjdi 41 20 its -PRON- PRP$ cord-252725-e3pazjdi 41 21 ability ability NN cord-252725-e3pazjdi 41 22 to to TO cord-252725-e3pazjdi 41 23 restrain restrain VB cord-252725-e3pazjdi 41 24 COX-2 COX-2 NNP cord-252725-e3pazjdi 41 25 and and CC cord-252725-e3pazjdi 41 26 iNOS inos JJ cord-252725-e3pazjdi 41 27 , , , cord-252725-e3pazjdi 41 28 NF NF NNP cord-252725-e3pazjdi 41 29 - - HYPH cord-252725-e3pazjdi 41 30 κB κB NNP cord-252725-e3pazjdi 41 31 , , , cord-252725-e3pazjdi 41 32 activator activator NN cord-252725-e3pazjdi 41 33 protein-1 protein-1 NNP cord-252725-e3pazjdi 41 34 ( ( -LRB- cord-252725-e3pazjdi 41 35 AP-1 AP-1 NNP cord-252725-e3pazjdi 41 36 ) ) -RRB- cord-252725-e3pazjdi 41 37 , , , cord-252725-e3pazjdi 41 38 and and CC cord-252725-e3pazjdi 41 39 mitogen mitogen NN cord-252725-e3pazjdi 41 40 - - HYPH cord-252725-e3pazjdi 41 41 activated activate VBN cord-252725-e3pazjdi 41 42 protein protein NN cord-252725-e3pazjdi 41 43 kinase kinase NN cord-252725-e3pazjdi 41 44 ( ( -LRB- cord-252725-e3pazjdi 41 45 MAPK MAPK NNP cord-252725-e3pazjdi 41 46 ) ) -RRB- cord-252725-e3pazjdi 41 47 usually usually RB cord-252725-e3pazjdi 41 48 , , , cord-252725-e3pazjdi 41 49 associated associate VBN cord-252725-e3pazjdi 41 50 with with IN cord-252725-e3pazjdi 41 51 the the DT cord-252725-e3pazjdi 41 52 inflammatory inflammatory JJ cord-252725-e3pazjdi 41 53 response response NN cord-252725-e3pazjdi 41 54 during during IN cord-252725-e3pazjdi 41 55 infections infection NNS cord-252725-e3pazjdi 41 56 . . . cord-252725-e3pazjdi 42 1 Subsequently subsequently RB cord-252725-e3pazjdi 42 2 , , , cord-252725-e3pazjdi 42 3 inhibiting inhibit VBG cord-252725-e3pazjdi 42 4 the the DT cord-252725-e3pazjdi 42 5 production production NN cord-252725-e3pazjdi 42 6 of of IN cord-252725-e3pazjdi 42 7 pro pro JJ cord-252725-e3pazjdi 42 8 - - JJ cord-252725-e3pazjdi 42 9 inflammatory inflammatory JJ cord-252725-e3pazjdi 42 10 markers marker NNS cord-252725-e3pazjdi 42 11 and and CC cord-252725-e3pazjdi 42 12 cytokines cytokine NNS cord-252725-e3pazjdi 42 13 ( ( -LRB- cord-252725-e3pazjdi 42 14 IL-1β IL-1β NNP cord-252725-e3pazjdi 42 15 , , , cord-252725-e3pazjdi 42 16 IL-6 IL-6 NNP cord-252725-e3pazjdi 42 17 , , , cord-252725-e3pazjdi 42 18 IFN IFN NNP cord-252725-e3pazjdi 42 19 - - HYPH cord-252725-e3pazjdi 42 20 γ γ NNP cord-252725-e3pazjdi 42 21 , , , cord-252725-e3pazjdi 42 22 TNF TNF NNP cord-252725-e3pazjdi 42 23 - - HYPH cord-252725-e3pazjdi 42 24 α α NNP cord-252725-e3pazjdi 42 25 , , , cord-252725-e3pazjdi 42 26 monocyte monocyte NNP cord-252725-e3pazjdi 42 27 chemoattractant chemoattractant NNP cord-252725-e3pazjdi 42 28 protein-1 protein-1 NNP cord-252725-e3pazjdi 42 29 : : : cord-252725-e3pazjdi 42 30 MCP-1 MCP-1 NNP cord-252725-e3pazjdi 42 31 , , , cord-252725-e3pazjdi 42 32 lipoxygenase lipoxygenase NN cord-252725-e3pazjdi 42 33 : : : cord-252725-e3pazjdi 42 34 LOX LOX NNP cord-252725-e3pazjdi 42 35 ) ) -RRB- cord-252725-e3pazjdi 42 36 and and CC cord-252725-e3pazjdi 42 37 thus thus RB cord-252725-e3pazjdi 42 38 enhancing enhance VBG cord-252725-e3pazjdi 42 39 the the DT cord-252725-e3pazjdi 42 40 antiinflammatory antiinflammatory JJ cord-252725-e3pazjdi 42 41 cytokines cytokine NNS cord-252725-e3pazjdi 42 42 like like IN cord-252725-e3pazjdi 42 43 IL10 IL10 NNP cord-252725-e3pazjdi 42 44 [ [ -LRB- cord-252725-e3pazjdi 42 45 29 29 CD cord-252725-e3pazjdi 42 46 ] ] -RRB- cord-252725-e3pazjdi 42 47 . . . cord-252725-e3pazjdi 43 1 Moreover moreover RB cord-252725-e3pazjdi 43 2 , , , cord-252725-e3pazjdi 43 3 a a DT cord-252725-e3pazjdi 43 4 study study NN cord-252725-e3pazjdi 43 5 demonstrated demonstrate VBD cord-252725-e3pazjdi 43 6 that that IN cord-252725-e3pazjdi 43 7 both both CC cord-252725-e3pazjdi 43 8 quercetin quercetin NN cord-252725-e3pazjdi 43 9 and and CC cord-252725-e3pazjdi 43 10 quercitrin quercitrin NNP cord-252725-e3pazjdi 43 11 could could MD cord-252725-e3pazjdi 43 12 inhibit inhibit VB cord-252725-e3pazjdi 43 13 LPS LPS NNP cord-252725-e3pazjdi 43 14 - - HYPH cord-252725-e3pazjdi 43 15 induced induce VBN cord-252725-e3pazjdi 43 16 macrophage macrophage NN cord-252725-e3pazjdi 43 17 inflammation inflammation NN cord-252725-e3pazjdi 43 18 and and CC cord-252725-e3pazjdi 43 19 oxidative oxidative JJ cord-252725-e3pazjdi 43 20 stress stress NN cord-252725-e3pazjdi 43 21 by by IN cord-252725-e3pazjdi 43 22 experiment experiment NN cord-252725-e3pazjdi 43 23 and and CC cord-252725-e3pazjdi 43 24 theoretical theoretical JJ cord-252725-e3pazjdi 43 25 calculations calculation NNS cord-252725-e3pazjdi 43 26 [ [ -LRB- cord-252725-e3pazjdi 43 27 30 30 CD cord-252725-e3pazjdi 43 28 ] ] -RRB- cord-252725-e3pazjdi 43 29 . . . cord-252725-e3pazjdi 44 1 Quercetin quercetin NN cord-252725-e3pazjdi 44 2 blocks block NNS cord-252725-e3pazjdi 44 3 in in IN cord-252725-e3pazjdi 44 4 vitro vitro FW cord-252725-e3pazjdi 44 5 TNFα TNFα NNS cord-252725-e3pazjdi 44 6 - - HYPH cord-252725-e3pazjdi 44 7 mediated mediate VBN cord-252725-e3pazjdi 44 8 inflammation inflammation NN cord-252725-e3pazjdi 44 9 which which WDT cord-252725-e3pazjdi 44 10 prevents prevent VBZ cord-252725-e3pazjdi 44 11 TNF TNF NNP cord-252725-e3pazjdi 44 12 - - HYPH cord-252725-e3pazjdi 44 13 α α NN cord-252725-e3pazjdi 44 14 from from IN cord-252725-e3pazjdi 44 15 directly directly RB cord-252725-e3pazjdi 44 16 activating activate VBG cord-252725-e3pazjdi 44 17 extracellular extracellular JJ cord-252725-e3pazjdi 44 18 signal signal NN cord-252725-e3pazjdi 44 19 - - HYPH cord-252725-e3pazjdi 44 20 related relate VBN cord-252725-e3pazjdi 44 21 kinase kinase NN cord-252725-e3pazjdi 44 22 ( ( -LRB- cord-252725-e3pazjdi 44 23 ERK ERK NNP cord-252725-e3pazjdi 44 24 ) ) -RRB- cord-252725-e3pazjdi 44 25 , , , cord-252725-e3pazjdi 44 26 c c LS cord-252725-e3pazjdi 44 27 - - : cord-252725-e3pazjdi 44 28 Jun Jun NNP cord-252725-e3pazjdi 44 29 NH2-terminal nh2-terminal NN cord-252725-e3pazjdi 44 30 kinase kinase NN cord-252725-e3pazjdi 44 31 ( ( -LRB- cord-252725-e3pazjdi 44 32 JNK JNK NNP cord-252725-e3pazjdi 44 33 ) ) -RRB- cord-252725-e3pazjdi 44 34 , , , cord-252725-e3pazjdi 44 35 c c LS cord-252725-e3pazjdi 44 36 - - : cord-252725-e3pazjdi 44 37 Jun Jun NNP cord-252725-e3pazjdi 44 38 , , , cord-252725-e3pazjdi 44 39 and and CC cord-252725-e3pazjdi 44 40 NF NF NNP cord-252725-e3pazjdi 44 41 - - HYPH cord-252725-e3pazjdi 44 42 κB κB NNP cord-252725-e3pazjdi 44 43 , , , cord-252725-e3pazjdi 44 44 which which WDT cord-252725-e3pazjdi 44 45 are be VBP cord-252725-e3pazjdi 44 46 well well RB cord-252725-e3pazjdi 44 47 known know VBN cord-252725-e3pazjdi 44 48 potent potent JJ cord-252725-e3pazjdi 44 49 inducers inducer NNS cord-252725-e3pazjdi 44 50 of of IN cord-252725-e3pazjdi 44 51 inflammatory inflammatory JJ cord-252725-e3pazjdi 44 52 gene gene NN cord-252725-e3pazjdi 44 53 expression expression NN cord-252725-e3pazjdi 44 54 and and CC cord-252725-e3pazjdi 44 55 protein protein NN cord-252725-e3pazjdi 44 56 secretion secretion NN cord-252725-e3pazjdi 44 57 . . . cord-252725-e3pazjdi 45 1 Quercetin Quercetin NNS cord-252725-e3pazjdi 45 2 can can MD cord-252725-e3pazjdi 45 3 also also RB cord-252725-e3pazjdi 45 4 indirectly indirectly RB cord-252725-e3pazjdi 45 5 inhibit inhibit VB cord-252725-e3pazjdi 45 6 the the DT cord-252725-e3pazjdi 45 7 inflammatory inflammatory JJ cord-252725-e3pazjdi 45 8 process process NN cord-252725-e3pazjdi 45 9 by by IN cord-252725-e3pazjdi 45 10 increasing increase VBG cord-252725-e3pazjdi 45 11 peroxisome peroxisome NN cord-252725-e3pazjdi 45 12 proliferator proliferator NN cord-252725-e3pazjdi 45 13 - - HYPH cord-252725-e3pazjdi 45 14 activated activate VBN cord-252725-e3pazjdi 45 15 receptor receptor NN cord-252725-e3pazjdi 45 16 c c NN cord-252725-e3pazjdi 45 17 ( ( -LRB- cord-252725-e3pazjdi 45 18 PPARγ PPARγ NNPS cord-252725-e3pazjdi 45 19 ) ) -RRB- cord-252725-e3pazjdi 45 20 which which WDT cord-252725-e3pazjdi 45 21 is be VBZ cord-252725-e3pazjdi 45 22 antagonized antagonize VBN cord-252725-e3pazjdi 45 23 NF NF NNP cord-252725-e3pazjdi 45 24 - - HYPH cord-252725-e3pazjdi 45 25 kB kB NNP cord-252725-e3pazjdi 45 26 and and CC cord-252725-e3pazjdi 45 27 AP-1 AP-1 NNP cord-252725-e3pazjdi 45 28 thus thus RB cord-252725-e3pazjdi 45 29 inhibiting inhibit VBG cord-252725-e3pazjdi 45 30 the the DT cord-252725-e3pazjdi 45 31 inflammatory inflammatory JJ cord-252725-e3pazjdi 45 32 cascades cascade NNS cord-252725-e3pazjdi 45 33 and and CC cord-252725-e3pazjdi 45 34 subsequently subsequently RB cord-252725-e3pazjdi 45 35 decreases decrease VBZ cord-252725-e3pazjdi 45 36 the the DT cord-252725-e3pazjdi 45 37 expression expression NN cord-252725-e3pazjdi 45 38 of of IN cord-252725-e3pazjdi 45 39 the the DT cord-252725-e3pazjdi 45 40 inflammatory inflammatory JJ cord-252725-e3pazjdi 45 41 genes gene NNS cord-252725-e3pazjdi 45 42 [ [ -LRB- cord-252725-e3pazjdi 45 43 31 31 CD cord-252725-e3pazjdi 45 44 ] ] -RRB- cord-252725-e3pazjdi 45 45 . . . cord-252725-e3pazjdi 46 1 Quercetin quercetin NN cord-252725-e3pazjdi 46 2 has have VBZ cord-252725-e3pazjdi 46 3 also also RB cord-252725-e3pazjdi 46 4 beneficial beneficial JJ cord-252725-e3pazjdi 46 5 immuno immuno JJ cord-252725-e3pazjdi 46 6 - - HYPH cord-252725-e3pazjdi 46 7 stimulatory stimulatory JJ cord-252725-e3pazjdi 46 8 effects effect NNS cord-252725-e3pazjdi 46 9 by by IN cord-252725-e3pazjdi 46 10 inducing induce VBG cord-252725-e3pazjdi 46 11 the the DT cord-252725-e3pazjdi 46 12 expression expression NN cord-252725-e3pazjdi 46 13 of of IN cord-252725-e3pazjdi 46 14 several several JJ cord-252725-e3pazjdi 46 15 vital vital JJ cord-252725-e3pazjdi 46 16 genes gene NNS cord-252725-e3pazjdi 46 17 and and CC cord-252725-e3pazjdi 46 18 the the DT cord-252725-e3pazjdi 46 19 production production NN cord-252725-e3pazjdi 46 20 of of IN cord-252725-e3pazjdi 46 21 Th-1 Th-1 NNP cord-252725-e3pazjdi 46 22 derived derive VBD cord-252725-e3pazjdi 46 23 IFN IFN NNP cord-252725-e3pazjdi 46 24 - - HYPH cord-252725-e3pazjdi 46 25 γ γ NN cord-252725-e3pazjdi 46 26 and and CC cord-252725-e3pazjdi 46 27 down down RB cord-252725-e3pazjdi 46 28 - - HYPH cord-252725-e3pazjdi 46 29 regulating regulate VBG cord-252725-e3pazjdi 46 30 Th-2 Th-2 NNP cord-252725-e3pazjdi 46 31 derived derive VBD cord-252725-e3pazjdi 46 32 interleukin interleukin NN cord-252725-e3pazjdi 46 33 4 4 CD cord-252725-e3pazjdi 46 34 ( ( -LRB- cord-252725-e3pazjdi 46 35 IL-4 IL-4 NNP cord-252725-e3pazjdi 46 36 ) ) -RRB- cord-252725-e3pazjdi 46 37 . . . cord-252725-e3pazjdi 47 1 In in IN cord-252725-e3pazjdi 47 2 fact fact NN cord-252725-e3pazjdi 47 3 , , , cord-252725-e3pazjdi 47 4 quercetin quercetin JJ cord-252725-e3pazjdi 47 5 is be VBZ cord-252725-e3pazjdi 47 6 seen see VBN cord-252725-e3pazjdi 47 7 as as IN cord-252725-e3pazjdi 47 8 a a DT cord-252725-e3pazjdi 47 9 universal universal JJ cord-252725-e3pazjdi 47 10 suppressor suppressor NN cord-252725-e3pazjdi 47 11 of of IN cord-252725-e3pazjdi 47 12 the the DT cord-252725-e3pazjdi 47 13 accumulation accumulation NN cord-252725-e3pazjdi 47 14 and and CC cord-252725-e3pazjdi 47 15 activation activation NN cord-252725-e3pazjdi 47 16 of of IN cord-252725-e3pazjdi 47 17 immune immune JJ cord-252725-e3pazjdi 47 18 cells cell NNS cord-252725-e3pazjdi 47 19 , , , cord-252725-e3pazjdi 47 20 which which WDT cord-252725-e3pazjdi 47 21 prevents prevent VBZ cord-252725-e3pazjdi 47 22 chronic chronic JJ cord-252725-e3pazjdi 47 23 inflammation inflammation NN cord-252725-e3pazjdi 47 24 [ [ -LRB- cord-252725-e3pazjdi 47 25 31 31 CD cord-252725-e3pazjdi 47 26 , , , cord-252725-e3pazjdi 47 27 32 32 CD cord-252725-e3pazjdi 47 28 ] ] -RRB- cord-252725-e3pazjdi 47 29 . . . cord-252725-e3pazjdi 48 1 Quercetin quercetin NN cord-252725-e3pazjdi 48 2 relaxes relax VBZ cord-252725-e3pazjdi 48 3 airway airway NN cord-252725-e3pazjdi 48 4 smooth smooth JJ cord-252725-e3pazjdi 48 5 muscle muscle NN cord-252725-e3pazjdi 48 6 and and CC cord-252725-e3pazjdi 48 7 potentiates potentiate VBZ cord-252725-e3pazjdi 48 8 β β NN cord-252725-e3pazjdi 48 9 - - HYPH cord-252725-e3pazjdi 48 10 agonist agonist NN cord-252725-e3pazjdi 48 11 - - HYPH cord-252725-e3pazjdi 48 12 induced induce VBN cord-252725-e3pazjdi 48 13 relaxation relaxation NN cord-252725-e3pazjdi 48 14 via via IN cord-252725-e3pazjdi 48 15 dual dual JJ cord-252725-e3pazjdi 48 16 phosphodiesterase phosphodiesterase NN cord-252725-e3pazjdi 48 17 inhibition inhibition NN cord-252725-e3pazjdi 48 18 of of IN cord-252725-e3pazjdi 48 19 purified purify VBN cord-252725-e3pazjdi 48 20 phosphatidylinositol phosphatidylinositol JJ cord-252725-e3pazjdi 48 21 - - HYPH cord-252725-e3pazjdi 48 22 specific specific JJ cord-252725-e3pazjdi 48 23 phospholipase phospholipase NN cord-252725-e3pazjdi 48 24 ( ( -LRB- cord-252725-e3pazjdi 48 25 CPLCβ CPLCβ NNS cord-252725-e3pazjdi 48 26 ) ) -RRB- cord-252725-e3pazjdi 48 27 and and CC cord-252725-e3pazjdi 49 1 phosphodiesterase phosphodiesterase NNP cord-252725-e3pazjdi 49 2 type type NN cord-252725-e3pazjdi 49 3 4 4 CD cord-252725-e3pazjdi 49 4 inhibitor inhibitor NN cord-252725-e3pazjdi 49 5 ( ( -LRB- cord-252725-e3pazjdi 49 6 PDE4 PDE4 NNP cord-252725-e3pazjdi 49 7 ) ) -RRB- cord-252725-e3pazjdi 49 8 [ [ -LRB- cord-252725-e3pazjdi 49 9 33 33 CD cord-252725-e3pazjdi 49 10 ] ] -RRB- cord-252725-e3pazjdi 49 11 . . . cord-252725-e3pazjdi 50 1 Quercetin Quercetin NNS cord-252725-e3pazjdi 50 2 has have VBZ cord-252725-e3pazjdi 50 3 exerted exert VBN cord-252725-e3pazjdi 50 4 strong strong JJ cord-252725-e3pazjdi 50 5 anti anti JJ cord-252725-e3pazjdi 50 6 - - JJ cord-252725-e3pazjdi 50 7 pathogenic pathogenic JJ cord-252725-e3pazjdi 50 8 effects effect NNS cord-252725-e3pazjdi 50 9 against against IN cord-252725-e3pazjdi 50 10 several several JJ cord-252725-e3pazjdi 50 11 causal causal JJ cord-252725-e3pazjdi 50 12 agents agent NNS cord-252725-e3pazjdi 50 13 of of IN cord-252725-e3pazjdi 50 14 upper upper JJ cord-252725-e3pazjdi 50 15 respiratory respiratory JJ cord-252725-e3pazjdi 50 16 tract tract NN cord-252725-e3pazjdi 50 17 infection infection NN cord-252725-e3pazjdi 50 18 in in IN cord-252725-e3pazjdi 50 19 vitro vitro FW cord-252725-e3pazjdi 50 20 studies study NNS cord-252725-e3pazjdi 50 21 [ [ -LRB- cord-252725-e3pazjdi 50 22 34 34 CD cord-252725-e3pazjdi 50 23 ] ] -RRB- cord-252725-e3pazjdi 50 24 . . . cord-252725-e3pazjdi 51 1 Quercetin quercetin NN cord-252725-e3pazjdi 51 2 inverted inverted JJ cord-252725-e3pazjdi 51 3 lung lung NN cord-252725-e3pazjdi 51 4 fibrosing fibrose VBG cord-252725-e3pazjdi 51 5 in in IN cord-252725-e3pazjdi 51 6 mice mouse NNS cord-252725-e3pazjdi 51 7 and and CC cord-252725-e3pazjdi 51 8 reversed reverse VBD cord-252725-e3pazjdi 51 9 the the DT cord-252725-e3pazjdi 51 10 disease disease NN cord-252725-e3pazjdi 51 11 progression progression NN cord-252725-e3pazjdi 51 12 normally normally RB cord-252725-e3pazjdi 51 13 caused cause VBN cord-252725-e3pazjdi 51 14 by by IN cord-252725-e3pazjdi 51 15 usual usual JJ cord-252725-e3pazjdi 51 16 pulmonary pulmonary JJ cord-252725-e3pazjdi 51 17 aging aging NN cord-252725-e3pazjdi 51 18 markers marker NNS cord-252725-e3pazjdi 51 19 [ [ -LRB- cord-252725-e3pazjdi 51 20 34 34 CD cord-252725-e3pazjdi 51 21 ] ] -RRB- cord-252725-e3pazjdi 51 22 . . . cord-252725-e3pazjdi 52 1 Moreover moreover RB cord-252725-e3pazjdi 52 2 , , , cord-252725-e3pazjdi 52 3 it -PRON- PRP cord-252725-e3pazjdi 52 4 was be VBD cord-252725-e3pazjdi 52 5 found find VBN cord-252725-e3pazjdi 52 6 to to TO cord-252725-e3pazjdi 52 7 reduce reduce VB cord-252725-e3pazjdi 52 8 the the DT cord-252725-e3pazjdi 52 9 reactive reactive JJ cord-252725-e3pazjdi 52 10 oxygenated oxygenated JJ cord-252725-e3pazjdi 52 11 species specie NNS cord-252725-e3pazjdi 52 12 ( ( -LRB- cord-252725-e3pazjdi 52 13 ROS ROS NNP cord-252725-e3pazjdi 52 14 ) ) -RRB- cord-252725-e3pazjdi 52 15 produced produce VBN cord-252725-e3pazjdi 52 16 during during IN cord-252725-e3pazjdi 52 17 viral viral JJ cord-252725-e3pazjdi 52 18 infection infection NN cord-252725-e3pazjdi 52 19 and and CC cord-252725-e3pazjdi 52 20 subsequently subsequently RB cord-252725-e3pazjdi 52 21 decrease decrease VB cord-252725-e3pazjdi 52 22 pro pro JJ cord-252725-e3pazjdi 52 23 - - JJ cord-252725-e3pazjdi 52 24 inflammatory inflammatory JJ cord-252725-e3pazjdi 52 25 markers marker NNS cord-252725-e3pazjdi 52 26 such such JJ cord-252725-e3pazjdi 52 27 as as IN cord-252725-e3pazjdi 52 28 IL-8 IL-8 NNP cord-252725-e3pazjdi 52 29 , , , cord-252725-e3pazjdi 52 30 TNF TNF NNP cord-252725-e3pazjdi 52 31 - - HYPH cord-252725-e3pazjdi 52 32 α α NNP cord-252725-e3pazjdi 52 33 , , , cord-252725-e3pazjdi 52 34 IL-1β IL-1β NNP cord-252725-e3pazjdi 52 35 and and CC cord-252725-e3pazjdi 52 36 IL-6 IL-6 NNP cord-252725-e3pazjdi 52 37 [ [ -LRB- cord-252725-e3pazjdi 52 38 25 25 CD cord-252725-e3pazjdi 52 39 ] ] -RRB- cord-252725-e3pazjdi 52 40 and and CC cord-252725-e3pazjdi 52 41 increases increase VBZ cord-252725-e3pazjdi 52 42 anti anti JJ cord-252725-e3pazjdi 52 43 - - JJ cord-252725-e3pazjdi 52 44 inflammatory inflammatory JJ cord-252725-e3pazjdi 52 45 cytokines cytokine NNS cord-252725-e3pazjdi 52 46 such such JJ cord-252725-e3pazjdi 52 47 as as IN cord-252725-e3pazjdi 52 48 IL-10 IL-10 NNP cord-252725-e3pazjdi 52 49 [ [ -LRB- cord-252725-e3pazjdi 52 50 35 35 CD cord-252725-e3pazjdi 52 51 ] ] -RRB- cord-252725-e3pazjdi 52 52 , , , cord-252725-e3pazjdi 52 53 indicating indicate VBG cord-252725-e3pazjdi 52 54 that that IN cord-252725-e3pazjdi 52 55 it -PRON- PRP cord-252725-e3pazjdi 52 56 has have VBZ cord-252725-e3pazjdi 52 57 clear clear JJ cord-252725-e3pazjdi 52 58 antiviral antiviral JJ cord-252725-e3pazjdi 52 59 effects effect NNS cord-252725-e3pazjdi 52 60 on on IN cord-252725-e3pazjdi 52 61 several several JJ cord-252725-e3pazjdi 52 62 respiratory respiratory JJ cord-252725-e3pazjdi 52 63 and and CC cord-252725-e3pazjdi 52 64 common common JJ cord-252725-e3pazjdi 52 65 cold cold JJ cord-252725-e3pazjdi 52 66 viruses virus NNS cord-252725-e3pazjdi 52 67 through through IN cord-252725-e3pazjdi 52 68 its -PRON- PRP$ cord-252725-e3pazjdi 52 69 ability ability NN cord-252725-e3pazjdi 52 70 to to TO cord-252725-e3pazjdi 52 71 reduce reduce VB cord-252725-e3pazjdi 52 72 virus virus NN cord-252725-e3pazjdi 52 73 imputation imputation NN cord-252725-e3pazjdi 52 74 , , , cord-252725-e3pazjdi 52 75 replication replication NN cord-252725-e3pazjdi 52 76 and and CC cord-252725-e3pazjdi 52 77 viral viral JJ cord-252725-e3pazjdi 52 78 load load NN cord-252725-e3pazjdi 52 79 in in IN cord-252725-e3pazjdi 52 80 vitro vitro FW cord-252725-e3pazjdi 52 81 , , , cord-252725-e3pazjdi 52 82 as as RB cord-252725-e3pazjdi 52 83 well well RB cord-252725-e3pazjdi 52 84 as as IN cord-252725-e3pazjdi 52 85 lung lung NN cord-252725-e3pazjdi 52 86 inflammation inflammation NN cord-252725-e3pazjdi 52 87 and and CC cord-252725-e3pazjdi 52 88 airways airway NNS cord-252725-e3pazjdi 52 89 hyper hyper NN cord-252725-e3pazjdi 52 90 - - NN cord-252725-e3pazjdi 52 91 responsiveness responsiveness NN cord-252725-e3pazjdi 52 92 in in IN cord-252725-e3pazjdi 52 93 vivo vivo NNP cord-252725-e3pazjdi 52 94 [ [ -LRB- cord-252725-e3pazjdi 52 95 29 29 CD cord-252725-e3pazjdi 52 96 ] ] -RRB- cord-252725-e3pazjdi 52 97 . . . cord-252725-e3pazjdi 53 1 Quercetin quercetin NN cord-252725-e3pazjdi 53 2 was be VBD cord-252725-e3pazjdi 53 3 found find VBN cord-252725-e3pazjdi 53 4 to to TO cord-252725-e3pazjdi 53 5 be be VB cord-252725-e3pazjdi 53 6 a a DT cord-252725-e3pazjdi 53 7 strong strong JJ cord-252725-e3pazjdi 53 8 inhibitor inhibitor NN cord-252725-e3pazjdi 53 9 of of IN cord-252725-e3pazjdi 53 10 influenza influenza NN cord-252725-e3pazjdi 53 11 A a DT cord-252725-e3pazjdi 53 12 virus virus NN cord-252725-e3pazjdi 53 13 in in IN cord-252725-e3pazjdi 53 14 the the DT cord-252725-e3pazjdi 53 15 early early JJ cord-252725-e3pazjdi 53 16 stage stage NN cord-252725-e3pazjdi 53 17 of of IN cord-252725-e3pazjdi 53 18 infection infection NN cord-252725-e3pazjdi 53 19 [ [ -LRB- cord-252725-e3pazjdi 53 20 36 36 CD cord-252725-e3pazjdi 53 21 ] ] -RRB- cord-252725-e3pazjdi 53 22 and and CC cord-252725-e3pazjdi 53 23 demonstrated demonstrate VBD cord-252725-e3pazjdi 53 24 significant significant JJ cord-252725-e3pazjdi 53 25 inhibitory inhibitory JJ cord-252725-e3pazjdi 53 26 activities activity NNS cord-252725-e3pazjdi 53 27 against against IN cord-252725-e3pazjdi 53 28 dengue dengue NN cord-252725-e3pazjdi 53 29 virus virus NN cord-252725-e3pazjdi 53 30 type-2 type-2 NN cord-252725-e3pazjdi 53 31 but but CC cord-252725-e3pazjdi 53 32 the the DT cord-252725-e3pazjdi 53 33 mechanisms mechanism NNS cord-252725-e3pazjdi 53 34 of of IN cord-252725-e3pazjdi 53 35 how how WRB cord-252725-e3pazjdi 53 36 quercetin quercetin NN cord-252725-e3pazjdi 53 37 exerts exert VBZ cord-252725-e3pazjdi 53 38 its -PRON- PRP$ cord-252725-e3pazjdi 53 39 antiviral antiviral JJ cord-252725-e3pazjdi 53 40 effects effect NNS cord-252725-e3pazjdi 53 41 are be VBP cord-252725-e3pazjdi 53 42 not not RB cord-252725-e3pazjdi 53 43 fully fully RB cord-252725-e3pazjdi 53 44 understood understand VBN cord-252725-e3pazjdi 53 45 [ [ -LRB- cord-252725-e3pazjdi 53 46 37 37 CD cord-252725-e3pazjdi 53 47 ] ] -RRB- cord-252725-e3pazjdi 53 48 . . . cord-252725-e3pazjdi 54 1 Quercetin quercetin NN cord-252725-e3pazjdi 54 2 prevented prevent VBD cord-252725-e3pazjdi 54 3 rhinovirusinduced rhinovirusinduced JJ cord-252725-e3pazjdi 54 4 progression progression NN cord-252725-e3pazjdi 54 5 of of IN cord-252725-e3pazjdi 54 6 lung lung NN cord-252725-e3pazjdi 54 7 disease disease NN cord-252725-e3pazjdi 54 8 in in IN cord-252725-e3pazjdi 54 9 mice mouse NNS cord-252725-e3pazjdi 54 10 with with IN cord-252725-e3pazjdi 54 11 chronic chronic JJ cord-252725-e3pazjdi 54 12 obstructive obstructive JJ cord-252725-e3pazjdi 54 13 pulmonary pulmonary JJ cord-252725-e3pazjdi 54 14 disease disease NN cord-252725-e3pazjdi 54 15 ( ( -LRB- cord-252725-e3pazjdi 54 16 COPD COPD NNP cord-252725-e3pazjdi 54 17 ) ) -RRB- cord-252725-e3pazjdi 54 18 [ [ -LRB- cord-252725-e3pazjdi 54 19 38 38 CD cord-252725-e3pazjdi 54 20 ] ] -RRB- cord-252725-e3pazjdi 54 21 . . . cord-252725-e3pazjdi 55 1 Quercetin-3-β Quercetin-3-β NNP cord-252725-e3pazjdi 55 2 - - HYPH cord-252725-e3pazjdi 55 3 galactoside galactoside NNP cord-252725-e3pazjdi 55 4 , , , cord-252725-e3pazjdi 55 5 a a DT cord-252725-e3pazjdi 55 6 quercetin quercetin NN cord-252725-e3pazjdi 55 7 derivate derivate NN cord-252725-e3pazjdi 55 8 , , , cord-252725-e3pazjdi 55 9 was be VBD cord-252725-e3pazjdi 55 10 found find VBN cord-252725-e3pazjdi 55 11 to to TO cord-252725-e3pazjdi 55 12 inhibit inhibit VB cord-252725-e3pazjdi 55 13 in in IN cord-252725-e3pazjdi 55 14 vitro vitro FW cord-252725-e3pazjdi 55 15 a a DT cord-252725-e3pazjdi 55 16 protease protease NN cord-252725-e3pazjdi 55 17 essential essential JJ cord-252725-e3pazjdi 55 18 for for IN cord-252725-e3pazjdi 55 19 viral viral JJ cord-252725-e3pazjdi 55 20 replication replication NN cord-252725-e3pazjdi 55 21 of of IN cord-252725-e3pazjdi 55 22 SARS SARS NNP cord-252725-e3pazjdi 55 23 - - HYPH cord-252725-e3pazjdi 55 24 CoV CoV NNP cord-252725-e3pazjdi 55 25 [ [ -LRB- cord-252725-e3pazjdi 55 26 39 39 CD cord-252725-e3pazjdi 55 27 ] ] -RRB- cord-252725-e3pazjdi 55 28 and and CC cord-252725-e3pazjdi 55 29 to to TO cord-252725-e3pazjdi 55 30 block block VB cord-252725-e3pazjdi 55 31 the the DT cord-252725-e3pazjdi 55 32 enzymatic enzymatic JJ cord-252725-e3pazjdi 55 33 activity activity NN cord-252725-e3pazjdi 55 34 of of IN cord-252725-e3pazjdi 55 35 MERS MERS NNP cord-252725-e3pazjdi 55 36 - - HYPH cord-252725-e3pazjdi 55 37 CoV CoV NNP cord-252725-e3pazjdi 55 38 3CLpro 3clpro CD cord-252725-e3pazjdi 55 39 [ [ -LRB- cord-252725-e3pazjdi 55 40 40 40 CD cord-252725-e3pazjdi 55 41 ] ] -RRB- cord-252725-e3pazjdi 55 42 . . . cord-252725-e3pazjdi 56 1 Moreover moreover RB cord-252725-e3pazjdi 56 2 , , , cord-252725-e3pazjdi 56 3 quercetin quercetin NN cord-252725-e3pazjdi 56 4 has have VBZ cord-252725-e3pazjdi 56 5 been be VBN cord-252725-e3pazjdi 56 6 reported report VBN cord-252725-e3pazjdi 56 7 to to TO cord-252725-e3pazjdi 56 8 inhibit inhibit VB cord-252725-e3pazjdi 56 9 the the DT cord-252725-e3pazjdi 56 10 proteolytic proteolytic JJ cord-252725-e3pazjdi 56 11 activity activity NN cord-252725-e3pazjdi 56 12 of of IN cord-252725-e3pazjdi 56 13 SARS SARS NNP cord-252725-e3pazjdi 56 14 - - HYPH cord-252725-e3pazjdi 56 15 CoV CoV NNP cord-252725-e3pazjdi 56 16 3CLpro 3clpro CD cord-252725-e3pazjdi 57 1 [ [ -LRB- cord-252725-e3pazjdi 57 2 41 41 CD cord-252725-e3pazjdi 57 3 ] ] -RRB- cord-252725-e3pazjdi 57 4 from from IN cord-252725-e3pazjdi 57 5 the the DT cord-252725-e3pazjdi 57 6 same same JJ cord-252725-e3pazjdi 57 7 family family NN cord-252725-e3pazjdi 57 8 as as IN cord-252725-e3pazjdi 57 9 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 58 1 . . . cord-252725-e3pazjdi 59 1 Therefore therefore RB cord-252725-e3pazjdi 59 2 , , , cord-252725-e3pazjdi 59 3 these these DT cord-252725-e3pazjdi 59 4 properties property NNS cord-252725-e3pazjdi 59 5 of of IN cord-252725-e3pazjdi 59 6 quercetin quercetin NN cord-252725-e3pazjdi 59 7 could could MD cord-252725-e3pazjdi 59 8 render render VB cord-252725-e3pazjdi 59 9 it -PRON- PRP cord-252725-e3pazjdi 59 10 a a DT cord-252725-e3pazjdi 59 11 favorable favorable JJ cord-252725-e3pazjdi 59 12 natural natural JJ cord-252725-e3pazjdi 59 13 compound compound NN cord-252725-e3pazjdi 59 14 to to TO cord-252725-e3pazjdi 59 15 be be VB cord-252725-e3pazjdi 59 16 exploited exploit VBN cord-252725-e3pazjdi 59 17 in in IN cord-252725-e3pazjdi 59 18 the the DT cord-252725-e3pazjdi 59 19 medicinal medicinal JJ cord-252725-e3pazjdi 59 20 field field NN cord-252725-e3pazjdi 59 21 due due JJ cord-252725-e3pazjdi 59 22 chiefly chiefly RB cord-252725-e3pazjdi 59 23 to to IN cord-252725-e3pazjdi 59 24 its -PRON- PRP$ cord-252725-e3pazjdi 59 25 strong strong JJ cord-252725-e3pazjdi 59 26 antioxidant antioxidant JJ cord-252725-e3pazjdi 59 27 properties property NNS cord-252725-e3pazjdi 59 28 [ [ -LRB- cord-252725-e3pazjdi 59 29 42 42 CD cord-252725-e3pazjdi 59 30 ] ] -RRB- cord-252725-e3pazjdi 59 31 . . . cord-252725-e3pazjdi 60 1 Catechins Catechins NNP cord-252725-e3pazjdi 60 2 ( ( -LRB- cord-252725-e3pazjdi 60 3 Fig Fig NNP cord-252725-e3pazjdi 60 4 . . NNP cord-252725-e3pazjdi 60 5 2 2 LS cord-252725-e3pazjdi 60 6 ) ) -RRB- cord-252725-e3pazjdi 60 7 [ [ -LRB- cord-252725-e3pazjdi 60 8 43 43 CD cord-252725-e3pazjdi 60 9 ] ] -RRB- cord-252725-e3pazjdi 60 10 . . . cord-252725-e3pazjdi 61 1 Catechins catechin NNS cord-252725-e3pazjdi 61 2 present present VBP cord-252725-e3pazjdi 61 3 in in IN cord-252725-e3pazjdi 61 4 many many JJ cord-252725-e3pazjdi 61 5 dietary dietary JJ cord-252725-e3pazjdi 61 6 products product NNS cord-252725-e3pazjdi 61 7 , , , cord-252725-e3pazjdi 61 8 medicinal medicinal JJ cord-252725-e3pazjdi 61 9 plants plant NNS cord-252725-e3pazjdi 61 10 , , , cord-252725-e3pazjdi 61 11 and and CC cord-252725-e3pazjdi 61 12 fruits fruit NNS cord-252725-e3pazjdi 61 13 including include VBG cord-252725-e3pazjdi 61 14 apples apple NNS cord-252725-e3pazjdi 61 15 , , , cord-252725-e3pazjdi 61 16 blueberries blueberry NNS cord-252725-e3pazjdi 61 17 , , , cord-252725-e3pazjdi 61 18 gooseberries gooseberry NNS cord-252725-e3pazjdi 61 19 , , , cord-252725-e3pazjdi 61 20 grape grape NN cord-252725-e3pazjdi 61 21 seeds seed NNS cord-252725-e3pazjdi 61 22 , , , cord-252725-e3pazjdi 61 23 kiwi kiwi NN cord-252725-e3pazjdi 61 24 , , , cord-252725-e3pazjdi 61 25 strawberries strawberry NNS cord-252725-e3pazjdi 61 26 , , , cord-252725-e3pazjdi 61 27 green green JJ cord-252725-e3pazjdi 61 28 tea tea NN cord-252725-e3pazjdi 61 29 , , , cord-252725-e3pazjdi 61 30 red red JJ cord-252725-e3pazjdi 61 31 wine wine NN cord-252725-e3pazjdi 61 32 , , , cord-252725-e3pazjdi 61 33 beer beer NN cord-252725-e3pazjdi 61 34 , , , cord-252725-e3pazjdi 61 35 cacao cacao NN cord-252725-e3pazjdi 61 36 liquor liquor NN cord-252725-e3pazjdi 61 37 , , , cord-252725-e3pazjdi 61 38 chocolate chocolate NN cord-252725-e3pazjdi 61 39 , , , cord-252725-e3pazjdi 61 40 cocoa cocoa NN cord-252725-e3pazjdi 61 41 . . . cord-252725-e3pazjdi 62 1 Catechins Catechins NNP cord-252725-e3pazjdi 62 2 particularly particularly RB cord-252725-e3pazjdi 62 3 , , , cord-252725-e3pazjdi 62 4 those those DT cord-252725-e3pazjdi 62 5 found find VBN cord-252725-e3pazjdi 62 6 in in IN cord-252725-e3pazjdi 62 7 green green JJ cord-252725-e3pazjdi 62 8 tea tea NN cord-252725-e3pazjdi 62 9 ( ( -LRB- cord-252725-e3pazjdi 62 10 mainly mainly RB cord-252725-e3pazjdi 62 11 EGCG EGCG NNP cord-252725-e3pazjdi 62 12 and and CC cord-252725-e3pazjdi 62 13 EGC EGC NNP cord-252725-e3pazjdi 62 14 ) ) -RRB- cord-252725-e3pazjdi 62 15 have have VBP cord-252725-e3pazjdi 62 16 many many JJ cord-252725-e3pazjdi 62 17 favorable favorable JJ cord-252725-e3pazjdi 62 18 properties property NNS cord-252725-e3pazjdi 62 19 for for IN cord-252725-e3pazjdi 62 20 human human JJ cord-252725-e3pazjdi 62 21 health health NN cord-252725-e3pazjdi 62 22 and and CC cord-252725-e3pazjdi 62 23 were be VBD cord-252725-e3pazjdi 62 24 confirmed confirm VBN cord-252725-e3pazjdi 62 25 in in IN cord-252725-e3pazjdi 62 26 vivo vivo NN cord-252725-e3pazjdi 62 27 and and CC cord-252725-e3pazjdi 62 28 in in IN cord-252725-e3pazjdi 62 29 vitro vitro FW cord-252725-e3pazjdi 62 30 as as IN cord-252725-e3pazjdi 62 31 an an DT cord-252725-e3pazjdi 62 32 anticancer anticancer JJ cord-252725-e3pazjdi 62 33 , , , cord-252725-e3pazjdi 62 34 anti anti JJ cord-252725-e3pazjdi 62 35 - - JJ cord-252725-e3pazjdi 62 36 obesity obesity JJ cord-252725-e3pazjdi 62 37 , , , cord-252725-e3pazjdi 62 38 antidiabetic antidiabetic NNP cord-252725-e3pazjdi 62 39 , , , cord-252725-e3pazjdi 62 40 anti anti JJ cord-252725-e3pazjdi 62 41 - - JJ cord-252725-e3pazjdi 62 42 inflammatory inflammatory JJ cord-252725-e3pazjdi 62 43 , , , cord-252725-e3pazjdi 62 44 anti anti JJ cord-252725-e3pazjdi 62 45 - - JJ cord-252725-e3pazjdi 62 46 cardiovascular cardiovascular JJ cord-252725-e3pazjdi 62 47 , , , cord-252725-e3pazjdi 62 48 anti anti JJ cord-252725-e3pazjdi 62 49 - - JJ cord-252725-e3pazjdi 62 50 infectious infectious JJ cord-252725-e3pazjdi 62 51 , , , cord-252725-e3pazjdi 62 52 hepatoprotective hepatoprotective JJ cord-252725-e3pazjdi 62 53 , , , cord-252725-e3pazjdi 62 54 and and CC cord-252725-e3pazjdi 62 55 neuroprotective neuroprotective JJ cord-252725-e3pazjdi 62 56 [ [ -LRB- cord-252725-e3pazjdi 62 57 44 44 CD cord-252725-e3pazjdi 62 58 ] ] -RRB- cord-252725-e3pazjdi 62 59 . . . cord-252725-e3pazjdi 63 1 Catchins Catchins NNP cord-252725-e3pazjdi 63 2 of of IN cord-252725-e3pazjdi 63 3 green green JJ cord-252725-e3pazjdi 63 4 tea tea NN cord-252725-e3pazjdi 63 5 have have VBP cord-252725-e3pazjdi 63 6 been be VBN cord-252725-e3pazjdi 63 7 shown show VBN cord-252725-e3pazjdi 63 8 to to TO cord-252725-e3pazjdi 63 9 decrease decrease VB cord-252725-e3pazjdi 63 10 denaturation denaturation NN cord-252725-e3pazjdi 63 11 of of IN cord-252725-e3pazjdi 63 12 tissue tissue NN cord-252725-e3pazjdi 63 13 proteins protein NNS cord-252725-e3pazjdi 63 14 , , , cord-252725-e3pazjdi 63 15 ROS ROS NNP cord-252725-e3pazjdi 63 16 , , , cord-252725-e3pazjdi 63 17 free free JJ cord-252725-e3pazjdi 63 18 radical radical JJ cord-252725-e3pazjdi 63 19 and and CC cord-252725-e3pazjdi 63 20 NO no DT cord-252725-e3pazjdi 63 21 productions production NNS cord-252725-e3pazjdi 63 22 . . . cord-252725-e3pazjdi 64 1 On on IN cord-252725-e3pazjdi 64 2 the the DT cord-252725-e3pazjdi 64 3 contradictory contradictory JJ cord-252725-e3pazjdi 64 4 , , , cord-252725-e3pazjdi 64 5 they -PRON- PRP cord-252725-e3pazjdi 64 6 were be VBD cord-252725-e3pazjdi 64 7 found find VBN cord-252725-e3pazjdi 64 8 to to TO cord-252725-e3pazjdi 64 9 increase increase VB cord-252725-e3pazjdi 64 10 the the DT cord-252725-e3pazjdi 64 11 production production NN cord-252725-e3pazjdi 64 12 of of IN cord-252725-e3pazjdi 64 13 anti anti JJ cord-252725-e3pazjdi 64 14 - - JJ cord-252725-e3pazjdi 64 15 inflammatory inflammatory JJ cord-252725-e3pazjdi 64 16 cytokines cytokine NNS cord-252725-e3pazjdi 64 17 and and CC cord-252725-e3pazjdi 64 18 antioxidant antioxidant JJ cord-252725-e3pazjdi 64 19 enzymes enzyme NNS cord-252725-e3pazjdi 64 20 [ [ -LRB- cord-252725-e3pazjdi 64 21 45 45 CD cord-252725-e3pazjdi 64 22 , , , cord-252725-e3pazjdi 64 23 46 46 CD cord-252725-e3pazjdi 64 24 ] ] -RRB- cord-252725-e3pazjdi 64 25 . . . cord-252725-e3pazjdi 65 1 In in IN cord-252725-e3pazjdi 65 2 fact fact NN cord-252725-e3pazjdi 65 3 , , , cord-252725-e3pazjdi 65 4 catchins catchin NNS cord-252725-e3pazjdi 65 5 exert exert VBP cord-252725-e3pazjdi 65 6 a a DT cord-252725-e3pazjdi 65 7 strong strong JJ cord-252725-e3pazjdi 65 8 antiinflammatory antiinflammatory JJ cord-252725-e3pazjdi 65 9 property property NN cord-252725-e3pazjdi 65 10 due due IN cord-252725-e3pazjdi 65 11 to to IN cord-252725-e3pazjdi 65 12 their -PRON- PRP$ cord-252725-e3pazjdi 65 13 ability ability NN cord-252725-e3pazjdi 65 14 to to TO cord-252725-e3pazjdi 65 15 activate activate VB cord-252725-e3pazjdi 65 16 / / SYM cord-252725-e3pazjdi 65 17 deactivate deactivate VB cord-252725-e3pazjdi 65 18 inflammation inflammation NN cord-252725-e3pazjdi 65 19 - - HYPH cord-252725-e3pazjdi 65 20 related relate VBN cord-252725-e3pazjdi 65 21 oxidative oxidative JJ cord-252725-e3pazjdi 65 22 stress stress NN cord-252725-e3pazjdi 65 23 - - HYPH cord-252725-e3pazjdi 65 24 related relate VBN cord-252725-e3pazjdi 65 25 cell cell NN cord-252725-e3pazjdi 65 26 signaling signal VBG cord-252725-e3pazjdi 65 27 pathways pathway NNS cord-252725-e3pazjdi 65 28 , , , cord-252725-e3pazjdi 65 29 such such JJ cord-252725-e3pazjdi 65 30 as as IN cord-252725-e3pazjdi 65 31 NF NF NNP cord-252725-e3pazjdi 65 32 - - HYPH cord-252725-e3pazjdi 65 33 κB κB NNP cord-252725-e3pazjdi 65 34 , , , cord-252725-e3pazjdi 65 35 MAPKs MAPKs NNP cord-252725-e3pazjdi 65 36 , , , cord-252725-e3pazjdi 65 37 transcription transcription NN cord-252725-e3pazjdi 65 38 factor factor NN cord-252725-e3pazjdi 65 39 nuclear nuclear JJ cord-252725-e3pazjdi 65 40 factor factor NN cord-252725-e3pazjdi 65 41 ( ( -LRB- cord-252725-e3pazjdi 65 42 erythroid erythroid NN cord-252725-e3pazjdi 65 43 - - HYPH cord-252725-e3pazjdi 65 44 derived derive VBN cord-252725-e3pazjdi 65 45 2)-like 2)-like CD cord-252725-e3pazjdi 65 46 2 2 CD cord-252725-e3pazjdi 65 47 ( ( -LRB- cord-252725-e3pazjdi 65 48 Nrf2 Nrf2 NNP cord-252725-e3pazjdi 65 49 ) ) -RRB- cord-252725-e3pazjdi 65 50 , , , cord-252725-e3pazjdi 65 51 signal signal NN cord-252725-e3pazjdi 65 52 transducer transducer NN cord-252725-e3pazjdi 65 53 and and CC cord-252725-e3pazjdi 65 54 the the DT cord-252725-e3pazjdi 65 55 activator activator NN cord-252725-e3pazjdi 65 56 of of IN cord-252725-e3pazjdi 65 57 transcription transcription NN cord-252725-e3pazjdi 65 58 1/3 1/3 CD cord-252725-e3pazjdi 66 1 ( ( -LRB- cord-252725-e3pazjdi 66 2 STAT1/3 STAT1/3 NNP cord-252725-e3pazjdi 66 3 ) ) -RRB- cord-252725-e3pazjdi 66 4 . . . cord-252725-e3pazjdi 67 1 This this DT cord-252725-e3pazjdi 67 2 ability ability NN cord-252725-e3pazjdi 67 3 of of IN cord-252725-e3pazjdi 67 4 catchins catchin NNS cord-252725-e3pazjdi 67 5 to to TO cord-252725-e3pazjdi 67 6 interact interact VB cord-252725-e3pazjdi 67 7 with with IN cord-252725-e3pazjdi 67 8 those those DT cord-252725-e3pazjdi 67 9 pathways pathway NNS cord-252725-e3pazjdi 67 10 might may MD cord-252725-e3pazjdi 67 11 contribute contribute VB cord-252725-e3pazjdi 67 12 to to IN cord-252725-e3pazjdi 67 13 their -PRON- PRP$ cord-252725-e3pazjdi 67 14 role role NN cord-252725-e3pazjdi 67 15 in in IN cord-252725-e3pazjdi 67 16 inhibiting inhibit VBG cord-252725-e3pazjdi 67 17 the the DT cord-252725-e3pazjdi 67 18 infiltration infiltration NN cord-252725-e3pazjdi 67 19 and and CC cord-252725-e3pazjdi 67 20 proliferation proliferation NN cord-252725-e3pazjdi 67 21 of of IN cord-252725-e3pazjdi 67 22 immune immune NN cord-252725-e3pazjdi 67 23 - - HYPH cord-252725-e3pazjdi 67 24 related relate VBN cord-252725-e3pazjdi 67 25 cells cell NNS cord-252725-e3pazjdi 67 26 and and CC cord-252725-e3pazjdi 67 27 regulate regulate VB cord-252725-e3pazjdi 67 28 inflammation inflammation NN cord-252725-e3pazjdi 67 29 and and CC cord-252725-e3pazjdi 67 30 oxidative oxidative JJ cord-252725-e3pazjdi 67 31 reactions reaction NNS cord-252725-e3pazjdi 67 32 by by IN cord-252725-e3pazjdi 67 33 lowering lower VBG cord-252725-e3pazjdi 67 34 of of IN cord-252725-e3pazjdi 67 35 the the DT cord-252725-e3pazjdi 67 36 production production NN cord-252725-e3pazjdi 67 37 of of IN cord-252725-e3pazjdi 67 38 pro pro JJ cord-252725-e3pazjdi 67 39 - - JJ cord-252725-e3pazjdi 67 40 inflammatory inflammatory JJ cord-252725-e3pazjdi 67 41 cytokines cytokine NNS cord-252725-e3pazjdi 67 42 such such JJ cord-252725-e3pazjdi 67 43 as as IN cord-252725-e3pazjdi 67 44 IL-17 IL-17 NNP cord-252725-e3pazjdi 67 45 , , , cord-252725-e3pazjdi 67 46 chemokines chemokine NNS cord-252725-e3pazjdi 67 47 , , , cord-252725-e3pazjdi 67 48 adhesion adhesion NN cord-252725-e3pazjdi 67 49 molecules molecule NNS cord-252725-e3pazjdi 67 50 , , , cord-252725-e3pazjdi 67 51 and and CC cord-252725-e3pazjdi 67 52 inflammatory inflammatory JJ cord-252725-e3pazjdi 67 53 - - HYPH cord-252725-e3pazjdi 67 54 related relate VBN cord-252725-e3pazjdi 67 55 enzymes enzyme NNS cord-252725-e3pazjdi 67 56 , , , cord-252725-e3pazjdi 67 57 like like IN cord-252725-e3pazjdi 67 58 iNOS inos CD cord-252725-e3pazjdi 67 59 and and CC cord-252725-e3pazjdi 67 60 COX-2 COX-2 NNP cord-252725-e3pazjdi 67 61 , , , cord-252725-e3pazjdi 67 62 augmenting augment VBG cord-252725-e3pazjdi 67 63 the the DT cord-252725-e3pazjdi 67 64 production production NN cord-252725-e3pazjdi 67 65 of of IN cord-252725-e3pazjdi 67 66 the the DT cord-252725-e3pazjdi 67 67 anti anti JJ cord-252725-e3pazjdi 67 68 - - JJ cord-252725-e3pazjdi 67 69 inflammatory inflammatory JJ cord-252725-e3pazjdi 67 70 cytokines cytokine NNS cord-252725-e3pazjdi 67 71 such such JJ cord-252725-e3pazjdi 67 72 as as IN cord-252725-e3pazjdi 67 73 IL-10 IL-10 NNP cord-252725-e3pazjdi 67 74 , , , cord-252725-e3pazjdi 67 75 and and CC cord-252725-e3pazjdi 67 76 suppress suppress VB cord-252725-e3pazjdi 67 77 many many JJ cord-252725-e3pazjdi 67 78 oxidative oxidative JJ cord-252725-e3pazjdi 67 79 stress stress NN cord-252725-e3pazjdi 67 80 - - HYPH cord-252725-e3pazjdi 67 81 related relate VBN cord-252725-e3pazjdi 67 82 pathways pathway NNS cord-252725-e3pazjdi 67 83 responsible responsible JJ cord-252725-e3pazjdi 67 84 for for IN cord-252725-e3pazjdi 67 85 the the DT cord-252725-e3pazjdi 67 86 inflammation inflammation NN cord-252725-e3pazjdi 67 87 processes process NNS cord-252725-e3pazjdi 67 88 [ [ -LRB- cord-252725-e3pazjdi 67 89 43 43 CD cord-252725-e3pazjdi 67 90 , , , cord-252725-e3pazjdi 67 91 47 47 CD cord-252725-e3pazjdi 67 92 ] ] -RRB- cord-252725-e3pazjdi 67 93 . . . cord-252725-e3pazjdi 68 1 Several several JJ cord-252725-e3pazjdi 68 2 studies study NNS cord-252725-e3pazjdi 68 3 have have VBP cord-252725-e3pazjdi 68 4 indicated indicate VBN cord-252725-e3pazjdi 68 5 the the DT cord-252725-e3pazjdi 68 6 role role NN cord-252725-e3pazjdi 68 7 of of IN cord-252725-e3pazjdi 68 8 catchins catchin NNS cord-252725-e3pazjdi 68 9 in in IN cord-252725-e3pazjdi 68 10 preventing prevent VBG cord-252725-e3pazjdi 68 11 infectious infectious JJ cord-252725-e3pazjdi 68 12 diseases disease NNS cord-252725-e3pazjdi 68 13 [ [ -LRB- cord-252725-e3pazjdi 68 14 48 48 CD cord-252725-e3pazjdi 68 15 ] ] -RRB- cord-252725-e3pazjdi 68 16 . . . cord-252725-e3pazjdi 69 1 Regular regular JJ cord-252725-e3pazjdi 69 2 consumption consumption NN cord-252725-e3pazjdi 69 3 of of IN cord-252725-e3pazjdi 69 4 green green JJ cord-252725-e3pazjdi 69 5 tea tea NN cord-252725-e3pazjdi 69 6 has have VBZ cord-252725-e3pazjdi 69 7 been be VBN cord-252725-e3pazjdi 69 8 shown show VBN cord-252725-e3pazjdi 69 9 to to TO cord-252725-e3pazjdi 69 10 decrease decrease VB cord-252725-e3pazjdi 69 11 influenza influenza NN cord-252725-e3pazjdi 69 12 infection infection NN cord-252725-e3pazjdi 69 13 and and CC cord-252725-e3pazjdi 69 14 some some DT cord-252725-e3pazjdi 69 15 cold cold JJ cord-252725-e3pazjdi 69 16 symptom symptom NN cord-252725-e3pazjdi 69 17 rates rate NNS cord-252725-e3pazjdi 69 18 . . . cord-252725-e3pazjdi 70 1 In in IN cord-252725-e3pazjdi 70 2 addition addition NN cord-252725-e3pazjdi 70 3 , , , cord-252725-e3pazjdi 70 4 gargling gargle VBG cord-252725-e3pazjdi 70 5 with with IN cord-252725-e3pazjdi 70 6 tea tea NN cord-252725-e3pazjdi 70 7 catechins catechin NNS cord-252725-e3pazjdi 70 8 protects protect VBZ cord-252725-e3pazjdi 70 9 against against IN cord-252725-e3pazjdi 70 10 influenza influenza NN cord-252725-e3pazjdi 70 11 infection infection NN cord-252725-e3pazjdi 70 12 and and CC cord-252725-e3pazjdi 70 13 common common JJ cord-252725-e3pazjdi 70 14 cold cold JJ cord-252725-e3pazjdi 70 15 [ [ -LRB- cord-252725-e3pazjdi 70 16 49 49 CD cord-252725-e3pazjdi 70 17 ] ] -RRB- cord-252725-e3pazjdi 70 18 . . . cord-252725-e3pazjdi 71 1 A a DT cord-252725-e3pazjdi 71 2 study study NN cord-252725-e3pazjdi 71 3 has have VBZ cord-252725-e3pazjdi 71 4 also also RB cord-252725-e3pazjdi 71 5 shown show VBN cord-252725-e3pazjdi 71 6 that that IN cord-252725-e3pazjdi 71 7 consuming consume VBG cord-252725-e3pazjdi 71 8 green green JJ cord-252725-e3pazjdi 71 9 tea tea NN cord-252725-e3pazjdi 71 10 supplements supplement NNS cord-252725-e3pazjdi 71 11 twice twice RB cord-252725-e3pazjdi 71 12 daily daily RB cord-252725-e3pazjdi 71 13 for for IN cord-252725-e3pazjdi 71 14 3 3 CD cord-252725-e3pazjdi 71 15 months month NNS cord-252725-e3pazjdi 71 16 resulted result VBN cord-252725-e3pazjdi 71 17 in in IN cord-252725-e3pazjdi 71 18 a a DT cord-252725-e3pazjdi 71 19 significant significant JJ cord-252725-e3pazjdi 71 20 decrease decrease NN cord-252725-e3pazjdi 71 21 in in IN cord-252725-e3pazjdi 71 22 cold cold NN cord-252725-e3pazjdi 71 23 or or CC cord-252725-e3pazjdi 71 24 influenza influenza NN cord-252725-e3pazjdi 71 25 symptoms symptom NNS cord-252725-e3pazjdi 71 26 by by IN cord-252725-e3pazjdi 71 27 approximately approximately RB cord-252725-e3pazjdi 71 28 23 23 CD cord-252725-e3pazjdi 71 29 % % NN cord-252725-e3pazjdi 71 30 . . . cord-252725-e3pazjdi 72 1 Moreover moreover RB cord-252725-e3pazjdi 72 2 , , , cord-252725-e3pazjdi 72 3 green green JJ cord-252725-e3pazjdi 72 4 tea tea NN cord-252725-e3pazjdi 72 5 consumption consumption NN cord-252725-e3pazjdi 72 6 per per IN cord-252725-e3pazjdi 72 7 day day NN cord-252725-e3pazjdi 72 8 or or CC cord-252725-e3pazjdi 72 9 per per IN cord-252725-e3pazjdi 72 10 week week NN cord-252725-e3pazjdi 72 11 was be VBD cord-252725-e3pazjdi 72 12 in in IN cord-252725-e3pazjdi 72 13 reverse reverse NN cord-252725-e3pazjdi 72 14 to to IN cord-252725-e3pazjdi 72 15 the the DT cord-252725-e3pazjdi 72 16 instance instance NN cord-252725-e3pazjdi 72 17 numbers number NNS cord-252725-e3pazjdi 72 18 of of IN cord-252725-e3pazjdi 72 19 influenza influenza NN cord-252725-e3pazjdi 72 20 A a NN cord-252725-e3pazjdi 72 21 or or CC cord-252725-e3pazjdi 72 22 B b NN cord-252725-e3pazjdi 72 23 among among IN cord-252725-e3pazjdi 72 24 school school NN cord-252725-e3pazjdi 72 25 children child NNS cord-252725-e3pazjdi 72 26 in in IN cord-252725-e3pazjdi 72 27 Japan Japan NNP cord-252725-e3pazjdi 72 28 [ [ -LRB- cord-252725-e3pazjdi 72 29 50 50 CD cord-252725-e3pazjdi 72 30 ] ] -RRB- cord-252725-e3pazjdi 72 31 . . . cord-252725-e3pazjdi 73 1 Catechin Catechin NNP cord-252725-e3pazjdi 73 2 compounds compound NNS cord-252725-e3pazjdi 73 3 were be VBD cord-252725-e3pazjdi 73 4 also also RB cord-252725-e3pazjdi 73 5 shown show VBN cord-252725-e3pazjdi 73 6 to to TO cord-252725-e3pazjdi 73 7 exhibit exhibit VB cord-252725-e3pazjdi 73 8 high high JJ cord-252725-e3pazjdi 73 9 binding bind VBG cord-252725-e3pazjdi 73 10 affinity affinity NN cord-252725-e3pazjdi 73 11 to to IN cord-252725-e3pazjdi 73 12 Papain Papain NNP cord-252725-e3pazjdi 73 13 - - HYPH cord-252725-e3pazjdi 73 14 like like JJ cord-252725-e3pazjdi 73 15 proteinase proteinase NN cord-252725-e3pazjdi 73 16 ( ( -LRB- cord-252725-e3pazjdi 73 17 PLpro PLpro NNP cord-252725-e3pazjdi 73 18 ) ) -RRB- cord-252725-e3pazjdi 73 19 which which WDT cord-252725-e3pazjdi 73 20 is be VBZ cord-252725-e3pazjdi 73 21 involved involve VBN cord-252725-e3pazjdi 73 22 in in IN cord-252725-e3pazjdi 73 23 RNA RNA NNP cord-252725-e3pazjdi 73 24 SARS SARS NNP cord-252725-e3pazjdi 73 25 - - HYPH cord-252725-e3pazjdi 73 26 CoV-2 CoV-2 NNP cord-252725-e3pazjdi 73 27 replication replication NN cord-252725-e3pazjdi 73 28 , , , cord-252725-e3pazjdi 73 29 suggesting suggest VBG cord-252725-e3pazjdi 73 30 the the DT cord-252725-e3pazjdi 73 31 potential potential JJ cord-252725-e3pazjdi 73 32 effectiveness effectiveness NN cord-252725-e3pazjdi 73 33 of of IN cord-252725-e3pazjdi 73 34 these these DT cord-252725-e3pazjdi 73 35 compounds compound NNS cord-252725-e3pazjdi 73 36 in in IN cord-252725-e3pazjdi 73 37 the the DT cord-252725-e3pazjdi 73 38 treatment treatment NN cord-252725-e3pazjdi 73 39 of of IN cord-252725-e3pazjdi 73 40 SARS SARS NNP cord-252725-e3pazjdi 73 41 - - HYPH cord-252725-e3pazjdi 73 42 CoV-2 CoV-2 NNP cord-252725-e3pazjdi 73 43 [ [ -LRB- cord-252725-e3pazjdi 73 44 51 51 CD cord-252725-e3pazjdi 73 45 , , , cord-252725-e3pazjdi 73 46 52 52 CD cord-252725-e3pazjdi 73 47 ] ] -RRB- cord-252725-e3pazjdi 73 48 . . . cord-252725-e3pazjdi 74 1 EGCG EGCG NNP cord-252725-e3pazjdi 74 2 derivatives derivative NNS cord-252725-e3pazjdi 74 3 such such JJ cord-252725-e3pazjdi 74 4 as as IN cord-252725-e3pazjdi 74 5 EGCG EGCG NNP cord-252725-e3pazjdi 74 6 - - HYPH cord-252725-e3pazjdi 74 7 fatty fatty JJ cord-252725-e3pazjdi 74 8 acid acid NN cord-252725-e3pazjdi 74 9 monoesters monoester NNS cord-252725-e3pazjdi 74 10 were be VBD cord-252725-e3pazjdi 74 11 found find VBN cord-252725-e3pazjdi 74 12 to to TO cord-252725-e3pazjdi 74 13 be be VB cord-252725-e3pazjdi 74 14 as as IN cord-252725-e3pazjdi 74 15 an an DT cord-252725-e3pazjdi 74 16 innovative innovative JJ cord-252725-e3pazjdi 74 17 approach approach NN cord-252725-e3pazjdi 74 18 to to IN cord-252725-e3pazjdi 74 19 the the DT cord-252725-e3pazjdi 74 20 prevention prevention NN cord-252725-e3pazjdi 74 21 of of IN cord-252725-e3pazjdi 74 22 viral viral JJ cord-252725-e3pazjdi 74 23 infections infection NNS cord-252725-e3pazjdi 74 24 including include VBG cord-252725-e3pazjdi 74 25 emerging emerge VBG cord-252725-e3pazjdi 74 26 fatal fatal JJ cord-252725-e3pazjdi 74 27 viruses virus NNS cord-252725-e3pazjdi 74 28 , , , cord-252725-e3pazjdi 74 29 such such JJ cord-252725-e3pazjdi 74 30 as as IN cord-252725-e3pazjdi 74 31 Ebola Ebola NNP cord-252725-e3pazjdi 74 32 virus virus NN cord-252725-e3pazjdi 74 33 , , , cord-252725-e3pazjdi 74 34 SARS SARS NNP cord-252725-e3pazjdi 74 35 virus virus NN cord-252725-e3pazjdi 74 36 and and CC cord-252725-e3pazjdi 74 37 MERS MERS NNP cord-252725-e3pazjdi 74 38 virus virus NN cord-252725-e3pazjdi 74 39 [ [ -LRB- cord-252725-e3pazjdi 74 40 53 53 CD cord-252725-e3pazjdi 74 41 ] ] -RRB- cord-252725-e3pazjdi 74 42 . . . cord-252725-e3pazjdi 75 1 In in IN cord-252725-e3pazjdi 75 2 fact fact NN cord-252725-e3pazjdi 75 3 , , , cord-252725-e3pazjdi 75 4 this this DT cord-252725-e3pazjdi 75 5 action action NN cord-252725-e3pazjdi 75 6 is be VBZ cord-252725-e3pazjdi 75 7 probably probably RB cord-252725-e3pazjdi 75 8 due due JJ cord-252725-e3pazjdi 75 9 to to IN cord-252725-e3pazjdi 75 10 their -PRON- PRP$ cord-252725-e3pazjdi 75 11 increased increase VBN cord-252725-e3pazjdi 75 12 affinity affinity NN cord-252725-e3pazjdi 75 13 for for IN cord-252725-e3pazjdi 75 14 viruses virus NNS cord-252725-e3pazjdi 75 15 and and CC cord-252725-e3pazjdi 75 16 cellular cellular JJ cord-252725-e3pazjdi 75 17 membranes membrane NNS cord-252725-e3pazjdi 75 18 [ [ -LRB- cord-252725-e3pazjdi 75 19 54 54 CD cord-252725-e3pazjdi 75 20 ] ] -RRB- cord-252725-e3pazjdi 75 21 . . . cord-252725-e3pazjdi 76 1 Catechins catechin NNS cord-252725-e3pazjdi 76 2 as as IN cord-252725-e3pazjdi 76 3 the the DT cord-252725-e3pazjdi 76 4 major major JJ cord-252725-e3pazjdi 76 5 content content NN cord-252725-e3pazjdi 76 6 of of IN cord-252725-e3pazjdi 76 7 green green JJ cord-252725-e3pazjdi 76 8 tea tea NN cord-252725-e3pazjdi 76 9 may may MD cord-252725-e3pazjdi 76 10 be be VB cord-252725-e3pazjdi 76 11 a a DT cord-252725-e3pazjdi 76 12 potential potential JJ cord-252725-e3pazjdi 76 13 treatment treatment NN cord-252725-e3pazjdi 76 14 of of IN cord-252725-e3pazjdi 76 15 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 76 16 , , , cord-252725-e3pazjdi 76 17 caused cause VBN cord-252725-e3pazjdi 76 18 by by IN cord-252725-e3pazjdi 76 19 the the DT cord-252725-e3pazjdi 76 20 new new JJ cord-252725-e3pazjdi 76 21 coronavirus coronavirus NN cord-252725-e3pazjdi 76 22 that that WDT cord-252725-e3pazjdi 76 23 is be VBZ cord-252725-e3pazjdi 76 24 nominated nominate VBN cord-252725-e3pazjdi 76 25 as as IN cord-252725-e3pazjdi 76 26 severe severe JJ cord-252725-e3pazjdi 76 27 acute acute JJ cord-252725-e3pazjdi 76 28 respiratory respiratory JJ cord-252725-e3pazjdi 76 29 syndrome syndrome NN cord-252725-e3pazjdi 76 30 - - HYPH cord-252725-e3pazjdi 76 31 related relate VBN cord-252725-e3pazjdi 76 32 coronavirus coronavirus NN cord-252725-e3pazjdi 76 33 SARS SARS NNP cord-252725-e3pazjdi 76 34 - - : cord-252725-e3pazjdi 76 35 CoV-2 CoV-2 NNP cord-252725-e3pazjdi 76 36 especially especially RB cord-252725-e3pazjdi 76 37 , , , cord-252725-e3pazjdi 76 38 the the DT cord-252725-e3pazjdi 76 39 breath breath NN cord-252725-e3pazjdi 76 40 shortens shorten VBZ cord-252725-e3pazjdi 76 41 and and CC cord-252725-e3pazjdi 76 42 other other JJ cord-252725-e3pazjdi 76 43 symptoms symptom NNS cord-252725-e3pazjdi 76 44 related relate VBN cord-252725-e3pazjdi 76 45 to to IN cord-252725-e3pazjdi 76 46 this this DT cord-252725-e3pazjdi 76 47 emerging emerge VBG cord-252725-e3pazjdi 76 48 virus virus NN cord-252725-e3pazjdi 76 49 infection infection NN cord-252725-e3pazjdi 76 50 . . . cord-252725-e3pazjdi 77 1 Rutin Rutin NNP cord-252725-e3pazjdi 77 2 ( ( -LRB- cord-252725-e3pazjdi 77 3 3,3′,4′,5,7-pentahydroxyflavone-3-rhamnoglucoside 3,3′,4′,5,7-pentahydroxyflavone-3-rhamnoglucoside CD cord-252725-e3pazjdi 77 4 ) ) -RRB- cord-252725-e3pazjdi 77 5 ( ( -LRB- cord-252725-e3pazjdi 77 6 Fig Fig NNP cord-252725-e3pazjdi 77 7 . . . cord-252725-e3pazjdi 77 8 3 3 CD cord-252725-e3pazjdi 77 9 ) ) -RRB- cord-252725-e3pazjdi 77 10 , , , cord-252725-e3pazjdi 77 11 is be VBZ cord-252725-e3pazjdi 77 12 another another DT cord-252725-e3pazjdi 77 13 important important JJ cord-252725-e3pazjdi 77 14 naturally naturally RB cord-252725-e3pazjdi 77 15 occurring occur VBG cord-252725-e3pazjdi 77 16 flavonoids flavonoid NNS cord-252725-e3pazjdi 77 17 also also RB cord-252725-e3pazjdi 77 18 known know VBN cord-252725-e3pazjdi 77 19 as as IN cord-252725-e3pazjdi 77 20 rutoside rutoside NN cord-252725-e3pazjdi 77 21 , , , cord-252725-e3pazjdi 77 22 quercetin-3-O quercetin-3-o NN cord-252725-e3pazjdi 77 23 - - HYPH cord-252725-e3pazjdi 77 24 rutinoside rutinoside NN cord-252725-e3pazjdi 77 25 , , , cord-252725-e3pazjdi 77 26 sophorin sophorin NN cord-252725-e3pazjdi 77 27 and and CC cord-252725-e3pazjdi 77 28 vitamin vitamin NN cord-252725-e3pazjdi 77 29 P p NN cord-252725-e3pazjdi 77 30 [ [ -LRB- cord-252725-e3pazjdi 77 31 55 55 CD cord-252725-e3pazjdi 77 32 ] ] -RRB- cord-252725-e3pazjdi 77 33 . . . cord-252725-e3pazjdi 78 1 Rutin Rutin NNP cord-252725-e3pazjdi 78 2 , , , cord-252725-e3pazjdi 78 3 like like IN cord-252725-e3pazjdi 78 4 other other JJ cord-252725-e3pazjdi 78 5 polyphenolic polyphenolic JJ cord-252725-e3pazjdi 78 6 compounds compound NNS cord-252725-e3pazjdi 78 7 is be VBZ cord-252725-e3pazjdi 78 8 found find VBN cord-252725-e3pazjdi 78 9 in in IN cord-252725-e3pazjdi 78 10 several several JJ cord-252725-e3pazjdi 78 11 fruits fruit NNS cord-252725-e3pazjdi 78 12 and and CC cord-252725-e3pazjdi 78 13 vegetables vegetable NNS cord-252725-e3pazjdi 78 14 such such JJ cord-252725-e3pazjdi 78 15 as as IN cord-252725-e3pazjdi 78 16 apple apple NN cord-252725-e3pazjdi 78 17 peels peel NNS cord-252725-e3pazjdi 78 18 , , , cord-252725-e3pazjdi 78 19 black black JJ cord-252725-e3pazjdi 78 20 tea tea NN cord-252725-e3pazjdi 78 21 , , , cord-252725-e3pazjdi 78 22 asparagus asparagus NN cord-252725-e3pazjdi 78 23 , , , cord-252725-e3pazjdi 78 24 buckwheat buckwheat NN cord-252725-e3pazjdi 78 25 , , , cord-252725-e3pazjdi 78 26 onions onion NNS cord-252725-e3pazjdi 78 27 , , , cord-252725-e3pazjdi 78 28 green green JJ cord-252725-e3pazjdi 78 29 tea tea NN cord-252725-e3pazjdi 78 30 , , , cord-252725-e3pazjdi 78 31 figs fig NNS cord-252725-e3pazjdi 78 32 , , , cord-252725-e3pazjdi 78 33 and and CC cord-252725-e3pazjdi 78 34 most most JJS cord-252725-e3pazjdi 78 35 citrus citrus JJ cord-252725-e3pazjdi 78 36 fruit fruit NN cord-252725-e3pazjdi 78 37 like like IN cord-252725-e3pazjdi 78 38 grapefruit grapefruit NN cord-252725-e3pazjdi 78 39 , , , cord-252725-e3pazjdi 78 40 lemon lemon NN cord-252725-e3pazjdi 78 41 , , , cord-252725-e3pazjdi 78 42 lime lime NN cord-252725-e3pazjdi 78 43 , , , cord-252725-e3pazjdi 78 44 apple apple NN cord-252725-e3pazjdi 78 45 , , , cord-252725-e3pazjdi 78 46 berries berry NNS cord-252725-e3pazjdi 78 47 ( ( -LRB- cord-252725-e3pazjdi 78 48 mulberry mulberry NN cord-252725-e3pazjdi 78 49 ) ) -RRB- cord-252725-e3pazjdi 78 50 , , , cord-252725-e3pazjdi 78 51 ash ash NN cord-252725-e3pazjdi 78 52 tree tree NN cord-252725-e3pazjdi 78 53 fruits fruit NNS cord-252725-e3pazjdi 78 54 , , , cord-252725-e3pazjdi 78 55 and and CC cord-252725-e3pazjdi 78 56 cranberries cranberry NNS cord-252725-e3pazjdi 78 57 . . . cord-252725-e3pazjdi 79 1 Rutin Rutin NNP cord-252725-e3pazjdi 79 2 was be VBD cord-252725-e3pazjdi 79 3 also also RB cord-252725-e3pazjdi 79 4 found find VBN cord-252725-e3pazjdi 79 5 in in IN cord-252725-e3pazjdi 79 6 several several JJ cord-252725-e3pazjdi 79 7 African african JJ cord-252725-e3pazjdi 79 8 medical medical JJ cord-252725-e3pazjdi 79 9 plants plant NNS cord-252725-e3pazjdi 79 10 such such JJ cord-252725-e3pazjdi 79 11 as as IN cord-252725-e3pazjdi 79 12 Araliaceae Araliaceae NNP cord-252725-e3pazjdi 79 13 , , , cord-252725-e3pazjdi 79 14 Moringaceae Moringaceae NNP cord-252725-e3pazjdi 79 15 , , , cord-252725-e3pazjdi 79 16 Leguminosae Leguminosae NNP cord-252725-e3pazjdi 79 17 , , , cord-252725-e3pazjdi 79 18 Guttiferae Guttiferae NNP cord-252725-e3pazjdi 79 19 , , , cord-252725-e3pazjdi 79 20 Euphorbiaceae Euphorbiaceae NNP cord-252725-e3pazjdi 79 21 , , , cord-252725-e3pazjdi 79 22 and and CC cord-252725-e3pazjdi 79 23 Convolvulaceae Convolvulaceae NNP cord-252725-e3pazjdi 79 24 [ [ -LRB- cord-252725-e3pazjdi 79 25 56 56 CD cord-252725-e3pazjdi 79 26 ] ] -RRB- cord-252725-e3pazjdi 79 27 . . . cord-252725-e3pazjdi 80 1 Rutin Rutin NNP cord-252725-e3pazjdi 80 2 has have VBZ cord-252725-e3pazjdi 80 3 demonstrated demonstrate VBN cord-252725-e3pazjdi 80 4 a a DT cord-252725-e3pazjdi 80 5 number number NN cord-252725-e3pazjdi 80 6 of of IN cord-252725-e3pazjdi 80 7 beneficial beneficial JJ cord-252725-e3pazjdi 80 8 activities activity NNS cord-252725-e3pazjdi 80 9 , , , cord-252725-e3pazjdi 80 10 including include VBG cord-252725-e3pazjdi 80 11 antioxidant antioxidant JJ cord-252725-e3pazjdi 80 12 , , , cord-252725-e3pazjdi 80 13 anti anti JJ cord-252725-e3pazjdi 80 14 - - JJ cord-252725-e3pazjdi 80 15 inflammatory inflammatory JJ cord-252725-e3pazjdi 80 16 , , , cord-252725-e3pazjdi 80 17 cytoprotective cytoprotective NNP cord-252725-e3pazjdi 80 18 , , , cord-252725-e3pazjdi 80 19 vasoprotective vasoprotective NNP cord-252725-e3pazjdi 80 20 , , , cord-252725-e3pazjdi 80 21 anticarcinogenic anticarcinogenic NNP cord-252725-e3pazjdi 80 22 , , , cord-252725-e3pazjdi 80 23 neuroprotective neuroprotective JJ cord-252725-e3pazjdi 80 24 , , , cord-252725-e3pazjdi 80 25 cardioprotective cardioprotective JJ cord-252725-e3pazjdi 80 26 , , , cord-252725-e3pazjdi 80 27 antiasthmatic antiasthmatic NNP cord-252725-e3pazjdi 80 28 , , , cord-252725-e3pazjdi 80 29 antimycobacterial antimycobacterial JJ cord-252725-e3pazjdi 80 30 , , , cord-252725-e3pazjdi 80 31 antifungal antifungal JJ cord-252725-e3pazjdi 80 32 and and CC cord-252725-e3pazjdi 80 33 antiviral antiviral JJ cord-252725-e3pazjdi 80 34 activities activity NNS cord-252725-e3pazjdi 80 35 [ [ -LRB- cord-252725-e3pazjdi 80 36 57 57 CD cord-252725-e3pazjdi 80 37 ] ] -RRB- cord-252725-e3pazjdi 80 38 . . . cord-252725-e3pazjdi 81 1 In in IN cord-252725-e3pazjdi 81 2 fact fact NN cord-252725-e3pazjdi 81 3 , , , cord-252725-e3pazjdi 81 4 rutin rutin NN cord-252725-e3pazjdi 81 5 exerts exert VBZ cord-252725-e3pazjdi 81 6 its -PRON- PRP$ cord-252725-e3pazjdi 81 7 main main JJ cord-252725-e3pazjdi 81 8 activities activity NNS cord-252725-e3pazjdi 81 9 from from IN cord-252725-e3pazjdi 81 10 its -PRON- PRP$ cord-252725-e3pazjdi 81 11 ability ability NN cord-252725-e3pazjdi 81 12 to to TO cord-252725-e3pazjdi 81 13 inhibit inhibit VB cord-252725-e3pazjdi 81 14 the the DT cord-252725-e3pazjdi 81 15 nuclear nuclear JJ cord-252725-e3pazjdi 81 16 factor factor NN cord-252725-e3pazjdi 82 1 NFκB NFκB NNP cord-252725-e3pazjdi 82 2 , , , cord-252725-e3pazjdi 82 3 ERK1/2 ERK1/2 NNP cord-252725-e3pazjdi 82 4 up up IN cord-252725-e3pazjdi 82 5 - - HYPH cord-252725-e3pazjdi 82 6 regulation regulation NN cord-252725-e3pazjdi 82 7 of of IN cord-252725-e3pazjdi 82 8 Nrf Nrf NNP cord-252725-e3pazjdi 82 9 which which WDT cord-252725-e3pazjdi 82 10 leads lead VBZ cord-252725-e3pazjdi 82 11 to to IN cord-252725-e3pazjdi 82 12 reduced reduce VBN cord-252725-e3pazjdi 82 13 pro pro JJ cord-252725-e3pazjdi 82 14 - - JJ cord-252725-e3pazjdi 82 15 inflammatory inflammatory JJ cord-252725-e3pazjdi 82 16 agents agent NNS cord-252725-e3pazjdi 82 17 such such JJ cord-252725-e3pazjdi 82 18 as as IN cord-252725-e3pazjdi 82 19 IL-6 IL-6 NNP cord-252725-e3pazjdi 82 20 , , , cord-252725-e3pazjdi 82 21 TNF TNF NNP cord-252725-e3pazjdi 82 22 - - HYPH cord-252725-e3pazjdi 82 23 α α NNP cord-252725-e3pazjdi 82 24 , , , cord-252725-e3pazjdi 82 25 VCAM-1 VCAM-1 NNP cord-252725-e3pazjdi 82 26 , , , cord-252725-e3pazjdi 82 27 ICAM-1 ICAM-1 NNP cord-252725-e3pazjdi 82 28 , , , cord-252725-e3pazjdi 82 29 and and CC cord-252725-e3pazjdi 82 30 E e NN cord-252725-e3pazjdi 82 31 - - NN cord-252725-e3pazjdi 82 32 selectin selectin JJ cord-252725-e3pazjdi 82 33 [ [ -LRB- cord-252725-e3pazjdi 82 34 58 58 CD cord-252725-e3pazjdi 82 35 ] ] -RRB- cord-252725-e3pazjdi 82 36 . . . cord-252725-e3pazjdi 83 1 A a DT cord-252725-e3pazjdi 83 2 combination combination NN cord-252725-e3pazjdi 83 3 of of IN cord-252725-e3pazjdi 83 4 rutin rutin NN cord-252725-e3pazjdi 83 5 and and CC cord-252725-e3pazjdi 83 6 chloroquine chloroquine NN cord-252725-e3pazjdi 83 7 successfully successfully RB cord-252725-e3pazjdi 83 8 discloses disclose VBZ cord-252725-e3pazjdi 83 9 an an DT cord-252725-e3pazjdi 83 10 antimalarial antimalarial JJ cord-252725-e3pazjdi 83 11 activity activity NN cord-252725-e3pazjdi 83 12 in in IN cord-252725-e3pazjdi 83 13 white white JJ cord-252725-e3pazjdi 83 14 leghorn leghorn NNP cord-252725-e3pazjdi 83 15 chickens chicken NNS cord-252725-e3pazjdi 83 16 infected infect VBN cord-252725-e3pazjdi 83 17 with with IN cord-252725-e3pazjdi 83 18 Plasmodium Plasmodium NNP cord-252725-e3pazjdi 83 19 ( ( -LRB- cord-252725-e3pazjdi 83 20 Bennettinia Bennettinia NNP cord-252725-e3pazjdi 83 21 ) ) -RRB- cord-252725-e3pazjdi 83 22 juxtanucleare juxtanucleare NNP cord-252725-e3pazjdi 83 23 [ [ -LRB- cord-252725-e3pazjdi 83 24 59 59 CD cord-252725-e3pazjdi 83 25 ] ] -RRB- cord-252725-e3pazjdi 83 26 . . . cord-252725-e3pazjdi 84 1 Sodium sodium NN cord-252725-e3pazjdi 84 2 rutin rutin NN cord-252725-e3pazjdi 84 3 sulfate sulfate NN cord-252725-e3pazjdi 84 4 , , , cord-252725-e3pazjdi 84 5 a a DT cord-252725-e3pazjdi 84 6 sulfated sulfated JJ cord-252725-e3pazjdi 84 7 rutin rutin NN cord-252725-e3pazjdi 84 8 modified modify VBN cord-252725-e3pazjdi 84 9 from from IN cord-252725-e3pazjdi 84 10 the the DT cord-252725-e3pazjdi 84 11 natural natural JJ cord-252725-e3pazjdi 84 12 flavonol flavonol NNP cord-252725-e3pazjdi 84 13 glycoside glycoside NN cord-252725-e3pazjdi 84 14 rutin rutin NN cord-252725-e3pazjdi 84 15 was be VBD cord-252725-e3pazjdi 84 16 revealed reveal VBN cord-252725-e3pazjdi 84 17 in in IN cord-252725-e3pazjdi 84 18 vitro vitro FW cord-252725-e3pazjdi 84 19 to to TO cord-252725-e3pazjdi 84 20 possess possess VB cord-252725-e3pazjdi 84 21 an an DT cord-252725-e3pazjdi 84 22 antiretroviral antiretroviral JJ cord-252725-e3pazjdi 84 23 effect effect NN cord-252725-e3pazjdi 84 24 against against IN cord-252725-e3pazjdi 84 25 HIV-1 HIV-1 NNP cord-252725-e3pazjdi 84 26 X X NNP cord-252725-e3pazjdi 84 27 4 4 CD cord-252725-e3pazjdi 84 28 viruses virus NNS cord-252725-e3pazjdi 84 29 IIIB IIIB NNP cord-252725-e3pazjdi 84 30 , , , cord-252725-e3pazjdi 84 31 HIV-1 HIV-1 NNP cord-252725-e3pazjdi 84 32 R5 R5 NNP cord-252725-e3pazjdi 84 33 isolates isolate VBZ cord-252725-e3pazjdi 84 34 Ada Ada NNP cord-252725-e3pazjdi 84 35 - - HYPH cord-252725-e3pazjdi 84 36 M M NNP cord-252725-e3pazjdi 84 37 and and CC cord-252725-e3pazjdi 84 38 Ba Ba NNP cord-252725-e3pazjdi 84 39 - - HYPH cord-252725-e3pazjdi 84 40 L L NNP cord-252725-e3pazjdi 84 41 strains strain NNS cord-252725-e3pazjdi 84 42 by by IN cord-252725-e3pazjdi 84 43 blocking block VBG cord-252725-e3pazjdi 84 44 viral viral JJ cord-252725-e3pazjdi 84 45 entry entry NN cord-252725-e3pazjdi 84 46 and and CC cord-252725-e3pazjdi 84 47 virus virus NN cord-252725-e3pazjdi 84 48 - - HYPH cord-252725-e3pazjdi 84 49 cell cell NN cord-252725-e3pazjdi 84 50 fusion fusion NN cord-252725-e3pazjdi 84 51 through through IN cord-252725-e3pazjdi 84 52 interacting interact VBG cord-252725-e3pazjdi 84 53 with with IN cord-252725-e3pazjdi 84 54 the the DT cord-252725-e3pazjdi 84 55 HIV-1 HIV-1 NNP cord-252725-e3pazjdi 84 56 envelope envelope NN cord-252725-e3pazjdi 84 57 glycoprotein glycoprotein NN cord-252725-e3pazjdi 84 58 [ [ -LRB- cord-252725-e3pazjdi 84 59 60 60 CD cord-252725-e3pazjdi 84 60 ] ] -RRB- cord-252725-e3pazjdi 84 61 . . . cord-252725-e3pazjdi 85 1 Methanolic Methanolic NNP cord-252725-e3pazjdi 85 2 extract extract NN cord-252725-e3pazjdi 85 3 of of IN cord-252725-e3pazjdi 85 4 Capparissinaica Capparissinaica NNP cord-252725-e3pazjdi 85 5 Veill Veill NNP cord-252725-e3pazjdi 85 6 , , , cord-252725-e3pazjdi 85 7 which which WDT cord-252725-e3pazjdi 85 8 consists consist VBZ cord-252725-e3pazjdi 85 9 mainly mainly RB cord-252725-e3pazjdi 85 10 of of IN cord-252725-e3pazjdi 85 11 rutin rutin NN cord-252725-e3pazjdi 85 12 , , , cord-252725-e3pazjdi 85 13 was be VBD cord-252725-e3pazjdi 85 14 tested test VBN cord-252725-e3pazjdi 85 15 for for IN cord-252725-e3pazjdi 85 16 its -PRON- PRP$ cord-252725-e3pazjdi 85 17 in in IN cord-252725-e3pazjdi 85 18 vitro vitro FW cord-252725-e3pazjdi 85 19 antiviral antiviral JJ cord-252725-e3pazjdi 85 20 activity activity NN cord-252725-e3pazjdi 85 21 against against IN cord-252725-e3pazjdi 85 22 avian avian JJ cord-252725-e3pazjdi 85 23 influenza influenza NN cord-252725-e3pazjdi 85 24 strain strain VB cord-252725-e3pazjdi 85 25 H5N1 H5N1 NNP cord-252725-e3pazjdi 85 26 using use VBG cord-252725-e3pazjdi 85 27 plaque plaque NN cord-252725-e3pazjdi 85 28 inhibition inhibition NN cord-252725-e3pazjdi 85 29 assay assay NN cord-252725-e3pazjdi 85 30 in in IN cord-252725-e3pazjdi 85 31 Madin Madin NNP cord-252725-e3pazjdi 85 32 - - HYPH cord-252725-e3pazjdi 85 33 Darby Darby NNP cord-252725-e3pazjdi 85 34 canine canine JJ cord-252725-e3pazjdi 85 35 kidney kidney NN cord-252725-e3pazjdi 85 36 . . . cord-252725-e3pazjdi 86 1 The the DT cord-252725-e3pazjdi 86 2 test test NN cord-252725-e3pazjdi 86 3 showed show VBD cord-252725-e3pazjdi 86 4 a a DT cord-252725-e3pazjdi 86 5 significant significant JJ cord-252725-e3pazjdi 86 6 inhibition inhibition NN cord-252725-e3pazjdi 86 7 of of IN cord-252725-e3pazjdi 86 8 the the DT cord-252725-e3pazjdi 86 9 virus virus NN cord-252725-e3pazjdi 86 10 by by IN cord-252725-e3pazjdi 86 11 about about IN cord-252725-e3pazjdi 86 12 73 73 CD cord-252725-e3pazjdi 86 13 % % NN cord-252725-e3pazjdi 86 14 [ [ -LRB- cord-252725-e3pazjdi 86 15 61 61 CD cord-252725-e3pazjdi 86 16 ] ] -RRB- cord-252725-e3pazjdi 86 17 . . . cord-252725-e3pazjdi 87 1 Moreover moreover RB cord-252725-e3pazjdi 87 2 , , , cord-252725-e3pazjdi 87 3 rutin rutin NN cord-252725-e3pazjdi 87 4 , , , cord-252725-e3pazjdi 87 5 isolated isolate VBN cord-252725-e3pazjdi 87 6 from from IN cord-252725-e3pazjdi 87 7 Prunus Prunus NNP cord-252725-e3pazjdi 87 8 domestica domestica NN cord-252725-e3pazjdi 87 9 was be VBD cord-252725-e3pazjdi 87 10 suggested suggest VBN cord-252725-e3pazjdi 87 11 as as IN cord-252725-e3pazjdi 87 12 a a DT cord-252725-e3pazjdi 87 13 strong strong JJ cord-252725-e3pazjdi 87 14 inhibitor inhibitor NN cord-252725-e3pazjdi 87 15 of of IN cord-252725-e3pazjdi 87 16 hepatitis hepatitis NN cord-252725-e3pazjdi 87 17 C C NNP cord-252725-e3pazjdi 87 18 virus virus NN cord-252725-e3pazjdi 87 19 ( ( -LRB- cord-252725-e3pazjdi 87 20 HCV HCV NNP cord-252725-e3pazjdi 87 21 ) ) -RRB- cord-252725-e3pazjdi 87 22 entry entry NN cord-252725-e3pazjdi 87 23 ; ; : cord-252725-e3pazjdi 87 24 rutin rutin NN cord-252725-e3pazjdi 87 25 inhibits inhibit VBZ cord-252725-e3pazjdi 87 26 the the DT cord-252725-e3pazjdi 87 27 early early JJ cord-252725-e3pazjdi 87 28 entry entry NN cord-252725-e3pazjdi 87 29 stage stage NN cord-252725-e3pazjdi 87 30 of of IN cord-252725-e3pazjdi 87 31 HCV HCV NNP cord-252725-e3pazjdi 87 32 lifecycle lifecycle NN cord-252725-e3pazjdi 87 33 by by IN cord-252725-e3pazjdi 87 34 directly directly RB cord-252725-e3pazjdi 87 35 acting act VBG cord-252725-e3pazjdi 87 36 on on IN cord-252725-e3pazjdi 87 37 the the DT cord-252725-e3pazjdi 87 38 viral viral JJ cord-252725-e3pazjdi 87 39 particle particle NN cord-252725-e3pazjdi 87 40 [ [ -LRB- cord-252725-e3pazjdi 87 41 62 62 CD cord-252725-e3pazjdi 87 42 ] ] -RRB- cord-252725-e3pazjdi 87 43 . . . cord-252725-e3pazjdi 88 1 Based base VBN cord-252725-e3pazjdi 88 2 on on IN cord-252725-e3pazjdi 88 3 the the DT cord-252725-e3pazjdi 88 4 above above RB cord-252725-e3pazjdi 88 5 summarized summarize VBN cord-252725-e3pazjdi 88 6 effects effect NNS cord-252725-e3pazjdi 88 7 of of IN cord-252725-e3pazjdi 88 8 rutin rutin NN cord-252725-e3pazjdi 88 9 , , , cord-252725-e3pazjdi 88 10 this this DT cord-252725-e3pazjdi 88 11 flavonoid flavonoid NN cord-252725-e3pazjdi 88 12 appears appear VBZ cord-252725-e3pazjdi 88 13 to to TO cord-252725-e3pazjdi 88 14 be be VB cord-252725-e3pazjdi 88 15 a a DT cord-252725-e3pazjdi 88 16 potent potent JJ cord-252725-e3pazjdi 88 17 component component NN cord-252725-e3pazjdi 88 18 that that WDT cord-252725-e3pazjdi 88 19 could could MD cord-252725-e3pazjdi 88 20 be be VB cord-252725-e3pazjdi 88 21 considered consider VBN cord-252725-e3pazjdi 88 22 in in IN cord-252725-e3pazjdi 88 23 the the DT cord-252725-e3pazjdi 88 24 treatment treatment NN cord-252725-e3pazjdi 88 25 of of IN cord-252725-e3pazjdi 88 26 several several JJ cord-252725-e3pazjdi 88 27 viral viral JJ cord-252725-e3pazjdi 88 28 infectious infectious JJ cord-252725-e3pazjdi 88 29 diseases disease NNS cord-252725-e3pazjdi 88 30 . . . cord-252725-e3pazjdi 89 1 Resveratrol Resveratrol NNP cord-252725-e3pazjdi 89 2 ( ( -LRB- cord-252725-e3pazjdi 89 3 3,5,4′-trihydroxy 3,5,4′-trihydroxy NNP cord-252725-e3pazjdi 89 4 - - HYPH cord-252725-e3pazjdi 89 5 trans trans NNP cord-252725-e3pazjdi 89 6 - - JJ cord-252725-e3pazjdi 89 7 stilbene stilbene JJ cord-252725-e3pazjdi 89 8 ) ) -RRB- cord-252725-e3pazjdi 90 1 ( ( -LRB- cord-252725-e3pazjdi 90 2 Fig Fig NNP cord-252725-e3pazjdi 90 3 . . NNP cord-252725-e3pazjdi 90 4 4 4 CD cord-252725-e3pazjdi 90 5 ) ) -RRB- cord-252725-e3pazjdi 90 6 , , , cord-252725-e3pazjdi 90 7 a a DT cord-252725-e3pazjdi 90 8 natural natural JJ cord-252725-e3pazjdi 90 9 polyphenol polyphenol NN cord-252725-e3pazjdi 90 10 non non JJ cord-252725-e3pazjdi 90 11 - - JJ cord-252725-e3pazjdi 90 12 flavonoid flavonoid JJ cord-252725-e3pazjdi 90 13 compound compound NN cord-252725-e3pazjdi 90 14 produced produce VBN cord-252725-e3pazjdi 90 15 by by IN cord-252725-e3pazjdi 90 16 several several JJ cord-252725-e3pazjdi 90 17 plants plant NNS cord-252725-e3pazjdi 90 18 in in IN cord-252725-e3pazjdi 90 19 response response NN cord-252725-e3pazjdi 90 20 to to IN cord-252725-e3pazjdi 90 21 injury injury NN cord-252725-e3pazjdi 90 22 or or CC cord-252725-e3pazjdi 90 23 invasion invasion NN cord-252725-e3pazjdi 90 24 by by IN cord-252725-e3pazjdi 90 25 pathogens pathogen NNS cord-252725-e3pazjdi 90 26 , , , cord-252725-e3pazjdi 90 27 such such JJ cord-252725-e3pazjdi 90 28 as as IN cord-252725-e3pazjdi 90 29 bacteria bacteria NNS cord-252725-e3pazjdi 90 30 and and CC cord-252725-e3pazjdi 90 31 fungi fungus NNS cord-252725-e3pazjdi 90 32 [ [ -LRB- cord-252725-e3pazjdi 90 33 63 63 CD cord-252725-e3pazjdi 90 34 ] ] -RRB- cord-252725-e3pazjdi 90 35 . . . cord-252725-e3pazjdi 91 1 Resveratrol resveratrol NN cord-252725-e3pazjdi 91 2 is be VBZ cord-252725-e3pazjdi 91 3 mainly mainly RB cord-252725-e3pazjdi 91 4 present present JJ cord-252725-e3pazjdi 91 5 in in IN cord-252725-e3pazjdi 91 6 pigments pigment NNS cord-252725-e3pazjdi 91 7 of of IN cord-252725-e3pazjdi 91 8 several several JJ cord-252725-e3pazjdi 91 9 fruits fruit NNS cord-252725-e3pazjdi 91 10 and and CC cord-252725-e3pazjdi 91 11 vegetables vegetable NNS cord-252725-e3pazjdi 91 12 , , , cord-252725-e3pazjdi 91 13 for for IN cord-252725-e3pazjdi 91 14 instance instance NN cord-252725-e3pazjdi 91 15 rhubarb rhubarb NN cord-252725-e3pazjdi 91 16 , , , cord-252725-e3pazjdi 91 17 blueberries blueberry NNS cord-252725-e3pazjdi 91 18 , , , cord-252725-e3pazjdi 91 19 many many JJ cord-252725-e3pazjdi 91 20 red red JJ cord-252725-e3pazjdi 91 21 grapes grape NNS cord-252725-e3pazjdi 91 22 , , , cord-252725-e3pazjdi 91 23 raspberries raspberry NNS cord-252725-e3pazjdi 91 24 , , , cord-252725-e3pazjdi 91 25 mulberries mulberry NNS cord-252725-e3pazjdi 91 26 , , , cord-252725-e3pazjdi 91 27 peanuts peanut NNS cord-252725-e3pazjdi 91 28 and and CC cord-252725-e3pazjdi 91 29 also also RB cord-252725-e3pazjdi 91 30 in in IN cord-252725-e3pazjdi 91 31 dark dark JJ cord-252725-e3pazjdi 91 32 chocolate chocolate NN cord-252725-e3pazjdi 91 33 and and CC cord-252725-e3pazjdi 91 34 red red JJ cord-252725-e3pazjdi 91 35 wine wine NN cord-252725-e3pazjdi 91 36 . . . cord-252725-e3pazjdi 92 1 Resveratrol resveratrol NN cord-252725-e3pazjdi 92 2 received receive VBD cord-252725-e3pazjdi 92 3 intensive intensive JJ cord-252725-e3pazjdi 92 4 studies study NNS cord-252725-e3pazjdi 92 5 due due IN cord-252725-e3pazjdi 92 6 to to IN cord-252725-e3pazjdi 92 7 its -PRON- PRP$ cord-252725-e3pazjdi 92 8 diverse diverse JJ cord-252725-e3pazjdi 92 9 biological biological JJ cord-252725-e3pazjdi 92 10 activities activity NNS cord-252725-e3pazjdi 92 11 , , , cord-252725-e3pazjdi 92 12 including include VBG cord-252725-e3pazjdi 92 13 , , , cord-252725-e3pazjdi 92 14 antioxidant antioxidant JJ cord-252725-e3pazjdi 92 15 , , , cord-252725-e3pazjdi 92 16 anti anti JJ cord-252725-e3pazjdi 92 17 - - JJ cord-252725-e3pazjdi 92 18 inflammatory inflammatory JJ cord-252725-e3pazjdi 92 19 , , , cord-252725-e3pazjdi 92 20 antitumor antitumor JJ cord-252725-e3pazjdi 92 21 , , , cord-252725-e3pazjdi 92 22 cardio cardio JJ cord-252725-e3pazjdi 92 23 protective protective JJ cord-252725-e3pazjdi 92 24 , , , cord-252725-e3pazjdi 92 25 and and CC cord-252725-e3pazjdi 92 26 antiviral antiviral JJ cord-252725-e3pazjdi 92 27 activity activity NN cord-252725-e3pazjdi 92 28 , , , cord-252725-e3pazjdi 92 29 it -PRON- PRP cord-252725-e3pazjdi 92 30 also also RB cord-252725-e3pazjdi 92 31 possesses possess VBZ cord-252725-e3pazjdi 92 32 other other JJ cord-252725-e3pazjdi 92 33 properties property NNS cord-252725-e3pazjdi 92 34 such such JJ cord-252725-e3pazjdi 92 35 as as IN cord-252725-e3pazjdi 92 36 a a DT cord-252725-e3pazjdi 92 37 preventive preventive JJ cord-252725-e3pazjdi 92 38 and and CC cord-252725-e3pazjdi 92 39 defensive defensive JJ cord-252725-e3pazjdi 92 40 mean mean NN cord-252725-e3pazjdi 92 41 towards towards IN cord-252725-e3pazjdi 92 42 obesity obesity NN cord-252725-e3pazjdi 92 43 , , , cord-252725-e3pazjdi 92 44 diabetes diabetes NN cord-252725-e3pazjdi 92 45 and and CC cord-252725-e3pazjdi 92 46 metabolic metabolic JJ cord-252725-e3pazjdi 92 47 syndrome syndrome NN cord-252725-e3pazjdi 92 48 ; ; : cord-252725-e3pazjdi 92 49 it -PRON- PRP cord-252725-e3pazjdi 92 50 can can MD cord-252725-e3pazjdi 92 51 also also RB cord-252725-e3pazjdi 92 52 beneficially beneficially RB cord-252725-e3pazjdi 92 53 regulate regulate VB cord-252725-e3pazjdi 92 54 the the DT cord-252725-e3pazjdi 92 55 immune immune JJ cord-252725-e3pazjdi 92 56 system system NN cord-252725-e3pazjdi 92 57 [ [ -LRB- cord-252725-e3pazjdi 92 58 64 64 CD cord-252725-e3pazjdi 92 59 , , , cord-252725-e3pazjdi 92 60 65 65 CD cord-252725-e3pazjdi 92 61 ] ] -RRB- cord-252725-e3pazjdi 92 62 . . . cord-252725-e3pazjdi 93 1 Resveratrol resveratrol NN cord-252725-e3pazjdi 93 2 can can MD cord-252725-e3pazjdi 93 3 affect affect VB cord-252725-e3pazjdi 93 4 several several JJ cord-252725-e3pazjdi 93 5 pathways pathway NNS cord-252725-e3pazjdi 93 6 , , , cord-252725-e3pazjdi 93 7 which which WDT cord-252725-e3pazjdi 93 8 regulate regulate VBP cord-252725-e3pazjdi 93 9 inflammation inflammation NN cord-252725-e3pazjdi 93 10 , , , cord-252725-e3pazjdi 93 11 immune immune JJ cord-252725-e3pazjdi 93 12 response response NN cord-252725-e3pazjdi 93 13 , , , cord-252725-e3pazjdi 93 14 and and CC cord-252725-e3pazjdi 93 15 cellular cellular JJ cord-252725-e3pazjdi 93 16 response response NN cord-252725-e3pazjdi 93 17 to to IN cord-252725-e3pazjdi 93 18 a a DT cord-252725-e3pazjdi 93 19 variety variety NN cord-252725-e3pazjdi 93 20 of of IN cord-252725-e3pazjdi 93 21 stimuli stimulus NNS cord-252725-e3pazjdi 93 22 [ [ -LRB- cord-252725-e3pazjdi 93 23 66 66 CD cord-252725-e3pazjdi 93 24 ] ] -RRB- cord-252725-e3pazjdi 93 25 . . . cord-252725-e3pazjdi 94 1 In in IN cord-252725-e3pazjdi 94 2 fact fact NN cord-252725-e3pazjdi 94 3 , , , cord-252725-e3pazjdi 94 4 resveratrol resveratrol NN cord-252725-e3pazjdi 94 5 has have VBZ cord-252725-e3pazjdi 94 6 become become VBN cord-252725-e3pazjdi 94 7 a a DT cord-252725-e3pazjdi 94 8 household household NN cord-252725-e3pazjdi 94 9 word word NN cord-252725-e3pazjdi 94 10 in in IN cord-252725-e3pazjdi 94 11 the the DT cord-252725-e3pazjdi 94 12 context context NN cord-252725-e3pazjdi 94 13 of of IN cord-252725-e3pazjdi 94 14 a a DT cord-252725-e3pazjdi 94 15 natural natural JJ cord-252725-e3pazjdi 94 16 product product NN cord-252725-e3pazjdi 94 17 that that WDT cord-252725-e3pazjdi 94 18 has have VBZ cord-252725-e3pazjdi 94 19 the the DT cord-252725-e3pazjdi 94 20 potential potential NN cord-252725-e3pazjdi 94 21 of of IN cord-252725-e3pazjdi 94 22 promoting promote VBG cord-252725-e3pazjdi 94 23 good good JJ cord-252725-e3pazjdi 94 24 health health NN cord-252725-e3pazjdi 94 25 [ [ -LRB- cord-252725-e3pazjdi 94 26 67 67 CD cord-252725-e3pazjdi 94 27 ] ] -RRB- cord-252725-e3pazjdi 94 28 . . . cord-252725-e3pazjdi 95 1 In in IN cord-252725-e3pazjdi 95 2 fact fact NN cord-252725-e3pazjdi 95 3 , , , cord-252725-e3pazjdi 95 4 several several JJ cord-252725-e3pazjdi 95 5 RNA RNA NNP cord-252725-e3pazjdi 95 6 virus virus NN cord-252725-e3pazjdi 95 7 replications replication NNS cord-252725-e3pazjdi 95 8 have have VBP cord-252725-e3pazjdi 95 9 been be VBN cord-252725-e3pazjdi 95 10 shown show VBN cord-252725-e3pazjdi 95 11 to to TO cord-252725-e3pazjdi 95 12 be be VB cord-252725-e3pazjdi 95 13 inhibited inhibit VBN cord-252725-e3pazjdi 95 14 by by IN cord-252725-e3pazjdi 95 15 resveratrol resveratrol NN cord-252725-e3pazjdi 95 16 including include VBG cord-252725-e3pazjdi 95 17 the the DT cord-252725-e3pazjdi 95 18 influenza influenza NN cord-252725-e3pazjdi 95 19 virus virus NN cord-252725-e3pazjdi 95 20 and and CC cord-252725-e3pazjdi 95 21 rhinoviruses rhinovirus NNS cord-252725-e3pazjdi 95 22 , , , cord-252725-e3pazjdi 95 23 which which WDT cord-252725-e3pazjdi 95 24 are be VBP cord-252725-e3pazjdi 95 25 , , , cord-252725-e3pazjdi 95 26 the the DT cord-252725-e3pazjdi 95 27 main main JJ cord-252725-e3pazjdi 95 28 cause cause NN cord-252725-e3pazjdi 95 29 of of IN cord-252725-e3pazjdi 95 30 common common JJ cord-252725-e3pazjdi 95 31 colds cold NNS cord-252725-e3pazjdi 95 32 [ [ -LRB- cord-252725-e3pazjdi 95 33 68 68 CD cord-252725-e3pazjdi 95 34 ] ] -RRB- cord-252725-e3pazjdi 95 35 . . . cord-252725-e3pazjdi 96 1 Resveratrol resveratrol NN cord-252725-e3pazjdi 96 2 could could MD cord-252725-e3pazjdi 96 3 be be VB cord-252725-e3pazjdi 96 4 used use VBN cord-252725-e3pazjdi 96 5 to to TO cord-252725-e3pazjdi 96 6 prevent prevent VB cord-252725-e3pazjdi 96 7 respiratory respiratory JJ cord-252725-e3pazjdi 96 8 infections infection NNS cord-252725-e3pazjdi 96 9 in in IN cord-252725-e3pazjdi 96 10 children child NNS cord-252725-e3pazjdi 96 11 by by IN cord-252725-e3pazjdi 96 12 a a DT cord-252725-e3pazjdi 96 13 significant significant JJ cord-252725-e3pazjdi 96 14 reduction reduction NN cord-252725-e3pazjdi 96 15 in in IN cord-252725-e3pazjdi 96 16 nasal nasal JJ cord-252725-e3pazjdi 96 17 obstruction obstruction NN cord-252725-e3pazjdi 96 18 , , , cord-252725-e3pazjdi 96 19 rhinorrhea rhinorrhea NN cord-252725-e3pazjdi 96 20 , , , cord-252725-e3pazjdi 96 21 sneezing sneezing NN cord-252725-e3pazjdi 96 22 , , , cord-252725-e3pazjdi 96 23 cough cough NN cord-252725-e3pazjdi 96 24 , , , cord-252725-e3pazjdi 96 25 fever fever NN cord-252725-e3pazjdi 96 26 and and CC cord-252725-e3pazjdi 96 27 medication medication NN cord-252725-e3pazjdi 96 28 usage usage NN cord-252725-e3pazjdi 96 29 [ [ -LRB- cord-252725-e3pazjdi 96 30 69 69 CD cord-252725-e3pazjdi 96 31 ] ] -RRB- cord-252725-e3pazjdi 96 32 . . . cord-252725-e3pazjdi 97 1 Respiratory respiratory JJ cord-252725-e3pazjdi 97 2 syncytial syncytial JJ cord-252725-e3pazjdi 97 3 virus virus NN cord-252725-e3pazjdi 97 4 ( ( -LRB- cord-252725-e3pazjdi 97 5 RSV RSV NNP cord-252725-e3pazjdi 97 6 ) ) -RRB- cord-252725-e3pazjdi 97 7 which which WDT cord-252725-e3pazjdi 97 8 is be VBZ cord-252725-e3pazjdi 97 9 the the DT cord-252725-e3pazjdi 97 10 main main JJ cord-252725-e3pazjdi 97 11 cause cause NN cord-252725-e3pazjdi 97 12 of of IN cord-252725-e3pazjdi 97 13 severe severe JJ cord-252725-e3pazjdi 97 14 , , , cord-252725-e3pazjdi 97 15 lower low JJR cord-252725-e3pazjdi 97 16 respiratory respiratory JJ cord-252725-e3pazjdi 97 17 tract tract NN cord-252725-e3pazjdi 97 18 infections infection NNS cord-252725-e3pazjdi 97 19 in in IN cord-252725-e3pazjdi 97 20 infants infant NNS cord-252725-e3pazjdi 97 21 was be VBD cord-252725-e3pazjdi 97 22 found find VBN cord-252725-e3pazjdi 97 23 to to TO cord-252725-e3pazjdi 97 24 be be VB cord-252725-e3pazjdi 97 25 improved improve VBN cord-252725-e3pazjdi 97 26 by by IN cord-252725-e3pazjdi 97 27 resveratrol resveratrol NN cord-252725-e3pazjdi 97 28 intake intake NN cord-252725-e3pazjdi 97 29 which which WDT cord-252725-e3pazjdi 97 30 reduces reduce VBZ cord-252725-e3pazjdi 97 31 IFN IFN NNP cord-252725-e3pazjdi 97 32 - - HYPH cord-252725-e3pazjdi 97 33 γ γ NN cord-252725-e3pazjdi 97 34 levels level NNS cord-252725-e3pazjdi 97 35 associated associate VBN cord-252725-e3pazjdi 97 36 with with IN cord-252725-e3pazjdi 97 37 RSV RSV NNP cord-252725-e3pazjdi 97 38 - - HYPH cord-252725-e3pazjdi 97 39 mediated mediate VBN cord-252725-e3pazjdi 97 40 airway airway NN cord-252725-e3pazjdi 97 41 inflammation inflammation NN cord-252725-e3pazjdi 97 42 [ [ -LRB- cord-252725-e3pazjdi 97 43 70 70 CD cord-252725-e3pazjdi 97 44 ] ] -RRB- cord-252725-e3pazjdi 97 45 . . . cord-252725-e3pazjdi 98 1 Moreover moreover RB cord-252725-e3pazjdi 98 2 , , , cord-252725-e3pazjdi 98 3 resveratrol resveratrol NN cord-252725-e3pazjdi 98 4 was be VBD cord-252725-e3pazjdi 98 5 found find VBN cord-252725-e3pazjdi 98 6 to to TO cord-252725-e3pazjdi 98 7 be be VB cord-252725-e3pazjdi 98 8 a a DT cord-252725-e3pazjdi 98 9 potential potential JJ cord-252725-e3pazjdi 98 10 antiviral antiviral JJ cord-252725-e3pazjdi 98 11 agent agent NN cord-252725-e3pazjdi 98 12 in in IN cord-252725-e3pazjdi 98 13 vitro vitro FW cord-252725-e3pazjdi 98 14 against against IN cord-252725-e3pazjdi 98 15 MERS MERS NNP cord-252725-e3pazjdi 98 16 - - HYPH cord-252725-e3pazjdi 98 17 CoV CoV NNP cord-252725-e3pazjdi 98 18 infection infection NN cord-252725-e3pazjdi 98 19 [ [ -LRB- cord-252725-e3pazjdi 98 20 71 71 CD cord-252725-e3pazjdi 98 21 ] ] -RRB- cord-252725-e3pazjdi 98 22 . . . cord-252725-e3pazjdi 99 1 Moreover moreover RB cord-252725-e3pazjdi 99 2 , , , cord-252725-e3pazjdi 99 3 stilbene stilbene JJ cord-252725-e3pazjdi 99 4 derivatives derivative NNS cord-252725-e3pazjdi 99 5 to to IN cord-252725-e3pazjdi 99 6 which which WDT cord-252725-e3pazjdi 99 7 resveratrol resveratrol NN cord-252725-e3pazjdi 99 8 belongs belong VBZ cord-252725-e3pazjdi 99 9 were be VBD cord-252725-e3pazjdi 99 10 shown show VBN cord-252725-e3pazjdi 99 11 to to TO cord-252725-e3pazjdi 99 12 totally totally RB cord-252725-e3pazjdi 99 13 inhibit inhibit VB cord-252725-e3pazjdi 99 14 the the DT cord-252725-e3pazjdi 99 15 antiviral antiviral JJ cord-252725-e3pazjdi 99 16 activities activity NNS cord-252725-e3pazjdi 99 17 of of IN cord-252725-e3pazjdi 99 18 SARS SARS NNP cord-252725-e3pazjdi 99 19 - - HYPH cord-252725-e3pazjdi 99 20 CoV CoV NNP cord-252725-e3pazjdi 99 21 [ [ -LRB- cord-252725-e3pazjdi 99 22 72 72 CD cord-252725-e3pazjdi 99 23 ] ] -RRB- cord-252725-e3pazjdi 99 24 . . . cord-252725-e3pazjdi 100 1 Due due IN cord-252725-e3pazjdi 100 2 to to IN cord-252725-e3pazjdi 100 3 the the DT cord-252725-e3pazjdi 100 4 numerous numerous JJ cord-252725-e3pazjdi 100 5 beneficial beneficial JJ cord-252725-e3pazjdi 100 6 effects effect NNS cord-252725-e3pazjdi 100 7 of of IN cord-252725-e3pazjdi 100 8 resveratrol resveratrol NN cord-252725-e3pazjdi 100 9 and and CC cord-252725-e3pazjdi 100 10 its -PRON- PRP$ cord-252725-e3pazjdi 100 11 ability ability NN cord-252725-e3pazjdi 100 12 to to TO cord-252725-e3pazjdi 100 13 interact interact VB cord-252725-e3pazjdi 100 14 with with IN cord-252725-e3pazjdi 100 15 several several JJ cord-252725-e3pazjdi 100 16 cellular cellular JJ cord-252725-e3pazjdi 100 17 pathways pathway NNS cord-252725-e3pazjdi 100 18 , , , cord-252725-e3pazjdi 100 19 it -PRON- PRP cord-252725-e3pazjdi 100 20 could could MD cord-252725-e3pazjdi 100 21 be be VB cord-252725-e3pazjdi 100 22 selected select VBN cord-252725-e3pazjdi 100 23 as as IN cord-252725-e3pazjdi 100 24 a a DT cord-252725-e3pazjdi 100 25 potential potential JJ cord-252725-e3pazjdi 100 26 candidate candidate NN cord-252725-e3pazjdi 100 27 for for IN cord-252725-e3pazjdi 100 28 treatment treatment NN cord-252725-e3pazjdi 100 29 of of IN cord-252725-e3pazjdi 100 30 COVID-19 covid-19 JJ cord-252725-e3pazjdi 100 31 infection infection NN cord-252725-e3pazjdi 100 32 and and CC cord-252725-e3pazjdi 100 33 its -PRON- PRP$ cord-252725-e3pazjdi 100 34 related related JJ cord-252725-e3pazjdi 100 35 symptoms symptom NNS cord-252725-e3pazjdi 100 36 . . . cord-252725-e3pazjdi 100 37 _SP cord-252725-e3pazjdi 101 1 Kaempferol Kaempferol NNP cord-252725-e3pazjdi 101 2 also also RB cord-252725-e3pazjdi 101 3 named name VBD cord-252725-e3pazjdi 101 4 3,4′,5,7-tetrahydroxyflavone 3,4′,5,7-tetrahydroxyflavone CD cord-252725-e3pazjdi 101 5 ( ( -LRB- cord-252725-e3pazjdi 101 6 Fig Fig NNP cord-252725-e3pazjdi 101 7 . . . cord-252725-e3pazjdi 101 8 5 5 LS cord-252725-e3pazjdi 101 9 ) ) -RRB- cord-252725-e3pazjdi 101 10 is be VBZ cord-252725-e3pazjdi 101 11 a a DT cord-252725-e3pazjdi 101 12 widespread widespread JJ cord-252725-e3pazjdi 101 13 natural natural JJ cord-252725-e3pazjdi 101 14 flavonoids flavonoid NNS cord-252725-e3pazjdi 101 15 found find VBN cord-252725-e3pazjdi 101 16 in in IN cord-252725-e3pazjdi 101 17 a a DT cord-252725-e3pazjdi 101 18 variety variety NN cord-252725-e3pazjdi 101 19 of of IN cord-252725-e3pazjdi 101 20 medicinal medicinal JJ cord-252725-e3pazjdi 101 21 plants plant NNS cord-252725-e3pazjdi 101 22 , , , cord-252725-e3pazjdi 101 23 fruits fruit NNS cord-252725-e3pazjdi 101 24 , , , cord-252725-e3pazjdi 101 25 vegetables vegetable NNS cord-252725-e3pazjdi 101 26 and and CC cord-252725-e3pazjdi 101 27 herbs herb NNS cord-252725-e3pazjdi 101 28 including include VBG cord-252725-e3pazjdi 101 29 grapes grape NNS cord-252725-e3pazjdi 101 30 , , , cord-252725-e3pazjdi 101 31 apples apple NNS cord-252725-e3pazjdi 101 32 , , , cord-252725-e3pazjdi 101 33 strawberries strawberry NNS cord-252725-e3pazjdi 101 34 , , , cord-252725-e3pazjdi 101 35 tomatoes tomato NNS cord-252725-e3pazjdi 101 36 , , , cord-252725-e3pazjdi 101 37 broccoli broccoli NN cord-252725-e3pazjdi 101 38 , , , cord-252725-e3pazjdi 101 39 tea tea NN cord-252725-e3pazjdi 101 40 , , , cord-252725-e3pazjdi 101 41 spinach spinach NN cord-252725-e3pazjdi 101 42 , , , cord-252725-e3pazjdi 101 43 beans bean NNS cord-252725-e3pazjdi 101 44 , , , cord-252725-e3pazjdi 101 45 kale kale NN cord-252725-e3pazjdi 101 46 , , , cord-252725-e3pazjdi 101 47 leeks leek NNS cord-252725-e3pazjdi 101 48 , , , cord-252725-e3pazjdi 101 49 ginkgo ginkgo NN cord-252725-e3pazjdi 101 50 biloba biloba NN cord-252725-e3pazjdi 101 51 leaves leave VBZ cord-252725-e3pazjdi 101 52 , , , cord-252725-e3pazjdi 101 53 Tilia Tilia NNP cord-252725-e3pazjdi 101 54 spp spp NNS cord-252725-e3pazjdi 101 55 , , , cord-252725-e3pazjdi 101 56 Equisetum Equisetum NNP cord-252725-e3pazjdi 101 57 spp spp NNS cord-252725-e3pazjdi 101 58 , , , cord-252725-e3pazjdi 101 59 Moringa Moringa NNP cord-252725-e3pazjdi 101 60 oleifera oleifera NN cord-252725-e3pazjdi 101 61 , , , cord-252725-e3pazjdi 101 62 Sophora Sophora NNP cord-252725-e3pazjdi 101 63 japonica japonica NN cord-252725-e3pazjdi 101 64 and and CC cord-252725-e3pazjdi 101 65 propolis propolis NN cord-252725-e3pazjdi 101 66 [ [ -LRB- cord-252725-e3pazjdi 101 67 73 73 CD cord-252725-e3pazjdi 101 68 , , , cord-252725-e3pazjdi 101 69 74 74 CD cord-252725-e3pazjdi 101 70 ] ] -RRB- cord-252725-e3pazjdi 101 71 . . . cord-252725-e3pazjdi 102 1 Kaempferol Kaempferol NNP cord-252725-e3pazjdi 102 2 has have VBZ cord-252725-e3pazjdi 102 3 a a DT cord-252725-e3pazjdi 102 4 wide wide JJ cord-252725-e3pazjdi 102 5 variety variety NN cord-252725-e3pazjdi 102 6 of of IN cord-252725-e3pazjdi 102 7 pharmacological pharmacological JJ cord-252725-e3pazjdi 102 8 activities activity NNS cord-252725-e3pazjdi 102 9 including include VBG cord-252725-e3pazjdi 102 10 antioxidant antioxidant JJ cord-252725-e3pazjdi 102 11 , , , cord-252725-e3pazjdi 102 12 anti anti JJ cord-252725-e3pazjdi 102 13 - - JJ cord-252725-e3pazjdi 102 14 inflammatory inflammatory JJ cord-252725-e3pazjdi 102 15 , , , cord-252725-e3pazjdi 102 16 antimicrobial antimicrobial JJ cord-252725-e3pazjdi 102 17 , , , cord-252725-e3pazjdi 102 18 anticancer anticancer JJ cord-252725-e3pazjdi 102 19 , , , cord-252725-e3pazjdi 102 20 cardioprotective cardioprotective JJ cord-252725-e3pazjdi 102 21 , , , cord-252725-e3pazjdi 102 22 neuroprotective neuroprotective JJ cord-252725-e3pazjdi 102 23 , , , cord-252725-e3pazjdi 102 24 antidiabetic antidiabetic JJ cord-252725-e3pazjdi 102 25 , , , cord-252725-e3pazjdi 102 26 anti anti JJ cord-252725-e3pazjdi 102 27 - - JJ cord-252725-e3pazjdi 102 28 osteoporotic osteoporotic JJ cord-252725-e3pazjdi 102 29 , , , cord-252725-e3pazjdi 102 30 estrogenic estrogenic JJ cord-252725-e3pazjdi 102 31 / / SYM cord-252725-e3pazjdi 102 32 antiestrogenic antiestrogenic NNP cord-252725-e3pazjdi 102 33 , , , cord-252725-e3pazjdi 102 34 anxiolytic anxiolytic JJ cord-252725-e3pazjdi 102 35 , , , cord-252725-e3pazjdi 102 36 analgesic analgesic JJ cord-252725-e3pazjdi 102 37 , , , cord-252725-e3pazjdi 102 38 and and CC cord-252725-e3pazjdi 102 39 antiallergic antiallergic NN cord-252725-e3pazjdi 102 40 activities activity NNS cord-252725-e3pazjdi 102 41 [ [ -LRB- cord-252725-e3pazjdi 102 42 75 75 CD cord-252725-e3pazjdi 102 43 ] ] -RRB- cord-252725-e3pazjdi 102 44 . . . cord-252725-e3pazjdi 103 1 In in IN cord-252725-e3pazjdi 103 2 fact fact NN cord-252725-e3pazjdi 103 3 , , , cord-252725-e3pazjdi 103 4 many many JJ cord-252725-e3pazjdi 103 5 studies study NNS cord-252725-e3pazjdi 103 6 demonstrated demonstrate VBD cord-252725-e3pazjdi 103 7 the the DT cord-252725-e3pazjdi 103 8 beneficial beneficial JJ cord-252725-e3pazjdi 103 9 effects effect NNS cord-252725-e3pazjdi 103 10 of of IN cord-252725-e3pazjdi 103 11 dietary dietary JJ cord-252725-e3pazjdi 103 12 kaempferol kaempferol NN cord-252725-e3pazjdi 103 13 in in IN cord-252725-e3pazjdi 103 14 reducing reduce VBG cord-252725-e3pazjdi 103 15 the the DT cord-252725-e3pazjdi 103 16 risk risk NN cord-252725-e3pazjdi 103 17 of of IN cord-252725-e3pazjdi 103 18 chronic chronic JJ cord-252725-e3pazjdi 103 19 diseases disease NNS cord-252725-e3pazjdi 103 20 by by IN cord-252725-e3pazjdi 103 21 augmenting augment VBG cord-252725-e3pazjdi 103 22 the the DT cord-252725-e3pazjdi 103 23 body body NN cord-252725-e3pazjdi 103 24 's 's POS cord-252725-e3pazjdi 103 25 antioxidant antioxidant JJ cord-252725-e3pazjdi 103 26 defense defense NN cord-252725-e3pazjdi 103 27 against against IN cord-252725-e3pazjdi 103 28 free free JJ cord-252725-e3pazjdi 103 29 radicals radical NNS cord-252725-e3pazjdi 103 30 , , , cord-252725-e3pazjdi 103 31 which which WDT cord-252725-e3pazjdi 103 32 reinforces reinforce VBZ cord-252725-e3pazjdi 103 33 body body NN cord-252725-e3pazjdi 103 34 immunity immunity NN cord-252725-e3pazjdi 103 35 [ [ -LRB- cord-252725-e3pazjdi 103 36 73 73 CD cord-252725-e3pazjdi 103 37 ] ] -RRB- cord-252725-e3pazjdi 103 38 . . . cord-252725-e3pazjdi 104 1 Kaempferol Kaempferol NNP cord-252725-e3pazjdi 104 2 with with IN cord-252725-e3pazjdi 104 3 its -PRON- PRP$ cord-252725-e3pazjdi 104 4 strong strong JJ cord-252725-e3pazjdi 104 5 antiinflammatory antiinflammatory JJ cord-252725-e3pazjdi 104 6 , , , cord-252725-e3pazjdi 104 7 anti anti JJ cord-252725-e3pazjdi 104 8 - - JJ cord-252725-e3pazjdi 104 9 oxidant oxidant JJ cord-252725-e3pazjdi 104 10 properties property NNS cord-252725-e3pazjdi 104 11 decreased decrease VBD cord-252725-e3pazjdi 104 12 lipopolysaccharide lipopolysaccharide NN cord-252725-e3pazjdi 104 13 ( ( -LRB- cord-252725-e3pazjdi 104 14 LPS)-induced LPS)-induced NNP cord-252725-e3pazjdi 104 15 TNF TNF NNP cord-252725-e3pazjdi 104 16 - - HYPH cord-252725-e3pazjdi 104 17 α α NNP cord-252725-e3pazjdi 104 18 and and CC cord-252725-e3pazjdi 104 19 IL-1β il-1β JJ cord-252725-e3pazjdi 104 20 expression expression NN cord-252725-e3pazjdi 104 21 by by IN cord-252725-e3pazjdi 104 22 increasing increase VBG cord-252725-e3pazjdi 104 23 the the DT cord-252725-e3pazjdi 104 24 number number NN cord-252725-e3pazjdi 104 25 of of IN cord-252725-e3pazjdi 104 26 activated activate VBN cord-252725-e3pazjdi 104 27 macrophages macrophage NNS cord-252725-e3pazjdi 104 28 and and CC cord-252725-e3pazjdi 104 29 inhibited inhibited JJ cord-252725-e3pazjdi 104 30 NF nf NN cord-252725-e3pazjdi 104 31 - - HYPH cord-252725-e3pazjdi 104 32 κB κb CD cord-252725-e3pazjdi 104 33 translocation translocation NN cord-252725-e3pazjdi 104 34 to to IN cord-252725-e3pazjdi 104 35 the the DT cord-252725-e3pazjdi 104 36 nucleus nucleus NN cord-252725-e3pazjdi 104 37 , , , cord-252725-e3pazjdi 104 38 which which WDT cord-252725-e3pazjdi 104 39 blocks block VBZ cord-252725-e3pazjdi 104 40 the the DT cord-252725-e3pazjdi 104 41 inflammatory inflammatory JJ cord-252725-e3pazjdi 104 42 cascade cascade NN cord-252725-e3pazjdi 104 43 pathway pathway NN cord-252725-e3pazjdi 104 44 [ [ -LRB- cord-252725-e3pazjdi 104 45 76 76 CD cord-252725-e3pazjdi 104 46 ] ] -RRB- cord-252725-e3pazjdi 104 47 . . . cord-252725-e3pazjdi 105 1 Kaempferol Kaempferol NNP cord-252725-e3pazjdi 105 2 was be VBD cord-252725-e3pazjdi 105 3 established establish VBN cord-252725-e3pazjdi 105 4 to to TO cord-252725-e3pazjdi 105 5 have have VB cord-252725-e3pazjdi 105 6 a a DT cord-252725-e3pazjdi 105 7 high high JJ cord-252725-e3pazjdi 105 8 antiviral antiviral JJ cord-252725-e3pazjdi 105 9 activity activity NN cord-252725-e3pazjdi 105 10 on on IN cord-252725-e3pazjdi 105 11 both both DT cord-252725-e3pazjdi 105 12 influenza influenza NN cord-252725-e3pazjdi 105 13 viruses virus NNS cord-252725-e3pazjdi 105 14 , , , cord-252725-e3pazjdi 105 15 H1N1 H1N1 NNP cord-252725-e3pazjdi 105 16 and and CC cord-252725-e3pazjdi 105 17 H9N2 H9N2 NNP cord-252725-e3pazjdi 105 18 where where WRB cord-252725-e3pazjdi 105 19 kaempferol kaempferol NNP cord-252725-e3pazjdi 105 20 acts act VBZ cord-252725-e3pazjdi 105 21 on on IN cord-252725-e3pazjdi 105 22 the the DT cord-252725-e3pazjdi 105 23 virus virus NN cord-252725-e3pazjdi 105 24 neuraminidase neuraminidase NN cord-252725-e3pazjdi 105 25 protein protein NN cord-252725-e3pazjdi 105 26 and and CC cord-252725-e3pazjdi 105 27 its -PRON- PRP$ cord-252725-e3pazjdi 105 28 specific specific JJ cord-252725-e3pazjdi 105 29 functional functional JJ cord-252725-e3pazjdi 105 30 groups group NNS cord-252725-e3pazjdi 105 31 [ [ -LRB- cord-252725-e3pazjdi 105 32 77 77 CD cord-252725-e3pazjdi 105 33 ] ] -RRB- cord-252725-e3pazjdi 105 34 . . . cord-252725-e3pazjdi 106 1 Kaempferol Kaempferol NNP cord-252725-e3pazjdi 106 2 is be VBZ cord-252725-e3pazjdi 106 3 considered consider VBN cord-252725-e3pazjdi 106 4 as as IN cord-252725-e3pazjdi 106 5 an an DT cord-252725-e3pazjdi 106 6 effective effective JJ cord-252725-e3pazjdi 106 7 drug drug NN cord-252725-e3pazjdi 106 8 in in IN cord-252725-e3pazjdi 106 9 vitro vitro FW cord-252725-e3pazjdi 106 10 and and CC cord-252725-e3pazjdi 106 11 in in IN cord-252725-e3pazjdi 106 12 vivo vivo NN cord-252725-e3pazjdi 106 13 for for IN cord-252725-e3pazjdi 106 14 the the DT cord-252725-e3pazjdi 106 15 potential potential JJ cord-252725-e3pazjdi 106 16 treatment treatment NN cord-252725-e3pazjdi 106 17 of of IN cord-252725-e3pazjdi 106 18 H9N2 H9N2 NNP cord-252725-e3pazjdi 106 19 influenza influenza NN cord-252725-e3pazjdi 106 20 virus virus NN cord-252725-e3pazjdi 106 21 - - HYPH cord-252725-e3pazjdi 106 22 induced induce VBN cord-252725-e3pazjdi 106 23 inflammation inflammation NN cord-252725-e3pazjdi 106 24 and and CC cord-252725-e3pazjdi 106 25 lung lung NN cord-252725-e3pazjdi 106 26 injury injury NN cord-252725-e3pazjdi 106 27 . . . cord-252725-e3pazjdi 107 1 Kaempferol Kaempferol NNP cord-252725-e3pazjdi 107 2 treatment treatment NN cord-252725-e3pazjdi 107 3 attenuated attenuate VBD cord-252725-e3pazjdi 107 4 pulmonary pulmonary JJ cord-252725-e3pazjdi 107 5 edema edema NN cord-252725-e3pazjdi 107 6 , , , cord-252725-e3pazjdi 107 7 pulmonary pulmonary JJ cord-252725-e3pazjdi 107 8 capillary capillary JJ cord-252725-e3pazjdi 107 9 permeability permeability NN cord-252725-e3pazjdi 107 10 , , , cord-252725-e3pazjdi 107 11 myeloperoxidase myeloperoxidase NNP cord-252725-e3pazjdi 107 12 ( ( -LRB- cord-252725-e3pazjdi 107 13 MPO MPO NNP cord-252725-e3pazjdi 107 14 ) ) -RRB- cord-252725-e3pazjdi 107 15 activity activity NN cord-252725-e3pazjdi 107 16 , , , cord-252725-e3pazjdi 107 17 and and CC cord-252725-e3pazjdi 107 18 the the DT cord-252725-e3pazjdi 107 19 numbers number NNS cord-252725-e3pazjdi 107 20 of of IN cord-252725-e3pazjdi 107 21 inflammatory inflammatory JJ cord-252725-e3pazjdi 107 22 cells cell NNS cord-252725-e3pazjdi 107 23 . . . cord-252725-e3pazjdi 108 1 Kaempferol Kaempferol NNP cord-252725-e3pazjdi 108 2 reduced reduce VBD cord-252725-e3pazjdi 108 3 ROS ROS NNP cord-252725-e3pazjdi 108 4 and and CC cord-252725-e3pazjdi 108 5 Malondialdehyde Malondialdehyde NNP cord-252725-e3pazjdi 108 6 ( ( -LRB- cord-252725-e3pazjdi 108 7 MDA MDA NNP cord-252725-e3pazjdi 108 8 ) ) -RRB- cord-252725-e3pazjdi 108 9 . . . cord-252725-e3pazjdi 109 1 In in IN cord-252725-e3pazjdi 109 2 addition addition NN cord-252725-e3pazjdi 109 3 , , , cord-252725-e3pazjdi 109 4 kaempferol kaempferol NNP cord-252725-e3pazjdi 109 5 also also RB cord-252725-e3pazjdi 109 6 reduced reduce VBD cord-252725-e3pazjdi 109 7 of of IN cord-252725-e3pazjdi 109 8 ROS ROS NNP cord-252725-e3pazjdi 109 9 , , , cord-252725-e3pazjdi 109 10 MDA MDA NNP cord-252725-e3pazjdi 109 11 , , , cord-252725-e3pazjdi 109 12 TNF TNF NNP cord-252725-e3pazjdi 109 13 - - HYPH cord-252725-e3pazjdi 109 14 α α NNP cord-252725-e3pazjdi 109 15 , , , cord-252725-e3pazjdi 109 16 IL-1β IL-1β NNP cord-252725-e3pazjdi 109 17 and and CC cord-252725-e3pazjdi 109 18 IL-6 IL-6 NNP cord-252725-e3pazjdi 109 19 production production NN cord-252725-e3pazjdi 109 20 and and CC cord-252725-e3pazjdi 109 21 significantly significantly RB cord-252725-e3pazjdi 109 22 inhibited inhibit VBD cord-252725-e3pazjdi 109 23 the the DT cord-252725-e3pazjdi 109 24 upregulation upregulation NN cord-252725-e3pazjdi 109 25 of of IN cord-252725-e3pazjdi 109 26 tolllike tolllike NN cord-252725-e3pazjdi 109 27 receptor receptor NN cord-252725-e3pazjdi 109 28 4 4 CD cord-252725-e3pazjdi 109 29 ( ( -LRB- cord-252725-e3pazjdi 109 30 TLR4 TLR4 NNP cord-252725-e3pazjdi 109 31 ) ) -RRB- cord-252725-e3pazjdi 109 32 , , , cord-252725-e3pazjdi 109 33 myeloid myeloid JJ cord-252725-e3pazjdi 109 34 differentiation differentiation NN cord-252725-e3pazjdi 109 35 factor factor NN cord-252725-e3pazjdi 109 36 88 88 CD cord-252725-e3pazjdi 109 37 ( ( -LRB- cord-252725-e3pazjdi 109 38 MyD88 MyD88 NNS cord-252725-e3pazjdi 109 39 ) ) -RRB- cord-252725-e3pazjdi 109 40 and and CC cord-252725-e3pazjdi 109 41 phosphorylation phosphorylation NN cord-252725-e3pazjdi 109 42 of of IN cord-252725-e3pazjdi 109 43 NF nf NN cord-252725-e3pazjdi 109 44 - - HYPH cord-252725-e3pazjdi 109 45 κB κB NNP cord-252725-e3pazjdi 109 46 and and CC cord-252725-e3pazjdi 109 47 MAPKs MAPKs NNP cord-252725-e3pazjdi 109 48 pathways pathway NNS cord-252725-e3pazjdi 109 49 [ [ -LRB- cord-252725-e3pazjdi 109 50 78 78 CD cord-252725-e3pazjdi 109 51 ] ] -RRB- cord-252725-e3pazjdi 109 52 . . . cord-252725-e3pazjdi 110 1 Moreover moreover RB cord-252725-e3pazjdi 110 2 , , , cord-252725-e3pazjdi 110 3 kaempferol kaempferol NNP cord-252725-e3pazjdi 110 4 showed show VBD cord-252725-e3pazjdi 110 5 an an DT cord-252725-e3pazjdi 110 6 antiviral antiviral JJ cord-252725-e3pazjdi 110 7 activity activity NN cord-252725-e3pazjdi 110 8 against against IN cord-252725-e3pazjdi 110 9 influenza influenza NN cord-252725-e3pazjdi 110 10 A a DT cord-252725-e3pazjdi 110 11 replication replication NN cord-252725-e3pazjdi 110 12 and and CC cord-252725-e3pazjdi 110 13 its -PRON- PRP$ cord-252725-e3pazjdi 110 14 spread spread NN cord-252725-e3pazjdi 110 15 through through IN cord-252725-e3pazjdi 110 16 modulating modulate VBG cord-252725-e3pazjdi 110 17 cell cell NN cord-252725-e3pazjdi 110 18 - - HYPH cord-252725-e3pazjdi 110 19 autonomous autonomous JJ cord-252725-e3pazjdi 110 20 immunity immunity NN cord-252725-e3pazjdi 110 21 through through IN cord-252725-e3pazjdi 110 22 MAPK MAPK NNP cord-252725-e3pazjdi 110 23 signaling signal VBG cord-252725-e3pazjdi 110 24 pathways pathway NNS cord-252725-e3pazjdi 110 25 [ [ -LRB- cord-252725-e3pazjdi 110 26 19 19 CD cord-252725-e3pazjdi 110 27 ] ] -RRB- cord-252725-e3pazjdi 110 28 . . . cord-252725-e3pazjdi 111 1 Kaempferol Kaempferol NNP cord-252725-e3pazjdi 111 2 derivatives derivative NNS cord-252725-e3pazjdi 111 3 such such JJ cord-252725-e3pazjdi 111 4 as as IN cord-252725-e3pazjdi 111 5 kaempferol kaempferol NNP cord-252725-e3pazjdi 111 6 glycosides glycoside NNS cord-252725-e3pazjdi 111 7 and and CC cord-252725-e3pazjdi 111 8 acylated acylated NNP cord-252725-e3pazjdi 111 9 kaempferol kaempferol NNP cord-252725-e3pazjdi 111 10 glucoside glucoside NN cord-252725-e3pazjdi 111 11 showed show VBD cord-252725-e3pazjdi 111 12 comparable comparable JJ cord-252725-e3pazjdi 111 13 antiviral antiviral JJ cord-252725-e3pazjdi 111 14 activities activity NNS cord-252725-e3pazjdi 111 15 against against IN cord-252725-e3pazjdi 111 16 the the DT cord-252725-e3pazjdi 111 17 3a 3a NNP cord-252725-e3pazjdi 111 18 channel channel NNP cord-252725-e3pazjdi 111 19 protein protein NNP cord-252725-e3pazjdi 111 20 of of IN cord-252725-e3pazjdi 111 21 SARS SARS NNP cord-252725-e3pazjdi 111 22 coronavirus coronavirus NN cord-252725-e3pazjdi 111 23 that that WDT cord-252725-e3pazjdi 111 24 may may MD cord-252725-e3pazjdi 111 25 become become VB cord-252725-e3pazjdi 111 26 expressed express VBN cord-252725-e3pazjdi 111 27 in in IN cord-252725-e3pazjdi 111 28 the the DT cord-252725-e3pazjdi 111 29 infected infected JJ cord-252725-e3pazjdi 111 30 cells cell NNS cord-252725-e3pazjdi 111 31 . . . cord-252725-e3pazjdi 112 1 Therefore therefore RB cord-252725-e3pazjdi 112 2 , , , cord-252725-e3pazjdi 112 3 inhibition inhibition NN cord-252725-e3pazjdi 112 4 of of IN cord-252725-e3pazjdi 112 5 virus virus NN cord-252725-e3pazjdi 112 6 production production NN cord-252725-e3pazjdi 112 7 and and CC cord-252725-e3pazjdi 112 8 allowing allow VBG cord-252725-e3pazjdi 112 9 the the DT cord-252725-e3pazjdi 112 10 infected infected JJ cord-252725-e3pazjdi 112 11 body body NN cord-252725-e3pazjdi 112 12 to to TO cord-252725-e3pazjdi 112 13 build build VB cord-252725-e3pazjdi 112 14 up up RP cord-252725-e3pazjdi 112 15 or or CC cord-252725-e3pazjdi 112 16 strengthening strengthen VBG cord-252725-e3pazjdi 112 17 its -PRON- PRP$ cord-252725-e3pazjdi 112 18 own own JJ cord-252725-e3pazjdi 112 19 immune immune JJ cord-252725-e3pazjdi 112 20 system system NN cord-252725-e3pazjdi 112 21 [ [ -LRB- cord-252725-e3pazjdi 112 22 79 79 CD cord-252725-e3pazjdi 112 23 ] ] -RRB- cord-252725-e3pazjdi 112 24 . . . cord-252725-e3pazjdi 113 1 Likewise likewise RB cord-252725-e3pazjdi 113 2 , , , cord-252725-e3pazjdi 113 3 a a DT cord-252725-e3pazjdi 113 4 docking docking NN cord-252725-e3pazjdi 113 5 study study NN cord-252725-e3pazjdi 113 6 indicated indicate VBD cord-252725-e3pazjdi 113 7 that that IN cord-252725-e3pazjdi 113 8 kaempferol kaempferol NNP cord-252725-e3pazjdi 113 9 derivatives derivative NNS cord-252725-e3pazjdi 113 10 effectively effectively RB cord-252725-e3pazjdi 113 11 reduced reduce VBD cord-252725-e3pazjdi 113 12 the the DT cord-252725-e3pazjdi 113 13 proteolytic proteolytic JJ cord-252725-e3pazjdi 113 14 activity activity NN cord-252725-e3pazjdi 113 15 of of IN cord-252725-e3pazjdi 113 16 Middle Middle NNP cord-252725-e3pazjdi 113 17 East East NNP cord-252725-e3pazjdi 113 18 respiratory respiratory JJ cord-252725-e3pazjdi 113 19 syndromecoronavirus syndromecoronavirus NN cord-252725-e3pazjdi 113 20 ( ( -LRB- cord-252725-e3pazjdi 113 21 MERS MERS NNP cord-252725-e3pazjdi 113 22 - - HYPH cord-252725-e3pazjdi 113 23 CoV CoV NNP cord-252725-e3pazjdi 113 24 ) ) -RRB- cord-252725-e3pazjdi 113 25 by by IN cord-252725-e3pazjdi 113 26 its -PRON- PRP$ cord-252725-e3pazjdi 113 27 ability ability NN cord-252725-e3pazjdi 113 28 to to TO cord-252725-e3pazjdi 113 29 occupy occupy VB cord-252725-e3pazjdi 113 30 the the DT cord-252725-e3pazjdi 113 31 S1 S1 NNP cord-252725-e3pazjdi 113 32 and and CC cord-252725-e3pazjdi 113 33 S2 s2 NN cord-252725-e3pazjdi 113 34 sites site NNS cord-252725-e3pazjdi 113 35 of of IN cord-252725-e3pazjdi 113 36 MERS MERS NNP cord-252725-e3pazjdi 113 37 - - HYPH cord-252725-e3pazjdi 113 38 CoV CoV NNP cord-252725-e3pazjdi 113 39 3CLpro 3clpro CD cord-252725-e3pazjdi 113 40 [ [ -LRB- cord-252725-e3pazjdi 113 41 9 9 CD cord-252725-e3pazjdi 113 42 ] ] -RRB- cord-252725-e3pazjdi 113 43 . . . cord-252725-e3pazjdi 114 1 Therefore therefore RB cord-252725-e3pazjdi 114 2 , , , cord-252725-e3pazjdi 114 3 Kaempferol Kaempferol NNP cord-252725-e3pazjdi 114 4 and and CC cord-252725-e3pazjdi 114 5 its -PRON- PRP$ cord-252725-e3pazjdi 114 6 derivatives derivative NNS cord-252725-e3pazjdi 114 7 might may MD cord-252725-e3pazjdi 114 8 be be VB cord-252725-e3pazjdi 114 9 selected select VBN cord-252725-e3pazjdi 114 10 as as IN cord-252725-e3pazjdi 114 11 alternatives alternative NNS cord-252725-e3pazjdi 114 12 to to TO cord-252725-e3pazjdi 114 13 fight fight VB cord-252725-e3pazjdi 114 14 COVID-19 covid-19 JJ cord-252725-e3pazjdi 114 15 infection infection NN cord-252725-e3pazjdi 114 16 possibly possibly RB cord-252725-e3pazjdi 114 17 through through IN cord-252725-e3pazjdi 114 18 targeting target VBG cord-252725-e3pazjdi 114 19 coronavirus coronavirus NN cord-252725-e3pazjdi 114 20 proteases protease NNS cord-252725-e3pazjdi 114 21 . . . cord-252725-e3pazjdi 115 1 Apigenin Apigenin NNP cord-252725-e3pazjdi 115 2 ( ( -LRB- cord-252725-e3pazjdi 115 3 4′,5,7-trihydroxyflavone 4′,5,7-trihydroxyflavone CD cord-252725-e3pazjdi 115 4 ) ) -RRB- cord-252725-e3pazjdi 115 5 ( ( -LRB- cord-252725-e3pazjdi 115 6 Fig Fig NNP cord-252725-e3pazjdi 115 7 . . . cord-252725-e3pazjdi 115 8 6 6 CD cord-252725-e3pazjdi 115 9 ) ) -RRB- cord-252725-e3pazjdi 115 10 , , , cord-252725-e3pazjdi 115 11 a a DT cord-252725-e3pazjdi 115 12 naturally naturally RB cord-252725-e3pazjdi 115 13 occurring occur VBG cord-252725-e3pazjdi 115 14 flavone flavone NN cord-252725-e3pazjdi 115 15 compound compound NNP cord-252725-e3pazjdi 115 16 is be VBZ cord-252725-e3pazjdi 115 17 found find VBN cord-252725-e3pazjdi 115 18 in in IN cord-252725-e3pazjdi 115 19 large large JJ cord-252725-e3pazjdi 115 20 quantities quantity NNS cord-252725-e3pazjdi 115 21 in in IN cord-252725-e3pazjdi 115 22 fruits fruit NNS cord-252725-e3pazjdi 115 23 , , , cord-252725-e3pazjdi 115 24 vegetables vegetable NNS cord-252725-e3pazjdi 115 25 , , , cord-252725-e3pazjdi 115 26 beverages beverage NNS cord-252725-e3pazjdi 115 27 and and CC cord-252725-e3pazjdi 115 28 medicinal medicinal JJ cord-252725-e3pazjdi 115 29 herbs herb NNS cord-252725-e3pazjdi 115 30 such such JJ cord-252725-e3pazjdi 115 31 as as IN cord-252725-e3pazjdi 115 32 parsley parsley NN cord-252725-e3pazjdi 115 33 , , , cord-252725-e3pazjdi 115 34 grapes grape NNS cord-252725-e3pazjdi 115 35 , , , cord-252725-e3pazjdi 115 36 apples apple NNS cord-252725-e3pazjdi 115 37 , , , cord-252725-e3pazjdi 115 38 celery celery NN cord-252725-e3pazjdi 115 39 , , , cord-252725-e3pazjdi 115 40 celeriac celeriac NN cord-252725-e3pazjdi 115 41 , , , cord-252725-e3pazjdi 115 42 thyme thyme NNS cord-252725-e3pazjdi 115 43 , , , cord-252725-e3pazjdi 115 44 oregano oregano NN cord-252725-e3pazjdi 115 45 , , , cord-252725-e3pazjdi 115 46 basil basil NN cord-252725-e3pazjdi 115 47 , , , cord-252725-e3pazjdi 115 48 chamomile chamomile NN cord-252725-e3pazjdi 115 49 tea tea NN cord-252725-e3pazjdi 115 50 , , , cord-252725-e3pazjdi 115 51 beer beer NN cord-252725-e3pazjdi 115 52 , , , cord-252725-e3pazjdi 115 53 and and CC cord-252725-e3pazjdi 115 54 wine wine NN cord-252725-e3pazjdi 115 55 [ [ -LRB- cord-252725-e3pazjdi 115 56 80 80 CD cord-252725-e3pazjdi 115 57 ] ] -RRB- cord-252725-e3pazjdi 115 58 . . . cord-252725-e3pazjdi 116 1 Apigenin Apigenin NNP cord-252725-e3pazjdi 116 2 encompasses encompass VBZ cord-252725-e3pazjdi 116 3 a a DT cord-252725-e3pazjdi 116 4 number number NN cord-252725-e3pazjdi 116 5 of of IN cord-252725-e3pazjdi 116 6 biological biological JJ cord-252725-e3pazjdi 116 7 functions function NNS cord-252725-e3pazjdi 116 8 , , , cord-252725-e3pazjdi 116 9 for for IN cord-252725-e3pazjdi 116 10 instance instance NN cord-252725-e3pazjdi 116 11 strong strong JJ cord-252725-e3pazjdi 116 12 anti anti JJ cord-252725-e3pazjdi 116 13 - - JJ cord-252725-e3pazjdi 116 14 inflammatory inflammatory JJ cord-252725-e3pazjdi 116 15 , , , cord-252725-e3pazjdi 116 16 antioxidant antioxidant NN cord-252725-e3pazjdi 116 17 , , , cord-252725-e3pazjdi 116 18 antibacterial antibacterial JJ cord-252725-e3pazjdi 116 19 and and CC cord-252725-e3pazjdi 116 20 antiviral antiviral JJ cord-252725-e3pazjdi 116 21 activities activity NNS cord-252725-e3pazjdi 116 22 and and CC cord-252725-e3pazjdi 116 23 blood blood NN cord-252725-e3pazjdi 116 24 pressure pressure NN cord-252725-e3pazjdi 116 25 reduction reduction NN cord-252725-e3pazjdi 116 26 agent agent NN cord-252725-e3pazjdi 116 27 . . . cord-252725-e3pazjdi 117 1 Several several JJ cord-252725-e3pazjdi 117 2 in in IN cord-252725-e3pazjdi 117 3 vivo vivo NN cord-252725-e3pazjdi 117 4 and and CC cord-252725-e3pazjdi 117 5 in in IN cord-252725-e3pazjdi 117 6 vitro vitro FW cord-252725-e3pazjdi 117 7 studies study NNS cord-252725-e3pazjdi 117 8 and and CC cord-252725-e3pazjdi 117 9 clinical clinical JJ cord-252725-e3pazjdi 117 10 trials trial NNS cord-252725-e3pazjdi 117 11 suggested suggest VBD cord-252725-e3pazjdi 117 12 that that IN cord-252725-e3pazjdi 117 13 apigenin apigenin NNP cord-252725-e3pazjdi 117 14 is be VBZ cord-252725-e3pazjdi 117 15 a a DT cord-252725-e3pazjdi 117 16 potent potent JJ cord-252725-e3pazjdi 117 17 therapeutic therapeutic JJ cord-252725-e3pazjdi 117 18 agent agent NN cord-252725-e3pazjdi 117 19 to to TO cord-252725-e3pazjdi 117 20 overcome overcome VB cord-252725-e3pazjdi 117 21 diseases disease NNS cord-252725-e3pazjdi 117 22 such such JJ cord-252725-e3pazjdi 117 23 as as IN cord-252725-e3pazjdi 117 24 rheumatoid rheumatoid JJ cord-252725-e3pazjdi 117 25 arthritis arthritis NN cord-252725-e3pazjdi 117 26 , , , cord-252725-e3pazjdi 117 27 autoimmune autoimmune JJ cord-252725-e3pazjdi 117 28 disorders disorder NNS cord-252725-e3pazjdi 117 29 , , , cord-252725-e3pazjdi 117 30 Parkinson Parkinson NNP cord-252725-e3pazjdi 117 31 's 's POS cord-252725-e3pazjdi 117 32 disease disease NN cord-252725-e3pazjdi 117 33 , , , cord-252725-e3pazjdi 117 34 Alzheimer Alzheimer NNP cord-252725-e3pazjdi 117 35 's 's POS cord-252725-e3pazjdi 117 36 disease disease NN cord-252725-e3pazjdi 117 37 , , , cord-252725-e3pazjdi 117 38 and and CC cord-252725-e3pazjdi 117 39 a a DT cord-252725-e3pazjdi 117 40 various various JJ cord-252725-e3pazjdi 117 41 type type NN cord-252725-e3pazjdi 117 42 of of IN cord-252725-e3pazjdi 117 43 cancers cancer NNS cord-252725-e3pazjdi 117 44 [ [ -LRB- cord-252725-e3pazjdi 117 45 81 81 CD cord-252725-e3pazjdi 117 46 , , , cord-252725-e3pazjdi 117 47 82 82 CD cord-252725-e3pazjdi 117 48 ] ] -RRB- cord-252725-e3pazjdi 117 49 . . . cord-252725-e3pazjdi 118 1 In in IN cord-252725-e3pazjdi 118 2 fact fact NN cord-252725-e3pazjdi 118 3 , , , cord-252725-e3pazjdi 118 4 apigenin apigenin NNP cord-252725-e3pazjdi 118 5 stimulates stimulate VBZ cord-252725-e3pazjdi 118 6 different different JJ cord-252725-e3pazjdi 118 7 anti anti JJ cord-252725-e3pazjdi 118 8 - - JJ cord-252725-e3pazjdi 118 9 inflammatory inflammatory JJ cord-252725-e3pazjdi 118 10 pathways pathway NNS cord-252725-e3pazjdi 118 11 , , , cord-252725-e3pazjdi 118 12 including include VBG cord-252725-e3pazjdi 118 13 p38/ p38/ XX cord-252725-e3pazjdi 118 14 MAPK MAPK NNP cord-252725-e3pazjdi 118 15 and and CC cord-252725-e3pazjdi 118 16 PI3K PI3K NNP cord-252725-e3pazjdi 118 17 / / SYM cord-252725-e3pazjdi 118 18 Akt Akt NNP cord-252725-e3pazjdi 118 19 , , , cord-252725-e3pazjdi 118 20 prevents prevent VBZ cord-252725-e3pazjdi 118 21 the the DT cord-252725-e3pazjdi 118 22 nuclear nuclear JJ cord-252725-e3pazjdi 118 23 translocation translocation NN cord-252725-e3pazjdi 118 24 of of IN cord-252725-e3pazjdi 118 25 the the DT cord-252725-e3pazjdi 118 26 NF nf NN cord-252725-e3pazjdi 118 27 - - HYPH cord-252725-e3pazjdi 118 28 κB κB NNP cord-252725-e3pazjdi 118 29 , , , cord-252725-e3pazjdi 118 30 reduces reduce VBZ cord-252725-e3pazjdi 118 31 COX-2 cox-2 JJ cord-252725-e3pazjdi 118 32 activity activity NN cord-252725-e3pazjdi 118 33 and and CC cord-252725-e3pazjdi 118 34 strongly strongly RB cord-252725-e3pazjdi 118 35 decreases decrease VBZ cord-252725-e3pazjdi 118 36 levels level NNS cord-252725-e3pazjdi 118 37 of of IN cord-252725-e3pazjdi 118 38 IL-6 IL-6 NNP cord-252725-e3pazjdi 118 39 , , , cord-252725-e3pazjdi 118 40 TNF TNF NNP cord-252725-e3pazjdi 118 41 - - HYPH cord-252725-e3pazjdi 118 42 α α NNP cord-252725-e3pazjdi 118 43 and and CC cord-252725-e3pazjdi 118 44 IFN IFN NNP cord-252725-e3pazjdi 118 45 - - HYPH cord-252725-e3pazjdi 118 46 γ γ NN cord-252725-e3pazjdi 118 47 levels level NNS cord-252725-e3pazjdi 118 48 [ [ -LRB- cord-252725-e3pazjdi 118 49 80 80 CD cord-252725-e3pazjdi 118 50 ] ] -RRB- cord-252725-e3pazjdi 118 51 . . . cord-252725-e3pazjdi 119 1 Moreover moreover RB cord-252725-e3pazjdi 119 2 , , , cord-252725-e3pazjdi 119 3 the the DT cord-252725-e3pazjdi 119 4 influenza influenza NN cord-252725-e3pazjdi 119 5 virus virus NN cord-252725-e3pazjdi 119 6 H3N2 H3N2 NNP cord-252725-e3pazjdi 119 7 was be VBD cord-252725-e3pazjdi 119 8 found find VBN cord-252725-e3pazjdi 119 9 to to TO cord-252725-e3pazjdi 119 10 be be VB cord-252725-e3pazjdi 119 11 inhibited inhibit VBN cord-252725-e3pazjdi 119 12 by by IN cord-252725-e3pazjdi 119 13 Elsholtzia Elsholtzia NNP cord-252725-e3pazjdi 119 14 rugulosa rugulosa JJ cord-252725-e3pazjdi 119 15 ( ( -LRB- cord-252725-e3pazjdi 119 16 Lamiaceae Lamiaceae NNP cord-252725-e3pazjdi 119 17 ) ) -RRB- cord-252725-e3pazjdi 120 1 , , , cord-252725-e3pazjdi 120 2 a a DT cord-252725-e3pazjdi 120 3 common common JJ cord-252725-e3pazjdi 120 4 Chinese chinese JJ cord-252725-e3pazjdi 120 5 herb herb NN cord-252725-e3pazjdi 120 6 contains contain VBZ cord-252725-e3pazjdi 120 7 apigenin apigenin NN cord-252725-e3pazjdi 120 8 and and CC cord-252725-e3pazjdi 120 9 luteolin luteolin NN cord-252725-e3pazjdi 120 10 among among IN cord-252725-e3pazjdi 120 11 other other JJ cord-252725-e3pazjdi 120 12 flavonoids flavonoid NNS cord-252725-e3pazjdi 120 13 [ [ -LRB- cord-252725-e3pazjdi 120 14 83 83 CD cord-252725-e3pazjdi 120 15 ] ] -RRB- cord-252725-e3pazjdi 120 16 . . . cord-252725-e3pazjdi 121 1 Furthermore furthermore RB cord-252725-e3pazjdi 121 2 , , , cord-252725-e3pazjdi 121 3 apigenin apigenin NNP cord-252725-e3pazjdi 121 4 has have VBZ cord-252725-e3pazjdi 121 5 shown show VBN cord-252725-e3pazjdi 121 6 several several JJ cord-252725-e3pazjdi 121 7 antiviral antiviral JJ cord-252725-e3pazjdi 121 8 activities activity NNS cord-252725-e3pazjdi 121 9 against against IN cord-252725-e3pazjdi 121 10 different different JJ cord-252725-e3pazjdi 121 11 viruses virus NNS cord-252725-e3pazjdi 121 12 such such JJ cord-252725-e3pazjdi 121 13 as as IN cord-252725-e3pazjdi 121 14 adenoviruses adenovirus NNS cord-252725-e3pazjdi 121 15 ( ( -LRB- cord-252725-e3pazjdi 121 16 ADV ADV NNP cord-252725-e3pazjdi 121 17 ) ) -RRB- cord-252725-e3pazjdi 121 18 and and CC cord-252725-e3pazjdi 121 19 hepatitis hepatitis NNP cord-252725-e3pazjdi 121 20 B B NNP cord-252725-e3pazjdi 121 21 virus virus NN cord-252725-e3pazjdi 121 22 in in IN cord-252725-e3pazjdi 121 23 vitro vitro FW cord-252725-e3pazjdi 121 24 , , , cord-252725-e3pazjdi 121 25 African african JJ cord-252725-e3pazjdi 121 26 swine swine NN cord-252725-e3pazjdi 121 27 fever fever NN cord-252725-e3pazjdi 121 28 virus virus NN cord-252725-e3pazjdi 121 29 ( ( -LRB- cord-252725-e3pazjdi 121 30 ASFV ASFV NNP cord-252725-e3pazjdi 121 31 ) ) -RRB- cord-252725-e3pazjdi 121 32 , , , cord-252725-e3pazjdi 121 33 by by IN cord-252725-e3pazjdi 121 34 suppressing suppress VBG cord-252725-e3pazjdi 121 35 the the DT cord-252725-e3pazjdi 121 36 viral viral JJ cord-252725-e3pazjdi 121 37 protein protein NN cord-252725-e3pazjdi 121 38 synthesis synthesis NN cord-252725-e3pazjdi 121 39 and and CC cord-252725-e3pazjdi 121 40 reducing reduce VBG cord-252725-e3pazjdi 121 41 the the DT cord-252725-e3pazjdi 121 42 ASFV ASFV NNP cord-252725-e3pazjdi 121 43 yield yield NN cord-252725-e3pazjdi 121 44 by by IN cord-252725-e3pazjdi 121 45 3 3 CD cord-252725-e3pazjdi 121 46 log log NN cord-252725-e3pazjdi 121 47 , , , cord-252725-e3pazjdi 121 48 inhibition inhibition NN cord-252725-e3pazjdi 121 49 of of IN cord-252725-e3pazjdi 121 50 viral viral JJ cord-252725-e3pazjdi 121 51 protein protein NN cord-252725-e3pazjdi 121 52 synthesis synthesis NN cord-252725-e3pazjdi 121 53 through through IN cord-252725-e3pazjdi 121 54 suppressing suppress VBG cord-252725-e3pazjdi 121 55 viral viral JJ cord-252725-e3pazjdi 121 56 IRES ires JJ cord-252725-e3pazjdi 121 57 activity activity NN cord-252725-e3pazjdi 121 58 of of IN cord-252725-e3pazjdi 121 59 picornaviruses picornavirus NNS cord-252725-e3pazjdi 121 60 and and CC cord-252725-e3pazjdi 121 61 disrupting disrupt VBG cord-252725-e3pazjdi 121 62 viral viral JJ cord-252725-e3pazjdi 121 63 RNA rna NN cord-252725-e3pazjdi 121 64 of of IN cord-252725-e3pazjdi 121 65 enterovirus-71 enterovirus-71 NN cord-252725-e3pazjdi 122 1 ( ( -LRB- cord-252725-e3pazjdi 122 2 EV71 EV71 NNP cord-252725-e3pazjdi 122 3 ) ) -RRB- cord-252725-e3pazjdi 122 4 [ [ -LRB- cord-252725-e3pazjdi 122 5 84 84 CD cord-252725-e3pazjdi 122 6 ] ] -RRB- cord-252725-e3pazjdi 122 7 . . . cord-252725-e3pazjdi 123 1 An an DT cord-252725-e3pazjdi 123 2 anti anti JJ cord-252725-e3pazjdi 123 3 - - JJ cord-252725-e3pazjdi 123 4 inflammatory inflammatory JJ cord-252725-e3pazjdi 123 5 effect effect NN cord-252725-e3pazjdi 123 6 of of IN cord-252725-e3pazjdi 123 7 apigenin-7-glycoside apigenin-7-glycoside NN cord-252725-e3pazjdi 123 8 in in IN cord-252725-e3pazjdi 123 9 LPSstimulated lpsstimulated JJ cord-252725-e3pazjdi 123 10 acute acute JJ cord-252725-e3pazjdi 123 11 lung lung NN cord-252725-e3pazjdi 123 12 injury injury NN cord-252725-e3pazjdi 123 13 via via IN cord-252725-e3pazjdi 123 14 downregulation downregulation NN cord-252725-e3pazjdi 123 15 of of IN cord-252725-e3pazjdi 123 16 oxidative oxidative JJ cord-252725-e3pazjdi 123 17 enzyme enzyme NN cord-252725-e3pazjdi 123 18 expression expression NN cord-252725-e3pazjdi 123 19 and and CC cord-252725-e3pazjdi 123 20 protein protein NN cord-252725-e3pazjdi 123 21 activation activation NN cord-252725-e3pazjdi 123 22 through through IN cord-252725-e3pazjdi 123 23 inhibition inhibition NN cord-252725-e3pazjdi 123 24 of of IN cord-252725-e3pazjdi 123 25 MAPK MAPK NNP cord-252725-e3pazjdi 123 26 phosphorylation phosphorylation NN cord-252725-e3pazjdi 123 27 and and CC cord-252725-e3pazjdi 123 28 NF nf NN cord-252725-e3pazjdi 123 29 - - HYPH cord-252725-e3pazjdi 123 30 κB κb CD cord-252725-e3pazjdi 123 31 pathways pathway NNS cord-252725-e3pazjdi 123 32 was be VBD cord-252725-e3pazjdi 123 33 also also RB cord-252725-e3pazjdi 123 34 reported report VBN cord-252725-e3pazjdi 123 35 which which WDT cord-252725-e3pazjdi 123 36 may may MD cord-252725-e3pazjdi 123 37 be be VB cord-252725-e3pazjdi 123 38 a a DT cord-252725-e3pazjdi 123 39 promising promising JJ cord-252725-e3pazjdi 123 40 therapeutic therapeutic JJ cord-252725-e3pazjdi 123 41 candidate candidate NN cord-252725-e3pazjdi 123 42 for for IN cord-252725-e3pazjdi 123 43 various various JJ cord-252725-e3pazjdi 123 44 lung lung NN cord-252725-e3pazjdi 123 45 inflammatory inflammatory JJ cord-252725-e3pazjdi 123 46 disorders disorder NNS cord-252725-e3pazjdi 123 47 , , , cord-252725-e3pazjdi 123 48 such such JJ cord-252725-e3pazjdi 123 49 as as IN cord-252725-e3pazjdi 123 50 lung lung NN cord-252725-e3pazjdi 123 51 disease disease NN cord-252725-e3pazjdi 123 52 and and CC cord-252725-e3pazjdi 123 53 obstructive obstructive JJ cord-252725-e3pazjdi 123 54 pulmonary pulmonary JJ cord-252725-e3pazjdi 123 55 [ [ -LRB- cord-252725-e3pazjdi 123 56 85 85 CD cord-252725-e3pazjdi 123 57 ] ] -RRB- cord-252725-e3pazjdi 123 58 . . . cord-252725-e3pazjdi 124 1 Apigenin Apigenin NNS cord-252725-e3pazjdi 124 2 among among IN cord-252725-e3pazjdi 124 3 other other JJ cord-252725-e3pazjdi 124 4 flavonoids flavonoid NNS cord-252725-e3pazjdi 124 5 has have VBZ cord-252725-e3pazjdi 124 6 been be VBN cord-252725-e3pazjdi 124 7 reported report VBN cord-252725-e3pazjdi 124 8 to to TO cord-252725-e3pazjdi 124 9 inhibit inhibit VB cord-252725-e3pazjdi 124 10 the the DT cord-252725-e3pazjdi 124 11 proteolytic proteolytic JJ cord-252725-e3pazjdi 124 12 activity activity NN cord-252725-e3pazjdi 124 13 of of IN cord-252725-e3pazjdi 124 14 SARS SARS NNP cord-252725-e3pazjdi 124 15 - - HYPH cord-252725-e3pazjdi 124 16 CoV CoV NNP cord-252725-e3pazjdi 124 17 3CLpro 3clpro CD cord-252725-e3pazjdi 124 18 . . . cord-252725-e3pazjdi 125 1 The the DT cord-252725-e3pazjdi 125 2 antiviral antiviral JJ cord-252725-e3pazjdi 125 3 effect effect NN cord-252725-e3pazjdi 125 4 is be VBZ cord-252725-e3pazjdi 125 5 presumed presume VBN cord-252725-e3pazjdi 125 6 to to TO cord-252725-e3pazjdi 125 7 be be VB cord-252725-e3pazjdi 125 8 directly directly RB cord-252725-e3pazjdi 125 9 linked link VBN cord-252725-e3pazjdi 125 10 to to TO cord-252725-e3pazjdi 125 11 suppress suppress VB cord-252725-e3pazjdi 125 12 the the DT cord-252725-e3pazjdi 125 13 activity activity NN cord-252725-e3pazjdi 125 14 of of IN cord-252725-e3pazjdi 125 15 SARS SARS NNP cord-252725-e3pazjdi 125 16 - - HYPH cord-252725-e3pazjdi 125 17 CoV CoV NNP cord-252725-e3pazjdi 125 18 3CLpro 3clpro CD cord-252725-e3pazjdi 125 19 [ [ -LRB- cord-252725-e3pazjdi 125 20 40 40 CD cord-252725-e3pazjdi 125 21 ] ] -RRB- cord-252725-e3pazjdi 125 22 and and CC cord-252725-e3pazjdi 125 23 thus thus RB cord-252725-e3pazjdi 125 24 apigenin apigenin NNP cord-252725-e3pazjdi 125 25 intake intake NN cord-252725-e3pazjdi 125 26 , , , cord-252725-e3pazjdi 125 27 through through IN cord-252725-e3pazjdi 125 28 either either CC cord-252725-e3pazjdi 125 29 a a DT cord-252725-e3pazjdi 125 30 regular regular JJ cord-252725-e3pazjdi 125 31 diet diet NN cord-252725-e3pazjdi 125 32 or or CC cord-252725-e3pazjdi 125 33 supplements supplement NNS cord-252725-e3pazjdi 125 34 , , , cord-252725-e3pazjdi 125 35 may may MD cord-252725-e3pazjdi 125 36 be be VB cord-252725-e3pazjdi 125 37 beneficial beneficial JJ cord-252725-e3pazjdi 125 38 for for IN cord-252725-e3pazjdi 125 39 chronically chronically RB cord-252725-e3pazjdi 125 40 infected infect VBN cord-252725-e3pazjdi 125 41 disease disease NN cord-252725-e3pazjdi 125 42 such such JJ cord-252725-e3pazjdi 125 43 as as IN cord-252725-e3pazjdi 125 44 COVID19 COVID19 NNP cord-252725-e3pazjdi 125 45 . . . cord-252725-e3pazjdi 126 1 Luteolin Luteolin NNP cord-252725-e3pazjdi 126 2 , , , cord-252725-e3pazjdi 126 3 3′,4′,5,7-tetrahydroxyflavone 3′,4′,5,7-tetrahydroxyflavone NNP cord-252725-e3pazjdi 126 4 ( ( -LRB- cord-252725-e3pazjdi 126 5 Fig Fig NNP cord-252725-e3pazjdi 126 6 . . NNP cord-252725-e3pazjdi 126 7 7 7 CD cord-252725-e3pazjdi 126 8 ) ) -RRB- cord-252725-e3pazjdi 126 9 which which WDT cord-252725-e3pazjdi 126 10 belongs belong VBZ cord-252725-e3pazjdi 126 11 to to IN cord-252725-e3pazjdi 126 12 the the DT cord-252725-e3pazjdi 126 13 flavone flavone NNP cord-252725-e3pazjdi 126 14 group group NN cord-252725-e3pazjdi 126 15 of of IN cord-252725-e3pazjdi 126 16 flavonoids flavonoid NNS cord-252725-e3pazjdi 126 17 , , , cord-252725-e3pazjdi 126 18 is be VBZ cord-252725-e3pazjdi 126 19 a a DT cord-252725-e3pazjdi 126 20 natural natural JJ cord-252725-e3pazjdi 126 21 yellow yellow JJ cord-252725-e3pazjdi 126 22 dye dye NN cord-252725-e3pazjdi 126 23 found find VBN cord-252725-e3pazjdi 126 24 widely widely RB cord-252725-e3pazjdi 126 25 in in IN cord-252725-e3pazjdi 126 26 the the DT cord-252725-e3pazjdi 126 27 plant plant NN cord-252725-e3pazjdi 126 28 kingdom kingdom NN cord-252725-e3pazjdi 126 29 including include VBG cord-252725-e3pazjdi 126 30 fruits fruit NNS cord-252725-e3pazjdi 126 31 , , , cord-252725-e3pazjdi 126 32 vegetables vegetable NNS cord-252725-e3pazjdi 126 33 , , , cord-252725-e3pazjdi 126 34 and and CC cord-252725-e3pazjdi 126 35 medicinal medicinal JJ cord-252725-e3pazjdi 126 36 herbs herb NNS cord-252725-e3pazjdi 126 37 such such JJ cord-252725-e3pazjdi 126 38 as as IN cord-252725-e3pazjdi 126 39 broccoli broccoli NN cord-252725-e3pazjdi 126 40 , , , cord-252725-e3pazjdi 126 41 pepper pepper NN cord-252725-e3pazjdi 126 42 , , , cord-252725-e3pazjdi 126 43 thyme thyme NNS cord-252725-e3pazjdi 126 44 , , , cord-252725-e3pazjdi 126 45 and and CC cord-252725-e3pazjdi 126 46 celery celery NN cord-252725-e3pazjdi 126 47 , , , cord-252725-e3pazjdi 126 48 carrots carrot NNS cord-252725-e3pazjdi 126 49 , , , cord-252725-e3pazjdi 126 50 olive olive NN cord-252725-e3pazjdi 126 51 oil oil NN cord-252725-e3pazjdi 126 52 , , , cord-252725-e3pazjdi 126 53 peppermint peppermint NN cord-252725-e3pazjdi 126 54 , , , cord-252725-e3pazjdi 126 55 thyme thyme NNS cord-252725-e3pazjdi 126 56 , , , cord-252725-e3pazjdi 126 57 rosemary rosemary NN cord-252725-e3pazjdi 126 58 , , , cord-252725-e3pazjdi 126 59 oregano oregano NN cord-252725-e3pazjdi 126 60 , , , cord-252725-e3pazjdi 126 61 rosemary rosemary NN cord-252725-e3pazjdi 126 62 , , , cord-252725-e3pazjdi 126 63 navel navel NN cord-252725-e3pazjdi 126 64 oranges orange NNS cord-252725-e3pazjdi 126 65 , , , cord-252725-e3pazjdi 126 66 dandelion dandelion NN cord-252725-e3pazjdi 126 67 , , , cord-252725-e3pazjdi 126 68 perilla perilla NN cord-252725-e3pazjdi 126 69 leaf leaf NN cord-252725-e3pazjdi 126 70 , , , cord-252725-e3pazjdi 126 71 chamomile chamomile NN cord-252725-e3pazjdi 126 72 tea tea NN cord-252725-e3pazjdi 126 73 [ [ -LRB- cord-252725-e3pazjdi 126 74 86 86 CD cord-252725-e3pazjdi 126 75 ] ] -RRB- cord-252725-e3pazjdi 126 76 . . . cord-252725-e3pazjdi 127 1 Luteolin Luteolin NNP cord-252725-e3pazjdi 127 2 , , , cord-252725-e3pazjdi 127 3 like like IN cord-252725-e3pazjdi 127 4 some some DT cord-252725-e3pazjdi 127 5 other other JJ cord-252725-e3pazjdi 127 6 flavonoid flavonoid NN cord-252725-e3pazjdi 127 7 compounds compound NNS cord-252725-e3pazjdi 127 8 exerts exert VBZ cord-252725-e3pazjdi 127 9 several several JJ cord-252725-e3pazjdi 127 10 pharmacological pharmacological JJ cord-252725-e3pazjdi 127 11 activities activity NNS cord-252725-e3pazjdi 127 12 , , , cord-252725-e3pazjdi 127 13 immuno immuno JJ cord-252725-e3pazjdi 127 14 - - HYPH cord-252725-e3pazjdi 127 15 modulating modulate VBG cord-252725-e3pazjdi 127 16 , , , cord-252725-e3pazjdi 127 17 anti anti JJ cord-252725-e3pazjdi 127 18 - - JJ cord-252725-e3pazjdi 127 19 inflammatory inflammatory JJ cord-252725-e3pazjdi 127 20 , , , cord-252725-e3pazjdi 127 21 anticancer anticancer JJ cord-252725-e3pazjdi 127 22 , , , cord-252725-e3pazjdi 127 23 antimicrobial antimicrobial JJ cord-252725-e3pazjdi 127 24 , , , cord-252725-e3pazjdi 127 25 antiviral antiviral JJ cord-252725-e3pazjdi 127 26 , , , cord-252725-e3pazjdi 127 27 anti anti JJ cord-252725-e3pazjdi 127 28 - - JJ cord-252725-e3pazjdi 127 29 oxidant oxidant JJ cord-252725-e3pazjdi 127 30 , , , cord-252725-e3pazjdi 127 31 anti anti JJ cord-252725-e3pazjdi 127 32 - - JJ cord-252725-e3pazjdi 127 33 allergic allergic JJ cord-252725-e3pazjdi 127 34 and and CC cord-252725-e3pazjdi 127 35 neuroprotective neuroprotective JJ cord-252725-e3pazjdi 127 36 activities activity NNS cord-252725-e3pazjdi 127 37 [ [ -LRB- cord-252725-e3pazjdi 127 38 86 86 CD cord-252725-e3pazjdi 127 39 , , , cord-252725-e3pazjdi 127 40 87 87 CD cord-252725-e3pazjdi 127 41 ] ] -RRB- cord-252725-e3pazjdi 127 42 . . . cord-252725-e3pazjdi 128 1 Luteolin Luteolin NNP cord-252725-e3pazjdi 128 2 suppressed suppress VBD cord-252725-e3pazjdi 128 3 LPS LPS NNP cord-252725-e3pazjdi 128 4 - - HYPH cord-252725-e3pazjdi 128 5 elicited elicit VBN cord-252725-e3pazjdi 128 6 inflammatory inflammatory JJ cord-252725-e3pazjdi 128 7 events event NNS cord-252725-e3pazjdi 128 8 in in IN cord-252725-e3pazjdi 128 9 mouse mouse NN cord-252725-e3pazjdi 128 10 alveolar alveolar NN cord-252725-e3pazjdi 128 11 macrophages macrophage NNS cord-252725-e3pazjdi 128 12 including include VBG cord-252725-e3pazjdi 128 13 COX2 COX2 NNP cord-252725-e3pazjdi 128 14 , , , cord-252725-e3pazjdi 128 15 the the DT cord-252725-e3pazjdi 128 16 secretion secretion NN cord-252725-e3pazjdi 128 17 of of IN cord-252725-e3pazjdi 128 18 the the DT cord-252725-e3pazjdi 128 19 pro pro JJ cord-252725-e3pazjdi 128 20 - - JJ cord-252725-e3pazjdi 128 21 inflammatory inflammatory JJ cord-252725-e3pazjdi 128 22 agents agent NNS cord-252725-e3pazjdi 128 23 , , , cord-252725-e3pazjdi 128 24 TNF TNF NNP cord-252725-e3pazjdi 128 25 - - HYPH cord-252725-e3pazjdi 128 26 α α NNP cord-252725-e3pazjdi 128 27 , , , cord-252725-e3pazjdi 128 28 IL-6 IL-6 NNP cord-252725-e3pazjdi 128 29 and and CC cord-252725-e3pazjdi 128 30 iNOS iNOS NNP cord-252725-e3pazjdi 128 31 and and CC cord-252725-e3pazjdi 128 32 ROS ROS NNP cord-252725-e3pazjdi 128 33 production production NN cord-252725-e3pazjdi 128 34 was be VBD cord-252725-e3pazjdi 128 35 blocked block VBN cord-252725-e3pazjdi 128 36 by by IN cord-252725-e3pazjdi 128 37 repressing repress VBG cord-252725-e3pazjdi 128 38 NF nf NN cord-252725-e3pazjdi 128 39 - - HYPH cord-252725-e3pazjdi 128 40 κB κB NNP cord-252725-e3pazjdi 128 41 and and CC cord-252725-e3pazjdi 128 42 AP-1 AP-1 NNP cord-252725-e3pazjdi 128 43 activation activation NN cord-252725-e3pazjdi 128 44 pathways pathway NNS cord-252725-e3pazjdi 128 45 , , , cord-252725-e3pazjdi 128 46 suggesting suggest VBG cord-252725-e3pazjdi 128 47 a a DT cord-252725-e3pazjdi 128 48 possible possible JJ cord-252725-e3pazjdi 128 49 therapeutic therapeutic JJ cord-252725-e3pazjdi 128 50 application application NN cord-252725-e3pazjdi 128 51 of of IN cord-252725-e3pazjdi 128 52 luteolin luteolin NN cord-252725-e3pazjdi 128 53 for for IN cord-252725-e3pazjdi 128 54 treating treat VBG cord-252725-e3pazjdi 128 55 lung lung NN cord-252725-e3pazjdi 128 56 inflammatory inflammatory JJ cord-252725-e3pazjdi 128 57 disorders disorder NNS cord-252725-e3pazjdi 128 58 [ [ -LRB- cord-252725-e3pazjdi 128 59 88 88 CD cord-252725-e3pazjdi 128 60 ] ] -RRB- cord-252725-e3pazjdi 128 61 . . . cord-252725-e3pazjdi 129 1 A a DT cord-252725-e3pazjdi 129 2 protection protection NN cord-252725-e3pazjdi 129 3 mechanism mechanism NN cord-252725-e3pazjdi 129 4 of of IN cord-252725-e3pazjdi 129 5 luteolin luteolin NN cord-252725-e3pazjdi 129 6 against against IN cord-252725-e3pazjdi 129 7 acute acute JJ cord-252725-e3pazjdi 129 8 lung lung NN cord-252725-e3pazjdi 129 9 injury injury NN cord-252725-e3pazjdi 129 10 induced induce VBN cord-252725-e3pazjdi 129 11 by by IN cord-252725-e3pazjdi 129 12 lipopolysaccharide lipopolysaccharide NN cord-252725-e3pazjdi 129 13 in in IN cord-252725-e3pazjdi 129 14 mice mouse NNS cord-252725-e3pazjdi 129 15 was be VBD cord-252725-e3pazjdi 129 16 suggested suggest VBN cord-252725-e3pazjdi 129 17 by by IN cord-252725-e3pazjdi 129 18 Akt Akt NNP cord-252725-e3pazjdi 129 19 / / SYM cord-252725-e3pazjdi 129 20 NFκB NFκB NNP cord-252725-e3pazjdi 129 21 inhibition inhibition NN cord-252725-e3pazjdi 129 22 pathway pathway NN cord-252725-e3pazjdi 129 23 [ [ -LRB- cord-252725-e3pazjdi 129 24 89 89 CD cord-252725-e3pazjdi 129 25 ] ] -RRB- cord-252725-e3pazjdi 129 26 . . . cord-252725-e3pazjdi 130 1 Similar similar JJ cord-252725-e3pazjdi 130 2 mechanism mechanism NN cord-252725-e3pazjdi 130 3 of of IN cord-252725-e3pazjdi 130 4 luteion luteion NN cord-252725-e3pazjdi 130 5 protection protection NN cord-252725-e3pazjdi 130 6 activity activity NN cord-252725-e3pazjdi 130 7 against against IN cord-252725-e3pazjdi 130 8 lipopolysaccharide lipopolysaccharide NN cord-252725-e3pazjdi 130 9 - - HYPH cord-252725-e3pazjdi 130 10 induced induce VBN cord-252725-e3pazjdi 130 11 acute acute JJ cord-252725-e3pazjdi 130 12 lung lung NN cord-252725-e3pazjdi 130 13 injury injury NN cord-252725-e3pazjdi 130 14 and and CC cord-252725-e3pazjdi 130 15 respiratory respiratory JJ cord-252725-e3pazjdi 130 16 burst burst NN cord-252725-e3pazjdi 130 17 involved involve VBN cord-252725-e3pazjdi 130 18 inhibition inhibition NN cord-252725-e3pazjdi 130 19 of of IN cord-252725-e3pazjdi 130 20 MEK MEK NNP cord-252725-e3pazjdi 130 21 / / SYM cord-252725-e3pazjdi 130 22 ERK ERK NNP cord-252725-e3pazjdi 130 23 and and CC cord-252725-e3pazjdi 131 1 PI3K PI3K NNP cord-252725-e3pazjdi 131 2 / / SYM cord-252725-e3pazjdi 131 3 Akt Akt NNP cord-252725-e3pazjdi 131 4 pathways pathway NNS cord-252725-e3pazjdi 131 5 was be VBD cord-252725-e3pazjdi 131 6 suggested suggest VBN cord-252725-e3pazjdi 131 7 in in IN cord-252725-e3pazjdi 131 8 neutrophils neutrophil NNS cord-252725-e3pazjdi 131 9 [ [ -LRB- cord-252725-e3pazjdi 131 10 90 90 CD cord-252725-e3pazjdi 131 11 ] ] -RRB- cord-252725-e3pazjdi 131 12 . . . cord-252725-e3pazjdi 132 1 Moreover moreover RB cord-252725-e3pazjdi 132 2 , , , cord-252725-e3pazjdi 132 3 luteolin luteolin NN cord-252725-e3pazjdi 132 4 inhibited inhibit VBN cord-252725-e3pazjdi 132 5 Epstein Epstein NNP cord-252725-e3pazjdi 132 6 - - HYPH cord-252725-e3pazjdi 132 7 Barr Barr NNP cord-252725-e3pazjdi 132 8 virus virus NN cord-252725-e3pazjdi 132 9 ( ( -LRB- cord-252725-e3pazjdi 132 10 EBV EBV NNP cord-252725-e3pazjdi 132 11 ) ) -RRB- cord-252725-e3pazjdi 132 12 reactivation reactivation NN cord-252725-e3pazjdi 132 13 by by IN cord-252725-e3pazjdi 132 14 repressing repress VBG cord-252725-e3pazjdi 132 15 the the DT cord-252725-e3pazjdi 132 16 immediate immediate JJ cord-252725-e3pazjdi 132 17 - - HYPH cord-252725-e3pazjdi 132 18 early early JJ cord-252725-e3pazjdi 132 19 genes gene NNS cord-252725-e3pazjdi 132 20 Zta Zta NNP cord-252725-e3pazjdi 132 21 ( ( -LRB- cord-252725-e3pazjdi 132 22 Zp Zp NNP cord-252725-e3pazjdi 132 23 ) ) -RRB- cord-252725-e3pazjdi 132 24 and and CC cord-252725-e3pazjdi 132 25 Rta Rta NNP cord-252725-e3pazjdi 132 26 ( ( -LRB- cord-252725-e3pazjdi 132 27 Rp Rp NNP cord-252725-e3pazjdi 132 28 ) ) -RRB- cord-252725-e3pazjdi 132 29 and and CC cord-252725-e3pazjdi 132 30 also also RB cord-252725-e3pazjdi 132 31 inhibited inhibited JJ cord-252725-e3pazjdi 132 32 Sp1-luc Sp1-luc NNS cord-252725-e3pazjdi 132 33 activity activity NN cord-252725-e3pazjdi 132 34 in in IN cord-252725-e3pazjdi 132 35 the the DT cord-252725-e3pazjdi 132 36 virus virus NN cord-252725-e3pazjdi 132 37 promoters promoter NNS cord-252725-e3pazjdi 132 38 , , , cord-252725-e3pazjdi 132 39 suggesting suggest VBG cord-252725-e3pazjdi 132 40 luteolin luteolin NNP cord-252725-e3pazjdi 132 41 is be VBZ cord-252725-e3pazjdi 132 42 a a DT cord-252725-e3pazjdi 132 43 potential potential JJ cord-252725-e3pazjdi 132 44 dietary dietary JJ cord-252725-e3pazjdi 132 45 compound compound NN cord-252725-e3pazjdi 132 46 for for IN cord-252725-e3pazjdi 132 47 prevention prevention NN cord-252725-e3pazjdi 132 48 of of IN cord-252725-e3pazjdi 132 49 virus virus NN cord-252725-e3pazjdi 132 50 infection infection NN cord-252725-e3pazjdi 132 51 [ [ -LRB- cord-252725-e3pazjdi 132 52 91 91 CD cord-252725-e3pazjdi 132 53 ] ] -RRB- cord-252725-e3pazjdi 132 54 . . . cord-252725-e3pazjdi 133 1 Furthermore furthermore RB cord-252725-e3pazjdi 133 2 , , , cord-252725-e3pazjdi 133 3 luteolin luteolin NNP cord-252725-e3pazjdi 133 4 has have VBZ cord-252725-e3pazjdi 133 5 been be VBN cord-252725-e3pazjdi 133 6 found find VBN cord-252725-e3pazjdi 133 7 to to TO cord-252725-e3pazjdi 133 8 be be VB cord-252725-e3pazjdi 133 9 a a DT cord-252725-e3pazjdi 133 10 potent potent JJ cord-252725-e3pazjdi 133 11 antifibrotic antifibrotic JJ cord-252725-e3pazjdi 133 12 activity activity NN cord-252725-e3pazjdi 133 13 as as IN cord-252725-e3pazjdi 133 14 it -PRON- PRP cord-252725-e3pazjdi 133 15 inhibits inhibit VBZ cord-252725-e3pazjdi 133 16 lung lung NN cord-252725-e3pazjdi 133 17 inflammation inflammation NN cord-252725-e3pazjdi 133 18 and and CC cord-252725-e3pazjdi 133 19 suppresses suppresse NNS cord-252725-e3pazjdi 133 20 of of IN cord-252725-e3pazjdi 133 21 myofibroblast myofibroblast JJ cord-252725-e3pazjdi 133 22 differentiation differentiation NN cord-252725-e3pazjdi 133 23 as as RB cord-252725-e3pazjdi 133 24 well well RB cord-252725-e3pazjdi 133 25 as as IN cord-252725-e3pazjdi 133 26 epithelial epithelial NN cord-252725-e3pazjdi 133 27 - - HYPH cord-252725-e3pazjdi 133 28 to to IN cord-252725-e3pazjdi 133 29 - - HYPH cord-252725-e3pazjdi 133 30 mesenchymal mesenchymal JJ cord-252725-e3pazjdi 133 31 transition transition NN cord-252725-e3pazjdi 133 32 [ [ -LRB- cord-252725-e3pazjdi 133 33 92 92 CD cord-252725-e3pazjdi 133 34 ] ] -RRB- cord-252725-e3pazjdi 133 35 . . . cord-252725-e3pazjdi 134 1 Anti anti JJ cord-252725-e3pazjdi 134 2 - - JJ cord-252725-e3pazjdi 134 3 asthmatic asthmatic JJ cord-252725-e3pazjdi 134 4 activity activity NN cord-252725-e3pazjdi 134 5 of of IN cord-252725-e3pazjdi 134 6 luteolin luteolin NN cord-252725-e3pazjdi 134 7 was be VBD cord-252725-e3pazjdi 134 8 also also RB cord-252725-e3pazjdi 134 9 reported report VBN cord-252725-e3pazjdi 134 10 in in IN cord-252725-e3pazjdi 134 11 experimental experimental JJ cord-252725-e3pazjdi 134 12 mice mouse NNS cord-252725-e3pazjdi 134 13 [ [ -LRB- cord-252725-e3pazjdi 134 14 93 93 CD cord-252725-e3pazjdi 134 15 ] ] -RRB- cord-252725-e3pazjdi 134 16 . . . cord-252725-e3pazjdi 135 1 In in IN cord-252725-e3pazjdi 135 2 addition addition NN cord-252725-e3pazjdi 135 3 , , , cord-252725-e3pazjdi 135 4 two two CD cord-252725-e3pazjdi 135 5 small small JJ cord-252725-e3pazjdi 135 6 molecules molecule NNS cord-252725-e3pazjdi 135 7 , , , cord-252725-e3pazjdi 135 8 tetra tetra NN cord-252725-e3pazjdi 135 9 - - HYPH cord-252725-e3pazjdi 135 10 O o NN cord-252725-e3pazjdi 135 11 - - HYPH cord-252725-e3pazjdi 135 12 galloyl galloyl NN cord-252725-e3pazjdi 135 13 - - HYPH cord-252725-e3pazjdi 135 14 β β NN cord-252725-e3pazjdi 135 15 - - HYPH cord-252725-e3pazjdi 135 16 d d NN cord-252725-e3pazjdi 135 17 - - HYPH cord-252725-e3pazjdi 135 18 glucose glucose NN cord-252725-e3pazjdi 135 19 ( ( -LRB- cord-252725-e3pazjdi 135 20 TGG TGG NNP cord-252725-e3pazjdi 135 21 ) ) -RRB- cord-252725-e3pazjdi 135 22 and and CC cord-252725-e3pazjdi 135 23 luteolin luteolin NN cord-252725-e3pazjdi 135 24 , , , cord-252725-e3pazjdi 135 25 were be VBD cord-252725-e3pazjdi 135 26 identified identify VBN cord-252725-e3pazjdi 135 27 , , , cord-252725-e3pazjdi 135 28 whose whose WP$ cord-252725-e3pazjdi 135 29 anti anti JJ cord-252725-e3pazjdi 135 30 - - JJ cord-252725-e3pazjdi 135 31 SARS SARS NNP cord-252725-e3pazjdi 135 32 - - HYPH cord-252725-e3pazjdi 135 33 CoV CoV NNP cord-252725-e3pazjdi 135 34 activities activity NNS cord-252725-e3pazjdi 135 35 were be VBD cord-252725-e3pazjdi 135 36 confirmed confirm VBN cord-252725-e3pazjdi 135 37 using use VBG cord-252725-e3pazjdi 135 38 a a DT cord-252725-e3pazjdi 135 39 wild wild JJ cord-252725-e3pazjdi 135 40 - - HYPH cord-252725-e3pazjdi 135 41 type type NN cord-252725-e3pazjdi 135 42 SARS SARS NNP cord-252725-e3pazjdi 135 43 - - HYPH cord-252725-e3pazjdi 135 44 CoV CoV NNP cord-252725-e3pazjdi 135 45 infection infection NN cord-252725-e3pazjdi 135 46 system system NN cord-252725-e3pazjdi 135 47 . . . cord-252725-e3pazjdi 136 1 Both both DT cord-252725-e3pazjdi 136 2 TGG TGG NNP cord-252725-e3pazjdi 136 3 and and CC cord-252725-e3pazjdi 136 4 luteolin luteolin NNP cord-252725-e3pazjdi 136 5 showed show VBD cord-252725-e3pazjdi 136 6 at at IN cord-252725-e3pazjdi 136 7 the the DT cord-252725-e3pazjdi 136 8 same same JJ cord-252725-e3pazjdi 136 9 concentration concentration NN cord-252725-e3pazjdi 136 10 levels level NNS cord-252725-e3pazjdi 136 11 to to TO cord-252725-e3pazjdi 136 12 effectively effectively RB cord-252725-e3pazjdi 136 13 inhibit inhibit VB cord-252725-e3pazjdi 136 14 the the DT cord-252725-e3pazjdi 136 15 entry entry NN cord-252725-e3pazjdi 136 16 of of IN cord-252725-e3pazjdi 136 17 HIV HIV NNP cord-252725-e3pazjdi 136 18 - - HYPH cord-252725-e3pazjdi 136 19 luc luc NNP cord-252725-e3pazjdi 136 20 / / SYM cord-252725-e3pazjdi 136 21 SARS SARS NNP cord-252725-e3pazjdi 136 22 pseudo pseudo NN cord-252725-e3pazjdi 136 23 typed type VBD cord-252725-e3pazjdi 136 24 virus virus NN cord-252725-e3pazjdi 136 25 into into IN cord-252725-e3pazjdi 136 26 its -PRON- PRP$ cord-252725-e3pazjdi 136 27 host host NN cord-252725-e3pazjdi 136 28 , , , cord-252725-e3pazjdi 136 29 which which WDT cord-252725-e3pazjdi 136 30 suggests suggest VBZ cord-252725-e3pazjdi 136 31 a a DT cord-252725-e3pazjdi 136 32 potential potential JJ cord-252725-e3pazjdi 136 33 clinical clinical JJ cord-252725-e3pazjdi 136 34 use use NN cord-252725-e3pazjdi 136 35 of of IN cord-252725-e3pazjdi 136 36 these these DT cord-252725-e3pazjdi 136 37 two two CD cord-252725-e3pazjdi 136 38 molecules molecule NNS cord-252725-e3pazjdi 136 39 as as IN cord-252725-e3pazjdi 136 40 anti anti JJ cord-252725-e3pazjdi 136 41 - - JJ cord-252725-e3pazjdi 136 42 SARS sars JJ cord-252725-e3pazjdi 136 43 drugs drug NNS cord-252725-e3pazjdi 136 44 [ [ -LRB- cord-252725-e3pazjdi 136 45 41 41 CD cord-252725-e3pazjdi 136 46 , , , cord-252725-e3pazjdi 136 47 94 94 CD cord-252725-e3pazjdi 136 48 ] ] -RRB- cord-252725-e3pazjdi 136 49 . . . cord-252725-e3pazjdi 137 1 Consequently consequently RB cord-252725-e3pazjdi 137 2 , , , cord-252725-e3pazjdi 137 3 luteolin luteolin NNP cord-252725-e3pazjdi 137 4 could could MD cord-252725-e3pazjdi 137 5 be be VB cord-252725-e3pazjdi 137 6 selected select VBN cord-252725-e3pazjdi 137 7 as as IN cord-252725-e3pazjdi 137 8 an an DT cord-252725-e3pazjdi 137 9 alternative alternative JJ cord-252725-e3pazjdi 137 10 treatment treatment NN cord-252725-e3pazjdi 137 11 or or CC cord-252725-e3pazjdi 137 12 body body NN cord-252725-e3pazjdi 137 13 immunity immunity NN cord-252725-e3pazjdi 137 14 enhancer enhancer NN cord-252725-e3pazjdi 137 15 against against IN cord-252725-e3pazjdi 137 16 COVID-19 covid-19 JJ cord-252725-e3pazjdi 137 17 infection infection NN cord-252725-e3pazjdi 137 18 due due IN cord-252725-e3pazjdi 137 19 to to IN cord-252725-e3pazjdi 137 20 its -PRON- PRP$ cord-252725-e3pazjdi 137 21 strong strong JJ cord-252725-e3pazjdi 137 22 anti anti JJ cord-252725-e3pazjdi 137 23 - - JJ cord-252725-e3pazjdi 137 24 viral viral JJ cord-252725-e3pazjdi 137 25 and and CC cord-252725-e3pazjdi 137 26 anti anti JJ cord-252725-e3pazjdi 137 27 - - JJ cord-252725-e3pazjdi 137 28 inflammatory inflammatory JJ cord-252725-e3pazjdi 137 29 properties property NNS cord-252725-e3pazjdi 137 30 during during IN cord-252725-e3pazjdi 137 31 infection infection NN cord-252725-e3pazjdi 137 32 . . . cord-252725-e3pazjdi 138 1 Genistein Genistein NNP cord-252725-e3pazjdi 138 2 ( ( -LRB- cord-252725-e3pazjdi 138 3 4′,5,7-trihydroxyflavone 4′,5,7-trihydroxyflavone CD cord-252725-e3pazjdi 138 4 ) ) -RRB- cord-252725-e3pazjdi 139 1 ( ( -LRB- cord-252725-e3pazjdi 139 2 Fig Fig NNP cord-252725-e3pazjdi 139 3 . . . cord-252725-e3pazjdi 139 4 8) 8) NNP cord-252725-e3pazjdi 139 5 , , , cord-252725-e3pazjdi 139 6 is be VBZ cord-252725-e3pazjdi 139 7 a a DT cord-252725-e3pazjdi 139 8 naturally naturally RB cord-252725-e3pazjdi 139 9 occurring occur VBG cord-252725-e3pazjdi 139 10 phytoestrogen phytoestrogen NN cord-252725-e3pazjdi 139 11 found find VBN cord-252725-e3pazjdi 139 12 mainly mainly RB cord-252725-e3pazjdi 139 13 in in IN cord-252725-e3pazjdi 139 14 soy soy NN cord-252725-e3pazjdi 139 15 foods food NNS cord-252725-e3pazjdi 139 16 and and CC cord-252725-e3pazjdi 139 17 legumes legume NNS cord-252725-e3pazjdi 139 18 including include VBG cord-252725-e3pazjdi 139 19 peas pea NNS cord-252725-e3pazjdi 139 20 , , , cord-252725-e3pazjdi 139 21 lentils lentil NNS cord-252725-e3pazjdi 139 22 or or CC cord-252725-e3pazjdi 139 23 beans bean NNS cord-252725-e3pazjdi 139 24 , , , cord-252725-e3pazjdi 139 25 fava fava NN cord-252725-e3pazjdi 139 26 beans bean NNS cord-252725-e3pazjdi 139 27 , , , cord-252725-e3pazjdi 139 28 lupin lupin NNP cord-252725-e3pazjdi 139 29 , , , cord-252725-e3pazjdi 139 30 tofu tofu NN cord-252725-e3pazjdi 139 31 , , , cord-252725-e3pazjdi 139 32 kudzu kudzu NN cord-252725-e3pazjdi 139 33 , , , cord-252725-e3pazjdi 139 34 psoralea psoralea NNP cord-252725-e3pazjdi 139 35 , , , cord-252725-e3pazjdi 139 36 red red JJ cord-252725-e3pazjdi 139 37 clover clover NN cord-252725-e3pazjdi 139 38 , , , cord-252725-e3pazjdi 139 39 coffee coffee NN cord-252725-e3pazjdi 139 40 and and CC cord-252725-e3pazjdi 139 41 some some DT cord-252725-e3pazjdi 139 42 medical medical JJ cord-252725-e3pazjdi 139 43 plants plant NNS cord-252725-e3pazjdi 139 44 such such JJ cord-252725-e3pazjdi 139 45 as as IN cord-252725-e3pazjdi 139 46 Flemingia Flemingia NNP cord-252725-e3pazjdi 139 47 vestita vestita NNPS cord-252725-e3pazjdi 139 48 and and CC cord-252725-e3pazjdi 139 49 Flemingia Flemingia NNP cord-252725-e3pazjdi 139 50 macrophylla macrophylla NN cord-252725-e3pazjdi 139 51 root root NN cord-252725-e3pazjdi 139 52 , , , cord-252725-e3pazjdi 139 53 [ [ -LRB- cord-252725-e3pazjdi 139 54 96 96 CD cord-252725-e3pazjdi 139 55 ] ] -RRB- cord-252725-e3pazjdi 139 56 . . . cord-252725-e3pazjdi 140 1 Genistein Genistein NNP cord-252725-e3pazjdi 140 2 possesses possess VBZ cord-252725-e3pazjdi 140 3 many many JJ cord-252725-e3pazjdi 140 4 therapeutic therapeutic JJ cord-252725-e3pazjdi 140 5 uses use NNS cord-252725-e3pazjdi 140 6 against against IN cord-252725-e3pazjdi 140 7 numerous numerous JJ cord-252725-e3pazjdi 140 8 disorders disorder NNS cord-252725-e3pazjdi 140 9 including include VBG cord-252725-e3pazjdi 140 10 osteoporosis osteoporosis NN cord-252725-e3pazjdi 140 11 , , , cord-252725-e3pazjdi 140 12 cardiovascular cardiovascular JJ cord-252725-e3pazjdi 140 13 diseases disease NNS cord-252725-e3pazjdi 140 14 , , , cord-252725-e3pazjdi 140 15 a a DT cord-252725-e3pazjdi 140 16 variety variety NN cord-252725-e3pazjdi 140 17 of of IN cord-252725-e3pazjdi 140 18 tumors tumor NNS cord-252725-e3pazjdi 140 19 , , , cord-252725-e3pazjdi 140 20 diabetes diabetes NN cord-252725-e3pazjdi 140 21 , , , cord-252725-e3pazjdi 140 22 inflammation inflammation NN cord-252725-e3pazjdi 140 23 , , , cord-252725-e3pazjdi 140 24 oxidative oxidative JJ cord-252725-e3pazjdi 140 25 stress stress NN cord-252725-e3pazjdi 140 26 and and CC cord-252725-e3pazjdi 140 27 metabolic metabolic JJ cord-252725-e3pazjdi 140 28 syndromes syndrome NNS cord-252725-e3pazjdi 140 29 . . . cord-252725-e3pazjdi 141 1 Genistein Genistein NNP cord-252725-e3pazjdi 141 2 was be VBD cord-252725-e3pazjdi 141 3 successfully successfully RB cord-252725-e3pazjdi 141 4 used use VBN cord-252725-e3pazjdi 141 5 as as IN cord-252725-e3pazjdi 141 6 an an DT cord-252725-e3pazjdi 141 7 immune immune JJ cord-252725-e3pazjdi 141 8 - - HYPH cord-252725-e3pazjdi 141 9 suppressive suppressive JJ cord-252725-e3pazjdi 141 10 agent agent NN cord-252725-e3pazjdi 141 11 both both CC cord-252725-e3pazjdi 141 12 in in IN cord-252725-e3pazjdi 141 13 vitro vitro FW cord-252725-e3pazjdi 141 14 and and CC cord-252725-e3pazjdi 141 15 in in IN cord-252725-e3pazjdi 141 16 vivo vivo NNP cord-252725-e3pazjdi 141 17 [ [ -LRB- cord-252725-e3pazjdi 141 18 97 97 CD cord-252725-e3pazjdi 141 19 ] ] -RRB- cord-252725-e3pazjdi 141 20 due due IN cord-252725-e3pazjdi 141 21 to to IN cord-252725-e3pazjdi 141 22 its -PRON- PRP$ cord-252725-e3pazjdi 141 23 ability ability NN cord-252725-e3pazjdi 141 24 to to TO cord-252725-e3pazjdi 141 25 inhibit inhibit VB cord-252725-e3pazjdi 141 26 the the DT cord-252725-e3pazjdi 141 27 infectivity infectivity NN cord-252725-e3pazjdi 141 28 of of IN cord-252725-e3pazjdi 141 29 enveloped enveloped JJ cord-252725-e3pazjdi 141 30 or or CC cord-252725-e3pazjdi 141 31 non non JJ cord-252725-e3pazjdi 141 32 - - JJ cord-252725-e3pazjdi 141 33 enveloped enveloped JJ cord-252725-e3pazjdi 141 34 viruses virus NNS cord-252725-e3pazjdi 141 35 , , , cord-252725-e3pazjdi 141 36 as as RB cord-252725-e3pazjdi 141 37 well well RB cord-252725-e3pazjdi 141 38 as as IN cord-252725-e3pazjdi 141 39 single single JJ cord-252725-e3pazjdi 141 40 or or CC cord-252725-e3pazjdi 141 41 double double RB cord-252725-e3pazjdi 141 42 - - HYPH cord-252725-e3pazjdi 141 43 stranded strand VBN cord-252725-e3pazjdi 141 44 RNA RNA NNP cord-252725-e3pazjdi 141 45 or or CC cord-252725-e3pazjdi 141 46 DNA dna NN cord-252725-e3pazjdi 141 47 viruses virus NNS cord-252725-e3pazjdi 141 48 by by IN cord-252725-e3pazjdi 141 49 different different JJ cord-252725-e3pazjdi 141 50 mechanisms mechanism NNS cord-252725-e3pazjdi 141 51 . . . cord-252725-e3pazjdi 142 1 Genistein Genistein NNP cord-252725-e3pazjdi 142 2 has have VBZ cord-252725-e3pazjdi 142 3 been be VBN cord-252725-e3pazjdi 142 4 shown show VBN cord-252725-e3pazjdi 142 5 to to TO cord-252725-e3pazjdi 142 6 reduce reduce VB cord-252725-e3pazjdi 142 7 the the DT cord-252725-e3pazjdi 142 8 infectivity infectivity NN cord-252725-e3pazjdi 142 9 of of IN cord-252725-e3pazjdi 142 10 a a DT cord-252725-e3pazjdi 142 11 variety variety NN cord-252725-e3pazjdi 142 12 of of IN cord-252725-e3pazjdi 142 13 viruses virus NNS cord-252725-e3pazjdi 142 14 affecting affect VBG cord-252725-e3pazjdi 142 15 humans human NNS cord-252725-e3pazjdi 142 16 and and CC cord-252725-e3pazjdi 142 17 animals animal NNS cord-252725-e3pazjdi 142 18 , , , cord-252725-e3pazjdi 142 19 including include VBG cord-252725-e3pazjdi 142 20 adenovirus adenovirus NN cord-252725-e3pazjdi 142 21 , , , cord-252725-e3pazjdi 142 22 herpes herpes NN cord-252725-e3pazjdi 142 23 simplex simplex NNP cord-252725-e3pazjdi 142 24 virus virus NN cord-252725-e3pazjdi 142 25 , , , cord-252725-e3pazjdi 142 26 human human JJ cord-252725-e3pazjdi 142 27 immunodeficiency immunodeficiency NN cord-252725-e3pazjdi 142 28 virus virus NN cord-252725-e3pazjdi 142 29 , , , cord-252725-e3pazjdi 142 30 porcine porcine JJ cord-252725-e3pazjdi 142 31 reproductive reproductive JJ cord-252725-e3pazjdi 142 32 and and CC cord-252725-e3pazjdi 142 33 respiratory respiratory JJ cord-252725-e3pazjdi 142 34 syndrome syndrome NN cord-252725-e3pazjdi 142 35 virus virus NN cord-252725-e3pazjdi 142 36 , , , cord-252725-e3pazjdi 142 37 and and CC cord-252725-e3pazjdi 142 38 rotavirus rotavirus NN cord-252725-e3pazjdi 142 39 [ [ -LRB- cord-252725-e3pazjdi 142 40 98 98 CD cord-252725-e3pazjdi 142 41 ] ] -RRB- cord-252725-e3pazjdi 142 42 . . . cord-252725-e3pazjdi 143 1 An an DT cord-252725-e3pazjdi 143 2 ethyl ethyl NN cord-252725-e3pazjdi 143 3 acetate acetate NN cord-252725-e3pazjdi 143 4 extract extract NN cord-252725-e3pazjdi 143 5 from from IN cord-252725-e3pazjdi 143 6 Chongkukjang Chongkukjang NNP cord-252725-e3pazjdi 143 7 , , , cord-252725-e3pazjdi 143 8 a a DT cord-252725-e3pazjdi 143 9 traditional traditional JJ cord-252725-e3pazjdi 143 10 Korean korean JJ cord-252725-e3pazjdi 143 11 fermented fermented JJ cord-252725-e3pazjdi 143 12 product product NN cord-252725-e3pazjdi 143 13 prepared prepare VBN cord-252725-e3pazjdi 143 14 from from IN cord-252725-e3pazjdi 143 15 soybeans soybean NNS cord-252725-e3pazjdi 143 16 , , , cord-252725-e3pazjdi 143 17 was be VBD cord-252725-e3pazjdi 143 18 shown show VBN cord-252725-e3pazjdi 143 19 as as IN cord-252725-e3pazjdi 143 20 an an DT cord-252725-e3pazjdi 143 21 effective effective JJ cord-252725-e3pazjdi 143 22 therapeutic therapeutic JJ cord-252725-e3pazjdi 143 23 agent agent NN cord-252725-e3pazjdi 143 24 to to TO cord-252725-e3pazjdi 143 25 treat treat VB cord-252725-e3pazjdi 143 26 influenza influenza NN cord-252725-e3pazjdi 143 27 A a DT cord-252725-e3pazjdi 143 28 virus virus NN cord-252725-e3pazjdi 143 29 infection infection NN cord-252725-e3pazjdi 143 30 [ [ -LRB- cord-252725-e3pazjdi 143 31 99 99 CD cord-252725-e3pazjdi 143 32 ] ] -RRB- cord-252725-e3pazjdi 143 33 . . . cord-252725-e3pazjdi 144 1 Moreover moreover RB cord-252725-e3pazjdi 144 2 , , , cord-252725-e3pazjdi 144 3 genistein genistein NNP cord-252725-e3pazjdi 144 4 was be VBD cord-252725-e3pazjdi 144 5 also also RB cord-252725-e3pazjdi 144 6 effective effective JJ cord-252725-e3pazjdi 144 7 against against IN cord-252725-e3pazjdi 144 8 the the DT cord-252725-e3pazjdi 144 9 ionic ionic JJ cord-252725-e3pazjdi 144 10 channel channel NN cord-252725-e3pazjdi 144 11 of of IN cord-252725-e3pazjdi 144 12 HIV HIV NNP cord-252725-e3pazjdi 144 13 , , , cord-252725-e3pazjdi 144 14 which which WDT cord-252725-e3pazjdi 144 15 is be VBZ cord-252725-e3pazjdi 144 16 supposed suppose VBN cord-252725-e3pazjdi 144 17 to to TO cord-252725-e3pazjdi 144 18 form form VB cord-252725-e3pazjdi 144 19 a a DT cord-252725-e3pazjdi 144 20 cation cation NN cord-252725-e3pazjdi 144 21 - - HYPH cord-252725-e3pazjdi 144 22 permeable permeable JJ cord-252725-e3pazjdi 144 23 ion ion NN cord-252725-e3pazjdi 144 24 channel channel NN cord-252725-e3pazjdi 144 25 in in IN cord-252725-e3pazjdi 144 26 the the DT cord-252725-e3pazjdi 144 27 infected infected JJ cord-252725-e3pazjdi 144 28 cell cell NN cord-252725-e3pazjdi 144 29 [ [ -LRB- cord-252725-e3pazjdi 144 30 105 105 CD cord-252725-e3pazjdi 144 31 ] ] -RRB- cord-252725-e3pazjdi 144 32 . . . cord-252725-e3pazjdi 145 1 Genistein Genistein NNP cord-252725-e3pazjdi 145 2 may may MD cord-252725-e3pazjdi 145 3 be be VB cord-252725-e3pazjdi 145 4 also also RB cord-252725-e3pazjdi 145 5 a a DT cord-252725-e3pazjdi 145 6 useful useful JJ cord-252725-e3pazjdi 145 7 candidate candidate NN cord-252725-e3pazjdi 145 8 for for IN cord-252725-e3pazjdi 145 9 developing develop VBG cord-252725-e3pazjdi 145 10 a a DT cord-252725-e3pazjdi 145 11 new new JJ cord-252725-e3pazjdi 145 12 anti anti JJ cord-252725-e3pazjdi 145 13 - - JJ cord-252725-e3pazjdi 145 14 rotavirus rotavirus JJ cord-252725-e3pazjdi 145 15 ( ( -LRB- cord-252725-e3pazjdi 145 16 RV rv NN cord-252725-e3pazjdi 145 17 ) ) -RRB- cord-252725-e3pazjdi 145 18 by by IN cord-252725-e3pazjdi 145 19 inhibiting inhibit VBG cord-252725-e3pazjdi 145 20 rotavirus rotavirus JJ cord-252725-e3pazjdi 145 21 replication replication NN cord-252725-e3pazjdi 145 22 and and CC cord-252725-e3pazjdi 145 23 upregulating upregulate VBG cord-252725-e3pazjdi 145 24 aquaporin aquaporin NNP cord-252725-e3pazjdi 145 25 4 4 CD cord-252725-e3pazjdi 145 26 ( ( -LRB- cord-252725-e3pazjdi 145 27 AQP4 AQP4 NNP cord-252725-e3pazjdi 145 28 ) ) -RRB- cord-252725-e3pazjdi 145 29 expression expression NN cord-252725-e3pazjdi 145 30 via via IN cord-252725-e3pazjdi 145 31 the the DT cord-252725-e3pazjdi 145 32 cAMP camp NN cord-252725-e3pazjdi 145 33 / / SYM cord-252725-e3pazjdi 145 34 PKA PKA NNP cord-252725-e3pazjdi 145 35 / / SYM cord-252725-e3pazjdi 145 36 CREB CREB NNP cord-252725-e3pazjdi 145 37 signaling signal VBG cord-252725-e3pazjdi 145 38 pathway pathway NN cord-252725-e3pazjdi 145 39 [ [ -LRB- cord-252725-e3pazjdi 145 40 100 100 CD cord-252725-e3pazjdi 145 41 ] ] -RRB- cord-252725-e3pazjdi 145 42 . . . cord-252725-e3pazjdi 146 1 A a DT cord-252725-e3pazjdi 146 2 study study NN cord-252725-e3pazjdi 146 3 has have VBZ cord-252725-e3pazjdi 146 4 reported report VBN cord-252725-e3pazjdi 146 5 that that IN cord-252725-e3pazjdi 146 6 an an DT cord-252725-e3pazjdi 146 7 increasing increase VBG cord-252725-e3pazjdi 146 8 consumption consumption NN cord-252725-e3pazjdi 146 9 of of IN cord-252725-e3pazjdi 146 10 genistein genistein NN cord-252725-e3pazjdi 146 11 or or CC cord-252725-e3pazjdi 146 12 a a DT cord-252725-e3pazjdi 146 13 diet diet NN cord-252725-e3pazjdi 146 14 with with IN cord-252725-e3pazjdi 146 15 moderate moderate JJ cord-252725-e3pazjdi 146 16 to to IN cord-252725-e3pazjdi 146 17 high high JJ cord-252725-e3pazjdi 146 18 amounts amount NNS cord-252725-e3pazjdi 146 19 of of IN cord-252725-e3pazjdi 146 20 soy soy NN cord-252725-e3pazjdi 146 21 genistein genistein WP cord-252725-e3pazjdi 146 22 is be VBZ cord-252725-e3pazjdi 146 23 associated associate VBN cord-252725-e3pazjdi 146 24 with with IN cord-252725-e3pazjdi 146 25 a a DT cord-252725-e3pazjdi 146 26 better well JJR cord-252725-e3pazjdi 146 27 lung lung NN cord-252725-e3pazjdi 146 28 function function NN cord-252725-e3pazjdi 146 29 in in IN cord-252725-e3pazjdi 146 30 patients patient NNS cord-252725-e3pazjdi 146 31 with with IN cord-252725-e3pazjdi 146 32 asthma asthma NN cord-252725-e3pazjdi 146 33 [ [ -LRB- cord-252725-e3pazjdi 146 34 101 101 CD cord-252725-e3pazjdi 146 35 ] ] -RRB- cord-252725-e3pazjdi 146 36 . . . cord-252725-e3pazjdi 147 1 The the DT cord-252725-e3pazjdi 147 2 African african JJ cord-252725-e3pazjdi 147 3 swine swine NN cord-252725-e3pazjdi 147 4 fever fever NN cord-252725-e3pazjdi 147 5 virus virus NN cord-252725-e3pazjdi 147 6 ( ( -LRB- cord-252725-e3pazjdi 147 7 ASFV ASFV NNP cord-252725-e3pazjdi 147 8 ) ) -RRB- cord-252725-e3pazjdi 147 9 was be VBD cord-252725-e3pazjdi 147 10 inhibited inhibit VBN cord-252725-e3pazjdi 147 11 in in IN cord-252725-e3pazjdi 147 12 vitro vitro FW cord-252725-e3pazjdi 147 13 by by IN cord-252725-e3pazjdi 147 14 genistein genistein VBG cord-252725-e3pazjdi 147 15 through through IN cord-252725-e3pazjdi 147 16 disrupting disrupt VBG cord-252725-e3pazjdi 147 17 the the DT cord-252725-e3pazjdi 147 18 viral viral JJ cord-252725-e3pazjdi 147 19 DNA dna NN cord-252725-e3pazjdi 147 20 replication replication NN cord-252725-e3pazjdi 147 21 , , , cord-252725-e3pazjdi 147 22 blocking block VBG cord-252725-e3pazjdi 147 23 the the DT cord-252725-e3pazjdi 147 24 transcription transcription NN cord-252725-e3pazjdi 147 25 of of IN cord-252725-e3pazjdi 147 26 late late JJ cord-252725-e3pazjdi 147 27 viral viral JJ cord-252725-e3pazjdi 147 28 genes gene NNS cord-252725-e3pazjdi 147 29 as as RB cord-252725-e3pazjdi 147 30 well well RB cord-252725-e3pazjdi 147 31 as as IN cord-252725-e3pazjdi 147 32 the the DT cord-252725-e3pazjdi 147 33 synthesis synthesis NN cord-252725-e3pazjdi 147 34 of of IN cord-252725-e3pazjdi 147 35 late late JJ cord-252725-e3pazjdi 147 36 viral viral JJ cord-252725-e3pazjdi 147 37 proteins protein NNS cord-252725-e3pazjdi 147 38 [ [ -LRB- cord-252725-e3pazjdi 147 39 102 102 CD cord-252725-e3pazjdi 147 40 ] ] -RRB- cord-252725-e3pazjdi 147 41 . . . cord-252725-e3pazjdi 148 1 It -PRON- PRP cord-252725-e3pazjdi 148 2 has have VBZ cord-252725-e3pazjdi 148 3 been be VBN cord-252725-e3pazjdi 148 4 demonstrated demonstrate VBN cord-252725-e3pazjdi 148 5 that that IN cord-252725-e3pazjdi 148 6 pre pre JJ cord-252725-e3pazjdi 148 7 - - NN cord-252725-e3pazjdi 148 8 treatment treatment NN cord-252725-e3pazjdi 148 9 of of IN cord-252725-e3pazjdi 148 10 host host NN cord-252725-e3pazjdi 148 11 cells cell NNS cord-252725-e3pazjdi 148 12 with with IN cord-252725-e3pazjdi 148 13 the the DT cord-252725-e3pazjdi 148 14 kinase kinase NN cord-252725-e3pazjdi 148 15 inhibitors inhibitor NNS cord-252725-e3pazjdi 148 16 ( ( -LRB- cord-252725-e3pazjdi 148 17 genistein genistein NN cord-252725-e3pazjdi 148 18 and and CC cord-252725-e3pazjdi 148 19 tyrphostin tyrphostin NNP cord-252725-e3pazjdi 148 20 ) ) -RRB- cord-252725-e3pazjdi 148 21 leads lead VBZ cord-252725-e3pazjdi 148 22 to to IN cord-252725-e3pazjdi 148 23 an an DT cord-252725-e3pazjdi 148 24 inhibition inhibition NN cord-252725-e3pazjdi 148 25 of of IN cord-252725-e3pazjdi 148 26 infection infection NN cord-252725-e3pazjdi 148 27 or or CC cord-252725-e3pazjdi 148 28 transduction transduction NN cord-252725-e3pazjdi 148 29 in in IN cord-252725-e3pazjdi 148 30 cells cell NNS cord-252725-e3pazjdi 148 31 infected infect VBN cord-252725-e3pazjdi 148 32 with with IN cord-252725-e3pazjdi 148 33 Ebola Ebola NNP cord-252725-e3pazjdi 148 34 virus virus NN cord-252725-e3pazjdi 148 35 , , , cord-252725-e3pazjdi 148 36 Marburg Marburg NNP cord-252725-e3pazjdi 148 37 virus virus NN cord-252725-e3pazjdi 148 38 , , , cord-252725-e3pazjdi 148 39 and and CC cord-252725-e3pazjdi 148 40 Lassa Lassa NNP cord-252725-e3pazjdi 148 41 virus virus NN cord-252725-e3pazjdi 148 42 [ [ -LRB- cord-252725-e3pazjdi 148 43 103 103 CD cord-252725-e3pazjdi 148 44 ] ] -RRB- cord-252725-e3pazjdi 148 45 . . . cord-252725-e3pazjdi 149 1 Therefore therefore RB cord-252725-e3pazjdi 149 2 , , , cord-252725-e3pazjdi 149 3 the the DT cord-252725-e3pazjdi 149 4 strong strong JJ cord-252725-e3pazjdi 149 5 influence influence NN cord-252725-e3pazjdi 149 6 of of IN cord-252725-e3pazjdi 149 7 genistein genistein NNP cord-252725-e3pazjdi 149 8 as as IN cord-252725-e3pazjdi 149 9 an an DT cord-252725-e3pazjdi 149 10 antiviral antiviral JJ cord-252725-e3pazjdi 149 11 agent agent NN cord-252725-e3pazjdi 149 12 against against IN cord-252725-e3pazjdi 149 13 different different JJ cord-252725-e3pazjdi 149 14 kinds kind NNS cord-252725-e3pazjdi 149 15 of of IN cord-252725-e3pazjdi 149 16 virus virus NN cord-252725-e3pazjdi 149 17 infections infection NNS cord-252725-e3pazjdi 149 18 may may MD cord-252725-e3pazjdi 149 19 promote promote VB cord-252725-e3pazjdi 149 20 its -PRON- PRP$ cord-252725-e3pazjdi 149 21 use use NN cord-252725-e3pazjdi 149 22 as as IN cord-252725-e3pazjdi 149 23 a a DT cord-252725-e3pazjdi 149 24 potential potential JJ cord-252725-e3pazjdi 149 25 candidate candidate NN cord-252725-e3pazjdi 149 26 for for IN cord-252725-e3pazjdi 149 27 defeating defeat VBG cord-252725-e3pazjdi 149 28 COVID-19 covid-19 VB cord-252725-e3pazjdi 149 29 and and CC cord-252725-e3pazjdi 149 30 related relate VBN cord-252725-e3pazjdi 149 31 symptoms symptom NNS cord-252725-e3pazjdi 149 32 . . . cord-252725-e3pazjdi 150 1 Naringenin Naringenin NNP cord-252725-e3pazjdi 150 2 ( ( -LRB- cord-252725-e3pazjdi 150 3 4′,5,7-trihydroxytlavanone 4′,5,7-trihydroxytlavanone CD cord-252725-e3pazjdi 150 4 ) ) -RRB- cord-252725-e3pazjdi 150 5 ( ( -LRB- cord-252725-e3pazjdi 150 6 Fig Fig NNP cord-252725-e3pazjdi 150 7 . . . cord-252725-e3pazjdi 150 8 9 9 CD cord-252725-e3pazjdi 150 9 ) ) -RRB- cord-252725-e3pazjdi 150 10 occurs occur VBZ cord-252725-e3pazjdi 150 11 naturally naturally RB cord-252725-e3pazjdi 150 12 in in IN cord-252725-e3pazjdi 150 13 a a DT cord-252725-e3pazjdi 150 14 variety variety NN cord-252725-e3pazjdi 150 15 of of IN cord-252725-e3pazjdi 150 16 citrus citrus JJ cord-252725-e3pazjdi 150 17 fruits fruit NNS cord-252725-e3pazjdi 150 18 , , , cord-252725-e3pazjdi 150 19 bergamot bergamot NN cord-252725-e3pazjdi 150 20 , , , cord-252725-e3pazjdi 150 21 tomatoes tomato NNS cord-252725-e3pazjdi 150 22 , , , cord-252725-e3pazjdi 150 23 tomato tomato NN cord-252725-e3pazjdi 150 24 food food NN cord-252725-e3pazjdi 150 25 products product NNS cord-252725-e3pazjdi 150 26 , , , cord-252725-e3pazjdi 150 27 grapefruit grapefruit NN cord-252725-e3pazjdi 150 28 , , , cord-252725-e3pazjdi 150 29 sour sour JJ cord-252725-e3pazjdi 150 30 orange orange NN cord-252725-e3pazjdi 150 31 , , , cord-252725-e3pazjdi 150 32 cherries cherry NNS cord-252725-e3pazjdi 150 33 , , , cord-252725-e3pazjdi 150 34 cocoa cocoa NN cord-252725-e3pazjdi 151 1 and and CC cord-252725-e3pazjdi 151 2 it -PRON- PRP cord-252725-e3pazjdi 151 3 is be VBZ cord-252725-e3pazjdi 151 4 may may MD cord-252725-e3pazjdi 151 5 be be VB cord-252725-e3pazjdi 151 6 found find VBN cord-252725-e3pazjdi 151 7 in in IN cord-252725-e3pazjdi 151 8 some some DT cord-252725-e3pazjdi 151 9 herbs herb NNS cord-252725-e3pazjdi 151 10 such such JJ cord-252725-e3pazjdi 151 11 as as IN cord-252725-e3pazjdi 151 12 oregano oregano NN cord-252725-e3pazjdi 151 13 and and CC cord-252725-e3pazjdi 151 14 water water NN cord-252725-e3pazjdi 151 15 mint mint NN cord-252725-e3pazjdi 151 16 . . . cord-252725-e3pazjdi 152 1 Naringenin Naringenin NNP cord-252725-e3pazjdi 152 2 has have VBZ cord-252725-e3pazjdi 152 3 many many JJ cord-252725-e3pazjdi 152 4 pharmacological pharmacological JJ cord-252725-e3pazjdi 152 5 effects effect NNS cord-252725-e3pazjdi 152 6 , , , cord-252725-e3pazjdi 152 7 including include VBG cord-252725-e3pazjdi 152 8 antidiabetic antidiabetic NNP cord-252725-e3pazjdi 152 9 , , , cord-252725-e3pazjdi 152 10 antiatherogenic antiatherogenic NNP cord-252725-e3pazjdi 152 11 , , , cord-252725-e3pazjdi 152 12 antidepressant antidepressant NN cord-252725-e3pazjdi 152 13 , , , cord-252725-e3pazjdi 152 14 immunomodulatory immunomodulatory NNP cord-252725-e3pazjdi 152 15 , , , cord-252725-e3pazjdi 152 16 antitumor antitumor NN cord-252725-e3pazjdi 152 17 , , , cord-252725-e3pazjdi 152 18 antiinflammatory antiinflammatory JJ cord-252725-e3pazjdi 152 19 , , , cord-252725-e3pazjdi 152 20 DNA DNA NNP cord-252725-e3pazjdi 152 21 protective protective NN cord-252725-e3pazjdi 152 22 , , , cord-252725-e3pazjdi 152 23 hypolipidaemic hypolipidaemic NNP cord-252725-e3pazjdi 152 24 , , , cord-252725-e3pazjdi 152 25 antioxidant antioxidant NN cord-252725-e3pazjdi 152 26 , , , cord-252725-e3pazjdi 152 27 antiasthma antiasthma NNP cord-252725-e3pazjdi 152 28 , , , cord-252725-e3pazjdi 152 29 antiviral antiviral JJ cord-252725-e3pazjdi 152 30 , , , cord-252725-e3pazjdi 152 31 antibacterial antibacterial JJ cord-252725-e3pazjdi 152 32 and and CC cord-252725-e3pazjdi 152 33 peroxisome peroxisome NN cord-252725-e3pazjdi 152 34 proliferator proliferator NN cord-252725-e3pazjdi 152 35 - - HYPH cord-252725-e3pazjdi 152 36 activated activate VBN cord-252725-e3pazjdi 152 37 receptors receptor NNS cord-252725-e3pazjdi 152 38 ( ( -LRB- cord-252725-e3pazjdi 152 39 PPARs ppar NNS cord-252725-e3pazjdi 152 40 ) ) -RRB- cord-252725-e3pazjdi 152 41 activator activator NN cord-252725-e3pazjdi 152 42 [ [ -LRB- cord-252725-e3pazjdi 152 43 56 56 CD cord-252725-e3pazjdi 152 44 , , , cord-252725-e3pazjdi 152 45 104 104 CD cord-252725-e3pazjdi 152 46 ] ] -RRB- cord-252725-e3pazjdi 152 47 . . . cord-252725-e3pazjdi 153 1 Naringenin Naringenin NNP cord-252725-e3pazjdi 153 2 blocks block VBZ cord-252725-e3pazjdi 153 3 MAPKs mapk NNS cord-252725-e3pazjdi 153 4 phosphorylation phosphorylation NN cord-252725-e3pazjdi 153 5 by by IN cord-252725-e3pazjdi 153 6 decreasing decrease VBG cord-252725-e3pazjdi 153 7 translocation translocation NN cord-252725-e3pazjdi 153 8 and and CC cord-252725-e3pazjdi 153 9 DNA dna NN cord-252725-e3pazjdi 153 10 binding binding NN cord-252725-e3pazjdi 153 11 of of IN cord-252725-e3pazjdi 153 12 NF nf NN cord-252725-e3pazjdi 153 13 - - HYPH cord-252725-e3pazjdi 153 14 κB κB NNP cord-252725-e3pazjdi 153 15 and and CC cord-252725-e3pazjdi 153 16 AP-1 AP-1 NNP cord-252725-e3pazjdi 153 17 , , , cord-252725-e3pazjdi 153 18 which which WDT cord-252725-e3pazjdi 153 19 restrain restrain VBP cord-252725-e3pazjdi 153 20 the the DT cord-252725-e3pazjdi 153 21 production production NN cord-252725-e3pazjdi 153 22 of of IN cord-252725-e3pazjdi 153 23 proinflammatory proinflammatory JJ cord-252725-e3pazjdi 153 24 cytokines cytokine NNS cord-252725-e3pazjdi 153 25 such such JJ cord-252725-e3pazjdi 153 26 as as IN cord-252725-e3pazjdi 153 27 IL-33 IL-33 NNP cord-252725-e3pazjdi 153 28 , , , cord-252725-e3pazjdi 153 29 TNF TNF NNP cord-252725-e3pazjdi 153 30 - - HYPH cord-252725-e3pazjdi 153 31 α α NNP cord-252725-e3pazjdi 153 32 , , , cord-252725-e3pazjdi 153 33 IL-1β IL-1β NNP cord-252725-e3pazjdi 153 34 , , , cord-252725-e3pazjdi 153 35 and and CC cord-252725-e3pazjdi 153 36 IL-6 IL-6 NNP cord-252725-e3pazjdi 153 37 [ [ -LRB- cord-252725-e3pazjdi 153 38 105 105 CD cord-252725-e3pazjdi 153 39 ] ] -RRB- cord-252725-e3pazjdi 153 40 . . . cord-252725-e3pazjdi 154 1 It -PRON- PRP cord-252725-e3pazjdi 154 2 has have VBZ cord-252725-e3pazjdi 154 3 been be VBN cord-252725-e3pazjdi 154 4 reported report VBN cord-252725-e3pazjdi 154 5 that that IN cord-252725-e3pazjdi 154 6 naringenin naringenin NNP cord-252725-e3pazjdi 154 7 suppressed suppress VBD cord-252725-e3pazjdi 154 8 respiratory respiratory JJ cord-252725-e3pazjdi 154 9 overexpression overexpression NN cord-252725-e3pazjdi 154 10 and and CC cord-252725-e3pazjdi 154 11 eosinophilic eosinophilic JJ cord-252725-e3pazjdi 154 12 airway airway NN cord-252725-e3pazjdi 154 13 inflammation inflammation NN cord-252725-e3pazjdi 154 14 in in IN cord-252725-e3pazjdi 154 15 asthma asthma NN cord-252725-e3pazjdi 154 16 and and CC cord-252725-e3pazjdi 154 17 thus thus RB cord-252725-e3pazjdi 154 18 , , , cord-252725-e3pazjdi 154 19 reduced reduce VBN cord-252725-e3pazjdi 154 20 acute acute JJ cord-252725-e3pazjdi 154 21 neutrophilic neutrophilic JJ cord-252725-e3pazjdi 154 22 airway airway NN cord-252725-e3pazjdi 154 23 inflammation inflammation NN cord-252725-e3pazjdi 154 24 by by IN cord-252725-e3pazjdi 154 25 blocking block VBG cord-252725-e3pazjdi 154 26 the the DT cord-252725-e3pazjdi 154 27 NF nf NN cord-252725-e3pazjdi 154 28 - - HYPH cord-252725-e3pazjdi 154 29 κB κB NNP cord-252725-e3pazjdi 154 30 pathway pathway NN cord-252725-e3pazjdi 154 31 [ [ -LRB- cord-252725-e3pazjdi 154 32 106 106 CD cord-252725-e3pazjdi 154 33 ] ] -RRB- cord-252725-e3pazjdi 154 34 . . . cord-252725-e3pazjdi 155 1 Naringenin Naringenin NNP cord-252725-e3pazjdi 155 2 has have VBZ cord-252725-e3pazjdi 155 3 been be VBN cord-252725-e3pazjdi 155 4 found find VBN cord-252725-e3pazjdi 155 5 to to TO cord-252725-e3pazjdi 155 6 impair impair VB cord-252725-e3pazjdi 155 7 replication replication NN cord-252725-e3pazjdi 155 8 of of IN cord-252725-e3pazjdi 155 9 several several JJ cord-252725-e3pazjdi 155 10 viruses virus NNS cord-252725-e3pazjdi 155 11 in in IN cord-252725-e3pazjdi 155 12 human human JJ cord-252725-e3pazjdi 155 13 cells cell NNS cord-252725-e3pazjdi 155 14 such such JJ cord-252725-e3pazjdi 155 15 as as IN cord-252725-e3pazjdi 155 16 dengue dengue NN cord-252725-e3pazjdi 155 17 , , , cord-252725-e3pazjdi 155 18 Zika Zika NNP cord-252725-e3pazjdi 155 19 and and CC cord-252725-e3pazjdi 155 20 Chikungunya chikungunya NN cord-252725-e3pazjdi 155 21 viruses virus NNS cord-252725-e3pazjdi 155 22 [ [ -LRB- cord-252725-e3pazjdi 155 23 107 107 CD cord-252725-e3pazjdi 155 24 ] ] -RRB- cord-252725-e3pazjdi 155 25 [ [ -LRB- cord-252725-e3pazjdi 155 26 108 108 CD cord-252725-e3pazjdi 155 27 ] ] -RRB- cord-252725-e3pazjdi 155 28 [ [ -LRB- cord-252725-e3pazjdi 155 29 109 109 CD cord-252725-e3pazjdi 155 30 ] ] -RRB- cord-252725-e3pazjdi 155 31 and and CC cord-252725-e3pazjdi 155 32 to to TO cord-252725-e3pazjdi 155 33 guarantee guarantee VB cord-252725-e3pazjdi 155 34 a a DT cord-252725-e3pazjdi 155 35 significant significant JJ cord-252725-e3pazjdi 155 36 protection protection NN cord-252725-e3pazjdi 155 37 against against IN cord-252725-e3pazjdi 155 38 LPSinduced LPSinduced NNP cord-252725-e3pazjdi 155 39 acute acute JJ cord-252725-e3pazjdi 155 40 lung lung NN cord-252725-e3pazjdi 155 41 injuries injury NNS cord-252725-e3pazjdi 155 42 through through IN cord-252725-e3pazjdi 155 43 its -PRON- PRP$ cord-252725-e3pazjdi 155 44 anti anti JJ cord-252725-e3pazjdi 155 45 - - JJ cord-252725-e3pazjdi 155 46 inflammatory inflammatory JJ cord-252725-e3pazjdi 155 47 , , , cord-252725-e3pazjdi 155 48 antioxidant antioxidant NN cord-252725-e3pazjdi 155 49 , , , cord-252725-e3pazjdi 155 50 antinitrosative antinitrosative JJ cord-252725-e3pazjdi 155 51 and and CC cord-252725-e3pazjdi 155 52 antiapoptotic antiapoptotic JJ cord-252725-e3pazjdi 155 53 effects effect NNS cord-252725-e3pazjdi 155 54 [ [ -LRB- cord-252725-e3pazjdi 155 55 110 110 CD cord-252725-e3pazjdi 155 56 , , , cord-252725-e3pazjdi 155 57 111 111 CD cord-252725-e3pazjdi 155 58 ] ] -RRB- cord-252725-e3pazjdi 155 59 . . . cord-252725-e3pazjdi 156 1 Due due IN cord-252725-e3pazjdi 156 2 to to IN cord-252725-e3pazjdi 156 3 its -PRON- PRP$ cord-252725-e3pazjdi 156 4 strong strong JJ cord-252725-e3pazjdi 156 5 anti anti JJ cord-252725-e3pazjdi 156 6 - - JJ cord-252725-e3pazjdi 156 7 inflammatory inflammatory JJ cord-252725-e3pazjdi 156 8 and and CC cord-252725-e3pazjdi 156 9 anti anti JJ cord-252725-e3pazjdi 156 10 - - JJ cord-252725-e3pazjdi 156 11 oxidant oxidant JJ cord-252725-e3pazjdi 156 12 effects effect NNS cord-252725-e3pazjdi 156 13 , , , cord-252725-e3pazjdi 156 14 narigenin narigenin NNP cord-252725-e3pazjdi 156 15 may may MD cord-252725-e3pazjdi 156 16 be be VB cord-252725-e3pazjdi 156 17 utilized utilize VBN cord-252725-e3pazjdi 156 18 against against IN cord-252725-e3pazjdi 156 19 pneumonia pneumonia NN cord-252725-e3pazjdi 156 20 companied companie VBN cord-252725-e3pazjdi 156 21 with with IN cord-252725-e3pazjdi 156 22 the the DT cord-252725-e3pazjdi 156 23 spread spread NN cord-252725-e3pazjdi 156 24 of of IN cord-252725-e3pazjdi 156 25 COVID-19 covid-19 NN cord-252725-e3pazjdi 156 26 . . . cord-252725-e3pazjdi 157 1 Gallic gallic JJ cord-252725-e3pazjdi 157 2 acid acid NN cord-252725-e3pazjdi 157 3 ( ( -LRB- cord-252725-e3pazjdi 157 4 3,4,5-trihydroxybenzoic 3,4,5-trihydroxybenzoic CD cord-252725-e3pazjdi 157 5 acid acid NN cord-252725-e3pazjdi 157 6 ) ) -RRB- cord-252725-e3pazjdi 158 1 ( ( -LRB- cord-252725-e3pazjdi 158 2 Fig Fig NNP cord-252725-e3pazjdi 158 3 . . . cord-252725-e3pazjdi 159 1 10 10 CD cord-252725-e3pazjdi 159 2 ) ) -RRB- cord-252725-e3pazjdi 159 3 , , , cord-252725-e3pazjdi 159 4 a a DT cord-252725-e3pazjdi 159 5 compound compound NN cord-252725-e3pazjdi 159 6 found find VBN cord-252725-e3pazjdi 159 7 in in IN cord-252725-e3pazjdi 159 8 several several JJ cord-252725-e3pazjdi 159 9 fruits fruit NNS cord-252725-e3pazjdi 159 10 and and CC cord-252725-e3pazjdi 159 11 medicinal medicinal JJ cord-252725-e3pazjdi 159 12 plants plant NNS cord-252725-e3pazjdi 159 13 including include VBG cord-252725-e3pazjdi 159 14 gallnuts gallnut NNS cord-252725-e3pazjdi 159 15 , , , cord-252725-e3pazjdi 159 16 grapes grape NNS cord-252725-e3pazjdi 159 17 , , , cord-252725-e3pazjdi 159 18 tea tea NN cord-252725-e3pazjdi 159 19 , , , cord-252725-e3pazjdi 159 20 hops hop NNS cord-252725-e3pazjdi 159 21 , , , cord-252725-e3pazjdi 159 22 oak oak NN cord-252725-e3pazjdi 159 23 bark bark NN cord-252725-e3pazjdi 159 24 , , , cord-252725-e3pazjdi 159 25 sumac sumac NN cord-252725-e3pazjdi 159 26 , , , cord-252725-e3pazjdi 159 27 black black JJ cord-252725-e3pazjdi 159 28 raspberry raspberry NN cord-252725-e3pazjdi 159 29 , , , cord-252725-e3pazjdi 159 30 witch witch NN cord-252725-e3pazjdi 159 31 hazel hazel NN cord-252725-e3pazjdi 159 32 and and CC cord-252725-e3pazjdi 159 33 mostly mostly RB cord-252725-e3pazjdi 159 34 in in IN cord-252725-e3pazjdi 159 35 certain certain JJ cord-252725-e3pazjdi 159 36 red red JJ cord-252725-e3pazjdi 159 37 fruits fruit NNS cord-252725-e3pazjdi 159 38 , , , cord-252725-e3pazjdi 159 39 black black JJ cord-252725-e3pazjdi 159 40 radish radish NN cord-252725-e3pazjdi 159 41 , , , cord-252725-e3pazjdi 159 42 and and CC cord-252725-e3pazjdi 159 43 onions onion NNS cord-252725-e3pazjdi 159 44 is be VBZ cord-252725-e3pazjdi 159 45 a a DT cord-252725-e3pazjdi 159 46 phenolic phenolic JJ cord-252725-e3pazjdi 159 47 acid acid NN cord-252725-e3pazjdi 159 48 that that WDT cord-252725-e3pazjdi 159 49 comprises comprise VBZ cord-252725-e3pazjdi 159 50 several several JJ cord-252725-e3pazjdi 159 51 valuable valuable JJ cord-252725-e3pazjdi 159 52 pharmaceutical pharmaceutical JJ cord-252725-e3pazjdi 159 53 properties property NNS cord-252725-e3pazjdi 159 54 including include VBG cord-252725-e3pazjdi 159 55 antioxidant antioxidant JJ cord-252725-e3pazjdi 159 56 , , , cord-252725-e3pazjdi 159 57 anti anti JJ cord-252725-e3pazjdi 159 58 - - JJ cord-252725-e3pazjdi 159 59 inflammatory inflammatory JJ cord-252725-e3pazjdi 159 60 , , , cord-252725-e3pazjdi 159 61 antineoplastic antineoplastic JJ cord-252725-e3pazjdi 159 62 , , , cord-252725-e3pazjdi 159 63 anti anti JJ cord-252725-e3pazjdi 159 64 - - JJ cord-252725-e3pazjdi 159 65 cancer cancer JJ cord-252725-e3pazjdi 159 66 , , , cord-252725-e3pazjdi 159 67 gastrointestinal gastrointestinal JJ cord-252725-e3pazjdi 159 68 and and CC cord-252725-e3pazjdi 159 69 cardiovascular cardiovascular JJ cord-252725-e3pazjdi 159 70 protective protective JJ cord-252725-e3pazjdi 159 71 , , , cord-252725-e3pazjdi 159 72 antiviral antiviral JJ cord-252725-e3pazjdi 159 73 , , , cord-252725-e3pazjdi 159 74 antibiotic antibiotic JJ cord-252725-e3pazjdi 159 75 and and CC cord-252725-e3pazjdi 159 76 antimicrobial antimicrobial JJ cord-252725-e3pazjdi 159 77 . . . cord-252725-e3pazjdi 160 1 The the DT cord-252725-e3pazjdi 160 2 strong strong JJ cord-252725-e3pazjdi 160 3 anti anti JJ cord-252725-e3pazjdi 160 4 - - JJ cord-252725-e3pazjdi 160 5 oxidant oxidant JJ cord-252725-e3pazjdi 160 6 capacity capacity NN cord-252725-e3pazjdi 160 7 of of IN cord-252725-e3pazjdi 160 8 gallic gallic JJ cord-252725-e3pazjdi 160 9 acid acid NN cord-252725-e3pazjdi 160 10 grants grant NNS cord-252725-e3pazjdi 160 11 it -PRON- PRP cord-252725-e3pazjdi 160 12 an an DT cord-252725-e3pazjdi 160 13 important important JJ cord-252725-e3pazjdi 160 14 role role NN cord-252725-e3pazjdi 160 15 in in IN cord-252725-e3pazjdi 160 16 absorbing absorb VBG cord-252725-e3pazjdi 160 17 and and CC cord-252725-e3pazjdi 160 18 neutralizing neutralize VBG cord-252725-e3pazjdi 160 19 free free JJ cord-252725-e3pazjdi 160 20 radicals radical NNS cord-252725-e3pazjdi 160 21 , , , cord-252725-e3pazjdi 160 22 with with IN cord-252725-e3pazjdi 160 23 even even RB cord-252725-e3pazjdi 160 24 better well JJR cord-252725-e3pazjdi 160 25 results result NNS cord-252725-e3pazjdi 160 26 than than IN cord-252725-e3pazjdi 160 27 some some DT cord-252725-e3pazjdi 160 28 vitamins vitamin NNS cord-252725-e3pazjdi 160 29 [ [ -LRB- cord-252725-e3pazjdi 160 30 112 112 CD cord-252725-e3pazjdi 160 31 , , , cord-252725-e3pazjdi 160 32 113 113 CD cord-252725-e3pazjdi 160 33 ] ] -RRB- cord-252725-e3pazjdi 160 34 . . . cord-252725-e3pazjdi 161 1 It -PRON- PRP cord-252725-e3pazjdi 161 2 was be VBD cord-252725-e3pazjdi 161 3 reported report VBN cord-252725-e3pazjdi 161 4 that that IN cord-252725-e3pazjdi 161 5 , , , cord-252725-e3pazjdi 161 6 gallic gallic JJ cord-252725-e3pazjdi 161 7 acid acid NN cord-252725-e3pazjdi 161 8 has have VBZ cord-252725-e3pazjdi 161 9 several several JJ cord-252725-e3pazjdi 161 10 antiviral antiviral JJ cord-252725-e3pazjdi 161 11 activities activity NNS cord-252725-e3pazjdi 161 12 such such JJ cord-252725-e3pazjdi 161 13 as as IN cord-252725-e3pazjdi 161 14 anti anti JJ cord-252725-e3pazjdi 161 15 - - JJ cord-252725-e3pazjdi 161 16 enterovirus enterovirus JJ cord-252725-e3pazjdi 161 17 71 71 CD cord-252725-e3pazjdi 161 18 ( ( -LRB- cord-252725-e3pazjdi 161 19 EV71 EV71 NNP cord-252725-e3pazjdi 161 20 ) ) -RRB- cord-252725-e3pazjdi 161 21 , , , cord-252725-e3pazjdi 161 22 anti anti JJ cord-252725-e3pazjdi 161 23 - - JJ cord-252725-e3pazjdi 161 24 herpes herpes JJ cord-252725-e3pazjdi 161 25 simplex simplex NN cord-252725-e3pazjdi 161 26 virus virus NN cord-252725-e3pazjdi 161 27 ( ( -LRB- cord-252725-e3pazjdi 161 28 HSV)-2 hsv)-2 NN cord-252725-e3pazjdi 161 29 and and CC cord-252725-e3pazjdi 161 30 anti anti JJ cord-252725-e3pazjdi 161 31 - - JJ cord-252725-e3pazjdi 161 32 human human JJ cord-252725-e3pazjdi 161 33 immunodeficiency immunodeficiency NN cord-252725-e3pazjdi 161 34 virus virus NN cord-252725-e3pazjdi 161 35 activity activity NN cord-252725-e3pazjdi 161 36 and and CC cord-252725-e3pazjdi 161 37 anti anti JJ cord-252725-e3pazjdi 161 38 - - JJ cord-252725-e3pazjdi 161 39 hepatitis hepatitis JJ cord-252725-e3pazjdi 161 40 C c NN cord-252725-e3pazjdi 161 41 ( ( -LRB- cord-252725-e3pazjdi 161 42 HCV HCV NNP cord-252725-e3pazjdi 161 43 ) ) -RRB- cord-252725-e3pazjdi 161 44 [ [ -LRB- cord-252725-e3pazjdi 161 45 114 114 CD cord-252725-e3pazjdi 161 46 , , , cord-252725-e3pazjdi 161 47 115 115 CD cord-252725-e3pazjdi 161 48 ] ] -RRB- cord-252725-e3pazjdi 161 49 . . . cord-252725-e3pazjdi 162 1 Gallic gallic JJ cord-252725-e3pazjdi 162 2 acid acid NN cord-252725-e3pazjdi 162 3 of of IN cord-252725-e3pazjdi 162 4 black black JJ cord-252725-e3pazjdi 162 5 raspberry raspberry NN cord-252725-e3pazjdi 162 6 seeds seed NNS cord-252725-e3pazjdi 162 7 was be VBD cord-252725-e3pazjdi 162 8 demonstrated demonstrate VBN cord-252725-e3pazjdi 162 9 in in IN cord-252725-e3pazjdi 162 10 vitro vitro FW cord-252725-e3pazjdi 162 11 to to TO cord-252725-e3pazjdi 162 12 have have VB cord-252725-e3pazjdi 162 13 an an DT cord-252725-e3pazjdi 162 14 antiviral antiviral JJ cord-252725-e3pazjdi 162 15 activity activity NN cord-252725-e3pazjdi 162 16 against against IN cord-252725-e3pazjdi 162 17 influenza influenza NN cord-252725-e3pazjdi 162 18 A a NN cord-252725-e3pazjdi 162 19 and and CC cord-252725-e3pazjdi 162 20 B b NN cord-252725-e3pazjdi 162 21 type type NN cord-252725-e3pazjdi 162 22 viruses virus NNS cord-252725-e3pazjdi 162 23 which which WDT cord-252725-e3pazjdi 162 24 suggested suggest VBD cord-252725-e3pazjdi 162 25 a a DT cord-252725-e3pazjdi 162 26 promising promising JJ cord-252725-e3pazjdi 162 27 role role NN cord-252725-e3pazjdi 162 28 in in IN cord-252725-e3pazjdi 162 29 targeting target VBG cord-252725-e3pazjdi 162 30 virus virus NN cord-252725-e3pazjdi 162 31 particles particle NNS cord-252725-e3pazjdi 162 32 [ [ -LRB- cord-252725-e3pazjdi 162 33 116 116 CD cord-252725-e3pazjdi 162 34 ] ] -RRB- cord-252725-e3pazjdi 162 35 . . . cord-252725-e3pazjdi 163 1 Similarly similarly RB cord-252725-e3pazjdi 163 2 , , , cord-252725-e3pazjdi 163 3 anti anti JJ cord-252725-e3pazjdi 163 4 - - JJ cord-252725-e3pazjdi 163 5 pandemic pandemic JJ cord-252725-e3pazjdi 163 6 potential potential JJ cord-252725-e3pazjdi 163 7 role role NN cord-252725-e3pazjdi 163 8 of of IN cord-252725-e3pazjdi 163 9 gallic gallic JJ cord-252725-e3pazjdi 163 10 acid acid NN cord-252725-e3pazjdi 163 11 against against IN cord-252725-e3pazjdi 163 12 influenza influenza NN cord-252725-e3pazjdi 163 13 A a NN cord-252725-e3pazjdi 163 14 ( ( -LRB- cord-252725-e3pazjdi 163 15 H1N1 H1N1 NNP cord-252725-e3pazjdi 163 16 ) ) -RRB- cord-252725-e3pazjdi 163 17 virus virus NN cord-252725-e3pazjdi 163 18 was be VBD cord-252725-e3pazjdi 163 19 demonstrated demonstrate VBN cord-252725-e3pazjdi 163 20 through through IN cord-252725-e3pazjdi 163 21 the the DT cord-252725-e3pazjdi 163 22 down down JJ cord-252725-e3pazjdi 163 23 - - HYPH cord-252725-e3pazjdi 163 24 regulation regulation NN cord-252725-e3pazjdi 163 25 of of IN cord-252725-e3pazjdi 163 26 adhesion adhesion NN cord-252725-e3pazjdi 163 27 molecules molecule NNS cord-252725-e3pazjdi 163 28 and and CC cord-252725-e3pazjdi 163 29 chemokine chemokine NN cord-252725-e3pazjdi 163 30 to to TO cord-252725-e3pazjdi 163 31 prevent prevent VB cord-252725-e3pazjdi 163 32 viral viral JJ cord-252725-e3pazjdi 163 33 attachment attachment NN cord-252725-e3pazjdi 163 34 and and CC cord-252725-e3pazjdi 163 35 inhibition inhibition NN cord-252725-e3pazjdi 163 36 of of IN cord-252725-e3pazjdi 163 37 the the DT cord-252725-e3pazjdi 163 38 virus virus NN cord-252725-e3pazjdi 164 1 mRNA mrna NN cord-252725-e3pazjdi 164 2 replication replication NN cord-252725-e3pazjdi 164 3 [ [ -LRB- cord-252725-e3pazjdi 164 4 117 117 CD cord-252725-e3pazjdi 164 5 ] ] -RRB- cord-252725-e3pazjdi 164 6 . . . cord-252725-e3pazjdi 165 1 A a DT cord-252725-e3pazjdi 165 2 study study NN cord-252725-e3pazjdi 165 3 has have VBZ cord-252725-e3pazjdi 165 4 reported report VBN cord-252725-e3pazjdi 165 5 that that IN cord-252725-e3pazjdi 165 6 inhibition inhibition NN cord-252725-e3pazjdi 165 7 of of IN cord-252725-e3pazjdi 165 8 human human JJ cord-252725-e3pazjdi 165 9 rhinoviruses rhinovirus NNS cord-252725-e3pazjdi 165 10 ( ( -LRB- cord-252725-e3pazjdi 165 11 HRV HRV NNP cord-252725-e3pazjdi 165 12 ) ) -RRB- cord-252725-e3pazjdi 165 13 production production NN cord-252725-e3pazjdi 165 14 by by IN cord-252725-e3pazjdi 165 15 gallic gallic JJ cord-252725-e3pazjdi 165 16 acid acid NN cord-252725-e3pazjdi 165 17 is be VBZ cord-252725-e3pazjdi 165 18 mainly mainly RB cord-252725-e3pazjdi 165 19 due due JJ cord-252725-e3pazjdi 165 20 to to IN cord-252725-e3pazjdi 165 21 its -PRON- PRP$ cord-252725-e3pazjdi 165 22 general general JJ cord-252725-e3pazjdi 165 23 role role NN cord-252725-e3pazjdi 165 24 as as IN cord-252725-e3pazjdi 165 25 an an DT cord-252725-e3pazjdi 165 26 antioxidant antioxidant NN cord-252725-e3pazjdi 165 27 and and CC cord-252725-e3pazjdi 165 28 the the DT cord-252725-e3pazjdi 165 29 mode mode NN cord-252725-e3pazjdi 165 30 of of IN cord-252725-e3pazjdi 165 31 action action NN cord-252725-e3pazjdi 165 32 derived derive VBN cord-252725-e3pazjdi 165 33 from from IN cord-252725-e3pazjdi 165 34 the the DT cord-252725-e3pazjdi 165 35 inhibition inhibition NN cord-252725-e3pazjdi 165 36 of of IN cord-252725-e3pazjdi 165 37 virus virus NN cord-252725-e3pazjdi 165 38 absorption absorption NN cord-252725-e3pazjdi 165 39 [ [ -LRB- cord-252725-e3pazjdi 165 40 118 118 CD cord-252725-e3pazjdi 165 41 ] ] -RRB- cord-252725-e3pazjdi 165 42 . . . cord-252725-e3pazjdi 166 1 Moreover moreover RB cord-252725-e3pazjdi 166 2 , , , cord-252725-e3pazjdi 166 3 gallic gallic JJ cord-252725-e3pazjdi 166 4 acid acid NN cord-252725-e3pazjdi 166 5 along along IN cord-252725-e3pazjdi 166 6 with with IN cord-252725-e3pazjdi 166 7 other other JJ cord-252725-e3pazjdi 166 8 related related JJ cord-252725-e3pazjdi 166 9 phenolic phenolic JJ cord-252725-e3pazjdi 166 10 acids acid NNS cord-252725-e3pazjdi 166 11 ( ( -LRB- cord-252725-e3pazjdi 167 1 caffeic caffeic NNP cord-252725-e3pazjdi 167 2 acid acid NN cord-252725-e3pazjdi 167 3 , , , cord-252725-e3pazjdi 167 4 chlorogenic chlorogenic JJ cord-252725-e3pazjdi 167 5 acid acid NN cord-252725-e3pazjdi 167 6 ) ) -RRB- cord-252725-e3pazjdi 167 7 was be VBD cord-252725-e3pazjdi 167 8 found find VBN cord-252725-e3pazjdi 167 9 to to TO cord-252725-e3pazjdi 167 10 exert exert VB cord-252725-e3pazjdi 167 11 sustainable sustainable JJ cord-252725-e3pazjdi 167 12 anti anti JJ cord-252725-e3pazjdi 167 13 - - JJ cord-252725-e3pazjdi 167 14 viral viral JJ cord-252725-e3pazjdi 167 15 activity activity NN cord-252725-e3pazjdi 167 16 against against IN cord-252725-e3pazjdi 167 17 human human JJ cord-252725-e3pazjdi 167 18 coronavirus coronavirus NN cord-252725-e3pazjdi 168 1 NL63 NL63 NNP cord-252725-e3pazjdi 169 1 ( ( -LRB- cord-252725-e3pazjdi 169 2 HCoV HCoV NNP cord-252725-e3pazjdi 169 3 - - HYPH cord-252725-e3pazjdi 169 4 NL63 NL63 NNP cord-252725-e3pazjdi 169 5 ) ) -RRB- cord-252725-e3pazjdi 169 6 , , , cord-252725-e3pazjdi 169 7 one one CD cord-252725-e3pazjdi 169 8 of of IN cord-252725-e3pazjdi 169 9 the the DT cord-252725-e3pazjdi 169 10 main main JJ cord-252725-e3pazjdi 169 11 circulating circulate VBG cord-252725-e3pazjdi 169 12 coronaviruses coronaviruse NNS cord-252725-e3pazjdi 169 13 worldwide worldwide RB cord-252725-e3pazjdi 169 14 that that WDT cord-252725-e3pazjdi 169 15 causes cause VBZ cord-252725-e3pazjdi 169 16 respiratory respiratory JJ cord-252725-e3pazjdi 169 17 tract tract NN cord-252725-e3pazjdi 169 18 diseases disease NNS cord-252725-e3pazjdi 169 19 like like IN cord-252725-e3pazjdi 169 20 runny runny JJ cord-252725-e3pazjdi 169 21 nose nose NN cord-252725-e3pazjdi 169 22 , , , cord-252725-e3pazjdi 169 23 cough cough NN cord-252725-e3pazjdi 169 24 , , , cord-252725-e3pazjdi 169 25 bronchiolitis bronchiolitis NN cord-252725-e3pazjdi 169 26 and and CC cord-252725-e3pazjdi 169 27 pneumonia pneumonia NN cord-252725-e3pazjdi 169 28 [ [ -LRB- cord-252725-e3pazjdi 169 29 119 119 CD cord-252725-e3pazjdi 169 30 ] ] -RRB- cord-252725-e3pazjdi 169 31 . . . cord-252725-e3pazjdi 170 1 Based base VBN cord-252725-e3pazjdi 170 2 on on IN cord-252725-e3pazjdi 170 3 the the DT cord-252725-e3pazjdi 170 4 above above JJ cord-252725-e3pazjdi 170 5 information information NN cord-252725-e3pazjdi 170 6 , , , cord-252725-e3pazjdi 170 7 gallic gallic JJ cord-252725-e3pazjdi 170 8 acid acid NN cord-252725-e3pazjdi 170 9 could could MD cord-252725-e3pazjdi 170 10 be be VB cord-252725-e3pazjdi 170 11 proposed propose VBN cord-252725-e3pazjdi 170 12 as as IN cord-252725-e3pazjdi 170 13 an an DT cord-252725-e3pazjdi 170 14 alternative alternative JJ cord-252725-e3pazjdi 170 15 treatment treatment NN cord-252725-e3pazjdi 170 16 for for IN cord-252725-e3pazjdi 170 17 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 170 18 and and CC cord-252725-e3pazjdi 170 19 its -PRON- PRP$ cord-252725-e3pazjdi 170 20 related related JJ cord-252725-e3pazjdi 170 21 symptoms symptom NNS cord-252725-e3pazjdi 170 22 . . . cord-252725-e3pazjdi 171 1 Caffeic Caffeic NNP cord-252725-e3pazjdi 171 2 acid acid NN cord-252725-e3pazjdi 171 3 ( ( -LRB- cord-252725-e3pazjdi 171 4 3,4-dihydroxycinnamicacid 3,4-dihydroxycinnamicacid CD cord-252725-e3pazjdi 171 5 ) ) -RRB- cord-252725-e3pazjdi 172 1 ( ( -LRB- cord-252725-e3pazjdi 172 2 Fig Fig NNP cord-252725-e3pazjdi 172 3 . . . cord-252725-e3pazjdi 173 1 11 11 LS cord-252725-e3pazjdi 173 2 ) ) -RRB- cord-252725-e3pazjdi 173 3 is be VBZ cord-252725-e3pazjdi 173 4 one one CD cord-252725-e3pazjdi 173 5 of of IN cord-252725-e3pazjdi 173 6 the the DT cord-252725-e3pazjdi 173 7 most most RBS cord-252725-e3pazjdi 173 8 common common JJ cord-252725-e3pazjdi 173 9 phenolic phenolic JJ cord-252725-e3pazjdi 173 10 acids acid NNS cord-252725-e3pazjdi 173 11 , , , cord-252725-e3pazjdi 173 12 which which WDT cord-252725-e3pazjdi 173 13 occurs occur VBZ cord-252725-e3pazjdi 173 14 frequently frequently RB cord-252725-e3pazjdi 173 15 in in IN cord-252725-e3pazjdi 173 16 fruits fruit NNS cord-252725-e3pazjdi 173 17 , , , cord-252725-e3pazjdi 173 18 grains grain NNS cord-252725-e3pazjdi 173 19 , , , cord-252725-e3pazjdi 173 20 medicinal medicinal JJ cord-252725-e3pazjdi 173 21 herbs herb NNS cord-252725-e3pazjdi 173 22 and and CC cord-252725-e3pazjdi 173 23 dietary dietary JJ cord-252725-e3pazjdi 173 24 supplements supplement NNS cord-252725-e3pazjdi 173 25 . . . cord-252725-e3pazjdi 174 1 [ [ -LRB- cord-252725-e3pazjdi 174 2 120 120 CD cord-252725-e3pazjdi 174 3 , , , cord-252725-e3pazjdi 174 4 121 121 CD cord-252725-e3pazjdi 174 5 ] ] -RRB- cord-252725-e3pazjdi 174 6 . . . cord-252725-e3pazjdi 175 1 In in IN cord-252725-e3pazjdi 175 2 vitro vitro FW cord-252725-e3pazjdi 175 3 and and CC cord-252725-e3pazjdi 175 4 in in IN cord-252725-e3pazjdi 175 5 vivo vivo NN cord-252725-e3pazjdi 175 6 experiments experiment NNS cord-252725-e3pazjdi 175 7 showed show VBD cord-252725-e3pazjdi 175 8 that that IN cord-252725-e3pazjdi 175 9 caffeic caffeic NNS cord-252725-e3pazjdi 175 10 acid acid NN cord-252725-e3pazjdi 175 11 and and CC cord-252725-e3pazjdi 175 12 its -PRON- PRP$ cord-252725-e3pazjdi 175 13 derivatives derivative NNS cord-252725-e3pazjdi 175 14 such such JJ cord-252725-e3pazjdi 175 15 as as IN cord-252725-e3pazjdi 175 16 caffeic caffeic NN cord-252725-e3pazjdi 175 17 acid acid NN cord-252725-e3pazjdi 175 18 phenethyl phenethyl NN cord-252725-e3pazjdi 175 19 ester ester NN cord-252725-e3pazjdi 175 20 have have VBP cord-252725-e3pazjdi 175 21 numerous numerous JJ cord-252725-e3pazjdi 175 22 physiological physiological JJ cord-252725-e3pazjdi 175 23 activities activity NNS cord-252725-e3pazjdi 175 24 including include VBG cord-252725-e3pazjdi 175 25 antibacterial antibacterial JJ cord-252725-e3pazjdi 175 26 , , , cord-252725-e3pazjdi 175 27 antiviral antiviral JJ cord-252725-e3pazjdi 175 28 , , , cord-252725-e3pazjdi 175 29 antioxidant antioxidant JJ cord-252725-e3pazjdi 175 30 , , , cord-252725-e3pazjdi 175 31 anti anti JJ cord-252725-e3pazjdi 175 32 - - JJ cord-252725-e3pazjdi 175 33 inflammatory inflammatory JJ cord-252725-e3pazjdi 175 34 , , , cord-252725-e3pazjdi 175 35 anti anti JJ cord-252725-e3pazjdi 175 36 - - JJ cord-252725-e3pazjdi 175 37 atherosclerotic atherosclerotic JJ cord-252725-e3pazjdi 175 38 , , , cord-252725-e3pazjdi 175 39 immunostimulatory immunostimulatory NN cord-252725-e3pazjdi 175 40 , , , cord-252725-e3pazjdi 175 41 antidiabetic antidiabetic NNP cord-252725-e3pazjdi 175 42 , , , cord-252725-e3pazjdi 175 43 cardioprotective cardioprotective JJ cord-252725-e3pazjdi 175 44 , , , cord-252725-e3pazjdi 175 45 antiproliferative antiproliferative JJ cord-252725-e3pazjdi 175 46 , , , cord-252725-e3pazjdi 175 47 hepatoprotective hepatoprotective JJ cord-252725-e3pazjdi 175 48 , , , cord-252725-e3pazjdi 175 49 anticancer anticancer JJ cord-252725-e3pazjdi 175 50 , , , cord-252725-e3pazjdi 175 51 and and CC cord-252725-e3pazjdi 175 52 antihepatocellular antihepatocellular JJ cord-252725-e3pazjdi 175 53 carcinoma carcinoma NN cord-252725-e3pazjdi 175 54 activity activity NN cord-252725-e3pazjdi 175 55 [ [ -LRB- cord-252725-e3pazjdi 175 56 121 121 CD cord-252725-e3pazjdi 175 57 , , , cord-252725-e3pazjdi 175 58 122 122 CD cord-252725-e3pazjdi 175 59 ] ] -RRB- cord-252725-e3pazjdi 175 60 . . . cord-252725-e3pazjdi 176 1 Caffeic Caffeic NNP cord-252725-e3pazjdi 176 2 acid acid NN cord-252725-e3pazjdi 176 3 of of IN cord-252725-e3pazjdi 176 4 Sambucus Sambucus NNP cord-252725-e3pazjdi 176 5 Formosana Formosana NNP cord-252725-e3pazjdi 176 6 Nakai Nakai NNP cord-252725-e3pazjdi 177 1 ethanol ethanol NN cord-252725-e3pazjdi 177 2 extract extract NN cord-252725-e3pazjdi 177 3 significantly significantly RB cord-252725-e3pazjdi 177 4 repressed repress VBD cord-252725-e3pazjdi 177 5 the the DT cord-252725-e3pazjdi 177 6 replication replication NN cord-252725-e3pazjdi 177 7 of of IN cord-252725-e3pazjdi 177 8 human human JJ cord-252725-e3pazjdi 177 9 coronavirus coronavirus NN cord-252725-e3pazjdi 178 1 NL63 NL63 NNP cord-252725-e3pazjdi 179 1 ( ( -LRB- cord-252725-e3pazjdi 179 2 HCoV HCoV NNP cord-252725-e3pazjdi 179 3 - - HYPH cord-252725-e3pazjdi 179 4 NL63 NL63 NNP cord-252725-e3pazjdi 179 5 ) ) -RRB- cord-252725-e3pazjdi 179 6 that that WDT cord-252725-e3pazjdi 179 7 causes cause VBZ cord-252725-e3pazjdi 179 8 upper upper JJ cord-252725-e3pazjdi 179 9 respiratory respiratory JJ cord-252725-e3pazjdi 179 10 tract tract NN cord-252725-e3pazjdi 179 11 illnesses illness NNS cord-252725-e3pazjdi 179 12 , , , cord-252725-e3pazjdi 179 13 in in IN cord-252725-e3pazjdi 179 14 a a DT cord-252725-e3pazjdi 179 15 cell cell NN cord-252725-e3pazjdi 179 16 - - HYPH cord-252725-e3pazjdi 179 17 type type NN cord-252725-e3pazjdi 179 18 independent independent JJ cord-252725-e3pazjdi 179 19 manner manner NN cord-252725-e3pazjdi 179 20 , , , cord-252725-e3pazjdi 179 21 and and CC cord-252725-e3pazjdi 179 22 blocked block VBD cord-252725-e3pazjdi 179 23 virus virus NN cord-252725-e3pazjdi 179 24 attachment attachment NN cord-252725-e3pazjdi 179 25 . . . cord-252725-e3pazjdi 180 1 The the DT cord-252725-e3pazjdi 180 2 study study NN cord-252725-e3pazjdi 180 3 proposed propose VBD cord-252725-e3pazjdi 180 4 that that IN cord-252725-e3pazjdi 180 5 caffeic caffeic NN cord-252725-e3pazjdi 180 6 acid acid NN cord-252725-e3pazjdi 180 7 could could MD cord-252725-e3pazjdi 180 8 be be VB cord-252725-e3pazjdi 180 9 the the DT cord-252725-e3pazjdi 180 10 vital vital JJ cord-252725-e3pazjdi 180 11 component component NN cord-252725-e3pazjdi 180 12 with with IN cord-252725-e3pazjdi 180 13 anti anti JJ cord-252725-e3pazjdi 180 14 - - JJ cord-252725-e3pazjdi 180 15 HCoV hcov JJ cord-252725-e3pazjdi 180 16 - - HYPH cord-252725-e3pazjdi 180 17 NL63 NL63 NNP cord-252725-e3pazjdi 180 18 activity activity NN cord-252725-e3pazjdi 180 19 [ [ -LRB- cord-252725-e3pazjdi 180 20 119 119 CD cord-252725-e3pazjdi 180 21 ] ] -RRB- cord-252725-e3pazjdi 180 22 . . . cord-252725-e3pazjdi 181 1 In in IN cord-252725-e3pazjdi 181 2 vitro vitro FW cord-252725-e3pazjdi 181 3 caffeic caffeic NN cord-252725-e3pazjdi 181 4 acid acid NN cord-252725-e3pazjdi 181 5 demonstrated demonstrate VBD cord-252725-e3pazjdi 181 6 an an DT cord-252725-e3pazjdi 181 7 antiviral antiviral JJ cord-252725-e3pazjdi 181 8 activity activity NN cord-252725-e3pazjdi 181 9 by by IN cord-252725-e3pazjdi 181 10 acting act VBG cord-252725-e3pazjdi 181 11 on on IN cord-252725-e3pazjdi 181 12 severe severe JJ cord-252725-e3pazjdi 181 13 fever fever NN cord-252725-e3pazjdi 181 14 with with IN cord-252725-e3pazjdi 181 15 thrombocytopenia thrombocytopenia NN cord-252725-e3pazjdi 181 16 syndrome syndrome NN cord-252725-e3pazjdi 181 17 ( ( -LRB- cord-252725-e3pazjdi 181 18 SFTS SFTS NNP cord-252725-e3pazjdi 181 19 ) ) -RRB- cord-252725-e3pazjdi 181 20 virus virus NN cord-252725-e3pazjdi 181 21 , , , cord-252725-e3pazjdi 181 22 which which WDT cord-252725-e3pazjdi 181 23 causes cause VBZ cord-252725-e3pazjdi 181 24 tick tick NN cord-252725-e3pazjdi 181 25 - - HYPH cord-252725-e3pazjdi 181 26 borne bear VBN cord-252725-e3pazjdi 181 27 hemorrhagic hemorrhagic JJ cord-252725-e3pazjdi 181 28 fever fever NN cord-252725-e3pazjdi 181 29 in in IN cord-252725-e3pazjdi 181 30 East East NNP cord-252725-e3pazjdi 181 31 Asia Asia NNP cord-252725-e3pazjdi 181 32 , , , cord-252725-e3pazjdi 181 33 and and CC cord-252725-e3pazjdi 181 34 hinders hinder VBZ cord-252725-e3pazjdi 181 35 viral viral JJ cord-252725-e3pazjdi 181 36 infection infection NN cord-252725-e3pazjdi 181 37 and and CC cord-252725-e3pazjdi 181 38 spread spread VBN cord-252725-e3pazjdi 181 39 by by IN cord-252725-e3pazjdi 181 40 inhibiting inhibit VBG cord-252725-e3pazjdi 181 41 the the DT cord-252725-e3pazjdi 181 42 binding binding NN cord-252725-e3pazjdi 181 43 of of IN cord-252725-e3pazjdi 181 44 SFTSV SFTSV NNP cord-252725-e3pazjdi 181 45 to to IN cord-252725-e3pazjdi 181 46 the the DT cord-252725-e3pazjdi 181 47 cells cell NNS cord-252725-e3pazjdi 181 48 [ [ -LRB- cord-252725-e3pazjdi 181 49 123 123 CD cord-252725-e3pazjdi 181 50 ] ] -RRB- cord-252725-e3pazjdi 181 51 . . . cord-252725-e3pazjdi 182 1 Conjugation conjugation NN cord-252725-e3pazjdi 182 2 of of IN cord-252725-e3pazjdi 182 3 peramivir peramivir NNS cord-252725-e3pazjdi 182 4 , , , cord-252725-e3pazjdi 182 5 an an DT cord-252725-e3pazjdi 182 6 influenza influenza NN cord-252725-e3pazjdi 182 7 inhibitor inhibitor NN cord-252725-e3pazjdi 182 8 with with IN cord-252725-e3pazjdi 182 9 caffeic caffeic NN cord-252725-e3pazjdi 182 10 acid acid NN cord-252725-e3pazjdi 182 11 has have VBZ cord-252725-e3pazjdi 182 12 showed show VBN cord-252725-e3pazjdi 182 13 a a DT cord-252725-e3pazjdi 182 14 better well JJR cord-252725-e3pazjdi 182 15 drug drug NN cord-252725-e3pazjdi 182 16 efficacy efficacy NN cord-252725-e3pazjdi 182 17 against against IN cord-252725-e3pazjdi 182 18 influenza influenza NN cord-252725-e3pazjdi 182 19 and and CC cord-252725-e3pazjdi 182 20 was be VBD cord-252725-e3pazjdi 182 21 found find VBN cord-252725-e3pazjdi 182 22 to to TO cord-252725-e3pazjdi 182 23 inhibit inhibit VB cord-252725-e3pazjdi 182 24 influenza influenza NN cord-252725-e3pazjdi 182 25 neuraminidase neuraminidase NN cord-252725-e3pazjdi 182 26 [ [ -LRB- cord-252725-e3pazjdi 182 27 124 124 CD cord-252725-e3pazjdi 182 28 , , , cord-252725-e3pazjdi 182 29 125 125 CD cord-252725-e3pazjdi 182 30 ] ] -RRB- cord-252725-e3pazjdi 182 31 . . . cord-252725-e3pazjdi 183 1 Moreover moreover RB cord-252725-e3pazjdi 183 2 , , , cord-252725-e3pazjdi 183 3 a a DT cord-252725-e3pazjdi 183 4 study study NN cord-252725-e3pazjdi 183 5 has have VBZ cord-252725-e3pazjdi 183 6 reported report VBN cord-252725-e3pazjdi 183 7 antiviral antiviral JJ cord-252725-e3pazjdi 183 8 activity activity NN cord-252725-e3pazjdi 183 9 of of IN cord-252725-e3pazjdi 183 10 caffeic caffeic NNS cord-252725-e3pazjdi 183 11 acid acid NN cord-252725-e3pazjdi 183 12 towards towards IN cord-252725-e3pazjdi 183 13 herpes herpes NN cord-252725-e3pazjdi 183 14 simplex simplex NNP cord-252725-e3pazjdi 183 15 ( ( -LRB- cord-252725-e3pazjdi 183 16 HSV HSV NNP cord-252725-e3pazjdi 183 17 ) ) -RRB- cord-252725-e3pazjdi 183 18 , , , cord-252725-e3pazjdi 183 19 VSV VSV NNP cord-252725-e3pazjdi 183 20 - - HYPH cord-252725-e3pazjdi 183 21 Ebola Ebola NNP cord-252725-e3pazjdi 183 22 pseudotyped pseudotyped NNS cord-252725-e3pazjdi 183 23 and and CC cord-252725-e3pazjdi 183 24 vaccinia vaccinia NN cord-252725-e3pazjdi 183 25 viruses virus NNS cord-252725-e3pazjdi 183 26 and and CC cord-252725-e3pazjdi 183 27 that that IN cord-252725-e3pazjdi 183 28 antiviral antiviral JJ cord-252725-e3pazjdi 183 29 activity activity NN cord-252725-e3pazjdi 183 30 increased increase VBD cord-252725-e3pazjdi 183 31 and and CC cord-252725-e3pazjdi 183 32 occurred occur VBD cord-252725-e3pazjdi 183 33 early early RB cord-252725-e3pazjdi 183 34 in in IN cord-252725-e3pazjdi 183 35 the the DT cord-252725-e3pazjdi 183 36 virus virus NN cord-252725-e3pazjdi 183 37 replication replication NN cord-252725-e3pazjdi 183 38 cycle cycle NN cord-252725-e3pazjdi 183 39 with with IN cord-252725-e3pazjdi 183 40 the the DT cord-252725-e3pazjdi 183 41 addition addition NN cord-252725-e3pazjdi 183 42 of of IN cord-252725-e3pazjdi 183 43 chelated chelated JJ cord-252725-e3pazjdi 183 44 inorganic inorganic JJ cord-252725-e3pazjdi 183 45 ions ion NNS cord-252725-e3pazjdi 183 46 or or CC cord-252725-e3pazjdi 183 47 a a DT cord-252725-e3pazjdi 183 48 metal metal NN cord-252725-e3pazjdi 183 49 such such JJ cord-252725-e3pazjdi 183 50 as as IN cord-252725-e3pazjdi 183 51 iron iron NN cord-252725-e3pazjdi 183 52 to to IN cord-252725-e3pazjdi 183 53 caffeic caffeic VB cord-252725-e3pazjdi 183 54 acid acid NN cord-252725-e3pazjdi 183 55 [ [ -LRB- cord-252725-e3pazjdi 183 56 126 126 CD cord-252725-e3pazjdi 183 57 ] ] -RRB- cord-252725-e3pazjdi 183 58 . . . cord-252725-e3pazjdi 184 1 Caffeic Caffeic NNP cord-252725-e3pazjdi 184 2 acid acid NN cord-252725-e3pazjdi 184 3 and and CC cord-252725-e3pazjdi 184 4 its -PRON- PRP$ cord-252725-e3pazjdi 184 5 derivatives derivative NNS cord-252725-e3pazjdi 184 6 have have VBP cord-252725-e3pazjdi 184 7 uncountable uncountable JJ cord-252725-e3pazjdi 184 8 antiviral antiviral JJ cord-252725-e3pazjdi 184 9 activities activity NNS cord-252725-e3pazjdi 184 10 that that WDT cord-252725-e3pazjdi 184 11 may may MD cord-252725-e3pazjdi 184 12 be be VB cord-252725-e3pazjdi 184 13 used use VBN cord-252725-e3pazjdi 184 14 against against IN cord-252725-e3pazjdi 184 15 the the DT cord-252725-e3pazjdi 184 16 spread spread NN cord-252725-e3pazjdi 184 17 of of IN cord-252725-e3pazjdi 184 18 emerging emerge VBG cord-252725-e3pazjdi 184 19 COVID-19 covid-19 NN cord-252725-e3pazjdi 184 20 and and CC cord-252725-e3pazjdi 184 21 its -PRON- PRP$ cord-252725-e3pazjdi 184 22 related related JJ cord-252725-e3pazjdi 184 23 symptoms symptom NNS cord-252725-e3pazjdi 184 24 . . . cord-252725-e3pazjdi 185 1 Daidzein Daidzein NNP cord-252725-e3pazjdi 185 2 ( ( -LRB- cord-252725-e3pazjdi 185 3 4′,7-dihydroxyisoflavone 4′,7-dihydroxyisoflavone CD cord-252725-e3pazjdi 185 4 ) ) -RRB- cord-252725-e3pazjdi 186 1 ( ( -LRB- cord-252725-e3pazjdi 186 2 Fig Fig NNP cord-252725-e3pazjdi 186 3 . . . cord-252725-e3pazjdi 186 4 12 12 CD cord-252725-e3pazjdi 186 5 ) ) -RRB- cord-252725-e3pazjdi 186 6 is be VBZ cord-252725-e3pazjdi 186 7 a a DT cord-252725-e3pazjdi 186 8 naturally naturally RB cord-252725-e3pazjdi 186 9 occurring occur VBG cord-252725-e3pazjdi 186 10 isoflavone isoflavone NN cord-252725-e3pazjdi 186 11 compound compound NN cord-252725-e3pazjdi 186 12 found find VBN cord-252725-e3pazjdi 186 13 in in IN cord-252725-e3pazjdi 186 14 high high JJ cord-252725-e3pazjdi 186 15 concentrations concentration NNS cord-252725-e3pazjdi 186 16 in in IN cord-252725-e3pazjdi 186 17 soybeans soybean NNS cord-252725-e3pazjdi 186 18 , , , cord-252725-e3pazjdi 186 19 soy soy NN cord-252725-e3pazjdi 186 20 products product NNS cord-252725-e3pazjdi 186 21 like like IN cord-252725-e3pazjdi 186 22 tofu tofu NN cord-252725-e3pazjdi 186 23 and and CC cord-252725-e3pazjdi 186 24 textured textured JJ cord-252725-e3pazjdi 186 25 vegetable vegetable NN cord-252725-e3pazjdi 186 26 protein protein NN cord-252725-e3pazjdi 186 27 , , , cord-252725-e3pazjdi 186 28 red red JJ cord-252725-e3pazjdi 186 29 clover clover NN cord-252725-e3pazjdi 186 30 and and CC cord-252725-e3pazjdi 186 31 also also RB cord-252725-e3pazjdi 186 32 in in IN cord-252725-e3pazjdi 186 33 some some DT cord-252725-e3pazjdi 186 34 herbs herb NNS cord-252725-e3pazjdi 186 35 such such JJ cord-252725-e3pazjdi 186 36 as as IN cord-252725-e3pazjdi 186 37 Vitex Vitex NNP cord-252725-e3pazjdi 186 38 Agnus Agnus NNP cord-252725-e3pazjdi 186 39 Castus Castus NNP cord-252725-e3pazjdi 186 40 and and CC cord-252725-e3pazjdi 186 41 Black Black NNP cord-252725-e3pazjdi 186 42 Cohosh Cohosh NNP cord-252725-e3pazjdi 186 43 . . . cord-252725-e3pazjdi 187 1 It -PRON- PRP cord-252725-e3pazjdi 187 2 is be VBZ cord-252725-e3pazjdi 187 3 also also RB cord-252725-e3pazjdi 187 4 present present JJ cord-252725-e3pazjdi 187 5 in in IN cord-252725-e3pazjdi 187 6 many many JJ cord-252725-e3pazjdi 187 7 other other JJ cord-252725-e3pazjdi 187 8 vegetables vegetable NNS cord-252725-e3pazjdi 187 9 , , , cord-252725-e3pazjdi 187 10 fruits fruit NNS cord-252725-e3pazjdi 187 11 , , , cord-252725-e3pazjdi 187 12 nuts nut NNS cord-252725-e3pazjdi 187 13 , , , cord-252725-e3pazjdi 187 14 peas pea NNS cord-252725-e3pazjdi 187 15 , , , cord-252725-e3pazjdi 187 16 lentils lentil NNS cord-252725-e3pazjdi 187 17 , , , cord-252725-e3pazjdi 187 18 various various JJ cord-252725-e3pazjdi 187 19 cereals cereal NNS cord-252725-e3pazjdi 187 20 , , , cord-252725-e3pazjdi 187 21 bakery bakery NN cord-252725-e3pazjdi 187 22 products product NNS cord-252725-e3pazjdi 187 23 , , , cord-252725-e3pazjdi 187 24 milk milk NN cord-252725-e3pazjdi 187 25 , , , cord-252725-e3pazjdi 187 26 meat meat NN cord-252725-e3pazjdi 187 27 and and CC cord-252725-e3pazjdi 187 28 other other JJ cord-252725-e3pazjdi 187 29 food food NN cord-252725-e3pazjdi 187 30 products product NNS cord-252725-e3pazjdi 187 31 [ [ -LRB- cord-252725-e3pazjdi 187 32 127 127 CD cord-252725-e3pazjdi 187 33 , , , cord-252725-e3pazjdi 187 34 128 128 CD cord-252725-e3pazjdi 187 35 ] ] -RRB- cord-252725-e3pazjdi 187 36 . . . cord-252725-e3pazjdi 188 1 Daidzein Daidzein NNP cord-252725-e3pazjdi 188 2 is be VBZ cord-252725-e3pazjdi 188 3 classified classify VBN cord-252725-e3pazjdi 188 4 as as IN cord-252725-e3pazjdi 188 5 a a DT cord-252725-e3pazjdi 188 6 phytoestrogen phytoestrogen NN cord-252725-e3pazjdi 188 7 because because IN cord-252725-e3pazjdi 188 8 it -PRON- PRP cord-252725-e3pazjdi 188 9 has have VBZ cord-252725-e3pazjdi 188 10 oestrogen oestrogen NN cord-252725-e3pazjdi 188 11 - - HYPH cord-252725-e3pazjdi 188 12 like like JJ cord-252725-e3pazjdi 188 13 properties property NNS cord-252725-e3pazjdi 188 14 ; ; : cord-252725-e3pazjdi 188 15 with with IN cord-252725-e3pazjdi 188 16 its -PRON- PRP$ cord-252725-e3pazjdi 188 17 partner partner NN cord-252725-e3pazjdi 188 18 genistein genistein NNP cord-252725-e3pazjdi 188 19 , , , cord-252725-e3pazjdi 188 20 daidzein daidzein NNP cord-252725-e3pazjdi 188 21 compromises compromise VBZ cord-252725-e3pazjdi 188 22 90 90 CD cord-252725-e3pazjdi 188 23 % % NN cord-252725-e3pazjdi 188 24 of of IN cord-252725-e3pazjdi 188 25 the the DT cord-252725-e3pazjdi 188 26 intake intake NN cord-252725-e3pazjdi 188 27 of of IN cord-252725-e3pazjdi 188 28 oestrogenic oestrogenic NNP cord-252725-e3pazjdi 188 29 isofalvones isofalvone NNS cord-252725-e3pazjdi 188 30 from from IN cord-252725-e3pazjdi 188 31 the the DT cord-252725-e3pazjdi 188 32 diet diet NN cord-252725-e3pazjdi 188 33 [ [ -LRB- cord-252725-e3pazjdi 188 34 127 127 CD cord-252725-e3pazjdi 188 35 , , , cord-252725-e3pazjdi 188 36 129 129 CD cord-252725-e3pazjdi 188 37 ] ] -RRB- cord-252725-e3pazjdi 188 38 . . . cord-252725-e3pazjdi 189 1 Daidzein Daidzein NNP cord-252725-e3pazjdi 189 2 has have VBZ cord-252725-e3pazjdi 189 3 several several JJ cord-252725-e3pazjdi 189 4 biological biological JJ cord-252725-e3pazjdi 189 5 and and CC cord-252725-e3pazjdi 189 6 pharmacological pharmacological JJ cord-252725-e3pazjdi 189 7 properties property NNS cord-252725-e3pazjdi 189 8 for for IN cord-252725-e3pazjdi 189 9 instance instance NN cord-252725-e3pazjdi 189 10 antioxidant antioxidant NN cord-252725-e3pazjdi 189 11 , , , cord-252725-e3pazjdi 189 12 anticancer anticancer JJ cord-252725-e3pazjdi 189 13 , , , cord-252725-e3pazjdi 189 14 anti anti JJ cord-252725-e3pazjdi 189 15 - - JJ cord-252725-e3pazjdi 189 16 inflammatory inflammatory JJ cord-252725-e3pazjdi 189 17 , , , cord-252725-e3pazjdi 189 18 neuroprotective neuroprotective JJ cord-252725-e3pazjdi 189 19 , , , cord-252725-e3pazjdi 189 20 protective protective JJ cord-252725-e3pazjdi 189 21 treatment treatment NN cord-252725-e3pazjdi 189 22 of of IN cord-252725-e3pazjdi 189 23 cardiovascular cardiovascular JJ cord-252725-e3pazjdi 189 24 diseases disease NNS cord-252725-e3pazjdi 189 25 , , , cord-252725-e3pazjdi 189 26 and and CC cord-252725-e3pazjdi 189 27 autoimmune autoimmune JJ cord-252725-e3pazjdi 189 28 diseases disease NNS cord-252725-e3pazjdi 189 29 [ [ -LRB- cord-252725-e3pazjdi 189 30 130 130 CD cord-252725-e3pazjdi 189 31 ] ] -RRB- cord-252725-e3pazjdi 189 32 . . . cord-252725-e3pazjdi 190 1 Soy soy NN cord-252725-e3pazjdi 190 2 isoflavones isoflavone NNS cord-252725-e3pazjdi 190 3 consumption consumption NN cord-252725-e3pazjdi 190 4 such such JJ cord-252725-e3pazjdi 190 5 as as IN cord-252725-e3pazjdi 190 6 genistein genistein NNP cord-252725-e3pazjdi 190 7 , , , cord-252725-e3pazjdi 190 8 daidzein daidzein NNP cord-252725-e3pazjdi 190 9 , , , cord-252725-e3pazjdi 190 10 and and CC cord-252725-e3pazjdi 190 11 glycitein glycitein NNP cord-252725-e3pazjdi 190 12 has have VBZ cord-252725-e3pazjdi 190 13 been be VBN cord-252725-e3pazjdi 190 14 associated associate VBN cord-252725-e3pazjdi 190 15 with with IN cord-252725-e3pazjdi 190 16 a a DT cord-252725-e3pazjdi 190 17 reduced reduce VBN cord-252725-e3pazjdi 190 18 prevalence prevalence NN cord-252725-e3pazjdi 190 19 of of IN cord-252725-e3pazjdi 190 20 chronic chronic JJ cord-252725-e3pazjdi 190 21 health health NN cord-252725-e3pazjdi 190 22 disorders disorder NNS cord-252725-e3pazjdi 190 23 and and CC cord-252725-e3pazjdi 190 24 regulation regulation NN cord-252725-e3pazjdi 190 25 of of IN cord-252725-e3pazjdi 190 26 the the DT cord-252725-e3pazjdi 190 27 immune immune JJ cord-252725-e3pazjdi 190 28 response response NN cord-252725-e3pazjdi 190 29 , , , cord-252725-e3pazjdi 190 30 which which WDT cord-252725-e3pazjdi 190 31 give give VBP cord-252725-e3pazjdi 190 32 them -PRON- PRP cord-252725-e3pazjdi 190 33 an an DT cord-252725-e3pazjdi 190 34 important important JJ cord-252725-e3pazjdi 190 35 potential potential JJ cord-252725-e3pazjdi 190 36 role role NN cord-252725-e3pazjdi 190 37 in in IN cord-252725-e3pazjdi 190 38 clinical clinical JJ cord-252725-e3pazjdi 190 39 applications application NNS cord-252725-e3pazjdi 190 40 in in IN cord-252725-e3pazjdi 190 41 immune immune JJ cord-252725-e3pazjdi 190 42 - - HYPH cord-252725-e3pazjdi 190 43 dysfunction dysfunction NN cord-252725-e3pazjdi 190 44 [ [ -LRB- cord-252725-e3pazjdi 190 45 131 131 CD cord-252725-e3pazjdi 190 46 ] ] -RRB- cord-252725-e3pazjdi 190 47 . . . cord-252725-e3pazjdi 191 1 Daidzein Daidzein NNP cord-252725-e3pazjdi 191 2 markedly markedly RB cord-252725-e3pazjdi 191 3 attenuated attenuate VBN cord-252725-e3pazjdi 191 4 TNF TNF NNP cord-252725-e3pazjdi 191 5 - - HYPH cord-252725-e3pazjdi 191 6 α α NN cord-252725-e3pazjdi 191 7 - - HYPH cord-252725-e3pazjdi 191 8 induced induce VBN cord-252725-e3pazjdi 191 9 lung lung NN cord-252725-e3pazjdi 191 10 inflammation inflammation NN cord-252725-e3pazjdi 191 11 and and CC cord-252725-e3pazjdi 191 12 lipopolysaccharide lipopolysaccharide NN cord-252725-e3pazjdi 191 13 - - HYPH cord-252725-e3pazjdi 191 14 induced induce VBN cord-252725-e3pazjdi 191 15 acute acute JJ cord-252725-e3pazjdi 191 16 lung lung NN cord-252725-e3pazjdi 191 17 injury injury NN cord-252725-e3pazjdi 191 18 through through IN cord-252725-e3pazjdi 191 19 blocking blocking NN cord-252725-e3pazjdi 191 20 of of IN cord-252725-e3pazjdi 191 21 NF nf NN cord-252725-e3pazjdi 191 22 - - HYPH cord-252725-e3pazjdi 191 23 κB κB NNP cord-252725-e3pazjdi 191 24 pathway pathway NN cord-252725-e3pazjdi 191 25 via via IN cord-252725-e3pazjdi 191 26 different different JJ cord-252725-e3pazjdi 191 27 interaction interaction NN cord-252725-e3pazjdi 191 28 mechanisms mechanism NNS cord-252725-e3pazjdi 191 29 , , , cord-252725-e3pazjdi 191 30 which which WDT cord-252725-e3pazjdi 191 31 inhibited inhibit VBD cord-252725-e3pazjdi 191 32 several several JJ cord-252725-e3pazjdi 191 33 pro pro JJ cord-252725-e3pazjdi 191 34 - - JJ cord-252725-e3pazjdi 191 35 inflammatory inflammatory JJ cord-252725-e3pazjdi 191 36 markers marker NNS cord-252725-e3pazjdi 191 37 such such JJ cord-252725-e3pazjdi 191 38 as as IN cord-252725-e3pazjdi 191 39 Cxcl2 Cxcl2 VBN cord-252725-e3pazjdi 191 40 in in IN cord-252725-e3pazjdi 191 41 lung lung NN cord-252725-e3pazjdi 191 42 tissues tissue NNS cord-252725-e3pazjdi 191 43 [ [ -LRB- cord-252725-e3pazjdi 191 44 132 132 CD cord-252725-e3pazjdi 191 45 ] ] -RRB- cord-252725-e3pazjdi 191 46 . . . cord-252725-e3pazjdi 192 1 Moreover moreover RB cord-252725-e3pazjdi 192 2 , , , cord-252725-e3pazjdi 192 3 a a DT cord-252725-e3pazjdi 192 4 study study NN cord-252725-e3pazjdi 192 5 has have VBZ cord-252725-e3pazjdi 192 6 reported report VBN cord-252725-e3pazjdi 192 7 that that IN cord-252725-e3pazjdi 192 8 daidzein daidzein NNP cord-252725-e3pazjdi 192 9 exhibits exhibit VBZ cord-252725-e3pazjdi 192 10 an an DT cord-252725-e3pazjdi 192 11 anti anti JJ cord-252725-e3pazjdi 192 12 - - JJ cord-252725-e3pazjdi 192 13 fibrotic fibrotic JJ cord-252725-e3pazjdi 192 14 effect effect NN cord-252725-e3pazjdi 192 15 against against IN cord-252725-e3pazjdi 192 16 Bleomycin Bleomycin NNP cord-252725-e3pazjdi 192 17 ( ( -LRB- cord-252725-e3pazjdi 192 18 BLM BLM NNP cord-252725-e3pazjdi 192 19 ) ) -RRB- cord-252725-e3pazjdi 192 20 induced induce VBN cord-252725-e3pazjdi 192 21 pulmonary pulmonary JJ cord-252725-e3pazjdi 192 22 fibrosis fibrosis NN cord-252725-e3pazjdi 192 23 ( ( -LRB- cord-252725-e3pazjdi 192 24 PF PF NNP cord-252725-e3pazjdi 192 25 ) ) -RRB- cord-252725-e3pazjdi 192 26 in in IN cord-252725-e3pazjdi 192 27 rats rat NNS cord-252725-e3pazjdi 192 28 [ [ -LRB- cord-252725-e3pazjdi 192 29 133 133 CD cord-252725-e3pazjdi 192 30 ] ] -RRB- cord-252725-e3pazjdi 192 31 . . . cord-252725-e3pazjdi 193 1 Furthermore furthermore RB cord-252725-e3pazjdi 193 2 , , , cord-252725-e3pazjdi 193 3 during during IN cord-252725-e3pazjdi 193 4 influenza influenza NN cord-252725-e3pazjdi 193 5 infection infection NN cord-252725-e3pazjdi 193 6 , , , cord-252725-e3pazjdi 193 7 reactive reactive JJ cord-252725-e3pazjdi 193 8 oxygen oxygen NN cord-252725-e3pazjdi 193 9 species specie NNS cord-252725-e3pazjdi 193 10 ( ( -LRB- cord-252725-e3pazjdi 193 11 ROS ROS NNP cord-252725-e3pazjdi 193 12 ) ) -RRB- cord-252725-e3pazjdi 193 13 and and CC cord-252725-e3pazjdi 193 14 lipid lipid NN cord-252725-e3pazjdi 193 15 peroxides peroxide NNS cord-252725-e3pazjdi 193 16 are be VBP cord-252725-e3pazjdi 193 17 generated generate VBN cord-252725-e3pazjdi 193 18 in in IN cord-252725-e3pazjdi 193 19 several several JJ cord-252725-e3pazjdi 193 20 tissues tissue NNS cord-252725-e3pazjdi 193 21 such such JJ cord-252725-e3pazjdi 193 22 as as IN cord-252725-e3pazjdi 193 23 the the DT cord-252725-e3pazjdi 193 24 lung lung NN cord-252725-e3pazjdi 193 25 , , , cord-252725-e3pazjdi 193 26 and and CC cord-252725-e3pazjdi 193 27 daidzein daidzein NNP cord-252725-e3pazjdi 193 28 was be VBD cord-252725-e3pazjdi 193 29 reported report VBN cord-252725-e3pazjdi 193 30 to to TO cord-252725-e3pazjdi 193 31 exert exert VB cord-252725-e3pazjdi 193 32 an an DT cord-252725-e3pazjdi 193 33 antiviral antiviral JJ cord-252725-e3pazjdi 193 34 activity activity NN cord-252725-e3pazjdi 193 35 through through IN cord-252725-e3pazjdi 193 36 its -PRON- PRP$ cord-252725-e3pazjdi 193 37 antioxidant antioxidant JJ cord-252725-e3pazjdi 193 38 capacity capacity NN cord-252725-e3pazjdi 193 39 to to TO cord-252725-e3pazjdi 193 40 decease decease VB cord-252725-e3pazjdi 193 41 ROS ROS NNP cord-252725-e3pazjdi 193 42 and and CC cord-252725-e3pazjdi 193 43 lipid lipid NN cord-252725-e3pazjdi 193 44 peroxide peroxide NN cord-252725-e3pazjdi 193 45 generations generation NNS cord-252725-e3pazjdi 193 46 . . . cord-252725-e3pazjdi 194 1 Consequently consequently RB cord-252725-e3pazjdi 194 2 , , , cord-252725-e3pazjdi 194 3 daidzein daidzein NNP cord-252725-e3pazjdi 194 4 regulates regulate VBZ cord-252725-e3pazjdi 194 5 influenza influenza NN cord-252725-e3pazjdi 194 6 virus virus NN cord-252725-e3pazjdi 194 7 replication replication NN cord-252725-e3pazjdi 194 8 via via IN cord-252725-e3pazjdi 194 9 signal signal NN cord-252725-e3pazjdi 194 10 transduction transduction NN cord-252725-e3pazjdi 194 11 through through IN cord-252725-e3pazjdi 194 12 5-lipoxygenase 5-lipoxygenase CD cord-252725-e3pazjdi 194 13 products product NNS cord-252725-e3pazjdi 194 14 induced induce VBN cord-252725-e3pazjdi 194 15 by by IN cord-252725-e3pazjdi 194 16 daidzein daidzein NNP cord-252725-e3pazjdi 194 17 [ [ -LRB- cord-252725-e3pazjdi 194 18 134 134 CD cord-252725-e3pazjdi 194 19 ] ] -RRB- cord-252725-e3pazjdi 194 20 . . . cord-252725-e3pazjdi 195 1 Also also RB cord-252725-e3pazjdi 195 2 , , , cord-252725-e3pazjdi 195 3 novel novel JJ cord-252725-e3pazjdi 195 4 daidzein daidzein NNP cord-252725-e3pazjdi 195 5 analog analog NN cord-252725-e3pazjdi 195 6 compounds compound NNS cord-252725-e3pazjdi 195 7 synthesized synthesize VBN cord-252725-e3pazjdi 195 8 based base VBN cord-252725-e3pazjdi 195 9 on on IN cord-252725-e3pazjdi 195 10 structural structural JJ cord-252725-e3pazjdi 195 11 modifications modification NNS cord-252725-e3pazjdi 195 12 of of IN cord-252725-e3pazjdi 195 13 daidzein daidzein NNP cord-252725-e3pazjdi 195 14 have have VBP cord-252725-e3pazjdi 195 15 been be VBN cord-252725-e3pazjdi 195 16 demonstrated demonstrate VBN cord-252725-e3pazjdi 195 17 in in IN cord-252725-e3pazjdi 195 18 vitro vitro FW cord-252725-e3pazjdi 195 19 a a DT cord-252725-e3pazjdi 195 20 selective selective JJ cord-252725-e3pazjdi 195 21 antiviral antiviral JJ cord-252725-e3pazjdi 195 22 agent agent NN cord-252725-e3pazjdi 195 23 against against IN cord-252725-e3pazjdi 195 24 H1N1 H1N1 NNP cord-252725-e3pazjdi 195 25 TR TR NNP cord-252725-e3pazjdi 195 26 influenza influenza NN cord-252725-e3pazjdi 195 27 viruses virus NNS cord-252725-e3pazjdi 195 28 [ [ -LRB- cord-252725-e3pazjdi 195 29 135 135 CD cord-252725-e3pazjdi 195 30 ] ] -RRB- cord-252725-e3pazjdi 195 31 . . . cord-252725-e3pazjdi 196 1 Due due IN cord-252725-e3pazjdi 196 2 to to IN cord-252725-e3pazjdi 196 3 their -PRON- PRP$ cord-252725-e3pazjdi 196 4 role role NN cord-252725-e3pazjdi 196 5 in in IN cord-252725-e3pazjdi 196 6 the the DT cord-252725-e3pazjdi 196 7 regulation regulation NN cord-252725-e3pazjdi 196 8 of of IN cord-252725-e3pazjdi 196 9 immune immune JJ cord-252725-e3pazjdi 196 10 responses response NNS cord-252725-e3pazjdi 196 11 and and CC cord-252725-e3pazjdi 196 12 antioxidant antioxidant JJ cord-252725-e3pazjdi 196 13 activity activity NN cord-252725-e3pazjdi 196 14 , , , cord-252725-e3pazjdi 196 15 daidzein daidzein NNP cord-252725-e3pazjdi 196 16 could could MD cord-252725-e3pazjdi 196 17 be be VB cord-252725-e3pazjdi 196 18 applied apply VBN cord-252725-e3pazjdi 196 19 to to TO cord-252725-e3pazjdi 196 20 enhance enhance VB cord-252725-e3pazjdi 196 21 body body NN cord-252725-e3pazjdi 196 22 immunity immunity NN cord-252725-e3pazjdi 196 23 against against IN cord-252725-e3pazjdi 196 24 emergence emergence NN cord-252725-e3pazjdi 196 25 diseases disease NNS cord-252725-e3pazjdi 196 26 such such JJ cord-252725-e3pazjdi 196 27 as as IN cord-252725-e3pazjdi 196 28 COVID-19 covid-19 CD cord-252725-e3pazjdi 196 29 and and CC cord-252725-e3pazjdi 196 30 related related JJ cord-252725-e3pazjdi 196 31 immunity immunity NN cord-252725-e3pazjdi 196 32 dysfunctions dysfunction NNS cord-252725-e3pazjdi 196 33 . . . cord-252725-e3pazjdi 197 1 Chrysin Chrysin NNP cord-252725-e3pazjdi 197 2 ( ( -LRB- cord-252725-e3pazjdi 197 3 5,7-dihydroxyflavone 5,7-dihydroxyflavone CD cord-252725-e3pazjdi 197 4 , , , cord-252725-e3pazjdi 197 5 also also RB cord-252725-e3pazjdi 197 6 known know VBN cord-252725-e3pazjdi 197 7 as as IN cord-252725-e3pazjdi 197 8 vitamin vitamin NN cord-252725-e3pazjdi 197 9 P p NN cord-252725-e3pazjdi 197 10 ) ) -RRB- cord-252725-e3pazjdi 197 11 ( ( -LRB- cord-252725-e3pazjdi 197 12 Fig Fig NNP cord-252725-e3pazjdi 197 13 . . NNP cord-252725-e3pazjdi 197 14 13 13 CD cord-252725-e3pazjdi 197 15 ) ) -RRB- cord-252725-e3pazjdi 198 1 Chrysin Chrysin NNP cord-252725-e3pazjdi 198 2 exhibits exhibit VBZ cord-252725-e3pazjdi 198 3 many many JJ cord-252725-e3pazjdi 198 4 biological biological JJ cord-252725-e3pazjdi 198 5 activities activity NNS cord-252725-e3pazjdi 198 6 and and CC cord-252725-e3pazjdi 198 7 pharmacological pharmacological JJ cord-252725-e3pazjdi 198 8 effects effect NNS cord-252725-e3pazjdi 198 9 , , , cord-252725-e3pazjdi 198 10 including include VBG cord-252725-e3pazjdi 198 11 antioxidant antioxidant JJ cord-252725-e3pazjdi 198 12 , , , cord-252725-e3pazjdi 198 13 anti anti JJ cord-252725-e3pazjdi 198 14 - - JJ cord-252725-e3pazjdi 198 15 inflammatory inflammatory JJ cord-252725-e3pazjdi 198 16 , , , cord-252725-e3pazjdi 198 17 anticancer anticancer JJ cord-252725-e3pazjdi 198 18 , , , cord-252725-e3pazjdi 198 19 pro pro JJ cord-252725-e3pazjdi 198 20 - - JJ cord-252725-e3pazjdi 198 21 apoptotic apoptotic JJ cord-252725-e3pazjdi 198 22 , , , cord-252725-e3pazjdi 198 23 antiangiogenic antiangiogenic NNP cord-252725-e3pazjdi 198 24 , , , cord-252725-e3pazjdi 198 25 antimetastatic antimetastatic NNP cord-252725-e3pazjdi 198 26 , , , cord-252725-e3pazjdi 198 27 immunomodulatory immunomodulatory NNP cord-252725-e3pazjdi 198 28 , , , cord-252725-e3pazjdi 198 29 antiasthmatic antiasthmatic NNP cord-252725-e3pazjdi 198 30 , , , cord-252725-e3pazjdi 198 31 antibacterial antibacterial JJ cord-252725-e3pazjdi 198 32 and and CC cord-252725-e3pazjdi 198 33 antiviral antiviral JJ cord-252725-e3pazjdi 198 34 activities activity NNS cord-252725-e3pazjdi 198 35 [ [ -LRB- cord-252725-e3pazjdi 198 36 136 136 CD cord-252725-e3pazjdi 198 37 , , , cord-252725-e3pazjdi 198 38 137 137 CD cord-252725-e3pazjdi 198 39 ] ] -RRB- cord-252725-e3pazjdi 198 40 . . . cord-252725-e3pazjdi 199 1 Actually actually RB cord-252725-e3pazjdi 199 2 , , , cord-252725-e3pazjdi 199 3 chrysin chrysin NNP cord-252725-e3pazjdi 199 4 exerts exert VBZ cord-252725-e3pazjdi 199 5 its -PRON- PRP$ cord-252725-e3pazjdi 199 6 activities activity NNS cord-252725-e3pazjdi 199 7 against against IN cord-252725-e3pazjdi 199 8 various various JJ cord-252725-e3pazjdi 199 9 diseases disease NNS cord-252725-e3pazjdi 199 10 by by IN cord-252725-e3pazjdi 199 11 different different JJ cord-252725-e3pazjdi 199 12 mechanisms mechanism NNS cord-252725-e3pazjdi 199 13 including include VBG cord-252725-e3pazjdi 199 14 the the DT cord-252725-e3pazjdi 199 15 suppression suppression NN cord-252725-e3pazjdi 199 16 of of IN cord-252725-e3pazjdi 199 17 inducible inducible JJ cord-252725-e3pazjdi 199 18 nitric nitric NN cord-252725-e3pazjdi 199 19 oxide oxide NN cord-252725-e3pazjdi 199 20 synthase synthase NN cord-252725-e3pazjdi 199 21 ( ( -LRB- cord-252725-e3pazjdi 199 22 iNOS inos NN cord-252725-e3pazjdi 199 23 ) ) -RRB- cord-252725-e3pazjdi 199 24 and and CC cord-252725-e3pazjdi 199 25 NF nf NN cord-252725-e3pazjdi 199 26 - - HYPH cord-252725-e3pazjdi 199 27 κB κB NNP cord-252725-e3pazjdi 199 28 , , , cord-252725-e3pazjdi 199 29 inhibition inhibition NN cord-252725-e3pazjdi 199 30 of of IN cord-252725-e3pazjdi 199 31 histone histone JJ cord-252725-e3pazjdi 199 32 deacetylase deacetylase NN cord-252725-e3pazjdi 199 33 and and CC cord-252725-e3pazjdi 199 34 DNA dna NN cord-252725-e3pazjdi 199 35 topoisomerases topoisomerase NNS cord-252725-e3pazjdi 199 36 , , , cord-252725-e3pazjdi 199 37 inhibition inhibition NN cord-252725-e3pazjdi 199 38 pro pro JJ cord-252725-e3pazjdi 199 39 - - JJ cord-252725-e3pazjdi 199 40 inflammatory inflammatory JJ cord-252725-e3pazjdi 199 41 cytokine cytokine NN cord-252725-e3pazjdi 199 42 expressions expression NNS cord-252725-e3pazjdi 199 43 such such JJ cord-252725-e3pazjdi 199 44 as as IN cord-252725-e3pazjdi 199 45 TNF TNF NNP cord-252725-e3pazjdi 199 46 - - HYPH cord-252725-e3pazjdi 199 47 α α NNP cord-252725-e3pazjdi 199 48 and and CC cord-252725-e3pazjdi 199 49 IL-1β il-1β CC cord-252725-e3pazjdi 199 50 through through IN cord-252725-e3pazjdi 199 51 blocking block VBG cord-252725-e3pazjdi 199 52 histamine histamine NN cord-252725-e3pazjdi 199 53 release release NN cord-252725-e3pazjdi 199 54 and and CC cord-252725-e3pazjdi 199 55 also also RB cord-252725-e3pazjdi 199 56 decreasing decrease VBG cord-252725-e3pazjdi 199 57 matrix matrix NN cord-252725-e3pazjdi 199 58 metalloproteinase-2 metalloproteinase-2 NNP cord-252725-e3pazjdi 199 59 ( ( -LRB- cord-252725-e3pazjdi 199 60 MMP-2 MMP-2 NNP cord-252725-e3pazjdi 199 61 ) ) -RRB- cord-252725-e3pazjdi 199 62 expression expression NN cord-252725-e3pazjdi 199 63 [ [ -LRB- cord-252725-e3pazjdi 199 64 138 138 CD cord-252725-e3pazjdi 199 65 ] ] -RRB- cord-252725-e3pazjdi 199 66 . . . cord-252725-e3pazjdi 200 1 Chrysin Chrysin NNP cord-252725-e3pazjdi 200 2 could could MD cord-252725-e3pazjdi 200 3 also also RB cord-252725-e3pazjdi 200 4 prevent prevent VB cord-252725-e3pazjdi 200 5 airway airway NN cord-252725-e3pazjdi 200 6 inflammation inflammation NN cord-252725-e3pazjdi 200 7 by by IN cord-252725-e3pazjdi 200 8 inhibiting inhibit VBG cord-252725-e3pazjdi 200 9 the the DT cord-252725-e3pazjdi 200 10 release release NN cord-252725-e3pazjdi 200 11 of of IN cord-252725-e3pazjdi 200 12 proinflammatory proinflammatory JJ cord-252725-e3pazjdi 200 13 mediators mediator NNS cord-252725-e3pazjdi 200 14 TNF TNF NNP cord-252725-e3pazjdi 200 15 - - HYPH cord-252725-e3pazjdi 200 16 α α NNP cord-252725-e3pazjdi 200 17 , , , cord-252725-e3pazjdi 200 18 IL-1β IL-1β NNP cord-252725-e3pazjdi 200 19 , , , cord-252725-e3pazjdi 200 20 IL-8 IL-8 NNP cord-252725-e3pazjdi 200 21 , , , cord-252725-e3pazjdi 200 22 and and CC cord-252725-e3pazjdi 200 23 myeloperoxidase myeloperoxidase NNP cord-252725-e3pazjdi 200 24 ( ( -LRB- cord-252725-e3pazjdi 200 25 MOP mop NN cord-252725-e3pazjdi 200 26 ) ) -RRB- cord-252725-e3pazjdi 200 27 expression expression NN cord-252725-e3pazjdi 200 28 via via IN cord-252725-e3pazjdi 200 29 restraining restrain VBG cord-252725-e3pazjdi 200 30 ERK ERK NNP cord-252725-e3pazjdi 200 31 and and CC cord-252725-e3pazjdi 200 32 P38 P38 NNP cord-252725-e3pazjdi 200 33 pathway pathway NN cord-252725-e3pazjdi 200 34 [ [ -LRB- cord-252725-e3pazjdi 200 35 136 136 CD cord-252725-e3pazjdi 200 36 , , , cord-252725-e3pazjdi 200 37 138 138 CD cord-252725-e3pazjdi 200 38 ] ] -RRB- cord-252725-e3pazjdi 200 39 . . . cord-252725-e3pazjdi 201 1 Chrysin Chrysin NNP cord-252725-e3pazjdi 201 2 has have VBZ cord-252725-e3pazjdi 201 3 been be VBN cord-252725-e3pazjdi 201 4 shown show VBN cord-252725-e3pazjdi 201 5 to to TO cord-252725-e3pazjdi 201 6 be be VB cord-252725-e3pazjdi 201 7 a a DT cord-252725-e3pazjdi 201 8 potent potent JJ cord-252725-e3pazjdi 201 9 inhibitor inhibitor NN cord-252725-e3pazjdi 201 10 of of IN cord-252725-e3pazjdi 201 11 human human JJ cord-252725-e3pazjdi 201 12 immunodeficiency immunodeficiency NN cord-252725-e3pazjdi 201 13 virus virus NN cord-252725-e3pazjdi 201 14 ( ( -LRB- cord-252725-e3pazjdi 201 15 HIV HIV NNP cord-252725-e3pazjdi 201 16 ) ) -RRB- cord-252725-e3pazjdi 201 17 and and CC cord-252725-e3pazjdi 201 18 also also RB cord-252725-e3pazjdi 201 19 has have VBZ cord-252725-e3pazjdi 201 20 been be VBN cord-252725-e3pazjdi 201 21 shown show VBN cord-252725-e3pazjdi 201 22 to to TO cord-252725-e3pazjdi 201 23 inhibit inhibit VB cord-252725-e3pazjdi 201 24 the the DT cord-252725-e3pazjdi 201 25 enterovirus enterovirus NN cord-252725-e3pazjdi 201 26 A71 A71 NNP cord-252725-e3pazjdi 201 27 ( ( -LRB- cord-252725-e3pazjdi 201 28 EV EV NNP cord-252725-e3pazjdi 201 29 - - HYPH cord-252725-e3pazjdi 201 30 A71 A71 NNP cord-252725-e3pazjdi 201 31 ) ) -RRB- cord-252725-e3pazjdi 201 32 replication replication NN cord-252725-e3pazjdi 201 33 [ [ -LRB- cord-252725-e3pazjdi 201 34 139 139 CD cord-252725-e3pazjdi 201 35 , , , cord-252725-e3pazjdi 201 36 140 140 CD cord-252725-e3pazjdi 201 37 ] ] -RRB- cord-252725-e3pazjdi 201 38 . . . cord-252725-e3pazjdi 202 1 Moreover moreover RB cord-252725-e3pazjdi 202 2 , , , cord-252725-e3pazjdi 202 3 it -PRON- PRP cord-252725-e3pazjdi 202 4 has have VBZ cord-252725-e3pazjdi 202 5 been be VBN cord-252725-e3pazjdi 202 6 reported report VBN cord-252725-e3pazjdi 202 7 that that IN cord-252725-e3pazjdi 202 8 chrysin chrysin NNP cord-252725-e3pazjdi 202 9 inhibited inhibit VBD cord-252725-e3pazjdi 202 10 the the DT cord-252725-e3pazjdi 202 11 interaction interaction NN cord-252725-e3pazjdi 202 12 between between IN cord-252725-e3pazjdi 202 13 SARS SARS NNP cord-252725-e3pazjdi 202 14 - - HYPH cord-252725-e3pazjdi 202 15 CoV CoV NNP cord-252725-e3pazjdi 202 16 spike spike NN cord-252725-e3pazjdi 202 17 ( ( -LRB- cord-252725-e3pazjdi 202 18 S s NN cord-252725-e3pazjdi 202 19 ) ) -RRB- cord-252725-e3pazjdi 202 20 protein protein NN cord-252725-e3pazjdi 202 21 and and CC cord-252725-e3pazjdi 202 22 angiotensin angiotensin NN cord-252725-e3pazjdi 202 23 - - HYPH cord-252725-e3pazjdi 202 24 converting convert VBG cord-252725-e3pazjdi 202 25 enzyme enzyme NN cord-252725-e3pazjdi 202 26 2 2 CD cord-252725-e3pazjdi 202 27 ( ( -LRB- cord-252725-e3pazjdi 202 28 ACE2 ACE2 NNP cord-252725-e3pazjdi 202 29 ) ) -RRB- cord-252725-e3pazjdi 202 30 which which WDT cord-252725-e3pazjdi 202 31 is be VBZ cord-252725-e3pazjdi 202 32 the the DT cord-252725-e3pazjdi 202 33 functional functional JJ cord-252725-e3pazjdi 202 34 receptor receptor NN cord-252725-e3pazjdi 202 35 for for IN cord-252725-e3pazjdi 202 36 SARS SARS NNP cord-252725-e3pazjdi 202 37 - - HYPH cord-252725-e3pazjdi 202 38 CoV CoV NNP cord-252725-e3pazjdi 202 39 [ [ -LRB- cord-252725-e3pazjdi 202 40 52 52 CD cord-252725-e3pazjdi 202 41 , , , cord-252725-e3pazjdi 202 42 141 141 CD cord-252725-e3pazjdi 202 43 ] ] -RRB- cord-252725-e3pazjdi 202 44 . . . cord-252725-e3pazjdi 203 1 Consequently consequently RB cord-252725-e3pazjdi 203 2 , , , cord-252725-e3pazjdi 203 3 this this DT cord-252725-e3pazjdi 203 4 huge huge JJ cord-252725-e3pazjdi 203 5 capacity capacity NN cord-252725-e3pazjdi 203 6 of of IN cord-252725-e3pazjdi 203 7 chrysin chrysin NN cord-252725-e3pazjdi 203 8 in in IN cord-252725-e3pazjdi 203 9 protecting protect VBG cord-252725-e3pazjdi 203 10 against against IN cord-252725-e3pazjdi 203 11 several several JJ cord-252725-e3pazjdi 203 12 diseases disease NNS cord-252725-e3pazjdi 203 13 especially especially RB cord-252725-e3pazjdi 203 14 virus virus NN cord-252725-e3pazjdi 203 15 infections infection NNS cord-252725-e3pazjdi 203 16 may may MD cord-252725-e3pazjdi 203 17 give give VB cord-252725-e3pazjdi 203 18 it -PRON- PRP cord-252725-e3pazjdi 203 19 a a DT cord-252725-e3pazjdi 203 20 vital vital JJ cord-252725-e3pazjdi 203 21 role role NN cord-252725-e3pazjdi 203 22 in in IN cord-252725-e3pazjdi 203 23 the the DT cord-252725-e3pazjdi 203 24 fight fight NN cord-252725-e3pazjdi 203 25 against against IN cord-252725-e3pazjdi 203 26 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 203 27 principally principally RB cord-252725-e3pazjdi 203 28 , , , cord-252725-e3pazjdi 203 29 via via IN cord-252725-e3pazjdi 203 30 its -PRON- PRP$ cord-252725-e3pazjdi 203 31 ability ability NN cord-252725-e3pazjdi 203 32 to to TO cord-252725-e3pazjdi 203 33 interact interact VB cord-252725-e3pazjdi 203 34 with with IN cord-252725-e3pazjdi 203 35 the the DT cord-252725-e3pazjdi 203 36 virus virus NN cord-252725-e3pazjdi 203 37 receptor receptor NN cord-252725-e3pazjdi 203 38 . . . cord-252725-e3pazjdi 204 1 Ferulic ferulic NN cord-252725-e3pazjdi 204 2 acid acid NN cord-252725-e3pazjdi 204 3 ( ( -LRB- cord-252725-e3pazjdi 204 4 4-hydroxy-3-methoxycinnamicacid 4-hydroxy-3-methoxycinnamicacid CD cord-252725-e3pazjdi 204 5 ) ) -RRB- cord-252725-e3pazjdi 205 1 ( ( -LRB- cord-252725-e3pazjdi 205 2 Fig Fig NNP cord-252725-e3pazjdi 205 3 . . . cord-252725-e3pazjdi 206 1 14 14 LS cord-252725-e3pazjdi 206 2 ) ) -RRB- cord-252725-e3pazjdi 206 3 is be VBZ cord-252725-e3pazjdi 206 4 a a DT cord-252725-e3pazjdi 206 5 phenolic phenolic JJ cord-252725-e3pazjdi 206 6 acid acid NN cord-252725-e3pazjdi 206 7 generally generally RB cord-252725-e3pazjdi 206 8 found find VBN cord-252725-e3pazjdi 206 9 in in IN cord-252725-e3pazjdi 206 10 plant plant NN cord-252725-e3pazjdi 206 11 cell cell NN cord-252725-e3pazjdi 206 12 walls wall NNS cord-252725-e3pazjdi 206 13 such such JJ cord-252725-e3pazjdi 206 14 as as IN cord-252725-e3pazjdi 206 15 whole whole JJ cord-252725-e3pazjdi 206 16 grains grain NNS cord-252725-e3pazjdi 206 17 , , , cord-252725-e3pazjdi 206 18 spinach spinach NN cord-252725-e3pazjdi 206 19 , , , cord-252725-e3pazjdi 206 20 parsley parsley NN cord-252725-e3pazjdi 206 21 , , , cord-252725-e3pazjdi 206 22 grapes grape NNS cord-252725-e3pazjdi 206 23 , , , cord-252725-e3pazjdi 206 24 rhubarb rhubarb NN cord-252725-e3pazjdi 206 25 , , , cord-252725-e3pazjdi 206 26 coffee coffee NN cord-252725-e3pazjdi 206 27 and and CC cord-252725-e3pazjdi 206 28 cereal cereal NN cord-252725-e3pazjdi 206 29 seeds seed NNS cord-252725-e3pazjdi 206 30 , , , cord-252725-e3pazjdi 206 31 mainly mainly RB cord-252725-e3pazjdi 206 32 wheat wheat NN cord-252725-e3pazjdi 206 33 , , , cord-252725-e3pazjdi 206 34 oats oats NN cord-252725-e3pazjdi 206 35 , , , cord-252725-e3pazjdi 206 36 rye rye NN cord-252725-e3pazjdi 206 37 , , , cord-252725-e3pazjdi 206 38 rice rice NN cord-252725-e3pazjdi 206 39 barley barley NN cord-252725-e3pazjdi 206 40 , , , cord-252725-e3pazjdi 206 41 pineapple pineapple NN cord-252725-e3pazjdi 206 42 , , , cord-252725-e3pazjdi 206 43 maize maize NN cord-252725-e3pazjdi 206 44 bran bran NN cord-252725-e3pazjdi 206 45 , , , cord-252725-e3pazjdi 206 46 some some DT cord-252725-e3pazjdi 206 47 fruits fruit NNS cord-252725-e3pazjdi 206 48 such such JJ cord-252725-e3pazjdi 206 49 as as IN cord-252725-e3pazjdi 206 50 eggplant eggplant NN cord-252725-e3pazjdi 206 51 , , , cord-252725-e3pazjdi 206 52 orange orange NN cord-252725-e3pazjdi 206 53 and and CC cord-252725-e3pazjdi 206 54 grapefruit grapefruit NN cord-252725-e3pazjdi 206 55 , , , cord-252725-e3pazjdi 206 56 vegetables vegetable NNS cord-252725-e3pazjdi 206 57 such such JJ cord-252725-e3pazjdi 206 58 as as IN cord-252725-e3pazjdi 206 59 tomato tomato NN cord-252725-e3pazjdi 206 60 and and CC cord-252725-e3pazjdi 206 61 carrot carrot NN cord-252725-e3pazjdi 206 62 , , , cord-252725-e3pazjdi 206 63 flax flax NN cord-252725-e3pazjdi 206 64 , , , cord-252725-e3pazjdi 206 65 beets beet NNS cord-252725-e3pazjdi 206 66 , , , cord-252725-e3pazjdi 206 67 broccoli broccoli NN cord-252725-e3pazjdi 206 68 and and CC cord-252725-e3pazjdi 206 69 sweet sweet JJ cord-252725-e3pazjdi 206 70 corn corn NN cord-252725-e3pazjdi 206 71 [ [ -LRB- cord-252725-e3pazjdi 206 72 142 142 CD cord-252725-e3pazjdi 206 73 , , , cord-252725-e3pazjdi 206 74 143 143 CD cord-252725-e3pazjdi 206 75 ] ] -RRB- cord-252725-e3pazjdi 206 76 . . . cord-252725-e3pazjdi 207 1 Ferulic ferulic NN cord-252725-e3pazjdi 207 2 acid acid NN cord-252725-e3pazjdi 207 3 is be VBZ cord-252725-e3pazjdi 207 4 rapidly rapidly RB cord-252725-e3pazjdi 207 5 absorbed absorb VBN cord-252725-e3pazjdi 207 6 into into IN cord-252725-e3pazjdi 207 7 the the DT cord-252725-e3pazjdi 207 8 body body NN cord-252725-e3pazjdi 207 9 and and CC cord-252725-e3pazjdi 207 10 stays stay VBZ cord-252725-e3pazjdi 207 11 in in IN cord-252725-e3pazjdi 207 12 the the DT cord-252725-e3pazjdi 207 13 blood blood NN cord-252725-e3pazjdi 207 14 stream stream NN cord-252725-e3pazjdi 207 15 longer long RBR cord-252725-e3pazjdi 207 16 than than IN cord-252725-e3pazjdi 207 17 any any DT cord-252725-e3pazjdi 207 18 other other JJ cord-252725-e3pazjdi 207 19 antioxidant antioxidant NN cord-252725-e3pazjdi 207 20 , , , cord-252725-e3pazjdi 207 21 even even RB cord-252725-e3pazjdi 207 22 longer long RBR cord-252725-e3pazjdi 207 23 than than IN cord-252725-e3pazjdi 207 24 vitamin vitamin NN cord-252725-e3pazjdi 207 25 C. c. NN cord-252725-e3pazjdi 208 1 Because because IN cord-252725-e3pazjdi 208 2 of of IN cord-252725-e3pazjdi 208 3 these these DT cord-252725-e3pazjdi 208 4 features feature NNS cord-252725-e3pazjdi 208 5 , , , cord-252725-e3pazjdi 208 6 ferulic ferulic NN cord-252725-e3pazjdi 208 7 acid acid NN cord-252725-e3pazjdi 208 8 is be VBZ cord-252725-e3pazjdi 208 9 considered consider VBN cord-252725-e3pazjdi 208 10 to to TO cord-252725-e3pazjdi 208 11 be be VB cord-252725-e3pazjdi 208 12 a a DT cord-252725-e3pazjdi 208 13 superior superior JJ cord-252725-e3pazjdi 208 14 antioxidant antioxidant NN cord-252725-e3pazjdi 208 15 and and CC cord-252725-e3pazjdi 208 16 therefore therefore RB cord-252725-e3pazjdi 208 17 it -PRON- PRP cord-252725-e3pazjdi 208 18 is be VBZ cord-252725-e3pazjdi 208 19 widely widely RB cord-252725-e3pazjdi 208 20 used use VBN cord-252725-e3pazjdi 208 21 in in IN cord-252725-e3pazjdi 208 22 health health NN cord-252725-e3pazjdi 208 23 foods food NNS cord-252725-e3pazjdi 208 24 and and CC cord-252725-e3pazjdi 208 25 nutrition nutrition NN cord-252725-e3pazjdi 208 26 [ [ -LRB- cord-252725-e3pazjdi 208 27 144 144 CD cord-252725-e3pazjdi 208 28 ] ] -RRB- cord-252725-e3pazjdi 208 29 . . . cord-252725-e3pazjdi 209 1 In in IN cord-252725-e3pazjdi 209 2 addition addition NN cord-252725-e3pazjdi 209 3 , , , cord-252725-e3pazjdi 209 4 ferulic ferulic NN cord-252725-e3pazjdi 209 5 acid acid NN cord-252725-e3pazjdi 209 6 possesses possess VBZ cord-252725-e3pazjdi 209 7 many many JJ cord-252725-e3pazjdi 209 8 physiological physiological JJ cord-252725-e3pazjdi 209 9 activities activity NNS cord-252725-e3pazjdi 209 10 such such JJ cord-252725-e3pazjdi 209 11 as as IN cord-252725-e3pazjdi 209 12 anti anti JJ cord-252725-e3pazjdi 209 13 - - JJ cord-252725-e3pazjdi 209 14 inflammatory inflammatory JJ cord-252725-e3pazjdi 209 15 , , , cord-252725-e3pazjdi 209 16 antimicrobial antimicrobial JJ cord-252725-e3pazjdi 209 17 , , , cord-252725-e3pazjdi 209 18 antiviral antiviral JJ cord-252725-e3pazjdi 209 19 , , , cord-252725-e3pazjdi 209 20 anticancer anticancer JJ cord-252725-e3pazjdi 209 21 , , , cord-252725-e3pazjdi 209 22 antiarrhythmic antiarrhythmic JJ cord-252725-e3pazjdi 209 23 , , , cord-252725-e3pazjdi 209 24 antithrombotic antithrombotic JJ cord-252725-e3pazjdi 209 25 , , , cord-252725-e3pazjdi 209 26 antidiabetic antidiabetic JJ cord-252725-e3pazjdi 209 27 , , , cord-252725-e3pazjdi 209 28 lipid lipid NN cord-252725-e3pazjdi 209 29 peroxidation peroxidation NN cord-252725-e3pazjdi 209 30 prevention prevention NN cord-252725-e3pazjdi 209 31 , , , cord-252725-e3pazjdi 209 32 free free JJ cord-252725-e3pazjdi 209 33 radical radical JJ cord-252725-e3pazjdi 209 34 scavenger scavenger NN cord-252725-e3pazjdi 209 35 ; ; : cord-252725-e3pazjdi 209 36 increase increase VB cord-252725-e3pazjdi 209 37 NO no DT cord-252725-e3pazjdi 209 38 synthesis synthesis NN cord-252725-e3pazjdi 209 39 and and CC cord-252725-e3pazjdi 209 40 immunostimulant immunostimulant JJ cord-252725-e3pazjdi 209 41 properties property NNS cord-252725-e3pazjdi 209 42 [ [ -LRB- cord-252725-e3pazjdi 209 43 142 142 CD cord-252725-e3pazjdi 209 44 ] ] -RRB- cord-252725-e3pazjdi 210 1 [ [ -LRB- cord-252725-e3pazjdi 210 2 143 143 CD cord-252725-e3pazjdi 210 3 ] ] -RRB- cord-252725-e3pazjdi 210 4 [ [ -LRB- cord-252725-e3pazjdi 210 5 144 144 CD cord-252725-e3pazjdi 210 6 ] ] -RRB- cord-252725-e3pazjdi 210 7 . . . cord-252725-e3pazjdi 211 1 Sodium sodium NN cord-252725-e3pazjdi 211 2 ferulate ferulate NN cord-252725-e3pazjdi 211 3 , , , cord-252725-e3pazjdi 211 4 the the DT cord-252725-e3pazjdi 211 5 sodium sodium NN cord-252725-e3pazjdi 211 6 salt salt NN cord-252725-e3pazjdi 211 7 of of IN cord-252725-e3pazjdi 211 8 ferulic ferulic NN cord-252725-e3pazjdi 211 9 acid acid NN cord-252725-e3pazjdi 211 10 , , , cord-252725-e3pazjdi 211 11 in in IN cord-252725-e3pazjdi 211 12 a a DT cord-252725-e3pazjdi 211 13 combination combination NN cord-252725-e3pazjdi 211 14 with with IN cord-252725-e3pazjdi 211 15 oxymatrine oxymatrine NNP cord-252725-e3pazjdi 211 16 had have VBD cord-252725-e3pazjdi 211 17 a a DT cord-252725-e3pazjdi 211 18 protective protective JJ cord-252725-e3pazjdi 211 19 effect effect NN cord-252725-e3pazjdi 211 20 on on IN cord-252725-e3pazjdi 211 21 LPS LPS NNP cord-252725-e3pazjdi 211 22 - - HYPH cord-252725-e3pazjdi 211 23 induced induce VBN cord-252725-e3pazjdi 211 24 acute acute JJ cord-252725-e3pazjdi 211 25 lung lung NN cord-252725-e3pazjdi 211 26 injury injury NN cord-252725-e3pazjdi 211 27 in in IN cord-252725-e3pazjdi 211 28 mice mice NN cord-252725-e3pazjdi 211 29 principally principally RB cord-252725-e3pazjdi 211 30 by by IN cord-252725-e3pazjdi 211 31 inhibiting inhibit VBG cord-252725-e3pazjdi 211 32 the the DT cord-252725-e3pazjdi 211 33 production production NN cord-252725-e3pazjdi 211 34 of of IN cord-252725-e3pazjdi 211 35 CRP CRP NNP cord-252725-e3pazjdi 211 36 and and CC cord-252725-e3pazjdi 211 37 TNF TNF NNP cord-252725-e3pazjdi 211 38 - - HYPH cord-252725-e3pazjdi 211 39 α α NNP cord-252725-e3pazjdi 211 40 , , , cord-252725-e3pazjdi 211 41 which which WDT cord-252725-e3pazjdi 211 42 inhibited inhibit VBD cord-252725-e3pazjdi 211 43 the the DT cord-252725-e3pazjdi 211 44 myeloperoxidase myeloperoxidase NN cord-252725-e3pazjdi 211 45 ( ( -LRB- cord-252725-e3pazjdi 211 46 MPO MPO NNP cord-252725-e3pazjdi 211 47 ) ) -RRB- cord-252725-e3pazjdi 211 48 activity activity NN cord-252725-e3pazjdi 211 49 in in IN cord-252725-e3pazjdi 211 50 lung lung NN cord-252725-e3pazjdi 211 51 homogenate homogenate NNP cord-252725-e3pazjdi 211 52 and and CC cord-252725-e3pazjdi 211 53 attenuated attenuated JJ cord-252725-e3pazjdi 211 54 inflammatory inflammatory JJ cord-252725-e3pazjdi 211 55 cell cell NN cord-252725-e3pazjdi 211 56 numbers number NNS cord-252725-e3pazjdi 211 57 and and CC cord-252725-e3pazjdi 211 58 protein protein NN cord-252725-e3pazjdi 211 59 concentration concentration NN cord-252725-e3pazjdi 211 60 in in IN cord-252725-e3pazjdi 211 61 the the DT cord-252725-e3pazjdi 211 62 bronchoalveolar bronchoalveolar NNP cord-252725-e3pazjdi 211 63 lavage lavage NN cord-252725-e3pazjdi 211 64 fluid fluid NN cord-252725-e3pazjdi 211 65 . . . cord-252725-e3pazjdi 212 1 Similarly similarly RB cord-252725-e3pazjdi 212 2 , , , cord-252725-e3pazjdi 212 3 sodium sodium NN cord-252725-e3pazjdi 212 4 ferulate ferulate NN cord-252725-e3pazjdi 212 5 protects protect VBZ cord-252725-e3pazjdi 212 6 against against IN cord-252725-e3pazjdi 212 7 influenza influenza NN cord-252725-e3pazjdi 212 8 virus virus NN cord-252725-e3pazjdi 212 9 infection infection NN cord-252725-e3pazjdi 212 10 through through IN cord-252725-e3pazjdi 212 11 activation activation NN cord-252725-e3pazjdi 212 12 of of IN cord-252725-e3pazjdi 212 13 the the DT cord-252725-e3pazjdi 212 14 TLR7/9-MyD88-IRF7 TLR7/9-MyD88-IRF7 NNP cord-252725-e3pazjdi 212 15 pathway pathway NN cord-252725-e3pazjdi 212 16 , , , cord-252725-e3pazjdi 212 17 which which WDT cord-252725-e3pazjdi 212 18 recognizes recognize VBZ cord-252725-e3pazjdi 212 19 viral viral JJ cord-252725-e3pazjdi 212 20 nucleic nucleic JJ cord-252725-e3pazjdi 212 21 acids acid NNS cord-252725-e3pazjdi 212 22 and and CC cord-252725-e3pazjdi 212 23 activates activate VBZ cord-252725-e3pazjdi 212 24 different different JJ cord-252725-e3pazjdi 212 25 cascades cascade NNS cord-252725-e3pazjdi 212 26 that that WDT cord-252725-e3pazjdi 212 27 contribute contribute VBP cord-252725-e3pazjdi 212 28 to to IN cord-252725-e3pazjdi 212 29 the the DT cord-252725-e3pazjdi 212 30 production production NN cord-252725-e3pazjdi 212 31 of of IN cord-252725-e3pazjdi 212 32 interferons interferon NNS cord-252725-e3pazjdi 212 33 ( ( -LRB- cord-252725-e3pazjdi 212 34 IFNs ifn NNS cord-252725-e3pazjdi 212 35 ) ) -RRB- cord-252725-e3pazjdi 212 36 and and CC cord-252725-e3pazjdi 212 37 also also RB cord-252725-e3pazjdi 212 38 by by IN cord-252725-e3pazjdi 212 39 inhibiting inhibit VBG cord-252725-e3pazjdi 212 40 the the DT cord-252725-e3pazjdi 212 41 NF nf NN cord-252725-e3pazjdi 212 42 - - HYPH cord-252725-e3pazjdi 212 43 κB κB NNP cord-252725-e3pazjdi 212 44 pathway pathway NN cord-252725-e3pazjdi 212 45 , , , cord-252725-e3pazjdi 212 46 which which WDT cord-252725-e3pazjdi 212 47 resulted result VBD cord-252725-e3pazjdi 212 48 in in IN cord-252725-e3pazjdi 212 49 blocking block VBG cord-252725-e3pazjdi 212 50 the the DT cord-252725-e3pazjdi 212 51 influenza influenza NN cord-252725-e3pazjdi 212 52 virus virus NN cord-252725-e3pazjdi 212 53 replication replication NN cord-252725-e3pazjdi 212 54 [ [ -LRB- cord-252725-e3pazjdi 212 55 145 145 CD cord-252725-e3pazjdi 212 56 , , , cord-252725-e3pazjdi 212 57 146 146 CD cord-252725-e3pazjdi 212 58 ] ] -RRB- cord-252725-e3pazjdi 212 59 . . . cord-252725-e3pazjdi 213 1 Moreover moreover RB cord-252725-e3pazjdi 213 2 , , , cord-252725-e3pazjdi 213 3 a a DT cord-252725-e3pazjdi 213 4 ferulic ferulic NN cord-252725-e3pazjdi 213 5 acid acid NN cord-252725-e3pazjdi 213 6 derivative derivative NN cord-252725-e3pazjdi 213 7 had have VBD cord-252725-e3pazjdi 213 8 the the DT cord-252725-e3pazjdi 213 9 best good JJS cord-252725-e3pazjdi 213 10 inhibition inhibition NN cord-252725-e3pazjdi 213 11 activity activity NN cord-252725-e3pazjdi 213 12 against against IN cord-252725-e3pazjdi 213 13 the the DT cord-252725-e3pazjdi 213 14 neuraminidase neuraminidase NN cord-252725-e3pazjdi 213 15 ( ( -LRB- cord-252725-e3pazjdi 213 16 NA NA NNP cord-252725-e3pazjdi 213 17 ) ) -RRB- cord-252725-e3pazjdi 213 18 influenza influenza NN cord-252725-e3pazjdi 213 19 virus virus NN cord-252725-e3pazjdi 213 20 ( ( -LRB- cord-252725-e3pazjdi 213 21 H1N1 H1N1 NNP cord-252725-e3pazjdi 213 22 ) ) -RRB- cord-252725-e3pazjdi 213 23 , , , cord-252725-e3pazjdi 213 24 in in IN cord-252725-e3pazjdi 213 25 vitro vitro FW cord-252725-e3pazjdi 213 26 , , , cord-252725-e3pazjdi 213 27 due due IN cord-252725-e3pazjdi 213 28 to to IN cord-252725-e3pazjdi 213 29 the the DT cord-252725-e3pazjdi 213 30 interactions interaction NNS cord-252725-e3pazjdi 213 31 with with IN cord-252725-e3pazjdi 213 32 conserved conserved JJ cord-252725-e3pazjdi 213 33 and and CC cord-252725-e3pazjdi 213 34 essential essential JJ cord-252725-e3pazjdi 213 35 residues residue NNS cord-252725-e3pazjdi 213 36 of of IN cord-252725-e3pazjdi 213 37 NA NA NNP cord-252725-e3pazjdi 213 38 , , , cord-252725-e3pazjdi 213 39 which which WDT cord-252725-e3pazjdi 213 40 is be VBZ cord-252725-e3pazjdi 213 41 comparable comparable JJ cord-252725-e3pazjdi 213 42 to to IN cord-252725-e3pazjdi 213 43 those those DT cord-252725-e3pazjdi 213 44 of of IN cord-252725-e3pazjdi 213 45 oseltamivir oseltamivir NNP cord-252725-e3pazjdi 213 46 and and CC cord-252725-e3pazjdi 213 47 zanamivir zanamivir NNP cord-252725-e3pazjdi 213 48 , , , cord-252725-e3pazjdi 213 49 two two CD cord-252725-e3pazjdi 213 50 available available JJ cord-252725-e3pazjdi 213 51 commercial commercial JJ cord-252725-e3pazjdi 213 52 NA NA NNP cord-252725-e3pazjdi 213 53 inhibitors inhibitor NNS cord-252725-e3pazjdi 213 54 [ [ -LRB- cord-252725-e3pazjdi 213 55 147 147 CD cord-252725-e3pazjdi 213 56 ] ] -RRB- cord-252725-e3pazjdi 213 57 . . . cord-252725-e3pazjdi 214 1 The the DT cord-252725-e3pazjdi 214 2 presented present VBN cord-252725-e3pazjdi 214 3 properties property NNS cord-252725-e3pazjdi 214 4 of of IN cord-252725-e3pazjdi 214 5 ferulic ferulic NN cord-252725-e3pazjdi 214 6 acid acid NN cord-252725-e3pazjdi 214 7 and and CC cord-252725-e3pazjdi 214 8 its -PRON- PRP$ cord-252725-e3pazjdi 214 9 derivatives derivative NNS cord-252725-e3pazjdi 214 10 sodium sodium NN cord-252725-e3pazjdi 214 11 ferulate ferulate NN cord-252725-e3pazjdi 214 12 solely solely RB cord-252725-e3pazjdi 214 13 or or CC cord-252725-e3pazjdi 214 14 in in IN cord-252725-e3pazjdi 214 15 a a DT cord-252725-e3pazjdi 214 16 combination combination NN cord-252725-e3pazjdi 214 17 with with IN cord-252725-e3pazjdi 214 18 other other JJ cord-252725-e3pazjdi 214 19 compounds compound NNS cord-252725-e3pazjdi 214 20 may may MD cord-252725-e3pazjdi 214 21 warrant warrant VB cord-252725-e3pazjdi 214 22 their -PRON- PRP$ cord-252725-e3pazjdi 214 23 use use NN cord-252725-e3pazjdi 214 24 in in IN cord-252725-e3pazjdi 214 25 the the DT cord-252725-e3pazjdi 214 26 fight fight NN cord-252725-e3pazjdi 214 27 against against IN cord-252725-e3pazjdi 214 28 such such JJ cord-252725-e3pazjdi 214 29 emergence emergence NN cord-252725-e3pazjdi 214 30 disease disease NN cord-252725-e3pazjdi 214 31 similar similar JJ cord-252725-e3pazjdi 214 32 to to IN cord-252725-e3pazjdi 214 33 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 214 34 . . . cord-252725-e3pazjdi 215 1 Hesperetin Hesperetin NNP cord-252725-e3pazjdi 215 2 ( ( -LRB- cord-252725-e3pazjdi 215 3 3′,5,7-trihydroxy-4′-methoxyflavanone 3′,5,7-trihydroxy-4′-methoxyflavanone CD cord-252725-e3pazjdi 215 4 ) ) -RRB- cord-252725-e3pazjdi 216 1 ( ( -LRB- cord-252725-e3pazjdi 216 2 Fig Fig NNP cord-252725-e3pazjdi 216 3 . . . cord-252725-e3pazjdi 217 1 15 15 LS cord-252725-e3pazjdi 217 2 ) ) -RRB- cord-252725-e3pazjdi 217 3 a a DT cord-252725-e3pazjdi 217 4 naturally naturally RB cord-252725-e3pazjdi 217 5 occurring occur VBG cord-252725-e3pazjdi 217 6 flavone flavone NN cord-252725-e3pazjdi 217 7 is be VBZ cord-252725-e3pazjdi 217 8 found find VBN cord-252725-e3pazjdi 217 9 predominantly predominantly RB cord-252725-e3pazjdi 217 10 in in IN cord-252725-e3pazjdi 217 11 citrus citrus JJ cord-252725-e3pazjdi 217 12 fruits fruit NNS cord-252725-e3pazjdi 217 13 , , , cord-252725-e3pazjdi 217 14 lemons lemon NNS cord-252725-e3pazjdi 217 15 , , , cord-252725-e3pazjdi 217 16 sweet sweet JJ cord-252725-e3pazjdi 217 17 oranges orange NNS cord-252725-e3pazjdi 217 18 , , , cord-252725-e3pazjdi 217 19 bitter bitter JJ cord-252725-e3pazjdi 217 20 orange orange NN cord-252725-e3pazjdi 217 21 , , , cord-252725-e3pazjdi 217 22 and and CC cord-252725-e3pazjdi 217 23 grapefruit grapefruit NN cord-252725-e3pazjdi 217 24 juices juice NNS cord-252725-e3pazjdi 217 25 . . . cord-252725-e3pazjdi 218 1 In in IN cord-252725-e3pazjdi 218 2 addition addition NN cord-252725-e3pazjdi 218 3 , , , cord-252725-e3pazjdi 218 4 it -PRON- PRP cord-252725-e3pazjdi 218 5 occurs occur VBZ cord-252725-e3pazjdi 218 6 in in IN cord-252725-e3pazjdi 218 7 a a DT cord-252725-e3pazjdi 218 8 large large JJ cord-252725-e3pazjdi 218 9 number number NN cord-252725-e3pazjdi 218 10 of of IN cord-252725-e3pazjdi 218 11 fruits fruit NNS cord-252725-e3pazjdi 218 12 and and CC cord-252725-e3pazjdi 218 13 vegetables vegetable NNS cord-252725-e3pazjdi 218 14 such such JJ cord-252725-e3pazjdi 218 15 as as IN cord-252725-e3pazjdi 218 16 tomatoes tomato NNS cord-252725-e3pazjdi 218 17 and and CC cord-252725-e3pazjdi 218 18 cherries cherry NNS cord-252725-e3pazjdi 218 19 , , , cord-252725-e3pazjdi 218 20 and and CC cord-252725-e3pazjdi 218 21 various various JJ cord-252725-e3pazjdi 218 22 herbal herbal JJ cord-252725-e3pazjdi 218 23 formulations formulation NNS cord-252725-e3pazjdi 218 24 [ [ -LRB- cord-252725-e3pazjdi 218 25 148 148 CD cord-252725-e3pazjdi 218 26 ] ] -RRB- cord-252725-e3pazjdi 218 27 . . . cord-252725-e3pazjdi 219 1 Hesperetin Hesperetin NNP cord-252725-e3pazjdi 219 2 and and CC cord-252725-e3pazjdi 219 3 its -PRON- PRP$ cord-252725-e3pazjdi 219 4 metabolites metabolite NNS cord-252725-e3pazjdi 219 5 display display VBP cord-252725-e3pazjdi 219 6 several several JJ cord-252725-e3pazjdi 219 7 biological biological JJ cord-252725-e3pazjdi 219 8 activities activity NNS cord-252725-e3pazjdi 219 9 including include VBG cord-252725-e3pazjdi 219 10 antioxidant antioxidant JJ cord-252725-e3pazjdi 219 11 , , , cord-252725-e3pazjdi 219 12 anti anti JJ cord-252725-e3pazjdi 219 13 - - JJ cord-252725-e3pazjdi 219 14 inflammatory inflammatory JJ cord-252725-e3pazjdi 219 15 , , , cord-252725-e3pazjdi 219 16 and and CC cord-252725-e3pazjdi 219 17 lipid lipid NN cord-252725-e3pazjdi 219 18 decreasing decreasing NN cord-252725-e3pazjdi 219 19 levels level NNS cord-252725-e3pazjdi 219 20 , , , cord-252725-e3pazjdi 219 21 anticarcinogenic anticarcinogenic NNP cord-252725-e3pazjdi 219 22 , , , cord-252725-e3pazjdi 219 23 antidiabetic antidiabetic NNP cord-252725-e3pazjdi 219 24 , , , cord-252725-e3pazjdi 219 25 immunoregulatory immunoregulatory NNP cord-252725-e3pazjdi 219 26 , , , cord-252725-e3pazjdi 219 27 and and CC cord-252725-e3pazjdi 219 28 neuroprotective neuroprotective JJ cord-252725-e3pazjdi 219 29 [ [ -LRB- cord-252725-e3pazjdi 219 30 149 149 CD cord-252725-e3pazjdi 219 31 , , , cord-252725-e3pazjdi 219 32 150 150 CD cord-252725-e3pazjdi 219 33 ] ] -RRB- cord-252725-e3pazjdi 219 34 . . . cord-252725-e3pazjdi 220 1 Actually actually RB cord-252725-e3pazjdi 220 2 , , , cord-252725-e3pazjdi 220 3 several several JJ cord-252725-e3pazjdi 220 4 in in IN cord-252725-e3pazjdi 220 5 vitro vitro FW cord-252725-e3pazjdi 220 6 and and CC cord-252725-e3pazjdi 220 7 in in IN cord-252725-e3pazjdi 220 8 vivo vivo NNP cord-252725-e3pazjdi 220 9 studies study NNS cord-252725-e3pazjdi 220 10 have have VBP cord-252725-e3pazjdi 220 11 been be VBN cord-252725-e3pazjdi 220 12 reported report VBN cord-252725-e3pazjdi 220 13 that that IN cord-252725-e3pazjdi 220 14 Hesperetin Hesperetin NNP cord-252725-e3pazjdi 220 15 , , , cord-252725-e3pazjdi 220 16 its -PRON- PRP$ cord-252725-e3pazjdi 220 17 metabolites metabolite NNS cord-252725-e3pazjdi 220 18 , , , cord-252725-e3pazjdi 220 19 and and CC cord-252725-e3pazjdi 220 20 its -PRON- PRP$ cord-252725-e3pazjdi 220 21 synthetic synthetic JJ cord-252725-e3pazjdi 220 22 derivatives derivative NNS cord-252725-e3pazjdi 220 23 augmented augment VBD cord-252725-e3pazjdi 220 24 the the DT cord-252725-e3pazjdi 220 25 antioxidant antioxidant JJ cord-252725-e3pazjdi 220 26 cellular cellular JJ cord-252725-e3pazjdi 220 27 defenses defense NNS cord-252725-e3pazjdi 220 28 such such JJ cord-252725-e3pazjdi 220 29 as as IN cord-252725-e3pazjdi 220 30 the the DT cord-252725-e3pazjdi 220 31 ERK ERK NNP cord-252725-e3pazjdi 220 32 / / SYM cord-252725-e3pazjdi 220 33 Nrf2 Nrf2 NNP cord-252725-e3pazjdi 220 34 signaling signal VBG cord-252725-e3pazjdi 220 35 pathway pathway NN cord-252725-e3pazjdi 220 36 and and CC cord-252725-e3pazjdi 220 37 peroxisome peroxisome NN cord-252725-e3pazjdi 220 38 proliferatoractivated proliferatoractivated JJ cord-252725-e3pazjdi 220 39 receptor receptor NN cord-252725-e3pazjdi 220 40 - - HYPH cord-252725-e3pazjdi 220 41 γ γ NN cord-252725-e3pazjdi 220 42 ( ( -LRB- cord-252725-e3pazjdi 220 43 PPAR PPAR NNP cord-252725-e3pazjdi 220 44 - - HYPH cord-252725-e3pazjdi 220 45 γ γ NNP cord-252725-e3pazjdi 220 46 ) ) -RRB- cord-252725-e3pazjdi 220 47 , , , cord-252725-e3pazjdi 220 48 reduced reduce VBD cord-252725-e3pazjdi 220 49 inflammatory inflammatory JJ cord-252725-e3pazjdi 220 50 targets target NNS cord-252725-e3pazjdi 220 51 including include VBG cord-252725-e3pazjdi 220 52 NF nf NN cord-252725-e3pazjdi 220 53 - - HYPH cord-252725-e3pazjdi 220 54 κB κB NNP cord-252725-e3pazjdi 220 55 , , , cord-252725-e3pazjdi 220 56 iNOS inos CD cord-252725-e3pazjdi 220 57 , , , cord-252725-e3pazjdi 220 58 and and CC cord-252725-e3pazjdi 220 59 COX-2 COX-2 NNP cord-252725-e3pazjdi 220 60 , , , cord-252725-e3pazjdi 220 61 and and CC cord-252725-e3pazjdi 220 62 other other JJ cord-252725-e3pazjdi 220 63 markers marker NNS cord-252725-e3pazjdi 220 64 of of IN cord-252725-e3pazjdi 220 65 chronic chronic JJ cord-252725-e3pazjdi 220 66 inflammation inflammation NN cord-252725-e3pazjdi 220 67 such such JJ cord-252725-e3pazjdi 220 68 as as IN cord-252725-e3pazjdi 220 69 IL-1β IL-1β NNP cord-252725-e3pazjdi 220 70 , , , cord-252725-e3pazjdi 220 71 IL-6 IL-6 NNP cord-252725-e3pazjdi 220 72 , , , cord-252725-e3pazjdi 220 73 NO NO NNP cord-252725-e3pazjdi 220 74 and and CC cord-252725-e3pazjdi 220 75 TNF TNF NNP cord-252725-e3pazjdi 220 76 - - HYPH cord-252725-e3pazjdi 220 77 α α NNP cord-252725-e3pazjdi 220 78 [ [ -LRB- cord-252725-e3pazjdi 220 79 151 151 CD cord-252725-e3pazjdi 220 80 ] ] -RRB- cord-252725-e3pazjdi 220 81 [ [ -LRB- cord-252725-e3pazjdi 220 82 152 152 CD cord-252725-e3pazjdi 220 83 ] ] -RRB- cord-252725-e3pazjdi 220 84 [ [ -LRB- cord-252725-e3pazjdi 220 85 153 153 CD cord-252725-e3pazjdi 220 86 ] ] -RRB- cord-252725-e3pazjdi 220 87 . . . cord-252725-e3pazjdi 221 1 Hesperetin Hesperetin NNP cord-252725-e3pazjdi 221 2 has have VBZ cord-252725-e3pazjdi 221 3 been be VBN cord-252725-e3pazjdi 221 4 shown show VBN cord-252725-e3pazjdi 221 5 a a DT cord-252725-e3pazjdi 221 6 potential potential JJ cord-252725-e3pazjdi 221 7 drug drug NN cord-252725-e3pazjdi 221 8 for for IN cord-252725-e3pazjdi 221 9 acute acute JJ cord-252725-e3pazjdi 221 10 lung lung NN cord-252725-e3pazjdi 221 11 injury injury NN cord-252725-e3pazjdi 221 12 ( ( -LRB- cord-252725-e3pazjdi 221 13 ALI ALI NNP cord-252725-e3pazjdi 221 14 ) ) -RRB- cord-252725-e3pazjdi 221 15 induced induce VBN cord-252725-e3pazjdi 221 16 in in IN cord-252725-e3pazjdi 221 17 vivo vivo NN cord-252725-e3pazjdi 221 18 by by IN cord-252725-e3pazjdi 221 19 lipopolysaccharide lipopolysaccharide NN cord-252725-e3pazjdi 221 20 by by IN cord-252725-e3pazjdi 221 21 downregulated downregulate VBD cord-252725-e3pazjdi 221 22 the the DT cord-252725-e3pazjdi 221 23 Toll Toll NNP cord-252725-e3pazjdi 221 24 - - HYPH cord-252725-e3pazjdi 221 25 like like JJ cord-252725-e3pazjdi 221 26 receptor receptor NN cord-252725-e3pazjdi 221 27 4 4 CD cord-252725-e3pazjdi 221 28 ( ( -LRB- cord-252725-e3pazjdi 221 29 TLR4 TLR4 NNP cord-252725-e3pazjdi 221 30 ) ) -RRB- cord-252725-e3pazjdi 221 31 and and CC cord-252725-e3pazjdi 221 32 suppressed suppress VBD cord-252725-e3pazjdi 221 33 NF nf NN cord-252725-e3pazjdi 221 34 - - HYPH cord-252725-e3pazjdi 221 35 κB κb CD cord-252725-e3pazjdi 221 36 activation activation NN cord-252725-e3pazjdi 221 37 in in IN cord-252725-e3pazjdi 221 38 lung lung NN cord-252725-e3pazjdi 221 39 tissue tissue NN cord-252725-e3pazjdi 221 40 [ [ -LRB- cord-252725-e3pazjdi 221 41 154 154 CD cord-252725-e3pazjdi 221 42 ] ] -RRB- cord-252725-e3pazjdi 221 43 . . . cord-252725-e3pazjdi 222 1 Hespertein Hespertein NNP cord-252725-e3pazjdi 222 2 plus plus IN cord-252725-e3pazjdi 222 3 naringenin naringenin NNP cord-252725-e3pazjdi 222 4 has have VBZ cord-252725-e3pazjdi 222 5 a a DT cord-252725-e3pazjdi 222 6 protective protective JJ cord-252725-e3pazjdi 222 7 capacity capacity NN cord-252725-e3pazjdi 222 8 against against IN cord-252725-e3pazjdi 222 9 lung lung NN cord-252725-e3pazjdi 222 10 fibrosis fibrosis NN cord-252725-e3pazjdi 222 11 by by IN cord-252725-e3pazjdi 222 12 reducing reduce VBG cord-252725-e3pazjdi 222 13 airway airway NN cord-252725-e3pazjdi 222 14 inflammation inflammation NN cord-252725-e3pazjdi 222 15 in in IN cord-252725-e3pazjdi 222 16 murine murine JJ cord-252725-e3pazjdi 222 17 chronic chronic JJ cord-252725-e3pazjdi 222 18 asthma asthma NN cord-252725-e3pazjdi 222 19 model model NN cord-252725-e3pazjdi 222 20 . . . cord-252725-e3pazjdi 223 1 In in IN cord-252725-e3pazjdi 223 2 addition addition NN cord-252725-e3pazjdi 223 3 , , , cord-252725-e3pazjdi 223 4 the the DT cord-252725-e3pazjdi 223 5 anti anti JJ cord-252725-e3pazjdi 223 6 - - JJ cord-252725-e3pazjdi 223 7 fibrotic fibrotic JJ cord-252725-e3pazjdi 223 8 effects effect NNS cord-252725-e3pazjdi 223 9 of of IN cord-252725-e3pazjdi 223 10 hespertein hespertein NNP cord-252725-e3pazjdi 223 11 have have VBP cord-252725-e3pazjdi 223 12 been be VBN cord-252725-e3pazjdi 223 13 indicated indicate VBN cord-252725-e3pazjdi 223 14 in in IN cord-252725-e3pazjdi 223 15 the the DT cord-252725-e3pazjdi 223 16 liver liver NN cord-252725-e3pazjdi 223 17 and and CC cord-252725-e3pazjdi 223 18 kidney kidney NN cord-252725-e3pazjdi 223 19 [ [ -LRB- cord-252725-e3pazjdi 223 20 155 155 CD cord-252725-e3pazjdi 223 21 , , , cord-252725-e3pazjdi 223 22 156 156 CD cord-252725-e3pazjdi 223 23 ] ] -RRB- cord-252725-e3pazjdi 223 24 . . . cord-252725-e3pazjdi 224 1 Hespertin Hespertin NNP cord-252725-e3pazjdi 224 2 exerted exert VBD cord-252725-e3pazjdi 224 3 inhibitory inhibitory JJ cord-252725-e3pazjdi 224 4 effect effect NN cord-252725-e3pazjdi 224 5 on on IN cord-252725-e3pazjdi 224 6 the the DT cord-252725-e3pazjdi 224 7 intracellular intracellular JJ cord-252725-e3pazjdi 224 8 replication replication NN cord-252725-e3pazjdi 224 9 of of IN cord-252725-e3pazjdi 224 10 transmitted transmit VBN cord-252725-e3pazjdi 224 11 Chikungunya chikungunya NN cord-252725-e3pazjdi 224 12 virus virus NN cord-252725-e3pazjdi 224 13 ( ( -LRB- cord-252725-e3pazjdi 224 14 CHIKV CHIKV NNP cord-252725-e3pazjdi 224 15 ) ) -RRB- cord-252725-e3pazjdi 224 16 and and CC cord-252725-e3pazjdi 224 17 exhibits exhibit VBZ cord-252725-e3pazjdi 224 18 drug drug NN cord-252725-e3pazjdi 224 19 - - HYPH cord-252725-e3pazjdi 224 20 like like JJ cord-252725-e3pazjdi 224 21 properties property NNS cord-252725-e3pazjdi 224 22 which which WDT cord-252725-e3pazjdi 224 23 maybe maybe RB cord-252725-e3pazjdi 224 24 a a DT cord-252725-e3pazjdi 224 25 potential potential NN cord-252725-e3pazjdi 224 26 as as IN cord-252725-e3pazjdi 224 27 a a DT cord-252725-e3pazjdi 224 28 therapeutic therapeutic JJ cord-252725-e3pazjdi 224 29 option option NN cord-252725-e3pazjdi 224 30 for for IN cord-252725-e3pazjdi 224 31 CHIKV CHIKV NNP cord-252725-e3pazjdi 224 32 infection infection NN cord-252725-e3pazjdi 224 33 [ [ -LRB- cord-252725-e3pazjdi 224 34 157 157 CD cord-252725-e3pazjdi 224 35 ] ] -RRB- cord-252725-e3pazjdi 224 36 . . . cord-252725-e3pazjdi 225 1 Moreover moreover RB cord-252725-e3pazjdi 225 2 , , , cord-252725-e3pazjdi 225 3 hesperetin hesperetin NNP cord-252725-e3pazjdi 225 4 has have VBZ cord-252725-e3pazjdi 225 5 shown show VBN cord-252725-e3pazjdi 225 6 an an DT cord-252725-e3pazjdi 225 7 antiviral antiviral JJ cord-252725-e3pazjdi 225 8 activity activity NN cord-252725-e3pazjdi 225 9 against against IN cord-252725-e3pazjdi 225 10 the the DT cord-252725-e3pazjdi 225 11 human human JJ cord-252725-e3pazjdi 225 12 Respiratory Respiratory NNP cord-252725-e3pazjdi 225 13 Syncytial Syncytial NNP cord-252725-e3pazjdi 225 14 Virus Virus NNP cord-252725-e3pazjdi 225 15 ( ( -LRB- cord-252725-e3pazjdi 225 16 hRSV hRSV NNP cord-252725-e3pazjdi 225 17 ) ) -RRB- cord-252725-e3pazjdi 225 18 trough trough NN cord-252725-e3pazjdi 225 19 binding bind VBG cord-252725-e3pazjdi 225 20 to to IN cord-252725-e3pazjdi 225 21 M2 M2 NNP cord-252725-e3pazjdi 225 22 - - SYM cord-252725-e3pazjdi 225 23 1 1 CD cord-252725-e3pazjdi 225 24 virus virus NN cord-252725-e3pazjdi 225 25 protein protein NN cord-252725-e3pazjdi 225 26 , , , cord-252725-e3pazjdi 225 27 which which WDT cord-252725-e3pazjdi 225 28 is be VBZ cord-252725-e3pazjdi 225 29 an an DT cord-252725-e3pazjdi 225 30 important important JJ cord-252725-e3pazjdi 225 31 transcriptional transcriptional JJ cord-252725-e3pazjdi 225 32 anti anti JJ cord-252725-e3pazjdi 225 33 - - JJ cord-252725-e3pazjdi 225 34 termination termination JJ cord-252725-e3pazjdi 225 35 factor factor NN cord-252725-e3pazjdi 225 36 and and CC cord-252725-e3pazjdi 225 37 a a DT cord-252725-e3pazjdi 225 38 potential potential JJ cord-252725-e3pazjdi 225 39 target target NN cord-252725-e3pazjdi 225 40 for for IN cord-252725-e3pazjdi 225 41 viral viral JJ cord-252725-e3pazjdi 225 42 replication replication NN cord-252725-e3pazjdi 225 43 inhibitor inhibitor NN cord-252725-e3pazjdi 225 44 development development NN cord-252725-e3pazjdi 225 45 [ [ -LRB- cord-252725-e3pazjdi 225 46 158 158 CD cord-252725-e3pazjdi 225 47 ] ] -RRB- cord-252725-e3pazjdi 225 48 . . . cord-252725-e3pazjdi 226 1 Among among IN cord-252725-e3pazjdi 226 2 several several JJ cord-252725-e3pazjdi 226 3 compounds compound NNS cord-252725-e3pazjdi 226 4 that that WDT cord-252725-e3pazjdi 226 5 exhibit exhibit VBP cord-252725-e3pazjdi 226 6 an an DT cord-252725-e3pazjdi 226 7 in in IN cord-252725-e3pazjdi 226 8 vitro vitro FW cord-252725-e3pazjdi 226 9 activity activity NN cord-252725-e3pazjdi 226 10 against against IN cord-252725-e3pazjdi 226 11 SARS SARS NNP cord-252725-e3pazjdi 226 12 - - HYPH cord-252725-e3pazjdi 226 13 CoV CoV NNP cord-252725-e3pazjdi 226 14 , , , cord-252725-e3pazjdi 226 15 hesperetin hesperetin NNP cord-252725-e3pazjdi 226 16 , , , cord-252725-e3pazjdi 226 17 was be VBD cord-252725-e3pazjdi 226 18 the the DT cord-252725-e3pazjdi 226 19 most most RBS cord-252725-e3pazjdi 226 20 selective selective JJ cord-252725-e3pazjdi 226 21 with with IN cord-252725-e3pazjdi 226 22 a a DT cord-252725-e3pazjdi 226 23 selectivity selectivity NN cord-252725-e3pazjdi 226 24 index index NN cord-252725-e3pazjdi 226 25 of of IN cord-252725-e3pazjdi 226 26 ∼300 ∼300 NNP cord-252725-e3pazjdi 226 27 . . . cord-252725-e3pazjdi 227 1 Hesperetin Hesperetin NNP cord-252725-e3pazjdi 227 2 dose dose NN cord-252725-e3pazjdi 227 3 - - HYPH cord-252725-e3pazjdi 227 4 dependently dependently RB cord-252725-e3pazjdi 227 5 suppressed suppress VBD cord-252725-e3pazjdi 227 6 the the DT cord-252725-e3pazjdi 227 7 cleavage cleavage NN cord-252725-e3pazjdi 227 8 activity activity NN cord-252725-e3pazjdi 227 9 of of IN cord-252725-e3pazjdi 227 10 the the DT cord-252725-e3pazjdi 227 11 3C 3c NN cord-252725-e3pazjdi 227 12 - - HYPH cord-252725-e3pazjdi 227 13 like like JJ cord-252725-e3pazjdi 227 14 protease protease NN cord-252725-e3pazjdi 227 15 ( ( -LRB- cord-252725-e3pazjdi 227 16 3CLpro 3clpro CD cord-252725-e3pazjdi 227 17 ) ) -RRB- cord-252725-e3pazjdi 227 18 of of IN cord-252725-e3pazjdi 227 19 SARS SARS NNP cord-252725-e3pazjdi 227 20 - - HYPH cord-252725-e3pazjdi 227 21 CoV CoV NNP cord-252725-e3pazjdi 227 22 in in IN cord-252725-e3pazjdi 227 23 cell cell NN cord-252725-e3pazjdi 227 24 - - HYPH cord-252725-e3pazjdi 227 25 free free JJ cord-252725-e3pazjdi 227 26 and and CC cord-252725-e3pazjdi 227 27 cell cell NN cord-252725-e3pazjdi 227 28 - - HYPH cord-252725-e3pazjdi 227 29 based base VBN cord-252725-e3pazjdi 227 30 assays assay NNS cord-252725-e3pazjdi 227 31 [ [ -LRB- cord-252725-e3pazjdi 227 32 159 159 CD cord-252725-e3pazjdi 227 33 ] ] -RRB- cord-252725-e3pazjdi 227 34 . . . cord-252725-e3pazjdi 228 1 Furthermore furthermore RB cord-252725-e3pazjdi 228 2 , , , cord-252725-e3pazjdi 228 3 a a DT cord-252725-e3pazjdi 228 4 recent recent JJ cord-252725-e3pazjdi 228 5 study study NN cord-252725-e3pazjdi 228 6 has have VBZ cord-252725-e3pazjdi 228 7 reported report VBN cord-252725-e3pazjdi 228 8 that that IN cord-252725-e3pazjdi 228 9 hesperetin hesperetin NNP cord-252725-e3pazjdi 228 10 has have VBZ cord-252725-e3pazjdi 228 11 the the DT cord-252725-e3pazjdi 228 12 potential potential NN cord-252725-e3pazjdi 228 13 to to TO cord-252725-e3pazjdi 228 14 inhibit inhibit VB cord-252725-e3pazjdi 228 15 angiotensin angiotensin NN cord-252725-e3pazjdi 228 16 - - HYPH cord-252725-e3pazjdi 228 17 converting convert VBG cord-252725-e3pazjdi 228 18 enzyme enzyme NN cord-252725-e3pazjdi 228 19 2 2 CD cord-252725-e3pazjdi 228 20 ( ( -LRB- cord-252725-e3pazjdi 228 21 ACE2 ACE2 NNP cord-252725-e3pazjdi 228 22 ) ) -RRB- cord-252725-e3pazjdi 228 23 , , , cord-252725-e3pazjdi 228 24 the the DT cord-252725-e3pazjdi 228 25 same same JJ cord-252725-e3pazjdi 228 26 host host NN cord-252725-e3pazjdi 228 27 receptor receptor NN cord-252725-e3pazjdi 228 28 of of IN cord-252725-e3pazjdi 228 29 SARS SARS NNP cord-252725-e3pazjdi 228 30 - - HYPH cord-252725-e3pazjdi 228 31 CoV CoV NNP cord-252725-e3pazjdi 228 32 and and CC cord-252725-e3pazjdi 228 33 thus thus RB cord-252725-e3pazjdi 228 34 block block VB cord-252725-e3pazjdi 228 35 infection infection NN cord-252725-e3pazjdi 228 36 with with IN cord-252725-e3pazjdi 228 37 SARS SARS NNP cord-252725-e3pazjdi 228 38 - - HYPH cord-252725-e3pazjdi 228 39 CoV-2 CoV-2 NNP cord-252725-e3pazjdi 228 40 [ [ -LRB- cord-252725-e3pazjdi 228 41 160 160 CD cord-252725-e3pazjdi 228 42 ] ] -RRB- cord-252725-e3pazjdi 228 43 . . . cord-252725-e3pazjdi 229 1 Therefore therefore RB cord-252725-e3pazjdi 229 2 , , , cord-252725-e3pazjdi 229 3 these these DT cord-252725-e3pazjdi 229 4 studies study NNS cord-252725-e3pazjdi 229 5 clearly clearly RB cord-252725-e3pazjdi 229 6 suggest suggest VBP cord-252725-e3pazjdi 229 7 that that IN cord-252725-e3pazjdi 229 8 hesperetin hesperetin NNP cord-252725-e3pazjdi 229 9 could could MD cord-252725-e3pazjdi 229 10 play play VB cord-252725-e3pazjdi 229 11 a a DT cord-252725-e3pazjdi 229 12 key key JJ cord-252725-e3pazjdi 229 13 role role NN cord-252725-e3pazjdi 229 14 in in IN cord-252725-e3pazjdi 229 15 the the DT cord-252725-e3pazjdi 229 16 prevention prevention NN cord-252725-e3pazjdi 229 17 and and CC cord-252725-e3pazjdi 229 18 treatment treatment NN cord-252725-e3pazjdi 229 19 of of IN cord-252725-e3pazjdi 229 20 COVID-19 covid-19 JJ cord-252725-e3pazjdi 229 21 and and CC cord-252725-e3pazjdi 229 22 related related JJ cord-252725-e3pazjdi 229 23 pneumonia pneumonia NN cord-252725-e3pazjdi 229 24 . . . cord-252725-e3pazjdi 230 1 Vanillic Vanillic NNP cord-252725-e3pazjdi 230 2 acid acid NN cord-252725-e3pazjdi 230 3 ( ( -LRB- cord-252725-e3pazjdi 230 4 4-hydroxy-3-methoxybenzoicacid 4-hydroxy-3-methoxybenzoicacid CD cord-252725-e3pazjdi 230 5 ) ) -RRB- cord-252725-e3pazjdi 231 1 ( ( -LRB- cord-252725-e3pazjdi 231 2 Fig Fig NNP cord-252725-e3pazjdi 231 3 . . . cord-252725-e3pazjdi 232 1 16 16 CD cord-252725-e3pazjdi 232 2 ) ) -RRB- cord-252725-e3pazjdi 232 3 , , , cord-252725-e3pazjdi 232 4 an an DT cord-252725-e3pazjdi 232 5 intermediate intermediate JJ cord-252725-e3pazjdi 232 6 in in IN cord-252725-e3pazjdi 232 7 the the DT cord-252725-e3pazjdi 232 8 production production NN cord-252725-e3pazjdi 232 9 of of IN cord-252725-e3pazjdi 232 10 vanillin vanillin NN cord-252725-e3pazjdi 232 11 from from IN cord-252725-e3pazjdi 232 12 ferulic ferulic JJ cord-252725-e3pazjdi 232 13 acid acid NN cord-252725-e3pazjdi 232 14 is be VBZ cord-252725-e3pazjdi 232 15 the the DT cord-252725-e3pazjdi 232 16 main main JJ cord-252725-e3pazjdi 232 17 flavor flavor NN cord-252725-e3pazjdi 232 18 component component NN cord-252725-e3pazjdi 232 19 of of IN cord-252725-e3pazjdi 232 20 cured cure VBN cord-252725-e3pazjdi 232 21 vanilla vanilla NN cord-252725-e3pazjdi 232 22 beans bean NNS cord-252725-e3pazjdi 232 23 . . . cord-252725-e3pazjdi 233 1 Vanillic vanillic JJ cord-252725-e3pazjdi 233 2 acid acid NN cord-252725-e3pazjdi 233 3 is be VBZ cord-252725-e3pazjdi 233 4 found find VBN cord-252725-e3pazjdi 233 5 in in IN cord-252725-e3pazjdi 233 6 the the DT cord-252725-e3pazjdi 233 7 roots root NNS cord-252725-e3pazjdi 233 8 of of IN cord-252725-e3pazjdi 233 9 Angelica Angelica NNP cord-252725-e3pazjdi 233 10 sinensis sinensis NN cord-252725-e3pazjdi 233 11 , , , cord-252725-e3pazjdi 233 12 a a DT cord-252725-e3pazjdi 233 13 plant plant NN cord-252725-e3pazjdi 233 14 used use VBN cord-252725-e3pazjdi 233 15 in in IN cord-252725-e3pazjdi 233 16 traditional traditional JJ cord-252725-e3pazjdi 233 17 Chinese chinese JJ cord-252725-e3pazjdi 233 18 medicine medicine NN cord-252725-e3pazjdi 233 19 , , , cord-252725-e3pazjdi 233 20 açaí açaí NN cord-252725-e3pazjdi 233 21 oil oil NN cord-252725-e3pazjdi 233 22 , , , cord-252725-e3pazjdi 233 23 olive olive NN cord-252725-e3pazjdi 233 24 oil oil NN cord-252725-e3pazjdi 233 25 vinegar vinegar NN cord-252725-e3pazjdi 233 26 and and CC cord-252725-e3pazjdi 233 27 wine wine NN cord-252725-e3pazjdi 233 28 [ [ -LRB- cord-252725-e3pazjdi 233 29 161 161 CD cord-252725-e3pazjdi 233 30 , , , cord-252725-e3pazjdi 233 31 162 162 CD cord-252725-e3pazjdi 233 32 ] ] -RRB- cord-252725-e3pazjdi 233 33 . . . cord-252725-e3pazjdi 234 1 Vanillic vanillic JJ cord-252725-e3pazjdi 234 2 acid acid NN cord-252725-e3pazjdi 234 3 is be VBZ cord-252725-e3pazjdi 234 4 a a DT cord-252725-e3pazjdi 234 5 well well RB cord-252725-e3pazjdi 234 6 - - HYPH cord-252725-e3pazjdi 234 7 known know VBN cord-252725-e3pazjdi 234 8 generally generally RB cord-252725-e3pazjdi 234 9 regarded regard VBN cord-252725-e3pazjdi 234 10 as as IN cord-252725-e3pazjdi 234 11 a a DT cord-252725-e3pazjdi 234 12 safe safe JJ cord-252725-e3pazjdi 234 13 flavoring flavoring NN cord-252725-e3pazjdi 234 14 agent agent NN cord-252725-e3pazjdi 234 15 with with IN cord-252725-e3pazjdi 234 16 beneficial beneficial JJ cord-252725-e3pazjdi 234 17 biological biological JJ cord-252725-e3pazjdi 234 18 activities activity NNS cord-252725-e3pazjdi 234 19 such such JJ cord-252725-e3pazjdi 234 20 as as IN cord-252725-e3pazjdi 234 21 anti anti JJ cord-252725-e3pazjdi 234 22 - - JJ cord-252725-e3pazjdi 234 23 oxidant oxidant JJ cord-252725-e3pazjdi 234 24 , , , cord-252725-e3pazjdi 234 25 anti anti JJ cord-252725-e3pazjdi 234 26 - - JJ cord-252725-e3pazjdi 234 27 lipid lipid JJ cord-252725-e3pazjdi 234 28 peroxidative peroxidative NN cord-252725-e3pazjdi 234 29 , , , cord-252725-e3pazjdi 234 30 anti anti JJ cord-252725-e3pazjdi 234 31 - - JJ cord-252725-e3pazjdi 234 32 inflammatory inflammatory JJ cord-252725-e3pazjdi 234 33 , , , cord-252725-e3pazjdi 234 34 anti anti JJ cord-252725-e3pazjdi 234 35 - - JJ cord-252725-e3pazjdi 234 36 apoptosis apoptosis JJ cord-252725-e3pazjdi 234 37 , , , cord-252725-e3pazjdi 234 38 neuroprotective neuroprotective JJ cord-252725-e3pazjdi 234 39 / / SYM cord-252725-e3pazjdi 234 40 cognitive cognitive JJ cord-252725-e3pazjdi 234 41 and and CC cord-252725-e3pazjdi 234 42 regulation regulation NN cord-252725-e3pazjdi 234 43 of of IN cord-252725-e3pazjdi 234 44 insulin insulin NN cord-252725-e3pazjdi 234 45 secretion secretion NN cord-252725-e3pazjdi 234 46 [ [ -LRB- cord-252725-e3pazjdi 234 47 163 163 CD cord-252725-e3pazjdi 234 48 , , , cord-252725-e3pazjdi 234 49 164 164 CD cord-252725-e3pazjdi 234 50 ] ] -RRB- cord-252725-e3pazjdi 234 51 . . . cord-252725-e3pazjdi 235 1 Several several JJ cord-252725-e3pazjdi 235 2 studies study NNS cord-252725-e3pazjdi 235 3 have have VBP cord-252725-e3pazjdi 235 4 reported report VBN cord-252725-e3pazjdi 235 5 the the DT cord-252725-e3pazjdi 235 6 efficiency efficiency NN cord-252725-e3pazjdi 235 7 of of IN cord-252725-e3pazjdi 235 8 vanillic vanillic JJ cord-252725-e3pazjdi 235 9 acid acid NN cord-252725-e3pazjdi 235 10 in in IN cord-252725-e3pazjdi 235 11 controlling control VBG cord-252725-e3pazjdi 235 12 the the DT cord-252725-e3pazjdi 235 13 immune immune JJ cord-252725-e3pazjdi 235 14 response response NN cord-252725-e3pazjdi 235 15 or or CC cord-252725-e3pazjdi 235 16 the the DT cord-252725-e3pazjdi 235 17 inflammatory inflammatory JJ cord-252725-e3pazjdi 235 18 ones one NNS cord-252725-e3pazjdi 235 19 . . . cord-252725-e3pazjdi 236 1 Vanillic Vanillic NNP cord-252725-e3pazjdi 236 2 acid acid NN cord-252725-e3pazjdi 236 3 improved improve VBD cord-252725-e3pazjdi 236 4 the the DT cord-252725-e3pazjdi 236 5 activity activity NN cord-252725-e3pazjdi 236 6 of of IN cord-252725-e3pazjdi 236 7 human human JJ cord-252725-e3pazjdi 236 8 lymphocyte lymphocyte NN cord-252725-e3pazjdi 236 9 proliferation proliferation NN cord-252725-e3pazjdi 236 10 and and CC cord-252725-e3pazjdi 236 11 secretion secretion NN cord-252725-e3pazjdi 236 12 of of IN cord-252725-e3pazjdi 236 13 interferon interferon NN cord-252725-e3pazjdi 236 14 - - HYPH cord-252725-e3pazjdi 236 15 gamma gamma NN cord-252725-e3pazjdi 236 16 ( ( -LRB- cord-252725-e3pazjdi 236 17 INFγ INFγ NNP cord-252725-e3pazjdi 236 18 ) ) -RRB- cord-252725-e3pazjdi 236 19 in in IN cord-252725-e3pazjdi 236 20 human human JJ cord-252725-e3pazjdi 236 21 peripheral peripheral JJ cord-252725-e3pazjdi 236 22 blood blood NN cord-252725-e3pazjdi 236 23 mononuclear mononuclear NN cord-252725-e3pazjdi 236 24 cells cell NNS cord-252725-e3pazjdi 236 25 . . . cord-252725-e3pazjdi 237 1 Additional additional JJ cord-252725-e3pazjdi 237 2 study study NN cord-252725-e3pazjdi 237 3 indicated indicate VBD cord-252725-e3pazjdi 237 4 that that IN cord-252725-e3pazjdi 237 5 vanillic vanillic JJ cord-252725-e3pazjdi 237 6 acid acid NN cord-252725-e3pazjdi 237 7 has have VBZ cord-252725-e3pazjdi 237 8 a a DT cord-252725-e3pazjdi 237 9 hepatoprotective hepatoprotective JJ cord-252725-e3pazjdi 237 10 effect effect NN cord-252725-e3pazjdi 237 11 through through IN cord-252725-e3pazjdi 237 12 its -PRON- PRP$ cord-252725-e3pazjdi 237 13 suppressive suppressive JJ cord-252725-e3pazjdi 237 14 action action NN cord-252725-e3pazjdi 237 15 on on IN cord-252725-e3pazjdi 237 16 immune immune NN cord-252725-e3pazjdi 237 17 - - HYPH cord-252725-e3pazjdi 237 18 mediated mediate VBN cord-252725-e3pazjdi 237 19 liver liver NN cord-252725-e3pazjdi 237 20 inflammation inflammation NN cord-252725-e3pazjdi 237 21 in in IN cord-252725-e3pazjdi 237 22 concanavalin concanavalin NNP cord-252725-e3pazjdi 237 23 A A NNP cord-252725-e3pazjdi 237 24 - - HYPH cord-252725-e3pazjdi 237 25 induced induce VBN cord-252725-e3pazjdi 237 26 liver liver NN cord-252725-e3pazjdi 237 27 injury injury NN cord-252725-e3pazjdi 237 28 [ [ -LRB- cord-252725-e3pazjdi 237 29 165 165 CD cord-252725-e3pazjdi 237 30 , , , cord-252725-e3pazjdi 237 31 166 166 CD cord-252725-e3pazjdi 237 32 ] ] -RRB- cord-252725-e3pazjdi 237 33 . . . cord-252725-e3pazjdi 238 1 Vanillic Vanillic NNP cord-252725-e3pazjdi 238 2 acid acid NN cord-252725-e3pazjdi 238 3 was be VBD cord-252725-e3pazjdi 238 4 found find VBN cord-252725-e3pazjdi 238 5 to to TO cord-252725-e3pazjdi 238 6 inhibit inhibit VB cord-252725-e3pazjdi 238 7 inflammatory inflammatory JJ cord-252725-e3pazjdi 238 8 state state NN cord-252725-e3pazjdi 238 9 in in IN cord-252725-e3pazjdi 238 10 mice mouse NNS cord-252725-e3pazjdi 238 11 by by IN cord-252725-e3pazjdi 238 12 suppressing suppress VBG cord-252725-e3pazjdi 238 13 neutrophil neutrophil NN cord-252725-e3pazjdi 238 14 recruitment recruitment NN cord-252725-e3pazjdi 238 15 and and CC cord-252725-e3pazjdi 238 16 its -PRON- PRP$ cord-252725-e3pazjdi 238 17 mechanisms mechanism NNS cord-252725-e3pazjdi 238 18 of of IN cord-252725-e3pazjdi 238 19 action action NN cord-252725-e3pazjdi 238 20 involves involve VBZ cord-252725-e3pazjdi 238 21 antioxidant antioxidant JJ cord-252725-e3pazjdi 238 22 effects effect NNS cord-252725-e3pazjdi 238 23 and and CC cord-252725-e3pazjdi 238 24 NFκB nfκb NN cord-252725-e3pazjdi 238 25 - - HYPH cord-252725-e3pazjdi 238 26 related relate VBN cord-252725-e3pazjdi 238 27 inhibition inhibition NN cord-252725-e3pazjdi 238 28 of of IN cord-252725-e3pazjdi 238 29 pro pro JJ cord-252725-e3pazjdi 238 30 - - JJ cord-252725-e3pazjdi 238 31 inflammatory inflammatory JJ cord-252725-e3pazjdi 238 32 cytokine cytokine NN cord-252725-e3pazjdi 238 33 production production NN cord-252725-e3pazjdi 238 34 such such JJ cord-252725-e3pazjdi 238 35 as as IN cord-252725-e3pazjdi 238 36 IL6 IL6 NNP cord-252725-e3pazjdi 238 37 , , , cord-252725-e3pazjdi 238 38 COX2 COX2 NNP cord-252725-e3pazjdi 238 39 , , , cord-252725-e3pazjdi 238 40 IL-1β IL-1β NNP cord-252725-e3pazjdi 238 41 and and CC cord-252725-e3pazjdi 238 42 TNF TNF NNP cord-252725-e3pazjdi 238 43 - - HYPH cord-252725-e3pazjdi 238 44 α α NNP cord-252725-e3pazjdi 238 45 [ [ -LRB- cord-252725-e3pazjdi 238 46 167 167 CD cord-252725-e3pazjdi 238 47 , , , cord-252725-e3pazjdi 238 48 168 168 CD cord-252725-e3pazjdi 238 49 ] ] -RRB- cord-252725-e3pazjdi 238 50 . . . cord-252725-e3pazjdi 239 1 Moreover moreover RB cord-252725-e3pazjdi 239 2 , , , cord-252725-e3pazjdi 239 3 the the DT cord-252725-e3pazjdi 239 4 major major JJ cord-252725-e3pazjdi 239 5 compounds compound NNS cord-252725-e3pazjdi 239 6 extracted extract VBN cord-252725-e3pazjdi 239 7 from from IN cord-252725-e3pazjdi 239 8 the the DT cord-252725-e3pazjdi 239 9 root root NN cord-252725-e3pazjdi 239 10 of of IN cord-252725-e3pazjdi 239 11 Rubia Rubia NNP cord-252725-e3pazjdi 239 12 cordifolia cordifolia NNP cord-252725-e3pazjdi 239 13 ( ( -LRB- cord-252725-e3pazjdi 239 14 xanthopurpurin xanthopurpurin NNP cord-252725-e3pazjdi 239 15 and and CC cord-252725-e3pazjdi 239 16 vanillic vanillic JJ cord-252725-e3pazjdi 239 17 acid acid NNP cord-252725-e3pazjdi 239 18 ) ) -RRB- cord-252725-e3pazjdi 239 19 , , , cord-252725-e3pazjdi 239 20 traditionally traditionally RB cord-252725-e3pazjdi 239 21 used use VBN cord-252725-e3pazjdi 239 22 as as IN cord-252725-e3pazjdi 239 23 a a DT cord-252725-e3pazjdi 239 24 hemostatic hemostatic JJ cord-252725-e3pazjdi 239 25 agent agent NN cord-252725-e3pazjdi 239 26 inhibited inhibit VBD cord-252725-e3pazjdi 239 27 effectively effectively RB cord-252725-e3pazjdi 239 28 rotavirus rotavirus JJ cord-252725-e3pazjdi 239 29 multiplication multiplication NN cord-252725-e3pazjdi 239 30 by by IN cord-252725-e3pazjdi 239 31 promoting promote VBG cord-252725-e3pazjdi 239 32 virus virus NN cord-252725-e3pazjdi 239 33 - - HYPH cord-252725-e3pazjdi 239 34 induced induce VBN cord-252725-e3pazjdi 239 35 apoptosis apoptosis NN cord-252725-e3pazjdi 239 36 in in IN cord-252725-e3pazjdi 239 37 MA-104 ma-104 NN cord-252725-e3pazjdi 239 38 cells cell NNS cord-252725-e3pazjdi 239 39 [ [ -LRB- cord-252725-e3pazjdi 239 40 169 169 CD cord-252725-e3pazjdi 239 41 ] ] -RRB- cord-252725-e3pazjdi 239 42 . . . cord-252725-e3pazjdi 240 1 Consequently consequently RB cord-252725-e3pazjdi 240 2 , , , cord-252725-e3pazjdi 240 3 vanillic vanillic JJ cord-252725-e3pazjdi 240 4 acid acid NN cord-252725-e3pazjdi 240 5 may may MD cord-252725-e3pazjdi 240 6 have have VB cord-252725-e3pazjdi 240 7 a a DT cord-252725-e3pazjdi 240 8 role role NN cord-252725-e3pazjdi 240 9 in in IN cord-252725-e3pazjdi 240 10 the the DT cord-252725-e3pazjdi 240 11 combat combat NN cord-252725-e3pazjdi 240 12 against against IN cord-252725-e3pazjdi 240 13 pneumonia pneumonia NN cord-252725-e3pazjdi 240 14 related relate VBD cord-252725-e3pazjdi 240 15 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 240 16 infection infection NN cord-252725-e3pazjdi 240 17 . . . cord-252725-e3pazjdi 241 1 Galangin Galangin NNP cord-252725-e3pazjdi 241 2 ( ( -LRB- cord-252725-e3pazjdi 241 3 3,5,7-trihydroxyflavone 3,5,7-trihydroxyflavone CD cord-252725-e3pazjdi 241 4 ) ) -RRB- cord-252725-e3pazjdi 241 5 ( ( -LRB- cord-252725-e3pazjdi 241 6 Fig Fig NNP cord-252725-e3pazjdi 241 7 . . . cord-252725-e3pazjdi 241 8 17 17 CD cord-252725-e3pazjdi 241 9 ) ) -RRB- cord-252725-e3pazjdi 241 10 , , , cord-252725-e3pazjdi 241 11 is be VBZ cord-252725-e3pazjdi 241 12 a a DT cord-252725-e3pazjdi 241 13 flavonoid flavonoid NN cord-252725-e3pazjdi 241 14 compound compound NN cord-252725-e3pazjdi 241 15 found find VBN cord-252725-e3pazjdi 241 16 in in IN cord-252725-e3pazjdi 241 17 high high JJ cord-252725-e3pazjdi 241 18 concentrations concentration NNS cord-252725-e3pazjdi 241 19 in in IN cord-252725-e3pazjdi 241 20 Alpinia Alpinia NNP cord-252725-e3pazjdi 241 21 officinarum officinarum NN cord-252725-e3pazjdi 241 22 Hance Hance NNP cord-252725-e3pazjdi 241 23 ( ( -LRB- cord-252725-e3pazjdi 241 24 lesser less JJR cord-252725-e3pazjdi 241 25 galangal galangal NN cord-252725-e3pazjdi 241 26 ) ) -RRB- cord-252725-e3pazjdi 241 27 , , , cord-252725-e3pazjdi 241 28 which which WDT cord-252725-e3pazjdi 241 29 has have VBZ cord-252725-e3pazjdi 241 30 been be VBN cord-252725-e3pazjdi 241 31 used use VBN cord-252725-e3pazjdi 241 32 as as IN cord-252725-e3pazjdi 241 33 an an DT cord-252725-e3pazjdi 241 34 herbal herbal JJ cord-252725-e3pazjdi 241 35 medicine medicine NN cord-252725-e3pazjdi 241 36 for for IN cord-252725-e3pazjdi 241 37 colds cold NNS cord-252725-e3pazjdi 241 38 , , , cord-252725-e3pazjdi 241 39 stomachaches stomachache NNS cord-252725-e3pazjdi 241 40 , , , cord-252725-e3pazjdi 241 41 and and CC cord-252725-e3pazjdi 241 42 swellings swelling NNS cord-252725-e3pazjdi 241 43 , , , cord-252725-e3pazjdi 241 44 or or CC cord-252725-e3pazjdi 241 45 as as IN cord-252725-e3pazjdi 241 46 a a DT cord-252725-e3pazjdi 241 47 food food NN cord-252725-e3pazjdi 241 48 additive additive NN cord-252725-e3pazjdi 241 49 in in IN cord-252725-e3pazjdi 241 50 Asia Asia NNP cord-252725-e3pazjdi 241 51 . . . cord-252725-e3pazjdi 242 1 Galangin Galangin NNP cord-252725-e3pazjdi 242 2 , , , cord-252725-e3pazjdi 242 3 which which WDT cord-252725-e3pazjdi 242 4 has have VBZ cord-252725-e3pazjdi 242 5 been be VBN cord-252725-e3pazjdi 242 6 used use VBN cord-252725-e3pazjdi 242 7 as as IN cord-252725-e3pazjdi 242 8 a a DT cord-252725-e3pazjdi 242 9 cure cure NN cord-252725-e3pazjdi 242 10 for for IN cord-252725-e3pazjdi 242 11 many many JJ cord-252725-e3pazjdi 242 12 symptoms symptom NNS cord-252725-e3pazjdi 242 13 , , , cord-252725-e3pazjdi 242 14 particularly particularly RB cord-252725-e3pazjdi 242 15 in in IN cord-252725-e3pazjdi 242 16 China China NNP cord-252725-e3pazjdi 242 17 is be VBZ cord-252725-e3pazjdi 242 18 also also RB cord-252725-e3pazjdi 242 19 found find VBN cord-252725-e3pazjdi 242 20 in in IN cord-252725-e3pazjdi 242 21 honey honey NN cord-252725-e3pazjdi 242 22 , , , cord-252725-e3pazjdi 242 23 propolis propolis NN cord-252725-e3pazjdi 242 24 and and CC cord-252725-e3pazjdi 242 25 Helichrysum Helichrysum NNP cord-252725-e3pazjdi 242 26 aureonitens aureoniten VBD cord-252725-e3pazjdi 242 27 [ [ -LRB- cord-252725-e3pazjdi 242 28 170 170 CD cord-252725-e3pazjdi 242 29 ] ] -RRB- cord-252725-e3pazjdi 242 30 . . . cord-252725-e3pazjdi 243 1 Several several JJ cord-252725-e3pazjdi 243 2 epidemiological epidemiological JJ cord-252725-e3pazjdi 243 3 studies study NNS cord-252725-e3pazjdi 243 4 in in IN cord-252725-e3pazjdi 243 5 vitro vitro FW cord-252725-e3pazjdi 243 6 and and CC cord-252725-e3pazjdi 243 7 animal animal NN cord-252725-e3pazjdi 243 8 studies study NNS cord-252725-e3pazjdi 243 9 have have VBP cord-252725-e3pazjdi 243 10 claimed claim VBN cord-252725-e3pazjdi 243 11 that that IN cord-252725-e3pazjdi 243 12 galangin galangin NNP cord-252725-e3pazjdi 243 13 and and CC cord-252725-e3pazjdi 243 14 the the DT cord-252725-e3pazjdi 243 15 consumption consumption NN cord-252725-e3pazjdi 243 16 of of IN cord-252725-e3pazjdi 243 17 galangin galangin NNP cord-252725-e3pazjdi 243 18 - - HYPH cord-252725-e3pazjdi 243 19 containing contain VBG cord-252725-e3pazjdi 243 20 foods food NNS cord-252725-e3pazjdi 243 21 may may MD cord-252725-e3pazjdi 243 22 affect affect VB cord-252725-e3pazjdi 243 23 several several JJ cord-252725-e3pazjdi 243 24 diseases disease NNS cord-252725-e3pazjdi 243 25 [ [ -LRB- cord-252725-e3pazjdi 243 26 171 171 CD cord-252725-e3pazjdi 243 27 ] ] -RRB- cord-252725-e3pazjdi 243 28 . . . cord-252725-e3pazjdi 244 1 Galangin Galangin NNP cord-252725-e3pazjdi 244 2 has have VBZ cord-252725-e3pazjdi 244 3 a a DT cord-252725-e3pazjdi 244 4 broad broad JJ cord-252725-e3pazjdi 244 5 range range NN cord-252725-e3pazjdi 244 6 of of IN cord-252725-e3pazjdi 244 7 biological biological JJ cord-252725-e3pazjdi 244 8 properties property NNS cord-252725-e3pazjdi 244 9 , , , cord-252725-e3pazjdi 244 10 including include VBG cord-252725-e3pazjdi 244 11 anti anti JJ cord-252725-e3pazjdi 244 12 - - JJ cord-252725-e3pazjdi 244 13 oxidative oxidative JJ cord-252725-e3pazjdi 244 14 and and CC cord-252725-e3pazjdi 244 15 free free JJ cord-252725-e3pazjdi 244 16 radical radical JJ cord-252725-e3pazjdi 244 17 scavenging scavenging NN cord-252725-e3pazjdi 244 18 , , , cord-252725-e3pazjdi 244 19 modulating modulate VBG cord-252725-e3pazjdi 244 20 enzyme enzyme NN cord-252725-e3pazjdi 244 21 activities activity NNS cord-252725-e3pazjdi 244 22 , , , cord-252725-e3pazjdi 244 23 suppressing suppress VBG cord-252725-e3pazjdi 244 24 chemical chemical NN cord-252725-e3pazjdi 244 25 genotoxicity genotoxicity NN cord-252725-e3pazjdi 244 26 , , , cord-252725-e3pazjdi 244 27 inhibitory inhibitory JJ cord-252725-e3pazjdi 244 28 effects effect NNS cord-252725-e3pazjdi 244 29 on on IN cord-252725-e3pazjdi 244 30 various various JJ cord-252725-e3pazjdi 244 31 microbes microbe NNS cord-252725-e3pazjdi 244 32 , , , cord-252725-e3pazjdi 244 33 the the DT cord-252725-e3pazjdi 244 34 control control NN cord-252725-e3pazjdi 244 35 of of IN cord-252725-e3pazjdi 244 36 hypertension hypertension NN cord-252725-e3pazjdi 244 37 , , , cord-252725-e3pazjdi 244 38 diabetes diabetes NN cord-252725-e3pazjdi 244 39 , , , cord-252725-e3pazjdi 244 40 and and CC cord-252725-e3pazjdi 244 41 chemoprevention chemoprevention NN cord-252725-e3pazjdi 244 42 of of IN cord-252725-e3pazjdi 244 43 several several JJ cord-252725-e3pazjdi 244 44 cancers cancer NNS cord-252725-e3pazjdi 244 45 anti anti JJ cord-252725-e3pazjdi 244 46 - - JJ cord-252725-e3pazjdi 244 47 inflammatory inflammatory JJ cord-252725-e3pazjdi 244 48 and and CC cord-252725-e3pazjdi 244 49 anti anti JJ cord-252725-e3pazjdi 244 50 - - JJ cord-252725-e3pazjdi 244 51 fibrotic fibrotic JJ cord-252725-e3pazjdi 244 52 activities activity NNS cord-252725-e3pazjdi 244 53 in in IN cord-252725-e3pazjdi 244 54 various various JJ cord-252725-e3pazjdi 244 55 disorders disorder NNS cord-252725-e3pazjdi 244 56 [ [ -LRB- cord-252725-e3pazjdi 244 57 172 172 CD cord-252725-e3pazjdi 244 58 ] ] -RRB- cord-252725-e3pazjdi 244 59 [ [ -LRB- cord-252725-e3pazjdi 244 60 173 173 CD cord-252725-e3pazjdi 244 61 ] ] -RRB- cord-252725-e3pazjdi 244 62 [ [ -LRB- cord-252725-e3pazjdi 244 63 174 174 CD cord-252725-e3pazjdi 244 64 ] ] -RRB- cord-252725-e3pazjdi 244 65 . . . cord-252725-e3pazjdi 245 1 Galangin Galangin NNP cord-252725-e3pazjdi 245 2 attenuated attenuate VBN cord-252725-e3pazjdi 245 3 in in IN cord-252725-e3pazjdi 245 4 vitro vitro FW cord-252725-e3pazjdi 245 5 and and CC cord-252725-e3pazjdi 245 6 in in IN cord-252725-e3pazjdi 245 7 vivo vivo NNP cord-252725-e3pazjdi 245 8 airway airway NN cord-252725-e3pazjdi 245 9 remodeling remodeling NN cord-252725-e3pazjdi 245 10 by by IN cord-252725-e3pazjdi 245 11 inhibiting inhibit VBG cord-252725-e3pazjdi 245 12 TGF TGF NNP cord-252725-e3pazjdi 245 13 - - HYPH cord-252725-e3pazjdi 245 14 β1-mediated β1-mediate VBN cord-252725-e3pazjdi 245 15 ROS ROS NNP cord-252725-e3pazjdi 245 16 generation generation NN cord-252725-e3pazjdi 245 17 and and CC cord-252725-e3pazjdi 245 18 MAPK MAPK NNP cord-252725-e3pazjdi 245 19 / / SYM cord-252725-e3pazjdi 245 20 Akt Akt NNP cord-252725-e3pazjdi 245 21 phosphorylation phosphorylation NN cord-252725-e3pazjdi 245 22 in in IN cord-252725-e3pazjdi 245 23 asthma asthma NN cord-252725-e3pazjdi 245 24 ; ; : cord-252725-e3pazjdi 245 25 also also RB cord-252725-e3pazjdi 245 26 , , , cord-252725-e3pazjdi 245 27 galangin galangin NNP cord-252725-e3pazjdi 245 28 improved improve VBD cord-252725-e3pazjdi 245 29 ovalbumin ovalbumin NNP cord-252725-e3pazjdi 245 30 ( ( -LRB- cord-252725-e3pazjdi 245 31 OVA)induced ova)induce VBN cord-252725-e3pazjdi 245 32 airway airway NN cord-252725-e3pazjdi 245 33 inflammation inflammation NN cord-252725-e3pazjdi 245 34 by by IN cord-252725-e3pazjdi 245 35 inhibiting inhibit VBG cord-252725-e3pazjdi 245 36 NF nf NN cord-252725-e3pazjdi 245 37 - - HYPH cord-252725-e3pazjdi 245 38 κB κB NNP cord-252725-e3pazjdi 245 39 pathway pathway NN cord-252725-e3pazjdi 245 40 , , , cord-252725-e3pazjdi 245 41 which which WDT cord-252725-e3pazjdi 245 42 reduced reduce VBD cord-252725-e3pazjdi 245 43 eosinophils eosinophil NNS cord-252725-e3pazjdi 245 44 , , , cord-252725-e3pazjdi 245 45 neutrophils neutrophil NNS cord-252725-e3pazjdi 245 46 , , , cord-252725-e3pazjdi 245 47 and and CC cord-252725-e3pazjdi 245 48 lymphocytes lymphocyte VBZ cord-252725-e3pazjdi 245 49 infiltration infiltration NN cord-252725-e3pazjdi 245 50 and and CC cord-252725-e3pazjdi 245 51 goblet goblet NN cord-252725-e3pazjdi 245 52 cell cell NN cord-252725-e3pazjdi 245 53 hyperplasia hyperplasia NN cord-252725-e3pazjdi 245 54 . . . cord-252725-e3pazjdi 246 1 In in IN cord-252725-e3pazjdi 246 2 addition addition NN cord-252725-e3pazjdi 246 3 , , , cord-252725-e3pazjdi 246 4 galangin galangin NNP cord-252725-e3pazjdi 246 5 reduced reduce VBN cord-252725-e3pazjdi 246 6 expression expression NN cord-252725-e3pazjdi 246 7 of of IN cord-252725-e3pazjdi 246 8 iNOS inos NN cord-252725-e3pazjdi 246 9 , , , cord-252725-e3pazjdi 246 10 VCAM-1 VCAM-1 NNP cord-252725-e3pazjdi 246 11 , , , cord-252725-e3pazjdi 246 12 TNFα TNFα NNP cord-252725-e3pazjdi 246 13 induced induce VBD cord-252725-e3pazjdi 246 14 p65 p65 NN cord-252725-e3pazjdi 246 15 nuclear nuclear JJ cord-252725-e3pazjdi 246 16 translocation translocation NN cord-252725-e3pazjdi 246 17 , , , cord-252725-e3pazjdi 246 18 expression expression NN cord-252725-e3pazjdi 246 19 of of IN cord-252725-e3pazjdi 246 20 monocyte monocyte NNP cord-252725-e3pazjdi 246 21 chemoattractant chemoattractant NNP cord-252725-e3pazjdi 246 22 protein-1 protein-1 NNP cord-252725-e3pazjdi 246 23 ( ( -LRB- cord-252725-e3pazjdi 246 24 MCP-1 MCP-1 NNP cord-252725-e3pazjdi 246 25 ) ) -RRB- cord-252725-e3pazjdi 246 26 , , , cord-252725-e3pazjdi 246 27 eotaxin eotaxin NNP cord-252725-e3pazjdi 246 28 , , , cord-252725-e3pazjdi 246 29 and and CC cord-252725-e3pazjdi 246 30 C C NNP cord-252725-e3pazjdi 246 31 - - HYPH cord-252725-e3pazjdi 246 32 X x NN cord-252725-e3pazjdi 246 33 - - HYPH cord-252725-e3pazjdi 246 34 C c NN cord-252725-e3pazjdi 246 35 motif motif NN cord-252725-e3pazjdi 246 36 chemokine chemokine NN cord-252725-e3pazjdi 246 37 10 10 CD cord-252725-e3pazjdi 246 38 ( ( -LRB- cord-252725-e3pazjdi 246 39 CXCL10 cxcl10 NN cord-252725-e3pazjdi 246 40 ) ) -RRB- cord-252725-e3pazjdi 246 41 levels level NNS cord-252725-e3pazjdi 246 42 in in IN cord-252725-e3pazjdi 246 43 lung lung NN cord-252725-e3pazjdi 246 44 tissue tissue NN cord-252725-e3pazjdi 246 45 [ [ -LRB- cord-252725-e3pazjdi 246 46 175 175 CD cord-252725-e3pazjdi 246 47 , , , cord-252725-e3pazjdi 246 48 176 176 CD cord-252725-e3pazjdi 246 49 ] ] -RRB- cord-252725-e3pazjdi 246 50 . . . cord-252725-e3pazjdi 247 1 In in IN cord-252725-e3pazjdi 247 2 addition addition NN cord-252725-e3pazjdi 247 3 , , , cord-252725-e3pazjdi 247 4 galangin galangin NNP cord-252725-e3pazjdi 247 5 reduced reduce VBN cord-252725-e3pazjdi 247 6 LPS LPS NNP cord-252725-e3pazjdi 247 7 - - HYPH cord-252725-e3pazjdi 247 8 induced induce VBN cord-252725-e3pazjdi 247 9 acute acute JJ cord-252725-e3pazjdi 247 10 lung lung NN cord-252725-e3pazjdi 247 11 injury injury NN cord-252725-e3pazjdi 247 12 by by IN cord-252725-e3pazjdi 247 13 inhibition inhibition NN cord-252725-e3pazjdi 247 14 of of IN cord-252725-e3pazjdi 247 15 inflammation inflammation NN cord-252725-e3pazjdi 247 16 and and CC cord-252725-e3pazjdi 247 17 oxidative oxidative JJ cord-252725-e3pazjdi 247 18 stress stress NN cord-252725-e3pazjdi 247 19 . . . cord-252725-e3pazjdi 248 1 In in IN cord-252725-e3pazjdi 248 2 fact fact NN cord-252725-e3pazjdi 248 3 , , , cord-252725-e3pazjdi 248 4 protective protective JJ cord-252725-e3pazjdi 248 5 effects effect NNS cord-252725-e3pazjdi 248 6 of of IN cord-252725-e3pazjdi 248 7 galangin galangin NNP cord-252725-e3pazjdi 248 8 were be VBD cord-252725-e3pazjdi 248 9 associated associate VBN cord-252725-e3pazjdi 248 10 with with IN cord-252725-e3pazjdi 248 11 inhibition inhibition NN cord-252725-e3pazjdi 248 12 of of IN cord-252725-e3pazjdi 248 13 NF nf NN cord-252725-e3pazjdi 248 14 - - HYPH cord-252725-e3pazjdi 248 15 κB κb NN cord-252725-e3pazjdi 248 16 and and CC cord-252725-e3pazjdi 248 17 upregulation upregulation NN cord-252725-e3pazjdi 248 18 of of IN cord-252725-e3pazjdi 248 19 heme heme NN cord-252725-e3pazjdi 248 20 oxygenase oxygenase NN cord-252725-e3pazjdi 248 21 ( ( -LRB- cord-252725-e3pazjdi 248 22 HO)-1 HO)-1 NNP cord-252725-e3pazjdi 248 23 . . . cord-252725-e3pazjdi 249 1 Similarly similarly RB cord-252725-e3pazjdi 249 2 , , , cord-252725-e3pazjdi 249 3 galangin galangin NNP cord-252725-e3pazjdi 249 4 exerted exert VBD cord-252725-e3pazjdi 249 5 profound profound JJ cord-252725-e3pazjdi 249 6 anti anti JJ cord-252725-e3pazjdi 249 7 - - JJ cord-252725-e3pazjdi 249 8 asthmatic asthmatic JJ cord-252725-e3pazjdi 249 9 property property NN cord-252725-e3pazjdi 249 10 by by IN cord-252725-e3pazjdi 249 11 activating activate VBG cord-252725-e3pazjdi 249 12 PPARγ PPARγ NNS cord-252725-e3pazjdi 249 13 , , , cord-252725-e3pazjdi 249 14 which which WDT cord-252725-e3pazjdi 249 15 resulted result VBD cord-252725-e3pazjdi 249 16 in in IN cord-252725-e3pazjdi 249 17 galangin galangin NNP cord-252725-e3pazjdi 249 18 alleviating alleviate VBG cord-252725-e3pazjdi 249 19 airway airway JJ cord-252725-e3pazjdi 249 20 inflammation inflammation NN cord-252725-e3pazjdi 249 21 in in IN cord-252725-e3pazjdi 249 22 murine murine JJ cord-252725-e3pazjdi 249 23 model model NN cord-252725-e3pazjdi 249 24 of of IN cord-252725-e3pazjdi 249 25 asthma asthma NN cord-252725-e3pazjdi 249 26 . . . cord-252725-e3pazjdi 250 1 [ [ -LRB- cord-252725-e3pazjdi 250 2 176 176 CD cord-252725-e3pazjdi 250 3 ] ] -RRB- cord-252725-e3pazjdi 250 4 [ [ -LRB- cord-252725-e3pazjdi 250 5 177 177 CD cord-252725-e3pazjdi 250 6 ] ] -RRB- cord-252725-e3pazjdi 250 7 [ [ -LRB- cord-252725-e3pazjdi 250 8 178 178 CD cord-252725-e3pazjdi 250 9 ] ] -RRB- cord-252725-e3pazjdi 250 10 . . . cord-252725-e3pazjdi 251 1 Furthermore furthermore RB cord-252725-e3pazjdi 251 2 , , , cord-252725-e3pazjdi 251 3 at at IN cord-252725-e3pazjdi 251 4 concentrations concentration NNS cord-252725-e3pazjdi 251 5 ranging range VBG cord-252725-e3pazjdi 251 6 from from IN cord-252725-e3pazjdi 251 7 12 12 CD cord-252725-e3pazjdi 251 8 to to IN cord-252725-e3pazjdi 251 9 47 47 CD cord-252725-e3pazjdi 251 10 µg/ µg/ NNS cord-252725-e3pazjdi 251 11 mL mL NNP cord-252725-e3pazjdi 251 12 , , , cord-252725-e3pazjdi 251 13 galangin galangin NNP cord-252725-e3pazjdi 251 14 isolated isolate VBN cord-252725-e3pazjdi 251 15 from from IN cord-252725-e3pazjdi 251 16 the the DT cord-252725-e3pazjdi 251 17 aerial aerial JJ cord-252725-e3pazjdi 251 18 parts part NNS cord-252725-e3pazjdi 251 19 of of IN cord-252725-e3pazjdi 251 20 helichrysum helichrysum NNP cord-252725-e3pazjdi 251 21 aureonitens aureonitens NNP cord-252725-e3pazjdi 251 22 showed show VBD cord-252725-e3pazjdi 251 23 a a DT cord-252725-e3pazjdi 251 24 significant significant JJ cord-252725-e3pazjdi 251 25 antiviral antiviral JJ cord-252725-e3pazjdi 251 26 activity activity NN cord-252725-e3pazjdi 251 27 against against IN cord-252725-e3pazjdi 251 28 herpes herpes NNP cord-252725-e3pazjdi 251 29 simplex simplex NNP cord-252725-e3pazjdi 251 30 virus virus NN cord-252725-e3pazjdi 251 31 type type NN cord-252725-e3pazjdi 251 32 1 1 CD cord-252725-e3pazjdi 251 33 ( ( -LRB- cord-252725-e3pazjdi 251 34 HSV-1 HSV-1 NNP cord-252725-e3pazjdi 251 35 ) ) -RRB- cord-252725-e3pazjdi 251 36 and and CC cord-252725-e3pazjdi 251 37 coxsackie coxsackie NNP cord-252725-e3pazjdi 251 38 B B NNP cord-252725-e3pazjdi 251 39 virus virus NN cord-252725-e3pazjdi 251 40 type type NN cord-252725-e3pazjdi 251 41 1 1 CD cord-252725-e3pazjdi 251 42 ( ( -LRB- cord-252725-e3pazjdi 251 43 CoxB1 CoxB1 NNP cord-252725-e3pazjdi 251 44 ) ) -RRB- cord-252725-e3pazjdi 251 45 limited limited JJ cord-252725-e3pazjdi 251 46 activity activity NN cord-252725-e3pazjdi 251 47 against against IN cord-252725-e3pazjdi 251 48 reovirus reovirus NNP cord-252725-e3pazjdi 251 49 , , , cord-252725-e3pazjdi 251 50 but but CC cord-252725-e3pazjdi 251 51 no no DT cord-252725-e3pazjdi 251 52 antiviral antiviral JJ cord-252725-e3pazjdi 251 53 activity activity NN cord-252725-e3pazjdi 251 54 against against IN cord-252725-e3pazjdi 251 55 adenovirus adenovirus NN cord-252725-e3pazjdi 251 56 type type NN cord-252725-e3pazjdi 251 57 31 31 CD cord-252725-e3pazjdi 251 58 ( ( -LRB- cord-252725-e3pazjdi 251 59 Ad31 ad31 NN cord-252725-e3pazjdi 251 60 ) ) -RRB- cord-252725-e3pazjdi 251 61 [ [ -LRB- cord-252725-e3pazjdi 251 62 179 179 CD cord-252725-e3pazjdi 251 63 ] ] -RRB- cord-252725-e3pazjdi 251 64 . . . cord-252725-e3pazjdi 252 1 The the DT cord-252725-e3pazjdi 252 2 anti anti JJ cord-252725-e3pazjdi 252 3 - - JJ cord-252725-e3pazjdi 252 4 inflammatory inflammatory JJ cord-252725-e3pazjdi 252 5 and and CC cord-252725-e3pazjdi 252 6 anti anti JJ cord-252725-e3pazjdi 252 7 - - JJ cord-252725-e3pazjdi 252 8 oxidant oxidant JJ cord-252725-e3pazjdi 252 9 capacity capacity NN cord-252725-e3pazjdi 252 10 of of IN cord-252725-e3pazjdi 252 11 galangin galangin NNP cord-252725-e3pazjdi 252 12 may may MD cord-252725-e3pazjdi 252 13 give give VB cord-252725-e3pazjdi 252 14 it -PRON- PRP cord-252725-e3pazjdi 252 15 a a DT cord-252725-e3pazjdi 252 16 role role NN cord-252725-e3pazjdi 252 17 in in IN cord-252725-e3pazjdi 252 18 the the DT cord-252725-e3pazjdi 252 19 pneumonia pneumonia NN cord-252725-e3pazjdi 252 20 associated associate VBN cord-252725-e3pazjdi 252 21 with with IN cord-252725-e3pazjdi 252 22 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 252 23 and and CC cord-252725-e3pazjdi 252 24 other other JJ cord-252725-e3pazjdi 252 25 emergence emergence NN cord-252725-e3pazjdi 252 26 diseases disease NNS cord-252725-e3pazjdi 252 27 . . . cord-252725-e3pazjdi 253 1 p p LS cord-252725-e3pazjdi 253 2 - - : cord-252725-e3pazjdi 253 3 Coumaric Coumaric NNP cord-252725-e3pazjdi 253 4 acid acid NN cord-252725-e3pazjdi 253 5 ( ( -LRB- cord-252725-e3pazjdi 253 6 4-hydroxycinnamicacid 4-hydroxycinnamicacid CD cord-252725-e3pazjdi 253 7 ) ) -RRB- cord-252725-e3pazjdi 254 1 ( ( -LRB- cord-252725-e3pazjdi 254 2 Fig Fig NNP cord-252725-e3pazjdi 254 3 . . . cord-252725-e3pazjdi 254 4 18 18 CD cord-252725-e3pazjdi 254 5 ) ) -RRB- cord-252725-e3pazjdi 254 6 , , , cord-252725-e3pazjdi 254 7 is be VBZ cord-252725-e3pazjdi 254 8 a a DT cord-252725-e3pazjdi 254 9 phenolic phenolic JJ cord-252725-e3pazjdi 254 10 compound compound NN cord-252725-e3pazjdi 254 11 and and CC cord-252725-e3pazjdi 254 12 the the DT cord-252725-e3pazjdi 254 13 most most RBS cord-252725-e3pazjdi 254 14 frequently frequently RB cord-252725-e3pazjdi 254 15 occurring occur VBG cord-252725-e3pazjdi 254 16 isomer isomer NN cord-252725-e3pazjdi 254 17 of of IN cord-252725-e3pazjdi 254 18 coumaric coumaric JJ cord-252725-e3pazjdi 254 19 acid acid NN cord-252725-e3pazjdi 254 20 in in IN cord-252725-e3pazjdi 254 21 nature nature NN cord-252725-e3pazjdi 254 22 . . . cord-252725-e3pazjdi 255 1 p p LS cord-252725-e3pazjdi 255 2 - - : cord-252725-e3pazjdi 255 3 Coumaric Coumaric NNP cord-252725-e3pazjdi 255 4 acid acid NN cord-252725-e3pazjdi 255 5 classified classify VBD cord-252725-e3pazjdi 255 6 as as IN cord-252725-e3pazjdi 255 7 a a DT cord-252725-e3pazjdi 255 8 phytochemical phytochemical JJ cord-252725-e3pazjdi 255 9 and and CC cord-252725-e3pazjdi 255 10 nutraceutical nutraceutical NN cord-252725-e3pazjdi 255 11 , , , cord-252725-e3pazjdi 255 12 presents present VBZ cord-252725-e3pazjdi 255 13 in in IN cord-252725-e3pazjdi 255 14 vegetables vegetable NNS cord-252725-e3pazjdi 255 15 , , , cord-252725-e3pazjdi 255 16 and and CC cord-252725-e3pazjdi 255 17 fruits fruit NNS cord-252725-e3pazjdi 255 18 , , , cord-252725-e3pazjdi 255 19 such such JJ cord-252725-e3pazjdi 255 20 as as IN cord-252725-e3pazjdi 255 21 cranberry cranberry NN cord-252725-e3pazjdi 255 22 syrups syrup NNS cord-252725-e3pazjdi 255 23 , , , cord-252725-e3pazjdi 255 24 grape grape NN cord-252725-e3pazjdi 255 25 juices juice NNS cord-252725-e3pazjdi 255 26 , , , cord-252725-e3pazjdi 255 27 tomatoes tomato NNS cord-252725-e3pazjdi 255 28 , , , cord-252725-e3pazjdi 255 29 apple apple NN cord-252725-e3pazjdi 255 30 , , , cord-252725-e3pazjdi 255 31 peanuts peanut NNS cord-252725-e3pazjdi 255 32 , , , cord-252725-e3pazjdi 255 33 carrots carrot NNS cord-252725-e3pazjdi 255 34 , , , cord-252725-e3pazjdi 255 35 garlic garlic NN cord-252725-e3pazjdi 255 36 , , , cord-252725-e3pazjdi 255 37 potatoes potato NNS cord-252725-e3pazjdi 255 38 , , , cord-252725-e3pazjdi 255 39 onions onion NNS cord-252725-e3pazjdi 255 40 , , , cord-252725-e3pazjdi 255 41 beans bean NNS cord-252725-e3pazjdi 255 42 , , , cord-252725-e3pazjdi 255 43 and and CC cord-252725-e3pazjdi 255 44 cereals cereal NNS cord-252725-e3pazjdi 255 45 such such JJ cord-252725-e3pazjdi 255 46 as as IN cord-252725-e3pazjdi 255 47 rice rice NN cord-252725-e3pazjdi 255 48 maize maize NN cord-252725-e3pazjdi 255 49 , , , cord-252725-e3pazjdi 255 50 oats oats NN cord-252725-e3pazjdi 255 51 and and CC cord-252725-e3pazjdi 255 52 wheat wheat NN cord-252725-e3pazjdi 255 53 , , , cord-252725-e3pazjdi 255 54 tea tea NN cord-252725-e3pazjdi 255 55 , , , cord-252725-e3pazjdi 255 56 beer beer NN cord-252725-e3pazjdi 255 57 and and CC cord-252725-e3pazjdi 255 58 chocolate chocolate NN cord-252725-e3pazjdi 255 59 . . . cord-252725-e3pazjdi 256 1 p p LS cord-252725-e3pazjdi 256 2 - - : cord-252725-e3pazjdi 256 3 Coumaric Coumaric NNP cord-252725-e3pazjdi 256 4 acid acid NN cord-252725-e3pazjdi 256 5 and and CC cord-252725-e3pazjdi 256 6 its -PRON- PRP$ cord-252725-e3pazjdi 256 7 conjugate conjugate NN cord-252725-e3pazjdi 256 8 have have VBP cord-252725-e3pazjdi 256 9 demonstrated demonstrate VBN cord-252725-e3pazjdi 256 10 several several JJ cord-252725-e3pazjdi 256 11 biological biological JJ cord-252725-e3pazjdi 256 12 activities activity NNS cord-252725-e3pazjdi 256 13 including include VBG cord-252725-e3pazjdi 256 14 antifungal antifungal JJ cord-252725-e3pazjdi 256 15 , , , cord-252725-e3pazjdi 256 16 anti anti JJ cord-252725-e3pazjdi 256 17 - - JJ cord-252725-e3pazjdi 256 18 cancer cancer JJ cord-252725-e3pazjdi 256 19 , , , cord-252725-e3pazjdi 256 20 antimicrobial antimicrobial JJ cord-252725-e3pazjdi 256 21 , , , cord-252725-e3pazjdi 256 22 anti anti JJ cord-252725-e3pazjdi 256 23 - - JJ cord-252725-e3pazjdi 256 24 viral viral JJ cord-252725-e3pazjdi 256 25 , , , cord-252725-e3pazjdi 256 26 anti anti JJ cord-252725-e3pazjdi 256 27 - - JJ cord-252725-e3pazjdi 256 28 melanogenic melanogenic JJ cord-252725-e3pazjdi 256 29 , , , cord-252725-e3pazjdi 256 30 antioxidant antioxidant NN cord-252725-e3pazjdi 256 31 , , , cord-252725-e3pazjdi 256 32 immunomodulatory immunomodulatory JJ cord-252725-e3pazjdi 256 33 and and CC cord-252725-e3pazjdi 256 34 anti anti JJ cord-252725-e3pazjdi 256 35 - - JJ cord-252725-e3pazjdi 256 36 inflammatory inflammatory JJ cord-252725-e3pazjdi 256 37 effects effect NNS cord-252725-e3pazjdi 256 38 , , , cord-252725-e3pazjdi 256 39 antiplatelet antiplatelet NN cord-252725-e3pazjdi 256 40 aggregation aggregation NN cord-252725-e3pazjdi 256 41 , , , cord-252725-e3pazjdi 256 42 anxiolytic anxiolytic JJ cord-252725-e3pazjdi 256 43 , , , cord-252725-e3pazjdi 256 44 antipyretic antipyretic JJ cord-252725-e3pazjdi 256 45 , , , cord-252725-e3pazjdi 256 46 analgesic analgesic JJ cord-252725-e3pazjdi 256 47 , , , cord-252725-e3pazjdi 256 48 anti anti JJ cord-252725-e3pazjdi 256 49 - - JJ cord-252725-e3pazjdi 256 50 arthritis arthritis NN cord-252725-e3pazjdi 256 51 and and CC cord-252725-e3pazjdi 256 52 antigenotoxicity antigenotoxicity NN cord-252725-e3pazjdi 256 53 [ [ -LRB- cord-252725-e3pazjdi 256 54 180 180 CD cord-252725-e3pazjdi 256 55 ] ] -RRB- cord-252725-e3pazjdi 256 56 [ [ -LRB- cord-252725-e3pazjdi 256 57 181 181 CD cord-252725-e3pazjdi 256 58 ] ] -RRB- cord-252725-e3pazjdi 256 59 [ [ -LRB- cord-252725-e3pazjdi 256 60 182 182 CD cord-252725-e3pazjdi 256 61 ] ] -RRB- cord-252725-e3pazjdi 256 62 . . . cord-252725-e3pazjdi 257 1 In in IN cord-252725-e3pazjdi 257 2 vitro vitro FW cord-252725-e3pazjdi 257 3 and and CC cord-252725-e3pazjdi 257 4 in in IN cord-252725-e3pazjdi 257 5 vivo vivo NN cord-252725-e3pazjdi 257 6 experiments experiment NNS cord-252725-e3pazjdi 257 7 showed show VBD cord-252725-e3pazjdi 257 8 that that IN cord-252725-e3pazjdi 257 9 p p NN cord-252725-e3pazjdi 257 10 - - HYPH cord-252725-e3pazjdi 257 11 coumaric coumaric JJ cord-252725-e3pazjdi 257 12 acid acid NN cord-252725-e3pazjdi 257 13 attenuated attenuated JJ cord-252725-e3pazjdi 257 14 lipopolysaccharide lipopolysaccharide NN cord-252725-e3pazjdi 257 15 - - HYPH cord-252725-e3pazjdi 257 16 induced induce VBN cord-252725-e3pazjdi 257 17 lung lung NN cord-252725-e3pazjdi 257 18 inflammation inflammation NN cord-252725-e3pazjdi 257 19 by by IN cord-252725-e3pazjdi 257 20 scavenging scavenge VBG cord-252725-e3pazjdi 257 21 ROS ROS NNP cord-252725-e3pazjdi 257 22 production production NN cord-252725-e3pazjdi 257 23 and and CC cord-252725-e3pazjdi 257 24 modulating modulate VBG cord-252725-e3pazjdi 257 25 the the DT cord-252725-e3pazjdi 257 26 oxidative oxidative JJ cord-252725-e3pazjdi 257 27 stress stress NN cord-252725-e3pazjdi 257 28 under under IN cord-252725-e3pazjdi 257 29 inflammatory inflammatory JJ cord-252725-e3pazjdi 257 30 conditions condition NNS cord-252725-e3pazjdi 257 31 in in IN cord-252725-e3pazjdi 257 32 lung lung NN cord-252725-e3pazjdi 257 33 injury injury NN cord-252725-e3pazjdi 257 34 [ [ -LRB- cord-252725-e3pazjdi 257 35 180 180 CD cord-252725-e3pazjdi 257 36 ] ] -RRB- cord-252725-e3pazjdi 257 37 . . . cord-252725-e3pazjdi 258 1 Moreover moreover RB cord-252725-e3pazjdi 258 2 , , , cord-252725-e3pazjdi 258 3 Adenostemma Adenostemma NNP cord-252725-e3pazjdi 258 4 lavenia lavenia NNP cord-252725-e3pazjdi 258 5 is be VBZ cord-252725-e3pazjdi 258 6 a a DT cord-252725-e3pazjdi 258 7 permanent permanent JJ cord-252725-e3pazjdi 258 8 medicinal medicinal JJ cord-252725-e3pazjdi 258 9 herb herb NN cord-252725-e3pazjdi 258 10 belonging belong VBG cord-252725-e3pazjdi 258 11 to to IN cord-252725-e3pazjdi 258 12 the the DT cord-252725-e3pazjdi 258 13 Compositae Compositae NNP cord-252725-e3pazjdi 258 14 family family NN cord-252725-e3pazjdi 258 15 and and CC cord-252725-e3pazjdi 258 16 is be VBZ cord-252725-e3pazjdi 258 17 widely widely RB cord-252725-e3pazjdi 258 18 distributed distribute VBN cord-252725-e3pazjdi 258 19 in in IN cord-252725-e3pazjdi 258 20 the the DT cord-252725-e3pazjdi 258 21 tropical tropical JJ cord-252725-e3pazjdi 258 22 parts part NNS cord-252725-e3pazjdi 258 23 of of IN cord-252725-e3pazjdi 258 24 Asia Asia NNP cord-252725-e3pazjdi 258 25 mainly mainly RB cord-252725-e3pazjdi 258 26 in in IN cord-252725-e3pazjdi 258 27 Taiwan Taiwan NNP cord-252725-e3pazjdi 258 28 . . . cord-252725-e3pazjdi 259 1 It -PRON- PRP cord-252725-e3pazjdi 259 2 is be VBZ cord-252725-e3pazjdi 259 3 used use VBN cord-252725-e3pazjdi 259 4 to to TO cord-252725-e3pazjdi 259 5 treat treat VB cord-252725-e3pazjdi 259 6 pulmonary pulmonary JJ cord-252725-e3pazjdi 259 7 congestion congestion NN cord-252725-e3pazjdi 259 8 , , , cord-252725-e3pazjdi 259 9 pneumonia pneumonia NN cord-252725-e3pazjdi 259 10 , , , cord-252725-e3pazjdi 259 11 bacterial bacterial JJ cord-252725-e3pazjdi 259 12 infections infection NNS cord-252725-e3pazjdi 259 13 of of IN cord-252725-e3pazjdi 259 14 the the DT cord-252725-e3pazjdi 259 15 respiratory respiratory JJ cord-252725-e3pazjdi 259 16 tract tract NN cord-252725-e3pazjdi 259 17 , , , cord-252725-e3pazjdi 259 18 edema edema NN cord-252725-e3pazjdi 259 19 , , , cord-252725-e3pazjdi 259 20 and and CC cord-252725-e3pazjdi 259 21 inflammation inflammation NN cord-252725-e3pazjdi 259 22 . . . cord-252725-e3pazjdi 260 1 p p LS cord-252725-e3pazjdi 260 2 - - : cord-252725-e3pazjdi 260 3 Coumaric Coumaric NNP cord-252725-e3pazjdi 260 4 acid acid NN cord-252725-e3pazjdi 260 5 was be VBD cord-252725-e3pazjdi 260 6 found find VBN cord-252725-e3pazjdi 260 7 to to TO cord-252725-e3pazjdi 260 8 be be VB cord-252725-e3pazjdi 260 9 the the DT cord-252725-e3pazjdi 260 10 major major JJ cord-252725-e3pazjdi 260 11 constituent constituent NN cord-252725-e3pazjdi 260 12 of of IN cord-252725-e3pazjdi 260 13 this this DT cord-252725-e3pazjdi 260 14 herb herb NN cord-252725-e3pazjdi 260 15 . . . cord-252725-e3pazjdi 261 1 In in IN cord-252725-e3pazjdi 261 2 fact fact NN cord-252725-e3pazjdi 261 3 , , , cord-252725-e3pazjdi 261 4 Adenostemma Adenostemma NNP cord-252725-e3pazjdi 261 5 lavenia lavenia NNP cord-252725-e3pazjdi 261 6 has have VBZ cord-252725-e3pazjdi 261 7 been be VBN cord-252725-e3pazjdi 261 8 reported report VBN cord-252725-e3pazjdi 261 9 to to TO cord-252725-e3pazjdi 261 10 ameliorate ameliorate VB cord-252725-e3pazjdi 261 11 acute acute JJ cord-252725-e3pazjdi 261 12 lung lung NN cord-252725-e3pazjdi 261 13 injury injury NN cord-252725-e3pazjdi 261 14 through through IN cord-252725-e3pazjdi 261 15 activating activate VBG cord-252725-e3pazjdi 261 16 AMPK AMPK NNP cord-252725-e3pazjdi 262 1 /Nrf2 /Nrf2 NNP cord-252725-e3pazjdi 262 2 / / SYM cord-252725-e3pazjdi 262 3 HO-1 HO-1 NNP cord-252725-e3pazjdi 262 4 signaling signal VBG cord-252725-e3pazjdi 262 5 pathway pathway NN cord-252725-e3pazjdi 262 6 and and CC cord-252725-e3pazjdi 262 7 improving improve VBG cord-252725-e3pazjdi 262 8 the the DT cord-252725-e3pazjdi 262 9 anti anti JJ cord-252725-e3pazjdi 262 10 - - JJ cord-252725-e3pazjdi 262 11 oxidant oxidant JJ cord-252725-e3pazjdi 262 12 response response NN cord-252725-e3pazjdi 262 13 [ [ -LRB- cord-252725-e3pazjdi 262 14 183 183 CD cord-252725-e3pazjdi 262 15 ] ] -RRB- cord-252725-e3pazjdi 262 16 . . . cord-252725-e3pazjdi 263 1 p p LS cord-252725-e3pazjdi 263 2 - - : cord-252725-e3pazjdi 263 3 Coumaric Coumaric NNP cord-252725-e3pazjdi 263 4 acid acid NN cord-252725-e3pazjdi 263 5 among among IN cord-252725-e3pazjdi 263 6 other other JJ cord-252725-e3pazjdi 263 7 compounds compound NNS cord-252725-e3pazjdi 263 8 extracted extract VBN cord-252725-e3pazjdi 263 9 from from IN cord-252725-e3pazjdi 263 10 the the DT cord-252725-e3pazjdi 263 11 Himalayan himalayan JJ cord-252725-e3pazjdi 263 12 medicinal medicinal JJ cord-252725-e3pazjdi 263 13 plants plant NNS cord-252725-e3pazjdi 263 14 traditionally traditionally RB cord-252725-e3pazjdi 263 15 used use VBN cord-252725-e3pazjdi 263 16 to to TO cord-252725-e3pazjdi 263 17 treat treat VB cord-252725-e3pazjdi 263 18 bronchitis bronchitis NN cord-252725-e3pazjdi 263 19 and and CC cord-252725-e3pazjdi 263 20 related relate VBN cord-252725-e3pazjdi 263 21 symptoms symptom NNS cord-252725-e3pazjdi 263 22 has have VBZ cord-252725-e3pazjdi 263 23 demonstrated demonstrate VBN cord-252725-e3pazjdi 263 24 antiviral antiviral JJ cord-252725-e3pazjdi 263 25 activities activity NNS cord-252725-e3pazjdi 263 26 in in IN cord-252725-e3pazjdi 263 27 vitro vitro FW cord-252725-e3pazjdi 263 28 against against IN cord-252725-e3pazjdi 263 29 different different JJ cord-252725-e3pazjdi 263 30 kinds kind NNS cord-252725-e3pazjdi 263 31 of of IN cord-252725-e3pazjdi 263 32 human human JJ cord-252725-e3pazjdi 263 33 rhinoviruses rhinovirus NNS cord-252725-e3pazjdi 263 34 [ [ -LRB- cord-252725-e3pazjdi 263 35 184 184 CD cord-252725-e3pazjdi 263 36 ] ] -RRB- cord-252725-e3pazjdi 263 37 . . . cord-252725-e3pazjdi 264 1 Likewise likewise RB cord-252725-e3pazjdi 264 2 , , , cord-252725-e3pazjdi 264 3 in in IN cord-252725-e3pazjdi 264 4 vitro vitro FW cord-252725-e3pazjdi 264 5 research research NN cord-252725-e3pazjdi 264 6 showed show VBD cord-252725-e3pazjdi 264 7 that that IN cord-252725-e3pazjdi 264 8 p p NN cord-252725-e3pazjdi 264 9 - - HYPH cord-252725-e3pazjdi 264 10 coumaric coumaric JJ cord-252725-e3pazjdi 264 11 acid acid NN cord-252725-e3pazjdi 264 12 among among IN cord-252725-e3pazjdi 264 13 other other JJ cord-252725-e3pazjdi 264 14 phenolic phenolic JJ cord-252725-e3pazjdi 264 15 acid acid NN cord-252725-e3pazjdi 264 16 components component NNS cord-252725-e3pazjdi 264 17 extracted extract VBN cord-252725-e3pazjdi 264 18 from from IN cord-252725-e3pazjdi 264 19 propolis propolis NN cord-252725-e3pazjdi 264 20 could could MD cord-252725-e3pazjdi 264 21 be be VB cord-252725-e3pazjdi 264 22 effective effective JJ cord-252725-e3pazjdi 264 23 against against IN cord-252725-e3pazjdi 264 24 Herpes Herpes NNP cord-252725-e3pazjdi 264 25 Simplex Simplex NNP cord-252725-e3pazjdi 264 26 Virus Virus NNP cord-252725-e3pazjdi 264 27 [ [ -LRB- cord-252725-e3pazjdi 264 28 185 185 CD cord-252725-e3pazjdi 264 29 ] ] -RRB- cord-252725-e3pazjdi 264 30 . . . cord-252725-e3pazjdi 265 1 Furthermore furthermore RB cord-252725-e3pazjdi 265 2 , , , cord-252725-e3pazjdi 265 3 a a DT cord-252725-e3pazjdi 265 4 recent recent JJ cord-252725-e3pazjdi 265 5 docking docking NN cord-252725-e3pazjdi 265 6 study study NN cord-252725-e3pazjdi 265 7 has have VBZ cord-252725-e3pazjdi 265 8 reported report VBN cord-252725-e3pazjdi 265 9 that that IN cord-252725-e3pazjdi 265 10 cis cis NNP cord-252725-e3pazjdi 265 11 - - HYPH cord-252725-e3pazjdi 265 12 p p NNP cord-252725-e3pazjdi 265 13 - - : cord-252725-e3pazjdi 265 14 Coumaric Coumaric NNP cord-252725-e3pazjdi 265 15 acid acid NN cord-252725-e3pazjdi 265 16 found find VBN cord-252725-e3pazjdi 265 17 in in IN cord-252725-e3pazjdi 265 18 coriander coriander NN cord-252725-e3pazjdi 265 19 , , , cord-252725-e3pazjdi 265 20 the the DT cord-252725-e3pazjdi 265 21 cis cis NNP cord-252725-e3pazjdi 265 22 - - HYPH cord-252725-e3pazjdi 265 23 form form NN cord-252725-e3pazjdi 265 24 of of IN cord-252725-e3pazjdi 265 25 p p NN cord-252725-e3pazjdi 265 26 - - HYPH cord-252725-e3pazjdi 265 27 coumaric coumaric JJ cord-252725-e3pazjdi 265 28 acid acid NN cord-252725-e3pazjdi 265 29 , , , cord-252725-e3pazjdi 265 30 among among IN cord-252725-e3pazjdi 265 31 other other JJ cord-252725-e3pazjdi 265 32 natural natural JJ cord-252725-e3pazjdi 265 33 products product NNS cord-252725-e3pazjdi 265 34 may may MD cord-252725-e3pazjdi 265 35 interfere interfere VB cord-252725-e3pazjdi 265 36 with with IN cord-252725-e3pazjdi 265 37 SARS SARS NNP cord-252725-e3pazjdi 265 38 - - HYPH cord-252725-e3pazjdi 265 39 CoV-2 CoV-2 NNP cord-252725-e3pazjdi 265 40 attachment attachment NN cord-252725-e3pazjdi 265 41 to to IN cord-252725-e3pazjdi 265 42 the the DT cord-252725-e3pazjdi 265 43 host host NN cord-252725-e3pazjdi 265 44 cell cell NN cord-252725-e3pazjdi 265 45 and and CC cord-252725-e3pazjdi 265 46 can can MD cord-252725-e3pazjdi 265 47 be be VB cord-252725-e3pazjdi 265 48 successfully successfully RB cord-252725-e3pazjdi 265 49 considered consider VBN cord-252725-e3pazjdi 265 50 as as IN cord-252725-e3pazjdi 265 51 anti anti JJ cord-252725-e3pazjdi 265 52 - - JJ cord-252725-e3pazjdi 265 53 COVID-19 covid-19 JJ cord-252725-e3pazjdi 265 54 agents agent NNS cord-252725-e3pazjdi 265 55 for for IN cord-252725-e3pazjdi 265 56 people people NNS cord-252725-e3pazjdi 265 57 with with IN cord-252725-e3pazjdi 265 58 a a DT cord-252725-e3pazjdi 265 59 high high JJ cord-252725-e3pazjdi 265 60 risk risk NN cord-252725-e3pazjdi 265 61 of of IN cord-252725-e3pazjdi 265 62 cell cell NN cord-252725-e3pazjdi 265 63 stress stress NN cord-252725-e3pazjdi 265 64 like like IN cord-252725-e3pazjdi 265 65 elders elder NNS cord-252725-e3pazjdi 265 66 , , , cord-252725-e3pazjdi 265 67 cancer cancer NN cord-252725-e3pazjdi 265 68 patients patient NNS cord-252725-e3pazjdi 265 69 , , , cord-252725-e3pazjdi 265 70 and and CC cord-252725-e3pazjdi 265 71 front front JJ cord-252725-e3pazjdi 265 72 - - HYPH cord-252725-e3pazjdi 265 73 line line NN cord-252725-e3pazjdi 265 74 medical medical JJ cord-252725-e3pazjdi 265 75 staff staff NN cord-252725-e3pazjdi 265 76 . . . cord-252725-e3pazjdi 266 1 Similarly similarly RB cord-252725-e3pazjdi 266 2 , , , cord-252725-e3pazjdi 266 3 another another DT cord-252725-e3pazjdi 266 4 docking docking NN cord-252725-e3pazjdi 266 5 study study NN cord-252725-e3pazjdi 266 6 showed show VBD cord-252725-e3pazjdi 266 7 that that IN cord-252725-e3pazjdi 266 8 p p NN cord-252725-e3pazjdi 266 9 - - : cord-252725-e3pazjdi 266 10 Coumaric Coumaric NNP cord-252725-e3pazjdi 266 11 acid acid NN cord-252725-e3pazjdi 266 12 , , , cord-252725-e3pazjdi 266 13 Curcumin curcumin NN cord-252725-e3pazjdi 266 14 and and CC cord-252725-e3pazjdi 266 15 their -PRON- PRP$ cord-252725-e3pazjdi 266 16 boronic boronic JJ cord-252725-e3pazjdi 266 17 acid acid NN cord-252725-e3pazjdi 266 18 derivatives derivative NNS cord-252725-e3pazjdi 266 19 are be VBP cord-252725-e3pazjdi 266 20 probable probable JJ cord-252725-e3pazjdi 266 21 inhibitors inhibitor NNS cord-252725-e3pazjdi 266 22 of of IN cord-252725-e3pazjdi 266 23 endoribonuclease endoribonuclease NNP cord-252725-e3pazjdi 266 24 Nsp15 Nsp15 NNP cord-252725-e3pazjdi 266 25 encoded encode VBN cord-252725-e3pazjdi 266 26 by by IN cord-252725-e3pazjdi 266 27 Middle Middle NNP cord-252725-e3pazjdi 266 28 East East NNP cord-252725-e3pazjdi 266 29 Respiratory Respiratory NNP cord-252725-e3pazjdi 266 30 Syndrome Syndrome NNP cord-252725-e3pazjdi 266 31 Coronavirus Coronavirus NNP cord-252725-e3pazjdi 266 32 ( ( -LRB- cord-252725-e3pazjdi 266 33 MERS MERS NNP cord-252725-e3pazjdi 266 34 - - HYPH cord-252725-e3pazjdi 266 35 CoV CoV NNP cord-252725-e3pazjdi 266 36 ) ) -RRB- cord-252725-e3pazjdi 267 1 [ [ -LRB- cord-252725-e3pazjdi 267 2 186 186 CD cord-252725-e3pazjdi 267 3 , , , cord-252725-e3pazjdi 267 4 187 187 CD cord-252725-e3pazjdi 267 5 ] ] -RRB- cord-252725-e3pazjdi 267 6 . . . cord-252725-e3pazjdi 268 1 Consequently consequently RB cord-252725-e3pazjdi 268 2 , , , cord-252725-e3pazjdi 268 3 p p LS cord-252725-e3pazjdi 268 4 - - : cord-252725-e3pazjdi 268 5 Coumaric Coumaric NNP cord-252725-e3pazjdi 268 6 acid acid NN cord-252725-e3pazjdi 268 7 and and CC cord-252725-e3pazjdi 268 8 its -PRON- PRP$ cord-252725-e3pazjdi 268 9 derivatives derivative NNS cord-252725-e3pazjdi 268 10 may may MD cord-252725-e3pazjdi 268 11 be be VB cord-252725-e3pazjdi 268 12 used use VBN cord-252725-e3pazjdi 268 13 as as IN cord-252725-e3pazjdi 268 14 target target NN cord-252725-e3pazjdi 268 15 for for IN cord-252725-e3pazjdi 268 16 an an DT cord-252725-e3pazjdi 268 17 alternative alternative JJ cord-252725-e3pazjdi 268 18 therapy therapy NN cord-252725-e3pazjdi 268 19 of of IN cord-252725-e3pazjdi 268 20 covid19 covid19 NNP cord-252725-e3pazjdi 268 21 and and CC cord-252725-e3pazjdi 268 22 its -PRON- PRP$ cord-252725-e3pazjdi 268 23 related related JJ cord-252725-e3pazjdi 268 24 pneumonia pneumonia NN cord-252725-e3pazjdi 268 25 . . . cord-252725-e3pazjdi 269 1 Eriodictyol Eriodictyol NNP cord-252725-e3pazjdi 269 2 ( ( -LRB- cord-252725-e3pazjdi 269 3 5,7,3′,4′-tetrahydroxyflavanone 5,7,3′,4′-tetrahydroxyflavanone CD cord-252725-e3pazjdi 269 4 ) ) -RRB- cord-252725-e3pazjdi 270 1 ( ( -LRB- cord-252725-e3pazjdi 270 2 Fig Fig NNP cord-252725-e3pazjdi 270 3 . . . cord-252725-e3pazjdi 270 4 19 19 CD cord-252725-e3pazjdi 270 5 ) ) -RRB- cord-252725-e3pazjdi 270 6 , , , cord-252725-e3pazjdi 270 7 is be VBZ cord-252725-e3pazjdi 270 8 a a DT cord-252725-e3pazjdi 270 9 natural natural JJ cord-252725-e3pazjdi 270 10 flavonoid flavonoid NN cord-252725-e3pazjdi 270 11 isolated isolate VBN cord-252725-e3pazjdi 270 12 mainly mainly RB cord-252725-e3pazjdi 270 13 from from IN cord-252725-e3pazjdi 270 14 Lyonia Lyonia NNP cord-252725-e3pazjdi 270 15 ovalifolia ovalifolia NNP cord-252725-e3pazjdi 270 16 and and CC cord-252725-e3pazjdi 270 17 Yerba Yerba NNP cord-252725-e3pazjdi 270 18 Santa Santa NNP cord-252725-e3pazjdi 270 19 ( ( -LRB- cord-252725-e3pazjdi 270 20 Eriodictyon Eriodictyon NNP cord-252725-e3pazjdi 270 21 californicum californicum NN cord-252725-e3pazjdi 270 22 ) ) -RRB- cord-252725-e3pazjdi 270 23 . . . cord-252725-e3pazjdi 271 1 Eriodictyol Eriodictyol NNP cord-252725-e3pazjdi 271 2 is be VBZ cord-252725-e3pazjdi 271 3 also also RB cord-252725-e3pazjdi 271 4 detected detect VBN cord-252725-e3pazjdi 271 5 in in IN cord-252725-e3pazjdi 271 6 some some DT cord-252725-e3pazjdi 271 7 plants plant NNS cord-252725-e3pazjdi 271 8 of of IN cord-252725-e3pazjdi 271 9 the the DT cord-252725-e3pazjdi 271 10 Lamiaceae Lamiaceae NNP cord-252725-e3pazjdi 271 11 family family NN cord-252725-e3pazjdi 271 12 , , , cord-252725-e3pazjdi 271 13 such such JJ cord-252725-e3pazjdi 271 14 as as IN cord-252725-e3pazjdi 271 15 peppermint peppermint NN cord-252725-e3pazjdi 271 16 ( ( -LRB- cord-252725-e3pazjdi 271 17 Mentha Mentha NNP cord-252725-e3pazjdi 271 18 piperita piperita NNP cord-252725-e3pazjdi 271 19 ) ) -RRB- cord-252725-e3pazjdi 271 20 , , , cord-252725-e3pazjdi 271 21 oregano oregano NN cord-252725-e3pazjdi 271 22 ( ( -LRB- cord-252725-e3pazjdi 271 23 Origanum Origanum NNP cord-252725-e3pazjdi 271 24 vulgare vulgare NNP cord-252725-e3pazjdi 271 25 ) ) -RRB- cord-252725-e3pazjdi 271 26 , , , cord-252725-e3pazjdi 271 27 and and CC cord-252725-e3pazjdi 271 28 thyme thyme NNS cord-252725-e3pazjdi 271 29 ( ( -LRB- cord-252725-e3pazjdi 271 30 Thymus thymus NN cord-252725-e3pazjdi 271 31 vulgaris vulgaris NN cord-252725-e3pazjdi 271 32 ) ) -RRB- cord-252725-e3pazjdi 272 1 and and CC cord-252725-e3pazjdi 272 2 it -PRON- PRP cord-252725-e3pazjdi 272 3 is be VBZ cord-252725-e3pazjdi 272 4 ubiquitous ubiquitous JJ cord-252725-e3pazjdi 272 5 in in IN cord-252725-e3pazjdi 272 6 fruits fruit NNS cord-252725-e3pazjdi 272 7 , , , cord-252725-e3pazjdi 272 8 vegetables vegetable NNS cord-252725-e3pazjdi 272 9 , , , cord-252725-e3pazjdi 272 10 including include VBG cord-252725-e3pazjdi 272 11 tomatoes tomato NNS cord-252725-e3pazjdi 272 12 , , , cord-252725-e3pazjdi 272 13 mint mint NN cord-252725-e3pazjdi 272 14 , , , cord-252725-e3pazjdi 272 15 grapefruit grapefruit NN cord-252725-e3pazjdi 272 16 , , , cord-252725-e3pazjdi 272 17 oranges orange NNS cord-252725-e3pazjdi 272 18 , , , cord-252725-e3pazjdi 272 19 and and CC cord-252725-e3pazjdi 272 20 lemons lemon NNS cord-252725-e3pazjdi 272 21 as as RB cord-252725-e3pazjdi 272 22 well well RB cord-252725-e3pazjdi 272 23 as as IN cord-252725-e3pazjdi 272 24 in in IN cord-252725-e3pazjdi 272 25 several several JJ cord-252725-e3pazjdi 272 26 medicinal medicinal JJ cord-252725-e3pazjdi 272 27 plants plant NNS cord-252725-e3pazjdi 272 28 such such JJ cord-252725-e3pazjdi 272 29 as as IN cord-252725-e3pazjdi 272 30 Bauhinia Bauhinia NNP cord-252725-e3pazjdi 272 31 ungulata ungulata NN cord-252725-e3pazjdi 272 32 , , , cord-252725-e3pazjdi 272 33 Arcytophyllum Arcytophyllum NNP cord-252725-e3pazjdi 272 34 thymifolium thymifolium NN cord-252725-e3pazjdi 272 35 , , , cord-252725-e3pazjdi 272 36 Elsholtzia Elsholtzia NNP cord-252725-e3pazjdi 272 37 bodinieri bodinieri NN cord-252725-e3pazjdi 272 38 , , , cord-252725-e3pazjdi 272 39 and and CC cord-252725-e3pazjdi 272 40 Clinopodium Clinopodium NNP cord-252725-e3pazjdi 272 41 chinense chinense NN cord-252725-e3pazjdi 272 42 [ [ -LRB- cord-252725-e3pazjdi 272 43 188 188 CD cord-252725-e3pazjdi 272 44 , , , cord-252725-e3pazjdi 272 45 189 189 CD cord-252725-e3pazjdi 272 46 ] ] -RRB- cord-252725-e3pazjdi 272 47 . . . cord-252725-e3pazjdi 273 1 Several several JJ cord-252725-e3pazjdi 273 2 studies study NNS cord-252725-e3pazjdi 273 3 have have VBP cord-252725-e3pazjdi 273 4 revealed reveal VBN cord-252725-e3pazjdi 273 5 that that IN cord-252725-e3pazjdi 273 6 eriodictyol eriodictyol NNP cord-252725-e3pazjdi 273 7 possesses possess VBZ cord-252725-e3pazjdi 273 8 several several JJ cord-252725-e3pazjdi 273 9 bioactivities bioactivitie NNS cord-252725-e3pazjdi 273 10 , , , cord-252725-e3pazjdi 273 11 including include VBG cord-252725-e3pazjdi 273 12 anti anti JJ cord-252725-e3pazjdi 273 13 - - JJ cord-252725-e3pazjdi 273 14 inflammation inflammation JJ cord-252725-e3pazjdi 273 15 , , , cord-252725-e3pazjdi 273 16 anti anti JJ cord-252725-e3pazjdi 273 17 - - JJ cord-252725-e3pazjdi 273 18 oxidation oxidation JJ cord-252725-e3pazjdi 273 19 , , , cord-252725-e3pazjdi 273 20 antimicrobial antimicrobial NN cord-252725-e3pazjdi 273 21 , , , cord-252725-e3pazjdi 273 22 anticancer anticancer JJ cord-252725-e3pazjdi 273 23 , , , cord-252725-e3pazjdi 273 24 protective protective JJ cord-252725-e3pazjdi 273 25 effects effect NNS cord-252725-e3pazjdi 273 26 on on IN cord-252725-e3pazjdi 273 27 the the DT cord-252725-e3pazjdi 273 28 neurons neuron NNS cord-252725-e3pazjdi 273 29 , , , cord-252725-e3pazjdi 273 30 kidneys kidney NNS cord-252725-e3pazjdi 273 31 , , , cord-252725-e3pazjdi 273 32 and and CC cord-252725-e3pazjdi 273 33 lungs lung NNS cord-252725-e3pazjdi 273 34 , , , cord-252725-e3pazjdi 273 35 insulin insulin NN cord-252725-e3pazjdi 273 36 secretagogue secretagogue NN cord-252725-e3pazjdi 273 37 and and CC cord-252725-e3pazjdi 273 38 antidiabetic antidiabetic JJ cord-252725-e3pazjdi 273 39 properties property NNS cord-252725-e3pazjdi 273 40 [ [ -LRB- cord-252725-e3pazjdi 273 41 190 190 CD cord-252725-e3pazjdi 273 42 , , , cord-252725-e3pazjdi 273 43 191 191 CD cord-252725-e3pazjdi 273 44 ] ] -RRB- cord-252725-e3pazjdi 273 45 . . . cord-252725-e3pazjdi 274 1 Furthermore furthermore RB cord-252725-e3pazjdi 274 2 , , , cord-252725-e3pazjdi 274 3 several several JJ cord-252725-e3pazjdi 274 4 studies study NNS cord-252725-e3pazjdi 274 5 have have VBP cord-252725-e3pazjdi 274 6 shown show VBN cord-252725-e3pazjdi 274 7 that that IN cord-252725-e3pazjdi 274 8 eriodictyol eriodictyol NNP cord-252725-e3pazjdi 274 9 exerts exert VBZ cord-252725-e3pazjdi 274 10 its -PRON- PRP$ cord-252725-e3pazjdi 274 11 anti anti JJ cord-252725-e3pazjdi 274 12 - - JJ cord-252725-e3pazjdi 274 13 inflammatory inflammatory JJ cord-252725-e3pazjdi 274 14 and and CC cord-252725-e3pazjdi 274 15 antioxidant antioxidant JJ cord-252725-e3pazjdi 274 16 effects effect NNS cord-252725-e3pazjdi 274 17 through through IN cord-252725-e3pazjdi 274 18 Akt Akt NNP cord-252725-e3pazjdi 274 19 / / SYM cord-252725-e3pazjdi 274 20 NF NF NNP cord-252725-e3pazjdi 274 21 - - HYPH cord-252725-e3pazjdi 274 22 κB κB NNP cord-252725-e3pazjdi 274 23 - - HYPH cord-252725-e3pazjdi 274 24 related relate VBN cord-252725-e3pazjdi 274 25 signaling signal VBG cord-252725-e3pazjdi 274 26 pathways pathway NNS cord-252725-e3pazjdi 274 27 [ [ -LRB- cord-252725-e3pazjdi 274 28 192 192 CD cord-252725-e3pazjdi 274 29 ] ] -RRB- cord-252725-e3pazjdi 274 30 . . . cord-252725-e3pazjdi 275 1 Eriodictyol Eriodictyol NNP cord-252725-e3pazjdi 275 2 has have VBZ cord-252725-e3pazjdi 275 3 immunomodulatory immunomodulatory JJ cord-252725-e3pazjdi 275 4 effects effect NNS cord-252725-e3pazjdi 275 5 , , , cord-252725-e3pazjdi 275 6 comprising comprise VBG cord-252725-e3pazjdi 275 7 inhibition inhibition NN cord-252725-e3pazjdi 275 8 of of IN cord-252725-e3pazjdi 275 9 nitric nitric NN cord-252725-e3pazjdi 275 10 oxide oxide NN cord-252725-e3pazjdi 275 11 ( ( -LRB- cord-252725-e3pazjdi 275 12 NO no UH cord-252725-e3pazjdi 275 13 ) ) -RRB- cord-252725-e3pazjdi 275 14 production production NN cord-252725-e3pazjdi 275 15 by by IN cord-252725-e3pazjdi 275 16 blockage blockage NN cord-252725-e3pazjdi 275 17 of of IN cord-252725-e3pazjdi 275 18 NF nf NN cord-252725-e3pazjdi 275 19 - - HYPH cord-252725-e3pazjdi 275 20 κB κb CD cord-252725-e3pazjdi 275 21 activation activation NN cord-252725-e3pazjdi 275 22 and and CC cord-252725-e3pazjdi 275 23 phosphorylation phosphorylation NN cord-252725-e3pazjdi 275 24 of of IN cord-252725-e3pazjdi 275 25 p38 p38 CD cord-252725-e3pazjdi 275 26 , , , cord-252725-e3pazjdi 275 27 MAPK MAPK NNP cord-252725-e3pazjdi 275 28 , , , cord-252725-e3pazjdi 275 29 extracellular extracellular JJ cord-252725-e3pazjdi 275 30 signal signal NN cord-252725-e3pazjdi 275 31 - - HYPH cord-252725-e3pazjdi 275 32 regulated regulate VBN cord-252725-e3pazjdi 275 33 kinase kinase NN cord-252725-e3pazjdi 275 34 1 1 CD cord-252725-e3pazjdi 275 35 and and CC cord-252725-e3pazjdi 275 36 2 2 CD cord-252725-e3pazjdi 275 37 ( ( -LRB- cord-252725-e3pazjdi 275 38 ERK1 ERK1 NNP cord-252725-e3pazjdi 275 39 and and CC cord-252725-e3pazjdi 275 40 2 2 CD cord-252725-e3pazjdi 275 41 ) ) -RRB- cord-252725-e3pazjdi 275 42 , , , cord-252725-e3pazjdi 275 43 JNK JNK NNP cord-252725-e3pazjdi 275 44 and and CC cord-252725-e3pazjdi 275 45 COX-2 COX-2 NNP cord-252725-e3pazjdi 275 46 in in IN cord-252725-e3pazjdi 275 47 lipopolysaccharide lipopolysaccharide NN cord-252725-e3pazjdi 275 48 ( ( -LRB- cord-252725-e3pazjdi 275 49 LPS)-induced lps)-induced JJ cord-252725-e3pazjdi 275 50 inflammatory inflammatory JJ cord-252725-e3pazjdi 275 51 responses response NNS cord-252725-e3pazjdi 275 52 in in IN cord-252725-e3pazjdi 275 53 macrophages macrophage NNS cord-252725-e3pazjdi 275 54 [ [ -LRB- cord-252725-e3pazjdi 275 55 193 193 CD cord-252725-e3pazjdi 275 56 ] ] -RRB- cord-252725-e3pazjdi 275 57 . . . cord-252725-e3pazjdi 276 1 Moreover moreover RB cord-252725-e3pazjdi 276 2 , , , cord-252725-e3pazjdi 276 3 a a DT cord-252725-e3pazjdi 276 4 study study NN cord-252725-e3pazjdi 276 5 demonstrated demonstrate VBD cord-252725-e3pazjdi 276 6 that that IN cord-252725-e3pazjdi 276 7 eriodictyol eriodictyol NNP cord-252725-e3pazjdi 276 8 could could MD cord-252725-e3pazjdi 276 9 alleviate alleviate VB cord-252725-e3pazjdi 276 10 the the DT cord-252725-e3pazjdi 276 11 LPS LPS NNP cord-252725-e3pazjdi 276 12 - - HYPH cord-252725-e3pazjdi 276 13 induced induce VBN cord-252725-e3pazjdi 276 14 lung lung NN cord-252725-e3pazjdi 276 15 injury injury NN cord-252725-e3pazjdi 276 16 in in IN cord-252725-e3pazjdi 276 17 mice mouse NNS cord-252725-e3pazjdi 276 18 by by IN cord-252725-e3pazjdi 276 19 regulating regulate VBG cord-252725-e3pazjdi 276 20 the the DT cord-252725-e3pazjdi 276 21 Nrf2 Nrf2 NNP cord-252725-e3pazjdi 276 22 pathway pathway NN cord-252725-e3pazjdi 276 23 and and CC cord-252725-e3pazjdi 276 24 inhibiting inhibit VBG cord-252725-e3pazjdi 276 25 the the DT cord-252725-e3pazjdi 276 26 expression expression NN cord-252725-e3pazjdi 276 27 of of IN cord-252725-e3pazjdi 276 28 inflammatory inflammatory JJ cord-252725-e3pazjdi 276 29 cytokines cytokine NNS cord-252725-e3pazjdi 276 30 in in IN cord-252725-e3pazjdi 276 31 macrophages macrophage NNS cord-252725-e3pazjdi 276 32 such such JJ cord-252725-e3pazjdi 276 33 as as IN cord-252725-e3pazjdi 276 34 TNF TNF NNP cord-252725-e3pazjdi 276 35 - - HYPH cord-252725-e3pazjdi 276 36 α α NNP cord-252725-e3pazjdi 276 37 , , , cord-252725-e3pazjdi 276 38 IL-6 IL-6 NNP cord-252725-e3pazjdi 276 39 , , , cord-252725-e3pazjdi 276 40 IL-1β IL-1β NNP cord-252725-e3pazjdi 276 41 and and CC cord-252725-e3pazjdi 276 42 MIP-2 MIP-2 NNP cord-252725-e3pazjdi 276 43 , , , cord-252725-e3pazjdi 276 44 suggesting suggest VBG cord-252725-e3pazjdi 276 45 that that IN cord-252725-e3pazjdi 276 46 eriodictyol eriodictyol NNP cord-252725-e3pazjdi 276 47 may may MD cord-252725-e3pazjdi 276 48 be be VB cord-252725-e3pazjdi 276 49 used use VBN cord-252725-e3pazjdi 276 50 as as IN cord-252725-e3pazjdi 276 51 a a DT cord-252725-e3pazjdi 276 52 drug drug NN cord-252725-e3pazjdi 276 53 for for IN cord-252725-e3pazjdi 276 54 the the DT cord-252725-e3pazjdi 276 55 treatment treatment NN cord-252725-e3pazjdi 276 56 of of IN cord-252725-e3pazjdi 276 57 LPS LPS NNP cord-252725-e3pazjdi 276 58 - - HYPH cord-252725-e3pazjdi 276 59 induced induce VBN cord-252725-e3pazjdi 276 60 lung lung NN cord-252725-e3pazjdi 276 61 injury injury NN cord-252725-e3pazjdi 276 62 . . . cord-252725-e3pazjdi 277 1 In in IN cord-252725-e3pazjdi 277 2 addition addition NN cord-252725-e3pazjdi 277 3 , , , cord-252725-e3pazjdi 277 4 its -PRON- PRP$ cord-252725-e3pazjdi 277 5 anti anti JJ cord-252725-e3pazjdi 277 6 - - JJ cord-252725-e3pazjdi 277 7 inflammatory inflammatory JJ cord-252725-e3pazjdi 277 8 and and CC cord-252725-e3pazjdi 277 9 anti anti JJ cord-252725-e3pazjdi 277 10 - - JJ cord-252725-e3pazjdi 277 11 oxidative oxidative JJ cord-252725-e3pazjdi 277 12 capacities capacity NNS cord-252725-e3pazjdi 277 13 have have VBP cord-252725-e3pazjdi 277 14 drained drain VBN cord-252725-e3pazjdi 277 15 attention attention NN cord-252725-e3pazjdi 277 16 to to IN cord-252725-e3pazjdi 277 17 its -PRON- PRP$ cord-252725-e3pazjdi 277 18 therapeutic therapeutic JJ cord-252725-e3pazjdi 277 19 potential potential NN cord-252725-e3pazjdi 277 20 , , , cord-252725-e3pazjdi 277 21 especially especially RB cord-252725-e3pazjdi 277 22 , , , cord-252725-e3pazjdi 277 23 for for IN cord-252725-e3pazjdi 277 24 asthma asthma NN cord-252725-e3pazjdi 277 25 and and CC cord-252725-e3pazjdi 277 26 treating treat VBG cord-252725-e3pazjdi 277 27 colds cold NNS cord-252725-e3pazjdi 277 28 [ [ -LRB- cord-252725-e3pazjdi 277 29 194 194 CD cord-252725-e3pazjdi 277 30 , , , cord-252725-e3pazjdi 277 31 195 195 CD cord-252725-e3pazjdi 277 32 ] ] -RRB- cord-252725-e3pazjdi 277 33 . . . cord-252725-e3pazjdi 278 1 A a DT cord-252725-e3pazjdi 278 2 recent recent JJ cord-252725-e3pazjdi 278 3 study study NN cord-252725-e3pazjdi 278 4 has have VBZ cord-252725-e3pazjdi 278 5 reported report VBN cord-252725-e3pazjdi 278 6 that that IN cord-252725-e3pazjdi 278 7 ( ( -LRB- cord-252725-e3pazjdi 278 8 2S)-eriodictyol 2S)-eriodictyol NNP cord-252725-e3pazjdi 278 9 7-O-(6″-O 7-o-(6″-o CD cord-252725-e3pazjdi 278 10 - - HYPH cord-252725-e3pazjdi 278 11 galloyl)-beta galloyl)-beta NN cord-252725-e3pazjdi 278 12 - - HYPH cord-252725-e3pazjdi 278 13 D d NN cord-252725-e3pazjdi 278 14 - - HYPH cord-252725-e3pazjdi 278 15 glucopyranoside glucopyranoside NN cord-252725-e3pazjdi 278 16 , , , cord-252725-e3pazjdi 278 17 aneriodictyol aneriodictyol JJ cord-252725-e3pazjdi 278 18 derivative derivative NN cord-252725-e3pazjdi 278 19 , , , cord-252725-e3pazjdi 278 20 ranked rank VBD cord-252725-e3pazjdi 278 21 as as IN cord-252725-e3pazjdi 278 22 an an DT cord-252725-e3pazjdi 278 23 inhibitor inhibitor NN cord-252725-e3pazjdi 278 24 against against IN cord-252725-e3pazjdi 278 25 SARS SARS NNP cord-252725-e3pazjdi 278 26 - - HYPH cord-252725-e3pazjdi 278 27 CoV-2 CoV-2 NNP cord-252725-e3pazjdi 278 28 3CLpro 3clpro CD cord-252725-e3pazjdi 278 29 receptor receptor NN cord-252725-e3pazjdi 278 30 binding binding NN cord-252725-e3pazjdi 278 31 site site NN cord-252725-e3pazjdi 278 32 and and CC cord-252725-e3pazjdi 278 33 catalytic catalytic JJ cord-252725-e3pazjdi 278 34 dyad dyad NN cord-252725-e3pazjdi 278 35 ( ( -LRB- cord-252725-e3pazjdi 278 36 Cys-145 Cys-145 NNP cord-252725-e3pazjdi 278 37 and and CC cord-252725-e3pazjdi 278 38 His-41 His-41 NNP cord-252725-e3pazjdi 278 39 ) ) -RRB- cord-252725-e3pazjdi 278 40 of of IN cord-252725-e3pazjdi 278 41 SARS SARS NNP cord-252725-e3pazjdi 278 42 - - HYPH cord-252725-e3pazjdi 278 43 CoV-2 CoV-2 NNP cord-252725-e3pazjdi 278 44 3CLpro 3clpro CD cord-252725-e3pazjdi 278 45 [ [ -LRB- cord-252725-e3pazjdi 278 46 196 196 CD cord-252725-e3pazjdi 278 47 ] ] -RRB- cord-252725-e3pazjdi 278 48 . . . cord-252725-e3pazjdi 279 1 A a DT cord-252725-e3pazjdi 279 2 recent recent JJ cord-252725-e3pazjdi 279 3 docking docking NN cord-252725-e3pazjdi 279 4 study study NN cord-252725-e3pazjdi 279 5 has have VBZ cord-252725-e3pazjdi 279 6 ranked rank VBN cord-252725-e3pazjdi 279 7 Eriodictyol Eriodictyol NNP cord-252725-e3pazjdi 279 8 among among IN cord-252725-e3pazjdi 279 9 other other JJ cord-252725-e3pazjdi 279 10 compounds compound NNS cord-252725-e3pazjdi 279 11 to to TO cord-252725-e3pazjdi 279 12 be be VB cord-252725-e3pazjdi 279 13 tested test VBN cord-252725-e3pazjdi 279 14 experimentally experimentally RB cord-252725-e3pazjdi 279 15 as as IN cord-252725-e3pazjdi 279 16 an an DT cord-252725-e3pazjdi 279 17 inhibitor inhibitor NN cord-252725-e3pazjdi 279 18 of of IN cord-252725-e3pazjdi 279 19 ACE2 ACE2 NNP cord-252725-e3pazjdi 279 20 receptor receptor NN cord-252725-e3pazjdi 279 21 of of IN cord-252725-e3pazjdi 279 22 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 279 23 [ [ -LRB- cord-252725-e3pazjdi 279 24 197 197 CD cord-252725-e3pazjdi 279 25 ] ] -RRB- cord-252725-e3pazjdi 279 26 . . . cord-252725-e3pazjdi 280 1 These these DT cord-252725-e3pazjdi 280 2 studies study NNS cord-252725-e3pazjdi 280 3 suggested suggest VBD cord-252725-e3pazjdi 280 4 that that IN cord-252725-e3pazjdi 280 5 natural natural JJ cord-252725-e3pazjdi 280 6 products product NNS cord-252725-e3pazjdi 280 7 such such JJ cord-252725-e3pazjdi 280 8 as as IN cord-252725-e3pazjdi 280 9 Eriodictyol Eriodictyol NNP cord-252725-e3pazjdi 280 10 may may MD cord-252725-e3pazjdi 280 11 prove prove VB cord-252725-e3pazjdi 280 12 more more RBR cord-252725-e3pazjdi 280 13 useful useful JJ cord-252725-e3pazjdi 280 14 candidates candidate NNS cord-252725-e3pazjdi 280 15 for for IN cord-252725-e3pazjdi 280 16 COVID-19 covid-19 JJ cord-252725-e3pazjdi 280 17 drug drug NN cord-252725-e3pazjdi 280 18 therapy therapy NN cord-252725-e3pazjdi 280 19 . . . cord-252725-e3pazjdi 281 1 Syringic syringic NN cord-252725-e3pazjdi 281 2 acid acid NN cord-252725-e3pazjdi 281 3 ( ( -LRB- cord-252725-e3pazjdi 281 4 4-hydroxy-3,5-dimethoxybenzoicacid 4-hydroxy-3,5-dimethoxybenzoicacid CD cord-252725-e3pazjdi 281 5 ) ) -RRB- cord-252725-e3pazjdi 282 1 ( ( -LRB- cord-252725-e3pazjdi 282 2 Fig Fig NNP cord-252725-e3pazjdi 282 3 . . . cord-252725-e3pazjdi 282 4 20 20 CD cord-252725-e3pazjdi 282 5 ) ) -RRB- cord-252725-e3pazjdi 282 6 , , , cord-252725-e3pazjdi 282 7 is be VBZ cord-252725-e3pazjdi 282 8 a a DT cord-252725-e3pazjdi 282 9 phenolic phenolic JJ cord-252725-e3pazjdi 282 10 acid acid NN cord-252725-e3pazjdi 282 11 found find VBN cord-252725-e3pazjdi 282 12 in in IN cord-252725-e3pazjdi 282 13 many many JJ cord-252725-e3pazjdi 282 14 plants plant NNS cord-252725-e3pazjdi 282 15 and and CC cord-252725-e3pazjdi 282 16 dry dry JJ cord-252725-e3pazjdi 282 17 fruits fruit NNS cord-252725-e3pazjdi 282 18 such such JJ cord-252725-e3pazjdi 282 19 as as IN cord-252725-e3pazjdi 282 20 , , , cord-252725-e3pazjdi 282 21 dates date NNS cord-252725-e3pazjdi 282 22 and and CC cord-252725-e3pazjdi 282 23 walnuts walnut NNS cord-252725-e3pazjdi 282 24 , , , cord-252725-e3pazjdi 282 25 olives olive NNS cord-252725-e3pazjdi 282 26 , , , cord-252725-e3pazjdi 282 27 spices spice NNS cord-252725-e3pazjdi 282 28 , , , cord-252725-e3pazjdi 282 29 pumpkin pumpkin NN cord-252725-e3pazjdi 282 30 , , , cord-252725-e3pazjdi 282 31 grapes grape NNS cord-252725-e3pazjdi 282 32 , , , cord-252725-e3pazjdi 282 33 acai acai JJ cord-252725-e3pazjdi 282 34 palm palm NN cord-252725-e3pazjdi 282 35 , , , cord-252725-e3pazjdi 282 36 honey honey NN cord-252725-e3pazjdi 282 37 , , , cord-252725-e3pazjdi 282 38 red red JJ cord-252725-e3pazjdi 282 39 wine wine NN cord-252725-e3pazjdi 282 40 ; ; : cord-252725-e3pazjdi 282 41 cereals cereal NNS cord-252725-e3pazjdi 282 42 and and CC cord-252725-e3pazjdi 282 43 other other JJ cord-252725-e3pazjdi 282 44 plants plant NNS cord-252725-e3pazjdi 282 45 such such JJ cord-252725-e3pazjdi 282 46 as as IN cord-252725-e3pazjdi 282 47 gall gall NN cord-252725-e3pazjdi 282 48 trees tree NNS cord-252725-e3pazjdi 282 49 , , , cord-252725-e3pazjdi 282 50 proso proso NN cord-252725-e3pazjdi 282 51 millet millet NN cord-252725-e3pazjdi 282 52 , , , cord-252725-e3pazjdi 282 53 radish radish NN cord-252725-e3pazjdi 282 54 , , , cord-252725-e3pazjdi 282 55 chard chard NN cord-252725-e3pazjdi 282 56 and and CC cord-252725-e3pazjdi 282 57 sugar sugar NN cord-252725-e3pazjdi 282 58 apple apple NN cord-252725-e3pazjdi 282 59 [ [ -LRB- cord-252725-e3pazjdi 282 60 198 198 CD cord-252725-e3pazjdi 282 61 , , , cord-252725-e3pazjdi 282 62 199 199 CD cord-252725-e3pazjdi 282 63 ] ] -RRB- cord-252725-e3pazjdi 282 64 . . . cord-252725-e3pazjdi 283 1 Syringic syringic NN cord-252725-e3pazjdi 283 2 acid acid NN cord-252725-e3pazjdi 283 3 exhibits exhibit VBZ cord-252725-e3pazjdi 283 4 several several JJ cord-252725-e3pazjdi 283 5 positive positive JJ cord-252725-e3pazjdi 283 6 effects effect NNS cord-252725-e3pazjdi 283 7 on on IN cord-252725-e3pazjdi 283 8 human human JJ cord-252725-e3pazjdi 283 9 health health NN cord-252725-e3pazjdi 283 10 including include VBG cord-252725-e3pazjdi 283 11 anti anti JJ cord-252725-e3pazjdi 283 12 - - JJ cord-252725-e3pazjdi 283 13 diabetic diabetic JJ cord-252725-e3pazjdi 283 14 , , , cord-252725-e3pazjdi 283 15 hepato hepato JJ cord-252725-e3pazjdi 283 16 - - HYPH cord-252725-e3pazjdi 283 17 protective protective JJ cord-252725-e3pazjdi 283 18 , , , cord-252725-e3pazjdi 283 19 anti anti JJ cord-252725-e3pazjdi 283 20 - - JJ cord-252725-e3pazjdi 283 21 oxidant oxidant JJ cord-252725-e3pazjdi 283 22 , , , cord-252725-e3pazjdi 283 23 anti anti JJ cord-252725-e3pazjdi 283 24 - - JJ cord-252725-e3pazjdi 283 25 endotoxic endotoxic JJ cord-252725-e3pazjdi 283 26 , , , cord-252725-e3pazjdi 283 27 anti anti JJ cord-252725-e3pazjdi 283 28 - - JJ cord-252725-e3pazjdi 283 29 steatotic steatotic JJ cord-252725-e3pazjdi 283 30 , , , cord-252725-e3pazjdi 283 31 anti anti JJ cord-252725-e3pazjdi 283 32 - - JJ cord-252725-e3pazjdi 283 33 inflammatory inflammatory JJ cord-252725-e3pazjdi 283 34 , , , cord-252725-e3pazjdi 283 35 anti anti JJ cord-252725-e3pazjdi 283 36 - - JJ cord-252725-e3pazjdi 283 37 hypertensive hypertensive JJ cord-252725-e3pazjdi 283 38 , , , cord-252725-e3pazjdi 283 39 neuro neuro JJ cord-252725-e3pazjdi 283 40 - - HYPH cord-252725-e3pazjdi 283 41 protective protective JJ cord-252725-e3pazjdi 283 42 , , , cord-252725-e3pazjdi 283 43 anti anti JJ cord-252725-e3pazjdi 283 44 - - JJ cord-252725-e3pazjdi 283 45 cancer cancer JJ cord-252725-e3pazjdi 283 46 and and CC cord-252725-e3pazjdi 283 47 cardio cardio NN cord-252725-e3pazjdi 283 48 - - HYPH cord-252725-e3pazjdi 283 49 protection protection NN cord-252725-e3pazjdi 283 50 activities activity NNS cord-252725-e3pazjdi 283 51 [ [ -LRB- cord-252725-e3pazjdi 283 52 198 198 CD cord-252725-e3pazjdi 283 53 ] ] -RRB- cord-252725-e3pazjdi 283 54 [ [ -LRB- cord-252725-e3pazjdi 283 55 199 199 CD cord-252725-e3pazjdi 283 56 ] ] -RRB- cord-252725-e3pazjdi 283 57 [ [ -LRB- cord-252725-e3pazjdi 283 58 200 200 CD cord-252725-e3pazjdi 283 59 ] ] -RRB- cord-252725-e3pazjdi 283 60 . . . cord-252725-e3pazjdi 284 1 In in IN cord-252725-e3pazjdi 284 2 fact fact NN cord-252725-e3pazjdi 284 3 , , , cord-252725-e3pazjdi 284 4 syringic syringic JJ cord-252725-e3pazjdi 284 5 acid acid NN cord-252725-e3pazjdi 284 6 possesses possess VBZ cord-252725-e3pazjdi 284 7 these these DT cord-252725-e3pazjdi 284 8 beneficial beneficial JJ cord-252725-e3pazjdi 284 9 effects effect NNS cord-252725-e3pazjdi 284 10 on on IN cord-252725-e3pazjdi 284 11 human human JJ cord-252725-e3pazjdi 284 12 health health NN cord-252725-e3pazjdi 284 13 due due IN cord-252725-e3pazjdi 284 14 to to IN cord-252725-e3pazjdi 284 15 its -PRON- PRP$ cord-252725-e3pazjdi 284 16 strong strong JJ cord-252725-e3pazjdi 284 17 anti anti JJ cord-252725-e3pazjdi 284 18 - - JJ cord-252725-e3pazjdi 284 19 oxidant oxidant JJ cord-252725-e3pazjdi 284 20 nature nature NN cord-252725-e3pazjdi 284 21 . . . cord-252725-e3pazjdi 285 1 Syringic syringic NN cord-252725-e3pazjdi 285 2 acid acid NN cord-252725-e3pazjdi 285 3 exerts exert VBZ cord-252725-e3pazjdi 285 4 its -PRON- PRP$ cord-252725-e3pazjdi 285 5 activities activity NNS cord-252725-e3pazjdi 285 6 via via IN cord-252725-e3pazjdi 285 7 modulation modulation NN cord-252725-e3pazjdi 285 8 of of IN cord-252725-e3pazjdi 285 9 several several JJ cord-252725-e3pazjdi 285 10 molecules molecule NNS cord-252725-e3pazjdi 285 11 involved involve VBN cord-252725-e3pazjdi 285 12 in in IN cord-252725-e3pazjdi 285 13 disease disease NN cord-252725-e3pazjdi 285 14 progression progression NN cord-252725-e3pazjdi 285 15 such such JJ cord-252725-e3pazjdi 285 16 as as IN cord-252725-e3pazjdi 285 17 proteins protein NNS cord-252725-e3pazjdi 285 18 , , , cord-252725-e3pazjdi 285 19 transcriptional transcriptional JJ cord-252725-e3pazjdi 285 20 factors factor NNS cord-252725-e3pazjdi 285 21 and and CC cord-252725-e3pazjdi 285 22 growth growth NN cord-252725-e3pazjdi 285 23 factors factor NNS cord-252725-e3pazjdi 285 24 [ [ -LRB- cord-252725-e3pazjdi 285 25 200 200 CD cord-252725-e3pazjdi 285 26 ] ] -RRB- cord-252725-e3pazjdi 285 27 . . . cord-252725-e3pazjdi 286 1 Syringic syringic NN cord-252725-e3pazjdi 286 2 acid acid NN cord-252725-e3pazjdi 286 3 identified identify VBN cord-252725-e3pazjdi 286 4 , , , cord-252725-e3pazjdi 286 5 with with IN cord-252725-e3pazjdi 286 6 other other JJ cord-252725-e3pazjdi 286 7 secondary secondary JJ cord-252725-e3pazjdi 286 8 metabolite metabolite JJ cord-252725-e3pazjdi 286 9 compounds compound NNS cord-252725-e3pazjdi 286 10 , , , cord-252725-e3pazjdi 286 11 in in IN cord-252725-e3pazjdi 286 12 extracts extract NNS cord-252725-e3pazjdi 286 13 of of IN cord-252725-e3pazjdi 286 14 stems stem NNS cord-252725-e3pazjdi 286 15 and and CC cord-252725-e3pazjdi 286 16 leaves leave NNS cord-252725-e3pazjdi 286 17 of of IN cord-252725-e3pazjdi 286 18 Bougain Bougain NNP cord-252725-e3pazjdi 286 19 villeam villeam NN cord-252725-e3pazjdi 286 20 , , , cord-252725-e3pazjdi 286 21 which which WDT cord-252725-e3pazjdi 286 22 it -PRON- PRP cord-252725-e3pazjdi 286 23 is be VBZ cord-252725-e3pazjdi 286 24 used use VBN cord-252725-e3pazjdi 286 25 as as IN cord-252725-e3pazjdi 286 26 a a DT cord-252725-e3pazjdi 286 27 tea tea NN cord-252725-e3pazjdi 286 28 for for IN cord-252725-e3pazjdi 286 29 easing ease VBG cord-252725-e3pazjdi 286 30 cough cough NN cord-252725-e3pazjdi 286 31 , , , cord-252725-e3pazjdi 286 32 fever fever NN cord-252725-e3pazjdi 286 33 , , , cord-252725-e3pazjdi 286 34 sore sore JJ cord-252725-e3pazjdi 286 35 and and CC cord-252725-e3pazjdi 286 36 diarrhea diarrhea NN cord-252725-e3pazjdi 286 37 besides besides IN cord-252725-e3pazjdi 286 38 its -PRON- PRP$ cord-252725-e3pazjdi 286 39 several several JJ cord-252725-e3pazjdi 286 40 beneficial beneficial JJ cord-252725-e3pazjdi 286 41 activities activity NNS cord-252725-e3pazjdi 286 42 such such JJ cord-252725-e3pazjdi 286 43 as as IN cord-252725-e3pazjdi 286 44 antioxidant antioxidant JJ cord-252725-e3pazjdi 286 45 , , , cord-252725-e3pazjdi 286 46 anticancer anticancer JJ cord-252725-e3pazjdi 286 47 , , , cord-252725-e3pazjdi 286 48 antibacterial antibacterial JJ cord-252725-e3pazjdi 286 49 , , , cord-252725-e3pazjdi 286 50 antiviral antiviral JJ cord-252725-e3pazjdi 286 51 [ [ -LRB- cord-252725-e3pazjdi 286 52 201 201 CD cord-252725-e3pazjdi 286 53 ] ] -RRB- cord-252725-e3pazjdi 286 54 . . . cord-252725-e3pazjdi 287 1 A a DT cord-252725-e3pazjdi 287 2 study study NN cord-252725-e3pazjdi 287 3 has have VBZ cord-252725-e3pazjdi 287 4 reported report VBN cord-252725-e3pazjdi 287 5 in in IN cord-252725-e3pazjdi 287 6 asthma asthma NN cord-252725-e3pazjdi 287 7 mice mice NN cord-252725-e3pazjdi 287 8 model model NN cord-252725-e3pazjdi 287 9 that that IN cord-252725-e3pazjdi 287 10 the the DT cord-252725-e3pazjdi 287 11 effect effect NN cord-252725-e3pazjdi 287 12 of of IN cord-252725-e3pazjdi 287 13 syringic syringic JJ cord-252725-e3pazjdi 287 14 acid acid NN cord-252725-e3pazjdi 287 15 is be VBZ cord-252725-e3pazjdi 287 16 prominent prominent JJ cord-252725-e3pazjdi 287 17 in in IN cord-252725-e3pazjdi 287 18 the the DT cord-252725-e3pazjdi 287 19 treatment treatment NN cord-252725-e3pazjdi 287 20 of of IN cord-252725-e3pazjdi 287 21 asthma asthma NN cord-252725-e3pazjdi 287 22 by by IN cord-252725-e3pazjdi 287 23 controlling control VBG cord-252725-e3pazjdi 287 24 the the DT cord-252725-e3pazjdi 287 25 accumulation accumulation NN cord-252725-e3pazjdi 287 26 of of IN cord-252725-e3pazjdi 287 27 inflammatory inflammatory JJ cord-252725-e3pazjdi 287 28 cells cell NNS cord-252725-e3pazjdi 287 29 , , , cord-252725-e3pazjdi 287 30 other other JJ cord-252725-e3pazjdi 287 31 inflammatory inflammatory JJ cord-252725-e3pazjdi 287 32 markers marker NNS cord-252725-e3pazjdi 287 33 such such JJ cord-252725-e3pazjdi 287 34 as as IN cord-252725-e3pazjdi 287 35 IL-4 IL-4 NNP cord-252725-e3pazjdi 287 36 , , , cord-252725-e3pazjdi 287 37 IL-5 IL-5 NNP cord-252725-e3pazjdi 287 38 , , , cord-252725-e3pazjdi 287 39 IL-13 IL-13 NNP cord-252725-e3pazjdi 287 40 , , , cord-252725-e3pazjdi 287 41 and and CC cord-252725-e3pazjdi 287 42 TNF TNF NNP cord-252725-e3pazjdi 287 43 - - HYPH cord-252725-e3pazjdi 287 44 α α NN cord-252725-e3pazjdi 287 45 along along RP cord-252725-e3pazjdi 287 46 with with IN cord-252725-e3pazjdi 287 47 enhancement enhancement NN cord-252725-e3pazjdi 287 48 of of IN cord-252725-e3pazjdi 287 49 antioxidant antioxidant JJ cord-252725-e3pazjdi 287 50 markers marker NNS cord-252725-e3pazjdi 287 51 , , , cord-252725-e3pazjdi 287 52 suppression suppression NN cord-252725-e3pazjdi 287 53 of of IN cord-252725-e3pazjdi 287 54 ROS ROS NNP cord-252725-e3pazjdi 287 55 and and CC cord-252725-e3pazjdi 287 56 controlling control VBG cord-252725-e3pazjdi 287 57 airway airway NNP cord-252725-e3pazjdi 287 58 hyper hyper NN cord-252725-e3pazjdi 287 59 - - NN cord-252725-e3pazjdi 287 60 reactivity reactivity NN cord-252725-e3pazjdi 287 61 . . . cord-252725-e3pazjdi 288 1 Therefore therefore RB cord-252725-e3pazjdi 288 2 , , , cord-252725-e3pazjdi 288 3 syringic syringic JJ cord-252725-e3pazjdi 288 4 acid acid NN cord-252725-e3pazjdi 288 5 may may MD cord-252725-e3pazjdi 288 6 be be VB cord-252725-e3pazjdi 288 7 recommended recommend VBN cord-252725-e3pazjdi 288 8 for for IN cord-252725-e3pazjdi 288 9 clinical clinical JJ cord-252725-e3pazjdi 288 10 trials trial NNS cord-252725-e3pazjdi 288 11 in in IN cord-252725-e3pazjdi 288 12 the the DT cord-252725-e3pazjdi 288 13 treatment treatment NN cord-252725-e3pazjdi 288 14 of of IN cord-252725-e3pazjdi 288 15 asthma asthma NN cord-252725-e3pazjdi 288 16 [ [ -LRB- cord-252725-e3pazjdi 288 17 202 202 CD cord-252725-e3pazjdi 288 18 ] ] -RRB- cord-252725-e3pazjdi 288 19 . . . cord-252725-e3pazjdi 289 1 Moreover moreover RB cord-252725-e3pazjdi 289 2 , , , cord-252725-e3pazjdi 289 3 syringic syringic JJ cord-252725-e3pazjdi 289 4 acid acid NN cord-252725-e3pazjdi 289 5 has have VBZ cord-252725-e3pazjdi 289 6 shown show VBN cord-252725-e3pazjdi 289 7 among among IN cord-252725-e3pazjdi 289 8 other other JJ cord-252725-e3pazjdi 289 9 compounds compound NNS cord-252725-e3pazjdi 289 10 , , , cord-252725-e3pazjdi 289 11 to to TO cord-252725-e3pazjdi 289 12 be be VB cord-252725-e3pazjdi 289 13 a a DT cord-252725-e3pazjdi 289 14 potent potent JJ cord-252725-e3pazjdi 289 15 inhibitor inhibitor NN cord-252725-e3pazjdi 289 16 against against IN cord-252725-e3pazjdi 289 17 H1N1 H1N1 NNP cord-252725-e3pazjdi 289 18 swine swine NN cord-252725-e3pazjdi 289 19 influenza influenza NN cord-252725-e3pazjdi 289 20 [ [ -LRB- cord-252725-e3pazjdi 289 21 203 203 CD cord-252725-e3pazjdi 289 22 ] ] -RRB- cord-252725-e3pazjdi 289 23 . . . cord-252725-e3pazjdi 290 1 Due due IN cord-252725-e3pazjdi 290 2 to to IN cord-252725-e3pazjdi 290 3 its -PRON- PRP$ cord-252725-e3pazjdi 290 4 strong strong JJ cord-252725-e3pazjdi 290 5 antioxidant antioxidant NN cord-252725-e3pazjdi 290 6 capacity capacity NN cord-252725-e3pazjdi 290 7 , , , cord-252725-e3pazjdi 290 8 synergic synergic JJ cord-252725-e3pazjdi 290 9 acid acid NN cord-252725-e3pazjdi 290 10 , , , cord-252725-e3pazjdi 290 11 may may MD cord-252725-e3pazjdi 290 12 be be VB cord-252725-e3pazjdi 290 13 used use VBN cord-252725-e3pazjdi 290 14 to to TO cord-252725-e3pazjdi 290 15 strengthen strengthen VB cord-252725-e3pazjdi 290 16 lung lung NN cord-252725-e3pazjdi 290 17 and and CC cord-252725-e3pazjdi 290 18 body body NN cord-252725-e3pazjdi 290 19 invulnerability invulnerability NN cord-252725-e3pazjdi 290 20 in in IN cord-252725-e3pazjdi 290 21 front front NN cord-252725-e3pazjdi 290 22 of of IN cord-252725-e3pazjdi 290 23 COVID-19 covid-19 JJ cord-252725-e3pazjdi 290 24 infections infection NNS cord-252725-e3pazjdi 290 25 . . . cord-252725-e3pazjdi 291 1 Polydatin Polydatin NNP cord-252725-e3pazjdi 291 2 ( ( -LRB- cord-252725-e3pazjdi 291 3 3,4′,5-trihydroxystilbene-3-β 3,4′,5-trihydroxystilbene-3-β CD cord-252725-e3pazjdi 291 4 - - HYPH cord-252725-e3pazjdi 291 5 D d NN cord-252725-e3pazjdi 291 6 - - HYPH cord-252725-e3pazjdi 291 7 glucoside glucoside NN cord-252725-e3pazjdi 291 8 ) ) -RRB- cord-252725-e3pazjdi 292 1 ( ( -LRB- cord-252725-e3pazjdi 292 2 Fig Fig NNP cord-252725-e3pazjdi 292 3 . . NNP cord-252725-e3pazjdi 292 4 21 21 CD cord-252725-e3pazjdi 292 5 ) ) -RRB- cord-252725-e3pazjdi 292 6 , , , cord-252725-e3pazjdi 292 7 also also RB cord-252725-e3pazjdi 292 8 named name VBN cord-252725-e3pazjdi 292 9 piceid piceid NNP cord-252725-e3pazjdi 292 10 is be VBZ cord-252725-e3pazjdi 292 11 a a DT cord-252725-e3pazjdi 292 12 natural natural JJ cord-252725-e3pazjdi 292 13 resveratrol resveratrol NN cord-252725-e3pazjdi 292 14 glucoside glucoside NN cord-252725-e3pazjdi 292 15 and and CC cord-252725-e3pazjdi 292 16 precursor precursor NN cord-252725-e3pazjdi 292 17 . . . cord-252725-e3pazjdi 293 1 Polydatin Polydatin NNP cord-252725-e3pazjdi 293 2 , , , cord-252725-e3pazjdi 293 3 an an DT cord-252725-e3pazjdi 293 4 active active JJ cord-252725-e3pazjdi 293 5 compound compound NN cord-252725-e3pazjdi 293 6 isolated isolate VBN cord-252725-e3pazjdi 293 7 from from IN cord-252725-e3pazjdi 293 8 the the DT cord-252725-e3pazjdi 293 9 root root NN cord-252725-e3pazjdi 293 10 of of IN cord-252725-e3pazjdi 293 11 Polygonumcus Polygonumcus NNP cord-252725-e3pazjdi 293 12 pidatum pidatum NN cord-252725-e3pazjdi 293 13 Sieb Sieb NNP cord-252725-e3pazjdi 293 14 . . . cord-252725-e3pazjdi 294 1 et et NNP cord-252725-e3pazjdi 294 2 Zucc Zucc NNP cord-252725-e3pazjdi 294 3 , , , cord-252725-e3pazjdi 294 4 has have VBZ cord-252725-e3pazjdi 294 5 been be VBN cord-252725-e3pazjdi 294 6 widely widely RB cord-252725-e3pazjdi 294 7 used use VBN cord-252725-e3pazjdi 294 8 for for IN cord-252725-e3pazjdi 294 9 treatment treatment NN cord-252725-e3pazjdi 294 10 of of IN cord-252725-e3pazjdi 294 11 hyperlipemia hyperlipemia NN cord-252725-e3pazjdi 294 12 , , , cord-252725-e3pazjdi 294 13 inflammation inflammation NN cord-252725-e3pazjdi 294 14 , , , cord-252725-e3pazjdi 294 15 infection infection NN cord-252725-e3pazjdi 294 16 and and CC cord-252725-e3pazjdi 294 17 cancer cancer NN cord-252725-e3pazjdi 294 18 , , , cord-252725-e3pazjdi 294 19 fever fever NN cord-252725-e3pazjdi 294 20 , , , cord-252725-e3pazjdi 294 21 cough cough NN cord-252725-e3pazjdi 294 22 , , , cord-252725-e3pazjdi 294 23 hypertension hypertension NN cord-252725-e3pazjdi 294 24 and and CC cord-252725-e3pazjdi 294 25 other other JJ cord-252725-e3pazjdi 294 26 pharmacological pharmacological JJ cord-252725-e3pazjdi 294 27 benefits benefit NNS cord-252725-e3pazjdi 294 28 . . . cord-252725-e3pazjdi 295 1 Polydatin Polydatin NNP cord-252725-e3pazjdi 295 2 is be VBZ cord-252725-e3pazjdi 295 3 also also RB cord-252725-e3pazjdi 295 4 detected detect VBN cord-252725-e3pazjdi 295 5 in in IN cord-252725-e3pazjdi 295 6 grape grape NN cord-252725-e3pazjdi 295 7 , , , cord-252725-e3pazjdi 295 8 peanut peanut NN cord-252725-e3pazjdi 295 9 , , , cord-252725-e3pazjdi 295 10 hop hop NN cord-252725-e3pazjdi 295 11 cones cone NNS cord-252725-e3pazjdi 295 12 , , , cord-252725-e3pazjdi 295 13 red red JJ cord-252725-e3pazjdi 295 14 wines wine NNS cord-252725-e3pazjdi 295 15 , , , cord-252725-e3pazjdi 295 16 hop hop NN cord-252725-e3pazjdi 295 17 pellets pellet NNS cord-252725-e3pazjdi 295 18 , , , cord-252725-e3pazjdi 295 19 cocoa cocoa NN cord-252725-e3pazjdi 295 20 - - HYPH cord-252725-e3pazjdi 295 21 containing contain VBG cord-252725-e3pazjdi 295 22 products product NNS cord-252725-e3pazjdi 295 23 , , , cord-252725-e3pazjdi 295 24 chocolate chocolate NN cord-252725-e3pazjdi 295 25 products product NNS cord-252725-e3pazjdi 295 26 and and CC cord-252725-e3pazjdi 295 27 many many JJ cord-252725-e3pazjdi 295 28 daily daily JJ cord-252725-e3pazjdi 295 29 diets diet NNS cord-252725-e3pazjdi 295 30 [ [ -LRB- cord-252725-e3pazjdi 295 31 204 204 CD cord-252725-e3pazjdi 295 32 , , , cord-252725-e3pazjdi 295 33 205 205 CD cord-252725-e3pazjdi 295 34 ] ] -RRB- cord-252725-e3pazjdi 295 35 . . . cord-252725-e3pazjdi 296 1 Unlike unlike IN cord-252725-e3pazjdi 296 2 resveratrol resveratrol NN cord-252725-e3pazjdi 296 3 , , , cord-252725-e3pazjdi 296 4 which which WDT cord-252725-e3pazjdi 296 5 passively passively RB cord-252725-e3pazjdi 296 6 penetrates penetrate VBZ cord-252725-e3pazjdi 296 7 cells cell NNS cord-252725-e3pazjdi 296 8 , , , cord-252725-e3pazjdi 296 9 polydatin polydatin NNP cord-252725-e3pazjdi 296 10 enters enter VBZ cord-252725-e3pazjdi 296 11 cells cell NNS cord-252725-e3pazjdi 296 12 via via IN cord-252725-e3pazjdi 296 13 an an DT cord-252725-e3pazjdi 296 14 active active JJ cord-252725-e3pazjdi 296 15 mechanism mechanism NN cord-252725-e3pazjdi 296 16 using use VBG cord-252725-e3pazjdi 296 17 glucose glucose NN cord-252725-e3pazjdi 296 18 carrier carrier NN cord-252725-e3pazjdi 296 19 and and CC cord-252725-e3pazjdi 296 20 it -PRON- PRP cord-252725-e3pazjdi 296 21 is be VBZ cord-252725-e3pazjdi 296 22 more more RBR cord-252725-e3pazjdi 296 23 resistant resistant JJ cord-252725-e3pazjdi 296 24 to to IN cord-252725-e3pazjdi 296 25 enzymatic enzymatic JJ cord-252725-e3pazjdi 296 26 oxidation oxidation NN cord-252725-e3pazjdi 296 27 than than IN cord-252725-e3pazjdi 296 28 resveratrol resveratrol NN cord-252725-e3pazjdi 296 29 and and CC cord-252725-e3pazjdi 296 30 possesses possess VBZ cord-252725-e3pazjdi 296 31 much much RB cord-252725-e3pazjdi 296 32 better well JJR cord-252725-e3pazjdi 296 33 solubility solubility NN cord-252725-e3pazjdi 296 34 in in IN cord-252725-e3pazjdi 296 35 water water NN cord-252725-e3pazjdi 296 36 [ [ -LRB- cord-252725-e3pazjdi 296 37 206 206 CD cord-252725-e3pazjdi 296 38 ] ] -RRB- cord-252725-e3pazjdi 296 39 . . . cord-252725-e3pazjdi 297 1 Polydatin Polydatin NNP cord-252725-e3pazjdi 297 2 has have VBZ cord-252725-e3pazjdi 297 3 numerous numerous JJ cord-252725-e3pazjdi 297 4 benefits benefit NNS cord-252725-e3pazjdi 297 5 which which WDT cord-252725-e3pazjdi 297 6 is be VBZ cord-252725-e3pazjdi 297 7 widely widely RB cord-252725-e3pazjdi 297 8 reported report VBN cord-252725-e3pazjdi 297 9 including include VBG cord-252725-e3pazjdi 297 10 anti anti JJ cord-252725-e3pazjdi 297 11 - - JJ cord-252725-e3pazjdi 297 12 inflammatory inflammatory JJ cord-252725-e3pazjdi 297 13 effect effect NN cord-252725-e3pazjdi 297 14 in in IN cord-252725-e3pazjdi 297 15 chronic chronic JJ cord-252725-e3pazjdi 297 16 lung lung NN cord-252725-e3pazjdi 297 17 diseases disease NNS cord-252725-e3pazjdi 297 18 , , , cord-252725-e3pazjdi 297 19 anti anti JJ cord-252725-e3pazjdi 297 20 - - JJ cord-252725-e3pazjdi 297 21 oxidative oxidative JJ cord-252725-e3pazjdi 297 22 , , , cord-252725-e3pazjdi 297 23 anti anti JJ cord-252725-e3pazjdi 297 24 - - JJ cord-252725-e3pazjdi 297 25 platelet platelet JJ cord-252725-e3pazjdi 297 26 aggregative aggregative NN cord-252725-e3pazjdi 297 27 , , , cord-252725-e3pazjdi 297 28 anti anti JJ cord-252725-e3pazjdi 297 29 - - JJ cord-252725-e3pazjdi 297 30 fibrosis fibrosis JJ cord-252725-e3pazjdi 297 31 , , , cord-252725-e3pazjdi 297 32 anti anti JJ cord-252725-e3pazjdi 297 33 - - JJ cord-252725-e3pazjdi 297 34 cancer cancer JJ cord-252725-e3pazjdi 297 35 , , , cord-252725-e3pazjdi 297 36 benefits benefit NNS cord-252725-e3pazjdi 297 37 for for IN cord-252725-e3pazjdi 297 38 neurological neurological JJ cord-252725-e3pazjdi 297 39 diseases disease NNS cord-252725-e3pazjdi 297 40 and and CC cord-252725-e3pazjdi 297 41 anxiolytic anxiolytic JJ cord-252725-e3pazjdi 297 42 effects effect NNS cord-252725-e3pazjdi 297 43 [ [ -LRB- cord-252725-e3pazjdi 297 44 207 207 CD cord-252725-e3pazjdi 297 45 , , , cord-252725-e3pazjdi 297 46 208 208 CD cord-252725-e3pazjdi 297 47 ] ] -RRB- cord-252725-e3pazjdi 297 48 . . . cord-252725-e3pazjdi 298 1 A a DT cord-252725-e3pazjdi 298 2 study study NN cord-252725-e3pazjdi 298 3 has have VBZ cord-252725-e3pazjdi 298 4 demonstrated demonstrate VBN cord-252725-e3pazjdi 298 5 that that IN cord-252725-e3pazjdi 298 6 polydatin polydatin NNP cord-252725-e3pazjdi 298 7 improves improve VBZ cord-252725-e3pazjdi 298 8 lipopolysaccharide lipopolysaccharide NN cord-252725-e3pazjdi 298 9 ( ( -LRB- cord-252725-e3pazjdi 298 10 LPS)-induced lps)-induced JJ cord-252725-e3pazjdi 298 11 acute acute JJ cord-252725-e3pazjdi 298 12 respiratory respiratory JJ cord-252725-e3pazjdi 298 13 distress distress NN cord-252725-e3pazjdi 298 14 syndrome syndrome NN cord-252725-e3pazjdi 298 15 ( ( -LRB- cord-252725-e3pazjdi 298 16 ARDS ARDS NNP cord-252725-e3pazjdi 298 17 ) ) -RRB- cord-252725-e3pazjdi 298 18 . . . cord-252725-e3pazjdi 299 1 In in IN cord-252725-e3pazjdi 299 2 addition addition NN cord-252725-e3pazjdi 299 3 , , , cord-252725-e3pazjdi 299 4 polydatin polydatin NNP cord-252725-e3pazjdi 299 5 has have VBZ cord-252725-e3pazjdi 299 6 mediated mediate VBN cord-252725-e3pazjdi 299 7 Parkin Parkin NNP cord-252725-e3pazjdi 299 8 - - HYPH cord-252725-e3pazjdi 299 9 dependent dependent JJ cord-252725-e3pazjdi 299 10 mitophagy mitophagy NN cord-252725-e3pazjdi 299 11 and and CC cord-252725-e3pazjdi 299 12 protects protect VBZ cord-252725-e3pazjdi 299 13 against against IN cord-252725-e3pazjdi 299 14 mitochondria mitochondria NN cord-252725-e3pazjdi 299 15 - - HYPH cord-252725-e3pazjdi 299 16 dependent dependent JJ cord-252725-e3pazjdi 299 17 apoptosis apoptosis NN cord-252725-e3pazjdi 299 18 in in IN cord-252725-e3pazjdi 299 19 ARDS ARDS NNP cord-252725-e3pazjdi 299 20 [ [ -LRB- cord-252725-e3pazjdi 299 21 209 209 CD cord-252725-e3pazjdi 299 22 , , , cord-252725-e3pazjdi 299 23 210 210 CD cord-252725-e3pazjdi 299 24 ] ] -RRB- cord-252725-e3pazjdi 299 25 niae niae NNP cord-252725-e3pazjdi 299 26 ( ( -LRB- cord-252725-e3pazjdi 299 27 MP MP NNP cord-252725-e3pazjdi 299 28 ) ) -RRB- cord-252725-e3pazjdi 299 29 infection infection NN cord-252725-e3pazjdi 299 30 , , , cord-252725-e3pazjdi 299 31 MP MP NNP cord-252725-e3pazjdi 299 32 can can MD cord-252725-e3pazjdi 299 33 infect infect VB cord-252725-e3pazjdi 299 34 both both CC cord-252725-e3pazjdi 299 35 the the DT cord-252725-e3pazjdi 299 36 upper upper JJ cord-252725-e3pazjdi 299 37 and and CC cord-252725-e3pazjdi 299 38 lower low JJR cord-252725-e3pazjdi 299 39 respiratory respiratory JJ cord-252725-e3pazjdi 299 40 tracts tract NNS cord-252725-e3pazjdi 299 41 , , , cord-252725-e3pazjdi 299 42 was be VBD cord-252725-e3pazjdi 299 43 found find VBN cord-252725-e3pazjdi 299 44 to to TO cord-252725-e3pazjdi 299 45 be be VB cord-252725-e3pazjdi 299 46 suppressed suppress VBN cord-252725-e3pazjdi 299 47 by by IN cord-252725-e3pazjdi 299 48 polydatin polydatin NN cord-252725-e3pazjdi 299 49 treatment treatment NN cord-252725-e3pazjdi 299 50 through through IN cord-252725-e3pazjdi 299 51 inhibition inhibition NN cord-252725-e3pazjdi 299 52 of of IN cord-252725-e3pazjdi 299 53 the the DT cord-252725-e3pazjdi 299 54 NACHT NACHT NNP cord-252725-e3pazjdi 299 55 domain- domain- NN cord-252725-e3pazjdi 299 56 , , , cord-252725-e3pazjdi 299 57 leucinerich leucinerich NNP cord-252725-e3pazjdi 299 58 repeat- repeat- NN cord-252725-e3pazjdi 299 59 , , , cord-252725-e3pazjdi 299 60 and and CC cord-252725-e3pazjdi 299 61 pyd pyd NN cord-252725-e3pazjdi 299 62 - - HYPH cord-252725-e3pazjdi 299 63 containing contain VBG cord-252725-e3pazjdi 299 64 protein protein NN cord-252725-e3pazjdi 299 65 3 3 CD cord-252725-e3pazjdi 299 66 inflammasome inflammasome NN cord-252725-e3pazjdi 299 67 ( ( -LRB- cord-252725-e3pazjdi 299 68 NLRP3 NLRP3 NNP cord-252725-e3pazjdi 299 69 ) ) -RRB- cord-252725-e3pazjdi 299 70 and and CC cord-252725-e3pazjdi 299 71 the the DT cord-252725-e3pazjdi 299 72 nuclear nuclear JJ cord-252725-e3pazjdi 299 73 factor factor NN cord-252725-e3pazjdi 299 74 - - HYPH cord-252725-e3pazjdi 299 75 κB κb CD cord-252725-e3pazjdi 299 76 pathway pathway NN cord-252725-e3pazjdi 299 77 after after IN cord-252725-e3pazjdi 299 78 MP MP NNP cord-252725-e3pazjdi 299 79 infection infection NN cord-252725-e3pazjdi 299 80 [ [ -LRB- cord-252725-e3pazjdi 299 81 211 211 CD cord-252725-e3pazjdi 299 82 ] ] -RRB- cord-252725-e3pazjdi 299 83 . . . cord-252725-e3pazjdi 300 1 Actually actually RB cord-252725-e3pazjdi 300 2 , , , cord-252725-e3pazjdi 300 3 several several JJ cord-252725-e3pazjdi 300 4 in in IN cord-252725-e3pazjdi 300 5 vivo vivo NNP cord-252725-e3pazjdi 300 6 studies study NNS cord-252725-e3pazjdi 300 7 have have VBP cord-252725-e3pazjdi 300 8 reported report VBN cord-252725-e3pazjdi 300 9 an an DT cord-252725-e3pazjdi 300 10 important important JJ cord-252725-e3pazjdi 300 11 protective protective JJ cord-252725-e3pazjdi 300 12 role role NN cord-252725-e3pazjdi 300 13 of of IN cord-252725-e3pazjdi 300 14 polydatin polydatin NN cord-252725-e3pazjdi 300 15 treatment treatment NN cord-252725-e3pazjdi 300 16 via via IN cord-252725-e3pazjdi 300 17 different different JJ cord-252725-e3pazjdi 300 18 mechanisms mechanism NNS cord-252725-e3pazjdi 300 19 in in IN cord-252725-e3pazjdi 300 20 ovalbumin ovalbumin NN cord-252725-e3pazjdi 300 21 - - HYPH cord-252725-e3pazjdi 300 22 induced induce VBN cord-252725-e3pazjdi 300 23 bronchial bronchial JJ cord-252725-e3pazjdi 300 24 asthma asthma NN cord-252725-e3pazjdi 300 25 as as RB cord-252725-e3pazjdi 300 26 well well RB cord-252725-e3pazjdi 300 27 as as IN cord-252725-e3pazjdi 300 28 in in IN cord-252725-e3pazjdi 300 29 LPS LPS NNP cord-252725-e3pazjdi 300 30 - - HYPH cord-252725-e3pazjdi 300 31 induced induce VBN cord-252725-e3pazjdi 300 32 acute acute JJ cord-252725-e3pazjdi 300 33 lung lung NN cord-252725-e3pazjdi 300 34 injury injury NN cord-252725-e3pazjdi 300 35 [ [ -LRB- cord-252725-e3pazjdi 300 36 212 212 CD cord-252725-e3pazjdi 300 37 , , , cord-252725-e3pazjdi 300 38 213 213 CD cord-252725-e3pazjdi 300 39 ] ] -RRB- cord-252725-e3pazjdi 300 40 . . . cord-252725-e3pazjdi 301 1 Moreover moreover RB cord-252725-e3pazjdi 301 2 , , , cord-252725-e3pazjdi 301 3 polydatin polydatin NNP cord-252725-e3pazjdi 301 4 protects protect VBZ cord-252725-e3pazjdi 301 5 the the DT cord-252725-e3pazjdi 301 6 respiratory respiratory JJ cord-252725-e3pazjdi 301 7 system system NN cord-252725-e3pazjdi 301 8 from from IN cord-252725-e3pazjdi 301 9 the the DT cord-252725-e3pazjdi 301 10 damage damage NN cord-252725-e3pazjdi 301 11 caused cause VBN cord-252725-e3pazjdi 301 12 by by IN cord-252725-e3pazjdi 301 13 fine fine JJ cord-252725-e3pazjdi 301 14 particulate particulate NN cord-252725-e3pazjdi 301 15 matters matter NNS cord-252725-e3pazjdi 301 16 ( ( -LRB- cord-252725-e3pazjdi 301 17 aerodynamic aerodynamic JJ cord-252725-e3pazjdi 301 18 diameter diameter NN cord-252725-e3pazjdi 301 19 < < XX cord-252725-e3pazjdi 301 20 2.5 2.5 CD cord-252725-e3pazjdi 301 21 μm μm NNS cord-252725-e3pazjdi 301 22 ; ; : cord-252725-e3pazjdi 301 23 PM2.5 PM2.5 NNP cord-252725-e3pazjdi 301 24 ) ) -RRB- cord-252725-e3pazjdi 301 25 during during IN cord-252725-e3pazjdi 301 26 air air NN cord-252725-e3pazjdi 301 27 pollution pollution NN cord-252725-e3pazjdi 301 28 that that WDT cord-252725-e3pazjdi 301 29 may may MD cord-252725-e3pazjdi 301 30 cause cause VB cord-252725-e3pazjdi 301 31 deleterious deleterious JJ cord-252725-e3pazjdi 301 32 effects effect NNS cord-252725-e3pazjdi 301 33 such such JJ cord-252725-e3pazjdi 301 34 as as IN cord-252725-e3pazjdi 301 35 premature premature JJ cord-252725-e3pazjdi 301 36 death death NN cord-252725-e3pazjdi 301 37 among among IN cord-252725-e3pazjdi 301 38 individuals individual NNS cord-252725-e3pazjdi 301 39 due due JJ cord-252725-e3pazjdi 301 40 to to IN cord-252725-e3pazjdi 301 41 lung lung NN cord-252725-e3pazjdi 301 42 disease disease NN cord-252725-e3pazjdi 301 43 , , , cord-252725-e3pazjdi 301 44 lung lung NN cord-252725-e3pazjdi 301 45 dysfunction dysfunction NN cord-252725-e3pazjdi 301 46 and and CC cord-252725-e3pazjdi 301 47 asthma asthma NN cord-252725-e3pazjdi 301 48 exacerbation exacerbation NN cord-252725-e3pazjdi 301 49 , , , cord-252725-e3pazjdi 301 50 mainly mainly RB cord-252725-e3pazjdi 301 51 by by IN cord-252725-e3pazjdi 301 52 the the DT cord-252725-e3pazjdi 301 53 capacity capacity NN cord-252725-e3pazjdi 301 54 of of IN cord-252725-e3pazjdi 301 55 polydatin polydatin NNS cord-252725-e3pazjdi 301 56 to to TO cord-252725-e3pazjdi 301 57 reduce reduce VB cord-252725-e3pazjdi 301 58 the the DT cord-252725-e3pazjdi 301 59 injury injury NN cord-252725-e3pazjdi 301 60 from from IN cord-252725-e3pazjdi 301 61 oxidative oxidative JJ cord-252725-e3pazjdi 301 62 stress stress NN cord-252725-e3pazjdi 301 63 and and CC cord-252725-e3pazjdi 301 64 inflammation inflammation NN cord-252725-e3pazjdi 301 65 in in IN cord-252725-e3pazjdi 301 66 lung lung NN cord-252725-e3pazjdi 301 67 tissues tissue NNS cord-252725-e3pazjdi 301 68 [ [ -LRB- cord-252725-e3pazjdi 301 69 214 214 CD cord-252725-e3pazjdi 301 70 ] ] -RRB- cord-252725-e3pazjdi 301 71 . . . cord-252725-e3pazjdi 302 1 Moreover moreover RB cord-252725-e3pazjdi 302 2 , , , cord-252725-e3pazjdi 302 3 polydatin polydatin NNS cord-252725-e3pazjdi 302 4 can can MD cord-252725-e3pazjdi 302 5 attenuate attenuate VB cord-252725-e3pazjdi 302 6 hypoxic hypoxic JJ cord-252725-e3pazjdi 302 7 pulmonary pulmonary JJ cord-252725-e3pazjdi 302 8 hypertension hypertension NN cord-252725-e3pazjdi 302 9 through through IN cord-252725-e3pazjdi 302 10 Protein Protein NNP cord-252725-e3pazjdi 302 11 Kinase Kinase NNP cord-252725-e3pazjdi 302 12 C C NNP cord-252725-e3pazjdi 302 13 Mechanisms Mechanisms NNPS cord-252725-e3pazjdi 302 14 ( ( -LRB- cord-252725-e3pazjdi 302 15 PKC PKC NNP cord-252725-e3pazjdi 302 16 ) ) -RRB- cord-252725-e3pazjdi 302 17 and and CC cord-252725-e3pazjdi 302 18 it -PRON- PRP cord-252725-e3pazjdi 302 19 might may MD cord-252725-e3pazjdi 302 20 be be VB cord-252725-e3pazjdi 302 21 a a DT cord-252725-e3pazjdi 302 22 promising promising JJ cord-252725-e3pazjdi 302 23 candidate candidate NN cord-252725-e3pazjdi 302 24 for for IN cord-252725-e3pazjdi 302 25 hypoxic hypoxic JJ cord-252725-e3pazjdi 302 26 pulmonary pulmonary JJ cord-252725-e3pazjdi 302 27 treatment treatment NN cord-252725-e3pazjdi 302 28 [ [ -LRB- cord-252725-e3pazjdi 302 29 215 215 CD cord-252725-e3pazjdi 302 30 ] ] -RRB- cord-252725-e3pazjdi 302 31 . . . cord-252725-e3pazjdi 303 1 Polydatin Polydatin NNP cord-252725-e3pazjdi 303 2 was be VBD cord-252725-e3pazjdi 303 3 found find VBN cord-252725-e3pazjdi 303 4 , , , cord-252725-e3pazjdi 303 5 among among IN cord-252725-e3pazjdi 303 6 other other JJ cord-252725-e3pazjdi 303 7 phenolic phenolic JJ cord-252725-e3pazjdi 303 8 compounds compound NNS cord-252725-e3pazjdi 303 9 extracted extract VBN cord-252725-e3pazjdi 303 10 from from IN cord-252725-e3pazjdi 303 11 of of IN cord-252725-e3pazjdi 303 12 Polygonum Polygonum NNP cord-252725-e3pazjdi 303 13 cuspidatum cuspidatum NN cord-252725-e3pazjdi 303 14 , , , cord-252725-e3pazjdi 303 15 to to TO cord-252725-e3pazjdi 303 16 inhibit inhibit VB cord-252725-e3pazjdi 303 17 influenza influenza NN cord-252725-e3pazjdi 303 18 A a DT cord-252725-e3pazjdi 303 19 virus virus NN cord-252725-e3pazjdi 303 20 replication replication NN cord-252725-e3pazjdi 303 21 in in IN cord-252725-e3pazjdi 303 22 A549 a549 JJ cord-252725-e3pazjdi 303 23 cells cell NNS cord-252725-e3pazjdi 303 24 through through IN cord-252725-e3pazjdi 303 25 toll toll NN cord-252725-e3pazjdi 303 26 - - HYPH cord-252725-e3pazjdi 303 27 like like JJ cord-252725-e3pazjdi 303 28 receptor receptor NN cord-252725-e3pazjdi 303 29 9-induced 9-induced CD cord-252725-e3pazjdi 304 1 ( ( -LRB- cord-252725-e3pazjdi 304 2 TLR9 TLR9 NNP cord-252725-e3pazjdi 304 3 ) ) -RRB- cord-252725-e3pazjdi 305 1 interferon interferon NN cord-252725-e3pazjdi 305 2 beta beta NN cord-252725-e3pazjdi 305 3 ( ( -LRB- cord-252725-e3pazjdi 305 4 IFN IFN NNP cord-252725-e3pazjdi 305 5 - - HYPH cord-252725-e3pazjdi 305 6 β β NNP cord-252725-e3pazjdi 305 7 ) ) -RRB- cord-252725-e3pazjdi 305 8 expression expression NN cord-252725-e3pazjdi 305 9 [ [ -LRB- cord-252725-e3pazjdi 305 10 216 216 CD cord-252725-e3pazjdi 305 11 ] ] -RRB- cord-252725-e3pazjdi 305 12 . . . cord-252725-e3pazjdi 306 1 A a DT cord-252725-e3pazjdi 306 2 recent recent JJ cord-252725-e3pazjdi 306 3 docking docking NN cord-252725-e3pazjdi 306 4 study study NN cord-252725-e3pazjdi 306 5 has have VBZ cord-252725-e3pazjdi 306 6 reveal reveal VB cord-252725-e3pazjdi 306 7 that that IN cord-252725-e3pazjdi 306 8 polydatin polydatin NNS cord-252725-e3pazjdi 306 9 , , , cord-252725-e3pazjdi 306 10 is be VBZ cord-252725-e3pazjdi 306 11 a a DT cord-252725-e3pazjdi 306 12 potent potent JJ cord-252725-e3pazjdi 306 13 COVID-19 covid-19 JJ cord-252725-e3pazjdi 306 14 main main JJ cord-252725-e3pazjdi 306 15 protease protease NN cord-252725-e3pazjdi 306 16 ( ( -LRB- cord-252725-e3pazjdi 306 17 Mpro Mpro NNP cord-252725-e3pazjdi 306 18 ) ) -RRB- cord-252725-e3pazjdi 306 19 inhibitor inhibitor NN cord-252725-e3pazjdi 306 20 , , , cord-252725-e3pazjdi 306 21 among among IN cord-252725-e3pazjdi 306 22 other other JJ cord-252725-e3pazjdi 306 23 natural natural JJ cord-252725-e3pazjdi 306 24 phenolic phenolic JJ cord-252725-e3pazjdi 306 25 compounds compound NNS cord-252725-e3pazjdi 306 26 that that WDT cord-252725-e3pazjdi 306 27 have have VBP cord-252725-e3pazjdi 306 28 been be VBN cord-252725-e3pazjdi 306 29 demonstrated demonstrate VBN cord-252725-e3pazjdi 306 30 to to TO cord-252725-e3pazjdi 306 31 have have VB cord-252725-e3pazjdi 306 32 an an DT cord-252725-e3pazjdi 306 33 anti anti JJ cord-252725-e3pazjdi 306 34 - - JJ cord-252725-e3pazjdi 306 35 coronavirus coronavirus JJ cord-252725-e3pazjdi 306 36 activity activity NN cord-252725-e3pazjdi 306 37 [ [ -LRB- cord-252725-e3pazjdi 306 38 217 217 CD cord-252725-e3pazjdi 306 39 ] ] -RRB- cord-252725-e3pazjdi 306 40 . . . cord-252725-e3pazjdi 307 1 Therefore therefore RB cord-252725-e3pazjdi 307 2 , , , cord-252725-e3pazjdi 307 3 regarding regard VBG cord-252725-e3pazjdi 307 4 the the DT cord-252725-e3pazjdi 307 5 enormous enormous JJ cord-252725-e3pazjdi 307 6 protective protective JJ cord-252725-e3pazjdi 307 7 roles role NNS cord-252725-e3pazjdi 307 8 of of IN cord-252725-e3pazjdi 307 9 this this DT cord-252725-e3pazjdi 307 10 natural natural JJ cord-252725-e3pazjdi 307 11 phenolic phenolic JJ cord-252725-e3pazjdi 307 12 compound compound NN cord-252725-e3pazjdi 307 13 on on IN cord-252725-e3pazjdi 307 14 the the DT cord-252725-e3pazjdi 307 15 respiratory respiratory JJ cord-252725-e3pazjdi 307 16 system system NN cord-252725-e3pazjdi 307 17 , , , cord-252725-e3pazjdi 307 18 it -PRON- PRP cord-252725-e3pazjdi 307 19 is be VBZ cord-252725-e3pazjdi 307 20 concluding conclude VBG cord-252725-e3pazjdi 307 21 that that IN cord-252725-e3pazjdi 307 22 polydatin polydatin NNS cord-252725-e3pazjdi 307 23 could could MD cord-252725-e3pazjdi 307 24 be be VB cord-252725-e3pazjdi 307 25 consecrated consecrate VBN cord-252725-e3pazjdi 307 26 as as IN cord-252725-e3pazjdi 307 27 a a DT cord-252725-e3pazjdi 307 28 potential potential JJ cord-252725-e3pazjdi 307 29 molecule molecule NN cord-252725-e3pazjdi 307 30 against against IN cord-252725-e3pazjdi 307 31 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 307 32 infections infection NNS cord-252725-e3pazjdi 307 33 and and CC cord-252725-e3pazjdi 307 34 its -PRON- PRP$ cord-252725-e3pazjdi 307 35 related related JJ cord-252725-e3pazjdi 307 36 symptoms symptom NNS cord-252725-e3pazjdi 307 37 . . . cord-252725-e3pazjdi 307 38 _SP cord-252725-e3pazjdi 308 1 Neobavaisoflavone Neobavaisoflavone NNP cord-252725-e3pazjdi 308 2 ( ( -LRB- cord-252725-e3pazjdi 308 3 7-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl 7-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl CD cord-252725-e3pazjdi 308 4 ) ) -RRB- cord-252725-e3pazjdi 308 5 phenyl phenyl NN cord-252725-e3pazjdi 308 6 ] ] -RRB- cord-252725-e3pazjdi 308 7 chromen-4-one chromen-4-one NNP cord-252725-e3pazjdi 308 8 ) ) -RRB- cord-252725-e3pazjdi 309 1 ( ( -LRB- cord-252725-e3pazjdi 309 2 Fig Fig NNP cord-252725-e3pazjdi 309 3 . . . cord-252725-e3pazjdi 309 4 22 22 CD cord-252725-e3pazjdi 309 5 ) ) -RRB- cord-252725-e3pazjdi 309 6 , , , cord-252725-e3pazjdi 309 7 is be VBZ cord-252725-e3pazjdi 309 8 a a DT cord-252725-e3pazjdi 309 9 flavonoid flavonoid NN cord-252725-e3pazjdi 309 10 compound compound NN cord-252725-e3pazjdi 309 11 isolated isolate VBN cord-252725-e3pazjdi 309 12 mainly mainly RB cord-252725-e3pazjdi 309 13 from from IN cord-252725-e3pazjdi 309 14 Psoraleacorylifolia Psoraleacorylifolia NNP cord-252725-e3pazjdi 309 15 ( ( -LRB- cord-252725-e3pazjdi 309 16 Leguminosae Leguminosae NNP cord-252725-e3pazjdi 309 17 ) ) -RRB- cord-252725-e3pazjdi 309 18 and and CC cord-252725-e3pazjdi 309 19 Erythrina Erythrina NNP cord-252725-e3pazjdi 309 20 species specie NNS cord-252725-e3pazjdi 309 21 . . . cord-252725-e3pazjdi 310 1 Psoralea Psoralea NNP cord-252725-e3pazjdi 310 2 corylifolia corylifolia NN cord-252725-e3pazjdi 310 3 has have VBZ cord-252725-e3pazjdi 310 4 traditionally traditionally RB cord-252725-e3pazjdi 310 5 been be VBN cord-252725-e3pazjdi 310 6 used use VBN cord-252725-e3pazjdi 310 7 in in IN cord-252725-e3pazjdi 310 8 India India NNP cord-252725-e3pazjdi 310 9 , , , cord-252725-e3pazjdi 310 10 China China NNP cord-252725-e3pazjdi 310 11 and and CC cord-252725-e3pazjdi 310 12 Southeastern southeastern JJ cord-252725-e3pazjdi 310 13 Asian asian JJ cord-252725-e3pazjdi 310 14 countries country NNS cord-252725-e3pazjdi 310 15 for for IN cord-252725-e3pazjdi 310 16 the the DT cord-252725-e3pazjdi 310 17 treatment treatment NN cord-252725-e3pazjdi 310 18 of of IN cord-252725-e3pazjdi 310 19 several several JJ cord-252725-e3pazjdi 310 20 diseases disease NNS cord-252725-e3pazjdi 310 21 such such JJ cord-252725-e3pazjdi 310 22 as as IN cord-252725-e3pazjdi 310 23 nephritis nephritis NN cord-252725-e3pazjdi 310 24 , , , cord-252725-e3pazjdi 310 25 asthma asthma NN cord-252725-e3pazjdi 310 26 , , , cord-252725-e3pazjdi 310 27 cough cough NN cord-252725-e3pazjdi 310 28 , , , cord-252725-e3pazjdi 310 29 osteoporosis osteoporosis NN cord-252725-e3pazjdi 310 30 , , , cord-252725-e3pazjdi 310 31 hypertension hypertension NN cord-252725-e3pazjdi 310 32 and and CC cord-252725-e3pazjdi 310 33 cardiovascular cardiovascular JJ cord-252725-e3pazjdi 310 34 diseases disease NNS cord-252725-e3pazjdi 310 35 [ [ -LRB- cord-252725-e3pazjdi 310 36 118 118 CD cord-252725-e3pazjdi 310 37 , , , cord-252725-e3pazjdi 310 38 119 119 CD cord-252725-e3pazjdi 310 39 ] ] -RRB- cord-252725-e3pazjdi 310 40 . . . cord-252725-e3pazjdi 311 1 Psoralea Psoralea NNP cord-252725-e3pazjdi 311 2 corylifolia corylifolia NN cord-252725-e3pazjdi 311 3 contains contain VBZ cord-252725-e3pazjdi 311 4 , , , cord-252725-e3pazjdi 311 5 other other JJ cord-252725-e3pazjdi 311 6 than than IN cord-252725-e3pazjdi 311 7 neobavaisoflavone neobavaisoflavone NNP cord-252725-e3pazjdi 311 8 , , , cord-252725-e3pazjdi 311 9 several several JJ cord-252725-e3pazjdi 311 10 active active JJ cord-252725-e3pazjdi 311 11 compounds compound NNS cord-252725-e3pazjdi 311 12 including include VBG cord-252725-e3pazjdi 311 13 psoralen psoralen NNP cord-252725-e3pazjdi 311 14 , , , cord-252725-e3pazjdi 311 15 isopsoralen isopsoralen NNP cord-252725-e3pazjdi 311 16 , , , cord-252725-e3pazjdi 311 17 psoralidin psoralidin NNP cord-252725-e3pazjdi 311 18 , , , cord-252725-e3pazjdi 311 19 isobavachalcone isobavachalcone NN cord-252725-e3pazjdi 311 20 , , , cord-252725-e3pazjdi 311 21 bavachin bavachin NNP cord-252725-e3pazjdi 311 22 and and CC cord-252725-e3pazjdi 311 23 bakuchiol bakuchiol NNP cord-252725-e3pazjdi 311 24 [ [ -LRB- cord-252725-e3pazjdi 311 25 220 220 CD cord-252725-e3pazjdi 311 26 ] ] -RRB- cord-252725-e3pazjdi 311 27 . . . cord-252725-e3pazjdi 312 1 Moreover moreover RB cord-252725-e3pazjdi 312 2 , , , cord-252725-e3pazjdi 312 3 Psoralea Psoralea NNP cord-252725-e3pazjdi 312 4 corylifolia corylifolia NN cord-252725-e3pazjdi 312 5 seeds seed NNS cord-252725-e3pazjdi 312 6 have have VBP cord-252725-e3pazjdi 312 7 been be VBN cord-252725-e3pazjdi 312 8 reported report VBN cord-252725-e3pazjdi 312 9 to to TO cord-252725-e3pazjdi 312 10 possess possess VB cord-252725-e3pazjdi 312 11 a a DT cord-252725-e3pazjdi 312 12 high high JJ cord-252725-e3pazjdi 312 13 activity activity NN cord-252725-e3pazjdi 312 14 against against IN cord-252725-e3pazjdi 312 15 the the DT cord-252725-e3pazjdi 312 16 SARS SARS NNP cord-252725-e3pazjdi 312 17 - - HYPH cord-252725-e3pazjdi 312 18 CoV CoV NNP cord-252725-e3pazjdi 312 19 papain papain NN cord-252725-e3pazjdi 312 20 - - HYPH cord-252725-e3pazjdi 312 21 like like JJ cord-252725-e3pazjdi 312 22 protease protease NN cord-252725-e3pazjdi 312 23 ( ( -LRB- cord-252725-e3pazjdi 312 24 PLpro PLpro NNP cord-252725-e3pazjdi 312 25 ) ) -RRB- cord-252725-e3pazjdi 312 26 which which WDT cord-252725-e3pazjdi 312 27 is be VBZ cord-252725-e3pazjdi 312 28 the the DT cord-252725-e3pazjdi 312 29 main main JJ cord-252725-e3pazjdi 312 30 enzyme enzyme NN cord-252725-e3pazjdi 312 31 involved involve VBN cord-252725-e3pazjdi 312 32 in in IN cord-252725-e3pazjdi 312 33 SARS SARS NNP cord-252725-e3pazjdi 312 34 virus virus NN cord-252725-e3pazjdi 312 35 replication replication NN cord-252725-e3pazjdi 312 36 [ [ -LRB- cord-252725-e3pazjdi 312 37 221 221 CD cord-252725-e3pazjdi 312 38 ] ] -RRB- cord-252725-e3pazjdi 312 39 . . . cord-252725-e3pazjdi 313 1 In in IN cord-252725-e3pazjdi 313 2 fact fact NN cord-252725-e3pazjdi 313 3 , , , cord-252725-e3pazjdi 313 4 six six CD cord-252725-e3pazjdi 313 5 phenolic phenolic JJ cord-252725-e3pazjdi 313 6 compounds compound NNS cord-252725-e3pazjdi 313 7 with with IN cord-252725-e3pazjdi 313 8 an an DT cord-252725-e3pazjdi 313 9 antiviral antiviral JJ cord-252725-e3pazjdi 313 10 activity activity NN cord-252725-e3pazjdi 313 11 were be VBD cord-252725-e3pazjdi 313 12 isolated isolate VBN cord-252725-e3pazjdi 313 13 from from IN cord-252725-e3pazjdi 313 14 the the DT cord-252725-e3pazjdi 313 15 ethanolic ethanolic NNP cord-252725-e3pazjdi 313 16 extracts extract NNS cord-252725-e3pazjdi 313 17 of of IN cord-252725-e3pazjdi 313 18 Psoralea Psoralea NNP cord-252725-e3pazjdi 313 19 corylifolia corylifolia NN cord-252725-e3pazjdi 313 20 identified identify VBD cord-252725-e3pazjdi 313 21 as as IN cord-252725-e3pazjdi 313 22 , , , cord-252725-e3pazjdi 313 23 bavachinin bavachinin NNP cord-252725-e3pazjdi 313 24 , , , cord-252725-e3pazjdi 313 25 neobavaisoflavone neobavaisoflavone NNP cord-252725-e3pazjdi 313 26 , , , cord-252725-e3pazjdi 313 27 isobavachalcone isobavachalcone NN cord-252725-e3pazjdi 313 28 , , , cord-252725-e3pazjdi 313 29 4′-O 4′-o CD cord-252725-e3pazjdi 313 30 - - HYPH cord-252725-e3pazjdi 313 31 methylbavachalcone methylbavachalcone NN cord-252725-e3pazjdi 313 32 , , , cord-252725-e3pazjdi 313 33 psoralidin psoralidin NNP cord-252725-e3pazjdi 313 34 and and CC cord-252725-e3pazjdi 313 35 corylifol corylifol NN cord-252725-e3pazjdi 313 36 A. A. NNP cord-252725-e3pazjdi 313 37 Isobavachalcone Isobavachalcone NNP cord-252725-e3pazjdi 313 38 and and CC cord-252725-e3pazjdi 313 39 psoralidin psoralidin NNS cord-252725-e3pazjdi 313 40 were be VBD cord-252725-e3pazjdi 313 41 the the DT cord-252725-e3pazjdi 313 42 greatest great JJS cord-252725-e3pazjdi 313 43 antiviral antiviral JJ cord-252725-e3pazjdi 313 44 inhibitors inhibitor NNS cord-252725-e3pazjdi 313 45 of of IN cord-252725-e3pazjdi 313 46 SARS SARS NNP cord-252725-e3pazjdi 313 47 - - HYPH cord-252725-e3pazjdi 313 48 CoV CoV NNP cord-252725-e3pazjdi 313 49 PLpro PLpro NNP cord-252725-e3pazjdi 313 50 [ [ -LRB- cord-252725-e3pazjdi 313 51 222 222 CD cord-252725-e3pazjdi 313 52 ] ] -RRB- cord-252725-e3pazjdi 313 53 . . . cord-252725-e3pazjdi 314 1 Actually actually RB cord-252725-e3pazjdi 314 2 , , , cord-252725-e3pazjdi 314 3 Neobavaisoflavone Neobavaisoflavone NNP cord-252725-e3pazjdi 314 4 has have VBZ cord-252725-e3pazjdi 314 5 numerous numerous JJ cord-252725-e3pazjdi 314 6 biological biological JJ cord-252725-e3pazjdi 314 7 properties property NNS cord-252725-e3pazjdi 314 8 such such JJ cord-252725-e3pazjdi 314 9 as as IN cord-252725-e3pazjdi 314 10 antibacterial antibacterial JJ cord-252725-e3pazjdi 314 11 , , , cord-252725-e3pazjdi 314 12 anti anti JJ cord-252725-e3pazjdi 314 13 - - JJ cord-252725-e3pazjdi 314 14 fungal fungal JJ cord-252725-e3pazjdi 314 15 , , , cord-252725-e3pazjdi 314 16 anti anti JJ cord-252725-e3pazjdi 314 17 - - JJ cord-252725-e3pazjdi 314 18 inflammatory inflammatory JJ cord-252725-e3pazjdi 314 19 , , , cord-252725-e3pazjdi 314 20 antioxidative antioxidative JJ cord-252725-e3pazjdi 314 21 , , , cord-252725-e3pazjdi 314 22 anti anti JJ cord-252725-e3pazjdi 314 23 - - JJ cord-252725-e3pazjdi 314 24 cancer cancer JJ cord-252725-e3pazjdi 314 25 , , , cord-252725-e3pazjdi 314 26 anti anti JJ cord-252725-e3pazjdi 314 27 - - JJ cord-252725-e3pazjdi 314 28 osteoporosis osteoporosis JJ cord-252725-e3pazjdi 314 29 and and CC cord-252725-e3pazjdi 314 30 anti anti JJ cord-252725-e3pazjdi 314 31 - - JJ cord-252725-e3pazjdi 314 32 platelet platelet JJ cord-252725-e3pazjdi 314 33 aggregation aggregation NN cord-252725-e3pazjdi 314 34 [ [ -LRB- cord-252725-e3pazjdi 314 35 223 223 CD cord-252725-e3pazjdi 314 36 , , , cord-252725-e3pazjdi 314 37 224 224 CD cord-252725-e3pazjdi 314 38 ] ] -RRB- cord-252725-e3pazjdi 314 39 . . . cord-252725-e3pazjdi 315 1 In in IN cord-252725-e3pazjdi 315 2 vitro vitro FW cord-252725-e3pazjdi 315 3 , , , cord-252725-e3pazjdi 315 4 neobavaisoflavone neobavaisoflavone NNP cord-252725-e3pazjdi 315 5 significantly significantly RB cord-252725-e3pazjdi 315 6 inhibited inhibit VBD cord-252725-e3pazjdi 315 7 the the DT cord-252725-e3pazjdi 315 8 production production NN cord-252725-e3pazjdi 315 9 of of IN cord-252725-e3pazjdi 315 10 ROS ROS NNP cord-252725-e3pazjdi 315 11 , , , cord-252725-e3pazjdi 315 12 reactive reactive JJ cord-252725-e3pazjdi 315 13 nitrogen nitrogen NN cord-252725-e3pazjdi 315 14 species specie NNS cord-252725-e3pazjdi 315 15 ( ( -LRB- cord-252725-e3pazjdi 315 16 RNS RNS NNP cord-252725-e3pazjdi 315 17 ) ) -RRB- cord-252725-e3pazjdi 315 18 and and CC cord-252725-e3pazjdi 315 19 cytokines cytokine NNS cord-252725-e3pazjdi 315 20 : : : cord-252725-e3pazjdi 315 21 IL-1β il-1β ADD cord-252725-e3pazjdi 315 22 , , , cord-252725-e3pazjdi 315 23 IL-6 IL-6 NNP cord-252725-e3pazjdi 315 24 , , , cord-252725-e3pazjdi 315 25 IL-12p40 IL-12p40 NNP cord-252725-e3pazjdi 315 26 , , , cord-252725-e3pazjdi 315 27 IL-12p70 IL-12p70 NNP cord-252725-e3pazjdi 315 28 , , , cord-252725-e3pazjdi 315 29 and and CC cord-252725-e3pazjdi 315 30 TNF TNF NNP cord-252725-e3pazjdi 315 31 - - HYPH cord-252725-e3pazjdi 315 32 α α NNP cord-252725-e3pazjdi 315 33 in in IN cord-252725-e3pazjdi 315 34 LPS+IFN lps+ifn NN cord-252725-e3pazjdi 315 35 - - HYPH cord-252725-e3pazjdi 315 36 γ γ NN cord-252725-e3pazjdi 315 37 - - : cord-252725-e3pazjdi 315 38 or or CC cord-252725-e3pazjdi 315 39 PMA PMA NNP cord-252725-e3pazjdi 315 40 - - HYPH cord-252725-e3pazjdi 315 41 stimulated stimulate VBN cord-252725-e3pazjdi 315 42 RAW264.7 RAW264.7 NNP cord-252725-e3pazjdi 315 43 macrophages macrophage NNS cord-252725-e3pazjdi 315 44 [ [ -LRB- cord-252725-e3pazjdi 315 45 223 223 CD cord-252725-e3pazjdi 315 46 ] ] -RRB- cord-252725-e3pazjdi 315 47 . . . cord-252725-e3pazjdi 316 1 Actually actually RB cord-252725-e3pazjdi 316 2 , , , cord-252725-e3pazjdi 316 3 Psoralea Psoralea NNP cord-252725-e3pazjdi 316 4 corylifolia corylifolia NNP cord-252725-e3pazjdi 316 5 , , , cord-252725-e3pazjdi 316 6 which which WDT cord-252725-e3pazjdi 316 7 contains contain VBZ cord-252725-e3pazjdi 316 8 neobavaisoflavone neobavaisoflavone NN cord-252725-e3pazjdi 316 9 and and CC cord-252725-e3pazjdi 316 10 other other JJ cord-252725-e3pazjdi 316 11 phenolic phenolic JJ cord-252725-e3pazjdi 316 12 and and CC cord-252725-e3pazjdi 316 13 non non JJ cord-252725-e3pazjdi 316 14 - - JJ cord-252725-e3pazjdi 316 15 phenolic phenolic JJ cord-252725-e3pazjdi 316 16 compounds compound NNS cord-252725-e3pazjdi 316 17 maybe maybe RB cord-252725-e3pazjdi 316 18 used use VBN cord-252725-e3pazjdi 316 19 as as IN cord-252725-e3pazjdi 316 20 a a DT cord-252725-e3pazjdi 316 21 target target NN cord-252725-e3pazjdi 316 22 for for IN cord-252725-e3pazjdi 316 23 a a DT cord-252725-e3pazjdi 316 24 more more RBR cord-252725-e3pazjdi 316 25 focused focused JJ cord-252725-e3pazjdi 316 26 research research NN cord-252725-e3pazjdi 316 27 against against IN cord-252725-e3pazjdi 316 28 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 316 29 and and CC cord-252725-e3pazjdi 316 30 related relate VBN cord-252725-e3pazjdi 316 31 symptoms symptom NNS cord-252725-e3pazjdi 316 32 , , , cord-252725-e3pazjdi 316 33 since since IN cord-252725-e3pazjdi 316 34 its -PRON- PRP$ cord-252725-e3pazjdi 316 35 extract extract NN cord-252725-e3pazjdi 316 36 was be VBD cord-252725-e3pazjdi 316 37 found find VBN cord-252725-e3pazjdi 316 38 to to TO cord-252725-e3pazjdi 316 39 inhibit inhibit VB cord-252725-e3pazjdi 316 40 a a DT cord-252725-e3pazjdi 316 41 human human JJ cord-252725-e3pazjdi 316 42 coronavirus coronavirus NN cord-252725-e3pazjdi 316 43 strain strain NN cord-252725-e3pazjdi 316 44 [ [ -LRB- cord-252725-e3pazjdi 316 45 224 224 CD cord-252725-e3pazjdi 316 46 ] ] -RRB- cord-252725-e3pazjdi 316 47 . . . cord-252725-e3pazjdi 317 1 Natural natural JJ cord-252725-e3pazjdi 317 2 compounds compound NNS cord-252725-e3pazjdi 317 3 such such JJ cord-252725-e3pazjdi 317 4 as as IN cord-252725-e3pazjdi 317 5 polyphenols polyphenol NNS cord-252725-e3pazjdi 317 6 with with IN cord-252725-e3pazjdi 317 7 their -PRON- PRP$ cord-252725-e3pazjdi 317 8 countless countless JJ cord-252725-e3pazjdi 317 9 properties property NNS cord-252725-e3pazjdi 317 10 seem seem VBP cord-252725-e3pazjdi 317 11 to to TO cord-252725-e3pazjdi 317 12 be be VB cord-252725-e3pazjdi 317 13 a a DT cord-252725-e3pazjdi 317 14 simple simple JJ cord-252725-e3pazjdi 317 15 , , , cord-252725-e3pazjdi 317 16 safe safe JJ cord-252725-e3pazjdi 317 17 and and CC cord-252725-e3pazjdi 317 18 economical economical JJ cord-252725-e3pazjdi 317 19 approach approach NN cord-252725-e3pazjdi 317 20 due due IN cord-252725-e3pazjdi 317 21 to to IN cord-252725-e3pazjdi 317 22 their -PRON- PRP$ cord-252725-e3pazjdi 317 23 numerous numerous JJ cord-252725-e3pazjdi 317 24 beneficial beneficial JJ cord-252725-e3pazjdi 317 25 effects effect NNS cord-252725-e3pazjdi 317 26 on on IN cord-252725-e3pazjdi 317 27 human human JJ cord-252725-e3pazjdi 317 28 chronic chronic JJ cord-252725-e3pazjdi 317 29 diseases disease NNS cord-252725-e3pazjdi 317 30 as as RB cord-252725-e3pazjdi 317 31 well well RB cord-252725-e3pazjdi 317 32 as as IN cord-252725-e3pazjdi 317 33 on on IN cord-252725-e3pazjdi 317 34 several several JJ cord-252725-e3pazjdi 317 35 bacterial bacterial JJ cord-252725-e3pazjdi 317 36 and and CC cord-252725-e3pazjdi 317 37 viral viral JJ cord-252725-e3pazjdi 317 38 infectious infectious JJ cord-252725-e3pazjdi 317 39 diseases disease NNS cord-252725-e3pazjdi 317 40 through through IN cord-252725-e3pazjdi 317 41 their -PRON- PRP$ cord-252725-e3pazjdi 317 42 favorable favorable JJ cord-252725-e3pazjdi 317 43 effects effect NNS cord-252725-e3pazjdi 317 44 on on IN cord-252725-e3pazjdi 317 45 several several JJ cord-252725-e3pazjdi 317 46 cellular cellular JJ cord-252725-e3pazjdi 317 47 and and CC cord-252725-e3pazjdi 317 48 molecular molecular JJ cord-252725-e3pazjdi 317 49 pathways pathway NNS cord-252725-e3pazjdi 317 50 , , , cord-252725-e3pazjdi 317 51 which which WDT cord-252725-e3pazjdi 317 52 leads lead VBZ cord-252725-e3pazjdi 317 53 to to IN cord-252725-e3pazjdi 317 54 an an DT cord-252725-e3pazjdi 317 55 enhanced enhance VBN cord-252725-e3pazjdi 317 56 body body NN cord-252725-e3pazjdi 317 57 immunity immunity NN cord-252725-e3pazjdi 317 58 against against IN cord-252725-e3pazjdi 317 59 infection infection NN cord-252725-e3pazjdi 317 60 . . . cord-252725-e3pazjdi 318 1 This this DT cord-252725-e3pazjdi 318 2 review review NN cord-252725-e3pazjdi 318 3 summarized summarize VBD cord-252725-e3pazjdi 318 4 the the DT cord-252725-e3pazjdi 318 5 most most RBS cord-252725-e3pazjdi 318 6 studied study VBN cord-252725-e3pazjdi 318 7 polyphenolic polyphenolic JJ cord-252725-e3pazjdi 318 8 compounds compound NNS cord-252725-e3pazjdi 318 9 , , , cord-252725-e3pazjdi 318 10 their -PRON- PRP$ cord-252725-e3pazjdi 318 11 main main JJ cord-252725-e3pazjdi 318 12 natural natural JJ cord-252725-e3pazjdi 318 13 origin origin NN cord-252725-e3pazjdi 318 14 , , , cord-252725-e3pazjdi 318 15 their -PRON- PRP$ cord-252725-e3pazjdi 318 16 general general JJ cord-252725-e3pazjdi 318 17 role role NN cord-252725-e3pazjdi 318 18 in in IN cord-252725-e3pazjdi 318 19 human human JJ cord-252725-e3pazjdi 318 20 health health NN cord-252725-e3pazjdi 318 21 focusing focus VBG cord-252725-e3pazjdi 318 22 particularly particularly RB cord-252725-e3pazjdi 318 23 on on IN cord-252725-e3pazjdi 318 24 their -PRON- PRP$ cord-252725-e3pazjdi 318 25 role role NN cord-252725-e3pazjdi 318 26 as as IN cord-252725-e3pazjdi 318 27 an an DT cord-252725-e3pazjdi 318 28 antiviral antiviral JJ cord-252725-e3pazjdi 318 29 agent agent NN cord-252725-e3pazjdi 318 30 against against IN cord-252725-e3pazjdi 318 31 respiratory respiratory JJ cord-252725-e3pazjdi 318 32 tract tract NN cord-252725-e3pazjdi 318 33 infections infection NNS cord-252725-e3pazjdi 318 34 and and CC cord-252725-e3pazjdi 318 35 their -PRON- PRP$ cord-252725-e3pazjdi 318 36 perceptive perceptive JJ cord-252725-e3pazjdi 318 37 role role NN cord-252725-e3pazjdi 318 38 in in IN cord-252725-e3pazjdi 318 39 the the DT cord-252725-e3pazjdi 318 40 fight fight NN cord-252725-e3pazjdi 318 41 against against IN cord-252725-e3pazjdi 318 42 COVID-19 COVID-19 NNP cord-252725-e3pazjdi 318 43 , , , cord-252725-e3pazjdi 318 44 related related JJ cord-252725-e3pazjdi 318 45 symptoms symptom NNS cord-252725-e3pazjdi 318 46 and and CC cord-252725-e3pazjdi 318 47 other other JJ cord-252725-e3pazjdi 318 48 emergence emergence NN cord-252725-e3pazjdi 318 49 diseases disease NNS cord-252725-e3pazjdi 318 50 . . . cord-252725-e3pazjdi 319 1 Better well JJR cord-252725-e3pazjdi 319 2 design design NN cord-252725-e3pazjdi 319 3 of of IN cord-252725-e3pazjdi 319 4 experimental experimental JJ cord-252725-e3pazjdi 319 5 as as RB cord-252725-e3pazjdi 319 6 well well RB cord-252725-e3pazjdi 319 7 as as IN cord-252725-e3pazjdi 319 8 human human JJ cord-252725-e3pazjdi 319 9 clinical clinical JJ cord-252725-e3pazjdi 319 10 studies study NNS cord-252725-e3pazjdi 319 11 addressing address VBG cord-252725-e3pazjdi 319 12 dosage dosage NN cord-252725-e3pazjdi 319 13 and and CC cord-252725-e3pazjdi 319 14 combinations combination NNS cord-252725-e3pazjdi 319 15 of of IN cord-252725-e3pazjdi 319 16 polyphenol polyphenol NN cord-252725-e3pazjdi 319 17 compounds compound NNS cord-252725-e3pazjdi 319 18 , , , cord-252725-e3pazjdi 319 19 their -PRON- PRP$ cord-252725-e3pazjdi 319 20 derivatives derivative NNS cord-252725-e3pazjdi 319 21 and and CC cord-252725-e3pazjdi 319 22 other other JJ cord-252725-e3pazjdi 319 23 synthetized synthetize VBN cord-252725-e3pazjdi 319 24 molecules molecule NNS cord-252725-e3pazjdi 319 25 are be VBP cord-252725-e3pazjdi 319 26 required require VBN cord-252725-e3pazjdi 319 27 to to TO cord-252725-e3pazjdi 319 28 substantiate substantiate VB cord-252725-e3pazjdi 319 29 the the DT cord-252725-e3pazjdi 319 30 benefits benefit NNS cord-252725-e3pazjdi 319 31 of of IN cord-252725-e3pazjdi 319 32 such such JJ cord-252725-e3pazjdi 319 33 wonderful wonderful JJ cord-252725-e3pazjdi 319 34 natural natural JJ cord-252725-e3pazjdi 319 35 compounds compound NNS cord-252725-e3pazjdi 319 36 for for IN cord-252725-e3pazjdi 319 37 therapeutic therapeutic JJ cord-252725-e3pazjdi 319 38 and and CC cord-252725-e3pazjdi 319 39 preventive preventive JJ cord-252725-e3pazjdi 319 40 purposes purpose NNS cord-252725-e3pazjdi 319 41 against against IN cord-252725-e3pazjdi 319 42 infections infection NNS cord-252725-e3pazjdi 319 43 . . . cord-252725-e3pazjdi 320 1 Open open VB cord-252725-e3pazjdi 320 2 Access Access NNP cord-252725-e3pazjdi 321 1 This this DT cord-252725-e3pazjdi 321 2 article article NN cord-252725-e3pazjdi 321 3 is be VBZ cord-252725-e3pazjdi 321 4 licensed license VBN cord-252725-e3pazjdi 321 5 under under IN cord-252725-e3pazjdi 321 6 a a DT cord-252725-e3pazjdi 321 7 Creative Creative NNP cord-252725-e3pazjdi 321 8 Commons Commons NNP cord-252725-e3pazjdi 321 9 Attribution Attribution NNP cord-252725-e3pazjdi 321 10 4.0 4.0 CD cord-252725-e3pazjdi 321 11 International International NNP cord-252725-e3pazjdi 321 12 License License NNP cord-252725-e3pazjdi 321 13 , , , cord-252725-e3pazjdi 321 14 which which WDT cord-252725-e3pazjdi 321 15 permits permit VBZ cord-252725-e3pazjdi 321 16 use use NN cord-252725-e3pazjdi 321 17 , , , cord-252725-e3pazjdi 321 18 sharing sharing NN cord-252725-e3pazjdi 321 19 , , , cord-252725-e3pazjdi 321 20 adaptation adaptation NN cord-252725-e3pazjdi 321 21 , , , cord-252725-e3pazjdi 321 22 distribution distribution NN cord-252725-e3pazjdi 321 23 and and CC cord-252725-e3pazjdi 321 24 reproduction reproduction NN cord-252725-e3pazjdi 321 25 in in IN cord-252725-e3pazjdi 321 26 any any DT cord-252725-e3pazjdi 321 27 medium medium NN cord-252725-e3pazjdi 321 28 or or CC cord-252725-e3pazjdi 321 29 format format NN cord-252725-e3pazjdi 321 30 , , , cord-252725-e3pazjdi 321 31 as as RB cord-252725-e3pazjdi 321 32 long long RB cord-252725-e3pazjdi 321 33 as as IN cord-252725-e3pazjdi 321 34 you -PRON- PRP cord-252725-e3pazjdi 321 35 give give VBP cord-252725-e3pazjdi 321 36 appropriate appropriate JJ cord-252725-e3pazjdi 321 37 credit credit NN cord-252725-e3pazjdi 321 38 to to IN cord-252725-e3pazjdi 321 39 the the DT cord-252725-e3pazjdi 321 40 original original JJ cord-252725-e3pazjdi 321 41 author(s author(s NNP cord-252725-e3pazjdi 321 42 ) ) -RRB- cord-252725-e3pazjdi 321 43 and and CC cord-252725-e3pazjdi 321 44 the the DT cord-252725-e3pazjdi 321 45 source source NN cord-252725-e3pazjdi 321 46 , , , cord-252725-e3pazjdi 321 47 provide provide VB cord-252725-e3pazjdi 321 48 a a DT cord-252725-e3pazjdi 321 49 link link NN cord-252725-e3pazjdi 321 50 to to IN cord-252725-e3pazjdi 321 51 the the DT cord-252725-e3pazjdi 321 52 Creative Creative NNP cord-252725-e3pazjdi 321 53 Commons Commons NNP cord-252725-e3pazjdi 321 54 licence licence NN cord-252725-e3pazjdi 321 55 , , , cord-252725-e3pazjdi 321 56 and and CC cord-252725-e3pazjdi 321 57 indicate indicate VBP cord-252725-e3pazjdi 321 58 if if IN cord-252725-e3pazjdi 321 59 changes change NNS cord-252725-e3pazjdi 321 60 were be VBD cord-252725-e3pazjdi 321 61 made make VBN cord-252725-e3pazjdi 321 62 . . . cord-252725-e3pazjdi 322 1 The the DT cord-252725-e3pazjdi 322 2 images image NNS cord-252725-e3pazjdi 322 3 or or CC cord-252725-e3pazjdi 322 4 other other JJ cord-252725-e3pazjdi 322 5 third third JJ cord-252725-e3pazjdi 322 6 party party NN cord-252725-e3pazjdi 322 7 material material NN cord-252725-e3pazjdi 322 8 in in IN cord-252725-e3pazjdi 322 9 this this DT cord-252725-e3pazjdi 322 10 article article NN cord-252725-e3pazjdi 322 11 are be VBP cord-252725-e3pazjdi 322 12 included include VBN cord-252725-e3pazjdi 322 13 in in IN cord-252725-e3pazjdi 322 14 the the DT cord-252725-e3pazjdi 322 15 article article NN cord-252725-e3pazjdi 322 16 's 's POS cord-252725-e3pazjdi 322 17 Creative Creative NNP cord-252725-e3pazjdi 322 18 Commons Commons NNP cord-252725-e3pazjdi 322 19 licence licence NN cord-252725-e3pazjdi 322 20 , , , cord-252725-e3pazjdi 322 21 unless unless IN cord-252725-e3pazjdi 322 22 indicated indicate VBN cord-252725-e3pazjdi 322 23 otherwise otherwise RB cord-252725-e3pazjdi 322 24 in in IN cord-252725-e3pazjdi 322 25 a a DT cord-252725-e3pazjdi 322 26 credit credit NN cord-252725-e3pazjdi 322 27 line line NN cord-252725-e3pazjdi 322 28 to to IN cord-252725-e3pazjdi 322 29 the the DT cord-252725-e3pazjdi 322 30 material material NN cord-252725-e3pazjdi 322 31 . . . cord-252725-e3pazjdi 323 1 If if IN cord-252725-e3pazjdi 323 2 material material NN cord-252725-e3pazjdi 323 3 is be VBZ cord-252725-e3pazjdi 323 4 not not RB cord-252725-e3pazjdi 323 5 included include VBN cord-252725-e3pazjdi 323 6 in in IN cord-252725-e3pazjdi 323 7 the the DT cord-252725-e3pazjdi 323 8 article article NN cord-252725-e3pazjdi 323 9 's 's POS cord-252725-e3pazjdi 323 10 Creative Creative NNP cord-252725-e3pazjdi 323 11 Commons Commons NNP cord-252725-e3pazjdi 323 12 licence licence NN cord-252725-e3pazjdi 323 13 and and CC cord-252725-e3pazjdi 323 14 your -PRON- PRP$ cord-252725-e3pazjdi 323 15 intended intend VBN cord-252725-e3pazjdi 323 16 use use NN cord-252725-e3pazjdi 323 17 is be VBZ cord-252725-e3pazjdi 323 18 not not RB cord-252725-e3pazjdi 323 19 permitted permit VBN cord-252725-e3pazjdi 323 20 by by IN cord-252725-e3pazjdi 323 21 statutory statutory JJ cord-252725-e3pazjdi 323 22 regulation regulation NN cord-252725-e3pazjdi 323 23 or or CC cord-252725-e3pazjdi 323 24 exceeds exceed VBZ cord-252725-e3pazjdi 323 25 the the DT cord-252725-e3pazjdi 323 26 permitted permit VBN cord-252725-e3pazjdi 323 27 use use NN cord-252725-e3pazjdi 323 28 , , , cord-252725-e3pazjdi 323 29 you -PRON- PRP cord-252725-e3pazjdi 323 30 will will MD cord-252725-e3pazjdi 323 31 need need VB cord-252725-e3pazjdi 323 32 to to TO cord-252725-e3pazjdi 323 33 obtain obtain VB cord-252725-e3pazjdi 323 34 permission permission NN cord-252725-e3pazjdi 323 35 directly directly RB cord-252725-e3pazjdi 323 36 from from IN cord-252725-e3pazjdi 323 37 the the DT cord-252725-e3pazjdi 323 38 copyright copyright NN cord-252725-e3pazjdi 323 39 holder holder NN cord-252725-e3pazjdi 323 40 . . . cord-252725-e3pazjdi 324 1 To to TO cord-252725-e3pazjdi 324 2 view view VB cord-252725-e3pazjdi 324 3 a a DT cord-252725-e3pazjdi 324 4 copy copy NN cord-252725-e3pazjdi 324 5 of of IN cord-252725-e3pazjdi 324 6 this this DT cord-252725-e3pazjdi 324 7 licence licence NN cord-252725-e3pazjdi 324 8 , , , cord-252725-e3pazjdi 324 9 visit visit VB cord-252725-e3pazjdi 324 10 http://creat http://creat NNP cord-252725-e3pazjdi 324 11 iveco iveco NNP cord-252725-e3pazjdi 324 12 mmons mmons NNP cord-252725-e3pazjdi 324 13 .org .org . cord-252725-e3pazjdi 325 1 / / NFP cord-252725-e3pazjdi 326 1 licen licen NNP cord-252725-e3pazjdi 326 2 ses ses NNP cord-252725-e3pazjdi 326 3 / / SYM cord-252725-e3pazjdi 326 4 by/4.0/. by/4.0/. NNP cord-252725-e3pazjdi 326 5 Structure Structure NNP cord-252725-e3pazjdi 326 6 of of IN cord-252725-e3pazjdi 326 7 neobavaisoflavone neobavaisoflavone NNP cord-252725-e3pazjdi 326 8 Effective effective JJ cord-252725-e3pazjdi 326 9 inhibition inhibition NN cord-252725-e3pazjdi 326 10 of of IN cord-252725-e3pazjdi 326 11 MERS MERS NNP cord-252725-e3pazjdi 326 12 - - HYPH cord-252725-e3pazjdi 326 13 CoV cov NN cord-252725-e3pazjdi 326 14 infection infection NN cord-252725-e3pazjdi 326 15 by by IN cord-252725-e3pazjdi 326 16 resveratrol resveratrol NN cord-252725-e3pazjdi 326 17 Studies Studies NNPS cord-252725-e3pazjdi 326 18 in in IN cord-252725-e3pazjdi 326 19 Natural Natural NNP cord-252725-e3pazjdi 326 20 Products Products NNPS cord-252725-e3pazjdi 326 21 Chemistry Chemistry NNP cord-252725-e3pazjdi 327 1 Chapter chapter NN cord-252725-e3pazjdi 327 2 34 34 CD