id sid tid token lemma pos cord-262511-96xp1v0r 1 1 key key NN cord-262511-96xp1v0r 1 2 : : : cord-262511-96xp1v0r 2 1 cord-262511 cord-262511 NNP cord-262511-96xp1v0r 2 2 - - HYPH cord-262511-96xp1v0r 2 3 96xp1v0r 96xp1v0r CD cord-262511-96xp1v0r 2 4 authors author NNS cord-262511-96xp1v0r 2 5 : : : cord-262511-96xp1v0r 2 6 Khabar Khabar NNP cord-262511-96xp1v0r 2 7 , , , cord-262511-96xp1v0r 2 8 Khalid Khalid NNP cord-262511-96xp1v0r 2 9 S. S. NNP cord-262511-96xp1v0r 2 10 A. a. NN cord-262511-96xp1v0r 2 11 title title NN cord-262511-96xp1v0r 2 12 : : : cord-262511-96xp1v0r 2 13 Rapid rapid JJ cord-262511-96xp1v0r 2 14 transit transit NN cord-262511-96xp1v0r 2 15 in in IN cord-262511-96xp1v0r 2 16 the the DT cord-262511-96xp1v0r 2 17 immune immune JJ cord-262511-96xp1v0r 2 18 cells cell NNS cord-262511-96xp1v0r 2 19 : : : cord-262511-96xp1v0r 2 20 the the DT cord-262511-96xp1v0r 2 21 role role NN cord-262511-96xp1v0r 2 22 of of IN cord-262511-96xp1v0r 2 23 mRNA mRNA NNP cord-262511-96xp1v0r 2 24 turnover turnover NN cord-262511-96xp1v0r 2 25 regulation regulation NN cord-262511-96xp1v0r 2 26 date date NN cord-262511-96xp1v0r 2 27 : : : cord-262511-96xp1v0r 2 28 2007 2007 CD cord-262511-96xp1v0r 2 29 - - HYPH cord-262511-96xp1v0r 2 30 03 03 CD cord-262511-96xp1v0r 2 31 - - SYM cord-262511-96xp1v0r 2 32 30 30 CD cord-262511-96xp1v0r 2 33 journal journal NN cord-262511-96xp1v0r 2 34 : : : cord-262511-96xp1v0r 2 35 J J NNP cord-262511-96xp1v0r 2 36 Leukoc Leukoc NNP cord-262511-96xp1v0r 2 37 Biol Biol NNP cord-262511-96xp1v0r 3 1 DOI DOI NNP cord-262511-96xp1v0r 3 2 : : : cord-262511-96xp1v0r 4 1 10.1189 10.1189 LS cord-262511-96xp1v0r 4 2 / / SYM cord-262511-96xp1v0r 4 3 jlb.0207109 jlb.0207109 NNP cord-262511-96xp1v0r 4 4 sha sha NNP cord-262511-96xp1v0r 4 5 : : : cord-262511-96xp1v0r 4 6 1a53cc3deef275deabaf9774fc3fdf5631954934 1a53cc3deef275deabaf9774fc3fdf5631954934 CD cord-262511-96xp1v0r 4 7 doc_id doc_id CD cord-262511-96xp1v0r 4 8 : : : cord-262511-96xp1v0r 4 9 262511 262511 CD cord-262511-96xp1v0r 4 10 cord_uid cord_uid NNS cord-262511-96xp1v0r 4 11 : : : cord-262511-96xp1v0r 5 1 96xp1v0r 96xp1v0r CD cord-262511-96xp1v0r 6 1 There there EX cord-262511-96xp1v0r 6 2 have have VBP cord-262511-96xp1v0r 6 3 been be VBN cord-262511-96xp1v0r 6 4 recent recent JJ cord-262511-96xp1v0r 6 5 , , , cord-262511-96xp1v0r 6 6 significant significant JJ cord-262511-96xp1v0r 6 7 advances advance NNS cord-262511-96xp1v0r 6 8 about about IN cord-262511-96xp1v0r 6 9 the the DT cord-262511-96xp1v0r 6 10 role role NN cord-262511-96xp1v0r 6 11 of of IN cord-262511-96xp1v0r 6 12 mRNA mRNA NNP cord-262511-96xp1v0r 6 13 turnover turnover NN cord-262511-96xp1v0r 6 14 in in IN cord-262511-96xp1v0r 6 15 controlling control VBG cord-262511-96xp1v0r 6 16 gene gene NN cord-262511-96xp1v0r 6 17 expression expression NN cord-262511-96xp1v0r 6 18 in in IN cord-262511-96xp1v0r 6 19 immune immune JJ cord-262511-96xp1v0r 6 20 cells cell NNS cord-262511-96xp1v0r 6 21 . . . cord-262511-96xp1v0r 7 1 Post‐transcriptional post‐transcriptional JJ cord-262511-96xp1v0r 7 2 regulation regulation NN cord-262511-96xp1v0r 7 3 of of IN cord-262511-96xp1v0r 7 4 gene gene NN cord-262511-96xp1v0r 7 5 expression expression NN cord-262511-96xp1v0r 7 6 contributes contribute VBZ cord-262511-96xp1v0r 7 7 to to IN cord-262511-96xp1v0r 7 8 the the DT cord-262511-96xp1v0r 7 9 characteristics characteristic NNS cord-262511-96xp1v0r 7 10 of of IN cord-262511-96xp1v0r 7 11 many many JJ cord-262511-96xp1v0r 7 12 of of IN cord-262511-96xp1v0r 7 13 the the DT cord-262511-96xp1v0r 7 14 processes process NNS cord-262511-96xp1v0r 7 15 underlying underlie VBG cord-262511-96xp1v0r 7 16 the the DT cord-262511-96xp1v0r 7 17 immune immune JJ cord-262511-96xp1v0r 7 18 response response NN cord-262511-96xp1v0r 7 19 by by IN cord-262511-96xp1v0r 7 20 ensuring ensure VBG cord-262511-96xp1v0r 7 21 early early RB cord-262511-96xp1v0r 7 22 , , , cord-262511-96xp1v0r 7 23 rapid rapid JJ cord-262511-96xp1v0r 7 24 , , , cord-262511-96xp1v0r 7 25 and and CC cord-262511-96xp1v0r 7 26 transient transient JJ cord-262511-96xp1v0r 7 27 action action NN cord-262511-96xp1v0r 7 28 . . . cord-262511-96xp1v0r 8 1 The the DT cord-262511-96xp1v0r 8 2 emphasis emphasis NN cord-262511-96xp1v0r 8 3 of of IN cord-262511-96xp1v0r 8 4 this this DT cord-262511-96xp1v0r 8 5 review review NN cord-262511-96xp1v0r 8 6 is be VBZ cord-262511-96xp1v0r 8 7 on on IN cord-262511-96xp1v0r 8 8 current current JJ cord-262511-96xp1v0r 8 9 work work NN cord-262511-96xp1v0r 8 10 that that WDT cord-262511-96xp1v0r 8 11 deals deal VBZ cord-262511-96xp1v0r 8 12 with with IN cord-262511-96xp1v0r 8 13 the the DT cord-262511-96xp1v0r 8 14 regulation regulation NN cord-262511-96xp1v0r 8 15 of of IN cord-262511-96xp1v0r 8 16 mRNA mrna NN cord-262511-96xp1v0r 8 17 decay decay NN cord-262511-96xp1v0r 8 18 during during IN cord-262511-96xp1v0r 8 19 innate innate JJ cord-262511-96xp1v0r 8 20 immunity immunity NN cord-262511-96xp1v0r 8 21 against against IN cord-262511-96xp1v0r 8 22 microbes microbe NNS cord-262511-96xp1v0r 8 23 and and CC cord-262511-96xp1v0r 8 24 T T NNP cord-262511-96xp1v0r 8 25 cell cell NN cord-262511-96xp1v0r 8 26 activation activation NN cord-262511-96xp1v0r 8 27 as as IN cord-262511-96xp1v0r 8 28 a a DT cord-262511-96xp1v0r 8 29 model model NN cord-262511-96xp1v0r 8 30 of of IN cord-262511-96xp1v0r 8 31 the the DT cord-262511-96xp1v0r 8 32 adaptive adaptive JJ cord-262511-96xp1v0r 8 33 response response NN cord-262511-96xp1v0r 8 34 . . . cord-262511-96xp1v0r 9 1 In in IN cord-262511-96xp1v0r 9 2 large large JJ cord-262511-96xp1v0r 9 3 cities city NNS cord-262511-96xp1v0r 9 4 , , , cord-262511-96xp1v0r 9 5 " " `` cord-262511-96xp1v0r 9 6 rapid rapid JJ cord-262511-96xp1v0r 9 7 transit transit NN cord-262511-96xp1v0r 9 8 " " '' cord-262511-96xp1v0r 9 9 is be VBZ cord-262511-96xp1v0r 9 10 a a DT cord-262511-96xp1v0r 9 11 term term NN cord-262511-96xp1v0r 9 12 that that WDT cord-262511-96xp1v0r 9 13 refers refer VBZ cord-262511-96xp1v0r 9 14 to to IN cord-262511-96xp1v0r 9 15 the the DT cord-262511-96xp1v0r 9 16 efficient efficient JJ cord-262511-96xp1v0r 9 17 movement movement NN cord-262511-96xp1v0r 9 18 of of IN cord-262511-96xp1v0r 9 19 people people NNS cord-262511-96xp1v0r 9 20 allowing allow VBG cord-262511-96xp1v0r 9 21 rapid rapid JJ cord-262511-96xp1v0r 9 22 entry entry NN cord-262511-96xp1v0r 9 23 and and CC cord-262511-96xp1v0r 9 24 exit exit NN cord-262511-96xp1v0r 9 25 from from IN cord-262511-96xp1v0r 9 26 a a DT cord-262511-96xp1v0r 9 27 transportation transportation NN cord-262511-96xp1v0r 9 28 system system NN cord-262511-96xp1v0r 9 29 . . . cord-262511-96xp1v0r 10 1 A a DT cord-262511-96xp1v0r 10 2 rapid rapid JJ cord-262511-96xp1v0r 10 3 transit transit NN cord-262511-96xp1v0r 10 4 scheme scheme NN cord-262511-96xp1v0r 10 5 also also RB cord-262511-96xp1v0r 10 6 occurs occur VBZ cord-262511-96xp1v0r 10 7 in in IN cord-262511-96xp1v0r 10 8 the the DT cord-262511-96xp1v0r 10 9 immune immune JJ cord-262511-96xp1v0r 10 10 system system NN cord-262511-96xp1v0r 10 11 to to TO cord-262511-96xp1v0r 10 12 allow allow VB cord-262511-96xp1v0r 10 13 immediate immediate JJ cord-262511-96xp1v0r 10 14 activation activation NN cord-262511-96xp1v0r 10 15 of of IN cord-262511-96xp1v0r 10 16 the the DT cord-262511-96xp1v0r 10 17 immune immune JJ cord-262511-96xp1v0r 10 18 cells cell NNS cord-262511-96xp1v0r 10 19 toward toward IN cord-262511-96xp1v0r 10 20 microbes microbe NNS cord-262511-96xp1v0r 10 21 , , , cord-262511-96xp1v0r 10 22 transient transient JJ cord-262511-96xp1v0r 10 23 mode mode NN cord-262511-96xp1v0r 10 24 of of IN cord-262511-96xp1v0r 10 25 action action NN cord-262511-96xp1v0r 10 26 , , , cord-262511-96xp1v0r 10 27 and and CC cord-262511-96xp1v0r 10 28 swift swift JJ cord-262511-96xp1v0r 10 29 recovery recovery NN cord-262511-96xp1v0r 10 30 . . . cord-262511-96xp1v0r 11 1 Post post JJ cord-262511-96xp1v0r 11 2 - - JJ cord-262511-96xp1v0r 11 3 transcriptional transcriptional JJ cord-262511-96xp1v0r 11 4 regulation regulation NN cord-262511-96xp1v0r 11 5 contributes contribute VBZ cord-262511-96xp1v0r 11 6 significantly significantly RB cord-262511-96xp1v0r 11 7 to to IN cord-262511-96xp1v0r 11 8 this this DT cord-262511-96xp1v0r 11 9 rapid rapid JJ cord-262511-96xp1v0r 11 10 transit transit NN cord-262511-96xp1v0r 11 11 by by IN cord-262511-96xp1v0r 11 12 several several JJ cord-262511-96xp1v0r 11 13 mechanisms mechanism NNS cord-262511-96xp1v0r 11 14 , , , cord-262511-96xp1v0r 11 15 including include VBG cord-262511-96xp1v0r 11 16 mRNA mRNA NNP cord-262511-96xp1v0r 11 17 stability stability NN cord-262511-96xp1v0r 11 18 modulation modulation NN cord-262511-96xp1v0r 11 19 and and CC cord-262511-96xp1v0r 11 20 translational translational JJ cord-262511-96xp1v0r 11 21 control control NN cord-262511-96xp1v0r 11 22 ; ; : cord-262511-96xp1v0r 11 23 collectively collectively RB cord-262511-96xp1v0r 11 24 , , , cord-262511-96xp1v0r 11 25 they -PRON- PRP cord-262511-96xp1v0r 11 26 aim aim VBP cord-262511-96xp1v0r 11 27 to to TO cord-262511-96xp1v0r 11 28 control control VB cord-262511-96xp1v0r 11 29 the the DT cord-262511-96xp1v0r 11 30 expression expression NN cord-262511-96xp1v0r 11 31 of of IN cord-262511-96xp1v0r 11 32 key key JJ cord-262511-96xp1v0r 11 33 gene gene NN cord-262511-96xp1v0r 11 34 products product NNS cord-262511-96xp1v0r 11 35 involved involve VBN cord-262511-96xp1v0r 11 36 in in IN cord-262511-96xp1v0r 11 37 the the DT cord-262511-96xp1v0r 11 38 immune immune JJ cord-262511-96xp1v0r 11 39 response response NN cord-262511-96xp1v0r 11 40 . . . cord-262511-96xp1v0r 12 1 Sequence sequence NN cord-262511-96xp1v0r 12 2 elements element NNS cord-262511-96xp1v0r 12 3 , , , cord-262511-96xp1v0r 12 4 mainly mainly RB cord-262511-96xp1v0r 12 5 in in IN cord-262511-96xp1v0r 12 6 the the DT cord-262511-96xp1v0r 12 7 3Ј 3ј CD cord-262511-96xp1v0r 12 8 untranslated untranslated JJ cord-262511-96xp1v0r 12 9 region region NN cord-262511-96xp1v0r 12 10 ( ( -LRB- cord-262511-96xp1v0r 12 11 3ЈUTR 3ЈUTR NNP cord-262511-96xp1v0r 12 12 ) ) -RRB- cord-262511-96xp1v0r 12 13 , , , cord-262511-96xp1v0r 12 14 and and CC cord-262511-96xp1v0r 12 15 modulation modulation NN cord-262511-96xp1v0r 12 16 by by IN cord-262511-96xp1v0r 12 17 RNA rna NN cord-262511-96xp1v0r 12 18 - - HYPH cord-262511-96xp1v0r 12 19 binding bind VBG cord-262511-96xp1v0r 12 20 proteins protein NNS cord-262511-96xp1v0r 12 21 can can MD cord-262511-96xp1v0r 12 22 affect affect VB cord-262511-96xp1v0r 12 23 mRNA mrna NN cord-262511-96xp1v0r 12 24 stability stability NN cord-262511-96xp1v0r 12 25 and and CC cord-262511-96xp1v0r 12 26 protein protein NN cord-262511-96xp1v0r 12 27 translation translation NN cord-262511-96xp1v0r 12 28 . . . cord-262511-96xp1v0r 13 1 Many many JJ cord-262511-96xp1v0r 13 2 of of IN cord-262511-96xp1v0r 13 3 the the DT cord-262511-96xp1v0r 13 4 gene gene NN cord-262511-96xp1v0r 13 5 products product NNS cord-262511-96xp1v0r 13 6 involved involve VBN cord-262511-96xp1v0r 13 7 in in IN cord-262511-96xp1v0r 13 8 the the DT cord-262511-96xp1v0r 13 9 immune immune JJ cord-262511-96xp1v0r 13 10 system system NN cord-262511-96xp1v0r 13 11 , , , cord-262511-96xp1v0r 13 12 such such JJ cord-262511-96xp1v0r 13 13 as as IN cord-262511-96xp1v0r 13 14 cytokines cytokine NNS cord-262511-96xp1v0r 13 15 , , , cord-262511-96xp1v0r 13 16 harbor harbor NN cord-262511-96xp1v0r 13 17 destabilization destabilization NN cord-262511-96xp1v0r 13 18 sequence sequence NN cord-262511-96xp1v0r 13 19 elements element NNS cord-262511-96xp1v0r 13 20 in in IN cord-262511-96xp1v0r 13 21 the the DT cord-262511-96xp1v0r 13 22 mRNA mrna NN cord-262511-96xp1v0r 13 23 , , , cord-262511-96xp1v0r 13 24 mostly mostly RB cord-262511-96xp1v0r 13 25 adenylate adenylate NN cord-262511-96xp1v0r 13 26 - - HYPH cord-262511-96xp1v0r 13 27 uridylate uridylate JJ cord-262511-96xp1v0r 13 28 ( ( -LRB- cord-262511-96xp1v0r 13 29 AU)-rich au)-rich CD cord-262511-96xp1v0r 13 30 elements element NNS cord-262511-96xp1v0r 13 31 ( ( -LRB- cord-262511-96xp1v0r 13 32 AREs AREs NNP cord-262511-96xp1v0r 13 33 ) ) -RRB- cord-262511-96xp1v0r 13 34 , , , cord-262511-96xp1v0r 13 35 which which WDT cord-262511-96xp1v0r 13 36 comprise comprise VBP cord-262511-96xp1v0r 13 37 a a DT cord-262511-96xp1v0r 13 38 heterogeneous heterogeneous JJ cord-262511-96xp1v0r 13 39 group group NN cord-262511-96xp1v0r 13 40 of of IN cord-262511-96xp1v0r 13 41 sequence sequence NN cord-262511-96xp1v0r 13 42 classes class NNS cord-262511-96xp1v0r 13 43 that that WDT cord-262511-96xp1v0r 13 44 can can MD cord-262511-96xp1v0r 13 45 affect affect VB cord-262511-96xp1v0r 13 46 protein protein NN cord-262511-96xp1v0r 13 47 interactions interaction NNS cord-262511-96xp1v0r 13 48 with with IN cord-262511-96xp1v0r 13 49 the the DT cord-262511-96xp1v0r 13 50 mRNAs mrna NNS cord-262511-96xp1v0r 13 51 and and CC cord-262511-96xp1v0r 13 52 therefore therefore RB cord-262511-96xp1v0r 13 53 influence influence VBP cord-262511-96xp1v0r 13 54 the the DT cord-262511-96xp1v0r 13 55 mRNA mRNA NNP cord-262511-96xp1v0r 13 56 decay decay NN cord-262511-96xp1v0r 13 57 characteristics characteristic NNS cord-262511-96xp1v0r 13 58 [ [ -LRB- cord-262511-96xp1v0r 13 59 1 1 CD cord-262511-96xp1v0r 13 60 , , , cord-262511-96xp1v0r 13 61 2 2 CD cord-262511-96xp1v0r 13 62 ] ] -RRB- cord-262511-96xp1v0r 13 63 . . . cord-262511-96xp1v0r 14 1 Large large JJ cord-262511-96xp1v0r 14 2 - - HYPH cord-262511-96xp1v0r 14 3 scale scale NN cord-262511-96xp1v0r 14 4 studies study NNS cord-262511-96xp1v0r 14 5 involving involve VBG cord-262511-96xp1v0r 14 6 profiling profiling NN cord-262511-96xp1v0r 14 7 of of IN cord-262511-96xp1v0r 14 8 mRNAs mRNAs NNPS cord-262511-96xp1v0r 14 9 that that WDT cord-262511-96xp1v0r 14 10 are be VBP cord-262511-96xp1v0r 14 11 bound bind VBN cord-262511-96xp1v0r 14 12 to to IN cord-262511-96xp1v0r 14 13 RNA rna NN cord-262511-96xp1v0r 14 14 - - HYPH cord-262511-96xp1v0r 14 15 binding bind VBG cord-262511-96xp1v0r 14 16 proteins protein NNS cord-262511-96xp1v0r 14 17 indicate indicate VBP cord-262511-96xp1v0r 14 18 that that IN cord-262511-96xp1v0r 14 19 many many JJ cord-262511-96xp1v0r 14 20 of of IN cord-262511-96xp1v0r 14 21 these these DT cord-262511-96xp1v0r 14 22 genes gene NNS cord-262511-96xp1v0r 14 23 are be VBP cord-262511-96xp1v0r 14 24 involved involve VBN cord-262511-96xp1v0r 14 25 in in IN cord-262511-96xp1v0r 14 26 the the DT cord-262511-96xp1v0r 14 27 early early JJ cord-262511-96xp1v0r 14 28 response response NN cord-262511-96xp1v0r 14 29 to to IN cord-262511-96xp1v0r 14 30 stimuli stimulus NNS cord-262511-96xp1v0r 14 31 , , , cord-262511-96xp1v0r 14 32 host host NN cord-262511-96xp1v0r 14 33 defense defense NN cord-262511-96xp1v0r 14 34 , , , cord-262511-96xp1v0r 14 35 and and CC cord-262511-96xp1v0r 14 36 regulation regulation NN cord-262511-96xp1v0r 14 37 of of IN cord-262511-96xp1v0r 14 38 RNA RNA NNP cord-262511-96xp1v0r 14 39 metabolism metabolism NN cord-262511-96xp1v0r 14 40 and and CC cord-262511-96xp1v0r 14 41 translation translation NN cord-262511-96xp1v0r 14 42 [ [ -LRB- cord-262511-96xp1v0r 14 43 3 3 CD cord-262511-96xp1v0r 14 44 ] ] -RRB- cord-262511-96xp1v0r 14 45 [ [ -LRB- cord-262511-96xp1v0r 14 46 4 4 CD cord-262511-96xp1v0r 14 47 ] ] -RRB- cord-262511-96xp1v0r 14 48 [ [ -LRB- cord-262511-96xp1v0r 14 49 5 5 CD cord-262511-96xp1v0r 14 50 ] ] -RRB- cord-262511-96xp1v0r 14 51 . . . cord-262511-96xp1v0r 15 1 The the DT cord-262511-96xp1v0r 15 2 stabilization stabilization NN cord-262511-96xp1v0r 15 3 of of IN cord-262511-96xp1v0r 15 4 cytokine cytokine NN cord-262511-96xp1v0r 15 5 mRNA mrna NN cord-262511-96xp1v0r 15 6 and and CC cord-262511-96xp1v0r 15 7 other other JJ cord-262511-96xp1v0r 15 8 immune immune JJ cord-262511-96xp1v0r 15 9 response response NN cord-262511-96xp1v0r 15 10 gene gene NN cord-262511-96xp1v0r 15 11 products product NNS cord-262511-96xp1v0r 15 12 can can MD cord-262511-96xp1v0r 15 13 occur occur VB cord-262511-96xp1v0r 15 14 by by IN cord-262511-96xp1v0r 15 15 the the DT cord-262511-96xp1v0r 15 16 activity activity NN cord-262511-96xp1v0r 15 17 of of IN cord-262511-96xp1v0r 15 18 mRNA mRNA NNP cord-262511-96xp1v0r 15 19 stabilization stabilization NN cord-262511-96xp1v0r 15 20 - - HYPH cord-262511-96xp1v0r 15 21 promoting promote VBG cord-262511-96xp1v0r 15 22 proteins protein NNS cord-262511-96xp1v0r 15 23 such such JJ cord-262511-96xp1v0r 15 24 as as IN cord-262511-96xp1v0r 15 25 human human JJ cord-262511-96xp1v0r 15 26 antigen antigen NN cord-262511-96xp1v0r 15 27 ( ( -LRB- cord-262511-96xp1v0r 15 28 HuR HuR NNP cord-262511-96xp1v0r 15 29 ) ) -RRB- cord-262511-96xp1v0r 15 30 protein protein NN cord-262511-96xp1v0r 15 31 or or CC cord-262511-96xp1v0r 15 32 by by IN cord-262511-96xp1v0r 15 33 inactivation inactivation NN cord-262511-96xp1v0r 15 34 of of IN cord-262511-96xp1v0r 15 35 RNA RNA NNP cord-262511-96xp1v0r 15 36 decay decay NN cord-262511-96xp1v0r 15 37 - - HYPH cord-262511-96xp1v0r 15 38 promoting promote VBG cord-262511-96xp1v0r 15 39 proteins protein NNS cord-262511-96xp1v0r 15 40 such such JJ cord-262511-96xp1v0r 15 41 as as IN cord-262511-96xp1v0r 15 42 the the DT cord-262511-96xp1v0r 15 43 zinc zinc NN cord-262511-96xp1v0r 15 44 finger finger NN cord-262511-96xp1v0r 15 45 protein protein NN cord-262511-96xp1v0r 15 46 , , , cord-262511-96xp1v0r 15 47 tristetraprolin tristetraprolin NNP cord-262511-96xp1v0r 15 48 ( ( -LRB- cord-262511-96xp1v0r 15 49 TTP TTP NNP cord-262511-96xp1v0r 15 50 ) ) -RRB- cord-262511-96xp1v0r 15 51 . . . cord-262511-96xp1v0r 16 1 HuR HuR NNP cord-262511-96xp1v0r 16 2 is be VBZ cord-262511-96xp1v0r 16 3 one one CD cord-262511-96xp1v0r 16 4 of of IN cord-262511-96xp1v0r 16 5 the the DT cord-262511-96xp1v0r 16 6 most most RBS cord-262511-96xp1v0r 16 7 characterized characterize VBN cord-262511-96xp1v0r 16 8 RNA rna NN cord-262511-96xp1v0r 16 9 - - HYPH cord-262511-96xp1v0r 16 10 binding bind VBG cord-262511-96xp1v0r 16 11 proteins protein NNS cord-262511-96xp1v0r 16 12 ; ; : cord-262511-96xp1v0r 16 13 it -PRON- PRP cord-262511-96xp1v0r 16 14 is be VBZ cord-262511-96xp1v0r 16 15 a a DT cord-262511-96xp1v0r 16 16 mammalian mammalian JJ cord-262511-96xp1v0r 16 17 homologue homologue NN cord-262511-96xp1v0r 16 18 of of IN cord-262511-96xp1v0r 16 19 embryonic embryonic JJ cord-262511-96xp1v0r 16 20 , , , cord-262511-96xp1v0r 16 21 lethal lethal JJ cord-262511-96xp1v0r 16 22 , , , cord-262511-96xp1v0r 16 23 abnormal abnormal JJ cord-262511-96xp1v0r 16 24 vision vision NN cord-262511-96xp1v0r 16 25 proteins protein NNS cord-262511-96xp1v0r 16 26 , , , cord-262511-96xp1v0r 16 27 which which WDT cord-262511-96xp1v0r 16 28 was be VBD cord-262511-96xp1v0r 16 29 first first RB cord-262511-96xp1v0r 16 30 described describe VBN cord-262511-96xp1v0r 16 31 in in IN cord-262511-96xp1v0r 16 32 Drosophila Drosophila NNP cord-262511-96xp1v0r 16 33 . . . cord-262511-96xp1v0r 17 1 It -PRON- PRP cord-262511-96xp1v0r 17 2 is be VBZ cord-262511-96xp1v0r 17 3 implicated implicate VBN cord-262511-96xp1v0r 17 4 in in IN cord-262511-96xp1v0r 17 5 the the DT cord-262511-96xp1v0r 17 6 stabilization stabilization NN cord-262511-96xp1v0r 17 7 of of IN cord-262511-96xp1v0r 17 8 many many JJ cord-262511-96xp1v0r 17 9 AU AU NNP cord-262511-96xp1v0r 17 10 - - HYPH cord-262511-96xp1v0r 17 11 rich rich JJ cord-262511-96xp1v0r 17 12 mRNAs mRNAs NNPS cord-262511-96xp1v0r 17 13 including include VBG cord-262511-96xp1v0r 17 14 those those DT cord-262511-96xp1v0r 17 15 that that WDT cord-262511-96xp1v0r 17 16 participate participate VBP cord-262511-96xp1v0r 17 17 in in IN cord-262511-96xp1v0r 17 18 immunity immunity NN cord-262511-96xp1v0r 17 19 and and CC cord-262511-96xp1v0r 17 20 inflammation inflammation NN cord-262511-96xp1v0r 17 21 such such JJ cord-262511-96xp1v0r 17 22 as as IN cord-262511-96xp1v0r 17 23 TNF- TNF- NNP cord-262511-96xp1v0r 17 24 ␣ ␣ NNP cord-262511-96xp1v0r 17 25 , , , cord-262511-96xp1v0r 17 26 IL-3 IL-3 NNP cord-262511-96xp1v0r 17 27 , , , cord-262511-96xp1v0r 17 28 IL-8 IL-8 NNP cord-262511-96xp1v0r 17 29 , , , cord-262511-96xp1v0r 17 30 and and CC cord-262511-96xp1v0r 17 31 the the DT cord-262511-96xp1v0r 17 32 urokinase urokinase NNP cord-262511-96xp1v0r 17 33 activator activator NN cord-262511-96xp1v0r 17 34 , , , cord-262511-96xp1v0r 17 35 urokinase urokinase NN cord-262511-96xp1v0r 17 36 - - HYPH cord-262511-96xp1v0r 17 37 type type NN cord-262511-96xp1v0r 17 38 plasminogen plasminogen NN cord-262511-96xp1v0r 17 39 activator activator NN cord-262511-96xp1v0r 17 40 [ [ -LRB- cord-262511-96xp1v0r 17 41 6 6 CD cord-262511-96xp1v0r 17 42 -8 -8 NNPS cord-262511-96xp1v0r 17 43 ] ] -RRB- cord-262511-96xp1v0r 17 44 . . . cord-262511-96xp1v0r 18 1 Among among IN cord-262511-96xp1v0r 18 2 RNA rna NN cord-262511-96xp1v0r 18 3 - - HYPH cord-262511-96xp1v0r 18 4 binding bind VBG cord-262511-96xp1v0r 18 5 proteins protein NNS cord-262511-96xp1v0r 18 6 that that WDT cord-262511-96xp1v0r 18 7 promote promote VBP cord-262511-96xp1v0r 18 8 mRNA mrna NN cord-262511-96xp1v0r 18 9 decay decay NN cord-262511-96xp1v0r 18 10 is be VBZ cord-262511-96xp1v0r 18 11 TTP TTP NNP cord-262511-96xp1v0r 18 12 . . . cord-262511-96xp1v0r 19 1 It -PRON- PRP cord-262511-96xp1v0r 19 2 is be VBZ cord-262511-96xp1v0r 19 3 an an DT cord-262511-96xp1v0r 19 4 endotoxin endotoxin NN cord-262511-96xp1v0r 19 5 - - HYPH cord-262511-96xp1v0r 19 6 inducible inducible JJ cord-262511-96xp1v0r 19 7 , , , cord-262511-96xp1v0r 19 8 early early JJ cord-262511-96xp1v0r 19 9 response response NN cord-262511-96xp1v0r 19 10 gene gene NN cord-262511-96xp1v0r 19 11 product product NN cord-262511-96xp1v0r 19 12 , , , cord-262511-96xp1v0r 19 13 which which WDT cord-262511-96xp1v0r 19 14 destabilizes destabilize VBZ cord-262511-96xp1v0r 19 15 several several JJ cord-262511-96xp1v0r 19 16 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 19 17 cytokine cytokine NN cord-262511-96xp1v0r 19 18 mRNAs mrnas XX cord-262511-96xp1v0r 19 19 including include VBG cord-262511-96xp1v0r 19 20 TNF- TNF- NNP cord-262511-96xp1v0r 19 21 ␣ ␣ NNP cord-262511-96xp1v0r 19 22 , , , cord-262511-96xp1v0r 19 23 GM GM NNP cord-262511-96xp1v0r 19 24 - - HYPH cord-262511-96xp1v0r 19 25 CSF CSF NNP cord-262511-96xp1v0r 19 26 , , , cord-262511-96xp1v0r 19 27 and and CC cord-262511-96xp1v0r 19 28 IL-2 il-2 NN cord-262511-96xp1v0r 19 29 by by IN cord-262511-96xp1v0r 19 30 binding bind VBG cord-262511-96xp1v0r 19 31 to to IN cord-262511-96xp1v0r 19 32 a a DT cord-262511-96xp1v0r 19 33 specific specific JJ cord-262511-96xp1v0r 19 34 class class NN cord-262511-96xp1v0r 19 35 of of IN cord-262511-96xp1v0r 19 36 AREs are NNS cord-262511-96xp1v0r 19 37 in in IN cord-262511-96xp1v0r 19 38 the the DT cord-262511-96xp1v0r 19 39 3ЈUTR 3јutr CD cord-262511-96xp1v0r 19 40 . . . cord-262511-96xp1v0r 20 1 In in IN cord-262511-96xp1v0r 20 2 addition addition NN cord-262511-96xp1v0r 20 3 to to IN cord-262511-96xp1v0r 20 4 TTP TTP NNP cord-262511-96xp1v0r 20 5 , , , cord-262511-96xp1v0r 20 6 K k NN cord-262511-96xp1v0r 20 7 - - HYPH cord-262511-96xp1v0r 20 8 homology homology NN cord-262511-96xp1v0r 20 9 splicing splicing NN cord-262511-96xp1v0r 20 10 - - HYPH cord-262511-96xp1v0r 20 11 regulatory regulatory JJ cord-262511-96xp1v0r 20 12 protein protein NN cord-262511-96xp1v0r 20 13 ( ( -LRB- cord-262511-96xp1v0r 20 14 KSRP KSRP NNP cord-262511-96xp1v0r 20 15 [ [ -LRB- cord-262511-96xp1v0r 20 16 9 9 CD cord-262511-96xp1v0r 20 17 ] ] -RRB- cord-262511-96xp1v0r 20 18 ) ) -RRB- cord-262511-96xp1v0r 20 19 , , , cord-262511-96xp1v0r 20 20 butyrate butyrate NN cord-262511-96xp1v0r 20 21 response response NN cord-262511-96xp1v0r 20 22 factor factor NN cord-262511-96xp1v0r 20 23 ( ( -LRB- cord-262511-96xp1v0r 20 24 BRF1 BRF1 NNP cord-262511-96xp1v0r 20 25 [ [ -LRB- cord-262511-96xp1v0r 20 26 10 10 CD cord-262511-96xp1v0r 20 27 ] ] -RRB- cord-262511-96xp1v0r 20 28 ) ) -RRB- cord-262511-96xp1v0r 20 29 , , , cord-262511-96xp1v0r 20 30 and and CC cord-262511-96xp1v0r 20 31 certain certain JJ cord-262511-96xp1v0r 20 32 gene gene NN cord-262511-96xp1v0r 20 33 products product NNS cord-262511-96xp1v0r 20 34 of of IN cord-262511-96xp1v0r 20 35 the the DT cord-262511-96xp1v0r 20 36 ARE ARE NNP cord-262511-96xp1v0r 20 37 RNA rna NN cord-262511-96xp1v0r 20 38 - - HYPH cord-262511-96xp1v0r 20 39 binding bind VBG cord-262511-96xp1v0r 20 40 protein protein NN cord-262511-96xp1v0r 20 41 1 1 CD cord-262511-96xp1v0r 20 42 [ [ -LRB- cord-262511-96xp1v0r 20 43 ARE/ ARE/ NNP cord-262511-96xp1v0r 20 44 poly(U)-binding poly(u)-binding NN cord-262511-96xp1v0r 20 45 / / SYM cord-262511-96xp1v0r 20 46 degradation degradation NN cord-262511-96xp1v0r 20 47 factor factor NN cord-262511-96xp1v0r 20 48 1 1 CD cord-262511-96xp1v0r 20 49 ( ( -LRB- cord-262511-96xp1v0r 20 50 AUF1 AUF1 NNP cord-262511-96xp1v0r 20 51 ) ) -RRB- cord-262511-96xp1v0r 21 1 ] ] -RRB- cord-262511-96xp1v0r 21 2 family family NN cord-262511-96xp1v0r 21 3 [ [ -LRB- cord-262511-96xp1v0r 21 4 2 2 CD cord-262511-96xp1v0r 21 5 ] ] -RRB- cord-262511-96xp1v0r 21 6 are be VBP cord-262511-96xp1v0r 21 7 considered consider VBN cord-262511-96xp1v0r 21 8 negative negative JJ cord-262511-96xp1v0r 21 9 - - HYPH cord-262511-96xp1v0r 21 10 feedback feedback NN cord-262511-96xp1v0r 21 11 mediators mediator NNS cord-262511-96xp1v0r 21 12 . . . cord-262511-96xp1v0r 22 1 TTP TTP NNP cord-262511-96xp1v0r 22 2 and and CC cord-262511-96xp1v0r 22 3 several several JJ cord-262511-96xp1v0r 22 4 other other JJ cord-262511-96xp1v0r 22 5 RNA RNA NNP cord-262511-96xp1v0r 22 6 - - HYPH cord-262511-96xp1v0r 22 7 binding bind VBG cord-262511-96xp1v0r 22 8 proteins protein NNS cord-262511-96xp1v0r 22 9 appear appear VBP cord-262511-96xp1v0r 22 10 to to TO cord-262511-96xp1v0r 22 11 function function VB cord-262511-96xp1v0r 22 12 by by IN cord-262511-96xp1v0r 22 13 targeting target VBG cord-262511-96xp1v0r 22 14 AU AU NNP cord-262511-96xp1v0r 22 15 - - HYPH cord-262511-96xp1v0r 22 16 rich rich JJ cord-262511-96xp1v0r 22 17 mRNA mrna NN cord-262511-96xp1v0r 22 18 to to IN cord-262511-96xp1v0r 22 19 the the DT cord-262511-96xp1v0r 22 20 exosome exosome NN cord-262511-96xp1v0r 22 21 , , , cord-262511-96xp1v0r 22 22 a a DT cord-262511-96xp1v0r 22 23 multiprotein multiprotein NN cord-262511-96xp1v0r 22 24 complex complex NN cord-262511-96xp1v0r 22 25 with with IN cord-262511-96xp1v0r 22 26 3Ј-5Ј 3ј-5ј CD cord-262511-96xp1v0r 22 27 exoRNase exornase NN cord-262511-96xp1v0r 22 28 activity activity NN cord-262511-96xp1v0r 22 29 representing represent VBG cord-262511-96xp1v0r 22 30 a a DT cord-262511-96xp1v0r 22 31 major major JJ cord-262511-96xp1v0r 22 32 degradation degradation NN cord-262511-96xp1v0r 22 33 machine machine NN cord-262511-96xp1v0r 22 34 in in IN cord-262511-96xp1v0r 22 35 eukaryotes eukaryote NNS cord-262511-96xp1v0r 22 36 [ [ -LRB- cord-262511-96xp1v0r 22 37 11 11 CD cord-262511-96xp1v0r 22 38 ] ] -RRB- cord-262511-96xp1v0r 22 39 . . . cord-262511-96xp1v0r 23 1 ARE are VBP cord-262511-96xp1v0r 23 2 - - HYPH cord-262511-96xp1v0r 23 3 binding bind VBG cord-262511-96xp1v0r 23 4 proteins protein NNS cord-262511-96xp1v0r 23 5 can can MD cord-262511-96xp1v0r 23 6 also also RB cord-262511-96xp1v0r 23 7 function function VB cord-262511-96xp1v0r 23 8 by by IN cord-262511-96xp1v0r 23 9 recruitment recruitment NN cord-262511-96xp1v0r 23 10 of of IN cord-262511-96xp1v0r 23 11 degradation degradation NN cord-262511-96xp1v0r 23 12 factors factor NNS cord-262511-96xp1v0r 23 13 other other JJ cord-262511-96xp1v0r 23 14 than than IN cord-262511-96xp1v0r 23 15 the the DT cord-262511-96xp1v0r 23 16 exosome exosome NN cord-262511-96xp1v0r 23 17 [ [ -LRB- cord-262511-96xp1v0r 23 18 12 12 CD cord-262511-96xp1v0r 23 19 , , , cord-262511-96xp1v0r 23 20 13 13 CD cord-262511-96xp1v0r 23 21 ] ] -RRB- cord-262511-96xp1v0r 23 22 . . . cord-262511-96xp1v0r 24 1 An an DT cord-262511-96xp1v0r 24 2 alternative alternative JJ cord-262511-96xp1v0r 24 3 pathway pathway NN cord-262511-96xp1v0r 24 4 of of IN cord-262511-96xp1v0r 24 5 5Ј-3Ј 5ј-3ј CD cord-262511-96xp1v0r 24 6 decay decay NN cord-262511-96xp1v0r 24 7 can can MD cord-262511-96xp1v0r 24 8 also also RB cord-262511-96xp1v0r 24 9 occur occur VB cord-262511-96xp1v0r 24 10 during during IN cord-262511-96xp1v0r 24 11 degradation degradation NN cord-262511-96xp1v0r 24 12 of of IN cord-262511-96xp1v0r 24 13 AU AU NNP cord-262511-96xp1v0r 24 14 - - HYPH cord-262511-96xp1v0r 24 15 rich rich JJ cord-262511-96xp1v0r 24 16 mRNAs mRNAs NNPS cord-262511-96xp1v0r 24 17 in in IN cord-262511-96xp1v0r 24 18 cytoplasmic cytoplasmic JJ cord-262511-96xp1v0r 24 19 RNA RNA NNP cord-262511-96xp1v0r 24 20 foci foci NN cord-262511-96xp1v0r 24 21 - - HYPH cord-262511-96xp1v0r 24 22 processing process VBG cord-262511-96xp1v0r 24 23 bodies body NNS cord-262511-96xp1v0r 24 24 [ [ -LRB- cord-262511-96xp1v0r 24 25 14 14 CD cord-262511-96xp1v0r 24 26 ] ] -RRB- cord-262511-96xp1v0r 24 27 . . . cord-262511-96xp1v0r 25 1 After after IN cord-262511-96xp1v0r 25 2 a a DT cord-262511-96xp1v0r 25 3 brief brief JJ cord-262511-96xp1v0r 25 4 introduction introduction NN cord-262511-96xp1v0r 25 5 about about IN cord-262511-96xp1v0r 25 6 the the DT cord-262511-96xp1v0r 25 7 major major JJ cord-262511-96xp1v0r 25 8 signaling signal VBG cord-262511-96xp1v0r 25 9 pathway pathway NN cord-262511-96xp1v0r 25 10 regulating regulate VBG cord-262511-96xp1v0r 25 11 mRNA mRNA NNP cord-262511-96xp1v0r 25 12 turnover turnover NN cord-262511-96xp1v0r 25 13 , , , cord-262511-96xp1v0r 25 14 the the DT cord-262511-96xp1v0r 25 15 review review NN cord-262511-96xp1v0r 25 16 is be VBZ cord-262511-96xp1v0r 25 17 structured structure VBN cord-262511-96xp1v0r 25 18 in in IN cord-262511-96xp1v0r 25 19 such such PDT cord-262511-96xp1v0r 25 20 a a DT cord-262511-96xp1v0r 25 21 way way NN cord-262511-96xp1v0r 25 22 that that WDT cord-262511-96xp1v0r 25 23 reflects reflect VBZ cord-262511-96xp1v0r 25 24 key key JJ cord-262511-96xp1v0r 25 25 functions function NNS cord-262511-96xp1v0r 25 26 of of IN cord-262511-96xp1v0r 25 27 the the DT cord-262511-96xp1v0r 25 28 immune immune JJ cord-262511-96xp1v0r 25 29 cells cell NNS cord-262511-96xp1v0r 25 30 , , , cord-262511-96xp1v0r 25 31 including include VBG cord-262511-96xp1v0r 25 32 recognition recognition NN cord-262511-96xp1v0r 25 33 by by IN cord-262511-96xp1v0r 25 34 innate innate JJ cord-262511-96xp1v0r 25 35 immunity immunity NN cord-262511-96xp1v0r 25 36 and and CC cord-262511-96xp1v0r 25 37 T T NNP cord-262511-96xp1v0r 25 38 cell cell NN cord-262511-96xp1v0r 25 39 activation activation NN cord-262511-96xp1v0r 25 40 . . . cord-262511-96xp1v0r 26 1 Signaling signal VBG cord-262511-96xp1v0r 26 2 pathways pathway NNS cord-262511-96xp1v0r 26 3 that that WDT cord-262511-96xp1v0r 26 4 tend tend VBP cord-262511-96xp1v0r 26 5 to to TO cord-262511-96xp1v0r 26 6 stabilize stabilize VB cord-262511-96xp1v0r 26 7 ARE ARE NNS cord-262511-96xp1v0r 26 8 - - : cord-262511-96xp1v0r 26 9 mRNAs mRNAs NNPS cord-262511-96xp1v0r 26 10 are be VBP cord-262511-96xp1v0r 26 11 multiple multiple JJ cord-262511-96xp1v0r 26 12 and and CC cord-262511-96xp1v0r 26 13 include include VBP cord-262511-96xp1v0r 26 14 p38 p38 CD cord-262511-96xp1v0r 26 15 MAPK MAPK NNP cord-262511-96xp1v0r 26 16 , , , cord-262511-96xp1v0r 26 17 ERK ERK NNP cord-262511-96xp1v0r 26 18 , , , cord-262511-96xp1v0r 27 1 c c LS cord-262511-96xp1v0r 27 2 - - : cord-262511-96xp1v0r 27 3 Jun Jun NNP cord-262511-96xp1v0r 27 4 N N NNP cord-262511-96xp1v0r 27 5 - - HYPH cord-262511-96xp1v0r 27 6 terminal terminal NN cord-262511-96xp1v0r 27 7 kinase kinase NN cord-262511-96xp1v0r 27 8 , , , cord-262511-96xp1v0r 27 9 PI-3K PI-3K NNP cord-262511-96xp1v0r 27 10 - - HYPH cord-262511-96xp1v0r 27 11 AKT AKT NNP cord-262511-96xp1v0r 27 12 , , , cord-262511-96xp1v0r 27 13 and and CC cord-262511-96xp1v0r 27 14 Wnt/ Wnt/ NNP cord-262511-96xp1v0r 27 15 ␤ ␤ XX cord-262511-96xp1v0r 28 1 -catenin -catenin : cord-262511-96xp1v0r 28 2 pathways pathway NNS cord-262511-96xp1v0r 28 3 [ [ -LRB- cord-262511-96xp1v0r 28 4 10 10 CD cord-262511-96xp1v0r 28 5 , , , cord-262511-96xp1v0r 28 6 [ [ -LRB- cord-262511-96xp1v0r 28 7 15 15 CD cord-262511-96xp1v0r 28 8 ] ] -RRB- cord-262511-96xp1v0r 28 9 [ [ -LRB- cord-262511-96xp1v0r 28 10 16 16 CD cord-262511-96xp1v0r 28 11 ] ] -RRB- cord-262511-96xp1v0r 28 12 [ [ -LRB- cord-262511-96xp1v0r 28 13 17 17 CD cord-262511-96xp1v0r 28 14 ] ] -RRB- cord-262511-96xp1v0r 28 15 . . . cord-262511-96xp1v0r 29 1 The the DT cord-262511-96xp1v0r 29 2 p38 p38 CD cord-262511-96xp1v0r 29 3 MAPK MAPK NNP cord-262511-96xp1v0r 29 4 pathway pathway NN cord-262511-96xp1v0r 29 5 is be VBZ cord-262511-96xp1v0r 29 6 one one CD cord-262511-96xp1v0r 29 7 of of IN cord-262511-96xp1v0r 29 8 the the DT cord-262511-96xp1v0r 29 9 most most RBS cord-262511-96xp1v0r 29 10 common common JJ cord-262511-96xp1v0r 29 11 pathways pathway NNS cord-262511-96xp1v0r 29 12 that that WDT cord-262511-96xp1v0r 29 13 regulates regulate VBZ cord-262511-96xp1v0r 29 14 mRNA mrna NN cord-262511-96xp1v0r 29 15 stability stability NN cord-262511-96xp1v0r 29 16 in in IN cord-262511-96xp1v0r 29 17 multiple multiple JJ cord-262511-96xp1v0r 29 18 cell cell NN cord-262511-96xp1v0r 29 19 types type NNS cord-262511-96xp1v0r 29 20 . . . cord-262511-96xp1v0r 30 1 Recent recent JJ cord-262511-96xp1v0r 30 2 work work NN cord-262511-96xp1v0r 30 3 extends extend VBZ cord-262511-96xp1v0r 30 4 the the DT cord-262511-96xp1v0r 30 5 role role NN cord-262511-96xp1v0r 30 6 of of IN cord-262511-96xp1v0r 30 7 the the DT cord-262511-96xp1v0r 30 8 p38 p38 NNP cord-262511-96xp1v0r 30 9 MAPK MAPK NNP cord-262511-96xp1v0r 30 10 pathway pathway NN cord-262511-96xp1v0r 30 11 and and CC cord-262511-96xp1v0r 30 12 its -PRON- PRP$ cord-262511-96xp1v0r 30 13 downstream downstream JJ cord-262511-96xp1v0r 30 14 target target NN cord-262511-96xp1v0r 30 15 kinase kinase NN cord-262511-96xp1v0r 30 16 , , , cord-262511-96xp1v0r 30 17 MAPK MAPK NNP cord-262511-96xp1v0r 30 18 - - HYPH cord-262511-96xp1v0r 30 19 activated activate VBN cord-262511-96xp1v0r 30 20 protein protein NN cord-262511-96xp1v0r 30 21 kinase kinase NN cord-262511-96xp1v0r 30 22 2 2 CD cord-262511-96xp1v0r 30 23 ( ( -LRB- cord-262511-96xp1v0r 30 24 MK2 MK2 NNP cord-262511-96xp1v0r 30 25 ) ) -RRB- cord-262511-96xp1v0r 30 26 [ [ -LRB- cord-262511-96xp1v0r 30 27 18 18 CD cord-262511-96xp1v0r 30 28 -22 -22 CD cord-262511-96xp1v0r 30 29 ] ] -RRB- cord-262511-96xp1v0r 30 30 . . . cord-262511-96xp1v0r 31 1 Activation activation NN cord-262511-96xp1v0r 31 2 of of IN cord-262511-96xp1v0r 31 3 the the DT cord-262511-96xp1v0r 31 4 p38 p38 NNP cord-262511-96xp1v0r 31 5 MAPK MAPK NNP cord-262511-96xp1v0r 31 6 pathway pathway NN cord-262511-96xp1v0r 31 7 drives drive VBZ cord-262511-96xp1v0r 31 8 the the DT cord-262511-96xp1v0r 31 9 accumulation accumulation NN cord-262511-96xp1v0r 31 10 of of IN cord-262511-96xp1v0r 31 11 TTP TTP NNP cord-262511-96xp1v0r 31 12 via via IN cord-262511-96xp1v0r 31 13 the the DT cord-262511-96xp1v0r 31 14 stabilization stabilization NN cord-262511-96xp1v0r 31 15 of of IN cord-262511-96xp1v0r 31 16 TTP TTP NNP cord-262511-96xp1v0r 31 17 mRNA mRNA NNP cord-262511-96xp1v0r 31 18 and and CC cord-262511-96xp1v0r 31 19 protein protein NN cord-262511-96xp1v0r 31 20 [ [ -LRB- cord-262511-96xp1v0r 31 21 18 18 CD cord-262511-96xp1v0r 31 22 -20 -20 CD cord-262511-96xp1v0r 31 23 ] ] -RRB- cord-262511-96xp1v0r 31 24 . . . cord-262511-96xp1v0r 32 1 Although although IN cord-262511-96xp1v0r 32 2 this this DT cord-262511-96xp1v0r 32 3 remains remain VBZ cord-262511-96xp1v0r 32 4 controversial controversial JJ cord-262511-96xp1v0r 32 5 [ [ -LRB- cord-262511-96xp1v0r 32 6 22 22 CD cord-262511-96xp1v0r 32 7 ] ] -RRB- cord-262511-96xp1v0r 32 8 , , , cord-262511-96xp1v0r 32 9 MK2-mediated mk2-mediate VBN cord-262511-96xp1v0r 32 10 phosphorylation phosphorylation NN cord-262511-96xp1v0r 32 11 of of IN cord-262511-96xp1v0r 32 12 TTP TTP NNP cord-262511-96xp1v0r 32 13 has have VBZ cord-262511-96xp1v0r 32 14 been be VBN cord-262511-96xp1v0r 32 15 reported report VBN cord-262511-96xp1v0r 32 16 to to TO cord-262511-96xp1v0r 32 17 impair impair VB cord-262511-96xp1v0r 32 18 its -PRON- PRP$ cord-262511-96xp1v0r 32 19 function function NN cord-262511-96xp1v0r 32 20 , , , cord-262511-96xp1v0r 32 21 possibly possibly RB cord-262511-96xp1v0r 32 22 as as IN cord-262511-96xp1v0r 32 23 a a DT cord-262511-96xp1v0r 32 24 result result NN cord-262511-96xp1v0r 32 25 of of IN cord-262511-96xp1v0r 32 26 reduced reduce VBN cord-262511-96xp1v0r 32 27 binding binding NN cord-262511-96xp1v0r 32 28 affinity affinity NN cord-262511-96xp1v0r 32 29 with with IN cord-262511-96xp1v0r 32 30 the the DT cord-262511-96xp1v0r 32 31 TNF- TNF- NNP cord-262511-96xp1v0r 32 32 ␣ ␣ NN cord-262511-96xp1v0r 33 1 ARE are VBP cord-262511-96xp1v0r 33 2 region region NN cord-262511-96xp1v0r 33 3 [ [ -LRB- cord-262511-96xp1v0r 33 4 18 18 CD cord-262511-96xp1v0r 33 5 , , , cord-262511-96xp1v0r 33 6 23 23 CD cord-262511-96xp1v0r 33 7 ] ] -RRB- cord-262511-96xp1v0r 33 8 . . . cord-262511-96xp1v0r 34 1 Another another DT cord-262511-96xp1v0r 34 2 p38 p38 NN cord-262511-96xp1v0r 34 3 MAPK MAPK NNP cord-262511-96xp1v0r 34 4 downstream downstream JJ cord-262511-96xp1v0r 34 5 target target NN cord-262511-96xp1v0r 34 6 with with IN cord-262511-96xp1v0r 34 7 structural structural JJ cord-262511-96xp1v0r 34 8 and and CC cord-262511-96xp1v0r 34 9 functional functional JJ cord-262511-96xp1v0r 34 10 similarity similarity NN cord-262511-96xp1v0r 34 11 to to IN cord-262511-96xp1v0r 34 12 MK2 MK2 NNP cord-262511-96xp1v0r 34 13 is be VBZ cord-262511-96xp1v0r 34 14 MK3 MK3 NNP cord-262511-96xp1v0r 34 15 ; ; : cord-262511-96xp1v0r 34 16 it -PRON- PRP cord-262511-96xp1v0r 34 17 is be VBZ cord-262511-96xp1v0r 34 18 thought think VBN cord-262511-96xp1v0r 34 19 to to TO cord-262511-96xp1v0r 34 20 cooperate cooperate VB cord-262511-96xp1v0r 34 21 with with IN cord-262511-96xp1v0r 34 22 MK2 MK2 NNP cord-262511-96xp1v0r 34 23 in in IN cord-262511-96xp1v0r 35 1 TNF- TNF- NNP cord-262511-96xp1v0r 35 2 ␣ ␣ NNP cord-262511-96xp1v0r 35 3 mRNA mrna NN cord-262511-96xp1v0r 35 4 stabilization stabilization NN cord-262511-96xp1v0r 35 5 [ [ -LRB- cord-262511-96xp1v0r 35 6 24 24 CD cord-262511-96xp1v0r 35 7 ] ] -RRB- cord-262511-96xp1v0r 35 8 . . . cord-262511-96xp1v0r 36 1 TTP TTP NNP cord-262511-96xp1v0r 36 2 and and CC cord-262511-96xp1v0r 36 3 other other JJ cord-262511-96xp1v0r 36 4 RNA RNA NNP cord-262511-96xp1v0r 36 5 decaypromoting decaypromoting NN cord-262511-96xp1v0r 36 6 proteins protein NNS cord-262511-96xp1v0r 36 7 , , , cord-262511-96xp1v0r 36 8 namely namely RB cord-262511-96xp1v0r 36 9 BRF1 BRF1 NNP cord-262511-96xp1v0r 36 10 , , , cord-262511-96xp1v0r 36 11 KSRP KSRP NNP cord-262511-96xp1v0r 36 12 , , , cord-262511-96xp1v0r 36 13 and and CC cord-262511-96xp1v0r 36 14 AUF1 AUF1 NNP cord-262511-96xp1v0r 36 15 , , , cord-262511-96xp1v0r 36 16 particularly particularly RB cord-262511-96xp1v0r 36 17 when when WRB cord-262511-96xp1v0r 36 18 phosphorylated phosphorylate VBN cord-262511-96xp1v0r 36 19 , , , cord-262511-96xp1v0r 36 20 are be VBP cord-262511-96xp1v0r 36 21 complexed complexe VBN cord-262511-96xp1v0r 36 22 with with IN cord-262511-96xp1v0r 36 23 14 14 CD cord-262511-96xp1v0r 36 24 - - SYM cord-262511-96xp1v0r 36 25 3 3 CD cord-262511-96xp1v0r 36 26 - - SYM cord-262511-96xp1v0r 36 27 3 3 CD cord-262511-96xp1v0r 36 28 proteins protein NNS cord-262511-96xp1v0r 36 29 that that WDT cord-262511-96xp1v0r 36 30 influence influence VBP cord-262511-96xp1v0r 36 31 their -PRON- PRP$ cord-262511-96xp1v0r 36 32 subcellular subcellular JJ cord-262511-96xp1v0r 36 33 localization localization NN cord-262511-96xp1v0r 36 34 and and CC cord-262511-96xp1v0r 36 35 mRNA mrna NN cord-262511-96xp1v0r 36 36 decay decay NN cord-262511-96xp1v0r 36 37 activity activity NN cord-262511-96xp1v0r 36 38 [ [ -LRB- cord-262511-96xp1v0r 36 39 10 10 CD cord-262511-96xp1v0r 36 40 , , , cord-262511-96xp1v0r 36 41 16 16 CD cord-262511-96xp1v0r 36 42 , , , cord-262511-96xp1v0r 36 43 25 25 CD cord-262511-96xp1v0r 36 44 ] ] -RRB- cord-262511-96xp1v0r 36 45 . . . cord-262511-96xp1v0r 37 1 Another another DT cord-262511-96xp1v0r 37 2 player player NN cord-262511-96xp1v0r 37 3 in in IN cord-262511-96xp1v0r 37 4 the the DT cord-262511-96xp1v0r 37 5 post post JJ cord-262511-96xp1v0r 37 6 - - JJ cord-262511-96xp1v0r 37 7 transcriptional transcriptional JJ cord-262511-96xp1v0r 37 8 regulation regulation NN cord-262511-96xp1v0r 37 9 of of IN cord-262511-96xp1v0r 37 10 the the DT cord-262511-96xp1v0r 37 11 immune immune JJ cord-262511-96xp1v0r 37 12 system system NN cord-262511-96xp1v0r 37 13 by by IN cord-262511-96xp1v0r 37 14 the the DT cord-262511-96xp1v0r 37 15 p38 p38 NNP cord-262511-96xp1v0r 37 16 MAPK MAPK NNP cord-262511-96xp1v0r 37 17 pathway pathway NN cord-262511-96xp1v0r 37 18 is be VBZ cord-262511-96xp1v0r 37 19 the the DT cord-262511-96xp1v0r 37 20 downstream downstream JJ cord-262511-96xp1v0r 37 21 MAPK mapk NN cord-262511-96xp1v0r 37 22 signal signal NN cord-262511-96xp1v0r 37 23 - - HYPH cord-262511-96xp1v0r 37 24 integrating integrate VBG cord-262511-96xp1v0r 37 25 kinase kinase NN cord-262511-96xp1v0r 37 26 , , , cord-262511-96xp1v0r 37 27 mnk1 mnk1 NN cord-262511-96xp1v0r 37 28 ; ; : cord-262511-96xp1v0r 37 29 this this DT cord-262511-96xp1v0r 37 30 kinase kinase NN cord-262511-96xp1v0r 37 31 is be VBZ cord-262511-96xp1v0r 37 32 thought think VBN cord-262511-96xp1v0r 37 33 to to TO cord-262511-96xp1v0r 37 34 phosphorylate phosphorylate VB cord-262511-96xp1v0r 37 35 the the DT cord-262511-96xp1v0r 37 36 eukaryotic eukaryotic JJ cord-262511-96xp1v0r 37 37 initiation initiation NN cord-262511-96xp1v0r 37 38 factor factor NN cord-262511-96xp1v0r 37 39 4E 4E NNP cord-262511-96xp1v0r 37 40 ( ( -LRB- cord-262511-96xp1v0r 37 41 eIF4E eif4e CD cord-262511-96xp1v0r 37 42 ) ) -RRB- cord-262511-96xp1v0r 37 43 and and CC cord-262511-96xp1v0r 37 44 heterogeneous heterogeneous JJ cord-262511-96xp1v0r 37 45 nuclear nuclear JJ cord-262511-96xp1v0r 37 46 ribonucleoprotein ribonucleoprotein NN cord-262511-96xp1v0r 37 47 A1 A1 NNP cord-262511-96xp1v0r 37 48 [ [ -LRB- cord-262511-96xp1v0r 37 49 26 26 CD cord-262511-96xp1v0r 37 50 , , , cord-262511-96xp1v0r 37 51 27 27 CD cord-262511-96xp1v0r 37 52 ] ] -RRB- cord-262511-96xp1v0r 37 53 . . . cord-262511-96xp1v0r 38 1 The the DT cord-262511-96xp1v0r 38 2 p38 p38 CD cord-262511-96xp1v0r 38 3 MAPK MAPK NNP cord-262511-96xp1v0r 38 4 pathway pathway NN cord-262511-96xp1v0r 38 5 is be VBZ cord-262511-96xp1v0r 38 6 central central JJ cord-262511-96xp1v0r 38 7 to to IN cord-262511-96xp1v0r 38 8 the the DT cord-262511-96xp1v0r 38 9 stabilization stabilization NN cord-262511-96xp1v0r 38 10 of of IN cord-262511-96xp1v0r 38 11 many many JJ cord-262511-96xp1v0r 38 12 immune immune JJ cord-262511-96xp1v0r 38 13 system system NN cord-262511-96xp1v0r 38 14 mRNAs mrnas XX cord-262511-96xp1v0r 38 15 such such JJ cord-262511-96xp1v0r 38 16 as as IN cord-262511-96xp1v0r 38 17 those those DT cord-262511-96xp1v0r 38 18 of of IN cord-262511-96xp1v0r 38 19 cytokines cytokine NNS cord-262511-96xp1v0r 38 20 during during IN cord-262511-96xp1v0r 38 21 innate innate JJ cord-262511-96xp1v0r 38 22 and and CC cord-262511-96xp1v0r 38 23 adaptive adaptive JJ cord-262511-96xp1v0r 38 24 immune immune JJ cord-262511-96xp1v0r 38 25 responses response NNS cord-262511-96xp1v0r 38 26 . . . cord-262511-96xp1v0r 39 1 Cytokines cytokine NNS cord-262511-96xp1v0r 39 2 can can MD cord-262511-96xp1v0r 39 3 regulate regulate VB cord-262511-96xp1v0r 39 4 immune immune JJ cord-262511-96xp1v0r 39 5 response response NN cord-262511-96xp1v0r 39 6 via via IN cord-262511-96xp1v0r 39 7 positive positive JJ cord-262511-96xp1v0r 39 8 - - HYPH cord-262511-96xp1v0r 39 9 and and CC cord-262511-96xp1v0r 39 10 negative negative JJ cord-262511-96xp1v0r 39 11 - - HYPH cord-262511-96xp1v0r 39 12 feedback feedback NN cord-262511-96xp1v0r 39 13 circuits circuit NNS cord-262511-96xp1v0r 39 14 . . . cord-262511-96xp1v0r 40 1 In in IN cord-262511-96xp1v0r 40 2 general general JJ cord-262511-96xp1v0r 40 3 , , , cord-262511-96xp1v0r 40 4 when when WRB cord-262511-96xp1v0r 40 5 cytokines cytokine NNS cord-262511-96xp1v0r 40 6 amplify amplify VBP cord-262511-96xp1v0r 40 7 a a DT cord-262511-96xp1v0r 40 8 specific specific JJ cord-262511-96xp1v0r 40 9 immune immune JJ cord-262511-96xp1v0r 40 10 response response NN cord-262511-96xp1v0r 40 11 , , , cord-262511-96xp1v0r 40 12 they -PRON- PRP cord-262511-96xp1v0r 40 13 tend tend VBP cord-262511-96xp1v0r 40 14 to to TO cord-262511-96xp1v0r 40 15 stabilize stabilize VB cord-262511-96xp1v0r 40 16 mRNAs mrnas XX cord-262511-96xp1v0r 40 17 that that WDT cord-262511-96xp1v0r 40 18 participate participate VBP cord-262511-96xp1v0r 40 19 in in IN cord-262511-96xp1v0r 40 20 such such PDT cord-262511-96xp1v0r 40 21 a a DT cord-262511-96xp1v0r 40 22 process process NN cord-262511-96xp1v0r 40 23 . . . cord-262511-96xp1v0r 41 1 Examples example NNS cord-262511-96xp1v0r 41 2 of of IN cord-262511-96xp1v0r 41 3 those those DT cord-262511-96xp1v0r 41 4 cytokines cytokine NNS cord-262511-96xp1v0r 41 5 are be VBP cord-262511-96xp1v0r 41 6 the the DT cord-262511-96xp1v0r 41 7 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 41 8 cytokines cytokine NNS cord-262511-96xp1v0r 41 9 , , , cord-262511-96xp1v0r 42 1 IL-1 IL-1 NNP cord-262511-96xp1v0r 42 2 ␣ ␣ NNP cord-262511-96xp1v0r 42 3 and and CC cord-262511-96xp1v0r 42 4 TNF- TNF- NNP cord-262511-96xp1v0r 42 5 ␣ ␣ NNP cord-262511-96xp1v0r 42 6 , , , cord-262511-96xp1v0r 42 7 which which WDT cord-262511-96xp1v0r 42 8 have have VBP cord-262511-96xp1v0r 42 9 been be VBN cord-262511-96xp1v0r 42 10 found find VBN cord-262511-96xp1v0r 42 11 to to TO cord-262511-96xp1v0r 42 12 stabilize stabilize VB cord-262511-96xp1v0r 42 13 a a DT cord-262511-96xp1v0r 42 14 significant significant JJ cord-262511-96xp1v0r 42 15 number number NN cord-262511-96xp1v0r 42 16 of of IN cord-262511-96xp1v0r 42 17 cytokines cytokine NNS cord-262511-96xp1v0r 42 18 and and CC cord-262511-96xp1v0r 42 19 chemokines chemokine NNS cord-262511-96xp1v0r 42 20 , , , cord-262511-96xp1v0r 42 21 including include VBG cord-262511-96xp1v0r 42 22 IFN- IFN- NNP cord-262511-96xp1v0r 42 23 ␥ ␥ CD cord-262511-96xp1v0r 42 24 -inducible -inducible JJ cord-262511-96xp1v0r 42 25 protein protein NN cord-262511-96xp1v0r 42 26 10 10 CD cord-262511-96xp1v0r 42 27 ( ( -LRB- cord-262511-96xp1v0r 42 28 IP-10 IP-10 NNP cord-262511-96xp1v0r 42 29 ) ) -RRB- cord-262511-96xp1v0r 42 30 , , , cord-262511-96xp1v0r 42 31 growth growth NN cord-262511-96xp1v0r 42 32 - - HYPH cord-262511-96xp1v0r 42 33 related relate VBN cord-262511-96xp1v0r 42 34 oncogene oncogene NN cord-262511-96xp1v0r 42 35 proteins protein NNS cord-262511-96xp1v0r 42 36 , , , cord-262511-96xp1v0r 42 37 and and CC cord-262511-96xp1v0r 42 38 fractalkine fractalkine JJ cord-262511-96xp1v0r 42 39 ( ( -LRB- cord-262511-96xp1v0r 42 40 SCYD1 SCYD1 NNP cord-262511-96xp1v0r 42 41 ) ) -RRB- cord-262511-96xp1v0r 42 42 , , , cord-262511-96xp1v0r 42 43 and and CC cord-262511-96xp1v0r 42 44 several several JJ cord-262511-96xp1v0r 42 45 genes gene NNS cord-262511-96xp1v0r 42 46 involved involve VBN cord-262511-96xp1v0r 42 47 in in IN cord-262511-96xp1v0r 42 48 regulation regulation NN cord-262511-96xp1v0r 42 49 of of IN cord-262511-96xp1v0r 42 50 inflammatory inflammatory JJ cord-262511-96xp1v0r 42 51 responses response NNS cord-262511-96xp1v0r 42 52 such such JJ cord-262511-96xp1v0r 42 53 as as IN cord-262511-96xp1v0r 42 54 TNF- TNF- NNP cord-262511-96xp1v0r 42 55 ␣ ␣ NNP cord-262511-96xp1v0r 42 56 -induced -induce VBD cord-262511-96xp1v0r 42 57 protein protein NN cord-262511-96xp1v0r 42 58 3 3 CD cord-262511-96xp1v0r 42 59 , , , cord-262511-96xp1v0r 42 60 NF nf NN cord-262511-96xp1v0r 42 61 - - HYPH cord-262511-96xp1v0r 42 62 B b NN cord-262511-96xp1v0r 43 1 ␣ ␣ NNP cord-262511-96xp1v0r 43 2 I -PRON- PRP cord-262511-96xp1v0r 43 3 , , , cord-262511-96xp1v0r 43 4 and and CC cord-262511-96xp1v0r 43 5 mannose mannose NN cord-262511-96xp1v0r 43 6 - - HYPH cord-262511-96xp1v0r 43 7 binding bind VBG cord-262511-96xp1v0r 43 8 lectin lectin NN cord-262511-96xp1v0r 43 9 2 2 CD cord-262511-96xp1v0r 43 10 ( ( -LRB- cord-262511-96xp1v0r 43 11 MBL2 MBL2 NNP cord-262511-96xp1v0r 43 12 ) ) -RRB- cord-262511-96xp1v0r 44 1 [ [ -LRB- cord-262511-96xp1v0r 44 2 28 28 CD cord-262511-96xp1v0r 44 3 -30 -30 CD cord-262511-96xp1v0r 44 4 ] ] -RRB- cord-262511-96xp1v0r 44 5 . . . cord-262511-96xp1v0r 45 1 Cytokines cytokine NNS cord-262511-96xp1v0r 45 2 use use VBP cord-262511-96xp1v0r 45 3 p38 p38 CD cord-262511-96xp1v0r 45 4 MAPK MAPK NNP cord-262511-96xp1v0r 45 5 signaling signal VBG cord-262511-96xp1v0r 45 6 and and CC cord-262511-96xp1v0r 45 7 notably notably RB cord-262511-96xp1v0r 45 8 , , , cord-262511-96xp1v0r 45 9 its -PRON- PRP$ cord-262511-96xp1v0r 45 10 target target NN cord-262511-96xp1v0r 45 11 MK2 MK2 NNP cord-262511-96xp1v0r 45 12 to to TO cord-262511-96xp1v0r 45 13 trigger trigger VB cord-262511-96xp1v0r 45 14 mRNA mRNA NNP cord-262511-96xp1v0r 45 15 stabilization stabilization NN cord-262511-96xp1v0r 45 16 . . . cord-262511-96xp1v0r 46 1 For for IN cord-262511-96xp1v0r 46 2 example example NN cord-262511-96xp1v0r 46 3 , , , cord-262511-96xp1v0r 46 4 using use VBG cord-262511-96xp1v0r 46 5 this this DT cord-262511-96xp1v0r 46 6 pathway pathway NN cord-262511-96xp1v0r 46 7 , , , cord-262511-96xp1v0r 46 8 IFN- IFN- NNP cord-262511-96xp1v0r 46 9 ␥ ␥ NNP cord-262511-96xp1v0r 46 10 amplifies amplify VBZ cord-262511-96xp1v0r 46 11 immune immune JJ cord-262511-96xp1v0r 46 12 responses response NNS cord-262511-96xp1v0r 46 13 such such JJ cord-262511-96xp1v0r 46 14 as as IN cord-262511-96xp1v0r 46 15 increasing increase VBG cord-262511-96xp1v0r 46 16 NK NK NNP cord-262511-96xp1v0r 46 17 activity activity NN cord-262511-96xp1v0r 46 18 and and CC cord-262511-96xp1v0r 46 19 up up RB cord-262511-96xp1v0r 46 20 - - HYPH cord-262511-96xp1v0r 46 21 regulating regulate VBG cord-262511-96xp1v0r 46 22 MHC MHC NNP cord-262511-96xp1v0r 46 23 expression expression NN cord-262511-96xp1v0r 46 24 [ [ -LRB- cord-262511-96xp1v0r 46 25 31 31 CD cord-262511-96xp1v0r 46 26 ] ] -RRB- cord-262511-96xp1v0r 46 27 . . . cord-262511-96xp1v0r 47 1 In in IN cord-262511-96xp1v0r 47 2 several several JJ cord-262511-96xp1v0r 47 3 inflammatory inflammatory JJ cord-262511-96xp1v0r 47 4 conditions condition NNS cord-262511-96xp1v0r 47 5 , , , cord-262511-96xp1v0r 47 6 other other JJ cord-262511-96xp1v0r 47 7 cytokines cytokine NNS cord-262511-96xp1v0r 47 8 can can MD cord-262511-96xp1v0r 47 9 amplify amplify VB cord-262511-96xp1v0r 47 10 inflammatory inflammatory JJ cord-262511-96xp1v0r 47 11 responses response NNS cord-262511-96xp1v0r 47 12 via via IN cord-262511-96xp1v0r 47 13 post post JJ cord-262511-96xp1v0r 47 14 - - JJ cord-262511-96xp1v0r 47 15 transcriptional transcriptional JJ cord-262511-96xp1v0r 47 16 mechanisms mechanism NNS cord-262511-96xp1v0r 47 17 . . . cord-262511-96xp1v0r 48 1 IL-17A il-17a NN cord-262511-96xp1v0r 48 2 , , , cord-262511-96xp1v0r 48 3 in in IN cord-262511-96xp1v0r 48 4 a a DT cord-262511-96xp1v0r 48 5 p38 p38 CD cord-262511-96xp1v0r 48 6 MAPK MAPK NNP cord-262511-96xp1v0r 48 7 - - HYPH cord-262511-96xp1v0r 48 8 dependent dependent JJ cord-262511-96xp1v0r 48 9 manner manner NN cord-262511-96xp1v0r 48 10 , , , cord-262511-96xp1v0r 48 11 can can MD cord-262511-96xp1v0r 48 12 increase increase VB cord-262511-96xp1v0r 48 13 the the DT cord-262511-96xp1v0r 48 14 stability stability NN cord-262511-96xp1v0r 48 15 of of IN cord-262511-96xp1v0r 49 1 TNF- tnf- JJ cord-262511-96xp1v0r 49 2 ␣ ␣ NN cord-262511-96xp1v0r 49 3 -induced -induce VBN cord-262511-96xp1v0r 50 1 IL-8 IL-8 NNP cord-262511-96xp1v0r 51 1 mRNA mRNA NNP cord-262511-96xp1v0r 51 2 in in IN cord-262511-96xp1v0r 51 3 human human JJ cord-262511-96xp1v0r 51 4 airway airway NN cord-262511-96xp1v0r 51 5 smooth smooth JJ cord-262511-96xp1v0r 51 6 muscle muscle NN cord-262511-96xp1v0r 51 7 , , , cord-262511-96xp1v0r 51 8 a a DT cord-262511-96xp1v0r 51 9 process process NN cord-262511-96xp1v0r 51 10 that that WDT cord-262511-96xp1v0r 51 11 is be VBZ cord-262511-96xp1v0r 51 12 important important JJ cord-262511-96xp1v0r 51 13 in in IN cord-262511-96xp1v0r 51 14 development development NN cord-262511-96xp1v0r 51 15 of of IN cord-262511-96xp1v0r 51 16 asthma asthma NN cord-262511-96xp1v0r 51 17 [ [ -LRB- cord-262511-96xp1v0r 51 18 32 32 CD cord-262511-96xp1v0r 51 19 , , , cord-262511-96xp1v0r 51 20 33 33 CD cord-262511-96xp1v0r 51 21 ] ] -RRB- cord-262511-96xp1v0r 51 22 . . . cord-262511-96xp1v0r 52 1 IL-1 IL-1 NNP cord-262511-96xp1v0r 52 2 , , , cord-262511-96xp1v0r 52 3 in in IN cord-262511-96xp1v0r 52 4 addition addition NN cord-262511-96xp1v0r 52 5 to to IN cord-262511-96xp1v0r 52 6 activated activate VBN cord-262511-96xp1v0r 52 7 platelets platelet NNS cord-262511-96xp1v0r 52 8 , , , cord-262511-96xp1v0r 52 9 triggers trigger VBZ cord-262511-96xp1v0r 52 10 stabilization stabilization NN cord-262511-96xp1v0r 52 11 of of IN cord-262511-96xp1v0r 52 12 cyclooxygenase cyclooxygenase NN cord-262511-96xp1v0r 52 13 2 2 CD cord-262511-96xp1v0r 53 1 ( ( -LRB- cord-262511-96xp1v0r 53 2 COX-2 COX-2 NNP cord-262511-96xp1v0r 53 3 ) ) -RRB- cord-262511-96xp1v0r 54 1 mRNA mrna NN cord-262511-96xp1v0r 54 2 with with IN cord-262511-96xp1v0r 54 3 concomitant concomitant JJ cord-262511-96xp1v0r 54 4 cytoplasmic cytoplasmic JJ cord-262511-96xp1v0r 54 5 accumulation accumulation NN cord-262511-96xp1v0r 54 6 and and CC cord-262511-96xp1v0r 54 7 increased increase VBN cord-262511-96xp1v0r 54 8 binding binding NN cord-262511-96xp1v0r 54 9 of of IN cord-262511-96xp1v0r 54 10 HuR hur NN cord-262511-96xp1v0r 54 11 to to IN cord-262511-96xp1v0r 54 12 the the DT cord-262511-96xp1v0r 54 13 AREs are NNS cord-262511-96xp1v0r 54 14 of of IN cord-262511-96xp1v0r 54 15 COX-2 COX-2 NNP cord-262511-96xp1v0r 54 16 mRNA mrna NN cord-262511-96xp1v0r 54 17 in in IN cord-262511-96xp1v0r 54 18 monocytes monocyte NNS cord-262511-96xp1v0r 54 19 [ [ -LRB- cord-262511-96xp1v0r 54 20 33 33 CD cord-262511-96xp1v0r 54 21 ] ] -RRB- cord-262511-96xp1v0r 54 22 . . . cord-262511-96xp1v0r 55 1 In in IN cord-262511-96xp1v0r 55 2 general general JJ cord-262511-96xp1v0r 55 3 , , , cord-262511-96xp1v0r 55 4 stabilization stabilization NN cord-262511-96xp1v0r 55 5 of of IN cord-262511-96xp1v0r 55 6 the the DT cord-262511-96xp1v0r 55 7 mRNA mRNA NNP cord-262511-96xp1v0r 55 8 targets target NNS cord-262511-96xp1v0r 55 9 seems seem VBZ cord-262511-96xp1v0r 55 10 to to TO cord-262511-96xp1v0r 55 11 occur occur VB cord-262511-96xp1v0r 55 12 after after IN cord-262511-96xp1v0r 55 13 translocation translocation NN cord-262511-96xp1v0r 55 14 of of IN cord-262511-96xp1v0r 55 15 HuR hur NN cord-262511-96xp1v0r 55 16 from from IN cord-262511-96xp1v0r 55 17 the the DT cord-262511-96xp1v0r 55 18 nucleus nucleus NN cord-262511-96xp1v0r 55 19 to to IN cord-262511-96xp1v0r 55 20 the the DT cord-262511-96xp1v0r 55 21 cytoplasm cytoplasm NN cord-262511-96xp1v0r 55 22 upon upon IN cord-262511-96xp1v0r 55 23 cellular cellular JJ cord-262511-96xp1v0r 55 24 activation activation NN cord-262511-96xp1v0r 55 25 [ [ -LRB- cord-262511-96xp1v0r 55 26 34 34 CD cord-262511-96xp1v0r 55 27 ] ] -RRB- cord-262511-96xp1v0r 55 28 . . . cord-262511-96xp1v0r 56 1 Innate innate JJ cord-262511-96xp1v0r 56 2 immunity immunity NN cord-262511-96xp1v0r 56 3 is be VBZ cord-262511-96xp1v0r 56 4 the the DT cord-262511-96xp1v0r 56 5 first first JJ cord-262511-96xp1v0r 56 6 line line NN cord-262511-96xp1v0r 56 7 of of IN cord-262511-96xp1v0r 56 8 defense defense NN cord-262511-96xp1v0r 56 9 against against IN cord-262511-96xp1v0r 56 10 microbes microbe NNS cord-262511-96xp1v0r 56 11 and and CC cord-262511-96xp1v0r 56 12 requires require VBZ cord-262511-96xp1v0r 56 13 early early JJ cord-262511-96xp1v0r 56 14 and and CC cord-262511-96xp1v0r 56 15 rapid rapid JJ cord-262511-96xp1v0r 56 16 gene gene NN cord-262511-96xp1v0r 56 17 expression expression NN cord-262511-96xp1v0r 56 18 of of IN cord-262511-96xp1v0r 56 19 effector effector JJ cord-262511-96xp1v0r 56 20 mediators mediator NNS cord-262511-96xp1v0r 56 21 to to TO cord-262511-96xp1v0r 56 22 control control VB cord-262511-96xp1v0r 56 23 infection infection NN cord-262511-96xp1v0r 56 24 effectively effectively RB cord-262511-96xp1v0r 56 25 . . . cord-262511-96xp1v0r 57 1 Recognition recognition NN cord-262511-96xp1v0r 57 2 and and CC cord-262511-96xp1v0r 57 3 effector effector NN cord-262511-96xp1v0r 57 4 mechanisms mechanism NNS cord-262511-96xp1v0r 57 5 of of IN cord-262511-96xp1v0r 57 6 innate innate JJ cord-262511-96xp1v0r 57 7 immunity immunity NN cord-262511-96xp1v0r 57 8 encompass encompass VBP cord-262511-96xp1v0r 57 9 post post JJ cord-262511-96xp1v0r 57 10 - - JJ cord-262511-96xp1v0r 57 11 transcriptional transcriptional JJ cord-262511-96xp1v0r 57 12 gene gene NN cord-262511-96xp1v0r 57 13 regulation regulation NN cord-262511-96xp1v0r 57 14 , , , cord-262511-96xp1v0r 57 15 which which WDT cord-262511-96xp1v0r 57 16 amplifies amplify VBZ cord-262511-96xp1v0r 57 17 the the DT cord-262511-96xp1v0r 57 18 much much RB cord-262511-96xp1v0r 57 19 - - HYPH cord-262511-96xp1v0r 57 20 needed need VBN cord-262511-96xp1v0r 57 21 , , , cord-262511-96xp1v0r 57 22 early early JJ cord-262511-96xp1v0r 57 23 response response NN cord-262511-96xp1v0r 57 24 and and CC cord-262511-96xp1v0r 57 25 enforces enforce VBZ cord-262511-96xp1v0r 57 26 the the DT cord-262511-96xp1v0r 57 27 transient transient JJ cord-262511-96xp1v0r 57 28 response response NN cord-262511-96xp1v0r 57 29 . . . cord-262511-96xp1v0r 58 1 Efficient efficient JJ cord-262511-96xp1v0r 58 2 recognition recognition NN cord-262511-96xp1v0r 58 3 of of IN cord-262511-96xp1v0r 58 4 the the DT cord-262511-96xp1v0r 58 5 foreign foreign JJ cord-262511-96xp1v0r 58 6 antigens antigen NNS cord-262511-96xp1v0r 58 7 in in IN cord-262511-96xp1v0r 58 8 microbes microbe NNS cord-262511-96xp1v0r 58 9 , , , cord-262511-96xp1v0r 58 10 such such JJ cord-262511-96xp1v0r 58 11 as as IN cord-262511-96xp1v0r 58 12 bacterial bacterial JJ cord-262511-96xp1v0r 58 13 surface surface NN cord-262511-96xp1v0r 58 14 molecules molecule NNS cord-262511-96xp1v0r 58 15 and and CC cord-262511-96xp1v0r 58 16 viral viral JJ cord-262511-96xp1v0r 58 17 dsRNA dsrna NN cord-262511-96xp1v0r 58 18 , , , cord-262511-96xp1v0r 58 19 is be VBZ cord-262511-96xp1v0r 58 20 accomplished accomplish VBN cord-262511-96xp1v0r 58 21 by by IN cord-262511-96xp1v0r 58 22 cells cell NNS cord-262511-96xp1v0r 58 23 of of IN cord-262511-96xp1v0r 58 24 the the DT cord-262511-96xp1v0r 58 25 innate innate JJ cord-262511-96xp1v0r 58 26 immunity immunity NN cord-262511-96xp1v0r 58 27 , , , cord-262511-96xp1v0r 58 28 notably notably RB cord-262511-96xp1v0r 58 29 macrophages macrophage NNS cord-262511-96xp1v0r 58 30 and and CC cord-262511-96xp1v0r 58 31 dendritic dendritic JJ cord-262511-96xp1v0r 58 32 cells cell NNS cord-262511-96xp1v0r 58 33 ( ( -LRB- cord-262511-96xp1v0r 58 34 DC DC NNP cord-262511-96xp1v0r 58 35 ) ) -RRB- cord-262511-96xp1v0r 58 36 . . . cord-262511-96xp1v0r 59 1 Members member NNS cord-262511-96xp1v0r 59 2 of of IN cord-262511-96xp1v0r 59 3 the the DT cord-262511-96xp1v0r 59 4 TLR TLR NNP cord-262511-96xp1v0r 59 5 family family NN cord-262511-96xp1v0r 59 6 [ [ -LRB- cord-262511-96xp1v0r 59 7 35 35 CD cord-262511-96xp1v0r 59 8 , , , cord-262511-96xp1v0r 59 9 36 36 CD cord-262511-96xp1v0r 59 10 ] ] -RRB- cord-262511-96xp1v0r 59 11 , , , cord-262511-96xp1v0r 59 12 which which WDT cord-262511-96xp1v0r 59 13 have have VBP cord-262511-96xp1v0r 59 14 gained gain VBN cord-262511-96xp1v0r 59 15 considerable considerable JJ cord-262511-96xp1v0r 59 16 attention attention NN cord-262511-96xp1v0r 59 17 in in IN cord-262511-96xp1v0r 59 18 recent recent JJ cord-262511-96xp1v0r 59 19 years year NNS cord-262511-96xp1v0r 59 20 , , , cord-262511-96xp1v0r 59 21 are be VBP cord-262511-96xp1v0r 59 22 responsible responsible JJ cord-262511-96xp1v0r 59 23 for for IN cord-262511-96xp1v0r 59 24 triggering trigger VBG cord-262511-96xp1v0r 59 25 the the DT cord-262511-96xp1v0r 59 26 efficient efficient JJ cord-262511-96xp1v0r 59 27 response response NN cord-262511-96xp1v0r 59 28 of of IN cord-262511-96xp1v0r 59 29 the the DT cord-262511-96xp1v0r 59 30 host host NN cord-262511-96xp1v0r 59 31 cell cell NN cord-262511-96xp1v0r 59 32 to to IN cord-262511-96xp1v0r 59 33 microbes microbe NNS cord-262511-96xp1v0r 59 34 . . . cord-262511-96xp1v0r 60 1 Traditionally traditionally RB cord-262511-96xp1v0r 60 2 , , , cord-262511-96xp1v0r 60 3 post post JJ cord-262511-96xp1v0r 60 4 - - JJ cord-262511-96xp1v0r 60 5 transcriptional transcriptional JJ cord-262511-96xp1v0r 60 6 regulation regulation NN cord-262511-96xp1v0r 60 7 in in IN cord-262511-96xp1v0r 60 8 innate innate JJ cord-262511-96xp1v0r 60 9 immunity immunity NN cord-262511-96xp1v0r 60 10 has have VBZ cord-262511-96xp1v0r 60 11 been be VBN cord-262511-96xp1v0r 60 12 studied study VBN cord-262511-96xp1v0r 60 13 in in IN cord-262511-96xp1v0r 60 14 response response NN cord-262511-96xp1v0r 60 15 to to IN cord-262511-96xp1v0r 60 16 the the DT cord-262511-96xp1v0r 60 17 bacterial bacterial JJ cord-262511-96xp1v0r 60 18 endotoxin endotoxin NN cord-262511-96xp1v0r 60 19 , , , cord-262511-96xp1v0r 60 20 LPS LPS NNP cord-262511-96xp1v0r 60 21 , , , cord-262511-96xp1v0r 60 22 which which WDT cord-262511-96xp1v0r 60 23 binds bind VBZ cord-262511-96xp1v0r 60 24 CD14 CD14 NNP cord-262511-96xp1v0r 60 25 in in IN cord-262511-96xp1v0r 60 26 a a DT cord-262511-96xp1v0r 60 27 complex complex NN cord-262511-96xp1v0r 60 28 with with IN cord-262511-96xp1v0r 60 29 TLR4 TLR4 NNP cord-262511-96xp1v0r 60 30 on on IN cord-262511-96xp1v0r 60 31 the the DT cord-262511-96xp1v0r 60 32 surface surface NN cord-262511-96xp1v0r 60 33 of of IN cord-262511-96xp1v0r 60 34 neutrophils neutrophil NNS cord-262511-96xp1v0r 60 35 and and CC cord-262511-96xp1v0r 60 36 macrophages macrophage NNS cord-262511-96xp1v0r 60 37 and and CC cord-262511-96xp1v0r 60 38 initiates initiate VBZ cord-262511-96xp1v0r 60 39 a a DT cord-262511-96xp1v0r 60 40 cascade cascade NN cord-262511-96xp1v0r 60 41 of of IN cord-262511-96xp1v0r 60 42 signals signal NNS cord-262511-96xp1v0r 60 43 that that WDT cord-262511-96xp1v0r 60 44 causes cause VBZ cord-262511-96xp1v0r 60 45 cell cell NN cord-262511-96xp1v0r 60 46 activation activation NN cord-262511-96xp1v0r 60 47 , , , cord-262511-96xp1v0r 60 48 the the DT cord-262511-96xp1v0r 60 49 inflammatory inflammatory JJ cord-262511-96xp1v0r 60 50 response response NN cord-262511-96xp1v0r 60 51 , , , cord-262511-96xp1v0r 60 52 and and CC cord-262511-96xp1v0r 60 53 phagocytosis phagocytosis NN cord-262511-96xp1v0r 60 54 [ [ -LRB- cord-262511-96xp1v0r 60 55 35 35 CD cord-262511-96xp1v0r 60 56 ] ] -RRB- cord-262511-96xp1v0r 60 57 . . . cord-262511-96xp1v0r 61 1 Recent recent JJ cord-262511-96xp1v0r 61 2 work work NN cord-262511-96xp1v0r 61 3 gives give VBZ cord-262511-96xp1v0r 61 4 further further JJ cord-262511-96xp1v0r 61 5 insights insight NNS cord-262511-96xp1v0r 61 6 into into IN cord-262511-96xp1v0r 61 7 LPS LPS NNP cord-262511-96xp1v0r 61 8 - - HYPH cord-262511-96xp1v0r 61 9 induced induce VBN cord-262511-96xp1v0r 61 10 pathways pathway NNS cord-262511-96xp1v0r 61 11 . . . cord-262511-96xp1v0r 62 1 Upon upon IN cord-262511-96xp1v0r 62 2 activation activation NN cord-262511-96xp1v0r 62 3 of of IN cord-262511-96xp1v0r 62 4 TLR4 TLR4 NNP cord-262511-96xp1v0r 62 5 by by IN cord-262511-96xp1v0r 62 6 LPS LPS NNP cord-262511-96xp1v0r 62 7 , , , cord-262511-96xp1v0r 62 8 the the DT cord-262511-96xp1v0r 62 9 adaptor adaptor NN cord-262511-96xp1v0r 62 10 protein protein NN cord-262511-96xp1v0r 62 11 MyD88 MyD88 NNS cord-262511-96xp1v0r 62 12 is be VBZ cord-262511-96xp1v0r 62 13 recruited recruit VBN cord-262511-96xp1v0r 62 14 to to IN cord-262511-96xp1v0r 62 15 the the DT cord-262511-96xp1v0r 62 16 receptor receptor NN cord-262511-96xp1v0r 62 17 and and CC cord-262511-96xp1v0r 62 18 couples couple NNS cord-262511-96xp1v0r 62 19 with with IN cord-262511-96xp1v0r 62 20 IL-1 IL-1 NNP cord-262511-96xp1v0r 62 21 receptor receptor NN cord-262511-96xp1v0r 62 22 - - HYPH cord-262511-96xp1v0r 62 23 associated associate VBN cord-262511-96xp1v0r 62 24 kinase kinase NN cord-262511-96xp1v0r 62 25 ( ( -LRB- cord-262511-96xp1v0r 62 26 IRAK)1 irak)1 NN cord-262511-96xp1v0r 62 27 and and CC cord-262511-96xp1v0r 62 28 -4 -4 NNP cord-262511-96xp1v0r 62 29 , , , cord-262511-96xp1v0r 62 30 causing cause VBG cord-262511-96xp1v0r 62 31 IRAK IRAK NNP cord-262511-96xp1v0r 62 32 activation activation NN cord-262511-96xp1v0r 62 33 and and CC cord-262511-96xp1v0r 62 34 recruitment recruitment NN cord-262511-96xp1v0r 62 35 into into IN cord-262511-96xp1v0r 62 36 a a DT cord-262511-96xp1v0r 62 37 complex complex NN cord-262511-96xp1v0r 62 38 with with IN cord-262511-96xp1v0r 62 39 TNF TNF NNP cord-262511-96xp1v0r 62 40 receptor receptor NN cord-262511-96xp1v0r 62 41 - - HYPH cord-262511-96xp1v0r 62 42 associated associate VBN cord-262511-96xp1v0r 62 43 factor factor NN cord-262511-96xp1v0r 62 44 6 6 CD cord-262511-96xp1v0r 62 45 ( ( -LRB- cord-262511-96xp1v0r 62 46 TRAF6 TRAF6 NNP cord-262511-96xp1v0r 62 47 ) ) -RRB- cord-262511-96xp1v0r 62 48 . . . cord-262511-96xp1v0r 63 1 This this DT cord-262511-96xp1v0r 63 2 pathway pathway NN cord-262511-96xp1v0r 63 3 ultimately ultimately RB cord-262511-96xp1v0r 63 4 culminates culminate VBZ cord-262511-96xp1v0r 63 5 in in IN cord-262511-96xp1v0r 63 6 a a DT cord-262511-96xp1v0r 63 7 cascade cascade NN cord-262511-96xp1v0r 63 8 of of IN cord-262511-96xp1v0r 63 9 signaling signal VBG cord-262511-96xp1v0r 63 10 events event NNS cord-262511-96xp1v0r 63 11 including include VBG cord-262511-96xp1v0r 63 12 NF nf NN cord-262511-96xp1v0r 63 13 - - HYPH cord-262511-96xp1v0r 63 14 B b NN cord-262511-96xp1v0r 63 15 activation activation NN cord-262511-96xp1v0r 63 16 , , , cord-262511-96xp1v0r 63 17 MAPK MAPK NNP cord-262511-96xp1v0r 63 18 activation activation NN cord-262511-96xp1v0r 63 19 , , , cord-262511-96xp1v0r 63 20 and and CC cord-262511-96xp1v0r 63 21 transcriptional transcriptional JJ cord-262511-96xp1v0r 63 22 activation activation NN cord-262511-96xp1v0r 63 23 of of IN cord-262511-96xp1v0r 63 24 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 63 25 cytokines cytokine NNS cord-262511-96xp1v0r 63 26 [ [ -LRB- cord-262511-96xp1v0r 63 27 37 37 CD cord-262511-96xp1v0r 63 28 ] ] -RRB- cord-262511-96xp1v0r 63 29 . . . cord-262511-96xp1v0r 64 1 Engagement engagement NN cord-262511-96xp1v0r 64 2 of of IN cord-262511-96xp1v0r 64 3 LPS LPS NNP cord-262511-96xp1v0r 64 4 with with IN cord-262511-96xp1v0r 64 5 TLR4 TLR4 NNP cord-262511-96xp1v0r 64 6 can can MD cord-262511-96xp1v0r 64 7 itself -PRON- PRP cord-262511-96xp1v0r 64 8 lead lead VB cord-262511-96xp1v0r 64 9 to to IN cord-262511-96xp1v0r 64 10 stabilization stabilization NN cord-262511-96xp1v0r 64 11 of of IN cord-262511-96xp1v0r 64 12 its -PRON- PRP$ cord-262511-96xp1v0r 64 13 own own JJ cord-262511-96xp1v0r 64 14 mRNA mrna NN cord-262511-96xp1v0r 64 15 , , , cord-262511-96xp1v0r 64 16 resulting result VBG cord-262511-96xp1v0r 64 17 in in IN cord-262511-96xp1v0r 64 18 a a DT cord-262511-96xp1v0r 64 19 LPS LPS NNP cord-262511-96xp1v0r 64 20 amplification amplification NN cord-262511-96xp1v0r 64 21 response response NN cord-262511-96xp1v0r 64 22 . . . cord-262511-96xp1v0r 65 1 Although although IN cord-262511-96xp1v0r 65 2 this this DT cord-262511-96xp1v0r 65 3 has have VBZ cord-262511-96xp1v0r 65 4 been be VBN cord-262511-96xp1v0r 65 5 shown show VBN cord-262511-96xp1v0r 65 6 in in IN cord-262511-96xp1v0r 65 7 the the DT cord-262511-96xp1v0r 65 8 case case NN cord-262511-96xp1v0r 65 9 of of IN cord-262511-96xp1v0r 65 10 vascular vascular JJ cord-262511-96xp1v0r 65 11 smooth smooth JJ cord-262511-96xp1v0r 65 12 muscle muscle NN cord-262511-96xp1v0r 65 13 cells cell NNS cord-262511-96xp1v0r 65 14 when when WRB cord-262511-96xp1v0r 65 15 exposed expose VBN cord-262511-96xp1v0r 65 16 to to IN cord-262511-96xp1v0r 65 17 LPS LPS NNP cord-262511-96xp1v0r 65 18 [ [ -LRB- cord-262511-96xp1v0r 65 19 38 38 CD cord-262511-96xp1v0r 65 20 ] ] -RRB- cord-262511-96xp1v0r 65 21 , , , cord-262511-96xp1v0r 65 22 it -PRON- PRP cord-262511-96xp1v0r 65 23 is be VBZ cord-262511-96xp1v0r 65 24 likely likely JJ cord-262511-96xp1v0r 65 25 to to TO cord-262511-96xp1v0r 65 26 occur occur VB cord-262511-96xp1v0r 65 27 with with IN cord-262511-96xp1v0r 65 28 cells cell NNS cord-262511-96xp1v0r 65 29 of of IN cord-262511-96xp1v0r 65 30 the the DT cord-262511-96xp1v0r 65 31 innate innate JJ cord-262511-96xp1v0r 65 32 immune immune JJ cord-262511-96xp1v0r 65 33 system system NN cord-262511-96xp1v0r 65 34 . . . cord-262511-96xp1v0r 66 1 TLR4 TLR4 NNP cord-262511-96xp1v0r 66 2 activation activation NN cord-262511-96xp1v0r 66 3 causes cause VBZ cord-262511-96xp1v0r 66 4 HuR HuR NNP cord-262511-96xp1v0r 66 5 translocation translocation NN cord-262511-96xp1v0r 66 6 to to IN cord-262511-96xp1v0r 66 7 the the DT cord-262511-96xp1v0r 66 8 cytoplasm cytoplasm NN cord-262511-96xp1v0r 66 9 , , , cord-262511-96xp1v0r 66 10 enhanced enhance VBN cord-262511-96xp1v0r 66 11 binding binding NN cord-262511-96xp1v0r 66 12 of of IN cord-262511-96xp1v0r 66 13 HuR hur NN cord-262511-96xp1v0r 66 14 to to IN cord-262511-96xp1v0r 66 15 the the DT cord-262511-96xp1v0r 66 16 3ЈUTR 3јutr CD cord-262511-96xp1v0r 66 17 , , , cord-262511-96xp1v0r 66 18 and and CC cord-262511-96xp1v0r 66 19 increased increase VBN cord-262511-96xp1v0r 66 20 stability stability NN cord-262511-96xp1v0r 66 21 of of IN cord-262511-96xp1v0r 66 22 TLR4 TLR4 NNP cord-262511-96xp1v0r 67 1 mRNA mRNA NNP cord-262511-96xp1v0r 67 2 [ [ -LRB- cord-262511-96xp1v0r 67 3 38 38 CD cord-262511-96xp1v0r 67 4 ] ] -RRB- cord-262511-96xp1v0r 67 5 . . . cord-262511-96xp1v0r 68 1 The the DT cord-262511-96xp1v0r 68 2 adaptor adaptor NN cord-262511-96xp1v0r 68 3 molecule molecule NN cord-262511-96xp1v0r 68 4 MyD88 MyD88 NNS cord-262511-96xp1v0r 68 5 , , , cord-262511-96xp1v0r 68 6 which which WDT cord-262511-96xp1v0r 68 7 transduces transduce VBZ cord-262511-96xp1v0r 68 8 a a DT cord-262511-96xp1v0r 68 9 signal signal NN cord-262511-96xp1v0r 68 10 from from IN cord-262511-96xp1v0r 68 11 TLR TLR NNP cord-262511-96xp1v0r 68 12 , , , cord-262511-96xp1v0r 68 13 causes cause VBZ cord-262511-96xp1v0r 68 14 stabilization stabilization NN cord-262511-96xp1v0r 68 15 of of IN cord-262511-96xp1v0r 68 16 cytokine cytokine NN cord-262511-96xp1v0r 68 17 mRNAs mrnas CD cord-262511-96xp1v0r 68 18 , , , cord-262511-96xp1v0r 69 1 TNF- TNF- NNP cord-262511-96xp1v0r 69 2 ␣ ␣ NN cord-262511-96xp1v0r 69 3 , , , cord-262511-96xp1v0r 69 4 IL-8 IL-8 NNP cord-262511-96xp1v0r 69 5 , , , cord-262511-96xp1v0r 69 6 and and CC cord-262511-96xp1v0r 69 7 IP-10 IP-10 NNP cord-262511-96xp1v0r 69 8 in in IN cord-262511-96xp1v0r 69 9 macrophages macrophage NNS cord-262511-96xp1v0r 69 10 when when WRB cord-262511-96xp1v0r 69 11 stimulated stimulate VBN cord-262511-96xp1v0r 69 12 by by IN cord-262511-96xp1v0r 69 13 IFN- IFN- NNP cord-262511-96xp1v0r 69 14 ␥ ␥ NNP cord-262511-96xp1v0r 69 15 [ [ -LRB- cord-262511-96xp1v0r 69 16 29 29 CD cord-262511-96xp1v0r 69 17 ] ] -RRB- cord-262511-96xp1v0r 69 18 . . . cord-262511-96xp1v0r 70 1 MyD88 myd88 JJ cord-262511-96xp1v0r 70 2 bridges bridge NNS cord-262511-96xp1v0r 71 1 IFN- IFN- NNP cord-262511-96xp1v0r 71 2 ␥ ␥ CD cord-262511-96xp1v0r 71 3 receptor receptor NN cord-262511-96xp1v0r 71 4 1 1 CD cord-262511-96xp1v0r 71 5 and and CC cord-262511-96xp1v0r 71 6 mixed mixed JJ cord-262511-96xp1v0r 71 7 linkage linkage NN cord-262511-96xp1v0r 71 8 kinase kinase NN cord-262511-96xp1v0r 71 9 3 3 CD cord-262511-96xp1v0r 71 10 domains domain NNS cord-262511-96xp1v0r 71 11 , , , cord-262511-96xp1v0r 71 12 leading lead VBG cord-262511-96xp1v0r 71 13 to to IN cord-262511-96xp1v0r 71 14 p38 p38 CD cord-262511-96xp1v0r 71 15 MAPK MAPK NNP cord-262511-96xp1v0r 71 16 activation activation NN cord-262511-96xp1v0r 71 17 [ [ -LRB- cord-262511-96xp1v0r 71 18 31 31 CD cord-262511-96xp1v0r 71 19 ] ] -RRB- cord-262511-96xp1v0r 71 20 . . . cord-262511-96xp1v0r 72 1 LPS LPS NNP cord-262511-96xp1v0r 72 2 - - HYPH cord-262511-96xp1v0r 72 3 induced induce VBN cord-262511-96xp1v0r 72 4 TLR4 TLR4 NNP cord-262511-96xp1v0r 72 5 activation activation NN cord-262511-96xp1v0r 72 6 can can MD cord-262511-96xp1v0r 72 7 increase increase VB cord-262511-96xp1v0r 72 8 formyl formyl NNP cord-262511-96xp1v0r 72 9 peptide peptide NN cord-262511-96xp1v0r 72 10 receptor receptor NN cord-262511-96xp1v0r 72 11 1 1 CD cord-262511-96xp1v0r 72 12 ( ( -LRB- cord-262511-96xp1v0r 72 13 FPR1 FPR1 NNP cord-262511-96xp1v0r 72 14 ) ) -RRB- cord-262511-96xp1v0r 73 1 mRNA mrna NN cord-262511-96xp1v0r 73 2 stability stability NN cord-262511-96xp1v0r 73 3 via via IN cord-262511-96xp1v0r 73 4 a a DT cord-262511-96xp1v0r 73 5 PI-3 pi-3 NN cord-262511-96xp1v0r 74 1 K K NNP cord-262511-96xp1v0r 74 2 pathway pathway NN cord-262511-96xp1v0r 74 3 in in IN cord-262511-96xp1v0r 74 4 phagocytic phagocytic JJ cord-262511-96xp1v0r 74 5 leukocytes leukocyte NNS cord-262511-96xp1v0r 74 6 such such JJ cord-262511-96xp1v0r 74 7 as as IN cord-262511-96xp1v0r 74 8 neutrophils neutrophil NNS cord-262511-96xp1v0r 74 9 and and CC cord-262511-96xp1v0r 74 10 monocytes monocyte NNS cord-262511-96xp1v0r 74 11 , , , cord-262511-96xp1v0r 74 12 leading lead VBG cord-262511-96xp1v0r 74 13 to to IN cord-262511-96xp1v0r 74 14 infiltration infiltration NN cord-262511-96xp1v0r 74 15 to to IN cord-262511-96xp1v0r 74 16 sites site NNS cord-262511-96xp1v0r 74 17 where where WRB cord-262511-96xp1v0r 74 18 the the DT cord-262511-96xp1v0r 74 19 invading invade VBG cord-262511-96xp1v0r 74 20 bacteria bacteria NNS cord-262511-96xp1v0r 74 21 possess possess VBP cord-262511-96xp1v0r 74 22 the the DT cord-262511-96xp1v0r 74 23 formyl formyl NNP cord-262511-96xp1v0r 74 24 peptide peptide NN cord-262511-96xp1v0r 74 25 ligands ligand NNS cord-262511-96xp1v0r 74 26 [ [ -LRB- cord-262511-96xp1v0r 74 27 39 39 CD cord-262511-96xp1v0r 74 28 , , , cord-262511-96xp1v0r 74 29 40 40 CD cord-262511-96xp1v0r 74 30 ] ] -RRB- cord-262511-96xp1v0r 74 31 . . . cord-262511-96xp1v0r 75 1 Thus thus RB cord-262511-96xp1v0r 75 2 , , , cord-262511-96xp1v0r 75 3 TLR4 TLR4 NNP cord-262511-96xp1v0r 75 4 activation activation NN cord-262511-96xp1v0r 75 5 encompasses encompass VBZ cord-262511-96xp1v0r 75 6 several several JJ cord-262511-96xp1v0r 75 7 post post JJ cord-262511-96xp1v0r 75 8 - - JJ cord-262511-96xp1v0r 75 9 transcriptional transcriptional JJ cord-262511-96xp1v0r 75 10 , , , cord-262511-96xp1v0r 75 11 positive positive JJ cord-262511-96xp1v0r 75 12 regulatory regulatory JJ cord-262511-96xp1v0r 75 13 events event NNS cord-262511-96xp1v0r 75 14 , , , cord-262511-96xp1v0r 75 15 which which WDT cord-262511-96xp1v0r 75 16 lead lead VBP cord-262511-96xp1v0r 75 17 to to IN cord-262511-96xp1v0r 75 18 amplification amplification NN cord-262511-96xp1v0r 75 19 of of IN cord-262511-96xp1v0r 75 20 LPSinduced lpsinduced JJ cord-262511-96xp1v0r 75 21 signaling signaling NN cord-262511-96xp1v0r 75 22 and and CC cord-262511-96xp1v0r 75 23 ultimately ultimately RB cord-262511-96xp1v0r 75 24 , , , cord-262511-96xp1v0r 75 25 production production NN cord-262511-96xp1v0r 75 26 of of IN cord-262511-96xp1v0r 75 27 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 75 28 cytokines cytokine NNS cord-262511-96xp1v0r 75 29 ( ( -LRB- cord-262511-96xp1v0r 75 30 Fig Fig NNP cord-262511-96xp1v0r 75 31 . . . cord-262511-96xp1v0r 75 32 1 1 CD cord-262511-96xp1v0r 75 33 ) ) -RRB- cord-262511-96xp1v0r 75 34 . . . cord-262511-96xp1v0r 76 1 These these DT cord-262511-96xp1v0r 76 2 cytokines cytokine NNS cord-262511-96xp1v0r 76 3 and and CC cord-262511-96xp1v0r 76 4 other other JJ cord-262511-96xp1v0r 76 5 mediators mediator NNS cord-262511-96xp1v0r 76 6 , , , cord-262511-96xp1v0r 76 7 including include VBG cord-262511-96xp1v0r 76 8 vascular vascular JJ cord-262511-96xp1v0r 76 9 endothelial endothelial JJ cord-262511-96xp1v0r 76 10 growth growth NN cord-262511-96xp1v0r 76 11 factor factor NN cord-262511-96xp1v0r 76 12 , , , cord-262511-96xp1v0r 76 13 the the DT cord-262511-96xp1v0r 76 14 solute solute NN cord-262511-96xp1v0r 76 15 carrier carrier NN cord-262511-96xp1v0r 76 16 family family NN cord-262511-96xp1v0r 76 17 11 11 CD cord-262511-96xp1v0r 76 18 member member NN cord-262511-96xp1v0r 76 19 1 1 CD cord-262511-96xp1v0r 76 20 , , , cord-262511-96xp1v0r 76 21 and and CC cord-262511-96xp1v0r 76 22 NO no UH cord-262511-96xp1v0r 76 23 , , , cord-262511-96xp1v0r 76 24 can can MD cord-262511-96xp1v0r 76 25 be be VB cord-262511-96xp1v0r 76 26 up up RB cord-262511-96xp1v0r 76 27 - - HYPH cord-262511-96xp1v0r 76 28 regulated regulate VBN cord-262511-96xp1v0r 76 29 at at IN cord-262511-96xp1v0r 76 30 the the DT cord-262511-96xp1v0r 76 31 level level NN cord-262511-96xp1v0r 76 32 of of IN cord-262511-96xp1v0r 76 33 mRNA mrna NN cord-262511-96xp1v0r 76 34 stability stability NN cord-262511-96xp1v0r 76 35 in in IN cord-262511-96xp1v0r 76 36 LPS LPS NNP cord-262511-96xp1v0r 76 37 - - HYPH cord-262511-96xp1v0r 76 38 stimulated stimulate VBN cord-262511-96xp1v0r 76 39 , , , cord-262511-96xp1v0r 76 40 monocytic monocytic JJ cord-262511-96xp1v0r 76 41 cells cell NNS cord-262511-96xp1v0r 76 42 [ [ -LRB- cord-262511-96xp1v0r 76 43 30 30 CD cord-262511-96xp1v0r 76 44 , , , cord-262511-96xp1v0r 76 45 [ [ -LRB- cord-262511-96xp1v0r 76 46 41 41 CD cord-262511-96xp1v0r 76 47 ] ] -RRB- cord-262511-96xp1v0r 77 1 [ [ -LRB- cord-262511-96xp1v0r 77 2 42 42 CD cord-262511-96xp1v0r 77 3 ] ] -RRB- cord-262511-96xp1v0r 77 4 [ [ -LRB- cord-262511-96xp1v0r 77 5 43 43 CD cord-262511-96xp1v0r 77 6 ] ] -RRB- cord-262511-96xp1v0r 77 7 [ [ -LRB- cord-262511-96xp1v0r 77 8 44 44 CD cord-262511-96xp1v0r 77 9 ] ] -RRB- cord-262511-96xp1v0r 77 10 . . . cord-262511-96xp1v0r 78 1 Cytokines cytokine NNS cord-262511-96xp1v0r 78 2 such such JJ cord-262511-96xp1v0r 78 3 as as IN cord-262511-96xp1v0r 78 4 TNF- TNF- NNP cord-262511-96xp1v0r 78 5 ␣ ␣ NNP cord-262511-96xp1v0r 78 6 , , , cord-262511-96xp1v0r 78 7 IL-1 IL-1 NNP cord-262511-96xp1v0r 78 8 , , , cord-262511-96xp1v0r 78 9 IL-6 IL-6 NNP cord-262511-96xp1v0r 78 10 , , , cord-262511-96xp1v0r 78 11 and and CC cord-262511-96xp1v0r 78 12 IL-8 IL-8 NNP cord-262511-96xp1v0r 78 13 not not RB cord-262511-96xp1v0r 78 14 only only RB cord-262511-96xp1v0r 78 15 contribute contribute VBP cord-262511-96xp1v0r 78 16 to to IN cord-262511-96xp1v0r 78 17 effector effector NN cord-262511-96xp1v0r 78 18 mechanisms mechanism NNS cord-262511-96xp1v0r 78 19 of of IN cord-262511-96xp1v0r 78 20 innate innate JJ cord-262511-96xp1v0r 78 21 immunity immunity NN cord-262511-96xp1v0r 78 22 but but CC cord-262511-96xp1v0r 78 23 also also RB cord-262511-96xp1v0r 78 24 help help VB cord-262511-96xp1v0r 78 25 the the DT cord-262511-96xp1v0r 78 26 activation activation NN cord-262511-96xp1v0r 78 27 of of IN cord-262511-96xp1v0r 78 28 adaptive adaptive JJ cord-262511-96xp1v0r 78 29 immunity immunity NN cord-262511-96xp1v0r 78 30 . . . cord-262511-96xp1v0r 79 1 Post post JJ cord-262511-96xp1v0r 79 2 - - JJ cord-262511-96xp1v0r 79 3 transcriptional transcriptional JJ cord-262511-96xp1v0r 79 4 regulation regulation NN cord-262511-96xp1v0r 79 5 of of IN cord-262511-96xp1v0r 79 6 the the DT cord-262511-96xp1v0r 79 7 inflammatory inflammatory JJ cord-262511-96xp1v0r 79 8 response response NN cord-262511-96xp1v0r 79 9 as as IN cord-262511-96xp1v0r 79 10 a a DT cord-262511-96xp1v0r 79 11 result result NN cord-262511-96xp1v0r 79 12 of of IN cord-262511-96xp1v0r 79 13 endotoxin endotoxin NN cord-262511-96xp1v0r 79 14 also also RB cord-262511-96xp1v0r 79 15 offers offer VBZ cord-262511-96xp1v0r 79 16 a a DT cord-262511-96xp1v0r 79 17 negative negative JJ cord-262511-96xp1v0r 79 18 - - HYPH cord-262511-96xp1v0r 79 19 feedback feedback NN cord-262511-96xp1v0r 79 20 control control NN cord-262511-96xp1v0r 79 21 , , , cord-262511-96xp1v0r 79 22 as as IN cord-262511-96xp1v0r 79 23 excessive excessive JJ cord-262511-96xp1v0r 79 24 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 79 25 cytokine cytokine NN cord-262511-96xp1v0r 79 26 production production NN cord-262511-96xp1v0r 79 27 , , , cord-262511-96xp1v0r 79 28 notably notably RB cord-262511-96xp1v0r 79 29 , , , cord-262511-96xp1v0r 79 30 TNF- TNF- NNP cord-262511-96xp1v0r 79 31 ␣ ␣ NNP cord-262511-96xp1v0r 79 32 , , , cord-262511-96xp1v0r 79 33 can can MD cord-262511-96xp1v0r 79 34 lead lead VB cord-262511-96xp1v0r 79 35 to to IN cord-262511-96xp1v0r 79 36 deleterious deleterious JJ cord-262511-96xp1v0r 79 37 , , , cord-262511-96xp1v0r 79 38 local local JJ cord-262511-96xp1v0r 79 39 and and CC cord-262511-96xp1v0r 79 40 systemic systemic JJ cord-262511-96xp1v0r 79 41 effects effect NNS cord-262511-96xp1v0r 79 42 including include VBG cord-262511-96xp1v0r 79 43 septic septic JJ cord-262511-96xp1v0r 79 44 shock shock NN cord-262511-96xp1v0r 79 45 . . . cord-262511-96xp1v0r 80 1 TTP TTP NNP cord-262511-96xp1v0r 80 2 knockout knockout NN cord-262511-96xp1v0r 80 3 mice mouse NNS cord-262511-96xp1v0r 80 4 having have VBG cord-262511-96xp1v0r 80 5 macrophages macrophage NNS cord-262511-96xp1v0r 80 6 and and CC cord-262511-96xp1v0r 80 7 neutrophils neutrophil NNS cord-262511-96xp1v0r 80 8 , , , cord-262511-96xp1v0r 80 9 which which WDT cord-262511-96xp1v0r 80 10 release release VBP cord-262511-96xp1v0r 80 11 higher high JJR cord-262511-96xp1v0r 80 12 levels level NNS cord-262511-96xp1v0r 80 13 of of IN cord-262511-96xp1v0r 80 14 TNF- TNF- NNP cord-262511-96xp1v0r 80 15 ␣ ␣ NN cord-262511-96xp1v0r 80 16 and and CC cord-262511-96xp1v0r 80 17 GM GM NNP cord-262511-96xp1v0r 80 18 - - HYPH cord-262511-96xp1v0r 80 19 CSF CSF NNP cord-262511-96xp1v0r 80 20 , , , cord-262511-96xp1v0r 80 21 display display NN cord-262511-96xp1v0r 80 22 diseases disease NNS cord-262511-96xp1v0r 80 23 associated associate VBN cord-262511-96xp1v0r 80 24 with with IN cord-262511-96xp1v0r 80 25 TNF- TNF- NNP cord-262511-96xp1v0r 80 26 ␣ ␣ NN cord-262511-96xp1v0r 80 27 over over IN cord-262511-96xp1v0r 80 28 secretion secretion NN cord-262511-96xp1v0r 80 29 such such JJ cord-262511-96xp1v0r 80 30 as as IN cord-262511-96xp1v0r 80 31 inflammatory inflammatory JJ cord-262511-96xp1v0r 80 32 arthritis arthritis NN cord-262511-96xp1v0r 80 33 [ [ -LRB- cord-262511-96xp1v0r 80 34 45 45 CD cord-262511-96xp1v0r 80 35 ] ] -RRB- cord-262511-96xp1v0r 80 36 . . . cord-262511-96xp1v0r 81 1 Some some DT cord-262511-96xp1v0r 81 2 of of IN cord-262511-96xp1v0r 81 3 these these DT cord-262511-96xp1v0r 81 4 diseases disease NNS cord-262511-96xp1v0r 81 5 are be VBP cord-262511-96xp1v0r 81 6 similar similar JJ cord-262511-96xp1v0r 81 7 to to IN cord-262511-96xp1v0r 81 8 mice mouse NNS cord-262511-96xp1v0r 81 9 with with IN cord-262511-96xp1v0r 81 10 genetic genetic JJ cord-262511-96xp1v0r 81 11 knockout knockout NN cord-262511-96xp1v0r 81 12 of of IN cord-262511-96xp1v0r 81 13 the the DT cord-262511-96xp1v0r 81 14 TNF- TNF- NNP cord-262511-96xp1v0r 81 15 ␣ ␣ NN cord-262511-96xp1v0r 82 1 ARE are VBP cord-262511-96xp1v0r 82 2 region region NN cord-262511-96xp1v0r 82 3 [ [ -LRB- cord-262511-96xp1v0r 82 4 46 46 CD cord-262511-96xp1v0r 82 5 , , , cord-262511-96xp1v0r 82 6 47 47 CD cord-262511-96xp1v0r 82 7 ] ] -RRB- cord-262511-96xp1v0r 82 8 . . . cord-262511-96xp1v0r 83 1 Like like IN cord-262511-96xp1v0r 83 2 TTP TTP NNP cord-262511-96xp1v0r 83 3 , , , cord-262511-96xp1v0r 83 4 AUF1 AUF1 NNP cord-262511-96xp1v0r 83 5 acts act VBZ cord-262511-96xp1v0r 83 6 as as IN cord-262511-96xp1v0r 83 7 another another DT cord-262511-96xp1v0r 83 8 negative negative JJ cord-262511-96xp1v0r 83 9 - - HYPH cord-262511-96xp1v0r 83 10 feedback feedback NN cord-262511-96xp1v0r 83 11 mediator mediator NN cord-262511-96xp1v0r 83 12 of of IN cord-262511-96xp1v0r 83 13 the the DT cord-262511-96xp1v0r 83 14 innate innate JJ cord-262511-96xp1v0r 83 15 response response NN cord-262511-96xp1v0r 83 16 to to IN cord-262511-96xp1v0r 83 17 endotoxin endotoxin NN cord-262511-96xp1v0r 83 18 ; ; : cord-262511-96xp1v0r 83 19 it -PRON- PRP cord-262511-96xp1v0r 83 20 has have VBZ cord-262511-96xp1v0r 83 21 been be VBN cord-262511-96xp1v0r 83 22 demonstrated demonstrate VBN cord-262511-96xp1v0r 83 23 recently recently RB cord-262511-96xp1v0r 83 24 that that IN cord-262511-96xp1v0r 83 25 LPS LPS NNP cord-262511-96xp1v0r 83 26 challenge challenge NN cord-262511-96xp1v0r 83 27 in in IN cord-262511-96xp1v0r 83 28 AUF1-knockout AUF1-knockout NNP cord-262511-96xp1v0r 83 29 mice mice NN cord-262511-96xp1v0r 83 30 displays display VBZ cord-262511-96xp1v0r 83 31 symptoms symptom NNS cord-262511-96xp1v0r 83 32 of of IN cord-262511-96xp1v0r 83 33 severe severe JJ cord-262511-96xp1v0r 83 34 endotoxic endotoxic JJ cord-262511-96xp1v0r 83 35 shock shock NN cord-262511-96xp1v0r 83 36 as as IN cord-262511-96xp1v0r 83 37 a a DT cord-262511-96xp1v0r 83 38 result result NN cord-262511-96xp1v0r 83 39 of of IN cord-262511-96xp1v0r 83 40 overproduc overproduc NN cord-262511-96xp1v0r 83 41 - - HYPH cord-262511-96xp1v0r 83 42 tion tion NN cord-262511-96xp1v0r 83 43 of of IN cord-262511-96xp1v0r 84 1 TNF- tnf- UH cord-262511-96xp1v0r 84 2 ␣ ␣ NN cord-262511-96xp1v0r 84 3 and and CC cord-262511-96xp1v0r 84 4 IL-1 IL-1 NNP cord-262511-96xp1v0r 84 5 ␤ ␤ NNP cord-262511-96xp1v0r 84 6 [ [ -LRB- cord-262511-96xp1v0r 84 7 48 48 CD cord-262511-96xp1v0r 84 8 ] ] -RRB- cord-262511-96xp1v0r 84 9 . . . cord-262511-96xp1v0r 85 1 This this DT cord-262511-96xp1v0r 85 2 is be VBZ cord-262511-96xp1v0r 85 3 attributed attribute VBN cord-262511-96xp1v0r 85 4 to to IN cord-262511-96xp1v0r 85 5 the the DT cord-262511-96xp1v0r 85 6 inability inability NN cord-262511-96xp1v0r 85 7 to to TO cord-262511-96xp1v0r 85 8 degrade degrade VB cord-262511-96xp1v0r 85 9 the the DT cord-262511-96xp1v0r 85 10 mRNAs mRNAs NNPS cord-262511-96xp1v0r 85 11 efficiently efficiently RB cord-262511-96xp1v0r 85 12 as as IN cord-262511-96xp1v0r 85 13 a a DT cord-262511-96xp1v0r 85 14 result result NN cord-262511-96xp1v0r 85 15 of of IN cord-262511-96xp1v0r 85 16 absence absence NN cord-262511-96xp1v0r 85 17 of of IN cord-262511-96xp1v0r 85 18 AUF1 AUF1 NNP cord-262511-96xp1v0r 85 19 . . . cord-262511-96xp1v0r 86 1 Although although IN cord-262511-96xp1v0r 86 2 HuR hur NN cord-262511-96xp1v0r 86 3 is be VBZ cord-262511-96xp1v0r 86 4 an an DT cord-262511-96xp1v0r 86 5 RNA RNA NNP cord-262511-96xp1v0r 86 6 stabilization stabilization NN cord-262511-96xp1v0r 86 7 protein protein NN cord-262511-96xp1v0r 86 8 , , , cord-262511-96xp1v0r 86 9 it -PRON- PRP cord-262511-96xp1v0r 86 10 can can MD cord-262511-96xp1v0r 86 11 have have VB cord-262511-96xp1v0r 86 12 a a DT cord-262511-96xp1v0r 86 13 negative negative JJ cord-262511-96xp1v0r 86 14 modulatory modulatory JJ cord-262511-96xp1v0r 86 15 function function NN cord-262511-96xp1v0r 86 16 in in IN cord-262511-96xp1v0r 86 17 specific specific JJ cord-262511-96xp1v0r 86 18 situations situation NNS cord-262511-96xp1v0r 86 19 . . . cord-262511-96xp1v0r 87 1 This this DT cord-262511-96xp1v0r 87 2 effect effect NN cord-262511-96xp1v0r 87 3 has have VBZ cord-262511-96xp1v0r 87 4 been be VBN cord-262511-96xp1v0r 87 5 shown show VBN cord-262511-96xp1v0r 87 6 to to TO cord-262511-96xp1v0r 87 7 suppress suppress VB cord-262511-96xp1v0r 87 8 specific specific JJ cord-262511-96xp1v0r 87 9 , , , cord-262511-96xp1v0r 87 10 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 87 11 mRNA mrna NN cord-262511-96xp1v0r 87 12 targets target NNS cord-262511-96xp1v0r 87 13 such such JJ cord-262511-96xp1v0r 87 14 as as IN cord-262511-96xp1v0r 87 15 TNF- TNF- NNP cord-262511-96xp1v0r 87 16 ␣ ␣ NNP cord-262511-96xp1v0r 87 17 and and CC cord-262511-96xp1v0r 87 18 COX-2 COX-2 NNP cord-262511-96xp1v0r 87 19 , , , cord-262511-96xp1v0r 87 20 using use VBG cord-262511-96xp1v0r 87 21 in in IN cord-262511-96xp1v0r 87 22 vivo vivo NN cord-262511-96xp1v0r 87 23 models model NNS cord-262511-96xp1v0r 87 24 with with IN cord-262511-96xp1v0r 87 25 conditional conditional JJ cord-262511-96xp1v0r 87 26 overexpression overexpression NN cord-262511-96xp1v0r 87 27 in in IN cord-262511-96xp1v0r 87 28 macrophage macrophage NN cord-262511-96xp1v0r 87 29 subpopulations subpopulation NNS cord-262511-96xp1v0r 87 30 [ [ -LRB- cord-262511-96xp1v0r 87 31 49 49 CD cord-262511-96xp1v0r 87 32 ] ] -RRB- cord-262511-96xp1v0r 87 33 . . . cord-262511-96xp1v0r 88 1 These these DT cord-262511-96xp1v0r 88 2 three three CD cord-262511-96xp1v0r 88 3 animal animal NN cord-262511-96xp1v0r 88 4 models model NNS cord-262511-96xp1v0r 88 5 of of IN cord-262511-96xp1v0r 88 6 TTP TTP NNP cord-262511-96xp1v0r 88 7 , , , cord-262511-96xp1v0r 88 8 AUF1 AUF1 NNP cord-262511-96xp1v0r 88 9 , , , cord-262511-96xp1v0r 88 10 and and CC cord-262511-96xp1v0r 88 11 HuR hur NN cord-262511-96xp1v0r 88 12 offer offer VBP cord-262511-96xp1v0r 88 13 direct direct JJ cord-262511-96xp1v0r 88 14 in in IN cord-262511-96xp1v0r 88 15 vivo vivo NN cord-262511-96xp1v0r 88 16 evidence evidence NN cord-262511-96xp1v0r 88 17 for for IN cord-262511-96xp1v0r 88 18 the the DT cord-262511-96xp1v0r 88 19 role role NN cord-262511-96xp1v0r 88 20 of of IN cord-262511-96xp1v0r 88 21 posttranscriptional posttranscriptional JJ cord-262511-96xp1v0r 88 22 control control NN cord-262511-96xp1v0r 88 23 in in IN cord-262511-96xp1v0r 88 24 innate innate JJ cord-262511-96xp1v0r 88 25 immunity immunity NN cord-262511-96xp1v0r 88 26 . . . cord-262511-96xp1v0r 89 1 In in IN cord-262511-96xp1v0r 89 2 addition addition NN cord-262511-96xp1v0r 89 3 to to IN cord-262511-96xp1v0r 89 4 LPS LPS NNP cord-262511-96xp1v0r 89 5 , , , cord-262511-96xp1v0r 89 6 another another DT cord-262511-96xp1v0r 89 7 bacterial bacterial JJ cord-262511-96xp1v0r 89 8 component component NN cord-262511-96xp1v0r 89 9 that that WDT cord-262511-96xp1v0r 89 10 is be VBZ cord-262511-96xp1v0r 89 11 an an DT cord-262511-96xp1v0r 89 12 important important JJ cord-262511-96xp1v0r 89 13 stimulus stimulus NN cord-262511-96xp1v0r 89 14 of of IN cord-262511-96xp1v0r 89 15 innate innate JJ cord-262511-96xp1v0r 89 16 immunity immunity NN cord-262511-96xp1v0r 89 17 is be VBZ cord-262511-96xp1v0r 89 18 the the DT cord-262511-96xp1v0r 89 19 unmethylated unmethylate VBN cord-262511-96xp1v0r 89 20 CpG CpG NNP cord-262511-96xp1v0r 89 21 DNA DNA NNP cord-262511-96xp1v0r 89 22 . . . cord-262511-96xp1v0r 90 1 It -PRON- PRP cord-262511-96xp1v0r 90 2 binds bind VBZ cord-262511-96xp1v0r 90 3 TLR9 TLR9 NNP cord-262511-96xp1v0r 90 4 on on IN cord-262511-96xp1v0r 90 5 DC DC NNP cord-262511-96xp1v0r 90 6 , , , cord-262511-96xp1v0r 90 7 neutrophils neutrophil NNS cord-262511-96xp1v0r 90 8 , , , cord-262511-96xp1v0r 90 9 monocytes monocyte NNS cord-262511-96xp1v0r 90 10 , , , cord-262511-96xp1v0r 90 11 and and CC cord-262511-96xp1v0r 90 12 also also RB cord-262511-96xp1v0r 90 13 , , , cord-262511-96xp1v0r 90 14 in in IN cord-262511-96xp1v0r 90 15 airway airway NN cord-262511-96xp1v0r 90 16 epithelia epithelium NNS cord-262511-96xp1v0r 90 17 cells cell NNS cord-262511-96xp1v0r 90 18 triggering trigger VBG cord-262511-96xp1v0r 90 19 a a DT cord-262511-96xp1v0r 90 20 signal signal NN cord-262511-96xp1v0r 90 21 transduction transduction NN cord-262511-96xp1v0r 90 22 cascade cascade VB cord-262511-96xp1v0r 90 23 similar similar JJ cord-262511-96xp1v0r 90 24 to to IN cord-262511-96xp1v0r 90 25 those those DT cord-262511-96xp1v0r 90 26 in in IN cord-262511-96xp1v0r 90 27 response response NN cord-262511-96xp1v0r 90 28 to to IN cord-262511-96xp1v0r 90 29 LPS LPS NNP cord-262511-96xp1v0r 90 30 [ [ -LRB- cord-262511-96xp1v0r 90 31 50 50 CD cord-262511-96xp1v0r 90 32 -52 -52 NNS cord-262511-96xp1v0r 90 33 ] ] -RRB- cord-262511-96xp1v0r 90 34 . . . cord-262511-96xp1v0r 91 1 Cytokines cytokine NNS cord-262511-96xp1v0r 91 2 such such JJ cord-262511-96xp1v0r 91 3 as as IN cord-262511-96xp1v0r 91 4 IL-1 IL-1 NNP cord-262511-96xp1v0r 91 5 ␣ ␣ NNP cord-262511-96xp1v0r 92 1 and and CC cord-262511-96xp1v0r 92 2 TNF- TNF- NNP cord-262511-96xp1v0r 92 3 ␣ ␣ NNP cord-262511-96xp1v0r 92 4 synergize synergize VBP cord-262511-96xp1v0r 92 5 with with IN cord-262511-96xp1v0r 92 6 CpG CpG NNP cord-262511-96xp1v0r 92 7 DNA DNA NNP cord-262511-96xp1v0r 92 8 to to TO cord-262511-96xp1v0r 92 9 induce induce VB cord-262511-96xp1v0r 92 10 IL-8 IL-8 NNP cord-262511-96xp1v0r 92 11 production production NN cord-262511-96xp1v0r 92 12 in in IN cord-262511-96xp1v0r 92 13 airway airway NN cord-262511-96xp1v0r 92 14 epithelia epithelium NNS cord-262511-96xp1v0r 92 15 , , , cord-262511-96xp1v0r 92 16 mainly mainly RB cord-262511-96xp1v0r 92 17 by by IN cord-262511-96xp1v0r 92 18 p38 p38 CD cord-262511-96xp1v0r 92 19 MAPK MAPK NNP cord-262511-96xp1v0r 92 20 activation activation NN cord-262511-96xp1v0r 92 21 and and CC cord-262511-96xp1v0r 92 22 stability stability NN cord-262511-96xp1v0r 92 23 of of IN cord-262511-96xp1v0r 92 24 IL-8 IL-8 NNP cord-262511-96xp1v0r 92 25 mRNA mrna NN cord-262511-96xp1v0r 92 26 [ [ -LRB- cord-262511-96xp1v0r 92 27 51 51 CD cord-262511-96xp1v0r 92 28 ] ] -RRB- cord-262511-96xp1v0r 92 29 . . . cord-262511-96xp1v0r 93 1 CpG CpG NNP cord-262511-96xp1v0r 93 2 DNA DNA NNP cord-262511-96xp1v0r 93 3 can can MD cord-262511-96xp1v0r 93 4 augment augment VB cord-262511-96xp1v0r 93 5 DC DC NNP cord-262511-96xp1v0r 93 6 function function NN cord-262511-96xp1v0r 93 7 and and CC cord-262511-96xp1v0r 93 8 maturation maturation NN cord-262511-96xp1v0r 93 9 using use VBG cord-262511-96xp1v0r 93 10 post post JJ cord-262511-96xp1v0r 93 11 - - JJ cord-262511-96xp1v0r 93 12 transcriptional transcriptional JJ cord-262511-96xp1v0r 93 13 mechanisms mechanism NNS cord-262511-96xp1v0r 93 14 . . . cord-262511-96xp1v0r 94 1 For for IN cord-262511-96xp1v0r 94 2 example example NN cord-262511-96xp1v0r 94 3 , , , cord-262511-96xp1v0r 94 4 CpG CpG NNP cord-262511-96xp1v0r 94 5 DNA DNA NNP cord-262511-96xp1v0r 94 6 increases increase VBZ cord-262511-96xp1v0r 94 7 MHC MHC NNP cord-262511-96xp1v0r 94 8 I -PRON- PRP cord-262511-96xp1v0r 94 9 mRNA mrna NN cord-262511-96xp1v0r 94 10 stability stability NN cord-262511-96xp1v0r 94 11 in in IN cord-262511-96xp1v0r 94 12 DC DC NNP cord-262511-96xp1v0r 94 13 by by IN cord-262511-96xp1v0r 94 14 an an DT cord-262511-96xp1v0r 94 15 IFN- IFN- NNP cord-262511-96xp1v0r 94 16 ␣ ␣ NN cord-262511-96xp1v0r 94 17 / / SYM cord-262511-96xp1v0r 94 18 ␤ ␤ IN cord-262511-96xp1v0r 94 19 -dependent -dependent JJ cord-262511-96xp1v0r 94 20 process process NN cord-262511-96xp1v0r 94 21 [ [ -LRB- cord-262511-96xp1v0r 94 22 52 52 CD cord-262511-96xp1v0r 94 23 ] ] -RRB- cord-262511-96xp1v0r 94 24 . . . cord-262511-96xp1v0r 95 1 HuR HuR NNP cord-262511-96xp1v0r 95 2 binds bind VBZ cord-262511-96xp1v0r 95 3 to to IN cord-262511-96xp1v0r 95 4 a a DT cord-262511-96xp1v0r 95 5 defined define VBN cord-262511-96xp1v0r 95 6 , , , cord-262511-96xp1v0r 95 7 secondary secondary JJ cord-262511-96xp1v0r 95 8 RNA RNA NNP cord-262511-96xp1v0r 95 9 element element NN cord-262511-96xp1v0r 95 10 in in IN cord-262511-96xp1v0r 95 11 the the DT cord-262511-96xp1v0r 95 12 DC DC NNP cord-262511-96xp1v0r 95 13 mRNA mrna NN cord-262511-96xp1v0r 95 14 of of IN cord-262511-96xp1v0r 95 15 CD83 CD83 NNP cord-262511-96xp1v0r 95 16 and and CC cord-262511-96xp1v0r 95 17 increases increase VBZ cord-262511-96xp1v0r 95 18 its -PRON- PRP$ cord-262511-96xp1v0r 95 19 protein protein NN cord-262511-96xp1v0r 95 20 expression expression NN cord-262511-96xp1v0r 95 21 [ [ -LRB- cord-262511-96xp1v0r 95 22 53 53 CD cord-262511-96xp1v0r 95 23 ] ] -RRB- cord-262511-96xp1v0r 95 24 . . . cord-262511-96xp1v0r 96 1 However however RB cord-262511-96xp1v0r 96 2 , , , cord-262511-96xp1v0r 96 3 this this DT cord-262511-96xp1v0r 96 4 effect effect NN cord-262511-96xp1v0r 96 5 does do VBZ cord-262511-96xp1v0r 96 6 not not RB cord-262511-96xp1v0r 96 7 involve involve VB cord-262511-96xp1v0r 96 8 mRNA mRNA NNP cord-262511-96xp1v0r 96 9 stabilization stabilization NN cord-262511-96xp1v0r 96 10 , , , cord-262511-96xp1v0r 96 11 probably probably RB cord-262511-96xp1v0r 96 12 as as IN cord-262511-96xp1v0r 96 13 a a DT cord-262511-96xp1v0r 96 14 result result NN cord-262511-96xp1v0r 96 15 of of IN cord-262511-96xp1v0r 96 16 lack lack NN cord-262511-96xp1v0r 96 17 of of IN cord-262511-96xp1v0r 96 18 AREs are NNS cord-262511-96xp1v0r 96 19 in in IN cord-262511-96xp1v0r 96 20 CD83 CD83 NNP cord-262511-96xp1v0r 96 21 3ЈUTR 3ЈUTR NNP cord-262511-96xp1v0r 96 22 [ [ -LRB- cord-262511-96xp1v0r 96 23 1 1 CD cord-262511-96xp1v0r 96 24 ] ] -RRB- cord-262511-96xp1v0r 96 25 but but CC cord-262511-96xp1v0r 96 26 most most RBS cord-262511-96xp1v0r 96 27 likely likely JJ cord-262511-96xp1v0r 96 28 because because IN cord-262511-96xp1v0r 96 29 of of IN cord-262511-96xp1v0r 96 30 enhanced enhance VBN cord-262511-96xp1v0r 96 31 , , , cord-262511-96xp1v0r 96 32 chromosome chromosome NN cord-262511-96xp1v0r 96 33 region region NN cord-262511-96xp1v0r 96 34 maintenance maintenance NN cord-262511-96xp1v0r 96 35 1-mediated 1-mediated CD cord-262511-96xp1v0r 96 36 translocation translocation NN cord-262511-96xp1v0r 96 37 of of IN cord-262511-96xp1v0r 96 38 CD83 CD83 NNP cord-262511-96xp1v0r 96 39 mRNA mRNA NNP cord-262511-96xp1v0r 96 40 to to IN cord-262511-96xp1v0r 96 41 the the DT cord-262511-96xp1v0r 96 42 cytoplasm cytoplasm NN cord-262511-96xp1v0r 96 43 by by IN cord-262511-96xp1v0r 96 44 HuR HuR NNP cord-262511-96xp1v0r 96 45 [ [ -LRB- cord-262511-96xp1v0r 96 46 53 53 CD cord-262511-96xp1v0r 96 47 ] ] -RRB- cord-262511-96xp1v0r 96 48 . . . cord-262511-96xp1v0r 97 1 Mature mature JJ cord-262511-96xp1v0r 97 2 DC DC NNP cord-262511-96xp1v0r 97 3 , , , cord-262511-96xp1v0r 97 4 which which WDT cord-262511-96xp1v0r 97 5 express express VBP cord-262511-96xp1v0r 97 6 CD83 CD83 NNP cord-262511-96xp1v0r 97 7 , , , cord-262511-96xp1v0r 97 8 are be VBP cord-262511-96xp1v0r 97 9 efficient efficient JJ cord-262511-96xp1v0r 97 10 in in IN cord-262511-96xp1v0r 97 11 the the DT cord-262511-96xp1v0r 97 12 stimulation stimulation NN cord-262511-96xp1v0r 97 13 of of IN cord-262511-96xp1v0r 97 14 naive naive JJ cord-262511-96xp1v0r 97 15 CD4 CD4 NNP cord-262511-96xp1v0r 97 16 ϩ ϩ NNP cord-262511-96xp1v0r 97 17 and and CC cord-262511-96xp1v0r 97 18 CD8 CD8 NNP cord-262511-96xp1v0r 97 19 ϩ ϩ NNP cord-262511-96xp1v0r 97 20 T T NNP cord-262511-96xp1v0r 97 21 cells cell NNS cord-262511-96xp1v0r 97 22 . . . cord-262511-96xp1v0r 98 1 So so RB cord-262511-96xp1v0r 98 2 , , , cord-262511-96xp1v0r 98 3 these these DT cord-262511-96xp1v0r 98 4 posttranscriptional posttranscriptional JJ cord-262511-96xp1v0r 98 5 , , , cord-262511-96xp1v0r 98 6 regulation regulation NN cord-262511-96xp1v0r 98 7 events event NNS cord-262511-96xp1v0r 98 8 contribute contribute VBP cord-262511-96xp1v0r 98 9 to to IN cord-262511-96xp1v0r 98 10 the the DT cord-262511-96xp1v0r 98 11 efficient efficient JJ cord-262511-96xp1v0r 98 12 maturation maturation NN cord-262511-96xp1v0r 98 13 of of IN cord-262511-96xp1v0r 98 14 DC DC NNP cord-262511-96xp1v0r 98 15 - - HYPH cord-262511-96xp1v0r 98 16 cells cell NNS cord-262511-96xp1v0r 98 17 , , , cord-262511-96xp1v0r 98 18 which which WDT cord-262511-96xp1v0r 98 19 are be VBP cord-262511-96xp1v0r 98 20 important important JJ cord-262511-96xp1v0r 98 21 APCs apc NNS cord-262511-96xp1v0r 98 22 - - : cord-262511-96xp1v0r 98 23 and and CC cord-262511-96xp1v0r 98 24 further further RB cord-262511-96xp1v0r 98 25 , , , cord-262511-96xp1v0r 98 26 aid aid NN cord-262511-96xp1v0r 98 27 bridging bridge VBG cord-262511-96xp1v0r 98 28 innate innate JJ cord-262511-96xp1v0r 98 29 immunity immunity NN cord-262511-96xp1v0r 98 30 to to IN cord-262511-96xp1v0r 98 31 adaptive adaptive JJ cord-262511-96xp1v0r 98 32 immunity immunity NN cord-262511-96xp1v0r 98 33 . . . cord-262511-96xp1v0r 99 1 Different different JJ cord-262511-96xp1v0r 99 2 viruses virus NNS cord-262511-96xp1v0r 99 3 code code VBP cord-262511-96xp1v0r 99 4 for for IN cord-262511-96xp1v0r 99 5 different different JJ cord-262511-96xp1v0r 99 6 viral viral JJ cord-262511-96xp1v0r 99 7 proteins protein NNS cord-262511-96xp1v0r 99 8 , , , cord-262511-96xp1v0r 99 9 which which WDT cord-262511-96xp1v0r 99 10 can can MD cord-262511-96xp1v0r 99 11 control control VB cord-262511-96xp1v0r 99 12 the the DT cord-262511-96xp1v0r 99 13 cell cell NN cord-262511-96xp1v0r 99 14 's 's POS cord-262511-96xp1v0r 99 15 machinery machinery NN cord-262511-96xp1v0r 99 16 for for IN cord-262511-96xp1v0r 99 17 their -PRON- PRP$ cord-262511-96xp1v0r 99 18 growth growth NN cord-262511-96xp1v0r 99 19 or or CC cord-262511-96xp1v0r 99 20 to to TO cord-262511-96xp1v0r 99 21 evade evade VB cord-262511-96xp1v0r 99 22 immune immune JJ cord-262511-96xp1v0r 99 23 cells cell NNS cord-262511-96xp1v0r 99 24 [ [ -LRB- cord-262511-96xp1v0r 99 25 54 54 CD cord-262511-96xp1v0r 99 26 ] ] -RRB- cord-262511-96xp1v0r 99 27 . . . cord-262511-96xp1v0r 100 1 Viruses virus NNS cord-262511-96xp1v0r 100 2 can can MD cord-262511-96xp1v0r 100 3 stabilize stabilize VB cord-262511-96xp1v0r 100 4 mRNAs mrnas CD cord-262511-96xp1v0r 100 5 of of IN cord-262511-96xp1v0r 100 6 gene gene NN cord-262511-96xp1v0r 100 7 products product NNS cord-262511-96xp1v0r 100 8 that that WDT cord-262511-96xp1v0r 100 9 are be VBP cord-262511-96xp1v0r 100 10 essential essential JJ cord-262511-96xp1v0r 100 11 to to IN cord-262511-96xp1v0r 100 12 the the DT cord-262511-96xp1v0r 100 13 virus virus NN cord-262511-96xp1v0r 100 14 life life NN cord-262511-96xp1v0r 100 15 cycle cycle NN cord-262511-96xp1v0r 100 16 . . . cord-262511-96xp1v0r 101 1 HSV HSV NNP cord-262511-96xp1v0r 101 2 infection infection NN cord-262511-96xp1v0r 101 3 can can MD cord-262511-96xp1v0r 101 4 lead lead VB cord-262511-96xp1v0r 101 5 to to IN cord-262511-96xp1v0r 101 6 stabilization stabilization NN cord-262511-96xp1v0r 101 7 of of IN cord-262511-96xp1v0r 101 8 the the DT cord-262511-96xp1v0r 101 9 ARE ARE NNP cord-262511-96xp1v0r 101 10 - - HYPH cord-262511-96xp1v0r 101 11 mRNA mrna NN cord-262511-96xp1v0r 101 12 , , , cord-262511-96xp1v0r 101 13 termed term VBD cord-262511-96xp1v0r 101 14 immediate immediate JJ cord-262511-96xp1v0r 101 15 early early JJ cord-262511-96xp1v0r 101 16 response response NN cord-262511-96xp1v0r 101 17 3 3 CD cord-262511-96xp1v0r 101 18 ( ( -LRB- cord-262511-96xp1v0r 101 19 IEX-1 IEX-1 NNP cord-262511-96xp1v0r 101 20 ) ) -RRB- cord-262511-96xp1v0r 101 21 , , , cord-262511-96xp1v0r 101 22 probably probably RB cord-262511-96xp1v0r 101 23 by by IN cord-262511-96xp1v0r 101 24 means mean NNS cord-262511-96xp1v0r 101 25 of of IN cord-262511-96xp1v0r 101 26 its -PRON- PRP$ cord-262511-96xp1v0r 101 27 transregulatory transregulatory NN cord-262511-96xp1v0r 101 28 protein protein NN cord-262511-96xp1v0r 101 29 ICP27 ICP27 NNP cord-262511-96xp1v0r 101 30 , , , cord-262511-96xp1v0r 101 31 which which WDT cord-262511-96xp1v0r 101 32 is be VBZ cord-262511-96xp1v0r 101 33 essential essential JJ cord-262511-96xp1v0r 101 34 in in IN cord-262511-96xp1v0r 101 35 HSV HSV NNP cord-262511-96xp1v0r 101 36 early early JJ cord-262511-96xp1v0r 101 37 gene gene NN cord-262511-96xp1v0r 101 38 expression expression NN cord-262511-96xp1v0r 101 39 [ [ -LRB- cord-262511-96xp1v0r 101 40 55 55 CD cord-262511-96xp1v0r 101 41 , , , cord-262511-96xp1v0r 101 42 56 56 CD cord-262511-96xp1v0r 101 43 ] ] -RRB- cord-262511-96xp1v0r 101 44 . . . cord-262511-96xp1v0r 102 1 The the DT cord-262511-96xp1v0r 102 2 latent latent JJ cord-262511-96xp1v0r 102 3 membrane membrane NN cord-262511-96xp1v0r 102 4 protein protein NN cord-262511-96xp1v0r 102 5 1 1 CD cord-262511-96xp1v0r 102 6 ( ( -LRB- cord-262511-96xp1v0r 102 7 LMP1 LMP1 NNP cord-262511-96xp1v0r 102 8 ) ) -RRB- cord-262511-96xp1v0r 102 9 of of IN cord-262511-96xp1v0r 102 10 EBV EBV NNP cord-262511-96xp1v0r 102 11 is be VBZ cord-262511-96xp1v0r 102 12 a a DT cord-262511-96xp1v0r 102 13 major major JJ cord-262511-96xp1v0r 102 14 player player NN cord-262511-96xp1v0r 102 15 in in IN cord-262511-96xp1v0r 102 16 the the DT cord-262511-96xp1v0r 102 17 induction induction NN cord-262511-96xp1v0r 102 18 of of IN cord-262511-96xp1v0r 102 19 cytokines cytokine NNS cord-262511-96xp1v0r 102 20 , , , cord-262511-96xp1v0r 102 21 which which WDT cord-262511-96xp1v0r 102 22 in in IN cord-262511-96xp1v0r 102 23 turn turn NN cord-262511-96xp1v0r 102 24 , , , cord-262511-96xp1v0r 102 25 support support VB cord-262511-96xp1v0r 102 26 the the DT cord-262511-96xp1v0r 102 27 growth growth NN cord-262511-96xp1v0r 102 28 and and CC cord-262511-96xp1v0r 102 29 survival survival NN cord-262511-96xp1v0r 102 30 of of IN cord-262511-96xp1v0r 102 31 the the DT cord-262511-96xp1v0r 102 32 EBV EBV NNP cord-262511-96xp1v0r 102 33 - - HYPH cord-262511-96xp1v0r 102 34 infected infect VBN cord-262511-96xp1v0r 102 35 B b NN cord-262511-96xp1v0r 102 36 cells cell NNS cord-262511-96xp1v0r 102 37 . . . cord-262511-96xp1v0r 103 1 LMP1 LMP1 NNP cord-262511-96xp1v0r 103 2 activates activate VBZ cord-262511-96xp1v0r 103 3 the the DT cord-262511-96xp1v0r 103 4 p38 p38 CD cord-262511-96xp1v0r 103 5 MAPK MAPK NNP cord-262511-96xp1v0r 103 6 pathway pathway NN cord-262511-96xp1v0r 103 7 and and CC cord-262511-96xp1v0r 103 8 stabilizes stabilize VBZ cord-262511-96xp1v0r 103 9 IP-10 IP-10 NNP cord-262511-96xp1v0r 103 10 [ [ -LRB- cord-262511-96xp1v0r 103 11 57 57 CD cord-262511-96xp1v0r 103 12 ] ] -RRB- cord-262511-96xp1v0r 103 13 . . . cord-262511-96xp1v0r 104 1 The the DT cord-262511-96xp1v0r 104 2 Kaposi Kaposi NNP cord-262511-96xp1v0r 104 3 sarcoma sarcoma NN cord-262511-96xp1v0r 104 4 ( ( -LRB- cord-262511-96xp1v0r 104 5 KS KS NNP cord-262511-96xp1v0r 104 6 ) ) -RRB- cord-262511-96xp1v0r 104 7 herpes herpe NNS cord-262511-96xp1v0r 104 8 virus virus NN cord-262511-96xp1v0r 104 9 ( ( -LRB- cord-262511-96xp1v0r 104 10 KSHV KSHV NNP cord-262511-96xp1v0r 104 11 or or CC cord-262511-96xp1v0r 104 12 HSV-8 HSV-8 NNP cord-262511-96xp1v0r 104 13 ) ) -RRB- cord-262511-96xp1v0r 104 14 , , , cord-262511-96xp1v0r 104 15 which which WDT cord-262511-96xp1v0r 104 16 causes cause VBZ cord-262511-96xp1v0r 104 17 angioproliferative angioproliferative JJ cord-262511-96xp1v0r 104 18 regions region NNS cord-262511-96xp1v0r 104 19 in in IN cord-262511-96xp1v0r 104 20 immunocompromised immunocompromised JJ cord-262511-96xp1v0r 104 21 patients patient NNS cord-262511-96xp1v0r 104 22 such such JJ cord-262511-96xp1v0r 104 23 as as IN cord-262511-96xp1v0r 104 24 AIDS AIDS NNP cord-262511-96xp1v0r 104 25 and and CC cord-262511-96xp1v0r 104 26 transplant transplant NN cord-262511-96xp1v0r 104 27 patients patient NNS cord-262511-96xp1v0r 104 28 , , , cord-262511-96xp1v0r 104 29 promotes promote VBZ cord-262511-96xp1v0r 104 30 the the DT cord-262511-96xp1v0r 104 31 production production NN cord-262511-96xp1v0r 104 32 of of IN cord-262511-96xp1v0r 104 33 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 104 34 cytokines cytokine NNS cord-262511-96xp1v0r 104 35 . . . cord-262511-96xp1v0r 105 1 Using use VBG cord-262511-96xp1v0r 105 2 a a DT cord-262511-96xp1v0r 105 3 twohybrid twohybrid NN cord-262511-96xp1v0r 105 4 system system NN cord-262511-96xp1v0r 105 5 , , , cord-262511-96xp1v0r 105 6 the the DT cord-262511-96xp1v0r 105 7 KSHV KSHV NNP cord-262511-96xp1v0r 105 8 latent latent NN cord-262511-96xp1v0r 105 9 protein protein NN cord-262511-96xp1v0r 105 10 kaposin kaposin NNP cord-262511-96xp1v0r 105 11 B B NNP cord-262511-96xp1v0r 105 12 has have VBZ cord-262511-96xp1v0r 105 13 been be VBN cord-262511-96xp1v0r 105 14 shown show VBN cord-262511-96xp1v0r 105 15 to to TO cord-262511-96xp1v0r 105 16 interact interact VB cord-262511-96xp1v0r 105 17 with with IN cord-262511-96xp1v0r 105 18 the the DT cord-262511-96xp1v0r 105 19 c c NN cord-262511-96xp1v0r 105 20 - - HYPH cord-262511-96xp1v0r 105 21 lobe lobe NN cord-262511-96xp1v0r 105 22 of of IN cord-262511-96xp1v0r 105 23 the the DT cord-262511-96xp1v0r 105 24 activation activation NN cord-262511-96xp1v0r 105 25 domain domain NN cord-262511-96xp1v0r 105 26 of of IN cord-262511-96xp1v0r 105 27 MK2 MK2 NNP cord-262511-96xp1v0r 105 28 and and CC cord-262511-96xp1v0r 105 29 requires require VBZ cord-262511-96xp1v0r 105 30 both both DT cord-262511-96xp1v0r 105 31 of of IN cord-262511-96xp1v0r 105 32 the the DT cord-262511-96xp1v0r 105 33 two two CD cord-262511-96xp1v0r 105 34 proline proline NN cord-262511-96xp1v0r 105 35 - - HYPH cord-262511-96xp1v0r 105 36 rich rich JJ cord-262511-96xp1v0r 105 37 , , , cord-262511-96xp1v0r 105 38 23-amino 23-amino CD cord-262511-96xp1v0r 105 39 acid acid NN cord-262511-96xp1v0r 105 40 direct direct JJ cord-262511-96xp1v0r 105 41 repeats repeat NNS cord-262511-96xp1v0r 105 42 in in IN cord-262511-96xp1v0r 105 43 kaposin kaposin NNP cord-262511-96xp1v0r 105 44 B B NNP cord-262511-96xp1v0r 105 45 [ [ -LRB- cord-262511-96xp1v0r 105 46 58 58 CD cord-262511-96xp1v0r 105 47 , , , cord-262511-96xp1v0r 105 48 59 59 CD cord-262511-96xp1v0r 105 49 ] ] -RRB- cord-262511-96xp1v0r 105 50 . . . cord-262511-96xp1v0r 106 1 As as IN cord-262511-96xp1v0r 106 2 a a DT cord-262511-96xp1v0r 106 3 result result NN cord-262511-96xp1v0r 106 4 , , , cord-262511-96xp1v0r 106 5 MK2 MK2 NNP cord-262511-96xp1v0r 106 6 becomes become VBZ cord-262511-96xp1v0r 106 7 phosphorylated phosphorylate VBN cord-262511-96xp1v0r 106 8 , , , cord-262511-96xp1v0r 106 9 and and CC cord-262511-96xp1v0r 106 10 loss loss NN cord-262511-96xp1v0r 106 11 of of IN cord-262511-96xp1v0r 106 12 destabilization destabilization NN cord-262511-96xp1v0r 106 13 of of IN cord-262511-96xp1v0r 106 14 AU AU NNP cord-262511-96xp1v0r 106 15 - - HYPH cord-262511-96xp1v0r 106 16 rich rich JJ cord-262511-96xp1v0r 106 17 mRNAs mrna NNS cord-262511-96xp1v0r 106 18 such such JJ cord-262511-96xp1v0r 106 19 as as IN cord-262511-96xp1v0r 106 20 GM GM NNP cord-262511-96xp1v0r 106 21 - - HYPH cord-262511-96xp1v0r 106 22 CSF CSF NNP cord-262511-96xp1v0r 106 23 and and CC cord-262511-96xp1v0r 106 24 IL-6 IL-6 NNP cord-262511-96xp1v0r 106 25 occurs occur VBZ cord-262511-96xp1v0r 106 26 [ [ -LRB- cord-262511-96xp1v0r 106 27 58 58 CD cord-262511-96xp1v0r 106 28 ] ] -RRB- cord-262511-96xp1v0r 106 29 . . . cord-262511-96xp1v0r 107 1 IL-6 IL-6 NNP cord-262511-96xp1v0r 107 2 is be VBZ cord-262511-96xp1v0r 107 3 overexpressed overexpresse VBN cord-262511-96xp1v0r 107 4 in in IN cord-262511-96xp1v0r 107 5 KS KS NNP cord-262511-96xp1v0r 107 6 tumors tumor NNS cord-262511-96xp1v0r 107 7 and and CC cord-262511-96xp1v0r 107 8 contributes contribute VBZ cord-262511-96xp1v0r 107 9 to to IN cord-262511-96xp1v0r 107 10 its -PRON- PRP$ cord-262511-96xp1v0r 107 11 pathogenesis pathogenesis NN cord-262511-96xp1v0r 107 12 [ [ -LRB- cord-262511-96xp1v0r 107 13 60 60 CD cord-262511-96xp1v0r 107 14 ] ] -RRB- cord-262511-96xp1v0r 107 15 . . . cord-262511-96xp1v0r 108 1 Replication replication NN cord-262511-96xp1v0r 108 2 of of IN cord-262511-96xp1v0r 108 3 hepatitis hepatitis NN cord-262511-96xp1v0r 108 4 C c NN cord-262511-96xp1v0r 108 5 virus virus NN cord-262511-96xp1v0r 108 6 ( ( -LRB- cord-262511-96xp1v0r 108 7 HCV HCV NNP cord-262511-96xp1v0r 108 8 ) ) -RRB- cord-262511-96xp1v0r 108 9 in in IN cord-262511-96xp1v0r 108 10 cultured cultured JJ cord-262511-96xp1v0r 108 11 liver liver NN cord-262511-96xp1v0r 108 12 cell cell NN cord-262511-96xp1v0r 108 13 lines line NNS cord-262511-96xp1v0r 108 14 leads lead VBZ cord-262511-96xp1v0r 108 15 to to IN cord-262511-96xp1v0r 108 16 prolongation prolongation NN cord-262511-96xp1v0r 108 17 of of IN cord-262511-96xp1v0r 108 18 the the DT cord-262511-96xp1v0r 108 19 IL-8 IL-8 NNP cord-262511-96xp1v0r 108 20 mRNA mRNA NNP cord-262511-96xp1v0r 108 21 half half JJ cord-262511-96xp1v0r 108 22 - - HYPH cord-262511-96xp1v0r 108 23 life life NN cord-262511-96xp1v0r 108 24 , , , cord-262511-96xp1v0r 108 25 probably probably RB cord-262511-96xp1v0r 108 26 by by IN cord-262511-96xp1v0r 108 27 its -PRON- PRP$ cord-262511-96xp1v0r 108 28 nonstructural nonstructural JJ cord-262511-96xp1v0r 108 29 protein protein NN cord-262511-96xp1v0r 108 30 NS5A NS5A NNP cord-262511-96xp1v0r 108 31 , , , cord-262511-96xp1v0r 108 32 and and CC cord-262511-96xp1v0r 108 33 particularly particularly RB cord-262511-96xp1v0r 108 34 , , , cord-262511-96xp1v0r 108 35 in in IN cord-262511-96xp1v0r 108 36 the the DT cord-262511-96xp1v0r 108 37 presence presence NN cord-262511-96xp1v0r 108 38 of of IN cord-262511-96xp1v0r 108 39 TNF- TNF- NNP cord-262511-96xp1v0r 108 40 ␣ ␣ NNP cord-262511-96xp1v0r 108 41 , , , cord-262511-96xp1v0r 108 42 a a DT cord-262511-96xp1v0r 108 43 potent potent JJ cord-262511-96xp1v0r 108 44 inducer inducer NN cord-262511-96xp1v0r 108 45 of of IN cord-262511-96xp1v0r 108 46 IL-8 IL-8 NNP cord-262511-96xp1v0r 108 47 [ [ -LRB- cord-262511-96xp1v0r 108 48 28 28 CD cord-262511-96xp1v0r 108 49 ] ] -RRB- cord-262511-96xp1v0r 108 50 . . . cord-262511-96xp1v0r 109 1 A a DT cord-262511-96xp1v0r 109 2 possible possible JJ cord-262511-96xp1v0r 109 3 mechanism mechanism NN cord-262511-96xp1v0r 109 4 is be VBZ cord-262511-96xp1v0r 109 5 that that IN cord-262511-96xp1v0r 109 6 HCV HCV NNP cord-262511-96xp1v0r 109 7 , , , cord-262511-96xp1v0r 109 8 in in IN cord-262511-96xp1v0r 109 9 a a DT cord-262511-96xp1v0r 109 10 similar similar JJ cord-262511-96xp1v0r 109 11 manner manner NN cord-262511-96xp1v0r 109 12 to to IN cord-262511-96xp1v0r 109 13 dsRNA dsrna NN cord-262511-96xp1v0r 109 14 , , , cord-262511-96xp1v0r 109 15 which which WDT cord-262511-96xp1v0r 109 16 is be VBZ cord-262511-96xp1v0r 109 17 an an DT cord-262511-96xp1v0r 109 18 intermediate intermediate JJ cord-262511-96xp1v0r 109 19 viral viral JJ cord-262511-96xp1v0r 109 20 product product NN cord-262511-96xp1v0r 109 21 , , , cord-262511-96xp1v0r 109 22 may may MD cord-262511-96xp1v0r 109 23 activate activate VB cord-262511-96xp1v0r 109 24 the the DT cord-262511-96xp1v0r 109 25 retinoic retinoic JJ cord-262511-96xp1v0r 109 26 acid acid NN cord-262511-96xp1v0r 109 27 - - HYPH cord-262511-96xp1v0r 109 28 inducible inducible JJ cord-262511-96xp1v0r 109 29 gene gene NN cord-262511-96xp1v0r 109 30 I i NN cord-262511-96xp1v0r 109 31 ( ( -LRB- cord-262511-96xp1v0r 109 32 RIG rig NN cord-262511-96xp1v0r 109 33 - - : cord-262511-96xp1v0r 109 34 I I NNP cord-262511-96xp1v0r 109 35 ) ) -RRB- cord-262511-96xp1v0r 109 36 pathway pathway NN cord-262511-96xp1v0r 109 37 , , , cord-262511-96xp1v0r 109 38 leading lead VBG cord-262511-96xp1v0r 109 39 to to IN cord-262511-96xp1v0r 109 40 IL-8 IL-8 NNP cord-262511-96xp1v0r 109 41 mRNA mRNA NNP cord-262511-96xp1v0r 109 42 stabilization stabilization NN cord-262511-96xp1v0r 109 43 . . . cord-262511-96xp1v0r 110 1 RIG rig NN cord-262511-96xp1v0r 110 2 - - : cord-262511-96xp1v0r 110 3 I -PRON- PRP cord-262511-96xp1v0r 110 4 along along RP cord-262511-96xp1v0r 110 5 with with IN cord-262511-96xp1v0r 110 6 melanoma melanoma NN cord-262511-96xp1v0r 110 7 differentiation differentiation NN cord-262511-96xp1v0r 110 8 - - HYPH cord-262511-96xp1v0r 110 9 associated associate VBN cord-262511-96xp1v0r 110 10 gene gene NN cord-262511-96xp1v0r 110 11 5 5 CD cord-262511-96xp1v0r 110 12 , , , cord-262511-96xp1v0r 110 13 which which WDT cord-262511-96xp1v0r 110 14 has have VBZ cord-262511-96xp1v0r 110 15 been be VBN cord-262511-96xp1v0r 110 16 a a DT cord-262511-96xp1v0r 110 17 focus focus NN cord-262511-96xp1v0r 110 18 of of IN cord-262511-96xp1v0r 110 19 research research NN cord-262511-96xp1v0r 110 20 in in IN cord-262511-96xp1v0r 110 21 recent recent JJ cord-262511-96xp1v0r 110 22 years year NNS cord-262511-96xp1v0r 110 23 , , , cord-262511-96xp1v0r 110 24 are be VBP cord-262511-96xp1v0r 110 25 RNA RNA NNP cord-262511-96xp1v0r 110 26 helicases helicase NNS cord-262511-96xp1v0r 110 27 , , , cord-262511-96xp1v0r 110 28 recognizing recognize VBG cord-262511-96xp1v0r 110 29 viral viral JJ cord-262511-96xp1v0r 110 30 dsRNA dsRNA NNS cord-262511-96xp1v0r 110 31 and and CC cord-262511-96xp1v0r 110 32 triggering trigger VBG cord-262511-96xp1v0r 110 33 IFN IFN NNP cord-262511-96xp1v0r 110 34 response response NN cord-262511-96xp1v0r 110 35 [ [ -LRB- cord-262511-96xp1v0r 110 36 61 61 CD cord-262511-96xp1v0r 110 37 ] ] -RRB- cord-262511-96xp1v0r 110 38 . . . cord-262511-96xp1v0r 111 1 Two two CD cord-262511-96xp1v0r 111 2 recent recent JJ cord-262511-96xp1v0r 111 3 studies study NNS cord-262511-96xp1v0r 111 4 have have VBP cord-262511-96xp1v0r 111 5 shown show VBN cord-262511-96xp1v0r 111 6 that that IN cord-262511-96xp1v0r 111 7 RIG rig NN cord-262511-96xp1v0r 111 8 - - : cord-262511-96xp1v0r 111 9 I -PRON- PRP cord-262511-96xp1v0r 111 10 can can MD cord-262511-96xp1v0r 111 11 distinguish distinguish VB cord-262511-96xp1v0r 111 12 viral viral JJ cord-262511-96xp1v0r 111 13 , , , cord-262511-96xp1v0r 111 14 uncapped uncapped JJ cord-262511-96xp1v0r 111 15 ssRNA ssrna RB cord-262511-96xp1v0r 111 16 from from IN cord-262511-96xp1v0r 111 17 cellular cellular JJ cord-262511-96xp1v0r 111 18 mRNAs mrnas CD cord-262511-96xp1v0r 111 19 [ [ -LRB- cord-262511-96xp1v0r 111 20 62 62 CD cord-262511-96xp1v0r 111 21 , , , cord-262511-96xp1v0r 111 22 63 63 CD cord-262511-96xp1v0r 111 23 ] ] -RRB- cord-262511-96xp1v0r 111 24 . . . cord-262511-96xp1v0r 112 1 These these DT cord-262511-96xp1v0r 112 2 proteins protein NNS cord-262511-96xp1v0r 112 3 and and CC cord-262511-96xp1v0r 112 4 their -PRON- PRP$ cord-262511-96xp1v0r 112 5 adaptors adaptor NNS cord-262511-96xp1v0r 112 6 have have VBP cord-262511-96xp1v0r 112 7 been be VBN cord-262511-96xp1v0r 112 8 explored explore VBN cord-262511-96xp1v0r 112 9 largely largely RB cord-262511-96xp1v0r 112 10 for for IN cord-262511-96xp1v0r 112 11 their -PRON- PRP$ cord-262511-96xp1v0r 112 12 transcriptional transcriptional JJ cord-262511-96xp1v0r 112 13 induction induction NN cord-262511-96xp1v0r 112 14 of of IN cord-262511-96xp1v0r 112 15 IFN IFN NNP cord-262511-96xp1v0r 112 16 regulatory regulatory JJ cord-262511-96xp1v0r 112 17 factor factor NN cord-262511-96xp1v0r 112 18 3-dependent 3-dependent CD cord-262511-96xp1v0r 112 19 IFN IFN NNP cord-262511-96xp1v0r 112 20 and and CC cord-262511-96xp1v0r 112 21 NF nf NN cord-262511-96xp1v0r 112 22 - - HYPH cord-262511-96xp1v0r 112 23 B b NN cord-262511-96xp1v0r 112 24 - - HYPH cord-262511-96xp1v0r 112 25 mediated mediate VBN cord-262511-96xp1v0r 112 26 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 112 27 cytokines cytokine NNS cord-262511-96xp1v0r 112 28 when when WRB cord-262511-96xp1v0r 112 29 compared compare VBN cord-262511-96xp1v0r 112 30 with with IN cord-262511-96xp1v0r 112 31 post post JJ cord-262511-96xp1v0r 112 32 - - JJ cord-262511-96xp1v0r 112 33 transcriptional transcriptional JJ cord-262511-96xp1v0r 112 34 effects effect NNS cord-262511-96xp1v0r 112 35 . . . cord-262511-96xp1v0r 113 1 Recently recently RB cord-262511-96xp1v0r 113 2 , , , cord-262511-96xp1v0r 113 3 it -PRON- PRP cord-262511-96xp1v0r 113 4 has have VBZ cord-262511-96xp1v0r 113 5 been be VBN cord-262511-96xp1v0r 113 6 shown show VBN cord-262511-96xp1v0r 113 7 that that IN cord-262511-96xp1v0r 113 8 a a DT cord-262511-96xp1v0r 113 9 constitutively constitutively RB cord-262511-96xp1v0r 113 10 active active JJ cord-262511-96xp1v0r 113 11 RIG rig NN cord-262511-96xp1v0r 113 12 - - : cord-262511-96xp1v0r 113 13 I i NN cord-262511-96xp1v0r 113 14 protein protein NN cord-262511-96xp1v0r 113 15 , , , cord-262511-96xp1v0r 113 16 RIG RIG NNP cord-262511-96xp1v0r 113 17 - - HYPH cord-262511-96xp1v0r 113 18 N N NNP cord-262511-96xp1v0r 113 19 , , , cord-262511-96xp1v0r 113 20 stabilizes stabilize VBZ cord-262511-96xp1v0r 114 1 TNF- tnf- JJ cord-262511-96xp1v0r 114 2 ␣ ␣ NN cord-262511-96xp1v0r 114 3 -induced -induce VBN cord-262511-96xp1v0r 115 1 IL-8 IL-8 NNP cord-262511-96xp1v0r 116 1 mRNA mRNA NNP cord-262511-96xp1v0r 116 2 and and CC cord-262511-96xp1v0r 116 3 increases increase VBZ cord-262511-96xp1v0r 116 4 reporter reporter NN cord-262511-96xp1v0r 116 5 activity activity NN cord-262511-96xp1v0r 116 6 from from IN cord-262511-96xp1v0r 116 7 a a DT cord-262511-96xp1v0r 116 8 construct construct NN cord-262511-96xp1v0r 116 9 that that WDT cord-262511-96xp1v0r 116 10 is be VBZ cord-262511-96xp1v0r 116 11 fused fuse VBN cord-262511-96xp1v0r 116 12 with with IN cord-262511-96xp1v0r 116 13 ARE are NN cord-262511-96xp1v0r 116 14 - - HYPH cord-262511-96xp1v0r 116 15 bearing bearing NN cord-262511-96xp1v0r 116 16 , , , cord-262511-96xp1v0r 117 1 IL-8 IL-8 NNP cord-262511-96xp1v0r 117 2 3ЈUTR 3ЈUTR NNP cord-262511-96xp1v0r 117 3 [ [ -LRB- cord-262511-96xp1v0r 117 4 64 64 CD cord-262511-96xp1v0r 117 5 ] ] -RRB- cord-262511-96xp1v0r 117 6 . . . cord-262511-96xp1v0r 118 1 IL-8 IL-8 NNP cord-262511-96xp1v0r 118 2 is be VBZ cord-262511-96xp1v0r 118 3 a a DT cord-262511-96xp1v0r 118 4 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 118 5 cytokine cytokine NN cord-262511-96xp1v0r 118 6 , , , cord-262511-96xp1v0r 118 7 which which WDT cord-262511-96xp1v0r 118 8 appears appear VBZ cord-262511-96xp1v0r 118 9 to to TO cord-262511-96xp1v0r 118 10 exaggerate exaggerate VB cord-262511-96xp1v0r 118 11 HCV HCV NNP cord-262511-96xp1v0r 118 12 - - HYPH cord-262511-96xp1v0r 118 13 induced induce VBN cord-262511-96xp1v0r 118 14 hepatitis hepatitis NN cord-262511-96xp1v0r 118 15 . . . cord-262511-96xp1v0r 119 1 Thus thus RB cord-262511-96xp1v0r 119 2 , , , cord-262511-96xp1v0r 119 3 HCV HCV NNP cord-262511-96xp1v0r 119 4 - - HYPH cord-262511-96xp1v0r 119 5 driven drive VBN cord-262511-96xp1v0r 119 6 stabilization stabilization NN cord-262511-96xp1v0r 119 7 of of IN cord-262511-96xp1v0r 119 8 IL-8 IL-8 NNP cord-262511-96xp1v0r 119 9 mRNA mRNA NNP cord-262511-96xp1v0r 119 10 may may MD cord-262511-96xp1v0r 119 11 explain explain VB cord-262511-96xp1v0r 119 12 , , , cord-262511-96xp1v0r 119 13 at at IN cord-262511-96xp1v0r 119 14 least least JJS cord-262511-96xp1v0r 119 15 in in IN cord-262511-96xp1v0r 119 16 part part NN cord-262511-96xp1v0r 119 17 , , , cord-262511-96xp1v0r 119 18 the the DT cord-262511-96xp1v0r 119 19 increased increase VBN cord-262511-96xp1v0r 119 20 IL-8 il-8 NN cord-262511-96xp1v0r 119 21 levels level NNS cord-262511-96xp1v0r 119 22 seen see VBN cord-262511-96xp1v0r 119 23 in in IN cord-262511-96xp1v0r 119 24 the the DT cord-262511-96xp1v0r 119 25 sera sera NNP cord-262511-96xp1v0r 119 26 of of IN cord-262511-96xp1v0r 119 27 HCV HCV NNP cord-262511-96xp1v0r 119 28 patients patient NNS cord-262511-96xp1v0r 119 29 and and CC cord-262511-96xp1v0r 119 30 those those DT cord-262511-96xp1v0r 119 31 that that WDT cord-262511-96xp1v0r 119 32 are be VBP cord-262511-96xp1v0r 119 33 nonresponsive nonresponsive JJ cord-262511-96xp1v0r 119 34 to to IN cord-262511-96xp1v0r 119 35 IFN IFN NNP cord-262511-96xp1v0r 119 36 therapy therapy NN cord-262511-96xp1v0r 119 37 [ [ -LRB- cord-262511-96xp1v0r 119 38 65 65 CD cord-262511-96xp1v0r 119 39 ] ] -RRB- cord-262511-96xp1v0r 119 40 . . . cord-262511-96xp1v0r 120 1 For for IN cord-262511-96xp1v0r 120 2 successful successful JJ cord-262511-96xp1v0r 120 3 takeover takeover NN cord-262511-96xp1v0r 120 4 of of IN cord-262511-96xp1v0r 120 5 cell cell NN cord-262511-96xp1v0r 120 6 machinery machinery NN cord-262511-96xp1v0r 120 7 for for IN cord-262511-96xp1v0r 120 8 their -PRON- PRP$ cord-262511-96xp1v0r 120 9 own own JJ cord-262511-96xp1v0r 120 10 growth growth NN cord-262511-96xp1v0r 120 11 , , , cord-262511-96xp1v0r 120 12 viruses virus NNS cord-262511-96xp1v0r 120 13 have have VBP cord-262511-96xp1v0r 120 14 the the DT cord-262511-96xp1v0r 120 15 ability ability NN cord-262511-96xp1v0r 120 16 to to TO cord-262511-96xp1v0r 120 17 shut shut VB cord-262511-96xp1v0r 120 18 - - HYPH cord-262511-96xp1v0r 120 19 off off RP cord-262511-96xp1v0r 120 20 cellular cellular JJ cord-262511-96xp1v0r 120 21 mRNA mrna NN cord-262511-96xp1v0r 120 22 biogenesis biogenesis NN cord-262511-96xp1v0r 120 23 and and CC cord-262511-96xp1v0r 120 24 induce induce VB cord-262511-96xp1v0r 120 25 rapid rapid JJ cord-262511-96xp1v0r 120 26 degradation degradation NN cord-262511-96xp1v0r 120 27 of of IN cord-262511-96xp1v0r 120 28 selected select VBN cord-262511-96xp1v0r 120 29 cellular cellular JJ cord-262511-96xp1v0r 120 30 mRNAs mrna NNS cord-262511-96xp1v0r 120 31 , , , cord-262511-96xp1v0r 120 32 particularly particularly RB cord-262511-96xp1v0r 120 33 those those DT cord-262511-96xp1v0r 120 34 required require VBN cord-262511-96xp1v0r 120 35 for for IN cord-262511-96xp1v0r 120 36 host host NN cord-262511-96xp1v0r 120 37 defense defense NN cord-262511-96xp1v0r 120 38 . . . cord-262511-96xp1v0r 121 1 For for IN cord-262511-96xp1v0r 121 2 example example NN cord-262511-96xp1v0r 121 3 , , , cord-262511-96xp1v0r 121 4 the the DT cord-262511-96xp1v0r 121 5 nonstructural nonstructural JJ cord-262511-96xp1v0r 121 6 protein protein NN cord-262511-96xp1v0r 121 7 , , , cord-262511-96xp1v0r 121 8 nsp1 nsp1 NNS cord-262511-96xp1v0r 121 9 , , , cord-262511-96xp1v0r 121 10 from from IN cord-262511-96xp1v0r 121 11 the the DT cord-262511-96xp1v0r 121 12 severe severe JJ cord-262511-96xp1v0r 121 13 acute acute JJ cord-262511-96xp1v0r 121 14 respiratory respiratory JJ cord-262511-96xp1v0r 121 15 syndrome syndrome NN cord-262511-96xp1v0r 121 16 coronavirus coronavirus NN cord-262511-96xp1v0r 121 17 , , , cord-262511-96xp1v0r 121 18 suppresses suppress VBZ cord-262511-96xp1v0r 121 19 IFN- IFN- NNP cord-262511-96xp1v0r 121 20 ␤ ␤ CD cord-262511-96xp1v0r 121 21 production production NN cord-262511-96xp1v0r 121 22 at at IN cord-262511-96xp1v0r 121 23 a a DT cord-262511-96xp1v0r 121 24 post post JJ cord-262511-96xp1v0r 121 25 - - JJ cord-262511-96xp1v0r 121 26 transcriptional transcriptional JJ cord-262511-96xp1v0r 121 27 level level NN cord-262511-96xp1v0r 121 28 by by IN cord-262511-96xp1v0r 121 29 increasing increase VBG cord-262511-96xp1v0r 121 30 its -PRON- PRP$ cord-262511-96xp1v0r 121 31 mRNA mrna NN cord-262511-96xp1v0r 121 32 decay decay NN cord-262511-96xp1v0r 121 33 [ [ -LRB- cord-262511-96xp1v0r 121 34 66 66 CD cord-262511-96xp1v0r 121 35 ] ] -RRB- cord-262511-96xp1v0r 121 36 . . . cord-262511-96xp1v0r 122 1 Cytomegalovirus Cytomegalovirus NNP cord-262511-96xp1v0r 122 2 is be VBZ cord-262511-96xp1v0r 122 3 able able JJ cord-262511-96xp1v0r 122 4 to to TO cord-262511-96xp1v0r 122 5 destabilize destabilize VB cord-262511-96xp1v0r 122 6 IL-6 IL-6 NNP cord-262511-96xp1v0r 122 7 mRNA mrna NN cord-262511-96xp1v0r 122 8 with with IN cord-262511-96xp1v0r 122 9 concomitant concomitant JJ cord-262511-96xp1v0r 122 10 translocation translocation NN cord-262511-96xp1v0r 122 11 of of IN cord-262511-96xp1v0r 122 12 HuR hur NN cord-262511-96xp1v0r 122 13 to to IN cord-262511-96xp1v0r 122 14 the the DT cord-262511-96xp1v0r 122 15 cytoplasmic cytoplasmic JJ cord-262511-96xp1v0r 122 16 compartment compartment NN cord-262511-96xp1v0r 122 17 [ [ -LRB- cord-262511-96xp1v0r 122 18 67 67 CD cord-262511-96xp1v0r 122 19 ] ] -RRB- cord-262511-96xp1v0r 122 20 , , , cord-262511-96xp1v0r 122 21 although although IN cord-262511-96xp1v0r 122 22 this this DT cord-262511-96xp1v0r 122 23 process process NN cord-262511-96xp1v0r 122 24 is be VBZ cord-262511-96xp1v0r 122 25 usually usually RB cord-262511-96xp1v0r 122 26 known know VBN cord-262511-96xp1v0r 122 27 to to TO cord-262511-96xp1v0r 122 28 cause cause VB cord-262511-96xp1v0r 122 29 up up RP cord-262511-96xp1v0r 122 30 - - HYPH cord-262511-96xp1v0r 122 31 regulation regulation NN cord-262511-96xp1v0r 122 32 of of IN cord-262511-96xp1v0r 122 33 ARE are VBP cord-262511-96xp1v0r 122 34 and and CC cord-262511-96xp1v0r 122 35 ARE are VBP cord-262511-96xp1v0r 122 36 - - HYPH cord-262511-96xp1v0r 122 37 like like RB cord-262511-96xp1v0r 122 38 - - HYPH cord-262511-96xp1v0r 122 39 containing contain VBG cord-262511-96xp1v0r 122 40 mRNA mrna NN cord-262511-96xp1v0r 122 41 [ [ -LRB- cord-262511-96xp1v0r 122 42 68 68 CD cord-262511-96xp1v0r 122 43 ] ] -RRB- cord-262511-96xp1v0r 122 44 . . . cord-262511-96xp1v0r 123 1 The the DT cord-262511-96xp1v0r 123 2 HSV-1 HSV-1 NNS cord-262511-96xp1v0r 123 3 open open JJ cord-262511-96xp1v0r 123 4 - - HYPH cord-262511-96xp1v0r 123 5 reading read VBG cord-262511-96xp1v0r 123 6 frame frame NN cord-262511-96xp1v0r 123 7 UL41 UL41 NNP cord-262511-96xp1v0r 123 8 , , , cord-262511-96xp1v0r 123 9 which which WDT cord-262511-96xp1v0r 123 10 encodes encode VBZ cord-262511-96xp1v0r 123 11 virion virion NN cord-262511-96xp1v0r 123 12 host host NN cord-262511-96xp1v0r 123 13 shut shut VBN cord-262511-96xp1v0r 123 14 - - HYPH cord-262511-96xp1v0r 123 15 off off NN cord-262511-96xp1v0r 123 16 or or CC cord-262511-96xp1v0r 123 17 vhs vhs NN cord-262511-96xp1v0r 123 18 , , , cord-262511-96xp1v0r 123 19 can can MD cord-262511-96xp1v0r 123 20 act act VB cord-262511-96xp1v0r 123 21 as as IN cord-262511-96xp1v0r 123 22 an an DT cord-262511-96xp1v0r 123 23 endoRNase endornase NN cord-262511-96xp1v0r 123 24 or or CC cord-262511-96xp1v0r 123 25 a a DT cord-262511-96xp1v0r 123 26 component component NN cord-262511-96xp1v0r 123 27 of of IN cord-262511-96xp1v0r 123 28 the the DT cord-262511-96xp1v0r 123 29 RNase rnase NN cord-262511-96xp1v0r 123 30 complex complex NN cord-262511-96xp1v0r 123 31 , , , cord-262511-96xp1v0r 123 32 degrading degrade VBG cord-262511-96xp1v0r 123 33 cellular cellular JJ cord-262511-96xp1v0r 123 34 mRNAs mrnas CD cord-262511-96xp1v0r 124 1 such such JJ cord-262511-96xp1v0r 124 2 IEX-1 IEX-1 NNP cord-262511-96xp1v0r 124 3 mRNA mrna NN cord-262511-96xp1v0r 124 4 [ [ -LRB- cord-262511-96xp1v0r 124 5 69 69 CD cord-262511-96xp1v0r 124 6 ] ] -RRB- cord-262511-96xp1v0r 124 7 , , , cord-262511-96xp1v0r 124 8 although although IN cord-262511-96xp1v0r 124 9 this this DT cord-262511-96xp1v0r 124 10 study study NN cord-262511-96xp1v0r 124 11 is be VBZ cord-262511-96xp1v0r 124 12 in in IN cord-262511-96xp1v0r 124 13 conflict conflict NN cord-262511-96xp1v0r 124 14 with with IN cord-262511-96xp1v0r 124 15 other other JJ cord-262511-96xp1v0r 124 16 reports report NNS cord-262511-96xp1v0r 124 17 that that IN cord-262511-96xp1v0r 124 18 HSV-1 HSV-1 NNP cord-262511-96xp1v0r 124 19 infection infection NN cord-262511-96xp1v0r 124 20 leads lead VBZ cord-262511-96xp1v0r 124 21 to to IN cord-262511-96xp1v0r 124 22 IEX-1 IEX-1 NNP cord-262511-96xp1v0r 124 23 mRNA mRNA NNP cord-262511-96xp1v0r 124 24 stabilization stabilization NN cord-262511-96xp1v0r 124 25 [ [ -LRB- cord-262511-96xp1v0r 124 26 55 55 CD cord-262511-96xp1v0r 124 27 , , , cord-262511-96xp1v0r 124 28 56 56 CD cord-262511-96xp1v0r 124 29 ] ] -RRB- cord-262511-96xp1v0r 124 30 . . . cord-262511-96xp1v0r 125 1 This this DT cord-262511-96xp1v0r 125 2 discrepancy discrepancy NN cord-262511-96xp1v0r 125 3 may may MD cord-262511-96xp1v0r 125 4 be be VB cord-262511-96xp1v0r 125 5 a a DT cord-262511-96xp1v0r 125 6 result result NN cord-262511-96xp1v0r 125 7 of of IN cord-262511-96xp1v0r 125 8 the the DT cord-262511-96xp1v0r 125 9 presence presence NN cord-262511-96xp1v0r 125 10 of of IN cord-262511-96xp1v0r 125 11 alternative alternative JJ cord-262511-96xp1v0r 125 12 forms form NNS cord-262511-96xp1v0r 125 13 of of IN cord-262511-96xp1v0r 125 14 transcripts transcript NNS cord-262511-96xp1v0r 125 15 with with IN cord-262511-96xp1v0r 125 16 different different JJ cord-262511-96xp1v0r 125 17 regulatory regulatory JJ cord-262511-96xp1v0r 125 18 responses response NNS cord-262511-96xp1v0r 125 19 owing owe VBG cord-262511-96xp1v0r 125 20 to to IN cord-262511-96xp1v0r 125 21 inclusion inclusion NN cord-262511-96xp1v0r 125 22 or or CC cord-262511-96xp1v0r 125 23 exclusion exclusion NN cord-262511-96xp1v0r 125 24 of of IN cord-262511-96xp1v0r 125 25 AREs ares NN cord-262511-96xp1v0r 125 26 through through IN cord-262511-96xp1v0r 125 27 alternative alternative JJ cord-262511-96xp1v0r 125 28 splicing splicing NN cord-262511-96xp1v0r 125 29 and and CC cord-262511-96xp1v0r 125 30 polyadenylation polyadenylation NN cord-262511-96xp1v0r 125 31 [ [ -LRB- cord-262511-96xp1v0r 125 32 70 70 CD cord-262511-96xp1v0r 125 33 ] ] -RRB- cord-262511-96xp1v0r 125 34 . . . cord-262511-96xp1v0r 126 1 Can Can MD cord-262511-96xp1v0r 126 2 the the DT cord-262511-96xp1v0r 126 3 RNA RNA NNP cord-262511-96xp1v0r 126 4 decay decay NN cord-262511-96xp1v0r 126 5 - - HYPH cord-262511-96xp1v0r 126 6 promoting promote VBG cord-262511-96xp1v0r 126 7 activity activity NN cord-262511-96xp1v0r 126 8 of of IN cord-262511-96xp1v0r 126 9 the the DT cord-262511-96xp1v0r 126 10 RNA RNA NNP cord-262511-96xp1v0r 126 11 - - HYPH cord-262511-96xp1v0r 126 12 binding bind VBG cord-262511-96xp1v0r 126 13 proteins protein NNS cord-262511-96xp1v0r 126 14 be be VB cord-262511-96xp1v0r 126 15 harnessed harness VBN cord-262511-96xp1v0r 126 16 as as IN cord-262511-96xp1v0r 126 17 an an DT cord-262511-96xp1v0r 126 18 antiviral antiviral JJ cord-262511-96xp1v0r 126 19 therapeutic therapeutic JJ cord-262511-96xp1v0r 126 20 strategy strategy NN cord-262511-96xp1v0r 126 21 ? ? . cord-262511-96xp1v0r 127 1 Two two CD cord-262511-96xp1v0r 127 2 recent recent JJ cord-262511-96xp1v0r 127 3 reports report NNS cord-262511-96xp1v0r 127 4 show show VBP cord-262511-96xp1v0r 127 5 that that IN cord-262511-96xp1v0r 127 6 this this DT cord-262511-96xp1v0r 127 7 is be VBZ cord-262511-96xp1v0r 127 8 a a DT cord-262511-96xp1v0r 127 9 possibility possibility NN cord-262511-96xp1v0r 127 10 [ [ -LRB- cord-262511-96xp1v0r 127 11 9 9 CD cord-262511-96xp1v0r 127 12 , , , cord-262511-96xp1v0r 127 13 71 71 CD cord-262511-96xp1v0r 127 14 ] ] -RRB- cord-262511-96xp1v0r 127 15 . . . cord-262511-96xp1v0r 128 1 KSRP KSRP NNP cord-262511-96xp1v0r 128 2 has have VBZ cord-262511-96xp1v0r 128 3 been be VBN cord-262511-96xp1v0r 128 4 tethered tether VBN cord-262511-96xp1v0r 128 5 to to IN cord-262511-96xp1v0r 128 6 the the DT cord-262511-96xp1v0r 128 7 HIV HIV NNP cord-262511-96xp1v0r 128 8 Type Type NNP cord-262511-96xp1v0r 128 9 1 1 CD cord-262511-96xp1v0r 128 10 Rev Rev NNP cord-262511-96xp1v0r 128 11 protein protein NN cord-262511-96xp1v0r 128 12 , , , cord-262511-96xp1v0r 128 13 essential essential JJ cord-262511-96xp1v0r 128 14 in in IN cord-262511-96xp1v0r 128 15 the the DT cord-262511-96xp1v0r 128 16 HIV HIV NNP cord-262511-96xp1v0r 128 17 life life NN cord-262511-96xp1v0r 128 18 cycle cycle NN cord-262511-96xp1v0r 128 19 , , , cord-262511-96xp1v0r 128 20 and and CC cord-262511-96xp1v0r 128 21 binds bind VBZ cord-262511-96xp1v0r 128 22 a a DT cord-262511-96xp1v0r 128 23 specific specific JJ cord-262511-96xp1v0r 128 24 response response NN cord-262511-96xp1v0r 128 25 element element NN cord-262511-96xp1v0r 128 26 in in IN cord-262511-96xp1v0r 128 27 HIV HIV NNP cord-262511-96xp1v0r 128 28 RNA RNA NNP cord-262511-96xp1v0r 128 29 . . . cord-262511-96xp1v0r 129 1 The the DT cord-262511-96xp1v0r 129 2 KSRP KSRP NNP cord-262511-96xp1v0r 129 3 - - HYPH cord-262511-96xp1v0r 129 4 Rev Rev NNP cord-262511-96xp1v0r 129 5 is be VBZ cord-262511-96xp1v0r 129 6 able able JJ cord-262511-96xp1v0r 129 7 to to TO cord-262511-96xp1v0r 129 8 bind bind VB cord-262511-96xp1v0r 129 9 to to IN cord-262511-96xp1v0r 129 10 HIV HIV NNP cord-262511-96xp1v0r 129 11 RNA RNA NNP cord-262511-96xp1v0r 129 12 and and CC cord-262511-96xp1v0r 129 13 triggers trigger VBZ cord-262511-96xp1v0r 129 14 its -PRON- PRP$ cord-262511-96xp1v0r 129 15 degradation degradation NN cord-262511-96xp1v0r 129 16 , , , cord-262511-96xp1v0r 129 17 leading lead VBG cord-262511-96xp1v0r 129 18 to to IN cord-262511-96xp1v0r 129 19 a a DT cord-262511-96xp1v0r 129 20 dramatic dramatic JJ cord-262511-96xp1v0r 129 21 reduction reduction NN cord-262511-96xp1v0r 129 22 in in IN cord-262511-96xp1v0r 129 23 HIV HIV NNP cord-262511-96xp1v0r 129 24 repli repli NNP cord-262511-96xp1v0r 129 25 - - HYPH cord-262511-96xp1v0r 129 26 cation cation NN cord-262511-96xp1v0r 129 27 [ [ -LRB- cord-262511-96xp1v0r 129 28 9 9 CD cord-262511-96xp1v0r 129 29 ] ] -RRB- cord-262511-96xp1v0r 129 30 . . . cord-262511-96xp1v0r 130 1 Likewise likewise RB cord-262511-96xp1v0r 130 2 , , , cord-262511-96xp1v0r 130 3 TTP TTP NNP cord-262511-96xp1v0r 130 4 can can MD cord-262511-96xp1v0r 130 5 be be VB cord-262511-96xp1v0r 130 6 used use VBN cord-262511-96xp1v0r 130 7 in in IN cord-262511-96xp1v0r 130 8 the the DT cord-262511-96xp1v0r 130 9 same same JJ cord-262511-96xp1v0r 130 10 manner manner NN cord-262511-96xp1v0r 130 11 , , , cord-262511-96xp1v0r 130 12 probably probably RB cord-262511-96xp1v0r 130 13 with with IN cord-262511-96xp1v0r 130 14 an an DT cord-262511-96xp1v0r 130 15 additional additional JJ cord-262511-96xp1v0r 130 16 advantage advantage NN cord-262511-96xp1v0r 130 17 : : : cord-262511-96xp1v0r 130 18 TTP TTP NNP cord-262511-96xp1v0r 130 19 binds bind VBZ cord-262511-96xp1v0r 130 20 directly directly RB cord-262511-96xp1v0r 130 21 to to IN cord-262511-96xp1v0r 130 22 the the DT cord-262511-96xp1v0r 130 23 AU AU NNP cord-262511-96xp1v0r 130 24 - - HYPH cord-262511-96xp1v0r 130 25 rich rich JJ cord-262511-96xp1v0r 130 26 HIV-1 HIV-1 NNP cord-262511-96xp1v0r 130 27 RNA RNA NNP cord-262511-96xp1v0r 130 28 and and CC cord-262511-96xp1v0r 130 29 enhances enhance VBZ cord-262511-96xp1v0r 130 30 multiple multiple JJ cord-262511-96xp1v0r 130 31 splicing splicing NN cord-262511-96xp1v0r 130 32 , , , cord-262511-96xp1v0r 130 33 which which WDT cord-262511-96xp1v0r 130 34 leads lead VBZ cord-262511-96xp1v0r 130 35 to to IN cord-262511-96xp1v0r 130 36 a a DT cord-262511-96xp1v0r 130 37 reduction reduction NN cord-262511-96xp1v0r 130 38 of of IN cord-262511-96xp1v0r 130 39 HIV-1 HIV-1 NNP cord-262511-96xp1v0r 130 40 virions virion NNS cord-262511-96xp1v0r 130 41 [ [ -LRB- cord-262511-96xp1v0r 130 42 71 71 CD cord-262511-96xp1v0r 130 43 ] ] -RRB- cord-262511-96xp1v0r 130 44 . . . cord-262511-96xp1v0r 131 1 Activation activation NN cord-262511-96xp1v0r 131 2 of of IN cord-262511-96xp1v0r 131 3 lymphocytes lymphocyte NNS cord-262511-96xp1v0r 131 4 is be VBZ cord-262511-96xp1v0r 131 5 fundamental fundamental JJ cord-262511-96xp1v0r 131 6 to to IN cord-262511-96xp1v0r 131 7 the the DT cord-262511-96xp1v0r 131 8 immune immune JJ cord-262511-96xp1v0r 131 9 response response NN cord-262511-96xp1v0r 131 10 to to IN cord-262511-96xp1v0r 131 11 antigens antigen NNS cord-262511-96xp1v0r 131 12 and and CC cord-262511-96xp1v0r 131 13 requires require VBZ cord-262511-96xp1v0r 131 14 two two CD cord-262511-96xp1v0r 131 15 main main JJ cord-262511-96xp1v0r 131 16 signals signal NNS cord-262511-96xp1v0r 131 17 . . . cord-262511-96xp1v0r 132 1 One one CD cord-262511-96xp1v0r 132 2 signal signal NN cord-262511-96xp1v0r 132 3 is be VBZ cord-262511-96xp1v0r 132 4 provided provide VBN cord-262511-96xp1v0r 132 5 upon upon IN cord-262511-96xp1v0r 132 6 the the DT cord-262511-96xp1v0r 132 7 engagement engagement NN cord-262511-96xp1v0r 132 8 of of IN cord-262511-96xp1v0r 132 9 TcR TcR NNP cord-262511-96xp1v0r 132 10 with with IN cord-262511-96xp1v0r 132 11 the the DT cord-262511-96xp1v0r 132 12 antigen antigen NN cord-262511-96xp1v0r 132 13 presented present VBN cord-262511-96xp1v0r 132 14 with with IN cord-262511-96xp1v0r 132 15 MHC MHC NNP cord-262511-96xp1v0r 132 16 on on IN cord-262511-96xp1v0r 132 17 APCs apc NNS cord-262511-96xp1v0r 132 18 . . . cord-262511-96xp1v0r 133 1 The the DT cord-262511-96xp1v0r 133 2 other other JJ cord-262511-96xp1v0r 133 3 is be VBZ cord-262511-96xp1v0r 133 4 delivered deliver VBN cord-262511-96xp1v0r 133 5 by by IN cord-262511-96xp1v0r 133 6 costimulatory costimulatory NN cord-262511-96xp1v0r 133 7 molecules molecule NNS cord-262511-96xp1v0r 133 8 , , , cord-262511-96xp1v0r 133 9 such such JJ cord-262511-96xp1v0r 133 10 as as IN cord-262511-96xp1v0r 133 11 lymphocyte lymphocyte NN cord-262511-96xp1v0r 133 12 function function NN cord-262511-96xp1v0r 133 13 - - HYPH cord-262511-96xp1v0r 133 14 associated associate VBN cord-262511-96xp1v0r 133 15 protein protein NN cord-262511-96xp1v0r 133 16 1 1 CD cord-262511-96xp1v0r 133 17 ( ( -LRB- cord-262511-96xp1v0r 133 18 LFA-1 LFA-1 NNP cord-262511-96xp1v0r 133 19 ) ) -RRB- cord-262511-96xp1v0r 133 20 , , , cord-262511-96xp1v0r 133 21 CD2 CD2 NNP cord-262511-96xp1v0r 133 22 , , , cord-262511-96xp1v0r 133 23 and and CC cord-262511-96xp1v0r 133 24 CD28 CD28 NNP cord-262511-96xp1v0r 133 25 on on IN cord-262511-96xp1v0r 133 26 T T NNP cord-262511-96xp1v0r 133 27 cells cell NNS cord-262511-96xp1v0r 133 28 , , , cord-262511-96xp1v0r 133 29 when when WRB cord-262511-96xp1v0r 133 30 they -PRON- PRP cord-262511-96xp1v0r 133 31 interact interact VBP cord-262511-96xp1v0r 133 32 with with IN cord-262511-96xp1v0r 133 33 cognate cognate JJ cord-262511-96xp1v0r 133 34 receptors receptor NNS cord-262511-96xp1v0r 133 35 on on IN cord-262511-96xp1v0r 133 36 the the DT cord-262511-96xp1v0r 133 37 APCs apc NNS cord-262511-96xp1v0r 133 38 . . . cord-262511-96xp1v0r 134 1 With with IN cord-262511-96xp1v0r 134 2 these these DT cord-262511-96xp1v0r 134 3 two two CD cord-262511-96xp1v0r 134 4 signals signal NNS cord-262511-96xp1v0r 134 5 , , , cord-262511-96xp1v0r 134 6 the the DT cord-262511-96xp1v0r 134 7 result result NN cord-262511-96xp1v0r 134 8 is be VBZ cord-262511-96xp1v0r 134 9 AP-1 AP-1 NNP cord-262511-96xp1v0r 134 10 ( ( -LRB- cord-262511-96xp1v0r 134 11 c c NN cord-262511-96xp1v0r 134 12 - - HYPH cord-262511-96xp1v0r 134 13 fos fos NNP cord-262511-96xp1v0r 134 14 / / SYM cord-262511-96xp1v0r 134 15 Jun Jun NNP cord-262511-96xp1v0r 134 16 ) ) -RRB- cord-262511-96xp1v0r 134 17 induction induction NN cord-262511-96xp1v0r 134 18 and and CC cord-262511-96xp1v0r 134 19 commitment commitment NN cord-262511-96xp1v0r 134 20 production production NN cord-262511-96xp1v0r 134 21 of of IN cord-262511-96xp1v0r 134 22 IL-2 IL-2 NNP cord-262511-96xp1v0r 134 23 , , , cord-262511-96xp1v0r 134 24 the the DT cord-262511-96xp1v0r 134 25 hallmark hallmark NN cord-262511-96xp1v0r 134 26 of of IN cord-262511-96xp1v0r 134 27 T T NNP cord-262511-96xp1v0r 134 28 cell cell NN cord-262511-96xp1v0r 134 29 activation activation NN cord-262511-96xp1v0r 134 30 and and CC cord-262511-96xp1v0r 134 31 differentiation differentiation NN cord-262511-96xp1v0r 134 32 [ [ -LRB- cord-262511-96xp1v0r 134 33 72 72 CD cord-262511-96xp1v0r 134 34 ] ] -RRB- cord-262511-96xp1v0r 134 35 . . . cord-262511-96xp1v0r 135 1 Post post JJ cord-262511-96xp1v0r 135 2 - - JJ cord-262511-96xp1v0r 135 3 transcriptional transcriptional JJ cord-262511-96xp1v0r 135 4 control control NN cord-262511-96xp1v0r 135 5 plays play VBZ cord-262511-96xp1v0r 135 6 an an DT cord-262511-96xp1v0r 135 7 important important JJ cord-262511-96xp1v0r 135 8 regulatory regulatory JJ cord-262511-96xp1v0r 135 9 role role NN cord-262511-96xp1v0r 135 10 in in IN cord-262511-96xp1v0r 135 11 almost almost RB cord-262511-96xp1v0r 135 12 all all DT cord-262511-96xp1v0r 135 13 of of IN cord-262511-96xp1v0r 135 14 the the DT cord-262511-96xp1v0r 135 15 events event NNS cord-262511-96xp1v0r 135 16 that that WDT cord-262511-96xp1v0r 135 17 lead lead VBP cord-262511-96xp1v0r 135 18 to to IN cord-262511-96xp1v0r 135 19 transcriptional transcriptional JJ cord-262511-96xp1v0r 135 20 activation activation NN cord-262511-96xp1v0r 135 21 ( ( -LRB- cord-262511-96xp1v0r 135 22 Fig Fig NNP cord-262511-96xp1v0r 135 23 . . NNP cord-262511-96xp1v0r 135 24 2 2 CD cord-262511-96xp1v0r 135 25 ) ) -RRB- cord-262511-96xp1v0r 135 26 . . . cord-262511-96xp1v0r 136 1 A a DT cord-262511-96xp1v0r 136 2 large large JJ cord-262511-96xp1v0r 136 3 proportion proportion NN cord-262511-96xp1v0r 136 4 of of IN cord-262511-96xp1v0r 136 5 genes gene NNS cord-262511-96xp1v0r 136 6 is be VBZ cord-262511-96xp1v0r 136 7 regulated regulate VBN cord-262511-96xp1v0r 136 8 by by IN cord-262511-96xp1v0r 136 9 mRNA mrna NN cord-262511-96xp1v0r 136 10 stability stability NN cord-262511-96xp1v0r 136 11 , , , cord-262511-96xp1v0r 136 12 as as IN cord-262511-96xp1v0r 136 13 revealed reveal VBN cord-262511-96xp1v0r 136 14 with with IN cord-262511-96xp1v0r 136 15 the the DT cord-262511-96xp1v0r 136 16 large large JJ cord-262511-96xp1v0r 136 17 - - HYPH cord-262511-96xp1v0r 136 18 scale scale NN cord-262511-96xp1v0r 136 19 , , , cord-262511-96xp1v0r 136 20 gene gene NN cord-262511-96xp1v0r 136 21 - - HYPH cord-262511-96xp1v0r 136 22 expression expression NN cord-262511-96xp1v0r 136 23 profiling profiling NN cord-262511-96xp1v0r 136 24 in in IN cord-262511-96xp1v0r 136 25 activated activate VBN cord-262511-96xp1v0r 136 26 T t NN cord-262511-96xp1v0r 136 27 cells cell NNS cord-262511-96xp1v0r 136 28 [ [ -LRB- cord-262511-96xp1v0r 136 29 73 73 CD cord-262511-96xp1v0r 136 30 , , , cord-262511-96xp1v0r 136 31 74 74 CD cord-262511-96xp1v0r 136 32 ] ] -RRB- cord-262511-96xp1v0r 136 33 . . . cord-262511-96xp1v0r 137 1 One one CD cord-262511-96xp1v0r 137 2 of of IN cord-262511-96xp1v0r 137 3 the the DT cord-262511-96xp1v0r 137 4 most most RBS cord-262511-96xp1v0r 137 5 important important JJ cord-262511-96xp1v0r 137 6 signaling signal VBG cord-262511-96xp1v0r 137 7 events event NNS cord-262511-96xp1v0r 137 8 in in IN cord-262511-96xp1v0r 137 9 T T NNP cord-262511-96xp1v0r 137 10 cell cell NN cord-262511-96xp1v0r 137 11 activation activation NN cord-262511-96xp1v0r 137 12 that that WDT cord-262511-96xp1v0r 137 13 results result VBZ cord-262511-96xp1v0r 137 14 in in IN cord-262511-96xp1v0r 137 15 stabilization stabilization NN cord-262511-96xp1v0r 137 16 of of IN cord-262511-96xp1v0r 137 17 cytokines cytokine NNS cord-262511-96xp1v0r 137 18 , , , cord-262511-96xp1v0r 137 19 such such JJ cord-262511-96xp1v0r 137 20 as as IN cord-262511-96xp1v0r 137 21 IL-2 IL-2 NNP cord-262511-96xp1v0r 137 22 , , , cord-262511-96xp1v0r 137 23 IFN- IFN- NNP cord-262511-96xp1v0r 137 24 ␥ ␥ NNP cord-262511-96xp1v0r 137 25 , , , cord-262511-96xp1v0r 138 1 TNF- TNF- NNP cord-262511-96xp1v0r 138 2 ␣ ␣ NN cord-262511-96xp1v0r 138 3 , , , cord-262511-96xp1v0r 138 4 and and CC cord-262511-96xp1v0r 138 5 GM GM NNP cord-262511-96xp1v0r 138 6 - - HYPH cord-262511-96xp1v0r 138 7 CSF CSF NNP cord-262511-96xp1v0r 138 8 , , , cord-262511-96xp1v0r 138 9 is be VBZ cord-262511-96xp1v0r 138 10 induced induce VBN cord-262511-96xp1v0r 138 11 by by IN cord-262511-96xp1v0r 138 12 the the DT cord-262511-96xp1v0r 138 13 costimulatory costimulatory NNP cord-262511-96xp1v0r 138 14 CD28 CD28 NNP cord-262511-96xp1v0r 138 15 [ [ -LRB- cord-262511-96xp1v0r 138 16 75 75 CD cord-262511-96xp1v0r 138 17 ] ] -RRB- cord-262511-96xp1v0r 138 18 . . . cord-262511-96xp1v0r 139 1 This this DT cord-262511-96xp1v0r 139 2 signaling signal VBG cord-262511-96xp1v0r 139 3 pathway pathway NN cord-262511-96xp1v0r 139 4 does do VBZ cord-262511-96xp1v0r 139 5 not not RB cord-262511-96xp1v0r 139 6 only only RB cord-262511-96xp1v0r 139 7 increase increase VB cord-262511-96xp1v0r 139 8 the the DT cord-262511-96xp1v0r 139 9 promoter promoter NN cord-262511-96xp1v0r 139 10 activity activity NN cord-262511-96xp1v0r 139 11 of of IN cord-262511-96xp1v0r 139 12 the the DT cord-262511-96xp1v0r 139 13 cytokines cytokine NNS cord-262511-96xp1v0r 139 14 [ [ -LRB- cord-262511-96xp1v0r 139 15 76 76 CD cord-262511-96xp1v0r 139 16 ] ] -RRB- cord-262511-96xp1v0r 139 17 but but CC cord-262511-96xp1v0r 139 18 also also RB cord-262511-96xp1v0r 139 19 stabilizes stabilize VBZ cord-262511-96xp1v0r 139 20 their -PRON- PRP$ cord-262511-96xp1v0r 139 21 mRNAs mrnas XX cord-262511-96xp1v0r 139 22 [ [ -LRB- cord-262511-96xp1v0r 139 23 75 75 CD cord-262511-96xp1v0r 139 24 ] ] -RRB- cord-262511-96xp1v0r 139 25 . . . cord-262511-96xp1v0r 140 1 The the DT cord-262511-96xp1v0r 140 2 increased increase VBN cord-262511-96xp1v0r 140 3 IL-2 IL-2 NNP cord-262511-96xp1v0r 140 4 mRNA mRNA NNP cord-262511-96xp1v0r 140 5 stability stability NN cord-262511-96xp1v0r 140 6 is be VBZ cord-262511-96xp1v0r 140 7 thought think VBN cord-262511-96xp1v0r 140 8 to to TO cord-262511-96xp1v0r 140 9 be be VB cord-262511-96xp1v0r 140 10 controlled control VBN cord-262511-96xp1v0r 140 11 differently differently RB cord-262511-96xp1v0r 140 12 and and CC cord-262511-96xp1v0r 140 13 independent independent JJ cord-262511-96xp1v0r 140 14 of of IN cord-262511-96xp1v0r 140 15 the the DT cord-262511-96xp1v0r 140 16 PI-3K PI-3K NNP cord-262511-96xp1v0r 140 17 - - HYPH cord-262511-96xp1v0r 140 18 dependent dependent JJ cord-262511-96xp1v0r 140 19 induction induction NN cord-262511-96xp1v0r 140 20 of of IN cord-262511-96xp1v0r 140 21 the the DT cord-262511-96xp1v0r 140 22 IL-2 IL-2 NNP cord-262511-96xp1v0r 140 23 promoter promoter NN cord-262511-96xp1v0r 140 24 [ [ -LRB- cord-262511-96xp1v0r 140 25 77 77 CD cord-262511-96xp1v0r 140 26 , , , cord-262511-96xp1v0r 140 27 78 78 CD cord-262511-96xp1v0r 140 28 ] ] -RRB- cord-262511-96xp1v0r 140 29 . . . cord-262511-96xp1v0r 141 1 Unlike unlike IN cord-262511-96xp1v0r 141 2 IL-2 IL-2 NNP cord-262511-96xp1v0r 141 3 transcription transcription NN cord-262511-96xp1v0r 141 4 , , , cord-262511-96xp1v0r 141 5 CD28-induced cd28-induce VBN cord-262511-96xp1v0r 141 6 stabilization stabilization NN cord-262511-96xp1v0r 141 7 of of IN cord-262511-96xp1v0r 141 8 the the DT cord-262511-96xp1v0r 141 9 IL-2 IL-2 NNP cord-262511-96xp1v0r 141 10 mRNA mRNA NNP cord-262511-96xp1v0r 142 1 and and CC cord-262511-96xp1v0r 142 2 possibly possibly RB cord-262511-96xp1v0r 142 3 other other JJ cord-262511-96xp1v0r 142 4 cytokine cytokine NN cord-262511-96xp1v0r 143 1 mRNAs mRNAs NNP cord-262511-96xp1v0r 143 2 does do VBZ cord-262511-96xp1v0r 143 3 not not RB cord-262511-96xp1v0r 143 4 require require VB cord-262511-96xp1v0r 143 5 membrane membrane NN cord-262511-96xp1v0r 143 6 colocalization colocalization NN cord-262511-96xp1v0r 143 7 with with IN cord-262511-96xp1v0r 143 8 the the DT cord-262511-96xp1v0r 143 9 TcR tcr NN cord-262511-96xp1v0r 143 10 within within IN cord-262511-96xp1v0r 143 11 CD28 CD28 NNP cord-262511-96xp1v0r 143 12 in in IN cord-262511-96xp1v0r 143 13 a a DT cord-262511-96xp1v0r 143 14 multimolecular multimolecular JJ cord-262511-96xp1v0r 143 15 signaling signal VBG cord-262511-96xp1v0r 143 16 complex complex NN cord-262511-96xp1v0r 143 17 , , , cord-262511-96xp1v0r 143 18 the the DT cord-262511-96xp1v0r 143 19 central central NNP cord-262511-96xp1v0r 143 20 supramolecular supramolecular NNP cord-262511-96xp1v0r 143 21 activation activation NN cord-262511-96xp1v0r 143 22 cluster cluster NN cord-262511-96xp1v0r 143 23 [ [ -LRB- cord-262511-96xp1v0r 143 24 72 72 CD cord-262511-96xp1v0r 143 25 , , , cord-262511-96xp1v0r 143 26 77 77 CD cord-262511-96xp1v0r 143 27 ] ] -RRB- cord-262511-96xp1v0r 143 28 . . . cord-262511-96xp1v0r 144 1 The the DT cord-262511-96xp1v0r 144 2 role role NN cord-262511-96xp1v0r 144 3 of of IN cord-262511-96xp1v0r 144 4 TTP TTP NNP cord-262511-96xp1v0r 144 5 in in IN cord-262511-96xp1v0r 144 6 IL-2 il-2 NN cord-262511-96xp1v0r 144 7 production production NN cord-262511-96xp1v0r 144 8 during during IN cord-262511-96xp1v0r 144 9 T T NNP cord-262511-96xp1v0r 144 10 cell cell NN cord-262511-96xp1v0r 144 11 activation activation NN cord-262511-96xp1v0r 144 12 has have VBZ cord-262511-96xp1v0r 144 13 been be VBN cord-262511-96xp1v0r 144 14 studied study VBN cord-262511-96xp1v0r 144 15 in in IN cord-262511-96xp1v0r 144 16 detail detail NN cord-262511-96xp1v0r 144 17 [ [ -LRB- cord-262511-96xp1v0r 144 18 79 79 CD cord-262511-96xp1v0r 144 19 ] ] -RRB- cord-262511-96xp1v0r 144 20 . . . cord-262511-96xp1v0r 145 1 The the DT cord-262511-96xp1v0r 145 2 TcR/ tcr/ CD cord-262511-96xp1v0r 145 3 CD28-engaged cd28-engaged CD cord-262511-96xp1v0r 145 4 or or CC cord-262511-96xp1v0r 145 5 -immobilized -immobilized JJ cord-262511-96xp1v0r 145 6 , , , cord-262511-96xp1v0r 145 7 anti anti JJ cord-262511-96xp1v0r 145 8 - - JJ cord-262511-96xp1v0r 145 9 CD3-induced cd3-induced JJ cord-262511-96xp1v0r 145 10 T T NNP cord-262511-96xp1v0r 145 11 cells cell NNS cord-262511-96xp1v0r 145 12 derived derive VBN cord-262511-96xp1v0r 145 13 from from IN cord-262511-96xp1v0r 145 14 TTP TTP NNP cord-262511-96xp1v0r 145 15 knockout knockout NN cord-262511-96xp1v0r 145 16 mice mouse NNS cord-262511-96xp1v0r 145 17 have have VBP cord-262511-96xp1v0r 145 18 elevated elevate VBN cord-262511-96xp1v0r 145 19 IL-2 il-2 NN cord-262511-96xp1v0r 145 20 levels level NNS cord-262511-96xp1v0r 145 21 as as IN cord-262511-96xp1v0r 145 22 a a DT cord-262511-96xp1v0r 145 23 result result NN cord-262511-96xp1v0r 145 24 of of IN cord-262511-96xp1v0r 145 25 increased increase VBN cord-262511-96xp1v0r 145 26 stabilization stabilization NN cord-262511-96xp1v0r 145 27 of of IN cord-262511-96xp1v0r 145 28 the the DT cord-262511-96xp1v0r 145 29 IL-2 IL-2 NNP cord-262511-96xp1v0r 145 30 mRNA mRNA NNP cord-262511-96xp1v0r 145 31 [ [ -LRB- cord-262511-96xp1v0r 145 32 79 79 CD cord-262511-96xp1v0r 145 33 ] ] -RRB- cord-262511-96xp1v0r 145 34 . . . cord-262511-96xp1v0r 146 1 TTP TTP NNP cord-262511-96xp1v0r 146 2 is be VBZ cord-262511-96xp1v0r 146 3 able able JJ cord-262511-96xp1v0r 146 4 to to TO cord-262511-96xp1v0r 146 5 bind bind VB cord-262511-96xp1v0r 146 6 32-base 32-base CD cord-262511-96xp1v0r 146 7 AREs are NNS cord-262511-96xp1v0r 146 8 from from IN cord-262511-96xp1v0r 146 9 the the DT cord-262511-96xp1v0r 146 10 IL-2 IL-2 NNP cord-262511-96xp1v0r 146 11 3ЈUTR 3ЈUTR NNP cord-262511-96xp1v0r 146 12 and and CC cord-262511-96xp1v0r 146 13 destabilizes destabilize VBZ cord-262511-96xp1v0r 146 14 reporter reporter NN cord-262511-96xp1v0r 146 15 mRNA mrna NN cord-262511-96xp1v0r 146 16 fused fuse VBD cord-262511-96xp1v0r 146 17 with with IN cord-262511-96xp1v0r 146 18 a a DT cord-262511-96xp1v0r 146 19 3ЈUTR 3јutr CD cord-262511-96xp1v0r 146 20 , , , cord-262511-96xp1v0r 146 21 which which WDT cord-262511-96xp1v0r 146 22 contains contain VBZ cord-262511-96xp1v0r 146 23 the the DT cord-262511-96xp1v0r 146 24 IL-2 IL-2 NNP cord-262511-96xp1v0r 146 25 ARE are VBP cord-262511-96xp1v0r 146 26 [ [ -LRB- cord-262511-96xp1v0r 146 27 79 79 CD cord-262511-96xp1v0r 146 28 ] ] -RRB- cord-262511-96xp1v0r 146 29 . . . cord-262511-96xp1v0r 147 1 Like like IN cord-262511-96xp1v0r 147 2 CD28 CD28 NNP cord-262511-96xp1v0r 147 3 , , , cord-262511-96xp1v0r 147 4 when when WRB cord-262511-96xp1v0r 147 5 LFA-1 LFA-1 NNP cord-262511-96xp1v0r 147 6 on on IN cord-262511-96xp1v0r 147 7 T T NNP cord-262511-96xp1v0r 147 8 cells cell NNS cord-262511-96xp1v0r 147 9 binds bind VBZ cord-262511-96xp1v0r 147 10 to to IN cord-262511-96xp1v0r 147 11 ICAM-1 icam-1 NN cord-262511-96xp1v0r 147 12 on on IN cord-262511-96xp1v0r 147 13 APCs apc NNS cord-262511-96xp1v0r 147 14 , , , cord-262511-96xp1v0r 147 15 allowing allow VBG cord-262511-96xp1v0r 147 16 strong strong JJ cord-262511-96xp1v0r 147 17 adhesion adhesion NN cord-262511-96xp1v0r 147 18 between between IN cord-262511-96xp1v0r 147 19 the the DT cord-262511-96xp1v0r 147 20 two two CD cord-262511-96xp1v0r 147 21 cells cell NNS cord-262511-96xp1v0r 147 22 and and CC cord-262511-96xp1v0r 147 23 promoting promote VBG cord-262511-96xp1v0r 147 24 efficient efficient JJ cord-262511-96xp1v0r 147 25 T T NNP cord-262511-96xp1v0r 147 26 cell cell NN cord-262511-96xp1v0r 147 27 activation activation NN cord-262511-96xp1v0r 147 28 [ [ -LRB- cord-262511-96xp1v0r 147 29 80 80 CD cord-262511-96xp1v0r 147 30 ] ] -RRB- cord-262511-96xp1v0r 147 31 , , , cord-262511-96xp1v0r 147 32 it -PRON- PRP cord-262511-96xp1v0r 147 33 stabilizes stabilize VBZ cord-262511-96xp1v0r 147 34 certain certain JJ cord-262511-96xp1v0r 147 35 cytokine cytokine NN cord-262511-96xp1v0r 147 36 mRNAs mrnas CD cord-262511-96xp1v0r 147 37 [ [ -LRB- cord-262511-96xp1v0r 147 38 81 81 CD cord-262511-96xp1v0r 147 39 ] ] -RRB- cord-262511-96xp1v0r 147 40 . . . cord-262511-96xp1v0r 148 1 Although although IN cord-262511-96xp1v0r 148 2 it -PRON- PRP cord-262511-96xp1v0r 148 3 has have VBZ cord-262511-96xp1v0r 148 4 been be VBN cord-262511-96xp1v0r 148 5 reported report VBN cord-262511-96xp1v0r 148 6 that that IN cord-262511-96xp1v0r 148 7 HuR hur NN cord-262511-96xp1v0r 148 8 translocation translocation NN cord-262511-96xp1v0r 148 9 occurs occur VBZ cord-262511-96xp1v0r 148 10 in in IN cord-262511-96xp1v0r 148 11 mouse mouse NN cord-262511-96xp1v0r 148 12 T T NNP cord-262511-96xp1v0r 148 13 cells cell NNS cord-262511-96xp1v0r 148 14 upon upon IN cord-262511-96xp1v0r 148 15 CD28-induced cd28-induce VBN cord-262511-96xp1v0r 148 16 signaling signaling NN cord-262511-96xp1v0r 148 17 , , , cord-262511-96xp1v0r 148 18 without without IN cord-262511-96xp1v0r 148 19 an an DT cord-262511-96xp1v0r 148 20 effect effect NN cord-262511-96xp1v0r 148 21 on on IN cord-262511-96xp1v0r 148 22 IL-2 IL-2 NNP cord-262511-96xp1v0r 148 23 mRNA mRNA NNP cord-262511-96xp1v0r 148 24 stabilization stabilization NN cord-262511-96xp1v0r 148 25 [ [ -LRB- cord-262511-96xp1v0r 148 26 82 82 CD cord-262511-96xp1v0r 148 27 ] ] -RRB- cord-262511-96xp1v0r 148 28 , , , cord-262511-96xp1v0r 148 29 LFA-1 LFA-1 NNP cord-262511-96xp1v0r 148 30 or or CC cord-262511-96xp1v0r 148 31 CD28 CD28 NNP cord-262511-96xp1v0r 148 32 engagement engagement NN cord-262511-96xp1v0r 148 33 of of IN cord-262511-96xp1v0r 148 34 human human NN cord-262511-96xp1v0r 148 35 - - HYPH cord-262511-96xp1v0r 148 36 stimulated stimulate VBN cord-262511-96xp1v0r 148 37 T t NN cord-262511-96xp1v0r 148 38 cells cell NNS cord-262511-96xp1v0r 148 39 promoted promote VBD cord-262511-96xp1v0r 148 40 HuR hur NN cord-262511-96xp1v0r 148 41 translocation translocation NN cord-262511-96xp1v0r 148 42 to to IN cord-262511-96xp1v0r 148 43 the the DT cord-262511-96xp1v0r 148 44 cytoplasm cytoplasm NN cord-262511-96xp1v0r 148 45 and and CC cord-262511-96xp1v0r 148 46 stabilized stabilize VBD cord-262511-96xp1v0r 148 47 TNF- TNF- NNP cord-262511-96xp1v0r 148 48 ␣ ␣ NN cord-262511-96xp1v0r 148 49 and and CC cord-262511-96xp1v0r 148 50 GM GM NNP cord-262511-96xp1v0r 148 51 - - HYPH cord-262511-96xp1v0r 148 52 CSF CSF NNP cord-262511-96xp1v0r 148 53 [ [ -LRB- cord-262511-96xp1v0r 148 54 81 81 CD cord-262511-96xp1v0r 148 55 ] ] -RRB- cord-262511-96xp1v0r 148 56 . . . cord-262511-96xp1v0r 149 1 This this DT cord-262511-96xp1v0r 149 2 discrepancy discrepancy NN cord-262511-96xp1v0r 149 3 may may MD cord-262511-96xp1v0r 149 4 be be VB cord-262511-96xp1v0r 149 5 a a DT cord-262511-96xp1v0r 149 6 result result NN cord-262511-96xp1v0r 149 7 of of IN cord-262511-96xp1v0r 149 8 the the DT cord-262511-96xp1v0r 149 9 species specie NNS cord-262511-96xp1v0r 149 10 source source NN cord-262511-96xp1v0r 149 11 of of IN cord-262511-96xp1v0r 149 12 the the DT cord-262511-96xp1v0r 149 13 lymphocytes lymphocyte NNS cord-262511-96xp1v0r 149 14 used use VBN cord-262511-96xp1v0r 149 15 in in IN cord-262511-96xp1v0r 149 16 the the DT cord-262511-96xp1v0r 149 17 two two CD cord-262511-96xp1v0r 149 18 studies study NNS cord-262511-96xp1v0r 149 19 . . . cord-262511-96xp1v0r 150 1 AREs AREs NNP cord-262511-96xp1v0r 150 2 are be VBP cord-262511-96xp1v0r 150 3 evolutionally evolutionally RB cord-262511-96xp1v0r 150 4 conserved conserve VBN cord-262511-96xp1v0r 150 5 in in IN cord-262511-96xp1v0r 150 6 mammalian mammalian JJ cord-262511-96xp1v0r 150 7 , , , cord-262511-96xp1v0r 150 8 but but CC cord-262511-96xp1v0r 150 9 the the DT cord-262511-96xp1v0r 150 10 numbers number NNS cord-262511-96xp1v0r 150 11 of of IN cord-262511-96xp1v0r 150 12 ARE are VBP cord-262511-96xp1v0r 150 13 pentamers pentamer NNS cord-262511-96xp1v0r 150 14 may may MD cord-262511-96xp1v0r 150 15 differ differ VB cord-262511-96xp1v0r 150 16 slightly slightly RB cord-262511-96xp1v0r 150 17 among among IN cord-262511-96xp1v0r 150 18 species specie NNS cord-262511-96xp1v0r 150 19 , , , cord-262511-96xp1v0r 150 20 allowing allow VBG cord-262511-96xp1v0r 150 21 differential differential JJ cord-262511-96xp1v0r 150 22 responses response NNS cord-262511-96xp1v0r 150 23 [ [ -LRB- cord-262511-96xp1v0r 150 24 70 70 CD cord-262511-96xp1v0r 150 25 ] ] -RRB- cord-262511-96xp1v0r 150 26 . . . cord-262511-96xp1v0r 151 1 A a DT cord-262511-96xp1v0r 151 2 novel novel JJ cord-262511-96xp1v0r 151 3 pathway pathway NN cord-262511-96xp1v0r 151 4 in in IN cord-262511-96xp1v0r 151 5 cytokine cytokine NN cord-262511-96xp1v0r 151 6 mRNA mrna NN cord-262511-96xp1v0r 151 7 stabilization stabilization NN cord-262511-96xp1v0r 151 8 in in IN cord-262511-96xp1v0r 151 9 T T NNP cord-262511-96xp1v0r 151 10 cell cell NN cord-262511-96xp1v0r 151 11 activation activation NN cord-262511-96xp1v0r 151 12 and and CC cord-262511-96xp1v0r 151 13 differentiation differentiation NN cord-262511-96xp1v0r 151 14 , , , cord-262511-96xp1v0r 151 15 also also RB cord-262511-96xp1v0r 151 16 occurring occur VBG cord-262511-96xp1v0r 151 17 during during IN cord-262511-96xp1v0r 151 18 eosinophils eosinophils NN cord-262511-96xp1v0r 151 19 activation activation NN cord-262511-96xp1v0r 151 20 , , , cord-262511-96xp1v0r 151 21 has have VBZ cord-262511-96xp1v0r 151 22 been be VBN cord-262511-96xp1v0r 151 23 described describe VBN cord-262511-96xp1v0r 151 24 recently recently RB cord-262511-96xp1v0r 151 25 involving involve VBG cord-262511-96xp1v0r 151 26 pin1 pin1 NNP cord-262511-96xp1v0r 151 27 [ [ -LRB- cord-262511-96xp1v0r 151 28 83 83 CD cord-262511-96xp1v0r 151 29 , , , cord-262511-96xp1v0r 151 30 84 84 CD cord-262511-96xp1v0r 151 31 ] ] -RRB- cord-262511-96xp1v0r 151 32 . . . cord-262511-96xp1v0r 152 1 This this DT cord-262511-96xp1v0r 152 2 protein protein NN cord-262511-96xp1v0r 152 3 isomerizes isomerizes POS cord-262511-96xp1v0r 152 4 specific specific JJ cord-262511-96xp1v0r 152 5 peptide peptide NN cord-262511-96xp1v0r 152 6 bonds bond NNS cord-262511-96xp1v0r 152 7 and and CC cord-262511-96xp1v0r 152 8 thus thus RB cord-262511-96xp1v0r 152 9 , , , cord-262511-96xp1v0r 152 10 alters alter VBZ cord-262511-96xp1v0r 152 11 protein protein NN cord-262511-96xp1v0r 152 12 folding folding NN cord-262511-96xp1v0r 152 13 and and CC cord-262511-96xp1v0r 152 14 activity activity NN cord-262511-96xp1v0r 152 15 ; ; : cord-262511-96xp1v0r 152 16 when when WRB cord-262511-96xp1v0r 152 17 it -PRON- PRP cord-262511-96xp1v0r 152 18 becomes become VBZ cord-262511-96xp1v0r 152 19 activated activate VBN cord-262511-96xp1v0r 152 20 in in IN cord-262511-96xp1v0r 152 21 TcR/ tcr/ ADD cord-262511-96xp1v0r 153 1 CD28-stimulated cd28-stimulated JJ cord-262511-96xp1v0r 153 2 CD4 CD4 NNP cord-262511-96xp1v0r 153 3 T T NNP cord-262511-96xp1v0r 153 4 cells cell NNS cord-262511-96xp1v0r 153 5 , , , cord-262511-96xp1v0r 153 6 it -PRON- PRP cord-262511-96xp1v0r 153 7 associates associate VBZ cord-262511-96xp1v0r 153 8 concurrently concurrently RB cord-262511-96xp1v0r 153 9 with with IN cord-262511-96xp1v0r 153 10 AUF1 AUF1 NNP cord-262511-96xp1v0r 154 1 and and CC cord-262511-96xp1v0r 154 2 HuR. HuR. NNP cord-262511-96xp1v0r 154 3 This this DT cord-262511-96xp1v0r 154 4 results result VBZ cord-262511-96xp1v0r 154 5 in in IN cord-262511-96xp1v0r 154 6 stabilization stabilization NN cord-262511-96xp1v0r 154 7 of of IN cord-262511-96xp1v0r 154 8 GM GM NNP cord-262511-96xp1v0r 154 9 - - HYPH cord-262511-96xp1v0r 154 10 CSF CSF NNP cord-262511-96xp1v0r 154 11 mRNA mrna NN cord-262511-96xp1v0r 154 12 as as IN cord-262511-96xp1v0r 154 13 a a DT cord-262511-96xp1v0r 154 14 result result NN cord-262511-96xp1v0r 154 15 of of IN cord-262511-96xp1v0r 154 16 the the DT cord-262511-96xp1v0r 154 17 loss loss NN cord-262511-96xp1v0r 154 18 of of IN cord-262511-96xp1v0r 154 19 the the DT cord-262511-96xp1v0r 154 20 mRNA mRNA NNP cord-262511-96xp1v0r 154 21 decay decay NN cord-262511-96xp1v0r 154 22 - - HYPH cord-262511-96xp1v0r 154 23 promoting promote VBG cord-262511-96xp1v0r 154 24 activity activity NN cord-262511-96xp1v0r 154 25 of of IN cord-262511-96xp1v0r 154 26 AUF1 AUF1 NNP cord-262511-96xp1v0r 154 27 , , , cord-262511-96xp1v0r 154 28 which which WDT cord-262511-96xp1v0r 154 29 is be VBZ cord-262511-96xp1v0r 154 30 linked link VBN cord-262511-96xp1v0r 154 31 to to IN cord-262511-96xp1v0r 154 32 the the DT cord-262511-96xp1v0r 154 33 exosome exosome NN cord-262511-96xp1v0r 154 34 ( ( -LRB- cord-262511-96xp1v0r 154 35 Fig fig NN cord-262511-96xp1v0r 154 36 . . NNP cord-262511-96xp1v0r 154 37 2 2 CD cord-262511-96xp1v0r 154 38 ) ) -RRB- cord-262511-96xp1v0r 154 39 . . . cord-262511-96xp1v0r 155 1 AUF1 AUF1 NNP cord-262511-96xp1v0r 155 2 may may MD cord-262511-96xp1v0r 155 3 be be VB cord-262511-96xp1v0r 155 4 isomerized isomerize VBN cord-262511-96xp1v0r 155 5 by by IN cord-262511-96xp1v0r 155 6 pin1 pin1 NNP cord-262511-96xp1v0r 155 7 , , , cord-262511-96xp1v0r 155 8 allowing allow VBG cord-262511-96xp1v0r 155 9 the the DT cord-262511-96xp1v0r 155 10 stabilizing stabilize VBG cord-262511-96xp1v0r 155 11 action action NN cord-262511-96xp1v0r 155 12 of of IN cord-262511-96xp1v0r 155 13 HuR hur NN cord-262511-96xp1v0r 155 14 to to TO cord-262511-96xp1v0r 155 15 predominate predominate VB cord-262511-96xp1v0r 155 16 [ [ -LRB- cord-262511-96xp1v0r 155 17 83 83 CD cord-262511-96xp1v0r 155 18 ] ] -RRB- cord-262511-96xp1v0r 155 19 . . . cord-262511-96xp1v0r 156 1 AUF1 AUF1 NNP cord-262511-96xp1v0r 156 2 is be VBZ cord-262511-96xp1v0r 156 3 a a DT cord-262511-96xp1v0r 156 4 nucleocytoplasmic nucleocytoplasmic NN cord-262511-96xp1v0r 156 5 - - HYPH cord-262511-96xp1v0r 156 6 shuttling shuttle VBG cord-262511-96xp1v0r 156 7 protein protein NN cord-262511-96xp1v0r 156 8 and and CC cord-262511-96xp1v0r 156 9 is be VBZ cord-262511-96xp1v0r 156 10 associated associate VBN cord-262511-96xp1v0r 156 11 with with IN cord-262511-96xp1v0r 156 12 stabilization stabilization NN cord-262511-96xp1v0r 156 13 and and CC cord-262511-96xp1v0r 156 14 destabilization destabilization NN cord-262511-96xp1v0r 156 15 activities activity NNS cord-262511-96xp1v0r 156 16 ; ; : cord-262511-96xp1v0r 156 17 this this DT cord-262511-96xp1v0r 156 18 appears appear VBZ cord-262511-96xp1v0r 156 19 to to TO cord-262511-96xp1v0r 156 20 be be VB cord-262511-96xp1v0r 156 21 dependent dependent JJ cord-262511-96xp1v0r 156 22 on on IN cord-262511-96xp1v0r 156 23 the the DT cord-262511-96xp1v0r 156 24 AUF1 AUF1 NNP cord-262511-96xp1v0r 156 25 isoform isoform NN cord-262511-96xp1v0r 156 26 generated generate VBN cord-262511-96xp1v0r 156 27 from from IN cord-262511-96xp1v0r 156 28 four four CD cord-262511-96xp1v0r 156 29 alternative alternative NN cord-262511-96xp1v0r 156 30 - - HYPH cord-262511-96xp1v0r 156 31 spliced spliced JJ cord-262511-96xp1v0r 156 32 mRNAs mrna NNS cord-262511-96xp1v0r 156 33 and and CC cord-262511-96xp1v0r 156 34 the the DT cord-262511-96xp1v0r 156 35 cell cell NN cord-262511-96xp1v0r 156 36 type type NN cord-262511-96xp1v0r 156 37 in in IN cord-262511-96xp1v0r 156 38 question question NN cord-262511-96xp1v0r 156 39 . . . cord-262511-96xp1v0r 157 1 For for IN cord-262511-96xp1v0r 157 2 example example NN cord-262511-96xp1v0r 157 3 , , , cord-262511-96xp1v0r 157 4 when when WRB cord-262511-96xp1v0r 157 5 AUF1 AUF1 NNP cord-262511-96xp1v0r 157 6 p37 p37 CD cord-262511-96xp1v0r 157 7 and and CC cord-262511-96xp1v0r 157 8 p42 p42 CD cord-262511-96xp1v0r 157 9 isoforms isoform NNS cord-262511-96xp1v0r 157 10 are be VBP cord-262511-96xp1v0r 157 11 overexpressed overexpresse VBN cord-262511-96xp1v0r 157 12 , , , cord-262511-96xp1v0r 157 13 they -PRON- PRP cord-262511-96xp1v0r 157 14 bind bind VBP cord-262511-96xp1v0r 157 15 to to IN cord-262511-96xp1v0r 157 16 IL-6 IL-6 NNP cord-262511-96xp1v0r 157 17 3ЈUTR 3ЈUTR NNP cord-262511-96xp1v0r 157 18 , , , cord-262511-96xp1v0r 157 19 facilitated facilitate VBN cord-262511-96xp1v0r 157 20 by by IN cord-262511-96xp1v0r 157 21 a a DT cord-262511-96xp1v0r 157 22 putative putative JJ cord-262511-96xp1v0r 157 23 RNA RNA NNP cord-262511-96xp1v0r 157 24 stem stem NN cord-262511-96xp1v0r 157 25 - - HYPH cord-262511-96xp1v0r 157 26 loop loop NN cord-262511-96xp1v0r 157 27 structure structure NN cord-262511-96xp1v0r 157 28 ; ; : cord-262511-96xp1v0r 157 29 this this DT cord-262511-96xp1v0r 157 30 process process NN cord-262511-96xp1v0r 157 31 promotes promote VBZ cord-262511-96xp1v0r 157 32 the the DT cord-262511-96xp1v0r 157 33 stabilization stabilization NN cord-262511-96xp1v0r 157 34 of of IN cord-262511-96xp1v0r 157 35 IL-6 IL-6 NNP cord-262511-96xp1v0r 157 36 mRNA mRNA NNP cord-262511-96xp1v0r 157 37 [ [ -LRB- cord-262511-96xp1v0r 157 38 85 85 CD cord-262511-96xp1v0r 157 39 ] ] -RRB- cord-262511-96xp1v0r 157 40 . . . cord-262511-96xp1v0r 158 1 TTP TTP NNP cord-262511-96xp1v0r 158 2 plays play VBZ cord-262511-96xp1v0r 158 3 a a DT cord-262511-96xp1v0r 158 4 significant significant JJ cord-262511-96xp1v0r 158 5 role role NN cord-262511-96xp1v0r 158 6 in in IN cord-262511-96xp1v0r 158 7 regulating regulate VBG cord-262511-96xp1v0r 158 8 mRNA mrna NN cord-262511-96xp1v0r 158 9 stability stability NN cord-262511-96xp1v0r 158 10 of of IN cord-262511-96xp1v0r 158 11 cytokines cytokine NNS cord-262511-96xp1v0r 158 12 such such JJ cord-262511-96xp1v0r 158 13 as as IN cord-262511-96xp1v0r 158 14 IL-2 IL-2 NNP cord-262511-96xp1v0r 158 15 during during IN cord-262511-96xp1v0r 158 16 T T NNP cord-262511-96xp1v0r 158 17 cell cell NN cord-262511-96xp1v0r 158 18 activation activation NN cord-262511-96xp1v0r 158 19 . . . cord-262511-96xp1v0r 159 1 Thus thus RB cord-262511-96xp1v0r 159 2 , , , cord-262511-96xp1v0r 159 3 one one PRP cord-262511-96xp1v0r 159 4 can can MD cord-262511-96xp1v0r 159 5 envision envision VB cord-262511-96xp1v0r 159 6 that that IN cord-262511-96xp1v0r 159 7 for for IN cord-262511-96xp1v0r 159 8 CD28-or CD28-or NNP cord-262511-96xp1v0r 159 9 LFA-1-induced lfa-1-induce VBN cord-262511-96xp1v0r 159 10 stabilization stabilization NN cord-262511-96xp1v0r 159 11 to to TO cord-262511-96xp1v0r 159 12 occur occur VB cord-262511-96xp1v0r 159 13 following follow VBG cord-262511-96xp1v0r 159 14 T T NNP cord-262511-96xp1v0r 159 15 cell cell NN cord-262511-96xp1v0r 159 16 activation activation NN cord-262511-96xp1v0r 159 17 , , , cord-262511-96xp1v0r 159 18 TTP TTP NNP cord-262511-96xp1v0r 159 19 destabilization destabilization NN cord-262511-96xp1v0r 159 20 action action NN cord-262511-96xp1v0r 159 21 must must MD cord-262511-96xp1v0r 159 22 cease cease VB cord-262511-96xp1v0r 159 23 . . . cord-262511-96xp1v0r 160 1 This this DT cord-262511-96xp1v0r 160 2 can can MD cord-262511-96xp1v0r 160 3 happen happen VB cord-262511-96xp1v0r 160 4 by by IN cord-262511-96xp1v0r 160 5 either either DT cord-262511-96xp1v0r 160 6 or or CC cord-262511-96xp1v0r 160 7 both both DT cord-262511-96xp1v0r 160 8 of of IN cord-262511-96xp1v0r 160 9 two two CD cord-262511-96xp1v0r 160 10 scenarios scenario NNS cord-262511-96xp1v0r 160 11 : : : cord-262511-96xp1v0r 160 12 coordinated coordinate VBN cord-262511-96xp1v0r 160 13 stabilization stabilization NN cord-262511-96xp1v0r 160 14 - - HYPH cord-262511-96xp1v0r 160 15 destabilization destabilization NN cord-262511-96xp1v0r 160 16 kinetics kinetic NNS cord-262511-96xp1v0r 160 17 and and CC cord-262511-96xp1v0r 160 18 TTP TTP NNP cord-262511-96xp1v0r 160 19 phosphorylation phosphorylation NN cord-262511-96xp1v0r 161 1 ( ( -LRB- cord-262511-96xp1v0r 161 2 Fig Fig NNP cord-262511-96xp1v0r 161 3 . . NNP cord-262511-96xp1v0r 161 4 2 2 CD cord-262511-96xp1v0r 161 5 ) ) -RRB- cord-262511-96xp1v0r 161 6 . . . cord-262511-96xp1v0r 162 1 With with IN cord-262511-96xp1v0r 162 2 the the DT cord-262511-96xp1v0r 162 3 coordinated coordinate VBN cord-262511-96xp1v0r 162 4 kinetics kinetics NN cord-262511-96xp1v0r 162 5 model model NN cord-262511-96xp1v0r 162 6 , , , cord-262511-96xp1v0r 162 7 stabilizing stabilize VBG cord-262511-96xp1v0r 162 8 RNA rna NN cord-262511-96xp1v0r 162 9 - - HYPH cord-262511-96xp1v0r 162 10 binding bind VBG cord-262511-96xp1v0r 162 11 proteins protein NNS cord-262511-96xp1v0r 162 12 such such JJ cord-262511-96xp1v0r 162 13 as as IN cord-262511-96xp1v0r 162 14 HuR hur NN cord-262511-96xp1v0r 162 15 can can MD cord-262511-96xp1v0r 162 16 occur occur VB cord-262511-96xp1v0r 162 17 initially initially RB cord-262511-96xp1v0r 162 18 following follow VBG cord-262511-96xp1v0r 162 19 immune immune JJ cord-262511-96xp1v0r 162 20 cell cell NN cord-262511-96xp1v0r 162 21 activation activation NN cord-262511-96xp1v0r 162 22 , , , cord-262511-96xp1v0r 162 23 allowing allow VBG cord-262511-96xp1v0r 162 24 rapid rapid JJ cord-262511-96xp1v0r 162 25 and and CC cord-262511-96xp1v0r 162 26 early early JJ cord-262511-96xp1v0r 162 27 response response NN cord-262511-96xp1v0r 162 28 of of IN cord-262511-96xp1v0r 162 29 cytokine cytokine NN cord-262511-96xp1v0r 162 30 production production NN cord-262511-96xp1v0r 162 31 . . . cord-262511-96xp1v0r 163 1 This this DT cord-262511-96xp1v0r 163 2 is be VBZ cord-262511-96xp1v0r 163 3 followed follow VBN cord-262511-96xp1v0r 163 4 by by IN cord-262511-96xp1v0r 163 5 the the DT cord-262511-96xp1v0r 163 6 action action NN cord-262511-96xp1v0r 163 7 of of IN cord-262511-96xp1v0r 163 8 mRNA mrna NN cord-262511-96xp1v0r 163 9 - - HYPH cord-262511-96xp1v0r 163 10 destabilizing destabilize VBG cord-262511-96xp1v0r 163 11 proteins protein NNS cord-262511-96xp1v0r 163 12 such such JJ cord-262511-96xp1v0r 163 13 as as IN cord-262511-96xp1v0r 163 14 TTP TTP NNP cord-262511-96xp1v0r 163 15 , , , cord-262511-96xp1v0r 163 16 resulting result VBG cord-262511-96xp1v0r 163 17 in in IN cord-262511-96xp1v0r 163 18 transient transient JJ cord-262511-96xp1v0r 163 19 cytokine cytokine NN cord-262511-96xp1v0r 163 20 production production NN cord-262511-96xp1v0r 163 21 . . . cord-262511-96xp1v0r 164 1 HuR HuR NNP cord-262511-96xp1v0r 164 2 translocation translocation NN cord-262511-96xp1v0r 164 3 following follow VBG cord-262511-96xp1v0r 164 4 TcR TcR NNP cord-262511-96xp1v0r 164 5 / / SYM cord-262511-96xp1v0r 164 6 CD28 CD28 NNP cord-262511-96xp1v0r 164 7 engagement engagement NN cord-262511-96xp1v0r 164 8 is be VBZ cord-262511-96xp1v0r 164 9 seen see VBN cord-262511-96xp1v0r 164 10 , , , cord-262511-96xp1v0r 164 11 first first RB cord-262511-96xp1v0r 164 12 within within IN cord-262511-96xp1v0r 164 13 1 1 CD cord-262511-96xp1v0r 164 14 h h NN cord-262511-96xp1v0r 164 15 , , , cord-262511-96xp1v0r 164 16 and and CC cord-262511-96xp1v0r 164 17 TTP TTP NNP cord-262511-96xp1v0r 164 18 is be VBZ cord-262511-96xp1v0r 164 19 induced induce VBN cord-262511-96xp1v0r 164 20 in in IN cord-262511-96xp1v0r 164 21 activated activate VBN cord-262511-96xp1v0r 164 22 T T NNP cord-262511-96xp1v0r 164 23 cells cell NNS cord-262511-96xp1v0r 164 24 in in IN cord-262511-96xp1v0r 164 25 a a DT cord-262511-96xp1v0r 164 26 later later JJ cord-262511-96xp1v0r 164 27 time time NN cord-262511-96xp1v0r 164 28 [ [ -LRB- cord-262511-96xp1v0r 164 29 86 86 CD cord-262511-96xp1v0r 164 30 ] ] -RRB- cord-262511-96xp1v0r 164 31 . . . cord-262511-96xp1v0r 165 1 There there EX cord-262511-96xp1v0r 165 2 is be VBZ cord-262511-96xp1v0r 165 3 also also RB cord-262511-96xp1v0r 165 4 the the DT cord-262511-96xp1v0r 165 5 potential potential NN cord-262511-96xp1v0r 165 6 for for IN cord-262511-96xp1v0r 165 7 interesting interesting JJ cord-262511-96xp1v0r 165 8 reciprocal reciprocal JJ cord-262511-96xp1v0r 165 9 regulation regulation NN cord-262511-96xp1v0r 165 10 , , , cord-262511-96xp1v0r 165 11 which which WDT cord-262511-96xp1v0r 165 12 helps help VBZ cord-262511-96xp1v0r 165 13 to to TO cord-262511-96xp1v0r 165 14 amplify amplify VB cord-262511-96xp1v0r 165 15 this this DT cord-262511-96xp1v0r 165 16 " " `` cord-262511-96xp1v0r 165 17 cycle cycle NN cord-262511-96xp1v0r 165 18 " " '' cord-262511-96xp1v0r 165 19 ; ; : cord-262511-96xp1v0r 165 20 HuR HuR NNP cord-262511-96xp1v0r 165 21 may may MD cord-262511-96xp1v0r 165 22 stabilize stabilize VB cord-262511-96xp1v0r 165 23 TTP TTP NNP cord-262511-96xp1v0r 165 24 mRNA mrna NN cord-262511-96xp1v0r 165 25 itself -PRON- PRP cord-262511-96xp1v0r 165 26 , , , cord-262511-96xp1v0r 165 27 thus thus RB cord-262511-96xp1v0r 165 28 helping help VBG cord-262511-96xp1v0r 165 29 to to IN cord-262511-96xp1v0r 165 30 prime prime JJ cord-262511-96xp1v0r 165 31 TTP TTP NNP cord-262511-96xp1v0r 165 32 for for IN cord-262511-96xp1v0r 165 33 its -PRON- PRP$ cord-262511-96xp1v0r 165 34 destabilizing destabilizing JJ cord-262511-96xp1v0r 165 35 action action NN cord-262511-96xp1v0r 165 36 on on IN cord-262511-96xp1v0r 165 37 cytokine cytokine NN cord-262511-96xp1v0r 165 38 mRNAs mrnas CD cord-262511-96xp1v0r 165 39 . . . cord-262511-96xp1v0r 166 1 TTP TTP NNP cord-262511-96xp1v0r 166 2 has have VBZ cord-262511-96xp1v0r 166 3 also also RB cord-262511-96xp1v0r 166 4 been be VBN cord-262511-96xp1v0r 166 5 suggested suggest VBN cord-262511-96xp1v0r 166 6 to to TO cord-262511-96xp1v0r 166 7 regulate regulate VB cord-262511-96xp1v0r 166 8 the the DT cord-262511-96xp1v0r 166 9 stability stability NN cord-262511-96xp1v0r 166 10 of of IN cord-262511-96xp1v0r 166 11 its -PRON- PRP$ cord-262511-96xp1v0r 166 12 own own JJ cord-262511-96xp1v0r 166 13 mRNA mrna NN cord-262511-96xp1v0r 166 14 in in IN cord-262511-96xp1v0r 166 15 different different JJ cord-262511-96xp1v0r 166 16 cell cell NN cord-262511-96xp1v0r 166 17 types type NNS cord-262511-96xp1v0r 166 18 [ [ -LRB- cord-262511-96xp1v0r 166 19 20 20 CD cord-262511-96xp1v0r 166 20 , , , cord-262511-96xp1v0r 166 21 21 21 CD cord-262511-96xp1v0r 166 22 ] ] -RRB- cord-262511-96xp1v0r 166 23 , , , cord-262511-96xp1v0r 166 24 although although IN cord-262511-96xp1v0r 166 25 this this DT cord-262511-96xp1v0r 166 26 has have VBZ cord-262511-96xp1v0r 166 27 not not RB cord-262511-96xp1v0r 166 28 been be VBN cord-262511-96xp1v0r 166 29 proved prove VBN cord-262511-96xp1v0r 166 30 conclusively conclusively RB cord-262511-96xp1v0r 166 31 [ [ -LRB- cord-262511-96xp1v0r 166 32 4 4 CD cord-262511-96xp1v0r 166 33 ] ] -RRB- cord-262511-96xp1v0r 166 34 ; ; : cord-262511-96xp1v0r 166 35 it -PRON- PRP cord-262511-96xp1v0r 166 36 is be VBZ cord-262511-96xp1v0r 166 37 also also RB cord-262511-96xp1v0r 166 38 possible possible JJ cord-262511-96xp1v0r 166 39 that that IN cord-262511-96xp1v0r 166 40 this this DT cord-262511-96xp1v0r 166 41 regulation regulation NN cord-262511-96xp1v0r 166 42 extends extend VBZ cord-262511-96xp1v0r 166 43 to to IN cord-262511-96xp1v0r 166 44 activated activate VBN cord-262511-96xp1v0r 166 45 T t NN cord-262511-96xp1v0r 166 46 cells cell NNS cord-262511-96xp1v0r 166 47 . . . cord-262511-96xp1v0r 167 1 The the DT cord-262511-96xp1v0r 167 2 second second JJ cord-262511-96xp1v0r 167 3 scenario scenario NN cord-262511-96xp1v0r 167 4 is be VBZ cord-262511-96xp1v0r 167 5 that that IN cord-262511-96xp1v0r 167 6 TTP TTP NNP cord-262511-96xp1v0r 167 7 becomes become VBZ cord-262511-96xp1v0r 167 8 transiently transiently RB cord-262511-96xp1v0r 167 9 phosphorylated phosphorylate VBN cord-262511-96xp1v0r 167 10 by by IN cord-262511-96xp1v0r 167 11 one one CD cord-262511-96xp1v0r 167 12 of of IN cord-262511-96xp1v0r 167 13 the the DT cord-262511-96xp1v0r 167 14 kinases kinase NNS cord-262511-96xp1v0r 167 15 following follow VBG cord-262511-96xp1v0r 167 16 CD28 CD28 NNP cord-262511-96xp1v0r 167 17 or or CC cord-262511-96xp1v0r 167 18 LFA-1 LFA-1 NNP cord-262511-96xp1v0r 167 19 engagement engagement NN cord-262511-96xp1v0r 167 20 . . . cord-262511-96xp1v0r 168 1 The the DT cord-262511-96xp1v0r 168 2 ultimate ultimate JJ cord-262511-96xp1v0r 168 3 outcome outcome NN cord-262511-96xp1v0r 168 4 is be VBZ cord-262511-96xp1v0r 168 5 a a DT cord-262511-96xp1v0r 168 6 transient transient JJ cord-262511-96xp1v0r 168 7 immune immune JJ cord-262511-96xp1v0r 168 8 response response NN cord-262511-96xp1v0r 168 9 and and CC cord-262511-96xp1v0r 168 10 controlled control VBN cord-262511-96xp1v0r 168 11 cytokine cytokine NN cord-262511-96xp1v0r 168 12 production production NN cord-262511-96xp1v0r 168 13 . . . cord-262511-96xp1v0r 169 1 During during IN cord-262511-96xp1v0r 169 2 restimulation restimulation NN cord-262511-96xp1v0r 169 3 of of IN cord-262511-96xp1v0r 169 4 Th2 th2 CD cord-262511-96xp1v0r 169 5 cells cell NNS cord-262511-96xp1v0r 169 6 , , , cord-262511-96xp1v0r 169 7 as as IN cord-262511-96xp1v0r 169 8 opposed oppose VBN cord-262511-96xp1v0r 169 9 to to IN cord-262511-96xp1v0r 169 10 priming prime VBG cord-262511-96xp1v0r 169 11 of of IN cord-262511-96xp1v0r 169 12 naïve naïve JJ cord-262511-96xp1v0r 169 13 T t NN cord-262511-96xp1v0r 169 14 cells cell NNS cord-262511-96xp1v0r 169 15 with with IN cord-262511-96xp1v0r 169 16 APC APC NNP cord-262511-96xp1v0r 169 17 , , , cord-262511-96xp1v0r 169 18 rapid rapid JJ cord-262511-96xp1v0r 169 19 dephosphorylation dephosphorylation NN cord-262511-96xp1v0r 169 20 of of IN cord-262511-96xp1v0r 170 1 eIF2 eIF2 NNP cord-262511-96xp1v0r 170 2 ␣ ␣ NNP cord-262511-96xp1v0r 170 3 occurs occur VBZ cord-262511-96xp1v0r 170 4 and and CC cord-262511-96xp1v0r 170 5 results result VBZ cord-262511-96xp1v0r 170 6 in in IN cord-262511-96xp1v0r 170 7 derepression derepression NN cord-262511-96xp1v0r 170 8 of of IN cord-262511-96xp1v0r 170 9 translational translational JJ cord-262511-96xp1v0r 170 10 arrest arrest NN cord-262511-96xp1v0r 170 11 of of IN cord-262511-96xp1v0r 170 12 cytokine cytokine NN cord-262511-96xp1v0r 170 13 mRNAs mrna NNS cord-262511-96xp1v0r 170 14 such such JJ cord-262511-96xp1v0r 170 15 as as IN cord-262511-96xp1v0r 170 16 IL-4 IL-4 NNP cord-262511-96xp1v0r 170 17 mRNA mRNA NNP cord-262511-96xp1v0r 170 18 [ [ -LRB- cord-262511-96xp1v0r 170 19 87 87 CD cord-262511-96xp1v0r 170 20 ] ] -RRB- cord-262511-96xp1v0r 170 21 . . . cord-262511-96xp1v0r 171 1 This this DT cord-262511-96xp1v0r 171 2 process process NN cord-262511-96xp1v0r 171 3 in- in- XX cord-262511-96xp1v0r 172 1 Fig Fig NNP cord-262511-96xp1v0r 172 2 . . . cord-262511-96xp1v0r 173 1 2 2 LS cord-262511-96xp1v0r 173 2 . . . cord-262511-96xp1v0r 174 1 Enhanced enhanced JJ cord-262511-96xp1v0r 174 2 mRNA mrna NN cord-262511-96xp1v0r 174 3 stabilization stabilization NN cord-262511-96xp1v0r 174 4 and and CC cord-262511-96xp1v0r 174 5 translation translation NN cord-262511-96xp1v0r 174 6 in in IN cord-262511-96xp1v0r 174 7 T T NNP cord-262511-96xp1v0r 174 8 cell cell NN cord-262511-96xp1v0r 174 9 activation activation NN cord-262511-96xp1v0r 174 10 . . . cord-262511-96xp1v0r 175 1 APCs apc NNS cord-262511-96xp1v0r 175 2 , , , cord-262511-96xp1v0r 175 3 like like IN cord-262511-96xp1v0r 175 4 DC DC NNP cord-262511-96xp1v0r 175 5 , , , cord-262511-96xp1v0r 175 6 present present JJ cord-262511-96xp1v0r 175 7 antigens antigen NNS cord-262511-96xp1v0r 175 8 efficiently efficiently RB cord-262511-96xp1v0r 175 9 within within IN cord-262511-96xp1v0r 175 10 MHC MHC NNP cord-262511-96xp1v0r 175 11 to to IN cord-262511-96xp1v0r 175 12 T t NN cord-262511-96xp1v0r 175 13 cells cell NNS cord-262511-96xp1v0r 175 14 through through IN cord-262511-96xp1v0r 175 15 interaction interaction NN cord-262511-96xp1v0r 175 16 with with IN cord-262511-96xp1v0r 175 17 TcR. TcR. NNP cord-262511-96xp1v0r 176 1 Facilitated facilitate VBN cord-262511-96xp1v0r 176 2 by by IN cord-262511-96xp1v0r 176 3 other other JJ cord-262511-96xp1v0r 176 4 costimulatory costimulatory NN cord-262511-96xp1v0r 176 5 molecules molecule NNS cord-262511-96xp1v0r 176 6 , , , cord-262511-96xp1v0r 176 7 T T NNP cord-262511-96xp1v0r 176 8 cell cell NN cord-262511-96xp1v0r 176 9 activation activation NN cord-262511-96xp1v0r 176 10 occurs occur VBZ cord-262511-96xp1v0r 176 11 , , , cord-262511-96xp1v0r 176 12 resulting result VBG cord-262511-96xp1v0r 176 13 in in IN cord-262511-96xp1v0r 176 14 induction induction NN cord-262511-96xp1v0r 176 15 of of IN cord-262511-96xp1v0r 176 16 immediate immediate JJ cord-262511-96xp1v0r 176 17 early early JJ cord-262511-96xp1v0r 176 18 response response NN cord-262511-96xp1v0r 176 19 gene gene NN cord-262511-96xp1v0r 176 20 products product NNS cord-262511-96xp1v0r 176 21 such such JJ cord-262511-96xp1v0r 176 22 as as IN cord-262511-96xp1v0r 176 23 c c NNP cord-262511-96xp1v0r 176 24 - - HYPH cord-262511-96xp1v0r 176 25 fos fos NNP cord-262511-96xp1v0r 176 26 and and CC cord-262511-96xp1v0r 176 27 c c NNP cord-262511-96xp1v0r 176 28 - - : cord-262511-96xp1v0r 176 29 jun jun NNP cord-262511-96xp1v0r 176 30 . . . cord-262511-96xp1v0r 177 1 These these DT cord-262511-96xp1v0r 177 2 , , , cord-262511-96xp1v0r 177 3 as as IN cord-262511-96xp1v0r 177 4 AP-1 AP-1 NNP cord-262511-96xp1v0r 177 5 complex complex JJ cord-262511-96xp1v0r 177 6 , , , cord-262511-96xp1v0r 177 7 with with IN cord-262511-96xp1v0r 177 8 NFAT NFAT NNP cord-262511-96xp1v0r 177 9 activate activate VB cord-262511-96xp1v0r 177 10 the the DT cord-262511-96xp1v0r 177 11 IL-2 IL-2 NNP cord-262511-96xp1v0r 177 12 promoter promoter NN cord-262511-96xp1v0r 177 13 . . . cord-262511-96xp1v0r 178 1 Costimulatory costimulatory NN cord-262511-96xp1v0r 178 2 molecules molecule NNS cord-262511-96xp1v0r 178 3 , , , cord-262511-96xp1v0r 178 4 such such JJ cord-262511-96xp1v0r 178 5 as as IN cord-262511-96xp1v0r 178 6 CD28 CD28 NNP cord-262511-96xp1v0r 178 7 and and CC cord-262511-96xp1v0r 178 8 LFA-1 LFA-1 NNP cord-262511-96xp1v0r 178 9 on on IN cord-262511-96xp1v0r 178 10 T T NNP cord-262511-96xp1v0r 178 11 cells cell NNS cord-262511-96xp1v0r 178 12 , , , cord-262511-96xp1v0r 178 13 transduce transduce VBP cord-262511-96xp1v0r 178 14 signals signal NNS cord-262511-96xp1v0r 178 15 , , , cord-262511-96xp1v0r 178 16 which which WDT cord-262511-96xp1v0r 178 17 also also RB cord-262511-96xp1v0r 178 18 trigger trigger VBP cord-262511-96xp1v0r 178 19 mRNA mrna NN cord-262511-96xp1v0r 178 20 stabilization stabilization NN cord-262511-96xp1v0r 178 21 and and CC cord-262511-96xp1v0r 178 22 other other JJ cord-262511-96xp1v0r 178 23 post post JJ cord-262511-96xp1v0r 178 24 - - JJ cord-262511-96xp1v0r 178 25 transcriptional transcriptional JJ cord-262511-96xp1v0r 178 26 effects effect NNS cord-262511-96xp1v0r 178 27 . . . cord-262511-96xp1v0r 179 1 For for IN cord-262511-96xp1v0r 179 2 example example NN cord-262511-96xp1v0r 179 3 , , , cord-262511-96xp1v0r 179 4 HuR HuR NNP cord-262511-96xp1v0r 179 5 translocates translocates NNP cord-262511-96xp1v0r 179 6 from from IN cord-262511-96xp1v0r 179 7 the the DT cord-262511-96xp1v0r 179 8 nucleus nucleus NN cord-262511-96xp1v0r 179 9 to to IN cord-262511-96xp1v0r 179 10 the the DT cord-262511-96xp1v0r 179 11 cytoplasm cytoplasm NN cord-262511-96xp1v0r 179 12 and and CC cord-262511-96xp1v0r 179 13 stabilizes stabilize VBZ cord-262511-96xp1v0r 179 14 ARE are VBP cord-262511-96xp1v0r 179 15 - - HYPH cord-262511-96xp1v0r 179 16 mRNAs mRNAs NNPS cord-262511-96xp1v0r 179 17 , , , cord-262511-96xp1v0r 179 18 and and CC cord-262511-96xp1v0r 179 19 pin1 pin1 NNP cord-262511-96xp1v0r 179 20 isomerizes isomerize VBZ cord-262511-96xp1v0r 179 21 another another DT cord-262511-96xp1v0r 179 22 RNA RNA NNP cord-262511-96xp1v0r 179 23 - - HYPH cord-262511-96xp1v0r 179 24 binding bind VBG cord-262511-96xp1v0r 179 25 protein protein NN cord-262511-96xp1v0r 179 26 , , , cord-262511-96xp1v0r 179 27 AUF1 AUF1 NNP cord-262511-96xp1v0r 179 28 , , , cord-262511-96xp1v0r 179 29 leading lead VBG cord-262511-96xp1v0r 179 30 to to IN cord-262511-96xp1v0r 179 31 loss loss NN cord-262511-96xp1v0r 179 32 of of IN cord-262511-96xp1v0r 179 33 its -PRON- PRP$ cord-262511-96xp1v0r 179 34 mRNA mrna NN cord-262511-96xp1v0r 179 35 decay decay NN cord-262511-96xp1v0r 179 36 - - HYPH cord-262511-96xp1v0r 179 37 promoting promote VBG cord-262511-96xp1v0r 179 38 function function NN cord-262511-96xp1v0r 179 39 . . . cord-262511-96xp1v0r 180 1 These these DT cord-262511-96xp1v0r 180 2 events event NNS cord-262511-96xp1v0r 180 3 contribute contribute VBP cord-262511-96xp1v0r 180 4 to to IN cord-262511-96xp1v0r 180 5 early early JJ cord-262511-96xp1v0r 180 6 and and CC cord-262511-96xp1v0r 180 7 rapid rapid JJ cord-262511-96xp1v0r 180 8 response response NN cord-262511-96xp1v0r 180 9 of of IN cord-262511-96xp1v0r 180 10 T T NNP cord-262511-96xp1v0r 180 11 cell cell NN cord-262511-96xp1v0r 180 12 activation activation NN cord-262511-96xp1v0r 180 13 and and CC cord-262511-96xp1v0r 180 14 cytokine cytokine NN cord-262511-96xp1v0r 180 15 production production NN cord-262511-96xp1v0r 180 16 . . . cord-262511-96xp1v0r 181 1 In in IN cord-262511-96xp1v0r 181 2 later later JJ cord-262511-96xp1v0r 181 3 phase phase NN cord-262511-96xp1v0r 181 4 , , , cord-262511-96xp1v0r 181 5 shut shut VBN cord-262511-96xp1v0r 181 6 - - HYPH cord-262511-96xp1v0r 181 7 off off NN cord-262511-96xp1v0r 181 8 also also RB cord-262511-96xp1v0r 181 9 can can MD cord-262511-96xp1v0r 181 10 be be VB cord-262511-96xp1v0r 181 11 facilitated facilitate VBN cord-262511-96xp1v0r 181 12 by by IN cord-262511-96xp1v0r 181 13 post post JJ cord-262511-96xp1v0r 181 14 - - JJ cord-262511-96xp1v0r 181 15 transcriptional transcriptional JJ cord-262511-96xp1v0r 181 16 mechanisms mechanism NNS cord-262511-96xp1v0r 181 17 including include VBG cord-262511-96xp1v0r 181 18 mRNA mRNA NNP cord-262511-96xp1v0r 181 19 destabilization destabilization NN cord-262511-96xp1v0r 181 20 and and CC cord-262511-96xp1v0r 181 21 translational translational JJ cord-262511-96xp1v0r 181 22 arrest arrest NN cord-262511-96xp1v0r 181 23 . . . cord-262511-96xp1v0r 182 1 Details detail NNS cord-262511-96xp1v0r 182 2 are be VBP cord-262511-96xp1v0r 182 3 given give VBN cord-262511-96xp1v0r 182 4 in in IN cord-262511-96xp1v0r 182 5 the the DT cord-262511-96xp1v0r 182 6 text text NN cord-262511-96xp1v0r 182 7 . . . cord-262511-96xp1v0r 183 1 pin1 pin1 NNP cord-262511-96xp1v0r 183 2 , , , cord-262511-96xp1v0r 183 3 Peptidyl Peptidyl NNP cord-262511-96xp1v0r 183 4 - - HYPH cord-262511-96xp1v0r 183 5 prolyl prolyl JJ cord-262511-96xp1v0r 183 6 isomerase isomerase NN cord-262511-96xp1v0r 183 7 ; ; : cord-262511-96xp1v0r 183 8 TIA TIA NNP cord-262511-96xp1v0r 183 9 , , , cord-262511-96xp1v0r 183 10 T T NNP cord-262511-96xp1v0r 183 11 cell cell NN cord-262511-96xp1v0r 183 12 intracellular intracellular JJ cord-262511-96xp1v0r 183 13 antigen antigen NN cord-262511-96xp1v0r 183 14 . . . cord-262511-96xp1v0r 184 1 volves volves NNP cord-262511-96xp1v0r 184 2 translation translation NN cord-262511-96xp1v0r 184 3 repressor repressor NN cord-262511-96xp1v0r 184 4 proteins protein NNS cord-262511-96xp1v0r 184 5 , , , cord-262511-96xp1v0r 184 6 TIA-1 TIA-1 NNP cord-262511-96xp1v0r 184 7 , , , cord-262511-96xp1v0r 184 8 and and CC cord-262511-96xp1v0r 184 9 TIA-1-related tia-1-related JJ cord-262511-96xp1v0r 184 10 protein protein NN cord-262511-96xp1v0r 184 11 , , , cord-262511-96xp1v0r 184 12 which which WDT cord-262511-96xp1v0r 184 13 operate operate VBP cord-262511-96xp1v0r 184 14 during during IN cord-262511-96xp1v0r 184 15 priming prime VBG cord-262511-96xp1v0r 184 16 and and CC cord-262511-96xp1v0r 184 17 restrict restrict VB cord-262511-96xp1v0r 184 18 T T NNP cord-262511-96xp1v0r 184 19 cell cell NN cord-262511-96xp1v0r 184 20 function function NN cord-262511-96xp1v0r 184 21 by by IN cord-262511-96xp1v0r 184 22 recruiting recruit VBG cord-262511-96xp1v0r 184 23 untranslated untranslated JJ cord-262511-96xp1v0r 184 24 mRNAs mrnas IN cord-262511-96xp1v0r 184 25 into into IN cord-262511-96xp1v0r 184 26 stress stress NN cord-262511-96xp1v0r 184 27 granules granule NNS cord-262511-96xp1v0r 184 28 , , , cord-262511-96xp1v0r 184 29 discrete discrete JJ cord-262511-96xp1v0r 184 30 cytoplasmic cytoplasmic JJ cord-262511-96xp1v0r 184 31 foci focus NNS cord-262511-96xp1v0r 184 32 triggered trigger VBN cord-262511-96xp1v0r 184 33 by by IN cord-262511-96xp1v0r 185 1 eIF2 eif2 IN cord-262511-96xp1v0r 185 2 ␣ ␣ NN cord-262511-96xp1v0r 185 3 phosphorylation phosphorylation NN cord-262511-96xp1v0r 185 4 [ [ -LRB- cord-262511-96xp1v0r 185 5 88 88 CD cord-262511-96xp1v0r 185 6 ] ] -RRB- cord-262511-96xp1v0r 185 7 . . . cord-262511-96xp1v0r 186 1 Also also RB cord-262511-96xp1v0r 186 2 , , , cord-262511-96xp1v0r 186 3 the the DT cord-262511-96xp1v0r 186 4 p38 p38 CD cord-262511-96xp1v0r 186 5 activity activity NN cord-262511-96xp1v0r 186 6 , , , cord-262511-96xp1v0r 186 7 which which WDT cord-262511-96xp1v0r 186 8 leads lead VBZ cord-262511-96xp1v0r 186 9 to to IN cord-262511-96xp1v0r 186 10 IL-4 IL-4 NNP cord-262511-96xp1v0r 186 11 mRNA mRNA NNP cord-262511-96xp1v0r 186 12 stabilization stabilization NN cord-262511-96xp1v0r 186 13 , , , cord-262511-96xp1v0r 186 14 modulates modulate VBZ cord-262511-96xp1v0r 186 15 differentiation differentiation NN cord-262511-96xp1v0r 186 16 of of IN cord-262511-96xp1v0r 186 17 naive naive JJ cord-262511-96xp1v0r 186 18 precursor precursor NN cord-262511-96xp1v0r 186 19 T t NN cord-262511-96xp1v0r 186 20 cells cell NNS cord-262511-96xp1v0r 186 21 to to IN cord-262511-96xp1v0r 186 22 Th2 Th2 NNP cord-262511-96xp1v0r 186 23 direction direction NN cord-262511-96xp1v0r 186 24 [ [ -LRB- cord-262511-96xp1v0r 186 25 89 89 CD cord-262511-96xp1v0r 186 26 ] ] -RRB- cord-262511-96xp1v0r 186 27 . . . cord-262511-96xp1v0r 187 1 Post post JJ cord-262511-96xp1v0r 187 2 - - JJ cord-262511-96xp1v0r 187 3 transcriptional transcriptional JJ cord-262511-96xp1v0r 187 4 control control NN cord-262511-96xp1v0r 187 5 plays play VBZ cord-262511-96xp1v0r 187 6 a a DT cord-262511-96xp1v0r 187 7 significant significant JJ cord-262511-96xp1v0r 187 8 part part NN cord-262511-96xp1v0r 187 9 in in IN cord-262511-96xp1v0r 187 10 specific specific JJ cord-262511-96xp1v0r 187 11 pathways pathway NNS cord-262511-96xp1v0r 187 12 that that WDT cord-262511-96xp1v0r 187 13 regulate regulate VBP cord-262511-96xp1v0r 187 14 T T NNP cord-262511-96xp1v0r 187 15 cell cell NN cord-262511-96xp1v0r 187 16 activation activation NN cord-262511-96xp1v0r 187 17 and and CC cord-262511-96xp1v0r 187 18 involves involve VBZ cord-262511-96xp1v0r 187 19 several several JJ cord-262511-96xp1v0r 187 20 types type NNS cord-262511-96xp1v0r 187 21 of of IN cord-262511-96xp1v0r 187 22 modulators modulator NNS cord-262511-96xp1v0r 187 23 , , , cord-262511-96xp1v0r 187 24 including include VBG cord-262511-96xp1v0r 187 25 suppressive suppressive JJ cord-262511-96xp1v0r 187 26 cytokines cytokine NNS cord-262511-96xp1v0r 187 27 , , , cord-262511-96xp1v0r 187 28 miRNA miRNA NNP cord-262511-96xp1v0r 187 29 , , , cord-262511-96xp1v0r 187 30 and and CC cord-262511-96xp1v0r 187 31 adaptors adaptor NNS cord-262511-96xp1v0r 187 32 . . . cord-262511-96xp1v0r 188 1 When when WRB cord-262511-96xp1v0r 188 2 cytokines cytokine NNS cord-262511-96xp1v0r 188 3 such such JJ cord-262511-96xp1v0r 188 4 as as IN cord-262511-96xp1v0r 188 5 IFN- IFN- NNP cord-262511-96xp1v0r 188 6 ␣ ␣ NNP cord-262511-96xp1v0r 188 7 / / SYM cord-262511-96xp1v0r 188 8 ␤ ␤ XX cord-262511-96xp1v0r 188 9 , , , cord-262511-96xp1v0r 188 10 IL-4 IL-4 NNP cord-262511-96xp1v0r 188 11 , , , cord-262511-96xp1v0r 188 12 and and CC cord-262511-96xp1v0r 188 13 IL-10 IL-10 NNP cord-262511-96xp1v0r 188 14 dampen dampen VBP cord-262511-96xp1v0r 188 15 the the DT cord-262511-96xp1v0r 188 16 immune immune JJ cord-262511-96xp1v0r 188 17 response response NN cord-262511-96xp1v0r 188 18 , , , cord-262511-96xp1v0r 188 19 they -PRON- PRP cord-262511-96xp1v0r 188 20 tend tend VBP cord-262511-96xp1v0r 188 21 to to TO cord-262511-96xp1v0r 188 22 destabilize destabilize VB cord-262511-96xp1v0r 188 23 mRNAs mRNAs NNPS cord-262511-96xp1v0r 188 24 involved involve VBN cord-262511-96xp1v0r 188 25 . . . cord-262511-96xp1v0r 189 1 IFN IFN NNP cord-262511-96xp1v0r 189 2 such such JJ cord-262511-96xp1v0r 189 3 as as IN cord-262511-96xp1v0r 189 4 IFN- IFN- NNP cord-262511-96xp1v0r 189 5 ␤ ␤ NNP cord-262511-96xp1v0r 189 6 or or CC cord-262511-96xp1v0r 189 7 - - HYPH cord-262511-96xp1v0r 189 8 ␥ ␥ XX cord-262511-96xp1v0r 189 9 , , , cord-262511-96xp1v0r 189 10 when when WRB cord-262511-96xp1v0r 189 11 in in IN cord-262511-96xp1v0r 189 12 combination combination NN cord-262511-96xp1v0r 189 13 with with IN cord-262511-96xp1v0r 189 14 LPS LPS NNP cord-262511-96xp1v0r 189 15 , , , cord-262511-96xp1v0r 189 16 induces induce VBZ cord-262511-96xp1v0r 189 17 TTP TTP NNP cord-262511-96xp1v0r 189 18 transcription transcription NN cord-262511-96xp1v0r 189 19 and and CC cord-262511-96xp1v0r 189 20 thereby thereby RB cord-262511-96xp1v0r 189 21 reduces reduce VBZ cord-262511-96xp1v0r 189 22 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 189 23 cytokines cytokine NNS cord-262511-96xp1v0r 189 24 , , , cord-262511-96xp1v0r 189 25 namely namely RB cord-262511-96xp1v0r 189 26 , , , cord-262511-96xp1v0r 189 27 TNF- TNF- NNP cord-262511-96xp1v0r 189 28 ␣ ␣ NN cord-262511-96xp1v0r 189 29 and and CC cord-262511-96xp1v0r 189 30 IL-6 IL-6 NNP cord-262511-96xp1v0r 189 31 and and CC cord-262511-96xp1v0r 189 32 the the DT cord-262511-96xp1v0r 189 33 chemokines chemokine NNS cord-262511-96xp1v0r 189 34 CCL2 CCL2 NNP cord-262511-96xp1v0r 189 35 ( ( -LRB- cord-262511-96xp1v0r 189 36 MCP-1 MCP-1 NNP cord-262511-96xp1v0r 189 37 ) ) -RRB- cord-262511-96xp1v0r 189 38 and and CC cord-262511-96xp1v0r 189 39 CCL3 CCL3 NNP cord-262511-96xp1v0r 189 40 ( ( -LRB- cord-262511-96xp1v0r 190 1 MIP-1 mip-1 NN cord-262511-96xp1v0r 190 2 ␣ ␣ NFP cord-262511-96xp1v0r 190 3 ) ) -RRB- cord-262511-96xp1v0r 190 4 [ [ -LRB- cord-262511-96xp1v0r 190 5 90 90 CD cord-262511-96xp1v0r 190 6 ] ] -RRB- cord-262511-96xp1v0r 190 7 . . . cord-262511-96xp1v0r 191 1 This this DT cord-262511-96xp1v0r 191 2 happens happen VBZ cord-262511-96xp1v0r 191 3 in in IN cord-262511-96xp1v0r 191 4 a a DT cord-262511-96xp1v0r 191 5 p38 p38 CD cord-262511-96xp1v0r 191 6 MAPK MAPK NNP cord-262511-96xp1v0r 191 7 - - HYPH cord-262511-96xp1v0r 191 8 dependent dependent JJ cord-262511-96xp1v0r 191 9 manner manner NN cord-262511-96xp1v0r 191 10 , , , cord-262511-96xp1v0r 191 11 as as IN cord-262511-96xp1v0r 191 12 revealed reveal VBN cord-262511-96xp1v0r 191 13 with with IN cord-262511-96xp1v0r 191 14 TTP ttp NN cord-262511-96xp1v0r 191 15 - - HYPH cord-262511-96xp1v0r 191 16 knockout knockout NN cord-262511-96xp1v0r 191 17 mouse mouse NN cord-262511-96xp1v0r 191 18 embryo embryo NN cord-262511-96xp1v0r 191 19 fibroblasts fibroblast NNS cord-262511-96xp1v0r 191 20 [ [ -LRB- cord-262511-96xp1v0r 191 21 90 90 CD cord-262511-96xp1v0r 191 22 ] ] -RRB- cord-262511-96xp1v0r 191 23 . . . cord-262511-96xp1v0r 192 1 The the DT cord-262511-96xp1v0r 192 2 TTP TTP NNP cord-262511-96xp1v0r 192 3 transcription transcription NN cord-262511-96xp1v0r 192 4 appears appear VBZ cord-262511-96xp1v0r 192 5 to to TO cord-262511-96xp1v0r 192 6 require require VB cord-262511-96xp1v0r 192 7 a a DT cord-262511-96xp1v0r 192 8 functional functional JJ cord-262511-96xp1v0r 192 9 , , , cord-262511-96xp1v0r 192 10 IFN- IFN- NNP cord-262511-96xp1v0r 192 11 ␥ ␥ CD cord-262511-96xp1v0r 192 12 -activated -activated JJ cord-262511-96xp1v0r 192 13 sequence sequence NN cord-262511-96xp1v0r 192 14 , , , cord-262511-96xp1v0r 192 15 which which WDT cord-262511-96xp1v0r 192 16 recruits recruit VBZ cord-262511-96xp1v0r 192 17 STAT1 stat1 XX cord-262511-96xp1v0r 192 18 onto onto IN cord-262511-96xp1v0r 192 19 the the DT cord-262511-96xp1v0r 192 20 TTP TTP NNP cord-262511-96xp1v0r 192 21 promoter promoter NN cord-262511-96xp1v0r 192 22 . . . cord-262511-96xp1v0r 193 1 As as IN cord-262511-96xp1v0r 193 2 TTP TTP NNP cord-262511-96xp1v0r 193 3 is be VBZ cord-262511-96xp1v0r 193 4 considered consider VBN cord-262511-96xp1v0r 193 5 an an DT cord-262511-96xp1v0r 193 6 anti anti JJ cord-262511-96xp1v0r 193 7 - - JJ cord-262511-96xp1v0r 193 8 inflammatory inflammatory JJ cord-262511-96xp1v0r 193 9 mediator mediator NN cord-262511-96xp1v0r 193 10 and and CC cord-262511-96xp1v0r 193 11 suppresses suppress VBZ cord-262511-96xp1v0r 193 12 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 193 13 cytokines cytokine NNS cord-262511-96xp1v0r 193 14 , , , cord-262511-96xp1v0r 193 15 it -PRON- PRP cord-262511-96xp1v0r 193 16 is be VBZ cord-262511-96xp1v0r 193 17 possible possible JJ cord-262511-96xp1v0r 193 18 that that IN cord-262511-96xp1v0r 193 19 at at IN cord-262511-96xp1v0r 193 20 least least JJS cord-262511-96xp1v0r 193 21 some some DT cord-262511-96xp1v0r 193 22 of of IN cord-262511-96xp1v0r 193 23 the the DT cord-262511-96xp1v0r 193 24 molecules molecule NNS cord-262511-96xp1v0r 193 25 with with IN cord-262511-96xp1v0r 193 26 anti anti JJ cord-262511-96xp1v0r 193 27 - - JJ cord-262511-96xp1v0r 193 28 inflammatory inflammatory JJ cord-262511-96xp1v0r 193 29 action action NN cord-262511-96xp1v0r 193 30 induce induce VB cord-262511-96xp1v0r 193 31 TTP TTP NNP cord-262511-96xp1v0r 193 32 or or CC cord-262511-96xp1v0r 193 33 its -PRON- PRP$ cord-262511-96xp1v0r 193 34 activity activity NN cord-262511-96xp1v0r 193 35 . . . cord-262511-96xp1v0r 194 1 Indeed indeed RB cord-262511-96xp1v0r 194 2 , , , cord-262511-96xp1v0r 194 3 glucocorticoids glucocorticoid NNS cord-262511-96xp1v0r 194 4 can can MD cord-262511-96xp1v0r 194 5 induce induce VB cord-262511-96xp1v0r 194 6 the the DT cord-262511-96xp1v0r 194 7 transcription transcription NN cord-262511-96xp1v0r 194 8 of of IN cord-262511-96xp1v0r 194 9 TTP TTP NNP cord-262511-96xp1v0r 194 10 in in IN cord-262511-96xp1v0r 194 11 the the DT cord-262511-96xp1v0r 194 12 A549 a549 JJ cord-262511-96xp1v0r 194 13 lung lung NN cord-262511-96xp1v0r 194 14 epithelial epithelial JJ cord-262511-96xp1v0r 194 15 cell cell NN cord-262511-96xp1v0r 194 16 line line NN cord-262511-96xp1v0r 194 17 ; ; : cord-262511-96xp1v0r 194 18 small small JJ cord-262511-96xp1v0r 194 19 interfering interfere VBG cord-262511-96xp1v0r 194 20 RNA RNA NNP cord-262511-96xp1v0r 194 21 to to IN cord-262511-96xp1v0r 194 22 TTP TTP NNP cord-262511-96xp1v0r 194 23 prevented prevent VBD cord-262511-96xp1v0r 194 24 dexamethasone dexamethasone NN cord-262511-96xp1v0r 194 25 - - HYPH cord-262511-96xp1v0r 194 26 induced induce VBN cord-262511-96xp1v0r 194 27 reduction reduction NN cord-262511-96xp1v0r 194 28 of of IN cord-262511-96xp1v0r 194 29 TNF- TNF- NNP cord-262511-96xp1v0r 194 30 ␣ ␣ NNP cord-262511-96xp1v0r 194 31 mRNA mrna NN cord-262511-96xp1v0r 194 32 stability stability NN cord-262511-96xp1v0r 194 33 and and CC cord-262511-96xp1v0r 194 34 activity activity NN cord-262511-96xp1v0r 194 35 of of IN cord-262511-96xp1v0r 194 36 reporter reporter NN cord-262511-96xp1v0r 194 37 fused fuse VBN cord-262511-96xp1v0r 194 38 with with IN cord-262511-96xp1v0r 194 39 TNF- TNF- NNP cord-262511-96xp1v0r 194 40 ␣ ␣ NNP cord-262511-96xp1v0r 194 41 3ЈUTR 3јutr CD cord-262511-96xp1v0r 194 42 [ [ -LRB- cord-262511-96xp1v0r 194 43 91 91 CD cord-262511-96xp1v0r 194 44 ] ] -RRB- cord-262511-96xp1v0r 194 45 . . . cord-262511-96xp1v0r 195 1 On on IN cord-262511-96xp1v0r 195 2 the the DT cord-262511-96xp1v0r 195 3 contrary contrary NN cord-262511-96xp1v0r 195 4 , , , cord-262511-96xp1v0r 195 5 this this DT cord-262511-96xp1v0r 195 6 action action NN cord-262511-96xp1v0r 195 7 may may MD cord-262511-96xp1v0r 195 8 be be VB cord-262511-96xp1v0r 195 9 tissuetype tissuetype NN cord-262511-96xp1v0r 195 10 - - HYPH cord-262511-96xp1v0r 195 11 specific specific JJ cord-262511-96xp1v0r 195 12 , , , cord-262511-96xp1v0r 195 13 as as IN cord-262511-96xp1v0r 195 14 dexamethasone dexamethasone NN cord-262511-96xp1v0r 195 15 may may MD cord-262511-96xp1v0r 195 16 inhibit inhibit VB cord-262511-96xp1v0r 195 17 rather rather RB cord-262511-96xp1v0r 195 18 than than IN cord-262511-96xp1v0r 195 19 induce induce VB cord-262511-96xp1v0r 195 20 TTP TTP NNP cord-262511-96xp1v0r 195 21 in in IN cord-262511-96xp1v0r 195 22 activated activate VBN cord-262511-96xp1v0r 195 23 macrophages macrophage NNS cord-262511-96xp1v0r 195 24 [ [ -LRB- cord-262511-96xp1v0r 195 25 92 92 CD cord-262511-96xp1v0r 195 26 ] ] -RRB- cord-262511-96xp1v0r 195 27 . . . cord-262511-96xp1v0r 196 1 IL-10 IL-10 NNP cord-262511-96xp1v0r 196 2 is be VBZ cord-262511-96xp1v0r 196 3 a a DT cord-262511-96xp1v0r 196 4 potent potent JJ cord-262511-96xp1v0r 196 5 , , , cord-262511-96xp1v0r 196 6 suppressive suppressive JJ cord-262511-96xp1v0r 196 7 cytokine cytokine NN cord-262511-96xp1v0r 196 8 , , , cord-262511-96xp1v0r 196 9 which which WDT cord-262511-96xp1v0r 196 10 can can MD cord-262511-96xp1v0r 196 11 inhibit inhibit VB cord-262511-96xp1v0r 196 12 macrophage macrophage NN cord-262511-96xp1v0r 196 13 action action NN cord-262511-96xp1v0r 196 14 and and CC cord-262511-96xp1v0r 196 15 generation generation NN cord-262511-96xp1v0r 196 16 of of IN cord-262511-96xp1v0r 196 17 Th2 th2 CD cord-262511-96xp1v0r 196 18 lymphocytes lymphocyte NNS cord-262511-96xp1v0r 196 19 . . . cord-262511-96xp1v0r 197 1 It -PRON- PRP cord-262511-96xp1v0r 197 2 is be VBZ cord-262511-96xp1v0r 197 3 capable capable JJ cord-262511-96xp1v0r 197 4 of of IN cord-262511-96xp1v0r 197 5 inhibiting inhibit VBG cord-262511-96xp1v0r 197 6 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 197 7 cytokines cytokine NNS cord-262511-96xp1v0r 197 8 and and CC cord-262511-96xp1v0r 197 9 Th1 th1 NN cord-262511-96xp1v0r 197 10 cytokines cytokine NNS cord-262511-96xp1v0r 197 11 , , , cord-262511-96xp1v0r 197 12 such such JJ cord-262511-96xp1v0r 197 13 as as IN cord-262511-96xp1v0r 197 14 TNF- TNF- NNP cord-262511-96xp1v0r 197 15 ␣ ␣ NNP cord-262511-96xp1v0r 197 16 , , , cord-262511-96xp1v0r 197 17 IFN- IFN- NNP cord-262511-96xp1v0r 197 18 ␥ ␥ NNP cord-262511-96xp1v0r 197 19 , , , cord-262511-96xp1v0r 198 1 IL-2 IL-2 NNP cord-262511-96xp1v0r 198 2 , , , cord-262511-96xp1v0r 198 3 IL-3 IL-3 NNP cord-262511-96xp1v0r 198 4 , , , cord-262511-96xp1v0r 198 5 and and CC cord-262511-96xp1v0r 198 6 GM GM NNP cord-262511-96xp1v0r 198 7 - - HYPH cord-262511-96xp1v0r 198 8 CSF CSF NNP cord-262511-96xp1v0r 198 9 . . . cord-262511-96xp1v0r 199 1 IL-10 IL-10 NNP cord-262511-96xp1v0r 199 2 destabilizes destabilize VBZ cord-262511-96xp1v0r 200 1 TNF- TNF- NNP cord-262511-96xp1v0r 200 2 ␣ ␣ NNP cord-262511-96xp1v0r 200 3 mRNA mrna NN cord-262511-96xp1v0r 201 1 and and CC cord-262511-96xp1v0r 201 2 probably probably RB cord-262511-96xp1v0r 201 3 others other NNS cord-262511-96xp1v0r 201 4 by by IN cord-262511-96xp1v0r 201 5 inhibiting inhibit VBG cord-262511-96xp1v0r 201 6 the the DT cord-262511-96xp1v0r 201 7 binding binding NN cord-262511-96xp1v0r 201 8 of of IN cord-262511-96xp1v0r 201 9 HuR hur NN cord-262511-96xp1v0r 201 10 to to IN cord-262511-96xp1v0r 201 11 the the DT cord-262511-96xp1v0r 201 12 AREs are NNS cord-262511-96xp1v0r 201 13 in in IN cord-262511-96xp1v0r 201 14 the the DT cord-262511-96xp1v0r 201 15 3ЈUTR 3јutr CD cord-262511-96xp1v0r 202 1 ; ; : cord-262511-96xp1v0r 202 2 this this DT cord-262511-96xp1v0r 202 3 effect effect NN cord-262511-96xp1v0r 202 4 appears appear VBZ cord-262511-96xp1v0r 202 5 also also RB cord-262511-96xp1v0r 202 6 to to TO cord-262511-96xp1v0r 202 7 be be VB cord-262511-96xp1v0r 202 8 dependent dependent JJ cord-262511-96xp1v0r 202 9 on on IN cord-262511-96xp1v0r 202 10 the the DT cord-262511-96xp1v0r 202 11 p38 p38 JJ cord-262511-96xp1v0r 202 12 MAPK MAPK NNP cord-262511-96xp1v0r 202 13 pathway pathway NN cord-262511-96xp1v0r 202 14 [ [ -LRB- cord-262511-96xp1v0r 202 15 93 93 CD cord-262511-96xp1v0r 202 16 ] ] -RRB- cord-262511-96xp1v0r 202 17 . . . cord-262511-96xp1v0r 203 1 Another another DT cord-262511-96xp1v0r 203 2 anti anti JJ cord-262511-96xp1v0r 203 3 - - JJ cord-262511-96xp1v0r 203 4 inflammatory inflammatory JJ cord-262511-96xp1v0r 203 5 cytokine cytokine NN cord-262511-96xp1v0r 203 6 , , , cord-262511-96xp1v0r 203 7 IL-4 IL-4 NNP cord-262511-96xp1v0r 203 8 , , , cord-262511-96xp1v0r 203 9 can can MD cord-262511-96xp1v0r 203 10 suppress suppress VB cord-262511-96xp1v0r 203 11 FPR1 FPR1 NNP cord-262511-96xp1v0r 203 12 mRNA mrna NN cord-262511-96xp1v0r 203 13 expression expression NN cord-262511-96xp1v0r 203 14 via via IN cord-262511-96xp1v0r 203 15 a a DT cord-262511-96xp1v0r 203 16 mechanism mechanism NN cord-262511-96xp1v0r 203 17 , , , cord-262511-96xp1v0r 203 18 which which WDT cord-262511-96xp1v0r 203 19 acts act VBZ cord-262511-96xp1v0r 203 20 on on IN cord-262511-96xp1v0r 203 21 primary primary JJ cord-262511-96xp1v0r 203 22 transcripts transcript NNS cord-262511-96xp1v0r 203 23 prior prior RB cord-262511-96xp1v0r 203 24 to to IN cord-262511-96xp1v0r 203 25 maturation maturation NN cord-262511-96xp1v0r 203 26 and and CC cord-262511-96xp1v0r 203 27 depends depend VBZ cord-262511-96xp1v0r 203 28 on on IN cord-262511-96xp1v0r 203 29 the the DT cord-262511-96xp1v0r 203 30 constitutive constitutive JJ cord-262511-96xp1v0r 203 31 instability instability NN cord-262511-96xp1v0r 203 32 of of IN cord-262511-96xp1v0r 203 33 pre pre JJ cord-262511-96xp1v0r 203 34 - - JJ cord-262511-96xp1v0r 203 35 existing existing JJ cord-262511-96xp1v0r 203 36 mRNA mrna NN cord-262511-96xp1v0r 203 37 [ [ -LRB- cord-262511-96xp1v0r 203 38 94 94 CD cord-262511-96xp1v0r 203 39 ] ] -RRB- cord-262511-96xp1v0r 203 40 . . . cord-262511-96xp1v0r 204 1 A a DT cord-262511-96xp1v0r 204 2 possible possible JJ cord-262511-96xp1v0r 204 3 pathway pathway NN cord-262511-96xp1v0r 204 4 , , , cord-262511-96xp1v0r 204 5 which which WDT cord-262511-96xp1v0r 204 6 may may MD cord-262511-96xp1v0r 204 7 involve involve VB cord-262511-96xp1v0r 204 8 mRNA mrna NN cord-262511-96xp1v0r 204 9 stability stability NN cord-262511-96xp1v0r 204 10 changes change NNS cord-262511-96xp1v0r 204 11 as as IN cord-262511-96xp1v0r 204 12 a a DT cord-262511-96xp1v0r 204 13 result result NN cord-262511-96xp1v0r 204 14 of of IN cord-262511-96xp1v0r 204 15 negative negative JJ cord-262511-96xp1v0r 204 16 regulation regulation NN cord-262511-96xp1v0r 204 17 of of IN cord-262511-96xp1v0r 204 18 TcR TcR NNP cord-262511-96xp1v0r 204 19 / / , cord-262511-96xp1v0r 204 20 CD28-induced CD28-induced NNP cord-262511-96xp1v0r 204 21 T T NNP cord-262511-96xp1v0r 204 22 cell cell NN cord-262511-96xp1v0r 204 23 activation activation NN cord-262511-96xp1v0r 204 24 , , , cord-262511-96xp1v0r 204 25 is be VBZ cord-262511-96xp1v0r 204 26 the the DT cord-262511-96xp1v0r 204 27 association association NN cord-262511-96xp1v0r 204 28 between between IN cord-262511-96xp1v0r 204 29 adaptor adaptor NN cord-262511-96xp1v0r 204 30 in in IN cord-262511-96xp1v0r 204 31 lymphocytes lymphocyte NNS cord-262511-96xp1v0r 204 32 of of IN cord-262511-96xp1v0r 204 33 unknown unknown JJ cord-262511-96xp1v0r 204 34 function function NN cord-262511-96xp1v0r 204 35 ( ( -LRB- cord-262511-96xp1v0r 204 36 ALX ALX NNP cord-262511-96xp1v0r 204 37 ) ) -RRB- cord-262511-96xp1v0r 204 38 and and CC cord-262511-96xp1v0r 204 39 membrane membrane NN cord-262511-96xp1v0r 204 40 - - HYPH cord-262511-96xp1v0r 204 41 associated associate VBN cord-262511-96xp1v0r 204 42 adaptor adaptor NN cord-262511-96xp1v0r 204 43 protein protein NN cord-262511-96xp1v0r 204 44 ( ( -LRB- cord-262511-96xp1v0r 204 45 LAX LAX NNP cord-262511-96xp1v0r 204 46 ) ) -RRB- cord-262511-96xp1v0r 204 47 adaptors adaptor NNS cord-262511-96xp1v0r 204 48 . . . cord-262511-96xp1v0r 205 1 Work work VB cord-262511-96xp1v0r 205 2 with with IN cord-262511-96xp1v0r 205 3 ALX alx NN cord-262511-96xp1v0r 205 4 - - HYPH cord-262511-96xp1v0r 205 5 deficient deficient JJ cord-262511-96xp1v0r 205 6 knockout knockout NN cord-262511-96xp1v0r 205 7 mice mouse NNS cord-262511-96xp1v0r 205 8 suggested suggest VBD cord-262511-96xp1v0r 205 9 that that IN cord-262511-96xp1v0r 205 10 the the DT cord-262511-96xp1v0r 205 11 ALX ALX NNP cord-262511-96xp1v0r 205 12 / / SYM cord-262511-96xp1v0r 205 13 LAX LAX NNP cord-262511-96xp1v0r 205 14 association association NN cord-262511-96xp1v0r 205 15 may may MD cord-262511-96xp1v0r 205 16 inhibit inhibit VB cord-262511-96xp1v0r 205 17 the the DT cord-262511-96xp1v0r 205 18 p38 p38 CD cord-262511-96xp1v0r 205 19 MAPK MAPK NNP cord-262511-96xp1v0r 205 20 pathway pathway NN cord-262511-96xp1v0r 205 21 and and CC cord-262511-96xp1v0r 205 22 IL-2 il-2 NN cord-262511-96xp1v0r 205 23 production production NN cord-262511-96xp1v0r 205 24 [ [ -LRB- cord-262511-96xp1v0r 205 25 95 95 CD cord-262511-96xp1v0r 205 26 ] ] -RRB- cord-262511-96xp1v0r 205 27 . . . cord-262511-96xp1v0r 206 1 Specifically specifically RB cord-262511-96xp1v0r 206 2 , , , cord-262511-96xp1v0r 206 3 the the DT cord-262511-96xp1v0r 206 4 upstream upstream JJ cord-262511-96xp1v0r 206 5 , , , cord-262511-96xp1v0r 206 6 regulatory regulatory JJ cord-262511-96xp1v0r 206 7 MAPKs mapk NNS cord-262511-96xp1v0r 206 8 , , , cord-262511-96xp1v0r 206 9 MKK3/6 MKK3/6 NNP cord-262511-96xp1v0r 206 10 , , , cord-262511-96xp1v0r 206 11 have have VBP cord-262511-96xp1v0r 206 12 been be VBN cord-262511-96xp1v0r 206 13 found find VBN cord-262511-96xp1v0r 206 14 to to TO cord-262511-96xp1v0r 206 15 be be VB cord-262511-96xp1v0r 206 16 constitutively constitutively RB cord-262511-96xp1v0r 206 17 activated activate VBN cord-262511-96xp1v0r 206 18 in in IN cord-262511-96xp1v0r 206 19 ALX alx NN cord-262511-96xp1v0r 206 20 - - HYPH cord-262511-96xp1v0r 206 21 deficient deficient JJ cord-262511-96xp1v0r 206 22 mice mouse NNS cord-262511-96xp1v0r 206 23 [ [ -LRB- cord-262511-96xp1v0r 206 24 95 95 CD cord-262511-96xp1v0r 206 25 ] ] -RRB- cord-262511-96xp1v0r 206 26 . . . cord-262511-96xp1v0r 207 1 As as IN cord-262511-96xp1v0r 207 2 p38 p38 CD cord-262511-96xp1v0r 207 3 MAPK MAPK NNP cord-262511-96xp1v0r 207 4 is be VBZ cord-262511-96xp1v0r 207 5 involved involve VBN cord-262511-96xp1v0r 207 6 in in IN cord-262511-96xp1v0r 207 7 IL-2 IL-2 NNP cord-262511-96xp1v0r 207 8 mRNA mRNA NNP cord-262511-96xp1v0r 207 9 stabilization stabilization NN cord-262511-96xp1v0r 207 10 , , , cord-262511-96xp1v0r 207 11 it -PRON- PRP cord-262511-96xp1v0r 207 12 is be VBZ cord-262511-96xp1v0r 207 13 possible possible JJ cord-262511-96xp1v0r 207 14 that that IN cord-262511-96xp1v0r 207 15 negative negative JJ cord-262511-96xp1v0r 207 16 regulation regulation NN cord-262511-96xp1v0r 207 17 by by IN cord-262511-96xp1v0r 207 18 ALX ALX NNP cord-262511-96xp1v0r 207 19 occurs occur VBZ cord-262511-96xp1v0r 207 20 via via IN cord-262511-96xp1v0r 207 21 a a DT cord-262511-96xp1v0r 207 22 post post JJ cord-262511-96xp1v0r 207 23 - - JJ cord-262511-96xp1v0r 207 24 transcriptional transcriptional JJ cord-262511-96xp1v0r 207 25 mechanism mechanism NN cord-262511-96xp1v0r 207 26 as as RB cord-262511-96xp1v0r 207 27 well well RB cord-262511-96xp1v0r 207 28 . . . cord-262511-96xp1v0r 208 1 Negative negative JJ cord-262511-96xp1v0r 208 2 regulation regulation NN cord-262511-96xp1v0r 208 3 of of IN cord-262511-96xp1v0r 208 4 T T NNP cord-262511-96xp1v0r 208 5 cell cell NN cord-262511-96xp1v0r 208 6 activation activation NN cord-262511-96xp1v0r 208 7 and and CC cord-262511-96xp1v0r 208 8 cytokine cytokine NN cord-262511-96xp1v0r 208 9 production production NN cord-262511-96xp1v0r 208 10 can can MD cord-262511-96xp1v0r 208 11 also also RB cord-262511-96xp1v0r 208 12 occur occur VB cord-262511-96xp1v0r 208 13 by by IN cord-262511-96xp1v0r 208 14 a a DT cord-262511-96xp1v0r 208 15 miRNA miRNA NNP cord-262511-96xp1v0r 208 16 - - HYPH cord-262511-96xp1v0r 208 17 processing process VBG cord-262511-96xp1v0r 208 18 pathway pathway NN cord-262511-96xp1v0r 208 19 . . . cord-262511-96xp1v0r 209 1 In in IN cord-262511-96xp1v0r 209 2 general general JJ cord-262511-96xp1v0r 209 3 , , , cord-262511-96xp1v0r 209 4 miRNAs miRNAs NNP cord-262511-96xp1v0r 209 5 are be VBP cord-262511-96xp1v0r 209 6 considered consider VBN cord-262511-96xp1v0r 209 7 post post JJ cord-262511-96xp1v0r 209 8 - - JJ cord-262511-96xp1v0r 209 9 transcriptional transcriptional JJ cord-262511-96xp1v0r 209 10 , , , cord-262511-96xp1v0r 209 11 negative negative JJ cord-262511-96xp1v0r 209 12 regulatory regulatory JJ cord-262511-96xp1v0r 209 13 elements element NNS cord-262511-96xp1v0r 209 14 , , , cord-262511-96xp1v0r 209 15 which which WDT cord-262511-96xp1v0r 209 16 have have VBP cord-262511-96xp1v0r 209 17 the the DT cord-262511-96xp1v0r 209 18 ability ability NN cord-262511-96xp1v0r 209 19 to to TO cord-262511-96xp1v0r 209 20 dampen dampen VB cord-262511-96xp1v0r 209 21 many many JJ cord-262511-96xp1v0r 209 22 biological biological JJ cord-262511-96xp1v0r 209 23 processes process NNS cord-262511-96xp1v0r 209 24 including include VBG cord-262511-96xp1v0r 209 25 innate innate JJ cord-262511-96xp1v0r 209 26 and and CC cord-262511-96xp1v0r 209 27 adaptive adaptive JJ cord-262511-96xp1v0r 209 28 immunity immunity NN cord-262511-96xp1v0r 209 29 . . . cord-262511-96xp1v0r 210 1 A a DT cord-262511-96xp1v0r 210 2 role role NN cord-262511-96xp1v0r 210 3 in in IN cord-262511-96xp1v0r 210 4 the the DT cord-262511-96xp1v0r 210 5 regulation regulation NN cord-262511-96xp1v0r 210 6 of of IN cord-262511-96xp1v0r 210 7 T T NNP cord-262511-96xp1v0r 210 8 cell cell NN cord-262511-96xp1v0r 210 9 development development NN cord-262511-96xp1v0r 210 10 has have VBZ cord-262511-96xp1v0r 210 11 been be VBN cord-262511-96xp1v0r 210 12 proposed propose VBN cord-262511-96xp1v0r 210 13 recently recently RB cord-262511-96xp1v0r 210 14 in in IN cord-262511-96xp1v0r 210 15 a a DT cord-262511-96xp1v0r 210 16 few few JJ cord-262511-96xp1v0r 210 17 studies study NNS cord-262511-96xp1v0r 210 18 [ [ -LRB- cord-262511-96xp1v0r 210 19 96 96 CD cord-262511-96xp1v0r 210 20 -99 -99 NN cord-262511-96xp1v0r 210 21 ] ] -RRB- cord-262511-96xp1v0r 210 22 . . . cord-262511-96xp1v0r 211 1 Specific specific JJ cord-262511-96xp1v0r 211 2 deletion deletion NN cord-262511-96xp1v0r 211 3 of of IN cord-262511-96xp1v0r 211 4 the the DT cord-262511-96xp1v0r 211 5 dicer dicer NN cord-262511-96xp1v0r 211 6 - - HYPH cord-262511-96xp1v0r 211 7 coding code VBG cord-262511-96xp1v0r 211 8 gene gene NN cord-262511-96xp1v0r 211 9 , , , cord-262511-96xp1v0r 211 10 dcr-1 dcr-1 NNP cord-262511-96xp1v0r 211 11 , , , cord-262511-96xp1v0r 211 12 in in IN cord-262511-96xp1v0r 211 13 mouse mouse NN cord-262511-96xp1v0r 211 14 T T NNP cord-262511-96xp1v0r 211 15 cell cell NN cord-262511-96xp1v0r 211 16 lineage lineage NN cord-262511-96xp1v0r 211 17 resulted result VBD cord-262511-96xp1v0r 211 18 in in IN cord-262511-96xp1v0r 211 19 aberrant aberrant JJ cord-262511-96xp1v0r 211 20 Th Th NNP cord-262511-96xp1v0r 211 21 cell cell NN cord-262511-96xp1v0r 211 22 differentiation differentiation NN cord-262511-96xp1v0r 211 23 and and CC cord-262511-96xp1v0r 211 24 failure failure NN cord-262511-96xp1v0r 211 25 to to TO cord-262511-96xp1v0r 211 26 suppress suppress VB cord-262511-96xp1v0r 211 27 IFN- IFN- NNP cord-262511-96xp1v0r 211 28 ␥ ␥ CD cord-262511-96xp1v0r 211 29 expression expression NN cord-262511-96xp1v0r 211 30 under under IN cord-262511-96xp1v0r 211 31 Th2-polarizing Th2-polarizing NNP cord-262511-96xp1v0r 211 32 conditions condition NNS cord-262511-96xp1v0r 211 33 [ [ -LRB- cord-262511-96xp1v0r 211 34 98 98 CD cord-262511-96xp1v0r 211 35 ] ] -RRB- cord-262511-96xp1v0r 211 36 . . . cord-262511-96xp1v0r 212 1 Although although IN cord-262511-96xp1v0r 212 2 no no DT cord-262511-96xp1v0r 212 3 mechanism mechanism NN cord-262511-96xp1v0r 212 4 is be VBZ cord-262511-96xp1v0r 212 5 discussed discuss VBN cord-262511-96xp1v0r 212 6 in in IN cord-262511-96xp1v0r 212 7 this this DT cord-262511-96xp1v0r 212 8 study study NN cord-262511-96xp1v0r 212 9 , , , cord-262511-96xp1v0r 212 10 it -PRON- PRP cord-262511-96xp1v0r 212 11 is be VBZ cord-262511-96xp1v0r 212 12 possible possible JJ cord-262511-96xp1v0r 212 13 that that IN cord-262511-96xp1v0r 212 14 miRNA miRNA NNP cord-262511-96xp1v0r 212 15 targets target VBZ cord-262511-96xp1v0r 212 16 the the DT cord-262511-96xp1v0r 212 17 IFN- IFN- NNP cord-262511-96xp1v0r 212 18 ␥ ␥ NNP cord-262511-96xp1v0r 212 19 mRNA mRNA NNP cord-262511-96xp1v0r 212 20 , , , cord-262511-96xp1v0r 212 21 which which WDT cord-262511-96xp1v0r 212 22 harbors harbor VBZ cord-262511-96xp1v0r 212 23 an an DT cord-262511-96xp1v0r 212 24 ARE ARE NNS cord-262511-96xp1v0r 212 25 , , , cord-262511-96xp1v0r 212 26 which which WDT cord-262511-96xp1v0r 212 27 may may MD cord-262511-96xp1v0r 212 28 in in IN cord-262511-96xp1v0r 212 29 turn turn NN cord-262511-96xp1v0r 212 30 be be VB cord-262511-96xp1v0r 212 31 a a DT cord-262511-96xp1v0r 212 32 target target NN cord-262511-96xp1v0r 212 33 for for IN cord-262511-96xp1v0r 212 34 miR16 miR16 NNP cord-262511-96xp1v0r 212 35 by by IN cord-262511-96xp1v0r 212 36 a a DT cord-262511-96xp1v0r 212 37 process process NN cord-262511-96xp1v0r 212 38 in in IN cord-262511-96xp1v0r 212 39 which which WDT cord-262511-96xp1v0r 212 40 TTP TTP NNP cord-262511-96xp1v0r 212 41 promotes promote VBZ cord-262511-96xp1v0r 212 42 mRNA mRNA NNP cord-262511-96xp1v0r 212 43 decay decay NN cord-262511-96xp1v0r 212 44 . . . cord-262511-96xp1v0r 213 1 Involvement involvement NN cord-262511-96xp1v0r 213 2 of of IN cord-262511-96xp1v0r 213 3 miRNA miRNA NNP cord-262511-96xp1v0r 213 4 in in IN cord-262511-96xp1v0r 213 5 AREmediated aremediated JJ cord-262511-96xp1v0r 213 6 instability instability NN cord-262511-96xp1v0r 213 7 has have VBZ cord-262511-96xp1v0r 213 8 been be VBN cord-262511-96xp1v0r 213 9 documented document VBN cord-262511-96xp1v0r 213 10 by by IN cord-262511-96xp1v0r 213 11 demonstrating demonstrate VBG cord-262511-96xp1v0r 213 12 that that DT cord-262511-96xp1v0r 213 13 dicer dicer NN cord-262511-96xp1v0r 213 14 and and CC cord-262511-96xp1v0r 213 15 miR16 miR16 NNP cord-262511-96xp1v0r 213 16 are be VBP cord-262511-96xp1v0r 213 17 required require VBN cord-262511-96xp1v0r 213 18 in in IN cord-262511-96xp1v0r 213 19 epithelial epithelial JJ cord-262511-96xp1v0r 213 20 cells cell NNS cord-262511-96xp1v0r 213 21 [ [ -LRB- cord-262511-96xp1v0r 213 22 100 100 CD cord-262511-96xp1v0r 213 23 ] ] -RRB- cord-262511-96xp1v0r 213 24 . . . cord-262511-96xp1v0r 214 1 This this DT cord-262511-96xp1v0r 214 2 TTP TTP NNP cord-262511-96xp1v0r 214 3 involvement involvement NN cord-262511-96xp1v0r 214 4 would would MD cord-262511-96xp1v0r 214 5 be be VB cord-262511-96xp1v0r 214 6 an an DT cord-262511-96xp1v0r 214 7 attractive attractive JJ cord-262511-96xp1v0r 214 8 option option NN cord-262511-96xp1v0r 214 9 in in IN cord-262511-96xp1v0r 214 10 explaining explain VBG cord-262511-96xp1v0r 214 11 the the DT cord-262511-96xp1v0r 214 12 IFN- IFN- NNP cord-262511-96xp1v0r 214 13 ␥ ␥ NNP cord-262511-96xp1v0r 214 14 mRNA mrna NN cord-262511-96xp1v0r 214 15 dysregulation dysregulation NN cord-262511-96xp1v0r 214 16 in in IN cord-262511-96xp1v0r 214 17 dicer dicer NN cord-262511-96xp1v0r 214 18 - - HYPH cord-262511-96xp1v0r 214 19 deficient deficient JJ cord-262511-96xp1v0r 214 20 Th Th NNP cord-262511-96xp1v0r 214 21 cells cell NNS cord-262511-96xp1v0r 214 22 . . . cord-262511-96xp1v0r 215 1 Another another DT cord-262511-96xp1v0r 215 2 important important JJ cord-262511-96xp1v0r 215 3 role role NN cord-262511-96xp1v0r 215 4 of of IN cord-262511-96xp1v0r 215 5 dicer dicer NN cord-262511-96xp1v0r 215 6 in in IN cord-262511-96xp1v0r 215 7 T T NNP cord-262511-96xp1v0r 215 8 cell cell NN cord-262511-96xp1v0r 215 9 development development NN cord-262511-96xp1v0r 215 10 has have VBZ cord-262511-96xp1v0r 215 11 been be VBN cord-262511-96xp1v0r 215 12 shown show VBN cord-262511-96xp1v0r 215 13 to to TO cord-262511-96xp1v0r 215 14 occur occur VB cord-262511-96xp1v0r 215 15 in in IN cord-262511-96xp1v0r 215 16 the the DT cord-262511-96xp1v0r 215 17 development development NN cord-262511-96xp1v0r 215 18 of of IN cord-262511-96xp1v0r 215 19 regulatory regulatory JJ cord-262511-96xp1v0r 215 20 T t NN cord-262511-96xp1v0r 215 21 cells cell NNS cord-262511-96xp1v0r 215 22 ( ( -LRB- cord-262511-96xp1v0r 215 23 Treg Treg NNP cord-262511-96xp1v0r 215 24 ) ) -RRB- cord-262511-96xp1v0r 215 25 ; ; : cord-262511-96xp1v0r 215 26 absence absence NN cord-262511-96xp1v0r 215 27 of of IN cord-262511-96xp1v0r 215 28 dicer dicer NN cord-262511-96xp1v0r 215 29 leads lead VBZ cord-262511-96xp1v0r 215 30 to to IN cord-262511-96xp1v0r 215 31 a a DT cord-262511-96xp1v0r 215 32 reduced reduce VBN cord-262511-96xp1v0r 215 33 number number NN cord-262511-96xp1v0r 215 34 of of IN cord-262511-96xp1v0r 215 35 Treg Treg NNP cord-262511-96xp1v0r 215 36 and and CC cord-262511-96xp1v0r 215 37 immunopathological immunopathological JJ cord-262511-96xp1v0r 215 38 disorders disorder NNS cord-262511-96xp1v0r 215 39 such such JJ cord-262511-96xp1v0r 215 40 as as IN cord-262511-96xp1v0r 215 41 splenomegaly splenomegaly NN cord-262511-96xp1v0r 215 42 [ [ -LRB- cord-262511-96xp1v0r 215 43 97 97 CD cord-262511-96xp1v0r 215 44 ] ] -RRB- cord-262511-96xp1v0r 215 45 . . . cord-262511-96xp1v0r 216 1 This this DT cord-262511-96xp1v0r 216 2 study study NN cord-262511-96xp1v0r 216 3 concludes conclude VBZ cord-262511-96xp1v0r 216 4 that that IN cord-262511-96xp1v0r 216 5 dicer dicer NN cord-262511-96xp1v0r 216 6 facilitates facilitate VBZ cord-262511-96xp1v0r 216 7 the the DT cord-262511-96xp1v0r 216 8 development development NN cord-262511-96xp1v0r 216 9 of of IN cord-262511-96xp1v0r 216 10 Treg Treg NNP cord-262511-96xp1v0r 216 11 in in IN cord-262511-96xp1v0r 216 12 the the DT cord-262511-96xp1v0r 216 13 thymus thymus NN cord-262511-96xp1v0r 216 14 and and CC cord-262511-96xp1v0r 216 15 the the DT cord-262511-96xp1v0r 216 16 efficient efficient JJ cord-262511-96xp1v0r 216 17 induction induction NN cord-262511-96xp1v0r 216 18 of of IN cord-262511-96xp1v0r 216 19 the the DT cord-262511-96xp1v0r 216 20 necessary necessary JJ cord-262511-96xp1v0r 216 21 forkhead forkhead NN cord-262511-96xp1v0r 216 22 transcription transcription NN cord-262511-96xp1v0r 216 23 factor factor NN cord-262511-96xp1v0r 216 24 , , , cord-262511-96xp1v0r 216 25 Foxp3 foxp3 JJ cord-262511-96xp1v0r 216 26 , , , cord-262511-96xp1v0r 216 27 by by IN cord-262511-96xp1v0r 216 28 TGF- TGF- NNP cord-262511-96xp1v0r 216 29 ␤ ␤ NNP cord-262511-96xp1v0r 216 30 in in IN cord-262511-96xp1v0r 216 31 naive naive JJ cord-262511-96xp1v0r 216 32 CD4 CD4 NNP cord-262511-96xp1v0r 216 33 T T NNP cord-262511-96xp1v0r 216 34 cells cell NNS cord-262511-96xp1v0r 216 35 [ [ -LRB- cord-262511-96xp1v0r 216 36 97 97 CD cord-262511-96xp1v0r 216 37 ] ] -RRB- cord-262511-96xp1v0r 216 38 . . . cord-262511-96xp1v0r 217 1 Several several JJ cord-262511-96xp1v0r 217 2 miRNAs miRNAs NNP cord-262511-96xp1v0r 217 3 , , , cord-262511-96xp1v0r 217 4 miR146a miR146a NNP cord-262511-96xp1v0r 217 5 / / SYM cord-262511-96xp1v0r 217 6 b b NN cord-262511-96xp1v0r 217 7 , , , cord-262511-96xp1v0r 217 8 miR132 mir132 CD cord-262511-96xp1v0r 217 9 , , , cord-262511-96xp1v0r 217 10 and and CC cord-262511-96xp1v0r 217 11 miR155 mir155 CD cord-262511-96xp1v0r 217 12 , , , cord-262511-96xp1v0r 217 13 are be VBP cord-262511-96xp1v0r 217 14 LPS LPS NNP cord-262511-96xp1v0r 217 15 - - HYPH cord-262511-96xp1v0r 217 16 responsive responsive JJ cord-262511-96xp1v0r 217 17 genes gene NNS cord-262511-96xp1v0r 217 18 in in IN cord-262511-96xp1v0r 217 19 human human JJ cord-262511-96xp1v0r 217 20 monocytes monocyte NNS cord-262511-96xp1v0r 217 21 [ [ -LRB- cord-262511-96xp1v0r 217 22 99 99 CD cord-262511-96xp1v0r 217 23 , , , cord-262511-96xp1v0r 217 24 101 101 CD cord-262511-96xp1v0r 217 25 ] ] -RRB- cord-262511-96xp1v0r 217 26 . . . cord-262511-96xp1v0r 218 1 The the DT cord-262511-96xp1v0r 218 2 miR155 mir155 CD cord-262511-96xp1v0r 218 3 is be VBZ cord-262511-96xp1v0r 218 4 inducible inducible JJ cord-262511-96xp1v0r 218 5 in in IN cord-262511-96xp1v0r 218 6 a a DT cord-262511-96xp1v0r 218 7 human human JJ cord-262511-96xp1v0r 218 8 primary primary JJ cord-262511-96xp1v0r 218 9 macrophage macrophage NN cord-262511-96xp1v0r 218 10 in in IN cord-262511-96xp1v0r 218 11 response response NN cord-262511-96xp1v0r 218 12 to to IN cord-262511-96xp1v0r 218 13 different different JJ cord-262511-96xp1v0r 218 14 types type NNS cord-262511-96xp1v0r 218 15 of of IN cord-262511-96xp1v0r 218 16 inflammatory inflammatory JJ cord-262511-96xp1v0r 218 17 mediators mediator NNS cord-262511-96xp1v0r 218 18 [ [ -LRB- cord-262511-96xp1v0r 218 19 101 101 CD cord-262511-96xp1v0r 218 20 ] ] -RRB- cord-262511-96xp1v0r 218 21 , , , cord-262511-96xp1v0r 218 22 but but CC cord-262511-96xp1v0r 218 23 its -PRON- PRP$ cord-262511-96xp1v0r 218 24 effects effect NNS cord-262511-96xp1v0r 218 25 on on IN cord-262511-96xp1v0r 218 26 the the DT cord-262511-96xp1v0r 218 27 immune immune JJ cord-262511-96xp1v0r 218 28 cell cell NN cord-262511-96xp1v0r 218 29 function function NN cord-262511-96xp1v0r 218 30 remain remain VBP cord-262511-96xp1v0r 218 31 to to TO cord-262511-96xp1v0r 218 32 be be VB cord-262511-96xp1v0r 218 33 elucidated elucidate VBN cord-262511-96xp1v0r 218 34 . . . cord-262511-96xp1v0r 219 1 The the DT cord-262511-96xp1v0r 219 2 miR146a miR146a NNPS cord-262511-96xp1v0r 219 3 / / SYM cord-262511-96xp1v0r 219 4 b b TO cord-262511-96xp1v0r 219 5 bind bind VB cord-262511-96xp1v0r 219 6 sequences sequence NNS cord-262511-96xp1v0r 219 7 in in IN cord-262511-96xp1v0r 219 8 the the DT cord-262511-96xp1v0r 219 9 3ЈUTRs 3јutrs CD cord-262511-96xp1v0r 219 10 of of IN cord-262511-96xp1v0r 219 11 two two CD cord-262511-96xp1v0r 219 12 important important JJ cord-262511-96xp1v0r 219 13 adaptor adaptor NN cord-262511-96xp1v0r 219 14 molecules molecule NNS cord-262511-96xp1v0r 219 15 involved involve VBN cord-262511-96xp1v0r 219 16 in in IN cord-262511-96xp1v0r 219 17 LPS LPS NNP cord-262511-96xp1v0r 219 18 signaling signal VBG cord-262511-96xp1v0r 219 19 , , , cord-262511-96xp1v0r 219 20 TRAF6 TRAF6 NNP cord-262511-96xp1v0r 219 21 and and CC cord-262511-96xp1v0r 219 22 IRAK1 IRAK1 NNP cord-262511-96xp1v0r 219 23 , , , cord-262511-96xp1v0r 219 24 and and CC cord-262511-96xp1v0r 219 25 these these DT cord-262511-96xp1v0r 219 26 UTRs utr NNS cord-262511-96xp1v0r 219 27 inhibit inhibit VBP cord-262511-96xp1v0r 219 28 expression expression NN cord-262511-96xp1v0r 219 29 of of IN cord-262511-96xp1v0r 219 30 reporter reporter NN cord-262511-96xp1v0r 219 31 constructs construct NNS cord-262511-96xp1v0r 219 32 [ [ -LRB- cord-262511-96xp1v0r 219 33 99 99 CD cord-262511-96xp1v0r 219 34 ] ] -RRB- cord-262511-96xp1v0r 219 35 . . . cord-262511-96xp1v0r 220 1 The the DT cord-262511-96xp1v0r 220 2 role role NN cord-262511-96xp1v0r 220 3 of of IN cord-262511-96xp1v0r 220 4 miRNA miRNA NNP cord-262511-96xp1v0r 220 5 silencing silence VBG cord-262511-96xp1v0r 220 6 machinery machinery NN cord-262511-96xp1v0r 220 7 in in IN cord-262511-96xp1v0r 220 8 not not RB cord-262511-96xp1v0r 220 9 limited limited JJ cord-262511-96xp1v0r 220 10 to to IN cord-262511-96xp1v0r 220 11 negative negative JJ cord-262511-96xp1v0r 220 12 control control NN cord-262511-96xp1v0r 220 13 of of IN cord-262511-96xp1v0r 220 14 the the DT cord-262511-96xp1v0r 220 15 immune immune JJ cord-262511-96xp1v0r 220 16 system system NN cord-262511-96xp1v0r 220 17 as as IN cord-262511-96xp1v0r 220 18 described describe VBN cord-262511-96xp1v0r 220 19 in in IN cord-262511-96xp1v0r 220 20 the the DT cord-262511-96xp1v0r 220 21 above above JJ cord-262511-96xp1v0r 220 22 examples example NNS cord-262511-96xp1v0r 220 23 but but CC cord-262511-96xp1v0r 220 24 itself -PRON- PRP cord-262511-96xp1v0r 220 25 , , , cord-262511-96xp1v0r 220 26 has have VBZ cord-262511-96xp1v0r 220 27 a a DT cord-262511-96xp1v0r 220 28 direct direct JJ cord-262511-96xp1v0r 220 29 innate innate JJ cord-262511-96xp1v0r 220 30 immunity immunity NN cord-262511-96xp1v0r 220 31 function function NN cord-262511-96xp1v0r 220 32 . . . cord-262511-96xp1v0r 221 1 Drosha Drosha NNP cord-262511-96xp1v0r 221 2 and and CC cord-262511-96xp1v0r 221 3 dicer dicer NN cord-262511-96xp1v0r 221 4 can can MD cord-262511-96xp1v0r 221 5 act act VB cord-262511-96xp1v0r 221 6 as as RB cord-262511-96xp1v0r 221 7 intracellular intracellular JJ cord-262511-96xp1v0r 221 8 , , , cord-262511-96xp1v0r 221 9 antiviral antiviral JJ cord-262511-96xp1v0r 221 10 enzymes enzyme NNS cord-262511-96xp1v0r 221 11 against against IN cord-262511-96xp1v0r 221 12 HIV HIV NNP cord-262511-96xp1v0r 221 13 human human JJ cord-262511-96xp1v0r 221 14 monocytic monocytic JJ cord-262511-96xp1v0r 221 15 cells cell NNS cord-262511-96xp1v0r 221 16 , , , cord-262511-96xp1v0r 221 17 and and CC cord-262511-96xp1v0r 221 18 the the DT cord-262511-96xp1v0r 221 19 HIV HIV NNP cord-262511-96xp1v0r 221 20 Tat Tat NNP cord-262511-96xp1v0r 221 21 can can MD cord-262511-96xp1v0r 221 22 act act VB cord-262511-96xp1v0r 221 23 as as IN cord-262511-96xp1v0r 221 24 a a DT cord-262511-96xp1v0r 221 25 suppressor suppressor NN cord-262511-96xp1v0r 221 26 of of IN cord-262511-96xp1v0r 221 27 the the DT cord-262511-96xp1v0r 221 28 host host NN cord-262511-96xp1v0r 221 29 RNA RNA NNP cord-262511-96xp1v0r 221 30 silencing silence VBG cord-262511-96xp1v0r 221 31 [ [ -LRB- cord-262511-96xp1v0r 221 32 102 102 CD cord-262511-96xp1v0r 221 33 , , , cord-262511-96xp1v0r 221 34 103 103 CD cord-262511-96xp1v0r 221 35 ] ] -RRB- cord-262511-96xp1v0r 221 36 . . . cord-262511-96xp1v0r 222 1 Although although IN cord-262511-96xp1v0r 222 2 many many JJ cord-262511-96xp1v0r 222 3 recent recent JJ cord-262511-96xp1v0r 222 4 studies study NNS cord-262511-96xp1v0r 222 5 emphasize emphasize VBP cord-262511-96xp1v0r 222 6 protein protein NN cord-262511-96xp1v0r 222 7 - - HYPH cord-262511-96xp1v0r 222 8 protein protein NN cord-262511-96xp1v0r 222 9 and and CC cord-262511-96xp1v0r 222 10 the the DT cord-262511-96xp1v0r 222 11 adaptor adaptor NN cord-262511-96xp1v0r 222 12 interactions interaction NNS cord-262511-96xp1v0r 222 13 on on IN cord-262511-96xp1v0r 222 14 signaling signal VBG cord-262511-96xp1v0r 222 15 events event NNS cord-262511-96xp1v0r 222 16 , , , cord-262511-96xp1v0r 222 17 which which WDT cord-262511-96xp1v0r 222 18 lead lead VBP cord-262511-96xp1v0r 222 19 to to IN cord-262511-96xp1v0r 222 20 transcriptional transcriptional JJ cord-262511-96xp1v0r 222 21 activation activation NN cord-262511-96xp1v0r 222 22 , , , cord-262511-96xp1v0r 222 23 it -PRON- PRP cord-262511-96xp1v0r 222 24 is be VBZ cord-262511-96xp1v0r 222 25 expected expect VBN cord-262511-96xp1v0r 222 26 that that IN cord-262511-96xp1v0r 222 27 more more JJR cord-262511-96xp1v0r 222 28 studies study NNS cord-262511-96xp1v0r 222 29 will will MD cord-262511-96xp1v0r 222 30 focus focus VB cord-262511-96xp1v0r 222 31 on on IN cord-262511-96xp1v0r 222 32 post post JJ cord-262511-96xp1v0r 222 33 - - JJ cord-262511-96xp1v0r 222 34 transcriptional transcriptional JJ cord-262511-96xp1v0r 222 35 mechanisms mechanism NNS cord-262511-96xp1v0r 222 36 . . . cord-262511-96xp1v0r 223 1 The the DT cord-262511-96xp1v0r 223 2 array array NN cord-262511-96xp1v0r 223 3 of of IN cord-262511-96xp1v0r 223 4 intracellular intracellular JJ cord-262511-96xp1v0r 223 5 RNA rna NN cord-262511-96xp1v0r 223 6 - - HYPH cord-262511-96xp1v0r 223 7 protein protein NN cord-262511-96xp1v0r 223 8 interactions interaction NNS cord-262511-96xp1v0r 223 9 is be VBZ cord-262511-96xp1v0r 223 10 manifested manifest VBN cord-262511-96xp1v0r 223 11 by by IN cord-262511-96xp1v0r 223 12 the the DT cord-262511-96xp1v0r 223 13 large large JJ cord-262511-96xp1v0r 223 14 number number NN cord-262511-96xp1v0r 223 15 of of IN cord-262511-96xp1v0r 223 16 ARE are VBP cord-262511-96xp1v0r 223 17 - - : cord-262511-96xp1v0r 223 18 mRNAs mRNAs NNPS cord-262511-96xp1v0r 223 19 and and CC cord-262511-96xp1v0r 223 20 RNA RNA NNP cord-262511-96xp1v0r 223 21 - - HYPH cord-262511-96xp1v0r 223 22 binding bind VBG cord-262511-96xp1v0r 223 23 proteins protein NNS cord-262511-96xp1v0r 223 24 . . . cord-262511-96xp1v0r 224 1 Given give VBN cord-262511-96xp1v0r 224 2 that that IN cord-262511-96xp1v0r 224 3 many many JJ cord-262511-96xp1v0r 224 4 mRNAs mrna NNS cord-262511-96xp1v0r 224 5 of of IN cord-262511-96xp1v0r 224 6 the the DT cord-262511-96xp1v0r 224 7 immune immune JJ cord-262511-96xp1v0r 224 8 response response NN cord-262511-96xp1v0r 224 9 contain contain VBP cord-262511-96xp1v0r 224 10 AREs are NNS cord-262511-96xp1v0r 224 11 , , , cord-262511-96xp1v0r 224 12 and and CC cord-262511-96xp1v0r 224 13 multiple multiple JJ cord-262511-96xp1v0r 224 14 signaling signal VBG cord-262511-96xp1v0r 224 15 pathways pathway NNS cord-262511-96xp1v0r 224 16 are be VBP cord-262511-96xp1v0r 224 17 operative operative JJ cord-262511-96xp1v0r 224 18 such such JJ cord-262511-96xp1v0r 224 19 as as IN cord-262511-96xp1v0r 224 20 p38 p38 CD cord-262511-96xp1v0r 224 21 MAPK MAPK NNP cord-262511-96xp1v0r 224 22 and and CC cord-262511-96xp1v0r 224 23 PI-3K PI-3K NNP cord-262511-96xp1v0r 224 24 / / SYM cord-262511-96xp1v0r 224 25 AKT AKT NNP cord-262511-96xp1v0r 224 26 , , , cord-262511-96xp1v0r 224 27 one one PRP cord-262511-96xp1v0r 224 28 can can MD cord-262511-96xp1v0r 224 29 imagine imagine VB cord-262511-96xp1v0r 224 30 the the DT cord-262511-96xp1v0r 224 31 vast vast JJ cord-262511-96xp1v0r 224 32 probability probability NN cord-262511-96xp1v0r 224 33 of of IN cord-262511-96xp1v0r 224 34 posttranscriptional posttranscriptional JJ cord-262511-96xp1v0r 224 35 interactions interaction NNS cord-262511-96xp1v0r 224 36 in in IN cord-262511-96xp1v0r 224 37 the the DT cord-262511-96xp1v0r 224 38 immune immune JJ cord-262511-96xp1v0r 224 39 system system NN cord-262511-96xp1v0r 224 40 . . . cord-262511-96xp1v0r 225 1 Additional additional JJ cord-262511-96xp1v0r 225 2 types type NNS cord-262511-96xp1v0r 225 3 of of IN cord-262511-96xp1v0r 225 4 post post JJ cord-262511-96xp1v0r 225 5 - - JJ cord-262511-96xp1v0r 225 6 transcriptional transcriptional JJ cord-262511-96xp1v0r 225 7 mechanisms mechanism NNS cord-262511-96xp1v0r 225 8 , , , cord-262511-96xp1v0r 225 9 such such JJ cord-262511-96xp1v0r 225 10 as as IN cord-262511-96xp1v0r 225 11 alternative alternative JJ cord-262511-96xp1v0r 225 12 splicing splicing NN cord-262511-96xp1v0r 225 13 and and CC cord-262511-96xp1v0r 225 14 post post JJ cord-262511-96xp1v0r 225 15 - - JJ cord-262511-96xp1v0r 225 16 translational translational JJ cord-262511-96xp1v0r 225 17 regulatory regulatory JJ cord-262511-96xp1v0r 225 18 events event NNS cord-262511-96xp1v0r 225 19 , , , cord-262511-96xp1v0r 225 20 although although IN cord-262511-96xp1v0r 225 21 not not RB cord-262511-96xp1v0r 225 22 within within IN cord-262511-96xp1v0r 225 23 the the DT cord-262511-96xp1v0r 225 24 focus focus NN cord-262511-96xp1v0r 225 25 of of IN cord-262511-96xp1v0r 225 26 this this DT cord-262511-96xp1v0r 225 27 review review NN cord-262511-96xp1v0r 225 28 , , , cord-262511-96xp1v0r 225 29 also also RB cord-262511-96xp1v0r 225 30 contribute contribute VB cord-262511-96xp1v0r 225 31 to to IN cord-262511-96xp1v0r 225 32 the the DT cord-262511-96xp1v0r 225 33 intricate intricate JJ cord-262511-96xp1v0r 225 34 and and CC cord-262511-96xp1v0r 225 35 complex complex JJ cord-262511-96xp1v0r 225 36 regulation regulation NN cord-262511-96xp1v0r 225 37 of of IN cord-262511-96xp1v0r 225 38 the the DT cord-262511-96xp1v0r 225 39 immune immune JJ cord-262511-96xp1v0r 225 40 system system NN cord-262511-96xp1v0r 225 41 . . . cord-262511-96xp1v0r 226 1 As as IN cord-262511-96xp1v0r 226 2 cities city NNS cord-262511-96xp1v0r 226 3 cope cope VBP cord-262511-96xp1v0r 226 4 with with IN cord-262511-96xp1v0r 226 5 the the DT cord-262511-96xp1v0r 226 6 rapid rapid JJ cord-262511-96xp1v0r 226 7 entry entry NN cord-262511-96xp1v0r 226 8 of of IN cord-262511-96xp1v0r 226 9 people people NNS cord-262511-96xp1v0r 226 10 by by IN cord-262511-96xp1v0r 226 11 using use VBG cord-262511-96xp1v0r 226 12 rapid rapid JJ cord-262511-96xp1v0r 226 13 transit transit NN cord-262511-96xp1v0r 226 14 systems system NNS cord-262511-96xp1v0r 226 15 , , , cord-262511-96xp1v0r 226 16 post post JJ cord-262511-96xp1v0r 226 17 - - JJ cord-262511-96xp1v0r 226 18 transcriptional transcriptional JJ cord-262511-96xp1v0r 226 19 control control NN cord-262511-96xp1v0r 226 20 of of IN cord-262511-96xp1v0r 226 21 immune immune JJ cord-262511-96xp1v0r 226 22 system system NN cord-262511-96xp1v0r 226 23 helps help VBZ cord-262511-96xp1v0r 226 24 in in IN cord-262511-96xp1v0r 226 25 rapid rapid JJ cord-262511-96xp1v0r 226 26 activation activation NN cord-262511-96xp1v0r 226 27 of of IN cord-262511-96xp1v0r 226 28 immune immune JJ cord-262511-96xp1v0r 226 29 cells cell NNS cord-262511-96xp1v0r 226 30 by by IN cord-262511-96xp1v0r 226 31 mechanisms mechanism NNS cord-262511-96xp1v0r 226 32 that that WDT cord-262511-96xp1v0r 226 33 involve involve VBP cord-262511-96xp1v0r 226 34 rapid rapid JJ cord-262511-96xp1v0r 226 35 translocation translocation NN cord-262511-96xp1v0r 226 36 of of IN cord-262511-96xp1v0r 226 37 mRNA mRNA NNP cord-262511-96xp1v0r 226 38 stabilization stabilization NN cord-262511-96xp1v0r 226 39 proteins protein NNS cord-262511-96xp1v0r 226 40 such such JJ cord-262511-96xp1v0r 226 41 as as IN cord-262511-96xp1v0r 226 42 HuR hur NN cord-262511-96xp1v0r 226 43 to to TO cord-262511-96xp1v0r 226 44 effector effector VB cord-262511-96xp1v0r 226 45 cellular cellular JJ cord-262511-96xp1v0r 226 46 compartments compartment NNS cord-262511-96xp1v0r 226 47 and/or and/or CC cord-262511-96xp1v0r 226 48 temporal temporal JJ cord-262511-96xp1v0r 226 49 inactivation inactivation NN cord-262511-96xp1v0r 226 50 , , , cord-262511-96xp1v0r 227 1 e.g. e.g. RB cord-262511-96xp1v0r 227 2 , , , cord-262511-96xp1v0r 227 3 by by IN cord-262511-96xp1v0r 227 4 phosphorylation phosphorylation NN cord-262511-96xp1v0r 227 5 or or CC cord-262511-96xp1v0r 227 6 proteolysis proteolysis NN cord-262511-96xp1v0r 227 7 of of IN cord-262511-96xp1v0r 227 8 RNA RNA NNP cord-262511-96xp1v0r 227 9 decay decay NN cord-262511-96xp1v0r 227 10 proteins protein NNS cord-262511-96xp1v0r 227 11 such such JJ cord-262511-96xp1v0r 227 12 as as IN cord-262511-96xp1v0r 227 13 TTP TTP NNP cord-262511-96xp1v0r 227 14 or or CC cord-262511-96xp1v0r 227 15 KSRP KSRP NNP cord-262511-96xp1v0r 227 16 . . . cord-262511-96xp1v0r 228 1 Also also RB cord-262511-96xp1v0r 228 2 , , , cord-262511-96xp1v0r 228 3 when when WRB cord-262511-96xp1v0r 228 4 people people NNS cord-262511-96xp1v0r 228 5 move move VBP cord-262511-96xp1v0r 228 6 out out RB cord-262511-96xp1v0r 228 7 quickly quickly RB cord-262511-96xp1v0r 228 8 from from IN cord-262511-96xp1v0r 228 9 the the DT cord-262511-96xp1v0r 228 10 transits transit NNS cord-262511-96xp1v0r 228 11 at at IN cord-262511-96xp1v0r 228 12 the the DT cord-262511-96xp1v0r 228 13 point point NN cord-262511-96xp1v0r 228 14 of of IN cord-262511-96xp1v0r 228 15 exit exit NN cord-262511-96xp1v0r 228 16 , , , cord-262511-96xp1v0r 228 17 mechanisms mechanism NNS cord-262511-96xp1v0r 228 18 in in IN cord-262511-96xp1v0r 228 19 the the DT cord-262511-96xp1v0r 228 20 immune immune JJ cord-262511-96xp1v0r 228 21 system system NN cord-262511-96xp1v0r 228 22 ensure ensure VBP cord-262511-96xp1v0r 228 23 a a DT cord-262511-96xp1v0r 228 24 swift swift JJ cord-262511-96xp1v0r 228 25 shut shut NN cord-262511-96xp1v0r 228 26 - - HYPH cord-262511-96xp1v0r 228 27 off off NN cord-262511-96xp1v0r 228 28 and and CC cord-262511-96xp1v0r 228 29 recovery recovery NN cord-262511-96xp1v0r 228 30 . . . cord-262511-96xp1v0r 229 1 This this DT cord-262511-96xp1v0r 229 2 happens happen VBZ cord-262511-96xp1v0r 229 3 by by IN cord-262511-96xp1v0r 229 4 the the DT cord-262511-96xp1v0r 229 5 reversal reversal NN cord-262511-96xp1v0r 229 6 of of IN cord-262511-96xp1v0r 229 7 events event NNS cord-262511-96xp1v0r 229 8 that that WDT cord-262511-96xp1v0r 229 9 led lead VBD cord-262511-96xp1v0r 229 10 to to IN cord-262511-96xp1v0r 229 11 mRNA mRNA NNP cord-262511-96xp1v0r 229 12 stabilization stabilization NN cord-262511-96xp1v0r 229 13 , , , cord-262511-96xp1v0r 229 14 activation activation NN cord-262511-96xp1v0r 229 15 of of IN cord-262511-96xp1v0r 229 16 decay decay NN cord-262511-96xp1v0r 229 17 - - HYPH cord-262511-96xp1v0r 229 18 promoting promote VBG cord-262511-96xp1v0r 229 19 proteins protein NNS cord-262511-96xp1v0r 229 20 , , , cord-262511-96xp1v0r 229 21 and and CC cord-262511-96xp1v0r 229 22 translational translational JJ cord-262511-96xp1v0r 229 23 arrest arrest NN cord-262511-96xp1v0r 229 24 ( ( -LRB- cord-262511-96xp1v0r 229 25 Fig Fig NNP cord-262511-96xp1v0r 229 26 . . . cord-262511-96xp1v0r 229 27 3 3 CD cord-262511-96xp1v0r 229 28 ) ) -RRB- cord-262511-96xp1v0r 229 29 . . . cord-262511-96xp1v0r 230 1 These these DT cord-262511-96xp1v0r 230 2 temporal temporal JJ cord-262511-96xp1v0r 230 3 and and CC cord-262511-96xp1v0r 230 4 spatial spatial JJ cord-262511-96xp1v0r 230 5 events event NNS cord-262511-96xp1v0r 230 6 culminate culminate VBP cord-262511-96xp1v0r 230 7 in in IN cord-262511-96xp1v0r 230 8 a a DT cord-262511-96xp1v0r 230 9 transiently transiently RB cord-262511-96xp1v0r 230 10 regulated regulate VBN cord-262511-96xp1v0r 230 11 immune immune JJ cord-262511-96xp1v0r 230 12 system system NN cord-262511-96xp1v0r 230 13 , , , cord-262511-96xp1v0r 230 14 which which WDT cord-262511-96xp1v0r 230 15 is be VBZ cord-262511-96xp1v0r 230 16 able able JJ cord-262511-96xp1v0r 230 17 to to TO cord-262511-96xp1v0r 230 18 cope cope VB cord-262511-96xp1v0r 230 19 with with IN cord-262511-96xp1v0r 230 20 external external JJ cord-262511-96xp1v0r 230 21 and and CC cord-262511-96xp1v0r 230 22 internal internal JJ cord-262511-96xp1v0r 230 23 insults insult NNS cord-262511-96xp1v0r 230 24 to to IN cord-262511-96xp1v0r 230 25 the the DT cord-262511-96xp1v0r 230 26 body body NN cord-262511-96xp1v0r 230 27 without without IN cord-262511-96xp1v0r 230 28 deleterious deleterious JJ cord-262511-96xp1v0r 230 29 effects effect NNS cord-262511-96xp1v0r 230 30 on on IN cord-262511-96xp1v0r 230 31 the the DT cord-262511-96xp1v0r 230 32 host host NN cord-262511-96xp1v0r 230 33 . . . cord-262511-96xp1v0r 231 1 Specific specific JJ cord-262511-96xp1v0r 231 2 abnormal abnormal JJ cord-262511-96xp1v0r 231 3 situations situation NNS cord-262511-96xp1v0r 231 4 may may MD cord-262511-96xp1v0r 231 5 arise arise VB cord-262511-96xp1v0r 231 6 if if IN cord-262511-96xp1v0r 231 7 the the DT cord-262511-96xp1v0r 231 8 transient transient JJ cord-262511-96xp1v0r 231 9 response response NN cord-262511-96xp1v0r 231 10 of of IN cord-262511-96xp1v0r 231 11 the the DT cord-262511-96xp1v0r 231 12 immune immune JJ cord-262511-96xp1v0r 231 13 system system NN cord-262511-96xp1v0r 231 14 becomes become VBZ cord-262511-96xp1v0r 231 15 prolonged prolong VBN cord-262511-96xp1v0r 231 16 , , , cord-262511-96xp1v0r 231 17 such such JJ cord-262511-96xp1v0r 231 18 as as IN cord-262511-96xp1v0r 231 19 those those DT cord-262511-96xp1v0r 231 20 that that WDT cord-262511-96xp1v0r 231 21 occur occur VBP cord-262511-96xp1v0r 231 22 in in IN cord-262511-96xp1v0r 231 23 chronic chronic JJ cord-262511-96xp1v0r 231 24 inflammatory inflammatory JJ cord-262511-96xp1v0r 231 25 and and CC cord-262511-96xp1v0r 231 26 autoimmune autoimmune JJ cord-262511-96xp1v0r 231 27 diseases disease NNS cord-262511-96xp1v0r 231 28 . . . cord-262511-96xp1v0r 232 1 Fig Fig NNP cord-262511-96xp1v0r 232 2 . . . cord-262511-96xp1v0r 233 1 3 3 LS cord-262511-96xp1v0r 233 2 . . . cord-262511-96xp1v0r 234 1 Rapid rapid JJ cord-262511-96xp1v0r 234 2 transit transit NN cord-262511-96xp1v0r 234 3 analogy analogy NN cord-262511-96xp1v0r 234 4 with with IN cord-262511-96xp1v0r 234 5 rapid rapid JJ cord-262511-96xp1v0r 234 6 activation activation NN cord-262511-96xp1v0r 234 7 and and CC cord-262511-96xp1v0r 234 8 repression repression NN cord-262511-96xp1v0r 234 9 of of IN cord-262511-96xp1v0r 234 10 gene gene NN cord-262511-96xp1v0r 234 11 expression expression NN cord-262511-96xp1v0r 234 12 . . . cord-262511-96xp1v0r 235 1 Receptor receptor NN cord-262511-96xp1v0r 235 2 - - HYPH cord-262511-96xp1v0r 235 3 mediated mediate VBN cord-262511-96xp1v0r 235 4 signaling signal VBG cord-262511-96xp1v0r 235 5 events event NNS cord-262511-96xp1v0r 235 6 following follow VBG cord-262511-96xp1v0r 235 7 recognition recognition NN cord-262511-96xp1v0r 235 8 of of IN cord-262511-96xp1v0r 235 9 various various JJ cord-262511-96xp1v0r 235 10 types type NNS cord-262511-96xp1v0r 235 11 of of IN cord-262511-96xp1v0r 235 12 foreign foreign JJ cord-262511-96xp1v0r 235 13 bodies body NNS cord-262511-96xp1v0r 235 14 or or CC cord-262511-96xp1v0r 235 15 following follow VBG cord-262511-96xp1v0r 235 16 interactions interaction NNS cord-262511-96xp1v0r 235 17 with with IN cord-262511-96xp1v0r 235 18 positive positive JJ cord-262511-96xp1v0r 235 19 and and CC cord-262511-96xp1v0r 235 20 negative negative JJ cord-262511-96xp1v0r 235 21 modulatory modulatory JJ cord-262511-96xp1v0r 235 22 cytokines cytokine NNS cord-262511-96xp1v0r 235 23 lead lead VBP cord-262511-96xp1v0r 235 24 to to IN cord-262511-96xp1v0r 235 25 transcriptional transcriptional JJ cord-262511-96xp1v0r 235 26 and and CC cord-262511-96xp1v0r 235 27 post post JJ cord-262511-96xp1v0r 235 28 - - JJ cord-262511-96xp1v0r 235 29 transcriptional transcriptional JJ cord-262511-96xp1v0r 235 30 activities activity NNS cord-262511-96xp1v0r 235 31 . . . cord-262511-96xp1v0r 236 1 Rapid rapid JJ cord-262511-96xp1v0r 236 2 activation activation NN cord-262511-96xp1v0r 236 3 of of IN cord-262511-96xp1v0r 236 4 immune immune JJ cord-262511-96xp1v0r 236 5 cells cell NNS cord-262511-96xp1v0r 236 6 and and CC cord-262511-96xp1v0r 237 1 early early JJ cord-262511-96xp1v0r 237 2 response response NN cord-262511-96xp1v0r 237 3 events event NNS cord-262511-96xp1v0r 237 4 such such JJ cord-262511-96xp1v0r 237 5 as as IN cord-262511-96xp1v0r 237 6 cytokine cytokine NN cord-262511-96xp1v0r 237 7 production production NN cord-262511-96xp1v0r 237 8 mimic mimic VBP cord-262511-96xp1v0r 237 9 rapid rapid JJ cord-262511-96xp1v0r 237 10 entry entry NN cord-262511-96xp1v0r 237 11 to to IN cord-262511-96xp1v0r 237 12 transit transit NN cord-262511-96xp1v0r 237 13 systems system NNS cord-262511-96xp1v0r 237 14 , , , cord-262511-96xp1v0r 237 15 culminating culminate VBG cord-262511-96xp1v0r 237 16 in in IN cord-262511-96xp1v0r 237 17 amplification amplification NN cord-262511-96xp1v0r 237 18 of of IN cord-262511-96xp1v0r 237 19 innate innate JJ cord-262511-96xp1v0r 237 20 and and CC cord-262511-96xp1v0r 237 21 adaptive adaptive JJ cord-262511-96xp1v0r 237 22 responses response NNS cord-262511-96xp1v0r 237 23 , , , cord-262511-96xp1v0r 237 24 whereas whereas IN cord-262511-96xp1v0r 237 25 rapid rapid JJ cord-262511-96xp1v0r 237 26 exit exit NN cord-262511-96xp1v0r 237 27 from from IN cord-262511-96xp1v0r 237 28 the the DT cord-262511-96xp1v0r 237 29 transit transit NN cord-262511-96xp1v0r 237 30 mimics mimic VBZ cord-262511-96xp1v0r 237 31 the the DT cord-262511-96xp1v0r 237 32 shut shut VBN cord-262511-96xp1v0r 237 33 - - HYPH cord-262511-96xp1v0r 237 34 off off RP cord-262511-96xp1v0r 237 35 mechanisms mechanism NNS cord-262511-96xp1v0r 237 36 in in IN cord-262511-96xp1v0r 237 37 the the DT cord-262511-96xp1v0r 237 38 immune immune JJ cord-262511-96xp1v0r 237 39 cells cell NNS cord-262511-96xp1v0r 237 40 that that WDT cord-262511-96xp1v0r 237 41 lead lead VBP cord-262511-96xp1v0r 237 42 to to IN cord-262511-96xp1v0r 237 43 transient transient JJ cord-262511-96xp1v0r 237 44 response response NN cord-262511-96xp1v0r 237 45 . . . cord-262511-96xp1v0r 238 1 This this DT cord-262511-96xp1v0r 238 2 is be VBZ cord-262511-96xp1v0r 238 3 orchestrated orchestrate VBN cord-262511-96xp1v0r 238 4 by by IN cord-262511-96xp1v0r 238 5 an an DT cord-262511-96xp1v0r 238 6 array array NN cord-262511-96xp1v0r 238 7 of of IN cord-262511-96xp1v0r 238 8 RNA RNA NNP cord-262511-96xp1v0r 238 9 decay decay NN cord-262511-96xp1v0r 238 10 mechanisms mechanism NNS cord-262511-96xp1v0r 238 11 and and CC cord-262511-96xp1v0r 238 12 a a DT cord-262511-96xp1v0r 238 13 vast vast JJ cord-262511-96xp1v0r 238 14 number number NN cord-262511-96xp1v0r 238 15 of of IN cord-262511-96xp1v0r 238 16 instability instability NN cord-262511-96xp1v0r 238 17 - - HYPH cord-262511-96xp1v0r 238 18 prone prone JJ cord-262511-96xp1v0r 238 19 mRNAs mrna NNS cord-262511-96xp1v0r 238 20 . . . cord-262511-96xp1v0r 239 1 PABP PABP NNP cord-262511-96xp1v0r 239 2 , , , cord-262511-96xp1v0r 239 3 Poly(A)-binding poly(a)-binde VBG cord-262511-96xp1v0r 239 4 protein protein NN cord-262511-96xp1v0r 239 5 ; ; : cord-262511-96xp1v0r 239 6 MLKs MLKs NNP cord-262511-96xp1v0r 239 7 , , , cord-262511-96xp1v0r 239 8 mixed mixed JJ cord-262511-96xp1v0r 239 9 lineage lineage NN cord-262511-96xp1v0r 239 10 kinases kinase NNS cord-262511-96xp1v0r 239 11 . . . cord-262511-96xp1v0r 240 1 ARED ARED NNP cord-262511-96xp1v0r 240 2 3.0 3.0 CD cord-262511-96xp1v0r 240 3 : : : cord-262511-96xp1v0r 240 4 the the DT cord-262511-96xp1v0r 240 5 large large JJ cord-262511-96xp1v0r 240 6 and and CC cord-262511-96xp1v0r 240 7 diverse diverse JJ cord-262511-96xp1v0r 240 8 AU au JJ cord-262511-96xp1v0r 240 9 - - HYPH cord-262511-96xp1v0r 240 10 rich rich JJ cord-262511-96xp1v0r 240 11 transcriptome transcriptome NN cord-262511-96xp1v0r 240 12 AU au NN cord-262511-96xp1v0r 240 13 - - HYPH cord-262511-96xp1v0r 240 14 rich rich JJ cord-262511-96xp1v0r 240 15 elements element NNS cord-262511-96xp1v0r 240 16 and and CC cord-262511-96xp1v0r 240 17 associated associated JJ cord-262511-96xp1v0r 240 18 factors factor NNS cord-262511-96xp1v0r 240 19 : : : cord-262511-96xp1v0r 240 20 are be VBP cord-262511-96xp1v0r 240 21 there there EX cord-262511-96xp1v0r 240 22 unifying unifying JJ cord-262511-96xp1v0r 240 23 principles principle NNS cord-262511-96xp1v0r 240 24 ? ? . cord-262511-96xp1v0r 241 1 Identification identification NN cord-262511-96xp1v0r 241 2 and and CC cord-262511-96xp1v0r 241 3 functional functional JJ cord-262511-96xp1v0r 241 4 outcome outcome NN cord-262511-96xp1v0r 241 5 of of IN cord-262511-96xp1v0r 241 6 mRNAs mrnas CD cord-262511-96xp1v0r 241 7 associated associate VBN cord-262511-96xp1v0r 241 8 with with IN cord-262511-96xp1v0r 241 9 RNAbinding rnabinde VBG cord-262511-96xp1v0r 241 10 protein protein NN cord-262511-96xp1v0r 242 1 TIA-1 tia-1 RB cord-262511-96xp1v0r 243 1 Novel Novel NNP cord-262511-96xp1v0r 243 2 mRNA mRNA NNP cord-262511-96xp1v0r 243 3 targets target NNS cord-262511-96xp1v0r 243 4 for for IN cord-262511-96xp1v0r 243 5 tristetraprolin tristetraprolin NNP cord-262511-96xp1v0r 243 6 ( ( -LRB- cord-262511-96xp1v0r 243 7 TTP TTP NNP cord-262511-96xp1v0r 243 8 ) ) -RRB- cord-262511-96xp1v0r 243 9 identified identify VBN cord-262511-96xp1v0r 243 10 by by IN cord-262511-96xp1v0r 243 11 global global JJ cord-262511-96xp1v0r 243 12 analysis analysis NN cord-262511-96xp1v0r 243 13 of of IN cord-262511-96xp1v0r 243 14 stabilized stabilize VBN cord-262511-96xp1v0r 243 15 transcripts transcript NNS cord-262511-96xp1v0r 243 16 in in IN cord-262511-96xp1v0r 243 17 TTP ttp NN cord-262511-96xp1v0r 243 18 - - HYPH cord-262511-96xp1v0r 243 19 deficient deficient JJ cord-262511-96xp1v0r 243 20 fibroblasts fibroblast NNS cord-262511-96xp1v0r 244 1 Concurrent concurrent JJ cord-262511-96xp1v0r 244 2 versus versus IN cord-262511-96xp1v0r 244 3 individual individual JJ cord-262511-96xp1v0r 244 4 binding binding NN cord-262511-96xp1v0r 244 5 of of IN cord-262511-96xp1v0r 244 6 HuR hur NN cord-262511-96xp1v0r 244 7 and and CC cord-262511-96xp1v0r 244 8 AUF1 AUF1 NNP cord-262511-96xp1v0r 244 9 to to TO cord-262511-96xp1v0r 244 10 common common JJ cord-262511-96xp1v0r 244 11 labile labile JJ cord-262511-96xp1v0r 244 12 target target NN cord-262511-96xp1v0r 244 13 mRNAs mRNAs . cord-262511-96xp1v0r 245 1 The the DT cord-262511-96xp1v0r 245 2 3Ј 3ј CD cord-262511-96xp1v0r 245 3 untranslated untranslated JJ cord-262511-96xp1v0r 245 4 region region NN cord-262511-96xp1v0r 245 5 of of IN cord-262511-96xp1v0r 245 6 tumor tumor NN cord-262511-96xp1v0r 245 7 necrosis necrosis NN cord-262511-96xp1v0r 245 8 factor factor NN cord-262511-96xp1v0r 246 1 ␣ ␣ NNP cord-262511-96xp1v0r 246 2 mRNA mRNA NNP cord-262511-96xp1v0r 246 3 is be VBZ cord-262511-96xp1v0r 246 4 a a DT cord-262511-96xp1v0r 246 5 target target NN cord-262511-96xp1v0r 246 6 of of IN cord-262511-96xp1v0r 246 7 the the DT cord-262511-96xp1v0r 246 8 mRNA mrna NN cord-262511-96xp1v0r 246 9 - - HYPH cord-262511-96xp1v0r 246 10 stabilizing stabilize VBG cord-262511-96xp1v0r 246 11 factor factor NN cord-262511-96xp1v0r 246 12 HuR hur NN cord-262511-96xp1v0r 246 13 Distinct distinct JJ cord-262511-96xp1v0r 246 14 domains domain NNS cord-262511-96xp1v0r 246 15 of of IN cord-262511-96xp1v0r 246 16 AU au JJ cord-262511-96xp1v0r 246 17 - - HYPH cord-262511-96xp1v0r 246 18 rich rich JJ cord-262511-96xp1v0r 246 19 elements element NNS cord-262511-96xp1v0r 246 20 exert exert VBP cord-262511-96xp1v0r 246 21 different different JJ cord-262511-96xp1v0r 246 22 functions function NNS cord-262511-96xp1v0r 246 23 in in IN cord-262511-96xp1v0r 246 24 mRNA mRNA NNP cord-262511-96xp1v0r 246 25 destabilization destabilization NN cord-262511-96xp1v0r 246 26 and and CC cord-262511-96xp1v0r 246 27 stabilization stabilization NN cord-262511-96xp1v0r 246 28 by by IN cord-262511-96xp1v0r 246 29 p38 p38 CD cord-262511-96xp1v0r 246 30 mitogenactivated mitogenactivated JJ cord-262511-96xp1v0r 246 31 protein protein NNP cord-262511-96xp1v0r 246 32 kinase kinase NN cord-262511-96xp1v0r 246 33 or or CC cord-262511-96xp1v0r 246 34 HuR HuR NNP cord-262511-96xp1v0r 246 35 Stabilization Stabilization NNP cord-262511-96xp1v0r 246 36 of of IN cord-262511-96xp1v0r 246 37 urokinase urokinase NNP cord-262511-96xp1v0r 246 38 and and CC cord-262511-96xp1v0r 246 39 urokinase urokinase NNP cord-262511-96xp1v0r 246 40 receptor receptor NN cord-262511-96xp1v0r 247 1 mRNAs mRNAs NNP cord-262511-96xp1v0r 247 2 by by IN cord-262511-96xp1v0r 247 3 HuR HuR NNP cord-262511-96xp1v0r 247 4 is be VBZ cord-262511-96xp1v0r 247 5 linked link VBN cord-262511-96xp1v0r 247 6 to to IN cord-262511-96xp1v0r 247 7 its -PRON- PRP$ cord-262511-96xp1v0r 247 8 cytoplasmic cytoplasmic JJ cord-262511-96xp1v0r 247 9 accumulation accumulation NN cord-262511-96xp1v0r 247 10 induced induce VBN cord-262511-96xp1v0r 247 11 by by IN cord-262511-96xp1v0r 247 12 activated activate VBN cord-262511-96xp1v0r 247 13 mitogen mitogen NNP cord-262511-96xp1v0r 247 14 - - HYPH cord-262511-96xp1v0r 247 15 activated activate VBN cord-262511-96xp1v0r 247 16 protein protein NN cord-262511-96xp1v0r 247 17 kinase kinase NN cord-262511-96xp1v0r 247 18 - - HYPH cord-262511-96xp1v0r 247 19 activated activate VBN cord-262511-96xp1v0r 247 20 protein protein NN cord-262511-96xp1v0r 247 21 kinase kinase NN cord-262511-96xp1v0r 247 22 2 2 CD cord-262511-96xp1v0r 247 23 Tethering Tethering NNP cord-262511-96xp1v0r 247 24 KSRP KSRP NNP cord-262511-96xp1v0r 247 25 , , , cord-262511-96xp1v0r 247 26 a a DT cord-262511-96xp1v0r 247 27 decay decay NN cord-262511-96xp1v0r 247 28 - - HYPH cord-262511-96xp1v0r 247 29 promoting promote VBG cord-262511-96xp1v0r 247 30 AU au JJ cord-262511-96xp1v0r 247 31 - - HYPH cord-262511-96xp1v0r 247 32 rich rich JJ cord-262511-96xp1v0r 247 33 element element NN cord-262511-96xp1v0r 247 34 - - HYPH cord-262511-96xp1v0r 247 35 binding bind VBG cord-262511-96xp1v0r 247 36 protein protein NN cord-262511-96xp1v0r 247 37 , , , cord-262511-96xp1v0r 247 38 to to IN cord-262511-96xp1v0r 247 39 mRNAs mrnas XX cord-262511-96xp1v0r 248 1 elicits elicit VBZ cord-262511-96xp1v0r 248 2 mRNA mRNA NNP cord-262511-96xp1v0r 248 3 decay decay NN cord-262511-96xp1v0r 249 1 The the DT cord-262511-96xp1v0r 249 2 ARE are VBP cord-262511-96xp1v0r 249 3 - - HYPH cord-262511-96xp1v0r 249 4 dependent dependent JJ cord-262511-96xp1v0r 249 5 mRNA mrna NN cord-262511-96xp1v0r 249 6 - - HYPH cord-262511-96xp1v0r 249 7 destabilizing destabilize VBG cord-262511-96xp1v0r 249 8 activity activity NN cord-262511-96xp1v0r 249 9 of of IN cord-262511-96xp1v0r 249 10 BRF1 BRF1 NNP cord-262511-96xp1v0r 249 11 is be VBZ cord-262511-96xp1v0r 249 12 regulated regulate VBN cord-262511-96xp1v0r 249 13 by by IN cord-262511-96xp1v0r 249 14 protein protein NN cord-262511-96xp1v0r 249 15 kinase kinase NN cord-262511-96xp1v0r 249 16 B B NNP cord-262511-96xp1v0r 249 17 RNA rna NN cord-262511-96xp1v0r 249 18 - - HYPH cord-262511-96xp1v0r 249 19 quality quality NN cord-262511-96xp1v0r 249 20 control control NN cord-262511-96xp1v0r 249 21 by by IN cord-262511-96xp1v0r 249 22 the the DT cord-262511-96xp1v0r 249 23 exosome exosome NNP cord-262511-96xp1v0r 249 24 Multiple multiple JJ cord-262511-96xp1v0r 249 25 processing processing NN cord-262511-96xp1v0r 249 26 body body NN cord-262511-96xp1v0r 249 27 factors factor NNS cord-262511-96xp1v0r 249 28 and and CC cord-262511-96xp1v0r 249 29 the the DT cord-262511-96xp1v0r 249 30 ARE are VBP cord-262511-96xp1v0r 250 1 binding bind VBG cord-262511-96xp1v0r 250 2 protein protein NN cord-262511-96xp1v0r 250 3 TTP TTP NNP cord-262511-96xp1v0r 250 4 activate activate VBP cord-262511-96xp1v0r 250 5 mRNA mRNA NNP cord-262511-96xp1v0r 250 6 decapping decappe VBG cord-262511-96xp1v0r 250 7 Recruitment Recruitment NNP cord-262511-96xp1v0r 250 8 and and CC cord-262511-96xp1v0r 250 9 activation activation NN cord-262511-96xp1v0r 250 10 of of IN cord-262511-96xp1v0r 250 11 mRNA mrna NN cord-262511-96xp1v0r 250 12 decay decay NN cord-262511-96xp1v0r 250 13 enzymes enzyme NNS cord-262511-96xp1v0r 250 14 by by IN cord-262511-96xp1v0r 250 15 two two CD cord-262511-96xp1v0r 250 16 ARE are VBP cord-262511-96xp1v0r 250 17 - - HYPH cord-262511-96xp1v0r 250 18 mediated mediate VBN cord-262511-96xp1v0r 250 19 decay decay NN cord-262511-96xp1v0r 250 20 activation activation NN cord-262511-96xp1v0r 250 21 domains domain NNS cord-262511-96xp1v0r 250 22 in in IN cord-262511-96xp1v0r 250 23 the the DT cord-262511-96xp1v0r 250 24 proteins protein NNS cord-262511-96xp1v0r 251 1 TTP TTP NNP cord-262511-96xp1v0r 251 2 and and CC cord-262511-96xp1v0r 251 3 BRF-1 BRF-1 NNP cord-262511-96xp1v0r 252 1 ARE- ARE- NNP cord-262511-96xp1v0r 253 1 mRNA mRNA NNP cord-262511-96xp1v0r 253 2 degradation degradation NN cord-262511-96xp1v0r 253 3 requires require VBZ cord-262511-96xp1v0r 253 4 the the DT cord-262511-96xp1v0r 253 5 5Ј-3Ј 5ј-3ј CD cord-262511-96xp1v0r 253 6 decay decay NN cord-262511-96xp1v0r 253 7 pathway pathway NN cord-262511-96xp1v0r 253 8 MAPKAP MAPKAP NNP cord-262511-96xp1v0r 253 9 kinases kinase NNS cord-262511-96xp1v0r 253 10 - - HYPH cord-262511-96xp1v0r 253 11 MKs MKs NNP cord-262511-96xp1v0r 253 12 - - HYPH cord-262511-96xp1v0r 253 13 two two CD cord-262511-96xp1v0r 253 14 's 's POS cord-262511-96xp1v0r 253 15 company company NN cord-262511-96xp1v0r 253 16 , , , cord-262511-96xp1v0r 253 17 three three CD cord-262511-96xp1v0r 253 18 's 's POS cord-262511-96xp1v0r 253 19 a a DT cord-262511-96xp1v0r 253 20 crowd crowd NN cord-262511-96xp1v0r 254 1 The the DT cord-262511-96xp1v0r 254 2 RNA RNA NNP cord-262511-96xp1v0r 254 3 - - HYPH cord-262511-96xp1v0r 254 4 binding bind VBG cord-262511-96xp1v0r 254 5 protein protein NN cord-262511-96xp1v0r 254 6 KSRP KSRP NNP cord-262511-96xp1v0r 254 7 promotes promote VBZ cord-262511-96xp1v0r 254 8 decay decay NN cord-262511-96xp1v0r 254 9 of of IN cord-262511-96xp1v0r 254 10 ␤ ␤ CD cord-262511-96xp1v0r 255 1 -catenin -catenin : cord-262511-96xp1v0r 255 2 mRNA mRNA NNP cord-262511-96xp1v0r 255 3 and and CC cord-262511-96xp1v0r 255 4 is be VBZ cord-262511-96xp1v0r 255 5 inactivated inactivate VBN cord-262511-96xp1v0r 255 6 by by IN cord-262511-96xp1v0r 255 7 PI3K PI3K NNP cord-262511-96xp1v0r 255 8 - - HYPH cord-262511-96xp1v0r 255 9 AKT AKT NNP cord-262511-96xp1v0r 255 10 signaling signal VBG cord-262511-96xp1v0r 255 11 Mitogen Mitogen NNP cord-262511-96xp1v0r 255 12 - - HYPH cord-262511-96xp1v0r 255 13 activated activate VBN cord-262511-96xp1v0r 255 14 protein protein NN cord-262511-96xp1v0r 255 15 kinase kinase NN cord-262511-96xp1v0r 255 16 - - HYPH cord-262511-96xp1v0r 255 17 dependent dependent JJ cord-262511-96xp1v0r 255 18 and and CC cord-262511-96xp1v0r 255 19 -independent -independent JJ cord-262511-96xp1v0r 255 20 signaling signaling NN cord-262511-96xp1v0r 255 21 of of IN cord-262511-96xp1v0r 255 22 mRNA mrna NN cord-262511-96xp1v0r 255 23 stability stability NN cord-262511-96xp1v0r 255 24 of of IN cord-262511-96xp1v0r 255 25 AU AU NNP cord-262511-96xp1v0r 255 26 - - HYPH cord-262511-96xp1v0r 255 27 rich rich JJ cord-262511-96xp1v0r 255 28 elementcontaining elementcontaining NN cord-262511-96xp1v0r 255 29 transcripts transcript NNS cord-262511-96xp1v0r 256 1 Mitogen Mitogen NNP cord-262511-96xp1v0r 256 2 - - HYPH cord-262511-96xp1v0r 256 3 activated activate VBN cord-262511-96xp1v0r 256 4 protein protein NN cord-262511-96xp1v0r 257 1 kinase kinase NN cord-262511-96xp1v0r 257 2 - - HYPH cord-262511-96xp1v0r 257 3 activated activate VBN cord-262511-96xp1v0r 257 4 protein protein NN cord-262511-96xp1v0r 257 5 kinase kinase NN cord-262511-96xp1v0r 257 6 2 2 CD cord-262511-96xp1v0r 257 7 regulates regulate VBZ cord-262511-96xp1v0r 257 8 tumor tumor NN cord-262511-96xp1v0r 257 9 necrosis necrosis NN cord-262511-96xp1v0r 257 10 factor factor NN cord-262511-96xp1v0r 257 11 mRNA mRNA NNP cord-262511-96xp1v0r 257 12 stability stability NN cord-262511-96xp1v0r 257 13 and and CC cord-262511-96xp1v0r 257 14 translation translation NN cord-262511-96xp1v0r 257 15 mainly mainly RB cord-262511-96xp1v0r 257 16 by by IN cord-262511-96xp1v0r 257 17 altering alter VBG cord-262511-96xp1v0r 257 18 tristetraprolin tristetraprolin NN cord-262511-96xp1v0r 257 19 expression expression NN cord-262511-96xp1v0r 257 20 , , , cord-262511-96xp1v0r 257 21 stability stability NN cord-262511-96xp1v0r 257 22 , , , cord-262511-96xp1v0r 257 23 and and CC cord-262511-96xp1v0r 257 24 binding bind VBG cord-262511-96xp1v0r 257 25 to to IN cord-262511-96xp1v0r 257 26 adenine/ adenine/ CD cord-262511-96xp1v0r 257 27 uridine uridine JJ cord-262511-96xp1v0r 257 28 - - HYPH cord-262511-96xp1v0r 257 29 rich rich JJ cord-262511-96xp1v0r 257 30 element element NN cord-262511-96xp1v0r 258 1 Posttranslational posttranslational JJ cord-262511-96xp1v0r 258 2 regulation regulation NN cord-262511-96xp1v0r 258 3 of of IN cord-262511-96xp1v0r 258 4 tristetraprolin tristetraprolin NNP cord-262511-96xp1v0r 258 5 subcellular subcellular JJ cord-262511-96xp1v0r 258 6 localization localization NN cord-262511-96xp1v0r 258 7 and and CC cord-262511-96xp1v0r 258 8 protein protein NN cord-262511-96xp1v0r 258 9 stability stability NN cord-262511-96xp1v0r 258 10 by by IN cord-262511-96xp1v0r 258 11 p38 p38 CD cord-262511-96xp1v0r 258 12 mitogenactivated mitogenactivated JJ cord-262511-96xp1v0r 258 13 protein protein NNP cord-262511-96xp1v0r 258 14 kinase kinase NN cord-262511-96xp1v0r 258 15 and and CC cord-262511-96xp1v0r 258 16 extracellular extracellular JJ cord-262511-96xp1v0r 258 17 signal signal NN cord-262511-96xp1v0r 258 18 - - HYPH cord-262511-96xp1v0r 258 19 regulated regulate VBN cord-262511-96xp1v0r 258 20 kinase kinase NN cord-262511-96xp1v0r 258 21 pathways pathway NNS cord-262511-96xp1v0r 259 1 The the DT cord-262511-96xp1v0r 259 2 stability stability NN cord-262511-96xp1v0r 259 3 of of IN cord-262511-96xp1v0r 259 4 tristetraprolin tristetraprolin NNP cord-262511-96xp1v0r 259 5 mRNA mRNA NNP cord-262511-96xp1v0r 259 6 is be VBZ cord-262511-96xp1v0r 259 7 regulated regulate VBN cord-262511-96xp1v0r 259 8 by by IN cord-262511-96xp1v0r 259 9 mitogen mitogen NN cord-262511-96xp1v0r 259 10 - - HYPH cord-262511-96xp1v0r 259 11 activated activate VBN cord-262511-96xp1v0r 259 12 protein protein NN cord-262511-96xp1v0r 259 13 kinase kinase NN cord-262511-96xp1v0r 259 14 p38 p38 CD cord-262511-96xp1v0r 259 15 and and CC cord-262511-96xp1v0r 259 16 by by IN cord-262511-96xp1v0r 259 17 tristetraprolin tristetraprolin NNP cord-262511-96xp1v0r 259 18 itself -PRON- PRP cord-262511-96xp1v0r 260 1 The the DT cord-262511-96xp1v0r 260 2 role role NN cord-262511-96xp1v0r 260 3 of of IN cord-262511-96xp1v0r 260 4 mRNA mrna NN cord-262511-96xp1v0r 260 5 turnover turnover NN cord-262511-96xp1v0r 260 6 in in IN cord-262511-96xp1v0r 260 7 the the DT cord-262511-96xp1v0r 260 8 regulation regulation NN cord-262511-96xp1v0r 260 9 of of IN cord-262511-96xp1v0r 260 10 tristetraprolin tristetraprolin NNP cord-262511-96xp1v0r 260 11 expression expression NN cord-262511-96xp1v0r 260 12 : : : cord-262511-96xp1v0r 260 13 evidence evidence NN cord-262511-96xp1v0r 260 14 for for IN cord-262511-96xp1v0r 260 15 an an DT cord-262511-96xp1v0r 260 16 extracellular extracellular JJ cord-262511-96xp1v0r 260 17 signal signal NN cord-262511-96xp1v0r 260 18 - - HYPH cord-262511-96xp1v0r 260 19 regulated regulate VBN cord-262511-96xp1v0r 260 20 kinase kinase NN cord-262511-96xp1v0r 260 21 - - HYPH cord-262511-96xp1v0r 260 22 specific specific JJ cord-262511-96xp1v0r 260 23 , , , cord-262511-96xp1v0r 260 24 AU AU NNP cord-262511-96xp1v0r 260 25 - - HYPH cord-262511-96xp1v0r 260 26 rich rich JJ cord-262511-96xp1v0r 260 27 element element NN cord-262511-96xp1v0r 260 28 - - HYPH cord-262511-96xp1v0r 260 29 dependent dependent JJ cord-262511-96xp1v0r 260 30 , , , cord-262511-96xp1v0r 260 31 autoregulatory autoregulatory NNP cord-262511-96xp1v0r 260 32 pathway pathway NNP cord-262511-96xp1v0r 260 33 Structure Structure NNP cord-262511-96xp1v0r 260 34 / / SYM cord-262511-96xp1v0r 260 35 function function NN cord-262511-96xp1v0r 260 36 analysis analysis NN cord-262511-96xp1v0r 260 37 of of IN cord-262511-96xp1v0r 260 38 tristetraprolin tristetraprolin NNP cord-262511-96xp1v0r 260 39 ( ( -LRB- cord-262511-96xp1v0r 260 40 TTP TTP NNP cord-262511-96xp1v0r 260 41 ) ) -RRB- cord-262511-96xp1v0r 260 42 : : : cord-262511-96xp1v0r 261 1 p38 p38 CD cord-262511-96xp1v0r 261 2 stress stress NN cord-262511-96xp1v0r 261 3 - - HYPH cord-262511-96xp1v0r 261 4 activated activate VBN cord-262511-96xp1v0r 261 5 protein protein NN cord-262511-96xp1v0r 261 6 kinase kinase NN cord-262511-96xp1v0r 261 7 and and CC cord-262511-96xp1v0r 261 8 lipopolysaccharide lipopolysaccharide NN cord-262511-96xp1v0r 261 9 stimulation stimulation NN cord-262511-96xp1v0r 261 10 do do VBP cord-262511-96xp1v0r 261 11 not not RB cord-262511-96xp1v0r 261 12 alter alter VB cord-262511-96xp1v0r 261 13 TTP TTP NNP cord-262511-96xp1v0r 261 14 function function NN cord-262511-96xp1v0r 261 15 MK2-induced mk2-induce VBN cord-262511-96xp1v0r 261 16 tristetraprolin:14 tristetraprolin:14 NNP cord-262511-96xp1v0r 261 17 - - HYPH cord-262511-96xp1v0r 261 18 3 3 CD cord-262511-96xp1v0r 261 19 - - SYM cord-262511-96xp1v0r 261 20 3 3 CD cord-262511-96xp1v0r 261 21 complexes complex NNS cord-262511-96xp1v0r 261 22 prevent prevent VBP cord-262511-96xp1v0r 261 23 stress stress NN cord-262511-96xp1v0r 261 24 granule granule NNP cord-262511-96xp1v0r 261 25 association association NNP cord-262511-96xp1v0r 261 26 and and CC cord-262511-96xp1v0r 261 27 ARE ARE NNP cord-262511-96xp1v0r 261 28 - - HYPH cord-262511-96xp1v0r 261 29 mRNA mrna NN cord-262511-96xp1v0r 261 30 decay decay NN cord-262511-96xp1v0r 262 1 The the DT cord-262511-96xp1v0r 262 2 mitogen mitogen NN cord-262511-96xp1v0r 262 3 - - HYPH cord-262511-96xp1v0r 262 4 activated activate VBN cord-262511-96xp1v0r 262 5 protein protein NN cord-262511-96xp1v0r 262 6 kinase kinase NN cord-262511-96xp1v0r 262 7 ( ( -LRB- cord-262511-96xp1v0r 263 1 MAPK)-activated MAPK)-activated NNP cord-262511-96xp1v0r 263 2 protein protein NN cord-262511-96xp1v0r 263 3 kinases kinase NNS cord-262511-96xp1v0r 263 4 MK2 MK2 NNP cord-262511-96xp1v0r 263 5 and and CC cord-262511-96xp1v0r 263 6 MK3 MK3 NNP cord-262511-96xp1v0r 263 7 cooperate cooperate VBP cord-262511-96xp1v0r 263 8 in in IN cord-262511-96xp1v0r 263 9 stimulation stimulation NN cord-262511-96xp1v0r 263 10 of of IN cord-262511-96xp1v0r 263 11 tumor tumor NN cord-262511-96xp1v0r 263 12 necrosis necrosis NN cord-262511-96xp1v0r 263 13 factor factor NN cord-262511-96xp1v0r 263 14 biosynthesis biosynthesis NN cord-262511-96xp1v0r 263 15 and and CC cord-262511-96xp1v0r 263 16 stabilization stabilization NN cord-262511-96xp1v0r 263 17 of of IN cord-262511-96xp1v0r 263 18 p38 p38 CD cord-262511-96xp1v0r 263 19 MAPK MAPK NNP cord-262511-96xp1v0r 263 20 is be VBZ cord-262511-96xp1v0r 263 21 a a DT cord-262511-96xp1v0r 263 22 p37 p37 NN cord-262511-96xp1v0r 263 23 AUF1-binding auf1-binde VBG cord-262511-96xp1v0r 263 24 protein protein NN cord-262511-96xp1v0r 263 25 that that WDT cord-262511-96xp1v0r 263 26 facilitates facilitate VBZ cord-262511-96xp1v0r 263 27 AUF1 AUF1 NNP cord-262511-96xp1v0r 263 28 transport transport NN cord-262511-96xp1v0r 263 29 and and CC cord-262511-96xp1v0r 263 30 AU AU NNP cord-262511-96xp1v0r 263 31 - - HYPH cord-262511-96xp1v0r 263 32 rich rich JJ cord-262511-96xp1v0r 263 33 mRNA mrna NN cord-262511-96xp1v0r 263 34 decay decay VB cord-262511-96xp1v0r 263 35 Posttranscriptional Posttranscriptional NNP cord-262511-96xp1v0r 263 36 regulation regulation NN cord-262511-96xp1v0r 263 37 of of IN cord-262511-96xp1v0r 263 38 TNF TNF NNP cord-262511-96xp1v0r 263 39 ␣ ␣ NN cord-262511-96xp1v0r 263 40 expression expression NN cord-262511-96xp1v0r 263 41 via via IN cord-262511-96xp1v0r 263 42 eukaryotic eukaryotic JJ cord-262511-96xp1v0r 263 43 initiation initiation NN cord-262511-96xp1v0r 263 44 factor factor NN cord-262511-96xp1v0r 263 45 4E 4E NNP cord-262511-96xp1v0r 263 46 ( ( -LRB- cord-262511-96xp1v0r 263 47 eIF4E eif4e CD cord-262511-96xp1v0r 263 48 ) ) -RRB- cord-262511-96xp1v0r 263 49 phosphorylation phosphorylation NN cord-262511-96xp1v0r 263 50 in in IN cord-262511-96xp1v0r 263 51 mouse mouse NN cord-262511-96xp1v0r 263 52 macrophages macrophage NNS cord-262511-96xp1v0r 264 1 The the DT cord-262511-96xp1v0r 264 2 Mnks Mnks NNPS cord-262511-96xp1v0r 264 3 are be VBP cord-262511-96xp1v0r 264 4 novel novel JJ cord-262511-96xp1v0r 264 5 components component NNS cord-262511-96xp1v0r 264 6 in in IN cord-262511-96xp1v0r 264 7 the the DT cord-262511-96xp1v0r 264 8 control control NN cord-262511-96xp1v0r 264 9 of of IN cord-262511-96xp1v0r 264 10 TNF TNF NNP cord-262511-96xp1v0r 264 11 ␣ ␣ NNP cord-262511-96xp1v0r 264 12 biosynthesis biosynthesis NN cord-262511-96xp1v0r 264 13 and and CC cord-262511-96xp1v0r 264 14 phosphorylate phosphorylate VB cord-262511-96xp1v0r 264 15 and and CC cord-262511-96xp1v0r 264 16 regulate regulate VB cord-262511-96xp1v0r 264 17 hnRNP hnrnp DT cord-262511-96xp1v0r 265 1 A1 A1 NNP cord-262511-96xp1v0r 265 2 Stability stability NN cord-262511-96xp1v0r 265 3 of of IN cord-262511-96xp1v0r 265 4 CXCL-8 CXCL-8 NNPS cord-262511-96xp1v0r 265 5 and and CC cord-262511-96xp1v0r 265 6 related relate VBN cord-262511-96xp1v0r 266 1 AU AU NNP cord-262511-96xp1v0r 266 2 - - HYPH cord-262511-96xp1v0r 266 3 rich rich JJ cord-262511-96xp1v0r 266 4 mRNAs mRNAs NNPS cord-262511-96xp1v0r 266 5 in in IN cord-262511-96xp1v0r 266 6 the the DT cord-262511-96xp1v0r 266 7 context context NN cord-262511-96xp1v0r 266 8 of of IN cord-262511-96xp1v0r 266 9 hepatitis hepatitis NN cord-262511-96xp1v0r 266 10 C C NNP cord-262511-96xp1v0r 266 11 virus virus NN cord-262511-96xp1v0r 266 12 replication replication NN cord-262511-96xp1v0r 266 13 in in IN cord-262511-96xp1v0r 266 14 vitro vitro FW cord-262511-96xp1v0r 267 1 Toll toll NN cord-262511-96xp1v0r 267 2 IL-1 IL-1 NNP cord-262511-96xp1v0r 267 3 receptors receptor NNS cord-262511-96xp1v0r 267 4 differ differ VBP cord-262511-96xp1v0r 267 5 in in IN cord-262511-96xp1v0r 267 6 their -PRON- PRP$ cord-262511-96xp1v0r 267 7 ability ability NN cord-262511-96xp1v0r 267 8 to to TO cord-262511-96xp1v0r 267 9 promote promote VB cord-262511-96xp1v0r 267 10 the the DT cord-262511-96xp1v0r 267 11 stabilization stabilization NN cord-262511-96xp1v0r 267 12 of of IN cord-262511-96xp1v0r 267 13 adenosine adenosine NN cord-262511-96xp1v0r 267 14 and and CC cord-262511-96xp1v0r 267 15 uridine uridine NN cord-262511-96xp1v0r 267 16 - - HYPH cord-262511-96xp1v0r 267 17 rich rich JJ cord-262511-96xp1v0r 267 18 elements element NNS cord-262511-96xp1v0r 267 19 containing contain VBG cord-262511-96xp1v0r 267 20 mRNA mRNA NNP cord-262511-96xp1v0r 268 1 Functionally functionally RB cord-262511-96xp1v0r 268 2 independent independent JJ cord-262511-96xp1v0r 268 3 AU AU NNP cord-262511-96xp1v0r 268 4 - - HYPH cord-262511-96xp1v0r 268 5 rich rich JJ cord-262511-96xp1v0r 268 6 sequence sequence NN cord-262511-96xp1v0r 268 7 motifs motif NNS cord-262511-96xp1v0r 268 8 regulate regulate VBP cord-262511-96xp1v0r 268 9 KC KC NNP cord-262511-96xp1v0r 268 10 ( ( -LRB- cord-262511-96xp1v0r 268 11 CXCL1 CXCL1 NNP cord-262511-96xp1v0r 268 12 ) ) -RRB- cord-262511-96xp1v0r 269 1 mRNA mRNA NNP cord-262511-96xp1v0r 269 2 MyD88-mediated myd88-mediate VBN cord-262511-96xp1v0r 269 3 stabilization stabilization NN cord-262511-96xp1v0r 269 4 of of IN cord-262511-96xp1v0r 269 5 interferon- interferon- NN cord-262511-96xp1v0r 269 6 ␥ ␥ CD cord-262511-96xp1v0r 269 7 -induced -induce VBN cord-262511-96xp1v0r 269 8 cytokine cytokine NN cord-262511-96xp1v0r 269 9 and and CC cord-262511-96xp1v0r 269 10 chemokine chemokine NN cord-262511-96xp1v0r 270 1 mRNA mRNA NNP cord-262511-96xp1v0r 270 2 IL-17A IL-17A NNP cord-262511-96xp1v0r 270 3 acts act VBZ cord-262511-96xp1v0r 270 4 via via IN cord-262511-96xp1v0r 270 5 p38 p38 JJ cord-262511-96xp1v0r 270 6 MAPK MAPK NNP cord-262511-96xp1v0r 270 7 to to TO cord-262511-96xp1v0r 270 8 increase increase VB cord-262511-96xp1v0r 270 9 stability stability NN cord-262511-96xp1v0r 270 10 of of IN cord-262511-96xp1v0r 271 1 TNF- tnf- NN cord-262511-96xp1v0r 271 2 ␣ ␣ NN cord-262511-96xp1v0r 271 3 -induced -induce VBD cord-262511-96xp1v0r 271 4 IL-8 IL-8 NNP cord-262511-96xp1v0r 272 1 mRNA mRNA NNP cord-262511-96xp1v0r 272 2 in in IN cord-262511-96xp1v0r 272 3 human human JJ cord-262511-96xp1v0r 272 4 ASM asm JJ cord-262511-96xp1v0r 272 5 Expression expression NN cord-262511-96xp1v0r 272 6 of of IN cord-262511-96xp1v0r 272 7 COX-2 COX-2 NNP cord-262511-96xp1v0r 272 8 in in IN cord-262511-96xp1v0r 272 9 platelet platelet NN cord-262511-96xp1v0r 272 10 - - HYPH cord-262511-96xp1v0r 272 11 monocyte monocyte NN cord-262511-96xp1v0r 272 12 interactions interaction NNS cord-262511-96xp1v0r 272 13 occurs occur VBZ cord-262511-96xp1v0r 272 14 via via IN cord-262511-96xp1v0r 272 15 combinatorial combinatorial JJ cord-262511-96xp1v0r 272 16 regulation regulation NN cord-262511-96xp1v0r 272 17 involving involve VBG cord-262511-96xp1v0r 272 18 adhesion adhesion NN cord-262511-96xp1v0r 272 19 and and CC cord-262511-96xp1v0r 272 20 cytokine cytokine NN cord-262511-96xp1v0r 272 21 signaling signal VBG cord-262511-96xp1v0r 272 22 ELAV ELAV NNP cord-262511-96xp1v0r 272 23 protein protein NN cord-262511-96xp1v0r 272 24 HuA hua NN cord-262511-96xp1v0r 272 25 ( ( -LRB- cord-262511-96xp1v0r 272 26 HuR HuR NNP cord-262511-96xp1v0r 272 27 ) ) -RRB- cord-262511-96xp1v0r 272 28 can can MD cord-262511-96xp1v0r 272 29 redistribute redistribute VB cord-262511-96xp1v0r 272 30 between between IN cord-262511-96xp1v0r 272 31 nucleus nucleus NN cord-262511-96xp1v0r 272 32 and and CC cord-262511-96xp1v0r 272 33 cytoplasm cytoplasm NN cord-262511-96xp1v0r 272 34 and and CC cord-262511-96xp1v0r 272 35 is be VBZ cord-262511-96xp1v0r 272 36 upregulated upregulate VBN cord-262511-96xp1v0r 272 37 during during IN cord-262511-96xp1v0r 272 38 serum serum NN cord-262511-96xp1v0r 272 39 stimulation stimulation NN cord-262511-96xp1v0r 272 40 and and CC cord-262511-96xp1v0r 272 41 T T NNP cord-262511-96xp1v0r 272 42 cell cell NN cord-262511-96xp1v0r 272 43 activation activation NN cord-262511-96xp1v0r 273 1 The the DT cord-262511-96xp1v0r 273 2 Toll Toll NNP cord-262511-96xp1v0r 273 3 - - HYPH cord-262511-96xp1v0r 273 4 like like JJ cord-262511-96xp1v0r 273 5 receptors receptor NNS cord-262511-96xp1v0r 273 6 : : : cord-262511-96xp1v0r 273 7 analysis analysis NN cord-262511-96xp1v0r 273 8 by by IN cord-262511-96xp1v0r 273 9 forward forward JJ cord-262511-96xp1v0r 273 10 genetic genetic JJ cord-262511-96xp1v0r 273 11 methods method NNS cord-262511-96xp1v0r 274 1 Pathogen pathogen NN cord-262511-96xp1v0r 274 2 recognition recognition NN cord-262511-96xp1v0r 274 3 and and CC cord-262511-96xp1v0r 274 4 innate innate JJ cord-262511-96xp1v0r 274 5 immunity immunity NN cord-262511-96xp1v0r 274 6 MyD88 MyD88 NNS cord-262511-96xp1v0r 274 7 beyond beyond IN cord-262511-96xp1v0r 274 8 Toll toll NN cord-262511-96xp1v0r 275 1 The the DT cord-262511-96xp1v0r 275 2 role role NN cord-262511-96xp1v0r 275 3 of of IN cord-262511-96xp1v0r 275 4 human human JJ cord-262511-96xp1v0r 275 5 antigen antigen NN cord-262511-96xp1v0r 275 6 R r NN cord-262511-96xp1v0r 275 7 , , , cord-262511-96xp1v0r 275 8 an an DT cord-262511-96xp1v0r 275 9 RNA rna NN cord-262511-96xp1v0r 275 10 - - HYPH cord-262511-96xp1v0r 275 11 binding bind VBG cord-262511-96xp1v0r 275 12 protein protein NN cord-262511-96xp1v0r 275 13 , , , cord-262511-96xp1v0r 275 14 in in IN cord-262511-96xp1v0r 275 15 mediating mediate VBG cord-262511-96xp1v0r 275 16 the the DT cord-262511-96xp1v0r 275 17 stabilization stabilization NN cord-262511-96xp1v0r 275 18 of of IN cord-262511-96xp1v0r 275 19 Toll Toll NNP cord-262511-96xp1v0r 275 20 - - HYPH cord-262511-96xp1v0r 275 21 like like JJ cord-262511-96xp1v0r 275 22 receptor receptor NN cord-262511-96xp1v0r 275 23 4 4 CD cord-262511-96xp1v0r 275 24 mRNA mrna NN cord-262511-96xp1v0r 275 25 induced induce VBN cord-262511-96xp1v0r 275 26 by by IN cord-262511-96xp1v0r 275 27 endotoxin endotoxin NN cord-262511-96xp1v0r 275 28 : : : cord-262511-96xp1v0r 275 29 a a DT cord-262511-96xp1v0r 275 30 novel novel NN cord-262511-96xp1v0r 275 31 mechanism mechanism NN cord-262511-96xp1v0r 275 32 involved involve VBN cord-262511-96xp1v0r 275 33 in in IN cord-262511-96xp1v0r 275 34 vascular vascular JJ cord-262511-96xp1v0r 275 35 inflammation inflammation NN cord-262511-96xp1v0r 276 1 Lipopolysaccharide Lipopolysaccharide NNP cord-262511-96xp1v0r 276 2 induces induce VBZ cord-262511-96xp1v0r 276 3 formyl formyl NNP cord-262511-96xp1v0r 276 4 peptide peptide NN cord-262511-96xp1v0r 276 5 receptor receptor NN cord-262511-96xp1v0r 276 6 1 1 CD cord-262511-96xp1v0r 276 7 gene gene NN cord-262511-96xp1v0r 276 8 expression expression NN cord-262511-96xp1v0r 276 9 in in IN cord-262511-96xp1v0r 276 10 macrophages macrophage NNS cord-262511-96xp1v0r 276 11 and and CC cord-262511-96xp1v0r 276 12 neutrophils neutrophil NNS cord-262511-96xp1v0r 276 13 via via IN cord-262511-96xp1v0r 276 14 transcriptional transcriptional JJ cord-262511-96xp1v0r 276 15 and and CC cord-262511-96xp1v0r 276 16 posttranscriptional posttranscriptional JJ cord-262511-96xp1v0r 276 17 mechanisms mechanism NNS cord-262511-96xp1v0r 277 1 Signaling signal VBG cord-262511-96xp1v0r 277 2 in in IN cord-262511-96xp1v0r 277 3 lipopolysaccharide lipopolysaccharide NN cord-262511-96xp1v0r 277 4 - - HYPH cord-262511-96xp1v0r 277 5 induced induce VBN cord-262511-96xp1v0r 277 6 stabilization stabilization NN cord-262511-96xp1v0r 277 7 of of IN cord-262511-96xp1v0r 277 8 formyl formyl NNP cord-262511-96xp1v0r 277 9 peptide peptide NNP cord-262511-96xp1v0r 277 10 receptor receptor NN cord-262511-96xp1v0r 277 11 1 1 CD cord-262511-96xp1v0r 277 12 mRNA mrna NN cord-262511-96xp1v0r 277 13 in in IN cord-262511-96xp1v0r 277 14 mouse mouse NN cord-262511-96xp1v0r 277 15 peritoneal peritoneal NN cord-262511-96xp1v0r 277 16 macrophages macrophage NNS cord-262511-96xp1v0r 278 1 RNA rna NN cord-262511-96xp1v0r 278 2 - - HYPH cord-262511-96xp1v0r 278 3 binding bind VBG cord-262511-96xp1v0r 278 4 protein protein NN cord-262511-96xp1v0r 278 5 HuR hur NN cord-262511-96xp1v0r 278 6 is be VBZ cord-262511-96xp1v0r 278 7 required require VBN cord-262511-96xp1v0r 278 8 for for IN cord-262511-96xp1v0r 278 9 stabilization stabilization NN cord-262511-96xp1v0r 278 10 of of IN cord-262511-96xp1v0r 278 11 SLC11A1 SLC11A1 NNP cord-262511-96xp1v0r 278 12 mRNA mRNA NNP cord-262511-96xp1v0r 278 13 and and CC cord-262511-96xp1v0r 278 14 SLC11A1 SLC11A1 NNP cord-262511-96xp1v0r 278 15 protein protein NN cord-262511-96xp1v0r 278 16 expression expression NN cord-262511-96xp1v0r 278 17 Differential differential JJ cord-262511-96xp1v0r 278 18 regulation regulation NN cord-262511-96xp1v0r 278 19 of of IN cord-262511-96xp1v0r 278 20 ARE are VBP cord-262511-96xp1v0r 278 21 - - HYPH cord-262511-96xp1v0r 278 22 mediated mediate VBN cord-262511-96xp1v0r 278 23 TNF tnf NN cord-262511-96xp1v0r 278 24 ␣ ␣ . cord-262511-96xp1v0r 278 25 and and CC cord-262511-96xp1v0r 278 26 IL-1 IL-1 NNP cord-262511-96xp1v0r 278 27 ␤ ␤ . cord-262511-96xp1v0r 279 1 mRNA mrna NN cord-262511-96xp1v0r 279 2 stability stability NN cord-262511-96xp1v0r 279 3 by by IN cord-262511-96xp1v0r 279 4 lipopolysaccharide lipopolysaccharide NN cord-262511-96xp1v0r 279 5 in in IN cord-262511-96xp1v0r 279 6 RAW264.7 RAW264.7 NNP cord-262511-96xp1v0r 279 7 cells cell NNS cord-262511-96xp1v0r 279 8 Induction Induction NNP cord-262511-96xp1v0r 279 9 of of IN cord-262511-96xp1v0r 279 10 expression expression NN cord-262511-96xp1v0r 279 11 of of IN cord-262511-96xp1v0r 279 12 inducible inducible JJ cord-262511-96xp1v0r 279 13 nitric nitric NN cord-262511-96xp1v0r 279 14 oxide oxide NN cord-262511-96xp1v0r 279 15 synthase synthase NN cord-262511-96xp1v0r 279 16 by by IN cord-262511-96xp1v0r 279 17 Taxol Taxol NNP cord-262511-96xp1v0r 279 18 in in IN cord-262511-96xp1v0r 279 19 murine murine JJ cord-262511-96xp1v0r 279 20 macrophage macrophage NN cord-262511-96xp1v0r 279 21 cells cell NNS cord-262511-96xp1v0r 280 1 VEGF VEGF NNP cord-262511-96xp1v0r 280 2 gene gene NN cord-262511-96xp1v0r 280 3 expression expression NN cord-262511-96xp1v0r 280 4 is be VBZ cord-262511-96xp1v0r 280 5 regulated regulate VBN cord-262511-96xp1v0r 280 6 post post NN cord-262511-96xp1v0r 280 7 - - NN cord-262511-96xp1v0r 280 8 transcriptionally transcriptionally RB cord-262511-96xp1v0r 280 9 in in IN cord-262511-96xp1v0r 280 10 macrophages macrophage NNS cord-262511-96xp1v0r 280 11 The the DT cord-262511-96xp1v0r 280 12 tandem tandem JJ cord-262511-96xp1v0r 280 13 CCCH CCCH NNS cord-262511-96xp1v0r 280 14 zinc zinc VBP cord-262511-96xp1v0r 280 15 finger finger NN cord-262511-96xp1v0r 280 16 protein protein NN cord-262511-96xp1v0r 280 17 tristetraprolin tristetraprolin NNP cord-262511-96xp1v0r 280 18 and and CC cord-262511-96xp1v0r 280 19 its -PRON- PRP$ cord-262511-96xp1v0r 280 20 relevance relevance NN cord-262511-96xp1v0r 280 21 to to IN cord-262511-96xp1v0r 280 22 cytokine cytokine NN cord-262511-96xp1v0r 280 23 mRNA mrna NN cord-262511-96xp1v0r 280 24 turnover turnover NN cord-262511-96xp1v0r 280 25 and and CC cord-262511-96xp1v0r 280 26 arthritis arthritis NN cord-262511-96xp1v0r 280 27 A a DT cord-262511-96xp1v0r 280 28 pathogenetic pathogenetic JJ cord-262511-96xp1v0r 280 29 role role NN cord-262511-96xp1v0r 280 30 for for IN cord-262511-96xp1v0r 280 31 TNF TNF NNP cord-262511-96xp1v0r 280 32 ␣ ␣ NNP cord-262511-96xp1v0r 280 33 in in IN cord-262511-96xp1v0r 280 34 the the DT cord-262511-96xp1v0r 280 35 syndrome syndrome NN cord-262511-96xp1v0r 280 36 of of IN cord-262511-96xp1v0r 280 37 cachexia cachexia NN cord-262511-96xp1v0r 280 38 , , , cord-262511-96xp1v0r 280 39 arthritis arthritis NN cord-262511-96xp1v0r 280 40 , , , cord-262511-96xp1v0r 280 41 and and CC cord-262511-96xp1v0r 280 42 autoimmunity autoimmunity NN cord-262511-96xp1v0r 280 43 resulting result VBG cord-262511-96xp1v0r 280 44 from from IN cord-262511-96xp1v0r 280 45 tristetraprolin tristetraprolin NN cord-262511-96xp1v0r 280 46 Impaired impair VBN cord-262511-96xp1v0r 280 47 on on IN cord-262511-96xp1v0r 280 48 / / SYM cord-262511-96xp1v0r 280 49 off off JJ cord-262511-96xp1v0r 280 50 regulation regulation NN cord-262511-96xp1v0r 280 51 of of IN cord-262511-96xp1v0r 280 52 TNF TNF NNP cord-262511-96xp1v0r 280 53 biosynthesis biosynthesis NN cord-262511-96xp1v0r 280 54 in in IN cord-262511-96xp1v0r 280 55 mice mouse NNS cord-262511-96xp1v0r 280 56 lacking lack VBG cord-262511-96xp1v0r 280 57 TNF TNF NNP cord-262511-96xp1v0r 280 58 AU AU NNP cord-262511-96xp1v0r 280 59 - - HYPH cord-262511-96xp1v0r 280 60 rich rich JJ cord-262511-96xp1v0r 280 61 elements element NNS cord-262511-96xp1v0r 280 62 : : : cord-262511-96xp1v0r 280 63 implications implication NNS cord-262511-96xp1v0r 280 64 for for IN cord-262511-96xp1v0r 280 65 joint joint JJ cord-262511-96xp1v0r 280 66 and and CC cord-262511-96xp1v0r 280 67 gut gut NN cord-262511-96xp1v0r 280 68 - - HYPH cord-262511-96xp1v0r 280 69 associated associate VBN cord-262511-96xp1v0r 280 70 immunopathologies immunopathology NNS cord-262511-96xp1v0r 281 1 Endotoxic endotoxic JJ cord-262511-96xp1v0r 281 2 shock shock NN cord-262511-96xp1v0r 281 3 in in IN cord-262511-96xp1v0r 281 4 AUF1 AUF1 NNP cord-262511-96xp1v0r 281 5 knockout knockout NN cord-262511-96xp1v0r 281 6 mice mouse NNS cord-262511-96xp1v0r 281 7 mediated mediate VBN cord-262511-96xp1v0r 281 8 by by IN cord-262511-96xp1v0r 281 9 failure failure NN cord-262511-96xp1v0r 281 10 to to TO cord-262511-96xp1v0r 281 11 degrade degrade VB cord-262511-96xp1v0r 281 12 proinflammatory proinflammatory JJ cord-262511-96xp1v0r 281 13 cytokine cytokine NN cord-262511-96xp1v0r 281 14 mRNAs mrnas CD cord-262511-96xp1v0r 281 15 HuR hur NN cord-262511-96xp1v0r 281 16 as as IN cord-262511-96xp1v0r 281 17 a a DT cord-262511-96xp1v0r 281 18 negative negative JJ cord-262511-96xp1v0r 281 19 posttranscriptional posttranscriptional JJ cord-262511-96xp1v0r 281 20 modulator modulator NN cord-262511-96xp1v0r 281 21 in in IN cord-262511-96xp1v0r 281 22 inflammation inflammation NN cord-262511-96xp1v0r 282 1 Neutrophil Neutrophil NNP cord-262511-96xp1v0r 282 2 signaling signal VBG cord-262511-96xp1v0r 282 3 pathways pathway NNS cord-262511-96xp1v0r 282 4 activated activate VBN cord-262511-96xp1v0r 282 5 by by IN cord-262511-96xp1v0r 282 6 bacterial bacterial JJ cord-262511-96xp1v0r 282 7 DNA dna NN cord-262511-96xp1v0r 282 8 stimulation stimulation NN cord-262511-96xp1v0r 283 1 CpG CpG NNP cord-262511-96xp1v0r 283 2 DNA DNA NNP cord-262511-96xp1v0r 283 3 modulates modulate VBZ cord-262511-96xp1v0r 283 4 interleukin interleukin NN cord-262511-96xp1v0r 283 5 1 1 CD cord-262511-96xp1v0r 283 6 ␤ ␤ . cord-262511-96xp1v0r 284 1 -induced -induce VBN cord-262511-96xp1v0r 284 2 interleukin-8 interleukin-8 JJ cord-262511-96xp1v0r 284 3 expression expression NN cord-262511-96xp1v0r 284 4 in in IN cord-262511-96xp1v0r 284 5 human human JJ cord-262511-96xp1v0r 284 6 bronchial bronchial JJ cord-262511-96xp1v0r 284 7 epithelial epithelial NN cord-262511-96xp1v0r 284 8 ( ( -LRB- cord-262511-96xp1v0r 285 1 16HBE14o- 16hbe14o- LS cord-262511-96xp1v0r 285 2 ) ) -RRB- cord-262511-96xp1v0r 285 3 cells cell NNS cord-262511-96xp1v0r 285 4 Enhancement enhancement NN cord-262511-96xp1v0r 285 5 of of IN cord-262511-96xp1v0r 285 6 dendritic dendritic JJ cord-262511-96xp1v0r 285 7 cell cell NN cord-262511-96xp1v0r 285 8 antigen antigen NN cord-262511-96xp1v0r 285 9 cross cross JJ cord-262511-96xp1v0r 285 10 - - NN cord-262511-96xp1v0r 285 11 presentation presentation NN cord-262511-96xp1v0r 285 12 by by IN cord-262511-96xp1v0r 285 13 CpG CpG NNP cord-262511-96xp1v0r 285 14 DNA DNA NNP cord-262511-96xp1v0r 285 15 involves involve VBZ cord-262511-96xp1v0r 285 16 type type NN cord-262511-96xp1v0r 286 1 I -PRON- PRP cord-262511-96xp1v0r 286 2 IFN IFN NNP cord-262511-96xp1v0r 286 3 and and CC cord-262511-96xp1v0r 286 4 stabilization stabilization NN cord-262511-96xp1v0r 286 5 of of IN cord-262511-96xp1v0r 286 6 class class NN cord-262511-96xp1v0r 287 1 I -PRON- PRP cord-262511-96xp1v0r 288 1 MHC MHC NNP cord-262511-96xp1v0r 288 2 mRNA mRNA NNP cord-262511-96xp1v0r 288 3 Expression expression NN cord-262511-96xp1v0r 288 4 of of IN cord-262511-96xp1v0r 288 5 CD83 CD83 NNP cord-262511-96xp1v0r 288 6 is be VBZ cord-262511-96xp1v0r 288 7 regulated regulate VBN cord-262511-96xp1v0r 288 8 by by IN cord-262511-96xp1v0r 288 9 HuR hur NN cord-262511-96xp1v0r 288 10 via via IN cord-262511-96xp1v0r 288 11 a a DT cord-262511-96xp1v0r 288 12 novel novel JJ cord-262511-96xp1v0r 288 13 cis cis JJ cord-262511-96xp1v0r 288 14 - - HYPH cord-262511-96xp1v0r 288 15 active active JJ cord-262511-96xp1v0r 288 16 coding code VBG cord-262511-96xp1v0r 288 17 region region NN cord-262511-96xp1v0r 288 18 RNA RNA NNP cord-262511-96xp1v0r 288 19 element element NN cord-262511-96xp1v0r 288 20 Anti Anti NNP cord-262511-96xp1v0r 288 21 - - NN cord-262511-96xp1v0r 288 22 immunology immunology NN cord-262511-96xp1v0r 288 23 : : : cord-262511-96xp1v0r 288 24 evasion evasion NN cord-262511-96xp1v0r 288 25 of of IN cord-262511-96xp1v0r 288 26 the the DT cord-262511-96xp1v0r 288 27 host host NN cord-262511-96xp1v0r 288 28 immune immune JJ cord-262511-96xp1v0r 288 29 system system NN cord-262511-96xp1v0r 288 30 by by IN cord-262511-96xp1v0r 288 31 bacterial bacterial JJ cord-262511-96xp1v0r 288 32 and and CC cord-262511-96xp1v0r 288 33 viral viral JJ cord-262511-96xp1v0r 288 34 pathogens pathogen NNS cord-262511-96xp1v0r 289 1 Herpes Herpes NNP cord-262511-96xp1v0r 289 2 simplex simplex NN cord-262511-96xp1v0r 289 3 virus virus NN cord-262511-96xp1v0r 289 4 infection infection NN cord-262511-96xp1v0r 289 5 stabilizes stabilize VBZ cord-262511-96xp1v0r 289 6 cellular cellular JJ cord-262511-96xp1v0r 289 7 IEX-1 IEX-1 NNP cord-262511-96xp1v0r 289 8 mRNA mRNA NNP cord-262511-96xp1v0r 289 9 Herpes Herpes NNP cord-262511-96xp1v0r 289 10 simplex simplex NN cord-262511-96xp1v0r 289 11 virus virus NN cord-262511-96xp1v0r 290 1 ICP27 ICP27 NNP cord-262511-96xp1v0r 290 2 is be VBZ cord-262511-96xp1v0r 290 3 required require VBN cord-262511-96xp1v0r 290 4 for for IN cord-262511-96xp1v0r 290 5 virus virus NN cord-262511-96xp1v0r 290 6 - - HYPH cord-262511-96xp1v0r 290 7 induced induce VBN cord-262511-96xp1v0r 290 8 stabilization stabilization NN cord-262511-96xp1v0r 290 9 of of IN cord-262511-96xp1v0r 290 10 the the DT cord-262511-96xp1v0r 290 11 ARE are NN cord-262511-96xp1v0r 290 12 - - : cord-262511-96xp1v0r 290 13 containing contain VBG cord-262511-96xp1v0r 290 14 IEX-1 IEX-1 NNP cord-262511-96xp1v0r 290 15 mRNA mrna NN cord-262511-96xp1v0r 290 16 encoded encode VBN cord-262511-96xp1v0r 290 17 by by IN cord-262511-96xp1v0r 290 18 the the DT cord-262511-96xp1v0r 290 19 human human JJ cord-262511-96xp1v0r 290 20 IER3 IER3 NNP cord-262511-96xp1v0r 290 21 gene gene NN cord-262511-96xp1v0r 291 1 The the DT cord-262511-96xp1v0r 291 2 Epstein Epstein NNP cord-262511-96xp1v0r 291 3 - - HYPH cord-262511-96xp1v0r 291 4 Barr Barr NNP cord-262511-96xp1v0r 291 5 virus virus NN cord-262511-96xp1v0r 291 6 oncoprotein oncoprotein NNP cord-262511-96xp1v0r 291 7 latent latent NNP cord-262511-96xp1v0r 291 8 membrane membrane NN cord-262511-96xp1v0r 291 9 protein protein NN cord-262511-96xp1v0r 291 10 1 1 CD cord-262511-96xp1v0r 291 11 induces induce VBZ cord-262511-96xp1v0r 291 12 expression expression NN cord-262511-96xp1v0r 291 13 of of IN cord-262511-96xp1v0r 291 14 the the DT cord-262511-96xp1v0r 291 15 chemokine chemokine NN cord-262511-96xp1v0r 291 16 IP-10 IP-10 NNP cord-262511-96xp1v0r 291 17 : : : cord-262511-96xp1v0r 291 18 importance importance NN cord-262511-96xp1v0r 291 19 of of IN cord-262511-96xp1v0r 291 20 mRNA mRNA NNP cord-262511-96xp1v0r 291 21 half half JJ cord-262511-96xp1v0r 291 22 - - HYPH cord-262511-96xp1v0r 291 23 life life NN cord-262511-96xp1v0r 291 24 regulation regulation NN cord-262511-96xp1v0r 292 1 The the DT cord-262511-96xp1v0r 292 2 kaposin kaposin NN cord-262511-96xp1v0r 292 3 B B NNP cord-262511-96xp1v0r 292 4 protein protein NN cord-262511-96xp1v0r 292 5 of of IN cord-262511-96xp1v0r 292 6 KSHV KSHV NNP cord-262511-96xp1v0r 292 7 activates activate VBZ cord-262511-96xp1v0r 292 8 the the DT cord-262511-96xp1v0r 292 9 p38 p38 NNP cord-262511-96xp1v0r 292 10 / / SYM cord-262511-96xp1v0r 292 11 MK2 MK2 NNP cord-262511-96xp1v0r 292 12 pathway pathway NNP cord-262511-96xp1v0r 292 13 and and CC cord-262511-96xp1v0r 292 14 stabilizes stabilize VBZ cord-262511-96xp1v0r 292 15 cytokine cytokine NN cord-262511-96xp1v0r 292 16 mRNAs mrna VBD cord-262511-96xp1v0r 292 17 Phosphorylation Phosphorylation NNP cord-262511-96xp1v0r 292 18 and and CC cord-262511-96xp1v0r 292 19 function function NN cord-262511-96xp1v0r 292 20 of of IN cord-262511-96xp1v0r 292 21 the the DT cord-262511-96xp1v0r 292 22 kaposin kaposin NNP cord-262511-96xp1v0r 292 23 B B NNP cord-262511-96xp1v0r 292 24 direct direct JJ cord-262511-96xp1v0r 292 25 repeats repeat NNS cord-262511-96xp1v0r 292 26 of of IN cord-262511-96xp1v0r 292 27 Kaposi Kaposi NNP cord-262511-96xp1v0r 292 28 's 's POS cord-262511-96xp1v0r 292 29 sarcoma sarcoma NN cord-262511-96xp1v0r 292 30 - - HYPH cord-262511-96xp1v0r 292 31 associated associate VBN cord-262511-96xp1v0r 292 32 herpesvirus herpesvirus NN cord-262511-96xp1v0r 292 33 Kaposi Kaposi NNP cord-262511-96xp1v0r 292 34 's 's POS cord-262511-96xp1v0r 292 35 sarcoma sarcoma NN cord-262511-96xp1v0r 292 36 - - HYPH cord-262511-96xp1v0r 292 37 associated associate VBN cord-262511-96xp1v0r 292 38 herpesvirus herpesvirus NN cord-262511-96xp1v0r 292 39 immune immune JJ cord-262511-96xp1v0r 292 40 modulation modulation NN cord-262511-96xp1v0r 292 41 : : : cord-262511-96xp1v0r 292 42 an an DT cord-262511-96xp1v0r 292 43 overview overview NN cord-262511-96xp1v0r 292 44 Differential differential NN cord-262511-96xp1v0r 292 45 roles role NNS cord-262511-96xp1v0r 292 46 of of IN cord-262511-96xp1v0r 292 47 MDA5 MDA5 NNP cord-262511-96xp1v0r 292 48 and and CC cord-262511-96xp1v0r 292 49 RIG rig NN cord-262511-96xp1v0r 293 1 -I -i DT cord-262511-96xp1v0r 293 2 helicases helicase NNS cord-262511-96xp1v0r 293 3 in in IN cord-262511-96xp1v0r 293 4 the the DT cord-262511-96xp1v0r 293 5 recognition recognition NN cord-262511-96xp1v0r 293 6 of of IN cord-262511-96xp1v0r 293 7 RNA RNA NNP cord-262511-96xp1v0r 293 8 viruses virus NNS cord-262511-96xp1v0r 294 1 5Ј-Triphosphate 5ј-triphosphate CD cord-262511-96xp1v0r 294 2 RNA RNA NNP cord-262511-96xp1v0r 294 3 is be VBZ cord-262511-96xp1v0r 294 4 the the DT cord-262511-96xp1v0r 294 5 ligand ligand NN cord-262511-96xp1v0r 294 6 for for IN cord-262511-96xp1v0r 294 7 RIG rig NN cord-262511-96xp1v0r 294 8 - - : cord-262511-96xp1v0r 294 9 I I NNP cord-262511-96xp1v0r 294 10 RIG rig NN cord-262511-96xp1v0r 294 11 - - : cord-262511-96xp1v0r 294 12 I i NN cord-262511-96xp1v0r 294 13 - - HYPH cord-262511-96xp1v0r 294 14 mediated mediate VBN cord-262511-96xp1v0r 294 15 antiviral antiviral JJ cord-262511-96xp1v0r 294 16 responses response NNS cord-262511-96xp1v0r 294 17 to to IN cord-262511-96xp1v0r 294 18 single single RB cord-262511-96xp1v0r 294 19 - - HYPH cord-262511-96xp1v0r 294 20 stranded strand VBN cord-262511-96xp1v0r 294 21 RNA RNA NNP cord-262511-96xp1v0r 294 22 bearing bear VBG cord-262511-96xp1v0r 294 23 5Ј-phosphates 5ј-phosphates CD cord-262511-96xp1v0r 294 24 Regulation regulation NN cord-262511-96xp1v0r 294 25 of of IN cord-262511-96xp1v0r 294 26 CXCL-8 CXCL-8 NNPS cord-262511-96xp1v0r 294 27 ( ( -LRB- cord-262511-96xp1v0r 294 28 interleukin-8 interleukin-8 NNP cord-262511-96xp1v0r 294 29 ) ) -RRB- cord-262511-96xp1v0r 294 30 induction induction NN cord-262511-96xp1v0r 294 31 by by IN cord-262511-96xp1v0r 294 32 double double RB cord-262511-96xp1v0r 294 33 - - HYPH cord-262511-96xp1v0r 294 34 stranded strand VBN cord-262511-96xp1v0r 294 35 RNA RNA NNP cord-262511-96xp1v0r 294 36 signaling signal VBG cord-262511-96xp1v0r 294 37 pathways pathway NNS cord-262511-96xp1v0r 294 38 during during IN cord-262511-96xp1v0r 294 39 hepatitis hepatitis NN cord-262511-96xp1v0r 294 40 C C NNP cord-262511-96xp1v0r 294 41 virus virus NN cord-262511-96xp1v0r 294 42 infection infection NN cord-262511-96xp1v0r 294 43 Elevated elevated JJ cord-262511-96xp1v0r 294 44 levels level NNS cord-262511-96xp1v0r 294 45 of of IN cord-262511-96xp1v0r 294 46 interleukin-8 interleukin-8 NNP cord-262511-96xp1v0r 294 47 in in IN cord-262511-96xp1v0r 294 48 serum serum NN cord-262511-96xp1v0r 294 49 are be VBP cord-262511-96xp1v0r 294 50 associated associate VBN cord-262511-96xp1v0r 294 51 with with IN cord-262511-96xp1v0r 294 52 hepatitis hepatitis NN cord-262511-96xp1v0r 294 53 C C NNP cord-262511-96xp1v0r 294 54 virus virus NN cord-262511-96xp1v0r 294 55 infection infection NN cord-262511-96xp1v0r 294 56 and and CC cord-262511-96xp1v0r 294 57 resistance resistance NN cord-262511-96xp1v0r 294 58 to to IN cord-262511-96xp1v0r 294 59 interferon interferon NN cord-262511-96xp1v0r 294 60 therapy therapy NN cord-262511-96xp1v0r 294 61 Severe severe JJ cord-262511-96xp1v0r 294 62 acute acute JJ cord-262511-96xp1v0r 294 63 respiratory respiratory JJ cord-262511-96xp1v0r 294 64 syndrome syndrome NN cord-262511-96xp1v0r 294 65 coronavirus coronavirus NN cord-262511-96xp1v0r 295 1 nsp1 nsp1 NNS cord-262511-96xp1v0r 295 2 protein protein NN cord-262511-96xp1v0r 295 3 suppresses suppress VBZ cord-262511-96xp1v0r 295 4 host host NN cord-262511-96xp1v0r 295 5 gene gene NN cord-262511-96xp1v0r 295 6 expression expression NN cord-262511-96xp1v0r 295 7 by by IN cord-262511-96xp1v0r 295 8 promoting promote VBG cord-262511-96xp1v0r 295 9 host host NN cord-262511-96xp1v0r 295 10 mRNA mrna NN cord-262511-96xp1v0r 295 11 degradation degradation NN cord-262511-96xp1v0r 295 12 Posttranscriptional Posttranscriptional NNP cord-262511-96xp1v0r 295 13 suppression suppression NN cord-262511-96xp1v0r 295 14 of of IN cord-262511-96xp1v0r 295 15 interleukin-6 interleukin-6 NNP cord-262511-96xp1v0r 295 16 production production NN cord-262511-96xp1v0r 295 17 by by IN cord-262511-96xp1v0r 295 18 human human JJ cord-262511-96xp1v0r 295 19 cytomegalovirus cytomegalovirus NN cord-262511-96xp1v0r 295 20 The the DT cord-262511-96xp1v0r 295 21 role role NN cord-262511-96xp1v0r 295 22 of of IN cord-262511-96xp1v0r 295 23 post post JJ cord-262511-96xp1v0r 295 24 - - JJ cord-262511-96xp1v0r 295 25 transcriptional transcriptional JJ cord-262511-96xp1v0r 295 26 regulation regulation NN cord-262511-96xp1v0r 295 27 in in IN cord-262511-96xp1v0r 295 28 chemokine chemokine NN cord-262511-96xp1v0r 295 29 gene gene NN cord-262511-96xp1v0r 295 30 expression expression NN cord-262511-96xp1v0r 295 31 in in IN cord-262511-96xp1v0r 295 32 inflammation inflammation NN cord-262511-96xp1v0r 295 33 and and CC cord-262511-96xp1v0r 295 34 allergy allergy NN cord-262511-96xp1v0r 296 1 The the DT cord-262511-96xp1v0r 296 2 U(L)41 u(l)41 JJ cord-262511-96xp1v0r 296 3 protein protein NN cord-262511-96xp1v0r 296 4 of of IN cord-262511-96xp1v0r 296 5 herpes herpes NNP cord-262511-96xp1v0r 296 6 simplex simplex NNP cord-262511-96xp1v0r 296 7 virus virus NN cord-262511-96xp1v0r 296 8 1 1 CD cord-262511-96xp1v0r 296 9 degrades degrade VBZ cord-262511-96xp1v0r 296 10 RNA RNA NNP cord-262511-96xp1v0r 296 11 by by IN cord-262511-96xp1v0r 296 12 endonucleolytic endonucleolytic JJ cord-262511-96xp1v0r 296 13 cleavage cleavage NN cord-262511-96xp1v0r 296 14 in in IN cord-262511-96xp1v0r 296 15 absence absence NN cord-262511-96xp1v0r 296 16 of of IN cord-262511-96xp1v0r 296 17 other other JJ cord-262511-96xp1v0r 296 18 cellular cellular JJ cord-262511-96xp1v0r 296 19 or or CC cord-262511-96xp1v0r 296 20 viral viral JJ cord-262511-96xp1v0r 296 21 proteins protein NNS cord-262511-96xp1v0r 296 22 AU AU NNP cord-262511-96xp1v0r 296 23 - - HYPH cord-262511-96xp1v0r 296 24 rich rich JJ cord-262511-96xp1v0r 296 25 transient transient JJ cord-262511-96xp1v0r 296 26 response response NN cord-262511-96xp1v0r 296 27 transcripts transcript NNS cord-262511-96xp1v0r 296 28 in in IN cord-262511-96xp1v0r 296 29 the the DT cord-262511-96xp1v0r 296 30 human human JJ cord-262511-96xp1v0r 296 31 genome genome NN cord-262511-96xp1v0r 296 32 : : : cord-262511-96xp1v0r 297 1 expressed express VBN cord-262511-96xp1v0r 297 2 sequence sequence NN cord-262511-96xp1v0r 297 3 tag tag NN cord-262511-96xp1v0r 297 4 clustering clustering NN cord-262511-96xp1v0r 297 5 and and CC cord-262511-96xp1v0r 297 6 gene gene NN cord-262511-96xp1v0r 297 7 discovery discovery NN cord-262511-96xp1v0r 297 8 approach approach NN cord-262511-96xp1v0r 298 1 Tristetraprolin Tristetraprolin NNP cord-262511-96xp1v0r 298 2 inhibits inhibit VBZ cord-262511-96xp1v0r 298 3 HIV-1 HIV-1 NNP cord-262511-96xp1v0r 298 4 production production NN cord-262511-96xp1v0r 298 5 by by IN cord-262511-96xp1v0r 298 6 binding bind VBG cord-262511-96xp1v0r 298 7 to to IN cord-262511-96xp1v0r 298 8 genomic genomic JJ cord-262511-96xp1v0r 298 9 RNA RNA NNP cord-262511-96xp1v0r 298 10 Adaptors Adaptors NNP cord-262511-96xp1v0r 298 11 as as IN cord-262511-96xp1v0r 298 12 central central JJ cord-262511-96xp1v0r 298 13 mediators mediator NNS cord-262511-96xp1v0r 298 14 of of IN cord-262511-96xp1v0r 298 15 signal signal NN cord-262511-96xp1v0r 298 16 transduction transduction NN cord-262511-96xp1v0r 298 17 in in IN cord-262511-96xp1v0r 298 18 immune immune JJ cord-262511-96xp1v0r 298 19 cells cell NNS cord-262511-96xp1v0r 298 20 Patterns pattern NNS cord-262511-96xp1v0r 298 21 of of IN cord-262511-96xp1v0r 298 22 coordinate coordinate VBP cord-262511-96xp1v0r 298 23 down down JJ cord-262511-96xp1v0r 298 24 - - HYPH cord-262511-96xp1v0r 298 25 regulation regulation NN cord-262511-96xp1v0r 298 26 of of IN cord-262511-96xp1v0r 298 27 ARE are VBP cord-262511-96xp1v0r 298 28 - - HYPH cord-262511-96xp1v0r 298 29 containing contain VBG cord-262511-96xp1v0r 298 30 transcripts transcript NNS cord-262511-96xp1v0r 298 31 following follow VBG cord-262511-96xp1v0r 298 32 immune immune JJ cord-262511-96xp1v0r 298 33 cell cell NN cord-262511-96xp1v0r 298 34 activation activation NN cord-262511-96xp1v0r 298 35 Stability stability NN cord-262511-96xp1v0r 298 36 regulation regulation NN cord-262511-96xp1v0r 298 37 of of IN cord-262511-96xp1v0r 298 38 mRNA mrna NN cord-262511-96xp1v0r 298 39 and and CC cord-262511-96xp1v0r 298 40 the the DT cord-262511-96xp1v0r 298 41 control control NN cord-262511-96xp1v0r 298 42 of of IN cord-262511-96xp1v0r 298 43 gene gene NN cord-262511-96xp1v0r 298 44 expression expression NN cord-262511-96xp1v0r 298 45 Regulation regulation NN cord-262511-96xp1v0r 298 46 of of IN cord-262511-96xp1v0r 298 47 lymphokine lymphokine NN cord-262511-96xp1v0r 298 48 messenger messenger NN cord-262511-96xp1v0r 298 49 RNA RNA NNP cord-262511-96xp1v0r 298 50 stability stability NN cord-262511-96xp1v0r 298 51 by by IN cord-262511-96xp1v0r 298 52 a a DT cord-262511-96xp1v0r 298 53 surfacemediated surfacemediate VBN cord-262511-96xp1v0r 298 54 T T NNP cord-262511-96xp1v0r 298 55 cell cell NN cord-262511-96xp1v0r 298 56 activation activation NN cord-262511-96xp1v0r 298 57 pathway pathway NN cord-262511-96xp1v0r 298 58 Regulation regulation NN cord-262511-96xp1v0r 298 59 of of IN cord-262511-96xp1v0r 298 60 interleukin-2 interleukin-2 JJ cord-262511-96xp1v0r 298 61 gene gene NN cord-262511-96xp1v0r 298 62 enhancer enhancer NN cord-262511-96xp1v0r 298 63 activity activity NN cord-262511-96xp1v0r 298 64 by by IN cord-262511-96xp1v0r 298 65 the the DT cord-262511-96xp1v0r 298 66 T T NNP cord-262511-96xp1v0r 298 67 cell cell NN cord-262511-96xp1v0r 298 68 accessory accessory NN cord-262511-96xp1v0r 298 69 molecule molecule NN cord-262511-96xp1v0r 298 70 CD28 CD28 NNP cord-262511-96xp1v0r 298 71 Engagement Engagement NNP cord-262511-96xp1v0r 298 72 of of IN cord-262511-96xp1v0r 298 73 CD28 CD28 NNP cord-262511-96xp1v0r 298 74 outside outside RB cord-262511-96xp1v0r 298 75 of of IN cord-262511-96xp1v0r 298 76 the the DT cord-262511-96xp1v0r 298 77 immunological immunological JJ cord-262511-96xp1v0r 298 78 synapse synapse NN cord-262511-96xp1v0r 298 79 results result NNS cord-262511-96xp1v0r 298 80 in in IN cord-262511-96xp1v0r 298 81 up up IN cord-262511-96xp1v0r 298 82 - - HYPH cord-262511-96xp1v0r 298 83 regulation regulation NN cord-262511-96xp1v0r 298 84 of of IN cord-262511-96xp1v0r 298 85 IL-2 IL-2 NNP cord-262511-96xp1v0r 298 86 mRNA mRNA NNP cord-262511-96xp1v0r 298 87 stability stability NN cord-262511-96xp1v0r 298 88 but but CC cord-262511-96xp1v0r 298 89 not not RB cord-262511-96xp1v0r 298 90 IL-2 il-2 NN cord-262511-96xp1v0r 298 91 transcription transcription NN cord-262511-96xp1v0r 298 92 Cutting cutting NN cord-262511-96xp1v0r 298 93 edge edge NN cord-262511-96xp1v0r 298 94 : : : cord-262511-96xp1v0r 299 1 CD28-mediated cd28-mediate VBN cord-262511-96xp1v0r 299 2 transcriptional transcriptional JJ cord-262511-96xp1v0r 299 3 and and CC cord-262511-96xp1v0r 299 4 posttranscriptional posttranscriptional JJ cord-262511-96xp1v0r 299 5 regulation regulation NN cord-262511-96xp1v0r 299 6 of of IN cord-262511-96xp1v0r 299 7 IL-2 IL-2 NNP cord-262511-96xp1v0r 299 8 expression expression NN cord-262511-96xp1v0r 299 9 are be VBP cord-262511-96xp1v0r 299 10 controlled control VBN cord-262511-96xp1v0r 299 11 through through IN cord-262511-96xp1v0r 299 12 different different JJ cord-262511-96xp1v0r 299 13 signaling signal VBG cord-262511-96xp1v0r 299 14 pathways pathway NNS cord-262511-96xp1v0r 300 1 Tristetraprolin Tristetraprolin NNP cord-262511-96xp1v0r 300 2 down down RB cord-262511-96xp1v0r 300 3 - - HYPH cord-262511-96xp1v0r 300 4 regulates regulate VBZ cord-262511-96xp1v0r 300 5 IL-2 IL-2 NNP cord-262511-96xp1v0r 300 6 gene gene NN cord-262511-96xp1v0r 300 7 expression expression NN cord-262511-96xp1v0r 300 8 through through IN cord-262511-96xp1v0r 300 9 AU au JJ cord-262511-96xp1v0r 300 10 - - HYPH cord-262511-96xp1v0r 300 11 rich rich JJ cord-262511-96xp1v0r 300 12 element element NN cord-262511-96xp1v0r 300 13 - - HYPH cord-262511-96xp1v0r 300 14 mediated mediate VBN cord-262511-96xp1v0r 300 15 mRNA mrna NN cord-262511-96xp1v0r 300 16 decay decay NN cord-262511-96xp1v0r 300 17 Integrin Integrin NNP cord-262511-96xp1v0r 300 18 activation activation NN cord-262511-96xp1v0r 300 19 under under IN cord-262511-96xp1v0r 300 20 flow flow NN cord-262511-96xp1v0r 300 21 : : : cord-262511-96xp1v0r 300 22 a a DT cord-262511-96xp1v0r 300 23 local local JJ cord-262511-96xp1v0r 300 24 affair affair NN cord-262511-96xp1v0r 300 25 LFA-1-dependent LFA-1-dependent NNP cord-262511-96xp1v0r 300 26 HuR HuR NNP cord-262511-96xp1v0r 300 27 nuclear nuclear JJ cord-262511-96xp1v0r 300 28 export export NN cord-262511-96xp1v0r 300 29 and and CC cord-262511-96xp1v0r 300 30 cytokine cytokine NN cord-262511-96xp1v0r 301 1 mRNA mRNA NNP cord-262511-96xp1v0r 301 2 stabilization stabilization NN cord-262511-96xp1v0r 301 3 in in IN cord-262511-96xp1v0r 301 4 T T NNP cord-262511-96xp1v0r 301 5 cell cell NN cord-262511-96xp1v0r 301 6 activation activation NN cord-262511-96xp1v0r 301 7 Selective selective JJ cord-262511-96xp1v0r 301 8 cytoplasmic cytoplasmic JJ cord-262511-96xp1v0r 301 9 translocation translocation NN cord-262511-96xp1v0r 301 10 of of IN cord-262511-96xp1v0r 301 11 HuR hur NN cord-262511-96xp1v0r 301 12 and and CC cord-262511-96xp1v0r 301 13 site site NN cord-262511-96xp1v0r 301 14 - - HYPH cord-262511-96xp1v0r 301 15 specific specific JJ cord-262511-96xp1v0r 301 16 binding binding NN cord-262511-96xp1v0r 301 17 to to IN cord-262511-96xp1v0r 301 18 the the DT cord-262511-96xp1v0r 301 19 interleukin-2 interleukin-2 NNP cord-262511-96xp1v0r 301 20 mRNA mrna NN cord-262511-96xp1v0r 301 21 are be VBP cord-262511-96xp1v0r 301 22 not not RB cord-262511-96xp1v0r 301 23 sufficient sufficient JJ cord-262511-96xp1v0r 301 24 for for IN cord-262511-96xp1v0r 301 25 CD28-mediated cd28-mediated JJ cord-262511-96xp1v0r 301 26 stabilization stabilization NN cord-262511-96xp1v0r 301 27 of of IN cord-262511-96xp1v0r 301 28 the the DT cord-262511-96xp1v0r 301 29 mRNA mrna NN cord-262511-96xp1v0r 302 1 The the DT cord-262511-96xp1v0r 302 2 peptidylprolyl peptidylprolyl JJ cord-262511-96xp1v0r 302 3 isomerase isomerase NN cord-262511-96xp1v0r 302 4 pin1 pin1 NNP cord-262511-96xp1v0r 302 5 regulates regulate VBZ cord-262511-96xp1v0r 302 6 granulocyte granulocyte NN cord-262511-96xp1v0r 302 7 - - HYPH cord-262511-96xp1v0r 302 8 macrophage macrophage NN cord-262511-96xp1v0r 302 9 colony colony NN cord-262511-96xp1v0r 302 10 - - HYPH cord-262511-96xp1v0r 302 11 stimulating stimulate VBG cord-262511-96xp1v0r 302 12 factor factor NN cord-262511-96xp1v0r 302 13 mRNA mrna NN cord-262511-96xp1v0r 302 14 stability stability NN cord-262511-96xp1v0r 302 15 in in IN cord-262511-96xp1v0r 302 16 T t NN cord-262511-96xp1v0r 302 17 lymphocytes lymphocyte NNS cord-262511-96xp1v0r 303 1 The the DT cord-262511-96xp1v0r 303 2 peptidyl peptidyl JJ cord-262511-96xp1v0r 303 3 - - HYPH cord-262511-96xp1v0r 303 4 prolyl prolyl JJ cord-262511-96xp1v0r 303 5 isomerase isomerase NN cord-262511-96xp1v0r 303 6 Pin1 Pin1 NNP cord-262511-96xp1v0r 303 7 regulates regulate VBZ cord-262511-96xp1v0r 303 8 the the DT cord-262511-96xp1v0r 303 9 stability stability NN cord-262511-96xp1v0r 303 10 of of IN cord-262511-96xp1v0r 303 11 granulocyte granulocyte NN cord-262511-96xp1v0r 303 12 - - HYPH cord-262511-96xp1v0r 303 13 macrophage macrophage NN cord-262511-96xp1v0r 303 14 colony colony NN cord-262511-96xp1v0r 303 15 - - HYPH cord-262511-96xp1v0r 303 16 stimulating stimulate VBG cord-262511-96xp1v0r 303 17 factor factor NN cord-262511-96xp1v0r 304 1 mRNA mrna NN cord-262511-96xp1v0r 304 2 in in IN cord-262511-96xp1v0r 304 3 activated activate VBN cord-262511-96xp1v0r 304 4 eosinophils eosinophils NN cord-262511-96xp1v0r 304 5 Destabilization destabilization NN cord-262511-96xp1v0r 304 6 of of IN cord-262511-96xp1v0r 304 7 interleukin-6 interleukin-6 NNP cord-262511-96xp1v0r 305 1 mRNA mRNA NNP cord-262511-96xp1v0r 305 2 requires require VBZ cord-262511-96xp1v0r 305 3 a a DT cord-262511-96xp1v0r 305 4 putative putative JJ cord-262511-96xp1v0r 305 5 RNA RNA NNP cord-262511-96xp1v0r 305 6 stem stem NN cord-262511-96xp1v0r 305 7 - - HYPH cord-262511-96xp1v0r 305 8 loop loop NN cord-262511-96xp1v0r 305 9 structure structure NN cord-262511-96xp1v0r 305 10 , , , cord-262511-96xp1v0r 305 11 an an DT cord-262511-96xp1v0r 305 12 AU au NN cord-262511-96xp1v0r 305 13 - - HYPH cord-262511-96xp1v0r 305 14 rich rich JJ cord-262511-96xp1v0r 305 15 element element NN cord-262511-96xp1v0r 305 16 , , , cord-262511-96xp1v0r 305 17 and and CC cord-262511-96xp1v0r 305 18 the the DT cord-262511-96xp1v0r 305 19 RNAbinding rnabinding NN cord-262511-96xp1v0r 305 20 protein protein NN cord-262511-96xp1v0r 305 21 AUF1 AUF1 NNP cord-262511-96xp1v0r 305 22 HuA hua NN cord-262511-96xp1v0r 305 23 and and CC cord-262511-96xp1v0r 305 24 tristetraprolin tristetraprolin NNP cord-262511-96xp1v0r 305 25 are be VBP cord-262511-96xp1v0r 305 26 induced induce VBN cord-262511-96xp1v0r 305 27 following follow VBG cord-262511-96xp1v0r 305 28 T T NNP cord-262511-96xp1v0r 305 29 cell cell NN cord-262511-96xp1v0r 305 30 activation activation NN cord-262511-96xp1v0r 305 31 and and CC cord-262511-96xp1v0r 305 32 display display NN cord-262511-96xp1v0r 305 33 distinct distinct JJ cord-262511-96xp1v0r 305 34 but but CC cord-262511-96xp1v0r 305 35 overlapping overlap VBG cord-262511-96xp1v0r 305 36 RNA RNA NNP cord-262511-96xp1v0r 305 37 binding bind VBG cord-262511-96xp1v0r 305 38 specificities specificity NNS cord-262511-96xp1v0r 305 39 Activation Activation NNP cord-262511-96xp1v0r 305 40 of of IN cord-262511-96xp1v0r 305 41 the the DT cord-262511-96xp1v0r 305 42 integrated integrated JJ cord-262511-96xp1v0r 305 43 stress stress NN cord-262511-96xp1v0r 305 44 response response NN cord-262511-96xp1v0r 305 45 during during IN cord-262511-96xp1v0r 305 46 T T NNP cord-262511-96xp1v0r 305 47 helper helper NN cord-262511-96xp1v0r 305 48 cell cell NN cord-262511-96xp1v0r 305 49 differentiation differentiation NN cord-262511-96xp1v0r 305 50 RNA RNA NNP cord-262511-96xp1v0r 305 51 granules granule NNS cord-262511-96xp1v0r 305 52 The the DT cord-262511-96xp1v0r 305 53 p38 p38 CD cord-262511-96xp1v0r 305 54 mitogen mitogen NN cord-262511-96xp1v0r 305 55 - - HYPH cord-262511-96xp1v0r 305 56 activated activate VBN cord-262511-96xp1v0r 305 57 protein protein NN cord-262511-96xp1v0r 305 58 kinase kinase NN cord-262511-96xp1v0r 305 59 regulates regulate VBZ cord-262511-96xp1v0r 305 60 effector effector NN cord-262511-96xp1v0r 305 61 functions function NNS cord-262511-96xp1v0r 305 62 of of IN cord-262511-96xp1v0r 305 63 primary primary JJ cord-262511-96xp1v0r 305 64 human human JJ cord-262511-96xp1v0r 305 65 CD4 CD4 NNP cord-262511-96xp1v0r 305 66 T T NNP cord-262511-96xp1v0r 305 67 cells cell NNS cord-262511-96xp1v0r 305 68 Interferons interferon NNS cord-262511-96xp1v0r 306 1 limit limit VB cord-262511-96xp1v0r 306 2 inflammatory inflammatory JJ cord-262511-96xp1v0r 306 3 responses response NNS cord-262511-96xp1v0r 306 4 by by IN cord-262511-96xp1v0r 306 5 induction induction NN cord-262511-96xp1v0r 306 6 of of IN cord-262511-96xp1v0r 306 7 tristetraprolin tristetraprolin NNP cord-262511-96xp1v0r 306 8 Glucocorticoids Glucocorticoids NNP cord-262511-96xp1v0r 306 9 regulate regulate VBP cord-262511-96xp1v0r 306 10 tristetraprolin tristetraprolin NN cord-262511-96xp1v0r 306 11 synthesis synthesis NN cord-262511-96xp1v0r 306 12 and and CC cord-262511-96xp1v0r 306 13 posttranscriptionally posttranscriptionally RB cord-262511-96xp1v0r 306 14 regulate regulate VBP cord-262511-96xp1v0r 306 15 tumor tumor NN cord-262511-96xp1v0r 306 16 necrosis necrosis NN cord-262511-96xp1v0r 306 17 factor factor NN cord-262511-96xp1v0r 306 18 ␣ ␣ NFP cord-262511-96xp1v0r 306 19 inflammatory inflammatory JJ cord-262511-96xp1v0r 306 20 signaling signal VBG cord-262511-96xp1v0r 306 21 Inhibition inhibition NN cord-262511-96xp1v0r 306 22 of of IN cord-262511-96xp1v0r 306 23 tristetraprolin tristetraprolin NN cord-262511-96xp1v0r 306 24 expression expression NN cord-262511-96xp1v0r 306 25 by by IN cord-262511-96xp1v0r 306 26 dexamethasone dexamethasone NN cord-262511-96xp1v0r 306 27 in in IN cord-262511-96xp1v0r 306 28 activated activate VBN cord-262511-96xp1v0r 306 29 macrophages macrophage NNS cord-262511-96xp1v0r 307 1 IL-10-induced IL-10-induced NNP cord-262511-96xp1v0r 307 2 TNF- TNF- NNP cord-262511-96xp1v0r 308 1 ␣ ␣ NNP cord-262511-96xp1v0r 308 2 mRNA mRNA NNP cord-262511-96xp1v0r 308 3 destabilization destabilization NN cord-262511-96xp1v0r 308 4 is be VBZ cord-262511-96xp1v0r 308 5 mediated mediate VBN cord-262511-96xp1v0r 308 6 via via IN cord-262511-96xp1v0r 308 7 IL-10 IL-10 NNP cord-262511-96xp1v0r 308 8 suppression suppression NN cord-262511-96xp1v0r 308 9 of of IN cord-262511-96xp1v0r 308 10 p38 p38 NNP cord-262511-96xp1v0r 308 11 MAP MAP NNP cord-262511-96xp1v0r 308 12 kinase kinase NN cord-262511-96xp1v0r 308 13 activation activation NN cord-262511-96xp1v0r 308 14 and and CC cord-262511-96xp1v0r 308 15 inhibition inhibition NN cord-262511-96xp1v0r 308 16 of of IN cord-262511-96xp1v0r 308 17 HuR hur JJ cord-262511-96xp1v0r 308 18 expression expression NN cord-262511-96xp1v0r 308 19 IL-4 IL-4 NNP cord-262511-96xp1v0r 308 20 inhibits inhibit VBZ cord-262511-96xp1v0r 308 21 expression expression NN cord-262511-96xp1v0r 308 22 of of IN cord-262511-96xp1v0r 308 23 the the DT cord-262511-96xp1v0r 308 24 formyl formyl NNP cord-262511-96xp1v0r 308 25 peptide peptide NN cord-262511-96xp1v0r 308 26 receptor receptor NN cord-262511-96xp1v0r 308 27 gene gene NN cord-262511-96xp1v0r 308 28 in in IN cord-262511-96xp1v0r 308 29 mouse mouse NN cord-262511-96xp1v0r 308 30 peritoneal peritoneal NN cord-262511-96xp1v0r 308 31 macrophages macrophage NNS cord-262511-96xp1v0r 309 1 Negative negative JJ cord-262511-96xp1v0r 309 2 regulation regulation NN cord-262511-96xp1v0r 309 3 of of IN cord-262511-96xp1v0r 309 4 interleukin-2 interleukin-2 NN cord-262511-96xp1v0r 309 5 and and CC cord-262511-96xp1v0r 309 6 p38 p38 CD cord-262511-96xp1v0r 309 7 mitogen mitogen NN cord-262511-96xp1v0r 309 8 - - HYPH cord-262511-96xp1v0r 309 9 activated activate VBN cord-262511-96xp1v0r 309 10 protein protein NN cord-262511-96xp1v0r 309 11 kinase kinase NN cord-262511-96xp1v0r 309 12 during during IN cord-262511-96xp1v0r 309 13 T t NN cord-262511-96xp1v0r 309 14 - - HYPH cord-262511-96xp1v0r 309 15 cell cell NN cord-262511-96xp1v0r 309 16 activation activation NN cord-262511-96xp1v0r 309 17 by by IN cord-262511-96xp1v0r 309 18 the the DT cord-262511-96xp1v0r 309 19 adaptor adaptor NN cord-262511-96xp1v0r 309 20 ALX ALX NNP cord-262511-96xp1v0r 309 21 ) ) -RRB- cord-262511-96xp1v0r 309 22 T t NN cord-262511-96xp1v0r 309 23 cell cell NN cord-262511-96xp1v0r 309 24 lineage lineage NN cord-262511-96xp1v0r 309 25 choice choice NN cord-262511-96xp1v0r 309 26 and and CC cord-262511-96xp1v0r 309 27 differentiation differentiation NN cord-262511-96xp1v0r 309 28 in in IN cord-262511-96xp1v0r 309 29 the the DT cord-262511-96xp1v0r 309 30 absence absence NN cord-262511-96xp1v0r 309 31 of of IN cord-262511-96xp1v0r 309 32 the the DT cord-262511-96xp1v0r 309 33 RNase RNase NNP cord-262511-96xp1v0r 309 34 III III NNP cord-262511-96xp1v0r 309 35 enzyme enzyme NN cord-262511-96xp1v0r 309 36 dicer dicer NN cord-262511-96xp1v0r 309 37 A a DT cord-262511-96xp1v0r 309 38 role role NN cord-262511-96xp1v0r 309 39 for for IN cord-262511-96xp1v0r 309 40 dicer dicer NN cord-262511-96xp1v0r 309 41 in in IN cord-262511-96xp1v0r 309 42 immune immune JJ cord-262511-96xp1v0r 309 43 regulation regulation NN cord-262511-96xp1v0r 309 44 Aberrant aberrant JJ cord-262511-96xp1v0r 309 45 T t NN cord-262511-96xp1v0r 309 46 cell cell NN cord-262511-96xp1v0r 309 47 differentiation differentiation NN cord-262511-96xp1v0r 309 48 in in IN cord-262511-96xp1v0r 309 49 the the DT cord-262511-96xp1v0r 309 50 absence absence NN cord-262511-96xp1v0r 309 51 of of IN cord-262511-96xp1v0r 309 52 dicer dicer NN cord-262511-96xp1v0r 309 53 NF-{}B nf-{}b NN cord-262511-96xp1v0r 309 54 - - HYPH cord-262511-96xp1v0r 309 55 dependent dependent JJ cord-262511-96xp1v0r 309 56 induction induction NN cord-262511-96xp1v0r 309 57 of of IN cord-262511-96xp1v0r 309 58 microRNA microRNA NNP cord-262511-96xp1v0r 309 59 miR-146 miR-146 NNP cord-262511-96xp1v0r 309 60 , , , cord-262511-96xp1v0r 309 61 an an DT cord-262511-96xp1v0r 309 62 inhibitor inhibitor NN cord-262511-96xp1v0r 309 63 targeted target VBN cord-262511-96xp1v0r 309 64 to to IN cord-262511-96xp1v0r 309 65 signaling signal VBG cord-262511-96xp1v0r 309 66 proteins protein NNS cord-262511-96xp1v0r 309 67 of of IN cord-262511-96xp1v0r 309 68 innate innate JJ cord-262511-96xp1v0r 309 69 immune immune JJ cord-262511-96xp1v0r 309 70 responses response NNS cord-262511-96xp1v0r 309 71 Involvement Involvement NNP cord-262511-96xp1v0r 309 72 of of IN cord-262511-96xp1v0r 309 73 mi mi NNP cord-262511-96xp1v0r 309 74 - - HYPH cord-262511-96xp1v0r 309 75 croRNA croRNA NNP cord-262511-96xp1v0r 309 76 in in IN cord-262511-96xp1v0r 309 77 AU AU NNP cord-262511-96xp1v0r 309 78 - - HYPH cord-262511-96xp1v0r 309 79 rich rich JJ cord-262511-96xp1v0r 309 80 element element NN cord-262511-96xp1v0r 309 81 - - HYPH cord-262511-96xp1v0r 309 82 mediated mediate VBN cord-262511-96xp1v0r 309 83 mRNA mrna NN cord-262511-96xp1v0r 309 84 instability instability NN cord-262511-96xp1v0r 309 85 MicroRNA-155 MicroRNA-155 NNP cord-262511-96xp1v0r 309 86 is be VBZ cord-262511-96xp1v0r 309 87 induced induce VBN cord-262511-96xp1v0r 309 88 during during IN cord-262511-96xp1v0r 309 89 the the DT cord-262511-96xp1v0r 309 90 macrophage macrophage NN cord-262511-96xp1v0r 309 91 inflammatory inflammatory JJ cord-262511-96xp1v0r 309 92 response response NN cord-262511-96xp1v0r 309 93 Suppression Suppression NNP cord-262511-96xp1v0r 309 94 of of IN cord-262511-96xp1v0r 309 95 microRNA microRNA NNP cord-262511-96xp1v0r 309 96 - - HYPH cord-262511-96xp1v0r 309 97 silencing silence VBG cord-262511-96xp1v0r 309 98 pathway pathway NN cord-262511-96xp1v0r 309 99 by by IN cord-262511-96xp1v0r 309 100 HIV-1 HIV-1 NNP cord-262511-96xp1v0r 309 101 during during IN cord-262511-96xp1v0r 309 102 virus virus NN cord-262511-96xp1v0r 309 103 replication replication NN cord-262511-96xp1v0r 309 104 Human human JJ cord-262511-96xp1v0r 309 105 immunodeficiency immunodeficiency NN cord-262511-96xp1v0r 309 106 virus virus NN cord-262511-96xp1v0r 309 107 type type NN cord-262511-96xp1v0r 310 1 1 1 CD cord-262511-96xp1v0r 310 2 Tat tat NN cord-262511-96xp1v0r 310 3 protein protein NN cord-262511-96xp1v0r 310 4 induces induce VBZ cord-262511-96xp1v0r 310 5 an an DT cord-262511-96xp1v0r 310 6 intracellular intracellular JJ cord-262511-96xp1v0r 310 7 calcium calcium NN cord-262511-96xp1v0r 310 8 increase increase NN cord-262511-96xp1v0r 310 9 in in IN cord-262511-96xp1v0r 310 10 human human JJ cord-262511-96xp1v0r 310 11 monocytes monocyte NNS cord-262511-96xp1v0r 310 12 that that WDT cord-262511-96xp1v0r 310 13 requires require VBZ cord-262511-96xp1v0r 310 14 DHP DHP NNP cord-262511-96xp1v0r 310 15 receptors receptor NNS cord-262511-96xp1v0r 310 16 : : : cord-262511-96xp1v0r 310 17 involvement involvement NN cord-262511-96xp1v0r 310 18 in in IN cord-262511-96xp1v0r 310 19 TNF- TNF- NNP cord-262511-96xp1v0r 310 20 ␣ ␣ NN cord-262511-96xp1v0r 310 21 production production NN