id	sid	tid	token	lemma	pos
cord-275730-650sjwyy	1	1	key	key	JJ
cord-275730-650sjwyy	1	2	:	:	:
cord-275730-650sjwyy	1	3	cord-275730	cord-275730	NNP
cord-275730-650sjwyy	1	4	-	-	HYPH
cord-275730-650sjwyy	1	5	650sjwyy	650sjwyy	NNP
cord-275730-650sjwyy	1	6	authors	author	NNS
cord-275730-650sjwyy	1	7	:	:	:
cord-275730-650sjwyy	1	8	Gogoi	Gogoi	NNP
cord-275730-650sjwyy	1	9	,	,	,
cord-275730-650sjwyy	1	10	Himanshu	Himanshu	NNP
cord-275730-650sjwyy	1	11	;	;	:
cord-275730-650sjwyy	1	12	Mansouri	Mansouri	NNP
cord-275730-650sjwyy	1	13	,	,	,
cord-275730-650sjwyy	1	14	Samira	Samira	NNP
cord-275730-650sjwyy	1	15	;	;	:
cord-275730-650sjwyy	1	16	Jin	Jin	NNP
cord-275730-650sjwyy	1	17	,	,	,
cord-275730-650sjwyy	1	18	Lei	Lei	NNP
cord-275730-650sjwyy	1	19	title	title	NN
cord-275730-650sjwyy	1	20	:	:	:
cord-275730-650sjwyy	1	21	The	the	DT
cord-275730-650sjwyy	1	22	Age	Age	NNP
cord-275730-650sjwyy	1	23	of	of	IN
cord-275730-650sjwyy	1	24	Cyclic	Cyclic	NNP
cord-275730-650sjwyy	1	25	Dinucleotide	Dinucleotide	NNP
cord-275730-650sjwyy	1	26	Vaccine	Vaccine	NNP
cord-275730-650sjwyy	1	27	Adjuvants	Adjuvants	NNP
cord-275730-650sjwyy	1	28	date	date	NN
cord-275730-650sjwyy	1	29	:	:	:
cord-275730-650sjwyy	1	30	2020	2020	CD
cord-275730-650sjwyy	1	31	-	-	HYPH
cord-275730-650sjwyy	1	32	08	08	CD
cord-275730-650sjwyy	1	33	-	-	SYM
cord-275730-650sjwyy	1	34	13	13	CD
cord-275730-650sjwyy	1	35	journal	journal	NN
cord-275730-650sjwyy	1	36	:	:	:
cord-275730-650sjwyy	2	1	Vaccines	vaccine	NNS
cord-275730-650sjwyy	2	2	(	(	-LRB-
cord-275730-650sjwyy	2	3	Basel	Basel	NNP
cord-275730-650sjwyy	2	4	)	)	-RRB-
cord-275730-650sjwyy	2	5	DOI	DOI	NNP
cord-275730-650sjwyy	2	6	:	:	:
cord-275730-650sjwyy	3	1	10.3390	10.3390	CD
cord-275730-650sjwyy	3	2	/	/	SYM
cord-275730-650sjwyy	3	3	vaccines8030453	vaccines8030453	CD
cord-275730-650sjwyy	3	4	sha	sha	NNP
cord-275730-650sjwyy	3	5	:	:	:
cord-275730-650sjwyy	4	1	6783da11ffa8b469472f64eec1a2d7fb75d4dbae	6783da11ffa8b469472f64eec1a2d7fb75d4dbae	CD
cord-275730-650sjwyy	4	2	doc_id	doc_id	CD
cord-275730-650sjwyy	4	3	:	:	:
cord-275730-650sjwyy	4	4	275730	275730	CD
cord-275730-650sjwyy	4	5	cord_uid	cord_uid	NNS
cord-275730-650sjwyy	4	6	:	:	:
cord-275730-650sjwyy	4	7	650sjwyy	650sjwyy	NNP
cord-275730-650sjwyy	5	1	As	as	IN
cord-275730-650sjwyy	5	2	prophylactic	prophylactic	JJ
cord-275730-650sjwyy	5	3	vaccine	vaccine	NN
cord-275730-650sjwyy	5	4	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	5	5	for	for	IN
cord-275730-650sjwyy	5	6	infectious	infectious	JJ
cord-275730-650sjwyy	5	7	diseases	disease	NNS
cord-275730-650sjwyy	5	8	,	,	,
cord-275730-650sjwyy	5	9	cyclic	cyclic	JJ
cord-275730-650sjwyy	5	10	dinucleotides	dinucleotide	NNS
cord-275730-650sjwyy	5	11	(	(	-LRB-
cord-275730-650sjwyy	5	12	CDNs	CDNs	NNP
cord-275730-650sjwyy	5	13	)	)	-RRB-
cord-275730-650sjwyy	5	14	induce	induce	VBP
cord-275730-650sjwyy	5	15	safe	safe	JJ
cord-275730-650sjwyy	5	16	,	,	,
cord-275730-650sjwyy	5	17	potent	potent	JJ
cord-275730-650sjwyy	5	18	,	,	,
cord-275730-650sjwyy	5	19	long	long	RB
cord-275730-650sjwyy	5	20	-	-	HYPH
cord-275730-650sjwyy	5	21	lasting	last	VBG
cord-275730-650sjwyy	5	22	humoral	humoral	JJ
cord-275730-650sjwyy	5	23	and	and	CC
cord-275730-650sjwyy	5	24	cellular	cellular	JJ
cord-275730-650sjwyy	5	25	memory	memory	NN
cord-275730-650sjwyy	5	26	responses	response	NNS
cord-275730-650sjwyy	5	27	in	in	IN
cord-275730-650sjwyy	5	28	the	the	DT
cord-275730-650sjwyy	5	29	systemic	systemic	JJ
cord-275730-650sjwyy	5	30	and	and	CC
cord-275730-650sjwyy	5	31	mucosal	mucosal	JJ
cord-275730-650sjwyy	5	32	compartments	compartment	NNS
cord-275730-650sjwyy	5	33	.	.	.
cord-275730-650sjwyy	6	1	As	as	IN
cord-275730-650sjwyy	6	2	therapeutic	therapeutic	JJ
cord-275730-650sjwyy	6	3	cancer	cancer	NN
cord-275730-650sjwyy	6	4	vaccine	vaccine	NN
cord-275730-650sjwyy	6	5	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	6	6	,	,	,
cord-275730-650sjwyy	6	7	CDNs	cdn	NNS
cord-275730-650sjwyy	6	8	induce	induce	VBP
cord-275730-650sjwyy	6	9	potent	potent	JJ
cord-275730-650sjwyy	6	10	anti	anti	JJ
cord-275730-650sjwyy	6	11	-	-	JJ
cord-275730-650sjwyy	6	12	tumor	tumor	JJ
cord-275730-650sjwyy	6	13	immunity	immunity	NN
cord-275730-650sjwyy	6	14	,	,	,
cord-275730-650sjwyy	6	15	including	include	VBG
cord-275730-650sjwyy	6	16	cytotoxic	cytotoxic	JJ
cord-275730-650sjwyy	6	17	T	t	NN
cord-275730-650sjwyy	6	18	cells	cell	NNS
cord-275730-650sjwyy	6	19	and	and	CC
cord-275730-650sjwyy	6	20	NK	NK	NNP
cord-275730-650sjwyy	6	21	cells	cell	NNS
cord-275730-650sjwyy	6	22	activation	activation	NN
cord-275730-650sjwyy	6	23	that	that	WDT
cord-275730-650sjwyy	6	24	achieve	achieve	VBP
cord-275730-650sjwyy	6	25	durable	durable	JJ
cord-275730-650sjwyy	6	26	regression	regression	NN
cord-275730-650sjwyy	6	27	in	in	IN
cord-275730-650sjwyy	6	28	multiple	multiple	JJ
cord-275730-650sjwyy	6	29	mouse	mouse	NN
cord-275730-650sjwyy	6	30	models	model	NNS
cord-275730-650sjwyy	6	31	of	of	IN
cord-275730-650sjwyy	6	32	tumors	tumor	NNS
cord-275730-650sjwyy	6	33	.	.	.
cord-275730-650sjwyy	7	1	Clinical	clinical	JJ
cord-275730-650sjwyy	7	2	trials	trial	NNS
cord-275730-650sjwyy	7	3	are	be	VBP
cord-275730-650sjwyy	7	4	ongoing	ongoing	JJ
cord-275730-650sjwyy	7	5	to	to	TO
cord-275730-650sjwyy	7	6	fulfill	fulfill	VB
cord-275730-650sjwyy	7	7	the	the	DT
cord-275730-650sjwyy	7	8	promise	promise	NN
cord-275730-650sjwyy	7	9	of	of	IN
cord-275730-650sjwyy	7	10	CDNs	CDNs	NNP
cord-275730-650sjwyy	7	11	(	(	-LRB-
cord-275730-650sjwyy	7	12	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-275730-650sjwyy	7	13	:	:	:
cord-275730-650sjwyy	7	14	NCT02675439	nct02675439	UH
cord-275730-650sjwyy	7	15	,	,	,
cord-275730-650sjwyy	7	16	NCT03010176	NCT03010176	NNP
cord-275730-650sjwyy	7	17	,	,	,
cord-275730-650sjwyy	7	18	NCT03172936	NCT03172936	NNP
cord-275730-650sjwyy	7	19	,	,	,
cord-275730-650sjwyy	7	20	and	and	CC
cord-275730-650sjwyy	7	21	NCT03937141	NCT03937141	NNP
cord-275730-650sjwyy	7	22	)	)	-RRB-
cord-275730-650sjwyy	7	23	.	.	.
cord-275730-650sjwyy	8	1	However	however	RB
cord-275730-650sjwyy	8	2	,	,	,
cord-275730-650sjwyy	8	3	in	in	IN
cord-275730-650sjwyy	8	4	October	October	NNP
cord-275730-650sjwyy	8	5	2018	2018	CD
cord-275730-650sjwyy	8	6	,	,	,
cord-275730-650sjwyy	8	7	the	the	DT
cord-275730-650sjwyy	8	8	first	first	JJ
cord-275730-650sjwyy	8	9	clinical	clinical	JJ
cord-275730-650sjwyy	8	10	data	datum	NNS
cord-275730-650sjwyy	8	11	with	with	IN
cord-275730-650sjwyy	8	12	Merck	Merck	NNP
cord-275730-650sjwyy	8	13	’s	’s	POS
cord-275730-650sjwyy	8	14	CDN	CDN	NNP
cord-275730-650sjwyy	8	15	MK-1454	MK-1454	NNP
cord-275730-650sjwyy	8	16	showed	show	VBD
cord-275730-650sjwyy	8	17	zero	zero	CD
cord-275730-650sjwyy	8	18	activity	activity	NN
cord-275730-650sjwyy	8	19	as	as	IN
cord-275730-650sjwyy	8	20	a	a	DT
cord-275730-650sjwyy	8	21	monotherapy	monotherapy	NN
cord-275730-650sjwyy	8	22	in	in	IN
cord-275730-650sjwyy	8	23	patients	patient	NNS
cord-275730-650sjwyy	8	24	with	with	IN
cord-275730-650sjwyy	8	25	solid	solid	JJ
cord-275730-650sjwyy	8	26	tumors	tumor	NNS
cord-275730-650sjwyy	8	27	or	or	CC
cord-275730-650sjwyy	8	28	lymphomas	lymphoma	NNS
cord-275730-650sjwyy	8	29	(	(	-LRB-
cord-275730-650sjwyy	8	30	NCT03010176	NCT03010176	NNP
cord-275730-650sjwyy	8	31	)	)	-RRB-
cord-275730-650sjwyy	8	32	.	.	.
cord-275730-650sjwyy	9	1	Lately	lately	RB
cord-275730-650sjwyy	9	2	,	,	,
cord-275730-650sjwyy	9	3	the	the	DT
cord-275730-650sjwyy	9	4	clinical	clinical	JJ
cord-275730-650sjwyy	9	5	trial	trial	NN
cord-275730-650sjwyy	9	6	from	from	IN
cord-275730-650sjwyy	9	7	Aduro	Aduro	NNP
cord-275730-650sjwyy	9	8	’s	’s	POS
cord-275730-650sjwyy	9	9	CDN	CDN	NNP
cord-275730-650sjwyy	9	10	ADU	ADU	NNP
cord-275730-650sjwyy	9	11	-	-	HYPH
cord-275730-650sjwyy	9	12	S100	S100	NNP
cord-275730-650sjwyy	9	13	monotherapy	monotherapy	NN
cord-275730-650sjwyy	9	14	was	be	VBD
cord-275730-650sjwyy	9	15	also	also	RB
cord-275730-650sjwyy	9	16	disappointing	disappointing	JJ
cord-275730-650sjwyy	9	17	(	(	-LRB-
cord-275730-650sjwyy	9	18	NCT03172936	NCT03172936	NNP
cord-275730-650sjwyy	9	19	)	)	-RRB-
cord-275730-650sjwyy	9	20	.	.	.
cord-275730-650sjwyy	10	1	The	the	DT
cord-275730-650sjwyy	10	2	emerging	emerge	VBG
cord-275730-650sjwyy	10	3	hurdle	hurdle	NN
cord-275730-650sjwyy	10	4	in	in	IN
cord-275730-650sjwyy	10	5	CDN	CDN	NNP
cord-275730-650sjwyy	10	6	vaccine	vaccine	NN
cord-275730-650sjwyy	10	7	development	development	NN
cord-275730-650sjwyy	10	8	calls	call	VBZ
cord-275730-650sjwyy	10	9	for	for	IN
cord-275730-650sjwyy	10	10	a	a	DT
cord-275730-650sjwyy	10	11	timely	timely	JJ
cord-275730-650sjwyy	10	12	re	re	NN
cord-275730-650sjwyy	10	13	-	-	NN
cord-275730-650sjwyy	10	14	evaluation	evaluation	NN
cord-275730-650sjwyy	10	15	of	of	IN
cord-275730-650sjwyy	10	16	our	-PRON-	PRP$
cord-275730-650sjwyy	10	17	understanding	understanding	NN
cord-275730-650sjwyy	10	18	on	on	IN
cord-275730-650sjwyy	10	19	CDN	CDN	NNP
cord-275730-650sjwyy	10	20	vaccine	vaccine	NN
cord-275730-650sjwyy	10	21	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	10	22	.	.	.
cord-275730-650sjwyy	11	1	Here	here	RB
cord-275730-650sjwyy	11	2	,	,	,
cord-275730-650sjwyy	11	3	we	-PRON-	PRP
cord-275730-650sjwyy	11	4	review	review	VBP
cord-275730-650sjwyy	11	5	the	the	DT
cord-275730-650sjwyy	11	6	status	status	NN
cord-275730-650sjwyy	11	7	of	of	IN
cord-275730-650sjwyy	11	8	CDN	CDN	NNP
cord-275730-650sjwyy	11	9	vaccine	vaccine	NN
cord-275730-650sjwyy	11	10	adjuvant	adjuvant	NN
cord-275730-650sjwyy	11	11	research	research	NN
cord-275730-650sjwyy	11	12	,	,	,
cord-275730-650sjwyy	11	13	including	include	VBG
cord-275730-650sjwyy	11	14	their	-PRON-	PRP$
cord-275730-650sjwyy	11	15	superior	superior	JJ
cord-275730-650sjwyy	11	16	adjuvant	adjuvant	NN
cord-275730-650sjwyy	11	17	activities	activity	NNS
cord-275730-650sjwyy	11	18	,	,	,
cord-275730-650sjwyy	11	19	in	in	IN
cord-275730-650sjwyy	11	20	vivo	vivo	NN
cord-275730-650sjwyy	11	21	mode	mode	NN
cord-275730-650sjwyy	11	22	of	of	IN
cord-275730-650sjwyy	11	23	action	action	NN
cord-275730-650sjwyy	11	24	,	,	,
cord-275730-650sjwyy	11	25	and	and	CC
cord-275730-650sjwyy	11	26	confounding	confounding	JJ
cord-275730-650sjwyy	11	27	factors	factor	NNS
cord-275730-650sjwyy	11	28	that	that	WDT
cord-275730-650sjwyy	11	29	affect	affect	VBP
cord-275730-650sjwyy	11	30	their	-PRON-	PRP$
cord-275730-650sjwyy	11	31	efficacy	efficacy	NN
cord-275730-650sjwyy	11	32	in	in	IN
cord-275730-650sjwyy	11	33	humans	human	NNS
cord-275730-650sjwyy	11	34	.	.	.
cord-275730-650sjwyy	12	1	Lastly	lastly	RB
cord-275730-650sjwyy	12	2	,	,	,
cord-275730-650sjwyy	12	3	we	-PRON-	PRP
cord-275730-650sjwyy	12	4	discuss	discuss	VBP
cord-275730-650sjwyy	12	5	the	the	DT
cord-275730-650sjwyy	12	6	strategies	strategy	NNS
cord-275730-650sjwyy	12	7	to	to	TO
cord-275730-650sjwyy	12	8	overcome	overcome	VB
cord-275730-650sjwyy	12	9	the	the	DT
cord-275730-650sjwyy	12	10	hurdle	hurdle	NN
cord-275730-650sjwyy	12	11	and	and	CC
cord-275730-650sjwyy	12	12	advance	advance	VB
cord-275730-650sjwyy	12	13	promising	promising	JJ
cord-275730-650sjwyy	12	14	CDN	CDN	NNP
cord-275730-650sjwyy	12	15	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	12	16	in	in	IN
cord-275730-650sjwyy	12	17	humans	human	NNS
cord-275730-650sjwyy	12	18	.	.	.
cord-275730-650sjwyy	13	1	Vaccines	vaccine	NNS
cord-275730-650sjwyy	13	2	,	,	,
cord-275730-650sjwyy	13	3	by	by	IN
cord-275730-650sjwyy	13	4	no	no	DT
cord-275730-650sjwyy	13	5	doubt	doubt	NN
cord-275730-650sjwyy	13	6	,	,	,
cord-275730-650sjwyy	13	7	are	be	VBP
cord-275730-650sjwyy	13	8	one	one	CD
cord-275730-650sjwyy	13	9	of	of	IN
cord-275730-650sjwyy	13	10	the	the	DT
cord-275730-650sjwyy	13	11	most	most	RBS
cord-275730-650sjwyy	13	12	crowning	crowning	JJ
cord-275730-650sjwyy	13	13	achievements	achievement	NNS
cord-275730-650sjwyy	13	14	of	of	IN
cord-275730-650sjwyy	13	15	medical	medical	JJ
cord-275730-650sjwyy	13	16	science	science	NN
cord-275730-650sjwyy	13	17	.	.	.
cord-275730-650sjwyy	14	1	The	the	DT
cord-275730-650sjwyy	14	2	success	success	NN
cord-275730-650sjwyy	14	3	of	of	IN
cord-275730-650sjwyy	14	4	Edward	Edward	NNP
cord-275730-650sjwyy	14	5	Jenner	Jenner	NNP
cord-275730-650sjwyy	14	6	's	's	POS
cord-275730-650sjwyy	14	7	smallpox	smallpox	NN
cord-275730-650sjwyy	14	8	vaccine	vaccine	NN
cord-275730-650sjwyy	14	9	and	and	CC
cord-275730-650sjwyy	14	10	Louis	Louis	NNP
cord-275730-650sjwyy	14	11	Pasteur	Pasteur	NNP
cord-275730-650sjwyy	14	12	's	's	POS
cord-275730-650sjwyy	14	13	anthrax	anthrax	NN
cord-275730-650sjwyy	14	14	and	and	CC
cord-275730-650sjwyy	14	15	rabies	rabies	NN
cord-275730-650sjwyy	14	16	vaccines	vaccine	NNS
cord-275730-650sjwyy	14	17	demonstrated	demonstrate	VBD
cord-275730-650sjwyy	14	18	the	the	DT
cord-275730-650sjwyy	14	19	protection	protection	NN
cord-275730-650sjwyy	14	20	from	from	IN
cord-275730-650sjwyy	14	21	the	the	DT
cord-275730-650sjwyy	14	22	disease	disease	NN
cord-275730-650sjwyy	14	23	without	without	IN
cord-275730-650sjwyy	14	24	transferring	transfer	VBG
cord-275730-650sjwyy	14	25	the	the	DT
cord-275730-650sjwyy	14	26	disease	disease	NN
cord-275730-650sjwyy	14	27	itself	-PRON-	PRP
cord-275730-650sjwyy	14	28	.	.	.
cord-275730-650sjwyy	15	1	These	these	DT
cord-275730-650sjwyy	15	2	pioneer	pioneer	NN
cord-275730-650sjwyy	15	3	works	work	NNS
cord-275730-650sjwyy	15	4	lay	lie	VBD
cord-275730-650sjwyy	15	5	the	the	DT
cord-275730-650sjwyy	15	6	foundation	foundation	NN
cord-275730-650sjwyy	15	7	for	for	IN
cord-275730-650sjwyy	15	8	immunology	immunology	NN
cord-275730-650sjwyy	15	9	as	as	IN
cord-275730-650sjwyy	15	10	Edward	Edward	NNP
cord-275730-650sjwyy	15	11	Jenner	Jenner	NNP
cord-275730-650sjwyy	15	12	is	be	VBZ
cord-275730-650sjwyy	15	13	considered	consider	VBN
cord-275730-650sjwyy	15	14	the	the	DT
cord-275730-650sjwyy	15	15	father	father	NN
cord-275730-650sjwyy	15	16	of	of	IN
cord-275730-650sjwyy	15	17	immunology	immunology	NNP
cord-275730-650sjwyy	15	18	.	.	.
cord-275730-650sjwyy	16	1	Vaccine	vaccine	NN
cord-275730-650sjwyy	16	2	development	development	NN
cord-275730-650sjwyy	16	3	has	have	VBZ
cord-275730-650sjwyy	16	4	come	come	VBN
cord-275730-650sjwyy	16	5	a	a	DT
cord-275730-650sjwyy	16	6	long	long	JJ
cord-275730-650sjwyy	16	7	way	way	NN
cord-275730-650sjwyy	16	8	since	since	IN
cord-275730-650sjwyy	16	9	then	then	RB
cord-275730-650sjwyy	16	10	and	and	CC
cord-275730-650sjwyy	16	11	significantly	significantly	RB
cord-275730-650sjwyy	16	12	reduced	reduce	VBN
cord-275730-650sjwyy	16	13	disease	disease	NN
cord-275730-650sjwyy	16	14	burden	burden	NN
cord-275730-650sjwyy	16	15	worldwide	worldwide	RB
cord-275730-650sjwyy	16	16	.	.	.
cord-275730-650sjwyy	17	1	Today	today	NN
cord-275730-650sjwyy	17	2	,	,	,
cord-275730-650sjwyy	17	3	a	a	DT
cord-275730-650sjwyy	17	4	new	new	JJ
cord-275730-650sjwyy	17	5	era	era	NN
cord-275730-650sjwyy	17	6	of	of	IN
cord-275730-650sjwyy	17	7	recombinant	recombinant	JJ
cord-275730-650sjwyy	17	8	and	and	CC
cord-275730-650sjwyy	17	9	subunit	subunit	NN
cord-275730-650sjwyy	17	10	vaccines	vaccine	NNS
cord-275730-650sjwyy	17	11	with	with	IN
cord-275730-650sjwyy	17	12	improved	improve	VBN
cord-275730-650sjwyy	17	13	reactogenicity	reactogenicity	NN
cord-275730-650sjwyy	17	14	and	and	CC
cord-275730-650sjwyy	17	15	safety	safety	NN
cord-275730-650sjwyy	17	16	profile	profile	NN
cord-275730-650sjwyy	17	17	has	have	VBZ
cord-275730-650sjwyy	17	18	emerged	emerge	VBN
cord-275730-650sjwyy	17	19	.	.	.
cord-275730-650sjwyy	18	1	However	however	RB
cord-275730-650sjwyy	18	2	,	,	,
cord-275730-650sjwyy	18	3	these	these	DT
cord-275730-650sjwyy	18	4	new	new	JJ
cord-275730-650sjwyy	18	5	generations	generation	NNS
cord-275730-650sjwyy	18	6	of	of	IN
cord-275730-650sjwyy	18	7	vaccines	vaccine	NNS
cord-275730-650sjwyy	18	8	require	require	VBP
cord-275730-650sjwyy	18	9	the	the	DT
cord-275730-650sjwyy	18	10	addition	addition	NN
cord-275730-650sjwyy	18	11	of	of	IN
cord-275730-650sjwyy	18	12	an	an	DT
cord-275730-650sjwyy	18	13	adjuvant	adjuvant	NN
cord-275730-650sjwyy	18	14	to	to	TO
cord-275730-650sjwyy	18	15	enhance	enhance	VB
cord-275730-650sjwyy	18	16	their	-PRON-	PRP$
cord-275730-650sjwyy	18	17	vaccine	vaccine	NN
cord-275730-650sjwyy	18	18	property	property	NN
cord-275730-650sjwyy	18	19	.	.	.
cord-275730-650sjwyy	19	1	Vaccine	vaccine	NN
cord-275730-650sjwyy	19	2	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	19	3	determine	determine	VBP
cord-275730-650sjwyy	19	4	the	the	DT
cord-275730-650sjwyy	19	5	magnitude	magnitude	NN
cord-275730-650sjwyy	19	6	and	and	CC
cord-275730-650sjwyy	19	7	quality	quality	NN
cord-275730-650sjwyy	19	8	of	of	IN
cord-275730-650sjwyy	19	9	vaccine	vaccine	NN
cord-275730-650sjwyy	19	10	responses	response	NNS
cord-275730-650sjwyy	19	11	while	while	IN
cord-275730-650sjwyy	19	12	maintaining	maintain	VBG
cord-275730-650sjwyy	19	13	a	a	DT
cord-275730-650sjwyy	19	14	safety	safety	NN
cord-275730-650sjwyy	19	15	profile	profile	NN
cord-275730-650sjwyy	19	16	.	.	.
cord-275730-650sjwyy	20	1	Since	since	IN
cord-275730-650sjwyy	20	2	its	-PRON-	PRP$
cord-275730-650sjwyy	20	3	discovery	discovery	NN
cord-275730-650sjwyy	20	4	by	by	IN
cord-275730-650sjwyy	20	5	Alexander	Alexander	NNP
cord-275730-650sjwyy	20	6	Thomas	Thomas	NNP
cord-275730-650sjwyy	20	7	Glenny	Glenny	NNP
cord-275730-650sjwyy	20	8	in	in	IN
cord-275730-650sjwyy	20	9	the	the	DT
cord-275730-650sjwyy	20	10	1930s	1930	NNS
cord-275730-650sjwyy	20	11	,	,	,
cord-275730-650sjwyy	20	12	alum	alum	NN
cord-275730-650sjwyy	20	13	is	be	VBZ
cord-275730-650sjwyy	20	14	the	the	DT
cord-275730-650sjwyy	20	15	choice	choice	NN
cord-275730-650sjwyy	20	16	of	of	IN
cord-275730-650sjwyy	20	17	an	an	DT
cord-275730-650sjwyy	20	18	adjuvant	adjuvant	NN
cord-275730-650sjwyy	20	19	in	in	IN
cord-275730-650sjwyy	20	20	commercially	commercially	RB
cord-275730-650sjwyy	20	21	available	available	JJ
cord-275730-650sjwyy	20	22	vaccines	vaccine	NNS
cord-275730-650sjwyy	20	23	[	[	-LRB-
cord-275730-650sjwyy	20	24	1	1	CD
cord-275730-650sjwyy	20	25	]	]	-RRB-
cord-275730-650sjwyy	20	26	.	.	.
cord-275730-650sjwyy	21	1	As	as	IN
cord-275730-650sjwyy	21	2	a	a	DT
cord-275730-650sjwyy	21	3	vaccine	vaccine	NN
cord-275730-650sjwyy	21	4	adjuvant	adjuvant	NN
cord-275730-650sjwyy	21	5	,	,	,
cord-275730-650sjwyy	21	6	alum	alum	NN
cord-275730-650sjwyy	21	7	enhances	enhance	VBZ
cord-275730-650sjwyy	21	8	antibody	antibody	NN
cord-275730-650sjwyy	21	9	production	production	NN
cord-275730-650sjwyy	21	10	but	but	CC
cord-275730-650sjwyy	21	11	is	be	VBZ
cord-275730-650sjwyy	21	12	limited	limit	VBN
cord-275730-650sjwyy	21	13	to	to	IN
cord-275730-650sjwyy	21	14	the	the	DT
cord-275730-650sjwyy	21	15	Th2	th2	CD
cord-275730-650sjwyy	21	16	response	response	NN
cord-275730-650sjwyy	21	17	,	,	,
cord-275730-650sjwyy	21	18	which	which	WDT
cord-275730-650sjwyy	21	19	is	be	VBZ
cord-275730-650sjwyy	21	20	not	not	RB
cord-275730-650sjwyy	21	21	adequate	adequate	JJ
cord-275730-650sjwyy	21	22	for	for	IN
cord-275730-650sjwyy	21	23	the	the	DT
cord-275730-650sjwyy	21	24	protection	protection	NN
cord-275730-650sjwyy	21	25	from	from	IN
cord-275730-650sjwyy	21	26	intracellular	intracellular	JJ
cord-275730-650sjwyy	21	27	pathogens	pathogen	NNS
cord-275730-650sjwyy	21	28	that	that	WDT
cord-275730-650sjwyy	21	29	require	require	VBP
cord-275730-650sjwyy	21	30	Th1	th1	NN
cord-275730-650sjwyy	21	31	and	and	CC
cord-275730-650sjwyy	21	32	CD8	CD8	NNP
cord-275730-650sjwyy	21	33	+	+	CC
cord-275730-650sjwyy	21	34	cytotoxic	cytotoxic	JJ
cord-275730-650sjwyy	21	35	T	t	NN
cord-275730-650sjwyy	21	36	cell	cell	NN
cord-275730-650sjwyy	21	37	responses	response	NNS
cord-275730-650sjwyy	21	38	.	.	.
cord-275730-650sjwyy	22	1	Despite	despite	IN
cord-275730-650sjwyy	22	2	intensive	intensive	JJ
cord-275730-650sjwyy	22	3	research	research	NN
cord-275730-650sjwyy	22	4	on	on	IN
cord-275730-650sjwyy	22	5	new	new	JJ
cord-275730-650sjwyy	22	6	vaccine	vaccine	NN
cord-275730-650sjwyy	22	7	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	22	8	,	,	,
cord-275730-650sjwyy	22	9	very	very	RB
cord-275730-650sjwyy	22	10	few	few	JJ
cord-275730-650sjwyy	22	11	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	22	12	have	have	VBP
cord-275730-650sjwyy	22	13	been	be	VBN
cord-275730-650sjwyy	22	14	licensed	license	VBN
cord-275730-650sjwyy	22	15	for	for	IN
cord-275730-650sjwyy	22	16	commercial	commercial	JJ
cord-275730-650sjwyy	22	17	use	use	NN
cord-275730-650sjwyy	22	18	today	today	NN
cord-275730-650sjwyy	23	1	(	(	-LRB-
cord-275730-650sjwyy	23	2	Table	table	NN
cord-275730-650sjwyy	23	3	1	1	CD
cord-275730-650sjwyy	23	4	)	)	-RRB-
cord-275730-650sjwyy	23	5	.	.	.
cord-275730-650sjwyy	24	1	Furthermore	furthermore	RB
cord-275730-650sjwyy	24	2	,	,	,
cord-275730-650sjwyy	24	3	along	along	IN
cord-275730-650sjwyy	24	4	with	with	IN
cord-275730-650sjwyy	24	5	the	the	DT
cord-275730-650sjwyy	24	6	new	new	JJ
cord-275730-650sjwyy	24	7	vaccine	vaccine	NN
cord-275730-650sjwyy	24	8	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	24	9	such	such	JJ
cord-275730-650sjwyy	24	10	as	as	IN
cord-275730-650sjwyy	24	11	MF59	MF59	NNP
cord-275730-650sjwyy	24	12	,	,	,
cord-275730-650sjwyy	24	13	AS03	AS03	NNP
cord-275730-650sjwyy	24	14	,	,	,
cord-275730-650sjwyy	24	15	and	and	CC
cord-275730-650sjwyy	24	16	AS04	AS04	NNP
cord-275730-650sjwyy	24	17	,	,	,
cord-275730-650sjwyy	24	18	the	the	DT
cord-275730-650sjwyy	24	19	development	development	NN
cord-275730-650sjwyy	24	20	of	of	IN
cord-275730-650sjwyy	24	21	new	new	JJ
cord-275730-650sjwyy	24	22	safe	safe	JJ
cord-275730-650sjwyy	24	23	,	,	,
cord-275730-650sjwyy	24	24	potent	potent	JJ
cord-275730-650sjwyy	24	25	vaccine	vaccine	NN
cord-275730-650sjwyy	24	26	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	24	27	that	that	WDT
cord-275730-650sjwyy	24	28	generates	generate	VBZ
cord-275730-650sjwyy	24	29	long	long	RB
cord-275730-650sjwyy	24	30	-	-	HYPH
cord-275730-650sjwyy	24	31	lasting	last	VBG
cord-275730-650sjwyy	24	32	and	and	CC
cord-275730-650sjwyy	24	33	balanced	balanced	JJ
cord-275730-650sjwyy	24	34	vaccine	vaccine	NN
cord-275730-650sjwyy	24	35	responses	response	NNS
cord-275730-650sjwyy	24	36	for	for	IN
cord-275730-650sjwyy	24	37	intracellular	intracellular	JJ
cord-275730-650sjwyy	24	38	and	and	CC
cord-275730-650sjwyy	24	39	extracellular	extracellular	JJ
cord-275730-650sjwyy	24	40	pathogens	pathogen	NNS
cord-275730-650sjwyy	24	41	is	be	VBZ
cord-275730-650sjwyy	24	42	a	a	DT
cord-275730-650sjwyy	24	43	high	high	JJ
cord-275730-650sjwyy	24	44	priority	priority	NN
cord-275730-650sjwyy	24	45	for	for	IN
cord-275730-650sjwyy	24	46	public	public	JJ
cord-275730-650sjwyy	24	47	health	health	NN
cord-275730-650sjwyy	24	48	.	.	.
cord-275730-650sjwyy	25	1	Cancer	cancer	NN
cord-275730-650sjwyy	25	2	-	-	HYPH
cord-275730-650sjwyy	25	3	related	relate	VBN
cord-275730-650sjwyy	25	4	death	death	NN
cord-275730-650sjwyy	25	5	is	be	VBZ
cord-275730-650sjwyy	25	6	the	the	DT
cord-275730-650sjwyy	25	7	second	second	JJ
cord-275730-650sjwyy	25	8	leading	leading	JJ
cord-275730-650sjwyy	25	9	cause	cause	NN
cord-275730-650sjwyy	25	10	of	of	IN
cord-275730-650sjwyy	25	11	death	death	NN
cord-275730-650sjwyy	25	12	.	.	.
cord-275730-650sjwyy	26	1	The	the	DT
cord-275730-650sjwyy	26	2	current	current	JJ
cord-275730-650sjwyy	26	3	regimen	regimen	NN
cord-275730-650sjwyy	26	4	of	of	IN
cord-275730-650sjwyy	26	5	cancer	cancer	NN
cord-275730-650sjwyy	26	6	therapies	therapy	NNS
cord-275730-650sjwyy	26	7	are	be	VBP
cord-275730-650sjwyy	26	8	effective	effective	JJ
cord-275730-650sjwyy	26	9	in	in	IN
cord-275730-650sjwyy	26	10	extending	extend	VBG
cord-275730-650sjwyy	26	11	the	the	DT
cord-275730-650sjwyy	26	12	patients	patient	NNS
cord-275730-650sjwyy	26	13	'	'	POS
cord-275730-650sjwyy	26	14	life	life	NN
cord-275730-650sjwyy	26	15	but	but	CC
cord-275730-650sjwyy	26	16	generally	generally	RB
cord-275730-650sjwyy	26	17	fail	fail	VBP
cord-275730-650sjwyy	26	18	to	to	TO
cord-275730-650sjwyy	26	19	prevent	prevent	VB
cord-275730-650sjwyy	26	20	relapse	relapse	NN
cord-275730-650sjwyy	26	21	and	and	CC
cord-275730-650sjwyy	26	22	death	death	NN
cord-275730-650sjwyy	26	23	.	.	.
cord-275730-650sjwyy	27	1	Immunotherapy	Immunotherapy	NNP
cord-275730-650sjwyy	27	2	,	,	,
cord-275730-650sjwyy	27	3	by	by	IN
cord-275730-650sjwyy	27	4	activating	activate	VBG
cord-275730-650sjwyy	27	5	the	the	DT
cord-275730-650sjwyy	27	6	immune	immune	JJ
cord-275730-650sjwyy	27	7	responses	response	NNS
cord-275730-650sjwyy	27	8	and	and	CC
cord-275730-650sjwyy	27	9	generating	generate	VBG
cord-275730-650sjwyy	27	10	memory	memory	NN
cord-275730-650sjwyy	27	11	cytotoxic	cytotoxic	JJ
cord-275730-650sjwyy	27	12	CD8	CD8	NNP
cord-275730-650sjwyy	27	13	+	+	CC
cord-275730-650sjwyy	27	14	T	T	NNP
cord-275730-650sjwyy	27	15	cells	cell	NNS
cord-275730-650sjwyy	27	16	,	,	,
cord-275730-650sjwyy	27	17	can	can	MD
cord-275730-650sjwyy	27	18	potentially	potentially	RB
cord-275730-650sjwyy	27	19	prevent	prevent	VB
cord-275730-650sjwyy	27	20	tumor	tumor	NN
cord-275730-650sjwyy	27	21	metastasis	metastasis	NN
cord-275730-650sjwyy	27	22	,	,	,
cord-275730-650sjwyy	27	23	regression	regression	NN
cord-275730-650sjwyy	27	24	,	,	,
cord-275730-650sjwyy	27	25	and	and	CC
cord-275730-650sjwyy	27	26	cure	cure	NN
cord-275730-650sjwyy	27	27	cancer	cancer	NN
cord-275730-650sjwyy	27	28	.	.	.
cord-275730-650sjwyy	28	1	Cancer	cancer	NN
cord-275730-650sjwyy	28	2	development	development	NN
cord-275730-650sjwyy	28	3	is	be	VBZ
cord-275730-650sjwyy	28	4	accompanied	accompany	VBN
cord-275730-650sjwyy	28	5	by	by	IN
cord-275730-650sjwyy	28	6	an	an	DT
cord-275730-650sjwyy	28	7	immunosuppressive	immunosuppressive	JJ
cord-275730-650sjwyy	28	8	microenvironment	microenvironment	NN
cord-275730-650sjwyy	28	9	and	and	CC
cord-275730-650sjwyy	28	10	T	t	NN
cord-275730-650sjwyy	28	11	cell	cell	NN
cord-275730-650sjwyy	28	12	dysfunction	dysfunction	NN
cord-275730-650sjwyy	28	13	and	and	CC
cord-275730-650sjwyy	28	14	exhaustion	exhaustion	NN
cord-275730-650sjwyy	28	15	[	[	-LRB-
cord-275730-650sjwyy	28	16	24	24	CD
cord-275730-650sjwyy	28	17	]	]	-RRB-
cord-275730-650sjwyy	28	18	[	[	-LRB-
cord-275730-650sjwyy	28	19	25	25	CD
cord-275730-650sjwyy	28	20	]	]	-RRB-
cord-275730-650sjwyy	28	21	[	[	-LRB-
cord-275730-650sjwyy	28	22	26	26	CD
cord-275730-650sjwyy	28	23	]	]	-RRB-
cord-275730-650sjwyy	28	24	.	.	.
cord-275730-650sjwyy	29	1	Methods	method	NNS
cord-275730-650sjwyy	29	2	to	to	TO
cord-275730-650sjwyy	29	3	break	break	VB
cord-275730-650sjwyy	29	4	tumor	tumor	NN
cord-275730-650sjwyy	29	5	tolerance	tolerance	NN
cord-275730-650sjwyy	29	6	and	and	CC
cord-275730-650sjwyy	29	7	activate	activate	VB
cord-275730-650sjwyy	29	8	anti	anti	JJ
cord-275730-650sjwyy	29	9	-	-	JJ
cord-275730-650sjwyy	29	10	tumor	tumor	JJ
cord-275730-650sjwyy	29	11	immunity	immunity	NN
cord-275730-650sjwyy	29	12	are	be	VBP
cord-275730-650sjwyy	29	13	highly	highly	RB
cord-275730-650sjwyy	29	14	desirable	desirable	JJ
cord-275730-650sjwyy	29	15	.	.	.
cord-275730-650sjwyy	30	1	CDNs	CDNs	NNP
cord-275730-650sjwyy	30	2	have	have	VBP
cord-275730-650sjwyy	30	3	a	a	DT
cord-275730-650sjwyy	30	4	potent	potent	JJ
cord-275730-650sjwyy	30	5	anti	anti	JJ
cord-275730-650sjwyy	30	6	-	-	JJ
cord-275730-650sjwyy	30	7	tumor	tumor	JJ
cord-275730-650sjwyy	30	8	activity	activity	NN
cord-275730-650sjwyy	30	9	.	.	.
cord-275730-650sjwyy	31	1	Demaria	Demaria	NNP
cord-275730-650sjwyy	31	2	et	et	NNP
cord-275730-650sjwyy	31	3	al	al	NNP
cord-275730-650sjwyy	31	4	.	.	.
cord-275730-650sjwyy	32	1	showed	show	VBD
cord-275730-650sjwyy	32	2	that	that	IN
cord-275730-650sjwyy	32	3	intratumoral	intratumoral	JJ
cord-275730-650sjwyy	32	4	injection	injection	NN
cord-275730-650sjwyy	32	5	of	of	IN
cord-275730-650sjwyy	32	6	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	32	7	enhanced	enhance	VBD
cord-275730-650sjwyy	32	8	the	the	DT
cord-275730-650sjwyy	32	9	anti	anti	JJ
cord-275730-650sjwyy	32	10	-	-	JJ
cord-275730-650sjwyy	32	11	tumor	tumor	JJ
cord-275730-650sjwyy	32	12	CD8	CD8	NNP
cord-275730-650sjwyy	32	13	+	+	CC
cord-275730-650sjwyy	32	14	T	T	NNP
cord-275730-650sjwyy	32	15	cell	cell	NN
cord-275730-650sjwyy	32	16	response	response	NN
cord-275730-650sjwyy	32	17	inhibiting	inhibit	VBG
cord-275730-650sjwyy	32	18	the	the	DT
cord-275730-650sjwyy	32	19	growth	growth	NN
cord-275730-650sjwyy	32	20	of	of	IN
cord-275730-650sjwyy	32	21	injected	inject	VBN
cord-275730-650sjwyy	32	22	tumors	tumor	NNS
cord-275730-650sjwyy	32	23	in	in	IN
cord-275730-650sjwyy	32	24	mice	mice	NN
cord-275730-650sjwyy	32	25	models	model	NNS
cord-275730-650sjwyy	32	26	of	of	IN
cord-275730-650sjwyy	32	27	melanoma	melanoma	NN
cord-275730-650sjwyy	32	28	and	and	CC
cord-275730-650sjwyy	32	29	colon	colon	NN
cord-275730-650sjwyy	32	30	cancer	cancer	NN
cord-275730-650sjwyy	32	31	[	[	-LRB-
cord-275730-650sjwyy	32	32	27	27	CD
cord-275730-650sjwyy	32	33	]	]	-RRB-
cord-275730-650sjwyy	32	34	.	.	.
cord-275730-650sjwyy	33	1	Intratumoral	intratumoral	JJ
cord-275730-650sjwyy	33	2	injection	injection	NN
cord-275730-650sjwyy	33	3	of	of	IN
cord-275730-650sjwyy	33	4	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	33	5	in	in	IN
cord-275730-650sjwyy	33	6	B16F10	b16f10	JJ
cord-275730-650sjwyy	33	7	lung	lung	NN
cord-275730-650sjwyy	33	8	metastasis	metastasis	NN
cord-275730-650sjwyy	33	9	induced	induce	VBD
cord-275730-650sjwyy	33	10	a	a	DT
cord-275730-650sjwyy	33	11	systemic	systemic	JJ
cord-275730-650sjwyy	33	12	CD8	CD8	NNS
cord-275730-650sjwyy	33	13	+	+	CC
cord-275730-650sjwyy	33	14	T	T	NNP
cord-275730-650sjwyy	33	15	cell	cell	NN
cord-275730-650sjwyy	33	16	response	response	NN
cord-275730-650sjwyy	33	17	to	to	TO
cord-275730-650sjwyy	33	18	restrict	restrict	VB
cord-275730-650sjwyy	33	19	the	the	DT
cord-275730-650sjwyy	33	20	growth	growth	NN
cord-275730-650sjwyy	33	21	of	of	IN
cord-275730-650sjwyy	33	22	distant	distant	JJ
cord-275730-650sjwyy	33	23	tumors	tumor	NNS
cord-275730-650sjwyy	33	24	[	[	-LRB-
cord-275730-650sjwyy	33	25	28	28	CD
cord-275730-650sjwyy	33	26	]	]	-RRB-
cord-275730-650sjwyy	33	27	.	.	.
cord-275730-650sjwyy	34	1	Nicolai	Nicolai	NNP
cord-275730-650sjwyy	34	2	et	et	NNP
cord-275730-650sjwyy	34	3	al	al	NNP
cord-275730-650sjwyy	34	4	.	.	NNP
cord-275730-650sjwyy	34	5	showed	show	VBD
cord-275730-650sjwyy	34	6	that	that	IN
cord-275730-650sjwyy	34	7	the	the	DT
cord-275730-650sjwyy	34	8	CDA	CDA	NNP
cord-275730-650sjwyy	34	9	activated	activate	VBD
cord-275730-650sjwyy	34	10	natural	natural	JJ
cord-275730-650sjwyy	34	11	killer	killer	NN
cord-275730-650sjwyy	34	12	(	(	-LRB-
cord-275730-650sjwyy	34	13	NK	NK	NNP
cord-275730-650sjwyy	34	14	)	)	-RRB-
cord-275730-650sjwyy	34	15	cells	cell	NNS
cord-275730-650sjwyy	34	16	-	-	:
cord-275730-650sjwyy	34	17	dependent	dependent	JJ
cord-275730-650sjwyy	34	18	and	and	CC
cord-275730-650sjwyy	34	19	CD8	CD8	NNP
cord-275730-650sjwyy	34	20	+	+	CC
cord-275730-650sjwyy	34	21	T	T	NNP
cord-275730-650sjwyy	34	22	cell	cell	NN
cord-275730-650sjwyy	34	23	-	-	HYPH
cord-275730-650sjwyy	34	24	independent	independent	JJ
cord-275730-650sjwyy	34	25	mechanism	mechanism	NN
cord-275730-650sjwyy	34	26	for	for	IN
cord-275730-650sjwyy	34	27	tumor	tumor	NN
cord-275730-650sjwyy	34	28	rejection	rejection	NN
cord-275730-650sjwyy	34	29	originated	originate	VBD
cord-275730-650sjwyy	34	30	from	from	IN
cord-275730-650sjwyy	34	31	different	different	JJ
cord-275730-650sjwyy	34	32	tissue	tissue	NN
cord-275730-650sjwyy	34	33	types	type	NNS
cord-275730-650sjwyy	34	34	[	[	-LRB-
cord-275730-650sjwyy	34	35	29	29	CD
cord-275730-650sjwyy	34	36	]	]	-RRB-
cord-275730-650sjwyy	34	37	.	.	.
cord-275730-650sjwyy	35	1	CDA	CDA	NNP
cord-275730-650sjwyy	35	2	induced	induce	VBN
cord-275730-650sjwyy	35	3	tumor	tumor	NN
cord-275730-650sjwyy	35	4	regression	regression	NN
cord-275730-650sjwyy	35	5	even	even	RB
cord-275730-650sjwyy	35	6	in	in	IN
cord-275730-650sjwyy	35	7	Rag2	Rag2	NNP
cord-275730-650sjwyy	36	1	-/mice	-/mice	.
cord-275730-650sjwyy	37	1	but	but	CC
cord-275730-650sjwyy	37	2	was	be	VBD
cord-275730-650sjwyy	37	3	strongly	strongly	RB
cord-275730-650sjwyy	37	4	depleted	deplete	VBN
cord-275730-650sjwyy	37	5	in	in	IN
cord-275730-650sjwyy	37	6	Rag2	Rag2	NNP
cord-275730-650sjwyy	37	7	-/-Il2rg	-/-il2rg	CD
cord-275730-650sjwyy	38	1	-/mice	-/mice	.
cord-275730-650sjwyy	39	1	lacking	lack	VBG
cord-275730-650sjwyy	39	2	NK	NK	NNP
cord-275730-650sjwyy	39	3	cells	cell	NNS
cord-275730-650sjwyy	39	4	,	,	,
cord-275730-650sjwyy	39	5	B	b	NN
cord-275730-650sjwyy	39	6	,	,	,
cord-275730-650sjwyy	39	7	and	and	CC
cord-275730-650sjwyy	39	8	T	t	NN
cord-275730-650sjwyy	39	9	cells	cell	NNS
cord-275730-650sjwyy	39	10	[	[	-LRB-
cord-275730-650sjwyy	39	11	29	29	CD
cord-275730-650sjwyy	39	12	]	]	-RRB-
cord-275730-650sjwyy	39	13	.	.	.
cord-275730-650sjwyy	40	1	Moreover	moreover	RB
cord-275730-650sjwyy	40	2	,	,	,
cord-275730-650sjwyy	40	3	suppressing	suppress	VBG
cord-275730-650sjwyy	40	4	the	the	DT
cord-275730-650sjwyy	40	5	NK	NK	NNP
cord-275730-650sjwyy	40	6	cell	cell	NN
cord-275730-650sjwyy	40	7	activity	activity	NN
cord-275730-650sjwyy	40	8	by	by	IN
cord-275730-650sjwyy	40	9	NK1.1	NK1.1	NNP
cord-275730-650sjwyy	40	10	antibody	antibody	NN
cord-275730-650sjwyy	40	11	resulted	result	VBD
cord-275730-650sjwyy	40	12	in	in	IN
cord-275730-650sjwyy	40	13	rapid	rapid	JJ
cord-275730-650sjwyy	40	14	tumor	tumor	NN
cord-275730-650sjwyy	40	15	growth	growth	NN
cord-275730-650sjwyy	40	16	of	of	IN
cord-275730-650sjwyy	40	17	MC-38-B2m-/-(colorectal	MC-38-B2m-/-(colorectal	NNP
cord-275730-650sjwyy	40	18	)	)	-RRB-
cord-275730-650sjwyy	40	19	,	,	,
cord-275730-650sjwyy	40	20	B16-F10-B2m-/-(melanoma	B16-F10-B2m-/-(melanoma	NNP
cord-275730-650sjwyy	40	21	)	)	-RRB-
cord-275730-650sjwyy	40	22	,	,	,
cord-275730-650sjwyy	40	23	CT26-B2m-/-(colorectal	CT26-B2m-/-(colorectal	NNP
cord-275730-650sjwyy	40	24	)	)	-RRB-
cord-275730-650sjwyy	40	25	,	,	,
cord-275730-650sjwyy	40	26	C1498-B2m-/-(leukemic	C1498-B2m-/-(leukemic	NNP
cord-275730-650sjwyy	40	27	)	)	-RRB-
cord-275730-650sjwyy	40	28	,	,	,
cord-275730-650sjwyy	40	29	and	and	CC
cord-275730-650sjwyy	40	30	RMA	RMA	NNP
cord-275730-650sjwyy	40	31	-	-	HYPH
cord-275730-650sjwyy	40	32	B2m-/-(lymphoma	B2m-/-(lymphoma	NNP
cord-275730-650sjwyy	40	33	)	)	-RRB-
cord-275730-650sjwyy	40	34	tumour	tumour	NN
cord-275730-650sjwyy	40	35	models	model	NNS
cord-275730-650sjwyy	40	36	[	[	-LRB-
cord-275730-650sjwyy	40	37	29	29	CD
cord-275730-650sjwyy	40	38	]	]	-RRB-
cord-275730-650sjwyy	40	39	.	.	.
cord-275730-650sjwyy	41	1	The	the	DT
cord-275730-650sjwyy	41	2	study	study	NN
cord-275730-650sjwyy	41	3	was	be	VBD
cord-275730-650sjwyy	41	4	clinically	clinically	RB
cord-275730-650sjwyy	41	5	relevant	relevant	JJ
cord-275730-650sjwyy	41	6	as	as	IN
cord-275730-650sjwyy	41	7	human	human	JJ
cord-275730-650sjwyy	41	8	tumors	tumor	NNS
cord-275730-650sjwyy	41	9	such	such	JJ
cord-275730-650sjwyy	41	10	as	as	IN
cord-275730-650sjwyy	41	11	Hodgkin	Hodgkin	NNP
cord-275730-650sjwyy	41	12	's	's	POS
cord-275730-650sjwyy	41	13	lymphoma	lymphoma	NN
cord-275730-650sjwyy	41	14	often	often	RB
cord-275730-650sjwyy	41	15	exhibit	exhibit	VBP
cord-275730-650sjwyy	41	16	a	a	DT
cord-275730-650sjwyy	41	17	partial	partial	JJ
cord-275730-650sjwyy	41	18	loss	loss	NN
cord-275730-650sjwyy	41	19	of	of	IN
cord-275730-650sjwyy	41	20	MHC	MHC	NNP
cord-275730-650sjwyy	41	21	I	-PRON-	PRP
cord-275730-650sjwyy	41	22	thereby	thereby	RB
cord-275730-650sjwyy	41	23	unable	unable	JJ
cord-275730-650sjwyy	41	24	to	to	TO
cord-275730-650sjwyy	41	25	activate	activate	VB
cord-275730-650sjwyy	41	26	a	a	DT
cord-275730-650sjwyy	41	27	CTL	CTL	NNP
cord-275730-650sjwyy	41	28	response	response	NN
cord-275730-650sjwyy	41	29	.	.	.
cord-275730-650sjwyy	42	1	Activating	activate	VBG
cord-275730-650sjwyy	42	2	NK	NK	NNP
cord-275730-650sjwyy	42	3	cell	cell	NN
cord-275730-650sjwyy	42	4	-	-	HYPH
cord-275730-650sjwyy	42	5	mediated	mediate	VBN
cord-275730-650sjwyy	42	6	anti	anti	JJ
cord-275730-650sjwyy	42	7	-	-	JJ
cord-275730-650sjwyy	42	8	tumor	tumor	JJ
cord-275730-650sjwyy	42	9	immunity	immunity	NN
cord-275730-650sjwyy	42	10	then	then	RB
cord-275730-650sjwyy	42	11	becomes	become	VBZ
cord-275730-650sjwyy	42	12	essential	essential	JJ
cord-275730-650sjwyy	42	13	.	.	.
cord-275730-650sjwyy	43	1	A	a	DT
cord-275730-650sjwyy	43	2	major	major	JJ
cord-275730-650sjwyy	43	3	hurdle	hurdle	NN
cord-275730-650sjwyy	43	4	in	in	IN
cord-275730-650sjwyy	43	5	cancer	cancer	NN
cord-275730-650sjwyy	43	6	immunotherapy	immunotherapy	NN
cord-275730-650sjwyy	43	7	is	be	VBZ
cord-275730-650sjwyy	43	8	the	the	DT
cord-275730-650sjwyy	43	9	"	"	``
cord-275730-650sjwyy	43	10	cold	cold	JJ
cord-275730-650sjwyy	43	11	"	"	''
cord-275730-650sjwyy	43	12	tumors	tumor	NNS
cord-275730-650sjwyy	43	13	,	,	,
cord-275730-650sjwyy	43	14	which	which	WDT
cord-275730-650sjwyy	43	15	lack	lack	VBP
cord-275730-650sjwyy	43	16	inherent	inherent	JJ
cord-275730-650sjwyy	43	17	immunogenicity	immunogenicity	NN
cord-275730-650sjwyy	43	18	reflecting	reflect	VBG
cord-275730-650sjwyy	43	19	in	in	IN
cord-275730-650sjwyy	43	20	the	the	DT
cord-275730-650sjwyy	43	21	inability	inability	NN
cord-275730-650sjwyy	43	22	of	of	IN
cord-275730-650sjwyy	43	23	checkpoint	checkpoint	NN
cord-275730-650sjwyy	43	24	inhibitors	inhibitor	NNS
cord-275730-650sjwyy	43	25	to	to	TO
cord-275730-650sjwyy	43	26	attenuate	attenuate	VB
cord-275730-650sjwyy	43	27	tumor	tumor	NN
cord-275730-650sjwyy	43	28	growth	growth	NN
cord-275730-650sjwyy	43	29	.	.	.
cord-275730-650sjwyy	44	1	A	a	DT
cord-275730-650sjwyy	44	2	study	study	NN
cord-275730-650sjwyy	44	3	by	by	IN
cord-275730-650sjwyy	44	4	Francica	Francica	NNP
cord-275730-650sjwyy	44	5	et	et	NNP
cord-275730-650sjwyy	44	6	al	al	NNP
cord-275730-650sjwyy	44	7	.	.	NNP
cord-275730-650sjwyy	44	8	showed	show	VBD
cord-275730-650sjwyy	44	9	that	that	IN
cord-275730-650sjwyy	44	10	the	the	DT
cord-275730-650sjwyy	44	11	CDN	CDN	NNP
cord-275730-650sjwyy	44	12	mediated	mediate	VBN
cord-275730-650sjwyy	44	13	tumor	tumor	NN
cord-275730-650sjwyy	44	14	necrosis	necrosis	NN
cord-275730-650sjwyy	44	15	factor	factor	NN
cord-275730-650sjwyy	44	16	(	(	-LRB-
cord-275730-650sjwyy	44	17	TNF)-α	tnf)-α	NN
cord-275730-650sjwyy	44	18	production	production	NN
cord-275730-650sjwyy	44	19	by	by	IN
cord-275730-650sjwyy	44	20	innate	innate	JJ
cord-275730-650sjwyy	44	21	immune	immune	JJ
cord-275730-650sjwyy	44	22	cells	cell	NNS
cord-275730-650sjwyy	44	23	are	be	VBP
cord-275730-650sjwyy	44	24	responsible	responsible	JJ
cord-275730-650sjwyy	44	25	for	for	IN
cord-275730-650sjwyy	44	26	acute	acute	JJ
cord-275730-650sjwyy	44	27	tumor	tumor	NN
cord-275730-650sjwyy	44	28	clearance	clearance	NN
cord-275730-650sjwyy	44	29	,	,	,
cord-275730-650sjwyy	44	30	and	and	CC
cord-275730-650sjwyy	44	31	blocking	block	VBG
cord-275730-650sjwyy	44	32	TNF	TNF	NNP
cord-275730-650sjwyy	44	33	-	-	HYPH
cord-275730-650sjwyy	44	34	α	α	NNP
cord-275730-650sjwyy	44	35	inhibits	inhibit	VBZ
cord-275730-650sjwyy	44	36	tumor	tumor	NN
cord-275730-650sjwyy	44	37	necrosis	necrosis	NN
cord-275730-650sjwyy	44	38	and	and	CC
cord-275730-650sjwyy	44	39	clearance	clearance	NN
cord-275730-650sjwyy	44	40	against	against	IN
cord-275730-650sjwyy	44	41	"	"	``
cord-275730-650sjwyy	44	42	cold	cold	JJ
cord-275730-650sjwyy	44	43	"	"	''
cord-275730-650sjwyy	44	44	tumors	tumor	NNS
cord-275730-650sjwyy	44	45	[	[	-LRB-
cord-275730-650sjwyy	44	46	30	30	CD
cord-275730-650sjwyy	44	47	]	]	-RRB-
cord-275730-650sjwyy	44	48	.	.	.
cord-275730-650sjwyy	45	1	Lastly	lastly	RB
cord-275730-650sjwyy	45	2	,	,	,
cord-275730-650sjwyy	45	3	CDNs	cdn	VBZ
cord-275730-650sjwyy	45	4	effectively	effectively	RB
cord-275730-650sjwyy	45	5	induce	induce	VBP
cord-275730-650sjwyy	45	6	DC	DC	NNP
cord-275730-650sjwyy	45	7	cross	cross	NN
cord-275730-650sjwyy	45	8	-	-	NN
cord-275730-650sjwyy	45	9	presentation	presentation	NN
cord-275730-650sjwyy	45	10	to	to	IN
cord-275730-650sjwyy	45	11	the	the	DT
cord-275730-650sjwyy	45	12	MHC	MHC	NNP
cord-275730-650sjwyy	45	13	class	class	NN
cord-275730-650sjwyy	45	14	I	-PRON-	PRP
cord-275730-650sjwyy	45	15	molecules	molecule	VBZ
cord-275730-650sjwyy	45	16	to	to	TO
cord-275730-650sjwyy	45	17	produce	produce	VB
cord-275730-650sjwyy	45	18	a	a	DT
cord-275730-650sjwyy	45	19	CTL	ctl	NN
cord-275730-650sjwyy	45	20	response	response	NN
cord-275730-650sjwyy	45	21	[	[	-LRB-
cord-275730-650sjwyy	45	22	18	18	CD
cord-275730-650sjwyy	45	23	]	]	-RRB-
cord-275730-650sjwyy	45	24	.	.	.
cord-275730-650sjwyy	46	1	A	a	DT
cord-275730-650sjwyy	46	2	potent	potent	JJ
cord-275730-650sjwyy	46	3	antigen	antigen	NN
cord-275730-650sjwyy	46	4	-	-	HYPH
cord-275730-650sjwyy	46	5	specific	specific	JJ
cord-275730-650sjwyy	46	6	CD8	CD8	NNP
cord-275730-650sjwyy	46	7	+	+	CC
cord-275730-650sjwyy	46	8	memory	memory	NN
cord-275730-650sjwyy	46	9	T	T	NNP
cord-275730-650sjwyy	46	10	cell	cell	NN
cord-275730-650sjwyy	46	11	response	response	NN
cord-275730-650sjwyy	46	12	by	by	IN
cord-275730-650sjwyy	46	13	in	in	IN
cord-275730-650sjwyy	46	14	vivo	vivo	NN
cord-275730-650sjwyy	46	15	targeting	target	VBG
cord-275730-650sjwyy	46	16	of	of	IN
cord-275730-650sjwyy	46	17	the	the	DT
cord-275730-650sjwyy	46	18	DEC-205	DEC-205	NNP
cord-275730-650sjwyy	46	19	receptor	receptor	NN
cord-275730-650sjwyy	46	20	in	in	IN
cord-275730-650sjwyy	46	21	DC	DC	NNP
cord-275730-650sjwyy	46	22	,	,	,
cord-275730-650sjwyy	46	23	thereby	thereby	RB
cord-275730-650sjwyy	46	24	provided	provide	VBD
cord-275730-650sjwyy	46	25	an	an	DT
cord-275730-650sjwyy	46	26	effective	effective	JJ
cord-275730-650sjwyy	46	27	approach	approach	NN
cord-275730-650sjwyy	46	28	to	to	TO
cord-275730-650sjwyy	46	29	target	target	VB
cord-275730-650sjwyy	46	30	viral	viral	JJ
cord-275730-650sjwyy	46	31	infections	infection	NNS
cord-275730-650sjwyy	46	32	[	[	-LRB-
cord-275730-650sjwyy	46	33	18	18	CD
cord-275730-650sjwyy	46	34	]	]	-RRB-
cord-275730-650sjwyy	46	35	.	.	.
cord-275730-650sjwyy	47	1	Combinatorial	combinatorial	JJ
cord-275730-650sjwyy	47	2	methods	method	NNS
cord-275730-650sjwyy	47	3	such	such	JJ
cord-275730-650sjwyy	47	4	as	as	IN
cord-275730-650sjwyy	47	5	intramuscular	intramuscular	JJ
cord-275730-650sjwyy	47	6	immunization	immunization	NN
cord-275730-650sjwyy	47	7	of	of	IN
cord-275730-650sjwyy	47	8	CDA	CDA	NNP
cord-275730-650sjwyy	47	9	with	with	IN
cord-275730-650sjwyy	47	10	alum	alum	NN
cord-275730-650sjwyy	47	11	have	have	VBP
cord-275730-650sjwyy	47	12	shown	show	VBN
cord-275730-650sjwyy	47	13	significant	significant	JJ
cord-275730-650sjwyy	47	14	enhancement	enhancement	NN
cord-275730-650sjwyy	47	15	in	in	IN
cord-275730-650sjwyy	47	16	antigen	antigen	NN
cord-275730-650sjwyy	47	17	-	-	HYPH
cord-275730-650sjwyy	47	18	specific	specific	JJ
cord-275730-650sjwyy	47	19	CD4	CD4	NNP
cord-275730-650sjwyy	47	20	+	+	CC
cord-275730-650sjwyy	47	21	and	and	CC
cord-275730-650sjwyy	47	22	CD8	CD8	NNP
cord-275730-650sjwyy	47	23	+	+	CC
cord-275730-650sjwyy	47	24	T	T	NNP
cord-275730-650sjwyy	47	25	cell	cell	NN
cord-275730-650sjwyy	47	26	responses	response	NNS
cord-275730-650sjwyy	47	27	while	while	IN
cord-275730-650sjwyy	47	28	maintaining	maintain	VBG
cord-275730-650sjwyy	47	29	a	a	DT
cord-275730-650sjwyy	47	30	safety	safety	NN
cord-275730-650sjwyy	47	31	profile	profile	NN
cord-275730-650sjwyy	47	32	[	[	-LRB-
cord-275730-650sjwyy	47	33	31	31	CD
cord-275730-650sjwyy	47	34	]	]	-RRB-
cord-275730-650sjwyy	47	35	.	.	.
cord-275730-650sjwyy	48	1	The	the	DT
cord-275730-650sjwyy	48	2	mucosal	mucosal	JJ
cord-275730-650sjwyy	48	3	surface	surface	NN
cord-275730-650sjwyy	48	4	is	be	VBZ
cord-275730-650sjwyy	48	5	a	a	DT
cord-275730-650sjwyy	48	6	natural	natural	JJ
cord-275730-650sjwyy	48	7	point	point	NN
cord-275730-650sjwyy	48	8	of	of	IN
cord-275730-650sjwyy	48	9	entry	entry	NN
cord-275730-650sjwyy	48	10	for	for	IN
cord-275730-650sjwyy	48	11	many	many	JJ
cord-275730-650sjwyy	48	12	respiratory	respiratory	JJ
cord-275730-650sjwyy	48	13	pathogens	pathogen	NNS
cord-275730-650sjwyy	48	14	such	such	JJ
cord-275730-650sjwyy	48	15	as	as	IN
cord-275730-650sjwyy	48	16	influenza	influenza	NN
cord-275730-650sjwyy	48	17	,	,	,
cord-275730-650sjwyy	48	18	Streptococcus	streptococcus	NN
cord-275730-650sjwyy	48	19	pneumoniae	pneumoniae	NN
cord-275730-650sjwyy	48	20	,	,	,
cord-275730-650sjwyy	48	21	Mycobacterium	Mycobacterium	NNP
cord-275730-650sjwyy	48	22	tuberculosis	tuberculosis	NN
cord-275730-650sjwyy	48	23	,	,	,
cord-275730-650sjwyy	48	24	Staphylococcus	Staphylococcus	NNP
cord-275730-650sjwyy	48	25	aureus	aureus	NN
cord-275730-650sjwyy	48	26	,	,	,
cord-275730-650sjwyy	48	27	B.	B.	NNP
cord-275730-650sjwyy	48	28	anthracis	anthracis	NN
cord-275730-650sjwyy	48	29	,	,	,
cord-275730-650sjwyy	48	30	coronavirus	coronavirus	NN
cord-275730-650sjwyy	48	31	,	,	,
cord-275730-650sjwyy	48	32	rotavirus	rotavirus	NN
cord-275730-650sjwyy	48	33	,	,	,
cord-275730-650sjwyy	48	34	etc	etc	FW
cord-275730-650sjwyy	48	35	.	.	.
cord-275730-650sjwyy	49	1	Moreover	moreover	RB
cord-275730-650sjwyy	49	2	,	,	,
cord-275730-650sjwyy	49	3	immunization	immunization	NN
cord-275730-650sjwyy	49	4	at	at	IN
cord-275730-650sjwyy	49	5	one	one	CD
cord-275730-650sjwyy	49	6	mucosal	mucosal	NN
cord-275730-650sjwyy	49	7	surface	surface	NN
cord-275730-650sjwyy	49	8	,	,	,
cord-275730-650sjwyy	49	9	particularly	particularly	RB
cord-275730-650sjwyy	49	10	intranasal	intranasal	JJ
cord-275730-650sjwyy	49	11	vaccination	vaccination	NN
cord-275730-650sjwyy	49	12	in	in	IN
cord-275730-650sjwyy	49	13	mice	mouse	NNS
cord-275730-650sjwyy	49	14	,	,	,
cord-275730-650sjwyy	49	15	monkeys	monkey	NNS
cord-275730-650sjwyy	49	16	,	,	,
cord-275730-650sjwyy	49	17	and	and	CC
cord-275730-650sjwyy	49	18	humans	human	NNS
cord-275730-650sjwyy	49	19	has	have	VBZ
cord-275730-650sjwyy	49	20	generated	generate	VBN
cord-275730-650sjwyy	49	21	not	not	RB
cord-275730-650sjwyy	49	22	only	only	RB
cord-275730-650sjwyy	49	23	a	a	DT
cord-275730-650sjwyy	49	24	local	local	JJ
cord-275730-650sjwyy	49	25	IgA	IgA	NNP
cord-275730-650sjwyy	49	26	response	response	NN
cord-275730-650sjwyy	49	27	,	,	,
cord-275730-650sjwyy	49	28	but	but	CC
cord-275730-650sjwyy	49	29	also	also	RB
cord-275730-650sjwyy	49	30	enhanced	enhance	VBD
cord-275730-650sjwyy	49	31	the	the	DT
cord-275730-650sjwyy	49	32	IgA	IgA	NNP
cord-275730-650sjwyy	49	33	response	response	NN
cord-275730-650sjwyy	49	34	in	in	IN
cord-275730-650sjwyy	49	35	salivary	salivary	JJ
cord-275730-650sjwyy	49	36	glands	gland	NNS
cord-275730-650sjwyy	49	37	,	,	,
cord-275730-650sjwyy	49	38	upper	upper	JJ
cord-275730-650sjwyy	49	39	and	and	CC
cord-275730-650sjwyy	49	40	lower	low	JJR
cord-275730-650sjwyy	49	41	respiratory	respiratory	JJ
cord-275730-650sjwyy	49	42	tracts	tract	NNS
cord-275730-650sjwyy	49	43	,	,	,
cord-275730-650sjwyy	49	44	and	and	CC
cord-275730-650sjwyy	49	45	even	even	RB
cord-275730-650sjwyy	49	46	in	in	IN
cord-275730-650sjwyy	49	47	distant	distant	JJ
cord-275730-650sjwyy	49	48	genital	genital	JJ
cord-275730-650sjwyy	49	49	tracts	tract	NNS
cord-275730-650sjwyy	49	50	,	,	,
cord-275730-650sjwyy	49	51	and	and	CC
cord-275730-650sjwyy	49	52	the	the	DT
cord-275730-650sjwyy	49	53	small	small	JJ
cord-275730-650sjwyy	49	54	and	and	CC
cord-275730-650sjwyy	49	55	large	large	JJ
cord-275730-650sjwyy	49	56	intestines	intestine	NNS
cord-275730-650sjwyy	49	57	[	[	-LRB-
cord-275730-650sjwyy	49	58	32	32	CD
cord-275730-650sjwyy	49	59	]	]	-RRB-
cord-275730-650sjwyy	50	1	[	[	-LRB-
cord-275730-650sjwyy	50	2	33	33	CD
cord-275730-650sjwyy	50	3	]	]	-RRB-
cord-275730-650sjwyy	51	1	[	[	-LRB-
cord-275730-650sjwyy	51	2	34	34	CD
cord-275730-650sjwyy	51	3	]	]	-RRB-
cord-275730-650sjwyy	51	4	[	[	-LRB-
cord-275730-650sjwyy	51	5	35	35	CD
cord-275730-650sjwyy	51	6	]	]	-RRB-
cord-275730-650sjwyy	51	7	[	[	-LRB-
cord-275730-650sjwyy	51	8	36	36	CD
cord-275730-650sjwyy	51	9	]	]	-RRB-
cord-275730-650sjwyy	51	10	[	[	-LRB-
cord-275730-650sjwyy	51	11	37	37	CD
cord-275730-650sjwyy	51	12	]	]	-RRB-
cord-275730-650sjwyy	51	13	.	.	.
cord-275730-650sjwyy	52	1	Furthermore	furthermore	RB
cord-275730-650sjwyy	52	2	,	,	,
cord-275730-650sjwyy	52	3	rectal	rectal	JJ
cord-275730-650sjwyy	52	4	immunization	immunization	NN
cord-275730-650sjwyy	52	5	of	of	IN
cord-275730-650sjwyy	52	6	mice	mouse	NNS
cord-275730-650sjwyy	52	7	with	with	IN
cord-275730-650sjwyy	52	8	a	a	DT
cord-275730-650sjwyy	52	9	non	non	JJ
cord-275730-650sjwyy	52	10	-	-	JJ
cord-275730-650sjwyy	52	11	living	living	JJ
cord-275730-650sjwyy	52	12	peptide	peptide	NN
cord-275730-650sjwyy	52	13	-	-	HYPH
cord-275730-650sjwyy	52	14	based	base	VBN
cord-275730-650sjwyy	52	15	vaccine	vaccine	NN
cord-275730-650sjwyy	52	16	effectively	effectively	RB
cord-275730-650sjwyy	52	17	induced	induce	VBD
cord-275730-650sjwyy	52	18	a	a	DT
cord-275730-650sjwyy	52	19	systemic	systemic	JJ
cord-275730-650sjwyy	52	20	CTL	ctl	NN
cord-275730-650sjwyy	52	21	response	response	NN
cord-275730-650sjwyy	52	22	[	[	-LRB-
cord-275730-650sjwyy	52	23	38	38	CD
cord-275730-650sjwyy	52	24	]	]	-RRB-
cord-275730-650sjwyy	52	25	.	.	.
cord-275730-650sjwyy	53	1	Despite	despite	IN
cord-275730-650sjwyy	53	2	its	-PRON-	PRP$
cord-275730-650sjwyy	53	3	role	role	NN
cord-275730-650sjwyy	53	4	in	in	IN
cord-275730-650sjwyy	53	5	providing	provide	VBG
cord-275730-650sjwyy	53	6	a	a	DT
cord-275730-650sjwyy	53	7	frontline	frontline	NN
cord-275730-650sjwyy	53	8	of	of	IN
cord-275730-650sjwyy	53	9	defense	defense	NN
cord-275730-650sjwyy	53	10	,	,	,
cord-275730-650sjwyy	53	11	immunization	immunization	NN
cord-275730-650sjwyy	53	12	via	via	IN
cord-275730-650sjwyy	53	13	the	the	DT
cord-275730-650sjwyy	53	14	mucosal	mucosal	JJ
cord-275730-650sjwyy	53	15	route	route	NN
cord-275730-650sjwyy	53	16	has	have	VBZ
cord-275730-650sjwyy	53	17	not	not	RB
cord-275730-650sjwyy	53	18	been	be	VBN
cord-275730-650sjwyy	53	19	significantly	significantly	RB
cord-275730-650sjwyy	53	20	explored	explore	VBN
cord-275730-650sjwyy	53	21	,	,	,
cord-275730-650sjwyy	53	22	which	which	WDT
cord-275730-650sjwyy	53	23	is	be	VBZ
cord-275730-650sjwyy	53	24	reflected	reflect	VBN
cord-275730-650sjwyy	53	25	by	by	IN
cord-275730-650sjwyy	53	26	the	the	DT
cord-275730-650sjwyy	53	27	limited	limited	JJ
cord-275730-650sjwyy	53	28	number	number	NN
cord-275730-650sjwyy	53	29	of	of	IN
cord-275730-650sjwyy	53	30	available	available	JJ
cord-275730-650sjwyy	53	31	mucosal	mucosal	JJ
cord-275730-650sjwyy	53	32	vaccines	vaccine	NNS
cord-275730-650sjwyy	53	33	against	against	IN
cord-275730-650sjwyy	53	34	influenza	influenza	NN
cord-275730-650sjwyy	53	35	(	(	-LRB-
cord-275730-650sjwyy	53	36	Flumist	Flumist	NNP
cord-275730-650sjwyy	53	37	)	)	-RRB-
cord-275730-650sjwyy	53	38	,	,	,
cord-275730-650sjwyy	53	39	Salmonella	Salmonella	NNP
cord-275730-650sjwyy	53	40	typhi	typhi	NNP
cord-275730-650sjwyy	53	41	(	(	-LRB-
cord-275730-650sjwyy	53	42	Vivotif	Vivotif	NNP
cord-275730-650sjwyy	53	43	)	)	-RRB-
cord-275730-650sjwyy	53	44	,	,	,
cord-275730-650sjwyy	53	45	Rotavirus	Rotavirus	NNP
cord-275730-650sjwyy	53	46	(	(	-LRB-
cord-275730-650sjwyy	53	47	Rotateq	Rotateq	NNP
cord-275730-650sjwyy	53	48	,	,	,
cord-275730-650sjwyy	53	49	Rotatrix	Rotatrix	NNP
cord-275730-650sjwyy	53	50	)	)	-RRB-
cord-275730-650sjwyy	53	51	,	,	,
cord-275730-650sjwyy	53	52	Vibrio	Vibrio	NNP
cord-275730-650sjwyy	53	53	cholerae	cholerae	NN
cord-275730-650sjwyy	53	54	(	(	-LRB-
cord-275730-650sjwyy	53	55	Dukoral	Dukoral	NNP
cord-275730-650sjwyy	53	56	,	,	,
cord-275730-650sjwyy	53	57	Shanchol	Shanchol	NNP
cord-275730-650sjwyy	53	58	)	)	-RRB-
cord-275730-650sjwyy	53	59	,	,	,
cord-275730-650sjwyy	53	60	and	and	CC
cord-275730-650sjwyy	53	61	adeno	adeno	NNP
cord-275730-650sjwyy	53	62	virus	virus	NN
cord-275730-650sjwyy	53	63	[	[	-LRB-
cord-275730-650sjwyy	53	64	39	39	CD
cord-275730-650sjwyy	53	65	]	]	-RRB-
cord-275730-650sjwyy	53	66	.	.	.
cord-275730-650sjwyy	54	1	A	a	DT
cord-275730-650sjwyy	54	2	major	major	JJ
cord-275730-650sjwyy	54	3	obstacle	obstacle	NN
cord-275730-650sjwyy	54	4	in	in	IN
cord-275730-650sjwyy	54	5	the	the	DT
cord-275730-650sjwyy	54	6	development	development	NN
cord-275730-650sjwyy	54	7	of	of	IN
cord-275730-650sjwyy	54	8	a	a	DT
cord-275730-650sjwyy	54	9	mucosal	mucosal	JJ
cord-275730-650sjwyy	54	10	vaccine	vaccine	NN
cord-275730-650sjwyy	54	11	is	be	VBZ
cord-275730-650sjwyy	54	12	the	the	DT
cord-275730-650sjwyy	54	13	availability	availability	NN
cord-275730-650sjwyy	54	14	of	of	IN
cord-275730-650sjwyy	54	15	a	a	DT
cord-275730-650sjwyy	54	16	potent	potent	JJ
cord-275730-650sjwyy	54	17	mucosal	mucosal	NN
cord-275730-650sjwyy	54	18	adjuvant	adjuvant	NN
cord-275730-650sjwyy	54	19	,	,	,
cord-275730-650sjwyy	54	20	which	which	WDT
cord-275730-650sjwyy	54	21	not	not	RB
cord-275730-650sjwyy	54	22	only	only	RB
cord-275730-650sjwyy	54	23	generates	generate	VBZ
cord-275730-650sjwyy	54	24	a	a	DT
cord-275730-650sjwyy	54	25	local	local	JJ
cord-275730-650sjwyy	54	26	mucosal	mucosal	JJ
cord-275730-650sjwyy	54	27	IgA	IgA	NNP
cord-275730-650sjwyy	54	28	response	response	NN
cord-275730-650sjwyy	54	29	but	but	CC
cord-275730-650sjwyy	54	30	also	also	RB
cord-275730-650sjwyy	54	31	enhances	enhance	VBZ
cord-275730-650sjwyy	54	32	mucosal	mucosal	NN
cord-275730-650sjwyy	54	33	Th	Th	NNP
cord-275730-650sjwyy	54	34	and	and	CC
cord-275730-650sjwyy	54	35	CTL	CTL	NNP
cord-275730-650sjwyy	54	36	responses	response	NNS
cord-275730-650sjwyy	54	37	along	along	IN
cord-275730-650sjwyy	54	38	with	with	IN
cord-275730-650sjwyy	54	39	a	a	DT
cord-275730-650sjwyy	54	40	systemic	systemic	JJ
cord-275730-650sjwyy	54	41	reaction	reaction	NN
cord-275730-650sjwyy	54	42	.	.	.
cord-275730-650sjwyy	55	1	The	the	DT
cord-275730-650sjwyy	55	2	most	most	RBS
cord-275730-650sjwyy	55	3	common	common	JJ
cord-275730-650sjwyy	55	4	mucosal	mucosal	NN
cord-275730-650sjwyy	55	5	immunostimulatory	immunostimulatory	NN
cord-275730-650sjwyy	55	6	molecule	molecule	NN
cord-275730-650sjwyy	55	7	used	use	VBN
cord-275730-650sjwyy	55	8	for	for	IN
cord-275730-650sjwyy	55	9	vaccine	vaccine	NN
cord-275730-650sjwyy	55	10	studies	study	NNS
cord-275730-650sjwyy	55	11	are	be	VBP
cord-275730-650sjwyy	55	12	the	the	DT
cord-275730-650sjwyy	55	13	bacterial	bacterial	JJ
cord-275730-650sjwyy	55	14	enterotoxins	enterotoxin	NNS
cord-275730-650sjwyy	55	15	,	,	,
cord-275730-650sjwyy	55	16	cholera	cholera	NN
cord-275730-650sjwyy	55	17	toxin	toxin	NN
cord-275730-650sjwyy	55	18	,	,	,
cord-275730-650sjwyy	55	19	and	and	CC
cord-275730-650sjwyy	55	20	E.	E.	NNP
cord-275730-650sjwyy	55	21	coli	coli	VBZ
cord-275730-650sjwyy	55	22	heat	heat	NN
cord-275730-650sjwyy	55	23	-	-	HYPH
cord-275730-650sjwyy	55	24	labile	labile	JJ
cord-275730-650sjwyy	55	25	toxin	toxin	NN
cord-275730-650sjwyy	55	26	.	.	.
cord-275730-650sjwyy	56	1	Mechanistically	Mechanistically	NNP
cord-275730-650sjwyy	56	2	,	,	,
cord-275730-650sjwyy	56	3	these	these	DT
cord-275730-650sjwyy	56	4	toxins	toxin	NNS
cord-275730-650sjwyy	56	5	form	form	VBP
cord-275730-650sjwyy	56	6	a	a	DT
cord-275730-650sjwyy	56	7	pentameric	pentameric	NN
cord-275730-650sjwyy	56	8	subunit	subunit	NN
cord-275730-650sjwyy	56	9	,	,	,
cord-275730-650sjwyy	56	10	which	which	WDT
cord-275730-650sjwyy	56	11	binds	bind	VBZ
cord-275730-650sjwyy	56	12	to	to	IN
cord-275730-650sjwyy	56	13	the	the	DT
cord-275730-650sjwyy	56	14	gangliosides	ganglioside	NNS
cord-275730-650sjwyy	56	15	(	(	-LRB-
cord-275730-650sjwyy	56	16	preferentially	preferentially	RB
cord-275730-650sjwyy	56	17	GM1	GM1	NNP
cord-275730-650sjwyy	56	18	)	)	-RRB-
cord-275730-650sjwyy	56	19	,	,	,
cord-275730-650sjwyy	56	20	thereby	thereby	RB
cord-275730-650sjwyy	56	21	facilitating	facilitate	VBG
cord-275730-650sjwyy	56	22	the	the	DT
cord-275730-650sjwyy	56	23	uptake	uptake	NN
cord-275730-650sjwyy	56	24	.	.	.
cord-275730-650sjwyy	57	1	Recent	recent	JJ
cord-275730-650sjwyy	57	2	studies	study	NNS
cord-275730-650sjwyy	57	3	,	,	,
cord-275730-650sjwyy	57	4	however	however	RB
cord-275730-650sjwyy	57	5	,	,	,
cord-275730-650sjwyy	57	6	raised	raise	VBD
cord-275730-650sjwyy	57	7	safety	safety	NN
cord-275730-650sjwyy	57	8	concerns	concern	NNS
cord-275730-650sjwyy	57	9	.	.	.
cord-275730-650sjwyy	58	1	Studies	study	NNS
cord-275730-650sjwyy	58	2	found	find	VBD
cord-275730-650sjwyy	58	3	that	that	IN
cord-275730-650sjwyy	58	4	the	the	DT
cord-275730-650sjwyy	58	5	enterotoxins	enterotoxin	NNS
cord-275730-650sjwyy	58	6	are	be	VBP
cord-275730-650sjwyy	58	7	accumulated	accumulate	VBN
cord-275730-650sjwyy	58	8	in	in	IN
cord-275730-650sjwyy	58	9	the	the	DT
cord-275730-650sjwyy	58	10	olfactory	olfactory	JJ
cord-275730-650sjwyy	58	11	epithelium	epithelium	NN
cord-275730-650sjwyy	58	12	nerves	nerve	NNS
cord-275730-650sjwyy	58	13	and	and	CC
cord-275730-650sjwyy	58	14	the	the	DT
cord-275730-650sjwyy	58	15	olfactory	olfactory	JJ
cord-275730-650sjwyy	58	16	bulb	bulb	NN
cord-275730-650sjwyy	58	17	that	that	WDT
cord-275730-650sjwyy	58	18	induce	induce	VBP
cord-275730-650sjwyy	58	19	inflammatory	inflammatory	JJ
cord-275730-650sjwyy	58	20	responses	response	NNS
cord-275730-650sjwyy	58	21	in	in	IN
cord-275730-650sjwyy	58	22	meninges	meninge	NNS
cord-275730-650sjwyy	58	23	,	,	,
cord-275730-650sjwyy	58	24	the	the	DT
cord-275730-650sjwyy	58	25	olfactory	olfactory	JJ
cord-275730-650sjwyy	58	26	nerve	nerve	NN
cord-275730-650sjwyy	58	27	,	,	,
cord-275730-650sjwyy	58	28	and	and	CC
cord-275730-650sjwyy	58	29	glomerular	glomerular	JJ
cord-275730-650sjwyy	58	30	layers	layer	NNS
cord-275730-650sjwyy	58	31	of	of	IN
cord-275730-650sjwyy	58	32	the	the	DT
cord-275730-650sjwyy	58	33	olfactory	olfactory	JJ
cord-275730-650sjwyy	58	34	bulb	bulb	NN
cord-275730-650sjwyy	58	35	promoting	promote	VBG
cord-275730-650sjwyy	58	36	neuronal	neuronal	JJ
cord-275730-650sjwyy	58	37	damage	damage	NN
cord-275730-650sjwyy	58	38	[	[	-LRB-
cord-275730-650sjwyy	58	39	40	40	CD
cord-275730-650sjwyy	58	40	]	]	-RRB-
cord-275730-650sjwyy	58	41	[	[	-LRB-
cord-275730-650sjwyy	58	42	41	41	CD
cord-275730-650sjwyy	58	43	]	]	-RRB-
cord-275730-650sjwyy	58	44	[	[	-LRB-
cord-275730-650sjwyy	58	45	42	42	CD
cord-275730-650sjwyy	58	46	]	]	-RRB-
cord-275730-650sjwyy	58	47	.	.	.
cord-275730-650sjwyy	59	1	CDNs	CDNs	NNP
cord-275730-650sjwyy	59	2	have	have	VBP
cord-275730-650sjwyy	59	3	received	receive	VBN
cord-275730-650sjwyy	59	4	enormous	enormous	JJ
cord-275730-650sjwyy	59	5	interest	interest	NN
cord-275730-650sjwyy	59	6	as	as	IN
cord-275730-650sjwyy	59	7	potential	potential	JJ
cord-275730-650sjwyy	59	8	mucosal	mucosal	JJ
cord-275730-650sjwyy	59	9	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	59	10	.	.	.
cord-275730-650sjwyy	60	1	In	in	IN
cord-275730-650sjwyy	60	2	2007	2007	CD
cord-275730-650sjwyy	60	3	,	,	,
cord-275730-650sjwyy	60	4	Ebensen	Ebensen	NNP
cord-275730-650sjwyy	60	5	et	et	NNP
cord-275730-650sjwyy	60	6	al	al	NNP
cord-275730-650sjwyy	60	7	.	.	.
cord-275730-650sjwyy	61	1	first	first	RB
cord-275730-650sjwyy	61	2	demonstrated	demonstrate	VBD
cord-275730-650sjwyy	61	3	CDNs	CDNs	NNP
cord-275730-650sjwyy	61	4	as	as	IN
cord-275730-650sjwyy	61	5	a	a	DT
cord-275730-650sjwyy	61	6	mucosal	mucosal	JJ
cord-275730-650sjwyy	61	7	adjuvant	adjuvant	NN
cord-275730-650sjwyy	61	8	[	[	-LRB-
cord-275730-650sjwyy	61	9	9	9	CD
cord-275730-650sjwyy	61	10	]	]	-RRB-
cord-275730-650sjwyy	61	11	.	.	.
cord-275730-650sjwyy	62	1	They	-PRON-	PRP
cord-275730-650sjwyy	62	2	showed	show	VBD
cord-275730-650sjwyy	62	3	that	that	IN
cord-275730-650sjwyy	62	4	CDG	CDG	NNP
cord-275730-650sjwyy	62	5	/	/	SYM
cord-275730-650sjwyy	62	6	β	β	NN
cord-275730-650sjwyy	62	7	-	-	HYPH
cord-275730-650sjwyy	62	8	Gal	Gal	NNP
cord-275730-650sjwyy	62	9	i.n	i.n	NN
cord-275730-650sjwyy	62	10	.	.	.
cord-275730-650sjwyy	63	1	immunized	immunized	JJ
cord-275730-650sjwyy	63	2	mice	mouse	NNS
cord-275730-650sjwyy	63	3	not	not	RB
cord-275730-650sjwyy	63	4	only	only	RB
cord-275730-650sjwyy	63	5	mounted	mount	VBD
cord-275730-650sjwyy	63	6	a	a	DT
cord-275730-650sjwyy	63	7	systemic	systemic	JJ
cord-275730-650sjwyy	63	8	IgG	igg	NN
cord-275730-650sjwyy	63	9	response	response	NN
cord-275730-650sjwyy	63	10	but	but	CC
cord-275730-650sjwyy	63	11	also	also	RB
cord-275730-650sjwyy	63	12	generated	generate	VBD
cord-275730-650sjwyy	63	13	an	an	DT
cord-275730-650sjwyy	63	14	enhanced	enhanced	JJ
cord-275730-650sjwyy	63	15	β	β	NN
cord-275730-650sjwyy	63	16	-	-	HYPH
cord-275730-650sjwyy	63	17	Gal	gal	NN
cord-275730-650sjwyy	63	18	specific	specific	JJ
cord-275730-650sjwyy	63	19	IgA	iga	NN
cord-275730-650sjwyy	63	20	response	response	NN
cord-275730-650sjwyy	63	21	after	after	IN
cord-275730-650sjwyy	63	22	42	42	CD
cord-275730-650sjwyy	63	23	days	day	NNS
cord-275730-650sjwyy	63	24	in	in	IN
cord-275730-650sjwyy	63	25	lung	lung	NN
cord-275730-650sjwyy	63	26	BALF	BALF	NNP
cord-275730-650sjwyy	63	27	and	and	CC
cord-275730-650sjwyy	63	28	vaginal	vaginal	JJ
cord-275730-650sjwyy	63	29	lavage	lavage	NN
cord-275730-650sjwyy	63	30	[	[	-LRB-
cord-275730-650sjwyy	63	31	9	9	CD
cord-275730-650sjwyy	63	32	]	]	-RRB-
cord-275730-650sjwyy	63	33	.	.	.
cord-275730-650sjwyy	64	1	Intranasal	intranasal	NN
cord-275730-650sjwyy	64	2	immunization	immunization	NN
cord-275730-650sjwyy	64	3	of	of	IN
cord-275730-650sjwyy	64	4	CDG	CDG	NNP
cord-275730-650sjwyy	64	5	/	/	SYM
cord-275730-650sjwyy	64	6	β	β	NN
cord-275730-650sjwyy	64	7	-	-	:
cord-275730-650sjwyy	64	8	Gal	Gal	NNP
cord-275730-650sjwyy	64	9	also	also	RB
cord-275730-650sjwyy	64	10	enhanced	enhance	VBD
cord-275730-650sjwyy	64	11	the	the	DT
cord-275730-650sjwyy	64	12	serum	serum	NN
cord-275730-650sjwyy	64	13	IgG2a	IgG2a	NNP
cord-275730-650sjwyy	64	14	and	and	CC
cord-275730-650sjwyy	64	15	IgG1	IgG1	NNP
cord-275730-650sjwyy	64	16	production	production	NN
cord-275730-650sjwyy	64	17	by	by	IN
cord-275730-650sjwyy	64	18	640-and	640-and	CD
cord-275730-650sjwyy	64	19	320-fold	320-fold	CD
cord-275730-650sjwyy	64	20	as	as	IN
cord-275730-650sjwyy	64	21	compared	compare	VBN
cord-275730-650sjwyy	64	22	to	to	IN
cord-275730-650sjwyy	64	23	only	only	RB
cord-275730-650sjwyy	64	24	β	β	NN
cord-275730-650sjwyy	64	25	-	-	HYPH
cord-275730-650sjwyy	64	26	Gal	gal	NN
cord-275730-650sjwyy	64	27	immunized	immunize	VBN
cord-275730-650sjwyy	64	28	mice	mouse	NNS
cord-275730-650sjwyy	64	29	[	[	-LRB-
cord-275730-650sjwyy	64	30	9	9	CD
cord-275730-650sjwyy	64	31	]	]	-RRB-
cord-275730-650sjwyy	64	32	.	.	.
cord-275730-650sjwyy	65	1	The	the	DT
cord-275730-650sjwyy	65	2	systemic	systemic	JJ
cord-275730-650sjwyy	65	3	cellular	cellular	JJ
cord-275730-650sjwyy	65	4	response	response	NN
cord-275730-650sjwyy	65	5	was	be	VBD
cord-275730-650sjwyy	65	6	also	also	RB
cord-275730-650sjwyy	65	7	enhanced	enhance	VBN
cord-275730-650sjwyy	65	8	by	by	IN
cord-275730-650sjwyy	65	9	CDG	CDG	NNP
cord-275730-650sjwyy	65	10	/	/	SYM
cord-275730-650sjwyy	65	11	β	β	NN
cord-275730-650sjwyy	65	12	-	-	HYPH
cord-275730-650sjwyy	65	13	Gal	gal	NN
cord-275730-650sjwyy	65	14	immunization	immunization	NN
cord-275730-650sjwyy	65	15	,	,	,
cord-275730-650sjwyy	65	16	as	as	IN
cord-275730-650sjwyy	65	17	was	be	VBD
cord-275730-650sjwyy	65	18	observed	observe	VBN
cord-275730-650sjwyy	65	19	with	with	IN
cord-275730-650sjwyy	65	20	the	the	DT
cord-275730-650sjwyy	65	21	production	production	NN
cord-275730-650sjwyy	65	22	of	of	IN
cord-275730-650sjwyy	65	23	interferon	interferon	NN
cord-275730-650sjwyy	65	24	(	(	-LRB-
cord-275730-650sjwyy	65	25	IFN)-γ	ifn)-γ	NN
cord-275730-650sjwyy	65	26	(	(	-LRB-
cord-275730-650sjwyy	65	27	2000-fold	2000-fold	CD
cord-275730-650sjwyy	65	28	)	)	-RRB-
cord-275730-650sjwyy	65	29	,	,	,
cord-275730-650sjwyy	65	30	IL-5	IL-5	NNP
cord-275730-650sjwyy	65	31	,	,	,
cord-275730-650sjwyy	65	32	and	and	CC
cord-275730-650sjwyy	65	33	IL-2	IL-2	NNP
cord-275730-650sjwyy	65	34	in	in	IN
cord-275730-650sjwyy	65	35	the	the	DT
cord-275730-650sjwyy	65	36	ex	ex	FW
cord-275730-650sjwyy	65	37	vivo	vivo	NN
cord-275730-650sjwyy	65	38	recall	recall	NN
cord-275730-650sjwyy	65	39	assay	assay	NN
cord-275730-650sjwyy	65	40	compared	compare	VBN
cord-275730-650sjwyy	65	41	to	to	IN
cord-275730-650sjwyy	65	42	only	only	RB
cord-275730-650sjwyy	65	43	β	β	NN
cord-275730-650sjwyy	65	44	-	-	HYPH
cord-275730-650sjwyy	65	45	Gal	gal	NN
cord-275730-650sjwyy	65	46	immunized	immunize	VBN
cord-275730-650sjwyy	65	47	mice	mouse	NNS
cord-275730-650sjwyy	65	48	[	[	-LRB-
cord-275730-650sjwyy	65	49	9	9	CD
cord-275730-650sjwyy	65	50	]	]	-RRB-
cord-275730-650sjwyy	65	51	.	.	.
cord-275730-650sjwyy	66	1	CDNs	CDNs	NNP
cord-275730-650sjwyy	66	2	also	also	RB
cord-275730-650sjwyy	66	3	induce	induce	VBP
cord-275730-650sjwyy	66	4	mucosal	mucosal	JJ
cord-275730-650sjwyy	66	5	Th17	Th17	NNP
cord-275730-650sjwyy	66	6	[	[	-LRB-
cord-275730-650sjwyy	66	7	7	7	CD
cord-275730-650sjwyy	66	8	,	,	,
cord-275730-650sjwyy	66	9	19	19	CD
cord-275730-650sjwyy	66	10	]	]	-RRB-
cord-275730-650sjwyy	66	11	.	.	.
cord-275730-650sjwyy	67	1	The	the	DT
cord-275730-650sjwyy	67	2	mucosal	mucosal	JJ
cord-275730-650sjwyy	67	3	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	67	4	potential	potential	NN
cord-275730-650sjwyy	67	5	of	of	IN
cord-275730-650sjwyy	67	6	CDNs	cdn	NNS
cord-275730-650sjwyy	67	7	was	be	VBD
cord-275730-650sjwyy	67	8	further	further	RB
cord-275730-650sjwyy	67	9	strengthened	strengthen	VBN
cord-275730-650sjwyy	67	10	when	when	WRB
cord-275730-650sjwyy	67	11	Madhun	Madhun	NNP
cord-275730-650sjwyy	67	12	et	et	NNP
cord-275730-650sjwyy	67	13	al	al	NNP
cord-275730-650sjwyy	67	14	.	.	NNP
cord-275730-650sjwyy	67	15	showed	show	VBD
cord-275730-650sjwyy	67	16	that	that	IN
cord-275730-650sjwyy	67	17	i.n	i.n	NNP
cord-275730-650sjwyy	67	18	.	.	NNP
cord-275730-650sjwyy	67	19	administration	administration	NN
cord-275730-650sjwyy	67	20	of	of	IN
cord-275730-650sjwyy	67	21	a	a	DT
cord-275730-650sjwyy	67	22	plant	plant	NN
cord-275730-650sjwyy	67	23	-	-	HYPH
cord-275730-650sjwyy	67	24	based	base	VBN
cord-275730-650sjwyy	67	25	H5N1	H5N1	NNP
cord-275730-650sjwyy	67	26	influenza	influenza	NN
cord-275730-650sjwyy	67	27	antigen	antigen	NN
cord-275730-650sjwyy	67	28	induced	induce	VBD
cord-275730-650sjwyy	67	29	high	high	JJ
cord-275730-650sjwyy	67	30	frequencies	frequency	NNS
cord-275730-650sjwyy	67	31	of	of	IN
cord-275730-650sjwyy	67	32	multifunctional	multifunctional	JJ
cord-275730-650sjwyy	67	33	Th1	th1	NN
cord-275730-650sjwyy	67	34	cells	cell	NNS
cord-275730-650sjwyy	67	35	[	[	-LRB-
cord-275730-650sjwyy	67	36	8	8	CD
cord-275730-650sjwyy	67	37	]	]	-RRB-
cord-275730-650sjwyy	67	38	.	.	.
cord-275730-650sjwyy	68	1	Two	two	CD
cord-275730-650sjwyy	68	2	doses	dose	NNS
cord-275730-650sjwyy	68	3	of	of	IN
cord-275730-650sjwyy	68	4	the	the	DT
cord-275730-650sjwyy	68	5	CDG	CDG	NNP
cord-275730-650sjwyy	68	6	adjuvanted	adjuvante	VBN
cord-275730-650sjwyy	68	7	vaccine	vaccine	NN
cord-275730-650sjwyy	68	8	were	be	VBD
cord-275730-650sjwyy	68	9	able	able	JJ
cord-275730-650sjwyy	68	10	to	to	TO
cord-275730-650sjwyy	68	11	mount	mount	VB
cord-275730-650sjwyy	68	12	a	a	DT
cord-275730-650sjwyy	68	13	very	very	RB
cord-275730-650sjwyy	68	14	high	high	JJ
cord-275730-650sjwyy	68	15	mucosal	mucosal	JJ
cord-275730-650sjwyy	68	16	IgA	IgA	NNP
cord-275730-650sjwyy	68	17	response	response	NN
cord-275730-650sjwyy	68	18	and	and	CC
cord-275730-650sjwyy	68	19	protected	protect	VBN
cord-275730-650sjwyy	68	20	against	against	IN
cord-275730-650sjwyy	68	21	antigenically	antigenically	RB
cord-275730-650sjwyy	68	22	drifted	drift	VBN
cord-275730-650sjwyy	68	23	H5N1	H5N1	NNP
cord-275730-650sjwyy	68	24	viruses	virus	NNS
cord-275730-650sjwyy	68	25	[	[	-LRB-
cord-275730-650sjwyy	68	26	8	8	CD
cord-275730-650sjwyy	68	27	]	]	-RRB-
cord-275730-650sjwyy	68	28	.	.	.
cord-275730-650sjwyy	69	1	In	in	IN
cord-275730-650sjwyy	69	2	comparison	comparison	NN
cord-275730-650sjwyy	69	3	,	,	,
cord-275730-650sjwyy	69	4	the	the	DT
cord-275730-650sjwyy	69	5	same	same	JJ
cord-275730-650sjwyy	69	6	vaccine	vaccine	NN
cord-275730-650sjwyy	69	7	when	when	WRB
cord-275730-650sjwyy	69	8	it	-PRON-	PRP
cord-275730-650sjwyy	69	9	immunized	immunize	VBD
cord-275730-650sjwyy	69	10	i.m	i.m	NNP
cord-275730-650sjwyy	69	11	.	.	NNP
cord-275730-650sjwyy	69	12	did	do	VBD
cord-275730-650sjwyy	69	13	not	not	RB
cord-275730-650sjwyy	69	14	generate	generate	VB
cord-275730-650sjwyy	69	15	a	a	DT
cord-275730-650sjwyy	69	16	Th1	th1	CD
cord-275730-650sjwyy	69	17	response	response	NN
cord-275730-650sjwyy	69	18	,	,	,
cord-275730-650sjwyy	69	19	which	which	WDT
cord-275730-650sjwyy	69	20	is	be	VBZ
cord-275730-650sjwyy	69	21	critical	critical	JJ
cord-275730-650sjwyy	69	22	for	for	IN
cord-275730-650sjwyy	69	23	viral	viral	JJ
cord-275730-650sjwyy	69	24	infections	infection	NNS
cord-275730-650sjwyy	69	25	[	[	-LRB-
cord-275730-650sjwyy	69	26	8	8	CD
cord-275730-650sjwyy	69	27	]	]	-RRB-
cord-275730-650sjwyy	69	28	.	.	.
cord-275730-650sjwyy	70	1	The	the	DT
cord-275730-650sjwyy	70	2	safety	safety	NN
cord-275730-650sjwyy	70	3	profile	profile	NN
cord-275730-650sjwyy	70	4	of	of	IN
cord-275730-650sjwyy	70	5	the	the	DT
cord-275730-650sjwyy	70	6	vaccine	vaccine	NN
cord-275730-650sjwyy	70	7	adjuvant	adjuvant	NN
cord-275730-650sjwyy	70	8	is	be	VBZ
cord-275730-650sjwyy	70	9	crucial	crucial	JJ
cord-275730-650sjwyy	70	10	while	while	IN
cord-275730-650sjwyy	70	11	administration	administration	NN
cord-275730-650sjwyy	70	12	avoids	avoid	VBZ
cord-275730-650sjwyy	70	13	unwanted	unwanted	JJ
cord-275730-650sjwyy	70	14	side	side	NN
cord-275730-650sjwyy	70	15	effects	effect	NNS
cord-275730-650sjwyy	70	16	.	.	.
cord-275730-650sjwyy	71	1	Histopathology	Histopathology	NNP
cord-275730-650sjwyy	71	2	studies	study	NNS
cord-275730-650sjwyy	71	3	and	and	CC
cord-275730-650sjwyy	71	4	cytokine	cytokine	NN
cord-275730-650sjwyy	71	5	profiling	profiling	NN
cord-275730-650sjwyy	71	6	suggested	suggest	VBD
cord-275730-650sjwyy	71	7	that	that	IN
cord-275730-650sjwyy	71	8	the	the	DT
cord-275730-650sjwyy	71	9	CDG	CDG	NNP
cord-275730-650sjwyy	71	10	adjuvanted	adjuvante	VBN
cord-275730-650sjwyy	71	11	vaccine	vaccine	NN
cord-275730-650sjwyy	71	12	also	also	RB
cord-275730-650sjwyy	71	13	induced	induce	VBD
cord-275730-650sjwyy	71	14	the	the	DT
cord-275730-650sjwyy	71	15	production	production	NN
cord-275730-650sjwyy	71	16	of	of	IN
cord-275730-650sjwyy	71	17	anti	anti	JJ
cord-275730-650sjwyy	71	18	-	-	JJ
cord-275730-650sjwyy	71	19	inflammatory	inflammatory	JJ
cord-275730-650sjwyy	71	20	cytokine	cytokine	NN
cord-275730-650sjwyy	71	21	-	-	:
cord-275730-650sjwyy	71	22	like	like	IN
cord-275730-650sjwyy	71	23	IL-10	IL-10	NNP
cord-275730-650sjwyy	71	24	,	,	,
cord-275730-650sjwyy	71	25	thereby	thereby	RB
cord-275730-650sjwyy	71	26	maintaining	maintain	VBG
cord-275730-650sjwyy	71	27	a	a	DT
cord-275730-650sjwyy	71	28	balanced	balanced	JJ
cord-275730-650sjwyy	71	29	pro	pro	JJ
cord-275730-650sjwyy	71	30	-	-	JJ
cord-275730-650sjwyy	71	31	and	and	CC
cord-275730-650sjwyy	71	32	anti	anti	JJ
cord-275730-650sjwyy	71	33	-	-	JJ
cord-275730-650sjwyy	71	34	inflammatory	inflammatory	JJ
cord-275730-650sjwyy	71	35	cytokine	cytokine	NN
cord-275730-650sjwyy	71	36	profile	profile	NN
cord-275730-650sjwyy	71	37	[	[	-LRB-
cord-275730-650sjwyy	71	38	43	43	CD
cord-275730-650sjwyy	71	39	]	]	-RRB-
cord-275730-650sjwyy	71	40	.	.	.
cord-275730-650sjwyy	72	1	CDG	CDG	NNP
cord-275730-650sjwyy	72	2	also	also	RB
cord-275730-650sjwyy	72	3	induced	induce	VBD
cord-275730-650sjwyy	72	4	the	the	DT
cord-275730-650sjwyy	72	5	production	production	NN
cord-275730-650sjwyy	72	6	of	of	IN
cord-275730-650sjwyy	72	7	IL-22	IL-22	NNP
cord-275730-650sjwyy	72	8	,	,	,
cord-275730-650sjwyy	72	9	thereby	thereby	RB
cord-275730-650sjwyy	72	10	facilitating	facilitate	VBG
cord-275730-650sjwyy	72	11	lung	lung	NN
cord-275730-650sjwyy	72	12	epithelium	epithelium	NN
cord-275730-650sjwyy	72	13	repair	repair	NN
cord-275730-650sjwyy	72	14	along	along	IN
cord-275730-650sjwyy	72	15	with	with	IN
cord-275730-650sjwyy	72	16	effectively	effectively	RB
cord-275730-650sjwyy	72	17	clearing	clear	VBG
cord-275730-650sjwyy	72	18	S.	S.	NNP
cord-275730-650sjwyy	72	19	pneumoniae	pneumoniae	NN
cord-275730-650sjwyy	72	20	from	from	IN
cord-275730-650sjwyy	72	21	the	the	DT
cord-275730-650sjwyy	72	22	organs	organ	NNS
cord-275730-650sjwyy	72	23	[	[	-LRB-
cord-275730-650sjwyy	72	24	43	43	CD
cord-275730-650sjwyy	72	25	]	]	-RRB-
cord-275730-650sjwyy	72	26	.	.	.
cord-275730-650sjwyy	73	1	Thus	thus	RB
cord-275730-650sjwyy	73	2	,	,	,
cord-275730-650sjwyy	73	3	CDNs	cdn	NNS
cord-275730-650sjwyy	73	4	have	have	VBP
cord-275730-650sjwyy	73	5	shown	show	VBN
cord-275730-650sjwyy	73	6	promising	promising	JJ
cord-275730-650sjwyy	73	7	and	and	CC
cord-275730-650sjwyy	73	8	safe	safe	JJ
cord-275730-650sjwyy	73	9	mucosal	mucosal	JJ
cord-275730-650sjwyy	73	10	vaccine	vaccine	NN
cord-275730-650sjwyy	73	11	activities	activity	NNS
cord-275730-650sjwyy	73	12	in	in	IN
cord-275730-650sjwyy	73	13	animal	animal	NN
cord-275730-650sjwyy	73	14	models	model	NNS
cord-275730-650sjwyy	73	15	.	.	.
cord-275730-650sjwyy	74	1	Distinct	distinct	JJ
cord-275730-650sjwyy	74	2	from	from	IN
cord-275730-650sjwyy	74	3	the	the	DT
cord-275730-650sjwyy	74	4	CDN	CDN	NNP
cord-275730-650sjwyy	74	5	-	-	HYPH
cord-275730-650sjwyy	74	6	STING	sting	NN
cord-275730-650sjwyy	74	7	-	-	HYPH
cord-275730-650sjwyy	74	8	type	type	NN
cord-275730-650sjwyy	74	9	I	-PRON-	PRP
cord-275730-650sjwyy	74	10	IFNs	ifns	NN
cord-275730-650sjwyy	74	11	-	-	HYPH
cord-275730-650sjwyy	74	12	immunity	immunity	NN
cord-275730-650sjwyy	74	13	paradigm	paradigm	NN
cord-275730-650sjwyy	74	14	,	,	,
cord-275730-650sjwyy	74	15	Andrew	Andrew	NNP
cord-275730-650sjwyy	74	16	Mellor	Mellor	NNP
cord-275730-650sjwyy	74	17	's	's	POS
cord-275730-650sjwyy	74	18	group	group	NN
cord-275730-650sjwyy	74	19	described	describe	VBD
cord-275730-650sjwyy	74	20	a	a	DT
cord-275730-650sjwyy	74	21	CDN	CDN	NNP
cord-275730-650sjwyy	74	22	-	-	HYPH
cord-275730-650sjwyy	74	23	STING	sting	NN
cord-275730-650sjwyy	74	24	-	-	HYPH
cord-275730-650sjwyy	74	25	type	type	NN
cord-275730-650sjwyy	74	26	I	-PRON-	PRP
cord-275730-650sjwyy	74	27	IFNs	ifns	NN
cord-275730-650sjwyy	74	28	-	-	:
cord-275730-650sjwyy	74	29	IDO1-tolerance	ido1-tolerance	NN
cord-275730-650sjwyy	74	30	signaling	signaling	NN
cord-275730-650sjwyy	74	31	that	that	WDT
cord-275730-650sjwyy	74	32	mediates	mediate	VBZ
cord-275730-650sjwyy	74	33	potent	potent	JJ
cord-275730-650sjwyy	74	34	T	T	NNP
cord-275730-650sjwyy	74	35	-	-	HYPH
cord-275730-650sjwyy	74	36	reg	reg	NN
cord-275730-650sjwyy	74	37	responses	response	NNS
cord-275730-650sjwyy	74	38	and	and	CC
cord-275730-650sjwyy	74	39	suppresses	suppress	VBZ
cord-275730-650sjwyy	74	40	inflammation	inflammation	NN
cord-275730-650sjwyy	74	41	[	[	-LRB-
cord-275730-650sjwyy	74	42	44	44	CD
cord-275730-650sjwyy	74	43	]	]	-RRB-
cord-275730-650sjwyy	74	44	.	.	.
cord-275730-650sjwyy	75	1	They	-PRON-	PRP
cord-275730-650sjwyy	75	2	first	first	RB
cord-275730-650sjwyy	75	3	showed	show	VBD
cord-275730-650sjwyy	75	4	that	that	IN
cord-275730-650sjwyy	75	5	DNA	dna	NN
cord-275730-650sjwyy	75	6	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	75	7	(	(	-LRB-
cord-275730-650sjwyy	75	8	DNP	DNP	NNP
cord-275730-650sjwyy	75	9	,	,	,
cord-275730-650sjwyy	75	10	containing	contain	VBG
cord-275730-650sjwyy	75	11	PEI	PEI	NNP
cord-275730-650sjwyy	75	12	and	and	CC
cord-275730-650sjwyy	75	13	plasmid	plasmid	NN
cord-275730-650sjwyy	75	14	DNA	dna	NN
cord-275730-650sjwyy	75	15	lacking	lack	VBG
cord-275730-650sjwyy	75	16	TLR9	tlr9	CD
cord-275730-650sjwyy	75	17	ligands	ligand	NNS
cord-275730-650sjwyy	75	18	)	)	-RRB-
cord-275730-650sjwyy	75	19	activate	activate	VBP
cord-275730-650sjwyy	75	20	STING	sting	NN
cord-275730-650sjwyy	75	21	-	-	HYPH
cord-275730-650sjwyy	75	22	dependent	dependent	JJ
cord-275730-650sjwyy	75	23	IDO-1	IDO-1	NNP
cord-275730-650sjwyy	75	24	production	production	NN
cord-275730-650sjwyy	75	25	that	that	WDT
cord-275730-650sjwyy	75	26	induces	induce	VBZ
cord-275730-650sjwyy	75	27	tolerance	tolerance	NN
cord-275730-650sjwyy	75	28	[	[	-LRB-
cord-275730-650sjwyy	75	29	44	44	CD
cord-275730-650sjwyy	75	30	]	]	-RRB-
cord-275730-650sjwyy	75	31	.	.	.
cord-275730-650sjwyy	76	1	Later	later	RB
cord-275730-650sjwyy	76	2	,	,	,
cord-275730-650sjwyy	76	3	they	-PRON-	PRP
cord-275730-650sjwyy	76	4	showed	show	VBD
cord-275730-650sjwyy	76	5	that	that	IN
cord-275730-650sjwyy	76	6	the	the	DT
cord-275730-650sjwyy	76	7	CDG	CDG	NNP
cord-275730-650sjwyy	76	8	treatment	treatment	NN
cord-275730-650sjwyy	76	9	delayed	delay	VBD
cord-275730-650sjwyy	76	10	the	the	DT
cord-275730-650sjwyy	76	11	experimental	experimental	JJ
cord-275730-650sjwyy	76	12	autoimmune	autoimmune	NN
cord-275730-650sjwyy	76	13	encephalitis	encephalitis	RB
cord-275730-650sjwyy	76	14	(	(	-LRB-
cord-275730-650sjwyy	76	15	EAE	EAE	NNP
cord-275730-650sjwyy	76	16	)	)	-RRB-
cord-275730-650sjwyy	76	17	onset	onset	NN
cord-275730-650sjwyy	76	18	and	and	CC
cord-275730-650sjwyy	76	19	reduced	reduced	JJ
cord-275730-650sjwyy	76	20	disease	disease	NN
cord-275730-650sjwyy	76	21	severity	severity	NN
cord-275730-650sjwyy	76	22	[	[	-LRB-
cord-275730-650sjwyy	76	23	45	45	CD
cord-275730-650sjwyy	76	24	]	]	-RRB-
cord-275730-650sjwyy	76	25	.	.	.
cord-275730-650sjwyy	77	1	They	-PRON-	PRP
cord-275730-650sjwyy	77	2	identified	identify	VBD
cord-275730-650sjwyy	77	3	a	a	DT
cord-275730-650sjwyy	77	4	new	new	JJ
cord-275730-650sjwyy	77	5	CDG	CDG	NNP
cord-275730-650sjwyy	77	6	-	-	HYPH
cord-275730-650sjwyy	77	7	STING	sting	NN
cord-275730-650sjwyy	77	8	/	/	SYM
cord-275730-650sjwyy	77	9	type	type	NN
cord-275730-650sjwyy	77	10	I	-PRON-	PRP
cord-275730-650sjwyy	77	11	IFNs/	ifns/	NN
cord-275730-650sjwyy	78	1	IDO1	IDO1	NNP
cord-275730-650sjwyy	78	2	/	/	SYM
cord-275730-650sjwyy	78	3	Tregs	Tregs	NNP
cord-275730-650sjwyy	78	4	pathway	pathway	NN
cord-275730-650sjwyy	78	5	that	that	WDT
cord-275730-650sjwyy	78	6	suppresses	suppress	VBZ
cord-275730-650sjwyy	78	7	CNS	cns	NN
cord-275730-650sjwyy	78	8	-	-	HYPH
cord-275730-650sjwyy	78	9	specific	specific	JJ
cord-275730-650sjwyy	78	10	autoimmunity	autoimmunity	NN
cord-275730-650sjwyy	78	11	[	[	-LRB-
cord-275730-650sjwyy	78	12	45	45	CD
cord-275730-650sjwyy	78	13	]	]	-RRB-
cord-275730-650sjwyy	78	14	.	.	.
cord-275730-650sjwyy	79	1	Recently	recently	RB
cord-275730-650sjwyy	79	2	,	,	,
cord-275730-650sjwyy	79	3	the	the	DT
cord-275730-650sjwyy	79	4	same	same	JJ
cord-275730-650sjwyy	79	5	group	group	NN
cord-275730-650sjwyy	79	6	showed	show	VBD
cord-275730-650sjwyy	79	7	that	that	IN
cord-275730-650sjwyy	79	8	the	the	DT
cord-275730-650sjwyy	79	9	CDN	CDN	NNP
cord-275730-650sjwyy	79	10	-	-	HYPH
cord-275730-650sjwyy	79	11	STING	STING	NNP
cord-275730-650sjwyy	79	12	-	-	HYPH
cord-275730-650sjwyy	79	13	IDO-1	IDO-1	NNP
cord-275730-650sjwyy	79	14	activity	activity	NN
cord-275730-650sjwyy	79	15	in	in	IN
cord-275730-650sjwyy	79	16	the	the	DT
cord-275730-650sjwyy	79	17	tumor	tumor	NN
cord-275730-650sjwyy	79	18	microenvironment	microenvironment	NN
cord-275730-650sjwyy	79	19	(	(	-LRB-
cord-275730-650sjwyy	79	20	TME	TME	NNP
cord-275730-650sjwyy	79	21	)	)	-RRB-
cord-275730-650sjwyy	79	22	promoted	promote	VBD
cord-275730-650sjwyy	79	23	the	the	DT
cord-275730-650sjwyy	79	24	growth	growth	NN
cord-275730-650sjwyy	79	25	of	of	IN
cord-275730-650sjwyy	79	26	low	low	JJ
cord-275730-650sjwyy	79	27	antigenicity	antigenicity	NN
cord-275730-650sjwyy	79	28	Lewis	Lewis	NNP
cord-275730-650sjwyy	79	29	lung	lung	NN
cord-275730-650sjwyy	79	30	carcinoma	carcinoma	NN
cord-275730-650sjwyy	79	31	(	(	-LRB-
cord-275730-650sjwyy	79	32	LLC	LLC	NNP
cord-275730-650sjwyy	79	33	)	)	-RRB-
cord-275730-650sjwyy	80	1	[	[	-LRB-
cord-275730-650sjwyy	80	2	46	46	CD
cord-275730-650sjwyy	80	3	]	]	-RRB-
cord-275730-650sjwyy	80	4	.	.	.
cord-275730-650sjwyy	81	1	Lastly	lastly	RB
cord-275730-650sjwyy	81	2	,	,	,
cord-275730-650sjwyy	81	3	they	-PRON-	PRP
cord-275730-650sjwyy	81	4	showed	show	VBD
cord-275730-650sjwyy	81	5	that	that	IN
cord-275730-650sjwyy	81	6	treating	treat	VBG
cord-275730-650sjwyy	81	7	pre	pre	JJ
cord-275730-650sjwyy	81	8	-	-	JJ
cord-275730-650sjwyy	81	9	diabetic	diabetic	JJ
cord-275730-650sjwyy	81	10	NOD	NOD	NNP
cord-275730-650sjwyy	81	11	mice	mouse	NNS
cord-275730-650sjwyy	81	12	with	with	IN
cord-275730-650sjwyy	81	13	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	81	14	delayed	delay	VBD
cord-275730-650sjwyy	81	15	the	the	DT
cord-275730-650sjwyy	81	16	type	type	NN
cord-275730-650sjwyy	82	1	I	-PRON-	PRP
cord-275730-650sjwyy	82	2	diabetes	diabete	VBZ
cord-275730-650sjwyy	82	3	(	(	-LRB-
cord-275730-650sjwyy	82	4	T1D	t1d	LS
cord-275730-650sjwyy	82	5	)	)	-RRB-
cord-275730-650sjwyy	82	6	onset	onset	NN
cord-275730-650sjwyy	82	7	[	[	-LRB-
cord-275730-650sjwyy	82	8	47	47	CD
cord-275730-650sjwyy	82	9	]	]	-RRB-
cord-275730-650sjwyy	82	10	that	that	WDT
cord-275730-650sjwyy	82	11	depends	depend	VBZ
cord-275730-650sjwyy	82	12	on	on	IN
cord-275730-650sjwyy	82	13	type	type	NN
cord-275730-650sjwyy	82	14	I	-PRON-	PRP
cord-275730-650sjwyy	82	15	IFNs	ifns	VBP
cord-275730-650sjwyy	82	16	.	.	.
cord-275730-650sjwyy	83	1	Thus	thus	RB
cord-275730-650sjwyy	83	2	,	,	,
cord-275730-650sjwyy	83	3	CDN	CDN	NNP
cord-275730-650sjwyy	83	4	may	may	MD
cord-275730-650sjwyy	83	5	be	be	VB
cord-275730-650sjwyy	83	6	used	use	VBN
cord-275730-650sjwyy	83	7	as	as	IN
cord-275730-650sjwyy	83	8	immune	immune	JJ
cord-275730-650sjwyy	83	9	-	-	HYPH
cord-275730-650sjwyy	83	10	modulatory	modulatory	JJ
cord-275730-650sjwyy	83	11	drugs	drug	NNS
cord-275730-650sjwyy	83	12	as	as	RB
cord-275730-650sjwyy	83	13	well	well	RB
cord-275730-650sjwyy	83	14	.	.	.
cord-275730-650sjwyy	84	1	IFNβ	IFNβ	NNP
cord-275730-650sjwyy	84	2	(	(	-LRB-
cord-275730-650sjwyy	84	3	Avonex	Avonex	NNP
cord-275730-650sjwyy	84	4	®	®	POS
cord-275730-650sjwyy	84	5	,	,	,
cord-275730-650sjwyy	84	6	Biogen	Biogen	NNP
cord-275730-650sjwyy	84	7	,	,	,
cord-275730-650sjwyy	84	8	MA	MA	NNP
cord-275730-650sjwyy	84	9	,	,	,
cord-275730-650sjwyy	84	10	USA	USA	NNP
cord-275730-650sjwyy	84	11	;	;	:
cord-275730-650sjwyy	85	1	Rebif	Rebif	NNP
cord-275730-650sjwyy	85	2	®	®	NNP
cord-275730-650sjwyy	85	3	,	,	,
cord-275730-650sjwyy	85	4	Merck	Merck	NNP
cord-275730-650sjwyy	85	5	,	,	,
cord-275730-650sjwyy	85	6	Darmstadt	Darmstadt	NNP
cord-275730-650sjwyy	85	7	,	,	,
cord-275730-650sjwyy	85	8	Germany	Germany	NNP
cord-275730-650sjwyy	85	9	)	)	-RRB-
cord-275730-650sjwyy	85	10	has	have	VBZ
cord-275730-650sjwyy	85	11	been	be	VBN
cord-275730-650sjwyy	85	12	used	use	VBN
cord-275730-650sjwyy	85	13	to	to	TO
cord-275730-650sjwyy	85	14	treat	treat	VB
cord-275730-650sjwyy	85	15	Multiple	multiple	JJ
cord-275730-650sjwyy	85	16	Sclerosis	Sclerosis	NNP
cord-275730-650sjwyy	85	17	for	for	IN
cord-275730-650sjwyy	85	18	over	over	IN
cord-275730-650sjwyy	85	19	20	20	CD
cord-275730-650sjwyy	85	20	years	year	NNS
cord-275730-650sjwyy	85	21	.	.	.
cord-275730-650sjwyy	86	1	However	however	RB
cord-275730-650sjwyy	86	2	,	,	,
cord-275730-650sjwyy	86	3	the	the	DT
cord-275730-650sjwyy	86	4	in	in	IN
cord-275730-650sjwyy	86	5	vivo	vivo	NN
cord-275730-650sjwyy	86	6	mechanism	mechanism	NN
cord-275730-650sjwyy	86	7	of	of	IN
cord-275730-650sjwyy	86	8	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	86	9	-	-	HYPH
cord-275730-650sjwyy	86	10	induced	induce	VBN
cord-275730-650sjwyy	86	11	tolerance	tolerance	NN
cord-275730-650sjwyy	86	12	and	and	CC
cord-275730-650sjwyy	86	13	targeted	target	VBN
cord-275730-650sjwyy	86	14	cell	cell	NN
cord-275730-650sjwyy	86	15	population	population	NN
cord-275730-650sjwyy	86	16	remain	remain	VBP
cord-275730-650sjwyy	86	17	unknown	unknown	JJ
cord-275730-650sjwyy	86	18	[	[	-LRB-
cord-275730-650sjwyy	86	19	48	48	CD
cord-275730-650sjwyy	86	20	]	]	-RRB-
cord-275730-650sjwyy	86	21	.	.	.
cord-275730-650sjwyy	87	1	CDN	CDN	NNP
cord-275730-650sjwyy	87	2	-	-	HYPH
cord-275730-650sjwyy	87	3	induced	induce	VBN
cord-275730-650sjwyy	87	4	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	87	5	may	may	MD
cord-275730-650sjwyy	87	6	have	have	VB
cord-275730-650sjwyy	87	7	a	a	DT
cord-275730-650sjwyy	87	8	similar	similar	JJ
cord-275730-650sjwyy	87	9	tolerance	tolerance	NN
cord-275730-650sjwyy	87	10	genetic	genetic	JJ
cord-275730-650sjwyy	87	11	effect	effect	NN
cord-275730-650sjwyy	87	12	in	in	IN
cord-275730-650sjwyy	87	13	vivo	vivo	NN
cord-275730-650sjwyy	87	14	,	,	,
cord-275730-650sjwyy	87	15	particularly	particularly	RB
cord-275730-650sjwyy	87	16	if	if	IN
cord-275730-650sjwyy	87	17	CDNs	cdn	NNS
cord-275730-650sjwyy	87	18	are	be	VBP
cord-275730-650sjwyy	87	19	targeted	target	VBN
cord-275730-650sjwyy	87	20	to	to	IN
cord-275730-650sjwyy	87	21	the	the	DT
cord-275730-650sjwyy	87	22	tolerogenic	tolerogenic	NNP
cord-275730-650sjwyy	87	23	DCs	DCs	NNP
cord-275730-650sjwyy	87	24	in	in	IN
cord-275730-650sjwyy	87	25	vivo	vivo	NNP
cord-275730-650sjwyy	87	26	.	.	.
cord-275730-650sjwyy	88	1	Noteworthy	noteworthy	JJ
cord-275730-650sjwyy	88	2	,	,	,
cord-275730-650sjwyy	88	3	Mellor	Mellor	NNP
cord-275730-650sjwyy	88	4	's	's	POS
cord-275730-650sjwyy	88	5	group	group	NN
cord-275730-650sjwyy	88	6	found	find	VBD
cord-275730-650sjwyy	88	7	that	that	IN
cord-275730-650sjwyy	88	8	while	while	IN
cord-275730-650sjwyy	88	9	the	the	DT
cord-275730-650sjwyy	88	10	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	88	11	treatment	treatment	NN
cord-275730-650sjwyy	88	12	delayed	delay	VBD
cord-275730-650sjwyy	88	13	the	the	DT
cord-275730-650sjwyy	88	14	T1D	t1d	JJ
cord-275730-650sjwyy	88	15	onset	onset	NN
cord-275730-650sjwyy	88	16	in	in	IN
cord-275730-650sjwyy	88	17	nonobese	nonobese	JJ
cord-275730-650sjwyy	88	18	diabetic	diabetic	JJ
cord-275730-650sjwyy	88	19	(	(	-LRB-
cord-275730-650sjwyy	88	20	NOD	NOD	NNP
cord-275730-650sjwyy	88	21	)	)	-RRB-
cord-275730-650sjwyy	88	22	mice	mouse	NNS
cord-275730-650sjwyy	88	23	,	,	,
cord-275730-650sjwyy	88	24	the	the	DT
cord-275730-650sjwyy	88	25	CDG	CDG	NNP
cord-275730-650sjwyy	88	26	treatment	treatment	NN
cord-275730-650sjwyy	88	27	did	do	VBD
cord-275730-650sjwyy	88	28	not	not	RB
cord-275730-650sjwyy	88	29	[	[	-LRB-
cord-275730-650sjwyy	88	30	47	47	CD
cord-275730-650sjwyy	88	31	]	]	-RRB-
cord-275730-650sjwyy	88	32	.	.	.
cord-275730-650sjwyy	89	1	A	a	DT
cord-275730-650sjwyy	89	2	further	further	JJ
cord-275730-650sjwyy	89	3	analysis	analysis	NN
cord-275730-650sjwyy	89	4	showed	show	VBD
cord-275730-650sjwyy	89	5	that	that	IN
cord-275730-650sjwyy	89	6	CDG	CDG	NNP
cord-275730-650sjwyy	89	7	,	,	,
cord-275730-650sjwyy	89	8	unlike	unlike	IN
cord-275730-650sjwyy	89	9	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	89	10	,	,	,
cord-275730-650sjwyy	89	11	did	do	VBD
cord-275730-650sjwyy	89	12	not	not	RB
cord-275730-650sjwyy	89	13	generate	generate	VB
cord-275730-650sjwyy	89	14	type	type	NN
cord-275730-650sjwyy	89	15	I	-PRON-	PRP
cord-275730-650sjwyy	89	16	IFNs	ifns	VBP
cord-275730-650sjwyy	89	17	in	in	IN
cord-275730-650sjwyy	89	18	NOD	NOD	NNP
cord-275730-650sjwyy	89	19	mice	mouse	NNS
cord-275730-650sjwyy	89	20	,	,	,
cord-275730-650sjwyy	89	21	though	though	IN
cord-275730-650sjwyy	89	22	NOD	NOD	NNP
cord-275730-650sjwyy	89	23	mice	mouse	NNS
cord-275730-650sjwyy	89	24	still	still	RB
cord-275730-650sjwyy	89	25	produced	produce	VBD
cord-275730-650sjwyy	89	26	TNF	TNF	NNP
cord-275730-650sjwyy	89	27	in	in	IN
cord-275730-650sjwyy	89	28	response	response	NN
cord-275730-650sjwyy	89	29	to	to	IN
cord-275730-650sjwyy	89	30	CDG	CDG	NNP
cord-275730-650sjwyy	89	31	[	[	-LRB-
cord-275730-650sjwyy	89	32	47	47	CD
cord-275730-650sjwyy	89	33	]	]	-RRB-
cord-275730-650sjwyy	89	34	.	.	.
cord-275730-650sjwyy	90	1	Lastly	lastly	RB
cord-275730-650sjwyy	90	2	,	,	,
cord-275730-650sjwyy	90	3	they	-PRON-	PRP
cord-275730-650sjwyy	90	4	found	find	VBD
cord-275730-650sjwyy	90	5	that	that	IN
cord-275730-650sjwyy	90	6	the	the	DT
cord-275730-650sjwyy	90	7	NOD	NOD	NNP
cord-275730-650sjwyy	90	8	mice	mouse	NNS
cord-275730-650sjwyy	90	9	contain	contain	VBP
cord-275730-650sjwyy	90	10	an	an	DT
cord-275730-650sjwyy	90	11	N210D	N210D	NNP
cord-275730-650sjwyy	90	12	STING	sting	NN
cord-275730-650sjwyy	90	13	polymorphism	polymorphism	NN
cord-275730-650sjwyy	90	14	that	that	WDT
cord-275730-650sjwyy	90	15	may	may	MD
cord-275730-650sjwyy	90	16	explain	explain	VB
cord-275730-650sjwyy	90	17	differential	differential	JJ
cord-275730-650sjwyy	90	18	type	type	NN
cord-275730-650sjwyy	90	19	I	-PRON-	PRP
cord-275730-650sjwyy	90	20	IFNs	ifns	VBP
cord-275730-650sjwyy	90	21	responses	response	NNS
cord-275730-650sjwyy	90	22	by	by	IN
cord-275730-650sjwyy	90	23	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	90	24	and	and	CC
cord-275730-650sjwyy	90	25	CDG	CDG	NNP
cord-275730-650sjwyy	90	26	[	[	-LRB-
cord-275730-650sjwyy	90	27	47	47	CD
cord-275730-650sjwyy	90	28	]	]	-RRB-
cord-275730-650sjwyy	90	29	.	.	.
cord-275730-650sjwyy	91	1	Previous	previous	JJ
cord-275730-650sjwyy	91	2	studies	study	NNS
cord-275730-650sjwyy	91	3	had	have	VBD
cord-275730-650sjwyy	91	4	similar	similar	JJ
cord-275730-650sjwyy	91	5	findings	finding	NNS
cord-275730-650sjwyy	91	6	on	on	IN
cord-275730-650sjwyy	91	7	the	the	DT
cord-275730-650sjwyy	91	8	selectivity	selectivity	NN
cord-275730-650sjwyy	91	9	of	of	IN
cord-275730-650sjwyy	91	10	CDNs	cdn	NNS
cord-275730-650sjwyy	91	11	in	in	IN
cord-275730-650sjwyy	91	12	activating	activate	VBG
cord-275730-650sjwyy	91	13	STING	sting	NN
cord-275730-650sjwyy	91	14	variants	variant	NNS
cord-275730-650sjwyy	91	15	in	in	IN
cord-275730-650sjwyy	91	16	mice	mouse	NNS
cord-275730-650sjwyy	91	17	.	.	.
cord-275730-650sjwyy	92	1	The	the	DT
cord-275730-650sjwyy	92	2	R231A	R231A	NNPS
cord-275730-650sjwyy	92	3	[	[	-LRB-
cord-275730-650sjwyy	92	4	49	49	CD
cord-275730-650sjwyy	92	5	]	]	-RRB-
cord-275730-650sjwyy	92	6	or	or	CC
cord-275730-650sjwyy	92	7	R231H	R231H	NNP
cord-275730-650sjwyy	92	8	[	[	-LRB-
cord-275730-650sjwyy	92	9	50	50	CD
cord-275730-650sjwyy	92	10	]	]	-RRB-
cord-275730-650sjwyy	92	11	change	change	NN
cord-275730-650sjwyy	92	12	in	in	IN
cord-275730-650sjwyy	92	13	the	the	DT
cord-275730-650sjwyy	92	14	mouse	mouse	NN
cord-275730-650sjwyy	92	15	STING	sting	NN
cord-275730-650sjwyy	92	16	rendered	render	VBD
cord-275730-650sjwyy	92	17	the	the	DT
cord-275730-650sjwyy	92	18	variants	variant	NNS
cord-275730-650sjwyy	92	19	selectively	selectively	RB
cord-275730-650sjwyy	92	20	to	to	TO
cord-275730-650sjwyy	92	21	lose	lose	VB
cord-275730-650sjwyy	92	22	the	the	DT
cord-275730-650sjwyy	92	23	response	response	NN
cord-275730-650sjwyy	92	24	to	to	IN
cord-275730-650sjwyy	92	25	CDG	CDG	NNP
cord-275730-650sjwyy	92	26	but	but	CC
cord-275730-650sjwyy	92	27	not	not	RB
cord-275730-650sjwyy	92	28	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	92	29	.	.	.
cord-275730-650sjwyy	93	1	Notably	notably	RB
cord-275730-650sjwyy	93	2	,	,	,
cord-275730-650sjwyy	93	3	both	both	DT
cord-275730-650sjwyy	93	4	human	human	JJ
cord-275730-650sjwyy	93	5	and	and	CC
cord-275730-650sjwyy	93	6	mouse	mouse	NN
cord-275730-650sjwyy	93	7	STING	sting	NN
cord-275730-650sjwyy	93	8	genes	gene	NNS
cord-275730-650sjwyy	93	9	have	have	VBP
cord-275730-650sjwyy	93	10	the	the	DT
cord-275730-650sjwyy	93	11	N210	N210	NNP
cord-275730-650sjwyy	93	12	residue	residue	NN
cord-275730-650sjwyy	93	13	while	while	IN
cord-275730-650sjwyy	93	14	STING	sting	NN
cord-275730-650sjwyy	93	15	genes	gene	NNS
cord-275730-650sjwyy	93	16	from	from	IN
cord-275730-650sjwyy	93	17	the	the	DT
cord-275730-650sjwyy	93	18	rat	rat	NN
cord-275730-650sjwyy	93	19	,	,	,
cord-275730-650sjwyy	93	20	pig	pig	NN
cord-275730-650sjwyy	93	21	,	,	,
cord-275730-650sjwyy	93	22	cat	cat	NN
cord-275730-650sjwyy	93	23	,	,	,
cord-275730-650sjwyy	93	24	dog	dog	NN
cord-275730-650sjwyy	93	25	,	,	,
cord-275730-650sjwyy	93	26	ferret	ferret	NN
cord-275730-650sjwyy	93	27	,	,	,
cord-275730-650sjwyy	93	28	and	and	CC
cord-275730-650sjwyy	93	29	hamster	hamster	NN
cord-275730-650sjwyy	93	30	have	have	VBP
cord-275730-650sjwyy	93	31	the	the	DT
cord-275730-650sjwyy	93	32	D210	D210	NNP
cord-275730-650sjwyy	93	33	residue	residue	NN
cord-275730-650sjwyy	93	34	.	.	.
cord-275730-650sjwyy	94	1	CDG	CDG	NNP
cord-275730-650sjwyy	94	2	may	may	MD
cord-275730-650sjwyy	94	3	lose	lose	VB
cord-275730-650sjwyy	94	4	its	-PRON-	PRP$
cord-275730-650sjwyy	94	5	type	type	NN
cord-275730-650sjwyy	95	1	I	-PRON-	PRP
cord-275730-650sjwyy	95	2	IFNs	ifns	NN
cord-275730-650sjwyy	95	3	-	-	HYPH
cord-275730-650sjwyy	95	4	dependent	dependent	JJ
cord-275730-650sjwyy	95	5	anti	anti	JJ
cord-275730-650sjwyy	95	6	-	-	JJ
cord-275730-650sjwyy	95	7	tumor	tumor	JJ
cord-275730-650sjwyy	95	8	and	and	CC
cord-275730-650sjwyy	95	9	tolerance	tolerance	NN
cord-275730-650sjwyy	95	10	-	-	HYPH
cord-275730-650sjwyy	95	11	inducing	induce	VBG
cord-275730-650sjwyy	95	12	function	function	NN
cord-275730-650sjwyy	95	13	in	in	IN
cord-275730-650sjwyy	95	14	these	these	DT
cord-275730-650sjwyy	95	15	model	model	NN
cord-275730-650sjwyy	95	16	organisms	organism	NNS
cord-275730-650sjwyy	95	17	.	.	.
cord-275730-650sjwyy	96	1	CDNs	CDNs	NNP
cord-275730-650sjwyy	96	2	carry	carry	VBP
cord-275730-650sjwyy	96	3	negative	negative	JJ
cord-275730-650sjwyy	96	4	charges	charge	NNS
cord-275730-650sjwyy	96	5	that	that	WDT
cord-275730-650sjwyy	96	6	may	may	MD
cord-275730-650sjwyy	96	7	prevent	prevent	VB
cord-275730-650sjwyy	96	8	them	-PRON-	PRP
cord-275730-650sjwyy	96	9	from	from	IN
cord-275730-650sjwyy	96	10	crossing	cross	VBG
cord-275730-650sjwyy	96	11	the	the	DT
cord-275730-650sjwyy	96	12	plasma	plasma	NN
cord-275730-650sjwyy	96	13	membrane	membrane	NN
cord-275730-650sjwyy	96	14	to	to	TO
cord-275730-650sjwyy	96	15	activate	activate	VB
cord-275730-650sjwyy	96	16	STING	sting	NN
cord-275730-650sjwyy	96	17	in	in	IN
cord-275730-650sjwyy	96	18	the	the	DT
cord-275730-650sjwyy	96	19	cytosol	cytosol	NN
cord-275730-650sjwyy	96	20	.	.	.
cord-275730-650sjwyy	97	1	Indeed	indeed	RB
cord-275730-650sjwyy	97	2	,	,	,
cord-275730-650sjwyy	97	3	in	in	IN
cord-275730-650sjwyy	97	4	vitro	vitro	FW
cord-275730-650sjwyy	97	5	cell	cell	NN
cord-275730-650sjwyy	97	6	activation	activation	NN
cord-275730-650sjwyy	97	7	by	by	IN
cord-275730-650sjwyy	97	8	CDNs	CDNs	NNP
cord-275730-650sjwyy	97	9	requires	require	VBZ
cord-275730-650sjwyy	97	10	transfection	transfection	NN
cord-275730-650sjwyy	97	11	reagents	reagent	NNS
cord-275730-650sjwyy	97	12	or	or	CC
cord-275730-650sjwyy	97	13	membrane	membrane	NN
cord-275730-650sjwyy	97	14	permeabilization	permeabilization	NN
cord-275730-650sjwyy	97	15	to	to	TO
cord-275730-650sjwyy	97	16	deliver	deliver	VB
cord-275730-650sjwyy	97	17	CDNs	cdn	NNS
cord-275730-650sjwyy	97	18	into	into	IN
cord-275730-650sjwyy	97	19	the	the	DT
cord-275730-650sjwyy	97	20	cytosol	cytosol	NN
cord-275730-650sjwyy	97	21	.	.	.
cord-275730-650sjwyy	98	1	The	the	DT
cord-275730-650sjwyy	98	2	only	only	JJ
cord-275730-650sjwyy	98	3	CDNs	cdn	NNS
cord-275730-650sjwyy	98	4	that	that	WDT
cord-275730-650sjwyy	98	5	directly	directly	RB
cord-275730-650sjwyy	98	6	activate	activate	VBP
cord-275730-650sjwyy	98	7	cells	cell	NNS
cord-275730-650sjwyy	98	8	in	in	IN
cord-275730-650sjwyy	98	9	culture	culture	NN
cord-275730-650sjwyy	98	10	without	without	IN
cord-275730-650sjwyy	98	11	the	the	DT
cord-275730-650sjwyy	98	12	need	need	NN
cord-275730-650sjwyy	98	13	for	for	IN
cord-275730-650sjwyy	98	14	membrane	membrane	NN
cord-275730-650sjwyy	98	15	permeabilization	permeabilization	NN
cord-275730-650sjwyy	98	16	is	be	VBZ
cord-275730-650sjwyy	98	17	the	the	DT
cord-275730-650sjwyy	98	18	synthetic	synthetic	JJ
cord-275730-650sjwyy	98	19	CDN	CDN	NNP
cord-275730-650sjwyy	98	20	RpRpSS	RpRpSS	NNP
cord-275730-650sjwyy	98	21	-	-	HYPH
cord-275730-650sjwyy	98	22	CDA	CDA	NNP
cord-275730-650sjwyy	98	23	[	[	-LRB-
cord-275730-650sjwyy	98	24	51	51	CD
cord-275730-650sjwyy	98	25	]	]	-RRB-
cord-275730-650sjwyy	98	26	.	.	.
cord-275730-650sjwyy	99	1	In	in	IN
cord-275730-650sjwyy	99	2	vivo	vivo	NNP
cord-275730-650sjwyy	99	3	,	,	,
cord-275730-650sjwyy	99	4	i.n	i.n	NNP
cord-275730-650sjwyy	99	5	.	.	NNP
cord-275730-650sjwyy	99	6	,	,	,
cord-275730-650sjwyy	99	7	i.p	i.p	NNP
cord-275730-650sjwyy	99	8	.	.	NNP
cord-275730-650sjwyy	99	9	,	,	,
cord-275730-650sjwyy	99	10	s.c	s.c	NNP
cord-275730-650sjwyy	99	11	.	.	NNP
cord-275730-650sjwyy	99	12	administration	administration	NNP
cord-275730-650sjwyy	99	13	of	of	IN
cord-275730-650sjwyy	99	14	CDNs	CDNs	NNP
cord-275730-650sjwyy	99	15	can	can	MD
cord-275730-650sjwyy	99	16	all	all	DT
cord-275730-650sjwyy	99	17	induce	induce	VB
cord-275730-650sjwyy	99	18	vaccine	vaccine	NN
cord-275730-650sjwyy	99	19	responses	response	NNS
cord-275730-650sjwyy	99	20	in	in	IN
cord-275730-650sjwyy	99	21	mice	mouse	NNS
cord-275730-650sjwyy	99	22	without	without	IN
cord-275730-650sjwyy	99	23	the	the	DT
cord-275730-650sjwyy	99	24	need	need	NN
cord-275730-650sjwyy	99	25	for	for	IN
cord-275730-650sjwyy	99	26	transfection	transfection	NN
cord-275730-650sjwyy	99	27	reagents	reagent	NNS
cord-275730-650sjwyy	99	28	[	[	-LRB-
cord-275730-650sjwyy	99	29	8	8	CD
cord-275730-650sjwyy	99	30	,	,	,
cord-275730-650sjwyy	99	31	9	9	CD
cord-275730-650sjwyy	99	32	,	,	,
cord-275730-650sjwyy	99	33	15	15	CD
cord-275730-650sjwyy	99	34	,	,	,
cord-275730-650sjwyy	99	35	31	31	CD
cord-275730-650sjwyy	99	36	,	,	,
cord-275730-650sjwyy	99	37	52	52	CD
cord-275730-650sjwyy	99	38	]	]	-RRB-
cord-275730-650sjwyy	99	39	.	.	.
cord-275730-650sjwyy	100	1	These	these	DT
cord-275730-650sjwyy	100	2	CDNs	cdn	NNS
cord-275730-650sjwyy	100	3	are	be	VBP
cord-275730-650sjwyy	100	4	likely	likely	RB
cord-275730-650sjwyy	100	5	taken	take	VBN
cord-275730-650sjwyy	100	6	up	up	RP
cord-275730-650sjwyy	100	7	by	by	IN
cord-275730-650sjwyy	100	8	DCs	dc	NNS
cord-275730-650sjwyy	100	9	and	and	CC
cord-275730-650sjwyy	100	10	phagocytes	phagocyte	NNS
cord-275730-650sjwyy	100	11	directly	directly	RB
cord-275730-650sjwyy	100	12	by	by	IN
cord-275730-650sjwyy	100	13	pinocytosis	pinocytosis	NN
cord-275730-650sjwyy	100	14	or	or	CC
cord-275730-650sjwyy	100	15	phagocytosis	phagocytosis	NN
cord-275730-650sjwyy	100	16	[	[	-LRB-
cord-275730-650sjwyy	100	17	43	43	CD
cord-275730-650sjwyy	100	18	]	]	-RRB-
cord-275730-650sjwyy	100	19	.	.	.
cord-275730-650sjwyy	101	1	With	with	IN
cord-275730-650sjwyy	101	2	the	the	DT
cord-275730-650sjwyy	101	3	advent	advent	NN
cord-275730-650sjwyy	101	4	of	of	IN
cord-275730-650sjwyy	101	5	nanotechnology	nanotechnology	NN
cord-275730-650sjwyy	101	6	,	,	,
cord-275730-650sjwyy	101	7	nanoparticle	nanoparticle	NN
cord-275730-650sjwyy	101	8	,	,	,
cord-275730-650sjwyy	101	9	and	and	CC
cord-275730-650sjwyy	101	10	microparticle	microparticle	NNP
cord-275730-650sjwyy	101	11	mediated	mediate	VBD
cord-275730-650sjwyy	101	12	delivery	delivery	NN
cord-275730-650sjwyy	101	13	vehicle	vehicle	NN
cord-275730-650sjwyy	101	14	such	such	JJ
cord-275730-650sjwyy	101	15	as	as	IN
cord-275730-650sjwyy	101	16	liposomes	liposome	NNS
cord-275730-650sjwyy	101	17	,	,	,
cord-275730-650sjwyy	101	18	emulsions	emulsion	NNS
cord-275730-650sjwyy	101	19	,	,	,
cord-275730-650sjwyy	101	20	virus	virus	NN
cord-275730-650sjwyy	101	21	-	-	HYPH
cord-275730-650sjwyy	101	22	like	like	JJ
cord-275730-650sjwyy	101	23	particles	particle	NNS
cord-275730-650sjwyy	101	24	,	,	,
cord-275730-650sjwyy	101	25	biodegradable	biodegradable	JJ
cord-275730-650sjwyy	101	26	polymers	polymer	NNS
cord-275730-650sjwyy	101	27	,	,	,
cord-275730-650sjwyy	101	28	immune	immune	NN
cord-275730-650sjwyy	101	29	-	-	HYPH
cord-275730-650sjwyy	101	30	stimulating	stimulate	VBG
cord-275730-650sjwyy	101	31	complexes	complex	NNS
cord-275730-650sjwyy	101	32	(	(	-LRB-
cord-275730-650sjwyy	101	33	ISCOM	ISCOM	NNP
cord-275730-650sjwyy	101	34	)	)	-RRB-
cord-275730-650sjwyy	101	35	have	have	VBP
cord-275730-650sjwyy	101	36	received	receive	VBN
cord-275730-650sjwyy	101	37	tremendous	tremendous	JJ
cord-275730-650sjwyy	101	38	attention	attention	NN
cord-275730-650sjwyy	101	39	.	.	.
cord-275730-650sjwyy	102	1	These	these	DT
cord-275730-650sjwyy	102	2	new	new	JJ
cord-275730-650sjwyy	102	3	delivery	delivery	NN
cord-275730-650sjwyy	102	4	methods	method	NNS
cord-275730-650sjwyy	102	5	provide	provide	VBP
cord-275730-650sjwyy	102	6	a	a	DT
cord-275730-650sjwyy	102	7	sustained	sustained	JJ
cord-275730-650sjwyy	102	8	release	release	NN
cord-275730-650sjwyy	102	9	of	of	IN
cord-275730-650sjwyy	102	10	the	the	DT
cord-275730-650sjwyy	102	11	cargo	cargo	NN
cord-275730-650sjwyy	102	12	from	from	IN
cord-275730-650sjwyy	102	13	the	the	DT
cord-275730-650sjwyy	102	14	matrix	matrix	NN
cord-275730-650sjwyy	102	15	and	and	CC
cord-275730-650sjwyy	102	16	improve	improve	VB
cord-275730-650sjwyy	102	17	bioavailability	bioavailability	NN
cord-275730-650sjwyy	102	18	and	and	CC
cord-275730-650sjwyy	102	19	dosing	dosing	NN
cord-275730-650sjwyy	102	20	frequency	frequency	NN
cord-275730-650sjwyy	102	21	[	[	-LRB-
cord-275730-650sjwyy	102	22	53	53	CD
cord-275730-650sjwyy	102	23	,	,	,
cord-275730-650sjwyy	102	24	54	54	CD
cord-275730-650sjwyy	102	25	]	]	-RRB-
cord-275730-650sjwyy	102	26	.	.	.
cord-275730-650sjwyy	103	1	Thus	thus	RB
cord-275730-650sjwyy	103	2	,	,	,
cord-275730-650sjwyy	103	3	nanoparticle	nanoparticle	NN
cord-275730-650sjwyy	103	4	or	or	CC
cord-275730-650sjwyy	103	5	microparticle	microparticle	NNP
cord-275730-650sjwyy	103	6	encapsulated	encapsulate	VBD
cord-275730-650sjwyy	103	7	CDNs	CDNs	NNP
cord-275730-650sjwyy	103	8	have	have	VBP
cord-275730-650sjwyy	103	9	been	be	VBN
cord-275730-650sjwyy	103	10	fabricated	fabricate	VBN
cord-275730-650sjwyy	103	11	and	and	CC
cord-275730-650sjwyy	103	12	studied	study	VBN
cord-275730-650sjwyy	103	13	as	as	IN
cord-275730-650sjwyy	103	14	an	an	DT
cord-275730-650sjwyy	103	15	alternative	alternative	JJ
cord-275730-650sjwyy	103	16	delivery	delivery	NN
cord-275730-650sjwyy	103	17	approach	approach	NN
cord-275730-650sjwyy	103	18	of	of	IN
cord-275730-650sjwyy	103	19	CDNs	CDNs	NNP
cord-275730-650sjwyy	103	20	in	in	IN
cord-275730-650sjwyy	103	21	vivo	vivo	NNP
cord-275730-650sjwyy	103	22	[	[	-LRB-
cord-275730-650sjwyy	103	23	10	10	CD
cord-275730-650sjwyy	103	24	,	,	,
cord-275730-650sjwyy	103	25	[	[	-LRB-
cord-275730-650sjwyy	103	26	55	55	CD
cord-275730-650sjwyy	103	27	]	]	-RRB-
cord-275730-650sjwyy	104	1	[	[	-LRB-
cord-275730-650sjwyy	104	2	56	56	CD
cord-275730-650sjwyy	104	3	]	]	-RRB-
cord-275730-650sjwyy	104	4	[	[	-LRB-
cord-275730-650sjwyy	104	5	57	57	CD
cord-275730-650sjwyy	104	6	]	]	-RRB-
cord-275730-650sjwyy	105	1	(	(	-LRB-
cord-275730-650sjwyy	105	2	Table	table	NN
cord-275730-650sjwyy	105	3	2	2	CD
cord-275730-650sjwyy	105	4	)	)	-RRB-
cord-275730-650sjwyy	105	5	.	.	.
cord-275730-650sjwyy	106	1	Table	table	NN
cord-275730-650sjwyy	106	2	2	2	CD
cord-275730-650sjwyy	106	3	.	.	.
cord-275730-650sjwyy	107	1	Cyclic	cyclic	JJ
cord-275730-650sjwyy	107	2	dinucleotide	dinucleotide	NN
cord-275730-650sjwyy	107	3	as	as	IN
cord-275730-650sjwyy	107	4	vaccine	vaccine	NN
cord-275730-650sjwyy	107	5	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	107	6	.	.	.
cord-275730-650sjwyy	108	1	RpRp	RpRp	NNP
cord-275730-650sjwyy	108	2	-	-	HYPH
cord-275730-650sjwyy	108	3	SS	SS	NNP
cord-275730-650sjwyy	108	4	-	-	HYPH
cord-275730-650sjwyy	108	5	CDG	CDG	NNP
cord-275730-650sjwyy	108	6	/	/	SYM
cord-275730-650sjwyy	108	7	ML	ML	NNP
cord-275730-650sjwyy	108	8	-	-	HYPH
cord-275730-650sjwyy	108	9	RpRp	RpRp	NNP
cord-275730-650sjwyy	108	10	-	-	HYPH
cord-275730-650sjwyy	108	11	SS	SS	NNP
cord-275730-650sjwyy	108	12	-	-	HYPH
cord-275730-650sjwyy	108	13	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	109	1	in	in	IN
cord-275730-650sjwyy	109	2	Addvax	Addvax	NNP
cord-275730-650sjwyy	109	3	[	[	-LRB-
cord-275730-650sjwyy	109	4	Squalene	Squalene	NNP
cord-275730-650sjwyy	109	5	based	base	VBN
cord-275730-650sjwyy	109	6	oil	oil	NN
cord-275730-650sjwyy	109	7	-	-	HYPH
cord-275730-650sjwyy	109	8	in	in	IN
cord-275730-650sjwyy	109	9	-	-	HYPH
cord-275730-650sjwyy	109	10	water	water	NN
cord-275730-650sjwyy	109	11	nano	nano	NN
cord-275730-650sjwyy	109	12	emulsion	emulsion	NN
cord-275730-650sjwyy	109	13	]	]	-RRB-
cord-275730-650sjwyy	110	1	(	(	-LRB-
cord-275730-650sjwyy	110	2	s.c	s.c	NNP
cord-275730-650sjwyy	110	3	.	.	NNP
cord-275730-650sjwyy	110	4	)	)	-RRB-
cord-275730-650sjwyy	110	5	or	or	CC
cord-275730-650sjwyy	110	6	in	in	IN
cord-275730-650sjwyy	110	7	PBS	PBS	NNP
cord-275730-650sjwyy	110	8	(	(	-LRB-
cord-275730-650sjwyy	110	9	i.n	i.n	NNP
cord-275730-650sjwyy	110	10	.	.	NNP
cord-275730-650sjwyy	110	11	)	)	-RRB-
cord-275730-650sjwyy	110	12	[	[	-LRB-
cord-275730-650sjwyy	110	13	11	11	CD
cord-275730-650sjwyy	110	14	]	]	-RRB-
cord-275730-650sjwyy	110	15	Th1	th1	NN
cord-275730-650sjwyy	110	16	,	,	,
cord-275730-650sjwyy	110	17	Th17	Th17	NNP
cord-275730-650sjwyy	110	18	responses	response	NNS
cord-275730-650sjwyy	110	19	;	;	:
cord-275730-650sjwyy	110	20	protection	protection	NN
cord-275730-650sjwyy	110	21	against	against	IN
cord-275730-650sjwyy	110	22	Mtb	Mtb	NNP
cord-275730-650sjwyy	110	23	infection	infection	NN
cord-275730-650sjwyy	110	24	cGAMP	cgamp	NN
cord-275730-650sjwyy	110	25	in	in	IN
cord-275730-650sjwyy	110	26	pulmonary	pulmonary	JJ
cord-275730-650sjwyy	110	27	surfactant	surfactant	NN
cord-275730-650sjwyy	110	28	mimicking	mimic	VBG
cord-275730-650sjwyy	110	29	liposome	liposome	NN
cord-275730-650sjwyy	110	30	(	(	-LRB-
cord-275730-650sjwyy	110	31	i.n	i.n	NNP
cord-275730-650sjwyy	110	32	.	.	NNP
cord-275730-650sjwyy	110	33	)	)	-RRB-
cord-275730-650sjwyy	111	1	[	[	-LRB-
cord-275730-650sjwyy	111	2	10	10	CD
cord-275730-650sjwyy	111	3	]	]	-RRB-
cord-275730-650sjwyy	111	4	CD8	CD8	NNP
cord-275730-650sjwyy	111	5	+	+	CC
cord-275730-650sjwyy	111	6	T	T	NNP
cord-275730-650sjwyy	111	7	cell	cell	NN
cord-275730-650sjwyy	111	8	response	response	NN
cord-275730-650sjwyy	111	9	;	;	:
cord-275730-650sjwyy	111	10	100	100	CD
cord-275730-650sjwyy	111	11	%	%	NN
cord-275730-650sjwyy	111	12	protection	protection	NN
cord-275730-650sjwyy	111	13	against	against	IN
cord-275730-650sjwyy	111	14	a	a	DT
cord-275730-650sjwyy	111	15	10LD	10ld	CD
cord-275730-650sjwyy	111	16	50	50	CD
cord-275730-650sjwyy	111	17	virulent	virulent	JJ
cord-275730-650sjwyy	111	18	strain	strain	NN
cord-275730-650sjwyy	111	19	of	of	IN
cord-275730-650sjwyy	111	20	CA09	CA09	NNP
cord-275730-650sjwyy	111	21	H1N1	H1N1	NNP
cord-275730-650sjwyy	111	22	CDG	CDG	NNP
cord-275730-650sjwyy	111	23	in	in	IN
cord-275730-650sjwyy	111	24	PEG	PEG	NNP
cord-275730-650sjwyy	111	25	lipid	lipid	NN
cord-275730-650sjwyy	111	26	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	111	27	(	(	-LRB-
cord-275730-650sjwyy	111	28	s.c	s.c	NNP
cord-275730-650sjwyy	111	29	.	.	NNP
cord-275730-650sjwyy	111	30	)	)	-RRB-
cord-275730-650sjwyy	112	1	[	[	-LRB-
cord-275730-650sjwyy	112	2	58	58	CD
cord-275730-650sjwyy	112	3	]	]	-RRB-
cord-275730-650sjwyy	113	1	Tfh	Tfh	NNP
cord-275730-650sjwyy	113	2	and	and	CC
cord-275730-650sjwyy	113	3	GC	GC	NNP
cord-275730-650sjwyy	113	4	B	B	NNP
cord-275730-650sjwyy	113	5	cell	cell	NN
cord-275730-650sjwyy	113	6	induction	induction	NN
cord-275730-650sjwyy	113	7	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	113	8	in	in	IN
cord-275730-650sjwyy	113	9	ultra	ultra	JJ
cord-275730-650sjwyy	113	10	-	-	JJ
cord-275730-650sjwyy	113	11	pH	ph	JJ
cord-275730-650sjwyy	113	12	sensitive	sensitive	JJ
cord-275730-650sjwyy	113	13	nanoparticle	nanoparticle	NN
cord-275730-650sjwyy	113	14	ex	ex	NN
cord-275730-650sjwyy	113	15	vivo	vivo	NNP
cord-275730-650sjwyy	113	16	human	human	JJ
cord-275730-650sjwyy	113	17	PBMC	PBMC	NNP
cord-275730-650sjwyy	113	18	[	[	-LRB-
cord-275730-650sjwyy	113	19	59	59	CD
cord-275730-650sjwyy	113	20	]	]	-RRB-
cord-275730-650sjwyy	114	1	IL-6	IL-6	NNP
cord-275730-650sjwyy	114	2	,	,	,
cord-275730-650sjwyy	114	3	IL-8	IL-8	NNP
cord-275730-650sjwyy	114	4	,	,	,
cord-275730-650sjwyy	114	5	G	G	NNP
cord-275730-650sjwyy	114	6	-	-	HYPH
cord-275730-650sjwyy	114	7	CSF	CSF	NNP
cord-275730-650sjwyy	114	8	,	,	,
cord-275730-650sjwyy	114	9	TNF	TNF	NNP
cord-275730-650sjwyy	114	10	-	-	HYPH
cord-275730-650sjwyy	114	11	a	a	NNP
cord-275730-650sjwyy	114	12	,	,	,
cord-275730-650sjwyy	114	13	type	type	NN
cord-275730-650sjwyy	114	14	I	-PRON-	PRP
cord-275730-650sjwyy	114	15	IFNs	ifn	NNS
cord-275730-650sjwyy	114	16	,	,	,
cord-275730-650sjwyy	114	17	MIP-1α	MIP-1α	NNP
cord-275730-650sjwyy	114	18	production	production	NN
cord-275730-650sjwyy	114	19	from	from	IN
cord-275730-650sjwyy	114	20	HIV	HIV	NNP
cord-275730-650sjwyy	114	21	infected	infect	VBD
cord-275730-650sjwyy	114	22	PBMC	PBMC	NNP
cord-275730-650sjwyy	114	23	,	,	,
cord-275730-650sjwyy	114	24	and	and	CC
cord-275730-650sjwyy	114	25	inhibited	inhibit	VBN
cord-275730-650sjwyy	114	26	HIV	HIV	NNP
cord-275730-650sjwyy	115	1	I	-PRON-	PRP
cord-275730-650sjwyy	115	2	replication	replication	VBP
cord-275730-650sjwyy	115	3	CDG	CDG	NNP
cord-275730-650sjwyy	115	4	in	in	IN
cord-275730-650sjwyy	115	5	PBS	PBS	NNP
cord-275730-650sjwyy	115	6	(	(	-LRB-
cord-275730-650sjwyy	115	7	i.n	i.n	NNP
cord-275730-650sjwyy	115	8	.	.	NNP
cord-275730-650sjwyy	115	9	,	,	,
cord-275730-650sjwyy	115	10	i.m	i.m	NNP
cord-275730-650sjwyy	115	11	.	.	NNP
cord-275730-650sjwyy	115	12	s.c	s.c	NNP
cord-275730-650sjwyy	115	13	.	.	NNP
cord-275730-650sjwyy	115	14	,	,	,
cord-275730-650sjwyy	115	15	i.p	i.p	NNP
cord-275730-650sjwyy	115	16	.	.	NNP
cord-275730-650sjwyy	115	17	)	)	-RRB-
cord-275730-650sjwyy	115	18	[	[	-LRB-
cord-275730-650sjwyy	115	19	4	4	CD
cord-275730-650sjwyy	115	20	,	,	,
cord-275730-650sjwyy	115	21	5	5	CD
cord-275730-650sjwyy	115	22	,	,	,
cord-275730-650sjwyy	115	23	8	8	CD
cord-275730-650sjwyy	115	24	,	,	,
cord-275730-650sjwyy	115	25	9	9	CD
cord-275730-650sjwyy	115	26	,	,	,
cord-275730-650sjwyy	115	27	13	13	CD
cord-275730-650sjwyy	115	28	,	,	,
cord-275730-650sjwyy	115	29	15	15	CD
cord-275730-650sjwyy	115	30	,	,	,
cord-275730-650sjwyy	115	31	43	43	CD
cord-275730-650sjwyy	115	32	]	]	-RRB-
cord-275730-650sjwyy	115	33	Systemic	systemic	JJ
cord-275730-650sjwyy	115	34	and	and	CC
cord-275730-650sjwyy	115	35	mucosal	mucosal	JJ
cord-275730-650sjwyy	115	36	humoral	humoral	JJ
cord-275730-650sjwyy	115	37	and	and	CC
cord-275730-650sjwyy	115	38	cellular	cellular	JJ
cord-275730-650sjwyy	115	39	immune	immune	JJ
cord-275730-650sjwyy	115	40	responses	response	NNS
cord-275730-650sjwyy	115	41	that	that	WDT
cord-275730-650sjwyy	115	42	protect	protect	VBP
cord-275730-650sjwyy	115	43	from	from	IN
cord-275730-650sjwyy	115	44	bacterial	bacterial	JJ
cord-275730-650sjwyy	115	45	infections	infection	NNS
cord-275730-650sjwyy	115	46	CDA	CDA	NNP
cord-275730-650sjwyy	115	47	with	with	IN
cord-275730-650sjwyy	115	48	alum	alum	NN
cord-275730-650sjwyy	115	49	(	(	-LRB-
cord-275730-650sjwyy	115	50	i.m	i.m	NNP
cord-275730-650sjwyy	115	51	.	.	.
cord-275730-650sjwyy	115	52	)	)	-RRB-
cord-275730-650sjwyy	116	1	or	or	CC
cord-275730-650sjwyy	116	2	in	in	IN
cord-275730-650sjwyy	116	3	PBS	PBS	NNP
cord-275730-650sjwyy	116	4	(	(	-LRB-
cord-275730-650sjwyy	116	5	s.c	s.c	NNP
cord-275730-650sjwyy	116	6	.	.	NNP
cord-275730-650sjwyy	116	7	or	or	CC
cord-275730-650sjwyy	116	8	i.n	i.n	NNP
cord-275730-650sjwyy	116	9	.	.	NNP
cord-275730-650sjwyy	116	10	)	)	-RRB-
cord-275730-650sjwyy	116	11	[	[	-LRB-
cord-275730-650sjwyy	116	12	7	7	CD
cord-275730-650sjwyy	116	13	,	,	,
cord-275730-650sjwyy	116	14	18	18	CD
cord-275730-650sjwyy	116	15	,	,	,
cord-275730-650sjwyy	116	16	31	31	CD
cord-275730-650sjwyy	116	17	]	]	-RRB-
cord-275730-650sjwyy	116	18	Balanced	balanced	JJ
cord-275730-650sjwyy	116	19	IgG1	igg1	NN
cord-275730-650sjwyy	116	20	and	and	CC
cord-275730-650sjwyy	116	21	IgG2a	IgG2a	NNP
cord-275730-650sjwyy	116	22	responses	response	NNS
cord-275730-650sjwyy	117	1	;	;	:
cord-275730-650sjwyy	117	2	Th1	Th1	NNP
cord-275730-650sjwyy	117	3	/	/	SYM
cord-275730-650sjwyy	117	4	Th2	Th2	NNP
cord-275730-650sjwyy	117	5	/	/	SYM
cord-275730-650sjwyy	117	6	Th17	th17	CD
cord-275730-650sjwyy	117	7	responses	response	NNS
cord-275730-650sjwyy	117	8	Table	Table	NNP
cord-275730-650sjwyy	117	9	2	2	CD
cord-275730-650sjwyy	117	10	.	.	.
cord-275730-650sjwyy	118	1	Cont	Cont	NNP
cord-275730-650sjwyy	118	2	.	.	.
cord-275730-650sjwyy	119	1	(	(	-LRB-
cord-275730-650sjwyy	119	2	STINGel	stingel	NN
cord-275730-650sjwyy	119	3	)	)	-RRB-
cord-275730-650sjwyy	119	4	Synthetic	Synthetic	NNP
cord-275730-650sjwyy	119	5	ML	ML	NNP
cord-275730-650sjwyy	119	6	-	-	HYPH
cord-275730-650sjwyy	119	7	RpRp	RpRp	NNP
cord-275730-650sjwyy	119	8	-	-	HYPH
cord-275730-650sjwyy	119	9	SS	SS	NNP
cord-275730-650sjwyy	119	10	-	-	HYPH
cord-275730-650sjwyy	119	11	CDA	CDA	NNP
cord-275730-650sjwyy	119	12	in	in	IN
cord-275730-650sjwyy	119	13	multidomain	multidomain	NN
cord-275730-650sjwyy	119	14	peptide	peptide	NN
cord-275730-650sjwyy	119	15	hydrogel	hydrogel	NN
cord-275730-650sjwyy	119	16	(	(	-LRB-
cord-275730-650sjwyy	119	17	s.c	s.c	NNP
cord-275730-650sjwyy	119	18	.	.	NNP
cord-275730-650sjwyy	119	19	)	)	-RRB-
cord-275730-650sjwyy	120	1	[	[	-LRB-
cord-275730-650sjwyy	120	2	60	60	CD
cord-275730-650sjwyy	120	3	]	]	-RRB-
cord-275730-650sjwyy	120	4	Slow	slow	JJ
cord-275730-650sjwyy	120	5	-	-	HYPH
cord-275730-650sjwyy	120	6	release	release	NN
cord-275730-650sjwyy	120	7	of	of	IN
cord-275730-650sjwyy	120	8	CDN	CDN	NNP
cord-275730-650sjwyy	120	9	and	and	CC
cord-275730-650sjwyy	120	10	highly	highly	RB
cord-275730-650sjwyy	120	11	effective	effective	JJ
cord-275730-650sjwyy	120	12	in	in	IN
cord-275730-650sjwyy	120	13	maintaining	maintain	VBG
cord-275730-650sjwyy	120	14	tumor	tumor	NN
cord-275730-650sjwyy	120	15	clearance	clearance	NN
cord-275730-650sjwyy	120	16	and	and	CC
cord-275730-650sjwyy	120	17	rejecting	reject	VBG
cord-275730-650sjwyy	120	18	tumor	tumor	NN
cord-275730-650sjwyy	120	19	growth	growth	NN
cord-275730-650sjwyy	120	20	and	and	CC
cord-275730-650sjwyy	120	21	provide	provide	VB
cord-275730-650sjwyy	120	22	durable	durable	JJ
cord-275730-650sjwyy	120	23	anti	anti	JJ
cord-275730-650sjwyy	120	24	-	-	JJ
cord-275730-650sjwyy	120	25	tumor	tumor	JJ
cord-275730-650sjwyy	120	26	immunity	immunity	NN
cord-275730-650sjwyy	120	27	CDG	CDG	NNP
cord-275730-650sjwyy	120	28	in	in	IN
cord-275730-650sjwyy	120	29	YSK05	YSK05	NNP
cord-275730-650sjwyy	120	30	liposome	liposome	NN
cord-275730-650sjwyy	120	31	(	(	-LRB-
cord-275730-650sjwyy	120	32	s.c	s.c	NNP
cord-275730-650sjwyy	120	33	.	.	.
cord-275730-650sjwyy	120	34	)	)	-RRB-
cord-275730-650sjwyy	121	1	[	[	-LRB-
cord-275730-650sjwyy	121	2	61	61	CD
cord-275730-650sjwyy	121	3	]	]	-RRB-
cord-275730-650sjwyy	121	4	Activation	Activation	NNP
cord-275730-650sjwyy	121	5	of	of	IN
cord-275730-650sjwyy	121	6	antigen	antigen	NN
cord-275730-650sjwyy	121	7	-	-	HYPH
cord-275730-650sjwyy	121	8	specific	specific	JJ
cord-275730-650sjwyy	121	9	CTL	CTL	NNP
cord-275730-650sjwyy	121	10	activity	activity	NN
cord-275730-650sjwyy	121	11	and	and	CC
cord-275730-650sjwyy	121	12	restrict	restrict	VB
cord-275730-650sjwyy	121	13	murine	murine	JJ
cord-275730-650sjwyy	121	14	tumor	tumor	NN
cord-275730-650sjwyy	121	15	growth	growth	NN
cord-275730-650sjwyy	121	16	completely	completely	RB
cord-275730-650sjwyy	121	17	ADU	ADU	NNP
cord-275730-650sjwyy	121	18	-	-	HYPH
cord-275730-650sjwyy	121	19	S100	S100	NNP
cord-275730-650sjwyy	122	1	(	(	-LRB-
cord-275730-650sjwyy	122	2	Synthetic	Synthetic	NNP
cord-275730-650sjwyy	122	3	ML	ML	NNP
cord-275730-650sjwyy	122	4	-	-	HYPH
cord-275730-650sjwyy	122	5	RpRp	RpRp	NNP
cord-275730-650sjwyy	122	6	-	-	HYPH
cord-275730-650sjwyy	122	7	SS	SS	NNP
cord-275730-650sjwyy	122	8	-	-	HYPH
cord-275730-650sjwyy	122	9	CDA	CDA	NNP
cord-275730-650sjwyy	122	10	)	)	-RRB-
cord-275730-650sjwyy	123	1	in	in	IN
cord-275730-650sjwyy	123	2	combination	combination	NN
cord-275730-650sjwyy	123	3	with	with	IN
cord-275730-650sjwyy	123	4	anti	anti	JJ
cord-275730-650sjwyy	123	5	-	-	JJ
cord-275730-650sjwyy	123	6	PD1	pd1	JJ
cord-275730-650sjwyy	123	7	or	or	CC
cord-275730-650sjwyy	123	8	anti	anti	NNS
cord-275730-650sjwyy	123	9	-	-	JJ
cord-275730-650sjwyy	123	10	CTLA4	ctla4	JJ
cord-275730-650sjwyy	123	11	antibody	antibody	NN
cord-275730-650sjwyy	123	12	(	(	-LRB-
cord-275730-650sjwyy	123	13	intratumoral	intratumoral	NNP
cord-275730-650sjwyy	123	14	)	)	-RRB-
cord-275730-650sjwyy	123	15	[	[	-LRB-
cord-275730-650sjwyy	123	16	62	62	CD
cord-275730-650sjwyy	123	17	]	]	-RRB-
cord-275730-650sjwyy	123	18	Low	low	JJ
cord-275730-650sjwyy	123	19	-	-	HYPH
cord-275730-650sjwyy	123	20	dosage	dosage	NN
cord-275730-650sjwyy	123	21	promotes	promote	VBZ
cord-275730-650sjwyy	123	22	local	local	JJ
cord-275730-650sjwyy	123	23	STING	sting	NN
cord-275730-650sjwyy	123	24	activation	activation	NN
cord-275730-650sjwyy	123	25	primarily	primarily	RB
cord-275730-650sjwyy	123	26	in	in	IN
cord-275730-650sjwyy	123	27	monocytic	monocytic	JJ
cord-275730-650sjwyy	123	28	cell	cell	NN
cord-275730-650sjwyy	123	29	lineages	lineage	NNS
cord-275730-650sjwyy	123	30	whereas	whereas	IN
cord-275730-650sjwyy	123	31	a	a	DT
cord-275730-650sjwyy	123	32	high	high	JJ
cord-275730-650sjwyy	123	33	-	-	HYPH
cord-275730-650sjwyy	123	34	dose	dose	NN
cord-275730-650sjwyy	123	35	resulted	result	VBD
cord-275730-650sjwyy	123	36	in	in	IN
cord-275730-650sjwyy	123	37	cellular	cellular	JJ
cord-275730-650sjwyy	123	38	activation	activation	NN
cord-275730-650sjwyy	123	39	at	at	IN
cord-275730-650sjwyy	123	40	distal	distal	JJ
cord-275730-650sjwyy	123	41	sites	site	NNS
cord-275730-650sjwyy	124	1	A	a	DT
cord-275730-650sjwyy	124	2	combination	combination	NN
cord-275730-650sjwyy	124	3	of	of	IN
cord-275730-650sjwyy	124	4	ADU	ADU	NNP
cord-275730-650sjwyy	124	5	-	-	HYPH
cord-275730-650sjwyy	124	6	S100	S100	NNP
cord-275730-650sjwyy	124	7	and	and	CC
cord-275730-650sjwyy	124	8	α	α	NNP
cord-275730-650sjwyy	124	9	-	-	HYPH
cord-275730-650sjwyy	124	10	CPI	CPI	NNP
cord-275730-650sjwyy	124	11	provide	provide	VB
cord-275730-650sjwyy	124	12	durable	durable	JJ
cord-275730-650sjwyy	124	13	immunity	immunity	NN
cord-275730-650sjwyy	124	14	even	even	RB
cord-275730-650sjwyy	124	15	against	against	IN
cord-275730-650sjwyy	124	16	cold	cold	JJ
cord-275730-650sjwyy	124	17	tumors	tumor	NNS
cord-275730-650sjwyy	124	18	Synthetic	synthetic	JJ
cord-275730-650sjwyy	124	19	RpRp	RpRp	NNP
cord-275730-650sjwyy	124	20	-	-	HYPH
cord-275730-650sjwyy	124	21	SS	SS	NNP
cord-275730-650sjwyy	124	22	-	-	HYPH
cord-275730-650sjwyy	124	23	CDG	CDG	NNP
cord-275730-650sjwyy	124	24	and	and	CC
cord-275730-650sjwyy	124	25	ML	ML	NNP
cord-275730-650sjwyy	124	26	-	-	HYPH
cord-275730-650sjwyy	124	27	RpRp	RpRp	NNP
cord-275730-650sjwyy	124	28	-	-	HYPH
cord-275730-650sjwyy	124	29	CDA	CDA	NNP
cord-275730-650sjwyy	124	30	in	in	IN
cord-275730-650sjwyy	124	31	PBAE	PBAE	NNS
cord-275730-650sjwyy	124	32	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	124	33	and	and	CC
cord-275730-650sjwyy	124	34	anti	anti	JJ
cord-275730-650sjwyy	124	35	-	-	JJ
cord-275730-650sjwyy	124	36	PD1	pd1	JJ
cord-275730-650sjwyy	124	37	antibody	antibody	NN
cord-275730-650sjwyy	124	38	(	(	-LRB-
cord-275730-650sjwyy	124	39	intratumoral	intratumoral	JJ
cord-275730-650sjwyy	124	40	)	)	-RRB-
cord-275730-650sjwyy	124	41	[	[	-LRB-
cord-275730-650sjwyy	124	42	56	56	CD
cord-275730-650sjwyy	124	43	]	]	-RRB-
cord-275730-650sjwyy	124	44	Enhanced	enhance	VBN
cord-275730-650sjwyy	124	45	shelf	shelf	NN
cord-275730-650sjwyy	124	46	-	-	HYPH
cord-275730-650sjwyy	124	47	life	life	NN
cord-275730-650sjwyy	124	48	stability	stability	NN
cord-275730-650sjwyy	124	49	for	for	IN
cord-275730-650sjwyy	124	50	up	up	IN
cord-275730-650sjwyy	124	51	to	to	TO
cord-275730-650sjwyy	124	52	nine	nine	CD
cord-275730-650sjwyy	124	53	months	month	NNS
cord-275730-650sjwyy	124	54	.	.	.
cord-275730-650sjwyy	125	1	A	a	DT
cord-275730-650sjwyy	125	2	10-fold	10-fold	JJ
cord-275730-650sjwyy	125	3	lower	low	JJR
cord-275730-650sjwyy	125	4	dose	dose	NN
cord-275730-650sjwyy	125	5	of	of	IN
cord-275730-650sjwyy	125	6	PBAE	PBAE	NNP
cord-275730-650sjwyy	125	7	/	/	SYM
cord-275730-650sjwyy	125	8	CDN	CDN	NNP
cord-275730-650sjwyy	125	9	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	125	10	with	with	IN
cord-275730-650sjwyy	125	11	α	α	NN
cord-275730-650sjwyy	125	12	-	-	HYPH
cord-275730-650sjwyy	125	13	PD1	pd1	NN
cord-275730-650sjwyy	125	14	antibody	antibody	NN
cord-275730-650sjwyy	125	15	resulted	result	VBD
cord-275730-650sjwyy	125	16	in	in	IN
cord-275730-650sjwyy	125	17	significantly	significantly	RB
cord-275730-650sjwyy	125	18	reduced	reduce	VBN
cord-275730-650sjwyy	125	19	tumor	tumor	NN
cord-275730-650sjwyy	125	20	growth	growth	NN
cord-275730-650sjwyy	125	21	and	and	CC
cord-275730-650sjwyy	125	22	reduction	reduction	NN
cord-275730-650sjwyy	125	23	as	as	IN
cord-275730-650sjwyy	125	24	compared	compare	VBN
cord-275730-650sjwyy	125	25	to	to	IN
cord-275730-650sjwyy	125	26	soluble	soluble	JJ
cord-275730-650sjwyy	125	27	CDN	CDN	NNP
cord-275730-650sjwyy	125	28	cGAMP	cgamp	NN
cord-275730-650sjwyy	125	29	in	in	IN
cord-275730-650sjwyy	125	30	acetalated	acetalated	JJ
cord-275730-650sjwyy	125	31	dextran	dextran	NN
cord-275730-650sjwyy	125	32	mps	mps	NNP
cord-275730-650sjwyy	125	33	(	(	-LRB-
cord-275730-650sjwyy	125	34	i.p	i.p	NNP
cord-275730-650sjwyy	125	35	.	.	NNP
cord-275730-650sjwyy	125	36	,	,	,
cord-275730-650sjwyy	125	37	i.m	i.m	NNP
cord-275730-650sjwyy	125	38	.	.	NNP
cord-275730-650sjwyy	125	39	,	,	,
cord-275730-650sjwyy	125	40	i.v	i.v	NNP
cord-275730-650sjwyy	125	41	.	.	NNP
cord-275730-650sjwyy	125	42	,	,	,
cord-275730-650sjwyy	125	43	and	and	CC
cord-275730-650sjwyy	125	44	intratumoral	intratumoral	NNP
cord-275730-650sjwyy	125	45	)	)	-RRB-
cord-275730-650sjwyy	126	1	[	[	-LRB-
cord-275730-650sjwyy	126	2	57	57	CD
cord-275730-650sjwyy	126	3	]	]	-RRB-
cord-275730-650sjwyy	126	4	Tumor	tumor	NN
cord-275730-650sjwyy	126	5	reduction	reduction	NN
cord-275730-650sjwyy	126	6	at	at	IN
cord-275730-650sjwyy	126	7	100	100	CD
cord-275730-650sjwyy	126	8	-	-	SYM
cord-275730-650sjwyy	126	9	1000	1000	CD
cord-275730-650sjwyy	126	10	fold	fold	VBP
cord-275730-650sjwyy	126	11	lower	lower	RBR
cord-275730-650sjwyy	126	12	dose	dose	NN
cord-275730-650sjwyy	126	13	as	as	IN
cord-275730-650sjwyy	126	14	compared	compare	VBN
cord-275730-650sjwyy	126	15	to	to	IN
cord-275730-650sjwyy	126	16	soluble	soluble	JJ
cord-275730-650sjwyy	126	17	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	127	1	The	the	DT
cord-275730-650sjwyy	127	2	synergistic	synergistic	JJ
cord-275730-650sjwyy	127	3	effect	effect	NN
cord-275730-650sjwyy	127	4	of	of	IN
cord-275730-650sjwyy	127	5	NK	NK	NNP
cord-275730-650sjwyy	127	6	cells	cell	NNS
cord-275730-650sjwyy	127	7	and	and	CC
cord-275730-650sjwyy	127	8	CD8	CD8	NNP
cord-275730-650sjwyy	127	9	+	+	CC
cord-275730-650sjwyy	127	10	T	T	NNP
cord-275730-650sjwyy	127	11	cells	cell	NNS
cord-275730-650sjwyy	127	12	resulted	result	VBD
cord-275730-650sjwyy	127	13	in	in	IN
cord-275730-650sjwyy	127	14	early	early	JJ
cord-275730-650sjwyy	127	15	anti	anti	JJ
cord-275730-650sjwyy	127	16	-	-	JJ
cord-275730-650sjwyy	127	17	tumor	tumor	JJ
cord-275730-650sjwyy	127	18	efficacy	efficacy	NN
cord-275730-650sjwyy	127	19	in	in	IN
cord-275730-650sjwyy	127	20	a	a	DT
cord-275730-650sjwyy	127	21	triple	triple	JJ
cord-275730-650sjwyy	127	22	-	-	HYPH
cord-275730-650sjwyy	127	23	negative	negative	JJ
cord-275730-650sjwyy	127	24	breast	breast	NN
cord-275730-650sjwyy	127	25	cancer	cancer	NN
cord-275730-650sjwyy	127	26	model	model	NN
cord-275730-650sjwyy	127	27	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	127	28	in	in	IN
cord-275730-650sjwyy	127	29	pH	ph	NN
cord-275730-650sjwyy	127	30	-	-	HYPH
cord-275730-650sjwyy	127	31	responsive	responsive	JJ
cord-275730-650sjwyy	127	32	polymersomes	polymersome	NNS
cord-275730-650sjwyy	127	33	(	(	-LRB-
cord-275730-650sjwyy	127	34	intratumoral	intratumoral	JJ
cord-275730-650sjwyy	127	35	)	)	-RRB-
cord-275730-650sjwyy	127	36	[	[	-LRB-
cord-275730-650sjwyy	127	37	63	63	CD
cord-275730-650sjwyy	127	38	]	]	-RRB-
cord-275730-650sjwyy	127	39	Recruitment	Recruitment	NNP
cord-275730-650sjwyy	127	40	of	of	IN
cord-275730-650sjwyy	127	41	active	active	JJ
cord-275730-650sjwyy	127	42	neutrophil	neutrophil	NN
cord-275730-650sjwyy	127	43	and	and	CC
cord-275730-650sjwyy	127	44	neutrophil	neutrophil	NN
cord-275730-650sjwyy	127	45	chemokine	chemokine	NN
cord-275730-650sjwyy	128	1	Cxcl1	Cxcl1	NNP
cord-275730-650sjwyy	129	1	in	in	IN
cord-275730-650sjwyy	129	2	TME	TME	NNP
cord-275730-650sjwyy	129	3	,	,	,
cord-275730-650sjwyy	129	4	the	the	DT
cord-275730-650sjwyy	129	5	polarization	polarization	NN
cord-275730-650sjwyy	129	6	of	of	IN
cord-275730-650sjwyy	129	7	M2	m2	JJ
cord-275730-650sjwyy	129	8	macrophage	macrophage	NN
cord-275730-650sjwyy	129	9	towards	towards	IN
cord-275730-650sjwyy	129	10	inflammatory	inflammatory	JJ
cord-275730-650sjwyy	129	11	profile	profile	NN
cord-275730-650sjwyy	129	12	;	;	,
cord-275730-650sjwyy	129	13	enhanced	enhance	VBN
cord-275730-650sjwyy	129	14	CDN	CDN	NNP
cord-275730-650sjwyy	129	15	accumulation	accumulation	NN
cord-275730-650sjwyy	129	16	in	in	IN
cord-275730-650sjwyy	129	17	lymph	lymph	NN
cord-275730-650sjwyy	129	18	nodes	node	NNS
cord-275730-650sjwyy	129	19	and	and	CC
cord-275730-650sjwyy	129	20	inhibited	inhibit	VBN
cord-275730-650sjwyy	129	21	contralateral	contralateral	JJ
cord-275730-650sjwyy	129	22	tumor	tumor	NN
cord-275730-650sjwyy	129	23	growth	growth	NN
cord-275730-650sjwyy	129	24	.	.	.
cord-275730-650sjwyy	130	1	Increased	increase	VBN
cord-275730-650sjwyy	130	2	CD8	CD8	NNP
cord-275730-650sjwyy	130	3	+	+	CC
cord-275730-650sjwyy	130	4	and	and	CC
cord-275730-650sjwyy	130	5	CD4	CD4	NNP
cord-275730-650sjwyy	130	6	+	+	CC
cord-275730-650sjwyy	130	7	T	t	NN
cord-275730-650sjwyy	130	8	cells	cell	NNS
cord-275730-650sjwyy	130	9	with	with	IN
cord-275730-650sjwyy	130	10	enhanced	enhanced	JJ
cord-275730-650sjwyy	130	11	CD8	CD8	NNP
cord-275730-650sjwyy	131	1	+	+	CC
cord-275730-650sjwyy	131	2	/CD4	/CD4	.
cord-275730-650sjwyy	132	1	+	+	CC
cord-275730-650sjwyy	132	2	T	t	NN
cord-275730-650sjwyy	132	3	cell	cell	NN
cord-275730-650sjwyy	132	4	ratio	ratio	NN
cord-275730-650sjwyy	132	5	in	in	IN
cord-275730-650sjwyy	132	6	TME	TME	NNP
cord-275730-650sjwyy	132	7	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	133	1	in	in	IN
cord-275730-650sjwyy	133	2	cationic	cationic	JJ
cord-275730-650sjwyy	133	3	liposomes	liposome	NNS
cord-275730-650sjwyy	133	4	(	(	-LRB-
cord-275730-650sjwyy	133	5	variable	variable	JJ
cord-275730-650sjwyy	133	6	PEG	peg	NN
cord-275730-650sjwyy	133	7	levels	level	NNS
cord-275730-650sjwyy	133	8	)	)	-RRB-
cord-275730-650sjwyy	133	9	(	(	-LRB-
cord-275730-650sjwyy	133	10	i.v	i.v	NNP
cord-275730-650sjwyy	133	11	.	.	.
cord-275730-650sjwyy	133	12	)	)	-RRB-
cord-275730-650sjwyy	134	1	[	[	-LRB-
cord-275730-650sjwyy	134	2	64	64	CD
cord-275730-650sjwyy	134	3	]	]	-RRB-
cord-275730-650sjwyy	134	4	Durable	durable	JJ
cord-275730-650sjwyy	134	5	anti	anti	JJ
cord-275730-650sjwyy	134	6	-	-	JJ
cord-275730-650sjwyy	134	7	tumor	tumor	JJ
cord-275730-650sjwyy	134	8	immunity	immunity	NN
cord-275730-650sjwyy	134	9	against	against	IN
cord-275730-650sjwyy	134	10	a	a	DT
cord-275730-650sjwyy	134	11	B16F10	b16f10	JJ
cord-275730-650sjwyy	134	12	orthotopic	orthotopic	JJ
cord-275730-650sjwyy	134	13	skin	skin	NN
cord-275730-650sjwyy	134	14	melanoma	melanoma	NN
cord-275730-650sjwyy	134	15	model	model	NN
cord-275730-650sjwyy	135	1	The	the	DT
cord-275730-650sjwyy	135	2	anti	anti	JJ
cord-275730-650sjwyy	135	3	-	-	JJ
cord-275730-650sjwyy	135	4	tumor	tumor	JJ
cord-275730-650sjwyy	135	5	activity	activity	NN
cord-275730-650sjwyy	135	6	of	of	IN
cord-275730-650sjwyy	135	7	cGAMP	cgamp	NN
cord-275730-650sjwyy	135	8	in	in	IN
cord-275730-650sjwyy	135	9	liposome	liposome	NN
cord-275730-650sjwyy	135	10	was	be	VBD
cord-275730-650sjwyy	135	11	obtained	obtain	VBN
cord-275730-650sjwyy	135	12	at	at	IN
cord-275730-650sjwyy	135	13	10	10	CD
cord-275730-650sjwyy	135	14	-	-	SYM
cord-275730-650sjwyy	135	15	100-fold	100-fold	CD
cord-275730-650sjwyy	135	16	lower	low	JJR
cord-275730-650sjwyy	135	17	concentration	concentration	NN
cord-275730-650sjwyy	135	18	than	than	IN
cord-275730-650sjwyy	135	19	soluble	soluble	JJ
cord-275730-650sjwyy	135	20	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	135	21	CDG	CDG	NNP
cord-275730-650sjwyy	135	22	in	in	IN
cord-275730-650sjwyy	135	23	cationic	cationic	JJ
cord-275730-650sjwyy	135	24	silica	silica	NN
cord-275730-650sjwyy	135	25	nps	nps	NNP
cord-275730-650sjwyy	135	26	(	(	-LRB-
cord-275730-650sjwyy	135	27	intratumoral	intratumoral	NNP
cord-275730-650sjwyy	135	28	)	)	-RRB-
cord-275730-650sjwyy	135	29	[	[	-LRB-
cord-275730-650sjwyy	135	30	65	65	CD
cord-275730-650sjwyy	135	31	]	]	-RRB-
cord-275730-650sjwyy	136	1	A	a	DT
cord-275730-650sjwyy	136	2	single	single	JJ
cord-275730-650sjwyy	136	3	intratumoral	intratumoral	JJ
cord-275730-650sjwyy	136	4	dose	dose	NN
cord-275730-650sjwyy	136	5	showed	show	VBD
cord-275730-650sjwyy	136	6	37.5	37.5	CD
cord-275730-650sjwyy	136	7	%	%	NN
cord-275730-650sjwyy	136	8	protection	protection	NN
cord-275730-650sjwyy	136	9	and	and	CC
cord-275730-650sjwyy	136	10	100	100	CD
cord-275730-650sjwyy	136	11	%	%	NN
cord-275730-650sjwyy	136	12	protection	protection	NN
cord-275730-650sjwyy	136	13	upon	upon	IN
cord-275730-650sjwyy	136	14	tumor	tumor	NN
cord-275730-650sjwyy	136	15	re	re	NN
cord-275730-650sjwyy	136	16	-	-	NN
cord-275730-650sjwyy	136	17	challenge	challenge	NN
cord-275730-650sjwyy	137	1	Intratumoral	intratumoral	JJ
cord-275730-650sjwyy	137	2	treatment	treatment	NN
cord-275730-650sjwyy	137	3	with	with	IN
cord-275730-650sjwyy	137	4	CDG	CDG	NNP
cord-275730-650sjwyy	137	5	/	/	SYM
cord-275730-650sjwyy	137	6	NP	NP	NNP
cord-275730-650sjwyy	137	7	in	in	IN
cord-275730-650sjwyy	137	8	OVA	OVA	NNP
cord-275730-650sjwyy	137	9	expressing	express	VBG
cord-275730-650sjwyy	137	10	B16-F10	b16-f10	PRP$
cord-275730-650sjwyy	137	11	melanoma	melanoma	NN
cord-275730-650sjwyy	137	12	cell	cell	NN
cord-275730-650sjwyy	137	13	line	line	NN
cord-275730-650sjwyy	137	14	induced	induce	VBN
cord-275730-650sjwyy	137	15	IFNγ	IFNγ	NNS
cord-275730-650sjwyy	137	16	and	and	CC
cord-275730-650sjwyy	137	17	TNFα	TNFα	NNS
cord-275730-650sjwyy	137	18	producing	produce	VBG
cord-275730-650sjwyy	137	19	OVA	ova	NN
cord-275730-650sjwyy	137	20	-	-	HYPH
cord-275730-650sjwyy	137	21	specific	specific	JJ
cord-275730-650sjwyy	137	22	CD8	CD8	NNP
cord-275730-650sjwyy	137	23	+	+	CC
cord-275730-650sjwyy	137	24	T	t	NN
cord-275730-650sjwyy	137	25	cells	cell	NNS
cord-275730-650sjwyy	137	26	in	in	IN
cord-275730-650sjwyy	137	27	PBMC	PBMC	NNP
cord-275730-650sjwyy	137	28	ADU	ADU	NNP
cord-275730-650sjwyy	137	29	-	-	HYPH
cord-275730-650sjwyy	137	30	S100	S100	NNP
cord-275730-650sjwyy	138	1	(	(	-LRB-
cord-275730-650sjwyy	138	2	Synthetic	Synthetic	NNP
cord-275730-650sjwyy	138	3	ML	ML	NNP
cord-275730-650sjwyy	138	4	-	-	HYPH
cord-275730-650sjwyy	138	5	RpRp	RpRp	NNP
cord-275730-650sjwyy	138	6	-	-	HYPH
cord-275730-650sjwyy	138	7	SS	SS	NNP
cord-275730-650sjwyy	138	8	-	-	HYPH
cord-275730-650sjwyy	138	9	CDA	CDA	NNP
cord-275730-650sjwyy	138	10	)	)	-RRB-
cord-275730-650sjwyy	138	11	in	in	IN
cord-275730-650sjwyy	138	12	saline	saline	NN
cord-275730-650sjwyy	138	13	(	(	-LRB-
cord-275730-650sjwyy	138	14	intratumoral	intratumoral	NNP
cord-275730-650sjwyy	138	15	)	)	-RRB-
cord-275730-650sjwyy	138	16	[	[	-LRB-
cord-275730-650sjwyy	138	17	29	29	CD
cord-275730-650sjwyy	138	18	,	,	,
cord-275730-650sjwyy	138	19	30	30	CD
cord-275730-650sjwyy	138	20	]	]	-RRB-
cord-275730-650sjwyy	139	1	NK	NK	NNP
cord-275730-650sjwyy	139	2	cell	cell	NN
cord-275730-650sjwyy	139	3	-	-	HYPH
cord-275730-650sjwyy	139	4	mediated	mediate	VBN
cord-275730-650sjwyy	139	5	and	and	CC
cord-275730-650sjwyy	139	6	CD8	CD8	NNP
cord-275730-650sjwyy	139	7	+	+	CC
cord-275730-650sjwyy	139	8	T	T	NNP
cord-275730-650sjwyy	139	9	cell	cell	NN
cord-275730-650sjwyy	139	10	dispensable	dispensable	JJ
cord-275730-650sjwyy	139	11	tumor	tumor	NN
cord-275730-650sjwyy	139	12	regression	regression	NN
cord-275730-650sjwyy	139	13	and	and	CC
cord-275730-650sjwyy	139	14	clearance	clearance	NN
cord-275730-650sjwyy	139	15	in	in	IN
cord-275730-650sjwyy	139	16	local	local	JJ
cord-275730-650sjwyy	139	17	and	and	CC
cord-275730-650sjwyy	139	18	distal	distal	JJ
cord-275730-650sjwyy	139	19	tumor	tumor	NN
cord-275730-650sjwyy	139	20	sites	site	NNS
cord-275730-650sjwyy	139	21	.	.	.
cord-275730-650sjwyy	140	1	Increased	increase	VBN
cord-275730-650sjwyy	140	2	cytokines	cytokine	NNS
cord-275730-650sjwyy	140	3	and	and	CC
cord-275730-650sjwyy	140	4	chemokines	chemokine	NNS
cord-275730-650sjwyy	140	5	and	and	CC
cord-275730-650sjwyy	140	6	innate	innate	JJ
cord-275730-650sjwyy	140	7	immune	immune	JJ
cord-275730-650sjwyy	140	8	cells	cell	NNS
cord-275730-650sjwyy	140	9	(	(	-LRB-
cord-275730-650sjwyy	140	10	macrophages	macrophage	NNS
cord-275730-650sjwyy	140	11	,	,	,
cord-275730-650sjwyy	140	12	neutrophils	neutrophil	NNS
cord-275730-650sjwyy	140	13	)	)	-RRB-
cord-275730-650sjwyy	140	14	in	in	IN
cord-275730-650sjwyy	140	15	the	the	DT
cord-275730-650sjwyy	140	16	TME	TME	NNP
cord-275730-650sjwyy	140	17	and	and	CC
cord-275730-650sjwyy	140	18	tumor	tumor	NN
cord-275730-650sjwyy	140	19	dLNs	dlns	XX
cord-275730-650sjwyy	141	1	leading	lead	VBG
cord-275730-650sjwyy	141	2	to	to	TO
cord-275730-650sjwyy	141	3	complete	complete	JJ
cord-275730-650sjwyy	141	4	tumor	tumor	NN
cord-275730-650sjwyy	141	5	clearance	clearance	NN
cord-275730-650sjwyy	141	6	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	142	1	in	in	IN
cord-275730-650sjwyy	142	2	phosphatidylserine	phosphatidylserine	NN
cord-275730-650sjwyy	142	3	liposome	liposome	NN
cord-275730-650sjwyy	142	4	/	/	SYM
cord-275730-650sjwyy	142	5	radiotherapy	radiotherapy	NN
cord-275730-650sjwyy	142	6	(	(	-LRB-
cord-275730-650sjwyy	142	7	inhalation	inhalation	NN
cord-275730-650sjwyy	142	8	)	)	-RRB-
cord-275730-650sjwyy	142	9	[	[	-LRB-
cord-275730-650sjwyy	142	10	66	66	CD
cord-275730-650sjwyy	142	11	]	]	-RRB-
cord-275730-650sjwyy	142	12	Enhanced	enhanced	JJ
cord-275730-650sjwyy	142	13	cytosolic	cytosolic	JJ
cord-275730-650sjwyy	142	14	release	release	NN
cord-275730-650sjwyy	142	15	of	of	IN
cord-275730-650sjwyy	142	16	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	142	17	,	,	,
cord-275730-650sjwyy	142	18	efficient	efficient	JJ
cord-275730-650sjwyy	142	19	STING	sting	NN
cord-275730-650sjwyy	142	20	signaling	signal	VBG
cord-275730-650sjwyy	142	21	,	,	,
cord-275730-650sjwyy	142	22	and	and	CC
cord-275730-650sjwyy	142	23	type	type	NN
cord-275730-650sjwyy	142	24	I	-PRON-	PRP
cord-275730-650sjwyy	142	25	IFN	IFN	NNP
cord-275730-650sjwyy	142	26	production	production	NN
cord-275730-650sjwyy	142	27	in	in	IN
cord-275730-650sjwyy	142	28	APCs	apc	NNS
cord-275730-650sjwyy	142	29	resulting	result	VBG
cord-275730-650sjwyy	142	30	in	in	IN
cord-275730-650sjwyy	142	31	a	a	DT
cord-275730-650sjwyy	142	32	pro	pro	JJ
cord-275730-650sjwyy	142	33	-	-	JJ
cord-275730-650sjwyy	142	34	inflammatory	inflammatory	JJ
cord-275730-650sjwyy	142	35	TME	TME	NNP
cord-275730-650sjwyy	142	36	and	and	CC
cord-275730-650sjwyy	142	37	suppressed	suppress	VBN
cord-275730-650sjwyy	142	38	Tregs	Tregs	NNP
cord-275730-650sjwyy	142	39	production	production	NN
cord-275730-650sjwyy	142	40	in	in	IN
cord-275730-650sjwyy	142	41	TME	TME	NNP
cord-275730-650sjwyy	142	42	.	.	.
cord-275730-650sjwyy	143	1	Liposome	liposome	NN
cord-275730-650sjwyy	143	2	/	/	SYM
cord-275730-650sjwyy	143	3	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	143	4	and	and	CC
cord-275730-650sjwyy	143	5	radiation	radiation	NN
cord-275730-650sjwyy	143	6	therapy	therapy	NN
cord-275730-650sjwyy	143	7	-	-	HYPH
cord-275730-650sjwyy	143	8	induced	induce	VBN
cord-275730-650sjwyy	143	9	complete	complete	JJ
cord-275730-650sjwyy	143	10	regression	regression	NN
cord-275730-650sjwyy	143	11	of	of	IN
cord-275730-650sjwyy	143	12	lung	lung	NN
cord-275730-650sjwyy	143	13	metastasis	metastasis	NN
cord-275730-650sjwyy	143	14	and	and	CC
cord-275730-650sjwyy	143	15	inhibited	inhibited	JJ
cord-275730-650sjwyy	143	16	metastasis	metastasis	NN
cord-275730-650sjwyy	143	17	in	in	IN
cord-275730-650sjwyy	143	18	both	both	CC
cord-275730-650sjwyy	143	19	the	the	DT
cord-275730-650sjwyy	143	20	irradiated	irradiated	JJ
cord-275730-650sjwyy	143	21	and	and	CC
cord-275730-650sjwyy	143	22	non	non	JJ
cord-275730-650sjwyy	143	23	-	-	JJ
cord-275730-650sjwyy	143	24	irradiated	irradiated	JJ
cord-275730-650sjwyy	143	25	lung	lung	NN
cord-275730-650sjwyy	143	26	STINGVAX	STINGVAX	NNP
cord-275730-650sjwyy	143	27	Soluble	soluble	JJ
cord-275730-650sjwyy	143	28	CDA	CDA	NNP
cord-275730-650sjwyy	143	29	/	/	SYM
cord-275730-650sjwyy	143	30	Synthetic	synthetic	JJ
cord-275730-650sjwyy	143	31	RR	rr	NN
cord-275730-650sjwyy	143	32	-	-	HYPH
cord-275730-650sjwyy	143	33	S2-CDA	S2-CDA	NNP
cord-275730-650sjwyy	143	34	/	/	SYM
cord-275730-650sjwyy	143	35	Synthetic	Synthetic	NNP
cord-275730-650sjwyy	143	36	ML	ML	NNP
cord-275730-650sjwyy	143	37	-	-	HYPH
cord-275730-650sjwyy	143	38	RR	rr	NN
cord-275730-650sjwyy	143	39	-	-	HYPH
cord-275730-650sjwyy	143	40	S2-CDA	S2-CDA	NNP
cord-275730-650sjwyy	143	41	(	(	-LRB-
cord-275730-650sjwyy	143	42	s.c	s.c	NNP
cord-275730-650sjwyy	143	43	.	.	NNP
cord-275730-650sjwyy	143	44	)	)	-RRB-
cord-275730-650sjwyy	144	1	[	[	-LRB-
cord-275730-650sjwyy	144	2	17	17	CD
cord-275730-650sjwyy	144	3	]	]	-RRB-
cord-275730-650sjwyy	145	1	Enhanced	enhanced	JJ
cord-275730-650sjwyy	145	2	IFN	IFN	NNP
cord-275730-650sjwyy	145	3	-	-	HYPH
cord-275730-650sjwyy	145	4	γ	γ	NNP
cord-275730-650sjwyy	145	5	+	+	CC
cord-275730-650sjwyy	146	1	tumor	tumor	NN
cord-275730-650sjwyy	146	2	-	-	HYPH
cord-275730-650sjwyy	146	3	infiltrating	infiltrate	VBG
cord-275730-650sjwyy	146	4	CD8	CD8	NNP
cord-275730-650sjwyy	146	5	+	+	CC
cord-275730-650sjwyy	146	6	T	T	NNP
cord-275730-650sjwyy	146	7	cells	cell	NNS
cord-275730-650sjwyy	146	8	.	.	.
cord-275730-650sjwyy	147	1	STINGVAX	STINGVAX	NNP
cord-275730-650sjwyy	147	2	in	in	IN
cord-275730-650sjwyy	147	3	combination	combination	NN
cord-275730-650sjwyy	147	4	with	with	IN
cord-275730-650sjwyy	147	5	synthetic	synthetic	JJ
cord-275730-650sjwyy	147	6	CDA	cda	NN
cord-275730-650sjwyy	147	7	-	-	HYPH
cord-275730-650sjwyy	147	8	induced	induce	VBN
cord-275730-650sjwyy	147	9	type	type	NN
cord-275730-650sjwyy	147	10	I	-PRON-	PRP
cord-275730-650sjwyy	147	11	IFN	IFN	NNP
cord-275730-650sjwyy	147	12	,	,	,
cord-275730-650sjwyy	147	13	MHC	MHC	NNP
cord-275730-650sjwyy	147	14	I	I	NNP
cord-275730-650sjwyy	147	15	,	,	,
cord-275730-650sjwyy	147	16	CD80	CD80	NNP
cord-275730-650sjwyy	147	17	,	,	,
cord-275730-650sjwyy	147	18	CD83	CD83	NNP
cord-275730-650sjwyy	147	19	,	,	,
cord-275730-650sjwyy	148	1	CD86	CD86	NNP
cord-275730-650sjwyy	148	2	in	in	IN
cord-275730-650sjwyy	148	3	monocytes	monocyte	NNS
cord-275730-650sjwyy	148	4	and	and	CC
cord-275730-650sjwyy	148	5	DC	DC	NNP
cord-275730-650sjwyy	148	6	obtained	obtain	VBD
cord-275730-650sjwyy	148	7	from	from	IN
cord-275730-650sjwyy	148	8	donor	donor	NN
cord-275730-650sjwyy	148	9	PBMCs	pbmc	NNS
cord-275730-650sjwyy	148	10	Synthetic	synthetic	JJ
cord-275730-650sjwyy	148	11	DMXAA	DMXAA	NNP
cord-275730-650sjwyy	148	12	(	(	-LRB-
cord-275730-650sjwyy	148	13	i.p	i.p	NNP
cord-275730-650sjwyy	148	14	.	.	NNP
cord-275730-650sjwyy	148	15	,	,	,
cord-275730-650sjwyy	148	16	i.v	i.v	NNP
cord-275730-650sjwyy	148	17	.	.	NNP
cord-275730-650sjwyy	148	18	,	,	,
cord-275730-650sjwyy	148	19	intratumoral	intratumoral	NNP
cord-275730-650sjwyy	148	20	)	)	-RRB-
cord-275730-650sjwyy	148	21	[	[	-LRB-
cord-275730-650sjwyy	148	22	16	16	CD
cord-275730-650sjwyy	148	23	,	,	,
cord-275730-650sjwyy	148	24	67	67	CD
cord-275730-650sjwyy	148	25	,	,	,
cord-275730-650sjwyy	148	26	68	68	CD
cord-275730-650sjwyy	148	27	]	]	-RRB-
cord-275730-650sjwyy	148	28	Tumor	tumor	NN
cord-275730-650sjwyy	148	29	-	-	HYPH
cord-275730-650sjwyy	148	30	specific	specific	JJ
cord-275730-650sjwyy	148	31	CD8	CD8	NNP
cord-275730-650sjwyy	148	32	+	+	CC
cord-275730-650sjwyy	148	33	T	T	NNP
cord-275730-650sjwyy	148	34	cell	cell	NN
cord-275730-650sjwyy	148	35	,	,	,
cord-275730-650sjwyy	148	36	and	and	CC
cord-275730-650sjwyy	148	37	long	long	JJ
cord-275730-650sjwyy	148	38	term	term	NN
cord-275730-650sjwyy	148	39	protection	protection	NN
cord-275730-650sjwyy	148	40	in	in	IN
cord-275730-650sjwyy	148	41	a	a	DT
cord-275730-650sjwyy	148	42	C1498.SIY	c1498.siy	JJ
cord-275730-650sjwyy	148	43	acute	acute	JJ
cord-275730-650sjwyy	148	44	leukemia	leukemia	NN
cord-275730-650sjwyy	148	45	model	model	NN
cord-275730-650sjwyy	148	46	Anti	anti	JJ
cord-275730-650sjwyy	148	47	-	-	JJ
cord-275730-650sjwyy	148	48	tumor	tumor	JJ
cord-275730-650sjwyy	148	49	immunity	immunity	NN
cord-275730-650sjwyy	148	50	in	in	IN
cord-275730-650sjwyy	148	51	distal	distal	JJ
cord-275730-650sjwyy	148	52	tumor	tumor	NN
cord-275730-650sjwyy	148	53	sites	site	NNS
cord-275730-650sjwyy	148	54	Macrophage	macrophage	NN
cord-275730-650sjwyy	148	55	repolarization	repolarization	NN
cord-275730-650sjwyy	148	56	in	in	IN
cord-275730-650sjwyy	148	57	non	non	JJ
cord-275730-650sjwyy	148	58	-	-	JJ
cord-275730-650sjwyy	148	59	small	small	JJ
cord-275730-650sjwyy	148	60	cell	cell	NN
cord-275730-650sjwyy	148	61	lung	lung	NN
cord-275730-650sjwyy	148	62	cancer	cancer	NN
cord-275730-650sjwyy	148	63	model	model	NN
cord-275730-650sjwyy	148	64	compared	compare	VBN
cord-275730-650sjwyy	148	65	to	to	IN
cord-275730-650sjwyy	148	66	the	the	DT
cord-275730-650sjwyy	148	67	soluble	soluble	JJ
cord-275730-650sjwyy	148	68	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	149	1	[	[	-LRB-
cord-275730-650sjwyy	149	2	55	55	CD
cord-275730-650sjwyy	149	3	]	]	-RRB-
cord-275730-650sjwyy	149	4	.	.	.
cord-275730-650sjwyy	150	1	However	however	RB
cord-275730-650sjwyy	150	2	,	,	,
cord-275730-650sjwyy	150	3	the	the	DT
cord-275730-650sjwyy	150	4	antigen	antigen	NN
cord-275730-650sjwyy	150	5	-	-	HYPH
cord-275730-650sjwyy	150	6	specific	specific	JJ
cord-275730-650sjwyy	150	7	antibody	antibody	NN
cord-275730-650sjwyy	150	8	levels	level	NNS
cord-275730-650sjwyy	150	9	of	of	IN
cord-275730-650sjwyy	150	10	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	150	11	immunized	immunize	VBN
cord-275730-650sjwyy	150	12	vs.	vs.	IN
cord-275730-650sjwyy	150	13	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	150	14	/	/	SYM
cord-275730-650sjwyy	150	15	LH	LH	NNP
cord-275730-650sjwyy	150	16	hydrogel	hydrogel	NN
cord-275730-650sjwyy	150	17	immunized	immunize	VBD
cord-275730-650sjwyy	150	18	mice	mouse	NNS
cord-275730-650sjwyy	150	19	were	be	VBD
cord-275730-650sjwyy	150	20	comparable	comparable	JJ
cord-275730-650sjwyy	150	21	[	[	-LRB-
cord-275730-650sjwyy	150	22	55	55	CD
cord-275730-650sjwyy	150	23	]	]	-RRB-
cord-275730-650sjwyy	150	24	.	.	.
cord-275730-650sjwyy	151	1	Moreover	moreover	RB
cord-275730-650sjwyy	151	2	,	,	,
cord-275730-650sjwyy	151	3	in	in	IN
cord-275730-650sjwyy	151	4	2015	2015	CD
cord-275730-650sjwyy	151	5	,	,	,
cord-275730-650sjwyy	151	6	Hanson	Hanson	NNP
cord-275730-650sjwyy	151	7	M.C.	M.C.	NNP
cord-275730-650sjwyy	151	8	et	et	NNP
cord-275730-650sjwyy	151	9	al	al	NNP
cord-275730-650sjwyy	151	10	.	.	NNP
cord-275730-650sjwyy	151	11	showed	show	VBD
cord-275730-650sjwyy	151	12	that	that	IN
cord-275730-650sjwyy	151	13	CDG	CDG	NNP
cord-275730-650sjwyy	151	14	encapsulated	encapsulate	VBD
cord-275730-650sjwyy	151	15	in	in	IN
cord-275730-650sjwyy	151	16	a	a	DT
cord-275730-650sjwyy	151	17	PEGylated	pegylated	JJ
cord-275730-650sjwyy	151	18	liposome	liposome	NN
cord-275730-650sjwyy	151	19	enhanced	enhance	VBD
cord-275730-650sjwyy	151	20	its	-PRON-	PRP$
cord-275730-650sjwyy	151	21	retention	retention	NN
cord-275730-650sjwyy	151	22	in	in	IN
cord-275730-650sjwyy	151	23	the	the	DT
cord-275730-650sjwyy	151	24	lymph	lymph	NN
cord-275730-650sjwyy	151	25	node	node	NN
cord-275730-650sjwyy	151	26	by	by	IN
cord-275730-650sjwyy	151	27	15-fold	15-fold	CD
cord-275730-650sjwyy	151	28	,	,	,
cord-275730-650sjwyy	151	29	which	which	WDT
cord-275730-650sjwyy	151	30	otherwise	otherwise	RB
cord-275730-650sjwyy	151	31	disseminated	disseminate	VBD
cord-275730-650sjwyy	151	32	into	into	IN
cord-275730-650sjwyy	151	33	the	the	DT
cord-275730-650sjwyy	151	34	blood	blood	NN
cord-275730-650sjwyy	151	35	following	follow	VBG
cord-275730-650sjwyy	151	36	s.c	s.c	NNP
cord-275730-650sjwyy	151	37	.	.	NNP
cord-275730-650sjwyy	151	38	immunization	immunization	NN
cord-275730-650sjwyy	151	39	[	[	-LRB-
cord-275730-650sjwyy	151	40	58	58	CD
cord-275730-650sjwyy	151	41	]	]	-RRB-
cord-275730-650sjwyy	151	42	.	.	.
cord-275730-650sjwyy	152	1	Incorporation	Incorporation	NNP
cord-275730-650sjwyy	152	2	of	of	IN
cord-275730-650sjwyy	152	3	HIV	HIV	NNP
cord-275730-650sjwyy	152	4	GP41	GP41	NNP
cord-275730-650sjwyy	152	5	antigen	antigen	NN
cord-275730-650sjwyy	152	6	membrane	membrane	NN
cord-275730-650sjwyy	152	7	-	-	HYPH
cord-275730-650sjwyy	152	8	proximal	proximal	JJ
cord-275730-650sjwyy	152	9	external	external	JJ
cord-275730-650sjwyy	152	10	protein	protein	NN
cord-275730-650sjwyy	152	11	(	(	-LRB-
cord-275730-650sjwyy	152	12	MPER	MPER	NNP
cord-275730-650sjwyy	152	13	)	)	-RRB-
cord-275730-650sjwyy	152	14	with	with	IN
cord-275730-650sjwyy	152	15	a	a	DT
cord-275730-650sjwyy	152	16	CDG	CDG	NNP
cord-275730-650sjwyy	152	17	encapsulated	encapsulate	VBN
cord-275730-650sjwyy	152	18	liposome	liposome	NN
cord-275730-650sjwyy	152	19	enhanced	enhance	VBD
cord-275730-650sjwyy	152	20	5.3-fold	5.3-fold	CD
cord-275730-650sjwyy	152	21	antigen	antigen	NN
cord-275730-650sjwyy	152	22	-	-	HYPH
cord-275730-650sjwyy	152	23	specific	specific	JJ
cord-275730-650sjwyy	152	24	Tfh	Tfh	NNP
cord-275730-650sjwyy	152	25	cell	cell	NN
cord-275730-650sjwyy	152	26	formation	formation	NN
cord-275730-650sjwyy	152	27	as	as	IN
cord-275730-650sjwyy	152	28	compared	compare	VBN
cord-275730-650sjwyy	152	29	to	to	IN
cord-275730-650sjwyy	152	30	CDG	CDG	NNP
cord-275730-650sjwyy	152	31	or	or	CC
cord-275730-650sjwyy	152	32	liposome	liposome	NN
cord-275730-650sjwyy	152	33	only	only	RB
cord-275730-650sjwyy	152	34	immunized	immunize	VBD
cord-275730-650sjwyy	152	35	mice	mouse	NNS
cord-275730-650sjwyy	152	36	[	[	-LRB-
cord-275730-650sjwyy	152	37	58	58	CD
cord-275730-650sjwyy	152	38	]	]	-RRB-
cord-275730-650sjwyy	152	39	.	.	.
cord-275730-650sjwyy	153	1	There	there	EX
cord-275730-650sjwyy	153	2	were	be	VBD
cord-275730-650sjwyy	153	3	improved	improve	VBN
cord-275730-650sjwyy	153	4	germinal	germinal	JJ
cord-275730-650sjwyy	153	5	center	center	NN
cord-275730-650sjwyy	153	6	B	B	NNP
cord-275730-650sjwyy	153	7	cell	cell	NN
cord-275730-650sjwyy	153	8	production	production	NN
cord-275730-650sjwyy	153	9	and	and	CC
cord-275730-650sjwyy	153	10	11-fold	11-fold	CD
cord-275730-650sjwyy	153	11	increased	increase	VBN
cord-275730-650sjwyy	153	12	antigen	antigen	NN
cord-275730-650sjwyy	153	13	-	-	HYPH
cord-275730-650sjwyy	153	14	specific	specific	JJ
cord-275730-650sjwyy	153	15	IgG	igg	NN
cord-275730-650sjwyy	153	16	titers	titer	NNS
cord-275730-650sjwyy	153	17	[	[	-LRB-
cord-275730-650sjwyy	153	18	58	58	CD
cord-275730-650sjwyy	153	19	]	]	-RRB-
cord-275730-650sjwyy	153	20	.	.	.
cord-275730-650sjwyy	154	1	Lastly	lastly	RB
cord-275730-650sjwyy	154	2	,	,	,
cord-275730-650sjwyy	154	3	the	the	DT
cord-275730-650sjwyy	154	4	humoral	humoral	JJ
cord-275730-650sjwyy	154	5	responses	response	NNS
cord-275730-650sjwyy	154	6	were	be	VBD
cord-275730-650sjwyy	154	7	more	more	RBR
cord-275730-650sjwyy	154	8	durable	durable	JJ
cord-275730-650sjwyy	154	9	than	than	IN
cord-275730-650sjwyy	154	10	vaccines	vaccine	NNS
cord-275730-650sjwyy	154	11	administered	administer	VBN
cord-275730-650sjwyy	154	12	with	with	IN
cord-275730-650sjwyy	154	13	the	the	DT
cord-275730-650sjwyy	154	14	TLR	TLR	NNP
cord-275730-650sjwyy	154	15	agonist	agonist	NN
cord-275730-650sjwyy	154	16	MPLA	MPLA	NNP
cord-275730-650sjwyy	154	17	[	[	-LRB-
cord-275730-650sjwyy	154	18	58	58	CD
cord-275730-650sjwyy	154	19	]	]	-RRB-
cord-275730-650sjwyy	154	20	.	.	.
cord-275730-650sjwyy	155	1	Microparticles	microparticle	NNS
cord-275730-650sjwyy	155	2	have	have	VBP
cord-275730-650sjwyy	155	3	the	the	DT
cord-275730-650sjwyy	155	4	advantage	advantage	NN
cord-275730-650sjwyy	155	5	of	of	IN
cord-275730-650sjwyy	155	6	biocompatibility	biocompatibility	NN
cord-275730-650sjwyy	155	7	,	,	,
cord-275730-650sjwyy	155	8	tunable	tunable	JJ
cord-275730-650sjwyy	155	9	biodegradability	biodegradability	NN
cord-275730-650sjwyy	155	10	,	,	,
cord-275730-650sjwyy	155	11	ease	ease	NN
cord-275730-650sjwyy	155	12	of	of	IN
cord-275730-650sjwyy	155	13	synthesis	synthesis	NN
cord-275730-650sjwyy	155	14	,	,	,
cord-275730-650sjwyy	155	15	and	and	CC
cord-275730-650sjwyy	155	16	stability	stability	NN
cord-275730-650sjwyy	155	17	at	at	IN
cord-275730-650sjwyy	155	18	elevated	elevated	JJ
cord-275730-650sjwyy	155	19	temperatures	temperature	NNS
cord-275730-650sjwyy	155	20	.	.	.
cord-275730-650sjwyy	156	1	Acetylated	acetylated	NN
cord-275730-650sjwyy	156	2	-	-	HYPH
cord-275730-650sjwyy	156	3	dextran	dextran	NN
cord-275730-650sjwyy	156	4	encapsulating	encapsulate	VBG
cord-275730-650sjwyy	156	5	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	156	6	microparticles	microparticle	NNS
cord-275730-650sjwyy	156	7	enhanced	enhance	VBN
cord-275730-650sjwyy	156	8	type	type	NN
cord-275730-650sjwyy	156	9	I	-PRON-	PRP
cord-275730-650sjwyy	156	10	IFNs	ifns	VBP
cord-275730-650sjwyy	156	11	responses	response	NNS
cord-275730-650sjwyy	156	12	by	by	IN
cord-275730-650sjwyy	156	13	nearly	nearly	RB
cord-275730-650sjwyy	156	14	1000-fold	1000-fold	CD
cord-275730-650sjwyy	156	15	in	in	IN
cord-275730-650sjwyy	156	16	vitro	vitro	FW
cord-275730-650sjwyy	156	17	and	and	CC
cord-275730-650sjwyy	156	18	50-fold	50-fold	JJ
cord-275730-650sjwyy	156	19	in	in	IN
cord-275730-650sjwyy	156	20	vivo	vivo	NN
cord-275730-650sjwyy	156	21	[	[	-LRB-
cord-275730-650sjwyy	156	22	69	69	CD
cord-275730-650sjwyy	156	23	]	]	-RRB-
cord-275730-650sjwyy	156	24	.	.	.
cord-275730-650sjwyy	157	1	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	157	2	microparticles	microparticles	NNPS
cord-275730-650sjwyy	157	3	(	(	-LRB-
cord-275730-650sjwyy	157	4	i.m	i.m	NNP
cord-275730-650sjwyy	157	5	.	.	NNP
cord-275730-650sjwyy	157	6	)	)	-RRB-
cord-275730-650sjwyy	157	7	increased	increase	VBD
cord-275730-650sjwyy	157	8	antigen	antigen	NN
cord-275730-650sjwyy	157	9	-	-	HYPH
cord-275730-650sjwyy	157	10	specific	specific	JJ
cord-275730-650sjwyy	157	11	antibody	antibody	NN
cord-275730-650sjwyy	157	12	titers	titer	NNS
cord-275730-650sjwyy	157	13	by~100-fold	by~100-fold	NNP
cord-275730-650sjwyy	157	14	,	,	,
cord-275730-650sjwyy	157	15	enhanced	enhanced	JJ
cord-275730-650sjwyy	157	16	Th1	th1	NN
cord-275730-650sjwyy	157	17	responses	response	NNS
cord-275730-650sjwyy	157	18	,	,	,
cord-275730-650sjwyy	157	19	and	and	CC
cord-275730-650sjwyy	157	20	expanded	expand	VBD
cord-275730-650sjwyy	157	21	germinal	germinal	JJ
cord-275730-650sjwyy	157	22	center	center	NN
cord-275730-650sjwyy	157	23	B	B	NNP
cord-275730-650sjwyy	157	24	cells	cell	NNS
cord-275730-650sjwyy	157	25	[	[	-LRB-
cord-275730-650sjwyy	157	26	69	69	CD
cord-275730-650sjwyy	157	27	]	]	-RRB-
cord-275730-650sjwyy	157	28	.	.	.
cord-275730-650sjwyy	158	1	The	the	DT
cord-275730-650sjwyy	158	2	encapsulated	encapsulate	VBN
cord-275730-650sjwyy	158	3	cGAMP	cgamp	NN
cord-275730-650sjwyy	158	4	with	with	IN
cord-275730-650sjwyy	158	5	hemagglutinin	hemagglutinin	NN
cord-275730-650sjwyy	158	6	antigen	antigen	NN
cord-275730-650sjwyy	158	7	achieved	achieve	VBD
cord-275730-650sjwyy	158	8	nearly	nearly	RB
cord-275730-650sjwyy	158	9	complete	complete	JJ
cord-275730-650sjwyy	158	10	protective	protective	JJ
cord-275730-650sjwyy	158	11	immunity	immunity	NN
cord-275730-650sjwyy	158	12	against	against	IN
cord-275730-650sjwyy	158	13	a	a	DT
cord-275730-650sjwyy	158	14	lethal	lethal	JJ
cord-275730-650sjwyy	158	15	challenge	challenge	NN
cord-275730-650sjwyy	158	16	of	of	IN
cord-275730-650sjwyy	158	17	influenza	influenza	NN
cord-275730-650sjwyy	158	18	strain	strain	VB
cord-275730-650sjwyy	158	19	A	a	DT
cord-275730-650sjwyy	158	20	/	/	SYM
cord-275730-650sjwyy	158	21	Puerto	Puerto	NNP
cord-275730-650sjwyy	158	22	Rico/8/1934	Rico/8/1934	NNP
cord-275730-650sjwyy	158	23	H1N1	H1N1	NNP
cord-275730-650sjwyy	158	24	(	(	-LRB-
cord-275730-650sjwyy	158	25	PR8	PR8	NNP
cord-275730-650sjwyy	158	26	)	)	-RRB-
cord-275730-650sjwyy	158	27	seven	seven	CD
cord-275730-650sjwyy	158	28	months	month	NNS
cord-275730-650sjwyy	158	29	post	post	NN
cord-275730-650sjwyy	158	30	-	-	NN
cord-275730-650sjwyy	158	31	immunization	immunization	JJ
cord-275730-650sjwyy	158	32	[	[	-LRB-
cord-275730-650sjwyy	158	33	69	69	CD
cord-275730-650sjwyy	158	34	]	]	-RRB-
cord-275730-650sjwyy	158	35	.	.	.
cord-275730-650sjwyy	159	1	The	the	DT
cord-275730-650sjwyy	159	2	dose	dose	NN
cord-275730-650sjwyy	159	3	of	of	IN
cord-275730-650sjwyy	159	4	CDN	CDN	NNP
cord-275730-650sjwyy	159	5	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	159	6	(	(	-LRB-
cord-275730-650sjwyy	159	7	200	200	CD
cord-275730-650sjwyy	159	8	ng	ng	NN
cord-275730-650sjwyy	159	9	)	)	-RRB-
cord-275730-650sjwyy	159	10	used	use	VBN
cord-275730-650sjwyy	159	11	was	be	VBD
cord-275730-650sjwyy	159	12	100-fold	100-fold	CD
cord-275730-650sjwyy	159	13	lower	low	JJR
cord-275730-650sjwyy	159	14	than	than	IN
cord-275730-650sjwyy	159	15	previous	previous	JJ
cord-275730-650sjwyy	159	16	reports	report	NNS
cord-275730-650sjwyy	159	17	[	[	-LRB-
cord-275730-650sjwyy	159	18	69	69	CD
cord-275730-650sjwyy	159	19	]	]	-RRB-
cord-275730-650sjwyy	159	20	.	.	.
cord-275730-650sjwyy	160	1	Lastly	lastly	RB
cord-275730-650sjwyy	160	2	,	,	,
cord-275730-650sjwyy	160	3	the	the	DT
cord-275730-650sjwyy	160	4	encapsulated	encapsulate	VBN
cord-275730-650sjwyy	160	5	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	160	6	elicited	elicit	VBD
cord-275730-650sjwyy	160	7	no	no	DT
cord-275730-650sjwyy	160	8	observable	observable	JJ
cord-275730-650sjwyy	160	9	toxicity	toxicity	NN
cord-275730-650sjwyy	160	10	in	in	IN
cord-275730-650sjwyy	160	11	animals	animal	NNS
cord-275730-650sjwyy	160	12	[	[	-LRB-
cord-275730-650sjwyy	160	13	69	69	CD
cord-275730-650sjwyy	160	14	]	]	-RRB-
cord-275730-650sjwyy	160	15	.	.	.
cord-275730-650sjwyy	161	1	Most	most	RBS
cord-275730-650sjwyy	161	2	recently	recently	RB
cord-275730-650sjwyy	161	3	,	,	,
cord-275730-650sjwyy	161	4	Wang	Wang	NNP
cord-275730-650sjwyy	161	5	J.	J.	NNP
cord-275730-650sjwyy	161	6	et	et	NNP
cord-275730-650sjwyy	161	7	al	al	NNP
cord-275730-650sjwyy	161	8	.	.	NNP
cord-275730-650sjwyy	161	9	designed	design	VBD
cord-275730-650sjwyy	161	10	a	a	DT
cord-275730-650sjwyy	161	11	biomimetic	biomimetic	JJ
cord-275730-650sjwyy	161	12	pulmonary	pulmonary	NN
cord-275730-650sjwyy	161	13	surfactant	surfactant	NN
cord-275730-650sjwyy	161	14	encapsulating	encapsulate	VBG
cord-275730-650sjwyy	161	15	the	the	DT
cord-275730-650sjwyy	161	16	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	161	17	(	(	-LRB-
cord-275730-650sjwyy	161	18	PS	PS	NNP
cord-275730-650sjwyy	161	19	-	-	HYPH
cord-275730-650sjwyy	161	20	GAMP	GAMP	NNP
cord-275730-650sjwyy	161	21	)	)	-RRB-
cord-275730-650sjwyy	162	1	Perth	Perth	NNP
cord-275730-650sjwyy	162	2	H3N2	H3N2	NNP
cord-275730-650sjwyy	162	3	vaccine	vaccine	NN
cord-275730-650sjwyy	162	4	[	[	-LRB-
cord-275730-650sjwyy	162	5	10	10	CD
cord-275730-650sjwyy	162	6	]	]	-RRB-
cord-275730-650sjwyy	162	7	.	.	.
cord-275730-650sjwyy	163	1	The	the	DT
cord-275730-650sjwyy	163	2	PS	PS	NNP
cord-275730-650sjwyy	163	3	-	-	HYPH
cord-275730-650sjwyy	163	4	GAMP	GAMP	NNP
cord-275730-650sjwyy	163	5	adjuvanted	adjuvante	VBD
cord-275730-650sjwyy	163	6	flu	flu	NN
cord-275730-650sjwyy	163	7	vaccine	vaccine	NN
cord-275730-650sjwyy	163	8	(	(	-LRB-
cord-275730-650sjwyy	163	9	i.n	i.n	NNP
cord-275730-650sjwyy	163	10	.	.	NNP
cord-275730-650sjwyy	163	11	)	)	-RRB-
cord-275730-650sjwyy	163	12	provided	provide	VBD
cord-275730-650sjwyy	163	13	heterotypic	heterotypic	NNP
cord-275730-650sjwyy	163	14	cross	cross	NNP
cord-275730-650sjwyy	163	15	-	-	NN
cord-275730-650sjwyy	163	16	protection	protection	NN
cord-275730-650sjwyy	163	17	against	against	IN
cord-275730-650sjwyy	163	18	the	the	DT
cord-275730-650sjwyy	163	19	Michigan15	Michigan15	NNP
cord-275730-650sjwyy	164	1	H1N1	H1N1	NNP
cord-275730-650sjwyy	164	2	strain	strain	VBP
cord-275730-650sjwyy	164	3	30	30	CD
cord-275730-650sjwyy	164	4	days	day	NNS
cord-275730-650sjwyy	164	5	post	post	NN
cord-275730-650sjwyy	164	6	-	-	NN
cord-275730-650sjwyy	164	7	immunization	immunization	NN
cord-275730-650sjwyy	164	8	in	in	IN
cord-275730-650sjwyy	164	9	ferrets	ferret	NNS
cord-275730-650sjwyy	164	10	[	[	-LRB-
cord-275730-650sjwyy	164	11	10	10	CD
cord-275730-650sjwyy	164	12	]	]	-RRB-
cord-275730-650sjwyy	164	13	.	.	.
cord-275730-650sjwyy	165	1	These	these	DT
cord-275730-650sjwyy	165	2	biomimetic	biomimetic	JJ
cord-275730-650sjwyy	165	3	liposomes	liposome	NNS
cord-275730-650sjwyy	165	4	activated	activate	VBD
cord-275730-650sjwyy	165	5	STING	sting	NN
cord-275730-650sjwyy	165	6	pathways	pathway	NNS
cord-275730-650sjwyy	165	7	in	in	IN
cord-275730-650sjwyy	165	8	both	both	DT
cord-275730-650sjwyy	165	9	alveolar	alveolar	JJ
cord-275730-650sjwyy	165	10	macrophages	macrophage	NNS
cord-275730-650sjwyy	165	11	and	and	CC
cord-275730-650sjwyy	165	12	alveolar	alveolar	JJ
cord-275730-650sjwyy	165	13	epithelial	epithelial	JJ
cord-275730-650sjwyy	165	14	cells	cell	NNS
cord-275730-650sjwyy	165	15	and	and	CC
cord-275730-650sjwyy	165	16	enhanced	enhance	VBD
cord-275730-650sjwyy	165	17	the	the	DT
cord-275730-650sjwyy	165	18	recruitment	recruitment	NN
cord-275730-650sjwyy	165	19	of	of	IN
cord-275730-650sjwyy	165	20	CD11b	CD11b	NNPS
cord-275730-650sjwyy	165	21	+	+	CC
cord-275730-650sjwyy	165	22	DC	DC	NNP
cord-275730-650sjwyy	165	23	and	and	CC
cord-275730-650sjwyy	165	24	the	the	DT
cord-275730-650sjwyy	165	25	differentiation	differentiation	NN
cord-275730-650sjwyy	165	26	of	of	IN
cord-275730-650sjwyy	165	27	CD8	CD8	NNP
cord-275730-650sjwyy	165	28	+	+	CC
cord-275730-650sjwyy	165	29	T	T	NNP
cord-275730-650sjwyy	165	30	cell	cell	NN
cord-275730-650sjwyy	165	31	and	and	CC
cord-275730-650sjwyy	165	32	humoral	humoral	JJ
cord-275730-650sjwyy	165	33	response	response	NN
cord-275730-650sjwyy	165	34	[	[	-LRB-
cord-275730-650sjwyy	165	35	10	10	CD
cord-275730-650sjwyy	165	36	]	]	-RRB-
cord-275730-650sjwyy	165	37	.	.	.
cord-275730-650sjwyy	166	1	It	-PRON-	PRP
cord-275730-650sjwyy	166	2	generated	generate	VBD
cord-275730-650sjwyy	166	3	heterotypic	heterotypic	NNP
cord-275730-650sjwyy	166	4	protection	protection	NN
cord-275730-650sjwyy	166	5	against	against	IN
cord-275730-650sjwyy	166	6	H3N2	H3N2	NNP
cord-275730-650sjwyy	166	7	,	,	,
cord-275730-650sjwyy	166	8	H5N1	H5N1	NNP
cord-275730-650sjwyy	166	9	,	,	,
cord-275730-650sjwyy	166	10	H7N9	H7N9	NNP
cord-275730-650sjwyy	166	11	viruses	virus	NNS
cord-275730-650sjwyy	166	12	as	as	RB
cord-275730-650sjwyy	166	13	early	early	RB
cord-275730-650sjwyy	166	14	as	as	IN
cord-275730-650sjwyy	166	15	two	two	CD
cord-275730-650sjwyy	166	16	days	day	NNS
cord-275730-650sjwyy	166	17	after	after	IN
cord-275730-650sjwyy	166	18	a	a	DT
cord-275730-650sjwyy	166	19	single	single	JJ
cord-275730-650sjwyy	166	20	dose	dose	NN
cord-275730-650sjwyy	166	21	of	of	IN
cord-275730-650sjwyy	166	22	immunization	immunization	NN
cord-275730-650sjwyy	166	23	and	and	CC
cord-275730-650sjwyy	166	24	promoted	promote	VBD
cord-275730-650sjwyy	166	25	the	the	DT
cord-275730-650sjwyy	166	26	formation	formation	NN
cord-275730-650sjwyy	166	27	of	of	IN
cord-275730-650sjwyy	166	28	a	a	DT
cord-275730-650sjwyy	166	29	durable	durable	JJ
cord-275730-650sjwyy	166	30	CD8	CD8	NNP
cord-275730-650sjwyy	166	31	+	+	CC
cord-275730-650sjwyy	166	32	Trm	Trm	NNP
cord-275730-650sjwyy	166	33	in	in	IN
cord-275730-650sjwyy	166	34	mice	mouse	NNS
cord-275730-650sjwyy	166	35	[	[	-LRB-
cord-275730-650sjwyy	166	36	10	10	CD
cord-275730-650sjwyy	166	37	]	]	-RRB-
cord-275730-650sjwyy	166	38	.	.	.
cord-275730-650sjwyy	167	1	Schulz	Schulz	NNP
cord-275730-650sjwyy	167	2	et	et	NNP
cord-275730-650sjwyy	167	3	al	al	NNP
cord-275730-650sjwyy	167	4	.	.	NNP
cord-275730-650sjwyy	167	5	demonstrated	demonstrate	VBD
cord-275730-650sjwyy	167	6	that	that	IN
cord-275730-650sjwyy	167	7	administering	administer	VBG
cord-275730-650sjwyy	167	8	the	the	DT
cord-275730-650sjwyy	167	9	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	167	10	/	/	SYM
cord-275730-650sjwyy	167	11	dextran	dextran	NN
cord-275730-650sjwyy	167	12	microparticle	microparticle	NNP
cord-275730-650sjwyy	167	13	(	(	-LRB-
cord-275730-650sjwyy	167	14	10	10	CD
cord-275730-650sjwyy	167	15	µg	µg	NN
cord-275730-650sjwyy	167	16	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	167	17	)	)	-RRB-
cord-275730-650sjwyy	168	1	via	via	IN
cord-275730-650sjwyy	169	1	i.t	i.t	NNP
cord-275730-650sjwyy	169	2	.	.	NNP
cord-275730-650sjwyy	169	3	or	or	CC
cord-275730-650sjwyy	169	4	i.v	i.v	NNP
cord-275730-650sjwyy	169	5	.	.	NNP
cord-275730-650sjwyy	169	6	,	,	,
cord-275730-650sjwyy	169	7	i.m	i.m	NNP
cord-275730-650sjwyy	169	8	.	.	NNP
cord-275730-650sjwyy	169	9	,	,	,
cord-275730-650sjwyy	169	10	or	or	CC
cord-275730-650sjwyy	169	11	s.c	s.c	NNP
cord-275730-650sjwyy	169	12	.	.	NNP
cord-275730-650sjwyy	169	13	routes	route	NNS
cord-275730-650sjwyy	169	14	significantly	significantly	RB
cord-275730-650sjwyy	169	15	decreased	decrease	VBD
cord-275730-650sjwyy	169	16	the	the	DT
cord-275730-650sjwyy	169	17	B16F10	b16f10	JJ
cord-275730-650sjwyy	169	18	myeloma	myeloma	NN
cord-275730-650sjwyy	169	19	tumor	tumor	NN
cord-275730-650sjwyy	169	20	size	size	NN
cord-275730-650sjwyy	169	21	in	in	IN
cord-275730-650sjwyy	169	22	mice	mouse	NNS
cord-275730-650sjwyy	169	23	[	[	-LRB-
cord-275730-650sjwyy	169	24	57	57	CD
cord-275730-650sjwyy	169	25	]	]	-RRB-
cord-275730-650sjwyy	169	26	.	.	.
cord-275730-650sjwyy	170	1	A	a	DT
cord-275730-650sjwyy	170	2	100	100	CD
cord-275730-650sjwyy	170	3	ng	ng	NN
cord-275730-650sjwyy	170	4	of	of	IN
cord-275730-650sjwyy	170	5	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	170	6	/	/	SYM
cord-275730-650sjwyy	170	7	dextran	dextran	NN
cord-275730-650sjwyy	170	8	microparticle	microparticle	NNP
cord-275730-650sjwyy	170	9	(	(	-LRB-
cord-275730-650sjwyy	170	10	i.t	i.t	NNP
cord-275730-650sjwyy	170	11	.	.	NNP
cord-275730-650sjwyy	170	12	)	)	-RRB-
cord-275730-650sjwyy	170	13	was	be	VBD
cord-275730-650sjwyy	170	14	sufficient	sufficient	JJ
cord-275730-650sjwyy	170	15	to	to	TO
cord-275730-650sjwyy	170	16	reduce	reduce	VB
cord-275730-650sjwyy	170	17	the	the	DT
cord-275730-650sjwyy	170	18	tumor	tumor	NN
cord-275730-650sjwyy	170	19	size	size	NN
cord-275730-650sjwyy	170	20	as	as	IN
cord-275730-650sjwyy	170	21	compared	compare	VBN
cord-275730-650sjwyy	170	22	to	to	IN
cord-275730-650sjwyy	170	23	the	the	DT
cord-275730-650sjwyy	170	24	soluble	soluble	JJ
cord-275730-650sjwyy	170	25	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	170	26	,	,	,
cord-275730-650sjwyy	170	27	which	which	WDT
cord-275730-650sjwyy	170	28	had	have	VBD
cord-275730-650sjwyy	170	29	to	to	TO
cord-275730-650sjwyy	170	30	be	be	VB
cord-275730-650sjwyy	170	31	immunized	immunize	VBN
cord-275730-650sjwyy	170	32	at	at	IN
cord-275730-650sjwyy	170	33	a	a	DT
cord-275730-650sjwyy	170	34	10×	10×	CD
cord-275730-650sjwyy	170	35	higher	high	JJR
cord-275730-650sjwyy	170	36	concentration	concentration	NN
cord-275730-650sjwyy	170	37	to	to	TO
cord-275730-650sjwyy	170	38	obtain	obtain	VB
cord-275730-650sjwyy	170	39	the	the	DT
cord-275730-650sjwyy	170	40	same	same	JJ
cord-275730-650sjwyy	170	41	effect	effect	NN
cord-275730-650sjwyy	170	42	[	[	-LRB-
cord-275730-650sjwyy	170	43	57	57	CD
cord-275730-650sjwyy	170	44	]	]	-RRB-
cord-275730-650sjwyy	170	45	.	.	.
cord-275730-650sjwyy	171	1	Liposomes	liposome	NNS
cord-275730-650sjwyy	171	2	composed	compose	VBN
cord-275730-650sjwyy	171	3	of	of	IN
cord-275730-650sjwyy	171	4	a	a	DT
cord-275730-650sjwyy	171	5	phospholipid	phospholipid	NN
cord-275730-650sjwyy	171	6	bilayer	bilayer	NN
cord-275730-650sjwyy	171	7	can	can	MD
cord-275730-650sjwyy	171	8	easily	easily	RB
cord-275730-650sjwyy	171	9	penetrate	penetrate	VB
cord-275730-650sjwyy	171	10	the	the	DT
cord-275730-650sjwyy	171	11	cell	cell	NN
cord-275730-650sjwyy	171	12	membrane	membrane	NN
cord-275730-650sjwyy	171	13	.	.	.
cord-275730-650sjwyy	172	1	Miyabe	Miyabe	NNP
cord-275730-650sjwyy	172	2	et	et	NNP
cord-275730-650sjwyy	172	3	al	al	NNP
cord-275730-650sjwyy	172	4	.	.	NNP
cord-275730-650sjwyy	172	5	synthesized	synthesize	VBD
cord-275730-650sjwyy	172	6	a	a	DT
cord-275730-650sjwyy	172	7	pH	ph	JJ
cord-275730-650sjwyy	172	8	-	-	JJ
cord-275730-650sjwyy	172	9	sensitive	sensitive	JJ
cord-275730-650sjwyy	172	10	synthetic	synthetic	JJ
cord-275730-650sjwyy	172	11	lipid	lipid	NN
cord-275730-650sjwyy	172	12	YSK05	ysk05	NN
cord-275730-650sjwyy	172	13	for	for	IN
cord-275730-650sjwyy	172	14	cytosolic	cytosolic	JJ
cord-275730-650sjwyy	172	15	delivery	delivery	NN
cord-275730-650sjwyy	172	16	of	of	IN
cord-275730-650sjwyy	172	17	CDG	CDG	NNP
cord-275730-650sjwyy	172	18	as	as	IN
cord-275730-650sjwyy	172	19	a	a	DT
cord-275730-650sjwyy	172	20	result	result	NN
cord-275730-650sjwyy	172	21	of	of	IN
cord-275730-650sjwyy	172	22	the	the	DT
cord-275730-650sjwyy	172	23	high	high	JJ
cord-275730-650sjwyy	172	24	fusogenic	fusogenic	JJ
cord-275730-650sjwyy	172	25	property	property	NN
cord-275730-650sjwyy	172	26	of	of	IN
cord-275730-650sjwyy	172	27	the	the	DT
cord-275730-650sjwyy	172	28	lipid	lipid	NN
cord-275730-650sjwyy	172	29	vesicle	vesicle	NN
cord-275730-650sjwyy	172	30	at	at	IN
cord-275730-650sjwyy	172	31	acidic	acidic	JJ
cord-275730-650sjwyy	172	32	pH	pH	NNP
cord-275730-650sjwyy	172	33	[	[	-LRB-
cord-275730-650sjwyy	172	34	61	61	CD
cord-275730-650sjwyy	172	35	]	]	-RRB-
cord-275730-650sjwyy	172	36	.	.	.
cord-275730-650sjwyy	173	1	In	in	IN
cord-275730-650sjwyy	173	2	a	a	DT
cord-275730-650sjwyy	173	3	mouse	mouse	NN
cord-275730-650sjwyy	173	4	model	model	NN
cord-275730-650sjwyy	173	5	infected	infect	VBN
cord-275730-650sjwyy	173	6	with	with	IN
cord-275730-650sjwyy	173	7	EG7-OVA	EG7-OVA	NNP
cord-275730-650sjwyy	173	8	cells	cell	NNS
cord-275730-650sjwyy	173	9	,	,	,
cord-275730-650sjwyy	173	10	s.c	s.c	NNP
cord-275730-650sjwyy	173	11	.	.	NNP
cord-275730-650sjwyy	173	12	immunization	immunization	NN
cord-275730-650sjwyy	173	13	of	of	IN
cord-275730-650sjwyy	173	14	liposome	liposome	NN
cord-275730-650sjwyy	173	15	/	/	SYM
cord-275730-650sjwyy	173	16	CDG	CDG	NNP
cord-275730-650sjwyy	173	17	(	(	-LRB-
cord-275730-650sjwyy	173	18	300	300	CD
cord-275730-650sjwyy	173	19	ng	ng	NN
cord-275730-650sjwyy	173	20	)	)	-RRB-
cord-275730-650sjwyy	173	21	completely	completely	RB
cord-275730-650sjwyy	173	22	inhibited	inhibit	VBN
cord-275730-650sjwyy	173	23	tumor	tumor	NN
cord-275730-650sjwyy	173	24	growth	growth	NN
cord-275730-650sjwyy	173	25	while	while	IN
cord-275730-650sjwyy	173	26	the	the	DT
cord-275730-650sjwyy	173	27	soluble	soluble	JJ
cord-275730-650sjwyy	173	28	CDG	CDG	NNP
cord-275730-650sjwyy	173	29	could	could	MD
cord-275730-650sjwyy	173	30	not	not	RB
cord-275730-650sjwyy	173	31	restrict	restrict	VB
cord-275730-650sjwyy	173	32	tumor	tumor	NN
cord-275730-650sjwyy	173	33	growth	growth	NN
cord-275730-650sjwyy	173	34	[	[	-LRB-
cord-275730-650sjwyy	173	35	61	61	CD
cord-275730-650sjwyy	173	36	]	]	-RRB-
cord-275730-650sjwyy	173	37	.	.	.
cord-275730-650sjwyy	174	1	A	a	DT
cord-275730-650sjwyy	174	2	similar	similar	JJ
cord-275730-650sjwyy	174	3	study	study	NN
cord-275730-650sjwyy	174	4	using	use	VBG
cord-275730-650sjwyy	174	5	cationic	cationic	JJ
cord-275730-650sjwyy	174	6	PEGylated	pegylated	JJ
cord-275730-650sjwyy	174	7	liposome	liposome	NN
cord-275730-650sjwyy	174	8	and	and	CC
cord-275730-650sjwyy	174	9	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	174	10	was	be	VBD
cord-275730-650sjwyy	174	11	evaluated	evaluate	VBN
cord-275730-650sjwyy	174	12	against	against	IN
cord-275730-650sjwyy	174	13	metastatic	metastatic	JJ
cord-275730-650sjwyy	174	14	lung	lung	NN
cord-275730-650sjwyy	174	15	tumors	tumor	NNS
cord-275730-650sjwyy	174	16	in	in	IN
cord-275730-650sjwyy	174	17	the	the	DT
cord-275730-650sjwyy	174	18	B16F10	b16f10	JJ
cord-275730-650sjwyy	174	19	melanoma	melanoma	NN
cord-275730-650sjwyy	174	20	mode	mode	NN
cord-275730-650sjwyy	174	21	[	[	-LRB-
cord-275730-650sjwyy	174	22	64	64	CD
cord-275730-650sjwyy	174	23	]	]	-RRB-
cord-275730-650sjwyy	174	24	.	.	.
cord-275730-650sjwyy	175	1	Intravenous	intravenous	JJ
cord-275730-650sjwyy	175	2	injection	injection	NN
cord-275730-650sjwyy	175	3	of	of	IN
cord-275730-650sjwyy	175	4	liposome	liposome	NN
cord-275730-650sjwyy	175	5	/	/	SYM
cord-275730-650sjwyy	175	6	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	175	7	in	in	IN
cord-275730-650sjwyy	175	8	tumor	tumor	NN
cord-275730-650sjwyy	175	9	-	-	HYPH
cord-275730-650sjwyy	175	10	bearing	bear	VBG
cord-275730-650sjwyy	175	11	mice	mouse	NNS
cord-275730-650sjwyy	175	12	led	lead	VBD
cord-275730-650sjwyy	175	13	to	to	IN
cord-275730-650sjwyy	175	14	over	over	IN
cord-275730-650sjwyy	175	15	200-fold	200-fold	CD
cord-275730-650sjwyy	175	16	increase	increase	NN
cord-275730-650sjwyy	175	17	of	of	IN
cord-275730-650sjwyy	175	18	lung	lung	NN
cord-275730-650sjwyy	175	19	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	175	20	[	[	-LRB-
cord-275730-650sjwyy	175	21	64	64	CD
cord-275730-650sjwyy	175	22	]	]	-RRB-
cord-275730-650sjwyy	175	23	.	.	.
cord-275730-650sjwyy	176	1	Liposome	liposome	NN
cord-275730-650sjwyy	176	2	/	/	SYM
cord-275730-650sjwyy	176	3	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	176	4	treated	treat	VBN
cord-275730-650sjwyy	176	5	mice	mouse	NNS
cord-275730-650sjwyy	176	6	showed	show	VBD
cord-275730-650sjwyy	176	7	a	a	DT
cord-275730-650sjwyy	176	8	significantly	significantly	RB
cord-275730-650sjwyy	176	9	reduced	reduce	VBN
cord-275730-650sjwyy	176	10	median	median	JJ
cord-275730-650sjwyy	176	11	tumor	tumor	NN
cord-275730-650sjwyy	176	12	nodule	nodule	NN
cord-275730-650sjwyy	176	13	length	length	NN
cord-275730-650sjwyy	176	14	in	in	IN
cord-275730-650sjwyy	176	15	the	the	DT
cord-275730-650sjwyy	176	16	lung	lung	NN
cord-275730-650sjwyy	176	17	when	when	WRB
cord-275730-650sjwyy	176	18	compared	compare	VBN
cord-275730-650sjwyy	176	19	to	to	IN
cord-275730-650sjwyy	176	20	PBS	PBS	NNP
cord-275730-650sjwyy	176	21	-	-	HYPH
cord-275730-650sjwyy	176	22	treated	treat	VBN
cord-275730-650sjwyy	176	23	controls	control	NNS
cord-275730-650sjwyy	176	24	[	[	-LRB-
cord-275730-650sjwyy	176	25	64	64	CD
cord-275730-650sjwyy	176	26	]	]	-RRB-
cord-275730-650sjwyy	176	27	.	.	.
cord-275730-650sjwyy	177	1	In	in	IN
cord-275730-650sjwyy	177	2	comparison	comparison	NN
cord-275730-650sjwyy	177	3	,	,	,
cord-275730-650sjwyy	177	4	free	free	JJ
cord-275730-650sjwyy	177	5	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	177	6	treated	treat	VBN
cord-275730-650sjwyy	177	7	mice	mouse	NNS
cord-275730-650sjwyy	177	8	failed	fail	VBD
cord-275730-650sjwyy	177	9	to	to	TO
cord-275730-650sjwyy	177	10	reduce	reduce	VB
cord-275730-650sjwyy	177	11	the	the	DT
cord-275730-650sjwyy	177	12	tumor	tumor	NN
cord-275730-650sjwyy	177	13	length	length	NN
cord-275730-650sjwyy	177	14	[	[	-LRB-
cord-275730-650sjwyy	177	15	64	64	CD
cord-275730-650sjwyy	177	16	]	]	-RRB-
cord-275730-650sjwyy	177	17	.	.	.
cord-275730-650sjwyy	178	1	Furthermore	furthermore	RB
cord-275730-650sjwyy	178	2	,	,	,
cord-275730-650sjwyy	178	3	liposome	liposome	NN
cord-275730-650sjwyy	178	4	/	/	SYM
cord-275730-650sjwyy	178	5	cGAMP	cgamp	NN
cord-275730-650sjwyy	178	6	formulation	formulation	NN
cord-275730-650sjwyy	178	7	generated	generate	VBD
cord-275730-650sjwyy	178	8	tumor	tumor	NN
cord-275730-650sjwyy	178	9	-	-	HYPH
cord-275730-650sjwyy	178	10	specific	specific	JJ
cord-275730-650sjwyy	178	11	memory	memory	NN
cord-275730-650sjwyy	178	12	and	and	CC
cord-275730-650sjwyy	178	13	provided	provide	VBD
cord-275730-650sjwyy	178	14	nearly	nearly	RB
cord-275730-650sjwyy	178	15	total	total	JJ
cord-275730-650sjwyy	178	16	protection	protection	NN
cord-275730-650sjwyy	178	17	against	against	IN
cord-275730-650sjwyy	178	18	re	re	NN
cord-275730-650sjwyy	178	19	-	-	NN
cord-275730-650sjwyy	178	20	challenge	challenge	VB
cord-275730-650sjwyy	178	21	even	even	RB
cord-275730-650sjwyy	178	22	after	after	IN
cord-275730-650sjwyy	178	23	60	60	CD
cord-275730-650sjwyy	178	24	days	day	NNS
cord-275730-650sjwyy	178	25	of	of	IN
cord-275730-650sjwyy	178	26	treatment	treatment	NN
cord-275730-650sjwyy	178	27	[	[	-LRB-
cord-275730-650sjwyy	178	28	64	64	CD
cord-275730-650sjwyy	178	29	]	]	-RRB-
cord-275730-650sjwyy	178	30	.	.	.
cord-275730-650sjwyy	179	1	Separately	separately	RB
cord-275730-650sjwyy	179	2	,	,	,
cord-275730-650sjwyy	179	3	in	in	IN
cord-275730-650sjwyy	179	4	a	a	DT
cord-275730-650sjwyy	179	5	B16.F10	B16.F10	NNP
cord-275730-650sjwyy	179	6	melanoma	melanoma	NN
cord-275730-650sjwyy	179	7	model	model	NN
cord-275730-650sjwyy	179	8	,	,	,
cord-275730-650sjwyy	179	9	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	179	10	encapsulating	encapsulate	VBG
cord-275730-650sjwyy	180	1	PEG	peg	NN
cord-275730-650sjwyy	180	2	-	-	HYPH
cord-275730-650sjwyy	180	3	DBP	dbp	NN
cord-275730-650sjwyy	180	4	pH	ph	NN
cord-275730-650sjwyy	180	5	-	-	HYPH
cord-275730-650sjwyy	180	6	responsive	responsive	JJ
cord-275730-650sjwyy	180	7	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	180	8	enhanced	enhance	VBN
cord-275730-650sjwyy	180	9	STING	sting	NN
cord-275730-650sjwyy	180	10	signaling	signal	VBG
cord-275730-650sjwyy	180	11	in	in	IN
cord-275730-650sjwyy	180	12	the	the	DT
cord-275730-650sjwyy	180	13	tumor	tumor	NN
cord-275730-650sjwyy	180	14	microenvironment	microenvironment	NN
cord-275730-650sjwyy	180	15	(	(	-LRB-
cord-275730-650sjwyy	180	16	TME	TME	NNP
cord-275730-650sjwyy	180	17	)	)	-RRB-
cord-275730-650sjwyy	180	18	[	[	-LRB-
cord-275730-650sjwyy	180	19	63	63	CD
cord-275730-650sjwyy	180	20	]	]	-RRB-
cord-275730-650sjwyy	180	21	.	.	.
cord-275730-650sjwyy	181	1	A	a	DT
cord-275730-650sjwyy	181	2	single	single	JJ
cord-275730-650sjwyy	181	3	intratumoral	intratumoral	JJ
cord-275730-650sjwyy	181	4	administration	administration	NN
cord-275730-650sjwyy	181	5	of	of	IN
cord-275730-650sjwyy	181	6	polymersome	polymersome	NNP
cord-275730-650sjwyy	181	7	encapsulated	encapsulate	VBN
cord-275730-650sjwyy	181	8	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	181	9	increased	increase	VBN
cord-275730-650sjwyy	181	10	neutrophil	neutrophil	NN
cord-275730-650sjwyy	181	11	infiltration	infiltration	NN
cord-275730-650sjwyy	181	12	,	,	,
cord-275730-650sjwyy	181	13	reduced	reduce	VBN
cord-275730-650sjwyy	181	14	macrophages	macrophage	NNS
cord-275730-650sjwyy	181	15	immunosuppressive	immunosuppressive	JJ
cord-275730-650sjwyy	181	16	capacity	capacity	NN
cord-275730-650sjwyy	181	17	,	,	,
cord-275730-650sjwyy	181	18	and	and	CC
cord-275730-650sjwyy	181	19	increased	increase	VBD
cord-275730-650sjwyy	181	20	DC	DC	NNP
cord-275730-650sjwyy	181	21	activation	activation	NN
cord-275730-650sjwyy	181	22	in	in	IN
cord-275730-650sjwyy	181	23	the	the	DT
cord-275730-650sjwyy	181	24	TME	TME	NNP
cord-275730-650sjwyy	181	25	[	[	-LRB-
cord-275730-650sjwyy	181	26	63	63	CD
cord-275730-650sjwyy	181	27	]	]	-RRB-
cord-275730-650sjwyy	181	28	.	.	.
cord-275730-650sjwyy	182	1	In	in	IN
cord-275730-650sjwyy	182	2	contract	contract	NN
cord-275730-650sjwyy	182	3	,	,	,
cord-275730-650sjwyy	182	4	mixing	mix	VBG
cord-275730-650sjwyy	182	5	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	182	6	with	with	IN
cord-275730-650sjwyy	182	7	the	the	DT
cord-275730-650sjwyy	182	8	pre	pre	JJ
cord-275730-650sjwyy	182	9	-	-	JJ
cord-275730-650sjwyy	182	10	formulated	formulate	VBN
cord-275730-650sjwyy	182	11	vesicle	vesicle	NN
cord-275730-650sjwyy	182	12	did	do	VBD
cord-275730-650sjwyy	182	13	not	not	RB
cord-275730-650sjwyy	182	14	have	have	VB
cord-275730-650sjwyy	182	15	any	any	DT
cord-275730-650sjwyy	182	16	immunomodulatory	immunomodulatory	JJ
cord-275730-650sjwyy	182	17	effect	effect	NN
cord-275730-650sjwyy	182	18	[	[	-LRB-
cord-275730-650sjwyy	182	19	63	63	CD
cord-275730-650sjwyy	182	20	]	]	-RRB-
cord-275730-650sjwyy	182	21	.	.	.
cord-275730-650sjwyy	183	1	The	the	DT
cord-275730-650sjwyy	183	2	polymersome	polymersome	NN
cord-275730-650sjwyy	183	3	encapsulated	encapsulate	VBN
cord-275730-650sjwyy	183	4	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	183	5	resulted	result	VBD
cord-275730-650sjwyy	183	6	in	in	IN
cord-275730-650sjwyy	183	7	an	an	DT
cord-275730-650sjwyy	183	8	11-fold	11-fold	CD
cord-275730-650sjwyy	183	9	decrease	decrease	NN
cord-275730-650sjwyy	183	10	in	in	IN
cord-275730-650sjwyy	183	11	tumor	tumor	NN
cord-275730-650sjwyy	183	12	growth	growth	NN
cord-275730-650sjwyy	183	13	[	[	-LRB-
cord-275730-650sjwyy	183	14	63	63	CD
cord-275730-650sjwyy	183	15	]	]	-RRB-
cord-275730-650sjwyy	183	16	.	.	.
cord-275730-650sjwyy	184	1	The	the	DT
cord-275730-650sjwyy	184	2	intravenous	intravenous	JJ
cord-275730-650sjwyy	184	3	administration	administration	NN
cord-275730-650sjwyy	184	4	of	of	IN
cord-275730-650sjwyy	184	5	polymersome	polymersome	NNP
cord-275730-650sjwyy	184	6	encapsulated	encapsulate	VBN
cord-275730-650sjwyy	184	7	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	184	8	reduced	reduce	VBD
cord-275730-650sjwyy	184	9	the	the	DT
cord-275730-650sjwyy	184	10	doubling	double	VBG
cord-275730-650sjwyy	184	11	time	time	NN
cord-275730-650sjwyy	184	12	(	(	-LRB-
cord-275730-650sjwyy	184	13	DT	DT	NNP
cord-275730-650sjwyy	184	14	)	)	-RRB-
cord-275730-650sjwyy	184	15	by	by	IN
cord-275730-650sjwyy	184	16	50	50	CD
cord-275730-650sjwyy	184	17	%	%	NN
cord-275730-650sjwyy	184	18	[	[	-LRB-
cord-275730-650sjwyy	184	19	63	63	CD
cord-275730-650sjwyy	184	20	]	]	-RRB-
cord-275730-650sjwyy	184	21	.	.	.
cord-275730-650sjwyy	185	1	Combinatorial	combinatorial	JJ
cord-275730-650sjwyy	185	2	administration	administration	NN
cord-275730-650sjwyy	185	3	of	of	IN
cord-275730-650sjwyy	185	4	the	the	DT
cord-275730-650sjwyy	185	5	formulation	formulation	NN
cord-275730-650sjwyy	185	6	with	with	IN
cord-275730-650sjwyy	185	7	an	an	DT
cord-275730-650sjwyy	185	8	immune	immune	JJ
cord-275730-650sjwyy	185	9	checkpoint	checkpoint	NN
cord-275730-650sjwyy	185	10	blockade	blockade	NN
cord-275730-650sjwyy	185	11	further	further	RB
cord-275730-650sjwyy	185	12	reduced	reduce	VBD
cord-275730-650sjwyy	185	13	the	the	DT
cord-275730-650sjwyy	185	14	DT	dt	NN
cord-275730-650sjwyy	185	15	by	by	IN
cord-275730-650sjwyy	185	16	40	40	CD
cord-275730-650sjwyy	185	17	%	%	NN
cord-275730-650sjwyy	185	18	.	.	.
cord-275730-650sjwyy	186	1	Importantly	importantly	RB
cord-275730-650sjwyy	186	2	,	,	,
cord-275730-650sjwyy	186	3	the	the	DT
cord-275730-650sjwyy	186	4	mice	mouse	NNS
cord-275730-650sjwyy	186	5	that	that	WDT
cord-275730-650sjwyy	186	6	received	receive	VBD
cord-275730-650sjwyy	186	7	combinatorial	combinatorial	JJ
cord-275730-650sjwyy	186	8	therapy	therapy	NN
cord-275730-650sjwyy	186	9	exhibited	exhibit	VBD
cord-275730-650sjwyy	186	10	no	no	DT
cord-275730-650sjwyy	186	11	evidence	evidence	NN
cord-275730-650sjwyy	186	12	of	of	IN
cord-275730-650sjwyy	186	13	tumor	tumor	NN
cord-275730-650sjwyy	186	14	burden	burden	NN
cord-275730-650sjwyy	186	15	even	even	RB
cord-275730-650sjwyy	186	16	after	after	IN
cord-275730-650sjwyy	186	17	55	55	CD
cord-275730-650sjwyy	186	18	days	day	NNS
cord-275730-650sjwyy	186	19	of	of	IN
cord-275730-650sjwyy	186	20	treatment	treatment	NN
cord-275730-650sjwyy	186	21	[	[	-LRB-
cord-275730-650sjwyy	186	22	63	63	CD
cord-275730-650sjwyy	186	23	]	]	-RRB-
cord-275730-650sjwyy	186	24	.	.	.
cord-275730-650sjwyy	187	1	Finally	finally	RB
cord-275730-650sjwyy	187	2	,	,	,
cord-275730-650sjwyy	187	3	intratumoral	intratumoral	JJ
cord-275730-650sjwyy	187	4	administration	administration	NN
cord-275730-650sjwyy	187	5	of	of	IN
cord-275730-650sjwyy	187	6	the	the	DT
cord-275730-650sjwyy	187	7	polymersome	polymersome	NNP
cord-275730-650sjwyy	187	8	encapsulated	encapsulate	VBN
cord-275730-650sjwyy	187	9	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	187	10	did	do	VBD
cord-275730-650sjwyy	187	11	not	not	RB
cord-275730-650sjwyy	187	12	cause	cause	VB
cord-275730-650sjwyy	187	13	any	any	DT
cord-275730-650sjwyy	187	14	organ	organ	NN
cord-275730-650sjwyy	187	15	cytotoxicity	cytotoxicity	NN
cord-275730-650sjwyy	187	16	[	[	-LRB-
cord-275730-650sjwyy	187	17	63	63	CD
cord-275730-650sjwyy	187	18	]	]	-RRB-
cord-275730-650sjwyy	187	19	.	.	.
cord-275730-650sjwyy	188	1	Intratumoral	intratumoral	JJ
cord-275730-650sjwyy	188	2	injection	injection	NN
cord-275730-650sjwyy	188	3	of	of	IN
cord-275730-650sjwyy	188	4	immunostimulants	immunostimulant	NNS
cord-275730-650sjwyy	188	5	is	be	VBZ
cord-275730-650sjwyy	188	6	effective	effective	JJ
cord-275730-650sjwyy	188	7	in	in	IN
cord-275730-650sjwyy	188	8	the	the	DT
cord-275730-650sjwyy	188	9	local	local	JJ
cord-275730-650sjwyy	188	10	site	site	NN
cord-275730-650sjwyy	188	11	.	.	.
cord-275730-650sjwyy	189	1	However	however	RB
cord-275730-650sjwyy	189	2	,	,	,
cord-275730-650sjwyy	189	3	it	-PRON-	PRP
cord-275730-650sjwyy	189	4	often	often	RB
cord-275730-650sjwyy	189	5	fails	fail	VBZ
cord-275730-650sjwyy	189	6	to	to	TO
cord-275730-650sjwyy	189	7	generate	generate	VB
cord-275730-650sjwyy	189	8	a	a	DT
cord-275730-650sjwyy	189	9	systemic	systemic	JJ
cord-275730-650sjwyy	189	10	response	response	NN
cord-275730-650sjwyy	189	11	and	and	CC
cord-275730-650sjwyy	189	12	is	be	VBZ
cord-275730-650sjwyy	189	13	ineffective	ineffective	JJ
cord-275730-650sjwyy	189	14	on	on	IN
cord-275730-650sjwyy	189	15	distant	distant	JJ
cord-275730-650sjwyy	189	16	tumor	tumor	NN
cord-275730-650sjwyy	189	17	sites	site	NNS
cord-275730-650sjwyy	189	18	.	.	.
cord-275730-650sjwyy	190	1	Using	use	VBG
cord-275730-650sjwyy	190	2	a	a	DT
cord-275730-650sjwyy	190	3	phosphatidylserine	phosphatidylserine	NN
cord-275730-650sjwyy	190	4	coated	coat	VBN
cord-275730-650sjwyy	190	5	liposome	liposome	NN
cord-275730-650sjwyy	190	6	loaded	load	VBN
cord-275730-650sjwyy	190	7	with	with	IN
cord-275730-650sjwyy	190	8	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	190	9	(	(	-LRB-
cord-275730-650sjwyy	190	10	NP	NP	NNP
cord-275730-650sjwyy	190	11	-	-	HYPH
cord-275730-650sjwyy	190	12	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	190	13	)	)	-RRB-
cord-275730-650sjwyy	191	1	in	in	IN
cord-275730-650sjwyy	191	2	combination	combination	NN
cord-275730-650sjwyy	191	3	with	with	IN
cord-275730-650sjwyy	191	4	radiotherapy	radiotherapy	NN
cord-275730-650sjwyy	191	5	(	(	-LRB-
cord-275730-650sjwyy	191	6	IR	IR	NNP
cord-275730-650sjwyy	191	7	)	)	-RRB-
cord-275730-650sjwyy	191	8	,	,	,
cord-275730-650sjwyy	191	9	Liu	Liu	NNP
cord-275730-650sjwyy	191	10	and	and	CC
cord-275730-650sjwyy	191	11	Y.	Y.	NNP
cord-275730-650sjwyy	191	12	et	et	NNP
cord-275730-650sjwyy	191	13	al	al	NNP
cord-275730-650sjwyy	191	14	.	.	.
cord-275730-650sjwyy	192	1	detected	detect	VBN
cord-275730-650sjwyy	192	2	significantly	significantly	RB
cord-275730-650sjwyy	192	3	elevated	elevated	JJ
cord-275730-650sjwyy	192	4	lung	lung	NN
cord-275730-650sjwyy	192	5	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	192	6	,	,	,
cord-275730-650sjwyy	192	7	and	and	CC
cord-275730-650sjwyy	192	8	TNFα	TNFα	NNS
cord-275730-650sjwyy	192	9	,	,	,
cord-275730-650sjwyy	192	10	IFNγ	IFNγ	NNS
cord-275730-650sjwyy	192	11	,	,	,
cord-275730-650sjwyy	192	12	IL-6	IL-6	NNP
cord-275730-650sjwyy	192	13	,	,	,
cord-275730-650sjwyy	192	14	IL-12p40	IL-12p40	NNP
cord-275730-650sjwyy	192	15	in	in	IN
cord-275730-650sjwyy	192	16	a	a	DT
cord-275730-650sjwyy	192	17	lung	lung	NN
cord-275730-650sjwyy	192	18	metastasis	metastasis	NN
cord-275730-650sjwyy	192	19	mouse	mouse	NN
cord-275730-650sjwyy	192	20	mode	mode	NN
cord-275730-650sjwyy	192	21	[	[	-LRB-
cord-275730-650sjwyy	192	22	66	66	CD
cord-275730-650sjwyy	192	23	]	]	-RRB-
cord-275730-650sjwyy	192	24	.	.	.
cord-275730-650sjwyy	193	1	The	the	DT
cord-275730-650sjwyy	193	2	combinatorial	combinatorial	JJ
cord-275730-650sjwyy	193	3	therapy	therapy	NN
cord-275730-650sjwyy	193	4	inhibited	inhibit	VBN
cord-275730-650sjwyy	193	5	metastases	metastasis	NNS
cord-275730-650sjwyy	193	6	in	in	IN
cord-275730-650sjwyy	193	7	both	both	CC
cord-275730-650sjwyy	193	8	the	the	DT
cord-275730-650sjwyy	193	9	IR	IR	NNP
cord-275730-650sjwyy	193	10	-	-	:
cord-275730-650sjwyy	193	11	and	and	CC
cord-275730-650sjwyy	193	12	non	non	JJ
cord-275730-650sjwyy	193	13	-	-	JJ
cord-275730-650sjwyy	193	14	IR	ir	NN
cord-275730-650sjwyy	193	15	-	-	HYPH
cord-275730-650sjwyy	193	16	treated	treat	VBN
cord-275730-650sjwyy	193	17	lungs	lung	NNS
cord-275730-650sjwyy	193	18	and	and	CC
cord-275730-650sjwyy	193	19	caused	cause	VBD
cord-275730-650sjwyy	193	20	complete	complete	JJ
cord-275730-650sjwyy	193	21	regression	regression	NN
cord-275730-650sjwyy	193	22	of	of	IN
cord-275730-650sjwyy	193	23	lung	lung	NN
cord-275730-650sjwyy	193	24	metastases	metastasis	NNS
cord-275730-650sjwyy	193	25	in	in	IN
cord-275730-650sjwyy	193	26	some	some	DT
cord-275730-650sjwyy	193	27	mice	mouse	NNS
cord-275730-650sjwyy	193	28	[	[	-LRB-
cord-275730-650sjwyy	193	29	66	66	CD
cord-275730-650sjwyy	193	30	]	]	-RRB-
cord-275730-650sjwyy	193	31	.	.	.
cord-275730-650sjwyy	194	1	This	this	DT
cord-275730-650sjwyy	194	2	combinatorial	combinatorial	JJ
cord-275730-650sjwyy	194	3	therapy	therapy	NN
cord-275730-650sjwyy	194	4	also	also	RB
cord-275730-650sjwyy	194	5	promoted	promote	VBD
cord-275730-650sjwyy	194	6	an	an	DT
cord-275730-650sjwyy	194	7	anti	anti	JJ
cord-275730-650sjwyy	194	8	-	-	JJ
cord-275730-650sjwyy	194	9	tumor	tumor	JJ
cord-275730-650sjwyy	194	10	memory	memory	NN
cord-275730-650sjwyy	194	11	response	response	NN
cord-275730-650sjwyy	194	12	[	[	-LRB-
cord-275730-650sjwyy	194	13	66	66	CD
cord-275730-650sjwyy	194	14	]	]	-RRB-
cord-275730-650sjwyy	194	15	.	.	.
cord-275730-650sjwyy	195	1	In	in	IN
cord-275730-650sjwyy	195	2	summary	summary	NN
cord-275730-650sjwyy	195	3	,	,	,
cord-275730-650sjwyy	195	4	CDNs	CDNs	NNP
cord-275730-650sjwyy	195	5	can	can	MD
cord-275730-650sjwyy	195	6	be	be	VB
cord-275730-650sjwyy	195	7	administered	administer	VBN
cord-275730-650sjwyy	195	8	directly	directly	RB
cord-275730-650sjwyy	195	9	via	via	IN
cord-275730-650sjwyy	195	10	i.n	i.n	NNP
cord-275730-650sjwyy	195	11	.	.	NNP
cord-275730-650sjwyy	195	12	,	,	,
cord-275730-650sjwyy	195	13	s.c	s.c	NNP
cord-275730-650sjwyy	195	14	.	.	NNP
cord-275730-650sjwyy	195	15	,	,	,
cord-275730-650sjwyy	195	16	or	or	CC
cord-275730-650sjwyy	195	17	encapsulated	encapsulate	VBN
cord-275730-650sjwyy	195	18	in	in	IN
cord-275730-650sjwyy	195	19	nano	nano	NN
cord-275730-650sjwyy	195	20	/	/	SYM
cord-275730-650sjwyy	195	21	microparticles	microparticle	NNS
cord-275730-650sjwyy	195	22	via	via	IN
cord-275730-650sjwyy	195	23	i.m	i.m	NNP
cord-275730-650sjwyy	195	24	.	.	NNP
cord-275730-650sjwyy	195	25	,	,	,
cord-275730-650sjwyy	195	26	s.c	s.c	NNP
cord-275730-650sjwyy	195	27	.	.	NNP
cord-275730-650sjwyy	195	28	,	,	,
cord-275730-650sjwyy	195	29	i.n	i.n	NNP
cord-275730-650sjwyy	195	30	.	.	NNP
cord-275730-650sjwyy	195	31	,	,	,
cord-275730-650sjwyy	195	32	i.t	i.t	NNP
cord-275730-650sjwyy	195	33	.	.	NNP
cord-275730-650sjwyy	195	34	,	,	,
cord-275730-650sjwyy	195	35	or	or	CC
cord-275730-650sjwyy	195	36	i.v	i.v	NNP
cord-275730-650sjwyy	195	37	.	.	NNP
cord-275730-650sjwyy	195	38	routes	route	NNS
cord-275730-650sjwyy	195	39	.	.	.
cord-275730-650sjwyy	196	1	Encapsulated	encapsulate	VBN
cord-275730-650sjwyy	196	2	CDNs	CDNs	NNP
cord-275730-650sjwyy	196	3	lower	lower	RBR
cord-275730-650sjwyy	196	4	the	the	DT
cord-275730-650sjwyy	196	5	dose	dose	NN
cord-275730-650sjwyy	197	1	(	(	-LRB-
cord-275730-650sjwyy	197	2	>	>	XX
cord-275730-650sjwyy	197	3	10-fold	10-fold	DT
cord-275730-650sjwyy	197	4	less	less	RBR
cord-275730-650sjwyy	197	5	)	)	-RRB-
cord-275730-650sjwyy	198	1	needed	need	VBN
cord-275730-650sjwyy	198	2	to	to	TO
cord-275730-650sjwyy	198	3	induce	induce	VB
cord-275730-650sjwyy	198	4	effective	effective	JJ
cord-275730-650sjwyy	198	5	vaccine	vaccine	NN
cord-275730-650sjwyy	198	6	responses	response	NNS
cord-275730-650sjwyy	198	7	in	in	IN
cord-275730-650sjwyy	198	8	vivo	vivo	NN
cord-275730-650sjwyy	198	9	.	.	.
cord-275730-650sjwyy	199	1	Furthermore	furthermore	RB
cord-275730-650sjwyy	199	2	,	,	,
cord-275730-650sjwyy	199	3	encapsulated	encapsulate	VBN
cord-275730-650sjwyy	199	4	CDNs	CDNs	NNP
cord-275730-650sjwyy	199	5	offer	offer	VBP
cord-275730-650sjwyy	199	6	the	the	DT
cord-275730-650sjwyy	199	7	advantage	advantage	NN
cord-275730-650sjwyy	199	8	of	of	IN
cord-275730-650sjwyy	199	9	long	long	JJ
cord-275730-650sjwyy	199	10	term	term	NN
cord-275730-650sjwyy	199	11	storage	storage	NN
cord-275730-650sjwyy	199	12	upon	upon	IN
cord-275730-650sjwyy	199	13	lyophilization	lyophilization	NN
cord-275730-650sjwyy	199	14	,	,	,
cord-275730-650sjwyy	199	15	which	which	WDT
cord-275730-650sjwyy	199	16	is	be	VBZ
cord-275730-650sjwyy	199	17	desirable	desirable	JJ
cord-275730-650sjwyy	199	18	in	in	IN
cord-275730-650sjwyy	199	19	developing	develop	VBG
cord-275730-650sjwyy	199	20	countries	country	NNS
cord-275730-650sjwyy	199	21	[	[	-LRB-
cord-275730-650sjwyy	199	22	70	70	CD
cord-275730-650sjwyy	199	23	,	,	,
cord-275730-650sjwyy	199	24	71	71	CD
cord-275730-650sjwyy	199	25	]	]	-RRB-
cord-275730-650sjwyy	199	26	.	.	.
cord-275730-650sjwyy	200	1	However	however	RB
cord-275730-650sjwyy	200	2	,	,	,
cord-275730-650sjwyy	200	3	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	200	4	are	be	VBP
cord-275730-650sjwyy	200	5	often	often	RB
cord-275730-650sjwyy	200	6	related	relate	VBN
cord-275730-650sjwyy	200	7	to	to	IN
cord-275730-650sjwyy	200	8	unwanted	unwanted	JJ
cord-275730-650sjwyy	200	9	cytotoxicities	cytotoxicity	NNS
cord-275730-650sjwyy	200	10	such	such	JJ
cord-275730-650sjwyy	200	11	as	as	IN
cord-275730-650sjwyy	200	12	cell	cell	NN
cord-275730-650sjwyy	200	13	necrosis	necrosis	NN
cord-275730-650sjwyy	200	14	and	and	CC
cord-275730-650sjwyy	200	15	apoptosis	apoptosis	NN
cord-275730-650sjwyy	200	16	[	[	-LRB-
cord-275730-650sjwyy	200	17	72	72	CD
cord-275730-650sjwyy	200	18	]	]	-RRB-
cord-275730-650sjwyy	200	19	that	that	WDT
cord-275730-650sjwyy	200	20	may	may	MD
cord-275730-650sjwyy	200	21	cause	cause	VB
cord-275730-650sjwyy	200	22	safety	safety	NN
cord-275730-650sjwyy	200	23	concerns	concern	NNS
cord-275730-650sjwyy	200	24	in	in	IN
cord-275730-650sjwyy	200	25	prophylactic	prophylactic	JJ
cord-275730-650sjwyy	200	26	vaccines	vaccine	NNS
cord-275730-650sjwyy	200	27	for	for	IN
cord-275730-650sjwyy	200	28	the	the	DT
cord-275730-650sjwyy	200	29	general	general	JJ
cord-275730-650sjwyy	200	30	public	public	NN
cord-275730-650sjwyy	200	31	.	.	.
cord-275730-650sjwyy	201	1	Nevertheless	nevertheless	RB
cord-275730-650sjwyy	201	2	,	,	,
cord-275730-650sjwyy	201	3	for	for	IN
cord-275730-650sjwyy	201	4	cancer	cancer	NN
cord-275730-650sjwyy	201	5	immunotherapy	immunotherapy	NN
cord-275730-650sjwyy	201	6	,	,	,
cord-275730-650sjwyy	201	7	the	the	DT
cord-275730-650sjwyy	201	8	acute	acute	JJ
cord-275730-650sjwyy	201	9	toxicity	toxicity	NN
cord-275730-650sjwyy	201	10	may	may	MD
cord-275730-650sjwyy	201	11	be	be	VB
cord-275730-650sjwyy	201	12	further	further	RB
cord-275730-650sjwyy	201	13	harnessed	harness	VBN
cord-275730-650sjwyy	201	14	for	for	IN
cord-275730-650sjwyy	201	15	tumor	tumor	NN
cord-275730-650sjwyy	201	16	disintegration	disintegration	NN
cord-275730-650sjwyy	201	17	following	follow	VBG
cord-275730-650sjwyy	201	18	local	local	JJ
cord-275730-650sjwyy	201	19	treatment	treatment	NN
cord-275730-650sjwyy	201	20	[	[	-LRB-
cord-275730-650sjwyy	201	21	73	73	CD
cord-275730-650sjwyy	201	22	]	]	-RRB-
cord-275730-650sjwyy	201	23	.	.	.
cord-275730-650sjwyy	202	1	[	[	-LRB-
cord-275730-650sjwyy	202	2	74	74	CD
cord-275730-650sjwyy	202	3	]	]	-RRB-
cord-275730-650sjwyy	202	4	.	.	.
cord-275730-650sjwyy	203	1	However	however	RB
cord-275730-650sjwyy	203	2	,	,	,
cord-275730-650sjwyy	203	3	IRF3	IRF3	NNP
cord-275730-650sjwyy	203	4	-/mice	-/mice	XX
cord-275730-650sjwyy	203	5	responded	respond	VBD
cord-275730-650sjwyy	203	6	to	to	IN
cord-275730-650sjwyy	203	7	CDG	CDG	NNP
cord-275730-650sjwyy	203	8	immunization	immunization	NN
cord-275730-650sjwyy	203	9	[	[	-LRB-
cord-275730-650sjwyy	203	10	74	74	CD
cord-275730-650sjwyy	203	11	]	]	-RRB-
cord-275730-650sjwyy	203	12	.	.	.
cord-275730-650sjwyy	204	1	IRF3	IRF3	NNP
cord-275730-650sjwyy	204	2	mediates	mediate	VBZ
cord-275730-650sjwyy	204	3	STING	sting	NN
cord-275730-650sjwyy	204	4	activated	activate	VBN
cord-275730-650sjwyy	204	5	type	type	NN
cord-275730-650sjwyy	204	6	I	-PRON-	PRP
cord-275730-650sjwyy	204	7	IFNs	ifns	VBP
cord-275730-650sjwyy	204	8	production	production	NN
cord-275730-650sjwyy	204	9	.	.	.
cord-275730-650sjwyy	205	1	The	the	DT
cord-275730-650sjwyy	205	2	results	result	NNS
cord-275730-650sjwyy	205	3	,	,	,
cord-275730-650sjwyy	205	4	thus	thus	RB
cord-275730-650sjwyy	205	5	,	,	,
cord-275730-650sjwyy	205	6	suggested	suggest	VBD
cord-275730-650sjwyy	205	7	that	that	IN
cord-275730-650sjwyy	205	8	the	the	DT
cord-275730-650sjwyy	205	9	in	in	IN
cord-275730-650sjwyy	205	10	vivo	vivo	NNP
cord-275730-650sjwyy	205	11	CDN	CDN	NNP
cord-275730-650sjwyy	205	12	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	205	13	may	may	MD
cord-275730-650sjwyy	205	14	be	be	VB
cord-275730-650sjwyy	205	15	mediated	mediate	VBN
cord-275730-650sjwyy	205	16	by	by	IN
cord-275730-650sjwyy	205	17	a	a	DT
cord-275730-650sjwyy	205	18	STING	sting	NN
cord-275730-650sjwyy	205	19	-	-	HYPH
cord-275730-650sjwyy	205	20	dependent	dependent	JJ
cord-275730-650sjwyy	205	21	,	,	,
cord-275730-650sjwyy	205	22	but	but	CC
cord-275730-650sjwyy	205	23	IRF3-type	irf3-type	NN
cord-275730-650sjwyy	206	1	I	-PRON-	PRP
cord-275730-650sjwyy	206	2	IFNs	ifns	VBP
cord-275730-650sjwyy	206	3	independent	independent	JJ
cord-275730-650sjwyy	206	4	pathway	pathway	NN
cord-275730-650sjwyy	206	5	(	(	-LRB-
cord-275730-650sjwyy	206	6	Figure	figure	NN
cord-275730-650sjwyy	206	7	1	1	CD
cord-275730-650sjwyy	206	8	)	)	-RRB-
cord-275730-650sjwyy	206	9	.	.	.
cord-275730-650sjwyy	207	1	In	in	IN
cord-275730-650sjwyy	207	2	2014	2014	CD
cord-275730-650sjwyy	207	3	,	,	,
cord-275730-650sjwyy	207	4	Blaauboer	Blaauboer	NNP
cord-275730-650sjwyy	207	5	S.	S.	NNP
cord-275730-650sjwyy	207	6	et	et	NNP
cord-275730-650sjwyy	207	7	al	al	NNP
cord-275730-650sjwyy	207	8	.	.	NNP
cord-275730-650sjwyy	207	9	showed	show	VBD
cord-275730-650sjwyy	207	10	that	that	IN
cord-275730-650sjwyy	207	11	CDG	CDG	NNP
cord-275730-650sjwyy	207	12	mucosal	mucosal	JJ
cord-275730-650sjwyy	207	13	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	207	14	depends	depend	VBZ
cord-275730-650sjwyy	207	15	on	on	IN
cord-275730-650sjwyy	207	16	TNFR1	TNFR1	NNP
cord-275730-650sjwyy	207	17	,	,	,
cord-275730-650sjwyy	207	18	but	but	CC
cord-275730-650sjwyy	207	19	not	not	RB
cord-275730-650sjwyy	207	20	type	type	NN
cord-275730-650sjwyy	207	21	I	-PRON-	PRP
cord-275730-650sjwyy	207	22	IFNs	ifns	VBP
cord-275730-650sjwyy	207	23	signaling	signal	VBG
cord-275730-650sjwyy	207	24	[	[	-LRB-
cord-275730-650sjwyy	207	25	52	52	CD
cord-275730-650sjwyy	207	26	]	]	-RRB-
cord-275730-650sjwyy	207	27	.	.	.
cord-275730-650sjwyy	208	1	In	in	IN
cord-275730-650sjwyy	208	2	2019	2019	CD
cord-275730-650sjwyy	208	3	,	,	,
cord-275730-650sjwyy	208	4	Mansour	Mansour	NNP
cord-275730-650sjwyy	208	5	S.	S.	NNP
cord-275730-650sjwyy	208	6	et	et	NNP
cord-275730-650sjwyy	208	7	al	al	NNP
cord-275730-650sjwyy	208	8	.	.	NNP
cord-275730-650sjwyy	208	9	showed	show	VBD
cord-275730-650sjwyy	208	10	that	that	IN
cord-275730-650sjwyy	208	11	TNFR2	tnfr2	NN
cord-275730-650sjwyy	208	12	signaling	signaling	NN
cord-275730-650sjwyy	208	13	is	be	VBZ
cord-275730-650sjwyy	208	14	critical	critical	JJ
cord-275730-650sjwyy	208	15	for	for	IN
cord-275730-650sjwyy	208	16	CDG	CDG	NNP
cord-275730-650sjwyy	208	17	mucosal	mucosal	VBP
cord-275730-650sjwyy	208	18	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	208	19	in	in	IN
cord-275730-650sjwyy	208	20	vivo	vivo	NNP
cord-275730-650sjwyy	208	21	[	[	-LRB-
cord-275730-650sjwyy	208	22	77	77	CD
cord-275730-650sjwyy	208	23	]	]	-RRB-
cord-275730-650sjwyy	208	24	.	.	.
cord-275730-650sjwyy	209	1	TNFR2	TNFR2	NNP
cord-275730-650sjwyy	209	2	is	be	VBZ
cord-275730-650sjwyy	209	3	activated	activate	VBN
cord-275730-650sjwyy	209	4	only	only	RB
cord-275730-650sjwyy	209	5	by	by	IN
cord-275730-650sjwyy	209	6	membrane	membrane	NN
cord-275730-650sjwyy	209	7	TNF	TNF	NNP
cord-275730-650sjwyy	209	8	,	,	,
cord-275730-650sjwyy	209	9	suggesting	suggest	VBG
cord-275730-650sjwyy	209	10	that	that	IN
cord-275730-650sjwyy	209	11	both	both	CC
cord-275730-650sjwyy	209	12	secreted	secrete	VBN
cord-275730-650sjwyy	209	13	and	and	CC
cord-275730-650sjwyy	209	14	membrane	membrane	NN
cord-275730-650sjwyy	209	15	TNF	TNF	NNP
cord-275730-650sjwyy	209	16	are	be	VBP
cord-275730-650sjwyy	209	17	required	require	VBN
cord-275730-650sjwyy	209	18	for	for	IN
cord-275730-650sjwyy	209	19	CDG	CDG	NNP
cord-275730-650sjwyy	209	20	adjuvant	adjuvant	NN
cord-275730-650sjwyy	209	21	responses	response	NNS
cord-275730-650sjwyy	209	22	.	.	.
cord-275730-650sjwyy	210	1	Type	type	NN
cord-275730-650sjwyy	210	2	I	-PRON-	PRP
cord-275730-650sjwyy	210	3	IFNs	ifns	NN
cord-275730-650sjwyy	210	4	induction	induction	NN
cord-275730-650sjwyy	210	5	is	be	VBZ
cord-275730-650sjwyy	210	6	the	the	DT
cord-275730-650sjwyy	210	7	hallmark	hallmark	JJ
cord-275730-650sjwyy	210	8	function	function	NN
cord-275730-650sjwyy	210	9	of	of	IN
cord-275730-650sjwyy	210	10	STING	sting	NN
cord-275730-650sjwyy	210	11	.	.	.
cord-275730-650sjwyy	211	1	Thus	thus	RB
cord-275730-650sjwyy	211	2	,	,	,
cord-275730-650sjwyy	211	3	the	the	DT
cord-275730-650sjwyy	211	4	discovery	discovery	NN
cord-275730-650sjwyy	211	5	that	that	WDT
cord-275730-650sjwyy	211	6	type	type	NN
cord-275730-650sjwyy	211	7	I	-PRON-	PRP
cord-275730-650sjwyy	211	8	IFNs	ifn	NNS
cord-275730-650sjwyy	211	9	are	be	VBP
cord-275730-650sjwyy	211	10	dispensable	dispensable	JJ
cord-275730-650sjwyy	211	11	for	for	IN
cord-275730-650sjwyy	211	12	CDN	CDN	NNP
cord-275730-650sjwyy	211	13	-	-	HYPH
cord-275730-650sjwyy	211	14	induced	induce	VBN
cord-275730-650sjwyy	211	15	antibody	antibody	NN
cord-275730-650sjwyy	211	16	and	and	CC
cord-275730-650sjwyy	211	17	memory	memory	NN
cord-275730-650sjwyy	212	1	Th	th	JJ
cord-275730-650sjwyy	212	2	induction	induction	NN
cord-275730-650sjwyy	212	3	was	be	VBD
cord-275730-650sjwyy	212	4	unexpected	unexpected	JJ
cord-275730-650sjwyy	212	5	.	.	.
cord-275730-650sjwyy	213	1	Nevertheless	nevertheless	RB
cord-275730-650sjwyy	213	2	,	,	,
cord-275730-650sjwyy	213	3	several	several	JJ
cord-275730-650sjwyy	213	4	subsequent	subsequent	JJ
cord-275730-650sjwyy	213	5	studies	study	NNS
cord-275730-650sjwyy	213	6	largely	largely	RB
cord-275730-650sjwyy	213	7	substantiated	substantiate	VBD
cord-275730-650sjwyy	213	8	this	this	DT
cord-275730-650sjwyy	213	9	conclusion	conclusion	NN
cord-275730-650sjwyy	213	10	[	[	-LRB-
cord-275730-650sjwyy	213	11	11	11	CD
cord-275730-650sjwyy	213	12	,	,	,
cord-275730-650sjwyy	213	13	23	23	CD
cord-275730-650sjwyy	213	14	,	,	,
cord-275730-650sjwyy	213	15	30	30	CD
cord-275730-650sjwyy	213	16	,	,	,
cord-275730-650sjwyy	213	17	58	58	CD
cord-275730-650sjwyy	213	18	]	]	-RRB-
cord-275730-650sjwyy	213	19	.	.	.
cord-275730-650sjwyy	214	1	In	in	IN
cord-275730-650sjwyy	214	2	the	the	DT
cord-275730-650sjwyy	214	3	cytoplasm	cytoplasm	NN
cord-275730-650sjwyy	214	4	,	,	,
cord-275730-650sjwyy	214	5	CDNs	cdn	NNS
cord-275730-650sjwyy	214	6	bind	bind	NN
cord-275730-650sjwyy	214	7	to	to	IN
cord-275730-650sjwyy	214	8	STING	sting	NN
cord-275730-650sjwyy	214	9	dimers	dimer	NNS
cord-275730-650sjwyy	214	10	located	locate	VBN
cord-275730-650sjwyy	214	11	on	on	IN
cord-275730-650sjwyy	214	12	the	the	DT
cord-275730-650sjwyy	214	13	endoplasmic	endoplasmic	NN
cord-275730-650sjwyy	214	14	reticulum	reticulum	NN
cord-275730-650sjwyy	214	15	(	(	-LRB-
cord-275730-650sjwyy	214	16	ER	ER	NNP
cord-275730-650sjwyy	214	17	)	)	-RRB-
cord-275730-650sjwyy	214	18	membrane	membrane	NN
cord-275730-650sjwyy	214	19	,	,	,
cord-275730-650sjwyy	214	20	which	which	WDT
cord-275730-650sjwyy	214	21	undergoes	undergo	VBZ
cord-275730-650sjwyy	214	22	conformational	conformational	JJ
cord-275730-650sjwyy	214	23	changes	change	NNS
cord-275730-650sjwyy	214	24	and	and	CC
cord-275730-650sjwyy	214	25	activation	activation	NN
cord-275730-650sjwyy	214	26	.	.	.
cord-275730-650sjwyy	215	1	The	the	DT
cord-275730-650sjwyy	215	2	STING	sting	NN
cord-275730-650sjwyy	215	3	(	(	-LRB-
cord-275730-650sjwyy	215	4	Stimulator	Stimulator	NNP
cord-275730-650sjwyy	215	5	of	of	IN
cord-275730-650sjwyy	215	6	interferon	interferon	NN
cord-275730-650sjwyy	215	7	genes	gene	NNS
cord-275730-650sjwyy	215	8	)	)	-RRB-
cord-275730-650sjwyy	215	9	activation	activation	NN
cord-275730-650sjwyy	215	10	recruits	recruit	NNS
cord-275730-650sjwyy	216	1	kinases	kinase	NNS
cord-275730-650sjwyy	216	2	TANK	tank	NN
cord-275730-650sjwyy	216	3	binding	binding	NN
cord-275730-650sjwyy	216	4	kinase	kinase	NN
cord-275730-650sjwyy	216	5	1	1	CD
cord-275730-650sjwyy	216	6	(	(	-LRB-
cord-275730-650sjwyy	216	7	TBK	TBK	NNP
cord-275730-650sjwyy	216	8	1	1	CD
cord-275730-650sjwyy	216	9	)	)	-RRB-
cord-275730-650sjwyy	216	10	or	or	CC
cord-275730-650sjwyy	216	11	IκB	iκb	NN
cord-275730-650sjwyy	216	12	kinase	kinase	NN
cord-275730-650sjwyy	216	13	(	(	-LRB-
cord-275730-650sjwyy	216	14	Iκκε	Iκκε	NNP
cord-275730-650sjwyy	216	15	)	)	-RRB-
cord-275730-650sjwyy	216	16	.	.	.
cord-275730-650sjwyy	217	1	TBK	TBK	NNP
cord-275730-650sjwyy	217	2	1	1	CD
cord-275730-650sjwyy	217	3	phosphorylates	phosphorylate	VBZ
cord-275730-650sjwyy	217	4	interferon	interferon	NN
cord-275730-650sjwyy	217	5	regulatory	regulatory	JJ
cord-275730-650sjwyy	217	6	factor	factor	NN
cord-275730-650sjwyy	217	7	3	3	CD
cord-275730-650sjwyy	217	8	(	(	-LRB-
cord-275730-650sjwyy	217	9	IRF3	IRF3	NNP
cord-275730-650sjwyy	217	10	)	)	-RRB-
cord-275730-650sjwyy	217	11	,	,	,
cord-275730-650sjwyy	217	12	which	which	WDT
cord-275730-650sjwyy	217	13	dimerizes	dimerizes	NNP
cord-275730-650sjwyy	217	14	and	and	CC
cord-275730-650sjwyy	217	15	translocates	translocates	NNP
cord-275730-650sjwyy	217	16	to	to	IN
cord-275730-650sjwyy	217	17	the	the	DT
cord-275730-650sjwyy	217	18	nucleus	nucleus	NN
cord-275730-650sjwyy	217	19	to	to	TO
cord-275730-650sjwyy	217	20	activate	activate	VB
cord-275730-650sjwyy	217	21	type	type	NN
cord-275730-650sjwyy	217	22	I	-PRON-	PRP
cord-275730-650sjwyy	217	23	IFNs	ifn	NNS
cord-275730-650sjwyy	217	24	.	.	.
cord-275730-650sjwyy	218	1	Iκκε	Iκκε	NNP
cord-275730-650sjwyy	218	2	phosphorylates	phosphorylate	VBZ
cord-275730-650sjwyy	218	3	nuclear	nuclear	JJ
cord-275730-650sjwyy	218	4	factor	factor	NN
cord-275730-650sjwyy	218	5	-	-	:
cord-275730-650sjwyy	218	6	κB	κB	NNP
cord-275730-650sjwyy	219	1	(	(	-LRB-
cord-275730-650sjwyy	219	2	NF	nf	NN
cord-275730-650sjwyy	219	3	-	-	HYPH
cord-275730-650sjwyy	219	4	κB	κB	NNP
cord-275730-650sjwyy	219	5	)	)	-RRB-
cord-275730-650sjwyy	220	1	inhibitor	inhibitor	NN
cord-275730-650sjwyy	220	2	IκBα	IκBα	NNP
cord-275730-650sjwyy	220	3	leading	lead	VBG
cord-275730-650sjwyy	220	4	to	to	IN
cord-275730-650sjwyy	220	5	dissociation	dissociation	NN
cord-275730-650sjwyy	220	6	of	of	IN
cord-275730-650sjwyy	220	7	IκBα	IκBα	NNP
cord-275730-650sjwyy	220	8	from	from	IN
cord-275730-650sjwyy	220	9	NF	NF	NNP
cord-275730-650sjwyy	220	10	-	-	HYPH
cord-275730-650sjwyy	220	11	κB	κb	NN
cord-275730-650sjwyy	220	12	and	and	CC
cord-275730-650sjwyy	220	13	translocation	translocation	NN
cord-275730-650sjwyy	220	14	of	of	IN
cord-275730-650sjwyy	220	15	the	the	DT
cord-275730-650sjwyy	220	16	later	later	JJ
cord-275730-650sjwyy	220	17	to	to	IN
cord-275730-650sjwyy	220	18	the	the	DT
cord-275730-650sjwyy	220	19	nucleus	nucleus	NN
cord-275730-650sjwyy	220	20	to	to	TO
cord-275730-650sjwyy	220	21	activate	activate	VB
cord-275730-650sjwyy	220	22	pro	pro	JJ
cord-275730-650sjwyy	220	23	-	-	JJ
cord-275730-650sjwyy	220	24	inflammatory	inflammatory	JJ
cord-275730-650sjwyy	220	25	cytokines	cytokine	NNS
cord-275730-650sjwyy	220	26	such	such	JJ
cord-275730-650sjwyy	220	27	as	as	IN
cord-275730-650sjwyy	220	28	TNF	TNF	NNP
cord-275730-650sjwyy	220	29	-	-	HYPH
cord-275730-650sjwyy	220	30	α	α	NNP
cord-275730-650sjwyy	220	31	.	.	.
cord-275730-650sjwyy	221	1	McWhirter	McWhirter	NNP
cord-275730-650sjwyy	221	2	S.	S.	NNP
cord-275730-650sjwyy	221	3	M.	M.	NNP
cord-275730-650sjwyy	221	4	et	et	NNP
cord-275730-650sjwyy	221	5	al	al	NNP
cord-275730-650sjwyy	221	6	.	.	NNP
cord-275730-650sjwyy	221	7	demonstrated	demonstrate	VBD
cord-275730-650sjwyy	221	8	that	that	IN
cord-275730-650sjwyy	221	9	i.p	i.p	NNP
cord-275730-650sjwyy	221	10	.	.	.
cord-275730-650sjwyy	221	11	immunization	immunization	NN
cord-275730-650sjwyy	221	12	with	with	IN
cord-275730-650sjwyy	221	13	CDG/(human	CDG/(human	NNP
cord-275730-650sjwyy	221	14	serum	serum	NN
cord-275730-650sjwyy	221	15	albumin	albumin	NN
cord-275730-650sjwyy	221	16	)	)	-RRB-
cord-275730-650sjwyy	222	1	HSA	HSA	NNP
cord-275730-650sjwyy	222	2	failed	fail	VBD
cord-275730-650sjwyy	222	3	to	to	TO
cord-275730-650sjwyy	222	4	generate	generate	VB
cord-275730-650sjwyy	222	5	an	an	DT
cord-275730-650sjwyy	222	6	immune	immune	JJ
cord-275730-650sjwyy	222	7	response	response	NN
cord-275730-650sjwyy	222	8	in	in	IN
cord-275730-650sjwyy	222	9	IFR3	IFR3	NNP
cord-275730-650sjwyy	223	1	-/-/IRF7	-/-/IRF7	.
cord-275730-650sjwyy	224	1	-/-mice	-/-mice	:
cord-275730-650sjwyy	224	2	[	[	-LRB-
cord-275730-650sjwyy	224	3	74	74	CD
cord-275730-650sjwyy	224	4	]	]	-RRB-
cord-275730-650sjwyy	224	5	.	.	.
cord-275730-650sjwyy	225	1	However	however	RB
cord-275730-650sjwyy	225	2	,	,	,
cord-275730-650sjwyy	225	3	IRF3	IRF3	NNP
cord-275730-650sjwyy	225	4	-/-mice	-/-mice	XX
cord-275730-650sjwyy	225	5	responded	respond	VBD
cord-275730-650sjwyy	225	6	to	to	IN
cord-275730-650sjwyy	225	7	CDG	CDG	NNP
cord-275730-650sjwyy	225	8	immunization	immunization	NN
cord-275730-650sjwyy	225	9	[	[	-LRB-
cord-275730-650sjwyy	225	10	74	74	CD
cord-275730-650sjwyy	225	11	]	]	-RRB-
cord-275730-650sjwyy	225	12	.	.	.
cord-275730-650sjwyy	226	1	IRF3	IRF3	NNP
cord-275730-650sjwyy	226	2	mediates	mediate	VBZ
cord-275730-650sjwyy	226	3	STING	sting	NN
cord-275730-650sjwyy	226	4	activated	activate	VBN
cord-275730-650sjwyy	226	5	type	type	NN
cord-275730-650sjwyy	226	6	I	-PRON-	PRP
cord-275730-650sjwyy	226	7	IFNs	ifns	VBP
cord-275730-650sjwyy	226	8	production	production	NN
cord-275730-650sjwyy	226	9	.	.	.
cord-275730-650sjwyy	227	1	The	the	DT
cord-275730-650sjwyy	227	2	results	result	NNS
cord-275730-650sjwyy	227	3	,	,	,
cord-275730-650sjwyy	227	4	thus	thus	RB
cord-275730-650sjwyy	227	5	,	,	,
cord-275730-650sjwyy	227	6	suggested	suggest	VBD
cord-275730-650sjwyy	227	7	that	that	IN
cord-275730-650sjwyy	227	8	the	the	DT
cord-275730-650sjwyy	227	9	in	in	IN
cord-275730-650sjwyy	227	10	vivo	vivo	NNP
cord-275730-650sjwyy	227	11	CDN	CDN	NNP
cord-275730-650sjwyy	227	12	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	227	13	may	may	MD
cord-275730-650sjwyy	227	14	be	be	VB
cord-275730-650sjwyy	227	15	mediated	mediate	VBN
cord-275730-650sjwyy	227	16	by	by	IN
cord-275730-650sjwyy	227	17	a	a	DT
cord-275730-650sjwyy	227	18	STING	sting	NN
cord-275730-650sjwyy	227	19	-	-	HYPH
cord-275730-650sjwyy	227	20	dependent	dependent	JJ
cord-275730-650sjwyy	227	21	,	,	,
cord-275730-650sjwyy	227	22	but	but	CC
cord-275730-650sjwyy	227	23	IRF3-type	irf3-type	NN
cord-275730-650sjwyy	228	1	I	-PRON-	PRP
cord-275730-650sjwyy	228	2	IFNs	ifns	VBP
cord-275730-650sjwyy	228	3	independent	independent	JJ
cord-275730-650sjwyy	228	4	pathway	pathway	NN
cord-275730-650sjwyy	228	5	(	(	-LRB-
cord-275730-650sjwyy	228	6	Figure	figure	NN
cord-275730-650sjwyy	228	7	1	1	CD
cord-275730-650sjwyy	228	8	)	)	-RRB-
cord-275730-650sjwyy	228	9	.	.	.
cord-275730-650sjwyy	229	1	In	in	IN
cord-275730-650sjwyy	229	2	2014	2014	CD
cord-275730-650sjwyy	229	3	,	,	,
cord-275730-650sjwyy	229	4	Blaauboer	Blaauboer	NNP
cord-275730-650sjwyy	229	5	S.	S.	NNP
cord-275730-650sjwyy	229	6	et	et	NNP
cord-275730-650sjwyy	229	7	al	al	NNP
cord-275730-650sjwyy	229	8	.	.	NNP
cord-275730-650sjwyy	229	9	showed	show	VBD
cord-275730-650sjwyy	229	10	that	that	IN
cord-275730-650sjwyy	229	11	CDG	CDG	NNP
cord-275730-650sjwyy	229	12	mucosal	mucosal	JJ
cord-275730-650sjwyy	229	13	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	229	14	depends	depend	VBZ
cord-275730-650sjwyy	229	15	on	on	IN
cord-275730-650sjwyy	229	16	TNFR1	TNFR1	NNP
cord-275730-650sjwyy	229	17	,	,	,
cord-275730-650sjwyy	229	18	but	but	CC
cord-275730-650sjwyy	229	19	not	not	RB
cord-275730-650sjwyy	229	20	type	type	NN
cord-275730-650sjwyy	229	21	I	-PRON-	PRP
cord-275730-650sjwyy	229	22	IFNs	ifns	VBP
cord-275730-650sjwyy	229	23	signaling	signal	VBG
cord-275730-650sjwyy	229	24	[	[	-LRB-
cord-275730-650sjwyy	229	25	52	52	CD
cord-275730-650sjwyy	229	26	]	]	-RRB-
cord-275730-650sjwyy	229	27	.	.	.
cord-275730-650sjwyy	230	1	In	in	IN
cord-275730-650sjwyy	230	2	2019	2019	CD
cord-275730-650sjwyy	230	3	,	,	,
cord-275730-650sjwyy	230	4	Mansour	Mansour	NNP
cord-275730-650sjwyy	230	5	S.	S.	NNP
cord-275730-650sjwyy	230	6	et	et	NNP
cord-275730-650sjwyy	230	7	al	al	NNP
cord-275730-650sjwyy	230	8	.	.	NNP
cord-275730-650sjwyy	230	9	showed	show	VBD
cord-275730-650sjwyy	230	10	that	that	IN
cord-275730-650sjwyy	230	11	TNFR2	tnfr2	NN
cord-275730-650sjwyy	230	12	signaling	signaling	NN
cord-275730-650sjwyy	230	13	is	be	VBZ
cord-275730-650sjwyy	230	14	critical	critical	JJ
cord-275730-650sjwyy	230	15	for	for	IN
cord-275730-650sjwyy	230	16	CDG	CDG	NNP
cord-275730-650sjwyy	230	17	mucosal	mucosal	VBP
cord-275730-650sjwyy	230	18	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	230	19	in	in	IN
cord-275730-650sjwyy	230	20	vivo	vivo	NNP
cord-275730-650sjwyy	230	21	[	[	-LRB-
cord-275730-650sjwyy	230	22	77	77	CD
cord-275730-650sjwyy	230	23	]	]	-RRB-
cord-275730-650sjwyy	230	24	.	.	.
cord-275730-650sjwyy	231	1	TNFR2	TNFR2	NNP
cord-275730-650sjwyy	231	2	is	be	VBZ
cord-275730-650sjwyy	231	3	activated	activate	VBN
cord-275730-650sjwyy	231	4	only	only	RB
cord-275730-650sjwyy	231	5	by	by	IN
cord-275730-650sjwyy	231	6	membrane	membrane	NN
cord-275730-650sjwyy	231	7	TNF	TNF	NNP
cord-275730-650sjwyy	231	8	,	,	,
cord-275730-650sjwyy	231	9	suggesting	suggest	VBG
cord-275730-650sjwyy	231	10	that	that	IN
cord-275730-650sjwyy	231	11	both	both	CC
cord-275730-650sjwyy	231	12	secreted	secrete	VBN
cord-275730-650sjwyy	231	13	and	and	CC
cord-275730-650sjwyy	231	14	membrane	membrane	NN
cord-275730-650sjwyy	231	15	TNF	TNF	NNP
cord-275730-650sjwyy	231	16	are	be	VBP
cord-275730-650sjwyy	231	17	required	require	VBN
cord-275730-650sjwyy	231	18	for	for	IN
cord-275730-650sjwyy	231	19	CDG	CDG	NNP
cord-275730-650sjwyy	231	20	adjuvant	adjuvant	NN
cord-275730-650sjwyy	231	21	responses	response	NNS
cord-275730-650sjwyy	231	22	.	.	.
cord-275730-650sjwyy	232	1	Type	type	NN
cord-275730-650sjwyy	232	2	I	-PRON-	PRP
cord-275730-650sjwyy	232	3	IFNs	ifns	NN
cord-275730-650sjwyy	232	4	induction	induction	NN
cord-275730-650sjwyy	232	5	is	be	VBZ
cord-275730-650sjwyy	232	6	the	the	DT
cord-275730-650sjwyy	232	7	hallmark	hallmark	JJ
cord-275730-650sjwyy	232	8	function	function	NN
cord-275730-650sjwyy	232	9	of	of	IN
cord-275730-650sjwyy	232	10	STING	sting	NN
cord-275730-650sjwyy	232	11	.	.	.
cord-275730-650sjwyy	233	1	Thus	thus	RB
cord-275730-650sjwyy	233	2	,	,	,
cord-275730-650sjwyy	233	3	the	the	DT
cord-275730-650sjwyy	233	4	discovery	discovery	NN
cord-275730-650sjwyy	233	5	that	that	WDT
cord-275730-650sjwyy	233	6	type	type	NN
cord-275730-650sjwyy	233	7	I	-PRON-	PRP
cord-275730-650sjwyy	233	8	IFNs	ifn	NNS
cord-275730-650sjwyy	233	9	are	be	VBP
cord-275730-650sjwyy	233	10	dispensable	dispensable	JJ
cord-275730-650sjwyy	233	11	for	for	IN
cord-275730-650sjwyy	233	12	CDN	CDN	NNP
cord-275730-650sjwyy	233	13	-	-	HYPH
cord-275730-650sjwyy	233	14	induced	induce	VBN
cord-275730-650sjwyy	233	15	antibody	antibody	NN
cord-275730-650sjwyy	233	16	and	and	CC
cord-275730-650sjwyy	233	17	memory	memory	NN
cord-275730-650sjwyy	234	1	Th	th	JJ
cord-275730-650sjwyy	234	2	induction	induction	NN
cord-275730-650sjwyy	234	3	was	be	VBD
cord-275730-650sjwyy	234	4	unexpected	unexpected	JJ
cord-275730-650sjwyy	234	5	.	.	.
cord-275730-650sjwyy	235	1	Nevertheless	nevertheless	RB
cord-275730-650sjwyy	235	2	,	,	,
cord-275730-650sjwyy	235	3	several	several	JJ
cord-275730-650sjwyy	235	4	subsequent	subsequent	JJ
cord-275730-650sjwyy	235	5	studies	study	NNS
cord-275730-650sjwyy	235	6	largely	largely	RB
cord-275730-650sjwyy	235	7	substantiated	substantiate	VBD
cord-275730-650sjwyy	235	8	this	this	DT
cord-275730-650sjwyy	235	9	conclusion	conclusion	NN
cord-275730-650sjwyy	235	10	[	[	-LRB-
cord-275730-650sjwyy	235	11	11	11	CD
cord-275730-650sjwyy	235	12	,	,	,
cord-275730-650sjwyy	235	13	23	23	CD
cord-275730-650sjwyy	235	14	,	,	,
cord-275730-650sjwyy	235	15	30	30	CD
cord-275730-650sjwyy	235	16	,	,	,
cord-275730-650sjwyy	235	17	58	58	CD
cord-275730-650sjwyy	235	18	]	]	-RRB-
cord-275730-650sjwyy	235	19	.	.	.
cord-275730-650sjwyy	236	1	Mechanistically	Mechanistically	NNP
cord-275730-650sjwyy	236	2	,	,	,
cord-275730-650sjwyy	236	3	Blaauboer	Blaauboer	NNP
cord-275730-650sjwyy	236	4	S.	S.	NNP
cord-275730-650sjwyy	236	5	et	et	NNP
cord-275730-650sjwyy	236	6	al	al	NNP
cord-275730-650sjwyy	236	7	.	.	NNP
cord-275730-650sjwyy	236	8	showed	show	VBD
cord-275730-650sjwyy	236	9	that	that	IN
cord-275730-650sjwyy	236	10	CDG	CDG	NNP
cord-275730-650sjwyy	236	11	simultaneously	simultaneously	RB
cord-275730-650sjwyy	236	12	activates	activate	VBZ
cord-275730-650sjwyy	236	13	parallel	parallel	JJ
cord-275730-650sjwyy	236	14	IRF3-type	irf3-type	NN
cord-275730-650sjwyy	237	1	I	-PRON-	PRP
cord-275730-650sjwyy	237	2	IFNs	ifns	VBP
cord-275730-650sjwyy	237	3	and	and	CC
cord-275730-650sjwyy	237	4	RelA	RelA	NNP
cord-275730-650sjwyy	237	5	-	-	HYPH
cord-275730-650sjwyy	237	6	TNF	TNF	NNP
cord-275730-650sjwyy	237	7	signaling	signaling	NN
cord-275730-650sjwyy	237	8	in	in	IN
cord-275730-650sjwyy	237	9	BMDM	BMDM	NNP
cord-275730-650sjwyy	237	10	and	and	CC
cord-275730-650sjwyy	237	11	bone	bone	NN
cord-275730-650sjwyy	237	12	marrow	marrow	NN
cord-275730-650sjwyy	237	13	dendritic	dendritic	JJ
cord-275730-650sjwyy	237	14	cells	cell	NNS
cord-275730-650sjwyy	237	15	(	(	-LRB-
cord-275730-650sjwyy	237	16	BMDCs	bmdc	NNS
cord-275730-650sjwyy	237	17	)	)	-RRB-
cord-275730-650sjwyy	238	1	[	[	-LRB-
cord-275730-650sjwyy	238	2	52	52	CD
cord-275730-650sjwyy	238	3	]	]	-RRB-
cord-275730-650sjwyy	238	4	.	.	.
cord-275730-650sjwyy	239	1	In	in	IN
cord-275730-650sjwyy	239	2	2019	2019	CD
cord-275730-650sjwyy	239	3	,	,	,
cord-275730-650sjwyy	239	4	Mansouri	Mansouri	NNP
cord-275730-650sjwyy	239	5	S.	S.	NNP
cord-275730-650sjwyy	239	6	et	et	NNP
cord-275730-650sjwyy	239	7	al	al	NNP
cord-275730-650sjwyy	239	8	.	.	NNP
cord-275730-650sjwyy	239	9	demonstrated	demonstrate	VBD
cord-275730-650sjwyy	239	10	that	that	IN
cord-275730-650sjwyy	239	11	intranasal	intranasal	NNP
cord-275730-650sjwyy	239	12	administration	administration	NN
cord-275730-650sjwyy	239	13	of	of	IN
cord-275730-650sjwyy	239	14	CDG	CDG	NNP
cord-275730-650sjwyy	239	15	differentially	differentially	RB
cord-275730-650sjwyy	239	16	activates	activate	VBZ
cord-275730-650sjwyy	239	17	RelA	RelA	NNP
cord-275730-650sjwyy	239	18	in	in	IN
cord-275730-650sjwyy	239	19	lung	lung	NN
cord-275730-650sjwyy	239	20	conventional	conventional	JJ
cord-275730-650sjwyy	239	21	dendritic	dendritic	JJ
cord-275730-650sjwyy	239	22	cell	cell	NN
cord-275730-650sjwyy	239	23	1	1	CD
cord-275730-650sjwyy	239	24	(	(	-LRB-
cord-275730-650sjwyy	239	25	cDC1	cdc1	NN
cord-275730-650sjwyy	239	26	)	)	-RRB-
cord-275730-650sjwyy	239	27	,	,	,
cord-275730-650sjwyy	239	28	RelB	relb	NN
cord-275730-650sjwyy	239	29	in	in	IN
cord-275730-650sjwyy	239	30	lung	lung	NN
cord-275730-650sjwyy	239	31	conventional	conventional	JJ
cord-275730-650sjwyy	239	32	dendritic	dendritic	JJ
cord-275730-650sjwyy	239	33	cell	cell	NN
cord-275730-650sjwyy	239	34	2	2	CD
cord-275730-650sjwyy	239	35	(	(	-LRB-
cord-275730-650sjwyy	239	36	cDC2	cDC2	NNP
cord-275730-650sjwyy	239	37	)	)	-RRB-
cord-275730-650sjwyy	239	38	,	,	,
cord-275730-650sjwyy	239	39	and	and	CC
cord-275730-650sjwyy	239	40	both	both	DT
cord-275730-650sjwyy	239	41	RelA	RelA	NNP
cord-275730-650sjwyy	239	42	and	and	CC
cord-275730-650sjwyy	239	43	RelB	relb	NN
cord-275730-650sjwyy	239	44	in	in	IN
cord-275730-650sjwyy	239	45	lung	lung	NN
cord-275730-650sjwyy	239	46	monocyte	monocyte	NNP
cord-275730-650sjwyy	239	47	-	-	HYPH
cord-275730-650sjwyy	239	48	derived	derive	VBN
cord-275730-650sjwyy	239	49	DCs	DCs	NNP
cord-275730-650sjwyy	239	50	(	(	-LRB-
cord-275730-650sjwyy	239	51	moDCs	moDCs	NNP
cord-275730-650sjwyy	239	52	)	)	-RRB-
cord-275730-650sjwyy	240	1	[	[	-LRB-
cord-275730-650sjwyy	240	2	77	77	CD
cord-275730-650sjwyy	240	3	]	]	-RRB-
cord-275730-650sjwyy	240	4	.	.	.
cord-275730-650sjwyy	241	1	RelB	RelB	NNP
cord-275730-650sjwyy	242	1	fl	fl	NNP
cord-275730-650sjwyy	242	2	/	/	SYM
cord-275730-650sjwyy	242	3	fl	fl	NNP
cord-275730-650sjwyy	242	4	CD11c	CD11c	NNP
cord-275730-650sjwyy	242	5	cre	cre	NNP
cord-275730-650sjwyy	242	6	mice	mouse	NNS
cord-275730-650sjwyy	242	7	are	be	VBP
cord-275730-650sjwyy	242	8	deficient	deficient	JJ
cord-275730-650sjwyy	242	9	in	in	IN
cord-275730-650sjwyy	242	10	CDGinduced	cdginduced	JJ
cord-275730-650sjwyy	242	11	memory	memory	NN
cord-275730-650sjwyy	243	1	Th	th	DT
cord-275730-650sjwyy	243	2	responses	response	NNS
cord-275730-650sjwyy	243	3	but	but	CC
cord-275730-650sjwyy	243	4	retained	retain	VBD
cord-275730-650sjwyy	243	5	CDG	CDG	NNP
cord-275730-650sjwyy	243	6	-	-	HYPH
cord-275730-650sjwyy	243	7	induced	induce	VBN
cord-275730-650sjwyy	243	8	antibody	antibody	NN
cord-275730-650sjwyy	243	9	production	production	NN
cord-275730-650sjwyy	243	10	[	[	-LRB-
cord-275730-650sjwyy	243	11	77	77	CD
cord-275730-650sjwyy	243	12	]	]	-RRB-
cord-275730-650sjwyy	243	13	.	.	.
cord-275730-650sjwyy	244	1	The	the	DT
cord-275730-650sjwyy	244	2	RelA	RelA	NNP
cord-275730-650sjwyy	244	3	fl	fl	NNP
cord-275730-650sjwyy	244	4	/	/	SYM
cord-275730-650sjwyy	244	5	fl	fl	NNP
cord-275730-650sjwyy	244	6	CD11C	CD11C	NNP
cord-275730-650sjwyy	244	7	cre	cre	NNP
cord-275730-650sjwyy	244	8	mice	mouse	NNS
cord-275730-650sjwyy	244	9	lost	lose	VBD
cord-275730-650sjwyy	244	10	antibody	antibody	NN
cord-275730-650sjwyy	244	11	and	and	CC
cord-275730-650sjwyy	244	12	memory	memory	NN
cord-275730-650sjwyy	244	13	Th	Th	NNP
cord-275730-650sjwyy	244	14	cell	cell	NN
cord-275730-650sjwyy	244	15	induction	induction	NN
cord-275730-650sjwyy	244	16	in	in	IN
cord-275730-650sjwyy	244	17	lung	lung	NN
cord-275730-650sjwyy	244	18	mucosa	mucosa	RB
cord-275730-650sjwyy	244	19	but	but	CC
cord-275730-650sjwyy	244	20	maintained	maintain	VBD
cord-275730-650sjwyy	244	21	antibody	antibody	NN
cord-275730-650sjwyy	244	22	production	production	NN
cord-275730-650sjwyy	244	23	and	and	CC
cord-275730-650sjwyy	244	24	memory	memory	NN
cord-275730-650sjwyy	245	1	Th	th	JJ
cord-275730-650sjwyy	245	2	induction	induction	NN
cord-275730-650sjwyy	245	3	in	in	IN
cord-275730-650sjwyy	245	4	the	the	DT
cord-275730-650sjwyy	245	5	systemic	systemic	JJ
cord-275730-650sjwyy	245	6	compartment	compartment	NN
cord-275730-650sjwyy	245	7	[	[	-LRB-
cord-275730-650sjwyy	245	8	78	78	CD
cord-275730-650sjwyy	245	9	]	]	-RRB-
cord-275730-650sjwyy	245	10	.	.	.
cord-275730-650sjwyy	246	1	These	these	DT
cord-275730-650sjwyy	246	2	results	result	NNS
cord-275730-650sjwyy	246	3	suggested	suggest	VBD
cord-275730-650sjwyy	246	4	that	that	IN
cord-275730-650sjwyy	246	5	CDNs	cdn	NNS
cord-275730-650sjwyy	246	6	activate	activate	VBP
cord-275730-650sjwyy	246	7	RelA	RelA	NNP
cord-275730-650sjwyy	246	8	and	and	CC
cord-275730-650sjwyy	246	9	RelB	relb	NN
cord-275730-650sjwyy	246	10	in	in	IN
cord-275730-650sjwyy	246	11	vivo	vivo	NN
cord-275730-650sjwyy	246	12	to	to	TO
cord-275730-650sjwyy	246	13	generate	generate	VB
cord-275730-650sjwyy	246	14	TNF	TNF	NNP
cord-275730-650sjwyy	246	15	,	,	,
cord-275730-650sjwyy	246	16	both	both	DT
cord-275730-650sjwyy	246	17	soluble	soluble	JJ
cord-275730-650sjwyy	246	18	TNF	TNF	NNP
cord-275730-650sjwyy	246	19	and	and	CC
cord-275730-650sjwyy	246	20	membrane	membrane	NN
cord-275730-650sjwyy	246	21	TNF	TNF	NNP
cord-275730-650sjwyy	246	22	,	,	,
cord-275730-650sjwyy	246	23	that	that	WDT
cord-275730-650sjwyy	246	24	promote	promote	VBP
cord-275730-650sjwyy	246	25	antibody	antibody	NN
cord-275730-650sjwyy	246	26	production	production	NN
cord-275730-650sjwyy	246	27	and	and	CC
cord-275730-650sjwyy	246	28	memory	memory	NN
cord-275730-650sjwyy	247	1	Th	th	DT
cord-275730-650sjwyy	247	2	cells	cell	NNS
cord-275730-650sjwyy	247	3	induction	induction	NN
cord-275730-650sjwyy	247	4	in	in	IN
cord-275730-650sjwyy	247	5	vivo	vivo	FW
cord-275730-650sjwyy	247	6	(	(	-LRB-
cord-275730-650sjwyy	247	7	Figure	figure	NN
cord-275730-650sjwyy	247	8	1	1	CD
cord-275730-650sjwyy	247	9	)	)	-RRB-
cord-275730-650sjwyy	247	10	.	.	.
cord-275730-650sjwyy	248	1	In	in	IN
cord-275730-650sjwyy	248	2	the	the	DT
cord-275730-650sjwyy	248	3	cytoplasm	cytoplasm	NN
cord-275730-650sjwyy	248	4	,	,	,
cord-275730-650sjwyy	248	5	CDNs	cdn	NNS
cord-275730-650sjwyy	248	6	bind	bind	NN
cord-275730-650sjwyy	248	7	to	to	IN
cord-275730-650sjwyy	248	8	STING	sting	NN
cord-275730-650sjwyy	248	9	dimers	dimer	NNS
cord-275730-650sjwyy	248	10	located	locate	VBN
cord-275730-650sjwyy	248	11	on	on	IN
cord-275730-650sjwyy	248	12	the	the	DT
cord-275730-650sjwyy	248	13	endoplasmic	endoplasmic	NN
cord-275730-650sjwyy	248	14	reticulum	reticulum	NN
cord-275730-650sjwyy	248	15	(	(	-LRB-
cord-275730-650sjwyy	248	16	ER	ER	NNP
cord-275730-650sjwyy	248	17	)	)	-RRB-
cord-275730-650sjwyy	248	18	membrane	membrane	NN
cord-275730-650sjwyy	248	19	,	,	,
cord-275730-650sjwyy	248	20	which	which	WDT
cord-275730-650sjwyy	248	21	undergoes	undergo	VBZ
cord-275730-650sjwyy	248	22	conformational	conformational	JJ
cord-275730-650sjwyy	248	23	changes	change	NNS
cord-275730-650sjwyy	248	24	and	and	CC
cord-275730-650sjwyy	248	25	activation	activation	NN
cord-275730-650sjwyy	248	26	.	.	.
cord-275730-650sjwyy	249	1	The	the	DT
cord-275730-650sjwyy	249	2	STING	sting	NN
cord-275730-650sjwyy	249	3	(	(	-LRB-
cord-275730-650sjwyy	249	4	Stimulator	Stimulator	NNP
cord-275730-650sjwyy	249	5	of	of	IN
cord-275730-650sjwyy	249	6	interferon	interferon	NN
cord-275730-650sjwyy	249	7	genes	gene	NNS
cord-275730-650sjwyy	249	8	)	)	-RRB-
cord-275730-650sjwyy	249	9	activation	activation	NN
cord-275730-650sjwyy	249	10	recruits	recruit	NNS
cord-275730-650sjwyy	250	1	kinases	kinase	NNS
cord-275730-650sjwyy	250	2	TANK	tank	NN
cord-275730-650sjwyy	250	3	binding	binding	NN
cord-275730-650sjwyy	250	4	kinase	kinase	NN
cord-275730-650sjwyy	250	5	1	1	CD
cord-275730-650sjwyy	250	6	(	(	-LRB-
cord-275730-650sjwyy	250	7	TBK	TBK	NNP
cord-275730-650sjwyy	250	8	1	1	CD
cord-275730-650sjwyy	250	9	)	)	-RRB-
cord-275730-650sjwyy	250	10	or	or	CC
cord-275730-650sjwyy	250	11	IκB	iκb	NN
cord-275730-650sjwyy	250	12	kinase	kinase	NN
cord-275730-650sjwyy	250	13	(	(	-LRB-
cord-275730-650sjwyy	250	14	Iκκε	Iκκε	NNP
cord-275730-650sjwyy	250	15	)	)	-RRB-
cord-275730-650sjwyy	250	16	.	.	.
cord-275730-650sjwyy	251	1	TBK	TBK	NNP
cord-275730-650sjwyy	251	2	1	1	CD
cord-275730-650sjwyy	251	3	phosphorylates	phosphorylate	VBZ
cord-275730-650sjwyy	251	4	interferon	interferon	NN
cord-275730-650sjwyy	251	5	regulatory	regulatory	JJ
cord-275730-650sjwyy	251	6	factor	factor	NN
cord-275730-650sjwyy	251	7	3	3	CD
cord-275730-650sjwyy	251	8	(	(	-LRB-
cord-275730-650sjwyy	251	9	IRF3	IRF3	NNP
cord-275730-650sjwyy	251	10	)	)	-RRB-
cord-275730-650sjwyy	251	11	,	,	,
cord-275730-650sjwyy	251	12	which	which	WDT
cord-275730-650sjwyy	251	13	dimerizes	dimerizes	NNP
cord-275730-650sjwyy	251	14	and	and	CC
cord-275730-650sjwyy	251	15	translocates	translocates	NNP
cord-275730-650sjwyy	251	16	to	to	IN
cord-275730-650sjwyy	251	17	the	the	DT
cord-275730-650sjwyy	251	18	nucleus	nucleus	NN
cord-275730-650sjwyy	251	19	to	to	TO
cord-275730-650sjwyy	251	20	activate	activate	VB
cord-275730-650sjwyy	251	21	type	type	NN
cord-275730-650sjwyy	251	22	I	-PRON-	PRP
cord-275730-650sjwyy	251	23	IFNs	ifn	NNS
cord-275730-650sjwyy	251	24	.	.	.
cord-275730-650sjwyy	252	1	Iκκε	Iκκε	NNP
cord-275730-650sjwyy	252	2	phosphorylates	phosphorylate	VBZ
cord-275730-650sjwyy	252	3	nuclear	nuclear	JJ
cord-275730-650sjwyy	252	4	factor	factor	NN
cord-275730-650sjwyy	252	5	-	-	:
cord-275730-650sjwyy	252	6	κB	κB	NNP
cord-275730-650sjwyy	253	1	(	(	-LRB-
cord-275730-650sjwyy	253	2	NF	nf	NN
cord-275730-650sjwyy	253	3	-	-	HYPH
cord-275730-650sjwyy	253	4	κB	κB	NNP
cord-275730-650sjwyy	253	5	)	)	-RRB-
cord-275730-650sjwyy	254	1	inhibitor	inhibitor	NN
cord-275730-650sjwyy	254	2	IκBα	IκBα	NNP
cord-275730-650sjwyy	254	3	leading	lead	VBG
cord-275730-650sjwyy	254	4	to	to	IN
cord-275730-650sjwyy	254	5	dissociation	dissociation	NN
cord-275730-650sjwyy	254	6	of	of	IN
cord-275730-650sjwyy	254	7	IκBα	IκBα	NNP
cord-275730-650sjwyy	254	8	from	from	IN
cord-275730-650sjwyy	254	9	NF	NF	NNP
cord-275730-650sjwyy	254	10	-	-	HYPH
cord-275730-650sjwyy	254	11	κB	κb	NN
cord-275730-650sjwyy	254	12	and	and	CC
cord-275730-650sjwyy	254	13	translocation	translocation	NN
cord-275730-650sjwyy	254	14	of	of	IN
cord-275730-650sjwyy	254	15	the	the	DT
cord-275730-650sjwyy	254	16	later	later	JJ
cord-275730-650sjwyy	254	17	to	to	IN
cord-275730-650sjwyy	254	18	the	the	DT
cord-275730-650sjwyy	254	19	nucleus	nucleus	NN
cord-275730-650sjwyy	254	20	to	to	TO
cord-275730-650sjwyy	254	21	activate	activate	VB
cord-275730-650sjwyy	254	22	pro	pro	JJ
cord-275730-650sjwyy	254	23	-	-	JJ
cord-275730-650sjwyy	254	24	inflammatory	inflammatory	JJ
cord-275730-650sjwyy	254	25	cytokines	cytokine	NNS
cord-275730-650sjwyy	254	26	such	such	JJ
cord-275730-650sjwyy	254	27	as	as	IN
cord-275730-650sjwyy	254	28	TNF	TNF	NNP
cord-275730-650sjwyy	254	29	-	-	HYPH
cord-275730-650sjwyy	254	30	α	α	NNP
cord-275730-650sjwyy	254	31	.	.	.
cord-275730-650sjwyy	255	1	Mechanistically	Mechanistically	NNP
cord-275730-650sjwyy	255	2	,	,	,
cord-275730-650sjwyy	255	3	Blaauboer	Blaauboer	NNP
cord-275730-650sjwyy	255	4	S.	S.	NNP
cord-275730-650sjwyy	255	5	et	et	NNP
cord-275730-650sjwyy	255	6	al	al	NNP
cord-275730-650sjwyy	255	7	.	.	NNP
cord-275730-650sjwyy	255	8	showed	show	VBD
cord-275730-650sjwyy	255	9	that	that	IN
cord-275730-650sjwyy	255	10	CDG	CDG	NNP
cord-275730-650sjwyy	255	11	simultaneously	simultaneously	RB
cord-275730-650sjwyy	255	12	activates	activate	VBZ
cord-275730-650sjwyy	255	13	parallel	parallel	JJ
cord-275730-650sjwyy	255	14	IRF3-type	irf3-type	NN
cord-275730-650sjwyy	256	1	I	-PRON-	PRP
cord-275730-650sjwyy	256	2	IFNs	ifns	VBP
cord-275730-650sjwyy	256	3	and	and	CC
cord-275730-650sjwyy	256	4	RelA	RelA	NNP
cord-275730-650sjwyy	256	5	-	-	HYPH
cord-275730-650sjwyy	256	6	TNF	TNF	NNP
cord-275730-650sjwyy	256	7	signaling	signaling	NN
cord-275730-650sjwyy	256	8	in	in	IN
cord-275730-650sjwyy	256	9	BMDM	BMDM	NNP
cord-275730-650sjwyy	256	10	and	and	CC
cord-275730-650sjwyy	256	11	bone	bone	NN
cord-275730-650sjwyy	256	12	marrow	marrow	NN
cord-275730-650sjwyy	256	13	dendritic	dendritic	JJ
cord-275730-650sjwyy	256	14	cells	cell	NNS
cord-275730-650sjwyy	256	15	(	(	-LRB-
cord-275730-650sjwyy	256	16	BMDCs	bmdc	NNS
cord-275730-650sjwyy	256	17	)	)	-RRB-
cord-275730-650sjwyy	257	1	[	[	-LRB-
cord-275730-650sjwyy	257	2	52	52	CD
cord-275730-650sjwyy	257	3	]	]	-RRB-
cord-275730-650sjwyy	257	4	.	.	.
cord-275730-650sjwyy	258	1	In	in	IN
cord-275730-650sjwyy	258	2	2019	2019	CD
cord-275730-650sjwyy	258	3	,	,	,
cord-275730-650sjwyy	258	4	Mansouri	Mansouri	NNP
cord-275730-650sjwyy	258	5	S.	S.	NNP
cord-275730-650sjwyy	258	6	et	et	NNP
cord-275730-650sjwyy	258	7	al	al	NNP
cord-275730-650sjwyy	258	8	.	.	NNP
cord-275730-650sjwyy	258	9	demonstrated	demonstrate	VBD
cord-275730-650sjwyy	258	10	that	that	IN
cord-275730-650sjwyy	258	11	intranasal	intranasal	NNP
cord-275730-650sjwyy	258	12	administration	administration	NN
cord-275730-650sjwyy	258	13	of	of	IN
cord-275730-650sjwyy	258	14	CDG	CDG	NNP
cord-275730-650sjwyy	258	15	differentially	differentially	RB
cord-275730-650sjwyy	258	16	activates	activate	VBZ
cord-275730-650sjwyy	258	17	RelA	RelA	NNP
cord-275730-650sjwyy	258	18	in	in	IN
cord-275730-650sjwyy	258	19	lung	lung	NN
cord-275730-650sjwyy	258	20	conventional	conventional	JJ
cord-275730-650sjwyy	258	21	dendritic	dendritic	JJ
cord-275730-650sjwyy	258	22	cell	cell	NN
cord-275730-650sjwyy	258	23	1	1	CD
cord-275730-650sjwyy	258	24	(	(	-LRB-
cord-275730-650sjwyy	258	25	cDC1	cdc1	NN
cord-275730-650sjwyy	258	26	)	)	-RRB-
cord-275730-650sjwyy	258	27	,	,	,
cord-275730-650sjwyy	258	28	RelB	relb	NN
cord-275730-650sjwyy	258	29	in	in	IN
cord-275730-650sjwyy	258	30	lung	lung	NN
cord-275730-650sjwyy	258	31	conventional	conventional	JJ
cord-275730-650sjwyy	258	32	dendritic	dendritic	JJ
cord-275730-650sjwyy	258	33	cell	cell	NN
cord-275730-650sjwyy	258	34	2	2	CD
cord-275730-650sjwyy	258	35	(	(	-LRB-
cord-275730-650sjwyy	258	36	cDC2	cDC2	NNP
cord-275730-650sjwyy	258	37	)	)	-RRB-
cord-275730-650sjwyy	258	38	,	,	,
cord-275730-650sjwyy	258	39	and	and	CC
cord-275730-650sjwyy	258	40	both	both	DT
cord-275730-650sjwyy	258	41	RelA	RelA	NNP
cord-275730-650sjwyy	258	42	and	and	CC
cord-275730-650sjwyy	258	43	RelB	relb	NN
cord-275730-650sjwyy	258	44	in	in	IN
cord-275730-650sjwyy	258	45	lung	lung	NN
cord-275730-650sjwyy	258	46	monocyte	monocyte	NNP
cord-275730-650sjwyy	258	47	-	-	HYPH
cord-275730-650sjwyy	258	48	derived	derive	VBN
cord-275730-650sjwyy	258	49	DCs	DCs	NNP
cord-275730-650sjwyy	258	50	(	(	-LRB-
cord-275730-650sjwyy	258	51	moDCs	moDCs	NNP
cord-275730-650sjwyy	258	52	)	)	-RRB-
cord-275730-650sjwyy	259	1	[	[	-LRB-
cord-275730-650sjwyy	259	2	77	77	CD
cord-275730-650sjwyy	259	3	]	]	-RRB-
cord-275730-650sjwyy	259	4	.	.	.
cord-275730-650sjwyy	260	1	RelB	RelB	NNP
cord-275730-650sjwyy	261	1	fl	fl	NNP
cord-275730-650sjwyy	261	2	/	/	SYM
cord-275730-650sjwyy	261	3	fl	fl	NNP
cord-275730-650sjwyy	261	4	CD11c	CD11c	NNP
cord-275730-650sjwyy	261	5	cre	cre	NNP
cord-275730-650sjwyy	261	6	mice	mouse	NNS
cord-275730-650sjwyy	261	7	are	be	VBP
cord-275730-650sjwyy	261	8	deficient	deficient	JJ
cord-275730-650sjwyy	261	9	in	in	IN
cord-275730-650sjwyy	261	10	CDG	CDG	NNP
cord-275730-650sjwyy	261	11	-	-	HYPH
cord-275730-650sjwyy	261	12	induced	induce	VBN
cord-275730-650sjwyy	261	13	memory	memory	NN
cord-275730-650sjwyy	262	1	Th	th	DT
cord-275730-650sjwyy	262	2	responses	response	NNS
cord-275730-650sjwyy	262	3	but	but	CC
cord-275730-650sjwyy	262	4	retained	retain	VBD
cord-275730-650sjwyy	262	5	CDG	CDG	NNP
cord-275730-650sjwyy	262	6	-	-	HYPH
cord-275730-650sjwyy	262	7	induced	induce	VBN
cord-275730-650sjwyy	262	8	antibody	antibody	NN
cord-275730-650sjwyy	262	9	production	production	NN
cord-275730-650sjwyy	262	10	[	[	-LRB-
cord-275730-650sjwyy	262	11	77	77	CD
cord-275730-650sjwyy	262	12	]	]	-RRB-
cord-275730-650sjwyy	262	13	.	.	.
cord-275730-650sjwyy	263	1	The	the	DT
cord-275730-650sjwyy	263	2	RelA	RelA	NNP
cord-275730-650sjwyy	263	3	fl	fl	NNP
cord-275730-650sjwyy	263	4	/	/	SYM
cord-275730-650sjwyy	263	5	fl	fl	NNP
cord-275730-650sjwyy	263	6	CD11C	CD11C	NNP
cord-275730-650sjwyy	263	7	cre	cre	NNP
cord-275730-650sjwyy	263	8	mice	mouse	NNS
cord-275730-650sjwyy	263	9	lost	lose	VBD
cord-275730-650sjwyy	263	10	antibody	antibody	NN
cord-275730-650sjwyy	263	11	and	and	CC
cord-275730-650sjwyy	263	12	memory	memory	NN
cord-275730-650sjwyy	263	13	Th	Th	NNP
cord-275730-650sjwyy	263	14	cell	cell	NN
cord-275730-650sjwyy	263	15	induction	induction	NN
cord-275730-650sjwyy	263	16	in	in	IN
cord-275730-650sjwyy	263	17	lung	lung	NN
cord-275730-650sjwyy	263	18	mucosa	mucosa	RB
cord-275730-650sjwyy	263	19	but	but	CC
cord-275730-650sjwyy	263	20	maintained	maintain	VBD
cord-275730-650sjwyy	263	21	antibody	antibody	NN
cord-275730-650sjwyy	263	22	production	production	NN
cord-275730-650sjwyy	263	23	and	and	CC
cord-275730-650sjwyy	263	24	memory	memory	NN
cord-275730-650sjwyy	264	1	Th	th	JJ
cord-275730-650sjwyy	264	2	induction	induction	NN
cord-275730-650sjwyy	264	3	in	in	IN
cord-275730-650sjwyy	264	4	the	the	DT
cord-275730-650sjwyy	264	5	systemic	systemic	JJ
cord-275730-650sjwyy	264	6	compartment	compartment	NN
cord-275730-650sjwyy	264	7	[	[	-LRB-
cord-275730-650sjwyy	264	8	78	78	CD
cord-275730-650sjwyy	264	9	]	]	-RRB-
cord-275730-650sjwyy	264	10	.	.	.
cord-275730-650sjwyy	265	1	These	these	DT
cord-275730-650sjwyy	265	2	results	result	NNS
cord-275730-650sjwyy	265	3	suggested	suggest	VBD
cord-275730-650sjwyy	265	4	that	that	IN
cord-275730-650sjwyy	265	5	CDNs	cdn	NNS
cord-275730-650sjwyy	265	6	activate	activate	VBP
cord-275730-650sjwyy	265	7	RelA	RelA	NNP
cord-275730-650sjwyy	265	8	and	and	CC
cord-275730-650sjwyy	265	9	RelB	relb	NN
cord-275730-650sjwyy	265	10	in	in	IN
cord-275730-650sjwyy	265	11	vivo	vivo	NN
cord-275730-650sjwyy	265	12	to	to	TO
cord-275730-650sjwyy	265	13	generate	generate	VB
cord-275730-650sjwyy	265	14	TNF	TNF	NNP
cord-275730-650sjwyy	265	15	,	,	,
cord-275730-650sjwyy	265	16	both	both	DT
cord-275730-650sjwyy	265	17	soluble	soluble	JJ
cord-275730-650sjwyy	265	18	TNF	TNF	NNP
cord-275730-650sjwyy	265	19	and	and	CC
cord-275730-650sjwyy	265	20	membrane	membrane	NN
cord-275730-650sjwyy	265	21	TNF	TNF	NNP
cord-275730-650sjwyy	265	22	,	,	,
cord-275730-650sjwyy	265	23	that	that	WDT
cord-275730-650sjwyy	265	24	promote	promote	VBP
cord-275730-650sjwyy	265	25	antibody	antibody	NN
cord-275730-650sjwyy	265	26	production	production	NN
cord-275730-650sjwyy	265	27	and	and	CC
cord-275730-650sjwyy	265	28	memory	memory	NN
cord-275730-650sjwyy	266	1	Th	th	DT
cord-275730-650sjwyy	266	2	cells	cell	NNS
cord-275730-650sjwyy	266	3	induction	induction	NN
cord-275730-650sjwyy	266	4	in	in	IN
cord-275730-650sjwyy	266	5	vivo	vivo	FW
cord-275730-650sjwyy	266	6	(	(	-LRB-
cord-275730-650sjwyy	266	7	Figure	figure	NN
cord-275730-650sjwyy	266	8	1	1	CD
cord-275730-650sjwyy	266	9	)	)	-RRB-
cord-275730-650sjwyy	266	10	.	.	.
cord-275730-650sjwyy	267	1	Though	though	IN
cord-275730-650sjwyy	267	2	type	type	NN
cord-275730-650sjwyy	267	3	I	-PRON-	PRP
cord-275730-650sjwyy	267	4	IFNs	ifn	NNS
cord-275730-650sjwyy	267	5	are	be	VBP
cord-275730-650sjwyy	267	6	dispensable	dispensable	JJ
cord-275730-650sjwyy	267	7	for	for	IN
cord-275730-650sjwyy	267	8	CDN	CDN	NNP
cord-275730-650sjwyy	267	9	-	-	HYPH
cord-275730-650sjwyy	267	10	induced	induce	VBN
cord-275730-650sjwyy	267	11	antibody	antibody	NN
cord-275730-650sjwyy	267	12	production	production	NN
cord-275730-650sjwyy	267	13	,	,	,
cord-275730-650sjwyy	267	14	CDN	CDN	NNP
cord-275730-650sjwyy	267	15	-	-	HYPH
cord-275730-650sjwyy	267	16	induced	induce	VBN
cord-275730-650sjwyy	267	17	anti	anti	JJ
cord-275730-650sjwyy	267	18	-	-	JJ
cord-275730-650sjwyy	267	19	tumor	tumor	JJ
cord-275730-650sjwyy	267	20	immunity	immunity	NN
cord-275730-650sjwyy	267	21	was	be	VBD
cord-275730-650sjwyy	267	22	dependent	dependent	JJ
cord-275730-650sjwyy	267	23	on	on	IN
cord-275730-650sjwyy	267	24	type	type	NN
cord-275730-650sjwyy	268	1	I	-PRON-	PRP
cord-275730-650sjwyy	268	2	IFNs	ifns	VBP
cord-275730-650sjwyy	268	3	produced	produce	VBN
cord-275730-650sjwyy	268	4	in	in	IN
cord-275730-650sjwyy	268	5	the	the	DT
cord-275730-650sjwyy	268	6	tumor	tumor	NN
cord-275730-650sjwyy	268	7	microenvironment	microenvironment	NN
cord-275730-650sjwyy	268	8	[	[	-LRB-
cord-275730-650sjwyy	268	9	27	27	CD
cord-275730-650sjwyy	268	10	,	,	,
cord-275730-650sjwyy	268	11	[	[	-LRB-
cord-275730-650sjwyy	268	12	79	79	CD
cord-275730-650sjwyy	268	13	]	]	-RRB-
cord-275730-650sjwyy	269	1	[	[	-LRB-
cord-275730-650sjwyy	269	2	80	80	CD
cord-275730-650sjwyy	269	3	]	]	-RRB-
cord-275730-650sjwyy	270	1	[	[	-LRB-
cord-275730-650sjwyy	270	2	81	81	CD
cord-275730-650sjwyy	270	3	]	]	-RRB-
cord-275730-650sjwyy	270	4	[	[	-LRB-
cord-275730-650sjwyy	270	5	82	82	CD
cord-275730-650sjwyy	270	6	]	]	-RRB-
cord-275730-650sjwyy	271	1	[	[	-LRB-
cord-275730-650sjwyy	271	2	83	83	CD
cord-275730-650sjwyy	271	3	]	]	-RRB-
cord-275730-650sjwyy	271	4	.	.	.
cord-275730-650sjwyy	272	1	BMDCs	bmdc	NNS
cord-275730-650sjwyy	272	2	from	from	IN
cord-275730-650sjwyy	272	3	WT	WT	NNP
cord-275730-650sjwyy	272	4	and	and	CC
cord-275730-650sjwyy	272	5	IFNAR	IFNAR	NNP
cord-275730-650sjwyy	272	6	-/showed	-/showe	VBD
cord-275730-650sjwyy	273	1	a	a	DT
cord-275730-650sjwyy	273	2	decreased	decreased	JJ
cord-275730-650sjwyy	273	3	cross	cross	NN
cord-275730-650sjwyy	273	4	-	-	NN
cord-275730-650sjwyy	273	5	presentation	presentation	NN
cord-275730-650sjwyy	273	6	of	of	IN
cord-275730-650sjwyy	273	7	the	the	DT
cord-275730-650sjwyy	273	8	SIINFEKL	SIINFEKL	NNP
cord-275730-650sjwyy	273	9	epitope	epitope	NN
cord-275730-650sjwyy	273	10	in	in	IN
cord-275730-650sjwyy	273	11	response	response	NN
cord-275730-650sjwyy	273	12	to	to	IN
cord-275730-650sjwyy	273	13	CDG	CDG	NNP
cord-275730-650sjwyy	273	14	/	/	SYM
cord-275730-650sjwyy	273	15	ovalbumion	ovalbumion	NN
cord-275730-650sjwyy	273	16	(	(	-LRB-
cord-275730-650sjwyy	273	17	OVA	OVA	NNP
cord-275730-650sjwyy	273	18	)	)	-RRB-
cord-275730-650sjwyy	273	19	[	[	-LRB-
cord-275730-650sjwyy	273	20	83	83	CD
cord-275730-650sjwyy	273	21	]	]	-RRB-
cord-275730-650sjwyy	273	22	.	.	.
cord-275730-650sjwyy	274	1	Intranasal	Intranasal	NNP
cord-275730-650sjwyy	274	2	CDA	CDA	NNP
cord-275730-650sjwyy	274	3	immunization	immunization	NN
cord-275730-650sjwyy	274	4	had	have	VBD
cord-275730-650sjwyy	274	5	an	an	DT
cord-275730-650sjwyy	274	6	impaired	impaired	JJ
cord-275730-650sjwyy	274	7	CD8	CD8	NNP
cord-275730-650sjwyy	274	8	+	+	CC
cord-275730-650sjwyy	274	9	T	T	NNP
cord-275730-650sjwyy	274	10	cell	cell	NN
cord-275730-650sjwyy	274	11	function	function	NN
cord-275730-650sjwyy	274	12	in	in	IN
cord-275730-650sjwyy	274	13	IFNAR	IFNAR	NNP
cord-275730-650sjwyy	275	1	-/mice	-/mice	.
cord-275730-650sjwyy	276	1	[	[	-LRB-
cord-275730-650sjwyy	276	2	83	83	CD
cord-275730-650sjwyy	276	3	]	]	-RRB-
cord-275730-650sjwyy	276	4	.	.	.
cord-275730-650sjwyy	277	1	DCs	DCs	NNP
cord-275730-650sjwyy	277	2	bridge	bridge	NNP
cord-275730-650sjwyy	277	3	innate	innate	JJ
cord-275730-650sjwyy	277	4	and	and	CC
cord-275730-650sjwyy	277	5	adaptive	adaptive	JJ
cord-275730-650sjwyy	277	6	immune	immune	JJ
cord-275730-650sjwyy	277	7	responses	response	NNS
cord-275730-650sjwyy	277	8	and	and	CC
cord-275730-650sjwyy	277	9	direct	direct	JJ
cord-275730-650sjwyy	277	10	vaccine	vaccine	NN
cord-275730-650sjwyy	277	11	responses	response	NNS
cord-275730-650sjwyy	277	12	.	.	.
cord-275730-650sjwyy	278	1	In	in	IN
cord-275730-650sjwyy	278	2	2015	2015	CD
cord-275730-650sjwyy	278	3	,	,	,
cord-275730-650sjwyy	278	4	Blaauboer	Blaauboer	NNP
cord-275730-650sjwyy	278	5	S.	S.	NNP
cord-275730-650sjwyy	278	6	et	et	NNP
cord-275730-650sjwyy	278	7	al	al	NNP
cord-275730-650sjwyy	278	8	.	.	NNP
cord-275730-650sjwyy	278	9	showed	show	VBD
cord-275730-650sjwyy	278	10	that	that	IN
cord-275730-650sjwyy	278	11	STING	STING	NNP
cord-275730-650sjwyy	278	12	fl	fl	NNP
cord-275730-650sjwyy	278	13	/	/	SYM
cord-275730-650sjwyy	278	14	fl	fl	NNP
cord-275730-650sjwyy	278	15	CD11C	CD11C	NNP
cord-275730-650sjwyy	278	16	cre	cre	NNP
cord-275730-650sjwyy	278	17	mice	mice	NNP
cord-275730-650sjwyy	278	18	,	,	,
cord-275730-650sjwyy	278	19	which	which	WDT
cord-275730-650sjwyy	278	20	lack	lack	VBP
cord-275730-650sjwyy	278	21	the	the	DT
cord-275730-650sjwyy	278	22	CDN	CDN	NNP
cord-275730-650sjwyy	278	23	receptor	receptor	NN
cord-275730-650sjwyy	278	24	STING	sting	NN
cord-275730-650sjwyy	278	25	in	in	IN
cord-275730-650sjwyy	278	26	CD11C	CD11C	NNP
cord-275730-650sjwyy	278	27	+	+	CC
cord-275730-650sjwyy	278	28	cells	cell	NNS
cord-275730-650sjwyy	278	29	,	,	,
cord-275730-650sjwyy	278	30	including	include	VBG
cord-275730-650sjwyy	278	31	DCs	dc	NNS
cord-275730-650sjwyy	278	32	,	,	,
cord-275730-650sjwyy	278	33	are	be	VBP
cord-275730-650sjwyy	278	34	defective	defective	JJ
cord-275730-650sjwyy	278	35	in	in	IN
cord-275730-650sjwyy	278	36	CDG	CDG	NNP
cord-275730-650sjwyy	278	37	-	-	HYPH
cord-275730-650sjwyy	278	38	induced	induce	VBN
cord-275730-650sjwyy	278	39	humoral	humoral	JJ
cord-275730-650sjwyy	278	40	and	and	CC
cord-275730-650sjwyy	278	41	cellular	cellular	JJ
cord-275730-650sjwyy	278	42	vaccine	vaccine	NN
cord-275730-650sjwyy	278	43	responses	response	NNS
cord-275730-650sjwyy	278	44	[	[	-LRB-
cord-275730-650sjwyy	278	45	43	43	CD
cord-275730-650sjwyy	278	46	]	]	-RRB-
cord-275730-650sjwyy	278	47	.	.	.
cord-275730-650sjwyy	279	1	Thus	thus	RB
cord-275730-650sjwyy	279	2	,	,	,
cord-275730-650sjwyy	279	3	CDNs	cdn	NNS
cord-275730-650sjwyy	279	4	are	be	VBP
cord-275730-650sjwyy	279	5	recognized	recognize	VBN
cord-275730-650sjwyy	279	6	by	by	IN
cord-275730-650sjwyy	279	7	STING	sting	NN
cord-275730-650sjwyy	279	8	in	in	IN
cord-275730-650sjwyy	279	9	DCs	dc	NNS
cord-275730-650sjwyy	279	10	to	to	TO
cord-275730-650sjwyy	279	11	generate	generate	VB
cord-275730-650sjwyy	279	12	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	279	13	responses	response	NNS
cord-275730-650sjwyy	279	14	.	.	.
cord-275730-650sjwyy	280	1	DCs	DCs	NNP
cord-275730-650sjwyy	280	2	are	be	VBP
cord-275730-650sjwyy	280	3	a	a	DT
cord-275730-650sjwyy	280	4	functionally	functionally	RB
cord-275730-650sjwyy	280	5	heterogeneous	heterogeneous	JJ
cord-275730-650sjwyy	280	6	population	population	NN
cord-275730-650sjwyy	280	7	.	.	.
cord-275730-650sjwyy	281	1	Blaauboer	Blaauboer	NNP
cord-275730-650sjwyy	281	2	S.	S.	NNP
cord-275730-650sjwyy	281	3	et	et	NNP
cord-275730-650sjwyy	281	4	al	al	NNP
cord-275730-650sjwyy	281	5	.	.	NNP
cord-275730-650sjwyy	281	6	showed	show	VBD
cord-275730-650sjwyy	281	7	that	that	IN
cord-275730-650sjwyy	281	8	intranasal	intranasal	NNP
cord-275730-650sjwyy	281	9	administration	administration	NN
cord-275730-650sjwyy	281	10	of	of	IN
cord-275730-650sjwyy	281	11	CDG	CDG	NNP
cord-275730-650sjwyy	281	12	activates	activate	VBZ
cord-275730-650sjwyy	281	13	cDC1	cDC1	NNP
cord-275730-650sjwyy	281	14	,	,	,
cord-275730-650sjwyy	281	15	cDC2	cDC2	NNP
cord-275730-650sjwyy	281	16	,	,	,
cord-275730-650sjwyy	281	17	and	and	CC
cord-275730-650sjwyy	282	1	moDCs	moDCs	NNP
cord-275730-650sjwyy	282	2	in	in	IN
cord-275730-650sjwyy	282	3	the	the	DT
cord-275730-650sjwyy	282	4	lung	lung	NN
cord-275730-650sjwyy	282	5	[	[	-LRB-
cord-275730-650sjwyy	282	6	43	43	CD
cord-275730-650sjwyy	282	7	]	]	-RRB-
cord-275730-650sjwyy	282	8	.	.	.
cord-275730-650sjwyy	283	1	Interestingly	interestingly	RB
cord-275730-650sjwyy	283	2	,	,	,
cord-275730-650sjwyy	283	3	Mansouri	Mansouri	NNP
cord-275730-650sjwyy	283	4	S.	S.	NNP
cord-275730-650sjwyy	283	5	et	et	NNP
cord-275730-650sjwyy	283	6	al	al	NNP
cord-275730-650sjwyy	283	7	.	.	NNP
cord-275730-650sjwyy	283	8	showed	show	VBD
cord-275730-650sjwyy	283	9	that	that	IN
cord-275730-650sjwyy	283	10	the	the	DT
cord-275730-650sjwyy	283	11	activation	activation	NN
cord-275730-650sjwyy	283	12	of	of	IN
cord-275730-650sjwyy	283	13	moDCs	moDCs	NNP
cord-275730-650sjwyy	283	14	by	by	IN
cord-275730-650sjwyy	283	15	CDG	CDG	NNP
cord-275730-650sjwyy	283	16	is	be	VBZ
cord-275730-650sjwyy	283	17	indirect	indirect	JJ
cord-275730-650sjwyy	283	18	in	in	IN
cord-275730-650sjwyy	283	19	vivo	vivo	NNP
cord-275730-650sjwyy	283	20	[	[	-LRB-
cord-275730-650sjwyy	283	21	77	77	CD
cord-275730-650sjwyy	283	22	]	]	-RRB-
cord-275730-650sjwyy	283	23	.	.	.
cord-275730-650sjwyy	284	1	For	for	IN
cord-275730-650sjwyy	284	2	the	the	DT
cord-275730-650sjwyy	284	3	reason	reason	NN
cord-275730-650sjwyy	284	4	that	that	WDT
cord-275730-650sjwyy	284	5	is	be	VBZ
cord-275730-650sjwyy	284	6	still	still	RB
cord-275730-650sjwyy	284	7	not	not	RB
cord-275730-650sjwyy	284	8	clear	clear	JJ
cord-275730-650sjwyy	284	9	,	,	,
cord-275730-650sjwyy	284	10	lung	lung	NN
cord-275730-650sjwyy	284	11	moDCs	moDCs	NNP
cord-275730-650sjwyy	284	12	did	do	VBD
cord-275730-650sjwyy	284	13	not	not	RB
cord-275730-650sjwyy	284	14	take	take	VB
cord-275730-650sjwyy	284	15	up	up	RP
cord-275730-650sjwyy	284	16	intranasally	intranasally	RB
cord-275730-650sjwyy	284	17	administered	administer	VBN
cord-275730-650sjwyy	284	18	CDG	CDG	NNP
cord-275730-650sjwyy	284	19	[	[	-LRB-
cord-275730-650sjwyy	284	20	77	77	CD
cord-275730-650sjwyy	284	21	]	]	-RRB-
cord-275730-650sjwyy	284	22	.	.	.
cord-275730-650sjwyy	285	1	Instead	instead	RB
cord-275730-650sjwyy	285	2	,	,	,
cord-275730-650sjwyy	285	3	moDCs	moDCs	NNP
cord-275730-650sjwyy	285	4	are	be	VBP
cord-275730-650sjwyy	285	5	activated	activate	VBN
cord-275730-650sjwyy	285	6	by	by	IN
cord-275730-650sjwyy	285	7	TNF	TNF	NNP
cord-275730-650sjwyy	285	8	from	from	IN
cord-275730-650sjwyy	285	9	CDG	CDG	NNP
cord-275730-650sjwyy	285	10	-	-	HYPH
cord-275730-650sjwyy	285	11	stimulated	stimulate	VBN
cord-275730-650sjwyy	285	12	cDC2	cDC2	NNP
cord-275730-650sjwyy	285	13	[	[	-LRB-
cord-275730-650sjwyy	285	14	77	77	CD
cord-275730-650sjwyy	285	15	]	]	-RRB-
cord-275730-650sjwyy	285	16	.	.	.
cord-275730-650sjwyy	286	1	In	in	IN
cord-275730-650sjwyy	286	2	2019	2019	CD
cord-275730-650sjwyy	286	3	,	,	,
cord-275730-650sjwyy	286	4	Mansouri	Mansouri	NNP
cord-275730-650sjwyy	286	5	S.	S.	NNP
cord-275730-650sjwyy	286	6	et	et	NNP
cord-275730-650sjwyy	286	7	al	al	NNP
cord-275730-650sjwyy	286	8	.	.	NNP
cord-275730-650sjwyy	286	9	demonstrated	demonstrate	VBD
cord-275730-650sjwyy	286	10	that	that	IN
cord-275730-650sjwyy	286	11	CDG	CDG	NNP
cord-275730-650sjwyy	286	12	vaccine	vaccine	NN
cord-275730-650sjwyy	286	13	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	286	14	is	be	VBZ
cord-275730-650sjwyy	286	15	mediated	mediate	VBN
cord-275730-650sjwyy	286	16	by	by	IN
cord-275730-650sjwyy	286	17	cDC2	cDC2	NNP
cord-275730-650sjwyy	286	18	[	[	-LRB-
cord-275730-650sjwyy	286	19	77	77	CD
cord-275730-650sjwyy	286	20	]	]	-RRB-
cord-275730-650sjwyy	286	21	.	.	.
cord-275730-650sjwyy	287	1	cDC1	cdc1	RB
cord-275730-650sjwyy	287	2	,	,	,
cord-275730-650sjwyy	287	3	though	though	RB
cord-275730-650sjwyy	287	4	,	,	,
cord-275730-650sjwyy	287	5	are	be	VBP
cord-275730-650sjwyy	287	6	activated	activate	VBN
cord-275730-650sjwyy	287	7	by	by	IN
cord-275730-650sjwyy	287	8	CDG	CDG	NNP
cord-275730-650sjwyy	287	9	in	in	IN
cord-275730-650sjwyy	287	10	vivo	vivo	NN
cord-275730-650sjwyy	287	11	,	,	,
cord-275730-650sjwyy	287	12	and	and	CC
cord-275730-650sjwyy	287	13	are	be	VBP
cord-275730-650sjwyy	287	14	largely	largely	RB
cord-275730-650sjwyy	287	15	dispensable	dispensable	JJ
cord-275730-650sjwyy	287	16	for	for	IN
cord-275730-650sjwyy	287	17	the	the	DT
cord-275730-650sjwyy	287	18	humoral	humoral	JJ
cord-275730-650sjwyy	287	19	and	and	CC
cord-275730-650sjwyy	287	20	memory	memory	NN
cord-275730-650sjwyy	287	21	Th2	Th2	NNP
cord-275730-650sjwyy	287	22	/	/	SYM
cord-275730-650sjwyy	287	23	Th17	Th17	NNP
cord-275730-650sjwyy	287	24	induction	induction	NN
cord-275730-650sjwyy	287	25	[	[	-LRB-
cord-275730-650sjwyy	287	26	77	77	CD
cord-275730-650sjwyy	287	27	]	]	-RRB-
cord-275730-650sjwyy	287	28	.	.	.
cord-275730-650sjwyy	288	1	moDCs	moDCs	NNP
cord-275730-650sjwyy	288	2	,	,	,
cord-275730-650sjwyy	288	3	on	on	IN
cord-275730-650sjwyy	288	4	the	the	DT
cord-275730-650sjwyy	288	5	other	other	JJ
cord-275730-650sjwyy	288	6	hand	hand	NN
cord-275730-650sjwyy	288	7	,	,	,
cord-275730-650sjwyy	288	8	are	be	VBP
cord-275730-650sjwyy	288	9	critical	critical	JJ
cord-275730-650sjwyy	288	10	for	for	IN
cord-275730-650sjwyy	288	11	generating	generate	VBG
cord-275730-650sjwyy	288	12	lung	lung	NN
cord-275730-650sjwyy	288	13	mucosal	mucosal	JJ
cord-275730-650sjwyy	288	14	IgA	IgA	NNP
cord-275730-650sjwyy	288	15	,	,	,
cord-275730-650sjwyy	288	16	Tfh	Tfh	NNP
cord-275730-650sjwyy	288	17	cells	cell	NNS
cord-275730-650sjwyy	288	18	,	,	,
cord-275730-650sjwyy	288	19	and	and	CC
cord-275730-650sjwyy	288	20	lung	lung	NN
cord-275730-650sjwyy	288	21	memory	memory	NN
cord-275730-650sjwyy	289	1	Th	th	DT
cord-275730-650sjwyy	289	2	cells	cell	NNS
cord-275730-650sjwyy	289	3	[	[	-LRB-
cord-275730-650sjwyy	289	4	77	77	CD
cord-275730-650sjwyy	289	5	,	,	,
cord-275730-650sjwyy	289	6	78	78	CD
cord-275730-650sjwyy	289	7	]	]	-RRB-
cord-275730-650sjwyy	289	8	.	.	.
cord-275730-650sjwyy	290	1	In	in	IN
cord-275730-650sjwyy	290	2	2020	2020	CD
cord-275730-650sjwyy	290	3	,	,	,
cord-275730-650sjwyy	290	4	Mansouri	Mansouri	NNP
cord-275730-650sjwyy	290	5	S.	S.	NNP
cord-275730-650sjwyy	290	6	et	et	NNP
cord-275730-650sjwyy	290	7	al	al	NNP
cord-275730-650sjwyy	290	8	.	.	NNP
cord-275730-650sjwyy	290	9	showed	show	VBD
cord-275730-650sjwyy	290	10	that	that	IN
cord-275730-650sjwyy	290	11	lung	lung	NN
cord-275730-650sjwyy	290	12	moDCs	moDCs	NNP
cord-275730-650sjwyy	290	13	differentiated	differentiate	VBD
cord-275730-650sjwyy	290	14	into	into	IN
cord-275730-650sjwyy	290	15	Bcl6	Bcl6	NNP
cord-275730-650sjwyy	290	16	+	+	CC
cord-275730-650sjwyy	290	17	and	and	CC
cord-275730-650sjwyy	291	1	Bcl6mature	bcl6mature	JJ
cord-275730-650sjwyy	291	2	moDCs	moDCs	NNP
cord-275730-650sjwyy	291	3	by	by	IN
cord-275730-650sjwyy	291	4	secreted	secrete	VBN
cord-275730-650sjwyy	291	5	and	and	CC
cord-275730-650sjwyy	291	6	transmembrane	transmembrane	NNP
cord-275730-650sjwyy	291	7	TNF	TNF	NNP
cord-275730-650sjwyy	291	8	from	from	IN
cord-275730-650sjwyy	291	9	cDC2	cDC2	NNP
cord-275730-650sjwyy	291	10	,	,	,
cord-275730-650sjwyy	291	11	respectively	respectively	RB
cord-275730-650sjwyy	291	12	in	in	IN
cord-275730-650sjwyy	291	13	vivo	vivo	NNP
cord-275730-650sjwyy	291	14	[	[	-LRB-
cord-275730-650sjwyy	291	15	78	78	CD
cord-275730-650sjwyy	291	16	]	]	-RRB-
cord-275730-650sjwyy	291	17	.	.	.
cord-275730-650sjwyy	292	1	The	the	DT
cord-275730-650sjwyy	292	2	Bcl6	Bcl6	NNP
cord-275730-650sjwyy	292	3	+	+	SYM
cord-275730-650sjwyy	292	4	and	and	CC
cord-275730-650sjwyy	292	5	Bcl6mature	bcl6mature	JJ
cord-275730-650sjwyy	292	6	moDCs	moDCs	NNP
cord-275730-650sjwyy	292	7	then	then	RB
cord-275730-650sjwyy	292	8	drive	drive	VB
cord-275730-650sjwyy	292	9	the	the	DT
cord-275730-650sjwyy	292	10	induction	induction	NN
cord-275730-650sjwyy	292	11	of	of	IN
cord-275730-650sjwyy	292	12	lung	lung	NN
cord-275730-650sjwyy	292	13	CD4	CD4	NNP
cord-275730-650sjwyy	292	14	+	+	CC
cord-275730-650sjwyy	292	15	memory	memory	NN
cord-275730-650sjwyy	292	16	T	T	NNP
cord-275730-650sjwyy	292	17	cells	cell	NNS
cord-275730-650sjwyy	292	18	and	and	CC
cord-275730-650sjwyy	292	19	lung	lung	NN
cord-275730-650sjwyy	292	20	Tfh	Tfh	NNP
cord-275730-650sjwyy	292	21	cells	cell	NNS
cord-275730-650sjwyy	292	22	,	,	,
cord-275730-650sjwyy	292	23	respectively	respectively	RB
cord-275730-650sjwyy	292	24	,	,	,
cord-275730-650sjwyy	292	25	to	to	TO
cord-275730-650sjwyy	292	26	promote	promote	VB
cord-275730-650sjwyy	292	27	lung	lung	NN
cord-275730-650sjwyy	292	28	mucosal	mucosal	JJ
cord-275730-650sjwyy	292	29	vaccine	vaccine	NN
cord-275730-650sjwyy	292	30	responses	response	NNS
cord-275730-650sjwyy	292	31	[	[	-LRB-
cord-275730-650sjwyy	292	32	78	78	CD
cord-275730-650sjwyy	292	33	]	]	-RRB-
cord-275730-650sjwyy	292	34	(	(	-LRB-
cord-275730-650sjwyy	292	35	Figure	figure	NN
cord-275730-650sjwyy	292	36	2	2	CD
cord-275730-650sjwyy	292	37	)	)	-RRB-
cord-275730-650sjwyy	292	38	.	.	.
cord-275730-650sjwyy	293	1	BMDCs	bmdc	NNS
cord-275730-650sjwyy	293	2	from	from	IN
cord-275730-650sjwyy	293	3	WT	WT	NNP
cord-275730-650sjwyy	293	4	and	and	CC
cord-275730-650sjwyy	293	5	IFNAR	IFNAR	NNP
cord-275730-650sjwyy	293	6	showed	show	VBD
cord-275730-650sjwyy	293	7	a	a	DT
cord-275730-650sjwyy	293	8	decreased	decreased	JJ
cord-275730-650sjwyy	293	9	cross	cross	NN
cord-275730-650sjwyy	293	10	-	-	NN
cord-275730-650sjwyy	293	11	presentation	presentation	NN
cord-275730-650sjwyy	293	12	of	of	IN
cord-275730-650sjwyy	293	13	the	the	DT
cord-275730-650sjwyy	293	14	SIINFEKL	SIINFEKL	NNP
cord-275730-650sjwyy	293	15	epitope	epitope	NN
cord-275730-650sjwyy	293	16	in	in	IN
cord-275730-650sjwyy	293	17	response	response	NN
cord-275730-650sjwyy	293	18	to	to	IN
cord-275730-650sjwyy	293	19	CDG	CDG	NNP
cord-275730-650sjwyy	293	20	/	/	SYM
cord-275730-650sjwyy	293	21	ovalbumion	ovalbumion	NN
cord-275730-650sjwyy	293	22	(	(	-LRB-
cord-275730-650sjwyy	293	23	OVA	OVA	NNP
cord-275730-650sjwyy	293	24	)	)	-RRB-
cord-275730-650sjwyy	293	25	[	[	-LRB-
cord-275730-650sjwyy	293	26	83	83	CD
cord-275730-650sjwyy	293	27	]	]	-RRB-
cord-275730-650sjwyy	293	28	.	.	.
cord-275730-650sjwyy	294	1	Intranasal	Intranasal	NNP
cord-275730-650sjwyy	294	2	CDA	CDA	NNP
cord-275730-650sjwyy	294	3	immunization	immunization	NN
cord-275730-650sjwyy	294	4	had	have	VBD
cord-275730-650sjwyy	294	5	an	an	DT
cord-275730-650sjwyy	294	6	impaired	impaired	JJ
cord-275730-650sjwyy	294	7	CD8	CD8	NNP
cord-275730-650sjwyy	294	8	+	+	CC
cord-275730-650sjwyy	294	9	T	T	NNP
cord-275730-650sjwyy	294	10	cell	cell	NN
cord-275730-650sjwyy	294	11	function	function	NN
cord-275730-650sjwyy	294	12	in	in	IN
cord-275730-650sjwyy	294	13	IFNAR	IFNAR	NNP
cord-275730-650sjwyy	294	14	-/-mice	-/-mice	.
cord-275730-650sjwyy	295	1	[	[	-LRB-
cord-275730-650sjwyy	295	2	83	83	CD
cord-275730-650sjwyy	295	3	]	]	-RRB-
cord-275730-650sjwyy	295	4	.	.	.
cord-275730-650sjwyy	296	1	DCs	DCs	NNP
cord-275730-650sjwyy	296	2	bridge	bridge	NNP
cord-275730-650sjwyy	296	3	innate	innate	JJ
cord-275730-650sjwyy	296	4	and	and	CC
cord-275730-650sjwyy	296	5	adaptive	adaptive	JJ
cord-275730-650sjwyy	296	6	immune	immune	JJ
cord-275730-650sjwyy	296	7	responses	response	NNS
cord-275730-650sjwyy	296	8	and	and	CC
cord-275730-650sjwyy	296	9	direct	direct	JJ
cord-275730-650sjwyy	296	10	vaccine	vaccine	NN
cord-275730-650sjwyy	296	11	responses	response	NNS
cord-275730-650sjwyy	296	12	.	.	.
cord-275730-650sjwyy	297	1	In	in	IN
cord-275730-650sjwyy	297	2	2015	2015	CD
cord-275730-650sjwyy	297	3	,	,	,
cord-275730-650sjwyy	297	4	Blaauboer	Blaauboer	NNP
cord-275730-650sjwyy	297	5	S.	S.	NNP
cord-275730-650sjwyy	297	6	et	et	NNP
cord-275730-650sjwyy	297	7	al	al	NNP
cord-275730-650sjwyy	297	8	.	.	NNP
cord-275730-650sjwyy	297	9	showed	show	VBD
cord-275730-650sjwyy	297	10	that	that	IN
cord-275730-650sjwyy	297	11	STING	STING	NNP
cord-275730-650sjwyy	297	12	fl	fl	NNP
cord-275730-650sjwyy	297	13	/	/	SYM
cord-275730-650sjwyy	297	14	fl	fl	NNP
cord-275730-650sjwyy	297	15	CD11C	CD11C	NNP
cord-275730-650sjwyy	297	16	cre	cre	NNP
cord-275730-650sjwyy	297	17	mice	mice	NNP
cord-275730-650sjwyy	297	18	,	,	,
cord-275730-650sjwyy	297	19	which	which	WDT
cord-275730-650sjwyy	297	20	lack	lack	VBP
cord-275730-650sjwyy	297	21	the	the	DT
cord-275730-650sjwyy	297	22	CDN	CDN	NNP
cord-275730-650sjwyy	297	23	receptor	receptor	NN
cord-275730-650sjwyy	297	24	STING	sting	NN
cord-275730-650sjwyy	297	25	in	in	IN
cord-275730-650sjwyy	297	26	CD11C	CD11C	NNP
cord-275730-650sjwyy	297	27	+	+	CC
cord-275730-650sjwyy	297	28	cells	cell	NNS
cord-275730-650sjwyy	297	29	,	,	,
cord-275730-650sjwyy	297	30	including	include	VBG
cord-275730-650sjwyy	297	31	DCs	dc	NNS
cord-275730-650sjwyy	297	32	,	,	,
cord-275730-650sjwyy	297	33	are	be	VBP
cord-275730-650sjwyy	297	34	defective	defective	JJ
cord-275730-650sjwyy	297	35	in	in	IN
cord-275730-650sjwyy	297	36	CDG	CDG	NNP
cord-275730-650sjwyy	297	37	-	-	HYPH
cord-275730-650sjwyy	297	38	induced	induce	VBN
cord-275730-650sjwyy	297	39	humoral	humoral	JJ
cord-275730-650sjwyy	297	40	and	and	CC
cord-275730-650sjwyy	297	41	cellular	cellular	JJ
cord-275730-650sjwyy	297	42	vaccine	vaccine	NN
cord-275730-650sjwyy	297	43	responses	response	NNS
cord-275730-650sjwyy	297	44	[	[	-LRB-
cord-275730-650sjwyy	297	45	43	43	CD
cord-275730-650sjwyy	297	46	]	]	-RRB-
cord-275730-650sjwyy	297	47	.	.	.
cord-275730-650sjwyy	298	1	Thus	thus	RB
cord-275730-650sjwyy	298	2	,	,	,
cord-275730-650sjwyy	298	3	CDNs	cdn	NNS
cord-275730-650sjwyy	298	4	are	be	VBP
cord-275730-650sjwyy	298	5	recognized	recognize	VBN
cord-275730-650sjwyy	298	6	by	by	IN
cord-275730-650sjwyy	298	7	STING	sting	NN
cord-275730-650sjwyy	298	8	in	in	IN
cord-275730-650sjwyy	298	9	DCs	dc	NNS
cord-275730-650sjwyy	298	10	to	to	TO
cord-275730-650sjwyy	298	11	generate	generate	VB
cord-275730-650sjwyy	298	12	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	298	13	responses	response	NNS
cord-275730-650sjwyy	298	14	.	.	.
cord-275730-650sjwyy	299	1	DCs	DCs	NNP
cord-275730-650sjwyy	299	2	are	be	VBP
cord-275730-650sjwyy	299	3	a	a	DT
cord-275730-650sjwyy	299	4	functionally	functionally	RB
cord-275730-650sjwyy	299	5	heterogeneous	heterogeneous	JJ
cord-275730-650sjwyy	299	6	population	population	NN
cord-275730-650sjwyy	299	7	.	.	.
cord-275730-650sjwyy	300	1	Blaauboer	Blaauboer	NNP
cord-275730-650sjwyy	300	2	S.	S.	NNP
cord-275730-650sjwyy	300	3	et	et	NNP
cord-275730-650sjwyy	300	4	al	al	NNP
cord-275730-650sjwyy	300	5	.	.	NNP
cord-275730-650sjwyy	300	6	showed	show	VBD
cord-275730-650sjwyy	300	7	that	that	IN
cord-275730-650sjwyy	300	8	intranasal	intranasal	NNP
cord-275730-650sjwyy	300	9	administration	administration	NN
cord-275730-650sjwyy	300	10	of	of	IN
cord-275730-650sjwyy	300	11	CDG	CDG	NNP
cord-275730-650sjwyy	300	12	activates	activate	VBZ
cord-275730-650sjwyy	300	13	cDC1	cDC1	NNP
cord-275730-650sjwyy	300	14	,	,	,
cord-275730-650sjwyy	300	15	cDC2	cDC2	NNP
cord-275730-650sjwyy	300	16	,	,	,
cord-275730-650sjwyy	300	17	and	and	CC
cord-275730-650sjwyy	301	1	moDCs	moDCs	NNP
cord-275730-650sjwyy	301	2	in	in	IN
cord-275730-650sjwyy	301	3	the	the	DT
cord-275730-650sjwyy	301	4	lung	lung	NN
cord-275730-650sjwyy	301	5	[	[	-LRB-
cord-275730-650sjwyy	301	6	43	43	CD
cord-275730-650sjwyy	301	7	]	]	-RRB-
cord-275730-650sjwyy	301	8	.	.	.
cord-275730-650sjwyy	302	1	Interestingly	interestingly	RB
cord-275730-650sjwyy	302	2	,	,	,
cord-275730-650sjwyy	302	3	Mansouri	Mansouri	NNP
cord-275730-650sjwyy	302	4	S.	S.	NNP
cord-275730-650sjwyy	302	5	et	et	NNP
cord-275730-650sjwyy	302	6	al	al	NNP
cord-275730-650sjwyy	302	7	.	.	NNP
cord-275730-650sjwyy	302	8	showed	show	VBD
cord-275730-650sjwyy	302	9	that	that	IN
cord-275730-650sjwyy	302	10	the	the	DT
cord-275730-650sjwyy	302	11	activation	activation	NN
cord-275730-650sjwyy	302	12	of	of	IN
cord-275730-650sjwyy	302	13	moDCs	moDCs	NNP
cord-275730-650sjwyy	302	14	by	by	IN
cord-275730-650sjwyy	302	15	CDG	CDG	NNP
cord-275730-650sjwyy	302	16	is	be	VBZ
cord-275730-650sjwyy	302	17	indirect	indirect	JJ
cord-275730-650sjwyy	302	18	in	in	IN
cord-275730-650sjwyy	302	19	vivo	vivo	NNP
cord-275730-650sjwyy	302	20	[	[	-LRB-
cord-275730-650sjwyy	302	21	77	77	CD
cord-275730-650sjwyy	302	22	]	]	-RRB-
cord-275730-650sjwyy	302	23	.	.	.
cord-275730-650sjwyy	303	1	For	for	IN
cord-275730-650sjwyy	303	2	the	the	DT
cord-275730-650sjwyy	303	3	reason	reason	NN
cord-275730-650sjwyy	303	4	that	that	WDT
cord-275730-650sjwyy	303	5	is	be	VBZ
cord-275730-650sjwyy	303	6	still	still	RB
cord-275730-650sjwyy	303	7	not	not	RB
cord-275730-650sjwyy	303	8	clear	clear	JJ
cord-275730-650sjwyy	303	9	,	,	,
cord-275730-650sjwyy	303	10	lung	lung	NN
cord-275730-650sjwyy	303	11	moDCs	moDCs	NNP
cord-275730-650sjwyy	303	12	did	do	VBD
cord-275730-650sjwyy	303	13	not	not	RB
cord-275730-650sjwyy	303	14	take	take	VB
cord-275730-650sjwyy	303	15	up	up	RP
cord-275730-650sjwyy	303	16	intranasally	intranasally	RB
cord-275730-650sjwyy	303	17	administered	administer	VBN
cord-275730-650sjwyy	303	18	CDG	CDG	NNP
cord-275730-650sjwyy	303	19	[	[	-LRB-
cord-275730-650sjwyy	303	20	77	77	CD
cord-275730-650sjwyy	303	21	]	]	-RRB-
cord-275730-650sjwyy	303	22	.	.	.
cord-275730-650sjwyy	304	1	Instead	instead	RB
cord-275730-650sjwyy	304	2	,	,	,
cord-275730-650sjwyy	304	3	moDCs	moDCs	NNP
cord-275730-650sjwyy	304	4	are	be	VBP
cord-275730-650sjwyy	304	5	activated	activate	VBN
cord-275730-650sjwyy	304	6	by	by	IN
cord-275730-650sjwyy	304	7	TNF	TNF	NNP
cord-275730-650sjwyy	304	8	from	from	IN
cord-275730-650sjwyy	304	9	CDG	CDG	NNP
cord-275730-650sjwyy	304	10	-	-	HYPH
cord-275730-650sjwyy	304	11	stimulated	stimulate	VBN
cord-275730-650sjwyy	304	12	cDC2	cDC2	NNP
cord-275730-650sjwyy	304	13	[	[	-LRB-
cord-275730-650sjwyy	304	14	77	77	CD
cord-275730-650sjwyy	304	15	]	]	-RRB-
cord-275730-650sjwyy	304	16	.	.	.
cord-275730-650sjwyy	305	1	In	in	IN
cord-275730-650sjwyy	305	2	2019	2019	CD
cord-275730-650sjwyy	305	3	,	,	,
cord-275730-650sjwyy	305	4	Mansouri	Mansouri	NNP
cord-275730-650sjwyy	305	5	S.	S.	NNP
cord-275730-650sjwyy	305	6	et	et	NNP
cord-275730-650sjwyy	305	7	al	al	NNP
cord-275730-650sjwyy	305	8	.	.	NNP
cord-275730-650sjwyy	305	9	demonstrated	demonstrate	VBD
cord-275730-650sjwyy	305	10	that	that	IN
cord-275730-650sjwyy	305	11	CDG	CDG	NNP
cord-275730-650sjwyy	305	12	vaccine	vaccine	NN
cord-275730-650sjwyy	305	13	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	305	14	is	be	VBZ
cord-275730-650sjwyy	305	15	mediated	mediate	VBN
cord-275730-650sjwyy	305	16	by	by	IN
cord-275730-650sjwyy	305	17	cDC2	cDC2	NNP
cord-275730-650sjwyy	305	18	[	[	-LRB-
cord-275730-650sjwyy	305	19	77	77	CD
cord-275730-650sjwyy	305	20	]	]	-RRB-
cord-275730-650sjwyy	305	21	.	.	.
cord-275730-650sjwyy	306	1	cDC1	cdc1	RB
cord-275730-650sjwyy	306	2	,	,	,
cord-275730-650sjwyy	306	3	though	though	RB
cord-275730-650sjwyy	306	4	,	,	,
cord-275730-650sjwyy	306	5	are	be	VBP
cord-275730-650sjwyy	306	6	activated	activate	VBN
cord-275730-650sjwyy	306	7	by	by	IN
cord-275730-650sjwyy	306	8	CDG	CDG	NNP
cord-275730-650sjwyy	306	9	in	in	IN
cord-275730-650sjwyy	306	10	vivo	vivo	NN
cord-275730-650sjwyy	306	11	,	,	,
cord-275730-650sjwyy	306	12	and	and	CC
cord-275730-650sjwyy	306	13	are	be	VBP
cord-275730-650sjwyy	306	14	largely	largely	RB
cord-275730-650sjwyy	306	15	dispensable	dispensable	JJ
cord-275730-650sjwyy	306	16	for	for	IN
cord-275730-650sjwyy	306	17	the	the	DT
cord-275730-650sjwyy	306	18	humoral	humoral	JJ
cord-275730-650sjwyy	306	19	and	and	CC
cord-275730-650sjwyy	306	20	memory	memory	NN
cord-275730-650sjwyy	306	21	Th2	Th2	NNP
cord-275730-650sjwyy	306	22	/	/	SYM
cord-275730-650sjwyy	306	23	Th17	Th17	NNP
cord-275730-650sjwyy	306	24	induction	induction	NN
cord-275730-650sjwyy	306	25	[	[	-LRB-
cord-275730-650sjwyy	306	26	77	77	CD
cord-275730-650sjwyy	306	27	]	]	-RRB-
cord-275730-650sjwyy	306	28	.	.	.
cord-275730-650sjwyy	307	1	moDCs	moDCs	NNP
cord-275730-650sjwyy	307	2	,	,	,
cord-275730-650sjwyy	307	3	on	on	IN
cord-275730-650sjwyy	307	4	the	the	DT
cord-275730-650sjwyy	307	5	other	other	JJ
cord-275730-650sjwyy	307	6	hand	hand	NN
cord-275730-650sjwyy	307	7	,	,	,
cord-275730-650sjwyy	307	8	are	be	VBP
cord-275730-650sjwyy	307	9	critical	critical	JJ
cord-275730-650sjwyy	307	10	for	for	IN
cord-275730-650sjwyy	307	11	generating	generate	VBG
cord-275730-650sjwyy	307	12	lung	lung	NN
cord-275730-650sjwyy	307	13	mucosal	mucosal	JJ
cord-275730-650sjwyy	307	14	IgA	IgA	NNP
cord-275730-650sjwyy	307	15	,	,	,
cord-275730-650sjwyy	307	16	Tfh	Tfh	NNP
cord-275730-650sjwyy	307	17	cells	cell	NNS
cord-275730-650sjwyy	307	18	,	,	,
cord-275730-650sjwyy	307	19	and	and	CC
cord-275730-650sjwyy	307	20	lung	lung	NN
cord-275730-650sjwyy	307	21	memory	memory	NN
cord-275730-650sjwyy	308	1	Th	th	DT
cord-275730-650sjwyy	308	2	cells	cell	NNS
cord-275730-650sjwyy	308	3	[	[	-LRB-
cord-275730-650sjwyy	308	4	77	77	CD
cord-275730-650sjwyy	308	5	,	,	,
cord-275730-650sjwyy	308	6	78	78	CD
cord-275730-650sjwyy	308	7	]	]	-RRB-
cord-275730-650sjwyy	308	8	.	.	.
cord-275730-650sjwyy	309	1	In	in	IN
cord-275730-650sjwyy	309	2	2020	2020	CD
cord-275730-650sjwyy	309	3	,	,	,
cord-275730-650sjwyy	309	4	Mansouri	Mansouri	NNP
cord-275730-650sjwyy	309	5	S.	S.	NNP
cord-275730-650sjwyy	309	6	et	et	NNP
cord-275730-650sjwyy	309	7	al	al	NNP
cord-275730-650sjwyy	309	8	.	.	NNP
cord-275730-650sjwyy	309	9	showed	show	VBD
cord-275730-650sjwyy	309	10	that	that	IN
cord-275730-650sjwyy	309	11	lung	lung	NN
cord-275730-650sjwyy	309	12	moDCs	moDCs	NNP
cord-275730-650sjwyy	309	13	differentiated	differentiate	VBD
cord-275730-650sjwyy	309	14	into	into	IN
cord-275730-650sjwyy	309	15	Bcl6	Bcl6	NNP
cord-275730-650sjwyy	309	16	+	+	CC
cord-275730-650sjwyy	309	17	and	and	CC
cord-275730-650sjwyy	309	18	Bcl6	Bcl6	NNP
cord-275730-650sjwyy	309	19	-mature	-mature	NN
cord-275730-650sjwyy	309	20	moDCs	moDCs	NNP
cord-275730-650sjwyy	309	21	by	by	IN
cord-275730-650sjwyy	309	22	secreted	secrete	VBN
cord-275730-650sjwyy	309	23	and	and	CC
cord-275730-650sjwyy	309	24	transmembrane	transmembrane	NNP
cord-275730-650sjwyy	309	25	TNF	TNF	NNP
cord-275730-650sjwyy	309	26	from	from	IN
cord-275730-650sjwyy	309	27	cDC2	cDC2	NNP
cord-275730-650sjwyy	309	28	,	,	,
cord-275730-650sjwyy	309	29	respectively	respectively	RB
cord-275730-650sjwyy	309	30	in	in	IN
cord-275730-650sjwyy	309	31	vivo	vivo	NNP
cord-275730-650sjwyy	309	32	[	[	-LRB-
cord-275730-650sjwyy	309	33	78	78	CD
cord-275730-650sjwyy	309	34	]	]	-RRB-
cord-275730-650sjwyy	309	35	.	.	.
cord-275730-650sjwyy	310	1	The	the	DT
cord-275730-650sjwyy	310	2	Bcl6	Bcl6	NNP
cord-275730-650sjwyy	310	3	+	+	SYM
cord-275730-650sjwyy	310	4	and	and	CC
cord-275730-650sjwyy	310	5	Bcl6-mature	Bcl6-mature	.
cord-275730-650sjwyy	311	1	moDCs	moDCs	NNP
cord-275730-650sjwyy	311	2	then	then	RB
cord-275730-650sjwyy	311	3	drive	drive	VB
cord-275730-650sjwyy	311	4	the	the	DT
cord-275730-650sjwyy	311	5	induction	induction	NN
cord-275730-650sjwyy	311	6	of	of	IN
cord-275730-650sjwyy	311	7	lung	lung	NN
cord-275730-650sjwyy	311	8	CD4	CD4	NNP
cord-275730-650sjwyy	311	9	+	+	CC
cord-275730-650sjwyy	311	10	memory	memory	NN
cord-275730-650sjwyy	311	11	T	T	NNP
cord-275730-650sjwyy	311	12	cells	cell	NNS
cord-275730-650sjwyy	311	13	and	and	CC
cord-275730-650sjwyy	311	14	lung	lung	NN
cord-275730-650sjwyy	311	15	Tfh	Tfh	NNP
cord-275730-650sjwyy	311	16	cells	cell	NNS
cord-275730-650sjwyy	311	17	,	,	,
cord-275730-650sjwyy	311	18	respectively	respectively	RB
cord-275730-650sjwyy	311	19	,	,	,
cord-275730-650sjwyy	311	20	to	to	TO
cord-275730-650sjwyy	311	21	promote	promote	VB
cord-275730-650sjwyy	311	22	lung	lung	NN
cord-275730-650sjwyy	311	23	mucosal	mucosal	JJ
cord-275730-650sjwyy	311	24	vaccine	vaccine	NN
cord-275730-650sjwyy	311	25	responses	response	NNS
cord-275730-650sjwyy	311	26	[	[	-LRB-
cord-275730-650sjwyy	311	27	78	78	CD
cord-275730-650sjwyy	311	28	]	]	-RRB-
cord-275730-650sjwyy	311	29	(	(	-LRB-
cord-275730-650sjwyy	311	30	Figure	figure	NN
cord-275730-650sjwyy	311	31	2	2	CD
cord-275730-650sjwyy	311	32	)	)	-RRB-
cord-275730-650sjwyy	311	33	.	.	.
cord-275730-650sjwyy	312	1	Cellular	cellular	JJ
cord-275730-650sjwyy	312	2	mechanism	mechanism	NN
cord-275730-650sjwyy	312	3	of	of	IN
cord-275730-650sjwyy	312	4	CDN	CDN	NNP
cord-275730-650sjwyy	312	5	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	312	6	by	by	IN
cord-275730-650sjwyy	312	7	lung	lung	NN
cord-275730-650sjwyy	312	8	DCs	DCs	NNP
cord-275730-650sjwyy	312	9	.	.	.
cord-275730-650sjwyy	313	1	Intranasal	intranasal	NN
cord-275730-650sjwyy	313	2	immunization	immunization	NN
cord-275730-650sjwyy	313	3	of	of	IN
cord-275730-650sjwyy	313	4	CDN	CDN	NNP
cord-275730-650sjwyy	313	5	promotes	promote	VBZ
cord-275730-650sjwyy	313	6	its	-PRON-	PRP$
cord-275730-650sjwyy	313	7	uptake	uptake	NN
cord-275730-650sjwyy	313	8	by	by	IN
cord-275730-650sjwyy	313	9	functionally	functionally	RB
cord-275730-650sjwyy	313	10	distinct	distinct	JJ
cord-275730-650sjwyy	313	11	lung	lung	NN
cord-275730-650sjwyy	313	12	DC	DC	NNP
cord-275730-650sjwyy	313	13	subsets	subset	NNS
cord-275730-650sjwyy	313	14	:	:	:
cord-275730-650sjwyy	313	15	cDC1	cdc1	NN
cord-275730-650sjwyy	313	16	,	,	,
cord-275730-650sjwyy	313	17	TNFR2	tnfr2	NN
cord-275730-650sjwyy	313	18	+	+	CC
cord-275730-650sjwyy	313	19	cDC2	cDC2	NNP
cord-275730-650sjwyy	313	20	,	,	,
cord-275730-650sjwyy	313	21	and	and	CC
cord-275730-650sjwyy	313	22	TNFR2	TNFR2	NNP
cord-275730-650sjwyy	313	23	-cDC2	-cdc2	NN
cord-275730-650sjwyy	313	24	.	.	.
cord-275730-650sjwyy	314	1	Upon	upon	IN
cord-275730-650sjwyy	314	2	the	the	DT
cord-275730-650sjwyy	314	3	CDN	CDN	NNP
cord-275730-650sjwyy	314	4	uptake	uptake	NN
cord-275730-650sjwyy	314	5	,	,	,
cord-275730-650sjwyy	314	6	cDC1	cDC1	NNP
cord-275730-650sjwyy	314	7	and	and	CC
cord-275730-650sjwyy	314	8	TNFR2	TNFR2	NNP
cord-275730-650sjwyy	314	9	+	+	CC
cord-275730-650sjwyy	314	10	cDC2	cDC2	NNP
cord-275730-650sjwyy	314	11	mature	mature	VB
cord-275730-650sjwyy	314	12	and	and	CC
cord-275730-650sjwyy	314	13	migrate	migrate	VBP
cord-275730-650sjwyy	314	14	towards	towards	IN
cord-275730-650sjwyy	314	15	the	the	DT
cord-275730-650sjwyy	314	16	lung	lung	NN
cord-275730-650sjwyy	314	17	draining	drain	VBG
cord-275730-650sjwyy	314	18	lymph	lymph	NN
cord-275730-650sjwyy	314	19	node	node	NN
cord-275730-650sjwyy	314	20	where	where	WRB
cord-275730-650sjwyy	314	21	they	-PRON-	PRP
cord-275730-650sjwyy	314	22	direct	direct	VBP
cord-275730-650sjwyy	314	23	naïve	naïve	JJ
cord-275730-650sjwyy	314	24	T	t	NN
cord-275730-650sjwyy	314	25	cells	cell	NNS
cord-275730-650sjwyy	314	26	towards	towards	IN
cord-275730-650sjwyy	314	27	Th1	th1	NN
cord-275730-650sjwyy	314	28	,	,	,
cord-275730-650sjwyy	314	29	Th2	Th2	NNP
cord-275730-650sjwyy	314	30	,	,	,
cord-275730-650sjwyy	314	31	and	and	CC
cord-275730-650sjwyy	314	32	Th17	Th17	NNP
cord-275730-650sjwyy	315	1	effector	effector	NNP
cord-275730-650sjwyy	315	2	cells	cell	NNS
cord-275730-650sjwyy	315	3	.	.	.
cord-275730-650sjwyy	316	1	The	the	DT
cord-275730-650sjwyy	316	2	TNFR2	tnfr2	NN
cord-275730-650sjwyy	316	3	-cDC2	-cdc2	NN
cord-275730-650sjwyy	316	4	population	population	NN
cord-275730-650sjwyy	316	5	,	,	,
cord-275730-650sjwyy	316	6	on	on	IN
cord-275730-650sjwyy	316	7	the	the	DT
cord-275730-650sjwyy	316	8	CDN	CDN	NNP
cord-275730-650sjwyy	316	9	uptake	uptake	NN
cord-275730-650sjwyy	316	10	,	,	,
cord-275730-650sjwyy	316	11	is	be	VBZ
cord-275730-650sjwyy	316	12	activated	activate	VBN
cord-275730-650sjwyy	316	13	but	but	CC
cord-275730-650sjwyy	316	14	does	do	VBZ
cord-275730-650sjwyy	316	15	not	not	RB
cord-275730-650sjwyy	316	16	migrate	migrate	VB
cord-275730-650sjwyy	316	17	.	.	.
cord-275730-650sjwyy	317	1	Instead	instead	RB
cord-275730-650sjwyy	317	2	,	,	,
cord-275730-650sjwyy	317	3	the	the	DT
cord-275730-650sjwyy	317	4	TNFR2	tnfr2	NN
cord-275730-650sjwyy	317	5	-cDC2	-cdc2	NN
cord-275730-650sjwyy	317	6	produces	produce	VBZ
cord-275730-650sjwyy	317	7	transmembrane	transmembrane	NNP
cord-275730-650sjwyy	317	8	TNF	TNF	NNP
cord-275730-650sjwyy	317	9	,	,	,
cord-275730-650sjwyy	317	10	which	which	WDT
cord-275730-650sjwyy	317	11	engages	engage	VBZ
cord-275730-650sjwyy	317	12	TNFR2	tnfr2	NN
cord-275730-650sjwyy	317	13	on	on	IN
cord-275730-650sjwyy	317	14	monocyte	monocyte	NNP
cord-275730-650sjwyy	317	15	-	-	HYPH
cord-275730-650sjwyy	317	16	derived	derive	VBN
cord-275730-650sjwyy	317	17	DCs	DCs	NNP
cord-275730-650sjwyy	317	18	(	(	-LRB-
cord-275730-650sjwyy	317	19	moDCs	moDCs	NNP
cord-275730-650sjwyy	317	20	)	)	-RRB-
cord-275730-650sjwyy	317	21	to	to	TO
cord-275730-650sjwyy	317	22	trigger	trigger	VB
cord-275730-650sjwyy	317	23	lung	lung	NN
cord-275730-650sjwyy	317	24	moDCs	moDCs	NNP
cord-275730-650sjwyy	317	25	activation	activation	NN
cord-275730-650sjwyy	317	26	.	.	.
cord-275730-650sjwyy	318	1	Activated	activate	VBN
cord-275730-650sjwyy	318	2	lung	lung	NN
cord-275730-650sjwyy	318	3	moDCs	modcs	CD
cord-275730-650sjwyy	318	4	induce	induce	VB
cord-275730-650sjwyy	318	5	Tfh	Tfh	NNP
cord-275730-650sjwyy	318	6	,	,	,
cord-275730-650sjwyy	318	7	GC	GC	NNP
cord-275730-650sjwyy	318	8	formation	formation	NN
cord-275730-650sjwyy	318	9	,	,	,
cord-275730-650sjwyy	318	10	and	and	CC
cord-275730-650sjwyy	318	11	IgA	IgA	NNP
cord-275730-650sjwyy	318	12	production	production	NN
cord-275730-650sjwyy	318	13	in	in	IN
cord-275730-650sjwyy	318	14	the	the	DT
cord-275730-650sjwyy	318	15	lung	lung	NN
cord-275730-650sjwyy	318	16	.	.	.
cord-275730-650sjwyy	319	1	Figure	figure	NN
cord-275730-650sjwyy	319	2	2	2	CD
cord-275730-650sjwyy	319	3	.	.	.
cord-275730-650sjwyy	320	1	Cellular	cellular	JJ
cord-275730-650sjwyy	320	2	mechanism	mechanism	NN
cord-275730-650sjwyy	320	3	of	of	IN
cord-275730-650sjwyy	320	4	CDN	CDN	NNP
cord-275730-650sjwyy	320	5	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	320	6	by	by	IN
cord-275730-650sjwyy	320	7	lung	lung	NN
cord-275730-650sjwyy	320	8	DCs	DCs	NNP
cord-275730-650sjwyy	320	9	.	.	.
cord-275730-650sjwyy	321	1	Intranasal	intranasal	NN
cord-275730-650sjwyy	321	2	immunization	immunization	NN
cord-275730-650sjwyy	321	3	of	of	IN
cord-275730-650sjwyy	321	4	CDN	CDN	NNP
cord-275730-650sjwyy	321	5	promotes	promote	VBZ
cord-275730-650sjwyy	321	6	its	-PRON-	PRP$
cord-275730-650sjwyy	321	7	uptake	uptake	NN
cord-275730-650sjwyy	321	8	by	by	IN
cord-275730-650sjwyy	321	9	functionally	functionally	RB
cord-275730-650sjwyy	321	10	distinct	distinct	JJ
cord-275730-650sjwyy	321	11	lung	lung	NN
cord-275730-650sjwyy	321	12	DC	DC	NNP
cord-275730-650sjwyy	321	13	subsets	subset	NNS
cord-275730-650sjwyy	321	14	:	:	:
cord-275730-650sjwyy	321	15	cDC1	cdc1	NN
cord-275730-650sjwyy	321	16	,	,	,
cord-275730-650sjwyy	321	17	TNFR2	tnfr2	NN
cord-275730-650sjwyy	321	18	+	+	CC
cord-275730-650sjwyy	321	19	cDC2	cDC2	NNP
cord-275730-650sjwyy	321	20	,	,	,
cord-275730-650sjwyy	321	21	and	and	CC
cord-275730-650sjwyy	321	22	TNFR2	TNFR2	NNP
cord-275730-650sjwyy	321	23	-cDC2	-cdc2	NN
cord-275730-650sjwyy	321	24	.	.	.
cord-275730-650sjwyy	322	1	Upon	upon	IN
cord-275730-650sjwyy	322	2	the	the	DT
cord-275730-650sjwyy	322	3	CDN	CDN	NNP
cord-275730-650sjwyy	322	4	uptake	uptake	NN
cord-275730-650sjwyy	322	5	,	,	,
cord-275730-650sjwyy	322	6	cDC1	cDC1	NNP
cord-275730-650sjwyy	322	7	and	and	CC
cord-275730-650sjwyy	322	8	TNFR2	TNFR2	NNP
cord-275730-650sjwyy	322	9	+	+	CC
cord-275730-650sjwyy	322	10	cDC2	cDC2	NNP
cord-275730-650sjwyy	322	11	mature	mature	VB
cord-275730-650sjwyy	322	12	and	and	CC
cord-275730-650sjwyy	322	13	migrate	migrate	VBP
cord-275730-650sjwyy	322	14	towards	towards	IN
cord-275730-650sjwyy	322	15	the	the	DT
cord-275730-650sjwyy	322	16	lung	lung	NN
cord-275730-650sjwyy	322	17	draining	drain	VBG
cord-275730-650sjwyy	322	18	lymph	lymph	NN
cord-275730-650sjwyy	322	19	node	node	NN
cord-275730-650sjwyy	322	20	where	where	WRB
cord-275730-650sjwyy	322	21	they	-PRON-	PRP
cord-275730-650sjwyy	322	22	direct	direct	VBP
cord-275730-650sjwyy	322	23	naïve	naïve	JJ
cord-275730-650sjwyy	322	24	T	t	NN
cord-275730-650sjwyy	322	25	cells	cell	NNS
cord-275730-650sjwyy	322	26	towards	towards	IN
cord-275730-650sjwyy	322	27	Th1	th1	NN
cord-275730-650sjwyy	322	28	,	,	,
cord-275730-650sjwyy	322	29	Th2	Th2	NNP
cord-275730-650sjwyy	322	30	,	,	,
cord-275730-650sjwyy	322	31	and	and	CC
cord-275730-650sjwyy	322	32	Th17	Th17	NNP
cord-275730-650sjwyy	323	1	effector	effector	NNP
cord-275730-650sjwyy	323	2	cells	cell	NNS
cord-275730-650sjwyy	323	3	.	.	.
cord-275730-650sjwyy	324	1	The	the	DT
cord-275730-650sjwyy	324	2	TNFR2	tnfr2	NN
cord-275730-650sjwyy	324	3	-cDC2	-cdc2	NN
cord-275730-650sjwyy	324	4	population	population	NN
cord-275730-650sjwyy	324	5	,	,	,
cord-275730-650sjwyy	324	6	on	on	IN
cord-275730-650sjwyy	324	7	the	the	DT
cord-275730-650sjwyy	324	8	CDN	CDN	NNP
cord-275730-650sjwyy	324	9	uptake	uptake	NN
cord-275730-650sjwyy	324	10	,	,	,
cord-275730-650sjwyy	324	11	is	be	VBZ
cord-275730-650sjwyy	324	12	activated	activate	VBN
cord-275730-650sjwyy	324	13	but	but	CC
cord-275730-650sjwyy	324	14	does	do	VBZ
cord-275730-650sjwyy	324	15	not	not	RB
cord-275730-650sjwyy	324	16	migrate	migrate	VB
cord-275730-650sjwyy	324	17	.	.	.
cord-275730-650sjwyy	325	1	Instead	instead	RB
cord-275730-650sjwyy	325	2	,	,	,
cord-275730-650sjwyy	325	3	the	the	DT
cord-275730-650sjwyy	325	4	TNFR2	tnfr2	NN
cord-275730-650sjwyy	325	5	-cDC2	-cdc2	NN
cord-275730-650sjwyy	325	6	produces	produce	VBZ
cord-275730-650sjwyy	325	7	transmembrane	transmembrane	NNP
cord-275730-650sjwyy	325	8	TNF	TNF	NNP
cord-275730-650sjwyy	325	9	,	,	,
cord-275730-650sjwyy	325	10	which	which	WDT
cord-275730-650sjwyy	325	11	engages	engage	VBZ
cord-275730-650sjwyy	325	12	TNFR2	tnfr2	NN
cord-275730-650sjwyy	325	13	on	on	IN
cord-275730-650sjwyy	325	14	monocyte	monocyte	NNP
cord-275730-650sjwyy	325	15	-	-	HYPH
cord-275730-650sjwyy	325	16	derived	derive	VBN
cord-275730-650sjwyy	325	17	DCs	DCs	NNP
cord-275730-650sjwyy	325	18	(	(	-LRB-
cord-275730-650sjwyy	325	19	moDCs	moDCs	NNP
cord-275730-650sjwyy	325	20	)	)	-RRB-
cord-275730-650sjwyy	325	21	to	to	TO
cord-275730-650sjwyy	325	22	trigger	trigger	VB
cord-275730-650sjwyy	325	23	lung	lung	NN
cord-275730-650sjwyy	325	24	moDCs	moDCs	NNP
cord-275730-650sjwyy	325	25	activation	activation	NN
cord-275730-650sjwyy	325	26	.	.	.
cord-275730-650sjwyy	326	1	Activated	activate	VBN
cord-275730-650sjwyy	326	2	lung	lung	NN
cord-275730-650sjwyy	326	3	moDCs	modcs	CD
cord-275730-650sjwyy	326	4	induce	induce	VB
cord-275730-650sjwyy	326	5	Tfh	Tfh	NNP
cord-275730-650sjwyy	326	6	,	,	,
cord-275730-650sjwyy	326	7	GC	GC	NNP
cord-275730-650sjwyy	326	8	formation	formation	NN
cord-275730-650sjwyy	326	9	,	,	,
cord-275730-650sjwyy	326	10	and	and	CC
cord-275730-650sjwyy	326	11	IgA	IgA	NNP
cord-275730-650sjwyy	326	12	production	production	NN
cord-275730-650sjwyy	326	13	in	in	IN
cord-275730-650sjwyy	326	14	the	the	DT
cord-275730-650sjwyy	326	15	lung	lung	NN
cord-275730-650sjwyy	326	16	.	.	.
cord-275730-650sjwyy	327	1	The	the	DT
cord-275730-650sjwyy	327	2	in	in	IN
cord-275730-650sjwyy	327	3	vivo	vivo	NN
cord-275730-650sjwyy	327	4	cellular	cellular	JJ
cord-275730-650sjwyy	327	5	mechanism	mechanism	NN
cord-275730-650sjwyy	327	6	of	of	IN
cord-275730-650sjwyy	327	7	CDNs	CDNs	NNP
cord-275730-650sjwyy	327	8	may	may	MD
cord-275730-650sjwyy	327	9	differ	differ	VB
cord-275730-650sjwyy	327	10	depending	depend	VBG
cord-275730-650sjwyy	327	11	on	on	IN
cord-275730-650sjwyy	327	12	their	-PRON-	PRP$
cord-275730-650sjwyy	327	13	delivery	delivery	NN
cord-275730-650sjwyy	327	14	methods	method	NNS
cord-275730-650sjwyy	327	15	and	and	CC
cord-275730-650sjwyy	327	16	composition	composition	NN
cord-275730-650sjwyy	327	17	during	during	IN
cord-275730-650sjwyy	327	18	immunization	immunization	NN
cord-275730-650sjwyy	327	19	.	.	.
cord-275730-650sjwyy	328	1	However	however	RB
cord-275730-650sjwyy	328	2	,	,	,
cord-275730-650sjwyy	328	3	activating	activate	VBG
cord-275730-650sjwyy	328	4	DCs	DCs	NNP
cord-275730-650sjwyy	328	5	is	be	VBZ
cord-275730-650sjwyy	328	6	likely	likely	RB
cord-275730-650sjwyy	328	7	a	a	DT
cord-275730-650sjwyy	328	8	common	common	JJ
cord-275730-650sjwyy	328	9	mechanism	mechanism	NN
cord-275730-650sjwyy	328	10	for	for	IN
cord-275730-650sjwyy	328	11	CDNs	cdn	NNS
cord-275730-650sjwyy	328	12	to	to	TO
cord-275730-650sjwyy	328	13	induce	induce	VB
cord-275730-650sjwyy	328	14	vaccine	vaccine	NN
cord-275730-650sjwyy	328	15	responses	response	NNS
cord-275730-650sjwyy	328	16	.	.	.
cord-275730-650sjwyy	329	1	For	for	IN
cord-275730-650sjwyy	329	2	example	example	NN
cord-275730-650sjwyy	329	3	,	,	,
cord-275730-650sjwyy	329	4	to	to	TO
cord-275730-650sjwyy	329	5	enhance	enhance	VB
cord-275730-650sjwyy	329	6	memory	memory	NN
cord-275730-650sjwyy	330	1	Th	th	DT
cord-275730-650sjwyy	330	2	responses	response	NNS
cord-275730-650sjwyy	330	3	,	,	,
cord-275730-650sjwyy	330	4	the	the	DT
cord-275730-650sjwyy	330	5	CDN	CDN	NNP
cord-275730-650sjwyy	330	6	composition	composition	NN
cord-275730-650sjwyy	330	7	needs	need	VBZ
cord-275730-650sjwyy	330	8	to	to	TO
cord-275730-650sjwyy	330	9	activate	activate	VB
cord-275730-650sjwyy	330	10	cDC2	cDC2	NNP
cord-275730-650sjwyy	330	11	.	.	.
cord-275730-650sjwyy	331	1	To	to	TO
cord-275730-650sjwyy	331	2	enhance	enhance	VB
cord-275730-650sjwyy	331	3	lung	lung	NN
cord-275730-650sjwyy	331	4	mucosal	mucosal	NNP
cord-275730-650sjwyy	331	5	IgA	IgA	NNP
cord-275730-650sjwyy	331	6	and	and	CC
cord-275730-650sjwyy	331	7	lung	lung	NN
cord-275730-650sjwyy	331	8	memory	memory	NN
cord-275730-650sjwyy	332	1	Th	th	DT
cord-275730-650sjwyy	332	2	responses	response	NNS
cord-275730-650sjwyy	332	3	,	,	,
cord-275730-650sjwyy	332	4	moDCs	moDCs	NNP
cord-275730-650sjwyy	332	5	activation	activation	NN
cord-275730-650sjwyy	332	6	is	be	VBZ
cord-275730-650sjwyy	332	7	a	a	DT
cord-275730-650sjwyy	332	8	must	must	NN
cord-275730-650sjwyy	332	9	.	.	.
cord-275730-650sjwyy	333	1	Lastly	lastly	RB
cord-275730-650sjwyy	333	2	,	,	,
cord-275730-650sjwyy	333	3	to	to	TO
cord-275730-650sjwyy	333	4	generate	generate	VB
cord-275730-650sjwyy	333	5	cytotoxic	cytotoxic	JJ
cord-275730-650sjwyy	333	6	CD8	CD8	NNP
cord-275730-650sjwyy	333	7	+	+	CC
cord-275730-650sjwyy	333	8	T	T	NNP
cord-275730-650sjwyy	333	9	cells	cell	NNS
cord-275730-650sjwyy	333	10	responses	response	NNS
cord-275730-650sjwyy	333	11	,	,	,
cord-275730-650sjwyy	333	12	the	the	DT
cord-275730-650sjwyy	333	13	CDN	CDN	NNP
cord-275730-650sjwyy	333	14	composition	composition	NN
cord-275730-650sjwyy	333	15	needs	need	VBZ
cord-275730-650sjwyy	333	16	to	to	TO
cord-275730-650sjwyy	333	17	activate	activate	VB
cord-275730-650sjwyy	333	18	cDC1	cDC1	NNP
cord-275730-650sjwyy	333	19	that	that	WDT
cord-275730-650sjwyy	333	20	specializes	specialize	VBZ
cord-275730-650sjwyy	333	21	in	in	IN
cord-275730-650sjwyy	333	22	antigen	antigen	NN
cord-275730-650sjwyy	333	23	cross	cross	JJ
cord-275730-650sjwyy	333	24	-	-	NN
cord-275730-650sjwyy	333	25	presentation	presentation	NN
cord-275730-650sjwyy	333	26	.	.	.
cord-275730-650sjwyy	334	1	The	the	DT
cord-275730-650sjwyy	334	2	anti	anti	JJ
cord-275730-650sjwyy	334	3	-	-	JJ
cord-275730-650sjwyy	334	4	tumor	tumor	JJ
cord-275730-650sjwyy	334	5	activity	activity	NN
cord-275730-650sjwyy	334	6	of	of	IN
cord-275730-650sjwyy	334	7	STING	sting	NN
cord-275730-650sjwyy	334	8	depends	depend	VBZ
cord-275730-650sjwyy	334	9	on	on	IN
cord-275730-650sjwyy	334	10	type	type	NN
cord-275730-650sjwyy	334	11	I	-PRON-	PRP
cord-275730-650sjwyy	334	12	IFNs	ifns	VBP
cord-275730-650sjwyy	334	13	production	production	NN
cord-275730-650sjwyy	334	14	.	.	.
cord-275730-650sjwyy	335	1	However	however	RB
cord-275730-650sjwyy	335	2	,	,	,
cord-275730-650sjwyy	335	3	the	the	DT
cord-275730-650sjwyy	335	4	cellular	cellular	JJ
cord-275730-650sjwyy	335	5	source	source	NN
cord-275730-650sjwyy	335	6	of	of	IN
cord-275730-650sjwyy	335	7	type	type	NN
cord-275730-650sjwyy	335	8	I	-PRON-	PRP
cord-275730-650sjwyy	335	9	IFNs	ifns	VBP
cord-275730-650sjwyy	335	10	remains	remain	VBZ
cord-275730-650sjwyy	335	11	debatable	debatable	JJ
cord-275730-650sjwyy	335	12	.	.	.
cord-275730-650sjwyy	336	1	Tumor	tumor	NN
cord-275730-650sjwyy	336	2	-	-	HYPH
cord-275730-650sjwyy	336	3	infiltrating	infiltrate	VBG
cord-275730-650sjwyy	336	4	dendritic	dendritic	JJ
cord-275730-650sjwyy	336	5	cells	cell	NNS
cord-275730-650sjwyy	336	6	(	(	-LRB-
cord-275730-650sjwyy	336	7	DCs	DCs	NNP
cord-275730-650sjwyy	336	8	)	)	-RRB-
cord-275730-650sjwyy	336	9	were	be	VBD
cord-275730-650sjwyy	336	10	identified	identify	VBN
cord-275730-650sjwyy	336	11	as	as	IN
cord-275730-650sjwyy	336	12	the	the	DT
cord-275730-650sjwyy	336	13	major	major	JJ
cord-275730-650sjwyy	336	14	cellular	cellular	JJ
cord-275730-650sjwyy	336	15	source	source	NN
cord-275730-650sjwyy	336	16	of	of	IN
cord-275730-650sjwyy	336	17	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	336	18	at	at	IN
cord-275730-650sjwyy	336	19	the	the	DT
cord-275730-650sjwyy	336	20	tumor	tumor	NN
cord-275730-650sjwyy	336	21	site	site	NN
cord-275730-650sjwyy	336	22	[	[	-LRB-
cord-275730-650sjwyy	336	23	84	84	CD
cord-275730-650sjwyy	336	24	]	]	-RRB-
cord-275730-650sjwyy	336	25	.	.	.
cord-275730-650sjwyy	337	1	In	in	IN
cord-275730-650sjwyy	337	2	addition	addition	NN
cord-275730-650sjwyy	337	3	to	to	IN
cord-275730-650sjwyy	337	4	DCs	DCs	NNP
cord-275730-650sjwyy	337	5	,	,	,
cord-275730-650sjwyy	337	6	tumor	tumor	NN
cord-275730-650sjwyy	337	7	cells	cell	NNS
cord-275730-650sjwyy	337	8	themselves	-PRON-	PRP
cord-275730-650sjwyy	337	9	are	be	VBP
cord-275730-650sjwyy	337	10	induced	induce	VBN
cord-275730-650sjwyy	337	11	to	to	TO
cord-275730-650sjwyy	337	12	contribute	contribute	VB
cord-275730-650sjwyy	337	13	to	to	IN
cord-275730-650sjwyy	337	14	the	the	DT
cord-275730-650sjwyy	337	15	production	production	NN
cord-275730-650sjwyy	337	16	of	of	IN
cord-275730-650sjwyy	337	17	IFN	IFN	NNP
cord-275730-650sjwyy	337	18	-	-	HYPH
cord-275730-650sjwyy	337	19	β	β	NNP
cord-275730-650sjwyy	337	20	[	[	-LRB-
cord-275730-650sjwyy	337	21	84	84	CD
cord-275730-650sjwyy	337	22	]	]	-RRB-
cord-275730-650sjwyy	337	23	.	.	.
cord-275730-650sjwyy	338	1	Similarly	similarly	RB
cord-275730-650sjwyy	338	2	,	,	,
cord-275730-650sjwyy	338	3	STING	STING	NNP
cord-275730-650sjwyy	338	4	was	be	VBD
cord-275730-650sjwyy	338	5	essential	essential	JJ
cord-275730-650sjwyy	338	6	for	for	IN
cord-275730-650sjwyy	338	7	radiation	radiation	NN
cord-275730-650sjwyy	338	8	-	-	HYPH
cord-275730-650sjwyy	338	9	induced	induce	VBN
cord-275730-650sjwyy	338	10	adaptive	adaptive	JJ
cord-275730-650sjwyy	338	11	immune	immune	JJ
cord-275730-650sjwyy	338	12	responses	response	NNS
cord-275730-650sjwyy	338	13	,	,	,
cord-275730-650sjwyy	338	14	which	which	WDT
cord-275730-650sjwyy	338	15	relied	rely	VBD
cord-275730-650sjwyy	338	16	on	on	IN
cord-275730-650sjwyy	338	17	type	type	NN
cord-275730-650sjwyy	338	18	I	-PRON-	PRP
cord-275730-650sjwyy	338	19	IFN	IFN	NNP
cord-275730-650sjwyy	338	20	signaling	signal	VBG
cord-275730-650sjwyy	338	21	on	on	IN
cord-275730-650sjwyy	338	22	DCs	dc	NNS
cord-275730-650sjwyy	338	23	[	[	-LRB-
cord-275730-650sjwyy	338	24	80	80	CD
cord-275730-650sjwyy	338	25	]	]	-RRB-
cord-275730-650sjwyy	338	26	.	.	.
cord-275730-650sjwyy	339	1	Other	other	JJ
cord-275730-650sjwyy	339	2	studies	study	NNS
cord-275730-650sjwyy	339	3	identified	identify	VBD
cord-275730-650sjwyy	339	4	endothelial	endothelial	JJ
cord-275730-650sjwyy	339	5	cells	cell	NNS
cord-275730-650sjwyy	339	6	as	as	IN
cord-275730-650sjwyy	339	7	the	the	DT
cord-275730-650sjwyy	339	8	type	type	NN
cord-275730-650sjwyy	339	9	I	-PRON-	PRP
cord-275730-650sjwyy	339	10	IFNs	ifns	VBP
cord-275730-650sjwyy	339	11	producer	producer	NN
cord-275730-650sjwyy	339	12	.	.	.
cord-275730-650sjwyy	340	1	Upon	upon	IN
cord-275730-650sjwyy	340	2	intratumoral	intratumoral	JJ
cord-275730-650sjwyy	340	3	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	340	4	injection	injection	NN
cord-275730-650sjwyy	340	5	in	in	IN
cord-275730-650sjwyy	340	6	the	the	DT
cord-275730-650sjwyy	340	7	mouse	mouse	NN
cord-275730-650sjwyy	340	8	melanoma	melanoma	NN
cord-275730-650sjwyy	340	9	model	model	NN
cord-275730-650sjwyy	340	10	,	,	,
cord-275730-650sjwyy	340	11	type	type	NN
cord-275730-650sjwyy	340	12	I	-PRON-	PRP
cord-275730-650sjwyy	340	13	IFNs	ifn	NNS
cord-275730-650sjwyy	340	14	were	be	VBD
cord-275730-650sjwyy	340	15	produced	produce	VBN
cord-275730-650sjwyy	340	16	by	by	IN
cord-275730-650sjwyy	340	17	endothelial	endothelial	JJ
cord-275730-650sjwyy	340	18	cells	cell	NNS
cord-275730-650sjwyy	340	19	,	,	,
cord-275730-650sjwyy	340	20	not	not	RB
cord-275730-650sjwyy	340	21	DCs	DCs	NNP
cord-275730-650sjwyy	340	22	[	[	-LRB-
cord-275730-650sjwyy	340	23	27	27	CD
cord-275730-650sjwyy	340	24	]	]	-RRB-
cord-275730-650sjwyy	340	25	.	.	.
cord-275730-650sjwyy	341	1	Similarly	similarly	RB
cord-275730-650sjwyy	341	2	,	,	,
cord-275730-650sjwyy	341	3	endothelial	endothelial	JJ
cord-275730-650sjwyy	341	4	cells	cell	NNS
cord-275730-650sjwyy	341	5	but	but	CC
cord-275730-650sjwyy	341	6	not	not	RB
cord-275730-650sjwyy	341	7	DCs	DCs	NNP
cord-275730-650sjwyy	341	8	were	be	VBD
cord-275730-650sjwyy	341	9	the	the	DT
cord-275730-650sjwyy	341	10	principal	principal	JJ
cord-275730-650sjwyy	341	11	source	source	NN
cord-275730-650sjwyy	341	12	of	of	IN
cord-275730-650sjwyy	341	13	spontaneously	spontaneously	RB
cord-275730-650sjwyy	341	14	induced	induce	VBN
cord-275730-650sjwyy	341	15	type	type	NN
cord-275730-650sjwyy	341	16	I	-PRON-	PRP
cord-275730-650sjwyy	341	17	IFNs	ifns	VBP
cord-275730-650sjwyy	341	18	in	in	IN
cord-275730-650sjwyy	341	19	growing	grow	VBG
cord-275730-650sjwyy	341	20	tumors	tumor	NNS
cord-275730-650sjwyy	341	21	[	[	-LRB-
cord-275730-650sjwyy	341	22	27	27	CD
cord-275730-650sjwyy	341	23	]	]	-RRB-
cord-275730-650sjwyy	341	24	.	.	.
cord-275730-650sjwyy	342	1	Similar	similar	JJ
cord-275730-650sjwyy	342	2	results	result	NNS
cord-275730-650sjwyy	342	3	were	be	VBD
cord-275730-650sjwyy	342	4	obtained	obtain	VBN
cord-275730-650sjwyy	342	5	using	use	VBG
cord-275730-650sjwyy	342	6	an	an	DT
cord-275730-650sjwyy	342	7	ex	ex	FW
cord-275730-650sjwyy	342	8	vivo	vivo	NN
cord-275730-650sjwyy	342	9	model	model	NN
cord-275730-650sjwyy	342	10	of	of	IN
cord-275730-650sjwyy	342	11	cultured	cultured	JJ
cord-275730-650sjwyy	342	12	human	human	JJ
cord-275730-650sjwyy	342	13	melanoma	melanoma	NN
cord-275730-650sjwyy	342	14	explants	explant	NNS
cord-275730-650sjwyy	342	15	[	[	-LRB-
cord-275730-650sjwyy	342	16	27	27	CD
cord-275730-650sjwyy	342	17	]	]	-RRB-
cord-275730-650sjwyy	342	18	,	,	,
cord-275730-650sjwyy	342	19	and	and	CC
cord-275730-650sjwyy	342	20	endothelial	endothelial	JJ
cord-275730-650sjwyy	342	21	STING	sting	NN
cord-275730-650sjwyy	342	22	expression	expression	NN
cord-275730-650sjwyy	342	23	was	be	VBD
cord-275730-650sjwyy	342	24	correlated	correlate	VBN
cord-275730-650sjwyy	342	25	with	with	IN
cord-275730-650sjwyy	342	26	enhanced	enhance	VBN
cord-275730-650sjwyy	342	27	T	t	NN
cord-275730-650sjwyy	342	28	-	-	HYPH
cord-275730-650sjwyy	342	29	cell	cell	NN
cord-275730-650sjwyy	342	30	infiltration	infiltration	NN
cord-275730-650sjwyy	342	31	and	and	CC
cord-275730-650sjwyy	342	32	prolonged	prolong	VBN
cord-275730-650sjwyy	342	33	survival	survival	NN
cord-275730-650sjwyy	342	34	in	in	IN
cord-275730-650sjwyy	342	35	human	human	JJ
cord-275730-650sjwyy	342	36	colon	colon	NN
cord-275730-650sjwyy	342	37	and	and	CC
cord-275730-650sjwyy	342	38	breast	breast	NN
cord-275730-650sjwyy	342	39	cancer	cancer	NN
cord-275730-650sjwyy	342	40	[	[	-LRB-
cord-275730-650sjwyy	342	41	79	79	CD
cord-275730-650sjwyy	342	42	]	]	-RRB-
cord-275730-650sjwyy	342	43	.	.	.
cord-275730-650sjwyy	343	1	It	-PRON-	PRP
cord-275730-650sjwyy	343	2	was	be	VBD
cord-275730-650sjwyy	343	3	suggested	suggest	VBN
cord-275730-650sjwyy	343	4	that	that	IN
cord-275730-650sjwyy	343	5	endothelial	endothelial	JJ
cord-275730-650sjwyy	343	6	cells	cell	NNS
cord-275730-650sjwyy	343	7	initiate	initiate	VBP
cord-275730-650sjwyy	343	8	spontaneous	spontaneous	JJ
cord-275730-650sjwyy	343	9	and	and	CC
cord-275730-650sjwyy	343	10	therapeutic	therapeutic	JJ
cord-275730-650sjwyy	343	11	anti	anti	JJ
cord-275730-650sjwyy	343	12	-	-	JJ
cord-275730-650sjwyy	343	13	tumor	tumor	JJ
cord-275730-650sjwyy	343	14	immunity	immunity	NN
cord-275730-650sjwyy	343	15	of	of	IN
cord-275730-650sjwyy	343	16	CDN	CDN	NNP
cord-275730-650sjwyy	343	17	[	[	-LRB-
cord-275730-650sjwyy	343	18	27	27	CD
cord-275730-650sjwyy	343	19	,	,	,
cord-275730-650sjwyy	343	20	79	79	CD
cord-275730-650sjwyy	343	21	]	]	-RRB-
cord-275730-650sjwyy	343	22	.	.	.
cord-275730-650sjwyy	344	1	Cancer	cancer	NN
cord-275730-650sjwyy	344	2	-	-	HYPH
cord-275730-650sjwyy	344	3	associated	associate	VBN
cord-275730-650sjwyy	344	4	fibroblasts	fibroblast	NNS
cord-275730-650sjwyy	344	5	(	(	-LRB-
cord-275730-650sjwyy	344	6	CAFs	CAFs	NNP
cord-275730-650sjwyy	344	7	)	)	-RRB-
cord-275730-650sjwyy	344	8	and	and	CC
cord-275730-650sjwyy	344	9	cancer	cancer	NN
cord-275730-650sjwyy	344	10	infiltrating	infiltrate	VBG
cord-275730-650sjwyy	344	11	macrophages	macrophage	NNS
cord-275730-650sjwyy	344	12	also	also	RB
cord-275730-650sjwyy	344	13	produce	produce	VBP
cord-275730-650sjwyy	344	14	type	type	NN
cord-275730-650sjwyy	344	15	I	-PRON-	PRP
cord-275730-650sjwyy	344	16	IFNs	ifns	VBP
cord-275730-650sjwyy	344	17	[	[	-LRB-
cord-275730-650sjwyy	344	18	85	85	CD
cord-275730-650sjwyy	344	19	]	]	-RRB-
cord-275730-650sjwyy	344	20	.	.	.
cord-275730-650sjwyy	345	1	Following	follow	VBG
cord-275730-650sjwyy	345	2	transcytosis	transcytosis	NN
cord-275730-650sjwyy	345	3	of	of	IN
cord-275730-650sjwyy	345	4	cytoplasm	cytoplasm	NNP
cord-275730-650sjwyy	345	5	(	(	-LRB-
cord-275730-650sjwyy	345	6	likely	likely	RB
cord-275730-650sjwyy	345	7	containing	contain	VBG
cord-275730-650sjwyy	345	8	cGAMP	cGAMP	NNS
cord-275730-650sjwyy	345	9	)	)	-RRB-
cord-275730-650sjwyy	345	10	from	from	IN
cord-275730-650sjwyy	345	11	cancer	cancer	NN
cord-275730-650sjwyy	345	12	cells	cell	NNS
cord-275730-650sjwyy	345	13	into	into	IN
cord-275730-650sjwyy	345	14	CAFs	CAFs	NNP
cord-275730-650sjwyy	345	15	,	,	,
cord-275730-650sjwyy	345	16	the	the	DT
cord-275730-650sjwyy	345	17	STING	sting	NN
cord-275730-650sjwyy	345	18	pathway	pathway	NN
cord-275730-650sjwyy	345	19	was	be	VBD
cord-275730-650sjwyy	345	20	activated	activate	VBN
cord-275730-650sjwyy	345	21	,	,	,
cord-275730-650sjwyy	345	22	and	and	CC
cord-275730-650sjwyy	345	23	IFNβ1	ifnβ1	PRP
cord-275730-650sjwyy	345	24	was	be	VBD
cord-275730-650sjwyy	345	25	produced	produce	VBN
cord-275730-650sjwyy	345	26	in	in	IN
cord-275730-650sjwyy	345	27	CAFs	CAFs	NNP
cord-275730-650sjwyy	345	28	.	.	.
cord-275730-650sjwyy	346	1	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	346	2	then	then	RB
cord-275730-650sjwyy	346	3	drives	drive	VBZ
cord-275730-650sjwyy	346	4	interferon	interferon	NN
cord-275730-650sjwyy	346	5	-	-	HYPH
cord-275730-650sjwyy	346	6	stimulated	stimulate	VBN
cord-275730-650sjwyy	346	7	transcriptional	transcriptional	JJ
cord-275730-650sjwyy	346	8	programs	program	NNS
cord-275730-650sjwyy	346	9	in	in	IN
cord-275730-650sjwyy	346	10	both	both	DT
cord-275730-650sjwyy	346	11	cancer	cancer	NN
cord-275730-650sjwyy	346	12	cells	cell	NNS
cord-275730-650sjwyy	346	13	and	and	CC
cord-275730-650sjwyy	346	14	CAFs	CAFs	NNP
cord-275730-650sjwyy	346	15	[	[	-LRB-
cord-275730-650sjwyy	346	16	85	85	CD
cord-275730-650sjwyy	346	17	]	]	-RRB-
cord-275730-650sjwyy	346	18	.	.	.
cord-275730-650sjwyy	347	1	Intratumoral	Intratumoral	NNP
cord-275730-650sjwyy	347	2	administration	administration	NN
cord-275730-650sjwyy	347	3	of	of	IN
cord-275730-650sjwyy	347	4	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	347	5	recruited	recruit	VBD
cord-275730-650sjwyy	347	6	CD45	CD45	NNP
cord-275730-650sjwyy	348	1	+	+	CC
cord-275730-650sjwyy	349	1	CD11b	CD11b	NNS
cord-275730-650sjwyy	350	1	mid	mid	NNP
cord-275730-650sjwyy	350	2	Ly6C	Ly6C	NNP
cord-275730-650sjwyy	350	3	+	+	CC
cord-275730-650sjwyy	350	4	cell	cell	NN
cord-275730-650sjwyy	350	5	subset	subset	JJ
cord-275730-650sjwyy	350	6	to	to	IN
cord-275730-650sjwyy	350	7	mouse	mouse	NN
cord-275730-650sjwyy	350	8	tumor	tumor	NN
cord-275730-650sjwyy	350	9	microenvironment	microenvironment	NN
cord-275730-650sjwyy	350	10	of	of	IN
cord-275730-650sjwyy	350	11	4T1	4t1	CD
cord-275730-650sjwyy	350	12	breast	breast	NN
cord-275730-650sjwyy	350	13	cancer	cancer	NN
cord-275730-650sjwyy	350	14	,	,	,
cord-275730-650sjwyy	350	15	squamous	squamous	JJ
cord-275730-650sjwyy	350	16	cell	cell	NN
cord-275730-650sjwyy	350	17	carcinomas	carcinoma	NNS
cord-275730-650sjwyy	350	18	,	,	,
cord-275730-650sjwyy	350	19	CT26	CT26	NNP
cord-275730-650sjwyy	350	20	colon	colon	NN
cord-275730-650sjwyy	350	21	cancer	cancer	NN
cord-275730-650sjwyy	350	22	,	,	,
cord-275730-650sjwyy	350	23	or	or	CC
cord-275730-650sjwyy	350	24	B16F10	b16f10	JJ
cord-275730-650sjwyy	350	25	melanoma	melanoma	NN
cord-275730-650sjwyy	350	26	tissue	tissue	NN
cord-275730-650sjwyy	350	27	[	[	-LRB-
cord-275730-650sjwyy	350	28	28	28	CD
cord-275730-650sjwyy	350	29	]	]	-RRB-
cord-275730-650sjwyy	350	30	.	.	.
cord-275730-650sjwyy	351	1	The	the	DT
cord-275730-650sjwyy	351	2	infiltrating	infiltrate	VBG
cord-275730-650sjwyy	351	3	cells	cell	NNS
cord-275730-650sjwyy	351	4	express	express	VBP
cord-275730-650sjwyy	351	5	F4/80	F4/80	NNP
cord-275730-650sjwyy	351	6	,	,	,
cord-275730-650sjwyy	351	7	MHC	MHC	NNP
cord-275730-650sjwyy	351	8	class	class	NN
cord-275730-650sjwyy	351	9	II	II	NNP
cord-275730-650sjwyy	351	10	,	,	,
cord-275730-650sjwyy	351	11	and	and	CC
cord-275730-650sjwyy	351	12	secreted	secrete	VBN
cord-275730-650sjwyy	351	13	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	351	14	,	,	,
cord-275730-650sjwyy	351	15	as	as	RB
cord-275730-650sjwyy	351	16	well	well	RB
cord-275730-650sjwyy	351	17	as	as	IN
cord-275730-650sjwyy	351	18	TNFα	TNFα	NNP
cord-275730-650sjwyy	351	19	,	,	,
cord-275730-650sjwyy	351	20	T	T	NNP
cord-275730-650sjwyy	351	21	cell	cell	NN
cord-275730-650sjwyy	351	22	-	-	HYPH
cord-275730-650sjwyy	351	23	recruiting	recruit	VBG
cord-275730-650sjwyy	351	24	chemokines	chemokine	NNS
cord-275730-650sjwyy	351	25	,	,	,
cord-275730-650sjwyy	351	26	CXCL10	CXCL10	NNP
cord-275730-650sjwyy	351	27	,	,	,
cord-275730-650sjwyy	351	28	and	and	CC
cord-275730-650sjwyy	351	29	CXCL1	CXCL1	NNP
cord-275730-650sjwyy	351	30	[	[	-LRB-
cord-275730-650sjwyy	351	31	28	28	CD
cord-275730-650sjwyy	351	32	]	]	-RRB-
cord-275730-650sjwyy	351	33	.	.	.
cord-275730-650sjwyy	352	1	Lastly	lastly	RB
cord-275730-650sjwyy	352	2	,	,	,
cord-275730-650sjwyy	352	3	though	though	IN
cord-275730-650sjwyy	352	4	local	local	JJ
cord-275730-650sjwyy	352	5	activation	activation	NN
cord-275730-650sjwyy	352	6	of	of	IN
cord-275730-650sjwyy	352	7	tumor	tumor	NN
cord-275730-650sjwyy	352	8	-	-	HYPH
cord-275730-650sjwyy	352	9	specific	specific	JJ
cord-275730-650sjwyy	352	10	CD8	CD8	NNP
cord-275730-650sjwyy	352	11	+	+	CC
cord-275730-650sjwyy	352	12	effector	effector	VB
cord-275730-650sjwyy	352	13	T	t	NN
cord-275730-650sjwyy	352	14	cells	cell	NNS
cord-275730-650sjwyy	352	15	is	be	VBZ
cord-275730-650sjwyy	352	16	responsible	responsible	JJ
cord-275730-650sjwyy	352	17	for	for	IN
cord-275730-650sjwyy	352	18	durable	durable	JJ
cord-275730-650sjwyy	352	19	anti	anti	JJ
cord-275730-650sjwyy	352	20	-	-	JJ
cord-275730-650sjwyy	352	21	tumor	tumor	JJ
cord-275730-650sjwyy	352	22	immunity	immunity	NN
cord-275730-650sjwyy	352	23	by	by	IN
cord-275730-650sjwyy	352	24	CDNs	cdn	NNS
cord-275730-650sjwyy	352	25	via	via	IN
cord-275730-650sjwyy	352	26	type	type	NN
cord-275730-650sjwyy	352	27	I	-PRON-	PRP
cord-275730-650sjwyy	352	28	IFNs	ifns	VBP
cord-275730-650sjwyy	352	29	production	production	NN
cord-275730-650sjwyy	352	30	[	[	-LRB-
cord-275730-650sjwyy	352	31	62	62	CD
cord-275730-650sjwyy	352	32	]	]	-RRB-
cord-275730-650sjwyy	352	33	,	,	,
cord-275730-650sjwyy	352	34	CDNs	CDNs	NNP
cord-275730-650sjwyy	352	35	also	also	RB
cord-275730-650sjwyy	352	36	activate	activate	VBP
cord-275730-650sjwyy	352	37	NK	NK	NNP
cord-275730-650sjwyy	352	38	cells	cell	NNS
cord-275730-650sjwyy	352	39	to	to	TO
cord-275730-650sjwyy	352	40	kill	kill	VB
cord-275730-650sjwyy	352	41	CD8	CD8	NNP
cord-275730-650sjwyy	352	42	+	+	CC
cord-275730-650sjwyy	352	43	T	T	NNP
cord-275730-650sjwyy	352	44	cell	cell	NN
cord-275730-650sjwyy	352	45	-	-	HYPH
cord-275730-650sjwyy	352	46	resistant	resistant	JJ
cord-275730-650sjwyy	352	47	tumors	tumor	NNS
cord-275730-650sjwyy	352	48	[	[	-LRB-
cord-275730-650sjwyy	352	49	29	29	CD
cord-275730-650sjwyy	352	50	,	,	,
cord-275730-650sjwyy	352	51	86	86	CD
cord-275730-650sjwyy	352	52	]	]	-RRB-
cord-275730-650sjwyy	352	53	.	.	.
cord-275730-650sjwyy	353	1	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	353	2	administration	administration	NN
cord-275730-650sjwyy	353	3	triggered	trigger	VBD
cord-275730-650sjwyy	353	4	STING	STING	NNP
cord-275730-650sjwyy	353	5	activation	activation	NN
cord-275730-650sjwyy	353	6	and	and	CC
cord-275730-650sjwyy	353	7	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	353	8	production	production	NN
cord-275730-650sjwyy	353	9	in	in	IN
cord-275730-650sjwyy	353	10	myeloid	myeloid	JJ
cord-275730-650sjwyy	353	11	cells	cell	NNS
cord-275730-650sjwyy	353	12	and	and	CC
cord-275730-650sjwyy	353	13	B	b	NN
cord-275730-650sjwyy	353	14	cells	cell	NNS
cord-275730-650sjwyy	353	15	but	but	CC
cord-275730-650sjwyy	353	16	not	not	RB
cord-275730-650sjwyy	353	17	NK	NK	NNP
cord-275730-650sjwyy	353	18	cells	cell	NNS
cord-275730-650sjwyy	353	19	[	[	-LRB-
cord-275730-650sjwyy	353	20	86	86	CD
cord-275730-650sjwyy	353	21	]	]	-RRB-
cord-275730-650sjwyy	353	22	.	.	.
cord-275730-650sjwyy	354	1	Type	type	NN
cord-275730-650sjwyy	354	2	I	-PRON-	PRP
cord-275730-650sjwyy	354	3	IFNs	ifn	NNS
cord-275730-650sjwyy	354	4	then	then	RB
cord-275730-650sjwyy	354	5	activate	activate	VB
cord-275730-650sjwyy	354	6	the	the	DT
cord-275730-650sjwyy	354	7	NK	NK	NNP
cord-275730-650sjwyy	354	8	cell	cell	NN
cord-275730-650sjwyy	354	9	to	to	TO
cord-275730-650sjwyy	354	10	kill	kill	VB
cord-275730-650sjwyy	354	11	tumor	tumor	NN
cord-275730-650sjwyy	354	12	cells	cell	NNS
cord-275730-650sjwyy	354	13	[	[	-LRB-
cord-275730-650sjwyy	354	14	29	29	CD
cord-275730-650sjwyy	354	15	,	,	,
cord-275730-650sjwyy	354	16	86	86	CD
cord-275730-650sjwyy	354	17	]	]	-RRB-
cord-275730-650sjwyy	354	18	.	.	.
cord-275730-650sjwyy	355	1	In	in	IN
cord-275730-650sjwyy	355	2	all	all	DT
cord-275730-650sjwyy	355	3	,	,	,
cord-275730-650sjwyy	355	4	STING	sting	VB
cord-275730-650sjwyy	355	5	in	in	IN
cord-275730-650sjwyy	355	6	non	non	JJ
cord-275730-650sjwyy	355	7	-	-	JJ
cord-275730-650sjwyy	355	8	hematopoietic	hematopoietic	JJ
cord-275730-650sjwyy	355	9	cells	cell	NNS
cord-275730-650sjwyy	355	10	and	and	CC
cord-275730-650sjwyy	355	11	hematopoietic	hematopoietic	JJ
cord-275730-650sjwyy	355	12	cells	cell	NNS
cord-275730-650sjwyy	355	13	are	be	VBP
cord-275730-650sjwyy	355	14	needed	need	VBN
cord-275730-650sjwyy	355	15	for	for	IN
cord-275730-650sjwyy	355	16	the	the	DT
cord-275730-650sjwyy	355	17	maximal	maximal	JJ
cord-275730-650sjwyy	355	18	therapeutic	therapeutic	JJ
cord-275730-650sjwyy	355	19	efficacy	efficacy	NN
cord-275730-650sjwyy	355	20	of	of	IN
cord-275730-650sjwyy	355	21	CDNs	CDNs	NNP
cord-275730-650sjwyy	355	22	[	[	-LRB-
cord-275730-650sjwyy	355	23	79	79	CD
cord-275730-650sjwyy	355	24	]	]	-RRB-
cord-275730-650sjwyy	355	25	(	(	-LRB-
cord-275730-650sjwyy	355	26	Figure	figure	NN
cord-275730-650sjwyy	355	27	3	3	CD
cord-275730-650sjwyy	355	28	)	)	-RRB-
cord-275730-650sjwyy	355	29	.	.	.
cord-275730-650sjwyy	356	1	In	in	IN
cord-275730-650sjwyy	356	2	vivo	vivo	NNP
cord-275730-650sjwyy	356	3	CDN	CDN	NNP
cord-275730-650sjwyy	356	4	-	-	HYPH
cord-275730-650sjwyy	356	5	induced	induce	VBN
cord-275730-650sjwyy	356	6	,	,	,
cord-275730-650sjwyy	356	7	type	type	NN
cord-275730-650sjwyy	356	8	I	-PRON-	PRP
cord-275730-650sjwyy	356	9	IFNs	ifns	NN
cord-275730-650sjwyy	356	10	-	-	HYPH
cord-275730-650sjwyy	356	11	mediated	mediate	VBN
cord-275730-650sjwyy	356	12	anti	anti	JJ
cord-275730-650sjwyy	356	13	-	-	JJ
cord-275730-650sjwyy	356	14	tumor	tumor	JJ
cord-275730-650sjwyy	356	15	immunity	immunity	NN
cord-275730-650sjwyy	356	16	.	.	.
cord-275730-650sjwyy	357	1	The	the	DT
cord-275730-650sjwyy	357	2	CDN	CDN	NNP
cord-275730-650sjwyy	357	3	immunization	immunization	NN
cord-275730-650sjwyy	357	4	in	in	IN
cord-275730-650sjwyy	357	5	the	the	DT
cord-275730-650sjwyy	357	6	tumor	tumor	NN
cord-275730-650sjwyy	357	7	microenvironment	microenvironment	NN
cord-275730-650sjwyy	357	8	(	(	-LRB-
cord-275730-650sjwyy	357	9	TME	TME	NNP
cord-275730-650sjwyy	357	10	)	)	-RRB-
cord-275730-650sjwyy	357	11	activates	activate	VBZ
cord-275730-650sjwyy	357	12	the	the	DT
cord-275730-650sjwyy	357	13	STING	sting	NN
cord-275730-650sjwyy	357	14	pathway	pathway	NN
cord-275730-650sjwyy	357	15	in	in	IN
cord-275730-650sjwyy	357	16	DCs	DCs	NNP
cord-275730-650sjwyy	357	17	,	,	,
cord-275730-650sjwyy	357	18	endothelial	endothelial	JJ
cord-275730-650sjwyy	357	19	cells	cell	NNS
cord-275730-650sjwyy	357	20	,	,	,
cord-275730-650sjwyy	357	21	fibroblasts	fibroblast	NNS
cord-275730-650sjwyy	357	22	,	,	,
cord-275730-650sjwyy	357	23	and	and	CC
cord-275730-650sjwyy	357	24	myeloid	myeloid	NN
cord-275730-650sjwyy	357	25	cells	cell	NNS
cord-275730-650sjwyy	357	26	,	,	,
cord-275730-650sjwyy	357	27	leading	lead	VBG
cord-275730-650sjwyy	357	28	to	to	IN
cord-275730-650sjwyy	357	29	the	the	DT
cord-275730-650sjwyy	357	30	production	production	NN
cord-275730-650sjwyy	357	31	of	of	IN
cord-275730-650sjwyy	357	32	type	type	NN
cord-275730-650sjwyy	357	33	I	-PRON-	PRP
cord-275730-650sjwyy	357	34	IFNs	ifns	VBP
cord-275730-650sjwyy	357	35	.	.	.
cord-275730-650sjwyy	358	1	Type	type	NN
cord-275730-650sjwyy	358	2	I	I	NNP
cord-275730-650sjwyy	358	3	IFNs	ifn	NNS
cord-275730-650sjwyy	358	4	act	act	NN
cord-275730-650sjwyy	358	5	as	as	IN
cord-275730-650sjwyy	358	6	a	a	DT
cord-275730-650sjwyy	358	7	stimulus	stimulus	NN
cord-275730-650sjwyy	358	8	for	for	IN
cord-275730-650sjwyy	358	9	DC	DC	NNP
cord-275730-650sjwyy	358	10	to	to	TO
cord-275730-650sjwyy	358	11	induce	induce	VB
cord-275730-650sjwyy	358	12	CD8	CD8	NNP
cord-275730-650sjwyy	358	13	+	+	CC
cord-275730-650sjwyy	358	14	T	T	NNP
cord-275730-650sjwyy	358	15	cell	cell	NN
cord-275730-650sjwyy	358	16	cross	cross	NN
cord-275730-650sjwyy	358	17	-	-	JJ
cord-275730-650sjwyy	358	18	priming	priming	NN
cord-275730-650sjwyy	358	19	.	.	.
cord-275730-650sjwyy	359	1	Type	type	NN
cord-275730-650sjwyy	359	2	I	-PRON-	PRP
cord-275730-650sjwyy	359	3	IFNs	ifn	NNS
cord-275730-650sjwyy	359	4	also	also	RB
cord-275730-650sjwyy	359	5	activate	activate	VBP
cord-275730-650sjwyy	359	6	natural	natural	JJ
cord-275730-650sjwyy	359	7	killer	killer	NN
cord-275730-650sjwyy	359	8	(	(	-LRB-
cord-275730-650sjwyy	359	9	NK	NK	NNP
cord-275730-650sjwyy	359	10	)	)	-RRB-
cord-275730-650sjwyy	359	11	cells	cell	NNS
cord-275730-650sjwyy	359	12	leading	lead	VBG
cord-275730-650sjwyy	359	13	to	to	IN
cord-275730-650sjwyy	359	14	NK	NK	NNP
cord-275730-650sjwyy	359	15	cell	cell	NN
cord-275730-650sjwyy	359	16	-	-	HYPH
cord-275730-650sjwyy	359	17	mediated	mediate	VBN
cord-275730-650sjwyy	359	18	cytotoxicity	cytotoxicity	NN
cord-275730-650sjwyy	359	19	and	and	CC
cord-275730-650sjwyy	359	20	tumor	tumor	NN
cord-275730-650sjwyy	359	21	cell	cell	NN
cord-275730-650sjwyy	359	22	killing	killing	NN
cord-275730-650sjwyy	359	23	.	.	.
cord-275730-650sjwyy	360	1	The	the	DT
cord-275730-650sjwyy	360	2	tolerogenic	tolerogenic	JJ
cord-275730-650sjwyy	360	3	responses	response	NNS
cord-275730-650sjwyy	360	4	induced	induce	VBN
cord-275730-650sjwyy	360	5	by	by	IN
cord-275730-650sjwyy	360	6	DNPs	dnp	NNS
cord-275730-650sjwyy	360	7	and	and	CC
cord-275730-650sjwyy	360	8	CDNs	cdn	NNS
cord-275730-650sjwyy	360	9	depend	depend	VBP
cord-275730-650sjwyy	360	10	on	on	IN
cord-275730-650sjwyy	360	11	STING	sting	NN
cord-275730-650sjwyy	360	12	and	and	CC
cord-275730-650sjwyy	360	13	IFN	IFN	NNP
cord-275730-650sjwyy	360	14	-	-	HYPH
cord-275730-650sjwyy	360	15	αβ	αβ	NN
cord-275730-650sjwyy	360	16	receptor	receptor	NN
cord-275730-650sjwyy	360	17	genes	gene	NNS
cord-275730-650sjwyy	360	18	,	,	,
cord-275730-650sjwyy	360	19	but	but	CC
cord-275730-650sjwyy	360	20	not	not	RB
cord-275730-650sjwyy	360	21	IFNγ	IFNγ	VBZ
cord-275730-650sjwyy	360	22	receptor	receptor	NN
cord-275730-650sjwyy	360	23	genes	gene	NNS
cord-275730-650sjwyy	360	24	[	[	-LRB-
cord-275730-650sjwyy	360	25	45	45	CD
cord-275730-650sjwyy	360	26	]	]	-RRB-
cord-275730-650sjwyy	360	27	.	.	.
cord-275730-650sjwyy	361	1	CD11b	CD11b	NNS
cord-275730-650sjwyy	361	2	+	+	CC
cord-275730-650sjwyy	361	3	DCs	dc	NNS
cord-275730-650sjwyy	361	4	were	be	VBD
cord-275730-650sjwyy	361	5	identified	identify	VBN
cord-275730-650sjwyy	361	6	as	as	IN
cord-275730-650sjwyy	361	7	the	the	DT
cord-275730-650sjwyy	361	8	only	only	JJ
cord-275730-650sjwyy	361	9	cells	cell	NNS
cord-275730-650sjwyy	361	10	to	to	TO
cord-275730-650sjwyy	361	11	produce	produce	VB
cord-275730-650sjwyy	361	12	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	361	13	[	[	-LRB-
cord-275730-650sjwyy	361	14	44	44	CD
cord-275730-650sjwyy	361	15	]	]	-RRB-
cord-275730-650sjwyy	361	16	.	.	.
cord-275730-650sjwyy	362	1	The	the	DT
cord-275730-650sjwyy	362	2	CD11b	CD11b	NNPS
cord-275730-650sjwyy	362	3	+	+	SYM
cord-275730-650sjwyy	362	4	DCs	dc	NNS
cord-275730-650sjwyy	362	5	consist	consist	VBP
cord-275730-650sjwyy	362	6	of	of	IN
cord-275730-650sjwyy	362	7	cDC2	cDC2	NNP
cord-275730-650sjwyy	362	8	and	and	CC
cord-275730-650sjwyy	362	9	moDCs	moDCs	NNP
cord-275730-650sjwyy	362	10	.	.	.
cord-275730-650sjwyy	363	1	It	-PRON-	PRP
cord-275730-650sjwyy	363	2	is	be	VBZ
cord-275730-650sjwyy	363	3	unknown	unknown	JJ
cord-275730-650sjwyy	363	4	(	(	-LRB-
cord-275730-650sjwyy	364	1	i	i	PRP
cord-275730-650sjwyy	364	2	)	)	-RRB-
cord-275730-650sjwyy	364	3	which	which	WDT
cord-275730-650sjwyy	364	4	DCs	DCs	NNP
cord-275730-650sjwyy	364	5	subset	subset	NNP
cord-275730-650sjwyy	364	6	is	be	VBZ
cord-275730-650sjwyy	364	7	responsible	responsible	JJ
cord-275730-650sjwyy	364	8	for	for	IN
cord-275730-650sjwyy	364	9	the	the	DT
cord-275730-650sjwyy	364	10	CDN	CDN	NNP
cord-275730-650sjwyy	364	11	tolerogenic	tolerogenic	NNP
cord-275730-650sjwyy	364	12	function	function	NN
cord-275730-650sjwyy	364	13	;	;	:
cord-275730-650sjwyy	364	14	(	(	-LRB-
cord-275730-650sjwyy	364	15	ii	ii	NN
cord-275730-650sjwyy	364	16	)	)	-RRB-
cord-275730-650sjwyy	365	1	the	the	DT
cord-275730-650sjwyy	365	2	unique	unique	JJ
cord-275730-650sjwyy	365	3	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	365	4	signaling	signal	VBG
cord-275730-650sjwyy	365	5	that	that	WDT
cord-275730-650sjwyy	365	6	induces	induce	VBZ
cord-275730-650sjwyy	365	7	T	t	NN
cord-275730-650sjwyy	365	8	-	-	HYPH
cord-275730-650sjwyy	365	9	regs	reg	NNS
cord-275730-650sjwyy	365	10	production	production	NN
cord-275730-650sjwyy	365	11	.	.	.
cord-275730-650sjwyy	366	1	In	in	IN
cord-275730-650sjwyy	366	2	vivo	vivo	NNP
cord-275730-650sjwyy	366	3	CDN	CDN	NNP
cord-275730-650sjwyy	366	4	-	-	HYPH
cord-275730-650sjwyy	366	5	induced	induce	VBN
cord-275730-650sjwyy	366	6	,	,	,
cord-275730-650sjwyy	366	7	type	type	NN
cord-275730-650sjwyy	366	8	I	-PRON-	PRP
cord-275730-650sjwyy	366	9	IFNs	ifns	NN
cord-275730-650sjwyy	366	10	-	-	HYPH
cord-275730-650sjwyy	366	11	mediated	mediate	VBN
cord-275730-650sjwyy	366	12	anti	anti	JJ
cord-275730-650sjwyy	366	13	-	-	JJ
cord-275730-650sjwyy	366	14	tumor	tumor	JJ
cord-275730-650sjwyy	366	15	immunity	immunity	NN
cord-275730-650sjwyy	366	16	.	.	.
cord-275730-650sjwyy	367	1	The	the	DT
cord-275730-650sjwyy	367	2	CDN	CDN	NNP
cord-275730-650sjwyy	367	3	immunization	immunization	NN
cord-275730-650sjwyy	367	4	in	in	IN
cord-275730-650sjwyy	367	5	the	the	DT
cord-275730-650sjwyy	367	6	tumor	tumor	NN
cord-275730-650sjwyy	367	7	microenvironment	microenvironment	NN
cord-275730-650sjwyy	367	8	(	(	-LRB-
cord-275730-650sjwyy	367	9	TME	TME	NNP
cord-275730-650sjwyy	367	10	)	)	-RRB-
cord-275730-650sjwyy	367	11	activates	activate	VBZ
cord-275730-650sjwyy	367	12	the	the	DT
cord-275730-650sjwyy	367	13	STING	sting	NN
cord-275730-650sjwyy	367	14	pathway	pathway	NN
cord-275730-650sjwyy	367	15	in	in	IN
cord-275730-650sjwyy	367	16	DCs	DCs	NNP
cord-275730-650sjwyy	367	17	,	,	,
cord-275730-650sjwyy	367	18	endothelial	endothelial	JJ
cord-275730-650sjwyy	367	19	cells	cell	NNS
cord-275730-650sjwyy	367	20	,	,	,
cord-275730-650sjwyy	367	21	fibroblasts	fibroblast	NNS
cord-275730-650sjwyy	367	22	,	,	,
cord-275730-650sjwyy	367	23	and	and	CC
cord-275730-650sjwyy	367	24	myeloid	myeloid	NN
cord-275730-650sjwyy	367	25	cells	cell	NNS
cord-275730-650sjwyy	367	26	,	,	,
cord-275730-650sjwyy	367	27	leading	lead	VBG
cord-275730-650sjwyy	367	28	to	to	IN
cord-275730-650sjwyy	367	29	the	the	DT
cord-275730-650sjwyy	367	30	production	production	NN
cord-275730-650sjwyy	367	31	of	of	IN
cord-275730-650sjwyy	367	32	type	type	NN
cord-275730-650sjwyy	367	33	I	-PRON-	PRP
cord-275730-650sjwyy	367	34	IFNs	ifns	VBP
cord-275730-650sjwyy	367	35	.	.	.
cord-275730-650sjwyy	368	1	Type	type	NN
cord-275730-650sjwyy	368	2	I	I	NNP
cord-275730-650sjwyy	368	3	IFNs	ifn	NNS
cord-275730-650sjwyy	368	4	act	act	NN
cord-275730-650sjwyy	368	5	as	as	IN
cord-275730-650sjwyy	368	6	a	a	DT
cord-275730-650sjwyy	368	7	stimulus	stimulus	NN
cord-275730-650sjwyy	368	8	for	for	IN
cord-275730-650sjwyy	368	9	DC	DC	NNP
cord-275730-650sjwyy	368	10	to	to	TO
cord-275730-650sjwyy	368	11	induce	induce	VB
cord-275730-650sjwyy	368	12	CD8	CD8	NNP
cord-275730-650sjwyy	368	13	+	+	CC
cord-275730-650sjwyy	368	14	T	T	NNP
cord-275730-650sjwyy	368	15	cell	cell	NN
cord-275730-650sjwyy	368	16	cross	cross	NN
cord-275730-650sjwyy	368	17	-	-	JJ
cord-275730-650sjwyy	368	18	priming	priming	NN
cord-275730-650sjwyy	368	19	.	.	.
cord-275730-650sjwyy	369	1	Type	type	NN
cord-275730-650sjwyy	369	2	I	-PRON-	PRP
cord-275730-650sjwyy	369	3	IFNs	ifn	NNS
cord-275730-650sjwyy	369	4	also	also	RB
cord-275730-650sjwyy	369	5	activate	activate	VBP
cord-275730-650sjwyy	369	6	natural	natural	JJ
cord-275730-650sjwyy	369	7	killer	killer	NN
cord-275730-650sjwyy	369	8	(	(	-LRB-
cord-275730-650sjwyy	369	9	NK	NK	NNP
cord-275730-650sjwyy	369	10	)	)	-RRB-
cord-275730-650sjwyy	369	11	cells	cell	NNS
cord-275730-650sjwyy	369	12	leading	lead	VBG
cord-275730-650sjwyy	369	13	to	to	IN
cord-275730-650sjwyy	369	14	NK	NK	NNP
cord-275730-650sjwyy	369	15	cell	cell	NN
cord-275730-650sjwyy	369	16	-	-	HYPH
cord-275730-650sjwyy	369	17	mediated	mediate	VBN
cord-275730-650sjwyy	369	18	cytotoxicity	cytotoxicity	NN
cord-275730-650sjwyy	369	19	and	and	CC
cord-275730-650sjwyy	369	20	tumor	tumor	NN
cord-275730-650sjwyy	369	21	cell	cell	NN
cord-275730-650sjwyy	369	22	killing	killing	NN
cord-275730-650sjwyy	369	23	.	.	.
cord-275730-650sjwyy	370	1	The	the	DT
cord-275730-650sjwyy	370	2	tolerogenic	tolerogenic	JJ
cord-275730-650sjwyy	370	3	responses	response	NNS
cord-275730-650sjwyy	370	4	induced	induce	VBN
cord-275730-650sjwyy	370	5	by	by	IN
cord-275730-650sjwyy	370	6	DNPs	dnp	NNS
cord-275730-650sjwyy	370	7	and	and	CC
cord-275730-650sjwyy	370	8	CDNs	cdn	NNS
cord-275730-650sjwyy	370	9	depend	depend	VBP
cord-275730-650sjwyy	370	10	on	on	IN
cord-275730-650sjwyy	370	11	STING	sting	NN
cord-275730-650sjwyy	370	12	and	and	CC
cord-275730-650sjwyy	370	13	IFN	IFN	NNP
cord-275730-650sjwyy	370	14	-	-	HYPH
cord-275730-650sjwyy	370	15	αβ	αβ	NN
cord-275730-650sjwyy	370	16	receptor	receptor	NN
cord-275730-650sjwyy	370	17	genes	gene	NNS
cord-275730-650sjwyy	370	18	,	,	,
cord-275730-650sjwyy	370	19	but	but	CC
cord-275730-650sjwyy	370	20	not	not	RB
cord-275730-650sjwyy	370	21	IFNγ	IFNγ	VBZ
cord-275730-650sjwyy	370	22	receptor	receptor	NN
cord-275730-650sjwyy	370	23	genes	gene	NNS
cord-275730-650sjwyy	370	24	[	[	-LRB-
cord-275730-650sjwyy	370	25	45	45	CD
cord-275730-650sjwyy	370	26	]	]	-RRB-
cord-275730-650sjwyy	370	27	.	.	.
cord-275730-650sjwyy	371	1	CD11b	CD11b	NNS
cord-275730-650sjwyy	371	2	+	+	CC
cord-275730-650sjwyy	371	3	DCs	dc	NNS
cord-275730-650sjwyy	371	4	were	be	VBD
cord-275730-650sjwyy	371	5	identified	identify	VBN
cord-275730-650sjwyy	371	6	as	as	IN
cord-275730-650sjwyy	371	7	the	the	DT
cord-275730-650sjwyy	371	8	only	only	JJ
cord-275730-650sjwyy	371	9	cells	cell	NNS
cord-275730-650sjwyy	371	10	to	to	TO
cord-275730-650sjwyy	371	11	produce	produce	VB
cord-275730-650sjwyy	371	12	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	371	13	[	[	-LRB-
cord-275730-650sjwyy	371	14	44	44	CD
cord-275730-650sjwyy	371	15	]	]	-RRB-
cord-275730-650sjwyy	371	16	.	.	.
cord-275730-650sjwyy	372	1	The	the	DT
cord-275730-650sjwyy	372	2	CD11b	CD11b	NNPS
cord-275730-650sjwyy	372	3	+	+	SYM
cord-275730-650sjwyy	372	4	DCs	dc	NNS
cord-275730-650sjwyy	372	5	consist	consist	VBP
cord-275730-650sjwyy	372	6	of	of	IN
cord-275730-650sjwyy	372	7	cDC2	cDC2	NNP
cord-275730-650sjwyy	372	8	and	and	CC
cord-275730-650sjwyy	372	9	moDCs	moDCs	NNP
cord-275730-650sjwyy	372	10	.	.	.
cord-275730-650sjwyy	373	1	It	-PRON-	PRP
cord-275730-650sjwyy	373	2	is	be	VBZ
cord-275730-650sjwyy	373	3	unknown	unknown	JJ
cord-275730-650sjwyy	373	4	(	(	-LRB-
cord-275730-650sjwyy	374	1	i	i	PRP
cord-275730-650sjwyy	374	2	)	)	-RRB-
cord-275730-650sjwyy	374	3	which	which	WDT
cord-275730-650sjwyy	374	4	DCs	DCs	NNP
cord-275730-650sjwyy	374	5	subset	subset	NNP
cord-275730-650sjwyy	374	6	is	be	VBZ
cord-275730-650sjwyy	374	7	responsible	responsible	JJ
cord-275730-650sjwyy	374	8	for	for	IN
cord-275730-650sjwyy	374	9	the	the	DT
cord-275730-650sjwyy	374	10	CDN	CDN	NNP
cord-275730-650sjwyy	374	11	tolerogenic	tolerogenic	NNP
cord-275730-650sjwyy	374	12	function	function	NN
cord-275730-650sjwyy	374	13	;	;	:
cord-275730-650sjwyy	374	14	(	(	-LRB-
cord-275730-650sjwyy	374	15	ii	ii	NN
cord-275730-650sjwyy	374	16	)	)	-RRB-
cord-275730-650sjwyy	375	1	the	the	DT
cord-275730-650sjwyy	375	2	unique	unique	JJ
cord-275730-650sjwyy	375	3	IFNβ	IFNβ	NNS
cord-275730-650sjwyy	375	4	signaling	signal	VBG
cord-275730-650sjwyy	375	5	that	that	WDT
cord-275730-650sjwyy	375	6	induces	induce	VBZ
cord-275730-650sjwyy	375	7	T	t	NN
cord-275730-650sjwyy	375	8	-	-	HYPH
cord-275730-650sjwyy	375	9	regs	reg	NNS
cord-275730-650sjwyy	375	10	production	production	NN
cord-275730-650sjwyy	375	11	.	.	.
cord-275730-650sjwyy	376	1	Murine	murine	JJ
cord-275730-650sjwyy	376	2	studies	study	NNS
cord-275730-650sjwyy	376	3	have	have	VBP
cord-275730-650sjwyy	376	4	consistently	consistently	RB
cord-275730-650sjwyy	376	5	shown	show	VBN
cord-275730-650sjwyy	376	6	promising	promising	JJ
cord-275730-650sjwyy	376	7	results	result	NNS
cord-275730-650sjwyy	376	8	for	for	IN
cord-275730-650sjwyy	376	9	CDN	CDN	NNP
cord-275730-650sjwyy	376	10	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	376	11	in	in	IN
cord-275730-650sjwyy	376	12	infectious	infectious	JJ
cord-275730-650sjwyy	376	13	diseases	disease	NNS
cord-275730-650sjwyy	376	14	and	and	CC
cord-275730-650sjwyy	376	15	cancer	cancer	NN
cord-275730-650sjwyy	376	16	therapeutics	therapeutic	NNS
cord-275730-650sjwyy	376	17	.	.	.
cord-275730-650sjwyy	377	1	However	however	RB
cord-275730-650sjwyy	377	2	,	,	,
cord-275730-650sjwyy	377	3	CDN	CDN	NNP
cord-275730-650sjwyy	377	4	human	human	JJ
cord-275730-650sjwyy	377	5	clinical	clinical	JJ
cord-275730-650sjwyy	377	6	trials	trial	NNS
cord-275730-650sjwyy	377	7	have	have	VBP
cord-275730-650sjwyy	377	8	failed	fail	VBN
cord-275730-650sjwyy	377	9	to	to	TO
cord-275730-650sjwyy	377	10	yield	yield	VB
cord-275730-650sjwyy	377	11	the	the	DT
cord-275730-650sjwyy	377	12	desired	desire	VBN
cord-275730-650sjwyy	377	13	effect	effect	NN
cord-275730-650sjwyy	377	14	.	.	.
cord-275730-650sjwyy	378	1	Merck	Merck	NNP
cord-275730-650sjwyy	378	2	's	's	POS
cord-275730-650sjwyy	378	3	synthetic	synthetic	JJ
cord-275730-650sjwyy	378	4	CDN	CDN	NNP
cord-275730-650sjwyy	378	5	MK-1454	MK-1454	NNP
cord-275730-650sjwyy	378	6	(	(	-LRB-
cord-275730-650sjwyy	378	7	NCT03010176	NCT03010176	NNP
cord-275730-650sjwyy	378	8	)	)	-RRB-
cord-275730-650sjwyy	378	9	administered	administer	VBN
cord-275730-650sjwyy	378	10	intratumorally	intratumorally	RB
cord-275730-650sjwyy	378	11	failed	fail	VBD
cord-275730-650sjwyy	378	12	to	to	TO
cord-275730-650sjwyy	378	13	generate	generate	VB
cord-275730-650sjwyy	378	14	any	any	DT
cord-275730-650sjwyy	378	15	response	response	NN
cord-275730-650sjwyy	378	16	against	against	IN
cord-275730-650sjwyy	378	17	metastatic	metastatic	JJ
cord-275730-650sjwyy	378	18	solid	solid	JJ
cord-275730-650sjwyy	378	19	tumors	tumor	NNS
cord-275730-650sjwyy	378	20	patients	patient	NNS
cord-275730-650sjwyy	378	21	(	(	-LRB-
cord-275730-650sjwyy	378	22	head	head	NN
cord-275730-650sjwyy	378	23	and	and	CC
cord-275730-650sjwyy	378	24	neck	neck	NN
cord-275730-650sjwyy	378	25	squamous	squamous	JJ
cord-275730-650sjwyy	378	26	cell	cell	NN
cord-275730-650sjwyy	378	27	carcinoma	carcinoma	NN
cord-275730-650sjwyy	378	28	,	,	,
cord-275730-650sjwyy	378	29	triple	triple	JJ
cord-275730-650sjwyy	378	30	-	-	HYPH
cord-275730-650sjwyy	378	31	negative	negative	JJ
cord-275730-650sjwyy	378	32	breast	breast	NN
cord-275730-650sjwyy	378	33	cancer	cancer	NN
cord-275730-650sjwyy	378	34	,	,	,
cord-275730-650sjwyy	378	35	and	and	CC
cord-275730-650sjwyy	378	36	anaplastic	anaplastic	JJ
cord-275730-650sjwyy	378	37	thyroid	thyroid	NN
cord-275730-650sjwyy	378	38	carcinoma	carcinoma	NN
cord-275730-650sjwyy	378	39	)	)	-RRB-
cord-275730-650sjwyy	378	40	.	.	.
cord-275730-650sjwyy	379	1	Aduro	Aduro	NNP
cord-275730-650sjwyy	379	2	Biotech	Biotech	NNP
cord-275730-650sjwyy	379	3	's	's	POS
cord-275730-650sjwyy	379	4	synthetic	synthetic	JJ
cord-275730-650sjwyy	379	5	CDN	CDN	NNP
cord-275730-650sjwyy	379	6	,	,	,
cord-275730-650sjwyy	379	7	ADU	ADU	NNP
cord-275730-650sjwyy	379	8	-	-	HYPH
cord-275730-650sjwyy	379	9	S100	S100	NNP
cord-275730-650sjwyy	379	10	,	,	,
cord-275730-650sjwyy	379	11	also	also	RB
cord-275730-650sjwyy	379	12	had	have	VBD
cord-275730-650sjwyy	379	13	disappointing	disappointing	JJ
cord-275730-650sjwyy	379	14	clinical	clinical	JJ
cord-275730-650sjwyy	379	15	responses	response	NNS
cord-275730-650sjwyy	379	16	(	(	-LRB-
cord-275730-650sjwyy	379	17	weak	weak	JJ
cord-275730-650sjwyy	379	18	response	response	NN
cord-275730-650sjwyy	379	19	in	in	IN
cord-275730-650sjwyy	379	20	only	only	RB
cord-275730-650sjwyy	379	21	5	5	CD
cord-275730-650sjwyy	379	22	%	%	NN
cord-275730-650sjwyy	379	23	of	of	IN
cord-275730-650sjwyy	379	24	the	the	DT
cord-275730-650sjwyy	379	25	treated	treat	VBN
cord-275730-650sjwyy	379	26	patients	patient	NNS
cord-275730-650sjwyy	379	27	)	)	-RRB-
cord-275730-650sjwyy	379	28	(	(	-LRB-
cord-275730-650sjwyy	379	29	NCT02675439	NCT02675439	NNP
cord-275730-650sjwyy	379	30	)	)	-RRB-
cord-275730-650sjwyy	379	31	.	.	.
cord-275730-650sjwyy	380	1	Two	two	CD
cord-275730-650sjwyy	380	2	confounding	confounding	JJ
cord-275730-650sjwyy	380	3	factors	factor	NNS
cord-275730-650sjwyy	380	4	may	may	MD
cord-275730-650sjwyy	380	5	explain	explain	VB
cord-275730-650sjwyy	380	6	the	the	DT
cord-275730-650sjwyy	380	7	ineffectiveness	ineffectiveness	NN
cord-275730-650sjwyy	380	8	of	of	IN
cord-275730-650sjwyy	380	9	CDNs	cdn	NNS
cord-275730-650sjwyy	380	10	in	in	IN
cord-275730-650sjwyy	380	11	humans	human	NNS
cord-275730-650sjwyy	380	12	.	.	.
cord-275730-650sjwyy	381	1	The	the	DT
cord-275730-650sjwyy	381	2	CDN	CDN	NNP
cord-275730-650sjwyy	381	3	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	381	4	depends	depend	VBZ
cord-275730-650sjwyy	381	5	on	on	IN
cord-275730-650sjwyy	381	6	STING	sting	NN
cord-275730-650sjwyy	381	7	in	in	IN
cord-275730-650sjwyy	381	8	vivo	vivo	NNP
cord-275730-650sjwyy	381	9	[	[	-LRB-
cord-275730-650sjwyy	381	10	52	52	CD
cord-275730-650sjwyy	381	11	]	]	-RRB-
cord-275730-650sjwyy	381	12	.	.	.
cord-275730-650sjwyy	382	1	Unlike	unlike	IN
cord-275730-650sjwyy	382	2	murine	murine	JJ
cord-275730-650sjwyy	382	3	STING	sting	NN
cord-275730-650sjwyy	382	4	,	,	,
cord-275730-650sjwyy	382	5	the	the	DT
cord-275730-650sjwyy	382	6	human	human	JJ
cord-275730-650sjwyy	382	7	STING	sting	NN
cord-275730-650sjwyy	382	8	gene	gene	NN
cord-275730-650sjwyy	382	9	is	be	VBZ
cord-275730-650sjwyy	382	10	highly	highly	RB
cord-275730-650sjwyy	382	11	heterogeneous	heterogeneous	JJ
cord-275730-650sjwyy	382	12	and	and	CC
cord-275730-650sjwyy	382	13	shows	show	VBZ
cord-275730-650sjwyy	382	14	population	population	NN
cord-275730-650sjwyy	382	15	stratification	stratification	NN
cord-275730-650sjwyy	382	16	[	[	-LRB-
cord-275730-650sjwyy	382	17	51	51	CD
cord-275730-650sjwyy	382	18	,	,	,
cord-275730-650sjwyy	382	19	[	[	-LRB-
cord-275730-650sjwyy	382	20	87	87	CD
cord-275730-650sjwyy	382	21	]	]	-RRB-
cord-275730-650sjwyy	383	1	[	[	-LRB-
cord-275730-650sjwyy	383	2	88	88	CD
cord-275730-650sjwyy	383	3	]	]	-RRB-
cord-275730-650sjwyy	383	4	[	[	-LRB-
cord-275730-650sjwyy	383	5	89	89	CD
cord-275730-650sjwyy	383	6	]	]	-RRB-
cord-275730-650sjwyy	383	7	.	.	.
cord-275730-650sjwyy	384	1	Human	human	JJ
cord-275730-650sjwyy	384	2	STING	sting	NN
cord-275730-650sjwyy	384	3	genes	gene	NNS
cord-275730-650sjwyy	384	4	have	have	VBP
cord-275730-650sjwyy	384	5	five	five	CD
cord-275730-650sjwyy	384	6	alleles	allele	NNS
cord-275730-650sjwyy	384	7	that	that	WDT
cord-275730-650sjwyy	384	8	have	have	VBP
cord-275730-650sjwyy	384	9	a	a	DT
cord-275730-650sjwyy	384	10	population	population	NN
cord-275730-650sjwyy	384	11	frequency	frequency	NN
cord-275730-650sjwyy	384	12	above	above	IN
cord-275730-650sjwyy	384	13	1	1	CD
cord-275730-650sjwyy	384	14	%	%	NN
cord-275730-650sjwyy	384	15	.	.	.
cord-275730-650sjwyy	385	1	They	-PRON-	PRP
cord-275730-650sjwyy	385	2	are	be	VBP
cord-275730-650sjwyy	385	3	R232	r232	FW
cord-275730-650sjwyy	385	4	(	(	-LRB-
cord-275730-650sjwyy	385	5	WT	WT	NNP
cord-275730-650sjwyy	385	6	)	)	-RRB-
cord-275730-650sjwyy	385	7	,	,	,
cord-275730-650sjwyy	385	8	H232	H232	NNP
cord-275730-650sjwyy	385	9	,	,	,
cord-275730-650sjwyy	385	10	HAQ	HAQ	NNP
cord-275730-650sjwyy	385	11	(	(	-LRB-
cord-275730-650sjwyy	385	12	R71H	r71h	NN
cord-275730-650sjwyy	385	13	-	-	HYPH
cord-275730-650sjwyy	385	14	G230A	G230A	NNP
cord-275730-650sjwyy	385	15	-	-	HYPH
cord-275730-650sjwyy	385	16	R293Q	R293Q	NNP
cord-275730-650sjwyy	385	17	)	)	-RRB-
cord-275730-650sjwyy	385	18	,	,	.
cord-275730-650sjwyy	386	1	AQ	AQ	NNP
cord-275730-650sjwyy	386	2	(	(	-LRB-
cord-275730-650sjwyy	386	3	G230A	G230A	NNP
cord-275730-650sjwyy	386	4	-	-	HYPH
cord-275730-650sjwyy	386	5	R293Q	R293Q	NNP
cord-275730-650sjwyy	386	6	)	)	-RRB-
cord-275730-650sjwyy	386	7	,	,	,
cord-275730-650sjwyy	386	8	and	and	CC
cord-275730-650sjwyy	386	9	Q293	Q293	NNP
cord-275730-650sjwyy	386	10	.	.	.
cord-275730-650sjwyy	387	1	The	the	DT
cord-275730-650sjwyy	387	2	HAQ	HAQ	NNP
cord-275730-650sjwyy	387	3	-	-	HYPH
cord-275730-650sjwyy	387	4	STING	STING	NNP
cord-275730-650sjwyy	387	5	is	be	VBZ
cord-275730-650sjwyy	387	6	extremely	extremely	RB
cord-275730-650sjwyy	387	7	popular	popular	JJ
cord-275730-650sjwyy	387	8	in	in	IN
cord-275730-650sjwyy	387	9	East	East	NNP
cord-275730-650sjwyy	387	10	Asians	Asians	NNPS
cord-275730-650sjwyy	387	11	but	but	CC
cord-275730-650sjwyy	387	12	very	very	RB
cord-275730-650sjwyy	387	13	rare	rare	JJ
cord-275730-650sjwyy	387	14	in	in	IN
cord-275730-650sjwyy	387	15	Africans	Africans	NNPS
cord-275730-650sjwyy	387	16	[	[	-LRB-
cord-275730-650sjwyy	387	17	88	88	CD
cord-275730-650sjwyy	387	18	]	]	-RRB-
cord-275730-650sjwyy	387	19	.	.	.
cord-275730-650sjwyy	388	1	In	in	IN
cord-275730-650sjwyy	388	2	contrast	contrast	NN
cord-275730-650sjwyy	388	3	,	,	,
cord-275730-650sjwyy	388	4	AQ	AQ	NNP
cord-275730-650sjwyy	388	5	and	and	CC
cord-275730-650sjwyy	388	6	Q293	Q293	NNP
cord-275730-650sjwyy	388	7	are	be	VBP
cord-275730-650sjwyy	388	8	only	only	RB
cord-275730-650sjwyy	388	9	found	find	VBN
cord-275730-650sjwyy	388	10	in	in	IN
cord-275730-650sjwyy	388	11	Africans	Africans	NNPS
cord-275730-650sjwyy	388	12	[	[	-LRB-
cord-275730-650sjwyy	388	13	51	51	CD
cord-275730-650sjwyy	388	14	]	]	-RRB-
cord-275730-650sjwyy	388	15	.	.	.
cord-275730-650sjwyy	389	1	In	in	IN
cord-275730-650sjwyy	389	2	a	a	DT
cord-275730-650sjwyy	389	3	recent	recent	JJ
cord-275730-650sjwyy	389	4	clinical	clinical	JJ
cord-275730-650sjwyy	389	5	trial	trial	NN
cord-275730-650sjwyy	389	6	,	,	,
cord-275730-650sjwyy	389	7	Sebastian	Sebastian	NNP
cord-275730-650sjwyy	389	8	M.	M.	NNP
cord-275730-650sjwyy	389	9	et	et	NNP
cord-275730-650sjwyy	389	10	al	al	NNP
cord-275730-650sjwyy	389	11	.	.	NNP
cord-275730-650sjwyy	389	12	showed	show	VBD
cord-275730-650sjwyy	389	13	that	that	IN
cord-275730-650sjwyy	389	14	HAQ	HAQ	NNP
cord-275730-650sjwyy	389	15	carriers	carrier	NNS
cord-275730-650sjwyy	389	16	had	have	VBD
cord-275730-650sjwyy	389	17	low	low	JJ
cord-275730-650sjwyy	389	18	anti	anti	JJ
cord-275730-650sjwyy	389	19	-	-	JJ
cord-275730-650sjwyy	389	20	PPS	pps	JJ
cord-275730-650sjwyy	389	21	antibodies	antibody	NNS
cord-275730-650sjwyy	389	22	production	production	NN
cord-275730-650sjwyy	389	23	in	in	IN
cord-275730-650sjwyy	389	24	response	response	NN
cord-275730-650sjwyy	389	25	to	to	IN
cord-275730-650sjwyy	389	26	Pneumovax	Pneumovax	NNP
cord-275730-650sjwyy	389	27	®	®	POS
cord-275730-650sjwyy	389	28	23	23	CD
cord-275730-650sjwyy	389	29	immunization	immunization	NN
cord-275730-650sjwyy	389	30	(	(	-LRB-
cord-275730-650sjwyy	389	31	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-275730-650sjwyy	389	32	:	:	:
cord-275730-650sjwyy	389	33	NCT02471014	NCT02471014	NNP
cord-275730-650sjwyy	389	34	)	)	-RRB-
cord-275730-650sjwyy	389	35	[	[	-LRB-
cord-275730-650sjwyy	389	36	90	90	CD
cord-275730-650sjwyy	389	37	]	]	-RRB-
cord-275730-650sjwyy	389	38	.	.	.
cord-275730-650sjwyy	390	1	The	the	DT
cord-275730-650sjwyy	390	2	result	result	NN
cord-275730-650sjwyy	390	3	is	be	VBZ
cord-275730-650sjwyy	390	4	in	in	IN
cord-275730-650sjwyy	390	5	line	line	NN
cord-275730-650sjwyy	390	6	with	with	IN
cord-275730-650sjwyy	390	7	the	the	DT
cord-275730-650sjwyy	390	8	previous	previous	JJ
cord-275730-650sjwyy	390	9	data	datum	NNS
cord-275730-650sjwyy	390	10	from	from	IN
cord-275730-650sjwyy	390	11	a	a	DT
cord-275730-650sjwyy	390	12	HAQ	HAQ	NNP
cord-275730-650sjwyy	390	13	knock	knock	VB
cord-275730-650sjwyy	390	14	-	-	HYPH
cord-275730-650sjwyy	390	15	in	in	RP
cord-275730-650sjwyy	390	16	mouse	mouse	NN
cord-275730-650sjwyy	390	17	mode	mode	NN
cord-275730-650sjwyy	390	18	[	[	-LRB-
cord-275730-650sjwyy	390	19	51	51	CD
cord-275730-650sjwyy	390	20	]	]	-RRB-
cord-275730-650sjwyy	390	21	.	.	.
cord-275730-650sjwyy	391	1	Lastly	lastly	RB
cord-275730-650sjwyy	391	2	,	,	,
cord-275730-650sjwyy	391	3	Kennedy	Kennedy	NNP
cord-275730-650sjwyy	391	4	R.	R.	NNP
cord-275730-650sjwyy	391	5	B.	B.	NNP
cord-275730-650sjwyy	391	6	et	et	NNP
cord-275730-650sjwyy	391	7	al	al	NNP
cord-275730-650sjwyy	391	8	.	.	NNP
cord-275730-650sjwyy	391	9	demonstrated	demonstrate	VBD
cord-275730-650sjwyy	391	10	that	that	IN
cord-275730-650sjwyy	391	11	PBMC	PBMC	NNP
cord-275730-650sjwyy	391	12	from	from	IN
cord-275730-650sjwyy	391	13	H232	H232	NNP
cord-275730-650sjwyy	391	14	/	/	SYM
cord-275730-650sjwyy	391	15	H232	h232	JJ
cord-275730-650sjwyy	391	16	individuals	individual	NNS
cord-275730-650sjwyy	391	17	had	have	VBD
cord-275730-650sjwyy	391	18	an	an	DT
cord-275730-650sjwyy	391	19	impaired	impaired	JJ
cord-275730-650sjwyy	391	20	STING	sting	NN
cord-275730-650sjwyy	391	21	-	-	HYPH
cord-275730-650sjwyy	391	22	mediated	mediate	VBN
cord-275730-650sjwyy	391	23	innate	innate	JJ
cord-275730-650sjwyy	391	24	immunity	immunity	NN
cord-275730-650sjwyy	391	25	(	(	-LRB-
cord-275730-650sjwyy	391	26	~90	~90	CD
cord-275730-650sjwyy	391	27	%	%	NN
cord-275730-650sjwyy	391	28	decrease	decrease	NN
cord-275730-650sjwyy	391	29	of	of	IN
cord-275730-650sjwyy	391	30	IFNα	IFNα	NNP
cord-275730-650sjwyy	391	31	induction	induction	NN
cord-275730-650sjwyy	391	32	)	)	-RRB-
cord-275730-650sjwyy	391	33	to	to	IN
cord-275730-650sjwyy	391	34	poxviruses	poxvirus	NNS
cord-275730-650sjwyy	391	35	[	[	-LRB-
cord-275730-650sjwyy	391	36	91	91	CD
cord-275730-650sjwyy	391	37	]	]	-RRB-
cord-275730-650sjwyy	391	38	.	.	.
cord-275730-650sjwyy	392	1	A	a	DT
cord-275730-650sjwyy	392	2	large	large	JJ
cord-275730-650sjwyy	392	3	human	human	JJ
cord-275730-650sjwyy	392	4	population	population	NN
cord-275730-650sjwyy	392	5	carries	carry	VBZ
cord-275730-650sjwyy	392	6	these	these	DT
cord-275730-650sjwyy	392	7	STING	sting	NN
cord-275730-650sjwyy	392	8	alleles	allele	NNS
cord-275730-650sjwyy	392	9	[	[	-LRB-
cord-275730-650sjwyy	392	10	51	51	CD
cord-275730-650sjwyy	392	11	]	]	-RRB-
cord-275730-650sjwyy	392	12	.	.	.
cord-275730-650sjwyy	393	1	For	for	IN
cord-275730-650sjwyy	393	2	example	example	NN
cord-275730-650sjwyy	393	3	,	,	,
cord-275730-650sjwyy	393	4	the	the	DT
cord-275730-650sjwyy	393	5	HAQ	HAQ	NNP
cord-275730-650sjwyy	393	6	/	/	SYM
cord-275730-650sjwyy	393	7	HAQ	HAQ	NNP
cord-275730-650sjwyy	393	8	,	,	,
cord-275730-650sjwyy	393	9	HAQ	HAQ	NNP
cord-275730-650sjwyy	393	10	/	/	SYM
cord-275730-650sjwyy	393	11	WT	WT	NNP
cord-275730-650sjwyy	393	12	,	,	,
cord-275730-650sjwyy	393	13	HAQ	HAQ	NNP
cord-275730-650sjwyy	393	14	/	/	SYM
cord-275730-650sjwyy	393	15	H232	H232	NNP
cord-275730-650sjwyy	393	16	,	,	,
cord-275730-650sjwyy	393	17	and	and	CC
cord-275730-650sjwyy	393	18	H232	H232	NNP
cord-275730-650sjwyy	393	19	/	/	SYM
cord-275730-650sjwyy	393	20	H232	h232	JJ
cord-275730-650sjwyy	393	21	humans	human	NNS
cord-275730-650sjwyy	393	22	account	account	VBP
cord-275730-650sjwyy	393	23	for~65	for~65	CD
cord-275730-650sjwyy	393	24	%	%	NN
cord-275730-650sjwyy	393	25	of	of	IN
cord-275730-650sjwyy	393	26	East	East	NNP
cord-275730-650sjwyy	393	27	Asians	Asians	NNPS
cord-275730-650sjwyy	393	28	and~30	and~30	CD
cord-275730-650sjwyy	393	29	%	%	NN
cord-275730-650sjwyy	393	30	of	of	IN
cord-275730-650sjwyy	393	31	Caucasians	Caucasians	NNPS
cord-275730-650sjwyy	393	32	[	[	-LRB-
cord-275730-650sjwyy	393	33	51	51	CD
cord-275730-650sjwyy	393	34	,	,	,
cord-275730-650sjwyy	393	35	92	92	CD
cord-275730-650sjwyy	393	36	]	]	-RRB-
cord-275730-650sjwyy	393	37	.	.	.
cord-275730-650sjwyy	394	1	Thus	thus	RB
cord-275730-650sjwyy	394	2	,	,	,
cord-275730-650sjwyy	394	3	large	large	JJ
cord-275730-650sjwyy	394	4	human	human	JJ
cord-275730-650sjwyy	394	5	populations	population	NNS
cord-275730-650sjwyy	394	6	carry	carry	VBP
cord-275730-650sjwyy	394	7	STING	sting	NN
cord-275730-650sjwyy	394	8	alleles	allele	NNS
cord-275730-650sjwyy	394	9	that	that	WDT
cord-275730-650sjwyy	394	10	impact	impact	VBP
cord-275730-650sjwyy	394	11	CDN	CDN	NNP
cord-275730-650sjwyy	394	12	vaccine	vaccine	NN
cord-275730-650sjwyy	394	13	responses	response	NNS
cord-275730-650sjwyy	394	14	.	.	.
cord-275730-650sjwyy	395	1	The	the	DT
cord-275730-650sjwyy	395	2	median	median	JJ
cord-275730-650sjwyy	395	3	age	age	NN
cord-275730-650sjwyy	395	4	of	of	IN
cord-275730-650sjwyy	395	5	patients	patient	NNS
cord-275730-650sjwyy	395	6	in	in	IN
cord-275730-650sjwyy	395	7	one	one	CD
cord-275730-650sjwyy	395	8	CDN	CDN	NNP
cord-275730-650sjwyy	395	9	clinical	clinical	JJ
cord-275730-650sjwyy	395	10	trial	trial	NN
cord-275730-650sjwyy	395	11	was	be	VBD
cord-275730-650sjwyy	395	12	61	61	CD
cord-275730-650sjwyy	396	1	(	(	-LRB-
cord-275730-650sjwyy	396	2	ClinicalTrials	ClinicalTrials	NNP
cord-275730-650sjwyy	396	3	.	.	.
cord-275730-650sjwyy	397	1	gov	gov	NNP
cord-275730-650sjwyy	397	2	:	:	:
cord-275730-650sjwyy	397	3	NCT02675439	NCT02675439	NNP
cord-275730-650sjwyy	397	4	)	)	-RRB-
cord-275730-650sjwyy	397	5	.	.	.
cord-275730-650sjwyy	398	1	How	how	WRB
cord-275730-650sjwyy	398	2	age	age	NN
cord-275730-650sjwyy	398	3	affects	affect	VBZ
cord-275730-650sjwyy	398	4	CDN	CDN	NNP
cord-275730-650sjwyy	398	5	efficacy	efficacy	NN
cord-275730-650sjwyy	398	6	was	be	VBD
cord-275730-650sjwyy	398	7	not	not	RB
cord-275730-650sjwyy	398	8	well	well	RB
cord-275730-650sjwyy	398	9	-	-	HYPH
cord-275730-650sjwyy	398	10	addressed	address	VBN
cord-275730-650sjwyy	398	11	.	.	.
cord-275730-650sjwyy	399	1	In	in	IN
cord-275730-650sjwyy	399	2	early	early	JJ
cord-275730-650sjwyy	399	3	2019	2019	CD
cord-275730-650sjwyy	399	4	,	,	,
cord-275730-650sjwyy	399	5	Wannemuehler	Wannemuehler	NNP
cord-275730-650sjwyy	399	6	and	and	CC
cord-275730-650sjwyy	399	7	M	M	NNP
cord-275730-650sjwyy	399	8	et	et	NNP
cord-275730-650sjwyy	399	9	al	al	NNP
cord-275730-650sjwyy	399	10	.	.	NNP
cord-275730-650sjwyy	399	11	showed	show	VBD
cord-275730-650sjwyy	399	12	that	that	IN
cord-275730-650sjwyy	399	13	CDN	CDN	NNP
cord-275730-650sjwyy	399	14	induced	induce	VBD
cord-275730-650sjwyy	399	15	serum	serum	NN
cord-275730-650sjwyy	399	16	antibody	antibody	NN
cord-275730-650sjwyy	399	17	production	production	NN
cord-275730-650sjwyy	399	18	in	in	IN
cord-275730-650sjwyy	399	19	20-month	20-month	JJ
cord-275730-650sjwyy	399	20	-	-	HYPH
cord-275730-650sjwyy	399	21	old	old	JJ
cord-275730-650sjwyy	399	22	female	female	JJ
cord-275730-650sjwyy	399	23	BALB	BALB	NNP
cord-275730-650sjwyy	399	24	/	/	SYM
cord-275730-650sjwyy	399	25	c	c	NN
cord-275730-650sjwyy	399	26	mice	mouse	NNS
cord-275730-650sjwyy	399	27	[	[	-LRB-
cord-275730-650sjwyy	399	28	93	93	CD
cord-275730-650sjwyy	399	29	]	]	-RRB-
cord-275730-650sjwyy	399	30	.	.	.
cord-275730-650sjwyy	400	1	They	-PRON-	PRP
cord-275730-650sjwyy	400	2	did	do	VBD
cord-275730-650sjwyy	400	3	not	not	RB
cord-275730-650sjwyy	400	4	examine	examine	VB
cord-275730-650sjwyy	400	5	memory	memory	NN
cord-275730-650sjwyy	400	6	T	t	NN
cord-275730-650sjwyy	400	7	cells	cell	NNS
cord-275730-650sjwyy	400	8	responses	response	NNS
cord-275730-650sjwyy	400	9	or	or	CC
cord-275730-650sjwyy	400	10	distinguish	distinguish	VB
cord-275730-650sjwyy	400	11	high	high	JJ
cord-275730-650sjwyy	400	12	-	-	HYPH
cord-275730-650sjwyy	400	13	and	and	CC
cord-275730-650sjwyy	400	14	low	low	JJ
cord-275730-650sjwyy	400	15	-	-	HYPH
cord-275730-650sjwyy	400	16	affinity	affinity	NN
cord-275730-650sjwyy	400	17	antibodies	antibody	NNS
cord-275730-650sjwyy	400	18	production	production	NN
cord-275730-650sjwyy	400	19	[	[	-LRB-
cord-275730-650sjwyy	400	20	93	93	CD
cord-275730-650sjwyy	400	21	]	]	-RRB-
cord-275730-650sjwyy	400	22	.	.	.
cord-275730-650sjwyy	401	1	They	-PRON-	PRP
cord-275730-650sjwyy	401	2	immunized	immunize	VBD
cord-275730-650sjwyy	401	3	mice	mouse	NNS
cord-275730-650sjwyy	401	4	(	(	-LRB-
cord-275730-650sjwyy	401	5	s.c	s.c	NNP
cord-275730-650sjwyy	401	6	.	.	NNP
cord-275730-650sjwyy	401	7	)	)	-RRB-
cord-275730-650sjwyy	402	1	with	with	IN
cord-275730-650sjwyy	402	2	20	20	CD
cord-275730-650sjwyy	402	3	µg	µg	IN
cord-275730-650sjwyy	402	4	CDN	CDN	NNP
cord-275730-650sjwyy	402	5	[	[	-LRB-
cord-275730-650sjwyy	402	6	93	93	CD
cord-275730-650sjwyy	402	7	]	]	-RRB-
cord-275730-650sjwyy	402	8	,	,	,
cord-275730-650sjwyy	402	9	a	a	DT
cord-275730-650sjwyy	402	10	rather	rather	RB
cord-275730-650sjwyy	402	11	high	high	JJ
cord-275730-650sjwyy	402	12	dose	dose	NN
cord-275730-650sjwyy	402	13	of	of	IN
cord-275730-650sjwyy	402	14	CDN	CDN	NNP
cord-275730-650sjwyy	402	15	for	for	IN
cord-275730-650sjwyy	402	16	mice	mouse	NNS
cord-275730-650sjwyy	402	17	.	.	.
cord-275730-650sjwyy	403	1	In	in	IN
cord-275730-650sjwyy	403	2	late	late	JJ
cord-275730-650sjwyy	403	3	December	December	NNP
cord-275730-650sjwyy	403	4	2019	2019	CD
cord-275730-650sjwyy	403	5	,	,	,
cord-275730-650sjwyy	403	6	Compans	Compans	NNPS
cord-275730-650sjwyy	403	7	and	and	CC
cord-275730-650sjwyy	403	8	R	R	NNP
cord-275730-650sjwyy	403	9	et	et	FW
cord-275730-650sjwyy	403	10	al	al	NNP
cord-275730-650sjwyy	403	11	.	.	NNP
cord-275730-650sjwyy	403	12	showed	show	VBD
cord-275730-650sjwyy	403	13	that	that	IN
cord-275730-650sjwyy	403	14	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	403	15	(	(	-LRB-
cord-275730-650sjwyy	403	16	5	5	CD
cord-275730-650sjwyy	403	17	µg	µg	NN
cord-275730-650sjwyy	403	18	)	)	-RRB-
cord-275730-650sjwyy	403	19	adjuvanted	adjuvante	VBN
cord-275730-650sjwyy	403	20	with	with	IN
cord-275730-650sjwyy	403	21	1	1	CD
cord-275730-650sjwyy	403	22	µg	µg	NN
cord-275730-650sjwyy	403	23	of	of	IN
cord-275730-650sjwyy	403	24	hemagglutinin	hemagglutinin	NN
cord-275730-650sjwyy	403	25	(	(	-LRB-
cord-275730-650sjwyy	403	26	HA	HA	NNP
cord-275730-650sjwyy	403	27	)	)	-RRB-
cord-275730-650sjwyy	403	28	(	(	-LRB-
cord-275730-650sjwyy	403	29	i.d	i.d	NNP
cord-275730-650sjwyy	403	30	.	.	NNP
cord-275730-650sjwyy	403	31	)	)	-RRB-
cord-275730-650sjwyy	404	1	did	do	VBD
cord-275730-650sjwyy	404	2	not	not	RB
cord-275730-650sjwyy	404	3	induce	induce	VB
cord-275730-650sjwyy	404	4	antibodies	antibody	NNS
cord-275730-650sjwyy	404	5	or	or	CC
cord-275730-650sjwyy	404	6	protective	protective	JJ
cord-275730-650sjwyy	404	7	immunity	immunity	NN
cord-275730-650sjwyy	404	8	in	in	IN
cord-275730-650sjwyy	404	9	the	the	DT
cord-275730-650sjwyy	404	10	19-month	19-month	JJ
cord-275730-650sjwyy	404	11	-	-	HYPH
cord-275730-650sjwyy	404	12	old	old	JJ
cord-275730-650sjwyy	404	13	female	female	JJ
cord-275730-650sjwyy	404	14	BALB	BALB	NNP
cord-275730-650sjwyy	404	15	/	/	SYM
cord-275730-650sjwyy	404	16	c	c	NN
cord-275730-650sjwyy	404	17	mice	mouse	NNS
cord-275730-650sjwyy	404	18	[	[	-LRB-
cord-275730-650sjwyy	404	19	94	94	CD
cord-275730-650sjwyy	404	20	]	]	-RRB-
cord-275730-650sjwyy	404	21	.	.	.
cord-275730-650sjwyy	405	1	One	one	CD
cord-275730-650sjwyy	405	2	hundred	hundred	CD
cord-275730-650sjwyy	405	3	percent	percent	NN
cord-275730-650sjwyy	405	4	aged	age	VBN
cord-275730-650sjwyy	405	5	mice	mouse	NNS
cord-275730-650sjwyy	405	6	immunized	immunize	VBN
cord-275730-650sjwyy	405	7	(	(	-LRB-
cord-275730-650sjwyy	405	8	i.d	i.d	NNP
cord-275730-650sjwyy	405	9	.	.	NNP
cord-275730-650sjwyy	405	10	)	)	-RRB-
cord-275730-650sjwyy	406	1	with	with	IN
cord-275730-650sjwyy	406	2	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	406	3	/	/	SYM
cord-275730-650sjwyy	406	4	HA	HA	NNP
cord-275730-650sjwyy	406	5	died	die	VBD
cord-275730-650sjwyy	406	6	subsequently	subsequently	RB
cord-275730-650sjwyy	406	7	from	from	IN
cord-275730-650sjwyy	406	8	the	the	DT
cord-275730-650sjwyy	406	9	influenza	influenza	NN
cord-275730-650sjwyy	406	10	infection	infection	NN
cord-275730-650sjwyy	406	11	[	[	-LRB-
cord-275730-650sjwyy	406	12	94	94	CD
cord-275730-650sjwyy	406	13	]	]	-RRB-
cord-275730-650sjwyy	406	14	.	.	.
cord-275730-650sjwyy	407	1	In	in	IN
cord-275730-650sjwyy	407	2	comparison	comparison	NN
cord-275730-650sjwyy	407	3	,	,	,
cord-275730-650sjwyy	407	4	75	75	CD
cord-275730-650sjwyy	407	5	%	%	NN
cord-275730-650sjwyy	407	6	of	of	IN
cord-275730-650sjwyy	407	7	aged	aged	JJ
cord-275730-650sjwyy	407	8	mice	mouse	NNS
cord-275730-650sjwyy	407	9	immunized	immunize	VBN
cord-275730-650sjwyy	407	10	with	with	IN
cord-275730-650sjwyy	407	11	Quil	Quil	NNP
cord-275730-650sjwyy	407	12	-	-	HYPH
cord-275730-650sjwyy	407	13	A	A	NNP
cord-275730-650sjwyy	407	14	,	,	,
cord-275730-650sjwyy	407	15	a	a	DT
cord-275730-650sjwyy	407	16	saponin	saponin	NN
cord-275730-650sjwyy	407	17	adjuvant	adjuvant	NN
cord-275730-650sjwyy	407	18	,	,	,
cord-275730-650sjwyy	407	19	with	with	IN
cord-275730-650sjwyy	407	20	HA	HA	NNP
cord-275730-650sjwyy	407	21	antigen	antigen	NNP
cord-275730-650sjwyy	407	22	immunization	immunization	NN
cord-275730-650sjwyy	407	23	(	(	-LRB-
cord-275730-650sjwyy	407	24	i.d	i.d	NNP
cord-275730-650sjwyy	407	25	.	.	NNP
cord-275730-650sjwyy	407	26	)	)	-RRB-
cord-275730-650sjwyy	407	27	survived	survive	VBD
cord-275730-650sjwyy	407	28	from	from	IN
cord-275730-650sjwyy	407	29	the	the	DT
cord-275730-650sjwyy	407	30	influenza	influenza	NN
cord-275730-650sjwyy	407	31	infection	infection	NN
cord-275730-650sjwyy	407	32	[	[	-LRB-
cord-275730-650sjwyy	407	33	94	94	CD
cord-275730-650sjwyy	407	34	]	]	-RRB-
cord-275730-650sjwyy	407	35	.	.	.
cord-275730-650sjwyy	408	1	In	in	IN
cord-275730-650sjwyy	408	2	2020	2020	CD
cord-275730-650sjwyy	408	3	,	,	,
cord-275730-650sjwyy	408	4	Gogoi	Gogoi	NNP
cord-275730-650sjwyy	408	5	H	H	NNP
cord-275730-650sjwyy	408	6	et	et	NNP
cord-275730-650sjwyy	408	7	al	al	NNP
cord-275730-650sjwyy	408	8	.	.	NNP
cord-275730-650sjwyy	408	9	reported	report	VBD
cord-275730-650sjwyy	408	10	that	that	IN
cord-275730-650sjwyy	408	11	CDG	CDG	NNP
cord-275730-650sjwyy	408	12	(	(	-LRB-
cord-275730-650sjwyy	408	13	5	5	CD
cord-275730-650sjwyy	408	14	µg	µg	NN
cord-275730-650sjwyy	408	15	,	,	,
cord-275730-650sjwyy	408	16	i.n.)-induced	i.n.)-induced	JJ
cord-275730-650sjwyy	408	17	high	high	JJ
cord-275730-650sjwyy	408	18	-	-	HYPH
cord-275730-650sjwyy	408	19	affinity	affinity	NN
cord-275730-650sjwyy	408	20	,	,	,
cord-275730-650sjwyy	408	21	durable	durable	JJ
cord-275730-650sjwyy	408	22	antibodies	antibody	NNS
cord-275730-650sjwyy	408	23	,	,	,
cord-275730-650sjwyy	408	24	and	and	CC
cord-275730-650sjwyy	408	25	Th1/	th1/	NN
cord-275730-650sjwyy	409	1	Th17	th17	NN
cord-275730-650sjwyy	409	2	responses	response	NNS
cord-275730-650sjwyy	409	3	were	be	VBD
cord-275730-650sjwyy	409	4	severely	severely	RB
cord-275730-650sjwyy	409	5	reduced	reduce	VBN
cord-275730-650sjwyy	409	6	in	in	IN
cord-275730-650sjwyy	409	7	one	one	CD
cord-275730-650sjwyy	409	8	-	-	HYPH
cord-275730-650sjwyy	409	9	year	year	NN
cord-275730-650sjwyy	409	10	-	-	HYPH
cord-275730-650sjwyy	409	11	old	old	JJ
cord-275730-650sjwyy	409	12	(	(	-LRB-
cord-275730-650sjwyy	409	13	~equivalent	~equivalent	CD
cord-275730-650sjwyy	409	14	age	age	NN
cord-275730-650sjwyy	409	15	of	of	IN
cord-275730-650sjwyy	409	16	42.5-year	42.5-year	CD
cord-275730-650sjwyy	409	17	-	-	HYPH
cord-275730-650sjwyy	409	18	old	old	JJ
cord-275730-650sjwyy	409	19	in	in	IN
cord-275730-650sjwyy	409	20	humans	human	NNS
cord-275730-650sjwyy	409	21	)	)	-RRB-
cord-275730-650sjwyy	409	22	and	and	CC
cord-275730-650sjwyy	409	23	two	two	CD
cord-275730-650sjwyy	409	24	-	-	HYPH
cord-275730-650sjwyy	409	25	year	year	NN
cord-275730-650sjwyy	409	26	-	-	HYPH
cord-275730-650sjwyy	409	27	old	old	JJ
cord-275730-650sjwyy	409	28	(	(	-LRB-
cord-275730-650sjwyy	409	29	~equivalent	~equivalent	CD
cord-275730-650sjwyy	409	30	age	age	NN
cord-275730-650sjwyy	409	31	of	of	IN
cord-275730-650sjwyy	409	32	70-year	70-year	JJ
cord-275730-650sjwyy	409	33	-	-	HYPH
cord-275730-650sjwyy	409	34	old	old	JJ
cord-275730-650sjwyy	409	35	in	in	IN
cord-275730-650sjwyy	409	36	humans	human	NNS
cord-275730-650sjwyy	409	37	)	)	-RRB-
cord-275730-650sjwyy	410	1	C57BL/6J	C57BL/6J	NNP
cord-275730-650sjwyy	410	2	mice	mouse	NNS
cord-275730-650sjwyy	410	3	[	[	-LRB-
cord-275730-650sjwyy	410	4	95	95	CD
cord-275730-650sjwyy	410	5	]	]	-RRB-
cord-275730-650sjwyy	410	6	.	.	.
cord-275730-650sjwyy	411	1	Aging	age	VBG
cord-275730-650sjwyy	411	2	decreases	decrease	VBZ
cord-275730-650sjwyy	411	3	the	the	DT
cord-275730-650sjwyy	411	4	response	response	NN
cord-275730-650sjwyy	411	5	to	to	IN
cord-275730-650sjwyy	411	6	vaccination	vaccination	NN
cord-275730-650sjwyy	411	7	[	[	-LRB-
cord-275730-650sjwyy	411	8	96	96	CD
cord-275730-650sjwyy	411	9	]	]	-RRB-
cord-275730-650sjwyy	411	10	[	[	-LRB-
cord-275730-650sjwyy	411	11	97	97	CD
cord-275730-650sjwyy	411	12	]	]	-RRB-
cord-275730-650sjwyy	411	13	[	[	-LRB-
cord-275730-650sjwyy	411	14	98	98	CD
cord-275730-650sjwyy	411	15	]	]	-RRB-
cord-275730-650sjwyy	411	16	[	[	-LRB-
cord-275730-650sjwyy	411	17	99	99	CD
cord-275730-650sjwyy	411	18	]	]	-RRB-
cord-275730-650sjwyy	411	19	.	.	.
cord-275730-650sjwyy	412	1	Thus	thus	RB
cord-275730-650sjwyy	412	2	,	,	,
cord-275730-650sjwyy	412	3	similar	similar	JJ
cord-275730-650sjwyy	412	4	to	to	IN
cord-275730-650sjwyy	412	5	most	most	JJS
cord-275730-650sjwyy	412	6	vaccines	vaccine	NNS
cord-275730-650sjwyy	412	7	,	,	,
cord-275730-650sjwyy	412	8	CDN	CDN	NNP
cord-275730-650sjwyy	412	9	vaccine	vaccine	NN
cord-275730-650sjwyy	412	10	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	412	11	is	be	VBZ
cord-275730-650sjwyy	412	12	also	also	RB
cord-275730-650sjwyy	412	13	negatively	negatively	RB
cord-275730-650sjwyy	412	14	impacted	impact	VBN
cord-275730-650sjwyy	412	15	by	by	IN
cord-275730-650sjwyy	412	16	age	age	NN
cord-275730-650sjwyy	412	17	.	.	.
cord-275730-650sjwyy	413	1	CDN	CDN	NNP
cord-275730-650sjwyy	413	2	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	413	3	induce	induce	VBP
cord-275730-650sjwyy	413	4	balanced	balanced	JJ
cord-275730-650sjwyy	413	5	,	,	,
cord-275730-650sjwyy	413	6	durable	durable	JJ
cord-275730-650sjwyy	413	7	humoral	humoral	JJ
cord-275730-650sjwyy	413	8	,	,	,
cord-275730-650sjwyy	413	9	cellular	cellular	JJ
cord-275730-650sjwyy	413	10	mucosal	mucosal	JJ
cord-275730-650sjwyy	413	11	immune	immune	JJ
cord-275730-650sjwyy	413	12	responses	response	NNS
cord-275730-650sjwyy	413	13	,	,	,
cord-275730-650sjwyy	413	14	and	and	CC
cord-275730-650sjwyy	413	15	potent	potent	JJ
cord-275730-650sjwyy	413	16	anti	anti	JJ
cord-275730-650sjwyy	413	17	-	-	JJ
cord-275730-650sjwyy	413	18	tumor	tumor	JJ
cord-275730-650sjwyy	413	19	immunity	immunity	NN
cord-275730-650sjwyy	413	20	that	that	WDT
cord-275730-650sjwyy	413	21	is	be	VBZ
cord-275730-650sjwyy	413	22	highly	highly	RB
cord-275730-650sjwyy	413	23	desirable	desirable	JJ
cord-275730-650sjwyy	413	24	for	for	IN
cord-275730-650sjwyy	413	25	vaccine	vaccine	NN
cord-275730-650sjwyy	413	26	protection	protection	NN
cord-275730-650sjwyy	413	27	from	from	IN
cord-275730-650sjwyy	413	28	a	a	DT
cord-275730-650sjwyy	413	29	broad	broad	JJ
cord-275730-650sjwyy	413	30	spectrum	spectrum	NN
cord-275730-650sjwyy	413	31	of	of	IN
cord-275730-650sjwyy	413	32	pathogens	pathogen	NNS
cord-275730-650sjwyy	413	33	and	and	CC
cord-275730-650sjwyy	413	34	cancers	cancer	NNS
cord-275730-650sjwyy	413	35	.	.	.
cord-275730-650sjwyy	414	1	STING	sting	NN
cord-275730-650sjwyy	414	2	-	-	HYPH
cord-275730-650sjwyy	414	3	targeting	target	VBG
cord-275730-650sjwyy	414	4	CDNs	cdn	NNS
cord-275730-650sjwyy	414	5	,	,	,
cord-275730-650sjwyy	414	6	thus	thus	RB
cord-275730-650sjwyy	414	7	,	,	,
cord-275730-650sjwyy	414	8	will	will	MD
cord-275730-650sjwyy	414	9	continue	continue	VB
cord-275730-650sjwyy	414	10	to	to	TO
cord-275730-650sjwyy	414	11	garner	garner	VB
cord-275730-650sjwyy	414	12	attention	attention	NN
cord-275730-650sjwyy	414	13	from	from	IN
cord-275730-650sjwyy	414	14	the	the	DT
cord-275730-650sjwyy	414	15	community	community	NN
cord-275730-650sjwyy	414	16	.	.	.
cord-275730-650sjwyy	415	1	To	to	TO
cord-275730-650sjwyy	415	2	advance	advance	VB
cord-275730-650sjwyy	415	3	CDNs	cdn	NNS
cord-275730-650sjwyy	415	4	as	as	IN
cord-275730-650sjwyy	415	5	a	a	DT
cord-275730-650sjwyy	415	6	human	human	JJ
cord-275730-650sjwyy	415	7	vaccine	vaccine	NN
cord-275730-650sjwyy	415	8	and	and	CC
cord-275730-650sjwyy	415	9	cancer	cancer	NN
cord-275730-650sjwyy	415	10	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	415	11	,	,	,
cord-275730-650sjwyy	415	12	more	more	RBR
cord-275730-650sjwyy	415	13	rigorous	rigorous	JJ
cord-275730-650sjwyy	415	14	research	research	NN
cord-275730-650sjwyy	415	15	to	to	TO
cord-275730-650sjwyy	415	16	understand	understand	VB
cord-275730-650sjwyy	415	17	their	-PRON-	PRP$
cord-275730-650sjwyy	415	18	mode	mode	NN
cord-275730-650sjwyy	415	19	of	of	IN
cord-275730-650sjwyy	415	20	action	action	NN
cord-275730-650sjwyy	415	21	in	in	IN
cord-275730-650sjwyy	415	22	vivo	vivo	NN
cord-275730-650sjwyy	415	23	are	be	VBP
cord-275730-650sjwyy	415	24	needed	need	VBN
cord-275730-650sjwyy	415	25	.	.	.
cord-275730-650sjwyy	416	1	For	for	IN
cord-275730-650sjwyy	416	2	example	example	NN
cord-275730-650sjwyy	416	3	,	,	,
cord-275730-650sjwyy	416	4	examine	examine	VB
cord-275730-650sjwyy	416	5	the	the	DT
cord-275730-650sjwyy	416	6	therapeutic	therapeutic	JJ
cord-275730-650sjwyy	416	7	efficacy	efficacy	NN
cord-275730-650sjwyy	416	8	of	of	IN
cord-275730-650sjwyy	416	9	CDNs	CDNs	NNP
cord-275730-650sjwyy	416	10	in	in	IN
cord-275730-650sjwyy	416	11	vivo	vivo	NN
cord-275730-650sjwyy	416	12	using	use	VBG
cord-275730-650sjwyy	416	13	mice	mouse	NNS
cord-275730-650sjwyy	416	14	that	that	WDT
cord-275730-650sjwyy	416	15	have	have	VBP
cord-275730-650sjwyy	416	16	the	the	DT
cord-275730-650sjwyy	416	17	equivalent	equivalent	JJ
cord-275730-650sjwyy	416	18	age	age	NN
cord-275730-650sjwyy	416	19	of	of	IN
cord-275730-650sjwyy	416	20	human	human	JJ
cord-275730-650sjwyy	416	21	cancer	cancer	NN
cord-275730-650sjwyy	416	22	patients	patient	NNS
cord-275730-650sjwyy	416	23	and	and	CC
cord-275730-650sjwyy	416	24	develop	develop	VB
cord-275730-650sjwyy	416	25	CDN	CDN	NNP
cord-275730-650sjwyy	416	26	compositions	composition	NNS
cord-275730-650sjwyy	416	27	that	that	WDT
cord-275730-650sjwyy	416	28	may	may	MD
cord-275730-650sjwyy	416	29	enhance	enhance	VB
cord-275730-650sjwyy	416	30	their	-PRON-	PRP$
cord-275730-650sjwyy	416	31	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	416	32	activities	activity	NNS
cord-275730-650sjwyy	416	33	in	in	IN
cord-275730-650sjwyy	416	34	aged	aged	JJ
cord-275730-650sjwyy	416	35	mice	mouse	NNS
cord-275730-650sjwyy	416	36	.	.	.
cord-275730-650sjwyy	417	1	Accumulating	accumulate	VBG
cord-275730-650sjwyy	417	2	evidence	evidence	NN
cord-275730-650sjwyy	417	3	in	in	IN
cord-275730-650sjwyy	417	4	humans	human	NNS
cord-275730-650sjwyy	417	5	[	[	-LRB-
cord-275730-650sjwyy	417	6	90	90	CD
cord-275730-650sjwyy	417	7	,	,	,
cord-275730-650sjwyy	417	8	91	91	CD
cord-275730-650sjwyy	417	9	,	,	,
cord-275730-650sjwyy	417	10	100	100	CD
cord-275730-650sjwyy	417	11	,	,	,
cord-275730-650sjwyy	417	12	101	101	CD
cord-275730-650sjwyy	417	13	]	]	-RRB-
cord-275730-650sjwyy	417	14	and	and	CC
cord-275730-650sjwyy	417	15	mouse	mouse	NN
cord-275730-650sjwyy	417	16	models	model	NNS
cord-275730-650sjwyy	417	17	[	[	-LRB-
cord-275730-650sjwyy	417	18	50	50	CD
cord-275730-650sjwyy	417	19	,	,	,
cord-275730-650sjwyy	417	20	51	51	CD
cord-275730-650sjwyy	417	21	,	,	,
cord-275730-650sjwyy	417	22	102	102	CD
cord-275730-650sjwyy	417	23	]	]	-RRB-
cord-275730-650sjwyy	417	24	indicated	indicate	VBD
cord-275730-650sjwyy	417	25	that	that	IN
cord-275730-650sjwyy	417	26	the	the	DT
cord-275730-650sjwyy	417	27	HAQ	HAQ	NNP
cord-275730-650sjwyy	417	28	and	and	CC
cord-275730-650sjwyy	417	29	H232	H232	NNP
cord-275730-650sjwyy	417	30	alleles	allele	NNS
cord-275730-650sjwyy	417	31	are	be	VBP
cord-275730-650sjwyy	417	32	impaired	impair	VBN
cord-275730-650sjwyy	417	33	in	in	IN
cord-275730-650sjwyy	417	34	the	the	DT
cord-275730-650sjwyy	417	35	STING	sting	NN
cord-275730-650sjwyy	417	36	function	function	NN
cord-275730-650sjwyy	417	37	.	.	.
cord-275730-650sjwyy	418	1	CDN	CDN	NNP
cord-275730-650sjwyy	418	2	-	-	HYPH
cord-275730-650sjwyy	418	3	adjuvanted	adjuvante	VBN
cord-275730-650sjwyy	418	4	vaccines	vaccine	NNS
cord-275730-650sjwyy	418	5	aim	aim	VBP
cord-275730-650sjwyy	418	6	to	to	TO
cord-275730-650sjwyy	418	7	protect	protect	VB
cord-275730-650sjwyy	418	8	the	the	DT
cord-275730-650sjwyy	418	9	general	general	JJ
cord-275730-650sjwyy	418	10	public	public	NN
cord-275730-650sjwyy	418	11	from	from	IN
cord-275730-650sjwyy	418	12	the	the	DT
cord-275730-650sjwyy	418	13	pandemic	pandemic	NN
cord-275730-650sjwyy	418	14	and	and	CC
cord-275730-650sjwyy	418	15	endemic	endemic	JJ
cord-275730-650sjwyy	418	16	.	.	.
cord-275730-650sjwyy	419	1	CDN	CDN	NNP
cord-275730-650sjwyy	419	2	derivatives	derivative	NNS
cord-275730-650sjwyy	419	3	that	that	WDT
cord-275730-650sjwyy	419	4	activate	activate	VBP
cord-275730-650sjwyy	419	5	HAQ	HAQ	NNP
cord-275730-650sjwyy	419	6	and	and	CC
cord-275730-650sjwyy	419	7	H232	H232	NNP
cord-275730-650sjwyy	419	8	STING	sting	VB
cord-275730-650sjwyy	419	9	in	in	IN
cord-275730-650sjwyy	419	10	vivo	vivo	NN
cord-275730-650sjwyy	419	11	are	be	VBP
cord-275730-650sjwyy	419	12	highly	highly	RB
cord-275730-650sjwyy	419	13	desirable	desirable	JJ
cord-275730-650sjwyy	419	14	.	.	.
cord-275730-650sjwyy	420	1	Notably	notably	RB
cord-275730-650sjwyy	420	2	,	,	,
cord-275730-650sjwyy	420	3	the	the	DT
cord-275730-650sjwyy	420	4	NOD	NOD	NNP
cord-275730-650sjwyy	420	5	mice	mouse	NNS
cord-275730-650sjwyy	420	6	,	,	,
cord-275730-650sjwyy	420	7	which	which	WDT
cord-275730-650sjwyy	420	8	contain	contain	VBP
cord-275730-650sjwyy	420	9	an	an	DT
cord-275730-650sjwyy	420	10	N210D	n210d	NN
cord-275730-650sjwyy	420	11	of	of	IN
cord-275730-650sjwyy	420	12	STING	sting	NN
cord-275730-650sjwyy	420	13	[	[	-LRB-
cord-275730-650sjwyy	420	14	47	47	CD
cord-275730-650sjwyy	420	15	]	]	-RRB-
cord-275730-650sjwyy	420	16	,	,	,
cord-275730-650sjwyy	420	17	and	and	CC
cord-275730-650sjwyy	420	18	the	the	DT
cord-275730-650sjwyy	420	19	R231H	R231H	NNP
cord-275730-650sjwyy	420	20	mouse	mouse	NN
cord-275730-650sjwyy	420	21	[	[	-LRB-
cord-275730-650sjwyy	420	22	50	50	CD
cord-275730-650sjwyy	420	23	]	]	-RRB-
cord-275730-650sjwyy	420	24	react	react	VBP
cord-275730-650sjwyy	420	25	to	to	IN
cord-275730-650sjwyy	420	26	cGAMP	cGAMP	NNP
cord-275730-650sjwyy	421	1	but	but	CC
cord-275730-650sjwyy	421	2	not	not	RB
cord-275730-650sjwyy	421	3	CDG	CDG	NNP
cord-275730-650sjwyy	421	4	for	for	IN
cord-275730-650sjwyy	421	5	type	type	NN
cord-275730-650sjwyy	421	6	I	-PRON-	PRP
cord-275730-650sjwyy	421	7	IFNs	ifns	VBP
cord-275730-650sjwyy	421	8	production	production	NN
cord-275730-650sjwyy	421	9	.	.	.
cord-275730-650sjwyy	422	1	Thus	thus	RB
cord-275730-650sjwyy	422	2	,	,	,
cord-275730-650sjwyy	422	3	it	-PRON-	PRP
cord-275730-650sjwyy	422	4	is	be	VBZ
cord-275730-650sjwyy	422	5	possible	possible	JJ
cord-275730-650sjwyy	422	6	to	to	TO
cord-275730-650sjwyy	422	7	design	design	VB
cord-275730-650sjwyy	422	8	a	a	DT
cord-275730-650sjwyy	422	9	CDN	CDN	NNP
cord-275730-650sjwyy	422	10	that	that	WDT
cord-275730-650sjwyy	422	11	activates	activate	VBZ
cord-275730-650sjwyy	422	12	H232	h232	JJ
cord-275730-650sjwyy	422	13	or	or	CC
cord-275730-650sjwyy	422	14	even	even	RB
cord-275730-650sjwyy	422	15	HAQ	HAQ	NNP
cord-275730-650sjwyy	422	16	STING	STING	NNP
cord-275730-650sjwyy	422	17	in	in	IN
cord-275730-650sjwyy	422	18	vivo	vivo	NN
cord-275730-650sjwyy	422	19	.	.	.
cord-275730-650sjwyy	423	1	Alternatively	alternatively	RB
cord-275730-650sjwyy	423	2	,	,	,
cord-275730-650sjwyy	423	3	He	-PRON-	PRP
cord-275730-650sjwyy	423	4	Y.	Y.	NNP
cord-275730-650sjwyy	423	5	et	et	NNP
cord-275730-650sjwyy	423	6	al	al	NNP
cord-275730-650sjwyy	423	7	.	.	.
cord-275730-650sjwyy	424	1	recently	recently	RB
cord-275730-650sjwyy	424	2	developed	develop	VBD
cord-275730-650sjwyy	424	3	a	a	DT
cord-275730-650sjwyy	424	4	cGAMP	cgamp	JJ
cord-275730-650sjwyy	424	5	-	-	HYPH
cord-275730-650sjwyy	424	6	STING∆TM	sting∆tm	NN
cord-275730-650sjwyy	424	7	tetramer	tetramer	NN
cord-275730-650sjwyy	424	8	that	that	WDT
cord-275730-650sjwyy	424	9	showed	show	VBD
cord-275730-650sjwyy	424	10	promising	promise	VBG
cord-275730-650sjwyy	424	11	anti	anti	JJ
cord-275730-650sjwyy	424	12	-	-	JJ
cord-275730-650sjwyy	424	13	tumor	tumor	JJ
cord-275730-650sjwyy	424	14	activity	activity	NN
cord-275730-650sjwyy	424	15	in	in	IN
cord-275730-650sjwyy	424	16	vivo	vivo	NN
cord-275730-650sjwyy	424	17	and	and	CC
cord-275730-650sjwyy	424	18	activates	activate	VBZ
cord-275730-650sjwyy	424	19	type	type	NN
cord-275730-650sjwyy	424	20	I	-PRON-	PRP
cord-275730-650sjwyy	424	21	IFNs	ifns	VBP
cord-275730-650sjwyy	424	22	in	in	IN
cord-275730-650sjwyy	424	23	the	the	DT
cord-275730-650sjwyy	424	24	absence	absence	NN
cord-275730-650sjwyy	424	25	of	of	IN
cord-275730-650sjwyy	424	26	STING	sting	NN
cord-275730-650sjwyy	424	27	gene	gene	NN
cord-275730-650sjwyy	424	28	[	[	-LRB-
cord-275730-650sjwyy	424	29	103	103	CD
cord-275730-650sjwyy	424	30	]	]	-RRB-
cord-275730-650sjwyy	424	31	.	.	.
cord-275730-650sjwyy	425	1	Meanwhile	meanwhile	RB
cord-275730-650sjwyy	425	2	,	,	,
cord-275730-650sjwyy	425	3	for	for	IN
cord-275730-650sjwyy	425	4	CDNs	cdn	NNS
cord-275730-650sjwyy	425	5	that	that	WDT
cord-275730-650sjwyy	425	6	already	already	RB
cord-275730-650sjwyy	425	7	entered	enter	VBD
cord-275730-650sjwyy	425	8	clinical	clinical	JJ
cord-275730-650sjwyy	425	9	trials	trial	NNS
cord-275730-650sjwyy	425	10	,	,	,
cord-275730-650sjwyy	425	11	it	-PRON-	PRP
cord-275730-650sjwyy	425	12	is	be	VBZ
cord-275730-650sjwyy	425	13	worth	worth	JJ
cord-275730-650sjwyy	425	14	adopting	adopt	VBG
cord-275730-650sjwyy	425	15	the	the	DT
cord-275730-650sjwyy	425	16	personalized	personalized	JJ
cord-275730-650sjwyy	425	17	medicine	medicine	NN
cord-275730-650sjwyy	425	18	concept	concept	NN
cord-275730-650sjwyy	425	19	and	and	CC
cord-275730-650sjwyy	425	20	analyzing	analyze	VBG
cord-275730-650sjwyy	425	21	the	the	DT
cord-275730-650sjwyy	425	22	data	datum	NNS
cord-275730-650sjwyy	425	23	based	base	VBN
cord-275730-650sjwyy	425	24	on	on	IN
cord-275730-650sjwyy	425	25	STING	sting	NN
cord-275730-650sjwyy	425	26	genotypes	genotype	NNS
cord-275730-650sjwyy	425	27	or	or	CC
cord-275730-650sjwyy	425	28	designing	design	VBG
cord-275730-650sjwyy	425	29	the	the	DT
cord-275730-650sjwyy	425	30	study	study	NN
cord-275730-650sjwyy	425	31	based	base	VBN
cord-275730-650sjwyy	425	32	on	on	IN
cord-275730-650sjwyy	425	33	the	the	DT
cord-275730-650sjwyy	425	34	patients	patient	NNS
cord-275730-650sjwyy	425	35	'	'	POS
cord-275730-650sjwyy	425	36	STING	sting	NN
cord-275730-650sjwyy	425	37	genotypes	genotype	NNS
cord-275730-650sjwyy	425	38	and	and	CC
cord-275730-650sjwyy	425	39	age	age	NN
cord-275730-650sjwyy	425	40	.	.	.
cord-275730-650sjwyy	426	1	The	the	DT
cord-275730-650sjwyy	426	2	majority	majority	NN
cord-275730-650sjwyy	426	3	of	of	IN
cord-275730-650sjwyy	426	4	the	the	DT
cord-275730-650sjwyy	426	5	human	human	JJ
cord-275730-650sjwyy	426	6	population	population	NN
cord-275730-650sjwyy	426	7	(	(	-LRB-
cord-275730-650sjwyy	426	8	R232	R232	NNP
cord-275730-650sjwyy	426	9	/	/	SYM
cord-275730-650sjwyy	426	10	R232	r232	LS
cord-275730-650sjwyy	426	11	)	)	-RRB-
cord-275730-650sjwyy	426	12	will	will	MD
cord-275730-650sjwyy	426	13	get	get	VB
cord-275730-650sjwyy	426	14	the	the	DT
cord-275730-650sjwyy	426	15	immediate	immediate	JJ
cord-275730-650sjwyy	426	16	benefit	benefit	NN
cord-275730-650sjwyy	426	17	of	of	IN
cord-275730-650sjwyy	426	18	the	the	DT
cord-275730-650sjwyy	426	19	superior	superior	JJ
cord-275730-650sjwyy	426	20	and	and	CC
cord-275730-650sjwyy	426	21	unparalleled	unparalleled	JJ
cord-275730-650sjwyy	426	22	vaccine	vaccine	NN
cord-275730-650sjwyy	426	23	adjuvant	adjuvant	NN
cord-275730-650sjwyy	426	24	and	and	CC
cord-275730-650sjwyy	426	25	anti	anti	JJ
cord-275730-650sjwyy	426	26	-	-	JJ
cord-275730-650sjwyy	426	27	tumor	tumor	JJ
cord-275730-650sjwyy	426	28	activity	activity	NN
cord-275730-650sjwyy	426	29	of	of	IN
cord-275730-650sjwyy	426	30	CDNs	cdn	NNS
cord-275730-650sjwyy	426	31	.	.	.
cord-275730-650sjwyy	427	1	Towards	towards	IN
cord-275730-650sjwyy	427	2	an	an	DT
cord-275730-650sjwyy	427	3	understanding	understanding	NN
cord-275730-650sjwyy	427	4	of	of	IN
cord-275730-650sjwyy	427	5	the	the	DT
cord-275730-650sjwyy	427	6	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	427	7	action	action	NN
cord-275730-650sjwyy	427	8	of	of	IN
cord-275730-650sjwyy	427	9	aluminium	aluminium	NN
cord-275730-650sjwyy	427	10	Systems	Systems	NNP
cord-275730-650sjwyy	427	11	analysis	analysis	NN
cord-275730-650sjwyy	427	12	of	of	IN
cord-275730-650sjwyy	427	13	human	human	JJ
cord-275730-650sjwyy	427	14	vaccine	vaccine	NN
cord-275730-650sjwyy	427	15	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	427	16	Correlates	correlate	VBZ
cord-275730-650sjwyy	427	17	of	of	IN
cord-275730-650sjwyy	427	18	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	427	19	:	:	:
cord-275730-650sjwyy	427	20	A	a	DT
cord-275730-650sjwyy	427	21	review	review	NN
cord-275730-650sjwyy	427	22	on	on	IN
cord-275730-650sjwyy	427	23	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	427	24	in	in	IN
cord-275730-650sjwyy	427	25	licensed	licensed	JJ
cord-275730-650sjwyy	427	26	vaccines	vaccine	NNS
cord-275730-650sjwyy	427	27	C	c	NN
cord-275730-650sjwyy	427	28	-	-	HYPH
cord-275730-650sjwyy	427	29	di	di	NNP
cord-275730-650sjwyy	427	30	-	-	HYPH
cord-275730-650sjwyy	427	31	gmp	gmp	NNP
cord-275730-650sjwyy	427	32	is	be	VBZ
cord-275730-650sjwyy	427	33	an	an	DT
cord-275730-650sjwyy	427	34	effective	effective	JJ
cord-275730-650sjwyy	427	35	immunomodulator	immunomodulator	NN
cord-275730-650sjwyy	427	36	and	and	CC
cord-275730-650sjwyy	427	37	vaccine	vaccine	NN
cord-275730-650sjwyy	427	38	adjuvant	adjuvant	NN
cord-275730-650sjwyy	427	39	against	against	IN
cord-275730-650sjwyy	427	40	pneumococcal	pneumococcal	JJ
cord-275730-650sjwyy	427	41	infection	infection	NN
cord-275730-650sjwyy	427	42	3',5'-cyclic	3',5'-cyclic	CD
cord-275730-650sjwyy	427	43	diguanylic	diguanylic	JJ
cord-275730-650sjwyy	427	44	acid	acid	NN
cord-275730-650sjwyy	427	45	elicits	elicit	VBZ
cord-275730-650sjwyy	427	46	mucosal	mucosal	JJ
cord-275730-650sjwyy	427	47	immunity	immunity	NN
cord-275730-650sjwyy	427	48	against	against	IN
cord-275730-650sjwyy	427	49	bacterial	bacterial	JJ
cord-275730-650sjwyy	427	50	infection	infection	NN
cord-275730-650sjwyy	427	51	Evidence	evidence	NN
cord-275730-650sjwyy	427	52	for	for	IN
cord-275730-650sjwyy	427	53	cyclic	cyclic	JJ
cord-275730-650sjwyy	427	54	diguanylate	diguanylate	NN
cord-275730-650sjwyy	427	55	as	as	IN
cord-275730-650sjwyy	427	56	a	a	DT
cord-275730-650sjwyy	427	57	vaccine	vaccine	NN
cord-275730-650sjwyy	427	58	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	427	59	with	with	IN
cord-275730-650sjwyy	427	60	novel	novel	JJ
cord-275730-650sjwyy	427	61	immunostimulatory	immunostimulatory	NNP
cord-275730-650sjwyy	427	62	activities	activity	NNS
cord-275730-650sjwyy	428	1	Bis-(3',5')-cyclic	Bis-(3',5')-cyclic	NNP
cord-275730-650sjwyy	428	2	dimeric	dimeric	JJ
cord-275730-650sjwyy	428	3	adenosine	adenosine	NN
cord-275730-650sjwyy	428	4	monophosphate	monophosphate	NN
cord-275730-650sjwyy	428	5	:	:	:
cord-275730-650sjwyy	429	1	Strong	strong	JJ
cord-275730-650sjwyy	429	2	th1	th1	NNP
cord-275730-650sjwyy	429	3	/	/	,
cord-275730-650sjwyy	429	4	th2/	th2/	NN
cord-275730-650sjwyy	430	1	th17	th17	NNP
cord-275730-650sjwyy	431	1	promoting	promote	VBG
cord-275730-650sjwyy	431	2	mucosal	mucosal	JJ
cord-275730-650sjwyy	431	3	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	432	1	Intranasal	Intranasal	NNP
cord-275730-650sjwyy	432	2	c	c	NNP
cord-275730-650sjwyy	432	3	-	-	HYPH
cord-275730-650sjwyy	432	4	di	di	NNP
cord-275730-650sjwyy	432	5	-	-	HYPH
cord-275730-650sjwyy	432	6	gmp	gmp	NNP
cord-275730-650sjwyy	432	7	-	-	HYPH
cord-275730-650sjwyy	432	8	adjuvanted	adjuvante	VBN
cord-275730-650sjwyy	432	9	plant	plant	NN
cord-275730-650sjwyy	432	10	-	-	HYPH
cord-275730-650sjwyy	432	11	derived	derive	VBN
cord-275730-650sjwyy	432	12	h5	h5	NNP
cord-275730-650sjwyy	432	13	influenza	influenza	NN
cord-275730-650sjwyy	432	14	vaccine	vaccine	NN
cord-275730-650sjwyy	432	15	induces	induce	VBZ
cord-275730-650sjwyy	432	16	multifunctional	multifunctional	JJ
cord-275730-650sjwyy	432	17	th1	th1	NNP
cord-275730-650sjwyy	432	18	cd4	cd4	NNP
cord-275730-650sjwyy	432	19	+	+	CC
cord-275730-650sjwyy	432	20	cells	cell	NNS
cord-275730-650sjwyy	432	21	and	and	CC
cord-275730-650sjwyy	432	22	strong	strong	JJ
cord-275730-650sjwyy	432	23	mucosal	mucosal	JJ
cord-275730-650sjwyy	432	24	and	and	CC
cord-275730-650sjwyy	432	25	systemic	systemic	JJ
cord-275730-650sjwyy	432	26	antibody	antibody	NN
cord-275730-650sjwyy	432	27	responses	response	NNS
cord-275730-650sjwyy	432	28	in	in	IN
cord-275730-650sjwyy	432	29	mice	mouse	NNS
cord-275730-650sjwyy	433	1	The	the	DT
cord-275730-650sjwyy	433	2	bacterial	bacterial	JJ
cord-275730-650sjwyy	433	3	second	second	JJ
cord-275730-650sjwyy	433	4	messenger	messenger	NN
cord-275730-650sjwyy	433	5	cyclic	cyclic	JJ
cord-275730-650sjwyy	433	6	digmp	digmp	NNP
cord-275730-650sjwyy	433	7	exhibits	exhibit	VBZ
cord-275730-650sjwyy	433	8	potent	potent	JJ
cord-275730-650sjwyy	433	9	adjuvant	adjuvant	NN
cord-275730-650sjwyy	433	10	properties	property	NNS
cord-275730-650sjwyy	434	1	Pulmonary	pulmonary	JJ
cord-275730-650sjwyy	434	2	surfactant	surfactant	NN
cord-275730-650sjwyy	434	3	-	-	HYPH
cord-275730-650sjwyy	434	4	biomimetic	biomimetic	JJ
cord-275730-650sjwyy	434	5	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	434	6	potentiate	potentiate	VBP
cord-275730-650sjwyy	434	7	heterosubtypic	heterosubtypic	JJ
cord-275730-650sjwyy	434	8	influenza	influenza	NN
cord-275730-650sjwyy	434	9	immunity	immunity	NN
cord-275730-650sjwyy	434	10	Sting	Sting	NNP
cord-275730-650sjwyy	434	11	-	-	HYPH
cord-275730-650sjwyy	434	12	activating	activate	VBG
cord-275730-650sjwyy	434	13	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	434	14	elicit	elicit	VBP
cord-275730-650sjwyy	434	15	a	a	DT
cord-275730-650sjwyy	434	16	th17	th17	NN
cord-275730-650sjwyy	434	17	immune	immune	JJ
cord-275730-650sjwyy	434	18	response	response	NN
cord-275730-650sjwyy	434	19	and	and	CC
cord-275730-650sjwyy	434	20	protect	protect	VB
cord-275730-650sjwyy	434	21	against	against	IN
cord-275730-650sjwyy	434	22	mycobacterium	mycobacterium	NN
cord-275730-650sjwyy	434	23	tuberculosis	tuberculosis	NN
cord-275730-650sjwyy	434	24	infection	infection	NN
cord-275730-650sjwyy	434	25	Sublingual	sublingual	NN
cord-275730-650sjwyy	434	26	targeting	targeting	NN
cord-275730-650sjwyy	434	27	of	of	IN
cord-275730-650sjwyy	434	28	sting	sting	NN
cord-275730-650sjwyy	434	29	with	with	IN
cord-275730-650sjwyy	434	30	3'3'-cgamp	3'3'-cgamp	NN
cord-275730-650sjwyy	434	31	promotes	promote	VBZ
cord-275730-650sjwyy	434	32	systemic	systemic	JJ
cord-275730-650sjwyy	434	33	and	and	CC
cord-275730-650sjwyy	434	34	mucosal	mucosal	JJ
cord-275730-650sjwyy	434	35	immunity	immunity	NN
cord-275730-650sjwyy	434	36	against	against	IN
cord-275730-650sjwyy	434	37	anthrax	anthrax	NN
cord-275730-650sjwyy	434	38	toxins	toxin	NNS
cord-275730-650sjwyy	435	1	Cyclic	Cyclic	NNP
cord-275730-650sjwyy	435	2	di	di	NNP
cord-275730-650sjwyy	435	3	-	-	HYPH
cord-275730-650sjwyy	435	4	gmp	gmp	NNP
cord-275730-650sjwyy	435	5	stimulates	stimulate	VBZ
cord-275730-650sjwyy	435	6	protective	protective	JJ
cord-275730-650sjwyy	435	7	innate	innate	JJ
cord-275730-650sjwyy	435	8	immunity	immunity	NN
cord-275730-650sjwyy	435	9	in	in	IN
cord-275730-650sjwyy	435	10	bacterial	bacterial	JJ
cord-275730-650sjwyy	435	11	pneumonia	pneumonia	NN
cord-275730-650sjwyy	435	12	C	C	NNP
cord-275730-650sjwyy	435	13	-	-	HYPH
cord-275730-650sjwyy	435	14	di	di	NNP
cord-275730-650sjwyy	435	15	-	-	HYPH
cord-275730-650sjwyy	435	16	gmp	gmp	NNP
cord-275730-650sjwyy	435	17	protects	protect	VBZ
cord-275730-650sjwyy	435	18	against	against	IN
cord-275730-650sjwyy	435	19	intranasal	intranasal	NNP
cord-275730-650sjwyy	435	20	acinetobacter	acinetobacter	NNP
cord-275730-650sjwyy	435	21	baumannii	baumannii	NNP
cord-275730-650sjwyy	435	22	infection	infection	NN
cord-275730-650sjwyy	435	23	in	in	IN
cord-275730-650sjwyy	435	24	mice	mouse	NNS
cord-275730-650sjwyy	435	25	by	by	IN
cord-275730-650sjwyy	435	26	chemokine	chemokine	NN
cord-275730-650sjwyy	435	27	induction	induction	NN
cord-275730-650sjwyy	435	28	and	and	CC
cord-275730-650sjwyy	435	29	enhanced	enhanced	JJ
cord-275730-650sjwyy	435	30	neutrophil	neutrophil	NN
cord-275730-650sjwyy	435	31	recruitment	recruitment	NN
cord-275730-650sjwyy	435	32	C	c	NN
cord-275730-650sjwyy	435	33	-	-	HYPH
cord-275730-650sjwyy	435	34	di	di	NNP
cord-275730-650sjwyy	435	35	-	-	HYPH
cord-275730-650sjwyy	435	36	gmp	gmp	NNP
cord-275730-650sjwyy	435	37	as	as	IN
cord-275730-650sjwyy	435	38	a	a	DT
cord-275730-650sjwyy	435	39	vaccine	vaccine	NN
cord-275730-650sjwyy	435	40	adjuvant	adjuvant	NN
cord-275730-650sjwyy	435	41	enhances	enhance	VBZ
cord-275730-650sjwyy	435	42	protection	protection	NN
cord-275730-650sjwyy	435	43	against	against	IN
cord-275730-650sjwyy	435	44	systemic	systemic	JJ
cord-275730-650sjwyy	435	45	methicillin	methicillin	NN
cord-275730-650sjwyy	435	46	-	-	HYPH
cord-275730-650sjwyy	435	47	resistant	resistant	JJ
cord-275730-650sjwyy	435	48	staphylococcus	staphylococcus	NN
cord-275730-650sjwyy	435	49	aureus	aureus	NN
cord-275730-650sjwyy	435	50	(	(	-LRB-
cord-275730-650sjwyy	435	51	mrsa	mrsa	NNP
cord-275730-650sjwyy	435	52	)	)	-RRB-
cord-275730-650sjwyy	435	53	infection	infection	NN
cord-275730-650sjwyy	435	54	.	.	.
cord-275730-650sjwyy	436	1	Vaccine	Vaccine	NNP
cord-275730-650sjwyy	436	2	Direct	direct	JJ
cord-275730-650sjwyy	436	3	activation	activation	NN
cord-275730-650sjwyy	436	4	of	of	IN
cord-275730-650sjwyy	436	5	sting	sting	NN
cord-275730-650sjwyy	436	6	in	in	IN
cord-275730-650sjwyy	436	7	the	the	DT
cord-275730-650sjwyy	436	8	tumor	tumor	NN
cord-275730-650sjwyy	436	9	microenvironment	microenvironment	NN
cord-275730-650sjwyy	436	10	leads	lead	VBZ
cord-275730-650sjwyy	436	11	to	to	IN
cord-275730-650sjwyy	436	12	potent	potent	JJ
cord-275730-650sjwyy	436	13	and	and	CC
cord-275730-650sjwyy	436	14	systemic	systemic	JJ
cord-275730-650sjwyy	436	15	tumor	tumor	NN
cord-275730-650sjwyy	436	16	regression	regression	NN
cord-275730-650sjwyy	436	17	and	and	CC
cord-275730-650sjwyy	436	18	immunity	immunity	NN
cord-275730-650sjwyy	436	19	Sting	Sting	NNP
cord-275730-650sjwyy	436	20	agonist	agonist	NN
cord-275730-650sjwyy	436	21	formulated	formulate	VBD
cord-275730-650sjwyy	436	22	cancer	cancer	NN
cord-275730-650sjwyy	436	23	vaccines	vaccine	NNS
cord-275730-650sjwyy	436	24	can	can	MD
cord-275730-650sjwyy	436	25	cure	cure	VB
cord-275730-650sjwyy	436	26	established	establish	VBN
cord-275730-650sjwyy	436	27	tumors	tumor	NNS
cord-275730-650sjwyy	436	28	resistant	resistant	JJ
cord-275730-650sjwyy	436	29	to	to	IN
cord-275730-650sjwyy	436	30	pd-1	pd-1	NNP
cord-275730-650sjwyy	436	31	blockade	blockade	NN
cord-275730-650sjwyy	437	1	The	the	DT
cord-275730-650sjwyy	437	2	sting	sting	NN
cord-275730-650sjwyy	437	3	activator	activator	NN
cord-275730-650sjwyy	437	4	c	c	NNP
cord-275730-650sjwyy	437	5	-	-	HYPH
cord-275730-650sjwyy	437	6	di	di	FW
cord-275730-650sjwyy	437	7	-	-	HYPH
cord-275730-650sjwyy	437	8	amp	amp	NN
cord-275730-650sjwyy	437	9	exerts	exert	VBZ
cord-275730-650sjwyy	437	10	superior	superior	JJ
cord-275730-650sjwyy	437	11	adjuvant	adjuvant	NN
cord-275730-650sjwyy	437	12	properties	property	NNS
cord-275730-650sjwyy	437	13	than	than	IN
cord-275730-650sjwyy	437	14	the	the	DT
cord-275730-650sjwyy	437	15	formulation	formulation	NN
cord-275730-650sjwyy	438	1	poly(i	poly(i	NNS
cord-275730-650sjwyy	438	2	:	:	:
cord-275730-650sjwyy	438	3	C)/cpg	C)/cpg	NNP
cord-275730-650sjwyy	438	4	after	after	IN
cord-275730-650sjwyy	438	5	subcutaneous	subcutaneous	JJ
cord-275730-650sjwyy	438	6	vaccination	vaccination	NN
cord-275730-650sjwyy	438	7	with	with	IN
cord-275730-650sjwyy	438	8	soluble	soluble	JJ
cord-275730-650sjwyy	438	9	protein	protein	NN
cord-275730-650sjwyy	438	10	antigen	antigen	NN
cord-275730-650sjwyy	438	11	or	or	CC
cord-275730-650sjwyy	438	12	dec-205-mediated	dec-205-mediated	JJ
cord-275730-650sjwyy	438	13	antigen	antigen	NN
cord-275730-650sjwyy	438	14	targeting	target	VBG
cord-275730-650sjwyy	438	15	to	to	IN
cord-275730-650sjwyy	438	16	dendritic	dendritic	JJ
cord-275730-650sjwyy	438	17	cells	cell	NNS
cord-275730-650sjwyy	439	1	The	the	DT
cord-275730-650sjwyy	439	2	member	member	NN
cord-275730-650sjwyy	439	3	of	of	IN
cord-275730-650sjwyy	439	4	the	the	DT
cord-275730-650sjwyy	439	5	cyclic	cyclic	JJ
cord-275730-650sjwyy	439	6	di	di	NN
cord-275730-650sjwyy	439	7	-	-	HYPH
cord-275730-650sjwyy	439	8	nucleotide	nucleotide	JJ
cord-275730-650sjwyy	439	9	family	family	NN
cord-275730-650sjwyy	439	10	bis-(3	bis-(3	NNP
cord-275730-650sjwyy	439	11	'	'	''
cord-275730-650sjwyy	439	12	,	,	,
cord-275730-650sjwyy	439	13	5')-cyclic	5')-cyclic	CD
cord-275730-650sjwyy	439	14	dimeric	dimeric	JJ
cord-275730-650sjwyy	439	15	inosine	inosine	NNP
cord-275730-650sjwyy	439	16	monophosphate	monophosphate	NN
cord-275730-650sjwyy	439	17	exerts	exert	VBZ
cord-275730-650sjwyy	439	18	potent	potent	JJ
cord-275730-650sjwyy	439	19	activity	activity	NN
cord-275730-650sjwyy	439	20	as	as	IN
cord-275730-650sjwyy	439	21	mucosal	mucosal	JJ
cord-275730-650sjwyy	439	22	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	439	23	Cholera	cholera	NN
cord-275730-650sjwyy	439	24	toxin	toxin	NN
cord-275730-650sjwyy	439	25	and	and	CC
cord-275730-650sjwyy	439	26	its	-PRON-	PRP$
cord-275730-650sjwyy	439	27	b	b	NN
cord-275730-650sjwyy	439	28	subunit	subunit	NN
cord-275730-650sjwyy	439	29	promote	promote	VB
cord-275730-650sjwyy	439	30	dendritic	dendritic	JJ
cord-275730-650sjwyy	439	31	cell	cell	NN
cord-275730-650sjwyy	439	32	vaccination	vaccination	NN
cord-275730-650sjwyy	439	33	with	with	IN
cord-275730-650sjwyy	439	34	different	different	JJ
cord-275730-650sjwyy	439	35	influences	influence	NNS
cord-275730-650sjwyy	439	36	on	on	IN
cord-275730-650sjwyy	439	37	th1	th1	NNP
cord-275730-650sjwyy	439	38	and	and	CC
cord-275730-650sjwyy	439	39	th2	th2	NNP
cord-275730-650sjwyy	439	40	development	development	NN
cord-275730-650sjwyy	439	41	As04	As04	NNP
cord-275730-650sjwyy	439	42	,	,	,
cord-275730-650sjwyy	439	43	an	an	DT
cord-275730-650sjwyy	439	44	aluminum	aluminum	NN
cord-275730-650sjwyy	439	45	salt	salt	NN
cord-275730-650sjwyy	439	46	-	-	:
cord-275730-650sjwyy	439	47	and	and	CC
cord-275730-650sjwyy	439	48	tlr4	tlr4	CD
cord-275730-650sjwyy	439	49	agonist	agonist	NN
cord-275730-650sjwyy	439	50	-	-	HYPH
cord-275730-650sjwyy	439	51	based	base	VBN
cord-275730-650sjwyy	439	52	adjuvant	adjuvant	NN
cord-275730-650sjwyy	439	53	system	system	NN
cord-275730-650sjwyy	439	54	,	,	,
cord-275730-650sjwyy	439	55	induces	induce	VBZ
cord-275730-650sjwyy	439	56	a	a	DT
cord-275730-650sjwyy	439	57	transient	transient	JJ
cord-275730-650sjwyy	439	58	localized	localize	VBN
cord-275730-650sjwyy	439	59	innate	innate	JJ
cord-275730-650sjwyy	439	60	immune	immune	JJ
cord-275730-650sjwyy	439	61	response	response	NN
cord-275730-650sjwyy	439	62	leading	lead	VBG
cord-275730-650sjwyy	439	63	to	to	IN
cord-275730-650sjwyy	439	64	enhanced	enhanced	JJ
cord-275730-650sjwyy	439	65	adaptive	adaptive	JJ
cord-275730-650sjwyy	439	66	immunity	immunity	NN
cord-275730-650sjwyy	440	1	The	the	DT
cord-275730-650sjwyy	440	2	potential	potential	NN
cord-275730-650sjwyy	440	3	of	of	IN
cord-275730-650sjwyy	440	4	3',5'-cyclic	3',5'-cyclic	CD
cord-275730-650sjwyy	440	5	diguanylic	diguanylic	JJ
cord-275730-650sjwyy	440	6	acid	acid	NN
cord-275730-650sjwyy	440	7	(	(	-LRB-
cord-275730-650sjwyy	440	8	c	c	NNP
cord-275730-650sjwyy	440	9	-	-	HYPH
cord-275730-650sjwyy	440	10	di	di	NNP
cord-275730-650sjwyy	440	11	-	-	HYPH
cord-275730-650sjwyy	440	12	gmp	gmp	NNP
cord-275730-650sjwyy	440	13	)	)	-RRB-
cord-275730-650sjwyy	440	14	as	as	IN
cord-275730-650sjwyy	440	15	an	an	DT
cord-275730-650sjwyy	440	16	effective	effective	JJ
cord-275730-650sjwyy	440	17	vaccine	vaccine	NN
cord-275730-650sjwyy	440	18	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	440	19	Cyclic	Cyclic	NNP
cord-275730-650sjwyy	440	20	dinucleotide	dinucleotide	NN
cord-275730-650sjwyy	440	21	-	-	HYPH
cord-275730-650sjwyy	440	22	adjuvanted	adjuvante	VBN
cord-275730-650sjwyy	440	23	dengue	dengue	NN
cord-275730-650sjwyy	440	24	virus	virus	NN
cord-275730-650sjwyy	440	25	nonstructural	nonstructural	JJ
cord-275730-650sjwyy	440	26	protein	protein	NN
cord-275730-650sjwyy	440	27	1	1	CD
cord-275730-650sjwyy	440	28	induces	induce	VBZ
cord-275730-650sjwyy	440	29	protective	protective	JJ
cord-275730-650sjwyy	440	30	antibody	antibody	NN
cord-275730-650sjwyy	440	31	and	and	CC
cord-275730-650sjwyy	440	32	t	t	NN
cord-275730-650sjwyy	440	33	cell	cell	NN
cord-275730-650sjwyy	440	34	responses	response	NNS
cord-275730-650sjwyy	440	35	T	t	NN
cord-275730-650sjwyy	440	36	-	-	HYPH
cord-275730-650sjwyy	440	37	cell	cell	NN
cord-275730-650sjwyy	440	38	exhaustion	exhaustion	NN
cord-275730-650sjwyy	440	39	in	in	IN
cord-275730-650sjwyy	440	40	the	the	DT
cord-275730-650sjwyy	440	41	tumor	tumor	NN
cord-275730-650sjwyy	440	42	microenvironment	microenvironment	NN
cord-275730-650sjwyy	440	43	T	t	NN
cord-275730-650sjwyy	440	44	cell	cell	NN
cord-275730-650sjwyy	440	45	dysfunction	dysfunction	NN
cord-275730-650sjwyy	440	46	and	and	CC
cord-275730-650sjwyy	440	47	exhaustion	exhaustion	NN
cord-275730-650sjwyy	440	48	in	in	IN
cord-275730-650sjwyy	440	49	cancer	cancer	NN
cord-275730-650sjwyy	440	50	Sting	sting	NN
cord-275730-650sjwyy	440	51	activation	activation	NN
cord-275730-650sjwyy	440	52	of	of	IN
cord-275730-650sjwyy	440	53	tumor	tumor	NN
cord-275730-650sjwyy	440	54	endothelial	endothelial	JJ
cord-275730-650sjwyy	440	55	cells	cell	NNS
cord-275730-650sjwyy	440	56	initiates	initiate	VBZ
cord-275730-650sjwyy	440	57	spontaneous	spontaneous	JJ
cord-275730-650sjwyy	440	58	and	and	CC
cord-275730-650sjwyy	440	59	therapeutic	therapeutic	JJ
cord-275730-650sjwyy	440	60	antitumor	antitumor	NN
cord-275730-650sjwyy	440	61	immunity	immunity	NN
cord-275730-650sjwyy	441	1	Intratumoral	Intratumoral	NNP
cord-275730-650sjwyy	441	2	administration	administration	NN
cord-275730-650sjwyy	441	3	of	of	IN
cord-275730-650sjwyy	441	4	cgamp	cgamp	NNP
cord-275730-650sjwyy	441	5	transiently	transiently	RB
cord-275730-650sjwyy	441	6	accumulates	accumulate	VBZ
cord-275730-650sjwyy	441	7	potent	potent	JJ
cord-275730-650sjwyy	441	8	macrophages	macrophage	NNS
cord-275730-650sjwyy	441	9	for	for	IN
cord-275730-650sjwyy	441	10	anti	anti	JJ
cord-275730-650sjwyy	441	11	-	-	JJ
cord-275730-650sjwyy	441	12	tumor	tumor	JJ
cord-275730-650sjwyy	441	13	immunity	immunity	NN
cord-275730-650sjwyy	441	14	at	at	IN
cord-275730-650sjwyy	441	15	a	a	DT
cord-275730-650sjwyy	441	16	mouse	mouse	NN
cord-275730-650sjwyy	441	17	tumor	tumor	NN
cord-275730-650sjwyy	441	18	site	site	NN
cord-275730-650sjwyy	441	19	Nk	Nk	NNP
cord-275730-650sjwyy	441	20	cells	cell	NNS
cord-275730-650sjwyy	441	21	mediate	mediate	VBP
cord-275730-650sjwyy	441	22	clearance	clearance	NN
cord-275730-650sjwyy	441	23	of	of	IN
cord-275730-650sjwyy	441	24	cd8(+	cd8(+	CD
cord-275730-650sjwyy	441	25	)	)	-RRB-
cord-275730-650sjwyy	442	1	t	t	NNP
cord-275730-650sjwyy	442	2	cell	cell	NN
cord-275730-650sjwyy	442	3	-	-	HYPH
cord-275730-650sjwyy	442	4	resistant	resistant	JJ
cord-275730-650sjwyy	442	5	tumors	tumor	NNS
cord-275730-650sjwyy	442	6	in	in	IN
cord-275730-650sjwyy	442	7	response	response	NN
cord-275730-650sjwyy	442	8	to	to	IN
cord-275730-650sjwyy	442	9	sting	sting	NN
cord-275730-650sjwyy	442	10	agonists	agonist	NNS
cord-275730-650sjwyy	443	1	Tnfalpha	tnfalpha	NN
cord-275730-650sjwyy	443	2	and	and	CC
cord-275730-650sjwyy	443	3	radioresistant	radioresistant	NN
cord-275730-650sjwyy	443	4	stromal	stromal	NN
cord-275730-650sjwyy	443	5	cells	cell	NNS
cord-275730-650sjwyy	443	6	are	be	VBP
cord-275730-650sjwyy	443	7	essential	essential	JJ
cord-275730-650sjwyy	443	8	for	for	IN
cord-275730-650sjwyy	443	9	therapeutic	therapeutic	JJ
cord-275730-650sjwyy	443	10	efficacy	efficacy	NN
cord-275730-650sjwyy	443	11	of	of	IN
cord-275730-650sjwyy	443	12	cyclic	cyclic	JJ
cord-275730-650sjwyy	443	13	dinucleotide	dinucleotide	NN
cord-275730-650sjwyy	443	14	sting	sting	NN
cord-275730-650sjwyy	443	15	agonists	agonist	NNS
cord-275730-650sjwyy	443	16	in	in	IN
cord-275730-650sjwyy	443	17	nonimmunogenic	nonimmunogenic	NNP
cord-275730-650sjwyy	443	18	tumors	tumor	NNS
cord-275730-650sjwyy	444	1	The	the	DT
cord-275730-650sjwyy	444	2	combination	combination	NN
cord-275730-650sjwyy	444	3	vaccine	vaccine	NN
cord-275730-650sjwyy	444	4	adjuvant	adjuvant	NN
cord-275730-650sjwyy	444	5	system	system	NN
cord-275730-650sjwyy	444	6	alum	alum	NN
cord-275730-650sjwyy	444	7	/	/	SYM
cord-275730-650sjwyy	444	8	c	c	NNP
cord-275730-650sjwyy	444	9	-	-	HYPH
cord-275730-650sjwyy	444	10	di	di	NN
cord-275730-650sjwyy	444	11	-	-	HYPH
cord-275730-650sjwyy	444	12	amp	amp	NN
cord-275730-650sjwyy	444	13	results	result	NNS
cord-275730-650sjwyy	444	14	in	in	IN
cord-275730-650sjwyy	444	15	quantitative	quantitative	JJ
cord-275730-650sjwyy	444	16	and	and	CC
cord-275730-650sjwyy	444	17	qualitative	qualitative	JJ
cord-275730-650sjwyy	444	18	enhanced	enhance	VBN
cord-275730-650sjwyy	444	19	immune	immune	JJ
cord-275730-650sjwyy	444	20	responses	response	NNS
cord-275730-650sjwyy	444	21	post	post	VBP
cord-275730-650sjwyy	444	22	immunization	immunization	NN
cord-275730-650sjwyy	444	23	Comparison	comparison	NN
cord-275730-650sjwyy	444	24	of	of	IN
cord-275730-650sjwyy	444	25	the	the	DT
cord-275730-650sjwyy	444	26	oral	oral	JJ
cord-275730-650sjwyy	444	27	,	,	,
cord-275730-650sjwyy	444	28	rectal	rectal	JJ
cord-275730-650sjwyy	444	29	,	,	,
cord-275730-650sjwyy	444	30	and	and	CC
cord-275730-650sjwyy	444	31	vaginal	vaginal	JJ
cord-275730-650sjwyy	444	32	immunization	immunization	NN
cord-275730-650sjwyy	444	33	routes	route	NNS
cord-275730-650sjwyy	444	34	for	for	IN
cord-275730-650sjwyy	444	35	induction	induction	NN
cord-275730-650sjwyy	444	36	of	of	IN
cord-275730-650sjwyy	444	37	antibodies	antibody	NNS
cord-275730-650sjwyy	444	38	in	in	IN
cord-275730-650sjwyy	444	39	rectal	rectal	JJ
cord-275730-650sjwyy	444	40	and	and	CC
cord-275730-650sjwyy	444	41	genital	genital	JJ
cord-275730-650sjwyy	444	42	tract	tract	JJ
cord-275730-650sjwyy	444	43	secretions	secretion	NNS
cord-275730-650sjwyy	444	44	of	of	IN
cord-275730-650sjwyy	444	45	women	woman	NNS
cord-275730-650sjwyy	444	46	Differential	differential	JJ
cord-275730-650sjwyy	444	47	induction	induction	NN
cord-275730-650sjwyy	444	48	of	of	IN
cord-275730-650sjwyy	444	49	mucosal	mucosal	JJ
cord-275730-650sjwyy	444	50	and	and	CC
cord-275730-650sjwyy	444	51	systemic	systemic	JJ
cord-275730-650sjwyy	444	52	antibody	antibody	NN
cord-275730-650sjwyy	444	53	responses	response	NNS
cord-275730-650sjwyy	444	54	in	in	IN
cord-275730-650sjwyy	444	55	women	woman	NNS
cord-275730-650sjwyy	444	56	after	after	IN
cord-275730-650sjwyy	444	57	nasal	nasal	NN
cord-275730-650sjwyy	444	58	,	,	,
cord-275730-650sjwyy	444	59	rectal	rectal	JJ
cord-275730-650sjwyy	444	60	,	,	,
cord-275730-650sjwyy	444	61	or	or	CC
cord-275730-650sjwyy	444	62	vaginal	vaginal	JJ
cord-275730-650sjwyy	444	63	immunization	immunization	NN
cord-275730-650sjwyy	444	64	:	:	:
cord-275730-650sjwyy	444	65	Influence	influence	NN
cord-275730-650sjwyy	444	66	of	of	IN
cord-275730-650sjwyy	444	67	the	the	DT
cord-275730-650sjwyy	444	68	menstrual	menstrual	JJ
cord-275730-650sjwyy	444	69	cycle	cycle	NN
cord-275730-650sjwyy	445	1	Intranasal	intranasal	NN
cord-275730-650sjwyy	445	2	immunization	immunization	NN
cord-275730-650sjwyy	445	3	is	be	VBZ
cord-275730-650sjwyy	445	4	superior	superior	JJ
cord-275730-650sjwyy	445	5	to	to	IN
cord-275730-650sjwyy	445	6	vaginal	vaginal	JJ
cord-275730-650sjwyy	445	7	,	,	,
cord-275730-650sjwyy	445	8	gastric	gastric	JJ
cord-275730-650sjwyy	445	9	,	,	,
cord-275730-650sjwyy	445	10	or	or	CC
cord-275730-650sjwyy	445	11	rectal	rectal	JJ
cord-275730-650sjwyy	445	12	immunization	immunization	NN
cord-275730-650sjwyy	445	13	for	for	IN
cord-275730-650sjwyy	445	14	the	the	DT
cord-275730-650sjwyy	445	15	induction	induction	NN
cord-275730-650sjwyy	445	16	of	of	IN
cord-275730-650sjwyy	445	17	systemic	systemic	JJ
cord-275730-650sjwyy	445	18	and	and	CC
cord-275730-650sjwyy	445	19	mucosal	mucosal	JJ
cord-275730-650sjwyy	445	20	anti	anti	JJ
cord-275730-650sjwyy	445	21	-	-	JJ
cord-275730-650sjwyy	445	22	hiv	hiv	JJ
cord-275730-650sjwyy	445	23	antibody	antibody	NN
cord-275730-650sjwyy	445	24	responses	response	VBZ
cord-275730-650sjwyy	445	25	Nasal	Nasal	NNP
cord-275730-650sjwyy	445	26	immunization	immunization	NN
cord-275730-650sjwyy	445	27	of	of	IN
cord-275730-650sjwyy	445	28	nonhuman	nonhuman	NN
cord-275730-650sjwyy	445	29	primates	primate	NNS
cord-275730-650sjwyy	445	30	with	with	IN
cord-275730-650sjwyy	445	31	simian	simian	JJ
cord-275730-650sjwyy	445	32	immunodeficiency	immunodeficiency	NN
cord-275730-650sjwyy	445	33	virus	virus	NN
cord-275730-650sjwyy	445	34	p55gag	p55gag	NN
cord-275730-650sjwyy	445	35	and	and	CC
cord-275730-650sjwyy	445	36	cholera	cholera	NN
cord-275730-650sjwyy	445	37	toxin	toxin	NN
cord-275730-650sjwyy	445	38	adjuvant	adjuvant	NN
cord-275730-650sjwyy	445	39	induces	induce	VBZ
cord-275730-650sjwyy	445	40	th1	th1	NNP
cord-275730-650sjwyy	445	41	/	/	SYM
cord-275730-650sjwyy	445	42	th2	th2	NNP
cord-275730-650sjwyy	445	43	help	help	NN
cord-275730-650sjwyy	445	44	for	for	IN
cord-275730-650sjwyy	445	45	virus	virus	NN
cord-275730-650sjwyy	445	46	-	-	HYPH
cord-275730-650sjwyy	445	47	specific	specific	JJ
cord-275730-650sjwyy	445	48	immune	immune	JJ
cord-275730-650sjwyy	445	49	responses	response	NNS
cord-275730-650sjwyy	445	50	in	in	IN
cord-275730-650sjwyy	445	51	reproductive	reproductive	JJ
cord-275730-650sjwyy	445	52	tissues	tissue	NNS
cord-275730-650sjwyy	445	53	Antibody	Antibody	NNP
cord-275730-650sjwyy	445	54	responses	response	NNS
cord-275730-650sjwyy	445	55	in	in	IN
cord-275730-650sjwyy	445	56	the	the	DT
cord-275730-650sjwyy	445	57	lower	low	JJR
cord-275730-650sjwyy	445	58	respiratory	respiratory	JJ
cord-275730-650sjwyy	445	59	tract	tract	NN
cord-275730-650sjwyy	445	60	and	and	CC
cord-275730-650sjwyy	445	61	male	male	JJ
cord-275730-650sjwyy	445	62	urogenital	urogenital	JJ
cord-275730-650sjwyy	445	63	tract	tract	NN
cord-275730-650sjwyy	445	64	in	in	IN
cord-275730-650sjwyy	445	65	humans	human	NNS
cord-275730-650sjwyy	445	66	after	after	IN
cord-275730-650sjwyy	445	67	nasal	nasal	NN
cord-275730-650sjwyy	445	68	and	and	CC
cord-275730-650sjwyy	445	69	oral	oral	JJ
cord-275730-650sjwyy	445	70	vaccination	vaccination	NN
cord-275730-650sjwyy	445	71	with	with	IN
cord-275730-650sjwyy	445	72	cholera	cholera	NN
cord-275730-650sjwyy	445	73	toxin	toxin	NN
cord-275730-650sjwyy	445	74	b	b	NNP
cord-275730-650sjwyy	445	75	subunit	subunit	NN
cord-275730-650sjwyy	446	1	A	a	DT
cord-275730-650sjwyy	446	2	comparative	comparative	JJ
cord-275730-650sjwyy	446	3	evaluation	evaluation	NN
cord-275730-650sjwyy	446	4	of	of	IN
cord-275730-650sjwyy	446	5	nasal	nasal	NN
cord-275730-650sjwyy	446	6	and	and	CC
cord-275730-650sjwyy	446	7	parenteral	parenteral	JJ
cord-275730-650sjwyy	446	8	vaccine	vaccine	NN
cord-275730-650sjwyy	446	9	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	446	10	to	to	TO
cord-275730-650sjwyy	446	11	elicit	elicit	VB
cord-275730-650sjwyy	446	12	systemic	systemic	JJ
cord-275730-650sjwyy	446	13	and	and	CC
cord-275730-650sjwyy	446	14	mucosal	mucosal	JJ
cord-275730-650sjwyy	446	15	hiv-1	hiv-1	NNP
cord-275730-650sjwyy	446	16	peptide	peptide	NN
cord-275730-650sjwyy	446	17	-	-	HYPH
cord-275730-650sjwyy	446	18	specific	specific	JJ
cord-275730-650sjwyy	446	19	humoral	humoral	JJ
cord-275730-650sjwyy	446	20	immune	immune	JJ
cord-275730-650sjwyy	446	21	responses	response	NNS
cord-275730-650sjwyy	446	22	in	in	IN
cord-275730-650sjwyy	446	23	cynomolgus	cynomolgus	JJ
cord-275730-650sjwyy	446	24	macaques	macaque	NNS
cord-275730-650sjwyy	446	25	Mucosal	Mucosal	NNP
cord-275730-650sjwyy	446	26	immunization	immunization	NN
cord-275730-650sjwyy	446	27	with	with	IN
cord-275730-650sjwyy	446	28	hiv-1	hiv-1	NNP
cord-275730-650sjwyy	446	29	peptide	peptide	JJ
cord-275730-650sjwyy	446	30	vaccine	vaccine	NN
cord-275730-650sjwyy	446	31	induces	induce	VBZ
cord-275730-650sjwyy	446	32	mucosal	mucosal	JJ
cord-275730-650sjwyy	446	33	and	and	CC
cord-275730-650sjwyy	446	34	systemic	systemic	JJ
cord-275730-650sjwyy	446	35	cytotoxic	cytotoxic	JJ
cord-275730-650sjwyy	446	36	t	t	NN
cord-275730-650sjwyy	446	37	lymphocytes	lymphocyte	NNS
cord-275730-650sjwyy	446	38	and	and	CC
cord-275730-650sjwyy	446	39	protective	protective	JJ
cord-275730-650sjwyy	446	40	immunity	immunity	NN
cord-275730-650sjwyy	446	41	in	in	IN
cord-275730-650sjwyy	446	42	mice	mouse	NNS
cord-275730-650sjwyy	446	43	against	against	IN
cord-275730-650sjwyy	446	44	intrarectal	intrarectal	NNP
cord-275730-650sjwyy	446	45	recombinant	recombinant	JJ
cord-275730-650sjwyy	446	46	hiv	hiv	NNP
cord-275730-650sjwyy	446	47	-	-	HYPH
cord-275730-650sjwyy	446	48	vaccinia	vaccinia	NN
cord-275730-650sjwyy	446	49	challenge	challenge	NN
cord-275730-650sjwyy	447	1	Recent	recent	JJ
cord-275730-650sjwyy	447	2	progress	progress	NN
cord-275730-650sjwyy	447	3	in	in	IN
cord-275730-650sjwyy	447	4	mucosal	mucosal	JJ
cord-275730-650sjwyy	447	5	vaccine	vaccine	NN
cord-275730-650sjwyy	447	6	development	development	NN
cord-275730-650sjwyy	447	7	:	:	:
cord-275730-650sjwyy	448	1	Potential	potential	JJ
cord-275730-650sjwyy	448	2	and	and	CC
cord-275730-650sjwyy	448	3	limitations	limitation	NNS
cord-275730-650sjwyy	448	4	Cutting	cut	VBG
cord-275730-650sjwyy	448	5	edge	edge	NN
cord-275730-650sjwyy	448	6	:	:	:
cord-275730-650sjwyy	448	7	The	the	DT
cord-275730-650sjwyy	448	8	mucosal	mucosal	JJ
cord-275730-650sjwyy	448	9	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	448	10	cholera	cholera	NN
cord-275730-650sjwyy	448	11	toxin	toxin	NN
cord-275730-650sjwyy	448	12	redirects	redirect	VBZ
cord-275730-650sjwyy	448	13	vaccine	vaccine	NN
cord-275730-650sjwyy	448	14	proteins	protein	NNS
cord-275730-650sjwyy	448	15	into	into	IN
cord-275730-650sjwyy	448	16	olfactory	olfactory	JJ
cord-275730-650sjwyy	448	17	tissues	tissue	NNS
cord-275730-650sjwyy	448	18	Use	use	VB
cord-275730-650sjwyy	448	19	of	of	IN
cord-275730-650sjwyy	448	20	the	the	DT
cord-275730-650sjwyy	448	21	inactivated	inactivate	VBN
cord-275730-650sjwyy	448	22	intranasal	intranasal	NN
cord-275730-650sjwyy	448	23	influenza	influenza	NN
cord-275730-650sjwyy	448	24	vaccine	vaccine	NN
cord-275730-650sjwyy	448	25	and	and	CC
cord-275730-650sjwyy	448	26	the	the	DT
cord-275730-650sjwyy	448	27	risk	risk	NN
cord-275730-650sjwyy	448	28	of	of	IN
cord-275730-650sjwyy	448	29	bell	bell	NNP
cord-275730-650sjwyy	448	30	's	's	POS
cord-275730-650sjwyy	448	31	palsy	palsy	NNP
cord-275730-650sjwyy	448	32	in	in	IN
cord-275730-650sjwyy	448	33	switzerland	switzerland	NNP
cord-275730-650sjwyy	448	34	Nasal	Nasal	NNP
cord-275730-650sjwyy	448	35	vaccination	vaccination	NN
cord-275730-650sjwyy	448	36	,	,	,
cord-275730-650sjwyy	448	37	escherichia	escherichia	NN
cord-275730-650sjwyy	448	38	coli	coli	NNP
cord-275730-650sjwyy	448	39	enterotoxin	enterotoxin	NNP
cord-275730-650sjwyy	448	40	,	,	,
cord-275730-650sjwyy	448	41	and	and	CC
cord-275730-650sjwyy	448	42	bell	bell	NNP
cord-275730-650sjwyy	448	43	's	's	POS
cord-275730-650sjwyy	448	44	palsy	palsy	NNP
cord-275730-650sjwyy	449	1	The	the	DT
cord-275730-650sjwyy	449	2	mucosal	mucosal	JJ
cord-275730-650sjwyy	449	3	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	449	4	cyclic	cyclic	NN
cord-275730-650sjwyy	449	5	di	di	NNP
cord-275730-650sjwyy	449	6	-	-	HYPH
cord-275730-650sjwyy	449	7	gmp	gmp	NNP
cord-275730-650sjwyy	449	8	enhances	enhance	VBZ
cord-275730-650sjwyy	449	9	antigen	antigen	NN
cord-275730-650sjwyy	449	10	uptake	uptake	NN
cord-275730-650sjwyy	449	11	and	and	CC
cord-275730-650sjwyy	449	12	selectively	selectively	RB
cord-275730-650sjwyy	449	13	activates	activate	VBZ
cord-275730-650sjwyy	449	14	pinocytosis	pinocytosis	NN
cord-275730-650sjwyy	449	15	-	-	HYPH
cord-275730-650sjwyy	449	16	efficient	efficient	JJ
cord-275730-650sjwyy	449	17	cells	cell	NNS
cord-275730-650sjwyy	449	18	in	in	IN
cord-275730-650sjwyy	449	19	vivo	vivo	NN
cord-275730-650sjwyy	449	20	Cutting	cut	VBG
cord-275730-650sjwyy	449	21	edge	edge	NN
cord-275730-650sjwyy	449	22	:	:	:
cord-275730-650sjwyy	449	23	DNA	dna	NN
cord-275730-650sjwyy	449	24	sensing	sensing	NN
cord-275730-650sjwyy	449	25	via	via	IN
cord-275730-650sjwyy	449	26	the	the	DT
cord-275730-650sjwyy	449	27	sting	sting	NN
cord-275730-650sjwyy	449	28	adaptor	adaptor	NN
cord-275730-650sjwyy	449	29	in	in	IN
cord-275730-650sjwyy	449	30	myeloid	myeloid	JJ
cord-275730-650sjwyy	449	31	dendritic	dendritic	JJ
cord-275730-650sjwyy	449	32	cells	cell	NNS
cord-275730-650sjwyy	449	33	induces	induce	VBZ
cord-275730-650sjwyy	449	34	potent	potent	JJ
cord-275730-650sjwyy	449	35	tolerogenic	tolerogenic	NNP
cord-275730-650sjwyy	449	36	responses	response	NNS
cord-275730-650sjwyy	449	37	Activation	Activation	NNP
cord-275730-650sjwyy	449	38	of	of	IN
cord-275730-650sjwyy	449	39	the	the	DT
cord-275730-650sjwyy	449	40	sting	sting	NN
cord-275730-650sjwyy	449	41	adaptor	adaptor	NN
cord-275730-650sjwyy	449	42	attenuates	attenuate	VBZ
cord-275730-650sjwyy	450	1	experimental	experimental	JJ
cord-275730-650sjwyy	450	2	autoimmune	autoimmune	JJ
cord-275730-650sjwyy	450	3	encephalitis	encephalitis	RB
cord-275730-650sjwyy	450	4	Sting	Sting	NNP
cord-275730-650sjwyy	450	5	promotes	promote	VBZ
cord-275730-650sjwyy	450	6	the	the	DT
cord-275730-650sjwyy	450	7	growth	growth	NN
cord-275730-650sjwyy	450	8	of	of	IN
cord-275730-650sjwyy	450	9	tumors	tumor	NNS
cord-275730-650sjwyy	450	10	characterized	characterize	VBN
cord-275730-650sjwyy	450	11	by	by	IN
cord-275730-650sjwyy	450	12	low	low	JJ
cord-275730-650sjwyy	450	13	antigenicity	antigenicity	NN
cord-275730-650sjwyy	450	14	via	via	IN
cord-275730-650sjwyy	450	15	ido	ido	NNP
cord-275730-650sjwyy	450	16	activation	activation	NN
cord-275730-650sjwyy	450	17	Stimulator	Stimulator	NNP
cord-275730-650sjwyy	450	18	of	of	IN
cord-275730-650sjwyy	450	19	interferon	interferon	NN
cord-275730-650sjwyy	450	20	genes	gene	NNS
cord-275730-650sjwyy	450	21	agonists	agonist	NNS
cord-275730-650sjwyy	451	1	attenuate	attenuate	VB
cord-275730-650sjwyy	451	2	type	type	NN
cord-275730-650sjwyy	452	1	i	i	PRP
cord-275730-650sjwyy	452	2	diabetes	diabete	VBZ
cord-275730-650sjwyy	452	3	progression	progression	NN
cord-275730-650sjwyy	452	4	in	in	IN
cord-275730-650sjwyy	452	5	nod	nod	JJ
cord-275730-650sjwyy	452	6	mice	mouse	NNS
cord-275730-650sjwyy	453	1	Immunomodulatory	immunomodulatory	JJ
cord-275730-650sjwyy	453	2	activity	activity	NN
cord-275730-650sjwyy	453	3	of	of	IN
cord-275730-650sjwyy	453	4	interferon	interferon	NN
cord-275730-650sjwyy	453	5	-	-	HYPH
cord-275730-650sjwyy	453	6	beta	beta	NN
cord-275730-650sjwyy	453	7	Sting	Sting	NNP
cord-275730-650sjwyy	453	8	is	be	VBZ
cord-275730-650sjwyy	453	9	a	a	DT
cord-275730-650sjwyy	453	10	direct	direct	JJ
cord-275730-650sjwyy	453	11	innate	innate	JJ
cord-275730-650sjwyy	453	12	immune	immune	JJ
cord-275730-650sjwyy	453	13	sensor	sensor	NN
cord-275730-650sjwyy	453	14	of	of	IN
cord-275730-650sjwyy	453	15	cyclic	cyclic	JJ
cord-275730-650sjwyy	453	16	di	di	FW
cord-275730-650sjwyy	453	17	-	-	HYPH
cord-275730-650sjwyy	453	18	gmp	gmp	NNP
cord-275730-650sjwyy	453	19	Selective	selective	JJ
cord-275730-650sjwyy	453	20	loss	loss	NN
cord-275730-650sjwyy	453	21	of	of	IN
cord-275730-650sjwyy	453	22	responsiveness	responsiveness	NN
cord-275730-650sjwyy	453	23	to	to	IN
cord-275730-650sjwyy	453	24	exogenous	exogenous	JJ
cord-275730-650sjwyy	453	25	but	but	CC
cord-275730-650sjwyy	453	26	not	not	RB
cord-275730-650sjwyy	453	27	endogenous	endogenous	JJ
cord-275730-650sjwyy	453	28	cyclic	cyclic	JJ
cord-275730-650sjwyy	453	29	-	-	HYPH
cord-275730-650sjwyy	453	30	dinucleotides	dinucleotide	NNS
cord-275730-650sjwyy	453	31	in	in	IN
cord-275730-650sjwyy	453	32	mice	mouse	NNS
cord-275730-650sjwyy	453	33	expressing	express	VBG
cord-275730-650sjwyy	453	34	sting	sting	NN
cord-275730-650sjwyy	453	35	-	-	HYPH
cord-275730-650sjwyy	453	36	r231h	r231h	NNP
cord-275730-650sjwyy	453	37	.	.	.
cord-275730-650sjwyy	454	1	Front	front	VB
cord-275730-650sjwyy	454	2	The	the	DT
cord-275730-650sjwyy	454	3	common	common	JJ
cord-275730-650sjwyy	454	4	r71h	r71h	NNS
cord-275730-650sjwyy	454	5	-	-	HYPH
cord-275730-650sjwyy	454	6	g230a	g230a	CD
cord-275730-650sjwyy	454	7	-	-	HYPH
cord-275730-650sjwyy	454	8	r293q	r293q	CD
cord-275730-650sjwyy	454	9	human	human	JJ
cord-275730-650sjwyy	454	10	tmem173	tmem173	NN
cord-275730-650sjwyy	454	11	is	be	VBZ
cord-275730-650sjwyy	454	12	a	a	DT
cord-275730-650sjwyy	454	13	null	null	JJ
cord-275730-650sjwyy	454	14	allele	allele	NN
cord-275730-650sjwyy	454	15	Mpys	Mpys	NNP
cord-275730-650sjwyy	454	16	/	/	SYM
cord-275730-650sjwyy	454	17	sting	sting	NN
cord-275730-650sjwyy	454	18	-	-	HYPH
cord-275730-650sjwyy	454	19	mediated	mediate	VBN
cord-275730-650sjwyy	454	20	tnf	tnf	NN
cord-275730-650sjwyy	454	21	-	-	HYPH
cord-275730-650sjwyy	454	22	alpha	alpha	NN
cord-275730-650sjwyy	454	23	,	,	,
cord-275730-650sjwyy	454	24	not	not	RB
cord-275730-650sjwyy	454	25	type	type	NN
cord-275730-650sjwyy	454	26	i	i	PRP
cord-275730-650sjwyy	454	27	ifn	ifn	NNP
cord-275730-650sjwyy	454	28	,	,	,
cord-275730-650sjwyy	454	29	is	be	VBZ
cord-275730-650sjwyy	454	30	essential	essential	JJ
cord-275730-650sjwyy	454	31	for	for	IN
cord-275730-650sjwyy	454	32	the	the	DT
cord-275730-650sjwyy	454	33	mucosal	mucosal	JJ
cord-275730-650sjwyy	454	34	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	454	35	activity	activity	NN
cord-275730-650sjwyy	454	36	of	of	IN
cord-275730-650sjwyy	454	37	(	(	-LRB-
cord-275730-650sjwyy	454	38	3'-5')-cyclic	3'-5')-cyclic	CD
cord-275730-650sjwyy	454	39	-	-	HYPH
cord-275730-650sjwyy	454	40	di	di	NN
cord-275730-650sjwyy	454	41	-	-	HYPH
cord-275730-650sjwyy	454	42	guanosine	guanosine	NN
cord-275730-650sjwyy	454	43	-	-	HYPH
cord-275730-650sjwyy	454	44	monophosphate	monophosphate	NN
cord-275730-650sjwyy	454	45	in	in	IN
cord-275730-650sjwyy	454	46	vivo	vivo	NN
cord-275730-650sjwyy	455	1	Positively	positively	RB
cord-275730-650sjwyy	455	2	charged	charge	VBN
cord-275730-650sjwyy	455	3	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	455	4	for	for	IN
cord-275730-650sjwyy	455	5	improving	improve	VBG
cord-275730-650sjwyy	455	6	the	the	DT
cord-275730-650sjwyy	455	7	oral	oral	JJ
cord-275730-650sjwyy	455	8	bioavailability	bioavailability	NN
cord-275730-650sjwyy	455	9	of	of	IN
cord-275730-650sjwyy	455	10	cyclosporin	cyclosporin	NN
cord-275730-650sjwyy	455	11	-	-	:
cord-275730-650sjwyy	455	12	a	a	DT
cord-275730-650sjwyy	455	13	Solid	solid	JJ
cord-275730-650sjwyy	455	14	lipid	lipid	NN
cord-275730-650sjwyy	455	15	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	455	16	(	(	-LRB-
cord-275730-650sjwyy	455	17	slns	slns	NNP
cord-275730-650sjwyy	455	18	)	)	-RRB-
cord-275730-650sjwyy	455	19	to	to	TO
cord-275730-650sjwyy	455	20	improve	improve	VB
cord-275730-650sjwyy	455	21	oral	oral	JJ
cord-275730-650sjwyy	455	22	bioavailability	bioavailability	NN
cord-275730-650sjwyy	455	23	of	of	IN
cord-275730-650sjwyy	455	24	poorly	poorly	RB
cord-275730-650sjwyy	455	25	soluble	soluble	JJ
cord-275730-650sjwyy	455	26	drugs	drug	NNS
cord-275730-650sjwyy	455	27	Submicron	Submicron	NNP
cord-275730-650sjwyy	455	28	-	-	HYPH
cord-275730-650sjwyy	455	29	sized	sized	JJ
cord-275730-650sjwyy	455	30	hydrogels	hydrogel	NNS
cord-275730-650sjwyy	455	31	incorporating	incorporate	VBG
cord-275730-650sjwyy	455	32	cyclic	cyclic	JJ
cord-275730-650sjwyy	455	33	dinucleotides	dinucleotide	NNS
cord-275730-650sjwyy	455	34	for	for	IN
cord-275730-650sjwyy	455	35	selective	selective	JJ
cord-275730-650sjwyy	455	36	delivery	delivery	NN
cord-275730-650sjwyy	455	37	and	and	CC
cord-275730-650sjwyy	455	38	elevated	elevated	JJ
cord-275730-650sjwyy	455	39	cytokine	cytokine	NN
cord-275730-650sjwyy	455	40	release	release	NN
cord-275730-650sjwyy	455	41	in	in	IN
cord-275730-650sjwyy	455	42	macrophages	macrophage	NNS
cord-275730-650sjwyy	455	43	Biodegradable	biodegradable	JJ
cord-275730-650sjwyy	455	44	sting	sting	NN
cord-275730-650sjwyy	455	45	agonist	agonist	NN
cord-275730-650sjwyy	455	46	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	455	47	for	for	IN
cord-275730-650sjwyy	455	48	enhanced	enhanced	JJ
cord-275730-650sjwyy	455	49	cancer	cancer	NN
cord-275730-650sjwyy	455	50	immunotherapy	immunotherapy	NN
cord-275730-650sjwyy	455	51	A	a	DT
cord-275730-650sjwyy	455	52	microparticle	microparticle	NNP
cord-275730-650sjwyy	455	53	platform	platform	NN
cord-275730-650sjwyy	455	54	for	for	IN
cord-275730-650sjwyy	455	55	sting	sting	NN
cord-275730-650sjwyy	455	56	-	-	HYPH
cord-275730-650sjwyy	455	57	targeted	target	VBN
cord-275730-650sjwyy	455	58	immunotherapy	immunotherapy	NN
cord-275730-650sjwyy	455	59	enhances	enhance	VBZ
cord-275730-650sjwyy	455	60	natural	natural	JJ
cord-275730-650sjwyy	455	61	killer	killer	NN
cord-275730-650sjwyy	455	62	cell	cell	NN
cord-275730-650sjwyy	455	63	-	-	HYPH
cord-275730-650sjwyy	455	64	and	and	CC
cord-275730-650sjwyy	455	65	cd8(+	cd8(+	CD
cord-275730-650sjwyy	455	66	)	)	-RRB-
cord-275730-650sjwyy	456	1	t	t	NNP
cord-275730-650sjwyy	456	2	cell	cell	NN
cord-275730-650sjwyy	456	3	-	-	HYPH
cord-275730-650sjwyy	456	4	mediated	mediate	VBN
cord-275730-650sjwyy	456	5	anti	anti	JJ
cord-275730-650sjwyy	456	6	-	-	JJ
cord-275730-650sjwyy	456	7	tumor	tumor	JJ
cord-275730-650sjwyy	456	8	immunity	immunity	NN
cord-275730-650sjwyy	457	1	Nanoparticulate	Nanoparticulate	NNP
cord-275730-650sjwyy	457	2	sting	sting	NN
cord-275730-650sjwyy	457	3	agonists	agonist	NNS
cord-275730-650sjwyy	457	4	are	be	VBP
cord-275730-650sjwyy	457	5	potent	potent	JJ
cord-275730-650sjwyy	457	6	lymph	lymph	NN
cord-275730-650sjwyy	457	7	node	node	NN
cord-275730-650sjwyy	457	8	-	-	HYPH
cord-275730-650sjwyy	457	9	targeted	target	VBN
cord-275730-650sjwyy	457	10	vaccine	vaccine	NN
cord-275730-650sjwyy	457	11	adjuvants	adjuvant	NNS
cord-275730-650sjwyy	458	1	Innate	innate	JJ
cord-275730-650sjwyy	458	2	immune	immune	JJ
cord-275730-650sjwyy	458	3	activation	activation	NN
cord-275730-650sjwyy	458	4	by	by	IN
cord-275730-650sjwyy	458	5	cgmp	cgmp	NNP
cord-275730-650sjwyy	458	6	-	-	HYPH
cord-275730-650sjwyy	458	7	amp	amp	NN
cord-275730-650sjwyy	458	8	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	458	9	leads	lead	VBZ
cord-275730-650sjwyy	458	10	to	to	IN
cord-275730-650sjwyy	458	11	potent	potent	JJ
cord-275730-650sjwyy	458	12	and	and	CC
cord-275730-650sjwyy	458	13	long	long	RB
cord-275730-650sjwyy	458	14	-	-	HYPH
cord-275730-650sjwyy	458	15	acting	act	VBG
cord-275730-650sjwyy	458	16	antiretroviral	antiretroviral	JJ
cord-275730-650sjwyy	458	17	response	response	NN
cord-275730-650sjwyy	458	18	against	against	IN
cord-275730-650sjwyy	458	19	hiv-1	hiv-1	NNP
cord-275730-650sjwyy	458	20	Stingel	Stingel	NNP
cord-275730-650sjwyy	458	21	:	:	:
cord-275730-650sjwyy	458	22	Controlled	control	VBN
cord-275730-650sjwyy	458	23	release	release	NN
cord-275730-650sjwyy	458	24	of	of	IN
cord-275730-650sjwyy	458	25	a	a	DT
cord-275730-650sjwyy	458	26	cyclic	cyclic	JJ
cord-275730-650sjwyy	458	27	dinucleotide	dinucleotide	NN
cord-275730-650sjwyy	458	28	for	for	IN
cord-275730-650sjwyy	458	29	enhanced	enhanced	JJ
cord-275730-650sjwyy	458	30	cancer	cancer	NN
cord-275730-650sjwyy	458	31	immunotherapy	immunotherapy	NN
cord-275730-650sjwyy	459	1	A	a	DT
cord-275730-650sjwyy	459	2	new	new	JJ
cord-275730-650sjwyy	459	3	adjuvant	adjuvant	NN
cord-275730-650sjwyy	459	4	delivery	delivery	NN
cord-275730-650sjwyy	459	5	system	system	NN
cord-275730-650sjwyy	459	6	'	'	POS
cord-275730-650sjwyy	459	7	cyclic	cyclic	JJ
cord-275730-650sjwyy	459	8	di	di	FW
cord-275730-650sjwyy	459	9	-	-	HYPH
cord-275730-650sjwyy	459	10	gmp	gmp	NNP
cord-275730-650sjwyy	459	11	/	/	SYM
cord-275730-650sjwyy	459	12	ysk05	ysk05	NNP
cord-275730-650sjwyy	459	13	liposome	liposome	NN
cord-275730-650sjwyy	459	14	'	'	''
cord-275730-650sjwyy	459	15	for	for	IN
cord-275730-650sjwyy	459	16	cancer	cancer	NN
cord-275730-650sjwyy	459	17	immunotherapy	immunotherapy	NN
cord-275730-650sjwyy	459	18	Magnitude	magnitude	NN
cord-275730-650sjwyy	459	19	of	of	IN
cord-275730-650sjwyy	459	20	therapeutic	therapeutic	JJ
cord-275730-650sjwyy	459	21	sting	sting	NN
cord-275730-650sjwyy	459	22	activation	activation	NN
cord-275730-650sjwyy	459	23	determines	determine	VBZ
cord-275730-650sjwyy	459	24	cd8(+	cd8(+	CD
cord-275730-650sjwyy	459	25	)	)	-RRB-
cord-275730-650sjwyy	460	1	t	t	NNP
cord-275730-650sjwyy	460	2	cell	cell	NN
cord-275730-650sjwyy	460	3	-	-	HYPH
cord-275730-650sjwyy	460	4	mediated	mediate	VBN
cord-275730-650sjwyy	460	5	anti	anti	JJ
cord-275730-650sjwyy	460	6	-	-	JJ
cord-275730-650sjwyy	460	7	tumor	tumor	JJ
cord-275730-650sjwyy	460	8	immunity	immunity	NN
cord-275730-650sjwyy	461	1	Endosomolytic	Endosomolytic	NNP
cord-275730-650sjwyy	461	2	polymersomes	polymersome	NNS
cord-275730-650sjwyy	461	3	increase	increase	VBP
cord-275730-650sjwyy	461	4	the	the	DT
cord-275730-650sjwyy	461	5	activity	activity	NN
cord-275730-650sjwyy	461	6	of	of	IN
cord-275730-650sjwyy	461	7	cyclic	cyclic	JJ
cord-275730-650sjwyy	461	8	dinucleotide	dinucleotide	NN
cord-275730-650sjwyy	461	9	sting	sting	NN
cord-275730-650sjwyy	461	10	agonists	agonist	NNS
cord-275730-650sjwyy	461	11	to	to	TO
cord-275730-650sjwyy	461	12	enhance	enhance	VB
cord-275730-650sjwyy	461	13	cancer	cancer	NN
cord-275730-650sjwyy	461	14	immunotherapy	immunotherapy	NN
cord-275730-650sjwyy	461	15	Liposomal	Liposomal	NNP
cord-275730-650sjwyy	461	16	delivery	delivery	NN
cord-275730-650sjwyy	462	1	enhances	enhance	VBZ
cord-275730-650sjwyy	462	2	immune	immune	JJ
cord-275730-650sjwyy	462	3	activation	activation	NN
cord-275730-650sjwyy	462	4	by	by	IN
cord-275730-650sjwyy	462	5	sting	sting	NN
cord-275730-650sjwyy	462	6	agonists	agonist	NNS
cord-275730-650sjwyy	462	7	for	for	IN
cord-275730-650sjwyy	462	8	cancer	cancer	NN
cord-275730-650sjwyy	462	9	immunotherapy	immunotherapy	NN
cord-275730-650sjwyy	462	10	Induction	Induction	NNP
cord-275730-650sjwyy	462	11	of	of	IN
cord-275730-650sjwyy	462	12	necrotic	necrotic	JJ
cord-275730-650sjwyy	462	13	cell	cell	NN
cord-275730-650sjwyy	462	14	death	death	NN
cord-275730-650sjwyy	462	15	and	and	CC
cord-275730-650sjwyy	462	16	activation	activation	NN
cord-275730-650sjwyy	462	17	of	of	IN
cord-275730-650sjwyy	462	18	sting	sting	NN
cord-275730-650sjwyy	462	19	in	in	IN
cord-275730-650sjwyy	462	20	the	the	DT
cord-275730-650sjwyy	462	21	tumor	tumor	NN
cord-275730-650sjwyy	462	22	microenvironment	microenvironment	NN
cord-275730-650sjwyy	462	23	via	via	IN
cord-275730-650sjwyy	462	24	cationic	cationic	JJ
cord-275730-650sjwyy	462	25	silica	silica	NN
cord-275730-650sjwyy	462	26	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	462	27	leading	lead	VBG
cord-275730-650sjwyy	462	28	to	to	IN
cord-275730-650sjwyy	462	29	enhanced	enhanced	JJ
cord-275730-650sjwyy	462	30	antitumor	antitumor	JJ
cord-275730-650sjwyy	462	31	immunity	immunity	NN
cord-275730-650sjwyy	462	32	An	an	DT
cord-275730-650sjwyy	462	33	inhalable	inhalable	JJ
cord-275730-650sjwyy	462	34	nanoparticulate	nanoparticulate	NN
cord-275730-650sjwyy	462	35	sting	sting	NN
cord-275730-650sjwyy	462	36	agonist	agonist	NN
cord-275730-650sjwyy	462	37	synergizes	synergize	VBZ
cord-275730-650sjwyy	462	38	with	with	IN
cord-275730-650sjwyy	462	39	radiotherapy	radiotherapy	NN
cord-275730-650sjwyy	462	40	to	to	TO
cord-275730-650sjwyy	462	41	confer	confer	VB
cord-275730-650sjwyy	462	42	long	long	JJ
cord-275730-650sjwyy	462	43	-	-	HYPH
cord-275730-650sjwyy	462	44	term	term	NN
cord-275730-650sjwyy	462	45	control	control	NN
cord-275730-650sjwyy	462	46	of	of	IN
cord-275730-650sjwyy	462	47	lung	lung	NN
cord-275730-650sjwyy	462	48	metastases	metastasis	NNS
cord-275730-650sjwyy	462	49	Sting	Sting	NNP
cord-275730-650sjwyy	462	50	pathway	pathway	NN
cord-275730-650sjwyy	462	51	activation	activation	NN
cord-275730-650sjwyy	462	52	stimulates	stimulate	VBZ
cord-275730-650sjwyy	462	53	potent	potent	JJ
cord-275730-650sjwyy	462	54	immunity	immunity	NN
cord-275730-650sjwyy	462	55	against	against	IN
cord-275730-650sjwyy	462	56	acute	acute	JJ
cord-275730-650sjwyy	462	57	myeloid	myeloid	NN
cord-275730-650sjwyy	462	58	leukemia	leukemia	NN
cord-275730-650sjwyy	463	1	Dmxaa	Dmxaa	NNP
cord-275730-650sjwyy	463	2	causes	cause	VBZ
cord-275730-650sjwyy	463	3	tumor	tumor	NN
cord-275730-650sjwyy	463	4	site	site	NN
cord-275730-650sjwyy	463	5	-	-	HYPH
cord-275730-650sjwyy	463	6	specific	specific	JJ
cord-275730-650sjwyy	463	7	vascular	vascular	JJ
cord-275730-650sjwyy	463	8	disruption	disruption	NN
cord-275730-650sjwyy	463	9	in	in	IN
cord-275730-650sjwyy	463	10	murine	murine	JJ
cord-275730-650sjwyy	463	11	non	non	JJ
cord-275730-650sjwyy	463	12	-	-	JJ
cord-275730-650sjwyy	463	13	small	small	JJ
cord-275730-650sjwyy	463	14	cell	cell	NN
cord-275730-650sjwyy	463	15	lung	lung	NN
cord-275730-650sjwyy	463	16	cancer	cancer	NN
cord-275730-650sjwyy	463	17	,	,	,
cord-275730-650sjwyy	463	18	and	and	CC
cord-275730-650sjwyy	463	19	like	like	IN
cord-275730-650sjwyy	463	20	the	the	DT
cord-275730-650sjwyy	463	21	endogenous	endogenous	JJ
cord-275730-650sjwyy	463	22	non	non	JJ
cord-275730-650sjwyy	463	23	-	-	JJ
cord-275730-650sjwyy	463	24	canonical	canonical	JJ
cord-275730-650sjwyy	463	25	cyclic	cyclic	JJ
cord-275730-650sjwyy	463	26	dinucleotide	dinucleotide	NN
cord-275730-650sjwyy	463	27	sting	sting	NN
cord-275730-650sjwyy	463	28	agonist	agonist	NN
cord-275730-650sjwyy	463	29	,	,	,
cord-275730-650sjwyy	463	30	2'3'-cgamp	2'3'-cgamp	CD
cord-275730-650sjwyy	463	31	,	,	,
cord-275730-650sjwyy	463	32	induces	induce	VBZ
cord-275730-650sjwyy	463	33	m2	m2	NNP
cord-275730-650sjwyy	463	34	macrophage	macrophage	NN
cord-275730-650sjwyy	463	35	repolarization	repolarization	NN
cord-275730-650sjwyy	463	36	A	a	DT
cord-275730-650sjwyy	463	37	robust	robust	JJ
cord-275730-650sjwyy	463	38	microparticle	microparticle	NNP
cord-275730-650sjwyy	463	39	platform	platform	NN
cord-275730-650sjwyy	463	40	for	for	IN
cord-275730-650sjwyy	463	41	a	a	DT
cord-275730-650sjwyy	463	42	sting	sting	NN
cord-275730-650sjwyy	463	43	-	-	HYPH
cord-275730-650sjwyy	463	44	targeted	target	VBN
cord-275730-650sjwyy	463	45	adjuvant	adjuvant	NN
cord-275730-650sjwyy	463	46	that	that	WDT
cord-275730-650sjwyy	463	47	enhances	enhance	VBZ
cord-275730-650sjwyy	463	48	both	both	DT
cord-275730-650sjwyy	463	49	humoral	humoral	JJ
cord-275730-650sjwyy	463	50	and	and	CC
cord-275730-650sjwyy	463	51	cellular	cellular	JJ
cord-275730-650sjwyy	463	52	immunity	immunity	NN
cord-275730-650sjwyy	463	53	during	during	IN
cord-275730-650sjwyy	463	54	vaccination	vaccination	NN
cord-275730-650sjwyy	463	55	Achieving	achieve	VBG
cord-275730-650sjwyy	463	56	long	long	JJ
cord-275730-650sjwyy	463	57	-	-	HYPH
cord-275730-650sjwyy	463	58	term	term	NN
cord-275730-650sjwyy	463	59	stability	stability	NN
cord-275730-650sjwyy	463	60	of	of	IN
cord-275730-650sjwyy	463	61	lipid	lipid	NN
cord-275730-650sjwyy	463	62	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	463	63	:	:	:
cord-275730-650sjwyy	463	64	Examining	examine	VBG
cord-275730-650sjwyy	463	65	the	the	DT
cord-275730-650sjwyy	463	66	effect	effect	NN
cord-275730-650sjwyy	463	67	of	of	IN
cord-275730-650sjwyy	463	68	ph	ph	NN
cord-275730-650sjwyy	463	69	,	,	,
cord-275730-650sjwyy	463	70	temperature	temperature	NN
cord-275730-650sjwyy	463	71	,	,	,
cord-275730-650sjwyy	463	72	and	and	CC
cord-275730-650sjwyy	463	73	lyophilization	lyophilization	NNP
cord-275730-650sjwyy	463	74	Short	Short	NNP
cord-275730-650sjwyy	463	75	-	-	HYPH
cord-275730-650sjwyy	463	76	and	and	CC
cord-275730-650sjwyy	463	77	long	long	JJ
cord-275730-650sjwyy	463	78	-	-	HYPH
cord-275730-650sjwyy	463	79	term	term	NN
cord-275730-650sjwyy	463	80	stability	stability	NN
cord-275730-650sjwyy	463	81	study	study	NN
cord-275730-650sjwyy	463	82	of	of	IN
cord-275730-650sjwyy	463	83	lyophilized	lyophilized	JJ
cord-275730-650sjwyy	463	84	solid	solid	JJ
cord-275730-650sjwyy	463	85	lipid	lipid	NN
cord-275730-650sjwyy	463	86	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	463	87	for	for	IN
cord-275730-650sjwyy	463	88	gene	gene	NN
cord-275730-650sjwyy	463	89	therapy	therapy	NN
cord-275730-650sjwyy	463	90	Safety	Safety	NNP
cord-275730-650sjwyy	463	91	of	of	IN
cord-275730-650sjwyy	463	92	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	463	93	in	in	IN
cord-275730-650sjwyy	463	94	medicine	medicine	NN
cord-275730-650sjwyy	463	95	Zinc	zinc	NN
cord-275730-650sjwyy	463	96	oxide	oxide	NN
cord-275730-650sjwyy	463	97	nanoparticles	nanoparticle	NNS
cord-275730-650sjwyy	463	98	:	:	:
cord-275730-650sjwyy	463	99	A	a	DT
cord-275730-650sjwyy	463	100	promising	promising	JJ
cord-275730-650sjwyy	463	101	nanomaterial	nanomaterial	NN
cord-275730-650sjwyy	463	102	for	for	IN
cord-275730-650sjwyy	463	103	biomedical	biomedical	JJ
cord-275730-650sjwyy	463	104	applications	application	NNS
cord-275730-650sjwyy	464	1	A	a	DT
cord-275730-650sjwyy	464	2	host	host	NN
cord-275730-650sjwyy	464	3	type	type	NN
cord-275730-650sjwyy	465	1	i	i	PRP
cord-275730-650sjwyy	466	1	interferon	interferon	NNP
cord-275730-650sjwyy	466	2	response	response	NN
cord-275730-650sjwyy	466	3	is	be	VBZ
cord-275730-650sjwyy	466	4	induced	induce	VBN
cord-275730-650sjwyy	466	5	by	by	IN
cord-275730-650sjwyy	466	6	cytosolic	cytosolic	JJ
cord-275730-650sjwyy	466	7	sensing	sensing	NN
cord-275730-650sjwyy	466	8	of	of	IN
cord-275730-650sjwyy	466	9	the	the	DT
cord-275730-650sjwyy	466	10	bacterial	bacterial	JJ
cord-275730-650sjwyy	466	11	second	second	JJ
cord-275730-650sjwyy	466	12	messenger	messenger	NN
cord-275730-650sjwyy	466	13	cyclic	cyclic	JJ
cord-275730-650sjwyy	466	14	-	-	HYPH
cord-275730-650sjwyy	466	15	di	di	FW
cord-275730-650sjwyy	466	16	-	-	HYPH
cord-275730-650sjwyy	466	17	gmp	gmp	NNP
cord-275730-650sjwyy	467	1	The	the	DT
cord-275730-650sjwyy	467	2	n	n	JJ
cord-275730-650sjwyy	467	3	-	-	HYPH
cord-275730-650sjwyy	467	4	ethyl	ethyl	NNP
cord-275730-650sjwyy	467	5	-	-	HYPH
cord-275730-650sjwyy	467	6	n	n	NN
cord-275730-650sjwyy	467	7	-	-	HYPH
cord-275730-650sjwyy	467	8	nitrosourea	nitrosourea	NN
cord-275730-650sjwyy	467	9	-	-	HYPH
cord-275730-650sjwyy	467	10	induced	induce	VBN
cord-275730-650sjwyy	467	11	goldenticket	goldenticket	NN
cord-275730-650sjwyy	467	12	mouse	mouse	NN
cord-275730-650sjwyy	467	13	mutant	mutant	NN
cord-275730-650sjwyy	467	14	reveals	reveal	VBZ
cord-275730-650sjwyy	467	15	an	an	DT
cord-275730-650sjwyy	467	16	essential	essential	JJ
cord-275730-650sjwyy	467	17	function	function	NN
cord-275730-650sjwyy	467	18	of	of	IN
cord-275730-650sjwyy	467	19	sting	sting	NN
cord-275730-650sjwyy	467	20	in	in	IN
cord-275730-650sjwyy	467	21	the	the	DT
cord-275730-650sjwyy	467	22	in	in	IN
cord-275730-650sjwyy	467	23	vivo	vivo	FW
cord-275730-650sjwyy	467	24	interferon	interferon	NN
cord-275730-650sjwyy	467	25	response	response	NN
cord-275730-650sjwyy	467	26	to	to	IN
cord-275730-650sjwyy	467	27	listeria	listeria	NNP
cord-275730-650sjwyy	467	28	monocytogenes	monocytogenes	NNP
cord-275730-650sjwyy	467	29	and	and	CC
cord-275730-650sjwyy	468	1	cyclic	cyclic	JJ
cord-275730-650sjwyy	468	2	dinucleotides	dinucleotide	VBZ
cord-275730-650sjwyy	468	3	Mpys	Mpys	NNP
cord-275730-650sjwyy	468	4	is	be	VBZ
cord-275730-650sjwyy	468	5	required	require	VBN
cord-275730-650sjwyy	468	6	for	for	IN
cord-275730-650sjwyy	468	7	ifn	ifn	NNP
cord-275730-650sjwyy	468	8	response	response	NN
cord-275730-650sjwyy	468	9	factor	factor	NN
cord-275730-650sjwyy	468	10	3	3	CD
cord-275730-650sjwyy	468	11	activation	activation	NN
cord-275730-650sjwyy	468	12	and	and	CC
cord-275730-650sjwyy	468	13	type	type	NN
cord-275730-650sjwyy	469	1	i	i	PRP
cord-275730-650sjwyy	469	2	ifn	ifn	NNP
cord-275730-650sjwyy	469	3	production	production	NN
cord-275730-650sjwyy	469	4	in	in	IN
cord-275730-650sjwyy	469	5	the	the	DT
cord-275730-650sjwyy	469	6	response	response	NN
cord-275730-650sjwyy	469	7	of	of	IN
cord-275730-650sjwyy	469	8	cultured	cultured	JJ
cord-275730-650sjwyy	469	9	phagocytes	phagocyte	NNS
cord-275730-650sjwyy	469	10	to	to	TO
cord-275730-650sjwyy	469	11	bacterial	bacterial	JJ
cord-275730-650sjwyy	469	12	second	second	JJ
cord-275730-650sjwyy	469	13	messengers	messenger	NNS
cord-275730-650sjwyy	469	14	cyclic	cyclic	JJ
cord-275730-650sjwyy	469	15	-	-	HYPH
cord-275730-650sjwyy	469	16	di	di	NN
cord-275730-650sjwyy	469	17	-	-	HYPH
cord-275730-650sjwyy	469	18	amp	amp	NN
cord-275730-650sjwyy	469	19	and	and	CC
cord-275730-650sjwyy	469	20	cyclic	cyclic	JJ
cord-275730-650sjwyy	469	21	-	-	HYPH
cord-275730-650sjwyy	469	22	di	di	FW
cord-275730-650sjwyy	469	23	-	-	HYPH
cord-275730-650sjwyy	469	24	gmp	gmp	NNP
cord-275730-650sjwyy	469	25	Immature	immature	JJ
cord-275730-650sjwyy	469	26	lung	lung	NN
cord-275730-650sjwyy	469	27	tnfr2(-	tnfr2(-	NNS
cord-275730-650sjwyy	469	28	)	)	-RRB-
cord-275730-650sjwyy	470	1	conventional	conventional	JJ
cord-275730-650sjwyy	470	2	dc	dc	NNP
cord-275730-650sjwyy	470	3	2	2	CD
cord-275730-650sjwyy	470	4	subpopulation	subpopulation	NN
cord-275730-650sjwyy	470	5	activates	activate	VBZ
cord-275730-650sjwyy	470	6	modcs	modcs	NNP
cord-275730-650sjwyy	470	7	to	to	TO
cord-275730-650sjwyy	470	8	promote	promote	VB
cord-275730-650sjwyy	470	9	cyclic	cyclic	JJ
cord-275730-650sjwyy	470	10	di	di	FW
cord-275730-650sjwyy	470	11	-	-	HYPH
cord-275730-650sjwyy	470	12	gmp	gmp	NNP
cord-275730-650sjwyy	470	13	mucosal	mucosal	NN
cord-275730-650sjwyy	470	14	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	470	15	responses	response	NNS
cord-275730-650sjwyy	470	16	in	in	IN
cord-275730-650sjwyy	470	17	vivo	vivo	NNP
cord-275730-650sjwyy	470	18	Mucosal	Mucosal	NNP
cord-275730-650sjwyy	470	19	vaccine	vaccine	NN
cord-275730-650sjwyy	471	1	adjuvant	adjuvant	JJ
cord-275730-650sjwyy	471	2	cyclic	cyclic	NN
cord-275730-650sjwyy	471	3	di	di	NNP
cord-275730-650sjwyy	471	4	-	-	HYPH
cord-275730-650sjwyy	471	5	GMP	GMP	NNP
cord-275730-650sjwyy	471	6	differentiates	differentiate	VBZ
cord-275730-650sjwyy	471	7	lung	lung	NN
cord-275730-650sjwyy	471	8	moDCs	modcs	NN
cord-275730-650sjwyy	471	9	into	into	IN
cord-275730-650sjwyy	471	10	Bcl6	Bcl6	NNP
cord-275730-650sjwyy	471	11	+	+	CC
cord-275730-650sjwyy	471	12	and	and	CC
cord-275730-650sjwyy	471	13	Bcl6	Bcl6	NNP
cord-275730-650sjwyy	471	14	−	−	NNP
cord-275730-650sjwyy	471	15	mature	mature	VBP
cord-275730-650sjwyy	471	16	moDCs	moDCs	NNP
cord-275730-650sjwyy	471	17	to	to	TO
cord-275730-650sjwyy	471	18	induce	induce	VB
cord-275730-650sjwyy	471	19	lung	lung	NN
cord-275730-650sjwyy	471	20	memory	memory	NN
cord-275730-650sjwyy	471	21	CD4	CD4	NNP
cord-275730-650sjwyy	471	22	+	+	CC
cord-275730-650sjwyy	471	23	T	T	NNP
cord-275730-650sjwyy	471	24	H	h	NN
cord-275730-650sjwyy	471	25	cells	cell	NNS
cord-275730-650sjwyy	471	26	and	and	CC
cord-275730-650sjwyy	471	27	lung	lung	NN
cord-275730-650sjwyy	471	28	T	T	NNP
cord-275730-650sjwyy	471	29	FH	FH	NNP
cord-275730-650sjwyy	471	30	cells	cell	NNS
cord-275730-650sjwyy	472	1	respectively	respectively	RB
cord-275730-650sjwyy	472	2	Sting	Sting	NNP
cord-275730-650sjwyy	472	3	activation	activation	NN
cord-275730-650sjwyy	472	4	reprograms	reprogram	VBZ
cord-275730-650sjwyy	472	5	tumor	tumor	NN
cord-275730-650sjwyy	472	6	vasculatures	vasculature	NNS
cord-275730-650sjwyy	472	7	and	and	CC
cord-275730-650sjwyy	472	8	synergizes	synergize	VBZ
cord-275730-650sjwyy	472	9	with	with	IN
cord-275730-650sjwyy	472	10	vegfr2	vegfr2	NN
cord-275730-650sjwyy	472	11	blockade	blockade	NN
cord-275730-650sjwyy	472	12	Sting	sting	NN
cord-275730-650sjwyy	472	13	-	-	HYPH
cord-275730-650sjwyy	472	14	dependent	dependent	JJ
cord-275730-650sjwyy	472	15	cytosolic	cytosolic	JJ
cord-275730-650sjwyy	472	16	DNA	dna	NN
cord-275730-650sjwyy	472	17	sensing	sensing	NN
cord-275730-650sjwyy	472	18	promotes	promote	VBZ
cord-275730-650sjwyy	472	19	radiation	radiation	NN
cord-275730-650sjwyy	472	20	-	-	HYPH
cord-275730-650sjwyy	472	21	induced	induce	VBN
cord-275730-650sjwyy	472	22	type	type	NN
cord-275730-650sjwyy	473	1	i	i	PRP
cord-275730-650sjwyy	473	2	interferon	interferon	NN
cord-275730-650sjwyy	473	3	-	-	HYPH
cord-275730-650sjwyy	473	4	dependent	dependent	JJ
cord-275730-650sjwyy	473	5	antitumor	antitumor	JJ
cord-275730-650sjwyy	473	6	immunity	immunity	NN
cord-275730-650sjwyy	473	7	in	in	IN
cord-275730-650sjwyy	473	8	immunogenic	immunogenic	JJ
cord-275730-650sjwyy	473	9	tumors	tumor	NNS
cord-275730-650sjwyy	474	1	The	the	DT
cord-275730-650sjwyy	474	2	host	host	NN
cord-275730-650sjwyy	474	3	sting	sting	NN
cord-275730-650sjwyy	474	4	pathway	pathway	NN
cord-275730-650sjwyy	474	5	at	at	IN
cord-275730-650sjwyy	474	6	the	the	DT
cord-275730-650sjwyy	474	7	interface	interface	NN
cord-275730-650sjwyy	474	8	of	of	IN
cord-275730-650sjwyy	474	9	cancer	cancer	NN
cord-275730-650sjwyy	474	10	and	and	CC
cord-275730-650sjwyy	474	11	immunity	immunity	NN
cord-275730-650sjwyy	474	12	Sting	Sting	NNP
cord-275730-650sjwyy	474	13	pathway	pathway	NN
cord-275730-650sjwyy	474	14	agonism	agonism	NN
cord-275730-650sjwyy	474	15	as	as	IN
cord-275730-650sjwyy	474	16	a	a	DT
cord-275730-650sjwyy	474	17	cancer	cancer	NN
cord-275730-650sjwyy	474	18	therapeutic	therapeutic	JJ
cord-275730-650sjwyy	474	19	Type	type	NN
cord-275730-650sjwyy	474	20	i	i	PRP
cord-275730-650sjwyy	474	21	ifn	ifn	NNP
cord-275730-650sjwyy	474	22	and	and	CC
cord-275730-650sjwyy	474	23	not	not	RB
cord-275730-650sjwyy	474	24	tnf	tnf	NNP
cord-275730-650sjwyy	474	25	,	,	,
cord-275730-650sjwyy	474	26	is	be	VBZ
cord-275730-650sjwyy	474	27	essential	essential	JJ
cord-275730-650sjwyy	474	28	for	for	IN
cord-275730-650sjwyy	474	29	cyclic	cyclic	JJ
cord-275730-650sjwyy	474	30	di	di	FW
cord-275730-650sjwyy	474	31	-	-	HYPH
cord-275730-650sjwyy	474	32	nucleotide	nucleotide	RB
cord-275730-650sjwyy	474	33	-	-	HYPH
cord-275730-650sjwyy	474	34	elicited	elicit	VBN
cord-275730-650sjwyy	474	35	ctl	ctl	NN
cord-275730-650sjwyy	474	36	by	by	IN
cord-275730-650sjwyy	474	37	a	a	DT
cord-275730-650sjwyy	474	38	cytosolic	cytosolic	JJ
cord-275730-650sjwyy	474	39	cross	cross	JJ
cord-275730-650sjwyy	474	40	-	-	JJ
cord-275730-650sjwyy	474	41	presentation	presentation	JJ
cord-275730-650sjwyy	474	42	pathway	pathway	NN
cord-275730-650sjwyy	474	43	Growing	grow	VBG
cord-275730-650sjwyy	474	44	tumors	tumor	NNS
cord-275730-650sjwyy	474	45	induce	induce	VBP
cord-275730-650sjwyy	474	46	a	a	DT
cord-275730-650sjwyy	474	47	local	local	JJ
cord-275730-650sjwyy	474	48	sting	sting	NN
cord-275730-650sjwyy	474	49	dependent	dependent	JJ
cord-275730-650sjwyy	474	50	type	type	NN
cord-275730-650sjwyy	475	1	i	i	PRP
cord-275730-650sjwyy	475	2	ifn	ifn	NNP
cord-275730-650sjwyy	475	3	response	response	NN
cord-275730-650sjwyy	475	4	in	in	IN
cord-275730-650sjwyy	475	5	dendritic	dendritic	JJ
cord-275730-650sjwyy	475	6	cells	cell	NNS
cord-275730-650sjwyy	475	7	Sting	Sting	NNP
cord-275730-650sjwyy	475	8	and	and	CC
cord-275730-650sjwyy	475	9	irf3	irf3	NN
cord-275730-650sjwyy	475	10	in	in	IN
cord-275730-650sjwyy	475	11	stromal	stromal	JJ
cord-275730-650sjwyy	475	12	fibroblasts	fibroblast	NNS
cord-275730-650sjwyy	475	13	enable	enable	VBP
cord-275730-650sjwyy	475	14	sensing	sensing	NN
cord-275730-650sjwyy	475	15	of	of	IN
cord-275730-650sjwyy	475	16	genomic	genomic	JJ
cord-275730-650sjwyy	475	17	stress	stress	NN
cord-275730-650sjwyy	475	18	in	in	IN
cord-275730-650sjwyy	475	19	cancer	cancer	NN
cord-275730-650sjwyy	475	20	cells	cell	NNS
cord-275730-650sjwyy	475	21	to	to	TO
cord-275730-650sjwyy	475	22	undermine	undermine	VB
cord-275730-650sjwyy	475	23	oncolytic	oncolytic	JJ
cord-275730-650sjwyy	475	24	viral	viral	JJ
cord-275730-650sjwyy	475	25	therapy	therapy	NN
cord-275730-650sjwyy	476	1	Tumor	tumor	NN
cord-275730-650sjwyy	476	2	-	-	HYPH
cord-275730-650sjwyy	476	3	derived	derive	VBN
cord-275730-650sjwyy	476	4	cgamp	cgamp	NN
cord-275730-650sjwyy	476	5	triggers	trigger	NNS
cord-275730-650sjwyy	477	1	a	a	DT
cord-275730-650sjwyy	477	2	sting	sting	NN
cord-275730-650sjwyy	477	3	-	-	HYPH
cord-275730-650sjwyy	477	4	mediated	mediate	VBN
cord-275730-650sjwyy	477	5	interferon	interferon	NN
cord-275730-650sjwyy	477	6	response	response	NN
cord-275730-650sjwyy	477	7	in	in	IN
cord-275730-650sjwyy	477	8	non	non	JJ
cord-275730-650sjwyy	477	9	-	-	JJ
cord-275730-650sjwyy	477	10	tumor	tumor	JJ
cord-275730-650sjwyy	477	11	cells	cell	NNS
cord-275730-650sjwyy	477	12	to	to	TO
cord-275730-650sjwyy	477	13	activate	activate	VB
cord-275730-650sjwyy	477	14	the	the	DT
cord-275730-650sjwyy	477	15	nk	nk	NNP
cord-275730-650sjwyy	477	16	cell	cell	NN
cord-275730-650sjwyy	477	17	response	response	NN
cord-275730-650sjwyy	477	18	Identification	identification	NN
cord-275730-650sjwyy	477	19	and	and	CC
cord-275730-650sjwyy	477	20	characterization	characterization	NN
cord-275730-650sjwyy	477	21	of	of	IN
cord-275730-650sjwyy	477	22	a	a	DT
cord-275730-650sjwyy	477	23	loss	loss	NN
cord-275730-650sjwyy	477	24	-	-	HYPH
cord-275730-650sjwyy	477	25	of	of	IN
cord-275730-650sjwyy	477	26	-	-	HYPH
cord-275730-650sjwyy	477	27	function	function	NN
cord-275730-650sjwyy	477	28	human	human	JJ
cord-275730-650sjwyy	477	29	mpys	mpys	NN
cord-275730-650sjwyy	477	30	variant	variant	NN
cord-275730-650sjwyy	477	31	Tmem173	tmem173	NN
cord-275730-650sjwyy	477	32	variants	variant	NNS
cord-275730-650sjwyy	477	33	and	and	CC
cord-275730-650sjwyy	477	34	potential	potential	JJ
cord-275730-650sjwyy	477	35	importance	importance	NN
cord-275730-650sjwyy	477	36	to	to	IN
cord-275730-650sjwyy	477	37	human	human	JJ
cord-275730-650sjwyy	477	38	biology	biology	NN
cord-275730-650sjwyy	477	39	and	and	CC
cord-275730-650sjwyy	477	40	disease	disease	NN
cord-275730-650sjwyy	477	41	Response	response	NN
cord-275730-650sjwyy	477	42	to	to	TO
cord-275730-650sjwyy	477	43	comment	comment	VB
cord-275730-650sjwyy	477	44	on	on	IN
cord-275730-650sjwyy	477	45	"	"	``
cord-275730-650sjwyy	477	46	the	the	DT
cord-275730-650sjwyy	477	47	common	common	JJ
cord-275730-650sjwyy	477	48	r71h	r71h	NNPS
cord-275730-650sjwyy	477	49	-	-	HYPH
cord-275730-650sjwyy	477	50	g230a	g230a	CD
cord-275730-650sjwyy	477	51	-	-	HYPH
cord-275730-650sjwyy	477	52	r293q	r293q	CD
cord-275730-650sjwyy	477	53	human	human	JJ
cord-275730-650sjwyy	477	54	tmem173	tmem173	NN
cord-275730-650sjwyy	477	55	is	be	VBZ
cord-275730-650sjwyy	477	56	a	a	DT
cord-275730-650sjwyy	477	57	null	null	JJ
cord-275730-650sjwyy	477	58	allele	allele	NN
cord-275730-650sjwyy	477	59	Obesity	obesity	NN
cord-275730-650sjwyy	477	60	and	and	CC
cord-275730-650sjwyy	477	61	sting1	sting1	NN
cord-275730-650sjwyy	477	62	genotype	genotype	NN
cord-275730-650sjwyy	477	63	associate	associate	NN
cord-275730-650sjwyy	477	64	with	with	IN
cord-275730-650sjwyy	477	65	23-valent	23-valent	CD
cord-275730-650sjwyy	477	66	pneumococcal	pneumococcal	JJ
cord-275730-650sjwyy	477	67	vaccination	vaccination	NN
cord-275730-650sjwyy	477	68	efficacy	efficacy	NN
cord-275730-650sjwyy	478	1	Polymorphisms	polymorphism	NNS
cord-275730-650sjwyy	478	2	in	in	IN
cord-275730-650sjwyy	478	3	sting	sting	NN
cord-275730-650sjwyy	478	4	affect	affect	VBP
cord-275730-650sjwyy	478	5	human	human	JJ
cord-275730-650sjwyy	478	6	innate	innate	JJ
cord-275730-650sjwyy	478	7	immune	immune	JJ
cord-275730-650sjwyy	478	8	responses	response	NNS
cord-275730-650sjwyy	478	9	to	to	IN
cord-275730-650sjwyy	478	10	poxviruses	poxvirus	NNS
cord-275730-650sjwyy	478	11	Single	single	JJ
cord-275730-650sjwyy	478	12	nucleotide	nucleotide	JJ
cord-275730-650sjwyy	478	13	polymorphisms	polymorphism	NNS
cord-275730-650sjwyy	478	14	of	of	IN
cord-275730-650sjwyy	478	15	human	human	JJ
cord-275730-650sjwyy	478	16	sting	sting	NN
cord-275730-650sjwyy	478	17	can	can	MD
cord-275730-650sjwyy	478	18	affect	affect	VB
cord-275730-650sjwyy	478	19	innate	innate	JJ
cord-275730-650sjwyy	478	20	immune	immune	JJ
cord-275730-650sjwyy	478	21	response	response	NN
cord-275730-650sjwyy	478	22	to	to	IN
cord-275730-650sjwyy	478	23	cyclic	cyclic	JJ
cord-275730-650sjwyy	478	24	dinucleotides	dinucleotide	NNS
cord-275730-650sjwyy	478	25	Sting	Sting	NNP
cord-275730-650sjwyy	478	26	pathway	pathway	NN
cord-275730-650sjwyy	478	27	stimulation	stimulation	NN
cord-275730-650sjwyy	478	28	results	result	NNS
cord-275730-650sjwyy	478	29	in	in	IN
cord-275730-650sjwyy	478	30	a	a	DT
cord-275730-650sjwyy	478	31	differentially	differentially	RB
cord-275730-650sjwyy	478	32	activated	activate	VBN
cord-275730-650sjwyy	478	33	innate	innate	JJ
cord-275730-650sjwyy	478	34	immune	immune	JJ
cord-275730-650sjwyy	478	35	phenotype	phenotype	NN
cord-275730-650sjwyy	478	36	associated	associate	VBN
cord-275730-650sjwyy	478	37	with	with	IN
cord-275730-650sjwyy	478	38	low	low	JJ
cord-275730-650sjwyy	478	39	nitric	nitric	NN
cord-275730-650sjwyy	478	40	oxide	oxide	NN
cord-275730-650sjwyy	478	41	and	and	CC
cord-275730-650sjwyy	478	42	enhanced	enhanced	JJ
cord-275730-650sjwyy	478	43	antibody	antibody	NN
cord-275730-650sjwyy	478	44	titers	titer	NNS
cord-275730-650sjwyy	478	45	in	in	IN
cord-275730-650sjwyy	479	1	young	young	JJ
cord-275730-650sjwyy	479	2	and	and	CC
cord-275730-650sjwyy	479	3	aged	aged	JJ
cord-275730-650sjwyy	479	4	mice	mouse	NNS
cord-275730-650sjwyy	479	5	Combination	Combination	NNP
cord-275730-650sjwyy	479	6	of	of	IN
cord-275730-650sjwyy	479	7	sting	sting	NN
cord-275730-650sjwyy	479	8	pathway	pathway	NN
cord-275730-650sjwyy	479	9	agonist	agonist	NN
cord-275730-650sjwyy	479	10	with	with	IN
cord-275730-650sjwyy	479	11	saponin	saponin	NN
cord-275730-650sjwyy	479	12	is	be	VBZ
cord-275730-650sjwyy	479	13	an	an	DT
cord-275730-650sjwyy	479	14	effective	effective	JJ
cord-275730-650sjwyy	479	15	adjuvant	adjuvant	NN
cord-275730-650sjwyy	479	16	in	in	IN
cord-275730-650sjwyy	479	17	immunosenescent	immunosenescent	NNP
cord-275730-650sjwyy	479	18	mice	mouse	NNS
cord-275730-650sjwyy	480	1	New	new	JJ
cord-275730-650sjwyy	480	2	modc	modc	RB
cord-275730-650sjwyy	480	3	-	-	HYPH
cord-275730-650sjwyy	480	4	targeting	target	VBG
cord-275730-650sjwyy	480	5	tnf	tnf	NNP
cord-275730-650sjwyy	480	6	fusion	fusion	NN
cord-275730-650sjwyy	480	7	proteins	protein	NNS
cord-275730-650sjwyy	480	8	enhance	enhance	VBP
cord-275730-650sjwyy	480	9	cyclic	cyclic	JJ
cord-275730-650sjwyy	480	10	di	di	FW
cord-275730-650sjwyy	480	11	-	-	HYPH
cord-275730-650sjwyy	480	12	gmp	gmp	NNP
cord-275730-650sjwyy	480	13	vaccine	vaccine	NN
cord-275730-650sjwyy	480	14	adjuvanticity	adjuvanticity	NN
cord-275730-650sjwyy	480	15	in	in	IN
cord-275730-650sjwyy	480	16	middle	middle	NN
cord-275730-650sjwyy	480	17	-	-	HYPH
cord-275730-650sjwyy	480	18	aged	aged	JJ
cord-275730-650sjwyy	480	19	and	and	CC
cord-275730-650sjwyy	480	20	aged	aged	JJ
cord-275730-650sjwyy	480	21	mice	mouse	NNS
cord-275730-650sjwyy	480	22	Immunosenescence	Immunosenescence	NNP
cord-275730-650sjwyy	480	23	and	and	CC
cord-275730-650sjwyy	480	24	vaccine	vaccine	NN
cord-275730-650sjwyy	480	25	failure	failure	NN
cord-275730-650sjwyy	480	26	in	in	IN
cord-275730-650sjwyy	480	27	the	the	DT
cord-275730-650sjwyy	480	28	elderly	elderly	JJ
cord-275730-650sjwyy	480	29	:	:	:
cord-275730-650sjwyy	480	30	Strategies	strategy	NNS
cord-275730-650sjwyy	480	31	for	for	IN
cord-275730-650sjwyy	480	32	improving	improve	VBG
cord-275730-650sjwyy	480	33	response	response	NN
cord-275730-650sjwyy	480	34	Age	Age	NNP
cord-275730-650sjwyy	480	35	-	-	HYPH
cord-275730-650sjwyy	480	36	related	relate	VBN
cord-275730-650sjwyy	480	37	defects	defect	NNS
cord-275730-650sjwyy	480	38	in	in	IN
cord-275730-650sjwyy	480	39	cd4	cd4	NNP
cord-275730-650sjwyy	480	40	t	t	NNP
cord-275730-650sjwyy	480	41	cell	cell	NN
cord-275730-650sjwyy	480	42	cognate	cognate	JJ
cord-275730-650sjwyy	480	43	helper	helper	NN
cord-275730-650sjwyy	480	44	function	function	NN
cord-275730-650sjwyy	480	45	lead	lead	VB
cord-275730-650sjwyy	480	46	to	to	IN
cord-275730-650sjwyy	480	47	reductions	reduction	NNS
cord-275730-650sjwyy	480	48	in	in	IN
cord-275730-650sjwyy	480	49	humoral	humoral	JJ
cord-275730-650sjwyy	480	50	responses	response	NNS
cord-275730-650sjwyy	480	51	Cd4	cd4	NN
cord-275730-650sjwyy	480	52	+	+	CC
cord-275730-650sjwyy	480	53	t	t	NN
cord-275730-650sjwyy	480	54	cells	cell	NNS
cord-275730-650sjwyy	480	55	and	and	CC
cord-275730-650sjwyy	480	56	immunosenescence	immunosenescence	NN
cord-275730-650sjwyy	480	57	-	-	HYPH
cord-275730-650sjwyy	480	58	A	a	DT
cord-275730-650sjwyy	480	59	mini	mini	JJ
cord-275730-650sjwyy	480	60	-	-	NN
cord-275730-650sjwyy	480	61	review	review	NN
cord-275730-650sjwyy	480	62	Aging	aging	NN
cord-275730-650sjwyy	480	63	of	of	IN
cord-275730-650sjwyy	480	64	the	the	DT
cord-275730-650sjwyy	480	65	cd4	cd4	NNP
cord-275730-650sjwyy	480	66	t	t	NNP
cord-275730-650sjwyy	480	67	cell	cell	NNP
cord-275730-650sjwyy	480	68	compartment	compartment	NNP
cord-275730-650sjwyy	481	1	The	the	DT
cord-275730-650sjwyy	481	2	common	common	JJ
cord-275730-650sjwyy	481	3	haq	haq	NNP
cord-275730-650sjwyy	481	4	sting	sting	NN
cord-275730-650sjwyy	481	5	variant	variant	NN
cord-275730-650sjwyy	481	6	impairs	impair	VBZ
cord-275730-650sjwyy	481	7	cgas	cgas	NN
cord-275730-650sjwyy	481	8	-	-	HYPH
cord-275730-650sjwyy	481	9	dependent	dependent	JJ
cord-275730-650sjwyy	481	10	antibacterial	antibacterial	JJ
cord-275730-650sjwyy	481	11	responses	response	NNS
cord-275730-650sjwyy	481	12	and	and	CC
cord-275730-650sjwyy	481	13	is	be	VBZ
cord-275730-650sjwyy	481	14	associated	associate	VBN
cord-275730-650sjwyy	481	15	with	with	IN
cord-275730-650sjwyy	481	16	susceptibility	susceptibility	NN
cord-275730-650sjwyy	481	17	to	to	IN
cord-275730-650sjwyy	481	18	legionnaires	legionnaire	NNS
cord-275730-650sjwyy	481	19	'	'	POS
cord-275730-650sjwyy	481	20	disease	disease	NN
cord-275730-650sjwyy	481	21	in	in	IN
cord-275730-650sjwyy	481	22	humans	human	NNS
cord-275730-650sjwyy	482	1	Multiple	multiple	JJ
cord-275730-650sjwyy	482	2	homozygous	homozygous	JJ
cord-275730-650sjwyy	482	3	variants	variant	NNS
cord-275730-650sjwyy	482	4	in	in	IN
cord-275730-650sjwyy	482	5	the	the	DT
cord-275730-650sjwyy	482	6	sting	sting	NN
cord-275730-650sjwyy	482	7	-	-	HYPH
cord-275730-650sjwyy	482	8	encoding	encode	VBG
cord-275730-650sjwyy	482	9	tmem173	tmem173	NN
cord-275730-650sjwyy	482	10	gene	gene	NN
cord-275730-650sjwyy	482	11	in	in	IN
cord-275730-650sjwyy	482	12	hiv	hiv	NNP
cord-275730-650sjwyy	482	13	long	long	JJ
cord-275730-650sjwyy	482	14	-	-	HYPH
cord-275730-650sjwyy	482	15	term	term	NN
cord-275730-650sjwyy	482	16	nonprogressors	nonprogressor	NNS
cord-275730-650sjwyy	482	17	Sting	Sting	NNP
cord-275730-650sjwyy	482	18	differentially	differentially	RB
cord-275730-650sjwyy	482	19	regulates	regulate	VBZ
cord-275730-650sjwyy	482	20	experimental	experimental	JJ
cord-275730-650sjwyy	482	21	gvhd	gvhd	NN
cord-275730-650sjwyy	482	22	mediated	mediate	VBN
cord-275730-650sjwyy	482	23	by	by	IN
cord-275730-650sjwyy	482	24	cd8	cd8	NNS
cord-275730-650sjwyy	482	25	versus	versus	IN
cord-275730-650sjwyy	482	26	cd4	cd4	NNP
cord-275730-650sjwyy	482	27	t	t	NNP
cord-275730-650sjwyy	482	28	cell	cell	NN
cord-275730-650sjwyy	482	29	subsets	subset	NNS
cord-275730-650sjwyy	483	1	Self	self	NN
cord-275730-650sjwyy	483	2	-	-	HYPH
cord-275730-650sjwyy	483	3	assembled	assemble	VBN
cord-275730-650sjwyy	483	4	cgamp	cgamp	NN
cord-275730-650sjwyy	483	5	-	-	HYPH
cord-275730-650sjwyy	483	6	stingdeltatm	stingdeltatm	NN
cord-275730-650sjwyy	483	7	signaling	signal	VBG
cord-275730-650sjwyy	483	8	complex	complex	JJ
cord-275730-650sjwyy	483	9	as	as	IN
cord-275730-650sjwyy	483	10	a	a	DT
cord-275730-650sjwyy	483	11	bioinspired	bioinspired	JJ
cord-275730-650sjwyy	483	12	platform	platform	NN
cord-275730-650sjwyy	483	13	for	for	IN
cord-275730-650sjwyy	483	14	cgamp	cgamp	NN
cord-275730-650sjwyy	483	15	delivery	delivery	NN
cord-275730-650sjwyy	484	1	This	this	DT
cord-275730-650sjwyy	484	2	article	article	NN
cord-275730-650sjwyy	484	3	is	be	VBZ
cord-275730-650sjwyy	484	4	an	an	DT
cord-275730-650sjwyy	484	5	open	open	JJ
cord-275730-650sjwyy	484	6	access	access	NN
cord-275730-650sjwyy	484	7	article	article	NN
cord-275730-650sjwyy	484	8	distributed	distribute	VBN
cord-275730-650sjwyy	484	9	under	under	IN
cord-275730-650sjwyy	484	10	the	the	DT
cord-275730-650sjwyy	484	11	terms	term	NNS
cord-275730-650sjwyy	484	12	and	and	CC
cord-275730-650sjwyy	484	13	conditions	condition	NNS
cord-275730-650sjwyy	484	14	of	of	IN
cord-275730-650sjwyy	484	15	the	the	DT
cord-275730-650sjwyy	484	16	Creative	Creative	NNP
cord-275730-650sjwyy	484	17	Commons	Commons	NNP
cord-275730-650sjwyy	484	18	Attribution	Attribution	NNP
cord-275730-650sjwyy	484	19	(	(	-LRB-
cord-275730-650sjwyy	484	20	CC	CC	NNP
cord-275730-650sjwyy	484	21	BY	by	IN
cord-275730-650sjwyy	484	22	)	)	-RRB-
cord-275730-650sjwyy	484	23	license	license	NN
cord-275730-650sjwyy	485	1	The	the	DT
cord-275730-650sjwyy	485	2	authors	author	NNS
cord-275730-650sjwyy	485	3	declare	declare	VBP
cord-275730-650sjwyy	485	4	no	no	DT
cord-275730-650sjwyy	485	5	conflict	conflict	NN
cord-275730-650sjwyy	485	6	of	of	IN
cord-275730-650sjwyy	485	7	interest	interest	NN
cord-275730-650sjwyy	485	8	.	.	.