id	sid	tid	token	lemma	pos
cord-336510-qzm9wgde	1	1	key	key	NN
cord-336510-qzm9wgde	1	2	:	:	:
cord-336510-qzm9wgde	1	3	cord-336510-qzm9wgde	cord-336510-qzm9wgde	NNP
cord-336510-qzm9wgde	1	4	authors	author	NNS
cord-336510-qzm9wgde	1	5	:	:	:
cord-336510-qzm9wgde	1	6	Ellermann	Ellermann	NNP
cord-336510-qzm9wgde	1	7	-	-	HYPH
cord-336510-qzm9wgde	1	8	Eriksen	Eriksen	NNP
cord-336510-qzm9wgde	1	9	,	,	,
cord-336510-qzm9wgde	2	1	Svend	Svend	NNP
cord-336510-qzm9wgde	2	2	title	title	NN
cord-336510-qzm9wgde	2	3	:	:	:
cord-336510-qzm9wgde	2	4	Macrophages	macrophage	NNS
cord-336510-qzm9wgde	2	5	and	and	CC
cord-336510-qzm9wgde	2	6	cytokines	cytokine	NNS
cord-336510-qzm9wgde	2	7	in	in	IN
cord-336510-qzm9wgde	2	8	the	the	DT
cord-336510-qzm9wgde	2	9	early	early	JJ
cord-336510-qzm9wgde	2	10	defence	defence	NN
cord-336510-qzm9wgde	2	11	against	against	IN
cord-336510-qzm9wgde	2	12	herpes	herpes	NNP
cord-336510-qzm9wgde	2	13	simplex	simplex	NNP
cord-336510-qzm9wgde	2	14	virus	virus	NN
cord-336510-qzm9wgde	2	15	date	date	NN
cord-336510-qzm9wgde	2	16	:	:	:
cord-336510-qzm9wgde	2	17	2005	2005	CD
cord-336510-qzm9wgde	2	18	-	-	HYPH
cord-336510-qzm9wgde	2	19	08	08	CD
cord-336510-qzm9wgde	2	20	-	-	HYPH
cord-336510-qzm9wgde	2	21	03	03	CD
cord-336510-qzm9wgde	2	22	journal	journal	NN
cord-336510-qzm9wgde	2	23	:	:	:
cord-336510-qzm9wgde	3	1	Virol	Virol	NNP
cord-336510-qzm9wgde	3	2	J	J	NNP
cord-336510-qzm9wgde	3	3	DOI	DOI	NNP
cord-336510-qzm9wgde	3	4	:	:	:
cord-336510-qzm9wgde	3	5	10.1186/1743	10.1186/1743	CD
cord-336510-qzm9wgde	3	6	-	-	HYPH
cord-336510-qzm9wgde	3	7	422x-2	422x-2	CD
cord-336510-qzm9wgde	3	8	-	-	SYM
cord-336510-qzm9wgde	3	9	59	59	CD
cord-336510-qzm9wgde	3	10	sha	sha	NNP
cord-336510-qzm9wgde	3	11	:	:	:
cord-336510-qzm9wgde	3	12	33f0a6576216e3c8ff02dcb1affaa66c9f08e30b	33f0a6576216e3c8ff02dcb1affaa66c9f08e30b	CD
cord-336510-qzm9wgde	4	1	doc_id	doc_id	CD
cord-336510-qzm9wgde	4	2	:	:	:
cord-336510-qzm9wgde	5	1	336510	336510	CD
cord-336510-qzm9wgde	5	2	cord_uid	cord_uid	NNP
cord-336510-qzm9wgde	5	3	:	:	:
cord-336510-qzm9wgde	6	1	qzm9wgde	qzm9wgde	NNP
cord-336510-qzm9wgde	6	2	Herpes	Herpes	NNP
cord-336510-qzm9wgde	6	3	simplex	simplex	NN
cord-336510-qzm9wgde	6	4	virus	virus	NN
cord-336510-qzm9wgde	6	5	(	(	-LRB-
cord-336510-qzm9wgde	6	6	HSV	HSV	NNP
cord-336510-qzm9wgde	6	7	)	)	-RRB-
cord-336510-qzm9wgde	6	8	type	type	NN
cord-336510-qzm9wgde	6	9	1	1	CD
cord-336510-qzm9wgde	6	10	and	and	CC
cord-336510-qzm9wgde	6	11	2	2	CD
cord-336510-qzm9wgde	6	12	are	be	VBP
cord-336510-qzm9wgde	6	13	old	old	JJ
cord-336510-qzm9wgde	6	14	viruses	virus	NNS
cord-336510-qzm9wgde	6	15	,	,	,
cord-336510-qzm9wgde	6	16	with	with	IN
cord-336510-qzm9wgde	6	17	a	a	DT
cord-336510-qzm9wgde	6	18	history	history	NN
cord-336510-qzm9wgde	6	19	of	of	IN
cord-336510-qzm9wgde	6	20	evolution	evolution	NN
cord-336510-qzm9wgde	6	21	shared	share	VBN
cord-336510-qzm9wgde	6	22	with	with	IN
cord-336510-qzm9wgde	6	23	humans	human	NNS
cord-336510-qzm9wgde	6	24	.	.	.
cord-336510-qzm9wgde	7	1	Thus	thus	RB
cord-336510-qzm9wgde	7	2	,	,	,
cord-336510-qzm9wgde	7	3	it	-PRON-	PRP
cord-336510-qzm9wgde	7	4	is	be	VBZ
cord-336510-qzm9wgde	7	5	generally	generally	RB
cord-336510-qzm9wgde	7	6	well	well	RB
cord-336510-qzm9wgde	7	7	-	-	HYPH
cord-336510-qzm9wgde	7	8	adapted	adapt	VBN
cord-336510-qzm9wgde	7	9	viruses	virus	NNS
cord-336510-qzm9wgde	7	10	,	,	,
cord-336510-qzm9wgde	7	11	infecting	infect	VBG
cord-336510-qzm9wgde	7	12	many	many	JJ
cord-336510-qzm9wgde	7	13	of	of	IN
cord-336510-qzm9wgde	7	14	us	-PRON-	PRP
cord-336510-qzm9wgde	7	15	without	without	IN
cord-336510-qzm9wgde	7	16	doing	do	VBG
cord-336510-qzm9wgde	7	17	much	much	JJ
cord-336510-qzm9wgde	7	18	harm	harm	NN
cord-336510-qzm9wgde	7	19	,	,	,
cord-336510-qzm9wgde	7	20	and	and	CC
cord-336510-qzm9wgde	7	21	with	with	IN
cord-336510-qzm9wgde	7	22	the	the	DT
cord-336510-qzm9wgde	7	23	capacity	capacity	NN
cord-336510-qzm9wgde	7	24	to	to	TO
cord-336510-qzm9wgde	7	25	hide	hide	VB
cord-336510-qzm9wgde	7	26	in	in	IN
cord-336510-qzm9wgde	7	27	our	-PRON-	PRP$
cord-336510-qzm9wgde	7	28	neurons	neuron	NNS
cord-336510-qzm9wgde	7	29	for	for	IN
cord-336510-qzm9wgde	7	30	life	life	NN
cord-336510-qzm9wgde	7	31	.	.	.
cord-336510-qzm9wgde	8	1	In	in	IN
cord-336510-qzm9wgde	8	2	rare	rare	JJ
cord-336510-qzm9wgde	8	3	situations	situation	NNS
cord-336510-qzm9wgde	8	4	,	,	,
cord-336510-qzm9wgde	8	5	however	however	RB
cord-336510-qzm9wgde	8	6	,	,	,
cord-336510-qzm9wgde	8	7	the	the	DT
cord-336510-qzm9wgde	8	8	primary	primary	JJ
cord-336510-qzm9wgde	8	9	infection	infection	NN
cord-336510-qzm9wgde	8	10	becomes	become	VBZ
cord-336510-qzm9wgde	8	11	generalized	generalized	JJ
cord-336510-qzm9wgde	8	12	or	or	CC
cord-336510-qzm9wgde	8	13	involves	involve	VBZ
cord-336510-qzm9wgde	8	14	the	the	DT
cord-336510-qzm9wgde	8	15	brain	brain	NN
cord-336510-qzm9wgde	8	16	.	.	.
cord-336510-qzm9wgde	9	1	Normally	normally	RB
cord-336510-qzm9wgde	9	2	,	,	,
cord-336510-qzm9wgde	9	3	the	the	DT
cord-336510-qzm9wgde	9	4	primary	primary	JJ
cord-336510-qzm9wgde	9	5	HSV	HSV	NNP
cord-336510-qzm9wgde	9	6	infection	infection	NN
cord-336510-qzm9wgde	9	7	is	be	VBZ
cord-336510-qzm9wgde	9	8	asymptomatic	asymptomatic	JJ
cord-336510-qzm9wgde	9	9	,	,	,
cord-336510-qzm9wgde	9	10	and	and	CC
cord-336510-qzm9wgde	9	11	a	a	DT
cord-336510-qzm9wgde	9	12	crucial	crucial	JJ
cord-336510-qzm9wgde	9	13	element	element	NN
cord-336510-qzm9wgde	9	14	in	in	IN
cord-336510-qzm9wgde	9	15	the	the	DT
cord-336510-qzm9wgde	9	16	early	early	JJ
cord-336510-qzm9wgde	9	17	restriction	restriction	NN
cord-336510-qzm9wgde	9	18	of	of	IN
cord-336510-qzm9wgde	9	19	virus	virus	NN
cord-336510-qzm9wgde	9	20	replication	replication	NN
cord-336510-qzm9wgde	9	21	and	and	CC
cord-336510-qzm9wgde	9	22	thus	thus	RB
cord-336510-qzm9wgde	9	23	avoidance	avoidance	NN
cord-336510-qzm9wgde	9	24	of	of	IN
cord-336510-qzm9wgde	9	25	symptoms	symptom	NNS
cord-336510-qzm9wgde	9	26	from	from	IN
cord-336510-qzm9wgde	9	27	the	the	DT
cord-336510-qzm9wgde	9	28	infection	infection	NN
cord-336510-qzm9wgde	9	29	is	be	VBZ
cord-336510-qzm9wgde	9	30	the	the	DT
cord-336510-qzm9wgde	9	31	concerted	concerted	JJ
cord-336510-qzm9wgde	9	32	action	action	NN
cord-336510-qzm9wgde	9	33	of	of	IN
cord-336510-qzm9wgde	9	34	different	different	JJ
cord-336510-qzm9wgde	9	35	arms	arm	NNS
cord-336510-qzm9wgde	9	36	of	of	IN
cord-336510-qzm9wgde	9	37	the	the	DT
cord-336510-qzm9wgde	9	38	innate	innate	JJ
cord-336510-qzm9wgde	9	39	immune	immune	JJ
cord-336510-qzm9wgde	9	40	response	response	NN
cord-336510-qzm9wgde	9	41	.	.	.
cord-336510-qzm9wgde	10	1	An	an	DT
cord-336510-qzm9wgde	10	2	early	early	JJ
cord-336510-qzm9wgde	10	3	and	and	CC
cord-336510-qzm9wgde	10	4	light	light	JJ
cord-336510-qzm9wgde	10	5	struggle	struggle	NN
cord-336510-qzm9wgde	10	6	inhibiting	inhibit	VBG
cord-336510-qzm9wgde	10	7	some	some	DT
cord-336510-qzm9wgde	10	8	HSV	HSV	NNP
cord-336510-qzm9wgde	10	9	replication	replication	NN
cord-336510-qzm9wgde	10	10	will	will	MD
cord-336510-qzm9wgde	10	11	spare	spare	VB
cord-336510-qzm9wgde	10	12	the	the	DT
cord-336510-qzm9wgde	10	13	host	host	NN
cord-336510-qzm9wgde	10	14	from	from	IN
cord-336510-qzm9wgde	10	15	the	the	DT
cord-336510-qzm9wgde	10	16	real	real	JJ
cord-336510-qzm9wgde	10	17	war	war	NN
cord-336510-qzm9wgde	10	18	against	against	IN
cord-336510-qzm9wgde	10	19	huge	huge	JJ
cord-336510-qzm9wgde	10	20	amounts	amount	NNS
cord-336510-qzm9wgde	10	21	of	of	IN
cord-336510-qzm9wgde	10	22	virus	virus	NN
cord-336510-qzm9wgde	10	23	later	later	RB
cord-336510-qzm9wgde	10	24	in	in	IN
cord-336510-qzm9wgde	10	25	infection	infection	NN
cord-336510-qzm9wgde	10	26	.	.	.
cord-336510-qzm9wgde	11	1	As	as	RB
cord-336510-qzm9wgde	11	2	far	far	RB
cord-336510-qzm9wgde	11	3	as	as	IN
cord-336510-qzm9wgde	11	4	such	such	PDT
cord-336510-qzm9wgde	11	5	a	a	DT
cord-336510-qzm9wgde	11	6	war	war	NN
cord-336510-qzm9wgde	11	7	will	will	MD
cord-336510-qzm9wgde	11	8	jeopardize	jeopardize	VB
cord-336510-qzm9wgde	11	9	the	the	DT
cord-336510-qzm9wgde	11	10	life	life	NN
cord-336510-qzm9wgde	11	11	of	of	IN
cord-336510-qzm9wgde	11	12	the	the	DT
cord-336510-qzm9wgde	11	13	host	host	NN
cord-336510-qzm9wgde	11	14	,	,	,
cord-336510-qzm9wgde	11	15	it	-PRON-	PRP
cord-336510-qzm9wgde	11	16	will	will	MD
cord-336510-qzm9wgde	11	17	be	be	VB
cord-336510-qzm9wgde	11	18	in	in	IN
cord-336510-qzm9wgde	11	19	both	both	DT
cord-336510-qzm9wgde	11	20	interests	interest	NNS
cord-336510-qzm9wgde	11	21	,	,	,
cord-336510-qzm9wgde	11	22	including	include	VBG
cord-336510-qzm9wgde	11	23	the	the	DT
cord-336510-qzm9wgde	11	24	virus	virus	NN
cord-336510-qzm9wgde	11	25	,	,	,
cord-336510-qzm9wgde	11	26	to	to	TO
cord-336510-qzm9wgde	11	27	settle	settle	VB
cord-336510-qzm9wgde	11	28	the	the	DT
cord-336510-qzm9wgde	11	29	conflict	conflict	NN
cord-336510-qzm9wgde	11	30	amicably	amicably	RB
cord-336510-qzm9wgde	11	31	.	.	.
cord-336510-qzm9wgde	12	1	Some	some	DT
cord-336510-qzm9wgde	12	2	important	important	JJ
cord-336510-qzm9wgde	12	3	weapons	weapon	NNS
cord-336510-qzm9wgde	12	4	of	of	IN
cord-336510-qzm9wgde	12	5	the	the	DT
cord-336510-qzm9wgde	12	6	unspecific	unspecific	JJ
cord-336510-qzm9wgde	12	7	defence	defence	NN
cord-336510-qzm9wgde	12	8	and	and	CC
cord-336510-qzm9wgde	12	9	the	the	DT
cord-336510-qzm9wgde	12	10	early	early	JJ
cord-336510-qzm9wgde	12	11	strikes	strike	NNS
cord-336510-qzm9wgde	12	12	and	and	CC
cord-336510-qzm9wgde	12	13	beginning	begin	VBG
cord-336510-qzm9wgde	12	14	battle	battle	NN
cord-336510-qzm9wgde	12	15	during	during	IN
cord-336510-qzm9wgde	12	16	the	the	DT
cord-336510-qzm9wgde	12	17	first	first	JJ
cord-336510-qzm9wgde	12	18	days	day	NNS
cord-336510-qzm9wgde	12	19	of	of	IN
cord-336510-qzm9wgde	12	20	a	a	DT
cord-336510-qzm9wgde	12	21	HSV	HSV	NNP
cord-336510-qzm9wgde	12	22	infection	infection	NN
cord-336510-qzm9wgde	12	23	are	be	VBP
cord-336510-qzm9wgde	12	24	discussed	discuss	VBN
cord-336510-qzm9wgde	12	25	in	in	IN
cord-336510-qzm9wgde	12	26	this	this	DT
cord-336510-qzm9wgde	12	27	review	review	NN
cord-336510-qzm9wgde	12	28	.	.	.
cord-336510-qzm9wgde	13	1	Generally	generally	RB
cord-336510-qzm9wgde	13	2	,	,	,
cord-336510-qzm9wgde	13	3	macrophages	macrophage	NNS
cord-336510-qzm9wgde	13	4	are	be	VBP
cord-336510-qzm9wgde	13	5	orchestrating	orchestrate	VBG
cord-336510-qzm9wgde	13	6	a	a	DT
cord-336510-qzm9wgde	13	7	multitude	multitude	NN
cord-336510-qzm9wgde	13	8	of	of	IN
cord-336510-qzm9wgde	13	9	anti	anti	JJ
cord-336510-qzm9wgde	13	10	-	-	JJ
cord-336510-qzm9wgde	13	11	herpetic	herpetic	JJ
cord-336510-qzm9wgde	13	12	actions	action	NNS
cord-336510-qzm9wgde	13	13	during	during	IN
cord-336510-qzm9wgde	13	14	the	the	DT
cord-336510-qzm9wgde	13	15	first	first	JJ
cord-336510-qzm9wgde	13	16	hours	hour	NNS
cord-336510-qzm9wgde	13	17	of	of	IN
cord-336510-qzm9wgde	13	18	the	the	DT
cord-336510-qzm9wgde	13	19	attack	attack	NN
cord-336510-qzm9wgde	13	20	.	.	.
cord-336510-qzm9wgde	14	1	In	in	IN
cord-336510-qzm9wgde	14	2	a	a	DT
cord-336510-qzm9wgde	14	3	first	first	JJ
cord-336510-qzm9wgde	14	4	wave	wave	NN
cord-336510-qzm9wgde	14	5	of	of	IN
cord-336510-qzm9wgde	14	6	responses	response	NNS
cord-336510-qzm9wgde	14	7	,	,	,
cord-336510-qzm9wgde	14	8	cytokines	cytokine	NNS
cord-336510-qzm9wgde	14	9	,	,	,
cord-336510-qzm9wgde	14	10	primarily	primarily	RB
cord-336510-qzm9wgde	14	11	type	type	NN
cord-336510-qzm9wgde	14	12	I	-PRON-	PRP
cord-336510-qzm9wgde	14	13	interferons	interferon	NNS
cord-336510-qzm9wgde	14	14	(	(	-LRB-
cord-336510-qzm9wgde	14	15	IFN	IFN	NNP
cord-336510-qzm9wgde	14	16	)	)	-RRB-
cord-336510-qzm9wgde	14	17	and	and	CC
cord-336510-qzm9wgde	14	18	tumour	tumour	NN
cord-336510-qzm9wgde	14	19	necrosis	necrosis	NN
cord-336510-qzm9wgde	14	20	factor	factor	NN
cord-336510-qzm9wgde	14	21	are	be	VBP
cord-336510-qzm9wgde	14	22	produced	produce	VBN
cord-336510-qzm9wgde	14	23	and	and	CC
cord-336510-qzm9wgde	14	24	exert	exert	VB
cord-336510-qzm9wgde	14	25	a	a	DT
cord-336510-qzm9wgde	14	26	direct	direct	JJ
cord-336510-qzm9wgde	14	27	antiviral	antiviral	JJ
cord-336510-qzm9wgde	14	28	effect	effect	NN
cord-336510-qzm9wgde	14	29	and	and	CC
cord-336510-qzm9wgde	14	30	activate	activate	VB
cord-336510-qzm9wgde	14	31	the	the	DT
cord-336510-qzm9wgde	14	32	macrophages	macrophage	NNS
cord-336510-qzm9wgde	14	33	themselves	-PRON-	PRP
cord-336510-qzm9wgde	14	34	.	.	.
cord-336510-qzm9wgde	15	1	In	in	IN
cord-336510-qzm9wgde	15	2	the	the	DT
cord-336510-qzm9wgde	15	3	next	next	JJ
cord-336510-qzm9wgde	15	4	wave	wave	NN
cord-336510-qzm9wgde	15	5	,	,	,
cord-336510-qzm9wgde	15	6	interleukin	interleukin	FW
cord-336510-qzm9wgde	15	7	(	(	-LRB-
cord-336510-qzm9wgde	15	8	IL)-12	il)-12	NN
cord-336510-qzm9wgde	15	9	together	together	RB
cord-336510-qzm9wgde	15	10	with	with	IN
cord-336510-qzm9wgde	15	11	the	the	DT
cord-336510-qzm9wgde	15	12	above	above	JJ
cord-336510-qzm9wgde	15	13	and	and	CC
cord-336510-qzm9wgde	15	14	other	other	JJ
cord-336510-qzm9wgde	15	15	cytokines	cytokine	NNS
cord-336510-qzm9wgde	15	16	induce	induce	VBP
cord-336510-qzm9wgde	15	17	production	production	NN
cord-336510-qzm9wgde	15	18	of	of	IN
cord-336510-qzm9wgde	15	19	IFN	IFN	NNP
cord-336510-qzm9wgde	15	20	-	-	HYPH
cord-336510-qzm9wgde	15	21	γ	γ	NNP
cord-336510-qzm9wgde	15	22	in	in	IN
cord-336510-qzm9wgde	15	23	mainly	mainly	RB
cord-336510-qzm9wgde	15	24	NK	NK	NNP
cord-336510-qzm9wgde	15	25	cells	cell	NNS
cord-336510-qzm9wgde	15	26	.	.	.
cord-336510-qzm9wgde	16	1	Many	many	JJ
cord-336510-qzm9wgde	16	2	positive	positive	JJ
cord-336510-qzm9wgde	16	3	feed	feed	NN
cord-336510-qzm9wgde	16	4	-	-	HYPH
cord-336510-qzm9wgde	16	5	back	back	NN
cord-336510-qzm9wgde	16	6	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	16	7	and	and	CC
cord-336510-qzm9wgde	16	8	synergistic	synergistic	JJ
cord-336510-qzm9wgde	16	9	interactions	interaction	NNS
cord-336510-qzm9wgde	16	10	intensify	intensify	VBP
cord-336510-qzm9wgde	16	11	these	these	DT
cord-336510-qzm9wgde	16	12	systems	system	NNS
cord-336510-qzm9wgde	16	13	and	and	CC
cord-336510-qzm9wgde	16	14	give	give	VB
cord-336510-qzm9wgde	16	15	rise	rise	NN
cord-336510-qzm9wgde	16	16	to	to	IN
cord-336510-qzm9wgde	16	17	heavy	heavy	JJ
cord-336510-qzm9wgde	16	18	antiviral	antiviral	JJ
cord-336510-qzm9wgde	16	19	weapons	weapon	NNS
cord-336510-qzm9wgde	16	20	such	such	JJ
cord-336510-qzm9wgde	16	21	as	as	IN
cord-336510-qzm9wgde	16	22	reactive	reactive	JJ
cord-336510-qzm9wgde	16	23	oxygen	oxygen	NN
cord-336510-qzm9wgde	16	24	species	specie	NNS
cord-336510-qzm9wgde	16	25	and	and	CC
cord-336510-qzm9wgde	16	26	nitric	nitric	NN
cord-336510-qzm9wgde	16	27	oxide	oxide	NN
cord-336510-qzm9wgde	16	28	.	.	.
cord-336510-qzm9wgde	17	1	This	this	DT
cord-336510-qzm9wgde	17	2	results	result	VBZ
cord-336510-qzm9wgde	17	3	in	in	IN
cord-336510-qzm9wgde	17	4	the	the	DT
cord-336510-qzm9wgde	17	5	generation	generation	NN
cord-336510-qzm9wgde	17	6	of	of	IN
cord-336510-qzm9wgde	17	7	an	an	DT
cord-336510-qzm9wgde	17	8	alliance	alliance	NN
cord-336510-qzm9wgde	17	9	against	against	IN
cord-336510-qzm9wgde	17	10	the	the	DT
cord-336510-qzm9wgde	17	11	viral	viral	JJ
cord-336510-qzm9wgde	17	12	enemy	enemy	NN
cord-336510-qzm9wgde	17	13	.	.	.
cord-336510-qzm9wgde	18	1	However	however	RB
cord-336510-qzm9wgde	18	2	,	,	,
cord-336510-qzm9wgde	18	3	these	these	DT
cord-336510-qzm9wgde	18	4	heavy	heavy	JJ
cord-336510-qzm9wgde	18	5	weapons	weapon	NNS
cord-336510-qzm9wgde	18	6	have	have	VBP
cord-336510-qzm9wgde	18	7	to	to	TO
cord-336510-qzm9wgde	18	8	be	be	VB
cord-336510-qzm9wgde	18	9	controlled	control	VBN
cord-336510-qzm9wgde	18	10	to	to	TO
cord-336510-qzm9wgde	18	11	avoid	avoid	VB
cord-336510-qzm9wgde	18	12	too	too	RB
cord-336510-qzm9wgde	18	13	much	much	JJ
cord-336510-qzm9wgde	18	14	harm	harm	NN
cord-336510-qzm9wgde	18	15	to	to	IN
cord-336510-qzm9wgde	18	16	the	the	DT
cord-336510-qzm9wgde	18	17	host	host	NN
cord-336510-qzm9wgde	18	18	.	.	.
cord-336510-qzm9wgde	19	1	By	by	IN
cord-336510-qzm9wgde	19	2	IL-4	IL-4	NNP
cord-336510-qzm9wgde	19	3	and	and	CC
cord-336510-qzm9wgde	19	4	others	other	NNS
cord-336510-qzm9wgde	19	5	,	,	,
cord-336510-qzm9wgde	19	6	these	these	DT
cord-336510-qzm9wgde	19	7	reactions	reaction	NNS
cord-336510-qzm9wgde	19	8	are	be	VBP
cord-336510-qzm9wgde	19	9	hampered	hamper	VBN
cord-336510-qzm9wgde	19	10	,	,	,
cord-336510-qzm9wgde	19	11	but	but	CC
cord-336510-qzm9wgde	19	12	they	-PRON-	PRP
cord-336510-qzm9wgde	19	13	are	be	VBP
cord-336510-qzm9wgde	19	14	still	still	RB
cord-336510-qzm9wgde	19	15	allowed	allow	VBN
cord-336510-qzm9wgde	19	16	in	in	IN
cord-336510-qzm9wgde	19	17	foci	foci	NN
cord-336510-qzm9wgde	19	18	of	of	IN
cord-336510-qzm9wgde	19	19	HSV	HSV	NNP
cord-336510-qzm9wgde	19	20	replication	replication	NN
cord-336510-qzm9wgde	19	21	,	,	,
cord-336510-qzm9wgde	19	22	thus	thus	RB
cord-336510-qzm9wgde	19	23	focusing	focus	VBG
cord-336510-qzm9wgde	19	24	the	the	DT
cord-336510-qzm9wgde	19	25	activity	activity	NN
cord-336510-qzm9wgde	19	26	to	to	IN
cord-336510-qzm9wgde	19	27	only	only	RB
cord-336510-qzm9wgde	19	28	relevant	relevant	JJ
cord-336510-qzm9wgde	19	29	sites	site	NNS
cord-336510-qzm9wgde	19	30	.	.	.
cord-336510-qzm9wgde	20	1	So	so	RB
cord-336510-qzm9wgde	20	2	,	,	,
cord-336510-qzm9wgde	20	3	no	no	DT
cord-336510-qzm9wgde	20	4	hero	hero	NN
cord-336510-qzm9wgde	20	5	does	do	VBZ
cord-336510-qzm9wgde	20	6	it	-PRON-	PRP
cord-336510-qzm9wgde	20	7	alone	alone	JJ
cord-336510-qzm9wgde	20	8	.	.	.
cord-336510-qzm9wgde	21	1	Rather	rather	RB
cord-336510-qzm9wgde	21	2	,	,	,
cord-336510-qzm9wgde	21	3	an	an	DT
cord-336510-qzm9wgde	21	4	alliance	alliance	NN
cord-336510-qzm9wgde	21	5	of	of	IN
cord-336510-qzm9wgde	21	6	cytokines	cytokine	NNS
cord-336510-qzm9wgde	21	7	,	,	,
cord-336510-qzm9wgde	21	8	macrophages	macrophage	NNS
cord-336510-qzm9wgde	21	9	and	and	CC
cord-336510-qzm9wgde	21	10	other	other	JJ
cord-336510-qzm9wgde	21	11	cells	cell	NNS
cord-336510-qzm9wgde	21	12	seems	seem	VBZ
cord-336510-qzm9wgde	21	13	to	to	TO
cord-336510-qzm9wgde	21	14	play	play	VB
cord-336510-qzm9wgde	21	15	a	a	DT
cord-336510-qzm9wgde	21	16	central	central	JJ
cord-336510-qzm9wgde	21	17	role	role	NN
cord-336510-qzm9wgde	21	18	.	.	.
cord-336510-qzm9wgde	22	1	Implications	implication	NNS
cord-336510-qzm9wgde	22	2	of	of	IN
cord-336510-qzm9wgde	22	3	this	this	DT
cord-336510-qzm9wgde	22	4	for	for	IN
cord-336510-qzm9wgde	22	5	future	future	JJ
cord-336510-qzm9wgde	22	6	treatment	treatment	NN
cord-336510-qzm9wgde	22	7	modalities	modality	NNS
cord-336510-qzm9wgde	22	8	are	be	VBP
cord-336510-qzm9wgde	22	9	shortly	shortly	RB
cord-336510-qzm9wgde	22	10	considered	consider	VBN
cord-336510-qzm9wgde	22	11	.	.	.
cord-336510-qzm9wgde	23	1	Virus	virus	NN
cord-336510-qzm9wgde	23	2	-	-	HYPH
cord-336510-qzm9wgde	23	3	host	host	NN
cord-336510-qzm9wgde	23	4	interactions	interaction	NNS
cord-336510-qzm9wgde	23	5	are	be	VBP
cord-336510-qzm9wgde	23	6	crucial	crucial	JJ
cord-336510-qzm9wgde	23	7	for	for	IN
cord-336510-qzm9wgde	23	8	the	the	DT
cord-336510-qzm9wgde	23	9	outcome	outcome	NN
cord-336510-qzm9wgde	23	10	of	of	IN
cord-336510-qzm9wgde	23	11	infections	infection	NNS
cord-336510-qzm9wgde	23	12	.	.	.
cord-336510-qzm9wgde	24	1	Several	several	JJ
cord-336510-qzm9wgde	24	2	strategies	strategy	NNS
cord-336510-qzm9wgde	24	3	have	have	VBP
cord-336510-qzm9wgde	24	4	been	be	VBN
cord-336510-qzm9wgde	24	5	utilized	utilize	VBN
cord-336510-qzm9wgde	24	6	by	by	IN
cord-336510-qzm9wgde	24	7	viruses	virus	NNS
cord-336510-qzm9wgde	24	8	to	to	TO
cord-336510-qzm9wgde	24	9	overcome	overcome	VB
cord-336510-qzm9wgde	24	10	the	the	DT
cord-336510-qzm9wgde	24	11	host	host	NN
cord-336510-qzm9wgde	24	12	defence	defence	NN
cord-336510-qzm9wgde	24	13	.	.	.
cord-336510-qzm9wgde	25	1	For	for	IN
cord-336510-qzm9wgde	25	2	the	the	DT
cord-336510-qzm9wgde	25	3	virus	virus	NN
cord-336510-qzm9wgde	25	4	to	to	TO
cord-336510-qzm9wgde	25	5	be	be	VB
cord-336510-qzm9wgde	25	6	successful	successful	JJ
cord-336510-qzm9wgde	25	7	,	,	,
cord-336510-qzm9wgde	25	8	these	these	DT
cord-336510-qzm9wgde	25	9	evasive	evasive	JJ
cord-336510-qzm9wgde	25	10	strategies	strategy	NNS
cord-336510-qzm9wgde	25	11	have	have	VBP
cord-336510-qzm9wgde	25	12	to	to	TO
cord-336510-qzm9wgde	25	13	be	be	VB
cord-336510-qzm9wgde	25	14	balanced	balance	VBN
cord-336510-qzm9wgde	25	15	with	with	IN
cord-336510-qzm9wgde	25	16	the	the	DT
cord-336510-qzm9wgde	25	17	pathology	pathology	NN
cord-336510-qzm9wgde	25	18	induced	induce	VBN
cord-336510-qzm9wgde	25	19	and	and	CC
cord-336510-qzm9wgde	25	20	the	the	DT
cord-336510-qzm9wgde	25	21	possibilities	possibility	NNS
cord-336510-qzm9wgde	25	22	of	of	IN
cord-336510-qzm9wgde	25	23	transmission	transmission	NN
cord-336510-qzm9wgde	25	24	to	to	IN
cord-336510-qzm9wgde	25	25	new	new	JJ
cord-336510-qzm9wgde	25	26	susceptible	susceptible	JJ
cord-336510-qzm9wgde	25	27	individuals	individual	NNS
cord-336510-qzm9wgde	25	28	.	.	.
cord-336510-qzm9wgde	26	1	The	the	DT
cord-336510-qzm9wgde	26	2	mammalian	mammalian	JJ
cord-336510-qzm9wgde	26	3	host	host	NN
cord-336510-qzm9wgde	26	4	utilizes	utilize	VBZ
cord-336510-qzm9wgde	26	5	ubiquitous	ubiquitous	JJ
cord-336510-qzm9wgde	26	6	and	and	CC
cord-336510-qzm9wgde	26	7	redundant	redundant	JJ
cord-336510-qzm9wgde	26	8	antiviral	antiviral	JJ
cord-336510-qzm9wgde	26	9	defence	defence	NN
cord-336510-qzm9wgde	26	10	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	26	11	.	.	.
cord-336510-qzm9wgde	27	1	In	in	IN
cord-336510-qzm9wgde	27	2	different	different	JJ
cord-336510-qzm9wgde	27	3	viral	viral	JJ
cord-336510-qzm9wgde	27	4	infections	infection	NNS
cord-336510-qzm9wgde	27	5	,	,	,
cord-336510-qzm9wgde	27	6	different	different	JJ
cord-336510-qzm9wgde	27	7	parts	part	NNS
cord-336510-qzm9wgde	27	8	of	of	IN
cord-336510-qzm9wgde	27	9	the	the	DT
cord-336510-qzm9wgde	27	10	host	host	NN
cord-336510-qzm9wgde	27	11	defence	defence	NN
cord-336510-qzm9wgde	27	12	seem	seem	VBP
cord-336510-qzm9wgde	27	13	to	to	TO
cord-336510-qzm9wgde	27	14	be	be	VB
cord-336510-qzm9wgde	27	15	crucial	crucial	JJ
cord-336510-qzm9wgde	27	16	.	.	.
cord-336510-qzm9wgde	28	1	However	however	RB
cord-336510-qzm9wgde	28	2	,	,	,
cord-336510-qzm9wgde	28	3	the	the	DT
cord-336510-qzm9wgde	28	4	redundancy	redundancy	NN
cord-336510-qzm9wgde	28	5	ensures	ensure	VBZ
cord-336510-qzm9wgde	28	6	that	that	IN
cord-336510-qzm9wgde	28	7	other	other	JJ
cord-336510-qzm9wgde	28	8	systems	system	NNS
cord-336510-qzm9wgde	28	9	are	be	VBP
cord-336510-qzm9wgde	28	10	ready	ready	JJ
cord-336510-qzm9wgde	28	11	to	to	TO
cord-336510-qzm9wgde	28	12	take	take	VB
cord-336510-qzm9wgde	28	13	over	over	RP
cord-336510-qzm9wgde	28	14	,	,	,
cord-336510-qzm9wgde	28	15	if	if	IN
cord-336510-qzm9wgde	28	16	one	one	CD
cord-336510-qzm9wgde	28	17	of	of	IN
cord-336510-qzm9wgde	28	18	them	-PRON-	PRP
cord-336510-qzm9wgde	28	19	fails	fail	VBZ
cord-336510-qzm9wgde	28	20	.	.	.
cord-336510-qzm9wgde	29	1	The	the	DT
cord-336510-qzm9wgde	29	2	final	final	JJ
cord-336510-qzm9wgde	29	3	outcome	outcome	NN
cord-336510-qzm9wgde	29	4	of	of	IN
cord-336510-qzm9wgde	29	5	a	a	DT
cord-336510-qzm9wgde	29	6	viral	viral	JJ
cord-336510-qzm9wgde	29	7	infection	infection	NN
cord-336510-qzm9wgde	29	8	depends	depend	VBZ
cord-336510-qzm9wgde	29	9	on	on	IN
cord-336510-qzm9wgde	29	10	a	a	DT
cord-336510-qzm9wgde	29	11	delicate	delicate	JJ
cord-336510-qzm9wgde	29	12	regulation	regulation	NN
cord-336510-qzm9wgde	29	13	and	and	CC
cord-336510-qzm9wgde	29	14	timing	timing	NN
cord-336510-qzm9wgde	29	15	of	of	IN
cord-336510-qzm9wgde	29	16	these	these	DT
cord-336510-qzm9wgde	29	17	antiviral	antiviral	JJ
cord-336510-qzm9wgde	29	18	effector	effector	NN
cord-336510-qzm9wgde	29	19	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	29	20	in	in	IN
cord-336510-qzm9wgde	29	21	response	response	NN
cord-336510-qzm9wgde	29	22	to	to	IN
cord-336510-qzm9wgde	29	23	the	the	DT
cord-336510-qzm9wgde	29	24	invading	invade	VBG
cord-336510-qzm9wgde	29	25	virus	virus	NN
cord-336510-qzm9wgde	29	26	.	.	.
cord-336510-qzm9wgde	30	1	A	a	DT
cord-336510-qzm9wgde	30	2	viral	viral	JJ
cord-336510-qzm9wgde	30	3	infection	infection	NN
cord-336510-qzm9wgde	30	4	of	of	IN
cord-336510-qzm9wgde	30	5	an	an	DT
cord-336510-qzm9wgde	30	6	individual	individual	NN
cord-336510-qzm9wgde	30	7	thus	thus	RB
cord-336510-qzm9wgde	30	8	involves	involve	VBZ
cord-336510-qzm9wgde	30	9	a	a	DT
cord-336510-qzm9wgde	30	10	conflict	conflict	NN
cord-336510-qzm9wgde	30	11	between	between	IN
cord-336510-qzm9wgde	30	12	the	the	DT
cord-336510-qzm9wgde	30	13	virus	virus	NN
cord-336510-qzm9wgde	30	14	and	and	CC
cord-336510-qzm9wgde	30	15	the	the	DT
cord-336510-qzm9wgde	30	16	host	host	NN
cord-336510-qzm9wgde	30	17	,	,	,
cord-336510-qzm9wgde	30	18	which	which	WDT
cord-336510-qzm9wgde	30	19	could	could	MD
cord-336510-qzm9wgde	30	20	conceptually	conceptually	RB
cord-336510-qzm9wgde	30	21	be	be	VB
cord-336510-qzm9wgde	30	22	viewed	view	VBN
cord-336510-qzm9wgde	30	23	upon	upon	IN
cord-336510-qzm9wgde	30	24	as	as	IN
cord-336510-qzm9wgde	30	25	a	a	DT
cord-336510-qzm9wgde	30	26	human	human	JJ
cord-336510-qzm9wgde	30	27	controversy	controversy	NN
cord-336510-qzm9wgde	30	28	escalating	escalate	VBG
cord-336510-qzm9wgde	30	29	to	to	IN
cord-336510-qzm9wgde	30	30	invasion	invasion	NN
cord-336510-qzm9wgde	30	31	and	and	CC
cord-336510-qzm9wgde	30	32	armed	armed	JJ
cord-336510-qzm9wgde	30	33	struggle	struggle	NN
cord-336510-qzm9wgde	30	34	.	.	.
cord-336510-qzm9wgde	31	1	To	to	TO
cord-336510-qzm9wgde	31	2	understand	understand	VB
cord-336510-qzm9wgde	31	3	the	the	DT
cord-336510-qzm9wgde	31	4	resulting	result	VBG
cord-336510-qzm9wgde	31	5	course	course	NN
cord-336510-qzm9wgde	31	6	of	of	IN
cord-336510-qzm9wgde	31	7	events	event	NNS
cord-336510-qzm9wgde	31	8	it	-PRON-	PRP
cord-336510-qzm9wgde	31	9	is	be	VBZ
cord-336510-qzm9wgde	31	10	important	important	JJ
cord-336510-qzm9wgde	31	11	to	to	TO
cord-336510-qzm9wgde	31	12	know	know	VB
cord-336510-qzm9wgde	31	13	each	each	DT
cord-336510-qzm9wgde	31	14	party	party	NN
cord-336510-qzm9wgde	31	15	of	of	IN
cord-336510-qzm9wgde	31	16	the	the	DT
cord-336510-qzm9wgde	31	17	conflict	conflict	NN
cord-336510-qzm9wgde	31	18	and	and	CC
cord-336510-qzm9wgde	31	19	to	to	TO
cord-336510-qzm9wgde	31	20	conduct	conduct	VB
cord-336510-qzm9wgde	31	21	an	an	DT
cord-336510-qzm9wgde	31	22	analysis	analysis	NN
cord-336510-qzm9wgde	31	23	of	of	IN
cord-336510-qzm9wgde	31	24	the	the	DT
cord-336510-qzm9wgde	31	25	powerful	powerful	JJ
cord-336510-qzm9wgde	31	26	weapons	weapon	NNS
cord-336510-qzm9wgde	31	27	held	hold	VBN
cord-336510-qzm9wgde	31	28	by	by	IN
cord-336510-qzm9wgde	31	29	each	each	DT
cord-336510-qzm9wgde	31	30	of	of	IN
cord-336510-qzm9wgde	31	31	the	the	DT
cord-336510-qzm9wgde	31	32	combatants	combatant	NNS
cord-336510-qzm9wgde	31	33	.	.	.
cord-336510-qzm9wgde	32	1	The	the	DT
cord-336510-qzm9wgde	32	2	present	present	JJ
cord-336510-qzm9wgde	32	3	review	review	NN
cord-336510-qzm9wgde	32	4	analyzes	analyze	VBZ
cord-336510-qzm9wgde	32	5	the	the	DT
cord-336510-qzm9wgde	32	6	early	early	JJ
cord-336510-qzm9wgde	32	7	non	non	JJ
cord-336510-qzm9wgde	32	8	-	-	JJ
cord-336510-qzm9wgde	32	9	specific	specific	JJ
cord-336510-qzm9wgde	32	10	events	event	NNS
cord-336510-qzm9wgde	32	11	in	in	IN
cord-336510-qzm9wgde	32	12	the	the	DT
cord-336510-qzm9wgde	32	13	conflict	conflict	NN
cord-336510-qzm9wgde	32	14	upon	upon	IN
cord-336510-qzm9wgde	32	15	herpes	herpes	NNP
cord-336510-qzm9wgde	32	16	simplex	simplex	NNP
cord-336510-qzm9wgde	32	17	virus	virus	NN
cord-336510-qzm9wgde	32	18	(	(	-LRB-
cord-336510-qzm9wgde	32	19	HSV	HSV	NNP
cord-336510-qzm9wgde	32	20	)	)	-RRB-
cord-336510-qzm9wgde	32	21	infection	infection	NN
cord-336510-qzm9wgde	32	22	.	.	.
cord-336510-qzm9wgde	33	1	Initially	initially	RB
cord-336510-qzm9wgde	33	2	,	,	,
cord-336510-qzm9wgde	33	3	each	each	DT
cord-336510-qzm9wgde	33	4	participant	participant	NN
cord-336510-qzm9wgde	33	5	of	of	IN
cord-336510-qzm9wgde	33	6	the	the	DT
cord-336510-qzm9wgde	33	7	conflict	conflict	NN
cord-336510-qzm9wgde	33	8	,	,	,
cord-336510-qzm9wgde	33	9	the	the	DT
cord-336510-qzm9wgde	33	10	infecting	infect	VBG
cord-336510-qzm9wgde	33	11	HSV	HSV	NNP
cord-336510-qzm9wgde	33	12	and	and	CC
cord-336510-qzm9wgde	33	13	the	the	DT
cord-336510-qzm9wgde	33	14	non	non	JJ
cord-336510-qzm9wgde	33	15	-	-	JJ
cord-336510-qzm9wgde	33	16	specific	specific	JJ
cord-336510-qzm9wgde	33	17	antiviral	antiviral	JJ
cord-336510-qzm9wgde	33	18	weapons	weapon	NNS
cord-336510-qzm9wgde	33	19	of	of	IN
cord-336510-qzm9wgde	33	20	the	the	DT
cord-336510-qzm9wgde	33	21	host	host	NN
cord-336510-qzm9wgde	33	22	,	,	,
cord-336510-qzm9wgde	33	23	are	be	VBP
cord-336510-qzm9wgde	33	24	described	describe	VBN
cord-336510-qzm9wgde	33	25	.	.	.
cord-336510-qzm9wgde	34	1	Subsequently	subsequently	RB
cord-336510-qzm9wgde	34	2	,	,	,
cord-336510-qzm9wgde	34	3	the	the	DT
cord-336510-qzm9wgde	34	4	early	early	JJ
cord-336510-qzm9wgde	34	5	events	event	NNS
cord-336510-qzm9wgde	34	6	of	of	IN
cord-336510-qzm9wgde	34	7	the	the	DT
cord-336510-qzm9wgde	34	8	conflict	conflict	NN
cord-336510-qzm9wgde	34	9	,	,	,
cord-336510-qzm9wgde	34	10	the	the	DT
cord-336510-qzm9wgde	34	11	armament	armament	NN
cord-336510-qzm9wgde	34	12	,	,	,
cord-336510-qzm9wgde	34	13	early	early	JJ
cord-336510-qzm9wgde	34	14	strikes	strike	NNS
cord-336510-qzm9wgde	34	15	and	and	CC
cord-336510-qzm9wgde	34	16	the	the	DT
cord-336510-qzm9wgde	34	17	opening	opening	NN
cord-336510-qzm9wgde	34	18	battle	battle	NN
cord-336510-qzm9wgde	34	19	between	between	IN
cord-336510-qzm9wgde	34	20	HSV	HSV	NNP
cord-336510-qzm9wgde	34	21	and	and	CC
cord-336510-qzm9wgde	34	22	the	the	DT
cord-336510-qzm9wgde	34	23	host	host	NN
cord-336510-qzm9wgde	34	24	are	be	VBP
cord-336510-qzm9wgde	34	25	discussed	discuss	VBN
cord-336510-qzm9wgde	34	26	.	.	.
cord-336510-qzm9wgde	35	1	Insight	insight	NN
cord-336510-qzm9wgde	35	2	into	into	IN
cord-336510-qzm9wgde	35	3	the	the	DT
cord-336510-qzm9wgde	35	4	early	early	JJ
cord-336510-qzm9wgde	35	5	non	non	JJ
cord-336510-qzm9wgde	35	6	-	-	JJ
cord-336510-qzm9wgde	35	7	specific	specific	JJ
cord-336510-qzm9wgde	35	8	defence	defence	NN
cord-336510-qzm9wgde	35	9	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	35	10	are	be	VBP
cord-336510-qzm9wgde	35	11	important	important	JJ
cord-336510-qzm9wgde	35	12	for	for	IN
cord-336510-qzm9wgde	35	13	our	-PRON-	PRP$
cord-336510-qzm9wgde	35	14	understanding	understanding	NN
cord-336510-qzm9wgde	35	15	of	of	IN
cord-336510-qzm9wgde	35	16	the	the	DT
cord-336510-qzm9wgde	35	17	conflict	conflict	NN
cord-336510-qzm9wgde	35	18	and	and	CC
cord-336510-qzm9wgde	35	19	may	may	MD
cord-336510-qzm9wgde	35	20	indicate	indicate	VB
cord-336510-qzm9wgde	35	21	how	how	WRB
cord-336510-qzm9wgde	35	22	to	to	TO
cord-336510-qzm9wgde	35	23	intervene	intervene	VB
cord-336510-qzm9wgde	35	24	during	during	IN
cord-336510-qzm9wgde	35	25	serious	serious	JJ
cord-336510-qzm9wgde	35	26	systemic	systemic	JJ
cord-336510-qzm9wgde	35	27	infections	infection	NNS
cord-336510-qzm9wgde	35	28	.	.	.
cord-336510-qzm9wgde	36	1	Herpesviruses	Herpesviruses	NNP
cord-336510-qzm9wgde	36	2	are	be	VBP
cord-336510-qzm9wgde	36	3	ubiquitous	ubiquitous	JJ
cord-336510-qzm9wgde	36	4	viruses	virus	NNS
cord-336510-qzm9wgde	36	5	generally	generally	RB
cord-336510-qzm9wgde	36	6	infecting	infect	VBG
cord-336510-qzm9wgde	36	7	humans	human	NNS
cord-336510-qzm9wgde	36	8	early	early	RB
cord-336510-qzm9wgde	36	9	in	in	IN
cord-336510-qzm9wgde	36	10	life	life	NN
cord-336510-qzm9wgde	36	11	.	.	.
cord-336510-qzm9wgde	37	1	The	the	DT
cord-336510-qzm9wgde	37	2	majority	majority	NN
cord-336510-qzm9wgde	37	3	of	of	IN
cord-336510-qzm9wgde	37	4	humans	human	NNS
cord-336510-qzm9wgde	37	5	has	have	VBZ
cord-336510-qzm9wgde	37	6	had	have	VBN
cord-336510-qzm9wgde	37	7	a	a	DT
cord-336510-qzm9wgde	37	8	primary	primary	JJ
cord-336510-qzm9wgde	37	9	infection	infection	NN
cord-336510-qzm9wgde	37	10	with	with	IN
cord-336510-qzm9wgde	37	11	one	one	CD
cord-336510-qzm9wgde	37	12	or	or	CC
cord-336510-qzm9wgde	37	13	more	more	JJR
cord-336510-qzm9wgde	37	14	herpesviruses	herpesviruse	NNS
cord-336510-qzm9wgde	37	15	and	and	CC
cord-336510-qzm9wgde	37	16	harbour	harbour	VB
cord-336510-qzm9wgde	37	17	these	these	DT
cord-336510-qzm9wgde	37	18	viruses	virus	NNS
cord-336510-qzm9wgde	37	19	in	in	IN
cord-336510-qzm9wgde	37	20	a	a	DT
cord-336510-qzm9wgde	37	21	latent	latent	JJ
cord-336510-qzm9wgde	37	22	state	state	NN
cord-336510-qzm9wgde	37	23	for	for	IN
cord-336510-qzm9wgde	37	24	the	the	DT
cord-336510-qzm9wgde	37	25	rest	rest	NN
cord-336510-qzm9wgde	37	26	of	of	IN
cord-336510-qzm9wgde	37	27	their	-PRON-	PRP$
cord-336510-qzm9wgde	37	28	lives	life	NNS
cord-336510-qzm9wgde	37	29	.	.	.
cord-336510-qzm9wgde	38	1	The	the	DT
cord-336510-qzm9wgde	38	2	initial	initial	JJ
cord-336510-qzm9wgde	38	3	infection	infection	NN
cord-336510-qzm9wgde	38	4	is	be	VBZ
cord-336510-qzm9wgde	38	5	most	most	RBS
cord-336510-qzm9wgde	38	6	often	often	RB
cord-336510-qzm9wgde	38	7	asymptomatic	asymptomatic	JJ
cord-336510-qzm9wgde	38	8	,	,	,
cord-336510-qzm9wgde	38	9	but	but	CC
cord-336510-qzm9wgde	38	10	can	can	MD
cord-336510-qzm9wgde	38	11	be	be	VB
cord-336510-qzm9wgde	38	12	symptomatic	symptomatic	JJ
cord-336510-qzm9wgde	38	13	depending	depend	VBG
cord-336510-qzm9wgde	38	14	on	on	IN
cord-336510-qzm9wgde	38	15	the	the	DT
cord-336510-qzm9wgde	38	16	herpesvirus	herpesvirus	NN
cord-336510-qzm9wgde	38	17	in	in	IN
cord-336510-qzm9wgde	38	18	question	question	NN
cord-336510-qzm9wgde	38	19	and	and	CC
cord-336510-qzm9wgde	38	20	the	the	DT
cord-336510-qzm9wgde	38	21	age	age	NN
cord-336510-qzm9wgde	38	22	and	and	CC
cord-336510-qzm9wgde	38	23	immune	immune	JJ
cord-336510-qzm9wgde	38	24	status	status	NN
cord-336510-qzm9wgde	38	25	of	of	IN
cord-336510-qzm9wgde	38	26	the	the	DT
cord-336510-qzm9wgde	38	27	host	host	NN
cord-336510-qzm9wgde	38	28	.	.	.
cord-336510-qzm9wgde	39	1	The	the	DT
cord-336510-qzm9wgde	39	2	viruses	virus	NNS
cord-336510-qzm9wgde	39	3	are	be	VBP
cord-336510-qzm9wgde	39	4	phylogenetically	phylogenetically	RB
cord-336510-qzm9wgde	39	5	old	old	JJ
cord-336510-qzm9wgde	39	6	and	and	CC
cord-336510-qzm9wgde	39	7	humans	human	NNS
cord-336510-qzm9wgde	39	8	and	and	CC
cord-336510-qzm9wgde	39	9	herpesviruses	herpesviruse	NNS
cord-336510-qzm9wgde	39	10	have	have	VBP
cord-336510-qzm9wgde	39	11	evolved	evolve	VBN
cord-336510-qzm9wgde	39	12	together	together	RB
cord-336510-qzm9wgde	39	13	[	[	-LRB-
cord-336510-qzm9wgde	39	14	1	1	CD
cord-336510-qzm9wgde	39	15	]	]	-RRB-
cord-336510-qzm9wgde	39	16	.	.	.
cord-336510-qzm9wgde	40	1	This	this	DT
cord-336510-qzm9wgde	40	2	co	co	NN
cord-336510-qzm9wgde	40	3	-	-	NN
cord-336510-qzm9wgde	40	4	evolution	evolution	NN
cord-336510-qzm9wgde	40	5	has	have	VBZ
cord-336510-qzm9wgde	40	6	created	create	VBN
cord-336510-qzm9wgde	40	7	viruses	virus	NNS
cord-336510-qzm9wgde	40	8	which	which	WDT
cord-336510-qzm9wgde	40	9	are	be	VBP
cord-336510-qzm9wgde	40	10	well	well	RB
cord-336510-qzm9wgde	40	11	adapted	adapt	VBN
cord-336510-qzm9wgde	40	12	to	to	IN
cord-336510-qzm9wgde	40	13	the	the	DT
cord-336510-qzm9wgde	40	14	human	human	JJ
cord-336510-qzm9wgde	40	15	host	host	NN
cord-336510-qzm9wgde	40	16	and	and	CC
cord-336510-qzm9wgde	40	17	environment	environment	NN
cord-336510-qzm9wgde	40	18	.	.	.
cord-336510-qzm9wgde	41	1	Thus	thus	RB
cord-336510-qzm9wgde	41	2	,	,	,
cord-336510-qzm9wgde	41	3	herpesviruses	herpesviruse	NNS
cord-336510-qzm9wgde	41	4	are	be	VBP
cord-336510-qzm9wgde	41	5	capable	capable	JJ
cord-336510-qzm9wgde	41	6	of	of	IN
cord-336510-qzm9wgde	41	7	coping	cope	VBG
cord-336510-qzm9wgde	41	8	with	with	IN
cord-336510-qzm9wgde	41	9	the	the	DT
cord-336510-qzm9wgde	41	10	human	human	JJ
cord-336510-qzm9wgde	41	11	immune	immune	JJ
cord-336510-qzm9wgde	41	12	defence	defence	NN
cord-336510-qzm9wgde	41	13	in	in	IN
cord-336510-qzm9wgde	41	14	a	a	DT
cord-336510-qzm9wgde	41	15	balanced	balanced	JJ
cord-336510-qzm9wgde	41	16	manner	manner	NN
cord-336510-qzm9wgde	41	17	generally	generally	RB
cord-336510-qzm9wgde	41	18	without	without	IN
cord-336510-qzm9wgde	41	19	serious	serious	JJ
cord-336510-qzm9wgde	41	20	threads	thread	NNS
cord-336510-qzm9wgde	41	21	to	to	IN
cord-336510-qzm9wgde	41	22	the	the	DT
cord-336510-qzm9wgde	41	23	life	life	NN
cord-336510-qzm9wgde	41	24	of	of	IN
cord-336510-qzm9wgde	41	25	the	the	DT
cord-336510-qzm9wgde	41	26	host	host	NN
cord-336510-qzm9wgde	41	27	.	.	.
cord-336510-qzm9wgde	42	1	Infection	infection	NN
cord-336510-qzm9wgde	42	2	with	with	IN
cord-336510-qzm9wgde	42	3	a	a	DT
cord-336510-qzm9wgde	42	4	foreign	foreign	JJ
cord-336510-qzm9wgde	42	5	herpesvirus	herpesvirus	NN
cord-336510-qzm9wgde	42	6	,	,	,
cord-336510-qzm9wgde	42	7	normally	normally	RB
cord-336510-qzm9wgde	42	8	hosted	host	VBN
cord-336510-qzm9wgde	42	9	by	by	IN
cord-336510-qzm9wgde	42	10	another	another	DT
cord-336510-qzm9wgde	42	11	species	species	NN
cord-336510-qzm9wgde	42	12	,	,	,
cord-336510-qzm9wgde	42	13	does	do	VBZ
cord-336510-qzm9wgde	42	14	not	not	RB
cord-336510-qzm9wgde	42	15	always	always	RB
cord-336510-qzm9wgde	42	16	hold	hold	VB
cord-336510-qzm9wgde	42	17	this	this	DT
cord-336510-qzm9wgde	42	18	balance	balance	NN
cord-336510-qzm9wgde	42	19	,	,	,
cord-336510-qzm9wgde	42	20	and	and	CC
cord-336510-qzm9wgde	42	21	the	the	DT
cord-336510-qzm9wgde	42	22	pathology	pathology	NN
cord-336510-qzm9wgde	42	23	is	be	VBZ
cord-336510-qzm9wgde	42	24	unpredictable	unpredictable	JJ
cord-336510-qzm9wgde	42	25	.	.	.
cord-336510-qzm9wgde	43	1	This	this	DT
cord-336510-qzm9wgde	43	2	is	be	VBZ
cord-336510-qzm9wgde	43	3	seen	see	VBN
cord-336510-qzm9wgde	43	4	when	when	WRB
cord-336510-qzm9wgde	43	5	humans	human	NNS
cord-336510-qzm9wgde	43	6	are	be	VBP
cord-336510-qzm9wgde	43	7	infected	infect	VBN
cord-336510-qzm9wgde	43	8	with	with	IN
cord-336510-qzm9wgde	43	9	the	the	DT
cord-336510-qzm9wgde	43	10	simian	simian	JJ
cord-336510-qzm9wgde	43	11	B	B	NNP
cord-336510-qzm9wgde	43	12	virus	virus	NN
cord-336510-qzm9wgde	43	13	,	,	,
cord-336510-qzm9wgde	43	14	which	which	WDT
cord-336510-qzm9wgde	43	15	often	often	RB
cord-336510-qzm9wgde	43	16	shows	show	VBZ
cord-336510-qzm9wgde	43	17	serious	serious	JJ
cord-336510-qzm9wgde	43	18	clinical	clinical	JJ
cord-336510-qzm9wgde	43	19	outcome	outcome	NN
cord-336510-qzm9wgde	43	20	[	[	-LRB-
cord-336510-qzm9wgde	43	21	2	2	CD
cord-336510-qzm9wgde	43	22	]	]	-RRB-
cord-336510-qzm9wgde	43	23	.	.	.
cord-336510-qzm9wgde	44	1	The	the	DT
cord-336510-qzm9wgde	44	2	human	human	JJ
cord-336510-qzm9wgde	44	3	herpes	herpes	NN
cord-336510-qzm9wgde	44	4	simplex	simplex	NN
cord-336510-qzm9wgde	44	5	viruses	virus	NNS
cord-336510-qzm9wgde	44	6	were	be	VBD
cord-336510-qzm9wgde	44	7	initially	initially	RB
cord-336510-qzm9wgde	44	8	identified	identify	VBN
cord-336510-qzm9wgde	44	9	by	by	IN
cord-336510-qzm9wgde	44	10	Lowenstein	Lowenstein	NNP
cord-336510-qzm9wgde	44	11	,	,	,
cord-336510-qzm9wgde	44	12	who	who	WP
cord-336510-qzm9wgde	44	13	passed	pass	VBD
cord-336510-qzm9wgde	44	14	it	-PRON-	PRP
cord-336510-qzm9wgde	44	15	onto	onto	IN
cord-336510-qzm9wgde	44	16	rabbits	rabbit	NNS
cord-336510-qzm9wgde	44	17	in	in	IN
cord-336510-qzm9wgde	44	18	1919	1919	CD
cord-336510-qzm9wgde	44	19	,	,	,
cord-336510-qzm9wgde	44	20	and	and	CC
cord-336510-qzm9wgde	44	21	found	find	VBD
cord-336510-qzm9wgde	44	22	it	-PRON-	PRP
cord-336510-qzm9wgde	44	23	to	to	TO
cord-336510-qzm9wgde	44	24	be	be	VB
cord-336510-qzm9wgde	44	25	sensitive	sensitive	JJ
cord-336510-qzm9wgde	44	26	to	to	IN
cord-336510-qzm9wgde	44	27	alcohol	alcohol	NN
cord-336510-qzm9wgde	44	28	and	and	CC
cord-336510-qzm9wgde	44	29	higher	high	JJR
cord-336510-qzm9wgde	44	30	temperatures	temperature	NNS
cord-336510-qzm9wgde	44	31	[	[	-LRB-
cord-336510-qzm9wgde	44	32	3	3	CD
cord-336510-qzm9wgde	44	33	]	]	-RRB-
cord-336510-qzm9wgde	44	34	.	.	.
cord-336510-qzm9wgde	45	1	The	the	DT
cord-336510-qzm9wgde	45	2	viruses	virus	NNS
cord-336510-qzm9wgde	45	3	were	be	VBD
cord-336510-qzm9wgde	45	4	classified	classify	VBN
cord-336510-qzm9wgde	45	5	into	into	IN
cord-336510-qzm9wgde	45	6	two	two	CD
cord-336510-qzm9wgde	45	7	serologically	serologically	RB
cord-336510-qzm9wgde	45	8	different	different	JJ
cord-336510-qzm9wgde	45	9	types	type	NNS
cord-336510-qzm9wgde	45	10	by	by	IN
cord-336510-qzm9wgde	45	11	Schneweiss	Schneweiss	NNP
cord-336510-qzm9wgde	45	12	in	in	IN
cord-336510-qzm9wgde	45	13	1962	1962	CD
cord-336510-qzm9wgde	45	14	[	[	-LRB-
cord-336510-qzm9wgde	45	15	4	4	CD
cord-336510-qzm9wgde	45	16	]	]	-RRB-
cord-336510-qzm9wgde	45	17	,	,	,
cord-336510-qzm9wgde	45	18	and	and	CC
cord-336510-qzm9wgde	45	19	these	these	DT
cord-336510-qzm9wgde	45	20	are	be	VBP
cord-336510-qzm9wgde	45	21	now	now	RB
cord-336510-qzm9wgde	45	22	known	know	VBN
cord-336510-qzm9wgde	45	23	to	to	TO
cord-336510-qzm9wgde	45	24	belong	belong	VB
cord-336510-qzm9wgde	45	25	to	to	IN
cord-336510-qzm9wgde	45	26	the	the	DT
cord-336510-qzm9wgde	45	27	subfamily	subfamily	NN
cord-336510-qzm9wgde	45	28	of	of	IN
cord-336510-qzm9wgde	45	29	Alphaherpes	Alphaherpes	NNP
cord-336510-qzm9wgde	45	30	-	-	HYPH
cord-336510-qzm9wgde	45	31	virinae	virinae	NNP
cord-336510-qzm9wgde	45	32	together	together	RB
cord-336510-qzm9wgde	45	33	with	with	IN
cord-336510-qzm9wgde	45	34	varicella	varicella	NN
cord-336510-qzm9wgde	45	35	-	-	HYPH
cord-336510-qzm9wgde	45	36	zoster	zoster	NN
cord-336510-qzm9wgde	45	37	virus	virus	NN
cord-336510-qzm9wgde	45	38	.	.	.
cord-336510-qzm9wgde	46	1	These	these	DT
cord-336510-qzm9wgde	46	2	alphaherpesviruses	alphaherpesviruse	NNS
cord-336510-qzm9wgde	46	3	all	all	DT
cord-336510-qzm9wgde	46	4	show	show	VBP
cord-336510-qzm9wgde	46	5	neurotropic	neurotropic	NNP
cord-336510-qzm9wgde	46	6	latency	latency	NN
cord-336510-qzm9wgde	46	7	,	,	,
cord-336510-qzm9wgde	46	8	and	and	CC
cord-336510-qzm9wgde	46	9	mucosal	mucosal	JJ
cord-336510-qzm9wgde	46	10	or	or	CC
cord-336510-qzm9wgde	46	11	skin	skin	NN
cord-336510-qzm9wgde	46	12	lesions	lesion	NNS
cord-336510-qzm9wgde	46	13	are	be	VBP
cord-336510-qzm9wgde	46	14	frequently	frequently	RB
cord-336510-qzm9wgde	46	15	seen	see	VBN
cord-336510-qzm9wgde	46	16	as	as	IN
cord-336510-qzm9wgde	46	17	a	a	DT
cord-336510-qzm9wgde	46	18	result	result	NN
cord-336510-qzm9wgde	46	19	of	of	IN
cord-336510-qzm9wgde	46	20	viral	viral	JJ
cord-336510-qzm9wgde	46	21	reactivation	reactivation	NN
cord-336510-qzm9wgde	46	22	from	from	IN
cord-336510-qzm9wgde	46	23	sensory	sensory	JJ
cord-336510-qzm9wgde	46	24	nerves	nerve	NNS
cord-336510-qzm9wgde	46	25	.	.	.
cord-336510-qzm9wgde	47	1	The	the	DT
cord-336510-qzm9wgde	47	2	two	two	CD
cord-336510-qzm9wgde	47	3	types	type	NNS
cord-336510-qzm9wgde	47	4	of	of	IN
cord-336510-qzm9wgde	47	5	herpes	herpe	NNS
cord-336510-qzm9wgde	47	6	simplex	simplex	NNP
cord-336510-qzm9wgde	47	7	virus	virus	NN
cord-336510-qzm9wgde	47	8	confer	confer	VBP
cord-336510-qzm9wgde	47	9	the	the	DT
cord-336510-qzm9wgde	47	10	genera	genera	NNP
cord-336510-qzm9wgde	47	11	Simplexvirus	Simplexvirus	NNP
cord-336510-qzm9wgde	47	12	1	1	CD
cord-336510-qzm9wgde	47	13	and	and	CC
cord-336510-qzm9wgde	47	14	-2	-2	NNP
cord-336510-qzm9wgde	47	15	,	,	,
cord-336510-qzm9wgde	47	16	which	which	WDT
cord-336510-qzm9wgde	47	17	were	be	VBD
cord-336510-qzm9wgde	47	18	formally	formally	RB
cord-336510-qzm9wgde	47	19	designated	designate	VBN
cord-336510-qzm9wgde	47	20	by	by	IN
cord-336510-qzm9wgde	47	21	the	the	DT
cord-336510-qzm9wgde	47	22	International	International	NNP
cord-336510-qzm9wgde	47	23	Committee	Committee	NNP
cord-336510-qzm9wgde	47	24	on	on	IN
cord-336510-qzm9wgde	47	25	Taxonomy	Taxonomy	NNP
cord-336510-qzm9wgde	47	26	of	of	IN
cord-336510-qzm9wgde	47	27	Viruses	Viruses	NNPS
cord-336510-qzm9wgde	47	28	as	as	IN
cord-336510-qzm9wgde	47	29	Human	human	JJ
cord-336510-qzm9wgde	47	30	herpesvirus	herpesvirus	NN
cord-336510-qzm9wgde	47	31	(	(	-LRB-
cord-336510-qzm9wgde	47	32	HHV	HHV	NNP
cord-336510-qzm9wgde	47	33	)	)	-RRB-
cord-336510-qzm9wgde	47	34	1	1	CD
cord-336510-qzm9wgde	47	35	and	and	CC
cord-336510-qzm9wgde	47	36	2	2	CD
cord-336510-qzm9wgde	47	37	[	[	-LRB-
cord-336510-qzm9wgde	47	38	5	5	CD
cord-336510-qzm9wgde	47	39	]	]	-RRB-
cord-336510-qzm9wgde	47	40	.	.	.
cord-336510-qzm9wgde	48	1	Herpes	Herpes	NNP
cord-336510-qzm9wgde	48	2	simplex	simplex	NN
cord-336510-qzm9wgde	48	3	virus	virus	NN
cord-336510-qzm9wgde	48	4	(	(	-LRB-
cord-336510-qzm9wgde	48	5	HSV	HSV	NNP
cord-336510-qzm9wgde	48	6	)	)	-RRB-
cord-336510-qzm9wgde	48	7	type	type	NN
cord-336510-qzm9wgde	48	8	1	1	CD
cord-336510-qzm9wgde	48	9	and	and	CC
cord-336510-qzm9wgde	48	10	type	type	NN
cord-336510-qzm9wgde	48	11	2	2	CD
cord-336510-qzm9wgde	48	12	are	be	VBP
cord-336510-qzm9wgde	48	13	very	very	RB
cord-336510-qzm9wgde	48	14	closely	closely	RB
cord-336510-qzm9wgde	48	15	related	related	JJ
cord-336510-qzm9wgde	48	16	,	,	,
cord-336510-qzm9wgde	48	17	showing	show	VBG
cord-336510-qzm9wgde	48	18	a	a	DT
cord-336510-qzm9wgde	48	19	homology	homology	NN
cord-336510-qzm9wgde	48	20	at	at	IN
cord-336510-qzm9wgde	48	21	the	the	DT
cord-336510-qzm9wgde	48	22	DNA	dna	NN
cord-336510-qzm9wgde	48	23	level	level	NN
cord-336510-qzm9wgde	48	24	of	of	IN
cord-336510-qzm9wgde	48	25	83	83	CD
cord-336510-qzm9wgde	48	26	%	%	NN
cord-336510-qzm9wgde	48	27	in	in	IN
cord-336510-qzm9wgde	48	28	protein	protein	NN
cord-336510-qzm9wgde	48	29	coding	coding	NN
cord-336510-qzm9wgde	48	30	regions	region	NNS
cord-336510-qzm9wgde	48	31	and	and	CC
cord-336510-qzm9wgde	48	32	less	less	RBR
cord-336510-qzm9wgde	48	33	in	in	IN
cord-336510-qzm9wgde	48	34	noncoding	noncoding	JJ
cord-336510-qzm9wgde	48	35	regions	region	NNS
cord-336510-qzm9wgde	48	36	[	[	-LRB-
cord-336510-qzm9wgde	48	37	6	6	CD
cord-336510-qzm9wgde	48	38	]	]	-RRB-
cord-336510-qzm9wgde	48	39	.	.	.
cord-336510-qzm9wgde	49	1	The	the	DT
cord-336510-qzm9wgde	49	2	genetic	genetic	JJ
cord-336510-qzm9wgde	49	3	map	map	NN
cord-336510-qzm9wgde	49	4	of	of	IN
cord-336510-qzm9wgde	49	5	the	the	DT
cord-336510-qzm9wgde	49	6	two	two	CD
cord-336510-qzm9wgde	49	7	herpes	herpe	NNS
cord-336510-qzm9wgde	49	8	simplex	simplex	NN
cord-336510-qzm9wgde	49	9	viruses	virus	NNS
cord-336510-qzm9wgde	49	10	is	be	VBZ
cord-336510-qzm9wgde	49	11	colinear	colinear	JJ
cord-336510-qzm9wgde	49	12	[	[	-LRB-
cord-336510-qzm9wgde	49	13	6	6	CD
cord-336510-qzm9wgde	49	14	]	]	-RRB-
cord-336510-qzm9wgde	49	15	,	,	,
cord-336510-qzm9wgde	49	16	and	and	CC
cord-336510-qzm9wgde	49	17	the	the	DT
cord-336510-qzm9wgde	49	18	genomes	genome	NNS
cord-336510-qzm9wgde	49	19	are	be	VBP
cord-336510-qzm9wgde	49	20	of	of	IN
cord-336510-qzm9wgde	49	21	approximately	approximately	RB
cord-336510-qzm9wgde	49	22	the	the	DT
cord-336510-qzm9wgde	49	23	same	same	JJ
cord-336510-qzm9wgde	49	24	size	size	NN
cord-336510-qzm9wgde	49	25	,	,	,
cord-336510-qzm9wgde	49	26	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	49	27	of	of	IN
cord-336510-qzm9wgde	49	28	152	152	CD
cord-336510-qzm9wgde	49	29	kbp	kbp	NNP
cord-336510-qzm9wgde	49	30	[	[	-LRB-
cord-336510-qzm9wgde	49	31	7	7	CD
cord-336510-qzm9wgde	49	32	]	]	-RRB-
cord-336510-qzm9wgde	49	33	and	and	CC
cord-336510-qzm9wgde	49	34	HSV-2	HSV-2	NNPS
cord-336510-qzm9wgde	49	35	of	of	IN
cord-336510-qzm9wgde	49	36	155	155	CD
cord-336510-qzm9wgde	49	37	kbp	kbp	NNS
cord-336510-qzm9wgde	49	38	,	,	,
cord-336510-qzm9wgde	49	39	and	and	CC
cord-336510-qzm9wgde	49	40	code	code	NN
cord-336510-qzm9wgde	49	41	for	for	IN
cord-336510-qzm9wgde	49	42	corresponding	corresponding	JJ
cord-336510-qzm9wgde	49	43	genes	gene	NNS
cord-336510-qzm9wgde	49	44	[	[	-LRB-
cord-336510-qzm9wgde	49	45	6	6	CD
cord-336510-qzm9wgde	49	46	]	]	-RRB-
cord-336510-qzm9wgde	49	47	.	.	.
cord-336510-qzm9wgde	50	1	The	the	DT
cord-336510-qzm9wgde	50	2	minor	minor	JJ
cord-336510-qzm9wgde	50	3	sequence	sequence	NN
cord-336510-qzm9wgde	50	4	variations	variation	NNS
cord-336510-qzm9wgde	50	5	give	give	VBP
cord-336510-qzm9wgde	50	6	different	different	JJ
cord-336510-qzm9wgde	50	7	cleavage	cleavage	NN
cord-336510-qzm9wgde	50	8	sites	site	NNS
cord-336510-qzm9wgde	50	9	for	for	IN
cord-336510-qzm9wgde	50	10	restriction	restriction	NN
cord-336510-qzm9wgde	50	11	endonucleases	endonuclease	NNS
cord-336510-qzm9wgde	50	12	,	,	,
cord-336510-qzm9wgde	50	13	which	which	WDT
cord-336510-qzm9wgde	50	14	has	have	VBZ
cord-336510-qzm9wgde	50	15	been	be	VBN
cord-336510-qzm9wgde	50	16	used	use	VBN
cord-336510-qzm9wgde	50	17	intensively	intensively	RB
cord-336510-qzm9wgde	50	18	as	as	IN
cord-336510-qzm9wgde	50	19	an	an	DT
cord-336510-qzm9wgde	50	20	important	important	JJ
cord-336510-qzm9wgde	50	21	epidemiological	epidemiological	JJ
cord-336510-qzm9wgde	50	22	tool	tool	NN
cord-336510-qzm9wgde	50	23	[	[	-LRB-
cord-336510-qzm9wgde	50	24	8	8	CD
cord-336510-qzm9wgde	50	25	]	]	-RRB-
cord-336510-qzm9wgde	50	26	[	[	-LRB-
cord-336510-qzm9wgde	50	27	9	9	CD
cord-336510-qzm9wgde	50	28	]	]	-RRB-
cord-336510-qzm9wgde	50	29	[	[	-LRB-
cord-336510-qzm9wgde	50	30	10	10	CD
cord-336510-qzm9wgde	50	31	]	]	-RRB-
cord-336510-qzm9wgde	50	32	.	.	.
cord-336510-qzm9wgde	51	1	As	as	IN
cord-336510-qzm9wgde	51	2	all	all	DT
cord-336510-qzm9wgde	51	3	other	other	JJ
cord-336510-qzm9wgde	51	4	herpesviruses	herpesviruse	NNS
cord-336510-qzm9wgde	51	5	the	the	DT
cord-336510-qzm9wgde	51	6	herpes	herpes	NN
cord-336510-qzm9wgde	51	7	simplex	simplex	NN
cord-336510-qzm9wgde	51	8	viruses	virus	NNS
cord-336510-qzm9wgde	51	9	are	be	VBP
cord-336510-qzm9wgde	51	10	enveloped	envelop	VBN
cord-336510-qzm9wgde	51	11	,	,	,
cord-336510-qzm9wgde	51	12	icosahedral	icosahedral	JJ
cord-336510-qzm9wgde	51	13	DNA	dna	NN
cord-336510-qzm9wgde	51	14	viruses	virus	NNS
cord-336510-qzm9wgde	51	15	with	with	IN
cord-336510-qzm9wgde	51	16	a	a	DT
cord-336510-qzm9wgde	51	17	capsid	capsid	NN
cord-336510-qzm9wgde	51	18	of	of	IN
cord-336510-qzm9wgde	51	19	approximately	approximately	RB
cord-336510-qzm9wgde	51	20	100	100	CD
cord-336510-qzm9wgde	51	21	nm	nm	NN
cord-336510-qzm9wgde	51	22	(	(	-LRB-
cord-336510-qzm9wgde	51	23	fig	fig	NN
cord-336510-qzm9wgde	51	24	.	.	.
cord-336510-qzm9wgde	51	25	1	1	CD
cord-336510-qzm9wgde	51	26	)	)	-RRB-
cord-336510-qzm9wgde	52	1	[	[	-LRB-
cord-336510-qzm9wgde	52	2	1	1	CD
cord-336510-qzm9wgde	52	3	]	]	-RRB-
cord-336510-qzm9wgde	52	4	.	.	.
cord-336510-qzm9wgde	53	1	The	the	DT
cord-336510-qzm9wgde	53	2	envelope	envelope	NN
cord-336510-qzm9wgde	53	3	holds	hold	VBZ
cord-336510-qzm9wgde	53	4	at	at	RB
cord-336510-qzm9wgde	53	5	least	least	RBS
cord-336510-qzm9wgde	53	6	10	10	CD
cord-336510-qzm9wgde	53	7	different	different	JJ
cord-336510-qzm9wgde	53	8	glycoproteins	glycoprotein	NNS
cord-336510-qzm9wgde	53	9	protruding	protrude	VBG
cord-336510-qzm9wgde	53	10	from	from	IN
cord-336510-qzm9wgde	53	11	the	the	DT
cord-336510-qzm9wgde	53	12	outer	outer	JJ
cord-336510-qzm9wgde	53	13	side	side	NN
cord-336510-qzm9wgde	53	14	(	(	-LRB-
cord-336510-qzm9wgde	53	15	gB	gB	NNP
cord-336510-qzm9wgde	53	16	,	,	,
cord-336510-qzm9wgde	53	17	gC	gC	NNP
cord-336510-qzm9wgde	53	18	,	,	,
cord-336510-qzm9wgde	53	19	gD	gD	NNP
cord-336510-qzm9wgde	53	20	,	,	,
cord-336510-qzm9wgde	53	21	gE	gE	NNP
cord-336510-qzm9wgde	53	22	,	,	,
cord-336510-qzm9wgde	53	23	gG	gG	NNP
cord-336510-qzm9wgde	53	24	,	,	,
cord-336510-qzm9wgde	53	25	gH	gH	NNP
cord-336510-qzm9wgde	53	26	,	,	,
cord-336510-qzm9wgde	53	27	gI	gI	NNP
cord-336510-qzm9wgde	53	28	,	,	,
cord-336510-qzm9wgde	53	29	gK	gk	UH
cord-336510-qzm9wgde	53	30	,	,	,
cord-336510-qzm9wgde	53	31	gL	gL	NNP
cord-336510-qzm9wgde	53	32	,	,	,
cord-336510-qzm9wgde	53	33	and	and	CC
cord-336510-qzm9wgde	53	34	gM	gM	NNP
cord-336510-qzm9wgde	53	35	)	)	-RRB-
cord-336510-qzm9wgde	53	36	.	.	.
cord-336510-qzm9wgde	54	1	The	the	DT
cord-336510-qzm9wgde	54	2	glycoproteins	glycoprotein	NNS
cord-336510-qzm9wgde	54	3	are	be	VBP
cord-336510-qzm9wgde	54	4	primarily	primarily	RB
cord-336510-qzm9wgde	54	5	responsible	responsible	JJ
cord-336510-qzm9wgde	54	6	for	for	IN
cord-336510-qzm9wgde	54	7	attachment	attachment	NN
cord-336510-qzm9wgde	54	8	to	to	IN
cord-336510-qzm9wgde	54	9	cellular	cellular	JJ
cord-336510-qzm9wgde	54	10	receptors	receptor	NNS
cord-336510-qzm9wgde	54	11	and	and	CC
cord-336510-qzm9wgde	54	12	fusion	fusion	NN
cord-336510-qzm9wgde	54	13	of	of	IN
cord-336510-qzm9wgde	54	14	membranes	membrane	NNS
cord-336510-qzm9wgde	54	15	(	(	-LRB-
cord-336510-qzm9wgde	54	16	especially	especially	RB
cord-336510-qzm9wgde	54	17	gB	gB	NNP
cord-336510-qzm9wgde	54	18	and	and	CC
cord-336510-qzm9wgde	54	19	gD	gD	NNP
cord-336510-qzm9wgde	54	20	)	)	-RRB-
cord-336510-qzm9wgde	55	1	[	[	-LRB-
cord-336510-qzm9wgde	55	2	11	11	CD
cord-336510-qzm9wgde	55	3	]	]	-RRB-
cord-336510-qzm9wgde	55	4	[	[	-LRB-
cord-336510-qzm9wgde	55	5	12	12	CD
cord-336510-qzm9wgde	55	6	]	]	-RRB-
cord-336510-qzm9wgde	55	7	[	[	-LRB-
cord-336510-qzm9wgde	55	8	13	13	CD
cord-336510-qzm9wgde	55	9	]	]	-RRB-
cord-336510-qzm9wgde	56	1	[	[	-LRB-
cord-336510-qzm9wgde	56	2	14	14	CD
cord-336510-qzm9wgde	56	3	]	]	-RRB-
cord-336510-qzm9wgde	56	4	.	.	.
cord-336510-qzm9wgde	57	1	In	in	IN
cord-336510-qzm9wgde	57	2	addition	addition	NN
cord-336510-qzm9wgde	57	3	,	,	,
cord-336510-qzm9wgde	57	4	there	there	EX
cord-336510-qzm9wgde	57	5	are	be	VBP
cord-336510-qzm9wgde	57	6	two	two	CD
cord-336510-qzm9wgde	57	7	unglycosylated	unglycosylated	JJ
cord-336510-qzm9wgde	57	8	proteins	protein	NNS
cord-336510-qzm9wgde	57	9	in	in	IN
cord-336510-qzm9wgde	57	10	the	the	DT
cord-336510-qzm9wgde	57	11	viral	viral	JJ
cord-336510-qzm9wgde	57	12	envelope	envelope	NN
cord-336510-qzm9wgde	57	13	.	.	.
cord-336510-qzm9wgde	58	1	The	the	DT
cord-336510-qzm9wgde	58	2	glycoproteins	glycoprotein	NNS
cord-336510-qzm9wgde	58	3	of	of	IN
cord-336510-qzm9wgde	58	4	the	the	DT
cord-336510-qzm9wgde	58	5	envelope	envelope	NN
cord-336510-qzm9wgde	58	6	have	have	VBP
cord-336510-qzm9wgde	58	7	several	several	JJ
cord-336510-qzm9wgde	58	8	immunoregulatory	immunoregulatory	JJ
cord-336510-qzm9wgde	58	9	effects	effect	NNS
cord-336510-qzm9wgde	58	10	besides	besides	IN
cord-336510-qzm9wgde	58	11	their	-PRON-	PRP$
cord-336510-qzm9wgde	58	12	primary	primary	JJ
cord-336510-qzm9wgde	58	13	more	more	RBR
cord-336510-qzm9wgde	58	14	mechanical	mechanical	JJ
cord-336510-qzm9wgde	58	15	functions	function	NNS
cord-336510-qzm9wgde	58	16	in	in	IN
cord-336510-qzm9wgde	58	17	viral	viral	JJ
cord-336510-qzm9wgde	58	18	attachment	attachment	NN
cord-336510-qzm9wgde	58	19	and	and	CC
cord-336510-qzm9wgde	58	20	entry	entry	NN
cord-336510-qzm9wgde	58	21	[	[	-LRB-
cord-336510-qzm9wgde	58	22	15	15	CD
cord-336510-qzm9wgde	58	23	]	]	-RRB-
cord-336510-qzm9wgde	58	24	[	[	-LRB-
cord-336510-qzm9wgde	58	25	16	16	CD
cord-336510-qzm9wgde	58	26	]	]	-RRB-
cord-336510-qzm9wgde	58	27	[	[	-LRB-
cord-336510-qzm9wgde	58	28	17	17	CD
cord-336510-qzm9wgde	58	29	]	]	-RRB-
cord-336510-qzm9wgde	58	30	[	[	-LRB-
cord-336510-qzm9wgde	58	31	18	18	CD
cord-336510-qzm9wgde	58	32	]	]	-RRB-
cord-336510-qzm9wgde	58	33	[	[	-LRB-
cord-336510-qzm9wgde	58	34	19	19	CD
cord-336510-qzm9wgde	58	35	]	]	-RRB-
cord-336510-qzm9wgde	58	36	.	.	.
cord-336510-qzm9wgde	59	1	In	in	IN
cord-336510-qzm9wgde	59	2	the	the	DT
cord-336510-qzm9wgde	59	3	space	space	NN
cord-336510-qzm9wgde	59	4	between	between	IN
cord-336510-qzm9wgde	59	5	the	the	DT
cord-336510-qzm9wgde	59	6	envelope	envelope	NN
cord-336510-qzm9wgde	59	7	and	and	CC
cord-336510-qzm9wgde	59	8	the	the	DT
cord-336510-qzm9wgde	59	9	capsid	capsid	NN
cord-336510-qzm9wgde	59	10	,	,	,
cord-336510-qzm9wgde	59	11	the	the	DT
cord-336510-qzm9wgde	59	12	complete	complete	JJ
cord-336510-qzm9wgde	59	13	viral	viral	JJ
cord-336510-qzm9wgde	59	14	particles	particle	NNS
cord-336510-qzm9wgde	59	15	posses	posse	VBZ
cord-336510-qzm9wgde	59	16	an	an	DT
cord-336510-qzm9wgde	59	17	almost	almost	RB
cord-336510-qzm9wgde	59	18	amorphous	amorphous	JJ
cord-336510-qzm9wgde	59	19	structure	structure	NN
cord-336510-qzm9wgde	59	20	which	which	WDT
cord-336510-qzm9wgde	59	21	was	be	VBD
cord-336510-qzm9wgde	59	22	termed	term	VBN
cord-336510-qzm9wgde	59	23	the	the	DT
cord-336510-qzm9wgde	59	24	tegument	tegument	NN
cord-336510-qzm9wgde	59	25	by	by	IN
cord-336510-qzm9wgde	59	26	Roizman	Roizman	NNP
cord-336510-qzm9wgde	59	27	and	and	CC
cord-336510-qzm9wgde	59	28	Furlong	Furlong	NNP
cord-336510-qzm9wgde	59	29	[	[	-LRB-
cord-336510-qzm9wgde	59	30	20	20	CD
cord-336510-qzm9wgde	59	31	]	]	-RRB-
cord-336510-qzm9wgde	59	32	.	.	.
cord-336510-qzm9wgde	60	1	The	the	DT
cord-336510-qzm9wgde	60	2	tegument	tegument	NN
cord-336510-qzm9wgde	60	3	consists	consist	VBZ
cord-336510-qzm9wgde	60	4	of	of	IN
cord-336510-qzm9wgde	60	5	several	several	JJ
cord-336510-qzm9wgde	60	6	viral	viral	JJ
cord-336510-qzm9wgde	60	7	proteins	protein	NNS
cord-336510-qzm9wgde	60	8	involved	involve	VBN
cord-336510-qzm9wgde	60	9	in	in	IN
cord-336510-qzm9wgde	60	10	the	the	DT
cord-336510-qzm9wgde	60	11	initial	initial	JJ
cord-336510-qzm9wgde	60	12	phases	phase	NNS
cord-336510-qzm9wgde	60	13	of	of	IN
cord-336510-qzm9wgde	60	14	viral	viral	JJ
cord-336510-qzm9wgde	60	15	infection	infection	NN
cord-336510-qzm9wgde	60	16	and	and	CC
cord-336510-qzm9wgde	60	17	replication	replication	NN
cord-336510-qzm9wgde	60	18	such	such	JJ
cord-336510-qzm9wgde	60	19	as	as	IN
cord-336510-qzm9wgde	60	20	transport	transport	NN
cord-336510-qzm9wgde	60	21	of	of	IN
cord-336510-qzm9wgde	60	22	the	the	DT
cord-336510-qzm9wgde	60	23	viral	viral	JJ
cord-336510-qzm9wgde	60	24	DNA	dna	NN
cord-336510-qzm9wgde	60	25	out	out	IN
cord-336510-qzm9wgde	60	26	of	of	IN
cord-336510-qzm9wgde	60	27	the	the	DT
cord-336510-qzm9wgde	60	28	capsid	capsid	NN
cord-336510-qzm9wgde	60	29	[	[	-LRB-
cord-336510-qzm9wgde	60	30	21	21	CD
cord-336510-qzm9wgde	60	31	]	]	-RRB-
cord-336510-qzm9wgde	60	32	,	,	,
cord-336510-qzm9wgde	60	33	early	early	JJ
cord-336510-qzm9wgde	60	34	shutoff	shutoff	NN
cord-336510-qzm9wgde	60	35	of	of	IN
cord-336510-qzm9wgde	60	36	cellular	cellular	JJ
cord-336510-qzm9wgde	60	37	protein	protein	NN
cord-336510-qzm9wgde	60	38	synthesis	synthesis	NN
cord-336510-qzm9wgde	60	39	(	(	-LRB-
cord-336510-qzm9wgde	60	40	vhs	vhs	NNP
cord-336510-qzm9wgde	60	41	)	)	-RRB-
cord-336510-qzm9wgde	60	42	[	[	-LRB-
cord-336510-qzm9wgde	60	43	22	22	CD
cord-336510-qzm9wgde	60	44	]	]	-RRB-
cord-336510-qzm9wgde	60	45	,	,	,
cord-336510-qzm9wgde	60	46	and	and	CC
cord-336510-qzm9wgde	60	47	initiation	initiation	NN
cord-336510-qzm9wgde	60	48	of	of	IN
cord-336510-qzm9wgde	60	49	transcription	transcription	NN
cord-336510-qzm9wgde	60	50	of	of	IN
cord-336510-qzm9wgde	60	51	viral	viral	JJ
cord-336510-qzm9wgde	60	52	genes	gene	NNS
cord-336510-qzm9wgde	60	53	(	(	-LRB-
cord-336510-qzm9wgde	60	54	α	α	NN
cord-336510-qzm9wgde	60	55	-	-	HYPH
cord-336510-qzm9wgde	60	56	trans	trans	NN
cord-336510-qzm9wgde	60	57	-	-	JJ
cord-336510-qzm9wgde	60	58	inducing	inducing	JJ
cord-336510-qzm9wgde	60	59	factors	factor	NNS
cord-336510-qzm9wgde	60	60	)	)	-RRB-
cord-336510-qzm9wgde	61	1	[	[	-LRB-
cord-336510-qzm9wgde	61	2	23	23	CD
cord-336510-qzm9wgde	61	3	]	]	-RRB-
cord-336510-qzm9wgde	61	4	.	.	.
cord-336510-qzm9wgde	62	1	Besides	besides	IN
cord-336510-qzm9wgde	62	2	the	the	DT
cord-336510-qzm9wgde	62	3	tegument	tegument	NN
cord-336510-qzm9wgde	62	4	seen	see	VBN
cord-336510-qzm9wgde	62	5	in	in	IN
cord-336510-qzm9wgde	62	6	complete	complete	JJ
cord-336510-qzm9wgde	62	7	viral	viral	JJ
cord-336510-qzm9wgde	62	8	particles	particle	NNS
cord-336510-qzm9wgde	62	9	,	,	,
cord-336510-qzm9wgde	62	10	tegument	tegument	NN
cord-336510-qzm9wgde	62	11	-	-	HYPH
cord-336510-qzm9wgde	62	12	like	like	JJ
cord-336510-qzm9wgde	62	13	structures	structure	NNS
cord-336510-qzm9wgde	62	14	are	be	VBP
cord-336510-qzm9wgde	62	15	seen	see	VBN
cord-336510-qzm9wgde	62	16	in	in	IN
cord-336510-qzm9wgde	62	17	enveloped	envelop	VBN
cord-336510-qzm9wgde	62	18	particles	particle	NNS
cord-336510-qzm9wgde	62	19	lacking	lack	VBG
cord-336510-qzm9wgde	62	20	a	a	DT
cord-336510-qzm9wgde	62	21	capsid	capsid	NN
cord-336510-qzm9wgde	62	22	and	and	CC
cord-336510-qzm9wgde	62	23	DNA	dna	NN
cord-336510-qzm9wgde	62	24	,	,	,
cord-336510-qzm9wgde	62	25	the	the	DT
cord-336510-qzm9wgde	62	26	so	so	RB
cord-336510-qzm9wgde	62	27	called	call	VBN
cord-336510-qzm9wgde	62	28	light	light	JJ
cord-336510-qzm9wgde	62	29	particles	particle	NNS
cord-336510-qzm9wgde	62	30	[	[	-LRB-
cord-336510-qzm9wgde	62	31	24	24	CD
cord-336510-qzm9wgde	62	32	,	,	,
cord-336510-qzm9wgde	62	33	25	25	CD
cord-336510-qzm9wgde	62	34	]	]	-RRB-
cord-336510-qzm9wgde	62	35	.	.	.
cord-336510-qzm9wgde	63	1	The	the	DT
cord-336510-qzm9wgde	63	2	capsid	capsid	NN
cord-336510-qzm9wgde	63	3	is	be	VBZ
cord-336510-qzm9wgde	63	4	composed	compose	VBN
cord-336510-qzm9wgde	63	5	of	of	IN
cord-336510-qzm9wgde	63	6	a	a	DT
cord-336510-qzm9wgde	63	7	complex	complex	JJ
cord-336510-qzm9wgde	63	8	icosahedral	icosahedral	JJ
cord-336510-qzm9wgde	63	9	structure	structure	NN
cord-336510-qzm9wgde	63	10	of	of	IN
cord-336510-qzm9wgde	63	11	162	162	CD
cord-336510-qzm9wgde	63	12	capsomeres	capsomere	NNS
cord-336510-qzm9wgde	63	13	,	,	,
cord-336510-qzm9wgde	63	14	each	each	DT
cord-336510-qzm9wgde	63	15	with	with	IN
cord-336510-qzm9wgde	63	16	a	a	DT
cord-336510-qzm9wgde	63	17	central	central	JJ
cord-336510-qzm9wgde	63	18	channel	channel	NN
cord-336510-qzm9wgde	63	19	running	run	VBG
cord-336510-qzm9wgde	63	20	from	from	IN
cord-336510-qzm9wgde	63	21	the	the	DT
cord-336510-qzm9wgde	63	22	outside	outside	NN
cord-336510-qzm9wgde	63	23	to	to	IN
cord-336510-qzm9wgde	63	24	the	the	DT
cord-336510-qzm9wgde	63	25	interior	interior	NN
cord-336510-qzm9wgde	63	26	of	of	IN
cord-336510-qzm9wgde	63	27	the	the	DT
cord-336510-qzm9wgde	63	28	capsid	capsid	NN
cord-336510-qzm9wgde	63	29	.	.	.
cord-336510-qzm9wgde	64	1	Inside	inside	IN
cord-336510-qzm9wgde	64	2	the	the	DT
cord-336510-qzm9wgde	64	3	capsid	capsid	NN
cord-336510-qzm9wgde	64	4	the	the	DT
cord-336510-qzm9wgde	64	5	double	double	JJ
cord-336510-qzm9wgde	64	6	stranded	strand	VBN
cord-336510-qzm9wgde	64	7	linear	linear	JJ
cord-336510-qzm9wgde	64	8	DNA	DNA	NNP
cord-336510-qzm9wgde	64	9	is	be	VBZ
cord-336510-qzm9wgde	64	10	packed	pack	VBN
cord-336510-qzm9wgde	64	11	as	as	IN
cord-336510-qzm9wgde	64	12	a	a	DT
cord-336510-qzm9wgde	64	13	spool	spool	NN
cord-336510-qzm9wgde	64	14	with	with	IN
cord-336510-qzm9wgde	64	15	the	the	DT
cord-336510-qzm9wgde	64	16	ends	end	NNS
cord-336510-qzm9wgde	64	17	in	in	IN
cord-336510-qzm9wgde	64	18	close	close	JJ
cord-336510-qzm9wgde	64	19	proximity	proximity	NN
cord-336510-qzm9wgde	64	20	[	[	-LRB-
cord-336510-qzm9wgde	64	21	21	21	CD
cord-336510-qzm9wgde	64	22	,	,	,
cord-336510-qzm9wgde	64	23	26	26	CD
cord-336510-qzm9wgde	64	24	,	,	,
cord-336510-qzm9wgde	64	25	27	27	CD
cord-336510-qzm9wgde	64	26	]	]	-RRB-
cord-336510-qzm9wgde	64	27	.	.	.
cord-336510-qzm9wgde	65	1	The	the	DT
cord-336510-qzm9wgde	65	2	genome	genome	NN
cord-336510-qzm9wgde	65	3	consists	consist	VBZ
cord-336510-qzm9wgde	65	4	of	of	IN
cord-336510-qzm9wgde	65	5	a	a	DT
cord-336510-qzm9wgde	65	6	long	long	JJ
cord-336510-qzm9wgde	65	7	(	(	-LRB-
cord-336510-qzm9wgde	65	8	L	l	NN
cord-336510-qzm9wgde	65	9	)	)	-RRB-
cord-336510-qzm9wgde	65	10	and	and	CC
cord-336510-qzm9wgde	65	11	a	a	DT
cord-336510-qzm9wgde	65	12	short	short	JJ
cord-336510-qzm9wgde	65	13	(	(	-LRB-
cord-336510-qzm9wgde	65	14	S	s	NN
cord-336510-qzm9wgde	65	15	)	)	-RRB-
cord-336510-qzm9wgde	65	16	segment	segment	NN
cord-336510-qzm9wgde	65	17	which	which	WDT
cord-336510-qzm9wgde	65	18	are	be	VBP
cord-336510-qzm9wgde	65	19	covalently	covalently	RB
cord-336510-qzm9wgde	65	20	linked	link	VBN
cord-336510-qzm9wgde	65	21	[	[	-LRB-
cord-336510-qzm9wgde	65	22	28	28	CD
cord-336510-qzm9wgde	65	23	]	]	-RRB-
cord-336510-qzm9wgde	65	24	,	,	,
cord-336510-qzm9wgde	65	25	and	and	CC
cord-336510-qzm9wgde	65	26	contains	contain	VBZ
cord-336510-qzm9wgde	65	27	a	a	DT
cord-336510-qzm9wgde	65	28	high	high	JJ
cord-336510-qzm9wgde	65	29	density	density	NN
cord-336510-qzm9wgde	65	30	of	of	IN
cord-336510-qzm9wgde	65	31	genetic	genetic	JJ
cord-336510-qzm9wgde	65	32	information	information	NN
cord-336510-qzm9wgde	65	33	with	with	IN
cord-336510-qzm9wgde	65	34	about	about	RB
cord-336510-qzm9wgde	65	35	94	94	CD
cord-336510-qzm9wgde	65	36	open	open	JJ
cord-336510-qzm9wgde	65	37	reading	reading	NN
cord-336510-qzm9wgde	65	38	frames	frame	NNS
cord-336510-qzm9wgde	65	39	(	(	-LRB-
cord-336510-qzm9wgde	65	40	ORF	ORF	NNP
cord-336510-qzm9wgde	65	41	)	)	-RRB-
cord-336510-qzm9wgde	65	42	and	and	CC
cord-336510-qzm9wgde	65	43	encodes	encode	VBZ
cord-336510-qzm9wgde	65	44	approximately	approximately	RB
cord-336510-qzm9wgde	65	45	84	84	CD
cord-336510-qzm9wgde	65	46	polypeptides	polypeptide	NNS
cord-336510-qzm9wgde	65	47	[	[	-LRB-
cord-336510-qzm9wgde	65	48	7	7	CD
cord-336510-qzm9wgde	65	49	,	,	,
cord-336510-qzm9wgde	65	50	29	29	CD
cord-336510-qzm9wgde	65	51	]	]	-RRB-
cord-336510-qzm9wgde	65	52	,	,	,
cord-336510-qzm9wgde	65	53	of	of	IN
cord-336510-qzm9wgde	65	54	which	which	WDT
cord-336510-qzm9wgde	65	55	only	only	RB
cord-336510-qzm9wgde	65	56	37	37	CD
cord-336510-qzm9wgde	65	57	are	be	VBP
cord-336510-qzm9wgde	65	58	required	require	VBN
cord-336510-qzm9wgde	65	59	for	for	IN
cord-336510-qzm9wgde	65	60	replication	replication	NN
cord-336510-qzm9wgde	65	61	of	of	IN
cord-336510-qzm9wgde	65	62	the	the	DT
cord-336510-qzm9wgde	65	63	virus	virus	NN
cord-336510-qzm9wgde	65	64	in	in	IN
cord-336510-qzm9wgde	65	65	cultured	cultured	JJ
cord-336510-qzm9wgde	65	66	cells	cell	NNS
cord-336510-qzm9wgde	65	67	[	[	-LRB-
cord-336510-qzm9wgde	65	68	30	30	CD
cord-336510-qzm9wgde	65	69	,	,	,
cord-336510-qzm9wgde	65	70	31	31	CD
cord-336510-qzm9wgde	65	71	]	]	-RRB-
cord-336510-qzm9wgde	65	72	.	.	.
cord-336510-qzm9wgde	66	1	The	the	DT
cord-336510-qzm9wgde	66	2	viral	viral	JJ
cord-336510-qzm9wgde	66	3	genes	gene	NNS
cord-336510-qzm9wgde	66	4	are	be	VBP
cord-336510-qzm9wgde	66	5	expressed	express	VBN
cord-336510-qzm9wgde	66	6	in	in	IN
cord-336510-qzm9wgde	66	7	a	a	DT
cord-336510-qzm9wgde	66	8	cascade	cascade	NN
cord-336510-qzm9wgde	66	9	in	in	IN
cord-336510-qzm9wgde	66	10	groups	group	NNS
cord-336510-qzm9wgde	66	11	classified	classify	VBN
cord-336510-qzm9wgde	66	12	as	as	IN
cord-336510-qzm9wgde	66	13	immediate	immediate	JJ
cord-336510-qzm9wgde	66	14	early	early	JJ
cord-336510-qzm9wgde	66	15	(	(	-LRB-
cord-336510-qzm9wgde	66	16	IE	IE	NNP
cord-336510-qzm9wgde	66	17	,	,	,
cord-336510-qzm9wgde	66	18	α	α	NN
cord-336510-qzm9wgde	66	19	)	)	-RRB-
cord-336510-qzm9wgde	66	20	,	,	,
cord-336510-qzm9wgde	66	21	early	early	JJ
cord-336510-qzm9wgde	66	22	(	(	-LRB-
cord-336510-qzm9wgde	66	23	β	β	NN
cord-336510-qzm9wgde	66	24	)	)	-RRB-
cord-336510-qzm9wgde	66	25	,	,	,
cord-336510-qzm9wgde	66	26	early	early	JJ
cord-336510-qzm9wgde	66	27	late	late	RB
cord-336510-qzm9wgde	66	28	(	(	-LRB-
cord-336510-qzm9wgde	66	29	γ	γ	NN
cord-336510-qzm9wgde	66	30	1	1	CD
cord-336510-qzm9wgde	66	31	)	)	-RRB-
cord-336510-qzm9wgde	66	32	and	and	CC
cord-336510-qzm9wgde	66	33	late	late	JJ
cord-336510-qzm9wgde	66	34	(	(	-LRB-
cord-336510-qzm9wgde	66	35	γ	γ	NN
cord-336510-qzm9wgde	66	36	2	2	CD
cord-336510-qzm9wgde	66	37	)	)	-RRB-
cord-336510-qzm9wgde	66	38	genes	gene	NNS
cord-336510-qzm9wgde	66	39	,	,	,
cord-336510-qzm9wgde	66	40	each	each	DT
cord-336510-qzm9wgde	66	41	with	with	IN
cord-336510-qzm9wgde	66	42	a	a	DT
cord-336510-qzm9wgde	66	43	certain	certain	JJ
cord-336510-qzm9wgde	66	44	characteristic	characteristic	JJ
cord-336510-qzm9wgde	66	45	group	group	NN
cord-336510-qzm9wgde	66	46	of	of	IN
cord-336510-qzm9wgde	66	47	promoters	promoter	NNS
cord-336510-qzm9wgde	66	48	regulating	regulate	VBG
cord-336510-qzm9wgde	66	49	the	the	DT
cord-336510-qzm9wgde	66	50	sequential	sequential	JJ
cord-336510-qzm9wgde	66	51	expression	expression	NN
cord-336510-qzm9wgde	66	52	[	[	-LRB-
cord-336510-qzm9wgde	66	53	29	29	CD
cord-336510-qzm9wgde	66	54	,	,	,
cord-336510-qzm9wgde	66	55	32	32	CD
cord-336510-qzm9wgde	66	56	]	]	-RRB-
cord-336510-qzm9wgde	66	57	.	.	.
cord-336510-qzm9wgde	67	1	Generally	generally	RB
cord-336510-qzm9wgde	67	2	,	,	,
cord-336510-qzm9wgde	67	3	the	the	DT
cord-336510-qzm9wgde	67	4	α	α	NN
cord-336510-qzm9wgde	67	5	-	-	HYPH
cord-336510-qzm9wgde	67	6	gene	gene	NN
cord-336510-qzm9wgde	67	7	products	product	NNS
cord-336510-qzm9wgde	67	8	are	be	VBP
cord-336510-qzm9wgde	67	9	transcription	transcription	NN
cord-336510-qzm9wgde	67	10	inducers	inducer	NNS
cord-336510-qzm9wgde	67	11	,	,	,
cord-336510-qzm9wgde	67	12	the	the	DT
cord-336510-qzm9wgde	67	13	β	β	NN
cord-336510-qzm9wgde	67	14	-	-	HYPH
cord-336510-qzm9wgde	67	15	gene	gene	NN
cord-336510-qzm9wgde	67	16	products	product	NNS
cord-336510-qzm9wgde	67	17	are	be	VBP
cord-336510-qzm9wgde	67	18	viral	viral	JJ
cord-336510-qzm9wgde	67	19	enzymes	enzyme	NNS
cord-336510-qzm9wgde	67	20	such	such	JJ
cord-336510-qzm9wgde	67	21	as	as	IN
cord-336510-qzm9wgde	67	22	the	the	DT
cord-336510-qzm9wgde	67	23	thymidine	thymidine	NN
cord-336510-qzm9wgde	67	24	kinase	kinase	NN
cord-336510-qzm9wgde	67	25	and	and	CC
cord-336510-qzm9wgde	67	26	the	the	DT
cord-336510-qzm9wgde	67	27	viral	viral	JJ
cord-336510-qzm9wgde	67	28	DNA	dna	NN
cord-336510-qzm9wgde	67	29	polymerase	polymerase	NN
cord-336510-qzm9wgde	67	30	,	,	,
cord-336510-qzm9wgde	67	31	and	and	CC
cord-336510-qzm9wgde	67	32	the	the	DT
cord-336510-qzm9wgde	67	33	products	product	NNS
cord-336510-qzm9wgde	67	34	of	of	IN
cord-336510-qzm9wgde	67	35	γgenes	γgene	NNS
cord-336510-qzm9wgde	67	36	are	be	VBP
cord-336510-qzm9wgde	67	37	the	the	DT
cord-336510-qzm9wgde	67	38	structural	structural	JJ
cord-336510-qzm9wgde	67	39	proteins	protein	NNS
cord-336510-qzm9wgde	67	40	of	of	IN
cord-336510-qzm9wgde	67	41	the	the	DT
cord-336510-qzm9wgde	67	42	viral	viral	JJ
cord-336510-qzm9wgde	67	43	particle	particle	NN
cord-336510-qzm9wgde	67	44	[	[	-LRB-
cord-336510-qzm9wgde	67	45	33	33	CD
cord-336510-qzm9wgde	67	46	]	]	-RRB-
cord-336510-qzm9wgde	67	47	.	.	.
cord-336510-qzm9wgde	68	1	The	the	DT
cord-336510-qzm9wgde	68	2	viral	viral	JJ
cord-336510-qzm9wgde	68	3	transcriptional	transcriptional	JJ
cord-336510-qzm9wgde	68	4	chain	chain	NN
cord-336510-qzm9wgde	68	5	is	be	VBZ
cord-336510-qzm9wgde	68	6	closed	close	VBN
cord-336510-qzm9wgde	68	7	by	by	IN
cord-336510-qzm9wgde	68	8	some	some	DT
cord-336510-qzm9wgde	68	9	of	of	IN
cord-336510-qzm9wgde	68	10	the	the	DT
cord-336510-qzm9wgde	68	11	tegument	tegument	NN
cord-336510-qzm9wgde	68	12	proteins	protein	NNS
cord-336510-qzm9wgde	68	13	(	(	-LRB-
cord-336510-qzm9wgde	68	14	e.g.	e.g.	RB
cord-336510-qzm9wgde	68	15	VP16	VP16	NNP
cord-336510-qzm9wgde	68	16	/	/	SYM
cord-336510-qzm9wgde	68	17	Vmw65	Vmw65	NNP
cord-336510-qzm9wgde	68	18	)	)	-RRB-
cord-336510-qzm9wgde	68	19	which	which	WDT
cord-336510-qzm9wgde	68	20	are	be	VBP
cord-336510-qzm9wgde	68	21	γ	γ	NN
cord-336510-qzm9wgde	68	22	-	-	HYPH
cord-336510-qzm9wgde	68	23	gene	gene	NN
cord-336510-qzm9wgde	68	24	products	product	NNS
cord-336510-qzm9wgde	68	25	with	with	IN
cord-336510-qzm9wgde	68	26	structural	structural	JJ
cord-336510-qzm9wgde	68	27	properties	property	NNS
cord-336510-qzm9wgde	68	28	in	in	IN
cord-336510-qzm9wgde	68	29	the	the	DT
cord-336510-qzm9wgde	68	30	tegument	tegument	NN
cord-336510-qzm9wgde	68	31	of	of	IN
cord-336510-qzm9wgde	68	32	the	the	DT
cord-336510-qzm9wgde	68	33	viral	viral	JJ
cord-336510-qzm9wgde	68	34	particle	particle	NN
cord-336510-qzm9wgde	68	35	and	and	CC
cord-336510-qzm9wgde	68	36	besides	besides	IN
cord-336510-qzm9wgde	68	37	this	this	DT
cord-336510-qzm9wgde	68	38	harbour	harbour	NN
cord-336510-qzm9wgde	68	39	transcriptioninducing	transcriptioninducing	NN
cord-336510-qzm9wgde	68	40	capacity	capacity	NN
cord-336510-qzm9wgde	68	41	upon	upon	IN
cord-336510-qzm9wgde	68	42	α	α	NN
cord-336510-qzm9wgde	68	43	-	-	HYPH
cord-336510-qzm9wgde	68	44	gene	gene	NN
cord-336510-qzm9wgde	68	45	promoters	promoter	NNS
cord-336510-qzm9wgde	68	46	crucial	crucial	JJ
cord-336510-qzm9wgde	68	47	in	in	IN
cord-336510-qzm9wgde	68	48	the	the	DT
cord-336510-qzm9wgde	68	49	induction	induction	NN
cord-336510-qzm9wgde	68	50	of	of	IN
cord-336510-qzm9wgde	68	51	the	the	DT
cord-336510-qzm9wgde	68	52	next	next	JJ
cord-336510-qzm9wgde	68	53	replication	replication	NN
cord-336510-qzm9wgde	68	54	cycle	cycle	NN
cord-336510-qzm9wgde	68	55	of	of	IN
cord-336510-qzm9wgde	68	56	the	the	DT
cord-336510-qzm9wgde	68	57	virus	virus	NN
cord-336510-qzm9wgde	68	58	[	[	-LRB-
cord-336510-qzm9wgde	68	59	32	32	CD
cord-336510-qzm9wgde	68	60	,	,	,
cord-336510-qzm9wgde	68	61	34	34	CD
cord-336510-qzm9wgde	68	62	]	]	-RRB-
cord-336510-qzm9wgde	68	63	.	.	.
cord-336510-qzm9wgde	69	1	The	the	DT
cord-336510-qzm9wgde	69	2	HSV	HSV	NNP
cord-336510-qzm9wgde	69	3	infection	infection	NN
cord-336510-qzm9wgde	69	4	is	be	VBZ
cord-336510-qzm9wgde	69	5	initiated	initiate	VBN
cord-336510-qzm9wgde	69	6	by	by	IN
cord-336510-qzm9wgde	69	7	adsorption	adsorption	NN
cord-336510-qzm9wgde	69	8	of	of	IN
cord-336510-qzm9wgde	69	9	the	the	DT
cord-336510-qzm9wgde	69	10	viral	viral	JJ
cord-336510-qzm9wgde	69	11	particle	particle	NN
cord-336510-qzm9wgde	69	12	via	via	IN
cord-336510-qzm9wgde	69	13	gB	gB	NNP
cord-336510-qzm9wgde	69	14	or	or	CC
cord-336510-qzm9wgde	69	15	gC	gc	NN
cord-336510-qzm9wgde	69	16	to	to	IN
cord-336510-qzm9wgde	69	17	a	a	DT
cord-336510-qzm9wgde	69	18	cellular	cellular	JJ
cord-336510-qzm9wgde	69	19	receptor	receptor	NN
cord-336510-qzm9wgde	69	20	,	,	,
cord-336510-qzm9wgde	69	21	which	which	WDT
cord-336510-qzm9wgde	69	22	is	be	VBZ
cord-336510-qzm9wgde	69	23	a	a	DT
cord-336510-qzm9wgde	69	24	heparan	heparan	JJ
cord-336510-qzm9wgde	69	25	sulphate	sulphate	NN
cord-336510-qzm9wgde	69	26	chain	chain	NN
cord-336510-qzm9wgde	69	27	on	on	IN
cord-336510-qzm9wgde	69	28	cellular	cellular	JJ
cord-336510-qzm9wgde	69	29	proteoglycans	proteoglycan	NNS
cord-336510-qzm9wgde	69	30	[	[	-LRB-
cord-336510-qzm9wgde	69	31	35	35	CD
cord-336510-qzm9wgde	69	32	]	]	-RRB-
cord-336510-qzm9wgde	69	33	.	.	.
cord-336510-qzm9wgde	70	1	Thus	thus	RB
cord-336510-qzm9wgde	70	2	HSV	HSV	NNP
cord-336510-qzm9wgde	70	3	adsorption	adsorption	NN
cord-336510-qzm9wgde	70	4	can	can	MD
cord-336510-qzm9wgde	70	5	be	be	VB
cord-336510-qzm9wgde	70	6	inhibited	inhibit	VBN
cord-336510-qzm9wgde	70	7	by	by	IN
cord-336510-qzm9wgde	70	8	heparin	heparin	NN
cord-336510-qzm9wgde	70	9	and	and	CC
cord-336510-qzm9wgde	70	10	soluble	soluble	JJ
cord-336510-qzm9wgde	70	11	heparan	heparan	JJ
cord-336510-qzm9wgde	70	12	sulfates	sulfate	NNS
cord-336510-qzm9wgde	70	13	[	[	-LRB-
cord-336510-qzm9wgde	70	14	36	36	CD
cord-336510-qzm9wgde	70	15	,	,	,
cord-336510-qzm9wgde	70	16	37	37	CD
cord-336510-qzm9wgde	70	17	]	]	-RRB-
cord-336510-qzm9wgde	70	18	.	.	.
cord-336510-qzm9wgde	71	1	This	this	DT
cord-336510-qzm9wgde	71	2	initial	initial	JJ
cord-336510-qzm9wgde	71	3	binding	binding	NN
cord-336510-qzm9wgde	71	4	,	,	,
cord-336510-qzm9wgde	71	5	in	in	IN
cord-336510-qzm9wgde	71	6	which	which	WDT
cord-336510-qzm9wgde	71	7	gC	gc	NN
cord-336510-qzm9wgde	71	8	is	be	VBZ
cord-336510-qzm9wgde	71	9	important	important	JJ
cord-336510-qzm9wgde	71	10	but	but	CC
cord-336510-qzm9wgde	71	11	dispensable	dispensable	JJ
cord-336510-qzm9wgde	71	12	,	,	,
cord-336510-qzm9wgde	71	13	is	be	VBZ
cord-336510-qzm9wgde	71	14	of	of	IN
cord-336510-qzm9wgde	71	15	greater	great	JJR
cord-336510-qzm9wgde	71	16	significance	significance	NN
cord-336510-qzm9wgde	71	17	for	for	IN
cord-336510-qzm9wgde	71	18	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	71	19	than	than	IN
cord-336510-qzm9wgde	71	20	for	for	IN
cord-336510-qzm9wgde	71	21	HSV-2	HSV-2	NNP
cord-336510-qzm9wgde	71	22	,	,	,
cord-336510-qzm9wgde	71	23	a	a	DT
cord-336510-qzm9wgde	71	24	divergence	divergence	NN
cord-336510-qzm9wgde	71	25	which	which	WDT
cord-336510-qzm9wgde	71	26	could	could	MD
cord-336510-qzm9wgde	71	27	have	have	VB
cord-336510-qzm9wgde	71	28	implications	implication	NNS
cord-336510-qzm9wgde	71	29	for	for	IN
cord-336510-qzm9wgde	71	30	the	the	DT
cord-336510-qzm9wgde	71	31	different	different	JJ
cord-336510-qzm9wgde	71	32	pathogenic	pathogenic	JJ
cord-336510-qzm9wgde	71	33	patterns	pattern	NNS
cord-336510-qzm9wgde	71	34	of	of	IN
cord-336510-qzm9wgde	71	35	the	the	DT
cord-336510-qzm9wgde	71	36	two	two	CD
cord-336510-qzm9wgde	71	37	strains	strain	NNS
cord-336510-qzm9wgde	71	38	[	[	-LRB-
cord-336510-qzm9wgde	71	39	38	38	CD
cord-336510-qzm9wgde	71	40	,	,	,
cord-336510-qzm9wgde	71	41	39	39	CD
cord-336510-qzm9wgde	71	42	]	]	-RRB-
cord-336510-qzm9wgde	71	43	.	.	.
cord-336510-qzm9wgde	72	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	72	2	,	,	,
cord-336510-qzm9wgde	72	3	trapping	trap	VBG
cord-336510-qzm9wgde	72	4	of	of	IN
cord-336510-qzm9wgde	72	5	HSV	HSV	NNP
cord-336510-qzm9wgde	72	6	to	to	IN
cord-336510-qzm9wgde	72	7	heparan	heparan	JJ
cord-336510-qzm9wgde	72	8	sulfate	sulfate	NN
cord-336510-qzm9wgde	72	9	motives	motive	NNS
cord-336510-qzm9wgde	72	10	in	in	IN
cord-336510-qzm9wgde	72	11	the	the	DT
cord-336510-qzm9wgde	72	12	tissues	tissue	NNS
cord-336510-qzm9wgde	72	13	,	,	,
cord-336510-qzm9wgde	72	14	e.g.	e.g.	RB
cord-336510-qzm9wgde	72	15	basal	basal	NN
cord-336510-qzm9wgde	72	16	laminas	lamina	NNS
cord-336510-qzm9wgde	72	17	,	,	,
cord-336510-qzm9wgde	72	18	may	may	MD
cord-336510-qzm9wgde	72	19	be	be	VB
cord-336510-qzm9wgde	72	20	of	of	IN
cord-336510-qzm9wgde	72	21	importance	importance	NN
cord-336510-qzm9wgde	72	22	for	for	IN
cord-336510-qzm9wgde	72	23	containment	containment	NN
cord-336510-qzm9wgde	72	24	of	of	IN
cord-336510-qzm9wgde	72	25	the	the	DT
cord-336510-qzm9wgde	72	26	infection	infection	NN
cord-336510-qzm9wgde	72	27	at	at	IN
cord-336510-qzm9wgde	72	28	a	a	DT
cord-336510-qzm9wgde	72	29	specific	specific	JJ
cord-336510-qzm9wgde	72	30	site	site	NN
cord-336510-qzm9wgde	72	31	[	[	-LRB-
cord-336510-qzm9wgde	72	32	40	40	CD
cord-336510-qzm9wgde	72	33	]	]	-RRB-
cord-336510-qzm9wgde	72	34	.	.	.
cord-336510-qzm9wgde	73	1	Binding	bind	VBG
cord-336510-qzm9wgde	73	2	to	to	IN
cord-336510-qzm9wgde	73	3	the	the	DT
cord-336510-qzm9wgde	73	4	heparan	heparan	JJ
cord-336510-qzm9wgde	73	5	sulfate	sulfate	NN
cord-336510-qzm9wgde	73	6	-	-	HYPH
cord-336510-qzm9wgde	73	7	containing	contain	VBG
cord-336510-qzm9wgde	73	8	cellular	cellular	JJ
cord-336510-qzm9wgde	73	9	receptors	receptor	NNS
cord-336510-qzm9wgde	73	10	,	,	,
cord-336510-qzm9wgde	73	11	which	which	WDT
cord-336510-qzm9wgde	73	12	are	be	VBP
cord-336510-qzm9wgde	73	13	in	in	IN
cord-336510-qzm9wgde	73	14	size	size	NN
cord-336510-qzm9wgde	73	15	with	with	IN
cord-336510-qzm9wgde	73	16	the	the	DT
cord-336510-qzm9wgde	73	17	HSV	HSV	NNP
cord-336510-qzm9wgde	73	18	particle	particle	NN
cord-336510-qzm9wgde	73	19	itself	-PRON-	PRP
cord-336510-qzm9wgde	73	20	,	,	,
cord-336510-qzm9wgde	73	21	is	be	VBZ
cord-336510-qzm9wgde	73	22	reversible	reversible	JJ
cord-336510-qzm9wgde	73	23	,	,	,
cord-336510-qzm9wgde	73	24	and	and	CC
cord-336510-qzm9wgde	73	25	serves	serve	VBZ
cord-336510-qzm9wgde	73	26	to	to	TO
cord-336510-qzm9wgde	73	27	concentrate	concentrate	VB
cord-336510-qzm9wgde	73	28	the	the	DT
cord-336510-qzm9wgde	73	29	viral	viral	JJ
cord-336510-qzm9wgde	73	30	particle	particle	NN
cord-336510-qzm9wgde	73	31	in	in	IN
cord-336510-qzm9wgde	73	32	near	near	JJ
cord-336510-qzm9wgde	73	33	proximity	proximity	NN
cord-336510-qzm9wgde	73	34	to	to	IN
cord-336510-qzm9wgde	73	35	the	the	DT
cord-336510-qzm9wgde	73	36	cell	cell	NN
cord-336510-qzm9wgde	73	37	(	(	-LRB-
cord-336510-qzm9wgde	73	38	fig	fig	NN
cord-336510-qzm9wgde	73	39	.	.	.
cord-336510-qzm9wgde	73	40	1	1	CD
cord-336510-qzm9wgde	73	41	)	)	-RRB-
cord-336510-qzm9wgde	74	1	[	[	-LRB-
cord-336510-qzm9wgde	74	2	35	35	CD
cord-336510-qzm9wgde	74	3	,	,	,
cord-336510-qzm9wgde	74	4	39	39	CD
cord-336510-qzm9wgde	74	5	,	,	,
cord-336510-qzm9wgde	74	6	41	41	CD
cord-336510-qzm9wgde	74	7	]	]	-RRB-
cord-336510-qzm9wgde	74	8	.	.	.
cord-336510-qzm9wgde	75	1	A	a	DT
cord-336510-qzm9wgde	75	2	crucial	crucial	JJ
cord-336510-qzm9wgde	75	3	step	step	NN
cord-336510-qzm9wgde	75	4	is	be	VBZ
cord-336510-qzm9wgde	75	5	then	then	RB
cord-336510-qzm9wgde	75	6	conducted	conduct	VBN
cord-336510-qzm9wgde	75	7	by	by	IN
cord-336510-qzm9wgde	75	8	gD	gd	DT
cord-336510-qzm9wgde	75	9	binding	bind	VBG
cord-336510-qzm9wgde	75	10	to	to	IN
cord-336510-qzm9wgde	75	11	an	an	DT
cord-336510-qzm9wgde	75	12	entry	entry	NN
cord-336510-qzm9wgde	75	13	receptor	receptor	NN
cord-336510-qzm9wgde	75	14	,	,	,
cord-336510-qzm9wgde	75	15	of	of	IN
cord-336510-qzm9wgde	75	16	which	which	WDT
cord-336510-qzm9wgde	75	17	three	three	CD
cord-336510-qzm9wgde	75	18	classes	class	NNS
cord-336510-qzm9wgde	75	19	has	have	VBZ
cord-336510-qzm9wgde	75	20	been	be	VBN
cord-336510-qzm9wgde	75	21	described	describe	VBN
cord-336510-qzm9wgde	75	22	[	[	-LRB-
cord-336510-qzm9wgde	75	23	42	42	CD
cord-336510-qzm9wgde	75	24	]	]	-RRB-
cord-336510-qzm9wgde	75	25	.	.	.
cord-336510-qzm9wgde	76	1	These	these	DT
cord-336510-qzm9wgde	76	2	include	include	VBP
cord-336510-qzm9wgde	76	3	herpes	herpes	NN
cord-336510-qzm9wgde	76	4	virus	virus	NN
cord-336510-qzm9wgde	76	5	entry	entry	NN
cord-336510-qzm9wgde	76	6	mediator	mediator	NN
cord-336510-qzm9wgde	76	7	(	(	-LRB-
cord-336510-qzm9wgde	76	8	HVEM	HVEM	NNP
cord-336510-qzm9wgde	76	9	)	)	-RRB-
cord-336510-qzm9wgde	76	10	,	,	,
cord-336510-qzm9wgde	76	11	later	later	RB
cord-336510-qzm9wgde	76	12	designated	designate	VBN
cord-336510-qzm9wgde	76	13	as	as	IN
cord-336510-qzm9wgde	76	14	herpes	herpes	NNP
cord-336510-qzm9wgde	76	15	virus	virus	NN
cord-336510-qzm9wgde	76	16	entry	entry	NN
cord-336510-qzm9wgde	76	17	protein	protein	NN
cord-336510-qzm9wgde	76	18	A	A	NNP
cord-336510-qzm9wgde	76	19	(	(	-LRB-
cord-336510-qzm9wgde	76	20	HveA	HveA	NNP
cord-336510-qzm9wgde	76	21	)	)	-RRB-
cord-336510-qzm9wgde	76	22	,	,	,
cord-336510-qzm9wgde	76	23	which	which	WDT
cord-336510-qzm9wgde	76	24	is	be	VBZ
cord-336510-qzm9wgde	76	25	a	a	DT
cord-336510-qzm9wgde	76	26	member	member	NN
cord-336510-qzm9wgde	76	27	of	of	IN
cord-336510-qzm9wgde	76	28	the	the	DT
cord-336510-qzm9wgde	76	29	tumour	tumour	NN
cord-336510-qzm9wgde	76	30	necrosis	necrosis	NN
cord-336510-qzm9wgde	76	31	factor	factor	NN
cord-336510-qzm9wgde	76	32	receptor	receptor	NN
cord-336510-qzm9wgde	76	33	family	family	NN
cord-336510-qzm9wgde	76	34	,	,	,
cord-336510-qzm9wgde	76	35	nectin-1	nectin-1	NNP
cord-336510-qzm9wgde	76	36	(	(	-LRB-
cord-336510-qzm9wgde	76	37	HveC	HveC	NNP
cord-336510-qzm9wgde	76	38	)	)	-RRB-
cord-336510-qzm9wgde	76	39	and	and	CC
cord-336510-qzm9wgde	76	40	nectin-2	nectin-2	NNP
cord-336510-qzm9wgde	76	41	(	(	-LRB-
cord-336510-qzm9wgde	76	42	HveB	HveB	NNP
cord-336510-qzm9wgde	76	43	)	)	-RRB-
cord-336510-qzm9wgde	76	44	,	,	,
cord-336510-qzm9wgde	76	45	both	both	DT
cord-336510-qzm9wgde	76	46	members	member	NNS
cord-336510-qzm9wgde	76	47	of	of	IN
cord-336510-qzm9wgde	76	48	the	the	DT
cord-336510-qzm9wgde	76	49	immunoglobulin	immunoglobulin	NN
cord-336510-qzm9wgde	76	50	superfamily	superfamily	NN
cord-336510-qzm9wgde	76	51	,	,	,
cord-336510-qzm9wgde	76	52	and	and	CC
cord-336510-qzm9wgde	76	53	heparan	heparan	NN
cord-336510-qzm9wgde	76	54	sulfate	sulfate	NN
cord-336510-qzm9wgde	76	55	sites	site	NNS
cord-336510-qzm9wgde	76	56	modified	modify	VBN
cord-336510-qzm9wgde	76	57	by	by	IN
cord-336510-qzm9wgde	76	58	3-O	3-o	CD
cord-336510-qzm9wgde	76	59	-	-	HYPH
cord-336510-qzm9wgde	76	60	sulfotransferases	sulfotransferase	NNS
cord-336510-qzm9wgde	76	61	[	[	-LRB-
cord-336510-qzm9wgde	76	62	43	43	CD
cord-336510-qzm9wgde	76	63	]	]	-RRB-
cord-336510-qzm9wgde	76	64	[	[	-LRB-
cord-336510-qzm9wgde	76	65	44	44	CD
cord-336510-qzm9wgde	76	66	]	]	-RRB-
cord-336510-qzm9wgde	76	67	[	[	-LRB-
cord-336510-qzm9wgde	76	68	45	45	CD
cord-336510-qzm9wgde	76	69	]	]	-RRB-
cord-336510-qzm9wgde	76	70	[	[	-LRB-
cord-336510-qzm9wgde	76	71	46	46	CD
cord-336510-qzm9wgde	76	72	]	]	-RRB-
cord-336510-qzm9wgde	76	73	.	.	.
cord-336510-qzm9wgde	77	1	The	the	DT
cord-336510-qzm9wgde	77	2	differential	differential	JJ
cord-336510-qzm9wgde	77	3	use	use	NN
cord-336510-qzm9wgde	77	4	of	of	IN
cord-336510-qzm9wgde	77	5	these	these	DT
cord-336510-qzm9wgde	77	6	receptors	receptor	NNS
cord-336510-qzm9wgde	77	7	is	be	VBZ
cord-336510-qzm9wgde	77	8	of	of	IN
cord-336510-qzm9wgde	77	9	importance	importance	NN
cord-336510-qzm9wgde	77	10	for	for	IN
cord-336510-qzm9wgde	77	11	HSV	HSV	NNP
cord-336510-qzm9wgde	77	12	entry	entry	NN
cord-336510-qzm9wgde	77	13	of	of	IN
cord-336510-qzm9wgde	77	14	different	different	JJ
cord-336510-qzm9wgde	77	15	cell	cell	NN
cord-336510-qzm9wgde	77	16	types	type	NNS
cord-336510-qzm9wgde	77	17	and	and	CC
cord-336510-qzm9wgde	77	18	infection	infection	NN
cord-336510-qzm9wgde	77	19	of	of	IN
cord-336510-qzm9wgde	77	20	polarized	polarized	JJ
cord-336510-qzm9wgde	77	21	cells	cell	NNS
cord-336510-qzm9wgde	77	22	[	[	-LRB-
cord-336510-qzm9wgde	77	23	47	47	CD
cord-336510-qzm9wgde	77	24	]	]	-RRB-
cord-336510-qzm9wgde	77	25	[	[	-LRB-
cord-336510-qzm9wgde	77	26	48	48	CD
cord-336510-qzm9wgde	77	27	]	]	-RRB-
cord-336510-qzm9wgde	77	28	[	[	-LRB-
cord-336510-qzm9wgde	77	29	49	49	CD
cord-336510-qzm9wgde	77	30	]	]	-RRB-
cord-336510-qzm9wgde	77	31	[	[	-LRB-
cord-336510-qzm9wgde	77	32	50	50	CD
cord-336510-qzm9wgde	77	33	]	]	-RRB-
cord-336510-qzm9wgde	77	34	[	[	-LRB-
cord-336510-qzm9wgde	77	35	51	51	CD
cord-336510-qzm9wgde	77	36	]	]	-RRB-
cord-336510-qzm9wgde	77	37	,	,	,
cord-336510-qzm9wgde	77	38	exemplified	exemplify	VBN
cord-336510-qzm9wgde	77	39	by	by	IN
cord-336510-qzm9wgde	77	40	nectin-1	nectin-1	NNP
cord-336510-qzm9wgde	77	41	,	,	,
cord-336510-qzm9wgde	77	42	which	which	WDT
cord-336510-qzm9wgde	77	43	is	be	VBZ
cord-336510-qzm9wgde	77	44	of	of	IN
cord-336510-qzm9wgde	77	45	importance	importance	NN
cord-336510-qzm9wgde	77	46	in	in	IN
cord-336510-qzm9wgde	77	47	infection	infection	NN
cord-336510-qzm9wgde	77	48	of	of	IN
cord-336510-qzm9wgde	77	49	the	the	DT
cord-336510-qzm9wgde	77	50	vaginal	vaginal	JJ
cord-336510-qzm9wgde	77	51	mucosa	mucosa	NN
cord-336510-qzm9wgde	77	52	[	[	-LRB-
cord-336510-qzm9wgde	77	53	52	52	CD
cord-336510-qzm9wgde	77	54	]	]	-RRB-
cord-336510-qzm9wgde	77	55	.	.	.
cord-336510-qzm9wgde	78	1	Upon	upon	IN
cord-336510-qzm9wgde	78	2	binding	bind	VBG
cord-336510-qzm9wgde	78	3	to	to	IN
cord-336510-qzm9wgde	78	4	one	one	CD
cord-336510-qzm9wgde	78	5	of	of	IN
cord-336510-qzm9wgde	78	6	these	these	DT
cord-336510-qzm9wgde	78	7	entry	entry	NN
cord-336510-qzm9wgde	78	8	receptors	receptor	NNS
cord-336510-qzm9wgde	78	9	,	,	,
cord-336510-qzm9wgde	78	10	conformational	conformational	JJ
cord-336510-qzm9wgde	78	11	changes	change	NNS
cord-336510-qzm9wgde	78	12	in	in	IN
cord-336510-qzm9wgde	78	13	gD	gd	DT
cord-336510-qzm9wgde	78	14	lead	lead	NN
cord-336510-qzm9wgde	78	15	to	to	IN
cord-336510-qzm9wgde	78	16	interaction	interaction	NN
cord-336510-qzm9wgde	78	17	with	with	IN
cord-336510-qzm9wgde	78	18	gB	gB	NNP
cord-336510-qzm9wgde	78	19	or	or	CC
cord-336510-qzm9wgde	78	20	gH	gh	NN
cord-336510-qzm9wgde	78	21	-	-	HYPH
cord-336510-qzm9wgde	78	22	gL	gl	NN
cord-336510-qzm9wgde	78	23	dimer	dimer	NN
cord-336510-qzm9wgde	78	24	,	,	,
cord-336510-qzm9wgde	78	25	which	which	WDT
cord-336510-qzm9wgde	78	26	results	result	VBZ
cord-336510-qzm9wgde	78	27	in	in	IN
cord-336510-qzm9wgde	78	28	membrane	membrane	NN
cord-336510-qzm9wgde	78	29	fusion	fusion	NN
cord-336510-qzm9wgde	78	30	by	by	IN
cord-336510-qzm9wgde	78	31	a	a	DT
cord-336510-qzm9wgde	78	32	mechanism	mechanism	NN
cord-336510-qzm9wgde	78	33	not	not	RB
cord-336510-qzm9wgde	78	34	known	know	VBN
cord-336510-qzm9wgde	78	35	in	in	IN
cord-336510-qzm9wgde	78	36	detail	detail	NN
cord-336510-qzm9wgde	78	37	(	(	-LRB-
cord-336510-qzm9wgde	78	38	fig	fig	NN
cord-336510-qzm9wgde	78	39	.	.	.
cord-336510-qzm9wgde	78	40	1	1	LS
cord-336510-qzm9wgde	78	41	)	)	-RRB-
cord-336510-qzm9wgde	78	42	[	[	-LRB-
cord-336510-qzm9wgde	78	43	41	41	CD
cord-336510-qzm9wgde	78	44	,	,	,
cord-336510-qzm9wgde	78	45	53	53	CD
cord-336510-qzm9wgde	78	46	]	]	-RRB-
cord-336510-qzm9wgde	78	47	.	.	.
cord-336510-qzm9wgde	79	1	The	the	DT
cord-336510-qzm9wgde	79	2	membrane	membrane	NN
cord-336510-qzm9wgde	79	3	fusion	fusion	NN
cord-336510-qzm9wgde	79	4	can	can	MD
cord-336510-qzm9wgde	79	5	take	take	VB
cord-336510-qzm9wgde	79	6	place	place	NN
cord-336510-qzm9wgde	79	7	both	both	DT
cord-336510-qzm9wgde	79	8	with	with	IN
cord-336510-qzm9wgde	79	9	the	the	DT
cord-336510-qzm9wgde	79	10	plasma	plasma	NN
cord-336510-qzm9wgde	79	11	membrane	membrane	NN
cord-336510-qzm9wgde	79	12	on	on	IN
cord-336510-qzm9wgde	79	13	the	the	DT
cord-336510-qzm9wgde	79	14	surface	surface	NN
cord-336510-qzm9wgde	79	15	of	of	IN
cord-336510-qzm9wgde	79	16	the	the	DT
cord-336510-qzm9wgde	79	17	target	target	NN
cord-336510-qzm9wgde	79	18	cell	cell	NN
cord-336510-qzm9wgde	79	19	and	and	CC
cord-336510-qzm9wgde	79	20	with	with	IN
cord-336510-qzm9wgde	79	21	an	an	DT
cord-336510-qzm9wgde	79	22	endosomal	endosomal	JJ
cord-336510-qzm9wgde	79	23	membrane	membrane	NN
cord-336510-qzm9wgde	79	24	after	after	IN
cord-336510-qzm9wgde	79	25	intraluminal	intraluminal	JJ
cord-336510-qzm9wgde	79	26	pH	ph	NN
cord-336510-qzm9wgde	79	27	-	-	HYPH
cord-336510-qzm9wgde	79	28	reduction	reduction	NN
cord-336510-qzm9wgde	79	29	,	,	,
cord-336510-qzm9wgde	79	30	as	as	IN
cord-336510-qzm9wgde	79	31	it	-PRON-	PRP
cord-336510-qzm9wgde	79	32	is	be	VBZ
cord-336510-qzm9wgde	79	33	seen	see	VBN
cord-336510-qzm9wgde	79	34	for	for	IN
cord-336510-qzm9wgde	79	35	some	some	DT
cord-336510-qzm9wgde	79	36	other	other	JJ
cord-336510-qzm9wgde	79	37	enveloped	envelop	VBN
cord-336510-qzm9wgde	79	38	viruses	virus	NNS
cord-336510-qzm9wgde	79	39	[	[	-LRB-
cord-336510-qzm9wgde	79	40	50,54	50,54	CD
cord-336510-qzm9wgde	79	41	-	-	SYM
cord-336510-qzm9wgde	79	42	56	56	CD
cord-336510-qzm9wgde	79	43	]	]	-RRB-
cord-336510-qzm9wgde	79	44	.	.	.
cord-336510-qzm9wgde	80	1	Following	follow	VBG
cord-336510-qzm9wgde	80	2	these	these	DT
cord-336510-qzm9wgde	80	3	initial	initial	JJ
cord-336510-qzm9wgde	80	4	steps	step	NNS
cord-336510-qzm9wgde	80	5	of	of	IN
cord-336510-qzm9wgde	80	6	infection	infection	NN
cord-336510-qzm9wgde	80	7	several	several	JJ
cord-336510-qzm9wgde	80	8	immunomodulatory	immunomodulatory	JJ
cord-336510-qzm9wgde	80	9	cellular	cellular	JJ
cord-336510-qzm9wgde	80	10	events	event	NNS
cord-336510-qzm9wgde	80	11	are	be	VBP
cord-336510-qzm9wgde	80	12	induced	induce	VBN
cord-336510-qzm9wgde	80	13	,	,	,
cord-336510-qzm9wgde	80	14	but	but	CC
cord-336510-qzm9wgde	80	15	the	the	DT
cord-336510-qzm9wgde	80	16	potential	potential	JJ
cord-336510-qzm9wgde	80	17	importance	importance	NN
cord-336510-qzm9wgde	80	18	of	of	IN
cord-336510-qzm9wgde	80	19	signalling	signal	VBG
cord-336510-qzm9wgde	80	20	through	through	IN
cord-336510-qzm9wgde	80	21	receptors	receptor	NNS
cord-336510-qzm9wgde	80	22	involved	involve	VBN
cord-336510-qzm9wgde	80	23	in	in	IN
cord-336510-qzm9wgde	80	24	adsorption	adsorption	NN
cord-336510-qzm9wgde	80	25	and	and	CC
cord-336510-qzm9wgde	80	26	membrane	membrane	NN
cord-336510-qzm9wgde	80	27	fusion	fusion	NN
cord-336510-qzm9wgde	80	28	is	be	VBZ
cord-336510-qzm9wgde	80	29	only	only	RB
cord-336510-qzm9wgde	80	30	scarcely	scarcely	RB
cord-336510-qzm9wgde	80	31	analysed	analyse	VBN
cord-336510-qzm9wgde	80	32	[	[	-LRB-
cord-336510-qzm9wgde	80	33	57	57	CD
cord-336510-qzm9wgde	80	34	]	]	-RRB-
cord-336510-qzm9wgde	80	35	.	.	.
cord-336510-qzm9wgde	81	1	The	the	DT
cord-336510-qzm9wgde	81	2	receptor	receptor	NN
cord-336510-qzm9wgde	81	3	molecule	molecule	NN
cord-336510-qzm9wgde	81	4	HVEM	HVEM	NNP
cord-336510-qzm9wgde	81	5	is	be	VBZ
cord-336510-qzm9wgde	81	6	by	by	IN
cord-336510-qzm9wgde	81	7	its	-PRON-	PRP$
cord-336510-qzm9wgde	81	8	normal	normal	JJ
cord-336510-qzm9wgde	81	9	ligand	ligand	NN
cord-336510-qzm9wgde	81	10	capable	capable	JJ
cord-336510-qzm9wgde	81	11	of	of	IN
cord-336510-qzm9wgde	81	12	inducing	induce	VBG
cord-336510-qzm9wgde	81	13	activation	activation	NN
cord-336510-qzm9wgde	81	14	of	of	IN
cord-336510-qzm9wgde	81	15	nuclear	nuclear	JJ
cord-336510-qzm9wgde	81	16	factor	factor	NN
cord-336510-qzm9wgde	81	17	κB	κB	NNP
cord-336510-qzm9wgde	81	18	(	(	-LRB-
cord-336510-qzm9wgde	81	19	NF	nf	NN
cord-336510-qzm9wgde	81	20	-	-	HYPH
cord-336510-qzm9wgde	81	21	κB	κB	NNP
cord-336510-qzm9wgde	81	22	)	)	-RRB-
cord-336510-qzm9wgde	81	23	and	and	CC
cord-336510-qzm9wgde	81	24	activation	activation	NN
cord-336510-qzm9wgde	81	25	of	of	IN
cord-336510-qzm9wgde	81	26	T	T	NNP
cord-336510-qzm9wgde	81	27	cells	cell	NNS
cord-336510-qzm9wgde	81	28	.	.	.
cord-336510-qzm9wgde	82	1	By	by	IN
cord-336510-qzm9wgde	82	2	interaction	interaction	NN
cord-336510-qzm9wgde	82	3	with	with	IN
cord-336510-qzm9wgde	82	4	HSV	HSV	NNP
cord-336510-qzm9wgde	82	5	-	-	HYPH
cord-336510-qzm9wgde	82	6	gD	gd	NN
cord-336510-qzm9wgde	82	7	these	these	DT
cord-336510-qzm9wgde	82	8	receptor	receptor	NN
cord-336510-qzm9wgde	82	9	responses	response	NNS
cord-336510-qzm9wgde	82	10	are	be	VBP
cord-336510-qzm9wgde	82	11	inhibited	inhibit	VBN
cord-336510-qzm9wgde	82	12	.	.	.
cord-336510-qzm9wgde	83	1	Thus	thus	RB
cord-336510-qzm9wgde	83	2	,	,	,
cord-336510-qzm9wgde	83	3	the	the	DT
cord-336510-qzm9wgde	83	4	HSV	HSV	NNP
cord-336510-qzm9wgde	83	5	interaction	interaction	NN
cord-336510-qzm9wgde	83	6	with	with	IN
cord-336510-qzm9wgde	83	7	at	at	RB
cord-336510-qzm9wgde	83	8	least	least	RBS
cord-336510-qzm9wgde	83	9	one	one	CD
cord-336510-qzm9wgde	83	10	of	of	IN
cord-336510-qzm9wgde	83	11	its	-PRON-	PRP$
cord-336510-qzm9wgde	83	12	receptors	receptor	NNS
cord-336510-qzm9wgde	83	13	has	have	VBZ
cord-336510-qzm9wgde	83	14	multiple	multiple	JJ
cord-336510-qzm9wgde	83	15	potentials	potential	NNS
cord-336510-qzm9wgde	83	16	for	for	IN
cord-336510-qzm9wgde	83	17	modulation	modulation	NN
cord-336510-qzm9wgde	83	18	of	of	IN
cord-336510-qzm9wgde	83	19	the	the	DT
cord-336510-qzm9wgde	83	20	host	host	NN
cord-336510-qzm9wgde	83	21	response	response	NN
cord-336510-qzm9wgde	83	22	to	to	IN
cord-336510-qzm9wgde	83	23	the	the	DT
cord-336510-qzm9wgde	83	24	infection	infection	NN
cord-336510-qzm9wgde	83	25	[	[	-LRB-
cord-336510-qzm9wgde	83	26	58	58	CD
cord-336510-qzm9wgde	83	27	,	,	,
cord-336510-qzm9wgde	83	28	59	59	CD
cord-336510-qzm9wgde	83	29	]	]	-RRB-
cord-336510-qzm9wgde	83	30	.	.	.
cord-336510-qzm9wgde	84	1	Upon	upon	IN
cord-336510-qzm9wgde	84	2	fusion	fusion	NN
cord-336510-qzm9wgde	84	3	,	,	,
cord-336510-qzm9wgde	84	4	the	the	DT
cord-336510-qzm9wgde	84	5	HSV	HSV	NNP
cord-336510-qzm9wgde	84	6	nucleocapsid	nucleocapsid	NN
cord-336510-qzm9wgde	84	7	is	be	VBZ
cord-336510-qzm9wgde	84	8	transported	transport	VBN
cord-336510-qzm9wgde	84	9	by	by	IN
cord-336510-qzm9wgde	84	10	microtubules	microtubule	NNS
cord-336510-qzm9wgde	84	11	to	to	IN
cord-336510-qzm9wgde	84	12	a	a	DT
cord-336510-qzm9wgde	84	13	nuclear	nuclear	JJ
cord-336510-qzm9wgde	84	14	membrane	membrane	NN
cord-336510-qzm9wgde	84	15	pore	pore	NN
cord-336510-qzm9wgde	84	16	where	where	WRB
cord-336510-qzm9wgde	84	17	the	the	DT
cord-336510-qzm9wgde	84	18	viral	viral	JJ
cord-336510-qzm9wgde	84	19	DNA	dna	NN
cord-336510-qzm9wgde	84	20	is	be	VBZ
cord-336510-qzm9wgde	84	21	released	release	VBN
cord-336510-qzm9wgde	84	22	into	into	IN
cord-336510-qzm9wgde	84	23	the	the	DT
cord-336510-qzm9wgde	84	24	nucleus	nucleus	NN
cord-336510-qzm9wgde	84	25	[	[	-LRB-
cord-336510-qzm9wgde	84	26	60,61	60,61	CD
cord-336510-qzm9wgde	84	27	]	]	-RRB-
cord-336510-qzm9wgde	84	28	.	.	.
cord-336510-qzm9wgde	85	1	Both	both	DT
cord-336510-qzm9wgde	85	2	viral	viral	JJ
cord-336510-qzm9wgde	85	3	tegument	tegument	NN
cord-336510-qzm9wgde	85	4	products	product	NNS
cord-336510-qzm9wgde	85	5	and	and	CC
cord-336510-qzm9wgde	85	6	cellular	cellular	JJ
cord-336510-qzm9wgde	85	7	kinases	kinase	NNS
cord-336510-qzm9wgde	85	8	are	be	VBP
cord-336510-qzm9wgde	85	9	responsible	responsible	JJ
cord-336510-qzm9wgde	85	10	for	for	IN
cord-336510-qzm9wgde	85	11	the	the	DT
cord-336510-qzm9wgde	85	12	initiation	initiation	NN
cord-336510-qzm9wgde	85	13	of	of	IN
cord-336510-qzm9wgde	85	14	α	α	NN
cord-336510-qzm9wgde	85	15	-	-	HYPH
cord-336510-qzm9wgde	85	16	gene	gene	NN
cord-336510-qzm9wgde	85	17	transcription	transcription	NN
cord-336510-qzm9wgde	85	18	[	[	-LRB-
cord-336510-qzm9wgde	85	19	62	62	CD
cord-336510-qzm9wgde	85	20	]	]	-RRB-
cord-336510-qzm9wgde	85	21	.	.	.
cord-336510-qzm9wgde	86	1	In	in	IN
cord-336510-qzm9wgde	86	2	these	these	DT
cord-336510-qzm9wgde	86	3	initial	initial	JJ
cord-336510-qzm9wgde	86	4	events	event	NNS
cord-336510-qzm9wgde	86	5	the	the	DT
cord-336510-qzm9wgde	86	6	determination	determination	NN
cord-336510-qzm9wgde	86	7	of	of	IN
cord-336510-qzm9wgde	86	8	whether	whether	IN
cord-336510-qzm9wgde	86	9	it	-PRON-	PRP
cord-336510-qzm9wgde	86	10	will	will	MD
cord-336510-qzm9wgde	86	11	lead	lead	VB
cord-336510-qzm9wgde	86	12	to	to	IN
cord-336510-qzm9wgde	86	13	a	a	DT
cord-336510-qzm9wgde	86	14	lytic	lytic	JJ
cord-336510-qzm9wgde	86	15	infection	infection	NN
cord-336510-qzm9wgde	86	16	cycle	cycle	NN
cord-336510-qzm9wgde	86	17	or	or	CC
cord-336510-qzm9wgde	86	18	a	a	DT
cord-336510-qzm9wgde	86	19	latent	latent	JJ
cord-336510-qzm9wgde	86	20	infection	infection	NN
cord-336510-qzm9wgde	86	21	seems	seem	VBZ
cord-336510-qzm9wgde	86	22	to	to	TO
cord-336510-qzm9wgde	86	23	be	be	VB
cord-336510-qzm9wgde	86	24	directed	direct	VBN
cord-336510-qzm9wgde	86	25	largely	largely	RB
cord-336510-qzm9wgde	86	26	by	by	IN
cord-336510-qzm9wgde	86	27	the	the	DT
cord-336510-qzm9wgde	86	28	infected	infected	JJ
cord-336510-qzm9wgde	86	29	cell	cell	NN
cord-336510-qzm9wgde	86	30	type	type	NN
cord-336510-qzm9wgde	86	31	in	in	IN
cord-336510-qzm9wgde	86	32	question	question	NN
cord-336510-qzm9wgde	86	33	[	[	-LRB-
cord-336510-qzm9wgde	86	34	63	63	CD
cord-336510-qzm9wgde	86	35	,	,	,
cord-336510-qzm9wgde	86	36	64	64	CD
cord-336510-qzm9wgde	86	37	]	]	-RRB-
cord-336510-qzm9wgde	86	38	.	.	.
cord-336510-qzm9wgde	87	1	A	a	DT
cord-336510-qzm9wgde	87	2	key	key	JJ
cord-336510-qzm9wgde	87	3	event	event	NN
cord-336510-qzm9wgde	87	4	in	in	IN
cord-336510-qzm9wgde	87	5	this	this	DT
cord-336510-qzm9wgde	87	6	seems	seem	VBZ
cord-336510-qzm9wgde	87	7	to	to	TO
cord-336510-qzm9wgde	87	8	be	be	VB
cord-336510-qzm9wgde	87	9	early	early	JJ
cord-336510-qzm9wgde	87	10	induction	induction	NN
cord-336510-qzm9wgde	87	11	of	of	IN
cord-336510-qzm9wgde	87	12	latency	latency	NN
cord-336510-qzm9wgde	87	13	-	-	HYPH
cord-336510-qzm9wgde	87	14	associated	associate	VBN
cord-336510-qzm9wgde	87	15	transcripts	transcript	NNS
cord-336510-qzm9wgde	87	16	(	(	-LRB-
cord-336510-qzm9wgde	87	17	LATs	LATs	NNP
cord-336510-qzm9wgde	87	18	)	)	-RRB-
cord-336510-qzm9wgde	87	19	with	with	IN
cord-336510-qzm9wgde	87	20	sequences	sequence	NNS
cord-336510-qzm9wgde	87	21	antisense	antisense	NNP
cord-336510-qzm9wgde	87	22	to	to	IN
cord-336510-qzm9wgde	87	23	the	the	DT
cord-336510-qzm9wgde	87	24	infected	infected	JJ
cord-336510-qzm9wgde	87	25	cell	cell	NN
cord-336510-qzm9wgde	87	26	protein	protein	NN
cord-336510-qzm9wgde	87	27	null	null	NN
cord-336510-qzm9wgde	87	28	(	(	-LRB-
cord-336510-qzm9wgde	87	29	ICP0	ICP0	NNP
cord-336510-qzm9wgde	87	30	)	)	-RRB-
cord-336510-qzm9wgde	87	31	and	and	CC
cord-336510-qzm9wgde	87	32	ICP4	ICP4	NNP
cord-336510-qzm9wgde	87	33	[	[	-LRB-
cord-336510-qzm9wgde	87	34	65	65	CD
cord-336510-qzm9wgde	87	35	]	]	-RRB-
cord-336510-qzm9wgde	87	36	[	[	-LRB-
cord-336510-qzm9wgde	87	37	66	66	CD
cord-336510-qzm9wgde	87	38	]	]	-RRB-
cord-336510-qzm9wgde	87	39	[	[	-LRB-
cord-336510-qzm9wgde	87	40	67	67	CD
cord-336510-qzm9wgde	87	41	]	]	-RRB-
cord-336510-qzm9wgde	87	42	.	.	.
cord-336510-qzm9wgde	88	1	In	in	IN
cord-336510-qzm9wgde	88	2	the	the	DT
cord-336510-qzm9wgde	88	3	HSV	HSV	NNP
cord-336510-qzm9wgde	88	4	composition	composition	NN
cord-336510-qzm9wgde	88	5	and	and	CC
cord-336510-qzm9wgde	88	6	entry	entry	NN
cord-336510-qzm9wgde	88	7	Figure	figure	NN
cord-336510-qzm9wgde	88	8	1	1	CD
cord-336510-qzm9wgde	88	9	HSV	HSV	NNP
cord-336510-qzm9wgde	88	10	composition	composition	NN
cord-336510-qzm9wgde	88	11	and	and	CC
cord-336510-qzm9wgde	88	12	entry	entry	NN
cord-336510-qzm9wgde	88	13	.	.	.
cord-336510-qzm9wgde	89	1	Electron	electron	NN
cord-336510-qzm9wgde	89	2	micrograph	micrograph	NN
cord-336510-qzm9wgde	89	3	of	of	IN
cord-336510-qzm9wgde	89	4	negatively	negatively	RB
cord-336510-qzm9wgde	89	5	stained	stain	VBN
cord-336510-qzm9wgde	89	6	HSV	hsv	NN
cord-336510-qzm9wgde	89	7	particle	particle	NN
cord-336510-qzm9wgde	89	8	with	with	IN
cord-336510-qzm9wgde	89	9	indications	indication	NNS
cord-336510-qzm9wgde	89	10	of	of	IN
cord-336510-qzm9wgde	89	11	major	major	JJ
cord-336510-qzm9wgde	89	12	structural	structural	JJ
cord-336510-qzm9wgde	89	13	elements	element	NNS
cord-336510-qzm9wgde	89	14	.	.	.
cord-336510-qzm9wgde	90	1	Important	important	JJ
cord-336510-qzm9wgde	90	2	mediators	mediator	NNS
cord-336510-qzm9wgde	90	3	of	of	IN
cord-336510-qzm9wgde	90	4	adsorption	adsorption	NN
cord-336510-qzm9wgde	90	5	to	to	IN
cord-336510-qzm9wgde	90	6	cells	cell	NNS
cord-336510-qzm9wgde	90	7	(	(	-LRB-
cord-336510-qzm9wgde	90	8	1	1	CD
cord-336510-qzm9wgde	90	9	)	)	-RRB-
cord-336510-qzm9wgde	90	10	,	,	,
cord-336510-qzm9wgde	90	11	receptor	receptor	NN
cord-336510-qzm9wgde	90	12	binding	binding	NN
cord-336510-qzm9wgde	90	13	(	(	-LRB-
cord-336510-qzm9wgde	90	14	2	2	CD
cord-336510-qzm9wgde	90	15	)	)	-RRB-
cord-336510-qzm9wgde	90	16	and	and	CC
cord-336510-qzm9wgde	90	17	fusion	fusion	NN
cord-336510-qzm9wgde	90	18	of	of	IN
cord-336510-qzm9wgde	90	19	membranes	membrane	NNS
cord-336510-qzm9wgde	90	20	(	(	-LRB-
cord-336510-qzm9wgde	90	21	3	3	CD
cord-336510-qzm9wgde	90	22	)	)	-RRB-
cord-336510-qzm9wgde	90	23	during	during	IN
cord-336510-qzm9wgde	90	24	the	the	DT
cord-336510-qzm9wgde	90	25	process	process	NN
cord-336510-qzm9wgde	90	26	of	of	IN
cord-336510-qzm9wgde	90	27	infection	infection	NN
cord-336510-qzm9wgde	90	28	are	be	VBP
cord-336510-qzm9wgde	90	29	drawn	draw	VBN
cord-336510-qzm9wgde	90	30	stylistically	stylistically	RB
cord-336510-qzm9wgde	90	31	.	.	.
cord-336510-qzm9wgde	91	1	initial	initial	JJ
cord-336510-qzm9wgde	91	2	phase	phase	NN
cord-336510-qzm9wgde	91	3	of	of	IN
cord-336510-qzm9wgde	91	4	the	the	DT
cord-336510-qzm9wgde	91	5	lytic	lytic	JJ
cord-336510-qzm9wgde	91	6	replication	replication	NN
cord-336510-qzm9wgde	91	7	cycle	cycle	NN
cord-336510-qzm9wgde	91	8	,	,	,
cord-336510-qzm9wgde	91	9	the	the	DT
cord-336510-qzm9wgde	91	10	IE	ie	NN
cord-336510-qzm9wgde	91	11	-	-	HYPH
cord-336510-qzm9wgde	91	12	gene	gene	NN
cord-336510-qzm9wgde	91	13	products	product	NNS
cord-336510-qzm9wgde	91	14	,	,	,
cord-336510-qzm9wgde	91	15	besides	besides	IN
cord-336510-qzm9wgde	91	16	being	be	VBG
cord-336510-qzm9wgde	91	17	transcription	transcription	NN
cord-336510-qzm9wgde	91	18	factors	factor	NNS
cord-336510-qzm9wgde	91	19	for	for	IN
cord-336510-qzm9wgde	91	20	the	the	DT
cord-336510-qzm9wgde	91	21	next	next	JJ
cord-336510-qzm9wgde	91	22	wave	wave	NN
cord-336510-qzm9wgde	91	23	of	of	IN
cord-336510-qzm9wgde	91	24	viral	viral	JJ
cord-336510-qzm9wgde	91	25	proteins	protein	NNS
cord-336510-qzm9wgde	91	26	,	,	,
cord-336510-qzm9wgde	91	27	intimately	intimately	RB
cord-336510-qzm9wgde	91	28	regulate	regulate	VBP
cord-336510-qzm9wgde	91	29	cellular	cellular	JJ
cord-336510-qzm9wgde	91	30	functions	function	NNS
cord-336510-qzm9wgde	91	31	in	in	IN
cord-336510-qzm9wgde	91	32	favour	favour	NN
cord-336510-qzm9wgde	91	33	of	of	IN
cord-336510-qzm9wgde	91	34	viral	viral	JJ
cord-336510-qzm9wgde	91	35	replication	replication	NN
cord-336510-qzm9wgde	91	36	and	and	CC
cord-336510-qzm9wgde	91	37	immune	immune	JJ
cord-336510-qzm9wgde	91	38	evasion	evasion	NN
cord-336510-qzm9wgde	91	39	[	[	-LRB-
cord-336510-qzm9wgde	91	40	33	33	CD
cord-336510-qzm9wgde	91	41	,	,	,
cord-336510-qzm9wgde	91	42	68	68	CD
cord-336510-qzm9wgde	91	43	]	]	-RRB-
cord-336510-qzm9wgde	91	44	.	.	.
cord-336510-qzm9wgde	92	1	Of	of	IN
cord-336510-qzm9wgde	92	2	these	these	DT
cord-336510-qzm9wgde	92	3	,	,	,
cord-336510-qzm9wgde	92	4	the	the	DT
cord-336510-qzm9wgde	92	5	ICP0	ICP0	NNP
cord-336510-qzm9wgde	92	6	,	,	,
cord-336510-qzm9wgde	92	7	a	a	DT
cord-336510-qzm9wgde	92	8	promiscuous	promiscuous	JJ
cord-336510-qzm9wgde	92	9	transactivator	transactivator	NN
cord-336510-qzm9wgde	92	10	without	without	IN
cord-336510-qzm9wgde	92	11	much	much	JJ
cord-336510-qzm9wgde	92	12	DNA	dna	NN
cord-336510-qzm9wgde	92	13	-	-	HYPH
cord-336510-qzm9wgde	92	14	binding	bind	VBG
cord-336510-qzm9wgde	92	15	capacity	capacity	NN
cord-336510-qzm9wgde	92	16	,	,	,
cord-336510-qzm9wgde	92	17	forces	force	VBZ
cord-336510-qzm9wgde	92	18	the	the	DT
cord-336510-qzm9wgde	92	19	cell	cell	NN
cord-336510-qzm9wgde	92	20	to	to	IN
cord-336510-qzm9wgde	92	21	a	a	DT
cord-336510-qzm9wgde	92	22	pre	pre	JJ
cord-336510-qzm9wgde	92	23	-	-	JJ
cord-336510-qzm9wgde	92	24	dividing	divide	VBG
cord-336510-qzm9wgde	92	25	state	state	NN
cord-336510-qzm9wgde	92	26	optimal	optimal	JJ
cord-336510-qzm9wgde	92	27	for	for	IN
cord-336510-qzm9wgde	92	28	viral	viral	JJ
cord-336510-qzm9wgde	92	29	protein	protein	NN
cord-336510-qzm9wgde	92	30	synthesis	synthesis	NN
cord-336510-qzm9wgde	92	31	[	[	-LRB-
cord-336510-qzm9wgde	92	32	69	69	CD
cord-336510-qzm9wgde	92	33	,	,	,
cord-336510-qzm9wgde	92	34	70	70	CD
cord-336510-qzm9wgde	92	35	]	]	-RRB-
cord-336510-qzm9wgde	92	36	.	.	.
cord-336510-qzm9wgde	93	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	93	2	,	,	,
cord-336510-qzm9wgde	93	3	ICP0	ICP0	NNP
cord-336510-qzm9wgde	93	4	is	be	VBZ
cord-336510-qzm9wgde	93	5	active	active	JJ
cord-336510-qzm9wgde	93	6	in	in	IN
cord-336510-qzm9wgde	93	7	inhibiting	inhibit	VBG
cord-336510-qzm9wgde	93	8	immune	immune	JJ
cord-336510-qzm9wgde	93	9	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	93	10	such	such	JJ
cord-336510-qzm9wgde	93	11	as	as	IN
cord-336510-qzm9wgde	93	12	interferon	interferon	NN
cord-336510-qzm9wgde	93	13	production	production	NN
cord-336510-qzm9wgde	93	14	and	and	CC
cord-336510-qzm9wgde	93	15	antiviral	antiviral	JJ
cord-336510-qzm9wgde	93	16	effects	effect	NNS
cord-336510-qzm9wgde	93	17	of	of	IN
cord-336510-qzm9wgde	93	18	interferons	interferon	NNS
cord-336510-qzm9wgde	93	19	[	[	-LRB-
cord-336510-qzm9wgde	93	20	71	71	CD
cord-336510-qzm9wgde	93	21	-	-	SYM
cord-336510-qzm9wgde	93	22	73	73	CD
cord-336510-qzm9wgde	93	23	]	]	-RRB-
cord-336510-qzm9wgde	93	24	and	and	CC
cord-336510-qzm9wgde	93	25	induces	induce	VBZ
cord-336510-qzm9wgde	93	26	degradation	degradation	NN
cord-336510-qzm9wgde	93	27	of	of	IN
cord-336510-qzm9wgde	93	28	cellular	cellular	JJ
cord-336510-qzm9wgde	93	29	proteins	protein	NNS
cord-336510-qzm9wgde	93	30	,	,	,
cord-336510-qzm9wgde	93	31	involving	involve	VBG
cord-336510-qzm9wgde	93	32	the	the	DT
cord-336510-qzm9wgde	93	33	proteasome	proteasome	NN
cord-336510-qzm9wgde	93	34	[	[	-LRB-
cord-336510-qzm9wgde	93	35	74,75	74,75	CD
cord-336510-qzm9wgde	93	36	]	]	-RRB-
cord-336510-qzm9wgde	93	37	.	.	.
cord-336510-qzm9wgde	94	1	Very	very	RB
cord-336510-qzm9wgde	94	2	early	early	RB
cord-336510-qzm9wgde	94	3	in	in	IN
cord-336510-qzm9wgde	94	4	infection	infection	NN
cord-336510-qzm9wgde	94	5	,	,	,
cord-336510-qzm9wgde	94	6	the	the	DT
cord-336510-qzm9wgde	94	7	first	first	JJ
cord-336510-qzm9wgde	94	8	transcriptional	transcriptional	JJ
cord-336510-qzm9wgde	94	9	activity	activity	NN
cord-336510-qzm9wgde	94	10	is	be	VBZ
cord-336510-qzm9wgde	94	11	seen	see	VBN
cord-336510-qzm9wgde	94	12	just	just	RB
cord-336510-qzm9wgde	94	13	inside	inside	IN
cord-336510-qzm9wgde	94	14	the	the	DT
cord-336510-qzm9wgde	94	15	nuclear	nuclear	JJ
cord-336510-qzm9wgde	94	16	membrane	membrane	NN
cord-336510-qzm9wgde	94	17	at	at	IN
cord-336510-qzm9wgde	94	18	the	the	DT
cord-336510-qzm9wgde	94	19	site	site	NN
cord-336510-qzm9wgde	94	20	were	be	VBD
cord-336510-qzm9wgde	95	1	the	the	DT
cord-336510-qzm9wgde	95	2	viral	viral	JJ
cord-336510-qzm9wgde	95	3	DNA	dna	NN
cord-336510-qzm9wgde	95	4	enters	enter	VBZ
cord-336510-qzm9wgde	95	5	the	the	DT
cord-336510-qzm9wgde	95	6	nucleus	nucleus	NN
cord-336510-qzm9wgde	95	7	[	[	-LRB-
cord-336510-qzm9wgde	95	8	76	76	CD
cord-336510-qzm9wgde	95	9	]	]	-RRB-
cord-336510-qzm9wgde	95	10	.	.	.
cord-336510-qzm9wgde	96	1	The	the	DT
cord-336510-qzm9wgde	96	2	produced	produce	VBN
cord-336510-qzm9wgde	96	3	ICP0	ICP0	NNP
cord-336510-qzm9wgde	96	4	colocalizes	colocalizes	NNP
cord-336510-qzm9wgde	96	5	with	with	IN
cord-336510-qzm9wgde	96	6	the	the	DT
cord-336510-qzm9wgde	96	7	promyelocytic	promyelocytic	JJ
cord-336510-qzm9wgde	96	8	leukaemia	leukaemia	NN
cord-336510-qzm9wgde	96	9	(	(	-LRB-
cord-336510-qzm9wgde	96	10	PML	PML	NNP
cord-336510-qzm9wgde	96	11	)	)	-RRB-
cord-336510-qzm9wgde	96	12	nuclear	nuclear	JJ
cord-336510-qzm9wgde	96	13	bodies	body	NNS
cord-336510-qzm9wgde	96	14	and	and	CC
cord-336510-qzm9wgde	96	15	initiates	initiate	VBZ
cord-336510-qzm9wgde	96	16	degradation	degradation	NN
cord-336510-qzm9wgde	96	17	of	of	IN
cord-336510-qzm9wgde	96	18	these	these	DT
cord-336510-qzm9wgde	96	19	,	,	,
cord-336510-qzm9wgde	96	20	an	an	DT
cord-336510-qzm9wgde	96	21	event	event	NN
cord-336510-qzm9wgde	96	22	which	which	WDT
cord-336510-qzm9wgde	96	23	seems	seem	VBZ
cord-336510-qzm9wgde	96	24	to	to	TO
cord-336510-qzm9wgde	96	25	be	be	VB
cord-336510-qzm9wgde	96	26	important	important	JJ
cord-336510-qzm9wgde	96	27	for	for	IN
cord-336510-qzm9wgde	96	28	productive	productive	JJ
cord-336510-qzm9wgde	96	29	replication	replication	NN
cord-336510-qzm9wgde	96	30	of	of	IN
cord-336510-qzm9wgde	96	31	the	the	DT
cord-336510-qzm9wgde	96	32	virus	virus	NN
cord-336510-qzm9wgde	96	33	[	[	-LRB-
cord-336510-qzm9wgde	96	34	77	77	CD
cord-336510-qzm9wgde	96	35	,	,	,
cord-336510-qzm9wgde	96	36	78	78	CD
cord-336510-qzm9wgde	96	37	]	]	-RRB-
cord-336510-qzm9wgde	96	38	.	.	.
cord-336510-qzm9wgde	97	1	ICP4	ICP4	NNP
cord-336510-qzm9wgde	97	2	binds	bind	VBZ
cord-336510-qzm9wgde	97	3	to	to	IN
cord-336510-qzm9wgde	97	4	parental	parental	JJ
cord-336510-qzm9wgde	97	5	viral	viral	JJ
cord-336510-qzm9wgde	97	6	DNA	dna	NN
cord-336510-qzm9wgde	97	7	which	which	WDT
cord-336510-qzm9wgde	97	8	is	be	VBZ
cord-336510-qzm9wgde	97	9	juxta	juxta	NNP
cord-336510-qzm9wgde	97	10	-	-	HYPH
cord-336510-qzm9wgde	97	11	localized	localize	VBN
cord-336510-qzm9wgde	97	12	to	to	IN
cord-336510-qzm9wgde	97	13	the	the	DT
cord-336510-qzm9wgde	97	14	PML	PML	NNP
cord-336510-qzm9wgde	97	15	bodies	body	NNS
cord-336510-qzm9wgde	97	16	,	,	,
cord-336510-qzm9wgde	97	17	and	and	CC
cord-336510-qzm9wgde	97	18	later	later	RBR
cord-336510-qzm9wgde	97	19	,	,	,
cord-336510-qzm9wgde	97	20	when	when	WRB
cord-336510-qzm9wgde	97	21	the	the	DT
cord-336510-qzm9wgde	97	22	bodies	body	NNS
cord-336510-qzm9wgde	97	23	are	be	VBP
cord-336510-qzm9wgde	97	24	degraded	degrade	VBN
cord-336510-qzm9wgde	97	25	,	,	,
cord-336510-qzm9wgde	97	26	replication	replication	NN
cord-336510-qzm9wgde	97	27	compartments	compartment	NNS
cord-336510-qzm9wgde	97	28	are	be	VBP
cord-336510-qzm9wgde	97	29	formed	form	VBN
cord-336510-qzm9wgde	97	30	,	,	,
cord-336510-qzm9wgde	97	31	in	in	IN
cord-336510-qzm9wgde	97	32	which	which	WDT
cord-336510-qzm9wgde	97	33	also	also	RB
cord-336510-qzm9wgde	97	34	ICP27	icp27	PRP
cord-336510-qzm9wgde	97	35	can	can	MD
cord-336510-qzm9wgde	97	36	be	be	VB
cord-336510-qzm9wgde	97	37	found	find	VBN
cord-336510-qzm9wgde	97	38	[	[	-LRB-
cord-336510-qzm9wgde	97	39	76	76	CD
cord-336510-qzm9wgde	97	40	,	,	,
cord-336510-qzm9wgde	97	41	79	79	CD
cord-336510-qzm9wgde	97	42	,	,	,
cord-336510-qzm9wgde	97	43	80	80	CD
cord-336510-qzm9wgde	97	44	]	]	-RRB-
cord-336510-qzm9wgde	97	45	.	.	.
cord-336510-qzm9wgde	98	1	ICP27	icp27	DT
cord-336510-qzm9wgde	98	2	affects	affect	VBZ
cord-336510-qzm9wgde	98	3	the	the	DT
cord-336510-qzm9wgde	98	4	posttranscriptional	posttranscriptional	JJ
cord-336510-qzm9wgde	98	5	polyadenylation	polyadenylation	NN
cord-336510-qzm9wgde	98	6	and	and	CC
cord-336510-qzm9wgde	98	7	splicing	splicing	NN
cord-336510-qzm9wgde	98	8	of	of	IN
cord-336510-qzm9wgde	98	9	RNA	RNA	NNP
cord-336510-qzm9wgde	98	10	,	,	,
cord-336510-qzm9wgde	98	11	and	and	CC
cord-336510-qzm9wgde	98	12	it	-PRON-	PRP
cord-336510-qzm9wgde	98	13	is	be	VBZ
cord-336510-qzm9wgde	98	14	thus	thus	RB
cord-336510-qzm9wgde	98	15	an	an	DT
cord-336510-qzm9wgde	98	16	element	element	NN
cord-336510-qzm9wgde	98	17	of	of	IN
cord-336510-qzm9wgde	98	18	the	the	DT
cord-336510-qzm9wgde	98	19	delayed	delay	VBN
cord-336510-qzm9wgde	98	20	host	host	NN
cord-336510-qzm9wgde	98	21	protein	protein	NN
cord-336510-qzm9wgde	98	22	shutoff	shutoff	NN
cord-336510-qzm9wgde	98	23	[	[	-LRB-
cord-336510-qzm9wgde	98	24	81	81	CD
cord-336510-qzm9wgde	98	25	]	]	-RRB-
cord-336510-qzm9wgde	98	26	.	.	.
cord-336510-qzm9wgde	99	1	Immune	immune	JJ
cord-336510-qzm9wgde	99	2	evasion	evasion	NN
cord-336510-qzm9wgde	99	3	is	be	VBZ
cord-336510-qzm9wgde	99	4	additionally	additionally	RB
cord-336510-qzm9wgde	99	5	induced	induce	VBN
cord-336510-qzm9wgde	99	6	by	by	IN
cord-336510-qzm9wgde	99	7	the	the	DT
cord-336510-qzm9wgde	99	8	IE	IE	NNP
cord-336510-qzm9wgde	99	9	protein	protein	NN
cord-336510-qzm9wgde	99	10	ICP47	ICP47	NNP
cord-336510-qzm9wgde	99	11	which	which	WDT
cord-336510-qzm9wgde	99	12	binds	bind	VBZ
cord-336510-qzm9wgde	99	13	to	to	IN
cord-336510-qzm9wgde	99	14	transporter	transporter	NN
cord-336510-qzm9wgde	99	15	associated	associate	VBN
cord-336510-qzm9wgde	99	16	with	with	IN
cord-336510-qzm9wgde	99	17	antigen	antigen	NN
cord-336510-qzm9wgde	99	18	processing	processing	NN
cord-336510-qzm9wgde	99	19	,	,	,
cord-336510-qzm9wgde	99	20	TAP1	TAP1	NNP
cord-336510-qzm9wgde	99	21	/	/	SYM
cord-336510-qzm9wgde	99	22	TAP2	TAP2	NNP
cord-336510-qzm9wgde	99	23	and	and	CC
cord-336510-qzm9wgde	99	24	blocks	block	VBZ
cord-336510-qzm9wgde	99	25	the	the	DT
cord-336510-qzm9wgde	99	26	presentation	presentation	NN
cord-336510-qzm9wgde	99	27	of	of	IN
cord-336510-qzm9wgde	99	28	viral	viral	JJ
cord-336510-qzm9wgde	99	29	peptides	peptide	NNS
cord-336510-qzm9wgde	99	30	by	by	IN
cord-336510-qzm9wgde	99	31	the	the	DT
cord-336510-qzm9wgde	99	32	major	major	JJ
cord-336510-qzm9wgde	99	33	histocompatibility	histocompatibility	NN
cord-336510-qzm9wgde	99	34	complex	complex	NN
cord-336510-qzm9wgde	99	35	(	(	-LRB-
cord-336510-qzm9wgde	99	36	MHC)-I	MHC)-I	NNP
cord-336510-qzm9wgde	99	37	[	[	-LRB-
cord-336510-qzm9wgde	99	38	82	82	CD
cord-336510-qzm9wgde	99	39	]	]	-RRB-
cord-336510-qzm9wgde	99	40	.	.	.
cord-336510-qzm9wgde	100	1	The	the	DT
cord-336510-qzm9wgde	100	2	HSV	HSV	NNP
cord-336510-qzm9wgde	100	3	progeny	progeny	NN
cord-336510-qzm9wgde	100	4	is	be	VBZ
cord-336510-qzm9wgde	100	5	formed	form	VBN
cord-336510-qzm9wgde	100	6	in	in	IN
cord-336510-qzm9wgde	100	7	the	the	DT
cord-336510-qzm9wgde	100	8	nucleus	nucleus	NN
cord-336510-qzm9wgde	100	9	of	of	IN
cord-336510-qzm9wgde	100	10	the	the	DT
cord-336510-qzm9wgde	100	11	infected	infected	JJ
cord-336510-qzm9wgde	100	12	cell	cell	NN
cord-336510-qzm9wgde	100	13	,	,	,
cord-336510-qzm9wgde	100	14	where	where	WRB
cord-336510-qzm9wgde	100	15	the	the	DT
cord-336510-qzm9wgde	100	16	viral	viral	JJ
cord-336510-qzm9wgde	100	17	DNA	dna	NN
cord-336510-qzm9wgde	100	18	is	be	VBZ
cord-336510-qzm9wgde	100	19	packed	pack	VBN
cord-336510-qzm9wgde	100	20	into	into	IN
cord-336510-qzm9wgde	100	21	preformed	preformed	JJ
cord-336510-qzm9wgde	100	22	capsids	capsid	NNS
cord-336510-qzm9wgde	100	23	.	.	.
cord-336510-qzm9wgde	101	1	These	these	DT
cord-336510-qzm9wgde	101	2	are	be	VBP
cord-336510-qzm9wgde	101	3	assembled	assemble	VBN
cord-336510-qzm9wgde	101	4	with	with	IN
cord-336510-qzm9wgde	101	5	the	the	DT
cord-336510-qzm9wgde	101	6	tegument	tegument	NN
cord-336510-qzm9wgde	101	7	proteins	protein	NNS
cord-336510-qzm9wgde	101	8	and	and	CC
cord-336510-qzm9wgde	101	9	bud	bud	NN
cord-336510-qzm9wgde	101	10	through	through	IN
cord-336510-qzm9wgde	101	11	the	the	DT
cord-336510-qzm9wgde	101	12	inner	inner	JJ
cord-336510-qzm9wgde	101	13	nuclear	nuclear	JJ
cord-336510-qzm9wgde	101	14	membrane	membrane	NN
cord-336510-qzm9wgde	101	15	to	to	IN
cord-336510-qzm9wgde	101	16	the	the	DT
cord-336510-qzm9wgde	101	17	perinuclear	perinuclear	NNP
cord-336510-qzm9wgde	101	18	space	space	NN
cord-336510-qzm9wgde	101	19	[	[	-LRB-
cord-336510-qzm9wgde	101	20	11	11	CD
cord-336510-qzm9wgde	101	21	]	]	-RRB-
cord-336510-qzm9wgde	101	22	.	.	.
cord-336510-qzm9wgde	102	1	The	the	DT
cord-336510-qzm9wgde	102	2	route	route	NN
cord-336510-qzm9wgde	102	3	of	of	IN
cord-336510-qzm9wgde	102	4	virus	virus	NN
cord-336510-qzm9wgde	102	5	from	from	IN
cord-336510-qzm9wgde	102	6	here	here	RB
cord-336510-qzm9wgde	102	7	to	to	IN
cord-336510-qzm9wgde	102	8	the	the	DT
cord-336510-qzm9wgde	102	9	external	external	JJ
cord-336510-qzm9wgde	102	10	side	side	NN
cord-336510-qzm9wgde	102	11	of	of	IN
cord-336510-qzm9wgde	102	12	the	the	DT
cord-336510-qzm9wgde	102	13	cell	cell	NN
cord-336510-qzm9wgde	102	14	is	be	VBZ
cord-336510-qzm9wgde	102	15	controversial	controversial	JJ
cord-336510-qzm9wgde	102	16	.	.	.
cord-336510-qzm9wgde	103	1	Apparently	apparently	RB
cord-336510-qzm9wgde	103	2	two	two	CD
cord-336510-qzm9wgde	103	3	routes	route	NNS
cord-336510-qzm9wgde	103	4	of	of	IN
cord-336510-qzm9wgde	103	5	viral	viral	JJ
cord-336510-qzm9wgde	103	6	egress	egress	NN
cord-336510-qzm9wgde	103	7	are	be	VBP
cord-336510-qzm9wgde	103	8	possible	possible	JJ
cord-336510-qzm9wgde	103	9	[	[	-LRB-
cord-336510-qzm9wgde	103	10	11	11	CD
cord-336510-qzm9wgde	103	11	]	]	-RRB-
cord-336510-qzm9wgde	103	12	.	.	.
cord-336510-qzm9wgde	104	1	One	one	CD
cord-336510-qzm9wgde	104	2	way	way	NN
cord-336510-qzm9wgde	104	3	is	be	VBZ
cord-336510-qzm9wgde	104	4	by	by	IN
cord-336510-qzm9wgde	104	5	continuous	continuous	JJ
cord-336510-qzm9wgde	104	6	passage	passage	NN
cord-336510-qzm9wgde	104	7	through	through	IN
cord-336510-qzm9wgde	104	8	vesicles	vesicle	NNS
cord-336510-qzm9wgde	104	9	and	and	CC
cord-336510-qzm9wgde	104	10	the	the	DT
cord-336510-qzm9wgde	104	11	Golgi	Golgi	NNP
cord-336510-qzm9wgde	104	12	apparatus	apparatus	NN
cord-336510-qzm9wgde	104	13	,	,	,
cord-336510-qzm9wgde	104	14	where	where	WRB
cord-336510-qzm9wgde	104	15	the	the	DT
cord-336510-qzm9wgde	104	16	membrane	membrane	NN
cord-336510-qzm9wgde	104	17	proteins	protein	NNS
cord-336510-qzm9wgde	104	18	are	be	VBP
cord-336510-qzm9wgde	104	19	modified	modify	VBN
cord-336510-qzm9wgde	104	20	.	.	.
cord-336510-qzm9wgde	105	1	The	the	DT
cord-336510-qzm9wgde	105	2	other	other	JJ
cord-336510-qzm9wgde	105	3	route	route	NN
cord-336510-qzm9wgde	105	4	is	be	VBZ
cord-336510-qzm9wgde	105	5	by	by	IN
cord-336510-qzm9wgde	105	6	fusion	fusion	NN
cord-336510-qzm9wgde	105	7	of	of	IN
cord-336510-qzm9wgde	105	8	the	the	DT
cord-336510-qzm9wgde	105	9	newly	newly	RB
cord-336510-qzm9wgde	105	10	acquired	acquire	VBN
cord-336510-qzm9wgde	105	11	envelope	envelope	NN
cord-336510-qzm9wgde	105	12	with	with	IN
cord-336510-qzm9wgde	105	13	the	the	DT
cord-336510-qzm9wgde	105	14	outer	outer	JJ
cord-336510-qzm9wgde	105	15	nuclear	nuclear	JJ
cord-336510-qzm9wgde	105	16	membrane	membrane	NN
cord-336510-qzm9wgde	105	17	or	or	CC
cord-336510-qzm9wgde	105	18	the	the	DT
cord-336510-qzm9wgde	105	19	membrane	membrane	NN
cord-336510-qzm9wgde	105	20	of	of	IN
cord-336510-qzm9wgde	105	21	a	a	DT
cord-336510-qzm9wgde	105	22	vesicle	vesicle	NN
cord-336510-qzm9wgde	105	23	,	,	,
cord-336510-qzm9wgde	105	24	generating	generate	VBG
cord-336510-qzm9wgde	105	25	naked	naked	JJ
cord-336510-qzm9wgde	105	26	nucleocapsids	nucleocapsid	NNS
cord-336510-qzm9wgde	105	27	in	in	IN
cord-336510-qzm9wgde	105	28	the	the	DT
cord-336510-qzm9wgde	105	29	cytoplasm	cytoplasm	NN
cord-336510-qzm9wgde	105	30	.	.	.
cord-336510-qzm9wgde	106	1	From	from	IN
cord-336510-qzm9wgde	106	2	here	here	RB
cord-336510-qzm9wgde	106	3	a	a	DT
cord-336510-qzm9wgde	106	4	new	new	JJ
cord-336510-qzm9wgde	106	5	budding	bud	VBG
cord-336510-qzm9wgde	106	6	event	event	NN
cord-336510-qzm9wgde	106	7	should	should	MD
cord-336510-qzm9wgde	106	8	take	take	VB
cord-336510-qzm9wgde	106	9	place	place	NN
cord-336510-qzm9wgde	106	10	,	,	,
cord-336510-qzm9wgde	106	11	for	for	IN
cord-336510-qzm9wgde	106	12	instance	instance	NN
cord-336510-qzm9wgde	106	13	into	into	IN
cord-336510-qzm9wgde	106	14	the	the	DT
cord-336510-qzm9wgde	106	15	Golgi	Golgi	NNP
cord-336510-qzm9wgde	106	16	apparatus	apparatus	NN
cord-336510-qzm9wgde	106	17	.	.	.
cord-336510-qzm9wgde	107	1	The	the	DT
cord-336510-qzm9wgde	107	2	progeny	progeny	JJ
cord-336510-qzm9wgde	107	3	virus	virus	NN
cord-336510-qzm9wgde	107	4	thus	thus	RB
cord-336510-qzm9wgde	107	5	acquires	acquire	VBZ
cord-336510-qzm9wgde	107	6	the	the	DT
cord-336510-qzm9wgde	107	7	envelope	envelope	NN
cord-336510-qzm9wgde	107	8	from	from	IN
cord-336510-qzm9wgde	107	9	other	other	JJ
cord-336510-qzm9wgde	107	10	membranes	membrane	NNS
cord-336510-qzm9wgde	107	11	,	,	,
cord-336510-qzm9wgde	107	12	than	than	IN
cord-336510-qzm9wgde	107	13	the	the	DT
cord-336510-qzm9wgde	107	14	inner	inner	JJ
cord-336510-qzm9wgde	107	15	nuclear	nuclear	JJ
cord-336510-qzm9wgde	107	16	lamella	lamella	NN
cord-336510-qzm9wgde	107	17	,	,	,
cord-336510-qzm9wgde	107	18	as	as	IN
cord-336510-qzm9wgde	107	19	it	-PRON-	PRP
cord-336510-qzm9wgde	107	20	is	be	VBZ
cord-336510-qzm9wgde	107	21	indicated	indicate	VBN
cord-336510-qzm9wgde	107	22	by	by	IN
cord-336510-qzm9wgde	107	23	analysis	analysis	NN
cord-336510-qzm9wgde	107	24	of	of	IN
cord-336510-qzm9wgde	107	25	membrane	membrane	NN
cord-336510-qzm9wgde	107	26	lipids	lipid	NNS
cord-336510-qzm9wgde	107	27	[	[	-LRB-
cord-336510-qzm9wgde	107	28	83	83	CD
cord-336510-qzm9wgde	107	29	]	]	-RRB-
cord-336510-qzm9wgde	107	30	.	.	.
cord-336510-qzm9wgde	108	1	Increasing	increase	VBG
cord-336510-qzm9wgde	108	2	evidence	evidence	NN
cord-336510-qzm9wgde	108	3	is	be	VBZ
cord-336510-qzm9wgde	108	4	pointing	point	VBG
cord-336510-qzm9wgde	108	5	at	at	IN
cord-336510-qzm9wgde	108	6	this	this	DT
cord-336510-qzm9wgde	108	7	latter	latter	JJ
cord-336510-qzm9wgde	108	8	possibility	possibility	NN
cord-336510-qzm9wgde	108	9	of	of	IN
cord-336510-qzm9wgde	108	10	de	de	NN
cord-336510-qzm9wgde	108	11	-	-	NN
cord-336510-qzm9wgde	108	12	envelopment	envelopment	NN
cord-336510-qzm9wgde	108	13	and	and	CC
cord-336510-qzm9wgde	108	14	re	re	NN
cord-336510-qzm9wgde	108	15	-	-	NN
cord-336510-qzm9wgde	108	16	envelopment	envelopment	NN
cord-336510-qzm9wgde	108	17	as	as	IN
cord-336510-qzm9wgde	108	18	the	the	DT
cord-336510-qzm9wgde	108	19	dominating	dominating	JJ
cord-336510-qzm9wgde	108	20	route	route	NN
cord-336510-qzm9wgde	108	21	of	of	IN
cord-336510-qzm9wgde	108	22	HSV	HSV	NNP
cord-336510-qzm9wgde	108	23	egress	egress	NN
cord-336510-qzm9wgde	108	24	[	[	-LRB-
cord-336510-qzm9wgde	108	25	84	84	CD
cord-336510-qzm9wgde	108	26	-	-	SYM
cord-336510-qzm9wgde	108	27	86	86	CD
cord-336510-qzm9wgde	108	28	]	]	-RRB-
cord-336510-qzm9wgde	108	29	.	.	.
cord-336510-qzm9wgde	109	1	The	the	DT
cord-336510-qzm9wgde	109	2	progress	progress	NN
cord-336510-qzm9wgde	109	3	of	of	IN
cord-336510-qzm9wgde	109	4	HSV	HSV	NNP
cord-336510-qzm9wgde	109	5	infection	infection	NN
cord-336510-qzm9wgde	109	6	in	in	IN
cord-336510-qzm9wgde	109	7	tissues	tissue	NNS
cord-336510-qzm9wgde	109	8	is	be	VBZ
cord-336510-qzm9wgde	109	9	influenced	influence	VBN
cord-336510-qzm9wgde	109	10	by	by	IN
cord-336510-qzm9wgde	109	11	the	the	DT
cord-336510-qzm9wgde	109	12	capacity	capacity	NN
cord-336510-qzm9wgde	109	13	of	of	IN
cord-336510-qzm9wgde	109	14	HSV	HSV	NNP
cord-336510-qzm9wgde	109	15	to	to	TO
cord-336510-qzm9wgde	109	16	infect	infect	VB
cord-336510-qzm9wgde	109	17	adjacent	adjacent	JJ
cord-336510-qzm9wgde	109	18	cells	cell	NNS
cord-336510-qzm9wgde	109	19	directly	directly	RB
cord-336510-qzm9wgde	109	20	through	through	IN
cord-336510-qzm9wgde	109	21	cell	cell	NN
cord-336510-qzm9wgde	109	22	junctions	junction	NNS
cord-336510-qzm9wgde	109	23	.	.	.
cord-336510-qzm9wgde	110	1	The	the	DT
cord-336510-qzm9wgde	110	2	virus	virus	NN
cord-336510-qzm9wgde	110	3	is	be	VBZ
cord-336510-qzm9wgde	110	4	thus	thus	RB
cord-336510-qzm9wgde	110	5	avoiding	avoid	VBG
cord-336510-qzm9wgde	110	6	exposure	exposure	NN
cord-336510-qzm9wgde	110	7	to	to	IN
cord-336510-qzm9wgde	110	8	extracellular	extracellular	JJ
cord-336510-qzm9wgde	110	9	substances	substance	NNS
cord-336510-qzm9wgde	110	10	such	such	JJ
cord-336510-qzm9wgde	110	11	as	as	IN
cord-336510-qzm9wgde	110	12	antibodies	antibody	NNS
cord-336510-qzm9wgde	110	13	and	and	CC
cord-336510-qzm9wgde	110	14	complement	complement	VBP
cord-336510-qzm9wgde	110	15	.	.	.
cord-336510-qzm9wgde	111	1	The	the	DT
cord-336510-qzm9wgde	111	2	glycoproteins	glycoprotein	NNS
cord-336510-qzm9wgde	111	3	gE	gE	NNP
cord-336510-qzm9wgde	111	4	and	and	CC
cord-336510-qzm9wgde	111	5	gI	gI	NNP
cord-336510-qzm9wgde	111	6	are	be	VBP
cord-336510-qzm9wgde	111	7	crucial	crucial	JJ
cord-336510-qzm9wgde	111	8	for	for	IN
cord-336510-qzm9wgde	111	9	this	this	DT
cord-336510-qzm9wgde	111	10	kind	kind	NN
cord-336510-qzm9wgde	111	11	of	of	IN
cord-336510-qzm9wgde	111	12	polarised	polarised	JJ
cord-336510-qzm9wgde	111	13	transmission	transmission	NN
cord-336510-qzm9wgde	111	14	which	which	WDT
cord-336510-qzm9wgde	111	15	primarily	primarily	RB
cord-336510-qzm9wgde	111	16	takes	take	VBZ
cord-336510-qzm9wgde	111	17	place	place	NN
cord-336510-qzm9wgde	111	18	in	in	IN
cord-336510-qzm9wgde	111	19	epithelial	epithelial	JJ
cord-336510-qzm9wgde	111	20	infections	infection	NNS
cord-336510-qzm9wgde	111	21	[	[	-LRB-
cord-336510-qzm9wgde	111	22	47	47	CD
cord-336510-qzm9wgde	111	23	,	,	,
cord-336510-qzm9wgde	111	24	87	87	CD
cord-336510-qzm9wgde	111	25	]	]	-RRB-
cord-336510-qzm9wgde	111	26	.	.	.
cord-336510-qzm9wgde	112	1	As	as	IN
cord-336510-qzm9wgde	112	2	it	-PRON-	PRP
cord-336510-qzm9wgde	112	3	is	be	VBZ
cord-336510-qzm9wgde	112	4	the	the	DT
cord-336510-qzm9wgde	112	5	case	case	NN
cord-336510-qzm9wgde	112	6	at	at	IN
cord-336510-qzm9wgde	112	7	the	the	DT
cord-336510-qzm9wgde	112	8	molecular	molecular	JJ
cord-336510-qzm9wgde	112	9	level	level	NN
cord-336510-qzm9wgde	112	10	,	,	,
cord-336510-qzm9wgde	112	11	the	the	DT
cord-336510-qzm9wgde	112	12	two	two	CD
cord-336510-qzm9wgde	112	13	herpes	herpe	NNS
cord-336510-qzm9wgde	112	14	simplex	simplex	NN
cord-336510-qzm9wgde	112	15	viruses	virus	NNS
cord-336510-qzm9wgde	112	16	show	show	VBP
cord-336510-qzm9wgde	112	17	similarities	similarity	NNS
cord-336510-qzm9wgde	112	18	in	in	IN
cord-336510-qzm9wgde	112	19	their	-PRON-	PRP$
cord-336510-qzm9wgde	112	20	clinical	clinical	JJ
cord-336510-qzm9wgde	112	21	appearance	appearance	NN
cord-336510-qzm9wgde	112	22	,	,	,
cord-336510-qzm9wgde	112	23	both	both	DT
cord-336510-qzm9wgde	112	24	giving	give	VBG
cord-336510-qzm9wgde	112	25	rise	rise	NN
cord-336510-qzm9wgde	112	26	to	to	IN
cord-336510-qzm9wgde	112	27	primary	primary	JJ
cord-336510-qzm9wgde	112	28	infections	infection	NNS
cord-336510-qzm9wgde	112	29	of	of	IN
cord-336510-qzm9wgde	112	30	mucosal	mucosal	JJ
cord-336510-qzm9wgde	112	31	membranes	membrane	NNS
cord-336510-qzm9wgde	112	32	and	and	CC
cord-336510-qzm9wgde	112	33	showing	show	VBG
cord-336510-qzm9wgde	112	34	latency	latency	NN
cord-336510-qzm9wgde	112	35	in	in	IN
cord-336510-qzm9wgde	112	36	sensory	sensory	JJ
cord-336510-qzm9wgde	112	37	nerve	nerve	NN
cord-336510-qzm9wgde	112	38	ganglia	ganglion	NNS
cord-336510-qzm9wgde	112	39	[	[	-LRB-
cord-336510-qzm9wgde	112	40	1	1	CD
cord-336510-qzm9wgde	112	41	]	]	-RRB-
cord-336510-qzm9wgde	112	42	.	.	.
cord-336510-qzm9wgde	113	1	The	the	DT
cord-336510-qzm9wgde	113	2	primary	primary	JJ
cord-336510-qzm9wgde	113	3	infections	infection	NNS
cord-336510-qzm9wgde	113	4	with	with	IN
cord-336510-qzm9wgde	113	5	HSV	HSV	NNP
cord-336510-qzm9wgde	113	6	are	be	VBP
cord-336510-qzm9wgde	113	7	often	often	RB
cord-336510-qzm9wgde	113	8	asymptomatic	asymptomatic	JJ
cord-336510-qzm9wgde	113	9	,	,	,
cord-336510-qzm9wgde	113	10	especially	especially	RB
cord-336510-qzm9wgde	113	11	at	at	IN
cord-336510-qzm9wgde	113	12	young	young	JJ
cord-336510-qzm9wgde	113	13	age	age	NN
cord-336510-qzm9wgde	113	14	,	,	,
cord-336510-qzm9wgde	113	15	but	but	CC
cord-336510-qzm9wgde	113	16	in	in	IN
cord-336510-qzm9wgde	113	17	a	a	DT
cord-336510-qzm9wgde	113	18	minority	minority	NN
cord-336510-qzm9wgde	113	19	of	of	IN
cord-336510-qzm9wgde	113	20	cases	case	NNS
cord-336510-qzm9wgde	113	21	vesicular	vesicular	JJ
cord-336510-qzm9wgde	113	22	or	or	CC
cord-336510-qzm9wgde	113	23	ulcerative	ulcerative	JJ
cord-336510-qzm9wgde	113	24	lesions	lesion	NNS
cord-336510-qzm9wgde	113	25	are	be	VBP
cord-336510-qzm9wgde	113	26	seen	see	VBN
cord-336510-qzm9wgde	113	27	.	.	.
cord-336510-qzm9wgde	114	1	Although	although	IN
cord-336510-qzm9wgde	114	2	HSV-1	HSV-1	NNP
cord-336510-qzm9wgde	114	3	and	and	CC
cord-336510-qzm9wgde	114	4	-2	-2	NNP
cord-336510-qzm9wgde	114	5	can	can	MD
cord-336510-qzm9wgde	114	6	give	give	VB
cord-336510-qzm9wgde	114	7	rise	rise	NN
cord-336510-qzm9wgde	114	8	to	to	IN
cord-336510-qzm9wgde	114	9	indistinguishable	indistinguishable	JJ
cord-336510-qzm9wgde	114	10	clinical	clinical	JJ
cord-336510-qzm9wgde	114	11	infections	infection	NNS
cord-336510-qzm9wgde	114	12	,	,	,
cord-336510-qzm9wgde	114	13	there	there	EX
cord-336510-qzm9wgde	114	14	are	be	VBP
cord-336510-qzm9wgde	114	15	differences	difference	NNS
cord-336510-qzm9wgde	114	16	in	in	IN
cord-336510-qzm9wgde	114	17	the	the	DT
cord-336510-qzm9wgde	114	18	anatomical	anatomical	JJ
cord-336510-qzm9wgde	114	19	distribution	distribution	NN
cord-336510-qzm9wgde	114	20	of	of	IN
cord-336510-qzm9wgde	114	21	these	these	DT
cord-336510-qzm9wgde	114	22	infections	infection	NNS
cord-336510-qzm9wgde	114	23	,	,	,
cord-336510-qzm9wgde	114	24	as	as	IN
cord-336510-qzm9wgde	114	25	described	describe	VBN
cord-336510-qzm9wgde	114	26	in	in	IN
cord-336510-qzm9wgde	114	27	1967	1967	CD
cord-336510-qzm9wgde	114	28	by	by	IN
cord-336510-qzm9wgde	114	29	Dowdle	Dowdle	NNP
cord-336510-qzm9wgde	114	30	et	et	NNP
cord-336510-qzm9wgde	114	31	al	al	NNP
cord-336510-qzm9wgde	114	32	.	.	.
cord-336510-qzm9wgde	115	1	[	[	-LRB-
cord-336510-qzm9wgde	115	2	88	88	CD
cord-336510-qzm9wgde	115	3	]	]	-RRB-
cord-336510-qzm9wgde	115	4	.	.	.
cord-336510-qzm9wgde	116	1	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	116	2	is	be	VBZ
cord-336510-qzm9wgde	116	3	predominantly	predominantly	RB
cord-336510-qzm9wgde	116	4	giving	give	VBG
cord-336510-qzm9wgde	116	5	rise	rise	NN
cord-336510-qzm9wgde	116	6	to	to	IN
cord-336510-qzm9wgde	116	7	infections	infection	NNS
cord-336510-qzm9wgde	116	8	above	above	IN
cord-336510-qzm9wgde	116	9	the	the	DT
cord-336510-qzm9wgde	116	10	waist	waist	NN
cord-336510-qzm9wgde	116	11	,	,	,
cord-336510-qzm9wgde	116	12	and	and	CC
cord-336510-qzm9wgde	116	13	HSV-2	HSV-2	NNPS
cord-336510-qzm9wgde	116	14	to	to	IN
cord-336510-qzm9wgde	116	15	infections	infection	NNS
cord-336510-qzm9wgde	116	16	below	below	IN
cord-336510-qzm9wgde	116	17	the	the	DT
cord-336510-qzm9wgde	116	18	waist	waist	NN
cord-336510-qzm9wgde	116	19	.	.	.
cord-336510-qzm9wgde	117	1	This	this	DT
cord-336510-qzm9wgde	117	2	pattern	pattern	NN
cord-336510-qzm9wgde	117	3	is	be	VBZ
cord-336510-qzm9wgde	117	4	,	,	,
cord-336510-qzm9wgde	117	5	however	however	RB
cord-336510-qzm9wgde	117	6	,	,	,
cord-336510-qzm9wgde	117	7	not	not	RB
cord-336510-qzm9wgde	117	8	as	as	RB
cord-336510-qzm9wgde	117	9	straightforward	straightforward	JJ
cord-336510-qzm9wgde	117	10	as	as	IN
cord-336510-qzm9wgde	117	11	primarily	primarily	RB
cord-336510-qzm9wgde	117	12	described	describe	VBN
cord-336510-qzm9wgde	117	13	.	.	.
cord-336510-qzm9wgde	118	1	In	in	IN
cord-336510-qzm9wgde	118	2	the	the	DT
cord-336510-qzm9wgde	118	3	last	last	JJ
cord-336510-qzm9wgde	118	4	decades	decade	NNS
cord-336510-qzm9wgde	118	5	changes	change	VBZ
cord-336510-qzm9wgde	118	6	in	in	IN
cord-336510-qzm9wgde	118	7	both	both	DT
cord-336510-qzm9wgde	118	8	prevalence	prevalence	NN
cord-336510-qzm9wgde	118	9	and	and	CC
cord-336510-qzm9wgde	118	10	distribution	distribution	NN
cord-336510-qzm9wgde	118	11	of	of	IN
cord-336510-qzm9wgde	118	12	HSV	HSV	NNP
cord-336510-qzm9wgde	118	13	infections	infection	NNS
cord-336510-qzm9wgde	118	14	have	have	VBP
cord-336510-qzm9wgde	118	15	been	be	VBN
cord-336510-qzm9wgde	118	16	seen	see	VBN
cord-336510-qzm9wgde	118	17	.	.	.
cord-336510-qzm9wgde	119	1	The	the	DT
cord-336510-qzm9wgde	119	2	overall	overall	JJ
cord-336510-qzm9wgde	119	3	prevalence	prevalence	NN
cord-336510-qzm9wgde	119	4	of	of	IN
cord-336510-qzm9wgde	119	5	HSV	HSV	NNP
cord-336510-qzm9wgde	119	6	infection	infection	NN
cord-336510-qzm9wgde	119	7	is	be	VBZ
cord-336510-qzm9wgde	119	8	very	very	RB
cord-336510-qzm9wgde	119	9	different	different	JJ
cord-336510-qzm9wgde	119	10	in	in	IN
cord-336510-qzm9wgde	119	11	different	different	JJ
cord-336510-qzm9wgde	119	12	countries	country	NNS
cord-336510-qzm9wgde	119	13	and	and	CC
cord-336510-qzm9wgde	119	14	ethnic	ethnic	JJ
cord-336510-qzm9wgde	119	15	and	and	CC
cord-336510-qzm9wgde	119	16	social	social	JJ
cord-336510-qzm9wgde	119	17	populations	population	NNS
cord-336510-qzm9wgde	119	18	[	[	-LRB-
cord-336510-qzm9wgde	119	19	89	89	CD
cord-336510-qzm9wgde	119	20	]	]	-RRB-
cord-336510-qzm9wgde	119	21	[	[	-LRB-
cord-336510-qzm9wgde	119	22	90	90	CD
cord-336510-qzm9wgde	119	23	]	]	-RRB-
cord-336510-qzm9wgde	119	24	[	[	-LRB-
cord-336510-qzm9wgde	119	25	91	91	CD
cord-336510-qzm9wgde	119	26	]	]	-RRB-
cord-336510-qzm9wgde	119	27	.	.	.
cord-336510-qzm9wgde	120	1	A	a	DT
cord-336510-qzm9wgde	120	2	decline	decline	NN
cord-336510-qzm9wgde	120	3	in	in	IN
cord-336510-qzm9wgde	120	4	HSV	HSV	NNP
cord-336510-qzm9wgde	120	5	prevalence	prevalence	NN
cord-336510-qzm9wgde	120	6	has	have	VBZ
cord-336510-qzm9wgde	120	7	been	be	VBN
cord-336510-qzm9wgde	120	8	observed	observe	VBN
cord-336510-qzm9wgde	120	9	in	in	IN
cord-336510-qzm9wgde	120	10	the	the	DT
cord-336510-qzm9wgde	120	11	western	western	JJ
cord-336510-qzm9wgde	120	12	countries	country	NNS
cord-336510-qzm9wgde	120	13	,	,	,
cord-336510-qzm9wgde	120	14	probably	probably	RB
cord-336510-qzm9wgde	120	15	because	because	IN
cord-336510-qzm9wgde	120	16	of	of	IN
cord-336510-qzm9wgde	120	17	improved	improve	VBN
cord-336510-qzm9wgde	120	18	socioeconomic	socioeconomic	JJ
cord-336510-qzm9wgde	120	19	conditions	condition	NNS
cord-336510-qzm9wgde	120	20	[	[	-LRB-
cord-336510-qzm9wgde	120	21	92	92	CD
cord-336510-qzm9wgde	120	22	]	]	-RRB-
cord-336510-qzm9wgde	121	1	[	[	-LRB-
cord-336510-qzm9wgde	121	2	93	93	CD
cord-336510-qzm9wgde	121	3	]	]	-RRB-
cord-336510-qzm9wgde	121	4	[	[	-LRB-
cord-336510-qzm9wgde	121	5	94	94	CD
cord-336510-qzm9wgde	121	6	]	]	-RRB-
cord-336510-qzm9wgde	121	7	.	.	.
cord-336510-qzm9wgde	122	1	In	in	IN
cord-336510-qzm9wgde	122	2	parallel	parallel	NN
cord-336510-qzm9wgde	122	3	to	to	IN
cord-336510-qzm9wgde	122	4	the	the	DT
cord-336510-qzm9wgde	122	5	decline	decline	NN
cord-336510-qzm9wgde	122	6	in	in	IN
cord-336510-qzm9wgde	122	7	prevalence	prevalence	NN
cord-336510-qzm9wgde	122	8	,	,	,
cord-336510-qzm9wgde	122	9	the	the	DT
cord-336510-qzm9wgde	122	10	aetiology	aetiology	NN
cord-336510-qzm9wgde	122	11	of	of	IN
cord-336510-qzm9wgde	122	12	herpes	herpes	NNP
cord-336510-qzm9wgde	122	13	genitalis	genitalis	NNP
cord-336510-qzm9wgde	122	14	has	have	VBZ
cord-336510-qzm9wgde	122	15	changed	change	VBN
cord-336510-qzm9wgde	122	16	in	in	IN
cord-336510-qzm9wgde	122	17	several	several	JJ
cord-336510-qzm9wgde	122	18	countries	country	NNS
cord-336510-qzm9wgde	122	19	,	,	,
cord-336510-qzm9wgde	122	20	presumably	presumably	RB
cord-336510-qzm9wgde	122	21	because	because	IN
cord-336510-qzm9wgde	122	22	of	of	IN
cord-336510-qzm9wgde	122	23	altered	alter	VBN
cord-336510-qzm9wgde	122	24	human	human	JJ
cord-336510-qzm9wgde	122	25	habits	habit	NNS
cord-336510-qzm9wgde	122	26	and	and	CC
cord-336510-qzm9wgde	122	27	conditions	condition	NNS
cord-336510-qzm9wgde	122	28	of	of	IN
cord-336510-qzm9wgde	122	29	life	life	NN
cord-336510-qzm9wgde	122	30	[	[	-LRB-
cord-336510-qzm9wgde	122	31	92	92	CD
cord-336510-qzm9wgde	122	32	]	]	-RRB-
cord-336510-qzm9wgde	122	33	.	.	.
cord-336510-qzm9wgde	123	1	In	in	IN
cord-336510-qzm9wgde	123	2	some	some	DT
cord-336510-qzm9wgde	123	3	areas	area	NNS
cord-336510-qzm9wgde	123	4	of	of	IN
cord-336510-qzm9wgde	123	5	the	the	DT
cord-336510-qzm9wgde	123	6	world	world	NN
cord-336510-qzm9wgde	123	7	the	the	DT
cord-336510-qzm9wgde	123	8	proportion	proportion	NN
cord-336510-qzm9wgde	123	9	of	of	IN
cord-336510-qzm9wgde	123	10	genital	genital	JJ
cord-336510-qzm9wgde	123	11	infections	infection	NNS
cord-336510-qzm9wgde	123	12	caused	cause	VBN
cord-336510-qzm9wgde	123	13	by	by	IN
cord-336510-qzm9wgde	123	14	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	123	15	is	be	VBZ
cord-336510-qzm9wgde	123	16	still	still	RB
cord-336510-qzm9wgde	123	17	low	low	JJ
cord-336510-qzm9wgde	123	18	(	(	-LRB-
cord-336510-qzm9wgde	123	19	4	4	CD
cord-336510-qzm9wgde	123	20	-	-	SYM
cord-336510-qzm9wgde	123	21	20	20	CD
cord-336510-qzm9wgde	123	22	%	%	NN
cord-336510-qzm9wgde	123	23	)	)	-RRB-
cord-336510-qzm9wgde	124	1	The	the	DT
cord-336510-qzm9wgde	124	2	aetiology	aetiology	NN
cord-336510-qzm9wgde	124	3	of	of	IN
cord-336510-qzm9wgde	124	4	a	a	DT
cord-336510-qzm9wgde	124	5	genital	genital	JJ
cord-336510-qzm9wgde	124	6	infection	infection	NN
cord-336510-qzm9wgde	124	7	is	be	VBZ
cord-336510-qzm9wgde	124	8	not	not	RB
cord-336510-qzm9wgde	124	9	insignificant	insignificant	JJ
cord-336510-qzm9wgde	124	10	,	,	,
cord-336510-qzm9wgde	124	11	in	in	IN
cord-336510-qzm9wgde	124	12	that	that	IN
cord-336510-qzm9wgde	124	13	the	the	DT
cord-336510-qzm9wgde	124	14	frequency	frequency	NN
cord-336510-qzm9wgde	124	15	of	of	IN
cord-336510-qzm9wgde	124	16	recurrence	recurrence	NN
cord-336510-qzm9wgde	124	17	is	be	VBZ
cord-336510-qzm9wgde	124	18	higher	high	JJR
cord-336510-qzm9wgde	124	19	in	in	IN
cord-336510-qzm9wgde	124	20	HSV	HSV	NNP
cord-336510-qzm9wgde	124	21	type	type	NN
cord-336510-qzm9wgde	124	22	2infected	2infected	CD
cord-336510-qzm9wgde	124	23	individuals	individual	NNS
cord-336510-qzm9wgde	124	24	than	than	IN
cord-336510-qzm9wgde	124	25	in	in	IN
cord-336510-qzm9wgde	124	26	those	those	DT
cord-336510-qzm9wgde	124	27	infected	infect	VBN
cord-336510-qzm9wgde	124	28	with	with	IN
cord-336510-qzm9wgde	124	29	type	type	NN
cord-336510-qzm9wgde	124	30	1	1	CD
cord-336510-qzm9wgde	124	31	[	[	-LRB-
cord-336510-qzm9wgde	124	32	89	89	CD
cord-336510-qzm9wgde	124	33	,	,	,
cord-336510-qzm9wgde	124	34	95	95	CD
cord-336510-qzm9wgde	124	35	]	]	-RRB-
cord-336510-qzm9wgde	124	36	.	.	.
cord-336510-qzm9wgde	125	1	The	the	DT
cord-336510-qzm9wgde	125	2	frequency	frequency	NN
cord-336510-qzm9wgde	125	3	of	of	IN
cord-336510-qzm9wgde	125	4	primary	primary	JJ
cord-336510-qzm9wgde	125	5	and	and	CC
cord-336510-qzm9wgde	125	6	recurrent	recurrent	JJ
cord-336510-qzm9wgde	125	7	infections	infection	NNS
cord-336510-qzm9wgde	125	8	with	with	IN
cord-336510-qzm9wgde	125	9	both	both	CC
cord-336510-qzm9wgde	125	10	HSV-1	HSV-1	NNS
cord-336510-qzm9wgde	125	11	and	and	CC
cord-336510-qzm9wgde	125	12	-2	-2	NNP
cord-336510-qzm9wgde	125	13	has	have	VBZ
cord-336510-qzm9wgde	125	14	been	be	VBN
cord-336510-qzm9wgde	125	15	reported	report	VBN
cord-336510-qzm9wgde	125	16	to	to	TO
cord-336510-qzm9wgde	125	17	be	be	VB
cord-336510-qzm9wgde	125	18	higher	high	JJR
cord-336510-qzm9wgde	125	19	among	among	IN
cord-336510-qzm9wgde	125	20	women	woman	NNS
cord-336510-qzm9wgde	125	21	than	than	IN
cord-336510-qzm9wgde	125	22	men	man	NNS
cord-336510-qzm9wgde	125	23	[	[	-LRB-
cord-336510-qzm9wgde	125	24	97	97	CD
cord-336510-qzm9wgde	125	25	,	,	,
cord-336510-qzm9wgde	125	26	103	103	CD
cord-336510-qzm9wgde	125	27	,	,	,
cord-336510-qzm9wgde	125	28	105	105	CD
cord-336510-qzm9wgde	125	29	]	]	-RRB-
cord-336510-qzm9wgde	125	30	.	.	.
cord-336510-qzm9wgde	126	1	Overall	overall	RB
cord-336510-qzm9wgde	126	2	,	,	,
cord-336510-qzm9wgde	126	3	these	these	DT
cord-336510-qzm9wgde	126	4	epidemiological	epidemiological	JJ
cord-336510-qzm9wgde	126	5	changes	change	NNS
cord-336510-qzm9wgde	126	6	could	could	MD
cord-336510-qzm9wgde	126	7	have	have	VB
cord-336510-qzm9wgde	126	8	implications	implication	NNS
cord-336510-qzm9wgde	126	9	for	for	IN
cord-336510-qzm9wgde	126	10	the	the	DT
cord-336510-qzm9wgde	126	11	risk	risk	NN
cord-336510-qzm9wgde	126	12	of	of	IN
cord-336510-qzm9wgde	126	13	neonatal	neonatal	JJ
cord-336510-qzm9wgde	126	14	infection	infection	NN
cord-336510-qzm9wgde	126	15	from	from	IN
cord-336510-qzm9wgde	126	16	vaginal	vaginal	JJ
cord-336510-qzm9wgde	126	17	delivery	delivery	NN
cord-336510-qzm9wgde	126	18	,	,	,
cord-336510-qzm9wgde	126	19	in	in	IN
cord-336510-qzm9wgde	126	20	that	that	DT
cord-336510-qzm9wgde	126	21	more	more	JJR
cord-336510-qzm9wgde	126	22	women	woman	NNS
cord-336510-qzm9wgde	126	23	are	be	VBP
cord-336510-qzm9wgde	126	24	seronegative	seronegative	JJ
cord-336510-qzm9wgde	126	25	at	at	IN
cord-336510-qzm9wgde	126	26	delivery	delivery	NN
cord-336510-qzm9wgde	126	27	and	and	CC
cord-336510-qzm9wgde	126	28	thus	thus	RB
cord-336510-qzm9wgde	126	29	a	a	DT
cord-336510-qzm9wgde	126	30	higher	high	JJR
cord-336510-qzm9wgde	126	31	number	number	NN
cord-336510-qzm9wgde	126	32	have	have	VBP
cord-336510-qzm9wgde	126	33	the	the	DT
cord-336510-qzm9wgde	126	34	risk	risk	NN
cord-336510-qzm9wgde	126	35	of	of	IN
cord-336510-qzm9wgde	126	36	caching	cache	VBG
cord-336510-qzm9wgde	126	37	a	a	DT
cord-336510-qzm9wgde	126	38	primary	primary	JJ
cord-336510-qzm9wgde	126	39	HSV	HSV	NNP
cord-336510-qzm9wgde	126	40	infection	infection	NN
cord-336510-qzm9wgde	126	41	.	.	.
cord-336510-qzm9wgde	127	1	On	on	IN
cord-336510-qzm9wgde	127	2	the	the	DT
cord-336510-qzm9wgde	127	3	other	other	JJ
cord-336510-qzm9wgde	127	4	hand	hand	NN
cord-336510-qzm9wgde	127	5	,	,	,
cord-336510-qzm9wgde	127	6	less	less	JJR
cord-336510-qzm9wgde	127	7	HSV	HSV	NNP
cord-336510-qzm9wgde	127	8	is	be	VBZ
cord-336510-qzm9wgde	127	9	circulating	circulate	VBG
cord-336510-qzm9wgde	127	10	,	,	,
cord-336510-qzm9wgde	127	11	reducing	reduce	VBG
cord-336510-qzm9wgde	127	12	the	the	DT
cord-336510-qzm9wgde	127	13	risk	risk	NN
cord-336510-qzm9wgde	127	14	of	of	IN
cord-336510-qzm9wgde	127	15	those	those	DT
cord-336510-qzm9wgde	127	16	who	who	WP
cord-336510-qzm9wgde	127	17	are	be	VBP
cord-336510-qzm9wgde	127	18	susceptible	susceptible	JJ
cord-336510-qzm9wgde	127	19	.	.	.
cord-336510-qzm9wgde	128	1	Clinical	clinical	JJ
cord-336510-qzm9wgde	128	2	appearance	appearance	NN
cord-336510-qzm9wgde	128	3	and	and	CC
cord-336510-qzm9wgde	128	4	pathogenesis	pathogenesis	NN
cord-336510-qzm9wgde	129	1	As	as	IN
cord-336510-qzm9wgde	129	2	described	describe	VBN
cord-336510-qzm9wgde	129	3	above	above	RB
cord-336510-qzm9wgde	129	4	,	,	,
cord-336510-qzm9wgde	129	5	primary	primary	JJ
cord-336510-qzm9wgde	129	6	infection	infection	NN
cord-336510-qzm9wgde	129	7	with	with	IN
cord-336510-qzm9wgde	129	8	HSV	HSV	NNP
cord-336510-qzm9wgde	129	9	is	be	VBZ
cord-336510-qzm9wgde	129	10	most	most	RBS
cord-336510-qzm9wgde	129	11	often	often	RB
cord-336510-qzm9wgde	129	12	asymptomatic	asymptomatic	JJ
cord-336510-qzm9wgde	129	13	,	,	,
cord-336510-qzm9wgde	129	14	especially	especially	RB
cord-336510-qzm9wgde	129	15	in	in	IN
cord-336510-qzm9wgde	129	16	younger	young	JJR
cord-336510-qzm9wgde	129	17	children	child	NNS
cord-336510-qzm9wgde	129	18	[	[	-LRB-
cord-336510-qzm9wgde	129	19	106	106	CD
cord-336510-qzm9wgde	129	20	]	]	-RRB-
cord-336510-qzm9wgde	129	21	.	.	.
cord-336510-qzm9wgde	130	1	However	however	RB
cord-336510-qzm9wgde	130	2	,	,	,
cord-336510-qzm9wgde	130	3	some	some	DT
cord-336510-qzm9wgde	130	4	individuals	individual	NNS
cord-336510-qzm9wgde	130	5	experience	experience	VBP
cord-336510-qzm9wgde	130	6	a	a	DT
cord-336510-qzm9wgde	130	7	symptomatic	symptomatic	JJ
cord-336510-qzm9wgde	130	8	primary	primary	JJ
cord-336510-qzm9wgde	130	9	infection	infection	NN
cord-336510-qzm9wgde	130	10	with	with	IN
cord-336510-qzm9wgde	130	11	vesicular	vesicular	JJ
cord-336510-qzm9wgde	130	12	herpetic	herpetic	JJ
cord-336510-qzm9wgde	130	13	gingivostomatitis	gingivostomatitis	RB
cord-336510-qzm9wgde	130	14	or	or	CC
cord-336510-qzm9wgde	130	15	in	in	IN
cord-336510-qzm9wgde	130	16	adolescence	adolescence	NN
cord-336510-qzm9wgde	130	17	more	more	RBR
cord-336510-qzm9wgde	130	18	often	often	RB
cord-336510-qzm9wgde	130	19	a	a	DT
cord-336510-qzm9wgde	130	20	pharyngitis	pharyngitis	NN
cord-336510-qzm9wgde	130	21	[	[	-LRB-
cord-336510-qzm9wgde	130	22	107	107	CD
cord-336510-qzm9wgde	130	23	]	]	-RRB-
cord-336510-qzm9wgde	130	24	.	.	.
cord-336510-qzm9wgde	131	1	As	as	IN
cord-336510-qzm9wgde	131	2	it	-PRON-	PRP
cord-336510-qzm9wgde	131	3	is	be	VBZ
cord-336510-qzm9wgde	131	4	the	the	DT
cord-336510-qzm9wgde	131	5	case	case	NN
cord-336510-qzm9wgde	131	6	with	with	IN
cord-336510-qzm9wgde	131	7	orofacial	orofacial	JJ
cord-336510-qzm9wgde	131	8	infections	infection	NNS
cord-336510-qzm9wgde	131	9	,	,	,
cord-336510-qzm9wgde	131	10	a	a	DT
cord-336510-qzm9wgde	131	11	primary	primary	JJ
cord-336510-qzm9wgde	131	12	genital	genital	JJ
cord-336510-qzm9wgde	131	13	HSV	hsv	NN
cord-336510-qzm9wgde	131	14	infection	infection	NN
cord-336510-qzm9wgde	131	15	can	can	MD
cord-336510-qzm9wgde	131	16	be	be	VB
cord-336510-qzm9wgde	131	17	both	both	DT
cord-336510-qzm9wgde	131	18	asymptomatic	asymptomatic	JJ
cord-336510-qzm9wgde	131	19	and	and	CC
cord-336510-qzm9wgde	131	20	symptomatic	symptomatic	JJ
cord-336510-qzm9wgde	131	21	with	with	IN
cord-336510-qzm9wgde	131	22	ulcerative	ulcerative	JJ
cord-336510-qzm9wgde	131	23	lesions	lesion	NNS
cord-336510-qzm9wgde	131	24	and	and	CC
cord-336510-qzm9wgde	131	25	with	with	IN
cord-336510-qzm9wgde	131	26	or	or	CC
cord-336510-qzm9wgde	131	27	without	without	IN
cord-336510-qzm9wgde	131	28	generalized	generalized	JJ
cord-336510-qzm9wgde	131	29	symptoms	symptom	NNS
cord-336510-qzm9wgde	131	30	such	such	JJ
cord-336510-qzm9wgde	131	31	as	as	IN
cord-336510-qzm9wgde	131	32	fever	fever	NN
cord-336510-qzm9wgde	131	33	,	,	,
cord-336510-qzm9wgde	131	34	headache	headache	NN
cord-336510-qzm9wgde	131	35	etc	etc	FW
cord-336510-qzm9wgde	131	36	.	.	.
cord-336510-qzm9wgde	132	1	[	[	-LRB-
cord-336510-qzm9wgde	132	2	108	108	CD
cord-336510-qzm9wgde	132	3	,	,	,
cord-336510-qzm9wgde	132	4	109	109	CD
cord-336510-qzm9wgde	132	5	]	]	-RRB-
cord-336510-qzm9wgde	132	6	.	.	.
cord-336510-qzm9wgde	133	1	Rarely	rarely	RB
cord-336510-qzm9wgde	133	2	,	,	,
cord-336510-qzm9wgde	133	3	the	the	DT
cord-336510-qzm9wgde	133	4	infection	infection	NN
cord-336510-qzm9wgde	133	5	disseminates	disseminate	VBZ
cord-336510-qzm9wgde	133	6	to	to	IN
cord-336510-qzm9wgde	133	7	one	one	CD
cord-336510-qzm9wgde	133	8	or	or	CC
cord-336510-qzm9wgde	133	9	several	several	JJ
cord-336510-qzm9wgde	133	10	organs	organ	NNS
cord-336510-qzm9wgde	133	11	giving	give	VBG
cord-336510-qzm9wgde	133	12	rise	rise	NN
cord-336510-qzm9wgde	133	13	to	to	IN
cord-336510-qzm9wgde	133	14	infections	infection	NNS
cord-336510-qzm9wgde	133	15	such	such	JJ
cord-336510-qzm9wgde	133	16	as	as	IN
cord-336510-qzm9wgde	133	17	necrotising	necrotise	VBG
cord-336510-qzm9wgde	133	18	hepatitis	hepatitis	NN
cord-336510-qzm9wgde	133	19	,	,	,
cord-336510-qzm9wgde	133	20	meningitis	meningitis	NN
cord-336510-qzm9wgde	133	21	,	,	,
cord-336510-qzm9wgde	133	22	encephalitis	encephalitis	JJ
cord-336510-qzm9wgde	133	23	or	or	CC
cord-336510-qzm9wgde	133	24	to	to	IN
cord-336510-qzm9wgde	133	25	disseminated	disseminate	VBN
cord-336510-qzm9wgde	133	26	intravascular	intravascular	JJ
cord-336510-qzm9wgde	133	27	coagulopathy	coagulopathy	NN
cord-336510-qzm9wgde	133	28	[	[	-LRB-
cord-336510-qzm9wgde	133	29	110	110	CD
cord-336510-qzm9wgde	133	30	]	]	-RRB-
cord-336510-qzm9wgde	133	31	[	[	-LRB-
cord-336510-qzm9wgde	133	32	111	111	CD
cord-336510-qzm9wgde	133	33	]	]	-RRB-
cord-336510-qzm9wgde	133	34	[	[	-LRB-
cord-336510-qzm9wgde	133	35	112	112	CD
cord-336510-qzm9wgde	133	36	]	]	-RRB-
cord-336510-qzm9wgde	133	37	[	[	-LRB-
cord-336510-qzm9wgde	133	38	113	113	CD
cord-336510-qzm9wgde	133	39	]	]	-RRB-
cord-336510-qzm9wgde	133	40	.	.	.
cord-336510-qzm9wgde	134	1	Such	such	PDT
cord-336510-qzm9wgde	134	2	a	a	DT
cord-336510-qzm9wgde	134	3	clinical	clinical	JJ
cord-336510-qzm9wgde	134	4	course	course	NN
cord-336510-qzm9wgde	134	5	,	,	,
cord-336510-qzm9wgde	134	6	although	although	IN
cord-336510-qzm9wgde	134	7	uncommon	uncommon	JJ
cord-336510-qzm9wgde	134	8	,	,	,
cord-336510-qzm9wgde	134	9	is	be	VBZ
cord-336510-qzm9wgde	134	10	most	most	RBS
cord-336510-qzm9wgde	134	11	often	often	RB
cord-336510-qzm9wgde	134	12	seen	see	VBN
cord-336510-qzm9wgde	134	13	in	in	IN
cord-336510-qzm9wgde	134	14	immunosuppressed	immunosuppressed	JJ
cord-336510-qzm9wgde	134	15	patients	patient	NNS
cord-336510-qzm9wgde	135	1	e.g.	e.g.	IN
cord-336510-qzm9wgde	135	2	transplant	transplant	NN
cord-336510-qzm9wgde	135	3	patients	patient	NNS
cord-336510-qzm9wgde	135	4	,	,	,
cord-336510-qzm9wgde	135	5	neonates	neonate	NNS
cord-336510-qzm9wgde	135	6	or	or	CC
cord-336510-qzm9wgde	135	7	pregnant	pregnant	JJ
cord-336510-qzm9wgde	135	8	women	woman	NNS
cord-336510-qzm9wgde	135	9	[	[	-LRB-
cord-336510-qzm9wgde	135	10	114	114	CD
cord-336510-qzm9wgde	135	11	]	]	-RRB-
cord-336510-qzm9wgde	135	12	[	[	-LRB-
cord-336510-qzm9wgde	135	13	115	115	CD
cord-336510-qzm9wgde	135	14	]	]	-RRB-
cord-336510-qzm9wgde	135	15	[	[	-LRB-
cord-336510-qzm9wgde	135	16	116	116	CD
cord-336510-qzm9wgde	135	17	]	]	-RRB-
cord-336510-qzm9wgde	135	18	.	.	.
cord-336510-qzm9wgde	136	1	In	in	IN
cord-336510-qzm9wgde	136	2	pregnancy	pregnancy	NN
cord-336510-qzm9wgde	136	3	,	,	,
cord-336510-qzm9wgde	136	4	primary	primary	JJ
cord-336510-qzm9wgde	136	5	infection	infection	NN
cord-336510-qzm9wgde	136	6	with	with	IN
cord-336510-qzm9wgde	136	7	HSV	HSV	NNP
cord-336510-qzm9wgde	136	8	without	without	IN
cord-336510-qzm9wgde	136	9	previous	previous	JJ
cord-336510-qzm9wgde	136	10	seroconversion	seroconversion	NN
cord-336510-qzm9wgde	136	11	at	at	IN
cord-336510-qzm9wgde	136	12	the	the	DT
cord-336510-qzm9wgde	136	13	time	time	NN
cord-336510-qzm9wgde	136	14	of	of	IN
cord-336510-qzm9wgde	136	15	delivery	delivery	NN
cord-336510-qzm9wgde	136	16	seems	seem	VBZ
cord-336510-qzm9wgde	136	17	to	to	TO
cord-336510-qzm9wgde	136	18	be	be	VB
cord-336510-qzm9wgde	136	19	the	the	DT
cord-336510-qzm9wgde	136	20	main	main	JJ
cord-336510-qzm9wgde	136	21	risk	risk	NN
cord-336510-qzm9wgde	136	22	factor	factor	NN
cord-336510-qzm9wgde	136	23	for	for	IN
cord-336510-qzm9wgde	136	24	infection	infection	NN
cord-336510-qzm9wgde	136	25	of	of	IN
cord-336510-qzm9wgde	136	26	the	the	DT
cord-336510-qzm9wgde	136	27	newborn	newborn	JJ
cord-336510-qzm9wgde	136	28	[	[	-LRB-
cord-336510-qzm9wgde	136	29	109	109	CD
cord-336510-qzm9wgde	136	30	,	,	,
cord-336510-qzm9wgde	136	31	117	117	CD
cord-336510-qzm9wgde	136	32	]	]	-RRB-
cord-336510-qzm9wgde	136	33	.	.	.
cord-336510-qzm9wgde	137	1	Genital	genital	JJ
cord-336510-qzm9wgde	137	2	HSV	HSV	NNP
cord-336510-qzm9wgde	137	3	reactivations	reactivation	NNS
cord-336510-qzm9wgde	137	4	at	at	IN
cord-336510-qzm9wgde	137	5	labour	labour	NN
cord-336510-qzm9wgde	137	6	only	only	RB
cord-336510-qzm9wgde	137	7	seem	seem	VBP
cord-336510-qzm9wgde	137	8	to	to	TO
cord-336510-qzm9wgde	137	9	posses	posses	VB
cord-336510-qzm9wgde	137	10	a	a	DT
cord-336510-qzm9wgde	137	11	minor	minor	JJ
cord-336510-qzm9wgde	137	12	risk	risk	NN
cord-336510-qzm9wgde	137	13	for	for	IN
cord-336510-qzm9wgde	137	14	neonatal	neonatal	JJ
cord-336510-qzm9wgde	137	15	infection	infection	NN
cord-336510-qzm9wgde	137	16	of	of	IN
cord-336510-qzm9wgde	137	17	the	the	DT
cord-336510-qzm9wgde	137	18	baby	baby	NN
cord-336510-qzm9wgde	137	19	[	[	-LRB-
cord-336510-qzm9wgde	137	20	117	117	CD
cord-336510-qzm9wgde	137	21	,	,	,
cord-336510-qzm9wgde	137	22	118	118	CD
cord-336510-qzm9wgde	137	23	]	]	-RRB-
cord-336510-qzm9wgde	137	24	,	,	,
cord-336510-qzm9wgde	137	25	but	but	CC
cord-336510-qzm9wgde	137	26	in	in	IN
cord-336510-qzm9wgde	137	27	spite	spite	NN
cord-336510-qzm9wgde	137	28	of	of	IN
cord-336510-qzm9wgde	137	29	this	this	DT
cord-336510-qzm9wgde	137	30	,	,	,
cord-336510-qzm9wgde	137	31	approximately	approximately	RB
cord-336510-qzm9wgde	137	32	70	70	CD
cord-336510-qzm9wgde	137	33	%	%	NN
cord-336510-qzm9wgde	137	34	of	of	IN
cord-336510-qzm9wgde	137	35	neonates	neonate	NNS
cord-336510-qzm9wgde	137	36	infected	infect	VBN
cord-336510-qzm9wgde	137	37	are	be	VBP
cord-336510-qzm9wgde	137	38	born	bear	VBN
cord-336510-qzm9wgde	137	39	by	by	IN
cord-336510-qzm9wgde	137	40	asymptomatic	asymptomatic	JJ
cord-336510-qzm9wgde	137	41	women	woman	NNS
cord-336510-qzm9wgde	137	42	[	[	-LRB-
cord-336510-qzm9wgde	137	43	63	63	CD
cord-336510-qzm9wgde	137	44	]	]	-RRB-
cord-336510-qzm9wgde	137	45	.	.	.
cord-336510-qzm9wgde	138	1	The	the	DT
cord-336510-qzm9wgde	138	2	amount	amount	NN
cord-336510-qzm9wgde	138	3	of	of	IN
cord-336510-qzm9wgde	138	4	virus	virus	NN
cord-336510-qzm9wgde	138	5	in	in	IN
cord-336510-qzm9wgde	138	6	vaginal	vaginal	JJ
cord-336510-qzm9wgde	138	7	secretions	secretion	NNS
cord-336510-qzm9wgde	138	8	during	during	IN
cord-336510-qzm9wgde	138	9	reactivations	reactivation	NNS
cord-336510-qzm9wgde	138	10	is	be	VBZ
cord-336510-qzm9wgde	138	11	much	much	RB
cord-336510-qzm9wgde	138	12	lower	low	JJR
cord-336510-qzm9wgde	138	13	than	than	IN
cord-336510-qzm9wgde	138	14	the	the	DT
cord-336510-qzm9wgde	138	15	amount	amount	NN
cord-336510-qzm9wgde	138	16	of	of	IN
cord-336510-qzm9wgde	138	17	virus	virus	NN
cord-336510-qzm9wgde	138	18	in	in	IN
cord-336510-qzm9wgde	138	19	primary	primary	JJ
cord-336510-qzm9wgde	138	20	infections	infection	NNS
cord-336510-qzm9wgde	138	21	,	,	,
cord-336510-qzm9wgde	138	22	and	and	CC
cord-336510-qzm9wgde	138	23	in	in	IN
cord-336510-qzm9wgde	138	24	reactivated	reactivate	VBN
cord-336510-qzm9wgde	138	25	cases	case	NNS
cord-336510-qzm9wgde	138	26	maternal	maternal	JJ
cord-336510-qzm9wgde	138	27	antibodies	antibody	NNS
cord-336510-qzm9wgde	138	28	furthermore	furthermore	RB
cord-336510-qzm9wgde	138	29	seems	seem	VBZ
cord-336510-qzm9wgde	138	30	to	to	TO
cord-336510-qzm9wgde	138	31	be	be	VB
cord-336510-qzm9wgde	138	32	protective	protective	JJ
cord-336510-qzm9wgde	138	33	for	for	IN
cord-336510-qzm9wgde	138	34	the	the	DT
cord-336510-qzm9wgde	138	35	neonate	neonate	NN
cord-336510-qzm9wgde	138	36	[	[	-LRB-
cord-336510-qzm9wgde	138	37	117	117	CD
cord-336510-qzm9wgde	138	38	,	,	,
cord-336510-qzm9wgde	138	39	[	[	-LRB-
cord-336510-qzm9wgde	138	40	119	119	CD
cord-336510-qzm9wgde	138	41	]	]	-RRB-
cord-336510-qzm9wgde	138	42	[	[	-LRB-
cord-336510-qzm9wgde	138	43	120	120	CD
cord-336510-qzm9wgde	138	44	]	]	-RRB-
cord-336510-qzm9wgde	138	45	[	[	-LRB-
cord-336510-qzm9wgde	138	46	121	121	CD
cord-336510-qzm9wgde	138	47	]	]	-RRB-
cord-336510-qzm9wgde	138	48	[	[	-LRB-
cord-336510-qzm9wgde	138	49	122	122	CD
cord-336510-qzm9wgde	138	50	]	]	-RRB-
cord-336510-qzm9wgde	138	51	.	.	.
cord-336510-qzm9wgde	139	1	When	when	WRB
cord-336510-qzm9wgde	139	2	transmitted	transmit	VBN
cord-336510-qzm9wgde	139	3	,	,	,
cord-336510-qzm9wgde	139	4	the	the	DT
cord-336510-qzm9wgde	139	5	course	course	NN
cord-336510-qzm9wgde	139	6	of	of	IN
cord-336510-qzm9wgde	139	7	HSV	HSV	NNP
cord-336510-qzm9wgde	139	8	infection	infection	NN
cord-336510-qzm9wgde	139	9	in	in	IN
cord-336510-qzm9wgde	139	10	the	the	DT
cord-336510-qzm9wgde	139	11	newborn	newborn	JJ
cord-336510-qzm9wgde	139	12	varies	vary	VBZ
cord-336510-qzm9wgde	139	13	.	.	.
cord-336510-qzm9wgde	140	1	In	in	IN
cord-336510-qzm9wgde	140	2	the	the	DT
cord-336510-qzm9wgde	140	3	pre	pre	JJ
cord-336510-qzm9wgde	140	4	-	-	JJ
cord-336510-qzm9wgde	140	5	acyclovir	acyclovir	JJ
cord-336510-qzm9wgde	140	6	era	era	NN
cord-336510-qzm9wgde	140	7	about	about	RB
cord-336510-qzm9wgde	140	8	one	one	CD
cord-336510-qzm9wgde	140	9	third	third	NN
cord-336510-qzm9wgde	140	10	of	of	IN
cord-336510-qzm9wgde	140	11	cases	case	NNS
cord-336510-qzm9wgde	140	12	were	be	VBD
cord-336510-qzm9wgde	140	13	mucocutaneus	mucocutaneus	NN
cord-336510-qzm9wgde	140	14	infections	infection	NNS
cord-336510-qzm9wgde	140	15	only	only	RB
cord-336510-qzm9wgde	140	16	involving	involve	VBG
cord-336510-qzm9wgde	140	17	the	the	DT
cord-336510-qzm9wgde	140	18	skin	skin	NN
cord-336510-qzm9wgde	140	19	,	,	,
cord-336510-qzm9wgde	140	20	mouth	mouth	NN
cord-336510-qzm9wgde	140	21	and	and	CC
cord-336510-qzm9wgde	140	22	eyes	eye	NNS
cord-336510-qzm9wgde	140	23	,	,	,
cord-336510-qzm9wgde	140	24	one	one	CD
cord-336510-qzm9wgde	140	25	third	third	JJ
cord-336510-qzm9wgde	140	26	were	be	VBD
cord-336510-qzm9wgde	140	27	infections	infection	NNS
cord-336510-qzm9wgde	140	28	of	of	IN
cord-336510-qzm9wgde	140	29	the	the	DT
cord-336510-qzm9wgde	140	30	central	central	JJ
cord-336510-qzm9wgde	140	31	nervous	nervous	JJ
cord-336510-qzm9wgde	140	32	system	system	NN
cord-336510-qzm9wgde	140	33	(	(	-LRB-
cord-336510-qzm9wgde	140	34	CNS	CNS	NNP
cord-336510-qzm9wgde	140	35	)	)	-RRB-
cord-336510-qzm9wgde	140	36	with	with	IN
cord-336510-qzm9wgde	140	37	or	or	CC
cord-336510-qzm9wgde	140	38	without	without	IN
cord-336510-qzm9wgde	140	39	mucocutaneus	mucocutaneus	NNP
cord-336510-qzm9wgde	140	40	involvement	involvement	NN
cord-336510-qzm9wgde	140	41	,	,	,
cord-336510-qzm9wgde	140	42	and	and	CC
cord-336510-qzm9wgde	140	43	the	the	DT
cord-336510-qzm9wgde	140	44	last	last	JJ
cord-336510-qzm9wgde	140	45	third	third	NN
cord-336510-qzm9wgde	140	46	were	be	VBD
cord-336510-qzm9wgde	140	47	disseminated	disseminate	VBN
cord-336510-qzm9wgde	140	48	infections	infection	NNS
cord-336510-qzm9wgde	140	49	involving	involve	VBG
cord-336510-qzm9wgde	140	50	multiple	multiple	JJ
cord-336510-qzm9wgde	140	51	organs	organ	NNS
cord-336510-qzm9wgde	140	52	,	,	,
cord-336510-qzm9wgde	140	53	including	include	VBG
cord-336510-qzm9wgde	140	54	the	the	DT
cord-336510-qzm9wgde	140	55	liver	liver	NN
cord-336510-qzm9wgde	140	56	,	,	,
cord-336510-qzm9wgde	140	57	lungs	lung	NNS
cord-336510-qzm9wgde	140	58	,	,	,
cord-336510-qzm9wgde	140	59	adrenals	adrenal	NNS
cord-336510-qzm9wgde	140	60	,	,	,
cord-336510-qzm9wgde	140	61	and	and	CC
cord-336510-qzm9wgde	140	62	often	often	RB
cord-336510-qzm9wgde	140	63	the	the	DT
cord-336510-qzm9wgde	140	64	CNS	CNS	NNP
cord-336510-qzm9wgde	140	65	[	[	-LRB-
cord-336510-qzm9wgde	140	66	119	119	CD
cord-336510-qzm9wgde	140	67	]	]	-RRB-
cord-336510-qzm9wgde	140	68	.	.	.
cord-336510-qzm9wgde	141	1	Of	of	IN
cord-336510-qzm9wgde	141	2	these	these	DT
cord-336510-qzm9wgde	141	3	,	,	,
cord-336510-qzm9wgde	141	4	neonates	neonate	NNS
cord-336510-qzm9wgde	141	5	with	with	IN
cord-336510-qzm9wgde	141	6	a	a	DT
cord-336510-qzm9wgde	141	7	generalized	generalized	JJ
cord-336510-qzm9wgde	141	8	infection	infection	NN
cord-336510-qzm9wgde	141	9	had	have	VBD
cord-336510-qzm9wgde	141	10	a	a	DT
cord-336510-qzm9wgde	141	11	one	one	CD
cord-336510-qzm9wgde	141	12	-	-	HYPH
cord-336510-qzm9wgde	141	13	year	year	NN
cord-336510-qzm9wgde	141	14	mortality	mortality	NN
cord-336510-qzm9wgde	141	15	of	of	IN
cord-336510-qzm9wgde	141	16	approximately	approximately	RB
cord-336510-qzm9wgde	141	17	60	60	CD
cord-336510-qzm9wgde	141	18	%	%	NN
cord-336510-qzm9wgde	141	19	,	,	,
cord-336510-qzm9wgde	141	20	those	those	DT
cord-336510-qzm9wgde	141	21	with	with	IN
cord-336510-qzm9wgde	141	22	CNS	CNS	NNP
cord-336510-qzm9wgde	141	23	-	-	HYPH
cord-336510-qzm9wgde	141	24	infections	infection	NNS
cord-336510-qzm9wgde	141	25	had	have	VBD
cord-336510-qzm9wgde	141	26	intermediary	intermediary	JJ
cord-336510-qzm9wgde	141	27	mortality	mortality	NN
cord-336510-qzm9wgde	141	28	,	,	,
cord-336510-qzm9wgde	141	29	and	and	CC
cord-336510-qzm9wgde	141	30	nearly	nearly	RB
cord-336510-qzm9wgde	141	31	no	no	DT
cord-336510-qzm9wgde	141	32	mortality	mortality	NN
cord-336510-qzm9wgde	141	33	was	be	VBD
cord-336510-qzm9wgde	141	34	seen	see	VBN
cord-336510-qzm9wgde	141	35	in	in	IN
cord-336510-qzm9wgde	141	36	the	the	DT
cord-336510-qzm9wgde	141	37	group	group	NN
cord-336510-qzm9wgde	141	38	of	of	IN
cord-336510-qzm9wgde	141	39	patients	patient	NNS
cord-336510-qzm9wgde	141	40	with	with	IN
cord-336510-qzm9wgde	141	41	only	only	JJ
cord-336510-qzm9wgde	141	42	mucocutaneus	mucocutaneus	NN
cord-336510-qzm9wgde	141	43	involvement	involvement	NN
cord-336510-qzm9wgde	141	44	[	[	-LRB-
cord-336510-qzm9wgde	141	45	119	119	CD
cord-336510-qzm9wgde	141	46	]	]	-RRB-
cord-336510-qzm9wgde	141	47	.	.	.
cord-336510-qzm9wgde	142	1	In	in	IN
cord-336510-qzm9wgde	142	2	infected	infect	VBN
cord-336510-qzm9wgde	142	3	with	with	IN
cord-336510-qzm9wgde	142	4	multi	multi	JJ
cord-336510-qzm9wgde	142	5	-	-	JJ
cord-336510-qzm9wgde	142	6	organ	organ	JJ
cord-336510-qzm9wgde	142	7	involvement	involvement	NN
cord-336510-qzm9wgde	142	8	the	the	DT
cord-336510-qzm9wgde	142	9	deaths	death	NNS
cord-336510-qzm9wgde	142	10	are	be	VBP
cord-336510-qzm9wgde	142	11	often	often	RB
cord-336510-qzm9wgde	142	12	set	set	VBN
cord-336510-qzm9wgde	142	13	off	off	RP
cord-336510-qzm9wgde	142	14	by	by	IN
cord-336510-qzm9wgde	142	15	infection	infection	NN
cord-336510-qzm9wgde	142	16	of	of	IN
cord-336510-qzm9wgde	142	17	liver	liver	NN
cord-336510-qzm9wgde	142	18	or	or	CC
cord-336510-qzm9wgde	142	19	lungs	lung	NNS
cord-336510-qzm9wgde	142	20	or	or	CC
cord-336510-qzm9wgde	142	21	by	by	IN
cord-336510-qzm9wgde	142	22	coagulopathy	coagulopathy	NN
cord-336510-qzm9wgde	142	23	.	.	.
cord-336510-qzm9wgde	143	1	Sequelae	sequela	NNS
cord-336510-qzm9wgde	143	2	,	,	,
cord-336510-qzm9wgde	143	3	such	such	JJ
cord-336510-qzm9wgde	143	4	as	as	IN
cord-336510-qzm9wgde	143	5	mental	mental	JJ
cord-336510-qzm9wgde	143	6	or	or	CC
cord-336510-qzm9wgde	143	7	neurological	neurological	JJ
cord-336510-qzm9wgde	143	8	disabilities	disability	NNS
cord-336510-qzm9wgde	143	9	are	be	VBP
cord-336510-qzm9wgde	143	10	seen	see	VBN
cord-336510-qzm9wgde	143	11	in	in	IN
cord-336510-qzm9wgde	143	12	some	some	DT
cord-336510-qzm9wgde	143	13	of	of	IN
cord-336510-qzm9wgde	143	14	those	those	DT
cord-336510-qzm9wgde	143	15	with	with	IN
cord-336510-qzm9wgde	143	16	CNS	CNS	NNP
cord-336510-qzm9wgde	143	17	involvement	involvement	NN
cord-336510-qzm9wgde	143	18	[	[	-LRB-
cord-336510-qzm9wgde	143	19	123	123	CD
cord-336510-qzm9wgde	143	20	]	]	-RRB-
cord-336510-qzm9wgde	143	21	.	.	.
cord-336510-qzm9wgde	144	1	Now	now	RB
cord-336510-qzm9wgde	144	2	a	a	DT
cord-336510-qzm9wgde	144	3	day	day	NN
cord-336510-qzm9wgde	144	4	,	,	,
cord-336510-qzm9wgde	144	5	after	after	IN
cord-336510-qzm9wgde	144	6	initiation	initiation	NN
cord-336510-qzm9wgde	144	7	of	of	IN
cord-336510-qzm9wgde	144	8	high	high	JJ
cord-336510-qzm9wgde	144	9	-	-	HYPH
cord-336510-qzm9wgde	144	10	dose	dose	NN
cord-336510-qzm9wgde	144	11	acyclovir	acyclovir	NNP
cord-336510-qzm9wgde	144	12	treatment	treatment	NN
cord-336510-qzm9wgde	144	13	,	,	,
cord-336510-qzm9wgde	144	14	the	the	DT
cord-336510-qzm9wgde	144	15	mortality	mortality	NN
cord-336510-qzm9wgde	144	16	and	and	CC
cord-336510-qzm9wgde	144	17	sequela	sequela	NN
cord-336510-qzm9wgde	144	18	rates	rate	NNS
cord-336510-qzm9wgde	144	19	have	have	VBP
cord-336510-qzm9wgde	144	20	dropped	drop	VBN
cord-336510-qzm9wgde	144	21	[	[	-LRB-
cord-336510-qzm9wgde	144	22	124	124	CD
cord-336510-qzm9wgde	144	23	]	]	-RRB-
cord-336510-qzm9wgde	144	24	.	.	.
cord-336510-qzm9wgde	145	1	The	the	DT
cord-336510-qzm9wgde	145	2	clinical	clinical	JJ
cord-336510-qzm9wgde	145	3	pattern	pattern	NN
cord-336510-qzm9wgde	145	4	of	of	IN
cord-336510-qzm9wgde	145	5	neonatal	neonatal	JJ
cord-336510-qzm9wgde	145	6	HSV	HSV	NNP
cord-336510-qzm9wgde	145	7	infections	infection	NNS
cord-336510-qzm9wgde	145	8	has	have	VBZ
cord-336510-qzm9wgde	145	9	changed	change	VBN
cord-336510-qzm9wgde	145	10	in	in	IN
cord-336510-qzm9wgde	145	11	that	that	DT
cord-336510-qzm9wgde	145	12	less	less	JJR
cord-336510-qzm9wgde	145	13	of	of	IN
cord-336510-qzm9wgde	145	14	the	the	DT
cord-336510-qzm9wgde	145	15	mucocutaneus	mucocutaneus	NNP
cord-336510-qzm9wgde	145	16	infections	infection	NNS
cord-336510-qzm9wgde	145	17	disseminate	disseminate	VBP
cord-336510-qzm9wgde	145	18	to	to	IN
cord-336510-qzm9wgde	145	19	generalized	generalized	JJ
cord-336510-qzm9wgde	145	20	infections	infection	NNS
cord-336510-qzm9wgde	145	21	when	when	WRB
cord-336510-qzm9wgde	145	22	treated	treat	VBN
cord-336510-qzm9wgde	145	23	[	[	-LRB-
cord-336510-qzm9wgde	145	24	123	123	CD
cord-336510-qzm9wgde	145	25	]	]	-RRB-
cord-336510-qzm9wgde	145	26	.	.	.
cord-336510-qzm9wgde	146	1	Even	even	RB
cord-336510-qzm9wgde	146	2	with	with	IN
cord-336510-qzm9wgde	146	3	high	high	JJ
cord-336510-qzm9wgde	146	4	-	-	HYPH
cord-336510-qzm9wgde	146	5	dose	dose	NN
cord-336510-qzm9wgde	146	6	acyclovir	acyclovir	NN
cord-336510-qzm9wgde	146	7	,	,	,
cord-336510-qzm9wgde	146	8	improvements	improvement	NNS
cord-336510-qzm9wgde	146	9	in	in	IN
cord-336510-qzm9wgde	146	10	treatment	treatment	NN
cord-336510-qzm9wgde	146	11	protocols	protocol	NNS
cord-336510-qzm9wgde	146	12	are	be	VBP
cord-336510-qzm9wgde	146	13	still	still	RB
cord-336510-qzm9wgde	146	14	needed	need	VBN
cord-336510-qzm9wgde	146	15	,	,	,
cord-336510-qzm9wgde	146	16	because	because	IN
cord-336510-qzm9wgde	146	17	the	the	DT
cord-336510-qzm9wgde	146	18	mortality	mortality	NN
cord-336510-qzm9wgde	146	19	is	be	VBZ
cord-336510-qzm9wgde	146	20	still	still	RB
cord-336510-qzm9wgde	146	21	as	as	RB
cord-336510-qzm9wgde	146	22	high	high	JJ
cord-336510-qzm9wgde	146	23	as	as	IN
cord-336510-qzm9wgde	146	24	30	30	CD
cord-336510-qzm9wgde	146	25	%	%	NN
cord-336510-qzm9wgde	146	26	in	in	IN
cord-336510-qzm9wgde	146	27	disseminated	disseminate	VBN
cord-336510-qzm9wgde	146	28	infections	infection	NNS
cord-336510-qzm9wgde	146	29	.	.	.
cord-336510-qzm9wgde	147	1	Reduction	reduction	NN
cord-336510-qzm9wgde	147	2	in	in	IN
cord-336510-qzm9wgde	147	3	the	the	DT
cord-336510-qzm9wgde	147	4	time	time	NN
cord-336510-qzm9wgde	147	5	from	from	IN
cord-336510-qzm9wgde	147	6	debut	debut	NN
cord-336510-qzm9wgde	147	7	of	of	IN
cord-336510-qzm9wgde	147	8	symptoms	symptom	NNS
cord-336510-qzm9wgde	147	9	to	to	IN
cord-336510-qzm9wgde	147	10	initiation	initiation	NN
cord-336510-qzm9wgde	147	11	of	of	IN
cord-336510-qzm9wgde	147	12	therapy	therapy	NN
cord-336510-qzm9wgde	147	13	is	be	VBZ
cord-336510-qzm9wgde	147	14	vital	vital	JJ
cord-336510-qzm9wgde	147	15	and	and	CC
cord-336510-qzm9wgde	147	16	passive	passive	JJ
cord-336510-qzm9wgde	147	17	immunotherapy	immunotherapy	NN
cord-336510-qzm9wgde	147	18	with	with	IN
cord-336510-qzm9wgde	147	19	HSV	HSV	NNP
cord-336510-qzm9wgde	147	20	-	-	HYPH
cord-336510-qzm9wgde	147	21	specific	specific	JJ
cord-336510-qzm9wgde	147	22	antibodies	antibody	NNS
cord-336510-qzm9wgde	147	23	could	could	MD
cord-336510-qzm9wgde	147	24	posses	posse	VBZ
cord-336510-qzm9wgde	147	25	a	a	DT
cord-336510-qzm9wgde	147	26	potential	potential	NN
cord-336510-qzm9wgde	147	27	as	as	IN
cord-336510-qzm9wgde	147	28	adjuvant	adjuvant	JJ
cord-336510-qzm9wgde	147	29	to	to	IN
cord-336510-qzm9wgde	147	30	the	the	DT
cord-336510-qzm9wgde	147	31	antiviral	antiviral	JJ
cord-336510-qzm9wgde	147	32	treatment	treatment	NN
cord-336510-qzm9wgde	147	33	[	[	-LRB-
cord-336510-qzm9wgde	147	34	123	123	CD
cord-336510-qzm9wgde	147	35	,	,	,
cord-336510-qzm9wgde	147	36	125	125	CD
cord-336510-qzm9wgde	147	37	,	,	,
cord-336510-qzm9wgde	147	38	126	126	CD
cord-336510-qzm9wgde	147	39	]	]	-RRB-
cord-336510-qzm9wgde	147	40	.	.	.
cord-336510-qzm9wgde	148	1	Other	other	JJ
cord-336510-qzm9wgde	148	2	adjuvant	adjuvant	JJ
cord-336510-qzm9wgde	148	3	treatment	treatment	NN
cord-336510-qzm9wgde	148	4	modalities	modality	NNS
cord-336510-qzm9wgde	148	5	are	be	VBP
cord-336510-qzm9wgde	148	6	still	still	RB
cord-336510-qzm9wgde	148	7	needed	need	VBN
cord-336510-qzm9wgde	148	8	in	in	IN
cord-336510-qzm9wgde	148	9	both	both	DT
cord-336510-qzm9wgde	148	10	neonatal	neonatal	JJ
cord-336510-qzm9wgde	148	11	infections	infection	NNS
cord-336510-qzm9wgde	148	12	and	and	CC
cord-336510-qzm9wgde	148	13	in	in	IN
cord-336510-qzm9wgde	148	14	generalized	generalized	JJ
cord-336510-qzm9wgde	148	15	infections	infection	NNS
cord-336510-qzm9wgde	148	16	at	at	IN
cord-336510-qzm9wgde	148	17	later	later	JJ
cord-336510-qzm9wgde	148	18	ages	age	NNS
cord-336510-qzm9wgde	148	19	.	.	.
cord-336510-qzm9wgde	149	1	The	the	DT
cord-336510-qzm9wgde	149	2	pathology	pathology	NN
cord-336510-qzm9wgde	149	3	of	of	IN
cord-336510-qzm9wgde	149	4	HSV	HSV	NNP
cord-336510-qzm9wgde	149	5	infections	infection	NNS
cord-336510-qzm9wgde	149	6	is	be	VBZ
cord-336510-qzm9wgde	149	7	mainly	mainly	RB
cord-336510-qzm9wgde	149	8	caused	cause	VBN
cord-336510-qzm9wgde	149	9	by	by	IN
cord-336510-qzm9wgde	149	10	a	a	DT
cord-336510-qzm9wgde	149	11	direct	direct	JJ
cord-336510-qzm9wgde	149	12	cytopathic	cytopathic	JJ
cord-336510-qzm9wgde	149	13	effect	effect	NN
cord-336510-qzm9wgde	149	14	of	of	IN
cord-336510-qzm9wgde	149	15	the	the	DT
cord-336510-qzm9wgde	149	16	virus	virus	NN
cord-336510-qzm9wgde	149	17	,	,	,
cord-336510-qzm9wgde	149	18	resulting	result	VBG
cord-336510-qzm9wgde	149	19	in	in	IN
cord-336510-qzm9wgde	149	20	cellular	cellular	JJ
cord-336510-qzm9wgde	149	21	lysis	lysis	NN
cord-336510-qzm9wgde	149	22	and	and	CC
cord-336510-qzm9wgde	149	23	focal	focal	JJ
cord-336510-qzm9wgde	149	24	necrosis	necrosis	NN
cord-336510-qzm9wgde	149	25	of	of	IN
cord-336510-qzm9wgde	149	26	the	the	DT
cord-336510-qzm9wgde	149	27	infected	infected	JJ
cord-336510-qzm9wgde	149	28	area	area	NN
cord-336510-qzm9wgde	149	29	[	[	-LRB-
cord-336510-qzm9wgde	149	30	119	119	CD
cord-336510-qzm9wgde	149	31	,	,	,
cord-336510-qzm9wgde	149	32	127	127	CD
cord-336510-qzm9wgde	149	33	,	,	,
cord-336510-qzm9wgde	149	34	128	128	CD
cord-336510-qzm9wgde	149	35	]	]	-RRB-
cord-336510-qzm9wgde	149	36	.	.	.
cord-336510-qzm9wgde	150	1	In	in	IN
cord-336510-qzm9wgde	150	2	tissues	tissue	NNS
cord-336510-qzm9wgde	150	3	capable	capable	JJ
cord-336510-qzm9wgde	150	4	of	of	IN
cord-336510-qzm9wgde	150	5	regeneration	regeneration	NN
cord-336510-qzm9wgde	150	6	,	,	,
cord-336510-qzm9wgde	150	7	this	this	DT
cord-336510-qzm9wgde	150	8	is	be	VBZ
cord-336510-qzm9wgde	150	9	not	not	RB
cord-336510-qzm9wgde	150	10	devastating	devastating	JJ
cord-336510-qzm9wgde	150	11	,	,	,
cord-336510-qzm9wgde	150	12	provided	provide	VBN
cord-336510-qzm9wgde	150	13	that	that	IN
cord-336510-qzm9wgde	150	14	the	the	DT
cord-336510-qzm9wgde	150	15	lesions	lesion	NNS
cord-336510-qzm9wgde	150	16	do	do	VBP
cord-336510-qzm9wgde	150	17	not	not	RB
cord-336510-qzm9wgde	150	18	totally	totally	RB
cord-336510-qzm9wgde	150	19	destroy	destroy	VB
cord-336510-qzm9wgde	150	20	the	the	DT
cord-336510-qzm9wgde	150	21	organ	organ	NN
cord-336510-qzm9wgde	150	22	or	or	CC
cord-336510-qzm9wgde	150	23	result	result	VB
cord-336510-qzm9wgde	150	24	in	in	IN
cord-336510-qzm9wgde	150	25	functional	functional	JJ
cord-336510-qzm9wgde	150	26	disability	disability	NN
cord-336510-qzm9wgde	150	27	during	during	IN
cord-336510-qzm9wgde	150	28	the	the	DT
cord-336510-qzm9wgde	150	29	infection	infection	NN
cord-336510-qzm9wgde	150	30	.	.	.
cord-336510-qzm9wgde	151	1	In	in	IN
cord-336510-qzm9wgde	151	2	the	the	DT
cord-336510-qzm9wgde	151	3	brain	brain	NN
cord-336510-qzm9wgde	151	4	,	,	,
cord-336510-qzm9wgde	151	5	however	however	RB
cord-336510-qzm9wgde	151	6	,	,	,
cord-336510-qzm9wgde	151	7	the	the	DT
cord-336510-qzm9wgde	151	8	capacity	capacity	NN
cord-336510-qzm9wgde	151	9	for	for	IN
cord-336510-qzm9wgde	151	10	regeneration	regeneration	NN
cord-336510-qzm9wgde	151	11	is	be	VBZ
cord-336510-qzm9wgde	151	12	small	small	JJ
cord-336510-qzm9wgde	151	13	,	,	,
cord-336510-qzm9wgde	151	14	and	and	CC
cord-336510-qzm9wgde	151	15	larger	large	JJR
cord-336510-qzm9wgde	151	16	necroses	necrose	NNS
cord-336510-qzm9wgde	151	17	induced	induce	VBN
cord-336510-qzm9wgde	151	18	by	by	IN
cord-336510-qzm9wgde	151	19	viral	viral	JJ
cord-336510-qzm9wgde	151	20	infection	infection	NN
cord-336510-qzm9wgde	151	21	will	will	MD
cord-336510-qzm9wgde	151	22	result	result	VB
cord-336510-qzm9wgde	151	23	in	in	IN
cord-336510-qzm9wgde	151	24	life	life	NN
cord-336510-qzm9wgde	151	25	-	-	HYPH
cord-336510-qzm9wgde	151	26	long	long	JJ
cord-336510-qzm9wgde	151	27	sequelae	sequela	NNS
cord-336510-qzm9wgde	151	28	[	[	-LRB-
cord-336510-qzm9wgde	151	29	119	119	CD
cord-336510-qzm9wgde	151	30	,	,	,
cord-336510-qzm9wgde	151	31	123	123	CD
cord-336510-qzm9wgde	151	32	]	]	-RRB-
cord-336510-qzm9wgde	151	33	.	.	.
cord-336510-qzm9wgde	152	1	A	a	DT
cord-336510-qzm9wgde	152	2	delicate	delicate	JJ
cord-336510-qzm9wgde	152	3	balance	balance	NN
cord-336510-qzm9wgde	152	4	exists	exist	VBZ
cord-336510-qzm9wgde	152	5	between	between	IN
cord-336510-qzm9wgde	152	6	the	the	DT
cord-336510-qzm9wgde	152	7	direct	direct	JJ
cord-336510-qzm9wgde	152	8	HSV	HSV	NNP
cord-336510-qzm9wgde	152	9	-	-	HYPH
cord-336510-qzm9wgde	152	10	induced	induce	VBN
cord-336510-qzm9wgde	152	11	pathology	pathology	NN
cord-336510-qzm9wgde	152	12	and	and	CC
cord-336510-qzm9wgde	152	13	the	the	DT
cord-336510-qzm9wgde	152	14	immunopathology	immunopathology	NN
cord-336510-qzm9wgde	152	15	induced	induce	VBN
cord-336510-qzm9wgde	152	16	by	by	IN
cord-336510-qzm9wgde	152	17	immune	immune	JJ
cord-336510-qzm9wgde	152	18	reactions	reaction	NNS
cord-336510-qzm9wgde	152	19	to	to	IN
cord-336510-qzm9wgde	152	20	the	the	DT
cord-336510-qzm9wgde	152	21	virus	virus	NN
cord-336510-qzm9wgde	152	22	and	and	CC
cord-336510-qzm9wgde	152	23	the	the	DT
cord-336510-qzm9wgde	152	24	toxic	toxic	JJ
cord-336510-qzm9wgde	152	25	and	and	CC
cord-336510-qzm9wgde	152	26	functional	functional	JJ
cord-336510-qzm9wgde	152	27	side	side	NN
cord-336510-qzm9wgde	152	28	effects	effect	NNS
cord-336510-qzm9wgde	152	29	of	of	IN
cord-336510-qzm9wgde	152	30	these	these	DT
cord-336510-qzm9wgde	152	31	reactions	reaction	NNS
cord-336510-qzm9wgde	152	32	[	[	-LRB-
cord-336510-qzm9wgde	152	33	129	129	CD
cord-336510-qzm9wgde	152	34	]	]	-RRB-
cord-336510-qzm9wgde	152	35	.	.	.
cord-336510-qzm9wgde	153	1	Immunopathogenesis	Immunopathogenesis	NNP
cord-336510-qzm9wgde	153	2	seems	seem	VBZ
cord-336510-qzm9wgde	153	3	to	to	TO
cord-336510-qzm9wgde	153	4	be	be	VB
cord-336510-qzm9wgde	153	5	the	the	DT
cord-336510-qzm9wgde	153	6	main	main	JJ
cord-336510-qzm9wgde	153	7	aspect	aspect	NN
cord-336510-qzm9wgde	153	8	of	of	IN
cord-336510-qzm9wgde	153	9	HSV	HSV	NNP
cord-336510-qzm9wgde	153	10	stromal	stromal	NN
cord-336510-qzm9wgde	153	11	keratitis	keratitis	NN
cord-336510-qzm9wgde	153	12	,	,	,
cord-336510-qzm9wgde	153	13	which	which	WDT
cord-336510-qzm9wgde	153	14	often	often	RB
cord-336510-qzm9wgde	153	15	leads	lead	VBZ
cord-336510-qzm9wgde	153	16	to	to	IN
cord-336510-qzm9wgde	153	17	blindness	blindness	NN
cord-336510-qzm9wgde	153	18	[	[	-LRB-
cord-336510-qzm9wgde	153	19	130	130	CD
cord-336510-qzm9wgde	153	20	,	,	,
cord-336510-qzm9wgde	153	21	131	131	CD
cord-336510-qzm9wgde	153	22	]	]	-RRB-
cord-336510-qzm9wgde	153	23	.	.	.
cord-336510-qzm9wgde	154	1	The	the	DT
cord-336510-qzm9wgde	154	2	scarification	scarification	NN
cord-336510-qzm9wgde	154	3	from	from	IN
cord-336510-qzm9wgde	154	4	this	this	DT
cord-336510-qzm9wgde	154	5	infection	infection	NN
cord-336510-qzm9wgde	154	6	has	have	VBZ
cord-336510-qzm9wgde	154	7	even	even	RB
cord-336510-qzm9wgde	154	8	been	be	VBN
cord-336510-qzm9wgde	154	9	attributed	attribute	VBN
cord-336510-qzm9wgde	154	10	to	to	IN
cord-336510-qzm9wgde	154	11	autoimmunity	autoimmunity	NN
cord-336510-qzm9wgde	154	12	by	by	IN
cord-336510-qzm9wgde	154	13	molecular	molecular	JJ
cord-336510-qzm9wgde	154	14	mimicry	mimicry	NN
cord-336510-qzm9wgde	154	15	[	[	-LRB-
cord-336510-qzm9wgde	154	16	132	132	CD
cord-336510-qzm9wgde	154	17	]	]	-RRB-
cord-336510-qzm9wgde	154	18	.	.	.
cord-336510-qzm9wgde	155	1	Weak	weak	JJ
cord-336510-qzm9wgde	155	2	immune	immune	JJ
cord-336510-qzm9wgde	155	3	response	response	NN
cord-336510-qzm9wgde	155	4	to	to	IN
cord-336510-qzm9wgde	155	5	the	the	DT
cord-336510-qzm9wgde	155	6	virus	virus	NN
cord-336510-qzm9wgde	155	7	leads	lead	VBZ
cord-336510-qzm9wgde	155	8	to	to	IN
cord-336510-qzm9wgde	155	9	severe	severe	JJ
cord-336510-qzm9wgde	155	10	infections	infection	NNS
cord-336510-qzm9wgde	155	11	because	because	IN
cord-336510-qzm9wgde	155	12	of	of	IN
cord-336510-qzm9wgde	155	13	massive	massive	JJ
cord-336510-qzm9wgde	155	14	viral	viral	JJ
cord-336510-qzm9wgde	155	15	replication	replication	NN
cord-336510-qzm9wgde	155	16	and	and	CC
cord-336510-qzm9wgde	155	17	dissemination	dissemination	NN
cord-336510-qzm9wgde	155	18	.	.	.
cord-336510-qzm9wgde	156	1	An	an	DT
cord-336510-qzm9wgde	156	2	immense	immense	JJ
cord-336510-qzm9wgde	156	3	immune	immune	JJ
cord-336510-qzm9wgde	156	4	reaction	reaction	NN
cord-336510-qzm9wgde	156	5	,	,	,
cord-336510-qzm9wgde	156	6	especially	especially	RB
cord-336510-qzm9wgde	156	7	with	with	IN
cord-336510-qzm9wgde	156	8	high	high	JJ
cord-336510-qzm9wgde	156	9	amounts	amount	NNS
cord-336510-qzm9wgde	156	10	of	of	IN
cord-336510-qzm9wgde	156	11	virus	virus	NN
cord-336510-qzm9wgde	156	12	to	to	TO
cord-336510-qzm9wgde	156	13	trigger	trigger	VB
cord-336510-qzm9wgde	156	14	a	a	DT
cord-336510-qzm9wgde	156	15	response	response	NN
cord-336510-qzm9wgde	156	16	,	,	,
cord-336510-qzm9wgde	156	17	can	can	MD
cord-336510-qzm9wgde	156	18	bring	bring	VB
cord-336510-qzm9wgde	156	19	about	about	RB
cord-336510-qzm9wgde	156	20	increased	increase	VBN
cord-336510-qzm9wgde	156	21	symptoms	symptom	NNS
cord-336510-qzm9wgde	156	22	of	of	IN
cord-336510-qzm9wgde	156	23	infection	infection	NN
cord-336510-qzm9wgde	156	24	,	,	,
cord-336510-qzm9wgde	156	25	local	local	JJ
cord-336510-qzm9wgde	156	26	symptoms	symptom	NNS
cord-336510-qzm9wgde	156	27	such	such	JJ
cord-336510-qzm9wgde	156	28	as	as	IN
cord-336510-qzm9wgde	156	29	high	high	JJ
cord-336510-qzm9wgde	156	30	intra	intra	JJ
cord-336510-qzm9wgde	156	31	-	-	JJ
cord-336510-qzm9wgde	156	32	cerebral	cerebral	JJ
cord-336510-qzm9wgde	156	33	pressure	pressure	NN
cord-336510-qzm9wgde	156	34	or	or	CC
cord-336510-qzm9wgde	156	35	pulmonary	pulmonary	JJ
cord-336510-qzm9wgde	156	36	complications	complication	NNS
cord-336510-qzm9wgde	156	37	,	,	,
cord-336510-qzm9wgde	156	38	as	as	RB
cord-336510-qzm9wgde	156	39	well	well	RB
cord-336510-qzm9wgde	156	40	as	as	IN
cord-336510-qzm9wgde	156	41	generalized	generalized	JJ
cord-336510-qzm9wgde	156	42	or	or	CC
cord-336510-qzm9wgde	156	43	septic	septic	JJ
cord-336510-qzm9wgde	156	44	symptoms	symptom	NNS
cord-336510-qzm9wgde	156	45	[	[	-LRB-
cord-336510-qzm9wgde	156	46	129	129	CD
cord-336510-qzm9wgde	156	47	,	,	,
cord-336510-qzm9wgde	156	48	[	[	-LRB-
cord-336510-qzm9wgde	156	49	133	133	CD
cord-336510-qzm9wgde	156	50	]	]	-RRB-
cord-336510-qzm9wgde	156	51	[	[	-LRB-
cord-336510-qzm9wgde	156	52	134	134	CD
cord-336510-qzm9wgde	156	53	]	]	-RRB-
cord-336510-qzm9wgde	156	54	[	[	-LRB-
cord-336510-qzm9wgde	156	55	135	135	CD
cord-336510-qzm9wgde	156	56	]	]	-RRB-
cord-336510-qzm9wgde	156	57	[	[	-LRB-
cord-336510-qzm9wgde	156	58	136	136	CD
cord-336510-qzm9wgde	156	59	]	]	-RRB-
cord-336510-qzm9wgde	156	60	.	.	.
cord-336510-qzm9wgde	157	1	It	-PRON-	PRP
cord-336510-qzm9wgde	157	2	is	be	VBZ
cord-336510-qzm9wgde	157	3	thus	thus	RB
cord-336510-qzm9wgde	157	4	clear	clear	JJ
cord-336510-qzm9wgde	157	5	that	that	IN
cord-336510-qzm9wgde	157	6	early	early	JJ
cord-336510-qzm9wgde	157	7	control	control	NN
cord-336510-qzm9wgde	157	8	of	of	IN
cord-336510-qzm9wgde	157	9	HSV	HSV	NNP
cord-336510-qzm9wgde	157	10	replication	replication	NN
cord-336510-qzm9wgde	157	11	in	in	IN
cord-336510-qzm9wgde	157	12	the	the	DT
cord-336510-qzm9wgde	157	13	initial	initial	JJ
cord-336510-qzm9wgde	157	14	phases	phase	NNS
cord-336510-qzm9wgde	157	15	of	of	IN
cord-336510-qzm9wgde	157	16	infection	infection	NN
cord-336510-qzm9wgde	157	17	is	be	VBZ
cord-336510-qzm9wgde	157	18	crucial	crucial	JJ
cord-336510-qzm9wgde	157	19	for	for	IN
cord-336510-qzm9wgde	157	20	the	the	DT
cord-336510-qzm9wgde	157	21	host	host	NN
cord-336510-qzm9wgde	157	22	.	.	.
cord-336510-qzm9wgde	158	1	Early	early	JJ
cord-336510-qzm9wgde	158	2	containment	containment	NN
cord-336510-qzm9wgde	158	3	or	or	CC
cord-336510-qzm9wgde	158	4	at	at	IN
cord-336510-qzm9wgde	158	5	least	least	JJS
cord-336510-qzm9wgde	158	6	inhibition	inhibition	NN
cord-336510-qzm9wgde	158	7	of	of	IN
cord-336510-qzm9wgde	158	8	viral	viral	JJ
cord-336510-qzm9wgde	158	9	replication	replication	NN
cord-336510-qzm9wgde	158	10	can	can	MD
cord-336510-qzm9wgde	158	11	prevent	prevent	VB
cord-336510-qzm9wgde	158	12	dissemination	dissemination	NN
cord-336510-qzm9wgde	158	13	of	of	IN
cord-336510-qzm9wgde	158	14	the	the	DT
cord-336510-qzm9wgde	158	15	infection	infection	NN
cord-336510-qzm9wgde	158	16	,	,	,
cord-336510-qzm9wgde	158	17	and	and	CC
cord-336510-qzm9wgde	158	18	the	the	DT
cord-336510-qzm9wgde	158	19	early	early	JJ
cord-336510-qzm9wgde	158	20	nonspecific	nonspecific	JJ
cord-336510-qzm9wgde	158	21	immune	immune	JJ
cord-336510-qzm9wgde	158	22	reactions	reaction	NNS
cord-336510-qzm9wgde	158	23	thus	thus	RB
cord-336510-qzm9wgde	158	24	have	have	VBP
cord-336510-qzm9wgde	158	25	the	the	DT
cord-336510-qzm9wgde	158	26	potential	potential	NN
cord-336510-qzm9wgde	158	27	to	to	TO
cord-336510-qzm9wgde	158	28	inhibit	inhibit	VB
cord-336510-qzm9wgde	158	29	development	development	NN
cord-336510-qzm9wgde	158	30	of	of	IN
cord-336510-qzm9wgde	158	31	a	a	DT
cord-336510-qzm9wgde	158	32	symptomatic	symptomatic	JJ
cord-336510-qzm9wgde	158	33	infection	infection	NN
cord-336510-qzm9wgde	158	34	.	.	.
cord-336510-qzm9wgde	159	1	Obviously	obviously	RB
cord-336510-qzm9wgde	159	2	the	the	DT
cord-336510-qzm9wgde	159	3	host	host	NN
cord-336510-qzm9wgde	159	4	will	will	MD
cord-336510-qzm9wgde	159	5	benefit	benefit	VB
cord-336510-qzm9wgde	159	6	from	from	IN
cord-336510-qzm9wgde	159	7	an	an	DT
cord-336510-qzm9wgde	159	8	attenuated	attenuated	JJ
cord-336510-qzm9wgde	159	9	or	or	CC
cord-336510-qzm9wgde	159	10	asymptomatic	asymptomatic	JJ
cord-336510-qzm9wgde	159	11	course	course	NN
cord-336510-qzm9wgde	159	12	of	of	IN
cord-336510-qzm9wgde	159	13	infection	infection	NN
cord-336510-qzm9wgde	159	14	,	,	,
cord-336510-qzm9wgde	159	15	but	but	CC
cord-336510-qzm9wgde	159	16	HSV	HSV	NNP
cord-336510-qzm9wgde	159	17	-with	-with	.
cord-336510-qzm9wgde	160	1	the	the	DT
cord-336510-qzm9wgde	160	2	potential	potential	NN
cord-336510-qzm9wgde	160	3	of	of	IN
cord-336510-qzm9wgde	160	4	subsequent	subsequent	JJ
cord-336510-qzm9wgde	160	5	reactivation	reactivation	NN
cord-336510-qzm9wgde	160	6	from	from	IN
cord-336510-qzm9wgde	160	7	a	a	DT
cord-336510-qzm9wgde	160	8	latent	latent	JJ
cord-336510-qzm9wgde	160	9	site	site	NN
cord-336510-qzm9wgde	160	10	-could	-could	:
cord-336510-qzm9wgde	160	11	also	also	RB
cord-336510-qzm9wgde	160	12	benefit	benefit	VB
cord-336510-qzm9wgde	160	13	from	from	IN
cord-336510-qzm9wgde	160	14	such	such	PDT
cord-336510-qzm9wgde	160	15	a	a	DT
cord-336510-qzm9wgde	160	16	course	course	NN
cord-336510-qzm9wgde	160	17	of	of	IN
cord-336510-qzm9wgde	160	18	infection	infection	NN
cord-336510-qzm9wgde	160	19	,	,	,
cord-336510-qzm9wgde	160	20	in	in	IN
cord-336510-qzm9wgde	160	21	that	that	IN
cord-336510-qzm9wgde	160	22	the	the	DT
cord-336510-qzm9wgde	160	23	host	host	NN
cord-336510-qzm9wgde	160	24	will	will	MD
cord-336510-qzm9wgde	160	25	survive	survive	VB
cord-336510-qzm9wgde	160	26	and	and	CC
cord-336510-qzm9wgde	160	27	the	the	DT
cord-336510-qzm9wgde	160	28	activity	activity	NN
cord-336510-qzm9wgde	160	29	of	of	IN
cord-336510-qzm9wgde	160	30	the	the	DT
cord-336510-qzm9wgde	160	31	host	host	NN
cord-336510-qzm9wgde	160	32	in	in	IN
cord-336510-qzm9wgde	160	33	society	society	NN
cord-336510-qzm9wgde	160	34	will	will	MD
cord-336510-qzm9wgde	160	35	not	not	RB
cord-336510-qzm9wgde	160	36	be	be	VB
cord-336510-qzm9wgde	160	37	hampered	hamper	VBN
cord-336510-qzm9wgde	160	38	by	by	IN
cord-336510-qzm9wgde	160	39	symptoms	symptom	NNS
cord-336510-qzm9wgde	160	40	from	from	IN
cord-336510-qzm9wgde	160	41	infection	infection	NN
cord-336510-qzm9wgde	160	42	.	.	.
cord-336510-qzm9wgde	161	1	Thus	thus	RB
cord-336510-qzm9wgde	161	2	,	,	,
cord-336510-qzm9wgde	161	3	the	the	DT
cord-336510-qzm9wgde	161	4	HSV	HSV	NNP
cord-336510-qzm9wgde	161	5	has	have	VBZ
cord-336510-qzm9wgde	161	6	excellent	excellent	JJ
cord-336510-qzm9wgde	161	7	chances	chance	NNS
cord-336510-qzm9wgde	161	8	to	to	TO
cord-336510-qzm9wgde	161	9	reach	reach	VB
cord-336510-qzm9wgde	161	10	new	new	JJ
cord-336510-qzm9wgde	161	11	susceptible	susceptible	JJ
cord-336510-qzm9wgde	161	12	hosts	host	NNS
cord-336510-qzm9wgde	161	13	which	which	WDT
cord-336510-qzm9wgde	161	14	bring	bring	VBP
cord-336510-qzm9wgde	161	15	the	the	DT
cord-336510-qzm9wgde	161	16	virus	virus	NN
cord-336510-qzm9wgde	161	17	and	and	CC
cord-336510-qzm9wgde	161	18	the	the	DT
cord-336510-qzm9wgde	161	19	host	host	NN
cord-336510-qzm9wgde	161	20	in	in	IN
cord-336510-qzm9wgde	161	21	a	a	DT
cord-336510-qzm9wgde	161	22	situation	situation	NN
cord-336510-qzm9wgde	161	23	of	of	IN
cord-336510-qzm9wgde	161	24	mutual	mutual	JJ
cord-336510-qzm9wgde	161	25	benefit	benefit	NN
cord-336510-qzm9wgde	161	26	[	[	-LRB-
cord-336510-qzm9wgde	161	27	33	33	CD
cord-336510-qzm9wgde	161	28	]	]	-RRB-
cord-336510-qzm9wgde	161	29	.	.	.
cord-336510-qzm9wgde	162	1	with	with	IN
cord-336510-qzm9wgde	162	2	phagocytic	phagocytic	JJ
cord-336510-qzm9wgde	162	3	activity	activity	NN
cord-336510-qzm9wgde	162	4	.	.	.
cord-336510-qzm9wgde	163	1	In	in	IN
cord-336510-qzm9wgde	163	2	1892	1892	CD
cord-336510-qzm9wgde	163	3	Metchnikoff	Metchnikoff	NNP
cord-336510-qzm9wgde	163	4	named	name	VBD
cord-336510-qzm9wgde	163	5	them	-PRON-	PRP
cord-336510-qzm9wgde	163	6	macrophages	macrophage	NNS
cord-336510-qzm9wgde	163	7	(	(	-LRB-
cord-336510-qzm9wgde	163	8	large	large	JJ
cord-336510-qzm9wgde	163	9	eaters	eater	NNS
cord-336510-qzm9wgde	163	10	)	)	-RRB-
cord-336510-qzm9wgde	163	11	in	in	IN
cord-336510-qzm9wgde	163	12	contrast	contrast	NN
cord-336510-qzm9wgde	163	13	to	to	IN
cord-336510-qzm9wgde	163	14	microphages	microphages	NNP
cord-336510-qzm9wgde	163	15	(	(	-LRB-
cord-336510-qzm9wgde	163	16	the	the	DT
cord-336510-qzm9wgde	163	17	polymorphonuclear	polymorphonuclear	NNP
cord-336510-qzm9wgde	163	18	leukocytes	leukocyte	NNS
cord-336510-qzm9wgde	163	19	)	)	-RRB-
cord-336510-qzm9wgde	163	20	[	[	-LRB-
cord-336510-qzm9wgde	163	21	137	137	CD
cord-336510-qzm9wgde	163	22	]	]	-RRB-
cord-336510-qzm9wgde	163	23	,	,	,
cord-336510-qzm9wgde	163	24	and	and	CC
cord-336510-qzm9wgde	163	25	in	in	IN
cord-336510-qzm9wgde	163	26	1924	1924	CD
cord-336510-qzm9wgde	163	27	Aschoff	Aschoff	NNP
cord-336510-qzm9wgde	163	28	defined	define	VBD
cord-336510-qzm9wgde	163	29	the	the	DT
cord-336510-qzm9wgde	163	30	reticuloendothelial	reticuloendothelial	JJ
cord-336510-qzm9wgde	163	31	system	system	NN
cord-336510-qzm9wgde	163	32	by	by	IN
cord-336510-qzm9wgde	163	33	the	the	DT
cord-336510-qzm9wgde	163	34	criteria	criterion	NNS
cord-336510-qzm9wgde	163	35	of	of	IN
cord-336510-qzm9wgde	163	36	uptake	uptake	NN
cord-336510-qzm9wgde	163	37	of	of	IN
cord-336510-qzm9wgde	163	38	vital	vital	JJ
cord-336510-qzm9wgde	163	39	dye	dye	NN
cord-336510-qzm9wgde	163	40	[	[	-LRB-
cord-336510-qzm9wgde	163	41	138	138	CD
cord-336510-qzm9wgde	163	42	]	]	-RRB-
cord-336510-qzm9wgde	163	43	.	.	.
cord-336510-qzm9wgde	164	1	The	the	DT
cord-336510-qzm9wgde	164	2	macrophages	macrophage	NNS
cord-336510-qzm9wgde	164	3	are	be	VBP
cord-336510-qzm9wgde	164	4	now	now	RB
cord-336510-qzm9wgde	164	5	more	more	RBR
cord-336510-qzm9wgde	164	6	precisely	precisely	RB
cord-336510-qzm9wgde	164	7	defined	define	VBN
cord-336510-qzm9wgde	164	8	as	as	IN
cord-336510-qzm9wgde	164	9	an	an	DT
cord-336510-qzm9wgde	164	10	important	important	JJ
cord-336510-qzm9wgde	164	11	member	member	NN
cord-336510-qzm9wgde	164	12	of	of	IN
cord-336510-qzm9wgde	164	13	the	the	DT
cord-336510-qzm9wgde	164	14	mononuclear	mononuclear	JJ
cord-336510-qzm9wgde	164	15	phagocyte	phagocyte	NNP
cord-336510-qzm9wgde	164	16	system	system	NN
cord-336510-qzm9wgde	164	17	,	,	,
cord-336510-qzm9wgde	164	18	defined	define	VBN
cord-336510-qzm9wgde	164	19	in	in	IN
cord-336510-qzm9wgde	164	20	1969	1969	CD
cord-336510-qzm9wgde	164	21	by	by	IN
cord-336510-qzm9wgde	164	22	van	van	NNP
cord-336510-qzm9wgde	164	23	Furth	Furth	NNP
cord-336510-qzm9wgde	164	24	and	and	CC
cord-336510-qzm9wgde	164	25	colleagues	colleague	NNS
cord-336510-qzm9wgde	164	26	[	[	-LRB-
cord-336510-qzm9wgde	164	27	139	139	CD
cord-336510-qzm9wgde	164	28	]	]	-RRB-
cord-336510-qzm9wgde	164	29	.	.	.
cord-336510-qzm9wgde	165	1	In	in	IN
cord-336510-qzm9wgde	165	2	the	the	DT
cord-336510-qzm9wgde	165	3	tissues	tissue	NNS
cord-336510-qzm9wgde	165	4	they	-PRON-	PRP
cord-336510-qzm9wgde	165	5	constitute	constitute	VBP
cord-336510-qzm9wgde	165	6	a	a	DT
cord-336510-qzm9wgde	165	7	dynamic	dynamic	JJ
cord-336510-qzm9wgde	165	8	pool	pool	NN
cord-336510-qzm9wgde	165	9	of	of	IN
cord-336510-qzm9wgde	165	10	cells	cell	NNS
cord-336510-qzm9wgde	165	11	with	with	IN
cord-336510-qzm9wgde	165	12	many	many	JJ
cord-336510-qzm9wgde	165	13	functional	functional	JJ
cord-336510-qzm9wgde	165	14	capabilities	capability	NNS
cord-336510-qzm9wgde	165	15	,	,	,
cord-336510-qzm9wgde	165	16	among	among	IN
cord-336510-qzm9wgde	165	17	which	which	WDT
cord-336510-qzm9wgde	165	18	the	the	DT
cord-336510-qzm9wgde	165	19	capacity	capacity	NN
cord-336510-qzm9wgde	165	20	of	of	IN
cord-336510-qzm9wgde	165	21	phagocytosis	phagocytosis	NN
cord-336510-qzm9wgde	165	22	,	,	,
cord-336510-qzm9wgde	165	23	microbial	microbial	JJ
cord-336510-qzm9wgde	165	24	killing	killing	NN
cord-336510-qzm9wgde	165	25	,	,	,
cord-336510-qzm9wgde	165	26	motility	motility	NN
cord-336510-qzm9wgde	165	27	,	,	,
cord-336510-qzm9wgde	165	28	and	and	CC
cord-336510-qzm9wgde	165	29	adherence	adherence	NN
cord-336510-qzm9wgde	165	30	to	to	IN
cord-336510-qzm9wgde	165	31	surfaces	surface	NNS
cord-336510-qzm9wgde	165	32	are	be	VBP
cord-336510-qzm9wgde	165	33	classic	classic	JJ
cord-336510-qzm9wgde	165	34	[	[	-LRB-
cord-336510-qzm9wgde	165	35	139	139	CD
cord-336510-qzm9wgde	165	36	]	]	-RRB-
cord-336510-qzm9wgde	165	37	.	.	.
cord-336510-qzm9wgde	166	1	The	the	DT
cord-336510-qzm9wgde	166	2	macrophages	macrophage	NNS
cord-336510-qzm9wgde	166	3	originate	originate	VBP
cord-336510-qzm9wgde	166	4	from	from	IN
cord-336510-qzm9wgde	166	5	the	the	DT
cord-336510-qzm9wgde	166	6	bone	bone	NN
cord-336510-qzm9wgde	166	7	marrow	marrow	NN
cord-336510-qzm9wgde	166	8	,	,	,
cord-336510-qzm9wgde	166	9	where	where	WRB
cord-336510-qzm9wgde	166	10	proliferating	proliferate	VBG
cord-336510-qzm9wgde	166	11	promonocytes	promonocyte	NNS
cord-336510-qzm9wgde	166	12	give	give	VBP
cord-336510-qzm9wgde	166	13	rise	rise	NN
cord-336510-qzm9wgde	166	14	to	to	IN
cord-336510-qzm9wgde	166	15	monocytes	monocyte	NNS
cord-336510-qzm9wgde	166	16	which	which	WDT
cord-336510-qzm9wgde	166	17	enter	enter	VBP
cord-336510-qzm9wgde	166	18	the	the	DT
cord-336510-qzm9wgde	166	19	blood	blood	NN
cord-336510-qzm9wgde	166	20	stream	stream	NN
cord-336510-qzm9wgde	166	21	[	[	-LRB-
cord-336510-qzm9wgde	166	22	140	140	CD
cord-336510-qzm9wgde	166	23	]	]	-RRB-
cord-336510-qzm9wgde	166	24	.	.	.
cord-336510-qzm9wgde	167	1	After	after	IN
cord-336510-qzm9wgde	167	2	a	a	DT
cord-336510-qzm9wgde	167	3	mean	mean	JJ
cord-336510-qzm9wgde	167	4	circulation	circulation	NN
cord-336510-qzm9wgde	167	5	time	time	NN
cord-336510-qzm9wgde	167	6	of	of	IN
cord-336510-qzm9wgde	167	7	approximately	approximately	RB
cord-336510-qzm9wgde	167	8	11/2	11/2	CD
cord-336510-qzm9wgde	167	9	day	day	NN
cord-336510-qzm9wgde	167	10	,	,	,
cord-336510-qzm9wgde	167	11	the	the	DT
cord-336510-qzm9wgde	167	12	blood	blood	NN
cord-336510-qzm9wgde	167	13	monocytes	monocyte	NNS
cord-336510-qzm9wgde	167	14	migrate	migrate	VBP
cord-336510-qzm9wgde	167	15	to	to	IN
cord-336510-qzm9wgde	167	16	the	the	DT
cord-336510-qzm9wgde	167	17	tissues	tissue	NNS
cord-336510-qzm9wgde	167	18	[	[	-LRB-
cord-336510-qzm9wgde	167	19	140	140	CD
cord-336510-qzm9wgde	167	20	]	]	-RRB-
cord-336510-qzm9wgde	167	21	.	.	.
cord-336510-qzm9wgde	168	1	In	in	IN
cord-336510-qzm9wgde	168	2	the	the	DT
cord-336510-qzm9wgde	168	3	tissues	tissue	NNS
cord-336510-qzm9wgde	168	4	the	the	DT
cord-336510-qzm9wgde	168	5	monocytes	monocyte	NNS
cord-336510-qzm9wgde	168	6	differentiate	differentiate	VBP
cord-336510-qzm9wgde	168	7	into	into	IN
cord-336510-qzm9wgde	168	8	macrophages	macrophage	NNS
cord-336510-qzm9wgde	168	9	with	with	IN
cord-336510-qzm9wgde	168	10	characteristics	characteristic	NNS
cord-336510-qzm9wgde	168	11	determined	determine	VBN
cord-336510-qzm9wgde	168	12	by	by	IN
cord-336510-qzm9wgde	168	13	the	the	DT
cord-336510-qzm9wgde	168	14	environment	environment	NN
cord-336510-qzm9wgde	168	15	of	of	IN
cord-336510-qzm9wgde	168	16	the	the	DT
cord-336510-qzm9wgde	168	17	tissue	tissue	NN
cord-336510-qzm9wgde	168	18	in	in	IN
cord-336510-qzm9wgde	168	19	question	question	NN
cord-336510-qzm9wgde	168	20	[	[	-LRB-
cord-336510-qzm9wgde	168	21	141	141	CD
cord-336510-qzm9wgde	168	22	]	]	-RRB-
cord-336510-qzm9wgde	168	23	.	.	.
cord-336510-qzm9wgde	169	1	The	the	DT
cord-336510-qzm9wgde	169	2	tissue	tissue	NN
cord-336510-qzm9wgde	169	3	macrophages	macrophage	NNS
cord-336510-qzm9wgde	169	4	in	in	IN
cord-336510-qzm9wgde	169	5	the	the	DT
cord-336510-qzm9wgde	169	6	major	major	JJ
cord-336510-qzm9wgde	169	7	organs	organ	NNS
cord-336510-qzm9wgde	169	8	are	be	VBP
cord-336510-qzm9wgde	169	9	represented	represent	VBN
cord-336510-qzm9wgde	169	10	by	by	IN
cord-336510-qzm9wgde	169	11	Kupffer	Kupffer	NNP
cord-336510-qzm9wgde	169	12	cells	cell	NNS
cord-336510-qzm9wgde	169	13	in	in	IN
cord-336510-qzm9wgde	169	14	the	the	DT
cord-336510-qzm9wgde	169	15	liver	liver	NN
cord-336510-qzm9wgde	169	16	,	,	,
cord-336510-qzm9wgde	169	17	alveolar	alveolar	NN
cord-336510-qzm9wgde	169	18	and	and	CC
cord-336510-qzm9wgde	169	19	interstitial	interstitial	JJ
cord-336510-qzm9wgde	169	20	lung	lung	NN
cord-336510-qzm9wgde	169	21	macrophages	macrophage	NNS
cord-336510-qzm9wgde	169	22	,	,	,
cord-336510-qzm9wgde	169	23	spleenic	spleenic	JJ
cord-336510-qzm9wgde	169	24	and	and	CC
cord-336510-qzm9wgde	169	25	sinusoidal	sinusoidal	JJ
cord-336510-qzm9wgde	169	26	lymph	lymph	NN
cord-336510-qzm9wgde	169	27	node	node	NN
cord-336510-qzm9wgde	169	28	macrophages	macrophage	NNS
cord-336510-qzm9wgde	169	29	,	,	,
cord-336510-qzm9wgde	169	30	microglia	microglia	NNS
cord-336510-qzm9wgde	169	31	in	in	IN
cord-336510-qzm9wgde	169	32	the	the	DT
cord-336510-qzm9wgde	169	33	brain	brain	NN
cord-336510-qzm9wgde	169	34	,	,	,
cord-336510-qzm9wgde	169	35	osteoclasts	osteoclast	NNS
cord-336510-qzm9wgde	169	36	in	in	IN
cord-336510-qzm9wgde	169	37	bone	bone	NN
cord-336510-qzm9wgde	169	38	,	,	,
cord-336510-qzm9wgde	169	39	and	and	CC
cord-336510-qzm9wgde	169	40	Langerhans	Langerhans	NNP
cord-336510-qzm9wgde	169	41	cells	cell	NNS
cord-336510-qzm9wgde	169	42	of	of	IN
cord-336510-qzm9wgde	169	43	the	the	DT
cord-336510-qzm9wgde	169	44	skin	skin	NN
cord-336510-qzm9wgde	169	45	.	.	.
cord-336510-qzm9wgde	170	1	Thus	thus	RB
cord-336510-qzm9wgde	170	2	,	,	,
cord-336510-qzm9wgde	170	3	macrophages	macrophage	NNS
cord-336510-qzm9wgde	170	4	are	be	VBP
cord-336510-qzm9wgde	170	5	strategically	strategically	RB
cord-336510-qzm9wgde	170	6	situated	situate	VBN
cord-336510-qzm9wgde	170	7	all	all	RB
cord-336510-qzm9wgde	170	8	over	over	IN
cord-336510-qzm9wgde	170	9	the	the	DT
cord-336510-qzm9wgde	170	10	body	body	NN
cord-336510-qzm9wgde	170	11	taking	take	VBG
cord-336510-qzm9wgde	170	12	care	care	NN
cord-336510-qzm9wgde	170	13	of	of	IN
cord-336510-qzm9wgde	170	14	debris	debris	NN
cord-336510-qzm9wgde	170	15	from	from	IN
cord-336510-qzm9wgde	170	16	the	the	DT
cord-336510-qzm9wgde	170	17	organism	organism	NN
cord-336510-qzm9wgde	170	18	itself	-PRON-	PRP
cord-336510-qzm9wgde	170	19	and	and	CC
cord-336510-qzm9wgde	170	20	foreign	foreign	JJ
cord-336510-qzm9wgde	170	21	material	material	NN
cord-336510-qzm9wgde	170	22	,	,	,
cord-336510-qzm9wgde	170	23	among	among	IN
cord-336510-qzm9wgde	170	24	others	other	NNS
cord-336510-qzm9wgde	170	25	invading	invade	VBG
cord-336510-qzm9wgde	170	26	microorganisms	microorganism	NNS
cord-336510-qzm9wgde	170	27	,	,	,
cord-336510-qzm9wgde	170	28	including	include	VBG
cord-336510-qzm9wgde	170	29	viruses	virus	NNS
cord-336510-qzm9wgde	170	30	[	[	-LRB-
cord-336510-qzm9wgde	170	31	142	142	CD
cord-336510-qzm9wgde	170	32	,	,	,
cord-336510-qzm9wgde	170	33	143	143	CD
cord-336510-qzm9wgde	170	34	]	]	-RRB-
cord-336510-qzm9wgde	170	35	.	.	.
cord-336510-qzm9wgde	171	1	Macrophages	macrophage	NNS
cord-336510-qzm9wgde	171	2	in	in	IN
cord-336510-qzm9wgde	171	3	different	different	JJ
cord-336510-qzm9wgde	171	4	organs	organ	NNS
cord-336510-qzm9wgde	171	5	have	have	VBP
cord-336510-qzm9wgde	171	6	different	different	JJ
cord-336510-qzm9wgde	171	7	characteristics	characteristic	NNS
cord-336510-qzm9wgde	171	8	and	and	CC
cord-336510-qzm9wgde	171	9	functional	functional	JJ
cord-336510-qzm9wgde	171	10	capabilities	capability	NNS
cord-336510-qzm9wgde	171	11	and	and	CC
cord-336510-qzm9wgde	171	12	can	can	MD
cord-336510-qzm9wgde	171	13	not	not	RB
cord-336510-qzm9wgde	171	14	totally	totally	RB
cord-336510-qzm9wgde	171	15	substitute	substitute	VB
cord-336510-qzm9wgde	171	16	one	one	CD
cord-336510-qzm9wgde	171	17	another	another	DT
cord-336510-qzm9wgde	171	18	in	in	IN
cord-336510-qzm9wgde	171	19	studies	study	NNS
cord-336510-qzm9wgde	171	20	on	on	IN
cord-336510-qzm9wgde	171	21	macrophages	macrophage	NNS
cord-336510-qzm9wgde	171	22	[	[	-LRB-
cord-336510-qzm9wgde	171	23	141	141	CD
cord-336510-qzm9wgde	171	24	,	,	,
cord-336510-qzm9wgde	171	25	[	[	-LRB-
cord-336510-qzm9wgde	171	26	144	144	CD
cord-336510-qzm9wgde	171	27	]	]	-RRB-
cord-336510-qzm9wgde	172	1	[	[	-LRB-
cord-336510-qzm9wgde	172	2	145	145	CD
cord-336510-qzm9wgde	172	3	]	]	-RRB-
cord-336510-qzm9wgde	173	1	[	[	-LRB-
cord-336510-qzm9wgde	173	2	146	146	CD
cord-336510-qzm9wgde	173	3	]	]	-RRB-
cord-336510-qzm9wgde	173	4	[	[	-LRB-
cord-336510-qzm9wgde	173	5	147	147	CD
cord-336510-qzm9wgde	173	6	]	]	-RRB-
cord-336510-qzm9wgde	173	7	.	.	.
cord-336510-qzm9wgde	174	1	Likewise	likewise	RB
cord-336510-qzm9wgde	174	2	,	,	,
cord-336510-qzm9wgde	174	3	macrophages	macrophage	NNS
cord-336510-qzm9wgde	174	4	from	from	IN
cord-336510-qzm9wgde	174	5	different	different	JJ
cord-336510-qzm9wgde	174	6	species	specie	NNS
cord-336510-qzm9wgde	174	7	can	can	MD
cord-336510-qzm9wgde	174	8	possess	possess	VB
cord-336510-qzm9wgde	174	9	differences	difference	NNS
cord-336510-qzm9wgde	174	10	in	in	IN
cord-336510-qzm9wgde	174	11	their	-PRON-	PRP$
cord-336510-qzm9wgde	174	12	functional	functional	JJ
cord-336510-qzm9wgde	174	13	capability	capability	NN
cord-336510-qzm9wgde	174	14	,	,	,
cord-336510-qzm9wgde	174	15	e.g.	e.g.	IN
cord-336510-qzm9wgde	174	16	the	the	DT
cord-336510-qzm9wgde	174	17	capacity	capacity	NN
cord-336510-qzm9wgde	174	18	for	for	IN
cord-336510-qzm9wgde	174	19	nitric	nitric	NN
cord-336510-qzm9wgde	174	20	oxide	oxide	NN
cord-336510-qzm9wgde	174	21	(	(	-LRB-
cord-336510-qzm9wgde	174	22	NO	no	UH
cord-336510-qzm9wgde	174	23	)	)	-RRB-
cord-336510-qzm9wgde	174	24	production	production	NN
cord-336510-qzm9wgde	174	25	[	[	-LRB-
cord-336510-qzm9wgde	174	26	148	148	CD
cord-336510-qzm9wgde	174	27	,	,	,
cord-336510-qzm9wgde	174	28	149	149	CD
cord-336510-qzm9wgde	174	29	]	]	-RRB-
cord-336510-qzm9wgde	174	30	.	.	.
cord-336510-qzm9wgde	175	1	Macrophages	macrophage	NNS
cord-336510-qzm9wgde	175	2	in	in	IN
cord-336510-qzm9wgde	175	3	tissues	tissue	NNS
cord-336510-qzm9wgde	175	4	are	be	VBP
cord-336510-qzm9wgde	175	5	,	,	,
cord-336510-qzm9wgde	175	6	as	as	IN
cord-336510-qzm9wgde	175	7	described	describe	VBN
cord-336510-qzm9wgde	175	8	above	above	RB
cord-336510-qzm9wgde	175	9	,	,	,
cord-336510-qzm9wgde	175	10	in	in	IN
cord-336510-qzm9wgde	175	11	part	part	NN
cord-336510-qzm9wgde	175	12	originating	originate	VBG
cord-336510-qzm9wgde	175	13	directly	directly	RB
cord-336510-qzm9wgde	175	14	from	from	IN
cord-336510-qzm9wgde	175	15	monocytes	monocyte	NNS
cord-336510-qzm9wgde	175	16	,	,	,
cord-336510-qzm9wgde	175	17	but	but	CC
cord-336510-qzm9wgde	175	18	they	-PRON-	PRP
cord-336510-qzm9wgde	175	19	are	be	VBP
cord-336510-qzm9wgde	175	20	also	also	RB
cord-336510-qzm9wgde	175	21	in	in	IN
cord-336510-qzm9wgde	175	22	part	part	NN
cord-336510-qzm9wgde	175	23	originating	originate	VBG
cord-336510-qzm9wgde	175	24	from	from	IN
cord-336510-qzm9wgde	175	25	local	local	JJ
cord-336510-qzm9wgde	175	26	proliferation	proliferation	NN
cord-336510-qzm9wgde	175	27	.	.	.
cord-336510-qzm9wgde	176	1	This	this	DT
cord-336510-qzm9wgde	176	2	local	local	JJ
cord-336510-qzm9wgde	176	3	proliferation	proliferation	NN
cord-336510-qzm9wgde	176	4	in	in	IN
cord-336510-qzm9wgde	176	5	the	the	DT
cord-336510-qzm9wgde	176	6	tissues	tissue	NNS
cord-336510-qzm9wgde	176	7	is	be	VBZ
cord-336510-qzm9wgde	176	8	performed	perform	VBN
cord-336510-qzm9wgde	176	9	by	by	IN
cord-336510-qzm9wgde	176	10	newly	newly	RB
cord-336510-qzm9wgde	176	11	recruited	recruit	VBN
cord-336510-qzm9wgde	176	12	monocytes	monocyte	NNS
cord-336510-qzm9wgde	176	13	,	,	,
cord-336510-qzm9wgde	176	14	and	and	CC
cord-336510-qzm9wgde	176	15	in	in	IN
cord-336510-qzm9wgde	176	16	the	the	DT
cord-336510-qzm9wgde	176	17	steady	steady	JJ
cord-336510-qzm9wgde	176	18	state	state	NN
cord-336510-qzm9wgde	176	19	situation	situation	NN
cord-336510-qzm9wgde	176	20	they	-PRON-	PRP
cord-336510-qzm9wgde	176	21	only	only	RB
cord-336510-qzm9wgde	176	22	constitute	constitute	VBP
cord-336510-qzm9wgde	176	23	a	a	DT
cord-336510-qzm9wgde	176	24	small	small	JJ
cord-336510-qzm9wgde	176	25	fraction	fraction	NN
cord-336510-qzm9wgde	176	26	of	of	IN
cord-336510-qzm9wgde	176	27	the	the	DT
cord-336510-qzm9wgde	176	28	mononuclear	mononuclear	JJ
cord-336510-qzm9wgde	176	29	phagocytes	phagocyte	NNS
cord-336510-qzm9wgde	176	30	present	present	VBP
cord-336510-qzm9wgde	176	31	[	[	-LRB-
cord-336510-qzm9wgde	176	32	150	150	CD
cord-336510-qzm9wgde	176	33	]	]	-RRB-
cord-336510-qzm9wgde	176	34	.	.	.
cord-336510-qzm9wgde	177	1	Of	of	IN
cord-336510-qzm9wgde	177	2	the	the	DT
cord-336510-qzm9wgde	177	3	monocytes	monocyte	NNS
cord-336510-qzm9wgde	177	4	produced	produce	VBN
cord-336510-qzm9wgde	177	5	in	in	IN
cord-336510-qzm9wgde	177	6	the	the	DT
cord-336510-qzm9wgde	177	7	bone	bone	NN
cord-336510-qzm9wgde	177	8	marrow	marrow	NN
cord-336510-qzm9wgde	177	9	of	of	IN
cord-336510-qzm9wgde	177	10	mice	mouse	NNS
cord-336510-qzm9wgde	177	11	and	and	CC
cord-336510-qzm9wgde	177	12	passing	pass	VBG
cord-336510-qzm9wgde	177	13	through	through	IN
cord-336510-qzm9wgde	177	14	the	the	DT
cord-336510-qzm9wgde	177	15	blood	blood	NN
cord-336510-qzm9wgde	177	16	,	,	,
cord-336510-qzm9wgde	177	17	approximately	approximately	RB
cord-336510-qzm9wgde	177	18	half	half	NN
cord-336510-qzm9wgde	177	19	are	be	VBP
cord-336510-qzm9wgde	177	20	targeting	target	VBG
cord-336510-qzm9wgde	177	21	the	the	DT
cord-336510-qzm9wgde	177	22	liver	liver	NN
cord-336510-qzm9wgde	177	23	,	,	,
cord-336510-qzm9wgde	177	24	15	15	CD
cord-336510-qzm9wgde	177	25	%	%	NN
cord-336510-qzm9wgde	177	26	are	be	VBP
cord-336510-qzm9wgde	177	27	going	go	VBG
cord-336510-qzm9wgde	177	28	to	to	IN
cord-336510-qzm9wgde	177	29	the	the	DT
cord-336510-qzm9wgde	177	30	lungs	lung	NNS
cord-336510-qzm9wgde	177	31	,	,	,
cord-336510-qzm9wgde	177	32	25	25	CD
cord-336510-qzm9wgde	177	33	%	%	NN
cord-336510-qzm9wgde	177	34	to	to	IN
cord-336510-qzm9wgde	177	35	the	the	DT
cord-336510-qzm9wgde	177	36	spleen	spleen	NNS
cord-336510-qzm9wgde	177	37	and	and	CC
cord-336510-qzm9wgde	177	38	7	7	CD
cord-336510-qzm9wgde	177	39	%	%	NN
cord-336510-qzm9wgde	177	40	to	to	IN
cord-336510-qzm9wgde	177	41	the	the	DT
cord-336510-qzm9wgde	177	42	peritoneal	peritoneal	JJ
cord-336510-qzm9wgde	177	43	cavity	cavity	NN
cord-336510-qzm9wgde	177	44	[	[	-LRB-
cord-336510-qzm9wgde	177	45	150	150	CD
cord-336510-qzm9wgde	177	46	]	]	-RRB-
cord-336510-qzm9wgde	177	47	[	[	-LRB-
cord-336510-qzm9wgde	177	48	151	151	CD
cord-336510-qzm9wgde	177	49	]	]	-RRB-
cord-336510-qzm9wgde	177	50	[	[	-LRB-
cord-336510-qzm9wgde	177	51	152	152	CD
cord-336510-qzm9wgde	177	52	]	]	-RRB-
cord-336510-qzm9wgde	177	53	.	.	.
cord-336510-qzm9wgde	178	1	In	in	IN
cord-336510-qzm9wgde	178	2	the	the	DT
cord-336510-qzm9wgde	178	3	lungs	lung	NNS
cord-336510-qzm9wgde	178	4	,	,	,
cord-336510-qzm9wgde	178	5	70	70	CD
cord-336510-qzm9wgde	178	6	%	%	NN
cord-336510-qzm9wgde	178	7	of	of	IN
cord-336510-qzm9wgde	178	8	tissue	tissue	NN
cord-336510-qzm9wgde	178	9	macrophages	macrophage	NNS
cord-336510-qzm9wgde	178	10	in	in	IN
cord-336510-qzm9wgde	178	11	the	the	DT
cord-336510-qzm9wgde	178	12	steady	steady	JJ
cord-336510-qzm9wgde	178	13	-	-	HYPH
cord-336510-qzm9wgde	178	14	state	state	NN
cord-336510-qzm9wgde	178	15	originate	originate	VBP
cord-336510-qzm9wgde	178	16	from	from	IN
cord-336510-qzm9wgde	178	17	monocyte	monocyte	NNP
cord-336510-qzm9wgde	178	18	influx	influx	NN
cord-336510-qzm9wgde	178	19	and	and	CC
cord-336510-qzm9wgde	178	20	30	30	CD
cord-336510-qzm9wgde	178	21	%	%	NN
cord-336510-qzm9wgde	178	22	from	from	IN
cord-336510-qzm9wgde	178	23	local	local	JJ
cord-336510-qzm9wgde	178	24	proliferation	proliferation	NN
cord-336510-qzm9wgde	178	25	[	[	-LRB-
cord-336510-qzm9wgde	178	26	153	153	CD
cord-336510-qzm9wgde	178	27	]	]	-RRB-
cord-336510-qzm9wgde	178	28	.	.	.
cord-336510-qzm9wgde	179	1	This	this	DT
cord-336510-qzm9wgde	179	2	proportion	proportion	NN
cord-336510-qzm9wgde	179	3	might	may	MD
cord-336510-qzm9wgde	179	4	vary	vary	VB
cord-336510-qzm9wgde	179	5	between	between	IN
cord-336510-qzm9wgde	179	6	different	different	JJ
cord-336510-qzm9wgde	179	7	tissues	tissue	NNS
cord-336510-qzm9wgde	179	8	,	,	,
cord-336510-qzm9wgde	179	9	as	as	IN
cord-336510-qzm9wgde	179	10	the	the	DT
cord-336510-qzm9wgde	179	11	lifespan	lifespan	NN
cord-336510-qzm9wgde	179	12	of	of	IN
cord-336510-qzm9wgde	179	13	tissue	tissue	NN
cord-336510-qzm9wgde	179	14	macrophages	macrophage	NNS
cord-336510-qzm9wgde	179	15	in	in	IN
cord-336510-qzm9wgde	179	16	different	different	JJ
cord-336510-qzm9wgde	179	17	organs	organ	NNS
cord-336510-qzm9wgde	179	18	also	also	RB
cord-336510-qzm9wgde	179	19	varies	vary	VBZ
cord-336510-qzm9wgde	179	20	from	from	IN
cord-336510-qzm9wgde	179	21	around	around	IN
cord-336510-qzm9wgde	179	22	6	6	CD
cord-336510-qzm9wgde	179	23	days	day	NNS
cord-336510-qzm9wgde	179	24	in	in	IN
cord-336510-qzm9wgde	179	25	mouse	mouse	NN
cord-336510-qzm9wgde	179	26	spleen	spleen	NNS
cord-336510-qzm9wgde	179	27	to	to	IN
cord-336510-qzm9wgde	179	28	approximately	approximately	RB
cord-336510-qzm9wgde	179	29	one	one	CD
cord-336510-qzm9wgde	179	30	month	month	NN
cord-336510-qzm9wgde	179	31	for	for	IN
cord-336510-qzm9wgde	179	32	alveolar	alveolar	JJ
cord-336510-qzm9wgde	179	33	macrophages	macrophage	NNS
cord-336510-qzm9wgde	179	34	[	[	-LRB-
cord-336510-qzm9wgde	179	35	151	151	CD
cord-336510-qzm9wgde	179	36	,	,	,
cord-336510-qzm9wgde	179	37	152	152	CD
cord-336510-qzm9wgde	179	38	]	]	-RRB-
cord-336510-qzm9wgde	179	39	.	.	.
cord-336510-qzm9wgde	180	1	In	in	IN
cord-336510-qzm9wgde	180	2	the	the	DT
cord-336510-qzm9wgde	180	3	skin	skin	NN
cord-336510-qzm9wgde	180	4	,	,	,
cord-336510-qzm9wgde	180	5	Langerhans	Langerhans	NNP
cord-336510-qzm9wgde	180	6	cells	cell	NNS
cord-336510-qzm9wgde	180	7	are	be	VBP
cord-336510-qzm9wgde	180	8	a	a	DT
cord-336510-qzm9wgde	180	9	very	very	RB
cord-336510-qzm9wgde	180	10	stable	stable	JJ
cord-336510-qzm9wgde	180	11	and	and	CC
cord-336510-qzm9wgde	180	12	long	long	RB
cord-336510-qzm9wgde	180	13	-	-	HYPH
cord-336510-qzm9wgde	180	14	lived	live	VBN
cord-336510-qzm9wgde	180	15	population	population	NN
cord-336510-qzm9wgde	180	16	of	of	IN
cord-336510-qzm9wgde	180	17	cells	cell	NNS
cord-336510-qzm9wgde	180	18	staying	stay	VBG
cord-336510-qzm9wgde	180	19	there	there	RB
cord-336510-qzm9wgde	180	20	for	for	IN
cord-336510-qzm9wgde	180	21	at	at	RB
cord-336510-qzm9wgde	180	22	least	least	RBS
cord-336510-qzm9wgde	180	23	18	18	CD
cord-336510-qzm9wgde	180	24	month	month	NN
cord-336510-qzm9wgde	180	25	in	in	IN
cord-336510-qzm9wgde	180	26	the	the	DT
cord-336510-qzm9wgde	180	27	steady	steady	JJ
cord-336510-qzm9wgde	180	28	-	-	HYPH
cord-336510-qzm9wgde	180	29	state	state	NN
cord-336510-qzm9wgde	180	30	situation	situation	NN
cord-336510-qzm9wgde	180	31	.	.	.
cord-336510-qzm9wgde	181	1	However	however	RB
cord-336510-qzm9wgde	181	2	,	,	,
cord-336510-qzm9wgde	181	3	in	in	IN
cord-336510-qzm9wgde	181	4	inflammation	inflammation	NN
cord-336510-qzm9wgde	181	5	the	the	DT
cord-336510-qzm9wgde	181	6	Langerhans	Langerhans	NNP
cord-336510-qzm9wgde	181	7	cells	cell	NNS
cord-336510-qzm9wgde	181	8	are	be	VBP
cord-336510-qzm9wgde	181	9	within	within	IN
cord-336510-qzm9wgde	181	10	2	2	CD
cord-336510-qzm9wgde	181	11	weeks	week	NNS
cord-336510-qzm9wgde	181	12	replaced	replace	VBN
cord-336510-qzm9wgde	181	13	and	and	CC
cord-336510-qzm9wgde	181	14	supplemented	supplement	VBN
cord-336510-qzm9wgde	181	15	by	by	IN
cord-336510-qzm9wgde	181	16	circulating	circulate	VBG
cord-336510-qzm9wgde	181	17	mononuclear	mononuclear	JJ
cord-336510-qzm9wgde	181	18	cells	cell	NNS
cord-336510-qzm9wgde	181	19	[	[	-LRB-
cord-336510-qzm9wgde	181	20	154	154	CD
cord-336510-qzm9wgde	181	21	]	]	-RRB-
cord-336510-qzm9wgde	181	22	.	.	.
cord-336510-qzm9wgde	182	1	When	when	WRB
cord-336510-qzm9wgde	182	2	an	an	DT
cord-336510-qzm9wgde	182	3	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	182	4	process	process	NN
cord-336510-qzm9wgde	182	5	is	be	VBZ
cord-336510-qzm9wgde	182	6	initiated	initiate	VBN
cord-336510-qzm9wgde	182	7	,	,	,
cord-336510-qzm9wgde	182	8	the	the	DT
cord-336510-qzm9wgde	182	9	dynamics	dynamic	NNS
cord-336510-qzm9wgde	182	10	of	of	IN
cord-336510-qzm9wgde	182	11	monocytes	monocyte	NNS
cord-336510-qzm9wgde	182	12	and	and	CC
cord-336510-qzm9wgde	182	13	macrophages	macrophage	NNS
cord-336510-qzm9wgde	182	14	are	be	VBP
cord-336510-qzm9wgde	182	15	changed	change	VBN
cord-336510-qzm9wgde	182	16	.	.	.
cord-336510-qzm9wgde	183	1	Monocytes	monocyte	NNS
cord-336510-qzm9wgde	183	2	and	and	CC
cord-336510-qzm9wgde	183	3	other	other	JJ
cord-336510-qzm9wgde	183	4	white	white	JJ
cord-336510-qzm9wgde	183	5	blood	blood	NN
cord-336510-qzm9wgde	183	6	cells	cell	NNS
cord-336510-qzm9wgde	183	7	are	be	VBP
cord-336510-qzm9wgde	183	8	produced	produce	VBN
cord-336510-qzm9wgde	183	9	and	and	CC
cord-336510-qzm9wgde	183	10	recruited	recruit	VBN
cord-336510-qzm9wgde	183	11	from	from	IN
cord-336510-qzm9wgde	183	12	the	the	DT
cord-336510-qzm9wgde	183	13	bone	bone	NN
cord-336510-qzm9wgde	183	14	marrow	marrow	NN
cord-336510-qzm9wgde	183	15	,	,	,
cord-336510-qzm9wgde	183	16	and	and	CC
cord-336510-qzm9wgde	183	17	the	the	DT
cord-336510-qzm9wgde	183	18	white	white	JJ
cord-336510-qzm9wgde	183	19	blood	blood	NN
cord-336510-qzm9wgde	183	20	cell	cell	NN
cord-336510-qzm9wgde	183	21	count	count	NN
cord-336510-qzm9wgde	183	22	in	in	IN
cord-336510-qzm9wgde	183	23	the	the	DT
cord-336510-qzm9wgde	183	24	circulation	circulation	NN
cord-336510-qzm9wgde	183	25	is	be	VBZ
cord-336510-qzm9wgde	183	26	increased	increase	VBN
cord-336510-qzm9wgde	183	27	.	.	.
cord-336510-qzm9wgde	184	1	The	the	DT
cord-336510-qzm9wgde	184	2	monocytes	monocyte	NNS
cord-336510-qzm9wgde	184	3	are	be	VBP
cord-336510-qzm9wgde	184	4	mainly	mainly	RB
cord-336510-qzm9wgde	184	5	passing	pass	VBG
cord-336510-qzm9wgde	184	6	through	through	IN
cord-336510-qzm9wgde	184	7	the	the	DT
cord-336510-qzm9wgde	184	8	blood	blood	NN
cord-336510-qzm9wgde	184	9	to	to	TO
cord-336510-qzm9wgde	184	10	become	become	VB
cord-336510-qzm9wgde	184	11	tissue	tissue	NN
cord-336510-qzm9wgde	184	12	macrophages	macrophage	NNS
cord-336510-qzm9wgde	184	13	,	,	,
cord-336510-qzm9wgde	184	14	and	and	CC
cord-336510-qzm9wgde	184	15	the	the	DT
cord-336510-qzm9wgde	184	16	number	number	NN
cord-336510-qzm9wgde	184	17	of	of	IN
cord-336510-qzm9wgde	184	18	macrophages	macrophage	NNS
cord-336510-qzm9wgde	184	19	in	in	IN
cord-336510-qzm9wgde	184	20	the	the	DT
cord-336510-qzm9wgde	184	21	inflamed	inflamed	JJ
cord-336510-qzm9wgde	184	22	tissue	tissue	NN
cord-336510-qzm9wgde	184	23	can	can	MD
cord-336510-qzm9wgde	184	24	be	be	VB
cord-336510-qzm9wgde	184	25	increased	increase	VBN
cord-336510-qzm9wgde	184	26	by	by	IN
cord-336510-qzm9wgde	184	27	more	more	JJR
cord-336510-qzm9wgde	184	28	than	than	IN
cord-336510-qzm9wgde	184	29	ten	ten	CD
cord-336510-qzm9wgde	184	30	times	time	NNS
cord-336510-qzm9wgde	184	31	[	[	-LRB-
cord-336510-qzm9wgde	184	32	155	155	CD
cord-336510-qzm9wgde	184	33	]	]	-RRB-
cord-336510-qzm9wgde	184	34	.	.	.
cord-336510-qzm9wgde	185	1	In	in	IN
cord-336510-qzm9wgde	185	2	inflamed	inflamed	JJ
cord-336510-qzm9wgde	185	3	tissue	tissue	NN
cord-336510-qzm9wgde	185	4	the	the	DT
cord-336510-qzm9wgde	185	5	local	local	JJ
cord-336510-qzm9wgde	185	6	proliferation	proliferation	NN
cord-336510-qzm9wgde	185	7	of	of	IN
cord-336510-qzm9wgde	185	8	macrophages	macrophage	NNS
cord-336510-qzm9wgde	185	9	does	do	VBZ
cord-336510-qzm9wgde	185	10	not	not	RB
cord-336510-qzm9wgde	185	11	seem	seem	VB
cord-336510-qzm9wgde	185	12	to	to	TO
cord-336510-qzm9wgde	185	13	increase	increase	VB
cord-336510-qzm9wgde	185	14	,	,	,
cord-336510-qzm9wgde	185	15	although	although	IN
cord-336510-qzm9wgde	185	16	the	the	DT
cord-336510-qzm9wgde	185	17	number	number	NN
cord-336510-qzm9wgde	185	18	of	of	IN
cord-336510-qzm9wgde	185	19	newly	newly	RB
cord-336510-qzm9wgde	185	20	recruited	recruit	VBN
cord-336510-qzm9wgde	185	21	cells	cell	NNS
cord-336510-qzm9wgde	185	22	is	be	VBZ
cord-336510-qzm9wgde	185	23	high	high	JJ
cord-336510-qzm9wgde	185	24	,	,	,
cord-336510-qzm9wgde	185	25	indicating	indicate	VBG
cord-336510-qzm9wgde	185	26	that	that	IN
cord-336510-qzm9wgde	185	27	the	the	DT
cord-336510-qzm9wgde	185	28	differentiation	differentiation	NN
cord-336510-qzm9wgde	185	29	of	of	IN
cord-336510-qzm9wgde	185	30	monocytes	monocyte	NNS
cord-336510-qzm9wgde	185	31	in	in	IN
cord-336510-qzm9wgde	185	32	the	the	DT
cord-336510-qzm9wgde	185	33	tissues	tissue	NNS
cord-336510-qzm9wgde	185	34	is	be	VBZ
cord-336510-qzm9wgde	185	35	accelerated	accelerate	VBN
cord-336510-qzm9wgde	185	36	[	[	-LRB-
cord-336510-qzm9wgde	185	37	155	155	CD
cord-336510-qzm9wgde	185	38	]	]	-RRB-
cord-336510-qzm9wgde	185	39	.	.	.
cord-336510-qzm9wgde	186	1	The	the	DT
cord-336510-qzm9wgde	186	2	differentiation	differentiation	NN
cord-336510-qzm9wgde	186	3	of	of	IN
cord-336510-qzm9wgde	186	4	monocytes	monocyte	NNS
cord-336510-qzm9wgde	186	5	and	and	CC
cord-336510-qzm9wgde	186	6	activation	activation	NN
cord-336510-qzm9wgde	186	7	of	of	IN
cord-336510-qzm9wgde	186	8	macrophages	macrophage	NNS
cord-336510-qzm9wgde	186	9	have	have	VBP
cord-336510-qzm9wgde	186	10	been	be	VBN
cord-336510-qzm9wgde	186	11	a	a	DT
cord-336510-qzm9wgde	186	12	focus	focus	NN
cord-336510-qzm9wgde	186	13	of	of	IN
cord-336510-qzm9wgde	186	14	interest	interest	NN
cord-336510-qzm9wgde	186	15	for	for	IN
cord-336510-qzm9wgde	186	16	many	many	JJ
cord-336510-qzm9wgde	186	17	years	year	NNS
cord-336510-qzm9wgde	186	18	because	because	IN
cord-336510-qzm9wgde	186	19	of	of	IN
cord-336510-qzm9wgde	186	20	the	the	DT
cord-336510-qzm9wgde	186	21	observation	observation	NN
cord-336510-qzm9wgde	186	22	that	that	IN
cord-336510-qzm9wgde	186	23	macrophage	macrophage	NN
cord-336510-qzm9wgde	186	24	activation	activation	NN
cord-336510-qzm9wgde	186	25	is	be	VBZ
cord-336510-qzm9wgde	186	26	crucial	crucial	JJ
cord-336510-qzm9wgde	186	27	in	in	IN
cord-336510-qzm9wgde	186	28	the	the	DT
cord-336510-qzm9wgde	186	29	defence	defence	NN
cord-336510-qzm9wgde	186	30	against	against	IN
cord-336510-qzm9wgde	186	31	many	many	JJ
cord-336510-qzm9wgde	186	32	intracellular	intracellular	JJ
cord-336510-qzm9wgde	186	33	pathogens	pathogen	NNS
cord-336510-qzm9wgde	186	34	[	[	-LRB-
cord-336510-qzm9wgde	186	35	156	156	CD
cord-336510-qzm9wgde	186	36	]	]	-RRB-
cord-336510-qzm9wgde	186	37	[	[	-LRB-
cord-336510-qzm9wgde	186	38	157	157	CD
cord-336510-qzm9wgde	186	39	]	]	-RRB-
cord-336510-qzm9wgde	186	40	[	[	-LRB-
cord-336510-qzm9wgde	186	41	158	158	CD
cord-336510-qzm9wgde	186	42	]	]	-RRB-
cord-336510-qzm9wgde	186	43	[	[	-LRB-
cord-336510-qzm9wgde	186	44	159	159	CD
cord-336510-qzm9wgde	186	45	]	]	-RRB-
cord-336510-qzm9wgde	186	46	.	.	.
cord-336510-qzm9wgde	187	1	It	-PRON-	PRP
cord-336510-qzm9wgde	187	2	became	become	VBD
cord-336510-qzm9wgde	187	3	clear	clear	JJ
cord-336510-qzm9wgde	187	4	relatively	relatively	RB
cord-336510-qzm9wgde	187	5	early	early	RB
cord-336510-qzm9wgde	187	6	that	that	IN
cord-336510-qzm9wgde	187	7	lymphocytes	lymphocyte	NNS
cord-336510-qzm9wgde	187	8	and	and	CC
cord-336510-qzm9wgde	187	9	soluble	soluble	JJ
cord-336510-qzm9wgde	187	10	factors	factor	NNS
cord-336510-qzm9wgde	187	11	secreted	secrete	VBN
cord-336510-qzm9wgde	187	12	by	by	IN
cord-336510-qzm9wgde	187	13	these	these	DT
cord-336510-qzm9wgde	187	14	(	(	-LRB-
cord-336510-qzm9wgde	187	15	lymphokines	lymphokine	NNS
cord-336510-qzm9wgde	187	16	)	)	-RRB-
cord-336510-qzm9wgde	187	17	are	be	VBP
cord-336510-qzm9wgde	187	18	important	important	JJ
cord-336510-qzm9wgde	187	19	in	in	IN
cord-336510-qzm9wgde	187	20	activation	activation	NN
cord-336510-qzm9wgde	187	21	of	of	IN
cord-336510-qzm9wgde	187	22	macrophages	macrophage	NNS
cord-336510-qzm9wgde	187	23	for	for	IN
cord-336510-qzm9wgde	187	24	killing	kill	VBG
cord-336510-qzm9wgde	187	25	of	of	IN
cord-336510-qzm9wgde	187	26	intracellular	intracellular	JJ
cord-336510-qzm9wgde	187	27	bacteria	bacteria	NNS
cord-336510-qzm9wgde	187	28	,	,	,
cord-336510-qzm9wgde	187	29	e.g.	e.g.	RB
cord-336510-qzm9wgde	187	30	Listeria	Listeria	NNP
cord-336510-qzm9wgde	187	31	[	[	-LRB-
cord-336510-qzm9wgde	187	32	160	160	CD
cord-336510-qzm9wgde	187	33	]	]	-RRB-
cord-336510-qzm9wgde	187	34	.	.	.
cord-336510-qzm9wgde	188	1	In	in	IN
cord-336510-qzm9wgde	188	2	the	the	DT
cord-336510-qzm9wgde	188	3	killing	killing	NN
cord-336510-qzm9wgde	188	4	of	of	IN
cord-336510-qzm9wgde	188	5	bacteria	bacteria	NNS
cord-336510-qzm9wgde	188	6	,	,	,
cord-336510-qzm9wgde	188	7	interferon	interferon	NN
cord-336510-qzm9wgde	188	8	(	(	-LRB-
cord-336510-qzm9wgde	188	9	IFN)-γ	IFN)-γ	NNP
cord-336510-qzm9wgde	188	10	was	be	VBD
cord-336510-qzm9wgde	188	11	shown	show	VBN
cord-336510-qzm9wgde	188	12	to	to	TO
cord-336510-qzm9wgde	188	13	be	be	VB
cord-336510-qzm9wgde	188	14	an	an	DT
cord-336510-qzm9wgde	188	15	important	important	JJ
cord-336510-qzm9wgde	188	16	stimulator	stimulator	NN
cord-336510-qzm9wgde	188	17	of	of	IN
cord-336510-qzm9wgde	188	18	macrophage	macrophage	NN
cord-336510-qzm9wgde	188	19	activation	activation	NN
cord-336510-qzm9wgde	188	20	[	[	-LRB-
cord-336510-qzm9wgde	188	21	161	161	CD
cord-336510-qzm9wgde	188	22	]	]	-RRB-
cord-336510-qzm9wgde	188	23	.	.	.
cord-336510-qzm9wgde	189	1	As	as	IN
cord-336510-qzm9wgde	189	2	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	189	3	in	in	IN
cord-336510-qzm9wgde	189	4	performance	performance	NN
cord-336510-qzm9wgde	189	5	of	of	IN
cord-336510-qzm9wgde	189	6	the	the	DT
cord-336510-qzm9wgde	189	7	killing	kill	VBG
cord-336510-qzm9wgde	189	8	simple	simple	JJ
cord-336510-qzm9wgde	189	9	toxic	toxic	JJ
cord-336510-qzm9wgde	189	10	substances	substance	NNS
cord-336510-qzm9wgde	189	11	of	of	IN
cord-336510-qzm9wgde	189	12	reactive	reactive	JJ
cord-336510-qzm9wgde	189	13	oxygen	oxygen	NN
cord-336510-qzm9wgde	189	14	species	specie	NNS
cord-336510-qzm9wgde	189	15	(	(	-LRB-
cord-336510-qzm9wgde	189	16	ROS	ROS	NNP
cord-336510-qzm9wgde	189	17	)	)	-RRB-
cord-336510-qzm9wgde	189	18	and	and	CC
cord-336510-qzm9wgde	189	19	nitric	nitric	NN
cord-336510-qzm9wgde	189	20	oxide	oxide	NN
cord-336510-qzm9wgde	189	21	were	be	VBD
cord-336510-qzm9wgde	189	22	identified	identify	VBN
cord-336510-qzm9wgde	189	23	and	and	CC
cord-336510-qzm9wgde	189	24	seem	seem	VBP
cord-336510-qzm9wgde	189	25	to	to	TO
cord-336510-qzm9wgde	189	26	conduct	conduct	VB
cord-336510-qzm9wgde	189	27	their	-PRON-	PRP$
cord-336510-qzm9wgde	189	28	action	action	NN
cord-336510-qzm9wgde	189	29	in	in	IN
cord-336510-qzm9wgde	189	30	synergy	synergy	NN
cord-336510-qzm9wgde	189	31	[	[	-LRB-
cord-336510-qzm9wgde	189	32	162	162	CD
cord-336510-qzm9wgde	189	33	]	]	-RRB-
cord-336510-qzm9wgde	189	34	[	[	-LRB-
cord-336510-qzm9wgde	189	35	163	163	CD
cord-336510-qzm9wgde	189	36	]	]	-RRB-
cord-336510-qzm9wgde	189	37	[	[	-LRB-
cord-336510-qzm9wgde	189	38	164	164	CD
cord-336510-qzm9wgde	189	39	]	]	-RRB-
cord-336510-qzm9wgde	189	40	.	.	.
cord-336510-qzm9wgde	190	1	The	the	DT
cord-336510-qzm9wgde	190	2	toxic	toxic	JJ
cord-336510-qzm9wgde	190	3	substances	substance	NNS
cord-336510-qzm9wgde	190	4	are	be	VBP
cord-336510-qzm9wgde	190	5	chemically	chemically	RB
cord-336510-qzm9wgde	190	6	simple	simple	JJ
cord-336510-qzm9wgde	190	7	,	,	,
cord-336510-qzm9wgde	190	8	but	but	CC
cord-336510-qzm9wgde	190	9	their	-PRON-	PRP$
cord-336510-qzm9wgde	190	10	production	production	NN
cord-336510-qzm9wgde	190	11	and	and	CC
cord-336510-qzm9wgde	190	12	regulation	regulation	NN
cord-336510-qzm9wgde	190	13	in	in	IN
cord-336510-qzm9wgde	190	14	macrophages	macrophage	NNS
cord-336510-qzm9wgde	190	15	are	be	VBP
cord-336510-qzm9wgde	190	16	very	very	RB
cord-336510-qzm9wgde	190	17	complex	complex	JJ
cord-336510-qzm9wgde	190	18	and	and	CC
cord-336510-qzm9wgde	190	19	still	still	RB
cord-336510-qzm9wgde	190	20	a	a	DT
cord-336510-qzm9wgde	190	21	matter	matter	NN
cord-336510-qzm9wgde	190	22	of	of	IN
cord-336510-qzm9wgde	190	23	intense	intense	JJ
cord-336510-qzm9wgde	190	24	studies	study	NNS
cord-336510-qzm9wgde	190	25	[	[	-LRB-
cord-336510-qzm9wgde	190	26	149	149	CD
cord-336510-qzm9wgde	190	27	]	]	-RRB-
cord-336510-qzm9wgde	190	28	.	.	.
cord-336510-qzm9wgde	191	1	The	the	DT
cord-336510-qzm9wgde	191	2	state	state	NN
cord-336510-qzm9wgde	191	3	of	of	IN
cord-336510-qzm9wgde	191	4	the	the	DT
cord-336510-qzm9wgde	191	5	activated	activate	VBN
cord-336510-qzm9wgde	191	6	macrophage	macrophage	NN
cord-336510-qzm9wgde	191	7	has	have	VBZ
cord-336510-qzm9wgde	191	8	changed	change	VBN
cord-336510-qzm9wgde	191	9	conceptually	conceptually	RB
cord-336510-qzm9wgde	191	10	from	from	IN
cord-336510-qzm9wgde	191	11	being	be	VBG
cord-336510-qzm9wgde	191	12	viewed	view	VBN
cord-336510-qzm9wgde	191	13	as	as	IN
cord-336510-qzm9wgde	191	14	one	one	CD
cord-336510-qzm9wgde	191	15	specific	specific	JJ
cord-336510-qzm9wgde	191	16	condition	condition	NN
cord-336510-qzm9wgde	191	17	of	of	IN
cord-336510-qzm9wgde	191	18	the	the	DT
cord-336510-qzm9wgde	191	19	cell	cell	NN
cord-336510-qzm9wgde	191	20	towards	towards	IN
cord-336510-qzm9wgde	191	21	a	a	DT
cord-336510-qzm9wgde	191	22	more	more	RBR
cord-336510-qzm9wgde	191	23	dynamic	dynamic	JJ
cord-336510-qzm9wgde	191	24	picture	picture	NN
cord-336510-qzm9wgde	191	25	,	,	,
cord-336510-qzm9wgde	191	26	provoked	provoke	VBN
cord-336510-qzm9wgde	191	27	by	by	IN
cord-336510-qzm9wgde	191	28	the	the	DT
cord-336510-qzm9wgde	191	29	fact	fact	NN
cord-336510-qzm9wgde	191	30	that	that	IN
cord-336510-qzm9wgde	191	31	macrophages	macrophage	NNS
cord-336510-qzm9wgde	191	32	activated	activate	VBN
cord-336510-qzm9wgde	191	33	by	by	IN
cord-336510-qzm9wgde	191	34	different	different	JJ
cord-336510-qzm9wgde	191	35	means	mean	NNS
cord-336510-qzm9wgde	191	36	show	show	VBP
cord-336510-qzm9wgde	191	37	different	different	JJ
cord-336510-qzm9wgde	191	38	phenotypical	phenotypical	JJ
cord-336510-qzm9wgde	191	39	characteristics	characteristic	NNS
cord-336510-qzm9wgde	191	40	[	[	-LRB-
cord-336510-qzm9wgde	191	41	163	163	CD
cord-336510-qzm9wgde	191	42	,	,	,
cord-336510-qzm9wgde	191	43	165	165	CD
cord-336510-qzm9wgde	191	44	]	]	-RRB-
cord-336510-qzm9wgde	191	45	.	.	.
cord-336510-qzm9wgde	192	1	The	the	DT
cord-336510-qzm9wgde	192	2	activated	activate	VBN
cord-336510-qzm9wgde	192	3	macrophage	macrophage	NN
cord-336510-qzm9wgde	192	4	is	be	VBZ
cord-336510-qzm9wgde	192	5	now	now	RB
cord-336510-qzm9wgde	192	6	viewed	view	VBN
cord-336510-qzm9wgde	192	7	as	as	IN
cord-336510-qzm9wgde	192	8	a	a	DT
cord-336510-qzm9wgde	192	9	cell	cell	NN
cord-336510-qzm9wgde	192	10	with	with	IN
cord-336510-qzm9wgde	192	11	floating	float	VBG
cord-336510-qzm9wgde	192	12	characteristics	characteristic	NNS
cord-336510-qzm9wgde	192	13	of	of	IN
cord-336510-qzm9wgde	192	14	many	many	JJ
cord-336510-qzm9wgde	192	15	functional	functional	JJ
cord-336510-qzm9wgde	192	16	capacities	capacity	NNS
cord-336510-qzm9wgde	192	17	regulated	regulate	VBN
cord-336510-qzm9wgde	192	18	by	by	IN
cord-336510-qzm9wgde	192	19	a	a	DT
cord-336510-qzm9wgde	192	20	multitude	multitude	NN
cord-336510-qzm9wgde	192	21	of	of	IN
cord-336510-qzm9wgde	192	22	stimulating	stimulating	JJ
cord-336510-qzm9wgde	192	23	substances	substance	NNS
cord-336510-qzm9wgde	192	24	,	,	,
cord-336510-qzm9wgde	192	25	such	such	JJ
cord-336510-qzm9wgde	192	26	as	as	IN
cord-336510-qzm9wgde	192	27	the	the	DT
cord-336510-qzm9wgde	192	28	cytokine	cytokine	NN
cord-336510-qzm9wgde	192	29	environment	environment	NN
cord-336510-qzm9wgde	192	30	,	,	,
cord-336510-qzm9wgde	192	31	hormones	hormone	NNS
cord-336510-qzm9wgde	192	32	,	,	,
cord-336510-qzm9wgde	192	33	and	and	CC
cord-336510-qzm9wgde	192	34	pathogenic	pathogenic	JJ
cord-336510-qzm9wgde	192	35	and	and	CC
cord-336510-qzm9wgde	192	36	foreign	foreign	JJ
cord-336510-qzm9wgde	192	37	substances	substance	NNS
cord-336510-qzm9wgde	192	38	[	[	-LRB-
cord-336510-qzm9wgde	192	39	147	147	CD
cord-336510-qzm9wgde	192	40	,	,	,
cord-336510-qzm9wgde	192	41	166	166	CD
cord-336510-qzm9wgde	192	42	]	]	-RRB-
cord-336510-qzm9wgde	192	43	.	.	.
cord-336510-qzm9wgde	193	1	Among	among	IN
cord-336510-qzm9wgde	193	2	variables	variable	NNS
cord-336510-qzm9wgde	193	3	,	,	,
cord-336510-qzm9wgde	193	4	controlling	control	VBG
cord-336510-qzm9wgde	193	5	macrophage	macrophage	NN
cord-336510-qzm9wgde	193	6	activity	activity	NN
cord-336510-qzm9wgde	193	7	in	in	IN
cord-336510-qzm9wgde	193	8	infected	infected	JJ
cord-336510-qzm9wgde	193	9	individuals	individual	NNS
cord-336510-qzm9wgde	193	10	,	,	,
cord-336510-qzm9wgde	193	11	are	be	VBP
cord-336510-qzm9wgde	193	12	the	the	DT
cord-336510-qzm9wgde	193	13	genetic	genetic	JJ
cord-336510-qzm9wgde	193	14	constitutions	constitution	NNS
cord-336510-qzm9wgde	193	15	of	of	IN
cord-336510-qzm9wgde	193	16	the	the	DT
cord-336510-qzm9wgde	193	17	host	host	NN
cord-336510-qzm9wgde	193	18	.	.	.
cord-336510-qzm9wgde	194	1	The	the	DT
cord-336510-qzm9wgde	194	2	genetic	genetic	JJ
cord-336510-qzm9wgde	194	3	background	background	NN
cord-336510-qzm9wgde	194	4	has	have	VBZ
cord-336510-qzm9wgde	194	5	been	be	VBN
cord-336510-qzm9wgde	194	6	shown	show	VBN
cord-336510-qzm9wgde	194	7	to	to	TO
cord-336510-qzm9wgde	194	8	be	be	VB
cord-336510-qzm9wgde	194	9	of	of	IN
cord-336510-qzm9wgde	194	10	importance	importance	NN
cord-336510-qzm9wgde	194	11	for	for	IN
cord-336510-qzm9wgde	194	12	the	the	DT
cord-336510-qzm9wgde	194	13	regulation	regulation	NN
cord-336510-qzm9wgde	194	14	of	of	IN
cord-336510-qzm9wgde	194	15	both	both	CC
cord-336510-qzm9wgde	194	16	basic	basic	JJ
cord-336510-qzm9wgde	194	17	proliferation	proliferation	NN
cord-336510-qzm9wgde	194	18	and	and	CC
cord-336510-qzm9wgde	194	19	function	function	NN
cord-336510-qzm9wgde	194	20	of	of	IN
cord-336510-qzm9wgde	194	21	macrophages	macrophage	NNS
cord-336510-qzm9wgde	194	22	and	and	CC
cord-336510-qzm9wgde	194	23	for	for	IN
cord-336510-qzm9wgde	194	24	the	the	DT
cord-336510-qzm9wgde	194	25	more	more	RBR
cord-336510-qzm9wgde	194	26	specific	specific	JJ
cord-336510-qzm9wgde	194	27	antimicrobial	antimicrobial	JJ
cord-336510-qzm9wgde	194	28	responses	response	NNS
cord-336510-qzm9wgde	194	29	[	[	-LRB-
cord-336510-qzm9wgde	194	30	167	167	CD
cord-336510-qzm9wgde	194	31	,	,	,
cord-336510-qzm9wgde	194	32	168	168	CD
cord-336510-qzm9wgde	194	33	]	]	-RRB-
cord-336510-qzm9wgde	194	34	.	.	.
cord-336510-qzm9wgde	195	1	Soluble	soluble	JJ
cord-336510-qzm9wgde	195	2	mediators	mediator	NNS
cord-336510-qzm9wgde	195	3	of	of	IN
cord-336510-qzm9wgde	195	4	lymphocyte	lymphocyte	NN
cord-336510-qzm9wgde	195	5	activities	activity	NNS
cord-336510-qzm9wgde	195	6	were	be	VBD
cord-336510-qzm9wgde	195	7	described	describe	VBN
cord-336510-qzm9wgde	195	8	as	as	RB
cord-336510-qzm9wgde	195	9	early	early	RB
cord-336510-qzm9wgde	195	10	as	as	IN
cord-336510-qzm9wgde	195	11	1953	1953	CD
cord-336510-qzm9wgde	195	12	,	,	,
cord-336510-qzm9wgde	195	13	but	but	CC
cord-336510-qzm9wgde	195	14	the	the	DT
cord-336510-qzm9wgde	195	15	first	first	JJ
cord-336510-qzm9wgde	195	16	lymphokines	lymphokine	NNS
cord-336510-qzm9wgde	195	17	/	/	SYM
cord-336510-qzm9wgde	195	18	cytokines	cytokine	NNS
cord-336510-qzm9wgde	195	19	found	find	VBN
cord-336510-qzm9wgde	195	20	and	and	CC
cord-336510-qzm9wgde	195	21	characterized	characterize	VBN
cord-336510-qzm9wgde	195	22	were	be	VBD
cord-336510-qzm9wgde	195	23	the	the	DT
cord-336510-qzm9wgde	195	24	type	type	NN
cord-336510-qzm9wgde	195	25	I	-PRON-	PRP
cord-336510-qzm9wgde	195	26	interferons	interferon	NNS
cord-336510-qzm9wgde	195	27	.	.	.
cord-336510-qzm9wgde	196	1	Soon	soon	RB
cord-336510-qzm9wgde	196	2	after	after	RB
cord-336510-qzm9wgde	196	3	,	,	,
cord-336510-qzm9wgde	196	4	many	many	JJ
cord-336510-qzm9wgde	196	5	other	other	JJ
cord-336510-qzm9wgde	196	6	soluble	soluble	JJ
cord-336510-qzm9wgde	196	7	mediators	mediator	NNS
cord-336510-qzm9wgde	196	8	of	of	IN
cord-336510-qzm9wgde	196	9	lymphocyte	lymphocyte	NN
cord-336510-qzm9wgde	196	10	and	and	CC
cord-336510-qzm9wgde	196	11	monocyte	monocyte	NNP
cord-336510-qzm9wgde	196	12	/	/	SYM
cord-336510-qzm9wgde	196	13	macrophage	macrophage	NN
cord-336510-qzm9wgde	196	14	activities	activity	NNS
cord-336510-qzm9wgde	196	15	were	be	VBD
cord-336510-qzm9wgde	196	16	found	find	VBN
cord-336510-qzm9wgde	196	17	[	[	-LRB-
cord-336510-qzm9wgde	196	18	169	169	CD
cord-336510-qzm9wgde	196	19	]	]	-RRB-
cord-336510-qzm9wgde	196	20	[	[	-LRB-
cord-336510-qzm9wgde	196	21	170	170	CD
cord-336510-qzm9wgde	196	22	]	]	-RRB-
cord-336510-qzm9wgde	196	23	[	[	-LRB-
cord-336510-qzm9wgde	196	24	171	171	CD
cord-336510-qzm9wgde	196	25	]	]	-RRB-
cord-336510-qzm9wgde	196	26	.	.	.
cord-336510-qzm9wgde	197	1	The	the	DT
cord-336510-qzm9wgde	197	2	term	term	NN
cord-336510-qzm9wgde	197	3	lymphokine	lymphokine	NN
cord-336510-qzm9wgde	197	4	was	be	VBD
cord-336510-qzm9wgde	197	5	introduced	introduce	VBN
cord-336510-qzm9wgde	197	6	by	by	IN
cord-336510-qzm9wgde	197	7	Dumonde	Dumonde	NNP
cord-336510-qzm9wgde	197	8	et	et	NNP
cord-336510-qzm9wgde	197	9	al	al	NNP
cord-336510-qzm9wgde	197	10	.	.	.
cord-336510-qzm9wgde	198	1	in	in	IN
cord-336510-qzm9wgde	198	2	1969	1969	CD
cord-336510-qzm9wgde	198	3	,	,	,
cord-336510-qzm9wgde	198	4	to	to	TO
cord-336510-qzm9wgde	198	5	describe	describe	VB
cord-336510-qzm9wgde	198	6	lymphocyte	lymphocyte	NN
cord-336510-qzm9wgde	198	7	derived	derive	VBN
cord-336510-qzm9wgde	198	8	factors	factor	NNS
cord-336510-qzm9wgde	198	9	,	,	,
cord-336510-qzm9wgde	198	10	and	and	CC
cord-336510-qzm9wgde	198	11	the	the	DT
cord-336510-qzm9wgde	198	12	term	term	NN
cord-336510-qzm9wgde	198	13	monokine	monokine	NNP
cord-336510-qzm9wgde	198	14	was	be	VBD
cord-336510-qzm9wgde	198	15	used	use	VBN
cord-336510-qzm9wgde	198	16	as	as	IN
cord-336510-qzm9wgde	198	17	a	a	DT
cord-336510-qzm9wgde	198	18	description	description	NN
cord-336510-qzm9wgde	198	19	of	of	IN
cord-336510-qzm9wgde	198	20	factors	factor	NNS
cord-336510-qzm9wgde	198	21	coming	come	VBG
cord-336510-qzm9wgde	198	22	from	from	IN
cord-336510-qzm9wgde	198	23	the	the	DT
cord-336510-qzm9wgde	198	24	mononuclear	mononuclear	JJ
cord-336510-qzm9wgde	198	25	phagocyte	phagocyte	NNP
cord-336510-qzm9wgde	198	26	system	system	NN
cord-336510-qzm9wgde	198	27	,	,	,
cord-336510-qzm9wgde	198	28	both	both	DT
cord-336510-qzm9wgde	198	29	acting	act	VBG
cord-336510-qzm9wgde	198	30	on	on	IN
cord-336510-qzm9wgde	198	31	many	many	JJ
cord-336510-qzm9wgde	198	32	cells	cell	NNS
cord-336510-qzm9wgde	198	33	,	,	,
cord-336510-qzm9wgde	198	34	primarily	primarily	RB
cord-336510-qzm9wgde	198	35	leukocytes	leukocyte	NNS
cord-336510-qzm9wgde	198	36	[	[	-LRB-
cord-336510-qzm9wgde	198	37	172	172	CD
cord-336510-qzm9wgde	198	38	]	]	-RRB-
cord-336510-qzm9wgde	198	39	.	.	.
cord-336510-qzm9wgde	199	1	Because	because	IN
cord-336510-qzm9wgde	199	2	of	of	IN
cord-336510-qzm9wgde	199	3	a	a	DT
cord-336510-qzm9wgde	199	4	broader	broad	JJR
cord-336510-qzm9wgde	199	5	view	view	NN
cord-336510-qzm9wgde	199	6	on	on	IN
cord-336510-qzm9wgde	199	7	origin	origin	NN
cord-336510-qzm9wgde	199	8	and	and	CC
cord-336510-qzm9wgde	199	9	function	function	NN
cord-336510-qzm9wgde	199	10	of	of	IN
cord-336510-qzm9wgde	199	11	these	these	DT
cord-336510-qzm9wgde	199	12	factors	factor	NNS
cord-336510-qzm9wgde	199	13	,	,	,
cord-336510-qzm9wgde	199	14	the	the	DT
cord-336510-qzm9wgde	199	15	term	term	NN
cord-336510-qzm9wgde	199	16	cytokine	cytokine	NN
cord-336510-qzm9wgde	199	17	is	be	VBZ
cord-336510-qzm9wgde	199	18	now	now	RB
cord-336510-qzm9wgde	199	19	more	more	RBR
cord-336510-qzm9wgde	199	20	often	often	RB
cord-336510-qzm9wgde	199	21	used	use	VBN
cord-336510-qzm9wgde	199	22	.	.	.
cord-336510-qzm9wgde	200	1	Each	each	DT
cord-336510-qzm9wgde	200	2	cytokine	cytokine	NN
cord-336510-qzm9wgde	200	3	was	be	VBD
cord-336510-qzm9wgde	200	4	originally	originally	RB
cord-336510-qzm9wgde	200	5	named	name	VBN
cord-336510-qzm9wgde	200	6	according	accord	VBG
cord-336510-qzm9wgde	200	7	to	to	IN
cord-336510-qzm9wgde	200	8	biological	biological	JJ
cord-336510-qzm9wgde	200	9	activity	activity	NN
cord-336510-qzm9wgde	200	10	in	in	IN
cord-336510-qzm9wgde	200	11	a	a	DT
cord-336510-qzm9wgde	200	12	functional	functional	JJ
cord-336510-qzm9wgde	200	13	assay	assay	NN
cord-336510-qzm9wgde	200	14	,	,	,
cord-336510-qzm9wgde	200	15	which	which	WDT
cord-336510-qzm9wgde	200	16	often	often	RB
cord-336510-qzm9wgde	200	17	gave	give	VBD
cord-336510-qzm9wgde	200	18	several	several	JJ
cord-336510-qzm9wgde	200	19	different	different	JJ
cord-336510-qzm9wgde	200	20	names	name	NNS
cord-336510-qzm9wgde	200	21	to	to	IN
cord-336510-qzm9wgde	200	22	one	one	CD
cord-336510-qzm9wgde	200	23	cytokine	cytokine	NN
cord-336510-qzm9wgde	200	24	,	,	,
cord-336510-qzm9wgde	200	25	and	and	CC
cord-336510-qzm9wgde	200	26	thus	thus	RB
cord-336510-qzm9wgde	200	27	confusion	confusion	NN
cord-336510-qzm9wgde	200	28	at	at	IN
cord-336510-qzm9wgde	200	29	the	the	DT
cord-336510-qzm9wgde	200	30	molecular	molecular	JJ
cord-336510-qzm9wgde	200	31	level	level	NN
cord-336510-qzm9wgde	200	32	.	.	.
cord-336510-qzm9wgde	201	1	To	to	TO
cord-336510-qzm9wgde	201	2	straighten	straighten	VB
cord-336510-qzm9wgde	201	3	this	this	DT
cord-336510-qzm9wgde	201	4	out	out	RP
cord-336510-qzm9wgde	201	5	,	,	,
cord-336510-qzm9wgde	201	6	a	a	DT
cord-336510-qzm9wgde	201	7	numerical	numerical	JJ
cord-336510-qzm9wgde	201	8	nomenclature	nomenclature	NN
cord-336510-qzm9wgde	201	9	of	of	IN
cord-336510-qzm9wgde	201	10	interleukins	interleukin	NNS
cord-336510-qzm9wgde	201	11	(	(	-LRB-
cord-336510-qzm9wgde	201	12	between	between	IN
cord-336510-qzm9wgde	201	13	leukocytes	leukocyte	NNS
cord-336510-qzm9wgde	201	14	)	)	-RRB-
cord-336510-qzm9wgde	201	15	was	be	VBD
cord-336510-qzm9wgde	201	16	introduced	introduce	VBN
cord-336510-qzm9wgde	201	17	in	in	IN
cord-336510-qzm9wgde	201	18	1979	1979	CD
cord-336510-qzm9wgde	201	19	[	[	-LRB-
cord-336510-qzm9wgde	201	20	173	173	CD
cord-336510-qzm9wgde	201	21	]	]	-RRB-
cord-336510-qzm9wgde	201	22	.	.	.
cord-336510-qzm9wgde	202	1	This	this	DT
cord-336510-qzm9wgde	202	2	numbering	number	VBG
cord-336510-qzm9wgde	202	3	system	system	NN
cord-336510-qzm9wgde	202	4	has	have	VBZ
cord-336510-qzm9wgde	202	5	clarified	clarify	VBN
cord-336510-qzm9wgde	202	6	the	the	DT
cord-336510-qzm9wgde	202	7	field	field	NN
cord-336510-qzm9wgde	202	8	,	,	,
cord-336510-qzm9wgde	202	9	but	but	CC
cord-336510-qzm9wgde	202	10	since	since	IN
cord-336510-qzm9wgde	202	11	it	-PRON-	PRP
cord-336510-qzm9wgde	202	12	has	have	VBZ
cord-336510-qzm9wgde	202	13	no	no	DT
cord-336510-qzm9wgde	202	14	mnemonic	mnemonic	JJ
cord-336510-qzm9wgde	202	15	functional	functional	JJ
cord-336510-qzm9wgde	202	16	anchorage	anchorage	NN
cord-336510-qzm9wgde	202	17	it	-PRON-	PRP
cord-336510-qzm9wgde	202	18	has	have	VBZ
cord-336510-qzm9wgde	202	19	drawn	draw	VBN
cord-336510-qzm9wgde	202	20	critique	critique	NN
cord-336510-qzm9wgde	202	21	since	since	IN
cord-336510-qzm9wgde	202	22	then	then	RB
cord-336510-qzm9wgde	202	23	[	[	-LRB-
cord-336510-qzm9wgde	202	24	174	174	CD
cord-336510-qzm9wgde	202	25	]	]	-RRB-
cord-336510-qzm9wgde	202	26	[	[	-LRB-
cord-336510-qzm9wgde	202	27	175	175	CD
cord-336510-qzm9wgde	202	28	]	]	-RRB-
cord-336510-qzm9wgde	202	29	[	[	-LRB-
cord-336510-qzm9wgde	202	30	176	176	CD
cord-336510-qzm9wgde	202	31	]	]	-RRB-
cord-336510-qzm9wgde	202	32	.	.	.
cord-336510-qzm9wgde	203	1	The	the	DT
cord-336510-qzm9wgde	203	2	cytokines	cytokine	NNS
cord-336510-qzm9wgde	203	3	are	be	VBP
cord-336510-qzm9wgde	203	4	generally	generally	RB
cord-336510-qzm9wgde	203	5	smaller	small	JJR
cord-336510-qzm9wgde	203	6	proteins	protein	NNS
cord-336510-qzm9wgde	203	7	,	,	,
cord-336510-qzm9wgde	204	1	some	some	DT
cord-336510-qzm9wgde	204	2	composed	compose	VBN
cord-336510-qzm9wgde	204	3	of	of	IN
cord-336510-qzm9wgde	204	4	two	two	CD
cord-336510-qzm9wgde	204	5	subunits	subunit	NNS
cord-336510-qzm9wgde	204	6	,	,	,
cord-336510-qzm9wgde	204	7	utilizing	utilize	VBG
cord-336510-qzm9wgde	204	8	specific	specific	JJ
cord-336510-qzm9wgde	204	9	receptors	receptor	NNS
cord-336510-qzm9wgde	204	10	on	on	IN
cord-336510-qzm9wgde	204	11	target	target	NN
cord-336510-qzm9wgde	204	12	cells	cell	NNS
cord-336510-qzm9wgde	204	13	for	for	IN
cord-336510-qzm9wgde	204	14	induction	induction	NN
cord-336510-qzm9wgde	204	15	of	of	IN
cord-336510-qzm9wgde	204	16	their	-PRON-	PRP$
cord-336510-qzm9wgde	204	17	functional	functional	JJ
cord-336510-qzm9wgde	204	18	effects	effect	NNS
cord-336510-qzm9wgde	204	19	.	.	.
cord-336510-qzm9wgde	205	1	They	-PRON-	PRP
cord-336510-qzm9wgde	205	2	are	be	VBP
cord-336510-qzm9wgde	205	3	structurally	structurally	RB
cord-336510-qzm9wgde	205	4	related	relate	VBN
cord-336510-qzm9wgde	205	5	in	in	IN
cord-336510-qzm9wgde	205	6	three	three	CD
cord-336510-qzm9wgde	205	7	families	family	NNS
cord-336510-qzm9wgde	205	8	,	,	,
cord-336510-qzm9wgde	205	9	with	with	IN
cord-336510-qzm9wgde	205	10	the	the	DT
cord-336510-qzm9wgde	205	11	prototypes	prototype	NNS
cord-336510-qzm9wgde	205	12	being	be	VBG
cord-336510-qzm9wgde	205	13	IL-1	IL-1	NNP
cord-336510-qzm9wgde	205	14	,	,	,
cord-336510-qzm9wgde	205	15	IL-2	IL-2	NNP
cord-336510-qzm9wgde	205	16	and	and	CC
cord-336510-qzm9wgde	205	17	IL-17	IL-17	NNP
cord-336510-qzm9wgde	205	18	[	[	-LRB-
cord-336510-qzm9wgde	205	19	176	176	CD
cord-336510-qzm9wgde	205	20	]	]	-RRB-
cord-336510-qzm9wgde	205	21	.	.	.
cord-336510-qzm9wgde	206	1	Functionally	functionally	RB
cord-336510-qzm9wgde	206	2	,	,	,
cord-336510-qzm9wgde	206	3	cytokines	cytokine	NNS
cord-336510-qzm9wgde	206	4	are	be	VBP
cord-336510-qzm9wgde	206	5	highly	highly	RB
cord-336510-qzm9wgde	206	6	potent	potent	JJ
cord-336510-qzm9wgde	206	7	regulatory	regulatory	JJ
cord-336510-qzm9wgde	206	8	proteins	protein	NNS
cord-336510-qzm9wgde	206	9	acting	act	VBG
cord-336510-qzm9wgde	206	10	in	in	IN
cord-336510-qzm9wgde	206	11	a	a	DT
cord-336510-qzm9wgde	206	12	paracrine	paracrine	NN
cord-336510-qzm9wgde	206	13	or	or	CC
cord-336510-qzm9wgde	206	14	autocrine	autocrine	JJ
cord-336510-qzm9wgde	206	15	manner	manner	NN
cord-336510-qzm9wgde	206	16	at	at	IN
cord-336510-qzm9wgde	206	17	picomolar	picomolar	JJ
cord-336510-qzm9wgde	206	18	concentrations	concentration	NNS
cord-336510-qzm9wgde	206	19	[	[	-LRB-
cord-336510-qzm9wgde	206	20	177	177	CD
cord-336510-qzm9wgde	206	21	]	]	-RRB-
cord-336510-qzm9wgde	206	22	.	.	.
cord-336510-qzm9wgde	207	1	The	the	DT
cord-336510-qzm9wgde	207	2	cytokine	cytokine	NN
cord-336510-qzm9wgde	207	3	receptors	receptor	NNS
cord-336510-qzm9wgde	207	4	are	be	VBP
cord-336510-qzm9wgde	207	5	also	also	RB
cord-336510-qzm9wgde	207	6	structurally	structurally	RB
cord-336510-qzm9wgde	207	7	clustered	cluster	VBN
cord-336510-qzm9wgde	207	8	in	in	IN
cord-336510-qzm9wgde	207	9	families	family	NNS
cord-336510-qzm9wgde	207	10	,	,	,
cord-336510-qzm9wgde	207	11	and	and	CC
cord-336510-qzm9wgde	207	12	functionally	functionally	RB
cord-336510-qzm9wgde	207	13	utilize	utilize	VB
cord-336510-qzm9wgde	207	14	a	a	DT
cord-336510-qzm9wgde	207	15	battery	battery	NN
cord-336510-qzm9wgde	207	16	of	of	IN
cord-336510-qzm9wgde	207	17	overlapping	overlap	VBG
cord-336510-qzm9wgde	207	18	kinases	kinase	NNS
cord-336510-qzm9wgde	207	19	and	and	CC
cord-336510-qzm9wgde	207	20	nuclear	nuclear	JJ
cord-336510-qzm9wgde	207	21	binding	binding	NN
cord-336510-qzm9wgde	207	22	proteins	protein	NNS
cord-336510-qzm9wgde	207	23	in	in	IN
cord-336510-qzm9wgde	207	24	their	-PRON-	PRP$
cord-336510-qzm9wgde	207	25	signalling	signal	VBG
cord-336510-qzm9wgde	207	26	pathway	pathway	NN
cord-336510-qzm9wgde	207	27	and	and	CC
cord-336510-qzm9wgde	207	28	thus	thus	RB
cord-336510-qzm9wgde	207	29	have	have	VB
cord-336510-qzm9wgde	207	30	overlapping	overlapping	JJ
cord-336510-qzm9wgde	207	31	functions	function	NNS
cord-336510-qzm9wgde	207	32	[	[	-LRB-
cord-336510-qzm9wgde	207	33	178	178	CD
cord-336510-qzm9wgde	207	34	]	]	-RRB-
cord-336510-qzm9wgde	207	35	.	.	.
cord-336510-qzm9wgde	208	1	The	the	DT
cord-336510-qzm9wgde	208	2	final	final	JJ
cord-336510-qzm9wgde	208	3	functional	functional	JJ
cord-336510-qzm9wgde	208	4	capacity	capacity	NN
cord-336510-qzm9wgde	208	5	of	of	IN
cord-336510-qzm9wgde	208	6	the	the	DT
cord-336510-qzm9wgde	208	7	effector	effector	JJ
cord-336510-qzm9wgde	208	8	cell	cell	NN
cord-336510-qzm9wgde	208	9	thus	thus	RB
cord-336510-qzm9wgde	208	10	reflects	reflect	VBZ
cord-336510-qzm9wgde	208	11	the	the	DT
cord-336510-qzm9wgde	208	12	cytokine	cytokine	NN
cord-336510-qzm9wgde	208	13	environment	environment	NN
cord-336510-qzm9wgde	208	14	experienced	experience	VBN
cord-336510-qzm9wgde	208	15	by	by	IN
cord-336510-qzm9wgde	208	16	the	the	DT
cord-336510-qzm9wgde	208	17	cell	cell	NN
cord-336510-qzm9wgde	208	18	[	[	-LRB-
cord-336510-qzm9wgde	208	19	177	177	CD
cord-336510-qzm9wgde	208	20	]	]	-RRB-
cord-336510-qzm9wgde	208	21	.	.	.
cord-336510-qzm9wgde	209	1	Thus	thus	RB
cord-336510-qzm9wgde	209	2	the	the	DT
cord-336510-qzm9wgde	209	3	cytokines	cytokine	NNS
cord-336510-qzm9wgde	209	4	comprise	comprise	VBP
cord-336510-qzm9wgde	209	5	a	a	DT
cord-336510-qzm9wgde	209	6	network	network	NN
cord-336510-qzm9wgde	209	7	of	of	IN
cord-336510-qzm9wgde	209	8	factors	factor	NNS
cord-336510-qzm9wgde	209	9	inducing	induce	VBG
cord-336510-qzm9wgde	209	10	or	or	CC
cord-336510-qzm9wgde	209	11	inhibiting	inhibit	VBG
cord-336510-qzm9wgde	209	12	each	each	DT
cord-336510-qzm9wgde	209	13	others	other	NNS
cord-336510-qzm9wgde	209	14	secretion	secretion	NN
cord-336510-qzm9wgde	209	15	and	and	CC
cord-336510-qzm9wgde	209	16	function	function	NN
cord-336510-qzm9wgde	209	17	in	in	IN
cord-336510-qzm9wgde	209	18	different	different	JJ
cord-336510-qzm9wgde	209	19	cells	cell	NNS
cord-336510-qzm9wgde	209	20	,	,	,
cord-336510-qzm9wgde	209	21	giving	give	VBG
cord-336510-qzm9wgde	209	22	rise	rise	NN
cord-336510-qzm9wgde	209	23	to	to	IN
cord-336510-qzm9wgde	209	24	a	a	DT
cord-336510-qzm9wgde	209	25	constantly	constantly	RB
cord-336510-qzm9wgde	209	26	floating	float	VBG
cord-336510-qzm9wgde	209	27	landscape	landscape	NN
cord-336510-qzm9wgde	209	28	of	of	IN
cord-336510-qzm9wgde	209	29	a	a	DT
cord-336510-qzm9wgde	209	30	large	large	JJ
cord-336510-qzm9wgde	209	31	array	array	NN
cord-336510-qzm9wgde	209	32	of	of	IN
cord-336510-qzm9wgde	209	33	functional	functional	JJ
cord-336510-qzm9wgde	209	34	capacities	capacity	NNS
cord-336510-qzm9wgde	209	35	[	[	-LRB-
cord-336510-qzm9wgde	209	36	177	177	CD
cord-336510-qzm9wgde	209	37	]	]	-RRB-
cord-336510-qzm9wgde	209	38	.	.	.
cord-336510-qzm9wgde	210	1	In	in	IN
cord-336510-qzm9wgde	210	2	the	the	DT
cord-336510-qzm9wgde	210	3	early	early	JJ
cord-336510-qzm9wgde	210	4	hours	hour	NNS
cord-336510-qzm9wgde	210	5	of	of	IN
cord-336510-qzm9wgde	210	6	a	a	DT
cord-336510-qzm9wgde	210	7	viral	viral	JJ
cord-336510-qzm9wgde	210	8	infection	infection	NN
cord-336510-qzm9wgde	210	9	,	,	,
cord-336510-qzm9wgde	210	10	the	the	DT
cord-336510-qzm9wgde	210	11	cytokines	cytokine	NNS
cord-336510-qzm9wgde	210	12	produced	produce	VBN
cord-336510-qzm9wgde	210	13	by	by	IN
cord-336510-qzm9wgde	210	14	cells	cell	NNS
cord-336510-qzm9wgde	210	15	infected	infect	VBN
cord-336510-qzm9wgde	210	16	or	or	CC
cord-336510-qzm9wgde	210	17	coming	come	VBG
cord-336510-qzm9wgde	210	18	into	into	IN
cord-336510-qzm9wgde	210	19	contact	contact	NN
cord-336510-qzm9wgde	210	20	with	with	IN
cord-336510-qzm9wgde	210	21	viral	viral	JJ
cord-336510-qzm9wgde	210	22	products	product	NNS
cord-336510-qzm9wgde	210	23	are	be	VBP
cord-336510-qzm9wgde	210	24	vital	vital	JJ
cord-336510-qzm9wgde	210	25	in	in	IN
cord-336510-qzm9wgde	210	26	conduction	conduction	NN
cord-336510-qzm9wgde	210	27	of	of	IN
cord-336510-qzm9wgde	210	28	the	the	DT
cord-336510-qzm9wgde	210	29	innate	innate	JJ
cord-336510-qzm9wgde	210	30	immune	immune	JJ
cord-336510-qzm9wgde	210	31	response	response	NN
cord-336510-qzm9wgde	210	32	to	to	IN
cord-336510-qzm9wgde	210	33	the	the	DT
cord-336510-qzm9wgde	210	34	infection	infection	NN
cord-336510-qzm9wgde	210	35	[	[	-LRB-
cord-336510-qzm9wgde	210	36	168	168	CD
cord-336510-qzm9wgde	210	37	,	,	,
cord-336510-qzm9wgde	210	38	179	179	CD
cord-336510-qzm9wgde	210	39	]	]	-RRB-
cord-336510-qzm9wgde	210	40	.	.	.
cord-336510-qzm9wgde	211	1	The	the	DT
cord-336510-qzm9wgde	211	2	interferons	interferon	NNS
cord-336510-qzm9wgde	211	3	(	(	-LRB-
cord-336510-qzm9wgde	211	4	IFNs	ifn	NNS
cord-336510-qzm9wgde	211	5	)	)	-RRB-
cord-336510-qzm9wgde	211	6	were	be	VBD
cord-336510-qzm9wgde	211	7	described	describe	VBN
cord-336510-qzm9wgde	211	8	and	and	CC
cord-336510-qzm9wgde	211	9	named	name	VBN
cord-336510-qzm9wgde	211	10	in	in	IN
cord-336510-qzm9wgde	211	11	1957	1957	CD
cord-336510-qzm9wgde	211	12	by	by	IN
cord-336510-qzm9wgde	211	13	Isaacs	Isaacs	NNP
cord-336510-qzm9wgde	211	14	and	and	CC
cord-336510-qzm9wgde	211	15	Lindenmann	Lindenmann	NNP
cord-336510-qzm9wgde	211	16	[	[	-LRB-
cord-336510-qzm9wgde	211	17	170	170	CD
cord-336510-qzm9wgde	211	18	]	]	-RRB-
cord-336510-qzm9wgde	211	19	,	,	,
cord-336510-qzm9wgde	211	20	who	who	WP
cord-336510-qzm9wgde	211	21	characterized	characterize	VBD
cord-336510-qzm9wgde	211	22	the	the	DT
cord-336510-qzm9wgde	211	23	substances	substance	NNS
cord-336510-qzm9wgde	211	24	involved	involve	VBN
cord-336510-qzm9wgde	211	25	in	in	IN
cord-336510-qzm9wgde	211	26	the	the	DT
cord-336510-qzm9wgde	211	27	previously	previously	RB
cord-336510-qzm9wgde	211	28	described	describe	VBN
cord-336510-qzm9wgde	211	29	interference	interference	NN
cord-336510-qzm9wgde	211	30	of	of	IN
cord-336510-qzm9wgde	211	31	one	one	CD
cord-336510-qzm9wgde	211	32	virus	virus	NN
cord-336510-qzm9wgde	211	33	with	with	IN
cord-336510-qzm9wgde	211	34	the	the	DT
cord-336510-qzm9wgde	211	35	replication	replication	NN
cord-336510-qzm9wgde	211	36	of	of	IN
cord-336510-qzm9wgde	211	37	another	another	DT
cord-336510-qzm9wgde	211	38	unrelated	unrelated	JJ
cord-336510-qzm9wgde	211	39	virus	virus	NN
cord-336510-qzm9wgde	211	40	,	,	,
cord-336510-qzm9wgde	211	41	and	and	CC
cord-336510-qzm9wgde	211	42	the	the	DT
cord-336510-qzm9wgde	211	43	interfering	interfere	VBG
cord-336510-qzm9wgde	211	44	activity	activity	NN
cord-336510-qzm9wgde	211	45	of	of	IN
cord-336510-qzm9wgde	211	46	inactivated	inactivate	VBN
cord-336510-qzm9wgde	211	47	influenza	influenza	NN
cord-336510-qzm9wgde	211	48	virus	virus	NN
cord-336510-qzm9wgde	211	49	with	with	IN
cord-336510-qzm9wgde	211	50	the	the	DT
cord-336510-qzm9wgde	211	51	subsequent	subsequent	JJ
cord-336510-qzm9wgde	211	52	infection	infection	NN
cord-336510-qzm9wgde	211	53	of	of	IN
cord-336510-qzm9wgde	211	54	chorioallantoic	chorioallantoic	NNP
cord-336510-qzm9wgde	211	55	membranes	membrane	NNS
cord-336510-qzm9wgde	211	56	[	[	-LRB-
cord-336510-qzm9wgde	211	57	180	180	CD
cord-336510-qzm9wgde	211	58	]	]	-RRB-
cord-336510-qzm9wgde	211	59	[	[	-LRB-
cord-336510-qzm9wgde	211	60	181	181	CD
cord-336510-qzm9wgde	211	61	]	]	-RRB-
cord-336510-qzm9wgde	211	62	[	[	-LRB-
cord-336510-qzm9wgde	211	63	182	182	CD
cord-336510-qzm9wgde	211	64	]	]	-RRB-
cord-336510-qzm9wgde	211	65	.	.	.
cord-336510-qzm9wgde	212	1	The	the	DT
cord-336510-qzm9wgde	212	2	IFNs	ifn	NNS
cord-336510-qzm9wgde	212	3	were	be	VBD
cord-336510-qzm9wgde	212	4	the	the	DT
cord-336510-qzm9wgde	212	5	first	first	JJ
cord-336510-qzm9wgde	212	6	cytokines	cytokine	NNS
cord-336510-qzm9wgde	212	7	described	describe	VBN
cord-336510-qzm9wgde	212	8	in	in	IN
cord-336510-qzm9wgde	212	9	detail	detail	NN
cord-336510-qzm9wgde	212	10	,	,	,
cord-336510-qzm9wgde	212	11	and	and	CC
cord-336510-qzm9wgde	212	12	thus	thus	RB
cord-336510-qzm9wgde	212	13	provided	provide	VBD
cord-336510-qzm9wgde	212	14	the	the	DT
cord-336510-qzm9wgde	212	15	fundamental	fundamental	JJ
cord-336510-qzm9wgde	212	16	basis	basis	NN
cord-336510-qzm9wgde	212	17	for	for	IN
cord-336510-qzm9wgde	212	18	the	the	DT
cord-336510-qzm9wgde	212	19	understanding	understanding	NN
cord-336510-qzm9wgde	212	20	of	of	IN
cord-336510-qzm9wgde	212	21	the	the	DT
cord-336510-qzm9wgde	212	22	cytokine	cytokine	NN
cord-336510-qzm9wgde	212	23	concept	concept	NN
cord-336510-qzm9wgde	212	24	[	[	-LRB-
cord-336510-qzm9wgde	212	25	183	183	CD
cord-336510-qzm9wgde	212	26	]	]	-RRB-
cord-336510-qzm9wgde	212	27	.	.	.
cord-336510-qzm9wgde	213	1	The	the	DT
cord-336510-qzm9wgde	213	2	IFNs	ifn	NNS
cord-336510-qzm9wgde	213	3	are	be	VBP
cord-336510-qzm9wgde	213	4	divided	divide	VBN
cord-336510-qzm9wgde	213	5	into	into	IN
cord-336510-qzm9wgde	213	6	three	three	CD
cord-336510-qzm9wgde	213	7	major	major	JJ
cord-336510-qzm9wgde	213	8	groups	group	NNS
cord-336510-qzm9wgde	213	9	.	.	.
cord-336510-qzm9wgde	214	1	The	the	DT
cord-336510-qzm9wgde	214	2	two	two	CD
cord-336510-qzm9wgde	214	3	original	original	JJ
cord-336510-qzm9wgde	214	4	groups	group	NNS
cord-336510-qzm9wgde	214	5	of	of	IN
cord-336510-qzm9wgde	214	6	IFNs	ifn	NNS
cord-336510-qzm9wgde	214	7	are	be	VBP
cord-336510-qzm9wgde	214	8	designated	designate	VBN
cord-336510-qzm9wgde	214	9	type	type	NN
cord-336510-qzm9wgde	214	10	I	-PRON-	PRP
cord-336510-qzm9wgde	214	11	and	and	CC
cord-336510-qzm9wgde	214	12	type	type	NN
cord-336510-qzm9wgde	214	13	II	ii	NN
cord-336510-qzm9wgde	214	14	,	,	,
cord-336510-qzm9wgde	214	15	type	type	NN
cord-336510-qzm9wgde	215	1	I	-PRON-	PRP
cord-336510-qzm9wgde	215	2	being	be	VBG
cord-336510-qzm9wgde	215	3	the	the	DT
cord-336510-qzm9wgde	215	4	so	so	RB
cord-336510-qzm9wgde	215	5	called	call	VBN
cord-336510-qzm9wgde	215	6	non	non	JJ
cord-336510-qzm9wgde	215	7	-	-	JJ
cord-336510-qzm9wgde	215	8	immune	immune	JJ
cord-336510-qzm9wgde	215	9	IFN	IFN	NNP
cord-336510-qzm9wgde	215	10	,	,	,
cord-336510-qzm9wgde	215	11	and	and	CC
cord-336510-qzm9wgde	215	12	type	type	NN
cord-336510-qzm9wgde	215	13	II	II	NNP
cord-336510-qzm9wgde	215	14	the	the	DT
cord-336510-qzm9wgde	215	15	immune	immune	JJ
cord-336510-qzm9wgde	215	16	IFN	IFN	NNP
cord-336510-qzm9wgde	215	17	.	.	.
cord-336510-qzm9wgde	216	1	Type	Type	NNP
cord-336510-qzm9wgde	216	2	II	II	NNP
cord-336510-qzm9wgde	216	3	(	(	-LRB-
cord-336510-qzm9wgde	216	4	IFN	IFN	NNP
cord-336510-qzm9wgde	216	5	-	-	HYPH
cord-336510-qzm9wgde	216	6	γ	γ	NNP
cord-336510-qzm9wgde	216	7	)	)	-RRB-
cord-336510-qzm9wgde	216	8	is	be	VBZ
cord-336510-qzm9wgde	216	9	produced	produce	VBN
cord-336510-qzm9wgde	216	10	in	in	IN
cord-336510-qzm9wgde	216	11	high	high	JJ
cord-336510-qzm9wgde	216	12	amounts	amount	NNS
cord-336510-qzm9wgde	216	13	as	as	IN
cord-336510-qzm9wgde	216	14	part	part	NN
cord-336510-qzm9wgde	216	15	of	of	IN
cord-336510-qzm9wgde	216	16	a	a	DT
cord-336510-qzm9wgde	216	17	specific	specific	JJ
cord-336510-qzm9wgde	216	18	immune	immune	JJ
cord-336510-qzm9wgde	216	19	reaction	reaction	NN
cord-336510-qzm9wgde	216	20	,	,	,
cord-336510-qzm9wgde	216	21	whereas	whereas	IN
cord-336510-qzm9wgde	216	22	the	the	DT
cord-336510-qzm9wgde	216	23	type	type	NN
cord-336510-qzm9wgde	216	24	I	-PRON-	PRP
cord-336510-qzm9wgde	216	25	IFNs	ifns	VBP
cord-336510-qzm9wgde	216	26	can	can	MD
cord-336510-qzm9wgde	216	27	be	be	VB
cord-336510-qzm9wgde	216	28	produced	produce	VBN
cord-336510-qzm9wgde	216	29	by	by	IN
cord-336510-qzm9wgde	216	30	many	many	JJ
cord-336510-qzm9wgde	216	31	cell	cell	NN
cord-336510-qzm9wgde	216	32	types	type	NNS
cord-336510-qzm9wgde	216	33	in	in	IN
cord-336510-qzm9wgde	216	34	response	response	NN
cord-336510-qzm9wgde	216	35	to	to	IN
cord-336510-qzm9wgde	216	36	,	,	,
cord-336510-qzm9wgde	216	37	in	in	IN
cord-336510-qzm9wgde	216	38	immunological	immunological	JJ
cord-336510-qzm9wgde	216	39	terms	term	NNS
cord-336510-qzm9wgde	216	40	,	,	,
cord-336510-qzm9wgde	216	41	non	non	JJ
cord-336510-qzm9wgde	216	42	-	-	JJ
cord-336510-qzm9wgde	216	43	spe	spe	JJ
cord-336510-qzm9wgde	216	44	-	-	HYPH
cord-336510-qzm9wgde	216	45	cific	cific	JJ
cord-336510-qzm9wgde	216	46	stimulation	stimulation	NN
cord-336510-qzm9wgde	216	47	.	.	.
cord-336510-qzm9wgde	217	1	The	the	DT
cord-336510-qzm9wgde	217	2	many	many	JJ
cord-336510-qzm9wgde	217	3	functions	function	NNS
cord-336510-qzm9wgde	217	4	of	of	IN
cord-336510-qzm9wgde	217	5	IFNs	ifn	NNS
cord-336510-qzm9wgde	217	6	and	and	CC
cord-336510-qzm9wgde	217	7	the	the	DT
cord-336510-qzm9wgde	217	8	growing	grow	VBG
cord-336510-qzm9wgde	217	9	understanding	understanding	NN
cord-336510-qzm9wgde	217	10	of	of	IN
cord-336510-qzm9wgde	217	11	signalling	signalling	NN
cord-336510-qzm9wgde	217	12	and	and	CC
cord-336510-qzm9wgde	217	13	regulation	regulation	NN
cord-336510-qzm9wgde	217	14	indicate	indicate	VBP
cord-336510-qzm9wgde	217	15	that	that	IN
cord-336510-qzm9wgde	217	16	IFN	IFN	NNP
cord-336510-qzm9wgde	217	17	analogues	analogue	NNS
cord-336510-qzm9wgde	217	18	may	may	MD
cord-336510-qzm9wgde	217	19	play	play	VB
cord-336510-qzm9wgde	217	20	a	a	DT
cord-336510-qzm9wgde	217	21	major	major	JJ
cord-336510-qzm9wgde	217	22	role	role	NN
cord-336510-qzm9wgde	217	23	in	in	IN
cord-336510-qzm9wgde	217	24	the	the	DT
cord-336510-qzm9wgde	217	25	next	next	JJ
cord-336510-qzm9wgde	217	26	generation	generation	NN
cord-336510-qzm9wgde	217	27	of	of	IN
cord-336510-qzm9wgde	217	28	new	new	JJ
cord-336510-qzm9wgde	217	29	antiviral	antiviral	JJ
cord-336510-qzm9wgde	217	30	compounds	compound	NNS
cord-336510-qzm9wgde	217	31	[	[	-LRB-
cord-336510-qzm9wgde	217	32	171	171	CD
cord-336510-qzm9wgde	217	33	]	]	-RRB-
cord-336510-qzm9wgde	217	34	.	.	.
cord-336510-qzm9wgde	218	1	The	the	DT
cord-336510-qzm9wgde	218	2	type	type	NN
cord-336510-qzm9wgde	218	3	I	-PRON-	PRP
cord-336510-qzm9wgde	218	4	IFNs	ifns	VBP
cord-336510-qzm9wgde	218	5	are	be	VBP
cord-336510-qzm9wgde	218	6	a	a	DT
cord-336510-qzm9wgde	218	7	diverse	diverse	JJ
cord-336510-qzm9wgde	218	8	group	group	NN
cord-336510-qzm9wgde	218	9	of	of	IN
cord-336510-qzm9wgde	218	10	cytokines	cytokine	NNS
cord-336510-qzm9wgde	218	11	,	,	,
cord-336510-qzm9wgde	218	12	consisting	consist	VBG
cord-336510-qzm9wgde	218	13	of	of	IN
cord-336510-qzm9wgde	218	14	IFN	IFN	NNP
cord-336510-qzm9wgde	218	15	-	-	HYPH
cord-336510-qzm9wgde	218	16	α	α	NNP
cord-336510-qzm9wgde	218	17	,	,	,
cord-336510-qzm9wgde	218	18	IFN	IFN	NNP
cord-336510-qzm9wgde	218	19	-	-	HYPH
cord-336510-qzm9wgde	218	20	β	β	NNP
cord-336510-qzm9wgde	218	21	,	,	,
cord-336510-qzm9wgde	218	22	IFN	IFN	NNP
cord-336510-qzm9wgde	218	23	-	-	HYPH
cord-336510-qzm9wgde	218	24	ε	ε	NNP
cord-336510-qzm9wgde	218	25	,	,	,
cord-336510-qzm9wgde	218	26	IFN	IFN	NNP
cord-336510-qzm9wgde	218	27	-	-	HYPH
cord-336510-qzm9wgde	218	28	κ	κ	NNP
cord-336510-qzm9wgde	218	29	,	,	,
cord-336510-qzm9wgde	218	30	IFN	IFN	NNP
cord-336510-qzm9wgde	218	31	-	-	HYPH
cord-336510-qzm9wgde	218	32	ω	ω	NNP
cord-336510-qzm9wgde	218	33	,	,	,
cord-336510-qzm9wgde	218	34	IFN	IFN	NNP
cord-336510-qzm9wgde	218	35	-	-	HYPH
cord-336510-qzm9wgde	218	36	δ	δ	NNP
cord-336510-qzm9wgde	218	37	,	,	,
cord-336510-qzm9wgde	218	38	IFN	IFN	NNP
cord-336510-qzm9wgde	218	39	-	-	HYPH
cord-336510-qzm9wgde	218	40	τ	τ	NNP
cord-336510-qzm9wgde	218	41	,	,	,
cord-336510-qzm9wgde	218	42	and	and	CC
cord-336510-qzm9wgde	218	43	IFN	IFN	NNP
cord-336510-qzm9wgde	218	44	-	-	HYPH
cord-336510-qzm9wgde	218	45	ξ	ξ	NNP
cord-336510-qzm9wgde	218	46	/	/	SYM
cord-336510-qzm9wgde	218	47	limitin	limitin	NNP
cord-336510-qzm9wgde	218	48	[	[	-LRB-
cord-336510-qzm9wgde	218	49	171	171	CD
cord-336510-qzm9wgde	218	50	,	,	,
cord-336510-qzm9wgde	218	51	184	184	CD
cord-336510-qzm9wgde	218	52	]	]	-RRB-
cord-336510-qzm9wgde	218	53	.	.	.
cord-336510-qzm9wgde	219	1	The	the	DT
cord-336510-qzm9wgde	219	2	first	first	JJ
cord-336510-qzm9wgde	219	3	five	five	CD
cord-336510-qzm9wgde	219	4	of	of	IN
cord-336510-qzm9wgde	219	5	these	these	DT
cord-336510-qzm9wgde	219	6	are	be	VBP
cord-336510-qzm9wgde	219	7	expressed	express	VBN
cord-336510-qzm9wgde	219	8	in	in	IN
cord-336510-qzm9wgde	219	9	humans	human	NNS
cord-336510-qzm9wgde	219	10	,	,	,
cord-336510-qzm9wgde	219	11	and	and	CC
cord-336510-qzm9wgde	219	12	their	-PRON-	PRP$
cord-336510-qzm9wgde	219	13	relative	relative	JJ
cord-336510-qzm9wgde	219	14	production	production	NN
cord-336510-qzm9wgde	219	15	depends	depend	VBZ
cord-336510-qzm9wgde	219	16	on	on	IN
cord-336510-qzm9wgde	219	17	the	the	DT
cord-336510-qzm9wgde	219	18	stimulus	stimulus	NN
cord-336510-qzm9wgde	219	19	and	and	CC
cord-336510-qzm9wgde	219	20	the	the	DT
cord-336510-qzm9wgde	219	21	cell	cell	NN
cord-336510-qzm9wgde	219	22	type	type	NN
cord-336510-qzm9wgde	219	23	in	in	IN
cord-336510-qzm9wgde	219	24	question	question	NN
cord-336510-qzm9wgde	219	25	.	.	.
cord-336510-qzm9wgde	220	1	The	the	DT
cord-336510-qzm9wgde	220	2	IFN	IFN	NNP
cord-336510-qzm9wgde	220	3	-	-	HYPH
cord-336510-qzm9wgde	220	4	α	α	NNP
cord-336510-qzm9wgde	220	5	family	family	NN
cord-336510-qzm9wgde	220	6	consists	consist	VBZ
cord-336510-qzm9wgde	220	7	of	of	IN
cord-336510-qzm9wgde	220	8	multiple	multiple	JJ
cord-336510-qzm9wgde	220	9	species	specie	NNS
cord-336510-qzm9wgde	220	10	and	and	CC
cord-336510-qzm9wgde	220	11	some	some	DT
cord-336510-qzm9wgde	220	12	of	of	IN
cord-336510-qzm9wgde	220	13	these	these	DT
cord-336510-qzm9wgde	220	14	in	in	IN
cord-336510-qzm9wgde	220	15	different	different	JJ
cord-336510-qzm9wgde	220	16	allelic	allelic	JJ
cord-336510-qzm9wgde	220	17	forms	form	NNS
cord-336510-qzm9wgde	220	18	in	in	IN
cord-336510-qzm9wgde	220	19	both	both	DT
cord-336510-qzm9wgde	220	20	humans	human	NNS
cord-336510-qzm9wgde	220	21	and	and	CC
cord-336510-qzm9wgde	220	22	mice	mouse	NNS
cord-336510-qzm9wgde	220	23	.	.	.
cord-336510-qzm9wgde	221	1	In	in	IN
cord-336510-qzm9wgde	221	2	humans	human	NNS
cord-336510-qzm9wgde	221	3	13	13	CD
cord-336510-qzm9wgde	221	4	IFN	IFN	NNP
cord-336510-qzm9wgde	221	5	-	-	HYPH
cord-336510-qzm9wgde	221	6	α	α	NNP
cord-336510-qzm9wgde	221	7	genes	gene	NNS
cord-336510-qzm9wgde	221	8	and	and	CC
cord-336510-qzm9wgde	221	9	one	one	CD
cord-336510-qzm9wgde	221	10	pseudogene	pseudogene	NN
cord-336510-qzm9wgde	221	11	and	and	CC
cord-336510-qzm9wgde	221	12	in	in	IN
cord-336510-qzm9wgde	221	13	mice	mouse	NNS
cord-336510-qzm9wgde	221	14	14	14	CD
cord-336510-qzm9wgde	221	15	IFN	IFN	NNP
cord-336510-qzm9wgde	221	16	-	-	HYPH
cord-336510-qzm9wgde	221	17	α	α	NNP
cord-336510-qzm9wgde	221	18	genes	gene	NNS
cord-336510-qzm9wgde	221	19	and	and	CC
cord-336510-qzm9wgde	221	20	3	3	CD
cord-336510-qzm9wgde	221	21	pseudogenes	pseudogene	NNS
cord-336510-qzm9wgde	221	22	have	have	VBP
cord-336510-qzm9wgde	221	23	been	be	VBN
cord-336510-qzm9wgde	221	24	identified	identify	VBN
cord-336510-qzm9wgde	221	25	,	,	,
cord-336510-qzm9wgde	221	26	clustering	cluster	VBG
cord-336510-qzm9wgde	221	27	on	on	IN
cord-336510-qzm9wgde	221	28	chromosome	chromosome	NN
cord-336510-qzm9wgde	221	29	4	4	CD
cord-336510-qzm9wgde	221	30	in	in	IN
cord-336510-qzm9wgde	221	31	mouse	mouse	NN
cord-336510-qzm9wgde	221	32	and	and	CC
cord-336510-qzm9wgde	221	33	chromosome	chromosome	NN
cord-336510-qzm9wgde	221	34	9	9	CD
cord-336510-qzm9wgde	221	35	in	in	IN
cord-336510-qzm9wgde	221	36	man	man	NN
cord-336510-qzm9wgde	221	37	[	[	-LRB-
cord-336510-qzm9wgde	221	38	185	185	CD
cord-336510-qzm9wgde	221	39	]	]	-RRB-
cord-336510-qzm9wgde	221	40	.	.	.
cord-336510-qzm9wgde	222	1	The	the	DT
cord-336510-qzm9wgde	222	2	functional	functional	JJ
cord-336510-qzm9wgde	222	3	importance	importance	NN
cord-336510-qzm9wgde	222	4	of	of	IN
cord-336510-qzm9wgde	222	5	such	such	PDT
cord-336510-qzm9wgde	222	6	a	a	DT
cord-336510-qzm9wgde	222	7	diversity	diversity	NN
cord-336510-qzm9wgde	222	8	is	be	VBZ
cord-336510-qzm9wgde	222	9	largely	largely	RB
cord-336510-qzm9wgde	222	10	unknown	unknown	JJ
cord-336510-qzm9wgde	222	11	.	.	.
cord-336510-qzm9wgde	223	1	The	the	DT
cord-336510-qzm9wgde	223	2	subtypes	subtype	NNS
cord-336510-qzm9wgde	223	3	differ	differ	VBP
cord-336510-qzm9wgde	223	4	in	in	IN
cord-336510-qzm9wgde	223	5	potency	potency	NN
cord-336510-qzm9wgde	223	6	and	and	CC
cord-336510-qzm9wgde	223	7	have	have	VBP
cord-336510-qzm9wgde	223	8	previously	previously	RB
cord-336510-qzm9wgde	223	9	been	be	VBN
cord-336510-qzm9wgde	223	10	shown	show	VBN
cord-336510-qzm9wgde	223	11	to	to	TO
cord-336510-qzm9wgde	223	12	vary	vary	VB
cord-336510-qzm9wgde	223	13	in	in	IN
cord-336510-qzm9wgde	223	14	their	-PRON-	PRP$
cord-336510-qzm9wgde	223	15	profile	profile	NN
cord-336510-qzm9wgde	223	16	of	of	IN
cord-336510-qzm9wgde	223	17	activities	activity	NNS
cord-336510-qzm9wgde	223	18	[	[	-LRB-
cord-336510-qzm9wgde	223	19	186	186	CD
cord-336510-qzm9wgde	223	20	,	,	,
cord-336510-qzm9wgde	223	21	187	187	CD
cord-336510-qzm9wgde	223	22	]	]	-RRB-
cord-336510-qzm9wgde	223	23	,	,	,
cord-336510-qzm9wgde	223	24	but	but	CC
cord-336510-qzm9wgde	223	25	new	new	JJ
cord-336510-qzm9wgde	223	26	studies	study	NNS
cord-336510-qzm9wgde	223	27	show	show	VBP
cord-336510-qzm9wgde	223	28	correlation	correlation	NN
cord-336510-qzm9wgde	223	29	between	between	IN
cord-336510-qzm9wgde	223	30	antiproliferative	antiproliferative	JJ
cord-336510-qzm9wgde	223	31	and	and	CC
cord-336510-qzm9wgde	223	32	antiviral	antiviral	JJ
cord-336510-qzm9wgde	223	33	effects	effect	NNS
cord-336510-qzm9wgde	223	34	of	of	IN
cord-336510-qzm9wgde	223	35	various	various	JJ
cord-336510-qzm9wgde	223	36	IFN	IFN	NNP
cord-336510-qzm9wgde	223	37	-	-	HYPH
cord-336510-qzm9wgde	223	38	α	α	NN
cord-336510-qzm9wgde	223	39	species	specie	NNS
cord-336510-qzm9wgde	223	40	[	[	-LRB-
cord-336510-qzm9wgde	223	41	185	185	CD
cord-336510-qzm9wgde	223	42	]	]	-RRB-
cord-336510-qzm9wgde	223	43	.	.	.
cord-336510-qzm9wgde	224	1	Thus	thus	RB
cord-336510-qzm9wgde	224	2	,	,	,
cord-336510-qzm9wgde	224	3	it	-PRON-	PRP
cord-336510-qzm9wgde	224	4	seems	seem	VBZ
cord-336510-qzm9wgde	224	5	that	that	IN
cord-336510-qzm9wgde	224	6	the	the	DT
cord-336510-qzm9wgde	224	7	importance	importance	NN
cord-336510-qzm9wgde	224	8	of	of	IN
cord-336510-qzm9wgde	224	9	the	the	DT
cord-336510-qzm9wgde	224	10	diversity	diversity	NN
cord-336510-qzm9wgde	224	11	could	could	MD
cord-336510-qzm9wgde	224	12	come	come	VB
cord-336510-qzm9wgde	224	13	from	from	IN
cord-336510-qzm9wgde	224	14	varying	vary	VBG
cord-336510-qzm9wgde	224	15	expression	expression	NN
cord-336510-qzm9wgde	224	16	patterns	pattern	NNS
cord-336510-qzm9wgde	224	17	of	of	IN
cord-336510-qzm9wgde	224	18	the	the	DT
cord-336510-qzm9wgde	224	19	different	different	JJ
cord-336510-qzm9wgde	224	20	IFN	IFN	NNP
cord-336510-qzm9wgde	224	21	-	-	HYPH
cord-336510-qzm9wgde	224	22	α	α	NN
cord-336510-qzm9wgde	224	23	species	specie	NNS
cord-336510-qzm9wgde	224	24	.	.	.
cord-336510-qzm9wgde	225	1	Most	Most	JJS
cord-336510-qzm9wgde	225	2	of	of	IN
cord-336510-qzm9wgde	225	3	the	the	DT
cord-336510-qzm9wgde	225	4	α	α	NNP
cord-336510-qzm9wgde	225	5	IFNs	IFNs	NNP
cord-336510-qzm9wgde	225	6	are	be	VBP
cord-336510-qzm9wgde	225	7	N	n	NN
cord-336510-qzm9wgde	225	8	-	-	HYPH
cord-336510-qzm9wgde	225	9	glycosylated	glycosylated	JJ
cord-336510-qzm9wgde	225	10	,	,	,
cord-336510-qzm9wgde	225	11	but	but	CC
cord-336510-qzm9wgde	225	12	glycosylation	glycosylation	NN
cord-336510-qzm9wgde	225	13	does	do	VBZ
cord-336510-qzm9wgde	225	14	not	not	RB
cord-336510-qzm9wgde	225	15	correlate	correlate	VB
cord-336510-qzm9wgde	225	16	with	with	IN
cord-336510-qzm9wgde	225	17	activity	activity	NN
cord-336510-qzm9wgde	225	18	of	of	IN
cord-336510-qzm9wgde	225	19	the	the	DT
cord-336510-qzm9wgde	225	20	molecule	molecule	NN
cord-336510-qzm9wgde	225	21	,	,	,
cord-336510-qzm9wgde	225	22	but	but	CC
cord-336510-qzm9wgde	225	23	rather	rather	RB
cord-336510-qzm9wgde	225	24	with	with	IN
cord-336510-qzm9wgde	225	25	in	in	IN
cord-336510-qzm9wgde	225	26	vivo	vivo	NN
cord-336510-qzm9wgde	225	27	stability	stability	NN
cord-336510-qzm9wgde	225	28	,	,	,
cord-336510-qzm9wgde	225	29	and	and	CC
cord-336510-qzm9wgde	225	30	recombinant	recombinant	JJ
cord-336510-qzm9wgde	225	31	IFNs	ifn	NNS
cord-336510-qzm9wgde	225	32	are	be	VBP
cord-336510-qzm9wgde	225	33	shown	show	VBN
cord-336510-qzm9wgde	225	34	to	to	TO
cord-336510-qzm9wgde	225	35	have	have	VB
cord-336510-qzm9wgde	225	36	activity	activity	NN
cord-336510-qzm9wgde	225	37	comparable	comparable	JJ
cord-336510-qzm9wgde	225	38	with	with	IN
cord-336510-qzm9wgde	225	39	that	that	DT
cord-336510-qzm9wgde	225	40	of	of	IN
cord-336510-qzm9wgde	225	41	the	the	DT
cord-336510-qzm9wgde	225	42	naturally	naturally	RB
cord-336510-qzm9wgde	225	43	produced	produce	VBN
cord-336510-qzm9wgde	225	44	molecules	molecule	NNS
cord-336510-qzm9wgde	225	45	[	[	-LRB-
cord-336510-qzm9wgde	225	46	185	185	CD
cord-336510-qzm9wgde	225	47	,	,	,
cord-336510-qzm9wgde	225	48	188	188	CD
cord-336510-qzm9wgde	225	49	]	]	-RRB-
cord-336510-qzm9wgde	225	50	.	.	.
cord-336510-qzm9wgde	226	1	Only	only	RB
cord-336510-qzm9wgde	226	2	one	one	CD
cord-336510-qzm9wgde	226	3	IFN	IFN	NNP
cord-336510-qzm9wgde	226	4	-	-	HYPH
cord-336510-qzm9wgde	226	5	β	β	NN
cord-336510-qzm9wgde	226	6	species	species	NN
cord-336510-qzm9wgde	226	7	exists	exist	VBZ
cord-336510-qzm9wgde	226	8	,	,	,
cord-336510-qzm9wgde	226	9	coded	code	VBN
cord-336510-qzm9wgde	226	10	by	by	IN
cord-336510-qzm9wgde	226	11	a	a	DT
cord-336510-qzm9wgde	226	12	gene	gene	NN
cord-336510-qzm9wgde	226	13	situated	situate	VBN
cord-336510-qzm9wgde	226	14	in	in	IN
cord-336510-qzm9wgde	226	15	the	the	DT
cord-336510-qzm9wgde	226	16	IFN	IFN	NNP
cord-336510-qzm9wgde	226	17	type	type	NN
cord-336510-qzm9wgde	226	18	I	-PRON-	PRP
cord-336510-qzm9wgde	226	19	cluster	cluster	VBP
cord-336510-qzm9wgde	226	20	on	on	IN
cord-336510-qzm9wgde	226	21	chromosome	chromosome	NN
cord-336510-qzm9wgde	226	22	4	4	CD
cord-336510-qzm9wgde	226	23	in	in	IN
cord-336510-qzm9wgde	226	24	mouse	mouse	NN
cord-336510-qzm9wgde	226	25	and	and	CC
cord-336510-qzm9wgde	226	26	chromosome	chromosome	NN
cord-336510-qzm9wgde	226	27	9	9	CD
cord-336510-qzm9wgde	226	28	in	in	IN
cord-336510-qzm9wgde	226	29	man	man	NN
cord-336510-qzm9wgde	226	30	,	,	,
cord-336510-qzm9wgde	226	31	as	as	IN
cord-336510-qzm9wgde	226	32	described	describe	VBN
cord-336510-qzm9wgde	226	33	above	above	IN
cord-336510-qzm9wgde	226	34	[	[	-LRB-
cord-336510-qzm9wgde	226	35	185	185	CD
cord-336510-qzm9wgde	226	36	]	]	-RRB-
cord-336510-qzm9wgde	226	37	.	.	.
cord-336510-qzm9wgde	227	1	The	the	DT
cord-336510-qzm9wgde	227	2	natural	natural	JJ
cord-336510-qzm9wgde	227	3	IFN	IFN	NNP
cord-336510-qzm9wgde	227	4	-	-	HYPH
cord-336510-qzm9wgde	227	5	α	α	NNP
cord-336510-qzm9wgde	227	6	and	and	CC
cord-336510-qzm9wgde	227	7	-β	-β	NN
cord-336510-qzm9wgde	227	8	have	have	VB
cord-336510-qzm9wgde	227	9	a	a	DT
cord-336510-qzm9wgde	227	10	molecular	molecular	JJ
cord-336510-qzm9wgde	227	11	weight	weight	NN
cord-336510-qzm9wgde	227	12	of	of	IN
cord-336510-qzm9wgde	227	13	19	19	CD
cord-336510-qzm9wgde	227	14	-26	-26	CD
cord-336510-qzm9wgde	227	15	kDa	kDa	NNS
cord-336510-qzm9wgde	227	16	and	and	CC
cord-336510-qzm9wgde	228	1	most	most	JJS
cord-336510-qzm9wgde	228	2	species	specie	NNS
cord-336510-qzm9wgde	228	3	retain	retain	VBP
cord-336510-qzm9wgde	228	4	stability	stability	NN
cord-336510-qzm9wgde	228	5	at	at	IN
cord-336510-qzm9wgde	228	6	pH	pH	NNP
cord-336510-qzm9wgde	228	7	2	2	CD
cord-336510-qzm9wgde	228	8	[	[	-LRB-
cord-336510-qzm9wgde	228	9	189	189	CD
cord-336510-qzm9wgde	228	10	]	]	-RRB-
cord-336510-qzm9wgde	228	11	.	.	.
cord-336510-qzm9wgde	229	1	All	all	DT
cord-336510-qzm9wgde	229	2	type	type	NN
cord-336510-qzm9wgde	229	3	I	-PRON-	PRP
cord-336510-qzm9wgde	229	4	IFNs	ifns	VBP
cord-336510-qzm9wgde	229	5	bind	bind	NN
cord-336510-qzm9wgde	229	6	to	to	IN
cord-336510-qzm9wgde	229	7	one	one	CD
cord-336510-qzm9wgde	229	8	common	common	JJ
cord-336510-qzm9wgde	229	9	receptor	receptor	NN
cord-336510-qzm9wgde	229	10	composed	compose	VBN
cord-336510-qzm9wgde	229	11	of	of	IN
cord-336510-qzm9wgde	229	12	two	two	CD
cord-336510-qzm9wgde	229	13	subunits	subunit	NNS
cord-336510-qzm9wgde	229	14	,	,	,
cord-336510-qzm9wgde	229	15	IFN	IFN	NNP
cord-336510-qzm9wgde	229	16	-	-	HYPH
cord-336510-qzm9wgde	229	17	α	α	NNP
cord-336510-qzm9wgde	229	18	-	-	HYPH
cord-336510-qzm9wgde	229	19	receptor(R)1	receptor(r)1	NN
cord-336510-qzm9wgde	229	20	and	and	CC
cord-336510-qzm9wgde	229	21	IFN	IFN	NNP
cord-336510-qzm9wgde	229	22	-	-	HYPH
cord-336510-qzm9wgde	229	23	αR2	αR2	NNP
cord-336510-qzm9wgde	229	24	.	.	.
cord-336510-qzm9wgde	230	1	The	the	DT
cord-336510-qzm9wgde	230	2	IFNα	IFNα	NNP
cord-336510-qzm9wgde	230	3	/	/	SYM
cord-336510-qzm9wgde	230	4	β	β	NN
cord-336510-qzm9wgde	230	5	receptor	receptor	NN
cord-336510-qzm9wgde	230	6	(	(	-LRB-
cord-336510-qzm9wgde	230	7	IFNAR	IFNAR	NNP
cord-336510-qzm9wgde	230	8	)	)	-RRB-
cord-336510-qzm9wgde	230	9	signal	signal	VB
cord-336510-qzm9wgde	230	10	through	through	IN
cord-336510-qzm9wgde	230	11	the	the	DT
cord-336510-qzm9wgde	230	12	JAK	JAK	NNP
cord-336510-qzm9wgde	230	13	/	/	SYM
cord-336510-qzm9wgde	230	14	STAT	stat	NN
cord-336510-qzm9wgde	230	15	-	-	HYPH
cord-336510-qzm9wgde	230	16	pathway	pathway	NN
cord-336510-qzm9wgde	230	17	by	by	IN
cord-336510-qzm9wgde	230	18	phosphorylation	phosphorylation	NN
cord-336510-qzm9wgde	230	19	of	of	IN
cord-336510-qzm9wgde	230	20	the	the	DT
cord-336510-qzm9wgde	230	21	Janus	Janus	NNP
cord-336510-qzm9wgde	230	22	kinase	kinase	NN
cord-336510-qzm9wgde	230	23	(	(	-LRB-
cord-336510-qzm9wgde	230	24	JAK)1	jak)1	NN
cord-336510-qzm9wgde	230	25	,	,	,
cord-336510-qzm9wgde	230	26	tyrosine	tyrosine	NN
cord-336510-qzm9wgde	230	27	kinase	kinase	NN
cord-336510-qzm9wgde	230	28	(	(	-LRB-
cord-336510-qzm9wgde	230	29	Tyk)2	tyk)2	CD
cord-336510-qzm9wgde	230	30	,	,	,
cord-336510-qzm9wgde	230	31	signal	signal	NN
cord-336510-qzm9wgde	230	32	transducer	transducer	NN
cord-336510-qzm9wgde	230	33	and	and	CC
cord-336510-qzm9wgde	230	34	activator	activator	NN
cord-336510-qzm9wgde	230	35	of	of	IN
cord-336510-qzm9wgde	230	36	transcription	transcription	NN
cord-336510-qzm9wgde	230	37	(	(	-LRB-
cord-336510-qzm9wgde	230	38	STAT)1	stat)1	NN
cord-336510-qzm9wgde	230	39	and	and	CC
cord-336510-qzm9wgde	230	40	STAT2	STAT2	NNS
cord-336510-qzm9wgde	230	41	,	,	,
cord-336510-qzm9wgde	230	42	and	and	CC
cord-336510-qzm9wgde	230	43	induces	induce	VBZ
cord-336510-qzm9wgde	230	44	genes	gene	NNS
cord-336510-qzm9wgde	230	45	with	with	IN
cord-336510-qzm9wgde	230	46	an	an	DT
cord-336510-qzm9wgde	230	47	IFN	IFN	NNP
cord-336510-qzm9wgde	230	48	-	-	HYPH
cord-336510-qzm9wgde	230	49	stimulated	stimulate	VBN
cord-336510-qzm9wgde	230	50	response	response	NN
cord-336510-qzm9wgde	230	51	element	element	NN
cord-336510-qzm9wgde	230	52	(	(	-LRB-
cord-336510-qzm9wgde	230	53	ISRE	ISRE	NNP
cord-336510-qzm9wgde	230	54	)	)	-RRB-
cord-336510-qzm9wgde	230	55	in	in	IN
cord-336510-qzm9wgde	230	56	their	-PRON-	PRP$
cord-336510-qzm9wgde	230	57	promoter	promoter	NN
cord-336510-qzm9wgde	230	58	[	[	-LRB-
cord-336510-qzm9wgde	230	59	171	171	CD
cord-336510-qzm9wgde	230	60	,	,	,
cord-336510-qzm9wgde	230	61	190	190	CD
cord-336510-qzm9wgde	230	62	]	]	-RRB-
cord-336510-qzm9wgde	230	63	.	.	.
cord-336510-qzm9wgde	231	1	Generally	generally	RB
cord-336510-qzm9wgde	231	2	the	the	DT
cord-336510-qzm9wgde	231	3	type	type	NN
cord-336510-qzm9wgde	231	4	I	-PRON-	PRP
cord-336510-qzm9wgde	231	5	IFNs	ifns	VBP
cord-336510-qzm9wgde	231	6	exhibit	exhibit	VBP
cord-336510-qzm9wgde	231	7	a	a	DT
cord-336510-qzm9wgde	231	8	huge	huge	JJ
cord-336510-qzm9wgde	231	9	range	range	NN
cord-336510-qzm9wgde	231	10	of	of	IN
cord-336510-qzm9wgde	231	11	biological	biological	JJ
cord-336510-qzm9wgde	231	12	effects	effect	NNS
cord-336510-qzm9wgde	231	13	,	,	,
cord-336510-qzm9wgde	231	14	such	such	JJ
cord-336510-qzm9wgde	231	15	as	as	IN
cord-336510-qzm9wgde	231	16	antiviral	antiviral	JJ
cord-336510-qzm9wgde	231	17	and	and	CC
cord-336510-qzm9wgde	231	18	antiproliferative	antiproliferative	JJ
cord-336510-qzm9wgde	231	19	effects	effect	NNS
cord-336510-qzm9wgde	231	20	,	,	,
cord-336510-qzm9wgde	231	21	stimulation	stimulation	NN
cord-336510-qzm9wgde	231	22	of	of	IN
cord-336510-qzm9wgde	231	23	immune	immune	JJ
cord-336510-qzm9wgde	231	24	cells	cell	NNS
cord-336510-qzm9wgde	231	25	such	such	JJ
cord-336510-qzm9wgde	231	26	as	as	IN
cord-336510-qzm9wgde	231	27	T	T	NNP
cord-336510-qzm9wgde	231	28	cells	cell	NNS
cord-336510-qzm9wgde	231	29	,	,	,
cord-336510-qzm9wgde	231	30	natural	natural	JJ
cord-336510-qzm9wgde	231	31	killer	killer	NN
cord-336510-qzm9wgde	231	32	(	(	-LRB-
cord-336510-qzm9wgde	231	33	NK	NK	NNP
cord-336510-qzm9wgde	231	34	)	)	-RRB-
cord-336510-qzm9wgde	231	35	cells	cell	NNS
cord-336510-qzm9wgde	231	36	,	,	,
cord-336510-qzm9wgde	231	37	monocytes	monocyte	NNS
cord-336510-qzm9wgde	231	38	,	,	,
cord-336510-qzm9wgde	231	39	macrophages	macrophage	NNS
cord-336510-qzm9wgde	231	40	,	,	,
cord-336510-qzm9wgde	231	41	and	and	CC
cord-336510-qzm9wgde	231	42	dendritic	dendritic	JJ
cord-336510-qzm9wgde	231	43	cells	cell	NNS
cord-336510-qzm9wgde	231	44	,	,	,
cord-336510-qzm9wgde	231	45	increased	increase	VBN
cord-336510-qzm9wgde	231	46	expression	expression	NN
cord-336510-qzm9wgde	231	47	of	of	IN
cord-336510-qzm9wgde	231	48	MHC	MHC	NNP
cord-336510-qzm9wgde	231	49	-	-	HYPH
cord-336510-qzm9wgde	231	50	I	I	NNP
cord-336510-qzm9wgde	231	51	,	,	,
cord-336510-qzm9wgde	231	52	activation	activation	NN
cord-336510-qzm9wgde	231	53	of	of	IN
cord-336510-qzm9wgde	231	54	pro	pro	JJ
cord-336510-qzm9wgde	231	55	-	-	JJ
cord-336510-qzm9wgde	231	56	apoptotic	apoptotic	JJ
cord-336510-qzm9wgde	231	57	genes	gene	NNS
cord-336510-qzm9wgde	231	58	and	and	CC
cord-336510-qzm9wgde	231	59	inhibition	inhibition	NN
cord-336510-qzm9wgde	231	60	of	of	IN
cord-336510-qzm9wgde	231	61	anti	anti	JJ
cord-336510-qzm9wgde	231	62	-	-	JJ
cord-336510-qzm9wgde	231	63	apoptotic	apoptotic	JJ
cord-336510-qzm9wgde	231	64	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	231	65	,	,	,
cord-336510-qzm9wgde	231	66	modulation	modulation	NN
cord-336510-qzm9wgde	231	67	of	of	IN
cord-336510-qzm9wgde	231	68	cellular	cellular	JJ
cord-336510-qzm9wgde	231	69	differentiation	differentiation	NN
cord-336510-qzm9wgde	231	70	,	,	,
cord-336510-qzm9wgde	231	71	and	and	CC
cord-336510-qzm9wgde	231	72	inhibition	inhibition	NN
cord-336510-qzm9wgde	231	73	of	of	IN
cord-336510-qzm9wgde	231	74	angiogenesis	angiogenesis	NN
cord-336510-qzm9wgde	231	75	[	[	-LRB-
cord-336510-qzm9wgde	231	76	171	171	CD
cord-336510-qzm9wgde	231	77	]	]	-RRB-
cord-336510-qzm9wgde	231	78	.	.	.
cord-336510-qzm9wgde	232	1	The	the	DT
cord-336510-qzm9wgde	232	2	newly	newly	RB
cord-336510-qzm9wgde	232	3	discovered	discover	VBN
cord-336510-qzm9wgde	232	4	IFN	IFN	NNP
cord-336510-qzm9wgde	232	5	-	-	HYPH
cord-336510-qzm9wgde	232	6	ξ	ξ	NNP
cord-336510-qzm9wgde	232	7	/	/	SYM
cord-336510-qzm9wgde	232	8	limitin	limitin	NNP
cord-336510-qzm9wgde	232	9	also	also	RB
cord-336510-qzm9wgde	232	10	interacts	interact	VBZ
cord-336510-qzm9wgde	232	11	with	with	IN
cord-336510-qzm9wgde	232	12	the	the	DT
cord-336510-qzm9wgde	232	13	IFN	IFN	NNP
cord-336510-qzm9wgde	232	14	-	-	HYPH
cord-336510-qzm9wgde	232	15	α	α	NNP
cord-336510-qzm9wgde	232	16	/	/	SYM
cord-336510-qzm9wgde	232	17	β	β	NN
cord-336510-qzm9wgde	232	18	receptor	receptor	NN
cord-336510-qzm9wgde	232	19	,	,	,
cord-336510-qzm9wgde	232	20	and	and	CC
cord-336510-qzm9wgde	232	21	is	be	VBZ
cord-336510-qzm9wgde	232	22	regarded	regard	VBN
cord-336510-qzm9wgde	232	23	as	as	IN
cord-336510-qzm9wgde	232	24	a	a	DT
cord-336510-qzm9wgde	232	25	type	type	NN
cord-336510-qzm9wgde	233	1	I	-PRON-	PRP
cord-336510-qzm9wgde	233	2	IFN	IFN	NNP
cord-336510-qzm9wgde	233	3	[	[	-LRB-
cord-336510-qzm9wgde	233	4	184	184	CD
cord-336510-qzm9wgde	233	5	,	,	,
cord-336510-qzm9wgde	233	6	191	191	CD
cord-336510-qzm9wgde	233	7	]	]	-RRB-
cord-336510-qzm9wgde	233	8	.	.	.
cord-336510-qzm9wgde	234	1	Antiviral	antiviral	JJ
cord-336510-qzm9wgde	234	2	activity	activity	NN
cord-336510-qzm9wgde	234	3	of	of	IN
cord-336510-qzm9wgde	234	4	IFN	IFN	NNP
cord-336510-qzm9wgde	234	5	-	-	HYPH
cord-336510-qzm9wgde	234	6	ξ	ξ	NNP
cord-336510-qzm9wgde	234	7	has	have	VBZ
cord-336510-qzm9wgde	234	8	been	be	VBN
cord-336510-qzm9wgde	234	9	shown	show	VBN
cord-336510-qzm9wgde	234	10	against	against	IN
cord-336510-qzm9wgde	234	11	many	many	JJ
cord-336510-qzm9wgde	234	12	viruses	virus	NNS
cord-336510-qzm9wgde	234	13	including	include	VBG
cord-336510-qzm9wgde	234	14	HSV	HSV	NNP
cord-336510-qzm9wgde	234	15	,	,	,
cord-336510-qzm9wgde	234	16	and	and	CC
cord-336510-qzm9wgde	234	17	it	-PRON-	PRP
cord-336510-qzm9wgde	234	18	exhibits	exhibit	VBZ
cord-336510-qzm9wgde	234	19	both	both	CC
cord-336510-qzm9wgde	234	20	immunomodulatory	immunomodulatory	JJ
cord-336510-qzm9wgde	234	21	and	and	CC
cord-336510-qzm9wgde	234	22	anti	anti	JJ
cord-336510-qzm9wgde	234	23	-	-	JJ
cord-336510-qzm9wgde	234	24	tumour	tumour	JJ
cord-336510-qzm9wgde	234	25	effects	effect	NNS
cord-336510-qzm9wgde	234	26	,	,	,
cord-336510-qzm9wgde	234	27	but	but	CC
cord-336510-qzm9wgde	234	28	the	the	DT
cord-336510-qzm9wgde	234	29	lymphosuppressive	lymphosuppressive	JJ
cord-336510-qzm9wgde	234	30	activity	activity	NN
cord-336510-qzm9wgde	234	31	is	be	VBZ
cord-336510-qzm9wgde	234	32	less	less	JJR
cord-336510-qzm9wgde	234	33	than	than	IN
cord-336510-qzm9wgde	234	34	that	that	DT
cord-336510-qzm9wgde	234	35	of	of	IN
cord-336510-qzm9wgde	234	36	IFN	IFN	NNP
cord-336510-qzm9wgde	234	37	-	-	HYPH
cord-336510-qzm9wgde	234	38	α	α	NNP
cord-336510-qzm9wgde	234	39	[	[	-LRB-
cord-336510-qzm9wgde	234	40	184	184	CD
cord-336510-qzm9wgde	234	41	,	,	,
cord-336510-qzm9wgde	234	42	192	192	CD
cord-336510-qzm9wgde	234	43	]	]	-RRB-
cord-336510-qzm9wgde	234	44	.	.	.
cord-336510-qzm9wgde	235	1	A	a	DT
cord-336510-qzm9wgde	235	2	human	human	JJ
cord-336510-qzm9wgde	235	3	homolog	homolog	NN
cord-336510-qzm9wgde	235	4	of	of	IN
cord-336510-qzm9wgde	235	5	IFN	IFN	NNP
cord-336510-qzm9wgde	235	6	-	-	HYPH
cord-336510-qzm9wgde	235	7	ξ	ξ	NNP
cord-336510-qzm9wgde	235	8	could	could	MD
cord-336510-qzm9wgde	235	9	thus	thus	RB
cord-336510-qzm9wgde	235	10	have	have	VB
cord-336510-qzm9wgde	235	11	interesting	interesting	JJ
cord-336510-qzm9wgde	235	12	potential	potential	NN
cord-336510-qzm9wgde	235	13	in	in	IN
cord-336510-qzm9wgde	235	14	the	the	DT
cord-336510-qzm9wgde	235	15	therapy	therapy	NN
cord-336510-qzm9wgde	235	16	of	of	IN
cord-336510-qzm9wgde	235	17	tumours	tumour	NNS
cord-336510-qzm9wgde	235	18	and	and	CC
cord-336510-qzm9wgde	235	19	viral	viral	JJ
cord-336510-qzm9wgde	235	20	infections	infection	NNS
cord-336510-qzm9wgde	235	21	.	.	.
cord-336510-qzm9wgde	236	1	The	the	DT
cord-336510-qzm9wgde	236	2	type	type	NN
cord-336510-qzm9wgde	236	3	II	II	NNP
cord-336510-qzm9wgde	236	4	IFN	IFN	NNP
cord-336510-qzm9wgde	236	5	is	be	VBZ
cord-336510-qzm9wgde	236	6	represented	represent	VBN
cord-336510-qzm9wgde	236	7	by	by	IN
cord-336510-qzm9wgde	236	8	only	only	RB
cord-336510-qzm9wgde	236	9	one	one	CD
cord-336510-qzm9wgde	236	10	member	member	NN
cord-336510-qzm9wgde	236	11	,	,	,
cord-336510-qzm9wgde	236	12	the	the	DT
cord-336510-qzm9wgde	236	13	IFN	IFN	NNP
cord-336510-qzm9wgde	236	14	-	-	HYPH
cord-336510-qzm9wgde	236	15	γ	γ	NNP
cord-336510-qzm9wgde	236	16	[	[	-LRB-
cord-336510-qzm9wgde	236	17	193	193	CD
cord-336510-qzm9wgde	236	18	]	]	-RRB-
cord-336510-qzm9wgde	236	19	.	.	.
cord-336510-qzm9wgde	237	1	Structurally	structurally	RB
cord-336510-qzm9wgde	237	2	,	,	,
cord-336510-qzm9wgde	237	3	IFN	IFN	NNP
cord-336510-qzm9wgde	237	4	-	-	HYPH
cord-336510-qzm9wgde	237	5	γ	γ	NNP
cord-336510-qzm9wgde	237	6	is	be	VBZ
cord-336510-qzm9wgde	237	7	distinct	distinct	JJ
cord-336510-qzm9wgde	237	8	from	from	IN
cord-336510-qzm9wgde	237	9	the	the	DT
cord-336510-qzm9wgde	237	10	type	type	NN
cord-336510-qzm9wgde	237	11	I	-PRON-	PRP
cord-336510-qzm9wgde	237	12	IFNs	ifns	NN
cord-336510-qzm9wgde	237	13	,	,	,
cord-336510-qzm9wgde	237	14	and	and	CC
cord-336510-qzm9wgde	237	15	it	-PRON-	PRP
cord-336510-qzm9wgde	237	16	signals	signal	VBZ
cord-336510-qzm9wgde	237	17	through	through	IN
cord-336510-qzm9wgde	237	18	a	a	DT
cord-336510-qzm9wgde	237	19	different	different	JJ
cord-336510-qzm9wgde	237	20	receptor	receptor	NN
cord-336510-qzm9wgde	237	21	.	.	.
cord-336510-qzm9wgde	238	1	For	for	IN
cord-336510-qzm9wgde	238	2	many	many	JJ
cord-336510-qzm9wgde	238	3	years	year	NNS
cord-336510-qzm9wgde	238	4	IFN	IFN	NNP
cord-336510-qzm9wgde	238	5	-	-	HYPH
cord-336510-qzm9wgde	238	6	γ	γ	NNP
cord-336510-qzm9wgde	238	7	was	be	VBD
cord-336510-qzm9wgde	238	8	thought	think	VBN
cord-336510-qzm9wgde	238	9	only	only	RB
cord-336510-qzm9wgde	238	10	to	to	TO
cord-336510-qzm9wgde	238	11	be	be	VB
cord-336510-qzm9wgde	238	12	expressed	express	VBN
cord-336510-qzm9wgde	238	13	by	by	IN
cord-336510-qzm9wgde	238	14	T	T	NNP
cord-336510-qzm9wgde	238	15	cells	cell	NNS
cord-336510-qzm9wgde	238	16	.	.	.
cord-336510-qzm9wgde	239	1	Later	later	RB
cord-336510-qzm9wgde	239	2	the	the	DT
cord-336510-qzm9wgde	239	3	large	large	JJ
cord-336510-qzm9wgde	239	4	granular	granular	JJ
cord-336510-qzm9wgde	239	5	lymphocytes	lymphocyte	NNS
cord-336510-qzm9wgde	239	6	(	(	-LRB-
cord-336510-qzm9wgde	239	7	NK	NK	NNP
cord-336510-qzm9wgde	239	8	cells	cell	NNS
cord-336510-qzm9wgde	239	9	)	)	-RRB-
cord-336510-qzm9wgde	239	10	were	be	VBD
cord-336510-qzm9wgde	239	11	recognised	recognise	VBN
cord-336510-qzm9wgde	239	12	as	as	IN
cord-336510-qzm9wgde	239	13	important	important	JJ
cord-336510-qzm9wgde	239	14	producers	producer	NNS
cord-336510-qzm9wgde	239	15	by	by	IN
cord-336510-qzm9wgde	239	16	the	the	DT
cord-336510-qzm9wgde	239	17	fact	fact	NN
cord-336510-qzm9wgde	239	18	that	that	IN
cord-336510-qzm9wgde	239	19	Ia	Ia	NNP
cord-336510-qzm9wgde	239	20	-	-	HYPH
cord-336510-qzm9wgde	239	21	antigen	antigen	NNP
cord-336510-qzm9wgde	239	22	(	(	-LRB-
cord-336510-qzm9wgde	239	23	MHC	MHC	NNP
cord-336510-qzm9wgde	239	24	-	-	HYPH
cord-336510-qzm9wgde	239	25	II	II	NNP
cord-336510-qzm9wgde	239	26	)	)	-RRB-
cord-336510-qzm9wgde	239	27	expression	expression	NN
cord-336510-qzm9wgde	239	28	on	on	IN
cord-336510-qzm9wgde	239	29	mouse	mouse	NN
cord-336510-qzm9wgde	239	30	macrophages	macrophage	NNS
cord-336510-qzm9wgde	239	31	could	could	MD
cord-336510-qzm9wgde	239	32	be	be	VB
cord-336510-qzm9wgde	239	33	induced	induce	VBN
cord-336510-qzm9wgde	239	34	by	by	IN
cord-336510-qzm9wgde	239	35	Listeria	Listeria	NNP
cord-336510-qzm9wgde	239	36	monocytogenes	monocytogene	VBZ
cord-336510-qzm9wgde	239	37	infection	infection	NN
cord-336510-qzm9wgde	239	38	in	in	IN
cord-336510-qzm9wgde	239	39	SCID	SCID	NNP
cord-336510-qzm9wgde	239	40	mice	mouse	NNS
cord-336510-qzm9wgde	239	41	lacking	lack	VBG
cord-336510-qzm9wgde	239	42	T	t	NN
cord-336510-qzm9wgde	239	43	cells	cell	NNS
cord-336510-qzm9wgde	239	44	[	[	-LRB-
cord-336510-qzm9wgde	239	45	194	194	CD
cord-336510-qzm9wgde	239	46	]	]	-RRB-
cord-336510-qzm9wgde	239	47	[	[	-LRB-
cord-336510-qzm9wgde	239	48	195	195	CD
cord-336510-qzm9wgde	239	49	]	]	-RRB-
cord-336510-qzm9wgde	239	50	[	[	-LRB-
cord-336510-qzm9wgde	239	51	196	196	CD
cord-336510-qzm9wgde	239	52	]	]	-RRB-
cord-336510-qzm9wgde	239	53	.	.	.
cord-336510-qzm9wgde	240	1	In	in	IN
cord-336510-qzm9wgde	240	2	recent	recent	JJ
cord-336510-qzm9wgde	240	3	years	year	NNS
cord-336510-qzm9wgde	240	4	it	-PRON-	PRP
cord-336510-qzm9wgde	240	5	has	have	VBZ
cord-336510-qzm9wgde	240	6	,	,	,
cord-336510-qzm9wgde	240	7	however	however	RB
cord-336510-qzm9wgde	240	8	,	,	,
cord-336510-qzm9wgde	240	9	been	be	VBN
cord-336510-qzm9wgde	240	10	clear	clear	JJ
cord-336510-qzm9wgde	240	11	that	that	IN
cord-336510-qzm9wgde	240	12	other	other	JJ
cord-336510-qzm9wgde	240	13	cell	cell	NN
cord-336510-qzm9wgde	240	14	types	type	NNS
cord-336510-qzm9wgde	240	15	,	,	,
cord-336510-qzm9wgde	240	16	originally	originally	RB
cord-336510-qzm9wgde	240	17	thought	think	VBD
cord-336510-qzm9wgde	240	18	not	not	RB
cord-336510-qzm9wgde	240	19	to	to	TO
cord-336510-qzm9wgde	240	20	be	be	VB
cord-336510-qzm9wgde	240	21	producers	producer	NNS
cord-336510-qzm9wgde	240	22	of	of	IN
cord-336510-qzm9wgde	240	23	IFN	IFN	NNP
cord-336510-qzm9wgde	240	24	-	-	HYPH
cord-336510-qzm9wgde	240	25	γ	γ	NNP
cord-336510-qzm9wgde	240	26	,	,	,
cord-336510-qzm9wgde	240	27	are	be	VBP
cord-336510-qzm9wgde	240	28	in	in	IN
cord-336510-qzm9wgde	240	29	fact	fact	NN
cord-336510-qzm9wgde	240	30	capable	capable	JJ
cord-336510-qzm9wgde	240	31	of	of	IN
cord-336510-qzm9wgde	240	32	IFN	IFN	NNP
cord-336510-qzm9wgde	240	33	-	-	HYPH
cord-336510-qzm9wgde	240	34	γ	γ	NNP
cord-336510-qzm9wgde	240	35	expression	expression	NN
cord-336510-qzm9wgde	240	36	.	.	.
cord-336510-qzm9wgde	241	1	So	so	RB
cord-336510-qzm9wgde	241	2	now	now	RB
cord-336510-qzm9wgde	241	3	macrophages	macrophage	NNS
cord-336510-qzm9wgde	241	4	,	,	,
cord-336510-qzm9wgde	241	5	B	b	NN
cord-336510-qzm9wgde	241	6	cells	cell	NNS
cord-336510-qzm9wgde	241	7	,	,	,
cord-336510-qzm9wgde	241	8	NKT	NKT	NNP
cord-336510-qzm9wgde	241	9	cells	cell	NNS
cord-336510-qzm9wgde	241	10	and	and	CC
cord-336510-qzm9wgde	241	11	professional	professional	JJ
cord-336510-qzm9wgde	241	12	antigen	antigen	NN
cord-336510-qzm9wgde	241	13	-	-	HYPH
cord-336510-qzm9wgde	241	14	presenting	present	VBG
cord-336510-qzm9wgde	241	15	cells	cell	NNS
cord-336510-qzm9wgde	241	16	are	be	VBP
cord-336510-qzm9wgde	241	17	also	also	RB
cord-336510-qzm9wgde	241	18	recognized	recognize	VBN
cord-336510-qzm9wgde	241	19	as	as	IN
cord-336510-qzm9wgde	241	20	IFNγ	IFNγ	NNS
cord-336510-qzm9wgde	241	21	producers	producer	NNS
cord-336510-qzm9wgde	241	22	in	in	IN
cord-336510-qzm9wgde	241	23	certain	certain	JJ
cord-336510-qzm9wgde	241	24	situations	situation	NNS
cord-336510-qzm9wgde	241	25	[	[	-LRB-
cord-336510-qzm9wgde	241	26	197	197	CD
cord-336510-qzm9wgde	241	27	]	]	-RRB-
cord-336510-qzm9wgde	241	28	[	[	-LRB-
cord-336510-qzm9wgde	241	29	198	198	CD
cord-336510-qzm9wgde	241	30	]	]	-RRB-
cord-336510-qzm9wgde	241	31	[	[	-LRB-
cord-336510-qzm9wgde	241	32	199	199	CD
cord-336510-qzm9wgde	241	33	]	]	-RRB-
cord-336510-qzm9wgde	241	34	[	[	-LRB-
cord-336510-qzm9wgde	241	35	200	200	CD
cord-336510-qzm9wgde	241	36	]	]	-RRB-
cord-336510-qzm9wgde	241	37	[	[	-LRB-
cord-336510-qzm9wgde	241	38	201	201	CD
cord-336510-qzm9wgde	241	39	]	]	-RRB-
cord-336510-qzm9wgde	241	40	[	[	-LRB-
cord-336510-qzm9wgde	241	41	202	202	CD
cord-336510-qzm9wgde	241	42	]	]	-RRB-
cord-336510-qzm9wgde	241	43	.	.	.
cord-336510-qzm9wgde	242	1	Induction	induction	NN
cord-336510-qzm9wgde	242	2	and	and	CC
cord-336510-qzm9wgde	242	3	production	production	NN
cord-336510-qzm9wgde	242	4	of	of	IN
cord-336510-qzm9wgde	242	5	IFN	IFN	NNP
cord-336510-qzm9wgde	242	6	-	-	HYPH
cord-336510-qzm9wgde	242	7	γ	γ	NNP
cord-336510-qzm9wgde	242	8	in	in	IN
cord-336510-qzm9wgde	242	9	antigen	antigen	NN
cord-336510-qzm9wgde	242	10	-	-	HYPH
cord-336510-qzm9wgde	242	11	presenting	present	VBG
cord-336510-qzm9wgde	242	12	cells	cell	NNS
cord-336510-qzm9wgde	242	13	and	and	CC
cord-336510-qzm9wgde	242	14	NK	NK	NNP
cord-336510-qzm9wgde	242	15	cells	cell	NNS
cord-336510-qzm9wgde	242	16	seem	seem	VBP
cord-336510-qzm9wgde	242	17	to	to	TO
cord-336510-qzm9wgde	242	18	be	be	VB
cord-336510-qzm9wgde	242	19	vital	vital	JJ
cord-336510-qzm9wgde	242	20	in	in	IN
cord-336510-qzm9wgde	242	21	the	the	DT
cord-336510-qzm9wgde	242	22	early	early	JJ
cord-336510-qzm9wgde	242	23	non	non	JJ
cord-336510-qzm9wgde	242	24	-	-	JJ
cord-336510-qzm9wgde	242	25	specific	specific	JJ
cord-336510-qzm9wgde	242	26	response	response	NN
cord-336510-qzm9wgde	242	27	to	to	IN
cord-336510-qzm9wgde	242	28	infections	infection	NNS
cord-336510-qzm9wgde	242	29	and	and	CC
cord-336510-qzm9wgde	242	30	of	of	IN
cord-336510-qzm9wgde	242	31	importance	importance	NN
cord-336510-qzm9wgde	242	32	in	in	IN
cord-336510-qzm9wgde	242	33	the	the	DT
cord-336510-qzm9wgde	242	34	linkage	linkage	NN
cord-336510-qzm9wgde	242	35	to	to	IN
cord-336510-qzm9wgde	242	36	the	the	DT
cord-336510-qzm9wgde	242	37	adaptive	adaptive	JJ
cord-336510-qzm9wgde	242	38	specific	specific	JJ
cord-336510-qzm9wgde	242	39	responses	response	NNS
cord-336510-qzm9wgde	242	40	coming	come	VBG
cord-336510-qzm9wgde	242	41	up	up	RP
cord-336510-qzm9wgde	242	42	later	later	RB
cord-336510-qzm9wgde	242	43	[	[	-LRB-
cord-336510-qzm9wgde	242	44	202	202	CD
cord-336510-qzm9wgde	242	45	]	]	-RRB-
cord-336510-qzm9wgde	242	46	[	[	-LRB-
cord-336510-qzm9wgde	242	47	203	203	CD
cord-336510-qzm9wgde	242	48	]	]	-RRB-
cord-336510-qzm9wgde	242	49	[	[	-LRB-
cord-336510-qzm9wgde	242	50	204	204	CD
cord-336510-qzm9wgde	242	51	]	]	-RRB-
cord-336510-qzm9wgde	242	52	.	.	.
cord-336510-qzm9wgde	243	1	The	the	DT
cord-336510-qzm9wgde	243	2	induction	induction	NN
cord-336510-qzm9wgde	243	3	of	of	IN
cord-336510-qzm9wgde	243	4	IFN	IFN	NNP
cord-336510-qzm9wgde	243	5	-	-	HYPH
cord-336510-qzm9wgde	243	6	γ	γ	NNP
cord-336510-qzm9wgde	243	7	production	production	NN
cord-336510-qzm9wgde	243	8	in	in	IN
cord-336510-qzm9wgde	243	9	non	non	JJ
cord-336510-qzm9wgde	243	10	-	-	JJ
cord-336510-qzm9wgde	243	11	T	t	JJ
cord-336510-qzm9wgde	243	12	cells	cell	NNS
cord-336510-qzm9wgde	243	13	(	(	-LRB-
cord-336510-qzm9wgde	243	14	e.g.	e.g.	RB
cord-336510-qzm9wgde	243	15	NK	NK	NNP
cord-336510-qzm9wgde	243	16	cells	cell	NNS
cord-336510-qzm9wgde	243	17	)	)	-RRB-
cord-336510-qzm9wgde	243	18	is	be	VBZ
cord-336510-qzm9wgde	243	19	conducted	conduct	VBN
cord-336510-qzm9wgde	243	20	by	by	IN
cord-336510-qzm9wgde	243	21	cytokines	cytokine	NNS
cord-336510-qzm9wgde	243	22	,	,	,
cord-336510-qzm9wgde	243	23	especially	especially	RB
cord-336510-qzm9wgde	243	24	IL-12	il-12	VB
cord-336510-qzm9wgde	243	25	in	in	IN
cord-336510-qzm9wgde	243	26	synergy	synergy	NN
cord-336510-qzm9wgde	243	27	with	with	IN
cord-336510-qzm9wgde	243	28	other	other	JJ
cord-336510-qzm9wgde	243	29	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	243	30	cytokines	cytokine	NNS
cord-336510-qzm9wgde	243	31	,	,	,
cord-336510-qzm9wgde	243	32	largely	largely	RB
cord-336510-qzm9wgde	243	33	produced	produce	VBN
cord-336510-qzm9wgde	243	34	by	by	IN
cord-336510-qzm9wgde	243	35	mononuclear	mononuclear	JJ
cord-336510-qzm9wgde	243	36	phagocytes	phagocyte	NNS
cord-336510-qzm9wgde	243	37	[	[	-LRB-
cord-336510-qzm9wgde	243	38	205	205	CD
cord-336510-qzm9wgde	243	39	,	,	,
cord-336510-qzm9wgde	243	40	206	206	CD
cord-336510-qzm9wgde	243	41	]	]	-RRB-
cord-336510-qzm9wgde	243	42	.	.	.
cord-336510-qzm9wgde	244	1	IFN	IFN	NNP
cord-336510-qzm9wgde	244	2	-	-	HYPH
cord-336510-qzm9wgde	244	3	γ	γ	NNP
cord-336510-qzm9wgde	244	4	exerts	exert	VBZ
cord-336510-qzm9wgde	244	5	its	-PRON-	PRP$
cord-336510-qzm9wgde	244	6	effects	effect	NNS
cord-336510-qzm9wgde	244	7	through	through	IN
cord-336510-qzm9wgde	244	8	a	a	DT
cord-336510-qzm9wgde	244	9	distinct	distinct	JJ
cord-336510-qzm9wgde	244	10	class	class	NN
cord-336510-qzm9wgde	244	11	II	ii	NN
cord-336510-qzm9wgde	244	12	cytokine	cytokine	NN
cord-336510-qzm9wgde	244	13	receptor	receptor	NN
cord-336510-qzm9wgde	244	14	,	,	,
cord-336510-qzm9wgde	244	15	the	the	DT
cord-336510-qzm9wgde	244	16	IFN	IFN	NNP
cord-336510-qzm9wgde	244	17	-	-	HYPH
cord-336510-qzm9wgde	244	18	γ	γ	NN
cord-336510-qzm9wgde	244	19	receptor	receptor	NN
cord-336510-qzm9wgde	244	20	(	(	-LRB-
cord-336510-qzm9wgde	244	21	IFNGR	IFNGR	NNP
cord-336510-qzm9wgde	244	22	)	)	-RRB-
cord-336510-qzm9wgde	244	23	,	,	,
cord-336510-qzm9wgde	244	24	composed	compose	VBN
cord-336510-qzm9wgde	244	25	of	of	IN
cord-336510-qzm9wgde	244	26	two	two	CD
cord-336510-qzm9wgde	244	27	subunits	subunit	NNS
cord-336510-qzm9wgde	244	28	,	,	,
cord-336510-qzm9wgde	244	29	IFN	IFN	NNP
cord-336510-qzm9wgde	244	30	-	-	HYPH
cord-336510-qzm9wgde	244	31	γR1	γR1	NNP
cord-336510-qzm9wgde	244	32	and	and	CC
cord-336510-qzm9wgde	244	33	IFN	IFN	NNP
cord-336510-qzm9wgde	244	34	-	-	HYPH
cord-336510-qzm9wgde	244	35	γR2	γR2	NNP
cord-336510-qzm9wgde	244	36	.	.	.
cord-336510-qzm9wgde	245	1	Upon	upon	IN
cord-336510-qzm9wgde	245	2	binding	bind	VBG
cord-336510-qzm9wgde	245	3	of	of	IN
cord-336510-qzm9wgde	245	4	a	a	DT
cord-336510-qzm9wgde	245	5	homodimer	homodimer	NN
cord-336510-qzm9wgde	245	6	of	of	IN
cord-336510-qzm9wgde	245	7	IFN	IFN	NNP
cord-336510-qzm9wgde	245	8	-	-	HYPH
cord-336510-qzm9wgde	245	9	γ	γ	NNP
cord-336510-qzm9wgde	245	10	to	to	IN
cord-336510-qzm9wgde	245	11	the	the	DT
cord-336510-qzm9wgde	245	12	receptor	receptor	NN
cord-336510-qzm9wgde	245	13	complex	complex	NN
cord-336510-qzm9wgde	245	14	,	,	,
cord-336510-qzm9wgde	245	15	JAK2	JAK2	NNP
cord-336510-qzm9wgde	245	16	autophosphorylates	autophosphorylate	VBZ
cord-336510-qzm9wgde	245	17	and	and	CC
cord-336510-qzm9wgde	245	18	then	then	RB
cord-336510-qzm9wgde	245	19	transphosphorylates	transphosphorylate	VBZ
cord-336510-qzm9wgde	245	20	JAK1	JAK1	NNP
cord-336510-qzm9wgde	245	21	.	.	.
cord-336510-qzm9wgde	246	1	Activated	activate	VBN
cord-336510-qzm9wgde	246	2	JAK1	JAK1	NNP
cord-336510-qzm9wgde	246	3	in	in	IN
cord-336510-qzm9wgde	246	4	turn	turn	NN
cord-336510-qzm9wgde	246	5	phosphorylates	phosphorylate	VBZ
cord-336510-qzm9wgde	246	6	IFN	IFN	NNP
cord-336510-qzm9wgde	246	7	-	-	HYPH
cord-336510-qzm9wgde	246	8	γR1	γR1	NNP
cord-336510-qzm9wgde	246	9	,	,	,
cord-336510-qzm9wgde	246	10	which	which	WDT
cord-336510-qzm9wgde	246	11	allows	allow	VBZ
cord-336510-qzm9wgde	246	12	binding	binding	NN
cord-336510-qzm9wgde	246	13	of	of	IN
cord-336510-qzm9wgde	246	14	the	the	DT
cord-336510-qzm9wgde	246	15	STAT1	stat1	NN
cord-336510-qzm9wgde	246	16	homodimer	homodimer	JJ
cord-336510-qzm9wgde	246	17	to	to	IN
cord-336510-qzm9wgde	246	18	the	the	DT
cord-336510-qzm9wgde	246	19	receptor	receptor	NN
cord-336510-qzm9wgde	246	20	and	and	CC
cord-336510-qzm9wgde	246	21	subsequent	subsequent	JJ
cord-336510-qzm9wgde	246	22	phosphorylation	phosphorylation	NN
cord-336510-qzm9wgde	246	23	of	of	IN
cord-336510-qzm9wgde	246	24	STAT1	stat1	NN
cord-336510-qzm9wgde	246	25	[	[	-LRB-
cord-336510-qzm9wgde	246	26	204	204	CD
cord-336510-qzm9wgde	246	27	]	]	-RRB-
cord-336510-qzm9wgde	246	28	.	.	.
cord-336510-qzm9wgde	247	1	The	the	DT
cord-336510-qzm9wgde	247	2	IFNGR	IFNGR	NNP
cord-336510-qzm9wgde	247	3	and	and	CC
cord-336510-qzm9wgde	247	4	STAT1	stat1	NN
cord-336510-qzm9wgde	247	5	are	be	VBP
cord-336510-qzm9wgde	247	6	preformed	preform	VBN
cord-336510-qzm9wgde	247	7	as	as	IN
cord-336510-qzm9wgde	247	8	hetero	hetero	NNS
cord-336510-qzm9wgde	247	9	-	-	HYPH
cord-336510-qzm9wgde	247	10	and	and	CC
cord-336510-qzm9wgde	247	11	homo	homo	NN
cord-336510-qzm9wgde	247	12	-	-	HYPH
cord-336510-qzm9wgde	247	13	dimers	dimer	NNS
cord-336510-qzm9wgde	247	14	,	,	,
cord-336510-qzm9wgde	247	15	and	and	CC
cord-336510-qzm9wgde	247	16	upon	upon	IN
cord-336510-qzm9wgde	247	17	receptor	receptor	NN
cord-336510-qzm9wgde	247	18	binding	binding	NN
cord-336510-qzm9wgde	247	19	,	,	,
cord-336510-qzm9wgde	247	20	the	the	DT
cord-336510-qzm9wgde	247	21	IFN	IFN	NNP
cord-336510-qzm9wgde	247	22	-	-	HYPH
cord-336510-qzm9wgde	247	23	γ	γ	NNP
cord-336510-qzm9wgde	247	24	-	-	HYPH
cord-336510-qzm9wgde	247	25	IFN	IFN	NNP
cord-336510-qzm9wgde	247	26	-	-	HYPH
cord-336510-qzm9wgde	247	27	γR1-STAT1	γr1-stat1	JJ
cord-336510-qzm9wgde	247	28	complex	complex	NN
cord-336510-qzm9wgde	247	29	seems	seem	VBZ
cord-336510-qzm9wgde	247	30	to	to	TO
cord-336510-qzm9wgde	247	31	be	be	VB
cord-336510-qzm9wgde	247	32	internalized	internalize	VBN
cord-336510-qzm9wgde	247	33	and	and	CC
cord-336510-qzm9wgde	247	34	translocated	translocate	VBN
cord-336510-qzm9wgde	247	35	to	to	IN
cord-336510-qzm9wgde	247	36	the	the	DT
cord-336510-qzm9wgde	247	37	nucleus	nucleus	NN
cord-336510-qzm9wgde	247	38	,	,	,
cord-336510-qzm9wgde	247	39	where	where	WRB
cord-336510-qzm9wgde	247	40	the	the	DT
cord-336510-qzm9wgde	247	41	activated	activate	VBN
cord-336510-qzm9wgde	247	42	STAT1	stat1	NN
cord-336510-qzm9wgde	247	43	homodimer	homodimer	NN
cord-336510-qzm9wgde	247	44	binds	bind	VBZ
cord-336510-qzm9wgde	247	45	to	to	IN
cord-336510-qzm9wgde	247	46	DNA	dna	NN
cord-336510-qzm9wgde	247	47	at	at	IN
cord-336510-qzm9wgde	247	48	GAS	gas	NN
cord-336510-qzm9wgde	247	49	elements	element	NNS
cord-336510-qzm9wgde	247	50	and	and	CC
cord-336510-qzm9wgde	247	51	induces	induce	VBZ
cord-336510-qzm9wgde	247	52	the	the	DT
cord-336510-qzm9wgde	247	53	first	first	JJ
cord-336510-qzm9wgde	247	54	wave	wave	NN
cord-336510-qzm9wgde	247	55	of	of	IN
cord-336510-qzm9wgde	247	56	responses	response	NNS
cord-336510-qzm9wgde	247	57	[	[	-LRB-
cord-336510-qzm9wgde	247	58	204	204	CD
cord-336510-qzm9wgde	247	59	,	,	,
cord-336510-qzm9wgde	247	60	[	[	-LRB-
cord-336510-qzm9wgde	247	61	207	207	CD
cord-336510-qzm9wgde	247	62	]	]	-RRB-
cord-336510-qzm9wgde	247	63	[	[	-LRB-
cord-336510-qzm9wgde	247	64	208	208	CD
cord-336510-qzm9wgde	247	65	]	]	-RRB-
cord-336510-qzm9wgde	247	66	[	[	-LRB-
cord-336510-qzm9wgde	247	67	209	209	CD
cord-336510-qzm9wgde	247	68	]	]	-RRB-
cord-336510-qzm9wgde	247	69	[	[	-LRB-
cord-336510-qzm9wgde	247	70	210	210	CD
cord-336510-qzm9wgde	247	71	]	]	-RRB-
cord-336510-qzm9wgde	247	72	[	[	-LRB-
cord-336510-qzm9wgde	247	73	211	211	CD
cord-336510-qzm9wgde	247	74	]	]	-RRB-
cord-336510-qzm9wgde	247	75	.	.	.
cord-336510-qzm9wgde	248	1	Many	many	JJ
cord-336510-qzm9wgde	248	2	of	of	IN
cord-336510-qzm9wgde	248	3	these	these	DT
cord-336510-qzm9wgde	248	4	initial	initial	JJ
cord-336510-qzm9wgde	248	5	IFN	IFN	NNP
cord-336510-qzm9wgde	248	6	-	-	HYPH
cord-336510-qzm9wgde	248	7	γ	γ	NNP
cord-336510-qzm9wgde	248	8	induced	induce	VBN
cord-336510-qzm9wgde	248	9	products	product	NNS
cord-336510-qzm9wgde	248	10	are	be	VBP
cord-336510-qzm9wgde	248	11	transcription	transcription	NN
cord-336510-qzm9wgde	248	12	factors	factor	NNS
cord-336510-qzm9wgde	248	13	participating	participate	VBG
cord-336510-qzm9wgde	248	14	in	in	IN
cord-336510-qzm9wgde	248	15	further	further	JJ
cord-336510-qzm9wgde	248	16	regulation	regulation	NN
cord-336510-qzm9wgde	248	17	of	of	IN
cord-336510-qzm9wgde	248	18	the	the	DT
cord-336510-qzm9wgde	248	19	many	many	JJ
cord-336510-qzm9wgde	248	20	IFN	IFN	NNP
cord-336510-qzm9wgde	248	21	-	-	HYPH
cord-336510-qzm9wgde	248	22	induced	induce	VBN
cord-336510-qzm9wgde	248	23	cellular	cellular	JJ
cord-336510-qzm9wgde	248	24	response	response	NN
cord-336510-qzm9wgde	248	25	.	.	.
cord-336510-qzm9wgde	249	1	Among	among	IN
cord-336510-qzm9wgde	249	2	these	these	DT
cord-336510-qzm9wgde	249	3	products	product	NNS
cord-336510-qzm9wgde	249	4	are	be	VBP
cord-336510-qzm9wgde	249	5	the	the	DT
cord-336510-qzm9wgde	249	6	IFN	IFN	NNP
cord-336510-qzm9wgde	249	7	regulatory	regulatory	JJ
cord-336510-qzm9wgde	249	8	factors	factor	NNS
cord-336510-qzm9wgde	249	9	(	(	-LRB-
cord-336510-qzm9wgde	249	10	IRFs	IRFs	NNP
cord-336510-qzm9wgde	249	11	)	)	-RRB-
cord-336510-qzm9wgde	249	12	which	which	WDT
cord-336510-qzm9wgde	249	13	stimulate	stimulate	VBP
cord-336510-qzm9wgde	249	14	or	or	CC
cord-336510-qzm9wgde	249	15	inhibit	inhibit	VBP
cord-336510-qzm9wgde	249	16	transcription	transcription	NN
cord-336510-qzm9wgde	249	17	of	of	IN
cord-336510-qzm9wgde	249	18	genes	gene	NNS
cord-336510-qzm9wgde	249	19	possessing	possess	VBG
cord-336510-qzm9wgde	249	20	an	an	DT
cord-336510-qzm9wgde	249	21	ISRE	ISRE	NNP
cord-336510-qzm9wgde	249	22	in	in	IN
cord-336510-qzm9wgde	249	23	the	the	DT
cord-336510-qzm9wgde	249	24	promoter	promoter	NN
cord-336510-qzm9wgde	249	25	region	region	NN
cord-336510-qzm9wgde	249	26	[	[	-LRB-
cord-336510-qzm9wgde	249	27	204	204	CD
cord-336510-qzm9wgde	249	28	,	,	,
cord-336510-qzm9wgde	249	29	212	212	CD
cord-336510-qzm9wgde	249	30	]	]	-RRB-
cord-336510-qzm9wgde	249	31	.	.	.
cord-336510-qzm9wgde	250	1	For	for	IN
cord-336510-qzm9wgde	250	2	many	many	JJ
cord-336510-qzm9wgde	250	3	years	year	NNS
cord-336510-qzm9wgde	250	4	the	the	DT
cord-336510-qzm9wgde	250	5	key	key	JJ
cord-336510-qzm9wgde	250	6	mediator	mediator	NN
cord-336510-qzm9wgde	250	7	of	of	IN
cord-336510-qzm9wgde	250	8	macrophage	macrophage	NN
cord-336510-qzm9wgde	250	9	activation	activation	NN
cord-336510-qzm9wgde	250	10	during	during	IN
cord-336510-qzm9wgde	250	11	antigen	antigen	NN
cord-336510-qzm9wgde	250	12	-	-	HYPH
cord-336510-qzm9wgde	250	13	induced	induce	VBN
cord-336510-qzm9wgde	250	14	processes	process	NNS
cord-336510-qzm9wgde	250	15	was	be	VBD
cord-336510-qzm9wgde	250	16	recognised	recognise	VBN
cord-336510-qzm9wgde	250	17	as	as	IN
cord-336510-qzm9wgde	250	18	macrophage	macrophage	NN
cord-336510-qzm9wgde	250	19	activating	activate	VBG
cord-336510-qzm9wgde	250	20	factor	factor	NN
cord-336510-qzm9wgde	250	21	(	(	-LRB-
cord-336510-qzm9wgde	250	22	MAF	MAF	NNP
cord-336510-qzm9wgde	250	23	)	)	-RRB-
cord-336510-qzm9wgde	250	24	[	[	-LRB-
cord-336510-qzm9wgde	250	25	213	213	CD
cord-336510-qzm9wgde	250	26	]	]	-RRB-
cord-336510-qzm9wgde	250	27	.	.	.
cord-336510-qzm9wgde	251	1	Only	only	RB
cord-336510-qzm9wgde	251	2	later	later	RB
cord-336510-qzm9wgde	251	3	,	,	,
cord-336510-qzm9wgde	251	4	the	the	DT
cord-336510-qzm9wgde	251	5	crucial	crucial	JJ
cord-336510-qzm9wgde	251	6	importance	importance	NN
cord-336510-qzm9wgde	251	7	of	of	IN
cord-336510-qzm9wgde	251	8	these	these	DT
cord-336510-qzm9wgde	251	9	effects	effect	NNS
cord-336510-qzm9wgde	251	10	was	be	VBD
cord-336510-qzm9wgde	251	11	attributed	attribute	VBN
cord-336510-qzm9wgde	251	12	to	to	IN
cord-336510-qzm9wgde	251	13	IFN	IFN	NNP
cord-336510-qzm9wgde	251	14	-	-	HYPH
cord-336510-qzm9wgde	251	15	γ	γ	NNP
cord-336510-qzm9wgde	251	16	[	[	-LRB-
cord-336510-qzm9wgde	251	17	214	214	CD
cord-336510-qzm9wgde	251	18	,	,	,
cord-336510-qzm9wgde	251	19	215	215	CD
cord-336510-qzm9wgde	251	20	]	]	-RRB-
cord-336510-qzm9wgde	251	21	.	.	.
cord-336510-qzm9wgde	252	1	IFN	IFN	NNP
cord-336510-qzm9wgde	252	2	-	-	HYPH
cord-336510-qzm9wgde	252	3	γ	γ	NNP
cord-336510-qzm9wgde	252	4	has	have	VBZ
cord-336510-qzm9wgde	252	5	antiviral	antiviral	JJ
cord-336510-qzm9wgde	252	6	activity	activity	NN
cord-336510-qzm9wgde	252	7	,	,	,
cord-336510-qzm9wgde	252	8	but	but	CC
cord-336510-qzm9wgde	252	9	the	the	DT
cord-336510-qzm9wgde	252	10	most	most	RBS
cord-336510-qzm9wgde	252	11	important	important	JJ
cord-336510-qzm9wgde	252	12	effects	effect	NNS
cord-336510-qzm9wgde	252	13	of	of	IN
cord-336510-qzm9wgde	252	14	IFN	IFN	NNP
cord-336510-qzm9wgde	252	15	-	-	HYPH
cord-336510-qzm9wgde	252	16	γ	γ	NN
cord-336510-qzm9wgde	252	17	seem	seem	VBP
cord-336510-qzm9wgde	252	18	to	to	TO
cord-336510-qzm9wgde	252	19	be	be	VB
cord-336510-qzm9wgde	252	20	activation	activation	NN
cord-336510-qzm9wgde	252	21	of	of	IN
cord-336510-qzm9wgde	252	22	macro	macro	NN
cord-336510-qzm9wgde	252	23	-	-	HYPH
cord-336510-qzm9wgde	252	24	phages	phage	NNS
cord-336510-qzm9wgde	252	25	,	,	,
cord-336510-qzm9wgde	252	26	antigen	antigen	NN
cord-336510-qzm9wgde	252	27	-	-	HYPH
cord-336510-qzm9wgde	252	28	presenting	present	VBG
cord-336510-qzm9wgde	252	29	cells	cell	NNS
cord-336510-qzm9wgde	252	30	,	,	,
cord-336510-qzm9wgde	252	31	and	and	CC
cord-336510-qzm9wgde	252	32	NK	NK	NNP
cord-336510-qzm9wgde	252	33	cells	cell	NNS
cord-336510-qzm9wgde	252	34	and	and	CC
cord-336510-qzm9wgde	252	35	inhibition	inhibition	NN
cord-336510-qzm9wgde	252	36	of	of	IN
cord-336510-qzm9wgde	252	37	T	t	NN
cord-336510-qzm9wgde	252	38	-	-	HYPH
cord-336510-qzm9wgde	252	39	helper	helper	NN
cord-336510-qzm9wgde	252	40	type	type	NN
cord-336510-qzm9wgde	252	41	2	2	CD
cord-336510-qzm9wgde	252	42	(	(	-LRB-
cord-336510-qzm9wgde	252	43	Th2	th2	CD
cord-336510-qzm9wgde	252	44	)	)	-RRB-
cord-336510-qzm9wgde	252	45	cells	cell	NNS
cord-336510-qzm9wgde	252	46	,	,	,
cord-336510-qzm9wgde	252	47	resulting	result	VBG
cord-336510-qzm9wgde	252	48	in	in	IN
cord-336510-qzm9wgde	252	49	a	a	DT
cord-336510-qzm9wgde	252	50	Th1driven	th1driven	DT
cord-336510-qzm9wgde	252	51	cell	cell	NN
cord-336510-qzm9wgde	252	52	-	-	HYPH
cord-336510-qzm9wgde	252	53	mediated	mediate	VBN
cord-336510-qzm9wgde	252	54	response	response	NN
cord-336510-qzm9wgde	252	55	to	to	IN
cord-336510-qzm9wgde	252	56	infection	infection	NN
cord-336510-qzm9wgde	252	57	[	[	-LRB-
cord-336510-qzm9wgde	252	58	204	204	CD
cord-336510-qzm9wgde	252	59	]	]	-RRB-
cord-336510-qzm9wgde	252	60	.	.	.
cord-336510-qzm9wgde	253	1	Experiments	experiment	NNS
cord-336510-qzm9wgde	253	2	in	in	IN
cord-336510-qzm9wgde	253	3	knock	knock	VB
cord-336510-qzm9wgde	253	4	out	out	RP
cord-336510-qzm9wgde	254	1	(	(	-LRB-
cord-336510-qzm9wgde	254	2	KO	KO	NNP
cord-336510-qzm9wgde	254	3	)	)	-RRB-
cord-336510-qzm9wgde	254	4	mice	mouse	NNS
cord-336510-qzm9wgde	254	5	with	with	IN
cord-336510-qzm9wgde	254	6	deficient	deficient	JJ
cord-336510-qzm9wgde	254	7	IFN	IFN	NNP
cord-336510-qzm9wgde	254	8	-	-	HYPH
cord-336510-qzm9wgde	254	9	γ	γ	NN
cord-336510-qzm9wgde	254	10	,	,	,
cord-336510-qzm9wgde	254	11	IFNGR	IFNGR	NNP
cord-336510-qzm9wgde	254	12	,	,	,
cord-336510-qzm9wgde	254	13	or	or	CC
cord-336510-qzm9wgde	254	14	STAT1	stat1	VB
cord-336510-qzm9wgde	254	15	expression	expression	NN
cord-336510-qzm9wgde	254	16	have	have	VBP
cord-336510-qzm9wgde	254	17	shown	show	VBN
cord-336510-qzm9wgde	254	18	that	that	IN
cord-336510-qzm9wgde	254	19	this	this	DT
cord-336510-qzm9wgde	254	20	system	system	NN
cord-336510-qzm9wgde	254	21	is	be	VBZ
cord-336510-qzm9wgde	254	22	of	of	IN
cord-336510-qzm9wgde	254	23	major	major	JJ
cord-336510-qzm9wgde	254	24	importance	importance	NN
cord-336510-qzm9wgde	254	25	,	,	,
cord-336510-qzm9wgde	254	26	but	but	CC
cord-336510-qzm9wgde	254	27	not	not	RB
cord-336510-qzm9wgde	254	28	vital	vital	JJ
cord-336510-qzm9wgde	254	29	,	,	,
cord-336510-qzm9wgde	254	30	in	in	IN
cord-336510-qzm9wgde	254	31	the	the	DT
cord-336510-qzm9wgde	254	32	host	host	NN
cord-336510-qzm9wgde	254	33	response	response	NN
cord-336510-qzm9wgde	254	34	to	to	IN
cord-336510-qzm9wgde	254	35	viral	viral	JJ
cord-336510-qzm9wgde	254	36	infections	infection	NNS
cord-336510-qzm9wgde	254	37	[	[	-LRB-
cord-336510-qzm9wgde	254	38	216	216	CD
cord-336510-qzm9wgde	254	39	]	]	-RRB-
cord-336510-qzm9wgde	254	40	[	[	-LRB-
cord-336510-qzm9wgde	254	41	217	217	CD
cord-336510-qzm9wgde	254	42	]	]	-RRB-
cord-336510-qzm9wgde	254	43	[	[	-LRB-
cord-336510-qzm9wgde	254	44	218	218	CD
cord-336510-qzm9wgde	254	45	]	]	-RRB-
cord-336510-qzm9wgde	254	46	[	[	-LRB-
cord-336510-qzm9wgde	254	47	219	219	CD
cord-336510-qzm9wgde	254	48	]	]	-RRB-
cord-336510-qzm9wgde	254	49	.	.	.
cord-336510-qzm9wgde	255	1	Besides	besides	IN
cord-336510-qzm9wgde	255	2	the	the	DT
cord-336510-qzm9wgde	255	3	two	two	CD
cord-336510-qzm9wgde	255	4	traditional	traditional	JJ
cord-336510-qzm9wgde	255	5	groups	group	NNS
cord-336510-qzm9wgde	255	6	of	of	IN
cord-336510-qzm9wgde	255	7	IFNs	ifn	NNS
cord-336510-qzm9wgde	255	8	,	,	,
cord-336510-qzm9wgde	255	9	a	a	DT
cord-336510-qzm9wgde	255	10	new	new	JJ
cord-336510-qzm9wgde	255	11	group	group	NN
cord-336510-qzm9wgde	255	12	of	of	IN
cord-336510-qzm9wgde	255	13	IFN	IFN	NNP
cord-336510-qzm9wgde	255	14	-	-	HYPH
cord-336510-qzm9wgde	255	15	like	like	JJ
cord-336510-qzm9wgde	255	16	cytokines	cytokine	NNS
cord-336510-qzm9wgde	255	17	has	have	VBZ
cord-336510-qzm9wgde	255	18	been	be	VBN
cord-336510-qzm9wgde	255	19	described	describe	VBN
cord-336510-qzm9wgde	255	20	in	in	IN
cord-336510-qzm9wgde	255	21	various	various	JJ
cord-336510-qzm9wgde	255	22	species	specie	NNS
cord-336510-qzm9wgde	255	23	and	and	CC
cord-336510-qzm9wgde	255	24	named	name	VBN
cord-336510-qzm9wgde	255	25	IL-28A	IL-28A	NNP
cord-336510-qzm9wgde	255	26	(	(	-LRB-
cord-336510-qzm9wgde	255	27	IFN	IFN	NNP
cord-336510-qzm9wgde	255	28	-	-	HYPH
cord-336510-qzm9wgde	255	29	λ2	λ2	NNP
cord-336510-qzm9wgde	255	30	)	)	-RRB-
cord-336510-qzm9wgde	255	31	,	,	,
cord-336510-qzm9wgde	255	32	IL-28B	IL-28B	NNP
cord-336510-qzm9wgde	255	33	(	(	-LRB-
cord-336510-qzm9wgde	255	34	IFN	IFN	NNP
cord-336510-qzm9wgde	255	35	-	-	HYPH
cord-336510-qzm9wgde	255	36	λ3	λ3	NNP
cord-336510-qzm9wgde	255	37	)	)	-RRB-
cord-336510-qzm9wgde	255	38	,	,	,
cord-336510-qzm9wgde	255	39	and	and	CC
cord-336510-qzm9wgde	255	40	IL-29	IL-29	NNP
cord-336510-qzm9wgde	255	41	(	(	-LRB-
cord-336510-qzm9wgde	255	42	IFN	IFN	NNP
cord-336510-qzm9wgde	255	43	-	-	HYPH
cord-336510-qzm9wgde	255	44	λ1	λ1	NNP
cord-336510-qzm9wgde	255	45	)	)	-RRB-
cord-336510-qzm9wgde	255	46	[	[	-LRB-
cord-336510-qzm9wgde	255	47	171	171	CD
cord-336510-qzm9wgde	255	48	,	,	,
cord-336510-qzm9wgde	255	49	220	220	CD
cord-336510-qzm9wgde	255	50	]	]	-RRB-
cord-336510-qzm9wgde	255	51	.	.	.
cord-336510-qzm9wgde	256	1	These	these	DT
cord-336510-qzm9wgde	256	2	cytokines	cytokine	NNS
cord-336510-qzm9wgde	256	3	are	be	VBP
cord-336510-qzm9wgde	256	4	antiviral	antiviral	JJ
cord-336510-qzm9wgde	256	5	proteins	protein	NNS
cord-336510-qzm9wgde	256	6	interacting	interact	VBG
cord-336510-qzm9wgde	256	7	with	with	IN
cord-336510-qzm9wgde	256	8	a	a	DT
cord-336510-qzm9wgde	256	9	distinct	distinct	JJ
cord-336510-qzm9wgde	256	10	heterodimeric	heterodimeric	JJ
cord-336510-qzm9wgde	256	11	class	class	NN
cord-336510-qzm9wgde	256	12	II	II	NNP
cord-336510-qzm9wgde	256	13	cytokine	cytokine	NN
cord-336510-qzm9wgde	256	14	receptor	receptor	NN
cord-336510-qzm9wgde	256	15	composed	compose	VBN
cord-336510-qzm9wgde	256	16	of	of	IN
cord-336510-qzm9wgde	256	17	IFN	IFN	NNP
cord-336510-qzm9wgde	256	18	-	-	HYPH
cord-336510-qzm9wgde	256	19	λR1	λr1	PRP
cord-336510-qzm9wgde	256	20	and	and	CC
cord-336510-qzm9wgde	256	21	IL-10R2	il-10r2	NN
cord-336510-qzm9wgde	256	22	,	,	,
cord-336510-qzm9wgde	256	23	but	but	CC
cord-336510-qzm9wgde	256	24	sharing	share	VBG
cord-336510-qzm9wgde	256	25	with	with	IN
cord-336510-qzm9wgde	256	26	the	the	DT
cord-336510-qzm9wgde	256	27	type	type	NN
cord-336510-qzm9wgde	256	28	I	-PRON-	PRP
cord-336510-qzm9wgde	256	29	IFNs	ifns	VBP
cord-336510-qzm9wgde	256	30	some	some	DT
cord-336510-qzm9wgde	256	31	intracellular	intracellular	JJ
cord-336510-qzm9wgde	256	32	signalling	signal	VBG
cord-336510-qzm9wgde	256	33	pathways	pathway	NNS
cord-336510-qzm9wgde	256	34	through	through	IN
cord-336510-qzm9wgde	256	35	the	the	DT
cord-336510-qzm9wgde	256	36	ISRE	ISRE	NNP
cord-336510-qzm9wgde	256	37	[	[	-LRB-
cord-336510-qzm9wgde	256	38	221	221	CD
cord-336510-qzm9wgde	256	39	]	]	-RRB-
cord-336510-qzm9wgde	256	40	.	.	.
cord-336510-qzm9wgde	257	1	Thus	thus	RB
cord-336510-qzm9wgde	257	2	,	,	,
cord-336510-qzm9wgde	257	3	they	-PRON-	PRP
cord-336510-qzm9wgde	257	4	have	have	VBP
cord-336510-qzm9wgde	257	5	a	a	DT
cord-336510-qzm9wgde	257	6	largely	largely	RB
cord-336510-qzm9wgde	257	7	similar	similar	JJ
cord-336510-qzm9wgde	257	8	antiviral	antiviral	JJ
cord-336510-qzm9wgde	257	9	effect	effect	NN
cord-336510-qzm9wgde	257	10	as	as	IN
cord-336510-qzm9wgde	257	11	the	the	DT
cord-336510-qzm9wgde	257	12	type	type	NN
cord-336510-qzm9wgde	257	13	I	-PRON-	PRP
cord-336510-qzm9wgde	257	14	IFNs	ifns	VBP
cord-336510-qzm9wgde	257	15	[	[	-LRB-
cord-336510-qzm9wgde	257	16	220	220	CD
cord-336510-qzm9wgde	257	17	]	]	-RRB-
cord-336510-qzm9wgde	257	18	.	.	.
cord-336510-qzm9wgde	258	1	Tumour	tumour	NN
cord-336510-qzm9wgde	258	2	necrosis	necrosis	NN
cord-336510-qzm9wgde	258	3	factor	factor	NN
cord-336510-qzm9wgde	258	4	(	(	-LRB-
cord-336510-qzm9wgde	258	5	TNF	TNF	NNP
cord-336510-qzm9wgde	258	6	,	,	,
cord-336510-qzm9wgde	258	7	former	former	JJ
cord-336510-qzm9wgde	258	8	designated	designate	VBN
cord-336510-qzm9wgde	258	9	TNF	TNF	NNP
cord-336510-qzm9wgde	258	10	-	-	HYPH
cord-336510-qzm9wgde	258	11	α	α	NNP
cord-336510-qzm9wgde	258	12	)	)	-RRB-
cord-336510-qzm9wgde	258	13	and	and	CC
cord-336510-qzm9wgde	258	14	lymphotoxin	lymphotoxin	NNP
cord-336510-qzm9wgde	258	15	(	(	-LRB-
cord-336510-qzm9wgde	258	16	LT	LT	NNP
cord-336510-qzm9wgde	258	17	;	;	:
cord-336510-qzm9wgde	258	18	former	former	JJ
cord-336510-qzm9wgde	258	19	TNF	TNF	NNP
cord-336510-qzm9wgde	258	20	-	-	HYPH
cord-336510-qzm9wgde	258	21	β	β	NNP
cord-336510-qzm9wgde	258	22	)	)	-RRB-
cord-336510-qzm9wgde	258	23	were	be	VBD
cord-336510-qzm9wgde	258	24	for	for	IN
cord-336510-qzm9wgde	258	25	many	many	JJ
cord-336510-qzm9wgde	258	26	years	year	NNS
cord-336510-qzm9wgde	258	27	also	also	RB
cord-336510-qzm9wgde	258	28	known	know	VBN
cord-336510-qzm9wgde	258	29	as	as	IN
cord-336510-qzm9wgde	258	30	cachectin	cachectin	NNS
cord-336510-qzm9wgde	258	31	from	from	IN
cord-336510-qzm9wgde	258	32	their	-PRON-	PRP$
cord-336510-qzm9wgde	258	33	involvement	involvement	NN
cord-336510-qzm9wgde	258	34	in	in	IN
cord-336510-qzm9wgde	258	35	cachexia	cachexia	NN
cord-336510-qzm9wgde	258	36	of	of	IN
cord-336510-qzm9wgde	258	37	cancer	cancer	NN
cord-336510-qzm9wgde	258	38	patients	patient	NNS
cord-336510-qzm9wgde	258	39	[	[	-LRB-
cord-336510-qzm9wgde	258	40	222	222	CD
cord-336510-qzm9wgde	258	41	]	]	-RRB-
cord-336510-qzm9wgde	258	42	.	.	.
cord-336510-qzm9wgde	259	1	TNF	TNF	NNP
cord-336510-qzm9wgde	259	2	is	be	VBZ
cord-336510-qzm9wgde	259	3	a	a	DT
cord-336510-qzm9wgde	259	4	prototype	prototype	NN
cord-336510-qzm9wgde	259	5	and	and	CC
cord-336510-qzm9wgde	259	6	the	the	DT
cord-336510-qzm9wgde	259	7	second	second	JJ
cord-336510-qzm9wgde	259	8	member	member	NN
cord-336510-qzm9wgde	259	9	of	of	IN
cord-336510-qzm9wgde	259	10	the	the	DT
cord-336510-qzm9wgde	259	11	TNF	TNF	NNP
cord-336510-qzm9wgde	259	12	ligand	ligand	NN
cord-336510-qzm9wgde	259	13	superfamily	superfamily	NN
cord-336510-qzm9wgde	259	14	(	(	-LRB-
cord-336510-qzm9wgde	259	15	TNFSF2	TNFSF2	NNP
cord-336510-qzm9wgde	259	16	)	)	-RRB-
cord-336510-qzm9wgde	259	17	,	,	,
cord-336510-qzm9wgde	259	18	now	now	RB
cord-336510-qzm9wgde	259	19	encompassing	encompass	VBG
cord-336510-qzm9wgde	259	20	over	over	IN
cord-336510-qzm9wgde	259	21	40	40	CD
cord-336510-qzm9wgde	259	22	known	know	VBN
cord-336510-qzm9wgde	259	23	signalling	signal	VBG
cord-336510-qzm9wgde	259	24	molecules	molecule	NNS
cord-336510-qzm9wgde	259	25	,	,	,
cord-336510-qzm9wgde	259	26	among	among	IN
cord-336510-qzm9wgde	259	27	which	which	WDT
cord-336510-qzm9wgde	259	28	the	the	DT
cord-336510-qzm9wgde	259	29	LTα	LTα	NNS
cord-336510-qzm9wgde	259	30	,	,	,
cord-336510-qzm9wgde	259	31	LTβ	LTβ	NNS
cord-336510-qzm9wgde	259	32	,	,	,
cord-336510-qzm9wgde	259	33	and	and	CC
cord-336510-qzm9wgde	259	34	LIGHT	light	NN
cord-336510-qzm9wgde	259	35	(	(	-LRB-
cord-336510-qzm9wgde	259	36	LTlike	ltlike	JJ
cord-336510-qzm9wgde	259	37	,	,	,
cord-336510-qzm9wgde	259	38	exhibits	exhibit	VBZ
cord-336510-qzm9wgde	259	39	inducible	inducible	JJ
cord-336510-qzm9wgde	259	40	expression	expression	NN
cord-336510-qzm9wgde	259	41	,	,	,
cord-336510-qzm9wgde	259	42	and	and	CC
cord-336510-qzm9wgde	259	43	competes	compete	VBZ
cord-336510-qzm9wgde	259	44	with	with	IN
cord-336510-qzm9wgde	259	45	HSV	HSV	NNP
cord-336510-qzm9wgde	259	46	glycoprotein	glycoprotein	NN
cord-336510-qzm9wgde	259	47	D	d	NN
cord-336510-qzm9wgde	259	48	for	for	IN
cord-336510-qzm9wgde	259	49	HVEM	HVEM	NNP
cord-336510-qzm9wgde	259	50	,	,	,
cord-336510-qzm9wgde	259	51	a	a	DT
cord-336510-qzm9wgde	259	52	receptor	receptor	NN
cord-336510-qzm9wgde	259	53	expressed	express	VBN
cord-336510-qzm9wgde	259	54	by	by	IN
cord-336510-qzm9wgde	259	55	T	T	NNP
cord-336510-qzm9wgde	259	56	lymphocytes	lymphocyte	NNS
cord-336510-qzm9wgde	259	57	)	)	-RRB-
cord-336510-qzm9wgde	259	58	are	be	VBP
cord-336510-qzm9wgde	259	59	some	some	DT
cord-336510-qzm9wgde	259	60	of	of	IN
cord-336510-qzm9wgde	259	61	the	the	DT
cord-336510-qzm9wgde	259	62	more	more	RBR
cord-336510-qzm9wgde	259	63	prominent	prominent	JJ
cord-336510-qzm9wgde	259	64	ligands	ligand	NNS
cord-336510-qzm9wgde	259	65	[	[	-LRB-
cord-336510-qzm9wgde	259	66	58	58	CD
cord-336510-qzm9wgde	259	67	,	,	,
cord-336510-qzm9wgde	259	68	223	223	CD
cord-336510-qzm9wgde	259	69	]	]	-RRB-
cord-336510-qzm9wgde	259	70	.	.	.
cord-336510-qzm9wgde	260	1	Each	each	DT
cord-336510-qzm9wgde	260	2	member	member	NN
cord-336510-qzm9wgde	260	3	is	be	VBZ
cord-336510-qzm9wgde	260	4	the	the	DT
cord-336510-qzm9wgde	260	5	ligand	ligand	NN
cord-336510-qzm9wgde	260	6	of	of	IN
cord-336510-qzm9wgde	260	7	one	one	CD
cord-336510-qzm9wgde	260	8	or	or	CC
cord-336510-qzm9wgde	260	9	two	two	CD
cord-336510-qzm9wgde	260	10	distinct	distinct	JJ
cord-336510-qzm9wgde	260	11	receptors	receptor	NNS
cord-336510-qzm9wgde	260	12	of	of	IN
cord-336510-qzm9wgde	260	13	the	the	DT
cord-336510-qzm9wgde	260	14	TNF	TNF	NNP
cord-336510-qzm9wgde	260	15	receptor	receptor	NN
cord-336510-qzm9wgde	260	16	family	family	NN
cord-336510-qzm9wgde	260	17	sharing	share	VBG
cord-336510-qzm9wgde	260	18	a	a	DT
cord-336510-qzm9wgde	260	19	high	high	JJ
cord-336510-qzm9wgde	260	20	degree	degree	NN
cord-336510-qzm9wgde	260	21	of	of	IN
cord-336510-qzm9wgde	260	22	homology	homology	NN
cord-336510-qzm9wgde	260	23	.	.	.
cord-336510-qzm9wgde	261	1	The	the	DT
cord-336510-qzm9wgde	261	2	current	current	JJ
cord-336510-qzm9wgde	261	3	nomenclature	nomenclature	NN
cord-336510-qzm9wgde	261	4	of	of	IN
cord-336510-qzm9wgde	261	5	these	these	DT
cord-336510-qzm9wgde	261	6	ligands	ligand	NNS
cord-336510-qzm9wgde	261	7	and	and	CC
cord-336510-qzm9wgde	261	8	receptors	receptor	NNS
cord-336510-qzm9wgde	261	9	has	have	VBZ
cord-336510-qzm9wgde	261	10	now	now	RB
cord-336510-qzm9wgde	261	11	been	be	VBN
cord-336510-qzm9wgde	261	12	gathered	gather	VBN
cord-336510-qzm9wgde	261	13	on	on	IN
cord-336510-qzm9wgde	261	14	the	the	DT
cord-336510-qzm9wgde	261	15	internet	internet	NN
cord-336510-qzm9wgde	261	16	[	[	-LRB-
cord-336510-qzm9wgde	261	17	224	224	CD
cord-336510-qzm9wgde	261	18	]	]	-RRB-
cord-336510-qzm9wgde	261	19	.	.	.
cord-336510-qzm9wgde	262	1	TNF	TNF	NNP
cord-336510-qzm9wgde	262	2	is	be	VBZ
cord-336510-qzm9wgde	262	3	a	a	DT
cord-336510-qzm9wgde	262	4	type	type	NN
cord-336510-qzm9wgde	262	5	II	II	NNP
cord-336510-qzm9wgde	262	6	transmembrane	transmembrane	NN
cord-336510-qzm9wgde	262	7	glycoprotein	glycoprotein	NN
cord-336510-qzm9wgde	262	8	coded	code	VBN
cord-336510-qzm9wgde	262	9	from	from	IN
cord-336510-qzm9wgde	262	10	the	the	DT
cord-336510-qzm9wgde	262	11	human	human	JJ
cord-336510-qzm9wgde	262	12	chromosome	chromosome	NN
cord-336510-qzm9wgde	262	13	6	6	CD
cord-336510-qzm9wgde	262	14	and	and	CC
cord-336510-qzm9wgde	262	15	from	from	IN
cord-336510-qzm9wgde	262	16	chromosome	chromosome	NN
cord-336510-qzm9wgde	262	17	17	17	CD
cord-336510-qzm9wgde	262	18	in	in	IN
cord-336510-qzm9wgde	262	19	mice	mouse	NNS
cord-336510-qzm9wgde	262	20	[	[	-LRB-
cord-336510-qzm9wgde	262	21	223	223	CD
cord-336510-qzm9wgde	262	22	]	]	-RRB-
cord-336510-qzm9wgde	262	23	.	.	.
cord-336510-qzm9wgde	263	1	It	-PRON-	PRP
cord-336510-qzm9wgde	263	2	is	be	VBZ
cord-336510-qzm9wgde	263	3	synthesized	synthesize	VBN
cord-336510-qzm9wgde	263	4	as	as	IN
cord-336510-qzm9wgde	263	5	a	a	DT
cord-336510-qzm9wgde	263	6	26	26	CD
cord-336510-qzm9wgde	263	7	kDa	kDa	NNP
cord-336510-qzm9wgde	263	8	transmembrane	transmembrane	NNP
cord-336510-qzm9wgde	263	9	pro	pro	NNP
cord-336510-qzm9wgde	263	10	-	-	NNP
cord-336510-qzm9wgde	263	11	TNF	TNF	NNP
cord-336510-qzm9wgde	263	12	,	,	,
cord-336510-qzm9wgde	263	13	primarily	primarily	RB
cord-336510-qzm9wgde	263	14	located	locate	VBN
cord-336510-qzm9wgde	263	15	in	in	IN
cord-336510-qzm9wgde	263	16	the	the	DT
cord-336510-qzm9wgde	263	17	membranes	membrane	NNS
cord-336510-qzm9wgde	263	18	of	of	IN
cord-336510-qzm9wgde	263	19	the	the	DT
cord-336510-qzm9wgde	263	20	Golgi	Golgi	NNP
cord-336510-qzm9wgde	263	21	apparatus	apparatus	NN
cord-336510-qzm9wgde	263	22	[	[	-LRB-
cord-336510-qzm9wgde	263	23	225	225	CD
cord-336510-qzm9wgde	263	24	]	]	-RRB-
cord-336510-qzm9wgde	263	25	.	.	.
cord-336510-qzm9wgde	264	1	The	the	DT
cord-336510-qzm9wgde	264	2	pro	pro	JJ
cord-336510-qzm9wgde	264	3	-	-	JJ
cord-336510-qzm9wgde	264	4	TNF	TNF	NNP
cord-336510-qzm9wgde	264	5	is	be	VBZ
cord-336510-qzm9wgde	264	6	cleaved	cleave	VBN
cord-336510-qzm9wgde	264	7	by	by	IN
cord-336510-qzm9wgde	264	8	a	a	DT
cord-336510-qzm9wgde	264	9	metalloprotease	metalloprotease	NN
cord-336510-qzm9wgde	264	10	releasing	release	VBG
cord-336510-qzm9wgde	264	11	the	the	DT
cord-336510-qzm9wgde	264	12	17	17	CD
cord-336510-qzm9wgde	264	13	kDa	kDa	NNS
cord-336510-qzm9wgde	264	14	extracellular	extracellular	JJ
cord-336510-qzm9wgde	264	15	portion	portion	NN
cord-336510-qzm9wgde	264	16	of	of	IN
cord-336510-qzm9wgde	264	17	the	the	DT
cord-336510-qzm9wgde	264	18	molecule	molecule	NN
cord-336510-qzm9wgde	264	19	[	[	-LRB-
cord-336510-qzm9wgde	264	20	222	222	CD
cord-336510-qzm9wgde	264	21	,	,	,
cord-336510-qzm9wgde	264	22	226	226	CD
cord-336510-qzm9wgde	264	23	]	]	-RRB-
cord-336510-qzm9wgde	264	24	.	.	.
cord-336510-qzm9wgde	265	1	Production	production	NN
cord-336510-qzm9wgde	265	2	and	and	CC
cord-336510-qzm9wgde	265	3	release	release	NN
cord-336510-qzm9wgde	265	4	of	of	IN
cord-336510-qzm9wgde	265	5	TNF	TNF	NNP
cord-336510-qzm9wgde	265	6	from	from	IN
cord-336510-qzm9wgde	265	7	the	the	DT
cord-336510-qzm9wgde	265	8	cell	cell	NN
cord-336510-qzm9wgde	265	9	is	be	VBZ
cord-336510-qzm9wgde	265	10	regulated	regulate	VBN
cord-336510-qzm9wgde	265	11	at	at	IN
cord-336510-qzm9wgde	265	12	both	both	CC
cord-336510-qzm9wgde	265	13	the	the	DT
cord-336510-qzm9wgde	265	14	transcriptional	transcriptional	JJ
cord-336510-qzm9wgde	265	15	and	and	CC
cord-336510-qzm9wgde	265	16	translational	translational	JJ
cord-336510-qzm9wgde	265	17	level	level	NN
cord-336510-qzm9wgde	265	18	and	and	CC
cord-336510-qzm9wgde	265	19	by	by	IN
cord-336510-qzm9wgde	265	20	post	post	JJ
cord-336510-qzm9wgde	265	21	translational	translational	JJ
cord-336510-qzm9wgde	265	22	modification	modification	NN
cord-336510-qzm9wgde	265	23	as	as	IN
cord-336510-qzm9wgde	265	24	described	describe	VBN
cord-336510-qzm9wgde	265	25	above	above	IN
cord-336510-qzm9wgde	265	26	[	[	-LRB-
cord-336510-qzm9wgde	265	27	227	227	CD
cord-336510-qzm9wgde	265	28	]	]	-RRB-
cord-336510-qzm9wgde	265	29	.	.	.
cord-336510-qzm9wgde	266	1	During	during	IN
cord-336510-qzm9wgde	266	2	HSV	HSV	NNP
cord-336510-qzm9wgde	266	3	infection	infection	NN
cord-336510-qzm9wgde	266	4	both	both	DT
cord-336510-qzm9wgde	266	5	preand	preand	JJ
cord-336510-qzm9wgde	266	6	post	post	JJ
cord-336510-qzm9wgde	266	7	-	-	JJ
cord-336510-qzm9wgde	266	8	transcriptional	transcriptional	JJ
cord-336510-qzm9wgde	266	9	regulatory	regulatory	JJ
cord-336510-qzm9wgde	266	10	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	266	11	are	be	VBP
cord-336510-qzm9wgde	266	12	involved	involve	VBN
cord-336510-qzm9wgde	266	13	in	in	IN
cord-336510-qzm9wgde	266	14	TNF	TNF	NNP
cord-336510-qzm9wgde	266	15	production	production	NN
cord-336510-qzm9wgde	266	16	[	[	-LRB-
cord-336510-qzm9wgde	266	17	228	228	CD
cord-336510-qzm9wgde	266	18	]	]	-RRB-
cord-336510-qzm9wgde	266	19	.	.	.
cord-336510-qzm9wgde	267	1	TNF	TNF	NNP
cord-336510-qzm9wgde	267	2	is	be	VBZ
cord-336510-qzm9wgde	267	3	produced	produce	VBN
cord-336510-qzm9wgde	267	4	by	by	IN
cord-336510-qzm9wgde	267	5	many	many	JJ
cord-336510-qzm9wgde	267	6	cell	cell	NN
cord-336510-qzm9wgde	267	7	types	type	NNS
cord-336510-qzm9wgde	267	8	of	of	IN
cord-336510-qzm9wgde	267	9	immune	immune	JJ
cord-336510-qzm9wgde	267	10	origin	origin	NN
cord-336510-qzm9wgde	267	11	,	,	,
cord-336510-qzm9wgde	267	12	primarily	primarily	RB
cord-336510-qzm9wgde	267	13	mononuclear	mononuclear	JJ
cord-336510-qzm9wgde	267	14	phagocytes	phagocyte	NNS
cord-336510-qzm9wgde	267	15	,	,	,
cord-336510-qzm9wgde	267	16	neutrophils	neutrophil	NNS
cord-336510-qzm9wgde	267	17	,	,	,
cord-336510-qzm9wgde	267	18	NK	NK	NNP
cord-336510-qzm9wgde	267	19	cells	cell	NNS
cord-336510-qzm9wgde	267	20	and	and	CC
cord-336510-qzm9wgde	267	21	T	t	NN
cord-336510-qzm9wgde	267	22	cells	cell	NNS
cord-336510-qzm9wgde	267	23	,	,	,
cord-336510-qzm9wgde	267	24	and	and	CC
cord-336510-qzm9wgde	267	25	has	have	VBZ
cord-336510-qzm9wgde	267	26	diverse	diverse	JJ
cord-336510-qzm9wgde	267	27	effects	effect	NNS
cord-336510-qzm9wgde	267	28	on	on	IN
cord-336510-qzm9wgde	267	29	different	different	JJ
cord-336510-qzm9wgde	267	30	cells	cell	NNS
cord-336510-qzm9wgde	267	31	[	[	-LRB-
cord-336510-qzm9wgde	267	32	222	222	CD
cord-336510-qzm9wgde	267	33	]	]	-RRB-
cord-336510-qzm9wgde	267	34	.	.	.
cord-336510-qzm9wgde	268	1	Both	both	DT
cord-336510-qzm9wgde	268	2	membrane	membrane	NN
cord-336510-qzm9wgde	268	3	bound	bind	VBN
cord-336510-qzm9wgde	268	4	and	and	CC
cord-336510-qzm9wgde	268	5	soluble	soluble	JJ
cord-336510-qzm9wgde	268	6	TNF	TNF	NNP
cord-336510-qzm9wgde	268	7	interact	interact	VBP
cord-336510-qzm9wgde	268	8	as	as	IN
cord-336510-qzm9wgde	268	9	homotrimers	homotrimer	NNS
cord-336510-qzm9wgde	268	10	with	with	IN
cord-336510-qzm9wgde	268	11	two	two	CD
cord-336510-qzm9wgde	268	12	different	different	JJ
cord-336510-qzm9wgde	268	13	receptors	receptor	NNS
cord-336510-qzm9wgde	268	14	,	,	,
cord-336510-qzm9wgde	268	15	the	the	DT
cord-336510-qzm9wgde	268	16	p55	p55	NN
cord-336510-qzm9wgde	269	1	TNFR1	tnfr1	XX
cord-336510-qzm9wgde	270	1	(	(	-LRB-
cord-336510-qzm9wgde	270	2	TNFRSF1A	TNFRSF1A	NNP
cord-336510-qzm9wgde	270	3	)	)	-RRB-
cord-336510-qzm9wgde	270	4	and	and	CC
cord-336510-qzm9wgde	270	5	the	the	DT
cord-336510-qzm9wgde	270	6	p75	p75	CD
cord-336510-qzm9wgde	270	7	TNFR2	tnfr2	NN
cord-336510-qzm9wgde	271	1	(	(	-LRB-
cord-336510-qzm9wgde	271	2	TNFRSF1B	tnfrsf1b	NN
cord-336510-qzm9wgde	271	3	)	)	-RRB-
cord-336510-qzm9wgde	272	1	[	[	-LRB-
cord-336510-qzm9wgde	272	2	222	222	CD
cord-336510-qzm9wgde	272	3	]	]	-RRB-
cord-336510-qzm9wgde	272	4	.	.	.
cord-336510-qzm9wgde	273	1	As	as	IN
cord-336510-qzm9wgde	273	2	most	most	JJS
cord-336510-qzm9wgde	273	3	other	other	JJ
cord-336510-qzm9wgde	273	4	receptors	receptor	NNS
cord-336510-qzm9wgde	273	5	of	of	IN
cord-336510-qzm9wgde	273	6	this	this	DT
cord-336510-qzm9wgde	273	7	family	family	NN
cord-336510-qzm9wgde	273	8	,	,	,
cord-336510-qzm9wgde	273	9	TNFR1	TNFR1	NNP
cord-336510-qzm9wgde	273	10	holds	hold	VBZ
cord-336510-qzm9wgde	273	11	a	a	DT
cord-336510-qzm9wgde	273	12	death	death	NN
cord-336510-qzm9wgde	273	13	domain	domain	NN
cord-336510-qzm9wgde	273	14	important	important	JJ
cord-336510-qzm9wgde	273	15	in	in	IN
cord-336510-qzm9wgde	273	16	the	the	DT
cord-336510-qzm9wgde	273	17	pro	pro	JJ
cord-336510-qzm9wgde	273	18	-	-	JJ
cord-336510-qzm9wgde	273	19	apoptotic	apoptotic	JJ
cord-336510-qzm9wgde	273	20	pathway	pathway	NN
cord-336510-qzm9wgde	273	21	.	.	.
cord-336510-qzm9wgde	274	1	TNFR1	TNFR1	NNP
cord-336510-qzm9wgde	274	2	is	be	VBZ
cord-336510-qzm9wgde	274	3	expressed	express	VBN
cord-336510-qzm9wgde	274	4	virtually	virtually	RB
cord-336510-qzm9wgde	274	5	on	on	IN
cord-336510-qzm9wgde	274	6	every	every	DT
cord-336510-qzm9wgde	274	7	cell	cell	NN
cord-336510-qzm9wgde	274	8	type	type	NN
cord-336510-qzm9wgde	274	9	except	except	IN
cord-336510-qzm9wgde	274	10	erythrocytes	erythrocyte	NNS
cord-336510-qzm9wgde	274	11	,	,	,
cord-336510-qzm9wgde	274	12	whereas	whereas	IN
cord-336510-qzm9wgde	274	13	TNFR2	TNFR2	NNP
cord-336510-qzm9wgde	274	14	is	be	VBZ
cord-336510-qzm9wgde	274	15	mostly	mostly	RB
cord-336510-qzm9wgde	274	16	expressed	express	VBN
cord-336510-qzm9wgde	274	17	on	on	IN
cord-336510-qzm9wgde	274	18	endothelial	endothelial	JJ
cord-336510-qzm9wgde	274	19	and	and	CC
cord-336510-qzm9wgde	274	20	bone	bone	NN
cord-336510-qzm9wgde	274	21	marrow	marrow	NN
cord-336510-qzm9wgde	274	22	derived	derive	VBN
cord-336510-qzm9wgde	274	23	cells	cell	NNS
cord-336510-qzm9wgde	274	24	[	[	-LRB-
cord-336510-qzm9wgde	274	25	227	227	CD
cord-336510-qzm9wgde	274	26	]	]	-RRB-
cord-336510-qzm9wgde	274	27	.	.	.
cord-336510-qzm9wgde	275	1	The	the	DT
cord-336510-qzm9wgde	275	2	TNFR2	tnfr2	NN
cord-336510-qzm9wgde	275	3	activates	activate	VBZ
cord-336510-qzm9wgde	275	4	NF	NF	NNP
cord-336510-qzm9wgde	275	5	-	-	HYPH
cord-336510-qzm9wgde	275	6	κB	κB	NNP
cord-336510-qzm9wgde	275	7	(	(	-LRB-
cord-336510-qzm9wgde	275	8	p50	p50	NN
cord-336510-qzm9wgde	275	9	,	,	,
cord-336510-qzm9wgde	275	10	p65	p65	NN
cord-336510-qzm9wgde	275	11	/	/	SYM
cord-336510-qzm9wgde	275	12	RelA	RelA	NNP
cord-336510-qzm9wgde	275	13	,	,	,
cord-336510-qzm9wgde	275	14	and	and	CC
cord-336510-qzm9wgde	275	15	p52	p52	NN
cord-336510-qzm9wgde	275	16	/	/	SYM
cord-336510-qzm9wgde	275	17	RelB	relb	NN
cord-336510-qzm9wgde	275	18	)	)	-RRB-
cord-336510-qzm9wgde	275	19	by	by	IN
cord-336510-qzm9wgde	275	20	ubiquitin	ubiquitin	NN
cord-336510-qzm9wgde	275	21	-	-	HYPH
cord-336510-qzm9wgde	275	22	mediated	mediate	VBN
cord-336510-qzm9wgde	275	23	degradation	degradation	NN
cord-336510-qzm9wgde	275	24	of	of	IN
cord-336510-qzm9wgde	275	25	inhibitor	inhibitor	NN
cord-336510-qzm9wgde	276	1	-κB	-κb	ADD
cord-336510-qzm9wgde	276	2	(	(	-LRB-
cord-336510-qzm9wgde	276	3	IκB	iκb	NN
cord-336510-qzm9wgde	276	4	)	)	-RRB-
cord-336510-qzm9wgde	276	5	after	after	IN
cord-336510-qzm9wgde	276	6	phosphorylation	phosphorylation	NN
cord-336510-qzm9wgde	276	7	by	by	IN
cord-336510-qzm9wgde	276	8	an	an	DT
cord-336510-qzm9wgde	276	9	IκB	iκb	NN
cord-336510-qzm9wgde	276	10	kinase	kinase	NN
cord-336510-qzm9wgde	276	11	(	(	-LRB-
cord-336510-qzm9wgde	276	12	IKK	IKK	NNP
cord-336510-qzm9wgde	276	13	)	)	-RRB-
cord-336510-qzm9wgde	276	14	.	.	.
cord-336510-qzm9wgde	277	1	Besides	besides	IN
cord-336510-qzm9wgde	277	2	inducing	induce	VBG
cord-336510-qzm9wgde	277	3	apoptosis	apoptosis	NN
cord-336510-qzm9wgde	277	4	,	,	,
cord-336510-qzm9wgde	277	5	TNFR1	TNFR1	NNP
cord-336510-qzm9wgde	277	6	also	also	RB
cord-336510-qzm9wgde	277	7	activates	activate	VBZ
cord-336510-qzm9wgde	277	8	NF	NF	NNP
cord-336510-qzm9wgde	277	9	-	-	HYPH
cord-336510-qzm9wgde	277	10	κB	κB	NNP
cord-336510-qzm9wgde	278	1	(	(	-LRB-
cord-336510-qzm9wgde	278	2	p50/	p50/	DT
cord-336510-qzm9wgde	278	3	p65	p65	CD
cord-336510-qzm9wgde	278	4	)	)	-RRB-
cord-336510-qzm9wgde	278	5	[	[	-LRB-
cord-336510-qzm9wgde	278	6	229	229	CD
cord-336510-qzm9wgde	278	7	,	,	,
cord-336510-qzm9wgde	278	8	230	230	CD
cord-336510-qzm9wgde	278	9	]	]	-RRB-
cord-336510-qzm9wgde	278	10	.	.	.
cord-336510-qzm9wgde	279	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	279	2	,	,	,
cord-336510-qzm9wgde	279	3	the	the	DT
cord-336510-qzm9wgde	279	4	activator	activator	NN
cord-336510-qzm9wgde	279	5	protein	protein	NN
cord-336510-qzm9wgde	279	6	1	1	CD
cord-336510-qzm9wgde	279	7	(	(	-LRB-
cord-336510-qzm9wgde	279	8	AP-1	AP-1	NNP
cord-336510-qzm9wgde	279	9	)	)	-RRB-
cord-336510-qzm9wgde	279	10	is	be	VBZ
cord-336510-qzm9wgde	279	11	activated	activate	VBN
cord-336510-qzm9wgde	279	12	by	by	IN
cord-336510-qzm9wgde	279	13	mitogen	mitogen	NN
cord-336510-qzm9wgde	279	14	-	-	HYPH
cord-336510-qzm9wgde	279	15	activated	activate	VBN
cord-336510-qzm9wgde	279	16	protein	protein	NN
cord-336510-qzm9wgde	279	17	kinases	kinase	NNS
cord-336510-qzm9wgde	279	18	(	(	-LRB-
cord-336510-qzm9wgde	279	19	MAPKs	MAPKs	NNP
cord-336510-qzm9wgde	279	20	)	)	-RRB-
cord-336510-qzm9wgde	279	21	and	and	CC
cord-336510-qzm9wgde	279	22	together	together	RB
cord-336510-qzm9wgde	279	23	with	with	IN
cord-336510-qzm9wgde	279	24	NF	nf	NN
cord-336510-qzm9wgde	279	25	-	-	HYPH
cord-336510-qzm9wgde	279	26	κB	κB	NNP
cord-336510-qzm9wgde	279	27	primarily	primarily	RB
cord-336510-qzm9wgde	279	28	acts	act	VBZ
cord-336510-qzm9wgde	279	29	in	in	IN
cord-336510-qzm9wgde	279	30	the	the	DT
cord-336510-qzm9wgde	279	31	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	279	32	pathways	pathway	NNS
cord-336510-qzm9wgde	279	33	.	.	.
cord-336510-qzm9wgde	280	1	Thus	thus	RB
cord-336510-qzm9wgde	280	2	,	,	,
cord-336510-qzm9wgde	280	3	signalling	signal	VBG
cord-336510-qzm9wgde	280	4	from	from	IN
cord-336510-qzm9wgde	280	5	the	the	DT
cord-336510-qzm9wgde	280	6	TNF	TNF	NNP
cord-336510-qzm9wgde	280	7	receptor	receptor	NN
cord-336510-qzm9wgde	280	8	family	family	NN
cord-336510-qzm9wgde	280	9	induces	induce	VBZ
cord-336510-qzm9wgde	280	10	a	a	DT
cord-336510-qzm9wgde	280	11	delicate	delicate	JJ
cord-336510-qzm9wgde	280	12	balance	balance	NN
cord-336510-qzm9wgde	280	13	between	between	IN
cord-336510-qzm9wgde	280	14	life	life	NN
cord-336510-qzm9wgde	280	15	and	and	CC
cord-336510-qzm9wgde	280	16	death	death	NN
cord-336510-qzm9wgde	280	17	(	(	-LRB-
cord-336510-qzm9wgde	280	18	apoptosis	apoptosis	NN
cord-336510-qzm9wgde	280	19	)	)	-RRB-
cord-336510-qzm9wgde	280	20	of	of	IN
cord-336510-qzm9wgde	280	21	the	the	DT
cord-336510-qzm9wgde	280	22	cell	cell	NN
cord-336510-qzm9wgde	280	23	.	.	.
cord-336510-qzm9wgde	281	1	Both	both	DT
cord-336510-qzm9wgde	281	2	of	of	IN
cord-336510-qzm9wgde	281	3	the	the	DT
cord-336510-qzm9wgde	281	4	TNF	TNF	NNP
cord-336510-qzm9wgde	281	5	receptors	receptor	NNS
cord-336510-qzm9wgde	281	6	can	can	MD
cord-336510-qzm9wgde	281	7	by	by	IN
cord-336510-qzm9wgde	281	8	proteolytic	proteolytic	JJ
cord-336510-qzm9wgde	281	9	cleavage	cleavage	NN
cord-336510-qzm9wgde	281	10	be	be	VB
cord-336510-qzm9wgde	281	11	converted	convert	VBN
cord-336510-qzm9wgde	281	12	to	to	IN
cord-336510-qzm9wgde	281	13	soluble	soluble	JJ
cord-336510-qzm9wgde	281	14	receptors	receptor	NNS
cord-336510-qzm9wgde	281	15	with	with	IN
cord-336510-qzm9wgde	281	16	the	the	DT
cord-336510-qzm9wgde	281	17	capacity	capacity	NN
cord-336510-qzm9wgde	281	18	to	to	TO
cord-336510-qzm9wgde	281	19	compete	compete	VB
cord-336510-qzm9wgde	281	20	with	with	IN
cord-336510-qzm9wgde	281	21	their	-PRON-	PRP$
cord-336510-qzm9wgde	281	22	signalling	signal	VBG
cord-336510-qzm9wgde	281	23	ancestors	ancestor	NNS
cord-336510-qzm9wgde	281	24	,	,	,
cord-336510-qzm9wgde	281	25	but	but	CC
cord-336510-qzm9wgde	281	26	also	also	RB
cord-336510-qzm9wgde	281	27	act	act	VB
cord-336510-qzm9wgde	281	28	to	to	TO
cord-336510-qzm9wgde	281	29	stabilize	stabilize	VB
cord-336510-qzm9wgde	281	30	the	the	DT
cord-336510-qzm9wgde	281	31	trimeric	trimeric	NNP
cord-336510-qzm9wgde	281	32	TNF	TNF	NNP
cord-336510-qzm9wgde	281	33	and	and	CC
cord-336510-qzm9wgde	281	34	thus	thus	RB
cord-336510-qzm9wgde	281	35	maintain	maintain	VB
cord-336510-qzm9wgde	281	36	its	-PRON-	PRP$
cord-336510-qzm9wgde	281	37	activity	activity	NN
cord-336510-qzm9wgde	281	38	[	[	-LRB-
cord-336510-qzm9wgde	281	39	227	227	CD
cord-336510-qzm9wgde	281	40	,	,	,
cord-336510-qzm9wgde	281	41	231	231	CD
cord-336510-qzm9wgde	281	42	]	]	-RRB-
cord-336510-qzm9wgde	281	43	.	.	.
cord-336510-qzm9wgde	282	1	The	the	DT
cord-336510-qzm9wgde	282	2	TNF	TNF	NNP
cord-336510-qzm9wgde	282	3	superfamily	superfamily	NN
cord-336510-qzm9wgde	282	4	seems	seem	VBZ
cord-336510-qzm9wgde	282	5	to	to	TO
cord-336510-qzm9wgde	282	6	have	have	VB
cord-336510-qzm9wgde	282	7	evolved	evolve	VBN
cord-336510-qzm9wgde	282	8	with	with	IN
cord-336510-qzm9wgde	282	9	the	the	DT
cord-336510-qzm9wgde	282	10	adaptive	adaptive	JJ
cord-336510-qzm9wgde	282	11	immune	immune	JJ
cord-336510-qzm9wgde	282	12	system	system	NN
cord-336510-qzm9wgde	282	13	in	in	IN
cord-336510-qzm9wgde	282	14	vertebrates	vertebrate	NNS
cord-336510-qzm9wgde	282	15	and	and	CC
cord-336510-qzm9wgde	282	16	is	be	VBZ
cord-336510-qzm9wgde	282	17	crucial	crucial	JJ
cord-336510-qzm9wgde	282	18	for	for	IN
cord-336510-qzm9wgde	282	19	the	the	DT
cord-336510-qzm9wgde	282	20	embryonic	embryonic	JJ
cord-336510-qzm9wgde	282	21	development	development	NN
cord-336510-qzm9wgde	282	22	of	of	IN
cord-336510-qzm9wgde	282	23	lymphoid	lymphoid	JJ
cord-336510-qzm9wgde	282	24	tissue	tissue	NN
cord-336510-qzm9wgde	282	25	[	[	-LRB-
cord-336510-qzm9wgde	282	26	223	223	CD
cord-336510-qzm9wgde	282	27	]	]	-RRB-
cord-336510-qzm9wgde	282	28	.	.	.
cord-336510-qzm9wgde	283	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	283	2	,	,	,
cord-336510-qzm9wgde	283	3	TNF	TNF	NNP
cord-336510-qzm9wgde	283	4	is	be	VBZ
cord-336510-qzm9wgde	283	5	,	,	,
cord-336510-qzm9wgde	283	6	as	as	IN
cord-336510-qzm9wgde	283	7	a	a	DT
cord-336510-qzm9wgde	283	8	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	283	9	cytokine	cytokine	NN
cord-336510-qzm9wgde	283	10	,	,	,
cord-336510-qzm9wgde	283	11	involved	involve	VBN
cord-336510-qzm9wgde	283	12	in	in	IN
cord-336510-qzm9wgde	283	13	activation	activation	NN
cord-336510-qzm9wgde	283	14	of	of	IN
cord-336510-qzm9wgde	283	15	many	many	JJ
cord-336510-qzm9wgde	283	16	immune	immune	JJ
cord-336510-qzm9wgde	283	17	cells	cell	NNS
cord-336510-qzm9wgde	283	18	and	and	CC
cord-336510-qzm9wgde	283	19	is	be	VBZ
cord-336510-qzm9wgde	283	20	thus	thus	RB
cord-336510-qzm9wgde	283	21	an	an	DT
cord-336510-qzm9wgde	283	22	important	important	JJ
cord-336510-qzm9wgde	283	23	factor	factor	NN
cord-336510-qzm9wgde	283	24	of	of	IN
cord-336510-qzm9wgde	283	25	both	both	CC
cord-336510-qzm9wgde	283	26	the	the	DT
cord-336510-qzm9wgde	283	27	early	early	JJ
cord-336510-qzm9wgde	283	28	non	non	JJ
cord-336510-qzm9wgde	283	29	-	-	JJ
cord-336510-qzm9wgde	283	30	specific	specific	JJ
cord-336510-qzm9wgde	283	31	and	and	CC
cord-336510-qzm9wgde	283	32	the	the	DT
cord-336510-qzm9wgde	283	33	specific	specific	JJ
cord-336510-qzm9wgde	283	34	immune	immune	JJ
cord-336510-qzm9wgde	283	35	response	response	NN
cord-336510-qzm9wgde	283	36	[	[	-LRB-
cord-336510-qzm9wgde	283	37	232	232	CD
cord-336510-qzm9wgde	283	38	]	]	-RRB-
cord-336510-qzm9wgde	283	39	.	.	.
cord-336510-qzm9wgde	284	1	The	the	DT
cord-336510-qzm9wgde	284	2	importance	importance	NN
cord-336510-qzm9wgde	284	3	of	of	IN
cord-336510-qzm9wgde	284	4	the	the	DT
cord-336510-qzm9wgde	284	5	TNF	TNF	NNP
cord-336510-qzm9wgde	284	6	superfamily	superfamily	NN
cord-336510-qzm9wgde	284	7	in	in	IN
cord-336510-qzm9wgde	284	8	antiviral	antiviral	JJ
cord-336510-qzm9wgde	284	9	defence	defence	NN
cord-336510-qzm9wgde	284	10	is	be	VBZ
cord-336510-qzm9wgde	284	11	illustrated	illustrate	VBN
cord-336510-qzm9wgde	284	12	by	by	IN
cord-336510-qzm9wgde	284	13	the	the	DT
cord-336510-qzm9wgde	284	14	fact	fact	NN
cord-336510-qzm9wgde	284	15	that	that	IN
cord-336510-qzm9wgde	284	16	different	different	JJ
cord-336510-qzm9wgde	284	17	viruses	virus	NNS
cord-336510-qzm9wgde	284	18	have	have	VBP
cord-336510-qzm9wgde	284	19	developed	develop	VBN
cord-336510-qzm9wgde	284	20	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	284	21	for	for	IN
cord-336510-qzm9wgde	284	22	interference	interference	NN
cord-336510-qzm9wgde	284	23	with	with	IN
cord-336510-qzm9wgde	284	24	nearly	nearly	RB
cord-336510-qzm9wgde	284	25	every	every	DT
cord-336510-qzm9wgde	284	26	step	step	NN
cord-336510-qzm9wgde	284	27	of	of	IN
cord-336510-qzm9wgde	284	28	activity	activity	NN
cord-336510-qzm9wgde	284	29	of	of	IN
cord-336510-qzm9wgde	284	30	this	this	DT
cord-336510-qzm9wgde	284	31	system	system	NN
cord-336510-qzm9wgde	284	32	[	[	-LRB-
cord-336510-qzm9wgde	284	33	227	227	CD
cord-336510-qzm9wgde	284	34	,	,	,
cord-336510-qzm9wgde	284	35	229	229	CD
cord-336510-qzm9wgde	284	36	]	]	-RRB-
cord-336510-qzm9wgde	284	37	.	.	.
cord-336510-qzm9wgde	285	1	IL-12	IL-12	NNP
cord-336510-qzm9wgde	285	2	is	be	VBZ
cord-336510-qzm9wgde	285	3	the	the	DT
cord-336510-qzm9wgde	285	4	prime	prime	JJ
cord-336510-qzm9wgde	285	5	member	member	NN
cord-336510-qzm9wgde	285	6	of	of	IN
cord-336510-qzm9wgde	285	7	a	a	DT
cord-336510-qzm9wgde	285	8	small	small	JJ
cord-336510-qzm9wgde	285	9	group	group	NN
cord-336510-qzm9wgde	285	10	of	of	IN
cord-336510-qzm9wgde	285	11	heterodimeric	heterodimeric	NNP
cord-336510-qzm9wgde	285	12	cytokines	cytokine	NNS
cord-336510-qzm9wgde	285	13	,	,	,
cord-336510-qzm9wgde	285	14	all	all	RB
cord-336510-qzm9wgde	285	15	with	with	IN
cord-336510-qzm9wgde	285	16	the	the	DT
cord-336510-qzm9wgde	285	17	capacity	capacity	NN
cord-336510-qzm9wgde	285	18	to	to	TO
cord-336510-qzm9wgde	285	19	induce	induce	VB
cord-336510-qzm9wgde	285	20	production	production	NN
cord-336510-qzm9wgde	285	21	of	of	IN
cord-336510-qzm9wgde	285	22	IFN	IFN	NNP
cord-336510-qzm9wgde	285	23	-	-	HYPH
cord-336510-qzm9wgde	285	24	γ	γ	NNP
cord-336510-qzm9wgde	285	25	in	in	IN
cord-336510-qzm9wgde	285	26	a	a	DT
cord-336510-qzm9wgde	285	27	variety	variety	NN
cord-336510-qzm9wgde	285	28	of	of	IN
cord-336510-qzm9wgde	285	29	cells	cell	NNS
cord-336510-qzm9wgde	285	30	.	.	.
cord-336510-qzm9wgde	286	1	IL-12	IL-12	NNP
cord-336510-qzm9wgde	286	2	was	be	VBD
cord-336510-qzm9wgde	286	3	first	first	RB
cord-336510-qzm9wgde	286	4	described	describe	VBN
cord-336510-qzm9wgde	286	5	as	as	IN
cord-336510-qzm9wgde	286	6	an	an	DT
cord-336510-qzm9wgde	286	7	NK	NK	NNP
cord-336510-qzm9wgde	286	8	cell	cell	NN
cord-336510-qzm9wgde	286	9	stimulatory	stimulatory	JJ
cord-336510-qzm9wgde	286	10	factor	factor	NN
cord-336510-qzm9wgde	286	11	(	(	-LRB-
cord-336510-qzm9wgde	286	12	NKSF	NKSF	NNP
cord-336510-qzm9wgde	286	13	)	)	-RRB-
cord-336510-qzm9wgde	286	14	and	and	CC
cord-336510-qzm9wgde	286	15	identified	identify	VBD
cord-336510-qzm9wgde	286	16	as	as	IN
cord-336510-qzm9wgde	286	17	a	a	DT
cord-336510-qzm9wgde	286	18	heterodimeric	heterodimeric	JJ
cord-336510-qzm9wgde	286	19	molecule	molecule	NN
cord-336510-qzm9wgde	286	20	composed	compose	VBN
cord-336510-qzm9wgde	286	21	of	of	IN
cord-336510-qzm9wgde	286	22	a	a	DT
cord-336510-qzm9wgde	286	23	p40	p40	NN
cord-336510-qzm9wgde	286	24	and	and	CC
cord-336510-qzm9wgde	286	25	a	a	DT
cord-336510-qzm9wgde	286	26	p35	p35	CD
cord-336510-qzm9wgde	286	27	subunit	subunit	NN
cord-336510-qzm9wgde	286	28	,	,	,
cord-336510-qzm9wgde	286	29	which	which	WDT
cord-336510-qzm9wgde	286	30	are	be	VBP
cord-336510-qzm9wgde	286	31	covalently	covalently	RB
cord-336510-qzm9wgde	286	32	linked	link	VBN
cord-336510-qzm9wgde	286	33	[	[	-LRB-
cord-336510-qzm9wgde	286	34	233	233	CD
cord-336510-qzm9wgde	286	35	]	]	-RRB-
cord-336510-qzm9wgde	286	36	.	.	.
cord-336510-qzm9wgde	287	1	The	the	DT
cord-336510-qzm9wgde	287	2	p35	p35	CD
cord-336510-qzm9wgde	287	3	subunit	subunit	NN
cord-336510-qzm9wgde	287	4	has	have	VBZ
cord-336510-qzm9wgde	287	5	homologies	homology	NNS
cord-336510-qzm9wgde	287	6	to	to	IN
cord-336510-qzm9wgde	287	7	IL-6	IL-6	NNP
cord-336510-qzm9wgde	287	8	,	,	,
cord-336510-qzm9wgde	287	9	and	and	CC
cord-336510-qzm9wgde	287	10	p40	p40	NN
cord-336510-qzm9wgde	287	11	is	be	VBZ
cord-336510-qzm9wgde	287	12	homologous	homologous	JJ
cord-336510-qzm9wgde	287	13	to	to	IN
cord-336510-qzm9wgde	287	14	the	the	DT
cord-336510-qzm9wgde	287	15	extracellular	extracellular	JJ
cord-336510-qzm9wgde	287	16	domain	domain	NN
cord-336510-qzm9wgde	287	17	of	of	IN
cord-336510-qzm9wgde	287	18	the	the	DT
cord-336510-qzm9wgde	287	19	haematopoietin	haematopoietin	NNP
cord-336510-qzm9wgde	287	20	receptor	receptor	NN
cord-336510-qzm9wgde	287	21	family	family	NN
cord-336510-qzm9wgde	287	22	,	,	,
cord-336510-qzm9wgde	287	23	particularly	particularly	RB
cord-336510-qzm9wgde	287	24	the	the	DT
cord-336510-qzm9wgde	287	25	IL-6Rα	il-6rα	CD
cord-336510-qzm9wgde	287	26	chain	chain	NN
cord-336510-qzm9wgde	287	27	[	[	-LRB-
cord-336510-qzm9wgde	287	28	234	234	CD
cord-336510-qzm9wgde	287	29	]	]	-RRB-
cord-336510-qzm9wgde	287	30	.	.	.
cord-336510-qzm9wgde	288	1	The	the	DT
cord-336510-qzm9wgde	288	2	two	two	CD
cord-336510-qzm9wgde	288	3	IL-12	IL-12	NNP
cord-336510-qzm9wgde	288	4	subunits	subunit	NNS
cord-336510-qzm9wgde	288	5	are	be	VBP
cord-336510-qzm9wgde	288	6	coded	code	VBN
cord-336510-qzm9wgde	288	7	from	from	IN
cord-336510-qzm9wgde	288	8	different	different	JJ
cord-336510-qzm9wgde	288	9	chromosomes	chromosome	NNS
cord-336510-qzm9wgde	288	10	,	,	,
cord-336510-qzm9wgde	288	11	i.e.	i.e.	FW
cord-336510-qzm9wgde	288	12	the	the	DT
cord-336510-qzm9wgde	288	13	human	human	NN
cord-336510-qzm9wgde	288	14	chromosomes	chromosome	NNS
cord-336510-qzm9wgde	288	15	3	3	CD
cord-336510-qzm9wgde	288	16	and	and	CC
cord-336510-qzm9wgde	288	17	5	5	CD
cord-336510-qzm9wgde	288	18	and	and	CC
cord-336510-qzm9wgde	288	19	the	the	DT
cord-336510-qzm9wgde	288	20	mouse	mouse	NN
cord-336510-qzm9wgde	288	21	chromosomes	chromosome	NNS
cord-336510-qzm9wgde	288	22	6	6	CD
cord-336510-qzm9wgde	288	23	and	and	CC
cord-336510-qzm9wgde	288	24	11	11	CD
cord-336510-qzm9wgde	288	25	,	,	,
cord-336510-qzm9wgde	288	26	respectively	respectively	RB
cord-336510-qzm9wgde	288	27	[	[	-LRB-
cord-336510-qzm9wgde	288	28	235	235	CD
cord-336510-qzm9wgde	288	29	]	]	-RRB-
cord-336510-qzm9wgde	288	30	.	.	.
cord-336510-qzm9wgde	289	1	These	these	DT
cord-336510-qzm9wgde	289	2	genes	gene	NNS
cord-336510-qzm9wgde	289	3	are	be	VBP
cord-336510-qzm9wgde	289	4	regulated	regulate	VBN
cord-336510-qzm9wgde	289	5	separately	separately	RB
cord-336510-qzm9wgde	289	6	,	,	,
cord-336510-qzm9wgde	289	7	and	and	CC
cord-336510-qzm9wgde	289	8	coordinated	coordinated	JJ
cord-336510-qzm9wgde	289	9	induction	induction	NN
cord-336510-qzm9wgde	289	10	in	in	IN
cord-336510-qzm9wgde	289	11	the	the	DT
cord-336510-qzm9wgde	289	12	same	same	JJ
cord-336510-qzm9wgde	289	13	cell	cell	NN
cord-336510-qzm9wgde	289	14	is	be	VBZ
cord-336510-qzm9wgde	289	15	required	require	VBN
cord-336510-qzm9wgde	289	16	for	for	IN
cord-336510-qzm9wgde	289	17	secretion	secretion	NN
cord-336510-qzm9wgde	289	18	of	of	IN
cord-336510-qzm9wgde	289	19	the	the	DT
cord-336510-qzm9wgde	289	20	biologically	biologically	RB
cord-336510-qzm9wgde	289	21	active	active	JJ
cord-336510-qzm9wgde	289	22	IL-12p70	il-12p70	NN
cord-336510-qzm9wgde	289	23	heterodimer	heterodimer	NN
cord-336510-qzm9wgde	289	24	[	[	-LRB-
cord-336510-qzm9wgde	289	25	236	236	CD
cord-336510-qzm9wgde	289	26	]	]	-RRB-
cord-336510-qzm9wgde	289	27	.	.	.
cord-336510-qzm9wgde	290	1	IL-12	IL-12	NNP
cord-336510-qzm9wgde	290	2	is	be	VBZ
cord-336510-qzm9wgde	290	3	produced	produce	VBN
cord-336510-qzm9wgde	290	4	by	by	IN
cord-336510-qzm9wgde	290	5	monocytes	monocyte	NNS
cord-336510-qzm9wgde	290	6	,	,	,
cord-336510-qzm9wgde	290	7	macrophages	macrophage	NNS
cord-336510-qzm9wgde	290	8	,	,	,
cord-336510-qzm9wgde	290	9	dendritic	dendritic	JJ
cord-336510-qzm9wgde	290	10	cells	cell	NNS
cord-336510-qzm9wgde	290	11	,	,	,
cord-336510-qzm9wgde	290	12	neutrophils	neutrophil	NNS
cord-336510-qzm9wgde	290	13	and	and	CC
cord-336510-qzm9wgde	290	14	B	b	NN
cord-336510-qzm9wgde	290	15	cells	cell	NNS
cord-336510-qzm9wgde	290	16	[	[	-LRB-
cord-336510-qzm9wgde	290	17	235	235	CD
cord-336510-qzm9wgde	290	18	,	,	,
cord-336510-qzm9wgde	290	19	237	237	CD
cord-336510-qzm9wgde	290	20	]	]	-RRB-
cord-336510-qzm9wgde	290	21	.	.	.
cord-336510-qzm9wgde	291	1	In	in	IN
cord-336510-qzm9wgde	291	2	the	the	DT
cord-336510-qzm9wgde	291	3	initial	initial	JJ
cord-336510-qzm9wgde	291	4	response	response	NN
cord-336510-qzm9wgde	291	5	of	of	IN
cord-336510-qzm9wgde	291	6	spleen	spleen	NN
cord-336510-qzm9wgde	291	7	cells	cell	NNS
cord-336510-qzm9wgde	291	8	in	in	IN
cord-336510-qzm9wgde	291	9	mice	mouse	NNS
cord-336510-qzm9wgde	291	10	injected	inject	VBN
cord-336510-qzm9wgde	291	11	in	in	IN
cord-336510-qzm9wgde	291	12	vivo	vivo	NN
cord-336510-qzm9wgde	291	13	with	with	IN
cord-336510-qzm9wgde	291	14	extracts	extract	NNS
cord-336510-qzm9wgde	291	15	of	of	IN
cord-336510-qzm9wgde	291	16	toxoplasma	toxoplasma	NN
cord-336510-qzm9wgde	291	17	gondii	gondii	NNS
cord-336510-qzm9wgde	291	18	or	or	CC
cord-336510-qzm9wgde	291	19	with	with	IN
cord-336510-qzm9wgde	291	20	lipopolysaccharide	lipopolysaccharide	NN
cord-336510-qzm9wgde	291	21	(	(	-LRB-
cord-336510-qzm9wgde	291	22	LPS	LPS	NNP
cord-336510-qzm9wgde	291	23	)	)	-RRB-
cord-336510-qzm9wgde	291	24	,	,	,
cord-336510-qzm9wgde	291	25	the	the	DT
cord-336510-qzm9wgde	291	26	cellular	cellular	JJ
cord-336510-qzm9wgde	291	27	source	source	NN
cord-336510-qzm9wgde	291	28	was	be	VBD
cord-336510-qzm9wgde	291	29	found	find	VBN
cord-336510-qzm9wgde	291	30	to	to	TO
cord-336510-qzm9wgde	291	31	be	be	VB
cord-336510-qzm9wgde	291	32	dendritic	dendritic	JJ
cord-336510-qzm9wgde	291	33	cells	cell	NNS
cord-336510-qzm9wgde	291	34	,	,	,
cord-336510-qzm9wgde	291	35	but	but	CC
cord-336510-qzm9wgde	291	36	cultured	cultured	JJ
cord-336510-qzm9wgde	291	37	macrophages	macrophage	NNS
cord-336510-qzm9wgde	291	38	have	have	VBP
cord-336510-qzm9wgde	291	39	by	by	IN
cord-336510-qzm9wgde	291	40	themselves	-PRON-	PRP
cord-336510-qzm9wgde	291	41	also	also	RB
cord-336510-qzm9wgde	291	42	been	be	VBN
cord-336510-qzm9wgde	291	43	shown	show	VBN
cord-336510-qzm9wgde	291	44	to	to	TO
cord-336510-qzm9wgde	291	45	produce	produce	VB
cord-336510-qzm9wgde	291	46	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	291	47	upon	upon	IN
cord-336510-qzm9wgde	291	48	HSV-2	hsv-2	JJ
cord-336510-qzm9wgde	291	49	infection	infection	NN
cord-336510-qzm9wgde	291	50	[	[	-LRB-
cord-336510-qzm9wgde	291	51	238	238	CD
cord-336510-qzm9wgde	291	52	,	,	,
cord-336510-qzm9wgde	291	53	239	239	CD
cord-336510-qzm9wgde	291	54	]	]	-RRB-
cord-336510-qzm9wgde	291	55	.	.	.
cord-336510-qzm9wgde	292	1	Such	such	JJ
cord-336510-qzm9wgde	292	2	differences	difference	NNS
cord-336510-qzm9wgde	292	3	could	could	MD
cord-336510-qzm9wgde	292	4	depend	depend	VB
cord-336510-qzm9wgde	292	5	on	on	IN
cord-336510-qzm9wgde	292	6	variations	variation	NNS
cord-336510-qzm9wgde	292	7	in	in	IN
cord-336510-qzm9wgde	292	8	the	the	DT
cord-336510-qzm9wgde	292	9	signalling	signalling	NN
cord-336510-qzm9wgde	292	10	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	292	11	involved	involve	VBN
cord-336510-qzm9wgde	292	12	,	,	,
cord-336510-qzm9wgde	292	13	which	which	WDT
cord-336510-qzm9wgde	292	14	is	be	VBZ
cord-336510-qzm9wgde	292	15	also	also	RB
cord-336510-qzm9wgde	292	16	illustrated	illustrate	VBN
cord-336510-qzm9wgde	292	17	by	by	IN
cord-336510-qzm9wgde	292	18	the	the	DT
cord-336510-qzm9wgde	292	19	observation	observation	NN
cord-336510-qzm9wgde	292	20	that	that	IN
cord-336510-qzm9wgde	292	21	the	the	DT
cord-336510-qzm9wgde	292	22	production	production	NN
cord-336510-qzm9wgde	292	23	in	in	IN
cord-336510-qzm9wgde	292	24	dendritic	dendritic	JJ
cord-336510-qzm9wgde	292	25	cells	cell	NNS
cord-336510-qzm9wgde	292	26	and	and	CC
cord-336510-qzm9wgde	292	27	macrophages	macrophage	NNS
cord-336510-qzm9wgde	292	28	has	have	VBZ
cord-336510-qzm9wgde	292	29	dif	dif	JJ
cord-336510-qzm9wgde	292	30	-	-	JJ
cord-336510-qzm9wgde	292	31	ferent	ferent	JJ
cord-336510-qzm9wgde	292	32	kinetics	kinetic	NNS
cord-336510-qzm9wgde	292	33	.	.	.
cord-336510-qzm9wgde	293	1	This	this	DT
cord-336510-qzm9wgde	293	2	difference	difference	NN
cord-336510-qzm9wgde	293	3	could	could	MD
cord-336510-qzm9wgde	293	4	be	be	VB
cord-336510-qzm9wgde	293	5	brought	bring	VBN
cord-336510-qzm9wgde	293	6	about	about	RP
cord-336510-qzm9wgde	293	7	by	by	IN
cord-336510-qzm9wgde	293	8	differences	difference	NNS
cord-336510-qzm9wgde	293	9	in	in	IN
cord-336510-qzm9wgde	293	10	the	the	DT
cord-336510-qzm9wgde	293	11	requirement	requirement	NN
cord-336510-qzm9wgde	293	12	for	for	IN
cord-336510-qzm9wgde	293	13	co	co	NN
cord-336510-qzm9wgde	293	14	-	-	NN
cord-336510-qzm9wgde	293	15	stimulation	stimulation	NN
cord-336510-qzm9wgde	293	16	with	with	IN
cord-336510-qzm9wgde	293	17	IFN	IFN	NNP
cord-336510-qzm9wgde	293	18	-	-	HYPH
cord-336510-qzm9wgde	293	19	γ	γ	NNP
cord-336510-qzm9wgde	293	20	[	[	-LRB-
cord-336510-qzm9wgde	293	21	240	240	CD
cord-336510-qzm9wgde	293	22	]	]	-RRB-
cord-336510-qzm9wgde	293	23	.	.	.
cord-336510-qzm9wgde	294	1	A	a	DT
cord-336510-qzm9wgde	294	2	collaborative	collaborative	JJ
cord-336510-qzm9wgde	294	3	action	action	NN
cord-336510-qzm9wgde	294	4	of	of	IN
cord-336510-qzm9wgde	294	5	dendritic	dendritic	JJ
cord-336510-qzm9wgde	294	6	cells	cell	NNS
cord-336510-qzm9wgde	294	7	and	and	CC
cord-336510-qzm9wgde	294	8	macrophages	macrophage	NNS
cord-336510-qzm9wgde	294	9	could	could	MD
cord-336510-qzm9wgde	294	10	be	be	VB
cord-336510-qzm9wgde	294	11	important	important	JJ
cord-336510-qzm9wgde	294	12	,	,	,
cord-336510-qzm9wgde	294	13	as	as	IN
cord-336510-qzm9wgde	294	14	indicated	indicate	VBN
cord-336510-qzm9wgde	294	15	for	for	IN
cord-336510-qzm9wgde	294	16	IL-12	IL-12	NNP
cord-336510-qzm9wgde	294	17	induction	induction	NN
cord-336510-qzm9wgde	294	18	by	by	IN
cord-336510-qzm9wgde	294	19	influenza	influenza	NN
cord-336510-qzm9wgde	294	20	virus	virus	NN
cord-336510-qzm9wgde	294	21	and	and	CC
cord-336510-qzm9wgde	294	22	other	other	JJ
cord-336510-qzm9wgde	294	23	inducers	inducer	NNS
cord-336510-qzm9wgde	294	24	[	[	-LRB-
cord-336510-qzm9wgde	294	25	241	241	CD
cord-336510-qzm9wgde	294	26	]	]	-RRB-
cord-336510-qzm9wgde	294	27	.	.	.
cord-336510-qzm9wgde	295	1	The	the	DT
cord-336510-qzm9wgde	295	2	receptor	receptor	NN
cord-336510-qzm9wgde	295	3	for	for	IN
cord-336510-qzm9wgde	295	4	IL-12	IL-12	NNP
cord-336510-qzm9wgde	295	5	is	be	VBZ
cord-336510-qzm9wgde	295	6	found	find	VBN
cord-336510-qzm9wgde	295	7	on	on	IN
cord-336510-qzm9wgde	295	8	NK	NK	NNP
cord-336510-qzm9wgde	295	9	cells	cell	NNS
cord-336510-qzm9wgde	295	10	,	,	,
cord-336510-qzm9wgde	295	11	T	t	NN
cord-336510-qzm9wgde	295	12	cells	cell	NNS
cord-336510-qzm9wgde	295	13	and	and	CC
cord-336510-qzm9wgde	295	14	dendritic	dendritic	JJ
cord-336510-qzm9wgde	295	15	cells	cell	NNS
cord-336510-qzm9wgde	295	16	and	and	CC
cord-336510-qzm9wgde	295	17	consists	consist	VBZ
cord-336510-qzm9wgde	295	18	of	of	IN
cord-336510-qzm9wgde	295	19	two	two	CD
cord-336510-qzm9wgde	295	20	subunits	subunit	NNS
cord-336510-qzm9wgde	295	21	(	(	-LRB-
cord-336510-qzm9wgde	295	22	β1	β1	NNP
cord-336510-qzm9wgde	295	23	and	and	CC
cord-336510-qzm9wgde	295	24	β2	β2	NNP
cord-336510-qzm9wgde	295	25	)	)	-RRB-
cord-336510-qzm9wgde	295	26	,	,	,
cord-336510-qzm9wgde	295	27	which	which	WDT
cord-336510-qzm9wgde	295	28	signal	signal	NN
cord-336510-qzm9wgde	295	29	by	by	IN
cord-336510-qzm9wgde	295	30	the	the	DT
cord-336510-qzm9wgde	295	31	β2	β2	NN
cord-336510-qzm9wgde	295	32	subunit	subunit	NN
cord-336510-qzm9wgde	295	33	through	through	IN
cord-336510-qzm9wgde	295	34	the	the	DT
cord-336510-qzm9wgde	295	35	JAK	JAK	NNP
cord-336510-qzm9wgde	295	36	/	/	SYM
cord-336510-qzm9wgde	295	37	STAT	STAT	NNP
cord-336510-qzm9wgde	295	38	pathway	pathway	NN
cord-336510-qzm9wgde	295	39	,	,	,
cord-336510-qzm9wgde	295	40	primarily	primarily	RB
cord-336510-qzm9wgde	295	41	by	by	IN
cord-336510-qzm9wgde	295	42	activated	activate	VBN
cord-336510-qzm9wgde	295	43	STAT4	stat4	NN
cord-336510-qzm9wgde	295	44	[	[	-LRB-
cord-336510-qzm9wgde	295	45	235	235	CD
cord-336510-qzm9wgde	295	46	]	]	-RRB-
cord-336510-qzm9wgde	295	47	.	.	.
cord-336510-qzm9wgde	296	1	The	the	DT
cord-336510-qzm9wgde	296	2	primary	primary	JJ
cord-336510-qzm9wgde	296	3	effect	effect	NN
cord-336510-qzm9wgde	296	4	of	of	IN
cord-336510-qzm9wgde	296	5	IL-12	IL-12	NNP
cord-336510-qzm9wgde	296	6	is	be	VBZ
cord-336510-qzm9wgde	296	7	induction	induction	NN
cord-336510-qzm9wgde	296	8	of	of	IN
cord-336510-qzm9wgde	296	9	IFN	IFN	NNP
cord-336510-qzm9wgde	296	10	-	-	HYPH
cord-336510-qzm9wgde	296	11	γ	γ	NN
cord-336510-qzm9wgde	296	12	production	production	NN
cord-336510-qzm9wgde	296	13	in	in	IN
cord-336510-qzm9wgde	296	14	NK	NK	NNP
cord-336510-qzm9wgde	296	15	cells	cell	NNS
cord-336510-qzm9wgde	296	16	and	and	CC
cord-336510-qzm9wgde	296	17	T	t	NN
cord-336510-qzm9wgde	296	18	cells	cell	NNS
cord-336510-qzm9wgde	296	19	,	,	,
cord-336510-qzm9wgde	296	20	and	and	CC
cord-336510-qzm9wgde	296	21	IL-12	IL-12	NNP
cord-336510-qzm9wgde	296	22	activates	activate	VBZ
cord-336510-qzm9wgde	296	23	the	the	DT
cord-336510-qzm9wgde	296	24	cytotoxic	cytotoxic	JJ
cord-336510-qzm9wgde	296	25	potential	potential	NN
cord-336510-qzm9wgde	296	26	of	of	IN
cord-336510-qzm9wgde	296	27	these	these	DT
cord-336510-qzm9wgde	296	28	cells	cell	NNS
cord-336510-qzm9wgde	296	29	.	.	.
cord-336510-qzm9wgde	297	1	The	the	DT
cord-336510-qzm9wgde	297	2	IFN	IFN	NNP
cord-336510-qzm9wgde	297	3	-	-	HYPH
cord-336510-qzm9wgde	297	4	γ	γ	NN
cord-336510-qzm9wgde	297	5	locus	locus	NN
cord-336510-qzm9wgde	297	6	in	in	IN
cord-336510-qzm9wgde	297	7	NK	NK	NNP
cord-336510-qzm9wgde	297	8	cells	cell	NNS
cord-336510-qzm9wgde	297	9	is	be	VBZ
cord-336510-qzm9wgde	297	10	constitutively	constitutively	RB
cord-336510-qzm9wgde	297	11	demethylated	demethylate	VBN
cord-336510-qzm9wgde	297	12	and	and	CC
cord-336510-qzm9wgde	297	13	is	be	VBZ
cord-336510-qzm9wgde	297	14	thus	thus	RB
cord-336510-qzm9wgde	297	15	ready	ready	JJ
cord-336510-qzm9wgde	297	16	for	for	IN
cord-336510-qzm9wgde	297	17	transcription	transcription	NN
cord-336510-qzm9wgde	297	18	of	of	IN
cord-336510-qzm9wgde	297	19	the	the	DT
cord-336510-qzm9wgde	297	20	gene	gene	NN
cord-336510-qzm9wgde	297	21	,	,	,
cord-336510-qzm9wgde	297	22	which	which	WDT
cord-336510-qzm9wgde	297	23	is	be	VBZ
cord-336510-qzm9wgde	297	24	in	in	IN
cord-336510-qzm9wgde	297	25	contrast	contrast	NN
cord-336510-qzm9wgde	297	26	to	to	IN
cord-336510-qzm9wgde	297	27	that	that	DT
cord-336510-qzm9wgde	297	28	of	of	IN
cord-336510-qzm9wgde	297	29	T	t	NN
cord-336510-qzm9wgde	297	30	cells	cell	NNS
cord-336510-qzm9wgde	297	31	,	,	,
cord-336510-qzm9wgde	297	32	[	[	-LRB-
cord-336510-qzm9wgde	297	33	242	242	CD
cord-336510-qzm9wgde	297	34	]	]	-RRB-
cord-336510-qzm9wgde	297	35	.	.	.
cord-336510-qzm9wgde	298	1	Macrophages	macrophage	NNS
cord-336510-qzm9wgde	298	2	and	and	CC
cord-336510-qzm9wgde	298	3	NK	NK	NNP
cord-336510-qzm9wgde	298	4	cells	cell	NNS
cord-336510-qzm9wgde	298	5	are	be	VBP
cord-336510-qzm9wgde	298	6	then	then	RB
cord-336510-qzm9wgde	298	7	stimulated	stimulate	VBN
cord-336510-qzm9wgde	298	8	by	by	IN
cord-336510-qzm9wgde	298	9	IFN	IFN	NNP
cord-336510-qzm9wgde	298	10	-	-	HYPH
cord-336510-qzm9wgde	298	11	γ	γ	NNP
cord-336510-qzm9wgde	298	12	,	,	,
cord-336510-qzm9wgde	298	13	resulting	result	VBG
cord-336510-qzm9wgde	298	14	in	in	IN
cord-336510-qzm9wgde	298	15	activation	activation	NN
cord-336510-qzm9wgde	298	16	for	for	IN
cord-336510-qzm9wgde	298	17	enhanced	enhanced	JJ
cord-336510-qzm9wgde	298	18	antimicrobial	antimicrobial	JJ
cord-336510-qzm9wgde	298	19	capacity	capacity	NN
cord-336510-qzm9wgde	298	20	[	[	-LRB-
cord-336510-qzm9wgde	298	21	243	243	CD
cord-336510-qzm9wgde	298	22	,	,	,
cord-336510-qzm9wgde	298	23	244	244	CD
cord-336510-qzm9wgde	298	24	]	]	-RRB-
cord-336510-qzm9wgde	298	25	.	.	.
cord-336510-qzm9wgde	299	1	IL-12	IL-12	NNP
cord-336510-qzm9wgde	299	2	and	and	CC
cord-336510-qzm9wgde	299	3	IFN	IFN	NNP
cord-336510-qzm9wgde	299	4	-	-	HYPH
cord-336510-qzm9wgde	299	5	γ	γ	NNP
cord-336510-qzm9wgde	299	6	in	in	IN
cord-336510-qzm9wgde	299	7	conjunction	conjunction	NN
cord-336510-qzm9wgde	299	8	are	be	VBP
cord-336510-qzm9wgde	299	9	the	the	DT
cord-336510-qzm9wgde	299	10	main	main	JJ
cord-336510-qzm9wgde	299	11	responsible	responsible	JJ
cord-336510-qzm9wgde	299	12	factors	factor	NNS
cord-336510-qzm9wgde	299	13	for	for	IN
cord-336510-qzm9wgde	299	14	activation	activation	NN
cord-336510-qzm9wgde	299	15	of	of	IN
cord-336510-qzm9wgde	299	16	a	a	DT
cord-336510-qzm9wgde	299	17	Th1-driven	Th1-driven	NNP
cord-336510-qzm9wgde	299	18	adaptive	adaptive	JJ
cord-336510-qzm9wgde	299	19	cellular	cellular	JJ
cord-336510-qzm9wgde	299	20	immune	immune	JJ
cord-336510-qzm9wgde	299	21	response	response	NN
cord-336510-qzm9wgde	299	22	,	,	,
cord-336510-qzm9wgde	299	23	important	important	JJ
cord-336510-qzm9wgde	299	24	for	for	IN
cord-336510-qzm9wgde	299	25	the	the	DT
cord-336510-qzm9wgde	299	26	long	long	JJ
cord-336510-qzm9wgde	299	27	-	-	HYPH
cord-336510-qzm9wgde	299	28	term	term	NN
cord-336510-qzm9wgde	299	29	control	control	NN
cord-336510-qzm9wgde	299	30	of	of	IN
cord-336510-qzm9wgde	299	31	intracellular	intracellular	JJ
cord-336510-qzm9wgde	299	32	pathogens	pathogen	NNS
cord-336510-qzm9wgde	299	33	[	[	-LRB-
cord-336510-qzm9wgde	299	34	235	235	CD
cord-336510-qzm9wgde	299	35	]	]	-RRB-
cord-336510-qzm9wgde	299	36	.	.	.
cord-336510-qzm9wgde	300	1	IL-12	IL-12	NNP
cord-336510-qzm9wgde	300	2	stimulates	stimulate	VBZ
cord-336510-qzm9wgde	300	3	proliferation	proliferation	NN
cord-336510-qzm9wgde	300	4	of	of	IN
cord-336510-qzm9wgde	300	5	naïve	naïve	JJ
cord-336510-qzm9wgde	300	6	T	t	NN
cord-336510-qzm9wgde	300	7	cells	cell	NNS
cord-336510-qzm9wgde	300	8	,	,	,
cord-336510-qzm9wgde	300	9	and	and	CC
cord-336510-qzm9wgde	300	10	in	in	IN
cord-336510-qzm9wgde	300	11	conjunction	conjunction	NN
cord-336510-qzm9wgde	300	12	with	with	IN
cord-336510-qzm9wgde	300	13	IFNγ	IFNγ	NNS
cord-336510-qzm9wgde	300	14	inhibits	inhibit	VBZ
cord-336510-qzm9wgde	300	15	Th2	Th2	NNP
cord-336510-qzm9wgde	300	16	cell	cell	NN
cord-336510-qzm9wgde	300	17	differentiation	differentiation	NN
cord-336510-qzm9wgde	300	18	and	and	CC
cord-336510-qzm9wgde	300	19	the	the	DT
cord-336510-qzm9wgde	300	20	production	production	NN
cord-336510-qzm9wgde	300	21	of	of	IN
cord-336510-qzm9wgde	300	22	Th2	Th2	NNP
cord-336510-qzm9wgde	300	23	cytokines	cytokine	NNS
cord-336510-qzm9wgde	300	24	(	(	-LRB-
cord-336510-qzm9wgde	300	25	e.g.	e.g.	RB
cord-336510-qzm9wgde	300	26	IL-4	IL-4	NNP
cord-336510-qzm9wgde	300	27	,	,	,
cord-336510-qzm9wgde	300	28	IL-5	IL-5	NNP
cord-336510-qzm9wgde	300	29	,	,	,
cord-336510-qzm9wgde	300	30	and	and	CC
cord-336510-qzm9wgde	300	31	IL-13	IL-13	NNP
cord-336510-qzm9wgde	300	32	)	)	-RRB-
cord-336510-qzm9wgde	301	1	[	[	-LRB-
cord-336510-qzm9wgde	301	2	235	235	CD
cord-336510-qzm9wgde	301	3	]	]	-RRB-
cord-336510-qzm9wgde	301	4	.	.	.
cord-336510-qzm9wgde	302	1	Thus	thus	RB
cord-336510-qzm9wgde	302	2	IL-12	IL-12	NNP
cord-336510-qzm9wgde	302	3	holds	hold	VBZ
cord-336510-qzm9wgde	302	4	a	a	DT
cord-336510-qzm9wgde	302	5	key	key	JJ
cord-336510-qzm9wgde	302	6	position	position	NN
cord-336510-qzm9wgde	302	7	in	in	IN
cord-336510-qzm9wgde	302	8	induction	induction	NN
cord-336510-qzm9wgde	302	9	and	and	CC
cord-336510-qzm9wgde	302	10	control	control	NN
cord-336510-qzm9wgde	302	11	of	of	IN
cord-336510-qzm9wgde	302	12	the	the	DT
cord-336510-qzm9wgde	302	13	Th1	th1	CD
cord-336510-qzm9wgde	302	14	response	response	NN
cord-336510-qzm9wgde	302	15	.	.	.
cord-336510-qzm9wgde	303	1	The	the	DT
cord-336510-qzm9wgde	303	2	IL-12-induced	IL-12-induced	NNP
cord-336510-qzm9wgde	303	3	IFN	IFN	NNP
cord-336510-qzm9wgde	303	4	-	-	HYPH
cord-336510-qzm9wgde	303	5	γ	γ	NN
cord-336510-qzm9wgde	303	6	production	production	NN
cord-336510-qzm9wgde	303	7	is	be	VBZ
cord-336510-qzm9wgde	303	8	synergistically	synergistically	RB
cord-336510-qzm9wgde	303	9	enhanced	enhance	VBN
cord-336510-qzm9wgde	303	10	by	by	IN
cord-336510-qzm9wgde	303	11	other	other	JJ
cord-336510-qzm9wgde	303	12	cytokines	cytokine	NNS
cord-336510-qzm9wgde	303	13	such	such	JJ
cord-336510-qzm9wgde	303	14	as	as	IN
cord-336510-qzm9wgde	303	15	TNF	TNF	NNP
cord-336510-qzm9wgde	303	16	and	and	CC
cord-336510-qzm9wgde	303	17	IL-1	IL-1	NNP
cord-336510-qzm9wgde	303	18	[	[	-LRB-
cord-336510-qzm9wgde	303	19	240	240	CD
cord-336510-qzm9wgde	303	20	]	]	-RRB-
cord-336510-qzm9wgde	303	21	,	,	,
cord-336510-qzm9wgde	303	22	and	and	CC
cord-336510-qzm9wgde	303	23	IFN	IFN	NNP
cord-336510-qzm9wgde	303	24	-	-	HYPH
cord-336510-qzm9wgde	303	25	γ	γ	NN
cord-336510-qzm9wgde	303	26	production	production	NN
cord-336510-qzm9wgde	303	27	can	can	MD
cord-336510-qzm9wgde	303	28	even	even	RB
cord-336510-qzm9wgde	303	29	be	be	VB
cord-336510-qzm9wgde	303	30	induced	induce	VBN
cord-336510-qzm9wgde	303	31	in	in	IN
cord-336510-qzm9wgde	303	32	macrophages	macrophage	NNS
cord-336510-qzm9wgde	303	33	by	by	IN
cord-336510-qzm9wgde	303	34	co	co	NN
cord-336510-qzm9wgde	303	35	-	-	NN
cord-336510-qzm9wgde	303	36	stimulation	stimulation	NN
cord-336510-qzm9wgde	303	37	with	with	IN
cord-336510-qzm9wgde	303	38	IL-18	IL-18	NNP
cord-336510-qzm9wgde	303	39	[	[	-LRB-
cord-336510-qzm9wgde	303	40	197	197	CD
cord-336510-qzm9wgde	303	41	,	,	,
cord-336510-qzm9wgde	303	42	245	245	CD
cord-336510-qzm9wgde	303	43	,	,	,
cord-336510-qzm9wgde	303	44	246	246	CD
cord-336510-qzm9wgde	303	45	]	]	-RRB-
cord-336510-qzm9wgde	303	46	,	,	,
cord-336510-qzm9wgde	303	47	a	a	DT
cord-336510-qzm9wgde	303	48	cytokine	cytokine	NN
cord-336510-qzm9wgde	303	49	which	which	WDT
cord-336510-qzm9wgde	303	50	by	by	IN
cord-336510-qzm9wgde	303	51	itself	-PRON-	PRP
cord-336510-qzm9wgde	303	52	does	do	VBZ
cord-336510-qzm9wgde	303	53	not	not	RB
cord-336510-qzm9wgde	303	54	possess	possess	VB
cord-336510-qzm9wgde	303	55	major	major	JJ
cord-336510-qzm9wgde	303	56	IFN	IFN	NNP
cord-336510-qzm9wgde	303	57	-	-	HYPH
cord-336510-qzm9wgde	303	58	γinducing	γinduce	VBG
cord-336510-qzm9wgde	303	59	capacity	capacity	NN
cord-336510-qzm9wgde	303	60	[	[	-LRB-
cord-336510-qzm9wgde	303	61	240	240	CD
cord-336510-qzm9wgde	303	62	]	]	-RRB-
cord-336510-qzm9wgde	303	63	.	.	.
cord-336510-qzm9wgde	304	1	A	a	DT
cord-336510-qzm9wgde	304	2	positive	positive	JJ
cord-336510-qzm9wgde	304	3	feed	feed	NN
cord-336510-qzm9wgde	304	4	-	-	HYPH
cord-336510-qzm9wgde	304	5	back	back	NN
cord-336510-qzm9wgde	304	6	loop	loop	NN
cord-336510-qzm9wgde	304	7	is	be	VBZ
cord-336510-qzm9wgde	304	8	initiated	initiate	VBN
cord-336510-qzm9wgde	304	9	by	by	IN
cord-336510-qzm9wgde	304	10	the	the	DT
cord-336510-qzm9wgde	304	11	IL-12-induced	IL-12-induced	NNP
cord-336510-qzm9wgde	304	12	production	production	NN
cord-336510-qzm9wgde	304	13	of	of	IN
cord-336510-qzm9wgde	304	14	IFN	IFN	NNP
cord-336510-qzm9wgde	304	15	-	-	HYPH
cord-336510-qzm9wgde	304	16	γ	γ	NNP
cord-336510-qzm9wgde	304	17	,	,	,
cord-336510-qzm9wgde	304	18	in	in	IN
cord-336510-qzm9wgde	304	19	that	that	IN
cord-336510-qzm9wgde	304	20	IFN	IFN	NNP
cord-336510-qzm9wgde	304	21	-	-	HYPH
cord-336510-qzm9wgde	304	22	γ	γ	NNP
cord-336510-qzm9wgde	304	23	is	be	VBZ
cord-336510-qzm9wgde	304	24	an	an	DT
cord-336510-qzm9wgde	304	25	important	important	JJ
cord-336510-qzm9wgde	304	26	primer	primer	NN
cord-336510-qzm9wgde	304	27	of	of	IN
cord-336510-qzm9wgde	304	28	IL-12	IL-12	NNP
cord-336510-qzm9wgde	304	29	production	production	NN
cord-336510-qzm9wgde	304	30	,	,	,
cord-336510-qzm9wgde	304	31	thus	thus	RB
cord-336510-qzm9wgde	304	32	accelerating	accelerate	VBG
cord-336510-qzm9wgde	304	33	the	the	DT
cord-336510-qzm9wgde	304	34	system	system	NN
cord-336510-qzm9wgde	304	35	[	[	-LRB-
cord-336510-qzm9wgde	304	36	247	247	CD
cord-336510-qzm9wgde	304	37	]	]	-RRB-
cord-336510-qzm9wgde	304	38	.	.	.
cord-336510-qzm9wgde	305	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	305	2	,	,	,
cord-336510-qzm9wgde	305	3	T	t	NN
cord-336510-qzm9wgde	305	4	cells	cell	NNS
cord-336510-qzm9wgde	305	5	enhance	enhance	VBP
cord-336510-qzm9wgde	305	6	IL-12	IL-12	NNP
cord-336510-qzm9wgde	305	7	production	production	NN
cord-336510-qzm9wgde	305	8	through	through	IN
cord-336510-qzm9wgde	305	9	signals	signal	NNS
cord-336510-qzm9wgde	305	10	of	of	IN
cord-336510-qzm9wgde	305	11	the	the	DT
cord-336510-qzm9wgde	305	12	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	305	13	TNF	TNF	NNP
cord-336510-qzm9wgde	305	14	family	family	NN
cord-336510-qzm9wgde	305	15	[	[	-LRB-
cord-336510-qzm9wgde	305	16	240	240	CD
cord-336510-qzm9wgde	305	17	]	]	-RRB-
cord-336510-qzm9wgde	305	18	.	.	.
cord-336510-qzm9wgde	306	1	In	in	IN
cord-336510-qzm9wgde	306	2	virus	virus	NN
cord-336510-qzm9wgde	306	3	-	-	HYPH
cord-336510-qzm9wgde	306	4	infected	infect	VBN
cord-336510-qzm9wgde	306	5	macrophages	macrophage	NNS
cord-336510-qzm9wgde	306	6	a	a	DT
cord-336510-qzm9wgde	306	7	similar	similar	JJ
cord-336510-qzm9wgde	306	8	autocrine	autocrine	NN
cord-336510-qzm9wgde	306	9	feed	feed	NN
cord-336510-qzm9wgde	306	10	-	-	HYPH
cord-336510-qzm9wgde	306	11	back	back	NN
cord-336510-qzm9wgde	306	12	loop	loop	NN
cord-336510-qzm9wgde	306	13	involving	involve	VBG
cord-336510-qzm9wgde	306	14	IL-12	IL-12	NNP
cord-336510-qzm9wgde	306	15	,	,	,
cord-336510-qzm9wgde	306	16	IL-18	IL-18	NNP
cord-336510-qzm9wgde	306	17	,	,	,
cord-336510-qzm9wgde	306	18	IFN	IFN	NNP
cord-336510-qzm9wgde	306	19	-	-	HYPH
cord-336510-qzm9wgde	306	20	α	α	NNP
cord-336510-qzm9wgde	306	21	/	/	SYM
cord-336510-qzm9wgde	306	22	β	β	NN
cord-336510-qzm9wgde	306	23	,	,	,
cord-336510-qzm9wgde	306	24	and	and	CC
cord-336510-qzm9wgde	306	25	IFN	IFN	NNP
cord-336510-qzm9wgde	306	26	-	-	HYPH
cord-336510-qzm9wgde	306	27	γ	γ	NNP
cord-336510-qzm9wgde	306	28	could	could	MD
cord-336510-qzm9wgde	306	29	be	be	VB
cord-336510-qzm9wgde	306	30	speculated	speculate	VBN
cord-336510-qzm9wgde	306	31	[	[	-LRB-
cord-336510-qzm9wgde	306	32	248	248	CD
cord-336510-qzm9wgde	306	33	]	]	-RRB-
cord-336510-qzm9wgde	306	34	.	.	.
cord-336510-qzm9wgde	307	1	This	this	DT
cord-336510-qzm9wgde	307	2	potentially	potentially	RB
cord-336510-qzm9wgde	307	3	harmful	harmful	JJ
cord-336510-qzm9wgde	307	4	situation	situation	NN
cord-336510-qzm9wgde	307	5	,	,	,
cord-336510-qzm9wgde	307	6	with	with	IN
cord-336510-qzm9wgde	307	7	accelerating	accelerate	VBG
cord-336510-qzm9wgde	307	8	IFNγ	IFNγ	NNS
cord-336510-qzm9wgde	307	9	production	production	NN
cord-336510-qzm9wgde	307	10	,	,	,
cord-336510-qzm9wgde	307	11	regulated	regulate	VBN
cord-336510-qzm9wgde	307	12	in	in	IN
cord-336510-qzm9wgde	307	13	a	a	DT
cord-336510-qzm9wgde	307	14	positive	positive	JJ
cord-336510-qzm9wgde	307	15	feed	feed	NN
cord-336510-qzm9wgde	307	16	-	-	HYPH
cord-336510-qzm9wgde	307	17	back	back	NN
cord-336510-qzm9wgde	307	18	loop	loop	NN
cord-336510-qzm9wgde	307	19	by	by	IN
cord-336510-qzm9wgde	307	20	IL-12	IL-12	NNP
cord-336510-qzm9wgde	307	21	,	,	,
cord-336510-qzm9wgde	307	22	is	be	VBZ
cord-336510-qzm9wgde	307	23	inhibited	inhibit	VBN
cord-336510-qzm9wgde	307	24	by	by	IN
cord-336510-qzm9wgde	307	25	cytokines	cytokine	NNS
cord-336510-qzm9wgde	307	26	possessing	possess	VBG
cord-336510-qzm9wgde	307	27	anti	anti	JJ
cord-336510-qzm9wgde	307	28	-	-	JJ
cord-336510-qzm9wgde	307	29	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	307	30	properties	property	NNS
cord-336510-qzm9wgde	307	31	.	.	.
cord-336510-qzm9wgde	308	1	Among	among	IN
cord-336510-qzm9wgde	308	2	these	these	DT
cord-336510-qzm9wgde	308	3	IL-10	IL-10	NNP
cord-336510-qzm9wgde	308	4	holds	hold	VBZ
cord-336510-qzm9wgde	308	5	a	a	DT
cord-336510-qzm9wgde	308	6	crucial	crucial	JJ
cord-336510-qzm9wgde	308	7	position	position	NN
cord-336510-qzm9wgde	308	8	as	as	IN
cord-336510-qzm9wgde	308	9	an	an	DT
cord-336510-qzm9wgde	308	10	inhibitor	inhibitor	NN
cord-336510-qzm9wgde	308	11	of	of	IN
cord-336510-qzm9wgde	308	12	IL-12	IL-12	NNP
cord-336510-qzm9wgde	308	13	production	production	NN
cord-336510-qzm9wgde	308	14	,	,	,
cord-336510-qzm9wgde	308	15	an	an	DT
cord-336510-qzm9wgde	308	16	effect	effect	NN
cord-336510-qzm9wgde	308	17	which	which	WDT
cord-336510-qzm9wgde	308	18	is	be	VBZ
cord-336510-qzm9wgde	308	19	also	also	RB
cord-336510-qzm9wgde	308	20	conducted	conduct	VBN
cord-336510-qzm9wgde	308	21	by	by	IN
cord-336510-qzm9wgde	308	22	transforming	transform	VBG
cord-336510-qzm9wgde	308	23	growth	growth	NN
cord-336510-qzm9wgde	308	24	factor	factor	NN
cord-336510-qzm9wgde	308	25	-	-	HYPH
cord-336510-qzm9wgde	308	26	β	β	NN
cord-336510-qzm9wgde	308	27	(	(	-LRB-
cord-336510-qzm9wgde	308	28	TGF	TGF	NNP
cord-336510-qzm9wgde	308	29	-	-	HYPH
cord-336510-qzm9wgde	308	30	β	β	NNP
cord-336510-qzm9wgde	308	31	)	)	-RRB-
cord-336510-qzm9wgde	308	32	[	[	-LRB-
cord-336510-qzm9wgde	308	33	249	249	CD
cord-336510-qzm9wgde	308	34	]	]	-RRB-
cord-336510-qzm9wgde	308	35	[	[	-LRB-
cord-336510-qzm9wgde	308	36	250	250	CD
cord-336510-qzm9wgde	308	37	]	]	-RRB-
cord-336510-qzm9wgde	308	38	[	[	-LRB-
cord-336510-qzm9wgde	308	39	251	251	CD
cord-336510-qzm9wgde	308	40	]	]	-RRB-
cord-336510-qzm9wgde	309	1	.The	.The	.
cord-336510-qzm9wgde	310	1	Th2	Th2	NNP
cord-336510-qzm9wgde	310	2	cytokines	cytokine	NNS
cord-336510-qzm9wgde	310	3	of	of	IN
cord-336510-qzm9wgde	310	4	the	the	DT
cord-336510-qzm9wgde	310	5	other	other	JJ
cord-336510-qzm9wgde	310	6	side	side	NN
cord-336510-qzm9wgde	310	7	of	of	IN
cord-336510-qzm9wgde	310	8	the	the	DT
cord-336510-qzm9wgde	310	9	adaptive	adaptive	JJ
cord-336510-qzm9wgde	310	10	response	response	NN
cord-336510-qzm9wgde	310	11	,	,	,
cord-336510-qzm9wgde	310	12	IL-4	IL-4	NNP
cord-336510-qzm9wgde	310	13	and	and	CC
cord-336510-qzm9wgde	310	14	IL-13	IL-13	NNP
cord-336510-qzm9wgde	310	15	,	,	,
cord-336510-qzm9wgde	311	1	inhibit	inhibit	VB
cord-336510-qzm9wgde	311	2	IL-12	IL-12	NNP
cord-336510-qzm9wgde	311	3	induction	induction	NN
cord-336510-qzm9wgde	311	4	in	in	IN
cord-336510-qzm9wgde	311	5	the	the	DT
cord-336510-qzm9wgde	311	6	early	early	JJ
cord-336510-qzm9wgde	311	7	phases	phase	NNS
cord-336510-qzm9wgde	311	8	of	of	IN
cord-336510-qzm9wgde	311	9	stimulation	stimulation	NN
cord-336510-qzm9wgde	311	10	,	,	,
cord-336510-qzm9wgde	311	11	but	but	CC
cord-336510-qzm9wgde	311	12	later	later	RB
cord-336510-qzm9wgde	311	13	they	-PRON-	PRP
cord-336510-qzm9wgde	311	14	can	can	MD
cord-336510-qzm9wgde	311	15	be	be	VB
cord-336510-qzm9wgde	311	16	potent	potent	JJ
cord-336510-qzm9wgde	311	17	inducers	inducer	NNS
cord-336510-qzm9wgde	311	18	of	of	IN
cord-336510-qzm9wgde	311	19	IL-12	IL-12	NNP
cord-336510-qzm9wgde	311	20	production	production	NN
cord-336510-qzm9wgde	311	21	,	,	,
cord-336510-qzm9wgde	311	22	although	although	IN
cord-336510-qzm9wgde	311	23	they	-PRON-	PRP
cord-336510-qzm9wgde	311	24	still	still	RB
cord-336510-qzm9wgde	311	25	inhibit	inhibit	VBP
cord-336510-qzm9wgde	311	26	many	many	JJ
cord-336510-qzm9wgde	311	27	of	of	IN
cord-336510-qzm9wgde	311	28	the	the	DT
cord-336510-qzm9wgde	311	29	IFN	IFN	NNP
cord-336510-qzm9wgde	311	30	-	-	HYPH
cord-336510-qzm9wgde	311	31	γ	γ	NN
cord-336510-qzm9wgde	311	32	-	-	HYPH
cord-336510-qzm9wgde	311	33	induced	induce	VBN
cord-336510-qzm9wgde	311	34	activities	activity	NNS
cord-336510-qzm9wgde	311	35	[	[	-LRB-
cord-336510-qzm9wgde	311	36	212	212	CD
cord-336510-qzm9wgde	311	37	,	,	,
cord-336510-qzm9wgde	311	38	252	252	CD
cord-336510-qzm9wgde	311	39	,	,	,
cord-336510-qzm9wgde	311	40	253	253	CD
cord-336510-qzm9wgde	311	41	]	]	-RRB-
cord-336510-qzm9wgde	311	42	.	.	.
cord-336510-qzm9wgde	312	1	Phagocytosis	Phagocytosis	NNP
cord-336510-qzm9wgde	312	2	of	of	IN
cord-336510-qzm9wgde	312	3	apoptotic	apoptotic	JJ
cord-336510-qzm9wgde	312	4	cells	cell	NNS
cord-336510-qzm9wgde	312	5	by	by	IN
cord-336510-qzm9wgde	312	6	macrophages	macrophage	NNS
cord-336510-qzm9wgde	312	7	inhibits	inhibit	VBZ
cord-336510-qzm9wgde	312	8	production	production	NN
cord-336510-qzm9wgde	312	9	of	of	IN
cord-336510-qzm9wgde	312	10	IL-12	IL-12	NNP
cord-336510-qzm9wgde	312	11	,	,	,
cord-336510-qzm9wgde	312	12	a	a	DT
cord-336510-qzm9wgde	312	13	regulatory	regulatory	JJ
cord-336510-qzm9wgde	312	14	mechanism	mechanism	NN
cord-336510-qzm9wgde	312	15	which	which	WDT
cord-336510-qzm9wgde	312	16	seems	seem	VBZ
cord-336510-qzm9wgde	312	17	to	to	TO
cord-336510-qzm9wgde	312	18	be	be	VB
cord-336510-qzm9wgde	312	19	important	important	JJ
cord-336510-qzm9wgde	312	20	in	in	IN
cord-336510-qzm9wgde	312	21	restriction	restriction	NN
cord-336510-qzm9wgde	312	22	of	of	IN
cord-336510-qzm9wgde	312	23	the	the	DT
cord-336510-qzm9wgde	312	24	damages	damage	NNS
cord-336510-qzm9wgde	312	25	induced	induce	VBN
cord-336510-qzm9wgde	312	26	by	by	IN
cord-336510-qzm9wgde	312	27	uncontrolled	uncontrolled	JJ
cord-336510-qzm9wgde	312	28	defence	defence	NN
cord-336510-qzm9wgde	312	29	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	312	30	[	[	-LRB-
cord-336510-qzm9wgde	312	31	254	254	CD
cord-336510-qzm9wgde	312	32	]	]	-RRB-
cord-336510-qzm9wgde	312	33	.	.	.
cord-336510-qzm9wgde	313	1	Injection	injection	NN
cord-336510-qzm9wgde	313	2	of	of	IN
cord-336510-qzm9wgde	313	3	high	high	JJ
cord-336510-qzm9wgde	313	4	doses	dose	NNS
cord-336510-qzm9wgde	313	5	of	of	IN
cord-336510-qzm9wgde	313	6	IL-12	IL-12	NNP
cord-336510-qzm9wgde	313	7	to	to	IN
cord-336510-qzm9wgde	313	8	virus	virus	NN
cord-336510-qzm9wgde	313	9	-	-	HYPH
cord-336510-qzm9wgde	313	10	infected	infect	VBN
cord-336510-qzm9wgde	313	11	mice	mouse	NNS
cord-336510-qzm9wgde	313	12	is	be	VBZ
cord-336510-qzm9wgde	313	13	toxic	toxic	JJ
cord-336510-qzm9wgde	313	14	,	,	,
cord-336510-qzm9wgde	313	15	and	and	CC
cord-336510-qzm9wgde	313	16	leads	lead	VBZ
cord-336510-qzm9wgde	313	17	to	to	IN
cord-336510-qzm9wgde	313	18	death	death	NN
cord-336510-qzm9wgde	313	19	with	with	IN
cord-336510-qzm9wgde	313	20	the	the	DT
cord-336510-qzm9wgde	313	21	pathology	pathology	NN
cord-336510-qzm9wgde	313	22	of	of	IN
cord-336510-qzm9wgde	313	23	TNF	TNF	NNP
cord-336510-qzm9wgde	313	24	-	-	HYPH
cord-336510-qzm9wgde	313	25	related	relate	VBN
cord-336510-qzm9wgde	313	26	toxic	toxic	JJ
cord-336510-qzm9wgde	313	27	shock	shock	NN
cord-336510-qzm9wgde	313	28	,	,	,
cord-336510-qzm9wgde	313	29	an	an	DT
cord-336510-qzm9wgde	313	30	effect	effect	NN
cord-336510-qzm9wgde	313	31	which	which	WDT
cord-336510-qzm9wgde	313	32	was	be	VBD
cord-336510-qzm9wgde	313	33	explained	explain	VBN
cord-336510-qzm9wgde	313	34	by	by	IN
cord-336510-qzm9wgde	313	35	increased	increase	VBN
cord-336510-qzm9wgde	313	36	sensitivity	sensitivity	NN
cord-336510-qzm9wgde	313	37	to	to	IN
cord-336510-qzm9wgde	313	38	the	the	DT
cord-336510-qzm9wgde	313	39	toxic	toxic	JJ
cord-336510-qzm9wgde	313	40	effects	effect	NNS
cord-336510-qzm9wgde	313	41	of	of	IN
cord-336510-qzm9wgde	313	42	TNF	TNF	NNP
cord-336510-qzm9wgde	313	43	,	,	,
cord-336510-qzm9wgde	313	44	and	and	CC
cord-336510-qzm9wgde	313	45	found	find	VBD
cord-336510-qzm9wgde	313	46	to	to	TO
cord-336510-qzm9wgde	313	47	be	be	VB
cord-336510-qzm9wgde	313	48	dependent	dependent	JJ
cord-336510-qzm9wgde	313	49	on	on	IN
cord-336510-qzm9wgde	313	50	the	the	DT
cord-336510-qzm9wgde	313	51	genetic	genetic	JJ
cord-336510-qzm9wgde	313	52	constitution	constitution	NN
cord-336510-qzm9wgde	313	53	of	of	IN
cord-336510-qzm9wgde	313	54	the	the	DT
cord-336510-qzm9wgde	313	55	host	host	NN
cord-336510-qzm9wgde	313	56	[	[	-LRB-
cord-336510-qzm9wgde	313	57	255	255	CD
cord-336510-qzm9wgde	313	58	,	,	,
cord-336510-qzm9wgde	313	59	256	256	CD
cord-336510-qzm9wgde	313	60	]	]	-RRB-
cord-336510-qzm9wgde	313	61	.	.	.
cord-336510-qzm9wgde	314	1	The	the	DT
cord-336510-qzm9wgde	314	2	small	small	JJ
cord-336510-qzm9wgde	314	3	IL-12	IL-12	NNP
cord-336510-qzm9wgde	314	4	cytokine	cytokine	NN
cord-336510-qzm9wgde	314	5	family	family	NN
cord-336510-qzm9wgde	314	6	also	also	RB
cord-336510-qzm9wgde	314	7	includes	include	VBZ
cord-336510-qzm9wgde	314	8	two	two	CD
cord-336510-qzm9wgde	314	9	other	other	JJ
cord-336510-qzm9wgde	314	10	heterodimeric	heterodimeric	JJ
cord-336510-qzm9wgde	314	11	cytokines	cytokine	NNS
cord-336510-qzm9wgde	314	12	,	,	,
cord-336510-qzm9wgde	314	13	IL-23	IL-23	NNP
cord-336510-qzm9wgde	314	14	and	and	CC
cord-336510-qzm9wgde	314	15	IL-27	IL-27	NNP
cord-336510-qzm9wgde	314	16	,	,	,
cord-336510-qzm9wgde	314	17	and	and	CC
cord-336510-qzm9wgde	314	18	a	a	DT
cord-336510-qzm9wgde	314	19	homodimer	homodimer	NN
cord-336510-qzm9wgde	314	20	of	of	IN
cord-336510-qzm9wgde	314	21	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	314	22	.	.	.
cord-336510-qzm9wgde	315	1	The	the	DT
cord-336510-qzm9wgde	315	2	latter	latter	NN
cord-336510-qzm9wgde	315	3	is	be	VBZ
cord-336510-qzm9wgde	315	4	found	find	VBN
cord-336510-qzm9wgde	315	5	in	in	IN
cord-336510-qzm9wgde	315	6	vivo	vivo	NN
cord-336510-qzm9wgde	315	7	in	in	IN
cord-336510-qzm9wgde	315	8	mice	mouse	NNS
cord-336510-qzm9wgde	315	9	and	and	CC
cord-336510-qzm9wgde	315	10	functions	function	NNS
cord-336510-qzm9wgde	315	11	as	as	IN
cord-336510-qzm9wgde	315	12	an	an	DT
cord-336510-qzm9wgde	315	13	antagonist	antagonist	NN
cord-336510-qzm9wgde	315	14	of	of	IN
cord-336510-qzm9wgde	315	15	IL-12	IL-12	NNP
cord-336510-qzm9wgde	315	16	,	,	,
cord-336510-qzm9wgde	315	17	but	but	CC
cord-336510-qzm9wgde	315	18	it	-PRON-	PRP
cord-336510-qzm9wgde	315	19	is	be	VBZ
cord-336510-qzm9wgde	315	20	debated	debate	VBN
cord-336510-qzm9wgde	315	21	whether	whether	IN
cord-336510-qzm9wgde	315	22	it	-PRON-	PRP
cord-336510-qzm9wgde	315	23	exists	exist	VBZ
cord-336510-qzm9wgde	315	24	in	in	IN
cord-336510-qzm9wgde	315	25	humans	human	NNS
cord-336510-qzm9wgde	315	26	[	[	-LRB-
cord-336510-qzm9wgde	315	27	257	257	CD
cord-336510-qzm9wgde	315	28	,	,	,
cord-336510-qzm9wgde	315	29	258	258	CD
cord-336510-qzm9wgde	315	30	]	]	-RRB-
cord-336510-qzm9wgde	315	31	.	.	.
cord-336510-qzm9wgde	316	1	IL-23	IL-23	NNP
cord-336510-qzm9wgde	316	2	is	be	VBZ
cord-336510-qzm9wgde	316	3	composed	compose	VBN
cord-336510-qzm9wgde	316	4	of	of	IN
cord-336510-qzm9wgde	316	5	the	the	DT
cord-336510-qzm9wgde	316	6	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	316	7	and	and	CC
cord-336510-qzm9wgde	316	8	a	a	DT
cord-336510-qzm9wgde	316	9	p19	p19	NN
cord-336510-qzm9wgde	316	10	subunit	subunit	NN
cord-336510-qzm9wgde	316	11	and	and	CC
cord-336510-qzm9wgde	316	12	likewise	likewise	RB
cord-336510-qzm9wgde	316	13	binds	bind	VBZ
cord-336510-qzm9wgde	316	14	to	to	IN
cord-336510-qzm9wgde	316	15	a	a	DT
cord-336510-qzm9wgde	316	16	receptor	receptor	NN
cord-336510-qzm9wgde	316	17	with	with	IN
cord-336510-qzm9wgde	316	18	one	one	CD
cord-336510-qzm9wgde	316	19	of	of	IN
cord-336510-qzm9wgde	316	20	the	the	DT
cord-336510-qzm9wgde	316	21	IL-12	IL-12	NNP
cord-336510-qzm9wgde	316	22	receptor	receptor	NN
cord-336510-qzm9wgde	316	23	subunits	subunit	NNS
cord-336510-qzm9wgde	316	24	(	(	-LRB-
cord-336510-qzm9wgde	316	25	IL-12Rβ1	il-12rβ1	NN
cord-336510-qzm9wgde	316	26	)	)	-RRB-
cord-336510-qzm9wgde	316	27	and	and	CC
cord-336510-qzm9wgde	316	28	a	a	DT
cord-336510-qzm9wgde	316	29	distinct	distinct	JJ
cord-336510-qzm9wgde	316	30	IL-23R	IL-23R	NNP
cord-336510-qzm9wgde	316	31	subunit	subunit	NN
cord-336510-qzm9wgde	316	32	[	[	-LRB-
cord-336510-qzm9wgde	316	33	240	240	CD
cord-336510-qzm9wgde	316	34	,	,	,
cord-336510-qzm9wgde	316	35	259	259	CD
cord-336510-qzm9wgde	316	36	]	]	-RRB-
cord-336510-qzm9wgde	316	37	.	.	.
cord-336510-qzm9wgde	317	1	The	the	DT
cord-336510-qzm9wgde	317	2	production	production	NN
cord-336510-qzm9wgde	317	3	and	and	CC
cord-336510-qzm9wgde	317	4	function	function	NN
cord-336510-qzm9wgde	317	5	of	of	IN
cord-336510-qzm9wgde	317	6	IL-23	IL-23	NNP
cord-336510-qzm9wgde	317	7	is	be	VBZ
cord-336510-qzm9wgde	317	8	quite	quite	RB
cord-336510-qzm9wgde	317	9	similar	similar	JJ
cord-336510-qzm9wgde	317	10	to	to	IN
cord-336510-qzm9wgde	317	11	that	that	DT
cord-336510-qzm9wgde	317	12	of	of	IN
cord-336510-qzm9wgde	317	13	IL-12	IL-12	NNP
cord-336510-qzm9wgde	317	14	,	,	,
cord-336510-qzm9wgde	317	15	but	but	CC
cord-336510-qzm9wgde	317	16	IL-23	IL-23	NNP
cord-336510-qzm9wgde	317	17	has	have	VBZ
cord-336510-qzm9wgde	317	18	a	a	DT
cord-336510-qzm9wgde	317	19	unique	unique	JJ
cord-336510-qzm9wgde	317	20	capacity	capacity	NN
cord-336510-qzm9wgde	317	21	to	to	TO
cord-336510-qzm9wgde	317	22	induce	induce	VB
cord-336510-qzm9wgde	317	23	proliferation	proliferation	NN
cord-336510-qzm9wgde	317	24	of	of	IN
cord-336510-qzm9wgde	317	25	memory	memory	NN
cord-336510-qzm9wgde	317	26	T	t	NN
cord-336510-qzm9wgde	317	27	cells	cell	NNS
cord-336510-qzm9wgde	317	28	[	[	-LRB-
cord-336510-qzm9wgde	317	29	235	235	CD
cord-336510-qzm9wgde	317	30	]	]	-RRB-
cord-336510-qzm9wgde	317	31	,	,	,
cord-336510-qzm9wgde	317	32	and	and	CC
cord-336510-qzm9wgde	317	33	it	-PRON-	PRP
cord-336510-qzm9wgde	317	34	has	have	VBZ
cord-336510-qzm9wgde	317	35	been	be	VBN
cord-336510-qzm9wgde	317	36	found	find	VBN
cord-336510-qzm9wgde	317	37	in	in	IN
cord-336510-qzm9wgde	317	38	nervous	nervous	JJ
cord-336510-qzm9wgde	317	39	ganglia	ganglion	NNS
cord-336510-qzm9wgde	317	40	of	of	IN
cord-336510-qzm9wgde	317	41	HSV	HSV	NNP
cord-336510-qzm9wgde	317	42	-	-	HYPH
cord-336510-qzm9wgde	317	43	infected	infect	VBN
cord-336510-qzm9wgde	317	44	mice	mouse	NNS
cord-336510-qzm9wgde	317	45	on	on	IN
cord-336510-qzm9wgde	317	46	day	day	NN
cord-336510-qzm9wgde	317	47	3	3	CD
cord-336510-qzm9wgde	317	48	of	of	IN
cord-336510-qzm9wgde	317	49	infection	infection	NN
cord-336510-qzm9wgde	318	1	[	[	-LRB-
cord-336510-qzm9wgde	318	2	260	260	CD
cord-336510-qzm9wgde	318	3	]	]	-RRB-
cord-336510-qzm9wgde	318	4	.	.	.
cord-336510-qzm9wgde	319	1	IL-23	IL-23	NNP
cord-336510-qzm9wgde	319	2	drives	drive	VBZ
cord-336510-qzm9wgde	319	3	IL-17	IL-17	NNP
cord-336510-qzm9wgde	319	4	production	production	NN
cord-336510-qzm9wgde	319	5	of	of	IN
cord-336510-qzm9wgde	319	6	NK	NK	NNP
cord-336510-qzm9wgde	319	7	cells	cell	NNS
cord-336510-qzm9wgde	319	8	,	,	,
cord-336510-qzm9wgde	319	9	which	which	WDT
cord-336510-qzm9wgde	319	10	mobilizes	mobilize	VBZ
cord-336510-qzm9wgde	319	11	neutrophils	neutrophil	NNS
cord-336510-qzm9wgde	319	12	and	and	CC
cord-336510-qzm9wgde	319	13	promotes	promote	VBZ
cord-336510-qzm9wgde	319	14	production	production	NN
cord-336510-qzm9wgde	319	15	of	of	IN
cord-336510-qzm9wgde	319	16	the	the	DT
cord-336510-qzm9wgde	319	17	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	319	18	cytokines	cytokine	NNS
cord-336510-qzm9wgde	319	19	IL-1	IL-1	NNP
cord-336510-qzm9wgde	319	20	,	,	,
cord-336510-qzm9wgde	319	21	IL-6	IL-6	NNP
cord-336510-qzm9wgde	319	22	,	,	,
cord-336510-qzm9wgde	319	23	and	and	CC
cord-336510-qzm9wgde	319	24	TNF	TNF	NNP
cord-336510-qzm9wgde	319	25	[	[	-LRB-
cord-336510-qzm9wgde	319	26	261	261	CD
cord-336510-qzm9wgde	319	27	]	]	-RRB-
cord-336510-qzm9wgde	319	28	.	.	.
cord-336510-qzm9wgde	320	1	IL-27	IL-27	NNP
cord-336510-qzm9wgde	320	2	is	be	VBZ
cord-336510-qzm9wgde	320	3	the	the	DT
cord-336510-qzm9wgde	320	4	newest	new	JJS
cord-336510-qzm9wgde	320	5	recognized	recognize	VBN
cord-336510-qzm9wgde	320	6	member	member	NN
cord-336510-qzm9wgde	320	7	of	of	IN
cord-336510-qzm9wgde	320	8	the	the	DT
cord-336510-qzm9wgde	320	9	family	family	NN
cord-336510-qzm9wgde	320	10	,	,	,
cord-336510-qzm9wgde	320	11	constructed	construct	VBN
cord-336510-qzm9wgde	320	12	of	of	IN
cord-336510-qzm9wgde	320	13	two	two	CD
cord-336510-qzm9wgde	320	14	distinct	distinct	JJ
cord-336510-qzm9wgde	320	15	subunits	subunit	NNS
cord-336510-qzm9wgde	320	16	(	(	-LRB-
cord-336510-qzm9wgde	320	17	EBI3	EBI3	NNP
cord-336510-qzm9wgde	320	18	and	and	CC
cord-336510-qzm9wgde	320	19	p28	p28	CD
cord-336510-qzm9wgde	320	20	)	)	-RRB-
cord-336510-qzm9wgde	320	21	,	,	,
cord-336510-qzm9wgde	320	22	but	but	CC
cord-336510-qzm9wgde	320	23	still	still	RB
cord-336510-qzm9wgde	320	24	with	with	IN
cord-336510-qzm9wgde	320	25	functional	functional	JJ
cord-336510-qzm9wgde	320	26	capacities	capacity	NNS
cord-336510-qzm9wgde	320	27	alike	alike	RB
cord-336510-qzm9wgde	320	28	those	those	DT
cord-336510-qzm9wgde	320	29	of	of	IN
cord-336510-qzm9wgde	320	30	IL-12	IL-12	NNP
cord-336510-qzm9wgde	320	31	[	[	-LRB-
cord-336510-qzm9wgde	320	32	262	262	CD
cord-336510-qzm9wgde	320	33	]	]	-RRB-
cord-336510-qzm9wgde	320	34	.	.	.
cord-336510-qzm9wgde	321	1	The	the	DT
cord-336510-qzm9wgde	321	2	functional	functional	JJ
cord-336510-qzm9wgde	321	3	implications	implication	NNS
cord-336510-qzm9wgde	321	4	of	of	IN
cord-336510-qzm9wgde	321	5	these	these	DT
cord-336510-qzm9wgde	321	6	later	later	RB
cord-336510-qzm9wgde	321	7	discovered	discover	VBN
cord-336510-qzm9wgde	321	8	members	member	NNS
cord-336510-qzm9wgde	321	9	of	of	IN
cord-336510-qzm9wgde	321	10	the	the	DT
cord-336510-qzm9wgde	321	11	IL-12	IL-12	NNP
cord-336510-qzm9wgde	321	12	family	family	NN
cord-336510-qzm9wgde	321	13	is	be	VBZ
cord-336510-qzm9wgde	321	14	not	not	RB
cord-336510-qzm9wgde	321	15	yet	yet	RB
cord-336510-qzm9wgde	321	16	clear	clear	JJ
cord-336510-qzm9wgde	321	17	,	,	,
cord-336510-qzm9wgde	321	18	but	but	CC
cord-336510-qzm9wgde	321	19	it	-PRON-	PRP
cord-336510-qzm9wgde	321	20	seems	seem	VBZ
cord-336510-qzm9wgde	321	21	as	as	IN
cord-336510-qzm9wgde	321	22	if	if	IN
cord-336510-qzm9wgde	321	23	they	-PRON-	PRP
cord-336510-qzm9wgde	321	24	are	be	VBP
cord-336510-qzm9wgde	321	25	contributors	contributor	NNS
cord-336510-qzm9wgde	321	26	to	to	IN
cord-336510-qzm9wgde	321	27	the	the	DT
cord-336510-qzm9wgde	321	28	overall	overall	JJ
cord-336510-qzm9wgde	321	29	effects	effect	NNS
cord-336510-qzm9wgde	321	30	of	of	IN
cord-336510-qzm9wgde	321	31	the	the	DT
cord-336510-qzm9wgde	321	32	IL-12	IL-12	NNP
cord-336510-qzm9wgde	321	33	family	family	NN
cord-336510-qzm9wgde	321	34	and	and	CC
cord-336510-qzm9wgde	321	35	fine	fine	JJ
cord-336510-qzm9wgde	321	36	-	-	HYPH
cord-336510-qzm9wgde	321	37	tune	tune	VB
cord-336510-qzm9wgde	321	38	the	the	DT
cord-336510-qzm9wgde	321	39	system	system	NN
cord-336510-qzm9wgde	321	40	[	[	-LRB-
cord-336510-qzm9wgde	321	41	235	235	CD
cord-336510-qzm9wgde	321	42	,	,	,
cord-336510-qzm9wgde	321	43	[	[	-LRB-
cord-336510-qzm9wgde	321	44	263	263	CD
cord-336510-qzm9wgde	321	45	]	]	-RRB-
cord-336510-qzm9wgde	321	46	[	[	-LRB-
cord-336510-qzm9wgde	321	47	264	264	CD
cord-336510-qzm9wgde	321	48	]	]	-RRB-
cord-336510-qzm9wgde	321	49	[	[	-LRB-
cord-336510-qzm9wgde	321	50	265	265	CD
cord-336510-qzm9wgde	321	51	]	]	-RRB-
cord-336510-qzm9wgde	321	52	[	[	-LRB-
cord-336510-qzm9wgde	321	53	266	266	CD
cord-336510-qzm9wgde	321	54	]	]	-RRB-
cord-336510-qzm9wgde	321	55	.	.	.
cord-336510-qzm9wgde	322	1	The	the	DT
cord-336510-qzm9wgde	322	2	induction	induction	NN
cord-336510-qzm9wgde	322	3	of	of	IN
cord-336510-qzm9wgde	322	4	IFN	IFN	NNP
cord-336510-qzm9wgde	322	5	-	-	HYPH
cord-336510-qzm9wgde	322	6	γ	γ	NNP
cord-336510-qzm9wgde	322	7	and	and	CC
cord-336510-qzm9wgde	322	8	activation	activation	NN
cord-336510-qzm9wgde	322	9	of	of	IN
cord-336510-qzm9wgde	322	10	NK	NK	NNP
cord-336510-qzm9wgde	322	11	cells	cell	NNS
cord-336510-qzm9wgde	322	12	is	be	VBZ
cord-336510-qzm9wgde	322	13	not	not	RB
cord-336510-qzm9wgde	322	14	only	only	RB
cord-336510-qzm9wgde	322	15	mastered	master	VBN
cord-336510-qzm9wgde	322	16	by	by	IN
cord-336510-qzm9wgde	322	17	members	member	NNS
cord-336510-qzm9wgde	322	18	of	of	IN
cord-336510-qzm9wgde	322	19	the	the	DT
cord-336510-qzm9wgde	322	20	IL-12	IL-12	NNP
cord-336510-qzm9wgde	322	21	cytokine	cytokine	NN
cord-336510-qzm9wgde	322	22	family	family	NN
cord-336510-qzm9wgde	322	23	.	.	.
cord-336510-qzm9wgde	323	1	Other	other	JJ
cord-336510-qzm9wgde	323	2	cytokines	cytokine	NNS
cord-336510-qzm9wgde	323	3	,	,	,
cord-336510-qzm9wgde	323	4	like	like	IN
cord-336510-qzm9wgde	323	5	IL-15	IL-15	NNP
cord-336510-qzm9wgde	323	6	,	,	,
cord-336510-qzm9wgde	323	7	are	be	VBP
cord-336510-qzm9wgde	323	8	also	also	RB
cord-336510-qzm9wgde	323	9	implicated	implicate	VBN
cord-336510-qzm9wgde	323	10	in	in	IN
cord-336510-qzm9wgde	323	11	development	development	NN
cord-336510-qzm9wgde	323	12	,	,	,
cord-336510-qzm9wgde	323	13	function	function	NN
cord-336510-qzm9wgde	323	14	,	,	,
cord-336510-qzm9wgde	323	15	and	and	CC
cord-336510-qzm9wgde	323	16	activation	activation	NN
cord-336510-qzm9wgde	323	17	of	of	IN
cord-336510-qzm9wgde	323	18	these	these	DT
cord-336510-qzm9wgde	323	19	cells	cell	NNS
cord-336510-qzm9wgde	323	20	[	[	-LRB-
cord-336510-qzm9wgde	323	21	267	267	CD
cord-336510-qzm9wgde	323	22	,	,	,
cord-336510-qzm9wgde	323	23	268	268	CD
cord-336510-qzm9wgde	323	24	]	]	-RRB-
cord-336510-qzm9wgde	323	25	.	.	.
cord-336510-qzm9wgde	324	1	Generally	generally	RB
cord-336510-qzm9wgde	324	2	,	,	,
cord-336510-qzm9wgde	324	3	the	the	DT
cord-336510-qzm9wgde	324	4	IL-12	IL-12	NNP
cord-336510-qzm9wgde	324	5	cytokine	cytokine	NN
cord-336510-qzm9wgde	324	6	family	family	NN
cord-336510-qzm9wgde	324	7	has	have	VBZ
cord-336510-qzm9wgde	324	8	shown	show	VBN
cord-336510-qzm9wgde	324	9	itself	-PRON-	PRP
cord-336510-qzm9wgde	324	10	of	of	IN
cord-336510-qzm9wgde	324	11	importance	importance	NN
cord-336510-qzm9wgde	324	12	in	in	IN
cord-336510-qzm9wgde	324	13	early	early	JJ
cord-336510-qzm9wgde	324	14	defence	defence	NN
cord-336510-qzm9wgde	324	15	against	against	IN
cord-336510-qzm9wgde	324	16	several	several	JJ
cord-336510-qzm9wgde	324	17	viral	viral	JJ
cord-336510-qzm9wgde	324	18	infections	infection	NNS
cord-336510-qzm9wgde	324	19	,	,	,
cord-336510-qzm9wgde	324	20	and	and	CC
cord-336510-qzm9wgde	324	21	as	as	IN
cord-336510-qzm9wgde	324	22	a	a	DT
cord-336510-qzm9wgde	324	23	vital	vital	JJ
cord-336510-qzm9wgde	324	24	inducer	inducer	NN
cord-336510-qzm9wgde	324	25	and	and	CC
cord-336510-qzm9wgde	324	26	regulator	regulator	NN
cord-336510-qzm9wgde	324	27	of	of	IN
cord-336510-qzm9wgde	324	28	the	the	DT
cord-336510-qzm9wgde	324	29	adaptive	adaptive	JJ
cord-336510-qzm9wgde	324	30	immune	immune	JJ
cord-336510-qzm9wgde	324	31	response	response	NN
cord-336510-qzm9wgde	324	32	against	against	IN
cord-336510-qzm9wgde	324	33	viruses	virus	NNS
cord-336510-qzm9wgde	324	34	and	and	CC
cord-336510-qzm9wgde	324	35	other	other	JJ
cord-336510-qzm9wgde	324	36	intracellular	intracellular	JJ
cord-336510-qzm9wgde	324	37	pathogens	pathogen	NNS
cord-336510-qzm9wgde	324	38	[	[	-LRB-
cord-336510-qzm9wgde	324	39	219	219	CD
cord-336510-qzm9wgde	324	40	,	,	,
cord-336510-qzm9wgde	324	41	256	256	CD
cord-336510-qzm9wgde	324	42	,	,	,
cord-336510-qzm9wgde	324	43	261	261	CD
cord-336510-qzm9wgde	324	44	,	,	,
cord-336510-qzm9wgde	324	45	269	269	CD
cord-336510-qzm9wgde	324	46	]	]	-RRB-
cord-336510-qzm9wgde	324	47	.	.	.
cord-336510-qzm9wgde	325	1	Upon	upon	IN
cord-336510-qzm9wgde	325	2	an	an	DT
cord-336510-qzm9wgde	325	3	accelerating	accelerate	VBG
cord-336510-qzm9wgde	325	4	pro	pro	JJ
cord-336510-qzm9wgde	325	5	-	-	JJ
cord-336510-qzm9wgde	325	6	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	325	7	response	response	NN
cord-336510-qzm9wgde	325	8	induced	induce	VBN
cord-336510-qzm9wgde	325	9	by	by	IN
cord-336510-qzm9wgde	325	10	initial	initial	JJ
cord-336510-qzm9wgde	325	11	viral	viral	JJ
cord-336510-qzm9wgde	325	12	replication	replication	NN
cord-336510-qzm9wgde	325	13	the	the	DT
cord-336510-qzm9wgde	325	14	organism	organism	NN
cord-336510-qzm9wgde	325	15	has	have	VBZ
cord-336510-qzm9wgde	325	16	to	to	TO
cord-336510-qzm9wgde	325	17	embank	embank	VB
cord-336510-qzm9wgde	325	18	the	the	DT
cord-336510-qzm9wgde	325	19	IFN	IFN	NNP
cord-336510-qzm9wgde	325	20	-	-	HYPH
cord-336510-qzm9wgde	325	21	γ	γ	NNP
cord-336510-qzm9wgde	325	22	-	-	HYPH
cord-336510-qzm9wgde	325	23	activated	activate	VBN
cord-336510-qzm9wgde	325	24	potentially	potentially	RB
cord-336510-qzm9wgde	325	25	harmful	harmful	JJ
cord-336510-qzm9wgde	325	26	actions	action	NNS
cord-336510-qzm9wgde	325	27	of	of	IN
cord-336510-qzm9wgde	325	28	macrophages	macrophage	NNS
cord-336510-qzm9wgde	325	29	and	and	CC
cord-336510-qzm9wgde	325	30	NK	NK	NNP
cord-336510-qzm9wgde	325	31	cells	cell	NNS
cord-336510-qzm9wgde	325	32	.	.	.
cord-336510-qzm9wgde	326	1	Important	important	JJ
cord-336510-qzm9wgde	326	2	mediators	mediator	NNS
cord-336510-qzm9wgde	326	3	of	of	IN
cord-336510-qzm9wgde	326	4	this	this	DT
cord-336510-qzm9wgde	326	5	embankment	embankment	NN
cord-336510-qzm9wgde	326	6	are	be	VBP
cord-336510-qzm9wgde	326	7	IL-4	IL-4	NNP
cord-336510-qzm9wgde	326	8	and	and	CC
cord-336510-qzm9wgde	326	9	IL-13	IL-13	NNP
cord-336510-qzm9wgde	326	10	,	,	,
cord-336510-qzm9wgde	326	11	which	which	WDT
cord-336510-qzm9wgde	326	12	as	as	IN
cord-336510-qzm9wgde	326	13	described	describe	VBN
cord-336510-qzm9wgde	326	14	above	above	IN
cord-336510-qzm9wgde	326	15	repress	repress	VB
cord-336510-qzm9wgde	326	16	the	the	DT
cord-336510-qzm9wgde	326	17	induction	induction	NN
cord-336510-qzm9wgde	326	18	of	of	IN
cord-336510-qzm9wgde	326	19	IL-12	IL-12	NNP
cord-336510-qzm9wgde	326	20	,	,	,
cord-336510-qzm9wgde	326	21	and	and	CC
cord-336510-qzm9wgde	326	22	thus	thus	RB
cord-336510-qzm9wgde	326	23	put	put	VB
cord-336510-qzm9wgde	326	24	a	a	DT
cord-336510-qzm9wgde	326	25	brake	brake	NN
cord-336510-qzm9wgde	326	26	on	on	IN
cord-336510-qzm9wgde	326	27	the	the	DT
cord-336510-qzm9wgde	326	28	positive	positive	JJ
cord-336510-qzm9wgde	326	29	feed	feed	NN
cord-336510-qzm9wgde	326	30	-	-	HYPH
cord-336510-qzm9wgde	326	31	back	back	NN
cord-336510-qzm9wgde	326	32	loop	loop	NN
cord-336510-qzm9wgde	326	33	of	of	IN
cord-336510-qzm9wgde	326	34	IFN	IFN	NNP
cord-336510-qzm9wgde	326	35	-	-	HYPH
cord-336510-qzm9wgde	326	36	γ	γ	NN
cord-336510-qzm9wgde	326	37	production	production	NN
cord-336510-qzm9wgde	326	38	[	[	-LRB-
cord-336510-qzm9wgde	326	39	249	249	CD
cord-336510-qzm9wgde	326	40	,	,	,
cord-336510-qzm9wgde	326	41	252	252	CD
cord-336510-qzm9wgde	326	42	]	]	-RRB-
cord-336510-qzm9wgde	326	43	.	.	.
cord-336510-qzm9wgde	327	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	327	2	,	,	,
cord-336510-qzm9wgde	327	3	IL-4	IL-4	NNP
cord-336510-qzm9wgde	327	4	suppresses	suppress	VBZ
cord-336510-qzm9wgde	327	5	the	the	DT
cord-336510-qzm9wgde	327	6	production	production	NN
cord-336510-qzm9wgde	327	7	of	of	IN
cord-336510-qzm9wgde	327	8	other	other	JJ
cord-336510-qzm9wgde	327	9	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	327	10	cytokines	cytokine	NNS
cord-336510-qzm9wgde	327	11	such	such	JJ
cord-336510-qzm9wgde	327	12	as	as	IN
cord-336510-qzm9wgde	327	13	TNF	TNF	NNP
cord-336510-qzm9wgde	327	14	and	and	CC
cord-336510-qzm9wgde	327	15	IL-1	IL-1	NNP
cord-336510-qzm9wgde	327	16	[	[	-LRB-
cord-336510-qzm9wgde	327	17	270	270	CD
cord-336510-qzm9wgde	327	18	]	]	-RRB-
cord-336510-qzm9wgde	327	19	.	.	.
cord-336510-qzm9wgde	328	1	Most	most	RBS
cord-336510-qzm9wgde	328	2	importantly	importantly	RB
cord-336510-qzm9wgde	328	3	,	,	,
cord-336510-qzm9wgde	328	4	IL-4	IL-4	NNP
cord-336510-qzm9wgde	328	5	and	and	CC
cord-336510-qzm9wgde	328	6	IL-13	IL-13	NNP
cord-336510-qzm9wgde	328	7	are	be	VBP
cord-336510-qzm9wgde	328	8	potent	potent	JJ
cord-336510-qzm9wgde	328	9	inhibitors	inhibitor	NNS
cord-336510-qzm9wgde	328	10	of	of	IN
cord-336510-qzm9wgde	328	11	the	the	DT
cord-336510-qzm9wgde	328	12	efferent	efferent	JJ
cord-336510-qzm9wgde	328	13	arm	arm	NN
cord-336510-qzm9wgde	328	14	of	of	IN
cord-336510-qzm9wgde	328	15	the	the	DT
cord-336510-qzm9wgde	328	16	pro	pro	JJ
cord-336510-qzm9wgde	328	17	-	-	JJ
cord-336510-qzm9wgde	328	18	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	328	19	system	system	NN
cord-336510-qzm9wgde	328	20	,	,	,
cord-336510-qzm9wgde	328	21	and	and	CC
cord-336510-qzm9wgde	328	22	thus	thus	RB
cord-336510-qzm9wgde	328	23	inhibit	inhibit	VB
cord-336510-qzm9wgde	328	24	production	production	NN
cord-336510-qzm9wgde	328	25	of	of	IN
cord-336510-qzm9wgde	328	26	reactive	reactive	JJ
cord-336510-qzm9wgde	328	27	oxygen	oxygen	NN
cord-336510-qzm9wgde	328	28	species	specie	NNS
cord-336510-qzm9wgde	328	29	and	and	CC
cord-336510-qzm9wgde	328	30	nitric	nitric	NN
cord-336510-qzm9wgde	328	31	oxide	oxide	NN
cord-336510-qzm9wgde	328	32	.	.	.
cord-336510-qzm9wgde	329	1	The	the	DT
cord-336510-qzm9wgde	329	2	production	production	NN
cord-336510-qzm9wgde	329	3	of	of	IN
cord-336510-qzm9wgde	329	4	these	these	DT
cord-336510-qzm9wgde	329	5	two	two	CD
cord-336510-qzm9wgde	329	6	potentially	potentially	RB
cord-336510-qzm9wgde	329	7	harmful	harmful	JJ
cord-336510-qzm9wgde	329	8	effector	effector	NN
cord-336510-qzm9wgde	329	9	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	329	10	of	of	IN
cord-336510-qzm9wgde	329	11	activated	activate	VBN
cord-336510-qzm9wgde	329	12	macrophages	macrophage	NNS
cord-336510-qzm9wgde	329	13	is	be	VBZ
cord-336510-qzm9wgde	329	14	hampered	hamper	VBN
cord-336510-qzm9wgde	329	15	by	by	IN
cord-336510-qzm9wgde	329	16	inhibition	inhibition	NN
cord-336510-qzm9wgde	329	17	of	of	IN
cord-336510-qzm9wgde	329	18	production	production	NN
cord-336510-qzm9wgde	329	19	of	of	IN
cord-336510-qzm9wgde	329	20	the	the	DT
cord-336510-qzm9wgde	329	21	responsible	responsible	JJ
cord-336510-qzm9wgde	329	22	enzymes	enzyme	NNS
cord-336510-qzm9wgde	329	23	in	in	IN
cord-336510-qzm9wgde	329	24	these	these	DT
cord-336510-qzm9wgde	329	25	reactions	reaction	NNS
cord-336510-qzm9wgde	329	26	,	,	,
cord-336510-qzm9wgde	329	27	the	the	DT
cord-336510-qzm9wgde	329	28	NADPH	NADPH	NNP
cord-336510-qzm9wgde	329	29	oxidase	oxidase	NN
cord-336510-qzm9wgde	329	30	and	and	CC
cord-336510-qzm9wgde	329	31	the	the	DT
cord-336510-qzm9wgde	329	32	inducible	inducible	JJ
cord-336510-qzm9wgde	329	33	nitric	nitric	NN
cord-336510-qzm9wgde	329	34	oxide	oxide	NN
cord-336510-qzm9wgde	329	35	synthase	synthase	NN
cord-336510-qzm9wgde	329	36	(	(	-LRB-
cord-336510-qzm9wgde	329	37	iNOS	inos	NN
cord-336510-qzm9wgde	329	38	)	)	-RRB-
cord-336510-qzm9wgde	329	39	[	[	-LRB-
cord-336510-qzm9wgde	329	40	271	271	CD
cord-336510-qzm9wgde	329	41	]	]	-RRB-
cord-336510-qzm9wgde	329	42	[	[	-LRB-
cord-336510-qzm9wgde	329	43	272	272	CD
cord-336510-qzm9wgde	329	44	]	]	-RRB-
cord-336510-qzm9wgde	329	45	[	[	-LRB-
cord-336510-qzm9wgde	329	46	273	273	CD
cord-336510-qzm9wgde	329	47	]	]	-RRB-
cord-336510-qzm9wgde	329	48	.	.	.
cord-336510-qzm9wgde	330	1	The	the	DT
cord-336510-qzm9wgde	330	2	primary	primary	JJ
cord-336510-qzm9wgde	330	3	producer	producer	NN
cord-336510-qzm9wgde	330	4	cells	cell	NNS
cord-336510-qzm9wgde	330	5	of	of	IN
cord-336510-qzm9wgde	330	6	IL-4	IL-4	NNP
cord-336510-qzm9wgde	330	7	and	and	CC
cord-336510-qzm9wgde	330	8	IL-13	IL-13	NNP
cord-336510-qzm9wgde	330	9	are	be	VBP
cord-336510-qzm9wgde	330	10	the	the	DT
cord-336510-qzm9wgde	330	11	Th2	th2	CD
cord-336510-qzm9wgde	330	12	cells	cell	NNS
cord-336510-qzm9wgde	330	13	,	,	,
cord-336510-qzm9wgde	330	14	but	but	CC
cord-336510-qzm9wgde	330	15	these	these	DT
cord-336510-qzm9wgde	330	16	cytokines	cytokine	NNS
cord-336510-qzm9wgde	330	17	are	be	VBP
cord-336510-qzm9wgde	330	18	also	also	RB
cord-336510-qzm9wgde	330	19	produced	produce	VBN
cord-336510-qzm9wgde	330	20	by	by	IN
cord-336510-qzm9wgde	330	21	basophils	basophil	NNS
cord-336510-qzm9wgde	330	22	and	and	CC
cord-336510-qzm9wgde	330	23	mast	mast	NN
cord-336510-qzm9wgde	330	24	cells	cell	NNS
cord-336510-qzm9wgde	330	25	[	[	-LRB-
cord-336510-qzm9wgde	330	26	274	274	CD
cord-336510-qzm9wgde	330	27	]	]	-RRB-
cord-336510-qzm9wgde	330	28	[	[	-LRB-
cord-336510-qzm9wgde	330	29	275	275	CD
cord-336510-qzm9wgde	330	30	]	]	-RRB-
cord-336510-qzm9wgde	330	31	[	[	-LRB-
cord-336510-qzm9wgde	330	32	276	276	CD
cord-336510-qzm9wgde	330	33	]	]	-RRB-
cord-336510-qzm9wgde	330	34	.	.	.
cord-336510-qzm9wgde	331	1	The	the	DT
cord-336510-qzm9wgde	331	2	receptors	receptor	NNS
cord-336510-qzm9wgde	331	3	for	for	IN
cord-336510-qzm9wgde	331	4	IL-4	IL-4	NNP
cord-336510-qzm9wgde	331	5	and	and	CC
cord-336510-qzm9wgde	331	6	IL-13	IL-13	NNP
cord-336510-qzm9wgde	331	7	are	be	VBP
cord-336510-qzm9wgde	331	8	expressed	express	VBN
cord-336510-qzm9wgde	331	9	on	on	IN
cord-336510-qzm9wgde	331	10	most	most	JJS
cord-336510-qzm9wgde	331	11	cells	cell	NNS
cord-336510-qzm9wgde	331	12	and	and	CC
cord-336510-qzm9wgde	331	13	are	be	VBP
cord-336510-qzm9wgde	331	14	composed	compose	VBN
cord-336510-qzm9wgde	331	15	as	as	IN
cord-336510-qzm9wgde	331	16	dimers	dimer	NNS
cord-336510-qzm9wgde	331	17	of	of	IN
cord-336510-qzm9wgde	331	18	four	four	CD
cord-336510-qzm9wgde	331	19	different	different	JJ
cord-336510-qzm9wgde	331	20	chains	chain	NNS
cord-336510-qzm9wgde	331	21	.	.	.
cord-336510-qzm9wgde	332	1	IL-4	IL-4	NNP
cord-336510-qzm9wgde	332	2	is	be	VBZ
cord-336510-qzm9wgde	332	3	the	the	DT
cord-336510-qzm9wgde	332	4	ligand	ligand	NN
cord-336510-qzm9wgde	332	5	of	of	IN
cord-336510-qzm9wgde	332	6	two	two	CD
cord-336510-qzm9wgde	332	7	receptors	receptor	NNS
cord-336510-qzm9wgde	332	8	:	:	:
cord-336510-qzm9wgde	333	1	A	a	DT
cord-336510-qzm9wgde	333	2	high	high	JJ
cord-336510-qzm9wgde	333	3	-	-	HYPH
cord-336510-qzm9wgde	333	4	affinity	affinity	NN
cord-336510-qzm9wgde	333	5	heterodimer	heterodimer	NN
cord-336510-qzm9wgde	333	6	of	of	IN
cord-336510-qzm9wgde	333	7	IL-4Rα	IL-4Rα	NNP
cord-336510-qzm9wgde	333	8	and	and	CC
cord-336510-qzm9wgde	333	9	the	the	DT
cord-336510-qzm9wgde	333	10	IL-2R	IL-2R	NNP
cord-336510-qzm9wgde	333	11	common	common	JJ
cord-336510-qzm9wgde	333	12	γ	γ	NN
cord-336510-qzm9wgde	333	13	-	-	HYPH
cord-336510-qzm9wgde	333	14	chain	chain	NN
cord-336510-qzm9wgde	333	15	and	and	CC
cord-336510-qzm9wgde	333	16	another	another	DT
cord-336510-qzm9wgde	333	17	heterodimeric	heterodimeric	JJ
cord-336510-qzm9wgde	333	18	receptor	receptor	NN
cord-336510-qzm9wgde	333	19	composed	compose	VBN
cord-336510-qzm9wgde	333	20	of	of	IN
cord-336510-qzm9wgde	333	21	IL-4Rα	IL-4Rα	NNP
cord-336510-qzm9wgde	333	22	and	and	CC
cord-336510-qzm9wgde	333	23	IL-13Rα1	IL-13Rα1	NNP
cord-336510-qzm9wgde	333	24	.	.	.
cord-336510-qzm9wgde	334	1	IL-13	IL-13	NNP
cord-336510-qzm9wgde	334	2	binds	bind	VBZ
cord-336510-qzm9wgde	334	3	to	to	IN
cord-336510-qzm9wgde	334	4	three	three	CD
cord-336510-qzm9wgde	334	5	complexes	complex	NNS
cord-336510-qzm9wgde	334	6	:	:	:
cord-336510-qzm9wgde	335	1	A	a	DT
cord-336510-qzm9wgde	335	2	high	high	JJ
cord-336510-qzm9wgde	335	3	-	-	HYPH
cord-336510-qzm9wgde	335	4	affinity	affinity	NN
cord-336510-qzm9wgde	335	5	heterodimer	heterodimer	NN
cord-336510-qzm9wgde	335	6	of	of	IN
cord-336510-qzm9wgde	335	7	IL-13Rα	il-13rα	CD
cord-336510-qzm9wgde	336	1	and	and	CC
cord-336510-qzm9wgde	336	2	IL-4Rα	IL-4Rα	NNP
cord-336510-qzm9wgde	336	3	and	and	CC
cord-336510-qzm9wgde	336	4	two	two	CD
cord-336510-qzm9wgde	336	5	homodimers	homodimer	NNS
cord-336510-qzm9wgde	336	6	composed	compose	VBN
cord-336510-qzm9wgde	336	7	of	of	IN
cord-336510-qzm9wgde	336	8	either	either	CC
cord-336510-qzm9wgde	336	9	IL-13Rα1	IL-13Rα1	NNP
cord-336510-qzm9wgde	336	10	or	or	CC
cord-336510-qzm9wgde	336	11	IL-13Rα2	IL-13Rα2	NNPS
cord-336510-qzm9wgde	336	12	,	,	,
cord-336510-qzm9wgde	336	13	which	which	WDT
cord-336510-qzm9wgde	336	14	are	be	VBP
cord-336510-qzm9wgde	336	15	both	both	DT
cord-336510-qzm9wgde	336	16	coded	code	VBN
cord-336510-qzm9wgde	336	17	from	from	IN
cord-336510-qzm9wgde	336	18	genes	gene	NNS
cord-336510-qzm9wgde	336	19	on	on	IN
cord-336510-qzm9wgde	336	20	the	the	DT
cord-336510-qzm9wgde	336	21	human	human	JJ
cord-336510-qzm9wgde	336	22	X	x	NN
cord-336510-qzm9wgde	336	23	-	-	NN
cord-336510-qzm9wgde	336	24	chromosome	chromosome	NN
cord-336510-qzm9wgde	336	25	[	[	-LRB-
cord-336510-qzm9wgde	336	26	276	276	CD
cord-336510-qzm9wgde	336	27	]	]	-RRB-
cord-336510-qzm9wgde	336	28	.	.	.
cord-336510-qzm9wgde	337	1	The	the	DT
cord-336510-qzm9wgde	337	2	immunomodulatory	immunomodulatory	JJ
cord-336510-qzm9wgde	337	3	signalling	signalling	NN
cord-336510-qzm9wgde	337	4	is	be	VBZ
cord-336510-qzm9wgde	337	5	conducted	conduct	VBN
cord-336510-qzm9wgde	337	6	through	through	IN
cord-336510-qzm9wgde	337	7	the	the	DT
cord-336510-qzm9wgde	337	8	JAK	JAK	NNP
cord-336510-qzm9wgde	337	9	/	/	SYM
cord-336510-qzm9wgde	337	10	STAT	stat	NN
cord-336510-qzm9wgde	337	11	-	-	HYPH
cord-336510-qzm9wgde	337	12	pathway	pathway	NN
cord-336510-qzm9wgde	337	13	utilizing	utilize	VBG
cord-336510-qzm9wgde	337	14	JAK1	JAK1	NNP
cord-336510-qzm9wgde	337	15	,	,	,
cord-336510-qzm9wgde	337	16	JAK3	JAK3	NNP
cord-336510-qzm9wgde	337	17	and	and	CC
cord-336510-qzm9wgde	337	18	STAT6	STAT6	NNP
cord-336510-qzm9wgde	337	19	.	.	.
cord-336510-qzm9wgde	338	1	Phosphorylated	phosphorylated	JJ
cord-336510-qzm9wgde	338	2	and	and	CC
cord-336510-qzm9wgde	338	3	homodimerized	homodimerize	VBD
cord-336510-qzm9wgde	338	4	STAT6	stat6	NN
cord-336510-qzm9wgde	338	5	binds	bind	VBZ
cord-336510-qzm9wgde	338	6	to	to	IN
cord-336510-qzm9wgde	338	7	STAT	stat	NN
cord-336510-qzm9wgde	338	8	binding	bind	VBG
cord-336510-qzm9wgde	338	9	elements	element	NNS
cord-336510-qzm9wgde	338	10	(	(	-LRB-
cord-336510-qzm9wgde	338	11	SBE	SBE	NNP
cord-336510-qzm9wgde	338	12	)	)	-RRB-
cord-336510-qzm9wgde	338	13	,	,	,
cord-336510-qzm9wgde	338	14	which	which	WDT
cord-336510-qzm9wgde	338	15	includes	include	VBZ
cord-336510-qzm9wgde	338	16	GAS	gas	NN
cord-336510-qzm9wgde	338	17	,	,	,
cord-336510-qzm9wgde	338	18	and	and	CC
cord-336510-qzm9wgde	338	19	either	either	DT
cord-336510-qzm9wgde	338	20	trans	trans	NNP
cord-336510-qzm9wgde	338	21	-	-	VBZ
cord-336510-qzm9wgde	338	22	activates	activate	NNS
cord-336510-qzm9wgde	338	23	or	or	CC
cord-336510-qzm9wgde	338	24	inhibits	inhibit	VBZ
cord-336510-qzm9wgde	338	25	transcription	transcription	NN
cord-336510-qzm9wgde	338	26	of	of	IN
cord-336510-qzm9wgde	338	27	the	the	DT
cord-336510-qzm9wgde	338	28	adjacent	adjacent	JJ
cord-336510-qzm9wgde	338	29	genes	gene	NNS
cord-336510-qzm9wgde	338	30	[	[	-LRB-
cord-336510-qzm9wgde	338	31	212	212	CD
cord-336510-qzm9wgde	338	32	]	]	-RRB-
cord-336510-qzm9wgde	338	33	.	.	.
cord-336510-qzm9wgde	339	1	The	the	DT
cord-336510-qzm9wgde	339	2	functions	function	NNS
cord-336510-qzm9wgde	339	3	of	of	IN
cord-336510-qzm9wgde	339	4	IL-4	IL-4	NNP
cord-336510-qzm9wgde	339	5	and	and	CC
cord-336510-qzm9wgde	339	6	IL-13	IL-13	NNP
cord-336510-qzm9wgde	339	7	are	be	VBP
cord-336510-qzm9wgde	339	8	nearly	nearly	RB
cord-336510-qzm9wgde	339	9	overlapping	overlap	VBG
cord-336510-qzm9wgde	339	10	with	with	IN
cord-336510-qzm9wgde	339	11	only	only	JJ
cord-336510-qzm9wgde	339	12	discreet	discreet	JJ
cord-336510-qzm9wgde	339	13	discrepancies	discrepancy	NNS
cord-336510-qzm9wgde	339	14	[	[	-LRB-
cord-336510-qzm9wgde	339	15	276	276	CD
cord-336510-qzm9wgde	339	16	,	,	,
cord-336510-qzm9wgde	339	17	277	277	CD
cord-336510-qzm9wgde	339	18	]	]	-RRB-
cord-336510-qzm9wgde	339	19	.	.	.
cord-336510-qzm9wgde	340	1	IL-4	IL-4	NNP
cord-336510-qzm9wgde	340	2	was	be	VBD
cord-336510-qzm9wgde	340	3	discovered	discover	VBN
cord-336510-qzm9wgde	340	4	in	in	IN
cord-336510-qzm9wgde	340	5	1982	1982	CD
cord-336510-qzm9wgde	340	6	on	on	IN
cord-336510-qzm9wgde	340	7	the	the	DT
cord-336510-qzm9wgde	340	8	basis	basis	NN
cord-336510-qzm9wgde	340	9	of	of	IN
cord-336510-qzm9wgde	340	10	another	another	DT
cord-336510-qzm9wgde	340	11	important	important	JJ
cord-336510-qzm9wgde	340	12	effect	effect	NN
cord-336510-qzm9wgde	340	13	of	of	IN
cord-336510-qzm9wgde	340	14	the	the	DT
cord-336510-qzm9wgde	340	15	cytokine	cytokine	NN
cord-336510-qzm9wgde	340	16	,	,	,
cord-336510-qzm9wgde	340	17	namely	namely	RB
cord-336510-qzm9wgde	340	18	the	the	DT
cord-336510-qzm9wgde	340	19	ability	ability	NN
cord-336510-qzm9wgde	340	20	to	to	TO
cord-336510-qzm9wgde	340	21	induce	induce	VB
cord-336510-qzm9wgde	340	22	proliferation	proliferation	NN
cord-336510-qzm9wgde	340	23	of	of	IN
cord-336510-qzm9wgde	340	24	B	b	NN
cord-336510-qzm9wgde	340	25	cells	cell	NNS
cord-336510-qzm9wgde	340	26	,	,	,
cord-336510-qzm9wgde	340	27	and	and	CC
cord-336510-qzm9wgde	340	28	it	-PRON-	PRP
cord-336510-qzm9wgde	340	29	was	be	VBD
cord-336510-qzm9wgde	340	30	from	from	IN
cord-336510-qzm9wgde	340	31	this	this	DT
cord-336510-qzm9wgde	340	32	effect	effect	NN
cord-336510-qzm9wgde	340	33	in	in	IN
cord-336510-qzm9wgde	340	34	the	the	DT
cord-336510-qzm9wgde	340	35	early	early	JJ
cord-336510-qzm9wgde	340	36	years	year	NNS
cord-336510-qzm9wgde	340	37	called	call	VBD
cord-336510-qzm9wgde	340	38	B	b	NN
cord-336510-qzm9wgde	340	39	cell	cell	NN
cord-336510-qzm9wgde	340	40	growth	growth	NN
cord-336510-qzm9wgde	340	41	factor	factor	NN
cord-336510-qzm9wgde	340	42	[	[	-LRB-
cord-336510-qzm9wgde	340	43	278	278	CD
cord-336510-qzm9wgde	340	44	]	]	-RRB-
cord-336510-qzm9wgde	340	45	.	.	.
cord-336510-qzm9wgde	341	1	As	as	IN
cord-336510-qzm9wgde	341	2	this	this	DT
cord-336510-qzm9wgde	341	3	,	,	,
cord-336510-qzm9wgde	341	4	some	some	DT
cord-336510-qzm9wgde	341	5	other	other	JJ
cord-336510-qzm9wgde	341	6	effects	effect	NNS
cord-336510-qzm9wgde	341	7	of	of	IN
cord-336510-qzm9wgde	341	8	IL-4	IL-4	NNP
cord-336510-qzm9wgde	341	9	are	be	VBP
cord-336510-qzm9wgde	341	10	stimulating	stimulate	VBG
cord-336510-qzm9wgde	341	11	,	,	,
cord-336510-qzm9wgde	341	12	in	in	IN
cord-336510-qzm9wgde	341	13	that	that	IN
cord-336510-qzm9wgde	341	14	it	-PRON-	PRP
cord-336510-qzm9wgde	341	15	furthermore	furthermore	RB
cord-336510-qzm9wgde	341	16	activates	activate	VBZ
cord-336510-qzm9wgde	341	17	other	other	JJ
cord-336510-qzm9wgde	341	18	Th2-like	th2-like	JJ
cord-336510-qzm9wgde	341	19	effects	effect	NNS
cord-336510-qzm9wgde	341	20	such	such	JJ
cord-336510-qzm9wgde	341	21	as	as	IN
cord-336510-qzm9wgde	341	22	B	b	NN
cord-336510-qzm9wgde	341	23	cell	cell	NN
cord-336510-qzm9wgde	341	24	class	class	NN
cord-336510-qzm9wgde	341	25	-	-	HYPH
cord-336510-qzm9wgde	341	26	switching	switching	NN
cord-336510-qzm9wgde	341	27	and	and	CC
cord-336510-qzm9wgde	341	28	expression	expression	NN
cord-336510-qzm9wgde	341	29	of	of	IN
cord-336510-qzm9wgde	341	30	mannose	mannose	NN
cord-336510-qzm9wgde	341	31	receptor	receptor	NN
cord-336510-qzm9wgde	341	32	and	and	CC
cord-336510-qzm9wgde	341	33	Fc	Fc	NNP
cord-336510-qzm9wgde	341	34	receptor	receptor	NN
cord-336510-qzm9wgde	341	35	for	for	IN
cord-336510-qzm9wgde	341	36	IgE	IgE	NNP
cord-336510-qzm9wgde	341	37	on	on	IN
cord-336510-qzm9wgde	341	38	macrophages	macrophage	NNS
cord-336510-qzm9wgde	341	39	[	[	-LRB-
cord-336510-qzm9wgde	341	40	276	276	CD
cord-336510-qzm9wgde	341	41	]	]	-RRB-
cord-336510-qzm9wgde	341	42	.	.	.
cord-336510-qzm9wgde	342	1	Despite	despite	IN
cord-336510-qzm9wgde	342	2	the	the	DT
cord-336510-qzm9wgde	342	3	anti	anti	JJ
cord-336510-qzm9wgde	342	4	-	-	JJ
cord-336510-qzm9wgde	342	5	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	342	6	profile	profile	NN
cord-336510-qzm9wgde	342	7	IL-4	IL-4	NNP
cord-336510-qzm9wgde	342	8	has	have	VBZ
cord-336510-qzm9wgde	342	9	in	in	IN
cord-336510-qzm9wgde	342	10	vivo	vivo	NN
cord-336510-qzm9wgde	342	11	been	be	VBN
cord-336510-qzm9wgde	342	12	shown	show	VBN
cord-336510-qzm9wgde	342	13	to	to	TO
cord-336510-qzm9wgde	342	14	confer	confer	VB
cord-336510-qzm9wgde	342	15	some	some	DT
cord-336510-qzm9wgde	342	16	resistance	resistance	NN
cord-336510-qzm9wgde	342	17	to	to	IN
cord-336510-qzm9wgde	342	18	HSV	HSV	NNP
cord-336510-qzm9wgde	342	19	infection	infection	NN
cord-336510-qzm9wgde	342	20	[	[	-LRB-
cord-336510-qzm9wgde	342	21	279	279	CD
cord-336510-qzm9wgde	342	22	,	,	,
cord-336510-qzm9wgde	342	23	280	280	CD
cord-336510-qzm9wgde	342	24	]	]	-RRB-
cord-336510-qzm9wgde	342	25	.	.	.
cord-336510-qzm9wgde	343	1	IL-4	IL-4	NNP
cord-336510-qzm9wgde	343	2	is	be	VBZ
cord-336510-qzm9wgde	343	3	thus	thus	RB
cord-336510-qzm9wgde	343	4	not	not	RB
cord-336510-qzm9wgde	343	5	only	only	RB
cord-336510-qzm9wgde	343	6	an	an	DT
cord-336510-qzm9wgde	343	7	inhibiting	inhibit	VBG
cord-336510-qzm9wgde	343	8	cytokine	cytokine	NN
cord-336510-qzm9wgde	343	9	but	but	CC
cord-336510-qzm9wgde	343	10	essentially	essentially	RB
cord-336510-qzm9wgde	343	11	an	an	DT
cord-336510-qzm9wgde	343	12	immunomodulatory	immunomodulatory	JJ
cord-336510-qzm9wgde	343	13	cytokine	cytokine	NN
cord-336510-qzm9wgde	343	14	with	with	IN
cord-336510-qzm9wgde	343	15	regulatory	regulatory	JJ
cord-336510-qzm9wgde	343	16	effects	effect	NNS
cord-336510-qzm9wgde	343	17	on	on	IN
cord-336510-qzm9wgde	343	18	macrophages	macrophage	NNS
cord-336510-qzm9wgde	343	19	as	as	RB
cord-336510-qzm9wgde	343	20	well	well	RB
cord-336510-qzm9wgde	343	21	.	.	.
cord-336510-qzm9wgde	344	1	The	the	DT
cord-336510-qzm9wgde	344	2	early	early	JJ
cord-336510-qzm9wgde	344	3	innate	innate	JJ
cord-336510-qzm9wgde	344	4	defence	defence	NN
cord-336510-qzm9wgde	344	5	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	344	6	have	have	VBP
cord-336510-qzm9wgde	344	7	for	for	IN
cord-336510-qzm9wgde	344	8	many	many	JJ
cord-336510-qzm9wgde	344	9	years	year	NNS
cord-336510-qzm9wgde	344	10	been	be	VBN
cord-336510-qzm9wgde	344	11	regarded	regard	VBN
cord-336510-qzm9wgde	344	12	as	as	RB
cord-336510-qzm9wgde	344	13	important	important	JJ
cord-336510-qzm9wgde	344	14	for	for	IN
cord-336510-qzm9wgde	344	15	the	the	DT
cord-336510-qzm9wgde	344	16	course	course	NN
cord-336510-qzm9wgde	344	17	of	of	IN
cord-336510-qzm9wgde	344	18	many	many	JJ
cord-336510-qzm9wgde	344	19	viral	viral	JJ
cord-336510-qzm9wgde	344	20	infections	infection	NNS
cord-336510-qzm9wgde	344	21	,	,	,
cord-336510-qzm9wgde	344	22	including	include	VBG
cord-336510-qzm9wgde	344	23	infections	infection	NNS
cord-336510-qzm9wgde	344	24	with	with	IN
cord-336510-qzm9wgde	344	25	HSV	HSV	NNP
cord-336510-qzm9wgde	344	26	[	[	-LRB-
cord-336510-qzm9wgde	344	27	281	281	CD
cord-336510-qzm9wgde	344	28	]	]	-RRB-
cord-336510-qzm9wgde	344	29	.	.	.
cord-336510-qzm9wgde	345	1	The	the	DT
cord-336510-qzm9wgde	345	2	control	control	NN
cord-336510-qzm9wgde	345	3	of	of	IN
cord-336510-qzm9wgde	345	4	viral	viral	JJ
cord-336510-qzm9wgde	345	5	replication	replication	NN
cord-336510-qzm9wgde	345	6	and	and	CC
cord-336510-qzm9wgde	345	7	dissemination	dissemination	NN
cord-336510-qzm9wgde	345	8	during	during	IN
cord-336510-qzm9wgde	345	9	the	the	DT
cord-336510-qzm9wgde	345	10	first	first	JJ
cord-336510-qzm9wgde	345	11	days	day	NNS
cord-336510-qzm9wgde	345	12	of	of	IN
cord-336510-qzm9wgde	345	13	an	an	DT
cord-336510-qzm9wgde	345	14	HSV	HSV	NNP
cord-336510-qzm9wgde	345	15	infection	infection	NN
cord-336510-qzm9wgde	345	16	seems	seem	VBZ
cord-336510-qzm9wgde	345	17	to	to	TO
cord-336510-qzm9wgde	345	18	be	be	VB
cord-336510-qzm9wgde	345	19	vital	vital	JJ
cord-336510-qzm9wgde	345	20	for	for	IN
cord-336510-qzm9wgde	345	21	the	the	DT
cord-336510-qzm9wgde	345	22	final	final	JJ
cord-336510-qzm9wgde	345	23	outcome	outcome	NN
cord-336510-qzm9wgde	345	24	.	.	.
cord-336510-qzm9wgde	346	1	If	if	IN
cord-336510-qzm9wgde	346	2	the	the	DT
cord-336510-qzm9wgde	346	3	viral	viral	JJ
cord-336510-qzm9wgde	346	4	replication	replication	NN
cord-336510-qzm9wgde	346	5	is	be	VBZ
cord-336510-qzm9wgde	346	6	not	not	RB
cord-336510-qzm9wgde	346	7	halted	halt	VBN
cord-336510-qzm9wgde	346	8	by	by	IN
cord-336510-qzm9wgde	346	9	natural	natural	JJ
cord-336510-qzm9wgde	346	10	defence	defence	NN
cord-336510-qzm9wgde	346	11	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	346	12	during	during	IN
cord-336510-qzm9wgde	346	13	induction	induction	NN
cord-336510-qzm9wgde	346	14	and	and	CC
cord-336510-qzm9wgde	346	15	maturation	maturation	NN
cord-336510-qzm9wgde	346	16	of	of	IN
cord-336510-qzm9wgde	346	17	the	the	DT
cord-336510-qzm9wgde	346	18	antigen	antigen	NN
cord-336510-qzm9wgde	346	19	-	-	HYPH
cord-336510-qzm9wgde	346	20	specific	specific	JJ
cord-336510-qzm9wgde	346	21	immune	immune	JJ
cord-336510-qzm9wgde	346	22	response	response	NN
cord-336510-qzm9wgde	346	23	,	,	,
cord-336510-qzm9wgde	346	24	the	the	DT
cord-336510-qzm9wgde	346	25	adaptive	adaptive	JJ
cord-336510-qzm9wgde	346	26	immune	immune	JJ
cord-336510-qzm9wgde	346	27	system	system	NN
cord-336510-qzm9wgde	346	28	can	can	MD
cord-336510-qzm9wgde	346	29	be	be	VB
cord-336510-qzm9wgde	346	30	overwhelmed	overwhelm	VBN
cord-336510-qzm9wgde	346	31	by	by	IN
cord-336510-qzm9wgde	346	32	massive	massive	JJ
cord-336510-qzm9wgde	346	33	viral	viral	JJ
cord-336510-qzm9wgde	346	34	infection	infection	NN
cord-336510-qzm9wgde	346	35	at	at	IN
cord-336510-qzm9wgde	346	36	the	the	DT
cord-336510-qzm9wgde	346	37	dawn	dawn	NN
cord-336510-qzm9wgde	346	38	of	of	IN
cord-336510-qzm9wgde	346	39	activity	activity	NN
cord-336510-qzm9wgde	346	40	of	of	IN
cord-336510-qzm9wgde	346	41	the	the	DT
cord-336510-qzm9wgde	346	42	specific	specific	JJ
cord-336510-qzm9wgde	346	43	reactions	reaction	NNS
cord-336510-qzm9wgde	346	44	.	.	.
cord-336510-qzm9wgde	347	1	The	the	DT
cord-336510-qzm9wgde	347	2	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	347	3	of	of	IN
cord-336510-qzm9wgde	347	4	the	the	DT
cord-336510-qzm9wgde	347	5	anti	anti	JJ
cord-336510-qzm9wgde	347	6	-	-	JJ
cord-336510-qzm9wgde	347	7	herpetic	herpetic	JJ
cord-336510-qzm9wgde	347	8	natural	natural	JJ
cord-336510-qzm9wgde	347	9	defence	defence	NN
cord-336510-qzm9wgde	347	10	have	have	VBP
cord-336510-qzm9wgde	347	11	been	be	VBN
cord-336510-qzm9wgde	347	12	analysed	analyse	VBN
cord-336510-qzm9wgde	347	13	extensively	extensively	RB
cord-336510-qzm9wgde	347	14	.	.	.
cord-336510-qzm9wgde	348	1	It	-PRON-	PRP
cord-336510-qzm9wgde	348	2	became	become	VBD
cord-336510-qzm9wgde	348	3	relatively	relatively	RB
cord-336510-qzm9wgde	348	4	early	early	RB
cord-336510-qzm9wgde	348	5	clear	clear	JJ
cord-336510-qzm9wgde	348	6	that	that	IN
cord-336510-qzm9wgde	348	7	antiviral	antiviral	JJ
cord-336510-qzm9wgde	348	8	activity	activity	NN
cord-336510-qzm9wgde	348	9	of	of	IN
cord-336510-qzm9wgde	348	10	macrophages	macrophage	NNS
cord-336510-qzm9wgde	348	11	[	[	-LRB-
cord-336510-qzm9wgde	348	12	281	281	CD
cord-336510-qzm9wgde	348	13	]	]	-RRB-
cord-336510-qzm9wgde	348	14	and	and	CC
cord-336510-qzm9wgde	348	15	NK	NK	NNP
cord-336510-qzm9wgde	348	16	cells	cell	NNS
cord-336510-qzm9wgde	348	17	[	[	-LRB-
cord-336510-qzm9wgde	348	18	282	282	CD
cord-336510-qzm9wgde	348	19	]	]	-RRB-
cord-336510-qzm9wgde	348	20	and	and	CC
cord-336510-qzm9wgde	348	21	early	early	JJ
cord-336510-qzm9wgde	348	22	activity	activity	NN
cord-336510-qzm9wgde	348	23	of	of	IN
cord-336510-qzm9wgde	348	24	the	the	DT
cord-336510-qzm9wgde	348	25	IFN	IFN	NNP
cord-336510-qzm9wgde	348	26	-	-	HYPH
cord-336510-qzm9wgde	348	27	system	system	NN
cord-336510-qzm9wgde	348	28	[	[	-LRB-
cord-336510-qzm9wgde	348	29	283	283	CD
cord-336510-qzm9wgde	348	30	]	]	-RRB-
cord-336510-qzm9wgde	348	31	were	be	VBD
cord-336510-qzm9wgde	348	32	important	important	JJ
cord-336510-qzm9wgde	348	33	mediators	mediator	NNS
cord-336510-qzm9wgde	348	34	of	of	IN
cord-336510-qzm9wgde	348	35	innate	innate	JJ
cord-336510-qzm9wgde	348	36	resistance	resistance	NN
cord-336510-qzm9wgde	348	37	to	to	IN
cord-336510-qzm9wgde	348	38	HSV	HSV	NNP
cord-336510-qzm9wgde	348	39	.	.	.
cord-336510-qzm9wgde	349	1	The	the	DT
cord-336510-qzm9wgde	349	2	relative	relative	JJ
cord-336510-qzm9wgde	349	3	contribution	contribution	NN
cord-336510-qzm9wgde	349	4	of	of	IN
cord-336510-qzm9wgde	349	5	each	each	DT
cord-336510-qzm9wgde	349	6	of	of	IN
cord-336510-qzm9wgde	349	7	these	these	DT
cord-336510-qzm9wgde	349	8	players	player	NNS
cord-336510-qzm9wgde	349	9	in	in	IN
cord-336510-qzm9wgde	349	10	the	the	DT
cord-336510-qzm9wgde	349	11	early	early	JJ
cord-336510-qzm9wgde	349	12	defence	defence	NN
cord-336510-qzm9wgde	349	13	has	have	VBZ
cord-336510-qzm9wgde	349	14	been	be	VBN
cord-336510-qzm9wgde	349	15	much	much	RB
cord-336510-qzm9wgde	349	16	debated	debate	VBN
cord-336510-qzm9wgde	349	17	,	,	,
cord-336510-qzm9wgde	349	18	and	and	CC
cord-336510-qzm9wgde	349	19	as	as	IN
cord-336510-qzm9wgde	349	20	more	more	JJR
cord-336510-qzm9wgde	349	21	interactions	interaction	NNS
cord-336510-qzm9wgde	349	22	and	and	CC
cord-336510-qzm9wgde	349	23	molecular	molecular	JJ
cord-336510-qzm9wgde	349	24	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	349	25	are	be	VBP
cord-336510-qzm9wgde	349	26	now	now	RB
cord-336510-qzm9wgde	349	27	elucidated	elucidate	VBN
cord-336510-qzm9wgde	349	28	,	,	,
cord-336510-qzm9wgde	349	29	it	-PRON-	PRP
cord-336510-qzm9wgde	349	30	seems	seem	VBZ
cord-336510-qzm9wgde	349	31	clear	clear	JJ
cord-336510-qzm9wgde	349	32	that	that	IN
cord-336510-qzm9wgde	349	33	all	all	DT
cord-336510-qzm9wgde	349	34	of	of	IN
cord-336510-qzm9wgde	349	35	these	these	DT
cord-336510-qzm9wgde	349	36	players	player	NNS
cord-336510-qzm9wgde	349	37	each	each	DT
cord-336510-qzm9wgde	349	38	hold	hold	VBP
cord-336510-qzm9wgde	349	39	a	a	DT
cord-336510-qzm9wgde	349	40	crucial	crucial	JJ
cord-336510-qzm9wgde	349	41	position	position	NN
cord-336510-qzm9wgde	349	42	in	in	IN
cord-336510-qzm9wgde	349	43	an	an	DT
cord-336510-qzm9wgde	349	44	integrated	integrated	JJ
cord-336510-qzm9wgde	349	45	antiviral	antiviral	JJ
cord-336510-qzm9wgde	349	46	natural	natural	JJ
cord-336510-qzm9wgde	349	47	defence	defence	NN
cord-336510-qzm9wgde	349	48	system	system	NN
cord-336510-qzm9wgde	349	49	.	.	.
cord-336510-qzm9wgde	350	1	An	an	DT
cord-336510-qzm9wgde	350	2	important	important	JJ
cord-336510-qzm9wgde	350	3	model	model	NN
cord-336510-qzm9wgde	350	4	used	use	VBN
cord-336510-qzm9wgde	350	5	in	in	IN
cord-336510-qzm9wgde	350	6	the	the	DT
cord-336510-qzm9wgde	350	7	study	study	NN
cord-336510-qzm9wgde	350	8	of	of	IN
cord-336510-qzm9wgde	350	9	resistance	resistance	NN
cord-336510-qzm9wgde	350	10	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	350	11	in	in	IN
cord-336510-qzm9wgde	350	12	defence	defence	NN
cord-336510-qzm9wgde	350	13	against	against	IN
cord-336510-qzm9wgde	350	14	generalized	generalized	JJ
cord-336510-qzm9wgde	350	15	infection	infection	NN
cord-336510-qzm9wgde	350	16	with	with	IN
cord-336510-qzm9wgde	350	17	HSV	HSV	NNP
cord-336510-qzm9wgde	350	18	is	be	VBZ
cord-336510-qzm9wgde	350	19	a	a	DT
cord-336510-qzm9wgde	350	20	mouse	mouse	NN
cord-336510-qzm9wgde	350	21	model	model	NN
cord-336510-qzm9wgde	350	22	,	,	,
cord-336510-qzm9wgde	350	23	where	where	WRB
cord-336510-qzm9wgde	350	24	mice	mouse	NNS
cord-336510-qzm9wgde	350	25	infected	infect	VBD
cord-336510-qzm9wgde	350	26	intra	intra	JJ
cord-336510-qzm9wgde	350	27	-	-	JJ
cord-336510-qzm9wgde	350	28	peritoneally	peritoneally	JJ
cord-336510-qzm9wgde	350	29	or	or	CC
cord-336510-qzm9wgde	350	30	intra	intra	JJ
cord-336510-qzm9wgde	350	31	-	-	JJ
cord-336510-qzm9wgde	350	32	venously	venously	JJ
cord-336510-qzm9wgde	350	33	experience	experience	VB
cord-336510-qzm9wgde	350	34	a	a	DT
cord-336510-qzm9wgde	350	35	generalized	generalized	JJ
cord-336510-qzm9wgde	350	36	infection	infection	NN
cord-336510-qzm9wgde	350	37	with	with	IN
cord-336510-qzm9wgde	350	38	HSV	HSV	NNP
cord-336510-qzm9wgde	350	39	replication	replication	NN
cord-336510-qzm9wgde	350	40	in	in	IN
cord-336510-qzm9wgde	350	41	most	most	JJS
cord-336510-qzm9wgde	350	42	organs	organ	NNS
cord-336510-qzm9wgde	350	43	,	,	,
cord-336510-qzm9wgde	350	44	including	include	VBG
cord-336510-qzm9wgde	350	45	the	the	DT
cord-336510-qzm9wgde	350	46	liver	liver	NN
cord-336510-qzm9wgde	350	47	,	,	,
cord-336510-qzm9wgde	350	48	spleen	spleen	NNS
cord-336510-qzm9wgde	350	49	,	,	,
cord-336510-qzm9wgde	350	50	and	and	CC
cord-336510-qzm9wgde	350	51	eventually	eventually	RB
cord-336510-qzm9wgde	350	52	the	the	DT
cord-336510-qzm9wgde	350	53	brain	brain	NN
cord-336510-qzm9wgde	350	54	[	[	-LRB-
cord-336510-qzm9wgde	350	55	284	284	CD
cord-336510-qzm9wgde	350	56	]	]	-RRB-
cord-336510-qzm9wgde	350	57	.	.	.
cord-336510-qzm9wgde	351	1	The	the	DT
cord-336510-qzm9wgde	351	2	dissemination	dissemination	NN
cord-336510-qzm9wgde	351	3	of	of	IN
cord-336510-qzm9wgde	351	4	infection	infection	NN
cord-336510-qzm9wgde	351	5	to	to	IN
cord-336510-qzm9wgde	351	6	the	the	DT
cord-336510-qzm9wgde	351	7	brain	brain	NN
cord-336510-qzm9wgde	351	8	and	and	CC
cord-336510-qzm9wgde	351	9	the	the	DT
cord-336510-qzm9wgde	351	10	severity	severity	NN
cord-336510-qzm9wgde	351	11	of	of	IN
cord-336510-qzm9wgde	351	12	infection	infection	NN
cord-336510-qzm9wgde	351	13	of	of	IN
cord-336510-qzm9wgde	351	14	the	the	DT
cord-336510-qzm9wgde	351	15	peripheral	peripheral	JJ
cord-336510-qzm9wgde	351	16	organs	organ	NNS
cord-336510-qzm9wgde	351	17	depend	depend	VBP
cord-336510-qzm9wgde	351	18	in	in	IN
cord-336510-qzm9wgde	351	19	part	part	NN
cord-336510-qzm9wgde	351	20	on	on	IN
cord-336510-qzm9wgde	351	21	the	the	DT
cord-336510-qzm9wgde	351	22	age	age	NN
cord-336510-qzm9wgde	351	23	of	of	IN
cord-336510-qzm9wgde	351	24	the	the	DT
cord-336510-qzm9wgde	351	25	mice	mouse	NNS
cord-336510-qzm9wgde	351	26	,	,	,
cord-336510-qzm9wgde	351	27	as	as	IN
cord-336510-qzm9wgde	351	28	is	be	VBZ
cord-336510-qzm9wgde	351	29	the	the	DT
cord-336510-qzm9wgde	351	30	case	case	NN
cord-336510-qzm9wgde	351	31	in	in	IN
cord-336510-qzm9wgde	351	32	humans	human	NNS
cord-336510-qzm9wgde	351	33	,	,	,
cord-336510-qzm9wgde	351	34	where	where	WRB
cord-336510-qzm9wgde	351	35	neonates	neonate	NNS
cord-336510-qzm9wgde	351	36	have	have	VBP
cord-336510-qzm9wgde	351	37	difficulties	difficulty	NNS
cord-336510-qzm9wgde	351	38	in	in	IN
cord-336510-qzm9wgde	351	39	controlling	control	VBG
cord-336510-qzm9wgde	351	40	a	a	DT
cord-336510-qzm9wgde	351	41	HSV	HSV	NNP
cord-336510-qzm9wgde	351	42	infection	infection	NN
cord-336510-qzm9wgde	351	43	[	[	-LRB-
cord-336510-qzm9wgde	351	44	281	281	CD
cord-336510-qzm9wgde	351	45	,	,	,
cord-336510-qzm9wgde	351	46	[	[	-LRB-
cord-336510-qzm9wgde	351	47	285	285	CD
cord-336510-qzm9wgde	351	48	]	]	-RRB-
cord-336510-qzm9wgde	351	49	[	[	-LRB-
cord-336510-qzm9wgde	351	50	286	286	CD
cord-336510-qzm9wgde	351	51	]	]	-RRB-
cord-336510-qzm9wgde	351	52	[	[	-LRB-
cord-336510-qzm9wgde	351	53	287	287	CD
cord-336510-qzm9wgde	351	54	]	]	-RRB-
cord-336510-qzm9wgde	351	55	.	.	.
cord-336510-qzm9wgde	352	1	The	the	DT
cord-336510-qzm9wgde	352	2	course	course	NN
cord-336510-qzm9wgde	352	3	of	of	IN
cord-336510-qzm9wgde	352	4	infection	infection	NN
cord-336510-qzm9wgde	352	5	in	in	IN
cord-336510-qzm9wgde	352	6	mice	mouse	NNS
cord-336510-qzm9wgde	352	7	also	also	RB
cord-336510-qzm9wgde	352	8	depends	depend	VBZ
cord-336510-qzm9wgde	352	9	on	on	IN
cord-336510-qzm9wgde	352	10	the	the	DT
cord-336510-qzm9wgde	352	11	type	type	NN
cord-336510-qzm9wgde	352	12	of	of	IN
cord-336510-qzm9wgde	352	13	HSV	HSV	NNP
cord-336510-qzm9wgde	352	14	in	in	IN
cord-336510-qzm9wgde	352	15	question	question	NN
cord-336510-qzm9wgde	352	16	.	.	.
cord-336510-qzm9wgde	353	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	353	2	,	,	,
cord-336510-qzm9wgde	353	3	in	in	IN
cord-336510-qzm9wgde	353	4	1975	1975	CD
cord-336510-qzm9wgde	353	5	Lopez	Lopez	NNP
cord-336510-qzm9wgde	353	6	described	describe	VBD
cord-336510-qzm9wgde	353	7	a	a	DT
cord-336510-qzm9wgde	353	8	differential	differential	JJ
cord-336510-qzm9wgde	353	9	susceptibility	susceptibility	NN
cord-336510-qzm9wgde	353	10	of	of	IN
cord-336510-qzm9wgde	353	11	inbred	inbred	JJ
cord-336510-qzm9wgde	353	12	mice	mouse	NNS
cord-336510-qzm9wgde	353	13	to	to	IN
cord-336510-qzm9wgde	353	14	generalized	generalize	VBN
cord-336510-qzm9wgde	353	15	infection	infection	NN
cord-336510-qzm9wgde	353	16	with	with	IN
cord-336510-qzm9wgde	353	17	HSV	HSV	NNP
cord-336510-qzm9wgde	353	18	,	,	,
cord-336510-qzm9wgde	353	19	and	and	CC
cord-336510-qzm9wgde	353	20	this	this	DT
cord-336510-qzm9wgde	353	21	genetic	genetic	JJ
cord-336510-qzm9wgde	353	22	difference	difference	NN
cord-336510-qzm9wgde	353	23	in	in	IN
cord-336510-qzm9wgde	353	24	sensitivity	sensitivity	NN
cord-336510-qzm9wgde	353	25	has	have	VBZ
cord-336510-qzm9wgde	353	26	since	since	IN
cord-336510-qzm9wgde	353	27	been	be	VBN
cord-336510-qzm9wgde	353	28	used	use	VBN
cord-336510-qzm9wgde	353	29	for	for	IN
cord-336510-qzm9wgde	353	30	analysis	analysis	NN
cord-336510-qzm9wgde	353	31	of	of	IN
cord-336510-qzm9wgde	353	32	resistance	resistance	NN
cord-336510-qzm9wgde	353	33	factors	factor	NNS
cord-336510-qzm9wgde	353	34	of	of	IN
cord-336510-qzm9wgde	353	35	importance	importance	NN
cord-336510-qzm9wgde	353	36	for	for	IN
cord-336510-qzm9wgde	353	37	the	the	DT
cord-336510-qzm9wgde	353	38	anti	anti	JJ
cord-336510-qzm9wgde	353	39	-	-	JJ
cord-336510-qzm9wgde	353	40	herpetic	herpetic	JJ
cord-336510-qzm9wgde	353	41	defence	defence	NN
cord-336510-qzm9wgde	353	42	[	[	-LRB-
cord-336510-qzm9wgde	353	43	288	288	CD
cord-336510-qzm9wgde	353	44	]	]	-RRB-
cord-336510-qzm9wgde	353	45	.	.	.
cord-336510-qzm9wgde	354	1	In	in	IN
cord-336510-qzm9wgde	354	2	generalized	generalized	JJ
cord-336510-qzm9wgde	354	3	infections	infection	NNS
cord-336510-qzm9wgde	354	4	,	,	,
cord-336510-qzm9wgde	354	5	the	the	DT
cord-336510-qzm9wgde	354	6	genetics	genetic	NNS
cord-336510-qzm9wgde	354	7	of	of	IN
cord-336510-qzm9wgde	354	8	the	the	DT
cord-336510-qzm9wgde	354	9	relative	relative	JJ
cord-336510-qzm9wgde	354	10	resistance	resistance	NN
cord-336510-qzm9wgde	354	11	to	to	IN
cord-336510-qzm9wgde	354	12	HSV-2	HSV-2	NNP
cord-336510-qzm9wgde	354	13	was	be	VBD
cord-336510-qzm9wgde	354	14	shown	show	VBN
cord-336510-qzm9wgde	354	15	to	to	TO
cord-336510-qzm9wgde	354	16	segregate	segregate	VB
cord-336510-qzm9wgde	354	17	with	with	IN
cord-336510-qzm9wgde	354	18	the	the	DT
cord-336510-qzm9wgde	354	19	X	x	NN
cord-336510-qzm9wgde	354	20	-	-	NN
cord-336510-qzm9wgde	354	21	chromosome	chromosome	NN
cord-336510-qzm9wgde	354	22	[	[	-LRB-
cord-336510-qzm9wgde	354	23	289	289	CD
cord-336510-qzm9wgde	354	24	]	]	-RRB-
cord-336510-qzm9wgde	354	25	.	.	.
cord-336510-qzm9wgde	355	1	This	this	DT
cord-336510-qzm9wgde	355	2	pattern	pattern	NN
cord-336510-qzm9wgde	355	3	of	of	IN
cord-336510-qzm9wgde	355	4	resistance	resistance	NN
cord-336510-qzm9wgde	355	5	to	to	IN
cord-336510-qzm9wgde	355	6	the	the	DT
cord-336510-qzm9wgde	355	7	generalized	generalized	JJ
cord-336510-qzm9wgde	355	8	infection	infection	NN
cord-336510-qzm9wgde	355	9	was	be	VBD
cord-336510-qzm9wgde	355	10	for	for	IN
cord-336510-qzm9wgde	355	11	both	both	CC
cord-336510-qzm9wgde	355	12	HSV-1	HSV-1	NNS
cord-336510-qzm9wgde	355	13	and	and	CC
cord-336510-qzm9wgde	355	14	-2	-2	NNP
cord-336510-qzm9wgde	355	15	attributed	attribute	VBN
cord-336510-qzm9wgde	355	16	to	to	IN
cord-336510-qzm9wgde	355	17	a	a	DT
cord-336510-qzm9wgde	355	18	genetically	genetically	RB
cord-336510-qzm9wgde	355	19	determined	determine	VBN
cord-336510-qzm9wgde	355	20	difference	difference	NN
cord-336510-qzm9wgde	355	21	in	in	IN
cord-336510-qzm9wgde	355	22	the	the	DT
cord-336510-qzm9wgde	355	23	capacity	capacity	NN
cord-336510-qzm9wgde	355	24	for	for	IN
cord-336510-qzm9wgde	355	25	IFN	IFN	NNP
cord-336510-qzm9wgde	355	26	-	-	HYPH
cord-336510-qzm9wgde	355	27	α	α	NNP
cord-336510-qzm9wgde	355	28	/	/	SYM
cord-336510-qzm9wgde	355	29	β	β	NN
cord-336510-qzm9wgde	355	30	production	production	NN
cord-336510-qzm9wgde	355	31	[	[	-LRB-
cord-336510-qzm9wgde	355	32	179	179	CD
cord-336510-qzm9wgde	355	33	,	,	,
cord-336510-qzm9wgde	355	34	290	290	CD
cord-336510-qzm9wgde	355	35	,	,	,
cord-336510-qzm9wgde	355	36	291	291	CD
cord-336510-qzm9wgde	355	37	]	]	-RRB-
cord-336510-qzm9wgde	355	38	,	,	,
cord-336510-qzm9wgde	355	39	and	and	CC
cord-336510-qzm9wgde	355	40	it	-PRON-	PRP
cord-336510-qzm9wgde	355	41	was	be	VBD
cord-336510-qzm9wgde	355	42	shown	show	VBN
cord-336510-qzm9wgde	355	43	that	that	IN
cord-336510-qzm9wgde	355	44	the	the	DT
cord-336510-qzm9wgde	355	45	X	x	NN
cord-336510-qzm9wgde	355	46	-	-	HYPH
cord-336510-qzm9wgde	355	47	linked	link	VBN
cord-336510-qzm9wgde	355	48	pattern	pattern	NN
cord-336510-qzm9wgde	355	49	of	of	IN
cord-336510-qzm9wgde	355	50	resistance	resistance	NN
cord-336510-qzm9wgde	355	51	segregated	segregate	VBN
cord-336510-qzm9wgde	355	52	with	with	IN
cord-336510-qzm9wgde	355	53	the	the	DT
cord-336510-qzm9wgde	355	54	HSV-2-induced	hsv-2-induce	VBN
cord-336510-qzm9wgde	355	55	production	production	NN
cord-336510-qzm9wgde	355	56	of	of	IN
cord-336510-qzm9wgde	355	57	IFN	IFN	NNP
cord-336510-qzm9wgde	355	58	-	-	HYPH
cord-336510-qzm9wgde	355	59	α	α	NNP
cord-336510-qzm9wgde	355	60	/	/	SYM
cord-336510-qzm9wgde	355	61	β	β	NN
cord-336510-qzm9wgde	355	62	in	in	IN
cord-336510-qzm9wgde	355	63	macrophages	macrophage	NNS
cord-336510-qzm9wgde	355	64	during	during	IN
cord-336510-qzm9wgde	355	65	the	the	DT
cord-336510-qzm9wgde	355	66	first	first	JJ
cord-336510-qzm9wgde	355	67	hours	hour	NNS
cord-336510-qzm9wgde	355	68	of	of	IN
cord-336510-qzm9wgde	355	69	infection	infection	NN
cord-336510-qzm9wgde	355	70	[	[	-LRB-
cord-336510-qzm9wgde	355	71	168	168	CD
cord-336510-qzm9wgde	355	72	]	]	-RRB-
cord-336510-qzm9wgde	355	73	.	.	.
cord-336510-qzm9wgde	356	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	356	2	,	,	,
cord-336510-qzm9wgde	356	3	macrophages	macrophage	NNS
cord-336510-qzm9wgde	356	4	from	from	IN
cord-336510-qzm9wgde	356	5	female	female	JJ
cord-336510-qzm9wgde	356	6	mice	mouse	NNS
cord-336510-qzm9wgde	356	7	respond	respond	VBP
cord-336510-qzm9wgde	356	8	to	to	IN
cord-336510-qzm9wgde	356	9	HSV	HSV	NNP
cord-336510-qzm9wgde	356	10	with	with	IN
cord-336510-qzm9wgde	356	11	higher	high	JJR
cord-336510-qzm9wgde	356	12	IFN	IFN	NNP
cord-336510-qzm9wgde	356	13	-	-	HYPH
cord-336510-qzm9wgde	356	14	α	α	NNP
cord-336510-qzm9wgde	356	15	/	/	SYM
cord-336510-qzm9wgde	356	16	β	β	NN
cord-336510-qzm9wgde	356	17	production	production	NN
cord-336510-qzm9wgde	356	18	than	than	IN
cord-336510-qzm9wgde	356	19	macrophages	macrophage	NNS
cord-336510-qzm9wgde	356	20	from	from	IN
cord-336510-qzm9wgde	356	21	male	male	JJ
cord-336510-qzm9wgde	356	22	mice	mouse	NNS
cord-336510-qzm9wgde	356	23	[	[	-LRB-
cord-336510-qzm9wgde	356	24	168	168	CD
cord-336510-qzm9wgde	356	25	]	]	-RRB-
cord-336510-qzm9wgde	356	26	.	.	.
cord-336510-qzm9wgde	357	1	This	this	DT
cord-336510-qzm9wgde	357	2	observation	observation	NN
cord-336510-qzm9wgde	357	3	is	be	VBZ
cord-336510-qzm9wgde	357	4	in	in	IN
cord-336510-qzm9wgde	357	5	line	line	NN
cord-336510-qzm9wgde	357	6	with	with	IN
cord-336510-qzm9wgde	357	7	female	female	JJ
cord-336510-qzm9wgde	357	8	mice	mouse	NNS
cord-336510-qzm9wgde	357	9	being	be	VBG
cord-336510-qzm9wgde	357	10	more	more	RBR
cord-336510-qzm9wgde	357	11	resistant	resistant	JJ
cord-336510-qzm9wgde	357	12	to	to	IN
cord-336510-qzm9wgde	357	13	HSV	HSV	NNP
cord-336510-qzm9wgde	357	14	infection	infection	NN
cord-336510-qzm9wgde	357	15	in	in	IN
cord-336510-qzm9wgde	357	16	vivo	vivo	NNP
cord-336510-qzm9wgde	357	17	[	[	-LRB-
cord-336510-qzm9wgde	357	18	291	291	CD
cord-336510-qzm9wgde	357	19	]	]	-RRB-
cord-336510-qzm9wgde	357	20	.	.	.
cord-336510-qzm9wgde	358	1	Early	early	JJ
cord-336510-qzm9wgde	358	2	production	production	NN
cord-336510-qzm9wgde	358	3	of	of	IN
cord-336510-qzm9wgde	358	4	IFN	IFN	NNP
cord-336510-qzm9wgde	358	5	-	-	HYPH
cord-336510-qzm9wgde	358	6	α	α	NNP
cord-336510-qzm9wgde	358	7	/	/	SYM
cord-336510-qzm9wgde	358	8	β	β	NN
cord-336510-qzm9wgde	358	9	has	have	VBZ
cord-336510-qzm9wgde	358	10	been	be	VBN
cord-336510-qzm9wgde	358	11	correlated	correlate	VBN
cord-336510-qzm9wgde	358	12	to	to	IN
cord-336510-qzm9wgde	358	13	resistance	resistance	NN
cord-336510-qzm9wgde	358	14	of	of	IN
cord-336510-qzm9wgde	358	15	HSV	HSV	NNP
cord-336510-qzm9wgde	358	16	infections	infection	NNS
cord-336510-qzm9wgde	358	17	in	in	IN
cord-336510-qzm9wgde	358	18	several	several	JJ
cord-336510-qzm9wgde	358	19	other	other	JJ
cord-336510-qzm9wgde	358	20	studies	study	NNS
cord-336510-qzm9wgde	358	21	.	.	.
cord-336510-qzm9wgde	359	1	Treatment	treatment	NN
cord-336510-qzm9wgde	359	2	of	of	IN
cord-336510-qzm9wgde	359	3	mice	mouse	NNS
cord-336510-qzm9wgde	359	4	with	with	IN
cord-336510-qzm9wgde	359	5	antibodies	antibody	NNS
cord-336510-qzm9wgde	359	6	to	to	IN
cord-336510-qzm9wgde	359	7	IFN	IFN	NNP
cord-336510-qzm9wgde	359	8	-	-	HYPH
cord-336510-qzm9wgde	359	9	α	α	NNP
cord-336510-qzm9wgde	359	10	/	/	SYM
cord-336510-qzm9wgde	359	11	β	β	NN
cord-336510-qzm9wgde	359	12	increases	increase	VBZ
cord-336510-qzm9wgde	359	13	and	and	CC
cord-336510-qzm9wgde	359	14	accelerates	accelerate	VBZ
cord-336510-qzm9wgde	359	15	mortality	mortality	NN
cord-336510-qzm9wgde	359	16	of	of	IN
cord-336510-qzm9wgde	359	17	a	a	DT
cord-336510-qzm9wgde	359	18	generalized	generalized	JJ
cord-336510-qzm9wgde	359	19	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	359	20	infection	infection	NN
cord-336510-qzm9wgde	359	21	and	and	CC
cord-336510-qzm9wgde	359	22	with	with	IN
cord-336510-qzm9wgde	359	23	higher	high	JJR
cord-336510-qzm9wgde	359	24	doses	dose	NNS
cord-336510-qzm9wgde	359	25	of	of	IN
cord-336510-qzm9wgde	359	26	virus	virus	NN
cord-336510-qzm9wgde	359	27	,	,	,
cord-336510-qzm9wgde	359	28	mice	mouse	NNS
cord-336510-qzm9wgde	359	29	are	be	VBP
cord-336510-qzm9wgde	359	30	dying	die	VBG
cord-336510-qzm9wgde	359	31	already	already	RB
cord-336510-qzm9wgde	359	32	after	after	IN
cord-336510-qzm9wgde	359	33	three	three	CD
cord-336510-qzm9wgde	359	34	to	to	TO
cord-336510-qzm9wgde	359	35	four	four	CD
cord-336510-qzm9wgde	359	36	days	day	NNS
cord-336510-qzm9wgde	359	37	,	,	,
cord-336510-qzm9wgde	359	38	a	a	DT
cord-336510-qzm9wgde	359	39	period	period	NN
cord-336510-qzm9wgde	359	40	where	where	WRB
cord-336510-qzm9wgde	359	41	antigen	antigen	NN
cord-336510-qzm9wgde	359	42	-	-	HYPH
cord-336510-qzm9wgde	359	43	specific	specific	JJ
cord-336510-qzm9wgde	359	44	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	359	45	are	be	VBP
cord-336510-qzm9wgde	359	46	still	still	RB
cord-336510-qzm9wgde	359	47	in	in	IN
cord-336510-qzm9wgde	359	48	the	the	DT
cord-336510-qzm9wgde	359	49	induction	induction	NN
cord-336510-qzm9wgde	359	50	and	and	CC
cord-336510-qzm9wgde	359	51	proliferation	proliferation	NN
cord-336510-qzm9wgde	359	52	phase	phase	NN
cord-336510-qzm9wgde	359	53	[	[	-LRB-
cord-336510-qzm9wgde	359	54	292	292	CD
cord-336510-qzm9wgde	359	55	]	]	-RRB-
cord-336510-qzm9wgde	359	56	.	.	.
cord-336510-qzm9wgde	360	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	360	2	,	,	,
cord-336510-qzm9wgde	360	3	mice	mouse	NNS
cord-336510-qzm9wgde	360	4	treated	treat	VBN
cord-336510-qzm9wgde	360	5	with	with	IN
cord-336510-qzm9wgde	360	6	mercuric	mercuric	NN
cord-336510-qzm9wgde	360	7	chloride	chloride	NN
cord-336510-qzm9wgde	360	8	showed	show	VBD
cord-336510-qzm9wgde	360	9	higher	high	JJR
cord-336510-qzm9wgde	360	10	titres	titre	NNS
cord-336510-qzm9wgde	360	11	of	of	IN
cord-336510-qzm9wgde	360	12	HSV-2	HSV-2	NNPS
cord-336510-qzm9wgde	360	13	in	in	IN
cord-336510-qzm9wgde	360	14	the	the	DT
cord-336510-qzm9wgde	360	15	first	first	JJ
cord-336510-qzm9wgde	360	16	days	day	NNS
cord-336510-qzm9wgde	360	17	of	of	IN
cord-336510-qzm9wgde	360	18	infection	infection	NN
cord-336510-qzm9wgde	360	19	,	,	,
cord-336510-qzm9wgde	360	20	an	an	DT
cord-336510-qzm9wgde	360	21	effect	effect	NN
cord-336510-qzm9wgde	360	22	which	which	WDT
cord-336510-qzm9wgde	360	23	could	could	MD
cord-336510-qzm9wgde	360	24	be	be	VB
cord-336510-qzm9wgde	360	25	correlated	correlate	VBN
cord-336510-qzm9wgde	360	26	to	to	IN
cord-336510-qzm9wgde	360	27	impaired	impaired	JJ
cord-336510-qzm9wgde	360	28	production	production	NN
cord-336510-qzm9wgde	360	29	of	of	IN
cord-336510-qzm9wgde	360	30	IFN	IFN	NNP
cord-336510-qzm9wgde	360	31	-	-	HYPH
cord-336510-qzm9wgde	360	32	α	α	NNP
cord-336510-qzm9wgde	360	33	/	/	SYM
cord-336510-qzm9wgde	360	34	β	β	NN
cord-336510-qzm9wgde	360	35	[	[	-LRB-
cord-336510-qzm9wgde	360	36	293	293	CD
cord-336510-qzm9wgde	360	37	,	,	,
cord-336510-qzm9wgde	360	38	294	294	CD
cord-336510-qzm9wgde	360	39	]	]	-RRB-
cord-336510-qzm9wgde	360	40	.	.	.
cord-336510-qzm9wgde	361	1	In	in	IN
cord-336510-qzm9wgde	361	2	studies	study	NNS
cord-336510-qzm9wgde	361	3	on	on	IN
cord-336510-qzm9wgde	361	4	peripheral	peripheral	JJ
cord-336510-qzm9wgde	361	5	HSV	HSV	NNP
cord-336510-qzm9wgde	361	6	infections	infection	NNS
cord-336510-qzm9wgde	361	7	,	,	,
cord-336510-qzm9wgde	361	8	such	such	JJ
cord-336510-qzm9wgde	361	9	as	as	IN
cord-336510-qzm9wgde	361	10	cutaneous	cutaneous	JJ
cord-336510-qzm9wgde	361	11	or	or	CC
cord-336510-qzm9wgde	361	12	corneal	corneal	JJ
cord-336510-qzm9wgde	361	13	infections	infection	NNS
cord-336510-qzm9wgde	361	14	,	,	,
cord-336510-qzm9wgde	361	15	IFN	IFN	NNP
cord-336510-qzm9wgde	361	16	-	-	HYPH
cord-336510-qzm9wgde	361	17	α	α	NNP
cord-336510-qzm9wgde	361	18	/	/	SYM
cord-336510-qzm9wgde	361	19	β	β	NN
cord-336510-qzm9wgde	361	20	has	have	VBZ
cord-336510-qzm9wgde	361	21	been	be	VBN
cord-336510-qzm9wgde	361	22	shown	show	VBN
cord-336510-qzm9wgde	361	23	to	to	TO
cord-336510-qzm9wgde	361	24	be	be	VB
cord-336510-qzm9wgde	361	25	produced	produce	VBN
cord-336510-qzm9wgde	361	26	locally	locally	RB
cord-336510-qzm9wgde	361	27	and	and	CC
cord-336510-qzm9wgde	361	28	to	to	TO
cord-336510-qzm9wgde	361	29	restrict	restrict	VB
cord-336510-qzm9wgde	361	30	the	the	DT
cord-336510-qzm9wgde	361	31	local	local	JJ
cord-336510-qzm9wgde	361	32	replication	replication	NN
cord-336510-qzm9wgde	361	33	of	of	IN
cord-336510-qzm9wgde	361	34	HSV	HSV	NNP
cord-336510-qzm9wgde	361	35	and	and	CC
cord-336510-qzm9wgde	361	36	infection	infection	NN
cord-336510-qzm9wgde	361	37	of	of	IN
cord-336510-qzm9wgde	361	38	nervous	nervous	JJ
cord-336510-qzm9wgde	361	39	ganglia	ganglion	NNS
cord-336510-qzm9wgde	361	40	cells	cell	NNS
cord-336510-qzm9wgde	361	41	of	of	IN
cord-336510-qzm9wgde	361	42	the	the	DT
cord-336510-qzm9wgde	361	43	area	area	NN
cord-336510-qzm9wgde	361	44	,	,	,
cord-336510-qzm9wgde	361	45	an	an	DT
cord-336510-qzm9wgde	361	46	effect	effect	NN
cord-336510-qzm9wgde	361	47	which	which	WDT
cord-336510-qzm9wgde	361	48	has	have	VBZ
cord-336510-qzm9wgde	361	49	also	also	RB
cord-336510-qzm9wgde	361	50	been	be	VBN
cord-336510-qzm9wgde	361	51	correlated	correlate	VBN
cord-336510-qzm9wgde	361	52	to	to	IN
cord-336510-qzm9wgde	361	53	the	the	DT
cord-336510-qzm9wgde	361	54	genetic	genetic	JJ
cord-336510-qzm9wgde	361	55	constitution	constitution	NN
cord-336510-qzm9wgde	361	56	of	of	IN
cord-336510-qzm9wgde	361	57	the	the	DT
cord-336510-qzm9wgde	361	58	host	host	NN
cord-336510-qzm9wgde	361	59	[	[	-LRB-
cord-336510-qzm9wgde	361	60	295	295	CD
cord-336510-qzm9wgde	361	61	]	]	-RRB-
cord-336510-qzm9wgde	361	62	[	[	-LRB-
cord-336510-qzm9wgde	361	63	296	296	CD
cord-336510-qzm9wgde	361	64	]	]	-RRB-
cord-336510-qzm9wgde	361	65	[	[	-LRB-
cord-336510-qzm9wgde	361	66	297	297	CD
cord-336510-qzm9wgde	361	67	]	]	-RRB-
cord-336510-qzm9wgde	361	68	[	[	-LRB-
cord-336510-qzm9wgde	361	69	298	298	CD
cord-336510-qzm9wgde	361	70	]	]	-RRB-
cord-336510-qzm9wgde	361	71	.	.	.
cord-336510-qzm9wgde	362	1	The	the	DT
cord-336510-qzm9wgde	362	2	genetic	genetic	JJ
cord-336510-qzm9wgde	362	3	background	background	NN
cord-336510-qzm9wgde	362	4	for	for	IN
cord-336510-qzm9wgde	362	5	the	the	DT
cord-336510-qzm9wgde	362	6	X	x	NN
cord-336510-qzm9wgde	362	7	-	-	HYPH
cord-336510-qzm9wgde	362	8	linked	link	VBN
cord-336510-qzm9wgde	362	9	trait	trait	NN
cord-336510-qzm9wgde	362	10	of	of	IN
cord-336510-qzm9wgde	362	11	HSV	HSV	NNP
cord-336510-qzm9wgde	362	12	resistance	resistance	NN
cord-336510-qzm9wgde	362	13	and	and	CC
cord-336510-qzm9wgde	362	14	IFN	IFN	NNP
cord-336510-qzm9wgde	362	15	-	-	HYPH
cord-336510-qzm9wgde	362	16	α	α	NNP
cord-336510-qzm9wgde	362	17	/	/	SYM
cord-336510-qzm9wgde	362	18	β	β	NN
cord-336510-qzm9wgde	362	19	production	production	NN
cord-336510-qzm9wgde	362	20	of	of	IN
cord-336510-qzm9wgde	362	21	macrophages	macrophage	NNS
cord-336510-qzm9wgde	362	22	remains	remain	VBZ
cord-336510-qzm9wgde	362	23	unravelled	unravelled	JJ
cord-336510-qzm9wgde	362	24	.	.	.
cord-336510-qzm9wgde	363	1	Induction	induction	NN
cord-336510-qzm9wgde	363	2	of	of	IN
cord-336510-qzm9wgde	363	3	IFN	IFN	NNP
cord-336510-qzm9wgde	363	4	-	-	HYPH
cord-336510-qzm9wgde	363	5	α	α	NNP
cord-336510-qzm9wgde	363	6	/	/	SYM
cord-336510-qzm9wgde	363	7	β	β	NN
cord-336510-qzm9wgde	363	8	upon	upon	IN
cord-336510-qzm9wgde	363	9	HSV	HSV	NNP
cord-336510-qzm9wgde	363	10	infection	infection	NN
cord-336510-qzm9wgde	363	11	seems	seem	VBZ
cord-336510-qzm9wgde	363	12	to	to	TO
cord-336510-qzm9wgde	363	13	be	be	VB
cord-336510-qzm9wgde	363	14	governed	govern	VBN
cord-336510-qzm9wgde	363	15	by	by	IN
cord-336510-qzm9wgde	363	16	different	different	JJ
cord-336510-qzm9wgde	363	17	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	363	18	in	in	IN
cord-336510-qzm9wgde	363	19	different	different	JJ
cord-336510-qzm9wgde	363	20	cells	cell	NNS
cord-336510-qzm9wgde	363	21	[	[	-LRB-
cord-336510-qzm9wgde	363	22	299	299	CD
cord-336510-qzm9wgde	363	23	]	]	-RRB-
cord-336510-qzm9wgde	363	24	.	.	.
cord-336510-qzm9wgde	364	1	IFN	IFN	NNP
cord-336510-qzm9wgde	364	2	-	-	HYPH
cord-336510-qzm9wgde	364	3	α	α	NNP
cord-336510-qzm9wgde	364	4	/	/	SYM
cord-336510-qzm9wgde	364	5	β	β	NN
cord-336510-qzm9wgde	364	6	can	can	MD
cord-336510-qzm9wgde	364	7	be	be	VB
cord-336510-qzm9wgde	364	8	induced	induce	VBN
cord-336510-qzm9wgde	364	9	early	early	RB
cord-336510-qzm9wgde	364	10	by	by	IN
cord-336510-qzm9wgde	364	11	both	both	CC
cord-336510-qzm9wgde	364	12	infectious	infectious	JJ
cord-336510-qzm9wgde	364	13	and	and	CC
cord-336510-qzm9wgde	364	14	UV	uv	NN
cord-336510-qzm9wgde	364	15	-	-	HYPH
cord-336510-qzm9wgde	364	16	inactivated	inactivate	VBN
cord-336510-qzm9wgde	364	17	HSV	HSV	NNP
cord-336510-qzm9wgde	364	18	in	in	IN
cord-336510-qzm9wgde	364	19	various	various	JJ
cord-336510-qzm9wgde	364	20	cells	cell	NNS
cord-336510-qzm9wgde	364	21	,	,	,
cord-336510-qzm9wgde	364	22	with	with	IN
cord-336510-qzm9wgde	364	23	the	the	DT
cord-336510-qzm9wgde	364	24	infectious	infectious	JJ
cord-336510-qzm9wgde	364	25	virus	virus	NN
cord-336510-qzm9wgde	364	26	being	be	VBG
cord-336510-qzm9wgde	364	27	the	the	DT
cord-336510-qzm9wgde	364	28	more	more	RBR
cord-336510-qzm9wgde	364	29	potent	potent	JJ
cord-336510-qzm9wgde	364	30	inducer	inducer	NN
cord-336510-qzm9wgde	364	31	in	in	IN
cord-336510-qzm9wgde	364	32	mouse	mouse	NN
cord-336510-qzm9wgde	364	33	peritoneal	peritoneal	JJ
cord-336510-qzm9wgde	364	34	macrophages	macrophage	NNS
cord-336510-qzm9wgde	364	35	,	,	,
cord-336510-qzm9wgde	364	36	whereas	whereas	IN
cord-336510-qzm9wgde	364	37	the	the	DT
cord-336510-qzm9wgde	364	38	UV	uv	NN
cord-336510-qzm9wgde	364	39	-	-	HYPH
cord-336510-qzm9wgde	364	40	inactivated	inactivate	VBN
cord-336510-qzm9wgde	364	41	virus	virus	NN
cord-336510-qzm9wgde	364	42	showed	show	VBD
cord-336510-qzm9wgde	364	43	most	most	JJS
cord-336510-qzm9wgde	364	44	potency	potency	JJ
cord-336510-qzm9wgde	364	45	in	in	IN
cord-336510-qzm9wgde	364	46	human	human	JJ
cord-336510-qzm9wgde	364	47	peripheral	peripheral	JJ
cord-336510-qzm9wgde	364	48	blood	blood	NN
cord-336510-qzm9wgde	364	49	mononuclear	mononuclear	NN
cord-336510-qzm9wgde	364	50	cells	cell	NNS
cord-336510-qzm9wgde	364	51	(	(	-LRB-
cord-336510-qzm9wgde	364	52	PBMC	PBMC	NNP
cord-336510-qzm9wgde	364	53	)	)	-RRB-
cord-336510-qzm9wgde	364	54	[	[	-LRB-
cord-336510-qzm9wgde	364	55	168	168	CD
cord-336510-qzm9wgde	364	56	,	,	,
cord-336510-qzm9wgde	364	57	[	[	-LRB-
cord-336510-qzm9wgde	364	58	299	299	CD
cord-336510-qzm9wgde	364	59	]	]	-RRB-
cord-336510-qzm9wgde	364	60	[	[	-LRB-
cord-336510-qzm9wgde	364	61	300	300	CD
cord-336510-qzm9wgde	364	62	]	]	-RRB-
cord-336510-qzm9wgde	364	63	[	[	-LRB-
cord-336510-qzm9wgde	364	64	301	301	CD
cord-336510-qzm9wgde	364	65	]	]	-RRB-
cord-336510-qzm9wgde	364	66	[	[	-LRB-
cord-336510-qzm9wgde	364	67	302	302	CD
cord-336510-qzm9wgde	364	68	]	]	-RRB-
cord-336510-qzm9wgde	364	69	.	.	.
cord-336510-qzm9wgde	365	1	Production	production	NN
cord-336510-qzm9wgde	365	2	of	of	IN
cord-336510-qzm9wgde	365	3	IFN	IFN	NNP
cord-336510-qzm9wgde	365	4	-	-	HYPH
cord-336510-qzm9wgde	365	5	α	α	NNP
cord-336510-qzm9wgde	365	6	/	/	SYM
cord-336510-qzm9wgde	365	7	β	β	NN
cord-336510-qzm9wgde	365	8	was	be	VBD
cord-336510-qzm9wgde	365	9	induced	induce	VBN
cord-336510-qzm9wgde	365	10	by	by	IN
cord-336510-qzm9wgde	365	11	gD	gd	DT
cord-336510-qzm9wgde	365	12	of	of	IN
cord-336510-qzm9wgde	365	13	HSV-1	HSV-1	NNP
cord-336510-qzm9wgde	365	14	in	in	IN
cord-336510-qzm9wgde	365	15	PBMC	PBMC	NNP
cord-336510-qzm9wgde	365	16	,	,	,
cord-336510-qzm9wgde	365	17	but	but	CC
cord-336510-qzm9wgde	365	18	not	not	RB
cord-336510-qzm9wgde	365	19	in	in	IN
cord-336510-qzm9wgde	365	20	murine	murine	JJ
cord-336510-qzm9wgde	365	21	macrophages	macrophage	NNS
cord-336510-qzm9wgde	365	22	[	[	-LRB-
cord-336510-qzm9wgde	365	23	17	17	CD
cord-336510-qzm9wgde	365	24	,	,	,
cord-336510-qzm9wgde	365	25	303	303	CD
cord-336510-qzm9wgde	365	26	,	,	,
cord-336510-qzm9wgde	365	27	304	304	CD
cord-336510-qzm9wgde	365	28	]	]	-RRB-
cord-336510-qzm9wgde	365	29	.	.	.
cord-336510-qzm9wgde	366	1	In	in	IN
cord-336510-qzm9wgde	366	2	PBMCderived	pbmcderived	JJ
cord-336510-qzm9wgde	366	3	dendritic	dendritic	JJ
cord-336510-qzm9wgde	366	4	cells	cell	NNS
cord-336510-qzm9wgde	366	5	,	,	,
cord-336510-qzm9wgde	366	6	however	however	RB
cord-336510-qzm9wgde	366	7	,	,	,
cord-336510-qzm9wgde	366	8	the	the	DT
cord-336510-qzm9wgde	366	9	cellular	cellular	JJ
cord-336510-qzm9wgde	366	10	mannose	mannose	NN
cord-336510-qzm9wgde	366	11	receptor	receptor	NN
cord-336510-qzm9wgde	366	12	was	be	VBD
cord-336510-qzm9wgde	366	13	shown	show	VBN
cord-336510-qzm9wgde	366	14	to	to	TO
cord-336510-qzm9wgde	366	15	be	be	VB
cord-336510-qzm9wgde	366	16	involved	involve	VBN
cord-336510-qzm9wgde	366	17	[	[	-LRB-
cord-336510-qzm9wgde	366	18	299	299	CD
cord-336510-qzm9wgde	366	19	,	,	,
cord-336510-qzm9wgde	366	20	305	305	CD
cord-336510-qzm9wgde	366	21	]	]	-RRB-
cord-336510-qzm9wgde	366	22	.	.	.
cord-336510-qzm9wgde	367	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	367	2	,	,	,
cord-336510-qzm9wgde	367	3	different	different	JJ
cord-336510-qzm9wgde	367	4	Toll	toll	NN
cord-336510-qzm9wgde	367	5	-	-	HYPH
cord-336510-qzm9wgde	367	6	like	like	JJ
cord-336510-qzm9wgde	367	7	receptors	receptor	NNS
cord-336510-qzm9wgde	367	8	(	(	-LRB-
cord-336510-qzm9wgde	367	9	TLRs	TLRs	NNP
cord-336510-qzm9wgde	367	10	)	)	-RRB-
cord-336510-qzm9wgde	367	11	have	have	VBP
cord-336510-qzm9wgde	367	12	been	be	VBN
cord-336510-qzm9wgde	367	13	shown	show	VBN
cord-336510-qzm9wgde	367	14	to	to	TO
cord-336510-qzm9wgde	367	15	react	react	VB
cord-336510-qzm9wgde	367	16	with	with	IN
cord-336510-qzm9wgde	367	17	HSV	HSV	NNP
cord-336510-qzm9wgde	367	18	[	[	-LRB-
cord-336510-qzm9wgde	367	19	306	306	CD
cord-336510-qzm9wgde	367	20	]	]	-RRB-
cord-336510-qzm9wgde	367	21	.	.	.
cord-336510-qzm9wgde	368	1	TLRs	TLRs	NNP
cord-336510-qzm9wgde	368	2	are	be	VBP
cord-336510-qzm9wgde	368	3	transmembrane	transmembrane	NN
cord-336510-qzm9wgde	368	4	pattern	pattern	NN
cord-336510-qzm9wgde	368	5	recognition	recognition	NN
cord-336510-qzm9wgde	368	6	receptors	receptor	NNS
cord-336510-qzm9wgde	368	7	(	(	-LRB-
cord-336510-qzm9wgde	368	8	PRRs	PRRs	NNP
cord-336510-qzm9wgde	368	9	)	)	-RRB-
cord-336510-qzm9wgde	368	10	that	that	WDT
cord-336510-qzm9wgde	368	11	detect	detect	VBP
cord-336510-qzm9wgde	368	12	redundant	redundant	JJ
cord-336510-qzm9wgde	368	13	microbial	microbial	JJ
cord-336510-qzm9wgde	368	14	molecular	molecular	JJ
cord-336510-qzm9wgde	368	15	motives	motive	NNS
cord-336510-qzm9wgde	368	16	and	and	CC
cord-336510-qzm9wgde	368	17	induce	induce	VB
cord-336510-qzm9wgde	368	18	antiviral	antiviral	JJ
cord-336510-qzm9wgde	368	19	and	and	CC
cord-336510-qzm9wgde	368	20	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	368	21	cytokines	cytokine	NNS
cord-336510-qzm9wgde	368	22	in	in	IN
cord-336510-qzm9wgde	368	23	response	response	NN
cord-336510-qzm9wgde	368	24	to	to	IN
cord-336510-qzm9wgde	368	25	alerting	alert	VBG
cord-336510-qzm9wgde	368	26	signals	signal	NNS
cord-336510-qzm9wgde	368	27	.	.	.
cord-336510-qzm9wgde	369	1	In	in	IN
cord-336510-qzm9wgde	369	2	dendritic	dendritic	JJ
cord-336510-qzm9wgde	369	3	cells	cell	NNS
cord-336510-qzm9wgde	369	4	,	,	,
cord-336510-qzm9wgde	369	5	TLR9-signalling	TLR9-signalling	NNP
cord-336510-qzm9wgde	369	6	,	,	,
cord-336510-qzm9wgde	369	7	induced	induce	VBN
cord-336510-qzm9wgde	369	8	by	by	IN
cord-336510-qzm9wgde	369	9	the	the	DT
cord-336510-qzm9wgde	369	10	GC	GC	NNP
cord-336510-qzm9wgde	369	11	-	-	HYPH
cord-336510-qzm9wgde	369	12	rich	rich	JJ
cord-336510-qzm9wgde	369	13	HSV	HSV	NNP
cord-336510-qzm9wgde	369	14	genome	genome	NN
cord-336510-qzm9wgde	369	15	,	,	,
cord-336510-qzm9wgde	369	16	has	have	VBZ
cord-336510-qzm9wgde	369	17	been	be	VBN
cord-336510-qzm9wgde	369	18	shown	show	VBN
cord-336510-qzm9wgde	369	19	to	to	TO
cord-336510-qzm9wgde	369	20	govern	govern	VB
cord-336510-qzm9wgde	369	21	the	the	DT
cord-336510-qzm9wgde	369	22	induction	induction	NN
cord-336510-qzm9wgde	369	23	of	of	IN
cord-336510-qzm9wgde	369	24	IFN	IFN	NNP
cord-336510-qzm9wgde	369	25	-	-	HYPH
cord-336510-qzm9wgde	369	26	α	α	NNP
cord-336510-qzm9wgde	369	27	/	/	SYM
cord-336510-qzm9wgde	369	28	β	β	NN
cord-336510-qzm9wgde	369	29	,	,	,
cord-336510-qzm9wgde	369	30	but	but	CC
cord-336510-qzm9wgde	369	31	TLR9-KO	tlr9-ko	DT
cord-336510-qzm9wgde	369	32	mice	mouse	NNS
cord-336510-qzm9wgde	369	33	are	be	VBP
cord-336510-qzm9wgde	369	34	still	still	RB
cord-336510-qzm9wgde	369	35	capable	capable	JJ
cord-336510-qzm9wgde	369	36	of	of	IN
cord-336510-qzm9wgde	369	37	controlling	control	VBG
cord-336510-qzm9wgde	369	38	HSV	HSV	NNP
cord-336510-qzm9wgde	369	39	infections	infection	NNS
cord-336510-qzm9wgde	369	40	in	in	IN
cord-336510-qzm9wgde	369	41	vivo	vivo	NN
cord-336510-qzm9wgde	369	42	[	[	-LRB-
cord-336510-qzm9wgde	369	43	307	307	CD
cord-336510-qzm9wgde	369	44	]	]	-RRB-
cord-336510-qzm9wgde	369	45	[	[	-LRB-
cord-336510-qzm9wgde	369	46	308	308	CD
cord-336510-qzm9wgde	369	47	]	]	-RRB-
cord-336510-qzm9wgde	369	48	[	[	-LRB-
cord-336510-qzm9wgde	369	49	309	309	CD
cord-336510-qzm9wgde	369	50	]	]	-RRB-
cord-336510-qzm9wgde	369	51	.	.	.
cord-336510-qzm9wgde	370	1	However	however	RB
cord-336510-qzm9wgde	370	2	,	,	,
cord-336510-qzm9wgde	370	3	in	in	IN
cord-336510-qzm9wgde	370	4	mouse	mouse	NN
cord-336510-qzm9wgde	370	5	macrophages	macrophage	VBZ
cord-336510-qzm9wgde	370	6	the	the	DT
cord-336510-qzm9wgde	370	7	TLRs	TLRs	NNPS
cord-336510-qzm9wgde	370	8	do	do	VBP
cord-336510-qzm9wgde	370	9	not	not	RB
cord-336510-qzm9wgde	370	10	seem	seem	VB
cord-336510-qzm9wgde	370	11	to	to	TO
cord-336510-qzm9wgde	370	12	be	be	VB
cord-336510-qzm9wgde	370	13	crucial	crucial	JJ
cord-336510-qzm9wgde	370	14	for	for	IN
cord-336510-qzm9wgde	370	15	IFN	IFN	NNP
cord-336510-qzm9wgde	370	16	-	-	HYPH
cord-336510-qzm9wgde	370	17	α	α	NNP
cord-336510-qzm9wgde	370	18	/	/	SYM
cord-336510-qzm9wgde	370	19	β	β	NN
cord-336510-qzm9wgde	370	20	induction	induction	NN
cord-336510-qzm9wgde	370	21	upon	upon	IN
cord-336510-qzm9wgde	370	22	HSV	HSV	NNP
cord-336510-qzm9wgde	370	23	infection	infection	NN
cord-336510-qzm9wgde	370	24	[	[	-LRB-
cord-336510-qzm9wgde	370	25	304	304	CD
cord-336510-qzm9wgde	370	26	]	]	-RRB-
cord-336510-qzm9wgde	370	27	.	.	.
cord-336510-qzm9wgde	371	1	This	this	DT
cord-336510-qzm9wgde	371	2	is	be	VBZ
cord-336510-qzm9wgde	371	3	in	in	IN
cord-336510-qzm9wgde	371	4	agreement	agreement	NN
cord-336510-qzm9wgde	371	5	with	with	IN
cord-336510-qzm9wgde	371	6	the	the	DT
cord-336510-qzm9wgde	371	7	observation	observation	NN
cord-336510-qzm9wgde	371	8	that	that	IN
cord-336510-qzm9wgde	371	9	the	the	DT
cord-336510-qzm9wgde	371	10	majority	majority	NN
cord-336510-qzm9wgde	371	11	of	of	IN
cord-336510-qzm9wgde	371	12	IFN	IFN	NNP
cord-336510-qzm9wgde	371	13	-	-	HYPH
cord-336510-qzm9wgde	371	14	α	α	NNP
cord-336510-qzm9wgde	371	15	/	/	SYM
cord-336510-qzm9wgde	371	16	β	β	NN
cord-336510-qzm9wgde	371	17	produced	produce	VBN
cord-336510-qzm9wgde	371	18	by	by	IN
cord-336510-qzm9wgde	371	19	spleen	spleen	NN
cord-336510-qzm9wgde	371	20	cells	cell	NNS
cord-336510-qzm9wgde	371	21	and	and	CC
cord-336510-qzm9wgde	371	22	dendritic	dendritic	JJ
cord-336510-qzm9wgde	371	23	cells	cell	NNS
cord-336510-qzm9wgde	371	24	and	and	CC
cord-336510-qzm9wgde	371	25	the	the	DT
cord-336510-qzm9wgde	371	26	total	total	JJ
cord-336510-qzm9wgde	371	27	production	production	NN
cord-336510-qzm9wgde	371	28	from	from	IN
cord-336510-qzm9wgde	371	29	bone	bone	NN
cord-336510-qzm9wgde	371	30	marrow	marrow	NN
cord-336510-qzm9wgde	371	31	macrophages	macrophage	NNS
cord-336510-qzm9wgde	371	32	was	be	VBD
cord-336510-qzm9wgde	371	33	independent	independent	JJ
cord-336510-qzm9wgde	371	34	of	of	IN
cord-336510-qzm9wgde	371	35	TLR9	TLR9	NNP
cord-336510-qzm9wgde	371	36	or	or	CC
cord-336510-qzm9wgde	371	37	MyD88	MyD88	NNP
cord-336510-qzm9wgde	371	38	,	,	,
cord-336510-qzm9wgde	371	39	which	which	WDT
cord-336510-qzm9wgde	371	40	is	be	VBZ
cord-336510-qzm9wgde	371	41	necessary	necessary	JJ
cord-336510-qzm9wgde	371	42	for	for	IN
cord-336510-qzm9wgde	371	43	signalling	signal	VBG
cord-336510-qzm9wgde	371	44	by	by	IN
cord-336510-qzm9wgde	371	45	most	most	JJS
cord-336510-qzm9wgde	371	46	TLRs	tlr	NNS
cord-336510-qzm9wgde	371	47	[	[	-LRB-
cord-336510-qzm9wgde	371	48	308	308	CD
cord-336510-qzm9wgde	371	49	]	]	-RRB-
cord-336510-qzm9wgde	371	50	.	.	.
cord-336510-qzm9wgde	372	1	In	in	IN
cord-336510-qzm9wgde	372	2	this	this	DT
cord-336510-qzm9wgde	372	3	study	study	NN
cord-336510-qzm9wgde	372	4	,	,	,
cord-336510-qzm9wgde	372	5	heat	heat	NN
cord-336510-qzm9wgde	372	6	inactivated	inactivate	VBN
cord-336510-qzm9wgde	372	7	virus	virus	NN
cord-336510-qzm9wgde	372	8	was	be	VBD
cord-336510-qzm9wgde	372	9	shown	show	VBN
cord-336510-qzm9wgde	372	10	still	still	RB
cord-336510-qzm9wgde	372	11	to	to	TO
cord-336510-qzm9wgde	372	12	induce	induce	VB
cord-336510-qzm9wgde	372	13	IFN	IFN	NNP
cord-336510-qzm9wgde	372	14	-	-	HYPH
cord-336510-qzm9wgde	372	15	α	α	NNP
cord-336510-qzm9wgde	372	16	/	/	SYM
cord-336510-qzm9wgde	372	17	β	β	NN
cord-336510-qzm9wgde	372	18	in	in	IN
cord-336510-qzm9wgde	372	19	cells	cell	NNS
cord-336510-qzm9wgde	372	20	utilizing	utilize	VBG
cord-336510-qzm9wgde	372	21	TLR9	TLR9	NNP
cord-336510-qzm9wgde	372	22	.	.	.
cord-336510-qzm9wgde	373	1	As	as	IN
cord-336510-qzm9wgde	373	2	resident	resident	JJ
cord-336510-qzm9wgde	373	3	peritoneal	peritoneal	NN
cord-336510-qzm9wgde	373	4	macrophages	macrophage	NNS
cord-336510-qzm9wgde	373	5	do	do	VBP
cord-336510-qzm9wgde	373	6	not	not	RB
cord-336510-qzm9wgde	373	7	produce	produce	VB
cord-336510-qzm9wgde	373	8	IFN	IFN	NNP
cord-336510-qzm9wgde	373	9	-	-	HYPH
cord-336510-qzm9wgde	373	10	α	α	NNP
cord-336510-qzm9wgde	373	11	/	/	SYM
cord-336510-qzm9wgde	373	12	β	β	NN
cord-336510-qzm9wgde	373	13	in	in	IN
cord-336510-qzm9wgde	373	14	response	response	NN
cord-336510-qzm9wgde	373	15	to	to	IN
cord-336510-qzm9wgde	373	16	even	even	RB
cord-336510-qzm9wgde	373	17	high	high	JJ
cord-336510-qzm9wgde	373	18	doses	dose	NNS
cord-336510-qzm9wgde	373	19	of	of	IN
cord-336510-qzm9wgde	373	20	heat	heat	NN
cord-336510-qzm9wgde	373	21	inactivated	inactivate	VBN
cord-336510-qzm9wgde	373	22	HSV	HSV	NNP
cord-336510-qzm9wgde	373	23	,	,	,
cord-336510-qzm9wgde	373	24	this	this	DT
cord-336510-qzm9wgde	373	25	gives	give	VBZ
cord-336510-qzm9wgde	373	26	an	an	DT
cord-336510-qzm9wgde	373	27	additional	additional	JJ
cord-336510-qzm9wgde	373	28	indication	indication	NN
cord-336510-qzm9wgde	373	29	of	of	IN
cord-336510-qzm9wgde	373	30	independency	independency	NN
cord-336510-qzm9wgde	373	31	from	from	IN
cord-336510-qzm9wgde	373	32	TLR9	TLR9	NNP
cord-336510-qzm9wgde	373	33	of	of	IN
cord-336510-qzm9wgde	373	34	IFN	IFN	NNP
cord-336510-qzm9wgde	373	35	-	-	HYPH
cord-336510-qzm9wgde	373	36	α	α	NNP
cord-336510-qzm9wgde	373	37	/	/	SYM
cord-336510-qzm9wgde	373	38	β	β	NN
cord-336510-qzm9wgde	373	39	production	production	NN
cord-336510-qzm9wgde	373	40	in	in	IN
cord-336510-qzm9wgde	373	41	macrophages	macrophage	NNS
cord-336510-qzm9wgde	373	42	[	[	-LRB-
cord-336510-qzm9wgde	373	43	300	300	CD
cord-336510-qzm9wgde	373	44	]	]	-RRB-
cord-336510-qzm9wgde	373	45	.	.	.
cord-336510-qzm9wgde	374	1	Moreover	moreover	RB
cord-336510-qzm9wgde	374	2	,	,	,
cord-336510-qzm9wgde	374	3	efficient	efficient	JJ
cord-336510-qzm9wgde	374	4	induction	induction	NN
cord-336510-qzm9wgde	374	5	of	of	IN
cord-336510-qzm9wgde	374	6	IFN	IFN	NNP
cord-336510-qzm9wgde	374	7	-	-	HYPH
cord-336510-qzm9wgde	374	8	α	α	NNP
cord-336510-qzm9wgde	374	9	/	/	SYM
cord-336510-qzm9wgde	374	10	β	β	NN
cord-336510-qzm9wgde	374	11	by	by	IN
cord-336510-qzm9wgde	374	12	HSV	HSV	NNP
cord-336510-qzm9wgde	374	13	in	in	IN
cord-336510-qzm9wgde	374	14	macrophages	macrophage	NNS
cord-336510-qzm9wgde	374	15	required	require	VBD
cord-336510-qzm9wgde	374	16	dsRNA	dsrna	RB
cord-336510-qzm9wgde	374	17	-	-	HYPH
cord-336510-qzm9wgde	374	18	activated	activate	VBN
cord-336510-qzm9wgde	374	19	protein	protein	NN
cord-336510-qzm9wgde	374	20	kinase	kinase	NN
cord-336510-qzm9wgde	374	21	(	(	-LRB-
cord-336510-qzm9wgde	374	22	PKR	PKR	NNP
cord-336510-qzm9wgde	374	23	)	)	-RRB-
cord-336510-qzm9wgde	374	24	activity	activity	NN
cord-336510-qzm9wgde	374	25	and	and	CC
cord-336510-qzm9wgde	374	26	infectivity	infectivity	NN
cord-336510-qzm9wgde	374	27	of	of	IN
cord-336510-qzm9wgde	374	28	the	the	DT
cord-336510-qzm9wgde	374	29	virus	virus	NN
cord-336510-qzm9wgde	374	30	[	[	-LRB-
cord-336510-qzm9wgde	374	31	304	304	CD
cord-336510-qzm9wgde	374	32	]	]	-RRB-
cord-336510-qzm9wgde	374	33	.	.	.
cord-336510-qzm9wgde	375	1	This	this	DT
cord-336510-qzm9wgde	375	2	is	be	VBZ
cord-336510-qzm9wgde	375	3	in	in	IN
cord-336510-qzm9wgde	375	4	agreement	agreement	NN
cord-336510-qzm9wgde	375	5	with	with	IN
cord-336510-qzm9wgde	375	6	the	the	DT
cord-336510-qzm9wgde	375	7	observation	observation	NN
cord-336510-qzm9wgde	375	8	that	that	IN
cord-336510-qzm9wgde	375	9	dsRNA	dsrna	NN
cord-336510-qzm9wgde	375	10	,	,	,
cord-336510-qzm9wgde	375	11	which	which	WDT
cord-336510-qzm9wgde	375	12	is	be	VBZ
cord-336510-qzm9wgde	375	13	produced	produce	VBN
cord-336510-qzm9wgde	375	14	by	by	IN
cord-336510-qzm9wgde	375	15	most	most	JJS
cord-336510-qzm9wgde	375	16	viruses	virus	NNS
cord-336510-qzm9wgde	375	17	during	during	IN
cord-336510-qzm9wgde	375	18	replication	replication	NN
cord-336510-qzm9wgde	375	19	,	,	,
cord-336510-qzm9wgde	375	20	induces	induce	VBZ
cord-336510-qzm9wgde	375	21	IFN	IFN	NNP
cord-336510-qzm9wgde	375	22	through	through	IN
cord-336510-qzm9wgde	375	23	PKR	PKR	NNP
cord-336510-qzm9wgde	375	24	,	,	,
cord-336510-qzm9wgde	375	25	and	and	CC
cord-336510-qzm9wgde	375	26	not	not	RB
cord-336510-qzm9wgde	375	27	through	through	IN
cord-336510-qzm9wgde	375	28	TLR3	TLR3	NNP
cord-336510-qzm9wgde	375	29	,	,	,
cord-336510-qzm9wgde	375	30	which	which	WDT
cord-336510-qzm9wgde	375	31	also	also	RB
cord-336510-qzm9wgde	375	32	binds	bind	VBZ
cord-336510-qzm9wgde	375	33	dsRNA	dsRNA	VBG
cord-336510-qzm9wgde	375	34	[	[	-LRB-
cord-336510-qzm9wgde	375	35	310	310	CD
cord-336510-qzm9wgde	375	36	]	]	-RRB-
cord-336510-qzm9wgde	375	37	.	.	.
cord-336510-qzm9wgde	376	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	376	2	,	,	,
cord-336510-qzm9wgde	376	3	another	another	DT
cord-336510-qzm9wgde	376	4	mechanism	mechanism	NN
cord-336510-qzm9wgde	376	5	of	of	IN
cord-336510-qzm9wgde	376	6	IFN	IFN	NNP
cord-336510-qzm9wgde	376	7	induction	induction	NN
cord-336510-qzm9wgde	376	8	by	by	IN
cord-336510-qzm9wgde	376	9	dsRNA	dsRNA	NNS
cord-336510-qzm9wgde	376	10	through	through	IN
cord-336510-qzm9wgde	376	11	a	a	DT
cord-336510-qzm9wgde	376	12	RNA	RNA	NNP
cord-336510-qzm9wgde	376	13	helicase	helicase	NN
cord-336510-qzm9wgde	376	14	has	have	VBZ
cord-336510-qzm9wgde	376	15	been	be	VBN
cord-336510-qzm9wgde	376	16	proposed	propose	VBN
cord-336510-qzm9wgde	376	17	[	[	-LRB-
cord-336510-qzm9wgde	376	18	311	311	CD
cord-336510-qzm9wgde	376	19	]	]	-RRB-
cord-336510-qzm9wgde	376	20	.	.	.
cord-336510-qzm9wgde	377	1	The	the	DT
cord-336510-qzm9wgde	377	2	different	different	JJ
cord-336510-qzm9wgde	377	3	induction	induction	NN
cord-336510-qzm9wgde	377	4	patterns	pattern	NNS
cord-336510-qzm9wgde	377	5	in	in	IN
cord-336510-qzm9wgde	377	6	different	different	JJ
cord-336510-qzm9wgde	377	7	cells	cell	NNS
cord-336510-qzm9wgde	377	8	types	type	NNS
cord-336510-qzm9wgde	377	9	,	,	,
cord-336510-qzm9wgde	377	10	and	and	CC
cord-336510-qzm9wgde	377	11	the	the	DT
cord-336510-qzm9wgde	377	12	fact	fact	NN
cord-336510-qzm9wgde	377	13	that	that	IN
cord-336510-qzm9wgde	377	14	IFN	IFN	NNP
cord-336510-qzm9wgde	377	15	-	-	HYPH
cord-336510-qzm9wgde	377	16	α	α	NNP
cord-336510-qzm9wgde	377	17	/	/	SYM
cord-336510-qzm9wgde	377	18	β	β	NN
cord-336510-qzm9wgde	377	19	seems	seem	VBZ
cord-336510-qzm9wgde	377	20	largely	largely	RB
cord-336510-qzm9wgde	377	21	to	to	TO
cord-336510-qzm9wgde	377	22	be	be	VB
cord-336510-qzm9wgde	377	23	induced	induce	VBN
cord-336510-qzm9wgde	377	24	by	by	IN
cord-336510-qzm9wgde	377	25	other	other	JJ
cord-336510-qzm9wgde	377	26	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	377	27	than	than	IN
cord-336510-qzm9wgde	377	28	TLRs	tlr	NNS
cord-336510-qzm9wgde	377	29	,	,	,
cord-336510-qzm9wgde	377	30	explain	explain	VBP
cord-336510-qzm9wgde	377	31	the	the	DT
cord-336510-qzm9wgde	377	32	fact	fact	NN
cord-336510-qzm9wgde	377	33	that	that	IN
cord-336510-qzm9wgde	377	34	knocking	knock	VBG
cord-336510-qzm9wgde	377	35	out	out	RP
cord-336510-qzm9wgde	377	36	TLR	tlr	NN
cord-336510-qzm9wgde	377	37	-	-	HYPH
cord-336510-qzm9wgde	377	38	signalling	signalling	NN
cord-336510-qzm9wgde	377	39	by	by	IN
cord-336510-qzm9wgde	377	40	MyD88	MyD88	NNS
cord-336510-qzm9wgde	377	41	did	do	VBD
cord-336510-qzm9wgde	377	42	not	not	RB
cord-336510-qzm9wgde	377	43	influence	influence	VB
cord-336510-qzm9wgde	377	44	the	the	DT
cord-336510-qzm9wgde	377	45	in	in	IN
cord-336510-qzm9wgde	377	46	vivo	vivo	NN
cord-336510-qzm9wgde	377	47	infection	infection	NN
cord-336510-qzm9wgde	377	48	with	with	IN
cord-336510-qzm9wgde	377	49	HSV	HSV	NNP
cord-336510-qzm9wgde	377	50	in	in	IN
cord-336510-qzm9wgde	377	51	mice	mouse	NNS
cord-336510-qzm9wgde	377	52	[	[	-LRB-
cord-336510-qzm9wgde	377	53	309	309	CD
cord-336510-qzm9wgde	377	54	]	]	-RRB-
cord-336510-qzm9wgde	377	55	.	.	.
cord-336510-qzm9wgde	378	1	Other	other	JJ
cord-336510-qzm9wgde	378	2	TLRs	tlr	NNS
cord-336510-qzm9wgde	378	3	have	have	VBP
cord-336510-qzm9wgde	378	4	also	also	RB
cord-336510-qzm9wgde	378	5	been	be	VBN
cord-336510-qzm9wgde	378	6	shown	show	VBN
cord-336510-qzm9wgde	378	7	to	to	TO
cord-336510-qzm9wgde	378	8	mediate	mediate	VB
cord-336510-qzm9wgde	378	9	signals	signal	NNS
cord-336510-qzm9wgde	378	10	in	in	IN
cord-336510-qzm9wgde	378	11	HSV	HSV	NNP
cord-336510-qzm9wgde	378	12	infections	infection	NNS
cord-336510-qzm9wgde	378	13	.	.	.
cord-336510-qzm9wgde	379	1	In	in	IN
cord-336510-qzm9wgde	379	2	HSV	HSV	NNP
cord-336510-qzm9wgde	379	3	encephalitis	encephalitis	RB
cord-336510-qzm9wgde	379	4	in	in	IN
cord-336510-qzm9wgde	379	5	TLR2-KO	TLR2-KO	NNP
cord-336510-qzm9wgde	379	6	mice	mice	NN
cord-336510-qzm9wgde	379	7	,	,	,
cord-336510-qzm9wgde	379	8	viral	viral	JJ
cord-336510-qzm9wgde	379	9	replication	replication	NN
cord-336510-qzm9wgde	379	10	seemed	seem	VBD
cord-336510-qzm9wgde	379	11	unchanged	unchanged	JJ
cord-336510-qzm9wgde	379	12	or	or	CC
cord-336510-qzm9wgde	379	13	slightly	slightly	RB
cord-336510-qzm9wgde	379	14	increased	increase	VBN
cord-336510-qzm9wgde	379	15	during	during	IN
cord-336510-qzm9wgde	379	16	the	the	DT
cord-336510-qzm9wgde	379	17	first	first	JJ
cord-336510-qzm9wgde	379	18	4	4	CD
cord-336510-qzm9wgde	379	19	days	day	NNS
cord-336510-qzm9wgde	379	20	of	of	IN
cord-336510-qzm9wgde	379	21	infection	infection	NN
cord-336510-qzm9wgde	379	22	,	,	,
cord-336510-qzm9wgde	379	23	and	and	CC
cord-336510-qzm9wgde	379	24	the	the	DT
cord-336510-qzm9wgde	379	25	production	production	NN
cord-336510-qzm9wgde	379	26	of	of	IN
cord-336510-qzm9wgde	379	27	IL-6	IL-6	NNP
cord-336510-qzm9wgde	379	28	and	and	CC
cord-336510-qzm9wgde	379	29	monocyte	monocyte	NNP
cord-336510-qzm9wgde	379	30	chemoattractant	chemoattractant	NNP
cord-336510-qzm9wgde	379	31	protein	protein	NNP
cord-336510-qzm9wgde	379	32	1	1	CD
cord-336510-qzm9wgde	379	33	were	be	VBD
cord-336510-qzm9wgde	379	34	impaired	impair	VBN
cord-336510-qzm9wgde	379	35	,	,	,
cord-336510-qzm9wgde	379	36	but	but	CC
cord-336510-qzm9wgde	379	37	interestingly	interestingly	RB
cord-336510-qzm9wgde	379	38	pathological	pathological	JJ
cord-336510-qzm9wgde	379	39	changes	change	NNS
cord-336510-qzm9wgde	379	40	and	and	CC
cord-336510-qzm9wgde	379	41	mortality	mortality	NN
cord-336510-qzm9wgde	379	42	were	be	VBD
cord-336510-qzm9wgde	379	43	reduced	reduce	VBN
cord-336510-qzm9wgde	379	44	[	[	-LRB-
cord-336510-qzm9wgde	379	45	134	134	CD
cord-336510-qzm9wgde	379	46	]	]	-RRB-
cord-336510-qzm9wgde	379	47	.	.	.
cord-336510-qzm9wgde	380	1	In	in	IN
cord-336510-qzm9wgde	380	2	relation	relation	NN
cord-336510-qzm9wgde	380	3	to	to	IN
cord-336510-qzm9wgde	380	4	the	the	DT
cord-336510-qzm9wgde	380	5	X	x	NN
cord-336510-qzm9wgde	380	6	-	-	HYPH
cord-336510-qzm9wgde	380	7	linked	link	VBN
cord-336510-qzm9wgde	380	8	resistance	resistance	NN
cord-336510-qzm9wgde	380	9	pattern	pattern	NN
cord-336510-qzm9wgde	380	10	of	of	IN
cord-336510-qzm9wgde	380	11	HSV	HSV	NNP
cord-336510-qzm9wgde	380	12	infection	infection	NN
cord-336510-qzm9wgde	380	13	and	and	CC
cord-336510-qzm9wgde	380	14	IFN	IFN	NNP
cord-336510-qzm9wgde	380	15	production	production	NN
cord-336510-qzm9wgde	380	16	upon	upon	IN
cord-336510-qzm9wgde	380	17	HSV	HSV	NNP
cord-336510-qzm9wgde	380	18	infection	infection	NN
cord-336510-qzm9wgde	380	19	,	,	,
cord-336510-qzm9wgde	380	20	it	-PRON-	PRP
cord-336510-qzm9wgde	380	21	is	be	VBZ
cord-336510-qzm9wgde	380	22	interesting	interesting	JJ
cord-336510-qzm9wgde	380	23	that	that	IN
cord-336510-qzm9wgde	380	24	some	some	DT
cord-336510-qzm9wgde	380	25	of	of	IN
cord-336510-qzm9wgde	380	26	the	the	DT
cord-336510-qzm9wgde	380	27	TLRs	tlr	NNS
cord-336510-qzm9wgde	380	28	are	be	VBP
cord-336510-qzm9wgde	380	29	coded	code	VBN
cord-336510-qzm9wgde	380	30	from	from	IN
cord-336510-qzm9wgde	380	31	the	the	DT
cord-336510-qzm9wgde	380	32	Xchromosome	Xchromosome	NNP
cord-336510-qzm9wgde	380	33	[	[	-LRB-
cord-336510-qzm9wgde	380	34	312	312	CD
cord-336510-qzm9wgde	380	35	]	]	-RRB-
cord-336510-qzm9wgde	380	36	.	.	.
cord-336510-qzm9wgde	381	1	These	these	DT
cord-336510-qzm9wgde	381	2	are	be	VBP
cord-336510-qzm9wgde	381	3	the	the	DT
cord-336510-qzm9wgde	381	4	TLR7	TLR7	NNP
cord-336510-qzm9wgde	381	5	and	and	CC
cord-336510-qzm9wgde	381	6	TLR8	TLR8	NNP
cord-336510-qzm9wgde	381	7	,	,	,
cord-336510-qzm9wgde	381	8	which	which	WDT
cord-336510-qzm9wgde	381	9	are	be	VBP
cord-336510-qzm9wgde	381	10	triggered	trigger	VBN
cord-336510-qzm9wgde	381	11	by	by	IN
cord-336510-qzm9wgde	381	12	guanosine	guanosine	NN
cord-336510-qzm9wgde	381	13	-	-	HYPH
cord-336510-qzm9wgde	381	14	or	or	CC
cord-336510-qzm9wgde	381	15	uridine	uridine	NN
cord-336510-qzm9wgde	381	16	-	-	HYPH
cord-336510-qzm9wgde	381	17	rich	rich	JJ
cord-336510-qzm9wgde	381	18	ssRNA	ssRNA	''
cord-336510-qzm9wgde	381	19	in	in	IN
cord-336510-qzm9wgde	381	20	the	the	DT
cord-336510-qzm9wgde	381	21	endosomal	endosomal	NNP
cord-336510-qzm9wgde	381	22	compartment	compartment	NN
cord-336510-qzm9wgde	381	23	of	of	IN
cord-336510-qzm9wgde	381	24	cells	cell	NNS
cord-336510-qzm9wgde	381	25	[	[	-LRB-
cord-336510-qzm9wgde	381	26	313	313	CD
cord-336510-qzm9wgde	381	27	,	,	,
cord-336510-qzm9wgde	381	28	314	314	CD
cord-336510-qzm9wgde	381	29	]	]	-RRB-
cord-336510-qzm9wgde	381	30	.	.	.
cord-336510-qzm9wgde	382	1	There	there	EX
cord-336510-qzm9wgde	382	2	are	be	VBP
cord-336510-qzm9wgde	382	3	,	,	,
cord-336510-qzm9wgde	382	4	however	however	RB
cord-336510-qzm9wgde	382	5	,	,	,
cord-336510-qzm9wgde	382	6	no	no	DT
cord-336510-qzm9wgde	382	7	indications	indication	NNS
cord-336510-qzm9wgde	382	8	that	that	IN
cord-336510-qzm9wgde	382	9	this	this	DT
cord-336510-qzm9wgde	382	10	pathway	pathway	NN
cord-336510-qzm9wgde	382	11	is	be	VBZ
cord-336510-qzm9wgde	382	12	implicated	implicate	VBN
cord-336510-qzm9wgde	382	13	in	in	IN
cord-336510-qzm9wgde	382	14	IFN	IFN	NNP
cord-336510-qzm9wgde	382	15	induction	induction	NN
cord-336510-qzm9wgde	382	16	in	in	IN
cord-336510-qzm9wgde	382	17	cells	cell	NNS
cord-336510-qzm9wgde	382	18	during	during	IN
cord-336510-qzm9wgde	382	19	HSV	HSV	NNP
cord-336510-qzm9wgde	382	20	infection	infection	NN
cord-336510-qzm9wgde	382	21	,	,	,
cord-336510-qzm9wgde	382	22	but	but	CC
cord-336510-qzm9wgde	382	23	the	the	DT
cord-336510-qzm9wgde	382	24	question	question	NN
cord-336510-qzm9wgde	382	25	has	have	VBZ
cord-336510-qzm9wgde	382	26	still	still	RB
cord-336510-qzm9wgde	382	27	not	not	RB
cord-336510-qzm9wgde	382	28	been	be	VBN
cord-336510-qzm9wgde	382	29	directly	directly	RB
cord-336510-qzm9wgde	382	30	addressed	address	VBN
cord-336510-qzm9wgde	382	31	.	.	.
cord-336510-qzm9wgde	383	1	Regulation	regulation	NN
cord-336510-qzm9wgde	383	2	of	of	IN
cord-336510-qzm9wgde	383	3	the	the	DT
cord-336510-qzm9wgde	383	4	IFN	IFN	NNP
cord-336510-qzm9wgde	383	5	-	-	HYPH
cord-336510-qzm9wgde	383	6	α	α	NNP
cord-336510-qzm9wgde	383	7	/	/	SYM
cord-336510-qzm9wgde	383	8	β	β	NN
cord-336510-qzm9wgde	383	9	gene	gene	NN
cord-336510-qzm9wgde	383	10	induction	induction	NN
cord-336510-qzm9wgde	383	11	is	be	VBZ
cord-336510-qzm9wgde	383	12	in	in	IN
cord-336510-qzm9wgde	383	13	part	part	NN
cord-336510-qzm9wgde	383	14	governed	govern	VBN
cord-336510-qzm9wgde	383	15	by	by	IN
cord-336510-qzm9wgde	383	16	activation	activation	NN
cord-336510-qzm9wgde	383	17	of	of	IN
cord-336510-qzm9wgde	383	18	the	the	DT
cord-336510-qzm9wgde	383	19	transcription	transcription	NN
cord-336510-qzm9wgde	383	20	factors	factor	NNS
cord-336510-qzm9wgde	383	21	IRF-3	IRF-3	NNP
cord-336510-qzm9wgde	384	1	and	and	CC
cord-336510-qzm9wgde	384	2	-7	-7	NNP
cord-336510-qzm9wgde	384	3	,	,	,
cord-336510-qzm9wgde	384	4	which	which	WDT
cord-336510-qzm9wgde	384	5	are	be	VBP
cord-336510-qzm9wgde	384	6	induced	induce	VBN
cord-336510-qzm9wgde	384	7	by	by	IN
cord-336510-qzm9wgde	384	8	IFN	IFN	NNP
cord-336510-qzm9wgde	384	9	-	-	HYPH
cord-336510-qzm9wgde	384	10	α	α	NNP
cord-336510-qzm9wgde	384	11	/	/	SYM
cord-336510-qzm9wgde	384	12	β	β	NN
cord-336510-qzm9wgde	384	13	itself	-PRON-	PRP
cord-336510-qzm9wgde	384	14	,	,	,
cord-336510-qzm9wgde	384	15	resulting	result	VBG
cord-336510-qzm9wgde	384	16	in	in	IN
cord-336510-qzm9wgde	384	17	a	a	DT
cord-336510-qzm9wgde	384	18	positive	positive	JJ
cord-336510-qzm9wgde	384	19	feed	feed	NN
cord-336510-qzm9wgde	384	20	back	back	RB
cord-336510-qzm9wgde	384	21	loop	loop	NN
cord-336510-qzm9wgde	384	22	,	,	,
cord-336510-qzm9wgde	384	23	an	an	DT
cord-336510-qzm9wgde	384	24	effect	effect	NN
cord-336510-qzm9wgde	384	25	which	which	WDT
cord-336510-qzm9wgde	384	26	has	have	VBZ
cord-336510-qzm9wgde	384	27	been	be	VBN
cord-336510-qzm9wgde	384	28	known	know	VBN
cord-336510-qzm9wgde	384	29	for	for	IN
cord-336510-qzm9wgde	384	30	years	year	NNS
cord-336510-qzm9wgde	384	31	without	without	IN
cord-336510-qzm9wgde	384	32	knowledge	knowledge	NN
cord-336510-qzm9wgde	384	33	of	of	IN
cord-336510-qzm9wgde	384	34	the	the	DT
cord-336510-qzm9wgde	384	35	signalling	signal	VBG
cord-336510-qzm9wgde	384	36	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	384	37	[	[	-LRB-
cord-336510-qzm9wgde	384	38	315	315	CD
cord-336510-qzm9wgde	384	39	]	]	-RRB-
cord-336510-qzm9wgde	384	40	[	[	-LRB-
cord-336510-qzm9wgde	384	41	316	316	CD
cord-336510-qzm9wgde	384	42	]	]	-RRB-
cord-336510-qzm9wgde	384	43	[	[	-LRB-
cord-336510-qzm9wgde	384	44	317	317	CD
cord-336510-qzm9wgde	384	45	]	]	-RRB-
cord-336510-qzm9wgde	384	46	.	.	.
cord-336510-qzm9wgde	385	1	Thus	thus	RB
cord-336510-qzm9wgde	385	2	,	,	,
cord-336510-qzm9wgde	385	3	one	one	CD
cord-336510-qzm9wgde	385	4	possible	possible	JJ
cord-336510-qzm9wgde	385	5	explanation	explanation	NN
cord-336510-qzm9wgde	385	6	for	for	IN
cord-336510-qzm9wgde	385	7	the	the	DT
cord-336510-qzm9wgde	385	8	genetic	genetic	JJ
cord-336510-qzm9wgde	385	9	differences	difference	NNS
cord-336510-qzm9wgde	385	10	in	in	IN
cord-336510-qzm9wgde	385	11	HSV	HSV	NNP
cord-336510-qzm9wgde	385	12	-	-	HYPH
cord-336510-qzm9wgde	385	13	induced	induce	VBN
cord-336510-qzm9wgde	385	14	IFN	IFN	NNP
cord-336510-qzm9wgde	385	15	-	-	HYPH
cord-336510-qzm9wgde	385	16	α	α	NNP
cord-336510-qzm9wgde	385	17	/	/	SYM
cord-336510-qzm9wgde	385	18	β	β	NN
cord-336510-qzm9wgde	385	19	production	production	NN
cord-336510-qzm9wgde	385	20	could	could	MD
cord-336510-qzm9wgde	385	21	be	be	VB
cord-336510-qzm9wgde	385	22	an	an	DT
cord-336510-qzm9wgde	385	23	elevated	elevated	JJ
cord-336510-qzm9wgde	385	24	physiological	physiological	JJ
cord-336510-qzm9wgde	385	25	level	level	NN
cord-336510-qzm9wgde	385	26	of	of	IN
cord-336510-qzm9wgde	385	27	this	this	DT
cord-336510-qzm9wgde	385	28	IFN	IFN	NNP
cord-336510-qzm9wgde	385	29	self	self	NN
cord-336510-qzm9wgde	385	30	-	-	HYPH
cord-336510-qzm9wgde	385	31	stimulating	stimulate	VBG
cord-336510-qzm9wgde	385	32	system	system	NN
cord-336510-qzm9wgde	385	33	[	[	-LRB-
cord-336510-qzm9wgde	385	34	318	318	CD
cord-336510-qzm9wgde	385	35	]	]	-RRB-
cord-336510-qzm9wgde	385	36	[	[	-LRB-
cord-336510-qzm9wgde	385	37	319	319	CD
cord-336510-qzm9wgde	385	38	]	]	-RRB-
cord-336510-qzm9wgde	385	39	[	[	-LRB-
cord-336510-qzm9wgde	385	40	320	320	CD
cord-336510-qzm9wgde	385	41	]	]	-RRB-
cord-336510-qzm9wgde	385	42	[	[	-LRB-
cord-336510-qzm9wgde	385	43	321	321	CD
cord-336510-qzm9wgde	385	44	]	]	-RRB-
cord-336510-qzm9wgde	385	45	.	.	.
cord-336510-qzm9wgde	386	1	An	an	DT
cord-336510-qzm9wgde	386	2	analysis	analysis	NN
cord-336510-qzm9wgde	386	3	of	of	IN
cord-336510-qzm9wgde	386	4	the	the	DT
cord-336510-qzm9wgde	386	5	levels	level	NNS
cord-336510-qzm9wgde	386	6	of	of	IN
cord-336510-qzm9wgde	386	7	IRF-3	IRF-3	NNP
cord-336510-qzm9wgde	386	8	and	and	CC
cord-336510-qzm9wgde	386	9	-7	-7	NNP
cord-336510-qzm9wgde	386	10	in	in	IN
cord-336510-qzm9wgde	386	11	normal	normal	JJ
cord-336510-qzm9wgde	386	12	macrophages	macrophage	NNS
cord-336510-qzm9wgde	386	13	from	from	IN
cord-336510-qzm9wgde	386	14	these	these	DT
cord-336510-qzm9wgde	386	15	mice	mouse	NNS
cord-336510-qzm9wgde	386	16	could	could	MD
cord-336510-qzm9wgde	386	17	be	be	VB
cord-336510-qzm9wgde	386	18	of	of	IN
cord-336510-qzm9wgde	386	19	interest	interest	NN
cord-336510-qzm9wgde	386	20	.	.	.
cord-336510-qzm9wgde	387	1	Analysis	analysis	NN
cord-336510-qzm9wgde	387	2	of	of	IN
cord-336510-qzm9wgde	387	3	the	the	DT
cord-336510-qzm9wgde	387	4	levels	level	NNS
cord-336510-qzm9wgde	387	5	of	of	IN
cord-336510-qzm9wgde	387	6	the	the	DT
cord-336510-qzm9wgde	387	7	IFN	IFN	NNP
cord-336510-qzm9wgde	387	8	-	-	HYPH
cord-336510-qzm9wgde	387	9	induced	induce	VBN
cord-336510-qzm9wgde	387	10	enzyme	enzyme	NN
cord-336510-qzm9wgde	387	11	2'-5'-oligoadenylate	2'-5'-oligoadenylate	CD
cord-336510-qzm9wgde	387	12	synthetase	synthetase	NN
cord-336510-qzm9wgde	387	13	(	(	-LRB-
cord-336510-qzm9wgde	387	14	OAS	OAS	NNP
cord-336510-qzm9wgde	387	15	)	)	-RRB-
cord-336510-qzm9wgde	387	16	in	in	IN
cord-336510-qzm9wgde	387	17	uninfected	uninfected	JJ
cord-336510-qzm9wgde	387	18	cells	cell	NNS
cord-336510-qzm9wgde	387	19	showed	show	VBD
cord-336510-qzm9wgde	387	20	low	low	JJ
cord-336510-qzm9wgde	387	21	but	but	CC
cord-336510-qzm9wgde	387	22	slightly	slightly	RB
cord-336510-qzm9wgde	387	23	higher	high	JJR
cord-336510-qzm9wgde	387	24	levels	level	NNS
cord-336510-qzm9wgde	387	25	in	in	IN
cord-336510-qzm9wgde	387	26	cells	cell	NNS
cord-336510-qzm9wgde	387	27	from	from	IN
cord-336510-qzm9wgde	387	28	relatively	relatively	RB
cord-336510-qzm9wgde	387	29	resistant	resistant	JJ
cord-336510-qzm9wgde	387	30	mice	mouse	NNS
cord-336510-qzm9wgde	387	31	[	[	-LRB-
cord-336510-qzm9wgde	387	32	322	322	CD
cord-336510-qzm9wgde	387	33	]	]	-RRB-
cord-336510-qzm9wgde	387	34	.	.	.
cord-336510-qzm9wgde	388	1	With	with	IN
cord-336510-qzm9wgde	388	2	LPS	LPS	NNP
cord-336510-qzm9wgde	388	3	,	,	,
cord-336510-qzm9wgde	388	4	cells	cell	NNS
cord-336510-qzm9wgde	388	5	from	from	IN
cord-336510-qzm9wgde	388	6	the	the	DT
cord-336510-qzm9wgde	388	7	relatively	relatively	RB
cord-336510-qzm9wgde	388	8	resistant	resistant	JJ
cord-336510-qzm9wgde	388	9	(	(	-LRB-
cord-336510-qzm9wgde	388	10	C57Bl/6	C57Bl/6	NNS
cord-336510-qzm9wgde	388	11	)	)	-RRB-
cord-336510-qzm9wgde	388	12	mice	mouse	NNS
cord-336510-qzm9wgde	388	13	show	show	VBP
cord-336510-qzm9wgde	388	14	an	an	DT
cord-336510-qzm9wgde	388	15	early	early	JJ
cord-336510-qzm9wgde	388	16	induction	induction	NN
cord-336510-qzm9wgde	388	17	pattern	pattern	NN
cord-336510-qzm9wgde	388	18	of	of	IN
cord-336510-qzm9wgde	388	19	IFN	IFN	NNP
cord-336510-qzm9wgde	388	20	-	-	HYPH
cord-336510-qzm9wgde	388	21	α	α	NNP
cord-336510-qzm9wgde	388	22	/	/	SYM
cord-336510-qzm9wgde	388	23	β	β	NN
cord-336510-qzm9wgde	388	24	,	,	,
cord-336510-qzm9wgde	388	25	peaking	peak	VBG
cord-336510-qzm9wgde	388	26	within	within	IN
cord-336510-qzm9wgde	388	27	2	2	CD
cord-336510-qzm9wgde	388	28	hours	hour	NNS
cord-336510-qzm9wgde	388	29	,	,	,
cord-336510-qzm9wgde	388	30	whereas	whereas	IN
cord-336510-qzm9wgde	388	31	cells	cell	NNS
cord-336510-qzm9wgde	388	32	from	from	IN
cord-336510-qzm9wgde	388	33	the	the	DT
cord-336510-qzm9wgde	388	34	susceptible	susceptible	JJ
cord-336510-qzm9wgde	388	35	BALB	BALB	NNP
cord-336510-qzm9wgde	388	36	/	/	SYM
cord-336510-qzm9wgde	388	37	c	c	NN
cord-336510-qzm9wgde	388	38	mice	mouse	NNS
cord-336510-qzm9wgde	388	39	demonstrate	demonstrate	VBP
cord-336510-qzm9wgde	388	40	a	a	DT
cord-336510-qzm9wgde	388	41	delayed	delay	VBN
cord-336510-qzm9wgde	388	42	response	response	NN
cord-336510-qzm9wgde	388	43	,	,	,
cord-336510-qzm9wgde	388	44	peaking	peak	VBG
cord-336510-qzm9wgde	388	45	7	7	CD
cord-336510-qzm9wgde	388	46	hours	hour	NNS
cord-336510-qzm9wgde	388	47	after	after	IN
cord-336510-qzm9wgde	388	48	induction	induction	NN
cord-336510-qzm9wgde	388	49	[	[	-LRB-
cord-336510-qzm9wgde	388	50	323	323	NN
cord-336510-qzm9wgde	388	51	]	]	-RRB-
cord-336510-qzm9wgde	388	52	.	.	.
cord-336510-qzm9wgde	389	1	Among	among	IN
cord-336510-qzm9wgde	389	2	other	other	JJ
cord-336510-qzm9wgde	389	3	transcription	transcription	NN
cord-336510-qzm9wgde	389	4	factors	factor	NNS
cord-336510-qzm9wgde	389	5	involved	involve	VBN
cord-336510-qzm9wgde	389	6	in	in	IN
cord-336510-qzm9wgde	389	7	induction	induction	NN
cord-336510-qzm9wgde	389	8	of	of	IN
cord-336510-qzm9wgde	389	9	the	the	DT
cord-336510-qzm9wgde	389	10	various	various	JJ
cord-336510-qzm9wgde	389	11	IFN	IFN	NNP
cord-336510-qzm9wgde	389	12	-	-	HYPH
cord-336510-qzm9wgde	389	13	α	α	NNP
cord-336510-qzm9wgde	389	14	/	/	SYM
cord-336510-qzm9wgde	389	15	β	β	NN
cord-336510-qzm9wgde	389	16	genes	gene	NNS
cord-336510-qzm9wgde	389	17	are	be	VBP
cord-336510-qzm9wgde	389	18	the	the	DT
cord-336510-qzm9wgde	389	19	heterodimeric	heterodimeric	JJ
cord-336510-qzm9wgde	389	20	NF	NF	NNP
cord-336510-qzm9wgde	389	21	-	-	HYPH
cord-336510-qzm9wgde	389	22	κB	κB	NNP
cord-336510-qzm9wgde	389	23	family	family	NN
cord-336510-qzm9wgde	389	24	,	,	,
cord-336510-qzm9wgde	389	25	which	which	WDT
cord-336510-qzm9wgde	389	26	is	be	VBZ
cord-336510-qzm9wgde	389	27	activated	activate	VBN
cord-336510-qzm9wgde	389	28	by	by	IN
cord-336510-qzm9wgde	389	29	TLRs	tlr	NNS
cord-336510-qzm9wgde	389	30	,	,	,
cord-336510-qzm9wgde	389	31	IL-1R	IL-1R	NNP
cord-336510-qzm9wgde	389	32	,	,	,
cord-336510-qzm9wgde	389	33	and	and	CC
cord-336510-qzm9wgde	389	34	TNFR	TNFR	NNP
cord-336510-qzm9wgde	389	35	[	[	-LRB-
cord-336510-qzm9wgde	389	36	324	324	CD
cord-336510-qzm9wgde	389	37	]	]	-RRB-
cord-336510-qzm9wgde	389	38	.	.	.
cord-336510-qzm9wgde	390	1	During	during	IN
cord-336510-qzm9wgde	390	2	a	a	DT
cord-336510-qzm9wgde	390	3	HSV	HSV	NNP
cord-336510-qzm9wgde	390	4	infection	infection	NN
cord-336510-qzm9wgde	390	5	NF	nf	NN
cord-336510-qzm9wgde	390	6	-	-	HYPH
cord-336510-qzm9wgde	390	7	κB	κB	NNP
cord-336510-qzm9wgde	390	8	is	be	VBZ
cord-336510-qzm9wgde	390	9	activated	activate	VBN
cord-336510-qzm9wgde	390	10	and	and	CC
cord-336510-qzm9wgde	390	11	translocated	translocate	VBN
cord-336510-qzm9wgde	390	12	to	to	IN
cord-336510-qzm9wgde	390	13	the	the	DT
cord-336510-qzm9wgde	390	14	nucleus	nucleus	NN
cord-336510-qzm9wgde	390	15	[	[	-LRB-
cord-336510-qzm9wgde	390	16	325	325	CD
cord-336510-qzm9wgde	390	17	]	]	-RRB-
cord-336510-qzm9wgde	390	18	.	.	.
cord-336510-qzm9wgde	391	1	Many	many	JJ
cord-336510-qzm9wgde	391	2	regulatory	regulatory	JJ
cord-336510-qzm9wgde	391	3	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	391	4	of	of	IN
cord-336510-qzm9wgde	391	5	NF	nf	NN
cord-336510-qzm9wgde	391	6	-	-	HYPH
cord-336510-qzm9wgde	391	7	κB	κb	CD
cord-336510-qzm9wgde	391	8	activation	activation	NN
cord-336510-qzm9wgde	391	9	exist	exist	VBP
cord-336510-qzm9wgde	391	10	,	,	,
cord-336510-qzm9wgde	391	11	one	one	CD
cord-336510-qzm9wgde	391	12	of	of	IN
cord-336510-qzm9wgde	391	13	them	-PRON-	PRP
cord-336510-qzm9wgde	391	14	exerted	exert	VBD
cord-336510-qzm9wgde	391	15	through	through	IN
cord-336510-qzm9wgde	391	16	TNF	TNF	NNP
cord-336510-qzm9wgde	391	17	,	,	,
cord-336510-qzm9wgde	391	18	which	which	WDT
cord-336510-qzm9wgde	391	19	is	be	VBZ
cord-336510-qzm9wgde	391	20	produced	produce	VBN
cord-336510-qzm9wgde	391	21	by	by	IN
cord-336510-qzm9wgde	391	22	macrophages	macrophage	NNS
cord-336510-qzm9wgde	391	23	very	very	RB
cord-336510-qzm9wgde	391	24	early	early	RB
cord-336510-qzm9wgde	391	25	during	during	IN
cord-336510-qzm9wgde	391	26	HSV	HSV	NNP
cord-336510-qzm9wgde	391	27	infection	infection	NN
cord-336510-qzm9wgde	391	28	(	(	-LRB-
cord-336510-qzm9wgde	391	29	fig	fig	NN
cord-336510-qzm9wgde	391	30	.	.	NNP
cord-336510-qzm9wgde	391	31	2	2	LS
cord-336510-qzm9wgde	391	32	)	)	-RRB-
cord-336510-qzm9wgde	392	1	[	[	-LRB-
cord-336510-qzm9wgde	392	2	293	293	CD
cord-336510-qzm9wgde	392	3	,	,	,
cord-336510-qzm9wgde	392	4	300	300	CD
cord-336510-qzm9wgde	392	5	,	,	,
cord-336510-qzm9wgde	392	6	325	325	CD
cord-336510-qzm9wgde	392	7	,	,	,
cord-336510-qzm9wgde	392	8	326	326	CD
cord-336510-qzm9wgde	392	9	]	]	-RRB-
cord-336510-qzm9wgde	392	10	.	.	.
cord-336510-qzm9wgde	393	1	Thus	thus	RB
cord-336510-qzm9wgde	393	2	,	,	,
cord-336510-qzm9wgde	393	3	the	the	DT
cord-336510-qzm9wgde	393	4	responsible	responsible	JJ
cord-336510-qzm9wgde	393	5	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	393	6	might	may	MD
cord-336510-qzm9wgde	393	7	be	be	VB
cord-336510-qzm9wgde	393	8	exerted	exert	VBN
cord-336510-qzm9wgde	393	9	by	by	IN
cord-336510-qzm9wgde	393	10	other	other	JJ
cord-336510-qzm9wgde	393	11	regulatory	regulatory	JJ
cord-336510-qzm9wgde	393	12	signals	signal	NNS
cord-336510-qzm9wgde	393	13	,	,	,
cord-336510-qzm9wgde	393	14	influencing	influence	VBG
cord-336510-qzm9wgde	393	15	the	the	DT
cord-336510-qzm9wgde	393	16	magnitude	magnitude	NN
cord-336510-qzm9wgde	393	17	of	of	IN
cord-336510-qzm9wgde	393	18	the	the	DT
cord-336510-qzm9wgde	393	19	HSV	HSV	NNP
cord-336510-qzm9wgde	393	20	-	-	HYPH
cord-336510-qzm9wgde	393	21	triggered	trigger	VBN
cord-336510-qzm9wgde	393	22	IFN	IFN	NNP
cord-336510-qzm9wgde	393	23	-	-	HYPH
cord-336510-qzm9wgde	393	24	α	α	NNP
cord-336510-qzm9wgde	393	25	/	/	SYM
cord-336510-qzm9wgde	393	26	β	β	NN
cord-336510-qzm9wgde	393	27	induction	induction	NN
cord-336510-qzm9wgde	393	28	pathway	pathway	NN
cord-336510-qzm9wgde	393	29	,	,	,
cord-336510-qzm9wgde	393	30	and	and	CC
cord-336510-qzm9wgde	393	31	perhaps	perhaps	RB
cord-336510-qzm9wgde	393	32	not	not	RB
cord-336510-qzm9wgde	393	33	by	by	IN
cord-336510-qzm9wgde	393	34	this	this	DT
cord-336510-qzm9wgde	393	35	pathway	pathway	NN
cord-336510-qzm9wgde	393	36	in	in	IN
cord-336510-qzm9wgde	393	37	itself	-PRON-	PRP
cord-336510-qzm9wgde	393	38	[	[	-LRB-
cord-336510-qzm9wgde	393	39	327	327	CD
cord-336510-qzm9wgde	393	40	]	]	-RRB-
cord-336510-qzm9wgde	393	41	.	.	.
cord-336510-qzm9wgde	394	1	A	a	DT
cord-336510-qzm9wgde	394	2	number	number	NN
cord-336510-qzm9wgde	394	3	of	of	IN
cord-336510-qzm9wgde	394	4	X	x	NN
cord-336510-qzm9wgde	394	5	-	-	HYPH
cord-336510-qzm9wgde	394	6	linked	link	VBN
cord-336510-qzm9wgde	394	7	immunodeficiencies	immunodeficiency	NNS
cord-336510-qzm9wgde	394	8	have	have	VBP
cord-336510-qzm9wgde	394	9	been	be	VBN
cord-336510-qzm9wgde	394	10	described	describe	VBN
cord-336510-qzm9wgde	394	11	,	,	,
cord-336510-qzm9wgde	394	12	one	one	CD
cord-336510-qzm9wgde	394	13	of	of	IN
cord-336510-qzm9wgde	394	14	them	-PRON-	PRP
cord-336510-qzm9wgde	394	15	being	be	VBG
cord-336510-qzm9wgde	394	16	the	the	DT
cord-336510-qzm9wgde	394	17	Wiskott	Wiskott	NNP
cord-336510-qzm9wgde	394	18	-	-	HYPH
cord-336510-qzm9wgde	394	19	Aldrich	Aldrich	NNP
cord-336510-qzm9wgde	394	20	syndrome	syndrome	NN
cord-336510-qzm9wgde	394	21	with	with	IN
cord-336510-qzm9wgde	394	22	defects	defect	NNS
cord-336510-qzm9wgde	394	23	in	in	IN
cord-336510-qzm9wgde	394	24	a	a	DT
cord-336510-qzm9wgde	394	25	protein	protein	NN
cord-336510-qzm9wgde	394	26	expressed	express	VBN
cord-336510-qzm9wgde	394	27	in	in	IN
cord-336510-qzm9wgde	394	28	haematopoietic	haematopoietic	JJ
cord-336510-qzm9wgde	394	29	cells	cell	NNS
cord-336510-qzm9wgde	394	30	,	,	,
cord-336510-qzm9wgde	394	31	facilitating	facilitate	VBG
cord-336510-qzm9wgde	394	32	reorganization	reorganization	NN
cord-336510-qzm9wgde	394	33	of	of	IN
cord-336510-qzm9wgde	394	34	the	the	DT
cord-336510-qzm9wgde	394	35	actin	actin	NN
cord-336510-qzm9wgde	394	36	cytoskeleton	cytoskeleton	NN
cord-336510-qzm9wgde	394	37	,	,	,
cord-336510-qzm9wgde	394	38	and	and	CC
cord-336510-qzm9wgde	394	39	thus	thus	RB
cord-336510-qzm9wgde	394	40	influencing	influence	VBG
cord-336510-qzm9wgde	394	41	the	the	DT
cord-336510-qzm9wgde	394	42	mobility	mobility	NN
cord-336510-qzm9wgde	394	43	of	of	IN
cord-336510-qzm9wgde	394	44	immune	immune	JJ
cord-336510-qzm9wgde	394	45	cells	cell	NNS
cord-336510-qzm9wgde	394	46	and	and	CC
cord-336510-qzm9wgde	394	47	chemotaxis	chemotaxis	NN
cord-336510-qzm9wgde	394	48	of	of	IN
cord-336510-qzm9wgde	394	49	macrophages	macrophage	NNS
cord-336510-qzm9wgde	394	50	.	.	.
cord-336510-qzm9wgde	395	1	Patients	patient	NNS
cord-336510-qzm9wgde	395	2	with	with	IN
cord-336510-qzm9wgde	395	3	this	this	DT
cord-336510-qzm9wgde	395	4	X	x	NN
cord-336510-qzm9wgde	395	5	-	-	HYPH
cord-336510-qzm9wgde	395	6	linked	link	VBN
cord-336510-qzm9wgde	395	7	immunodeficiency	immunodeficiency	NN
cord-336510-qzm9wgde	395	8	show	show	NN
cord-336510-qzm9wgde	395	9	aggravated	aggravate	VBD
cord-336510-qzm9wgde	395	10	herpetic	herpetic	JJ
cord-336510-qzm9wgde	395	11	infections	infection	NNS
cord-336510-qzm9wgde	395	12	,	,	,
cord-336510-qzm9wgde	395	13	and	and	CC
cord-336510-qzm9wgde	395	14	cells	cell	NNS
cord-336510-qzm9wgde	395	15	from	from	IN
cord-336510-qzm9wgde	395	16	some	some	DT
cord-336510-qzm9wgde	395	17	patients	patient	NNS
cord-336510-qzm9wgde	395	18	seem	seem	VBP
cord-336510-qzm9wgde	395	19	to	to	TO
cord-336510-qzm9wgde	395	20	produce	produce	VB
cord-336510-qzm9wgde	395	21	lower	low	JJR
cord-336510-qzm9wgde	395	22	amounts	amount	NNS
cord-336510-qzm9wgde	395	23	of	of	IN
cord-336510-qzm9wgde	395	24	IFN	IFN	NNP
cord-336510-qzm9wgde	395	25	in	in	IN
cord-336510-qzm9wgde	395	26	response	response	NN
cord-336510-qzm9wgde	395	27	to	to	IN
cord-336510-qzm9wgde	395	28	HSV	HSV	NNP
cord-336510-qzm9wgde	395	29	[	[	-LRB-
cord-336510-qzm9wgde	395	30	328	328	CD
cord-336510-qzm9wgde	395	31	]	]	-RRB-
cord-336510-qzm9wgde	395	32	[	[	-LRB-
cord-336510-qzm9wgde	395	33	329	329	CD
cord-336510-qzm9wgde	395	34	]	]	-RRB-
cord-336510-qzm9wgde	395	35	[	[	-LRB-
cord-336510-qzm9wgde	395	36	330	330	CD
cord-336510-qzm9wgde	395	37	]	]	-RRB-
cord-336510-qzm9wgde	395	38	.	.	.
cord-336510-qzm9wgde	396	1	Cells	cell	NNS
cord-336510-qzm9wgde	396	2	from	from	IN
cord-336510-qzm9wgde	396	3	patients	patient	NNS
cord-336510-qzm9wgde	396	4	with	with	IN
cord-336510-qzm9wgde	396	5	another	another	DT
cord-336510-qzm9wgde	396	6	X	x	NN
cord-336510-qzm9wgde	396	7	-	-	HYPH
cord-336510-qzm9wgde	396	8	linked	link	VBN
cord-336510-qzm9wgde	396	9	immunodeficiency	immunodeficiency	NN
cord-336510-qzm9wgde	396	10	with	with	IN
cord-336510-qzm9wgde	396	11	mutations	mutation	NNS
cord-336510-qzm9wgde	396	12	in	in	IN
cord-336510-qzm9wgde	396	13	the	the	DT
cord-336510-qzm9wgde	396	14	CD40-ligand	CD40-ligand	NNP
cord-336510-qzm9wgde	396	15	,	,	,
cord-336510-qzm9wgde	396	16	a	a	DT
cord-336510-qzm9wgde	396	17	member	member	NN
cord-336510-qzm9wgde	396	18	of	of	IN
cord-336510-qzm9wgde	396	19	the	the	DT
cord-336510-qzm9wgde	396	20	TNF	TNF	NNP
cord-336510-qzm9wgde	396	21	family	family	NN
cord-336510-qzm9wgde	396	22	,	,	,
cord-336510-qzm9wgde	396	23	showed	show	VBD
cord-336510-qzm9wgde	396	24	decreased	decrease	VBD
cord-336510-qzm9wgde	396	25	IFN	IFN	NNP
cord-336510-qzm9wgde	396	26	-	-	HYPH
cord-336510-qzm9wgde	396	27	α	α	NNP
cord-336510-qzm9wgde	396	28	/	/	SYM
cord-336510-qzm9wgde	396	29	β	β	NN
cord-336510-qzm9wgde	396	30	production	production	NN
cord-336510-qzm9wgde	396	31	when	when	WRB
cord-336510-qzm9wgde	396	32	infected	infect	VBN
cord-336510-qzm9wgde	396	33	with	with	IN
cord-336510-qzm9wgde	396	34	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	396	35	,	,	,
cord-336510-qzm9wgde	396	36	but	but	CC
cord-336510-qzm9wgde	396	37	these	these	DT
cord-336510-qzm9wgde	396	38	patients	patient	NNS
cord-336510-qzm9wgde	396	39	apparently	apparently	RB
cord-336510-qzm9wgde	396	40	show	show	VBP
cord-336510-qzm9wgde	396	41	a	a	DT
cord-336510-qzm9wgde	396	42	normal	normal	JJ
cord-336510-qzm9wgde	396	43	response	response	NN
cord-336510-qzm9wgde	396	44	to	to	IN
cord-336510-qzm9wgde	396	45	viral	viral	JJ
cord-336510-qzm9wgde	396	46	infections	infection	NNS
cord-336510-qzm9wgde	396	47	[	[	-LRB-
cord-336510-qzm9wgde	396	48	331	331	CD
cord-336510-qzm9wgde	396	49	,	,	,
cord-336510-qzm9wgde	396	50	332	332	CD
cord-336510-qzm9wgde	396	51	]	]	-RRB-
cord-336510-qzm9wgde	396	52	.	.	.
cord-336510-qzm9wgde	397	1	This	this	DT
cord-336510-qzm9wgde	397	2	supports	support	VBZ
cord-336510-qzm9wgde	397	3	the	the	DT
cord-336510-qzm9wgde	397	4	notion	notion	NN
cord-336510-qzm9wgde	397	5	above	above	IN
cord-336510-qzm9wgde	397	6	that	that	DT
cord-336510-qzm9wgde	397	7	other	other	JJ
cord-336510-qzm9wgde	397	8	regulatory	regulatory	JJ
cord-336510-qzm9wgde	397	9	signals	signal	NNS
cord-336510-qzm9wgde	397	10	might	may	MD
cord-336510-qzm9wgde	397	11	be	be	VB
cord-336510-qzm9wgde	397	12	involved	involve	VBN
cord-336510-qzm9wgde	397	13	.	.	.
cord-336510-qzm9wgde	398	1	The	the	DT
cord-336510-qzm9wgde	398	2	overall	overall	JJ
cord-336510-qzm9wgde	398	3	effects	effect	NNS
cord-336510-qzm9wgde	398	4	of	of	IN
cord-336510-qzm9wgde	398	5	the	the	DT
cord-336510-qzm9wgde	398	6	IFN	IFN	NNP
cord-336510-qzm9wgde	398	7	-	-	HYPH
cord-336510-qzm9wgde	398	8	α	α	NNP
cord-336510-qzm9wgde	398	9	/	/	SYM
cord-336510-qzm9wgde	398	10	β	β	NN
cord-336510-qzm9wgde	398	11	system	system	NN
cord-336510-qzm9wgde	398	12	,	,	,
cord-336510-qzm9wgde	398	13	besides	besides	IN
cord-336510-qzm9wgde	398	14	the	the	DT
cord-336510-qzm9wgde	398	15	production	production	NN
cord-336510-qzm9wgde	398	16	as	as	IN
cord-336510-qzm9wgde	398	17	described	describe	VBN
cord-336510-qzm9wgde	398	18	above	above	RB
cord-336510-qzm9wgde	398	19	,	,	,
cord-336510-qzm9wgde	398	20	are	be	VBP
cord-336510-qzm9wgde	398	21	determined	determine	VBN
cord-336510-qzm9wgde	398	22	by	by	IN
cord-336510-qzm9wgde	398	23	the	the	DT
cord-336510-qzm9wgde	398	24	sensitivity	sensitivity	NN
cord-336510-qzm9wgde	398	25	of	of	IN
cord-336510-qzm9wgde	398	26	cells	cell	NNS
cord-336510-qzm9wgde	398	27	to	to	IN
cord-336510-qzm9wgde	398	28	the	the	DT
cord-336510-qzm9wgde	398	29	secreted	secrete	VBN
cord-336510-qzm9wgde	398	30	IFN	IFN	NNP
cord-336510-qzm9wgde	398	31	-	-	HYPH
cord-336510-qzm9wgde	398	32	α	α	NNP
cord-336510-qzm9wgde	398	33	/	/	SYM
cord-336510-qzm9wgde	398	34	β	β	NN
cord-336510-qzm9wgde	398	35	.	.	.
cord-336510-qzm9wgde	399	1	The	the	DT
cord-336510-qzm9wgde	399	2	effector	effector	NN
cord-336510-qzm9wgde	399	3	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	399	4	of	of	IN
cord-336510-qzm9wgde	399	5	IFN	IFN	NNP
cord-336510-qzm9wgde	399	6	-	-	HYPH
cord-336510-qzm9wgde	399	7	α	α	NNP
cord-336510-qzm9wgde	399	8	/	/	SYM
cord-336510-qzm9wgde	399	9	β	β	NN
cord-336510-qzm9wgde	399	10	on	on	IN
cord-336510-qzm9wgde	399	11	HSV	HSV	NNP
cord-336510-qzm9wgde	399	12	replication	replication	NN
cord-336510-qzm9wgde	399	13	are	be	VBP
cord-336510-qzm9wgde	399	14	not	not	RB
cord-336510-qzm9wgde	399	15	fully	fully	RB
cord-336510-qzm9wgde	399	16	elucidated	elucidate	VBN
cord-336510-qzm9wgde	399	17	.	.	.
cord-336510-qzm9wgde	400	1	Several	several	JJ
cord-336510-qzm9wgde	400	2	IFN	IFN	NNP
cord-336510-qzm9wgde	400	3	-	-	HYPH
cord-336510-qzm9wgde	400	4	α	α	NNP
cord-336510-qzm9wgde	400	5	/	/	SYM
cord-336510-qzm9wgde	400	6	β	β	NN
cord-336510-qzm9wgde	400	7	-	-	HYPH
cord-336510-qzm9wgde	400	8	activated	activate	VBN
cord-336510-qzm9wgde	400	9	systems	system	NNS
cord-336510-qzm9wgde	400	10	are	be	VBP
cord-336510-qzm9wgde	400	11	involved	involve	VBN
cord-336510-qzm9wgde	400	12	,	,	,
cord-336510-qzm9wgde	400	13	including	include	VBG
cord-336510-qzm9wgde	400	14	the	the	DT
cord-336510-qzm9wgde	400	15	dsRNA	dsrna	NN
cord-336510-qzm9wgde	400	16	-	-	HYPH
cord-336510-qzm9wgde	400	17	activated	activate	VBN
cord-336510-qzm9wgde	400	18	PKR	PKR	NNP
cord-336510-qzm9wgde	400	19	,	,	,
cord-336510-qzm9wgde	400	20	which	which	WDT
cord-336510-qzm9wgde	400	21	phosphorylates	phosphorylate	VBZ
cord-336510-qzm9wgde	400	22	,	,	,
cord-336510-qzm9wgde	400	23	and	and	CC
cord-336510-qzm9wgde	400	24	thereby	thereby	RB
cord-336510-qzm9wgde	400	25	inhibits	inhibit	VBZ
cord-336510-qzm9wgde	400	26	,	,	,
cord-336510-qzm9wgde	400	27	the	the	DT
cord-336510-qzm9wgde	400	28	elongation	elongation	NN
cord-336510-qzm9wgde	400	29	initiation	initiation	NN
cord-336510-qzm9wgde	400	30	factor	factor	NN
cord-336510-qzm9wgde	400	31	(	(	-LRB-
cord-336510-qzm9wgde	400	32	eIF)-2α	eif)-2α	CD
cord-336510-qzm9wgde	400	33	,	,	,
cord-336510-qzm9wgde	400	34	resulting	result	VBG
cord-336510-qzm9wgde	400	35	in	in	IN
cord-336510-qzm9wgde	400	36	inhibition	inhibition	NN
cord-336510-qzm9wgde	400	37	of	of	IN
cord-336510-qzm9wgde	400	38	translation	translation	NN
cord-336510-qzm9wgde	400	39	[	[	-LRB-
cord-336510-qzm9wgde	400	40	333	333	CD
cord-336510-qzm9wgde	400	41	]	]	-RRB-
cord-336510-qzm9wgde	400	42	.	.	.
cord-336510-qzm9wgde	401	1	Another	another	DT
cord-336510-qzm9wgde	401	2	important	important	JJ
cord-336510-qzm9wgde	401	3	mediator	mediator	NN
cord-336510-qzm9wgde	401	4	of	of	IN
cord-336510-qzm9wgde	401	5	the	the	DT
cord-336510-qzm9wgde	401	6	antiviral	antiviral	JJ
cord-336510-qzm9wgde	401	7	activity	activity	NN
cord-336510-qzm9wgde	401	8	is	be	VBZ
cord-336510-qzm9wgde	401	9	the	the	DT
cord-336510-qzm9wgde	401	10	OAS	OAS	NNP
cord-336510-qzm9wgde	401	11	system	system	NN
cord-336510-qzm9wgde	401	12	,	,	,
cord-336510-qzm9wgde	401	13	which	which	WDT
cord-336510-qzm9wgde	401	14	activates	activate	VBZ
cord-336510-qzm9wgde	401	15	2'-5'oligoadenylate	2'-5'oligoadenylate	CD
cord-336510-qzm9wgde	401	16	-	-	HYPH
cord-336510-qzm9wgde	401	17	dependent	dependent	JJ
cord-336510-qzm9wgde	401	18	RNase	rnase	NN
cord-336510-qzm9wgde	401	19	L	l	NN
cord-336510-qzm9wgde	401	20	with	with	IN
cord-336510-qzm9wgde	401	21	the	the	DT
cord-336510-qzm9wgde	401	22	capacity	capacity	NN
cord-336510-qzm9wgde	401	23	to	to	TO
cord-336510-qzm9wgde	401	24	degrade	degrade	VB
cord-336510-qzm9wgde	401	25	single	single	RB
cord-336510-qzm9wgde	401	26	-	-	HYPH
cord-336510-qzm9wgde	401	27	stranded	strand	VBN
cord-336510-qzm9wgde	401	28	RNA	RNA	NNP
cord-336510-qzm9wgde	401	29	[	[	-LRB-
cord-336510-qzm9wgde	401	30	333	333	CD
cord-336510-qzm9wgde	401	31	]	]	-RRB-
cord-336510-qzm9wgde	401	32	.	.	.
cord-336510-qzm9wgde	402	1	Lately	lately	RB
cord-336510-qzm9wgde	402	2	,	,	,
cord-336510-qzm9wgde	402	3	the	the	DT
cord-336510-qzm9wgde	402	4	PML	PML	NNP
cord-336510-qzm9wgde	402	5	bodies	body	NNS
cord-336510-qzm9wgde	402	6	have	have	VBP
cord-336510-qzm9wgde	402	7	been	be	VBN
cord-336510-qzm9wgde	402	8	described	describe	VBN
cord-336510-qzm9wgde	402	9	as	as	IN
cord-336510-qzm9wgde	402	10	crucial	crucial	JJ
cord-336510-qzm9wgde	402	11	for	for	IN
cord-336510-qzm9wgde	402	12	the	the	DT
cord-336510-qzm9wgde	402	13	anti	anti	JJ
cord-336510-qzm9wgde	402	14	-	-	JJ
cord-336510-qzm9wgde	402	15	HSV	hsv	JJ
cord-336510-qzm9wgde	402	16	effect	effect	NN
cord-336510-qzm9wgde	402	17	of	of	IN
cord-336510-qzm9wgde	402	18	IFN	IFN	NNP
cord-336510-qzm9wgde	402	19	-	-	HYPH
cord-336510-qzm9wgde	402	20	α/	α/	NNP
cord-336510-qzm9wgde	402	21	β	β	NN
cord-336510-qzm9wgde	402	22	[	[	-LRB-
cord-336510-qzm9wgde	402	23	334	334	CD
cord-336510-qzm9wgde	402	24	]	]	-RRB-
cord-336510-qzm9wgde	402	25	.	.	.
cord-336510-qzm9wgde	403	1	In	in	IN
cord-336510-qzm9wgde	403	2	mice	mouse	NNS
cord-336510-qzm9wgde	403	3	exhibiting	exhibit	VBG
cord-336510-qzm9wgde	403	4	a	a	DT
cord-336510-qzm9wgde	403	5	relatively	relatively	RB
cord-336510-qzm9wgde	403	6	HSV	hsv	JJ
cord-336510-qzm9wgde	403	7	-	-	HYPH
cord-336510-qzm9wgde	403	8	resistant	resistant	JJ
cord-336510-qzm9wgde	403	9	phenotype	phenotype	NN
cord-336510-qzm9wgde	403	10	,	,	,
cord-336510-qzm9wgde	403	11	the	the	DT
cord-336510-qzm9wgde	403	12	direct	direct	JJ
cord-336510-qzm9wgde	403	13	antiviral	antiviral	JJ
cord-336510-qzm9wgde	403	14	effect	effect	NN
cord-336510-qzm9wgde	403	15	of	of	IN
cord-336510-qzm9wgde	403	16	IFN	IFN	NNP
cord-336510-qzm9wgde	403	17	-	-	HYPH
cord-336510-qzm9wgde	403	18	α	α	NNP
cord-336510-qzm9wgde	403	19	/	/	SYM
cord-336510-qzm9wgde	403	20	β	β	NN
cord-336510-qzm9wgde	403	21	in	in	IN
cord-336510-qzm9wgde	403	22	embryonic	embryonic	JJ
cord-336510-qzm9wgde	403	23	cells	cell	NNS
cord-336510-qzm9wgde	403	24	was	be	VBD
cord-336510-qzm9wgde	403	25	found	find	VBN
cord-336510-qzm9wgde	403	26	to	to	TO
cord-336510-qzm9wgde	403	27	be	be	VB
cord-336510-qzm9wgde	403	28	approximately	approximately	RB
cord-336510-qzm9wgde	403	29	three	three	CD
cord-336510-qzm9wgde	403	30	-	-	HYPH
cord-336510-qzm9wgde	403	31	fold	fold	VB
cord-336510-qzm9wgde	403	32	higher	higher	RBR
cord-336510-qzm9wgde	403	33	than	than	IN
cord-336510-qzm9wgde	403	34	in	in	IN
cord-336510-qzm9wgde	403	35	cells	cell	NNS
cord-336510-qzm9wgde	403	36	from	from	IN
cord-336510-qzm9wgde	403	37	susceptible	susceptible	JJ
cord-336510-qzm9wgde	403	38	mice	mouse	NNS
cord-336510-qzm9wgde	403	39	[	[	-LRB-
cord-336510-qzm9wgde	403	40	322	322	CD
cord-336510-qzm9wgde	403	41	]	]	-RRB-
cord-336510-qzm9wgde	403	42	.	.	.
cord-336510-qzm9wgde	404	1	Data	datum	NNS
cord-336510-qzm9wgde	404	2	from	from	IN
cord-336510-qzm9wgde	404	3	another	another	DT
cord-336510-qzm9wgde	404	4	study	study	NN
cord-336510-qzm9wgde	404	5	showed	show	VBD
cord-336510-qzm9wgde	404	6	comparable	comparable	JJ
cord-336510-qzm9wgde	404	7	results	result	NNS
cord-336510-qzm9wgde	404	8	on	on	IN
cord-336510-qzm9wgde	404	9	IFN	IFN	NNP
cord-336510-qzm9wgde	404	10	-	-	HYPH
cord-336510-qzm9wgde	404	11	α	α	NNP
cord-336510-qzm9wgde	404	12	/	/	SYM
cord-336510-qzm9wgde	404	13	β	β	NN
cord-336510-qzm9wgde	404	14	sensitivity	sensitivity	NN
cord-336510-qzm9wgde	404	15	concerning	concern	VBG
cord-336510-qzm9wgde	404	16	the	the	DT
cord-336510-qzm9wgde	404	17	replication	replication	NN
cord-336510-qzm9wgde	404	18	of	of	IN
cord-336510-qzm9wgde	404	19	encephalomyocarditis	encephalomyocarditis	NNP
cord-336510-qzm9wgde	404	20	virus	virus	NN
cord-336510-qzm9wgde	404	21	(	(	-LRB-
cord-336510-qzm9wgde	404	22	EMCV	EMCV	NNP
cord-336510-qzm9wgde	404	23	)	)	-RRB-
cord-336510-qzm9wgde	404	24	in	in	IN
cord-336510-qzm9wgde	404	25	cells	cell	NNS
cord-336510-qzm9wgde	404	26	from	from	IN
cord-336510-qzm9wgde	404	27	the	the	DT
cord-336510-qzm9wgde	404	28	same	same	JJ
cord-336510-qzm9wgde	404	29	mouse	mouse	NN
cord-336510-qzm9wgde	404	30	strains	strain	NNS
cord-336510-qzm9wgde	404	31	[	[	-LRB-
cord-336510-qzm9wgde	404	32	335	335	CD
cord-336510-qzm9wgde	404	33	]	]	-RRB-
cord-336510-qzm9wgde	404	34	.	.	.
cord-336510-qzm9wgde	405	1	This	this	DT
cord-336510-qzm9wgde	405	2	phenomenon	phenomenon	NN
cord-336510-qzm9wgde	405	3	was	be	VBD
cord-336510-qzm9wgde	405	4	inherited	inherit	VBN
cord-336510-qzm9wgde	405	5	as	as	IN
cord-336510-qzm9wgde	405	6	a	a	DT
cord-336510-qzm9wgde	405	7	co	co	JJ
cord-336510-qzm9wgde	405	8	-	-	JJ
cord-336510-qzm9wgde	405	9	dominant	dominant	JJ
cord-336510-qzm9wgde	405	10	autosomal	autosomal	JJ
cord-336510-qzm9wgde	405	11	trait	trait	NN
cord-336510-qzm9wgde	405	12	without	without	IN
cord-336510-qzm9wgde	405	13	any	any	DT
cord-336510-qzm9wgde	405	14	apparent	apparent	JJ
cord-336510-qzm9wgde	405	15	influence	influence	NN
cord-336510-qzm9wgde	405	16	of	of	IN
cord-336510-qzm9wgde	405	17	X	x	NN
cord-336510-qzm9wgde	405	18	-	-	HYPH
cord-336510-qzm9wgde	405	19	linked	link	VBN
cord-336510-qzm9wgde	405	20	genes	gene	NNS
cord-336510-qzm9wgde	405	21	[	[	-LRB-
cord-336510-qzm9wgde	405	22	322	322	CD
cord-336510-qzm9wgde	405	23	,	,	,
cord-336510-qzm9wgde	405	24	336	336	CD
cord-336510-qzm9wgde	405	25	]	]	-RRB-
cord-336510-qzm9wgde	405	26	.	.	.
cord-336510-qzm9wgde	406	1	Further	further	JJ
cord-336510-qzm9wgde	406	2	studies	study	NNS
cord-336510-qzm9wgde	406	3	in	in	IN
cord-336510-qzm9wgde	406	4	mouse	mouse	NN
cord-336510-qzm9wgde	406	5	fibroblasts	fibroblast	NNS
cord-336510-qzm9wgde	406	6	have	have	VBP
cord-336510-qzm9wgde	406	7	revealed	reveal	VBN
cord-336510-qzm9wgde	406	8	that	that	IN
cord-336510-qzm9wgde	406	9	TNF	TNF	NNP
cord-336510-qzm9wgde	406	10	intensify	intensify	VB
cord-336510-qzm9wgde	406	11	the	the	DT
cord-336510-qzm9wgde	406	12	antiviral	antiviral	JJ
cord-336510-qzm9wgde	406	13	effect	effect	NN
cord-336510-qzm9wgde	406	14	of	of	IN
cord-336510-qzm9wgde	406	15	IFN	IFN	NNP
cord-336510-qzm9wgde	406	16	-	-	HYPH
cord-336510-qzm9wgde	406	17	α	α	NNP
cord-336510-qzm9wgde	406	18	/	/	SYM
cord-336510-qzm9wgde	406	19	β	β	NN
cord-336510-qzm9wgde	406	20	and	and	CC
cord-336510-qzm9wgde	406	21	,	,	,
cord-336510-qzm9wgde	406	22	thus	thus	RB
cord-336510-qzm9wgde	406	23	,	,	,
cord-336510-qzm9wgde	406	24	the	the	DT
cord-336510-qzm9wgde	406	25	in	in	IN
cord-336510-qzm9wgde	406	26	vivo	vivo	NN
cord-336510-qzm9wgde	406	27	situation	situation	NN
cord-336510-qzm9wgde	406	28	seems	seem	VBZ
cord-336510-qzm9wgde	406	29	more	more	RBR
cord-336510-qzm9wgde	406	30	complicated	complicated	JJ
cord-336510-qzm9wgde	406	31	(	(	-LRB-
cord-336510-qzm9wgde	406	32	fig	fig	NN
cord-336510-qzm9wgde	406	33	.	.	NNP
cord-336510-qzm9wgde	406	34	2	2	LS
cord-336510-qzm9wgde	406	35	)	)	-RRB-
cord-336510-qzm9wgde	407	1	[	[	-LRB-
cord-336510-qzm9wgde	407	2	300	300	CD
cord-336510-qzm9wgde	407	3	,	,	,
cord-336510-qzm9wgde	407	4	337	337	CD
cord-336510-qzm9wgde	407	5	]	]	-RRB-
cord-336510-qzm9wgde	407	6	.	.	.
cord-336510-qzm9wgde	408	1	In	in	IN
cord-336510-qzm9wgde	408	2	the	the	DT
cord-336510-qzm9wgde	408	3	original	original	JJ
cord-336510-qzm9wgde	408	4	publication	publication	NN
cord-336510-qzm9wgde	408	5	on	on	IN
cord-336510-qzm9wgde	408	6	genetics	genetic	NNS
cord-336510-qzm9wgde	408	7	of	of	IN
cord-336510-qzm9wgde	408	8	HSV	HSV	NNP
cord-336510-qzm9wgde	408	9	susceptibility	susceptibility	NN
cord-336510-qzm9wgde	408	10	in	in	IN
cord-336510-qzm9wgde	408	11	inbred	inbred	JJ
cord-336510-qzm9wgde	408	12	mice	mouse	NNS
cord-336510-qzm9wgde	408	13	,	,	,
cord-336510-qzm9wgde	408	14	Lopez	Lopez	NNP
cord-336510-qzm9wgde	408	15	reported	report	VBD
cord-336510-qzm9wgde	408	16	fibroblasts	fibroblast	NNS
cord-336510-qzm9wgde	408	17	from	from	IN
cord-336510-qzm9wgde	408	18	the	the	DT
cord-336510-qzm9wgde	408	19	different	different	JJ
cord-336510-qzm9wgde	408	20	mice	mouse	NNS
cord-336510-qzm9wgde	408	21	to	to	TO
cord-336510-qzm9wgde	408	22	replicate	replicate	VB
cord-336510-qzm9wgde	408	23	HSV	HSV	NNP
cord-336510-qzm9wgde	408	24	equally	equally	RB
cord-336510-qzm9wgde	408	25	,	,	,
cord-336510-qzm9wgde	408	26	and	and	CC
cord-336510-qzm9wgde	408	27	the	the	DT
cord-336510-qzm9wgde	408	28	same	same	JJ
cord-336510-qzm9wgde	408	29	was	be	VBD
cord-336510-qzm9wgde	408	30	found	find	VBN
cord-336510-qzm9wgde	408	31	in	in	IN
cord-336510-qzm9wgde	408	32	the	the	DT
cord-336510-qzm9wgde	408	33	cells	cell	NNS
cord-336510-qzm9wgde	408	34	showing	show	VBG
cord-336510-qzm9wgde	408	35	differential	differential	JJ
cord-336510-qzm9wgde	408	36	sensitivity	sensitivity	NN
cord-336510-qzm9wgde	408	37	to	to	IN
cord-336510-qzm9wgde	408	38	IFN	IFN	NNP
cord-336510-qzm9wgde	408	39	-	-	HYPH
cord-336510-qzm9wgde	408	40	α	α	NNP
cord-336510-qzm9wgde	408	41	/	/	SYM
cord-336510-qzm9wgde	408	42	β	β	NN
cord-336510-qzm9wgde	408	43	[	[	-LRB-
cord-336510-qzm9wgde	408	44	288	288	CD
cord-336510-qzm9wgde	408	45	,	,	,
cord-336510-qzm9wgde	408	46	322	322	CD
cord-336510-qzm9wgde	408	47	]	]	-RRB-
cord-336510-qzm9wgde	408	48	.	.	.
cord-336510-qzm9wgde	409	1	In	in	IN
cord-336510-qzm9wgde	409	2	line	line	NN
cord-336510-qzm9wgde	409	3	with	with	IN
cord-336510-qzm9wgde	409	4	these	these	DT
cord-336510-qzm9wgde	409	5	results	result	NNS
cord-336510-qzm9wgde	409	6	,	,	,
cord-336510-qzm9wgde	409	7	the	the	DT
cord-336510-qzm9wgde	409	8	IFN	IFN	NNP
cord-336510-qzm9wgde	409	9	-	-	HYPH
cord-336510-qzm9wgde	409	10	activated	activate	VBN
cord-336510-qzm9wgde	409	11	OAS	OAS	NNP
cord-336510-qzm9wgde	409	12	,	,	,
cord-336510-qzm9wgde	409	13	an	an	DT
cord-336510-qzm9wgde	409	14	inhibitor	inhibitor	NN
cord-336510-qzm9wgde	409	15	of	of	IN
cord-336510-qzm9wgde	409	16	HSV	HSV	NNP
cord-336510-qzm9wgde	409	17	replication	replication	NN
cord-336510-qzm9wgde	409	18	,	,	,
cord-336510-qzm9wgde	409	19	was	be	VBD
cord-336510-qzm9wgde	409	20	induced	induce	VBN
cord-336510-qzm9wgde	409	21	to	to	IN
cord-336510-qzm9wgde	409	22	a	a	DT
cord-336510-qzm9wgde	409	23	higher	high	JJR
cord-336510-qzm9wgde	409	24	degree	degree	NN
cord-336510-qzm9wgde	409	25	in	in	IN
cord-336510-qzm9wgde	409	26	cells	cell	NNS
cord-336510-qzm9wgde	409	27	from	from	IN
cord-336510-qzm9wgde	409	28	the	the	DT
cord-336510-qzm9wgde	409	29	resistant	resistant	JJ
cord-336510-qzm9wgde	409	30	mice	mouse	NNS
cord-336510-qzm9wgde	409	31	upon	upon	IN
cord-336510-qzm9wgde	409	32	IFN	IFN	NNP
cord-336510-qzm9wgde	409	33	-	-	HYPH
cord-336510-qzm9wgde	409	34	α	α	NNP
cord-336510-qzm9wgde	409	35	/	/	SYM
cord-336510-qzm9wgde	409	36	β	β	NN
cord-336510-qzm9wgde	409	37	treatment	treatment	NN
cord-336510-qzm9wgde	409	38	[	[	-LRB-
cord-336510-qzm9wgde	409	39	322	322	CD
cord-336510-qzm9wgde	409	40	,	,	,
cord-336510-qzm9wgde	409	41	333	333	CD
cord-336510-qzm9wgde	409	42	,	,	,
cord-336510-qzm9wgde	409	43	338	338	CD
cord-336510-qzm9wgde	409	44	]	]	-RRB-
cord-336510-qzm9wgde	409	45	.	.	.
cord-336510-qzm9wgde	410	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	410	2	,	,	,
cord-336510-qzm9wgde	410	3	the	the	DT
cord-336510-qzm9wgde	410	4	level	level	NN
cord-336510-qzm9wgde	410	5	of	of	IN
cord-336510-qzm9wgde	410	6	stimulated	stimulate	VBN
cord-336510-qzm9wgde	410	7	and	and	CC
cord-336510-qzm9wgde	410	8	unstimulated	unstimulated	JJ
cord-336510-qzm9wgde	410	9	OAS	OAS	NNP
cord-336510-qzm9wgde	410	10	was	be	VBD
cord-336510-qzm9wgde	410	11	generally	generally	RB
cord-336510-qzm9wgde	410	12	found	find	VBN
cord-336510-qzm9wgde	410	13	to	to	TO
cord-336510-qzm9wgde	410	14	vary	vary	VB
cord-336510-qzm9wgde	410	15	between	between	IN
cord-336510-qzm9wgde	410	16	different	different	JJ
cord-336510-qzm9wgde	410	17	inbred	inbred	JJ
cord-336510-qzm9wgde	410	18	mouse	mouse	NN
cord-336510-qzm9wgde	410	19	strains	strain	NNS
cord-336510-qzm9wgde	410	20	[	[	-LRB-
cord-336510-qzm9wgde	410	21	339	339	CD
cord-336510-qzm9wgde	410	22	]	]	-RRB-
cord-336510-qzm9wgde	410	23	.	.	.
cord-336510-qzm9wgde	411	1	Thus	thus	RB
cord-336510-qzm9wgde	411	2	,	,	,
cord-336510-qzm9wgde	411	3	the	the	DT
cord-336510-qzm9wgde	411	4	genetic	genetic	JJ
cord-336510-qzm9wgde	411	5	difference	difference	NN
cord-336510-qzm9wgde	411	6	in	in	IN
cord-336510-qzm9wgde	411	7	antiviral	antiviral	JJ
cord-336510-qzm9wgde	411	8	action	action	NN
cord-336510-qzm9wgde	411	9	of	of	IN
cord-336510-qzm9wgde	411	10	type	type	NN
cord-336510-qzm9wgde	411	11	I	-PRON-	PRP
cord-336510-qzm9wgde	411	12	IFNs	ifns	VBP
cord-336510-qzm9wgde	411	13	seems	seem	VBZ
cord-336510-qzm9wgde	411	14	to	to	TO
cord-336510-qzm9wgde	411	15	affect	affect	VB
cord-336510-qzm9wgde	411	16	the	the	DT
cord-336510-qzm9wgde	411	17	replication	replication	NN
cord-336510-qzm9wgde	411	18	of	of	IN
cord-336510-qzm9wgde	411	19	several	several	JJ
cord-336510-qzm9wgde	411	20	different	different	JJ
cord-336510-qzm9wgde	411	21	viruses	virus	NNS
cord-336510-qzm9wgde	411	22	and	and	CC
cord-336510-qzm9wgde	411	23	to	to	TO
cord-336510-qzm9wgde	411	24	correlate	correlate	VB
cord-336510-qzm9wgde	411	25	with	with	IN
cord-336510-qzm9wgde	411	26	resistance	resistance	NN
cord-336510-qzm9wgde	411	27	to	to	IN
cord-336510-qzm9wgde	411	28	HSV	HSV	NNP
cord-336510-qzm9wgde	411	29	.	.	.
cord-336510-qzm9wgde	412	1	The	the	DT
cord-336510-qzm9wgde	412	2	viral	viral	JJ
cord-336510-qzm9wgde	412	3	host	host	NN
cord-336510-qzm9wgde	412	4	protein	protein	NN
cord-336510-qzm9wgde	412	5	synthesis	synthesis	NN
cord-336510-qzm9wgde	412	6	shutoff	shutoff	NN
cord-336510-qzm9wgde	412	7	,	,	,
cord-336510-qzm9wgde	412	8	exerted	exert	VBN
cord-336510-qzm9wgde	412	9	by	by	IN
cord-336510-qzm9wgde	412	10	the	the	DT
cord-336510-qzm9wgde	412	11	HSV	HSV	NNP
cord-336510-qzm9wgde	412	12	vhs	vhs	NN
cord-336510-qzm9wgde	412	13	-	-	HYPH
cord-336510-qzm9wgde	412	14	protein	protein	NN
cord-336510-qzm9wgde	412	15	of	of	IN
cord-336510-qzm9wgde	412	16	the	the	DT
cord-336510-qzm9wgde	412	17	tegument	tegument	NN
cord-336510-qzm9wgde	412	18	,	,	,
cord-336510-qzm9wgde	412	19	has	have	VBZ
cord-336510-qzm9wgde	412	20	major	major	JJ
cord-336510-qzm9wgde	412	21	effects	effect	NNS
cord-336510-qzm9wgde	412	22	on	on	IN
cord-336510-qzm9wgde	412	23	the	the	DT
cord-336510-qzm9wgde	412	24	cytokine	cytokine	NN
cord-336510-qzm9wgde	412	25	production	production	NN
cord-336510-qzm9wgde	412	26	of	of	IN
cord-336510-qzm9wgde	412	27	infected	infected	JJ
cord-336510-qzm9wgde	412	28	cells	cell	NNS
cord-336510-qzm9wgde	412	29	and	and	CC
cord-336510-qzm9wgde	412	30	reduces	reduce	VBZ
cord-336510-qzm9wgde	412	31	the	the	DT
cord-336510-qzm9wgde	412	32	effect	effect	NN
cord-336510-qzm9wgde	412	33	of	of	IN
cord-336510-qzm9wgde	412	34	IFN	IFN	NNP
cord-336510-qzm9wgde	412	35	-	-	HYPH
cord-336510-qzm9wgde	412	36	α	α	NNP
cord-336510-qzm9wgde	412	37	/	/	SYM
cord-336510-qzm9wgde	412	38	β	β	NN
cord-336510-qzm9wgde	412	39	on	on	IN
cord-336510-qzm9wgde	412	40	HSV	HSV	NNP
cord-336510-qzm9wgde	412	41	replication	replication	NN
cord-336510-qzm9wgde	412	42	[	[	-LRB-
cord-336510-qzm9wgde	412	43	340	340	CD
cord-336510-qzm9wgde	412	44	]	]	-RRB-
cord-336510-qzm9wgde	412	45	.	.	.
cord-336510-qzm9wgde	413	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	413	2	,	,	,
cord-336510-qzm9wgde	413	3	the	the	DT
cord-336510-qzm9wgde	413	4	tegument	tegument	NN
cord-336510-qzm9wgde	413	5	proteins	protein	NNS
cord-336510-qzm9wgde	413	6	have	have	VBP
cord-336510-qzm9wgde	413	7	been	be	VBN
cord-336510-qzm9wgde	413	8	shown	show	VBN
cord-336510-qzm9wgde	413	9	to	to	TO
cord-336510-qzm9wgde	413	10	induce	induce	VB
cord-336510-qzm9wgde	413	11	cellular	cellular	JJ
cord-336510-qzm9wgde	413	12	inhibitors	inhibitor	NNS
cord-336510-qzm9wgde	413	13	of	of	IN
cord-336510-qzm9wgde	413	14	the	the	DT
cord-336510-qzm9wgde	413	15	JAK	JAK	NNP
cord-336510-qzm9wgde	413	16	/	/	SYM
cord-336510-qzm9wgde	413	17	STAT	stat	NN
cord-336510-qzm9wgde	413	18	pathway	pathway	NN
cord-336510-qzm9wgde	413	19	,	,	,
cord-336510-qzm9wgde	413	20	resulting	result	VBG
cord-336510-qzm9wgde	413	21	in	in	IN
cord-336510-qzm9wgde	413	22	inhibition	inhibition	NN
cord-336510-qzm9wgde	413	23	of	of	IN
cord-336510-qzm9wgde	413	24	both	both	CC
cord-336510-qzm9wgde	413	25	IFN	IFN	NNP
cord-336510-qzm9wgde	413	26	signalling	signal	VBG
cord-336510-qzm9wgde	413	27	and	and	CC
cord-336510-qzm9wgde	413	28	production	production	NN
cord-336510-qzm9wgde	413	29	[	[	-LRB-
cord-336510-qzm9wgde	413	30	341	341	CD
cord-336510-qzm9wgde	413	31	,	,	,
cord-336510-qzm9wgde	413	32	342	342	CD
cord-336510-qzm9wgde	413	33	]	]	-RRB-
cord-336510-qzm9wgde	413	34	.	.	.
cord-336510-qzm9wgde	414	1	The	the	DT
cord-336510-qzm9wgde	414	2	IE	IE	NNP
cord-336510-qzm9wgde	414	3	protein	protein	NN
cord-336510-qzm9wgde	414	4	ICP0	ICP0	NNP
cord-336510-qzm9wgde	414	5	inhibits	inhibit	VBZ
cord-336510-qzm9wgde	414	6	activation	activation	NN
cord-336510-qzm9wgde	414	7	of	of	IN
cord-336510-qzm9wgde	414	8	IRF-3	IRF-3	NNP
cord-336510-qzm9wgde	414	9	and	and	CC
cord-336510-qzm9wgde	414	10	thereby	thereby	RB
cord-336510-qzm9wgde	414	11	also	also	RB
cord-336510-qzm9wgde	414	12	restricts	restrict	VBZ
cord-336510-qzm9wgde	414	13	IFN	IFN	NNP
cord-336510-qzm9wgde	414	14	-	-	HYPH
cord-336510-qzm9wgde	414	15	induced	induce	VBN
cord-336510-qzm9wgde	414	16	pathways	pathway	NNS
cord-336510-qzm9wgde	414	17	[	[	-LRB-
cord-336510-qzm9wgde	414	18	71	71	CD
cord-336510-qzm9wgde	414	19	-	-	SYM
cord-336510-qzm9wgde	414	20	73	73	CD
cord-336510-qzm9wgde	414	21	]	]	-RRB-
cord-336510-qzm9wgde	414	22	,	,	,
cord-336510-qzm9wgde	414	23	and	and	CC
cord-336510-qzm9wgde	414	24	ICP0	ICP0	NNP
cord-336510-qzm9wgde	414	25	,	,	,
cord-336510-qzm9wgde	414	26	ICP4	ICP4	NNP
cord-336510-qzm9wgde	414	27	and	and	CC
cord-336510-qzm9wgde	414	28	ICP27	ICP27	NNP
cord-336510-qzm9wgde	414	29	induce	induce	VBP
cord-336510-qzm9wgde	414	30	late	late	JJ
cord-336510-qzm9wgde	414	31	shutoff	shutoff	NN
cord-336510-qzm9wgde	414	32	of	of	IN
cord-336510-qzm9wgde	414	33	protein	protein	NN
cord-336510-qzm9wgde	414	34	synthesis	synthesis	NN
cord-336510-qzm9wgde	414	35	with	with	IN
cord-336510-qzm9wgde	414	36	decreased	decrease	VBN
cord-336510-qzm9wgde	414	37	mRNA	mrna	NN
cord-336510-qzm9wgde	414	38	stability	stability	NN
cord-336510-qzm9wgde	414	39	and	and	CC
cord-336510-qzm9wgde	414	40	thus	thus	RB
cord-336510-qzm9wgde	414	41	reduced	reduce	VBN
cord-336510-qzm9wgde	414	42	cytokine	cytokine	NN
cord-336510-qzm9wgde	414	43	production	production	NN
cord-336510-qzm9wgde	414	44	[	[	-LRB-
cord-336510-qzm9wgde	414	45	81,343	81,343	CD
cord-336510-qzm9wgde	414	46	]	]	-RRB-
cord-336510-qzm9wgde	414	47	.	.	.
cord-336510-qzm9wgde	415	1	As	as	IN
cord-336510-qzm9wgde	415	2	outlined	outline	VBN
cord-336510-qzm9wgde	415	3	,	,	,
cord-336510-qzm9wgde	415	4	it	-PRON-	PRP
cord-336510-qzm9wgde	415	5	thus	thus	RB
cord-336510-qzm9wgde	415	6	seems	seem	VBZ
cord-336510-qzm9wgde	415	7	HSV	HSV	NNP
cord-336510-qzm9wgde	415	8	has	have	VBZ
cord-336510-qzm9wgde	415	9	evolved	evolve	VBN
cord-336510-qzm9wgde	415	10	several	several	JJ
cord-336510-qzm9wgde	415	11	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	415	12	to	to	TO
cord-336510-qzm9wgde	415	13	evade	evade	VB
cord-336510-qzm9wgde	415	14	the	the	DT
cord-336510-qzm9wgde	415	15	consequences	consequence	NNS
cord-336510-qzm9wgde	415	16	of	of	IN
cord-336510-qzm9wgde	415	17	the	the	DT
cord-336510-qzm9wgde	415	18	IFN	IFN	NNP
cord-336510-qzm9wgde	415	19	-	-	HYPH
cord-336510-qzm9wgde	415	20	α	α	NNP
cord-336510-qzm9wgde	415	21	/	/	SYM
cord-336510-qzm9wgde	415	22	β	β	NN
cord-336510-qzm9wgde	415	23	system	system	NN
cord-336510-qzm9wgde	415	24	,	,	,
cord-336510-qzm9wgde	415	25	which	which	WDT
cord-336510-qzm9wgde	415	26	underline	underline	VBP
cord-336510-qzm9wgde	415	27	the	the	DT
cord-336510-qzm9wgde	415	28	importance	importance	NN
cord-336510-qzm9wgde	415	29	of	of	IN
cord-336510-qzm9wgde	415	30	these	these	DT
cord-336510-qzm9wgde	415	31	cytokines	cytokine	NNS
cord-336510-qzm9wgde	415	32	in	in	IN
cord-336510-qzm9wgde	415	33	the	the	DT
cord-336510-qzm9wgde	415	34	antiviral	antiviral	JJ
cord-336510-qzm9wgde	415	35	defence	defence	NN
cord-336510-qzm9wgde	415	36	.	.	.
cord-336510-qzm9wgde	416	1	During	during	IN
cord-336510-qzm9wgde	416	2	HSV	HSV	NNP
cord-336510-qzm9wgde	416	3	infection	infection	NN
cord-336510-qzm9wgde	416	4	macrophages	macrophage	NNS
cord-336510-qzm9wgde	416	5	are	be	VBP
cord-336510-qzm9wgde	416	6	activated	activate	VBN
cord-336510-qzm9wgde	416	7	and	and	CC
cord-336510-qzm9wgde	416	8	possess	possess	VBP
cord-336510-qzm9wgde	416	9	an	an	DT
cord-336510-qzm9wgde	416	10	increased	increase	VBN
cord-336510-qzm9wgde	416	11	antiviral	antiviral	JJ
cord-336510-qzm9wgde	416	12	potential	potential	NN
cord-336510-qzm9wgde	416	13	[	[	-LRB-
cord-336510-qzm9wgde	416	14	281	281	CD
cord-336510-qzm9wgde	416	15	,	,	,
cord-336510-qzm9wgde	416	16	344	344	CD
cord-336510-qzm9wgde	416	17	]	]	-RRB-
cord-336510-qzm9wgde	416	18	.	.	.
cord-336510-qzm9wgde	417	1	Classically	classically	RB
cord-336510-qzm9wgde	417	2	,	,	,
cord-336510-qzm9wgde	417	3	the	the	DT
cord-336510-qzm9wgde	417	4	macrophage	macrophage	NN
cord-336510-qzm9wgde	417	5	antiviral	antiviral	JJ
cord-336510-qzm9wgde	417	6	activity	activity	NN
cord-336510-qzm9wgde	417	7	has	have	VBZ
cord-336510-qzm9wgde	417	8	been	be	VBN
cord-336510-qzm9wgde	417	9	described	describe	VBN
cord-336510-qzm9wgde	417	10	as	as	IN
cord-336510-qzm9wgde	417	11	intrinsic	intrinsic	JJ
cord-336510-qzm9wgde	417	12	or	or	CC
cord-336510-qzm9wgde	417	13	extrinsic	extrinsic	JJ
cord-336510-qzm9wgde	417	14	[	[	-LRB-
cord-336510-qzm9wgde	417	15	345	345	CD
cord-336510-qzm9wgde	417	16	]	]	-RRB-
cord-336510-qzm9wgde	417	17	.	.	.
cord-336510-qzm9wgde	418	1	Resting	rest	VBG
cord-336510-qzm9wgde	418	2	macrophages	macrophage	NNS
cord-336510-qzm9wgde	418	3	possess	possess	VBP
cord-336510-qzm9wgde	418	4	a	a	DT
cord-336510-qzm9wgde	418	5	high	high	JJ
cord-336510-qzm9wgde	418	6	degree	degree	NN
cord-336510-qzm9wgde	418	7	of	of	IN
cord-336510-qzm9wgde	418	8	intrinsic	intrinsic	JJ
cord-336510-qzm9wgde	418	9	activity	activity	NN
cord-336510-qzm9wgde	418	10	against	against	IN
cord-336510-qzm9wgde	418	11	HSV	HSV	NNP
cord-336510-qzm9wgde	418	12	,	,	,
cord-336510-qzm9wgde	418	13	generally	generally	RB
cord-336510-qzm9wgde	418	14	being	be	VBG
cord-336510-qzm9wgde	418	15	non	non	JJ
cord-336510-qzm9wgde	418	16	-	-	JJ
cord-336510-qzm9wgde	418	17	permissive	permissive	JJ
cord-336510-qzm9wgde	418	18	to	to	IN
cord-336510-qzm9wgde	418	19	viral	viral	JJ
cord-336510-qzm9wgde	418	20	replication	replication	NN
cord-336510-qzm9wgde	418	21	.	.	.
cord-336510-qzm9wgde	419	1	The	the	DT
cord-336510-qzm9wgde	419	2	macrophages	macrophage	NNS
cord-336510-qzm9wgde	419	3	are	be	VBP
cord-336510-qzm9wgde	419	4	thus	thus	RB
cord-336510-qzm9wgde	419	5	a	a	DT
cord-336510-qzm9wgde	419	6	blind	blind	JJ
cord-336510-qzm9wgde	419	7	end	end	NN
cord-336510-qzm9wgde	419	8	for	for	IN
cord-336510-qzm9wgde	419	9	the	the	DT
cord-336510-qzm9wgde	419	10	HSV	HSV	NNP
cord-336510-qzm9wgde	419	11	infection	infection	NN
cord-336510-qzm9wgde	419	12	,	,	,
cord-336510-qzm9wgde	419	13	and	and	CC
cord-336510-qzm9wgde	419	14	they	-PRON-	PRP
cord-336510-qzm9wgde	419	15	can	can	MD
cord-336510-qzm9wgde	419	16	in	in	IN
cord-336510-qzm9wgde	419	17	that	that	DT
cord-336510-qzm9wgde	419	18	way	way	NN
cord-336510-qzm9wgde	419	19	protect	protect	VB
cord-336510-qzm9wgde	419	20	other	other	JJ
cord-336510-qzm9wgde	419	21	cells	cell	NNS
cord-336510-qzm9wgde	419	22	from	from	IN
cord-336510-qzm9wgde	419	23	infection	infection	NN
cord-336510-qzm9wgde	419	24	,	,	,
cord-336510-qzm9wgde	419	25	for	for	IN
cord-336510-qzm9wgde	419	26	example	example	NN
cord-336510-qzm9wgde	419	27	as	as	IN
cord-336510-qzm9wgde	419	28	a	a	DT
cord-336510-qzm9wgde	419	29	barrier	barrier	NN
cord-336510-qzm9wgde	419	30	lining	line	VBG
cord-336510-qzm9wgde	419	31	the	the	DT
cord-336510-qzm9wgde	419	32	liver	liver	NN
cord-336510-qzm9wgde	419	33	sinusoids	sinusoid	NNS
cord-336510-qzm9wgde	419	34	[	[	-LRB-
cord-336510-qzm9wgde	419	35	344	344	CD
cord-336510-qzm9wgde	419	36	]	]	-RRB-
cord-336510-qzm9wgde	419	37	.	.	.
cord-336510-qzm9wgde	420	1	The	the	DT
cord-336510-qzm9wgde	420	2	extrinsic	extrinsic	JJ
cord-336510-qzm9wgde	420	3	antiviral	antiviral	JJ
cord-336510-qzm9wgde	420	4	activity	activity	NN
cord-336510-qzm9wgde	420	5	refers	refer	VBZ
cord-336510-qzm9wgde	420	6	to	to	IN
cord-336510-qzm9wgde	420	7	the	the	DT
cord-336510-qzm9wgde	420	8	ability	ability	NN
cord-336510-qzm9wgde	420	9	of	of	IN
cord-336510-qzm9wgde	420	10	macrophages	macrophage	NNS
cord-336510-qzm9wgde	420	11	to	to	TO
cord-336510-qzm9wgde	420	12	inactivate	inactivate	VB
cord-336510-qzm9wgde	420	13	virus	virus	NN
cord-336510-qzm9wgde	420	14	outside	outside	IN
cord-336510-qzm9wgde	420	15	the	the	DT
cord-336510-qzm9wgde	420	16	macrophage	macrophage	NN
cord-336510-qzm9wgde	420	17	itself	-PRON-	PRP
cord-336510-qzm9wgde	420	18	or	or	CC
cord-336510-qzm9wgde	420	19	to	to	TO
cord-336510-qzm9wgde	420	20	inhibit	inhibit	VB
cord-336510-qzm9wgde	420	21	viral	viral	JJ
cord-336510-qzm9wgde	420	22	replication	replication	NN
cord-336510-qzm9wgde	420	23	in	in	IN
cord-336510-qzm9wgde	420	24	other	other	JJ
cord-336510-qzm9wgde	420	25	cells	cell	NNS
cord-336510-qzm9wgde	420	26	[	[	-LRB-
cord-336510-qzm9wgde	420	27	346	346	CD
cord-336510-qzm9wgde	420	28	]	]	-RRB-
cord-336510-qzm9wgde	420	29	.	.	.
cord-336510-qzm9wgde	421	1	The	the	DT
cord-336510-qzm9wgde	421	2	intrinsic	intrinsic	JJ
cord-336510-qzm9wgde	421	3	antiviral	antiviral	JJ
cord-336510-qzm9wgde	421	4	activity	activity	NN
cord-336510-qzm9wgde	421	5	depends	depend	VBZ
cord-336510-qzm9wgde	421	6	among	among	IN
cord-336510-qzm9wgde	421	7	other	other	JJ
cord-336510-qzm9wgde	421	8	factors	factor	NNS
cord-336510-qzm9wgde	421	9	on	on	IN
cord-336510-qzm9wgde	421	10	macrophage	macrophage	NN
cord-336510-qzm9wgde	421	11	differentiation	differentiation	NN
cord-336510-qzm9wgde	421	12	and	and	CC
cord-336510-qzm9wgde	421	13	has	have	VBZ
cord-336510-qzm9wgde	421	14	been	be	VBN
cord-336510-qzm9wgde	421	15	correlated	correlate	VBN
cord-336510-qzm9wgde	421	16	to	to	IN
cord-336510-qzm9wgde	421	17	IFN	IFN	NNP
cord-336510-qzm9wgde	421	18	activity	activity	NN
cord-336510-qzm9wgde	421	19	,	,	,
cord-336510-qzm9wgde	421	20	either	either	CC
cord-336510-qzm9wgde	421	21	physiological	physiological	JJ
cord-336510-qzm9wgde	421	22	levels	level	NNS
cord-336510-qzm9wgde	421	23	of	of	IN
cord-336510-qzm9wgde	421	24	"	"	``
cord-336510-qzm9wgde	421	25	spontaneous	spontaneous	JJ
cord-336510-qzm9wgde	421	26	"	"	''
cord-336510-qzm9wgde	421	27	preinfection	preinfection	NN
cord-336510-qzm9wgde	421	28	-	-	HYPH
cord-336510-qzm9wgde	421	29	synthesized	synthesize	VBN
cord-336510-qzm9wgde	421	30	or	or	CC
cord-336510-qzm9wgde	421	31	rapidly	rapidly	RB
cord-336510-qzm9wgde	421	32	acting	act	VBG
cord-336510-qzm9wgde	421	33	autocrine	autocrine	NN
cord-336510-qzm9wgde	421	34	IFN	IFN	NNP
cord-336510-qzm9wgde	421	35	-	-	HYPH
cord-336510-qzm9wgde	421	36	α	α	NNP
cord-336510-qzm9wgde	421	37	/	/	SYM
cord-336510-qzm9wgde	421	38	β	β	NN
cord-336510-qzm9wgde	421	39	[	[	-LRB-
cord-336510-qzm9wgde	421	40	344	344	CD
cord-336510-qzm9wgde	421	41	]	]	-RRB-
cord-336510-qzm9wgde	421	42	.	.	.
cord-336510-qzm9wgde	422	1	In	in	IN
cord-336510-qzm9wgde	422	2	that	that	DT
cord-336510-qzm9wgde	422	3	respect	respect	NN
cord-336510-qzm9wgde	422	4	,	,	,
cord-336510-qzm9wgde	422	5	macrophages	macrophage	NNS
cord-336510-qzm9wgde	422	6	from	from	IN
cord-336510-qzm9wgde	422	7	mice	mouse	NNS
cord-336510-qzm9wgde	422	8	of	of	IN
cord-336510-qzm9wgde	422	9	the	the	DT
cord-336510-qzm9wgde	422	10	resistant	resistant	JJ
cord-336510-qzm9wgde	422	11	phenotype	phenotype	NN
cord-336510-qzm9wgde	422	12	showed	show	VBD
cord-336510-qzm9wgde	422	13	higher	high	JJR
cord-336510-qzm9wgde	422	14	intrinsic	intrinsic	JJ
cord-336510-qzm9wgde	422	15	activity	activity	NN
cord-336510-qzm9wgde	422	16	by	by	IN
cord-336510-qzm9wgde	422	17	being	be	VBG
cord-336510-qzm9wgde	422	18	less	less	RBR
cord-336510-qzm9wgde	422	19	permissive	permissive	JJ
cord-336510-qzm9wgde	422	20	to	to	IN
cord-336510-qzm9wgde	422	21	HSV	HSV	NNP
cord-336510-qzm9wgde	422	22	replication	replication	NN
cord-336510-qzm9wgde	422	23	[	[	-LRB-
cord-336510-qzm9wgde	422	24	281	281	CD
cord-336510-qzm9wgde	422	25	,	,	,
cord-336510-qzm9wgde	422	26	347	347	CD
cord-336510-qzm9wgde	422	27	]	]	-RRB-
cord-336510-qzm9wgde	422	28	.	.	.
cord-336510-qzm9wgde	423	1	One	one	CD
cord-336510-qzm9wgde	423	2	potential	potential	JJ
cord-336510-qzm9wgde	423	3	antiviral	antiviral	JJ
cord-336510-qzm9wgde	423	4	mechanism	mechanism	NN
cord-336510-qzm9wgde	423	5	of	of	IN
cord-336510-qzm9wgde	423	6	macrophages	macrophage	NNS
cord-336510-qzm9wgde	423	7	may	may	MD
cord-336510-qzm9wgde	423	8	be	be	VB
cord-336510-qzm9wgde	423	9	the	the	DT
cord-336510-qzm9wgde	423	10	production	production	NN
cord-336510-qzm9wgde	423	11	of	of	IN
cord-336510-qzm9wgde	423	12	ROS	ROS	NNP
cord-336510-qzm9wgde	423	13	.	.	.
cord-336510-qzm9wgde	424	1	These	these	DT
cord-336510-qzm9wgde	424	2	were	be	VBD
cord-336510-qzm9wgde	424	3	originally	originally	RB
cord-336510-qzm9wgde	424	4	assigned	assign	VBN
cord-336510-qzm9wgde	424	5	to	to	IN
cord-336510-qzm9wgde	424	6	bacterial	bacterial	JJ
cord-336510-qzm9wgde	424	7	killing	killing	NN
cord-336510-qzm9wgde	424	8	,	,	,
cord-336510-qzm9wgde	424	9	but	but	CC
cord-336510-qzm9wgde	424	10	the	the	DT
cord-336510-qzm9wgde	424	11	effect	effect	NN
cord-336510-qzm9wgde	424	12	of	of	IN
cord-336510-qzm9wgde	424	13	ROS	ROS	NNP
cord-336510-qzm9wgde	424	14	has	have	VBZ
cord-336510-qzm9wgde	424	15	also	also	RB
cord-336510-qzm9wgde	424	16	been	be	VBN
cord-336510-qzm9wgde	424	17	correlated	correlate	VBN
cord-336510-qzm9wgde	424	18	to	to	IN
cord-336510-qzm9wgde	424	19	antiviral	antiviral	JJ
cord-336510-qzm9wgde	424	20	functions	function	NNS
cord-336510-qzm9wgde	424	21	,	,	,
cord-336510-qzm9wgde	424	22	although	although	IN
cord-336510-qzm9wgde	424	23	they	-PRON-	PRP
cord-336510-qzm9wgde	424	24	might	may	MD
cord-336510-qzm9wgde	424	25	not	not	RB
cord-336510-qzm9wgde	424	26	be	be	VB
cord-336510-qzm9wgde	424	27	of	of	IN
cord-336510-qzm9wgde	424	28	major	major	JJ
cord-336510-qzm9wgde	424	29	importance	importance	NN
cord-336510-qzm9wgde	424	30	[	[	-LRB-
cord-336510-qzm9wgde	424	31	348	348	CD
cord-336510-qzm9wgde	424	32	]	]	-RRB-
cord-336510-qzm9wgde	424	33	.	.	.
cord-336510-qzm9wgde	425	1	The	the	DT
cord-336510-qzm9wgde	425	2	ROS	ROS	NNP
cord-336510-qzm9wgde	425	3	are	be	VBP
cord-336510-qzm9wgde	425	4	mainly	mainly	RB
cord-336510-qzm9wgde	425	5	produced	produce	VBN
cord-336510-qzm9wgde	425	6	by	by	IN
cord-336510-qzm9wgde	425	7	NADPH	NADPH	NNP
cord-336510-qzm9wgde	425	8	-	-	HYPH
cord-336510-qzm9wgde	425	9	oxidases	oxidase	NNS
cord-336510-qzm9wgde	425	10	(	(	-LRB-
cord-336510-qzm9wgde	425	11	Nox	Nox	NNP
cord-336510-qzm9wgde	425	12	)	)	-RRB-
cord-336510-qzm9wgde	425	13	,	,	,
cord-336510-qzm9wgde	425	14	which	which	WDT
cord-336510-qzm9wgde	425	15	are	be	VBP
cord-336510-qzm9wgde	425	16	membrane	membrane	NN
cord-336510-qzm9wgde	425	17	-	-	HYPH
cord-336510-qzm9wgde	425	18	bound	bind	VBN
cord-336510-qzm9wgde	425	19	multi	multi	JJ
cord-336510-qzm9wgde	425	20	-	-	JJ
cord-336510-qzm9wgde	425	21	component	component	NN
cord-336510-qzm9wgde	425	22	enzymes	enzyme	NNS
cord-336510-qzm9wgde	425	23	primarily	primarily	RB
cord-336510-qzm9wgde	425	24	situated	situate	VBN
cord-336510-qzm9wgde	425	25	in	in	IN
cord-336510-qzm9wgde	425	26	the	the	DT
cord-336510-qzm9wgde	425	27	phagolysosome	phagolysosome	NN
cord-336510-qzm9wgde	425	28	[	[	-LRB-
cord-336510-qzm9wgde	425	29	349	349	CD
cord-336510-qzm9wgde	425	30	]	]	-RRB-
cord-336510-qzm9wgde	425	31	.	.	.
cord-336510-qzm9wgde	426	1	Activation	activation	NN
cord-336510-qzm9wgde	426	2	of	of	IN
cord-336510-qzm9wgde	426	3	the	the	DT
cord-336510-qzm9wgde	426	4	NAHPD	nahpd	NN
cord-336510-qzm9wgde	426	5	-	-	HYPH
cord-336510-qzm9wgde	426	6	oxidase	oxidase	NN
cord-336510-qzm9wgde	426	7	,	,	,
cord-336510-qzm9wgde	426	8	by	by	IN
cord-336510-qzm9wgde	426	9	phosphorylation	phosphorylation	NN
cord-336510-qzm9wgde	426	10	and	and	CC
cord-336510-qzm9wgde	426	11	fusion	fusion	NN
cord-336510-qzm9wgde	426	12	of	of	IN
cord-336510-qzm9wgde	426	13	the	the	DT
cord-336510-qzm9wgde	426	14	enzyme	enzyme	NN
cord-336510-qzm9wgde	426	15	subunits	subunit	NNS
cord-336510-qzm9wgde	426	16	,	,	,
cord-336510-qzm9wgde	426	17	primarily	primarily	RB
cord-336510-qzm9wgde	426	18	results	result	VBZ
cord-336510-qzm9wgde	426	19	in	in	IN
cord-336510-qzm9wgde	426	20	production	production	NN
cord-336510-qzm9wgde	426	21	of	of	IN
cord-336510-qzm9wgde	426	22	superoxide	superoxide	NN
cord-336510-qzm9wgde	426	23	anion	anion	NN
cord-336510-qzm9wgde	426	24	(	(	-LRB-
cord-336510-qzm9wgde	426	25	O	o	UH
cord-336510-qzm9wgde	426	26	2	2	CD
cord-336510-qzm9wgde	426	27	-	-	,
cord-336510-qzm9wgde	426	28	)	)	-RRB-
cord-336510-qzm9wgde	426	29	,	,	,
cord-336510-qzm9wgde	426	30	which	which	WDT
cord-336510-qzm9wgde	426	31	by	by	IN
cord-336510-qzm9wgde	426	32	superoxide	superoxide	NN
cord-336510-qzm9wgde	426	33	dismutase	dismutase	NN
cord-336510-qzm9wgde	426	34	can	can	MD
cord-336510-qzm9wgde	426	35	be	be	VB
cord-336510-qzm9wgde	426	36	converted	convert	VBN
cord-336510-qzm9wgde	426	37	to	to	IN
cord-336510-qzm9wgde	426	38	hydrogen	hydrogen	NN
cord-336510-qzm9wgde	426	39	peroxide	peroxide	NN
cord-336510-qzm9wgde	426	40	(	(	-LRB-
cord-336510-qzm9wgde	426	41	H	h	NN
cord-336510-qzm9wgde	426	42	2	2	CD
cord-336510-qzm9wgde	426	43	O	o	NN
cord-336510-qzm9wgde	426	44	2	2	CD
cord-336510-qzm9wgde	426	45	)	)	-RRB-
cord-336510-qzm9wgde	426	46	.	.	.
cord-336510-qzm9wgde	427	1	The	the	DT
cord-336510-qzm9wgde	427	2	H	h	NN
cord-336510-qzm9wgde	427	3	2	2	CD
cord-336510-qzm9wgde	427	4	O	o	NN
cord-336510-qzm9wgde	427	5	2	2	CD
cord-336510-qzm9wgde	427	6	in	in	IN
cord-336510-qzm9wgde	427	7	turn	turn	NN
cord-336510-qzm9wgde	427	8	is	be	VBZ
cord-336510-qzm9wgde	427	9	then	then	RB
cord-336510-qzm9wgde	427	10	by	by	IN
cord-336510-qzm9wgde	427	11	Fe	Fe	NNP
cord-336510-qzm9wgde	427	12	2	2	CD
cord-336510-qzm9wgde	428	1	+	+	CC
cord-336510-qzm9wgde	428	2	(	(	-LRB-
cord-336510-qzm9wgde	428	3	Fenton	Fenton	NNP
cord-336510-qzm9wgde	428	4	reaction	reaction	NN
cord-336510-qzm9wgde	428	5	)	)	-RRB-
cord-336510-qzm9wgde	428	6	or	or	CC
cord-336510-qzm9wgde	429	1	by	by	IN
cord-336510-qzm9wgde	429	2	Fe	Fe	NNP
cord-336510-qzm9wgde	429	3	3	3	CD
cord-336510-qzm9wgde	430	1	+	+	CC
cord-336510-qzm9wgde	431	1	and	and	CC
cord-336510-qzm9wgde	431	2	O	o	UH
cord-336510-qzm9wgde	431	3	2	2	CD
cord-336510-qzm9wgde	431	4	-(Haber	-(Haber	:
cord-336510-qzm9wgde	431	5	-	-	:
cord-336510-qzm9wgde	431	6	Weiss	Weiss	NNP
cord-336510-qzm9wgde	431	7	reaction	reaction	NN
cord-336510-qzm9wgde	431	8	)	)	-RRB-
cord-336510-qzm9wgde	431	9	converted	convert	VBD
cord-336510-qzm9wgde	431	10	to	to	IN
cord-336510-qzm9wgde	431	11	hydroxyl	hydroxyl	NN
cord-336510-qzm9wgde	431	12	radical	radical	JJ
cord-336510-qzm9wgde	431	13	(	(	-LRB-
cord-336510-qzm9wgde	431	14	·	·	NFP
cord-336510-qzm9wgde	431	15	OH	OH	NNP
cord-336510-qzm9wgde	431	16	)	)	-RRB-
cord-336510-qzm9wgde	431	17	,	,	,
cord-336510-qzm9wgde	431	18	hydroxyl	hydroxyl	NN
cord-336510-qzm9wgde	431	19	anion	anion	NN
cord-336510-qzm9wgde	431	20	(	(	-LRB-
cord-336510-qzm9wgde	431	21	OH	OH	NNP
cord-336510-qzm9wgde	431	22	-	-	,
cord-336510-qzm9wgde	431	23	)	)	-RRB-
cord-336510-qzm9wgde	431	24	and	and	CC
cord-336510-qzm9wgde	431	25	singlet	singlet	NN
cord-336510-qzm9wgde	431	26	oxygen	oxygen	NN
cord-336510-qzm9wgde	431	27	(	(	-LRB-
cord-336510-qzm9wgde	431	28	1	1	CD
cord-336510-qzm9wgde	431	29	O	o	NN
cord-336510-qzm9wgde	431	30	2	2	CD
cord-336510-qzm9wgde	431	31	)	)	-RRB-
cord-336510-qzm9wgde	431	32	,	,	,
cord-336510-qzm9wgde	431	33	or	or	CC
cord-336510-qzm9wgde	431	34	by	by	IN
cord-336510-qzm9wgde	431	35	the	the	DT
cord-336510-qzm9wgde	431	36	myeloperoxidase	myeloperoxidase	NN
cord-336510-qzm9wgde	431	37	to	to	IN
cord-336510-qzm9wgde	431	38	hypochlorous	hypochlorous	JJ
cord-336510-qzm9wgde	431	39	acid	acid	NN
cord-336510-qzm9wgde	431	40	(	(	-LRB-
cord-336510-qzm9wgde	431	41	HOCl	HOCl	NNP
cord-336510-qzm9wgde	431	42	)	)	-RRB-
cord-336510-qzm9wgde	432	1	[	[	-LRB-
cord-336510-qzm9wgde	432	2	349	349	CD
cord-336510-qzm9wgde	432	3	,	,	,
cord-336510-qzm9wgde	432	4	350	350	CD
cord-336510-qzm9wgde	432	5	]	]	-RRB-
cord-336510-qzm9wgde	432	6	.	.	.
cord-336510-qzm9wgde	433	1	Small	small	JJ
cord-336510-qzm9wgde	433	2	amounts	amount	NNS
cord-336510-qzm9wgde	433	3	of	of	IN
cord-336510-qzm9wgde	433	4	ROS	ROS	NNP
cord-336510-qzm9wgde	433	5	are	be	VBP
cord-336510-qzm9wgde	433	6	also	also	RB
cord-336510-qzm9wgde	433	7	produced	produce	VBN
cord-336510-qzm9wgde	433	8	by	by	IN
cord-336510-qzm9wgde	433	9	the	the	DT
cord-336510-qzm9wgde	433	10	mitochondria	mitochondrion	NNS
cord-336510-qzm9wgde	433	11	and	and	CC
cord-336510-qzm9wgde	433	12	may	may	MD
cord-336510-qzm9wgde	433	13	be	be	VB
cord-336510-qzm9wgde	433	14	of	of	IN
cord-336510-qzm9wgde	433	15	importance	importance	NN
cord-336510-qzm9wgde	433	16	as	as	IN
cord-336510-qzm9wgde	433	17	signalling	signal	VBG
cord-336510-qzm9wgde	433	18	molecules	molecule	NNS
cord-336510-qzm9wgde	433	19	from	from	IN
cord-336510-qzm9wgde	433	20	TNF	TNF	NNP
cord-336510-qzm9wgde	433	21	[	[	-LRB-
cord-336510-qzm9wgde	433	22	351	351	CD
cord-336510-qzm9wgde	433	23	,	,	,
cord-336510-qzm9wgde	433	24	352	352	CD
cord-336510-qzm9wgde	433	25	]	]	-RRB-
cord-336510-qzm9wgde	433	26	.	.	.
cord-336510-qzm9wgde	434	1	During	during	IN
cord-336510-qzm9wgde	434	2	HSV	HSV	NNP
cord-336510-qzm9wgde	434	3	infection	infection	NN
cord-336510-qzm9wgde	434	4	in	in	IN
cord-336510-qzm9wgde	434	5	vivo	vivo	NN
cord-336510-qzm9wgde	434	6	,	,	,
cord-336510-qzm9wgde	434	7	macrophages	macrophage	NNS
cord-336510-qzm9wgde	434	8	are	be	VBP
cord-336510-qzm9wgde	434	9	activated	activate	VBN
cord-336510-qzm9wgde	434	10	and	and	CC
cord-336510-qzm9wgde	434	11	achieve	achieve	VB
cord-336510-qzm9wgde	434	12	an	an	DT
cord-336510-qzm9wgde	434	13	increased	increase	VBN
cord-336510-qzm9wgde	434	14	capacity	capacity	NN
cord-336510-qzm9wgde	434	15	to	to	TO
cord-336510-qzm9wgde	434	16	react	react	VB
cord-336510-qzm9wgde	434	17	with	with	IN
cord-336510-qzm9wgde	434	18	a	a	DT
cord-336510-qzm9wgde	434	19	respiratory	respiratory	JJ
cord-336510-qzm9wgde	434	20	burst	burst	NN
cord-336510-qzm9wgde	434	21	of	of	IN
cord-336510-qzm9wgde	434	22	ROS	ROS	NNP
cord-336510-qzm9wgde	434	23	when	when	WRB
cord-336510-qzm9wgde	434	24	appropriately	appropriately	RB
cord-336510-qzm9wgde	434	25	triggered	trigger	VBN
cord-336510-qzm9wgde	434	26	,	,	,
cord-336510-qzm9wgde	434	27	i.e.	i.e.	FW
cord-336510-qzm9wgde	434	28	by	by	IN
cord-336510-qzm9wgde	434	29	phorbol	phorbol	NNP
cord-336510-qzm9wgde	434	30	esters	esters	NNP
cord-336510-qzm9wgde	434	31	(	(	-LRB-
cord-336510-qzm9wgde	434	32	fig	fig	NN
cord-336510-qzm9wgde	434	33	.	.	NNP
cord-336510-qzm9wgde	434	34	2	2	LS
cord-336510-qzm9wgde	434	35	)	)	-RRB-
cord-336510-qzm9wgde	435	1	[	[	-LRB-
cord-336510-qzm9wgde	435	2	353	353	CD
cord-336510-qzm9wgde	435	3	]	]	-RRB-
cord-336510-qzm9wgde	435	4	.	.	.
cord-336510-qzm9wgde	436	1	This	this	DT
cord-336510-qzm9wgde	436	2	macrophage	macrophage	NN
cord-336510-qzm9wgde	436	3	activation	activation	NN
cord-336510-qzm9wgde	436	4	is	be	VBZ
cord-336510-qzm9wgde	436	5	induced	induce	VBN
cord-336510-qzm9wgde	436	6	early	early	RB
cord-336510-qzm9wgde	436	7	in	in	IN
cord-336510-qzm9wgde	436	8	response	response	NN
cord-336510-qzm9wgde	436	9	to	to	IN
cord-336510-qzm9wgde	436	10	HSV	HSV	NNP
cord-336510-qzm9wgde	436	11	infection	infection	NN
cord-336510-qzm9wgde	436	12	,	,	,
cord-336510-qzm9wgde	436	13	reaching	reach	VBG
cord-336510-qzm9wgde	436	14	a	a	DT
cord-336510-qzm9wgde	436	15	plateau	plateau	NN
cord-336510-qzm9wgde	436	16	within	within	IN
cord-336510-qzm9wgde	436	17	the	the	DT
cord-336510-qzm9wgde	436	18	first	first	JJ
cord-336510-qzm9wgde	436	19	12	12	CD
cord-336510-qzm9wgde	436	20	hours	hour	NNS
cord-336510-qzm9wgde	436	21	of	of	IN
cord-336510-qzm9wgde	436	22	i.p	i.p	NNP
cord-336510-qzm9wgde	436	23	.	.	.
cord-336510-qzm9wgde	436	24	infection	infection	NN
cord-336510-qzm9wgde	436	25	[	[	-LRB-
cord-336510-qzm9wgde	436	26	353	353	CD
cord-336510-qzm9wgde	436	27	]	]	-RRB-
cord-336510-qzm9wgde	436	28	.	.	.
cord-336510-qzm9wgde	437	1	In	in	IN
cord-336510-qzm9wgde	437	2	vitro	vitro	FW
cord-336510-qzm9wgde	437	3	,	,	,
cord-336510-qzm9wgde	437	4	macrophages	macrophage	NNS
cord-336510-qzm9wgde	437	5	were	be	VBD
cord-336510-qzm9wgde	437	6	shown	show	VBN
cord-336510-qzm9wgde	437	7	to	to	TO
cord-336510-qzm9wgde	437	8	be	be	VB
cord-336510-qzm9wgde	437	9	the	the	DT
cord-336510-qzm9wgde	437	10	cell	cell	NN
cord-336510-qzm9wgde	437	11	type	type	NN
cord-336510-qzm9wgde	437	12	responding	respond	VBG
cord-336510-qzm9wgde	437	13	with	with	IN
cord-336510-qzm9wgde	437	14	an	an	DT
cord-336510-qzm9wgde	437	15	oxidative	oxidative	JJ
cord-336510-qzm9wgde	437	16	burst	burst	NN
cord-336510-qzm9wgde	437	17	,	,	,
cord-336510-qzm9wgde	437	18	and	and	CC
cord-336510-qzm9wgde	437	19	this	this	DT
cord-336510-qzm9wgde	437	20	capacity	capacity	NN
cord-336510-qzm9wgde	437	21	peaked	peak	VBD
cord-336510-qzm9wgde	437	22	after	after	IN
cord-336510-qzm9wgde	437	23	only	only	RB
cord-336510-qzm9wgde	437	24	8	8	CD
cord-336510-qzm9wgde	437	25	hours	hour	NNS
cord-336510-qzm9wgde	437	26	of	of	IN
cord-336510-qzm9wgde	437	27	infection	infection	NN
cord-336510-qzm9wgde	437	28	with	with	IN
cord-336510-qzm9wgde	437	29	HSV	HSV	NNP
cord-336510-qzm9wgde	437	30	[	[	-LRB-
cord-336510-qzm9wgde	437	31	353	353	CD
cord-336510-qzm9wgde	437	32	]	]	-RRB-
cord-336510-qzm9wgde	437	33	.	.	.
cord-336510-qzm9wgde	438	1	This	this	DT
cord-336510-qzm9wgde	438	2	HSV	HSV	NNP
cord-336510-qzm9wgde	438	3	-	-	HYPH
cord-336510-qzm9wgde	438	4	induced	induce	VBN
cord-336510-qzm9wgde	438	5	capacity	capacity	NN
cord-336510-qzm9wgde	438	6	for	for	IN
cord-336510-qzm9wgde	438	7	an	an	DT
cord-336510-qzm9wgde	438	8	increased	increase	VBN
cord-336510-qzm9wgde	438	9	respiratory	respiratory	JJ
cord-336510-qzm9wgde	438	10	burst	burst	NN
cord-336510-qzm9wgde	438	11	was	be	VBD
cord-336510-qzm9wgde	438	12	shown	show	VBN
cord-336510-qzm9wgde	438	13	to	to	TO
cord-336510-qzm9wgde	438	14	be	be	VB
cord-336510-qzm9wgde	438	15	governed	govern	VBN
cord-336510-qzm9wgde	438	16	by	by	IN
cord-336510-qzm9wgde	438	17	autocrine	autocrine	NN
cord-336510-qzm9wgde	438	18	IFN	IFN	NNP
cord-336510-qzm9wgde	438	19	-	-	HYPH
cord-336510-qzm9wgde	438	20	α	α	NNP
cord-336510-qzm9wgde	438	21	/	/	SYM
cord-336510-qzm9wgde	438	22	β	β	NN
cord-336510-qzm9wgde	438	23	as	as	IN
cord-336510-qzm9wgde	438	24	a	a	DT
cord-336510-qzm9wgde	438	25	sine	sine	FW
cord-336510-qzm9wgde	438	26	qua	qua	FW
cord-336510-qzm9wgde	438	27	non	non	FW
cord-336510-qzm9wgde	438	28	phenomenon	phenomenon	NN
cord-336510-qzm9wgde	438	29	[	[	-LRB-
cord-336510-qzm9wgde	438	30	300	300	CD
cord-336510-qzm9wgde	438	31	,	,	,
cord-336510-qzm9wgde	438	32	353	353	CD
cord-336510-qzm9wgde	438	33	]	]	-RRB-
cord-336510-qzm9wgde	438	34	.	.	.
cord-336510-qzm9wgde	439	1	Nevertheless	nevertheless	RB
cord-336510-qzm9wgde	439	2	,	,	,
cord-336510-qzm9wgde	439	3	TNF	TNF	NNP
cord-336510-qzm9wgde	439	4	was	be	VBD
cord-336510-qzm9wgde	439	5	also	also	RB
cord-336510-qzm9wgde	439	6	found	find	VBN
cord-336510-qzm9wgde	439	7	to	to	TO
cord-336510-qzm9wgde	439	8	influence	influence	VB
cord-336510-qzm9wgde	439	9	the	the	DT
cord-336510-qzm9wgde	439	10	macrophage	macrophage	NN
cord-336510-qzm9wgde	439	11	activation	activation	NN
cord-336510-qzm9wgde	439	12	.	.	.
cord-336510-qzm9wgde	440	1	By	by	IN
cord-336510-qzm9wgde	440	2	itself	-PRON-	PRP
cord-336510-qzm9wgde	440	3	,	,	,
cord-336510-qzm9wgde	440	4	TNF	TNF	NNP
cord-336510-qzm9wgde	440	5	reduced	reduce	VBD
cord-336510-qzm9wgde	440	6	the	the	DT
cord-336510-qzm9wgde	440	7	macrophage	macrophage	NN
cord-336510-qzm9wgde	440	8	capacity	capacity	NN
cord-336510-qzm9wgde	440	9	for	for	IN
cord-336510-qzm9wgde	440	10	a	a	DT
cord-336510-qzm9wgde	440	11	respiratory	respiratory	JJ
cord-336510-qzm9wgde	440	12	burst	burst	NN
cord-336510-qzm9wgde	440	13	,	,	,
cord-336510-qzm9wgde	440	14	but	but	CC
cord-336510-qzm9wgde	440	15	in	in	IN
cord-336510-qzm9wgde	440	16	combination	combination	NN
cord-336510-qzm9wgde	440	17	with	with	IN
cord-336510-qzm9wgde	440	18	IFN	IFN	NNP
cord-336510-qzm9wgde	440	19	-	-	HYPH
cord-336510-qzm9wgde	440	20	α	α	NNP
cord-336510-qzm9wgde	440	21	/	/	SYM
cord-336510-qzm9wgde	440	22	β	β	NN
cord-336510-qzm9wgde	440	23	it	-PRON-	PRP
cord-336510-qzm9wgde	440	24	synergistically	synergistically	RB
cord-336510-qzm9wgde	440	25	enhanced	enhance	VBD
cord-336510-qzm9wgde	440	26	the	the	DT
cord-336510-qzm9wgde	440	27	IFN	IFN	NNP
cord-336510-qzm9wgde	440	28	-	-	HYPH
cord-336510-qzm9wgde	440	29	induced	induce	VBN
cord-336510-qzm9wgde	440	30	activation	activation	NN
cord-336510-qzm9wgde	440	31	[	[	-LRB-
cord-336510-qzm9wgde	440	32	293	293	CD
cord-336510-qzm9wgde	440	33	,	,	,
cord-336510-qzm9wgde	440	34	300	300	CD
cord-336510-qzm9wgde	440	35	]	]	-RRB-
cord-336510-qzm9wgde	440	36	.	.	.
cord-336510-qzm9wgde	441	1	Interestingly	interestingly	RB
cord-336510-qzm9wgde	441	2	,	,	,
cord-336510-qzm9wgde	441	3	a	a	DT
cord-336510-qzm9wgde	441	4	secreted	secrete	VBN
cord-336510-qzm9wgde	441	5	portion	portion	NN
cord-336510-qzm9wgde	441	6	of	of	IN
cord-336510-qzm9wgde	441	7	the	the	DT
cord-336510-qzm9wgde	441	8	HSV	HSV	NNP
cord-336510-qzm9wgde	441	9	-	-	HYPH
cord-336510-qzm9wgde	441	10	gG	gG	NNP
cord-336510-qzm9wgde	441	11	acts	act	VBZ
cord-336510-qzm9wgde	441	12	as	as	IN
cord-336510-qzm9wgde	441	13	a	a	DT
cord-336510-qzm9wgde	441	14	phagocyte	phagocyte	NNP
cord-336510-qzm9wgde	441	15	chemoattractant	chemoattractant	NN
cord-336510-qzm9wgde	441	16	and	and	CC
cord-336510-qzm9wgde	441	17	induces	induce	VBZ
cord-336510-qzm9wgde	441	18	production	production	NN
cord-336510-qzm9wgde	441	19	of	of	IN
cord-336510-qzm9wgde	441	20	ROS	ROS	NNP
cord-336510-qzm9wgde	441	21	by	by	IN
cord-336510-qzm9wgde	441	22	signalling	signal	VBG
cord-336510-qzm9wgde	441	23	through	through	IN
cord-336510-qzm9wgde	441	24	the	the	DT
cord-336510-qzm9wgde	441	25	receptor	receptor	NN
cord-336510-qzm9wgde	441	26	activated	activate	VBN
cord-336510-qzm9wgde	441	27	by	by	IN
cord-336510-qzm9wgde	441	28	the	the	DT
cord-336510-qzm9wgde	441	29	phorbol	phorbol	NNP
cord-336510-qzm9wgde	441	30	esters	esters	NNP
cord-336510-qzm9wgde	441	31	[	[	-LRB-
cord-336510-qzm9wgde	441	32	354	354	CD
cord-336510-qzm9wgde	441	33	]	]	-RRB-
cord-336510-qzm9wgde	441	34	.	.	.
cord-336510-qzm9wgde	442	1	The	the	DT
cord-336510-qzm9wgde	442	2	HSV	HSV	NNP
cord-336510-qzm9wgde	442	3	-	-	HYPH
cord-336510-qzm9wgde	442	4	induced	induce	VBN
cord-336510-qzm9wgde	442	5	activation	activation	NN
cord-336510-qzm9wgde	442	6	of	of	IN
cord-336510-qzm9wgde	442	7	macrophages	macrophage	NNS
cord-336510-qzm9wgde	442	8	in	in	IN
cord-336510-qzm9wgde	442	9	vivo	vivo	NNP
cord-336510-qzm9wgde	442	10	is	be	VBZ
cord-336510-qzm9wgde	442	11	influenced	influence	VBN
cord-336510-qzm9wgde	442	12	by	by	IN
cord-336510-qzm9wgde	442	13	the	the	DT
cord-336510-qzm9wgde	442	14	genetic	genetic	JJ
cord-336510-qzm9wgde	442	15	constitution	constitution	NN
cord-336510-qzm9wgde	442	16	of	of	IN
cord-336510-qzm9wgde	442	17	the	the	DT
cord-336510-qzm9wgde	442	18	host	host	NN
cord-336510-qzm9wgde	442	19	,	,	,
cord-336510-qzm9wgde	442	20	with	with	IN
cord-336510-qzm9wgde	442	21	the	the	DT
cord-336510-qzm9wgde	442	22	most	most	RBS
cord-336510-qzm9wgde	442	23	pronounced	pronounced	JJ
cord-336510-qzm9wgde	442	24	activation	activation	NN
cord-336510-qzm9wgde	442	25	of	of	IN
cord-336510-qzm9wgde	442	26	macrophages	macrophage	NNS
cord-336510-qzm9wgde	442	27	originating	originate	VBG
cord-336510-qzm9wgde	442	28	from	from	IN
cord-336510-qzm9wgde	442	29	resistant	resistant	JJ
cord-336510-qzm9wgde	442	30	mice	mouse	NNS
cord-336510-qzm9wgde	442	31	,	,	,
cord-336510-qzm9wgde	442	32	as	as	IN
cord-336510-qzm9wgde	442	33	expected	expect	VBN
cord-336510-qzm9wgde	442	34	on	on	IN
cord-336510-qzm9wgde	442	35	the	the	DT
cord-336510-qzm9wgde	442	36	basis	basis	NN
cord-336510-qzm9wgde	442	37	of	of	IN
cord-336510-qzm9wgde	442	38	the	the	DT
cord-336510-qzm9wgde	442	39	genetics	genetic	NNS
cord-336510-qzm9wgde	442	40	of	of	IN
cord-336510-qzm9wgde	442	41	IFN	IFN	NNP
cord-336510-qzm9wgde	442	42	-	-	HYPH
cord-336510-qzm9wgde	442	43	α	α	NNP
cord-336510-qzm9wgde	442	44	/	/	SYM
cord-336510-qzm9wgde	442	45	β	β	NN
cord-336510-qzm9wgde	442	46	production	production	NN
cord-336510-qzm9wgde	442	47	in	in	IN
cord-336510-qzm9wgde	442	48	response	response	NN
cord-336510-qzm9wgde	442	49	to	to	IN
cord-336510-qzm9wgde	442	50	the	the	DT
cord-336510-qzm9wgde	442	51	infection	infection	NN
cord-336510-qzm9wgde	442	52	.	.	.
cord-336510-qzm9wgde	443	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	443	2	,	,	,
cord-336510-qzm9wgde	443	3	the	the	DT
cord-336510-qzm9wgde	443	4	genetics	genetic	NNS
cord-336510-qzm9wgde	443	5	of	of	IN
cord-336510-qzm9wgde	443	6	the	the	DT
cord-336510-qzm9wgde	443	7	efferent	efferent	JJ
cord-336510-qzm9wgde	443	8	part	part	NN
cord-336510-qzm9wgde	443	9	of	of	IN
cord-336510-qzm9wgde	443	10	the	the	DT
cord-336510-qzm9wgde	443	11	IFN	IFN	NNP
cord-336510-qzm9wgde	443	12	-	-	HYPH
cord-336510-qzm9wgde	443	13	α	α	NNP
cord-336510-qzm9wgde	443	14	/	/	SYM
cord-336510-qzm9wgde	443	15	β	β	NN
cord-336510-qzm9wgde	443	16	-	-	HYPH
cord-336510-qzm9wgde	443	17	mediated	mediate	VBN
cord-336510-qzm9wgde	443	18	HSV	HSV	NNP
cord-336510-qzm9wgde	443	19	-	-	HYPH
cord-336510-qzm9wgde	443	20	induced	induce	VBN
cord-336510-qzm9wgde	443	21	activation	activation	NN
cord-336510-qzm9wgde	443	22	of	of	IN
cord-336510-qzm9wgde	443	23	macrophages	macrophage	NNS
cord-336510-qzm9wgde	443	24	,	,	,
cord-336510-qzm9wgde	443	25	displayed	display	VBD
cord-336510-qzm9wgde	443	26	a	a	DT
cord-336510-qzm9wgde	443	27	co	co	JJ
cord-336510-qzm9wgde	443	28	-	-	JJ
cord-336510-qzm9wgde	443	29	dominant	dominant	JJ
cord-336510-qzm9wgde	443	30	autosomal	autosomal	JJ
cord-336510-qzm9wgde	443	31	trait	trait	NN
cord-336510-qzm9wgde	443	32	,	,	,
cord-336510-qzm9wgde	443	33	as	as	IN
cord-336510-qzm9wgde	443	34	was	be	VBD
cord-336510-qzm9wgde	443	35	the	the	DT
cord-336510-qzm9wgde	443	36	case	case	NN
cord-336510-qzm9wgde	443	37	with	with	IN
cord-336510-qzm9wgde	443	38	the	the	DT
cord-336510-qzm9wgde	443	39	antiviral	antiviral	JJ
cord-336510-qzm9wgde	443	40	effect	effect	NN
cord-336510-qzm9wgde	443	41	of	of	IN
cord-336510-qzm9wgde	443	42	IFN	IFN	NNP
cord-336510-qzm9wgde	443	43	-	-	HYPH
cord-336510-qzm9wgde	443	44	α	α	NNP
cord-336510-qzm9wgde	443	45	/	/	SYM
cord-336510-qzm9wgde	443	46	β	β	NN
cord-336510-qzm9wgde	443	47	in	in	IN
cord-336510-qzm9wgde	443	48	fibroblasts	fibroblast	NNS
cord-336510-qzm9wgde	443	49	[	[	-LRB-
cord-336510-qzm9wgde	443	50	336	336	CD
cord-336510-qzm9wgde	443	51	]	]	-RRB-
cord-336510-qzm9wgde	443	52	.	.	.
cord-336510-qzm9wgde	444	1	Thus	thus	RB
cord-336510-qzm9wgde	444	2	,	,	,
cord-336510-qzm9wgde	444	3	the	the	DT
cord-336510-qzm9wgde	444	4	genetically	genetically	RB
cord-336510-qzm9wgde	444	5	-	-	HYPH
cord-336510-qzm9wgde	444	6	determined	determine	VBN
cord-336510-qzm9wgde	444	7	sensitivity	sensitivity	NN
cord-336510-qzm9wgde	444	8	to	to	IN
cord-336510-qzm9wgde	444	9	IFNα/	ifnα/	NN
cord-336510-qzm9wgde	445	1	β	β	NNP
cord-336510-qzm9wgde	445	2	seems	seem	VBZ
cord-336510-qzm9wgde	445	3	to	to	TO
cord-336510-qzm9wgde	445	4	be	be	VB
cord-336510-qzm9wgde	445	5	expressed	express	VBN
cord-336510-qzm9wgde	445	6	in	in	IN
cord-336510-qzm9wgde	445	7	different	different	JJ
cord-336510-qzm9wgde	445	8	cell	cell	NN
cord-336510-qzm9wgde	445	9	-	-	HYPH
cord-336510-qzm9wgde	445	10	types	type	NNS
cord-336510-qzm9wgde	445	11	.	.	.
cord-336510-qzm9wgde	446	1	The	the	DT
cord-336510-qzm9wgde	446	2	influence	influence	NN
cord-336510-qzm9wgde	446	3	of	of	IN
cord-336510-qzm9wgde	446	4	TNF	TNF	NNP
cord-336510-qzm9wgde	446	5	on	on	IN
cord-336510-qzm9wgde	446	6	the	the	DT
cord-336510-qzm9wgde	446	7	genetics	genetic	NNS
cord-336510-qzm9wgde	446	8	of	of	IN
cord-336510-qzm9wgde	446	9	this	this	DT
cord-336510-qzm9wgde	446	10	phenomenon	phenomenon	NN
cord-336510-qzm9wgde	446	11	has	have	VBZ
cord-336510-qzm9wgde	446	12	not	not	RB
cord-336510-qzm9wgde	446	13	been	be	VBN
cord-336510-qzm9wgde	446	14	addressed	address	VBN
cord-336510-qzm9wgde	446	15	.	.	.
cord-336510-qzm9wgde	447	1	In	in	IN
cord-336510-qzm9wgde	447	2	Contrast	contrast	NN
cord-336510-qzm9wgde	447	3	to	to	IN
cord-336510-qzm9wgde	447	4	these	these	DT
cord-336510-qzm9wgde	447	5	observations	observation	NNS
cord-336510-qzm9wgde	447	6	,	,	,
cord-336510-qzm9wgde	447	7	the	the	DT
cord-336510-qzm9wgde	447	8	genetics	genetic	NNS
cord-336510-qzm9wgde	447	9	concerning	concern	VBG
cord-336510-qzm9wgde	447	10	the	the	DT
cord-336510-qzm9wgde	447	11	antiproliferative	antiproliferative	JJ
cord-336510-qzm9wgde	447	12	effect	effect	NN
cord-336510-qzm9wgde	447	13	of	of	IN
cord-336510-qzm9wgde	447	14	IFN	IFN	NNP
cord-336510-qzm9wgde	447	15	-	-	HYPH
cord-336510-qzm9wgde	447	16	α	α	NNP
cord-336510-qzm9wgde	447	17	/	/	SYM
cord-336510-qzm9wgde	447	18	β	β	NN
cord-336510-qzm9wgde	447	19	in	in	IN
cord-336510-qzm9wgde	447	20	bone	bone	NN
cord-336510-qzm9wgde	447	21	marrow	marrow	NN
cord-336510-qzm9wgde	447	22	cells	cell	NNS
cord-336510-qzm9wgde	447	23	seems	seem	VBZ
cord-336510-qzm9wgde	447	24	to	to	TO
cord-336510-qzm9wgde	447	25	be	be	VB
cord-336510-qzm9wgde	447	26	reversed	reverse	VBN
cord-336510-qzm9wgde	447	27	[	[	-LRB-
cord-336510-qzm9wgde	447	28	335	335	CD
cord-336510-qzm9wgde	447	29	,	,	,
cord-336510-qzm9wgde	447	30	355	355	CD
cord-336510-qzm9wgde	447	31	]	]	-RRB-
cord-336510-qzm9wgde	447	32	.	.	.
cord-336510-qzm9wgde	448	1	This	this	DT
cord-336510-qzm9wgde	448	2	might	may	MD
cord-336510-qzm9wgde	448	3	,	,	,
cord-336510-qzm9wgde	448	4	however	however	RB
cord-336510-qzm9wgde	448	5	,	,	,
cord-336510-qzm9wgde	448	6	be	be	VB
cord-336510-qzm9wgde	448	7	linked	link	VBN
cord-336510-qzm9wgde	448	8	,	,	,
cord-336510-qzm9wgde	448	9	in	in	IN
cord-336510-qzm9wgde	448	10	that	that	DT
cord-336510-qzm9wgde	448	11	ROS	ROS	NNP
cord-336510-qzm9wgde	448	12	are	be	VBP
cord-336510-qzm9wgde	448	13	shown	show	VBN
cord-336510-qzm9wgde	448	14	to	to	TO
cord-336510-qzm9wgde	448	15	activate	activate	VB
cord-336510-qzm9wgde	448	16	various	various	JJ
cord-336510-qzm9wgde	448	17	signalling	signal	VBG
cord-336510-qzm9wgde	448	18	molecules	molecule	NNS
cord-336510-qzm9wgde	448	19	,	,	,
cord-336510-qzm9wgde	448	20	mediate	mediate	VB
cord-336510-qzm9wgde	448	21	apoptosis	apoptosis	NN
cord-336510-qzm9wgde	448	22	,	,	,
cord-336510-qzm9wgde	448	23	and	and	CC
cord-336510-qzm9wgde	448	24	exhibit	exhibit	VB
cord-336510-qzm9wgde	448	25	antiproliferative	antiproliferative	JJ
cord-336510-qzm9wgde	448	26	effects	effect	NNS
cord-336510-qzm9wgde	448	27	depending	depend	VBG
cord-336510-qzm9wgde	448	28	on	on	IN
cord-336510-qzm9wgde	448	29	the	the	DT
cord-336510-qzm9wgde	448	30	dose	dose	NN
cord-336510-qzm9wgde	448	31	and	and	CC
cord-336510-qzm9wgde	448	32	time	time	NN
cord-336510-qzm9wgde	448	33	of	of	IN
cord-336510-qzm9wgde	448	34	exposure	exposure	NN
cord-336510-qzm9wgde	448	35	[	[	-LRB-
cord-336510-qzm9wgde	448	36	352	352	CD
cord-336510-qzm9wgde	448	37	]	]	-RRB-
cord-336510-qzm9wgde	448	38	.	.	.
cord-336510-qzm9wgde	449	1	Little	little	JJ
cord-336510-qzm9wgde	449	2	is	be	VBZ
cord-336510-qzm9wgde	449	3	known	know	VBN
cord-336510-qzm9wgde	449	4	on	on	IN
cord-336510-qzm9wgde	449	5	the	the	DT
cord-336510-qzm9wgde	449	6	potential	potential	JJ
cord-336510-qzm9wgde	449	7	antiviral	antiviral	JJ
cord-336510-qzm9wgde	449	8	effect	effect	NN
cord-336510-qzm9wgde	449	9	of	of	IN
cord-336510-qzm9wgde	449	10	ROS	ROS	NNP
cord-336510-qzm9wgde	449	11	.	.	.
cord-336510-qzm9wgde	450	1	By	by	IN
cord-336510-qzm9wgde	450	2	examining	examine	VBG
cord-336510-qzm9wgde	450	3	peroxidized	peroxidized	JJ
cord-336510-qzm9wgde	450	4	lipids	lipid	NNS
cord-336510-qzm9wgde	450	5	,	,	,
cord-336510-qzm9wgde	450	6	which	which	WDT
cord-336510-qzm9wgde	450	7	is	be	VBZ
cord-336510-qzm9wgde	450	8	an	an	DT
cord-336510-qzm9wgde	450	9	oxidative	oxidative	JJ
cord-336510-qzm9wgde	450	10	product	product	NN
cord-336510-qzm9wgde	450	11	from	from	IN
cord-336510-qzm9wgde	450	12	ROS	ROS	NNP
cord-336510-qzm9wgde	450	13	in	in	IN
cord-336510-qzm9wgde	450	14	tissues	tissue	NNS
cord-336510-qzm9wgde	450	15	,	,	,
cord-336510-qzm9wgde	450	16	it	-PRON-	PRP
cord-336510-qzm9wgde	450	17	has	have	VBZ
cord-336510-qzm9wgde	450	18	been	be	VBN
cord-336510-qzm9wgde	450	19	documented	document	VBN
cord-336510-qzm9wgde	450	20	that	that	IN
cord-336510-qzm9wgde	450	21	these	these	DT
cord-336510-qzm9wgde	450	22	are	be	VBP
cord-336510-qzm9wgde	450	23	produced	produce	VBN
cord-336510-qzm9wgde	450	24	during	during	IN
cord-336510-qzm9wgde	450	25	the	the	DT
cord-336510-qzm9wgde	450	26	acute	acute	JJ
cord-336510-qzm9wgde	450	27	HSV	HSV	NNP
cord-336510-qzm9wgde	450	28	infection	infection	NN
cord-336510-qzm9wgde	450	29	in	in	IN
cord-336510-qzm9wgde	450	30	vivo	vivo	NN
cord-336510-qzm9wgde	450	31	,	,	,
cord-336510-qzm9wgde	450	32	and	and	CC
cord-336510-qzm9wgde	450	33	speculations	speculation	NNS
cord-336510-qzm9wgde	450	34	on	on	IN
cord-336510-qzm9wgde	450	35	antiviral	antiviral	JJ
cord-336510-qzm9wgde	450	36	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	450	37	have	have	VBP
cord-336510-qzm9wgde	450	38	focused	focus	VBN
cord-336510-qzm9wgde	450	39	on	on	IN
cord-336510-qzm9wgde	450	40	induction	induction	NN
cord-336510-qzm9wgde	450	41	of	of	IN
cord-336510-qzm9wgde	450	42	apoptosis	apoptosis	NN
cord-336510-qzm9wgde	450	43	[	[	-LRB-
cord-336510-qzm9wgde	450	44	348	348	CD
cord-336510-qzm9wgde	450	45	,	,	,
cord-336510-qzm9wgde	450	46	356	356	CD
cord-336510-qzm9wgde	450	47	,	,	,
cord-336510-qzm9wgde	450	48	357	357	CD
cord-336510-qzm9wgde	450	49	]	]	-RRB-
cord-336510-qzm9wgde	450	50	.	.	.
cord-336510-qzm9wgde	451	1	HSV	HSV	NNP
cord-336510-qzm9wgde	451	2	triggers	trigger	VBZ
cord-336510-qzm9wgde	451	3	apoptosis	apoptosis	NN
cord-336510-qzm9wgde	451	4	of	of	IN
cord-336510-qzm9wgde	451	5	infected	infected	JJ
cord-336510-qzm9wgde	451	6	cells	cell	NNS
cord-336510-qzm9wgde	451	7	by	by	IN
cord-336510-qzm9wgde	451	8	several	several	JJ
cord-336510-qzm9wgde	451	9	pathways	pathway	NNS
cord-336510-qzm9wgde	451	10	,	,	,
cord-336510-qzm9wgde	451	11	and	and	CC
cord-336510-qzm9wgde	451	12	the	the	DT
cord-336510-qzm9wgde	451	13	importance	importance	NN
cord-336510-qzm9wgde	451	14	of	of	IN
cord-336510-qzm9wgde	451	15	this	this	DT
cord-336510-qzm9wgde	451	16	phenomenon	phenomenon	NN
cord-336510-qzm9wgde	451	17	is	be	VBZ
cord-336510-qzm9wgde	451	18	indicated	indicate	VBN
cord-336510-qzm9wgde	451	19	by	by	IN
cord-336510-qzm9wgde	451	20	the	the	DT
cord-336510-qzm9wgde	451	21	fact	fact	NN
cord-336510-qzm9wgde	451	22	that	that	IN
cord-336510-qzm9wgde	451	23	the	the	DT
cord-336510-qzm9wgde	451	24	virus	virus	NN
cord-336510-qzm9wgde	451	25	has	have	VBZ
cord-336510-qzm9wgde	451	26	evolved	evolve	VBN
cord-336510-qzm9wgde	451	27	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	451	28	to	to	TO
cord-336510-qzm9wgde	451	29	counteract	counteract	VB
cord-336510-qzm9wgde	451	30	each	each	DT
cord-336510-qzm9wgde	451	31	of	of	IN
cord-336510-qzm9wgde	451	32	these	these	DT
cord-336510-qzm9wgde	451	33	pathways	pathway	NNS
cord-336510-qzm9wgde	451	34	[	[	-LRB-
cord-336510-qzm9wgde	451	35	358	358	CD
cord-336510-qzm9wgde	451	36	]	]	-RRB-
cord-336510-qzm9wgde	451	37	.	.	.
cord-336510-qzm9wgde	452	1	Macrophages	macrophage	NNS
cord-336510-qzm9wgde	452	2	generally	generally	RB
cord-336510-qzm9wgde	452	3	suppress	suppress	VBP
cord-336510-qzm9wgde	452	4	apoptosis	apoptosis	NN
cord-336510-qzm9wgde	452	5	in	in	IN
cord-336510-qzm9wgde	452	6	HSV	HSV	NNP
cord-336510-qzm9wgde	452	7	infections	infection	NNS
cord-336510-qzm9wgde	452	8	,	,	,
cord-336510-qzm9wgde	452	9	as	as	IN
cord-336510-qzm9wgde	452	10	seen	see	VBN
cord-336510-qzm9wgde	452	11	by	by	IN
cord-336510-qzm9wgde	452	12	increased	increase	VBN
cord-336510-qzm9wgde	452	13	apoptosis	apoptosis	NN
cord-336510-qzm9wgde	452	14	in	in	IN
cord-336510-qzm9wgde	452	15	macrophage	macrophage	NN
cord-336510-qzm9wgde	452	16	-	-	HYPH
cord-336510-qzm9wgde	452	17	depleted	deplete	VBN
cord-336510-qzm9wgde	452	18	mice	mouse	NNS
cord-336510-qzm9wgde	452	19	[	[	-LRB-
cord-336510-qzm9wgde	452	20	359	359	CD
cord-336510-qzm9wgde	452	21	]	]	-RRB-
cord-336510-qzm9wgde	452	22	.	.	.
cord-336510-qzm9wgde	453	1	Several	several	JJ
cord-336510-qzm9wgde	453	2	studies	study	NNS
cord-336510-qzm9wgde	453	3	on	on	IN
cord-336510-qzm9wgde	453	4	the	the	DT
cord-336510-qzm9wgde	453	5	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	453	6	involved	involve	VBN
cord-336510-qzm9wgde	453	7	in	in	IN
cord-336510-qzm9wgde	453	8	the	the	DT
cord-336510-qzm9wgde	453	9	early	early	JJ
cord-336510-qzm9wgde	453	10	battle	battle	NN
cord-336510-qzm9wgde	453	11	against	against	IN
cord-336510-qzm9wgde	453	12	HSV	HSV	NNP
cord-336510-qzm9wgde	453	13	,	,	,
cord-336510-qzm9wgde	453	14	performed	perform	VBN
cord-336510-qzm9wgde	453	15	in	in	RB
cord-336510-qzm9wgde	453	16	in	in	IN
cord-336510-qzm9wgde	453	17	vivo	vivo	NN
cord-336510-qzm9wgde	453	18	animal	animal	NN
cord-336510-qzm9wgde	453	19	models	model	NNS
cord-336510-qzm9wgde	453	20	,	,	,
cord-336510-qzm9wgde	453	21	have	have	VBP
cord-336510-qzm9wgde	453	22	pointed	point	VBN
cord-336510-qzm9wgde	453	23	to	to	IN
cord-336510-qzm9wgde	453	24	IFN	IFN	NNP
cord-336510-qzm9wgde	453	25	-	-	HYPH
cord-336510-qzm9wgde	453	26	α	α	NNP
cord-336510-qzm9wgde	453	27	/	/	SYM
cord-336510-qzm9wgde	453	28	β	β	NN
cord-336510-qzm9wgde	453	29	as	as	IN
cord-336510-qzm9wgde	453	30	a	a	DT
cord-336510-qzm9wgde	453	31	crucial	crucial	JJ
cord-336510-qzm9wgde	453	32	player	player	NN
cord-336510-qzm9wgde	453	33	.	.	.
cord-336510-qzm9wgde	454	1	In	in	IN
cord-336510-qzm9wgde	454	2	adoptive	adoptive	JJ
cord-336510-qzm9wgde	454	3	transfer	transfer	NN
cord-336510-qzm9wgde	454	4	experiments	experiment	NNS
cord-336510-qzm9wgde	454	5	,	,	,
cord-336510-qzm9wgde	454	6	the	the	DT
cord-336510-qzm9wgde	454	7	effect	effect	NN
cord-336510-qzm9wgde	454	8	of	of	IN
cord-336510-qzm9wgde	454	9	adult	adult	NN
cord-336510-qzm9wgde	454	10	mouse	mouse	NN
cord-336510-qzm9wgde	454	11	spleen	spleen	NN
cord-336510-qzm9wgde	454	12	cells	cell	NNS
cord-336510-qzm9wgde	454	13	on	on	IN
cord-336510-qzm9wgde	454	14	the	the	DT
cord-336510-qzm9wgde	454	15	initial	initial	JJ
cord-336510-qzm9wgde	454	16	phase	phase	NN
cord-336510-qzm9wgde	454	17	of	of	IN
cord-336510-qzm9wgde	454	18	a	a	DT
cord-336510-qzm9wgde	454	19	generalized	generalized	JJ
cord-336510-qzm9wgde	454	20	HSV	HSV	NNP
cord-336510-qzm9wgde	454	21	infection	infection	NN
cord-336510-qzm9wgde	454	22	in	in	IN
cord-336510-qzm9wgde	454	23	suckling	suckle	VBG
cord-336510-qzm9wgde	454	24	mice	mouse	NNS
cord-336510-qzm9wgde	454	25	was	be	VBD
cord-336510-qzm9wgde	454	26	conducted	conduct	VBN
cord-336510-qzm9wgde	454	27	by	by	IN
cord-336510-qzm9wgde	454	28	IFN	IFN	NNP
cord-336510-qzm9wgde	454	29	-	-	HYPH
cord-336510-qzm9wgde	454	30	α	α	NNP
cord-336510-qzm9wgde	454	31	/	/	SYM
cord-336510-qzm9wgde	454	32	β	β	NN
cord-336510-qzm9wgde	454	33	[	[	-LRB-
cord-336510-qzm9wgde	454	34	360	360	CD
cord-336510-qzm9wgde	454	35	]	]	-RRB-
cord-336510-qzm9wgde	454	36	.	.	.
cord-336510-qzm9wgde	455	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	455	2	,	,	,
cord-336510-qzm9wgde	455	3	administration	administration	NN
cord-336510-qzm9wgde	455	4	of	of	IN
cord-336510-qzm9wgde	455	5	a	a	DT
cord-336510-qzm9wgde	455	6	hematopoetic	hematopoetic	JJ
cord-336510-qzm9wgde	455	7	growth	growth	NN
cord-336510-qzm9wgde	455	8	factor	factor	NN
cord-336510-qzm9wgde	455	9	to	to	IN
cord-336510-qzm9wgde	455	10	neonatal	neonatal	JJ
cord-336510-qzm9wgde	455	11	mice	mice	NN
cord-336510-qzm9wgde	455	12	increases	increase	VBZ
cord-336510-qzm9wgde	455	13	the	the	DT
cord-336510-qzm9wgde	455	14	number	number	NN
cord-336510-qzm9wgde	455	15	of	of	IN
cord-336510-qzm9wgde	455	16	dendritic	dendritic	JJ
cord-336510-qzm9wgde	455	17	cells	cell	NNS
cord-336510-qzm9wgde	455	18	,	,	,
cord-336510-qzm9wgde	455	19	B	b	NN
cord-336510-qzm9wgde	455	20	cells	cell	NNS
cord-336510-qzm9wgde	455	21	and	and	CC
cord-336510-qzm9wgde	455	22	NK	NK	NNP
cord-336510-qzm9wgde	455	23	cells	cell	NNS
cord-336510-qzm9wgde	455	24	,	,	,
cord-336510-qzm9wgde	455	25	and	and	CC
cord-336510-qzm9wgde	455	26	confers	confer	VBZ
cord-336510-qzm9wgde	455	27	resistance	resistance	NN
cord-336510-qzm9wgde	455	28	in	in	IN
cord-336510-qzm9wgde	455	29	a	a	DT
cord-336510-qzm9wgde	455	30	cutaneous	cutaneous	JJ
cord-336510-qzm9wgde	455	31	model	model	NN
cord-336510-qzm9wgde	455	32	of	of	IN
cord-336510-qzm9wgde	455	33	HSV	HSV	NNP
cord-336510-qzm9wgde	455	34	infection	infection	NN
cord-336510-qzm9wgde	455	35	.	.	.
cord-336510-qzm9wgde	456	1	The	the	DT
cord-336510-qzm9wgde	456	2	effect	effect	NN
cord-336510-qzm9wgde	456	3	in	in	IN
cord-336510-qzm9wgde	456	4	this	this	DT
cord-336510-qzm9wgde	456	5	model	model	NN
cord-336510-qzm9wgde	456	6	could	could	MD
cord-336510-qzm9wgde	456	7	also	also	RB
cord-336510-qzm9wgde	456	8	largely	largely	RB
cord-336510-qzm9wgde	456	9	be	be	VB
cord-336510-qzm9wgde	456	10	attributed	attribute	VBN
cord-336510-qzm9wgde	456	11	to	to	IN
cord-336510-qzm9wgde	456	12	the	the	DT
cord-336510-qzm9wgde	456	13	actions	action	NNS
cord-336510-qzm9wgde	456	14	of	of	IN
cord-336510-qzm9wgde	456	15	IFN	IFN	NNP
cord-336510-qzm9wgde	456	16	-	-	HYPH
cord-336510-qzm9wgde	456	17	α	α	NNP
cord-336510-qzm9wgde	456	18	/	/	SYM
cord-336510-qzm9wgde	456	19	β	β	NN
cord-336510-qzm9wgde	456	20	,	,	,
cord-336510-qzm9wgde	456	21	with	with	IN
cord-336510-qzm9wgde	456	22	some	some	DT
cord-336510-qzm9wgde	456	23	additional	additional	JJ
cord-336510-qzm9wgde	456	24	contributions	contribution	NNS
cord-336510-qzm9wgde	456	25	by	by	IN
cord-336510-qzm9wgde	456	26	IFN	IFN	NNP
cord-336510-qzm9wgde	456	27	-	-	HYPH
cord-336510-qzm9wgde	456	28	γ	γ	NNP
cord-336510-qzm9wgde	456	29	[	[	-LRB-
cord-336510-qzm9wgde	456	30	361	361	CD
cord-336510-qzm9wgde	456	31	,	,	,
cord-336510-qzm9wgde	456	32	362	362	CD
cord-336510-qzm9wgde	456	33	]	]	-RRB-
cord-336510-qzm9wgde	456	34	.	.	.
cord-336510-qzm9wgde	457	1	In	in	IN
cord-336510-qzm9wgde	457	2	KO	KO	NNP
cord-336510-qzm9wgde	457	3	-	-	HYPH
cord-336510-qzm9wgde	457	4	mice	mice	NN
cord-336510-qzm9wgde	457	5	IFN	IFN	NNP
cord-336510-qzm9wgde	457	6	-	-	HYPH
cord-336510-qzm9wgde	457	7	α	α	NNP
cord-336510-qzm9wgde	457	8	/	/	SYM
cord-336510-qzm9wgde	457	9	β	β	NN
cord-336510-qzm9wgde	457	10	was	be	VBD
cord-336510-qzm9wgde	457	11	able	able	JJ
cord-336510-qzm9wgde	457	12	to	to	TO
cord-336510-qzm9wgde	457	13	control	control	VB
cord-336510-qzm9wgde	457	14	the	the	DT
cord-336510-qzm9wgde	457	15	initial	initial	JJ
cord-336510-qzm9wgde	457	16	phase	phase	NN
cord-336510-qzm9wgde	457	17	of	of	IN
cord-336510-qzm9wgde	457	18	a	a	DT
cord-336510-qzm9wgde	457	19	generalized	generalized	JJ
cord-336510-qzm9wgde	457	20	HSV	HSV	NNP
cord-336510-qzm9wgde	457	21	infection	infection	NN
cord-336510-qzm9wgde	457	22	without	without	IN
cord-336510-qzm9wgde	457	23	contributions	contribution	NNS
cord-336510-qzm9wgde	457	24	from	from	IN
cord-336510-qzm9wgde	457	25	NK	NK	NNP
cord-336510-qzm9wgde	457	26	,	,	,
cord-336510-qzm9wgde	457	27	T	T	NNP
cord-336510-qzm9wgde	457	28	-	-	HYPH
cord-336510-qzm9wgde	457	29	or	or	CC
cord-336510-qzm9wgde	457	30	B	b	NN
cord-336510-qzm9wgde	457	31	cells	cell	NNS
cord-336510-qzm9wgde	457	32	,	,	,
cord-336510-qzm9wgde	457	33	but	but	CC
cord-336510-qzm9wgde	457	34	these	these	DT
cord-336510-qzm9wgde	457	35	latter	latter	JJ
cord-336510-qzm9wgde	457	36	players	player	NNS
cord-336510-qzm9wgde	457	37	were	be	VBD
cord-336510-qzm9wgde	457	38	necessary	necessary	JJ
cord-336510-qzm9wgde	457	39	for	for	IN
cord-336510-qzm9wgde	457	40	survival	survival	NN
cord-336510-qzm9wgde	457	41	and	and	CC
cord-336510-qzm9wgde	457	42	long	long	JJ
cord-336510-qzm9wgde	457	43	term	term	NN
cord-336510-qzm9wgde	457	44	control	control	NN
cord-336510-qzm9wgde	457	45	of	of	IN
cord-336510-qzm9wgde	457	46	the	the	DT
cord-336510-qzm9wgde	457	47	infection	infection	NN
cord-336510-qzm9wgde	457	48	[	[	-LRB-
cord-336510-qzm9wgde	457	49	363	363	CD
cord-336510-qzm9wgde	457	50	]	]	-RRB-
cord-336510-qzm9wgde	457	51	.	.	.
cord-336510-qzm9wgde	458	1	The	the	DT
cord-336510-qzm9wgde	458	2	importance	importance	NN
cord-336510-qzm9wgde	458	3	of	of	IN
cord-336510-qzm9wgde	458	4	an	an	DT
cord-336510-qzm9wgde	458	5	early	early	JJ
cord-336510-qzm9wgde	458	6	,	,	,
cord-336510-qzm9wgde	458	7	local	local	JJ
cord-336510-qzm9wgde	458	8	IFN	IFN	NNP
cord-336510-qzm9wgde	458	9	-	-	HYPH
cord-336510-qzm9wgde	458	10	response	response	NN
cord-336510-qzm9wgde	458	11	in	in	IN
cord-336510-qzm9wgde	458	12	models	model	NNS
cord-336510-qzm9wgde	458	13	including	include	VBG
cord-336510-qzm9wgde	458	14	in	in	IN
cord-336510-qzm9wgde	458	15	vivo	vivo	NN
cord-336510-qzm9wgde	458	16	progression	progression	NN
cord-336510-qzm9wgde	458	17	and	and	CC
cord-336510-qzm9wgde	458	18	evaluation	evaluation	NN
cord-336510-qzm9wgde	458	19	of	of	IN
cord-336510-qzm9wgde	458	20	final	final	JJ
cord-336510-qzm9wgde	458	21	outcome	outcome	NN
cord-336510-qzm9wgde	458	22	of	of	IN
cord-336510-qzm9wgde	458	23	infection	infection	NN
cord-336510-qzm9wgde	458	24	is	be	VBZ
cord-336510-qzm9wgde	458	25	more	more	RBR
cord-336510-qzm9wgde	458	26	unclear	unclear	JJ
cord-336510-qzm9wgde	458	27	,	,	,
cord-336510-qzm9wgde	458	28	in	in	IN
cord-336510-qzm9wgde	458	29	that	that	DT
cord-336510-qzm9wgde	458	30	many	many	JJ
cord-336510-qzm9wgde	458	31	other	other	JJ
cord-336510-qzm9wgde	458	32	viral	viral	JJ
cord-336510-qzm9wgde	458	33	and	and	CC
cord-336510-qzm9wgde	458	34	host	host	NN
cord-336510-qzm9wgde	458	35	factors	factor	NNS
cord-336510-qzm9wgde	458	36	are	be	VBP
cord-336510-qzm9wgde	458	37	of	of	IN
cord-336510-qzm9wgde	458	38	importance	importance	NN
cord-336510-qzm9wgde	458	39	in	in	IN
cord-336510-qzm9wgde	458	40	these	these	DT
cord-336510-qzm9wgde	458	41	more	more	RBR
cord-336510-qzm9wgde	458	42	complicated	complicated	JJ
cord-336510-qzm9wgde	458	43	models	model	NNS
cord-336510-qzm9wgde	458	44	with	with	IN
cord-336510-qzm9wgde	458	45	several	several	JJ
cord-336510-qzm9wgde	458	46	stages	stage	NNS
cord-336510-qzm9wgde	458	47	of	of	IN
cord-336510-qzm9wgde	458	48	infection	infection	NN
cord-336510-qzm9wgde	458	49	and	and	CC
cord-336510-qzm9wgde	458	50	involvement	involvement	NN
cord-336510-qzm9wgde	458	51	of	of	IN
cord-336510-qzm9wgde	458	52	different	different	JJ
cord-336510-qzm9wgde	458	53	organs	organ	NNS
cord-336510-qzm9wgde	458	54	.	.	.
cord-336510-qzm9wgde	459	1	Such	such	JJ
cord-336510-qzm9wgde	459	2	models	model	NNS
cord-336510-qzm9wgde	459	3	are	be	VBP
cord-336510-qzm9wgde	459	4	,	,	,
cord-336510-qzm9wgde	459	5	however	however	RB
cord-336510-qzm9wgde	459	6	,	,	,
cord-336510-qzm9wgde	459	7	more	more	RBR
cord-336510-qzm9wgde	459	8	close	close	JJ
cord-336510-qzm9wgde	459	9	to	to	IN
cord-336510-qzm9wgde	459	10	the	the	DT
cord-336510-qzm9wgde	459	11	normal	normal	JJ
cord-336510-qzm9wgde	459	12	human	human	JJ
cord-336510-qzm9wgde	459	13	HSV	HSV	NNP
cord-336510-qzm9wgde	459	14	infection	infection	NN
cord-336510-qzm9wgde	459	15	,	,	,
cord-336510-qzm9wgde	459	16	starting	start	VBG
cord-336510-qzm9wgde	459	17	at	at	IN
cord-336510-qzm9wgde	459	18	an	an	DT
cord-336510-qzm9wgde	459	19	epithelial	epithelial	JJ
cord-336510-qzm9wgde	459	20	surface	surface	NN
cord-336510-qzm9wgde	459	21	,	,	,
cord-336510-qzm9wgde	459	22	but	but	CC
cord-336510-qzm9wgde	459	23	to	to	TO
cord-336510-qzm9wgde	459	24	expect	expect	VB
cord-336510-qzm9wgde	459	25	that	that	IN
cord-336510-qzm9wgde	459	26	one	one	CD
cord-336510-qzm9wgde	459	27	resistance	resistance	NN
cord-336510-qzm9wgde	459	28	factor	factor	NN
cord-336510-qzm9wgde	459	29	in	in	IN
cord-336510-qzm9wgde	459	30	such	such	PDT
cord-336510-qzm9wgde	459	31	a	a	DT
cord-336510-qzm9wgde	459	32	complicated	complicated	JJ
cord-336510-qzm9wgde	459	33	system	system	NN
cord-336510-qzm9wgde	459	34	will	will	MD
cord-336510-qzm9wgde	459	35	come	come	VB
cord-336510-qzm9wgde	459	36	out	out	RP
cord-336510-qzm9wgde	459	37	clear	clear	JJ
cord-336510-qzm9wgde	459	38	as	as	IN
cord-336510-qzm9wgde	459	39	the	the	DT
cord-336510-qzm9wgde	459	40	responsible	responsible	JJ
cord-336510-qzm9wgde	459	41	factor	factor	NN
cord-336510-qzm9wgde	459	42	for	for	IN
cord-336510-qzm9wgde	459	43	the	the	DT
cord-336510-qzm9wgde	459	44	outcome	outcome	NN
cord-336510-qzm9wgde	459	45	downstream	downstream	IN
cord-336510-qzm9wgde	459	46	the	the	DT
cord-336510-qzm9wgde	459	47	sequence	sequence	NN
cord-336510-qzm9wgde	459	48	of	of	IN
cord-336510-qzm9wgde	459	49	events	event	NNS
cord-336510-qzm9wgde	459	50	,	,	,
cord-336510-qzm9wgde	459	51	is	be	VBZ
cord-336510-qzm9wgde	459	52	too	too	RB
cord-336510-qzm9wgde	459	53	simplistic	simplistic	JJ
cord-336510-qzm9wgde	459	54	.	.	.
cord-336510-qzm9wgde	460	1	Nevertheless	nevertheless	RB
cord-336510-qzm9wgde	460	2	,	,	,
cord-336510-qzm9wgde	460	3	induced	induce	VBN
cord-336510-qzm9wgde	460	4	expression	expression	NN
cord-336510-qzm9wgde	460	5	of	of	IN
cord-336510-qzm9wgde	460	6	IFN	IFN	NNP
cord-336510-qzm9wgde	460	7	-	-	HYPH
cord-336510-qzm9wgde	460	8	α	α	NNP
cord-336510-qzm9wgde	460	9	/	/	SYM
cord-336510-qzm9wgde	460	10	β	β	NN
cord-336510-qzm9wgde	460	11	in	in	IN
cord-336510-qzm9wgde	460	12	the	the	DT
cord-336510-qzm9wgde	460	13	eye	eye	NN
cord-336510-qzm9wgde	460	14	by	by	IN
cord-336510-qzm9wgde	460	15	plasmid	plasmid	NN
cord-336510-qzm9wgde	460	16	DNA	dna	NN
cord-336510-qzm9wgde	460	17	or	or	CC
cord-336510-qzm9wgde	460	18	an	an	DT
cord-336510-qzm9wgde	460	19	adenovirus	adenovirus	NN
cord-336510-qzm9wgde	460	20	vector	vector	NN
cord-336510-qzm9wgde	460	21	was	be	VBD
cord-336510-qzm9wgde	460	22	shown	show	VBN
cord-336510-qzm9wgde	460	23	to	to	TO
cord-336510-qzm9wgde	460	24	inhibit	inhibit	VB
cord-336510-qzm9wgde	460	25	early	early	JJ
cord-336510-qzm9wgde	460	26	local	local	JJ
cord-336510-qzm9wgde	460	27	replication	replication	NN
cord-336510-qzm9wgde	460	28	of	of	IN
cord-336510-qzm9wgde	460	29	HSV	HSV	NNP
cord-336510-qzm9wgde	460	30	and	and	CC
cord-336510-qzm9wgde	460	31	the	the	DT
cord-336510-qzm9wgde	460	32	concomitant	concomitant	JJ
cord-336510-qzm9wgde	460	33	spread	spread	NN
cord-336510-qzm9wgde	460	34	of	of	IN
cord-336510-qzm9wgde	460	35	virus	virus	NN
cord-336510-qzm9wgde	460	36	to	to	IN
cord-336510-qzm9wgde	460	37	the	the	DT
cord-336510-qzm9wgde	460	38	brain	brain	NN
cord-336510-qzm9wgde	460	39	and	and	CC
cord-336510-qzm9wgde	460	40	death	death	NN
cord-336510-qzm9wgde	460	41	from	from	IN
cord-336510-qzm9wgde	460	42	encephalitis	encephalitis	NN
cord-336510-qzm9wgde	460	43	[	[	-LRB-
cord-336510-qzm9wgde	460	44	333	333	CD
cord-336510-qzm9wgde	460	45	,	,	,
cord-336510-qzm9wgde	460	46	364	364	CD
cord-336510-qzm9wgde	460	47	]	]	-RRB-
cord-336510-qzm9wgde	460	48	,	,	,
cord-336510-qzm9wgde	460	49	and	and	CC
cord-336510-qzm9wgde	460	50	in	in	IN
cord-336510-qzm9wgde	460	51	IFN	IFN	NNP
cord-336510-qzm9wgde	460	52	-	-	HYPH
cord-336510-qzm9wgde	460	53	α	α	NNP
cord-336510-qzm9wgde	460	54	/	/	SYM
cord-336510-qzm9wgde	460	55	βR	βR	NNP
cord-336510-qzm9wgde	460	56	KO	ko	NN
cord-336510-qzm9wgde	460	57	-	-	HYPH
cord-336510-qzm9wgde	460	58	mice	mice	NN
cord-336510-qzm9wgde	460	59	HSV	HSV	NNP
cord-336510-qzm9wgde	460	60	replicated	replicate	VBD
cord-336510-qzm9wgde	460	61	to	to	IN
cord-336510-qzm9wgde	460	62	much	much	RB
cord-336510-qzm9wgde	460	63	higher	high	JJR
cord-336510-qzm9wgde	460	64	titres	titre	NNS
cord-336510-qzm9wgde	460	65	than	than	IN
cord-336510-qzm9wgde	460	66	in	in	IN
cord-336510-qzm9wgde	460	67	normal	normal	JJ
cord-336510-qzm9wgde	460	68	mice	mouse	NNS
cord-336510-qzm9wgde	460	69	[	[	-LRB-
cord-336510-qzm9wgde	460	70	297	297	CD
cord-336510-qzm9wgde	460	71	]	]	-RRB-
cord-336510-qzm9wgde	460	72	.	.	.
cord-336510-qzm9wgde	461	1	This	this	DT
cord-336510-qzm9wgde	461	2	tells	tell	VBZ
cord-336510-qzm9wgde	461	3	us	-PRON-	PRP
cord-336510-qzm9wgde	461	4	that	that	IN
cord-336510-qzm9wgde	461	5	the	the	DT
cord-336510-qzm9wgde	461	6	innate	innate	JJ
cord-336510-qzm9wgde	461	7	and	and	CC
cord-336510-qzm9wgde	461	8	adaptive	adaptive	JJ
cord-336510-qzm9wgde	461	9	immune	immune	JJ
cord-336510-qzm9wgde	461	10	systems	system	NNS
cord-336510-qzm9wgde	461	11	exhibit	exhibit	VBP
cord-336510-qzm9wgde	461	12	much	much	JJ
cord-336510-qzm9wgde	461	13	redundancy	redundancy	NN
cord-336510-qzm9wgde	461	14	,	,	,
cord-336510-qzm9wgde	461	15	and	and	CC
cord-336510-qzm9wgde	461	16	that	that	IN
cord-336510-qzm9wgde	461	17	IFN	IFN	NNP
cord-336510-qzm9wgde	461	18	-	-	HYPH
cord-336510-qzm9wgde	461	19	α	α	NNP
cord-336510-qzm9wgde	461	20	/	/	SYM
cord-336510-qzm9wgde	461	21	β	β	NN
cord-336510-qzm9wgde	461	22	is	be	VBZ
cord-336510-qzm9wgde	461	23	of	of	IN
cord-336510-qzm9wgde	461	24	vital	vital	JJ
cord-336510-qzm9wgde	461	25	importance	importance	NN
cord-336510-qzm9wgde	461	26	in	in	IN
cord-336510-qzm9wgde	461	27	local	local	JJ
cord-336510-qzm9wgde	461	28	inhibition	inhibition	NN
cord-336510-qzm9wgde	461	29	of	of	IN
cord-336510-qzm9wgde	461	30	HSV	HSV	NNP
cord-336510-qzm9wgde	461	31	replication	replication	NN
cord-336510-qzm9wgde	461	32	.	.	.
cord-336510-qzm9wgde	462	1	The	the	DT
cord-336510-qzm9wgde	462	2	multitude	multitude	NN
cord-336510-qzm9wgde	462	3	of	of	IN
cord-336510-qzm9wgde	462	4	antiviral	antiviral	JJ
cord-336510-qzm9wgde	462	5	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	462	6	,	,	,
cord-336510-qzm9wgde	462	7	be	be	VB
cord-336510-qzm9wgde	462	8	it	-PRON-	PRP
cord-336510-qzm9wgde	462	9	innate	innate	JJ
cord-336510-qzm9wgde	462	10	or	or	CC
cord-336510-qzm9wgde	462	11	adaptive	adaptive	JJ
cord-336510-qzm9wgde	462	12	,	,	,
cord-336510-qzm9wgde	462	13	have	have	VBP
cord-336510-qzm9wgde	462	14	varying	vary	VBG
cord-336510-qzm9wgde	462	15	effects	effect	NNS
cord-336510-qzm9wgde	462	16	and	and	CC
cord-336510-qzm9wgde	462	17	importance	importance	NN
cord-336510-qzm9wgde	462	18	in	in	IN
cord-336510-qzm9wgde	462	19	the	the	DT
cord-336510-qzm9wgde	462	20	different	different	JJ
cord-336510-qzm9wgde	462	21	phases	phase	NNS
cord-336510-qzm9wgde	462	22	of	of	IN
cord-336510-qzm9wgde	462	23	infection	infection	NN
cord-336510-qzm9wgde	462	24	,	,	,
cord-336510-qzm9wgde	462	25	such	such	JJ
cord-336510-qzm9wgde	462	26	as	as	IN
cord-336510-qzm9wgde	462	27	initial	initial	JJ
cord-336510-qzm9wgde	462	28	local	local	JJ
cord-336510-qzm9wgde	462	29	infection	infection	NN
cord-336510-qzm9wgde	462	30	,	,	,
cord-336510-qzm9wgde	462	31	dissemination	dissemination	NN
cord-336510-qzm9wgde	462	32	to	to	IN
cord-336510-qzm9wgde	462	33	other	other	JJ
cord-336510-qzm9wgde	462	34	organs	organ	NNS
cord-336510-qzm9wgde	462	35	,	,	,
cord-336510-qzm9wgde	462	36	establishment	establishment	NN
cord-336510-qzm9wgde	462	37	of	of	IN
cord-336510-qzm9wgde	462	38	latency	latency	NN
cord-336510-qzm9wgde	462	39	and	and	CC
cord-336510-qzm9wgde	462	40	reactivation	reactivation	NN
cord-336510-qzm9wgde	462	41	,	,	,
cord-336510-qzm9wgde	462	42	and	and	CC
cord-336510-qzm9wgde	462	43	conclusions	conclusion	NNS
cord-336510-qzm9wgde	462	44	can	can	MD
cord-336510-qzm9wgde	462	45	not	not	RB
cord-336510-qzm9wgde	462	46	be	be	VB
cord-336510-qzm9wgde	462	47	drawn	draw	VBN
cord-336510-qzm9wgde	462	48	from	from	IN
cord-336510-qzm9wgde	462	49	one	one	CD
cord-336510-qzm9wgde	462	50	situation	situation	NN
cord-336510-qzm9wgde	462	51	to	to	IN
cord-336510-qzm9wgde	462	52	another	another	DT
cord-336510-qzm9wgde	462	53	.	.	.
cord-336510-qzm9wgde	463	1	The	the	DT
cord-336510-qzm9wgde	463	2	reactions	reaction	NNS
cord-336510-qzm9wgde	463	3	discussed	discuss	VBN
cord-336510-qzm9wgde	463	4	above	above	RB
cord-336510-qzm9wgde	463	5	,	,	,
cord-336510-qzm9wgde	463	6	involving	involve	VBG
cord-336510-qzm9wgde	463	7	production	production	NN
cord-336510-qzm9wgde	463	8	of	of	IN
cord-336510-qzm9wgde	463	9	IFN	IFN	NNP
cord-336510-qzm9wgde	463	10	-	-	HYPH
cord-336510-qzm9wgde	463	11	α	α	NNP
cord-336510-qzm9wgde	463	12	/	/	SYM
cord-336510-qzm9wgde	463	13	β	β	NN
cord-336510-qzm9wgde	463	14	and	and	CC
cord-336510-qzm9wgde	463	15	TNF	TNF	NNP
cord-336510-qzm9wgde	463	16	,	,	,
cord-336510-qzm9wgde	463	17	take	take	VB
cord-336510-qzm9wgde	463	18	place	place	NN
cord-336510-qzm9wgde	463	19	within	within	IN
cord-336510-qzm9wgde	463	20	the	the	DT
cord-336510-qzm9wgde	463	21	first	first	JJ
cord-336510-qzm9wgde	463	22	6	6	CD
cord-336510-qzm9wgde	463	23	to	to	TO
cord-336510-qzm9wgde	463	24	12	12	CD
cord-336510-qzm9wgde	463	25	hours	hour	NNS
cord-336510-qzm9wgde	463	26	of	of	IN
cord-336510-qzm9wgde	463	27	a	a	DT
cord-336510-qzm9wgde	463	28	HSV	HSV	NNP
cord-336510-qzm9wgde	463	29	infection	infection	NN
cord-336510-qzm9wgde	463	30	,	,	,
cord-336510-qzm9wgde	463	31	and	and	CC
cord-336510-qzm9wgde	463	32	thus	thus	RB
cord-336510-qzm9wgde	463	33	are	be	VBP
cord-336510-qzm9wgde	463	34	reactions	reaction	NNS
cord-336510-qzm9wgde	463	35	,	,	,
cord-336510-qzm9wgde	463	36	which	which	WDT
cord-336510-qzm9wgde	463	37	can	can	MD
cord-336510-qzm9wgde	463	38	execute	execute	VB
cord-336510-qzm9wgde	463	39	an	an	DT
cord-336510-qzm9wgde	463	40	effect	effect	NN
cord-336510-qzm9wgde	463	41	within	within	IN
cord-336510-qzm9wgde	463	42	the	the	DT
cord-336510-qzm9wgde	463	43	first	first	JJ
cord-336510-qzm9wgde	463	44	replication	replication	NN
cord-336510-qzm9wgde	463	45	cycle	cycle	NN
cord-336510-qzm9wgde	463	46	of	of	IN
cord-336510-qzm9wgde	463	47	the	the	DT
cord-336510-qzm9wgde	463	48	virus	virus	NN
cord-336510-qzm9wgde	463	49	.	.	.
cord-336510-qzm9wgde	464	1	A	a	DT
cord-336510-qzm9wgde	464	2	little	little	JJ
cord-336510-qzm9wgde	464	3	later	later	RB
cord-336510-qzm9wgde	464	4	,	,	,
cord-336510-qzm9wgde	464	5	other	other	JJ
cord-336510-qzm9wgde	464	6	cytokines	cytokine	NNS
cord-336510-qzm9wgde	464	7	such	such	JJ
cord-336510-qzm9wgde	464	8	as	as	IN
cord-336510-qzm9wgde	464	9	IL-12	IL-12	NNP
cord-336510-qzm9wgde	464	10	,	,	,
cord-336510-qzm9wgde	464	11	IL-18	IL-18	NNP
cord-336510-qzm9wgde	464	12	and	and	CC
cord-336510-qzm9wgde	464	13	IFN	IFN	NNP
cord-336510-qzm9wgde	464	14	-	-	HYPH
cord-336510-qzm9wgde	464	15	γ	γ	NNP
cord-336510-qzm9wgde	464	16	are	be	VBP
cord-336510-qzm9wgde	464	17	produced	produce	VBN
cord-336510-qzm9wgde	464	18	and	and	CC
cord-336510-qzm9wgde	464	19	give	give	VB
cord-336510-qzm9wgde	464	20	rise	rise	NN
cord-336510-qzm9wgde	464	21	to	to	IN
cord-336510-qzm9wgde	464	22	other	other	JJ
cord-336510-qzm9wgde	464	23	weapons	weapon	NNS
cord-336510-qzm9wgde	464	24	in	in	IN
cord-336510-qzm9wgde	464	25	the	the	DT
cord-336510-qzm9wgde	464	26	battle	battle	NN
cord-336510-qzm9wgde	464	27	against	against	IN
cord-336510-qzm9wgde	464	28	the	the	DT
cord-336510-qzm9wgde	464	29	virus	virus	NN
cord-336510-qzm9wgde	464	30	.	.	.
cord-336510-qzm9wgde	465	1	They	-PRON-	PRP
cord-336510-qzm9wgde	465	2	will	will	MD
cord-336510-qzm9wgde	465	3	,	,	,
cord-336510-qzm9wgde	465	4	in	in	IN
cord-336510-qzm9wgde	465	5	turn	turn	NN
cord-336510-qzm9wgde	465	6	,	,	,
cord-336510-qzm9wgde	465	7	within	within	IN
cord-336510-qzm9wgde	465	8	the	the	DT
cord-336510-qzm9wgde	465	9	next	next	JJ
cord-336510-qzm9wgde	465	10	replication	replication	NN
cord-336510-qzm9wgde	465	11	cycle	cycle	NN
cord-336510-qzm9wgde	465	12	execute	execute	VBP
cord-336510-qzm9wgde	465	13	their	-PRON-	PRP$
cord-336510-qzm9wgde	465	14	actions	action	NNS
cord-336510-qzm9wgde	465	15	,	,	,
cord-336510-qzm9wgde	465	16	with	with	IN
cord-336510-qzm9wgde	465	17	potential	potential	JJ
cord-336510-qzm9wgde	465	18	harmful	harmful	JJ
cord-336510-qzm9wgde	465	19	consequences	consequence	NNS
cord-336510-qzm9wgde	465	20	for	for	IN
cord-336510-qzm9wgde	465	21	either	either	DT
cord-336510-qzm9wgde	465	22	parts	part	NNS
cord-336510-qzm9wgde	465	23	of	of	IN
cord-336510-qzm9wgde	465	24	the	the	DT
cord-336510-qzm9wgde	465	25	conflict	conflict	NN
cord-336510-qzm9wgde	465	26	.	.	.
cord-336510-qzm9wgde	466	1	A	a	DT
cord-336510-qzm9wgde	466	2	few	few	JJ
cord-336510-qzm9wgde	466	3	hours	hour	NNS
cord-336510-qzm9wgde	466	4	after	after	IN
cord-336510-qzm9wgde	466	5	the	the	DT
cord-336510-qzm9wgde	466	6	type	type	NN
cord-336510-qzm9wgde	466	7	I	-PRON-	PRP
cord-336510-qzm9wgde	466	8	IFN	IFN	NNP
cord-336510-qzm9wgde	466	9	and	and	CC
cord-336510-qzm9wgde	466	10	TNF	TNF	NNP
cord-336510-qzm9wgde	466	11	response	response	NN
cord-336510-qzm9wgde	466	12	,	,	,
cord-336510-qzm9wgde	466	13	macrophages	macrophage	NNS
cord-336510-qzm9wgde	466	14	react	react	VBP
cord-336510-qzm9wgde	466	15	upon	upon	IN
cord-336510-qzm9wgde	466	16	HSV	HSV	NNP
cord-336510-qzm9wgde	466	17	infection	infection	NN
cord-336510-qzm9wgde	466	18	with	with	IN
cord-336510-qzm9wgde	466	19	production	production	NN
cord-336510-qzm9wgde	466	20	of	of	IN
cord-336510-qzm9wgde	466	21	IL-12	IL-12	NNP
cord-336510-qzm9wgde	466	22	,	,	,
cord-336510-qzm9wgde	466	23	which	which	WDT
cord-336510-qzm9wgde	466	24	is	be	VBZ
cord-336510-qzm9wgde	466	25	seen	see	VBN
cord-336510-qzm9wgde	466	26	from	from	IN
cord-336510-qzm9wgde	466	27	8	8	CD
cord-336510-qzm9wgde	466	28	to	to	TO
cord-336510-qzm9wgde	466	29	12	12	CD
cord-336510-qzm9wgde	466	30	hours	hour	NNS
cord-336510-qzm9wgde	466	31	after	after	IN
cord-336510-qzm9wgde	466	32	infection	infection	NN
cord-336510-qzm9wgde	466	33	and	and	CC
cord-336510-qzm9wgde	466	34	on	on	IN
cord-336510-qzm9wgde	466	35	[	[	-LRB-
cord-336510-qzm9wgde	466	36	238	238	CD
cord-336510-qzm9wgde	466	37	,	,	,
cord-336510-qzm9wgde	466	38	365	365	CD
cord-336510-qzm9wgde	466	39	]	]	-RRB-
cord-336510-qzm9wgde	466	40	.	.	.
cord-336510-qzm9wgde	467	1	The	the	DT
cord-336510-qzm9wgde	467	2	same	same	JJ
cord-336510-qzm9wgde	467	3	was	be	VBD
cord-336510-qzm9wgde	467	4	found	find	VBN
cord-336510-qzm9wgde	467	5	with	with	IN
cord-336510-qzm9wgde	467	6	other	other	JJ
cord-336510-qzm9wgde	467	7	viruses	virus	NNS
cord-336510-qzm9wgde	467	8	12	12	CD
cord-336510-qzm9wgde	467	9	to	to	TO
cord-336510-qzm9wgde	467	10	24	24	CD
cord-336510-qzm9wgde	467	11	hours	hour	NNS
cord-336510-qzm9wgde	467	12	after	after	IN
cord-336510-qzm9wgde	467	13	infection	infection	NN
cord-336510-qzm9wgde	467	14	[	[	-LRB-
cord-336510-qzm9wgde	467	15	366	366	CD
cord-336510-qzm9wgde	467	16	]	]	-RRB-
cord-336510-qzm9wgde	467	17	.	.	.
cord-336510-qzm9wgde	468	1	In	in	IN
cord-336510-qzm9wgde	468	2	these	these	DT
cord-336510-qzm9wgde	468	3	and	and	CC
cord-336510-qzm9wgde	468	4	other	other	JJ
cord-336510-qzm9wgde	468	5	studies	study	NNS
cord-336510-qzm9wgde	468	6	,	,	,
cord-336510-qzm9wgde	468	7	the	the	DT
cord-336510-qzm9wgde	468	8	producers	producer	NNS
cord-336510-qzm9wgde	468	9	of	of	IN
cord-336510-qzm9wgde	468	10	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	468	11	during	during	IN
cord-336510-qzm9wgde	468	12	viral	viral	JJ
cord-336510-qzm9wgde	468	13	infection	infection	NN
cord-336510-qzm9wgde	468	14	seem	seem	VBP
cord-336510-qzm9wgde	468	15	to	to	TO
cord-336510-qzm9wgde	468	16	be	be	VB
cord-336510-qzm9wgde	468	17	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	468	18	cells	cell	NNS
cord-336510-qzm9wgde	468	19	,	,	,
cord-336510-qzm9wgde	468	20	including	include	VBG
cord-336510-qzm9wgde	468	21	macrophages	macrophage	NNS
cord-336510-qzm9wgde	468	22	,	,	,
cord-336510-qzm9wgde	468	23	and	and	CC
cord-336510-qzm9wgde	468	24	not	not	RB
cord-336510-qzm9wgde	468	25	the	the	DT
cord-336510-qzm9wgde	468	26	infected	infected	JJ
cord-336510-qzm9wgde	468	27	stromal	stromal	NN
cord-336510-qzm9wgde	468	28	cells	cell	NNS
cord-336510-qzm9wgde	468	29	[	[	-LRB-
cord-336510-qzm9wgde	468	30	365	365	CD
cord-336510-qzm9wgde	468	31	,	,	,
cord-336510-qzm9wgde	468	32	367	367	CD
cord-336510-qzm9wgde	468	33	]	]	-RRB-
cord-336510-qzm9wgde	468	34	.	.	.
cord-336510-qzm9wgde	469	1	The	the	DT
cord-336510-qzm9wgde	469	2	IL-12	IL-12	NNP
cord-336510-qzm9wgde	469	3	induction	induction	NN
cord-336510-qzm9wgde	469	4	during	during	IN
cord-336510-qzm9wgde	469	5	HSV	HSV	NNP
cord-336510-qzm9wgde	469	6	infection	infection	NN
cord-336510-qzm9wgde	469	7	requires	require	VBZ
cord-336510-qzm9wgde	469	8	infectious	infectious	JJ
cord-336510-qzm9wgde	469	9	virus	virus	NN
cord-336510-qzm9wgde	469	10	,	,	,
cord-336510-qzm9wgde	469	11	and	and	CC
cord-336510-qzm9wgde	469	12	it	-PRON-	PRP
cord-336510-qzm9wgde	469	13	was	be	VBD
cord-336510-qzm9wgde	469	14	shown	show	VBN
cord-336510-qzm9wgde	469	15	to	to	TO
cord-336510-qzm9wgde	469	16	be	be	VB
cord-336510-qzm9wgde	469	17	regulated	regulate	VBN
cord-336510-qzm9wgde	469	18	at	at	IN
cord-336510-qzm9wgde	469	19	the	the	DT
cord-336510-qzm9wgde	469	20	transcriptional	transcriptional	JJ
cord-336510-qzm9wgde	469	21	level	level	NN
cord-336510-qzm9wgde	469	22	[	[	-LRB-
cord-336510-qzm9wgde	469	23	238	238	CD
cord-336510-qzm9wgde	469	24	]	]	-RRB-
cord-336510-qzm9wgde	469	25	,	,	,
cord-336510-qzm9wgde	469	26	as	as	IN
cord-336510-qzm9wgde	469	27	it	-PRON-	PRP
cord-336510-qzm9wgde	469	28	is	be	VBZ
cord-336510-qzm9wgde	469	29	also	also	RB
cord-336510-qzm9wgde	469	30	the	the	DT
cord-336510-qzm9wgde	469	31	case	case	NN
cord-336510-qzm9wgde	469	32	when	when	WRB
cord-336510-qzm9wgde	469	33	it	-PRON-	PRP
cord-336510-qzm9wgde	469	34	is	be	VBZ
cord-336510-qzm9wgde	469	35	induced	induce	VBN
cord-336510-qzm9wgde	469	36	by	by	IN
cord-336510-qzm9wgde	469	37	LPS	LPS	NNP
cord-336510-qzm9wgde	469	38	[	[	-LRB-
cord-336510-qzm9wgde	469	39	247	247	CD
cord-336510-qzm9wgde	469	40	,	,	,
cord-336510-qzm9wgde	469	41	367	367	CD
cord-336510-qzm9wgde	469	42	]	]	-RRB-
cord-336510-qzm9wgde	469	43	.	.	.
cord-336510-qzm9wgde	470	1	The	the	DT
cord-336510-qzm9wgde	470	2	dependence	dependence	NN
cord-336510-qzm9wgde	470	3	on	on	IN
cord-336510-qzm9wgde	470	4	infectivity	infectivity	NN
cord-336510-qzm9wgde	470	5	is	be	VBZ
cord-336510-qzm9wgde	470	6	,	,	,
cord-336510-qzm9wgde	470	7	however	however	RB
cord-336510-qzm9wgde	470	8	,	,	,
cord-336510-qzm9wgde	470	9	in	in	IN
cord-336510-qzm9wgde	470	10	conflict	conflict	NN
cord-336510-qzm9wgde	470	11	with	with	IN
cord-336510-qzm9wgde	470	12	results	result	NNS
cord-336510-qzm9wgde	470	13	from	from	IN
cord-336510-qzm9wgde	470	14	in	in	IN
cord-336510-qzm9wgde	470	15	vivo	vivo	NN
cord-336510-qzm9wgde	470	16	production	production	NN
cord-336510-qzm9wgde	470	17	of	of	IN
cord-336510-qzm9wgde	470	18	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	470	19	and	and	CC
cord-336510-qzm9wgde	470	20	IFN	IFN	NNP
cord-336510-qzm9wgde	470	21	-	-	HYPH
cord-336510-qzm9wgde	470	22	γ	γ	NNP
cord-336510-qzm9wgde	470	23	in	in	IN
cord-336510-qzm9wgde	470	24	draining	drain	VBG
cord-336510-qzm9wgde	470	25	lymph	lymph	NN
cord-336510-qzm9wgde	470	26	nodes	node	NNS
cord-336510-qzm9wgde	470	27	from	from	IN
cord-336510-qzm9wgde	470	28	sites	site	NNS
cord-336510-qzm9wgde	470	29	injected	inject	VBN
cord-336510-qzm9wgde	470	30	with	with	IN
cord-336510-qzm9wgde	470	31	UV	uv	NN
cord-336510-qzm9wgde	470	32	-	-	HYPH
cord-336510-qzm9wgde	470	33	inactivated	inactivate	VBN
cord-336510-qzm9wgde	470	34	HSV	HSV	NNP
cord-336510-qzm9wgde	470	35	[	[	-LRB-
cord-336510-qzm9wgde	470	36	302	302	CD
cord-336510-qzm9wgde	470	37	]	]	-RRB-
cord-336510-qzm9wgde	470	38	.	.	.
cord-336510-qzm9wgde	471	1	High	high	JJ
cord-336510-qzm9wgde	471	2	doses	dose	NNS
cord-336510-qzm9wgde	471	3	of	of	IN
cord-336510-qzm9wgde	471	4	UV	uv	NN
cord-336510-qzm9wgde	471	5	-	-	HYPH
cord-336510-qzm9wgde	471	6	inactivated	inactivate	VBN
cord-336510-qzm9wgde	471	7	virus	virus	NN
cord-336510-qzm9wgde	471	8	were	be	VBD
cord-336510-qzm9wgde	471	9	used	use	VBN
cord-336510-qzm9wgde	471	10	,	,	,
cord-336510-qzm9wgde	471	11	and	and	CC
cord-336510-qzm9wgde	471	12	some	some	DT
cord-336510-qzm9wgde	471	13	minimal	minimal	JJ
cord-336510-qzm9wgde	471	14	transcription	transcription	NN
cord-336510-qzm9wgde	471	15	of	of	IN
cord-336510-qzm9wgde	471	16	viral	viral	JJ
cord-336510-qzm9wgde	471	17	genes	gene	NNS
cord-336510-qzm9wgde	471	18	could	could	MD
cord-336510-qzm9wgde	471	19	have	have	VB
cord-336510-qzm9wgde	471	20	taken	take	VBN
cord-336510-qzm9wgde	471	21	place	place	NN
cord-336510-qzm9wgde	471	22	,	,	,
cord-336510-qzm9wgde	471	23	although	although	IN
cord-336510-qzm9wgde	471	24	the	the	DT
cord-336510-qzm9wgde	471	25	virus	virus	NN
cord-336510-qzm9wgde	471	26	was	be	VBD
cord-336510-qzm9wgde	471	27	not	not	RB
cord-336510-qzm9wgde	471	28	replication	replication	NN
cord-336510-qzm9wgde	471	29	competent	competent	JJ
cord-336510-qzm9wgde	471	30	.	.	.
cord-336510-qzm9wgde	472	1	Transcription	transcription	NN
cord-336510-qzm9wgde	472	2	of	of	IN
cord-336510-qzm9wgde	472	3	the	the	DT
cord-336510-qzm9wgde	472	4	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	472	5	gene	gene	NN
cord-336510-qzm9wgde	472	6	in	in	IN
cord-336510-qzm9wgde	472	7	macrophages	macrophage	NNS
cord-336510-qzm9wgde	472	8	requires	require	VBZ
cord-336510-qzm9wgde	472	9	de	de	NNP
cord-336510-qzm9wgde	472	10	novo	novo	NNP
cord-336510-qzm9wgde	472	11	protein	protein	NN
cord-336510-qzm9wgde	472	12	synthesis	synthesis	NN
cord-336510-qzm9wgde	472	13	during	during	IN
cord-336510-qzm9wgde	472	14	the	the	DT
cord-336510-qzm9wgde	472	15	inducing	induce	VBG
cord-336510-qzm9wgde	472	16	HSV	HSV	NNP
cord-336510-qzm9wgde	472	17	infection	infection	NN
cord-336510-qzm9wgde	472	18	,	,	,
cord-336510-qzm9wgde	472	19	which	which	WDT
cord-336510-qzm9wgde	472	20	could	could	MD
cord-336510-qzm9wgde	472	21	explain	explain	VB
cord-336510-qzm9wgde	472	22	the	the	DT
cord-336510-qzm9wgde	472	23	relatively	relatively	RB
cord-336510-qzm9wgde	472	24	late	late	JJ
cord-336510-qzm9wgde	472	25	appearance	appearance	NN
cord-336510-qzm9wgde	472	26	of	of	IN
cord-336510-qzm9wgde	472	27	IL-12	IL-12	NNP
cord-336510-qzm9wgde	472	28	production	production	NN
cord-336510-qzm9wgde	472	29	[	[	-LRB-
cord-336510-qzm9wgde	472	30	238	238	CD
cord-336510-qzm9wgde	472	31	,	,	,
cord-336510-qzm9wgde	472	32	367	367	CD
cord-336510-qzm9wgde	472	33	]	]	-RRB-
cord-336510-qzm9wgde	472	34	.	.	.
cord-336510-qzm9wgde	473	1	The	the	DT
cord-336510-qzm9wgde	473	2	κB	κb	CD
cord-336510-qzm9wgde	473	3	-	-	HYPH
cord-336510-qzm9wgde	473	4	sequence	sequence	NN
cord-336510-qzm9wgde	473	5	of	of	IN
cord-336510-qzm9wgde	473	6	the	the	DT
cord-336510-qzm9wgde	473	7	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	473	8	promoter	promoter	NN
cord-336510-qzm9wgde	473	9	binds	bind	VBZ
cord-336510-qzm9wgde	473	10	NF	nf	NN
cord-336510-qzm9wgde	473	11	-	-	HYPH
cord-336510-qzm9wgde	473	12	κB	κB	NNP
cord-336510-qzm9wgde	473	13	in	in	IN
cord-336510-qzm9wgde	473	14	HSV	HSV	NNP
cord-336510-qzm9wgde	473	15	-	-	HYPH
cord-336510-qzm9wgde	473	16	infected	infect	VBN
cord-336510-qzm9wgde	473	17	cells	cell	NNS
cord-336510-qzm9wgde	473	18	,	,	,
cord-336510-qzm9wgde	473	19	and	and	CC
cord-336510-qzm9wgde	473	20	the	the	DT
cord-336510-qzm9wgde	473	21	production	production	NN
cord-336510-qzm9wgde	473	22	of	of	IN
cord-336510-qzm9wgde	473	23	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	473	24	was	be	VBD
cord-336510-qzm9wgde	473	25	found	find	VBN
cord-336510-qzm9wgde	473	26	to	to	TO
cord-336510-qzm9wgde	473	27	be	be	VB
cord-336510-qzm9wgde	473	28	repressed	repress	VBN
cord-336510-qzm9wgde	473	29	by	by	IN
cord-336510-qzm9wgde	473	30	an	an	DT
cord-336510-qzm9wgde	473	31	inhibitor	inhibitor	NN
cord-336510-qzm9wgde	473	32	of	of	IN
cord-336510-qzm9wgde	473	33	NF	nf	NN
cord-336510-qzm9wgde	473	34	-	-	HYPH
cord-336510-qzm9wgde	473	35	κB	κb	CD
cord-336510-qzm9wgde	473	36	activation	activation	NN
cord-336510-qzm9wgde	473	37	[	[	-LRB-
cord-336510-qzm9wgde	473	38	238	238	CD
cord-336510-qzm9wgde	473	39	]	]	-RRB-
cord-336510-qzm9wgde	473	40	.	.	.
cord-336510-qzm9wgde	474	1	Both	both	CC
cord-336510-qzm9wgde	474	2	these	these	DT
cord-336510-qzm9wgde	474	3	observations	observation	NNS
cord-336510-qzm9wgde	474	4	indicate	indicate	VBP
cord-336510-qzm9wgde	474	5	that	that	IN
cord-336510-qzm9wgde	474	6	signalling	signal	VBG
cord-336510-qzm9wgde	474	7	through	through	IN
cord-336510-qzm9wgde	474	8	NF	nf	NN
cord-336510-qzm9wgde	474	9	-	-	HYPH
cord-336510-qzm9wgde	474	10	κB	κB	NNP
cord-336510-qzm9wgde	474	11	is	be	VBZ
cord-336510-qzm9wgde	474	12	of	of	IN
cord-336510-qzm9wgde	474	13	significance	significance	NN
cord-336510-qzm9wgde	474	14	in	in	IN
cord-336510-qzm9wgde	474	15	HSV	HSV	NNP
cord-336510-qzm9wgde	474	16	-	-	HYPH
cord-336510-qzm9wgde	474	17	induced	induce	VBN
cord-336510-qzm9wgde	474	18	IL-12	IL-12	NNP
cord-336510-qzm9wgde	474	19	production	production	NN
cord-336510-qzm9wgde	474	20	.	.	.
cord-336510-qzm9wgde	475	1	In	in	IN
cord-336510-qzm9wgde	475	2	human	human	JJ
cord-336510-qzm9wgde	475	3	macrophages	macrophage	NNS
cord-336510-qzm9wgde	475	4	,	,	,
cord-336510-qzm9wgde	475	5	TNF	TNF	NNP
cord-336510-qzm9wgde	475	6	has	have	VBZ
cord-336510-qzm9wgde	475	7	been	be	VBN
cord-336510-qzm9wgde	475	8	shown	show	VBN
cord-336510-qzm9wgde	475	9	to	to	TO
cord-336510-qzm9wgde	475	10	inhibit	inhibit	VB
cord-336510-qzm9wgde	475	11	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	475	12	production	production	NN
cord-336510-qzm9wgde	475	13	,	,	,
cord-336510-qzm9wgde	475	14	but	but	CC
cord-336510-qzm9wgde	475	15	not	not	RB
cord-336510-qzm9wgde	475	16	p35	p35	CD
cord-336510-qzm9wgde	475	17	production	production	NN
cord-336510-qzm9wgde	475	18	,	,	,
cord-336510-qzm9wgde	475	19	by	by	IN
cord-336510-qzm9wgde	475	20	a	a	DT
cord-336510-qzm9wgde	475	21	mechanism	mechanism	NN
cord-336510-qzm9wgde	475	22	not	not	RB
cord-336510-qzm9wgde	475	23	involving	involve	VBG
cord-336510-qzm9wgde	475	24	NF	nf	NN
cord-336510-qzm9wgde	475	25	-	-	HYPH
cord-336510-qzm9wgde	475	26	κB	κB	NNP
cord-336510-qzm9wgde	475	27	[	[	-LRB-
cord-336510-qzm9wgde	475	28	368	368	CD
cord-336510-qzm9wgde	475	29	]	]	-RRB-
cord-336510-qzm9wgde	475	30	.	.	.
cord-336510-qzm9wgde	476	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	476	2	,	,	,
cord-336510-qzm9wgde	476	3	IL-12	IL-12	NNP
cord-336510-qzm9wgde	476	4	has	have	VBZ
cord-336510-qzm9wgde	476	5	in	in	IN
cord-336510-qzm9wgde	476	6	a	a	DT
cord-336510-qzm9wgde	476	7	mouse	mouse	NN
cord-336510-qzm9wgde	476	8	model	model	NN
cord-336510-qzm9wgde	476	9	been	be	VBN
cord-336510-qzm9wgde	476	10	shown	show	VBN
cord-336510-qzm9wgde	476	11	to	to	TO
cord-336510-qzm9wgde	476	12	stimulate	stimulate	VB
cord-336510-qzm9wgde	476	13	TNF	TNF	NNP
cord-336510-qzm9wgde	476	14	expression	expression	NN
cord-336510-qzm9wgde	476	15	[	[	-LRB-
cord-336510-qzm9wgde	476	16	255	255	CD
cord-336510-qzm9wgde	476	17	]	]	-RRB-
cord-336510-qzm9wgde	476	18	,	,	,
cord-336510-qzm9wgde	476	19	indicating	indicate	VBG
cord-336510-qzm9wgde	476	20	that	that	IN
cord-336510-qzm9wgde	476	21	TNF	TNF	NNP
cord-336510-qzm9wgde	476	22	can	can	MD
cord-336510-qzm9wgde	476	23	participate	participate	VB
cord-336510-qzm9wgde	476	24	in	in	IN
cord-336510-qzm9wgde	476	25	a	a	DT
cord-336510-qzm9wgde	476	26	negative	negative	JJ
cord-336510-qzm9wgde	476	27	feed	feed	NN
cord-336510-qzm9wgde	476	28	-	-	HYPH
cord-336510-qzm9wgde	476	29	back	back	NN
cord-336510-qzm9wgde	476	30	loop	loop	NN
cord-336510-qzm9wgde	476	31	in	in	IN
cord-336510-qzm9wgde	476	32	the	the	DT
cord-336510-qzm9wgde	476	33	regulation	regulation	NN
cord-336510-qzm9wgde	476	34	of	of	IN
cord-336510-qzm9wgde	476	35	the	the	DT
cord-336510-qzm9wgde	476	36	IL-12	IL-12	NNP
cord-336510-qzm9wgde	476	37	system	system	NN
cord-336510-qzm9wgde	476	38	[	[	-LRB-
cord-336510-qzm9wgde	476	39	369	369	CD
cord-336510-qzm9wgde	476	40	]	]	-RRB-
cord-336510-qzm9wgde	476	41	.	.	.
cord-336510-qzm9wgde	477	1	Likewise	likewise	RB
cord-336510-qzm9wgde	477	2	,	,	,
cord-336510-qzm9wgde	477	3	IFN	IFN	NNP
cord-336510-qzm9wgde	477	4	-	-	HYPH
cord-336510-qzm9wgde	477	5	α	α	NNP
cord-336510-qzm9wgde	477	6	/	/	SYM
cord-336510-qzm9wgde	477	7	β	β	NN
cord-336510-qzm9wgde	477	8	has	have	VBZ
cord-336510-qzm9wgde	477	9	been	be	VBN
cord-336510-qzm9wgde	477	10	shown	show	VBN
cord-336510-qzm9wgde	477	11	to	to	TO
cord-336510-qzm9wgde	477	12	inhibit	inhibit	VB
cord-336510-qzm9wgde	477	13	IL-12	IL-12	NNP
cord-336510-qzm9wgde	477	14	production	production	NN
cord-336510-qzm9wgde	477	15	in	in	IN
cord-336510-qzm9wgde	477	16	both	both	DT
cord-336510-qzm9wgde	477	17	humans	human	NNS
cord-336510-qzm9wgde	477	18	and	and	CC
cord-336510-qzm9wgde	477	19	mice	mouse	NNS
cord-336510-qzm9wgde	477	20	[	[	-LRB-
cord-336510-qzm9wgde	477	21	370	370	CD
cord-336510-qzm9wgde	477	22	]	]	-RRB-
cord-336510-qzm9wgde	477	23	[	[	-LRB-
cord-336510-qzm9wgde	477	24	371	371	CD
cord-336510-qzm9wgde	477	25	]	]	-RRB-
cord-336510-qzm9wgde	477	26	[	[	-LRB-
cord-336510-qzm9wgde	477	27	372	372	CD
cord-336510-qzm9wgde	477	28	]	]	-RRB-
cord-336510-qzm9wgde	477	29	.	.	.
cord-336510-qzm9wgde	478	1	The	the	DT
cord-336510-qzm9wgde	478	2	implication	implication	NN
cord-336510-qzm9wgde	478	3	of	of	IN
cord-336510-qzm9wgde	478	4	such	such	JJ
cord-336510-qzm9wgde	478	5	inhibition	inhibition	NN
cord-336510-qzm9wgde	478	6	by	by	IN
cord-336510-qzm9wgde	478	7	IFN	IFN	NNP
cord-336510-qzm9wgde	478	8	-	-	HYPH
cord-336510-qzm9wgde	478	9	α	α	NNP
cord-336510-qzm9wgde	478	10	/	/	SYM
cord-336510-qzm9wgde	478	11	β	β	NN
cord-336510-qzm9wgde	478	12	and	and	CC
cord-336510-qzm9wgde	478	13	TNF	TNF	NNP
cord-336510-qzm9wgde	478	14	,	,	,
cord-336510-qzm9wgde	478	15	which	which	WDT
cord-336510-qzm9wgde	478	16	are	be	VBP
cord-336510-qzm9wgde	478	17	secreted	secrete	VBN
cord-336510-qzm9wgde	478	18	very	very	RB
cord-336510-qzm9wgde	478	19	early	early	RB
cord-336510-qzm9wgde	478	20	in	in	IN
cord-336510-qzm9wgde	478	21	HSV	HSV	NNP
cord-336510-qzm9wgde	478	22	infections	infection	NNS
cord-336510-qzm9wgde	478	23	,	,	,
cord-336510-qzm9wgde	478	24	well	well	RB
cord-336510-qzm9wgde	478	25	before	before	IN
cord-336510-qzm9wgde	478	26	the	the	DT
cord-336510-qzm9wgde	478	27	production	production	NN
cord-336510-qzm9wgde	478	28	of	of	IN
cord-336510-qzm9wgde	478	29	IL-12	IL-12	NNP
cord-336510-qzm9wgde	478	30	,	,	,
cord-336510-qzm9wgde	478	31	has	have	VBZ
cord-336510-qzm9wgde	478	32	so	so	RB
cord-336510-qzm9wgde	478	33	far	far	RB
cord-336510-qzm9wgde	478	34	not	not	RB
cord-336510-qzm9wgde	478	35	been	be	VBN
cord-336510-qzm9wgde	478	36	elucidated	elucidate	VBN
cord-336510-qzm9wgde	478	37	.	.	.
cord-336510-qzm9wgde	479	1	As	as	IN
cord-336510-qzm9wgde	479	2	described	describe	VBN
cord-336510-qzm9wgde	479	3	earlier	early	RBR
cord-336510-qzm9wgde	479	4	,	,	,
cord-336510-qzm9wgde	479	5	the	the	DT
cord-336510-qzm9wgde	479	6	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	479	7	induction	induction	NN
cord-336510-qzm9wgde	479	8	is	be	VBZ
cord-336510-qzm9wgde	479	9	influenced	influence	VBN
cord-336510-qzm9wgde	479	10	by	by	IN
cord-336510-qzm9wgde	479	11	IFN	IFN	NNP
cord-336510-qzm9wgde	479	12	-	-	HYPH
cord-336510-qzm9wgde	479	13	γ	γ	NNP
cord-336510-qzm9wgde	479	14	in	in	IN
cord-336510-qzm9wgde	479	15	a	a	DT
cord-336510-qzm9wgde	479	16	positive	positive	JJ
cord-336510-qzm9wgde	479	17	feed	feed	NN
cord-336510-qzm9wgde	479	18	back	back	RB
cord-336510-qzm9wgde	479	19	loop	loop	NN
cord-336510-qzm9wgde	479	20	.	.	.
cord-336510-qzm9wgde	480	1	IFN	IFN	NNP
cord-336510-qzm9wgde	480	2	-	-	HYPH
cord-336510-qzm9wgde	480	3	γ	γ	NNP
cord-336510-qzm9wgde	480	4	could	could	MD
cord-336510-qzm9wgde	480	5	activate	activate	VB
cord-336510-qzm9wgde	480	6	IL-12	IL-12	NNP
cord-336510-qzm9wgde	480	7	transcription	transcription	NN
cord-336510-qzm9wgde	480	8	through	through	IN
cord-336510-qzm9wgde	480	9	binding	binding	NN
cord-336510-qzm9wgde	480	10	of	of	IN
cord-336510-qzm9wgde	480	11	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	480	12	,	,	,
cord-336510-qzm9wgde	480	13	-2	-2	NNP
cord-336510-qzm9wgde	480	14	,	,	,
cord-336510-qzm9wgde	480	15	and	and	CC
cord-336510-qzm9wgde	480	16	-8	-8	VBG
cord-336510-qzm9wgde	480	17	to	to	IN
cord-336510-qzm9wgde	480	18	an	an	DT
cord-336510-qzm9wgde	480	19	ISRE	ISRE	NNP
cord-336510-qzm9wgde	480	20	site	site	NN
cord-336510-qzm9wgde	480	21	in	in	IN
cord-336510-qzm9wgde	480	22	the	the	DT
cord-336510-qzm9wgde	480	23	promoter	promoter	NN
cord-336510-qzm9wgde	480	24	-	-	HYPH
cord-336510-qzm9wgde	480	25	region	region	NN
cord-336510-qzm9wgde	480	26	of	of	IN
cord-336510-qzm9wgde	480	27	IL-12	IL-12	NNP
cord-336510-qzm9wgde	480	28	[	[	-LRB-
cord-336510-qzm9wgde	480	29	373	373	CD
cord-336510-qzm9wgde	480	30	,	,	,
cord-336510-qzm9wgde	480	31	374	374	CD
cord-336510-qzm9wgde	480	32	]	]	-RRB-
cord-336510-qzm9wgde	480	33	.	.	.
cord-336510-qzm9wgde	481	1	Upon	upon	IN
cord-336510-qzm9wgde	481	2	HSV	HSV	NNP
cord-336510-qzm9wgde	481	3	infection	infection	NN
cord-336510-qzm9wgde	481	4	,	,	,
cord-336510-qzm9wgde	481	5	IFN	IFN	NNP
cord-336510-qzm9wgde	481	6	-	-	HYPH
cord-336510-qzm9wgde	481	7	γ	γ	NNP
cord-336510-qzm9wgde	481	8	is	be	VBZ
cord-336510-qzm9wgde	481	9	produced	produce	VBN
cord-336510-qzm9wgde	481	10	as	as	IN
cord-336510-qzm9wgde	481	11	part	part	NN
cord-336510-qzm9wgde	481	12	of	of	IN
cord-336510-qzm9wgde	481	13	the	the	DT
cord-336510-qzm9wgde	481	14	nonspecific	nonspecific	JJ
cord-336510-qzm9wgde	481	15	response	response	NN
cord-336510-qzm9wgde	481	16	to	to	IN
cord-336510-qzm9wgde	481	17	the	the	DT
cord-336510-qzm9wgde	481	18	virus	virus	NN
cord-336510-qzm9wgde	481	19	.	.	.
cord-336510-qzm9wgde	482	1	A	a	DT
cord-336510-qzm9wgde	482	2	marked	marked	JJ
cord-336510-qzm9wgde	482	3	synergism	synergism	NN
cord-336510-qzm9wgde	482	4	between	between	IN
cord-336510-qzm9wgde	482	5	HSV	HSV	NNP
cord-336510-qzm9wgde	482	6	and	and	CC
cord-336510-qzm9wgde	482	7	IFN	IFN	NNP
cord-336510-qzm9wgde	482	8	-	-	HYPH
cord-336510-qzm9wgde	482	9	γ	γ	NN
cord-336510-qzm9wgde	482	10	in	in	IN
cord-336510-qzm9wgde	482	11	IL-12	IL-12	NNP
cord-336510-qzm9wgde	482	12	induction	induction	NN
cord-336510-qzm9wgde	482	13	has	have	VBZ
cord-336510-qzm9wgde	482	14	been	be	VBN
cord-336510-qzm9wgde	482	15	demonstrated	demonstrate	VBN
cord-336510-qzm9wgde	482	16	[	[	-LRB-
cord-336510-qzm9wgde	482	17	238	238	CD
cord-336510-qzm9wgde	482	18	]	]	-RRB-
cord-336510-qzm9wgde	482	19	,	,	,
cord-336510-qzm9wgde	482	20	indicating	indicate	VBG
cord-336510-qzm9wgde	482	21	that	that	IN
cord-336510-qzm9wgde	482	22	the	the	DT
cord-336510-qzm9wgde	482	23	IL-12	IL-12	NNP
cord-336510-qzm9wgde	482	24	/	/	SYM
cord-336510-qzm9wgde	482	25	IFN	IFN	NNP
cord-336510-qzm9wgde	482	26	-	-	HYPH
cord-336510-qzm9wgde	482	27	γ	γ	NNP
cord-336510-qzm9wgde	482	28	autoaccelerating	autoaccelerating	NN
cord-336510-qzm9wgde	482	29	system	system	NN
cord-336510-qzm9wgde	482	30	is	be	VBZ
cord-336510-qzm9wgde	482	31	of	of	IN
cord-336510-qzm9wgde	482	32	importance	importance	NN
cord-336510-qzm9wgde	482	33	during	during	IN
cord-336510-qzm9wgde	482	34	HSV	HSV	NNP
cord-336510-qzm9wgde	482	35	infections	infection	NNS
cord-336510-qzm9wgde	482	36	.	.	.
cord-336510-qzm9wgde	483	1	The	the	DT
cord-336510-qzm9wgde	483	2	IFN	IFN	NNP
cord-336510-qzm9wgde	483	3	-	-	HYPH
cord-336510-qzm9wgde	483	4	γ	γ	NN
cord-336510-qzm9wgde	483	5	-	-	HYPH
cord-336510-qzm9wgde	483	6	inducing	induce	VBG
cord-336510-qzm9wgde	483	7	activity	activity	NN
cord-336510-qzm9wgde	483	8	of	of	IN
cord-336510-qzm9wgde	483	9	the	the	DT
cord-336510-qzm9wgde	483	10	produced	produce	VBN
cord-336510-qzm9wgde	483	11	IL-12	IL-12	NNP
cord-336510-qzm9wgde	483	12	is	be	VBZ
cord-336510-qzm9wgde	483	13	pronounced	pronounce	VBN
cord-336510-qzm9wgde	483	14	in	in	IN
cord-336510-qzm9wgde	483	15	mouse	mouse	NN
cord-336510-qzm9wgde	483	16	peritoneal	peritoneal	NN
cord-336510-qzm9wgde	483	17	cells	cell	NNS
cord-336510-qzm9wgde	483	18	after	after	IN
cord-336510-qzm9wgde	483	19	24	24	CD
cord-336510-qzm9wgde	483	20	hours	hour	NNS
cord-336510-qzm9wgde	483	21	of	of	IN
cord-336510-qzm9wgde	483	22	infection	infection	NN
cord-336510-qzm9wgde	483	23	with	with	IN
cord-336510-qzm9wgde	483	24	HSV	HSV	NNP
cord-336510-qzm9wgde	483	25	[	[	-LRB-
cord-336510-qzm9wgde	483	26	238	238	CD
cord-336510-qzm9wgde	483	27	]	]	-RRB-
cord-336510-qzm9wgde	483	28	.	.	.
cord-336510-qzm9wgde	484	1	In	in	IN
cord-336510-qzm9wgde	484	2	a	a	DT
cord-336510-qzm9wgde	484	3	study	study	NN
cord-336510-qzm9wgde	484	4	by	by	IN
cord-336510-qzm9wgde	484	5	Kirchner	Kirchner	NNP
cord-336510-qzm9wgde	484	6	et	et	NNP
cord-336510-qzm9wgde	484	7	al	al	NNP
cord-336510-qzm9wgde	484	8	.	.	.
cord-336510-qzm9wgde	485	1	IFN	IFN	NNP
cord-336510-qzm9wgde	485	2	-	-	HYPH
cord-336510-qzm9wgde	485	3	γ	γ	NNP
cord-336510-qzm9wgde	485	4	was	be	VBD
cord-336510-qzm9wgde	485	5	detected	detect	VBN
cord-336510-qzm9wgde	485	6	as	as	RB
cord-336510-qzm9wgde	485	7	early	early	RB
cord-336510-qzm9wgde	485	8	as	as	IN
cord-336510-qzm9wgde	485	9	on	on	IN
cord-336510-qzm9wgde	485	10	day	day	NN
cord-336510-qzm9wgde	485	11	3	3	CD
cord-336510-qzm9wgde	485	12	of	of	IN
cord-336510-qzm9wgde	485	13	in	in	IN
cord-336510-qzm9wgde	485	14	vivo	vivo	FW
cord-336510-qzm9wgde	485	15	HSV	HSV	NNP
cord-336510-qzm9wgde	485	16	infection	infection	NN
cord-336510-qzm9wgde	485	17	,	,	,
cord-336510-qzm9wgde	485	18	and	and	CC
cord-336510-qzm9wgde	485	19	the	the	DT
cord-336510-qzm9wgde	485	20	IFN	IFN	NNP
cord-336510-qzm9wgde	485	21	-	-	HYPH
cord-336510-qzm9wgde	485	22	γ	γ	NNP
cord-336510-qzm9wgde	485	23	production	production	NN
cord-336510-qzm9wgde	485	24	was	be	VBD
cord-336510-qzm9wgde	485	25	correlated	correlate	VBN
cord-336510-qzm9wgde	485	26	to	to	IN
cord-336510-qzm9wgde	485	27	the	the	DT
cord-336510-qzm9wgde	485	28	genetics	genetic	NNS
cord-336510-qzm9wgde	485	29	of	of	IN
cord-336510-qzm9wgde	485	30	HSV	HSV	NNP
cord-336510-qzm9wgde	485	31	resistance	resistance	NN
cord-336510-qzm9wgde	485	32	[	[	-LRB-
cord-336510-qzm9wgde	485	33	375	375	CD
cord-336510-qzm9wgde	485	34	]	]	-RRB-
cord-336510-qzm9wgde	485	35	.	.	.
cord-336510-qzm9wgde	486	1	During	during	IN
cord-336510-qzm9wgde	486	2	HSV	HSV	NNP
cord-336510-qzm9wgde	486	3	infection	infection	NN
cord-336510-qzm9wgde	486	4	,	,	,
cord-336510-qzm9wgde	486	5	the	the	DT
cord-336510-qzm9wgde	486	6	production	production	NN
cord-336510-qzm9wgde	486	7	of	of	IN
cord-336510-qzm9wgde	486	8	IFN	IFN	NNP
cord-336510-qzm9wgde	486	9	-	-	HYPH
cord-336510-qzm9wgde	486	10	γ	γ	NNP
cord-336510-qzm9wgde	486	11	is	be	VBZ
cord-336510-qzm9wgde	486	12	mainly	mainly	RB
cord-336510-qzm9wgde	486	13	induced	induce	VBN
cord-336510-qzm9wgde	486	14	as	as	IN
cord-336510-qzm9wgde	486	15	a	a	DT
cord-336510-qzm9wgde	486	16	concerted	concerted	JJ
cord-336510-qzm9wgde	486	17	action	action	NN
cord-336510-qzm9wgde	486	18	of	of	IN
cord-336510-qzm9wgde	486	19	several	several	JJ
cord-336510-qzm9wgde	486	20	factors	factor	NNS
cord-336510-qzm9wgde	486	21	and	and	CC
cord-336510-qzm9wgde	486	22	not	not	RB
cord-336510-qzm9wgde	486	23	by	by	IN
cord-336510-qzm9wgde	486	24	IL-12	IL-12	NNP
cord-336510-qzm9wgde	486	25	alone	alone	RB
cord-336510-qzm9wgde	486	26	.	.	.
cord-336510-qzm9wgde	487	1	IFN	IFN	NNP
cord-336510-qzm9wgde	487	2	-	-	HYPH
cord-336510-qzm9wgde	487	3	α	α	NNP
cord-336510-qzm9wgde	487	4	/	/	SYM
cord-336510-qzm9wgde	487	5	β	β	NN
cord-336510-qzm9wgde	487	6	by	by	IN
cord-336510-qzm9wgde	487	7	itself	-PRON-	PRP
cord-336510-qzm9wgde	487	8	was	be	VBD
cord-336510-qzm9wgde	487	9	shown	show	VBN
cord-336510-qzm9wgde	487	10	to	to	TO
cord-336510-qzm9wgde	487	11	be	be	VB
cord-336510-qzm9wgde	487	12	a	a	DT
cord-336510-qzm9wgde	487	13	weak	weak	JJ
cord-336510-qzm9wgde	487	14	inducer	inducer	NN
cord-336510-qzm9wgde	487	15	of	of	IN
cord-336510-qzm9wgde	487	16	IFN	IFN	NNP
cord-336510-qzm9wgde	487	17	-	-	HYPH
cord-336510-qzm9wgde	487	18	γ	γ	NN
cord-336510-qzm9wgde	487	19	production	production	NN
cord-336510-qzm9wgde	487	20	by	by	IN
cord-336510-qzm9wgde	487	21	NK	NK	NNP
cord-336510-qzm9wgde	487	22	cells	cell	NNS
cord-336510-qzm9wgde	487	23	,	,	,
cord-336510-qzm9wgde	487	24	but	but	CC
cord-336510-qzm9wgde	487	25	in	in	IN
cord-336510-qzm9wgde	487	26	synergy	synergy	NN
cord-336510-qzm9wgde	487	27	with	with	IN
cord-336510-qzm9wgde	487	28	IL-12	IL-12	NNP
cord-336510-qzm9wgde	487	29	the	the	DT
cord-336510-qzm9wgde	487	30	production	production	NN
cord-336510-qzm9wgde	487	31	of	of	IN
cord-336510-qzm9wgde	487	32	IFNγ	IFNγ	NNS
cord-336510-qzm9wgde	487	33	was	be	VBD
cord-336510-qzm9wgde	487	34	markedly	markedly	RB
cord-336510-qzm9wgde	487	35	enhanced	enhance	VBN
cord-336510-qzm9wgde	487	36	[	[	-LRB-
cord-336510-qzm9wgde	487	37	376	376	CD
cord-336510-qzm9wgde	487	38	]	]	-RRB-
cord-336510-qzm9wgde	487	39	.	.	.
cord-336510-qzm9wgde	488	1	In	in	IN
cord-336510-qzm9wgde	488	2	elicited	elicit	VBN
cord-336510-qzm9wgde	488	3	peritoneal	peritoneal	JJ
cord-336510-qzm9wgde	488	4	macrophages	macrophage	NNS
cord-336510-qzm9wgde	488	5	,	,	,
cord-336510-qzm9wgde	488	6	HSV	HSV	NNP
cord-336510-qzm9wgde	488	7	induced	induce	VBD
cord-336510-qzm9wgde	488	8	efficient	efficient	JJ
cord-336510-qzm9wgde	488	9	IFN	IFN	NNP
cord-336510-qzm9wgde	488	10	-	-	HYPH
cord-336510-qzm9wgde	488	11	γ	γ	NN
cord-336510-qzm9wgde	488	12	production	production	NN
cord-336510-qzm9wgde	488	13	through	through	IN
cord-336510-qzm9wgde	488	14	cooperation	cooperation	NN
cord-336510-qzm9wgde	488	15	of	of	IN
cord-336510-qzm9wgde	488	16	IL-12	IL-12	NNP
cord-336510-qzm9wgde	488	17	,	,	,
cord-336510-qzm9wgde	488	18	IFN	IFN	NNP
cord-336510-qzm9wgde	488	19	-	-	HYPH
cord-336510-qzm9wgde	488	20	α	α	NNP
cord-336510-qzm9wgde	488	21	/	/	SYM
cord-336510-qzm9wgde	488	22	β	β	NN
cord-336510-qzm9wgde	488	23	and	and	CC
cord-336510-qzm9wgde	488	24	IL-18	IL-18	NNP
cord-336510-qzm9wgde	488	25	[	[	-LRB-
cord-336510-qzm9wgde	488	26	377	377	CD
cord-336510-qzm9wgde	488	27	]	]	-RRB-
cord-336510-qzm9wgde	488	28	.	.	.
cord-336510-qzm9wgde	489	1	In	in	IN
cord-336510-qzm9wgde	489	2	such	such	PDT
cord-336510-qzm9wgde	489	3	a	a	DT
cord-336510-qzm9wgde	489	4	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	489	5	environment	environment	NN
cord-336510-qzm9wgde	489	6	even	even	RB
cord-336510-qzm9wgde	489	7	other	other	JJ
cord-336510-qzm9wgde	489	8	cells	cell	NNS
cord-336510-qzm9wgde	489	9	than	than	IN
cord-336510-qzm9wgde	489	10	NK	NK	NNP
cord-336510-qzm9wgde	489	11	and	and	CC
cord-336510-qzm9wgde	489	12	T	T	NNP
cord-336510-qzm9wgde	489	13	cells	cell	NNS
cord-336510-qzm9wgde	489	14	,	,	,
cord-336510-qzm9wgde	489	15	e.g.	e.g.	RB
cord-336510-qzm9wgde	489	16	macrophages	macrophage	NNS
cord-336510-qzm9wgde	489	17	,	,	,
cord-336510-qzm9wgde	489	18	might	may	MD
cord-336510-qzm9wgde	489	19	produce	produce	VB
cord-336510-qzm9wgde	489	20	lower	low	JJR
cord-336510-qzm9wgde	489	21	levels	level	NNS
cord-336510-qzm9wgde	489	22	of	of	IN
cord-336510-qzm9wgde	489	23	IFN	IFN	NNP
cord-336510-qzm9wgde	489	24	-	-	HYPH
cord-336510-qzm9wgde	489	25	γ	γ	NNP
cord-336510-qzm9wgde	489	26	[	[	-LRB-
cord-336510-qzm9wgde	489	27	200	200	CD
cord-336510-qzm9wgde	489	28	,	,	,
cord-336510-qzm9wgde	489	29	202	202	CD
cord-336510-qzm9wgde	489	30	,	,	,
cord-336510-qzm9wgde	489	31	245	245	CD
cord-336510-qzm9wgde	489	32	]	]	-RRB-
cord-336510-qzm9wgde	489	33	.	.	.
cord-336510-qzm9wgde	490	1	IL-12	IL-12	NNP
cord-336510-qzm9wgde	490	2	signals	signal	NNS
cord-336510-qzm9wgde	490	3	through	through	IN
cord-336510-qzm9wgde	490	4	STAT4	stat4	NN
cord-336510-qzm9wgde	490	5	,	,	,
cord-336510-qzm9wgde	490	6	but	but	CC
cord-336510-qzm9wgde	490	7	STAT4	stat4	NN
cord-336510-qzm9wgde	490	8	translocation	translocation	NN
cord-336510-qzm9wgde	490	9	to	to	IN
cord-336510-qzm9wgde	490	10	the	the	DT
cord-336510-qzm9wgde	490	11	nucleus	nucleus	NN
cord-336510-qzm9wgde	490	12	of	of	IN
cord-336510-qzm9wgde	490	13	NK	NK	NNP
cord-336510-qzm9wgde	490	14	cells	cell	NNS
cord-336510-qzm9wgde	490	15	has	have	VBZ
cord-336510-qzm9wgde	490	16	also	also	RB
cord-336510-qzm9wgde	490	17	been	be	VBN
cord-336510-qzm9wgde	490	18	seen	see	VBN
cord-336510-qzm9wgde	490	19	after	after	IN
cord-336510-qzm9wgde	490	20	IFN	IFN	NNP
cord-336510-qzm9wgde	490	21	-	-	HYPH
cord-336510-qzm9wgde	490	22	α	α	NNP
cord-336510-qzm9wgde	490	23	/	/	SYM
cord-336510-qzm9wgde	490	24	β	β	NN
cord-336510-qzm9wgde	490	25	stimulation	stimulation	NN
cord-336510-qzm9wgde	490	26	[	[	-LRB-
cord-336510-qzm9wgde	490	27	206	206	CD
cord-336510-qzm9wgde	490	28	,	,	,
cord-336510-qzm9wgde	490	29	378	378	CD
cord-336510-qzm9wgde	490	30	]	]	-RRB-
cord-336510-qzm9wgde	490	31	.	.	.
cord-336510-qzm9wgde	491	1	Likewise	likewise	RB
cord-336510-qzm9wgde	491	2	,	,	,
cord-336510-qzm9wgde	491	3	IFN	IFN	NNP
cord-336510-qzm9wgde	491	4	-	-	HYPH
cord-336510-qzm9wgde	491	5	α	α	NNP
cord-336510-qzm9wgde	491	6	/	/	SYM
cord-336510-qzm9wgde	491	7	β	β	NN
cord-336510-qzm9wgde	491	8	induces	induce	VBZ
cord-336510-qzm9wgde	491	9	STAT4	stat4	NN
cord-336510-qzm9wgde	491	10	phosphorylation	phosphorylation	NN
cord-336510-qzm9wgde	491	11	in	in	IN
cord-336510-qzm9wgde	491	12	T	t	NN
cord-336510-qzm9wgde	491	13	cells	cell	NNS
cord-336510-qzm9wgde	491	14	[	[	-LRB-
cord-336510-qzm9wgde	491	15	379	379	CD
cord-336510-qzm9wgde	491	16	]	]	-RRB-
cord-336510-qzm9wgde	491	17	,	,	,
cord-336510-qzm9wgde	491	18	indicating	indicate	VBG
cord-336510-qzm9wgde	491	19	that	that	IN
cord-336510-qzm9wgde	491	20	IL-12	IL-12	NNP
cord-336510-qzm9wgde	491	21	and	and	CC
cord-336510-qzm9wgde	491	22	IFN	IFN	NNP
cord-336510-qzm9wgde	491	23	-	-	HYPH
cord-336510-qzm9wgde	491	24	α	α	NNP
cord-336510-qzm9wgde	491	25	/	/	SYM
cord-336510-qzm9wgde	491	26	β	β	NN
cord-336510-qzm9wgde	491	27	at	at	IN
cord-336510-qzm9wgde	491	28	this	this	DT
cord-336510-qzm9wgde	491	29	point	point	NN
cord-336510-qzm9wgde	491	30	act	act	NN
cord-336510-qzm9wgde	491	31	through	through	IN
cord-336510-qzm9wgde	491	32	a	a	DT
cord-336510-qzm9wgde	491	33	shared	share	VBN
cord-336510-qzm9wgde	491	34	signalling	signal	VBG
cord-336510-qzm9wgde	491	35	pathway	pathway	NN
cord-336510-qzm9wgde	491	36	.	.	.
cord-336510-qzm9wgde	492	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	492	2	,	,	,
cord-336510-qzm9wgde	492	3	the	the	DT
cord-336510-qzm9wgde	492	4	synergistic	synergistic	JJ
cord-336510-qzm9wgde	492	5	action	action	NN
cord-336510-qzm9wgde	492	6	of	of	IN
cord-336510-qzm9wgde	492	7	IL-12	IL-12	NNP
cord-336510-qzm9wgde	492	8	and	and	CC
cord-336510-qzm9wgde	492	9	IL-18	IL-18	NNP
cord-336510-qzm9wgde	492	10	in	in	IN
cord-336510-qzm9wgde	492	11	IFN	IFN	NNP
cord-336510-qzm9wgde	492	12	-	-	HYPH
cord-336510-qzm9wgde	492	13	γ	γ	NN
cord-336510-qzm9wgde	492	14	production	production	NN
cord-336510-qzm9wgde	492	15	by	by	IN
cord-336510-qzm9wgde	492	16	macrophages	macrophage	NNS
cord-336510-qzm9wgde	492	17	was	be	VBD
cord-336510-qzm9wgde	492	18	shown	show	VBN
cord-336510-qzm9wgde	492	19	to	to	TO
cord-336510-qzm9wgde	492	20	be	be	VB
cord-336510-qzm9wgde	492	21	dependent	dependent	JJ
cord-336510-qzm9wgde	492	22	on	on	IN
cord-336510-qzm9wgde	492	23	STAT4	stat4	NN
cord-336510-qzm9wgde	492	24	[	[	-LRB-
cord-336510-qzm9wgde	492	25	197	197	CD
cord-336510-qzm9wgde	492	26	]	]	-RRB-
cord-336510-qzm9wgde	492	27	.	.	.
cord-336510-qzm9wgde	493	1	In	in	IN
cord-336510-qzm9wgde	493	2	addition	addition	NN
cord-336510-qzm9wgde	493	3	to	to	IN
cord-336510-qzm9wgde	493	4	these	these	DT
cord-336510-qzm9wgde	493	5	factors	factor	NNS
cord-336510-qzm9wgde	493	6	,	,	,
cord-336510-qzm9wgde	493	7	TNF	TNF	NNP
cord-336510-qzm9wgde	493	8	and	and	CC
cord-336510-qzm9wgde	493	9	IL-1	IL-1	NNP
cord-336510-qzm9wgde	493	10	have	have	VBP
cord-336510-qzm9wgde	493	11	also	also	RB
cord-336510-qzm9wgde	493	12	been	be	VBN
cord-336510-qzm9wgde	493	13	shown	show	VBN
cord-336510-qzm9wgde	493	14	to	to	TO
cord-336510-qzm9wgde	493	15	act	act	VB
cord-336510-qzm9wgde	493	16	in	in	IN
cord-336510-qzm9wgde	493	17	synergy	synergy	NN
cord-336510-qzm9wgde	493	18	with	with	IN
cord-336510-qzm9wgde	493	19	IL-12	IL-12	NNP
cord-336510-qzm9wgde	493	20	in	in	IN
cord-336510-qzm9wgde	493	21	IFN	IFN	NNP
cord-336510-qzm9wgde	493	22	-	-	HYPH
cord-336510-qzm9wgde	493	23	γ	γ	NN
cord-336510-qzm9wgde	493	24	induction	induction	NN
cord-336510-qzm9wgde	493	25	[	[	-LRB-
cord-336510-qzm9wgde	493	26	206	206	CD
cord-336510-qzm9wgde	493	27	,	,	,
cord-336510-qzm9wgde	493	28	380	380	CD
cord-336510-qzm9wgde	493	29	,	,	,
cord-336510-qzm9wgde	493	30	381	381	CD
cord-336510-qzm9wgde	493	31	]	]	-RRB-
cord-336510-qzm9wgde	493	32	and	and	CC
cord-336510-qzm9wgde	493	33	vice	vice	NN
cord-336510-qzm9wgde	493	34	versa	versa	RB
cord-336510-qzm9wgde	493	35	,	,	,
cord-336510-qzm9wgde	493	36	IFN	IFN	NNP
cord-336510-qzm9wgde	493	37	-	-	HYPH
cord-336510-qzm9wgde	493	38	γ	γ	NNP
cord-336510-qzm9wgde	493	39	has	have	VBZ
cord-336510-qzm9wgde	493	40	been	be	VBN
cord-336510-qzm9wgde	493	41	shown	show	VBN
cord-336510-qzm9wgde	493	42	to	to	TO
cord-336510-qzm9wgde	493	43	synergize	synergize	VB
cord-336510-qzm9wgde	493	44	with	with	IN
cord-336510-qzm9wgde	493	45	HSV	HSV	NNP
cord-336510-qzm9wgde	493	46	in	in	IN
cord-336510-qzm9wgde	493	47	induction	induction	NN
cord-336510-qzm9wgde	493	48	of	of	IN
cord-336510-qzm9wgde	493	49	TNF	TNF	NNP
cord-336510-qzm9wgde	493	50	production	production	NN
cord-336510-qzm9wgde	493	51	[	[	-LRB-
cord-336510-qzm9wgde	493	52	325	325	CD
cord-336510-qzm9wgde	493	53	]	]	-RRB-
cord-336510-qzm9wgde	493	54	.	.	.
cord-336510-qzm9wgde	494	1	This	this	DT
cord-336510-qzm9wgde	494	2	further	further	RB
cord-336510-qzm9wgde	494	3	emphasizes	emphasize	VBZ
cord-336510-qzm9wgde	494	4	the	the	DT
cord-336510-qzm9wgde	494	5	concept	concept	NN
cord-336510-qzm9wgde	494	6	of	of	IN
cord-336510-qzm9wgde	494	7	positive	positive	JJ
cord-336510-qzm9wgde	494	8	feed	feed	NN
cord-336510-qzm9wgde	494	9	-	-	HYPH
cord-336510-qzm9wgde	494	10	back	back	NN
cord-336510-qzm9wgde	494	11	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	494	12	in	in	IN
cord-336510-qzm9wgde	494	13	the	the	DT
cord-336510-qzm9wgde	494	14	regulation	regulation	NN
cord-336510-qzm9wgde	494	15	of	of	IN
cord-336510-qzm9wgde	494	16	early	early	JJ
cord-336510-qzm9wgde	494	17	IFN	IFN	NNP
cord-336510-qzm9wgde	494	18	-	-	HYPH
cord-336510-qzm9wgde	494	19	γ	γ	NNP
cord-336510-qzm9wgde	494	20	production	production	NN
cord-336510-qzm9wgde	494	21	.	.	.
cord-336510-qzm9wgde	495	1	The	the	DT
cord-336510-qzm9wgde	495	2	important	important	JJ
cord-336510-qzm9wgde	495	3	direct	direct	JJ
cord-336510-qzm9wgde	495	4	effect	effect	NN
cord-336510-qzm9wgde	495	5	of	of	IN
cord-336510-qzm9wgde	495	6	IFN	IFN	NNP
cord-336510-qzm9wgde	495	7	-	-	HYPH
cord-336510-qzm9wgde	495	8	α	α	NNP
cord-336510-qzm9wgde	495	9	/	/	SYM
cord-336510-qzm9wgde	495	10	β	β	NN
cord-336510-qzm9wgde	495	11	on	on	IN
cord-336510-qzm9wgde	495	12	HSV	HSV	NNP
cord-336510-qzm9wgde	495	13	replication	replication	NN
cord-336510-qzm9wgde	495	14	was	be	VBD
cord-336510-qzm9wgde	495	15	found	find	VBN
cord-336510-qzm9wgde	495	16	to	to	TO
cord-336510-qzm9wgde	495	17	be	be	VB
cord-336510-qzm9wgde	495	18	enhanced	enhance	VBN
cord-336510-qzm9wgde	495	19	synergistically	synergistically	RB
cord-336510-qzm9wgde	495	20	by	by	IN
cord-336510-qzm9wgde	495	21	IFN	IFN	NNP
cord-336510-qzm9wgde	495	22	-	-	HYPH
cord-336510-qzm9wgde	495	23	γ	γ	NNP
cord-336510-qzm9wgde	495	24	in	in	IN
cord-336510-qzm9wgde	495	25	both	both	DT
cord-336510-qzm9wgde	495	26	cell	cell	NN
cord-336510-qzm9wgde	495	27	culture	culture	NN
cord-336510-qzm9wgde	495	28	and	and	CC
cord-336510-qzm9wgde	495	29	in	in	IN
cord-336510-qzm9wgde	495	30	vivo	vivo	NN
cord-336510-qzm9wgde	495	31	in	in	IN
cord-336510-qzm9wgde	495	32	mice	mouse	NNS
cord-336510-qzm9wgde	495	33	[	[	-LRB-
cord-336510-qzm9wgde	495	34	363	363	CD
cord-336510-qzm9wgde	495	35	,	,	,
cord-336510-qzm9wgde	495	36	[	[	-LRB-
cord-336510-qzm9wgde	495	37	382	382	CD
cord-336510-qzm9wgde	495	38	]	]	-RRB-
cord-336510-qzm9wgde	495	39	[	[	-LRB-
cord-336510-qzm9wgde	495	40	383	383	CD
cord-336510-qzm9wgde	495	41	]	]	-RRB-
cord-336510-qzm9wgde	495	42	[	[	-LRB-
cord-336510-qzm9wgde	495	43	384	384	CD
cord-336510-qzm9wgde	495	44	]	]	-RRB-
cord-336510-qzm9wgde	495	45	.	.	.
cord-336510-qzm9wgde	496	1	This	this	DT
cord-336510-qzm9wgde	496	2	is	be	VBZ
cord-336510-qzm9wgde	496	3	,	,	,
cord-336510-qzm9wgde	496	4	however	however	RB
cord-336510-qzm9wgde	496	5	,	,	,
cord-336510-qzm9wgde	496	6	in	in	IN
cord-336510-qzm9wgde	496	7	conflict	conflict	NN
cord-336510-qzm9wgde	496	8	with	with	IN
cord-336510-qzm9wgde	496	9	an	an	DT
cord-336510-qzm9wgde	496	10	early	early	JJ
cord-336510-qzm9wgde	496	11	study	study	NN
cord-336510-qzm9wgde	496	12	,	,	,
cord-336510-qzm9wgde	496	13	which	which	WDT
cord-336510-qzm9wgde	496	14	could	could	MD
cord-336510-qzm9wgde	496	15	not	not	RB
cord-336510-qzm9wgde	496	16	reveal	reveal	VB
cord-336510-qzm9wgde	496	17	any	any	DT
cord-336510-qzm9wgde	496	18	synergism	synergism	NN
cord-336510-qzm9wgde	496	19	between	between	IN
cord-336510-qzm9wgde	496	20	IFN	IFN	NNP
cord-336510-qzm9wgde	496	21	-	-	HYPH
cord-336510-qzm9wgde	496	22	α	α	NNP
cord-336510-qzm9wgde	496	23	/	/	SYM
cord-336510-qzm9wgde	496	24	β	β	NN
cord-336510-qzm9wgde	496	25	and	and	CC
cord-336510-qzm9wgde	496	26	IFN	IFN	NNP
cord-336510-qzm9wgde	496	27	-	-	HYPH
cord-336510-qzm9wgde	496	28	γ	γ	NNP
cord-336510-qzm9wgde	496	29	on	on	IN
cord-336510-qzm9wgde	496	30	the	the	DT
cord-336510-qzm9wgde	496	31	replication	replication	NN
cord-336510-qzm9wgde	496	32	of	of	IN
cord-336510-qzm9wgde	496	33	HSV	HSV	NNP
cord-336510-qzm9wgde	496	34	in	in	IN
cord-336510-qzm9wgde	496	35	human	human	JJ
cord-336510-qzm9wgde	496	36	blood	blood	NN
cord-336510-qzm9wgde	496	37	mononuclear	mononuclear	NN
cord-336510-qzm9wgde	496	38	cells	cell	NNS
cord-336510-qzm9wgde	496	39	[	[	-LRB-
cord-336510-qzm9wgde	496	40	385	385	CD
cord-336510-qzm9wgde	496	41	]	]	-RRB-
cord-336510-qzm9wgde	496	42	.	.	.
cord-336510-qzm9wgde	497	1	Synergistic	synergistic	JJ
cord-336510-qzm9wgde	497	2	action	action	NN
cord-336510-qzm9wgde	497	3	of	of	IN
cord-336510-qzm9wgde	497	4	the	the	DT
cord-336510-qzm9wgde	497	5	two	two	CD
cord-336510-qzm9wgde	497	6	types	type	NNS
cord-336510-qzm9wgde	497	7	of	of	IN
cord-336510-qzm9wgde	497	8	IFN	IFN	NNP
cord-336510-qzm9wgde	497	9	is	be	VBZ
cord-336510-qzm9wgde	497	10	further	further	RB
cord-336510-qzm9wgde	497	11	supported	support	VBN
cord-336510-qzm9wgde	497	12	by	by	IN
cord-336510-qzm9wgde	497	13	the	the	DT
cord-336510-qzm9wgde	497	14	observation	observation	NN
cord-336510-qzm9wgde	497	15	of	of	IN
cord-336510-qzm9wgde	497	16	synergism	synergism	NN
cord-336510-qzm9wgde	497	17	between	between	IN
cord-336510-qzm9wgde	497	18	IFN	IFN	NNP
cord-336510-qzm9wgde	497	19	-	-	HYPH
cord-336510-qzm9wgde	497	20	γ	γ	NNP
cord-336510-qzm9wgde	497	21	and	and	CC
cord-336510-qzm9wgde	497	22	TNF	TNF	NNP
cord-336510-qzm9wgde	497	23	on	on	IN
cord-336510-qzm9wgde	497	24	HSV	HSV	NNP
cord-336510-qzm9wgde	497	25	replication	replication	NN
cord-336510-qzm9wgde	497	26	in	in	IN
cord-336510-qzm9wgde	497	27	corneal	corneal	JJ
cord-336510-qzm9wgde	497	28	cells	cell	NNS
cord-336510-qzm9wgde	497	29	,	,	,
cord-336510-qzm9wgde	497	30	and	and	CC
cord-336510-qzm9wgde	497	31	the	the	DT
cord-336510-qzm9wgde	497	32	fact	fact	NN
cord-336510-qzm9wgde	497	33	that	that	IN
cord-336510-qzm9wgde	497	34	this	this	DT
cord-336510-qzm9wgde	497	35	was	be	VBD
cord-336510-qzm9wgde	497	36	exerted	exert	VBN
cord-336510-qzm9wgde	497	37	through	through	IN
cord-336510-qzm9wgde	497	38	production	production	NN
cord-336510-qzm9wgde	497	39	of	of	IN
cord-336510-qzm9wgde	497	40	IFN	IFN	NNP
cord-336510-qzm9wgde	497	41	-	-	HYPH
cord-336510-qzm9wgde	497	42	β	β	NNP
cord-336510-qzm9wgde	497	43	[	[	-LRB-
cord-336510-qzm9wgde	497	44	386	386	CD
cord-336510-qzm9wgde	497	45	]	]	-RRB-
cord-336510-qzm9wgde	497	46	[	[	-LRB-
cord-336510-qzm9wgde	497	47	387	387	CD
cord-336510-qzm9wgde	497	48	]	]	-RRB-
cord-336510-qzm9wgde	497	49	[	[	-LRB-
cord-336510-qzm9wgde	497	50	388	388	CD
cord-336510-qzm9wgde	497	51	]	]	-RRB-
cord-336510-qzm9wgde	497	52	.	.	.
cord-336510-qzm9wgde	498	1	The	the	DT
cord-336510-qzm9wgde	498	2	effect	effect	NN
cord-336510-qzm9wgde	498	3	was	be	VBD
cord-336510-qzm9wgde	498	4	,	,	,
cord-336510-qzm9wgde	498	5	however	however	RB
cord-336510-qzm9wgde	498	6	,	,	,
cord-336510-qzm9wgde	498	7	greatly	greatly	RB
cord-336510-qzm9wgde	498	8	dependent	dependent	JJ
cord-336510-qzm9wgde	498	9	on	on	IN
cord-336510-qzm9wgde	498	10	the	the	DT
cord-336510-qzm9wgde	498	11	cell	cell	NN
cord-336510-qzm9wgde	498	12	type	type	NN
cord-336510-qzm9wgde	498	13	examined	examine	VBN
cord-336510-qzm9wgde	498	14	,	,	,
cord-336510-qzm9wgde	498	15	which	which	WDT
cord-336510-qzm9wgde	498	16	could	could	MD
cord-336510-qzm9wgde	498	17	explain	explain	VB
cord-336510-qzm9wgde	498	18	the	the	DT
cord-336510-qzm9wgde	498	19	above	above	RB
cord-336510-qzm9wgde	498	20	-	-	HYPH
cord-336510-qzm9wgde	498	21	mentioned	mention	VBN
cord-336510-qzm9wgde	498	22	inconsistency	inconsistency	NN
cord-336510-qzm9wgde	498	23	.	.	.
cord-336510-qzm9wgde	499	1	Synergism	synergism	NN
cord-336510-qzm9wgde	499	2	between	between	IN
cord-336510-qzm9wgde	499	3	TNF	TNF	NNP
cord-336510-qzm9wgde	499	4	and	and	CC
cord-336510-qzm9wgde	499	5	IFN	IFN	NNP
cord-336510-qzm9wgde	499	6	-	-	HYPH
cord-336510-qzm9wgde	499	7	γ	γ	NN
cord-336510-qzm9wgde	499	8	in	in	IN
cord-336510-qzm9wgde	499	9	inhibition	inhibition	NN
cord-336510-qzm9wgde	499	10	of	of	IN
cord-336510-qzm9wgde	499	11	HSV	HSV	NNP
cord-336510-qzm9wgde	499	12	replication	replication	NN
cord-336510-qzm9wgde	499	13	has	have	VBZ
cord-336510-qzm9wgde	499	14	now	now	RB
cord-336510-qzm9wgde	499	15	been	be	VBN
cord-336510-qzm9wgde	499	16	shown	show	VBN
cord-336510-qzm9wgde	499	17	to	to	TO
cord-336510-qzm9wgde	499	18	be	be	VB
cord-336510-qzm9wgde	499	19	mediated	mediate	VBN
cord-336510-qzm9wgde	499	20	by	by	IN
cord-336510-qzm9wgde	499	21	activation	activation	NN
cord-336510-qzm9wgde	499	22	of	of	IN
cord-336510-qzm9wgde	499	23	a	a	DT
cord-336510-qzm9wgde	499	24	tryptophan	tryptophan	NN
cord-336510-qzm9wgde	499	25	-	-	HYPH
cord-336510-qzm9wgde	499	26	depleting	deplete	VBG
cord-336510-qzm9wgde	499	27	enzyme	enzyme	NN
cord-336510-qzm9wgde	499	28	[	[	-LRB-
cord-336510-qzm9wgde	499	29	389	389	CD
cord-336510-qzm9wgde	499	30	]	]	-RRB-
cord-336510-qzm9wgde	499	31	.	.	.
cord-336510-qzm9wgde	500	1	Thus	thus	RB
cord-336510-qzm9wgde	500	2	,	,	,
cord-336510-qzm9wgde	500	3	relatively	relatively	RB
cord-336510-qzm9wgde	500	4	small	small	JJ
cord-336510-qzm9wgde	500	5	amounts	amount	NNS
cord-336510-qzm9wgde	500	6	of	of	IN
cord-336510-qzm9wgde	500	7	early	early	JJ
cord-336510-qzm9wgde	500	8	IFN	IFN	NNP
cord-336510-qzm9wgde	500	9	-	-	HYPH
cord-336510-qzm9wgde	500	10	γ	γ	NNP
cord-336510-qzm9wgde	500	11	produced	produce	VBN
cord-336510-qzm9wgde	500	12	by	by	IN
cord-336510-qzm9wgde	500	13	NK	NK	NNP
cord-336510-qzm9wgde	500	14	cells	cell	NNS
cord-336510-qzm9wgde	500	15	in	in	IN
cord-336510-qzm9wgde	500	16	response	response	NN
cord-336510-qzm9wgde	500	17	to	to	IN
cord-336510-qzm9wgde	500	18	IL-12	IL-12	NNP
cord-336510-qzm9wgde	500	19	,	,	,
cord-336510-qzm9wgde	500	20	IFN	IFN	NNP
cord-336510-qzm9wgde	500	21	-	-	HYPH
cord-336510-qzm9wgde	500	22	α	α	NNP
cord-336510-qzm9wgde	500	23	/	/	SYM
cord-336510-qzm9wgde	500	24	β	β	NN
cord-336510-qzm9wgde	500	25	,	,	,
cord-336510-qzm9wgde	500	26	TNF	TNF	NNP
cord-336510-qzm9wgde	500	27	,	,	,
cord-336510-qzm9wgde	500	28	and	and	CC
cord-336510-qzm9wgde	500	29	IL-18	IL-18	NNP
cord-336510-qzm9wgde	500	30	could	could	MD
cord-336510-qzm9wgde	500	31	in	in	IN
cord-336510-qzm9wgde	500	32	collaboration	collaboration	NN
cord-336510-qzm9wgde	500	33	with	with	IN
cord-336510-qzm9wgde	500	34	the	the	DT
cord-336510-qzm9wgde	500	35	already	already	RB
cord-336510-qzm9wgde	500	36	present	present	JJ
cord-336510-qzm9wgde	500	37	IFN	IFN	NNP
cord-336510-qzm9wgde	500	38	-	-	HYPH
cord-336510-qzm9wgde	500	39	α	α	NNP
cord-336510-qzm9wgde	500	40	/	/	SYM
cord-336510-qzm9wgde	500	41	β	β	NN
cord-336510-qzm9wgde	500	42	and	and	CC
cord-336510-qzm9wgde	500	43	TNF	TNF	NNP
cord-336510-qzm9wgde	500	44	have	have	VBP
cord-336510-qzm9wgde	500	45	important	important	JJ
cord-336510-qzm9wgde	500	46	local	local	JJ
cord-336510-qzm9wgde	500	47	effect	effect	NN
cord-336510-qzm9wgde	500	48	on	on	IN
cord-336510-qzm9wgde	500	49	HSV	HSV	NNP
cord-336510-qzm9wgde	500	50	replication	replication	NN
cord-336510-qzm9wgde	500	51	in	in	IN
cord-336510-qzm9wgde	500	52	permissive	permissive	JJ
cord-336510-qzm9wgde	500	53	cells	cell	NNS
cord-336510-qzm9wgde	500	54	(	(	-LRB-
cord-336510-qzm9wgde	500	55	fig	fig	NN
cord-336510-qzm9wgde	500	56	.	.	.
cord-336510-qzm9wgde	500	57	3	3	CD
cord-336510-qzm9wgde	500	58	)	)	-RRB-
cord-336510-qzm9wgde	500	59	.	.	.
cord-336510-qzm9wgde	501	1	This	this	DT
cord-336510-qzm9wgde	501	2	conclusion	conclusion	NN
cord-336510-qzm9wgde	501	3	is	be	VBZ
cord-336510-qzm9wgde	501	4	further	further	RB
cord-336510-qzm9wgde	501	5	supported	support	VBN
cord-336510-qzm9wgde	501	6	by	by	IN
cord-336510-qzm9wgde	501	7	observations	observation	NNS
cord-336510-qzm9wgde	501	8	in	in	IN
cord-336510-qzm9wgde	501	9	KO	KO	NNP
cord-336510-qzm9wgde	501	10	mice	mouse	NNS
cord-336510-qzm9wgde	501	11	,	,	,
cord-336510-qzm9wgde	501	12	indicating	indicate	VBG
cord-336510-qzm9wgde	501	13	that	that	IN
cord-336510-qzm9wgde	501	14	collaborated	collaborate	VBN
cord-336510-qzm9wgde	501	15	action	action	NN
cord-336510-qzm9wgde	501	16	of	of	IN
cord-336510-qzm9wgde	501	17	IFN	IFN	NNP
cord-336510-qzm9wgde	501	18	-	-	HYPH
cord-336510-qzm9wgde	501	19	α	α	NNP
cord-336510-qzm9wgde	501	20	/	/	SYM
cord-336510-qzm9wgde	501	21	β	β	NN
cord-336510-qzm9wgde	501	22	and	and	CC
cord-336510-qzm9wgde	501	23	IFN	IFN	NNP
cord-336510-qzm9wgde	501	24	-	-	HYPH
cord-336510-qzm9wgde	501	25	γ	γ	NNP
cord-336510-qzm9wgde	501	26	is	be	VBZ
cord-336510-qzm9wgde	501	27	of	of	IN
cord-336510-qzm9wgde	501	28	importance	importance	NN
cord-336510-qzm9wgde	501	29	in	in	IN
cord-336510-qzm9wgde	501	30	control	control	NN
cord-336510-qzm9wgde	501	31	of	of	IN
cord-336510-qzm9wgde	501	32	subcutaneous	subcutaneous	JJ
cord-336510-qzm9wgde	501	33	HSV	HSV	NNP
cord-336510-qzm9wgde	501	34	infections	infection	NNS
cord-336510-qzm9wgde	501	35	[	[	-LRB-
cord-336510-qzm9wgde	501	36	362	362	CD
cord-336510-qzm9wgde	501	37	]	]	-RRB-
cord-336510-qzm9wgde	501	38	.	.	.
cord-336510-qzm9wgde	502	1	In	in	IN
cord-336510-qzm9wgde	502	2	vivo	vivo	NNP
cord-336510-qzm9wgde	502	3	studies	study	NNS
cord-336510-qzm9wgde	502	4	on	on	IN
cord-336510-qzm9wgde	502	5	HSV	HSV	NNP
cord-336510-qzm9wgde	502	6	infections	infection	NNS
cord-336510-qzm9wgde	502	7	in	in	IN
cord-336510-qzm9wgde	502	8	immunodeficient	immunodeficient	JJ
cord-336510-qzm9wgde	502	9	,	,	,
cord-336510-qzm9wgde	502	10	KO	KO	NNP
cord-336510-qzm9wgde	502	11	,	,	,
cord-336510-qzm9wgde	502	12	and	and	CC
cord-336510-qzm9wgde	502	13	antibody	antibody	NN
cord-336510-qzm9wgde	502	14	-	-	HYPH
cord-336510-qzm9wgde	502	15	treated	treat	VBN
cord-336510-qzm9wgde	502	16	mice	mouse	NNS
cord-336510-qzm9wgde	502	17	have	have	VBP
cord-336510-qzm9wgde	502	18	shown	show	VBN
cord-336510-qzm9wgde	502	19	that	that	IN
cord-336510-qzm9wgde	502	20	the	the	DT
cord-336510-qzm9wgde	502	21	IL-12	IL-12	NNP
cord-336510-qzm9wgde	502	22	,	,	,
cord-336510-qzm9wgde	502	23	Second	second	JJ
cord-336510-qzm9wgde	502	24	early	early	JJ
cord-336510-qzm9wgde	502	25	wave	wave	NN
cord-336510-qzm9wgde	502	26	of	of	IN
cord-336510-qzm9wgde	502	27	response	response	NN
cord-336510-qzm9wgde	502	28	Figure	figure	NN
cord-336510-qzm9wgde	502	29	3	3	CD
cord-336510-qzm9wgde	502	30	Second	Second	NNP
cord-336510-qzm9wgde	502	31	early	early	JJ
cord-336510-qzm9wgde	502	32	wave	wave	NN
cord-336510-qzm9wgde	502	33	of	of	IN
cord-336510-qzm9wgde	502	34	response	response	NN
cord-336510-qzm9wgde	502	35	.	.	.
cord-336510-qzm9wgde	503	1	Regulatory	regulatory	JJ
cord-336510-qzm9wgde	503	2	pathways	pathway	NNS
cord-336510-qzm9wgde	503	3	controlling	control	VBG
cord-336510-qzm9wgde	503	4	production	production	NN
cord-336510-qzm9wgde	503	5	and	and	CC
cord-336510-qzm9wgde	503	6	action	action	NN
cord-336510-qzm9wgde	503	7	of	of	IN
cord-336510-qzm9wgde	503	8	IFN	IFN	NNP
cord-336510-qzm9wgde	503	9	-	-	HYPH
cord-336510-qzm9wgde	503	10	γ	γ	NNP
cord-336510-qzm9wgde	503	11	during	during	IN
cord-336510-qzm9wgde	503	12	early	early	JJ
cord-336510-qzm9wgde	503	13	HSV	HSV	NNP
cord-336510-qzm9wgde	503	14	infection	infection	NN
cord-336510-qzm9wgde	503	15	.	.	.
cord-336510-qzm9wgde	504	1	When	when	WRB
cord-336510-qzm9wgde	504	2	infected	infect	VBN
cord-336510-qzm9wgde	504	3	with	with	IN
cord-336510-qzm9wgde	504	4	HSV	HSV	NNP
cord-336510-qzm9wgde	504	5	macrophages	macrophage	NNS
cord-336510-qzm9wgde	504	6	(	(	-LRB-
cord-336510-qzm9wgde	504	7	Mφ	Mφ	NNP
cord-336510-qzm9wgde	504	8	)	)	-RRB-
cord-336510-qzm9wgde	504	9	produce	produce	VB
cord-336510-qzm9wgde	504	10	several	several	JJ
cord-336510-qzm9wgde	504	11	cytokines	cytokine	NNS
cord-336510-qzm9wgde	504	12	,	,	,
cord-336510-qzm9wgde	504	13	including	include	VBG
cord-336510-qzm9wgde	504	14	IL-12	IL-12	NNP
cord-336510-qzm9wgde	504	15	,	,	,
cord-336510-qzm9wgde	504	16	which	which	WDT
cord-336510-qzm9wgde	504	17	stimulate	stimulate	VBP
cord-336510-qzm9wgde	504	18	production	production	NN
cord-336510-qzm9wgde	504	19	of	of	IN
cord-336510-qzm9wgde	504	20	IFN	IFN	NNP
cord-336510-qzm9wgde	504	21	-	-	HYPH
cord-336510-qzm9wgde	504	22	γ	γ	NNP
cord-336510-qzm9wgde	504	23	,	,	,
cord-336510-qzm9wgde	504	24	primarily	primarily	RB
cord-336510-qzm9wgde	504	25	in	in	IN
cord-336510-qzm9wgde	504	26	NK	NK	NNP
cord-336510-qzm9wgde	504	27	cells	cell	NNS
cord-336510-qzm9wgde	504	28	.	.	.
cord-336510-qzm9wgde	505	1	IFN	IFN	NNP
cord-336510-qzm9wgde	505	2	-	-	HYPH
cord-336510-qzm9wgde	505	3	γ	γ	NNP
cord-336510-qzm9wgde	505	4	then	then	RB
cord-336510-qzm9wgde	505	5	induces	induce	VBZ
cord-336510-qzm9wgde	505	6	NO	no	DT
cord-336510-qzm9wgde	505	7	production	production	NN
cord-336510-qzm9wgde	505	8	in	in	IN
cord-336510-qzm9wgde	505	9	macrophages	macrophage	NNS
cord-336510-qzm9wgde	505	10	and	and	CC
cord-336510-qzm9wgde	505	11	stimulate	stimulate	VB
cord-336510-qzm9wgde	505	12	the	the	DT
cord-336510-qzm9wgde	505	13	direct	direct	JJ
cord-336510-qzm9wgde	505	14	antiviral	antiviral	JJ
cord-336510-qzm9wgde	505	15	activity	activity	NN
cord-336510-qzm9wgde	505	16	of	of	IN
cord-336510-qzm9wgde	505	17	IFN	IFN	NNP
cord-336510-qzm9wgde	505	18	-	-	HYPH
cord-336510-qzm9wgde	505	19	α	α	NNP
cord-336510-qzm9wgde	505	20	/	/	SYM
cord-336510-qzm9wgde	505	21	β	β	NN
cord-336510-qzm9wgde	505	22	in	in	IN
cord-336510-qzm9wgde	505	23	other	other	JJ
cord-336510-qzm9wgde	505	24	cells	cell	NNS
cord-336510-qzm9wgde	505	25	.	.	.
cord-336510-qzm9wgde	506	1	Stimulatory	stimulatory	JJ
cord-336510-qzm9wgde	506	2	pathways	pathway	NNS
cord-336510-qzm9wgde	506	3	are	be	VBP
cord-336510-qzm9wgde	506	4	indicated	indicate	VBN
cord-336510-qzm9wgde	506	5	by	by	IN
cord-336510-qzm9wgde	506	6	green	green	JJ
cord-336510-qzm9wgde	506	7	arrows	arrow	NNS
cord-336510-qzm9wgde	506	8	(	(	-LRB-
cord-336510-qzm9wgde	506	9	→	→	NN
cord-336510-qzm9wgde	506	10	)	)	-RRB-
cord-336510-qzm9wgde	506	11	,	,	,
cord-336510-qzm9wgde	506	12	and	and	CC
cord-336510-qzm9wgde	506	13	inhibitory	inhibitory	JJ
cord-336510-qzm9wgde	506	14	pathways	pathway	NNS
cord-336510-qzm9wgde	506	15	are	be	VBP
cord-336510-qzm9wgde	506	16	drawn	draw	VBN
cord-336510-qzm9wgde	506	17	in	in	IN
cord-336510-qzm9wgde	506	18	red	red	NN
cord-336510-qzm9wgde	506	19	.	.	.
cord-336510-qzm9wgde	507	1	-23	-23	NNP
cord-336510-qzm9wgde	507	2	/	/	SYM
cord-336510-qzm9wgde	507	3	IFN	IFN	NNP
cord-336510-qzm9wgde	507	4	-	-	HYPH
cord-336510-qzm9wgde	507	5	γ	γ	NNP
cord-336510-qzm9wgde	507	6	system	system	NN
cord-336510-qzm9wgde	507	7	is	be	VBZ
cord-336510-qzm9wgde	507	8	able	able	JJ
cord-336510-qzm9wgde	507	9	to	to	TO
cord-336510-qzm9wgde	507	10	control	control	VB
cord-336510-qzm9wgde	507	11	the	the	DT
cord-336510-qzm9wgde	507	12	infection	infection	NN
cord-336510-qzm9wgde	507	13	,	,	,
cord-336510-qzm9wgde	507	14	affecting	affect	VBG
cord-336510-qzm9wgde	507	15	both	both	CC
cord-336510-qzm9wgde	507	16	the	the	DT
cord-336510-qzm9wgde	507	17	survival	survival	NN
cord-336510-qzm9wgde	507	18	rate	rate	NN
cord-336510-qzm9wgde	507	19	and	and	CC
cord-336510-qzm9wgde	507	20	the	the	DT
cord-336510-qzm9wgde	507	21	HSV	HSV	NNP
cord-336510-qzm9wgde	507	22	titres	titre	NNS
cord-336510-qzm9wgde	507	23	early	early	RB
cord-336510-qzm9wgde	507	24	in	in	IN
cord-336510-qzm9wgde	507	25	infection	infection	NN
cord-336510-qzm9wgde	507	26	[	[	-LRB-
cord-336510-qzm9wgde	507	27	390	390	CD
cord-336510-qzm9wgde	507	28	,	,	,
cord-336510-qzm9wgde	507	29	391	391	CD
cord-336510-qzm9wgde	507	30	]	]	-RRB-
cord-336510-qzm9wgde	507	31	.	.	.
cord-336510-qzm9wgde	508	1	The	the	DT
cord-336510-qzm9wgde	508	2	effect	effect	NN
cord-336510-qzm9wgde	508	3	of	of	IN
cord-336510-qzm9wgde	508	4	IL-12	IL-12	NNP
cord-336510-qzm9wgde	508	5	in	in	IN
cord-336510-qzm9wgde	508	6	HSV	HSV	NNP
cord-336510-qzm9wgde	508	7	infections	infection	NNS
cord-336510-qzm9wgde	508	8	seems	seem	VBZ
cord-336510-qzm9wgde	508	9	to	to	TO
cord-336510-qzm9wgde	508	10	be	be	VB
cord-336510-qzm9wgde	508	11	conducted	conduct	VBN
cord-336510-qzm9wgde	508	12	in	in	IN
cord-336510-qzm9wgde	508	13	synergy	synergy	NN
cord-336510-qzm9wgde	508	14	with	with	IN
cord-336510-qzm9wgde	508	15	IL-18	IL-18	NNP
cord-336510-qzm9wgde	508	16	[	[	-LRB-
cord-336510-qzm9wgde	508	17	390	390	CD
cord-336510-qzm9wgde	508	18	]	]	-RRB-
cord-336510-qzm9wgde	508	19	,	,	,
cord-336510-qzm9wgde	508	20	as	as	IN
cord-336510-qzm9wgde	508	21	it	-PRON-	PRP
cord-336510-qzm9wgde	508	22	has	have	VBZ
cord-336510-qzm9wgde	508	23	also	also	RB
cord-336510-qzm9wgde	508	24	been	be	VBN
cord-336510-qzm9wgde	508	25	shown	show	VBN
cord-336510-qzm9wgde	508	26	for	for	IN
cord-336510-qzm9wgde	508	27	vaccinia	vaccinia	NN
cord-336510-qzm9wgde	508	28	virus	virus	NN
cord-336510-qzm9wgde	508	29	[	[	-LRB-
cord-336510-qzm9wgde	508	30	392	392	CD
cord-336510-qzm9wgde	508	31	]	]	-RRB-
cord-336510-qzm9wgde	508	32	.	.	.
cord-336510-qzm9wgde	509	1	In	in	IN
cord-336510-qzm9wgde	509	2	HSV	HSV	NNP
cord-336510-qzm9wgde	509	3	corneal	corneal	JJ
cord-336510-qzm9wgde	509	4	infections	infection	NNS
cord-336510-qzm9wgde	509	5	in	in	IN
cord-336510-qzm9wgde	509	6	KO	KO	NNP
cord-336510-qzm9wgde	509	7	mice	mouse	NNS
cord-336510-qzm9wgde	509	8	,	,	,
cord-336510-qzm9wgde	509	9	IL-12	IL-12	NNP
cord-336510-qzm9wgde	509	10	was	be	VBD
cord-336510-qzm9wgde	509	11	shown	show	VBN
cord-336510-qzm9wgde	509	12	to	to	TO
cord-336510-qzm9wgde	509	13	participate	participate	VB
cord-336510-qzm9wgde	509	14	in	in	IN
cord-336510-qzm9wgde	509	15	the	the	DT
cord-336510-qzm9wgde	509	16	immune	immune	JJ
cord-336510-qzm9wgde	509	17	pathogenesis	pathogenesis	NN
cord-336510-qzm9wgde	509	18	[	[	-LRB-
cord-336510-qzm9wgde	509	19	393	393	CD
cord-336510-qzm9wgde	509	20	]	]	-RRB-
cord-336510-qzm9wgde	509	21	,	,	,
cord-336510-qzm9wgde	509	22	but	but	CC
cord-336510-qzm9wgde	509	23	in	in	IN
cord-336510-qzm9wgde	509	24	another	another	DT
cord-336510-qzm9wgde	509	25	study	study	NN
cord-336510-qzm9wgde	509	26	utilizing	utilize	VBG
cord-336510-qzm9wgde	509	27	IL-12	IL-12	NNP
cord-336510-qzm9wgde	509	28	encoding	encode	VBG
cord-336510-qzm9wgde	509	29	plasmid	plasmid	NN
cord-336510-qzm9wgde	509	30	DNA	dna	NN
cord-336510-qzm9wgde	509	31	,	,	,
cord-336510-qzm9wgde	509	32	corneal	corneal	JJ
cord-336510-qzm9wgde	509	33	expression	expression	NN
cord-336510-qzm9wgde	509	34	of	of	IN
cord-336510-qzm9wgde	509	35	IL-12	IL-12	NNP
cord-336510-qzm9wgde	509	36	reduced	reduce	VBD
cord-336510-qzm9wgde	509	37	the	the	DT
cord-336510-qzm9wgde	509	38	angiogenesis	angiogenesis	NN
cord-336510-qzm9wgde	509	39	,	,	,
cord-336510-qzm9wgde	509	40	and	and	CC
cord-336510-qzm9wgde	509	41	thus	thus	RB
cord-336510-qzm9wgde	509	42	the	the	DT
cord-336510-qzm9wgde	509	43	pathology	pathology	NN
cord-336510-qzm9wgde	509	44	of	of	IN
cord-336510-qzm9wgde	509	45	the	the	DT
cord-336510-qzm9wgde	509	46	infection	infection	NN
cord-336510-qzm9wgde	509	47	[	[	-LRB-
cord-336510-qzm9wgde	509	48	394	394	CD
cord-336510-qzm9wgde	509	49	]	]	-RRB-
cord-336510-qzm9wgde	509	50	.	.	.
cord-336510-qzm9wgde	510	1	However	however	RB
cord-336510-qzm9wgde	510	2	,	,	,
cord-336510-qzm9wgde	510	3	both	both	DT
cord-336510-qzm9wgde	510	4	studies	study	NNS
cord-336510-qzm9wgde	510	5	agreed	agree	VBD
cord-336510-qzm9wgde	510	6	that	that	IN
cord-336510-qzm9wgde	510	7	IL-12	IL-12	NNP
cord-336510-qzm9wgde	510	8	does	do	VBZ
cord-336510-qzm9wgde	510	9	not	not	RB
cord-336510-qzm9wgde	510	10	affect	affect	VB
cord-336510-qzm9wgde	510	11	the	the	DT
cord-336510-qzm9wgde	510	12	local	local	JJ
cord-336510-qzm9wgde	510	13	titres	titre	NNS
cord-336510-qzm9wgde	510	14	of	of	IN
cord-336510-qzm9wgde	510	15	HSV	HSV	NNP
cord-336510-qzm9wgde	510	16	in	in	IN
cord-336510-qzm9wgde	510	17	the	the	DT
cord-336510-qzm9wgde	510	18	eye	eye	NN
cord-336510-qzm9wgde	510	19	.	.	.
cord-336510-qzm9wgde	511	1	After	after	IN
cord-336510-qzm9wgde	511	2	a	a	DT
cord-336510-qzm9wgde	511	3	thermal	thermal	JJ
cord-336510-qzm9wgde	511	4	injury	injury	NN
cord-336510-qzm9wgde	511	5	,	,	,
cord-336510-qzm9wgde	511	6	wide	wide	JJ
cord-336510-qzm9wgde	511	7	-	-	HYPH
cord-336510-qzm9wgde	511	8	spread	spread	VBN
cord-336510-qzm9wgde	511	9	HSV	HSV	NNP
cord-336510-qzm9wgde	511	10	infections	infection	NNS
cord-336510-qzm9wgde	511	11	are	be	VBP
cord-336510-qzm9wgde	511	12	an	an	DT
cord-336510-qzm9wgde	511	13	important	important	JJ
cord-336510-qzm9wgde	511	14	risk	risk	NN
cord-336510-qzm9wgde	511	15	,	,	,
cord-336510-qzm9wgde	511	16	and	and	CC
cord-336510-qzm9wgde	511	17	treatment	treatment	NN
cord-336510-qzm9wgde	511	18	of	of	IN
cord-336510-qzm9wgde	511	19	injured	injure	VBN
cord-336510-qzm9wgde	511	20	mice	mouse	NNS
cord-336510-qzm9wgde	511	21	with	with	IN
cord-336510-qzm9wgde	511	22	IL-12	IL-12	NNP
cord-336510-qzm9wgde	511	23	combined	combine	VBN
cord-336510-qzm9wgde	511	24	with	with	IN
cord-336510-qzm9wgde	511	25	soluble	soluble	JJ
cord-336510-qzm9wgde	511	26	IL-4R	il-4r	CD
cord-336510-qzm9wgde	511	27	results	result	NNS
cord-336510-qzm9wgde	511	28	in	in	IN
cord-336510-qzm9wgde	511	29	augmentation	augmentation	NN
cord-336510-qzm9wgde	511	30	of	of	IN
cord-336510-qzm9wgde	511	31	the	the	DT
cord-336510-qzm9wgde	511	32	IFN	IFN	NNP
cord-336510-qzm9wgde	511	33	-	-	HYPH
cord-336510-qzm9wgde	511	34	γ	γ	NN
cord-336510-qzm9wgde	511	35	production	production	NN
cord-336510-qzm9wgde	511	36	and	and	CC
cord-336510-qzm9wgde	511	37	decreased	decrease	VBD
cord-336510-qzm9wgde	511	38	viral	viral	JJ
cord-336510-qzm9wgde	511	39	replication	replication	NN
cord-336510-qzm9wgde	511	40	and	and	CC
cord-336510-qzm9wgde	511	41	mortality	mortality	NN
cord-336510-qzm9wgde	511	42	[	[	-LRB-
cord-336510-qzm9wgde	511	43	395	395	CD
cord-336510-qzm9wgde	511	44	]	]	-RRB-
cord-336510-qzm9wgde	511	45	.	.	.
cord-336510-qzm9wgde	512	1	In	in	IN
cord-336510-qzm9wgde	512	2	mice	mouse	NNS
cord-336510-qzm9wgde	512	3	infected	infect	VBN
cord-336510-qzm9wgde	512	4	with	with	IN
cord-336510-qzm9wgde	512	5	murine	murine	JJ
cord-336510-qzm9wgde	512	6	cytomegalovirus	cytomegalovirus	NN
cord-336510-qzm9wgde	512	7	(	(	-LRB-
cord-336510-qzm9wgde	512	8	MCMV	MCMV	NNP
cord-336510-qzm9wgde	512	9	)	)	-RRB-
cord-336510-qzm9wgde	512	10	production	production	NN
cord-336510-qzm9wgde	512	11	of	of	IN
cord-336510-qzm9wgde	512	12	IL-12-induced	IL-12-induced	NNP
cord-336510-qzm9wgde	512	13	IFN	IFN	NNP
cord-336510-qzm9wgde	512	14	-	-	HYPH
cord-336510-qzm9wgde	512	15	γ	γ	NNP
cord-336510-qzm9wgde	512	16	by	by	IN
cord-336510-qzm9wgde	512	17	NK	NK	NNP
cord-336510-qzm9wgde	512	18	cells	cell	NNS
cord-336510-qzm9wgde	512	19	has	have	VBZ
cord-336510-qzm9wgde	512	20	been	be	VBN
cord-336510-qzm9wgde	512	21	demonstrated	demonstrate	VBN
cord-336510-qzm9wgde	512	22	in	in	IN
cord-336510-qzm9wgde	512	23	vivo	vivo	NN
cord-336510-qzm9wgde	512	24	,	,	,
cord-336510-qzm9wgde	512	25	and	and	CC
cord-336510-qzm9wgde	512	26	the	the	DT
cord-336510-qzm9wgde	512	27	system	system	NN
cord-336510-qzm9wgde	512	28	was	be	VBD
cord-336510-qzm9wgde	512	29	further	further	RB
cord-336510-qzm9wgde	512	30	shown	show	VBN
cord-336510-qzm9wgde	512	31	to	to	TO
cord-336510-qzm9wgde	512	32	lower	lower	VB
cord-336510-qzm9wgde	512	33	the	the	DT
cord-336510-qzm9wgde	512	34	viral	viral	JJ
cord-336510-qzm9wgde	512	35	titres	titre	NNS
cord-336510-qzm9wgde	512	36	[	[	-LRB-
cord-336510-qzm9wgde	512	37	396	396	CD
cord-336510-qzm9wgde	512	38	,	,	,
cord-336510-qzm9wgde	512	39	397	397	CD
cord-336510-qzm9wgde	512	40	]	]	-RRB-
cord-336510-qzm9wgde	512	41	.	.	.
cord-336510-qzm9wgde	513	1	The	the	DT
cord-336510-qzm9wgde	513	2	IL-12	IL-12	NNP
cord-336510-qzm9wgde	513	3	/	/	SYM
cord-336510-qzm9wgde	513	4	IFN	IFN	NNP
cord-336510-qzm9wgde	513	5	-	-	HYPH
cord-336510-qzm9wgde	513	6	γ	γ	NN
cord-336510-qzm9wgde	513	7	system	system	NN
cord-336510-qzm9wgde	513	8	seems	seem	VBZ
cord-336510-qzm9wgde	513	9	,	,	,
cord-336510-qzm9wgde	513	10	however	however	RB
cord-336510-qzm9wgde	513	11	,	,	,
cord-336510-qzm9wgde	513	12	not	not	RB
cord-336510-qzm9wgde	513	13	to	to	TO
cord-336510-qzm9wgde	513	14	be	be	VB
cord-336510-qzm9wgde	513	15	of	of	IN
cord-336510-qzm9wgde	513	16	importance	importance	NN
cord-336510-qzm9wgde	513	17	in	in	IN
cord-336510-qzm9wgde	513	18	all	all	DT
cord-336510-qzm9wgde	513	19	viral	viral	JJ
cord-336510-qzm9wgde	513	20	infections	infection	NNS
cord-336510-qzm9wgde	513	21	,	,	,
cord-336510-qzm9wgde	513	22	in	in	IN
cord-336510-qzm9wgde	513	23	that	that	IN
cord-336510-qzm9wgde	513	24	the	the	DT
cord-336510-qzm9wgde	513	25	latter	latter	JJ
cord-336510-qzm9wgde	513	26	study	study	NN
cord-336510-qzm9wgde	513	27	could	could	MD
cord-336510-qzm9wgde	513	28	not	not	RB
cord-336510-qzm9wgde	513	29	detect	detect	VB
cord-336510-qzm9wgde	513	30	any	any	DT
cord-336510-qzm9wgde	513	31	production	production	NN
cord-336510-qzm9wgde	513	32	of	of	IN
cord-336510-qzm9wgde	513	33	early	early	JJ
cord-336510-qzm9wgde	513	34	IL-12	IL-12	NNP
cord-336510-qzm9wgde	513	35	or	or	CC
cord-336510-qzm9wgde	513	36	IFN	IFN	NNP
cord-336510-qzm9wgde	513	37	-	-	HYPH
cord-336510-qzm9wgde	513	38	γ	γ	NNP
cord-336510-qzm9wgde	513	39	in	in	IN
cord-336510-qzm9wgde	513	40	a	a	DT
cord-336510-qzm9wgde	513	41	model	model	NN
cord-336510-qzm9wgde	513	42	of	of	IN
cord-336510-qzm9wgde	513	43	infection	infection	NN
cord-336510-qzm9wgde	513	44	with	with	IN
cord-336510-qzm9wgde	513	45	the	the	DT
cord-336510-qzm9wgde	513	46	arenavirus	arenavirus	NNP
cord-336510-qzm9wgde	513	47	lymphocytic	lymphocytic	JJ
cord-336510-qzm9wgde	513	48	choriomeningitis	choriomeningitis	NNP
cord-336510-qzm9wgde	513	49	virus	virus	NN
cord-336510-qzm9wgde	513	50	.	.	.
cord-336510-qzm9wgde	514	1	Analyses	analysis	NNS
cord-336510-qzm9wgde	514	2	of	of	IN
cord-336510-qzm9wgde	514	3	the	the	DT
cord-336510-qzm9wgde	514	4	IL-12	IL-12	NNP
cord-336510-qzm9wgde	514	5	,	,	,
cord-336510-qzm9wgde	514	6	-23	-23	NN
cord-336510-qzm9wgde	514	7	/	/	SYM
cord-336510-qzm9wgde	514	8	IFN	IFN	NNP
cord-336510-qzm9wgde	514	9	-	-	HYPH
cord-336510-qzm9wgde	514	10	γ	γ	NNP
cord-336510-qzm9wgde	514	11	system	system	NN
cord-336510-qzm9wgde	514	12	in	in	IN
cord-336510-qzm9wgde	514	13	humans	human	NNS
cord-336510-qzm9wgde	514	14	with	with	IN
cord-336510-qzm9wgde	514	15	genetic	genetic	JJ
cord-336510-qzm9wgde	514	16	defects	defect	NNS
cord-336510-qzm9wgde	514	17	and	and	CC
cord-336510-qzm9wgde	514	18	in	in	IN
cord-336510-qzm9wgde	514	19	KO	KO	NNP
cord-336510-qzm9wgde	514	20	-	-	HYPH
cord-336510-qzm9wgde	514	21	mice	mouse	NNS
cord-336510-qzm9wgde	514	22	reveal	reveal	VBP
cord-336510-qzm9wgde	514	23	more	more	JJR
cord-336510-qzm9wgde	514	24	redundancy	redundancy	NN
cord-336510-qzm9wgde	514	25	in	in	IN
cord-336510-qzm9wgde	514	26	man	man	NN
cord-336510-qzm9wgde	514	27	than	than	IN
cord-336510-qzm9wgde	514	28	in	in	IN
cord-336510-qzm9wgde	514	29	mouse	mouse	NN
cord-336510-qzm9wgde	514	30	and	and	CC
cord-336510-qzm9wgde	514	31	indicate	indicate	VBP
cord-336510-qzm9wgde	514	32	that	that	IN
cord-336510-qzm9wgde	514	33	the	the	DT
cord-336510-qzm9wgde	514	34	system	system	NN
cord-336510-qzm9wgde	514	35	is	be	VBZ
cord-336510-qzm9wgde	514	36	of	of	IN
cord-336510-qzm9wgde	514	37	more	more	JJR
cord-336510-qzm9wgde	514	38	importance	importance	NN
cord-336510-qzm9wgde	514	39	in	in	IN
cord-336510-qzm9wgde	514	40	DNA	dna	NN
cord-336510-qzm9wgde	514	41	-	-	:
cord-336510-qzm9wgde	514	42	than	than	IN
cord-336510-qzm9wgde	514	43	in	in	IN
cord-336510-qzm9wgde	514	44	RNA	RNA	NNP
cord-336510-qzm9wgde	514	45	-	-	HYPH
cord-336510-qzm9wgde	514	46	virus	virus	NN
cord-336510-qzm9wgde	514	47	infections	infection	NNS
cord-336510-qzm9wgde	514	48	[	[	-LRB-
cord-336510-qzm9wgde	514	49	219	219	CD
cord-336510-qzm9wgde	514	50	]	]	-RRB-
cord-336510-qzm9wgde	514	51	.	.	.
cord-336510-qzm9wgde	515	1	The	the	DT
cord-336510-qzm9wgde	515	2	producers	producer	NNS
cord-336510-qzm9wgde	515	3	of	of	IN
cord-336510-qzm9wgde	515	4	early	early	JJ
cord-336510-qzm9wgde	515	5	IFN	IFN	NNP
cord-336510-qzm9wgde	515	6	-	-	HYPH
cord-336510-qzm9wgde	515	7	γ	γ	NNP
cord-336510-qzm9wgde	515	8	,	,	,
cord-336510-qzm9wgde	515	9	the	the	DT
cord-336510-qzm9wgde	515	10	NK	NK	NNP
cord-336510-qzm9wgde	515	11	and	and	CC
cord-336510-qzm9wgde	515	12	NKT	NKT	NNP
cord-336510-qzm9wgde	515	13	cells	cell	NNS
cord-336510-qzm9wgde	515	14	,	,	,
cord-336510-qzm9wgde	515	15	and	and	CC
cord-336510-qzm9wgde	515	16	the	the	DT
cord-336510-qzm9wgde	515	17	cytokine	cytokine	NN
cord-336510-qzm9wgde	515	18	IL-15	IL-15	NNP
cord-336510-qzm9wgde	515	19	and	and	CC
cord-336510-qzm9wgde	515	20	the	the	DT
cord-336510-qzm9wgde	515	21	transcription	transcription	NN
cord-336510-qzm9wgde	515	22	factor	factor	NN
cord-336510-qzm9wgde	515	23	T	t	NN
cord-336510-qzm9wgde	515	24	-	-	HYPH
cord-336510-qzm9wgde	515	25	bet	bet	NN
cord-336510-qzm9wgde	515	26	,	,	,
cord-336510-qzm9wgde	515	27	which	which	WDT
cord-336510-qzm9wgde	515	28	are	be	VBP
cord-336510-qzm9wgde	515	29	both	both	DT
cord-336510-qzm9wgde	515	30	crucial	crucial	JJ
cord-336510-qzm9wgde	515	31	for	for	IN
cord-336510-qzm9wgde	515	32	the	the	DT
cord-336510-qzm9wgde	515	33	differentiation	differentiation	NN
cord-336510-qzm9wgde	515	34	and	and	CC
cord-336510-qzm9wgde	515	35	function	function	NN
cord-336510-qzm9wgde	515	36	of	of	IN
cord-336510-qzm9wgde	515	37	these	these	DT
cord-336510-qzm9wgde	515	38	cells	cell	NNS
cord-336510-qzm9wgde	515	39	,	,	,
cord-336510-qzm9wgde	515	40	have	have	VBP
cord-336510-qzm9wgde	515	41	all	all	DT
cord-336510-qzm9wgde	515	42	been	be	VBN
cord-336510-qzm9wgde	515	43	shown	show	VBN
cord-336510-qzm9wgde	515	44	to	to	TO
cord-336510-qzm9wgde	515	45	be	be	VB
cord-336510-qzm9wgde	515	46	decisive	decisive	JJ
cord-336510-qzm9wgde	515	47	for	for	IN
cord-336510-qzm9wgde	515	48	the	the	DT
cord-336510-qzm9wgde	515	49	early	early	JJ
cord-336510-qzm9wgde	515	50	control	control	NN
cord-336510-qzm9wgde	515	51	of	of	IN
cord-336510-qzm9wgde	515	52	HSV	HSV	NNP
cord-336510-qzm9wgde	515	53	infection	infection	NN
cord-336510-qzm9wgde	515	54	in	in	IN
cord-336510-qzm9wgde	515	55	vivo	vivo	NN
cord-336510-qzm9wgde	515	56	[	[	-LRB-
cord-336510-qzm9wgde	515	57	268	268	CD
cord-336510-qzm9wgde	515	58	,	,	,
cord-336510-qzm9wgde	515	59	[	[	-LRB-
cord-336510-qzm9wgde	515	60	398	398	CD
cord-336510-qzm9wgde	515	61	]	]	-RRB-
cord-336510-qzm9wgde	515	62	[	[	-LRB-
cord-336510-qzm9wgde	515	63	399	399	CD
cord-336510-qzm9wgde	515	64	]	]	-RRB-
cord-336510-qzm9wgde	515	65	[	[	-LRB-
cord-336510-qzm9wgde	515	66	400	400	CD
cord-336510-qzm9wgde	515	67	]	]	-RRB-
cord-336510-qzm9wgde	515	68	.	.	.
cord-336510-qzm9wgde	516	1	Although	although	IN
cord-336510-qzm9wgde	516	2	NK	NK	NNP
cord-336510-qzm9wgde	516	3	cells	cell	NNS
cord-336510-qzm9wgde	516	4	but	but	CC
cord-336510-qzm9wgde	516	5	not	not	RB
cord-336510-qzm9wgde	516	6	IFN	IFN	NNP
cord-336510-qzm9wgde	516	7	-	-	HYPH
cord-336510-qzm9wgde	516	8	γ	γ	NNP
cord-336510-qzm9wgde	516	9	was	be	VBD
cord-336510-qzm9wgde	516	10	shown	show	VBN
cord-336510-qzm9wgde	516	11	to	to	TO
cord-336510-qzm9wgde	516	12	be	be	VB
cord-336510-qzm9wgde	516	13	decisive	decisive	JJ
cord-336510-qzm9wgde	516	14	for	for	IN
cord-336510-qzm9wgde	516	15	survival	survival	NN
cord-336510-qzm9wgde	516	16	from	from	IN
cord-336510-qzm9wgde	516	17	ocular	ocular	JJ
cord-336510-qzm9wgde	516	18	infections	infection	NNS
cord-336510-qzm9wgde	516	19	[	[	-LRB-
cord-336510-qzm9wgde	516	20	401	401	CD
cord-336510-qzm9wgde	516	21	]	]	-RRB-
cord-336510-qzm9wgde	516	22	,	,	,
cord-336510-qzm9wgde	516	23	such	such	PDT
cord-336510-qzm9wgde	516	24	an	an	DT
cord-336510-qzm9wgde	516	25	effect	effect	NN
cord-336510-qzm9wgde	516	26	of	of	IN
cord-336510-qzm9wgde	516	27	IFN	IFN	NNP
cord-336510-qzm9wgde	516	28	-	-	HYPH
cord-336510-qzm9wgde	516	29	γ	γ	NNP
cord-336510-qzm9wgde	516	30	has	have	VBZ
cord-336510-qzm9wgde	516	31	been	be	VBN
cord-336510-qzm9wgde	516	32	seen	see	VBN
cord-336510-qzm9wgde	516	33	by	by	IN
cord-336510-qzm9wgde	516	34	others	other	NNS
cord-336510-qzm9wgde	516	35	[	[	-LRB-
cord-336510-qzm9wgde	516	36	402	402	CD
cord-336510-qzm9wgde	516	37	]	]	-RRB-
cord-336510-qzm9wgde	516	38	.	.	.
cord-336510-qzm9wgde	517	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	517	2	,	,	,
cord-336510-qzm9wgde	517	3	a	a	DT
cord-336510-qzm9wgde	517	4	review	review	NN
cord-336510-qzm9wgde	517	5	of	of	IN
cord-336510-qzm9wgde	517	6	genetic	genetic	JJ
cord-336510-qzm9wgde	517	7	functional	functional	JJ
cord-336510-qzm9wgde	517	8	NK	NK	NNP
cord-336510-qzm9wgde	517	9	cell	cell	NN
cord-336510-qzm9wgde	517	10	defects	defect	NNS
cord-336510-qzm9wgde	517	11	found	find	VBD
cord-336510-qzm9wgde	517	12	NK	NK	NNP
cord-336510-qzm9wgde	517	13	cells	cell	NNS
cord-336510-qzm9wgde	517	14	and	and	CC
cord-336510-qzm9wgde	517	15	their	-PRON-	PRP$
cord-336510-qzm9wgde	517	16	innate	innate	JJ
cord-336510-qzm9wgde	517	17	IFN	IFN	NNP
cord-336510-qzm9wgde	517	18	-	-	HYPH
cord-336510-qzm9wgde	517	19	γ	γ	NN
cord-336510-qzm9wgde	517	20	production	production	NN
cord-336510-qzm9wgde	517	21	to	to	TO
cord-336510-qzm9wgde	517	22	be	be	VB
cord-336510-qzm9wgde	517	23	of	of	IN
cord-336510-qzm9wgde	517	24	central	central	JJ
cord-336510-qzm9wgde	517	25	importance	importance	NN
cord-336510-qzm9wgde	517	26	in	in	IN
cord-336510-qzm9wgde	517	27	herpesvirus	herpesvirus	NN
cord-336510-qzm9wgde	517	28	infections	infection	NNS
cord-336510-qzm9wgde	517	29	[	[	-LRB-
cord-336510-qzm9wgde	517	30	403	403	CD
cord-336510-qzm9wgde	517	31	]	]	-RRB-
cord-336510-qzm9wgde	517	32	.	.	.
cord-336510-qzm9wgde	518	1	Overall	overall	RB
cord-336510-qzm9wgde	518	2	,	,	,
cord-336510-qzm9wgde	518	3	it	-PRON-	PRP
cord-336510-qzm9wgde	518	4	can	can	MD
cord-336510-qzm9wgde	518	5	be	be	VB
cord-336510-qzm9wgde	518	6	concluded	conclude	VBN
cord-336510-qzm9wgde	518	7	that	that	IN
cord-336510-qzm9wgde	518	8	the	the	DT
cord-336510-qzm9wgde	518	9	IL-12	IL-12	NNP
cord-336510-qzm9wgde	518	10	/	/	SYM
cord-336510-qzm9wgde	518	11	IFN	IFN	NNP
cord-336510-qzm9wgde	518	12	-	-	HYPH
cord-336510-qzm9wgde	518	13	γ	γ	NNP
cord-336510-qzm9wgde	518	14	system	system	NN
cord-336510-qzm9wgde	518	15	is	be	VBZ
cord-336510-qzm9wgde	518	16	active	active	JJ
cord-336510-qzm9wgde	518	17	in	in	IN
cord-336510-qzm9wgde	518	18	HSV	HSV	NNP
cord-336510-qzm9wgde	518	19	infections	infection	NNS
cord-336510-qzm9wgde	518	20	and	and	CC
cord-336510-qzm9wgde	518	21	possesses	possess	VBZ
cord-336510-qzm9wgde	518	22	an	an	DT
cord-336510-qzm9wgde	518	23	important	important	JJ
cord-336510-qzm9wgde	518	24	antiviral	antiviral	JJ
cord-336510-qzm9wgde	518	25	potential	potential	NN
cord-336510-qzm9wgde	518	26	,	,	,
cord-336510-qzm9wgde	518	27	capable	capable	JJ
cord-336510-qzm9wgde	518	28	of	of	IN
cord-336510-qzm9wgde	518	29	controlling	control	VBG
cord-336510-qzm9wgde	518	30	viral	viral	JJ
cord-336510-qzm9wgde	518	31	replication	replication	NN
cord-336510-qzm9wgde	518	32	during	during	IN
cord-336510-qzm9wgde	518	33	the	the	DT
cord-336510-qzm9wgde	518	34	early	early	JJ
cord-336510-qzm9wgde	518	35	phases	phase	NNS
cord-336510-qzm9wgde	518	36	of	of	IN
cord-336510-qzm9wgde	518	37	infection	infection	NN
cord-336510-qzm9wgde	518	38	.	.	.
cord-336510-qzm9wgde	519	1	In	in	IN
cord-336510-qzm9wgde	519	2	macrophages	macrophage	NNS
cord-336510-qzm9wgde	519	3	exposed	expose	VBN
cord-336510-qzm9wgde	519	4	to	to	IN
cord-336510-qzm9wgde	519	5	IFN	IFN	NNP
cord-336510-qzm9wgde	519	6	-	-	HYPH
cord-336510-qzm9wgde	519	7	γ	γ	NNP
cord-336510-qzm9wgde	519	8	,	,	,
cord-336510-qzm9wgde	519	9	the	the	DT
cord-336510-qzm9wgde	519	10	enzyme	enzyme	NN
cord-336510-qzm9wgde	519	11	inducible	inducible	JJ
cord-336510-qzm9wgde	519	12	nitric	nitric	NN
cord-336510-qzm9wgde	519	13	oxide	oxide	NN
cord-336510-qzm9wgde	519	14	synthase	synthase	NN
cord-336510-qzm9wgde	519	15	is	be	VBZ
cord-336510-qzm9wgde	519	16	induced	induce	VBN
cord-336510-qzm9wgde	519	17	,	,	,
cord-336510-qzm9wgde	519	18	which	which	WDT
cord-336510-qzm9wgde	519	19	eventually	eventually	RB
cord-336510-qzm9wgde	519	20	results	result	VBZ
cord-336510-qzm9wgde	519	21	in	in	IN
cord-336510-qzm9wgde	519	22	production	production	NN
cord-336510-qzm9wgde	519	23	of	of	IN
cord-336510-qzm9wgde	519	24	NO	no	DT
cord-336510-qzm9wgde	519	25	from	from	IN
cord-336510-qzm9wgde	519	26	molecular	molecular	JJ
cord-336510-qzm9wgde	519	27	oxygen	oxygen	NN
cord-336510-qzm9wgde	519	28	and	and	CC
cord-336510-qzm9wgde	519	29	a	a	DT
cord-336510-qzm9wgde	519	30	guanidino	guanidino	JJ
cord-336510-qzm9wgde	519	31	nitrogen	nitrogen	NN
cord-336510-qzm9wgde	519	32	by	by	IN
cord-336510-qzm9wgde	519	33	conversion	conversion	NN
cord-336510-qzm9wgde	519	34	of	of	IN
cord-336510-qzm9wgde	519	35	L	l	NN
cord-336510-qzm9wgde	519	36	-	-	HYPH
cord-336510-qzm9wgde	519	37	arginine	arginine	NN
cord-336510-qzm9wgde	519	38	to	to	IN
cord-336510-qzm9wgde	519	39	L	l	NN
cord-336510-qzm9wgde	519	40	-	-	HYPH
cord-336510-qzm9wgde	519	41	citrulline	citrulline	NN
cord-336510-qzm9wgde	519	42	[	[	-LRB-
cord-336510-qzm9wgde	519	43	404	404	CD
cord-336510-qzm9wgde	519	44	]	]	-RRB-
cord-336510-qzm9wgde	519	45	.	.	.
cord-336510-qzm9wgde	520	1	Upon	upon	IN
cord-336510-qzm9wgde	520	2	HSV	HSV	NNP
cord-336510-qzm9wgde	520	3	infection	infection	NN
cord-336510-qzm9wgde	520	4	,	,	,
cord-336510-qzm9wgde	520	5	the	the	DT
cord-336510-qzm9wgde	520	6	iNOS	inos	JJ
cord-336510-qzm9wgde	520	7	gene	gene	NN
cord-336510-qzm9wgde	520	8	is	be	VBZ
cord-336510-qzm9wgde	520	9	induced	induce	VBN
cord-336510-qzm9wgde	520	10	,	,	,
cord-336510-qzm9wgde	520	11	as	as	IN
cord-336510-qzm9wgde	520	12	shown	show	VBN
cord-336510-qzm9wgde	520	13	by	by	IN
cord-336510-qzm9wgde	520	14	detection	detection	NN
cord-336510-qzm9wgde	520	15	of	of	IN
cord-336510-qzm9wgde	520	16	iNOS	iNOS	NNP
cord-336510-qzm9wgde	520	17	-	-	HYPH
cord-336510-qzm9wgde	520	18	mRNA	mrna	NN
cord-336510-qzm9wgde	520	19	in	in	IN
cord-336510-qzm9wgde	520	20	infected	infected	JJ
cord-336510-qzm9wgde	520	21	mouse	mouse	NN
cord-336510-qzm9wgde	520	22	peritoneal	peritoneal	NN
cord-336510-qzm9wgde	520	23	cells	cell	NNS
cord-336510-qzm9wgde	520	24	and	and	CC
cord-336510-qzm9wgde	520	25	corneal	corneal	JJ
cord-336510-qzm9wgde	520	26	neutrophils	neutrophil	NNS
cord-336510-qzm9wgde	520	27	[	[	-LRB-
cord-336510-qzm9wgde	520	28	405	405	CD
cord-336510-qzm9wgde	520	29	,	,	,
cord-336510-qzm9wgde	520	30	406	406	CD
cord-336510-qzm9wgde	520	31	]	]	-RRB-
cord-336510-qzm9wgde	520	32	.	.	.
cord-336510-qzm9wgde	521	1	The	the	DT
cord-336510-qzm9wgde	521	2	production	production	NN
cord-336510-qzm9wgde	521	3	of	of	IN
cord-336510-qzm9wgde	521	4	NO	no	DT
cord-336510-qzm9wgde	521	5	in	in	IN
cord-336510-qzm9wgde	521	6	HSV	HSV	NNP
cord-336510-qzm9wgde	521	7	-	-	HYPH
cord-336510-qzm9wgde	521	8	infected	infect	VBN
cord-336510-qzm9wgde	521	9	cultures	culture	NNS
cord-336510-qzm9wgde	521	10	of	of	IN
cord-336510-qzm9wgde	521	11	resting	rest	VBG
cord-336510-qzm9wgde	521	12	mouse	mouse	NN
cord-336510-qzm9wgde	521	13	peritoneal	peritoneal	NN
cord-336510-qzm9wgde	521	14	cells	cell	NNS
cord-336510-qzm9wgde	521	15	,	,	,
cord-336510-qzm9wgde	521	16	which	which	WDT
cord-336510-qzm9wgde	521	17	comprise	comprise	VBP
cord-336510-qzm9wgde	521	18	a	a	DT
cord-336510-qzm9wgde	521	19	mixed	mixed	JJ
cord-336510-qzm9wgde	521	20	population	population	NN
cord-336510-qzm9wgde	521	21	of	of	IN
cord-336510-qzm9wgde	521	22	macrophages	macrophage	NNS
cord-336510-qzm9wgde	521	23	,	,	,
cord-336510-qzm9wgde	521	24	lymphocytes	lymphocyte	NNS
cord-336510-qzm9wgde	521	25	,	,	,
cord-336510-qzm9wgde	521	26	NK	NK	NNP
cord-336510-qzm9wgde	521	27	cells	cell	NNS
cord-336510-qzm9wgde	522	1	etc	etc	FW
cord-336510-qzm9wgde	522	2	.	.	.
cord-336510-qzm9wgde	523	1	,	,	,
cord-336510-qzm9wgde	523	2	is	be	VBZ
cord-336510-qzm9wgde	523	3	dependent	dependent	JJ
cord-336510-qzm9wgde	523	4	on	on	IN
cord-336510-qzm9wgde	523	5	the	the	DT
cord-336510-qzm9wgde	523	6	virus	virus	NN
cord-336510-qzm9wgde	523	7	being	be	VBG
cord-336510-qzm9wgde	523	8	infectious	infectious	JJ
cord-336510-qzm9wgde	523	9	[	[	-LRB-
cord-336510-qzm9wgde	523	10	405	405	CD
cord-336510-qzm9wgde	523	11	]	]	-RRB-
cord-336510-qzm9wgde	523	12	.	.	.
cord-336510-qzm9wgde	524	1	This	this	DT
cord-336510-qzm9wgde	524	2	is	be	VBZ
cord-336510-qzm9wgde	524	3	in	in	IN
cord-336510-qzm9wgde	524	4	line	line	NN
cord-336510-qzm9wgde	524	5	with	with	IN
cord-336510-qzm9wgde	524	6	the	the	DT
cord-336510-qzm9wgde	524	7	requirement	requirement	NN
cord-336510-qzm9wgde	524	8	of	of	IN
cord-336510-qzm9wgde	524	9	infectious	infectious	JJ
cord-336510-qzm9wgde	524	10	HSV	hsv	NN
cord-336510-qzm9wgde	524	11	for	for	IN
cord-336510-qzm9wgde	524	12	IL-12	IL-12	NNP
cord-336510-qzm9wgde	524	13	production	production	NN
cord-336510-qzm9wgde	524	14	and	and	CC
cord-336510-qzm9wgde	524	15	thus	thus	RB
cord-336510-qzm9wgde	524	16	for	for	IN
cord-336510-qzm9wgde	524	17	production	production	NN
cord-336510-qzm9wgde	524	18	of	of	IN
cord-336510-qzm9wgde	524	19	IFN	IFN	NNP
cord-336510-qzm9wgde	524	20	-	-	HYPH
cord-336510-qzm9wgde	524	21	γ	γ	NNP
cord-336510-qzm9wgde	524	22	as	as	IN
cord-336510-qzm9wgde	524	23	described	describe	VBN
cord-336510-qzm9wgde	524	24	previously	previously	RB
cord-336510-qzm9wgde	524	25	[	[	-LRB-
cord-336510-qzm9wgde	524	26	238	238	CD
cord-336510-qzm9wgde	524	27	]	]	-RRB-
cord-336510-qzm9wgde	524	28	.	.	.
cord-336510-qzm9wgde	525	1	NO	no	DT
cord-336510-qzm9wgde	525	2	could	could	MD
cord-336510-qzm9wgde	525	3	itself	-PRON-	PRP
cord-336510-qzm9wgde	525	4	be	be	VB
cord-336510-qzm9wgde	525	5	involved	involve	VBN
cord-336510-qzm9wgde	525	6	in	in	IN
cord-336510-qzm9wgde	525	7	a	a	DT
cord-336510-qzm9wgde	525	8	positive	positive	JJ
cord-336510-qzm9wgde	525	9	feed	feed	NN
cord-336510-qzm9wgde	525	10	-	-	HYPH
cord-336510-qzm9wgde	525	11	back	back	NN
cord-336510-qzm9wgde	525	12	,	,	,
cord-336510-qzm9wgde	525	13	in	in	IN
cord-336510-qzm9wgde	525	14	that	that	DT
cord-336510-qzm9wgde	525	15	signalling	signalling	NN
cord-336510-qzm9wgde	525	16	of	of	IN
cord-336510-qzm9wgde	525	17	IL-12	IL-12	NNP
cord-336510-qzm9wgde	525	18	utilizing	utilize	VBG
cord-336510-qzm9wgde	525	19	Tyk2	Tyk2	NNP
cord-336510-qzm9wgde	525	20	requires	require	VBZ
cord-336510-qzm9wgde	525	21	the	the	DT
cord-336510-qzm9wgde	525	22	activity	activity	NN
cord-336510-qzm9wgde	525	23	of	of	IN
cord-336510-qzm9wgde	525	24	NO	no	DT
cord-336510-qzm9wgde	525	25	[	[	-LRB-
cord-336510-qzm9wgde	525	26	407	407	CD
cord-336510-qzm9wgde	525	27	]	]	-RRB-
cord-336510-qzm9wgde	525	28	.	.	.
cord-336510-qzm9wgde	526	1	When	when	WRB
cord-336510-qzm9wgde	526	2	exogenous	exogenous	JJ
cord-336510-qzm9wgde	526	3	IFN	IFN	NNP
cord-336510-qzm9wgde	526	4	-	-	HYPH
cord-336510-qzm9wgde	526	5	γ	γ	NNP
cord-336510-qzm9wgde	526	6	is	be	VBZ
cord-336510-qzm9wgde	526	7	added	add	VBN
cord-336510-qzm9wgde	526	8	to	to	IN
cord-336510-qzm9wgde	526	9	virus	virus	NN
cord-336510-qzm9wgde	526	10	-	-	HYPH
cord-336510-qzm9wgde	526	11	infected	infect	VBN
cord-336510-qzm9wgde	526	12	cells	cell	NNS
cord-336510-qzm9wgde	526	13	,	,	,
cord-336510-qzm9wgde	526	14	a	a	DT
cord-336510-qzm9wgde	526	15	marked	marked	JJ
cord-336510-qzm9wgde	526	16	synergism	synergism	NN
cord-336510-qzm9wgde	526	17	is	be	VBZ
cord-336510-qzm9wgde	526	18	seen	see	VBN
cord-336510-qzm9wgde	526	19	.	.	.
cord-336510-qzm9wgde	527	1	This	this	DT
cord-336510-qzm9wgde	527	2	synergistic	synergistic	JJ
cord-336510-qzm9wgde	527	3	effect	effect	NN
cord-336510-qzm9wgde	527	4	of	of	IN
cord-336510-qzm9wgde	527	5	HSV	HSV	NNP
cord-336510-qzm9wgde	527	6	on	on	IN
cord-336510-qzm9wgde	527	7	the	the	DT
cord-336510-qzm9wgde	527	8	IFN	IFN	NNP
cord-336510-qzm9wgde	527	9	-	-	HYPH
cord-336510-qzm9wgde	527	10	γ	γ	NN
cord-336510-qzm9wgde	527	11	-	-	HYPH
cord-336510-qzm9wgde	527	12	induced	induce	VBN
cord-336510-qzm9wgde	527	13	NO	no	DT
cord-336510-qzm9wgde	527	14	production	production	NN
cord-336510-qzm9wgde	527	15	in	in	IN
cord-336510-qzm9wgde	527	16	macrophages	macrophage	NNS
cord-336510-qzm9wgde	527	17	was	be	VBD
cord-336510-qzm9wgde	527	18	shown	show	VBN
cord-336510-qzm9wgde	527	19	to	to	TO
cord-336510-qzm9wgde	527	20	be	be	VB
cord-336510-qzm9wgde	527	21	mediated	mediate	VBN
cord-336510-qzm9wgde	527	22	by	by	IN
cord-336510-qzm9wgde	527	23	autocrine	autocrine	JJ
cord-336510-qzm9wgde	527	24	secretion	secretion	NN
cord-336510-qzm9wgde	527	25	of	of	IN
cord-336510-qzm9wgde	527	26	TNF	TNF	NNP
cord-336510-qzm9wgde	527	27	[	[	-LRB-
cord-336510-qzm9wgde	527	28	325	325	CD
cord-336510-qzm9wgde	527	29	,	,	,
cord-336510-qzm9wgde	527	30	405	405	CD
cord-336510-qzm9wgde	527	31	]	]	-RRB-
cord-336510-qzm9wgde	527	32	.	.	.
cord-336510-qzm9wgde	528	1	In	in	IN
cord-336510-qzm9wgde	528	2	line	line	NN
cord-336510-qzm9wgde	528	3	with	with	IN
cord-336510-qzm9wgde	528	4	this	this	DT
cord-336510-qzm9wgde	528	5	,	,	,
cord-336510-qzm9wgde	528	6	mice	mouse	NNS
cord-336510-qzm9wgde	528	7	with	with	IN
cord-336510-qzm9wgde	528	8	a	a	DT
cord-336510-qzm9wgde	528	9	targeted	target	VBN
cord-336510-qzm9wgde	528	10	disruption	disruption	NN
cord-336510-qzm9wgde	528	11	of	of	IN
cord-336510-qzm9wgde	528	12	the	the	DT
cord-336510-qzm9wgde	528	13	TNF	TNF	NNP
cord-336510-qzm9wgde	528	14	gene	gene	NN
cord-336510-qzm9wgde	528	15	showed	show	VBD
cord-336510-qzm9wgde	528	16	impaired	impaired	JJ
cord-336510-qzm9wgde	528	17	resistance	resistance	NN
cord-336510-qzm9wgde	528	18	to	to	IN
cord-336510-qzm9wgde	528	19	HSV	HSV	NNP
cord-336510-qzm9wgde	528	20	and	and	CC
cord-336510-qzm9wgde	528	21	increased	increase	VBN
cord-336510-qzm9wgde	528	22	viral	viral	JJ
cord-336510-qzm9wgde	528	23	replication	replication	NN
cord-336510-qzm9wgde	528	24	within	within	IN
cord-336510-qzm9wgde	528	25	the	the	DT
cord-336510-qzm9wgde	528	26	first	first	JJ
cord-336510-qzm9wgde	528	27	days	day	NNS
cord-336510-qzm9wgde	528	28	of	of	IN
cord-336510-qzm9wgde	528	29	infection	infection	NN
cord-336510-qzm9wgde	528	30	[	[	-LRB-
cord-336510-qzm9wgde	528	31	408	408	CD
cord-336510-qzm9wgde	528	32	]	]	-RRB-
cord-336510-qzm9wgde	528	33	,	,	,
cord-336510-qzm9wgde	528	34	and	and	CC
cord-336510-qzm9wgde	528	35	antibodies	antibody	NNS
cord-336510-qzm9wgde	528	36	to	to	IN
cord-336510-qzm9wgde	528	37	TNF	TNF	NNP
cord-336510-qzm9wgde	528	38	and	and	CC
cord-336510-qzm9wgde	528	39	an	an	DT
cord-336510-qzm9wgde	528	40	inhibitor	inhibitor	NN
cord-336510-qzm9wgde	528	41	of	of	IN
cord-336510-qzm9wgde	528	42	NO	no	DT
cord-336510-qzm9wgde	528	43	production	production	NN
cord-336510-qzm9wgde	528	44	impaired	impair	VBD
cord-336510-qzm9wgde	528	45	early	early	JJ
cord-336510-qzm9wgde	528	46	control	control	NN
cord-336510-qzm9wgde	528	47	of	of	IN
cord-336510-qzm9wgde	528	48	HSV	HSV	NNP
cord-336510-qzm9wgde	528	49	infection	infection	NN
cord-336510-qzm9wgde	528	50	in	in	IN
cord-336510-qzm9wgde	528	51	peripheral	peripheral	JJ
cord-336510-qzm9wgde	528	52	nervous	nervous	JJ
cord-336510-qzm9wgde	528	53	tissue	tissue	NN
cord-336510-qzm9wgde	528	54	[	[	-LRB-
cord-336510-qzm9wgde	528	55	409	409	CD
cord-336510-qzm9wgde	528	56	]	]	-RRB-
cord-336510-qzm9wgde	528	57	.	.	.
cord-336510-qzm9wgde	529	1	The	the	DT
cord-336510-qzm9wgde	529	2	induction	induction	NN
cord-336510-qzm9wgde	529	3	of	of	IN
cord-336510-qzm9wgde	529	4	iNOS	inos	NN
cord-336510-qzm9wgde	529	5	and	and	CC
cord-336510-qzm9wgde	529	6	the	the	DT
cord-336510-qzm9wgde	529	7	following	follow	VBG
cord-336510-qzm9wgde	529	8	production	production	NN
cord-336510-qzm9wgde	529	9	of	of	IN
cord-336510-qzm9wgde	529	10	NO	no	DT
cord-336510-qzm9wgde	529	11	in	in	IN
cord-336510-qzm9wgde	529	12	response	response	NN
cord-336510-qzm9wgde	529	13	to	to	IN
cord-336510-qzm9wgde	529	14	IFN	IFN	NNP
cord-336510-qzm9wgde	529	15	-	-	HYPH
cord-336510-qzm9wgde	529	16	γ	γ	NNP
cord-336510-qzm9wgde	529	17	and	and	CC
cord-336510-qzm9wgde	529	18	HSV	HSV	NNP
cord-336510-qzm9wgde	529	19	is	be	VBZ
cord-336510-qzm9wgde	529	20	a	a	DT
cord-336510-qzm9wgde	529	21	relatively	relatively	RB
cord-336510-qzm9wgde	529	22	slow	slow	JJ
cord-336510-qzm9wgde	529	23	reaction	reaction	NN
cord-336510-qzm9wgde	529	24	,	,	,
cord-336510-qzm9wgde	529	25	coming	come	VBG
cord-336510-qzm9wgde	529	26	up	up	RP
cord-336510-qzm9wgde	529	27	after	after	IN
cord-336510-qzm9wgde	529	28	about	about	RB
cord-336510-qzm9wgde	529	29	18	18	CD
cord-336510-qzm9wgde	529	30	hours	hour	NNS
cord-336510-qzm9wgde	529	31	of	of	IN
cord-336510-qzm9wgde	529	32	infection	infection	NN
cord-336510-qzm9wgde	529	33	[	[	-LRB-
cord-336510-qzm9wgde	529	34	405	405	CD
cord-336510-qzm9wgde	529	35	]	]	-RRB-
cord-336510-qzm9wgde	529	36	.	.	.
cord-336510-qzm9wgde	530	1	In	in	IN
cord-336510-qzm9wgde	530	2	in	in	IN
cord-336510-qzm9wgde	530	3	vivo	vivo	NN
cord-336510-qzm9wgde	530	4	vaginal	vaginal	JJ
cord-336510-qzm9wgde	530	5	HSV	HSV	NNP
cord-336510-qzm9wgde	530	6	infections	infection	NNS
cord-336510-qzm9wgde	530	7	iNOS	inos	IN
cord-336510-qzm9wgde	530	8	mRNA	mrna	NN
cord-336510-qzm9wgde	530	9	could	could	MD
cord-336510-qzm9wgde	530	10	be	be	VB
cord-336510-qzm9wgde	530	11	detected	detect	VBN
cord-336510-qzm9wgde	530	12	after	after	IN
cord-336510-qzm9wgde	530	13	24	24	CD
cord-336510-qzm9wgde	530	14	hours	hour	NNS
cord-336510-qzm9wgde	530	15	of	of	IN
cord-336510-qzm9wgde	530	16	infection	infection	NN
cord-336510-qzm9wgde	530	17	[	[	-LRB-
cord-336510-qzm9wgde	530	18	410	410	CD
cord-336510-qzm9wgde	530	19	]	]	-RRB-
cord-336510-qzm9wgde	530	20	.	.	.
cord-336510-qzm9wgde	531	1	Thus	thus	RB
cord-336510-qzm9wgde	531	2	,	,	,
cord-336510-qzm9wgde	531	3	the	the	DT
cord-336510-qzm9wgde	531	4	production	production	NN
cord-336510-qzm9wgde	531	5	of	of	IN
cord-336510-qzm9wgde	531	6	this	this	DT
cord-336510-qzm9wgde	531	7	relatively	relatively	RB
cord-336510-qzm9wgde	531	8	toxic	toxic	JJ
cord-336510-qzm9wgde	531	9	substance	substance	NN
cord-336510-qzm9wgde	531	10	is	be	VBZ
cord-336510-qzm9wgde	531	11	part	part	NN
cord-336510-qzm9wgde	531	12	of	of	IN
cord-336510-qzm9wgde	531	13	the	the	DT
cord-336510-qzm9wgde	531	14	second	second	JJ
cord-336510-qzm9wgde	531	15	wave	wave	NN
cord-336510-qzm9wgde	531	16	of	of	IN
cord-336510-qzm9wgde	531	17	innate	innate	JJ
cord-336510-qzm9wgde	531	18	defence	defence	NN
cord-336510-qzm9wgde	531	19	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	531	20	.	.	.
cord-336510-qzm9wgde	532	1	The	the	DT
cord-336510-qzm9wgde	532	2	retarded	retarded	JJ
cord-336510-qzm9wgde	532	3	production	production	NN
cord-336510-qzm9wgde	532	4	of	of	IN
cord-336510-qzm9wgde	532	5	NO	no	NN
cord-336510-qzm9wgde	532	6	and	and	CC
cord-336510-qzm9wgde	532	7	the	the	DT
cord-336510-qzm9wgde	532	8	requirement	requirement	NN
cord-336510-qzm9wgde	532	9	for	for	IN
cord-336510-qzm9wgde	532	10	two	two	CD
cord-336510-qzm9wgde	532	11	or	or	CC
cord-336510-qzm9wgde	532	12	more	more	JJR
cord-336510-qzm9wgde	532	13	signals	signal	NNS
cord-336510-qzm9wgde	532	14	for	for	IN
cord-336510-qzm9wgde	532	15	induction	induction	NN
cord-336510-qzm9wgde	532	16	of	of	IN
cord-336510-qzm9wgde	532	17	iNOS	ino	NNS
cord-336510-qzm9wgde	532	18	are	be	VBP
cord-336510-qzm9wgde	532	19	logic	logic	NN
cord-336510-qzm9wgde	532	20	considering	consider	VBG
cord-336510-qzm9wgde	533	1	the	the	DT
cord-336510-qzm9wgde	533	2	In	in	IN
cord-336510-qzm9wgde	533	3	HSV	HSV	NNP
cord-336510-qzm9wgde	533	4	-	-	HYPH
cord-336510-qzm9wgde	533	5	infected	infect	VBN
cord-336510-qzm9wgde	533	6	macrophages	macrophage	NNS
cord-336510-qzm9wgde	533	7	exposed	expose	VBN
cord-336510-qzm9wgde	533	8	to	to	IN
cord-336510-qzm9wgde	533	9	IFN	IFN	NNP
cord-336510-qzm9wgde	533	10	-	-	HYPH
cord-336510-qzm9wgde	533	11	γ	γ	NNP
cord-336510-qzm9wgde	533	12	,	,	,
cord-336510-qzm9wgde	533	13	iNOS	iNOS	NNP
cord-336510-qzm9wgde	533	14	is	be	VBZ
cord-336510-qzm9wgde	533	15	induced	induce	VBN
cord-336510-qzm9wgde	533	16	synergistically	synergistically	RB
cord-336510-qzm9wgde	533	17	though	though	IN
cord-336510-qzm9wgde	533	18	TNF	TNF	NNP
cord-336510-qzm9wgde	533	19	-	-	HYPH
cord-336510-qzm9wgde	533	20	induced	induce	VBN
cord-336510-qzm9wgde	533	21	NF	NF	NNP
cord-336510-qzm9wgde	533	22	-	-	HYPH
cord-336510-qzm9wgde	533	23	κB	κb	CD
cord-336510-qzm9wgde	533	24	activation	activation	NN
cord-336510-qzm9wgde	533	25	and	and	CC
cord-336510-qzm9wgde	533	26	translocation	translocation	NN
cord-336510-qzm9wgde	533	27	to	to	IN
cord-336510-qzm9wgde	533	28	the	the	DT
cord-336510-qzm9wgde	533	29	nucleus	nucleus	NN
cord-336510-qzm9wgde	533	30	,	,	,
cord-336510-qzm9wgde	533	31	as	as	IN
cord-336510-qzm9wgde	533	32	shown	show	VBN
cord-336510-qzm9wgde	533	33	by	by	IN
cord-336510-qzm9wgde	533	34	binding	bind	VBG
cord-336510-qzm9wgde	533	35	of	of	IN
cord-336510-qzm9wgde	533	36	a	a	DT
cord-336510-qzm9wgde	533	37	heterodimeric	heterodimeric	JJ
cord-336510-qzm9wgde	533	38	complex	complex	NN
cord-336510-qzm9wgde	533	39	of	of	IN
cord-336510-qzm9wgde	533	40	p55	p55	NN
cord-336510-qzm9wgde	533	41	/	/	SYM
cord-336510-qzm9wgde	533	42	p65	p65	NN
cord-336510-qzm9wgde	533	43	and	and	CC
cord-336510-qzm9wgde	533	44	a	a	DT
cord-336510-qzm9wgde	533	45	homodimer	homodimer	NN
cord-336510-qzm9wgde	533	46	of	of	IN
cord-336510-qzm9wgde	533	47	p55	p55	NN
cord-336510-qzm9wgde	533	48	to	to	IN
cord-336510-qzm9wgde	533	49	the	the	DT
cord-336510-qzm9wgde	533	50	κB	κB	NNP
cord-336510-qzm9wgde	533	51	-	-	HYPH
cord-336510-qzm9wgde	533	52	site	site	NN
cord-336510-qzm9wgde	533	53	of	of	IN
cord-336510-qzm9wgde	533	54	the	the	DT
cord-336510-qzm9wgde	533	55	iNOS	inos	JJ
cord-336510-qzm9wgde	533	56	promoter	promoter	NN
cord-336510-qzm9wgde	533	57	during	during	IN
cord-336510-qzm9wgde	533	58	infection	infection	NN
cord-336510-qzm9wgde	533	59	[	[	-LRB-
cord-336510-qzm9wgde	533	60	325	325	CD
cord-336510-qzm9wgde	533	61	]	]	-RRB-
cord-336510-qzm9wgde	533	62	.	.	.
cord-336510-qzm9wgde	534	1	The	the	DT
cord-336510-qzm9wgde	534	2	crucial	crucial	JJ
cord-336510-qzm9wgde	534	3	position	position	NN
cord-336510-qzm9wgde	534	4	of	of	IN
cord-336510-qzm9wgde	534	5	NF	nf	NN
cord-336510-qzm9wgde	534	6	-	-	HYPH
cord-336510-qzm9wgde	534	7	κB	κB	NNP
cord-336510-qzm9wgde	534	8	in	in	IN
cord-336510-qzm9wgde	534	9	the	the	DT
cord-336510-qzm9wgde	534	10	induction	induction	NN
cord-336510-qzm9wgde	534	11	of	of	IN
cord-336510-qzm9wgde	534	12	iNOS	inos	NN
cord-336510-qzm9wgde	534	13	and	and	CC
cord-336510-qzm9wgde	534	14	production	production	NN
cord-336510-qzm9wgde	534	15	of	of	IN
cord-336510-qzm9wgde	534	16	NO	no	DT
cord-336510-qzm9wgde	534	17	is	be	VBZ
cord-336510-qzm9wgde	534	18	also	also	RB
cord-336510-qzm9wgde	534	19	indicated	indicate	VBN
cord-336510-qzm9wgde	534	20	by	by	IN
cord-336510-qzm9wgde	534	21	experiments	experiment	NNS
cord-336510-qzm9wgde	534	22	showing	show	VBG
cord-336510-qzm9wgde	534	23	that	that	IN
cord-336510-qzm9wgde	534	24	antibodies	antibody	NNS
cord-336510-qzm9wgde	534	25	to	to	IN
cord-336510-qzm9wgde	534	26	TNF	TNF	NNP
cord-336510-qzm9wgde	534	27	inhibit	inhibit	VB
cord-336510-qzm9wgde	534	28	activation	activation	NN
cord-336510-qzm9wgde	534	29	of	of	IN
cord-336510-qzm9wgde	534	30	NF	nf	NN
cord-336510-qzm9wgde	534	31	-	-	HYPH
cord-336510-qzm9wgde	534	32	κB	κb	NN
cord-336510-qzm9wgde	534	33	and	and	CC
cord-336510-qzm9wgde	534	34	production	production	NN
cord-336510-qzm9wgde	534	35	of	of	IN
cord-336510-qzm9wgde	534	36	NO	no	DT
cord-336510-qzm9wgde	534	37	in	in	IN
cord-336510-qzm9wgde	534	38	HSVinfected	hsvinfecte	VBN
cord-336510-qzm9wgde	534	39	cells	cell	NNS
cord-336510-qzm9wgde	534	40	and	and	CC
cord-336510-qzm9wgde	534	41	abolish	abolish	VB
cord-336510-qzm9wgde	534	42	the	the	DT
cord-336510-qzm9wgde	534	43	synergism	synergism	NN
cord-336510-qzm9wgde	534	44	between	between	IN
cord-336510-qzm9wgde	534	45	the	the	DT
cord-336510-qzm9wgde	534	46	virus	virus	NN
cord-336510-qzm9wgde	534	47	and	and	CC
cord-336510-qzm9wgde	534	48	IFN	IFN	NNP
cord-336510-qzm9wgde	534	49	-	-	HYPH
cord-336510-qzm9wgde	534	50	γ	γ	NNP
cord-336510-qzm9wgde	534	51	,	,	,
cord-336510-qzm9wgde	534	52	an	an	DT
cord-336510-qzm9wgde	534	53	observation	observation	NN
cord-336510-qzm9wgde	534	54	which	which	WDT
cord-336510-qzm9wgde	534	55	was	be	VBD
cord-336510-qzm9wgde	534	56	also	also	RB
cord-336510-qzm9wgde	534	57	seen	see	VBN
cord-336510-qzm9wgde	534	58	with	with	IN
cord-336510-qzm9wgde	534	59	inhibitors	inhibitor	NNS
cord-336510-qzm9wgde	534	60	of	of	IN
cord-336510-qzm9wgde	534	61	NF	nf	NN
cord-336510-qzm9wgde	534	62	-	-	HYPH
cord-336510-qzm9wgde	534	63	κB	κb	CD
cord-336510-qzm9wgde	534	64	activation	activation	NN
cord-336510-qzm9wgde	534	65	[	[	-LRB-
cord-336510-qzm9wgde	534	66	325	325	CD
cord-336510-qzm9wgde	534	67	]	]	-RRB-
cord-336510-qzm9wgde	534	68	.	.	.
cord-336510-qzm9wgde	535	1	Further	further	JJ
cord-336510-qzm9wgde	535	2	analysis	analysis	NN
cord-336510-qzm9wgde	535	3	of	of	IN
cord-336510-qzm9wgde	535	4	the	the	DT
cord-336510-qzm9wgde	535	5	signalling	signal	VBG
cord-336510-qzm9wgde	535	6	mechanism	mechanism	NN
cord-336510-qzm9wgde	535	7	has	have	VBZ
cord-336510-qzm9wgde	535	8	revealed	reveal	VBN
cord-336510-qzm9wgde	535	9	that	that	IN
cord-336510-qzm9wgde	535	10	the	the	DT
cord-336510-qzm9wgde	535	11	synergism	synergism	NN
cord-336510-qzm9wgde	535	12	upon	upon	IN
cord-336510-qzm9wgde	535	13	HSV	HSV	NNP
cord-336510-qzm9wgde	535	14	infection	infection	NN
cord-336510-qzm9wgde	535	15	is	be	VBZ
cord-336510-qzm9wgde	535	16	influenced	influence	VBN
cord-336510-qzm9wgde	535	17	by	by	IN
cord-336510-qzm9wgde	535	18	physical	physical	JJ
cord-336510-qzm9wgde	535	19	interaction	interaction	NN
cord-336510-qzm9wgde	535	20	of	of	IN
cord-336510-qzm9wgde	535	21	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	535	22	and	and	CC
cord-336510-qzm9wgde	535	23	the	the	DT
cord-336510-qzm9wgde	535	24	NF	NF	NNP
cord-336510-qzm9wgde	535	25	-	-	HYPH
cord-336510-qzm9wgde	535	26	κB	κb	CD
cord-336510-qzm9wgde	535	27	subunit	subunit	NN
cord-336510-qzm9wgde	535	28	p65	p65	NN
cord-336510-qzm9wgde	535	29	and	and	CC
cord-336510-qzm9wgde	535	30	controlled	control	VBN
cord-336510-qzm9wgde	535	31	by	by	IN
cord-336510-qzm9wgde	535	32	the	the	DT
cord-336510-qzm9wgde	535	33	ISREsite	ISREsite	NNP
cord-336510-qzm9wgde	535	34	and	and	CC
cord-336510-qzm9wgde	535	35	the	the	DT
cord-336510-qzm9wgde	535	36	distal	distal	JJ
cord-336510-qzm9wgde	535	37	κB	κB	NNP
cord-336510-qzm9wgde	535	38	-	-	HYPH
cord-336510-qzm9wgde	535	39	site	site	NN
cord-336510-qzm9wgde	535	40	of	of	IN
cord-336510-qzm9wgde	535	41	the	the	DT
cord-336510-qzm9wgde	535	42	iNOS	inos	CD
cord-336510-qzm9wgde	535	43	promoter	promoter	NN
cord-336510-qzm9wgde	535	44	(	(	-LRB-
cord-336510-qzm9wgde	535	45	fig	fig	NN
cord-336510-qzm9wgde	535	46	.	.	.
cord-336510-qzm9wgde	535	47	5	5	LS
cord-336510-qzm9wgde	535	48	)	)	-RRB-
cord-336510-qzm9wgde	536	1	[	[	-LRB-
cord-336510-qzm9wgde	536	2	411	411	CD
cord-336510-qzm9wgde	536	3	]	]	-RRB-
cord-336510-qzm9wgde	536	4	.	.	.
cord-336510-qzm9wgde	537	1	A	a	DT
cord-336510-qzm9wgde	537	2	further	further	JJ
cord-336510-qzm9wgde	537	3	support	support	NN
cord-336510-qzm9wgde	537	4	for	for	IN
cord-336510-qzm9wgde	537	5	this	this	DT
cord-336510-qzm9wgde	537	6	notion	notion	NN
cord-336510-qzm9wgde	537	7	comes	come	VBZ
cord-336510-qzm9wgde	537	8	from	from	IN
cord-336510-qzm9wgde	537	9	the	the	DT
cord-336510-qzm9wgde	537	10	observation	observation	NN
cord-336510-qzm9wgde	537	11	that	that	IN
cord-336510-qzm9wgde	537	12	the	the	DT
cord-336510-qzm9wgde	537	13	DNA	dna	NN
cord-336510-qzm9wgde	537	14	-	-	HYPH
cord-336510-qzm9wgde	537	15	binding	bind	VBG
cord-336510-qzm9wgde	537	16	capacity	capacity	NN
cord-336510-qzm9wgde	537	17	of	of	IN
cord-336510-qzm9wgde	537	18	NF	nf	NN
cord-336510-qzm9wgde	537	19	-	-	HYPH
cord-336510-qzm9wgde	537	20	κB	κB	NNP
cord-336510-qzm9wgde	537	21	and	and	CC
cord-336510-qzm9wgde	537	22	the	the	DT
cord-336510-qzm9wgde	537	23	nuclear	nuclear	JJ
cord-336510-qzm9wgde	537	24	translocation	translocation	NN
cord-336510-qzm9wgde	537	25	of	of	IN
cord-336510-qzm9wgde	537	26	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	537	27	have	have	VBP
cord-336510-qzm9wgde	537	28	similar	similar	JJ
cord-336510-qzm9wgde	537	29	kinetics	kinetic	NNS
cord-336510-qzm9wgde	537	30	upon	upon	IN
cord-336510-qzm9wgde	537	31	HSV	HSV	NNP
cord-336510-qzm9wgde	537	32	infection	infection	NN
cord-336510-qzm9wgde	537	33	[	[	-LRB-
cord-336510-qzm9wgde	537	34	411	411	CD
cord-336510-qzm9wgde	537	35	]	]	-RRB-
cord-336510-qzm9wgde	537	36	and	and	CC
cord-336510-qzm9wgde	537	37	the	the	DT
cord-336510-qzm9wgde	537	38	fact	fact	NN
cord-336510-qzm9wgde	537	39	that	that	IN
cord-336510-qzm9wgde	537	40	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	537	41	is	be	VBZ
cord-336510-qzm9wgde	537	42	essential	essential	JJ
cord-336510-qzm9wgde	537	43	for	for	IN
cord-336510-qzm9wgde	537	44	iNOS	inos	JJ
cord-336510-qzm9wgde	537	45	induction	induction	NN
cord-336510-qzm9wgde	537	46	[	[	-LRB-
cord-336510-qzm9wgde	537	47	412	412	CD
cord-336510-qzm9wgde	537	48	]	]	-RRB-
cord-336510-qzm9wgde	537	49	.	.	.
cord-336510-qzm9wgde	538	1	Induction	induction	NN
cord-336510-qzm9wgde	538	2	of	of	IN
cord-336510-qzm9wgde	538	3	other	other	JJ
cord-336510-qzm9wgde	538	4	genes	gene	NNS
cord-336510-qzm9wgde	538	5	such	such	JJ
cord-336510-qzm9wgde	538	6	as	as	IN
cord-336510-qzm9wgde	538	7	IFN	IFN	NNP
cord-336510-qzm9wgde	538	8	-	-	HYPH
cord-336510-qzm9wgde	538	9	β	β	NNP
cord-336510-qzm9wgde	538	10	and	and	CC
cord-336510-qzm9wgde	538	11	vascular	vascular	JJ
cord-336510-qzm9wgde	538	12	cell	cell	NN
cord-336510-qzm9wgde	538	13	adhesion	adhesion	NN
cord-336510-qzm9wgde	538	14	molecule	molecule	NN
cord-336510-qzm9wgde	538	15	1	1	CD
cord-336510-qzm9wgde	538	16	also	also	RB
cord-336510-qzm9wgde	538	17	involve	involve	VBP
cord-336510-qzm9wgde	538	18	physical	physical	JJ
cord-336510-qzm9wgde	538	19	interaction	interaction	NN
cord-336510-qzm9wgde	538	20	of	of	IN
cord-336510-qzm9wgde	538	21	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	538	22	and	and	CC
cord-336510-qzm9wgde	538	23	NF	NF	NNP
cord-336510-qzm9wgde	538	24	-	-	HYPH
cord-336510-qzm9wgde	538	25	κB	κB	NNP
cord-336510-qzm9wgde	538	26	[	[	-LRB-
cord-336510-qzm9wgde	538	27	413	413	CD
cord-336510-qzm9wgde	538	28	]	]	-RRB-
cord-336510-qzm9wgde	538	29	,	,	,
cord-336510-qzm9wgde	538	30	and	and	CC
cord-336510-qzm9wgde	538	31	both	both	CC
cord-336510-qzm9wgde	538	32	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	538	33	and	and	CC
cord-336510-qzm9wgde	538	34	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	538	35	have	have	VBP
cord-336510-qzm9wgde	538	36	in	in	IN
cord-336510-qzm9wgde	538	37	other	other	JJ
cord-336510-qzm9wgde	538	38	cells	cell	NNS
cord-336510-qzm9wgde	538	39	types	type	NNS
cord-336510-qzm9wgde	538	40	been	be	VBN
cord-336510-qzm9wgde	538	41	shown	show	VBN
cord-336510-qzm9wgde	538	42	to	to	TO
cord-336510-qzm9wgde	538	43	form	form	VB
cord-336510-qzm9wgde	538	44	complexes	complex	NNS
cord-336510-qzm9wgde	538	45	with	with	IN
cord-336510-qzm9wgde	538	46	NF	nf	NN
cord-336510-qzm9wgde	538	47	-	-	HYPH
cord-336510-qzm9wgde	538	48	κB	κB	NNP
cord-336510-qzm9wgde	538	49	[	[	-LRB-
cord-336510-qzm9wgde	538	50	414	414	CD
cord-336510-qzm9wgde	538	51	,	,	,
cord-336510-qzm9wgde	538	52	415	415	CD
cord-336510-qzm9wgde	538	53	]	]	-RRB-
cord-336510-qzm9wgde	538	54	.	.	.
cord-336510-qzm9wgde	539	1	Another	another	DT
cord-336510-qzm9wgde	539	2	potential	potential	JJ
cord-336510-qzm9wgde	539	3	mechanism	mechanism	NN
cord-336510-qzm9wgde	539	4	in	in	IN
cord-336510-qzm9wgde	539	5	the	the	DT
cord-336510-qzm9wgde	539	6	synergistic	synergistic	JJ
cord-336510-qzm9wgde	539	7	induction	induction	NN
cord-336510-qzm9wgde	539	8	of	of	IN
cord-336510-qzm9wgde	539	9	iNOS	inos	NN
cord-336510-qzm9wgde	539	10	could	could	MD
cord-336510-qzm9wgde	539	11	involve	involve	VB
cord-336510-qzm9wgde	539	12	complex	complex	JJ
cord-336510-qzm9wgde	539	13	formation	formation	NN
cord-336510-qzm9wgde	539	14	of	of	IN
cord-336510-qzm9wgde	539	15	IFN	IFN	NNP
cord-336510-qzm9wgde	539	16	consensus	consensus	NN
cord-336510-qzm9wgde	539	17	sequence	sequence	NN
cord-336510-qzm9wgde	539	18	-	-	HYPH
cord-336510-qzm9wgde	539	19	binding	bind	VBG
cord-336510-qzm9wgde	539	20	protein	protein	NN
cord-336510-qzm9wgde	539	21	(	(	-LRB-
cord-336510-qzm9wgde	539	22	ICSBP	ICSBP	NNP
cord-336510-qzm9wgde	539	23	or	or	CC
cord-336510-qzm9wgde	539	24	IRF-8	IRF-8	NNP
cord-336510-qzm9wgde	539	25	)	)	-RRB-
cord-336510-qzm9wgde	539	26	and	and	CC
cord-336510-qzm9wgde	539	27	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	539	28	,	,	,
cord-336510-qzm9wgde	539	29	which	which	WDT
cord-336510-qzm9wgde	539	30	is	be	VBZ
cord-336510-qzm9wgde	539	31	also	also	RB
cord-336510-qzm9wgde	539	32	important	important	JJ
cord-336510-qzm9wgde	539	33	for	for	IN
cord-336510-qzm9wgde	539	34	high	high	JJ
cord-336510-qzm9wgde	539	35	-	-	HYPH
cord-336510-qzm9wgde	539	36	output	output	NN
cord-336510-qzm9wgde	539	37	NO	no	DT
cord-336510-qzm9wgde	539	38	production	production	NN
cord-336510-qzm9wgde	539	39	but	but	CC
cord-336510-qzm9wgde	539	40	has	have	VBZ
cord-336510-qzm9wgde	539	41	still	still	RB
cord-336510-qzm9wgde	539	42	not	not	RB
cord-336510-qzm9wgde	539	43	been	be	VBN
cord-336510-qzm9wgde	539	44	studied	study	VBN
cord-336510-qzm9wgde	539	45	in	in	IN
cord-336510-qzm9wgde	539	46	HSV	HSV	NNP
cord-336510-qzm9wgde	539	47	infections	infection	NNS
cord-336510-qzm9wgde	539	48	[	[	-LRB-
cord-336510-qzm9wgde	539	49	416	416	CD
cord-336510-qzm9wgde	539	50	]	]	-RRB-
cord-336510-qzm9wgde	539	51	.	.	.
cord-336510-qzm9wgde	540	1	Thus	thus	RB
cord-336510-qzm9wgde	540	2	,	,	,
cord-336510-qzm9wgde	540	3	high	high	JJ
cord-336510-qzm9wgde	540	4	-	-	HYPH
cord-336510-qzm9wgde	540	5	output	output	NN
cord-336510-qzm9wgde	540	6	NO	no	DT
cord-336510-qzm9wgde	540	7	production	production	NN
cord-336510-qzm9wgde	540	8	from	from	IN
cord-336510-qzm9wgde	540	9	activated	activate	VBN
cord-336510-qzm9wgde	540	10	macrophages	macrophage	NNS
cord-336510-qzm9wgde	540	11	is	be	VBZ
cord-336510-qzm9wgde	540	12	controlled	control	VBN
cord-336510-qzm9wgde	540	13	by	by	IN
cord-336510-qzm9wgde	540	14	a	a	DT
cord-336510-qzm9wgde	540	15	"	"	``
cord-336510-qzm9wgde	540	16	double	double	JJ
cord-336510-qzm9wgde	540	17	-	-	HYPH
cord-336510-qzm9wgde	540	18	lock	lock	NN
cord-336510-qzm9wgde	540	19	"	"	''
cord-336510-qzm9wgde	540	20	signalling	signalling	NN
cord-336510-qzm9wgde	540	21	mechanism	mechanism	NN
cord-336510-qzm9wgde	540	22	restricting	restrict	VBG
cord-336510-qzm9wgde	540	23	the	the	DT
cord-336510-qzm9wgde	540	24	production	production	NN
cord-336510-qzm9wgde	540	25	of	of	IN
cord-336510-qzm9wgde	540	26	this	this	DT
cord-336510-qzm9wgde	540	27	antiviral	antiviral	JJ
cord-336510-qzm9wgde	540	28	toxic	toxic	JJ
cord-336510-qzm9wgde	540	29	substance	substance	NN
cord-336510-qzm9wgde	540	30	to	to	IN
cord-336510-qzm9wgde	540	31	sites	site	NNS
cord-336510-qzm9wgde	540	32	of	of	IN
cord-336510-qzm9wgde	540	33	active	active	JJ
cord-336510-qzm9wgde	540	34	viral	viral	JJ
cord-336510-qzm9wgde	540	35	replication	replication	NN
cord-336510-qzm9wgde	540	36	,	,	,
cord-336510-qzm9wgde	540	37	and	and	CC
cord-336510-qzm9wgde	540	38	sparing	spare	VBG
cord-336510-qzm9wgde	540	39	uninfected	uninfected	JJ
cord-336510-qzm9wgde	540	40	tissue	tissue	NN
cord-336510-qzm9wgde	540	41	from	from	IN
cord-336510-qzm9wgde	540	42	the	the	DT
cord-336510-qzm9wgde	540	43	detrimental	detrimental	JJ
cord-336510-qzm9wgde	540	44	effects	effect	NNS
cord-336510-qzm9wgde	540	45	(	(	-LRB-
cord-336510-qzm9wgde	540	46	fig	fig	NN
cord-336510-qzm9wgde	540	47	.	.	.
cord-336510-qzm9wgde	540	48	4	4	LS
cord-336510-qzm9wgde	540	49	)	)	-RRB-
cord-336510-qzm9wgde	540	50	.	.	.
cord-336510-qzm9wgde	541	1	The	the	DT
cord-336510-qzm9wgde	541	2	antiviral	antiviral	JJ
cord-336510-qzm9wgde	541	3	effects	effect	NNS
cord-336510-qzm9wgde	541	4	of	of	IN
cord-336510-qzm9wgde	541	5	NO	no	DT
cord-336510-qzm9wgde	541	6	have	have	VBP
cord-336510-qzm9wgde	541	7	been	be	VBN
cord-336510-qzm9wgde	541	8	documented	document	VBN
cord-336510-qzm9wgde	541	9	in	in	IN
cord-336510-qzm9wgde	541	10	several	several	JJ
cord-336510-qzm9wgde	541	11	viral	viral	JJ
cord-336510-qzm9wgde	541	12	infections	infection	NNS
cord-336510-qzm9wgde	541	13	,	,	,
cord-336510-qzm9wgde	541	14	although	although	IN
cord-336510-qzm9wgde	541	15	there	there	EX
cord-336510-qzm9wgde	541	16	clearly	clearly	RB
cord-336510-qzm9wgde	541	17	exist	exist	VBP
cord-336510-qzm9wgde	541	18	viruses	virus	NNS
cord-336510-qzm9wgde	541	19	and	and	CC
cord-336510-qzm9wgde	541	20	conditions	condition	NNS
cord-336510-qzm9wgde	541	21	where	where	WRB
cord-336510-qzm9wgde	541	22	NO	no	DT
cord-336510-qzm9wgde	541	23	does	do	VBZ
cord-336510-qzm9wgde	541	24	not	not	RB
cord-336510-qzm9wgde	541	25	exhibit	exhibit	VB
cord-336510-qzm9wgde	541	26	major	major	JJ
cord-336510-qzm9wgde	541	27	antiviral	antiviral	JJ
cord-336510-qzm9wgde	541	28	properties	property	NNS
cord-336510-qzm9wgde	541	29	.	.	.
cord-336510-qzm9wgde	542	1	NO	no	UH
cord-336510-qzm9wgde	542	2	is	be	VBZ
cord-336510-qzm9wgde	542	3	thus	thus	RB
cord-336510-qzm9wgde	542	4	not	not	RB
cord-336510-qzm9wgde	542	5	a	a	DT
cord-336510-qzm9wgde	542	6	magic	magic	JJ
cord-336510-qzm9wgde	542	7	bullet	bullet	NN
cord-336510-qzm9wgde	542	8	against	against	IN
cord-336510-qzm9wgde	542	9	virus	virus	NN
cord-336510-qzm9wgde	542	10	infections	infection	NNS
cord-336510-qzm9wgde	542	11	[	[	-LRB-
cord-336510-qzm9wgde	542	12	417	417	CD
cord-336510-qzm9wgde	542	13	]	]	-RRB-
cord-336510-qzm9wgde	542	14	.	.	.
cord-336510-qzm9wgde	543	1	In	in	IN
cord-336510-qzm9wgde	543	2	HSV	HSV	NNP
cord-336510-qzm9wgde	543	3	infections	infection	NNS
cord-336510-qzm9wgde	543	4	,	,	,
cord-336510-qzm9wgde	543	5	NO	NO	NNP
cord-336510-qzm9wgde	543	6	has	have	VBZ
cord-336510-qzm9wgde	543	7	been	be	VBN
cord-336510-qzm9wgde	543	8	shown	show	VBN
cord-336510-qzm9wgde	543	9	to	to	TO
cord-336510-qzm9wgde	543	10	confer	confer	VB
cord-336510-qzm9wgde	543	11	a	a	DT
cord-336510-qzm9wgde	543	12	substantial	substantial	JJ
cord-336510-qzm9wgde	543	13	part	part	NN
cord-336510-qzm9wgde	543	14	of	of	IN
cord-336510-qzm9wgde	543	15	the	the	DT
cord-336510-qzm9wgde	543	16	antiviral	antiviral	JJ
cord-336510-qzm9wgde	543	17	activity	activity	NN
cord-336510-qzm9wgde	543	18	induced	induce	VBN
cord-336510-qzm9wgde	543	19	by	by	IN
cord-336510-qzm9wgde	543	20	IFN	IFN	NNP
cord-336510-qzm9wgde	543	21	-	-	HYPH
cord-336510-qzm9wgde	543	22	γ	γ	NNP
cord-336510-qzm9wgde	543	23	in	in	IN
cord-336510-qzm9wgde	543	24	a	a	DT
cord-336510-qzm9wgde	543	25	macrophage	macrophage	NN
cord-336510-qzm9wgde	543	26	cell	cell	NN
cord-336510-qzm9wgde	543	27	line	line	NN
cord-336510-qzm9wgde	543	28	and	and	CC
cord-336510-qzm9wgde	543	29	to	to	TO
cord-336510-qzm9wgde	543	30	participate	participate	VB
cord-336510-qzm9wgde	543	31	in	in	IN
cord-336510-qzm9wgde	543	32	the	the	DT
cord-336510-qzm9wgde	543	33	extrinsic	extrinsic	JJ
cord-336510-qzm9wgde	543	34	anti	anti	JJ
cord-336510-qzm9wgde	543	35	-	-	JJ
cord-336510-qzm9wgde	543	36	HSV	hsv	JJ
cord-336510-qzm9wgde	543	37	effect	effect	NN
cord-336510-qzm9wgde	543	38	of	of	IN
cord-336510-qzm9wgde	543	39	macrophages	macrophage	NNS
cord-336510-qzm9wgde	543	40	[	[	-LRB-
cord-336510-qzm9wgde	543	41	418	418	CD
cord-336510-qzm9wgde	543	42	]	]	-RRB-
cord-336510-qzm9wgde	543	43	[	[	-LRB-
cord-336510-qzm9wgde	543	44	419	419	CD
cord-336510-qzm9wgde	543	45	]	]	-RRB-
cord-336510-qzm9wgde	543	46	[	[	-LRB-
cord-336510-qzm9wgde	543	47	420	420	CD
cord-336510-qzm9wgde	543	48	]	]	-RRB-
cord-336510-qzm9wgde	543	49	[	[	-LRB-
cord-336510-qzm9wgde	543	50	421	421	CD
cord-336510-qzm9wgde	543	51	]	]	-RRB-
cord-336510-qzm9wgde	543	52	.	.	.
cord-336510-qzm9wgde	544	1	An	an	DT
cord-336510-qzm9wgde	544	2	exogenously	exogenously	RB
cord-336510-qzm9wgde	544	3	added	add	VBN
cord-336510-qzm9wgde	544	4	donor	donor	NN
cord-336510-qzm9wgde	544	5	of	of	IN
cord-336510-qzm9wgde	544	6	NO	no	DT
cord-336510-qzm9wgde	544	7	has	have	VBZ
cord-336510-qzm9wgde	544	8	in	in	IN
cord-336510-qzm9wgde	544	9	several	several	JJ
cord-336510-qzm9wgde	544	10	cell	cell	NN
cord-336510-qzm9wgde	544	11	lines	line	NNS
cord-336510-qzm9wgde	544	12	been	be	VBN
cord-336510-qzm9wgde	544	13	shown	show	VBN
cord-336510-qzm9wgde	544	14	to	to	TO
cord-336510-qzm9wgde	544	15	reduce	reduce	VB
cord-336510-qzm9wgde	544	16	the	the	DT
cord-336510-qzm9wgde	544	17	replication	replication	NN
cord-336510-qzm9wgde	544	18	of	of	IN
cord-336510-qzm9wgde	544	19	HSV	HSV	NNP
cord-336510-qzm9wgde	544	20	[	[	-LRB-
cord-336510-qzm9wgde	544	21	422	422	CD
cord-336510-qzm9wgde	544	22	]	]	-RRB-
cord-336510-qzm9wgde	544	23	.	.	.
cord-336510-qzm9wgde	545	1	In	in	IN
cord-336510-qzm9wgde	545	2	vivo	vivo	NN
cord-336510-qzm9wgde	545	3	,	,	,
cord-336510-qzm9wgde	545	4	analysis	analysis	NN
cord-336510-qzm9wgde	545	5	of	of	IN
cord-336510-qzm9wgde	545	6	mice	mouse	NNS
cord-336510-qzm9wgde	545	7	treated	treat	VBN
cord-336510-qzm9wgde	545	8	with	with	IN
cord-336510-qzm9wgde	545	9	an	an	DT
cord-336510-qzm9wgde	545	10	inhibitor	inhibitor	NN
cord-336510-qzm9wgde	545	11	of	of	IN
cord-336510-qzm9wgde	545	12	NO	no	DT
cord-336510-qzm9wgde	545	13	production	production	NN
cord-336510-qzm9wgde	545	14	showed	show	VBD
cord-336510-qzm9wgde	545	15	higher	high	JJR
cord-336510-qzm9wgde	545	16	titres	titre	NNS
cord-336510-qzm9wgde	545	17	of	of	IN
cord-336510-qzm9wgde	545	18	HSV	HSV	NNP
cord-336510-qzm9wgde	545	19	in	in	IN
cord-336510-qzm9wgde	545	20	the	the	DT
cord-336510-qzm9wgde	545	21	lungs	lung	NNS
cord-336510-qzm9wgde	545	22	but	but	CC
cord-336510-qzm9wgde	545	23	increased	increase	VBN
cord-336510-qzm9wgde	545	24	survival	survival	NN
cord-336510-qzm9wgde	545	25	rates	rate	NNS
cord-336510-qzm9wgde	545	26	due	due	JJ
cord-336510-qzm9wgde	545	27	to	to	IN
cord-336510-qzm9wgde	545	28	reduced	reduce	VBN
cord-336510-qzm9wgde	545	29	inflammation	inflammation	NN
cord-336510-qzm9wgde	545	30	[	[	-LRB-
cord-336510-qzm9wgde	545	31	135	135	CD
cord-336510-qzm9wgde	545	32	]	]	-RRB-
cord-336510-qzm9wgde	545	33	.	.	.
cord-336510-qzm9wgde	546	1	Recently	recently	RB
cord-336510-qzm9wgde	546	2	,	,	,
cord-336510-qzm9wgde	546	3	a	a	DT
cord-336510-qzm9wgde	546	4	study	study	NN
cord-336510-qzm9wgde	546	5	using	use	VBG
cord-336510-qzm9wgde	546	6	another	another	DT
cord-336510-qzm9wgde	546	7	inhibitor	inhibitor	NN
cord-336510-qzm9wgde	546	8	of	of	IN
cord-336510-qzm9wgde	546	9	NO	no	DT
cord-336510-qzm9wgde	546	10	production	production	NN
cord-336510-qzm9wgde	546	11	has	have	VBZ
cord-336510-qzm9wgde	546	12	confirmed	confirm	VBN
cord-336510-qzm9wgde	546	13	the	the	DT
cord-336510-qzm9wgde	546	14	anti	anti	JJ
cord-336510-qzm9wgde	546	15	-	-	JJ
cord-336510-qzm9wgde	546	16	herpetic	herpetic	JJ
cord-336510-qzm9wgde	546	17	effect	effect	NN
cord-336510-qzm9wgde	546	18	of	of	IN
cord-336510-qzm9wgde	546	19	NO	no	NN
cord-336510-qzm9wgde	546	20	during	during	IN
cord-336510-qzm9wgde	546	21	a	a	DT
cord-336510-qzm9wgde	546	22	HSV	HSV	NNP
cord-336510-qzm9wgde	546	23	respiratory	respiratory	JJ
cord-336510-qzm9wgde	546	24	infection	infection	NN
cord-336510-qzm9wgde	546	25	,	,	,
cord-336510-qzm9wgde	546	26	but	but	CC
cord-336510-qzm9wgde	546	27	in	in	IN
cord-336510-qzm9wgde	546	28	this	this	DT
cord-336510-qzm9wgde	546	29	study	study	NN
cord-336510-qzm9wgde	546	30	mice	mouse	NNS
cord-336510-qzm9wgde	546	31	with	with	IN
cord-336510-qzm9wgde	546	32	inhibited	inhibit	VBN
cord-336510-qzm9wgde	546	33	NO	no	DT
cord-336510-qzm9wgde	546	34	production	production	NN
cord-336510-qzm9wgde	546	35	showed	show	VBD
cord-336510-qzm9wgde	546	36	increased	increase	VBN
cord-336510-qzm9wgde	546	37	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	546	38	responses	response	NNS
cord-336510-qzm9wgde	546	39	,	,	,
cord-336510-qzm9wgde	546	40	symptoms	symptom	NNS
cord-336510-qzm9wgde	546	41	of	of	IN
cord-336510-qzm9wgde	546	42	infection	infection	NN
cord-336510-qzm9wgde	546	43	,	,	,
cord-336510-qzm9wgde	546	44	and	and	CC
cord-336510-qzm9wgde	546	45	mortality	mortality	NN
cord-336510-qzm9wgde	546	46	IFN	IFN	NNP
cord-336510-qzm9wgde	546	47	-	-	HYPH
cord-336510-qzm9wgde	546	48	γ	γ	NN
cord-336510-qzm9wgde	546	49	IL-4	IL-4	NNP
cord-336510-qzm9wgde	546	50	(	(	-LRB-
cord-336510-qzm9wgde	546	51	at	at	IN
cord-336510-qzm9wgde	546	52	high	high	JJ
cord-336510-qzm9wgde	546	53	IFN	IFN	NNP
cord-336510-qzm9wgde	546	54	-	-	HYPH
cord-336510-qzm9wgde	546	55	γ	γ	NNP
cord-336510-qzm9wgde	546	56	/	/	SYM
cord-336510-qzm9wgde	546	57	STAT1	stat1	XX
cord-336510-qzm9wgde	546	58	)	)	-RRB-
cord-336510-qzm9wgde	546	59	[	[	-LRB-
cord-336510-qzm9wgde	546	60	423	423	CD
cord-336510-qzm9wgde	546	61	]	]	-RRB-
cord-336510-qzm9wgde	546	62	.	.	.
cord-336510-qzm9wgde	547	1	Replication	replication	NN
cord-336510-qzm9wgde	547	2	of	of	IN
cord-336510-qzm9wgde	547	3	HSV	HSV	NNP
cord-336510-qzm9wgde	547	4	during	during	IN
cord-336510-qzm9wgde	547	5	vaginal	vaginal	JJ
cord-336510-qzm9wgde	547	6	infection	infection	NN
cord-336510-qzm9wgde	547	7	was	be	VBD
cord-336510-qzm9wgde	547	8	increased	increase	VBN
cord-336510-qzm9wgde	547	9	in	in	IN
cord-336510-qzm9wgde	547	10	the	the	DT
cord-336510-qzm9wgde	547	11	presence	presence	NN
cord-336510-qzm9wgde	547	12	of	of	IN
cord-336510-qzm9wgde	547	13	an	an	DT
cord-336510-qzm9wgde	547	14	inhibitor	inhibitor	NN
cord-336510-qzm9wgde	547	15	of	of	IN
cord-336510-qzm9wgde	547	16	NO	no	DT
cord-336510-qzm9wgde	547	17	production	production	NN
cord-336510-qzm9wgde	547	18	,	,	,
cord-336510-qzm9wgde	547	19	and	and	CC
cord-336510-qzm9wgde	547	20	this	this	DT
cord-336510-qzm9wgde	547	21	enhanced	enhance	VBN
cord-336510-qzm9wgde	547	22	viral	viral	JJ
cord-336510-qzm9wgde	547	23	replication	replication	NN
cord-336510-qzm9wgde	547	24	was	be	VBD
cord-336510-qzm9wgde	547	25	most	most	RBS
cord-336510-qzm9wgde	547	26	prominent	prominent	JJ
cord-336510-qzm9wgde	547	27	during	during	IN
cord-336510-qzm9wgde	547	28	the	the	DT
cord-336510-qzm9wgde	547	29	first	first	JJ
cord-336510-qzm9wgde	547	30	24	24	CD
cord-336510-qzm9wgde	547	31	hours	hour	NNS
cord-336510-qzm9wgde	547	32	of	of	IN
cord-336510-qzm9wgde	547	33	infection	infection	NN
cord-336510-qzm9wgde	547	34	[	[	-LRB-
cord-336510-qzm9wgde	547	35	410	410	CD
cord-336510-qzm9wgde	547	36	]	]	-RRB-
cord-336510-qzm9wgde	547	37	.	.	.
cord-336510-qzm9wgde	548	1	In	in	IN
cord-336510-qzm9wgde	548	2	iNOS	inos	CD
cord-336510-qzm9wgde	548	3	-	-	HYPH
cord-336510-qzm9wgde	548	4	KO	KO	NNP
cord-336510-qzm9wgde	548	5	mice	mouse	NNS
cord-336510-qzm9wgde	548	6	,	,	,
cord-336510-qzm9wgde	548	7	the	the	DT
cord-336510-qzm9wgde	548	8	herpes	herpes	NN
cord-336510-qzm9wgde	548	9	virus	virus	NN
cord-336510-qzm9wgde	548	10	MCMV	MCMV	NNP
cord-336510-qzm9wgde	548	11	replicates	replicate	VBZ
cord-336510-qzm9wgde	548	12	to	to	IN
cord-336510-qzm9wgde	548	13	higher	high	JJR
cord-336510-qzm9wgde	548	14	titres	titre	NNS
cord-336510-qzm9wgde	548	15	in	in	IN
cord-336510-qzm9wgde	548	16	various	various	JJ
cord-336510-qzm9wgde	548	17	organs	organ	NNS
cord-336510-qzm9wgde	548	18	and	and	CC
cord-336510-qzm9wgde	548	19	in	in	IN
cord-336510-qzm9wgde	548	20	macrophages	macrophage	NNS
cord-336510-qzm9wgde	548	21	,	,	,
cord-336510-qzm9wgde	548	22	and	and	CC
cord-336510-qzm9wgde	548	23	this	this	DT
cord-336510-qzm9wgde	548	24	results	result	NNS
cord-336510-qzm9wgde	548	25	in	in	IN
cord-336510-qzm9wgde	548	26	impaired	impaired	JJ
cord-336510-qzm9wgde	548	27	survival	survival	NN
cord-336510-qzm9wgde	548	28	of	of	IN
cord-336510-qzm9wgde	548	29	the	the	DT
cord-336510-qzm9wgde	548	30	animals	animal	NNS
cord-336510-qzm9wgde	548	31	[	[	-LRB-
cord-336510-qzm9wgde	548	32	424	424	CD
cord-336510-qzm9wgde	548	33	]	]	-RRB-
cord-336510-qzm9wgde	548	34	.	.	.
cord-336510-qzm9wgde	549	1	Weanling	weanle	VBG
cord-336510-qzm9wgde	549	2	mice	mouse	NNS
cord-336510-qzm9wgde	549	3	with	with	IN
cord-336510-qzm9wgde	549	4	a	a	DT
cord-336510-qzm9wgde	549	5	targeted	target	VBN
cord-336510-qzm9wgde	549	6	disruption	disruption	NN
cord-336510-qzm9wgde	549	7	of	of	IN
cord-336510-qzm9wgde	549	8	the	the	DT
cord-336510-qzm9wgde	549	9	iNOS	inos	JJ
cord-336510-qzm9wgde	549	10	gene	gene	NN
cord-336510-qzm9wgde	549	11	showed	show	VBD
cord-336510-qzm9wgde	549	12	increased	increase	VBN
cord-336510-qzm9wgde	549	13	HSV	HSV	NNP
cord-336510-qzm9wgde	549	14	replication	replication	NN
cord-336510-qzm9wgde	549	15	,	,	,
cord-336510-qzm9wgde	549	16	but	but	CC
cord-336510-qzm9wgde	549	17	apparently	apparently	RB
cord-336510-qzm9wgde	549	18	without	without	IN
cord-336510-qzm9wgde	549	19	differences	difference	NNS
cord-336510-qzm9wgde	549	20	in	in	IN
cord-336510-qzm9wgde	549	21	HSV	HSV	NNP
cord-336510-qzm9wgde	549	22	titres	titre	NNS
cord-336510-qzm9wgde	549	23	during	during	IN
cord-336510-qzm9wgde	549	24	the	the	DT
cord-336510-qzm9wgde	549	25	first	first	JJ
cord-336510-qzm9wgde	549	26	days	day	NNS
cord-336510-qzm9wgde	549	27	of	of	IN
cord-336510-qzm9wgde	549	28	infection	infection	NN
cord-336510-qzm9wgde	549	29	[	[	-LRB-
cord-336510-qzm9wgde	549	30	425	425	CD
cord-336510-qzm9wgde	549	31	]	]	-RRB-
cord-336510-qzm9wgde	549	32	,	,	,
cord-336510-qzm9wgde	549	33	and	and	CC
cord-336510-qzm9wgde	549	34	in	in	IN
cord-336510-qzm9wgde	549	35	adult	adult	NN
cord-336510-qzm9wgde	549	36	KO	KO	NNP
cord-336510-qzm9wgde	549	37	mice	mouse	NNS
cord-336510-qzm9wgde	549	38	,	,	,
cord-336510-qzm9wgde	549	39	we	-PRON-	PRP
cord-336510-qzm9wgde	549	40	could	could	MD
cord-336510-qzm9wgde	549	41	not	not	RB
cord-336510-qzm9wgde	549	42	detect	detect	VB
cord-336510-qzm9wgde	549	43	any	any	DT
cord-336510-qzm9wgde	549	44	significant	significant	JJ
cord-336510-qzm9wgde	549	45	effect	effect	NN
cord-336510-qzm9wgde	549	46	of	of	IN
cord-336510-qzm9wgde	549	47	NO	no	NN
cord-336510-qzm9wgde	549	48	during	during	IN
cord-336510-qzm9wgde	549	49	the	the	DT
cord-336510-qzm9wgde	549	50	early	early	JJ
cord-336510-qzm9wgde	549	51	days	day	NNS
cord-336510-qzm9wgde	549	52	of	of	IN
cord-336510-qzm9wgde	549	53	a	a	DT
cord-336510-qzm9wgde	549	54	generalised	generalised	JJ
cord-336510-qzm9wgde	549	55	HSV	HSV	NNP
cord-336510-qzm9wgde	549	56	infection	infection	NN
cord-336510-qzm9wgde	549	57	(	(	-LRB-
cord-336510-qzm9wgde	549	58	Ellermann	Ellermann	NNP
cord-336510-qzm9wgde	549	59	-	-	HYPH
cord-336510-qzm9wgde	549	60	Eriksen	Eriksen	NNP
cord-336510-qzm9wgde	549	61	,	,	,
cord-336510-qzm9wgde	549	62	unpublished	unpublished	JJ
cord-336510-qzm9wgde	549	63	results	result	NNS
cord-336510-qzm9wgde	549	64	)	)	-RRB-
cord-336510-qzm9wgde	549	65	.	.	.
cord-336510-qzm9wgde	550	1	Probably	probably	RB
cord-336510-qzm9wgde	550	2	,	,	,
cord-336510-qzm9wgde	550	3	these	these	DT
cord-336510-qzm9wgde	550	4	in	in	IN
cord-336510-qzm9wgde	550	5	vivo	vivo	NN
cord-336510-qzm9wgde	550	6	results	result	NNS
cord-336510-qzm9wgde	550	7	are	be	VBP
cord-336510-qzm9wgde	550	8	due	due	JJ
cord-336510-qzm9wgde	550	9	to	to	IN
cord-336510-qzm9wgde	550	10	redundancy	redundancy	NN
cord-336510-qzm9wgde	550	11	of	of	IN
cord-336510-qzm9wgde	550	12	the	the	DT
cord-336510-qzm9wgde	550	13	antiviral	antiviral	JJ
cord-336510-qzm9wgde	550	14	system	system	NN
cord-336510-qzm9wgde	550	15	.	.	.
cord-336510-qzm9wgde	551	1	[	[	-LRB-
cord-336510-qzm9wgde	551	2	426	426	CD
cord-336510-qzm9wgde	551	3	]	]	-RRB-
cord-336510-qzm9wgde	551	4	.	.	.
cord-336510-qzm9wgde	552	1	The	the	DT
cord-336510-qzm9wgde	552	2	final	final	JJ
cord-336510-qzm9wgde	552	3	effects	effect	NNS
cord-336510-qzm9wgde	552	4	of	of	IN
cord-336510-qzm9wgde	552	5	NO	no	NN
cord-336510-qzm9wgde	552	6	on	on	IN
cord-336510-qzm9wgde	552	7	HSV	HSV	NNP
cord-336510-qzm9wgde	552	8	infections	infection	NNS
cord-336510-qzm9wgde	552	9	therefore	therefore	RB
cord-336510-qzm9wgde	552	10	appear	appear	VBP
cord-336510-qzm9wgde	552	11	to	to	TO
cord-336510-qzm9wgde	552	12	be	be	VB
cord-336510-qzm9wgde	552	13	balanced	balance	VBN
cord-336510-qzm9wgde	552	14	between	between	IN
cord-336510-qzm9wgde	552	15	antiviral	antiviral	JJ
cord-336510-qzm9wgde	552	16	versus	versus	IN
cord-336510-qzm9wgde	552	17	toxic	toxic	JJ
cord-336510-qzm9wgde	552	18	effects	effect	NNS
cord-336510-qzm9wgde	552	19	,	,	,
cord-336510-qzm9wgde	552	20	and	and	CC
cord-336510-qzm9wgde	552	21	the	the	DT
cord-336510-qzm9wgde	552	22	final	final	JJ
cord-336510-qzm9wgde	552	23	outcome	outcome	NN
cord-336510-qzm9wgde	552	24	seems	seem	VBZ
cord-336510-qzm9wgde	552	25	to	to	TO
cord-336510-qzm9wgde	552	26	depend	depend	VB
cord-336510-qzm9wgde	552	27	on	on	IN
cord-336510-qzm9wgde	552	28	the	the	DT
cord-336510-qzm9wgde	552	29	timing	timing	NN
cord-336510-qzm9wgde	552	30	,	,	,
cord-336510-qzm9wgde	552	31	infectious	infectious	JJ
cord-336510-qzm9wgde	552	32	dose	dose	NN
cord-336510-qzm9wgde	552	33	,	,	,
cord-336510-qzm9wgde	552	34	and	and	CC
cord-336510-qzm9wgde	552	35	tissues	tissue	NNS
cord-336510-qzm9wgde	552	36	involved	involve	VBN
cord-336510-qzm9wgde	552	37	.	.	.
cord-336510-qzm9wgde	553	1	Thus	thus	RB
cord-336510-qzm9wgde	553	2	NO	no	DT
cord-336510-qzm9wgde	553	3	production	production	NN
cord-336510-qzm9wgde	553	4	in	in	IN
cord-336510-qzm9wgde	553	5	the	the	DT
cord-336510-qzm9wgde	553	6	early	early	JJ
cord-336510-qzm9wgde	553	7	phases	phase	NNS
cord-336510-qzm9wgde	553	8	of	of	IN
cord-336510-qzm9wgde	553	9	HSV	HSV	NNP
cord-336510-qzm9wgde	553	10	infection	infection	NN
cord-336510-qzm9wgde	553	11	is	be	VBZ
cord-336510-qzm9wgde	553	12	one	one	CD
cord-336510-qzm9wgde	553	13	of	of	IN
cord-336510-qzm9wgde	553	14	the	the	DT
cord-336510-qzm9wgde	553	15	effector	effector	NN
cord-336510-qzm9wgde	553	16	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	553	17	of	of	IN
cord-336510-qzm9wgde	553	18	the	the	DT
cord-336510-qzm9wgde	553	19	innate	innate	JJ
cord-336510-qzm9wgde	553	20	immune	immune	JJ
cord-336510-qzm9wgde	553	21	response	response	NN
cord-336510-qzm9wgde	553	22	inhibiting	inhibit	VBG
cord-336510-qzm9wgde	553	23	HSV	HSV	NNP
cord-336510-qzm9wgde	553	24	replication	replication	NN
cord-336510-qzm9wgde	553	25	,	,	,
cord-336510-qzm9wgde	553	26	but	but	CC
cord-336510-qzm9wgde	553	27	when	when	WRB
cord-336510-qzm9wgde	553	28	overproduced	overproduce	VBN
cord-336510-qzm9wgde	553	29	,	,	,
cord-336510-qzm9wgde	553	30	NO	no	UH
cord-336510-qzm9wgde	553	31	might	may	MD
cord-336510-qzm9wgde	553	32	itself	-PRON-	PRP
cord-336510-qzm9wgde	553	33	result	result	VB
cord-336510-qzm9wgde	553	34	in	in	IN
cord-336510-qzm9wgde	553	35	pathology	pathology	NN
cord-336510-qzm9wgde	553	36	,	,	,
cord-336510-qzm9wgde	553	37	as	as	IN
cord-336510-qzm9wgde	553	38	discussed	discuss	VBN
cord-336510-qzm9wgde	553	39	in	in	IN
cord-336510-qzm9wgde	553	40	the	the	DT
cord-336510-qzm9wgde	553	41	following	following	JJ
cord-336510-qzm9wgde	553	42	section	section	NN
cord-336510-qzm9wgde	553	43	.	.	.
cord-336510-qzm9wgde	554	1	As	as	IN
cord-336510-qzm9wgde	554	2	outlined	outline	VBN
cord-336510-qzm9wgde	554	3	above	above	RB
cord-336510-qzm9wgde	554	4	,	,	,
cord-336510-qzm9wgde	554	5	positive	positive	JJ
cord-336510-qzm9wgde	554	6	feed	feed	NN
cord-336510-qzm9wgde	554	7	-	-	HYPH
cord-336510-qzm9wgde	554	8	back	back	NN
cord-336510-qzm9wgde	554	9	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	554	10	exist	exist	VBP
cord-336510-qzm9wgde	554	11	at	at	IN
cord-336510-qzm9wgde	554	12	the	the	DT
cord-336510-qzm9wgde	554	13	afferent	afferent	JJ
cord-336510-qzm9wgde	554	14	side	side	NN
cord-336510-qzm9wgde	554	15	of	of	IN
cord-336510-qzm9wgde	554	16	the	the	DT
cord-336510-qzm9wgde	554	17	early	early	JJ
cord-336510-qzm9wgde	554	18	cytokine	cytokine	NN
cord-336510-qzm9wgde	554	19	response	response	NN
cord-336510-qzm9wgde	554	20	,	,	,
cord-336510-qzm9wgde	554	21	involving	involve	VBG
cord-336510-qzm9wgde	554	22	especially	especially	RB
cord-336510-qzm9wgde	554	23	the	the	DT
cord-336510-qzm9wgde	554	24	production	production	NN
cord-336510-qzm9wgde	554	25	of	of	IN
cord-336510-qzm9wgde	554	26	IFN	IFN	NNP
cord-336510-qzm9wgde	554	27	-	-	HYPH
cord-336510-qzm9wgde	554	28	γ	γ	NNP
cord-336510-qzm9wgde	554	29	,	,	,
cord-336510-qzm9wgde	554	30	IL-12	IL-12	NNP
cord-336510-qzm9wgde	554	31	,	,	,
cord-336510-qzm9wgde	554	32	IFN	IFN	NNP
cord-336510-qzm9wgde	554	33	-	-	HYPH
cord-336510-qzm9wgde	554	34	α	α	NNP
cord-336510-qzm9wgde	554	35	/	/	SYM
cord-336510-qzm9wgde	554	36	β	β	NN
cord-336510-qzm9wgde	554	37	and	and	CC
cord-336510-qzm9wgde	554	38	TNF	TNF	NNP
cord-336510-qzm9wgde	554	39	,	,	,
cord-336510-qzm9wgde	554	40	and	and	CC
cord-336510-qzm9wgde	554	41	synergisms	synergism	NNS
cord-336510-qzm9wgde	554	42	at	at	IN
cord-336510-qzm9wgde	554	43	the	the	DT
cord-336510-qzm9wgde	554	44	efferent	efferent	JJ
cord-336510-qzm9wgde	554	45	side	side	NN
cord-336510-qzm9wgde	554	46	,	,	,
cord-336510-qzm9wgde	554	47	resulting	result	VBG
cord-336510-qzm9wgde	554	48	in	in	IN
cord-336510-qzm9wgde	554	49	highoutput	highoutput	NN
cord-336510-qzm9wgde	554	50	NO	no	DT
cord-336510-qzm9wgde	554	51	production	production	NN
cord-336510-qzm9wgde	554	52	.	.	.
cord-336510-qzm9wgde	555	1	As	as	IN
cord-336510-qzm9wgde	555	2	a	a	DT
cord-336510-qzm9wgde	555	3	result	result	NN
cord-336510-qzm9wgde	555	4	of	of	IN
cord-336510-qzm9wgde	555	5	coordinated	coordinated	JJ
cord-336510-qzm9wgde	555	6	induction	induction	NN
cord-336510-qzm9wgde	555	7	of	of	IN
cord-336510-qzm9wgde	555	8	the	the	DT
cord-336510-qzm9wgde	555	9	iNOS	inos	JJ
cord-336510-qzm9wgde	555	10	gene	gene	NN
cord-336510-qzm9wgde	555	11	by	by	IN
cord-336510-qzm9wgde	555	12	several	several	JJ
cord-336510-qzm9wgde	555	13	transcription	transcription	NN
cord-336510-qzm9wgde	555	14	factors	factor	NNS
cord-336510-qzm9wgde	555	15	,	,	,
cord-336510-qzm9wgde	555	16	activated	activate	VBN
cord-336510-qzm9wgde	555	17	by	by	IN
cord-336510-qzm9wgde	555	18	especially	especially	RB
cord-336510-qzm9wgde	555	19	IFN	IFN	NNP
cord-336510-qzm9wgde	555	20	-	-	HYPH
cord-336510-qzm9wgde	555	21	γ	γ	NNP
cord-336510-qzm9wgde	555	22	and	and	CC
cord-336510-qzm9wgde	555	23	TNF	TNF	NNP
cord-336510-qzm9wgde	555	24	,	,	,
cord-336510-qzm9wgde	555	25	a	a	DT
cord-336510-qzm9wgde	555	26	potent	potent	JJ
cord-336510-qzm9wgde	555	27	early	early	JJ
cord-336510-qzm9wgde	555	28	antiviral	antiviral	JJ
cord-336510-qzm9wgde	555	29	system	system	NN
cord-336510-qzm9wgde	555	30	is	be	VBZ
cord-336510-qzm9wgde	555	31	activated	activate	VBN
cord-336510-qzm9wgde	555	32	.	.	.
cord-336510-qzm9wgde	556	1	However	however	RB
cord-336510-qzm9wgde	556	2	,	,	,
cord-336510-qzm9wgde	556	3	NO	no	DT
cord-336510-qzm9wgde	556	4	causes	cause	VBZ
cord-336510-qzm9wgde	556	5	damage	damage	NN
cord-336510-qzm9wgde	556	6	to	to	IN
cord-336510-qzm9wgde	556	7	DNA	DNA	NNP
cord-336510-qzm9wgde	556	8	,	,	,
cord-336510-qzm9wgde	556	9	proteins	protein	NNS
cord-336510-qzm9wgde	556	10	and	and	CC
cord-336510-qzm9wgde	556	11	lipids	lipid	NNS
cord-336510-qzm9wgde	556	12	in	in	IN
cord-336510-qzm9wgde	556	13	cells	cell	NNS
cord-336510-qzm9wgde	556	14	and	and	CC
cord-336510-qzm9wgde	556	15	tissues	tissue	NNS
cord-336510-qzm9wgde	556	16	and	and	CC
cord-336510-qzm9wgde	556	17	could	could	MD
cord-336510-qzm9wgde	556	18	thus	thus	RB
cord-336510-qzm9wgde	556	19	be	be	VB
cord-336510-qzm9wgde	556	20	deleterious	deleterious	JJ
cord-336510-qzm9wgde	556	21	for	for	IN
cord-336510-qzm9wgde	556	22	the	the	DT
cord-336510-qzm9wgde	556	23	host	host	NN
cord-336510-qzm9wgde	556	24	[	[	-LRB-
cord-336510-qzm9wgde	556	25	427	427	CD
cord-336510-qzm9wgde	556	26	]	]	-RRB-
cord-336510-qzm9wgde	556	27	[	[	-LRB-
cord-336510-qzm9wgde	556	28	428	428	CD
cord-336510-qzm9wgde	556	29	]	]	-RRB-
cord-336510-qzm9wgde	556	30	[	[	-LRB-
cord-336510-qzm9wgde	556	31	429	429	CD
cord-336510-qzm9wgde	556	32	]	]	-RRB-
cord-336510-qzm9wgde	556	33	[	[	-LRB-
cord-336510-qzm9wgde	556	34	430	430	CD
cord-336510-qzm9wgde	556	35	]	]	-RRB-
cord-336510-qzm9wgde	556	36	.	.	.
cord-336510-qzm9wgde	557	1	A	a	DT
cord-336510-qzm9wgde	557	2	study	study	NN
cord-336510-qzm9wgde	557	3	in	in	IN
cord-336510-qzm9wgde	557	4	KO	KO	NNP
cord-336510-qzm9wgde	557	5	-	-	HYPH
cord-336510-qzm9wgde	557	6	mice	mice	NN
cord-336510-qzm9wgde	557	7	indicates	indicate	VBZ
cord-336510-qzm9wgde	557	8	that	that	IN
cord-336510-qzm9wgde	557	9	NO	no	DT
cord-336510-qzm9wgde	557	10	can	can	MD
cord-336510-qzm9wgde	557	11	be	be	VB
cord-336510-qzm9wgde	557	12	responsible	responsible	JJ
cord-336510-qzm9wgde	557	13	for	for	IN
cord-336510-qzm9wgde	557	14	inflammation	inflammation	NN
cord-336510-qzm9wgde	557	15	and	and	CC
cord-336510-qzm9wgde	557	16	life	life	NN
cord-336510-qzm9wgde	557	17	-	-	HYPH
cord-336510-qzm9wgde	557	18	threatening	threaten	VBG
cord-336510-qzm9wgde	557	19	symptoms	symptom	NNS
cord-336510-qzm9wgde	557	20	to	to	IN
cord-336510-qzm9wgde	557	21	HSV	HSV	NNP
cord-336510-qzm9wgde	557	22	infection	infection	NN
cord-336510-qzm9wgde	557	23	of	of	IN
cord-336510-qzm9wgde	557	24	the	the	DT
cord-336510-qzm9wgde	557	25	lungs	lung	NNS
cord-336510-qzm9wgde	557	26	[	[	-LRB-
cord-336510-qzm9wgde	557	27	135	135	CD
cord-336510-qzm9wgde	557	28	]	]	-RRB-
cord-336510-qzm9wgde	557	29	.	.	.
cord-336510-qzm9wgde	558	1	This	this	DT
cord-336510-qzm9wgde	558	2	effect	effect	NN
cord-336510-qzm9wgde	558	3	of	of	IN
cord-336510-qzm9wgde	558	4	NO	no	DT
cord-336510-qzm9wgde	558	5	on	on	IN
cord-336510-qzm9wgde	558	6	pulmonary	pulmonary	JJ
cord-336510-qzm9wgde	558	7	symptoms	symptom	NNS
cord-336510-qzm9wgde	558	8	is	be	VBZ
cord-336510-qzm9wgde	558	9	also	also	RB
cord-336510-qzm9wgde	558	10	observed	observe	VBN
cord-336510-qzm9wgde	558	11	in	in	IN
cord-336510-qzm9wgde	558	12	influenza	influenza	NN
cord-336510-qzm9wgde	558	13	virus	virus	NN
cord-336510-qzm9wgde	558	14	infections	infection	NNS
cord-336510-qzm9wgde	558	15	[	[	-LRB-
cord-336510-qzm9wgde	558	16	431	431	CD
cord-336510-qzm9wgde	558	17	]	]	-RRB-
cord-336510-qzm9wgde	558	18	,	,	,
cord-336510-qzm9wgde	558	19	although	although	IN
cord-336510-qzm9wgde	558	20	NO	no	DT
cord-336510-qzm9wgde	558	21	inhibits	inhibit	VBZ
cord-336510-qzm9wgde	558	22	replication	replication	NN
cord-336510-qzm9wgde	558	23	of	of	IN
cord-336510-qzm9wgde	558	24	both	both	DT
cord-336510-qzm9wgde	558	25	influenza	influenza	NN
cord-336510-qzm9wgde	558	26	virus	virus	NN
cord-336510-qzm9wgde	558	27	and	and	CC
cord-336510-qzm9wgde	558	28	severe	severe	JJ
cord-336510-qzm9wgde	558	29	acute	acute	JJ
cord-336510-qzm9wgde	558	30	respiratory	respiratory	JJ
cord-336510-qzm9wgde	558	31	syndrome	syndrome	NN
cord-336510-qzm9wgde	558	32	coronavirus	coronavirus	NN
cord-336510-qzm9wgde	558	33	[	[	-LRB-
cord-336510-qzm9wgde	558	34	432	432	CD
cord-336510-qzm9wgde	558	35	,	,	,
cord-336510-qzm9wgde	558	36	433	433	CD
cord-336510-qzm9wgde	558	37	]	]	-RRB-
cord-336510-qzm9wgde	558	38	.	.	.
cord-336510-qzm9wgde	559	1	Consequently	consequently	RB
cord-336510-qzm9wgde	559	2	,	,	,
cord-336510-qzm9wgde	559	3	when	when	WRB
cord-336510-qzm9wgde	559	4	this	this	DT
cord-336510-qzm9wgde	559	5	system	system	NN
cord-336510-qzm9wgde	559	6	is	be	VBZ
cord-336510-qzm9wgde	559	7	activated	activate	VBN
cord-336510-qzm9wgde	559	8	,	,	,
cord-336510-qzm9wgde	559	9	it	-PRON-	PRP
cord-336510-qzm9wgde	559	10	has	have	VBZ
cord-336510-qzm9wgde	559	11	to	to	TO
cord-336510-qzm9wgde	559	12	be	be	VB
cord-336510-qzm9wgde	559	13	controlled	control	VBN
cord-336510-qzm9wgde	559	14	and	and	CC
cord-336510-qzm9wgde	559	15	eventually	eventually	RB
cord-336510-qzm9wgde	559	16	closed	close	VBD
cord-336510-qzm9wgde	559	17	down	down	RP
cord-336510-qzm9wgde	559	18	,	,	,
cord-336510-qzm9wgde	559	19	as	as	IN
cord-336510-qzm9wgde	559	20	it	-PRON-	PRP
cord-336510-qzm9wgde	559	21	would	would	MD
cord-336510-qzm9wgde	559	22	otherwise	otherwise	RB
cord-336510-qzm9wgde	559	23	induce	induce	VB
cord-336510-qzm9wgde	559	24	unnecessary	unnecessary	JJ
cord-336510-qzm9wgde	559	25	harm	harm	NN
cord-336510-qzm9wgde	559	26	to	to	IN
cord-336510-qzm9wgde	559	27	the	the	DT
cord-336510-qzm9wgde	559	28	host	host	NN
cord-336510-qzm9wgde	559	29	.	.	.
cord-336510-qzm9wgde	560	1	Such	such	JJ
cord-336510-qzm9wgde	560	2	negative	negative	JJ
cord-336510-qzm9wgde	560	3	regulations	regulation	NNS
cord-336510-qzm9wgde	560	4	of	of	IN
cord-336510-qzm9wgde	560	5	the	the	DT
cord-336510-qzm9wgde	560	6	iNOS	inos	JJ
cord-336510-qzm9wgde	560	7	gene	gene	NN
cord-336510-qzm9wgde	560	8	induction	induction	NN
cord-336510-qzm9wgde	560	9	in	in	IN
cord-336510-qzm9wgde	560	10	IFN	IFN	NNP
cord-336510-qzm9wgde	560	11	-	-	HYPH
cord-336510-qzm9wgde	560	12	γ	γ	NNP
cord-336510-qzm9wgde	560	13	activated	activate	VBD
cord-336510-qzm9wgde	560	14	macrophages	macrophage	NNS
cord-336510-qzm9wgde	560	15	is	be	VBZ
cord-336510-qzm9wgde	560	16	conducted	conduct	VBN
cord-336510-qzm9wgde	560	17	by	by	IN
cord-336510-qzm9wgde	560	18	IL-4	IL-4	NNP
cord-336510-qzm9wgde	560	19	and	and	CC
cord-336510-qzm9wgde	560	20	IL-13	IL-13	NNP
cord-336510-qzm9wgde	560	21	[	[	-LRB-
cord-336510-qzm9wgde	560	22	272	272	CD
cord-336510-qzm9wgde	560	23	,	,	,
cord-336510-qzm9wgde	560	24	273	273	CD
cord-336510-qzm9wgde	560	25	,	,	,
cord-336510-qzm9wgde	560	26	434	434	CD
cord-336510-qzm9wgde	560	27	]	]	-RRB-
cord-336510-qzm9wgde	560	28	.	.	.
cord-336510-qzm9wgde	561	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	561	2	,	,	,
cord-336510-qzm9wgde	561	3	TGF	TGF	NNP
cord-336510-qzm9wgde	561	4	-	-	HYPH
cord-336510-qzm9wgde	561	5	β	β	NN
cord-336510-qzm9wgde	561	6	can	can	MD
cord-336510-qzm9wgde	561	7	exhibit	exhibit	VB
cord-336510-qzm9wgde	561	8	downregulation	downregulation	NN
cord-336510-qzm9wgde	561	9	of	of	IN
cord-336510-qzm9wgde	561	10	NO	no	DT
cord-336510-qzm9wgde	561	11	production	production	NN
cord-336510-qzm9wgde	561	12	through	through	IN
cord-336510-qzm9wgde	561	13	several	several	JJ
cord-336510-qzm9wgde	561	14	post	post	JJ
cord-336510-qzm9wgde	561	15	-	-	JJ
cord-336510-qzm9wgde	561	16	transcriptional	transcriptional	JJ
cord-336510-qzm9wgde	561	17	regulatory	regulatory	JJ
cord-336510-qzm9wgde	561	18	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	561	19	,	,	,
cord-336510-qzm9wgde	561	20	but	but	CC
cord-336510-qzm9wgde	561	21	the	the	DT
cord-336510-qzm9wgde	561	22	contribution	contribution	NN
cord-336510-qzm9wgde	561	23	of	of	IN
cord-336510-qzm9wgde	561	24	these	these	DT
cord-336510-qzm9wgde	561	25	pathways	pathway	NNS
cord-336510-qzm9wgde	561	26	have	have	VBP
cord-336510-qzm9wgde	561	27	not	not	RB
cord-336510-qzm9wgde	561	28	been	be	VBN
cord-336510-qzm9wgde	561	29	analysed	analyse	VBN
cord-336510-qzm9wgde	561	30	in	in	IN
cord-336510-qzm9wgde	561	31	HSV	HSV	NNP
cord-336510-qzm9wgde	561	32	infections	infection	NNS
cord-336510-qzm9wgde	561	33	[	[	-LRB-
cord-336510-qzm9wgde	561	34	435	435	CD
cord-336510-qzm9wgde	561	35	,	,	,
cord-336510-qzm9wgde	561	36	436	436	CD
cord-336510-qzm9wgde	561	37	]	]	-RRB-
cord-336510-qzm9wgde	561	38	.	.	.
cord-336510-qzm9wgde	562	1	IL-4	IL-4	NNP
cord-336510-qzm9wgde	562	2	production	production	NN
cord-336510-qzm9wgde	562	3	during	during	IN
cord-336510-qzm9wgde	562	4	HSV	HSV	NNP
cord-336510-qzm9wgde	562	5	infection	infection	NN
cord-336510-qzm9wgde	562	6	has	have	VBZ
cord-336510-qzm9wgde	562	7	in	in	IN
cord-336510-qzm9wgde	562	8	vaginal	vaginal	JJ
cord-336510-qzm9wgde	562	9	and	and	CC
cord-336510-qzm9wgde	562	10	CNS	cns	JJ
cord-336510-qzm9wgde	562	11	infections	infection	NNS
cord-336510-qzm9wgde	562	12	been	be	VBN
cord-336510-qzm9wgde	562	13	demonstrated	demonstrate	VBN
cord-336510-qzm9wgde	562	14	on	on	IN
cord-336510-qzm9wgde	562	15	day	day	NN
cord-336510-qzm9wgde	562	16	2	2	CD
cord-336510-qzm9wgde	562	17	of	of	IN
cord-336510-qzm9wgde	562	18	infection	infection	NN
cord-336510-qzm9wgde	562	19	and	and	CC
cord-336510-qzm9wgde	562	20	to	to	TO
cord-336510-qzm9wgde	562	21	increase	increase	VB
cord-336510-qzm9wgde	562	22	for	for	IN
cord-336510-qzm9wgde	562	23	the	the	DT
cord-336510-qzm9wgde	562	24	next	next	JJ
cord-336510-qzm9wgde	562	25	days	day	NNS
cord-336510-qzm9wgde	562	26	[	[	-LRB-
cord-336510-qzm9wgde	562	27	437	437	CD
cord-336510-qzm9wgde	562	28	,	,	,
cord-336510-qzm9wgde	562	29	438	438	CD
cord-336510-qzm9wgde	562	30	]	]	-RRB-
cord-336510-qzm9wgde	562	31	.	.	.
cord-336510-qzm9wgde	563	1	In	in	IN
cord-336510-qzm9wgde	563	2	peritoneal	peritoneal	JJ
cord-336510-qzm9wgde	563	3	cells	cell	NNS
cord-336510-qzm9wgde	563	4	from	from	IN
cord-336510-qzm9wgde	563	5	mice	mouse	NNS
cord-336510-qzm9wgde	563	6	infected	infect	VBD
cord-336510-qzm9wgde	563	7	i.p	i.p	NNP
cord-336510-qzm9wgde	563	8	.	.	.
cord-336510-qzm9wgde	563	9	pro	pro	JJ
cord-336510-qzm9wgde	563	10	-	-	JJ
cord-336510-qzm9wgde	563	11	duction	duction	NN
cord-336510-qzm9wgde	563	12	of	of	IN
cord-336510-qzm9wgde	563	13	IL-4	IL-4	NNP
cord-336510-qzm9wgde	563	14	could	could	MD
cord-336510-qzm9wgde	563	15	be	be	VB
cord-336510-qzm9wgde	563	16	detected	detect	VBN
cord-336510-qzm9wgde	563	17	at	at	IN
cord-336510-qzm9wgde	563	18	day	day	NN
cord-336510-qzm9wgde	563	19	5	5	CD
cord-336510-qzm9wgde	563	20	of	of	IN
cord-336510-qzm9wgde	563	21	infection	infection	NN
cord-336510-qzm9wgde	563	22	[	[	-LRB-
cord-336510-qzm9wgde	563	23	439	439	CD
cord-336510-qzm9wgde	563	24	]	]	-RRB-
cord-336510-qzm9wgde	563	25	.	.	.
cord-336510-qzm9wgde	564	1	At	at	IN
cord-336510-qzm9wgde	564	2	low	low	JJ
cord-336510-qzm9wgde	564	3	IFN	IFN	NNP
cord-336510-qzm9wgde	564	4	-	-	HYPH
cord-336510-qzm9wgde	564	5	γ	γ	NNP
cord-336510-qzm9wgde	564	6	concentrations	concentration	NNS
cord-336510-qzm9wgde	564	7	,	,	,
cord-336510-qzm9wgde	564	8	IL-4	IL-4	NNP
cord-336510-qzm9wgde	564	9	has	have	VBZ
cord-336510-qzm9wgde	564	10	been	be	VBN
cord-336510-qzm9wgde	564	11	shown	show	VBN
cord-336510-qzm9wgde	564	12	to	to	TO
cord-336510-qzm9wgde	564	13	inhibit	inhibit	VB
cord-336510-qzm9wgde	564	14	iNOS	inos	JJ
cord-336510-qzm9wgde	564	15	induction	induction	NN
cord-336510-qzm9wgde	564	16	through	through	IN
cord-336510-qzm9wgde	564	17	STAT6	stat6	NN
cord-336510-qzm9wgde	564	18	competition	competition	NN
cord-336510-qzm9wgde	564	19	with	with	IN
cord-336510-qzm9wgde	564	20	STAT1	stat1	NN
cord-336510-qzm9wgde	564	21	binding	bind	VBG
cord-336510-qzm9wgde	564	22	to	to	IN
cord-336510-qzm9wgde	564	23	the	the	DT
cord-336510-qzm9wgde	564	24	GAS	gas	NN
cord-336510-qzm9wgde	564	25	element	element	NN
cord-336510-qzm9wgde	564	26	of	of	IN
cord-336510-qzm9wgde	564	27	the	the	DT
cord-336510-qzm9wgde	564	28	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	564	29	promoter	promoter	NN
cord-336510-qzm9wgde	564	30	region	region	NN
cord-336510-qzm9wgde	564	31	.	.	.
cord-336510-qzm9wgde	565	1	This	this	DT
cord-336510-qzm9wgde	565	2	results	result	VBZ
cord-336510-qzm9wgde	565	3	in	in	IN
cord-336510-qzm9wgde	565	4	reduced	reduce	VBN
cord-336510-qzm9wgde	565	5	expression	expression	NN
cord-336510-qzm9wgde	565	6	of	of	IN
cord-336510-qzm9wgde	565	7	the	the	DT
cord-336510-qzm9wgde	565	8	transcription	transcription	NN
cord-336510-qzm9wgde	565	9	factor	factor	NN
cord-336510-qzm9wgde	565	10	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	565	11	,	,	,
cord-336510-qzm9wgde	565	12	which	which	WDT
cord-336510-qzm9wgde	565	13	is	be	VBZ
cord-336510-qzm9wgde	565	14	crucial	crucial	JJ
cord-336510-qzm9wgde	565	15	for	for	IN
cord-336510-qzm9wgde	565	16	induction	induction	NN
cord-336510-qzm9wgde	565	17	of	of	IN
cord-336510-qzm9wgde	565	18	iNOS	inos	JJ
cord-336510-qzm9wgde	565	19	[	[	-LRB-
cord-336510-qzm9wgde	565	20	440	440	CD
cord-336510-qzm9wgde	565	21	]	]	-RRB-
cord-336510-qzm9wgde	565	22	.	.	.
cord-336510-qzm9wgde	566	1	Generally	generally	RB
cord-336510-qzm9wgde	566	2	,	,	,
cord-336510-qzm9wgde	566	3	STAT6	STAT6	NNP
cord-336510-qzm9wgde	566	4	was	be	VBD
cord-336510-qzm9wgde	566	5	shown	show	VBN
cord-336510-qzm9wgde	566	6	to	to	TO
cord-336510-qzm9wgde	566	7	be	be	VB
cord-336510-qzm9wgde	566	8	a	a	DT
cord-336510-qzm9wgde	566	9	key	key	JJ
cord-336510-qzm9wgde	566	10	factor	factor	NN
cord-336510-qzm9wgde	566	11	in	in	IN
cord-336510-qzm9wgde	566	12	IL-4-and	IL-4-and	NNP
cord-336510-qzm9wgde	566	13	IL-13-induced	il-13-induced	CD
cord-336510-qzm9wgde	566	14	inhibition	inhibition	NN
cord-336510-qzm9wgde	566	15	of	of	IN
cord-336510-qzm9wgde	566	16	iNOS	inos	JJ
cord-336510-qzm9wgde	566	17	gene	gene	NN
cord-336510-qzm9wgde	566	18	transcription	transcription	NN
cord-336510-qzm9wgde	566	19	induced	induce	VBN
cord-336510-qzm9wgde	566	20	by	by	IN
cord-336510-qzm9wgde	566	21	IFN	IFN	NNP
cord-336510-qzm9wgde	566	22	-	-	HYPH
cord-336510-qzm9wgde	566	23	γ	γ	NNP
cord-336510-qzm9wgde	566	24	(	(	-LRB-
cord-336510-qzm9wgde	566	25	fig	fig	NN
cord-336510-qzm9wgde	566	26	.	.	.
cord-336510-qzm9wgde	566	27	5	5	LS
cord-336510-qzm9wgde	566	28	)	)	-RRB-
cord-336510-qzm9wgde	567	1	[	[	-LRB-
cord-336510-qzm9wgde	567	2	441	441	CD
cord-336510-qzm9wgde	567	3	]	]	-RRB-
cord-336510-qzm9wgde	567	4	.	.	.
cord-336510-qzm9wgde	568	1	At	at	IN
cord-336510-qzm9wgde	568	2	higher	high	JJR
cord-336510-qzm9wgde	568	3	IFN	IFN	NNP
cord-336510-qzm9wgde	568	4	-	-	HYPH
cord-336510-qzm9wgde	568	5	γ	γ	NNP
cord-336510-qzm9wgde	568	6	concentrations	concentration	NNS
cord-336510-qzm9wgde	568	7	,	,	,
cord-336510-qzm9wgde	568	8	activated	activate	VBN
cord-336510-qzm9wgde	568	9	STAT6	stat6	NN
cord-336510-qzm9wgde	568	10	is	be	VBZ
cord-336510-qzm9wgde	568	11	no	no	RB
cord-336510-qzm9wgde	568	12	longer	longer	RB
cord-336510-qzm9wgde	568	13	able	able	JJ
cord-336510-qzm9wgde	568	14	to	to	TO
cord-336510-qzm9wgde	568	15	compete	compete	VB
cord-336510-qzm9wgde	568	16	with	with	IN
cord-336510-qzm9wgde	568	17	the	the	DT
cord-336510-qzm9wgde	568	18	high	high	JJ
cord-336510-qzm9wgde	568	19	amounts	amount	NNS
cord-336510-qzm9wgde	568	20	of	of	IN
cord-336510-qzm9wgde	568	21	activated	activate	VBN
cord-336510-qzm9wgde	568	22	STAT1	stat1	NN
cord-336510-qzm9wgde	568	23	dimer	dimer	NN
cord-336510-qzm9wgde	568	24	[	[	-LRB-
cord-336510-qzm9wgde	568	25	440	440	CD
cord-336510-qzm9wgde	568	26	]	]	-RRB-
cord-336510-qzm9wgde	568	27	.	.	.
cord-336510-qzm9wgde	569	1	However	however	RB
cord-336510-qzm9wgde	569	2	,	,	,
cord-336510-qzm9wgde	569	3	in	in	IN
cord-336510-qzm9wgde	569	4	this	this	DT
cord-336510-qzm9wgde	569	5	situation	situation	NN
cord-336510-qzm9wgde	569	6	IL-4	IL-4	NNP
cord-336510-qzm9wgde	569	7	is	be	VBZ
cord-336510-qzm9wgde	569	8	still	still	RB
cord-336510-qzm9wgde	569	9	able	able	JJ
cord-336510-qzm9wgde	569	10	to	to	TO
cord-336510-qzm9wgde	569	11	inhibit	inhibit	VB
cord-336510-qzm9wgde	569	12	the	the	DT
cord-336510-qzm9wgde	569	13	production	production	NN
cord-336510-qzm9wgde	569	14	of	of	IN
cord-336510-qzm9wgde	569	15	NO	no	NN
cord-336510-qzm9wgde	569	16	from	from	IN
cord-336510-qzm9wgde	569	17	IFN	IFN	NNP
cord-336510-qzm9wgde	569	18	-	-	HYPH
cord-336510-qzm9wgde	569	19	γ	γ	NN
cord-336510-qzm9wgde	569	20	-	-	HYPH
cord-336510-qzm9wgde	569	21	stimulated	stimulate	VBN
cord-336510-qzm9wgde	569	22	macrophages	macrophage	NNS
cord-336510-qzm9wgde	569	23	[	[	-LRB-
cord-336510-qzm9wgde	569	24	272	272	CD
cord-336510-qzm9wgde	569	25	,	,	,
cord-336510-qzm9wgde	569	26	273	273	CD
cord-336510-qzm9wgde	569	27	,	,	,
cord-336510-qzm9wgde	569	28	434	434	CD
cord-336510-qzm9wgde	569	29	]	]	-RRB-
cord-336510-qzm9wgde	569	30	.	.	.
cord-336510-qzm9wgde	570	1	In	in	IN
cord-336510-qzm9wgde	570	2	the	the	DT
cord-336510-qzm9wgde	570	3	presence	presence	NN
cord-336510-qzm9wgde	570	4	of	of	IN
cord-336510-qzm9wgde	570	5	high	high	JJ
cord-336510-qzm9wgde	570	6	levels	level	NNS
cord-336510-qzm9wgde	570	7	of	of	IN
cord-336510-qzm9wgde	570	8	IFN	IFN	NNP
cord-336510-qzm9wgde	570	9	-	-	HYPH
cord-336510-qzm9wgde	570	10	γ	γ	NNP
cord-336510-qzm9wgde	570	11	,	,	,
cord-336510-qzm9wgde	570	12	IL-4	IL-4	NNP
cord-336510-qzm9wgde	570	13	is	be	VBZ
cord-336510-qzm9wgde	570	14	not	not	RB
cord-336510-qzm9wgde	570	15	able	able	JJ
cord-336510-qzm9wgde	570	16	to	to	TO
cord-336510-qzm9wgde	570	17	alter	alter	VB
cord-336510-qzm9wgde	570	18	the	the	DT
cord-336510-qzm9wgde	570	19	induction	induction	NN
cord-336510-qzm9wgde	570	20	of	of	IN
cord-336510-qzm9wgde	570	21	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	570	22	,	,	,
cord-336510-qzm9wgde	570	23	but	but	CC
cord-336510-qzm9wgde	570	24	the	the	DT
cord-336510-qzm9wgde	570	25	production	production	NN
cord-336510-qzm9wgde	570	26	of	of	IN
cord-336510-qzm9wgde	570	27	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	570	28	is	be	VBZ
cord-336510-qzm9wgde	570	29	increased	increase	VBN
cord-336510-qzm9wgde	570	30	[	[	-LRB-
cord-336510-qzm9wgde	570	31	434	434	CD
cord-336510-qzm9wgde	570	32	]	]	-RRB-
cord-336510-qzm9wgde	570	33	.	.	.
cord-336510-qzm9wgde	571	1	The	the	DT
cord-336510-qzm9wgde	571	2	human	human	JJ
cord-336510-qzm9wgde	571	3	promoter	promoter	NN
cord-336510-qzm9wgde	571	4	region	region	NN
cord-336510-qzm9wgde	571	5	of	of	IN
cord-336510-qzm9wgde	571	6	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	571	7	contains	contain	VBZ
cord-336510-qzm9wgde	571	8	a	a	DT
cord-336510-qzm9wgde	571	9	SBE	SBE	NNP
cord-336510-qzm9wgde	571	10	,	,	,
cord-336510-qzm9wgde	571	11	and	and	CC
cord-336510-qzm9wgde	571	12	the	the	DT
cord-336510-qzm9wgde	571	13	induction	induction	NN
cord-336510-qzm9wgde	571	14	of	of	IN
cord-336510-qzm9wgde	571	15	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	571	16	could	could	MD
cord-336510-qzm9wgde	571	17	thus	thus	RB
cord-336510-qzm9wgde	571	18	potentially	potentially	RB
cord-336510-qzm9wgde	571	19	be	be	VB
cord-336510-qzm9wgde	571	20	mediated	mediate	VBN
cord-336510-qzm9wgde	571	21	by	by	IN
cord-336510-qzm9wgde	571	22	STAT6	STAT6	NNS
cord-336510-qzm9wgde	571	23	binding	bind	VBG
cord-336510-qzm9wgde	571	24	to	to	IN
cord-336510-qzm9wgde	571	25	this	this	DT
cord-336510-qzm9wgde	571	26	element	element	NN
cord-336510-qzm9wgde	571	27	[	[	-LRB-
cord-336510-qzm9wgde	571	28	442	442	CD
cord-336510-qzm9wgde	571	29	]	]	-RRB-
cord-336510-qzm9wgde	571	30	.	.	.
cord-336510-qzm9wgde	572	1	This	this	DT
cord-336510-qzm9wgde	572	2	is	be	VBZ
cord-336510-qzm9wgde	572	3	in	in	IN
cord-336510-qzm9wgde	572	4	agreement	agreement	NN
cord-336510-qzm9wgde	572	5	with	with	IN
cord-336510-qzm9wgde	572	6	the	the	DT
cord-336510-qzm9wgde	572	7	fact	fact	NN
cord-336510-qzm9wgde	572	8	that	that	IN
cord-336510-qzm9wgde	572	9	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	572	10	is	be	VBZ
cord-336510-qzm9wgde	572	11	known	know	VBN
cord-336510-qzm9wgde	572	12	to	to	TO
cord-336510-qzm9wgde	572	13	compete	compete	VB
cord-336510-qzm9wgde	572	14	with	with	IN
cord-336510-qzm9wgde	572	15	the	the	DT
cord-336510-qzm9wgde	572	16	binding	binding	NN
cord-336510-qzm9wgde	572	17	of	of	IN
cord-336510-qzm9wgde	572	18	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	572	19	to	to	IN
cord-336510-qzm9wgde	572	20	ISRE	ISRE	NNP
cord-336510-qzm9wgde	572	21	sites	site	NNS
cord-336510-qzm9wgde	572	22	and	and	CC
cord-336510-qzm9wgde	572	23	to	to	TO
cord-336510-qzm9wgde	572	24	antagonize	antagonize	VB
cord-336510-qzm9wgde	572	25	the	the	DT
cord-336510-qzm9wgde	572	26	transactivating	transactivating	NN
cord-336510-qzm9wgde	572	27	activity	activity	NN
cord-336510-qzm9wgde	572	28	of	of	IN
cord-336510-qzm9wgde	572	29	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	572	30	in	in	IN
cord-336510-qzm9wgde	572	31	the	the	DT
cord-336510-qzm9wgde	572	32	regulation	regulation	NN
cord-336510-qzm9wgde	572	33	of	of	IN
cord-336510-qzm9wgde	572	34	other	other	JJ
cord-336510-qzm9wgde	572	35	IFNinduced	ifninduced	JJ
cord-336510-qzm9wgde	572	36	genes	gene	NNS
cord-336510-qzm9wgde	572	37	[	[	-LRB-
cord-336510-qzm9wgde	572	38	443	443	CD
cord-336510-qzm9wgde	572	39	]	]	-RRB-
cord-336510-qzm9wgde	572	40	[	[	-LRB-
cord-336510-qzm9wgde	572	41	444	444	CD
cord-336510-qzm9wgde	572	42	]	]	-RRB-
cord-336510-qzm9wgde	572	43	[	[	-LRB-
cord-336510-qzm9wgde	572	44	445	445	CD
cord-336510-qzm9wgde	572	45	]	]	-RRB-
cord-336510-qzm9wgde	572	46	.	.	.
cord-336510-qzm9wgde	573	1	Inhibition	inhibition	NN
cord-336510-qzm9wgde	573	2	of	of	IN
cord-336510-qzm9wgde	573	3	iNOS	inos	JJ
cord-336510-qzm9wgde	573	4	expression	expression	NN
cord-336510-qzm9wgde	573	5	by	by	IN
cord-336510-qzm9wgde	573	6	high	high	JJ
cord-336510-qzm9wgde	573	7	concentrations	concentration	NNS
cord-336510-qzm9wgde	573	8	of	of	IN
cord-336510-qzm9wgde	573	9	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	573	10	relative	relative	JJ
cord-336510-qzm9wgde	573	11	to	to	IN
cord-336510-qzm9wgde	573	12	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	573	13	has	have	VBZ
cord-336510-qzm9wgde	573	14	thus	thus	RB
cord-336510-qzm9wgde	573	15	been	be	VBN
cord-336510-qzm9wgde	573	16	proposed	propose	VBN
cord-336510-qzm9wgde	573	17	as	as	IN
cord-336510-qzm9wgde	573	18	a	a	DT
cord-336510-qzm9wgde	573	19	controlling	control	VBG
cord-336510-qzm9wgde	573	20	mechanism	mechanism	NN
cord-336510-qzm9wgde	573	21	in	in	IN
cord-336510-qzm9wgde	573	22	situations	situation	NNS
cord-336510-qzm9wgde	573	23	with	with	IN
cord-336510-qzm9wgde	573	24	high	high	JJ
cord-336510-qzm9wgde	573	25	levels	level	NNS
cord-336510-qzm9wgde	573	26	of	of	IN
cord-336510-qzm9wgde	573	27	IFN	IFN	NNP
cord-336510-qzm9wgde	573	28	-	-	HYPH
cord-336510-qzm9wgde	573	29	γ	γ	NNP
cord-336510-qzm9wgde	573	30	(	(	-LRB-
cord-336510-qzm9wgde	573	31	fig	fig	NN
cord-336510-qzm9wgde	573	32	.	.	.
cord-336510-qzm9wgde	573	33	5	5	LS
cord-336510-qzm9wgde	573	34	)	)	-RRB-
cord-336510-qzm9wgde	574	1	[	[	-LRB-
cord-336510-qzm9wgde	574	2	434	434	CD
cord-336510-qzm9wgde	574	3	]	]	-RRB-
cord-336510-qzm9wgde	574	4	.	.	.
cord-336510-qzm9wgde	575	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	575	2	,	,	,
cord-336510-qzm9wgde	575	3	another	another	DT
cord-336510-qzm9wgde	575	4	mechanism	mechanism	NN
cord-336510-qzm9wgde	575	5	could	could	MD
cord-336510-qzm9wgde	575	6	evolve	evolve	VB
cord-336510-qzm9wgde	575	7	from	from	IN
cord-336510-qzm9wgde	575	8	the	the	DT
cord-336510-qzm9wgde	575	9	observation	observation	NN
cord-336510-qzm9wgde	575	10	that	that	WDT
cord-336510-qzm9wgde	575	11	IL-4	IL-4	NNP
cord-336510-qzm9wgde	575	12	signalling	signalling	NN
cord-336510-qzm9wgde	575	13	can	can	MD
cord-336510-qzm9wgde	575	14	result	result	VB
cord-336510-qzm9wgde	575	15	in	in	IN
cord-336510-qzm9wgde	575	16	disruption	disruption	NN
cord-336510-qzm9wgde	575	17	of	of	IN
cord-336510-qzm9wgde	575	18	the	the	DT
cord-336510-qzm9wgde	575	19	complex	complex	JJ
cord-336510-qzm9wgde	575	20	formation	formation	NN
cord-336510-qzm9wgde	575	21	of	of	IN
cord-336510-qzm9wgde	575	22	ICSBP	ICSBP	NNP
cord-336510-qzm9wgde	575	23	and	and	CC
cord-336510-qzm9wgde	575	24	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	575	25	and	and	CC
cord-336510-qzm9wgde	575	26	thereby	thereby	RB
cord-336510-qzm9wgde	575	27	inhibit	inhibit	VB
cord-336510-qzm9wgde	575	28	iNOS	inos	JJ
cord-336510-qzm9wgde	575	29	induction	induction	NN
cord-336510-qzm9wgde	575	30	[	[	-LRB-
cord-336510-qzm9wgde	575	31	416	416	CD
cord-336510-qzm9wgde	575	32	]	]	-RRB-
cord-336510-qzm9wgde	575	33	.	.	.
cord-336510-qzm9wgde	576	1	Other	other	JJ
cord-336510-qzm9wgde	576	2	mediators	mediator	NNS
cord-336510-qzm9wgde	576	3	of	of	IN
cord-336510-qzm9wgde	576	4	IL-4-induced	il-4-induce	VBN
cord-336510-qzm9wgde	576	5	repression	repression	NN
cord-336510-qzm9wgde	576	6	of	of	IN
cord-336510-qzm9wgde	576	7	iNOS	inos	CD
cord-336510-qzm9wgde	576	8	induction	induction	NN
cord-336510-qzm9wgde	576	9	might	may	MD
cord-336510-qzm9wgde	576	10	exist	exist	VB
cord-336510-qzm9wgde	576	11	,	,	,
cord-336510-qzm9wgde	576	12	in	in	IN
cord-336510-qzm9wgde	576	13	that	that	IN
cord-336510-qzm9wgde	576	14	another	another	DT
cord-336510-qzm9wgde	576	15	DNAbinding	dnabinde	VBG
cord-336510-qzm9wgde	576	16	transcriptional	transcriptional	NN
cord-336510-qzm9wgde	576	17	repressor	repressor	NN
cord-336510-qzm9wgde	576	18	competing	compete	VBG
cord-336510-qzm9wgde	576	19	with	with	IN
cord-336510-qzm9wgde	576	20	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	576	21	has	have	VBZ
cord-336510-qzm9wgde	576	22	been	be	VBN
cord-336510-qzm9wgde	576	23	described	describe	VBN
cord-336510-qzm9wgde	576	24	[	[	-LRB-
cord-336510-qzm9wgde	576	25	446	446	CD
cord-336510-qzm9wgde	576	26	]	]	-RRB-
cord-336510-qzm9wgde	576	27	.	.	.
cord-336510-qzm9wgde	577	1	In	in	IN
cord-336510-qzm9wgde	577	2	IFN	IFN	NNP
cord-336510-qzm9wgde	577	3	-	-	HYPH
cord-336510-qzm9wgde	577	4	γ	γ	NNP
cord-336510-qzm9wgde	577	5	activated	activate	VBD
cord-336510-qzm9wgde	577	6	macrophages	macrophage	NNS
cord-336510-qzm9wgde	577	7	the	the	DT
cord-336510-qzm9wgde	577	8	IL-4-and	IL-4-and	NNP
cord-336510-qzm9wgde	577	9	IL-13induced	IL-13induced	NNP
cord-336510-qzm9wgde	577	10	inhibition	inhibition	NN
cord-336510-qzm9wgde	577	11	of	of	IN
cord-336510-qzm9wgde	577	12	iNOS	inos	JJ
cord-336510-qzm9wgde	577	13	induction	induction	NN
cord-336510-qzm9wgde	577	14	can	can	MD
cord-336510-qzm9wgde	577	15	thus	thus	RB
cord-336510-qzm9wgde	577	16	be	be	VB
cord-336510-qzm9wgde	577	17	overruled	overrule	VBN
cord-336510-qzm9wgde	577	18	by	by	IN
cord-336510-qzm9wgde	577	19	HSV	HSV	NNP
cord-336510-qzm9wgde	577	20	infection	infection	NN
cord-336510-qzm9wgde	577	21	,	,	,
cord-336510-qzm9wgde	577	22	leading	lead	VBG
cord-336510-qzm9wgde	577	23	to	to	IN
cord-336510-qzm9wgde	577	24	a	a	DT
cord-336510-qzm9wgde	577	25	sustained	sustained	JJ
cord-336510-qzm9wgde	577	26	NO	no	DT
cord-336510-qzm9wgde	577	27	production	production	NN
cord-336510-qzm9wgde	577	28	(	(	-LRB-
cord-336510-qzm9wgde	577	29	fig	fig	NN
cord-336510-qzm9wgde	577	30	.	.	.
cord-336510-qzm9wgde	577	31	4	4	LS
cord-336510-qzm9wgde	577	32	)	)	-RRB-
cord-336510-qzm9wgde	578	1	[	[	-LRB-
cord-336510-qzm9wgde	578	2	439	439	CD
cord-336510-qzm9wgde	578	3	,	,	,
cord-336510-qzm9wgde	578	4	447	447	CD
cord-336510-qzm9wgde	578	5	]	]	-RRB-
cord-336510-qzm9wgde	578	6	.	.	.
cord-336510-qzm9wgde	579	1	This	this	DT
cord-336510-qzm9wgde	579	2	effect	effect	NN
cord-336510-qzm9wgde	579	3	of	of	IN
cord-336510-qzm9wgde	579	4	HSV	HSV	NNP
cord-336510-qzm9wgde	579	5	infection	infection	NN
cord-336510-qzm9wgde	579	6	is	be	VBZ
cord-336510-qzm9wgde	579	7	mediated	mediate	VBN
cord-336510-qzm9wgde	579	8	through	through	IN
cord-336510-qzm9wgde	579	9	TNF	TNF	NNP
cord-336510-qzm9wgde	579	10	production	production	NN
cord-336510-qzm9wgde	579	11	and	and	CC
cord-336510-qzm9wgde	579	12	NF	nf	NN
cord-336510-qzm9wgde	579	13	-	-	HYPH
cord-336510-qzm9wgde	579	14	κB	κb	CD
cord-336510-qzm9wgde	579	15	activation	activation	NN
cord-336510-qzm9wgde	579	16	[	[	-LRB-
cord-336510-qzm9wgde	579	17	439	439	CD
cord-336510-qzm9wgde	579	18	,	,	,
cord-336510-qzm9wgde	579	19	447	447	CD
cord-336510-qzm9wgde	579	20	]	]	-RRB-
cord-336510-qzm9wgde	579	21	.	.	.
cord-336510-qzm9wgde	580	1	However	however	RB
cord-336510-qzm9wgde	580	2	,	,	,
cord-336510-qzm9wgde	580	3	pre	pre	JJ
cord-336510-qzm9wgde	580	4	-	-	NN
cord-336510-qzm9wgde	580	5	treatment	treatment	NN
cord-336510-qzm9wgde	580	6	with	with	IN
cord-336510-qzm9wgde	580	7	IL-4	IL-4	NNP
cord-336510-qzm9wgde	580	8	has	have	VBZ
cord-336510-qzm9wgde	580	9	in	in	IN
cord-336510-qzm9wgde	580	10	a	a	DT
cord-336510-qzm9wgde	580	11	Theiler	Theiler	NNP
cord-336510-qzm9wgde	580	12	's	's	POS
cord-336510-qzm9wgde	580	13	murine	murine	JJ
cord-336510-qzm9wgde	580	14	encephalomyelitis	encephalomyelitis	NN
cord-336510-qzm9wgde	580	15	virus	virus	NN
cord-336510-qzm9wgde	580	16	model	model	NN
cord-336510-qzm9wgde	580	17	showed	show	VBD
cord-336510-qzm9wgde	580	18	inhibition	inhibition	NN
cord-336510-qzm9wgde	580	19	of	of	IN
cord-336510-qzm9wgde	580	20	NF	NF	NNP
cord-336510-qzm9wgde	580	21	-	-	HYPH
cord-336510-qzm9wgde	580	22	κB	κb	CD
cord-336510-qzm9wgde	580	23	activation	activation	NN
cord-336510-qzm9wgde	580	24	[	[	-LRB-
cord-336510-qzm9wgde	580	25	448	448	CD
cord-336510-qzm9wgde	580	26	]	]	-RRB-
cord-336510-qzm9wgde	580	27	.	.	.
cord-336510-qzm9wgde	581	1	In	in	IN
cord-336510-qzm9wgde	581	2	thioglycollateinduced	thioglycollateinduced	JJ
cord-336510-qzm9wgde	581	3	peritoneal	peritoneal	NN
cord-336510-qzm9wgde	581	4	cells	cell	NNS
cord-336510-qzm9wgde	581	5	,	,	,
cord-336510-qzm9wgde	581	6	LPS	LPS	NNP
cord-336510-qzm9wgde	581	7	and	and	CC
cord-336510-qzm9wgde	581	8	TNF	TNF	NNP
cord-336510-qzm9wgde	581	9	could	could	MD
cord-336510-qzm9wgde	581	10	only	only	RB
cord-336510-qzm9wgde	581	11	overcome	overcome	VB
cord-336510-qzm9wgde	581	12	the	the	DT
cord-336510-qzm9wgde	581	13	inhibiting	inhibit	VBG
cord-336510-qzm9wgde	581	14	effect	effect	NN
cord-336510-qzm9wgde	581	15	of	of	IN
cord-336510-qzm9wgde	581	16	IL-4	IL-4	NNP
cord-336510-qzm9wgde	581	17	in	in	IN
cord-336510-qzm9wgde	581	18	situations	situation	NNS
cord-336510-qzm9wgde	581	19	,	,	,
cord-336510-qzm9wgde	581	20	where	where	WRB
cord-336510-qzm9wgde	581	21	IL-4	IL-4	NNP
cord-336510-qzm9wgde	581	22	was	be	VBD
cord-336510-qzm9wgde	581	23	added	add	VBN
cord-336510-qzm9wgde	581	24	simultaneously	simultaneously	RB
cord-336510-qzm9wgde	581	25	or	or	CC
cord-336510-qzm9wgde	581	26	after	after	IN
cord-336510-qzm9wgde	581	27	the	the	DT
cord-336510-qzm9wgde	581	28	stimulators	stimulator	NNS
cord-336510-qzm9wgde	581	29	[	[	-LRB-
cord-336510-qzm9wgde	581	30	272	272	CD
cord-336510-qzm9wgde	581	31	]	]	-RRB-
cord-336510-qzm9wgde	581	32	,	,	,
cord-336510-qzm9wgde	581	33	a	a	DT
cord-336510-qzm9wgde	581	34	sequence	sequence	NN
cord-336510-qzm9wgde	581	35	of	of	IN
cord-336510-qzm9wgde	581	36	events	event	NNS
cord-336510-qzm9wgde	581	37	which	which	WDT
cord-336510-qzm9wgde	581	38	,	,	,
cord-336510-qzm9wgde	581	39	however	however	RB
cord-336510-qzm9wgde	581	40	,	,	,
cord-336510-qzm9wgde	581	41	is	be	VBZ
cord-336510-qzm9wgde	581	42	in	in	IN
cord-336510-qzm9wgde	581	43	agreement	agreement	NN
cord-336510-qzm9wgde	581	44	with	with	IN
cord-336510-qzm9wgde	581	45	the	the	DT
cord-336510-qzm9wgde	581	46	sequence	sequence	NN
cord-336510-qzm9wgde	581	47	of	of	IN
cord-336510-qzm9wgde	581	48	cytokine	cytokine	JJ
cord-336510-qzm9wgde	581	49	production	production	NN
cord-336510-qzm9wgde	581	50	in	in	IN
cord-336510-qzm9wgde	581	51	HSV	HSV	NNP
cord-336510-qzm9wgde	581	52	infections	infection	NNS
cord-336510-qzm9wgde	581	53	.	.	.
cord-336510-qzm9wgde	582	1	When	when	WRB
cord-336510-qzm9wgde	582	2	activated	activate	VBN
cord-336510-qzm9wgde	582	3	,	,	,
cord-336510-qzm9wgde	582	4	the	the	DT
cord-336510-qzm9wgde	582	5	NF	nf	NN
cord-336510-qzm9wgde	582	6	-	-	HYPH
cord-336510-qzm9wgde	582	7	κB	κB	NNP
cord-336510-qzm9wgde	582	8	p65	p65	NN
cord-336510-qzm9wgde	582	9	physically	physically	RB
cord-336510-qzm9wgde	582	10	interacts	interact	VBZ
cord-336510-qzm9wgde	582	11	with	with	IN
cord-336510-qzm9wgde	582	12	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	582	13	and	and	CC
cord-336510-qzm9wgde	582	14	trans	trans	NNP
cord-336510-qzm9wgde	582	15	-	-	JJ
cord-336510-qzm9wgde	582	16	activate	activate	VB
cord-336510-qzm9wgde	582	17	iNOS	inos	JJ
cord-336510-qzm9wgde	582	18	transcription	transcription	NN
cord-336510-qzm9wgde	582	19	in	in	IN
cord-336510-qzm9wgde	582	20	HSVinfected	HSVinfected	NNP
cord-336510-qzm9wgde	582	21	and	and	CC
cord-336510-qzm9wgde	582	22	TNF	TNF	NNP
cord-336510-qzm9wgde	582	23	-	-	HYPH
cord-336510-qzm9wgde	582	24	treated	treat	VBN
cord-336510-qzm9wgde	582	25	cells	cell	NNS
cord-336510-qzm9wgde	582	26	[	[	-LRB-
cord-336510-qzm9wgde	582	27	411	411	CD
cord-336510-qzm9wgde	582	28	,	,	,
cord-336510-qzm9wgde	582	29	449	449	CD
cord-336510-qzm9wgde	582	30	]	]	-RRB-
cord-336510-qzm9wgde	582	31	.	.	.
cord-336510-qzm9wgde	583	1	It	-PRON-	PRP
cord-336510-qzm9wgde	583	2	is	be	VBZ
cord-336510-qzm9wgde	583	3	thus	thus	RB
cord-336510-qzm9wgde	583	4	tempting	tempt	VBG
cord-336510-qzm9wgde	583	5	to	to	TO
cord-336510-qzm9wgde	583	6	speculate	speculate	VB
cord-336510-qzm9wgde	583	7	that	that	IN
cord-336510-qzm9wgde	583	8	the	the	DT
cord-336510-qzm9wgde	583	9	NF	NF	NNP
cord-336510-qzm9wgde	583	10	-	-	HYPH
cord-336510-qzm9wgde	583	11	κB	κB	NNP
cord-336510-qzm9wgde	583	12	-	-	HYPH
cord-336510-qzm9wgde	583	13	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	583	14	complex	complex	NN
cord-336510-qzm9wgde	583	15	has	have	VBZ
cord-336510-qzm9wgde	583	16	higher	high	JJR
cord-336510-qzm9wgde	583	17	affinity	affinity	NN
cord-336510-qzm9wgde	583	18	for	for	IN
cord-336510-qzm9wgde	583	19	the	the	DT
cord-336510-qzm9wgde	583	20	combined	combine	VBN
cord-336510-qzm9wgde	583	21	DNA	dna	NN
cord-336510-qzm9wgde	583	22	-	-	HYPH
cord-336510-qzm9wgde	583	23	binding	bind	VBG
cord-336510-qzm9wgde	583	24	site	site	NN
cord-336510-qzm9wgde	583	25	and	and	CC
cord-336510-qzm9wgde	583	26	thus	thus	RB
cord-336510-qzm9wgde	583	27	is	be	VBZ
cord-336510-qzm9wgde	583	28	able	able	JJ
cord-336510-qzm9wgde	583	29	to	to	TO
cord-336510-qzm9wgde	583	30	obstruct	obstruct	VB
cord-336510-qzm9wgde	583	31	the	the	DT
cord-336510-qzm9wgde	583	32	binding	binding	NN
cord-336510-qzm9wgde	583	33	of	of	IN
cord-336510-qzm9wgde	583	34	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	583	35	to	to	IN
cord-336510-qzm9wgde	583	36	the	the	DT
cord-336510-qzm9wgde	583	37	ISRE	ISRE	NNP
cord-336510-qzm9wgde	583	38	site	site	NN
cord-336510-qzm9wgde	583	39	of	of	IN
cord-336510-qzm9wgde	583	40	the	the	DT
cord-336510-qzm9wgde	583	41	iNOS	inos	JJ
cord-336510-qzm9wgde	583	42	promoter	promoter	NN
cord-336510-qzm9wgde	583	43	and	and	CC
cord-336510-qzm9wgde	583	44	in	in	IN
cord-336510-qzm9wgde	583	45	that	that	DT
cord-336510-qzm9wgde	583	46	way	way	NN
cord-336510-qzm9wgde	583	47	turn	turn	VBP
cord-336510-qzm9wgde	583	48	the	the	DT
cord-336510-qzm9wgde	583	49	competition	competition	NN
cord-336510-qzm9wgde	583	50	towards	towards	IN
cord-336510-qzm9wgde	583	51	transcriptional	transcriptional	JJ
cord-336510-qzm9wgde	583	52	activity	activity	NN
cord-336510-qzm9wgde	583	53	(	(	-LRB-
cord-336510-qzm9wgde	583	54	fig	fig	NN
cord-336510-qzm9wgde	583	55	.	.	.
cord-336510-qzm9wgde	583	56	5	5	LS
cord-336510-qzm9wgde	583	57	)	)	-RRB-
cord-336510-qzm9wgde	584	1	[	[	-LRB-
cord-336510-qzm9wgde	584	2	411	411	CD
cord-336510-qzm9wgde	584	3	]	]	-RRB-
cord-336510-qzm9wgde	584	4	.	.	.
cord-336510-qzm9wgde	585	1	This	this	DT
cord-336510-qzm9wgde	585	2	will	will	MD
cord-336510-qzm9wgde	585	3	block	block	VB
cord-336510-qzm9wgde	585	4	the	the	DT
cord-336510-qzm9wgde	585	5	inhibiting	inhibit	VBG
cord-336510-qzm9wgde	585	6	effect	effect	NN
cord-336510-qzm9wgde	585	7	of	of	IN
cord-336510-qzm9wgde	585	8	IL-4	IL-4	NNP
cord-336510-qzm9wgde	585	9	in	in	IN
cord-336510-qzm9wgde	585	10	foci	foci	NN
cord-336510-qzm9wgde	585	11	of	of	IN
cord-336510-qzm9wgde	585	12	HSV	HSV	NNP
cord-336510-qzm9wgde	585	13	replication	replication	NN
cord-336510-qzm9wgde	585	14	and	and	CC
cord-336510-qzm9wgde	585	15	open	open	VB
cord-336510-qzm9wgde	585	16	up	up	RP
cord-336510-qzm9wgde	585	17	for	for	IN
cord-336510-qzm9wgde	585	18	NO	no	DT
cord-336510-qzm9wgde	585	19	production	production	NN
cord-336510-qzm9wgde	585	20	at	at	IN
cord-336510-qzm9wgde	585	21	sites	site	NNS
cord-336510-qzm9wgde	585	22	where	where	WRB
cord-336510-qzm9wgde	585	23	the	the	DT
cord-336510-qzm9wgde	585	24	antiviral	antiviral	JJ
cord-336510-qzm9wgde	585	25	effect	effect	NN
cord-336510-qzm9wgde	585	26	is	be	VBZ
cord-336510-qzm9wgde	585	27	of	of	IN
cord-336510-qzm9wgde	585	28	more	more	JJR
cord-336510-qzm9wgde	585	29	importance	importance	NN
cord-336510-qzm9wgde	585	30	than	than	IN
cord-336510-qzm9wgde	585	31	the	the	DT
cord-336510-qzm9wgde	585	32	potential	potential	JJ
cord-336510-qzm9wgde	585	33	toxicity	toxicity	NN
cord-336510-qzm9wgde	585	34	.	.	.
cord-336510-qzm9wgde	586	1	In	in	IN
cord-336510-qzm9wgde	586	2	treatment	treatment	NN
cord-336510-qzm9wgde	586	3	of	of	IN
cord-336510-qzm9wgde	586	4	HSV	HSV	NNP
cord-336510-qzm9wgde	586	5	infections	infection	NNS
cord-336510-qzm9wgde	586	6	,	,	,
cord-336510-qzm9wgde	586	7	we	-PRON-	PRP
cord-336510-qzm9wgde	586	8	have	have	VBP
cord-336510-qzm9wgde	586	9	for	for	IN
cord-336510-qzm9wgde	586	10	many	many	JJ
cord-336510-qzm9wgde	586	11	years	year	NNS
cord-336510-qzm9wgde	586	12	had	have	VBD
cord-336510-qzm9wgde	586	13	a	a	DT
cord-336510-qzm9wgde	586	14	very	very	RB
cord-336510-qzm9wgde	586	15	powerful	powerful	JJ
cord-336510-qzm9wgde	586	16	tool	tool	NN
cord-336510-qzm9wgde	586	17	in	in	IN
cord-336510-qzm9wgde	586	18	the	the	DT
cord-336510-qzm9wgde	586	19	antiherpetic	antiherpetic	JJ
cord-336510-qzm9wgde	586	20	drug	drug	NN
cord-336510-qzm9wgde	586	21	acyclovir	acyclovir	NNP
cord-336510-qzm9wgde	586	22	and	and	CC
cord-336510-qzm9wgde	586	23	related	related	JJ
cord-336510-qzm9wgde	586	24	compounds	compound	NNS
cord-336510-qzm9wgde	586	25	.	.	.
cord-336510-qzm9wgde	587	1	But	but	CC
cord-336510-qzm9wgde	587	2	there	there	EX
cord-336510-qzm9wgde	587	3	are	be	VBP
cord-336510-qzm9wgde	587	4	still	still	RB
cord-336510-qzm9wgde	587	5	therapeutic	therapeutic	JJ
cord-336510-qzm9wgde	587	6	problems	problem	NNS
cord-336510-qzm9wgde	587	7	in	in	IN
cord-336510-qzm9wgde	587	8	the	the	DT
cord-336510-qzm9wgde	587	9	group	group	NN
cord-336510-qzm9wgde	587	10	of	of	IN
cord-336510-qzm9wgde	587	11	patients	patient	NNS
cord-336510-qzm9wgde	587	12	with	with	IN
cord-336510-qzm9wgde	587	13	generalized	generalized	JJ
cord-336510-qzm9wgde	587	14	or	or	CC
cord-336510-qzm9wgde	587	15	CNS	cns	JJ
cord-336510-qzm9wgde	587	16	infections	infection	NNS
cord-336510-qzm9wgde	587	17	,	,	,
cord-336510-qzm9wgde	587	18	and	and	CC
cord-336510-qzm9wgde	587	19	therefore	therefore	RB
cord-336510-qzm9wgde	587	20	it	-PRON-	PRP
cord-336510-qzm9wgde	587	21	is	be	VBZ
cord-336510-qzm9wgde	587	22	tempting	tempting	JJ
cord-336510-qzm9wgde	587	23	and	and	CC
cord-336510-qzm9wgde	587	24	timely	timely	JJ
cord-336510-qzm9wgde	587	25	to	to	TO
cord-336510-qzm9wgde	587	26	hypothesize	hypothesize	VB
cord-336510-qzm9wgde	587	27	on	on	IN
cord-336510-qzm9wgde	587	28	possible	possible	JJ
cord-336510-qzm9wgde	587	29	future	future	JJ
cord-336510-qzm9wgde	587	30	treatment	treatment	NN
cord-336510-qzm9wgde	587	31	strategies	strategy	NNS
cord-336510-qzm9wgde	587	32	.	.	.
cord-336510-qzm9wgde	588	1	As	as	IN
cord-336510-qzm9wgde	588	2	described	describe	VBN
cord-336510-qzm9wgde	588	3	,	,	,
cord-336510-qzm9wgde	588	4	it	-PRON-	PRP
cord-336510-qzm9wgde	588	5	is	be	VBZ
cord-336510-qzm9wgde	588	6	clear	clear	JJ
cord-336510-qzm9wgde	588	7	that	that	IN
cord-336510-qzm9wgde	588	8	relatively	relatively	RB
cord-336510-qzm9wgde	588	9	discrete	discrete	JJ
cord-336510-qzm9wgde	588	10	but	but	CC
cord-336510-qzm9wgde	588	11	early	early	JJ
cord-336510-qzm9wgde	588	12	actions	action	NNS
cord-336510-qzm9wgde	588	13	of	of	IN
cord-336510-qzm9wgde	588	14	the	the	DT
cord-336510-qzm9wgde	588	15	non	non	JJ
cord-336510-qzm9wgde	588	16	-	-	JJ
cord-336510-qzm9wgde	588	17	specific	specific	JJ
cord-336510-qzm9wgde	588	18	defence	defence	NN
cord-336510-qzm9wgde	588	19	systems	system	NNS
cord-336510-qzm9wgde	588	20	are	be	VBP
cord-336510-qzm9wgde	588	21	crucial	crucial	JJ
cord-336510-qzm9wgde	588	22	for	for	IN
cord-336510-qzm9wgde	588	23	the	the	DT
cord-336510-qzm9wgde	588	24	long	long	JJ
cord-336510-qzm9wgde	588	25	term	term	NN
cord-336510-qzm9wgde	588	26	outcome	outcome	NN
cord-336510-qzm9wgde	588	27	of	of	IN
cord-336510-qzm9wgde	588	28	the	the	DT
cord-336510-qzm9wgde	588	29	infection	infection	NN
cord-336510-qzm9wgde	588	30	.	.	.
cord-336510-qzm9wgde	589	1	The	the	DT
cord-336510-qzm9wgde	589	2	same	same	JJ
cord-336510-qzm9wgde	589	3	holds	hold	VBZ
cord-336510-qzm9wgde	589	4	for	for	IN
cord-336510-qzm9wgde	589	5	the	the	DT
cord-336510-qzm9wgde	589	6	antiviral	antiviral	JJ
cord-336510-qzm9wgde	589	7	therapy	therapy	NN
cord-336510-qzm9wgde	589	8	,	,	,
cord-336510-qzm9wgde	589	9	and	and	CC
cord-336510-qzm9wgde	589	10	early	early	JJ
cord-336510-qzm9wgde	589	11	presumptive	presumptive	JJ
cord-336510-qzm9wgde	589	12	therapy	therapy	NN
cord-336510-qzm9wgde	589	13	and	and	CC
cord-336510-qzm9wgde	589	14	rapid	rapid	JJ
cord-336510-qzm9wgde	589	15	diagnostics	diagnostic	NNS
cord-336510-qzm9wgde	589	16	could	could	MD
cord-336510-qzm9wgde	589	17	thus	thus	RB
cord-336510-qzm9wgde	589	18	potentially	potentially	RB
cord-336510-qzm9wgde	589	19	improve	improve	VB
cord-336510-qzm9wgde	589	20	the	the	DT
cord-336510-qzm9wgde	589	21	final	final	JJ
cord-336510-qzm9wgde	589	22	outcome	outcome	NN
cord-336510-qzm9wgde	589	23	.	.	.
cord-336510-qzm9wgde	590	1	In	in	IN
cord-336510-qzm9wgde	590	2	the	the	DT
cord-336510-qzm9wgde	590	3	seeking	seeking	NN
cord-336510-qzm9wgde	590	4	for	for	IN
cord-336510-qzm9wgde	590	5	improved	improved	JJ
cord-336510-qzm9wgde	590	6	antiviral	antiviral	JJ
cord-336510-qzm9wgde	590	7	treatment	treatment	NN
cord-336510-qzm9wgde	590	8	,	,	,
cord-336510-qzm9wgde	590	9	adjuvant	adjuvant	JJ
cord-336510-qzm9wgde	590	10	therapy	therapy	NN
cord-336510-qzm9wgde	590	11	with	with	IN
cord-336510-qzm9wgde	590	12	anti	anti	JJ
cord-336510-qzm9wgde	590	13	-	-	JJ
cord-336510-qzm9wgde	590	14	HSV	hsv	JJ
cord-336510-qzm9wgde	590	15	antibodies	antibody	NNS
cord-336510-qzm9wgde	590	16	could	could	MD
cord-336510-qzm9wgde	590	17	potentially	potentially	RB
cord-336510-qzm9wgde	590	18	accelerate	accelerate	VB
cord-336510-qzm9wgde	590	19	the	the	DT
cord-336510-qzm9wgde	590	20	clearance	clearance	NN
cord-336510-qzm9wgde	590	21	of	of	IN
cord-336510-qzm9wgde	590	22	viral	viral	JJ
cord-336510-qzm9wgde	590	23	particles	particle	NNS
cord-336510-qzm9wgde	590	24	,	,	,
cord-336510-qzm9wgde	590	25	and	and	CC
cord-336510-qzm9wgde	590	26	block	block	VB
cord-336510-qzm9wgde	590	27	viremic	viremic	JJ
cord-336510-qzm9wgde	590	28	dissemination	dissemination	NN
cord-336510-qzm9wgde	590	29	in	in	IN
cord-336510-qzm9wgde	590	30	patients	patient	NNS
cord-336510-qzm9wgde	590	31	,	,	,
cord-336510-qzm9wgde	590	32	who	who	WP
cord-336510-qzm9wgde	590	33	are	be	VBP
cord-336510-qzm9wgde	590	34	still	still	RB
cord-336510-qzm9wgde	590	35	seronegative	seronegative	JJ
cord-336510-qzm9wgde	590	36	at	at	IN
cord-336510-qzm9wgde	590	37	the	the	DT
cord-336510-qzm9wgde	590	38	time	time	NN
cord-336510-qzm9wgde	590	39	of	of	IN
cord-336510-qzm9wgde	590	40	treatment	treatment	NN
cord-336510-qzm9wgde	590	41	.	.	.
cord-336510-qzm9wgde	591	1	Immunomodulatory	immunomodulatory	JJ
cord-336510-qzm9wgde	591	2	treatment	treatment	NN
cord-336510-qzm9wgde	591	3	modalities	modality	NNS
cord-336510-qzm9wgde	591	4	imitating	imitate	VBG
cord-336510-qzm9wgde	591	5	the	the	DT
cord-336510-qzm9wgde	591	6	early	early	JJ
cord-336510-qzm9wgde	591	7	non	non	JJ
cord-336510-qzm9wgde	591	8	-	-	JJ
cord-336510-qzm9wgde	591	9	specific	specific	JJ
cord-336510-qzm9wgde	591	10	antiviral	antiviral	JJ
cord-336510-qzm9wgde	591	11	defence	defence	NN
cord-336510-qzm9wgde	591	12	,	,	,
cord-336510-qzm9wgde	591	13	working	work	VBG
cord-336510-qzm9wgde	591	14	as	as	IN
cord-336510-qzm9wgde	591	15	described	describe	VBN
cord-336510-qzm9wgde	591	16	in	in	IN
cord-336510-qzm9wgde	591	17	this	this	DT
cord-336510-qzm9wgde	591	18	review	review	NN
cord-336510-qzm9wgde	591	19	,	,	,
cord-336510-qzm9wgde	591	20	could	could	MD
cord-336510-qzm9wgde	591	21	be	be	VB
cord-336510-qzm9wgde	591	22	considered	consider	VBN
cord-336510-qzm9wgde	591	23	.	.	.
cord-336510-qzm9wgde	592	1	The	the	DT
cord-336510-qzm9wgde	592	2	key	key	JJ
cord-336510-qzm9wgde	592	3	players	player	NNS
cord-336510-qzm9wgde	592	4	exhibiting	exhibit	VBG
cord-336510-qzm9wgde	592	5	the	the	DT
cord-336510-qzm9wgde	592	6	least	least	JJS
cord-336510-qzm9wgde	592	7	toxicity	toxicity	NN
cord-336510-qzm9wgde	592	8	by	by	IN
cord-336510-qzm9wgde	592	9	themselves	-PRON-	PRP
cord-336510-qzm9wgde	592	10	could	could	MD
cord-336510-qzm9wgde	592	11	be	be	VB
cord-336510-qzm9wgde	592	12	used	use	VBN
cord-336510-qzm9wgde	592	13	,	,	,
cord-336510-qzm9wgde	592	14	taking	take	VBG
cord-336510-qzm9wgde	592	15	advantage	advantage	NN
cord-336510-qzm9wgde	592	16	of	of	IN
cord-336510-qzm9wgde	592	17	potential	potential	JJ
cord-336510-qzm9wgde	592	18	synergy	synergy	NN
cord-336510-qzm9wgde	592	19	with	with	IN
cord-336510-qzm9wgde	592	20	other	other	JJ
cord-336510-qzm9wgde	592	21	cytokines	cytokine	NNS
cord-336510-qzm9wgde	592	22	in	in	IN
cord-336510-qzm9wgde	592	23	the	the	DT
cord-336510-qzm9wgde	592	24	foci	foci	NN
cord-336510-qzm9wgde	592	25	of	of	IN
cord-336510-qzm9wgde	592	26	HSV	HSV	NNP
cord-336510-qzm9wgde	592	27	infection	infection	NN
cord-336510-qzm9wgde	592	28	.	.	.
cord-336510-qzm9wgde	593	1	In	in	IN
cord-336510-qzm9wgde	593	2	the	the	DT
cord-336510-qzm9wgde	593	3	future	future	NN
cord-336510-qzm9wgde	593	4	,	,	,
cord-336510-qzm9wgde	593	5	molecules	molecule	NNS
cord-336510-qzm9wgde	593	6	with	with	IN
cord-336510-qzm9wgde	593	7	affinity	affinity	NN
cord-336510-qzm9wgde	593	8	for	for	IN
cord-336510-qzm9wgde	593	9	various	various	JJ
cord-336510-qzm9wgde	593	10	receptors	receptor	NNS
cord-336510-qzm9wgde	593	11	are	be	VBP
cord-336510-qzm9wgde	593	12	expected	expect	VBN
cord-336510-qzm9wgde	593	13	to	to	TO
cord-336510-qzm9wgde	593	14	be	be	VB
cord-336510-qzm9wgde	593	15	produced	produce	VBN
cord-336510-qzm9wgde	593	16	,	,	,
cord-336510-qzm9wgde	593	17	and	and	CC
cord-336510-qzm9wgde	593	18	when	when	WRB
cord-336510-qzm9wgde	593	19	we	-PRON-	PRP
cord-336510-qzm9wgde	593	20	know	know	VBP
cord-336510-qzm9wgde	593	21	the	the	DT
cord-336510-qzm9wgde	593	22	signalling	signal	VBG
cord-336510-qzm9wgde	593	23	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	593	24	in	in	IN
cord-336510-qzm9wgde	593	25	detail	detail	NN
cord-336510-qzm9wgde	593	26	and	and	CC
cord-336510-qzm9wgde	593	27	all	all	PDT
cord-336510-qzm9wgde	593	28	the	the	DT
cord-336510-qzm9wgde	593	29	potential	potential	JJ
cord-336510-qzm9wgde	593	30	interactions	interaction	NNS
cord-336510-qzm9wgde	593	31	,	,	,
cord-336510-qzm9wgde	593	32	molecular	molecular	JJ
cord-336510-qzm9wgde	593	33	signalling	signalling	NN
cord-336510-qzm9wgde	593	34	could	could	MD
cord-336510-qzm9wgde	593	35	be	be	VB
cord-336510-qzm9wgde	593	36	addressed	address	VBN
cord-336510-qzm9wgde	593	37	directly	directly	RB
cord-336510-qzm9wgde	593	38	by	by	IN
cord-336510-qzm9wgde	593	39	pharmaceuticals	pharmaceutical	NNS
cord-336510-qzm9wgde	593	40	.	.	.
cord-336510-qzm9wgde	594	1	In	in	IN
cord-336510-qzm9wgde	594	2	consequence	consequence	NN
cord-336510-qzm9wgde	594	3	of	of	IN
cord-336510-qzm9wgde	594	4	the	the	DT
cord-336510-qzm9wgde	594	5	crucial	crucial	JJ
cord-336510-qzm9wgde	594	6	position	position	NN
cord-336510-qzm9wgde	594	7	of	of	IN
cord-336510-qzm9wgde	594	8	the	the	DT
cord-336510-qzm9wgde	594	9	type	type	NN
cord-336510-qzm9wgde	594	10	I	-PRON-	PRP
cord-336510-qzm9wgde	594	11	IFNs	ifns	VBP
cord-336510-qzm9wgde	594	12	in	in	IN
cord-336510-qzm9wgde	594	13	innate	innate	JJ
cord-336510-qzm9wgde	594	14	response	response	NN
cord-336510-qzm9wgde	594	15	to	to	IN
cord-336510-qzm9wgde	594	16	HSV	HSV	NNP
cord-336510-qzm9wgde	594	17	,	,	,
cord-336510-qzm9wgde	594	18	future	future	JJ
cord-336510-qzm9wgde	594	19	analogues	analogue	NNS
cord-336510-qzm9wgde	594	20	of	of	IN
cord-336510-qzm9wgde	594	21	IFN	IFN	NNP
cord-336510-qzm9wgde	594	22	-	-	HYPH
cord-336510-qzm9wgde	594	23	α	α	NNP
cord-336510-qzm9wgde	594	24	/	/	SYM
cord-336510-qzm9wgde	594	25	β	β	NN
cord-336510-qzm9wgde	594	26	seem	seem	VBP
cord-336510-qzm9wgde	594	27	obvious	obvious	JJ
cord-336510-qzm9wgde	594	28	as	as	IN
cord-336510-qzm9wgde	594	29	candidates	candidate	NNS
cord-336510-qzm9wgde	594	30	for	for	IN
cord-336510-qzm9wgde	594	31	adjuvant	adjuvant	JJ
cord-336510-qzm9wgde	594	32	treatment	treatment	NN
cord-336510-qzm9wgde	594	33	of	of	IN
cord-336510-qzm9wgde	594	34	severe	severe	JJ
cord-336510-qzm9wgde	594	35	HSV	HSV	NNP
cord-336510-qzm9wgde	594	36	infections	infection	NNS
cord-336510-qzm9wgde	594	37	.	.	.
cord-336510-qzm9wgde	595	1	This	this	DT
cord-336510-qzm9wgde	595	2	could	could	MD
cord-336510-qzm9wgde	595	3	be	be	VB
cord-336510-qzm9wgde	595	4	supplemented	supplement	VBN
cord-336510-qzm9wgde	595	5	with	with	IN
cord-336510-qzm9wgde	595	6	IL-12	IL-12	NNP
cord-336510-qzm9wgde	595	7	,	,	,
cord-336510-qzm9wgde	595	8	which	which	WDT
cord-336510-qzm9wgde	595	9	would	would	MD
cord-336510-qzm9wgde	595	10	give	give	VB
cord-336510-qzm9wgde	595	11	the	the	DT
cord-336510-qzm9wgde	595	12	highest	high	JJS
cord-336510-qzm9wgde	595	13	IFN	IFN	NNP
cord-336510-qzm9wgde	595	14	-	-	HYPH
cord-336510-qzm9wgde	595	15	γ	γ	NN
cord-336510-qzm9wgde	595	16	production	production	NN
cord-336510-qzm9wgde	595	17	in	in	IN
cord-336510-qzm9wgde	595	18	foci	foci	NN
cord-336510-qzm9wgde	595	19	of	of	IN
cord-336510-qzm9wgde	595	20	HSV	HSV	NNP
cord-336510-qzm9wgde	595	21	infection	infection	NN
cord-336510-qzm9wgde	595	22	because	because	IN
cord-336510-qzm9wgde	595	23	of	of	IN
cord-336510-qzm9wgde	595	24	other	other	JJ
cord-336510-qzm9wgde	595	25	cytokines	cytokine	NNS
cord-336510-qzm9wgde	595	26	such	such	JJ
cord-336510-qzm9wgde	595	27	as	as	IN
cord-336510-qzm9wgde	595	28	IFN	IFN	NNP
cord-336510-qzm9wgde	595	29	-	-	HYPH
cord-336510-qzm9wgde	595	30	α	α	NNP
cord-336510-qzm9wgde	595	31	/	/	SYM
cord-336510-qzm9wgde	595	32	β	β	NN
cord-336510-qzm9wgde	595	33	,	,	,
cord-336510-qzm9wgde	595	34	TNF	TNF	NNP
cord-336510-qzm9wgde	595	35	and	and	CC
cord-336510-qzm9wgde	595	36	IL-18	IL-18	NNP
cord-336510-qzm9wgde	595	37	being	be	VBG
cord-336510-qzm9wgde	595	38	present	present	JJ
cord-336510-qzm9wgde	595	39	there	there	RB
cord-336510-qzm9wgde	595	40	.	.	.
cord-336510-qzm9wgde	596	1	With	with	IN
cord-336510-qzm9wgde	596	2	focussed	focussed	JJ
cord-336510-qzm9wgde	596	3	production	production	NN
cord-336510-qzm9wgde	596	4	of	of	IN
cord-336510-qzm9wgde	596	5	IFN	IFN	NNP
cord-336510-qzm9wgde	596	6	-	-	HYPH
cord-336510-qzm9wgde	596	7	γ	γ	NNP
cord-336510-qzm9wgde	596	8	at	at	IN
cord-336510-qzm9wgde	596	9	sites	site	NNS
cord-336510-qzm9wgde	596	10	of	of	IN
cord-336510-qzm9wgde	596	11	active	active	JJ
cord-336510-qzm9wgde	596	12	viral	viral	JJ
cord-336510-qzm9wgde	596	13	replication	replication	NN
cord-336510-qzm9wgde	596	14	and	and	CC
cord-336510-qzm9wgde	596	15	treatment	treatment	NN
cord-336510-qzm9wgde	596	16	with	with	IN
cord-336510-qzm9wgde	596	17	IFN	IFN	NNP
cord-336510-qzm9wgde	596	18	type	type	NN
cord-336510-qzm9wgde	597	1	I	-PRON-	PRP
cord-336510-qzm9wgde	597	2	analogues	analogue	NNS
cord-336510-qzm9wgde	598	1	the	the	DT
cord-336510-qzm9wgde	598	2	focal	focal	JJ
cord-336510-qzm9wgde	598	3	antiviral	antiviral	JJ
cord-336510-qzm9wgde	598	4	activity	activity	NN
cord-336510-qzm9wgde	598	5	could	could	MD
cord-336510-qzm9wgde	598	6	be	be	VB
cord-336510-qzm9wgde	598	7	increased	increase	VBN
cord-336510-qzm9wgde	598	8	markedly	markedly	RB
cord-336510-qzm9wgde	598	9	,	,	,
cord-336510-qzm9wgde	598	10	without	without	IN
cord-336510-qzm9wgde	598	11	too	too	RB
cord-336510-qzm9wgde	598	12	much	much	JJ
cord-336510-qzm9wgde	598	13	activity	activity	NN
cord-336510-qzm9wgde	598	14	in	in	IN
cord-336510-qzm9wgde	598	15	areas	area	NNS
cord-336510-qzm9wgde	598	16	without	without	IN
cord-336510-qzm9wgde	598	17	infection	infection	NN
cord-336510-qzm9wgde	598	18	.	.	.
cord-336510-qzm9wgde	599	1	To	to	TO
cord-336510-qzm9wgde	599	2	hamper	hamper	VB
cord-336510-qzm9wgde	599	3	systemic	systemic	JJ
cord-336510-qzm9wgde	599	4	consequences	consequence	NNS
cord-336510-qzm9wgde	599	5	of	of	IN
cord-336510-qzm9wgde	599	6	the	the	DT
cord-336510-qzm9wgde	599	7	enhanced	enhanced	JJ
cord-336510-qzm9wgde	599	8	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	599	9	reactions	reaction	NNS
cord-336510-qzm9wgde	599	10	,	,	,
cord-336510-qzm9wgde	599	11	such	such	JJ
cord-336510-qzm9wgde	599	12	pro	pro	JJ
cord-336510-qzm9wgde	599	13	-	-	JJ
cord-336510-qzm9wgde	599	14	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	599	15	treatment	treatment	NN
cord-336510-qzm9wgde	599	16	could	could	MD
cord-336510-qzm9wgde	599	17	perhaps	perhaps	RB
cord-336510-qzm9wgde	599	18	benefit	benefit	VB
cord-336510-qzm9wgde	599	19	from	from	IN
cord-336510-qzm9wgde	599	20	concomitant	concomitant	JJ
cord-336510-qzm9wgde	599	21	treatment	treatment	NN
cord-336510-qzm9wgde	599	22	with	with	IN
cord-336510-qzm9wgde	599	23	IL-4	IL-4	NNP
cord-336510-qzm9wgde	599	24	or	or	CC
cord-336510-qzm9wgde	599	25	other	other	JJ
cord-336510-qzm9wgde	599	26	STAT6-activating	stat6-activate	VBG
cord-336510-qzm9wgde	599	27	therapeutics	therapeutic	NNS
cord-336510-qzm9wgde	599	28	in	in	IN
cord-336510-qzm9wgde	599	29	the	the	DT
cord-336510-qzm9wgde	599	30	future	future	NN
cord-336510-qzm9wgde	599	31	.	.	.
cord-336510-qzm9wgde	600	1	This	this	DT
cord-336510-qzm9wgde	600	2	would	would	MD
cord-336510-qzm9wgde	600	3	further	further	RB
cord-336510-qzm9wgde	600	4	focus	focus	VB
cord-336510-qzm9wgde	600	5	the	the	DT
cord-336510-qzm9wgde	600	6	activity	activity	NN
cord-336510-qzm9wgde	600	7	to	to	IN
cord-336510-qzm9wgde	600	8	sites	site	NNS
cord-336510-qzm9wgde	600	9	of	of	IN
cord-336510-qzm9wgde	600	10	active	active	JJ
cord-336510-qzm9wgde	600	11	HSV	HSV	NNP
cord-336510-qzm9wgde	600	12	replication	replication	NN
cord-336510-qzm9wgde	600	13	.	.	.
cord-336510-qzm9wgde	601	1	In	in	IN
cord-336510-qzm9wgde	601	2	situations	situation	NNS
cord-336510-qzm9wgde	601	3	with	with	IN
cord-336510-qzm9wgde	601	4	massive	massive	JJ
cord-336510-qzm9wgde	601	5	viral	viral	JJ
cord-336510-qzm9wgde	601	6	replication	replication	NN
cord-336510-qzm9wgde	601	7	in	in	IN
cord-336510-qzm9wgde	601	8	nearly	nearly	RB
cord-336510-qzm9wgde	601	9	all	all	DT
cord-336510-qzm9wgde	601	10	organs	organ	NNS
cord-336510-qzm9wgde	601	11	,	,	,
cord-336510-qzm9wgde	601	12	high	high	JJ
cord-336510-qzm9wgde	601	13	-	-	HYPH
cord-336510-qzm9wgde	601	14	dose	dose	NN
cord-336510-qzm9wgde	601	15	aciclovir	aciclovir	NNS
cord-336510-qzm9wgde	601	16	should	should	MD
cord-336510-qzm9wgde	601	17	perhaps	perhaps	RB
cord-336510-qzm9wgde	601	18	only	only	RB
cord-336510-qzm9wgde	601	19	be	be	VB
cord-336510-qzm9wgde	601	20	supplemented	supplement	VBN
cord-336510-qzm9wgde	601	21	with	with	IN
cord-336510-qzm9wgde	601	22	anti	anti	JJ
cord-336510-qzm9wgde	601	23	-	-	JJ
cord-336510-qzm9wgde	601	24	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	601	25	medications	medication	NNS
cord-336510-qzm9wgde	601	26	and	and	CC
cord-336510-qzm9wgde	601	27	inhibitors	inhibitor	NNS
cord-336510-qzm9wgde	601	28	of	of	IN
cord-336510-qzm9wgde	601	29	TNF	TNF	NNP
cord-336510-qzm9wgde	601	30	,	,	,
cord-336510-qzm9wgde	601	31	since	since	IN
cord-336510-qzm9wgde	601	32	many	many	JJ
cord-336510-qzm9wgde	601	33	of	of	IN
cord-336510-qzm9wgde	601	34	these	these	DT
cord-336510-qzm9wgde	601	35	individuals	individual	NNS
cord-336510-qzm9wgde	601	36	risk	risk	VBP
cord-336510-qzm9wgde	601	37	to	to	TO
cord-336510-qzm9wgde	601	38	die	die	VB
cord-336510-qzm9wgde	601	39	from	from	IN
cord-336510-qzm9wgde	601	40	septic	septic	JJ
cord-336510-qzm9wgde	601	41	reactions	reaction	NNS
cord-336510-qzm9wgde	601	42	.	.	.
cord-336510-qzm9wgde	602	1	The	the	DT
cord-336510-qzm9wgde	602	2	author(s	author(s	NNP
cord-336510-qzm9wgde	602	3	)	)	-RRB-
cord-336510-qzm9wgde	602	4	declare	declare	VBP
cord-336510-qzm9wgde	602	5	that	that	IN
cord-336510-qzm9wgde	602	6	they	-PRON-	PRP
cord-336510-qzm9wgde	602	7	have	have	VBP
cord-336510-qzm9wgde	602	8	no	no	DT
cord-336510-qzm9wgde	602	9	competing	compete	VBG
cord-336510-qzm9wgde	602	10	interests	interest	NNS
cord-336510-qzm9wgde	602	11	.	.	.
cord-336510-qzm9wgde	602	12	 	 	_SP
cord-336510-qzm9wgde	603	1	The	the	DT
cord-336510-qzm9wgde	603	2	family	family	NN
cord-336510-qzm9wgde	603	3	Herpesviridae	Herpesviridae	NNP
cord-336510-qzm9wgde	603	4	:	:	:
cord-336510-qzm9wgde	603	5	A	a	DT
cord-336510-qzm9wgde	603	6	brief	brief	JJ
cord-336510-qzm9wgde	603	7	introduction	introduction	NN
cord-336510-qzm9wgde	603	8	Cercopithecine	Cercopithecine	NNP
cord-336510-qzm9wgde	603	9	herpesvirus	herpesvirus	NN
cord-336510-qzm9wgde	603	10	(	(	-LRB-
cord-336510-qzm9wgde	603	11	B	b	NN
cord-336510-qzm9wgde	603	12	virus	virus	NN
cord-336510-qzm9wgde	603	13	)	)	-RRB-
cord-336510-qzm9wgde	604	1	Aetiologische	Aetiologische	NNP
cord-336510-qzm9wgde	604	2	untersuchungen	untersuchungen	NNP
cord-336510-qzm9wgde	604	3	über	über	NNP
cord-336510-qzm9wgde	604	4	der	der	NNP
cord-336510-qzm9wgde	604	5	fieberhaften	fieberhaften	NNP
cord-336510-qzm9wgde	604	6	,	,	,
cord-336510-qzm9wgde	604	7	herpes	herpes	NNP
cord-336510-qzm9wgde	604	8	Serologische	Serologische	NNP
cord-336510-qzm9wgde	604	9	untersuchungen	untersuchungen	NNP
cord-336510-qzm9wgde	604	10	zur	zur	NNP
cord-336510-qzm9wgde	604	11	typendifferenzierung	typendifferenzierung	NNP
cord-336510-qzm9wgde	604	12	des	des	FW
cord-336510-qzm9wgde	604	13	herpesvirus	herpesvirus	NNP
cord-336510-qzm9wgde	604	14	hominis	hominis	NN
cord-336510-qzm9wgde	604	15	Definition	Definition	NNP
cord-336510-qzm9wgde	604	16	,	,	,
cord-336510-qzm9wgde	604	17	provisional	provisional	JJ
cord-336510-qzm9wgde	604	18	nomenclature	nomenclature	NN
cord-336510-qzm9wgde	604	19	,	,	,
cord-336510-qzm9wgde	604	20	and	and	CC
cord-336510-qzm9wgde	604	21	taxonomy	taxonomy	NN
cord-336510-qzm9wgde	604	22	.	.	.
cord-336510-qzm9wgde	605	1	The	the	DT
cord-336510-qzm9wgde	605	2	Herpesvirus	Herpesvirus	NNP
cord-336510-qzm9wgde	605	3	Study	Study	NNP
cord-336510-qzm9wgde	605	4	Group	Group	NNP
cord-336510-qzm9wgde	605	5	,	,	,
cord-336510-qzm9wgde	605	6	the	the	DT
cord-336510-qzm9wgde	605	7	International	International	NNP
cord-336510-qzm9wgde	605	8	Committee	Committee	NNP
cord-336510-qzm9wgde	605	9	on	on	IN
cord-336510-qzm9wgde	605	10	Taxonomy	Taxonomy	NNP
cord-336510-qzm9wgde	605	11	of	of	IN
cord-336510-qzm9wgde	605	12	Viruses	Viruses	NNPS
cord-336510-qzm9wgde	606	1	The	the	DT
cord-336510-qzm9wgde	606	2	genome	genome	NN
cord-336510-qzm9wgde	606	3	sequence	sequence	NN
cord-336510-qzm9wgde	606	4	of	of	IN
cord-336510-qzm9wgde	606	5	herpes	herpes	NNP
cord-336510-qzm9wgde	606	6	simplex	simplex	NNP
cord-336510-qzm9wgde	606	7	virus	virus	NN
cord-336510-qzm9wgde	606	8	type	type	NN
cord-336510-qzm9wgde	606	9	2	2	CD
cord-336510-qzm9wgde	606	10	The	the	DT
cord-336510-qzm9wgde	606	11	complete	complete	JJ
cord-336510-qzm9wgde	606	12	DNA	dna	NN
cord-336510-qzm9wgde	606	13	sequence	sequence	NN
cord-336510-qzm9wgde	606	14	of	of	IN
cord-336510-qzm9wgde	606	15	the	the	DT
cord-336510-qzm9wgde	606	16	long	long	JJ
cord-336510-qzm9wgde	606	17	unique	unique	JJ
cord-336510-qzm9wgde	606	18	region	region	NN
cord-336510-qzm9wgde	606	19	in	in	IN
cord-336510-qzm9wgde	606	20	the	the	DT
cord-336510-qzm9wgde	606	21	genome	genome	NN
cord-336510-qzm9wgde	606	22	of	of	IN
cord-336510-qzm9wgde	606	23	herpes	herpes	NNP
cord-336510-qzm9wgde	606	24	simplex	simplex	NNP
cord-336510-qzm9wgde	606	25	virus	virus	NN
cord-336510-qzm9wgde	606	26	type	type	NN
cord-336510-qzm9wgde	606	27	1	1	CD
cord-336510-qzm9wgde	606	28	Anatomy	Anatomy	NNP
cord-336510-qzm9wgde	606	29	of	of	IN
cord-336510-qzm9wgde	606	30	herpes	herpes	NNP
cord-336510-qzm9wgde	606	31	simplex	simplex	NNP
cord-336510-qzm9wgde	606	32	virus	virus	NN
cord-336510-qzm9wgde	606	33	DNA	dna	NN
cord-336510-qzm9wgde	606	34	:	:	:
cord-336510-qzm9wgde	606	35	strain	strain	VB
cord-336510-qzm9wgde	606	36	differences	difference	NNS
cord-336510-qzm9wgde	606	37	and	and	CC
cord-336510-qzm9wgde	606	38	heterogeneity	heterogeneity	NN
cord-336510-qzm9wgde	606	39	in	in	IN
cord-336510-qzm9wgde	606	40	the	the	DT
cord-336510-qzm9wgde	606	41	locations	location	NNS
cord-336510-qzm9wgde	606	42	of	of	IN
cord-336510-qzm9wgde	606	43	restriction	restriction	NN
cord-336510-qzm9wgde	606	44	endonuclease	endonuclease	NN
cord-336510-qzm9wgde	606	45	cleavage	cleavage	NN
cord-336510-qzm9wgde	606	46	sites	site	NNS
cord-336510-qzm9wgde	606	47	Quantitative	quantitative	JJ
cord-336510-qzm9wgde	606	48	analysis	analysis	NN
cord-336510-qzm9wgde	606	49	of	of	IN
cord-336510-qzm9wgde	606	50	genomic	genomic	JJ
cord-336510-qzm9wgde	606	51	polymorphism	polymorphism	NN
cord-336510-qzm9wgde	606	52	of	of	IN
cord-336510-qzm9wgde	606	53	herpes	herpes	NNP
cord-336510-qzm9wgde	606	54	simplex	simplex	NNP
cord-336510-qzm9wgde	606	55	virus	virus	NN
cord-336510-qzm9wgde	606	56	type	type	NN
cord-336510-qzm9wgde	606	57	1	1	CD
cord-336510-qzm9wgde	606	58	strains	strain	NNS
cord-336510-qzm9wgde	606	59	from	from	IN
cord-336510-qzm9wgde	606	60	six	six	CD
cord-336510-qzm9wgde	606	61	countries	country	NNS
cord-336510-qzm9wgde	606	62	:	:	:
cord-336510-qzm9wgde	606	63	studies	study	NNS
cord-336510-qzm9wgde	606	64	of	of	IN
cord-336510-qzm9wgde	606	65	molecular	molecular	JJ
cord-336510-qzm9wgde	606	66	evolution	evolution	NN
cord-336510-qzm9wgde	606	67	and	and	CC
cord-336510-qzm9wgde	606	68	molecular	molecular	JJ
cord-336510-qzm9wgde	606	69	epidemiology	epidemiology	NN
cord-336510-qzm9wgde	606	70	of	of	IN
cord-336510-qzm9wgde	606	71	the	the	DT
cord-336510-qzm9wgde	606	72	virus	virus	NN
cord-336510-qzm9wgde	606	73	Demonstration	demonstration	NN
cord-336510-qzm9wgde	606	74	of	of	IN
cord-336510-qzm9wgde	606	75	exogenous	exogenous	JJ
cord-336510-qzm9wgde	606	76	genital	genital	JJ
cord-336510-qzm9wgde	606	77	reinfection	reinfection	NN
cord-336510-qzm9wgde	606	78	with	with	IN
cord-336510-qzm9wgde	606	79	herpes	herpes	NN
cord-336510-qzm9wgde	606	80	simplex	simplex	NNP
cord-336510-qzm9wgde	606	81	virus	virus	NN
cord-336510-qzm9wgde	606	82	type	type	NN
cord-336510-qzm9wgde	606	83	2	2	CD
cord-336510-qzm9wgde	606	84	by	by	IN
cord-336510-qzm9wgde	606	85	restriction	restriction	NN
cord-336510-qzm9wgde	606	86	endonuclease	endonuclease	NN
cord-336510-qzm9wgde	606	87	fingerprinting	fingerprinting	NN
cord-336510-qzm9wgde	606	88	of	of	IN
cord-336510-qzm9wgde	606	89	viral	viral	JJ
cord-336510-qzm9wgde	606	90	DNA	dna	NN
cord-336510-qzm9wgde	606	91	Herpes	Herpes	NNP
cord-336510-qzm9wgde	606	92	simplex	simplex	NN
cord-336510-qzm9wgde	606	93	viruses	virus	NNS
cord-336510-qzm9wgde	606	94	and	and	CC
cord-336510-qzm9wgde	606	95	their	-PRON-	PRP$
cord-336510-qzm9wgde	606	96	replication	replication	NN
cord-336510-qzm9wgde	606	97	Monoclonal	Monoclonal	NNP
cord-336510-qzm9wgde	606	98	antibodies	antibody	NNS
cord-336510-qzm9wgde	606	99	define	define	VBP
cord-336510-qzm9wgde	606	100	a	a	DT
cord-336510-qzm9wgde	606	101	domain	domain	NN
cord-336510-qzm9wgde	606	102	on	on	IN
cord-336510-qzm9wgde	606	103	Herpes	Herpes	NNP
cord-336510-qzm9wgde	606	104	Simplex	Simplex	NNP
cord-336510-qzm9wgde	606	105	Virus	Virus	NNP
cord-336510-qzm9wgde	606	106	glycoprotein	glycoprotein	NN
cord-336510-qzm9wgde	606	107	B	b	NN
cord-336510-qzm9wgde	606	108	involved	involve	VBN
cord-336510-qzm9wgde	606	109	in	in	IN
cord-336510-qzm9wgde	606	110	virus	virus	NN
cord-336510-qzm9wgde	606	111	penetration	penetration	NN
cord-336510-qzm9wgde	606	112	Role	role	NN
cord-336510-qzm9wgde	606	113	of	of	IN
cord-336510-qzm9wgde	606	114	glycoprotein	glycoprotein	NN
cord-336510-qzm9wgde	606	115	B	b	NN
cord-336510-qzm9wgde	606	116	of	of	IN
cord-336510-qzm9wgde	606	117	herpes	herpes	NNP
cord-336510-qzm9wgde	606	118	simplex	simplex	NNP
cord-336510-qzm9wgde	606	119	virus	virus	NN
cord-336510-qzm9wgde	606	120	type	type	NN
cord-336510-qzm9wgde	606	121	1	1	CD
cord-336510-qzm9wgde	606	122	in	in	IN
cord-336510-qzm9wgde	606	123	viral	viral	JJ
cord-336510-qzm9wgde	606	124	entry	entry	NN
cord-336510-qzm9wgde	606	125	and	and	CC
cord-336510-qzm9wgde	606	126	cell	cell	NN
cord-336510-qzm9wgde	606	127	fusion	fusion	NN
cord-336510-qzm9wgde	606	128	Neutralizing	neutralize	VBG
cord-336510-qzm9wgde	606	129	monoclonal	monoclonal	JJ
cord-336510-qzm9wgde	606	130	antibodies	antibody	NNS
cord-336510-qzm9wgde	606	131	specific	specific	JJ
cord-336510-qzm9wgde	606	132	for	for	IN
cord-336510-qzm9wgde	606	133	herpes	herpes	NNP
cord-336510-qzm9wgde	606	134	simplex	simplex	NNP
cord-336510-qzm9wgde	606	135	virus	virus	NN
cord-336510-qzm9wgde	606	136	glycoprotein	glycoprotein	NN
cord-336510-qzm9wgde	606	137	D	d	NN
cord-336510-qzm9wgde	606	138	inhibit	inhibit	VBP
cord-336510-qzm9wgde	606	139	virus	virus	NN
cord-336510-qzm9wgde	606	140	penetration	penetration	NN
cord-336510-qzm9wgde	606	141	Seroprevalence	Seroprevalence	NNP
cord-336510-qzm9wgde	606	142	of	of	IN
cord-336510-qzm9wgde	606	143	herpes	herpes	NNP
cord-336510-qzm9wgde	606	144	simplex	simplex	NNP
cord-336510-qzm9wgde	606	145	virus	virus	NN
cord-336510-qzm9wgde	606	146	infections	infection	NNS
cord-336510-qzm9wgde	606	147	in	in	IN
cord-336510-qzm9wgde	606	148	a	a	DT
cord-336510-qzm9wgde	606	149	family	family	NN
cord-336510-qzm9wgde	606	150	medicine	medicine	NN
cord-336510-qzm9wgde	606	151	clinic	clinic	NN
cord-336510-qzm9wgde	606	152	Natural	natural	JJ
cord-336510-qzm9wgde	606	153	history	history	NN
cord-336510-qzm9wgde	606	154	of	of	IN
cord-336510-qzm9wgde	606	155	genital	genital	JJ
cord-336510-qzm9wgde	606	156	herpes	herpes	NN
cord-336510-qzm9wgde	606	157	simplex	simplex	NN
cord-336510-qzm9wgde	606	158	virus	virus	NN
cord-336510-qzm9wgde	606	159	type	type	NN
cord-336510-qzm9wgde	606	160	1	1	CD
cord-336510-qzm9wgde	606	161	infection	infection	NN
cord-336510-qzm9wgde	606	162	Six	six	CD
cord-336510-qzm9wgde	606	163	years	year	NNS
cord-336510-qzm9wgde	606	164	experience	experience	VBP
cord-336510-qzm9wgde	606	165	with	with	IN
cord-336510-qzm9wgde	606	166	herpes	herpes	NNP
cord-336510-qzm9wgde	606	167	simplex	simplex	NNP
cord-336510-qzm9wgde	606	168	virus	virus	NN
cord-336510-qzm9wgde	606	169	in	in	IN
cord-336510-qzm9wgde	606	170	a	a	DT
cord-336510-qzm9wgde	606	171	children	child	NNS
cord-336510-qzm9wgde	606	172	's	's	POS
cord-336510-qzm9wgde	606	173	home	home	NN
cord-336510-qzm9wgde	606	174	Pharyngitis	Pharyngitis	NNP
cord-336510-qzm9wgde	606	175	associated	associate	VBD
cord-336510-qzm9wgde	606	176	with	with	IN
cord-336510-qzm9wgde	606	177	herpes	herpes	NN
cord-336510-qzm9wgde	606	178	simplex	simplex	NNP
cord-336510-qzm9wgde	606	179	virus	virus	NN
cord-336510-qzm9wgde	606	180	in	in	IN
cord-336510-qzm9wgde	606	181	college	college	NN
cord-336510-qzm9wgde	606	182	students	student	NNS
cord-336510-qzm9wgde	607	1	Herpes	Herpes	NNP
cord-336510-qzm9wgde	607	2	simplex	simplex	NN
cord-336510-qzm9wgde	607	3	virus	virus	NN
cord-336510-qzm9wgde	607	4	Use	use	NN
cord-336510-qzm9wgde	607	5	of	of	IN
cord-336510-qzm9wgde	607	6	routine	routine	JJ
cord-336510-qzm9wgde	607	7	viral	viral	JJ
cord-336510-qzm9wgde	607	8	cultures	culture	NNS
cord-336510-qzm9wgde	607	9	at	at	IN
cord-336510-qzm9wgde	607	10	delivery	delivery	NN
cord-336510-qzm9wgde	607	11	to	to	TO
cord-336510-qzm9wgde	607	12	identify	identify	VB
cord-336510-qzm9wgde	607	13	neonates	neonate	NNS
cord-336510-qzm9wgde	607	14	exposed	expose	VBN
cord-336510-qzm9wgde	607	15	to	to	IN
cord-336510-qzm9wgde	607	16	herpes	herpes	NN
cord-336510-qzm9wgde	607	17	simplex	simplex	NNP
cord-336510-qzm9wgde	607	18	virus	virus	NN
cord-336510-qzm9wgde	608	1	Disseminated	disseminate	VBN
cord-336510-qzm9wgde	608	2	herpes	herpes	NN
cord-336510-qzm9wgde	608	3	-	-	HYPH
cord-336510-qzm9wgde	608	4	simplex	simplex	NN
cord-336510-qzm9wgde	608	5	-	-	HYPH
cord-336510-qzm9wgde	608	6	virus	virus	NN
cord-336510-qzm9wgde	608	7	infections	infection	NNS
cord-336510-qzm9wgde	608	8	Disseminated	disseminate	VBD
cord-336510-qzm9wgde	608	9	herpes	herpe	NNS
cord-336510-qzm9wgde	608	10	with	with	IN
cord-336510-qzm9wgde	608	11	hepatoadrenal	hepatoadrenal	JJ
cord-336510-qzm9wgde	608	12	necrosis	necrosis	NN
cord-336510-qzm9wgde	608	13	in	in	IN
cord-336510-qzm9wgde	608	14	an	an	DT
cord-336510-qzm9wgde	608	15	adult	adult	NN
cord-336510-qzm9wgde	608	16	Herpesvirus	Herpesvirus	NNP
cord-336510-qzm9wgde	608	17	hominis	hominis	NN
cord-336510-qzm9wgde	608	18	hepatitis	hepatitis	NN
cord-336510-qzm9wgde	608	19	and	and	CC
cord-336510-qzm9wgde	608	20	disseminated	disseminate	VBD
cord-336510-qzm9wgde	608	21	intravascular	intravascular	JJ
cord-336510-qzm9wgde	608	22	coagulation	coagulation	NN
cord-336510-qzm9wgde	608	23	.	.	.
cord-336510-qzm9wgde	609	1	Occurrence	occurrence	NN
cord-336510-qzm9wgde	609	2	in	in	IN
cord-336510-qzm9wgde	609	3	an	an	DT
cord-336510-qzm9wgde	609	4	adult	adult	NN
cord-336510-qzm9wgde	609	5	with	with	IN
cord-336510-qzm9wgde	609	6	pemphigus	pemphigus	JJ
cord-336510-qzm9wgde	609	7	vulgaris	vulgaris	NN
cord-336510-qzm9wgde	609	8	Herpes	Herpes	NNP
cord-336510-qzm9wgde	609	9	simplex	simplex	NN
cord-336510-qzm9wgde	609	10	virus	virus	NN
cord-336510-qzm9wgde	609	11	infections	infection	NNS
cord-336510-qzm9wgde	609	12	Acute	acute	JJ
cord-336510-qzm9wgde	609	13	hepatitis	hepatitis	NN
cord-336510-qzm9wgde	609	14	due	due	IN
cord-336510-qzm9wgde	609	15	to	to	IN
cord-336510-qzm9wgde	609	16	Herpes	Herpes	NNP
cord-336510-qzm9wgde	609	17	simplex	simplex	NN
cord-336510-qzm9wgde	609	18	virus	virus	NN
cord-336510-qzm9wgde	609	19	in	in	IN
cord-336510-qzm9wgde	609	20	an	an	DT
cord-336510-qzm9wgde	609	21	adult	adult	NN
cord-336510-qzm9wgde	609	22	Disseminated	disseminate	VBN
cord-336510-qzm9wgde	609	23	herpes	herpes	NN
cord-336510-qzm9wgde	609	24	simplex	simplex	NN
cord-336510-qzm9wgde	609	25	in	in	IN
cord-336510-qzm9wgde	609	26	pregnancy	pregnancy	NN
cord-336510-qzm9wgde	609	27	:	:	:
cord-336510-qzm9wgde	609	28	two	two	CD
cord-336510-qzm9wgde	609	29	cases	case	NNS
cord-336510-qzm9wgde	609	30	and	and	CC
cord-336510-qzm9wgde	609	31	a	a	DT
cord-336510-qzm9wgde	609	32	review	review	NN
cord-336510-qzm9wgde	609	33	Herpesvirus	Herpesvirus	NNP
cord-336510-qzm9wgde	609	34	hominis	hominis	NN
cord-336510-qzm9wgde	609	35	type	type	NN
cord-336510-qzm9wgde	609	36	2	2	CD
cord-336510-qzm9wgde	609	37	meningoencephalitis	meningoencephalitis	NN
cord-336510-qzm9wgde	609	38	following	follow	VBG
cord-336510-qzm9wgde	609	39	renal	renal	JJ
cord-336510-qzm9wgde	609	40	transplantation	transplantation	NN
cord-336510-qzm9wgde	610	1	The	the	DT
cord-336510-qzm9wgde	610	2	acquisition	acquisition	NN
cord-336510-qzm9wgde	610	3	of	of	IN
cord-336510-qzm9wgde	610	4	herpes	herpes	NNP
cord-336510-qzm9wgde	610	5	simplex	simplex	NNP
cord-336510-qzm9wgde	610	6	virus	virus	NN
cord-336510-qzm9wgde	610	7	during	during	IN
cord-336510-qzm9wgde	610	8	pregnancy	pregnancy	NN
cord-336510-qzm9wgde	610	9	Neonatal	neonatal	JJ
cord-336510-qzm9wgde	610	10	herpes	herpes	NN
cord-336510-qzm9wgde	610	11	simplex	simplex	NN
cord-336510-qzm9wgde	610	12	virus	virus	NN
cord-336510-qzm9wgde	610	13	infection	infection	NN
cord-336510-qzm9wgde	610	14	in	in	IN
cord-336510-qzm9wgde	610	15	relation	relation	NN
cord-336510-qzm9wgde	610	16	to	to	IN
cord-336510-qzm9wgde	610	17	asymptomatic	asymptomatic	JJ
cord-336510-qzm9wgde	610	18	maternal	maternal	JJ
cord-336510-qzm9wgde	610	19	infection	infection	NN
cord-336510-qzm9wgde	610	20	at	at	IN
cord-336510-qzm9wgde	610	21	the	the	DT
cord-336510-qzm9wgde	610	22	time	time	NN
cord-336510-qzm9wgde	610	23	of	of	IN
cord-336510-qzm9wgde	610	24	labor	labor	NN
cord-336510-qzm9wgde	610	25	Herpes	Herpes	NNP
cord-336510-qzm9wgde	610	26	simplex	simplex	NN
cord-336510-qzm9wgde	610	27	virus	virus	NN
cord-336510-qzm9wgde	610	28	infections	infection	NNS
cord-336510-qzm9wgde	610	29	of	of	IN
cord-336510-qzm9wgde	610	30	women	woman	NNS
cord-336510-qzm9wgde	610	31	and	and	CC
cord-336510-qzm9wgde	610	32	their	-PRON-	PRP$
cord-336510-qzm9wgde	610	33	offspring	offspring	NN
cord-336510-qzm9wgde	610	34	:	:	:
cord-336510-qzm9wgde	610	35	implications	implication	NNS
cord-336510-qzm9wgde	610	36	for	for	IN
cord-336510-qzm9wgde	610	37	a	a	DT
cord-336510-qzm9wgde	610	38	developed	develop	VBN
cord-336510-qzm9wgde	610	39	society	society	NN
cord-336510-qzm9wgde	610	40	Neonatal	neonatal	JJ
cord-336510-qzm9wgde	610	41	herpes	herpes	NN
cord-336510-qzm9wgde	610	42	simplex	simplex	NN
cord-336510-qzm9wgde	610	43	virus	virus	NN
cord-336510-qzm9wgde	610	44	infections	infection	NNS
cord-336510-qzm9wgde	610	45	:	:	:
cord-336510-qzm9wgde	610	46	is	be	VBZ
cord-336510-qzm9wgde	610	47	there	there	EX
cord-336510-qzm9wgde	610	48	a	a	DT
cord-336510-qzm9wgde	610	49	role	role	NN
cord-336510-qzm9wgde	610	50	for	for	IN
cord-336510-qzm9wgde	610	51	immunoglobulin	immunoglobulin	NN
cord-336510-qzm9wgde	610	52	in	in	IN
cord-336510-qzm9wgde	610	53	disease	disease	NN
cord-336510-qzm9wgde	610	54	prevention	prevention	NN
cord-336510-qzm9wgde	610	55	and	and	CC
cord-336510-qzm9wgde	610	56	therapy	therapy	NN
cord-336510-qzm9wgde	610	57	?	?	.
cord-336510-qzm9wgde	611	1	Type	type	NN
cord-336510-qzm9wgde	611	2	-	-	HYPH
cord-336510-qzm9wgde	611	3	specific	specific	JJ
cord-336510-qzm9wgde	611	4	antibody	antibody	NN
cord-336510-qzm9wgde	611	5	to	to	IN
cord-336510-qzm9wgde	611	6	Herpes	Herpes	NNP
cord-336510-qzm9wgde	611	7	Simplex	Simplex	NNP
cord-336510-qzm9wgde	611	8	Virus	Virus	NNP
cord-336510-qzm9wgde	611	9	type	type	NN
cord-336510-qzm9wgde	611	10	2(HSV-2	2(hsv-2	CD
cord-336510-qzm9wgde	611	11	)	)	-RRB-
cord-336510-qzm9wgde	611	12	glycoprotein	glycoprotein	NN
cord-336510-qzm9wgde	611	13	G	g	NN
cord-336510-qzm9wgde	611	14	in	in	IN
cord-336510-qzm9wgde	611	15	pregnant	pregnant	JJ
cord-336510-qzm9wgde	611	16	women	woman	NNS
cord-336510-qzm9wgde	611	17	,	,	,
cord-336510-qzm9wgde	611	18	infants	infant	NNS
cord-336510-qzm9wgde	611	19	exposed	expose	VBN
cord-336510-qzm9wgde	611	20	to	to	IN
cord-336510-qzm9wgde	611	21	maternal	maternal	JJ
cord-336510-qzm9wgde	611	22	HSV-2	hsv-2	JJ
cord-336510-qzm9wgde	611	23	infection	infection	NN
cord-336510-qzm9wgde	611	24	at	at	IN
cord-336510-qzm9wgde	611	25	delivery	delivery	NN
cord-336510-qzm9wgde	611	26	,	,	,
cord-336510-qzm9wgde	611	27	and	and	CC
cord-336510-qzm9wgde	611	28	infants	infant	NNS
cord-336510-qzm9wgde	611	29	with	with	IN
cord-336510-qzm9wgde	611	30	Neonatal	Neonatal	NNP
cord-336510-qzm9wgde	611	31	Herpes	Herpes	NNP
cord-336510-qzm9wgde	611	32	Low	low	JJ
cord-336510-qzm9wgde	611	33	risk	risk	NN
cord-336510-qzm9wgde	611	34	of	of	IN
cord-336510-qzm9wgde	611	35	herpes	herpes	NN
cord-336510-qzm9wgde	611	36	simplex	simplex	NNP
cord-336510-qzm9wgde	611	37	virus	virus	NN
cord-336510-qzm9wgde	611	38	infections	infection	NNS
cord-336510-qzm9wgde	611	39	in	in	IN
cord-336510-qzm9wgde	611	40	neonates	neonate	NNS
cord-336510-qzm9wgde	611	41	exposed	expose	VBN
cord-336510-qzm9wgde	611	42	to	to	IN
cord-336510-qzm9wgde	611	43	the	the	DT
cord-336510-qzm9wgde	611	44	virus	virus	NN
cord-336510-qzm9wgde	611	45	at	at	IN
cord-336510-qzm9wgde	611	46	the	the	DT
cord-336510-qzm9wgde	611	47	time	time	NN
cord-336510-qzm9wgde	611	48	of	of	IN
cord-336510-qzm9wgde	611	49	vaginal	vaginal	JJ
cord-336510-qzm9wgde	611	50	delivery	delivery	NN
cord-336510-qzm9wgde	611	51	to	to	IN
cord-336510-qzm9wgde	611	52	mothers	mother	NNS
cord-336510-qzm9wgde	611	53	with	with	IN
cord-336510-qzm9wgde	611	54	recurrent	recurrent	JJ
cord-336510-qzm9wgde	611	55	genital	genital	JJ
cord-336510-qzm9wgde	611	56	herpes	herpes	NN
cord-336510-qzm9wgde	611	57	simplex	simplex	NN
cord-336510-qzm9wgde	611	58	virus	virus	NN
cord-336510-qzm9wgde	611	59	infections	infection	NNS
cord-336510-qzm9wgde	611	60	Neonatal	neonatal	JJ
cord-336510-qzm9wgde	611	61	herpes	herpe	NNS
cord-336510-qzm9wgde	611	62	simplex	simplex	NN
cord-336510-qzm9wgde	611	63	infection	infection	NN
cord-336510-qzm9wgde	611	64	Safety	safety	NN
cord-336510-qzm9wgde	611	65	and	and	CC
cord-336510-qzm9wgde	611	66	efficacy	efficacy	NN
cord-336510-qzm9wgde	611	67	of	of	IN
cord-336510-qzm9wgde	611	68	highdose	highdose	NNP
cord-336510-qzm9wgde	611	69	intravenous	intravenous	JJ
cord-336510-qzm9wgde	611	70	acyclovir	acyclovir	NNP
cord-336510-qzm9wgde	611	71	in	in	IN
cord-336510-qzm9wgde	611	72	the	the	DT
cord-336510-qzm9wgde	611	73	management	management	NN
cord-336510-qzm9wgde	611	74	of	of	IN
cord-336510-qzm9wgde	611	75	neonatal	neonatal	JJ
cord-336510-qzm9wgde	611	76	herpes	herpes	NN
cord-336510-qzm9wgde	611	77	simplex	simplex	NN
cord-336510-qzm9wgde	611	78	virus	virus	NN
cord-336510-qzm9wgde	611	79	infections	infection	NNS
cord-336510-qzm9wgde	611	80	Natural	natural	JJ
cord-336510-qzm9wgde	611	81	history	history	NN
cord-336510-qzm9wgde	611	82	of	of	IN
cord-336510-qzm9wgde	611	83	neonatal	neonatal	JJ
cord-336510-qzm9wgde	611	84	herpes	herpes	NN
cord-336510-qzm9wgde	611	85	simplex	simplex	NN
cord-336510-qzm9wgde	611	86	virus	virus	NN
cord-336510-qzm9wgde	611	87	infections	infection	NNS
cord-336510-qzm9wgde	611	88	in	in	IN
cord-336510-qzm9wgde	611	89	the	the	DT
cord-336510-qzm9wgde	611	90	acyclovir	acyclovir	NNP
cord-336510-qzm9wgde	611	91	era	era	NN
cord-336510-qzm9wgde	611	92	Advances	advance	VBZ
cord-336510-qzm9wgde	611	93	in	in	IN
cord-336510-qzm9wgde	611	94	the	the	DT
cord-336510-qzm9wgde	611	95	treatment	treatment	NN
cord-336510-qzm9wgde	611	96	of	of	IN
cord-336510-qzm9wgde	611	97	neonatal	neonatal	JJ
cord-336510-qzm9wgde	611	98	herpes	herpes	NN
cord-336510-qzm9wgde	611	99	simplex	simplex	NN
cord-336510-qzm9wgde	611	100	infections	infection	NNS
cord-336510-qzm9wgde	611	101	HSV-2	hsv-2	VBP
cord-336510-qzm9wgde	611	102	replication	replication	NN
cord-336510-qzm9wgde	611	103	sites	site	NNS
cord-336510-qzm9wgde	611	104	,	,	,
cord-336510-qzm9wgde	611	105	monocyte	monocyte	NNP
cord-336510-qzm9wgde	611	106	and	and	CC
cord-336510-qzm9wgde	611	107	lymphocytic	lymphocytic	JJ
cord-336510-qzm9wgde	611	108	cell	cell	NN
cord-336510-qzm9wgde	611	109	infection	infection	NN
cord-336510-qzm9wgde	611	110	and	and	CC
cord-336510-qzm9wgde	611	111	virion	virion	NN
cord-336510-qzm9wgde	611	112	phagocytosis	phagocytosis	NN
cord-336510-qzm9wgde	611	113	by	by	IN
cord-336510-qzm9wgde	611	114	neutrophils	neutrophil	NNS
cord-336510-qzm9wgde	611	115	,	,	,
cord-336510-qzm9wgde	611	116	in	in	IN
cord-336510-qzm9wgde	611	117	vesicular	vesicular	JJ
cord-336510-qzm9wgde	611	118	lesions	lesion	NNS
cord-336510-qzm9wgde	611	119	on	on	IN
cord-336510-qzm9wgde	611	120	penile	penile	JJ
cord-336510-qzm9wgde	611	121	skin	skin	NN
cord-336510-qzm9wgde	611	122	.	.	.
cord-336510-qzm9wgde	612	1	Electronoptical	Electronoptical	NNP
cord-336510-qzm9wgde	612	2	studies	study	NNS
cord-336510-qzm9wgde	612	3	of	of	IN
cord-336510-qzm9wgde	612	4	a	a	DT
cord-336510-qzm9wgde	612	5	biopsy	biopsy	NN
cord-336510-qzm9wgde	612	6	Principles	principle	NNS
cord-336510-qzm9wgde	612	7	and	and	CC
cord-336510-qzm9wgde	612	8	practice	practice	NN
cord-336510-qzm9wgde	612	9	of	of	IN
cord-336510-qzm9wgde	612	10	infectious	infectious	JJ
cord-336510-qzm9wgde	612	11	diseases	disease	NNS
cord-336510-qzm9wgde	612	12	Herpes	Herpes	NNP
cord-336510-qzm9wgde	612	13	simplex	simplex	NN
cord-336510-qzm9wgde	612	14	encephalitis	encephalitis	RB
cord-336510-qzm9wgde	612	15	Cantor	Cantor	NNP
cord-336510-qzm9wgde	612	16	H	H	NNP
cord-336510-qzm9wgde	612	17	:	:	:
cord-336510-qzm9wgde	612	18	T	t	NN
cord-336510-qzm9wgde	612	19	cell	cell	NN
cord-336510-qzm9wgde	612	20	-	-	HYPH
cord-336510-qzm9wgde	612	21	dependent	dependent	JJ
cord-336510-qzm9wgde	612	22	and	and	CC
cord-336510-qzm9wgde	612	23	-independent	-independent	JJ
cord-336510-qzm9wgde	612	24	pathways	pathway	NNS
cord-336510-qzm9wgde	612	25	to	to	TO
cord-336510-qzm9wgde	612	26	tissue	tissue	VB
cord-336510-qzm9wgde	612	27	destruction	destruction	NN
cord-336510-qzm9wgde	612	28	following	follow	VBG
cord-336510-qzm9wgde	612	29	herpes	herpes	NN
cord-336510-qzm9wgde	612	30	simplex	simplex	NN
cord-336510-qzm9wgde	612	31	virus-1	virus-1	NNP
cord-336510-qzm9wgde	612	32	infection	infection	NN
cord-336510-qzm9wgde	612	33	Mice	mouse	NNS
cord-336510-qzm9wgde	612	34	transgenic	transgenic	JJ
cord-336510-qzm9wgde	612	35	for	for	IN
cord-336510-qzm9wgde	612	36	IL-1	IL-1	NNP
cord-336510-qzm9wgde	612	37	receptor	receptor	NNP
cord-336510-qzm9wgde	612	38	antagonist	antagonist	NN
cord-336510-qzm9wgde	612	39	protein	protein	NN
cord-336510-qzm9wgde	612	40	are	be	VBP
cord-336510-qzm9wgde	612	41	resistant	resistant	JJ
cord-336510-qzm9wgde	612	42	to	to	IN
cord-336510-qzm9wgde	612	43	herpetic	herpetic	JJ
cord-336510-qzm9wgde	612	44	stromal	stromal	JJ
cord-336510-qzm9wgde	612	45	keratitis	keratitis	NN
cord-336510-qzm9wgde	612	46	:	:	:
cord-336510-qzm9wgde	612	47	possible	possible	JJ
cord-336510-qzm9wgde	612	48	role	role	NN
cord-336510-qzm9wgde	612	49	for	for	IN
cord-336510-qzm9wgde	612	50	IL-1	IL-1	NNP
cord-336510-qzm9wgde	612	51	in	in	IN
cord-336510-qzm9wgde	612	52	herpetic	herpetic	JJ
cord-336510-qzm9wgde	612	53	stromal	stromal	JJ
cord-336510-qzm9wgde	612	54	keratitis	keratitis	NN
cord-336510-qzm9wgde	612	55	pathogenesis	pathogenesis	NN
cord-336510-qzm9wgde	612	56	Molecular	molecular	JJ
cord-336510-qzm9wgde	612	57	mimicry	mimicry	NN
cord-336510-qzm9wgde	612	58	by	by	IN
cord-336510-qzm9wgde	612	59	herpes	herpes	NN
cord-336510-qzm9wgde	612	60	simplex	simplex	NNP
cord-336510-qzm9wgde	612	61	virus	virus	NN
cord-336510-qzm9wgde	612	62	-	-	HYPH
cord-336510-qzm9wgde	612	63	type	type	NN
cord-336510-qzm9wgde	612	64	1	1	CD
cord-336510-qzm9wgde	612	65	:	:	:
cord-336510-qzm9wgde	612	66	autoimmune	autoimmune	JJ
cord-336510-qzm9wgde	612	67	disease	disease	NN
cord-336510-qzm9wgde	612	68	after	after	IN
cord-336510-qzm9wgde	612	69	viral	viral	JJ
cord-336510-qzm9wgde	612	70	infection	infection	NN
cord-336510-qzm9wgde	612	71	A	a	DT
cord-336510-qzm9wgde	612	72	role	role	NN
cord-336510-qzm9wgde	612	73	for	for	IN
cord-336510-qzm9wgde	612	74	transforming	transform	VBG
cord-336510-qzm9wgde	612	75	growth	growth	NN
cord-336510-qzm9wgde	612	76	factor	factor	NN
cord-336510-qzm9wgde	612	77	-	-	HYPH
cord-336510-qzm9wgde	612	78	beta1	beta1	NN
cord-336510-qzm9wgde	612	79	in	in	IN
cord-336510-qzm9wgde	612	80	the	the	DT
cord-336510-qzm9wgde	612	81	increased	increase	VBN
cord-336510-qzm9wgde	612	82	pneumonitis	pneumonitis	NN
cord-336510-qzm9wgde	612	83	in	in	IN
cord-336510-qzm9wgde	612	84	murine	murine	JJ
cord-336510-qzm9wgde	612	85	allogeneic	allogeneic	IN
cord-336510-qzm9wgde	612	86	bone	bone	NN
cord-336510-qzm9wgde	612	87	marrow	marrow	NN
cord-336510-qzm9wgde	612	88	transplant	transplant	NN
cord-336510-qzm9wgde	612	89	recipients	recipient	NNS
cord-336510-qzm9wgde	612	90	with	with	IN
cord-336510-qzm9wgde	612	91	graft	graft	NN
cord-336510-qzm9wgde	612	92	-	-	HYPH
cord-336510-qzm9wgde	612	93	versus	versus	IN
cord-336510-qzm9wgde	612	94	-	-	HYPH
cord-336510-qzm9wgde	612	95	host	host	NN
cord-336510-qzm9wgde	612	96	disease	disease	NN
cord-336510-qzm9wgde	612	97	after	after	IN
cord-336510-qzm9wgde	612	98	pulmonary	pulmonary	JJ
cord-336510-qzm9wgde	612	99	herpes	herpes	NN
cord-336510-qzm9wgde	612	100	simplex	simplex	NN
cord-336510-qzm9wgde	612	101	virus	virus	NN
cord-336510-qzm9wgde	612	102	type	type	NN
cord-336510-qzm9wgde	612	103	1	1	CD
cord-336510-qzm9wgde	612	104	infection	infection	NN
cord-336510-qzm9wgde	612	105	Herpes	Herpes	NNP
cord-336510-qzm9wgde	612	106	simplex	simplex	NN
cord-336510-qzm9wgde	612	107	virus	virus	NN
cord-336510-qzm9wgde	612	108	1	1	CD
cord-336510-qzm9wgde	612	109	interaction	interaction	NN
cord-336510-qzm9wgde	612	110	with	with	IN
cord-336510-qzm9wgde	612	111	Toll	Toll	NNP
cord-336510-qzm9wgde	612	112	-	-	HYPH
cord-336510-qzm9wgde	612	113	like	like	JJ
cord-336510-qzm9wgde	612	114	receptor	receptor	NN
cord-336510-qzm9wgde	612	115	2	2	CD
cord-336510-qzm9wgde	612	116	contributes	contribute	VBZ
cord-336510-qzm9wgde	612	117	to	to	IN
cord-336510-qzm9wgde	612	118	lethal	lethal	JJ
cord-336510-qzm9wgde	612	119	encephalitis	encephalitis	JJ
cord-336510-qzm9wgde	612	120	Suppression	suppression	NN
cord-336510-qzm9wgde	612	121	of	of	IN
cord-336510-qzm9wgde	612	122	herpes	herpes	NNP
cord-336510-qzm9wgde	612	123	simplex	simplex	NNP
cord-336510-qzm9wgde	612	124	virus	virus	NN
cord-336510-qzm9wgde	612	125	type	type	NN
cord-336510-qzm9wgde	612	126	1	1	CD
cord-336510-qzm9wgde	612	127	(	(	-LRB-
cord-336510-qzm9wgde	612	128	HSV-1)-induced	hsv-1)-induced	JJ
cord-336510-qzm9wgde	612	129	pneumonia	pneumonia	NN
cord-336510-qzm9wgde	612	130	in	in	IN
cord-336510-qzm9wgde	612	131	mice	mouse	NNS
cord-336510-qzm9wgde	612	132	by	by	IN
cord-336510-qzm9wgde	612	133	inhibition	inhibition	NN
cord-336510-qzm9wgde	612	134	of	of	IN
cord-336510-qzm9wgde	612	135	inducible	inducible	JJ
cord-336510-qzm9wgde	612	136	nitric	nitric	NN
cord-336510-qzm9wgde	612	137	oxide	oxide	NN
cord-336510-qzm9wgde	612	138	synthase	synthase	NN
cord-336510-qzm9wgde	612	139	(	(	-LRB-
cord-336510-qzm9wgde	612	140	iNOS	iNOS	''
cord-336510-qzm9wgde	612	141	,	,	,
cord-336510-qzm9wgde	612	142	NOS2	NOS2	NNP
cord-336510-qzm9wgde	612	143	)	)	-RRB-
cord-336510-qzm9wgde	612	144	Evaluation	Evaluation	NNP
cord-336510-qzm9wgde	612	145	of	of	IN
cord-336510-qzm9wgde	612	146	systemic	systemic	JJ
cord-336510-qzm9wgde	612	147	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	612	148	responses	response	NNS
cord-336510-qzm9wgde	612	149	in	in	IN
cord-336510-qzm9wgde	612	150	neonates	neonate	NNS
cord-336510-qzm9wgde	612	151	with	with	IN
cord-336510-qzm9wgde	612	152	herpes	herpes	NN
cord-336510-qzm9wgde	612	153	simplex	simplex	NNP
cord-336510-qzm9wgde	612	154	virus	virus	NN
cord-336510-qzm9wgde	612	155	infection	infection	NN
cord-336510-qzm9wgde	612	156	Lecons	Lecons	NNP
cord-336510-qzm9wgde	612	157	sur	sur	FW
cord-336510-qzm9wgde	612	158	la	la	FW
cord-336510-qzm9wgde	612	159	pathologie	pathologie	NNP
cord-336510-qzm9wgde	612	160	comparée	comparée	NNP
cord-336510-qzm9wgde	612	161	de	de	IN
cord-336510-qzm9wgde	612	162	l'inflammation	l'inflammation	NNP
cord-336510-qzm9wgde	612	163	Das	Das	NNP
cord-336510-qzm9wgde	612	164	reticulo	reticulo	NN
cord-336510-qzm9wgde	612	165	-	-	HYPH
cord-336510-qzm9wgde	612	166	endotheliale	endotheliale	JJ
cord-336510-qzm9wgde	612	167	system	system	NN
cord-336510-qzm9wgde	613	1	The	the	DT
cord-336510-qzm9wgde	613	2	mononuclear	mononuclear	JJ
cord-336510-qzm9wgde	613	3	phagocyte	phagocyte	NNP
cord-336510-qzm9wgde	613	4	system	system	NN
cord-336510-qzm9wgde	613	5	:	:	:
cord-336510-qzm9wgde	613	6	a	a	DT
cord-336510-qzm9wgde	613	7	new	new	JJ
cord-336510-qzm9wgde	613	8	classification	classification	NN
cord-336510-qzm9wgde	613	9	of	of	IN
cord-336510-qzm9wgde	613	10	macrophages	macrophage	NNS
cord-336510-qzm9wgde	613	11	,	,	,
cord-336510-qzm9wgde	613	12	monocytes	monocyte	NNS
cord-336510-qzm9wgde	613	13	,	,	,
cord-336510-qzm9wgde	613	14	and	and	CC
cord-336510-qzm9wgde	613	15	their	-PRON-	PRP$
cord-336510-qzm9wgde	613	16	precursor	precursor	NN
cord-336510-qzm9wgde	613	17	cells	cell	NNS
cord-336510-qzm9wgde	614	1	The	the	DT
cord-336510-qzm9wgde	614	2	origin	origin	NN
cord-336510-qzm9wgde	614	3	and	and	CC
cord-336510-qzm9wgde	614	4	kinetics	kinetic	NNS
cord-336510-qzm9wgde	614	5	of	of	IN
cord-336510-qzm9wgde	614	6	mononuclear	mononuclear	NN
cord-336510-qzm9wgde	614	7	phagocytes	phagocyte	NNS
cord-336510-qzm9wgde	614	8	Functional	functional	JJ
cord-336510-qzm9wgde	614	9	heterogeneity	heterogeneity	NN
cord-336510-qzm9wgde	614	10	in	in	IN
cord-336510-qzm9wgde	614	11	liver	liver	NN
cord-336510-qzm9wgde	614	12	and	and	CC
cord-336510-qzm9wgde	614	13	lung	lung	NN
cord-336510-qzm9wgde	614	14	macrophages	macrophage	NNS
cord-336510-qzm9wgde	615	1	A	a	DT
cord-336510-qzm9wgde	615	2	quantitative	quantitative	JJ
cord-336510-qzm9wgde	615	3	study	study	NN
cord-336510-qzm9wgde	615	4	of	of	IN
cord-336510-qzm9wgde	615	5	the	the	DT
cord-336510-qzm9wgde	615	6	kinetics	kinetic	NNS
cord-336510-qzm9wgde	615	7	of	of	IN
cord-336510-qzm9wgde	615	8	blood	blood	NN
cord-336510-qzm9wgde	615	9	clearance	clearance	NN
cord-336510-qzm9wgde	615	10	of	of	IN
cord-336510-qzm9wgde	615	11	P32-labelled	P32-labelled	NNP
cord-336510-qzm9wgde	615	12	Escherichia	Escherichia	NNP
cord-336510-qzm9wgde	615	13	coli	coli	NNS
cord-336510-qzm9wgde	615	14	and	and	CC
cord-336510-qzm9wgde	615	15	Staphylococci	Staphylococci	NNP
cord-336510-qzm9wgde	615	16	by	by	IN
cord-336510-qzm9wgde	615	17	the	the	DT
cord-336510-qzm9wgde	615	18	reticuloendothelial	reticuloendothelial	JJ
cord-336510-qzm9wgde	615	19	system	system	NN
cord-336510-qzm9wgde	615	20	Blood	blood	NN
cord-336510-qzm9wgde	615	21	clearance	clearance	NN
cord-336510-qzm9wgde	615	22	of	of	IN
cord-336510-qzm9wgde	615	23	P32-labeled	P32-labeled	NNP
cord-336510-qzm9wgde	615	24	vesicular	vesicular	JJ
cord-336510-qzm9wgde	615	25	stomatitis	stomatitis	NN
cord-336510-qzm9wgde	615	26	and	and	CC
cord-336510-qzm9wgde	615	27	Newcastle	Newcastle	NNP
cord-336510-qzm9wgde	615	28	disease	disease	NN
cord-336510-qzm9wgde	615	29	viruses	virus	NNS
cord-336510-qzm9wgde	615	30	by	by	IN
cord-336510-qzm9wgde	615	31	the	the	DT
cord-336510-qzm9wgde	615	32	reticuloendothelial	reticuloendothelial	JJ
cord-336510-qzm9wgde	615	33	system	system	NN
cord-336510-qzm9wgde	615	34	in	in	IN
cord-336510-qzm9wgde	615	35	mice	mouse	NNS
cord-336510-qzm9wgde	615	36	Murine	Murine	NNP
cord-336510-qzm9wgde	615	37	Kupffer	Kupffer	NNP
cord-336510-qzm9wgde	615	38	cells	cell	NNS
cord-336510-qzm9wgde	615	39	.	.	.
cord-336510-qzm9wgde	616	1	Mononuclear	Mononuclear	NNP
cord-336510-qzm9wgde	616	2	phagocytes	phagocyte	NNS
cord-336510-qzm9wgde	616	3	deficient	deficient	JJ
cord-336510-qzm9wgde	616	4	in	in	IN
cord-336510-qzm9wgde	616	5	the	the	DT
cord-336510-qzm9wgde	616	6	generation	generation	NN
cord-336510-qzm9wgde	616	7	of	of	IN
cord-336510-qzm9wgde	616	8	reactive	reactive	JJ
cord-336510-qzm9wgde	616	9	oxygen	oxygen	NN
cord-336510-qzm9wgde	616	10	intermediates	intermediate	NNS
cord-336510-qzm9wgde	616	11	Macrophage	Macrophage	NNP
cord-336510-qzm9wgde	616	12	plasma	plasma	NN
cord-336510-qzm9wgde	616	13	membrane	membrane	NN
cord-336510-qzm9wgde	616	14	and	and	CC
cord-336510-qzm9wgde	616	15	secretory	secretory	JJ
cord-336510-qzm9wgde	616	16	properties	property	NNS
cord-336510-qzm9wgde	616	17	in	in	IN
cord-336510-qzm9wgde	616	18	murine	murine	JJ
cord-336510-qzm9wgde	616	19	malaria	malaria	NN
cord-336510-qzm9wgde	616	20	.	.	.
cord-336510-qzm9wgde	617	1	Effects	effect	NNS
cord-336510-qzm9wgde	617	2	of	of	IN
cord-336510-qzm9wgde	617	3	Plasmodium	Plasmodium	NNP
cord-336510-qzm9wgde	617	4	yoelii	yoelii	VBP
cord-336510-qzm9wgde	617	5	blood	blood	NN
cord-336510-qzm9wgde	617	6	-	-	HYPH
cord-336510-qzm9wgde	617	7	stage	stage	NN
cord-336510-qzm9wgde	617	8	infection	infection	NN
cord-336510-qzm9wgde	617	9	on	on	IN
cord-336510-qzm9wgde	617	10	macrophages	macrophage	NNS
cord-336510-qzm9wgde	617	11	in	in	IN
cord-336510-qzm9wgde	617	12	liver	liver	NN
cord-336510-qzm9wgde	617	13	,	,	,
cord-336510-qzm9wgde	617	14	spleen	spleen	NNS
cord-336510-qzm9wgde	617	15	,	,	,
cord-336510-qzm9wgde	617	16	and	and	CC
cord-336510-qzm9wgde	617	17	blood	blood	NN
cord-336510-qzm9wgde	617	18	Microglia	Microglia	NNP
cord-336510-qzm9wgde	617	19	,	,	,
cord-336510-qzm9wgde	617	20	macrophages	macrophage	NNS
cord-336510-qzm9wgde	617	21	,	,	,
cord-336510-qzm9wgde	617	22	perivascular	perivascular	NNP
cord-336510-qzm9wgde	617	23	macrophages	macrophage	NNS
cord-336510-qzm9wgde	617	24	,	,	,
cord-336510-qzm9wgde	617	25	and	and	CC
cord-336510-qzm9wgde	617	26	pericytes	pericytes	NNPS
cord-336510-qzm9wgde	617	27	:	:	:
cord-336510-qzm9wgde	617	28	a	a	DT
cord-336510-qzm9wgde	617	29	review	review	NN
cord-336510-qzm9wgde	617	30	of	of	IN
cord-336510-qzm9wgde	617	31	function	function	NN
cord-336510-qzm9wgde	617	32	and	and	CC
cord-336510-qzm9wgde	617	33	identification	identification	NN
cord-336510-qzm9wgde	617	34	Functional	functional	JJ
cord-336510-qzm9wgde	617	35	plasticity	plasticity	NN
cord-336510-qzm9wgde	617	36	of	of	IN
cord-336510-qzm9wgde	617	37	macrophages	macrophage	NNS
cord-336510-qzm9wgde	617	38	:	:	:
cord-336510-qzm9wgde	617	39	reversible	reversible	JJ
cord-336510-qzm9wgde	617	40	adaptation	adaptation	NN
cord-336510-qzm9wgde	617	41	to	to	IN
cord-336510-qzm9wgde	617	42	changing	change	VBG
cord-336510-qzm9wgde	617	43	microenvironments	microenvironment	NNS
cord-336510-qzm9wgde	617	44	Human	human	JJ
cord-336510-qzm9wgde	617	45	monocytes	monocyte	NNS
cord-336510-qzm9wgde	617	46	/	/	SYM
cord-336510-qzm9wgde	617	47	macrophages	macrophage	NNS
cord-336510-qzm9wgde	617	48	:	:	:
cord-336510-qzm9wgde	618	1	NO	no	UH
cord-336510-qzm9wgde	618	2	or	or	CC
cord-336510-qzm9wgde	618	3	no	no	UH
cord-336510-qzm9wgde	618	4	NO	no	NN
cord-336510-qzm9wgde	618	5	?	?	.
cord-336510-qzm9wgde	619	1	Nitric	nitric	NN
cord-336510-qzm9wgde	619	2	oxide	oxide	NN
cord-336510-qzm9wgde	619	3	and	and	CC
cord-336510-qzm9wgde	619	4	macrophage	macrophage	NN
cord-336510-qzm9wgde	619	5	function	function	NN
cord-336510-qzm9wgde	620	1	The	the	DT
cord-336510-qzm9wgde	620	2	origin	origin	NN
cord-336510-qzm9wgde	620	3	,	,	,
cord-336510-qzm9wgde	620	4	kinetics	kinetic	NNS
cord-336510-qzm9wgde	620	5	,	,	,
cord-336510-qzm9wgde	620	6	and	and	CC
cord-336510-qzm9wgde	620	7	characteristics	characteristic	NNS
cord-336510-qzm9wgde	620	8	of	of	IN
cord-336510-qzm9wgde	620	9	the	the	DT
cord-336510-qzm9wgde	620	10	Kupffer	Kupffer	NNP
cord-336510-qzm9wgde	620	11	cells	cell	NNS
cord-336510-qzm9wgde	620	12	in	in	IN
cord-336510-qzm9wgde	620	13	the	the	DT
cord-336510-qzm9wgde	620	14	normal	normal	JJ
cord-336510-qzm9wgde	620	15	steady	steady	JJ
cord-336510-qzm9wgde	620	16	state	state	NN
cord-336510-qzm9wgde	620	17	R	r	NN
cord-336510-qzm9wgde	620	18	:	:	:
cord-336510-qzm9wgde	620	19	Origin	Origin	NNP
cord-336510-qzm9wgde	620	20	,	,	,
cord-336510-qzm9wgde	620	21	Kinetics	Kinetics	NNP
cord-336510-qzm9wgde	620	22	,	,	,
cord-336510-qzm9wgde	620	23	and	and	CC
cord-336510-qzm9wgde	620	24	characteristics	characteristic	NNS
cord-336510-qzm9wgde	620	25	of	of	IN
cord-336510-qzm9wgde	620	26	pulmonary	pulmonary	JJ
cord-336510-qzm9wgde	620	27	macrophages	macrophage	NNS
cord-336510-qzm9wgde	620	28	in	in	IN
cord-336510-qzm9wgde	620	29	the	the	DT
cord-336510-qzm9wgde	620	30	normal	normal	JJ
cord-336510-qzm9wgde	620	31	steady	steady	JJ
cord-336510-qzm9wgde	620	32	state	state	NN
cord-336510-qzm9wgde	620	33	Diesselhoff	Diesselhoff	NNP
cord-336510-qzm9wgde	620	34	-	-	HYPH
cord-336510-qzm9wgde	620	35	den	den	NNP
cord-336510-qzm9wgde	620	36	Dulk	Dulk	NNP
cord-336510-qzm9wgde	620	37	MM	MM	NNP
cord-336510-qzm9wgde	620	38	:	:	:
cord-336510-qzm9wgde	620	39	Dual	dual	JJ
cord-336510-qzm9wgde	620	40	origin	origin	NN
cord-336510-qzm9wgde	620	41	of	of	IN
cord-336510-qzm9wgde	620	42	mouse	mouse	NN
cord-336510-qzm9wgde	620	43	spleen	spleen	NNS
cord-336510-qzm9wgde	620	44	macrophages	macrophage	NNS
cord-336510-qzm9wgde	621	1	A	a	DT
cord-336510-qzm9wgde	621	2	quantitative	quantitative	JJ
cord-336510-qzm9wgde	621	3	evaluation	evaluation	NN
cord-336510-qzm9wgde	621	4	of	of	IN
cord-336510-qzm9wgde	621	5	pulmonary	pulmonary	JJ
cord-336510-qzm9wgde	621	6	macrophage	macrophage	NN
cord-336510-qzm9wgde	621	7	kinetics	kinetic	NNS
cord-336510-qzm9wgde	621	8	Langerhans	Langerhans	NNP
cord-336510-qzm9wgde	621	9	cells	cell	NNS
cord-336510-qzm9wgde	621	10	renew	renew	VBP
cord-336510-qzm9wgde	621	11	in	in	IN
cord-336510-qzm9wgde	621	12	the	the	DT
cord-336510-qzm9wgde	621	13	skin	skin	NN
cord-336510-qzm9wgde	621	14	throughout	throughout	IN
cord-336510-qzm9wgde	621	15	life	life	NN
cord-336510-qzm9wgde	621	16	under	under	IN
cord-336510-qzm9wgde	621	17	steady	steady	JJ
cord-336510-qzm9wgde	621	18	-	-	HYPH
cord-336510-qzm9wgde	621	19	state	state	NN
cord-336510-qzm9wgde	621	20	conditions	condition	NNS
cord-336510-qzm9wgde	622	1	Quantitative	quantitative	JJ
cord-336510-qzm9wgde	622	2	study	study	NN
cord-336510-qzm9wgde	622	3	on	on	IN
cord-336510-qzm9wgde	622	4	the	the	DT
cord-336510-qzm9wgde	622	5	production	production	NN
cord-336510-qzm9wgde	622	6	and	and	CC
cord-336510-qzm9wgde	622	7	kinetics	kinetic	NNS
cord-336510-qzm9wgde	622	8	of	of	IN
cord-336510-qzm9wgde	622	9	mononuclear	mononuclear	JJ
cord-336510-qzm9wgde	622	10	phagocytes	phagocyte	NNS
cord-336510-qzm9wgde	622	11	during	during	IN
cord-336510-qzm9wgde	622	12	an	an	DT
cord-336510-qzm9wgde	622	13	acute	acute	JJ
cord-336510-qzm9wgde	622	14	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	622	15	reaction	reaction	NN
cord-336510-qzm9wgde	622	16	Cellular	cellular	JJ
cord-336510-qzm9wgde	622	17	resistance	resistance	NN
cord-336510-qzm9wgde	622	18	to	to	IN
cord-336510-qzm9wgde	622	19	infection	infection	NN
cord-336510-qzm9wgde	622	20	Host	host	NN
cord-336510-qzm9wgde	622	21	-	-	HYPH
cord-336510-qzm9wgde	622	22	parasite	parasite	NN
cord-336510-qzm9wgde	622	23	relations	relation	NNS
cord-336510-qzm9wgde	622	24	in	in	IN
cord-336510-qzm9wgde	622	25	mouse	mouse	NN
cord-336510-qzm9wgde	622	26	typhoid	typhoid	NN
cord-336510-qzm9wgde	622	27	Suppression	suppression	NN
cord-336510-qzm9wgde	622	28	of	of	IN
cord-336510-qzm9wgde	622	29	macrophages	macrophage	NNS
cord-336510-qzm9wgde	622	30	antimicrobial	antimicrobial	JJ
cord-336510-qzm9wgde	622	31	activity	activity	NN
cord-336510-qzm9wgde	622	32	by	by	IN
cord-336510-qzm9wgde	622	33	a	a	DT
cord-336510-qzm9wgde	622	34	tumor	tumor	NN
cord-336510-qzm9wgde	622	35	cell	cell	NN
cord-336510-qzm9wgde	622	36	product	product	NN
cord-336510-qzm9wgde	622	37	Infections	infection	NNS
cord-336510-qzm9wgde	622	38	in	in	IN
cord-336510-qzm9wgde	622	39	patients	patient	NNS
cord-336510-qzm9wgde	622	40	with	with	IN
cord-336510-qzm9wgde	622	41	inherited	inherit	VBN
cord-336510-qzm9wgde	622	42	defects	defect	NNS
cord-336510-qzm9wgde	622	43	in	in	IN
cord-336510-qzm9wgde	622	44	phagocytic	phagocytic	JJ
cord-336510-qzm9wgde	622	45	function	function	NN
cord-336510-qzm9wgde	622	46	Studies	study	NNS
cord-336510-qzm9wgde	622	47	on	on	IN
cord-336510-qzm9wgde	622	48	the	the	DT
cord-336510-qzm9wgde	622	49	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	622	50	of	of	IN
cord-336510-qzm9wgde	622	51	macrophage	macrophage	NN
cord-336510-qzm9wgde	622	52	activation	activation	NN
cord-336510-qzm9wgde	622	53	.	.	.
cord-336510-qzm9wgde	623	1	I.	I.	NNP
cord-336510-qzm9wgde	623	2	Destruction	destruction	NN
cord-336510-qzm9wgde	623	3	of	of	IN
cord-336510-qzm9wgde	623	4	intracellular	intracellular	JJ
cord-336510-qzm9wgde	623	5	Leishmania	Leishmania	NNP
cord-336510-qzm9wgde	623	6	enriettii	enriettii	NNP
cord-336510-qzm9wgde	623	7	in	in	IN
cord-336510-qzm9wgde	623	8	macrophages	macrophage	NNS
cord-336510-qzm9wgde	623	9	activated	activate	VBN
cord-336510-qzm9wgde	623	10	by	by	IN
cord-336510-qzm9wgde	623	11	cocultivation	cocultivation	NN
cord-336510-qzm9wgde	623	12	with	with	IN
cord-336510-qzm9wgde	623	13	stimulated	stimulate	VBN
cord-336510-qzm9wgde	623	14	lymphocytes	lymphocyte	NNS
cord-336510-qzm9wgde	623	15	Macrophage	Macrophage	NNP
cord-336510-qzm9wgde	623	16	activation	activation	NN
cord-336510-qzm9wgde	623	17	and	and	CC
cord-336510-qzm9wgde	623	18	differentiation	differentiation	NN
cord-336510-qzm9wgde	623	19	Tumor	tumor	NN
cord-336510-qzm9wgde	623	20	necrosis	necrosis	NN
cord-336510-qzm9wgde	623	21	factor	factor	NN
cord-336510-qzm9wgde	623	22	and	and	CC
cord-336510-qzm9wgde	623	23	granulocyte	granulocyte	NN
cord-336510-qzm9wgde	623	24	macrophage	macrophage	NN
cord-336510-qzm9wgde	623	25	-	-	HYPH
cord-336510-qzm9wgde	623	26	colony	colony	NN
cord-336510-qzm9wgde	623	27	stimulating	stimulate	VBG
cord-336510-qzm9wgde	623	28	factor	factor	NN
cord-336510-qzm9wgde	623	29	stimulate	stimulate	VBP
cord-336510-qzm9wgde	623	30	human	human	JJ
cord-336510-qzm9wgde	623	31	macrophages	macrophage	NNS
cord-336510-qzm9wgde	623	32	to	to	TO
cord-336510-qzm9wgde	623	33	restrict	restrict	VB
cord-336510-qzm9wgde	623	34	growth	growth	NN
cord-336510-qzm9wgde	623	35	of	of	IN
cord-336510-qzm9wgde	623	36	virulent	virulent	JJ
cord-336510-qzm9wgde	623	37	Mycobacterium	Mycobacterium	NNP
cord-336510-qzm9wgde	623	38	avium	avium	NN
cord-336510-qzm9wgde	623	39	and	and	CC
cord-336510-qzm9wgde	623	40	to	to	TO
cord-336510-qzm9wgde	623	41	kill	kill	VB
cord-336510-qzm9wgde	623	42	avirulent	avirulent	NN
cord-336510-qzm9wgde	623	43	M.	M.	NNP
cord-336510-qzm9wgde	623	44	avium	avium	NN
cord-336510-qzm9wgde	623	45	:	:	:
cord-336510-qzm9wgde	623	46	killing	kill	VBG
cord-336510-qzm9wgde	623	47	effector	effector	NN
cord-336510-qzm9wgde	623	48	mechanism	mechanism	NN
cord-336510-qzm9wgde	623	49	depends	depend	VBZ
cord-336510-qzm9wgde	623	50	on	on	IN
cord-336510-qzm9wgde	623	51	the	the	DT
cord-336510-qzm9wgde	623	52	generation	generation	NN
cord-336510-qzm9wgde	623	53	of	of	IN
cord-336510-qzm9wgde	623	54	reactive	reactive	JJ
cord-336510-qzm9wgde	623	55	nitrogen	nitrogen	NN
cord-336510-qzm9wgde	623	56	intermediates	intermediate	NNS
cord-336510-qzm9wgde	623	57	Hydrogen	Hydrogen	NNP
cord-336510-qzm9wgde	623	58	peroxide	peroxide	NN
cord-336510-qzm9wgde	623	59	from	from	IN
cord-336510-qzm9wgde	623	60	mouse	mouse	NN
cord-336510-qzm9wgde	623	61	peritoneal	peritoneal	JJ
cord-336510-qzm9wgde	623	62	macrophages	macrophage	NNS
cord-336510-qzm9wgde	623	63	NADPH	NADPH	NNP
cord-336510-qzm9wgde	623	64	oxidase	oxidase	NN
cord-336510-qzm9wgde	623	65	,	,	,
cord-336510-qzm9wgde	623	66	Nramp1	Nramp1	NNP
cord-336510-qzm9wgde	623	67	and	and	CC
cord-336510-qzm9wgde	623	68	nitric	nitric	JJ
cord-336510-qzm9wgde	623	69	oxide	oxide	NN
cord-336510-qzm9wgde	623	70	synthase	synthase	NN
cord-336510-qzm9wgde	623	71	2	2	CD
cord-336510-qzm9wgde	623	72	in	in	IN
cord-336510-qzm9wgde	623	73	the	the	DT
cord-336510-qzm9wgde	623	74	host	host	NN
cord-336510-qzm9wgde	623	75	antimicrobial	antimicrobial	JJ
cord-336510-qzm9wgde	623	76	response	response	NN
cord-336510-qzm9wgde	624	1	In	in	IN
cord-336510-qzm9wgde	624	2	vitro	vitro	FW
cord-336510-qzm9wgde	624	3	studies	study	NNS
cord-336510-qzm9wgde	624	4	on	on	IN
cord-336510-qzm9wgde	624	5	normal	normal	JJ
cord-336510-qzm9wgde	624	6	,	,	,
cord-336510-qzm9wgde	624	7	stimulated	stimulated	JJ
cord-336510-qzm9wgde	624	8	and	and	CC
cord-336510-qzm9wgde	624	9	immunologically	immunologically	RB
cord-336510-qzm9wgde	624	10	activated	activate	VBN
cord-336510-qzm9wgde	624	11	mouse	mouse	NN
cord-336510-qzm9wgde	624	12	macrophages	macrophage	NNS
cord-336510-qzm9wgde	624	13	.	.	.
cord-336510-qzm9wgde	625	1	III	III	NNP
cord-336510-qzm9wgde	625	2	.	.	.
cord-336510-qzm9wgde	626	1	Intracellular	intracellular	JJ
cord-336510-qzm9wgde	626	2	multiplication	multiplication	NN
cord-336510-qzm9wgde	626	3	of	of	IN
cord-336510-qzm9wgde	626	4	Listeria	Listeria	NNP
cord-336510-qzm9wgde	626	5	monocytogenes	monocytogenes	NNP
cord-336510-qzm9wgde	626	6	The	the	DT
cord-336510-qzm9wgde	626	7	chemokine	chemokine	NN
cord-336510-qzm9wgde	626	8	system	system	NN
cord-336510-qzm9wgde	626	9	in	in	IN
cord-336510-qzm9wgde	626	10	diverse	diverse	JJ
cord-336510-qzm9wgde	626	11	forms	form	NNS
cord-336510-qzm9wgde	626	12	of	of	IN
cord-336510-qzm9wgde	626	13	macrophage	macrophage	NN
cord-336510-qzm9wgde	626	14	activation	activation	NN
cord-336510-qzm9wgde	626	15	and	and	CC
cord-336510-qzm9wgde	626	16	polarization	polarization	NN
cord-336510-qzm9wgde	626	17	Differences	difference	NNS
cord-336510-qzm9wgde	626	18	in	in	IN
cord-336510-qzm9wgde	626	19	the	the	DT
cord-336510-qzm9wgde	626	20	response	response	NN
cord-336510-qzm9wgde	626	21	of	of	IN
cord-336510-qzm9wgde	626	22	inbred	inbred	JJ
cord-336510-qzm9wgde	626	23	mouse	mouse	NN
cord-336510-qzm9wgde	626	24	strains	strain	NNS
cord-336510-qzm9wgde	626	25	to	to	IN
cord-336510-qzm9wgde	626	26	the	the	DT
cord-336510-qzm9wgde	626	27	factor	factor	NN
cord-336510-qzm9wgde	626	28	increasing	increase	VBG
cord-336510-qzm9wgde	626	29	monocytopoiesis	monocytopoiesis	NN
cord-336510-qzm9wgde	626	30	X	x	NN
cord-336510-qzm9wgde	626	31	-	-	NN
cord-336510-qzm9wgde	626	32	linkage	linkage	NN
cord-336510-qzm9wgde	626	33	of	of	IN
cord-336510-qzm9wgde	626	34	the	the	DT
cord-336510-qzm9wgde	626	35	early	early	JJ
cord-336510-qzm9wgde	626	36	in	in	IN
cord-336510-qzm9wgde	626	37	vitro	vitro	FW
cord-336510-qzm9wgde	626	38	alpha	alpha	NN
cord-336510-qzm9wgde	626	39	/	/	SYM
cord-336510-qzm9wgde	626	40	beta	beta	JJ
cord-336510-qzm9wgde	626	41	interferon	interferon	NN
cord-336510-qzm9wgde	626	42	response	response	NN
cord-336510-qzm9wgde	626	43	of	of	IN
cord-336510-qzm9wgde	626	44	mouse	mouse	NN
cord-336510-qzm9wgde	626	45	peritoneal	peritoneal	JJ
cord-336510-qzm9wgde	626	46	macrophages	macrophage	NNS
cord-336510-qzm9wgde	626	47	to	to	IN
cord-336510-qzm9wgde	626	48	herpes	herpes	NN
cord-336510-qzm9wgde	626	49	simplex	simplex	NNP
cord-336510-qzm9wgde	626	50	virus	virus	NN
cord-336510-qzm9wgde	626	51	type	type	NN
cord-336510-qzm9wgde	627	1	The	the	DT
cord-336510-qzm9wgde	627	2	effect	effect	NN
cord-336510-qzm9wgde	627	3	of	of	IN
cord-336510-qzm9wgde	627	4	tuberculin	tuberculin	NN
cord-336510-qzm9wgde	627	5	on	on	IN
cord-336510-qzm9wgde	627	6	sensitized	sensitized	JJ
cord-336510-qzm9wgde	627	7	and	and	CC
cord-336510-qzm9wgde	627	8	normal	normal	JJ
cord-336510-qzm9wgde	627	9	leucocytes	leucocyte	NNS
cord-336510-qzm9wgde	627	10	Virus	Virus	NNP
cord-336510-qzm9wgde	627	11	interference	interference	NN
cord-336510-qzm9wgde	627	12	.	.	.
cord-336510-qzm9wgde	628	1	I.	I.	NNP
cord-336510-qzm9wgde	629	1	The	the	DT
cord-336510-qzm9wgde	629	2	interferon	interferon	NN
cord-336510-qzm9wgde	629	3	Interferons	Interferons	NNPS
cord-336510-qzm9wgde	629	4	,	,	,
cord-336510-qzm9wgde	629	5	interferon	interferon	NN
cord-336510-qzm9wgde	629	6	-	-	HYPH
cord-336510-qzm9wgde	629	7	like	like	JJ
cord-336510-qzm9wgde	629	8	cytokines	cytokine	NNS
cord-336510-qzm9wgde	629	9	,	,	,
cord-336510-qzm9wgde	629	10	and	and	CC
cord-336510-qzm9wgde	629	11	their	-PRON-	PRP$
cord-336510-qzm9wgde	629	12	receptors	receptor	NNS
cord-336510-qzm9wgde	629	13	Lymphokines	lymphokine	NNS
cord-336510-qzm9wgde	629	14	"	"	''
cord-336510-qzm9wgde	629	15	:	:	:
cord-336510-qzm9wgde	629	16	non	non	JJ
cord-336510-qzm9wgde	629	17	-	-	JJ
cord-336510-qzm9wgde	629	18	antibody	antibody	JJ
cord-336510-qzm9wgde	629	19	mediators	mediator	NNS
cord-336510-qzm9wgde	629	20	of	of	IN
cord-336510-qzm9wgde	629	21	cellular	cellular	JJ
cord-336510-qzm9wgde	629	22	immunity	immunity	NN
cord-336510-qzm9wgde	629	23	generated	generate	VBN
cord-336510-qzm9wgde	629	24	by	by	IN
cord-336510-qzm9wgde	629	25	lymphocyte	lymphocyte	NN
cord-336510-qzm9wgde	629	26	activation	activation	NN
cord-336510-qzm9wgde	629	27	Revised	revise	VBD
cord-336510-qzm9wgde	629	28	nomenclature	nomenclature	NN
cord-336510-qzm9wgde	629	29	for	for	IN
cord-336510-qzm9wgde	629	30	antigen	antigen	NN
cord-336510-qzm9wgde	629	31	-	-	HYPH
cord-336510-qzm9wgde	629	32	nonspecific	nonspecific	JJ
cord-336510-qzm9wgde	629	33	T	t	NN
cord-336510-qzm9wgde	629	34	-	-	HYPH
cord-336510-qzm9wgde	629	35	cell	cell	NN
cord-336510-qzm9wgde	629	36	proliferation	proliferation	NN
cord-336510-qzm9wgde	629	37	and	and	CC
cord-336510-qzm9wgde	629	38	helper	helper	NN
cord-336510-qzm9wgde	629	39	factors	factor	NNS
cord-336510-qzm9wgde	629	40	International	International	NNP
cord-336510-qzm9wgde	629	41	Lymphokine	Lymphokine	NNP
cord-336510-qzm9wgde	629	42	Nomenclature	Nomenclature	NNP
cord-336510-qzm9wgde	629	43	Committee	Committee	NNP
cord-336510-qzm9wgde	629	44	International	International	NNP
cord-336510-qzm9wgde	629	45	Union	Union	NNP
cord-336510-qzm9wgde	629	46	of	of	IN
cord-336510-qzm9wgde	629	47	Immunological	Immunological	NNP
cord-336510-qzm9wgde	629	48	Societies	Societies	NNPS
cord-336510-qzm9wgde	629	49	.	.	.
cord-336510-qzm9wgde	630	1	Nomenclature	Nomenclature	NNP
cord-336510-qzm9wgde	630	2	Committee	Committee	NNP
cord-336510-qzm9wgde	630	3	Working	Working	NNP
cord-336510-qzm9wgde	630	4	Group	Group	NNP
cord-336510-qzm9wgde	630	5	on	on	IN
cord-336510-qzm9wgde	630	6	Lymphokines	Lymphokines	NNPS
cord-336510-qzm9wgde	630	7	Interleukin	Interleukin	NNP
cord-336510-qzm9wgde	630	8	is	be	VBZ
cord-336510-qzm9wgde	630	9	as	as	IN
cord-336510-qzm9wgde	630	10	interleukin	interleukin	NN
cord-336510-qzm9wgde	630	11	does	do	VBZ
cord-336510-qzm9wgde	630	12	The	the	DT
cord-336510-qzm9wgde	630	13	cytokine	cytokine	NN
cord-336510-qzm9wgde	630	14	network	network	NN
cord-336510-qzm9wgde	630	15	Cytokines	Cytokines	NNPS
cord-336510-qzm9wgde	630	16	and	and	CC
cord-336510-qzm9wgde	630	17	cytokine	cytokine	NN
cord-336510-qzm9wgde	630	18	receptors	receptor	NNS
cord-336510-qzm9wgde	631	1	The	the	DT
cord-336510-qzm9wgde	631	2	role	role	NN
cord-336510-qzm9wgde	631	3	of	of	IN
cord-336510-qzm9wgde	631	4	interferon	interferon	NN
cord-336510-qzm9wgde	631	5	in	in	IN
cord-336510-qzm9wgde	631	6	the	the	DT
cord-336510-qzm9wgde	631	7	resistance	resistance	NN
cord-336510-qzm9wgde	631	8	of	of	IN
cord-336510-qzm9wgde	631	9	C57BL/6	C57BL/6	NNP
cord-336510-qzm9wgde	631	10	mice	mouse	NNS
cord-336510-qzm9wgde	631	11	to	to	IN
cord-336510-qzm9wgde	631	12	various	various	JJ
cord-336510-qzm9wgde	631	13	doses	dose	NNS
cord-336510-qzm9wgde	631	14	of	of	IN
cord-336510-qzm9wgde	631	15	herpes	herpes	NNP
cord-336510-qzm9wgde	631	16	simplex	simplex	NNP
cord-336510-qzm9wgde	631	17	virus	virus	NN
cord-336510-qzm9wgde	631	18	type	type	NN
cord-336510-qzm9wgde	631	19	1	1	CD
cord-336510-qzm9wgde	631	20	A	a	DT
cord-336510-qzm9wgde	631	21	protective	protective	JJ
cord-336510-qzm9wgde	631	22	action	action	NN
cord-336510-qzm9wgde	631	23	of	of	IN
cord-336510-qzm9wgde	631	24	neurotropic	neurotropic	NNP
cord-336510-qzm9wgde	631	25	against	against	IN
cord-336510-qzm9wgde	631	26	viscerotropic	viscerotropic	NNP
cord-336510-qzm9wgde	631	27	yellow	yellow	NNP
cord-336510-qzm9wgde	631	28	fever	fever	NNP
cord-336510-qzm9wgde	631	29	virus	virus	NN
cord-336510-qzm9wgde	631	30	in	in	IN
cord-336510-qzm9wgde	631	31	Macacus	Macacus	NNP
cord-336510-qzm9wgde	631	32	rhesus	rhesu	NNS
cord-336510-qzm9wgde	631	33	Interference	Interference	NNP
cord-336510-qzm9wgde	631	34	of	of	IN
cord-336510-qzm9wgde	631	35	inactive	inactive	JJ
cord-336510-qzm9wgde	631	36	virus	virus	NN
cord-336510-qzm9wgde	631	37	with	with	IN
cord-336510-qzm9wgde	631	38	the	the	DT
cord-336510-qzm9wgde	631	39	propagation	propagation	NN
cord-336510-qzm9wgde	631	40	of	of	IN
cord-336510-qzm9wgde	631	41	virus	virus	NN
cord-336510-qzm9wgde	631	42	of	of	IN
cord-336510-qzm9wgde	631	43	influenza	influenza	NN
cord-336510-qzm9wgde	631	44	Henle	Henle	NNP
cord-336510-qzm9wgde	631	45	W	W	NNP
cord-336510-qzm9wgde	631	46	:	:	:
cord-336510-qzm9wgde	632	1	Interference	interference	NN
cord-336510-qzm9wgde	632	2	phenomena	phenomenon	NNS
cord-336510-qzm9wgde	632	3	between	between	IN
cord-336510-qzm9wgde	632	4	animal	animal	NN
cord-336510-qzm9wgde	632	5	viruses	virus	NNS
cord-336510-qzm9wgde	632	6	;	;	:
cord-336510-qzm9wgde	632	7	a	a	DT
cord-336510-qzm9wgde	632	8	review	review	NN
cord-336510-qzm9wgde	632	9	Interferons	interferon	NNS
cord-336510-qzm9wgde	632	10	and	and	CC
cord-336510-qzm9wgde	632	11	their	-PRON-	PRP$
cord-336510-qzm9wgde	632	12	actions	action	NNS
cord-336510-qzm9wgde	633	1	Interferon	interferon	NN
cord-336510-qzm9wgde	633	2	-	-	HYPH
cord-336510-qzm9wgde	633	3	zeta	zeta	NNP
cord-336510-qzm9wgde	633	4	/	/	SYM
cord-336510-qzm9wgde	633	5	limitin	limitin	NNP
cord-336510-qzm9wgde	633	6	:	:	:
cord-336510-qzm9wgde	633	7	novel	novel	NN
cord-336510-qzm9wgde	633	8	type	type	NN
cord-336510-qzm9wgde	634	1	I	-PRON-	PRP
cord-336510-qzm9wgde	635	1	interferon	interferon	NN
cord-336510-qzm9wgde	635	2	that	that	WDT
cord-336510-qzm9wgde	635	3	displays	display	VBZ
cord-336510-qzm9wgde	635	4	a	a	DT
cord-336510-qzm9wgde	635	5	narrow	narrow	JJ
cord-336510-qzm9wgde	635	6	range	range	NN
cord-336510-qzm9wgde	635	7	of	of	IN
cord-336510-qzm9wgde	635	8	biological	biological	JJ
cord-336510-qzm9wgde	635	9	activity	activity	NN
cord-336510-qzm9wgde	635	10	Characterization	characterization	NN
cord-336510-qzm9wgde	635	11	of	of	IN
cord-336510-qzm9wgde	635	12	the	the	DT
cord-336510-qzm9wgde	635	13	murine	murine	JJ
cord-336510-qzm9wgde	635	14	alpha	alpha	NN
cord-336510-qzm9wgde	635	15	interferon	interferon	NN
cord-336510-qzm9wgde	635	16	gene	gene	NN
cord-336510-qzm9wgde	635	17	family	family	NN
cord-336510-qzm9wgde	635	18	Antiproliferative	Antiproliferative	NNP
cord-336510-qzm9wgde	635	19	and	and	CC
cord-336510-qzm9wgde	635	20	antiviral	antiviral	JJ
cord-336510-qzm9wgde	635	21	activities	activity	NNS
cord-336510-qzm9wgde	635	22	of	of	IN
cord-336510-qzm9wgde	635	23	human	human	JJ
cord-336510-qzm9wgde	635	24	leukocyte	leukocyte	NN
cord-336510-qzm9wgde	635	25	interferons	interferon	NNS
cord-336510-qzm9wgde	636	1	A	a	DT
cord-336510-qzm9wgde	636	2	species	species	NN
cord-336510-qzm9wgde	636	3	of	of	IN
cord-336510-qzm9wgde	636	4	human	human	JJ
cord-336510-qzm9wgde	636	5	alpha	alpha	NN
cord-336510-qzm9wgde	636	6	interferon	interferon	NN
cord-336510-qzm9wgde	636	7	that	that	WDT
cord-336510-qzm9wgde	636	8	lacks	lack	VBZ
cord-336510-qzm9wgde	636	9	the	the	DT
cord-336510-qzm9wgde	636	10	ability	ability	NN
cord-336510-qzm9wgde	636	11	to	to	TO
cord-336510-qzm9wgde	636	12	boost	boost	VB
cord-336510-qzm9wgde	636	13	human	human	JJ
cord-336510-qzm9wgde	636	14	natural	natural	JJ
cord-336510-qzm9wgde	636	15	killer	killer	NN
cord-336510-qzm9wgde	636	16	activity	activity	NN
cord-336510-qzm9wgde	636	17	Structural	structural	JJ
cord-336510-qzm9wgde	636	18	and	and	CC
cord-336510-qzm9wgde	636	19	functional	functional	JJ
cord-336510-qzm9wgde	636	20	differences	difference	NNS
cord-336510-qzm9wgde	636	21	between	between	IN
cord-336510-qzm9wgde	636	22	glycosylated	glycosylated	JJ
cord-336510-qzm9wgde	636	23	and	and	CC
cord-336510-qzm9wgde	636	24	non	non	JJ
cord-336510-qzm9wgde	636	25	-	-	JJ
cord-336510-qzm9wgde	636	26	glycosylated	glycosylated	JJ
cord-336510-qzm9wgde	636	27	forms	form	NNS
cord-336510-qzm9wgde	636	28	of	of	IN
cord-336510-qzm9wgde	636	29	human	human	JJ
cord-336510-qzm9wgde	636	30	interferon	interferon	NN
cord-336510-qzm9wgde	636	31	-	-	HYPH
cord-336510-qzm9wgde	636	32	beta	beta	NN
cord-336510-qzm9wgde	636	33	(	(	-LRB-
cord-336510-qzm9wgde	636	34	IFN	IFN	NNP
cord-336510-qzm9wgde	636	35	-	-	HYPH
cord-336510-qzm9wgde	636	36	beta	beta	NN
cord-336510-qzm9wgde	636	37	)	)	-RRB-
cord-336510-qzm9wgde	636	38	Human	human	JJ
cord-336510-qzm9wgde	636	39	cytokines	cytokine	NNS
cord-336510-qzm9wgde	636	40	-Handbook	-Handbook	:
cord-336510-qzm9wgde	636	41	for	for	IN
cord-336510-qzm9wgde	636	42	basic	basic	JJ
cord-336510-qzm9wgde	636	43	and	and	CC
cord-336510-qzm9wgde	636	44	clinical	clinical	JJ
cord-336510-qzm9wgde	636	45	research	research	NN
cord-336510-qzm9wgde	636	46	1st	1st	NN
cord-336510-qzm9wgde	636	47	edition	edition	NN
cord-336510-qzm9wgde	636	48	Signal	Signal	NNP
cord-336510-qzm9wgde	636	49	transduction	transduction	NN
cord-336510-qzm9wgde	636	50	by	by	IN
cord-336510-qzm9wgde	636	51	type	type	NN
cord-336510-qzm9wgde	637	1	I	-PRON-	PRP
cord-336510-qzm9wgde	637	2	interferons	interferons	VBP
cord-336510-qzm9wgde	637	3	Limitin	Limitin	NNP
cord-336510-qzm9wgde	637	4	:	:	:
cord-336510-qzm9wgde	638	1	An	an	DT
cord-336510-qzm9wgde	638	2	interferon	interferon	NN
cord-336510-qzm9wgde	638	3	-	-	HYPH
cord-336510-qzm9wgde	638	4	like	like	JJ
cord-336510-qzm9wgde	638	5	cytokine	cytokine	NN
cord-336510-qzm9wgde	638	6	that	that	WDT
cord-336510-qzm9wgde	638	7	preferentially	preferentially	RB
cord-336510-qzm9wgde	638	8	influences	influence	VBZ
cord-336510-qzm9wgde	638	9	B	b	NN
cord-336510-qzm9wgde	638	10	-	-	HYPH
cord-336510-qzm9wgde	638	11	lymphocyte	lymphocyte	NN
cord-336510-qzm9wgde	638	12	precursors	precursor	NNS
cord-336510-qzm9wgde	638	13	Antiviral	antiviral	JJ
cord-336510-qzm9wgde	638	14	activity	activity	NN
cord-336510-qzm9wgde	638	15	of	of	IN
cord-336510-qzm9wgde	638	16	limitin	limitin	NNP
cord-336510-qzm9wgde	638	17	against	against	IN
cord-336510-qzm9wgde	638	18	encephalomyocarditis	encephalomyocarditis	NNP
cord-336510-qzm9wgde	638	19	virus	virus	NN
cord-336510-qzm9wgde	638	20	,	,	,
cord-336510-qzm9wgde	638	21	herpes	herpes	NN
cord-336510-qzm9wgde	638	22	simplex	simplex	NNP
cord-336510-qzm9wgde	638	23	virus	virus	NN
cord-336510-qzm9wgde	638	24	,	,	,
cord-336510-qzm9wgde	638	25	and	and	CC
cord-336510-qzm9wgde	638	26	mouse	mouse	NNP
cord-336510-qzm9wgde	638	27	hepatitis	hepatitis	NNP
cord-336510-qzm9wgde	638	28	virus	virus	NN
cord-336510-qzm9wgde	638	29	:	:	:
cord-336510-qzm9wgde	639	1	diverse	diverse	JJ
cord-336510-qzm9wgde	639	2	requirements	requirement	NNS
cord-336510-qzm9wgde	639	3	by	by	IN
cord-336510-qzm9wgde	639	4	limitin	limitin	NNP
cord-336510-qzm9wgde	639	5	and	and	CC
cord-336510-qzm9wgde	639	6	alpha	alpha	NN
cord-336510-qzm9wgde	639	7	interferon	interferon	NN
cord-336510-qzm9wgde	639	8	for	for	IN
cord-336510-qzm9wgde	639	9	interferon	interferon	NN
cord-336510-qzm9wgde	639	10	regulatory	regulatory	JJ
cord-336510-qzm9wgde	639	11	factor	factor	NN
cord-336510-qzm9wgde	639	12	1	1	CD
cord-336510-qzm9wgde	639	13	Immune	immune	VBP
cord-336510-qzm9wgde	639	14	specific	specific	JJ
cord-336510-qzm9wgde	639	15	induction	induction	NN
cord-336510-qzm9wgde	639	16	of	of	IN
cord-336510-qzm9wgde	639	17	interferon	interferon	NN
cord-336510-qzm9wgde	639	18	production	production	NN
cord-336510-qzm9wgde	639	19	in	in	IN
cord-336510-qzm9wgde	639	20	cultures	culture	NNS
cord-336510-qzm9wgde	639	21	of	of	IN
cord-336510-qzm9wgde	639	22	human	human	JJ
cord-336510-qzm9wgde	639	23	blood	blood	NN
cord-336510-qzm9wgde	639	24	lymphocytes	lymphocyte	NNS
cord-336510-qzm9wgde	639	25	Regulation	regulation	NN
cord-336510-qzm9wgde	639	26	of	of	IN
cord-336510-qzm9wgde	639	27	macrophage	macrophage	NN
cord-336510-qzm9wgde	639	28	Ia	Ia	NNP
cord-336510-qzm9wgde	639	29	expression	expression	NN
cord-336510-qzm9wgde	639	30	in	in	IN
cord-336510-qzm9wgde	639	31	mice	mouse	NNS
cord-336510-qzm9wgde	639	32	with	with	IN
cord-336510-qzm9wgde	639	33	severe	severe	JJ
cord-336510-qzm9wgde	639	34	combined	combine	VBN
cord-336510-qzm9wgde	639	35	immunodeficiency	immunodeficiency	NN
cord-336510-qzm9wgde	639	36	:	:	:
cord-336510-qzm9wgde	639	37	induction	induction	NN
cord-336510-qzm9wgde	639	38	of	of	IN
cord-336510-qzm9wgde	639	39	Ia	Ia	NNP
cord-336510-qzm9wgde	639	40	expression	expression	NN
cord-336510-qzm9wgde	639	41	by	by	IN
cord-336510-qzm9wgde	639	42	a	a	DT
cord-336510-qzm9wgde	639	43	T	T	NNP
cord-336510-qzm9wgde	639	44	cellindependent	cellindependent	NN
cord-336510-qzm9wgde	639	45	mechanism	mechanism	NN
cord-336510-qzm9wgde	639	46	A	a	DT
cord-336510-qzm9wgde	639	47	T	T	NNP
cord-336510-qzm9wgde	639	48	cell	cell	NN
cord-336510-qzm9wgde	639	49	-	-	HYPH
cord-336510-qzm9wgde	639	50	independent	independent	JJ
cord-336510-qzm9wgde	639	51	mechanism	mechanism	NN
cord-336510-qzm9wgde	639	52	of	of	IN
cord-336510-qzm9wgde	639	53	macrophage	macrophage	NN
cord-336510-qzm9wgde	639	54	activation	activation	NN
cord-336510-qzm9wgde	639	55	by	by	IN
cord-336510-qzm9wgde	639	56	interferon	interferon	NN
cord-336510-qzm9wgde	639	57	-	-	HYPH
cord-336510-qzm9wgde	639	58	gamma	gamma	NN
cord-336510-qzm9wgde	639	59	Regulation	regulation	NN
cord-336510-qzm9wgde	639	60	of	of	IN
cord-336510-qzm9wgde	639	61	interferon	interferon	NN
cord-336510-qzm9wgde	639	62	-	-	HYPH
cord-336510-qzm9wgde	639	63	gamma	gamma	NN
cord-336510-qzm9wgde	639	64	gene	gene	NN
cord-336510-qzm9wgde	639	65	expression	expression	NN
cord-336510-qzm9wgde	640	1	The	the	DT
cord-336510-qzm9wgde	640	2	production	production	NN
cord-336510-qzm9wgde	640	3	of	of	IN
cord-336510-qzm9wgde	640	4	IFN	IFN	NNP
cord-336510-qzm9wgde	640	5	-	-	HYPH
cord-336510-qzm9wgde	640	6	gamma	gamma	NN
cord-336510-qzm9wgde	640	7	by	by	IN
cord-336510-qzm9wgde	640	8	IL-12	IL-12	NNP
cord-336510-qzm9wgde	640	9	/	/	SYM
cord-336510-qzm9wgde	640	10	IL-18-activated	il-18-activate	VBN
cord-336510-qzm9wgde	640	11	macrophages	macrophage	NNS
cord-336510-qzm9wgde	640	12	requires	require	VBZ
cord-336510-qzm9wgde	640	13	STAT4	stat4	NN
cord-336510-qzm9wgde	640	14	signaling	signal	VBG
cord-336510-qzm9wgde	640	15	and	and	CC
cord-336510-qzm9wgde	640	16	is	be	VBZ
cord-336510-qzm9wgde	640	17	inhibited	inhibit	VBN
cord-336510-qzm9wgde	640	18	by	by	IN
cord-336510-qzm9wgde	640	19	IL-4	IL-4	NNP
cord-336510-qzm9wgde	640	20	Interleukin	Interleukin	NNP
cord-336510-qzm9wgde	640	21	18	18	CD
cord-336510-qzm9wgde	640	22	together	together	RB
cord-336510-qzm9wgde	640	23	with	with	IN
cord-336510-qzm9wgde	640	24	interleukin	interleukin	NN
cord-336510-qzm9wgde	640	25	12	12	CD
cord-336510-qzm9wgde	640	26	inhibits	inhibit	NNS
cord-336510-qzm9wgde	640	27	IgE	ige	NN
cord-336510-qzm9wgde	640	28	production	production	NN
cord-336510-qzm9wgde	640	29	by	by	IN
cord-336510-qzm9wgde	640	30	induction	induction	NN
cord-336510-qzm9wgde	640	31	of	of	IN
cord-336510-qzm9wgde	640	32	interferon	interferon	NN
cord-336510-qzm9wgde	640	33	-	-	HYPH
cord-336510-qzm9wgde	640	34	gamma	gamma	NN
cord-336510-qzm9wgde	640	35	production	production	NN
cord-336510-qzm9wgde	640	36	from	from	IN
cord-336510-qzm9wgde	640	37	activated	activate	VBN
cord-336510-qzm9wgde	640	38	B	b	NN
cord-336510-qzm9wgde	640	39	cells	cell	NNS
cord-336510-qzm9wgde	640	40	IL-12	il-12	VBP
cord-336510-qzm9wgde	640	41	up	up	RB
cord-336510-qzm9wgde	640	42	-	-	HYPH
cord-336510-qzm9wgde	640	43	regulates	regulate	VBZ
cord-336510-qzm9wgde	640	44	IL-18	IL-18	NNP
cord-336510-qzm9wgde	640	45	receptor	receptor	NN
cord-336510-qzm9wgde	640	46	expression	expression	NN
cord-336510-qzm9wgde	640	47	on	on	IN
cord-336510-qzm9wgde	640	48	T	t	NN
cord-336510-qzm9wgde	640	49	cells	cell	NNS
cord-336510-qzm9wgde	640	50	,	,	,
cord-336510-qzm9wgde	640	51	Th1	th1	NN
cord-336510-qzm9wgde	640	52	cells	cell	NNS
cord-336510-qzm9wgde	640	53	,	,	,
cord-336510-qzm9wgde	640	54	and	and	CC
cord-336510-qzm9wgde	640	55	B	b	NN
cord-336510-qzm9wgde	640	56	cells	cell	NNS
cord-336510-qzm9wgde	640	57	:	:	:
cord-336510-qzm9wgde	640	58	synergism	synergism	NN
cord-336510-qzm9wgde	640	59	with	with	IN
cord-336510-qzm9wgde	640	60	IL-18	IL-18	NNP
cord-336510-qzm9wgde	640	61	for	for	IN
cord-336510-qzm9wgde	640	62	IFN	IFN	NNP
cord-336510-qzm9wgde	640	63	-	-	HYPH
cord-336510-qzm9wgde	640	64	gamma	gamma	NN
cord-336510-qzm9wgde	640	65	production	production	NN
cord-336510-qzm9wgde	640	66	IFN	IFN	NNP
cord-336510-qzm9wgde	640	67	-	-	HYPH
cord-336510-qzm9wgde	640	68	gamma	gamma	JJ
cord-336510-qzm9wgde	640	69	expression	expression	NN
cord-336510-qzm9wgde	640	70	in	in	IN
cord-336510-qzm9wgde	640	71	macrophages	macrophage	NNS
cord-336510-qzm9wgde	640	72	and	and	CC
cord-336510-qzm9wgde	640	73	its	-PRON-	PRP$
cord-336510-qzm9wgde	640	74	possible	possible	JJ
cord-336510-qzm9wgde	640	75	biological	biological	JJ
cord-336510-qzm9wgde	640	76	significance	significance	NN
cord-336510-qzm9wgde	640	77	Cutting	cut	VBG
cord-336510-qzm9wgde	640	78	edge	edge	NN
cord-336510-qzm9wgde	640	79	:	:	:
cord-336510-qzm9wgde	640	80	Cross	cross	NN
cord-336510-qzm9wgde	640	81	-	-	NN
cord-336510-qzm9wgde	640	82	talk	talk	NN
cord-336510-qzm9wgde	640	83	between	between	IN
cord-336510-qzm9wgde	640	84	cells	cell	NNS
cord-336510-qzm9wgde	640	85	of	of	IN
cord-336510-qzm9wgde	640	86	the	the	DT
cord-336510-qzm9wgde	640	87	innate	innate	JJ
cord-336510-qzm9wgde	640	88	immune	immune	JJ
cord-336510-qzm9wgde	640	89	system	system	NN
cord-336510-qzm9wgde	640	90	:	:	:
cord-336510-qzm9wgde	640	91	NKT	NKT	NNP
cord-336510-qzm9wgde	640	92	cells	cell	NNS
cord-336510-qzm9wgde	640	93	rapidly	rapidly	RB
cord-336510-qzm9wgde	640	94	activate	activate	VBP
cord-336510-qzm9wgde	640	95	NK	NK	NNP
cord-336510-qzm9wgde	640	96	cells	cell	NNS
cord-336510-qzm9wgde	640	97	IFN	IFN	NNP
cord-336510-qzm9wgde	640	98	-	-	HYPH
cord-336510-qzm9wgde	640	99	gamma	gamma	NN
cord-336510-qzm9wgde	640	100	production	production	NN
cord-336510-qzm9wgde	640	101	by	by	IN
cord-336510-qzm9wgde	640	102	antigen	antigen	NN
cord-336510-qzm9wgde	640	103	-	-	HYPH
cord-336510-qzm9wgde	640	104	presenting	present	VBG
cord-336510-qzm9wgde	640	105	cells	cell	NNS
cord-336510-qzm9wgde	640	106	:	:	:
cord-336510-qzm9wgde	640	107	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	640	108	emerge	emerge	VBP
cord-336510-qzm9wgde	640	109	Congenital	congenital	JJ
cord-336510-qzm9wgde	640	110	defects	defect	NNS
cord-336510-qzm9wgde	640	111	in	in	IN
cord-336510-qzm9wgde	640	112	the	the	DT
cord-336510-qzm9wgde	640	113	interferon	interferon	NN
cord-336510-qzm9wgde	640	114	-	-	HYPH
cord-336510-qzm9wgde	640	115	gamma	gamma	NN
cord-336510-qzm9wgde	640	116	/	/	SYM
cord-336510-qzm9wgde	640	117	interleukin-12	interleukin-12	NN
cord-336510-qzm9wgde	640	118	pathway	pathway	NN
cord-336510-qzm9wgde	641	1	Interferon	interferon	NN
cord-336510-qzm9wgde	641	2	-	-	HYPH
cord-336510-qzm9wgde	641	3	gamma	gamma	NN
cord-336510-qzm9wgde	641	4	:	:	:
cord-336510-qzm9wgde	641	5	an	an	DT
cord-336510-qzm9wgde	641	6	overview	overview	NN
cord-336510-qzm9wgde	641	7	of	of	IN
cord-336510-qzm9wgde	641	8	signals	signal	NNS
cord-336510-qzm9wgde	641	9	,	,	,
cord-336510-qzm9wgde	641	10	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	641	11	and	and	CC
cord-336510-qzm9wgde	641	12	functions	function	NNS
cord-336510-qzm9wgde	641	13	Tumor	tumor	NN
cord-336510-qzm9wgde	641	14	necrosis	necrosis	NN
cord-336510-qzm9wgde	641	15	factor	factor	NN
cord-336510-qzm9wgde	641	16	is	be	VBZ
cord-336510-qzm9wgde	641	17	involved	involve	VBN
cord-336510-qzm9wgde	641	18	in	in	IN
cord-336510-qzm9wgde	641	19	the	the	DT
cord-336510-qzm9wgde	641	20	T	T	NNP
cord-336510-qzm9wgde	641	21	cell	cell	NN
cord-336510-qzm9wgde	641	22	-	-	HYPH
cord-336510-qzm9wgde	641	23	independent	independent	JJ
cord-336510-qzm9wgde	641	24	pathway	pathway	NN
cord-336510-qzm9wgde	641	25	of	of	IN
cord-336510-qzm9wgde	641	26	macrophage	macrophage	NN
cord-336510-qzm9wgde	641	27	activation	activation	NN
cord-336510-qzm9wgde	641	28	in	in	IN
cord-336510-qzm9wgde	641	29	scid	scid	NNP
cord-336510-qzm9wgde	641	30	mice	mice	NNP
cord-336510-qzm9wgde	641	31	Regulatory	regulatory	JJ
cord-336510-qzm9wgde	641	32	pathways	pathway	NNS
cord-336510-qzm9wgde	641	33	involved	involve	VBN
cord-336510-qzm9wgde	641	34	in	in	IN
cord-336510-qzm9wgde	641	35	the	the	DT
cord-336510-qzm9wgde	641	36	infection	infection	NN
cord-336510-qzm9wgde	641	37	-	-	HYPH
cord-336510-qzm9wgde	641	38	induced	induce	VBN
cord-336510-qzm9wgde	641	39	production	production	NN
cord-336510-qzm9wgde	641	40	of	of	IN
cord-336510-qzm9wgde	641	41	IFN	IFN	NNP
cord-336510-qzm9wgde	641	42	-	-	HYPH
cord-336510-qzm9wgde	641	43	gamma	gamma	NN
cord-336510-qzm9wgde	641	44	by	by	IN
cord-336510-qzm9wgde	641	45	NK	NK	NNP
cord-336510-qzm9wgde	641	46	cells	cell	NNS
cord-336510-qzm9wgde	641	47	Seeing	see	VBG
cord-336510-qzm9wgde	641	48	the	the	DT
cord-336510-qzm9wgde	641	49	light	light	NN
cord-336510-qzm9wgde	641	50	:	:	:
cord-336510-qzm9wgde	641	51	preassembly	preassembly	NN
cord-336510-qzm9wgde	641	52	and	and	CC
cord-336510-qzm9wgde	641	53	ligand	ligand	NN
cord-336510-qzm9wgde	641	54	-	-	HYPH
cord-336510-qzm9wgde	641	55	induced	induce	VBN
cord-336510-qzm9wgde	641	56	changes	change	NNS
cord-336510-qzm9wgde	641	57	of	of	IN
cord-336510-qzm9wgde	641	58	the	the	DT
cord-336510-qzm9wgde	641	59	interferon	interferon	NNP
cord-336510-qzm9wgde	641	60	gamma	gamma	NNP
cord-336510-qzm9wgde	641	61	receptor	receptor	NN
cord-336510-qzm9wgde	641	62	complex	complex	NN
cord-336510-qzm9wgde	641	63	in	in	IN
cord-336510-qzm9wgde	641	64	cells	cell	NNS
cord-336510-qzm9wgde	641	65	STATs	stat	NNS
cord-336510-qzm9wgde	641	66	dimerize	dimerize	JJ
cord-336510-qzm9wgde	641	67	in	in	IN
cord-336510-qzm9wgde	641	68	the	the	DT
cord-336510-qzm9wgde	641	69	absence	absence	NN
cord-336510-qzm9wgde	641	70	of	of	IN
cord-336510-qzm9wgde	641	71	phosphorylation	phosphorylation	NN
cord-336510-qzm9wgde	641	72	N	n	NN
cord-336510-qzm9wgde	641	73	-	-	HYPH
cord-336510-qzm9wgde	641	74	domaindependent	domaindependent	NNP
cord-336510-qzm9wgde	642	1	nonphosphorylated	nonphosphorylate	VBN
cord-336510-qzm9wgde	643	1	STAT4	stat4	NN
cord-336510-qzm9wgde	643	2	dimers	dimer	NNS
cord-336510-qzm9wgde	643	3	required	require	VBN
cord-336510-qzm9wgde	643	4	for	for	IN
cord-336510-qzm9wgde	643	5	cytokine	cytokine	NN
cord-336510-qzm9wgde	643	6	-	-	HYPH
cord-336510-qzm9wgde	643	7	driven	drive	VBN
cord-336510-qzm9wgde	643	8	activation	activation	NN
cord-336510-qzm9wgde	643	9	So	so	IN
cord-336510-qzm9wgde	643	10	many	many	JJ
cord-336510-qzm9wgde	643	11	ligands	ligand	NNS
cord-336510-qzm9wgde	643	12	,	,	,
cord-336510-qzm9wgde	643	13	so	so	RB
cord-336510-qzm9wgde	643	14	few	few	JJ
cord-336510-qzm9wgde	643	15	transcription	transcription	NN
cord-336510-qzm9wgde	643	16	factors	factor	NNS
cord-336510-qzm9wgde	643	17	:	:	:
cord-336510-qzm9wgde	643	18	a	a	DT
cord-336510-qzm9wgde	643	19	new	new	JJ
cord-336510-qzm9wgde	643	20	paradigm	paradigm	NN
cord-336510-qzm9wgde	643	21	for	for	IN
cord-336510-qzm9wgde	643	22	signaling	signal	VBG
cord-336510-qzm9wgde	643	23	through	through	IN
cord-336510-qzm9wgde	643	24	the	the	DT
cord-336510-qzm9wgde	643	25	STAT	stat	NN
cord-336510-qzm9wgde	643	26	transcription	transcription	NN
cord-336510-qzm9wgde	643	27	factors	factor	NNS
cord-336510-qzm9wgde	643	28	GAS	gas	NN
cord-336510-qzm9wgde	643	29	elements	element	NNS
cord-336510-qzm9wgde	643	30	:	:	:
cord-336510-qzm9wgde	643	31	a	a	DT
cord-336510-qzm9wgde	643	32	few	few	JJ
cord-336510-qzm9wgde	643	33	nucleotides	nucleotide	NNS
cord-336510-qzm9wgde	643	34	with	with	IN
cord-336510-qzm9wgde	643	35	a	a	DT
cord-336510-qzm9wgde	643	36	major	major	JJ
cord-336510-qzm9wgde	643	37	impact	impact	NN
cord-336510-qzm9wgde	643	38	on	on	IN
cord-336510-qzm9wgde	643	39	cytokine	cytokine	NN
cord-336510-qzm9wgde	643	40	-	-	HYPH
cord-336510-qzm9wgde	643	41	induced	induce	VBN
cord-336510-qzm9wgde	643	42	gene	gene	NN
cord-336510-qzm9wgde	643	43	expression	expression	NN
cord-336510-qzm9wgde	643	44	Interleukin-4	Interleukin-4	NNP
cord-336510-qzm9wgde	643	45	and	and	CC
cord-336510-qzm9wgde	643	46	interferon	interferon	NN
cord-336510-qzm9wgde	643	47	-	-	HYPH
cord-336510-qzm9wgde	643	48	gamma	gamma	NN
cord-336510-qzm9wgde	643	49	:	:	:
cord-336510-qzm9wgde	643	50	the	the	DT
cord-336510-qzm9wgde	643	51	quintessence	quintessence	NN
cord-336510-qzm9wgde	643	52	of	of	IN
cord-336510-qzm9wgde	643	53	a	a	DT
cord-336510-qzm9wgde	643	54	mutual	mutual	JJ
cord-336510-qzm9wgde	643	55	antagonistic	antagonistic	JJ
cord-336510-qzm9wgde	643	56	relationship	relationship	NN
cord-336510-qzm9wgde	643	57	Alterations	alteration	NNS
cord-336510-qzm9wgde	643	58	of	of	IN
cord-336510-qzm9wgde	643	59	macrophage	macrophage	NN
cord-336510-qzm9wgde	643	60	functions	function	NNS
cord-336510-qzm9wgde	643	61	by	by	IN
cord-336510-qzm9wgde	643	62	mediators	mediator	NNS
cord-336510-qzm9wgde	643	63	from	from	IN
cord-336510-qzm9wgde	643	64	lymphocytes	lymphocyte	NNS
cord-336510-qzm9wgde	643	65	Identification	identification	NN
cord-336510-qzm9wgde	643	66	of	of	IN
cord-336510-qzm9wgde	643	67	interferon	interferon	NN
cord-336510-qzm9wgde	643	68	-	-	HYPH
cord-336510-qzm9wgde	643	69	gamma	gamma	NN
cord-336510-qzm9wgde	643	70	as	as	IN
cord-336510-qzm9wgde	643	71	the	the	DT
cord-336510-qzm9wgde	643	72	lymphokine	lymphokine	NN
cord-336510-qzm9wgde	643	73	that	that	WDT
cord-336510-qzm9wgde	643	74	activates	activate	VBZ
cord-336510-qzm9wgde	643	75	human	human	JJ
cord-336510-qzm9wgde	643	76	macrophage	macrophage	NN
cord-336510-qzm9wgde	643	77	oxidative	oxidative	JJ
cord-336510-qzm9wgde	643	78	metabolism	metabolism	NN
cord-336510-qzm9wgde	643	79	and	and	CC
cord-336510-qzm9wgde	643	80	antimicrobial	antimicrobial	JJ
cord-336510-qzm9wgde	643	81	activity	activity	NN
cord-336510-qzm9wgde	643	82	Monoclonal	Monoclonal	NNP
cord-336510-qzm9wgde	643	83	antibodies	antibody	NNS
cord-336510-qzm9wgde	643	84	to	to	IN
cord-336510-qzm9wgde	643	85	murine	murine	JJ
cord-336510-qzm9wgde	643	86	gamma	gamma	NN
cord-336510-qzm9wgde	643	87	-	-	HYPH
cord-336510-qzm9wgde	643	88	interferon	interferon	NN
cord-336510-qzm9wgde	643	89	which	which	WDT
cord-336510-qzm9wgde	643	90	differentially	differentially	RB
cord-336510-qzm9wgde	643	91	modulate	modulate	VBP
cord-336510-qzm9wgde	643	92	macrophage	macrophage	NN
cord-336510-qzm9wgde	643	93	activation	activation	NN
cord-336510-qzm9wgde	643	94	and	and	CC
cord-336510-qzm9wgde	643	95	antiviral	antiviral	JJ
cord-336510-qzm9wgde	643	96	activity	activity	NN
cord-336510-qzm9wgde	643	97	Characterization	characterization	NN
cord-336510-qzm9wgde	643	98	of	of	IN
cord-336510-qzm9wgde	643	99	herpes	herpes	NN
cord-336510-qzm9wgde	643	100	simplex	simplex	NN
cord-336510-qzm9wgde	643	101	virus	virus	NN
cord-336510-qzm9wgde	643	102	type-1	type-1	NN
cord-336510-qzm9wgde	643	103	infection	infection	NN
cord-336510-qzm9wgde	643	104	and	and	CC
cord-336510-qzm9wgde	643	105	herpetic	herpetic	JJ
cord-336510-qzm9wgde	643	106	stromal	stromal	JJ
cord-336510-qzm9wgde	643	107	keratitis	keratitis	NN
cord-336510-qzm9wgde	643	108	development	development	NN
cord-336510-qzm9wgde	643	109	in	in	IN
cord-336510-qzm9wgde	643	110	IFN	IFN	NNP
cord-336510-qzm9wgde	643	111	-	-	HYPH
cord-336510-qzm9wgde	643	112	gamma	gamma	JJ
cord-336510-qzm9wgde	643	113	knockout	knockout	NN
cord-336510-qzm9wgde	643	114	mice	mouse	NNS
cord-336510-qzm9wgde	644	1	Targeted	target	VBN
cord-336510-qzm9wgde	644	2	disruption	disruption	NN
cord-336510-qzm9wgde	644	3	of	of	IN
cord-336510-qzm9wgde	644	4	the	the	DT
cord-336510-qzm9wgde	644	5	mouse	mouse	NN
cord-336510-qzm9wgde	644	6	Stat1	stat1	POS
cord-336510-qzm9wgde	644	7	gene	gene	NN
cord-336510-qzm9wgde	644	8	results	result	NNS
cord-336510-qzm9wgde	644	9	in	in	IN
cord-336510-qzm9wgde	644	10	compromised	compromise	VBN
cord-336510-qzm9wgde	644	11	innate	innate	JJ
cord-336510-qzm9wgde	644	12	immunity	immunity	NN
cord-336510-qzm9wgde	644	13	to	to	IN
cord-336510-qzm9wgde	644	14	viral	viral	JJ
cord-336510-qzm9wgde	644	15	disease	disease	NN
cord-336510-qzm9wgde	644	16	Role	role	NN
cord-336510-qzm9wgde	644	17	of	of	IN
cord-336510-qzm9wgde	644	18	interferon	interferon	NN
cord-336510-qzm9wgde	644	19	-	-	HYPH
cord-336510-qzm9wgde	644	20	gamma	gamma	NN
cord-336510-qzm9wgde	644	21	in	in	IN
cord-336510-qzm9wgde	644	22	immunity	immunity	NN
cord-336510-qzm9wgde	644	23	to	to	IN
cord-336510-qzm9wgde	644	24	herpes	herpes	NNP
cord-336510-qzm9wgde	644	25	simplex	simplex	NNP
cord-336510-qzm9wgde	644	26	virus	virus	NN
cord-336510-qzm9wgde	645	1	The	the	DT
cord-336510-qzm9wgde	645	2	role	role	NN
cord-336510-qzm9wgde	645	3	of	of	IN
cord-336510-qzm9wgde	645	4	IL-12	IL-12	NNP
cord-336510-qzm9wgde	645	5	,	,	,
cord-336510-qzm9wgde	645	6	IL-23	IL-23	NNP
cord-336510-qzm9wgde	645	7	and	and	CC
cord-336510-qzm9wgde	645	8	IFN	IFN	NNP
cord-336510-qzm9wgde	645	9	-	-	HYPH
cord-336510-qzm9wgde	645	10	gamma	gamma	NN
cord-336510-qzm9wgde	645	11	in	in	IN
cord-336510-qzm9wgde	645	12	immunity	immunity	NN
cord-336510-qzm9wgde	645	13	to	to	IN
cord-336510-qzm9wgde	645	14	viruses	virus	NNS
cord-336510-qzm9wgde	645	15	IL-28	IL-28	NNP
cord-336510-qzm9wgde	645	16	,	,	,
cord-336510-qzm9wgde	645	17	IL-29	IL-29	NNP
cord-336510-qzm9wgde	645	18	and	and	CC
cord-336510-qzm9wgde	645	19	their	-PRON-	PRP$
cord-336510-qzm9wgde	645	20	class	class	NN
cord-336510-qzm9wgde	645	21	II	ii	CD
cord-336510-qzm9wgde	645	22	cytokine	cytokine	NN
cord-336510-qzm9wgde	645	23	receptor	receptor	NN
cord-336510-qzm9wgde	645	24	IL-28R	il-28r	NN
cord-336510-qzm9wgde	646	1	IFN	IFN	NNP
cord-336510-qzm9wgde	646	2	-	-	HYPH
cord-336510-qzm9wgde	646	3	lambdas	lambda	NNS
cord-336510-qzm9wgde	646	4	mediate	mediate	VBP
cord-336510-qzm9wgde	646	5	antiviral	antiviral	JJ
cord-336510-qzm9wgde	646	6	protection	protection	NN
cord-336510-qzm9wgde	646	7	through	through	IN
cord-336510-qzm9wgde	646	8	a	a	DT
cord-336510-qzm9wgde	646	9	distinct	distinct	JJ
cord-336510-qzm9wgde	646	10	class	class	NN
cord-336510-qzm9wgde	646	11	II	ii	NN
cord-336510-qzm9wgde	646	12	cytokine	cytokine	NN
cord-336510-qzm9wgde	646	13	receptor	receptor	NN
cord-336510-qzm9wgde	646	14	complex	complex	NN
cord-336510-qzm9wgde	646	15	Tumor	tumor	NN
cord-336510-qzm9wgde	646	16	necrosis	necrosis	NN
cord-336510-qzm9wgde	646	17	factors	factor	NNS
cord-336510-qzm9wgde	647	1	The	the	DT
cord-336510-qzm9wgde	647	2	TNF	TNF	NNP
cord-336510-qzm9wgde	647	3	superfamily	superfamily	NN
cord-336510-qzm9wgde	648	1	The	the	DT
cord-336510-qzm9wgde	648	2	new	new	JJ
cord-336510-qzm9wgde	648	3	TNF	TNF	NNP
cord-336510-qzm9wgde	648	4	nomenclature	nomenclature	NN
cord-336510-qzm9wgde	648	5	scheme	scheme	NN
cord-336510-qzm9wgde	648	6	2005	2005	CD
cord-336510-qzm9wgde	648	7	Localization	localization	NN
cord-336510-qzm9wgde	648	8	and	and	CC
cord-336510-qzm9wgde	648	9	post	post	JJ
cord-336510-qzm9wgde	648	10	-	-	JJ
cord-336510-qzm9wgde	648	11	Golgi	golgi	JJ
cord-336510-qzm9wgde	648	12	trafficking	trafficking	NN
cord-336510-qzm9wgde	648	13	of	of	IN
cord-336510-qzm9wgde	648	14	tumor	tumor	NN
cord-336510-qzm9wgde	648	15	necrosis	necrosis	NN
cord-336510-qzm9wgde	648	16	factoralpha	factoralpha	NN
cord-336510-qzm9wgde	648	17	in	in	IN
cord-336510-qzm9wgde	648	18	macrophages	macrophage	NNS
cord-336510-qzm9wgde	648	19	Metalloprotease	Metalloprotease	NNP
cord-336510-qzm9wgde	648	20	-	-	HYPH
cord-336510-qzm9wgde	648	21	disintegrins	disintegrin	NNS
cord-336510-qzm9wgde	648	22	:	:	:
cord-336510-qzm9wgde	648	23	links	link	NNS
cord-336510-qzm9wgde	648	24	to	to	IN
cord-336510-qzm9wgde	648	25	cell	cell	NN
cord-336510-qzm9wgde	648	26	adhesion	adhesion	NN
cord-336510-qzm9wgde	648	27	and	and	CC
cord-336510-qzm9wgde	648	28	cleavage	cleavage	NN
cord-336510-qzm9wgde	648	29	of	of	IN
cord-336510-qzm9wgde	648	30	TNF	TNF	NNP
cord-336510-qzm9wgde	648	31	alpha	alpha	NN
cord-336510-qzm9wgde	648	32	and	and	CC
cord-336510-qzm9wgde	648	33	Notch	Notch	NNP
cord-336510-qzm9wgde	648	34	Tumor	tumor	NN
cord-336510-qzm9wgde	648	35	necrosis	necrosis	NN
cord-336510-qzm9wgde	648	36	factor	factor	NN
cord-336510-qzm9wgde	648	37	(	(	-LRB-
cord-336510-qzm9wgde	648	38	TNF)-alpha	tnf)-alpha	CD
cord-336510-qzm9wgde	648	39	and	and	CC
cord-336510-qzm9wgde	648	40	TNF	TNF	NNP
cord-336510-qzm9wgde	648	41	receptors	receptor	NNS
cord-336510-qzm9wgde	648	42	in	in	IN
cord-336510-qzm9wgde	648	43	viral	viral	JJ
cord-336510-qzm9wgde	648	44	pathogenesis	pathogenesis	NN
cord-336510-qzm9wgde	648	45	Expression	expression	NN
cord-336510-qzm9wgde	648	46	of	of	IN
cord-336510-qzm9wgde	648	47	TNF	tnf	NN
cord-336510-qzm9wgde	648	48	-	-	HYPH
cord-336510-qzm9wgde	648	49	alpha	alpha	NN
cord-336510-qzm9wgde	648	50	by	by	IN
cord-336510-qzm9wgde	648	51	herpes	herpes	NNP
cord-336510-qzm9wgde	648	52	simplex	simplex	NNP
cord-336510-qzm9wgde	648	53	virus	virus	NN
cord-336510-qzm9wgde	648	54	-	-	HYPH
cord-336510-qzm9wgde	648	55	infected	infect	VBN
cord-336510-qzm9wgde	648	56	macrophages	macrophage	NNS
cord-336510-qzm9wgde	648	57	is	be	VBZ
cord-336510-qzm9wgde	648	58	regulated	regulate	VBN
cord-336510-qzm9wgde	648	59	by	by	IN
cord-336510-qzm9wgde	648	60	a	a	DT
cord-336510-qzm9wgde	648	61	dual	dual	JJ
cord-336510-qzm9wgde	648	62	mechanism	mechanism	NN
cord-336510-qzm9wgde	648	63	:	:	:
cord-336510-qzm9wgde	648	64	transcriptional	transcriptional	JJ
cord-336510-qzm9wgde	648	65	regulation	regulation	NN
cord-336510-qzm9wgde	648	66	by	by	IN
cord-336510-qzm9wgde	648	67	NF	nf	NN
cord-336510-qzm9wgde	648	68	-	-	HYPH
cord-336510-qzm9wgde	648	69	kappa	kappa	NN
cord-336510-qzm9wgde	648	70	B	b	NN
cord-336510-qzm9wgde	648	71	and	and	CC
cord-336510-qzm9wgde	648	72	activating	activate	VBG
cord-336510-qzm9wgde	648	73	transcription	transcription	NN
cord-336510-qzm9wgde	648	74	factor	factor	NN
cord-336510-qzm9wgde	648	75	2	2	CD
cord-336510-qzm9wgde	648	76	/	/	SYM
cord-336510-qzm9wgde	648	77	Jun	Jun	NNP
cord-336510-qzm9wgde	648	78	and	and	CC
cord-336510-qzm9wgde	648	79	translational	translational	JJ
cord-336510-qzm9wgde	648	80	regulation	regulation	NN
cord-336510-qzm9wgde	648	81	through	through	IN
cord-336510-qzm9wgde	648	82	the	the	DT
cord-336510-qzm9wgde	648	83	AU	AU	NNP
cord-336510-qzm9wgde	648	84	-	-	HYPH
cord-336510-qzm9wgde	648	85	rich	rich	JJ
cord-336510-qzm9wgde	648	86	region	region	NN
cord-336510-qzm9wgde	648	87	of	of	IN
cord-336510-qzm9wgde	648	88	the	the	DT
cord-336510-qzm9wgde	648	89	3	3	CD
cord-336510-qzm9wgde	648	90	'	'	POS
cord-336510-qzm9wgde	648	91	untranslated	untranslated	JJ
cord-336510-qzm9wgde	648	92	region	region	NN
cord-336510-qzm9wgde	648	93	Viruses	virus	NNS
cord-336510-qzm9wgde	648	94	and	and	CC
cord-336510-qzm9wgde	648	95	the	the	DT
cord-336510-qzm9wgde	648	96	TNF	TNF	NNP
cord-336510-qzm9wgde	648	97	-	-	HYPH
cord-336510-qzm9wgde	648	98	related	relate	VBN
cord-336510-qzm9wgde	648	99	cytokines	cytokine	NNS
cord-336510-qzm9wgde	648	100	,	,	,
cord-336510-qzm9wgde	648	101	an	an	DT
cord-336510-qzm9wgde	648	102	evolving	evolve	VBG
cord-336510-qzm9wgde	648	103	battle	battle	NN
cord-336510-qzm9wgde	648	104	NF	nf	NN
cord-336510-qzm9wgde	648	105	-	-	HYPH
cord-336510-qzm9wgde	648	106	kappaB	kappaB	NNP
cord-336510-qzm9wgde	648	107	and	and	CC
cord-336510-qzm9wgde	648	108	the	the	DT
cord-336510-qzm9wgde	648	109	innate	innate	JJ
cord-336510-qzm9wgde	648	110	immune	immune	JJ
cord-336510-qzm9wgde	648	111	response	response	NN
cord-336510-qzm9wgde	649	1	Soluble	soluble	JJ
cord-336510-qzm9wgde	649	2	tumor	tumor	NN
cord-336510-qzm9wgde	649	3	necrosis	necrosis	NN
cord-336510-qzm9wgde	649	4	factor	factor	NN
cord-336510-qzm9wgde	649	5	(	(	-LRB-
cord-336510-qzm9wgde	649	6	TNF	TNF	NNP
cord-336510-qzm9wgde	649	7	)	)	-RRB-
cord-336510-qzm9wgde	649	8	receptors	receptor	NNS
cord-336510-qzm9wgde	649	9	conserve	conserve	VBP
cord-336510-qzm9wgde	649	10	TNF	TNF	NNP
cord-336510-qzm9wgde	649	11	bioactivity	bioactivity	NN
cord-336510-qzm9wgde	649	12	in	in	IN
cord-336510-qzm9wgde	649	13	meningitis	meningitis	NN
cord-336510-qzm9wgde	649	14	patient	patient	JJ
cord-336510-qzm9wgde	649	15	spinal	spinal	JJ
cord-336510-qzm9wgde	649	16	fluid	fluid	JJ
cord-336510-qzm9wgde	649	17	Biological	Biological	NNP
cord-336510-qzm9wgde	649	18	functions	function	NNS
cord-336510-qzm9wgde	649	19	of	of	IN
cord-336510-qzm9wgde	649	20	tumor	tumor	NN
cord-336510-qzm9wgde	649	21	necrosis	necrosis	NN
cord-336510-qzm9wgde	649	22	factor	factor	NN
cord-336510-qzm9wgde	649	23	cytokines	cytokine	NNS
cord-336510-qzm9wgde	649	24	and	and	CC
cord-336510-qzm9wgde	649	25	their	-PRON-	PRP$
cord-336510-qzm9wgde	649	26	receptors	receptor	NNS
cord-336510-qzm9wgde	649	27	Identification	identification	NN
cord-336510-qzm9wgde	649	28	and	and	CC
cord-336510-qzm9wgde	649	29	purification	purification	NN
cord-336510-qzm9wgde	649	30	of	of	IN
cord-336510-qzm9wgde	649	31	natural	natural	JJ
cord-336510-qzm9wgde	649	32	killer	killer	NN
cord-336510-qzm9wgde	649	33	cell	cell	NN
cord-336510-qzm9wgde	649	34	stimulatory	stimulatory	JJ
cord-336510-qzm9wgde	649	35	factor	factor	NN
cord-336510-qzm9wgde	649	36	(	(	-LRB-
cord-336510-qzm9wgde	649	37	NKSF	NKSF	NNP
cord-336510-qzm9wgde	649	38	)	)	-RRB-
cord-336510-qzm9wgde	649	39	,	,	,
cord-336510-qzm9wgde	649	40	a	a	DT
cord-336510-qzm9wgde	649	41	cytokine	cytokine	NN
cord-336510-qzm9wgde	649	42	with	with	IN
cord-336510-qzm9wgde	649	43	multiple	multiple	JJ
cord-336510-qzm9wgde	649	44	biologic	biologic	JJ
cord-336510-qzm9wgde	649	45	effects	effect	NNS
cord-336510-qzm9wgde	649	46	on	on	IN
cord-336510-qzm9wgde	649	47	human	human	JJ
cord-336510-qzm9wgde	649	48	lymphocytes	lymphocyte	NNS
cord-336510-qzm9wgde	650	1	The	the	DT
cord-336510-qzm9wgde	650	2	IL-12	IL-12	NNP
cord-336510-qzm9wgde	650	3	family	family	NN
cord-336510-qzm9wgde	650	4	of	of	IN
cord-336510-qzm9wgde	650	5	heterodimeric	heterodimeric	NNP
cord-336510-qzm9wgde	650	6	cytokines	cytokine	NNS
cord-336510-qzm9wgde	650	7	:	:	:
cord-336510-qzm9wgde	650	8	new	new	JJ
cord-336510-qzm9wgde	650	9	players	player	NNS
cord-336510-qzm9wgde	650	10	in	in	IN
cord-336510-qzm9wgde	650	11	the	the	DT
cord-336510-qzm9wgde	650	12	regulation	regulation	NN
cord-336510-qzm9wgde	650	13	of	of	IN
cord-336510-qzm9wgde	650	14	T	T	NNP
cord-336510-qzm9wgde	650	15	cell	cell	NN
cord-336510-qzm9wgde	650	16	responses	response	NNS
cord-336510-qzm9wgde	651	1	The	the	DT
cord-336510-qzm9wgde	651	2	biology	biology	NN
cord-336510-qzm9wgde	651	3	of	of	IN
cord-336510-qzm9wgde	651	4	IL-12	IL-12	NNP
cord-336510-qzm9wgde	651	5	:	:	:
cord-336510-qzm9wgde	651	6	coordinating	coordinate	VBG
cord-336510-qzm9wgde	651	7	innate	innate	JJ
cord-336510-qzm9wgde	651	8	and	and	CC
cord-336510-qzm9wgde	651	9	adaptive	adaptive	JJ
cord-336510-qzm9wgde	651	10	immune	immune	JJ
cord-336510-qzm9wgde	651	11	responses	response	NNS
cord-336510-qzm9wgde	651	12	Coexpression	Coexpression	NNP
cord-336510-qzm9wgde	651	13	of	of	IN
cord-336510-qzm9wgde	651	14	two	two	CD
cord-336510-qzm9wgde	651	15	distinct	distinct	JJ
cord-336510-qzm9wgde	651	16	genes	gene	NNS
cord-336510-qzm9wgde	651	17	is	be	VBZ
cord-336510-qzm9wgde	651	18	required	require	VBN
cord-336510-qzm9wgde	651	19	to	to	TO
cord-336510-qzm9wgde	651	20	generate	generate	VB
cord-336510-qzm9wgde	651	21	secreted	secrete	VBN
cord-336510-qzm9wgde	651	22	bioactive	bioactive	JJ
cord-336510-qzm9wgde	651	23	cytotoxic	cytotoxic	JJ
cord-336510-qzm9wgde	651	24	lymphocyte	lymphocyte	NN
cord-336510-qzm9wgde	651	25	maturation	maturation	NN
cord-336510-qzm9wgde	651	26	factor	factor	NN
cord-336510-qzm9wgde	651	27	Production	production	NN
cord-336510-qzm9wgde	651	28	of	of	IN
cord-336510-qzm9wgde	651	29	natural	natural	JJ
cord-336510-qzm9wgde	651	30	killer	killer	NN
cord-336510-qzm9wgde	651	31	cell	cell	NN
cord-336510-qzm9wgde	651	32	stimulatory	stimulatory	JJ
cord-336510-qzm9wgde	651	33	factor	factor	NN
cord-336510-qzm9wgde	651	34	(	(	-LRB-
cord-336510-qzm9wgde	651	35	interleukin	interleukin	NN
cord-336510-qzm9wgde	651	36	12	12	CD
cord-336510-qzm9wgde	651	37	)	)	-RRB-
cord-336510-qzm9wgde	651	38	by	by	IN
cord-336510-qzm9wgde	651	39	peripheral	peripheral	JJ
cord-336510-qzm9wgde	651	40	blood	blood	NN
cord-336510-qzm9wgde	651	41	mononuclear	mononuclear	NN
cord-336510-qzm9wgde	651	42	cells	cell	NNS
cord-336510-qzm9wgde	652	1	Ellermann	Ellermann	NNP
cord-336510-qzm9wgde	652	2	-	-	HYPH
cord-336510-qzm9wgde	652	3	Eriksen	Eriksen	NNP
cord-336510-qzm9wgde	652	4	S	S	NNP
cord-336510-qzm9wgde	652	5	:	:	:
cord-336510-qzm9wgde	653	1	Herpes	Herpes	NNP
cord-336510-qzm9wgde	653	2	simplex	simplex	NN
cord-336510-qzm9wgde	653	3	virus	virus	NN
cord-336510-qzm9wgde	653	4	type	type	NN
cord-336510-qzm9wgde	653	5	2	2	CD
cord-336510-qzm9wgde	653	6	induces	induce	VBZ
cord-336510-qzm9wgde	653	7	secretion	secretion	NN
cord-336510-qzm9wgde	653	8	of	of	IN
cord-336510-qzm9wgde	653	9	IL-12	IL-12	NNP
cord-336510-qzm9wgde	653	10	by	by	IN
cord-336510-qzm9wgde	653	11	macrophages	macrophage	NNS
cord-336510-qzm9wgde	653	12	through	through	IN
cord-336510-qzm9wgde	653	13	a	a	DT
cord-336510-qzm9wgde	653	14	mechanism	mechanism	NN
cord-336510-qzm9wgde	653	15	involving	involve	VBG
cord-336510-qzm9wgde	653	16	NF	NF	NNP
cord-336510-qzm9wgde	653	17	-	-	HYPH
cord-336510-qzm9wgde	653	18	kappaB	kappaB	NNP
cord-336510-qzm9wgde	654	1	In	in	IN
cord-336510-qzm9wgde	654	2	vivo	vivo	NN
cord-336510-qzm9wgde	654	3	microbial	microbial	JJ
cord-336510-qzm9wgde	654	4	stimulation	stimulation	NN
cord-336510-qzm9wgde	654	5	induces	induce	VBZ
cord-336510-qzm9wgde	654	6	rapid	rapid	JJ
cord-336510-qzm9wgde	654	7	CD40	CD40	NNP
cord-336510-qzm9wgde	654	8	ligand	ligand	NN
cord-336510-qzm9wgde	654	9	-	-	HYPH
cord-336510-qzm9wgde	654	10	independent	independent	JJ
cord-336510-qzm9wgde	654	11	production	production	NN
cord-336510-qzm9wgde	654	12	of	of	IN
cord-336510-qzm9wgde	654	13	interleukin	interleukin	NN
cord-336510-qzm9wgde	654	14	12	12	CD
cord-336510-qzm9wgde	654	15	by	by	IN
cord-336510-qzm9wgde	654	16	dendritic	dendritic	JJ
cord-336510-qzm9wgde	654	17	cells	cell	NNS
cord-336510-qzm9wgde	654	18	and	and	CC
cord-336510-qzm9wgde	654	19	their	-PRON-	PRP$
cord-336510-qzm9wgde	654	20	redistribution	redistribution	NN
cord-336510-qzm9wgde	654	21	to	to	IN
cord-336510-qzm9wgde	654	22	T	t	NN
cord-336510-qzm9wgde	654	23	cell	cell	NN
cord-336510-qzm9wgde	654	24	areas	area	NNS
cord-336510-qzm9wgde	655	1	Interleukin-12	Interleukin-12	NNP
cord-336510-qzm9wgde	655	2	and	and	CC
cord-336510-qzm9wgde	655	3	the	the	DT
cord-336510-qzm9wgde	655	4	regulation	regulation	NN
cord-336510-qzm9wgde	655	5	of	of	IN
cord-336510-qzm9wgde	655	6	innate	innate	JJ
cord-336510-qzm9wgde	655	7	resistance	resistance	NN
cord-336510-qzm9wgde	655	8	and	and	CC
cord-336510-qzm9wgde	655	9	adaptive	adaptive	JJ
cord-336510-qzm9wgde	655	10	immunity	immunity	NN
cord-336510-qzm9wgde	656	1	The	the	DT
cord-336510-qzm9wgde	656	2	reciprocal	reciprocal	JJ
cord-336510-qzm9wgde	656	3	interaction	interaction	NN
cord-336510-qzm9wgde	656	4	of	of	IN
cord-336510-qzm9wgde	656	5	NK	NK	NNP
cord-336510-qzm9wgde	656	6	cells	cell	NNS
cord-336510-qzm9wgde	656	7	with	with	IN
cord-336510-qzm9wgde	656	8	plasmacytoid	plasmacytoid	NNP
cord-336510-qzm9wgde	656	9	or	or	CC
cord-336510-qzm9wgde	656	10	Novel	Novel	NNP
cord-336510-qzm9wgde	656	11	p19	p19	NN
cord-336510-qzm9wgde	656	12	protein	protein	NN
cord-336510-qzm9wgde	656	13	engages	engage	VBZ
cord-336510-qzm9wgde	656	14	IL-12p40	IL-12p40	NNP
cord-336510-qzm9wgde	656	15	to	to	TO
cord-336510-qzm9wgde	656	16	form	form	VB
cord-336510-qzm9wgde	656	17	a	a	DT
cord-336510-qzm9wgde	656	18	cytokine	cytokine	NN
cord-336510-qzm9wgde	656	19	,	,	,
cord-336510-qzm9wgde	656	20	IL-23	IL-23	NNP
cord-336510-qzm9wgde	656	21	,	,	,
cord-336510-qzm9wgde	656	22	with	with	IN
cord-336510-qzm9wgde	656	23	biological	biological	JJ
cord-336510-qzm9wgde	656	24	activities	activity	NNS
cord-336510-qzm9wgde	656	25	similar	similar	JJ
cord-336510-qzm9wgde	656	26	as	as	RB
cord-336510-qzm9wgde	656	27	well	well	RB
cord-336510-qzm9wgde	656	28	as	as	IN
cord-336510-qzm9wgde	656	29	distinct	distinct	JJ
cord-336510-qzm9wgde	656	30	from	from	IN
cord-336510-qzm9wgde	656	31	IL-12	IL-12	NNP
cord-336510-qzm9wgde	656	32	Herpes	Herpes	NNP
cord-336510-qzm9wgde	656	33	simplex	simplex	NN
cord-336510-qzm9wgde	656	34	virus	virus	NN
cord-336510-qzm9wgde	656	35	type	type	NN
cord-336510-qzm9wgde	656	36	1	1	CD
cord-336510-qzm9wgde	656	37	infection	infection	NN
cord-336510-qzm9wgde	656	38	induces	induce	VBZ
cord-336510-qzm9wgde	656	39	upregulation	upregulation	NN
cord-336510-qzm9wgde	656	40	of	of	IN
cord-336510-qzm9wgde	656	41	interleukin-23	interleukin-23	NN
cord-336510-qzm9wgde	656	42	(	(	-LRB-
cord-336510-qzm9wgde	656	43	p19	p19	NN
cord-336510-qzm9wgde	656	44	)	)	-RRB-
cord-336510-qzm9wgde	656	45	mRNA	mrna	NN
cord-336510-qzm9wgde	656	46	expression	expression	NN
cord-336510-qzm9wgde	656	47	in	in	IN
cord-336510-qzm9wgde	656	48	trigeminal	trigeminal	JJ
cord-336510-qzm9wgde	656	49	ganglia	ganglion	NNS
cord-336510-qzm9wgde	656	50	of	of	IN
cord-336510-qzm9wgde	656	51	BALB	BALB	NNP
cord-336510-qzm9wgde	656	52	/	/	SYM
cord-336510-qzm9wgde	656	53	c	c	NN
cord-336510-qzm9wgde	656	54	mice	mouse	NNS
cord-336510-qzm9wgde	656	55	IL-12	IL-12	NNP
cord-336510-qzm9wgde	656	56	and	and	CC
cord-336510-qzm9wgde	656	57	IL-23	IL-23	NNP
cord-336510-qzm9wgde	656	58	:	:	:
cord-336510-qzm9wgde	656	59	master	master	NN
cord-336510-qzm9wgde	656	60	regulators	regulator	NNS
cord-336510-qzm9wgde	656	61	of	of	IN
cord-336510-qzm9wgde	656	62	innate	innate	JJ
cord-336510-qzm9wgde	656	63	and	and	CC
cord-336510-qzm9wgde	656	64	adaptive	adaptive	JJ
cord-336510-qzm9wgde	656	65	immunity	immunity	NN
cord-336510-qzm9wgde	656	66	IL-27	IL-27	NNP
cord-336510-qzm9wgde	656	67	,	,	,
cord-336510-qzm9wgde	656	68	a	a	DT
cord-336510-qzm9wgde	656	69	heterodimeric	heterodimeric	JJ
cord-336510-qzm9wgde	656	70	cytokine	cytokine	NN
cord-336510-qzm9wgde	656	71	composed	compose	VBN
cord-336510-qzm9wgde	656	72	of	of	IN
cord-336510-qzm9wgde	656	73	EBI3	EBI3	NNP
cord-336510-qzm9wgde	656	74	and	and	CC
cord-336510-qzm9wgde	656	75	p28	p28	CD
cord-336510-qzm9wgde	656	76	protein	protein	NN
cord-336510-qzm9wgde	656	77	,	,	,
cord-336510-qzm9wgde	656	78	induces	induce	VBZ
cord-336510-qzm9wgde	656	79	proliferation	proliferation	NN
cord-336510-qzm9wgde	656	80	of	of	IN
cord-336510-qzm9wgde	656	81	naive	naive	JJ
cord-336510-qzm9wgde	656	82	CD4(+	CD4(+	NNS
cord-336510-qzm9wgde	656	83	)	)	-RRB-
cord-336510-qzm9wgde	657	1	T	T	NNP
cord-336510-qzm9wgde	657	2	cells	cell	NNS
cord-336510-qzm9wgde	657	3	Mice	mouse	NNS
cord-336510-qzm9wgde	657	4	lacking	lack	VBG
cord-336510-qzm9wgde	657	5	IL-12	il-12	PRP
cord-336510-qzm9wgde	657	6	develop	develop	VB
cord-336510-qzm9wgde	657	7	polarized	polarize	VBN
cord-336510-qzm9wgde	657	8	Th1	th1	NN
cord-336510-qzm9wgde	657	9	cells	cell	NNS
cord-336510-qzm9wgde	657	10	during	during	IN
cord-336510-qzm9wgde	657	11	viral	viral	JJ
cord-336510-qzm9wgde	657	12	infection	infection	NN
cord-336510-qzm9wgde	657	13	Effects	effect	NNS
cord-336510-qzm9wgde	657	14	of	of	IN
cord-336510-qzm9wgde	657	15	IL-12	IL-12	NNP
cord-336510-qzm9wgde	657	16	and	and	CC
cord-336510-qzm9wgde	657	17	IL-23	IL-23	NNP
cord-336510-qzm9wgde	657	18	on	on	IN
cord-336510-qzm9wgde	657	19	antigen	antigen	NN
cord-336510-qzm9wgde	657	20	-	-	HYPH
cord-336510-qzm9wgde	657	21	presenting	present	VBG
cord-336510-qzm9wgde	657	22	cells	cell	NNS
cord-336510-qzm9wgde	657	23	at	at	IN
cord-336510-qzm9wgde	657	24	the	the	DT
cord-336510-qzm9wgde	657	25	interface	interface	NN
cord-336510-qzm9wgde	657	26	between	between	IN
cord-336510-qzm9wgde	657	27	innate	innate	JJ
cord-336510-qzm9wgde	657	28	and	and	CC
cord-336510-qzm9wgde	657	29	adaptive	adaptive	JJ
cord-336510-qzm9wgde	657	30	immunity	immunity	NN
cord-336510-qzm9wgde	657	31	IL-12	IL-12	''
cord-336510-qzm9wgde	657	32	:	:	:
cord-336510-qzm9wgde	658	1	the	the	DT
cord-336510-qzm9wgde	658	2	role	role	NN
cord-336510-qzm9wgde	658	3	of	of	IN
cord-336510-qzm9wgde	658	4	p40	p40	NN
cord-336510-qzm9wgde	658	5	versus	versus	IN
cord-336510-qzm9wgde	658	6	p75	p75	NNP
cord-336510-qzm9wgde	658	7	Novel	Novel	NNP
cord-336510-qzm9wgde	658	8	IL-12	IL-12	NNP
cord-336510-qzm9wgde	658	9	family	family	NN
cord-336510-qzm9wgde	658	10	members	member	NNS
cord-336510-qzm9wgde	658	11	shed	shed	VBP
cord-336510-qzm9wgde	658	12	light	light	NN
cord-336510-qzm9wgde	658	13	on	on	IN
cord-336510-qzm9wgde	658	14	the	the	DT
cord-336510-qzm9wgde	658	15	orchestration	orchestration	NN
cord-336510-qzm9wgde	658	16	of	of	IN
cord-336510-qzm9wgde	658	17	Th1	th1	NN
cord-336510-qzm9wgde	658	18	responses	response	NNS
cord-336510-qzm9wgde	658	19	Critical	critical	JJ
cord-336510-qzm9wgde	658	20	role	role	NN
cord-336510-qzm9wgde	658	21	for	for	IN
cord-336510-qzm9wgde	658	22	IL-15	IL-15	NNP
cord-336510-qzm9wgde	658	23	in	in	IN
cord-336510-qzm9wgde	658	24	innate	innate	JJ
cord-336510-qzm9wgde	658	25	immunity	immunity	NN
cord-336510-qzm9wgde	658	26	NK	nk	NN
cord-336510-qzm9wgde	658	27	and	and	CC
cord-336510-qzm9wgde	658	28	NKT	NKT	NNP
cord-336510-qzm9wgde	658	29	cell	cell	NN
cord-336510-qzm9wgde	658	30	-	-	HYPH
cord-336510-qzm9wgde	658	31	independent	independent	JJ
cord-336510-qzm9wgde	658	32	contribution	contribution	NN
cord-336510-qzm9wgde	658	33	of	of	IN
cord-336510-qzm9wgde	658	34	interleukin-15	interleukin-15	CD
cord-336510-qzm9wgde	658	35	to	to	TO
cord-336510-qzm9wgde	658	36	innate	innate	VB
cord-336510-qzm9wgde	658	37	protection	protection	NN
cord-336510-qzm9wgde	658	38	against	against	IN
cord-336510-qzm9wgde	658	39	mucosal	mucosal	JJ
cord-336510-qzm9wgde	658	40	viral	viral	JJ
cord-336510-qzm9wgde	658	41	infection	infection	NN
cord-336510-qzm9wgde	658	42	IL-23	IL-23	NNP
cord-336510-qzm9wgde	658	43	induces	induce	VBZ
cord-336510-qzm9wgde	658	44	stronger	strong	JJR
cord-336510-qzm9wgde	658	45	sustained	sustain	VBD
cord-336510-qzm9wgde	658	46	CTL	CTL	NNP
cord-336510-qzm9wgde	658	47	and	and	CC
cord-336510-qzm9wgde	658	48	Th1	th1	NN
cord-336510-qzm9wgde	658	49	immune	immune	JJ
cord-336510-qzm9wgde	658	50	responses	response	NNS
cord-336510-qzm9wgde	658	51	than	than	IN
cord-336510-qzm9wgde	658	52	IL-12	IL-12	NNP
cord-336510-qzm9wgde	658	53	in	in	IN
cord-336510-qzm9wgde	658	54	hepatitis	hepatitis	NN
cord-336510-qzm9wgde	658	55	C	C	NNP
cord-336510-qzm9wgde	658	56	virus	virus	NN
cord-336510-qzm9wgde	658	57	envelope	envelope	NN
cord-336510-qzm9wgde	658	58	protein	protein	NN
cord-336510-qzm9wgde	658	59	2	2	CD
cord-336510-qzm9wgde	658	60	DNA	dna	NN
cord-336510-qzm9wgde	658	61	immunization	immunization	NN
cord-336510-qzm9wgde	658	62	Interleukin-4	Interleukin-4	NNP
cord-336510-qzm9wgde	658	63	suppresses	suppress	VBZ
cord-336510-qzm9wgde	658	64	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	658	65	cytokine	cytokine	NN
cord-336510-qzm9wgde	658	66	gene	gene	NN
cord-336510-qzm9wgde	658	67	transcription	transcription	NN
cord-336510-qzm9wgde	658	68	in	in	IN
cord-336510-qzm9wgde	658	69	porcine	porcine	JJ
cord-336510-qzm9wgde	658	70	macrophages	macrophage	NNS
cord-336510-qzm9wgde	659	1	Interleukin-4	Interleukin-4	NNP
cord-336510-qzm9wgde	659	2	suppresses	suppress	VBZ
cord-336510-qzm9wgde	659	3	the	the	DT
cord-336510-qzm9wgde	659	4	expression	expression	NN
cord-336510-qzm9wgde	659	5	of	of	IN
cord-336510-qzm9wgde	659	6	macrophage	macrophage	NN
cord-336510-qzm9wgde	659	7	NADPH	NADPH	NNP
cord-336510-qzm9wgde	659	8	oxidase	oxidase	NN
cord-336510-qzm9wgde	659	9	heavy	heavy	JJ
cord-336510-qzm9wgde	659	10	chain	chain	NN
cord-336510-qzm9wgde	659	11	subunit	subunit	NN
cord-336510-qzm9wgde	659	12	(	(	-LRB-
cord-336510-qzm9wgde	659	13	gp91-phox	gp91-phox	NNP
cord-336510-qzm9wgde	659	14	)	)	-RRB-
cord-336510-qzm9wgde	659	15	Mechanism	Mechanism	NNP
cord-336510-qzm9wgde	659	16	of	of	IN
cord-336510-qzm9wgde	659	17	suppression	suppression	NN
cord-336510-qzm9wgde	659	18	of	of	IN
cord-336510-qzm9wgde	659	19	nitric	nitric	JJ
cord-336510-qzm9wgde	659	20	oxide	oxide	NN
cord-336510-qzm9wgde	659	21	synthase	synthase	NN
cord-336510-qzm9wgde	659	22	expression	expression	NN
cord-336510-qzm9wgde	659	23	by	by	IN
cord-336510-qzm9wgde	659	24	interleukin-4	interleukin-4	NNP
cord-336510-qzm9wgde	659	25	in	in	IN
cord-336510-qzm9wgde	659	26	primary	primary	JJ
cord-336510-qzm9wgde	659	27	mouse	mouse	NN
cord-336510-qzm9wgde	659	28	macrophages	macrophage	NNS
cord-336510-qzm9wgde	659	29	Effect	effect	NN
cord-336510-qzm9wgde	659	30	of	of	IN
cord-336510-qzm9wgde	659	31	IL-4	IL-4	NNP
cord-336510-qzm9wgde	659	32	and	and	CC
cord-336510-qzm9wgde	659	33	IL-13	IL-13	NNP
cord-336510-qzm9wgde	659	34	on	on	IN
cord-336510-qzm9wgde	659	35	IFN	IFN	NNP
cord-336510-qzm9wgde	659	36	-	-	HYPH
cord-336510-qzm9wgde	659	37	gamma	gamma	NN
cord-336510-qzm9wgde	659	38	-	-	HYPH
cord-336510-qzm9wgde	659	39	induced	induce	VBN
cord-336510-qzm9wgde	659	40	production	production	NN
cord-336510-qzm9wgde	659	41	of	of	IN
cord-336510-qzm9wgde	659	42	nitric	nitric	JJ
cord-336510-qzm9wgde	659	43	oxide	oxide	NN
cord-336510-qzm9wgde	659	44	in	in	IN
cord-336510-qzm9wgde	659	45	mouse	mouse	NN
cord-336510-qzm9wgde	659	46	macrophages	macrophage	NNS
cord-336510-qzm9wgde	659	47	infected	infect	VBN
cord-336510-qzm9wgde	659	48	with	with	IN
cord-336510-qzm9wgde	659	49	herpes	herpes	NNP
cord-336510-qzm9wgde	659	50	simplex	simplex	NNP
cord-336510-qzm9wgde	659	51	virus	virus	NN
cord-336510-qzm9wgde	659	52	type	type	NN
cord-336510-qzm9wgde	659	53	2	2	CD
cord-336510-qzm9wgde	659	54	Heterogeneity	heterogeneity	NN
cord-336510-qzm9wgde	659	55	of	of	IN
cord-336510-qzm9wgde	659	56	helper	helper	NN
cord-336510-qzm9wgde	659	57	/	/	SYM
cord-336510-qzm9wgde	659	58	inducer	inducer	NN
cord-336510-qzm9wgde	659	59	T	t	NN
cord-336510-qzm9wgde	659	60	lymphocytes	lymphocyte	NNS
cord-336510-qzm9wgde	659	61	.	.	.
cord-336510-qzm9wgde	660	1	I.	I.	NNP
cord-336510-qzm9wgde	660	2	Lymphokine	Lymphokine	NNP
cord-336510-qzm9wgde	660	3	production	production	NN
cord-336510-qzm9wgde	660	4	and	and	CC
cord-336510-qzm9wgde	660	5	lymphokine	lymphokine	NN
cord-336510-qzm9wgde	660	6	responsiveness	responsiveness	NN
cord-336510-qzm9wgde	661	1	Mouse	mouse	NN
cord-336510-qzm9wgde	661	2	splenic	splenic	NN
cord-336510-qzm9wgde	661	3	and	and	CC
cord-336510-qzm9wgde	661	4	bone	bone	NN
cord-336510-qzm9wgde	661	5	marrow	marrow	NN
cord-336510-qzm9wgde	661	6	cell	cell	NN
cord-336510-qzm9wgde	661	7	populations	population	NNS
cord-336510-qzm9wgde	661	8	that	that	WDT
cord-336510-qzm9wgde	661	9	express	express	VBP
cord-336510-qzm9wgde	661	10	high	high	JJ
cord-336510-qzm9wgde	661	11	-	-	HYPH
cord-336510-qzm9wgde	661	12	affinity	affinity	NN
cord-336510-qzm9wgde	661	13	Fc	Fc	NNP
cord-336510-qzm9wgde	661	14	epsilon	epsilon	NN
cord-336510-qzm9wgde	661	15	receptors	receptor	NNS
cord-336510-qzm9wgde	661	16	and	and	CC
cord-336510-qzm9wgde	661	17	produce	produce	VB
cord-336510-qzm9wgde	661	18	interleukin	interleukin	NN
cord-336510-qzm9wgde	661	19	4	4	CD
cord-336510-qzm9wgde	661	20	are	be	VBP
cord-336510-qzm9wgde	661	21	highly	highly	RB
cord-336510-qzm9wgde	661	22	enriched	enrich	VBN
cord-336510-qzm9wgde	661	23	in	in	IN
cord-336510-qzm9wgde	661	24	basophils	basophil	NNS
cord-336510-qzm9wgde	661	25	Alternative	alternative	JJ
cord-336510-qzm9wgde	661	26	activation	activation	NN
cord-336510-qzm9wgde	661	27	of	of	IN
cord-336510-qzm9wgde	661	28	macrophages	macrophage	NNS
cord-336510-qzm9wgde	661	29	Differential	differential	JJ
cord-336510-qzm9wgde	661	30	responses	response	NNS
cord-336510-qzm9wgde	661	31	of	of	IN
cord-336510-qzm9wgde	661	32	human	human	JJ
cord-336510-qzm9wgde	661	33	monocytes	monocyte	NNS
cord-336510-qzm9wgde	661	34	and	and	CC
cord-336510-qzm9wgde	661	35	macrophages	macrophage	NNS
cord-336510-qzm9wgde	661	36	to	to	IN
cord-336510-qzm9wgde	662	1	IL-4	IL-4	NNP
cord-336510-qzm9wgde	662	2	and	and	CC
cord-336510-qzm9wgde	662	3	IL-13	IL-13	NNP
cord-336510-qzm9wgde	662	4	Identification	Identification	NNP
cord-336510-qzm9wgde	662	5	of	of	IN
cord-336510-qzm9wgde	662	6	a	a	DT
cord-336510-qzm9wgde	662	7	T	T	NNP
cord-336510-qzm9wgde	662	8	cell	cell	NN
cord-336510-qzm9wgde	662	9	-	-	HYPH
cord-336510-qzm9wgde	662	10	derived	derive	VBN
cord-336510-qzm9wgde	662	11	B	b	NN
cord-336510-qzm9wgde	662	12	cell	cell	NN
cord-336510-qzm9wgde	662	13	growth	growth	NN
cord-336510-qzm9wgde	662	14	factor	factor	NN
cord-336510-qzm9wgde	662	15	distinct	distinct	JJ
cord-336510-qzm9wgde	662	16	from	from	IN
cord-336510-qzm9wgde	662	17	interleukin	interleukin	NN
cord-336510-qzm9wgde	662	18	2	2	CD
cord-336510-qzm9wgde	662	19	Recombinant	recombinant	JJ
cord-336510-qzm9wgde	662	20	herpes	herpes	NN
cord-336510-qzm9wgde	662	21	simplex	simplex	NN
cord-336510-qzm9wgde	662	22	virus	virus	NN
cord-336510-qzm9wgde	662	23	type	type	NN
cord-336510-qzm9wgde	662	24	1	1	CD
cord-336510-qzm9wgde	662	25	expressing	express	VBG
cord-336510-qzm9wgde	662	26	murine	murine	JJ
cord-336510-qzm9wgde	662	27	interleukin-4	interleukin-4	NNP
cord-336510-qzm9wgde	662	28	is	be	VBZ
cord-336510-qzm9wgde	662	29	less	less	RBR
cord-336510-qzm9wgde	662	30	virulent	virulent	JJ
cord-336510-qzm9wgde	662	31	than	than	IN
cord-336510-qzm9wgde	662	32	wild	wild	JJ
cord-336510-qzm9wgde	662	33	-	-	HYPH
cord-336510-qzm9wgde	662	34	type	type	NN
cord-336510-qzm9wgde	662	35	virus	virus	NN
cord-336510-qzm9wgde	662	36	in	in	IN
cord-336510-qzm9wgde	662	37	mice	mouse	NNS
cord-336510-qzm9wgde	663	1	The	the	DT
cord-336510-qzm9wgde	663	2	effect	effect	NN
cord-336510-qzm9wgde	663	3	of	of	IN
cord-336510-qzm9wgde	663	4	UV	uv	NN
cord-336510-qzm9wgde	663	5	-	-	HYPH
cord-336510-qzm9wgde	663	6	B	b	NN
cord-336510-qzm9wgde	663	7	irradiation	irradiation	NN
cord-336510-qzm9wgde	663	8	on	on	IN
cord-336510-qzm9wgde	663	9	primary	primary	JJ
cord-336510-qzm9wgde	663	10	and	and	CC
cord-336510-qzm9wgde	663	11	secondary	secondary	JJ
cord-336510-qzm9wgde	663	12	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	663	13	infections	infection	NNS
cord-336510-qzm9wgde	663	14	in	in	IN
cord-336510-qzm9wgde	663	15	interleukin-4	interleukin-4	NNP
cord-336510-qzm9wgde	663	16	knockout	knockout	NN
cord-336510-qzm9wgde	663	17	mice	mouse	NNS
cord-336510-qzm9wgde	663	18	Role	role	NN
cord-336510-qzm9wgde	663	19	of	of	IN
cord-336510-qzm9wgde	663	20	macrophages	macrophage	NNS
cord-336510-qzm9wgde	663	21	in	in	IN
cord-336510-qzm9wgde	663	22	natural	natural	JJ
cord-336510-qzm9wgde	663	23	resistance	resistance	NN
cord-336510-qzm9wgde	663	24	to	to	IN
cord-336510-qzm9wgde	663	25	virus	virus	NN
cord-336510-qzm9wgde	663	26	infections	infection	NNS
cord-336510-qzm9wgde	663	27	Resistance	resistance	NN
cord-336510-qzm9wgde	663	28	to	to	IN
cord-336510-qzm9wgde	663	29	herpes	herpes	NN
cord-336510-qzm9wgde	663	30	simplex	simplex	NNP
cord-336510-qzm9wgde	663	31	virus	virus	NN
cord-336510-qzm9wgde	664	1	-type	-type	CD
cord-336510-qzm9wgde	664	2	1	1	CD
cord-336510-qzm9wgde	665	1	(	(	-LRB-
cord-336510-qzm9wgde	665	2	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	665	3	)	)	-RRB-
cord-336510-qzm9wgde	666	1	Immunobiology	immunobiology	NN
cord-336510-qzm9wgde	666	2	of	of	IN
cord-336510-qzm9wgde	666	3	infection	infection	NN
cord-336510-qzm9wgde	666	4	with	with	IN
cord-336510-qzm9wgde	666	5	herpes	herpes	NN
cord-336510-qzm9wgde	666	6	simplex	simplex	NNP
cord-336510-qzm9wgde	666	7	virus	virus	NN
cord-336510-qzm9wgde	666	8	Role	role	NN
cord-336510-qzm9wgde	666	9	of	of	IN
cord-336510-qzm9wgde	666	10	macrophages	macrophage	NNS
cord-336510-qzm9wgde	666	11	in	in	IN
cord-336510-qzm9wgde	666	12	hepatitis	hepatitis	NN
cord-336510-qzm9wgde	666	13	induced	induce	VBN
cord-336510-qzm9wgde	666	14	by	by	IN
cord-336510-qzm9wgde	666	15	herpes	herpes	NNP
cord-336510-qzm9wgde	666	16	simplex	simplex	NNP
cord-336510-qzm9wgde	666	17	virus	virus	NN
cord-336510-qzm9wgde	666	18	type	type	NN
cord-336510-qzm9wgde	666	19	1	1	CD
cord-336510-qzm9wgde	666	20	and	and	CC
cord-336510-qzm9wgde	666	21	2	2	CD
cord-336510-qzm9wgde	666	22	in	in	IN
cord-336510-qzm9wgde	666	23	mice	mouse	NNS
cord-336510-qzm9wgde	666	24	Re	re	NN
cord-336510-qzm9wgde	666	25	-	-	,
cord-336510-qzm9wgde	666	26	evaluating	evaluate	VBG
cord-336510-qzm9wgde	666	27	natural	natural	JJ
cord-336510-qzm9wgde	666	28	resistance	resistance	NN
cord-336510-qzm9wgde	666	29	to	to	IN
cord-336510-qzm9wgde	666	30	herpes	herpes	NNP
cord-336510-qzm9wgde	667	1	simplex	simplex	NNP
cord-336510-qzm9wgde	667	2	virus	virus	NN
cord-336510-qzm9wgde	667	3	type	type	NN
cord-336510-qzm9wgde	667	4	1	1	CD
cord-336510-qzm9wgde	667	5	Macrophages	macrophage	NNS
cord-336510-qzm9wgde	667	6	and	and	CC
cord-336510-qzm9wgde	667	7	age	age	NN
cord-336510-qzm9wgde	667	8	-	-	HYPH
cord-336510-qzm9wgde	667	9	dependent	dependent	JJ
cord-336510-qzm9wgde	667	10	resistance	resistance	NN
cord-336510-qzm9wgde	667	11	to	to	IN
cord-336510-qzm9wgde	667	12	hepatitis	hepatitis	NN
cord-336510-qzm9wgde	667	13	induced	induce	VBN
cord-336510-qzm9wgde	667	14	by	by	IN
cord-336510-qzm9wgde	667	15	herpes	herpes	NNP
cord-336510-qzm9wgde	667	16	simplex	simplex	NNP
cord-336510-qzm9wgde	667	17	virus	virus	NN
cord-336510-qzm9wgde	667	18	type	type	NN
cord-336510-qzm9wgde	667	19	2	2	CD
cord-336510-qzm9wgde	667	20	in	in	IN
cord-336510-qzm9wgde	667	21	mice	mouse	NNS
cord-336510-qzm9wgde	668	1	Experimental	experimental	JJ
cord-336510-qzm9wgde	668	2	infection	infection	NN
cord-336510-qzm9wgde	668	3	of	of	IN
cord-336510-qzm9wgde	668	4	inbred	inbred	JJ
cord-336510-qzm9wgde	668	5	mice	mouse	NNS
cord-336510-qzm9wgde	668	6	with	with	IN
cord-336510-qzm9wgde	668	7	herpes	herpes	NN
cord-336510-qzm9wgde	668	8	simplex	simplex	NNP
cord-336510-qzm9wgde	668	9	virus	virus	NN
cord-336510-qzm9wgde	668	10	.	.	.
cord-336510-qzm9wgde	669	1	III	III	NNP
cord-336510-qzm9wgde	669	2	.	.	.
cord-336510-qzm9wgde	670	1	Comparison	comparison	NN
cord-336510-qzm9wgde	670	2	between	between	IN
cord-336510-qzm9wgde	670	3	newborn	newborn	JJ
cord-336510-qzm9wgde	670	4	and	and	CC
cord-336510-qzm9wgde	670	5	adult	adult	NN
cord-336510-qzm9wgde	670	6	C57BL/6	C57BL/6	NNP
cord-336510-qzm9wgde	670	7	mice	mouse	NNS
cord-336510-qzm9wgde	670	8	Genetics	genetic	NNS
cord-336510-qzm9wgde	670	9	of	of	IN
cord-336510-qzm9wgde	670	10	natural	natural	JJ
cord-336510-qzm9wgde	670	11	resistance	resistance	NN
cord-336510-qzm9wgde	670	12	to	to	IN
cord-336510-qzm9wgde	670	13	herpesvirus	herpesvirus	NN
cord-336510-qzm9wgde	670	14	infections	infection	NNS
cord-336510-qzm9wgde	670	15	in	in	IN
cord-336510-qzm9wgde	670	16	mice	mice	NN
cord-336510-qzm9wgde	670	17	Genetics	genetic	NNS
cord-336510-qzm9wgde	670	18	of	of	IN
cord-336510-qzm9wgde	670	19	macrophage	macrophage	NN
cord-336510-qzm9wgde	670	20	-	-	HYPH
cord-336510-qzm9wgde	670	21	controled	control	VBN
cord-336510-qzm9wgde	670	22	resistance	resistance	NN
cord-336510-qzm9wgde	670	23	to	to	IN
cord-336510-qzm9wgde	670	24	hepatitis	hepatitis	NN
cord-336510-qzm9wgde	670	25	induced	induce	VBN
cord-336510-qzm9wgde	670	26	by	by	IN
cord-336510-qzm9wgde	670	27	herpes	herpes	NNP
cord-336510-qzm9wgde	670	28	simplex	simplex	NNP
cord-336510-qzm9wgde	670	29	virus	virus	NN
cord-336510-qzm9wgde	670	30	type	type	NN
cord-336510-qzm9wgde	670	31	2	2	CD
cord-336510-qzm9wgde	670	32	in	in	IN
cord-336510-qzm9wgde	670	33	mice	mouse	NNS
cord-336510-qzm9wgde	671	1	An	an	DT
cord-336510-qzm9wgde	671	2	Xlinked	Xlinked	NNP
cord-336510-qzm9wgde	671	3	locus	locus	NN
cord-336510-qzm9wgde	671	4	influences	influence	VBZ
cord-336510-qzm9wgde	671	5	the	the	DT
cord-336510-qzm9wgde	671	6	amount	amount	NN
cord-336510-qzm9wgde	671	7	of	of	IN
cord-336510-qzm9wgde	671	8	circulating	circulate	VBG
cord-336510-qzm9wgde	671	9	interferon	interferon	NN
cord-336510-qzm9wgde	671	10	induced	induce	VBN
cord-336510-qzm9wgde	671	11	in	in	IN
cord-336510-qzm9wgde	671	12	the	the	DT
cord-336510-qzm9wgde	671	13	mouse	mouse	NN
cord-336510-qzm9wgde	671	14	by	by	IN
cord-336510-qzm9wgde	671	15	herpes	herpes	NNP
cord-336510-qzm9wgde	671	16	simplex	simplex	NNP
cord-336510-qzm9wgde	671	17	virus	virus	NN
cord-336510-qzm9wgde	671	18	type	type	NN
cord-336510-qzm9wgde	671	19	1	1	CD
cord-336510-qzm9wgde	671	20	X	x	NN
cord-336510-qzm9wgde	671	21	-	-	HYPH
cord-336510-qzm9wgde	671	22	linked	link	VBN
cord-336510-qzm9wgde	671	23	resistance	resistance	NN
cord-336510-qzm9wgde	671	24	of	of	IN
cord-336510-qzm9wgde	671	25	mice	mouse	NNS
cord-336510-qzm9wgde	671	26	to	to	IN
cord-336510-qzm9wgde	671	27	high	high	JJ
cord-336510-qzm9wgde	671	28	doses	dose	NNS
cord-336510-qzm9wgde	671	29	of	of	IN
cord-336510-qzm9wgde	671	30	herpes	herpes	NNP
cord-336510-qzm9wgde	671	31	simplex	simplex	NNP
cord-336510-qzm9wgde	671	32	virus	virus	NN
cord-336510-qzm9wgde	671	33	type	type	NN
cord-336510-qzm9wgde	671	34	2	2	CD
cord-336510-qzm9wgde	671	35	correlates	correlate	VBZ
cord-336510-qzm9wgde	671	36	with	with	IN
cord-336510-qzm9wgde	671	37	early	early	JJ
cord-336510-qzm9wgde	671	38	interferon	interferon	NN
cord-336510-qzm9wgde	671	39	production	production	NN
cord-336510-qzm9wgde	671	40	Role	role	NN
cord-336510-qzm9wgde	671	41	of	of	IN
cord-336510-qzm9wgde	671	42	interferon	interferon	NN
cord-336510-qzm9wgde	671	43	in	in	IN
cord-336510-qzm9wgde	671	44	the	the	DT
cord-336510-qzm9wgde	671	45	pathogenesis	pathogenesis	NN
cord-336510-qzm9wgde	671	46	of	of	IN
cord-336510-qzm9wgde	671	47	virus	virus	NN
cord-336510-qzm9wgde	671	48	diseases	disease	NNS
cord-336510-qzm9wgde	671	49	in	in	IN
cord-336510-qzm9wgde	671	50	mice	mouse	NNS
cord-336510-qzm9wgde	671	51	as	as	IN
cord-336510-qzm9wgde	671	52	demonstrated	demonstrate	VBN
cord-336510-qzm9wgde	671	53	by	by	IN
cord-336510-qzm9wgde	671	54	the	the	DT
cord-336510-qzm9wgde	671	55	use	use	NN
cord-336510-qzm9wgde	671	56	of	of	IN
cord-336510-qzm9wgde	671	57	anti	anti	JJ
cord-336510-qzm9wgde	671	58	-	-	JJ
cord-336510-qzm9wgde	671	59	interferon	interferon	JJ
cord-336510-qzm9wgde	671	60	serum	serum	NN
cord-336510-qzm9wgde	671	61	Effect	effect	NN
cord-336510-qzm9wgde	671	62	of	of	IN
cord-336510-qzm9wgde	671	63	mercuric	mercuric	NN
cord-336510-qzm9wgde	671	64	chloride	chloride	NN
cord-336510-qzm9wgde	671	65	on	on	IN
cord-336510-qzm9wgde	671	66	macrophage	macrophage	NN
cord-336510-qzm9wgde	671	67	-	-	HYPH
cord-336510-qzm9wgde	671	68	mediated	mediate	VBN
cord-336510-qzm9wgde	671	69	resistance	resistance	NN
cord-336510-qzm9wgde	671	70	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	671	71	against	against	IN
cord-336510-qzm9wgde	671	72	infection	infection	NN
cord-336510-qzm9wgde	671	73	with	with	IN
cord-336510-qzm9wgde	671	74	herpes	herpes	NNP
cord-336510-qzm9wgde	671	75	simplex	simplex	NNP
cord-336510-qzm9wgde	671	76	virus	virus	NN
cord-336510-qzm9wgde	671	77	type	type	NN
cord-336510-qzm9wgde	671	78	2	2	CD
cord-336510-qzm9wgde	671	79	Influence	influence	NN
cord-336510-qzm9wgde	671	80	of	of	IN
cord-336510-qzm9wgde	671	81	mercuric	mercuric	NN
cord-336510-qzm9wgde	671	82	chloride	chloride	NN
cord-336510-qzm9wgde	671	83	on	on	IN
cord-336510-qzm9wgde	671	84	resistance	resistance	NN
cord-336510-qzm9wgde	671	85	to	to	IN
cord-336510-qzm9wgde	671	86	generalized	generalized	JJ
cord-336510-qzm9wgde	671	87	infection	infection	NN
cord-336510-qzm9wgde	671	88	with	with	IN
cord-336510-qzm9wgde	671	89	herpes	herpes	NN
cord-336510-qzm9wgde	671	90	simplex	simplex	NNP
cord-336510-qzm9wgde	671	91	virus	virus	NN
cord-336510-qzm9wgde	671	92	type	type	NN
cord-336510-qzm9wgde	671	93	2	2	CD
cord-336510-qzm9wgde	671	94	in	in	IN
cord-336510-qzm9wgde	671	95	mice	mouse	NNS
cord-336510-qzm9wgde	671	96	Innate	innate	JJ
cord-336510-qzm9wgde	671	97	and	and	CC
cord-336510-qzm9wgde	671	98	acquired	acquire	VBD
cord-336510-qzm9wgde	671	99	immunity	immunity	NN
cord-336510-qzm9wgde	671	100	to	to	IN
cord-336510-qzm9wgde	671	101	herpes	herpes	NNP
cord-336510-qzm9wgde	671	102	simplex	simplex	NNP
cord-336510-qzm9wgde	671	103	virus	virus	NN
cord-336510-qzm9wgde	671	104	type	type	NN
cord-336510-qzm9wgde	671	105	1	1	CD
cord-336510-qzm9wgde	671	106	Ectopic	ectopic	JJ
cord-336510-qzm9wgde	671	107	expression	expression	NN
cord-336510-qzm9wgde	671	108	of	of	IN
cord-336510-qzm9wgde	671	109	DNA	dna	NN
cord-336510-qzm9wgde	671	110	encoding	encoding	NN
cord-336510-qzm9wgde	671	111	IFN	IFN	NNP
cord-336510-qzm9wgde	671	112	-	-	HYPH
cord-336510-qzm9wgde	671	113	alpha	alpha	NNP
cord-336510-qzm9wgde	671	114	1	1	CD
cord-336510-qzm9wgde	671	115	in	in	IN
cord-336510-qzm9wgde	671	116	the	the	DT
cord-336510-qzm9wgde	671	117	cornea	cornea	NN
cord-336510-qzm9wgde	671	118	protects	protect	VBZ
cord-336510-qzm9wgde	671	119	mice	mouse	NNS
cord-336510-qzm9wgde	671	120	from	from	IN
cord-336510-qzm9wgde	671	121	herpes	herpes	NNP
cord-336510-qzm9wgde	671	122	simplex	simplex	NNP
cord-336510-qzm9wgde	671	123	virus	virus	NN
cord-336510-qzm9wgde	671	124	type	type	NN
cord-336510-qzm9wgde	671	125	1-induced	1-induced	CD
cord-336510-qzm9wgde	671	126	encephalitis	encephalitis	NN
cord-336510-qzm9wgde	671	127	Virgin	Virgin	NNP
cord-336510-qzm9wgde	671	128	HW	HW	NNP
cord-336510-qzm9wgde	671	129	:	:	:
cord-336510-qzm9wgde	672	1	Interferons	interferon	NNS
cord-336510-qzm9wgde	672	2	regulate	regulate	VBP
cord-336510-qzm9wgde	672	3	the	the	DT
cord-336510-qzm9wgde	672	4	phenotype	phenotype	NN
cord-336510-qzm9wgde	672	5	of	of	IN
cord-336510-qzm9wgde	672	6	wild	wild	JJ
cord-336510-qzm9wgde	672	7	-	-	HYPH
cord-336510-qzm9wgde	672	8	type	type	NN
cord-336510-qzm9wgde	672	9	and	and	CC
cord-336510-qzm9wgde	672	10	mutant	mutant	JJ
cord-336510-qzm9wgde	672	11	herpes	herpes	NN
cord-336510-qzm9wgde	672	12	simplex	simplex	NN
cord-336510-qzm9wgde	672	13	viruses	virus	NNS
cord-336510-qzm9wgde	672	14	in	in	IN
cord-336510-qzm9wgde	672	15	vivo	vivo	NN
cord-336510-qzm9wgde	672	16	Neural	neural	JJ
cord-336510-qzm9wgde	672	17	infection	infection	NN
cord-336510-qzm9wgde	672	18	in	in	IN
cord-336510-qzm9wgde	672	19	mice	mouse	NNS
cord-336510-qzm9wgde	672	20	after	after	IN
cord-336510-qzm9wgde	672	21	cutaneous	cutaneous	JJ
cord-336510-qzm9wgde	672	22	inoculation	inoculation	NN
cord-336510-qzm9wgde	672	23	with	with	IN
cord-336510-qzm9wgde	672	24	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	672	25	is	be	VBZ
cord-336510-qzm9wgde	672	26	under	under	IN
cord-336510-qzm9wgde	672	27	complex	complex	JJ
cord-336510-qzm9wgde	672	28	host	host	NN
cord-336510-qzm9wgde	672	29	genetic	genetic	JJ
cord-336510-qzm9wgde	672	30	control	control	NN
cord-336510-qzm9wgde	673	1	Multiple	multiple	JJ
cord-336510-qzm9wgde	673	2	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	673	3	for	for	IN
cord-336510-qzm9wgde	673	4	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	673	5	induction	induction	NN
cord-336510-qzm9wgde	673	6	of	of	IN
cord-336510-qzm9wgde	673	7	interferon	interferon	NN
cord-336510-qzm9wgde	673	8	alpha	alpha	NN
cord-336510-qzm9wgde	673	9	production	production	NN
cord-336510-qzm9wgde	673	10	by	by	IN
cord-336510-qzm9wgde	673	11	peripheral	peripheral	JJ
cord-336510-qzm9wgde	673	12	blood	blood	NN
cord-336510-qzm9wgde	673	13	mononuclear	mononuclear	NN
cord-336510-qzm9wgde	673	14	cells	cell	NNS
cord-336510-qzm9wgde	674	1	Autocrine	Autocrine	NNP
cord-336510-qzm9wgde	674	2	secretion	secretion	NN
cord-336510-qzm9wgde	674	3	of	of	IN
cord-336510-qzm9wgde	674	4	interferon	interferon	NN
cord-336510-qzm9wgde	674	5	-	-	HYPH
cord-336510-qzm9wgde	674	6	alpha/	alpha/	NN
cord-336510-qzm9wgde	674	7	beta	beta	NN
cord-336510-qzm9wgde	674	8	and	and	CC
cord-336510-qzm9wgde	674	9	tumour	tumour	NN
cord-336510-qzm9wgde	674	10	necrosis	necrosis	NN
cord-336510-qzm9wgde	674	11	factor	factor	NN
cord-336510-qzm9wgde	674	12	-	-	HYPH
cord-336510-qzm9wgde	674	13	alpha	alpha	NN
cord-336510-qzm9wgde	674	14	synergistically	synergistically	RB
cord-336510-qzm9wgde	674	15	activates	activate	VBZ
cord-336510-qzm9wgde	674	16	mouse	mouse	NN
cord-336510-qzm9wgde	674	17	macrophages	macrophage	NNS
cord-336510-qzm9wgde	674	18	after	after	IN
cord-336510-qzm9wgde	674	19	infection	infection	NN
cord-336510-qzm9wgde	674	20	with	with	IN
cord-336510-qzm9wgde	674	21	herpes	herpes	NNP
cord-336510-qzm9wgde	674	22	simplex	simplex	NNP
cord-336510-qzm9wgde	674	23	virus	virus	NN
cord-336510-qzm9wgde	674	24	type	type	NN
cord-336510-qzm9wgde	674	25	2	2	CD
cord-336510-qzm9wgde	674	26	Herpes	Herpes	NNP
cord-336510-qzm9wgde	674	27	Simplex	Simplex	NNP
cord-336510-qzm9wgde	674	28	virus	virus	NN
cord-336510-qzm9wgde	674	29	type	type	NN
cord-336510-qzm9wgde	674	30	1-induced	1-induced	CD
cord-336510-qzm9wgde	674	31	interferon	interferon	NN
cord-336510-qzm9wgde	674	32	production	production	NN
cord-336510-qzm9wgde	674	33	and	and	CC
cord-336510-qzm9wgde	674	34	activation	activation	NN
cord-336510-qzm9wgde	674	35	of	of	IN
cord-336510-qzm9wgde	674	36	natural	natural	JJ
cord-336510-qzm9wgde	674	37	killer	killer	NN
cord-336510-qzm9wgde	674	38	cells	cell	NNS
cord-336510-qzm9wgde	674	39	in	in	IN
cord-336510-qzm9wgde	674	40	mice	mouse	NNS
cord-336510-qzm9wgde	675	1	Transient	transient	JJ
cord-336510-qzm9wgde	675	2	IFNgamma	IFNgamma	NNP
cord-336510-qzm9wgde	675	3	synthesis	synthesis	NN
cord-336510-qzm9wgde	675	4	in	in	IN
cord-336510-qzm9wgde	675	5	the	the	DT
cord-336510-qzm9wgde	675	6	lymph	lymph	NN
cord-336510-qzm9wgde	675	7	node	node	NN
cord-336510-qzm9wgde	675	8	draining	drain	VBG
cord-336510-qzm9wgde	675	9	a	a	DT
cord-336510-qzm9wgde	675	10	dermal	dermal	JJ
cord-336510-qzm9wgde	675	11	site	site	NN
cord-336510-qzm9wgde	675	12	loaded	load	VBN
cord-336510-qzm9wgde	675	13	with	with	IN
cord-336510-qzm9wgde	675	14	UV	uv	NN
cord-336510-qzm9wgde	675	15	-	-	HYPH
cord-336510-qzm9wgde	675	16	irradiated	irradiate	VBN
cord-336510-qzm9wgde	675	17	herpes	herpes	NN
cord-336510-qzm9wgde	675	18	simplex	simplex	NN
cord-336510-qzm9wgde	675	19	virus	virus	NN
cord-336510-qzm9wgde	675	20	type	type	NN
cord-336510-qzm9wgde	675	21	1	1	CD
cord-336510-qzm9wgde	675	22	:	:	:
cord-336510-qzm9wgde	675	23	an	an	DT
cord-336510-qzm9wgde	675	24	NK	NK	NNP
cord-336510-qzm9wgde	675	25	-	-	:
cord-336510-qzm9wgde	675	26	and	and	CC
cord-336510-qzm9wgde	675	27	CD3-dependent	cd3-dependent	NN
cord-336510-qzm9wgde	675	28	process	process	NN
cord-336510-qzm9wgde	675	29	regulated	regulate	VBN
cord-336510-qzm9wgde	675	30	by	by	IN
cord-336510-qzm9wgde	675	31	IL-12	IL-12	NNP
cord-336510-qzm9wgde	675	32	but	but	CC
cord-336510-qzm9wgde	675	33	not	not	RB
cord-336510-qzm9wgde	675	34	by	by	IN
cord-336510-qzm9wgde	675	35	IFN	IFN	NNP
cord-336510-qzm9wgde	675	36	-	-	HYPH
cord-336510-qzm9wgde	675	37	alpha	alpha	NN
cord-336510-qzm9wgde	675	38	/	/	SYM
cord-336510-qzm9wgde	675	39	beta	beta	NN
cord-336510-qzm9wgde	675	40	Inhibition	Inhibition	NNP
cord-336510-qzm9wgde	675	41	of	of	IN
cord-336510-qzm9wgde	675	42	herpes	herpes	NNP
cord-336510-qzm9wgde	675	43	simplex	simplex	NNP
cord-336510-qzm9wgde	675	44	virus	virus	NN
cord-336510-qzm9wgde	675	45	type	type	NN
cord-336510-qzm9wgde	675	46	1-induced	1-induced	CD
cord-336510-qzm9wgde	676	1	interferon	interferon	NNP
cord-336510-qzm9wgde	676	2	synthesis	synthesis	NN
cord-336510-qzm9wgde	676	3	by	by	IN
cord-336510-qzm9wgde	676	4	monoclonal	monoclonal	JJ
cord-336510-qzm9wgde	676	5	antibodies	antibody	NNS
cord-336510-qzm9wgde	676	6	against	against	IN
cord-336510-qzm9wgde	676	7	viral	viral	JJ
cord-336510-qzm9wgde	676	8	glycoprotein	glycoprotein	NN
cord-336510-qzm9wgde	676	9	D	d	NN
cord-336510-qzm9wgde	676	10	and	and	CC
cord-336510-qzm9wgde	676	11	by	by	IN
cord-336510-qzm9wgde	676	12	lysosomotropic	lysosomotropic	JJ
cord-336510-qzm9wgde	676	13	drugs	drug	NNS
cord-336510-qzm9wgde	676	14	Viral	viral	JJ
cord-336510-qzm9wgde	676	15	activation	activation	NN
cord-336510-qzm9wgde	676	16	of	of	IN
cord-336510-qzm9wgde	676	17	macrophages	macrophage	NNS
cord-336510-qzm9wgde	676	18	through	through	IN
cord-336510-qzm9wgde	676	19	TLR	tlr	NN
cord-336510-qzm9wgde	676	20	-	-	HYPH
cord-336510-qzm9wgde	676	21	dependent	dependent	JJ
cord-336510-qzm9wgde	676	22	and	and	CC
cord-336510-qzm9wgde	676	23	-independent	-independent	JJ
cord-336510-qzm9wgde	676	24	pathways	pathway	NNS
cord-336510-qzm9wgde	677	1	The	the	DT
cord-336510-qzm9wgde	677	2	mannose	mannose	NN
cord-336510-qzm9wgde	677	3	receptor	receptor	NN
cord-336510-qzm9wgde	677	4	mediates	mediate	VBZ
cord-336510-qzm9wgde	677	5	induction	induction	NN
cord-336510-qzm9wgde	677	6	of	of	IN
cord-336510-qzm9wgde	677	7	IFN	IFN	NNP
cord-336510-qzm9wgde	677	8	-	-	HYPH
cord-336510-qzm9wgde	677	9	alpha	alpha	NN
cord-336510-qzm9wgde	677	10	in	in	IN
cord-336510-qzm9wgde	677	11	peripheral	peripheral	JJ
cord-336510-qzm9wgde	677	12	blood	blood	NN
cord-336510-qzm9wgde	677	13	dendritic	dendritic	JJ
cord-336510-qzm9wgde	677	14	cells	cell	NNS
cord-336510-qzm9wgde	677	15	by	by	IN
cord-336510-qzm9wgde	677	16	enveloped	envelop	VBN
cord-336510-qzm9wgde	677	17	RNA	RNA	NNP
cord-336510-qzm9wgde	677	18	and	and	CC
cord-336510-qzm9wgde	677	19	DNA	dna	NN
cord-336510-qzm9wgde	677	20	viruses	virus	NNS
cord-336510-qzm9wgde	677	21	Reading	read	VBG
cord-336510-qzm9wgde	677	22	the	the	DT
cord-336510-qzm9wgde	677	23	viral	viral	JJ
cord-336510-qzm9wgde	677	24	signature	signature	NN
cord-336510-qzm9wgde	677	25	by	by	IN
cord-336510-qzm9wgde	677	26	Tolllike	Tolllike	NNP
cord-336510-qzm9wgde	677	27	receptors	receptor	NNS
cord-336510-qzm9wgde	677	28	and	and	CC
cord-336510-qzm9wgde	677	29	other	other	JJ
cord-336510-qzm9wgde	677	30	pattern	pattern	NN
cord-336510-qzm9wgde	677	31	recognition	recognition	NN
cord-336510-qzm9wgde	677	32	receptors	receptor	NNS
cord-336510-qzm9wgde	677	33	Toll	Toll	NNP
cord-336510-qzm9wgde	677	34	-	-	HYPH
cord-336510-qzm9wgde	677	35	like	like	JJ
cord-336510-qzm9wgde	677	36	receptor	receptor	NN
cord-336510-qzm9wgde	677	37	9-mediated	9-mediated	CD
cord-336510-qzm9wgde	677	38	recognition	recognition	NN
cord-336510-qzm9wgde	677	39	of	of	IN
cord-336510-qzm9wgde	677	40	Herpes	Herpes	NNP
cord-336510-qzm9wgde	677	41	simplex	simplex	NNP
cord-336510-qzm9wgde	677	42	virus-2	virus-2	NNP
cord-336510-qzm9wgde	677	43	by	by	IN
cord-336510-qzm9wgde	677	44	plasmacytoid	plasmacytoid	NNP
cord-336510-qzm9wgde	677	45	dendritic	dendritic	JJ
cord-336510-qzm9wgde	677	46	cells	cell	NNS
cord-336510-qzm9wgde	678	1	Herpes	Herpes	NNP
cord-336510-qzm9wgde	678	2	simplex	simplex	NN
cord-336510-qzm9wgde	678	3	virus	virus	NN
cord-336510-qzm9wgde	679	1	type-1	type-1	NN
cord-336510-qzm9wgde	679	2	induces	induce	VBZ
cord-336510-qzm9wgde	679	3	IFN	IFN	NNP
cord-336510-qzm9wgde	679	4	-	-	HYPH
cord-336510-qzm9wgde	679	5	alpha	alpha	NN
cord-336510-qzm9wgde	679	6	production	production	NN
cord-336510-qzm9wgde	679	7	via	via	IN
cord-336510-qzm9wgde	679	8	Toll	toll	NN
cord-336510-qzm9wgde	679	9	-	-	HYPH
cord-336510-qzm9wgde	679	10	like	like	JJ
cord-336510-qzm9wgde	679	11	receptor	receptor	NN
cord-336510-qzm9wgde	679	12	9-dependent	9-dependent	CD
cord-336510-qzm9wgde	679	13	and	and	CC
cord-336510-qzm9wgde	679	14	-independent	-independent	JJ
cord-336510-qzm9wgde	679	15	pathways	pathway	NNS
cord-336510-qzm9wgde	680	1	Herpes	Herpes	NNP
cord-336510-qzm9wgde	680	2	simplex	simplex	NN
cord-336510-qzm9wgde	680	3	virus	virus	NN
cord-336510-qzm9wgde	680	4	type	type	NN
cord-336510-qzm9wgde	680	5	1	1	CD
cord-336510-qzm9wgde	680	6	activates	activate	VBZ
cord-336510-qzm9wgde	680	7	murine	murine	JJ
cord-336510-qzm9wgde	680	8	natural	natural	JJ
cord-336510-qzm9wgde	680	9	interferon	interferon	NN
cord-336510-qzm9wgde	680	10	-	-	HYPH
cord-336510-qzm9wgde	680	11	producing	produce	VBG
cord-336510-qzm9wgde	680	12	cells	cell	NNS
cord-336510-qzm9wgde	680	13	through	through	IN
cord-336510-qzm9wgde	680	14	toll	toll	NN
cord-336510-qzm9wgde	680	15	-	-	HYPH
cord-336510-qzm9wgde	680	16	like	like	JJ
cord-336510-qzm9wgde	680	17	receptor	receptor	NN
cord-336510-qzm9wgde	680	18	9	9	CD
cord-336510-qzm9wgde	680	19	Viral	viral	JJ
cord-336510-qzm9wgde	680	20	infection	infection	NN
cord-336510-qzm9wgde	681	1	switches	switch	NNS
cord-336510-qzm9wgde	681	2	non	non	JJ
cord-336510-qzm9wgde	681	3	-	-	JJ
cord-336510-qzm9wgde	681	4	plasmacytoid	plasmacytoid	JJ
cord-336510-qzm9wgde	681	5	dendritic	dendritic	JJ
cord-336510-qzm9wgde	681	6	cells	cell	NNS
cord-336510-qzm9wgde	681	7	into	into	IN
cord-336510-qzm9wgde	681	8	high	high	JJ
cord-336510-qzm9wgde	681	9	interferon	interferon	NN
cord-336510-qzm9wgde	681	10	producers	producer	NNS
cord-336510-qzm9wgde	682	1	The	the	DT
cord-336510-qzm9wgde	682	2	RNA	RNA	NNP
cord-336510-qzm9wgde	682	3	helicase	helicase	NN
cord-336510-qzm9wgde	682	4	RIG	rig	NN
cord-336510-qzm9wgde	682	5	-	-	:
cord-336510-qzm9wgde	682	6	I	-PRON-	PRP
cord-336510-qzm9wgde	682	7	has	have	VBZ
cord-336510-qzm9wgde	682	8	an	an	DT
cord-336510-qzm9wgde	682	9	essential	essential	JJ
cord-336510-qzm9wgde	682	10	function	function	NN
cord-336510-qzm9wgde	682	11	in	in	IN
cord-336510-qzm9wgde	682	12	double	double	RB
cord-336510-qzm9wgde	682	13	-	-	HYPH
cord-336510-qzm9wgde	682	14	stranded	strand	VBN
cord-336510-qzm9wgde	682	15	RNA	rna	NN
cord-336510-qzm9wgde	682	16	-	-	HYPH
cord-336510-qzm9wgde	682	17	induced	induce	VBN
cord-336510-qzm9wgde	682	18	innate	innate	JJ
cord-336510-qzm9wgde	682	19	antiviral	antiviral	JJ
cord-336510-qzm9wgde	682	20	responses	response	NNS
cord-336510-qzm9wgde	682	21	Three	three	CD
cord-336510-qzm9wgde	682	22	novel	novel	JJ
cord-336510-qzm9wgde	682	23	mammalian	mammalian	JJ
cord-336510-qzm9wgde	682	24	toll	toll	NN
cord-336510-qzm9wgde	682	25	-	-	HYPH
cord-336510-qzm9wgde	682	26	like	like	JJ
cord-336510-qzm9wgde	682	27	receptors	receptor	NNS
cord-336510-qzm9wgde	682	28	:	:	:
cord-336510-qzm9wgde	682	29	gene	gene	NN
cord-336510-qzm9wgde	682	30	structure	structure	NN
cord-336510-qzm9wgde	682	31	,	,	,
cord-336510-qzm9wgde	682	32	expression	expression	NN
cord-336510-qzm9wgde	682	33	,	,	,
cord-336510-qzm9wgde	682	34	and	and	CC
cord-336510-qzm9wgde	682	35	evolution	evolution	NN
cord-336510-qzm9wgde	682	36	Species	species	NN
cord-336510-qzm9wgde	682	37	-	-	HYPH
cord-336510-qzm9wgde	682	38	specific	specific	JJ
cord-336510-qzm9wgde	682	39	recognition	recognition	NN
cord-336510-qzm9wgde	682	40	of	of	IN
cord-336510-qzm9wgde	682	41	single	single	RB
cord-336510-qzm9wgde	682	42	-	-	HYPH
cord-336510-qzm9wgde	682	43	stranded	strand	VBN
cord-336510-qzm9wgde	682	44	RNA	RNA	NNP
cord-336510-qzm9wgde	682	45	via	via	IN
cord-336510-qzm9wgde	682	46	toll	toll	NN
cord-336510-qzm9wgde	682	47	-	-	HYPH
cord-336510-qzm9wgde	682	48	like	like	JJ
cord-336510-qzm9wgde	682	49	receptor	receptor	NN
cord-336510-qzm9wgde	682	50	7	7	CD
cord-336510-qzm9wgde	682	51	and	and	CC
cord-336510-qzm9wgde	682	52	8	8	CD
cord-336510-qzm9wgde	682	53	Toll	toll	NN
cord-336510-qzm9wgde	682	54	-	-	HYPH
cord-336510-qzm9wgde	682	55	like	like	JJ
cord-336510-qzm9wgde	682	56	receptors	receptor	NNS
cord-336510-qzm9wgde	682	57	in	in	IN
cord-336510-qzm9wgde	682	58	innate	innate	JJ
cord-336510-qzm9wgde	682	59	immunity	immunity	NN
cord-336510-qzm9wgde	682	60	Positive	positive	JJ
cord-336510-qzm9wgde	682	61	feedback	feedback	NN
cord-336510-qzm9wgde	682	62	regulation	regulation	NN
cord-336510-qzm9wgde	682	63	of	of	IN
cord-336510-qzm9wgde	682	64	type	type	NN
cord-336510-qzm9wgde	683	1	I	-PRON-	PRP
cord-336510-qzm9wgde	683	2	IFN	IFN	NNP
cord-336510-qzm9wgde	683	3	genes	gene	NNS
cord-336510-qzm9wgde	683	4	by	by	IN
cord-336510-qzm9wgde	683	5	the	the	DT
cord-336510-qzm9wgde	683	6	IFNinducible	ifninducible	JJ
cord-336510-qzm9wgde	683	7	transcription	transcription	NN
cord-336510-qzm9wgde	683	8	factor	factor	NN
cord-336510-qzm9wgde	683	9	IRF-7	IRF-7	NNP
cord-336510-qzm9wgde	683	10	Regulation	regulation	NN
cord-336510-qzm9wgde	683	11	of	of	IN
cord-336510-qzm9wgde	683	12	IFN	IFN	NNP
cord-336510-qzm9wgde	683	13	regulatory	regulatory	JJ
cord-336510-qzm9wgde	683	14	factor-7	factor-7	NNP
cord-336510-qzm9wgde	683	15	and	and	CC
cord-336510-qzm9wgde	683	16	IFN	IFN	NNP
cord-336510-qzm9wgde	683	17	-	-	HYPH
cord-336510-qzm9wgde	683	18	alpha	alpha	NN
cord-336510-qzm9wgde	683	19	production	production	NN
cord-336510-qzm9wgde	683	20	by	by	IN
cord-336510-qzm9wgde	683	21	enveloped	envelop	VBN
cord-336510-qzm9wgde	683	22	virus	virus	NN
cord-336510-qzm9wgde	683	23	and	and	CC
cord-336510-qzm9wgde	683	24	lipopolysaccharide	lipopolysaccharide	NN
cord-336510-qzm9wgde	683	25	in	in	IN
cord-336510-qzm9wgde	683	26	human	human	JJ
cord-336510-qzm9wgde	683	27	plasmacytoid	plasmacytoid	NN
cord-336510-qzm9wgde	683	28	dendritic	dendritic	JJ
cord-336510-qzm9wgde	683	29	cells	cell	NNS
cord-336510-qzm9wgde	684	1	The	the	DT
cord-336510-qzm9wgde	684	2	effect	effect	NN
cord-336510-qzm9wgde	684	3	of	of	IN
cord-336510-qzm9wgde	684	4	priming	prime	VBG
cord-336510-qzm9wgde	684	5	with	with	IN
cord-336510-qzm9wgde	684	6	interferon	interferon	NN
cord-336510-qzm9wgde	684	7	on	on	IN
cord-336510-qzm9wgde	684	8	interferon	interferon	NN
cord-336510-qzm9wgde	684	9	production	production	NN
cord-336510-qzm9wgde	684	10	by	by	IN
cord-336510-qzm9wgde	684	11	two	two	CD
cord-336510-qzm9wgde	684	12	lines	line	NNS
cord-336510-qzm9wgde	684	13	of	of	IN
cord-336510-qzm9wgde	684	14	L	L	NNP
cord-336510-qzm9wgde	684	15	cells	cell	NNS
cord-336510-qzm9wgde	684	16	Studies	study	NNS
cord-336510-qzm9wgde	684	17	on	on	IN
cord-336510-qzm9wgde	684	18	expression	expression	NN
cord-336510-qzm9wgde	684	19	of	of	IN
cord-336510-qzm9wgde	684	20	spontaneous	spontaneous	JJ
cord-336510-qzm9wgde	684	21	and	and	CC
cord-336510-qzm9wgde	684	22	induced	induced	JJ
cord-336510-qzm9wgde	684	23	interferons	interferon	NNS
cord-336510-qzm9wgde	684	24	in	in	IN
cord-336510-qzm9wgde	684	25	mouse	mouse	NN
cord-336510-qzm9wgde	684	26	peritoneal	peritoneal	NN
cord-336510-qzm9wgde	684	27	macrophages	macrophage	NNS
cord-336510-qzm9wgde	684	28	by	by	IN
cord-336510-qzm9wgde	684	29	means	mean	NNS
cord-336510-qzm9wgde	684	30	of	of	IN
cord-336510-qzm9wgde	684	31	monoclonal	monoclonal	JJ
cord-336510-qzm9wgde	684	32	antibodies	antibody	NNS
cord-336510-qzm9wgde	684	33	to	to	TO
cord-336510-qzm9wgde	684	34	mouse	mouse	VB
cord-336510-qzm9wgde	684	35	interferons	interferon	NNS
cord-336510-qzm9wgde	684	36	Injection	injection	NN
cord-336510-qzm9wgde	684	37	of	of	IN
cord-336510-qzm9wgde	684	38	mice	mouse	NNS
cord-336510-qzm9wgde	684	39	with	with	IN
cord-336510-qzm9wgde	684	40	antibody	antibody	NN
cord-336510-qzm9wgde	684	41	to	to	TO
cord-336510-qzm9wgde	684	42	mouse	mouse	VB
cord-336510-qzm9wgde	684	43	interferon	interferon	NNP
cord-336510-qzm9wgde	684	44	alpha	alpha	NN
cord-336510-qzm9wgde	684	45	/	/	SYM
cord-336510-qzm9wgde	684	46	beta	beta	NN
cord-336510-qzm9wgde	684	47	decreases	decrease	VBZ
cord-336510-qzm9wgde	684	48	the	the	DT
cord-336510-qzm9wgde	684	49	level	level	NN
cord-336510-qzm9wgde	684	50	of	of	IN
cord-336510-qzm9wgde	684	51	2'-5	2'-5	NNP
cord-336510-qzm9wgde	684	52	'	'	POS
cord-336510-qzm9wgde	684	53	oligoadenylate	oligoadenylate	NN
cord-336510-qzm9wgde	684	54	synthetase	synthetase	NN
cord-336510-qzm9wgde	684	55	in	in	IN
cord-336510-qzm9wgde	684	56	peritoneal	peritoneal	JJ
cord-336510-qzm9wgde	684	57	macrophages	macrophage	NNS
cord-336510-qzm9wgde	685	1	Specific	specific	JJ
cord-336510-qzm9wgde	685	2	interferon	interferon	NN
cord-336510-qzm9wgde	685	3	genes	gene	NNS
cord-336510-qzm9wgde	685	4	are	be	VBP
cord-336510-qzm9wgde	685	5	expressed	express	VBN
cord-336510-qzm9wgde	685	6	in	in	IN
cord-336510-qzm9wgde	685	7	individual	individual	JJ
cord-336510-qzm9wgde	685	8	cells	cell	NNS
cord-336510-qzm9wgde	685	9	in	in	IN
cord-336510-qzm9wgde	685	10	the	the	DT
cord-336510-qzm9wgde	685	11	peritoneum	peritoneum	NN
cord-336510-qzm9wgde	685	12	and	and	CC
cord-336510-qzm9wgde	685	13	bone	bone	NN
cord-336510-qzm9wgde	685	14	marrow	marrow	NN
cord-336510-qzm9wgde	685	15	of	of	IN
cord-336510-qzm9wgde	685	16	normal	normal	JJ
cord-336510-qzm9wgde	685	17	mice	mouse	NNS
cord-336510-qzm9wgde	685	18	Inhibition	inhibition	NN
cord-336510-qzm9wgde	685	19	by	by	IN
cord-336510-qzm9wgde	685	20	interleukin-4	interleukin-4	NNP
cord-336510-qzm9wgde	685	21	of	of	IN
cord-336510-qzm9wgde	685	22	constitutive	constitutive	JJ
cord-336510-qzm9wgde	685	23	beta	beta	NN
cord-336510-qzm9wgde	685	24	interferon	interferon	NN
cord-336510-qzm9wgde	685	25	synthesis	synthesis	NN
cord-336510-qzm9wgde	685	26	in	in	IN
cord-336510-qzm9wgde	685	27	mouse	mouse	NN
cord-336510-qzm9wgde	685	28	macrophages	macrophage	NNS
cord-336510-qzm9wgde	685	29	Genetically	genetically	RB
cord-336510-qzm9wgde	685	30	determined	determine	VBN
cord-336510-qzm9wgde	685	31	difference	difference	NN
cord-336510-qzm9wgde	685	32	in	in	IN
cord-336510-qzm9wgde	685	33	the	the	DT
cord-336510-qzm9wgde	685	34	antiviral	antiviral	JJ
cord-336510-qzm9wgde	685	35	action	action	NN
cord-336510-qzm9wgde	685	36	of	of	IN
cord-336510-qzm9wgde	685	37	alpha	alpha	NN
cord-336510-qzm9wgde	685	38	/	/	SYM
cord-336510-qzm9wgde	685	39	beta	beta	NN
cord-336510-qzm9wgde	685	40	interferon	interferon	NN
cord-336510-qzm9wgde	685	41	in	in	IN
cord-336510-qzm9wgde	685	42	cells	cell	NNS
cord-336510-qzm9wgde	685	43	from	from	IN
cord-336510-qzm9wgde	685	44	mice	mouse	NNS
cord-336510-qzm9wgde	685	45	resistant	resistant	JJ
cord-336510-qzm9wgde	685	46	or	or	CC
cord-336510-qzm9wgde	685	47	susceptible	susceptible	JJ
cord-336510-qzm9wgde	685	48	to	to	IN
cord-336510-qzm9wgde	685	49	herpes	herpes	NN
cord-336510-qzm9wgde	685	50	simplex	simplex	NNP
cord-336510-qzm9wgde	685	51	virus	virus	NN
cord-336510-qzm9wgde	685	52	type	type	NN
cord-336510-qzm9wgde	686	1	2	2	CD
cord-336510-qzm9wgde	686	2	Genetic	genetic	JJ
cord-336510-qzm9wgde	686	3	control	control	NN
cord-336510-qzm9wgde	686	4	of	of	IN
cord-336510-qzm9wgde	686	5	the	the	DT
cord-336510-qzm9wgde	686	6	innate	innate	JJ
cord-336510-qzm9wgde	686	7	immune	immune	JJ
cord-336510-qzm9wgde	686	8	response	response	NN
cord-336510-qzm9wgde	686	9	Signaling	signal	VBG
cord-336510-qzm9wgde	686	10	to	to	IN
cord-336510-qzm9wgde	686	11	NF	NF	NNP
cord-336510-qzm9wgde	686	12	-	-	HYPH
cord-336510-qzm9wgde	686	13	kappaB	kappaB	NNP
cord-336510-qzm9wgde	686	14	NF	NF	NNP
cord-336510-qzm9wgde	686	15	-	-	HYPH
cord-336510-qzm9wgde	686	16	kappaB	kappaB	NNP
cord-336510-qzm9wgde	686	17	activation	activation	NN
cord-336510-qzm9wgde	686	18	is	be	VBZ
cord-336510-qzm9wgde	686	19	responsible	responsible	JJ
cord-336510-qzm9wgde	686	20	for	for	IN
cord-336510-qzm9wgde	686	21	the	the	DT
cord-336510-qzm9wgde	686	22	synergistic	synergistic	JJ
cord-336510-qzm9wgde	686	23	effect	effect	NN
cord-336510-qzm9wgde	686	24	of	of	IN
cord-336510-qzm9wgde	686	25	herpes	herpes	NNP
cord-336510-qzm9wgde	686	26	simplex	simplex	NNP
cord-336510-qzm9wgde	686	27	virus	virus	NN
cord-336510-qzm9wgde	686	28	type	type	NN
cord-336510-qzm9wgde	686	29	2	2	CD
cord-336510-qzm9wgde	686	30	infection	infection	NN
cord-336510-qzm9wgde	686	31	on	on	IN
cord-336510-qzm9wgde	686	32	interferon	interferon	NN
cord-336510-qzm9wgde	686	33	-	-	HYPH
cord-336510-qzm9wgde	686	34	gamma	gamma	NN
cord-336510-qzm9wgde	686	35	-	-	HYPH
cord-336510-qzm9wgde	686	36	induced	induce	VBN
cord-336510-qzm9wgde	686	37	nitric	nitric	NN
cord-336510-qzm9wgde	686	38	oxide	oxide	NN
cord-336510-qzm9wgde	686	39	production	production	NN
cord-336510-qzm9wgde	686	40	in	in	IN
cord-336510-qzm9wgde	686	41	macrophages	macrophage	NNS
cord-336510-qzm9wgde	686	42	Virus	virus	NN
cord-336510-qzm9wgde	686	43	-	-	HYPH
cord-336510-qzm9wgde	686	44	cell	cell	NN
cord-336510-qzm9wgde	686	45	interactions	interaction	NNS
cord-336510-qzm9wgde	686	46	regulating	regulate	VBG
cord-336510-qzm9wgde	686	47	induction	induction	NN
cord-336510-qzm9wgde	686	48	of	of	IN
cord-336510-qzm9wgde	686	49	tumor	tumor	NN
cord-336510-qzm9wgde	686	50	necrosis	necrosis	NN
cord-336510-qzm9wgde	686	51	factor	factor	NN
cord-336510-qzm9wgde	686	52	alpha	alpha	NN
cord-336510-qzm9wgde	686	53	production	production	NN
cord-336510-qzm9wgde	686	54	in	in	IN
cord-336510-qzm9wgde	686	55	macrophages	macrophage	NNS
cord-336510-qzm9wgde	686	56	infected	infect	VBN
cord-336510-qzm9wgde	686	57	with	with	IN
cord-336510-qzm9wgde	686	58	herpes	herpes	NN
cord-336510-qzm9wgde	686	59	simplex	simplex	NNP
cord-336510-qzm9wgde	686	60	virus	virus	NN
cord-336510-qzm9wgde	686	61	Tumor	tumor	NN
cord-336510-qzm9wgde	686	62	necrosis	necrosis	NN
cord-336510-qzm9wgde	686	63	factor	factor	NN
cord-336510-qzm9wgde	686	64	acts	act	VBZ
cord-336510-qzm9wgde	686	65	synergistically	synergistically	RB
cord-336510-qzm9wgde	686	66	with	with	IN
cord-336510-qzm9wgde	686	67	autocrine	autocrine	JJ
cord-336510-qzm9wgde	686	68	interferon	interferon	NN
cord-336510-qzm9wgde	686	69	-	-	HYPH
cord-336510-qzm9wgde	686	70	beta	beta	NN
cord-336510-qzm9wgde	686	71	and	and	CC
cord-336510-qzm9wgde	686	72	increases	increase	NNS
cord-336510-qzm9wgde	687	1	interferon	interferon	NN
cord-336510-qzm9wgde	687	2	-	-	HYPH
cord-336510-qzm9wgde	687	3	beta	beta	NN
cord-336510-qzm9wgde	687	4	mRNA	mRNA	NNP
cord-336510-qzm9wgde	687	5	levels	level	NNS
cord-336510-qzm9wgde	687	6	in	in	IN
cord-336510-qzm9wgde	687	7	human	human	JJ
cord-336510-qzm9wgde	687	8	fibroblasts	fibroblast	NNS
cord-336510-qzm9wgde	687	9	Is	be	VBZ
cord-336510-qzm9wgde	687	10	Wiskott	Wiskott	NNP
cord-336510-qzm9wgde	687	11	-	-	HYPH
cord-336510-qzm9wgde	687	12	Aldrich	Aldrich	NNP
cord-336510-qzm9wgde	687	13	syndrome	syndrome	NN
cord-336510-qzm9wgde	687	14	a	a	DT
cord-336510-qzm9wgde	687	15	cell	cell	NN
cord-336510-qzm9wgde	687	16	trafficking	traffic	VBG
cord-336510-qzm9wgde	687	17	disorder	disorder	NN
cord-336510-qzm9wgde	687	18	?	?	.
cord-336510-qzm9wgde	688	1	The	the	DT
cord-336510-qzm9wgde	688	2	Wiskott	Wiskott	NNP
cord-336510-qzm9wgde	688	3	-	-	HYPH
cord-336510-qzm9wgde	688	4	Aldrich	Aldrich	NNP
cord-336510-qzm9wgde	688	5	syndrome	syndrome	NN
cord-336510-qzm9wgde	688	6	Natural	natural	JJ
cord-336510-qzm9wgde	688	7	killer	killer	NN
cord-336510-qzm9wgde	688	8	cell	cell	NN
cord-336510-qzm9wgde	688	9	function	function	NN
cord-336510-qzm9wgde	688	10	and	and	CC
cord-336510-qzm9wgde	688	11	interferon	interferon	NN
cord-336510-qzm9wgde	688	12	generation	generation	NN
cord-336510-qzm9wgde	688	13	in	in	IN
cord-336510-qzm9wgde	688	14	patients	patient	NNS
cord-336510-qzm9wgde	688	15	with	with	IN
cord-336510-qzm9wgde	688	16	primary	primary	JJ
cord-336510-qzm9wgde	688	17	immunodeficiencies	immunodeficiency	NNS
cord-336510-qzm9wgde	688	18	Functional	functional	JJ
cord-336510-qzm9wgde	688	19	defects	defect	NNS
cord-336510-qzm9wgde	688	20	of	of	IN
cord-336510-qzm9wgde	688	21	dendritic	dendritic	JJ
cord-336510-qzm9wgde	688	22	cells	cell	NNS
cord-336510-qzm9wgde	688	23	in	in	IN
cord-336510-qzm9wgde	688	24	patients	patient	NNS
cord-336510-qzm9wgde	688	25	with	with	IN
cord-336510-qzm9wgde	688	26	CD40	CD40	NNP
cord-336510-qzm9wgde	688	27	deficiency	deficiency	NN
cord-336510-qzm9wgde	689	1	CD40	cd40	JJ
cord-336510-qzm9wgde	689	2	and	and	CC
cord-336510-qzm9wgde	689	3	dendritic	dendritic	JJ
cord-336510-qzm9wgde	689	4	cell	cell	NN
cord-336510-qzm9wgde	689	5	function	function	NN
cord-336510-qzm9wgde	689	6	Distinctive	distinctive	JJ
cord-336510-qzm9wgde	689	7	roles	role	NNS
cord-336510-qzm9wgde	689	8	for	for	IN
cord-336510-qzm9wgde	689	9	2',5'-oligoadenylate	2',5'-oligoadenylate	CD
cord-336510-qzm9wgde	689	10	synthetases	synthetase	NNS
cord-336510-qzm9wgde	689	11	and	and	CC
cord-336510-qzm9wgde	689	12	double	double	RB
cord-336510-qzm9wgde	689	13	-	-	HYPH
cord-336510-qzm9wgde	689	14	stranded	strand	VBN
cord-336510-qzm9wgde	689	15	RNA	rna	NN
cord-336510-qzm9wgde	689	16	-	-	HYPH
cord-336510-qzm9wgde	689	17	dependent	dependent	JJ
cord-336510-qzm9wgde	689	18	protein	protein	NN
cord-336510-qzm9wgde	689	19	kinase	kinase	NN
cord-336510-qzm9wgde	689	20	R	r	NN
cord-336510-qzm9wgde	689	21	in	in	IN
cord-336510-qzm9wgde	689	22	the	the	DT
cord-336510-qzm9wgde	689	23	in	in	IN
cord-336510-qzm9wgde	689	24	vivo	vivo	NN
cord-336510-qzm9wgde	689	25	antiviral	antiviral	JJ
cord-336510-qzm9wgde	689	26	effect	effect	NN
cord-336510-qzm9wgde	689	27	of	of	IN
cord-336510-qzm9wgde	689	28	an	an	DT
cord-336510-qzm9wgde	689	29	adenoviral	adenoviral	JJ
cord-336510-qzm9wgde	689	30	vector	vector	NN
cord-336510-qzm9wgde	689	31	expressing	express	VBG
cord-336510-qzm9wgde	689	32	murine	murine	JJ
cord-336510-qzm9wgde	689	33	IFN	IFN	NNP
cord-336510-qzm9wgde	689	34	-	-	HYPH
cord-336510-qzm9wgde	689	35	beta	beta	NNP
cord-336510-qzm9wgde	689	36	Promyelocytic	Promyelocytic	NNP
cord-336510-qzm9wgde	689	37	leukemia	leukemia	NN
cord-336510-qzm9wgde	689	38	protein	protein	NN
cord-336510-qzm9wgde	689	39	mediates	mediate	VBZ
cord-336510-qzm9wgde	689	40	interferon	interferon	NN
cord-336510-qzm9wgde	689	41	-	-	HYPH
cord-336510-qzm9wgde	689	42	based	base	VBN
cord-336510-qzm9wgde	689	43	anti	anti	JJ
cord-336510-qzm9wgde	689	44	-	-	JJ
cord-336510-qzm9wgde	689	45	herpes	herpes	JJ
cord-336510-qzm9wgde	689	46	simplex	simplex	NN
cord-336510-qzm9wgde	689	47	virus	virus	NN
cord-336510-qzm9wgde	689	48	1	1	CD
cord-336510-qzm9wgde	689	49	effects	effect	NNS
cord-336510-qzm9wgde	689	50	Mouse	mouse	NN
cord-336510-qzm9wgde	689	51	genes	gene	NNS
cord-336510-qzm9wgde	689	52	influence	influence	VBP
cord-336510-qzm9wgde	689	53	antiviral	antiviral	JJ
cord-336510-qzm9wgde	689	54	action	action	NN
cord-336510-qzm9wgde	689	55	of	of	IN
cord-336510-qzm9wgde	689	56	interferon	interferon	NN
cord-336510-qzm9wgde	689	57	in	in	IN
cord-336510-qzm9wgde	689	58	vivo	vivo	NN
cord-336510-qzm9wgde	689	59	Differential	differential	JJ
cord-336510-qzm9wgde	689	60	sensitivity	sensitivity	NN
cord-336510-qzm9wgde	689	61	of	of	IN
cord-336510-qzm9wgde	689	62	macrophages	macrophage	NNS
cord-336510-qzm9wgde	689	63	from	from	IN
cord-336510-qzm9wgde	689	64	herpes	herpes	NNP
cord-336510-qzm9wgde	689	65	simplex	simplex	NNP
cord-336510-qzm9wgde	689	66	virus	virus	NN
cord-336510-qzm9wgde	689	67	-	-	HYPH
cord-336510-qzm9wgde	689	68	resistant	resistant	JJ
cord-336510-qzm9wgde	689	69	and	and	CC
cord-336510-qzm9wgde	689	70	-susceptible	-susceptible	JJ
cord-336510-qzm9wgde	689	71	mice	mouse	NNS
cord-336510-qzm9wgde	689	72	to	to	IN
cord-336510-qzm9wgde	689	73	respiratory	respiratory	JJ
cord-336510-qzm9wgde	689	74	burst	burst	NN
cord-336510-qzm9wgde	689	75	priming	prime	VBG
cord-336510-qzm9wgde	689	76	by	by	IN
cord-336510-qzm9wgde	689	77	interferon	interferon	NN
cord-336510-qzm9wgde	689	78	-	-	HYPH
cord-336510-qzm9wgde	689	79	alpha	alpha	NN
cord-336510-qzm9wgde	689	80	/	/	SYM
cord-336510-qzm9wgde	689	81	beta	beta	NN
cord-336510-qzm9wgde	689	82	Antiviral	antiviral	JJ
cord-336510-qzm9wgde	689	83	activity	activity	NN
cord-336510-qzm9wgde	689	84	of	of	IN
cord-336510-qzm9wgde	689	85	tumour	tumour	NN
cord-336510-qzm9wgde	689	86	necrosis	necrosis	NN
cord-336510-qzm9wgde	689	87	factor	factor	NN
cord-336510-qzm9wgde	689	88	.	.	.
cord-336510-qzm9wgde	690	1	Synergism	synergism	NN
cord-336510-qzm9wgde	690	2	with	with	IN
cord-336510-qzm9wgde	690	3	interferons	interferon	NNS
cord-336510-qzm9wgde	690	4	and	and	CC
cord-336510-qzm9wgde	690	5	induction	induction	NN
cord-336510-qzm9wgde	690	6	of	of	IN
cord-336510-qzm9wgde	690	7	oligo-2',5'-adenylate	oligo-2',5'-adenylate	JJ
cord-336510-qzm9wgde	690	8	synthetase	synthetase	NNP
cord-336510-qzm9wgde	690	9	Differential	Differential	NNP
cord-336510-qzm9wgde	690	10	effect	effect	NN
cord-336510-qzm9wgde	690	11	of	of	IN
cord-336510-qzm9wgde	690	12	murine	murine	JJ
cord-336510-qzm9wgde	690	13	alpha	alpha	NN
cord-336510-qzm9wgde	690	14	/	/	SYM
cord-336510-qzm9wgde	690	15	beta	beta	NN
cord-336510-qzm9wgde	690	16	interferon	interferon	NN
cord-336510-qzm9wgde	690	17	transgenes	transgene	NNS
cord-336510-qzm9wgde	690	18	on	on	IN
cord-336510-qzm9wgde	690	19	antagonization	antagonization	NN
cord-336510-qzm9wgde	690	20	of	of	IN
cord-336510-qzm9wgde	690	21	herpes	herpes	NNP
cord-336510-qzm9wgde	690	22	simplex	simplex	NNP
cord-336510-qzm9wgde	690	23	virus	virus	NN
cord-336510-qzm9wgde	690	24	type	type	NN
cord-336510-qzm9wgde	690	25	1	1	CD
cord-336510-qzm9wgde	690	26	replication	replication	NN
cord-336510-qzm9wgde	690	27	Continuous	continuous	JJ
cord-336510-qzm9wgde	690	28	production	production	NN
cord-336510-qzm9wgde	690	29	of	of	IN
cord-336510-qzm9wgde	690	30	interferon	interferon	NN
cord-336510-qzm9wgde	690	31	in	in	IN
cord-336510-qzm9wgde	690	32	normal	normal	JJ
cord-336510-qzm9wgde	690	33	mice	mouse	NNS
cord-336510-qzm9wgde	690	34	:	:	:
cord-336510-qzm9wgde	690	35	effect	effect	NN
cord-336510-qzm9wgde	690	36	of	of	IN
cord-336510-qzm9wgde	690	37	anti	anti	JJ
cord-336510-qzm9wgde	690	38	-	-	JJ
cord-336510-qzm9wgde	690	39	interferon	interferon	JJ
cord-336510-qzm9wgde	690	40	globulin	globulin	NN
cord-336510-qzm9wgde	690	41	,	,	,
cord-336510-qzm9wgde	690	42	sex	sex	NN
cord-336510-qzm9wgde	690	43	,	,	,
cord-336510-qzm9wgde	690	44	age	age	NN
cord-336510-qzm9wgde	690	45	,	,	,
cord-336510-qzm9wgde	690	46	strain	strain	NN
cord-336510-qzm9wgde	690	47	and	and	CC
cord-336510-qzm9wgde	690	48	environment	environment	NN
cord-336510-qzm9wgde	690	49	on	on	IN
cord-336510-qzm9wgde	690	50	the	the	DT
cord-336510-qzm9wgde	690	51	levels	level	NNS
cord-336510-qzm9wgde	690	52	of	of	IN
cord-336510-qzm9wgde	690	53	2	2	CD
cord-336510-qzm9wgde	690	54	-	-	HYPH
cord-336510-qzm9wgde	690	55	5A	5a	NN
cord-336510-qzm9wgde	690	56	synthetase	synthetase	NN
cord-336510-qzm9wgde	690	57	and	and	CC
cord-336510-qzm9wgde	691	1	p67	p67	NN
cord-336510-qzm9wgde	691	2	K	K	NNP
cord-336510-qzm9wgde	691	3	kinase	kinase	NN
cord-336510-qzm9wgde	692	1	The	the	DT
cord-336510-qzm9wgde	692	2	role	role	NN
cord-336510-qzm9wgde	692	3	of	of	IN
cord-336510-qzm9wgde	692	4	the	the	DT
cord-336510-qzm9wgde	692	5	UL41	UL41	NNP
cord-336510-qzm9wgde	692	6	gene	gene	NN
cord-336510-qzm9wgde	692	7	of	of	IN
cord-336510-qzm9wgde	692	8	herpes	herpes	NNP
cord-336510-qzm9wgde	692	9	simplex	simplex	NNP
cord-336510-qzm9wgde	692	10	virus	virus	NN
cord-336510-qzm9wgde	692	11	type	type	NN
cord-336510-qzm9wgde	692	12	1	1	CD
cord-336510-qzm9wgde	692	13	in	in	IN
cord-336510-qzm9wgde	692	14	evasion	evasion	NN
cord-336510-qzm9wgde	692	15	of	of	IN
cord-336510-qzm9wgde	692	16	non	non	JJ
cord-336510-qzm9wgde	692	17	-	-	JJ
cord-336510-qzm9wgde	692	18	specific	specific	JJ
cord-336510-qzm9wgde	692	19	host	host	NN
cord-336510-qzm9wgde	692	20	defence	defence	NN
cord-336510-qzm9wgde	692	21	mechanisms	mechanism	NNS
cord-336510-qzm9wgde	692	22	during	during	IN
cord-336510-qzm9wgde	692	23	primary	primary	JJ
cord-336510-qzm9wgde	692	24	infection	infection	NN
cord-336510-qzm9wgde	692	25	Induction	induction	NN
cord-336510-qzm9wgde	692	26	of	of	IN
cord-336510-qzm9wgde	692	27	suppressor	suppressor	NN
cord-336510-qzm9wgde	692	28	of	of	IN
cord-336510-qzm9wgde	692	29	cytokine	cytokine	NN
cord-336510-qzm9wgde	692	30	signaling-3	signaling-3	NNP
cord-336510-qzm9wgde	692	31	by	by	IN
cord-336510-qzm9wgde	692	32	herpes	herpes	NNP
cord-336510-qzm9wgde	692	33	simplex	simplex	NNP
cord-336510-qzm9wgde	692	34	virus	virus	NN
cord-336510-qzm9wgde	692	35	type	type	NN
cord-336510-qzm9wgde	692	36	1	1	CD
cord-336510-qzm9wgde	692	37	contributes	contribute	VBZ
cord-336510-qzm9wgde	692	38	to	to	IN
cord-336510-qzm9wgde	692	39	inhibition	inhibition	NN
cord-336510-qzm9wgde	692	40	of	of	IN
cord-336510-qzm9wgde	692	41	the	the	DT
cord-336510-qzm9wgde	692	42	interferon	interferon	NN
cord-336510-qzm9wgde	692	43	signaling	signal	VBG
cord-336510-qzm9wgde	692	44	pathway	pathway	NN
cord-336510-qzm9wgde	692	45	Herpes	Herpes	NNP
cord-336510-qzm9wgde	692	46	simplex	simplex	NN
cord-336510-qzm9wgde	692	47	virus	virus	NN
cord-336510-qzm9wgde	692	48	1	1	CD
cord-336510-qzm9wgde	692	49	gene	gene	NN
cord-336510-qzm9wgde	692	50	products	product	NNS
cord-336510-qzm9wgde	693	1	occlude	occlude	VB
cord-336510-qzm9wgde	693	2	the	the	DT
cord-336510-qzm9wgde	693	3	interferon	interferon	NN
cord-336510-qzm9wgde	693	4	signaling	signal	VBG
cord-336510-qzm9wgde	693	5	pathway	pathway	NN
cord-336510-qzm9wgde	693	6	at	at	IN
cord-336510-qzm9wgde	693	7	multiple	multiple	JJ
cord-336510-qzm9wgde	693	8	sites	site	NNS
cord-336510-qzm9wgde	693	9	Suppression	suppression	NN
cord-336510-qzm9wgde	693	10	of	of	IN
cord-336510-qzm9wgde	693	11	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	693	12	cytokine	cytokine	NN
cord-336510-qzm9wgde	693	13	expression	expression	NN
cord-336510-qzm9wgde	693	14	by	by	IN
cord-336510-qzm9wgde	693	15	herpes	herpes	NNP
cord-336510-qzm9wgde	693	16	simplex	simplex	NNP
cord-336510-qzm9wgde	693	17	virus	virus	NN
cord-336510-qzm9wgde	693	18	type	type	NN
cord-336510-qzm9wgde	693	19	1	1	CD
cord-336510-qzm9wgde	694	1	The	the	DT
cord-336510-qzm9wgde	694	2	interferon	interferon	NN
cord-336510-qzm9wgde	694	3	-	-	HYPH
cord-336510-qzm9wgde	694	4	macrophage	macrophage	NN
cord-336510-qzm9wgde	694	5	alliance	alliance	NN
cord-336510-qzm9wgde	694	6	Macrophages	macrophage	NNS
cord-336510-qzm9wgde	694	7	and	and	CC
cord-336510-qzm9wgde	694	8	other	other	JJ
cord-336510-qzm9wgde	694	9	nonspecific	nonspecific	JJ
cord-336510-qzm9wgde	694	10	defences	defence	NNS
cord-336510-qzm9wgde	694	11	:	:	:
cord-336510-qzm9wgde	694	12	Role	role	NN
cord-336510-qzm9wgde	694	13	of	of	IN
cord-336510-qzm9wgde	694	14	modulating	modulate	VBG
cord-336510-qzm9wgde	694	15	resistance	resistance	NN
cord-336510-qzm9wgde	694	16	against	against	IN
cord-336510-qzm9wgde	694	17	herpes	herpes	NNP
cord-336510-qzm9wgde	694	18	simplex	simplex	NNP
cord-336510-qzm9wgde	694	19	virus	virus	NN
cord-336510-qzm9wgde	694	20	Macrophage	macrophage	NN
cord-336510-qzm9wgde	694	21	extrinsic	extrinsic	JJ
cord-336510-qzm9wgde	694	22	antiviral	antiviral	JJ
cord-336510-qzm9wgde	694	23	activity	activity	NN
cord-336510-qzm9wgde	694	24	during	during	IN
cord-336510-qzm9wgde	694	25	herpes	herpes	NNP
cord-336510-qzm9wgde	694	26	simplex	simplex	NNP
cord-336510-qzm9wgde	694	27	virus	virus	NN
cord-336510-qzm9wgde	694	28	infection	infection	NN
cord-336510-qzm9wgde	694	29	Role	role	NN
cord-336510-qzm9wgde	694	30	of	of	IN
cord-336510-qzm9wgde	694	31	interferon	interferon	NN
cord-336510-qzm9wgde	694	32	in	in	IN
cord-336510-qzm9wgde	694	33	persistent	persistent	JJ
cord-336510-qzm9wgde	694	34	infection	infection	NN
cord-336510-qzm9wgde	694	35	of	of	IN
cord-336510-qzm9wgde	694	36	macrophages	macrophage	NNS
cord-336510-qzm9wgde	694	37	with	with	IN
cord-336510-qzm9wgde	694	38	herpes	herpes	NN
cord-336510-qzm9wgde	694	39	simplex	simplex	NN
cord-336510-qzm9wgde	694	40	virus	virus	NN
cord-336510-qzm9wgde	694	41	Possible	possible	JJ
cord-336510-qzm9wgde	694	42	role	role	NN
cord-336510-qzm9wgde	694	43	of	of	IN
cord-336510-qzm9wgde	694	44	reactive	reactive	JJ
cord-336510-qzm9wgde	694	45	oxygen	oxygen	NN
cord-336510-qzm9wgde	694	46	species	specie	NNS
cord-336510-qzm9wgde	694	47	in	in	IN
cord-336510-qzm9wgde	694	48	antiviral	antiviral	JJ
cord-336510-qzm9wgde	694	49	defense	defense	NN
cord-336510-qzm9wgde	694	50	Oxidative	oxidative	JJ
cord-336510-qzm9wgde	694	51	killing	killing	NN
cord-336510-qzm9wgde	694	52	of	of	IN
cord-336510-qzm9wgde	694	53	microbes	microbe	NNS
cord-336510-qzm9wgde	694	54	by	by	IN
cord-336510-qzm9wgde	694	55	neutrophils	neutrophil	NNS
cord-336510-qzm9wgde	694	56	Reactive	reactive	JJ
cord-336510-qzm9wgde	694	57	oxygen	oxygen	NN
cord-336510-qzm9wgde	694	58	and	and	CC
cord-336510-qzm9wgde	694	59	reactive	reactive	JJ
cord-336510-qzm9wgde	694	60	nitrogen	nitrogen	NN
cord-336510-qzm9wgde	694	61	intermediates	intermediate	NNS
cord-336510-qzm9wgde	694	62	in	in	IN
cord-336510-qzm9wgde	694	63	innate	innate	JJ
cord-336510-qzm9wgde	694	64	and	and	CC
cord-336510-qzm9wgde	694	65	specific	specific	JJ
cord-336510-qzm9wgde	694	66	immunity	immunity	NN
cord-336510-qzm9wgde	694	67	Reactive	reactive	JJ
cord-336510-qzm9wgde	694	68	oxygen	oxygen	NN
cord-336510-qzm9wgde	694	69	intermediates	intermediate	NNS
cord-336510-qzm9wgde	694	70	in	in	IN
cord-336510-qzm9wgde	694	71	TNF	TNF	NNP
cord-336510-qzm9wgde	694	72	signaling	signal	VBG
cord-336510-qzm9wgde	694	73	Molecular	molecular	JJ
cord-336510-qzm9wgde	694	74	events	event	NNS
cord-336510-qzm9wgde	694	75	associated	associate	VBN
cord-336510-qzm9wgde	694	76	with	with	IN
cord-336510-qzm9wgde	694	77	reactive	reactive	JJ
cord-336510-qzm9wgde	694	78	oxygen	oxygen	NN
cord-336510-qzm9wgde	694	79	species	specie	NNS
cord-336510-qzm9wgde	694	80	and	and	CC
cord-336510-qzm9wgde	694	81	cell	cell	NN
cord-336510-qzm9wgde	694	82	cycle	cycle	NN
cord-336510-qzm9wgde	694	83	progression	progression	NN
cord-336510-qzm9wgde	694	84	in	in	IN
cord-336510-qzm9wgde	694	85	mammalian	mammalian	JJ
cord-336510-qzm9wgde	694	86	cells	cell	NNS
cord-336510-qzm9wgde	694	87	Herpes	Herpes	NNP
cord-336510-qzm9wgde	694	88	simplex	simplex	NN
cord-336510-qzm9wgde	694	89	virus	virus	NN
cord-336510-qzm9wgde	694	90	type	type	NN
cord-336510-qzm9wgde	694	91	2	2	CD
cord-336510-qzm9wgde	694	92	primes	prime	VBZ
cord-336510-qzm9wgde	694	93	mouse	mouse	NN
cord-336510-qzm9wgde	694	94	macrophages	macrophage	NNS
cord-336510-qzm9wgde	694	95	for	for	IN
cord-336510-qzm9wgde	694	96	an	an	DT
cord-336510-qzm9wgde	694	97	early	early	JJ
cord-336510-qzm9wgde	694	98	and	and	CC
cord-336510-qzm9wgde	694	99	genetically	genetically	RB
cord-336510-qzm9wgde	694	100	determined	determined	JJ
cord-336510-qzm9wgde	694	101	respiratory	respiratory	JJ
cord-336510-qzm9wgde	694	102	burst	burst	NN
cord-336510-qzm9wgde	694	103	mediated	mediate	VBN
cord-336510-qzm9wgde	694	104	by	by	IN
cord-336510-qzm9wgde	694	105	interferon	interferon	NN
cord-336510-qzm9wgde	694	106	-	-	HYPH
cord-336510-qzm9wgde	694	107	alpha	alpha	NN
cord-336510-qzm9wgde	694	108	/	/	SYM
cord-336510-qzm9wgde	694	109	beta	beta	NN
cord-336510-qzm9wgde	694	110	A	a	DT
cord-336510-qzm9wgde	694	111	proinflammatory	proinflammatory	JJ
cord-336510-qzm9wgde	694	112	peptide	peptide	NN
cord-336510-qzm9wgde	694	113	from	from	IN
cord-336510-qzm9wgde	694	114	herpes	herpes	NNP
cord-336510-qzm9wgde	694	115	simplex	simplex	NNP
cord-336510-qzm9wgde	694	116	virus	virus	NN
cord-336510-qzm9wgde	694	117	type	type	NN
cord-336510-qzm9wgde	694	118	2	2	CD
cord-336510-qzm9wgde	694	119	glycoprotein	glycoprotein	NN
cord-336510-qzm9wgde	694	120	G	g	NN
cord-336510-qzm9wgde	694	121	affects	affect	VBZ
cord-336510-qzm9wgde	694	122	neutrophil	neutrophil	NN
cord-336510-qzm9wgde	694	123	,	,	,
cord-336510-qzm9wgde	694	124	monocyte	monocyte	NNP
cord-336510-qzm9wgde	694	125	,	,	,
cord-336510-qzm9wgde	694	126	and	and	CC
cord-336510-qzm9wgde	694	127	NK	NK	NNP
cord-336510-qzm9wgde	694	128	cell	cell	NN
cord-336510-qzm9wgde	694	129	functions	function	NNS
cord-336510-qzm9wgde	694	130	Strain	strain	VB
cord-336510-qzm9wgde	694	131	dependence	dependence	NN
cord-336510-qzm9wgde	694	132	of	of	IN
cord-336510-qzm9wgde	694	133	the	the	DT
cord-336510-qzm9wgde	694	134	antiproliferative	antiproliferative	JJ
cord-336510-qzm9wgde	694	135	action	action	NN
cord-336510-qzm9wgde	694	136	of	of	IN
cord-336510-qzm9wgde	694	137	interferon	interferon	NN
cord-336510-qzm9wgde	694	138	on	on	IN
cord-336510-qzm9wgde	694	139	murine	murine	JJ
cord-336510-qzm9wgde	694	140	erythroid	erythroid	JJ
cord-336510-qzm9wgde	694	141	precursors	precursor	NNS
cord-336510-qzm9wgde	694	142	Herpes	Herpes	NNP
cord-336510-qzm9wgde	694	143	simplex	simplex	NN
cord-336510-qzm9wgde	694	144	virus	virus	NN
cord-336510-qzm9wgde	694	145	type	type	NN
cord-336510-qzm9wgde	694	146	1	1	CD
cord-336510-qzm9wgde	694	147	latency	latency	NN
cord-336510-qzm9wgde	694	148	in	in	IN
cord-336510-qzm9wgde	694	149	the	the	DT
cord-336510-qzm9wgde	694	150	murine	murine	JJ
cord-336510-qzm9wgde	694	151	nervous	nervous	JJ
cord-336510-qzm9wgde	694	152	system	system	NN
cord-336510-qzm9wgde	694	153	is	be	VBZ
cord-336510-qzm9wgde	694	154	associated	associate	VBN
cord-336510-qzm9wgde	694	155	with	with	IN
cord-336510-qzm9wgde	694	156	oxidative	oxidative	JJ
cord-336510-qzm9wgde	694	157	damage	damage	NN
cord-336510-qzm9wgde	694	158	to	to	IN
cord-336510-qzm9wgde	694	159	neurons	neuron	NNS
cord-336510-qzm9wgde	695	1	The	the	DT
cord-336510-qzm9wgde	695	2	antiviral	antiviral	JJ
cord-336510-qzm9wgde	695	3	activity	activity	NN
cord-336510-qzm9wgde	695	4	of	of	IN
cord-336510-qzm9wgde	695	5	tumour	tumour	NN
cord-336510-qzm9wgde	695	6	necrosis	necrosis	NN
cord-336510-qzm9wgde	695	7	factor	factor	NN
cord-336510-qzm9wgde	695	8	on	on	IN
cord-336510-qzm9wgde	695	9	herpes	herpes	NNP
cord-336510-qzm9wgde	695	10	simplex	simplex	NNP
cord-336510-qzm9wgde	695	11	virus	virus	NN
cord-336510-qzm9wgde	695	12	type	type	NN
cord-336510-qzm9wgde	695	13	1	1	CD
cord-336510-qzm9wgde	695	14	:	:	:
cord-336510-qzm9wgde	695	15	role	role	NN
cord-336510-qzm9wgde	695	16	for	for	IN
cord-336510-qzm9wgde	695	17	a	a	DT
cord-336510-qzm9wgde	695	18	butylated	butylate	VBN
cord-336510-qzm9wgde	695	19	hydroxyanisole	hydroxyanisole	NNP
cord-336510-qzm9wgde	695	20	sensitive	sensitive	JJ
cord-336510-qzm9wgde	695	21	factor	factor	NN
cord-336510-qzm9wgde	695	22	Herpes	Herpes	NNP
cord-336510-qzm9wgde	695	23	simplex	simplex	NN
cord-336510-qzm9wgde	695	24	virus	virus	NN
cord-336510-qzm9wgde	696	1	1	1	CD
cord-336510-qzm9wgde	696	2	induces	induce	VBZ
cord-336510-qzm9wgde	696	3	and	and	CC
cord-336510-qzm9wgde	696	4	blocks	block	VBZ
cord-336510-qzm9wgde	696	5	apoptosis	apoptosis	NN
cord-336510-qzm9wgde	696	6	at	at	IN
cord-336510-qzm9wgde	696	7	multiple	multiple	JJ
cord-336510-qzm9wgde	696	8	steps	step	NNS
cord-336510-qzm9wgde	696	9	during	during	IN
cord-336510-qzm9wgde	696	10	infection	infection	NN
cord-336510-qzm9wgde	696	11	and	and	CC
cord-336510-qzm9wgde	696	12	protects	protect	VBZ
cord-336510-qzm9wgde	696	13	cells	cell	NNS
cord-336510-qzm9wgde	696	14	from	from	IN
cord-336510-qzm9wgde	696	15	exogenous	exogenous	JJ
cord-336510-qzm9wgde	696	16	inducers	inducer	NNS
cord-336510-qzm9wgde	696	17	in	in	IN
cord-336510-qzm9wgde	696	18	a	a	DT
cord-336510-qzm9wgde	696	19	cell	cell	NN
cord-336510-qzm9wgde	696	20	-	-	HYPH
cord-336510-qzm9wgde	696	21	type	type	NN
cord-336510-qzm9wgde	696	22	-	-	HYPH
cord-336510-qzm9wgde	696	23	dependent	dependent	JJ
cord-336510-qzm9wgde	696	24	manner	manner	NN
cord-336510-qzm9wgde	696	25	A	a	DT
cord-336510-qzm9wgde	696	26	role	role	NN
cord-336510-qzm9wgde	696	27	for	for	IN
cord-336510-qzm9wgde	696	28	apoptosis	apoptosis	NN
cord-336510-qzm9wgde	696	29	induced	induce	VBN
cord-336510-qzm9wgde	696	30	by	by	IN
cord-336510-qzm9wgde	696	31	acute	acute	JJ
cord-336510-qzm9wgde	696	32	herpes	herpes	NN
cord-336510-qzm9wgde	696	33	simplex	simplex	NN
cord-336510-qzm9wgde	696	34	virus	virus	NN
cord-336510-qzm9wgde	696	35	infection	infection	NN
cord-336510-qzm9wgde	696	36	in	in	IN
cord-336510-qzm9wgde	696	37	mice	mouse	NNS
cord-336510-qzm9wgde	697	1	The	the	DT
cord-336510-qzm9wgde	697	2	role	role	NN
cord-336510-qzm9wgde	697	3	of	of	IN
cord-336510-qzm9wgde	697	4	natural	natural	JJ
cord-336510-qzm9wgde	697	5	killer	killer	NN
cord-336510-qzm9wgde	697	6	cells	cell	NNS
cord-336510-qzm9wgde	697	7	and	and	CC
cord-336510-qzm9wgde	697	8	interferon	interferon	NN
cord-336510-qzm9wgde	697	9	in	in	IN
cord-336510-qzm9wgde	697	10	resistance	resistance	NN
cord-336510-qzm9wgde	697	11	to	to	IN
cord-336510-qzm9wgde	697	12	acute	acute	JJ
cord-336510-qzm9wgde	697	13	infection	infection	NN
cord-336510-qzm9wgde	697	14	of	of	IN
cord-336510-qzm9wgde	697	15	mice	mouse	NNS
cord-336510-qzm9wgde	697	16	with	with	IN
cord-336510-qzm9wgde	697	17	herpes	herpes	NNP
cord-336510-qzm9wgde	697	18	simplex	simplex	NNP
cord-336510-qzm9wgde	697	19	virus	virus	NN
cord-336510-qzm9wgde	697	20	type	type	NN
cord-336510-qzm9wgde	697	21	1	1	CD
cord-336510-qzm9wgde	697	22	Treatment	treatment	NN
cord-336510-qzm9wgde	697	23	of	of	IN
cord-336510-qzm9wgde	697	24	neonatal	neonatal	JJ
cord-336510-qzm9wgde	697	25	mice	mouse	NNS
cord-336510-qzm9wgde	697	26	with	with	IN
cord-336510-qzm9wgde	697	27	Flt3	flt3	NN
cord-336510-qzm9wgde	697	28	ligand	ligand	NN
cord-336510-qzm9wgde	697	29	leads	lead	VBZ
cord-336510-qzm9wgde	697	30	to	to	IN
cord-336510-qzm9wgde	697	31	changes	change	NNS
cord-336510-qzm9wgde	697	32	in	in	IN
cord-336510-qzm9wgde	697	33	dendritic	dendritic	JJ
cord-336510-qzm9wgde	697	34	cell	cell	NN
cord-336510-qzm9wgde	697	35	subpopulations	subpopulation	NNS
cord-336510-qzm9wgde	697	36	associated	associate	VBN
cord-336510-qzm9wgde	697	37	with	with	IN
cord-336510-qzm9wgde	697	38	enhanced	enhanced	JJ
cord-336510-qzm9wgde	697	39	IL-12	IL-12	NNP
cord-336510-qzm9wgde	697	40	and	and	CC
cord-336510-qzm9wgde	697	41	IFN	IFN	NNP
cord-336510-qzm9wgde	697	42	-	-	HYPH
cord-336510-qzm9wgde	697	43	alpha	alpha	NN
cord-336510-qzm9wgde	697	44	production	production	NN
cord-336510-qzm9wgde	697	45	Flt3	Flt3	NNP
cord-336510-qzm9wgde	697	46	ligandtreated	ligandtreate	VBD
cord-336510-qzm9wgde	697	47	neonatal	neonatal	JJ
cord-336510-qzm9wgde	697	48	mice	mouse	NNS
cord-336510-qzm9wgde	697	49	have	have	VBP
cord-336510-qzm9wgde	697	50	increased	increase	VBN
cord-336510-qzm9wgde	697	51	innate	innate	JJ
cord-336510-qzm9wgde	697	52	immunity	immunity	NN
cord-336510-qzm9wgde	697	53	against	against	IN
cord-336510-qzm9wgde	697	54	intracellular	intracellular	JJ
cord-336510-qzm9wgde	697	55	pathogens	pathogen	NNS
cord-336510-qzm9wgde	697	56	and	and	CC
cord-336510-qzm9wgde	697	57	efficiently	efficiently	RB
cord-336510-qzm9wgde	697	58	control	control	VBP
cord-336510-qzm9wgde	697	59	virus	virus	NN
cord-336510-qzm9wgde	697	60	infections	infection	NNS
cord-336510-qzm9wgde	697	61	Interplay	interplay	VBP
cord-336510-qzm9wgde	697	62	between	between	IN
cord-336510-qzm9wgde	697	63	alpha	alpha	NN
cord-336510-qzm9wgde	697	64	/	/	SYM
cord-336510-qzm9wgde	697	65	beta	beta	NN
cord-336510-qzm9wgde	697	66	and	and	CC
cord-336510-qzm9wgde	697	67	gamma	gamma	NN
cord-336510-qzm9wgde	697	68	interferons	interferon	NNS
cord-336510-qzm9wgde	697	69	with	with	IN
cord-336510-qzm9wgde	697	70	B	B	NNP
cord-336510-qzm9wgde	697	71	,	,	,
cord-336510-qzm9wgde	697	72	T	T	NNP
cord-336510-qzm9wgde	697	73	,	,	,
cord-336510-qzm9wgde	697	74	and	and	CC
cord-336510-qzm9wgde	697	75	natural	natural	JJ
cord-336510-qzm9wgde	697	76	killer	killer	NN
cord-336510-qzm9wgde	697	77	cells	cell	NNS
cord-336510-qzm9wgde	697	78	in	in	IN
cord-336510-qzm9wgde	697	79	the	the	DT
cord-336510-qzm9wgde	697	80	defense	defense	NN
cord-336510-qzm9wgde	697	81	against	against	IN
cord-336510-qzm9wgde	697	82	herpes	herpes	NNP
cord-336510-qzm9wgde	697	83	simplex	simplex	NNP
cord-336510-qzm9wgde	697	84	virus	virus	NN
cord-336510-qzm9wgde	697	85	type	type	NN
cord-336510-qzm9wgde	697	86	1	1	CD
cord-336510-qzm9wgde	697	87	Type	type	NN
cord-336510-qzm9wgde	697	88	I	-PRON-	PRP
cord-336510-qzm9wgde	697	89	interferons	interferon	NNS
cord-336510-qzm9wgde	697	90	and	and	CC
cord-336510-qzm9wgde	697	91	herpes	herpes	NN
cord-336510-qzm9wgde	697	92	simplex	simplex	NNP
cord-336510-qzm9wgde	697	93	virus	virus	NN
cord-336510-qzm9wgde	697	94	infection	infection	NN
cord-336510-qzm9wgde	697	95	:	:	:
cord-336510-qzm9wgde	697	96	a	a	DT
cord-336510-qzm9wgde	697	97	naked	naked	JJ
cord-336510-qzm9wgde	697	98	DNA	dna	NN
cord-336510-qzm9wgde	697	99	approach	approach	NN
cord-336510-qzm9wgde	697	100	as	as	IN
cord-336510-qzm9wgde	697	101	a	a	DT
cord-336510-qzm9wgde	697	102	therapeutic	therapeutic	JJ
cord-336510-qzm9wgde	697	103	option	option	NN
cord-336510-qzm9wgde	697	104	Herpes	Herpes	NNP
cord-336510-qzm9wgde	697	105	simplex	simplex	NN
cord-336510-qzm9wgde	697	106	virus	virus	NN
cord-336510-qzm9wgde	697	107	type	type	NN
cord-336510-qzm9wgde	697	108	1-mediated	1-mediated	CD
cord-336510-qzm9wgde	697	109	up	up	IN
cord-336510-qzm9wgde	697	110	-	-	HYPH
cord-336510-qzm9wgde	697	111	regulation	regulation	NN
cord-336510-qzm9wgde	697	112	of	of	IN
cord-336510-qzm9wgde	697	113	IL-12	IL-12	NNP
cord-336510-qzm9wgde	697	114	(	(	-LRB-
cord-336510-qzm9wgde	697	115	p40	p40	NN
cord-336510-qzm9wgde	697	116	)	)	-RRB-
cord-336510-qzm9wgde	697	117	mRNA	mrna	NN
cord-336510-qzm9wgde	697	118	expression	expression	NN
cord-336510-qzm9wgde	697	119	.	.	.
cord-336510-qzm9wgde	698	1	Implications	implication	NNS
cord-336510-qzm9wgde	698	2	in	in	IN
cord-336510-qzm9wgde	698	3	immunopathogenesis	immunopathogenesis	NN
cord-336510-qzm9wgde	698	4	and	and	CC
cord-336510-qzm9wgde	698	5	protection	protection	NN
cord-336510-qzm9wgde	698	6	Interleukin-12	interleukin-12	XX
cord-336510-qzm9wgde	698	7	gene	gene	NN
cord-336510-qzm9wgde	698	8	expression	expression	NN
cord-336510-qzm9wgde	698	9	after	after	IN
cord-336510-qzm9wgde	698	10	viral	viral	JJ
cord-336510-qzm9wgde	698	11	infection	infection	NN
cord-336510-qzm9wgde	698	12	in	in	IN
cord-336510-qzm9wgde	698	13	the	the	DT
cord-336510-qzm9wgde	698	14	mouse	mouse	NN
cord-336510-qzm9wgde	698	15	The	the	DT
cord-336510-qzm9wgde	698	16	IL-12	IL-12	NNP
cord-336510-qzm9wgde	698	17	response	response	NN
cord-336510-qzm9wgde	698	18	to	to	IN
cord-336510-qzm9wgde	698	19	herpes	herpes	NNP
cord-336510-qzm9wgde	698	20	simplex	simplex	NNP
cord-336510-qzm9wgde	698	21	virus	virus	NN
cord-336510-qzm9wgde	698	22	is	be	VBZ
cord-336510-qzm9wgde	698	23	mainly	mainly	RB
cord-336510-qzm9wgde	698	24	a	a	DT
cord-336510-qzm9wgde	698	25	paracrine	paracrine	JJ
cord-336510-qzm9wgde	698	26	response	response	NN
cord-336510-qzm9wgde	698	27	of	of	IN
cord-336510-qzm9wgde	698	28	reactive	reactive	JJ
cord-336510-qzm9wgde	698	29	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	698	30	cells	cell	NNS
cord-336510-qzm9wgde	698	31	Inhibition	inhibition	NN
cord-336510-qzm9wgde	698	32	of	of	IN
cord-336510-qzm9wgde	698	33	IL-12	IL-12	NNP
cord-336510-qzm9wgde	698	34	production	production	NN
cord-336510-qzm9wgde	698	35	in	in	IN
cord-336510-qzm9wgde	698	36	human	human	JJ
cord-336510-qzm9wgde	698	37	monocyte	monocyte	NN
cord-336510-qzm9wgde	698	38	-	-	HYPH
cord-336510-qzm9wgde	698	39	derived	derive	VBN
cord-336510-qzm9wgde	698	40	macrophages	macrophage	NNS
cord-336510-qzm9wgde	698	41	by	by	IN
cord-336510-qzm9wgde	698	42	TNF	TNF	NNP
cord-336510-qzm9wgde	698	43	Pure	Pure	NNP
cord-336510-qzm9wgde	698	44	E	E	NNP
cord-336510-qzm9wgde	698	45	:	:	:
cord-336510-qzm9wgde	699	1	Inhibition	inhibition	NN
cord-336510-qzm9wgde	699	2	of	of	IN
cord-336510-qzm9wgde	699	3	interferon	interferon	NN
cord-336510-qzm9wgde	699	4	gamma	gamma	NN
cord-336510-qzm9wgde	699	5	induced	induce	VBN
cord-336510-qzm9wgde	699	6	interleukin	interleukin	NN
cord-336510-qzm9wgde	699	7	12	12	CD
cord-336510-qzm9wgde	699	8	production	production	NN
cord-336510-qzm9wgde	699	9	:	:	:
cord-336510-qzm9wgde	699	10	a	a	DT
cord-336510-qzm9wgde	699	11	potential	potential	JJ
cord-336510-qzm9wgde	699	12	mechanism	mechanism	NN
cord-336510-qzm9wgde	699	13	for	for	IN
cord-336510-qzm9wgde	699	14	the	the	DT
cord-336510-qzm9wgde	699	15	anti	anti	JJ
cord-336510-qzm9wgde	699	16	-	-	JJ
cord-336510-qzm9wgde	699	17	inflammatory	inflammatory	JJ
cord-336510-qzm9wgde	699	18	activities	activity	NNS
cord-336510-qzm9wgde	699	19	of	of	IN
cord-336510-qzm9wgde	699	20	tumor	tumor	NN
cord-336510-qzm9wgde	699	21	necrosis	necrosis	NN
cord-336510-qzm9wgde	699	22	factor	factor	NN
cord-336510-qzm9wgde	699	23	Interferon	interferon	NN
cord-336510-qzm9wgde	699	24	-	-	HYPH
cord-336510-qzm9wgde	699	25	alpha	alpha	NN
cord-336510-qzm9wgde	699	26	/	/	SYM
cord-336510-qzm9wgde	699	27	beta	beta	NN
cord-336510-qzm9wgde	699	28	inhibition	inhibition	NN
cord-336510-qzm9wgde	699	29	of	of	IN
cord-336510-qzm9wgde	699	30	interleukin	interleukin	NN
cord-336510-qzm9wgde	699	31	12	12	CD
cord-336510-qzm9wgde	699	32	and	and	CC
cord-336510-qzm9wgde	699	33	interferon	interferon	NN
cord-336510-qzm9wgde	699	34	-	-	HYPH
cord-336510-qzm9wgde	699	35	gamma	gamma	NN
cord-336510-qzm9wgde	699	36	production	production	NN
cord-336510-qzm9wgde	699	37	in	in	IN
cord-336510-qzm9wgde	699	38	vitro	vitro	FW
cord-336510-qzm9wgde	699	39	and	and	CC
cord-336510-qzm9wgde	699	40	endogenously	endogenously	RB
cord-336510-qzm9wgde	699	41	during	during	IN
cord-336510-qzm9wgde	699	42	viral	viral	JJ
cord-336510-qzm9wgde	699	43	infection	infection	NN
cord-336510-qzm9wgde	699	44	Type	type	NN
cord-336510-qzm9wgde	699	45	I	-PRON-	PRP
cord-336510-qzm9wgde	699	46	interferons	interferon	NNS
cord-336510-qzm9wgde	699	47	and	and	CC
cord-336510-qzm9wgde	699	48	IL-12	il-12	NN
cord-336510-qzm9wgde	699	49	:	:	:
cord-336510-qzm9wgde	699	50	convergence	convergence	NN
cord-336510-qzm9wgde	699	51	and	and	CC
cord-336510-qzm9wgde	699	52	cross	cross	NN
cord-336510-qzm9wgde	699	53	-	-	NN
cord-336510-qzm9wgde	699	54	regulation	regulation	NN
cord-336510-qzm9wgde	699	55	among	among	IN
cord-336510-qzm9wgde	699	56	mediators	mediator	NNS
cord-336510-qzm9wgde	699	57	of	of	IN
cord-336510-qzm9wgde	699	58	cellular	cellular	JJ
cord-336510-qzm9wgde	699	59	immunity	immunity	NN
cord-336510-qzm9wgde	700	1	Interferon	interferon	NN
cord-336510-qzm9wgde	700	2	alpha	alpha	NN
cord-336510-qzm9wgde	700	3	/	/	SYM
cord-336510-qzm9wgde	700	4	beta	beta	NN
cord-336510-qzm9wgde	700	5	and	and	CC
cord-336510-qzm9wgde	700	6	interleukin	interleukin	NN
cord-336510-qzm9wgde	700	7	12	12	CD
cord-336510-qzm9wgde	700	8	responses	response	NNS
cord-336510-qzm9wgde	700	9	to	to	IN
cord-336510-qzm9wgde	700	10	viral	viral	JJ
cord-336510-qzm9wgde	700	11	infections	infection	NNS
cord-336510-qzm9wgde	700	12	:	:	:
cord-336510-qzm9wgde	701	1	pathways	pathway	NNS
cord-336510-qzm9wgde	701	2	regulating	regulate	VBG
cord-336510-qzm9wgde	701	3	dendritic	dendritic	JJ
cord-336510-qzm9wgde	701	4	cell	cell	NN
cord-336510-qzm9wgde	701	5	cytokine	cytokine	NN
cord-336510-qzm9wgde	701	6	expression	expression	NN
cord-336510-qzm9wgde	701	7	in	in	IN
cord-336510-qzm9wgde	701	8	vivo	vivo	NN
cord-336510-qzm9wgde	701	9	IL-12	IL-12	NNP
cord-336510-qzm9wgde	701	10	is	be	VBZ
cord-336510-qzm9wgde	701	11	dysregulated	dysregulate	VBN
cord-336510-qzm9wgde	701	12	in	in	IN
cord-336510-qzm9wgde	701	13	macrophages	macrophage	NNS
cord-336510-qzm9wgde	701	14	from	from	IN
cord-336510-qzm9wgde	701	15	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	701	16	and	and	CC
cord-336510-qzm9wgde	701	17	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	702	1	knockout	knockout	NNP
cord-336510-qzm9wgde	702	2	mice	mouse	NNS
cord-336510-qzm9wgde	703	1	IRF-8	IRF-8	NNP
cord-336510-qzm9wgde	703	2	/	/	SYM
cord-336510-qzm9wgde	703	3	ICSBP	ICSBP	NNP
cord-336510-qzm9wgde	703	4	and	and	CC
cord-336510-qzm9wgde	703	5	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	703	6	cooperatively	cooperatively	RB
cord-336510-qzm9wgde	703	7	stimulate	stimulate	VBP
cord-336510-qzm9wgde	703	8	mouse	mouse	NN
cord-336510-qzm9wgde	703	9	IL-12	IL-12	NNP
cord-336510-qzm9wgde	703	10	promoter	promoter	NN
cord-336510-qzm9wgde	703	11	activity	activity	NN
cord-336510-qzm9wgde	703	12	in	in	IN
cord-336510-qzm9wgde	703	13	macrophages	macrophage	NNS
cord-336510-qzm9wgde	704	1	In	in	IN
cord-336510-qzm9wgde	704	2	vitro	vitro	FW
cord-336510-qzm9wgde	704	3	production	production	NN
cord-336510-qzm9wgde	704	4	of	of	IN
cord-336510-qzm9wgde	704	5	immune	immune	JJ
cord-336510-qzm9wgde	704	6	interferon	interferon	NN
cord-336510-qzm9wgde	704	7	by	by	IN
cord-336510-qzm9wgde	704	8	spleen	spleen	NN
cord-336510-qzm9wgde	704	9	cells	cell	NNS
cord-336510-qzm9wgde	704	10	of	of	IN
cord-336510-qzm9wgde	704	11	mice	mouse	NNS
cord-336510-qzm9wgde	704	12	immunized	immunize	VBN
cord-336510-qzm9wgde	704	13	with	with	IN
cord-336510-qzm9wgde	704	14	herpes	herpes	NNP
cord-336510-qzm9wgde	704	15	simplex	simplex	NNP
cord-336510-qzm9wgde	704	16	virus	virus	NN
cord-336510-qzm9wgde	704	17	Type	type	NN
cord-336510-qzm9wgde	705	1	I	-PRON-	PRP
cord-336510-qzm9wgde	705	2	interferons	interferon	NNS
cord-336510-qzm9wgde	705	3	enhance	enhance	VBP
cord-336510-qzm9wgde	705	4	production	production	NN
cord-336510-qzm9wgde	705	5	of	of	IN
cord-336510-qzm9wgde	705	6	IFN	IFN	NNP
cord-336510-qzm9wgde	705	7	-	-	HYPH
cord-336510-qzm9wgde	705	8	gamma	gamma	NN
cord-336510-qzm9wgde	705	9	by	by	IN
cord-336510-qzm9wgde	705	10	NK	NK	NNP
cord-336510-qzm9wgde	705	11	cells	cell	NNS
cord-336510-qzm9wgde	706	1	Interferon	Interferon	NNP
cord-336510-qzm9wgde	706	2	(	(	-LRB-
cord-336510-qzm9wgde	706	3	IFN)-alpha	ifn)-alpha	$
cord-336510-qzm9wgde	706	4	/	/	SYM
cord-336510-qzm9wgde	706	5	beta	beta	NN
cord-336510-qzm9wgde	706	6	,	,	,
cord-336510-qzm9wgde	706	7	interleukin	interleukin	FW
cord-336510-qzm9wgde	706	8	(	(	-LRB-
cord-336510-qzm9wgde	706	9	IL)-12	il)-12	NN
cord-336510-qzm9wgde	706	10	and	and	CC
cord-336510-qzm9wgde	706	11	IL-18	IL-18	NNP
cord-336510-qzm9wgde	706	12	coordinately	coordinately	RB
cord-336510-qzm9wgde	706	13	induce	induce	VBP
cord-336510-qzm9wgde	706	14	production	production	NN
cord-336510-qzm9wgde	706	15	of	of	IN
cord-336510-qzm9wgde	706	16	IFN	IFN	NNP
cord-336510-qzm9wgde	706	17	-	-	HYPH
cord-336510-qzm9wgde	706	18	gamma	gamma	NN
cord-336510-qzm9wgde	706	19	during	during	IN
cord-336510-qzm9wgde	706	20	infection	infection	NN
cord-336510-qzm9wgde	706	21	with	with	IN
cord-336510-qzm9wgde	706	22	herpes	herpes	NNP
cord-336510-qzm9wgde	706	23	simplex	simplex	NNP
cord-336510-qzm9wgde	706	24	virus	virus	NN
cord-336510-qzm9wgde	706	25	type	type	NN
cord-336510-qzm9wgde	706	26	Differential	differential	JJ
cord-336510-qzm9wgde	706	27	secretion	secretion	NN
cord-336510-qzm9wgde	706	28	of	of	IN
cord-336510-qzm9wgde	706	29	TNF	tnf	NN
cord-336510-qzm9wgde	706	30	-	-	HYPH
cord-336510-qzm9wgde	706	31	alpha	alpha	NN
cord-336510-qzm9wgde	706	32	and	and	CC
cord-336510-qzm9wgde	706	33	IFN	IFN	NNP
cord-336510-qzm9wgde	706	34	-	-	HYPH
cord-336510-qzm9wgde	706	35	gamma	gamma	NN
cord-336510-qzm9wgde	706	36	by	by	IN
cord-336510-qzm9wgde	706	37	human	human	JJ
cord-336510-qzm9wgde	706	38	peripheral	peripheral	JJ
cord-336510-qzm9wgde	706	39	bloodderived	bloodderived	JJ
cord-336510-qzm9wgde	706	40	NK	NK	NNP
cord-336510-qzm9wgde	706	41	subsets	subset	NNS
cord-336510-qzm9wgde	706	42	and	and	CC
cord-336510-qzm9wgde	706	43	association	association	NN
cord-336510-qzm9wgde	706	44	with	with	IN
cord-336510-qzm9wgde	706	45	functional	functional	JJ
cord-336510-qzm9wgde	706	46	maturation	maturation	NN
cord-336510-qzm9wgde	707	1	The	the	DT
cord-336510-qzm9wgde	707	2	role	role	NN
cord-336510-qzm9wgde	707	3	of	of	IN
cord-336510-qzm9wgde	707	4	Stat4	Stat4	NNS
cord-336510-qzm9wgde	707	5	in	in	IN
cord-336510-qzm9wgde	707	6	species	species	NN
cord-336510-qzm9wgde	707	7	-	-	HYPH
cord-336510-qzm9wgde	707	8	specific	specific	JJ
cord-336510-qzm9wgde	707	9	regulation	regulation	NN
cord-336510-qzm9wgde	707	10	of	of	IN
cord-336510-qzm9wgde	707	11	Th	Th	NNP
cord-336510-qzm9wgde	707	12	cell	cell	NN
cord-336510-qzm9wgde	707	13	development	development	NN
cord-336510-qzm9wgde	707	14	by	by	IN
cord-336510-qzm9wgde	707	15	type	type	NN
cord-336510-qzm9wgde	708	1	I	-PRON-	PRP
cord-336510-qzm9wgde	708	2	IFNs	ifns	VBP
cord-336510-qzm9wgde	708	3	Interleukin	Interleukin	NNP
cord-336510-qzm9wgde	708	4	12	12	CD
cord-336510-qzm9wgde	708	5	and	and	CC
cord-336510-qzm9wgde	708	6	tumor	tumor	NN
cord-336510-qzm9wgde	708	7	necrosis	necrosis	NN
cord-336510-qzm9wgde	708	8	factor	factor	NN
cord-336510-qzm9wgde	709	1	alpha	alpha	NN
cord-336510-qzm9wgde	709	2	are	be	VBP
cord-336510-qzm9wgde	709	3	costimulators	costimulator	NNS
cord-336510-qzm9wgde	709	4	of	of	IN
cord-336510-qzm9wgde	709	5	interferon	interferon	NN
cord-336510-qzm9wgde	709	6	gamma	gamma	NN
cord-336510-qzm9wgde	709	7	production	production	NN
cord-336510-qzm9wgde	709	8	by	by	IN
cord-336510-qzm9wgde	709	9	natural	natural	JJ
cord-336510-qzm9wgde	709	10	killer	killer	NN
cord-336510-qzm9wgde	709	11	cells	cell	NNS
cord-336510-qzm9wgde	709	12	in	in	IN
cord-336510-qzm9wgde	709	13	severe	severe	JJ
cord-336510-qzm9wgde	709	14	combined	combine	VBN
cord-336510-qzm9wgde	709	15	immunodeficiency	immunodeficiency	NN
cord-336510-qzm9wgde	709	16	mice	mouse	NNS
cord-336510-qzm9wgde	709	17	with	with	IN
cord-336510-qzm9wgde	709	18	listeriosis	listeriosis	NN
cord-336510-qzm9wgde	709	19	,	,	,
cord-336510-qzm9wgde	709	20	and	and	CC
cord-336510-qzm9wgde	709	21	interleukin	interleukin	NN
cord-336510-qzm9wgde	709	22	10	10	CD
cord-336510-qzm9wgde	709	23	is	be	VBZ
cord-336510-qzm9wgde	709	24	a	a	DT
cord-336510-qzm9wgde	709	25	physiologic	physiologic	JJ
cord-336510-qzm9wgde	709	26	antagonist	antagonist	NN
cord-336510-qzm9wgde	709	27	IL-1	IL-1	NNP
cord-336510-qzm9wgde	709	28	alpha	alpha	NN
cord-336510-qzm9wgde	709	29	and	and	CC
cord-336510-qzm9wgde	709	30	TNF	TNF	NNP
cord-336510-qzm9wgde	709	31	-	-	HYPH
cord-336510-qzm9wgde	709	32	alpha	alpha	NN
cord-336510-qzm9wgde	709	33	are	be	VBP
cord-336510-qzm9wgde	709	34	required	require	VBN
cord-336510-qzm9wgde	709	35	for	for	IN
cord-336510-qzm9wgde	709	36	IL-12-induced	il-12-induced	JJ
cord-336510-qzm9wgde	709	37	development	development	NN
cord-336510-qzm9wgde	709	38	of	of	IN
cord-336510-qzm9wgde	709	39	Th1	th1	NN
cord-336510-qzm9wgde	709	40	cells	cell	NNS
cord-336510-qzm9wgde	709	41	producing	produce	VBG
cord-336510-qzm9wgde	709	42	high	high	JJ
cord-336510-qzm9wgde	709	43	levels	level	NNS
cord-336510-qzm9wgde	709	44	of	of	IN
cord-336510-qzm9wgde	709	45	IFN	IFN	NNP
cord-336510-qzm9wgde	709	46	-	-	HYPH
cord-336510-qzm9wgde	709	47	gamma	gamma	NN
cord-336510-qzm9wgde	709	48	in	in	IN
cord-336510-qzm9wgde	709	49	BALB	BALB	NNP
cord-336510-qzm9wgde	709	50	/	/	SYM
cord-336510-qzm9wgde	709	51	c	c	NN
cord-336510-qzm9wgde	709	52	but	but	CC
cord-336510-qzm9wgde	709	53	not	not	RB
cord-336510-qzm9wgde	709	54	C57BL/	c57bl/	XX
cord-336510-qzm9wgde	710	1	6	6	CD
cord-336510-qzm9wgde	710	2	mice	mouse	NNS
cord-336510-qzm9wgde	711	1	Inhibition	inhibition	NN
cord-336510-qzm9wgde	711	2	of	of	IN
cord-336510-qzm9wgde	711	3	replication	replication	NN
cord-336510-qzm9wgde	711	4	of	of	IN
cord-336510-qzm9wgde	711	5	herpes	herpes	NN
cord-336510-qzm9wgde	711	6	simplex	simplex	NNP
cord-336510-qzm9wgde	711	7	virus	virus	NN
cord-336510-qzm9wgde	711	8	in	in	IN
cord-336510-qzm9wgde	711	9	mouse	mouse	NN
cord-336510-qzm9wgde	711	10	macrophages	macrophage	NNS
cord-336510-qzm9wgde	711	11	by	by	IN
cord-336510-qzm9wgde	711	12	interferon	interferon	NN
cord-336510-qzm9wgde	711	13	Alpha	alpha	NN
cord-336510-qzm9wgde	711	14	/	/	,
cord-336510-qzm9wgde	711	15	Beta	beta	NN
cord-336510-qzm9wgde	712	1	interferon	interferon	NN
cord-336510-qzm9wgde	712	2	and	and	CC
cord-336510-qzm9wgde	712	3	gamma	gamma	NN
cord-336510-qzm9wgde	712	4	interferon	interferon	NN
cord-336510-qzm9wgde	712	5	synergize	synergize	VB
cord-336510-qzm9wgde	712	6	to	to	TO
cord-336510-qzm9wgde	712	7	inhibit	inhibit	VB
cord-336510-qzm9wgde	712	8	the	the	DT
cord-336510-qzm9wgde	712	9	replication	replication	NN
cord-336510-qzm9wgde	712	10	of	of	IN
cord-336510-qzm9wgde	712	11	herpes	herpes	NNP
cord-336510-qzm9wgde	712	12	simplex	simplex	NNP
cord-336510-qzm9wgde	712	13	virus	virus	NN
cord-336510-qzm9wgde	712	14	type	type	NN
cord-336510-qzm9wgde	713	1	1	1	LS
cord-336510-qzm9wgde	713	2	Mathematical	Mathematical	NNP
cord-336510-qzm9wgde	713	3	analysis	analysis	NN
cord-336510-qzm9wgde	713	4	demonstrates	demonstrate	VBZ
cord-336510-qzm9wgde	713	5	that	that	IN
cord-336510-qzm9wgde	713	6	interferons	interferon	NNS
cord-336510-qzm9wgde	713	7	-	-	:
cord-336510-qzm9wgde	713	8	beta	beta	NN
cord-336510-qzm9wgde	713	9	and	and	CC
cord-336510-qzm9wgde	713	10	-gamma	-gamma	WP
cord-336510-qzm9wgde	713	11	interact	interact	VB
cord-336510-qzm9wgde	713	12	in	in	IN
cord-336510-qzm9wgde	713	13	a	a	DT
cord-336510-qzm9wgde	713	14	multiplicative	multiplicative	JJ
cord-336510-qzm9wgde	713	15	manner	manner	NN
cord-336510-qzm9wgde	713	16	to	to	TO
cord-336510-qzm9wgde	713	17	disrupt	disrupt	VB
cord-336510-qzm9wgde	713	18	herpes	herpes	NN
cord-336510-qzm9wgde	713	19	simplex	simplex	NN
cord-336510-qzm9wgde	713	20	virus	virus	NN
cord-336510-qzm9wgde	713	21	replication	replication	NN
cord-336510-qzm9wgde	713	22	Effect	effect	NN
cord-336510-qzm9wgde	713	23	of	of	IN
cord-336510-qzm9wgde	713	24	interferon	interferon	NN
cord-336510-qzm9wgde	713	25	on	on	IN
cord-336510-qzm9wgde	713	26	replication	replication	NN
cord-336510-qzm9wgde	713	27	of	of	IN
cord-336510-qzm9wgde	713	28	herpes	herpes	NNP
cord-336510-qzm9wgde	713	29	simplex	simplex	NNP
cord-336510-qzm9wgde	713	30	virus	virus	NN
cord-336510-qzm9wgde	713	31	types	type	NNS
cord-336510-qzm9wgde	713	32	1	1	CD
cord-336510-qzm9wgde	713	33	and	and	CC
cord-336510-qzm9wgde	713	34	2	2	CD
cord-336510-qzm9wgde	713	35	in	in	IN
cord-336510-qzm9wgde	713	36	human	human	JJ
cord-336510-qzm9wgde	713	37	macrophages	macrophage	NNS
cord-336510-qzm9wgde	713	38	Mechanism	Mechanism	NNP
cord-336510-qzm9wgde	713	39	of	of	IN
cord-336510-qzm9wgde	713	40	inhibition	inhibition	NN
cord-336510-qzm9wgde	713	41	of	of	IN
cord-336510-qzm9wgde	713	42	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	713	43	replication	replication	NN
cord-336510-qzm9wgde	713	44	by	by	IN
cord-336510-qzm9wgde	713	45	tumor	tumor	NN
cord-336510-qzm9wgde	713	46	necrosis	necrosis	NN
cord-336510-qzm9wgde	713	47	factor	factor	NN
cord-336510-qzm9wgde	713	48	and	and	CC
cord-336510-qzm9wgde	713	49	interferon	interferon	NN
cord-336510-qzm9wgde	713	50	gamma	gamma	NN
cord-336510-qzm9wgde	713	51	Synergistic	synergistic	JJ
cord-336510-qzm9wgde	713	52	anti	anti	JJ
cord-336510-qzm9wgde	713	53	-	-	JJ
cord-336510-qzm9wgde	713	54	HSV	hsv	JJ
cord-336510-qzm9wgde	713	55	effect	effect	NN
cord-336510-qzm9wgde	713	56	of	of	IN
cord-336510-qzm9wgde	713	57	tumor	tumor	NN
cord-336510-qzm9wgde	713	58	necrosis	necrosis	NN
cord-336510-qzm9wgde	713	59	factor	factor	NN
cord-336510-qzm9wgde	713	60	alpha	alpha	NN
cord-336510-qzm9wgde	713	61	and	and	CC
cord-336510-qzm9wgde	713	62	interferon	interferon	NN
cord-336510-qzm9wgde	713	63	gamma	gamma	NN
cord-336510-qzm9wgde	713	64	in	in	IN
cord-336510-qzm9wgde	713	65	human	human	JJ
cord-336510-qzm9wgde	713	66	corneal	corneal	JJ
cord-336510-qzm9wgde	713	67	fibroblasts	fibroblast	NNS
cord-336510-qzm9wgde	713	68	is	be	VBZ
cord-336510-qzm9wgde	713	69	associated	associate	VBN
cord-336510-qzm9wgde	713	70	with	with	IN
cord-336510-qzm9wgde	713	71	interferon	interferon	NN
cord-336510-qzm9wgde	713	72	beta	beta	NN
cord-336510-qzm9wgde	713	73	induction	induction	NN
cord-336510-qzm9wgde	713	74	Synergistic	synergistic	JJ
cord-336510-qzm9wgde	713	75	anti	anti	JJ
cord-336510-qzm9wgde	713	76	-	-	JJ
cord-336510-qzm9wgde	713	77	herpes	herpes	JJ
cord-336510-qzm9wgde	713	78	effect	effect	NN
cord-336510-qzm9wgde	713	79	of	of	IN
cord-336510-qzm9wgde	713	80	TNF	tnf	NN
cord-336510-qzm9wgde	713	81	-	-	HYPH
cord-336510-qzm9wgde	713	82	alpha	alpha	NN
cord-336510-qzm9wgde	713	83	and	and	CC
cord-336510-qzm9wgde	713	84	IFN	IFN	NNP
cord-336510-qzm9wgde	713	85	-	-	HYPH
cord-336510-qzm9wgde	713	86	gamma	gamma	NN
cord-336510-qzm9wgde	713	87	in	in	IN
cord-336510-qzm9wgde	713	88	human	human	JJ
cord-336510-qzm9wgde	713	89	corneal	corneal	JJ
cord-336510-qzm9wgde	713	90	epithelial	epithelial	JJ
cord-336510-qzm9wgde	713	91	cells	cell	NNS
cord-336510-qzm9wgde	713	92	compared	compare	VBN
cord-336510-qzm9wgde	713	93	with	with	IN
cord-336510-qzm9wgde	713	94	that	that	DT
cord-336510-qzm9wgde	713	95	in	in	IN
cord-336510-qzm9wgde	713	96	corneal	corneal	JJ
cord-336510-qzm9wgde	713	97	fibroblasts	fibroblast	NNS
cord-336510-qzm9wgde	714	1	Daubener	Daubener	NNP
cord-336510-qzm9wgde	714	2	W	W	NNP
cord-336510-qzm9wgde	714	3	:	:	:
cord-336510-qzm9wgde	714	4	Inhibition	inhibition	NN
cord-336510-qzm9wgde	714	5	of	of	IN
cord-336510-qzm9wgde	714	6	human	human	JJ
cord-336510-qzm9wgde	714	7	herpes	herpes	NN
cord-336510-qzm9wgde	714	8	simplex	simplex	NNP
cord-336510-qzm9wgde	714	9	virus	virus	NN
cord-336510-qzm9wgde	714	10	type	type	NN
cord-336510-qzm9wgde	714	11	2	2	CD
cord-336510-qzm9wgde	714	12	by	by	IN
cord-336510-qzm9wgde	714	13	interferon	interferon	NN
cord-336510-qzm9wgde	714	14	gamma	gamma	NN
cord-336510-qzm9wgde	714	15	and	and	CC
cord-336510-qzm9wgde	714	16	tumor	tumor	NN
cord-336510-qzm9wgde	714	17	necrosis	necrosis	NN
cord-336510-qzm9wgde	714	18	factor	factor	NN
cord-336510-qzm9wgde	715	1	alpha	alpha	NNP
cord-336510-qzm9wgde	715	2	is	be	VBZ
cord-336510-qzm9wgde	715	3	mediated	mediate	VBN
cord-336510-qzm9wgde	715	4	by	by	IN
cord-336510-qzm9wgde	715	5	indoleamine	indoleamine	NN
cord-336510-qzm9wgde	715	6	2,3-dioxygenase	2,3-dioxygenase	CD
cord-336510-qzm9wgde	715	7	Interleukin-12	interleukin-12	XX
cord-336510-qzm9wgde	715	8	(	(	-LRB-
cord-336510-qzm9wgde	715	9	IL-12	IL-12	NNP
cord-336510-qzm9wgde	715	10	)	)	-RRB-
cord-336510-qzm9wgde	715	11	and	and	CC
cord-336510-qzm9wgde	715	12	IL-18	IL-18	NNP
cord-336510-qzm9wgde	715	13	are	be	VBP
cord-336510-qzm9wgde	715	14	important	important	JJ
cord-336510-qzm9wgde	715	15	in	in	IN
cord-336510-qzm9wgde	715	16	innate	innate	JJ
cord-336510-qzm9wgde	715	17	defense	defense	NN
cord-336510-qzm9wgde	715	18	against	against	IN
cord-336510-qzm9wgde	715	19	genital	genital	JJ
cord-336510-qzm9wgde	715	20	herpes	herpes	NNP
cord-336510-qzm9wgde	715	21	simplex	simplex	NN
cord-336510-qzm9wgde	715	22	virus	virus	NN
cord-336510-qzm9wgde	715	23	type	type	NN
cord-336510-qzm9wgde	715	24	2	2	CD
cord-336510-qzm9wgde	715	25	infection	infection	NN
cord-336510-qzm9wgde	715	26	in	in	IN
cord-336510-qzm9wgde	715	27	mice	mouse	NNS
cord-336510-qzm9wgde	715	28	but	but	CC
cord-336510-qzm9wgde	715	29	are	be	VBP
cord-336510-qzm9wgde	715	30	not	not	RB
cord-336510-qzm9wgde	715	31	required	require	VBN
cord-336510-qzm9wgde	715	32	for	for	IN
cord-336510-qzm9wgde	715	33	the	the	DT
cord-336510-qzm9wgde	715	34	development	development	NN
cord-336510-qzm9wgde	715	35	of	of	IN
cord-336510-qzm9wgde	715	36	acquired	acquire	VBN
cord-336510-qzm9wgde	715	37	gamma	gamma	NNP
cord-336510-qzm9wgde	715	38	interferon	interferon	NN
cord-336510-qzm9wgde	715	39	-	-	HYPH
cord-336510-qzm9wgde	715	40	mediated	mediate	VBN
cord-336510-qzm9wgde	715	41	protective	protective	JJ
cord-336510-qzm9wgde	715	42	immunity	immunity	NN
cord-336510-qzm9wgde	715	43	Interleukin-12-and	interleukin-12-and	CD
cord-336510-qzm9wgde	715	44	gamma	gamma	NN
cord-336510-qzm9wgde	716	1	interferon	interferon	NN
cord-336510-qzm9wgde	716	2	-	-	HYPH
cord-336510-qzm9wgde	716	3	dependent	dependent	JJ
cord-336510-qzm9wgde	716	4	innate	innate	JJ
cord-336510-qzm9wgde	716	5	immunity	immunity	NN
cord-336510-qzm9wgde	716	6	are	be	VBP
cord-336510-qzm9wgde	716	7	essential	essential	JJ
cord-336510-qzm9wgde	716	8	and	and	CC
cord-336510-qzm9wgde	716	9	sufficient	sufficient	JJ
cord-336510-qzm9wgde	716	10	for	for	IN
cord-336510-qzm9wgde	716	11	long	long	JJ
cord-336510-qzm9wgde	716	12	-	-	HYPH
cord-336510-qzm9wgde	716	13	term	term	NN
cord-336510-qzm9wgde	716	14	survival	survival	NN
cord-336510-qzm9wgde	716	15	of	of	IN
cord-336510-qzm9wgde	716	16	passively	passively	RB
cord-336510-qzm9wgde	716	17	immunized	immunize	VBN
cord-336510-qzm9wgde	716	18	mice	mouse	NNS
cord-336510-qzm9wgde	716	19	infected	infect	VBN
cord-336510-qzm9wgde	716	20	with	with	IN
cord-336510-qzm9wgde	716	21	herpes	herpes	NNP
cord-336510-qzm9wgde	716	22	simplex	simplex	NNP
cord-336510-qzm9wgde	716	23	virus	virus	NN
cord-336510-qzm9wgde	716	24	type	type	NN
cord-336510-qzm9wgde	716	25	1	1	CD
cord-336510-qzm9wgde	716	26	IL-12	IL-12	NNP
cord-336510-qzm9wgde	716	27	and	and	CC
cord-336510-qzm9wgde	716	28	IL-18	IL-18	NNP
cord-336510-qzm9wgde	716	29	act	act	VBP
cord-336510-qzm9wgde	716	30	in	in	IN
cord-336510-qzm9wgde	716	31	synergy	synergy	NN
cord-336510-qzm9wgde	716	32	to	to	TO
cord-336510-qzm9wgde	716	33	clear	clear	JJ
cord-336510-qzm9wgde	716	34	vaccinia	vaccinia	NN
cord-336510-qzm9wgde	716	35	virus	virus	NN
cord-336510-qzm9wgde	716	36	infection	infection	NN
cord-336510-qzm9wgde	716	37	:	:	:
cord-336510-qzm9wgde	716	38	involvement	involvement	NN
cord-336510-qzm9wgde	716	39	of	of	IN
cord-336510-qzm9wgde	716	40	innate	innate	JJ
cord-336510-qzm9wgde	716	41	and	and	CC
cord-336510-qzm9wgde	716	42	adaptive	adaptive	JJ
cord-336510-qzm9wgde	716	43	components	component	NNS
cord-336510-qzm9wgde	716	44	of	of	IN
cord-336510-qzm9wgde	716	45	the	the	DT
cord-336510-qzm9wgde	716	46	immune	immune	JJ
cord-336510-qzm9wgde	716	47	system	system	NN
cord-336510-qzm9wgde	717	1	Reduced	reduce	VBN
cord-336510-qzm9wgde	717	2	severity	severity	NN
cord-336510-qzm9wgde	717	3	of	of	IN
cord-336510-qzm9wgde	717	4	HSV-1-induced	hsv-1-induced	JJ
cord-336510-qzm9wgde	717	5	corneal	corneal	JJ
cord-336510-qzm9wgde	717	6	scarring	scarring	NN
cord-336510-qzm9wgde	717	7	in	in	IN
cord-336510-qzm9wgde	717	8	IL-12-deficient	IL-12-deficient	NNP
cord-336510-qzm9wgde	717	9	mice	mice	NN
cord-336510-qzm9wgde	717	10	IL-12	IL-12	NNP
cord-336510-qzm9wgde	717	11	suppresses	suppress	VBZ
cord-336510-qzm9wgde	717	12	the	the	DT
cord-336510-qzm9wgde	717	13	expression	expression	NN
cord-336510-qzm9wgde	717	14	of	of	IN
cord-336510-qzm9wgde	717	15	ocular	ocular	JJ
cord-336510-qzm9wgde	717	16	immunoinflammatory	immunoinflammatory	NN
cord-336510-qzm9wgde	717	17	lesions	lesion	NNS
cord-336510-qzm9wgde	717	18	by	by	IN
cord-336510-qzm9wgde	717	19	effects	effect	NNS
cord-336510-qzm9wgde	717	20	on	on	IN
cord-336510-qzm9wgde	717	21	angiogenesis	angiogenesis	NN
cord-336510-qzm9wgde	717	22	Therapeutic	therapeutic	JJ
cord-336510-qzm9wgde	717	23	protective	protective	JJ
cord-336510-qzm9wgde	717	24	effects	effect	NNS
cord-336510-qzm9wgde	717	25	of	of	IN
cord-336510-qzm9wgde	717	26	IL-12	IL-12	NNP
cord-336510-qzm9wgde	717	27	combined	combine	VBN
cord-336510-qzm9wgde	717	28	with	with	IN
cord-336510-qzm9wgde	717	29	soluble	soluble	JJ
cord-336510-qzm9wgde	717	30	IL-4	IL-4	NNP
cord-336510-qzm9wgde	717	31	receptor	receptor	NN
cord-336510-qzm9wgde	717	32	against	against	IN
cord-336510-qzm9wgde	717	33	established	establish	VBN
cord-336510-qzm9wgde	717	34	infections	infection	NNS
cord-336510-qzm9wgde	717	35	of	of	IN
cord-336510-qzm9wgde	717	36	herpes	herpes	NN
cord-336510-qzm9wgde	717	37	simplex	simplex	NNP
cord-336510-qzm9wgde	717	38	virus	virus	NN
cord-336510-qzm9wgde	717	39	type	type	NN
cord-336510-qzm9wgde	717	40	1	1	CD
cord-336510-qzm9wgde	717	41	in	in	IN
cord-336510-qzm9wgde	717	42	thermally	thermally	RB
cord-336510-qzm9wgde	717	43	injured	injured	JJ
cord-336510-qzm9wgde	717	44	mice	mice	NN
cord-336510-qzm9wgde	717	45	Requirement	Requirement	NNP
cord-336510-qzm9wgde	717	46	for	for	IN
cord-336510-qzm9wgde	717	47	natural	natural	JJ
cord-336510-qzm9wgde	717	48	killer	killer	NN
cord-336510-qzm9wgde	717	49	cell	cell	NN
cord-336510-qzm9wgde	717	50	-	-	HYPH
cord-336510-qzm9wgde	717	51	produced	produce	VBN
cord-336510-qzm9wgde	717	52	interferon	interferon	NN
cord-336510-qzm9wgde	717	53	gamma	gamma	NN
cord-336510-qzm9wgde	717	54	in	in	IN
cord-336510-qzm9wgde	717	55	defense	defense	NN
cord-336510-qzm9wgde	717	56	against	against	IN
cord-336510-qzm9wgde	717	57	murine	murine	JJ
cord-336510-qzm9wgde	717	58	cytomegalovirus	cytomegalovirus	JJ
cord-336510-qzm9wgde	717	59	infection	infection	NN
cord-336510-qzm9wgde	717	60	and	and	CC
cord-336510-qzm9wgde	717	61	enhancement	enhancement	NN
cord-336510-qzm9wgde	717	62	of	of	IN
cord-336510-qzm9wgde	717	63	this	this	DT
cord-336510-qzm9wgde	717	64	defense	defense	NN
cord-336510-qzm9wgde	717	65	pathway	pathway	NN
cord-336510-qzm9wgde	717	66	by	by	IN
cord-336510-qzm9wgde	717	67	interleukin	interleukin	NN
cord-336510-qzm9wgde	717	68	12	12	CD
cord-336510-qzm9wgde	717	69	administration	administration	NN
cord-336510-qzm9wgde	718	1	An	an	DT
cord-336510-qzm9wgde	718	2	absolute	absolute	JJ
cord-336510-qzm9wgde	718	3	and	and	CC
cord-336510-qzm9wgde	718	4	restricted	restricted	JJ
cord-336510-qzm9wgde	718	5	requirement	requirement	NN
cord-336510-qzm9wgde	718	6	for	for	IN
cord-336510-qzm9wgde	718	7	IL-12	IL-12	NNP
cord-336510-qzm9wgde	718	8	in	in	IN
cord-336510-qzm9wgde	718	9	natural	natural	JJ
cord-336510-qzm9wgde	718	10	killer	killer	NN
cord-336510-qzm9wgde	718	11	cell	cell	NN
cord-336510-qzm9wgde	718	12	IFN	IFN	NNP
cord-336510-qzm9wgde	718	13	-	-	HYPH
cord-336510-qzm9wgde	718	14	gamma	gamma	NN
cord-336510-qzm9wgde	718	15	production	production	NN
cord-336510-qzm9wgde	718	16	and	and	CC
cord-336510-qzm9wgde	718	17	antiviral	antiviral	JJ
cord-336510-qzm9wgde	718	18	defense	defense	NN
cord-336510-qzm9wgde	718	19	.	.	.
cord-336510-qzm9wgde	719	1	Studies	study	NNS
cord-336510-qzm9wgde	719	2	of	of	IN
cord-336510-qzm9wgde	719	3	natural	natural	JJ
cord-336510-qzm9wgde	719	4	killer	killer	NN
cord-336510-qzm9wgde	719	5	and	and	CC
cord-336510-qzm9wgde	719	6	T	T	NNP
cord-336510-qzm9wgde	719	7	cell	cell	NN
cord-336510-qzm9wgde	719	8	responses	response	NNS
cord-336510-qzm9wgde	719	9	in	in	IN
cord-336510-qzm9wgde	719	10	contrasting	contrast	VBG
cord-336510-qzm9wgde	719	11	viral	viral	JJ
cord-336510-qzm9wgde	719	12	infections	infection	NNS
cord-336510-qzm9wgde	719	13	Interleukin-15	Interleukin-15	NNPS
cord-336510-qzm9wgde	719	14	and	and	CC
cord-336510-qzm9wgde	719	15	natural	natural	JJ
cord-336510-qzm9wgde	719	16	killer	killer	NN
cord-336510-qzm9wgde	719	17	and	and	CC
cord-336510-qzm9wgde	719	18	NKT	NKT	NNP
cord-336510-qzm9wgde	719	19	cells	cell	NNS
cord-336510-qzm9wgde	719	20	play	play	VBP
cord-336510-qzm9wgde	719	21	a	a	DT
cord-336510-qzm9wgde	719	22	critical	critical	JJ
cord-336510-qzm9wgde	719	23	role	role	NN
cord-336510-qzm9wgde	719	24	in	in	IN
cord-336510-qzm9wgde	719	25	innate	innate	JJ
cord-336510-qzm9wgde	719	26	protection	protection	NN
cord-336510-qzm9wgde	719	27	against	against	IN
cord-336510-qzm9wgde	719	28	genital	genital	JJ
cord-336510-qzm9wgde	719	29	herpes	herpes	NNP
cord-336510-qzm9wgde	719	30	simplex	simplex	NN
cord-336510-qzm9wgde	719	31	virus	virus	NN
cord-336510-qzm9wgde	719	32	type	type	NN
cord-336510-qzm9wgde	719	33	2	2	CD
cord-336510-qzm9wgde	719	34	infection	infection	NN
cord-336510-qzm9wgde	720	1	In	in	IN
cord-336510-qzm9wgde	720	2	the	the	DT
cord-336510-qzm9wgde	720	3	absence	absence	NN
cord-336510-qzm9wgde	720	4	of	of	IN
cord-336510-qzm9wgde	720	5	T	t	NN
cord-336510-qzm9wgde	720	6	cells	cell	NNS
cord-336510-qzm9wgde	720	7	,	,	,
cord-336510-qzm9wgde	720	8	natural	natural	JJ
cord-336510-qzm9wgde	720	9	killer	killer	NN
cord-336510-qzm9wgde	720	10	cells	cell	NNS
cord-336510-qzm9wgde	720	11	protect	protect	VBP
cord-336510-qzm9wgde	720	12	from	from	IN
cord-336510-qzm9wgde	720	13	mortality	mortality	NN
cord-336510-qzm9wgde	720	14	due	due	IN
cord-336510-qzm9wgde	720	15	to	to	IN
cord-336510-qzm9wgde	721	1	HSV-1	hsv-1	NN
cord-336510-qzm9wgde	721	2	encephalitis	encephalitis	RB
cord-336510-qzm9wgde	721	3	Protective	protective	JJ
cord-336510-qzm9wgde	721	4	immunity	immunity	NN
cord-336510-qzm9wgde	721	5	to	to	IN
cord-336510-qzm9wgde	721	6	genital	genital	JJ
cord-336510-qzm9wgde	721	7	herpes	herpes	NN
cord-336510-qzm9wgde	721	8	simpex	simpex	NN
cord-336510-qzm9wgde	721	9	virus	virus	NN
cord-336510-qzm9wgde	721	10	type	type	NN
cord-336510-qzm9wgde	721	11	2	2	CD
cord-336510-qzm9wgde	721	12	infection	infection	NN
cord-336510-qzm9wgde	721	13	is	be	VBZ
cord-336510-qzm9wgde	721	14	mediated	mediate	VBN
cord-336510-qzm9wgde	721	15	by	by	IN
cord-336510-qzm9wgde	721	16	T	t	NN
cord-336510-qzm9wgde	721	17	-	-	HYPH
cord-336510-qzm9wgde	721	18	bet	bet	NN
cord-336510-qzm9wgde	721	19	The	the	DT
cord-336510-qzm9wgde	721	20	role	role	NN
cord-336510-qzm9wgde	721	21	of	of	IN
cord-336510-qzm9wgde	721	22	natural	natural	JJ
cord-336510-qzm9wgde	721	23	killer	killer	NN
cord-336510-qzm9wgde	721	24	cells	cell	NNS
cord-336510-qzm9wgde	721	25	in	in	IN
cord-336510-qzm9wgde	721	26	protection	protection	NN
cord-336510-qzm9wgde	721	27	of	of	IN
cord-336510-qzm9wgde	721	28	mice	mouse	NNS
cord-336510-qzm9wgde	721	29	against	against	IN
cord-336510-qzm9wgde	721	30	death	death	NN
cord-336510-qzm9wgde	721	31	and	and	CC
cord-336510-qzm9wgde	721	32	corneal	corneal	JJ
cord-336510-qzm9wgde	721	33	scarring	scarring	NN
cord-336510-qzm9wgde	721	34	following	follow	VBG
cord-336510-qzm9wgde	721	35	ocular	ocular	JJ
cord-336510-qzm9wgde	721	36	HSV-1	HSV-1	NNP
cord-336510-qzm9wgde	721	37	infection	infection	NN
cord-336510-qzm9wgde	721	38	Kinetics	kinetic	NNS
cord-336510-qzm9wgde	721	39	of	of	IN
cord-336510-qzm9wgde	721	40	cytokine	cytokine	NN
cord-336510-qzm9wgde	721	41	production	production	NN
cord-336510-qzm9wgde	721	42	in	in	IN
cord-336510-qzm9wgde	721	43	the	the	DT
cord-336510-qzm9wgde	721	44	cornea	cornea	NN
cord-336510-qzm9wgde	721	45	and	and	CC
cord-336510-qzm9wgde	721	46	trigeminal	trigeminal	JJ
cord-336510-qzm9wgde	721	47	ganglion	ganglion	NN
cord-336510-qzm9wgde	721	48	of	of	IN
cord-336510-qzm9wgde	721	49	C57BL/6	C57BL/6	NNP
cord-336510-qzm9wgde	721	50	mice	mouse	NNS
cord-336510-qzm9wgde	721	51	after	after	IN
cord-336510-qzm9wgde	721	52	corneal	corneal	JJ
cord-336510-qzm9wgde	721	53	HSV-1	HSV-1	NNP
cord-336510-qzm9wgde	721	54	infection	infection	NN
cord-336510-qzm9wgde	721	55	Human	Human	NNP
cord-336510-qzm9wgde	721	56	natural	natural	JJ
cord-336510-qzm9wgde	721	57	killer	killer	NN
cord-336510-qzm9wgde	721	58	cell	cell	NN
cord-336510-qzm9wgde	721	59	deficiencies	deficiency	NNS
cord-336510-qzm9wgde	721	60	and	and	CC
cord-336510-qzm9wgde	721	61	susceptibility	susceptibility	NN
cord-336510-qzm9wgde	721	62	to	to	IN
cord-336510-qzm9wgde	721	63	infection	infection	NN
cord-336510-qzm9wgde	721	64	Nitric	nitric	NN
cord-336510-qzm9wgde	721	65	oxide	oxide	NN
cord-336510-qzm9wgde	721	66	as	as	IN
cord-336510-qzm9wgde	721	67	a	a	DT
cord-336510-qzm9wgde	721	68	secretory	secretory	JJ
cord-336510-qzm9wgde	721	69	product	product	NN
cord-336510-qzm9wgde	721	70	of	of	IN
cord-336510-qzm9wgde	721	71	mammalian	mammalian	JJ
cord-336510-qzm9wgde	721	72	cells	cell	NNS
cord-336510-qzm9wgde	721	73	Herpes	Herpes	NNP
cord-336510-qzm9wgde	721	74	simplex	simplex	NN
cord-336510-qzm9wgde	721	75	virus	virus	NN
cord-336510-qzm9wgde	721	76	type	type	NN
cord-336510-qzm9wgde	721	77	2	2	CD
cord-336510-qzm9wgde	721	78	synergizes	synergize	VBZ
cord-336510-qzm9wgde	721	79	with	with	IN
cord-336510-qzm9wgde	721	80	interferon	interferon	NN
cord-336510-qzm9wgde	721	81	-	-	HYPH
cord-336510-qzm9wgde	721	82	gamma	gamma	NN
cord-336510-qzm9wgde	721	83	in	in	IN
cord-336510-qzm9wgde	721	84	the	the	DT
cord-336510-qzm9wgde	721	85	induction	induction	NN
cord-336510-qzm9wgde	721	86	of	of	IN
cord-336510-qzm9wgde	721	87	nitric	nitric	JJ
cord-336510-qzm9wgde	721	88	oxide	oxide	NN
cord-336510-qzm9wgde	721	89	production	production	NN
cord-336510-qzm9wgde	721	90	in	in	IN
cord-336510-qzm9wgde	721	91	mouse	mouse	NN
cord-336510-qzm9wgde	721	92	macrophages	macrophage	NNS
cord-336510-qzm9wgde	721	93	through	through	IN
cord-336510-qzm9wgde	721	94	autocrine	autocrine	JJ
cord-336510-qzm9wgde	721	95	secretion	secretion	NN
cord-336510-qzm9wgde	721	96	of	of	IN
cord-336510-qzm9wgde	721	97	tumour	tumour	NN
cord-336510-qzm9wgde	721	98	necrosis	necrosis	NN
cord-336510-qzm9wgde	721	99	factor	factor	NN
cord-336510-qzm9wgde	721	100	-	-	HYPH
cord-336510-qzm9wgde	721	101	alpha	alpha	NN
cord-336510-qzm9wgde	721	102	Production	production	NN
cord-336510-qzm9wgde	721	103	of	of	IN
cord-336510-qzm9wgde	721	104	key	key	JJ
cord-336510-qzm9wgde	721	105	molecules	molecule	NNS
cord-336510-qzm9wgde	721	106	by	by	IN
cord-336510-qzm9wgde	721	107	ocular	ocular	JJ
cord-336510-qzm9wgde	721	108	neutrophils	neutrophil	NNS
cord-336510-qzm9wgde	721	109	early	early	RB
cord-336510-qzm9wgde	721	110	after	after	IN
cord-336510-qzm9wgde	721	111	herpetic	herpetic	JJ
cord-336510-qzm9wgde	721	112	infection	infection	NN
cord-336510-qzm9wgde	721	113	of	of	IN
cord-336510-qzm9wgde	721	114	the	the	DT
cord-336510-qzm9wgde	721	115	cornea	cornea	NN
cord-336510-qzm9wgde	721	116	Requirement	Requirement	NNP
cord-336510-qzm9wgde	721	117	for	for	IN
cord-336510-qzm9wgde	721	118	type	type	NN
cord-336510-qzm9wgde	721	119	2	2	CD
cord-336510-qzm9wgde	721	120	NO	no	DT
cord-336510-qzm9wgde	721	121	synthase	synthase	NN
cord-336510-qzm9wgde	721	122	for	for	IN
cord-336510-qzm9wgde	721	123	IL-12	IL-12	NNP
cord-336510-qzm9wgde	721	124	signaling	signal	VBG
cord-336510-qzm9wgde	721	125	in	in	IN
cord-336510-qzm9wgde	721	126	innate	innate	JJ
cord-336510-qzm9wgde	721	127	immunity	immunity	NN
cord-336510-qzm9wgde	721	128	Absence	absence	NN
cord-336510-qzm9wgde	721	129	of	of	IN
cord-336510-qzm9wgde	721	130	tumour	tumour	NN
cord-336510-qzm9wgde	721	131	necrosis	necrosis	NN
cord-336510-qzm9wgde	721	132	factor	factor	NN
cord-336510-qzm9wgde	721	133	facilitates	facilitate	VBZ
cord-336510-qzm9wgde	721	134	primary	primary	JJ
cord-336510-qzm9wgde	721	135	and	and	CC
cord-336510-qzm9wgde	721	136	recurrent	recurrent	JJ
cord-336510-qzm9wgde	721	137	herpes	herpes	NN
cord-336510-qzm9wgde	721	138	simplex	simplex	NN
cord-336510-qzm9wgde	721	139	virus-1	virus-1	NNP
cord-336510-qzm9wgde	721	140	infections	infection	NNS
cord-336510-qzm9wgde	721	141	Macrophage	Macrophage	NNP
cord-336510-qzm9wgde	721	142	control	control	NN
cord-336510-qzm9wgde	721	143	of	of	IN
cord-336510-qzm9wgde	721	144	herpes	herpes	NNP
cord-336510-qzm9wgde	721	145	simplex	simplex	NNP
cord-336510-qzm9wgde	721	146	virus	virus	NN
cord-336510-qzm9wgde	721	147	type	type	NN
cord-336510-qzm9wgde	721	148	1	1	CD
cord-336510-qzm9wgde	721	149	replication	replication	NN
cord-336510-qzm9wgde	721	150	in	in	IN
cord-336510-qzm9wgde	721	151	the	the	DT
cord-336510-qzm9wgde	721	152	peripheral	peripheral	JJ
cord-336510-qzm9wgde	721	153	nervous	nervous	JJ
cord-336510-qzm9wgde	721	154	system	system	NN
cord-336510-qzm9wgde	721	155	Nitric	nitric	NN
cord-336510-qzm9wgde	721	156	oxide	oxide	NN
cord-336510-qzm9wgde	721	157	and	and	CC
cord-336510-qzm9wgde	721	158	HSV	HSV	NNP
cord-336510-qzm9wgde	721	159	vaginal	vaginal	JJ
cord-336510-qzm9wgde	721	160	infection	infection	NN
cord-336510-qzm9wgde	721	161	in	in	IN
cord-336510-qzm9wgde	721	162	BALB	BALB	NNP
cord-336510-qzm9wgde	721	163	/	/	SYM
cord-336510-qzm9wgde	721	164	c	c	NN
cord-336510-qzm9wgde	721	165	mice	mouse	NNS
cord-336510-qzm9wgde	722	1	Interferon	interferon	NN
cord-336510-qzm9wgde	723	1	(	(	-LRB-
cord-336510-qzm9wgde	723	2	IFN)-gamma	ifn)-gamma	JJ
cord-336510-qzm9wgde	723	3	and	and	CC
cord-336510-qzm9wgde	723	4	Herpes	Herpes	NNP
cord-336510-qzm9wgde	723	5	simplex	simplex	NN
cord-336510-qzm9wgde	723	6	virus	virus	NN
cord-336510-qzm9wgde	723	7	/	/	SYM
cord-336510-qzm9wgde	723	8	tumor	tumor	NN
cord-336510-qzm9wgde	723	9	necrosis	necrosis	NN
cord-336510-qzm9wgde	723	10	factor	factor	NN
cord-336510-qzm9wgde	723	11	-	-	HYPH
cord-336510-qzm9wgde	723	12	alpha	alpha	NN
cord-336510-qzm9wgde	723	13	synergistically	synergistically	RB
cord-336510-qzm9wgde	723	14	induce	induce	VBP
cord-336510-qzm9wgde	723	15	nitric	nitric	NN
cord-336510-qzm9wgde	723	16	oxide	oxide	NN
cord-336510-qzm9wgde	723	17	synthase	synthase	NN
cord-336510-qzm9wgde	723	18	2	2	CD
cord-336510-qzm9wgde	723	19	in	in	IN
cord-336510-qzm9wgde	723	20	macrophages	macrophage	NNS
cord-336510-qzm9wgde	723	21	through	through	IN
cord-336510-qzm9wgde	723	22	cooperative	cooperative	JJ
cord-336510-qzm9wgde	723	23	action	action	NN
cord-336510-qzm9wgde	723	24	of	of	IN
cord-336510-qzm9wgde	723	25	nuclear	nuclear	JJ
cord-336510-qzm9wgde	723	26	factor	factor	NN
cord-336510-qzm9wgde	723	27	-	-	HYPH
cord-336510-qzm9wgde	723	28	kappa	kappa	NN
cord-336510-qzm9wgde	723	29	B	B	NNP
cord-336510-qzm9wgde	723	30	and	and	CC
cord-336510-qzm9wgde	723	31	IFN	IFN	NNP
cord-336510-qzm9wgde	723	32	regulatory	regulatory	JJ
cord-336510-qzm9wgde	723	33	factor-1	factor-1	NNP
cord-336510-qzm9wgde	723	34	Requirement	Requirement	NNP
cord-336510-qzm9wgde	723	35	for	for	IN
cord-336510-qzm9wgde	723	36	transcription	transcription	NN
cord-336510-qzm9wgde	723	37	factor	factor	NN
cord-336510-qzm9wgde	724	1	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	724	2	in	in	IN
cord-336510-qzm9wgde	724	3	NO	no	DT
cord-336510-qzm9wgde	724	4	synthase	synthase	NN
cord-336510-qzm9wgde	724	5	induction	induction	NN
cord-336510-qzm9wgde	724	6	in	in	IN
cord-336510-qzm9wgde	724	7	macrophages	macrophage	NNS
cord-336510-qzm9wgde	724	8	Endothelial	endothelial	JJ
cord-336510-qzm9wgde	725	1	interferon	interferon	NNP
cord-336510-qzm9wgde	725	2	regulatory	regulatory	JJ
cord-336510-qzm9wgde	725	3	factor	factor	NN
cord-336510-qzm9wgde	725	4	1	1	CD
cord-336510-qzm9wgde	725	5	cooperates	cooperate	VBZ
cord-336510-qzm9wgde	725	6	with	with	IN
cord-336510-qzm9wgde	725	7	NF	nf	NN
cord-336510-qzm9wgde	725	8	-	-	HYPH
cord-336510-qzm9wgde	725	9	kappa	kappa	NN
cord-336510-qzm9wgde	725	10	B	B	NNP
cord-336510-qzm9wgde	725	11	as	as	IN
cord-336510-qzm9wgde	725	12	a	a	DT
cord-336510-qzm9wgde	725	13	transcriptional	transcriptional	JJ
cord-336510-qzm9wgde	725	14	activator	activator	NN
cord-336510-qzm9wgde	725	15	of	of	IN
cord-336510-qzm9wgde	725	16	vascular	vascular	JJ
cord-336510-qzm9wgde	725	17	cell	cell	NN
cord-336510-qzm9wgde	725	18	adhesion	adhesion	NN
cord-336510-qzm9wgde	725	19	molecule	molecule	NN
cord-336510-qzm9wgde	725	20	1	1	CD
cord-336510-qzm9wgde	725	21	NF	NF	NNP
cord-336510-qzm9wgde	725	22	kappa	kappa	NN
cord-336510-qzm9wgde	725	23	B	b	NN
cord-336510-qzm9wgde	725	24	and	and	CC
cord-336510-qzm9wgde	725	25	interferon	interferon	NN
cord-336510-qzm9wgde	725	26	regulatory	regulatory	JJ
cord-336510-qzm9wgde	725	27	factor	factor	NN
cord-336510-qzm9wgde	725	28	1	1	CD
cord-336510-qzm9wgde	725	29	physically	physically	RB
cord-336510-qzm9wgde	725	30	interact	interact	VBP
cord-336510-qzm9wgde	725	31	and	and	CC
cord-336510-qzm9wgde	725	32	synergistically	synergistically	RB
cord-336510-qzm9wgde	725	33	induce	induce	VB
cord-336510-qzm9wgde	725	34	major	major	JJ
cord-336510-qzm9wgde	725	35	histocompatibility	histocompatibility	NN
cord-336510-qzm9wgde	725	36	class	class	NN
cord-336510-qzm9wgde	725	37	I	-PRON-	PRP
cord-336510-qzm9wgde	725	38	gene	gene	NN
cord-336510-qzm9wgde	725	39	expression	expression	NN
cord-336510-qzm9wgde	726	1	Interferon	interferon	NN
cord-336510-qzm9wgde	726	2	regulatory	regulatory	JJ
cord-336510-qzm9wgde	726	3	factor-2	factor-2	NNP
cord-336510-qzm9wgde	726	4	physically	physically	RB
cord-336510-qzm9wgde	726	5	interacts	interact	VBZ
cord-336510-qzm9wgde	726	6	with	with	IN
cord-336510-qzm9wgde	726	7	NF	nf	NN
cord-336510-qzm9wgde	726	8	-	-	HYPH
cord-336510-qzm9wgde	726	9	kappa	kappa	NN
cord-336510-qzm9wgde	726	10	B	b	NN
cord-336510-qzm9wgde	726	11	in	in	IN
cord-336510-qzm9wgde	726	12	vitro	vitro	FW
cord-336510-qzm9wgde	726	13	and	and	CC
cord-336510-qzm9wgde	726	14	inhibits	inhibit	NNS
cord-336510-qzm9wgde	727	1	NF	nf	NN
cord-336510-qzm9wgde	727	2	-	-	HYPH
cord-336510-qzm9wgde	727	3	kappa	kappa	NN
cord-336510-qzm9wgde	727	4	B	B	NNP
cord-336510-qzm9wgde	727	5	induction	induction	NN
cord-336510-qzm9wgde	727	6	of	of	IN
cord-336510-qzm9wgde	727	7	major	major	JJ
cord-336510-qzm9wgde	727	8	histocompatibility	histocompatibility	NN
cord-336510-qzm9wgde	727	9	class	class	NN
cord-336510-qzm9wgde	727	10	I	i	NN
cord-336510-qzm9wgde	727	11	and	and	CC
cord-336510-qzm9wgde	727	12	beta	beta	NN
cord-336510-qzm9wgde	727	13	2-microglobulin	2-microglobulin	CD
cord-336510-qzm9wgde	727	14	gene	gene	NN
cord-336510-qzm9wgde	727	15	expression	expression	NN
cord-336510-qzm9wgde	727	16	in	in	IN
cord-336510-qzm9wgde	727	17	transfected	transfecte	VBN
cord-336510-qzm9wgde	727	18	human	human	JJ
cord-336510-qzm9wgde	727	19	neuroblastoma	neuroblastoma	NN
cord-336510-qzm9wgde	727	20	cells	cell	NNS
cord-336510-qzm9wgde	727	21	Complex	complex	JJ
cord-336510-qzm9wgde	727	22	formation	formation	NN
cord-336510-qzm9wgde	727	23	of	of	IN
cord-336510-qzm9wgde	727	24	the	the	DT
cord-336510-qzm9wgde	727	25	interferon	interferon	NN
cord-336510-qzm9wgde	727	26	(	(	-LRB-
cord-336510-qzm9wgde	727	27	IFN	IFN	NNP
cord-336510-qzm9wgde	727	28	)	)	-RRB-
cord-336510-qzm9wgde	727	29	consensus	consensus	NN
cord-336510-qzm9wgde	727	30	sequence	sequence	NN
cord-336510-qzm9wgde	727	31	-	-	HYPH
cord-336510-qzm9wgde	727	32	binding	bind	VBG
cord-336510-qzm9wgde	727	33	protein	protein	NN
cord-336510-qzm9wgde	727	34	with	with	IN
cord-336510-qzm9wgde	727	35	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	727	36	is	be	VBZ
cord-336510-qzm9wgde	727	37	essential	essential	JJ
cord-336510-qzm9wgde	727	38	for	for	IN
cord-336510-qzm9wgde	727	39	murine	murine	JJ
cord-336510-qzm9wgde	727	40	macrophage	macrophage	NN
cord-336510-qzm9wgde	727	41	IFN	IFN	NNP
cord-336510-qzm9wgde	727	42	-	-	HYPH
cord-336510-qzm9wgde	727	43	gamma	gamma	NN
cord-336510-qzm9wgde	727	44	-	-	HYPH
cord-336510-qzm9wgde	727	45	induced	induce	VBN
cord-336510-qzm9wgde	727	46	iNOS	inos	JJ
cord-336510-qzm9wgde	727	47	gene	gene	NN
cord-336510-qzm9wgde	727	48	expression	expression	NN
cord-336510-qzm9wgde	727	49	Does	do	VBZ
cord-336510-qzm9wgde	727	50	nitric	nitric	NN
cord-336510-qzm9wgde	727	51	oxide	oxide	NN
cord-336510-qzm9wgde	727	52	play	play	VB
cord-336510-qzm9wgde	727	53	a	a	DT
cord-336510-qzm9wgde	727	54	critical	critical	JJ
cord-336510-qzm9wgde	727	55	role	role	NN
cord-336510-qzm9wgde	727	56	in	in	IN
cord-336510-qzm9wgde	727	57	viral	viral	JJ
cord-336510-qzm9wgde	727	58	infections	infection	NNS
cord-336510-qzm9wgde	727	59	?	?	.
cord-336510-qzm9wgde	728	1	Inhibition	inhibition	NN
cord-336510-qzm9wgde	728	2	of	of	IN
cord-336510-qzm9wgde	728	3	viral	viral	JJ
cord-336510-qzm9wgde	728	4	replication	replication	NN
cord-336510-qzm9wgde	728	5	by	by	IN
cord-336510-qzm9wgde	728	6	interferon	interferon	NN
cord-336510-qzm9wgde	728	7	-	-	HYPH
cord-336510-qzm9wgde	728	8	gammainduced	gammainduce	VBN
cord-336510-qzm9wgde	728	9	nitric	nitric	NN
cord-336510-qzm9wgde	728	10	oxide	oxide	NN
cord-336510-qzm9wgde	728	11	synthase	synthase	NN
cord-336510-qzm9wgde	728	12	Interferon	interferon	NN
cord-336510-qzm9wgde	728	13	-	-	HYPH
cord-336510-qzm9wgde	728	14	gamma	gamma	NN
cord-336510-qzm9wgde	728	15	induced	induce	VBN
cord-336510-qzm9wgde	728	16	type	type	NN
cord-336510-qzm9wgde	729	1	I	-PRON-	PRP
cord-336510-qzm9wgde	729	2	nitric	nitric	JJ
cord-336510-qzm9wgde	729	3	oxide	oxide	NN
cord-336510-qzm9wgde	729	4	synthase	synthase	NN
cord-336510-qzm9wgde	729	5	activity	activity	NN
cord-336510-qzm9wgde	729	6	inhibits	inhibit	VBZ
cord-336510-qzm9wgde	729	7	viral	viral	JJ
cord-336510-qzm9wgde	729	8	replication	replication	NN
cord-336510-qzm9wgde	729	9	in	in	IN
cord-336510-qzm9wgde	729	10	neurons	neuron	NNS
cord-336510-qzm9wgde	729	11	Inhibition	inhibition	NN
cord-336510-qzm9wgde	729	12	of	of	IN
cord-336510-qzm9wgde	729	13	viral	viral	JJ
cord-336510-qzm9wgde	729	14	replication	replication	NN
cord-336510-qzm9wgde	729	15	by	by	IN
cord-336510-qzm9wgde	729	16	nitric	nitric	NN
cord-336510-qzm9wgde	729	17	oxide	oxide	NN
cord-336510-qzm9wgde	729	18	and	and	CC
cord-336510-qzm9wgde	729	19	its	-PRON-	PRP$
cord-336510-qzm9wgde	729	20	reversal	reversal	NN
cord-336510-qzm9wgde	729	21	by	by	IN
cord-336510-qzm9wgde	729	22	ferrous	ferrous	JJ
cord-336510-qzm9wgde	729	23	sulfate	sulfate	NN
cord-336510-qzm9wgde	729	24	and	and	CC
cord-336510-qzm9wgde	729	25	tricarboxylic	tricarboxylic	JJ
cord-336510-qzm9wgde	729	26	acid	acid	NN
cord-336510-qzm9wgde	729	27	cycle	cycle	NN
cord-336510-qzm9wgde	729	28	metabolites	metabolite	NNS
cord-336510-qzm9wgde	730	1	Nitric	nitric	NN
cord-336510-qzm9wgde	730	2	oxide	oxide	NN
cord-336510-qzm9wgde	730	3	and	and	CC
cord-336510-qzm9wgde	730	4	macrophage	macrophage	NN
cord-336510-qzm9wgde	730	5	antiviral	antiviral	JJ
cord-336510-qzm9wgde	730	6	extrinsic	extrinsic	NN
cord-336510-qzm9wgde	730	7	activity	activity	NN
cord-336510-qzm9wgde	730	8	Evidence	evidence	NN
cord-336510-qzm9wgde	730	9	for	for	IN
cord-336510-qzm9wgde	730	10	antiviral	antiviral	JJ
cord-336510-qzm9wgde	730	11	effect	effect	NN
cord-336510-qzm9wgde	730	12	of	of	IN
cord-336510-qzm9wgde	730	13	nitric	nitric	JJ
cord-336510-qzm9wgde	730	14	oxide	oxide	NN
cord-336510-qzm9wgde	730	15	.	.	.
cord-336510-qzm9wgde	731	1	Inhibition	inhibition	NN
cord-336510-qzm9wgde	731	2	of	of	IN
cord-336510-qzm9wgde	731	3	herpes	herpes	NNP
cord-336510-qzm9wgde	731	4	simplex	simplex	NNP
cord-336510-qzm9wgde	731	5	virus	virus	NN
cord-336510-qzm9wgde	731	6	type	type	NN
cord-336510-qzm9wgde	731	7	1	1	CD
cord-336510-qzm9wgde	731	8	replication	replication	NN
cord-336510-qzm9wgde	732	1	Early	early	JJ
cord-336510-qzm9wgde	732	2	inhibition	inhibition	NN
cord-336510-qzm9wgde	732	3	of	of	IN
cord-336510-qzm9wgde	732	4	nitric	nitric	JJ
cord-336510-qzm9wgde	732	5	oxide	oxide	NN
cord-336510-qzm9wgde	732	6	production	production	NN
cord-336510-qzm9wgde	732	7	increases	increase	VBZ
cord-336510-qzm9wgde	732	8	HSV-1	hsv-1	RB
cord-336510-qzm9wgde	733	1	intranasal	intranasal	NN
cord-336510-qzm9wgde	733	2	infection	infection	NN
cord-336510-qzm9wgde	733	3	Role	role	NN
cord-336510-qzm9wgde	733	4	of	of	IN
cord-336510-qzm9wgde	733	5	nitric	nitric	JJ
cord-336510-qzm9wgde	733	6	oxide	oxide	NN
cord-336510-qzm9wgde	733	7	synthase	synthase	NN
cord-336510-qzm9wgde	733	8	type	type	NN
cord-336510-qzm9wgde	733	9	2	2	CD
cord-336510-qzm9wgde	733	10	in	in	IN
cord-336510-qzm9wgde	733	11	acute	acute	JJ
cord-336510-qzm9wgde	733	12	infection	infection	NN
cord-336510-qzm9wgde	733	13	with	with	IN
cord-336510-qzm9wgde	733	14	murine	murine	JJ
cord-336510-qzm9wgde	733	15	cytomegalovirus	cytomegalovirus	JJ
cord-336510-qzm9wgde	733	16	Mice	mouse	NNS
cord-336510-qzm9wgde	733	17	lacking	lack	VBG
cord-336510-qzm9wgde	734	1	inducible	inducible	JJ
cord-336510-qzm9wgde	734	2	nitric	nitric	JJ
cord-336510-qzm9wgde	734	3	-	-	HYPH
cord-336510-qzm9wgde	734	4	oxide	oxide	NN
cord-336510-qzm9wgde	734	5	synthase	synthase	NN
cord-336510-qzm9wgde	734	6	are	be	VBP
cord-336510-qzm9wgde	734	7	more	more	RBR
cord-336510-qzm9wgde	734	8	susceptible	susceptible	JJ
cord-336510-qzm9wgde	734	9	to	to	IN
cord-336510-qzm9wgde	734	10	herpes	herpes	NN
cord-336510-qzm9wgde	734	11	simplex	simplex	NNP
cord-336510-qzm9wgde	734	12	virus	virus	NN
cord-336510-qzm9wgde	734	13	infection	infection	NN
cord-336510-qzm9wgde	734	14	despite	despite	IN
cord-336510-qzm9wgde	734	15	enhanced	enhanced	JJ
cord-336510-qzm9wgde	734	16	Th1	th1	CD
cord-336510-qzm9wgde	734	17	cell	cell	NN
cord-336510-qzm9wgde	734	18	responses	response	NNS
cord-336510-qzm9wgde	735	1	Phenotype	phenotype	NN
cord-336510-qzm9wgde	735	2	of	of	IN
cord-336510-qzm9wgde	735	3	mice	mouse	NNS
cord-336510-qzm9wgde	735	4	and	and	CC
cord-336510-qzm9wgde	735	5	macrophages	macrophage	NNS
cord-336510-qzm9wgde	735	6	deficient	deficient	JJ
cord-336510-qzm9wgde	735	7	in	in	IN
cord-336510-qzm9wgde	735	8	both	both	DT
cord-336510-qzm9wgde	735	9	phagocyte	phagocyte	NNP
cord-336510-qzm9wgde	735	10	oxidase	oxidase	NN
cord-336510-qzm9wgde	735	11	and	and	CC
cord-336510-qzm9wgde	735	12	inducible	inducible	JJ
cord-336510-qzm9wgde	735	13	nitric	nitric	NN
cord-336510-qzm9wgde	735	14	oxide	oxide	NN
cord-336510-qzm9wgde	735	15	synthase	synthase	NN
cord-336510-qzm9wgde	735	16	EPR	epr	NN
cord-336510-qzm9wgde	735	17	characterization	characterization	NN
cord-336510-qzm9wgde	735	18	of	of	IN
cord-336510-qzm9wgde	735	19	molecular	molecular	JJ
cord-336510-qzm9wgde	735	20	targets	target	NNS
cord-336510-qzm9wgde	735	21	for	for	IN
cord-336510-qzm9wgde	735	22	NO	no	DT
cord-336510-qzm9wgde	735	23	in	in	IN
cord-336510-qzm9wgde	735	24	mammalian	mammalian	JJ
cord-336510-qzm9wgde	735	25	cells	cell	NNS
cord-336510-qzm9wgde	735	26	and	and	CC
cord-336510-qzm9wgde	735	27	organelles	organelle	NNS
cord-336510-qzm9wgde	735	28	DNA	dna	NN
cord-336510-qzm9wgde	735	29	strand	strand	NN
cord-336510-qzm9wgde	735	30	breakage	breakage	NN
cord-336510-qzm9wgde	735	31	,	,	,
cord-336510-qzm9wgde	735	32	activation	activation	NN
cord-336510-qzm9wgde	735	33	of	of	IN
cord-336510-qzm9wgde	735	34	poly	poly	NNP
cord-336510-qzm9wgde	735	35	(	(	-LRB-
cord-336510-qzm9wgde	735	36	ADP	ADP	NNP
cord-336510-qzm9wgde	735	37	-	-	HYPH
cord-336510-qzm9wgde	735	38	ribose	ribose	NN
cord-336510-qzm9wgde	735	39	)	)	-RRB-
cord-336510-qzm9wgde	735	40	synthetase	synthetase	NN
cord-336510-qzm9wgde	735	41	,	,	,
cord-336510-qzm9wgde	735	42	and	and	CC
cord-336510-qzm9wgde	735	43	cellular	cellular	JJ
cord-336510-qzm9wgde	735	44	energy	energy	NN
cord-336510-qzm9wgde	735	45	depletion	depletion	NN
cord-336510-qzm9wgde	736	1	are	be	VBP
cord-336510-qzm9wgde	736	2	involved	involve	VBN
cord-336510-qzm9wgde	736	3	in	in	IN
cord-336510-qzm9wgde	736	4	the	the	DT
cord-336510-qzm9wgde	736	5	cytotoxicity	cytotoxicity	NN
cord-336510-qzm9wgde	736	6	of	of	IN
cord-336510-qzm9wgde	736	7	macrophages	macrophage	NNS
cord-336510-qzm9wgde	736	8	and	and	CC
cord-336510-qzm9wgde	736	9	smooth	smooth	JJ
cord-336510-qzm9wgde	736	10	muscle	muscle	NN
cord-336510-qzm9wgde	736	11	cells	cell	NNS
cord-336510-qzm9wgde	736	12	exposed	expose	VBN
cord-336510-qzm9wgde	736	13	to	to	IN
cord-336510-qzm9wgde	736	14	peroxynitrite	peroxynitrite	NNP
cord-336510-qzm9wgde	736	15	Nitric	nitric	NN
cord-336510-qzm9wgde	736	16	oxide	oxide	NN
cord-336510-qzm9wgde	736	17	regulation	regulation	NN
cord-336510-qzm9wgde	736	18	of	of	IN
cord-336510-qzm9wgde	736	19	superoxide	superoxide	NN
cord-336510-qzm9wgde	736	20	and	and	CC
cord-336510-qzm9wgde	736	21	peroxynitrite	peroxynitrite	JJ
cord-336510-qzm9wgde	736	22	-	-	HYPH
cord-336510-qzm9wgde	736	23	dependent	dependent	JJ
cord-336510-qzm9wgde	736	24	lipid	lipid	NN
cord-336510-qzm9wgde	736	25	peroxidation	peroxidation	NN
cord-336510-qzm9wgde	736	26	.	.	.
cord-336510-qzm9wgde	737	1	Formation	formation	NN
cord-336510-qzm9wgde	737	2	of	of	IN
cord-336510-qzm9wgde	737	3	novel	novel	JJ
cord-336510-qzm9wgde	737	4	nitrogen	nitrogen	NN
cord-336510-qzm9wgde	737	5	-	-	HYPH
cord-336510-qzm9wgde	737	6	containing	contain	VBG
cord-336510-qzm9wgde	737	7	oxidized	oxidize	VBN
cord-336510-qzm9wgde	737	8	lipid	lipid	NN
cord-336510-qzm9wgde	737	9	derivatives	derivative	NNS
cord-336510-qzm9wgde	737	10	Altered	alter	VBD
cord-336510-qzm9wgde	737	11	immune	immune	JJ
cord-336510-qzm9wgde	737	12	responses	response	NNS
cord-336510-qzm9wgde	737	13	in	in	IN
cord-336510-qzm9wgde	737	14	mice	mouse	NNS
cord-336510-qzm9wgde	737	15	lacking	lack	VBG
cord-336510-qzm9wgde	738	1	inducible	inducible	JJ
cord-336510-qzm9wgde	738	2	nitric	nitric	NN
cord-336510-qzm9wgde	738	3	oxide	oxide	NN
cord-336510-qzm9wgde	738	4	synthase	synthase	NN
cord-336510-qzm9wgde	738	5	Rapid	Rapid	NNP
cord-336510-qzm9wgde	738	6	interferon	interferon	NN
cord-336510-qzm9wgde	738	7	gamma	gamma	NN
cord-336510-qzm9wgde	738	8	-	-	HYPH
cord-336510-qzm9wgde	738	9	dependent	dependent	JJ
cord-336510-qzm9wgde	738	10	clearance	clearance	NN
cord-336510-qzm9wgde	738	11	of	of	IN
cord-336510-qzm9wgde	738	12	influenza	influenza	NN
cord-336510-qzm9wgde	738	13	A	a	DT
cord-336510-qzm9wgde	738	14	virus	virus	NN
cord-336510-qzm9wgde	738	15	and	and	CC
cord-336510-qzm9wgde	738	16	protection	protection	NN
cord-336510-qzm9wgde	738	17	from	from	IN
cord-336510-qzm9wgde	738	18	consolidating	consolidate	VBG
cord-336510-qzm9wgde	738	19	pneumonitis	pneumonitis	NN
cord-336510-qzm9wgde	738	20	in	in	IN
cord-336510-qzm9wgde	738	21	nitric	nitric	JJ
cord-336510-qzm9wgde	738	22	oxide	oxide	NN
cord-336510-qzm9wgde	738	23	synthase	synthase	NN
cord-336510-qzm9wgde	738	24	2-deficient	2-deficient	CD
cord-336510-qzm9wgde	738	25	mice	mouse	NNS
cord-336510-qzm9wgde	739	1	Osterhaus	Osterhaus	NNP
cord-336510-qzm9wgde	739	2	AD	ad	NN
cord-336510-qzm9wgde	739	3	:	:	:
cord-336510-qzm9wgde	740	1	Inhibition	inhibition	NN
cord-336510-qzm9wgde	740	2	of	of	IN
cord-336510-qzm9wgde	740	3	influenza	influenza	NN
cord-336510-qzm9wgde	740	4	virus	virus	NN
cord-336510-qzm9wgde	740	5	replication	replication	NN
cord-336510-qzm9wgde	740	6	by	by	IN
cord-336510-qzm9wgde	740	7	nitric	nitric	NN
cord-336510-qzm9wgde	740	8	oxide	oxide	NN
cord-336510-qzm9wgde	740	9	Nitric	nitric	NN
cord-336510-qzm9wgde	740	10	oxide	oxide	NN
cord-336510-qzm9wgde	740	11	inhibits	inhibit	VBZ
cord-336510-qzm9wgde	740	12	the	the	DT
cord-336510-qzm9wgde	740	13	replication	replication	NN
cord-336510-qzm9wgde	740	14	cycle	cycle	NN
cord-336510-qzm9wgde	740	15	of	of	IN
cord-336510-qzm9wgde	740	16	severe	severe	JJ
cord-336510-qzm9wgde	740	17	acute	acute	JJ
cord-336510-qzm9wgde	740	18	respiratory	respiratory	JJ
cord-336510-qzm9wgde	740	19	syndrome	syndrome	NN
cord-336510-qzm9wgde	740	20	coronavirus	coronavirus	NN
cord-336510-qzm9wgde	740	21	Interleukin-4-mediated	interleukin-4-mediate	VBN
cord-336510-qzm9wgde	740	22	inhibition	inhibition	NN
cord-336510-qzm9wgde	740	23	of	of	IN
cord-336510-qzm9wgde	740	24	nitric	nitric	JJ
cord-336510-qzm9wgde	740	25	oxide	oxide	NN
cord-336510-qzm9wgde	740	26	production	production	NN
cord-336510-qzm9wgde	740	27	in	in	IN
cord-336510-qzm9wgde	740	28	interferon	interferon	NN
cord-336510-qzm9wgde	740	29	-	-	HYPH
cord-336510-qzm9wgde	740	30	gamma	gamma	NN
cord-336510-qzm9wgde	740	31	-	-	HYPH
cord-336510-qzm9wgde	740	32	treated	treat	VBN
cord-336510-qzm9wgde	740	33	and	and	CC
cord-336510-qzm9wgde	740	34	virus	virus	NN
cord-336510-qzm9wgde	740	35	-	-	HYPH
cord-336510-qzm9wgde	740	36	infected	infect	VBN
cord-336510-qzm9wgde	740	37	macrophages	macrophage	NNS
cord-336510-qzm9wgde	740	38	Mechanisms	mechanism	NNS
cord-336510-qzm9wgde	740	39	of	of	IN
cord-336510-qzm9wgde	740	40	suppression	suppression	NN
cord-336510-qzm9wgde	740	41	of	of	IN
cord-336510-qzm9wgde	740	42	macrophage	macrophage	NN
cord-336510-qzm9wgde	740	43	nitric	nitric	NN
cord-336510-qzm9wgde	740	44	oxide	oxide	NN
cord-336510-qzm9wgde	740	45	release	release	NN
cord-336510-qzm9wgde	740	46	by	by	IN
cord-336510-qzm9wgde	740	47	transforming	transform	VBG
cord-336510-qzm9wgde	740	48	growth	growth	NN
cord-336510-qzm9wgde	740	49	factor	factor	NN
cord-336510-qzm9wgde	740	50	beta	beta	NN
cord-336510-qzm9wgde	740	51	Spontaneously	spontaneously	RB
cord-336510-qzm9wgde	740	52	increased	increase	VBD
cord-336510-qzm9wgde	740	53	production	production	NN
cord-336510-qzm9wgde	740	54	of	of	IN
cord-336510-qzm9wgde	740	55	nitric	nitric	NN
cord-336510-qzm9wgde	740	56	oxide	oxide	NN
cord-336510-qzm9wgde	740	57	and	and	CC
cord-336510-qzm9wgde	740	58	aberrant	aberrant	JJ
cord-336510-qzm9wgde	740	59	expression	expression	NN
cord-336510-qzm9wgde	740	60	of	of	IN
cord-336510-qzm9wgde	740	61	the	the	DT
cord-336510-qzm9wgde	740	62	inducible	inducible	JJ
cord-336510-qzm9wgde	740	63	nitric	nitric	NN
cord-336510-qzm9wgde	740	64	oxide	oxide	NN
cord-336510-qzm9wgde	740	65	synthase	synthase	NN
cord-336510-qzm9wgde	740	66	in	in	IN
cord-336510-qzm9wgde	740	67	vivo	vivo	NN
cord-336510-qzm9wgde	740	68	in	in	IN
cord-336510-qzm9wgde	740	69	the	the	DT
cord-336510-qzm9wgde	740	70	transforming	transform	VBG
cord-336510-qzm9wgde	740	71	growth	growth	NN
cord-336510-qzm9wgde	740	72	factor	factor	NN
cord-336510-qzm9wgde	740	73	beta	beta	NN
cord-336510-qzm9wgde	740	74	1	1	CD
cord-336510-qzm9wgde	740	75	null	null	NN
cord-336510-qzm9wgde	740	76	mouse	mouse	NN
cord-336510-qzm9wgde	740	77	Effect	effect	NN
cord-336510-qzm9wgde	740	78	of	of	IN
cord-336510-qzm9wgde	740	79	the	the	DT
cord-336510-qzm9wgde	740	80	deletion	deletion	NN
cord-336510-qzm9wgde	740	81	of	of	IN
cord-336510-qzm9wgde	740	82	US2	US2	NNP
cord-336510-qzm9wgde	740	83	and	and	CC
cord-336510-qzm9wgde	740	84	US3	US3	NNP
cord-336510-qzm9wgde	740	85	from	from	IN
cord-336510-qzm9wgde	740	86	herpes	herpes	NNP
cord-336510-qzm9wgde	740	87	simplex	simplex	NNP
cord-336510-qzm9wgde	740	88	virus	virus	NN
cord-336510-qzm9wgde	740	89	type	type	NN
cord-336510-qzm9wgde	740	90	2	2	CD
cord-336510-qzm9wgde	740	91	on	on	IN
cord-336510-qzm9wgde	740	92	immune	immune	JJ
cord-336510-qzm9wgde	740	93	responses	response	NNS
cord-336510-qzm9wgde	740	94	in	in	IN
cord-336510-qzm9wgde	740	95	the	the	DT
cord-336510-qzm9wgde	740	96	murine	murine	JJ
cord-336510-qzm9wgde	740	97	vagina	vagina	NN
cord-336510-qzm9wgde	740	98	following	follow	VBG
cord-336510-qzm9wgde	740	99	intravaginal	intravaginal	JJ
cord-336510-qzm9wgde	740	100	infection	infection	NN
cord-336510-qzm9wgde	741	1	Small	small	JJ
cord-336510-qzm9wgde	741	2	amounts	amount	NNS
cord-336510-qzm9wgde	741	3	of	of	IN
cord-336510-qzm9wgde	741	4	exogenous	exogenous	JJ
cord-336510-qzm9wgde	741	5	IL-4	IL-4	NNP
cord-336510-qzm9wgde	741	6	increase	increase	VB
cord-336510-qzm9wgde	741	7	the	the	DT
cord-336510-qzm9wgde	741	8	severity	severity	NN
cord-336510-qzm9wgde	741	9	of	of	IN
cord-336510-qzm9wgde	741	10	encephalitis	encephalitis	RB
cord-336510-qzm9wgde	741	11	induced	induce	VBN
cord-336510-qzm9wgde	741	12	in	in	IN
cord-336510-qzm9wgde	741	13	mice	mouse	NNS
cord-336510-qzm9wgde	741	14	by	by	IN
cord-336510-qzm9wgde	741	15	the	the	DT
cord-336510-qzm9wgde	741	16	intranasal	intranasal	NN
cord-336510-qzm9wgde	741	17	infection	infection	NN
cord-336510-qzm9wgde	741	18	of	of	IN
cord-336510-qzm9wgde	741	19	herpes	herpes	NNP
cord-336510-qzm9wgde	741	20	simplex	simplex	NNP
cord-336510-qzm9wgde	741	21	virus	virus	NN
cord-336510-qzm9wgde	741	22	type	type	NN
cord-336510-qzm9wgde	741	23	1	1	CD
cord-336510-qzm9wgde	741	24	Herpes	Herpes	NNP
cord-336510-qzm9wgde	741	25	simplex	simplex	NN
cord-336510-qzm9wgde	741	26	virus	virus	NN
cord-336510-qzm9wgde	741	27	type	type	NN
cord-336510-qzm9wgde	741	28	2	2	CD
cord-336510-qzm9wgde	741	29	infection	infection	NN
cord-336510-qzm9wgde	741	30	of	of	IN
cord-336510-qzm9wgde	741	31	macrophages	macrophage	NNS
cord-336510-qzm9wgde	741	32	impairs	impair	VBZ
cord-336510-qzm9wgde	741	33	IL-4-mediated	il-4-mediated	CD
cord-336510-qzm9wgde	741	34	inhibition	inhibition	NN
cord-336510-qzm9wgde	741	35	of	of	IN
cord-336510-qzm9wgde	741	36	NO	no	DT
cord-336510-qzm9wgde	741	37	production	production	NN
cord-336510-qzm9wgde	741	38	through	through	IN
cord-336510-qzm9wgde	741	39	TNFalpha	tnfalpha	NN
cord-336510-qzm9wgde	741	40	-	-	HYPH
cord-336510-qzm9wgde	741	41	induced	induce	VBN
cord-336510-qzm9wgde	741	42	activation	activation	NN
cord-336510-qzm9wgde	741	43	of	of	IN
cord-336510-qzm9wgde	741	44	NF	NF	NNP
cord-336510-qzm9wgde	741	45	-	-	HYPH
cord-336510-qzm9wgde	741	46	kappaB	kappaB	NNP
cord-336510-qzm9wgde	741	47	IL-4-induced	il-4-induce	VBN
cord-336510-qzm9wgde	742	1	STAT6	STAT6	NNP
cord-336510-qzm9wgde	742	2	suppresses	suppress	VBZ
cord-336510-qzm9wgde	742	3	IFNgamma	IFNgamma	NNP
cord-336510-qzm9wgde	742	4	-	-	HYPH
cord-336510-qzm9wgde	742	5	stimulated	stimulate	VBN
cord-336510-qzm9wgde	742	6	STAT1-dependent	STAT1-dependent	NNP
cord-336510-qzm9wgde	742	7	transcription	transcription	NN
cord-336510-qzm9wgde	742	8	in	in	IN
cord-336510-qzm9wgde	742	9	mouse	mouse	NN
cord-336510-qzm9wgde	742	10	macrophages	macrophage	NNS
cord-336510-qzm9wgde	743	1	Impaired	impaired	JJ
cord-336510-qzm9wgde	743	2	IL-13-mediated	il-13-mediated	JJ
cord-336510-qzm9wgde	743	3	functions	function	NNS
cord-336510-qzm9wgde	743	4	of	of	IN
cord-336510-qzm9wgde	743	5	macrophages	macrophage	NNS
cord-336510-qzm9wgde	743	6	in	in	IN
cord-336510-qzm9wgde	743	7	STAT6-deficient	stat6-deficient	CD
cord-336510-qzm9wgde	743	8	mice	mouse	NNS
cord-336510-qzm9wgde	743	9	Structure	structure	NN
cord-336510-qzm9wgde	743	10	and	and	CC
cord-336510-qzm9wgde	743	11	regulation	regulation	NN
cord-336510-qzm9wgde	743	12	of	of	IN
cord-336510-qzm9wgde	743	13	the	the	DT
cord-336510-qzm9wgde	743	14	human	human	JJ
cord-336510-qzm9wgde	743	15	interferon	interferon	NN
cord-336510-qzm9wgde	743	16	regulatory	regulatory	JJ
cord-336510-qzm9wgde	743	17	factor	factor	NN
cord-336510-qzm9wgde	743	18	1	1	CD
cord-336510-qzm9wgde	743	19	(	(	-LRB-
cord-336510-qzm9wgde	743	20	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	743	21	)	)	-RRB-
cord-336510-qzm9wgde	743	22	and	and	CC
cord-336510-qzm9wgde	743	23	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	743	24	genes	gene	NNS
cord-336510-qzm9wgde	743	25	:	:	:
cord-336510-qzm9wgde	743	26	implications	implication	NNS
cord-336510-qzm9wgde	743	27	for	for	IN
cord-336510-qzm9wgde	743	28	a	a	DT
cord-336510-qzm9wgde	743	29	gene	gene	NN
cord-336510-qzm9wgde	743	30	network	network	NN
cord-336510-qzm9wgde	743	31	in	in	IN
cord-336510-qzm9wgde	743	32	the	the	DT
cord-336510-qzm9wgde	743	33	interferon	interferon	NN
cord-336510-qzm9wgde	743	34	system	system	NN
cord-336510-qzm9wgde	743	35	Structurally	structurally	RB
cord-336510-qzm9wgde	743	36	similar	similar	JJ
cord-336510-qzm9wgde	743	37	but	but	CC
cord-336510-qzm9wgde	743	38	functionally	functionally	RB
cord-336510-qzm9wgde	743	39	distinct	distinct	JJ
cord-336510-qzm9wgde	743	40	factors	factor	NNS
cord-336510-qzm9wgde	743	41	,	,	,
cord-336510-qzm9wgde	743	42	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	743	43	and	and	CC
cord-336510-qzm9wgde	743	44	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	743	45	,	,	,
cord-336510-qzm9wgde	743	46	bind	bind	VB
cord-336510-qzm9wgde	743	47	to	to	IN
cord-336510-qzm9wgde	743	48	the	the	DT
cord-336510-qzm9wgde	743	49	same	same	JJ
cord-336510-qzm9wgde	743	50	regulatory	regulatory	JJ
cord-336510-qzm9wgde	743	51	elements	element	NNS
cord-336510-qzm9wgde	743	52	of	of	IN
cord-336510-qzm9wgde	743	53	IFN	IFN	NNP
cord-336510-qzm9wgde	743	54	and	and	CC
cord-336510-qzm9wgde	743	55	IFN	IFN	NNP
cord-336510-qzm9wgde	743	56	-	-	HYPH
cord-336510-qzm9wgde	743	57	inducible	inducible	JJ
cord-336510-qzm9wgde	743	58	genes	gene	NNS
cord-336510-qzm9wgde	744	1	Absence	absence	NN
cord-336510-qzm9wgde	744	2	of	of	IN
cord-336510-qzm9wgde	744	3	the	the	DT
cord-336510-qzm9wgde	744	4	type	type	NN
cord-336510-qzm9wgde	745	1	I	-PRON-	PRP
cord-336510-qzm9wgde	745	2	IFN	IFN	NNP
cord-336510-qzm9wgde	745	3	system	system	NN
cord-336510-qzm9wgde	745	4	in	in	IN
cord-336510-qzm9wgde	745	5	EC	EC	NNP
cord-336510-qzm9wgde	745	6	cells	cell	NNS
cord-336510-qzm9wgde	745	7	:	:	:
cord-336510-qzm9wgde	745	8	transcriptional	transcriptional	JJ
cord-336510-qzm9wgde	745	9	activator	activator	NN
cord-336510-qzm9wgde	745	10	(	(	-LRB-
cord-336510-qzm9wgde	745	11	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	745	12	)	)	-RRB-
cord-336510-qzm9wgde	745	13	and	and	CC
cord-336510-qzm9wgde	745	14	repressor	repressor	NN
cord-336510-qzm9wgde	745	15	(	(	-LRB-
cord-336510-qzm9wgde	745	16	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	745	17	)	)	-RRB-
cord-336510-qzm9wgde	745	18	genes	gene	NNS
cord-336510-qzm9wgde	745	19	are	be	VBP
cord-336510-qzm9wgde	745	20	developmentally	developmentally	RB
cord-336510-qzm9wgde	745	21	regulated	regulate	VBN
cord-336510-qzm9wgde	745	22	Recognition	recognition	NN
cord-336510-qzm9wgde	745	23	DNA	dna	NN
cord-336510-qzm9wgde	745	24	sequences	sequence	NNS
cord-336510-qzm9wgde	745	25	of	of	IN
cord-336510-qzm9wgde	745	26	interferon	interferon	NN
cord-336510-qzm9wgde	745	27	regulatory	regulatory	JJ
cord-336510-qzm9wgde	745	28	factor	factor	NN
cord-336510-qzm9wgde	745	29	1	1	CD
cord-336510-qzm9wgde	745	30	(	(	-LRB-
cord-336510-qzm9wgde	745	31	IRF-1	IRF-1	NNP
cord-336510-qzm9wgde	745	32	)	)	-RRB-
cord-336510-qzm9wgde	745	33	and	and	CC
cord-336510-qzm9wgde	745	34	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	745	35	,	,	,
cord-336510-qzm9wgde	745	36	regulators	regulator	NNS
cord-336510-qzm9wgde	745	37	of	of	IN
cord-336510-qzm9wgde	745	38	cell	cell	NN
cord-336510-qzm9wgde	745	39	growth	growth	NN
cord-336510-qzm9wgde	745	40	and	and	CC
cord-336510-qzm9wgde	745	41	the	the	DT
cord-336510-qzm9wgde	745	42	interferon	interferon	NN
cord-336510-qzm9wgde	745	43	system	system	NN
cord-336510-qzm9wgde	745	44	B	B	NNP
cord-336510-qzm9wgde	745	45	lymphocyte	lymphocyte	NN
cord-336510-qzm9wgde	745	46	-	-	HYPH
cord-336510-qzm9wgde	745	47	induced	induce	VBN
cord-336510-qzm9wgde	745	48	maturation	maturation	NN
cord-336510-qzm9wgde	745	49	protein	protein	NN
cord-336510-qzm9wgde	745	50	(	(	-LRB-
cord-336510-qzm9wgde	745	51	Blimp)-1	Blimp)-1	NNP
cord-336510-qzm9wgde	745	52	,	,	,
cord-336510-qzm9wgde	745	53	IFN	IFN	NNP
cord-336510-qzm9wgde	745	54	regulatory	regulatory	JJ
cord-336510-qzm9wgde	745	55	factor	factor	NN
cord-336510-qzm9wgde	745	56	(	(	-LRB-
cord-336510-qzm9wgde	745	57	IRF)-1	IRF)-1	NNP
cord-336510-qzm9wgde	745	58	,	,	,
cord-336510-qzm9wgde	745	59	and	and	CC
cord-336510-qzm9wgde	745	60	IRF-2	IRF-2	NNP
cord-336510-qzm9wgde	745	61	can	can	MD
cord-336510-qzm9wgde	745	62	bind	bind	VB
cord-336510-qzm9wgde	745	63	to	to	IN
cord-336510-qzm9wgde	745	64	the	the	DT
cord-336510-qzm9wgde	745	65	same	same	JJ
cord-336510-qzm9wgde	745	66	regulatory	regulatory	JJ
cord-336510-qzm9wgde	745	67	sites	site	NNS
cord-336510-qzm9wgde	745	68	Inhibition	inhibition	NN
cord-336510-qzm9wgde	745	69	of	of	IN
cord-336510-qzm9wgde	745	70	NO	no	DT
cord-336510-qzm9wgde	745	71	production	production	NN
cord-336510-qzm9wgde	745	72	in	in	IN
cord-336510-qzm9wgde	745	73	macrophages	macrophage	NNS
cord-336510-qzm9wgde	745	74	by	by	IN
cord-336510-qzm9wgde	745	75	IL-13	IL-13	NNP
cord-336510-qzm9wgde	745	76	is	be	VBZ
cord-336510-qzm9wgde	745	77	counteracted	counteract	VBN
cord-336510-qzm9wgde	745	78	by	by	IN
cord-336510-qzm9wgde	745	79	Herpes	Herpes	NNP
cord-336510-qzm9wgde	745	80	simplex	simplex	NN
cord-336510-qzm9wgde	745	81	virus	virus	NN
cord-336510-qzm9wgde	745	82	infection	infection	NN
cord-336510-qzm9wgde	745	83	through	through	IN
cord-336510-qzm9wgde	745	84	tumor	tumor	NN
cord-336510-qzm9wgde	745	85	necrosis	necrosis	NN
cord-336510-qzm9wgde	745	86	factor	factor	NN
cord-336510-qzm9wgde	745	87	-	-	HYPH
cord-336510-qzm9wgde	745	88	alpha	alpha	NN
cord-336510-qzm9wgde	745	89	-	-	HYPH
cord-336510-qzm9wgde	745	90	induced	induce	VBN
cord-336510-qzm9wgde	745	91	activation	activation	NN
cord-336510-qzm9wgde	745	92	of	of	IN
cord-336510-qzm9wgde	745	93	NK	NK	NNP
cord-336510-qzm9wgde	745	94	-	-	HYPH
cord-336510-qzm9wgde	745	95	kappa	kappa	NN
cord-336510-qzm9wgde	745	96	B	B	NNP
cord-336510-qzm9wgde	745	97	Interleukin-4	Interleukin-4	NNP
cord-336510-qzm9wgde	745	98	and	and	CC
cord-336510-qzm9wgde	745	99	interleukin-10	interleukin-10	NN
cord-336510-qzm9wgde	745	100	modulate	modulate	VB
cord-336510-qzm9wgde	745	101	nuclear	nuclear	JJ
cord-336510-qzm9wgde	745	102	factor	factor	NN
cord-336510-qzm9wgde	745	103	kappaB	kappaB	NNP
cord-336510-qzm9wgde	745	104	activity	activity	NN
cord-336510-qzm9wgde	745	105	and	and	CC
cord-336510-qzm9wgde	745	106	nitric	nitric	NN
cord-336510-qzm9wgde	745	107	oxide	oxide	NN
cord-336510-qzm9wgde	745	108	synthase-2	synthase-2	NNP
cord-336510-qzm9wgde	745	109	expression	expression	NN
cord-336510-qzm9wgde	745	110	in	in	IN
cord-336510-qzm9wgde	745	111	Theiler	Theiler	NNP
cord-336510-qzm9wgde	745	112	's	's	POS
cord-336510-qzm9wgde	745	113	virus	virus	NN
cord-336510-qzm9wgde	745	114	-	-	HYPH
cord-336510-qzm9wgde	745	115	infected	infect	VBN
cord-336510-qzm9wgde	745	116	brain	brain	NN
cord-336510-qzm9wgde	745	117	astrocytes	astrocyte	VBZ
cord-336510-qzm9wgde	745	118	Interaction	Interaction	NNP
cord-336510-qzm9wgde	745	119	of	of	IN
cord-336510-qzm9wgde	745	120	interferon	interferon	NN
cord-336510-qzm9wgde	745	121	regulatory	regulatory	JJ
cord-336510-qzm9wgde	745	122	factor-1	factor-1	NNP
cord-336510-qzm9wgde	745	123	and	and	CC
cord-336510-qzm9wgde	745	124	nuclear	nuclear	JJ
cord-336510-qzm9wgde	745	125	factor	factor	NN
cord-336510-qzm9wgde	745	126	kap	kap	NN
cord-336510-qzm9wgde	745	127	-	-	HYPH
cord-336510-qzm9wgde	745	128	paB	paB	NNP
cord-336510-qzm9wgde	745	129	during	during	IN
cord-336510-qzm9wgde	745	130	activation	activation	NN
cord-336510-qzm9wgde	745	131	of	of	IN
cord-336510-qzm9wgde	745	132	inducible	inducible	JJ
cord-336510-qzm9wgde	745	133	nitric	nitric	NN
cord-336510-qzm9wgde	745	134	oxide	oxide	NN
cord-336510-qzm9wgde	745	135	synthase	synthase	NN
cord-336510-qzm9wgde	745	136	transcription	transcription	NN
cord-336510-qzm9wgde	746	1	I	-PRON-	PRP
cord-336510-qzm9wgde	746	2	wish	wish	VBP
cord-336510-qzm9wgde	746	3	to	to	TO
cord-336510-qzm9wgde	746	4	thank	thank	VB
cord-336510-qzm9wgde	746	5	all	all	DT
cord-336510-qzm9wgde	746	6	members	member	NNS
cord-336510-qzm9wgde	746	7	of	of	IN
cord-336510-qzm9wgde	746	8	the	the	DT
cord-336510-qzm9wgde	746	9	group	group	NN
cord-336510-qzm9wgde	746	10	for	for	IN
cord-336510-qzm9wgde	746	11	highly	highly	RB
cord-336510-qzm9wgde	746	12	constructive	constructive	JJ
cord-336510-qzm9wgde	746	13	discussions	discussion	NNS
cord-336510-qzm9wgde	746	14	and	and	CC
cord-336510-qzm9wgde	746	15	especially	especially	RB
cord-336510-qzm9wgde	746	16	Søren	Søren	NNP
cord-336510-qzm9wgde	746	17	C.	C.	NNP
cord-336510-qzm9wgde	746	18	Mogensen	Mogensen	NNP
cord-336510-qzm9wgde	746	19	for	for	IN
cord-336510-qzm9wgde	746	20	critical	critical	JJ
cord-336510-qzm9wgde	746	21	review	review	NN
cord-336510-qzm9wgde	746	22	of	of	IN
cord-336510-qzm9wgde	746	23	the	the	DT
cord-336510-qzm9wgde	746	24	manuscript	manuscript	NN
cord-336510-qzm9wgde	746	25	.	.	.
cord-336510-qzm9wgde	747	1	For	for	IN
cord-336510-qzm9wgde	747	2	excellent	excellent	JJ
cord-336510-qzm9wgde	747	3	technical	technical	JJ
cord-336510-qzm9wgde	747	4	help	help	NN
cord-336510-qzm9wgde	747	5	with	with	IN
cord-336510-qzm9wgde	747	6	the	the	DT
cord-336510-qzm9wgde	747	7	electron	electron	NN
cord-336510-qzm9wgde	747	8	microscopy	microscopy	NN
cord-336510-qzm9wgde	747	9	I	-PRON-	PRP
cord-336510-qzm9wgde	747	10	thank	thank	VBP
cord-336510-qzm9wgde	747	11	Ruth	Ruth	NNP
cord-336510-qzm9wgde	747	12	Nielsen	Nielsen	NNP
cord-336510-qzm9wgde	747	13	.	.	.
cord-336510-qzm9wgde	748	1	Furthermore	furthermore	RB
cord-336510-qzm9wgde	748	2	,	,	,
cord-336510-qzm9wgde	748	3	I	-PRON-	PRP
cord-336510-qzm9wgde	748	4	wish	wish	VBP
cord-336510-qzm9wgde	748	5	to	to	TO
cord-336510-qzm9wgde	748	6	thank	thank	VB
cord-336510-qzm9wgde	748	7	The	the	DT
cord-336510-qzm9wgde	748	8	Department	Department	NNP
cord-336510-qzm9wgde	748	9	of	of	IN
cord-336510-qzm9wgde	748	10	Clinical	Clinical	NNP
cord-336510-qzm9wgde	748	11	Microbiology	Microbiology	NNP
cord-336510-qzm9wgde	748	12	,	,	,
cord-336510-qzm9wgde	748	13	Aarhus	Aarhus	NNP
cord-336510-qzm9wgde	748	14	University	University	NNP
cord-336510-qzm9wgde	748	15	Hospital	Hospital	NNP
cord-336510-qzm9wgde	748	16	,	,	,
cord-336510-qzm9wgde	748	17	Skejby	Skejby	NNP
cord-336510-qzm9wgde	748	18	and	and	CC
cord-336510-qzm9wgde	748	19	Department	Department	NNP
cord-336510-qzm9wgde	748	20	of	of	IN
cord-336510-qzm9wgde	748	21	Medical	Medical	NNP
cord-336510-qzm9wgde	748	22	Microbiology	Microbiology	NNP
cord-336510-qzm9wgde	748	23	and	and	CC
cord-336510-qzm9wgde	748	24	Immunology	Immunology	NNP
cord-336510-qzm9wgde	748	25	,	,	,
cord-336510-qzm9wgde	748	26	University	University	NNP
cord-336510-qzm9wgde	748	27	of	of	IN
cord-336510-qzm9wgde	748	28	Aarhus	Aarhus	NNP
cord-336510-qzm9wgde	748	29	for	for	IN
cord-336510-qzm9wgde	748	30	their	-PRON-	PRP$
cord-336510-qzm9wgde	748	31	hospitality	hospitality	NN
cord-336510-qzm9wgde	748	32	and	and	CC
cord-336510-qzm9wgde	748	33	support	support	NN
cord-336510-qzm9wgde	748	34	.	.	.