id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016283-b6yywn9f	Hasan, Ashfaq	Clinical Aspects and Principles of Management of Tuberculosis	2019-08-07		.txt	text/plain	6930	347	46	Notwithstanding the advances in modern science, clinical diagnosis sometimes remains elusive, owing principally to the frequent paucibacillary occurrence of the disease and the slow doubling time of the organism; empiric treatment is often fraught with risks in the era of increasing drug resistance. The line probe assays (LPA) can permit rapid identification of specific gene markers associated with rifampicin resistance alone or in combination with isoniazid, and provide clinically relevant information about the level of INH resistance (low level associated with the INH-A gene; versus high level associated with the kat-G gene) (WHO treatment guidance for drug resistant tuberculosis 2016). Anti-tubercular drugs require to be supplemented with carefully monitored steroid therapy in two circumstances: tubercular meningitis (a short course of dexamethasone or prednisolone is typically given, tapered over 6 to 8 weeks) and tuberculous pericarditis (Guidelines for treatment of drug-susceptible tuberculosis and patient care 2017).	./cache/cord-016283-b6yywn9f.txt	./txt/cord-016283-b6yywn9f.txt