id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016290-l592k753	Finke, Jürgen	Hematology and Hemostasis	2008		.txt	text/plain	11717	1308	39	In patients previously exposed to heparin (< 100 days), reoccurrence within hours • Severe thrombocytopenia (platelets < 100,000/µl), median platelet count approximately 60,000/µl, rarely < 20,000/µl or decreased to < 50% of the initial count; worsening of thrombocytopenia if heparin treatment is continued • Thromboembolic complications up to 40 days after heparin administration • IgG antibodies mostly against the platelet factor 4 (PF4)-heparin complex → Immune complex formation → Platelet activation due to binding of the immune complex to the Fc receptor (Fcγ RIIA), PF4 release → Platelet aggregation, endothelial cell damage, thrombin activation → Thromboembolic complications ("white clot syndrome") Clinical relevance: HIT type II: • Main symptom: thrombophilia, not hemorrhage • Warning signs: exanthema or necrosis at injection site • High incidence (up to 53%) of venous and arterial thrombosis, renal dysfunction, pulmonary embolism, infarction (complications may occur weeks after discontinuation of heparin)	./cache/cord-016290-l592k753.txt	./txt/cord-016290-l592k753.txt