id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018620-3kqx8arn	Rueda, Mario	Hepatic Failure	2016-10-09		.txt	text/plain	13808	842	44	In this chapter we will discuss the definition, clinical manifestations, workup, and management of acute and chronic liver failure and the general principles of treatment of these patients. Other mechanisms that may explain this symptom include the endogenous opioids theory which proposes that the liver failure patient has elevated opioid levels secondary to decrease clearance and metabolism. Past medical history plays a key role in determining if the patient has chronic liver disease or if they are experiencing an acute failure. A decrease in glutathione levels, enhanced cytochrome P450 activity secondary to medication use, acetaminophen overdose, or decreased liver function from chronic disease make patients more susceptible to developing toxicity. Patients with hepatitis secondary to shock present with several symptoms related to their hemodynamic instability including altered mental status, respiratory distress, severe hypotension, and renal failure.	./cache/cord-018620-3kqx8arn.txt	./txt/cord-018620-3kqx8arn.txt