id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308169-a0ft6wdy	Custovic, A.	EAACI position statement on asthma exacerbations and severe asthma	2013-11-06		.txt	text/plain	7710	379	41	A recently published consensus statement on severe asthma broadened the concept of 'difficult asthma' to reflect the situation in less developed countries, where access to medications and appropriate care is a major issue, by defining three different patient groups including un(der)treated symptomatic patients, patients with low treatment adherence or unconventional therapies, and those remaining symptomatic despite high doses of anti-asthmatic therapies (13, 14) . Other similar initiatives included the EU-sponsored Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) consortium that has published a consensus-based systematic algorithm approach to differentiate between 'problematic', 'difficult' and 'severe refractory' asthma in the evaluation of patients with chronic severe asthma symptoms for use in clinical research and specialized care (73) . These treatment options for patients with severe asthma who remain symptomatic despite adhering to standard medical care include novel anti-inflammatory drugs that have been shown in preliminary studies to be effective in treating airway inflammation in asthma and so warrant further investigation (32, (83) (84) (85) (86) , and other novel approaches such as bronchial thermoplasty (87) .	./cache/cord-308169-a0ft6wdy.txt	./txt/cord-308169-a0ft6wdy.txt