id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316117-o29773cz	Menzella, Francesco	Pharmacologicaltreatment of COVID-19: lights and shadows	2020-05-19		.txt	text/plain	4459	265	45	At the end of December 2019, a novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China and then the entire world, forcing the World Health Organization (WHO) to make the assessment that the coronavirus disease (COVID19) can be characterized as a pandemic, the first ever caused by a coronavirus. The search strategy was based on the following keywords: coronavirus, SARS-CoV-2 pneumonia, COVID-19, severe acute respiratory syndrome, antivirals, corticosteroids, biologics, and anticoagulants. Current antiviral treatments are mainly based on previous experiences (favipiravir) or on experimental drugs (remdesivir) used for the treatment of viral infections due to different viruses, such as influenza virus (InfV), Ebolavirus (EBOV), human immunodeficiency virus (HIV), MERS, and SARS. 38 On the contrary, in a study with a small cohort of patients hospitalized for severe SARS-CoV-2 infection, no strong antiviral activity or clinical efficacy of the combination of hydroxychloroquine and azithromycin was found.	./cache/cord-316117-o29773cz.txt	./txt/cord-316117-o29773cz.txt