id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349990-i3jslrae	Visca, Dina	Management of chronic refractory cough in adults	2020-09-19		.txt	text/plain	5979	284	42	Current international guidelines provide algorithms for the management of chronic cough: in most cases, treatment of the underlying disease is sufficient to improve or resolve cough symptoms. Under pathological conditions of known and unknown etiologies, chronic refractory cough (CRC) may become a major medical problem because patients may need to undergo repeated examinations before reaching a diagnosis, and/or try several treatments with sometimes poor symptom control, worsening their quality of life and increasing economic burden. conducted a multicenter randomized controlled trial in 75 patients with CRC, and observed an improvement in cough-specific quality of life (Leicester Cough Questionnaire) and cough frequency (Leicester Cough Monitor) as a consequence of implementing a combined physiotherapy and speech and language therapy intervention [19] . investigated the potential effects of azithromycin on chronic cough in a randomized, double-blind, placebo-controlled study [61] . MK-7264, a P2×3 receptor antagonist, reduces cough frequency in patients with refractory chronic cough: results from a randomized, controlled, Phase 2b clinical trial	./cache/cord-349990-i3jslrae.txt	./txt/cord-349990-i3jslrae.txt