id sid tid token lemma pos cord-302215-sqrbj5r4 1 1 key key NN cord-302215-sqrbj5r4 1 2 : : : cord-302215-sqrbj5r4 2 1 cord-302215-sqrbj5r4 cord-302215-sqrbj5r4 NNP cord-302215-sqrbj5r4 2 2 authors author NNS cord-302215-sqrbj5r4 2 3 : : : cord-302215-sqrbj5r4 2 4 Vanden Vanden NNP cord-302215-sqrbj5r4 2 5 Eynde Eynde NNP cord-302215-sqrbj5r4 2 6 , , , cord-302215-sqrbj5r4 2 7 Jean Jean NNP cord-302215-sqrbj5r4 2 8 Jacques Jacques NNP cord-302215-sqrbj5r4 2 9 title title NN cord-302215-sqrbj5r4 2 10 : : : cord-302215-sqrbj5r4 3 1 COVID-19 covid-19 VB cord-302215-sqrbj5r4 3 2 : : : cord-302215-sqrbj5r4 4 1 An an DT cord-302215-sqrbj5r4 4 2 Update update NN cord-302215-sqrbj5r4 4 3 about about IN cord-302215-sqrbj5r4 4 4 the the DT cord-302215-sqrbj5r4 4 5 Discovery Discovery NNP cord-302215-sqrbj5r4 4 6 Clinical Clinical NNP cord-302215-sqrbj5r4 4 7 Trial Trial NNP cord-302215-sqrbj5r4 4 8 date date NN cord-302215-sqrbj5r4 4 9 : : : cord-302215-sqrbj5r4 4 10 2020 2020 CD cord-302215-sqrbj5r4 4 11 - - HYPH cord-302215-sqrbj5r4 4 12 05 05 CD cord-302215-sqrbj5r4 4 13 - - SYM cord-302215-sqrbj5r4 4 14 14 14 CD cord-302215-sqrbj5r4 4 15 journal journal NN cord-302215-sqrbj5r4 4 16 : : : cord-302215-sqrbj5r4 4 17 Pharmaceuticals Pharmaceuticals NNP cord-302215-sqrbj5r4 4 18 ( ( -LRB- cord-302215-sqrbj5r4 4 19 Basel Basel NNP cord-302215-sqrbj5r4 4 20 ) ) -RRB- cord-302215-sqrbj5r4 4 21 DOI DOI NNP cord-302215-sqrbj5r4 4 22 : : : cord-302215-sqrbj5r4 4 23 10.3390 10.3390 CD cord-302215-sqrbj5r4 4 24 / / SYM cord-302215-sqrbj5r4 4 25 ph13050098 ph13050098 NN cord-302215-sqrbj5r4 4 26 sha sha NN cord-302215-sqrbj5r4 4 27 : : : cord-302215-sqrbj5r4 4 28 980f2cc5ac25e91562b9117adf9685e275149fff 980f2cc5ac25e91562b9117adf9685e275149fff CD cord-302215-sqrbj5r4 4 29 doc_id doc_id CD cord-302215-sqrbj5r4 4 30 : : : cord-302215-sqrbj5r4 4 31 302215 302215 CD cord-302215-sqrbj5r4 4 32 cord_uid cord_uid NNS cord-302215-sqrbj5r4 4 33 : : : cord-302215-sqrbj5r4 5 1 sqrbj5r4 sqrbj5r4 DT cord-302215-sqrbj5r4 5 2 Finding find VBG cord-302215-sqrbj5r4 5 3 efficacious efficacious JJ cord-302215-sqrbj5r4 5 4 and and CC cord-302215-sqrbj5r4 5 5 safe safe JJ cord-302215-sqrbj5r4 5 6 treatments treatment NNS cord-302215-sqrbj5r4 5 7 for for IN cord-302215-sqrbj5r4 5 8 COVID-19 covid-19 NN cord-302215-sqrbj5r4 5 9 emerges emerge VBZ cord-302215-sqrbj5r4 5 10 as as IN cord-302215-sqrbj5r4 5 11 a a DT cord-302215-sqrbj5r4 5 12 crucial crucial JJ cord-302215-sqrbj5r4 5 13 need need NN cord-302215-sqrbj5r4 5 14 in in IN cord-302215-sqrbj5r4 5 15 order order NN cord-302215-sqrbj5r4 5 16 to to TO cord-302215-sqrbj5r4 5 17 control control VB cord-302215-sqrbj5r4 5 18 the the DT cord-302215-sqrbj5r4 5 19 spread spread NN cord-302215-sqrbj5r4 5 20 of of IN cord-302215-sqrbj5r4 5 21 the the DT cord-302215-sqrbj5r4 5 22 pandemic pandemic NN cord-302215-sqrbj5r4 5 23 . . . cord-302215-sqrbj5r4 6 1 Whereas whereas IN cord-302215-sqrbj5r4 6 2 plasma plasma NN cord-302215-sqrbj5r4 6 3 therapy therapy NN cord-302215-sqrbj5r4 6 4 attracts attract VBZ cord-302215-sqrbj5r4 6 5 much much JJ cord-302215-sqrbj5r4 6 6 interest interest NN cord-302215-sqrbj5r4 6 7 , , , cord-302215-sqrbj5r4 6 8 the the DT cord-302215-sqrbj5r4 6 9 European european JJ cord-302215-sqrbj5r4 6 10 project project NN cord-302215-sqrbj5r4 6 11 Discovery Discovery NNP cord-302215-sqrbj5r4 6 12 focuses focus VBZ cord-302215-sqrbj5r4 6 13 on on IN cord-302215-sqrbj5r4 6 14 the the DT cord-302215-sqrbj5r4 6 15 potentialities potentiality NNS cord-302215-sqrbj5r4 6 16 of of IN cord-302215-sqrbj5r4 6 17 small small JJ cord-302215-sqrbj5r4 6 18 molecules molecule NNS cord-302215-sqrbj5r4 6 19 like like IN cord-302215-sqrbj5r4 6 20 remdesivir remdesivir NNP cord-302215-sqrbj5r4 6 21 , , , cord-302215-sqrbj5r4 6 22 the the DT cord-302215-sqrbj5r4 6 23 combination combination NN cord-302215-sqrbj5r4 6 24 of of IN cord-302215-sqrbj5r4 6 25 lopinavir lopinavir NNS cord-302215-sqrbj5r4 6 26 / / SYM cord-302215-sqrbj5r4 6 27 ritonavir ritonavir NNP cord-302215-sqrbj5r4 6 28 , , , cord-302215-sqrbj5r4 6 29 hydroxychloroquine hydroxychloroquine NNP cord-302215-sqrbj5r4 6 30 , , , cord-302215-sqrbj5r4 6 31 and and CC cord-302215-sqrbj5r4 6 32 chloroquine chloroquine NN cord-302215-sqrbj5r4 6 33 . . . cord-302215-sqrbj5r4 7 1 Results result NNS cord-302215-sqrbj5r4 7 2 recently recently RB cord-302215-sqrbj5r4 7 3 published publish VBN cord-302215-sqrbj5r4 7 4 on on IN cord-302215-sqrbj5r4 7 5 the the DT cord-302215-sqrbj5r4 7 6 clinical clinical JJ cord-302215-sqrbj5r4 7 7 evaluation evaluation NN cord-302215-sqrbj5r4 7 8 of of IN cord-302215-sqrbj5r4 7 9 those those DT cord-302215-sqrbj5r4 7 10 drugs drug NNS cord-302215-sqrbj5r4 7 11 are be VBP cord-302215-sqrbj5r4 7 12 compiled compile VBN cord-302215-sqrbj5r4 7 13 in in IN cord-302215-sqrbj5r4 7 14 this this DT cord-302215-sqrbj5r4 7 15 brief brief JJ cord-302215-sqrbj5r4 7 16 report report NN cord-302215-sqrbj5r4 7 17 , , , cord-302215-sqrbj5r4 7 18 although although IN cord-302215-sqrbj5r4 7 19 complete complete JJ cord-302215-sqrbj5r4 7 20 data datum NNS cord-302215-sqrbj5r4 7 21 are be VBP cord-302215-sqrbj5r4 7 22 still still RB cord-302215-sqrbj5r4 7 23 impatiently impatiently RB cord-302215-sqrbj5r4 7 24 awaited await VBN cord-302215-sqrbj5r4 7 25 . . . cord-302215-sqrbj5r4 8 1 Deconfinement Deconfinement NNP cord-302215-sqrbj5r4 8 2 linked link VBN cord-302215-sqrbj5r4 8 3 to to IN cord-302215-sqrbj5r4 8 4 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 8 5 is be VBZ cord-302215-sqrbj5r4 8 6 becoming become VBG cord-302215-sqrbj5r4 8 7 a a DT cord-302215-sqrbj5r4 8 8 huge huge JJ cord-302215-sqrbj5r4 8 9 cause cause NN cord-302215-sqrbj5r4 8 10 of of IN cord-302215-sqrbj5r4 8 11 concern concern NN cord-302215-sqrbj5r4 8 12 for for IN cord-302215-sqrbj5r4 8 13 inhabitants inhabitant NNS cord-302215-sqrbj5r4 8 14 of of IN cord-302215-sqrbj5r4 8 15 many many JJ cord-302215-sqrbj5r4 8 16 countries country NNS cord-302215-sqrbj5r4 8 17 and and CC cord-302215-sqrbj5r4 8 18 their -PRON- PRP$ cord-302215-sqrbj5r4 8 19 political political JJ cord-302215-sqrbj5r4 8 20 leaders leader NNS cord-302215-sqrbj5r4 8 21 . . . cord-302215-sqrbj5r4 9 1 In in IN cord-302215-sqrbj5r4 9 2 the the DT cord-302215-sqrbj5r4 9 3 meantime meantime NN cord-302215-sqrbj5r4 9 4 , , , cord-302215-sqrbj5r4 9 5 researchers researcher NNS cord-302215-sqrbj5r4 9 6 from from IN cord-302215-sqrbj5r4 9 7 diverse diverse JJ cord-302215-sqrbj5r4 9 8 scientific scientific JJ cord-302215-sqrbj5r4 9 9 fields field NNS cord-302215-sqrbj5r4 9 10 are be VBP cord-302215-sqrbj5r4 9 11 gathering gather VBG cord-302215-sqrbj5r4 9 12 their -PRON- PRP$ cord-302215-sqrbj5r4 9 13 efforts effort NNS cord-302215-sqrbj5r4 9 14 in in IN cord-302215-sqrbj5r4 9 15 order order NN cord-302215-sqrbj5r4 9 16 to to TO cord-302215-sqrbj5r4 9 17 combat combat VB cord-302215-sqrbj5r4 9 18 SARS SARS NNP cord-302215-sqrbj5r4 9 19 - - HYPH cord-302215-sqrbj5r4 9 20 CoV-2 CoV-2 NNP cord-302215-sqrbj5r4 9 21 . . . cord-302215-sqrbj5r4 10 1 Targeting target VBG cord-302215-sqrbj5r4 10 2 the the DT cord-302215-sqrbj5r4 10 3 virus virus NN cord-302215-sqrbj5r4 10 4 itself -PRON- PRP cord-302215-sqrbj5r4 10 5 , , , cord-302215-sqrbj5r4 10 6 testing test VBG cord-302215-sqrbj5r4 10 7 infected infected JJ cord-302215-sqrbj5r4 10 8 people people NNS cord-302215-sqrbj5r4 10 9 , , , cord-302215-sqrbj5r4 10 10 offering offer VBG cord-302215-sqrbj5r4 10 11 treatments treatment NNS cord-302215-sqrbj5r4 10 12 , , , cord-302215-sqrbj5r4 10 13 seeking seek VBG cord-302215-sqrbj5r4 10 14 immunized immunize VBN cord-302215-sqrbj5r4 10 15 patients patient NNS cord-302215-sqrbj5r4 10 16 , , , cord-302215-sqrbj5r4 10 17 and and CC cord-302215-sqrbj5r4 10 18 developing develop VBG cord-302215-sqrbj5r4 10 19 vaccines vaccine NNS cord-302215-sqrbj5r4 10 20 are be VBP cord-302215-sqrbj5r4 10 21 among among IN cord-302215-sqrbj5r4 10 22 the the DT cord-302215-sqrbj5r4 10 23 numerous numerous JJ cord-302215-sqrbj5r4 10 24 avenues avenue NNS cord-302215-sqrbj5r4 10 25 actually actually RB cord-302215-sqrbj5r4 10 26 considered consider VBN cord-302215-sqrbj5r4 10 27 . . . cord-302215-sqrbj5r4 11 1 On on IN cord-302215-sqrbj5r4 11 2 March March NNP cord-302215-sqrbj5r4 11 3 13 13 CD cord-302215-sqrbj5r4 11 4 , , , cord-302215-sqrbj5r4 11 5 the the DT cord-302215-sqrbj5r4 11 6 World World NNP cord-302215-sqrbj5r4 11 7 Health Health NNP cord-302215-sqrbj5r4 11 8 Organization Organization NNP cord-302215-sqrbj5r4 11 9 ( ( -LRB- cord-302215-sqrbj5r4 11 10 WHO who WP cord-302215-sqrbj5r4 11 11 ) ) -RRB- cord-302215-sqrbj5r4 11 12 , , , cord-302215-sqrbj5r4 11 13 in in IN cord-302215-sqrbj5r4 11 14 collaboration collaboration NN cord-302215-sqrbj5r4 11 15 with with IN cord-302215-sqrbj5r4 11 16 several several JJ cord-302215-sqrbj5r4 11 17 partners partner NNS cord-302215-sqrbj5r4 11 18 , , , cord-302215-sqrbj5r4 11 19 created create VBD cord-302215-sqrbj5r4 11 20 the the DT cord-302215-sqrbj5r4 11 21 SOLIDARITY SOLIDARITY NNP cord-302215-sqrbj5r4 11 22 Response Response NNP cord-302215-sqrbj5r4 11 23 Fund Fund NNP cord-302215-sqrbj5r4 11 24 to to TO cord-302215-sqrbj5r4 11 25 support support VB cord-302215-sqrbj5r4 11 26 studies study NNS cord-302215-sqrbj5r4 11 27 on on IN cord-302215-sqrbj5r4 11 28 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 11 29 [ [ -LRB- cord-302215-sqrbj5r4 11 30 1 1 CD cord-302215-sqrbj5r4 11 31 ] ] -RRB- cord-302215-sqrbj5r4 11 32 . . . cord-302215-sqrbj5r4 12 1 In in IN cord-302215-sqrbj5r4 12 2 the the DT cord-302215-sqrbj5r4 12 3 wake wake NN cord-302215-sqrbj5r4 12 4 , , , cord-302215-sqrbj5r4 12 5 the the DT cord-302215-sqrbj5r4 12 6 French french JJ cord-302215-sqrbj5r4 12 7 Institut Institut NNP cord-302215-sqrbj5r4 12 8 National National NNP cord-302215-sqrbj5r4 12 9 de de NNP cord-302215-sqrbj5r4 12 10 la la FW cord-302215-sqrbj5r4 12 11 Santé Santé NNP cord-302215-sqrbj5r4 12 12 Et Et NNP cord-302215-sqrbj5r4 12 13 de de FW cord-302215-sqrbj5r4 12 14 la la FW cord-302215-sqrbj5r4 12 15 Recherche Recherche NNP cord-302215-sqrbj5r4 12 16 Médicale Médicale NNP cord-302215-sqrbj5r4 12 17 ( ( -LRB- cord-302215-sqrbj5r4 12 18 INSERM INSERM NNP cord-302215-sqrbj5r4 12 19 ) ) -RRB- cord-302215-sqrbj5r4 12 20 launched launch VBD cord-302215-sqrbj5r4 12 21 a a DT cord-302215-sqrbj5r4 12 22 European european JJ cord-302215-sqrbj5r4 12 23 initiative initiative NN cord-302215-sqrbj5r4 12 24 in in IN cord-302215-sqrbj5r4 12 25 the the DT cord-302215-sqrbj5r4 12 26 form form NN cord-302215-sqrbj5r4 12 27 of of IN cord-302215-sqrbj5r4 12 28 a a DT cord-302215-sqrbj5r4 12 29 clinical clinical JJ cord-302215-sqrbj5r4 12 30 trial trial NN cord-302215-sqrbj5r4 12 31 named name VBN cord-302215-sqrbj5r4 12 32 Discovery Discovery NNP cord-302215-sqrbj5r4 12 33 . . . cord-302215-sqrbj5r4 13 1 A a DT cord-302215-sqrbj5r4 13 2 couple couple NN cord-302215-sqrbj5r4 13 3 of of IN cord-302215-sqrbj5r4 13 4 weeks week NNS cord-302215-sqrbj5r4 13 5 ago ago RB cord-302215-sqrbj5r4 13 6 , , , cord-302215-sqrbj5r4 13 7 we -PRON- PRP cord-302215-sqrbj5r4 13 8 briefly briefly RB cord-302215-sqrbj5r4 13 9 reviewed review VBD cord-302215-sqrbj5r4 13 10 the the DT cord-302215-sqrbj5r4 13 11 first first JJ cord-302215-sqrbj5r4 13 12 potential potential JJ cord-302215-sqrbj5r4 13 13 treatments treatment NNS cord-302215-sqrbj5r4 13 14 under under IN cord-302215-sqrbj5r4 13 15 study study NN cord-302215-sqrbj5r4 13 16 in in IN cord-302215-sqrbj5r4 13 17 those those DT cord-302215-sqrbj5r4 13 18 projects project NNS cord-302215-sqrbj5r4 13 19 [ [ -LRB- cord-302215-sqrbj5r4 13 20 2 2 CD cord-302215-sqrbj5r4 13 21 ] ] -RRB- cord-302215-sqrbj5r4 13 22 . . . cord-302215-sqrbj5r4 14 1 We -PRON- PRP cord-302215-sqrbj5r4 14 2 now now RB cord-302215-sqrbj5r4 14 3 wish wish VBP cord-302215-sqrbj5r4 14 4 to to TO cord-302215-sqrbj5r4 14 5 provide provide VB cord-302215-sqrbj5r4 14 6 an an DT cord-302215-sqrbj5r4 14 7 updated update VBN cord-302215-sqrbj5r4 14 8 situation situation NN cord-302215-sqrbj5r4 14 9 . . . cord-302215-sqrbj5r4 15 1 As as IN cord-302215-sqrbj5r4 15 2 of of IN cord-302215-sqrbj5r4 15 3 May May NNP cord-302215-sqrbj5r4 15 4 4 4 CD cord-302215-sqrbj5r4 15 5 , , , cord-302215-sqrbj5r4 15 6 the the DT cord-302215-sqrbj5r4 15 7 search search NN cord-302215-sqrbj5r4 15 8 term term NN cord-302215-sqrbj5r4 15 9 " " `` cord-302215-sqrbj5r4 15 10 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 15 11 " " '' cord-302215-sqrbj5r4 15 12 in in IN cord-302215-sqrbj5r4 15 13 the the DT cord-302215-sqrbj5r4 15 14 database database NN cord-302215-sqrbj5r4 15 15 of of IN cord-302215-sqrbj5r4 15 16 the the DT cord-302215-sqrbj5r4 15 17 U.S. U.S. NNP cord-302215-sqrbj5r4 15 18 National National NNP cord-302215-sqrbj5r4 15 19 Library Library NNP cord-302215-sqrbj5r4 15 20 of of IN cord-302215-sqrbj5r4 15 21 Medicine Medicine NNP cord-302215-sqrbj5r4 15 22 of of IN cord-302215-sqrbj5r4 15 23 the the DT cord-302215-sqrbj5r4 15 24 National National NNP cord-302215-sqrbj5r4 15 25 Institutes Institutes NNPS cord-302215-sqrbj5r4 15 26 of of IN cord-302215-sqrbj5r4 15 27 Health Health NNP cord-302215-sqrbj5r4 15 28 ( ( -LRB- cord-302215-sqrbj5r4 15 29 Bethesda Bethesda NNP cord-302215-sqrbj5r4 15 30 , , , cord-302215-sqrbj5r4 15 31 Md Md NNP cord-302215-sqrbj5r4 15 32 , , , cord-302215-sqrbj5r4 15 33 USA USA NNP cord-302215-sqrbj5r4 15 34 ) ) -RRB- cord-302215-sqrbj5r4 15 35 [ [ -LRB- cord-302215-sqrbj5r4 15 36 3 3 LS cord-302215-sqrbj5r4 15 37 ] ] -RRB- cord-302215-sqrbj5r4 15 38 gave give VBD cord-302215-sqrbj5r4 15 39 1133 1133 CD cord-302215-sqrbj5r4 15 40 answers answer NNS cord-302215-sqrbj5r4 15 41 . . . cord-302215-sqrbj5r4 16 1 Less Less JJR cord-302215-sqrbj5r4 16 2 than than IN cord-302215-sqrbj5r4 16 3 6 6 CD cord-302215-sqrbj5r4 16 4 weeks week NNS cord-302215-sqrbj5r4 16 5 before before IN cord-302215-sqrbj5r4 16 6 ( ( -LRB- cord-302215-sqrbj5r4 16 7 March March NNP cord-302215-sqrbj5r4 16 8 28 28 CD cord-302215-sqrbj5r4 16 9 ) ) -RRB- cord-302215-sqrbj5r4 16 10 , , , cord-302215-sqrbj5r4 16 11 the the DT cord-302215-sqrbj5r4 16 12 same same JJ cord-302215-sqrbj5r4 16 13 query query NN cord-302215-sqrbj5r4 16 14 had have VBD cord-302215-sqrbj5r4 16 15 resulted result VBN cord-302215-sqrbj5r4 16 16 in in IN cord-302215-sqrbj5r4 16 17 202 202 CD cord-302215-sqrbj5r4 16 18 titles title NNS cord-302215-sqrbj5r4 16 19 ( ( -LRB- cord-302215-sqrbj5r4 16 20 Table table NN cord-302215-sqrbj5r4 16 21 1 1 CD cord-302215-sqrbj5r4 16 22 ) ) -RRB- cord-302215-sqrbj5r4 16 23 . . . cord-302215-sqrbj5r4 17 1 That that DT cord-302215-sqrbj5r4 17 2 incredible incredible JJ cord-302215-sqrbj5r4 17 3 increase increase NN cord-302215-sqrbj5r4 17 4 clearly clearly RB cord-302215-sqrbj5r4 17 5 reflects reflect VBZ cord-302215-sqrbj5r4 17 6 the the DT cord-302215-sqrbj5r4 17 7 worldwide worldwide JJ cord-302215-sqrbj5r4 17 8 concern concern NN cord-302215-sqrbj5r4 17 9 created create VBN cord-302215-sqrbj5r4 17 10 by by IN cord-302215-sqrbj5r4 17 11 the the DT cord-302215-sqrbj5r4 17 12 disease disease NN cord-302215-sqrbj5r4 17 13 . . . cord-302215-sqrbj5r4 18 1 Considering consider VBG cord-302215-sqrbj5r4 18 2 the the DT cord-302215-sqrbj5r4 18 3 most most RBS cord-302215-sqrbj5r4 18 4 cited cite VBN cord-302215-sqrbj5r4 18 5 options option NNS cord-302215-sqrbj5r4 18 6 , , , cord-302215-sqrbj5r4 18 7 as as IN cord-302215-sqrbj5r4 18 8 of of IN cord-302215-sqrbj5r4 18 9 March March NNP cord-302215-sqrbj5r4 18 10 28 28 CD cord-302215-sqrbj5r4 18 11 [ [ -LRB- cord-302215-sqrbj5r4 18 12 2 2 CD cord-302215-sqrbj5r4 18 13 ] ] -RRB- cord-302215-sqrbj5r4 18 14 , , , cord-302215-sqrbj5r4 18 15 for for IN cord-302215-sqrbj5r4 18 16 a a DT cord-302215-sqrbj5r4 18 17 potential potential JJ cord-302215-sqrbj5r4 18 18 treatment treatment NN cord-302215-sqrbj5r4 18 19 , , , cord-302215-sqrbj5r4 18 20 we -PRON- PRP cord-302215-sqrbj5r4 18 21 analyzed analyze VBD cord-302215-sqrbj5r4 18 22 the the DT cord-302215-sqrbj5r4 18 23 evolution evolution NN cord-302215-sqrbj5r4 18 24 of of IN cord-302215-sqrbj5r4 18 25 the the DT cord-302215-sqrbj5r4 18 26 number number NN cord-302215-sqrbj5r4 18 27 of of IN cord-302215-sqrbj5r4 18 28 clinical clinical JJ cord-302215-sqrbj5r4 18 29 trials trial NNS cord-302215-sqrbj5r4 18 30 on on IN cord-302215-sqrbj5r4 18 31 April April NNP cord-302215-sqrbj5r4 18 32 8 8 CD cord-302215-sqrbj5r4 18 33 , , , cord-302215-sqrbj5r4 18 34 April April NNP cord-302215-sqrbj5r4 18 35 28 28 CD cord-302215-sqrbj5r4 18 36 , , , cord-302215-sqrbj5r4 18 37 and and CC cord-302215-sqrbj5r4 18 38 May May NNP cord-302215-sqrbj5r4 18 39 4 4 CD cord-302215-sqrbj5r4 18 40 . . . cord-302215-sqrbj5r4 19 1 As as IN cord-302215-sqrbj5r4 19 2 indicated indicate VBN cord-302215-sqrbj5r4 19 3 in in IN cord-302215-sqrbj5r4 19 4 Table Table NNP cord-302215-sqrbj5r4 19 5 1 1 CD cord-302215-sqrbj5r4 19 6 , , , cord-302215-sqrbj5r4 19 7 actually actually RB cord-302215-sqrbj5r4 19 8 , , , cord-302215-sqrbj5r4 19 9 researches research VBZ cord-302215-sqrbj5r4 19 10 on on IN cord-302215-sqrbj5r4 19 11 the the DT cord-302215-sqrbj5r4 19 12 efficacy efficacy NN cord-302215-sqrbj5r4 19 13 of of IN cord-302215-sqrbj5r4 19 14 hydroxychloroquine hydroxychloroquine NNP cord-302215-sqrbj5r4 19 15 ( ( -LRB- cord-302215-sqrbj5r4 19 16 4 4 CD cord-302215-sqrbj5r4 19 17 , , , cord-302215-sqrbj5r4 19 18 Figure figure NN cord-302215-sqrbj5r4 19 19 1 1 CD cord-302215-sqrbj5r4 19 20 ) ) -RRB- cord-302215-sqrbj5r4 19 21 and and CC cord-302215-sqrbj5r4 19 22 plasma plasma NN cord-302215-sqrbj5r4 19 23 therapy therapy NN cord-302215-sqrbj5r4 19 24 constitute constitute VBP cord-302215-sqrbj5r4 19 25 , , , cord-302215-sqrbj5r4 19 26 by by IN cord-302215-sqrbj5r4 19 27 far far RB cord-302215-sqrbj5r4 19 28 , , , cord-302215-sqrbj5r4 19 29 the the DT cord-302215-sqrbj5r4 19 30 most most RBS cord-302215-sqrbj5r4 19 31 explored explore VBN cord-302215-sqrbj5r4 19 32 fields field NNS cord-302215-sqrbj5r4 19 33 . . . cord-302215-sqrbj5r4 20 1 They -PRON- PRP cord-302215-sqrbj5r4 20 2 are be VBP cord-302215-sqrbj5r4 20 3 followed follow VBN cord-302215-sqrbj5r4 20 4 by by IN cord-302215-sqrbj5r4 20 5 studies study NNS cord-302215-sqrbj5r4 20 6 involving involve VBG cord-302215-sqrbj5r4 20 7 chloroquine chloroquine NNP cord-302215-sqrbj5r4 20 8 ( ( -LRB- cord-302215-sqrbj5r4 20 9 5 5 CD cord-302215-sqrbj5r4 20 10 ) ) -RRB- cord-302215-sqrbj5r4 20 11 and and CC cord-302215-sqrbj5r4 20 12 the the DT cord-302215-sqrbj5r4 20 13 combination combination NN cord-302215-sqrbj5r4 20 14 lopinavir lopinavir NNS cord-302215-sqrbj5r4 20 15 ( ( -LRB- cord-302215-sqrbj5r4 20 16 2)/ritonavir 2)/ritonavir CD cord-302215-sqrbj5r4 20 17 ( ( -LRB- cord-302215-sqrbj5r4 20 18 3 3 CD cord-302215-sqrbj5r4 20 19 ) ) -RRB- cord-302215-sqrbj5r4 20 20 . . . cord-302215-sqrbj5r4 21 1 To to IN cord-302215-sqrbj5r4 21 2 date date NN cord-302215-sqrbj5r4 21 3 , , , cord-302215-sqrbj5r4 21 4 tocilizumab tocilizumab NNP cord-302215-sqrbj5r4 21 5 emerges emerge VBZ cord-302215-sqrbj5r4 21 6 as as IN cord-302215-sqrbj5r4 21 7 a a DT cord-302215-sqrbj5r4 21 8 lead lead NN cord-302215-sqrbj5r4 21 9 in in IN cord-302215-sqrbj5r4 21 10 the the DT cord-302215-sqrbj5r4 21 11 category category NN cord-302215-sqrbj5r4 21 12 of of IN cord-302215-sqrbj5r4 21 13 monoclonal monoclonal JJ cord-302215-sqrbj5r4 21 14 antibodies antibody NNS cord-302215-sqrbj5r4 21 15 and and CC cord-302215-sqrbj5r4 21 16 cell cell NN cord-302215-sqrbj5r4 21 17 therapy therapy NN cord-302215-sqrbj5r4 21 18 is be VBZ cord-302215-sqrbj5r4 21 19 focused focus VBN cord-302215-sqrbj5r4 21 20 on on IN cord-302215-sqrbj5r4 21 21 the the DT cord-302215-sqrbj5r4 21 22 potentialities potentiality NNS cord-302215-sqrbj5r4 21 23 of of IN cord-302215-sqrbj5r4 21 24 mesenchymal mesenchymal JJ cord-302215-sqrbj5r4 21 25 stem stem NN cord-302215-sqrbj5r4 21 26 cells cell NNS cord-302215-sqrbj5r4 21 27 . . . cord-302215-sqrbj5r4 22 1 Many many JJ cord-302215-sqrbj5r4 22 2 other other JJ cord-302215-sqrbj5r4 22 3 small small JJ cord-302215-sqrbj5r4 22 4 molecules molecule NNS cord-302215-sqrbj5r4 22 5 ( ( -LRB- cord-302215-sqrbj5r4 22 6 essentially essentially RB cord-302215-sqrbj5r4 22 7 antiviral antiviral JJ cord-302215-sqrbj5r4 22 8 agents agent NNS cord-302215-sqrbj5r4 22 9 ) ) -RRB- cord-302215-sqrbj5r4 22 10 and and CC cord-302215-sqrbj5r4 22 11 proteins protein NNS cord-302215-sqrbj5r4 22 12 remain remain VBP cord-302215-sqrbj5r4 22 13 attractive attractive JJ cord-302215-sqrbj5r4 22 14 subjects subject NNS cord-302215-sqrbj5r4 22 15 of of IN cord-302215-sqrbj5r4 22 16 trials trial NNS cord-302215-sqrbj5r4 22 17 , , , cord-302215-sqrbj5r4 22 18 but but CC cord-302215-sqrbj5r4 22 19 to to IN cord-302215-sqrbj5r4 22 20 a a DT cord-302215-sqrbj5r4 22 21 lesser less JJR cord-302215-sqrbj5r4 22 22 extent extent NN cord-302215-sqrbj5r4 22 23 . . . cord-302215-sqrbj5r4 23 1 Comparison comparison NN cord-302215-sqrbj5r4 23 2 with with IN cord-302215-sqrbj5r4 23 3 clinical clinical JJ cord-302215-sqrbj5r4 23 4 trials trial NNS cord-302215-sqrbj5r4 23 5 reported report VBN cord-302215-sqrbj5r4 23 6 in in IN cord-302215-sqrbj5r4 23 7 the the DT cord-302215-sqrbj5r4 23 8 Chinese Chinese NNP cord-302215-sqrbj5r4 23 9 Clinical Clinical NNP cord-302215-sqrbj5r4 23 10 Trial Trial NNP cord-302215-sqrbj5r4 23 11 Registry Registry NNP cord-302215-sqrbj5r4 23 12 [ [ -LRB- cord-302215-sqrbj5r4 23 13 4 4 LS cord-302215-sqrbj5r4 23 14 ] ] -RRB- cord-302215-sqrbj5r4 23 15 deserves deserve VBZ cord-302215-sqrbj5r4 23 16 some some DT cord-302215-sqrbj5r4 23 17 attention attention NN cord-302215-sqrbj5r4 23 18 . . . cord-302215-sqrbj5r4 24 1 In in IN cord-302215-sqrbj5r4 24 2 that that DT cord-302215-sqrbj5r4 24 3 registry registry NN cord-302215-sqrbj5r4 24 4 , , , cord-302215-sqrbj5r4 24 5 the the DT cord-302215-sqrbj5r4 24 6 vast vast JJ cord-302215-sqrbj5r4 24 7 majority majority NN cord-302215-sqrbj5r4 24 8 of of IN cord-302215-sqrbj5r4 24 9 trials trial NNS cord-302215-sqrbj5r4 24 10 concern concern VBP cord-302215-sqrbj5r4 24 11 traditional traditional JJ cord-302215-sqrbj5r4 24 12 Chinese chinese JJ cord-302215-sqrbj5r4 24 13 medicine medicine NN cord-302215-sqrbj5r4 24 14 ( ( -LRB- cord-302215-sqrbj5r4 24 15 plant plant NN cord-302215-sqrbj5r4 24 16 extracts extract NNS cord-302215-sqrbj5r4 24 17 ) ) -RRB- cord-302215-sqrbj5r4 24 18 . . . cord-302215-sqrbj5r4 24 19 _SP cord-302215-sqrbj5r4 25 1 On on IN cord-302215-sqrbj5r4 25 2 March March NNP cord-302215-sqrbj5r4 25 3 22 22 CD cord-302215-sqrbj5r4 25 4 , , , cord-302215-sqrbj5r4 25 5 the the DT cord-302215-sqrbj5r4 25 6 INSERM INSERM NNP cord-302215-sqrbj5r4 25 7 announced announce VBD cord-302215-sqrbj5r4 25 8 the the DT cord-302215-sqrbj5r4 25 9 start start NN cord-302215-sqrbj5r4 25 10 of of IN cord-302215-sqrbj5r4 25 11 a a DT cord-302215-sqrbj5r4 25 12 European european JJ cord-302215-sqrbj5r4 25 13 adaptive adaptive JJ cord-302215-sqrbj5r4 25 14 clinical clinical JJ cord-302215-sqrbj5r4 25 15 trial trial NN cord-302215-sqrbj5r4 25 16 entitled entitle VBN cord-302215-sqrbj5r4 25 17 " " `` cord-302215-sqrbj5r4 25 18 Trial Trial NNP cord-302215-sqrbj5r4 25 19 of of IN cord-302215-sqrbj5r4 25 20 Treatments Treatments NNPS cord-302215-sqrbj5r4 25 21 for for IN cord-302215-sqrbj5r4 25 22 COVID-19 covid-19 CD cord-302215-sqrbj5r4 25 23 in in IN cord-302215-sqrbj5r4 25 24 Hospitalized Hospitalized NNP cord-302215-sqrbj5r4 25 25 Adults Adults NNPS cord-302215-sqrbj5r4 25 26 ( ( -LRB- cord-302215-sqrbj5r4 25 27 DisCoVeRy DisCoVeRy NNP cord-302215-sqrbj5r4 25 28 ) ) -RRB- cord-302215-sqrbj5r4 25 29 " " '' cord-302215-sqrbj5r4 25 30 ( ( -LRB- cord-302215-sqrbj5r4 25 31 NCT04315948 NCT04315948 NNP cord-302215-sqrbj5r4 25 32 ) ) -RRB- cord-302215-sqrbj5r4 25 33 . . . cord-302215-sqrbj5r4 26 1 [ [ -LRB- cord-302215-sqrbj5r4 26 2 5 5 CD cord-302215-sqrbj5r4 26 3 ] ] -RRB- cord-302215-sqrbj5r4 27 1 The the DT cord-302215-sqrbj5r4 27 2 trial trial NN cord-302215-sqrbj5r4 27 3 is be VBZ cord-302215-sqrbj5r4 27 4 supposed suppose VBN cord-302215-sqrbj5r4 27 5 to to TO cord-302215-sqrbj5r4 27 6 enroll enroll VB cord-302215-sqrbj5r4 27 7 3,100 3,100 CD cord-302215-sqrbj5r4 27 8 patients patient NNS cord-302215-sqrbj5r4 27 9 in in IN cord-302215-sqrbj5r4 27 10 seven seven CD cord-302215-sqrbj5r4 27 11 countries country NNS cord-302215-sqrbj5r4 27 12 , , , cord-302215-sqrbj5r4 27 13 namely namely RB cord-302215-sqrbj5r4 27 14 France France NNP cord-302215-sqrbj5r4 27 15 , , , cord-302215-sqrbj5r4 27 16 Spain Spain NNP cord-302215-sqrbj5r4 27 17 , , , cord-302215-sqrbj5r4 27 18 the the DT cord-302215-sqrbj5r4 27 19 United United NNP cord-302215-sqrbj5r4 27 20 Kingdom Kingdom NNP cord-302215-sqrbj5r4 27 21 , , , cord-302215-sqrbj5r4 27 22 Germany Germany NNP cord-302215-sqrbj5r4 27 23 , , , cord-302215-sqrbj5r4 27 24 Luxemburg Luxemburg NNP cord-302215-sqrbj5r4 27 25 , , , cord-302215-sqrbj5r4 27 26 the the DT cord-302215-sqrbj5r4 27 27 Netherlands Netherlands NNP cord-302215-sqrbj5r4 27 28 , , , cord-302215-sqrbj5r4 27 29 and and CC cord-302215-sqrbj5r4 27 30 Belgium Belgium NNP cord-302215-sqrbj5r4 27 31 . . . cord-302215-sqrbj5r4 28 1 [ [ -LRB- cord-302215-sqrbj5r4 28 2 6 6 LS cord-302215-sqrbj5r4 28 3 ] ] -RRB- cord-302215-sqrbj5r4 28 4 It -PRON- PRP cord-302215-sqrbj5r4 28 5 started start VBD cord-302215-sqrbj5r4 28 6 in in IN cord-302215-sqrbj5r4 28 7 three three CD cord-302215-sqrbj5r4 28 8 French french JJ cord-302215-sqrbj5r4 28 9 hospitals hospital NNS cord-302215-sqrbj5r4 28 10 : : : cord-302215-sqrbj5r4 28 11 Centre Centre NNP cord-302215-sqrbj5r4 28 12 Hospitalier Hospitalier NNP cord-302215-sqrbj5r4 28 13 Régional Régional NNP cord-302215-sqrbj5r4 28 14 Universitaire Universitaire NNP cord-302215-sqrbj5r4 28 15 de de FW cord-302215-sqrbj5r4 28 16 Lille Lille NNP cord-302215-sqrbj5r4 28 17 ( ( -LRB- cord-302215-sqrbj5r4 28 18 Lille Lille NNP cord-302215-sqrbj5r4 28 19 , , , cord-302215-sqrbj5r4 28 20 France France NNP cord-302215-sqrbj5r4 28 21 ) ) -RRB- cord-302215-sqrbj5r4 28 22 , , , cord-302215-sqrbj5r4 28 23 Centre Centre NNP cord-302215-sqrbj5r4 28 24 Hospitalier Hospitalier NNP cord-302215-sqrbj5r4 28 25 Universitaire Universitaire NNP cord-302215-sqrbj5r4 28 26 de de IN cord-302215-sqrbj5r4 28 27 Nantes Nantes NNP cord-302215-sqrbj5r4 28 28 ( ( -LRB- cord-302215-sqrbj5r4 28 29 Nantes Nantes NNP cord-302215-sqrbj5r4 28 30 , , , cord-302215-sqrbj5r4 28 31 France France NNP cord-302215-sqrbj5r4 28 32 ) ) -RRB- cord-302215-sqrbj5r4 28 33 , , , cord-302215-sqrbj5r4 28 34 and and CC cord-302215-sqrbj5r4 28 35 Assistance Assistance NNP cord-302215-sqrbj5r4 28 36 Publique Publique NNP cord-302215-sqrbj5r4 28 37 Hôpitaux Hôpitaux NNP cord-302215-sqrbj5r4 28 38 de de NNP cord-302215-sqrbj5r4 28 39 Paris Paris NNP cord-302215-sqrbj5r4 28 40 - - HYPH cord-302215-sqrbj5r4 28 41 Bichat Bichat NNP cord-302215-sqrbj5r4 28 42 Claude Claude NNP cord-302215-sqrbj5r4 28 43 Bernard Bernard NNP cord-302215-sqrbj5r4 28 44 ( ( -LRB- cord-302215-sqrbj5r4 28 45 Paris Paris NNP cord-302215-sqrbj5r4 28 46 , , , cord-302215-sqrbj5r4 28 47 France France NNP cord-302215-sqrbj5r4 28 48 ) ) -RRB- cord-302215-sqrbj5r4 28 49 . . . cord-302215-sqrbj5r4 29 1 To to IN cord-302215-sqrbj5r4 29 2 date date NN cord-302215-sqrbj5r4 29 3 , , , cord-302215-sqrbj5r4 29 4 there there EX cord-302215-sqrbj5r4 29 5 are be VBP cord-302215-sqrbj5r4 29 6 34 34 CD cord-302215-sqrbj5r4 29 7 study study NN cord-302215-sqrbj5r4 29 8 hospitals hospital NNS cord-302215-sqrbj5r4 29 9 , , , cord-302215-sqrbj5r4 29 10 32 32 CD cord-302215-sqrbj5r4 29 11 in in IN cord-302215-sqrbj5r4 29 12 France France NNP cord-302215-sqrbj5r4 29 13 and and CC cord-302215-sqrbj5r4 29 14 2 2 CD cord-302215-sqrbj5r4 29 15 in in IN cord-302215-sqrbj5r4 29 16 Luxembourg Luxembourg NNP cord-302215-sqrbj5r4 29 17 . . . cord-302215-sqrbj5r4 30 1 The the DT cord-302215-sqrbj5r4 30 2 five five CD cord-302215-sqrbj5r4 30 3 other other JJ cord-302215-sqrbj5r4 30 4 countries country NNS cord-302215-sqrbj5r4 30 5 are be VBP cord-302215-sqrbj5r4 30 6 not not RB cord-302215-sqrbj5r4 30 7 yet yet RB cord-302215-sqrbj5r4 30 8 represented represent VBN cord-302215-sqrbj5r4 30 9 [ [ -LRB- cord-302215-sqrbj5r4 30 10 7 7 CD cord-302215-sqrbj5r4 30 11 ] ] -RRB- cord-302215-sqrbj5r4 30 12 . . . cord-302215-sqrbj5r4 31 1 Initially initially RB cord-302215-sqrbj5r4 31 2 , , , cord-302215-sqrbj5r4 31 3 the the DT cord-302215-sqrbj5r4 31 4 drugs drug NNS cord-302215-sqrbj5r4 31 5 to to TO cord-302215-sqrbj5r4 31 6 be be VB cord-302215-sqrbj5r4 31 7 evaluated evaluate VBN cord-302215-sqrbj5r4 31 8 in in IN cord-302215-sqrbj5r4 31 9 the the DT cord-302215-sqrbj5r4 31 10 Discovery Discovery NNP cord-302215-sqrbj5r4 31 11 project project NN cord-302215-sqrbj5r4 31 12 are be VBP cord-302215-sqrbj5r4 31 13 • • NNP cord-302215-sqrbj5r4 31 14 remdesivir remdesivir NNP cord-302215-sqrbj5r4 31 15 ( ( -LRB- cord-302215-sqrbj5r4 31 16 1 1 CD cord-302215-sqrbj5r4 31 17 ) ) -RRB- cord-302215-sqrbj5r4 31 18 ; ; : cord-302215-sqrbj5r4 31 19 • • XX cord-302215-sqrbj5r4 31 20 the the DT cord-302215-sqrbj5r4 31 21 combination combination NN cord-302215-sqrbj5r4 31 22 lopinavir lopinavir NNS cord-302215-sqrbj5r4 31 23 ( ( -LRB- cord-302215-sqrbj5r4 31 24 2)/ritonavir 2)/ritonavir CD cord-302215-sqrbj5r4 31 25 ( ( -LRB- cord-302215-sqrbj5r4 31 26 3 3 CD cord-302215-sqrbj5r4 31 27 ) ) -RRB- cord-302215-sqrbj5r4 31 28 , , , cord-302215-sqrbj5r4 31 29 eventually eventually RB cord-302215-sqrbj5r4 31 30 with with IN cord-302215-sqrbj5r4 31 31 the the DT cord-302215-sqrbj5r4 31 32 addition addition NN cord-302215-sqrbj5r4 31 33 of of IN cord-302215-sqrbj5r4 31 34 interferon interferon NNP cord-302215-sqrbj5r4 31 35 β-1a β-1a NNP cord-302215-sqrbj5r4 31 36 ; ; . cord-302215-sqrbj5r4 32 1 • • NNP cord-302215-sqrbj5r4 32 2 hydroxychloroquine hydroxychloroquine NNP cord-302215-sqrbj5r4 32 3 ( ( -LRB- cord-302215-sqrbj5r4 32 4 4 4 CD cord-302215-sqrbj5r4 32 5 ) ) -RRB- cord-302215-sqrbj5r4 32 6 or or CC cord-302215-sqrbj5r4 32 7 chloroquine chloroquine NN cord-302215-sqrbj5r4 32 8 ( ( -LRB- cord-302215-sqrbj5r4 32 9 5 5 CD cord-302215-sqrbj5r4 32 10 ) ) -RRB- cord-302215-sqrbj5r4 32 11 , , , cord-302215-sqrbj5r4 32 12 eventually eventually RB cord-302215-sqrbj5r4 32 13 associated associate VBN cord-302215-sqrbj5r4 32 14 with with IN cord-302215-sqrbj5r4 32 15 an an DT cord-302215-sqrbj5r4 32 16 antibiotic antibiotic NN cord-302215-sqrbj5r4 32 17 ( ( -LRB- cord-302215-sqrbj5r4 32 18 azithromycin azithromycin NN cord-302215-sqrbj5r4 32 19 or or CC cord-302215-sqrbj5r4 32 20 other other JJ cord-302215-sqrbj5r4 32 21 ) ) -RRB- cord-302215-sqrbj5r4 32 22 . . . cord-302215-sqrbj5r4 33 1 As as IN cord-302215-sqrbj5r4 33 2 indicated indicate VBN cord-302215-sqrbj5r4 33 3 in in IN cord-302215-sqrbj5r4 33 4 the the DT cord-302215-sqrbj5r4 33 5 protocol protocol NN cord-302215-sqrbj5r4 33 6 , , , cord-302215-sqrbj5r4 33 7 exclusion exclusion NN cord-302215-sqrbj5r4 33 8 criteria criterion NNS cord-302215-sqrbj5r4 33 9 comprise comprise VBP cord-302215-sqrbj5r4 33 10 , , , cord-302215-sqrbj5r4 33 11 among among IN cord-302215-sqrbj5r4 33 12 others other NNS cord-302215-sqrbj5r4 33 13 , , , cord-302215-sqrbj5r4 34 1 • • NNP cord-302215-sqrbj5r4 35 1 Patients patient NNS cord-302215-sqrbj5r4 35 2 with with IN cord-302215-sqrbj5r4 35 3 liver liver NN cord-302215-sqrbj5r4 35 4 damage damage NN cord-302215-sqrbj5r4 35 5 as as IN cord-302215-sqrbj5r4 35 6 indicated indicate VBN cord-302215-sqrbj5r4 35 7 by by IN cord-302215-sqrbj5r4 35 8 alanine alanine NN cord-302215-sqrbj5r4 35 9 / / SYM cord-302215-sqrbj5r4 35 10 aspartate aspartate NN cord-302215-sqrbj5r4 35 11 aminotransferases aminotransferase NNS cord-302215-sqrbj5r4 35 12 levels level NNS cord-302215-sqrbj5r4 35 13 , , , cord-302215-sqrbj5r4 35 14 in in IN cord-302215-sqrbj5r4 35 15 blood blood NN cord-302215-sqrbj5r4 35 16 , , , cord-302215-sqrbj5r4 35 17 more more JJR cord-302215-sqrbj5r4 35 18 than than IN cord-302215-sqrbj5r4 35 19 5 5 CD cord-302215-sqrbj5r4 35 20 times time NNS cord-302215-sqrbj5r4 35 21 the the DT cord-302215-sqrbj5r4 35 22 upper upper JJ cord-302215-sqrbj5r4 35 23 limit limit NN cord-302215-sqrbj5r4 35 24 of of IN cord-302215-sqrbj5r4 35 25 normal normal JJ cord-302215-sqrbj5r4 36 1 ; ; : cord-302215-sqrbj5r4 36 2 • • NNS cord-302215-sqrbj5r4 36 3 Patients patient NNS cord-302215-sqrbj5r4 36 4 suffering suffer VBG cord-302215-sqrbj5r4 36 5 of of IN cord-302215-sqrbj5r4 36 6 severe severe JJ cord-302215-sqrbj5r4 36 7 chronic chronic JJ cord-302215-sqrbj5r4 36 8 kidney kidney NN cord-302215-sqrbj5r4 36 9 disease disease NN cord-302215-sqrbj5r4 36 10 ; ; . cord-302215-sqrbj5r4 37 1 • • NNP cord-302215-sqrbj5r4 37 2 Patients patient NNS cord-302215-sqrbj5r4 37 3 using use VBG cord-302215-sqrbj5r4 37 4 medications medication NNS cord-302215-sqrbj5r4 37 5 that that WDT cord-302215-sqrbj5r4 37 6 are be VBP cord-302215-sqrbj5r4 37 7 contraindicated contraindicate VBN cord-302215-sqrbj5r4 37 8 with with IN cord-302215-sqrbj5r4 37 9 lopinavir lopinavir NNS cord-302215-sqrbj5r4 37 10 / / SYM cord-302215-sqrbj5r4 37 11 ritonavir ritonavir NNS cord-302215-sqrbj5r4 37 12 ( ( -LRB- cord-302215-sqrbj5r4 37 13 e.g. e.g. RB cord-302215-sqrbj5r4 37 14 , , , cord-302215-sqrbj5r4 37 15 amiodarone amiodarone NN cord-302215-sqrbj5r4 37 16 , , , cord-302215-sqrbj5r4 37 17 colchicine colchicine NN cord-302215-sqrbj5r4 37 18 , , , cord-302215-sqrbj5r4 37 19 simvastatine simvastatine NN cord-302215-sqrbj5r4 37 20 ) ) -RRB- cord-302215-sqrbj5r4 37 21 or or CC cord-302215-sqrbj5r4 37 22 hydroxychloroquine hydroxychloroquine NNP cord-302215-sqrbj5r4 37 23 ( ( -LRB- cord-302215-sqrbj5r4 37 24 e.g. e.g. RB cord-302215-sqrbj5r4 37 25 , , , cord-302215-sqrbj5r4 37 26 citalopram citalopram NNP cord-302215-sqrbj5r4 37 27 , , , cord-302215-sqrbj5r4 37 28 escitalopram escitalopram NN cord-302215-sqrbj5r4 37 29 , , , cord-302215-sqrbj5r4 37 30 hydroxyzine hydroxyzine NN cord-302215-sqrbj5r4 37 31 , , , cord-302215-sqrbj5r4 37 32 domperidone domperidone NN cord-302215-sqrbj5r4 37 33 , , , cord-302215-sqrbj5r4 37 34 piperaquine piperaquine NNP cord-302215-sqrbj5r4 37 35 ) ) -RRB- cord-302215-sqrbj5r4 37 36 . . . cord-302215-sqrbj5r4 38 1 It -PRON- PRP cord-302215-sqrbj5r4 38 2 is be VBZ cord-302215-sqrbj5r4 38 3 noteworthy noteworthy JJ cord-302215-sqrbj5r4 38 4 that that IN cord-302215-sqrbj5r4 38 5 suffering suffering NN cord-302215-sqrbj5r4 38 6 of of IN cord-302215-sqrbj5r4 38 7 cardiac cardiac JJ cord-302215-sqrbj5r4 38 8 problems problem NNS cord-302215-sqrbj5r4 38 9 was be VBD cord-302215-sqrbj5r4 38 10 not not RB cord-302215-sqrbj5r4 38 11 a a DT cord-302215-sqrbj5r4 38 12 criterion criterion NN cord-302215-sqrbj5r4 38 13 of of IN cord-302215-sqrbj5r4 38 14 exclusion exclusion NN cord-302215-sqrbj5r4 38 15 from from IN cord-302215-sqrbj5r4 38 16 the the DT cord-302215-sqrbj5r4 38 17 study study NN cord-302215-sqrbj5r4 38 18 . . . cord-302215-sqrbj5r4 39 1 The the DT cord-302215-sqrbj5r4 39 2 estimated estimated JJ cord-302215-sqrbj5r4 39 3 study study NN cord-302215-sqrbj5r4 39 4 completion completion NN cord-302215-sqrbj5r4 39 5 date date NN cord-302215-sqrbj5r4 39 6 has have VBZ cord-302215-sqrbj5r4 39 7 been be VBN cord-302215-sqrbj5r4 39 8 fixed fix VBN cord-302215-sqrbj5r4 39 9 on on IN cord-302215-sqrbj5r4 39 10 March March NNP cord-302215-sqrbj5r4 39 11 2023 2023 CD cord-302215-sqrbj5r4 39 12 , , , cord-302215-sqrbj5r4 39 13 3 3 CD cord-302215-sqrbj5r4 39 14 years year NNS cord-302215-sqrbj5r4 39 15 after after IN cord-302215-sqrbj5r4 39 16 the the DT cord-302215-sqrbj5r4 39 17 starting start VBG cord-302215-sqrbj5r4 39 18 date date NN cord-302215-sqrbj5r4 39 19 . . . cord-302215-sqrbj5r4 40 1 Meanwhile meanwhile RB cord-302215-sqrbj5r4 40 2 , , , cord-302215-sqrbj5r4 40 3 some some DT cord-302215-sqrbj5r4 40 4 partial partial JJ cord-302215-sqrbj5r4 40 5 reports report NNS cord-302215-sqrbj5r4 40 6 on on IN cord-302215-sqrbj5r4 40 7 the the DT cord-302215-sqrbj5r4 40 8 efficacy efficacy NN cord-302215-sqrbj5r4 40 9 of of IN cord-302215-sqrbj5r4 40 10 those those DT cord-302215-sqrbj5r4 40 11 molecules molecule NNS cord-302215-sqrbj5r4 40 12 in in IN cord-302215-sqrbj5r4 40 13 the the DT cord-302215-sqrbj5r4 40 14 treatment treatment NN cord-302215-sqrbj5r4 40 15 of of IN cord-302215-sqrbj5r4 40 16 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 40 17 have have VBP cord-302215-sqrbj5r4 40 18 been be VBN cord-302215-sqrbj5r4 40 19 made make VBN cord-302215-sqrbj5r4 40 20 public public JJ cord-302215-sqrbj5r4 40 21 . . . cord-302215-sqrbj5r4 41 1 Their -PRON- PRP$ cord-302215-sqrbj5r4 41 2 conclusions conclusion NNS cord-302215-sqrbj5r4 41 3 are be VBP cord-302215-sqrbj5r4 41 4 often often RB cord-302215-sqrbj5r4 41 5 contradictory contradictory JJ cord-302215-sqrbj5r4 41 6 as as IN cord-302215-sqrbj5r4 41 7 reported report VBN cord-302215-sqrbj5r4 41 8 hereafter hereafter RB cord-302215-sqrbj5r4 41 9 . . . cord-302215-sqrbj5r4 42 1 Pharmaceuticals pharmaceutical NNS cord-302215-sqrbj5r4 42 2 2020 2020 CD cord-302215-sqrbj5r4 42 3 , , , cord-302215-sqrbj5r4 42 4 13 13 CD cord-302215-sqrbj5r4 42 5 , , , cord-302215-sqrbj5r4 42 6 x x NN cord-302215-sqrbj5r4 42 7 FOR for IN cord-302215-sqrbj5r4 42 8 PEER peer NN cord-302215-sqrbj5r4 42 9 REVIEW REVIEW NNP cord-302215-sqrbj5r4 42 10 3 3 CD cord-302215-sqrbj5r4 42 11 of of IN cord-302215-sqrbj5r4 43 1 9 9 CD cord-302215-sqrbj5r4 43 2   NNS cord-302215-sqrbj5r4 43 3 Patients patient NNS cord-302215-sqrbj5r4 43 4 with with IN cord-302215-sqrbj5r4 43 5 liver liver NN cord-302215-sqrbj5r4 43 6 damage damage NN cord-302215-sqrbj5r4 43 7 as as IN cord-302215-sqrbj5r4 43 8 indicated indicate VBN cord-302215-sqrbj5r4 43 9 by by IN cord-302215-sqrbj5r4 43 10 alanine alanine NN cord-302215-sqrbj5r4 43 11 / / SYM cord-302215-sqrbj5r4 43 12 aspartate aspartate NN cord-302215-sqrbj5r4 43 13 aminotransferases aminotransferase NNS cord-302215-sqrbj5r4 43 14 levels level NNS cord-302215-sqrbj5r4 43 15 , , , cord-302215-sqrbj5r4 43 16 in in IN cord-302215-sqrbj5r4 43 17 blood blood NN cord-302215-sqrbj5r4 43 18 , , , cord-302215-sqrbj5r4 43 19 more more JJR cord-302215-sqrbj5r4 43 20 than than IN cord-302215-sqrbj5r4 43 21 5 5 CD cord-302215-sqrbj5r4 43 22 times time NNS cord-302215-sqrbj5r4 43 23 the the DT cord-302215-sqrbj5r4 43 24 upper upper JJ cord-302215-sqrbj5r4 43 25 limit limit NN cord-302215-sqrbj5r4 43 26 of of IN cord-302215-sqrbj5r4 43 27 normal normal JJ cord-302215-sqrbj5r4 43 28 ; ; : cord-302215-sqrbj5r4 43 29   NFP cord-302215-sqrbj5r4 43 30 Patients patient NNS cord-302215-sqrbj5r4 43 31 suffering suffer VBG cord-302215-sqrbj5r4 43 32 of of IN cord-302215-sqrbj5r4 43 33 severe severe JJ cord-302215-sqrbj5r4 43 34 chronic chronic JJ cord-302215-sqrbj5r4 43 35 kidney kidney NN cord-302215-sqrbj5r4 43 36 disease disease NN cord-302215-sqrbj5r4 43 37 ; ; : cord-302215-sqrbj5r4 43 38   NFP cord-302215-sqrbj5r4 43 39 Patients patient NNS cord-302215-sqrbj5r4 43 40 using use VBG cord-302215-sqrbj5r4 43 41 medications medication NNS cord-302215-sqrbj5r4 43 42 that that WDT cord-302215-sqrbj5r4 43 43 are be VBP cord-302215-sqrbj5r4 43 44 contraindicated contraindicate VBN cord-302215-sqrbj5r4 43 45 with with IN cord-302215-sqrbj5r4 43 46 lopinavir lopinavir NNS cord-302215-sqrbj5r4 43 47 / / SYM cord-302215-sqrbj5r4 43 48 ritonavir ritonavir NNS cord-302215-sqrbj5r4 43 49 ( ( -LRB- cord-302215-sqrbj5r4 43 50 e.g. e.g. RB cord-302215-sqrbj5r4 43 51 , , , cord-302215-sqrbj5r4 43 52 amiodarone amiodarone NN cord-302215-sqrbj5r4 43 53 , , , cord-302215-sqrbj5r4 43 54 colchicine colchicine NN cord-302215-sqrbj5r4 43 55 , , , cord-302215-sqrbj5r4 43 56 simvastatine simvastatine NN cord-302215-sqrbj5r4 43 57 ) ) -RRB- cord-302215-sqrbj5r4 43 58 or or CC cord-302215-sqrbj5r4 43 59 hydroxychloroquine hydroxychloroquine NNP cord-302215-sqrbj5r4 43 60 ( ( -LRB- cord-302215-sqrbj5r4 43 61 e.g. e.g. RB cord-302215-sqrbj5r4 43 62 , , , cord-302215-sqrbj5r4 43 63 citalopram citalopram NNP cord-302215-sqrbj5r4 43 64 , , , cord-302215-sqrbj5r4 43 65 escitalopram escitalopram NN cord-302215-sqrbj5r4 43 66 , , , cord-302215-sqrbj5r4 43 67 hydroxyzine hydroxyzine NN cord-302215-sqrbj5r4 43 68 , , , cord-302215-sqrbj5r4 43 69 domperidone domperidone NN cord-302215-sqrbj5r4 43 70 , , , cord-302215-sqrbj5r4 43 71 piperaquine piperaquine NNP cord-302215-sqrbj5r4 43 72 ) ) -RRB- cord-302215-sqrbj5r4 43 73 . . . cord-302215-sqrbj5r4 44 1 It -PRON- PRP cord-302215-sqrbj5r4 44 2 is be VBZ cord-302215-sqrbj5r4 44 3 noteworthy noteworthy JJ cord-302215-sqrbj5r4 44 4 that that IN cord-302215-sqrbj5r4 44 5 suffering suffering NN cord-302215-sqrbj5r4 44 6 of of IN cord-302215-sqrbj5r4 44 7 cardiac cardiac JJ cord-302215-sqrbj5r4 44 8 problems problem NNS cord-302215-sqrbj5r4 44 9 was be VBD cord-302215-sqrbj5r4 44 10 not not RB cord-302215-sqrbj5r4 44 11 a a DT cord-302215-sqrbj5r4 44 12 criterion criterion NN cord-302215-sqrbj5r4 44 13 of of IN cord-302215-sqrbj5r4 44 14 exclusion exclusion NN cord-302215-sqrbj5r4 44 15 from from IN cord-302215-sqrbj5r4 44 16 the the DT cord-302215-sqrbj5r4 44 17 study study NN cord-302215-sqrbj5r4 44 18 . . . cord-302215-sqrbj5r4 45 1 The the DT cord-302215-sqrbj5r4 45 2 estimated estimated JJ cord-302215-sqrbj5r4 45 3 study study NN cord-302215-sqrbj5r4 45 4 completion completion NN cord-302215-sqrbj5r4 45 5 date date NN cord-302215-sqrbj5r4 45 6 has have VBZ cord-302215-sqrbj5r4 45 7 been be VBN cord-302215-sqrbj5r4 45 8 fixed fix VBN cord-302215-sqrbj5r4 45 9 on on IN cord-302215-sqrbj5r4 45 10 March March NNP cord-302215-sqrbj5r4 45 11 2023 2023 CD cord-302215-sqrbj5r4 45 12 , , , cord-302215-sqrbj5r4 45 13 3 3 CD cord-302215-sqrbj5r4 45 14 years year NNS cord-302215-sqrbj5r4 45 15 after after IN cord-302215-sqrbj5r4 45 16 the the DT cord-302215-sqrbj5r4 45 17 starting start VBG cord-302215-sqrbj5r4 45 18 date date NN cord-302215-sqrbj5r4 45 19 . . . cord-302215-sqrbj5r4 46 1 Meanwhile meanwhile RB cord-302215-sqrbj5r4 46 2 , , , cord-302215-sqrbj5r4 46 3 some some DT cord-302215-sqrbj5r4 46 4 partial partial JJ cord-302215-sqrbj5r4 46 5 reports report NNS cord-302215-sqrbj5r4 46 6 on on IN cord-302215-sqrbj5r4 46 7 the the DT cord-302215-sqrbj5r4 46 8 efficacy efficacy NN cord-302215-sqrbj5r4 46 9 of of IN cord-302215-sqrbj5r4 46 10 those those DT cord-302215-sqrbj5r4 46 11 molecules molecule NNS cord-302215-sqrbj5r4 46 12 in in IN cord-302215-sqrbj5r4 46 13 the the DT cord-302215-sqrbj5r4 46 14 treatment treatment NN cord-302215-sqrbj5r4 46 15 of of IN cord-302215-sqrbj5r4 46 16 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 46 17 have have VBP cord-302215-sqrbj5r4 46 18 been be VBN cord-302215-sqrbj5r4 46 19 made make VBN cord-302215-sqrbj5r4 46 20 public public JJ cord-302215-sqrbj5r4 46 21 . . . cord-302215-sqrbj5r4 47 1 Their -PRON- PRP$ cord-302215-sqrbj5r4 47 2 conclusions conclusion NNS cord-302215-sqrbj5r4 47 3 are be VBP cord-302215-sqrbj5r4 47 4 often often RB cord-302215-sqrbj5r4 47 5 contradictory contradictory JJ cord-302215-sqrbj5r4 47 6 as as IN cord-302215-sqrbj5r4 47 7 reported report VBN cord-302215-sqrbj5r4 47 8 hereafter hereafter RB cord-302215-sqrbj5r4 47 9 . . . cord-302215-sqrbj5r4 47 10 _SP cord-302215-sqrbj5r4 48 1 Remdesivir Remdesivir NNP cord-302215-sqrbj5r4 48 2 ( ( -LRB- cord-302215-sqrbj5r4 48 3 GS-5734 GS-5734 NNP cord-302215-sqrbj5r4 48 4 ™ ™ LS cord-302215-sqrbj5r4 48 5 ) ) -RRB- cord-302215-sqrbj5r4 48 6 is be VBZ cord-302215-sqrbj5r4 48 7 an an DT cord-302215-sqrbj5r4 48 8 antiviral antiviral JJ cord-302215-sqrbj5r4 48 9 agent agent NN cord-302215-sqrbj5r4 48 10 developed develop VBN cord-302215-sqrbj5r4 48 11 by by IN cord-302215-sqrbj5r4 48 12 Gilead Gilead NNP cord-302215-sqrbj5r4 48 13 Sciences Sciences NNPS cord-302215-sqrbj5r4 48 14 in in IN cord-302215-sqrbj5r4 48 15 the the DT cord-302215-sqrbj5r4 48 16 frame frame NN cord-302215-sqrbj5r4 48 17 of of IN cord-302215-sqrbj5r4 48 18 the the DT cord-302215-sqrbj5r4 48 19 Ebola Ebola NNP cord-302215-sqrbj5r4 48 20 virus virus NN cord-302215-sqrbj5r4 48 21 outbreak outbreak NN cord-302215-sqrbj5r4 48 22 . . . cord-302215-sqrbj5r4 49 1 It -PRON- PRP cord-302215-sqrbj5r4 49 2 was be VBD cord-302215-sqrbj5r4 49 3 considered consider VBN cord-302215-sqrbj5r4 49 4 in in IN cord-302215-sqrbj5r4 49 5 one one CD cord-302215-sqrbj5r4 49 6 clinical clinical JJ cord-302215-sqrbj5r4 49 7 trial trial NN cord-302215-sqrbj5r4 49 8 only only RB cord-302215-sqrbj5r4 49 9 on on IN cord-302215-sqrbj5r4 49 10 the the DT cord-302215-sqrbj5r4 49 11 subject subject NN cord-302215-sqrbj5r4 49 12 : : : cord-302215-sqrbj5r4 49 13 " " `` cord-302215-sqrbj5r4 49 14 Investigational Investigational NNP cord-302215-sqrbj5r4 49 15 Therapeutics Therapeutics NNPS cord-302215-sqrbj5r4 49 16 for for IN cord-302215-sqrbj5r4 49 17 the the DT cord-302215-sqrbj5r4 49 18 Treatment Treatment NNP cord-302215-sqrbj5r4 49 19 of of IN cord-302215-sqrbj5r4 49 20 People People NNPS cord-302215-sqrbj5r4 49 21 with with IN cord-302215-sqrbj5r4 49 22 Ebola Ebola NNP cord-302215-sqrbj5r4 49 23 Virus Virus NNP cord-302215-sqrbj5r4 49 24 Disease Disease NNP cord-302215-sqrbj5r4 49 25 " " '' cord-302215-sqrbj5r4 49 26 ( ( -LRB- cord-302215-sqrbj5r4 49 27 NCT03719586 NCT03719586 NNP cord-302215-sqrbj5r4 49 28 ) ) -RRB- cord-302215-sqrbj5r4 49 29 . . . cord-302215-sqrbj5r4 50 1 [ [ -LRB- cord-302215-sqrbj5r4 50 2 8 8 CD cord-302215-sqrbj5r4 50 3 ] ] -RRB- cord-302215-sqrbj5r4 51 1 The the DT cord-302215-sqrbj5r4 51 2 study study NN cord-302215-sqrbj5r4 51 3 was be VBD cord-302215-sqrbj5r4 51 4 interrupted interrupt VBN cord-302215-sqrbj5r4 51 5 because because IN cord-302215-sqrbj5r4 51 6 the the DT cord-302215-sqrbj5r4 51 7 number number NN cord-302215-sqrbj5r4 51 8 of of IN cord-302215-sqrbj5r4 51 9 deaths death NNS cord-302215-sqrbj5r4 51 10 in in IN cord-302215-sqrbj5r4 51 11 the the DT cord-302215-sqrbj5r4 51 12 group group NN cord-302215-sqrbj5r4 51 13 receiving receive VBG cord-302215-sqrbj5r4 51 14 remdesivir remdesivir NNP cord-302215-sqrbj5r4 51 15 was be VBD cord-302215-sqrbj5r4 51 16 higher high JJR cord-302215-sqrbj5r4 51 17 than than IN cord-302215-sqrbj5r4 51 18 in in IN cord-302215-sqrbj5r4 51 19 the the DT cord-302215-sqrbj5r4 51 20 control control NN cord-302215-sqrbj5r4 51 21 group group NN cord-302215-sqrbj5r4 51 22 [ [ -LRB- cord-302215-sqrbj5r4 51 23 9 9 CD cord-302215-sqrbj5r4 51 24 ] ] -RRB- cord-302215-sqrbj5r4 51 25 . . . cord-302215-sqrbj5r4 52 1 The the DT cord-302215-sqrbj5r4 52 2 molecule molecule NN cord-302215-sqrbj5r4 52 3 was be VBD cord-302215-sqrbj5r4 52 4 designated designate VBN cord-302215-sqrbj5r4 52 5 as as IN cord-302215-sqrbj5r4 52 6 an an DT cord-302215-sqrbj5r4 52 7 orphan orphan NN cord-302215-sqrbj5r4 52 8 drug drug NN cord-302215-sqrbj5r4 52 9 for for IN cord-302215-sqrbj5r4 52 10 treatment treatment NN cord-302215-sqrbj5r4 52 11 of of IN cord-302215-sqrbj5r4 52 12 Ebola Ebola NNP cord-302215-sqrbj5r4 52 13 disease disease NN cord-302215-sqrbj5r4 52 14 on on IN cord-302215-sqrbj5r4 52 15 September September NNP cord-302215-sqrbj5r4 52 16 18 18 CD cord-302215-sqrbj5r4 52 17 , , , cord-302215-sqrbj5r4 52 18 2015 2015 CD cord-302215-sqrbj5r4 52 19 [ [ -LRB- cord-302215-sqrbj5r4 52 20 10 10 CD cord-302215-sqrbj5r4 52 21 ] ] -RRB- cord-302215-sqrbj5r4 52 22 . . . cord-302215-sqrbj5r4 53 1 Gilead Gilead NNP cord-302215-sqrbj5r4 53 2 was be VBD cord-302215-sqrbj5r4 53 3 also also RB cord-302215-sqrbj5r4 53 4 granted grant VBN cord-302215-sqrbj5r4 53 5 the the DT cord-302215-sqrbj5r4 53 6 orphan orphan NN cord-302215-sqrbj5r4 53 7 drug drug NN cord-302215-sqrbj5r4 53 8 designation designation NN cord-302215-sqrbj5r4 53 9 for for IN cord-302215-sqrbj5r4 53 10 treatment treatment NN cord-302215-sqrbj5r4 53 11 of of IN cord-302215-sqrbj5r4 53 12 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 53 13 in in IN cord-302215-sqrbj5r4 53 14 March March NNP cord-302215-sqrbj5r4 53 15 23 23 CD cord-302215-sqrbj5r4 53 16 , , , cord-302215-sqrbj5r4 53 17 2020 2020 CD cord-302215-sqrbj5r4 53 18 . . . cord-302215-sqrbj5r4 54 1 [ [ -LRB- cord-302215-sqrbj5r4 54 2 11 11 CD cord-302215-sqrbj5r4 54 3 ] ] -RRB- cord-302215-sqrbj5r4 55 1 However however RB cord-302215-sqrbj5r4 55 2 , , , cord-302215-sqrbj5r4 55 3 2 2 CD cord-302215-sqrbj5r4 55 4 days day NNS cord-302215-sqrbj5r4 55 5 later later RB cord-302215-sqrbj5r4 55 6 , , , cord-302215-sqrbj5r4 55 7 under under IN cord-302215-sqrbj5r4 55 8 an an DT cord-302215-sqrbj5r4 55 9 explosion explosion NN cord-302215-sqrbj5r4 55 10 of of IN cord-302215-sqrbj5r4 55 11 criticisms criticism NNS cord-302215-sqrbj5r4 55 12 , , , cord-302215-sqrbj5r4 55 13 the the DT cord-302215-sqrbj5r4 55 14 _SP cord-302215-sqrbj5r4 55 15 Remdesivir Remdesivir NNP cord-302215-sqrbj5r4 55 16 ( ( -LRB- cord-302215-sqrbj5r4 55 17 GS-5734 GS-5734 NNP cord-302215-sqrbj5r4 55 18 ™ ™ LS cord-302215-sqrbj5r4 55 19 ) ) -RRB- cord-302215-sqrbj5r4 55 20 is be VBZ cord-302215-sqrbj5r4 55 21 an an DT cord-302215-sqrbj5r4 55 22 antiviral antiviral JJ cord-302215-sqrbj5r4 55 23 agent agent NN cord-302215-sqrbj5r4 55 24 developed develop VBN cord-302215-sqrbj5r4 55 25 by by IN cord-302215-sqrbj5r4 55 26 Gilead Gilead NNP cord-302215-sqrbj5r4 55 27 Sciences Sciences NNPS cord-302215-sqrbj5r4 55 28 in in IN cord-302215-sqrbj5r4 55 29 the the DT cord-302215-sqrbj5r4 55 30 frame frame NN cord-302215-sqrbj5r4 55 31 of of IN cord-302215-sqrbj5r4 55 32 the the DT cord-302215-sqrbj5r4 55 33 Ebola Ebola NNP cord-302215-sqrbj5r4 55 34 virus virus NN cord-302215-sqrbj5r4 55 35 outbreak outbreak NN cord-302215-sqrbj5r4 55 36 . . . cord-302215-sqrbj5r4 56 1 It -PRON- PRP cord-302215-sqrbj5r4 56 2 was be VBD cord-302215-sqrbj5r4 56 3 considered consider VBN cord-302215-sqrbj5r4 56 4 in in IN cord-302215-sqrbj5r4 56 5 one one CD cord-302215-sqrbj5r4 56 6 clinical clinical JJ cord-302215-sqrbj5r4 56 7 trial trial NN cord-302215-sqrbj5r4 56 8 only only RB cord-302215-sqrbj5r4 56 9 on on IN cord-302215-sqrbj5r4 56 10 the the DT cord-302215-sqrbj5r4 56 11 subject subject NN cord-302215-sqrbj5r4 56 12 : : : cord-302215-sqrbj5r4 56 13 " " `` cord-302215-sqrbj5r4 56 14 Investigational Investigational NNP cord-302215-sqrbj5r4 56 15 Therapeutics Therapeutics NNPS cord-302215-sqrbj5r4 56 16 for for IN cord-302215-sqrbj5r4 56 17 the the DT cord-302215-sqrbj5r4 56 18 Treatment Treatment NNP cord-302215-sqrbj5r4 56 19 of of IN cord-302215-sqrbj5r4 56 20 People People NNPS cord-302215-sqrbj5r4 56 21 with with IN cord-302215-sqrbj5r4 56 22 Ebola Ebola NNP cord-302215-sqrbj5r4 56 23 Virus Virus NNP cord-302215-sqrbj5r4 56 24 Disease Disease NNP cord-302215-sqrbj5r4 56 25 " " '' cord-302215-sqrbj5r4 56 26 ( ( -LRB- cord-302215-sqrbj5r4 56 27 NCT03719586 NCT03719586 NNP cord-302215-sqrbj5r4 56 28 ) ) -RRB- cord-302215-sqrbj5r4 56 29 . . . cord-302215-sqrbj5r4 57 1 [ [ -LRB- cord-302215-sqrbj5r4 57 2 8 8 CD cord-302215-sqrbj5r4 57 3 ] ] -RRB- cord-302215-sqrbj5r4 58 1 The the DT cord-302215-sqrbj5r4 58 2 study study NN cord-302215-sqrbj5r4 58 3 was be VBD cord-302215-sqrbj5r4 58 4 interrupted interrupt VBN cord-302215-sqrbj5r4 58 5 because because IN cord-302215-sqrbj5r4 58 6 the the DT cord-302215-sqrbj5r4 58 7 number number NN cord-302215-sqrbj5r4 58 8 of of IN cord-302215-sqrbj5r4 58 9 deaths death NNS cord-302215-sqrbj5r4 58 10 in in IN cord-302215-sqrbj5r4 58 11 the the DT cord-302215-sqrbj5r4 58 12 group group NN cord-302215-sqrbj5r4 58 13 receiving receive VBG cord-302215-sqrbj5r4 58 14 remdesivir remdesivir NNP cord-302215-sqrbj5r4 58 15 was be VBD cord-302215-sqrbj5r4 58 16 higher high JJR cord-302215-sqrbj5r4 58 17 than than IN cord-302215-sqrbj5r4 58 18 in in IN cord-302215-sqrbj5r4 58 19 the the DT cord-302215-sqrbj5r4 58 20 control control NN cord-302215-sqrbj5r4 58 21 group group NN cord-302215-sqrbj5r4 58 22 [ [ -LRB- cord-302215-sqrbj5r4 58 23 9 9 CD cord-302215-sqrbj5r4 58 24 ] ] -RRB- cord-302215-sqrbj5r4 58 25 . . . cord-302215-sqrbj5r4 59 1 The the DT cord-302215-sqrbj5r4 59 2 molecule molecule NN cord-302215-sqrbj5r4 59 3 was be VBD cord-302215-sqrbj5r4 59 4 designated designate VBN cord-302215-sqrbj5r4 59 5 as as IN cord-302215-sqrbj5r4 59 6 an an DT cord-302215-sqrbj5r4 59 7 orphan orphan NN cord-302215-sqrbj5r4 59 8 drug drug NN cord-302215-sqrbj5r4 59 9 for for IN cord-302215-sqrbj5r4 59 10 treatment treatment NN cord-302215-sqrbj5r4 59 11 of of IN cord-302215-sqrbj5r4 59 12 Ebola Ebola NNP cord-302215-sqrbj5r4 59 13 disease disease NN cord-302215-sqrbj5r4 59 14 on on IN cord-302215-sqrbj5r4 59 15 September September NNP cord-302215-sqrbj5r4 59 16 18 18 CD cord-302215-sqrbj5r4 59 17 , , , cord-302215-sqrbj5r4 59 18 2015 2015 CD cord-302215-sqrbj5r4 59 19 [ [ -LRB- cord-302215-sqrbj5r4 59 20 10 10 CD cord-302215-sqrbj5r4 59 21 ] ] -RRB- cord-302215-sqrbj5r4 59 22 . . . cord-302215-sqrbj5r4 60 1 Gilead Gilead NNP cord-302215-sqrbj5r4 60 2 was be VBD cord-302215-sqrbj5r4 60 3 also also RB cord-302215-sqrbj5r4 60 4 granted grant VBN cord-302215-sqrbj5r4 60 5 the the DT cord-302215-sqrbj5r4 60 6 orphan orphan NN cord-302215-sqrbj5r4 60 7 drug drug NN cord-302215-sqrbj5r4 60 8 designation designation NN cord-302215-sqrbj5r4 60 9 for for IN cord-302215-sqrbj5r4 60 10 treatment treatment NN cord-302215-sqrbj5r4 60 11 of of IN cord-302215-sqrbj5r4 60 12 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 60 13 in in IN cord-302215-sqrbj5r4 60 14 March March NNP cord-302215-sqrbj5r4 60 15 23 23 CD cord-302215-sqrbj5r4 60 16 , , , cord-302215-sqrbj5r4 60 17 2020 2020 CD cord-302215-sqrbj5r4 60 18 . . . cord-302215-sqrbj5r4 61 1 [ [ -LRB- cord-302215-sqrbj5r4 61 2 11 11 CD cord-302215-sqrbj5r4 61 3 ] ] -RRB- cord-302215-sqrbj5r4 62 1 However however RB cord-302215-sqrbj5r4 62 2 , , , cord-302215-sqrbj5r4 62 3 2 2 CD cord-302215-sqrbj5r4 62 4 days day NNS cord-302215-sqrbj5r4 62 5 later later RB cord-302215-sqrbj5r4 62 6 , , , cord-302215-sqrbj5r4 62 7 under under IN cord-302215-sqrbj5r4 62 8 an an DT cord-302215-sqrbj5r4 62 9 explosion explosion NN cord-302215-sqrbj5r4 62 10 of of IN cord-302215-sqrbj5r4 62 11 criticisms criticism NNS cord-302215-sqrbj5r4 62 12 , , , cord-302215-sqrbj5r4 62 13 the the DT cord-302215-sqrbj5r4 62 14 company company NN cord-302215-sqrbj5r4 62 15 asked ask VBD cord-302215-sqrbj5r4 62 16 for for IN cord-302215-sqrbj5r4 62 17 a a DT cord-302215-sqrbj5r4 62 18 cancellation cancellation NN cord-302215-sqrbj5r4 62 19 of of IN cord-302215-sqrbj5r4 62 20 its -PRON- PRP$ cord-302215-sqrbj5r4 62 21 designation designation NN cord-302215-sqrbj5r4 62 22 [ [ -LRB- cord-302215-sqrbj5r4 62 23 12 12 CD cord-302215-sqrbj5r4 62 24 ] ] -RRB- cord-302215-sqrbj5r4 62 25 . . . cord-302215-sqrbj5r4 63 1 Access access NN cord-302215-sqrbj5r4 63 2 to to IN cord-302215-sqrbj5r4 63 3 the the DT cord-302215-sqrbj5r4 63 4 drug drug NN cord-302215-sqrbj5r4 63 5 has have VBZ cord-302215-sqrbj5r4 63 6 also also RB cord-302215-sqrbj5r4 63 7 been be VBN cord-302215-sqrbj5r4 63 8 expanded expand VBN cord-302215-sqrbj5r4 63 9 , , , cord-302215-sqrbj5r4 63 10 exceptionally exceptionally RB cord-302215-sqrbj5r4 63 11 , , , cord-302215-sqrbj5r4 63 12 to to IN cord-302215-sqrbj5r4 63 13 the the DT cord-302215-sqrbj5r4 63 14 US US NNP cord-302215-sqrbj5r4 63 15 army army NN cord-302215-sqrbj5r4 63 16 [ [ -LRB- cord-302215-sqrbj5r4 63 17 13 13 CD cord-302215-sqrbj5r4 63 18 ] ] -RRB- cord-302215-sqrbj5r4 63 19 . . . cord-302215-sqrbj5r4 64 1 The the DT cord-302215-sqrbj5r4 64 2 first first JJ cord-302215-sqrbj5r4 64 3 patient patient NN cord-302215-sqrbj5r4 64 4 infected infect VBN cord-302215-sqrbj5r4 64 5 by by IN cord-302215-sqrbj5r4 64 6 SARS SARS NNP cord-302215-sqrbj5r4 64 7 - - HYPH cord-302215-sqrbj5r4 64 8 CoV-2 CoV-2 NNP cord-302215-sqrbj5r4 64 9 in in IN cord-302215-sqrbj5r4 64 10 the the DT cord-302215-sqrbj5r4 64 11 United United NNP cord-302215-sqrbj5r4 64 12 States States NNP cord-302215-sqrbj5r4 64 13 was be VBD cord-302215-sqrbj5r4 64 14 hospitalized hospitalize VBN cord-302215-sqrbj5r4 64 15 on on IN cord-302215-sqrbj5r4 64 16 January January NNP cord-302215-sqrbj5r4 64 17 19 19 CD cord-302215-sqrbj5r4 64 18 and and CC cord-302215-sqrbj5r4 64 19 treated treat VBN cord-302215-sqrbj5r4 64 20 with with IN cord-302215-sqrbj5r4 64 21 compassionate compassionate JJ cord-302215-sqrbj5r4 64 22 - - HYPH cord-302215-sqrbj5r4 64 23 use use NN cord-302215-sqrbj5r4 64 24 remdesivir remdesivir NNS cord-302215-sqrbj5r4 64 25 . . . cord-302215-sqrbj5r4 65 1 [ [ -LRB- cord-302215-sqrbj5r4 65 2 14 14 CD cord-302215-sqrbj5r4 65 3 ] ] -RRB- cord-302215-sqrbj5r4 66 1 The the DT cord-302215-sqrbj5r4 66 2 authors author NNS cord-302215-sqrbj5r4 66 3 concluded conclude VBD cord-302215-sqrbj5r4 66 4 : : : cord-302215-sqrbj5r4 66 5 " " `` cord-302215-sqrbj5r4 66 6 . . . cord-302215-sqrbj5r4 66 7 . . . cord-302215-sqrbj5r4 66 8 . . . cord-302215-sqrbj5r4 67 1 As as IN cord-302215-sqrbj5r4 67 2 of of IN cord-302215-sqrbj5r4 67 3 January January NNP cord-302215-sqrbj5r4 67 4 30 30 CD cord-302215-sqrbj5r4 67 5 , , , cord-302215-sqrbj5r4 67 6 2020 2020 CD cord-302215-sqrbj5r4 67 7 , , , cord-302215-sqrbj5r4 67 8 the the DT cord-302215-sqrbj5r4 67 9 patient patient NN cord-302215-sqrbj5r4 67 10 remains remain VBZ cord-302215-sqrbj5r4 67 11 hospitalized hospitalize VBN cord-302215-sqrbj5r4 67 12 . . . cord-302215-sqrbj5r4 68 1 He -PRON- PRP cord-302215-sqrbj5r4 68 2 is be VBZ cord-302215-sqrbj5r4 68 3 afebrile afebrile JJ cord-302215-sqrbj5r4 68 4 , , , cord-302215-sqrbj5r4 68 5 and and CC cord-302215-sqrbj5r4 68 6 all all DT cord-302215-sqrbj5r4 68 7 symptoms symptom NNS cord-302215-sqrbj5r4 68 8 have have VBP cord-302215-sqrbj5r4 68 9 resolved resolve VBN cord-302215-sqrbj5r4 68 10 with with IN cord-302215-sqrbj5r4 68 11 the the DT cord-302215-sqrbj5r4 68 12 exception exception NN cord-302215-sqrbj5r4 68 13 of of IN cord-302215-sqrbj5r4 68 14 his -PRON- PRP$ cord-302215-sqrbj5r4 68 15 cough cough NN cord-302215-sqrbj5r4 68 16 , , , cord-302215-sqrbj5r4 68 17 which which WDT cord-302215-sqrbj5r4 68 18 is be VBZ cord-302215-sqrbj5r4 68 19 decreasing decrease VBG cord-302215-sqrbj5r4 68 20 in in IN cord-302215-sqrbj5r4 68 21 severity severity NN cord-302215-sqrbj5r4 68 22 . . . cord-302215-sqrbj5r4 68 23 . . . cord-302215-sqrbj5r4 68 24 . . . cord-302215-sqrbj5r4 68 25 . . . cord-302215-sqrbj5r4 69 1 Although although IN cord-302215-sqrbj5r4 69 2 a a DT cord-302215-sqrbj5r4 69 3 decision decision NN cord-302215-sqrbj5r4 69 4 to to TO cord-302215-sqrbj5r4 69 5 administer administer VB cord-302215-sqrbj5r4 69 6 remdesivir remdesivir NNP cord-302215-sqrbj5r4 69 7 for for IN cord-302215-sqrbj5r4 69 8 compassionate compassionate JJ cord-302215-sqrbj5r4 69 9 use use NN cord-302215-sqrbj5r4 69 10 was be VBD cord-302215-sqrbj5r4 69 11 based base VBN cord-302215-sqrbj5r4 69 12 on on IN cord-302215-sqrbj5r4 69 13 the the DT cord-302215-sqrbj5r4 69 14 case case NN cord-302215-sqrbj5r4 69 15 patient patient NN cord-302215-sqrbj5r4 69 16 's 's POS cord-302215-sqrbj5r4 69 17 worsening worsen VBG cord-302215-sqrbj5r4 69 18 clinical clinical JJ cord-302215-sqrbj5r4 69 19 status status NN cord-302215-sqrbj5r4 69 20 , , , cord-302215-sqrbj5r4 69 21 randomized randomized JJ cord-302215-sqrbj5r4 69 22 controlled control VBN cord-302215-sqrbj5r4 69 23 trials trial NNS cord-302215-sqrbj5r4 69 24 are be VBP cord-302215-sqrbj5r4 69 25 needed need VBN cord-302215-sqrbj5r4 69 26 to to TO cord-302215-sqrbj5r4 69 27 determine determine VB cord-302215-sqrbj5r4 69 28 the the DT cord-302215-sqrbj5r4 69 29 safety safety NN cord-302215-sqrbj5r4 69 30 and and CC cord-302215-sqrbj5r4 69 31 efficacy efficacy NN cord-302215-sqrbj5r4 69 32 of of IN cord-302215-sqrbj5r4 69 33 remdesivir remdesivir NNP cord-302215-sqrbj5r4 69 34 and and CC cord-302215-sqrbj5r4 69 35 any any DT cord-302215-sqrbj5r4 69 36 other other JJ cord-302215-sqrbj5r4 69 37 investigational investigational JJ cord-302215-sqrbj5r4 69 38 agents agent NNS cord-302215-sqrbj5r4 69 39 for for IN cord-302215-sqrbj5r4 69 40 treatment treatment NN cord-302215-sqrbj5r4 69 41 of of IN cord-302215-sqrbj5r4 69 42 patients patient NNS cord-302215-sqrbj5r4 69 43 with with IN cord-302215-sqrbj5r4 69 44 2019-nCoV 2019-ncov CD cord-302215-sqrbj5r4 69 45 infection infection NN cord-302215-sqrbj5r4 69 46 . . . cord-302215-sqrbj5r4 70 1 " " `` cord-302215-sqrbj5r4 70 2 At at IN cord-302215-sqrbj5r4 70 3 the the DT cord-302215-sqrbj5r4 70 4 end end NN cord-302215-sqrbj5r4 70 5 of of IN cord-302215-sqrbj5r4 70 6 January January NNP cord-302215-sqrbj5r4 70 7 , , , cord-302215-sqrbj5r4 70 8 Gilead Gilead NNP cord-302215-sqrbj5r4 70 9 accepted accept VBD cord-302215-sqrbj5r4 70 10 to to TO cord-302215-sqrbj5r4 70 11 provide provide VB cord-302215-sqrbj5r4 70 12 remdesivir remdesivir NNS cord-302215-sqrbj5r4 70 13 for for IN cord-302215-sqrbj5r4 70 14 compassionate compassionate JJ cord-302215-sqrbj5r4 70 15 - - HYPH cord-302215-sqrbj5r4 70 16 use use NN cord-302215-sqrbj5r4 70 17 to to IN cord-302215-sqrbj5r4 70 18 a a DT cord-302215-sqrbj5r4 70 19 series series NN cord-302215-sqrbj5r4 70 20 of of IN cord-302215-sqrbj5r4 70 21 clinicians clinician NNS cord-302215-sqrbj5r4 70 22 in in IN cord-302215-sqrbj5r4 70 23 Austria Austria NNP cord-302215-sqrbj5r4 70 24 , , , cord-302215-sqrbj5r4 70 25 Canada Canada NNP cord-302215-sqrbj5r4 70 26 , , , cord-302215-sqrbj5r4 70 27 France France NNP cord-302215-sqrbj5r4 70 28 , , , cord-302215-sqrbj5r4 70 29 Germany Germany NNP cord-302215-sqrbj5r4 70 30 , , , cord-302215-sqrbj5r4 70 31 Italy Italy NNP cord-302215-sqrbj5r4 70 32 , , , cord-302215-sqrbj5r4 70 33 Japan Japan NNP cord-302215-sqrbj5r4 70 34 , , , cord-302215-sqrbj5r4 70 35 the the DT cord-302215-sqrbj5r4 70 36 Netherlands Netherlands NNP cord-302215-sqrbj5r4 70 37 , , , cord-302215-sqrbj5r4 70 38 Spain Spain NNP cord-302215-sqrbj5r4 70 39 , , , cord-302215-sqrbj5r4 70 40 and and CC cord-302215-sqrbj5r4 70 41 the the DT cord-302215-sqrbj5r4 70 42 United United NNP cord-302215-sqrbj5r4 70 43 States States NNP cord-302215-sqrbj5r4 70 44 . . . cord-302215-sqrbj5r4 71 1 The the DT cord-302215-sqrbj5r4 71 2 authors author NNS cord-302215-sqrbj5r4 71 3 of of IN cord-302215-sqrbj5r4 71 4 the the DT cord-302215-sqrbj5r4 71 5 study study NN cord-302215-sqrbj5r4 71 6 concluded conclude VBD cord-302215-sqrbj5r4 71 7 that that IN cord-302215-sqrbj5r4 71 8 " " `` cord-302215-sqrbj5r4 71 9 In in IN cord-302215-sqrbj5r4 71 10 this this DT cord-302215-sqrbj5r4 71 11 cohort cohort NN cord-302215-sqrbj5r4 71 12 of of IN cord-302215-sqrbj5r4 71 13 ( ( -LRB- cord-302215-sqrbj5r4 71 14 53 53 CD cord-302215-sqrbj5r4 71 15 ) ) -RRB- cord-302215-sqrbj5r4 71 16 patients patient NNS cord-302215-sqrbj5r4 71 17 hospitalized hospitalize VBN cord-302215-sqrbj5r4 71 18 for for IN cord-302215-sqrbj5r4 71 19 severe severe JJ cord-302215-sqrbj5r4 71 20 Covid-19 covid-19 NN cord-302215-sqrbj5r4 71 21 , , , cord-302215-sqrbj5r4 71 22 clinical clinical JJ cord-302215-sqrbj5r4 71 23 improvement improvement NN cord-302215-sqrbj5r4 71 24 was be VBD cord-302215-sqrbj5r4 71 25 observed observe VBN cord-302215-sqrbj5r4 71 26 in in IN cord-302215-sqrbj5r4 71 27 36 36 CD cord-302215-sqrbj5r4 71 28 of of IN cord-302215-sqrbj5r4 71 29 53 53 CD cord-302215-sqrbj5r4 71 30 patients patient NNS cord-302215-sqrbj5r4 71 31 ( ( -LRB- cord-302215-sqrbj5r4 71 32 68 68 CD cord-302215-sqrbj5r4 71 33 % % NN cord-302215-sqrbj5r4 71 34 ) ) -RRB- cord-302215-sqrbj5r4 71 35 . . . cord-302215-sqrbj5r4 72 1 Measurement measurement NN cord-302215-sqrbj5r4 72 2 of of IN cord-302215-sqrbj5r4 72 3 efficacy efficacy NN cord-302215-sqrbj5r4 72 4 will will MD cord-302215-sqrbj5r4 72 5 require require VB cord-302215-sqrbj5r4 72 6 ongoing ongoing JJ cord-302215-sqrbj5r4 72 7 randomized randomized JJ cord-302215-sqrbj5r4 72 8 , , , cord-302215-sqrbj5r4 72 9 placebo placebo NN cord-302215-sqrbj5r4 72 10 - - HYPH cord-302215-sqrbj5r4 72 11 controlled control VBN cord-302215-sqrbj5r4 72 12 trials trial NNS cord-302215-sqrbj5r4 72 13 of of IN cord-302215-sqrbj5r4 72 14 remdesivir remdesivir NNP cord-302215-sqrbj5r4 72 15 therapy therapy NN cord-302215-sqrbj5r4 72 16 . . . cord-302215-sqrbj5r4 72 17 " " '' cord-302215-sqrbj5r4 73 1 [ [ -LRB- cord-302215-sqrbj5r4 73 2 15 15 CD cord-302215-sqrbj5r4 73 3 ] ] -RRB- cord-302215-sqrbj5r4 73 4 Gilead Gilead NNP cord-302215-sqrbj5r4 73 5 has have VBZ cord-302215-sqrbj5r4 73 6 extended extend VBN cord-302215-sqrbj5r4 73 7 the the DT cord-302215-sqrbj5r4 73 8 research research NN cord-302215-sqrbj5r4 73 9 ( ( -LRB- cord-302215-sqrbj5r4 73 10 NCT04323761 NCT04323761 NNP cord-302215-sqrbj5r4 73 11 [ [ -LRB- cord-302215-sqrbj5r4 73 12 16 16 CD cord-302215-sqrbj5r4 73 13 ] ] -RRB- cord-302215-sqrbj5r4 73 14 ) ) -RRB- cord-302215-sqrbj5r4 73 15 by by IN cord-302215-sqrbj5r4 73 16 providing provide VBG cord-302215-sqrbj5r4 73 17 intravenous intravenous JJ cord-302215-sqrbj5r4 73 18 infusions infusion NNS cord-302215-sqrbj5r4 73 19 of of IN cord-302215-sqrbj5r4 73 20 remdesivir remdesivir NNS cord-302215-sqrbj5r4 73 21 to to IN cord-302215-sqrbj5r4 73 22 155 155 CD cord-302215-sqrbj5r4 73 23 hospitals hospital NNS cord-302215-sqrbj5r4 73 24 in in IN cord-302215-sqrbj5r4 73 25 12 12 CD cord-302215-sqrbj5r4 73 26 countries country NNS cord-302215-sqrbj5r4 73 27 : : : cord-302215-sqrbj5r4 73 28 Belgium Belgium NNP cord-302215-sqrbj5r4 73 29 ( ( -LRB- cord-302215-sqrbj5r4 73 30 4 4 CD cord-302215-sqrbj5r4 73 31 hospitals hospital NNS cord-302215-sqrbj5r4 73 32 ) ) -RRB- cord-302215-sqrbj5r4 73 33 , , , cord-302215-sqrbj5r4 73 34 Canada Canada NNP cord-302215-sqrbj5r4 73 35 ( ( -LRB- cord-302215-sqrbj5r4 73 36 1 1 CD cord-302215-sqrbj5r4 73 37 ) ) -RRB- cord-302215-sqrbj5r4 73 38 , , , cord-302215-sqrbj5r4 73 39 France France NNP cord-302215-sqrbj5r4 73 40 ( ( -LRB- cord-302215-sqrbj5r4 73 41 9 9 CD cord-302215-sqrbj5r4 73 42 ) ) -RRB- cord-302215-sqrbj5r4 73 43 , , , cord-302215-sqrbj5r4 73 44 Germany Germany NNP cord-302215-sqrbj5r4 73 45 ( ( -LRB- cord-302215-sqrbj5r4 73 46 7 7 CD cord-302215-sqrbj5r4 73 47 ) ) -RRB- cord-302215-sqrbj5r4 73 48 , , , cord-302215-sqrbj5r4 73 49 Israel Israel NNP cord-302215-sqrbj5r4 73 50 ( ( -LRB- cord-302215-sqrbj5r4 73 51 3),Italy 3),italy CD cord-302215-sqrbj5r4 73 52 ( ( -LRB- cord-302215-sqrbj5r4 73 53 7 7 CD cord-302215-sqrbj5r4 73 54 ) ) -RRB- cord-302215-sqrbj5r4 73 55 , , , cord-302215-sqrbj5r4 73 56 Netherlands Netherlands NNP cord-302215-sqrbj5r4 73 57 ( ( -LRB- cord-302215-sqrbj5r4 73 58 2 2 CD cord-302215-sqrbj5r4 73 59 ) ) -RRB- cord-302215-sqrbj5r4 73 60 , , , cord-302215-sqrbj5r4 73 61 Romania Romania NNP cord-302215-sqrbj5r4 73 62 ( ( -LRB- cord-302215-sqrbj5r4 73 63 1 1 CD cord-302215-sqrbj5r4 73 64 ) ) -RRB- cord-302215-sqrbj5r4 73 65 , , , cord-302215-sqrbj5r4 73 66 Spain Spain NNP cord-302215-sqrbj5r4 73 67 ( ( -LRB- cord-302215-sqrbj5r4 73 68 10 10 CD cord-302215-sqrbj5r4 73 69 ) ) -RRB- cord-302215-sqrbj5r4 73 70 , , , cord-302215-sqrbj5r4 73 71 Switzerland Switzerland NNP cord-302215-sqrbj5r4 73 72 ( ( -LRB- cord-302215-sqrbj5r4 73 73 6 6 CD cord-302215-sqrbj5r4 73 74 ) ) -RRB- cord-302215-sqrbj5r4 73 75 , , , cord-302215-sqrbj5r4 73 76 the the DT cord-302215-sqrbj5r4 73 77 United United NNP cord-302215-sqrbj5r4 73 78 Kingdom Kingdom NNP cord-302215-sqrbj5r4 73 79 ( ( -LRB- cord-302215-sqrbj5r4 73 80 4 4 CD cord-302215-sqrbj5r4 73 81 ) ) -RRB- cord-302215-sqrbj5r4 73 82 , , , cord-302215-sqrbj5r4 73 83 and and CC cord-302215-sqrbj5r4 73 84 the the DT cord-302215-sqrbj5r4 73 85 United United NNP cord-302215-sqrbj5r4 73 86 States States NNP cord-302215-sqrbj5r4 73 87 ( ( -LRB- cord-302215-sqrbj5r4 73 88 101 101 CD cord-302215-sqrbj5r4 73 89 ) ) -RRB- cord-302215-sqrbj5r4 73 90 . . . cord-302215-sqrbj5r4 74 1 In in IN cord-302215-sqrbj5r4 74 2 a a DT cord-302215-sqrbj5r4 74 3 press press NN cord-302215-sqrbj5r4 74 4 release release NN cord-302215-sqrbj5r4 74 5 , , , cord-302215-sqrbj5r4 74 6 on on IN cord-302215-sqrbj5r4 74 7 April April NNP cord-302215-sqrbj5r4 74 8 16 16 CD cord-302215-sqrbj5r4 74 9 , , , cord-302215-sqrbj5r4 74 10 K. K. NNP cord-302215-sqrbj5r4 74 11 Mullane Mullane NNP cord-302215-sqrbj5r4 74 12 , , , cord-302215-sqrbj5r4 74 13 from from IN cord-302215-sqrbj5r4 74 14 the the DT cord-302215-sqrbj5r4 74 15 university university NN cord-302215-sqrbj5r4 74 16 of of IN cord-302215-sqrbj5r4 74 17 Chicago Chicago NNP cord-302215-sqrbj5r4 74 18 announced announce VBD cord-302215-sqrbj5r4 74 19 that that IN cord-302215-sqrbj5r4 74 20 125 125 CD cord-302215-sqrbj5r4 74 21 patients patient NNS cord-302215-sqrbj5r4 74 22 , , , cord-302215-sqrbj5r4 74 23 mostly mostly RB cord-302215-sqrbj5r4 74 24 with with IN cord-302215-sqrbj5r4 74 25 severe severe JJ cord-302215-sqrbj5r4 74 26 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 74 27 , , , cord-302215-sqrbj5r4 74 28 had have VBD cord-302215-sqrbj5r4 74 29 entered enter VBN cord-302215-sqrbj5r4 74 30 into into IN cord-302215-sqrbj5r4 74 31 the the DT cord-302215-sqrbj5r4 74 32 phase phase NN cord-302215-sqrbj5r4 74 33 3 3 CD cord-302215-sqrbj5r4 74 34 trial trial NN cord-302215-sqrbj5r4 74 35 and and CC cord-302215-sqrbj5r4 74 36 she -PRON- PRP cord-302215-sqrbj5r4 74 37 concluded conclude VBD cord-302215-sqrbj5r4 74 38 that that IN cord-302215-sqrbj5r4 74 39 " " `` cord-302215-sqrbj5r4 74 40 the the DT cord-302215-sqrbj5r4 74 41 best good JJS cord-302215-sqrbj5r4 74 42 news news NN cord-302215-sqrbj5r4 74 43 is be VBZ cord-302215-sqrbj5r4 74 44 that that IN cord-302215-sqrbj5r4 74 45 most most JJS cord-302215-sqrbj5r4 74 46 of of IN cord-302215-sqrbj5r4 74 47 our -PRON- PRP$ cord-302215-sqrbj5r4 74 48 patients patient NNS cord-302215-sqrbj5r4 74 49 have have VBP cord-302215-sqrbj5r4 74 50 already already RB cord-302215-sqrbj5r4 74 51 been be VBN cord-302215-sqrbj5r4 74 52 discharged discharge VBN cord-302215-sqrbj5r4 74 53 , , , cord-302215-sqrbj5r4 74 54 which which WDT cord-302215-sqrbj5r4 74 55 is be VBZ cord-302215-sqrbj5r4 74 56 great great JJ cord-302215-sqrbj5r4 74 57 . . . cord-302215-sqrbj5r4 75 1 We -PRON- PRP cord-302215-sqrbj5r4 75 2 've have VB cord-302215-sqrbj5r4 75 3 only only RB cord-302215-sqrbj5r4 75 4 had have VBD cord-302215-sqrbj5r4 75 5 two two CD cord-302215-sqrbj5r4 75 6 patients patient NNS cord-302215-sqrbj5r4 75 7 perish perish VB cord-302215-sqrbj5r4 75 8 . . . cord-302215-sqrbj5r4 75 9 " " '' cord-302215-sqrbj5r4 76 1 However however RB cord-302215-sqrbj5r4 76 2 , , , cord-302215-sqrbj5r4 76 3 no no DT cord-302215-sqrbj5r4 76 4 placebo placebo NN cord-302215-sqrbj5r4 76 5 group group NN cord-302215-sqrbj5r4 76 6 was be VBD cord-302215-sqrbj5r4 76 7 included include VBN cord-302215-sqrbj5r4 76 8 in in IN cord-302215-sqrbj5r4 76 9 the the DT cord-302215-sqrbj5r4 76 10 trial trial NN cord-302215-sqrbj5r4 76 11 . . . cord-302215-sqrbj5r4 77 1 [ [ -LRB- cord-302215-sqrbj5r4 77 2 17 17 CD cord-302215-sqrbj5r4 77 3 ] ] -RRB- cord-302215-sqrbj5r4 78 1 On on IN cord-302215-sqrbj5r4 78 2 April April NNP cord-302215-sqrbj5r4 78 3 29 29 CD cord-302215-sqrbj5r4 78 4 , , , cord-302215-sqrbj5r4 78 5 Gilead Gilead NNP cord-302215-sqrbj5r4 78 6 disclosed disclose VBD cord-302215-sqrbj5r4 78 7 another another DT cord-302215-sqrbj5r4 78 8 partial partial JJ cord-302215-sqrbj5r4 78 9 result result NN cord-302215-sqrbj5r4 78 10 concerning concern VBG cord-302215-sqrbj5r4 78 11 the the DT cord-302215-sqrbj5r4 78 12 efficacy efficacy NN cord-302215-sqrbj5r4 78 13 of of IN cord-302215-sqrbj5r4 78 14 5-day 5-day JJ cord-302215-sqrbj5r4 78 15 and and CC cord-302215-sqrbj5r4 78 16 10-day 10-day CD cord-302215-sqrbj5r4 78 17 treatments treatment NNS cord-302215-sqrbj5r4 78 18 among among IN cord-302215-sqrbj5r4 78 19 397 397 CD cord-302215-sqrbj5r4 78 20 patients patient NNS cord-302215-sqrbj5r4 78 21 distributed distribute VBN cord-302215-sqrbj5r4 78 22 in in IN cord-302215-sqrbj5r4 78 23 a a DT cord-302215-sqrbj5r4 78 24 1:1 1:1 CD cord-302215-sqrbj5r4 78 25 ratio ratio NN cord-302215-sqrbj5r4 78 26 ( ( -LRB- cord-302215-sqrbj5r4 78 27 200:197 200:197 CD cord-302215-sqrbj5r4 78 28 ) ) -RRB- cord-302215-sqrbj5r4 78 29 . . . cord-302215-sqrbj5r4 79 1 Results result NNS cord-302215-sqrbj5r4 79 2 indicated indicate VBD cord-302215-sqrbj5r4 79 3 that that IN cord-302215-sqrbj5r4 79 4 " " `` cord-302215-sqrbj5r4 79 5 the the DT cord-302215-sqrbj5r4 79 6 study study NN cord-302215-sqrbj5r4 79 7 demonstrated demonstrate VBD cord-302215-sqrbj5r4 79 8 that that IN cord-302215-sqrbj5r4 79 9 patients patient NNS cord-302215-sqrbj5r4 79 10 receiving receive VBG cord-302215-sqrbj5r4 79 11 a a DT cord-302215-sqrbj5r4 79 12 10-day 10-day CD cord-302215-sqrbj5r4 79 13 treatment treatment NN cord-302215-sqrbj5r4 79 14 course course NN cord-302215-sqrbj5r4 79 15 of of IN cord-302215-sqrbj5r4 79 16 remdesivir remdesivir NNP cord-302215-sqrbj5r4 79 17 achieved achieve VBD cord-302215-sqrbj5r4 79 18 similar similar JJ cord-302215-sqrbj5r4 79 19 improvement improvement NN cord-302215-sqrbj5r4 79 20 in in IN cord-302215-sqrbj5r4 79 21 clinical clinical JJ cord-302215-sqrbj5r4 79 22 status status NN cord-302215-sqrbj5r4 79 23 compared compare VBN cord-302215-sqrbj5r4 79 24 with with IN cord-302215-sqrbj5r4 79 25 those those DT cord-302215-sqrbj5r4 79 26 taking take VBG cord-302215-sqrbj5r4 79 27 a a DT cord-302215-sqrbj5r4 79 28 5-day 5-day JJ cord-302215-sqrbj5r4 79 29 treatment treatment NN cord-302215-sqrbj5r4 79 30 course course NN cord-302215-sqrbj5r4 79 31 . . . cord-302215-sqrbj5r4 79 32 " " '' cord-302215-sqrbj5r4 80 1 A. A. NNP cord-302215-sqrbj5r4 80 2 Subramanian Subramanian NNP cord-302215-sqrbj5r4 80 3 , , , cord-302215-sqrbj5r4 80 4 a a DT cord-302215-sqrbj5r4 80 5 lead lead JJ cord-302215-sqrbj5r4 80 6 investigator investigator NN cord-302215-sqrbj5r4 80 7 for for IN cord-302215-sqrbj5r4 80 8 the the DT cord-302215-sqrbj5r4 80 9 Stanford Stanford NNP cord-302215-sqrbj5r4 80 10 University University NNP cord-302215-sqrbj5r4 80 11 School School NNP cord-302215-sqrbj5r4 80 12 of of IN cord-302215-sqrbj5r4 80 13 Medicine Medicine NNP cord-302215-sqrbj5r4 80 14 , , , cord-302215-sqrbj5r4 80 15 added add VBD cord-302215-sqrbj5r4 80 16 : : : cord-302215-sqrbj5r4 80 17 " " `` cord-302215-sqrbj5r4 80 18 While while IN cord-302215-sqrbj5r4 80 19 additional additional JJ cord-302215-sqrbj5r4 80 20 data datum NNS cord-302215-sqrbj5r4 80 21 are be VBP cord-302215-sqrbj5r4 80 22 still still RB cord-302215-sqrbj5r4 80 23 needed need VBN cord-302215-sqrbj5r4 80 24 , , , cord-302215-sqrbj5r4 80 25 these these DT cord-302215-sqrbj5r4 80 26 results result NNS cord-302215-sqrbj5r4 80 27 help help VBP cord-302215-sqrbj5r4 80 28 to to TO cord-302215-sqrbj5r4 80 29 bring bring VB cord-302215-sqrbj5r4 80 30 a a DT cord-302215-sqrbj5r4 80 31 clearer clear JJR cord-302215-sqrbj5r4 80 32 understanding understanding NN cord-302215-sqrbj5r4 80 33 of of IN cord-302215-sqrbj5r4 80 34 how how WRB cord-302215-sqrbj5r4 80 35 treatment treatment NN cord-302215-sqrbj5r4 80 36 with with IN cord-302215-sqrbj5r4 80 37 remdesivir remdesivir NNP cord-302215-sqrbj5r4 80 38 may may MD cord-302215-sqrbj5r4 80 39 be be VB cord-302215-sqrbj5r4 80 40 optimized optimize VBN cord-302215-sqrbj5r4 80 41 , , , cord-302215-sqrbj5r4 80 42 if if IN cord-302215-sqrbj5r4 80 43 proven prove VBN cord-302215-sqrbj5r4 80 44 safe safe JJ cord-302215-sqrbj5r4 80 45 and and CC cord-302215-sqrbj5r4 80 46 effective effective JJ cord-302215-sqrbj5r4 80 47 . . . cord-302215-sqrbj5r4 80 48 " " '' cord-302215-sqrbj5r4 81 1 [ [ -LRB- cord-302215-sqrbj5r4 81 2 18 18 CD cord-302215-sqrbj5r4 81 3 ] ] -RRB- cord-302215-sqrbj5r4 82 1 In in IN cord-302215-sqrbj5r4 82 2 an an DT cord-302215-sqrbj5r4 82 3 independent independent JJ cord-302215-sqrbj5r4 82 4 study study NN cord-302215-sqrbj5r4 82 5 , , , cord-302215-sqrbj5r4 82 6 Wang Wang NNP cord-302215-sqrbj5r4 82 7 et et NNP cord-302215-sqrbj5r4 82 8 al al NNP cord-302215-sqrbj5r4 82 9 . . NNP cord-302215-sqrbj5r4 82 10 examined examine VBD cord-302215-sqrbj5r4 82 11 236 236 CD cord-302215-sqrbj5r4 82 12 patients patient NNS cord-302215-sqrbj5r4 82 13 over over IN cord-302215-sqrbj5r4 82 14 10 10 CD cord-302215-sqrbj5r4 82 15 hospitals hospital NNS cord-302215-sqrbj5r4 82 16 in in IN cord-302215-sqrbj5r4 82 17 the the DT cord-302215-sqrbj5r4 82 18 province province NN cord-302215-sqrbj5r4 82 19 of of IN cord-302215-sqrbj5r4 82 20 Hubei Hubei NNP cord-302215-sqrbj5r4 82 21 , , , cord-302215-sqrbj5r4 82 22 China China NNP cord-302215-sqrbj5r4 82 23 . . . cord-302215-sqrbj5r4 83 1 In in IN cord-302215-sqrbj5r4 83 2 this this DT cord-302215-sqrbj5r4 83 3 randomized randomized JJ cord-302215-sqrbj5r4 83 4 , , , cord-302215-sqrbj5r4 83 5 double double JJ cord-302215-sqrbj5r4 83 6 - - HYPH cord-302215-sqrbj5r4 83 7 blind blind JJ cord-302215-sqrbj5r4 83 8 , , , cord-302215-sqrbj5r4 83 9 placebo placebo NN cord-302215-sqrbj5r4 83 10 - - HYPH cord-302215-sqrbj5r4 83 11 controlled control VBN cord-302215-sqrbj5r4 83 12 trial trial NN cord-302215-sqrbj5r4 83 13 , , , cord-302215-sqrbj5r4 83 14 158 158 CD cord-302215-sqrbj5r4 83 15 people people NNS cord-302215-sqrbj5r4 83 16 were be VBD cord-302215-sqrbj5r4 83 17 administered administer VBN cord-302215-sqrbj5r4 83 18 remdesivir remdesivir NNP cord-302215-sqrbj5r4 83 19 and and CC cord-302215-sqrbj5r4 83 20 78 78 CD cord-302215-sqrbj5r4 83 21 received receive VBD cord-302215-sqrbj5r4 83 22 a a DT cord-302215-sqrbj5r4 83 23 placebo placebo NN cord-302215-sqrbj5r4 83 24 . . . cord-302215-sqrbj5r4 84 1 The the DT cord-302215-sqrbj5r4 84 2 authors author NNS cord-302215-sqrbj5r4 84 3 interpreted interpret VBD cord-302215-sqrbj5r4 84 4 their -PRON- PRP$ cord-302215-sqrbj5r4 84 5 results result NNS cord-302215-sqrbj5r4 84 6 in in IN cord-302215-sqrbj5r4 84 7 the the DT cord-302215-sqrbj5r4 84 8 following follow VBG cord-302215-sqrbj5r4 84 9 terms term NNS cord-302215-sqrbj5r4 84 10 : : : cord-302215-sqrbj5r4 84 11 " " `` cord-302215-sqrbj5r4 84 12 In in IN cord-302215-sqrbj5r4 84 13 this this DT cord-302215-sqrbj5r4 84 14 study study NN cord-302215-sqrbj5r4 84 15 of of IN cord-302215-sqrbj5r4 84 16 adult adult NN cord-302215-sqrbj5r4 84 17 patients patient NNS cord-302215-sqrbj5r4 84 18 admitted admit VBN cord-302215-sqrbj5r4 84 19 to to IN cord-302215-sqrbj5r4 84 20 hospital hospital NN cord-302215-sqrbj5r4 84 21 for for IN cord-302215-sqrbj5r4 84 22 severe severe JJ cord-302215-sqrbj5r4 84 23 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 84 24 , , , cord-302215-sqrbj5r4 84 25 remdesivir remdesivir NNP cord-302215-sqrbj5r4 84 26 was be VBD cord-302215-sqrbj5r4 84 27 not not RB cord-302215-sqrbj5r4 84 28 associated associate VBN cord-302215-sqrbj5r4 84 29 with with IN cord-302215-sqrbj5r4 84 30 statistically statistically RB cord-302215-sqrbj5r4 84 31 significant significant JJ cord-302215-sqrbj5r4 84 32 clinical clinical JJ cord-302215-sqrbj5r4 84 33 benefits benefit NNS cord-302215-sqrbj5r4 84 34 . . . cord-302215-sqrbj5r4 85 1 However however RB cord-302215-sqrbj5r4 85 2 , , , cord-302215-sqrbj5r4 85 3 the the DT cord-302215-sqrbj5r4 85 4 numerical numerical JJ cord-302215-sqrbj5r4 85 5 reduction reduction NN cord-302215-sqrbj5r4 85 6 in in IN cord-302215-sqrbj5r4 85 7 time time NN cord-302215-sqrbj5r4 85 8 to to IN cord-302215-sqrbj5r4 85 9 clinical clinical JJ cord-302215-sqrbj5r4 85 10 improvement improvement NN cord-302215-sqrbj5r4 85 11 in in IN cord-302215-sqrbj5r4 85 12 those those DT cord-302215-sqrbj5r4 85 13 treated treat VBN cord-302215-sqrbj5r4 85 14 earlier early RBR cord-302215-sqrbj5r4 85 15 requires require VBZ cord-302215-sqrbj5r4 85 16 confirmation confirmation NN cord-302215-sqrbj5r4 85 17 in in IN cord-302215-sqrbj5r4 85 18 larger large JJR cord-302215-sqrbj5r4 85 19 studies study NNS cord-302215-sqrbj5r4 85 20 . . . cord-302215-sqrbj5r4 85 21 " " '' cord-302215-sqrbj5r4 85 22 [ [ -LRB- cord-302215-sqrbj5r4 85 23 19 19 CD cord-302215-sqrbj5r4 85 24 ] ] -RRB- cord-302215-sqrbj5r4 85 25 . . . cord-302215-sqrbj5r4 86 1 From from IN cord-302215-sqrbj5r4 86 2 a a DT cord-302215-sqrbj5r4 86 3 chemical chemical JJ cord-302215-sqrbj5r4 86 4 point point NN cord-302215-sqrbj5r4 86 5 of of IN cord-302215-sqrbj5r4 86 6 view view NN cord-302215-sqrbj5r4 86 7 , , , cord-302215-sqrbj5r4 86 8 it -PRON- PRP cord-302215-sqrbj5r4 86 9 must must MD cord-302215-sqrbj5r4 86 10 be be VB cord-302215-sqrbj5r4 86 11 underlined underline VBN cord-302215-sqrbj5r4 86 12 that that IN cord-302215-sqrbj5r4 86 13 remdesivir remdesivir NNP cord-302215-sqrbj5r4 86 14 has have VBZ cord-302215-sqrbj5r4 86 15 six six CD cord-302215-sqrbj5r4 86 16 chiral chiral JJ cord-302215-sqrbj5r4 86 17 centers center NNS cord-302215-sqrbj5r4 86 18 and and CC cord-302215-sqrbj5r4 86 19 is be VBZ cord-302215-sqrbj5r4 86 20 manufactured manufacture VBN cord-302215-sqrbj5r4 86 21 as as IN cord-302215-sqrbj5r4 86 22 a a DT cord-302215-sqrbj5r4 86 23 single single JJ cord-302215-sqrbj5r4 86 24 stereoisomer stereoisomer NN cord-302215-sqrbj5r4 86 25 under under IN cord-302215-sqrbj5r4 86 26 aseptic aseptic JJ cord-302215-sqrbj5r4 86 27 conditions condition NNS cord-302215-sqrbj5r4 86 28 . . . cord-302215-sqrbj5r4 87 1 Globally globally RB cord-302215-sqrbj5r4 87 2 , , , cord-302215-sqrbj5r4 87 3 its -PRON- PRP$ cord-302215-sqrbj5r4 87 4 synthesis synthesis NN cord-302215-sqrbj5r4 87 5 requires require VBZ cord-302215-sqrbj5r4 87 6 several several JJ cord-302215-sqrbj5r4 87 7 key key JJ cord-302215-sqrbj5r4 87 8 intermediates intermediate NNS cord-302215-sqrbj5r4 87 9 ( ( -LRB- cord-302215-sqrbj5r4 87 10 A A NNP cord-302215-sqrbj5r4 87 11 - - HYPH cord-302215-sqrbj5r4 87 12 F F NNP cord-302215-sqrbj5r4 87 13 ) ) -RRB- cord-302215-sqrbj5r4 87 14 represented represent VBD cord-302215-sqrbj5r4 87 15 in in IN cord-302215-sqrbj5r4 87 16 Figure figure NN cord-302215-sqrbj5r4 87 17 2 2 CD cord-302215-sqrbj5r4 87 18 [ [ -LRB- cord-302215-sqrbj5r4 87 19 20 20 CD cord-302215-sqrbj5r4 87 20 ] ] -RRB- cord-302215-sqrbj5r4 87 21 . . . cord-302215-sqrbj5r4 88 1 Therefore therefore RB cord-302215-sqrbj5r4 88 2 , , , cord-302215-sqrbj5r4 88 3 production production NN cord-302215-sqrbj5r4 88 4 relies rely VBZ cord-302215-sqrbj5r4 88 5 on on IN cord-302215-sqrbj5r4 88 6 different different JJ cord-302215-sqrbj5r4 88 7 suppliers supplier NNS cord-302215-sqrbj5r4 88 8 whose whose WP$ cord-302215-sqrbj5r4 88 9 capacities capacity NNS cord-302215-sqrbj5r4 88 10 must must MD cord-302215-sqrbj5r4 88 11 be be VB cord-302215-sqrbj5r4 88 12 expanded expand VBN cord-302215-sqrbj5r4 88 13 in in IN cord-302215-sqrbj5r4 88 14 order order NN cord-302215-sqrbj5r4 88 15 to to TO cord-302215-sqrbj5r4 88 16 satisfy satisfy VB cord-302215-sqrbj5r4 88 17 the the DT cord-302215-sqrbj5r4 88 18 eventual eventual JJ cord-302215-sqrbj5r4 88 19 high high JJ cord-302215-sqrbj5r4 88 20 demand demand NN cord-302215-sqrbj5r4 88 21 of of IN cord-302215-sqrbj5r4 88 22 doses dose NNS cord-302215-sqrbj5r4 88 23 , , , cord-302215-sqrbj5r4 88 24 as as IN cord-302215-sqrbj5r4 88 25 underlined underline VBN cord-302215-sqrbj5r4 88 26 by by IN cord-302215-sqrbj5r4 88 27 Gilead Gilead NNP cord-302215-sqrbj5r4 88 28 [ [ -LRB- cord-302215-sqrbj5r4 88 29 21 21 CD cord-302215-sqrbj5r4 88 30 , , , cord-302215-sqrbj5r4 88 31 22 22 CD cord-302215-sqrbj5r4 88 32 ] ] -RRB- cord-302215-sqrbj5r4 88 33 . . . cord-302215-sqrbj5r4 89 1 ( ( -LRB- cord-302215-sqrbj5r4 89 2 1 1 CD cord-302215-sqrbj5r4 89 3 ) ) -RRB- cord-302215-sqrbj5r4 89 4 . . . cord-302215-sqrbj5r4 90 1 Yields yield NNS cord-302215-sqrbj5r4 90 2 were be VBD cord-302215-sqrbj5r4 90 3 not not RB cord-302215-sqrbj5r4 90 4 mentioned mention VBN cord-302215-sqrbj5r4 90 5 in in IN cord-302215-sqrbj5r4 90 6 [ [ -LRB- cord-302215-sqrbj5r4 90 7 20 20 CD cord-302215-sqrbj5r4 90 8 ] ] -RRB- cord-302215-sqrbj5r4 90 9 . . . cord-302215-sqrbj5r4 91 1 Commercially commercially RB cord-302215-sqrbj5r4 91 2 available available JJ cord-302215-sqrbj5r4 91 3 under under IN cord-302215-sqrbj5r4 91 4 the the DT cord-302215-sqrbj5r4 91 5 brand brand NN cord-302215-sqrbj5r4 91 6 name name NN cord-302215-sqrbj5r4 91 7 Keletra Keletra NNP cord-302215-sqrbj5r4 91 8 ® ® VBP cord-302215-sqrbj5r4 91 9 , , , cord-302215-sqrbj5r4 91 10 the the DT cord-302215-sqrbj5r4 91 11 combination combination NN cord-302215-sqrbj5r4 91 12 is be VBZ cord-302215-sqrbj5r4 91 13 manufactured manufacture VBN cord-302215-sqrbj5r4 91 14 by by IN cord-302215-sqrbj5r4 91 15 AbbVie AbbVie NNP cord-302215-sqrbj5r4 91 16 in in IN cord-302215-sqrbj5r4 91 17 several several JJ cord-302215-sqrbj5r4 91 18 countries country NNS cord-302215-sqrbj5r4 91 19 of of IN cord-302215-sqrbj5r4 91 20 the the DT cord-302215-sqrbj5r4 91 21 world world NN cord-302215-sqrbj5r4 91 22 , , , cord-302215-sqrbj5r4 91 23 sometimes sometimes RB cord-302215-sqrbj5r4 91 24 in in IN cord-302215-sqrbj5r4 91 25 a a DT cord-302215-sqrbj5r4 91 26 generic generic JJ cord-302215-sqrbj5r4 91 27 version version NN cord-302215-sqrbj5r4 91 28 . . . cord-302215-sqrbj5r4 92 1 Availability availability NN cord-302215-sqrbj5r4 92 2 is be VBZ cord-302215-sqrbj5r4 92 3 not not RB cord-302215-sqrbj5r4 92 4 a a DT cord-302215-sqrbj5r4 92 5 concern concern NN cord-302215-sqrbj5r4 92 6 . . . cord-302215-sqrbj5r4 93 1 The the DT cord-302215-sqrbj5r4 93 2 combination combination NN cord-302215-sqrbj5r4 93 3 has have VBZ cord-302215-sqrbj5r4 93 4 been be VBN cord-302215-sqrbj5r4 93 5 the the DT cord-302215-sqrbj5r4 93 6 subject subject NN cord-302215-sqrbj5r4 93 7 of of IN cord-302215-sqrbj5r4 93 8 more more JJR cord-302215-sqrbj5r4 93 9 than than IN cord-302215-sqrbj5r4 93 10 400 400 CD cord-302215-sqrbj5r4 93 11 registered register VBN cord-302215-sqrbj5r4 93 12 clinical clinical JJ cord-302215-sqrbj5r4 93 13 trials trial NNS cord-302215-sqrbj5r4 93 14 [ [ -LRB- cord-302215-sqrbj5r4 93 15 3 3 CD cord-302215-sqrbj5r4 93 16 ] ] -RRB- cord-302215-sqrbj5r4 93 17 and and CC cord-302215-sqrbj5r4 93 18 it -PRON- PRP cord-302215-sqrbj5r4 93 19 is be VBZ cord-302215-sqrbj5r4 93 20 prescribed prescribe VBN cord-302215-sqrbj5r4 93 21 for for IN cord-302215-sqrbj5r4 93 22 treatment treatment NN cord-302215-sqrbj5r4 93 23 of of IN cord-302215-sqrbj5r4 93 24 HIV HIV NNP cord-302215-sqrbj5r4 93 25 infection infection NN cord-302215-sqrbj5r4 93 26 . . . cord-302215-sqrbj5r4 94 1 In in IN cord-302215-sqrbj5r4 94 2 the the DT cord-302215-sqrbj5r4 94 3 case case NN cord-302215-sqrbj5r4 94 4 of of IN cord-302215-sqrbj5r4 94 5 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 94 6 , , , cord-302215-sqrbj5r4 94 7 the the DT cord-302215-sqrbj5r4 94 8 combination combination NN cord-302215-sqrbj5r4 94 9 lopinavir lopinavir NNP cord-302215-sqrbj5r4 94 10 / / SYM cord-302215-sqrbj5r4 94 11 ritonavir ritonavir NNP cord-302215-sqrbj5r4 94 12 is be VBZ cord-302215-sqrbj5r4 94 13 evaluated evaluate VBN cord-302215-sqrbj5r4 94 14 in in IN cord-302215-sqrbj5r4 94 15 49 49 CD cord-302215-sqrbj5r4 94 16 clinical clinical JJ cord-302215-sqrbj5r4 94 17 trials trial NNS cord-302215-sqrbj5r4 94 18 . . . cord-302215-sqrbj5r4 95 1 There there EX cord-302215-sqrbj5r4 95 2 are be VBP cord-302215-sqrbj5r4 95 3 several several JJ cord-302215-sqrbj5r4 95 4 anecdotal anecdotal JJ cord-302215-sqrbj5r4 95 5 reports report NNS cord-302215-sqrbj5r4 95 6 indicating indicate VBG cord-302215-sqrbj5r4 95 7 that that IN cord-302215-sqrbj5r4 95 8 Japanese Japanese NNPS cord-302215-sqrbj5r4 95 9 , , , cord-302215-sqrbj5r4 95 10 Chinese Chinese NNPS cord-302215-sqrbj5r4 95 11 , , , cord-302215-sqrbj5r4 95 12 and and CC cord-302215-sqrbj5r4 95 13 Taiwanese taiwanese JJ cord-302215-sqrbj5r4 95 14 patients patient NNS cord-302215-sqrbj5r4 95 15 treated treat VBN cord-302215-sqrbj5r4 95 16 with with IN cord-302215-sqrbj5r4 95 17 lopinavir lopinavir NNS cord-302215-sqrbj5r4 95 18 / / SYM cord-302215-sqrbj5r4 95 19 ritonavir ritonavir NNP cord-302215-sqrbj5r4 95 20 survived survive VBD cord-302215-sqrbj5r4 95 21 the the DT cord-302215-sqrbj5r4 95 22 disease disease NN cord-302215-sqrbj5r4 95 23 , , , cord-302215-sqrbj5r4 95 24 but but CC cord-302215-sqrbj5r4 95 25 nothing nothing NN cord-302215-sqrbj5r4 95 26 indicated indicate VBD cord-302215-sqrbj5r4 95 27 the the DT cord-302215-sqrbj5r4 95 28 benefit benefit NN cord-302215-sqrbj5r4 95 29 of of IN cord-302215-sqrbj5r4 95 30 the the DT cord-302215-sqrbj5r4 95 31 use use NN cord-302215-sqrbj5r4 95 32 of of IN cord-302215-sqrbj5r4 95 33 those those DT cord-302215-sqrbj5r4 95 34 antiviral antiviral JJ cord-302215-sqrbj5r4 95 35 agents agent NNS cord-302215-sqrbj5r4 95 36 . . . cord-302215-sqrbj5r4 96 1 Addition addition NN cord-302215-sqrbj5r4 96 2 of of IN cord-302215-sqrbj5r4 96 3 umifenovir umifenovir NNS cord-302215-sqrbj5r4 97 1 ( ( -LRB- cord-302215-sqrbj5r4 97 2 Arbidol Arbidol NNP cord-302215-sqrbj5r4 97 3 ® ® . cord-302215-sqrbj5r4 97 4 ) ) -RRB- cord-302215-sqrbj5r4 97 5 to to IN cord-302215-sqrbj5r4 97 6 the the DT cord-302215-sqrbj5r4 97 7 combination combination NN cord-302215-sqrbj5r4 97 8 did do VBD cord-302215-sqrbj5r4 97 9 not not RB cord-302215-sqrbj5r4 97 10 show show VB cord-302215-sqrbj5r4 97 11 any any DT cord-302215-sqrbj5r4 97 12 improvement improvement NN cord-302215-sqrbj5r4 97 13 in in IN cord-302215-sqrbj5r4 97 14 the the DT cord-302215-sqrbj5r4 97 15 treatment treatment NN cord-302215-sqrbj5r4 97 16 [ [ -LRB- cord-302215-sqrbj5r4 97 17 23 23 CD cord-302215-sqrbj5r4 97 18 ] ] -RRB- cord-302215-sqrbj5r4 98 1 [ [ -LRB- cord-302215-sqrbj5r4 98 2 24 24 CD cord-302215-sqrbj5r4 98 3 ] ] -RRB- cord-302215-sqrbj5r4 98 4 [ [ -LRB- cord-302215-sqrbj5r4 98 5 25 25 CD cord-302215-sqrbj5r4 98 6 ] ] -RRB- cord-302215-sqrbj5r4 98 7 [ [ -LRB- cord-302215-sqrbj5r4 98 8 26 26 CD cord-302215-sqrbj5r4 98 9 ] ] -RRB- cord-302215-sqrbj5r4 98 10 [ [ -LRB- cord-302215-sqrbj5r4 98 11 27 27 CD cord-302215-sqrbj5r4 98 12 ] ] -RRB- cord-302215-sqrbj5r4 98 13 . . . cord-302215-sqrbj5r4 99 1 A a DT cord-302215-sqrbj5r4 99 2 randomized randomized JJ cord-302215-sqrbj5r4 99 3 , , , cord-302215-sqrbj5r4 99 4 controlled control VBN cord-302215-sqrbj5r4 99 5 , , , cord-302215-sqrbj5r4 99 6 open open JJ cord-302215-sqrbj5r4 99 7 - - HYPH cord-302215-sqrbj5r4 99 8 label label NN cord-302215-sqrbj5r4 99 9 trial trial NN cord-302215-sqrbj5r4 99 10 conducted conduct VBN cord-302215-sqrbj5r4 99 11 in in IN cord-302215-sqrbj5r4 99 12 Wuhan Wuhan NNP cord-302215-sqrbj5r4 99 13 ( ( -LRB- cord-302215-sqrbj5r4 99 14 China China NNP cord-302215-sqrbj5r4 99 15 ) ) -RRB- cord-302215-sqrbj5r4 99 16 concerned concern VBD cord-302215-sqrbj5r4 99 17 two two CD cord-302215-sqrbj5r4 99 18 groups group NNS cord-302215-sqrbj5r4 99 19 of of IN cord-302215-sqrbj5r4 99 20 99 99 CD cord-302215-sqrbj5r4 99 21 and and CC cord-302215-sqrbj5r4 99 22 100 100 CD cord-302215-sqrbj5r4 99 23 patients patient NNS cord-302215-sqrbj5r4 99 24 , , , cord-302215-sqrbj5r4 99 25 respectively respectively RB cord-302215-sqrbj5r4 99 26 . . . cord-302215-sqrbj5r4 100 1 The the DT cord-302215-sqrbj5r4 100 2 first first JJ cord-302215-sqrbj5r4 100 3 group group NN cord-302215-sqrbj5r4 100 4 was be VBD cord-302215-sqrbj5r4 100 5 assigned assign VBN cord-302215-sqrbj5r4 100 6 the the DT cord-302215-sqrbj5r4 100 7 combination combination NN cord-302215-sqrbj5r4 100 8 of of IN cord-302215-sqrbj5r4 100 9 antiviral antiviral JJ cord-302215-sqrbj5r4 100 10 drugs drug NNS cord-302215-sqrbj5r4 100 11 whereas whereas IN cord-302215-sqrbj5r4 100 12 the the DT cord-302215-sqrbj5r4 100 13 second second JJ cord-302215-sqrbj5r4 100 14 group group NN cord-302215-sqrbj5r4 100 15 received receive VBD cord-302215-sqrbj5r4 100 16 standard standard JJ cord-302215-sqrbj5r4 100 17 care care NN cord-302215-sqrbj5r4 100 18 . . . cord-302215-sqrbj5r4 101 1 The the DT cord-302215-sqrbj5r4 101 2 authors author NNS cord-302215-sqrbj5r4 101 3 [ [ -LRB- cord-302215-sqrbj5r4 101 4 28 28 CD cord-302215-sqrbj5r4 101 5 ] ] -RRB- cord-302215-sqrbj5r4 101 6 concluded conclude VBD cord-302215-sqrbj5r4 101 7 : : : cord-302215-sqrbj5r4 101 8 " " `` cord-302215-sqrbj5r4 101 9 we -PRON- PRP cord-302215-sqrbj5r4 101 10 found find VBD cord-302215-sqrbj5r4 101 11 that that IN cord-302215-sqrbj5r4 101 12 lopinavir lopinavir NNP cord-302215-sqrbj5r4 101 13 - - HYPH cord-302215-sqrbj5r4 101 14 ritonavir ritonavir NNP cord-302215-sqrbj5r4 101 15 treatment treatment NN cord-302215-sqrbj5r4 101 16 did do VBD cord-302215-sqrbj5r4 101 17 not not RB cord-302215-sqrbj5r4 101 18 significantly significantly RB cord-302215-sqrbj5r4 101 19 accelerate accelerate VB cord-302215-sqrbj5r4 101 20 clinical clinical JJ cord-302215-sqrbj5r4 101 21 improvement improvement NN cord-302215-sqrbj5r4 101 22 , , , cord-302215-sqrbj5r4 101 23 reduce reduce VB cord-302215-sqrbj5r4 101 24 mortality mortality NN cord-302215-sqrbj5r4 101 25 , , , cord-302215-sqrbj5r4 101 26 or or CC cord-302215-sqrbj5r4 101 27 diminish diminish VB cord-302215-sqrbj5r4 101 28 throat throat JJ cord-302215-sqrbj5r4 101 29 viral viral JJ cord-302215-sqrbj5r4 101 30 RNA RNA NNP cord-302215-sqrbj5r4 101 31 detectability detectability NN cord-302215-sqrbj5r4 101 32 in in IN cord-302215-sqrbj5r4 101 33 patients patient NNS cord-302215-sqrbj5r4 101 34 with with IN cord-302215-sqrbj5r4 101 35 serious serious JJ cord-302215-sqrbj5r4 101 36 Covid-19 covid-19 NN cord-302215-sqrbj5r4 101 37 . . . cord-302215-sqrbj5r4 101 38 " " '' cord-302215-sqrbj5r4 101 39 . . . cord-302215-sqrbj5r4 102 1 Both both DT cord-302215-sqrbj5r4 102 2 molecules molecule NNS cord-302215-sqrbj5r4 102 3 are be VBP cord-302215-sqrbj5r4 102 4 frequently frequently RB cord-302215-sqrbj5r4 102 5 prescribed prescribe VBN cord-302215-sqrbj5r4 102 6 for for IN cord-302215-sqrbj5r4 102 7 the the DT cord-302215-sqrbj5r4 102 8 treatment treatment NN cord-302215-sqrbj5r4 102 9 of of IN cord-302215-sqrbj5r4 102 10 malaria malaria NN cord-302215-sqrbj5r4 102 11 since since IN cord-302215-sqrbj5r4 102 12 decades decade NNS cord-302215-sqrbj5r4 102 13 and and CC cord-302215-sqrbj5r4 102 14 have have VBP cord-302215-sqrbj5r4 102 15 been be VBN cord-302215-sqrbj5r4 102 16 largely largely RB cord-302215-sqrbj5r4 102 17 studied study VBN cord-302215-sqrbj5r4 102 18 . . . cord-302215-sqrbj5r4 103 1 Their -PRON- PRP$ cord-302215-sqrbj5r4 103 2 side side NN cord-302215-sqrbj5r4 103 3 - - HYPH cord-302215-sqrbj5r4 103 4 effects effect NNS cord-302215-sqrbj5r4 103 5 are be VBP cord-302215-sqrbj5r4 103 6 widely widely RB cord-302215-sqrbj5r4 103 7 known know VBN cord-302215-sqrbj5r4 103 8 as as RB cord-302215-sqrbj5r4 103 9 well well RB cord-302215-sqrbj5r4 103 10 as as IN cord-302215-sqrbj5r4 103 11 all all DT cord-302215-sqrbj5r4 103 12 their -PRON- PRP$ cord-302215-sqrbj5r4 103 13 pharmacological pharmacological JJ cord-302215-sqrbj5r4 103 14 properties property NNS cord-302215-sqrbj5r4 103 15 . . . cord-302215-sqrbj5r4 104 1 Both both DT cord-302215-sqrbj5r4 104 2 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 104 3 ( ( -LRB- cord-302215-sqrbj5r4 104 4 Plaquenil Plaquenil NNP cord-302215-sqrbj5r4 104 5 ® ® VBP cord-302215-sqrbj5r4 104 6 ) ) -RRB- cord-302215-sqrbj5r4 104 7 and and CC cord-302215-sqrbj5r4 104 8 chloroquine chloroquine NN cord-302215-sqrbj5r4 104 9 ( ( -LRB- cord-302215-sqrbj5r4 104 10 Aralen Aralen NNP cord-302215-sqrbj5r4 104 11 ® ® , cord-302215-sqrbj5r4 104 12 ) ) -RRB- cord-302215-sqrbj5r4 104 13 have have VBP cord-302215-sqrbj5r4 104 14 been be VBN cord-302215-sqrbj5r4 104 15 clinically clinically RB cord-302215-sqrbj5r4 104 16 tested test VBN cord-302215-sqrbj5r4 104 17 for for IN cord-302215-sqrbj5r4 104 18 their -PRON- PRP$ cord-302215-sqrbj5r4 104 19 anti anti JJ cord-302215-sqrbj5r4 104 20 - - JJ cord-302215-sqrbj5r4 104 21 HIV hiv JJ cord-302215-sqrbj5r4 104 22 activity activity NN cord-302215-sqrbj5r4 104 23 [ [ -LRB- cord-302215-sqrbj5r4 104 24 3 3 CD cord-302215-sqrbj5r4 104 25 , , , cord-302215-sqrbj5r4 104 26 29 29 CD cord-302215-sqrbj5r4 104 27 ] ] -RRB- cord-302215-sqrbj5r4 104 28 . . . cord-302215-sqrbj5r4 105 1 Hydroxychloroquine Hydroxychloroquine NNP cord-302215-sqrbj5r4 105 2 is be VBZ cord-302215-sqrbj5r4 105 3 also also RB cord-302215-sqrbj5r4 105 4 recommended recommend VBN cord-302215-sqrbj5r4 105 5 to to TO cord-302215-sqrbj5r4 105 6 treat treat VB cord-302215-sqrbj5r4 105 7 lupus lupus NN cord-302215-sqrbj5r4 105 8 erythematosus erythematosus NN cord-302215-sqrbj5r4 105 9 and and CC cord-302215-sqrbj5r4 105 10 rheumatoid rheumatoid NN cord-302215-sqrbj5r4 105 11 arthritis arthritis NN cord-302215-sqrbj5r4 105 12 [ [ -LRB- cord-302215-sqrbj5r4 105 13 30 30 CD cord-302215-sqrbj5r4 105 14 ] ] -RRB- cord-302215-sqrbj5r4 105 15 . . . cord-302215-sqrbj5r4 106 1 Hydroxychloroquine Hydroxychloroquine NNP cord-302215-sqrbj5r4 106 2 and and CC cord-302215-sqrbj5r4 106 3 chloroquine chloroquine NN cord-302215-sqrbj5r4 106 4 , , , cord-302215-sqrbj5r4 106 5 eventually eventually RB cord-302215-sqrbj5r4 106 6 associated associate VBD cord-302215-sqrbj5r4 106 7 with with IN cord-302215-sqrbj5r4 106 8 an an DT cord-302215-sqrbj5r4 106 9 antibiotic antibiotic NN cord-302215-sqrbj5r4 106 10 , , , cord-302215-sqrbj5r4 106 11 are be VBP cord-302215-sqrbj5r4 106 12 the the DT cord-302215-sqrbj5r4 106 13 subjects subject NNS cord-302215-sqrbj5r4 106 14 of of IN cord-302215-sqrbj5r4 106 15 many many JJ cord-302215-sqrbj5r4 106 16 contradictory contradictory JJ cord-302215-sqrbj5r4 106 17 reports report NNS cord-302215-sqrbj5r4 106 18 about about IN cord-302215-sqrbj5r4 106 19 their -PRON- PRP$ cord-302215-sqrbj5r4 106 20 usefulness usefulness NN cord-302215-sqrbj5r4 106 21 in in IN cord-302215-sqrbj5r4 106 22 the the DT cord-302215-sqrbj5r4 106 23 treatment treatment NN cord-302215-sqrbj5r4 106 24 of of IN cord-302215-sqrbj5r4 106 25 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 106 26 . . . cord-302215-sqrbj5r4 107 1 Positive positive JJ cord-302215-sqrbj5r4 107 2 effects effect NNS cord-302215-sqrbj5r4 107 3 with with IN cord-302215-sqrbj5r4 107 4 viral viral JJ cord-302215-sqrbj5r4 107 5 clearance clearance NN cord-302215-sqrbj5r4 107 6 have have VBP cord-302215-sqrbj5r4 107 7 been be VBN cord-302215-sqrbj5r4 107 8 observed observe VBN cord-302215-sqrbj5r4 107 9 whereas whereas IN cord-302215-sqrbj5r4 107 10 other other JJ cord-302215-sqrbj5r4 107 11 groups group NNS cord-302215-sqrbj5r4 107 12 concluded conclude VBD cord-302215-sqrbj5r4 107 13 at at IN cord-302215-sqrbj5r4 107 14 the the DT cord-302215-sqrbj5r4 107 15 absence absence NN cord-302215-sqrbj5r4 107 16 of of IN cord-302215-sqrbj5r4 107 17 efficacy efficacy NN cord-302215-sqrbj5r4 107 18 or or CC cord-302215-sqrbj5r4 107 19 at at IN cord-302215-sqrbj5r4 107 20 cardiotoxicity cardiotoxicity NN cord-302215-sqrbj5r4 107 21 when when WRB cord-302215-sqrbj5r4 107 22 compared compare VBN cord-302215-sqrbj5r4 107 23 with with IN cord-302215-sqrbj5r4 107 24 standard standard JJ cord-302215-sqrbj5r4 107 25 care care NN cord-302215-sqrbj5r4 107 26 . . . cord-302215-sqrbj5r4 108 1 Discussions discussion NNS cord-302215-sqrbj5r4 108 2 are be VBP cord-302215-sqrbj5r4 108 3 articulated articulate VBN cord-302215-sqrbj5r4 108 4 among among IN cord-302215-sqrbj5r4 108 5 four four CD cord-302215-sqrbj5r4 108 6 main main JJ cord-302215-sqrbj5r4 108 7 aspects aspect NNS cord-302215-sqrbj5r4 108 8 that that WDT cord-302215-sqrbj5r4 108 9 should should MD cord-302215-sqrbj5r4 108 10 be be VB cord-302215-sqrbj5r4 108 11 taken take VBN cord-302215-sqrbj5r4 108 12 in in IN cord-302215-sqrbj5r4 108 13 account account NN cord-302215-sqrbj5r4 108 14 : : : cord-302215-sqrbj5r4 108 15 ( ( -LRB- cord-302215-sqrbj5r4 108 16 i i NN cord-302215-sqrbj5r4 108 17 ) ) -RRB- cord-302215-sqrbj5r4 108 18 stage stage NN cord-302215-sqrbj5r4 108 19 of of IN cord-302215-sqrbj5r4 108 20 the the DT cord-302215-sqrbj5r4 108 21 disease disease NN cord-302215-sqrbj5r4 108 22 ; ; . cord-302215-sqrbj5r4 109 1 ( ( -LRB- cord-302215-sqrbj5r4 109 2 ii ii LS cord-302215-sqrbj5r4 109 3 ) ) -RRB- cord-302215-sqrbj5r4 109 4 presence presence NN cord-302215-sqrbj5r4 109 5 / / SYM cord-302215-sqrbj5r4 109 6 absence absence NN cord-302215-sqrbj5r4 109 7 of of IN cord-302215-sqrbj5r4 109 8 a a DT cord-302215-sqrbj5r4 109 9 control control NN cord-302215-sqrbj5r4 109 10 group group NN cord-302215-sqrbj5r4 110 1 ; ; : cord-302215-sqrbj5r4 110 2 ( ( -LRB- cord-302215-sqrbj5r4 110 3 iii iii NN cord-302215-sqrbj5r4 110 4 ) ) -RRB- cord-302215-sqrbj5r4 110 5 efficacy efficacy NN cord-302215-sqrbj5r4 110 6 ; ; : cord-302215-sqrbj5r4 110 7 ( ( -LRB- cord-302215-sqrbj5r4 110 8 iv iv LS cord-302215-sqrbj5r4 110 9 ) ) -RRB- cord-302215-sqrbj5r4 110 10 safety safety NN cord-302215-sqrbj5r4 110 11 . . . cord-302215-sqrbj5r4 111 1 As as IN cord-302215-sqrbj5r4 111 2 earlier early RBR cord-302215-sqrbj5r4 111 3 mentioned mention VBN cord-302215-sqrbj5r4 111 4 , , , cord-302215-sqrbj5r4 111 5 controversial controversial JJ cord-302215-sqrbj5r4 111 6 results result NNS cord-302215-sqrbj5r4 111 7 have have VBP cord-302215-sqrbj5r4 111 8 been be VBN cord-302215-sqrbj5r4 111 9 published publish VBN cord-302215-sqrbj5r4 111 10 on on IN cord-302215-sqrbj5r4 111 11 the the DT cord-302215-sqrbj5r4 111 12 efficacy efficacy NN cord-302215-sqrbj5r4 111 13 of of IN cord-302215-sqrbj5r4 111 14 treatments treatment NNS cord-302215-sqrbj5r4 111 15 associating associate VBG cord-302215-sqrbj5r4 111 16 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 111 17 and and CC cord-302215-sqrbj5r4 111 18 azithromycin azithromycin NN cord-302215-sqrbj5r4 111 19 for for IN cord-302215-sqrbj5r4 111 20 French french JJ cord-302215-sqrbj5r4 111 21 patients patient NNS cord-302215-sqrbj5r4 111 22 hospitalized hospitalize VBN cord-302215-sqrbj5r4 111 23 for for IN cord-302215-sqrbj5r4 111 24 moderate moderate JJ cord-302215-sqrbj5r4 111 25 [ [ -LRB- cord-302215-sqrbj5r4 111 26 31 31 CD cord-302215-sqrbj5r4 111 27 ] ] -RRB- cord-302215-sqrbj5r4 111 28 _SP cord-302215-sqrbj5r4 111 29 Commercially commercially RB cord-302215-sqrbj5r4 111 30 available available JJ cord-302215-sqrbj5r4 111 31 under under IN cord-302215-sqrbj5r4 111 32 the the DT cord-302215-sqrbj5r4 111 33 brand brand NN cord-302215-sqrbj5r4 111 34 name name NN cord-302215-sqrbj5r4 111 35 Keletra Keletra NNP cord-302215-sqrbj5r4 111 36 ® ® VBP cord-302215-sqrbj5r4 111 37 , , , cord-302215-sqrbj5r4 111 38 the the DT cord-302215-sqrbj5r4 111 39 combination combination NN cord-302215-sqrbj5r4 111 40 is be VBZ cord-302215-sqrbj5r4 111 41 manufactured manufacture VBN cord-302215-sqrbj5r4 111 42 by by IN cord-302215-sqrbj5r4 111 43 AbbVie AbbVie NNP cord-302215-sqrbj5r4 111 44 in in IN cord-302215-sqrbj5r4 111 45 several several JJ cord-302215-sqrbj5r4 111 46 countries country NNS cord-302215-sqrbj5r4 111 47 of of IN cord-302215-sqrbj5r4 111 48 the the DT cord-302215-sqrbj5r4 111 49 world world NN cord-302215-sqrbj5r4 111 50 , , , cord-302215-sqrbj5r4 111 51 sometimes sometimes RB cord-302215-sqrbj5r4 111 52 in in IN cord-302215-sqrbj5r4 111 53 a a DT cord-302215-sqrbj5r4 111 54 generic generic JJ cord-302215-sqrbj5r4 111 55 version version NN cord-302215-sqrbj5r4 111 56 . . . cord-302215-sqrbj5r4 112 1 Availability availability NN cord-302215-sqrbj5r4 112 2 is be VBZ cord-302215-sqrbj5r4 112 3 not not RB cord-302215-sqrbj5r4 112 4 a a DT cord-302215-sqrbj5r4 112 5 concern concern NN cord-302215-sqrbj5r4 112 6 . . . cord-302215-sqrbj5r4 113 1 The the DT cord-302215-sqrbj5r4 113 2 combination combination NN cord-302215-sqrbj5r4 113 3 has have VBZ cord-302215-sqrbj5r4 113 4 been be VBN cord-302215-sqrbj5r4 113 5 the the DT cord-302215-sqrbj5r4 113 6 subject subject NN cord-302215-sqrbj5r4 113 7 of of IN cord-302215-sqrbj5r4 113 8 more more JJR cord-302215-sqrbj5r4 113 9 than than IN cord-302215-sqrbj5r4 113 10 400 400 CD cord-302215-sqrbj5r4 113 11 registered register VBN cord-302215-sqrbj5r4 113 12 clinical clinical JJ cord-302215-sqrbj5r4 113 13 trials trial NNS cord-302215-sqrbj5r4 113 14 [ [ -LRB- cord-302215-sqrbj5r4 113 15 3 3 CD cord-302215-sqrbj5r4 113 16 ] ] -RRB- cord-302215-sqrbj5r4 113 17 and and CC cord-302215-sqrbj5r4 113 18 it -PRON- PRP cord-302215-sqrbj5r4 113 19 is be VBZ cord-302215-sqrbj5r4 113 20 prescribed prescribe VBN cord-302215-sqrbj5r4 113 21 for for IN cord-302215-sqrbj5r4 113 22 treatment treatment NN cord-302215-sqrbj5r4 113 23 of of IN cord-302215-sqrbj5r4 113 24 HIV HIV NNP cord-302215-sqrbj5r4 113 25 infection infection NN cord-302215-sqrbj5r4 113 26 . . . cord-302215-sqrbj5r4 114 1 In in IN cord-302215-sqrbj5r4 114 2 the the DT cord-302215-sqrbj5r4 114 3 case case NN cord-302215-sqrbj5r4 114 4 of of IN cord-302215-sqrbj5r4 114 5 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 114 6 , , , cord-302215-sqrbj5r4 114 7 the the DT cord-302215-sqrbj5r4 114 8 combination combination NN cord-302215-sqrbj5r4 114 9 lopinavir lopinavir NNP cord-302215-sqrbj5r4 114 10 / / SYM cord-302215-sqrbj5r4 114 11 ritonavir ritonavir NNP cord-302215-sqrbj5r4 114 12 is be VBZ cord-302215-sqrbj5r4 114 13 evaluated evaluate VBN cord-302215-sqrbj5r4 114 14 in in IN cord-302215-sqrbj5r4 114 15 49 49 CD cord-302215-sqrbj5r4 114 16 clinical clinical JJ cord-302215-sqrbj5r4 114 17 trials trial NNS cord-302215-sqrbj5r4 114 18 . . . cord-302215-sqrbj5r4 115 1 There there EX cord-302215-sqrbj5r4 115 2 are be VBP cord-302215-sqrbj5r4 115 3 several several JJ cord-302215-sqrbj5r4 115 4 anecdotal anecdotal JJ cord-302215-sqrbj5r4 115 5 reports report NNS cord-302215-sqrbj5r4 115 6 indicating indicate VBG cord-302215-sqrbj5r4 115 7 that that IN cord-302215-sqrbj5r4 115 8 Japanese Japanese NNPS cord-302215-sqrbj5r4 115 9 , , , cord-302215-sqrbj5r4 115 10 Chinese Chinese NNPS cord-302215-sqrbj5r4 115 11 , , , cord-302215-sqrbj5r4 115 12 and and CC cord-302215-sqrbj5r4 115 13 Taiwanese taiwanese JJ cord-302215-sqrbj5r4 115 14 patients patient NNS cord-302215-sqrbj5r4 115 15 treated treat VBN cord-302215-sqrbj5r4 115 16 with with IN cord-302215-sqrbj5r4 115 17 lopinavir lopinavir NNS cord-302215-sqrbj5r4 115 18 / / SYM cord-302215-sqrbj5r4 115 19 ritonavir ritonavir NNP cord-302215-sqrbj5r4 115 20 survived survive VBD cord-302215-sqrbj5r4 115 21 the the DT cord-302215-sqrbj5r4 115 22 disease disease NN cord-302215-sqrbj5r4 115 23 , , , cord-302215-sqrbj5r4 115 24 but but CC cord-302215-sqrbj5r4 115 25 nothing nothing NN cord-302215-sqrbj5r4 115 26 indicated indicate VBD cord-302215-sqrbj5r4 115 27 the the DT cord-302215-sqrbj5r4 115 28 benefit benefit NN cord-302215-sqrbj5r4 115 29 of of IN cord-302215-sqrbj5r4 115 30 the the DT cord-302215-sqrbj5r4 115 31 use use NN cord-302215-sqrbj5r4 115 32 of of IN cord-302215-sqrbj5r4 115 33 those those DT cord-302215-sqrbj5r4 115 34 antiviral antiviral JJ cord-302215-sqrbj5r4 115 35 agents agent NNS cord-302215-sqrbj5r4 115 36 . . . cord-302215-sqrbj5r4 116 1 Addition addition NN cord-302215-sqrbj5r4 116 2 of of IN cord-302215-sqrbj5r4 116 3 umifenovir umifenovir NNS cord-302215-sqrbj5r4 117 1 ( ( -LRB- cord-302215-sqrbj5r4 117 2 Arbidol Arbidol NNP cord-302215-sqrbj5r4 117 3 ® ® . cord-302215-sqrbj5r4 117 4 ) ) -RRB- cord-302215-sqrbj5r4 117 5 to to IN cord-302215-sqrbj5r4 117 6 the the DT cord-302215-sqrbj5r4 117 7 combination combination NN cord-302215-sqrbj5r4 117 8 did do VBD cord-302215-sqrbj5r4 117 9 not not RB cord-302215-sqrbj5r4 117 10 show show VB cord-302215-sqrbj5r4 117 11 any any DT cord-302215-sqrbj5r4 117 12 improvement improvement NN cord-302215-sqrbj5r4 117 13 in in IN cord-302215-sqrbj5r4 117 14 the the DT cord-302215-sqrbj5r4 117 15 treatment treatment NN cord-302215-sqrbj5r4 117 16 [ [ -LRB- cord-302215-sqrbj5r4 117 17 23 23 CD cord-302215-sqrbj5r4 117 18 ] ] -RRB- cord-302215-sqrbj5r4 118 1 [ [ -LRB- cord-302215-sqrbj5r4 118 2 24 24 CD cord-302215-sqrbj5r4 118 3 ] ] -RRB- cord-302215-sqrbj5r4 118 4 [ [ -LRB- cord-302215-sqrbj5r4 118 5 25 25 CD cord-302215-sqrbj5r4 118 6 ] ] -RRB- cord-302215-sqrbj5r4 118 7 [ [ -LRB- cord-302215-sqrbj5r4 118 8 26 26 CD cord-302215-sqrbj5r4 118 9 ] ] -RRB- cord-302215-sqrbj5r4 118 10 [ [ -LRB- cord-302215-sqrbj5r4 118 11 27 27 CD cord-302215-sqrbj5r4 118 12 ] ] -RRB- cord-302215-sqrbj5r4 118 13 . . . cord-302215-sqrbj5r4 119 1 A a DT cord-302215-sqrbj5r4 119 2 randomized randomized JJ cord-302215-sqrbj5r4 119 3 , , , cord-302215-sqrbj5r4 119 4 controlled control VBN cord-302215-sqrbj5r4 119 5 , , , cord-302215-sqrbj5r4 119 6 open open JJ cord-302215-sqrbj5r4 119 7 - - HYPH cord-302215-sqrbj5r4 119 8 label label NN cord-302215-sqrbj5r4 119 9 trial trial NN cord-302215-sqrbj5r4 119 10 conducted conduct VBN cord-302215-sqrbj5r4 119 11 in in IN cord-302215-sqrbj5r4 119 12 Wuhan Wuhan NNP cord-302215-sqrbj5r4 119 13 ( ( -LRB- cord-302215-sqrbj5r4 119 14 China China NNP cord-302215-sqrbj5r4 119 15 ) ) -RRB- cord-302215-sqrbj5r4 119 16 concerned concern VBD cord-302215-sqrbj5r4 119 17 two two CD cord-302215-sqrbj5r4 119 18 groups group NNS cord-302215-sqrbj5r4 119 19 of of IN cord-302215-sqrbj5r4 119 20 99 99 CD cord-302215-sqrbj5r4 119 21 and and CC cord-302215-sqrbj5r4 119 22 100 100 CD cord-302215-sqrbj5r4 119 23 patients patient NNS cord-302215-sqrbj5r4 119 24 , , , cord-302215-sqrbj5r4 119 25 respectively respectively RB cord-302215-sqrbj5r4 119 26 . . . cord-302215-sqrbj5r4 120 1 The the DT cord-302215-sqrbj5r4 120 2 first first JJ cord-302215-sqrbj5r4 120 3 group group NN cord-302215-sqrbj5r4 120 4 was be VBD cord-302215-sqrbj5r4 120 5 assigned assign VBN cord-302215-sqrbj5r4 120 6 the the DT cord-302215-sqrbj5r4 120 7 combination combination NN cord-302215-sqrbj5r4 120 8 of of IN cord-302215-sqrbj5r4 120 9 antiviral antiviral JJ cord-302215-sqrbj5r4 120 10 drugs drug NNS cord-302215-sqrbj5r4 120 11 whereas whereas IN cord-302215-sqrbj5r4 120 12 the the DT cord-302215-sqrbj5r4 120 13 second second JJ cord-302215-sqrbj5r4 120 14 group group NN cord-302215-sqrbj5r4 120 15 received receive VBD cord-302215-sqrbj5r4 120 16 standard standard JJ cord-302215-sqrbj5r4 120 17 care care NN cord-302215-sqrbj5r4 120 18 . . . cord-302215-sqrbj5r4 121 1 The the DT cord-302215-sqrbj5r4 121 2 authors author NNS cord-302215-sqrbj5r4 121 3 [ [ -LRB- cord-302215-sqrbj5r4 121 4 28 28 CD cord-302215-sqrbj5r4 121 5 ] ] -RRB- cord-302215-sqrbj5r4 121 6 concluded conclude VBD cord-302215-sqrbj5r4 121 7 : : : cord-302215-sqrbj5r4 121 8 " " `` cord-302215-sqrbj5r4 121 9 we -PRON- PRP cord-302215-sqrbj5r4 121 10 found find VBD cord-302215-sqrbj5r4 121 11 that that IN cord-302215-sqrbj5r4 121 12 lopinavir lopinavir NNP cord-302215-sqrbj5r4 121 13 - - HYPH cord-302215-sqrbj5r4 121 14 ritonavir ritonavir NNP cord-302215-sqrbj5r4 121 15 treatment treatment NN cord-302215-sqrbj5r4 121 16 did do VBD cord-302215-sqrbj5r4 121 17 not not RB cord-302215-sqrbj5r4 121 18 significantly significantly RB cord-302215-sqrbj5r4 121 19 accelerate accelerate VB cord-302215-sqrbj5r4 121 20 clinical clinical JJ cord-302215-sqrbj5r4 121 21 improvement improvement NN cord-302215-sqrbj5r4 121 22 , , , cord-302215-sqrbj5r4 121 23 reduce reduce VB cord-302215-sqrbj5r4 121 24 mortality mortality NN cord-302215-sqrbj5r4 121 25 , , , cord-302215-sqrbj5r4 121 26 or or CC cord-302215-sqrbj5r4 121 27 diminish diminish VB cord-302215-sqrbj5r4 121 28 throat throat JJ cord-302215-sqrbj5r4 121 29 viral viral JJ cord-302215-sqrbj5r4 121 30 RNA RNA NNP cord-302215-sqrbj5r4 121 31 detectability detectability NN cord-302215-sqrbj5r4 121 32 in in IN cord-302215-sqrbj5r4 121 33 patients patient NNS cord-302215-sqrbj5r4 121 34 with with IN cord-302215-sqrbj5r4 121 35 serious serious JJ cord-302215-sqrbj5r4 121 36 Covid-19 covid-19 NN cord-302215-sqrbj5r4 121 37 . . . cord-302215-sqrbj5r4 121 38 " " '' cord-302215-sqrbj5r4 121 39 . . . cord-302215-sqrbj5r4 122 1 Both both DT cord-302215-sqrbj5r4 122 2 molecules molecule NNS cord-302215-sqrbj5r4 122 3 are be VBP cord-302215-sqrbj5r4 122 4 frequently frequently RB cord-302215-sqrbj5r4 122 5 prescribed prescribe VBN cord-302215-sqrbj5r4 122 6 for for IN cord-302215-sqrbj5r4 122 7 the the DT cord-302215-sqrbj5r4 122 8 treatment treatment NN cord-302215-sqrbj5r4 122 9 of of IN cord-302215-sqrbj5r4 122 10 malaria malaria NN cord-302215-sqrbj5r4 122 11 since since IN cord-302215-sqrbj5r4 122 12 decades decade NNS cord-302215-sqrbj5r4 122 13 and and CC cord-302215-sqrbj5r4 122 14 have have VBP cord-302215-sqrbj5r4 122 15 been be VBN cord-302215-sqrbj5r4 122 16 largely largely RB cord-302215-sqrbj5r4 122 17 studied study VBN cord-302215-sqrbj5r4 122 18 . . . cord-302215-sqrbj5r4 123 1 Their -PRON- PRP$ cord-302215-sqrbj5r4 123 2 side side NN cord-302215-sqrbj5r4 123 3 - - HYPH cord-302215-sqrbj5r4 123 4 effects effect NNS cord-302215-sqrbj5r4 123 5 are be VBP cord-302215-sqrbj5r4 123 6 widely widely RB cord-302215-sqrbj5r4 123 7 known know VBN cord-302215-sqrbj5r4 123 8 as as RB cord-302215-sqrbj5r4 123 9 well well RB cord-302215-sqrbj5r4 123 10 as as IN cord-302215-sqrbj5r4 123 11 all all DT cord-302215-sqrbj5r4 123 12 their -PRON- PRP$ cord-302215-sqrbj5r4 123 13 pharmacological pharmacological JJ cord-302215-sqrbj5r4 123 14 properties property NNS cord-302215-sqrbj5r4 123 15 . . . cord-302215-sqrbj5r4 124 1 Both both DT cord-302215-sqrbj5r4 124 2 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 124 3 ( ( -LRB- cord-302215-sqrbj5r4 124 4 Plaquenil Plaquenil NNP cord-302215-sqrbj5r4 124 5 ® ® VBP cord-302215-sqrbj5r4 124 6 ) ) -RRB- cord-302215-sqrbj5r4 124 7 and and CC cord-302215-sqrbj5r4 124 8 chloroquine chloroquine NN cord-302215-sqrbj5r4 124 9 ( ( -LRB- cord-302215-sqrbj5r4 124 10 Aralen Aralen NNP cord-302215-sqrbj5r4 124 11 ® ® , cord-302215-sqrbj5r4 124 12 ) ) -RRB- cord-302215-sqrbj5r4 124 13 have have VBP cord-302215-sqrbj5r4 124 14 been be VBN cord-302215-sqrbj5r4 124 15 clinically clinically RB cord-302215-sqrbj5r4 124 16 tested test VBN cord-302215-sqrbj5r4 124 17 for for IN cord-302215-sqrbj5r4 124 18 their -PRON- PRP$ cord-302215-sqrbj5r4 124 19 anti anti JJ cord-302215-sqrbj5r4 124 20 - - JJ cord-302215-sqrbj5r4 124 21 HIV hiv JJ cord-302215-sqrbj5r4 124 22 activity activity NN cord-302215-sqrbj5r4 124 23 [ [ -LRB- cord-302215-sqrbj5r4 124 24 3 3 CD cord-302215-sqrbj5r4 124 25 , , , cord-302215-sqrbj5r4 124 26 29 29 CD cord-302215-sqrbj5r4 124 27 ] ] -RRB- cord-302215-sqrbj5r4 124 28 . . . cord-302215-sqrbj5r4 125 1 Hydroxychloroquine Hydroxychloroquine NNP cord-302215-sqrbj5r4 125 2 is be VBZ cord-302215-sqrbj5r4 125 3 also also RB cord-302215-sqrbj5r4 125 4 recommended recommend VBN cord-302215-sqrbj5r4 125 5 to to TO cord-302215-sqrbj5r4 125 6 treat treat VB cord-302215-sqrbj5r4 125 7 lupus lupus NN cord-302215-sqrbj5r4 125 8 erythematosus erythematosus NN cord-302215-sqrbj5r4 125 9 and and CC cord-302215-sqrbj5r4 125 10 rheumatoid rheumatoid NN cord-302215-sqrbj5r4 125 11 arthritis arthritis NN cord-302215-sqrbj5r4 125 12 [ [ -LRB- cord-302215-sqrbj5r4 125 13 30 30 CD cord-302215-sqrbj5r4 125 14 ] ] -RRB- cord-302215-sqrbj5r4 125 15 . . . cord-302215-sqrbj5r4 126 1 Hydroxychloroquine Hydroxychloroquine NNP cord-302215-sqrbj5r4 126 2 and and CC cord-302215-sqrbj5r4 126 3 chloroquine chloroquine NN cord-302215-sqrbj5r4 126 4 , , , cord-302215-sqrbj5r4 126 5 eventually eventually RB cord-302215-sqrbj5r4 126 6 associated associate VBD cord-302215-sqrbj5r4 126 7 with with IN cord-302215-sqrbj5r4 126 8 an an DT cord-302215-sqrbj5r4 126 9 antibiotic antibiotic NN cord-302215-sqrbj5r4 126 10 , , , cord-302215-sqrbj5r4 126 11 are be VBP cord-302215-sqrbj5r4 126 12 the the DT cord-302215-sqrbj5r4 126 13 subjects subject NNS cord-302215-sqrbj5r4 126 14 of of IN cord-302215-sqrbj5r4 126 15 many many JJ cord-302215-sqrbj5r4 126 16 contradictory contradictory JJ cord-302215-sqrbj5r4 126 17 reports report NNS cord-302215-sqrbj5r4 126 18 about about IN cord-302215-sqrbj5r4 126 19 their -PRON- PRP$ cord-302215-sqrbj5r4 126 20 usefulness usefulness NN cord-302215-sqrbj5r4 126 21 in in IN cord-302215-sqrbj5r4 126 22 the the DT cord-302215-sqrbj5r4 126 23 treatment treatment NN cord-302215-sqrbj5r4 126 24 of of IN cord-302215-sqrbj5r4 126 25 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 126 26 . . . cord-302215-sqrbj5r4 127 1 Positive positive JJ cord-302215-sqrbj5r4 127 2 effects effect NNS cord-302215-sqrbj5r4 127 3 with with IN cord-302215-sqrbj5r4 127 4 viral viral JJ cord-302215-sqrbj5r4 127 5 clearance clearance NN cord-302215-sqrbj5r4 127 6 have have VBP cord-302215-sqrbj5r4 127 7 been be VBN cord-302215-sqrbj5r4 127 8 observed observe VBN cord-302215-sqrbj5r4 127 9 whereas whereas IN cord-302215-sqrbj5r4 127 10 other other JJ cord-302215-sqrbj5r4 127 11 groups group NNS cord-302215-sqrbj5r4 127 12 concluded conclude VBD cord-302215-sqrbj5r4 127 13 at at IN cord-302215-sqrbj5r4 127 14 the the DT cord-302215-sqrbj5r4 127 15 absence absence NN cord-302215-sqrbj5r4 127 16 of of IN cord-302215-sqrbj5r4 127 17 efficacy efficacy NN cord-302215-sqrbj5r4 127 18 or or CC cord-302215-sqrbj5r4 127 19 at at IN cord-302215-sqrbj5r4 127 20 cardiotoxicity cardiotoxicity NN cord-302215-sqrbj5r4 127 21 when when WRB cord-302215-sqrbj5r4 127 22 compared compare VBN cord-302215-sqrbj5r4 127 23 with with IN cord-302215-sqrbj5r4 127 24 standard standard JJ cord-302215-sqrbj5r4 127 25 care care NN cord-302215-sqrbj5r4 127 26 . . . cord-302215-sqrbj5r4 128 1 Discussions discussion NNS cord-302215-sqrbj5r4 128 2 are be VBP cord-302215-sqrbj5r4 128 3 articulated articulate VBN cord-302215-sqrbj5r4 128 4 among among IN cord-302215-sqrbj5r4 128 5 four four CD cord-302215-sqrbj5r4 128 6 main main JJ cord-302215-sqrbj5r4 128 7 aspects aspect NNS cord-302215-sqrbj5r4 128 8 that that WDT cord-302215-sqrbj5r4 128 9 should should MD cord-302215-sqrbj5r4 128 10 be be VB cord-302215-sqrbj5r4 128 11 taken take VBN cord-302215-sqrbj5r4 128 12 in in IN cord-302215-sqrbj5r4 128 13 account account NN cord-302215-sqrbj5r4 128 14 : : : cord-302215-sqrbj5r4 128 15 ( ( -LRB- cord-302215-sqrbj5r4 128 16 i i NN cord-302215-sqrbj5r4 128 17 ) ) -RRB- cord-302215-sqrbj5r4 128 18 stage stage NN cord-302215-sqrbj5r4 128 19 of of IN cord-302215-sqrbj5r4 128 20 the the DT cord-302215-sqrbj5r4 128 21 disease disease NN cord-302215-sqrbj5r4 128 22 ; ; . cord-302215-sqrbj5r4 129 1 ( ( -LRB- cord-302215-sqrbj5r4 129 2 ii ii LS cord-302215-sqrbj5r4 129 3 ) ) -RRB- cord-302215-sqrbj5r4 129 4 presence presence NN cord-302215-sqrbj5r4 129 5 / / SYM cord-302215-sqrbj5r4 129 6 absence absence NN cord-302215-sqrbj5r4 129 7 of of IN cord-302215-sqrbj5r4 129 8 a a DT cord-302215-sqrbj5r4 129 9 control control NN cord-302215-sqrbj5r4 129 10 group group NN cord-302215-sqrbj5r4 130 1 ; ; : cord-302215-sqrbj5r4 130 2 ( ( -LRB- cord-302215-sqrbj5r4 130 3 iii iii NN cord-302215-sqrbj5r4 130 4 ) ) -RRB- cord-302215-sqrbj5r4 130 5 efficacy efficacy NN cord-302215-sqrbj5r4 130 6 ; ; : cord-302215-sqrbj5r4 130 7 ( ( -LRB- cord-302215-sqrbj5r4 130 8 iv iv LS cord-302215-sqrbj5r4 130 9 ) ) -RRB- cord-302215-sqrbj5r4 130 10 safety safety NN cord-302215-sqrbj5r4 130 11 . . . cord-302215-sqrbj5r4 131 1 As as IN cord-302215-sqrbj5r4 131 2 earlier early RBR cord-302215-sqrbj5r4 131 3 mentioned mention VBN cord-302215-sqrbj5r4 131 4 , , , cord-302215-sqrbj5r4 131 5 controversial controversial JJ cord-302215-sqrbj5r4 131 6 results result NNS cord-302215-sqrbj5r4 131 7 have have VBP cord-302215-sqrbj5r4 131 8 been be VBN cord-302215-sqrbj5r4 131 9 published publish VBN cord-302215-sqrbj5r4 131 10 on on IN cord-302215-sqrbj5r4 131 11 the the DT cord-302215-sqrbj5r4 131 12 efficacy efficacy NN cord-302215-sqrbj5r4 131 13 of of IN cord-302215-sqrbj5r4 131 14 treatments treatment NNS cord-302215-sqrbj5r4 131 15 associating associate VBG cord-302215-sqrbj5r4 131 16 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 131 17 and and CC cord-302215-sqrbj5r4 131 18 azithromycin azithromycin NN cord-302215-sqrbj5r4 131 19 for for IN cord-302215-sqrbj5r4 131 20 French french JJ cord-302215-sqrbj5r4 131 21 patients patient NNS cord-302215-sqrbj5r4 131 22 hospitalized hospitalize VBN cord-302215-sqrbj5r4 131 23 for for IN cord-302215-sqrbj5r4 131 24 moderate moderate JJ cord-302215-sqrbj5r4 131 25 [ [ -LRB- cord-302215-sqrbj5r4 131 26 31 31 CD cord-302215-sqrbj5r4 131 27 ] ] -RRB- cord-302215-sqrbj5r4 131 28 or or CC cord-302215-sqrbj5r4 131 29 severe severe JJ cord-302215-sqrbj5r4 131 30 [ [ -LRB- cord-302215-sqrbj5r4 131 31 32 32 CD cord-302215-sqrbj5r4 131 32 , , , cord-302215-sqrbj5r4 131 33 33 33 CD cord-302215-sqrbj5r4 131 34 ] ] -RRB- cord-302215-sqrbj5r4 132 1 COVID-19 covid-19 JJ cord-302215-sqrbj5r4 132 2 infection infection NN cord-302215-sqrbj5r4 132 3 . . . cord-302215-sqrbj5r4 133 1 Another another DT cord-302215-sqrbj5r4 133 2 trial trial NN cord-302215-sqrbj5r4 133 3 [ [ -LRB- cord-302215-sqrbj5r4 133 4 34 34 CD cord-302215-sqrbj5r4 133 5 ] ] -RRB- cord-302215-sqrbj5r4 133 6 , , , cord-302215-sqrbj5r4 133 7 involving involve VBG cord-302215-sqrbj5r4 133 8 male male JJ cord-302215-sqrbj5r4 133 9 patients patient NNS cord-302215-sqrbj5r4 133 10 only only RB cord-302215-sqrbj5r4 133 11 at at IN cord-302215-sqrbj5r4 133 12 US US NNP cord-302215-sqrbj5r4 133 13 Veterans Veterans NNPS cord-302215-sqrbj5r4 133 14 Health Health NNP cord-302215-sqrbj5r4 133 15 Administration Administration NNP cord-302215-sqrbj5r4 133 16 medical medical JJ cord-302215-sqrbj5r4 133 17 centers center NNS cord-302215-sqrbj5r4 133 18 , , , cord-302215-sqrbj5r4 133 19 suggested suggest VBD cord-302215-sqrbj5r4 133 20 caution caution NN cord-302215-sqrbj5r4 133 21 in in IN cord-302215-sqrbj5r4 133 22 using use VBG cord-302215-sqrbj5r4 133 23 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 133 24 , , , cord-302215-sqrbj5r4 133 25 particularly particularly RB cord-302215-sqrbj5r4 133 26 when when WRB cord-302215-sqrbj5r4 133 27 not not RB cord-302215-sqrbj5r4 133 28 combined combine VBN cord-302215-sqrbj5r4 133 29 with with IN cord-302215-sqrbj5r4 133 30 azithromycin azithromycin NNP cord-302215-sqrbj5r4 133 31 . . . cord-302215-sqrbj5r4 134 1 Regarding regard VBG cord-302215-sqrbj5r4 134 2 cardiotoxicity cardiotoxicity NN cord-302215-sqrbj5r4 134 3 , , , cord-302215-sqrbj5r4 134 4 it -PRON- PRP cord-302215-sqrbj5r4 134 5 was be VBD cord-302215-sqrbj5r4 134 6 attributed attribute VBN cord-302215-sqrbj5r4 134 7 either either CC cord-302215-sqrbj5r4 134 8 to to IN cord-302215-sqrbj5r4 134 9 the the DT cord-302215-sqrbj5r4 134 10 combination combination NN cord-302215-sqrbj5r4 134 11 of of IN cord-302215-sqrbj5r4 134 12 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 134 13 and and CC cord-302215-sqrbj5r4 134 14 azithromycin azithromycin NNP cord-302215-sqrbj5r4 134 15 or or CC cord-302215-sqrbj5r4 134 16 to to IN cord-302215-sqrbj5r4 134 17 each each DT cord-302215-sqrbj5r4 134 18 of of IN cord-302215-sqrbj5r4 134 19 those those DT cord-302215-sqrbj5r4 134 20 two two CD cord-302215-sqrbj5r4 134 21 drugs drug NNS cord-302215-sqrbj5r4 134 22 independently independently RB cord-302215-sqrbj5r4 134 23 . . . cord-302215-sqrbj5r4 135 1 Thus thus RB cord-302215-sqrbj5r4 135 2 , , , cord-302215-sqrbj5r4 135 3 a a DT cord-302215-sqrbj5r4 135 4 study study NN cord-302215-sqrbj5r4 135 5 [ [ -LRB- cord-302215-sqrbj5r4 135 6 35 35 CD cord-302215-sqrbj5r4 135 7 ] ] -RRB- cord-302215-sqrbj5r4 135 8 indicated indicate VBD cord-302215-sqrbj5r4 135 9 that that IN cord-302215-sqrbj5r4 135 10 , , , cord-302215-sqrbj5r4 135 11 for for IN cord-302215-sqrbj5r4 135 12 patients patient NNS cord-302215-sqrbj5r4 135 13 treated treat VBN cord-302215-sqrbj5r4 135 14 with with IN cord-302215-sqrbj5r4 135 15 the the DT cord-302215-sqrbj5r4 135 16 combination combination NN cord-302215-sqrbj5r4 135 17 , , , cord-302215-sqrbj5r4 135 18 critical critical JJ cord-302215-sqrbj5r4 135 19 corrected correct VBN cord-302215-sqrbj5r4 135 20 QT QT NNP cord-302215-sqrbj5r4 135 21 interval interval NN cord-302215-sqrbj5r4 135 22 prolongations prolongation NNS cord-302215-sqrbj5r4 135 23 were be VBD cord-302215-sqrbj5r4 135 24 higher high JJR cord-302215-sqrbj5r4 135 25 than than IN cord-302215-sqrbj5r4 135 26 for for IN cord-302215-sqrbj5r4 135 27 patients patient NNS cord-302215-sqrbj5r4 135 28 treated treat VBN cord-302215-sqrbj5r4 135 29 with with IN cord-302215-sqrbj5r4 135 30 the the DT cord-302215-sqrbj5r4 135 31 antibiotic antibiotic NN cord-302215-sqrbj5r4 135 32 alone alone RB cord-302215-sqrbj5r4 135 33 . . . cord-302215-sqrbj5r4 136 1 This this DT cord-302215-sqrbj5r4 136 2 contrasts contrast VBZ cord-302215-sqrbj5r4 136 3 with with IN cord-302215-sqrbj5r4 136 4 the the DT cord-302215-sqrbj5r4 136 5 conclusion conclusion NN cord-302215-sqrbj5r4 136 6 of of IN cord-302215-sqrbj5r4 136 7 J.C.E. J.C.E. NNP cord-302215-sqrbj5r4 136 8 Lane Lane NNP cord-302215-sqrbj5r4 136 9 et et NNP cord-302215-sqrbj5r4 136 10 al al NNP cord-302215-sqrbj5r4 136 11 . . . cord-302215-sqrbj5r4 137 1 [ [ -LRB- cord-302215-sqrbj5r4 137 2 36 36 CD cord-302215-sqrbj5r4 137 3 ] ] -RRB- cord-302215-sqrbj5r4 137 4 who who WP cord-302215-sqrbj5r4 137 5 reported report VBD cord-302215-sqrbj5r4 137 6 that that IN cord-302215-sqrbj5r4 137 7 " " `` cord-302215-sqrbj5r4 137 8 short short JJ cord-302215-sqrbj5r4 137 9 - - HYPH cord-302215-sqrbj5r4 137 10 term term NN cord-302215-sqrbj5r4 137 11 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 137 12 treatment treatment NN cord-302215-sqrbj5r4 137 13 is be VBZ cord-302215-sqrbj5r4 137 14 safe safe JJ cord-302215-sqrbj5r4 137 15 , , , cord-302215-sqrbj5r4 137 16 but but CC cord-302215-sqrbj5r4 137 17 addition addition NN cord-302215-sqrbj5r4 137 18 of of IN cord-302215-sqrbj5r4 137 19 azithromycin azithromycin NNP cord-302215-sqrbj5r4 137 20 may may MD cord-302215-sqrbj5r4 137 21 induce induce VB cord-302215-sqrbj5r4 137 22 heart heart NN cord-302215-sqrbj5r4 137 23 failure failure NN cord-302215-sqrbj5r4 137 24 and and CC cord-302215-sqrbj5r4 137 25 cardiovascular cardiovascular JJ cord-302215-sqrbj5r4 137 26 mortality mortality NN cord-302215-sqrbj5r4 137 27 , , , cord-302215-sqrbj5r4 137 28 potentially potentially RB cord-302215-sqrbj5r4 137 29 due due JJ cord-302215-sqrbj5r4 137 30 to to IN cord-302215-sqrbj5r4 137 31 synergistic synergistic JJ cord-302215-sqrbj5r4 137 32 effects effect NNS cord-302215-sqrbj5r4 137 33 on on IN cord-302215-sqrbj5r4 137 34 QT qt NN cord-302215-sqrbj5r4 137 35 length length NN cord-302215-sqrbj5r4 137 36 . . . cord-302215-sqrbj5r4 138 1 " " `` cord-302215-sqrbj5r4 138 2 On on IN cord-302215-sqrbj5r4 138 3 the the DT cord-302215-sqrbj5r4 138 4 other other JJ cord-302215-sqrbj5r4 138 5 hand hand NN cord-302215-sqrbj5r4 138 6 , , , cord-302215-sqrbj5r4 138 7 data datum NNS cord-302215-sqrbj5r4 138 8 [ [ -LRB- cord-302215-sqrbj5r4 138 9 37 37 CD cord-302215-sqrbj5r4 138 10 ] ] -RRB- cord-302215-sqrbj5r4 138 11 collected collect VBN cord-302215-sqrbj5r4 138 12 from from IN cord-302215-sqrbj5r4 138 13 four four CD cord-302215-sqrbj5r4 138 14 French french JJ cord-302215-sqrbj5r4 138 15 hospitals hospital NNS cord-302215-sqrbj5r4 138 16 revealed reveal VBD cord-302215-sqrbj5r4 138 17 that that IN cord-302215-sqrbj5r4 138 18 patients patient NNS cord-302215-sqrbj5r4 138 19 receiving receive VBG cord-302215-sqrbj5r4 138 20 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 138 21 experienced experience VBD cord-302215-sqrbj5r4 138 22 electrocardiogram electrocardiogram NN cord-302215-sqrbj5r4 138 23 modifications modification NNS cord-302215-sqrbj5r4 138 24 requiring require VBG cord-302215-sqrbj5r4 138 25 discontinuation discontinuation NN cord-302215-sqrbj5r4 138 26 of of IN cord-302215-sqrbj5r4 138 27 the the DT cord-302215-sqrbj5r4 138 28 treatment treatment NN cord-302215-sqrbj5r4 138 29 with with IN cord-302215-sqrbj5r4 138 30 that that DT cord-302215-sqrbj5r4 138 31 molecule molecule NN cord-302215-sqrbj5r4 138 32 . . . cord-302215-sqrbj5r4 139 1 In in IN cord-302215-sqrbj5r4 139 2 the the DT cord-302215-sqrbj5r4 139 3 case case NN cord-302215-sqrbj5r4 139 4 of of IN cord-302215-sqrbj5r4 139 5 chloroquine chloroquine NN cord-302215-sqrbj5r4 139 6 , , , cord-302215-sqrbj5r4 139 7 studies study NNS cord-302215-sqrbj5r4 139 8 on on IN cord-302215-sqrbj5r4 139 9 dose dose NN cord-302215-sqrbj5r4 139 10 - - HYPH cord-302215-sqrbj5r4 139 11 dependence dependence NN cord-302215-sqrbj5r4 139 12 safety safety NN cord-302215-sqrbj5r4 139 13 can can MD cord-302215-sqrbj5r4 139 14 be be VB cord-302215-sqrbj5r4 139 15 found find VBN cord-302215-sqrbj5r4 139 16 . . . cord-302215-sqrbj5r4 140 1 A a DT cord-302215-sqrbj5r4 140 2 Brazilian brazilian JJ cord-302215-sqrbj5r4 140 3 trial trial NN cord-302215-sqrbj5r4 140 4 [ [ -LRB- cord-302215-sqrbj5r4 140 5 38 38 CD cord-302215-sqrbj5r4 140 6 ] ] -RRB- cord-302215-sqrbj5r4 140 7 revealed reveal VBD cord-302215-sqrbj5r4 140 8 that that IN cord-302215-sqrbj5r4 140 9 treatment treatment NN cord-302215-sqrbj5r4 140 10 had have VBD cord-302215-sqrbj5r4 140 11 to to TO cord-302215-sqrbj5r4 140 12 be be VB cord-302215-sqrbj5r4 140 13 interrupted interrupt VBN cord-302215-sqrbj5r4 140 14 for for IN cord-302215-sqrbj5r4 140 15 a a DT cord-302215-sqrbj5r4 140 16 cohort cohort NN cord-302215-sqrbj5r4 140 17 of of IN cord-302215-sqrbj5r4 140 18 patients patient NNS cord-302215-sqrbj5r4 140 19 allocated allocate VBN cord-302215-sqrbj5r4 140 20 to to TO cord-302215-sqrbj5r4 140 21 receive receive VB cord-302215-sqrbj5r4 140 22 a a DT cord-302215-sqrbj5r4 140 23 total total JJ cord-302215-sqrbj5r4 140 24 dose dose NN cord-302215-sqrbj5r4 140 25 of of IN cord-302215-sqrbj5r4 140 26 chloroquine chloroquine NN cord-302215-sqrbj5r4 140 27 of of IN cord-302215-sqrbj5r4 140 28 12 12 CD cord-302215-sqrbj5r4 140 29 g g NN cord-302215-sqrbj5r4 140 30 , , , cord-302215-sqrbj5r4 140 31 4-fold 4-fold IN cord-302215-sqrbj5r4 140 32 the the DT cord-302215-sqrbj5r4 140 33 dosage dosage NN cord-302215-sqrbj5r4 140 34 recommended recommend VBN cord-302215-sqrbj5r4 140 35 in in IN cord-302215-sqrbj5r4 140 36 the the DT cord-302215-sqrbj5r4 140 37 Discovery Discovery NNP cord-302215-sqrbj5r4 140 38 project project NN cord-302215-sqrbj5r4 140 39 . . . cord-302215-sqrbj5r4 141 1 The the DT cord-302215-sqrbj5r4 141 2 results result NNS cord-302215-sqrbj5r4 141 3 were be VBD cord-302215-sqrbj5r4 141 4 confirmed confirm VBN cord-302215-sqrbj5r4 141 5 in in IN cord-302215-sqrbj5r4 141 6 a a DT cord-302215-sqrbj5r4 141 7 French french JJ cord-302215-sqrbj5r4 141 8 study study NN cord-302215-sqrbj5r4 141 9 [ [ -LRB- cord-302215-sqrbj5r4 141 10 39 39 CD cord-302215-sqrbj5r4 141 11 ] ] -RRB- cord-302215-sqrbj5r4 141 12 that that WDT cord-302215-sqrbj5r4 141 13 concluded conclude VBD cord-302215-sqrbj5r4 141 14 that that IN cord-302215-sqrbj5r4 141 15 " " `` cord-302215-sqrbj5r4 141 16 high high JJ cord-302215-sqrbj5r4 141 17 - - HYPH cord-302215-sqrbj5r4 141 18 dose dose NN cord-302215-sqrbj5r4 141 19 chloroquine chloroquine NN cord-302215-sqrbj5r4 141 20 treatment treatment NN cord-302215-sqrbj5r4 141 21 regimens regimen NNS cord-302215-sqrbj5r4 141 22 which which WDT cord-302215-sqrbj5r4 141 23 result result VBP cord-302215-sqrbj5r4 141 24 in in IN cord-302215-sqrbj5r4 141 25 whole whole JJ cord-302215-sqrbj5r4 141 26 blood blood NN cord-302215-sqrbj5r4 141 27 chloroquine chloroquine NN cord-302215-sqrbj5r4 141 28 concentrations concentration NNS cord-302215-sqrbj5r4 141 29 below below IN cord-302215-sqrbj5r4 141 30 10µmol 10µmol JJ cord-302215-sqrbj5r4 141 31 / / SYM cord-302215-sqrbj5r4 141 32 L l NN cord-302215-sqrbj5r4 141 33 for for IN cord-302215-sqrbj5r4 141 34 the the DT cord-302215-sqrbj5r4 141 35 majority majority NN cord-302215-sqrbj5r4 141 36 of of IN cord-302215-sqrbj5r4 141 37 patients patient NNS cord-302215-sqrbj5r4 141 38 should should MD cord-302215-sqrbj5r4 141 39 not not RB cord-302215-sqrbj5r4 141 40 result result VB cord-302215-sqrbj5r4 141 41 in in IN cord-302215-sqrbj5r4 141 42 life life NN cord-302215-sqrbj5r4 141 43 - - HYPH cord-302215-sqrbj5r4 141 44 threatening threaten VBG cord-302215-sqrbj5r4 141 45 cardiovascular cardiovascular JJ cord-302215-sqrbj5r4 141 46 toxicity toxicity NN cord-302215-sqrbj5r4 141 47 . . . cord-302215-sqrbj5r4 142 1 " " '' cord-302215-sqrbj5r4 143 1 All all PDT cord-302215-sqrbj5r4 143 2 those those DT cord-302215-sqrbj5r4 143 3 observations observation NNS cord-302215-sqrbj5r4 143 4 confirm confirm VBP cord-302215-sqrbj5r4 143 5 a a DT cord-302215-sqrbj5r4 143 6 recent recent JJ cord-302215-sqrbj5r4 143 7 theoretical theoretical JJ cord-302215-sqrbj5r4 143 8 model model NN cord-302215-sqrbj5r4 143 9 that that WDT cord-302215-sqrbj5r4 143 10 attracted attract VBD cord-302215-sqrbj5r4 143 11 attention attention NN cord-302215-sqrbj5r4 143 12 to to IN cord-302215-sqrbj5r4 143 13 the the DT cord-302215-sqrbj5r4 143 14 fact fact NN cord-302215-sqrbj5r4 143 15 that that IN cord-302215-sqrbj5r4 143 16 both both CC cord-302215-sqrbj5r4 143 17 hydroxychloroquine hydroxychloroquine NNP cord-302215-sqrbj5r4 143 18 and and CC cord-302215-sqrbj5r4 143 19 chloroquine chloroquine NNP cord-302215-sqrbj5r4 143 20 were be VBD cord-302215-sqrbj5r4 143 21 characterized characterize VBN cord-302215-sqrbj5r4 143 22 by by IN cord-302215-sqrbj5r4 143 23 narrow narrow JJ cord-302215-sqrbj5r4 143 24 therapeutic therapeutic JJ cord-302215-sqrbj5r4 143 25 windows window NNS cord-302215-sqrbj5r4 143 26 overlapping overlap VBG cord-302215-sqrbj5r4 143 27 with with IN cord-302215-sqrbj5r4 143 28 the the DT cord-302215-sqrbj5r4 143 29 highest high JJS cord-302215-sqrbj5r4 143 30 tolerated tolerate VBN cord-302215-sqrbj5r4 143 31 doses dose NNS cord-302215-sqrbj5r4 143 32 [ [ -LRB- cord-302215-sqrbj5r4 143 33 40 40 CD cord-302215-sqrbj5r4 143 34 ] ] -RRB- cord-302215-sqrbj5r4 143 35 . . . cord-302215-sqrbj5r4 144 1 The the DT cord-302215-sqrbj5r4 144 2 problem problem NN cord-302215-sqrbj5r4 144 3 could could MD cord-302215-sqrbj5r4 144 4 be be VB cord-302215-sqrbj5r4 144 5 overcome overcome VBN cord-302215-sqrbj5r4 144 6 by by IN cord-302215-sqrbj5r4 144 7 using use VBG cord-302215-sqrbj5r4 144 8 the the DT cord-302215-sqrbj5r4 144 9 medications medication NNS cord-302215-sqrbj5r4 144 10 as as IN cord-302215-sqrbj5r4 144 11 an an DT cord-302215-sqrbj5r4 144 12 aerosol aerosol NN cord-302215-sqrbj5r4 144 13 as as IN cord-302215-sqrbj5r4 144 14 suggested suggest VBN cord-302215-sqrbj5r4 144 15 by by IN cord-302215-sqrbj5r4 144 16 Klimke Klimke NNP cord-302215-sqrbj5r4 144 17 et et FW cord-302215-sqrbj5r4 144 18 al al NNP cord-302215-sqrbj5r4 144 19 . . . cord-302215-sqrbj5r4 145 1 [ [ -LRB- cord-302215-sqrbj5r4 145 2 41 41 CD cord-302215-sqrbj5r4 145 3 ] ] -RRB- cord-302215-sqrbj5r4 145 4 . . . cord-302215-sqrbj5r4 146 1 As as IN cord-302215-sqrbj5r4 146 2 of of IN cord-302215-sqrbj5r4 146 3 May May NNP cord-302215-sqrbj5r4 146 4 4 4 CD cord-302215-sqrbj5r4 146 5 , , , cord-302215-sqrbj5r4 146 6 there there EX cord-302215-sqrbj5r4 146 7 are be VBP cord-302215-sqrbj5r4 146 8 1133 1133 CD cord-302215-sqrbj5r4 146 9 clinical clinical JJ cord-302215-sqrbj5r4 146 10 trials trial NNS cord-302215-sqrbj5r4 146 11 on on IN cord-302215-sqrbj5r4 146 12 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 146 13 that that WDT cord-302215-sqrbj5r4 146 14 are be VBP cord-302215-sqrbj5r4 146 15 referenced reference VBN cord-302215-sqrbj5r4 146 16 in in IN cord-302215-sqrbj5r4 146 17 the the DT cord-302215-sqrbj5r4 146 18 U.S. U.S. NNP cord-302215-sqrbj5r4 146 19 National National NNP cord-302215-sqrbj5r4 146 20 Library Library NNP cord-302215-sqrbj5r4 146 21 of of IN cord-302215-sqrbj5r4 146 22 Medicine Medicine NNP cord-302215-sqrbj5r4 146 23 of of IN cord-302215-sqrbj5r4 146 24 the the DT cord-302215-sqrbj5r4 146 25 National National NNP cord-302215-sqrbj5r4 146 26 Institutes Institutes NNPS cord-302215-sqrbj5r4 146 27 of of IN cord-302215-sqrbj5r4 146 28 Health Health NNP cord-302215-sqrbj5r4 146 29 [ [ -LRB- cord-302215-sqrbj5r4 146 30 3 3 CD cord-302215-sqrbj5r4 146 31 ] ] -RRB- cord-302215-sqrbj5r4 146 32 . . . cord-302215-sqrbj5r4 147 1 The the DT cord-302215-sqrbj5r4 147 2 most most RBS cord-302215-sqrbj5r4 147 3 considered consider VBN cord-302215-sqrbj5r4 147 4 potential potential JJ cord-302215-sqrbj5r4 147 5 treatments treatment NNS cord-302215-sqrbj5r4 147 6 are be VBP cord-302215-sqrbj5r4 147 7 centered center VBN cord-302215-sqrbj5r4 147 8 on on IN cord-302215-sqrbj5r4 147 9 plasma plasma NN cord-302215-sqrbj5r4 147 10 therapy therapy NN cord-302215-sqrbj5r4 147 11 and and CC cord-302215-sqrbj5r4 147 12 evaluation evaluation NN cord-302215-sqrbj5r4 147 13 of of IN cord-302215-sqrbj5r4 147 14 the the DT cord-302215-sqrbj5r4 147 15 potentialities potentiality NNS cord-302215-sqrbj5r4 147 16 of of IN cord-302215-sqrbj5r4 147 17 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 147 18 , , , cord-302215-sqrbj5r4 147 19 chloroquine chloroquine NN cord-302215-sqrbj5r4 147 20 , , , cord-302215-sqrbj5r4 147 21 and and CC cord-302215-sqrbj5r4 147 22 the the DT cord-302215-sqrbj5r4 147 23 combination combination NN cord-302215-sqrbj5r4 147 24 lopinavir lopinavir NNP cord-302215-sqrbj5r4 147 25 / / SYM cord-302215-sqrbj5r4 147 26 ritonavir ritonavir NNS cord-302215-sqrbj5r4 147 27 . . . cord-302215-sqrbj5r4 148 1 Protein protein NN cord-302215-sqrbj5r4 148 2 and and CC cord-302215-sqrbj5r4 148 3 cell cell NN cord-302215-sqrbj5r4 148 4 therapies therapy NNS cord-302215-sqrbj5r4 148 5 attract attract VBP cord-302215-sqrbj5r4 148 6 less less JJR cord-302215-sqrbj5r4 148 7 interest interest NN cord-302215-sqrbj5r4 148 8 , , , cord-302215-sqrbj5r4 148 9 despite despite IN cord-302215-sqrbj5r4 148 10 their -PRON- PRP$ cord-302215-sqrbj5r4 148 11 high high JJ cord-302215-sqrbj5r4 148 12 promises promise NNS cord-302215-sqrbj5r4 148 13 in in IN cord-302215-sqrbj5r4 148 14 other other JJ cord-302215-sqrbj5r4 148 15 diseases disease NNS cord-302215-sqrbj5r4 148 16 . . . cord-302215-sqrbj5r4 149 1 The the DT cord-302215-sqrbj5r4 149 2 antiviral antiviral JJ cord-302215-sqrbj5r4 149 3 agent agent NN cord-302215-sqrbj5r4 149 4 remdesivir remdesivir NNP cord-302215-sqrbj5r4 149 5 exerts exert VBZ cord-302215-sqrbj5r4 149 6 a a DT cord-302215-sqrbj5r4 149 7 moderate moderate JJ cord-302215-sqrbj5r4 149 8 focus focus NN cord-302215-sqrbj5r4 149 9 in in IN cord-302215-sqrbj5r4 149 10 the the DT cord-302215-sqrbj5r4 149 11 medical medical JJ cord-302215-sqrbj5r4 149 12 community community NN cord-302215-sqrbj5r4 149 13 , , , cord-302215-sqrbj5r4 149 14 despite despite IN cord-302215-sqrbj5r4 149 15 a a DT cord-302215-sqrbj5r4 149 16 large large JJ cord-302215-sqrbj5r4 149 17 mediatic mediatic JJ cord-302215-sqrbj5r4 149 18 audience audience NN cord-302215-sqrbj5r4 149 19 . . . cord-302215-sqrbj5r4 150 1 Great great JJ cord-302215-sqrbj5r4 150 2 hope hope NN cord-302215-sqrbj5r4 150 3 had have VBD cord-302215-sqrbj5r4 150 4 been be VBN cord-302215-sqrbj5r4 150 5 put put VBN cord-302215-sqrbj5r4 150 6 in in IN cord-302215-sqrbj5r4 150 7 the the DT cord-302215-sqrbj5r4 150 8 European european JJ cord-302215-sqrbj5r4 150 9 trial trial NN cord-302215-sqrbj5r4 150 10 Discovery Discovery NNP cord-302215-sqrbj5r4 150 11 . . . cord-302215-sqrbj5r4 151 1 It -PRON- PRP cord-302215-sqrbj5r4 151 2 must must MD cord-302215-sqrbj5r4 151 3 be be VB cord-302215-sqrbj5r4 151 4 admitted admit VBN cord-302215-sqrbj5r4 151 5 , , , cord-302215-sqrbj5r4 151 6 however however RB cord-302215-sqrbj5r4 151 7 , , , cord-302215-sqrbj5r4 151 8 that that IN cord-302215-sqrbj5r4 151 9 the the DT cord-302215-sqrbj5r4 151 10 actual actual JJ cord-302215-sqrbj5r4 151 11 situation situation NN cord-302215-sqrbj5r4 151 12 is be VBZ cord-302215-sqrbj5r4 151 13 rather rather RB cord-302215-sqrbj5r4 151 14 disappointing disappointing JJ cord-302215-sqrbj5r4 151 15 since since IN cord-302215-sqrbj5r4 151 16 many many JJ cord-302215-sqrbj5r4 151 17 countries country NNS cord-302215-sqrbj5r4 151 18 are be VBP cord-302215-sqrbj5r4 151 19 not not RB cord-302215-sqrbj5r4 151 20 yet yet RB cord-302215-sqrbj5r4 151 21 enrolled enrol VBN cord-302215-sqrbj5r4 151 22 and and CC cord-302215-sqrbj5r4 151 23 consequently consequently RB cord-302215-sqrbj5r4 151 24 not not RB cord-302215-sqrbj5r4 151 25 recruiting recruit VBG cord-302215-sqrbj5r4 151 26 . . . cord-302215-sqrbj5r4 152 1 Results result NNS cord-302215-sqrbj5r4 152 2 on on IN cord-302215-sqrbj5r4 152 3 the the DT cord-302215-sqrbj5r4 152 4 efficacy efficacy NN cord-302215-sqrbj5r4 152 5 of of IN cord-302215-sqrbj5r4 152 6 remdesivir remdesivir NNP cord-302215-sqrbj5r4 152 7 are be VBP cord-302215-sqrbj5r4 152 8 fragmentary fragmentary JJ cord-302215-sqrbj5r4 152 9 and and CC cord-302215-sqrbj5r4 152 10 disclosed disclose VBN cord-302215-sqrbj5r4 152 11 by by IN cord-302215-sqrbj5r4 152 12 the the DT cord-302215-sqrbj5r4 152 13 manufacturer manufacturer NN cord-302215-sqrbj5r4 152 14 . . . cord-302215-sqrbj5r4 153 1 The the DT cord-302215-sqrbj5r4 153 2 combination combination NN cord-302215-sqrbj5r4 153 3 lopinavir lopinavir NNS cord-302215-sqrbj5r4 153 4 / / SYM cord-302215-sqrbj5r4 153 5 ritonavir ritonavir NNP cord-302215-sqrbj5r4 153 6 does do VBZ cord-302215-sqrbj5r4 153 7 not not RB cord-302215-sqrbj5r4 153 8 provide provide VB cord-302215-sqrbj5r4 153 9 promising promising JJ cord-302215-sqrbj5r4 153 10 curative curative JJ cord-302215-sqrbj5r4 153 11 effects effect NNS cord-302215-sqrbj5r4 153 12 . . . cord-302215-sqrbj5r4 154 1 In in IN cord-302215-sqrbj5r4 154 2 - - HYPH cord-302215-sqrbj5r4 154 3 depth depth NN cord-302215-sqrbj5r4 154 4 studies study NNS cord-302215-sqrbj5r4 154 5 are be VBP cord-302215-sqrbj5r4 154 6 still still RB cord-302215-sqrbj5r4 154 7 awaited await VBN cord-302215-sqrbj5r4 154 8 in in IN cord-302215-sqrbj5r4 154 9 order order NN cord-302215-sqrbj5r4 154 10 to to TO cord-302215-sqrbj5r4 154 11 clarify clarify VB cord-302215-sqrbj5r4 154 12 contradictory contradictory JJ cord-302215-sqrbj5r4 154 13 data datum NNS cord-302215-sqrbj5r4 154 14 on on IN cord-302215-sqrbj5r4 154 15 the the DT cord-302215-sqrbj5r4 154 16 usefulness usefulness NN cord-302215-sqrbj5r4 154 17 of of IN cord-302215-sqrbj5r4 154 18 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 154 19 and and CC cord-302215-sqrbj5r4 154 20 chloroquine chloroquine NNP cord-302215-sqrbj5r4 154 21 . . . cord-302215-sqrbj5r4 155 1 In in IN cord-302215-sqrbj5r4 155 2 conclusion conclusion NN cord-302215-sqrbj5r4 155 3 , , , cord-302215-sqrbj5r4 155 4 to to IN cord-302215-sqrbj5r4 155 5 date date NN cord-302215-sqrbj5r4 155 6 no no DT cord-302215-sqrbj5r4 155 7 treatment treatment NN cord-302215-sqrbj5r4 155 8 can can MD cord-302215-sqrbj5r4 155 9 be be VB cord-302215-sqrbj5r4 155 10 proposed propose VBN cord-302215-sqrbj5r4 155 11 despite despite IN cord-302215-sqrbj5r4 155 12 the the DT cord-302215-sqrbj5r4 155 13 urgency urgency NN cord-302215-sqrbj5r4 155 14 of of IN cord-302215-sqrbj5r4 155 15 the the DT cord-302215-sqrbj5r4 155 16 situation situation NN cord-302215-sqrbj5r4 155 17 . . . cord-302215-sqrbj5r4 156 1 Foundation Foundation NNP cord-302215-sqrbj5r4 156 2 and and CC cord-302215-sqrbj5r4 156 3 Partners Partners NNPS cord-302215-sqrbj5r4 156 4 Launch launch VBP cord-302215-sqrbj5r4 156 5 First first JJ cord-302215-sqrbj5r4 156 6 - - HYPH cord-302215-sqrbj5r4 156 7 of of IN cord-302215-sqrbj5r4 156 8 - - HYPH cord-302215-sqrbj5r4 156 9 Its -PRON- PRP$ cord-302215-sqrbj5r4 156 10 - - HYPH cord-302215-sqrbj5r4 156 11 Kind Kind NNP cord-302215-sqrbj5r4 156 12 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 156 13 Solidarity Solidarity NNP cord-302215-sqrbj5r4 156 14 Response Response NNP cord-302215-sqrbj5r4 156 15 Fund Fund NNP cord-302215-sqrbj5r4 156 16 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 156 17 : : : cord-302215-sqrbj5r4 156 18 A a DT cord-302215-sqrbj5r4 156 19 brief brief JJ cord-302215-sqrbj5r4 156 20 overview overview NN cord-302215-sqrbj5r4 156 21 of of IN cord-302215-sqrbj5r4 156 22 the the DT cord-302215-sqrbj5r4 156 23 Discovery Discovery NNP cord-302215-sqrbj5r4 156 24 clinical clinical JJ cord-302215-sqrbj5r4 156 25 trial trial NN cord-302215-sqrbj5r4 156 26 Chinese Chinese NNP cord-302215-sqrbj5r4 156 27 Clinical Clinical NNP cord-302215-sqrbj5r4 156 28 Trial Trial NNP cord-302215-sqrbj5r4 156 29 Registry Registry NNP cord-302215-sqrbj5r4 156 30 Trial Trial NNP cord-302215-sqrbj5r4 156 31 of of IN cord-302215-sqrbj5r4 156 32 Treatments Treatments NNP cord-302215-sqrbj5r4 156 33 for for IN cord-302215-sqrbj5r4 156 34 COVID-19 covid-19 CD cord-302215-sqrbj5r4 156 35 in in IN cord-302215-sqrbj5r4 156 36 Hospitalized Hospitalized NNP cord-302215-sqrbj5r4 156 37 Adults Adults NNPS cord-302215-sqrbj5r4 156 38 Les Les NNP cord-302215-sqrbj5r4 156 39 Essais Essais NNP cord-302215-sqrbj5r4 156 40 Cliniques clinique NNS cord-302215-sqrbj5r4 156 41 Pour Pour NNP cord-302215-sqrbj5r4 156 42 un un NNP cord-302215-sqrbj5r4 156 43 Traitement Traitement NNP cord-302215-sqrbj5r4 156 44 du du NNP cord-302215-sqrbj5r4 156 45 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 156 46 n'ont n'ont NNP cord-302215-sqrbj5r4 156 47 Toujours toujours FW cord-302215-sqrbj5r4 156 48 Pas pas NN cord-302215-sqrbj5r4 156 49 Débuté Débuté NNP cord-302215-sqrbj5r4 156 50 en en IN cord-302215-sqrbj5r4 156 51 Belgique Belgique NNP cord-302215-sqrbj5r4 156 52 Investigational Investigational NNP cord-302215-sqrbj5r4 156 53 Therapeutics Therapeutics NNP cord-302215-sqrbj5r4 156 54 for for IN cord-302215-sqrbj5r4 156 55 the the DT cord-302215-sqrbj5r4 156 56 Treatment Treatment NNP cord-302215-sqrbj5r4 156 57 of of IN cord-302215-sqrbj5r4 156 58 People People NNPS cord-302215-sqrbj5r4 156 59 with with IN cord-302215-sqrbj5r4 156 60 Ebola Ebola NNP cord-302215-sqrbj5r4 156 61 Virus Virus NNP cord-302215-sqrbj5r4 156 62 Disease Disease NNP cord-302215-sqrbj5r4 157 1 A a DT cord-302215-sqrbj5r4 157 2 randomized randomized JJ cord-302215-sqrbj5r4 157 3 , , , cord-302215-sqrbj5r4 157 4 controlled control VBN cord-302215-sqrbj5r4 157 5 trial trial NN cord-302215-sqrbj5r4 157 6 of of IN cord-302215-sqrbj5r4 157 7 Ebola Ebola NNP cord-302215-sqrbj5r4 157 8 virus virus NN cord-302215-sqrbj5r4 157 9 disease disease NN cord-302215-sqrbj5r4 157 10 therapeutics therapeutics NN cord-302215-sqrbj5r4 157 11 Search Search NNP cord-302215-sqrbj5r4 157 12 Orphan Orphan NNP cord-302215-sqrbj5r4 157 13 Drug Drug NNP cord-302215-sqrbj5r4 157 14 Designations Designations NNPS cord-302215-sqrbj5r4 157 15 and and CC cord-302215-sqrbj5r4 157 16 Approvals Approvals NNPS cord-302215-sqrbj5r4 157 17 . . . cord-302215-sqrbj5r4 158 1 Available available JJ cord-302215-sqrbj5r4 158 2 online online JJ cord-302215-sqrbj5r4 158 3 Search Search NNP cord-302215-sqrbj5r4 158 4 Orphan Orphan NNP cord-302215-sqrbj5r4 158 5 Drug Drug NNP cord-302215-sqrbj5r4 158 6 Designations Designations NNPS cord-302215-sqrbj5r4 158 7 and and CC cord-302215-sqrbj5r4 158 8 Approvals Approvals NNPS cord-302215-sqrbj5r4 158 9 . . . cord-302215-sqrbj5r4 159 1 Available available JJ cord-302215-sqrbj5r4 159 2 online online RB cord-302215-sqrbj5r4 159 3 Gilead Gilead NNP cord-302215-sqrbj5r4 159 4 Sciences Sciences NNPS cord-302215-sqrbj5r4 159 5 Statement Statement NNP cord-302215-sqrbj5r4 159 6 on on IN cord-302215-sqrbj5r4 159 7 Request request NN cord-302215-sqrbj5r4 159 8 to to TO cord-302215-sqrbj5r4 159 9 Rescind rescind VB cord-302215-sqrbj5r4 159 10 Remdesivir Remdesivir NNP cord-302215-sqrbj5r4 159 11 Orphan Orphan NNP cord-302215-sqrbj5r4 159 12 Drug Drug NNP cord-302215-sqrbj5r4 159 13 Designation Designation NNP cord-302215-sqrbj5r4 159 14 Expanded expand VBD cord-302215-sqrbj5r4 159 15 Access Access NNP cord-302215-sqrbj5r4 159 16 Remdesivir Remdesivir NNP cord-302215-sqrbj5r4 159 17 ( ( -LRB- cord-302215-sqrbj5r4 159 18 RDV RDV NNP cord-302215-sqrbj5r4 159 19 ; ; : cord-302215-sqrbj5r4 159 20 GS-5734 GS-5734 NNP cord-302215-sqrbj5r4 159 21 ™ ™ LS cord-302215-sqrbj5r4 159 22 ) ) -RRB- cord-302215-sqrbj5r4 160 1 First First NNP cord-302215-sqrbj5r4 160 2 Case Case NNP cord-302215-sqrbj5r4 160 3 of of IN cord-302215-sqrbj5r4 160 4 2019 2019 CD cord-302215-sqrbj5r4 160 5 Novel Novel NNP cord-302215-sqrbj5r4 160 6 Coronavirus Coronavirus NNP cord-302215-sqrbj5r4 160 7 in in IN cord-302215-sqrbj5r4 160 8 the the DT cord-302215-sqrbj5r4 160 9 United United NNP cord-302215-sqrbj5r4 160 10 States States NNP cord-302215-sqrbj5r4 160 11 Compassionate compassionate JJ cord-302215-sqrbj5r4 160 12 use use NN cord-302215-sqrbj5r4 160 13 of of IN cord-302215-sqrbj5r4 160 14 remdesivir remdesivir NNS cord-302215-sqrbj5r4 160 15 for for IN cord-302215-sqrbj5r4 160 16 patients patient NNS cord-302215-sqrbj5r4 160 17 with with IN cord-302215-sqrbj5r4 160 18 severe severe JJ cord-302215-sqrbj5r4 160 19 Covid-19 Covid-19 NNP cord-302215-sqrbj5r4 160 20 Expanded expand VBN cord-302215-sqrbj5r4 160 21 Access Access NNP cord-302215-sqrbj5r4 160 22 Treatment Treatment NNP cord-302215-sqrbj5r4 160 23 Protocol Protocol NNP cord-302215-sqrbj5r4 160 24 : : : cord-302215-sqrbj5r4 160 25 Remdesivir Remdesivir NNP cord-302215-sqrbj5r4 160 26 ( ( -LRB- cord-302215-sqrbj5r4 160 27 RDV RDV NNP cord-302215-sqrbj5r4 160 28 ; ; : cord-302215-sqrbj5r4 160 29 GS-5734 GS-5734 NNP cord-302215-sqrbj5r4 160 30 ) ) -RRB- cord-302215-sqrbj5r4 160 31 for for IN cord-302215-sqrbj5r4 160 32 the the DT cord-302215-sqrbj5r4 160 33 Treatment Treatment NNP cord-302215-sqrbj5r4 160 34 of of IN cord-302215-sqrbj5r4 160 35 SARS SARS NNP cord-302215-sqrbj5r4 160 36 - - HYPH cord-302215-sqrbj5r4 160 37 CoV2 CoV2 NNP cord-302215-sqrbj5r4 160 38 ( ( -LRB- cord-302215-sqrbj5r4 160 39 CoV CoV NNP cord-302215-sqrbj5r4 160 40 ) ) -RRB- cord-302215-sqrbj5r4 160 41 infection infection NN cord-302215-sqrbj5r4 160 42 ( ( -LRB- cord-302215-sqrbj5r4 160 43 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 160 44 ) ) -RRB- cord-302215-sqrbj5r4 161 1 Early early RB cord-302215-sqrbj5r4 161 2 Peek Peek NNP cord-302215-sqrbj5r4 161 3 at at IN cord-302215-sqrbj5r4 161 4 Data datum NNS cord-302215-sqrbj5r4 161 5 on on IN cord-302215-sqrbj5r4 161 6 Gilead Gilead NNP cord-302215-sqrbj5r4 161 7 Coronavirus Coronavirus NNP cord-302215-sqrbj5r4 161 8 Drug Drug NNP cord-302215-sqrbj5r4 161 9 Suggests suggest VBZ cord-302215-sqrbj5r4 161 10 Patients patient NNS cord-302215-sqrbj5r4 161 11 are be VBP cord-302215-sqrbj5r4 161 12 Responding respond VBG cord-302215-sqrbj5r4 161 13 to to IN cord-302215-sqrbj5r4 161 14 Treatment Treatment NNP cord-302215-sqrbj5r4 161 15 Gilead Gilead NNP cord-302215-sqrbj5r4 162 1 Announces announce VBZ cord-302215-sqrbj5r4 162 2 Results result NNS cord-302215-sqrbj5r4 162 3 from from IN cord-302215-sqrbj5r4 162 4 Phase Phase NNP cord-302215-sqrbj5r4 162 5 3 3 CD cord-302215-sqrbj5r4 162 6 Trial Trial NNP cord-302215-sqrbj5r4 162 7 of of IN cord-302215-sqrbj5r4 162 8 Investigational Investigational NNP cord-302215-sqrbj5r4 162 9 Antiviral Antiviral NNP cord-302215-sqrbj5r4 162 10 Remdesivir Remdesivir NNP cord-302215-sqrbj5r4 162 11 in in IN cord-302215-sqrbj5r4 162 12 Patients patient NNS cord-302215-sqrbj5r4 162 13 with with IN cord-302215-sqrbj5r4 163 1 Severe severe JJ cord-302215-sqrbj5r4 163 2 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 163 3 Remdesivir Remdesivir NNP cord-302215-sqrbj5r4 163 4 in in IN cord-302215-sqrbj5r4 163 5 adults adult NNS cord-302215-sqrbj5r4 163 6 with with IN cord-302215-sqrbj5r4 163 7 severe severe JJ cord-302215-sqrbj5r4 163 8 COVID-19 covid-19 NN cord-302215-sqrbj5r4 163 9 : : : cord-302215-sqrbj5r4 163 10 A a DT cord-302215-sqrbj5r4 163 11 randomised randomised JJ cord-302215-sqrbj5r4 163 12 , , , cord-302215-sqrbj5r4 163 13 double double JJ cord-302215-sqrbj5r4 163 14 - - HYPH cord-302215-sqrbj5r4 163 15 blind blind JJ cord-302215-sqrbj5r4 163 16 , , , cord-302215-sqrbj5r4 163 17 placebo placebo NN cord-302215-sqrbj5r4 163 18 - - HYPH cord-302215-sqrbj5r4 163 19 controlled control VBN cord-302215-sqrbj5r4 163 20 , , , cord-302215-sqrbj5r4 163 21 multicentre multicentre NNP cord-302215-sqrbj5r4 163 22 trial trial NN cord-302215-sqrbj5r4 163 23 Methods method NNS cord-302215-sqrbj5r4 163 24 for for IN cord-302215-sqrbj5r4 163 25 treating treat VBG cord-302215-sqrbj5r4 163 26 filoviridae filoviridae NNP cord-302215-sqrbj5r4 163 27 virus virus NN cord-302215-sqrbj5r4 163 28 infections infection NNS cord-302215-sqrbj5r4 163 29 Scaling scale VBG cord-302215-sqrbj5r4 163 30 up up RP cord-302215-sqrbj5r4 163 31 Remdesivir Remdesivir NNP cord-302215-sqrbj5r4 163 32 Amid amid IN cord-302215-sqrbj5r4 163 33 the the DT cord-302215-sqrbj5r4 163 34 Coronavirus Coronavirus NNP cord-302215-sqrbj5r4 163 35 Crisis Crisis NNP cord-302215-sqrbj5r4 163 36 Working Working NNP cord-302215-sqrbj5r4 163 37 to to IN cord-302215-sqrbj5r4 163 38 Supply Supply NNP cord-302215-sqrbj5r4 163 39 Remdesivir Remdesivir NNP cord-302215-sqrbj5r4 163 40 for for IN cord-302215-sqrbj5r4 163 41 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 163 42 A a DT cord-302215-sqrbj5r4 163 43 sporadic sporadic JJ cord-302215-sqrbj5r4 163 44 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 163 45 pneumonia pneumonia NN cord-302215-sqrbj5r4 163 46 treated treat VBN cord-302215-sqrbj5r4 163 47 with with IN cord-302215-sqrbj5r4 163 48 extracorporeal extracorporeal JJ cord-302215-sqrbj5r4 163 49 membrane membrane NN cord-302215-sqrbj5r4 163 50 oxygenation oxygenation NN cord-302215-sqrbj5r4 163 51 in in IN cord-302215-sqrbj5r4 163 52 Tokyo Tokyo NNP cord-302215-sqrbj5r4 163 53 , , , cord-302215-sqrbj5r4 163 54 Japan Japan NNP cord-302215-sqrbj5r4 163 55 . . . cord-302215-sqrbj5r4 164 1 A a DT cord-302215-sqrbj5r4 164 2 case case NN cord-302215-sqrbj5r4 164 3 report report NN cord-302215-sqrbj5r4 164 4 Coronavirus Coronavirus NNP cord-302215-sqrbj5r4 164 5 disease disease NN cord-302215-sqrbj5r4 164 6 2019 2019 CD cord-302215-sqrbj5r4 165 1 ( ( -LRB- cord-302215-sqrbj5r4 165 2 Covid-19 Covid-19 NNP cord-302215-sqrbj5r4 165 3 ) ) -RRB- cord-302215-sqrbj5r4 165 4 pneumonia pneumonia NN cord-302215-sqrbj5r4 165 5 in in IN cord-302215-sqrbj5r4 165 6 hemodialysis hemodialysis NN cord-302215-sqrbj5r4 165 7 patients patient NNS cord-302215-sqrbj5r4 165 8 Clinical clinical JJ cord-302215-sqrbj5r4 165 9 features feature NNS cord-302215-sqrbj5r4 165 10 of of IN cord-302215-sqrbj5r4 165 11 COVID-19 covid-19 CD cord-302215-sqrbj5r4 165 12 in in IN cord-302215-sqrbj5r4 165 13 elderly elderly JJ cord-302215-sqrbj5r4 165 14 patients patient NNS cord-302215-sqrbj5r4 165 15 : : : cord-302215-sqrbj5r4 166 1 A a DT cord-302215-sqrbj5r4 166 2 comparison comparison NN cord-302215-sqrbj5r4 166 3 with with IN cord-302215-sqrbj5r4 166 4 young young JJ cord-302215-sqrbj5r4 166 5 and and CC cord-302215-sqrbj5r4 166 6 middle middle JJ cord-302215-sqrbj5r4 166 7 - - HYPH cord-302215-sqrbj5r4 166 8 aged aged JJ cord-302215-sqrbj5r4 166 9 patients patient NNS cord-302215-sqrbj5r4 166 10 Lopinavir Lopinavir NNP cord-302215-sqrbj5r4 166 11 / / SYM cord-302215-sqrbj5r4 166 12 ritonavir ritonavir NNP cord-302215-sqrbj5r4 166 13 did do VBD cord-302215-sqrbj5r4 166 14 not not RB cord-302215-sqrbj5r4 166 15 shorten shorten VB cord-302215-sqrbj5r4 166 16 the the DT cord-302215-sqrbj5r4 166 17 duration duration NN cord-302215-sqrbj5r4 166 18 of of IN cord-302215-sqrbj5r4 166 19 SARS SARS NNP cord-302215-sqrbj5r4 166 20 CoV-2 CoV-2 NNP cord-302215-sqrbj5r4 166 21 shedding shed VBG cord-302215-sqrbj5r4 166 22 in in IN cord-302215-sqrbj5r4 166 23 patients patient NNS cord-302215-sqrbj5r4 166 24 with with IN cord-302215-sqrbj5r4 166 25 mild mild JJ cord-302215-sqrbj5r4 166 26 pneumonia pneumonia NN cord-302215-sqrbj5r4 166 27 in in IN cord-302215-sqrbj5r4 166 28 Taiwan Taiwan NNP cord-302215-sqrbj5r4 166 29 Lopinavir Lopinavir NNP cord-302215-sqrbj5r4 166 30 - - HYPH cord-302215-sqrbj5r4 166 31 ritonavir ritonavir NNP cord-302215-sqrbj5r4 166 32 alone alone RB cord-302215-sqrbj5r4 166 33 or or CC cord-302215-sqrbj5r4 166 34 combined combine VBN cord-302215-sqrbj5r4 166 35 with with IN cord-302215-sqrbj5r4 166 36 arbidol arbidol NN cord-302215-sqrbj5r4 166 37 in in IN cord-302215-sqrbj5r4 166 38 the the DT cord-302215-sqrbj5r4 166 39 treatment treatment NN cord-302215-sqrbj5r4 166 40 of of IN cord-302215-sqrbj5r4 166 41 73 73 CD cord-302215-sqrbj5r4 166 42 hospitalized hospitalize VBN cord-302215-sqrbj5r4 166 43 patients patient NNS cord-302215-sqrbj5r4 166 44 with with IN cord-302215-sqrbj5r4 166 45 COVID-19 covid-19 CD cord-302215-sqrbj5r4 166 46 : : : cord-302215-sqrbj5r4 166 47 A a DT cord-302215-sqrbj5r4 166 48 pilot pilot NN cord-302215-sqrbj5r4 166 49 retrospective retrospective JJ cord-302215-sqrbj5r4 166 50 study study NN cord-302215-sqrbj5r4 167 1 A a DT cord-302215-sqrbj5r4 167 2 trial trial NN cord-302215-sqrbj5r4 167 3 of of IN cord-302215-sqrbj5r4 167 4 Lopinavir Lopinavir NNP cord-302215-sqrbj5r4 167 5 - - HYPH cord-302215-sqrbj5r4 167 6 Ritonavir Ritonavir NNP cord-302215-sqrbj5r4 167 7 in in IN cord-302215-sqrbj5r4 167 8 adults adult NNS cord-302215-sqrbj5r4 167 9 hospitalized hospitalize VBN cord-302215-sqrbj5r4 167 10 with with IN cord-302215-sqrbj5r4 167 11 severe severe JJ cord-302215-sqrbj5r4 167 12 Covid-19 covid-19 NN cord-302215-sqrbj5r4 167 13 Chloroquine Chloroquine NNP cord-302215-sqrbj5r4 167 14 and and CC cord-302215-sqrbj5r4 167 15 beyond beyond IN cord-302215-sqrbj5r4 167 16 : : : cord-302215-sqrbj5r4 167 17 Exploring explore VBG cord-302215-sqrbj5r4 167 18 anti anti JJ cord-302215-sqrbj5r4 167 19 - - JJ cord-302215-sqrbj5r4 167 20 rheumatic rheumatic JJ cord-302215-sqrbj5r4 167 21 drugs drug NNS cord-302215-sqrbj5r4 167 22 to to TO cord-302215-sqrbj5r4 167 23 reduce reduce VB cord-302215-sqrbj5r4 167 24 immune immune JJ cord-302215-sqrbj5r4 167 25 hyperactivation hyperactivation NN cord-302215-sqrbj5r4 167 26 in in IN cord-302215-sqrbj5r4 167 27 HIV HIV NNP cord-302215-sqrbj5r4 167 28 / / SYM cord-302215-sqrbj5r4 167 29 AIDS AIDS NNP cord-302215-sqrbj5r4 167 30 Clinical clinical JJ cord-302215-sqrbj5r4 167 31 and and CC cord-302215-sqrbj5r4 167 32 microbiological microbiological JJ cord-302215-sqrbj5r4 167 33 effect effect NN cord-302215-sqrbj5r4 167 34 of of IN cord-302215-sqrbj5r4 167 35 a a DT cord-302215-sqrbj5r4 167 36 combination combination NN cord-302215-sqrbj5r4 167 37 of of IN cord-302215-sqrbj5r4 167 38 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 167 39 and and CC cord-302215-sqrbj5r4 167 40 azithromycin azithromycin NNP cord-302215-sqrbj5r4 167 41 in in IN cord-302215-sqrbj5r4 167 42 80 80 CD cord-302215-sqrbj5r4 167 43 COVID-19 covid-19 JJ cord-302215-sqrbj5r4 167 44 patients patient NNS cord-302215-sqrbj5r4 167 45 with with IN cord-302215-sqrbj5r4 167 46 at at RB cord-302215-sqrbj5r4 167 47 least least JJS cord-302215-sqrbj5r4 167 48 a a DT cord-302215-sqrbj5r4 167 49 six six CD cord-302215-sqrbj5r4 167 50 - - HYPH cord-302215-sqrbj5r4 167 51 day day NN cord-302215-sqrbj5r4 167 52 follow follow VB cord-302215-sqrbj5r4 167 53 up up RP cord-302215-sqrbj5r4 167 54 : : : cord-302215-sqrbj5r4 167 55 A a DT cord-302215-sqrbj5r4 167 56 pilot pilot NN cord-302215-sqrbj5r4 167 57 observational observational JJ cord-302215-sqrbj5r4 167 58 study study NN cord-302215-sqrbj5r4 167 59 Hydroxychloroquine Hydroxychloroquine NNP cord-302215-sqrbj5r4 167 60 and and CC cord-302215-sqrbj5r4 167 61 azithromycin azithromycin NNP cord-302215-sqrbj5r4 167 62 as as IN cord-302215-sqrbj5r4 167 63 a a DT cord-302215-sqrbj5r4 167 64 treatment treatment NN cord-302215-sqrbj5r4 167 65 of of IN cord-302215-sqrbj5r4 167 66 COVID-19 covid-19 NN cord-302215-sqrbj5r4 167 67 : : : cord-302215-sqrbj5r4 167 68 Results result NNS cord-302215-sqrbj5r4 167 69 of of IN cord-302215-sqrbj5r4 167 70 an an DT cord-302215-sqrbj5r4 167 71 open open JJ cord-302215-sqrbj5r4 167 72 - - HYPH cord-302215-sqrbj5r4 167 73 label label NN cord-302215-sqrbj5r4 167 74 non non JJ cord-302215-sqrbj5r4 167 75 - - JJ cord-302215-sqrbj5r4 167 76 randomized randomized JJ cord-302215-sqrbj5r4 167 77 clinical clinical JJ cord-302215-sqrbj5r4 167 78 trial trial NN cord-302215-sqrbj5r4 168 1 No no DT cord-302215-sqrbj5r4 168 2 evidence evidence NN cord-302215-sqrbj5r4 168 3 of of IN cord-302215-sqrbj5r4 168 4 rapid rapid JJ cord-302215-sqrbj5r4 168 5 antiviral antiviral JJ cord-302215-sqrbj5r4 168 6 clearance clearance NN cord-302215-sqrbj5r4 168 7 or or CC cord-302215-sqrbj5r4 168 8 clinical clinical JJ cord-302215-sqrbj5r4 168 9 benefit benefit NN cord-302215-sqrbj5r4 168 10 with with IN cord-302215-sqrbj5r4 168 11 the the DT cord-302215-sqrbj5r4 168 12 combination combination NN cord-302215-sqrbj5r4 168 13 of of IN cord-302215-sqrbj5r4 168 14 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 168 15 and and CC cord-302215-sqrbj5r4 168 16 azithromycin azithromycin NNP cord-302215-sqrbj5r4 168 17 in in IN cord-302215-sqrbj5r4 168 18 patients patient NNS cord-302215-sqrbj5r4 168 19 with with IN cord-302215-sqrbj5r4 168 20 severe severe JJ cord-302215-sqrbj5r4 168 21 COVID-19 covid-19 JJ cord-302215-sqrbj5r4 168 22 infection infection NN cord-302215-sqrbj5r4 168 23 Outcomes Outcomes NNPS cord-302215-sqrbj5r4 168 24 of of IN cord-302215-sqrbj5r4 168 25 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 168 26 usage usage NN cord-302215-sqrbj5r4 168 27 in in IN cord-302215-sqrbj5r4 168 28 United United NNP cord-302215-sqrbj5r4 168 29 States States NNP cord-302215-sqrbj5r4 168 30 veterans veteran NNS cord-302215-sqrbj5r4 168 31 hospitalized hospitalize VBN cord-302215-sqrbj5r4 168 32 with with IN cord-302215-sqrbj5r4 168 33 Covid-19 Covid-19 NNP cord-302215-sqrbj5r4 168 34 Experience Experience NNP cord-302215-sqrbj5r4 168 35 with with IN cord-302215-sqrbj5r4 168 36 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 168 37 and and CC cord-302215-sqrbj5r4 168 38 azithromycin azithromycin NNP cord-302215-sqrbj5r4 168 39 in in IN cord-302215-sqrbj5r4 168 40 the the DT cord-302215-sqrbj5r4 168 41 COVID-19 covid-19 JJ cord-302215-sqrbj5r4 168 42 pandemic pandemic NN cord-302215-sqrbj5r4 168 43 : : : cord-302215-sqrbj5r4 168 44 Implications implication NNS cord-302215-sqrbj5r4 168 45 for for IN cord-302215-sqrbj5r4 168 46 QT qt NN cord-302215-sqrbj5r4 168 47 interval interval NN cord-302215-sqrbj5r4 168 48 monitoring monitor VBG cord-302215-sqrbj5r4 168 49 Safety Safety NNP cord-302215-sqrbj5r4 168 50 of of IN cord-302215-sqrbj5r4 168 51 hydroxychloroquine hydroxychloroquine NNP cord-302215-sqrbj5r4 168 52 , , , cord-302215-sqrbj5r4 168 53 alone alone JJ cord-302215-sqrbj5r4 168 54 and and CC cord-302215-sqrbj5r4 168 55 in in IN cord-302215-sqrbj5r4 168 56 combination combination NN cord-302215-sqrbj5r4 168 57 with with IN cord-302215-sqrbj5r4 168 58 azithromycin azithromycin NNP cord-302215-sqrbj5r4 168 59 , , , cord-302215-sqrbj5r4 168 60 in in IN cord-302215-sqrbj5r4 168 61 light light NN cord-302215-sqrbj5r4 168 62 of of IN cord-302215-sqrbj5r4 168 63 rapid rapid JJ cord-302215-sqrbj5r4 168 64 widespread widespread JJ cord-302215-sqrbj5r4 168 65 use use NN cord-302215-sqrbj5r4 168 66 for for IN cord-302215-sqrbj5r4 168 67 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 168 68 : : : cord-302215-sqrbj5r4 168 69 A a DT cord-302215-sqrbj5r4 168 70 multinational multinational JJ cord-302215-sqrbj5r4 168 71 , , , cord-302215-sqrbj5r4 168 72 network network NN cord-302215-sqrbj5r4 168 73 cohort cohort NN cord-302215-sqrbj5r4 168 74 and and CC cord-302215-sqrbj5r4 168 75 self self NN cord-302215-sqrbj5r4 168 76 - - HYPH cord-302215-sqrbj5r4 168 77 controlled control VBN cord-302215-sqrbj5r4 168 78 case case NN cord-302215-sqrbj5r4 168 79 series series NN cord-302215-sqrbj5r4 168 80 study study NN cord-302215-sqrbj5r4 168 81 No no DT cord-302215-sqrbj5r4 168 82 evidence evidence NN cord-302215-sqrbj5r4 168 83 of of IN cord-302215-sqrbj5r4 168 84 clinical clinical JJ cord-302215-sqrbj5r4 168 85 efficacy efficacy NN cord-302215-sqrbj5r4 168 86 of of IN cord-302215-sqrbj5r4 168 87 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 168 88 in in IN cord-302215-sqrbj5r4 168 89 patients patient NNS cord-302215-sqrbj5r4 168 90 hospitalised hospitalise VBN cord-302215-sqrbj5r4 168 91 for for IN cord-302215-sqrbj5r4 168 92 COVID-19 covid-19 JJ cord-302215-sqrbj5r4 168 93 infection infection NN cord-302215-sqrbj5r4 168 94 and and CC cord-302215-sqrbj5r4 168 95 requiring require VBG cord-302215-sqrbj5r4 168 96 oxygen oxygen NN cord-302215-sqrbj5r4 168 97 : : : cord-302215-sqrbj5r4 168 98 Results result NNS cord-302215-sqrbj5r4 168 99 of of IN cord-302215-sqrbj5r4 168 100 a a DT cord-302215-sqrbj5r4 168 101 study study NN cord-302215-sqrbj5r4 168 102 using use VBG cord-302215-sqrbj5r4 168 103 routinely routinely RB cord-302215-sqrbj5r4 168 104 collected collect VBN cord-302215-sqrbj5r4 168 105 data datum NNS cord-302215-sqrbj5r4 168 106 to to TO cord-302215-sqrbj5r4 168 107 emulate emulate VB cord-302215-sqrbj5r4 168 108 a a DT cord-302215-sqrbj5r4 168 109 target target NN cord-302215-sqrbj5r4 168 110 trial trial NN cord-302215-sqrbj5r4 168 111 Chloroquine Chloroquine NNP cord-302215-sqrbj5r4 168 112 diphosphate diphosphate NN cord-302215-sqrbj5r4 168 113 in in IN cord-302215-sqrbj5r4 168 114 two two CD cord-302215-sqrbj5r4 168 115 different different JJ cord-302215-sqrbj5r4 168 116 dosages dosage NNS cord-302215-sqrbj5r4 168 117 as as IN cord-302215-sqrbj5r4 168 118 adjunctive adjunctive JJ cord-302215-sqrbj5r4 168 119 therapy therapy NN cord-302215-sqrbj5r4 168 120 of of IN cord-302215-sqrbj5r4 168 121 hospitalized hospitalize VBN cord-302215-sqrbj5r4 168 122 patients patient NNS cord-302215-sqrbj5r4 168 123 with with IN cord-302215-sqrbj5r4 168 124 severe severe JJ cord-302215-sqrbj5r4 168 125 respiratory respiratory JJ cord-302215-sqrbj5r4 168 126 syndrome syndrome NN cord-302215-sqrbj5r4 168 127 in in IN cord-302215-sqrbj5r4 168 128 the the DT cord-302215-sqrbj5r4 168 129 context context NN cord-302215-sqrbj5r4 168 130 of of IN cord-302215-sqrbj5r4 168 131 coronavirus coronavirus NN cord-302215-sqrbj5r4 168 132 ( ( -LRB- cord-302215-sqrbj5r4 168 133 SARS SARS NNP cord-302215-sqrbj5r4 168 134 - - HYPH cord-302215-sqrbj5r4 168 135 CoV-2 CoV-2 NNP cord-302215-sqrbj5r4 168 136 ) ) -RRB- cord-302215-sqrbj5r4 168 137 infection infection NN cord-302215-sqrbj5r4 168 138 : : : cord-302215-sqrbj5r4 168 139 Preliminary preliminary JJ cord-302215-sqrbj5r4 168 140 safety safety NN cord-302215-sqrbj5r4 168 141 results result NNS cord-302215-sqrbj5r4 168 142 of of IN cord-302215-sqrbj5r4 168 143 a a DT cord-302215-sqrbj5r4 168 144 randomized randomized JJ cord-302215-sqrbj5r4 168 145 , , , cord-302215-sqrbj5r4 168 146 double double JJ cord-302215-sqrbj5r4 168 147 - - HYPH cord-302215-sqrbj5r4 168 148 blinded blinded JJ cord-302215-sqrbj5r4 168 149 Concentration concentration NN cord-302215-sqrbj5r4 168 150 - - HYPH cord-302215-sqrbj5r4 168 151 dependent dependent JJ cord-302215-sqrbj5r4 168 152 mortality mortality NN cord-302215-sqrbj5r4 168 153 of of IN cord-302215-sqrbj5r4 168 154 chloroquine chloroquine NN cord-302215-sqrbj5r4 168 155 in in IN cord-302215-sqrbj5r4 168 156 overdose overdose NN cord-302215-sqrbj5r4 168 157 Pharmacokinetic pharmacokinetic JJ cord-302215-sqrbj5r4 168 158 bases basis NNS cord-302215-sqrbj5r4 168 159 of of IN cord-302215-sqrbj5r4 168 160 the the DT cord-302215-sqrbj5r4 168 161 hydroxychloroquine hydroxychloroquine NN cord-302215-sqrbj5r4 168 162 response response NN cord-302215-sqrbj5r4 168 163 in in IN cord-302215-sqrbj5r4 168 164 COVID-19 COVID-19 NNP cord-302215-sqrbj5r4 168 165 : : : cord-302215-sqrbj5r4 168 166 Implications implication NNS cord-302215-sqrbj5r4 168 167 for for IN cord-302215-sqrbj5r4 168 168 therapy therapy NN cord-302215-sqrbj5r4 168 169 and and CC cord-302215-sqrbj5r4 168 170 prevention prevention NN cord-302215-sqrbj5r4 168 171 Hydroxychloroquine Hydroxychloroquine NNP cord-302215-sqrbj5r4 168 172 as as IN cord-302215-sqrbj5r4 168 173 an an DT cord-302215-sqrbj5r4 168 174 aerosol aerosol NN cord-302215-sqrbj5r4 168 175 might may MD cord-302215-sqrbj5r4 168 176 markedly markedly RB cord-302215-sqrbj5r4 168 177 reduce reduce VB cord-302215-sqrbj5r4 168 178 and and CC cord-302215-sqrbj5r4 168 179 even even RB cord-302215-sqrbj5r4 168 180 prevent prevent VB cord-302215-sqrbj5r4 168 181 severe severe JJ cord-302215-sqrbj5r4 168 182 clinical clinical JJ cord-302215-sqrbj5r4 168 183 symptoms symptom NNS cord-302215-sqrbj5r4 168 184 after after IN cord-302215-sqrbj5r4 168 185 SARS SARS NNP cord-302215-sqrbj5r4 168 186 - - HYPH cord-302215-sqrbj5r4 168 187 CoV-2 CoV-2 NNP cord-302215-sqrbj5r4 168 188 infection infection NN cord-302215-sqrbj5r4 168 189 This this DT cord-302215-sqrbj5r4 168 190 article article NN cord-302215-sqrbj5r4 168 191 is be VBZ cord-302215-sqrbj5r4 168 192 an an DT cord-302215-sqrbj5r4 168 193 open open JJ cord-302215-sqrbj5r4 168 194 access access NN cord-302215-sqrbj5r4 168 195 article article NN cord-302215-sqrbj5r4 168 196 distributed distribute VBN cord-302215-sqrbj5r4 168 197 under under IN cord-302215-sqrbj5r4 168 198 the the DT cord-302215-sqrbj5r4 168 199 terms term NNS cord-302215-sqrbj5r4 168 200 and and CC cord-302215-sqrbj5r4 168 201 conditions condition NNS cord-302215-sqrbj5r4 168 202 of of IN cord-302215-sqrbj5r4 168 203 the the DT cord-302215-sqrbj5r4 168 204 Creative Creative NNP cord-302215-sqrbj5r4 168 205 Commons Commons NNP cord-302215-sqrbj5r4 168 206 Attribution Attribution NNP cord-302215-sqrbj5r4 168 207 ( ( -LRB- cord-302215-sqrbj5r4 168 208 CC CC NNP cord-302215-sqrbj5r4 168 209 BY by IN cord-302215-sqrbj5r4 168 210 ) ) -RRB- cord-302215-sqrbj5r4 168 211 license license NN cord-302215-sqrbj5r4 168 212 Funding funding NN cord-302215-sqrbj5r4 168 213 : : : cord-302215-sqrbj5r4 169 1 This this DT cord-302215-sqrbj5r4 169 2 research research NN cord-302215-sqrbj5r4 169 3 received receive VBD cord-302215-sqrbj5r4 169 4 no no DT cord-302215-sqrbj5r4 169 5 external external JJ cord-302215-sqrbj5r4 169 6 funding funding NN cord-302215-sqrbj5r4 169 7 . . . cord-302215-sqrbj5r4 170 1 Any any DT cord-302215-sqrbj5r4 170 2 bibliographic bibliographic JJ cord-302215-sqrbj5r4 170 3 omission omission NN cord-302215-sqrbj5r4 170 4 must must MD cord-302215-sqrbj5r4 170 5 not not RB cord-302215-sqrbj5r4 170 6 be be VB cord-302215-sqrbj5r4 170 7 linked link VBN cord-302215-sqrbj5r4 170 8 to to IN cord-302215-sqrbj5r4 170 9 a a DT cord-302215-sqrbj5r4 170 10 conflict conflict NN cord-302215-sqrbj5r4 170 11 of of IN cord-302215-sqrbj5r4 170 12 interest interest NN cord-302215-sqrbj5r4 170 13 but but CC cord-302215-sqrbj5r4 170 14 simply simply RB cord-302215-sqrbj5r4 170 15 reflects reflect VBZ cord-302215-sqrbj5r4 170 16 a a DT cord-302215-sqrbj5r4 170 17 gap gap NN cord-302215-sqrbj5r4 170 18 when when WRB cord-302215-sqrbj5r4 170 19 searching search VBG cord-302215-sqrbj5r4 170 20 the the DT cord-302215-sqrbj5r4 170 21 oversized oversized JJ cord-302215-sqrbj5r4 170 22 sources source NNS cord-302215-sqrbj5r4 170 23 of of IN cord-302215-sqrbj5r4 170 24 information information NN cord-302215-sqrbj5r4 170 25 on on IN cord-302215-sqrbj5r4 170 26 the the DT cord-302215-sqrbj5r4 170 27 subject subject NN cord-302215-sqrbj5r4 170 28 . . .