id author title date pages extension mime words sentences flesch summary cache txt cord-005705-j765ruj1 Dreyfuss, Didier Is it better to consent to an RCT or to care?: Μηδεν αγαν (“nothing in excess”) 2004-12-17 .txt text/plain 7508 375 47 Another contention of the present paper is this [14] : critical care physicians may still believe that RCTs remain the best tool for improving knowledge and care, and in this case they must accept to use the means needed to achieve the end and therefore to insist on mandatory informed consent from the patient or proxy; or they may realize that the game is not worth the candle and they must then turn to other forms of research that are ranked less highly in the pyramid of evidence-based medicine [15] . Before discussing the problem of informed consent to research a critical appraisal of the scientific and ethical validity of RCTs in critical care medicine is in order. ./cache/cord-005705-j765ruj1.txt ./txt/cord-005705-j765ruj1.txt