id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267608-0odu8lus	Chen, Daohong	Innovative highlights of clinical drug trial design	2020-06-03		.txt	text/plain	4164	155	28	Accordingly taking the advantage of interim analysis based on novel biomarker approach for detecting the pathogenesis-specific molecular alteration(s), an adaptive clinical study can select the drug-sensitive sub-population from patients with initially targeted disease or an alternative indication, to continue the investigation for an optimized therapeutic efficacy [7] . While human bioequivalence study is increasingly contributing to evaluation of emerging formulation and bio-similar agents besides chemical generics [4] , several adaptive trial designs have been capable of translating the scientific breakthroughs into novel therapeutic benefits with shorter processing time and lower financial costs, to address the unmet clinical needs [3, 19] . Of note, to preserve the strength of clear defining efficacy and safety of tested drugs, the innovative designs of clinical study are substantially overlapped with classic trial protocols of three phases which still serve as the mainstream approach of clinical investigation [3, 7] .	./cache/cord-267608-0odu8lus.txt	./txt/cord-267608-0odu8lus.txt