id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326331-g4o3forj	Rai, Ansaar T	Neuroendovascular clinical trials disruptions due to COVID-19 potential future challenges and opportunities	2020-06-30		.txt	text/plain	3459	195	43	METHODS: A survey-based study focused on randomized controlled trials (RCTs) and single-arm studies for acute ischemic stroke and cerebral aneurysms was developed by a group of senior neurointerventionalists and sent to sites identified through the clinical trials website (https://clinicaltrials.gov/), study sponsors, and physician investigators. The Food and Drug Administration (FDA) published its guidance on the 'Conduct Of Clinical Trials Of Medical Products During COVID19 Pandemic' for the industry, investigators, and institutional review boards in March 2020 and updated these on April 2, 2020 (https://www. These were identified by the writing group and fell into four categories: general disruption caused by trial suspensions and missed opportunities of enrollment, compromised trial quality due to inability of timely clinical and imaging follow-up, inability to enroll neurologically debilitated patients because legally authorized representatives were not at hand for face to face consent and dated remote consent procedures did not apply and, finally, personal effect of compensation or working conditions on study staff.	./cache/cord-326331-g4o3forj.txt	./txt/cord-326331-g4o3forj.txt