id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345762-khvcoqti	Scott, Ian A.	COVID‐19 pandemic and the tension between the need to act and the need to know	2020-08-06		.txt	text/plain	3438	142	39	The false promise of rushed science A pandemic as serious as COVID-19 will compel some clinicians and patients to try unproven therapies based on theory, in vitro data, animal models, clinical anecdotes, observational studies and uncontrolled trials that may later be shown to be misleading. Hopefully, the same problems will not occur with remdesivir, whichdespite limited and conflicting evidence of clinical improvement from only two placebo-controlled RCT 19, 20 and one non-controlled cohort study 5has now become a 'standard of care' in the United States for COVID-19 patients with severe pneumonia. Separating out these effects, and determining which drugs to use and when (early in the disease course or only at deterioration), will likely require large-scale trials with multiple treatment arms that are sufficiently powered to enable analyses of primary and, where indicated, secondary outcomes across different patient subgroups.	./cache/cord-345762-khvcoqti.txt	./txt/cord-345762-khvcoqti.txt