id	sid	tid	token	lemma	pos
cord-316626-258rbcwb	1	1	key	key	NN
cord-316626-258rbcwb	1	2	:	:	:
cord-316626-258rbcwb	2	1	cord-316626	cord-316626	NNS
cord-316626-258rbcwb	2	2	-	-	HYPH
cord-316626-258rbcwb	2	3	258rbcwb	258rbcwb	CD
cord-316626-258rbcwb	2	4	authors	author	NNS
cord-316626-258rbcwb	2	5	:	:	:
cord-316626-258rbcwb	2	6	Serpa	Serpa	NNP
cord-316626-258rbcwb	2	7	Neto	Neto	NNP
cord-316626-258rbcwb	2	8	,	,	,
cord-316626-258rbcwb	2	9	Ary	Ary	NNP
cord-316626-258rbcwb	2	10	;	;	:
cord-316626-258rbcwb	2	11	Hodgson	Hodgson	NNP
cord-316626-258rbcwb	2	12	,	,	,
cord-316626-258rbcwb	2	13	Carol	Carol	NNP
cord-316626-258rbcwb	2	14	title	title	NN
cord-316626-258rbcwb	2	15	:	:	:
cord-316626-258rbcwb	2	16	Will	Will	MD
cord-316626-258rbcwb	2	17	Evidence	evidence	NN
cord-316626-258rbcwb	2	18	-	-	HYPH
cord-316626-258rbcwb	2	19	based	base	VBN
cord-316626-258rbcwb	2	20	Medicine	Medicine	NNP
cord-316626-258rbcwb	2	21	Survive	survive	VBP
cord-316626-258rbcwb	2	22	the	the	DT
cord-316626-258rbcwb	2	23	COVID-19	COVID-19	NNP
cord-316626-258rbcwb	2	24	Pandemic	Pandemic	NNP
cord-316626-258rbcwb	2	25	?	?	.
cord-316626-258rbcwb	2	26	date	date	NN
cord-316626-258rbcwb	2	27	:	:	:
cord-316626-258rbcwb	2	28	2020	2020	CD
cord-316626-258rbcwb	2	29	-	-	HYPH
cord-316626-258rbcwb	2	30	09	09	CD
cord-316626-258rbcwb	2	31	-	-	SYM
cord-316626-258rbcwb	2	32	17	17	CD
cord-316626-258rbcwb	2	33	journal	journal	NN
cord-316626-258rbcwb	2	34	:	:	:
cord-316626-258rbcwb	2	35	Ann	Ann	NNP
cord-316626-258rbcwb	2	36	Am	Am	NNP
cord-316626-258rbcwb	2	37	Thorac	Thorac	NNP
cord-316626-258rbcwb	2	38	Soc	Soc	NNP
cord-316626-258rbcwb	2	39	DOI	DOI	NNP
cord-316626-258rbcwb	2	40	:	:	:
cord-316626-258rbcwb	2	41	10.1513	10.1513	CD
cord-316626-258rbcwb	2	42	/	/	SYM
cord-316626-258rbcwb	2	43	annalsats.202006	annalsats.202006	NNP
cord-316626-258rbcwb	2	44	-	-	HYPH
cord-316626-258rbcwb	2	45	587ed	587ed	NN
cord-316626-258rbcwb	2	46	sha	sha	NN
cord-316626-258rbcwb	2	47	:	:	:
cord-316626-258rbcwb	2	48	a035066298674cb37cc294a2f37b883ebf5f852c	a035066298674cb37cc294a2f37b883ebf5f852c	NNP
cord-316626-258rbcwb	2	49	doc_id	doc_id	CD
cord-316626-258rbcwb	2	50	:	:	:
cord-316626-258rbcwb	3	1	316626	316626	CD
cord-316626-258rbcwb	3	2	cord_uid	cord_uid	NN
cord-316626-258rbcwb	3	3	:	:	:
cord-316626-258rbcwb	4	1	258rbcwb	258rbcwb	NNP
cord-316626-258rbcwb	4	2	nan	nan	NNP
cord-316626-258rbcwb	5	1	While	while	IN
cord-316626-258rbcwb	5	2	mankind	mankind	NN
cord-316626-258rbcwb	5	3	is	be	VBZ
cord-316626-258rbcwb	5	4	facing	face	VBG
cord-316626-258rbcwb	5	5	the	the	DT
cord-316626-258rbcwb	5	6	worst	bad	JJS
cord-316626-258rbcwb	5	7	global	global	JJ
cord-316626-258rbcwb	5	8	healthcare	healthcare	NN
cord-316626-258rbcwb	5	9	crisis	crisis	NN
cord-316626-258rbcwb	5	10	of	of	IN
cord-316626-258rbcwb	5	11	this	this	DT
cord-316626-258rbcwb	5	12	century	century	NN
cord-316626-258rbcwb	5	13	,	,	,
cord-316626-258rbcwb	5	14	our	-PRON-	PRP$
cord-316626-258rbcwb	5	15	use	use	NN
cord-316626-258rbcwb	5	16	of	of	IN
cord-316626-258rbcwb	5	17	evidence	evidence	NN
cord-316626-258rbcwb	5	18	-	-	HYPH
cord-316626-258rbcwb	5	19	based	base	VBN
cord-316626-258rbcwb	5	20	medicine	medicine	NN
cord-316626-258rbcwb	5	21	has	have	VBZ
cord-316626-258rbcwb	5	22	suffered	suffer	VBN
cord-316626-258rbcwb	5	23	major	major	JJ
cord-316626-258rbcwb	5	24	setbacks	setback	NNS
cord-316626-258rbcwb	5	25	.	.	.
cord-316626-258rbcwb	6	1	As	as	IN
cord-316626-258rbcwb	6	2	recently	recently	RB
cord-316626-258rbcwb	6	3	discussed	discuss	VBN
cord-316626-258rbcwb	6	4	(	(	-LRB-
cord-316626-258rbcwb	6	5	1	1	CD
cord-316626-258rbcwb	6	6	)	)	-RRB-
cord-316626-258rbcwb	6	7	,	,	,
cord-316626-258rbcwb	6	8	social	social	JJ
cord-316626-258rbcwb	6	9	network	network	NN
cord-316626-258rbcwb	6	10	,	,	,
cord-316626-258rbcwb	6	11	television	television	NN
cord-316626-258rbcwb	6	12	shows	show	NNS
cord-316626-258rbcwb	6	13	,	,	,
cord-316626-258rbcwb	6	14	and	and	CC
cord-316626-258rbcwb	6	15	other	other	JJ
cord-316626-258rbcwb	6	16	media	medium	NNS
cord-316626-258rbcwb	6	17	platforms	platform	NNS
cord-316626-258rbcwb	6	18	have	have	VBP
cord-316626-258rbcwb	6	19	been	be	VBN
cord-316626-258rbcwb	6	20	flooded	flood	VBN
cord-316626-258rbcwb	6	21	by	by	IN
cord-316626-258rbcwb	6	22	"	"	``
cord-316626-258rbcwb	6	23	experts	expert	NNS
cord-316626-258rbcwb	6	24	,	,	,
cord-316626-258rbcwb	6	25	"	"	''
cord-316626-258rbcwb	6	26	who	who	WP
cord-316626-258rbcwb	6	27	have	have	VBP
cord-316626-258rbcwb	6	28	voiced	voice	VBN
cord-316626-258rbcwb	6	29	strong	strong	JJ
cord-316626-258rbcwb	6	30	opinions	opinion	NNS
cord-316626-258rbcwb	6	31	on	on	IN
cord-316626-258rbcwb	6	32	the	the	DT
cord-316626-258rbcwb	6	33	treatment	treatment	NN
cord-316626-258rbcwb	6	34	of	of	IN
cord-316626-258rbcwb	6	35	patients	patient	NNS
cord-316626-258rbcwb	6	36	with	with	IN
cord-316626-258rbcwb	6	37	coronavirus	coronavirus	NN
cord-316626-258rbcwb	6	38	disease	disease	NN
cord-316626-258rbcwb	6	39	.	.	.
cord-316626-258rbcwb	7	1	In	in	IN
cord-316626-258rbcwb	7	2	this	this	DT
cord-316626-258rbcwb	7	3	setting	setting	NN
cord-316626-258rbcwb	7	4	,	,	,
cord-316626-258rbcwb	7	5	hydroxychloroquine	hydroxychloroquine	NNP
cord-316626-258rbcwb	7	6	has	have	VBZ
cord-316626-258rbcwb	7	7	been	be	VBN
cord-316626-258rbcwb	7	8	portrayed	portray	VBN
cord-316626-258rbcwb	7	9	as	as	IN
cord-316626-258rbcwb	7	10	a	a	DT
cord-316626-258rbcwb	7	11	potential	potential	JJ
cord-316626-258rbcwb	7	12	lifesaving	lifesaving	JJ
cord-316626-258rbcwb	7	13	drug	drug	NN
cord-316626-258rbcwb	7	14	in	in	IN
cord-316626-258rbcwb	7	15	the	the	DT
cord-316626-258rbcwb	7	16	current	current	JJ
cord-316626-258rbcwb	7	17	pandemic	pandemic	NN
cord-316626-258rbcwb	7	18	,	,	,
cord-316626-258rbcwb	7	19	mainly	mainly	RB
cord-316626-258rbcwb	7	20	based	base	VBN
cord-316626-258rbcwb	7	21	on	on	IN
cord-316626-258rbcwb	7	22	opinion	opinion	NN
cord-316626-258rbcwb	7	23	or	or	CC
cord-316626-258rbcwb	7	24	results	result	NNS
cord-316626-258rbcwb	7	25	of	of	IN
cord-316626-258rbcwb	7	26	small	small	JJ
cord-316626-258rbcwb	7	27	clinical	clinical	JJ
cord-316626-258rbcwb	7	28	studies	study	NNS
cord-316626-258rbcwb	7	29	and	and	CC
cord-316626-258rbcwb	7	30	uncontrolled	uncontrolled	JJ
cord-316626-258rbcwb	7	31	experiments	experiment	NNS
cord-316626-258rbcwb	7	32	(	(	-LRB-
cord-316626-258rbcwb	7	33	2	2	CD
cord-316626-258rbcwb	7	34	,	,	,
cord-316626-258rbcwb	7	35	3	3	CD
cord-316626-258rbcwb	7	36	)	)	-RRB-
cord-316626-258rbcwb	7	37	.	.	.
cord-316626-258rbcwb	8	1	One	one	CD
cord-316626-258rbcwb	8	2	common	common	JJ
cord-316626-258rbcwb	8	3	argument	argument	NN
cord-316626-258rbcwb	8	4	for	for	IN
cord-316626-258rbcwb	8	5	the	the	DT
cord-316626-258rbcwb	8	6	use	use	NN
cord-316626-258rbcwb	8	7	of	of	IN
cord-316626-258rbcwb	8	8	an	an	DT
cord-316626-258rbcwb	8	9	untested	untested	JJ
cord-316626-258rbcwb	8	10	intervention	intervention	NN
cord-316626-258rbcwb	8	11	during	during	IN
cord-316626-258rbcwb	8	12	a	a	DT
cord-316626-258rbcwb	8	13	pandemic	pandemic	NN
cord-316626-258rbcwb	8	14	is	be	VBZ
cord-316626-258rbcwb	8	15	that	that	IN
cord-316626-258rbcwb	8	16	"	"	``
cord-316626-258rbcwb	8	17	we	-PRON-	PRP
cord-316626-258rbcwb	8	18	must	must	MD
cord-316626-258rbcwb	8	19	do	do	VB
cord-316626-258rbcwb	8	20	something	something	NN
cord-316626-258rbcwb	8	21	.	.	.
cord-316626-258rbcwb	9	1	"	"	``
cord-316626-258rbcwb	9	2	This	this	DT
cord-316626-258rbcwb	9	3	may	may	MD
cord-316626-258rbcwb	9	4	be	be	VB
cord-316626-258rbcwb	9	5	dangerous	dangerous	JJ
cord-316626-258rbcwb	9	6	and	and	CC
cord-316626-258rbcwb	9	7	abandons	abandon	VBZ
cord-316626-258rbcwb	9	8	the	the	DT
cord-316626-258rbcwb	9	9	principles	principle	NNS
cord-316626-258rbcwb	9	10	of	of	IN
cord-316626-258rbcwb	9	11	evidence	evidence	NN
cord-316626-258rbcwb	9	12	-	-	HYPH
cord-316626-258rbcwb	9	13	based	base	VBN
cord-316626-258rbcwb	9	14	medicine	medicine	NN
cord-316626-258rbcwb	9	15	.	.	.
cord-316626-258rbcwb	10	1	Indeed	indeed	RB
cord-316626-258rbcwb	10	2	,	,	,
cord-316626-258rbcwb	10	3	physicians	physician	NNS
cord-316626-258rbcwb	10	4	using	use	VBG
cord-316626-258rbcwb	10	5	an	an	DT
cord-316626-258rbcwb	10	6	untested	untested	JJ
cord-316626-258rbcwb	10	7	intervention	intervention	NN
cord-316626-258rbcwb	10	8	at	at	IN
cord-316626-258rbcwb	10	9	the	the	DT
cord-316626-258rbcwb	10	10	bedside	bedside	NN
cord-316626-258rbcwb	10	11	may	may	MD
cord-316626-258rbcwb	10	12	suffer	suffer	VB
cord-316626-258rbcwb	10	13	from	from	IN
cord-316626-258rbcwb	10	14	attribution	attribution	NN
cord-316626-258rbcwb	10	15	bias	bias	NN
cord-316626-258rbcwb	10	16	,	,	,
cord-316626-258rbcwb	10	17	which	which	WDT
cord-316626-258rbcwb	10	18	is	be	VBZ
cord-316626-258rbcwb	10	19	a	a	DT
cord-316626-258rbcwb	10	20	selective	selective	JJ
cord-316626-258rbcwb	10	21	observation	observation	NN
cord-316626-258rbcwb	10	22	of	of	IN
cord-316626-258rbcwb	10	23	favorable	favorable	JJ
cord-316626-258rbcwb	10	24	effects	effect	NNS
cord-316626-258rbcwb	10	25	attributed	attribute	VBN
cord-316626-258rbcwb	10	26	to	to	IN
cord-316626-258rbcwb	10	27	the	the	DT
cord-316626-258rbcwb	10	28	intervention	intervention	NN
cord-316626-258rbcwb	10	29	that	that	WDT
cord-316626-258rbcwb	10	30	lead	lead	VBP
cord-316626-258rbcwb	10	31	to	to	IN
cord-316626-258rbcwb	10	32	undue	undue	JJ
cord-316626-258rbcwb	10	33	confidence	confidence	NN
cord-316626-258rbcwb	10	34	in	in	IN
cord-316626-258rbcwb	10	35	its	-PRON-	PRP$
cord-316626-258rbcwb	10	36	effectiveness	effectiveness	NN
cord-316626-258rbcwb	10	37	.	.	.
cord-316626-258rbcwb	11	1	The	the	DT
cord-316626-258rbcwb	11	2	other	other	JJ
cord-316626-258rbcwb	11	3	available	available	JJ
cord-316626-258rbcwb	11	4	possibilities	possibility	NNS
cord-316626-258rbcwb	11	5	,	,	,
cord-316626-258rbcwb	11	6	such	such	JJ
cord-316626-258rbcwb	11	7	as	as	IN
cord-316626-258rbcwb	11	8	harm	harm	NN
cord-316626-258rbcwb	11	9	resulting	result	VBG
cord-316626-258rbcwb	11	10	from	from	IN
cord-316626-258rbcwb	11	11	the	the	DT
cord-316626-258rbcwb	11	12	direct	direct	JJ
cord-316626-258rbcwb	11	13	use	use	NN
cord-316626-258rbcwb	11	14	of	of	IN
cord-316626-258rbcwb	11	15	the	the	DT
cord-316626-258rbcwb	11	16	intervention	intervention	NN
cord-316626-258rbcwb	11	17	or	or	CC
cord-316626-258rbcwb	11	18	a	a	DT
cord-316626-258rbcwb	11	19	good	good	JJ
cord-316626-258rbcwb	11	20	recovery	recovery	NN
cord-316626-258rbcwb	11	21	independent	independent	JJ
cord-316626-258rbcwb	11	22	from	from	IN
cord-316626-258rbcwb	11	23	it	-PRON-	PRP
cord-316626-258rbcwb	11	24	,	,	,
cord-316626-258rbcwb	11	25	can	can	MD
cord-316626-258rbcwb	11	26	only	only	RB
cord-316626-258rbcwb	11	27	be	be	VB
cord-316626-258rbcwb	11	28	drawn	draw	VBN
cord-316626-258rbcwb	11	29	with	with	IN
cord-316626-258rbcwb	11	30	well	well	RB
cord-316626-258rbcwb	11	31	-	-	HYPH
cord-316626-258rbcwb	11	32	conducted	conduct	VBN
cord-316626-258rbcwb	11	33	clinical	clinical	JJ
cord-316626-258rbcwb	11	34	trials	trial	NNS
cord-316626-258rbcwb	11	35	.	.	.
cord-316626-258rbcwb	12	1	At	at	IN
cord-316626-258rbcwb	12	2	the	the	DT
cord-316626-258rbcwb	12	3	time	time	NN
cord-316626-258rbcwb	12	4	of	of	IN
cord-316626-258rbcwb	12	5	writing	write	VBG
cord-316626-258rbcwb	12	6	this	this	DT
cord-316626-258rbcwb	12	7	editorial	editorial	NN
cord-316626-258rbcwb	12	8	,	,	,
cord-316626-258rbcwb	12	9	the	the	DT
cord-316626-258rbcwb	12	10	use	use	NN
cord-316626-258rbcwb	12	11	of	of	IN
cord-316626-258rbcwb	12	12	hydroxychloroquine	hydroxychloroquine	NN
cord-316626-258rbcwb	12	13	for	for	IN
cord-316626-258rbcwb	12	14	COVID-19	COVID-19	NNP
cord-316626-258rbcwb	12	15	is	be	VBZ
cord-316626-258rbcwb	12	16	a	a	DT
cord-316626-258rbcwb	12	17	clear	clear	JJ
cord-316626-258rbcwb	12	18	example	example	NN
cord-316626-258rbcwb	12	19	of	of	IN
cord-316626-258rbcwb	12	20	practice	practice	NN
cord-316626-258rbcwb	12	21	changing	change	VBG
cord-316626-258rbcwb	12	22	despite	despite	IN
cord-316626-258rbcwb	12	23	limited	limited	JJ
cord-316626-258rbcwb	12	24	evidence	evidence	NN
cord-316626-258rbcwb	12	25	to	to	TO
cord-316626-258rbcwb	12	26	support	support	VB
cord-316626-258rbcwb	12	27	its	-PRON-	PRP$
cord-316626-258rbcwb	12	28	use	use	NN
cord-316626-258rbcwb	12	29	.	.	.
cord-316626-258rbcwb	13	1	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-316626-258rbcwb	13	2	has	have	VBZ
cord-316626-258rbcwb	13	3	failed	fail	VBN
cord-316626-258rbcwb	13	4	to	to	TO
cord-316626-258rbcwb	13	5	prove	prove	VB
cord-316626-258rbcwb	13	6	beneficial	beneficial	JJ
cord-316626-258rbcwb	13	7	in	in	IN
cord-316626-258rbcwb	13	8	trials	trial	NNS
cord-316626-258rbcwb	13	9	when	when	WRB
cord-316626-258rbcwb	13	10	used	use	VBN
cord-316626-258rbcwb	13	11	as	as	IN
cord-316626-258rbcwb	13	12	a	a	DT
cord-316626-258rbcwb	13	13	potential	potential	JJ
cord-316626-258rbcwb	13	14	treatment	treatment	NN
cord-316626-258rbcwb	13	15	for	for	IN
cord-316626-258rbcwb	13	16	previous	previous	JJ
cord-316626-258rbcwb	13	17	viral	viral	JJ
cord-316626-258rbcwb	13	18	diseases	disease	NNS
cord-316626-258rbcwb	13	19	(	(	-LRB-
cord-316626-258rbcwb	13	20	4	4	CD
cord-316626-258rbcwb	13	21	)	)	-RRB-
cord-316626-258rbcwb	13	22	(	(	-LRB-
cord-316626-258rbcwb	13	23	5	5	LS
cord-316626-258rbcwb	13	24	)	)	-RRB-
cord-316626-258rbcwb	13	25	(	(	-LRB-
cord-316626-258rbcwb	13	26	6	6	CD
cord-316626-258rbcwb	13	27	)	)	-RRB-
cord-316626-258rbcwb	13	28	.	.	.
cord-316626-258rbcwb	14	1	Specifically	specifically	RB
cord-316626-258rbcwb	14	2	,	,	,
cord-316626-258rbcwb	14	3	in	in	IN
cord-316626-258rbcwb	14	4	COVID-19	COVID-19	NNP
cord-316626-258rbcwb	14	5	,	,	,
cord-316626-258rbcwb	14	6	the	the	DT
cord-316626-258rbcwb	14	7	available	available	JJ
cord-316626-258rbcwb	14	8	evidence	evidence	NN
cord-316626-258rbcwb	14	9	points	point	VBZ
cord-316626-258rbcwb	14	10	toward	toward	IN
cord-316626-258rbcwb	14	11	a	a	DT
cord-316626-258rbcwb	14	12	neutral	neutral	JJ
cord-316626-258rbcwb	14	13	effect	effect	NN
cord-316626-258rbcwb	14	14	of	of	IN
cord-316626-258rbcwb	14	15	the	the	DT
cord-316626-258rbcwb	14	16	drug	drug	NN
cord-316626-258rbcwb	14	17	(	(	-LRB-
cord-316626-258rbcwb	14	18	7	7	CD
cord-316626-258rbcwb	14	19	,	,	,
cord-316626-258rbcwb	14	20	8)	8)	NNP
cord-316626-258rbcwb	14	21	,	,	,
cord-316626-258rbcwb	14	22	with	with	IN
cord-316626-258rbcwb	14	23	some	some	DT
cord-316626-258rbcwb	14	24	studies	study	NNS
cord-316626-258rbcwb	14	25	suggesting	suggest	VBG
cord-316626-258rbcwb	14	26	harm	harm	NN
cord-316626-258rbcwb	14	27	(	(	-LRB-
cord-316626-258rbcwb	14	28	9	9	CD
cord-316626-258rbcwb	14	29	)	)	-RRB-
cord-316626-258rbcwb	14	30	.	.	.
cord-316626-258rbcwb	15	1	Nevertheless	nevertheless	RB
cord-316626-258rbcwb	15	2	,	,	,
cord-316626-258rbcwb	15	3	to	to	IN
cord-316626-258rbcwb	15	4	date	date	NN
cord-316626-258rbcwb	15	5	,	,	,
cord-316626-258rbcwb	15	6	there	there	EX
cord-316626-258rbcwb	15	7	are	be	VBP
cord-316626-258rbcwb	15	8	no	no	DT
cord-316626-258rbcwb	15	9	well	well	RB
cord-316626-258rbcwb	15	10	-	-	HYPH
cord-316626-258rbcwb	15	11	powered	power	VBN
cord-316626-258rbcwb	15	12	randomized	randomized	JJ
cord-316626-258rbcwb	15	13	clinical	clinical	JJ
cord-316626-258rbcwb	15	14	trials	trial	NNS
cord-316626-258rbcwb	15	15	testing	test	VBG
cord-316626-258rbcwb	15	16	hydroxychloroquine	hydroxychloroquine	NN
cord-316626-258rbcwb	15	17	in	in	IN
cord-316626-258rbcwb	15	18	this	this	DT
cord-316626-258rbcwb	15	19	group	group	NN
cord-316626-258rbcwb	15	20	of	of	IN
cord-316626-258rbcwb	15	21	patients	patient	NNS
cord-316626-258rbcwb	15	22	to	to	TO
cord-316626-258rbcwb	15	23	inform	inform	VB
cord-316626-258rbcwb	15	24	safety	safety	NN
cord-316626-258rbcwb	15	25	and	and	CC
cord-316626-258rbcwb	15	26	effectiveness	effectiveness	NN
cord-316626-258rbcwb	15	27	.	.	.
cord-316626-258rbcwb	16	1	In	in	IN
cord-316626-258rbcwb	16	2	the	the	DT
cord-316626-258rbcwb	16	3	face	face	NN
cord-316626-258rbcwb	16	4	of	of	IN
cord-316626-258rbcwb	16	5	the	the	DT
cord-316626-258rbcwb	16	6	COVID-19	COVID-19	NNP
cord-316626-258rbcwb	16	7	pandemic	pandemic	NN
cord-316626-258rbcwb	16	8	,	,	,
cord-316626-258rbcwb	16	9	it	-PRON-	PRP
cord-316626-258rbcwb	16	10	is	be	VBZ
cord-316626-258rbcwb	16	11	understandable	understandable	JJ
cord-316626-258rbcwb	16	12	that	that	IN
cord-316626-258rbcwb	16	13	physicians	physician	NNS
cord-316626-258rbcwb	16	14	and	and	CC
cord-316626-258rbcwb	16	15	patients	patient	NNS
cord-316626-258rbcwb	16	16	are	be	VBP
cord-316626-258rbcwb	16	17	scared	scared	JJ
cord-316626-258rbcwb	16	18	,	,	,
cord-316626-258rbcwb	16	19	overwhelmed	overwhelmed	JJ
cord-316626-258rbcwb	16	20	,	,	,
cord-316626-258rbcwb	16	21	and	and	CC
cord-316626-258rbcwb	16	22	want	want	VB
cord-316626-258rbcwb	16	23	quick	quick	JJ
cord-316626-258rbcwb	16	24	answers	answer	NNS
cord-316626-258rbcwb	16	25	.	.	.
cord-316626-258rbcwb	17	1	There	there	EX
cord-316626-258rbcwb	17	2	are	be	VBP
cord-316626-258rbcwb	17	3	concerns	concern	NNS
cord-316626-258rbcwb	17	4	about	about	IN
cord-316626-258rbcwb	17	5	the	the	DT
cord-316626-258rbcwb	17	6	time	time	NN
cord-316626-258rbcwb	17	7	to	to	TO
cord-316626-258rbcwb	17	8	complete	complete	VB
cord-316626-258rbcwb	17	9	randomized	randomized	JJ
cord-316626-258rbcwb	17	10	clinical	clinical	JJ
cord-316626-258rbcwb	17	11	trials	trial	NNS
cord-316626-258rbcwb	17	12	,	,	,
cord-316626-258rbcwb	17	13	and	and	CC
cord-316626-258rbcwb	17	14	this	this	DT
cord-316626-258rbcwb	17	15	is	be	VBZ
cord-316626-258rbcwb	17	16	used	use	VBN
cord-316626-258rbcwb	17	17	as	as	IN
cord-316626-258rbcwb	17	18	a	a	DT
cord-316626-258rbcwb	17	19	justification	justification	NN
cord-316626-258rbcwb	17	20	to	to	TO
cord-316626-258rbcwb	17	21	accept	accept	VB
cord-316626-258rbcwb	17	22	anecdotal	anecdotal	JJ
cord-316626-258rbcwb	17	23	and	and	CC
cord-316626-258rbcwb	17	24	low	low	JJ
cord-316626-258rbcwb	17	25	levels	level	NNS
cord-316626-258rbcwb	17	26	of	of	IN
cord-316626-258rbcwb	17	27	evidence	evidence	NN
cord-316626-258rbcwb	17	28	.	.	.
cord-316626-258rbcwb	18	1	Indeed	indeed	RB
cord-316626-258rbcwb	18	2	,	,	,
cord-316626-258rbcwb	18	3	the	the	DT
cord-316626-258rbcwb	18	4	traditional	traditional	JJ
cord-316626-258rbcwb	18	5	approach	approach	NN
cord-316626-258rbcwb	18	6	to	to	TO
cord-316626-258rbcwb	18	7	validate	validate	VB
cord-316626-258rbcwb	18	8	a	a	DT
cord-316626-258rbcwb	18	9	new	new	JJ
cord-316626-258rbcwb	18	10	treatment	treatment	NN
cord-316626-258rbcwb	18	11	is	be	VBZ
cord-316626-258rbcwb	18	12	to	to	TO
cord-316626-258rbcwb	18	13	complete	complete	VB
cord-316626-258rbcwb	18	14	lengthy	lengthy	JJ
cord-316626-258rbcwb	18	15	phase	phase	NN
cord-316626-258rbcwb	19	1	I	-PRON-	PRP
cord-316626-258rbcwb	19	2	,	,	,
cord-316626-258rbcwb	19	3	II	II	NNP
cord-316626-258rbcwb	19	4	,	,	,
cord-316626-258rbcwb	19	5	and	and	CC
cord-316626-258rbcwb	19	6	III	III	NNP
cord-316626-258rbcwb	19	7	studies	study	NNS
cord-316626-258rbcwb	19	8	.	.	.
cord-316626-258rbcwb	20	1	One	one	CD
cord-316626-258rbcwb	20	2	major	major	JJ
cord-316626-258rbcwb	20	3	challenge	challenge	NN
cord-316626-258rbcwb	20	4	during	during	IN
cord-316626-258rbcwb	20	5	the	the	DT
cord-316626-258rbcwb	20	6	pandemic	pandemic	NN
cord-316626-258rbcwb	20	7	is	be	VBZ
cord-316626-258rbcwb	20	8	to	to	TO
cord-316626-258rbcwb	20	9	design	design	VB
cord-316626-258rbcwb	20	10	clinical	clinical	JJ
cord-316626-258rbcwb	20	11	trials	trial	NNS
cord-316626-258rbcwb	20	12	that	that	WDT
cord-316626-258rbcwb	20	13	can	can	MD
cord-316626-258rbcwb	20	14	mitigate	mitigate	VB
cord-316626-258rbcwb	20	15	these	these	DT
cord-316626-258rbcwb	20	16	concerns	concern	NNS
cord-316626-258rbcwb	20	17	and	and	CC
cord-316626-258rbcwb	20	18	quickly	quickly	RB
cord-316626-258rbcwb	20	19	identify	identify	VB
cord-316626-258rbcwb	20	20	effective	effective	JJ
cord-316626-258rbcwb	20	21	or	or	CC
cord-316626-258rbcwb	20	22	harmful	harmful	JJ
cord-316626-258rbcwb	20	23	interventions	intervention	NNS
cord-316626-258rbcwb	20	24	to	to	TO
cord-316626-258rbcwb	20	25	improve	improve	VB
cord-316626-258rbcwb	20	26	patient	patient	JJ
cord-316626-258rbcwb	20	27	outcomes	outcome	NNS
cord-316626-258rbcwb	20	28	.	.	.
cord-316626-258rbcwb	21	1	Careful	careful	JJ
cord-316626-258rbcwb	21	2	consideration	consideration	NN
cord-316626-258rbcwb	21	3	is	be	VBZ
cord-316626-258rbcwb	21	4	required	require	VBN
cord-316626-258rbcwb	21	5	to	to	TO
cord-316626-258rbcwb	21	6	optimize	optimize	VB
cord-316626-258rbcwb	21	7	trial	trial	NN
cord-316626-258rbcwb	21	8	design	design	NN
cord-316626-258rbcwb	21	9	to	to	TO
cord-316626-258rbcwb	21	10	achieve	achieve	VB
cord-316626-258rbcwb	21	11	this	this	DT
cord-316626-258rbcwb	21	12	,	,	,
cord-316626-258rbcwb	21	13	and	and	CC
cord-316626-258rbcwb	21	14	several	several	JJ
cord-316626-258rbcwb	21	15	novel	novel	JJ
cord-316626-258rbcwb	21	16	trial	trial	NN
cord-316626-258rbcwb	21	17	designs	design	NNS
cord-316626-258rbcwb	21	18	are	be	VBP
cord-316626-258rbcwb	21	19	available	available	JJ
cord-316626-258rbcwb	21	20	and	and	CC
cord-316626-258rbcwb	21	21	could	could	MD
cord-316626-258rbcwb	21	22	be	be	VB
cord-316626-258rbcwb	21	23	considered	consider	VBN
cord-316626-258rbcwb	21	24	.	.	.
cord-316626-258rbcwb	22	1	These	these	DT
cord-316626-258rbcwb	22	2	include	include	VBP
cord-316626-258rbcwb	22	3	adaptive	adaptive	JJ
cord-316626-258rbcwb	22	4	sequential	sequential	JJ
cord-316626-258rbcwb	22	5	designs	design	NNS
cord-316626-258rbcwb	22	6	,	,	,
cord-316626-258rbcwb	22	7	responseadaptive	responseadaptive	JJ
cord-316626-258rbcwb	22	8	randomization	randomization	NN
cord-316626-258rbcwb	22	9	,	,	,
cord-316626-258rbcwb	22	10	historical	historical	JJ
cord-316626-258rbcwb	22	11	and	and	CC
cord-316626-258rbcwb	22	12	dynamic	dynamic	JJ
cord-316626-258rbcwb	22	13	borrowing	borrowing	NN
cord-316626-258rbcwb	22	14	,	,	,
cord-316626-258rbcwb	22	15	multistage	multistage	NN
cord-316626-258rbcwb	22	16	multiarm	multiarm	NNS
cord-316626-258rbcwb	22	17	trials	trial	NNS
cord-316626-258rbcwb	22	18	,	,	,
cord-316626-258rbcwb	22	19	shared	share	VBN
cord-316626-258rbcwb	22	20	controls	control	NNS
cord-316626-258rbcwb	22	21	,	,	,
cord-316626-258rbcwb	22	22	and	and	CC
cord-316626-258rbcwb	22	23	strategies	strategy	NNS
cord-316626-258rbcwb	22	24	that	that	WDT
cord-316626-258rbcwb	22	25	aim	aim	VBP
cord-316626-258rbcwb	22	26	to	to	TO
cord-316626-258rbcwb	22	27	"	"	``
cord-316626-258rbcwb	22	28	pick	pick	VB
cord-316626-258rbcwb	22	29	the	the	DT
cord-316626-258rbcwb	22	30	winner	winner	NN
cord-316626-258rbcwb	22	31	"	"	``
cord-316626-258rbcwb	22	32	to	to	TO
cord-316626-258rbcwb	22	33	identify	identify	VB
cord-316626-258rbcwb	22	34	early	early	RB
cord-316626-258rbcwb	22	35	which	which	WDT
cord-316626-258rbcwb	22	36	treatments	treatment	NNS
cord-316626-258rbcwb	22	37	are	be	VBP
cord-316626-258rbcwb	22	38	effective	effective	JJ
cord-316626-258rbcwb	22	39	.	.	.
cord-316626-258rbcwb	23	1	A	a	DT
cord-316626-258rbcwb	23	2	good	good	JJ
cord-316626-258rbcwb	23	3	example	example	NN
cord-316626-258rbcwb	23	4	of	of	IN
cord-316626-258rbcwb	23	5	trial	trial	NN
cord-316626-258rbcwb	23	6	design	design	NN
cord-316626-258rbcwb	23	7	that	that	WDT
cord-316626-258rbcwb	23	8	allows	allow	VBZ
cord-316626-258rbcwb	23	9	this	this	DT
cord-316626-258rbcwb	23	10	flexibility	flexibility	NN
cord-316626-258rbcwb	23	11	is	be	VBZ
cord-316626-258rbcwb	23	12	Bayesian	bayesian	JJ
cord-316626-258rbcwb	23	13	design	design	NN
cord-316626-258rbcwb	23	14	.	.	.
cord-316626-258rbcwb	24	1	Bayesian	bayesian	JJ
cord-316626-258rbcwb	24	2	trials	trial	NNS
cord-316626-258rbcwb	24	3	allow	allow	VBP
cord-316626-258rbcwb	24	4	evidence	evidence	NN
cord-316626-258rbcwb	24	5	about	about	IN
cord-316626-258rbcwb	24	6	treatment	treatment	NN
cord-316626-258rbcwb	24	7	to	to	TO
cord-316626-258rbcwb	24	8	be	be	VB
cord-316626-258rbcwb	24	9	continually	continually	RB
cord-316626-258rbcwb	24	10	updated	update	VBN
cord-316626-258rbcwb	24	11	with	with	IN
cord-316626-258rbcwb	24	12	new	new	JJ
cord-316626-258rbcwb	24	13	information	information	NN
cord-316626-258rbcwb	24	14	as	as	IN
cord-316626-258rbcwb	24	15	it	-PRON-	PRP
cord-316626-258rbcwb	24	16	becomes	become	VBZ
cord-316626-258rbcwb	24	17	available	available	JJ
cord-316626-258rbcwb	24	18	,	,	,
cord-316626-258rbcwb	24	19	maintaining	maintain	VBG
cord-316626-258rbcwb	24	20	trial	trial	NN
cord-316626-258rbcwb	24	21	integrity	integrity	NN
cord-316626-258rbcwb	24	22	(	(	-LRB-
cord-316626-258rbcwb	24	23	10	10	CD
cord-316626-258rbcwb	24	24	)	)	-RRB-
cord-316626-258rbcwb	24	25	(	(	-LRB-
cord-316626-258rbcwb	24	26	11	11	CD
cord-316626-258rbcwb	24	27	)	)	-RRB-
cord-316626-258rbcwb	24	28	(	(	-LRB-
cord-316626-258rbcwb	24	29	12	12	CD
cord-316626-258rbcwb	24	30	)	)	-RRB-
cord-316626-258rbcwb	24	31	.	.	.
cord-316626-258rbcwb	25	1	Another	another	DT
cord-316626-258rbcwb	25	2	benefit	benefit	NN
cord-316626-258rbcwb	25	3	of	of	IN
cord-316626-258rbcwb	25	4	the	the	DT
cord-316626-258rbcwb	25	5	Bayesian	bayesian	JJ
cord-316626-258rbcwb	25	6	approach	approach	NN
cord-316626-258rbcwb	25	7	is	be	VBZ
cord-316626-258rbcwb	25	8	to	to	TO
cord-316626-258rbcwb	25	9	estimate	estimate	VB
cord-316626-258rbcwb	25	10	the	the	DT
cord-316626-258rbcwb	25	11	probability	probability	NN
cord-316626-258rbcwb	25	12	that	that	IN
cord-316626-258rbcwb	25	13	a	a	DT
cord-316626-258rbcwb	25	14	treatment	treatment	NN
cord-316626-258rbcwb	25	15	is	be	VBZ
cord-316626-258rbcwb	25	16	effective	effective	JJ
cord-316626-258rbcwb	25	17	rather	rather	RB
cord-316626-258rbcwb	25	18	than	than	IN
cord-316626-258rbcwb	25	19	focus	focus	VB
cord-316626-258rbcwb	25	20	on	on	IN
cord-316626-258rbcwb	25	21	whether	whether	IN
cord-316626-258rbcwb	25	22	it	-PRON-	PRP
cord-316626-258rbcwb	25	23	is	be	VBZ
cord-316626-258rbcwb	25	24	effective	effective	JJ
cord-316626-258rbcwb	25	25	or	or	CC
cord-316626-258rbcwb	25	26	not	not	RB
cord-316626-258rbcwb	25	27	according	accord	VBG
cord-316626-258rbcwb	25	28	to	to	IN
cord-316626-258rbcwb	25	29	P	p	NN
cord-316626-258rbcwb	25	30	values	value	NNS
cord-316626-258rbcwb	25	31	.	.	.
cord-316626-258rbcwb	26	1	Frequentist	frequentist	JJ
cord-316626-258rbcwb	26	2	classical	classical	JJ
cord-316626-258rbcwb	26	3	trials	trial	NNS
cord-316626-258rbcwb	26	4	rely	rely	VBP
cord-316626-258rbcwb	26	5	on	on	IN
cord-316626-258rbcwb	26	6	previous	previous	JJ
cord-316626-258rbcwb	26	7	knowledge	knowledge	NN
cord-316626-258rbcwb	26	8	to	to	TO
cord-316626-258rbcwb	26	9	calculate	calculate	VB
cord-316626-258rbcwb	26	10	sample	sample	NN
cord-316626-258rbcwb	26	11	size	size	NN
cord-316626-258rbcwb	26	12	and	and	CC
cord-316626-258rbcwb	26	13	define	define	VB
cord-316626-258rbcwb	26	14	features	feature	NNS
cord-316626-258rbcwb	26	15	of	of	IN
cord-316626-258rbcwb	26	16	the	the	DT
cord-316626-258rbcwb	26	17	study	study	NN
cord-316626-258rbcwb	26	18	according	accord	VBG
cord-316626-258rbcwb	26	19	to	to	IN
cord-316626-258rbcwb	26	20	known	know	VBN
cord-316626-258rbcwb	26	21	assumptions	assumption	NNS
cord-316626-258rbcwb	26	22	about	about	IN
cord-316626-258rbcwb	26	23	the	the	DT
cord-316626-258rbcwb	26	24	treatment	treatment	NN
cord-316626-258rbcwb	26	25	,	,	,
cord-316626-258rbcwb	26	26	something	something	NN
cord-316626-258rbcwb	26	27	not	not	RB
cord-316626-258rbcwb	26	28	widely	widely	RB
cord-316626-258rbcwb	26	29	available	available	JJ
cord-316626-258rbcwb	26	30	during	during	IN
cord-316626-258rbcwb	26	31	a	a	DT
cord-316626-258rbcwb	26	32	pandemic	pandemic	NN
cord-316626-258rbcwb	26	33	.	.	.
cord-316626-258rbcwb	27	1	Also	also	RB
cord-316626-258rbcwb	27	2	,	,	,
cord-316626-258rbcwb	27	3	classical	classical	JJ
cord-316626-258rbcwb	27	4	designs	design	NNS
cord-316626-258rbcwb	27	5	are	be	VBP
cord-316626-258rbcwb	27	6	less	less	RBR
cord-316626-258rbcwb	27	7	flexible	flexible	JJ
cord-316626-258rbcwb	27	8	,	,	,
cord-316626-258rbcwb	27	9	and	and	CC
cord-316626-258rbcwb	27	10	if	if	IN
cord-316626-258rbcwb	27	11	the	the	DT
cord-316626-258rbcwb	27	12	assumptions	assumption	NNS
cord-316626-258rbcwb	27	13	are	be	VBP
cord-316626-258rbcwb	27	14	not	not	RB
cord-316626-258rbcwb	27	15	met	meet	VBN
cord-316626-258rbcwb	27	16	,	,	,
cord-316626-258rbcwb	27	17	the	the	DT
cord-316626-258rbcwb	27	18	study	study	NN
cord-316626-258rbcwb	27	19	will	will	MD
cord-316626-258rbcwb	27	20	end	end	VB
cord-316626-258rbcwb	27	21	without	without	IN
cord-316626-258rbcwb	27	22	providing	provide	VBG
cord-316626-258rbcwb	27	23	useful	useful	JJ
cord-316626-258rbcwb	27	24	evidence	evidence	NN
cord-316626-258rbcwb	27	25	.	.	.
cord-316626-258rbcwb	28	1	In	in	IN
cord-316626-258rbcwb	28	2	a	a	DT
cord-316626-258rbcwb	28	3	pandemic	pandemic	NN
cord-316626-258rbcwb	28	4	with	with	IN
cord-316626-258rbcwb	28	5	more	more	JJR
cord-316626-258rbcwb	28	6	than	than	IN
cord-316626-258rbcwb	28	7	75,000	75,000	CD
cord-316626-258rbcwb	28	8	new	new	JJ
cord-316626-258rbcwb	28	9	cases	case	NNS
cord-316626-258rbcwb	28	10	per	per	IN
cord-316626-258rbcwb	28	11	day	day	NN
cord-316626-258rbcwb	28	12	,	,	,
cord-316626-258rbcwb	28	13	the	the	DT
cord-316626-258rbcwb	28	14	use	use	NN
cord-316626-258rbcwb	28	15	of	of	IN
cord-316626-258rbcwb	28	16	a	a	DT
cord-316626-258rbcwb	28	17	Bayesian	bayesian	JJ
cord-316626-258rbcwb	28	18	adaptive	adaptive	JJ
cord-316626-258rbcwb	28	19	trial	trial	NN
cord-316626-258rbcwb	28	20	design	design	NN
cord-316626-258rbcwb	28	21	can	can	MD
cord-316626-258rbcwb	28	22	quickly	quickly	RB
cord-316626-258rbcwb	28	23	incorporate	incorporate	VB
cord-316626-258rbcwb	28	24	existing	exist	VBG
cord-316626-258rbcwb	28	25	evidence	evidence	NN
cord-316626-258rbcwb	28	26	,	,	,
cord-316626-258rbcwb	28	27	drop	drop	VB
cord-316626-258rbcwb	28	28	interventions	intervention	NNS
cord-316626-258rbcwb	28	29	that	that	WDT
cord-316626-258rbcwb	28	30	have	have	VBP
cord-316626-258rbcwb	28	31	a	a	DT
cord-316626-258rbcwb	28	32	higher	high	JJR
cord-316626-258rbcwb	28	33	probability	probability	NN
cord-316626-258rbcwb	28	34	of	of	IN
cord-316626-258rbcwb	28	35	futility	futility	NN
cord-316626-258rbcwb	28	36	,	,	,
cord-316626-258rbcwb	28	37	redirect	redirect	VB
cord-316626-258rbcwb	28	38	patients	patient	NNS
cord-316626-258rbcwb	28	39	to	to	TO
cord-316626-258rbcwb	28	40	be	be	VB
cord-316626-258rbcwb	28	41	randomized	randomize	VBN
cord-316626-258rbcwb	28	42	to	to	IN
cord-316626-258rbcwb	28	43	the	the	DT
cord-316626-258rbcwb	28	44	most	most	RBS
cord-316626-258rbcwb	28	45	promising	promising	JJ
cord-316626-258rbcwb	28	46	ones	one	NNS
cord-316626-258rbcwb	28	47	,	,	,
cord-316626-258rbcwb	28	48	and	and	CC
cord-316626-258rbcwb	28	49	constantly	constantly	RB
cord-316626-258rbcwb	28	50	include	include	VBP
cord-316626-258rbcwb	28	51	new	new	JJ
cord-316626-258rbcwb	28	52	and	and	CC
cord-316626-258rbcwb	28	53	potential	potential	JJ
cord-316626-258rbcwb	28	54	candidate	candidate	NN
cord-316626-258rbcwb	28	55	interventions	intervention	NNS
cord-316626-258rbcwb	28	56	.	.	.
cord-316626-258rbcwb	29	1	In	in	IN
cord-316626-258rbcwb	29	2	this	this	DT
cord-316626-258rbcwb	29	3	issue	issue	NN
cord-316626-258rbcwb	29	4	of	of	IN
cord-316626-258rbcwb	29	5	AnnalsATS	AnnalsATS	NNP
cord-316626-258rbcwb	29	6	,	,	,
cord-316626-258rbcwb	29	7	Casey	Casey	NNP
cord-316626-258rbcwb	29	8	and	and	CC
cord-316626-258rbcwb	29	9	colleagues	colleague	NNS
cord-316626-258rbcwb	29	10	(	(	-LRB-
cord-316626-258rbcwb	29	11	pp	pp	NNP
cord-316626-258rbcwb	29	12	.	.	NNP
cord-316626-258rbcwb	29	13	1144	1144	CD
cord-316626-258rbcwb	29	14	-	-	SYM
cord-316626-258rbcwb	29	15	1153	1153	CD
cord-316626-258rbcwb	29	16	)	)	-RRB-
cord-316626-258rbcwb	29	17	(	(	-LRB-
cord-316626-258rbcwb	29	18	13	13	CD
cord-316626-258rbcwb	29	19	)	)	-RRB-
cord-316626-258rbcwb	29	20	describe	describe	VB
cord-316626-258rbcwb	29	21	the	the	DT
cord-316626-258rbcwb	29	22	study	study	NN
cord-316626-258rbcwb	29	23	protocol	protocol	NN
cord-316626-258rbcwb	29	24	of	of	IN
cord-316626-258rbcwb	29	25	a	a	DT
cord-316626-258rbcwb	29	26	randomized	randomized	JJ
cord-316626-258rbcwb	29	27	,	,	,
cord-316626-258rbcwb	29	28	doubleblind	doubleblind	NN
cord-316626-258rbcwb	29	29	,	,	,
cord-316626-258rbcwb	29	30	placebo	placebo	NN
cord-316626-258rbcwb	29	31	-	-	HYPH
cord-316626-258rbcwb	29	32	controlled	control	VBN
cord-316626-258rbcwb	29	33	clinical	clinical	JJ
cord-316626-258rbcwb	29	34	trial	trial	NN
cord-316626-258rbcwb	29	35	(	(	-LRB-
cord-316626-258rbcwb	29	36	ORCHID	ORCHID	NNP
cord-316626-258rbcwb	29	37	trial	trial	NN
cord-316626-258rbcwb	29	38	)	)	-RRB-
cord-316626-258rbcwb	29	39	assessing	assess	VBG
cord-316626-258rbcwb	29	40	the	the	DT
cord-316626-258rbcwb	29	41	impact	impact	NN
cord-316626-258rbcwb	29	42	of	of	IN
cord-316626-258rbcwb	29	43	hydroxychloroquine	hydroxychloroquine	NN
cord-316626-258rbcwb	29	44	in	in	IN
cord-316626-258rbcwb	29	45	hospitalized	hospitalize	VBN
cord-316626-258rbcwb	29	46	adults	adult	NNS
cord-316626-258rbcwb	29	47	with	with	IN
cord-316626-258rbcwb	29	48	confirmed	confirm	VBN
cord-316626-258rbcwb	29	49	severe	severe	JJ
cord-316626-258rbcwb	29	50	acute	acute	JJ
cord-316626-258rbcwb	29	51	respiratory	respiratory	JJ
cord-316626-258rbcwb	29	52	syndrome	syndrome	NN
cord-316626-258rbcwb	29	53	coronavirus	coronavirus	NN
cord-316626-258rbcwb	29	54	2	2	CD
cord-316626-258rbcwb	29	55	(	(	-LRB-
cord-316626-258rbcwb	29	56	SARS	SARS	NNP
cord-316626-258rbcwb	29	57	-	-	HYPH
cord-316626-258rbcwb	29	58	Cov-2	Cov-2	NNP
cord-316626-258rbcwb	29	59	)	)	-RRB-
cord-316626-258rbcwb	29	60	and	and	CC
cord-316626-258rbcwb	29	61	symptoms	symptom	NNS
cord-316626-258rbcwb	29	62	of	of	IN
cord-316626-258rbcwb	29	63	acute	acute	JJ
cord-316626-258rbcwb	29	64	respiratory	respiratory	JJ
cord-316626-258rbcwb	29	65	infection	infection	NN
cord-316626-258rbcwb	29	66	.	.	.
cord-316626-258rbcwb	30	1	The	the	DT
cord-316626-258rbcwb	30	2	primary	primary	JJ
cord-316626-258rbcwb	30	3	outcome	outcome	NN
cord-316626-258rbcwb	30	4	of	of	IN
cord-316626-258rbcwb	30	5	the	the	DT
cord-316626-258rbcwb	30	6	study	study	NN
cord-316626-258rbcwb	30	7	is	be	VBZ
cord-316626-258rbcwb	30	8	the	the	DT
cord-316626-258rbcwb	30	9	patient	patient	NN
cord-316626-258rbcwb	30	10	's	's	POS
cord-316626-258rbcwb	30	11	clinical	clinical	JJ
cord-316626-258rbcwb	30	12	status	status	NN
cord-316626-258rbcwb	30	13	14	14	CD
cord-316626-258rbcwb	30	14	days	day	NNS
cord-316626-258rbcwb	30	15	after	after	IN
cord-316626-258rbcwb	30	16	randomization	randomization	NN
cord-316626-258rbcwb	30	17	,	,	,
cord-316626-258rbcwb	30	18	assessed	assess	VBN
cord-316626-258rbcwb	30	19	by	by	IN
cord-316626-258rbcwb	30	20	a	a	DT
cord-316626-258rbcwb	30	21	seven	seven	CD
cord-316626-258rbcwb	30	22	-	-	HYPH
cord-316626-258rbcwb	30	23	category	category	NN
cord-316626-258rbcwb	30	24	ordinal	ordinal	JJ
cord-316626-258rbcwb	30	25	outcome	outcome	NN
cord-316626-258rbcwb	30	26	scale	scale	NN
cord-316626-258rbcwb	30	27	.	.	.
cord-316626-258rbcwb	31	1	An	an	DT
cord-316626-258rbcwb	31	2	important	important	JJ
cord-316626-258rbcwb	31	3	feature	feature	NN
cord-316626-258rbcwb	31	4	is	be	VBZ
cord-316626-258rbcwb	31	5	that	that	IN
cord-316626-258rbcwb	31	6	data	datum	NNS
cord-316626-258rbcwb	31	7	can	can	MD
cord-316626-258rbcwb	31	8	be	be	VB
cord-316626-258rbcwb	31	9	collected	collect	VBN
cord-316626-258rbcwb	31	10	from	from	IN
cord-316626-258rbcwb	31	11	the	the	DT
cord-316626-258rbcwb	31	12	electronic	electronic	JJ
cord-316626-258rbcwb	31	13	health	health	NN
cord-316626-258rbcwb	31	14	record	record	NN
cord-316626-258rbcwb	31	15	,	,	,
cord-316626-258rbcwb	31	16	decreasing	decrease	VBG
cord-316626-258rbcwb	31	17	the	the	DT
cord-316626-258rbcwb	31	18	person	person	NN
cord-316626-258rbcwb	31	19	-	-	HYPH
cord-316626-258rbcwb	31	20	to	to	IN
cord-316626-258rbcwb	31	21	-	-	HYPH
cord-316626-258rbcwb	31	22	person	person	NN
cord-316626-258rbcwb	31	23	contact	contact	NN
cord-316626-258rbcwb	31	24	,	,	,
cord-316626-258rbcwb	31	25	conserving	conserve	VBG
cord-316626-258rbcwb	31	26	personal	personal	JJ
cord-316626-258rbcwb	31	27	protective	protective	JJ
cord-316626-258rbcwb	31	28	equipment	equipment	NN
cord-316626-258rbcwb	31	29	,	,	,
cord-316626-258rbcwb	31	30	and	and	CC
cord-316626-258rbcwb	31	31	reducing	reduce	VBG
cord-316626-258rbcwb	31	32	the	the	DT
cord-316626-258rbcwb	31	33	risk	risk	NN
cord-316626-258rbcwb	31	34	of	of	IN
cord-316626-258rbcwb	31	35	infection	infection	NN
cord-316626-258rbcwb	31	36	.	.	.
cord-316626-258rbcwb	32	1	A	a	DT
cord-316626-258rbcwb	32	2	major	major	JJ
cord-316626-258rbcwb	32	3	strength	strength	NN
cord-316626-258rbcwb	32	4	of	of	IN
cord-316626-258rbcwb	32	5	the	the	DT
cord-316626-258rbcwb	32	6	study	study	NN
cord-316626-258rbcwb	32	7	is	be	VBZ
cord-316626-258rbcwb	32	8	to	to	TO
cord-316626-258rbcwb	32	9	employ	employ	VB
cord-316626-258rbcwb	32	10	a	a	DT
cord-316626-258rbcwb	32	11	Bayesian	bayesian	JJ
cord-316626-258rbcwb	32	12	framework	framework	NN
cord-316626-258rbcwb	32	13	,	,	,
cord-316626-258rbcwb	32	14	allowing	allow	VBG
cord-316626-258rbcwb	32	15	multiple	multiple	JJ
cord-316626-258rbcwb	32	16	interim	interim	JJ
cord-316626-258rbcwb	32	17	analyses	analysis	NNS
cord-316626-258rbcwb	32	18	,	,	,
cord-316626-258rbcwb	32	19	the	the	DT
cord-316626-258rbcwb	32	20	possibility	possibility	NN
cord-316626-258rbcwb	32	21	of	of	IN
cord-316626-258rbcwb	32	22	incorporating	incorporate	VBG
cord-316626-258rbcwb	32	23	new	new	JJ
cord-316626-258rbcwb	32	24	external	external	JJ
cord-316626-258rbcwb	32	25	evidence	evidence	NN
cord-316626-258rbcwb	32	26	,	,	,
cord-316626-258rbcwb	32	27	and	and	CC
cord-316626-258rbcwb	32	28	the	the	DT
cord-316626-258rbcwb	32	29	early	early	JJ
cord-316626-258rbcwb	32	30	stopping	stopping	NN
cord-316626-258rbcwb	32	31	of	of	IN
cord-316626-258rbcwb	32	32	the	the	DT
cord-316626-258rbcwb	32	33	trial	trial	NN
cord-316626-258rbcwb	32	34	according	accord	VBG
cord-316626-258rbcwb	32	35	to	to	IN
cord-316626-258rbcwb	32	36	predefined	predefined	JJ
cord-316626-258rbcwb	32	37	probabilities	probability	NNS
cord-316626-258rbcwb	32	38	of	of	IN
cord-316626-258rbcwb	32	39	benefit	benefit	NN
cord-316626-258rbcwb	32	40	or	or	CC
cord-316626-258rbcwb	32	41	futility	futility	NN
cord-316626-258rbcwb	32	42	.	.	.
cord-316626-258rbcwb	33	1	In	in	IN
cord-316626-258rbcwb	33	2	the	the	DT
cord-316626-258rbcwb	33	3	last	last	JJ
cord-316626-258rbcwb	33	4	10	10	CD
cord-316626-258rbcwb	33	5	years	year	NNS
cord-316626-258rbcwb	33	6	,	,	,
cord-316626-258rbcwb	33	7	Bayesian	bayesian	JJ
cord-316626-258rbcwb	33	8	adaptive	adaptive	JJ
cord-316626-258rbcwb	33	9	clinical	clinical	JJ
cord-316626-258rbcwb	33	10	trials	trial	NNS
cord-316626-258rbcwb	33	11	have	have	VBP
cord-316626-258rbcwb	33	12	been	be	VBN
cord-316626-258rbcwb	33	13	increasingly	increasingly	RB
cord-316626-258rbcwb	33	14	used	use	VBN
cord-316626-258rbcwb	33	15	to	to	TO
cord-316626-258rbcwb	33	16	hasten	hasten	VB
cord-316626-258rbcwb	33	17	the	the	DT
cord-316626-258rbcwb	33	18	overall	overall	JJ
cord-316626-258rbcwb	33	19	trial	trial	NN
cord-316626-258rbcwb	33	20	process	process	NN
cord-316626-258rbcwb	33	21	(	(	-LRB-
cord-316626-258rbcwb	33	22	10	10	CD
cord-316626-258rbcwb	33	23	,	,	,
cord-316626-258rbcwb	33	24	11	11	CD
cord-316626-258rbcwb	33	25	)	)	-RRB-
cord-316626-258rbcwb	33	26	.	.	.
cord-316626-258rbcwb	34	1	In	in	IN
cord-316626-258rbcwb	34	2	general	general	JJ
cord-316626-258rbcwb	34	3	,	,	,
cord-316626-258rbcwb	34	4	these	these	DT
cord-316626-258rbcwb	34	5	studies	study	NNS
cord-316626-258rbcwb	34	6	share	share	VBP
cord-316626-258rbcwb	34	7	common	common	JJ
cord-316626-258rbcwb	34	8	features	feature	NNS
cord-316626-258rbcwb	34	9	,	,	,
cord-316626-258rbcwb	34	10	especially	especially	RB
cord-316626-258rbcwb	34	11	algorithms	algorithm	NNS
cord-316626-258rbcwb	34	12	to	to	TO
cord-316626-258rbcwb	34	13	greatly	greatly	RB
cord-316626-258rbcwb	34	14	reduce	reduce	VB
cord-316626-258rbcwb	34	15	the	the	DT
cord-316626-258rbcwb	34	16	sample	sample	NN
cord-316626-258rbcwb	34	17	size	size	NN
cord-316626-258rbcwb	34	18	needed	need	VBN
cord-316626-258rbcwb	34	19	to	to	TO
cord-316626-258rbcwb	34	20	assess	assess	VB
cord-316626-258rbcwb	34	21	the	the	DT
cord-316626-258rbcwb	34	22	intervention	intervention	NN
cord-316626-258rbcwb	34	23	without	without	IN
cord-316626-258rbcwb	34	24	lowering	lower	VBG
cord-316626-258rbcwb	34	25	the	the	DT
cord-316626-258rbcwb	34	26	statistical	statistical	JJ
cord-316626-258rbcwb	34	27	power	power	NN
cord-316626-258rbcwb	34	28	of	of	IN
cord-316626-258rbcwb	34	29	the	the	DT
cord-316626-258rbcwb	34	30	study	study	NN
cord-316626-258rbcwb	34	31	.	.	.
cord-316626-258rbcwb	35	1	As	as	IN
cord-316626-258rbcwb	35	2	a	a	DT
cord-316626-258rbcwb	35	3	result	result	NN
cord-316626-258rbcwb	35	4	,	,	,
cord-316626-258rbcwb	35	5	interventions	intervention	NNS
cord-316626-258rbcwb	35	6	can	can	MD
cord-316626-258rbcwb	35	7	progress	progress	VB
cord-316626-258rbcwb	35	8	more	more	RBR
cord-316626-258rbcwb	35	9	quickly	quickly	RB
cord-316626-258rbcwb	35	10	through	through	IN
cord-316626-258rbcwb	35	11	all	all	PDT
cord-316626-258rbcwb	35	12	the	the	DT
cord-316626-258rbcwb	35	13	processes	process	NNS
cord-316626-258rbcwb	35	14	,	,	,
cord-316626-258rbcwb	35	15	which	which	WDT
cord-316626-258rbcwb	35	16	is	be	VBZ
cord-316626-258rbcwb	35	17	urgently	urgently	RB
cord-316626-258rbcwb	35	18	needed	need	VBN
cord-316626-258rbcwb	35	19	and	and	CC
cord-316626-258rbcwb	35	20	of	of	IN
cord-316626-258rbcwb	35	21	utmost	utmost	JJ
cord-316626-258rbcwb	35	22	importance	importance	NN
cord-316626-258rbcwb	35	23	during	during	IN
cord-316626-258rbcwb	35	24	a	a	DT
cord-316626-258rbcwb	35	25	pandemic	pandemic	NN
cord-316626-258rbcwb	35	26	.	.	.
cord-316626-258rbcwb	36	1	A	a	DT
cord-316626-258rbcwb	36	2	quick	quick	JJ
cord-316626-258rbcwb	36	3	approval	approval	NN
cord-316626-258rbcwb	36	4	of	of	IN
cord-316626-258rbcwb	36	5	a	a	DT
cord-316626-258rbcwb	36	6	potential	potential	JJ
cord-316626-258rbcwb	36	7	intervention	intervention	NN
cord-316626-258rbcwb	36	8	is	be	VBZ
cord-316626-258rbcwb	36	9	expected	expect	VBN
cord-316626-258rbcwb	36	10	by	by	IN
cord-316626-258rbcwb	36	11	policymakers	policymaker	NNS
cord-316626-258rbcwb	36	12	and	and	CC
cord-316626-258rbcwb	36	13	consumers	consumer	NNS
cord-316626-258rbcwb	36	14	,	,	,
cord-316626-258rbcwb	36	15	as	as	IN
cord-316626-258rbcwb	36	16	early	early	JJ
cord-316626-258rbcwb	36	17	use	use	NN
cord-316626-258rbcwb	36	18	of	of	IN
cord-316626-258rbcwb	36	19	an	an	DT
cord-316626-258rbcwb	36	20	effective	effective	JJ
cord-316626-258rbcwb	36	21	treatment	treatment	NN
cord-316626-258rbcwb	36	22	may	may	MD
cord-316626-258rbcwb	36	23	improve	improve	VB
cord-316626-258rbcwb	36	24	patient	patient	JJ
cord-316626-258rbcwb	36	25	outcomes	outcome	NNS
cord-316626-258rbcwb	36	26	and	and	CC
cord-316626-258rbcwb	36	27	prevent	prevent	VB
cord-316626-258rbcwb	36	28	harm	harm	NN
cord-316626-258rbcwb	36	29	.	.	.
cord-316626-258rbcwb	37	1	However	however	RB
cord-316626-258rbcwb	37	2	,	,	,
cord-316626-258rbcwb	37	3	the	the	DT
cord-316626-258rbcwb	37	4	risk	risk	NN
cord-316626-258rbcwb	37	5	of	of	IN
cord-316626-258rbcwb	37	6	approving	approve	VBG
cord-316626-258rbcwb	37	7	an	an	DT
cord-316626-258rbcwb	37	8	ineffective	ineffective	JJ
cord-316626-258rbcwb	37	9	or	or	CC
cord-316626-258rbcwb	37	10	unsafe	unsafe	JJ
cord-316626-258rbcwb	37	11	intervention	intervention	NN
cord-316626-258rbcwb	37	12	is	be	VBZ
cord-316626-258rbcwb	37	13	not	not	RB
cord-316626-258rbcwb	37	14	often	often	RB
cord-316626-258rbcwb	37	15	considered	consider	VBN
cord-316626-258rbcwb	37	16	.	.	.
cord-316626-258rbcwb	38	1	Indeed	indeed	RB
cord-316626-258rbcwb	38	2	,	,	,
cord-316626-258rbcwb	38	3	withdrawing	withdraw	VBG
cord-316626-258rbcwb	38	4	an	an	DT
cord-316626-258rbcwb	38	5	approved	approve	VBN
cord-316626-258rbcwb	38	6	therapy	therapy	NN
cord-316626-258rbcwb	38	7	can	can	MD
cord-316626-258rbcwb	38	8	be	be	VB
cord-316626-258rbcwb	38	9	challenging	challenging	JJ
cord-316626-258rbcwb	38	10	,	,	,
cord-316626-258rbcwb	38	11	disruptive	disruptive	JJ
cord-316626-258rbcwb	38	12	,	,	,
cord-316626-258rbcwb	38	13	and	and	CC
cord-316626-258rbcwb	38	14	sometimes	sometimes	RB
cord-316626-258rbcwb	38	15	impractical	impractical	JJ
cord-316626-258rbcwb	38	16	.	.	.
cord-316626-258rbcwb	39	1	The	the	DT
cord-316626-258rbcwb	39	2	ORCHID	ORCHID	NNP
cord-316626-258rbcwb	39	3	trial	trial	NN
cord-316626-258rbcwb	39	4	investigators	investigator	NNS
cord-316626-258rbcwb	39	5	expect	expect	VBP
cord-316626-258rbcwb	39	6	to	to	TO
cord-316626-258rbcwb	39	7	finish	finish	VB
cord-316626-258rbcwb	39	8	the	the	DT
cord-316626-258rbcwb	39	9	study	study	NN
cord-316626-258rbcwb	39	10	with	with	IN
cord-316626-258rbcwb	39	11	a	a	DT
cord-316626-258rbcwb	39	12	sample	sample	NN
cord-316626-258rbcwb	39	13	size	size	NN
cord-316626-258rbcwb	39	14	of	of	IN
cord-316626-258rbcwb	39	15	510	510	CD
cord-316626-258rbcwb	39	16	patients	patient	NNS
cord-316626-258rbcwb	39	17	,	,	,
cord-316626-258rbcwb	39	18	which	which	WDT
cord-316626-258rbcwb	39	19	is	be	VBZ
cord-316626-258rbcwb	39	20	realistic	realistic	JJ
cord-316626-258rbcwb	39	21	and	and	CC
cord-316626-258rbcwb	39	22	acceptable	acceptable	JJ
cord-316626-258rbcwb	39	23	as	as	IN
cord-316626-258rbcwb	39	24	the	the	DT
cord-316626-258rbcwb	39	25	United	United	NNP
cord-316626-258rbcwb	39	26	States	States	NNP
cord-316626-258rbcwb	39	27	of	of	IN
cord-316626-258rbcwb	39	28	America	America	NNP
cord-316626-258rbcwb	39	29	currently	currently	RB
cord-316626-258rbcwb	39	30	has	have	VBZ
cord-316626-258rbcwb	39	31	z20,000	z20,000	DT
cord-316626-258rbcwb	39	32	new	new	JJ
cord-316626-258rbcwb	39	33	cases	case	NNS
cord-316626-258rbcwb	39	34	a	a	DT
cord-316626-258rbcwb	39	35	day	day	NN
cord-316626-258rbcwb	39	36	.	.	.
cord-316626-258rbcwb	40	1	In	in	IN
cord-316626-258rbcwb	40	2	a	a	DT
cord-316626-258rbcwb	40	3	recent	recent	JJ
cord-316626-258rbcwb	40	4	simulation	simulation	NN
cord-316626-258rbcwb	40	5	study	study	NN
cord-316626-258rbcwb	40	6	(	(	-LRB-
cord-316626-258rbcwb	40	7	14	14	CD
cord-316626-258rbcwb	40	8	)	)	-RRB-
cord-316626-258rbcwb	40	9	,	,	,
cord-316626-258rbcwb	40	10	the	the	DT
cord-316626-258rbcwb	40	11	optimal	optimal	JJ
cord-316626-258rbcwb	40	12	sample	sample	NN
cord-316626-258rbcwb	40	13	size	size	NN
cord-316626-258rbcwb	40	14	for	for	IN
cord-316626-258rbcwb	40	15	clinical	clinical	JJ
cord-316626-258rbcwb	40	16	trials	trial	NNS
cord-316626-258rbcwb	40	17	decrease	decrease	VBP
cord-316626-258rbcwb	40	18	with	with	IN
cord-316626-258rbcwb	40	19	the	the	DT
cord-316626-258rbcwb	40	20	infectivity	infectivity	NN
cord-316626-258rbcwb	40	21	of	of	IN
cord-316626-258rbcwb	40	22	the	the	DT
cord-316626-258rbcwb	40	23	epidemic	epidemic	NN
cord-316626-258rbcwb	40	24	.	.	.
cord-316626-258rbcwb	41	1	This	this	DT
cord-316626-258rbcwb	41	2	suggests	suggest	VBZ
cord-316626-258rbcwb	41	3	that	that	IN
cord-316626-258rbcwb	41	4	a	a	DT
cord-316626-258rbcwb	41	5	Bayesian	bayesian	JJ
cord-316626-258rbcwb	41	6	adaptive	adaptive	JJ
cord-316626-258rbcwb	41	7	design	design	NN
cord-316626-258rbcwb	41	8	allows	allow	VBZ
cord-316626-258rbcwb	41	9	the	the	DT
cord-316626-258rbcwb	41	10	flexibility	flexibility	NN
cord-316626-258rbcwb	41	11	needed	need	VBN
cord-316626-258rbcwb	41	12	to	to	TO
cord-316626-258rbcwb	41	13	adapt	adapt	VB
cord-316626-258rbcwb	41	14	the	the	DT
cord-316626-258rbcwb	41	15	study	study	NN
cord-316626-258rbcwb	41	16	to	to	IN
cord-316626-258rbcwb	41	17	specific	specific	JJ
cord-316626-258rbcwb	41	18	parameters	parameter	NNS
cord-316626-258rbcwb	41	19	and	and	CC
cord-316626-258rbcwb	41	20	stages	stage	NNS
cord-316626-258rbcwb	41	21	of	of	IN
cord-316626-258rbcwb	41	22	the	the	DT
cord-316626-258rbcwb	41	23	epidemic	epidemic	NN
cord-316626-258rbcwb	41	24	.	.	.
cord-316626-258rbcwb	42	1	One	one	CD
cord-316626-258rbcwb	42	2	potential	potential	JJ
cord-316626-258rbcwb	42	3	limitation	limitation	NN
cord-316626-258rbcwb	42	4	of	of	IN
cord-316626-258rbcwb	42	5	ORCHID	ORCHID	NNP
cord-316626-258rbcwb	42	6	trial	trial	NN
cord-316626-258rbcwb	42	7	,	,	,
cord-316626-258rbcwb	42	8	and	and	CC
cord-316626-258rbcwb	42	9	several	several	JJ
cord-316626-258rbcwb	42	10	other	other	JJ
cord-316626-258rbcwb	42	11	trials	trial	NNS
cord-316626-258rbcwb	42	12	testing	test	VBG
cord-316626-258rbcwb	42	13	therapies	therapy	NNS
cord-316626-258rbcwb	42	14	in	in	IN
cord-316626-258rbcwb	42	15	COVID-19	COVID-19	NNP
cord-316626-258rbcwb	42	16	,	,	,
cord-316626-258rbcwb	42	17	is	be	VBZ
cord-316626-258rbcwb	42	18	evaluation	evaluation	NN
cord-316626-258rbcwb	42	19	of	of	IN
cord-316626-258rbcwb	42	20	the	the	DT
cord-316626-258rbcwb	42	21	primary	primary	JJ
cord-316626-258rbcwb	42	22	outcome	outcome	NN
cord-316626-258rbcwb	42	23	in	in	IN
cord-316626-258rbcwb	42	24	a	a	DT
cord-316626-258rbcwb	42	25	short	short	JJ
cord-316626-258rbcwb	42	26	time	time	NN
cord-316626-258rbcwb	42	27	frame	frame	NN
cord-316626-258rbcwb	42	28	.	.	.
cord-316626-258rbcwb	43	1	Though	though	IN
cord-316626-258rbcwb	43	2	understandable	understandable	JJ
cord-316626-258rbcwb	43	3	because	because	IN
cord-316626-258rbcwb	43	4	of	of	IN
cord-316626-258rbcwb	43	5	the	the	DT
cord-316626-258rbcwb	43	6	urgent	urgent	JJ
cord-316626-258rbcwb	43	7	need	need	NN
cord-316626-258rbcwb	43	8	for	for	IN
cord-316626-258rbcwb	43	9	answers	answer	NNS
cord-316626-258rbcwb	43	10	,	,	,
cord-316626-258rbcwb	43	11	we	-PRON-	PRP
cord-316626-258rbcwb	43	12	have	have	VBP
cord-316626-258rbcwb	43	13	learned	learn	VBN
cord-316626-258rbcwb	43	14	that	that	IN
cord-316626-258rbcwb	43	15	these	these	DT
cord-316626-258rbcwb	43	16	patients	patient	NNS
cord-316626-258rbcwb	43	17	usually	usually	RB
cord-316626-258rbcwb	43	18	have	have	VBP
cord-316626-258rbcwb	43	19	a	a	DT
cord-316626-258rbcwb	43	20	longer	long	RBR
cord-316626-258rbcwb	43	21	convalescent	convalescent	JJ
cord-316626-258rbcwb	43	22	period	period	NN
cord-316626-258rbcwb	43	23	.	.	.
cord-316626-258rbcwb	44	1	Fifteen	fifteen	CD
cord-316626-258rbcwb	44	2	days	day	NNS
cord-316626-258rbcwb	44	3	is	be	VBZ
cord-316626-258rbcwb	44	4	relatively	relatively	RB
cord-316626-258rbcwb	44	5	short	short	JJ
cord-316626-258rbcwb	44	6	and	and	CC
cord-316626-258rbcwb	44	7	may	may	MD
cord-316626-258rbcwb	44	8	not	not	RB
cord-316626-258rbcwb	44	9	accurately	accurately	RB
cord-316626-258rbcwb	44	10	capture	capture	VB
cord-316626-258rbcwb	44	11	the	the	DT
cord-316626-258rbcwb	44	12	majority	majority	NN
cord-316626-258rbcwb	44	13	of	of	IN
cord-316626-258rbcwb	44	14	patients	patient	NNS
cord-316626-258rbcwb	44	15	who	who	WP
cord-316626-258rbcwb	44	16	have	have	VBP
cord-316626-258rbcwb	44	17	died	die	VBN
cord-316626-258rbcwb	44	18	or	or	CC
cord-316626-258rbcwb	44	19	recovered	recover	VBN
cord-316626-258rbcwb	44	20	.	.	.
cord-316626-258rbcwb	45	1	A	a	DT
cord-316626-258rbcwb	45	2	longer	long	JJR
cord-316626-258rbcwb	45	3	period	period	NN
cord-316626-258rbcwb	45	4	of	of	IN
cord-316626-258rbcwb	45	5	observation	observation	NN
cord-316626-258rbcwb	45	6	is	be	VBZ
cord-316626-258rbcwb	45	7	somewhat	somewhat	RB
cord-316626-258rbcwb	45	8	problematic	problematic	JJ
cord-316626-258rbcwb	45	9	when	when	WRB
cord-316626-258rbcwb	45	10	there	there	EX
cord-316626-258rbcwb	45	11	is	be	VBZ
cord-316626-258rbcwb	45	12	very	very	RB
cord-316626-258rbcwb	45	13	rapid	rapid	JJ
cord-316626-258rbcwb	45	14	randomization	randomization	NN
cord-316626-258rbcwb	45	15	,	,	,
cord-316626-258rbcwb	45	16	such	such	JJ
cord-316626-258rbcwb	45	17	as	as	IN
cord-316626-258rbcwb	45	18	during	during	IN
cord-316626-258rbcwb	45	19	the	the	DT
cord-316626-258rbcwb	45	20	pandemic	pandemic	NN
cord-316626-258rbcwb	45	21	,	,	,
cord-316626-258rbcwb	45	22	as	as	IN
cord-316626-258rbcwb	45	23	it	-PRON-	PRP
cord-316626-258rbcwb	45	24	delays	delay	VBZ
cord-316626-258rbcwb	45	25	the	the	DT
cord-316626-258rbcwb	45	26	trial	trial	NN
cord-316626-258rbcwb	45	27	results	result	NNS
cord-316626-258rbcwb	45	28	.	.	.
cord-316626-258rbcwb	46	1	This	this	DT
cord-316626-258rbcwb	46	2	may	may	MD
cord-316626-258rbcwb	46	3	interfere	interfere	VB
cord-316626-258rbcwb	46	4	with	with	IN
cord-316626-258rbcwb	46	5	the	the	DT
cord-316626-258rbcwb	46	6	interim	interim	JJ
cord-316626-258rbcwb	46	7	analyses	analysis	NNS
cord-316626-258rbcwb	46	8	,	,	,
cord-316626-258rbcwb	46	9	as	as	IN
cord-316626-258rbcwb	46	10	many	many	JJ
cord-316626-258rbcwb	46	11	randomized	randomized	JJ
cord-316626-258rbcwb	46	12	patients	patient	NNS
cord-316626-258rbcwb	46	13	will	will	MD
cord-316626-258rbcwb	46	14	not	not	RB
cord-316626-258rbcwb	46	15	have	have	VB
cord-316626-258rbcwb	46	16	a	a	DT
cord-316626-258rbcwb	46	17	measure	measure	NN
cord-316626-258rbcwb	46	18	of	of	IN
cord-316626-258rbcwb	46	19	the	the	DT
cord-316626-258rbcwb	46	20	outcome	outcome	NN
cord-316626-258rbcwb	46	21	of	of	IN
cord-316626-258rbcwb	46	22	interest	interest	NN
cord-316626-258rbcwb	46	23	,	,	,
cord-316626-258rbcwb	46	24	making	make	VBG
cord-316626-258rbcwb	46	25	it	-PRON-	PRP
cord-316626-258rbcwb	46	26	difficult	difficult	JJ
cord-316626-258rbcwb	46	27	for	for	IN
cord-316626-258rbcwb	46	28	the	the	DT
cord-316626-258rbcwb	46	29	data	data	NN
cord-316626-258rbcwb	46	30	safety	safety	NN
cord-316626-258rbcwb	46	31	and	and	CC
cord-316626-258rbcwb	46	32	monitoring	monitoring	NN
cord-316626-258rbcwb	46	33	committee	committee	NN
cord-316626-258rbcwb	46	34	to	to	TO
cord-316626-258rbcwb	46	35	recommend	recommend	VB
cord-316626-258rbcwb	46	36	stopping	stop	VBG
cord-316626-258rbcwb	46	37	the	the	DT
cord-316626-258rbcwb	46	38	trial	trial	NN
cord-316626-258rbcwb	46	39	if	if	IN
cord-316626-258rbcwb	46	40	required	require	VBN
cord-316626-258rbcwb	46	41	.	.	.
cord-316626-258rbcwb	47	1	In	in	IN
cord-316626-258rbcwb	47	2	this	this	DT
cord-316626-258rbcwb	47	3	time	time	NN
cord-316626-258rbcwb	47	4	of	of	IN
cord-316626-258rbcwb	47	5	uncertainty	uncertainty	NN
cord-316626-258rbcwb	47	6	,	,	,
cord-316626-258rbcwb	47	7	when	when	WRB
cord-316626-258rbcwb	47	8	clinicians	clinician	NNS
cord-316626-258rbcwb	47	9	are	be	VBP
cord-316626-258rbcwb	47	10	desperately	desperately	RB
cord-316626-258rbcwb	47	11	seeking	seek	VBG
cord-316626-258rbcwb	47	12	effective	effective	JJ
cord-316626-258rbcwb	47	13	therapies	therapy	NNS
cord-316626-258rbcwb	47	14	to	to	TO
cord-316626-258rbcwb	47	15	fight	fight	VB
cord-316626-258rbcwb	47	16	COVID-19	COVID-19	NNP
cord-316626-258rbcwb	47	17	,	,	,
cord-316626-258rbcwb	47	18	the	the	DT
cord-316626-258rbcwb	47	19	ORCHID	ORCHID	NNP
cord-316626-258rbcwb	47	20	trial	trial	NN
cord-316626-258rbcwb	47	21	provides	provide	VBZ
cord-316626-258rbcwb	47	22	several	several	JJ
cord-316626-258rbcwb	47	23	unique	unique	JJ
cord-316626-258rbcwb	47	24	solutions	solution	NNS
cord-316626-258rbcwb	47	25	to	to	IN
cord-316626-258rbcwb	47	26	the	the	DT
cord-316626-258rbcwb	47	27	constraints	constraint	NNS
cord-316626-258rbcwb	47	28	of	of	IN
cord-316626-258rbcwb	47	29	traditional	traditional	JJ
cord-316626-258rbcwb	47	30	clinical	clinical	JJ
cord-316626-258rbcwb	47	31	trials	trial	NNS
cord-316626-258rbcwb	47	32	.	.	.
cord-316626-258rbcwb	48	1	These	these	DT
cord-316626-258rbcwb	48	2	include	include	VBP
cord-316626-258rbcwb	48	3	processes	process	NNS
cord-316626-258rbcwb	48	4	for	for	IN
cord-316626-258rbcwb	48	5	rapid	rapid	JJ
cord-316626-258rbcwb	48	6	administrative	administrative	JJ
cord-316626-258rbcwb	48	7	and	and	CC
cord-316626-258rbcwb	48	8	regulatory	regulatory	JJ
cord-316626-258rbcwb	48	9	approvals	approval	NNS
cord-316626-258rbcwb	48	10	,	,	,
cord-316626-258rbcwb	48	11	production	production	NN
cord-316626-258rbcwb	48	12	of	of	IN
cord-316626-258rbcwb	48	13	visually	visually	RB
cord-316626-258rbcwb	48	14	identical	identical	JJ
cord-316626-258rbcwb	48	15	placebo	placebo	NN
cord-316626-258rbcwb	48	16	pills	pill	NNS
cord-316626-258rbcwb	48	17	,	,	,
cord-316626-258rbcwb	48	18	the	the	DT
cord-316626-258rbcwb	48	19	use	use	NN
cord-316626-258rbcwb	48	20	of	of	IN
cord-316626-258rbcwb	48	21	interactive	interactive	JJ
cord-316626-258rbcwb	48	22	platforms	platform	NNS
cord-316626-258rbcwb	48	23	for	for	IN
cord-316626-258rbcwb	48	24	informed	informed	JJ
cord-316626-258rbcwb	48	25	consent	consent	NN
cord-316626-258rbcwb	48	26	,	,	,
cord-316626-258rbcwb	48	27	and	and	CC
cord-316626-258rbcwb	48	28	flexible	flexible	JJ
cord-316626-258rbcwb	48	29	Bayesian	bayesian	JJ
cord-316626-258rbcwb	48	30	trial	trial	NN
cord-316626-258rbcwb	48	31	design	design	NN
cord-316626-258rbcwb	48	32	.	.	.
cord-316626-258rbcwb	49	1	Studies	study	NNS
cord-316626-258rbcwb	49	2	like	like	IN
cord-316626-258rbcwb	49	3	the	the	DT
cord-316626-258rbcwb	49	4	ORCHID	ORCHID	NNP
cord-316626-258rbcwb	49	5	trial	trial	NN
cord-316626-258rbcwb	49	6	,	,	,
cord-316626-258rbcwb	49	7	and	and	CC
cord-316626-258rbcwb	49	8	others	other	NNS
cord-316626-258rbcwb	49	9	in	in	IN
cord-316626-258rbcwb	49	10	the	the	DT
cord-316626-258rbcwb	49	11	field	field	NN
cord-316626-258rbcwb	49	12	,	,	,
cord-316626-258rbcwb	49	13	are	be	VBP
cord-316626-258rbcwb	49	14	a	a	DT
cord-316626-258rbcwb	49	15	whisper	whisper	NN
cord-316626-258rbcwb	49	16	of	of	IN
cord-316626-258rbcwb	49	17	rationality	rationality	NN
cord-316626-258rbcwb	49	18	during	during	IN
cord-316626-258rbcwb	49	19	irrational	irrational	JJ
cord-316626-258rbcwb	49	20	times	time	NNS
cord-316626-258rbcwb	49	21	and	and	CC
cord-316626-258rbcwb	49	22	rekindle	rekindle	VB
cord-316626-258rbcwb	49	23	the	the	DT
cord-316626-258rbcwb	49	24	hope	hope	NN
cord-316626-258rbcwb	49	25	that	that	IN
cord-316626-258rbcwb	49	26	evidence	evidence	NN
cord-316626-258rbcwb	49	27	-	-	HYPH
cord-316626-258rbcwb	49	28	based	base	VBN
cord-316626-258rbcwb	49	29	medicine	medicine	NN
cord-316626-258rbcwb	49	30	will	will	MD
cord-316626-258rbcwb	49	31	survive	survive	VB
cord-316626-258rbcwb	49	32	the	the	DT
cord-316626-258rbcwb	49	33	COVID-19	COVID-19	NNP
cord-316626-258rbcwb	49	34	pandemic	pandemic	NN
cord-316626-258rbcwb	49	35	.	.	.
cord-316626-258rbcwb	50	1	n	n	NNP
cord-316626-258rbcwb	51	1	In	in	IN
cord-316626-258rbcwb	51	2	defense	defense	NN
cord-316626-258rbcwb	51	3	of	of	IN
cord-316626-258rbcwb	51	4	evidence	evidence	NN
cord-316626-258rbcwb	51	5	-	-	HYPH
cord-316626-258rbcwb	51	6	based	base	VBN
cord-316626-258rbcwb	51	7	medicine	medicine	NN
cord-316626-258rbcwb	51	8	for	for	IN
cord-316626-258rbcwb	51	9	the	the	DT
cord-316626-258rbcwb	51	10	treatment	treatment	NN
cord-316626-258rbcwb	51	11	of	of	IN
cord-316626-258rbcwb	51	12	COVID-19	covid-19	JJ
cord-316626-258rbcwb	51	13	acute	acute	JJ
cord-316626-258rbcwb	51	14	respiratory	respiratory	JJ
cord-316626-258rbcwb	51	15	distress	distress	NN
cord-316626-258rbcwb	51	16	syndrome	syndrome	NN
cord-316626-258rbcwb	52	1	In	in	IN
cord-316626-258rbcwb	52	2	vitro	vitro	FW
cord-316626-258rbcwb	52	3	inhibition	inhibition	NN
cord-316626-258rbcwb	52	4	of	of	IN
cord-316626-258rbcwb	52	5	severe	severe	JJ
cord-316626-258rbcwb	52	6	acute	acute	JJ
cord-316626-258rbcwb	52	7	respiratory	respiratory	JJ
cord-316626-258rbcwb	52	8	syndrome	syndrome	NN
cord-316626-258rbcwb	52	9	coronavirus	coronavirus	NN
cord-316626-258rbcwb	52	10	by	by	IN
cord-316626-258rbcwb	52	11	chloroquine	chloroquine	NN
cord-316626-258rbcwb	52	12	Multicenter	Multicenter	NNP
cord-316626-258rbcwb	52	13	Collaboration	Collaboration	NNP
cord-316626-258rbcwb	52	14	Group	Group	NNP
cord-316626-258rbcwb	52	15	of	of	IN
cord-316626-258rbcwb	52	16	Department	Department	NNP
cord-316626-258rbcwb	52	17	of	of	IN
cord-316626-258rbcwb	52	18	Science	Science	NNP
cord-316626-258rbcwb	52	19	and	and	CC
cord-316626-258rbcwb	52	20	Technology	Technology	NNP
cord-316626-258rbcwb	52	21	of	of	IN
cord-316626-258rbcwb	52	22	Guangdong	Guangdong	NNP
cord-316626-258rbcwb	52	23	Province	Province	NNP
cord-316626-258rbcwb	52	24	and	and	CC
cord-316626-258rbcwb	52	25	Health	Health	NNP
cord-316626-258rbcwb	52	26	Commission	Commission	NNP
cord-316626-258rbcwb	52	27	of	of	IN
cord-316626-258rbcwb	52	28	Guangdong	Guangdong	NNP
cord-316626-258rbcwb	52	29	Province	Province	NNP
cord-316626-258rbcwb	52	30	for	for	IN
cord-316626-258rbcwb	52	31	Chloroquine	Chloroquine	NNP
cord-316626-258rbcwb	52	32	in	in	IN
cord-316626-258rbcwb	52	33	the	the	DT
cord-316626-258rbcwb	52	34	Treatment	Treatment	NNP
cord-316626-258rbcwb	52	35	of	of	IN
cord-316626-258rbcwb	52	36	Novel	Novel	NNP
cord-316626-258rbcwb	52	37	Coronavirus	Coronavirus	NNP
cord-316626-258rbcwb	52	38	Pneumonia	Pneumonia	NNP
cord-316626-258rbcwb	52	39	.	.	.
cord-316626-258rbcwb	53	1	Expert	expert	NN
cord-316626-258rbcwb	53	2	consensus	consensus	NN
cord-316626-258rbcwb	53	3	on	on	IN
cord-316626-258rbcwb	53	4	chloroquine	chloroquine	NN
cord-316626-258rbcwb	53	5	phosphate	phosphate	NN
cord-316626-258rbcwb	53	6	for	for	IN
cord-316626-258rbcwb	53	7	the	the	DT
cord-316626-258rbcwb	53	8	treatment	treatment	NN
cord-316626-258rbcwb	53	9	of	of	IN
cord-316626-258rbcwb	53	10	novel	novel	JJ
cord-316626-258rbcwb	53	11	coronavirus	coronavirus	NN
cord-316626-258rbcwb	53	12	pneumonia	pneumonia	NN
cord-316626-258rbcwb	53	13	Chloroquine	Chloroquine	NNP
cord-316626-258rbcwb	53	14	for	for	IN
cord-316626-258rbcwb	53	15	influenza	influenza	NN
cord-316626-258rbcwb	53	16	prevention	prevention	NN
cord-316626-258rbcwb	53	17	:	:	:
cord-316626-258rbcwb	53	18	a	a	DT
cord-316626-258rbcwb	53	19	randomised	randomised	JJ
cord-316626-258rbcwb	53	20	,	,	,
cord-316626-258rbcwb	53	21	double	double	JJ
cord-316626-258rbcwb	53	22	-	-	HYPH
cord-316626-258rbcwb	53	23	blind	blind	JJ
cord-316626-258rbcwb	53	24	,	,	,
cord-316626-258rbcwb	53	25	placebo	placebo	NN
cord-316626-258rbcwb	53	26	controlled	control	VBN
cord-316626-258rbcwb	53	27	trial	trial	NN
cord-316626-258rbcwb	53	28	A	a	DT
cord-316626-258rbcwb	53	29	randomized	randomized	JJ
cord-316626-258rbcwb	53	30	controlled	control	VBN
cord-316626-258rbcwb	53	31	trial	trial	NN
cord-316626-258rbcwb	53	32	of	of	IN
cord-316626-258rbcwb	53	33	chloroquine	chloroquine	NN
cord-316626-258rbcwb	53	34	for	for	IN
cord-316626-258rbcwb	53	35	the	the	DT
cord-316626-258rbcwb	53	36	treatment	treatment	NN
cord-316626-258rbcwb	53	37	of	of	IN
cord-316626-258rbcwb	53	38	dengue	dengue	NN
cord-316626-258rbcwb	53	39	in	in	IN
cord-316626-258rbcwb	53	40	Vietnamese	vietnamese	JJ
cord-316626-258rbcwb	53	41	adults	adult	NNS
cord-316626-258rbcwb	53	42	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-316626-258rbcwb	53	43	Trial	Trial	NNP
cord-316626-258rbcwb	53	44	Team	Team	NNP
cord-316626-258rbcwb	53	45	.	.	.
cord-316626-258rbcwb	54	1	Effects	effect	NNS
cord-316626-258rbcwb	54	2	of	of	IN
cord-316626-258rbcwb	54	3	hydroxychloroquine	hydroxychloroquine	NN
cord-316626-258rbcwb	54	4	on	on	IN
cord-316626-258rbcwb	54	5	immune	immune	JJ
cord-316626-258rbcwb	54	6	activation	activation	NN
cord-316626-258rbcwb	54	7	and	and	CC
cord-316626-258rbcwb	54	8	disease	disease	NN
cord-316626-258rbcwb	54	9	progression	progression	NN
cord-316626-258rbcwb	54	10	among	among	IN
cord-316626-258rbcwb	54	11	HIV	HIV	NNP
cord-316626-258rbcwb	54	12	-	-	HYPH
cord-316626-258rbcwb	54	13	infected	infect	VBN
cord-316626-258rbcwb	54	14	patients	patient	NNS
cord-316626-258rbcwb	54	15	not	not	RB
cord-316626-258rbcwb	54	16	receiving	receive	VBG
cord-316626-258rbcwb	54	17	antiretroviral	antiretroviral	JJ
cord-316626-258rbcwb	54	18	therapy	therapy	NN
cord-316626-258rbcwb	54	19	:	:	:
cord-316626-258rbcwb	54	20	a	a	DT
cord-316626-258rbcwb	54	21	randomized	randomized	JJ
cord-316626-258rbcwb	54	22	controlled	control	VBN
cord-316626-258rbcwb	54	23	trial	trial	NN
cord-316626-258rbcwb	54	24	Association	Association	NNP
cord-316626-258rbcwb	54	25	of	of	IN
cord-316626-258rbcwb	54	26	treatment	treatment	NN
cord-316626-258rbcwb	54	27	with	with	IN
cord-316626-258rbcwb	54	28	hydroxychloroquine	hydroxychloroquine	NNP
cord-316626-258rbcwb	54	29	or	or	CC
cord-316626-258rbcwb	54	30	azithromycin	azithromycin	NN
cord-316626-258rbcwb	54	31	with	with	IN
cord-316626-258rbcwb	54	32	in	in	IN
cord-316626-258rbcwb	54	33	-	-	HYPH
cord-316626-258rbcwb	54	34	hospital	hospital	NN
cord-316626-258rbcwb	54	35	mortality	mortality	NN
cord-316626-258rbcwb	54	36	in	in	IN
cord-316626-258rbcwb	54	37	patients	patient	NNS
cord-316626-258rbcwb	54	38	with	with	IN
cord-316626-258rbcwb	54	39	COVID-19	covid-19	CD
cord-316626-258rbcwb	54	40	in	in	IN
cord-316626-258rbcwb	54	41	New	New	NNP
cord-316626-258rbcwb	54	42	York	York	NNP
cord-316626-258rbcwb	54	43	state	state	NN
cord-316626-258rbcwb	54	44	Observational	observational	JJ
cord-316626-258rbcwb	54	45	study	study	NN
cord-316626-258rbcwb	54	46	of	of	IN
cord-316626-258rbcwb	54	47	hydroxychloroquine	hydroxychloroquine	NNP
cord-316626-258rbcwb	54	48	in	in	IN
cord-316626-258rbcwb	54	49	hospitalized	hospitalize	VBN
cord-316626-258rbcwb	54	50	patients	patient	NNS
cord-316626-258rbcwb	54	51	with	with	IN
cord-316626-258rbcwb	54	52	Covid-19	Covid-19	NNP
cord-316626-258rbcwb	54	53	Effect	Effect	NNP
cord-316626-258rbcwb	54	54	of	of	IN
cord-316626-258rbcwb	54	55	high	high	JJ
cord-316626-258rbcwb	54	56	vs	vs	IN
cord-316626-258rbcwb	54	57	low	low	JJ
cord-316626-258rbcwb	54	58	doses	dose	NNS
cord-316626-258rbcwb	54	59	of	of	IN
cord-316626-258rbcwb	54	60	chloroquine	chloroquine	NN
cord-316626-258rbcwb	54	61	diphosphate	diphosphate	NN
cord-316626-258rbcwb	54	62	as	as	IN
cord-316626-258rbcwb	54	63	adjunctive	adjunctive	JJ
cord-316626-258rbcwb	54	64	therapy	therapy	NN
cord-316626-258rbcwb	54	65	for	for	IN
cord-316626-258rbcwb	54	66	patients	patient	NNS
cord-316626-258rbcwb	54	67	hospitalized	hospitalize	VBN
cord-316626-258rbcwb	54	68	with	with	IN
cord-316626-258rbcwb	54	69	severe	severe	JJ
cord-316626-258rbcwb	54	70	acute	acute	JJ
cord-316626-258rbcwb	54	71	respiratory	respiratory	JJ
cord-316626-258rbcwb	54	72	syndrome	syndrome	NN
cord-316626-258rbcwb	54	73	coronavirus	coronavirus	NN
cord-316626-258rbcwb	54	74	2	2	CD
cord-316626-258rbcwb	55	1	(	(	-LRB-
cord-316626-258rbcwb	55	2	SARS	SARS	NNP
cord-316626-258rbcwb	55	3	-	-	HYPH
cord-316626-258rbcwb	55	4	CoV-2	CoV-2	NNP
cord-316626-258rbcwb	55	5	)	)	-RRB-
cord-316626-258rbcwb	55	6	infection	infection	NN
cord-316626-258rbcwb	55	7	:	:	:
cord-316626-258rbcwb	55	8	a	a	DT
cord-316626-258rbcwb	55	9	randomized	randomized	JJ
cord-316626-258rbcwb	55	10	clinical	clinical	JJ
cord-316626-258rbcwb	55	11	trial	trial	NN
cord-316626-258rbcwb	55	12	Arguing	argue	VBG
cord-316626-258rbcwb	55	13	for	for	IN
cord-316626-258rbcwb	55	14	adaptive	adaptive	JJ
cord-316626-258rbcwb	55	15	clinical	clinical	JJ
cord-316626-258rbcwb	55	16	trials	trial	NNS
cord-316626-258rbcwb	55	17	in	in	IN
cord-316626-258rbcwb	55	18	sepsis	sepsis	NN
cord-316626-258rbcwb	55	19	Contemporary	contemporary	JJ
cord-316626-258rbcwb	55	20	strategies	strategy	NNS
cord-316626-258rbcwb	55	21	to	to	TO
cord-316626-258rbcwb	55	22	improve	improve	VB
cord-316626-258rbcwb	55	23	clinical	clinical	JJ
cord-316626-258rbcwb	55	24	trial	trial	NN
cord-316626-258rbcwb	55	25	design	design	NN
cord-316626-258rbcwb	55	26	for	for	IN
cord-316626-258rbcwb	55	27	critical	critical	JJ
cord-316626-258rbcwb	55	28	care	care	NN
cord-316626-258rbcwb	55	29	research	research	NN
cord-316626-258rbcwb	55	30	:	:	:
cord-316626-258rbcwb	55	31	insights	insight	NNS
cord-316626-258rbcwb	55	32	from	from	IN
cord-316626-258rbcwb	55	33	the	the	DT
cord-316626-258rbcwb	55	34	First	First	NNP
cord-316626-258rbcwb	55	35	Critical	Critical	NNP
cord-316626-258rbcwb	55	36	Care	Care	NNP
cord-316626-258rbcwb	55	37	Clinical	Clinical	NNP
cord-316626-258rbcwb	55	38	Trialists	Trialists	NNPS
cord-316626-258rbcwb	55	39	Workshop	Workshop	NNP
cord-316626-258rbcwb	55	40	Using	use	VBG
cord-316626-258rbcwb	55	41	Bayesian	bayesian	JJ
cord-316626-258rbcwb	55	42	adaptive	adaptive	JJ
cord-316626-258rbcwb	55	43	designs	design	NNS
cord-316626-258rbcwb	55	44	to	to	TO
cord-316626-258rbcwb	55	45	improve	improve	VB
cord-316626-258rbcwb	55	46	phase	phase	NN
cord-316626-258rbcwb	55	47	III	iii	CD
cord-316626-258rbcwb	55	48	trials	trial	NNS
cord-316626-258rbcwb	55	49	:	:	:
cord-316626-258rbcwb	55	50	a	a	DT
cord-316626-258rbcwb	55	51	respiratory	respiratory	JJ
cord-316626-258rbcwb	55	52	care	care	NN
cord-316626-258rbcwb	55	53	example	example	NN
cord-316626-258rbcwb	55	54	ORCHID	ORCHID	NNP
cord-316626-258rbcwb	55	55	Protocol	Protocol	NNP
cord-316626-258rbcwb	55	56	Committee	Committee	NNP
cord-316626-258rbcwb	55	57	and	and	CC
cord-316626-258rbcwb	55	58	the	the	DT
cord-316626-258rbcwb	55	59	National	National	NNP
cord-316626-258rbcwb	55	60	Heart	Heart	NNP
cord-316626-258rbcwb	55	61	,	,	,
cord-316626-258rbcwb	55	62	Lung	Lung	NNP
cord-316626-258rbcwb	55	63	,	,	,
cord-316626-258rbcwb	55	64	and	and	CC
cord-316626-258rbcwb	55	65	Blood	Blood	NNP
cord-316626-258rbcwb	55	66	Institute	Institute	NNP
cord-316626-258rbcwb	55	67	Prevention	Prevention	NNP
cord-316626-258rbcwb	55	68	and	and	CC
cord-316626-258rbcwb	55	69	Early	Early	NNP
cord-316626-258rbcwb	55	70	Treatment	Treatment	NNP
cord-316626-258rbcwb	55	71	of	of	IN
cord-316626-258rbcwb	55	72	Acute	Acute	NNP
cord-316626-258rbcwb	55	73	Lung	Lung	NNP
cord-316626-258rbcwb	55	74	Injury	injury	NN
cord-316626-258rbcwb	55	75	(	(	-LRB-
cord-316626-258rbcwb	55	76	PETAL	PETAL	NNP
cord-316626-258rbcwb	55	77	)	)	-RRB-
cord-316626-258rbcwb	55	78	Network	Network	NNP
cord-316626-258rbcwb	55	79	Investigators	Investigators	NNPS
cord-316626-258rbcwb	55	80	.	.	.
cord-316626-258rbcwb	56	1	Rationale	rationale	NN
cord-316626-258rbcwb	56	2	and	and	CC
cord-316626-258rbcwb	56	3	design	design	NN
cord-316626-258rbcwb	56	4	of	of	IN
cord-316626-258rbcwb	56	5	ORCHID	ORCHID	NNP
cord-316626-258rbcwb	56	6	:	:	:
cord-316626-258rbcwb	56	7	a	a	DT
cord-316626-258rbcwb	56	8	randomized	randomized	JJ
cord-316626-258rbcwb	56	9	placebo	placebo	NN
cord-316626-258rbcwb	56	10	-	-	HYPH
cord-316626-258rbcwb	56	11	controlled	control	VBN
cord-316626-258rbcwb	56	12	clinical	clinical	JJ
cord-316626-258rbcwb	56	13	trial	trial	NN
cord-316626-258rbcwb	56	14	of	of	IN
cord-316626-258rbcwb	56	15	hydroxychloroquine	hydroxychloroquine	NN
cord-316626-258rbcwb	56	16	for	for	IN
cord-316626-258rbcwb	56	17	adults	adult	NNS
cord-316626-258rbcwb	56	18	hospitalized	hospitalize	VBN
cord-316626-258rbcwb	56	19	with	with	IN
cord-316626-258rbcwb	56	20	COVID-19	covid-19	JJ
cord-316626-258rbcwb	56	21	Bayesian	bayesian	JJ
cord-316626-258rbcwb	56	22	adaptive	adaptive	JJ
cord-316626-258rbcwb	56	23	clinical	clinical	JJ
cord-316626-258rbcwb	56	24	trials	trial	NNS
cord-316626-258rbcwb	56	25	for	for	IN
cord-316626-258rbcwb	56	26	anti	anti	JJ
cord-316626-258rbcwb	56	27	-	-	JJ
cord-316626-258rbcwb	56	28	infective	infective	JJ
cord-316626-258rbcwb	56	29	therapeutics	therapeutic	NNS
cord-316626-258rbcwb	56	30	during	during	IN
cord-316626-258rbcwb	56	31	epidemic	epidemic	NN
cord-316626-258rbcwb	56	32	outbreaks	outbreak	NNS
cord-316626-258rbcwb	57	1	Author	author	NN
cord-316626-258rbcwb	57	2	disclosures	disclosure	NNS
cord-316626-258rbcwb	57	3	are	be	VBP
cord-316626-258rbcwb	57	4	available	available	JJ
cord-316626-258rbcwb	57	5	with	with	IN
cord-316626-258rbcwb	57	6	the	the	DT
cord-316626-258rbcwb	57	7	text	text	NN
cord-316626-258rbcwb	57	8	of	of	IN
cord-316626-258rbcwb	57	9	this	this	DT
cord-316626-258rbcwb	57	10	article	article	NN
cord-316626-258rbcwb	57	11	at	at	IN
cord-316626-258rbcwb	57	12	www.atsjournals.org	www.atsjournals.org	NN
cord-316626-258rbcwb	57	13	.	.	.