id	sid	tid	token	lemma	pos
cord-335198-qp964238	1	1	key	key	JJ
cord-335198-qp964238	1	2	:	:	:
cord-335198-qp964238	1	3	cord-335198-qp964238	cord-335198-qp964238	NNP
cord-335198-qp964238	1	4	authors	author	NNS
cord-335198-qp964238	1	5	:	:	:
cord-335198-qp964238	1	6	Kotsimbos	Kotsimbos	NNP
cord-335198-qp964238	1	7	,	,	,
cord-335198-qp964238	1	8	T.	t.	NN
cord-335198-qp964238	1	9	;	;	:
cord-335198-qp964238	1	10	Humbert	Humbert	NNP
cord-335198-qp964238	1	11	,	,	,
cord-335198-qp964238	1	12	M.	M.	NNP
cord-335198-qp964238	1	13	title	title	NN
cord-335198-qp964238	1	14	:	:	:
cord-335198-qp964238	1	15	Pandemic	Pandemic	NNP
cord-335198-qp964238	1	16	Treatments	Treatments	NNP
cord-335198-qp964238	1	17	on	on	IN
cord-335198-qp964238	1	18	Trial	trial	NN
cord-335198-qp964238	1	19	:	:	:
cord-335198-qp964238	2	1	The	the	DT
cord-335198-qp964238	2	2	bigger	big	JJR
cord-335198-qp964238	2	3	picture	picture	NN
cord-335198-qp964238	2	4	date	date	NN
cord-335198-qp964238	2	5	:	:	:
cord-335198-qp964238	2	6	2020	2020	CD
cord-335198-qp964238	2	7	-	-	HYPH
cord-335198-qp964238	2	8	08	08	CD
cord-335198-qp964238	2	9	-	-	HYPH
cord-335198-qp964238	2	10	03	03	CD
cord-335198-qp964238	2	11	journal	journal	NN
cord-335198-qp964238	2	12	:	:	:
cord-335198-qp964238	3	1	Eur	Eur	NNP
cord-335198-qp964238	3	2	Respir	Respir	NNP
cord-335198-qp964238	3	3	J	J	NNP
cord-335198-qp964238	3	4	DOI	DOI	NNP
cord-335198-qp964238	3	5	:	:	:
cord-335198-qp964238	4	1	10.1183/13993003.02281	10.1183/13993003.02281	CD
cord-335198-qp964238	4	2	-	-	SYM
cord-335198-qp964238	4	3	2020	2020	CD
cord-335198-qp964238	5	1	sha	sha	NNP
cord-335198-qp964238	5	2	:	:	:
cord-335198-qp964238	6	1	e0cf98a657713104ae23249d55752070787cc092	e0cf98a657713104ae23249d55752070787cc092	NNP
cord-335198-qp964238	6	2	doc_id	doc_id	CD
cord-335198-qp964238	6	3	:	:	:
cord-335198-qp964238	6	4	335198	335198	CD
cord-335198-qp964238	6	5	cord_uid	cord_uid	NNS
cord-335198-qp964238	6	6	:	:	:
cord-335198-qp964238	6	7	qp964238	qp964238	ADD
cord-335198-qp964238	7	1	The	the	DT
cord-335198-qp964238	7	2	tension	tension	NN
cord-335198-qp964238	7	3	between	between	IN
cord-335198-qp964238	7	4	immediately	immediately	RB
cord-335198-qp964238	7	5	using	use	VBG
cord-335198-qp964238	7	6	any	any	DT
cord-335198-qp964238	7	7	potentially	potentially	RB
cord-335198-qp964238	7	8	useful	useful	JJ
cord-335198-qp964238	7	9	novel	novel	JJ
cord-335198-qp964238	7	10	therapy	therapy	NN
cord-335198-qp964238	7	11	in	in	IN
cord-335198-qp964238	7	12	COVID19	COVID19	NNP
cord-335198-qp964238	7	13	and	and	CC
cord-335198-qp964238	7	14	trialling	trialle	VBG
cord-335198-qp964238	7	15	all	all	DT
cord-335198-qp964238	7	16	novel	novel	JJ
cord-335198-qp964238	7	17	therapies	therapy	NNS
cord-335198-qp964238	7	18	as	as	RB
cord-335198-qp964238	7	19	rigorously	rigorously	RB
cord-335198-qp964238	7	20	as	as	IN
cord-335198-qp964238	7	21	possible	possible	JJ
cord-335198-qp964238	7	22	is	be	VBZ
cord-335198-qp964238	7	23	addressed	address	VBN
cord-335198-qp964238	7	24	from	from	IN
cord-335198-qp964238	7	25	a	a	DT
cord-335198-qp964238	7	26	bigger	big	JJR
cord-335198-qp964238	7	27	picture	picture	NN
cord-335198-qp964238	7	28	perspective	perspective	NN
cord-335198-qp964238	7	29	.	.	.
cord-335198-qp964238	8	1	Given	give	VBN
cord-335198-qp964238	8	2	the	the	DT
cord-335198-qp964238	8	3	stated	state	VBN
cord-335198-qp964238	8	4	extremes	extreme	NNS
cord-335198-qp964238	8	5	above	above	RB
cord-335198-qp964238	8	6	,	,	,
cord-335198-qp964238	8	7	there	there	EX
cord-335198-qp964238	8	8	is	be	VBZ
cord-335198-qp964238	8	9	a	a	DT
cord-335198-qp964238	8	10	clear	clear	JJ
cord-335198-qp964238	8	11	trade	trade	NN
cord-335198-qp964238	8	12	-	-	HYPH
cord-335198-qp964238	8	13	off	off	NN
cord-335198-qp964238	8	14	between	between	IN
cord-335198-qp964238	8	15	"	"	``
cord-335198-qp964238	8	16	doing	do	VBG
cord-335198-qp964238	8	17	all	all	PDT
cord-335198-qp964238	8	18	that	that	DT
cord-335198-qp964238	8	19	one	one	PRP
cord-335198-qp964238	8	20	can	can	MD
cord-335198-qp964238	8	21	for	for	IN
cord-335198-qp964238	8	22	individual	individual	JJ
cord-335198-qp964238	8	23	patients	patient	NNS
cord-335198-qp964238	8	24	with	with	IN
cord-335198-qp964238	8	25	currently	currently	RB
cord-335198-qp964238	8	26	available	available	JJ
cord-335198-qp964238	8	27	information	information	NN
cord-335198-qp964238	8	28	in	in	IN
cord-335198-qp964238	8	29	a	a	DT
cord-335198-qp964238	8	30	timely	timely	JJ
cord-335198-qp964238	8	31	manner	manner	NN
cord-335198-qp964238	8	32	and	and	CC
cord-335198-qp964238	8	33	despite	despite	IN
cord-335198-qp964238	8	34	significant	significant	JJ
cord-335198-qp964238	8	35	uncertainty	uncertainty	NN
cord-335198-qp964238	8	36	"	"	''
cord-335198-qp964238	8	37	and	and	CC
cord-335198-qp964238	8	38	"	"	``
cord-335198-qp964238	8	39	group	group	NN
cord-335198-qp964238	8	40	treatment	treatment	NN
cord-335198-qp964238	8	41	of	of	IN
cord-335198-qp964238	8	42	individuals	individual	NNS
cord-335198-qp964238	8	43	to	to	TO
cord-335198-qp964238	8	44	be	be	VB
cord-335198-qp964238	8	45	enrolled	enrol	VBN
cord-335198-qp964238	8	46	in	in	IN
cord-335198-qp964238	8	47	properly	properly	RB
cord-335198-qp964238	8	48	conducted	conduct	VBN
cord-335198-qp964238	8	49	but	but	CC
cord-335198-qp964238	8	50	costly	costly	JJ
cord-335198-qp964238	8	51	(	(	-LRB-
cord-335198-qp964238	8	52	effort	effort	NN
cord-335198-qp964238	8	53	,	,	,
cord-335198-qp964238	8	54	time	time	NN
cord-335198-qp964238	8	55	and	and	CC
cord-335198-qp964238	8	56	money	money	NN
cord-335198-qp964238	8	57	)	)	-RRB-
cord-335198-qp964238	8	58	clinical	clinical	JJ
cord-335198-qp964238	8	59	trials	trial	NNS
cord-335198-qp964238	8	60	for	for	IN
cord-335198-qp964238	8	61	specific	specific	JJ
cord-335198-qp964238	8	62	therapeutic	therapeutic	JJ
cord-335198-qp964238	8	63	approaches	approach	NNS
cord-335198-qp964238	8	64	that	that	WDT
cord-335198-qp964238	8	65	will	will	MD
cord-335198-qp964238	8	66	help	help	VB
cord-335198-qp964238	8	67	inform	inform	VB
cord-335198-qp964238	8	68	the	the	DT
cord-335198-qp964238	8	69	evidence	evidence	NN
cord-335198-qp964238	8	70	-	-	HYPH
cord-335198-qp964238	8	71	base	base	NN
cord-335198-qp964238	8	72	for	for	IN
cord-335198-qp964238	8	73	future	future	JJ
cord-335198-qp964238	8	74	patients	patient	NNS
cord-335198-qp964238	8	75	"	"	''
cord-335198-qp964238	8	76	.	.	.
cord-335198-qp964238	9	1	In	in	IN
cord-335198-qp964238	9	2	many	many	JJ
cord-335198-qp964238	9	3	ways	way	NNS
cord-335198-qp964238	9	4	this	this	DT
cord-335198-qp964238	9	5	is	be	VBZ
cord-335198-qp964238	9	6	a	a	DT
cord-335198-qp964238	9	7	false	false	JJ
cord-335198-qp964238	9	8	dichotomy	dichotomy	NN
cord-335198-qp964238	9	9	as	as	IN
cord-335198-qp964238	9	10	both	both	DT
cord-335198-qp964238	9	11	are	be	VBP
cord-335198-qp964238	9	12	necessary	necessary	JJ
cord-335198-qp964238	9	13	frameworks	framework	NNS
cord-335198-qp964238	9	14	with	with	IN
cord-335198-qp964238	9	15	clearly	clearly	RB
cord-335198-qp964238	9	16	defined	define	VBN
cord-335198-qp964238	9	17	validity	validity	NN
cord-335198-qp964238	9	18	and	and	CC
cord-335198-qp964238	9	19	purpose	purpose	NN
cord-335198-qp964238	9	20	,	,	,
cord-335198-qp964238	9	21	which	which	WDT
cord-335198-qp964238	9	22	should	should	MD
cord-335198-qp964238	9	23	ideally	ideally	RB
cord-335198-qp964238	9	24	sit	sit	VB
cord-335198-qp964238	9	25	comfortably	comfortably	RB
cord-335198-qp964238	9	26	next	next	RB
cord-335198-qp964238	9	27	to	to	IN
cord-335198-qp964238	9	28	each	each	DT
cord-335198-qp964238	9	29	other	other	JJ
cord-335198-qp964238	9	30	.	.	.
cord-335198-qp964238	10	1	The	the	DT
cord-335198-qp964238	10	2	lack	lack	NN
cord-335198-qp964238	10	3	of	of	IN
cord-335198-qp964238	10	4	a	a	DT
cord-335198-qp964238	10	5	clear	clear	JJ
cord-335198-qp964238	10	6	transition	transition	NN
cord-335198-qp964238	10	7	zone	zone	NN
cord-335198-qp964238	10	8	between	between	IN
cord-335198-qp964238	10	9	these	these	DT
cord-335198-qp964238	10	10	two	two	CD
cord-335198-qp964238	10	11	frames	frame	NNS
cord-335198-qp964238	10	12	of	of	IN
cord-335198-qp964238	10	13	reference	reference	NN
cord-335198-qp964238	10	14	necessitates	necessitate	VBZ
cord-335198-qp964238	10	15	ambidextrous	ambidextrous	JJ
cord-335198-qp964238	10	16	frame	frame	NN
cord-335198-qp964238	10	17	-	-	HYPH
cord-335198-qp964238	10	18	shifts	shift	NNS
cord-335198-qp964238	10	19	.	.	.
cord-335198-qp964238	11	1	Ideally	ideally	RB
cord-335198-qp964238	11	2	,	,	,
cord-335198-qp964238	11	3	frame	frame	NN
cord-335198-qp964238	11	4	-	-	HYPH
cord-335198-qp964238	11	5	shifting	shifting	NN
cord-335198-qp964238	11	6	would	would	MD
cord-335198-qp964238	11	7	be	be	VB
cord-335198-qp964238	11	8	sensitive	sensitive	JJ
cord-335198-qp964238	11	9	and	and	CC
cord-335198-qp964238	11	10	responsive	responsive	JJ
cord-335198-qp964238	11	11	to	to	IN
cord-335198-qp964238	11	12	the	the	DT
cord-335198-qp964238	11	13	prevailing	prevail	VBG
cord-335198-qp964238	11	14	environment	environment	NN
cord-335198-qp964238	11	15	when	when	WRB
cord-335198-qp964238	11	16	health	health	NN
cord-335198-qp964238	11	17	-	-	HYPH
cord-335198-qp964238	11	18	care	care	NN
cord-335198-qp964238	11	19	provision	provision	NN
cord-335198-qp964238	11	20	is	be	VBZ
cord-335198-qp964238	11	21	at	at	IN
cord-335198-qp964238	11	22	its	-PRON-	PRP$
cord-335198-qp964238	11	23	best	good	JJS
cord-335198-qp964238	11	24	for	for	IN
cord-335198-qp964238	11	25	any	any	DT
cord-335198-qp964238	11	26	level	level	NN
cord-335198-qp964238	11	27	of	of	IN
cord-335198-qp964238	11	28	resource	resource	NN
cord-335198-qp964238	11	29	constraint	constraint	NN
cord-335198-qp964238	11	30	.	.	.
cord-335198-qp964238	12	1	Although	although	IN
cord-335198-qp964238	12	2	this	this	DT
cord-335198-qp964238	12	3	may	may	MD
cord-335198-qp964238	12	4	be	be	VB
cord-335198-qp964238	12	5	difficult	difficult	JJ
cord-335198-qp964238	12	6	to	to	TO
cord-335198-qp964238	12	7	define	define	VB
cord-335198-qp964238	12	8	in	in	IN
cord-335198-qp964238	12	9	positive	positive	JJ
cord-335198-qp964238	12	10	terms	term	NNS
cord-335198-qp964238	12	11	of	of	IN
cord-335198-qp964238	12	12	agility	agility	NN
cord-335198-qp964238	12	13	,	,	,
cord-335198-qp964238	12	14	dynamic	dynamic	JJ
cord-335198-qp964238	12	15	range	range	NN
cord-335198-qp964238	12	16	and	and	CC
cord-335198-qp964238	12	17	contextual	contextual	JJ
cord-335198-qp964238	12	18	fit	fit	NN
cord-335198-qp964238	12	19	across	across	IN
cord-335198-qp964238	12	20	and	and	CC
cord-335198-qp964238	12	21	within	within	IN
cord-335198-qp964238	12	22	multiple	multiple	JJ
cord-335198-qp964238	12	23	frames	frame	NNS
cord-335198-qp964238	12	24	,	,	,
cord-335198-qp964238	12	25	it	-PRON-	PRP
cord-335198-qp964238	12	26	is	be	VBZ
cord-335198-qp964238	12	27	most	most	RBS
cord-335198-qp964238	12	28	easily	easily	RB
cord-335198-qp964238	12	29	identifiable	identifiable	JJ
cord-335198-qp964238	12	30	by	by	IN
cord-335198-qp964238	12	31	its	-PRON-	PRP$
cord-335198-qp964238	12	32	absence	absence	NN
cord-335198-qp964238	12	33	.	.	.
cord-335198-qp964238	13	1	This	this	DT
cord-335198-qp964238	13	2	absence	absence	NN
cord-335198-qp964238	13	3	is	be	VBZ
cord-335198-qp964238	13	4	even	even	RB
cord-335198-qp964238	13	5	more	more	RBR
cord-335198-qp964238	13	6	obvious	obvious	JJ
cord-335198-qp964238	13	7	when	when	WRB
cord-335198-qp964238	13	8	the	the	DT
cord-335198-qp964238	13	9	"	"	``
cord-335198-qp964238	13	10	in	in	IN
cord-335198-qp964238	13	11	-	-	HYPH
cord-335198-qp964238	13	12	between	between	IN
cord-335198-qp964238	13	13	"	"	``
cord-335198-qp964238	13	14	situation	situation	NN
cord-335198-qp964238	13	15	is	be	VBZ
cord-335198-qp964238	13	16	excessively	excessively	RB
cord-335198-qp964238	13	17	encroached	encroach	VBN
cord-335198-qp964238	13	18	upon	upon	IN
cord-335198-qp964238	13	19	as	as	IN
cord-335198-qp964238	13	20	some	some	DT
cord-335198-qp964238	13	21	sort	sort	NN
cord-335198-qp964238	13	22	of	of	IN
cord-335198-qp964238	13	23	compensatory	compensatory	JJ
cord-335198-qp964238	13	24	way	way	NN
cord-335198-qp964238	13	25	forward	forward	RB
cord-335198-qp964238	13	26	.	.	.
cord-335198-qp964238	14	1	Here	here	RB
cord-335198-qp964238	14	2	,	,	,
cord-335198-qp964238	14	3	therapies	therapy	NNS
cord-335198-qp964238	14	4	are	be	VBP
cord-335198-qp964238	14	5	prescribed	prescribe	VBN
cord-335198-qp964238	14	6	to	to	IN
cord-335198-qp964238	14	7	patients	patient	NNS
cord-335198-qp964238	14	8	for	for	IN
cord-335198-qp964238	14	9	varying	vary	VBG
cord-335198-qp964238	14	10	reasons	reason	NNS
cord-335198-qp964238	14	11	that	that	WDT
cord-335198-qp964238	14	12	can	can	MD
cord-335198-qp964238	14	13	only	only	RB
cord-335198-qp964238	14	14	be	be	VB
cord-335198-qp964238	14	15	partly	partly	RB
cord-335198-qp964238	14	16	rationalized	rationalize	VBN
cord-335198-qp964238	14	17	on	on	IN
cord-335198-qp964238	14	18	the	the	DT
cord-335198-qp964238	14	19	basis	basis	NN
cord-335198-qp964238	14	20	of	of	IN
cord-335198-qp964238	14	21	either	either	DT
cord-335198-qp964238	14	22	individual	individual	JJ
cord-335198-qp964238	14	23	or	or	CC
cord-335198-qp964238	14	24	group	group	NN
cord-335198-qp964238	14	25	interests	interest	NNS
cord-335198-qp964238	14	26	.	.	.
cord-335198-qp964238	15	1	The	the	DT
cord-335198-qp964238	15	2	resultant	resultant	JJ
cord-335198-qp964238	15	3	case	case	NN
cord-335198-qp964238	15	4	series	series	NN
cord-335198-qp964238	15	5	and	and	CC
cord-335198-qp964238	15	6	uncontrolled	uncontrolled	JJ
cord-335198-qp964238	15	7	observational	observational	JJ
cord-335198-qp964238	15	8	studies	study	NNS
cord-335198-qp964238	15	9	therefore	therefore	RB
cord-335198-qp964238	15	10	quickly	quickly	RB
cord-335198-qp964238	15	11	transition	transition	VBP
cord-335198-qp964238	15	12	from	from	IN
cord-335198-qp964238	15	13	a	a	DT
cord-335198-qp964238	15	14	reasonable	reasonable	JJ
cord-335198-qp964238	15	15	,	,	,
cord-335198-qp964238	15	16	adaptive	adaptive	JJ
cord-335198-qp964238	15	17	initial	initial	JJ
cord-335198-qp964238	15	18	response	response	NN
cord-335198-qp964238	15	19	to	to	TO
cord-335198-qp964238	15	20	explore	explore	VB
cord-335198-qp964238	15	21	large	large	JJ
cord-335198-qp964238	15	22	efficacy	efficacy	NN
cord-335198-qp964238	15	23	and	and	CC
cord-335198-qp964238	15	24	safety	safety	NN
cord-335198-qp964238	15	25	signals	signal	NNS
cord-335198-qp964238	15	26	in	in	IN
cord-335198-qp964238	15	27	poor	poor	JJ
cord-335198-qp964238	15	28	clinical	clinical	JJ
cord-335198-qp964238	15	29	outcome	outcome	NN
cord-335198-qp964238	15	30	settings	setting	NNS
cord-335198-qp964238	15	31	to	to	IN
cord-335198-qp964238	15	32	efforts	effort	NNS
cord-335198-qp964238	15	33	that	that	WDT
cord-335198-qp964238	15	34	are	be	VBP
cord-335198-qp964238	15	35	maladaptive	maladaptive	JJ
cord-335198-qp964238	15	36	when	when	WRB
cord-335198-qp964238	15	37	excessive	excessive	JJ
cord-335198-qp964238	15	38	.	.	.
cord-335198-qp964238	16	1	At	at	IN
cord-335198-qp964238	16	2	best	well	RBS
cord-335198-qp964238	16	3	,	,	,
cord-335198-qp964238	16	4	these	these	DT
cord-335198-qp964238	16	5	efforts	effort	NNS
cord-335198-qp964238	16	6	minimally	minimally	RB
cord-335198-qp964238	16	7	progress	progress	VBP
cord-335198-qp964238	16	8	either	either	CC
cord-335198-qp964238	16	9	individual	individual	JJ
cord-335198-qp964238	16	10	patient	patient	NN
cord-335198-qp964238	16	11	care	care	NN
cord-335198-qp964238	16	12	decisions	decision	NNS
cord-335198-qp964238	16	13	or	or	CC
cord-335198-qp964238	16	14	the	the	DT
cord-335198-qp964238	16	15	broader	broad	JJR
cord-335198-qp964238	16	16	evidence	evidence	NN
cord-335198-qp964238	16	17	-	-	HYPH
cord-335198-qp964238	16	18	base	base	NN
cord-335198-qp964238	16	19	necessary	necessary	JJ
cord-335198-qp964238	16	20	to	to	TO
cord-335198-qp964238	16	21	inform	inform	VB
cord-335198-qp964238	16	22	integrating	integrate	VBG
cord-335198-qp964238	16	23	guidelines	guideline	NNS
cord-335198-qp964238	16	24	.	.	.
cord-335198-qp964238	17	1	At	at	RB
cord-335198-qp964238	17	2	worst	worst	RBS
cord-335198-qp964238	17	3	,	,	,
cord-335198-qp964238	17	4	unchecked	unchecked	JJ
cord-335198-qp964238	17	5	biases	bias	NNS
cord-335198-qp964238	17	6	may	may	MD
cord-335198-qp964238	17	7	lead	lead	VB
cord-335198-qp964238	17	8	to	to	IN
cord-335198-qp964238	17	9	false	false	JJ
cord-335198-qp964238	17	10	positive	positive	JJ
cord-335198-qp964238	17	11	results	result	NNS
cord-335198-qp964238	17	12	whilst	whilst	IN
cord-335198-qp964238	17	13	simultaneously	simultaneously	RB
cord-335198-qp964238	17	14	diverting	divert	VBG
cord-335198-qp964238	17	15	resources	resource	NNS
cord-335198-qp964238	17	16	from	from	IN
cord-335198-qp964238	17	17	potentially	potentially	RB
cord-335198-qp964238	17	18	more	more	RBR
cord-335198-qp964238	17	19	useful	useful	JJ
cord-335198-qp964238	17	20	strategies	strategy	NNS
cord-335198-qp964238	17	21	.	.	.
cord-335198-qp964238	18	1	That	that	IN
cord-335198-qp964238	18	2	there	there	EX
cord-335198-qp964238	18	3	has	have	VBZ
cord-335198-qp964238	18	4	been	be	VBN
cord-335198-qp964238	18	5	an	an	DT
cord-335198-qp964238	18	6	excess	excess	NN
cord-335198-qp964238	18	7	of	of	IN
cord-335198-qp964238	18	8	small	small	JJ
cord-335198-qp964238	18	9	and	and	CC
cord-335198-qp964238	18	10	uncontrolled	uncontrolled	JJ
cord-335198-qp964238	18	11	trials	trial	NNS
cord-335198-qp964238	18	12	in	in	IN
cord-335198-qp964238	18	13	the	the	DT
cord-335198-qp964238	18	14	setting	setting	NN
cord-335198-qp964238	18	15	of	of	IN
cord-335198-qp964238	18	16	a	a	DT
cord-335198-qp964238	18	17	COVID19	COVID19	NNP
cord-335198-qp964238	18	18	pandemic	pandemic	NN
cord-335198-qp964238	18	19	which	which	WDT
cord-335198-qp964238	18	20	itself	-PRON-	PRP
cord-335198-qp964238	18	21	is	be	VBZ
cord-335198-qp964238	18	22	very	very	RB
cord-335198-qp964238	18	23	much	much	RB
cord-335198-qp964238	18	24	an	an	DT
cord-335198-qp964238	18	25	"	"	``
cord-335198-qp964238	18	26	n	n	NN
cord-335198-qp964238	18	27	of	of	IN
cord-335198-qp964238	18	28	1	1	CD
cord-335198-qp964238	18	29	"	"	''
cord-335198-qp964238	18	30	situation	situation	NN
cord-335198-qp964238	18	31	is	be	VBZ
cord-335198-qp964238	18	32	therefore	therefore	RB
cord-335198-qp964238	18	33	worthy	worthy	JJ
cord-335198-qp964238	18	34	of	of	IN
cord-335198-qp964238	18	35	further	further	JJ
cord-335198-qp964238	18	36	reflection	reflection	NN
cord-335198-qp964238	18	37	and	and	CC
cord-335198-qp964238	18	38	exploration	exploration	NN
cord-335198-qp964238	18	39	.	.	.
cord-335198-qp964238	19	1	Whose	whose	WP$
cord-335198-qp964238	19	2	needs	need	NNS
cord-335198-qp964238	19	3	are	be	VBP
cord-335198-qp964238	19	4	being	be	VBG
cord-335198-qp964238	19	5	met	meet	VBN
cord-335198-qp964238	19	6	?	?	.
cord-335198-qp964238	20	1	How	how	WRB
cord-335198-qp964238	20	2	do	do	VBP
cord-335198-qp964238	20	3	we	-PRON-	PRP
cord-335198-qp964238	20	4	best	well	RBS
cord-335198-qp964238	20	5	explore	explore	VB
cord-335198-qp964238	20	6	and	and	CC
cord-335198-qp964238	20	7	exploit	exploit	VB
cord-335198-qp964238	20	8	our	-PRON-	PRP$
cord-335198-qp964238	20	9	overall	overall	JJ
cord-335198-qp964238	20	10	clinical	clinical	JJ
cord-335198-qp964238	20	11	management	management	NN
cord-335198-qp964238	20	12	and	and	CC
cord-335198-qp964238	20	13	scientific	scientific	JJ
cord-335198-qp964238	20	14	research	research	NN
cord-335198-qp964238	20	15	approach	approach	NN
cord-335198-qp964238	20	16	during	during	IN
cord-335198-qp964238	20	17	the	the	DT
cord-335198-qp964238	20	18	COVID19	COVID19	NNP
cord-335198-qp964238	20	19	pandemic	pandemic	NN
cord-335198-qp964238	20	20	?	?	.
cord-335198-qp964238	21	1	There	there	EX
cord-335198-qp964238	21	2	is	be	VBZ
cord-335198-qp964238	21	3	little	little	JJ
cord-335198-qp964238	21	4	argument	argument	NN
cord-335198-qp964238	21	5	with	with	IN
cord-335198-qp964238	21	6	the	the	DT
cord-335198-qp964238	21	7	upholding	uphold	VBG
cord-335198-qp964238	21	8	the	the	DT
cord-335198-qp964238	21	9	public	public	JJ
cord-335198-qp964238	21	10	health	health	NN
cord-335198-qp964238	21	11	principles	principle	NNS
cord-335198-qp964238	21	12	and	and	CC
cord-335198-qp964238	21	13	standards	standard	NNS
cord-335198-qp964238	21	14	of	of	IN
cord-335198-qp964238	21	15	supportive	supportive	JJ
cord-335198-qp964238	21	16	care	care	NN
cord-335198-qp964238	21	17	in	in	IN
cord-335198-qp964238	21	18	relatively	relatively	RB
cord-335198-qp964238	21	19	mild	mild	JJ
cord-335198-qp964238	21	20	community	community	NN
cord-335198-qp964238	21	21	cases	case	NNS
cord-335198-qp964238	21	22	that	that	WDT
cord-335198-qp964238	21	23	are	be	VBP
cord-335198-qp964238	21	24	likely	likely	JJ
cord-335198-qp964238	21	25	to	to	TO
cord-335198-qp964238	21	26	recover	recover	VB
cord-335198-qp964238	21	27	without	without	IN
cord-335198-qp964238	21	28	ill	ill	JJ
cord-335198-qp964238	21	29	effect	effect	NN
cord-335198-qp964238	21	30	.	.	.
cord-335198-qp964238	22	1	But	but	CC
cord-335198-qp964238	22	2	how	how	WRB
cord-335198-qp964238	22	3	do	do	VBP
cord-335198-qp964238	22	4	we	-PRON-	PRP
cord-335198-qp964238	22	5	minimize	minimize	VB
cord-335198-qp964238	22	6	the	the	DT
cord-335198-qp964238	22	7	risks	risk	NNS
cord-335198-qp964238	22	8	of	of	IN
cord-335198-qp964238	22	9	progression	progression	NN
cord-335198-qp964238	22	10	in	in	IN
cord-335198-qp964238	22	11	more	more	RBR
cord-335198-qp964238	22	12	severe	severe	JJ
cord-335198-qp964238	22	13	hospitalized	hospitalize	VBN
cord-335198-qp964238	22	14	cases	case	NNS
cord-335198-qp964238	22	15	,	,	,
cord-335198-qp964238	22	16	particularly	particularly	RB
cord-335198-qp964238	22	17	older	old	JJR
cord-335198-qp964238	22	18	patients	patient	NNS
cord-335198-qp964238	22	19	with	with	IN
cord-335198-qp964238	22	20	risk	risk	NN
cord-335198-qp964238	22	21	factor	factor	NN
cord-335198-qp964238	22	22	co	co	NNS
cord-335198-qp964238	22	23	-	-	NNS
cord-335198-qp964238	22	24	morbidities	morbidity	NNS
cord-335198-qp964238	22	25	?	?	.
cord-335198-qp964238	23	1	How	how	WRB
cord-335198-qp964238	23	2	do	do	VBP
cord-335198-qp964238	23	3	we	-PRON-	PRP
cord-335198-qp964238	23	4	maximize	maximize	VB
cord-335198-qp964238	23	5	compassionate	compassionate	JJ
cord-335198-qp964238	23	6	use	use	NN
cord-335198-qp964238	23	7	of	of	IN
cord-335198-qp964238	23	8	available	available	JJ
cord-335198-qp964238	23	9	,	,	,
cord-335198-qp964238	23	10	potentially	potentially	RB
cord-335198-qp964238	23	11	useful	useful	JJ
cord-335198-qp964238	23	12	but	but	CC
cord-335198-qp964238	23	13	unproven	unproven	JJ
cord-335198-qp964238	23	14	therapies	therapy	NNS
cord-335198-qp964238	23	15	when	when	WRB
cord-335198-qp964238	23	16	no	no	DT
cord-335198-qp964238	23	17	other	other	JJ
cord-335198-qp964238	23	18	alternatives	alternative	NNS
cord-335198-qp964238	23	19	exist	exist	VBP
cord-335198-qp964238	23	20	?	?	.
cord-335198-qp964238	24	1	How	how	WRB
cord-335198-qp964238	24	2	do	do	VBP
cord-335198-qp964238	24	3	we	-PRON-	PRP
cord-335198-qp964238	24	4	minimize	minimize	VB
cord-335198-qp964238	24	5	the	the	DT
cord-335198-qp964238	24	6	risks	risk	NNS
cord-335198-qp964238	24	7	of	of	IN
cord-335198-qp964238	24	8	these	these	DT
cord-335198-qp964238	24	9	very	very	RB
cord-335198-qp964238	24	10	same	same	JJ
cord-335198-qp964238	24	11	therapies	therapy	NNS
cord-335198-qp964238	24	12	for	for	IN
cord-335198-qp964238	24	13	individual	individual	JJ
cord-335198-qp964238	24	14	patients	patient	NNS
cord-335198-qp964238	24	15	?	?	.
cord-335198-qp964238	25	1	And	and	CC
cord-335198-qp964238	25	2	how	how	WRB
cord-335198-qp964238	25	3	do	do	VBP
cord-335198-qp964238	25	4	we	-PRON-	PRP
cord-335198-qp964238	25	5	quickly	quickly	RB
cord-335198-qp964238	25	6	establish	establish	VB
cord-335198-qp964238	25	7	and	and	CC
cord-335198-qp964238	25	8	conduct	conduct	VB
cord-335198-qp964238	25	9	difficult	difficult	JJ
cord-335198-qp964238	25	10	and	and	CC
cord-335198-qp964238	25	11	costly	costly	JJ
cord-335198-qp964238	25	12	randomized	randomized	JJ
cord-335198-qp964238	25	13	,	,	,
cord-335198-qp964238	25	14	controlled	control	VBN
cord-335198-qp964238	25	15	clinical	clinical	JJ
cord-335198-qp964238	25	16	trials	trial	NNS
cord-335198-qp964238	25	17	for	for	IN
cord-335198-qp964238	25	18	the	the	DT
cord-335198-qp964238	25	19	most	most	RBS
cord-335198-qp964238	25	20	promising	promising	JJ
cord-335198-qp964238	25	21	old	old	JJ
cord-335198-qp964238	25	22	and	and	CC
cord-335198-qp964238	25	23	new	new	JJ
cord-335198-qp964238	25	24	therapies	therapy	NNS
cord-335198-qp964238	25	25	where	where	WRB
cord-335198-qp964238	25	26	there	there	EX
cord-335198-qp964238	25	27	is	be	VBZ
cord-335198-qp964238	25	28	a	a	DT
cord-335198-qp964238	25	29	clear	clear	JJ
cord-335198-qp964238	25	30	equipoise	equipoise	NN
cord-335198-qp964238	25	31	between	between	IN
cord-335198-qp964238	25	32	possible	possible	JJ
cord-335198-qp964238	25	33	benefits	benefit	NNS
cord-335198-qp964238	25	34	and	and	CC
cord-335198-qp964238	25	35	potential	potential	JJ
cord-335198-qp964238	25	36	risks	risk	NNS
cord-335198-qp964238	25	37	?	?	.
cord-335198-qp964238	26	1	All	all	PDT
cord-335198-qp964238	26	2	these	these	DT
cord-335198-qp964238	26	3	questions	question	NNS
cord-335198-qp964238	26	4	so	so	RB
cord-335198-qp964238	26	5	far	far	RB
cord-335198-qp964238	26	6	turn	turn	VBP
cord-335198-qp964238	26	7	on	on	RP
cord-335198-qp964238	26	8	what	what	WP
cord-335198-qp964238	26	9	is	be	VBZ
cord-335198-qp964238	26	10	hopefully	hopefully	RB
cord-335198-qp964238	26	11	an	an	DT
cord-335198-qp964238	26	12	impartial	impartial	JJ
cord-335198-qp964238	26	13	assessment	assessment	NN
cord-335198-qp964238	26	14	of	of	IN
cord-335198-qp964238	26	15	what	what	WP
cord-335198-qp964238	26	16	is	be	VBZ
cord-335198-qp964238	26	17	in	in	IN
cord-335198-qp964238	26	18	the	the	DT
cord-335198-qp964238	26	19	best	good	JJS
cord-335198-qp964238	26	20	interests	interest	NNS
cord-335198-qp964238	26	21	of	of	IN
cord-335198-qp964238	26	22	the	the	DT
cord-335198-qp964238	26	23	patient	patient	NN
cord-335198-qp964238	26	24	.	.	.
cord-335198-qp964238	27	1	However	however	RB
cord-335198-qp964238	27	2	,	,	,
cord-335198-qp964238	27	3	there	there	EX
cord-335198-qp964238	27	4	are	be	VBP
cord-335198-qp964238	27	5	also	also	RB
cord-335198-qp964238	27	6	other	other	JJ
cord-335198-qp964238	27	7	potential	potential	JJ
cord-335198-qp964238	27	8	factors	factor	NNS
cord-335198-qp964238	27	9	at	at	IN
cord-335198-qp964238	27	10	play	play	NN
cord-335198-qp964238	27	11	,	,	,
cord-335198-qp964238	27	12	albeit	albeit	IN
cord-335198-qp964238	27	13	very	very	RB
cord-335198-qp964238	27	14	difficult	difficult	JJ
cord-335198-qp964238	27	15	to	to	TO
cord-335198-qp964238	27	16	quantify	quantify	VB
cord-335198-qp964238	27	17	.	.	.
cord-335198-qp964238	28	1	These	these	DT
cord-335198-qp964238	28	2	include	include	VBP
cord-335198-qp964238	28	3	(	(	-LRB-
cord-335198-qp964238	28	4	in	in	IN
cord-335198-qp964238	28	5	no	no	DT
cord-335198-qp964238	28	6	specific	specific	JJ
cord-335198-qp964238	28	7	order	order	NN
cord-335198-qp964238	28	8	)	)	-RRB-
cord-335198-qp964238	28	9	:	:	:
cord-335198-qp964238	29	1	i	i	PRP
cord-335198-qp964238	29	2	)	)	-RRB-
cord-335198-qp964238	29	3	the	the	DT
cord-335198-qp964238	29	4	difficult	difficult	JJ
cord-335198-qp964238	29	5	research	research	NN
cord-335198-qp964238	29	6	environment	environment	NN
cord-335198-qp964238	29	7	that	that	WDT
cord-335198-qp964238	29	8	would	would	MD
cord-335198-qp964238	29	9	necessarily	necessarily	RB
cord-335198-qp964238	29	10	follow	follow	VB
cord-335198-qp964238	29	11	from	from	IN
cord-335198-qp964238	29	12	health	health	NN
cord-335198-qp964238	29	13	care	care	NN
cord-335198-qp964238	29	14	systems	system	NNS
cord-335198-qp964238	29	15	that	that	WDT
cord-335198-qp964238	29	16	are	be	VBP
cord-335198-qp964238	29	17	overwhelmed	overwhelmed	JJ
cord-335198-qp964238	29	18	in	in	IN
cord-335198-qp964238	29	19	a	a	DT
cord-335198-qp964238	29	20	pandemic	pandemic	NN
cord-335198-qp964238	29	21	setting	setting	NN
cord-335198-qp964238	29	22	;	;	:
cord-335198-qp964238	29	23	ii	ii	LS
cord-335198-qp964238	29	24	)	)	-RRB-
cord-335198-qp964238	29	25	specific	specific	JJ
cord-335198-qp964238	29	26	resource	resource	NN
cord-335198-qp964238	29	27	and	and	CC
cord-335198-qp964238	29	28	funding	funding	NN
cord-335198-qp964238	29	29	constraints	constraint	NNS
cord-335198-qp964238	29	30	in	in	IN
cord-335198-qp964238	29	31	such	such	JJ
cord-335198-qp964238	29	32	systems	system	NNS
cord-335198-qp964238	29	33	;	;	:
cord-335198-qp964238	29	34	iii	iii	LS
cord-335198-qp964238	29	35	)	)	-RRB-
cord-335198-qp964238	29	36	widespread	widespread	JJ
cord-335198-qp964238	29	37	fear	fear	NN
cord-335198-qp964238	29	38	and	and	CC
cord-335198-qp964238	29	39	anxiety	anxiety	NN
cord-335198-qp964238	29	40	at	at	IN
cord-335198-qp964238	29	41	all	all	DT
cord-335198-qp964238	29	42	levels	level	NNS
cord-335198-qp964238	29	43	of	of	IN
cord-335198-qp964238	29	44	the	the	DT
cord-335198-qp964238	29	45	community	community	NN
cord-335198-qp964238	29	46	including	include	VBG
cord-335198-qp964238	29	47	healthcare	healthcare	NN
cord-335198-qp964238	29	48	providers	provider	NNS
cord-335198-qp964238	29	49	;	;	:
cord-335198-qp964238	29	50	iv	iv	LS
cord-335198-qp964238	29	51	)	)	-RRB-
cord-335198-qp964238	29	52	clinician	clinician	NN
cord-335198-qp964238	29	53	-	-	HYPH
cord-335198-qp964238	29	54	researcher	researcher	NN
cord-335198-qp964238	29	55	and	and	CC
cord-335198-qp964238	29	56	other	other	JJ
cord-335198-qp964238	29	57	interested	interested	JJ
cord-335198-qp964238	29	58	party	party	NN
cord-335198-qp964238	29	59	belief	belief	NN
cord-335198-qp964238	29	60	systems	system	NNS
cord-335198-qp964238	29	61	and	and	CC
cord-335198-qp964238	29	62	potential	potential	JJ
cord-335198-qp964238	29	63	"	"	``
cord-335198-qp964238	29	64	savior	savior	NN
cord-335198-qp964238	29	65	"	"	''
cord-335198-qp964238	29	66	mentalities	mentality	NNS
cord-335198-qp964238	29	67	;	;	:
cord-335198-qp964238	29	68	v	v	LS
cord-335198-qp964238	29	69	)	)	-RRB-
cord-335198-qp964238	29	70	potential	potential	JJ
cord-335198-qp964238	29	71	pharma	pharma	NNS
cord-335198-qp964238	29	72	industry	industry	NN
cord-335198-qp964238	29	73	interests	interest	NNS
cord-335198-qp964238	29	74	regarding	regard	VBG
cord-335198-qp964238	29	75	expanding	expand	VBG
cord-335198-qp964238	29	76	re	re	JJ
cord-335198-qp964238	29	77	-	-	JJ
cord-335198-qp964238	29	78	purposed	purpose	VBN
cord-335198-qp964238	29	79	drug	drug	NN
cord-335198-qp964238	29	80	possibilities	possibility	NNS
cord-335198-qp964238	29	81	;	;	:
cord-335198-qp964238	29	82	vi	vi	NNP
cord-335198-qp964238	29	83	)	)	-RRB-
cord-335198-qp964238	29	84	potential	potential	JJ
cord-335198-qp964238	29	85	biotech	biotech	JJ
cord-335198-qp964238	29	86	start	start	VB
cord-335198-qp964238	29	87	-	-	HYPH
cord-335198-qp964238	29	88	up	up	RP
cord-335198-qp964238	29	89	/	/	SYM
cord-335198-qp964238	29	90	pharma	pharma	NNS
cord-335198-qp964238	29	91	interests	interest	NNS
cord-335198-qp964238	29	92	regarding	regard	VBG
cord-335198-qp964238	29	93	new	new	JJ
cord-335198-qp964238	29	94	agent	agent	NN
cord-335198-qp964238	29	95	fast	fast	JJ
cord-335198-qp964238	29	96	tracking	tracking	NN
cord-335198-qp964238	29	97	opportunities	opportunity	NNS
cord-335198-qp964238	29	98	;	;	:
cord-335198-qp964238	29	99	vii	vii	NN
cord-335198-qp964238	29	100	)	)	-RRB-
cord-335198-qp964238	29	101	potential	potential	JJ
cord-335198-qp964238	29	102	political	political	JJ
cord-335198-qp964238	29	103	and	and	CC
cord-335198-qp964238	29	104	economic	economic	JJ
cord-335198-qp964238	29	105	interests	interest	NNS
cord-335198-qp964238	29	106	;	;	:
cord-335198-qp964238	29	107	and	and	CC
cord-335198-qp964238	29	108	viii	viii	NNP
cord-335198-qp964238	29	109	)	)	-RRB-
cord-335198-qp964238	29	110	potential	potential	JJ
cord-335198-qp964238	29	111	media	medium	NNS
cord-335198-qp964238	29	112	and	and	CC
cord-335198-qp964238	29	113	socio	socio	JJ
cord-335198-qp964238	29	114	-	-	JJ
cord-335198-qp964238	29	115	cultural	cultural	JJ
cord-335198-qp964238	29	116	factors	factor	NNS
cord-335198-qp964238	29	117	.	.	.
cord-335198-qp964238	30	1	Although	although	IN
cord-335198-qp964238	30	2	it	-PRON-	PRP
cord-335198-qp964238	30	3	is	be	VBZ
cord-335198-qp964238	30	4	impossible	impossible	JJ
cord-335198-qp964238	30	5	to	to	TO
cord-335198-qp964238	30	6	quantify	quantify	VB
cord-335198-qp964238	30	7	in	in	IN
cord-335198-qp964238	30	8	any	any	DT
cord-335198-qp964238	30	9	meaningful	meaningful	JJ
cord-335198-qp964238	30	10	way	way	NN
cord-335198-qp964238	30	11	the	the	DT
cord-335198-qp964238	30	12	magnitude	magnitude	NN
cord-335198-qp964238	30	13	of	of	IN
cord-335198-qp964238	30	14	these	these	DT
cord-335198-qp964238	30	15	factors	factor	NNS
cord-335198-qp964238	30	16	and	and	CC
cord-335198-qp964238	30	17	how	how	WRB
cord-335198-qp964238	30	18	they	-PRON-	PRP
cord-335198-qp964238	30	19	may	may	MD
cord-335198-qp964238	30	20	all	all	RB
cord-335198-qp964238	30	21	interact	interact	VB
cord-335198-qp964238	30	22	with	with	IN
cord-335198-qp964238	30	23	each	each	DT
cord-335198-qp964238	30	24	other	other	JJ
cord-335198-qp964238	30	25	,	,	,
cord-335198-qp964238	30	26	an	an	DT
cord-335198-qp964238	30	27	enlightened	enlightened	JJ
cord-335198-qp964238	30	28	awareness	awareness	NN
cord-335198-qp964238	30	29	of	of	IN
cord-335198-qp964238	30	30	all	all	PDT
cord-335198-qp964238	30	31	these	these	DT
cord-335198-qp964238	30	32	possibilities	possibility	NNS
cord-335198-qp964238	30	33	is	be	VBZ
cord-335198-qp964238	30	34	an	an	DT
cord-335198-qp964238	30	35	essential	essential	JJ
cord-335198-qp964238	30	36	first	first	JJ
cord-335198-qp964238	30	37	step	step	NN
cord-335198-qp964238	30	38	to	to	IN
cord-335198-qp964238	30	39	both	both	CC
cord-335198-qp964238	30	40	prevention	prevention	NN
cord-335198-qp964238	30	41	and	and	CC
cord-335198-qp964238	30	42	any	any	DT
cord-335198-qp964238	30	43	countering	counter	VBG
cord-335198-qp964238	30	44	response	response	NN
cord-335198-qp964238	30	45	.	.	.
cord-335198-qp964238	31	1	It	-PRON-	PRP
cord-335198-qp964238	31	2	is	be	VBZ
cord-335198-qp964238	31	3	also	also	RB
cord-335198-qp964238	31	4	the	the	DT
cord-335198-qp964238	31	5	quintessential	quintessential	JJ
cord-335198-qp964238	31	6	function	function	NN
cord-335198-qp964238	31	7	that	that	WDT
cord-335198-qp964238	31	8	underpins	underpin	VBZ
cord-335198-qp964238	31	9	all	all	DT
cord-335198-qp964238	31	10	drug	drug	NN
cord-335198-qp964238	31	11	evaluating	evaluate	VBG
cord-335198-qp964238	31	12	regulatory	regulatory	JJ
cord-335198-qp964238	31	13	agencies	agency	NNS
cord-335198-qp964238	31	14	/	/	SYM
cord-335198-qp964238	31	15	processes	process	NNS
cord-335198-qp964238	31	16	that	that	WDT
cord-335198-qp964238	31	17	we	-PRON-	PRP
cord-335198-qp964238	31	18	discard	discard	VBP
cord-335198-qp964238	31	19	or	or	CC
cord-335198-qp964238	31	20	bypass	bypass	VB
cord-335198-qp964238	31	21	at	at	IN
cord-335198-qp964238	31	22	our	-PRON-	PRP$
cord-335198-qp964238	31	23	peril	peril	NN
cord-335198-qp964238	31	24	.	.	.
cord-335198-qp964238	32	1	In	in	IN
cord-335198-qp964238	32	2	the	the	DT
cord-335198-qp964238	32	3	midst	midst	NN
cord-335198-qp964238	32	4	of	of	IN
cord-335198-qp964238	32	5	a	a	DT
cord-335198-qp964238	32	6	pandemic	pandemic	NN
cord-335198-qp964238	32	7	that	that	WDT
cord-335198-qp964238	32	8	has	have	VBZ
cord-335198-qp964238	32	9	overwhelmed	overwhelm	VBN
cord-335198-qp964238	32	10	many	many	JJ
cord-335198-qp964238	32	11	health	health	NN
cord-335198-qp964238	32	12	-	-	HYPH
cord-335198-qp964238	32	13	care	care	NN
cord-335198-qp964238	32	14	systems	system	NNS
cord-335198-qp964238	32	15	globally	globally	RB
cord-335198-qp964238	32	16	it	-PRON-	PRP
cord-335198-qp964238	32	17	is	be	VBZ
cord-335198-qp964238	32	18	indeed	indeed	RB
cord-335198-qp964238	32	19	very	very	RB
cord-335198-qp964238	32	20	impressive	impressive	JJ
cord-335198-qp964238	32	21	that	that	IN
cord-335198-qp964238	32	22	several	several	JJ
cord-335198-qp964238	32	23	,	,	,
cord-335198-qp964238	32	24	large	large	JJ
cord-335198-qp964238	32	25	collaborative	collaborative	JJ
cord-335198-qp964238	32	26	clinical	clinical	JJ
cord-335198-qp964238	32	27	trials	trial	NNS
cord-335198-qp964238	32	28	have	have	VBP
cord-335198-qp964238	32	29	already	already	RB
cord-335198-qp964238	32	30	been	be	VBN
cord-335198-qp964238	32	31	established	establish	VBN
cord-335198-qp964238	32	32	to	to	TO
cord-335198-qp964238	32	33	meaningfully	meaningfully	RB
cord-335198-qp964238	32	34	assess	assess	VB
cord-335198-qp964238	32	35	potential	potential	JJ
cord-335198-qp964238	32	36	COVID19	covid19	NN
cord-335198-qp964238	32	37	therapies	therapy	NNS
cord-335198-qp964238	32	38	including	include	VBG
cord-335198-qp964238	32	39	the	the	DT
cord-335198-qp964238	32	40	World	World	NNP
cord-335198-qp964238	32	41	Health	Health	NNP
cord-335198-qp964238	32	42	Organisation	Organisation	NNP
cord-335198-qp964238	32	43	's	's	POS
cord-335198-qp964238	32	44	"	"	``
cord-335198-qp964238	32	45	Solidarity	Solidarity	NNP
cord-335198-qp964238	32	46	"	"	''
cord-335198-qp964238	32	47	trial	trial	NN
cord-335198-qp964238	32	48	(	(	-LRB-
cord-335198-qp964238	32	49	see	see	VB
cord-335198-qp964238	32	50	below	below	RB
cord-335198-qp964238	32	51	)	)	-RRB-
cord-335198-qp964238	32	52	.	.	.
cord-335198-qp964238	33	1	Ideally	ideally	RB
cord-335198-qp964238	33	2	this	this	DT
cord-335198-qp964238	33	3	list	list	NN
cord-335198-qp964238	33	4	should	should	MD
cord-335198-qp964238	33	5	be	be	VB
cord-335198-qp964238	33	6	extended	extend	VBN
cord-335198-qp964238	33	7	to	to	IN
cord-335198-qp964238	33	8	all	all	DT
cord-335198-qp964238	33	9	other	other	JJ
cord-335198-qp964238	33	10	therapies	therapy	NNS
cord-335198-qp964238	33	11	where	where	WRB
cord-335198-qp964238	33	12	there	there	EX
cord-335198-qp964238	33	13	may	may	MD
cord-335198-qp964238	33	14	be	be	VB
cord-335198-qp964238	33	15	a	a	DT
cord-335198-qp964238	33	16	potential	potential	JJ
cord-335198-qp964238	33	17	benefit	benefit	NN
cord-335198-qp964238	33	18	seemingly	seemingly	RB
cord-335198-qp964238	33	19	counterbalanced	counterbalance	VBN
cord-335198-qp964238	33	20	by	by	IN
cord-335198-qp964238	33	21	potential	potential	JJ
cord-335198-qp964238	33	22	risk	risk	NN
cord-335198-qp964238	33	23	.	.	.
cord-335198-qp964238	34	1	However	however	RB
cord-335198-qp964238	34	2	,	,	,
cord-335198-qp964238	34	3	at	at	IN
cord-335198-qp964238	34	4	all	all	DT
cord-335198-qp964238	34	5	points	point	NNS
cord-335198-qp964238	34	6	decisions	decision	NNS
cord-335198-qp964238	34	7	will	will	MD
cord-335198-qp964238	34	8	need	need	VB
cord-335198-qp964238	34	9	to	to	TO
cord-335198-qp964238	34	10	be	be	VB
cord-335198-qp964238	34	11	weighed	weigh	VBN
cord-335198-qp964238	34	12	and	and	CC
cord-335198-qp964238	34	13	taken	take	VBN
cord-335198-qp964238	34	14	.	.	.
cord-335198-qp964238	35	1	Which	which	WDT
cord-335198-qp964238	35	2	drugs	drug	NNS
cord-335198-qp964238	35	3	to	to	IN
cord-335198-qp964238	35	4	trial	trial	NN
cord-335198-qp964238	35	5	?	?	.
cord-335198-qp964238	36	1	Which	which	WDT
cord-335198-qp964238	36	2	patients	patient	NNS
cord-335198-qp964238	36	3	?	?	.
cord-335198-qp964238	37	1	What	what	WDT
cord-335198-qp964238	37	2	disease	disease	NN
cord-335198-qp964238	37	3	severity	severity	NN
cord-335198-qp964238	37	4	?	?	.
cord-335198-qp964238	38	1	What	what	WP
cord-335198-qp964238	38	2	dose	dose	NN
cord-335198-qp964238	38	3	?	?	.
cord-335198-qp964238	39	1	What	what	WP
cord-335198-qp964238	39	2	to	to	TO
cord-335198-qp964238	39	3	measure	measure	VB
cord-335198-qp964238	39	4	?	?	.
cord-335198-qp964238	39	5	,	,	,
cord-335198-qp964238	39	6	and	and	CC
cord-335198-qp964238	39	7	how	how	WRB
cord-335198-qp964238	39	8	?	?	.
cord-335198-qp964238	39	9	,	,	,
cord-335198-qp964238	39	10	and	and	CC
cord-335198-qp964238	39	11	why	why	WRB
cord-335198-qp964238	39	12	?	?	.
cord-335198-qp964238	40	1	Which	which	WDT
cord-335198-qp964238	40	2	endpoints	endpoint	NNS
cord-335198-qp964238	40	3	?	?	.
cord-335198-qp964238	41	1	How	how	WRB
cord-335198-qp964238	41	2	to	to	TO
cord-335198-qp964238	41	3	adjust	adjust	VB
cord-335198-qp964238	41	4	for	for	IN
cord-335198-qp964238	41	5	confounder	confounder	NN
cord-335198-qp964238	41	6	variables	variable	NNS
cord-335198-qp964238	41	7	?	?	.
cord-335198-qp964238	42	1	How	how	WRB
cord-335198-qp964238	42	2	many	many	JJ
cord-335198-qp964238	42	3	patients	patient	NNS
cord-335198-qp964238	42	4	?	?	.
cord-335198-qp964238	43	1	Additionally	additionally	RB
cord-335198-qp964238	43	2	,	,	,
cord-335198-qp964238	43	3	analytic	analytic	JJ
cord-335198-qp964238	43	4	integrity	integrity	NN
cord-335198-qp964238	43	5	is	be	VBZ
cord-335198-qp964238	43	6	all	all	DT
cord-335198-qp964238	43	7	.	.	.
cord-335198-qp964238	44	1	Not	not	RB
cord-335198-qp964238	44	2	enough	enough	JJ
cord-335198-qp964238	44	3	design	design	NN
cord-335198-qp964238	44	4	control	control	NN
cord-335198-qp964238	44	5	and	and	CC
cord-335198-qp964238	44	6	internal	internal	JJ
cord-335198-qp964238	44	7	validity	validity	NN
cord-335198-qp964238	44	8	is	be	VBZ
cord-335198-qp964238	44	9	threatened	threaten	VBN
cord-335198-qp964238	44	10	,	,	,
cord-335198-qp964238	44	11	too	too	RB
cord-335198-qp964238	44	12	much	much	JJ
cord-335198-qp964238	44	13	and	and	CC
cord-335198-qp964238	44	14	there	there	EX
cord-335198-qp964238	44	15	will	will	MD
cord-335198-qp964238	44	16	be	be	VB
cord-335198-qp964238	44	17	a	a	DT
cord-335198-qp964238	44	18	problem	problem	NN
cord-335198-qp964238	44	19	with	with	IN
cord-335198-qp964238	44	20	external	external	JJ
cord-335198-qp964238	44	21	validity	validity	NN
cord-335198-qp964238	44	22	.	.	.
cord-335198-qp964238	45	1	Even	even	RB
cord-335198-qp964238	45	2	with	with	IN
cord-335198-qp964238	45	3	well	well	RB
cord-335198-qp964238	45	4	-	-	HYPH
cord-335198-qp964238	45	5	controlled	control	VBN
cord-335198-qp964238	45	6	RCTs	rct	NNS
cord-335198-qp964238	45	7	for	for	IN
cord-335198-qp964238	45	8	specific	specific	JJ
cord-335198-qp964238	45	9	agents	agent	NNS
cord-335198-qp964238	45	10	uncertainty	uncertainty	NN
cord-335198-qp964238	45	11	can	can	MD
cord-335198-qp964238	45	12	never	never	RB
cord-335198-qp964238	45	13	be	be	VB
cord-335198-qp964238	45	14	completely	completely	RB
cord-335198-qp964238	45	15	eliminated	eliminate	VBN
cord-335198-qp964238	45	16	.	.	.
cord-335198-qp964238	46	1	The	the	DT
cord-335198-qp964238	46	2	best	good	JJS
cord-335198-qp964238	46	3	we	-PRON-	PRP
cord-335198-qp964238	46	4	can	can	MD
cord-335198-qp964238	46	5	hope	hope	VB
cord-335198-qp964238	46	6	for	for	IN
cord-335198-qp964238	46	7	is	be	VBZ
cord-335198-qp964238	46	8	to	to	TO
cord-335198-qp964238	46	9	optimally	optimally	RB
cord-335198-qp964238	46	10	quantify	quantify	VB
cord-335198-qp964238	46	11	key	key	JJ
cord-335198-qp964238	46	12	uncertainties	uncertainty	NNS
cord-335198-qp964238	46	13	thereby	thereby	RB
cord-335198-qp964238	46	14	elevating	elevate	VBG
cord-335198-qp964238	46	15	our	-PRON-	PRP$
cord-335198-qp964238	46	16	certainty	certainty	NN
cord-335198-qp964238	46	17	base	base	NN
cord-335198-qp964238	46	18	for	for	IN
cord-335198-qp964238	46	19	future	future	JJ
cord-335198-qp964238	46	20	decision	decision	NN
cord-335198-qp964238	46	21	-	-	HYPH
cord-335198-qp964238	46	22	making	making	NN
cord-335198-qp964238	46	23	.	.	.
cord-335198-qp964238	47	1	The	the	DT
cord-335198-qp964238	47	2	more	more	RBR
cord-335198-qp964238	47	3	iterative	iterative	JJ
cord-335198-qp964238	47	4	this	this	DT
cord-335198-qp964238	47	5	process	process	NN
cord-335198-qp964238	47	6	can	can	MD
cord-335198-qp964238	47	7	be	be	VB
cord-335198-qp964238	47	8	,	,	,
cord-335198-qp964238	47	9	the	the	DT
cord-335198-qp964238	47	10	better	well	JJR
cord-335198-qp964238	47	11	.	.	.
cord-335198-qp964238	48	1	Notwithstanding	notwithstanding	IN
cord-335198-qp964238	48	2	this	this	DT
cord-335198-qp964238	48	3	however	however	RB
cord-335198-qp964238	48	4	,	,	,
cord-335198-qp964238	48	5	there	there	EX
cord-335198-qp964238	48	6	will	will	MD
cord-335198-qp964238	48	7	always	always	RB
cord-335198-qp964238	48	8	be	be	VB
cord-335198-qp964238	48	9	a	a	DT
cord-335198-qp964238	48	10	tension	tension	NN
cord-335198-qp964238	48	11	between	between	IN
cord-335198-qp964238	48	12	the	the	DT
cord-335198-qp964238	48	13	ideal	ideal	NN
cord-335198-qp964238	48	14	of	of	IN
cord-335198-qp964238	48	15	increasingly	increasingly	RB
cord-335198-qp964238	48	16	covering	cover	VBG
cord-335198-qp964238	48	17	all	all	DT
cord-335198-qp964238	48	18	testing	testing	NN
cord-335198-qp964238	48	19	possibilities	possibility	NNS
cord-335198-qp964238	48	20	for	for	IN
cord-335198-qp964238	48	21	completeness	completeness	NN
cord-335198-qp964238	48	22	and	and	CC
cord-335198-qp964238	48	23	the	the	DT
cord-335198-qp964238	48	24	practicalities	practicality	NNS
cord-335198-qp964238	48	25	of	of	IN
cord-335198-qp964238	48	26	getting	get	VBG
cord-335198-qp964238	48	27	on	on	RP
cord-335198-qp964238	48	28	with	with	IN
cord-335198-qp964238	48	29	the	the	DT
cord-335198-qp964238	48	30	real	real	JJ
cord-335198-qp964238	48	31	-	-	HYPH
cord-335198-qp964238	48	32	time	time	NN
cord-335198-qp964238	48	33	demands	demand	NNS
cord-335198-qp964238	48	34	of	of	IN
cord-335198-qp964238	48	35	work	work	NN
cord-335198-qp964238	48	36	to	to	TO
cord-335198-qp964238	48	37	be	be	VB
cord-335198-qp964238	48	38	done	do	VBN
cord-335198-qp964238	48	39	.	.	.
cord-335198-qp964238	49	1	Paradoxically	paradoxically	RB
cord-335198-qp964238	49	2	,	,	,
cord-335198-qp964238	49	3	the	the	DT
cord-335198-qp964238	49	4	almost	almost	RB
cord-335198-qp964238	49	5	immediate	immediate	JJ
cord-335198-qp964238	49	6	establishment	establishment	NN
cord-335198-qp964238	49	7	of	of	IN
cord-335198-qp964238	49	8	a	a	DT
cord-335198-qp964238	49	9	well	well	RB
cord-335198-qp964238	49	10	-	-	HYPH
cord-335198-qp964238	49	11	designed	design	VBN
cord-335198-qp964238	49	12	RCT	RCT	NNP
cord-335198-qp964238	49	13	to	to	TO
cord-335198-qp964238	49	14	test	test	VB
cord-335198-qp964238	49	15	the	the	DT
cord-335198-qp964238	49	16	combination	combination	NN
cord-335198-qp964238	49	17	antiviral	antiviral	JJ
cord-335198-qp964238	49	18	treatment	treatment	NN
cord-335198-qp964238	49	19	lopinavir	lopinavir	NNS
cord-335198-qp964238	49	20	-	-	HYPH
cord-335198-qp964238	49	21	ritonavir	ritonavir	NNS
cord-335198-qp964238	49	22	in	in	IN
cord-335198-qp964238	49	23	Wuhan	Wuhan	NNP
cord-335198-qp964238	49	24	,	,	,
cord-335198-qp964238	49	25	China	China	NNP
cord-335198-qp964238	49	26	during	during	IN
cord-335198-qp964238	49	27	the	the	DT
cord-335198-qp964238	49	28	beginning	beginning	NN
cord-335198-qp964238	49	29	of	of	IN
cord-335198-qp964238	49	30	the	the	DT
cord-335198-qp964238	49	31	pandemic	pandemic	NN
cord-335198-qp964238	49	32	exemplified	exemplify	VBD
cord-335198-qp964238	49	33	this	this	DT
cord-335198-qp964238	49	34	tension	tension	NN
cord-335198-qp964238	49	35	in	in	IN
cord-335198-qp964238	49	36	a	a	DT
cord-335198-qp964238	49	37	most	most	RBS
cord-335198-qp964238	49	38	unusual	unusual	JJ
cord-335198-qp964238	49	39	way	way	NN
cord-335198-qp964238	49	40	when	when	WRB
cord-335198-qp964238	49	41	trial	trial	NN
cord-335198-qp964238	49	42	recruitment	recruitment	NN
cord-335198-qp964238	49	43	ceased	cease	VBD
cord-335198-qp964238	49	44	early	early	RB
cord-335198-qp964238	49	45	due	due	IN
cord-335198-qp964238	49	46	to	to	IN
cord-335198-qp964238	49	47	falling	fall	VBG
cord-335198-qp964238	49	48	COVID19	COVID19	NNP
cord-335198-qp964238	49	49	case	case	NN
cord-335198-qp964238	49	50	numbers	number	NNS
cord-335198-qp964238	49	51	(	(	-LRB-
cord-335198-qp964238	49	52	7	7	CD
cord-335198-qp964238	49	53	)	)	-RRB-
cord-335198-qp964238	49	54	.	.	.
cord-335198-qp964238	50	1	It	-PRON-	PRP
cord-335198-qp964238	50	2	is	be	VBZ
cord-335198-qp964238	50	3	clearly	clearly	RB
cord-335198-qp964238	50	4	not	not	RB
cord-335198-qp964238	50	5	possible	possible	JJ
cord-335198-qp964238	50	6	to	to	TO
cord-335198-qp964238	50	7	immediately	immediately	RB
cord-335198-qp964238	50	8	perform	perform	VB
cord-335198-qp964238	50	9	a	a	DT
cord-335198-qp964238	50	10	well	well	RB
cord-335198-qp964238	50	11	-	-	HYPH
cord-335198-qp964238	50	12	controlled	control	VBN
cord-335198-qp964238	50	13	RCT	RCT	NNP
cord-335198-qp964238	50	14	on	on	IN
cord-335198-qp964238	50	15	all	all	DT
cord-335198-qp964238	50	16	potentially	potentially	RB
cord-335198-qp964238	50	17	useful	useful	JJ
cord-335198-qp964238	50	18	therapies	therapy	NNS
cord-335198-qp964238	50	19	.	.	.
cord-335198-qp964238	51	1	Hence	hence	RB
cord-335198-qp964238	51	2	,	,	,
cord-335198-qp964238	51	3	in	in	IN
cord-335198-qp964238	51	4	trying	try	VBG
cord-335198-qp964238	51	5	to	to	TO
cord-335198-qp964238	51	6	do	do	VB
cord-335198-qp964238	51	7	everything	everything	NN
cord-335198-qp964238	51	8	one	one	PRP
cord-335198-qp964238	51	9	can	can	MD
cord-335198-qp964238	51	10	for	for	IN
cord-335198-qp964238	51	11	individual	individual	JJ
cord-335198-qp964238	51	12	patients	patient	NNS
cord-335198-qp964238	51	13	with	with	IN
cord-335198-qp964238	51	14	severe	severe	JJ
cord-335198-qp964238	51	15	disease	disease	NN
cord-335198-qp964238	51	16	who	who	WP
cord-335198-qp964238	51	17	are	be	VBP
cord-335198-qp964238	51	18	likely	likely	JJ
cord-335198-qp964238	51	19	to	to	TO
cord-335198-qp964238	51	20	die	die	VB
cord-335198-qp964238	51	21	it	-PRON-	PRP
cord-335198-qp964238	51	22	is	be	VBZ
cord-335198-qp964238	51	23	compassionate	compassionate	JJ
cord-335198-qp964238	51	24	and	and	CC
cord-335198-qp964238	51	25	reasonable	reasonable	JJ
cord-335198-qp964238	51	26	to	to	TO
cord-335198-qp964238	51	27	empirically	empirically	RB
cord-335198-qp964238	51	28	trial	trial	NN
cord-335198-qp964238	51	29	available	available	JJ
cord-335198-qp964238	51	30	products	product	NNS
cord-335198-qp964238	51	31	off	off	IN
cord-335198-qp964238	51	32	-	-	HYPH
cord-335198-qp964238	51	33	label	label	NN
cord-335198-qp964238	51	34	where	where	WRB
cord-335198-qp964238	51	35	the	the	DT
cord-335198-qp964238	51	36	existing	exist	VBG
cord-335198-qp964238	51	37	information	information	NN
cord-335198-qp964238	51	38	base	base	NN
cord-335198-qp964238	51	39	suggests	suggest	VBZ
cord-335198-qp964238	51	40	potential	potential	JJ
cord-335198-qp964238	51	41	benefit	benefit	NN
cord-335198-qp964238	51	42	outweighing	outweigh	VBG
cord-335198-qp964238	51	43	any	any	DT
cord-335198-qp964238	51	44	potential	potential	JJ
cord-335198-qp964238	51	45	harm	harm	NN
cord-335198-qp964238	51	46	.	.	.
cord-335198-qp964238	52	1	This	this	DT
cord-335198-qp964238	52	2	of	of	IN
cord-335198-qp964238	52	3	course	course	RB
cord-335198-qp964238	52	4	all	all	DT
cord-335198-qp964238	52	5	turns	turn	VBZ
cord-335198-qp964238	52	6	on	on	IN
cord-335198-qp964238	52	7	our	-PRON-	PRP$
cord-335198-qp964238	52	8	shared	shared	JJ
cord-335198-qp964238	52	9	understanding	understanding	NN
cord-335198-qp964238	52	10	of	of	IN
cord-335198-qp964238	52	11	"	"	``
cord-335198-qp964238	52	12	likely	likely	JJ
cord-335198-qp964238	52	13	to	to	TO
cord-335198-qp964238	52	14	die	die	VB
cord-335198-qp964238	52	15	"	"	''
cord-335198-qp964238	52	16	,	,	,
cord-335198-qp964238	52	17	"	"	''
cord-335198-qp964238	52	18	likely	likely	JJ
cord-335198-qp964238	52	19	to	to	TO
cord-335198-qp964238	52	20	benefit	benefit	VB
cord-335198-qp964238	52	21	"	"	''
cord-335198-qp964238	52	22	and	and	CC
cord-335198-qp964238	52	23	"	"	``
cord-335198-qp964238	52	24	potential	potential	NN
cord-335198-qp964238	52	25	for	for	IN
cord-335198-qp964238	52	26	harm	harm	NN
cord-335198-qp964238	52	27	"	"	''
cord-335198-qp964238	52	28	at	at	IN
cord-335198-qp964238	52	29	the	the	DT
cord-335198-qp964238	52	30	very	very	RB
cord-335198-qp964238	52	31	least	least	JJS
cord-335198-qp964238	52	32	.	.	.
cord-335198-qp964238	53	1	The	the	DT
cord-335198-qp964238	53	2	more	more	RBR
cord-335198-qp964238	53	3	we	-PRON-	PRP
cord-335198-qp964238	53	4	use	use	VBP
cord-335198-qp964238	53	5	these	these	DT
cord-335198-qp964238	53	6	therapies	therapy	NNS
cord-335198-qp964238	53	7	however	however	RB
cord-335198-qp964238	53	8	in	in	IN
cord-335198-qp964238	53	9	patients	patient	NNS
cord-335198-qp964238	53	10	with	with	IN
cord-335198-qp964238	53	11	less	less	RBR
cord-335198-qp964238	53	12	severe	severe	JJ
cord-335198-qp964238	53	13	illness	illness	NN
cord-335198-qp964238	53	14	,	,	,
cord-335198-qp964238	53	15	where	where	WRB
cord-335198-qp964238	53	16	the	the	DT
cord-335198-qp964238	53	17	uncontrolled	uncontrolled	JJ
cord-335198-qp964238	53	18	benefit	benefit	NN
cord-335198-qp964238	53	19	signal	signal	NN
cord-335198-qp964238	53	20	may	may	MD
cord-335198-qp964238	53	21	be	be	VB
cord-335198-qp964238	53	22	significantly	significantly	RB
cord-335198-qp964238	53	23	"	"	``
cord-335198-qp964238	53	24	overcalled	overcalle	VBN
cord-335198-qp964238	53	25	"	"	''
cord-335198-qp964238	53	26	by	by	IN
cord-335198-qp964238	53	27	a	a	DT
cord-335198-qp964238	53	28	positive	positive	JJ
cord-335198-qp964238	53	29	natural	natural	JJ
cord-335198-qp964238	53	30	history	history	NN
cord-335198-qp964238	53	31	and	and	CC
cord-335198-qp964238	53	32	the	the	DT
cord-335198-qp964238	53	33	risks	risk	NNS
cord-335198-qp964238	53	34	of	of	IN
cord-335198-qp964238	53	35	harm	harm	NN
cord-335198-qp964238	53	36	may	may	MD
cord-335198-qp964238	53	37	become	become	VB
cord-335198-qp964238	53	38	increasingly	increasingly	RB
cord-335198-qp964238	53	39	unacceptable	unacceptable	JJ
cord-335198-qp964238	53	40	,	,	,
cord-335198-qp964238	53	41	the	the	DT
cord-335198-qp964238	53	42	more	more	RBR
cord-335198-qp964238	53	43	it	-PRON-	PRP
cord-335198-qp964238	53	44	behoves	behove	VBZ
cord-335198-qp964238	53	45	us	-PRON-	PRP
cord-335198-qp964238	53	46	to	to	TO
cord-335198-qp964238	53	47	go	go	VB
cord-335198-qp964238	53	48	down	down	IN
cord-335198-qp964238	53	49	the	the	DT
cord-335198-qp964238	53	50	path	path	NN
cord-335198-qp964238	53	51	of	of	IN
cord-335198-qp964238	53	52	a	a	DT
cord-335198-qp964238	53	53	properly	properly	RB
cord-335198-qp964238	53	54	controlled	control	VBN
cord-335198-qp964238	53	55	and	and	CC
cord-335198-qp964238	53	56	conducted	conduct	VBN
cord-335198-qp964238	53	57	RCT	RCT	NNP
cord-335198-qp964238	53	58	.	.	.
cord-335198-qp964238	54	1	Excellence	excellence	NN
cord-335198-qp964238	54	2	here	here	RB
cord-335198-qp964238	54	3	is	be	VBZ
cord-335198-qp964238	54	4	not	not	RB
cord-335198-qp964238	54	5	the	the	DT
cord-335198-qp964238	54	6	enemy	enemy	NN
cord-335198-qp964238	54	7	of	of	IN
cord-335198-qp964238	54	8	"	"	``
cord-335198-qp964238	54	9	good	good	JJ
cord-335198-qp964238	54	10	enough	enough	RB
cord-335198-qp964238	54	11	"	"	''
cord-335198-qp964238	54	12	as	as	IN
cord-335198-qp964238	54	13	may	may	MD
cord-335198-qp964238	54	14	be	be	VB
cord-335198-qp964238	54	15	argued	argue	VBN
cord-335198-qp964238	54	16	in	in	IN
cord-335198-qp964238	54	17	the	the	DT
cord-335198-qp964238	54	18	exceptional	exceptional	JJ
cord-335198-qp964238	54	19	circumstances	circumstance	NNS
cord-335198-qp964238	54	20	of	of	IN
cord-335198-qp964238	54	21	a	a	DT
cord-335198-qp964238	54	22	pandemic	pandemic	NN
cord-335198-qp964238	54	23	or	or	CC
cord-335198-qp964238	54	24	indeed	indeed	RB
cord-335198-qp964238	54	25	any	any	DT
cord-335198-qp964238	54	26	uniquely	uniquely	RB
cord-335198-qp964238	54	27	uncertain	uncertain	JJ
cord-335198-qp964238	54	28	area	area	NN
cord-335198-qp964238	54	29	of	of	IN
cord-335198-qp964238	54	30	clinical	clinical	JJ
cord-335198-qp964238	54	31	medicine	medicine	NN
cord-335198-qp964238	54	32	but	but	CC
cord-335198-qp964238	54	33	the	the	DT
cord-335198-qp964238	54	34	standard	standard	NN
cord-335198-qp964238	54	35	that	that	WDT
cord-335198-qp964238	54	36	should	should	MD
cord-335198-qp964238	54	37	always	always	RB
cord-335198-qp964238	54	38	be	be	VB
cord-335198-qp964238	54	39	aspired	aspire	VBN
cord-335198-qp964238	54	40	to	to	IN
cord-335198-qp964238	54	41	.	.	.
cord-335198-qp964238	55	1	Indeed	indeed	RB
cord-335198-qp964238	55	2	,	,	,
cord-335198-qp964238	55	3	an	an	DT
cord-335198-qp964238	55	4	enlightened	enlightened	JJ
cord-335198-qp964238	55	5	view	view	NN
cord-335198-qp964238	55	6	of	of	IN
cord-335198-qp964238	55	7	excellence	excellence	NN
cord-335198-qp964238	55	8	would	would	MD
cord-335198-qp964238	55	9	expand	expand	VB
cord-335198-qp964238	55	10	its	-PRON-	PRP$
cord-335198-qp964238	55	11	horizon	horizon	NN
cord-335198-qp964238	55	12	to	to	TO
cord-335198-qp964238	55	13	embrace	embrace	VB
cord-335198-qp964238	55	14	"	"	``
cord-335198-qp964238	55	15	good	good	JJ
cord-335198-qp964238	55	16	enough	enough	RB
cord-335198-qp964238	55	17	"	"	''
cord-335198-qp964238	55	18	in	in	IN
cord-335198-qp964238	55	19	the	the	DT
cord-335198-qp964238	55	20	most	most	RBS
cord-335198-qp964238	55	21	excellent	excellent	JJ
cord-335198-qp964238	55	22	way	way	NN
cord-335198-qp964238	55	23	possible	possible	JJ
cord-335198-qp964238	55	24	for	for	IN
cord-335198-qp964238	55	25	any	any	DT
cord-335198-qp964238	55	26	specific	specific	JJ
cord-335198-qp964238	55	27	situation	situation	NN
cord-335198-qp964238	55	28	.	.	.
cord-335198-qp964238	56	1	Anything	anything	NN
cord-335198-qp964238	56	2	less	less	JJR
cord-335198-qp964238	56	3	than	than	IN
cord-335198-qp964238	56	4	this	this	DT
cord-335198-qp964238	56	5	is	be	VBZ
cord-335198-qp964238	56	6	professionally	professionally	RB
cord-335198-qp964238	56	7	and	and	CC
cord-335198-qp964238	56	8	personally	personally	RB
cord-335198-qp964238	56	9	diminishing	diminish	VBG
cord-335198-qp964238	56	10	as	as	IN
cord-335198-qp964238	56	11	it	-PRON-	PRP
cord-335198-qp964238	56	12	quickly	quickly	RB
cord-335198-qp964238	56	13	contracts	contract	VBZ
cord-335198-qp964238	56	14	down	down	RP
cord-335198-qp964238	56	15	to	to	IN
cord-335198-qp964238	56	16	no	no	DT
cord-335198-qp964238	56	17	-	-	HYPH
cord-335198-qp964238	56	18	risk	risk	NN
cord-335198-qp964238	56	19	comfort	comfort	NN
cord-335198-qp964238	56	20	zones	zone	NNS
cord-335198-qp964238	56	21	and	and	CC
cord-335198-qp964238	56	22	sets	set	VBZ
cord-335198-qp964238	56	23	us	-PRON-	PRP
cord-335198-qp964238	56	24	down	down	IN
cord-335198-qp964238	56	25	the	the	DT
cord-335198-qp964238	56	26	murky	murky	JJ
cord-335198-qp964238	56	27	path	path	NN
cord-335198-qp964238	56	28	of	of	IN
cord-335198-qp964238	56	29	"	"	``
cord-335198-qp964238	56	30	good	good	JJ
cord-335198-qp964238	56	31	enough	enough	RB
cord-335198-qp964238	56	32	for	for	IN
cord-335198-qp964238	56	33	who	who	WP
cord-335198-qp964238	56	34	"	"	``
cord-335198-qp964238	56	35	questions	question	NNS
cord-335198-qp964238	56	36	and	and	CC
cord-335198-qp964238	56	37	excusable	excusable	JJ
cord-335198-qp964238	56	38	actions	action	NNS
cord-335198-qp964238	56	39	that	that	WDT
cord-335198-qp964238	56	40	are	be	VBP
cord-335198-qp964238	56	41	answerable	answerable	JJ
cord-335198-qp964238	56	42	to	to	IN
cord-335198-qp964238	56	43	noone	noone	NN
cord-335198-qp964238	56	44	.	.	.
cord-335198-qp964238	57	1	Under	under	IN
cord-335198-qp964238	57	2	pandemic	pandemic	JJ
cord-335198-qp964238	57	3	conditions	condition	NNS
cord-335198-qp964238	57	4	of	of	IN
cord-335198-qp964238	57	5	overwhelming	overwhelming	JJ
cord-335198-qp964238	57	6	health	health	NN
cord-335198-qp964238	57	7	-	-	HYPH
cord-335198-qp964238	57	8	care	care	NN
cord-335198-qp964238	57	9	system	system	NN
cord-335198-qp964238	57	10	stress	stress	NN
cord-335198-qp964238	57	11	and	and	CC
cord-335198-qp964238	57	12	understandable	understandable	JJ
cord-335198-qp964238	57	13	urgencies	urgency	NNS
cord-335198-qp964238	57	14	to	to	TO
cord-335198-qp964238	57	15	try	try	VB
cord-335198-qp964238	57	16	untested	untested	JJ
cord-335198-qp964238	57	17	therapies	therapy	NNS
cord-335198-qp964238	57	18	,	,	,
cord-335198-qp964238	57	19	the	the	DT
cord-335198-qp964238	57	20	introduction	introduction	NN
cord-335198-qp964238	57	21	of	of	IN
cord-335198-qp964238	57	22	novel	novel	JJ
cord-335198-qp964238	57	23	therapeutic	therapeutic	JJ
cord-335198-qp964238	57	24	practices	practice	NNS
cord-335198-qp964238	57	25	may	may	MD
cord-335198-qp964238	57	26	therefore	therefore	RB
cord-335198-qp964238	57	27	take	take	VB
cord-335198-qp964238	57	28	on	on	RP
cord-335198-qp964238	57	29	a	a	DT
cord-335198-qp964238	57	30	life	life	NN
cord-335198-qp964238	57	31	of	of	IN
cord-335198-qp964238	57	32	its	-PRON-	PRP$
cord-335198-qp964238	57	33	own	own	JJ
cord-335198-qp964238	57	34	and	and	CC
cord-335198-qp964238	57	35	become	become	VBP
cord-335198-qp964238	57	36	disproportionately	disproportionately	RB
cord-335198-qp964238	57	37	uncoupled	uncouple	VBN
cord-335198-qp964238	57	38	from	from	IN
cord-335198-qp964238	57	39	any	any	DT
cord-335198-qp964238	57	40	primary	primary	JJ
cord-335198-qp964238	57	41	purpose	purpose	NN
cord-335198-qp964238	57	42	.	.	.
cord-335198-qp964238	58	1	Hence	hence	RB
cord-335198-qp964238	58	2	,	,	,
cord-335198-qp964238	58	3	randomly	randomly	RB
cord-335198-qp964238	58	4	collected	collect	VBN
cord-335198-qp964238	58	5	case	case	NN
cord-335198-qp964238	58	6	series	series	NN
cord-335198-qp964238	58	7	and	and	CC
cord-335198-qp964238	58	8	uncontrolled	uncontrolled	JJ
cord-335198-qp964238	58	9	smaller	small	JJR
cord-335198-qp964238	58	10	trials	trial	NNS
cord-335198-qp964238	58	11	may	may	MD
cord-335198-qp964238	58	12	proliferate	proliferate	VB
cord-335198-qp964238	58	13	without	without	IN
cord-335198-qp964238	58	14	necessarily	necessarily	RB
cord-335198-qp964238	58	15	being	be	VBG
cord-335198-qp964238	58	16	in	in	IN
cord-335198-qp964238	58	17	the	the	DT
cord-335198-qp964238	58	18	best	good	JJS
cord-335198-qp964238	58	19	interests	interest	NNS
cord-335198-qp964238	58	20	of	of	IN
cord-335198-qp964238	58	21	either	either	DT
cord-335198-qp964238	58	22	individual	individual	JJ
cord-335198-qp964238	58	23	patients	patient	NNS
cord-335198-qp964238	58	24	or	or	CC
cord-335198-qp964238	58	25	specific	specific	JJ
cord-335198-qp964238	58	26	patient	patient	JJ
cord-335198-qp964238	58	27	cohorts	cohort	NNS
cord-335198-qp964238	58	28	.	.	.
cord-335198-qp964238	59	1	The	the	DT
cord-335198-qp964238	59	2	example	example	NN
cord-335198-qp964238	59	3	of	of	IN
cord-335198-qp964238	59	4	hydroxychloroquine	hydroxychloroquine	NNP
cord-335198-qp964238	59	5	/	/	SYM
cord-335198-qp964238	59	6	chloroquine	chloroquine	NNP
cord-335198-qp964238	59	7	is	be	VBZ
cord-335198-qp964238	59	8	a	a	DT
cord-335198-qp964238	59	9	case	case	NN
cord-335198-qp964238	59	10	in	in	IN
cord-335198-qp964238	59	11	point	point	NN
cord-335198-qp964238	59	12	where	where	WRB
cord-335198-qp964238	59	13	some	some	DT
cord-335198-qp964238	59	14	early	early	JJ
cord-335198-qp964238	59	15	in	in	IN
cord-335198-qp964238	59	16	vitro	vitro	FW
cord-335198-qp964238	59	17	evidence	evidence	NN
cord-335198-qp964238	59	18	of	of	IN
cord-335198-qp964238	59	19	efficacy	efficacy	NN
cord-335198-qp964238	59	20	against	against	IN
cord-335198-qp964238	59	21	SARS	SARS	NNP
cord-335198-qp964238	59	22	-	-	HYPH
cord-335198-qp964238	59	23	COV2	COV2	NNP
cord-335198-qp964238	59	24	has	have	VBZ
cord-335198-qp964238	59	25	been	be	VBN
cord-335198-qp964238	59	26	taken	take	VBN
cord-335198-qp964238	59	27	both	both	DT
cord-335198-qp964238	59	28	"	"	``
cord-335198-qp964238	59	29	too	too	RB
cord-335198-qp964238	59	30	far	far	RB
cord-335198-qp964238	59	31	"	"	''
cord-335198-qp964238	59	32	and	and	CC
cord-335198-qp964238	59	33	"	"	``
cord-335198-qp964238	59	34	not	not	RB
cord-335198-qp964238	59	35	far	far	RB
cord-335198-qp964238	59	36	enough	enough	RB
cord-335198-qp964238	59	37	"	"	''
cord-335198-qp964238	59	38	.	.	.
cord-335198-qp964238	60	1	Hence	hence	RB
cord-335198-qp964238	60	2	,	,	,
cord-335198-qp964238	60	3	it	-PRON-	PRP
cord-335198-qp964238	60	4	has	have	VBZ
cord-335198-qp964238	60	5	been	be	VBN
cord-335198-qp964238	60	6	used	use	VBN
cord-335198-qp964238	60	7	empirically	empirically	RB
cord-335198-qp964238	60	8	in	in	IN
cord-335198-qp964238	60	9	a	a	DT
cord-335198-qp964238	60	10	large	large	JJ
cord-335198-qp964238	60	11	,	,	,
cord-335198-qp964238	60	12	number	number	NN
cord-335198-qp964238	60	13	of	of	IN
cord-335198-qp964238	60	14	small	small	JJ
cord-335198-qp964238	60	15	and	and	CC
cord-335198-qp964238	60	16	uncontrolled	uncontrolled	JJ
cord-335198-qp964238	60	17	"	"	``
cord-335198-qp964238	60	18	trials	trial	NNS
cord-335198-qp964238	60	19	"	"	''
cord-335198-qp964238	60	20	around	around	IN
cord-335198-qp964238	60	21	the	the	DT
cord-335198-qp964238	60	22	world	world	NN
cord-335198-qp964238	60	23	despite	despite	IN
cord-335198-qp964238	60	24	its	-PRON-	PRP$
cord-335198-qp964238	60	25	potential	potential	NN
cord-335198-qp964238	60	26	for	for	IN
cord-335198-qp964238	60	27	cardiac	cardiac	JJ
cord-335198-qp964238	60	28	toxicity	toxicity	NN
cord-335198-qp964238	60	29	,	,	,
cord-335198-qp964238	60	30	and	and	CC
cord-335198-qp964238	60	31	in	in	IN
cord-335198-qp964238	60	32	one	one	CD
cord-335198-qp964238	60	33	larger	large	JJR
cord-335198-qp964238	60	34	,	,	,
cord-335198-qp964238	60	35	poorly	poorly	RB
cord-335198-qp964238	60	36	controlled	control	VBN
cord-335198-qp964238	60	37	observational	observational	JJ
cord-335198-qp964238	60	38	study	study	NN
cord-335198-qp964238	60	39	no	no	DT
cord-335198-qp964238	60	40	significant	significant	JJ
cord-335198-qp964238	60	41	benefit	benefit	NN
cord-335198-qp964238	60	42	and	and	CC
cord-335198-qp964238	60	43	potential	potential	NN
cord-335198-qp964238	60	44	for	for	IN
cord-335198-qp964238	60	45	significant	significant	JJ
cord-335198-qp964238	60	46	harm	harm	NN
cord-335198-qp964238	60	47	signal	signal	NN
cord-335198-qp964238	60	48	(	(	-LRB-
cord-335198-qp964238	60	49	8)	8)	NNP
cord-335198-qp964238	60	50	was	be	VBD
cord-335198-qp964238	60	51	inconclusive	inconclusive	JJ
cord-335198-qp964238	60	52	thereby	thereby	RB
cord-335198-qp964238	60	53	paving	pave	VBG
cord-335198-qp964238	60	54	the	the	DT
cord-335198-qp964238	60	55	way	way	NN
cord-335198-qp964238	60	56	for	for	IN
cord-335198-qp964238	60	57	rationalizing	rationalize	VBG
cord-335198-qp964238	60	58	any	any	DT
cord-335198-qp964238	60	59	position	position	NN
cord-335198-qp964238	60	60	you	-PRON-	PRP
cord-335198-qp964238	60	61	may	may	MD
cord-335198-qp964238	60	62	wish	wish	VB
cord-335198-qp964238	60	63	to	to	TO
cord-335198-qp964238	60	64	take	take	VB
cord-335198-qp964238	60	65	.	.	.
cord-335198-qp964238	61	1	More	more	RBR
cord-335198-qp964238	61	2	recently	recently	RB
cord-335198-qp964238	61	3	,	,	,
cord-335198-qp964238	61	4	the	the	DT
cord-335198-qp964238	61	5	controversial	controversial	JJ
cord-335198-qp964238	61	6	results	result	NNS
cord-335198-qp964238	61	7	of	of	IN
cord-335198-qp964238	61	8	a	a	DT
cord-335198-qp964238	61	9	multinational	multinational	JJ
cord-335198-qp964238	61	10	registry	registry	NN
cord-335198-qp964238	61	11	study	study	NN
cord-335198-qp964238	61	12	examining	examine	VBG
cord-335198-qp964238	61	13	the	the	DT
cord-335198-qp964238	61	14	risk	risk	NN
cord-335198-qp964238	61	15	/	/	SYM
cord-335198-qp964238	61	16	benefit	benefit	NN
cord-335198-qp964238	61	17	ratio	ratio	NN
cord-335198-qp964238	61	18	of	of	IN
cord-335198-qp964238	61	19	hydroxychloroquine	hydroxychloroquine	NN
cord-335198-qp964238	61	20	/	/	SYM
cord-335198-qp964238	61	21	chloroquine	chloroquine	NN
cord-335198-qp964238	61	22	with	with	IN
cord-335198-qp964238	61	23	or	or	CC
cord-335198-qp964238	61	24	without	without	IN
cord-335198-qp964238	61	25	macrolide	macrolide	NN
cord-335198-qp964238	61	26	for	for	IN
cord-335198-qp964238	61	27	treatment	treatment	NN
cord-335198-qp964238	61	28	of	of	IN
cord-335198-qp964238	61	29	COVID19	COVID19	NNP
cord-335198-qp964238	61	30	also	also	RB
cord-335198-qp964238	61	31	weighed	weigh	VBD
cord-335198-qp964238	61	32	into	into	IN
cord-335198-qp964238	61	33	the	the	DT
cord-335198-qp964238	61	34	evidence	evidence	NN
cord-335198-qp964238	61	35	debate	debate	NN
cord-335198-qp964238	61	36	only	only	RB
cord-335198-qp964238	61	37	to	to	TO
cord-335198-qp964238	61	38	now	now	RB
cord-335198-qp964238	61	39	be	be	VB
cord-335198-qp964238	61	40	retracted	retract	VBN
cord-335198-qp964238	61	41	by	by	IN
cord-335198-qp964238	61	42	the	the	DT
cord-335198-qp964238	61	43	authors	author	NNS
cord-335198-qp964238	61	44	(	(	-LRB-
cord-335198-qp964238	61	45	9	9	CD
cord-335198-qp964238	61	46	)	)	-RRB-
cord-335198-qp964238	61	47	.	.	.
cord-335198-qp964238	62	1	Add	add	VB
cord-335198-qp964238	62	2	to	to	IN
cord-335198-qp964238	62	3	this	this	DT
cord-335198-qp964238	62	4	a	a	DT
cord-335198-qp964238	62	5	heady	heady	JJ
cord-335198-qp964238	62	6	mixture	mixture	NN
cord-335198-qp964238	62	7	of	of	IN
cord-335198-qp964238	62	8	high	high	JJ
cord-335198-qp964238	62	9	profile	profile	NN
cord-335198-qp964238	62	10	,	,	,
cord-335198-qp964238	62	11	celebrity	celebrity	NN
cord-335198-qp964238	62	12	supporters	supporter	NNS
cord-335198-qp964238	62	13	and	and	CC
cord-335198-qp964238	62	14	trial	trial	NN
cord-335198-qp964238	62	15	by	by	IN
cord-335198-qp964238	62	16	media	medium	NNS
cord-335198-qp964238	62	17	and	and	CC
cord-335198-qp964238	62	18	you	-PRON-	PRP
cord-335198-qp964238	62	19	have	have	VBP
cord-335198-qp964238	62	20	a	a	DT
cord-335198-qp964238	62	21	recipe	recipe	NN
cord-335198-qp964238	62	22	for	for	IN
cord-335198-qp964238	62	23	compounding	compound	VBG
cord-335198-qp964238	62	24	one	one	CD
cord-335198-qp964238	62	25	crisis	crisis	NN
cord-335198-qp964238	62	26	with	with	IN
cord-335198-qp964238	62	27	another	another	DT
cord-335198-qp964238	62	28	.	.	.
cord-335198-qp964238	63	1	Also	also	RB
cord-335198-qp964238	63	2	,	,	,
cord-335198-qp964238	63	3	very	very	RB
cord-335198-qp964238	63	4	illuminating	illuminating	JJ
cord-335198-qp964238	63	5	is	be	VBZ
cord-335198-qp964238	63	6	the	the	DT
cord-335198-qp964238	63	7	story	story	NN
cord-335198-qp964238	63	8	of	of	IN
cord-335198-qp964238	63	9	the	the	DT
cord-335198-qp964238	63	10	antiviral	antiviral	JJ
cord-335198-qp964238	63	11	remdisivir	remdisivir	NNS
cord-335198-qp964238	63	12	.	.	.
cord-335198-qp964238	64	1	From	from	IN
cord-335198-qp964238	64	2	early	early	JJ
cord-335198-qp964238	64	3	,	,	,
cord-335198-qp964238	64	4	uncontrolled	uncontrolled	JJ
cord-335198-qp964238	64	5	results	result	NNS
cord-335198-qp964238	64	6	that	that	WDT
cord-335198-qp964238	64	7	reported	report	VBD
cord-335198-qp964238	64	8	a	a	DT
cord-335198-qp964238	64	9	clinical	clinical	JJ
cord-335198-qp964238	64	10	improvement	improvement	NN
cord-335198-qp964238	64	11	in	in	IN
cord-335198-qp964238	64	12	68	68	CD
cord-335198-qp964238	64	13	%	%	NN
cord-335198-qp964238	64	14	of	of	IN
cord-335198-qp964238	64	15	53	53	CD
cord-335198-qp964238	64	16	"	"	``
cord-335198-qp964238	64	17	analyzable	analyzable	JJ
cord-335198-qp964238	64	18	"	"	''
cord-335198-qp964238	64	19	patients	patient	NNS
cord-335198-qp964238	64	20	(	(	-LRB-
cord-335198-qp964238	64	21	10	10	CD
cord-335198-qp964238	64	22	)	)	-RRB-
cord-335198-qp964238	64	23	through	through	IN
cord-335198-qp964238	64	24	to	to	IN
cord-335198-qp964238	64	25	a	a	DT
cord-335198-qp964238	64	26	negative	negative	JJ
cord-335198-qp964238	64	27	RCT	RCT	NNP
cord-335198-qp964238	64	28	study	study	NN
cord-335198-qp964238	64	29	result	result	NN
cord-335198-qp964238	64	30	involving	involve	VBG
cord-335198-qp964238	64	31	236	236	CD
cord-335198-qp964238	64	32	patients	patient	NNS
cord-335198-qp964238	64	33	which	which	WDT
cord-335198-qp964238	64	34	was	be	VBD
cord-335198-qp964238	64	35	stopped	stop	VBN
cord-335198-qp964238	64	36	early	early	RB
cord-335198-qp964238	64	37	due	due	IN
cord-335198-qp964238	64	38	to	to	IN
cord-335198-qp964238	64	39	reduced	reduce	VBN
cord-335198-qp964238	64	40	case	case	NN
cord-335198-qp964238	64	41	numbers	number	NNS
cord-335198-qp964238	64	42	in	in	IN
cord-335198-qp964238	64	43	China	China	NNP
cord-335198-qp964238	64	44	resulting	result	VBG
cord-335198-qp964238	64	45	in	in	IN
cord-335198-qp964238	64	46	a	a	DT
cord-335198-qp964238	64	47	trial	trial	NN
cord-335198-qp964238	64	48	with	with	IN
cord-335198-qp964238	64	49	reduced	reduce	VBN
cord-335198-qp964238	64	50	power	power	NN
cord-335198-qp964238	64	51	to	to	TO
cord-335198-qp964238	64	52	detect	detect	VB
cord-335198-qp964238	64	53	any	any	DT
cord-335198-qp964238	64	54	smaller	small	JJR
cord-335198-qp964238	64	55	clinically	clinically	RB
cord-335198-qp964238	64	56	significant	significant	JJ
cord-335198-qp964238	64	57	benefit	benefit	NN
cord-335198-qp964238	64	58	with	with	IN
cord-335198-qp964238	64	59	any	any	DT
cord-335198-qp964238	64	60	certainty	certainty	NN
cord-335198-qp964238	64	61	(	(	-LRB-
cord-335198-qp964238	64	62	11	11	CD
cord-335198-qp964238	64	63	)	)	-RRB-
cord-335198-qp964238	64	64	to	to	IN
cord-335198-qp964238	64	65	further	further	JJ
cord-335198-qp964238	64	66	preliminary	preliminary	JJ
cord-335198-qp964238	64	67	reports	report	NNS
cord-335198-qp964238	64	68	of	of	IN
cord-335198-qp964238	64	69	potentially	potentially	RB
cord-335198-qp964238	64	70	positive	positive	JJ
cord-335198-qp964238	64	71	results	result	NNS
cord-335198-qp964238	64	72	in	in	IN
cord-335198-qp964238	64	73	larger	large	JJR
cord-335198-qp964238	64	74	trials	trial	NNS
cord-335198-qp964238	64	75	sponsored	sponsor	VBN
cord-335198-qp964238	64	76	by	by	IN
cord-335198-qp964238	64	77	the	the	DT
cord-335198-qp964238	64	78	remdisivir	remdisivir	NNP
cord-335198-qp964238	64	79	patent	patent	NN
cord-335198-qp964238	64	80	holder	holder	NN
cord-335198-qp964238	64	81	(	(	-LRB-
cord-335198-qp964238	64	82	12	12	CD
cord-335198-qp964238	64	83	)	)	-RRB-
cord-335198-qp964238	64	84	.	.	.
cord-335198-qp964238	65	1	Similar	similar	JJ
cord-335198-qp964238	65	2	stories	story	NNS
cord-335198-qp964238	65	3	abound	abound	VBP
cord-335198-qp964238	65	4	for	for	IN
cord-335198-qp964238	65	5	many	many	JJ
cord-335198-qp964238	65	6	other	other	JJ
cord-335198-qp964238	65	7	therapies	therapy	NNS
cord-335198-qp964238	65	8	being	be	VBG
cord-335198-qp964238	65	9	used	use	VBN
cord-335198-qp964238	65	10	to	to	TO
cord-335198-qp964238	65	11	manage	manage	VB
cord-335198-qp964238	65	12	hospitalized	hospitalize	VBN
cord-335198-qp964238	65	13	patients	patient	NNS
cord-335198-qp964238	65	14	with	with	IN
cord-335198-qp964238	65	15	more	more	RBR
cord-335198-qp964238	65	16	severe	severe	JJ
cord-335198-qp964238	65	17	COVID19	COVID19	NNP
cord-335198-qp964238	65	18	related	related	JJ
cord-335198-qp964238	65	19	illness	illness	NN
cord-335198-qp964238	65	20	including	include	VBG
cord-335198-qp964238	65	21	various	various	JJ
cord-335198-qp964238	65	22	respiratory	respiratory	JJ
cord-335198-qp964238	65	23	support	support	NN
cord-335198-qp964238	65	24	strategies	strategy	NNS
cord-335198-qp964238	65	25	and	and	CC
cord-335198-qp964238	65	26	their	-PRON-	PRP$
cord-335198-qp964238	65	27	combinations	combination	NNS
cord-335198-qp964238	65	28	,	,	,
cord-335198-qp964238	65	29	a	a	DT
cord-335198-qp964238	65	30	range	range	NN
cord-335198-qp964238	65	31	of	of	IN
cord-335198-qp964238	65	32	anticoagulation	anticoagulation	NN
cord-335198-qp964238	65	33	protocols	protocol	NNS
cord-335198-qp964238	65	34	,	,	,
cord-335198-qp964238	65	35	novel	novel	JJ
cord-335198-qp964238	65	36	immunotherapeutic	immunotherapeutic	JJ
cord-335198-qp964238	65	37	agents	agent	NNS
cord-335198-qp964238	65	38	including	include	VBG
cord-335198-qp964238	65	39	the	the	DT
cord-335198-qp964238	65	40	anti	anti	JJ
cord-335198-qp964238	65	41	-	-	JJ
cord-335198-qp964238	65	42	IL6	il6	JJ
cord-335198-qp964238	65	43	receptor	receptor	NN
cord-335198-qp964238	65	44	monoclonal	monoclonal	JJ
cord-335198-qp964238	65	45	antibody	antibody	NN
cord-335198-qp964238	65	46	tocilizumab	tocilizumab	NNP
cord-335198-qp964238	65	47	,	,	,
cord-335198-qp964238	65	48	and	and	CC
cord-335198-qp964238	65	49	various	various	JJ
cord-335198-qp964238	65	50	combination	combination	NN
cord-335198-qp964238	65	51	strategies	strategy	NNS
cord-335198-qp964238	65	52	and	and	CC
cord-335198-qp964238	65	53	therapies	therapy	NNS
cord-335198-qp964238	65	54	(	(	-LRB-
cord-335198-qp964238	65	55	13	13	CD
cord-335198-qp964238	65	56	)	)	-RRB-
cord-335198-qp964238	65	57	(	(	-LRB-
cord-335198-qp964238	65	58	14	14	CD
cord-335198-qp964238	65	59	)	)	-RRB-
cord-335198-qp964238	65	60	(	(	-LRB-
cord-335198-qp964238	65	61	15	15	CD
cord-335198-qp964238	65	62	)	)	-RRB-
cord-335198-qp964238	65	63	(	(	-LRB-
cord-335198-qp964238	65	64	16	16	CD
cord-335198-qp964238	65	65	)	)	-RRB-
cord-335198-qp964238	65	66	(	(	-LRB-
cord-335198-qp964238	65	67	17	17	CD
cord-335198-qp964238	65	68	)	)	-RRB-
cord-335198-qp964238	65	69	(	(	-LRB-
cord-335198-qp964238	65	70	18	18	CD
cord-335198-qp964238	65	71	)	)	-RRB-
cord-335198-qp964238	65	72	(	(	-LRB-
cord-335198-qp964238	65	73	19	19	CD
cord-335198-qp964238	65	74	)	)	-RRB-
cord-335198-qp964238	65	75	(	(	-LRB-
cord-335198-qp964238	65	76	20	20	CD
cord-335198-qp964238	65	77	)	)	-RRB-
cord-335198-qp964238	65	78	(	(	-LRB-
cord-335198-qp964238	65	79	21	21	CD
cord-335198-qp964238	65	80	)	)	-RRB-
cord-335198-qp964238	65	81	.	.	.
cord-335198-qp964238	66	1	At	at	IN
cord-335198-qp964238	66	2	the	the	DT
cord-335198-qp964238	66	3	other	other	JJ
cord-335198-qp964238	66	4	end	end	NN
cord-335198-qp964238	66	5	of	of	IN
cord-335198-qp964238	66	6	the	the	DT
cord-335198-qp964238	66	7	spectrum	spectrum	NN
cord-335198-qp964238	66	8	are	be	VBP
cord-335198-qp964238	66	9	the	the	DT
cord-335198-qp964238	66	10	much	much	RB
cord-335198-qp964238	66	11	more	more	RBR
cord-335198-qp964238	66	12	inclusive	inclusive	JJ
cord-335198-qp964238	66	13	,	,	,
cord-335198-qp964238	66	14	simplified	simplified	JJ
cord-335198-qp964238	66	15	and	and	CC
cord-335198-qp964238	66	16	highly	highly	RB
cord-335198-qp964238	66	17	"	"	``
cord-335198-qp964238	66	18	capturing	capture	VBG
cord-335198-qp964238	66	19	"	"	''
cord-335198-qp964238	66	20	RCT	RCT	NNP
cord-335198-qp964238	66	21	approaches	approach	NNS
cord-335198-qp964238	66	22	such	such	JJ
cord-335198-qp964238	66	23	as	as	IN
cord-335198-qp964238	66	24	the	the	DT
cord-335198-qp964238	66	25	WHO	WHO	NNP
cord-335198-qp964238	66	26	Solidarity	Solidarity	NNP
cord-335198-qp964238	66	27	international	international	JJ
cord-335198-qp964238	66	28	clinical	clinical	JJ
cord-335198-qp964238	66	29	trial	trial	NN
cord-335198-qp964238	66	30	across	across	IN
cord-335198-qp964238	66	31	multiple	multiple	JJ
cord-335198-qp964238	66	32	countries	country	NNS
cord-335198-qp964238	66	33	(	(	-LRB-
cord-335198-qp964238	66	34	22	22	CD
cord-335198-qp964238	66	35	)	)	-RRB-
cord-335198-qp964238	66	36	and	and	CC
cord-335198-qp964238	66	37	the	the	DT
cord-335198-qp964238	66	38	Oxford	Oxford	NNP
cord-335198-qp964238	66	39	University	University	NNP
cord-335198-qp964238	66	40	led	lead	VBD
cord-335198-qp964238	66	41	RECOVERY	recovery	NN
cord-335198-qp964238	66	42	trial	trial	NN
cord-335198-qp964238	66	43	in	in	IN
cord-335198-qp964238	66	44	the	the	DT
cord-335198-qp964238	66	45	UK	UK	NNP
cord-335198-qp964238	66	46	(	(	-LRB-
cord-335198-qp964238	66	47	23)both	23)both	CD
cord-335198-qp964238	66	48	designed	design	VBN
cord-335198-qp964238	66	49	to	to	TO
cord-335198-qp964238	66	50	compare	compare	VB
cord-335198-qp964238	66	51	different	different	JJ
cord-335198-qp964238	66	52	treatment	treatment	NN
cord-335198-qp964238	66	53	options	option	NNS
cord-335198-qp964238	66	54	against	against	IN
cord-335198-qp964238	66	55	usual	usual	JJ
cord-335198-qp964238	66	56	of	of	IN
cord-335198-qp964238	66	57	care	care	NN
cord-335198-qp964238	66	58	for	for	IN
cord-335198-qp964238	66	59	as	as	RB
cord-335198-qp964238	66	60	many	many	JJ
cord-335198-qp964238	66	61	hospitalised	hospitalise	VBN
cord-335198-qp964238	66	62	COVID	covid	JJ
cord-335198-qp964238	66	63	patients	patient	NNS
cord-335198-qp964238	66	64	as	as	IN
cord-335198-qp964238	66	65	possible	possible	JJ
cord-335198-qp964238	66	66	within	within	IN
cord-335198-qp964238	66	67	their	-PRON-	PRP$
cord-335198-qp964238	66	68	jurisdictions	jurisdiction	NNS
cord-335198-qp964238	66	69	.	.	.
cord-335198-qp964238	67	1	With	with	IN
cord-335198-qp964238	67	2	large	large	JJ
cord-335198-qp964238	67	3	number	number	NN
cord-335198-qp964238	67	4	of	of	IN
cord-335198-qp964238	67	5	enrolments	enrolment	NNS
cord-335198-qp964238	67	6	helping	help	VBG
cord-335198-qp964238	67	7	to	to	TO
cord-335198-qp964238	67	8	counter	counter	VB
cord-335198-qp964238	67	9	the	the	DT
cord-335198-qp964238	67	10	large	large	JJ
cord-335198-qp964238	67	11	degree	degree	NN
cord-335198-qp964238	67	12	of	of	IN
cord-335198-qp964238	67	13	individual	individual	JJ
cord-335198-qp964238	67	14	case	case	NN
cord-335198-qp964238	67	15	heterogeneity	heterogeneity	NN
cord-335198-qp964238	67	16	that	that	WDT
cord-335198-qp964238	67	17	comes	come	VBZ
cord-335198-qp964238	67	18	with	with	IN
cord-335198-qp964238	67	19	a	a	DT
cord-335198-qp964238	67	20	simplified	simplified	JJ
cord-335198-qp964238	67	21	approach	approach	NN
cord-335198-qp964238	67	22	,	,	,
cord-335198-qp964238	67	23	the	the	DT
cord-335198-qp964238	67	24	Solidarity	Solidarity	NNP
cord-335198-qp964238	67	25	Trial	Trial	NNP
cord-335198-qp964238	67	26	's	's	POS
cord-335198-qp964238	67	27	international	international	JJ
cord-335198-qp964238	67	28	steering	steering	NN
cord-335198-qp964238	67	29	committee	committee	NNP
cord-335198-qp964238	67	30	discontinued	discontinue	VBD
cord-335198-qp964238	67	31	the	the	DT
cord-335198-qp964238	67	32	trial	trial	NN
cord-335198-qp964238	67	33	's	's	POS
cord-335198-qp964238	67	34	hydroxychloroquine	hydroxychloroquine	NN
cord-335198-qp964238	67	35	and	and	CC
cord-335198-qp964238	67	36	lopinavir	lopinavir	NNP
cord-335198-qp964238	67	37	/	/	SYM
cord-335198-qp964238	67	38	ritonavir	ritonavir	NNP
cord-335198-qp964238	67	39	arms	arm	NNS
cord-335198-qp964238	67	40	in	in	IN
cord-335198-qp964238	67	41	early	early	JJ
cord-335198-qp964238	67	42	July	July	NNP
cord-335198-qp964238	67	43	2020	2020	CD
cord-335198-qp964238	67	44	as	as	IN
cord-335198-qp964238	67	45	interim	interim	JJ
cord-335198-qp964238	67	46	trial	trial	NN
cord-335198-qp964238	67	47	results	result	NNS
cord-335198-qp964238	67	48	for	for	IN
cord-335198-qp964238	67	49	both	both	PDT
cord-335198-qp964238	67	50	these	these	DT
cord-335198-qp964238	67	51	treatment	treatment	NN
cord-335198-qp964238	67	52	arms	arm	NNS
cord-335198-qp964238	67	53	showed	show	VBD
cord-335198-qp964238	67	54	little	little	JJ
cord-335198-qp964238	67	55	or	or	CC
cord-335198-qp964238	67	56	no	no	DT
cord-335198-qp964238	67	57	reduction	reduction	NN
cord-335198-qp964238	67	58	in	in	IN
cord-335198-qp964238	67	59	the	the	DT
cord-335198-qp964238	67	60	mortality	mortality	NN
cord-335198-qp964238	67	61	of	of	IN
cord-335198-qp964238	67	62	hospitalised	hospitalise	VBN
cord-335198-qp964238	67	63	COVID19	COVID19	NNP
cord-335198-qp964238	67	64	patients	patient	NNS
cord-335198-qp964238	67	65	(	(	-LRB-
cord-335198-qp964238	67	66	22	22	CD
cord-335198-qp964238	67	67	)	)	-RRB-
cord-335198-qp964238	67	68	.	.	.
cord-335198-qp964238	68	1	The	the	DT
cord-335198-qp964238	68	2	large	large	JJ
cord-335198-qp964238	68	3	RECOVERY	recovery	NN
cord-335198-qp964238	68	4	trial	trial	NN
cord-335198-qp964238	68	5	in	in	IN
cord-335198-qp964238	68	6	the	the	DT
cord-335198-qp964238	68	7	UK	UK	NNP
cord-335198-qp964238	68	8	(	(	-LRB-
cord-335198-qp964238	68	9	n	n	NN
cord-335198-qp964238	68	10	>	>	XX
cord-335198-qp964238	68	11	11,800	11,800	CD
cord-335198-qp964238	68	12	as	as	IN
cord-335198-qp964238	68	13	of	of	IN
cord-335198-qp964238	68	14	29	29	CD
cord-335198-qp964238	68	15	th	th	CD
cord-335198-qp964238	68	16	June	June	NNP
cord-335198-qp964238	68	17	2020	2020	CD
cord-335198-qp964238	68	18	)	)	-RRB-
cord-335198-qp964238	68	19	almost	almost	RB
cord-335198-qp964238	68	20	simultaneously	simultaneously	RB
cord-335198-qp964238	68	21	confirmed	confirm	VBD
cord-335198-qp964238	68	22	these	these	DT
cord-335198-qp964238	68	23	findings	finding	NNS
cord-335198-qp964238	68	24	for	for	IN
cord-335198-qp964238	68	25	both	both	CC
cord-335198-qp964238	68	26	hydroxychloroquine	hydroxychloroquine	NNP
cord-335198-qp964238	68	27	and	and	CC
cord-335198-qp964238	68	28	lopinavir	lopinavir	NNP
cord-335198-qp964238	68	29	/	/	SYM
cord-335198-qp964238	68	30	ritonavir	ritonavir	NNS
cord-335198-qp964238	68	31	,	,	,
cord-335198-qp964238	68	32	and	and	CC
cord-335198-qp964238	68	33	by	by	IN
cord-335198-qp964238	68	34	contrast	contrast	NN
cord-335198-qp964238	68	35	,	,	,
cord-335198-qp964238	68	36	revealed	reveal	VBD
cord-335198-qp964238	68	37	that	that	IN
cord-335198-qp964238	68	38	low	low	JJ
cord-335198-qp964238	68	39	dose	dose	NN
cord-335198-qp964238	68	40	Dexamethasone	Dexamethasone	NNP
cord-335198-qp964238	68	41	(	(	-LRB-
cord-335198-qp964238	68	42	6	6	CD
cord-335198-qp964238	68	43	mg	mg	NN
cord-335198-qp964238	68	44	given	give	VBN
cord-335198-qp964238	68	45	once	once	RB
cord-335198-qp964238	68	46	daily	daily	RB
cord-335198-qp964238	68	47	for	for	IN
cord-335198-qp964238	68	48	up	up	IN
cord-335198-qp964238	68	49	to	to	TO
cord-335198-qp964238	68	50	ten	ten	CD
cord-335198-qp964238	68	51	days	day	NNS
cord-335198-qp964238	68	52	)	)	-RRB-
cord-335198-qp964238	68	53	reduces	reduce	VBZ
cord-335198-qp964238	68	54	the	the	DT
cord-335198-qp964238	68	55	risk	risk	NN
cord-335198-qp964238	68	56	of	of	IN
cord-335198-qp964238	68	57	death	death	NN
cord-335198-qp964238	68	58	by	by	IN
cord-335198-qp964238	68	59	about	about	RB
cord-335198-qp964238	68	60	one	one	CD
cord-335198-qp964238	68	61	-	-	HYPH
cord-335198-qp964238	68	62	third	third	NN
cord-335198-qp964238	68	63	among	among	IN
cord-335198-qp964238	68	64	patients	patient	NNS
cord-335198-qp964238	68	65	receiving	receive	VBG
cord-335198-qp964238	68	66	ventilation	ventilation	NN
cord-335198-qp964238	68	67	and	and	CC
cord-335198-qp964238	68	68	by	by	IN
cord-335198-qp964238	68	69	one	one	CD
cord-335198-qp964238	68	70	-	-	HYPH
cord-335198-qp964238	68	71	fifth	fifth	NN
cord-335198-qp964238	68	72	in	in	IN
cord-335198-qp964238	68	73	those	those	DT
cord-335198-qp964238	68	74	requiring	require	VBG
cord-335198-qp964238	68	75	oxygen	oxygen	NN
cord-335198-qp964238	68	76	alone	alone	JJ
cord-335198-qp964238	68	77	(	(	-LRB-
cord-335198-qp964238	68	78	with	with	IN
cord-335198-qp964238	68	79	no	no	DT
cord-335198-qp964238	68	80	benefit	benefit	NN
cord-335198-qp964238	68	81	among	among	IN
cord-335198-qp964238	68	82	those	those	DT
cord-335198-qp964238	68	83	not	not	RB
cord-335198-qp964238	68	84	requiring	require	VBG
cord-335198-qp964238	68	85	ventilatory	ventilatory	JJ
cord-335198-qp964238	68	86	support	support	NN
cord-335198-qp964238	68	87	)	)	-RRB-
cord-335198-qp964238	69	1	(	(	-LRB-
cord-335198-qp964238	69	2	23	23	CD
cord-335198-qp964238	69	3	,	,	,
cord-335198-qp964238	69	4	24	24	CD
cord-335198-qp964238	69	5	)	)	-RRB-
cord-335198-qp964238	69	6	.	.	.
cord-335198-qp964238	70	1	Other	other	JJ
cord-335198-qp964238	70	2	treatment	treatment	NN
cord-335198-qp964238	70	3	arms	arm	NNS
cord-335198-qp964238	70	4	in	in	IN
cord-335198-qp964238	70	5	the	the	DT
cord-335198-qp964238	70	6	RECOVERY	recovery	NN
cord-335198-qp964238	70	7	trial	trial	NN
cord-335198-qp964238	70	8	include	include	VBP
cord-335198-qp964238	70	9	Azithromycin	Azithromycin	NNP
cord-335198-qp964238	70	10	,	,	,
cord-335198-qp964238	70	11	Tocilizumab	tocilizumab	JJ
cord-335198-qp964238	70	12	and	and	CC
cord-335198-qp964238	70	13	convalescent	convalescent	JJ
cord-335198-qp964238	70	14	plasma	plasma	NN
cord-335198-qp964238	70	15	(	(	-LRB-
cord-335198-qp964238	70	16	23	23	CD
cord-335198-qp964238	70	17	)	)	-RRB-
cord-335198-qp964238	70	18	.	.	.
cord-335198-qp964238	71	1	A	a	DT
cord-335198-qp964238	71	2	closer	close	JJR
cord-335198-qp964238	71	3	look	look	NN
cord-335198-qp964238	71	4	at	at	IN
cord-335198-qp964238	71	5	what	what	WP
cord-335198-qp964238	71	6	transpired	transpire	VBD
cord-335198-qp964238	71	7	during	during	IN
cord-335198-qp964238	71	8	the	the	DT
cord-335198-qp964238	71	9	2009	2009	CD
cord-335198-qp964238	71	10	Influenza	Influenza	NNP
cord-335198-qp964238	71	11	A	A	NNP
cord-335198-qp964238	71	12	H1N1(09	H1N1(09	NNP
cord-335198-qp964238	71	13	)	)	-RRB-
cord-335198-qp964238	71	14	pandemic	pandemic	NN
cord-335198-qp964238	72	1	-our	-our	:
cord-335198-qp964238	72	2	most	most	RBS
cord-335198-qp964238	72	3	recent	recent	JJ
cord-335198-qp964238	72	4	pandemic	pandemic	NN
cord-335198-qp964238	72	5	prior	prior	RB
cord-335198-qp964238	72	6	to	to	IN
cord-335198-qp964238	72	7	COVID19	COVID19	NNP
cord-335198-qp964238	72	8	,	,	,
cord-335198-qp964238	72	9	is	be	VBZ
cord-335198-qp964238	72	10	very	very	RB
cord-335198-qp964238	72	11	salient	salient	JJ
cord-335198-qp964238	72	12	.	.	.
cord-335198-qp964238	73	1	Patients	patient	NNS
cord-335198-qp964238	73	2	were	be	VBD
cord-335198-qp964238	73	3	frequently	frequently	RB
cord-335198-qp964238	73	4	treated	treat	VBN
cord-335198-qp964238	73	5	for	for	IN
cord-335198-qp964238	73	6	pandemic	pandemic	NN
cord-335198-qp964238	73	7	influenza	influenza	NN
cord-335198-qp964238	73	8	viral	viral	JJ
cord-335198-qp964238	73	9	pneumonia	pneumonia	NN
cord-335198-qp964238	73	10	with	with	IN
cord-335198-qp964238	73	11	drugs	drug	NNS
cord-335198-qp964238	73	12	not	not	RB
cord-335198-qp964238	73	13	specifically	specifically	RB
cord-335198-qp964238	73	14	registered	register	VBN
cord-335198-qp964238	73	15	for	for	IN
cord-335198-qp964238	73	16	this	this	DT
cord-335198-qp964238	73	17	indication	indication	NN
cord-335198-qp964238	73	18	and	and	CC
cord-335198-qp964238	73	19	rarely	rarely	RB
cord-335198-qp964238	73	20	under	under	IN
cord-335198-qp964238	73	21	circumstances	circumstance	NNS
cord-335198-qp964238	73	22	of	of	IN
cord-335198-qp964238	73	23	high	high	JJ
cord-335198-qp964238	73	24	-	-	HYPH
cord-335198-qp964238	73	25	quality	quality	NN
cord-335198-qp964238	73	26	data	datum	NNS
cord-335198-qp964238	73	27	capture	capture	NN
cord-335198-qp964238	73	28	.	.	.
cord-335198-qp964238	74	1	This	this	DT
cord-335198-qp964238	74	2	resulted	result	VBD
cord-335198-qp964238	74	3	in	in	IN
cord-335198-qp964238	74	4	experimental	experimental	JJ
cord-335198-qp964238	74	5	drugs	drug	NNS
cord-335198-qp964238	74	6	being	be	VBG
cord-335198-qp964238	74	7	used	use	VBN
cord-335198-qp964238	74	8	largely	largely	RB
cord-335198-qp964238	74	9	on	on	IN
cord-335198-qp964238	74	10	compassionate	compassionate	JJ
cord-335198-qp964238	74	11	grounds	ground	NNS
cord-335198-qp964238	74	12	with	with	IN
cord-335198-qp964238	74	13	no	no	DT
cord-335198-qp964238	74	14	real	real	JJ
cord-335198-qp964238	74	15	improvement	improvement	NN
cord-335198-qp964238	74	16	in	in	IN
cord-335198-qp964238	74	17	our	-PRON-	PRP$
cord-335198-qp964238	74	18	understanding	understanding	NN
cord-335198-qp964238	74	19	of	of	IN
cord-335198-qp964238	74	20	the	the	DT
cord-335198-qp964238	74	21	potential	potential	JJ
cord-335198-qp964238	74	22	benefits	benefit	NNS
cord-335198-qp964238	74	23	and	and	CC
cord-335198-qp964238	74	24	harms	harm	NNS
cord-335198-qp964238	74	25	of	of	IN
cord-335198-qp964238	74	26	specific	specific	JJ
cord-335198-qp964238	74	27	treatments	treatment	NNS
cord-335198-qp964238	74	28	.	.	.
cord-335198-qp964238	75	1	However	however	RB
cord-335198-qp964238	75	2	,	,	,
cord-335198-qp964238	75	3	further	further	JJ
cord-335198-qp964238	75	4	reflections	reflection	NNS
cord-335198-qp964238	75	5	on	on	IN
cord-335198-qp964238	75	6	the	the	DT
cord-335198-qp964238	75	7	above	above	JJ
cord-335198-qp964238	75	8	outcomes	outcome	NNS
cord-335198-qp964238	75	9	led	lead	VBD
cord-335198-qp964238	75	10	some	some	DT
cord-335198-qp964238	75	11	clinician	clinician	NN
cord-335198-qp964238	75	12	-	-	:
cord-335198-qp964238	75	13	researchers	researcher	NNS
cord-335198-qp964238	75	14	to	to	IN
cord-335198-qp964238	75	15	a	a	DT
cord-335198-qp964238	75	16	unifying	unify	VBG
cord-335198-qp964238	75	17	multicentre	multicentre	NNP
cord-335198-qp964238	75	18	embrace	embrace	NN
cord-335198-qp964238	75	19	of	of	IN
cord-335198-qp964238	75	20	master	master	NN
cord-335198-qp964238	75	21	protocols	protocol	NNS
cord-335198-qp964238	75	22	,	,	,
cord-335198-qp964238	75	23	adaptive	adaptive	JJ
cord-335198-qp964238	75	24	trial	trial	NN
cord-335198-qp964238	75	25	platforms	platform	NNS
cord-335198-qp964238	75	26	and	and	CC
cord-335198-qp964238	75	27	overarching	overarching	JJ
cord-335198-qp964238	75	28	statistical	statistical	JJ
cord-335198-qp964238	75	29	plans	plan	NNS
cord-335198-qp964238	75	30	.	.	.
cord-335198-qp964238	76	1	These	these	DT
cord-335198-qp964238	76	2	are	be	VBP
cord-335198-qp964238	76	3	designed	design	VBN
cord-335198-qp964238	76	4	to	to	TO
cord-335198-qp964238	76	5	build	build	VB
cord-335198-qp964238	76	6	operational	operational	JJ
cord-335198-qp964238	76	7	"	"	``
cord-335198-qp964238	76	8	checks	check	NNS
cord-335198-qp964238	76	9	and	and	CC
cord-335198-qp964238	76	10	balances	balance	NNS
cord-335198-qp964238	76	11	"	"	''
cord-335198-qp964238	76	12	into	into	IN
cord-335198-qp964238	76	13	a	a	DT
cord-335198-qp964238	76	14	modular	modular	JJ
cord-335198-qp964238	76	15	study	study	NN
cord-335198-qp964238	76	16	framework	framework	NN
cord-335198-qp964238	76	17	that	that	WDT
cord-335198-qp964238	76	18	remains	remain	VBZ
cord-335198-qp964238	76	19	congruent	congruent	JJ
cord-335198-qp964238	76	20	across	across	IN
cord-335198-qp964238	76	21	time	time	NN
cord-335198-qp964238	76	22	and	and	CC
cord-335198-qp964238	76	23	space	space	NN
cord-335198-qp964238	76	24	and	and	CC
cord-335198-qp964238	76	25	promotes	promote	VBZ
cord-335198-qp964238	76	26	a	a	DT
cord-335198-qp964238	76	27	culture	culture	NN
cord-335198-qp964238	76	28	of	of	IN
cord-335198-qp964238	76	29	learning	learn	VBG
cord-335198-qp964238	76	30	as	as	IN
cord-335198-qp964238	76	31	you	-PRON-	PRP
cord-335198-qp964238	76	32	go	go	VBP
cord-335198-qp964238	76	33	.	.	.
cord-335198-qp964238	77	1	Hence	hence	RB
cord-335198-qp964238	77	2	,	,	,
cord-335198-qp964238	77	3	although	although	IN
cord-335198-qp964238	77	4	REMAP	REMAP	NNP
cord-335198-qp964238	77	5	-	-	HYPH
cord-335198-qp964238	77	6	CAP	CAP	NNP
cord-335198-qp964238	77	7	was	be	VBD
cord-335198-qp964238	77	8	originally	originally	RB
cord-335198-qp964238	77	9	designed	design	VBN
cord-335198-qp964238	77	10	to	to	TO
cord-335198-qp964238	77	11	study	study	VB
cord-335198-qp964238	77	12	severe	severe	JJ
cord-335198-qp964238	77	13	pneumonia	pneumonia	NN
cord-335198-qp964238	77	14	requiring	require	VBG
cord-335198-qp964238	77	15	ICU	ICU	NNP
cord-335198-qp964238	77	16	management	management	NN
cord-335198-qp964238	77	17	in	in	IN
cord-335198-qp964238	77	18	over	over	IN
cord-335198-qp964238	77	19	160	160	CD
cord-335198-qp964238	77	20	sites	site	NNS
cord-335198-qp964238	77	21	across	across	IN
cord-335198-qp964238	77	22	many	many	JJ
cord-335198-qp964238	77	23	countries	country	NNS
cord-335198-qp964238	77	24	,	,	,
cord-335198-qp964238	77	25	it	-PRON-	PRP
cord-335198-qp964238	77	26	was	be	VBD
cord-335198-qp964238	77	27	quickly	quickly	RB
cord-335198-qp964238	77	28	adapted	adapt	VBN
cord-335198-qp964238	77	29	after	after	IN
cord-335198-qp964238	78	1	the	the	DT
cord-335198-qp964238	78	2	HIN1(09	HIN1(09	NNP
cord-335198-qp964238	78	3	)	)	-RRB-
cord-335198-qp964238	78	4	pandemic	pandemic	NN
cord-335198-qp964238	78	5	be	be	VB
cord-335198-qp964238	78	6	pandemic	pandemic	NN
cord-335198-qp964238	78	7	influenza	influenza	NN
cord-335198-qp964238	78	8	ready	ready	JJ
cord-335198-qp964238	78	9	making	make	VBG
cord-335198-qp964238	78	10	it	-PRON-	PRP
cord-335198-qp964238	78	11	relatively	relatively	RB
cord-335198-qp964238	78	12	easy	easy	JJ
cord-335198-qp964238	78	13	to	to	TO
cord-335198-qp964238	78	14	switch	switch	VB
cord-335198-qp964238	78	15	its	-PRON-	PRP$
cord-335198-qp964238	78	16	focus	focus	NN
cord-335198-qp964238	78	17	to	to	IN
cord-335198-qp964238	78	18	the	the	DT
cord-335198-qp964238	78	19	current	current	JJ
cord-335198-qp964238	78	20	COVID19	COVID19	NNP
cord-335198-qp964238	78	21	pandemic	pandemic	NN
cord-335198-qp964238	78	22	.	.	.
cord-335198-qp964238	79	1	A	a	DT
cord-335198-qp964238	79	2	key	key	JJ
cord-335198-qp964238	79	3	feature	feature	NN
cord-335198-qp964238	79	4	of	of	IN
cord-335198-qp964238	79	5	adaptive	adaptive	JJ
cord-335198-qp964238	79	6	trial	trial	NN
cord-335198-qp964238	79	7	design	design	NN
cord-335198-qp964238	79	8	is	be	VBZ
cord-335198-qp964238	79	9	that	that	IN
cord-335198-qp964238	79	10	researchers	researcher	NNS
cord-335198-qp964238	79	11	are	be	VBP
cord-335198-qp964238	79	12	required	require	VBN
cord-335198-qp964238	79	13	to	to	TO
cord-335198-qp964238	79	14	add	add	VB
cord-335198-qp964238	79	15	and	and	CC
cord-335198-qp964238	79	16	remove	remove	VB
cord-335198-qp964238	79	17	treatment	treatment	NN
cord-335198-qp964238	79	18	groups	group	NNS
cord-335198-qp964238	79	19	as	as	IN
cord-335198-qp964238	79	20	the	the	DT
cord-335198-qp964238	79	21	trial	trial	NN
cord-335198-qp964238	79	22	is	be	VBZ
cord-335198-qp964238	79	23	running	run	VBG
cord-335198-qp964238	79	24	in	in	IN
cord-335198-qp964238	79	25	order	order	NN
cord-335198-qp964238	79	26	to	to	TO
cord-335198-qp964238	79	27	minimize	minimize	VB
cord-335198-qp964238	79	28	the	the	DT
cord-335198-qp964238	79	29	diluting	dilute	VBG
cord-335198-qp964238	79	30	effects	effect	NNS
cord-335198-qp964238	79	31	of	of	IN
cord-335198-qp964238	79	32	futile	futile	JJ
cord-335198-qp964238	79	33	treatments	treatment	NNS
cord-335198-qp964238	79	34	and	and	CC
cord-335198-qp964238	79	35	maximize	maximize	VB
cord-335198-qp964238	79	36	the	the	DT
cord-335198-qp964238	79	37	signal	signal	NN
cord-335198-qp964238	79	38	to	to	IN
cord-335198-qp964238	79	39	noise	noise	NN
cord-335198-qp964238	79	40	ratio	ratio	NN
cord-335198-qp964238	79	41	of	of	IN
cord-335198-qp964238	79	42	more	more	RBR
cord-335198-qp964238	79	43	promising	promising	JJ
cord-335198-qp964238	79	44	treatments	treatment	NNS
cord-335198-qp964238	79	45	according	accord	VBG
cord-335198-qp964238	79	46	to	to	IN
cord-335198-qp964238	79	47	certain	certain	JJ
cord-335198-qp964238	79	48	trigger	trigger	NN
cord-335198-qp964238	79	49	thresholds	threshold	NNS
cord-335198-qp964238	79	50	.	.	.
cord-335198-qp964238	80	1	And	and	CC
cord-335198-qp964238	80	2	so	so	RB
cord-335198-qp964238	80	3	,	,	,
cord-335198-qp964238	80	4	no	no	DT
cord-335198-qp964238	80	5	algorithmic	algorithmic	JJ
cord-335198-qp964238	80	6	approach	approach	NN
cord-335198-qp964238	80	7	can	can	MD
cord-335198-qp964238	80	8	completely	completely	RB
cord-335198-qp964238	80	9	substitute	substitute	VB
cord-335198-qp964238	80	10	for	for	IN
cord-335198-qp964238	80	11	imaginatively	imaginatively	RB
cord-335198-qp964238	80	12	insightful	insightful	JJ
cord-335198-qp964238	80	13	,	,	,
cord-335198-qp964238	80	14	thoughtfully	thoughtfully	RB
cord-335198-qp964238	80	15	rational	rational	JJ
cord-335198-qp964238	80	16	and	and	CC
cord-335198-qp964238	80	17	well	well	RB
cord-335198-qp964238	80	18	-	-	HYPH
cord-335198-qp964238	80	19	equilibrated	equilibrate	VBN
cord-335198-qp964238	80	20	ethical	ethical	JJ
cord-335198-qp964238	80	21	thinking	thinking	NN
cord-335198-qp964238	80	22	.	.	.
cord-335198-qp964238	81	1	Additionally	additionally	RB
cord-335198-qp964238	81	2	,	,	,
cord-335198-qp964238	81	3	there	there	EX
cord-335198-qp964238	81	4	is	be	VBZ
cord-335198-qp964238	81	5	the	the	DT
cord-335198-qp964238	81	6	increasing	increase	VBG
cord-335198-qp964238	81	7	appreciation	appreciation	NN
cord-335198-qp964238	81	8	that	that	IN
cord-335198-qp964238	81	9	although	although	IN
cord-335198-qp964238	81	10	adaptive	adaptive	JJ
cord-335198-qp964238	81	11	trial	trial	NN
cord-335198-qp964238	81	12	designs	design	NNS
cord-335198-qp964238	81	13	for	for	IN
cord-335198-qp964238	81	14	treatments	treatment	NNS
cord-335198-qp964238	81	15	is	be	VBZ
cord-335198-qp964238	81	16	a	a	DT
cord-335198-qp964238	81	17	great	great	JJ
cord-335198-qp964238	81	18	start	start	NN
cord-335198-qp964238	81	19	,	,	,
cord-335198-qp964238	81	20	they	-PRON-	PRP
cord-335198-qp964238	81	21	may	may	MD
cord-335198-qp964238	81	22	not	not	RB
cord-335198-qp964238	81	23	go	go	VB
cord-335198-qp964238	81	24	far	far	RB
cord-335198-qp964238	81	25	enough	enough	RB
cord-335198-qp964238	81	26	.	.	.
cord-335198-qp964238	82	1	Given	give	VBN
cord-335198-qp964238	82	2	the	the	DT
cord-335198-qp964238	82	3	extensive	extensive	JJ
cord-335198-qp964238	82	4	variation	variation	NN
cord-335198-qp964238	82	5	in	in	IN
cord-335198-qp964238	82	6	clinical	clinical	JJ
cord-335198-qp964238	82	7	outcomes	outcome	NNS
cord-335198-qp964238	82	8	with	with	IN
cord-335198-qp964238	82	9	COVID19	COVID19	NNP
cord-335198-qp964238	82	10	infection	infection	NN
cord-335198-qp964238	82	11	in	in	IN
cord-335198-qp964238	82	12	the	the	DT
cord-335198-qp964238	82	13	population	population	NN
cord-335198-qp964238	82	14	at	at	IN
cord-335198-qp964238	82	15	large	large	JJ
cord-335198-qp964238	82	16	,	,	,
cord-335198-qp964238	82	17	we	-PRON-	PRP
cord-335198-qp964238	82	18	may	may	MD
cord-335198-qp964238	82	19	well	well	RB
cord-335198-qp964238	82	20	need	need	VB
cord-335198-qp964238	82	21	to	to	TO
cord-335198-qp964238	82	22	also	also	RB
cord-335198-qp964238	82	23	integrate	integrate	VB
cord-335198-qp964238	82	24	some	some	DT
cord-335198-qp964238	82	25	well	well	RB
cord-335198-qp964238	82	26	-	-	HYPH
cord-335198-qp964238	82	27	chosen	choose	VBN
cord-335198-qp964238	82	28	deeper	deep	JJR
cord-335198-qp964238	82	29	phenotype	phenotype	NN
cord-335198-qp964238	82	30	and	and	CC
cord-335198-qp964238	82	31	genotype	genotype	NN
cord-335198-qp964238	82	32	factors	factor	NNS
cord-335198-qp964238	82	33	into	into	IN
cord-335198-qp964238	82	34	our	-PRON-	PRP$
cord-335198-qp964238	82	35	adaptive	adaptive	JJ
cord-335198-qp964238	82	36	trial	trial	NN
cord-335198-qp964238	82	37	designs	design	NNS
cord-335198-qp964238	82	38	and	and	CC
cord-335198-qp964238	82	39	analyses	analysis	NNS
cord-335198-qp964238	82	40	.	.	.
cord-335198-qp964238	83	1	The	the	DT
cord-335198-qp964238	83	2	benefits	benefit	NNS
cord-335198-qp964238	83	3	of	of	IN
cord-335198-qp964238	83	4	any	any	DT
cord-335198-qp964238	83	5	such	such	JJ
cord-335198-qp964238	83	6	extended	extended	JJ
cord-335198-qp964238	83	7	approach	approach	NN
cord-335198-qp964238	83	8	will	will	MD
cord-335198-qp964238	83	9	of	of	IN
cord-335198-qp964238	83	10	course	course	NN
cord-335198-qp964238	83	11	need	need	VB
cord-335198-qp964238	83	12	to	to	TO
cord-335198-qp964238	83	13	be	be	VB
cord-335198-qp964238	83	14	weighed	weigh	VBN
cord-335198-qp964238	83	15	up	up	RP
cord-335198-qp964238	83	16	against	against	IN
cord-335198-qp964238	83	17	the	the	DT
cord-335198-qp964238	83	18	potential	potential	NN
cord-335198-qp964238	83	19	for	for	IN
cord-335198-qp964238	83	20	greatly	greatly	RB
cord-335198-qp964238	83	21	increasing	increase	VBG
cord-335198-qp964238	83	22	the	the	DT
cord-335198-qp964238	83	23	logistic	logistic	JJ
cord-335198-qp964238	83	24	complexity	complexity	NN
cord-335198-qp964238	83	25	of	of	IN
cord-335198-qp964238	83	26	adaptive	adaptive	JJ
cord-335198-qp964238	83	27	trials	trial	NNS
cord-335198-qp964238	83	28	beyond	beyond	IN
cord-335198-qp964238	83	29	what	what	WP
cord-335198-qp964238	83	30	is	be	VBZ
cord-335198-qp964238	83	31	practically	practically	RB
cord-335198-qp964238	83	32	manageable	manageable	JJ
cord-335198-qp964238	83	33	even	even	RB
cord-335198-qp964238	83	34	with	with	IN
cord-335198-qp964238	83	35	the	the	DT
cord-335198-qp964238	83	36	potential	potential	JJ
cord-335198-qp964238	83	37	help	help	NN
cord-335198-qp964238	83	38	of	of	IN
cord-335198-qp964238	83	39	enhanced	enhance	VBN
cord-335198-qp964238	83	40	machine	machine	NN
cord-335198-qp964238	83	41	learning	learn	VBG
cord-335198-qp964238	83	42	protocols	protocol	NNS
cord-335198-qp964238	83	43	,	,	,
cord-335198-qp964238	83	44	and	and	CC
cord-335198-qp964238	83	45	of	of	IN
cord-335198-qp964238	83	46	course	course	NN
cord-335198-qp964238	83	47	the	the	DT
cord-335198-qp964238	83	48	inexorable	inexorable	JJ
cord-335198-qp964238	83	49	law	law	NN
cord-335198-qp964238	83	50	of	of	IN
cord-335198-qp964238	83	51	diminishing	diminish	VBG
cord-335198-qp964238	83	52	returns	return	NNS
cord-335198-qp964238	83	53	.	.	.
cord-335198-qp964238	84	1	As	as	IN
cord-335198-qp964238	84	2	always	always	RB
cord-335198-qp964238	84	3	,	,	,
cord-335198-qp964238	84	4	appropriately	appropriately	RB
cord-335198-qp964238	84	5	managing	manage	VBG
cord-335198-qp964238	84	6	individual	individual	JJ
cord-335198-qp964238	84	7	patient	patient	NN
cord-335198-qp964238	84	8	case	case	NN
cord-335198-qp964238	84	9	priorities	priority	NNS
cord-335198-qp964238	84	10	is	be	VBZ
cord-335198-qp964238	84	11	a	a	DT
cord-335198-qp964238	84	12	central	central	JJ
cord-335198-qp964238	84	13	pillar	pillar	NN
cord-335198-qp964238	84	14	of	of	IN
cord-335198-qp964238	84	15	ethical	ethical	JJ
cord-335198-qp964238	84	16	clinical	clinical	JJ
cord-335198-qp964238	84	17	practice	practice	NN
cord-335198-qp964238	84	18	.	.	.
cord-335198-qp964238	85	1	This	this	DT
cord-335198-qp964238	85	2	is	be	VBZ
cord-335198-qp964238	85	3	true	true	JJ
cord-335198-qp964238	85	4	both	both	DT
cord-335198-qp964238	85	5	within	within	IN
cord-335198-qp964238	85	6	an	an	DT
cord-335198-qp964238	85	7	exploratory	exploratory	JJ
cord-335198-qp964238	85	8	n	n	NN
cord-335198-qp964238	85	9	of	of	IN
cord-335198-qp964238	85	10	1	1	CD
cord-335198-qp964238	85	11	framework	framework	NN
cord-335198-qp964238	85	12	and	and	CC
cord-335198-qp964238	85	13	in	in	IN
cord-335198-qp964238	85	14	exploiting	exploit	VBG
cord-335198-qp964238	85	15	n	n	CC
cord-335198-qp964238	85	16	of	of	IN
cord-335198-qp964238	85	17	many	many	JJ
cord-335198-qp964238	85	18	RCTs	rct	NNS
cord-335198-qp964238	85	19	.	.	.
cord-335198-qp964238	86	1	Hence	hence	RB
cord-335198-qp964238	86	2	,	,	,
cord-335198-qp964238	86	3	although	although	IN
cord-335198-qp964238	86	4	the	the	DT
cord-335198-qp964238	86	5	uncontrolled	uncontrolled	JJ
cord-335198-qp964238	86	6	,	,	,
cord-335198-qp964238	86	7	compassionate	compassionate	JJ
cord-335198-qp964238	86	8	use	use	NN
cord-335198-qp964238	86	9	of	of	IN
cord-335198-qp964238	86	10	specific	specific	JJ
cord-335198-qp964238	86	11	off	off	IN
cord-335198-qp964238	86	12	-	-	HYPH
cord-335198-qp964238	86	13	label	label	NN
cord-335198-qp964238	86	14	therapies	therapy	NNS
cord-335198-qp964238	86	15	may	may	MD
cord-335198-qp964238	86	16	be	be	VB
cord-335198-qp964238	86	17	acceptable	acceptable	JJ
cord-335198-qp964238	86	18	in	in	IN
cord-335198-qp964238	86	19	one	one	CD
cord-335198-qp964238	86	20	framework	framework	NN
cord-335198-qp964238	86	21	,	,	,
cord-335198-qp964238	86	22	a	a	DT
cord-335198-qp964238	86	23	completely	completely	RB
cord-335198-qp964238	86	24	different	different	JJ
cord-335198-qp964238	86	25	framework	framework	NN
cord-335198-qp964238	86	26	is	be	VBZ
cord-335198-qp964238	86	27	required	require	VBN
cord-335198-qp964238	86	28	to	to	TO
cord-335198-qp964238	86	29	generate	generate	VB
cord-335198-qp964238	86	30	a	a	DT
cord-335198-qp964238	86	31	quality	quality	NN
cord-335198-qp964238	86	32	evidence	evidence	NN
cord-335198-qp964238	86	33	base	base	NN
cord-335198-qp964238	86	34	for	for	IN
cord-335198-qp964238	86	35	improved	improved	JJ
cord-335198-qp964238	86	36	pandemic	pandemic	NN
cord-335198-qp964238	86	37	management	management	NN
cord-335198-qp964238	86	38	practices	practice	NNS
cord-335198-qp964238	86	39	now	now	RB
cord-335198-qp964238	86	40	and	and	CC
cord-335198-qp964238	86	41	in	in	IN
cord-335198-qp964238	86	42	the	the	DT
cord-335198-qp964238	86	43	future	future	NN
cord-335198-qp964238	86	44	.	.	.
cord-335198-qp964238	87	1	Additionally	additionally	RB
cord-335198-qp964238	87	2	,	,	,
cord-335198-qp964238	87	3	within	within	IN
cord-335198-qp964238	87	4	framework	framework	NN
cord-335198-qp964238	87	5	discussions	discussion	NNS
cord-335198-qp964238	87	6	matching	match	VBG
cord-335198-qp964238	87	7	rights	right	NNS
cord-335198-qp964238	87	8	and	and	CC
cord-335198-qp964238	87	9	responsibilities	responsibility	NNS
cord-335198-qp964238	87	10	is	be	VBZ
cord-335198-qp964238	87	11	generally	generally	RB
cord-335198-qp964238	87	12	much	much	RB
cord-335198-qp964238	87	13	more	more	RBR
cord-335198-qp964238	87	14	comfortable	comfortable	JJ
cord-335198-qp964238	87	15	than	than	IN
cord-335198-qp964238	87	16	between	between	IN
cord-335198-qp964238	87	17	frameworks	framework	NNS
cord-335198-qp964238	87	18	.	.	.
cord-335198-qp964238	88	1	And	and	CC
cord-335198-qp964238	88	2	yet	yet	RB
cord-335198-qp964238	88	3	,	,	,
cord-335198-qp964238	88	4	individuals	individual	NNS
cord-335198-qp964238	88	5	and	and	CC
cord-335198-qp964238	88	6	the	the	DT
cord-335198-qp964238	88	7	society	society	NN
cord-335198-qp964238	88	8	they	-PRON-	PRP
cord-335198-qp964238	88	9	belong	belong	VBP
cord-335198-qp964238	88	10	to	to	IN
cord-335198-qp964238	88	11	are	be	VBP
cord-335198-qp964238	88	12	irrevocably	irrevocably	RB
cord-335198-qp964238	88	13	intertwined	intertwine	VBN
cord-335198-qp964238	88	14	and	and	CC
cord-335198-qp964238	88	15	interdependent	interdependent	JJ
cord-335198-qp964238	88	16	.	.	.
cord-335198-qp964238	89	1	Negotiating	negotiate	VBG
cord-335198-qp964238	89	2	the	the	DT
cord-335198-qp964238	89	3	deep	deep	JJ
cord-335198-qp964238	89	4	chasm	chasm	NN
cord-335198-qp964238	89	5	between	between	IN
cord-335198-qp964238	89	6	frameworks	framework	NNS
cord-335198-qp964238	89	7	is	be	VBZ
cord-335198-qp964238	89	8	a	a	DT
cord-335198-qp964238	89	9	key	key	JJ
cord-335198-qp964238	89	10	challenge	challenge	NN
cord-335198-qp964238	89	11	for	for	IN
cord-335198-qp964238	89	12	treating	treat	VBG
cord-335198-qp964238	89	13	clinicians	clinician	NNS
cord-335198-qp964238	89	14	so	so	IN
cord-335198-qp964238	89	15	that	that	IN
cord-335198-qp964238	89	16	we	-PRON-	PRP
cord-335198-qp964238	89	17	do	do	VBP
cord-335198-qp964238	89	18	n't	not	RB
cord-335198-qp964238	89	19	get	get	VB
cord-335198-qp964238	89	20	lost	lose	VBN
cord-335198-qp964238	89	21	in	in	IN
cord-335198-qp964238	89	22	a	a	DT
cord-335198-qp964238	89	23	multitude	multitude	NN
cord-335198-qp964238	89	24	of	of	IN
cord-335198-qp964238	89	25	poorly	poorly	RB
cord-335198-qp964238	89	26	controlled	control	VBN
cord-335198-qp964238	89	27	studies	study	NNS
cord-335198-qp964238	89	28	but	but	CC
cord-335198-qp964238	89	29	leap	leap	NN
cord-335198-qp964238	89	30	towards	towards	IN
cord-335198-qp964238	89	31	a	a	DT
cord-335198-qp964238	89	32	hierarchy	hierarchy	NN
cord-335198-qp964238	89	33	of	of	IN
cord-335198-qp964238	89	34	larger	large	JJR
cord-335198-qp964238	89	35	clinical	clinical	JJ
cord-335198-qp964238	89	36	trials	trial	NNS
cord-335198-qp964238	89	37	arranged	arrange	VBN
cord-335198-qp964238	89	38	according	accord	VBG
cord-335198-qp964238	89	39	to	to	IN
cord-335198-qp964238	89	40	likelihood	likelihood	NN
cord-335198-qp964238	89	41	of	of	IN
cord-335198-qp964238	89	42	success	success	NN
cord-335198-qp964238	89	43	based	base	VBN
cord-335198-qp964238	89	44	on	on	IN
cord-335198-qp964238	89	45	early	early	JJ
cord-335198-qp964238	89	46	but	but	CC
cord-335198-qp964238	89	47	uncertain	uncertain	JJ
cord-335198-qp964238	89	48	signals	signal	NNS
cord-335198-qp964238	89	49	in	in	IN
cord-335198-qp964238	89	50	smaller	small	JJR
cord-335198-qp964238	89	51	numbers	number	NNS
cord-335198-qp964238	89	52	of	of	IN
cord-335198-qp964238	89	53	patients	patient	NNS
cord-335198-qp964238	89	54	.	.	.
cord-335198-qp964238	90	1	Ethical	ethical	JJ
cord-335198-qp964238	90	2	leadership	leadership	NN
cord-335198-qp964238	90	3	therefore	therefore	RB
cord-335198-qp964238	90	4	requires	require	VBZ
cord-335198-qp964238	90	5	us	-PRON-	PRP
cord-335198-qp964238	90	6	to	to	TO
cord-335198-qp964238	90	7	be	be	VB
cord-335198-qp964238	90	8	agile	agile	JJ
cord-335198-qp964238	90	9	,	,	,
cord-335198-qp964238	90	10	proportionate	proportionate	JJ
cord-335198-qp964238	90	11	and	and	CC
cord-335198-qp964238	90	12	adaptive	adaptive	JJ
cord-335198-qp964238	90	13	in	in	IN
cord-335198-qp964238	90	14	aligning	align	VBG
cord-335198-qp964238	90	15	,	,	,
cord-335198-qp964238	90	16	balancing	balance	VBG
cord-335198-qp964238	90	17	and	and	CC
cord-335198-qp964238	90	18	contextualising	contextualise	VBG
cord-335198-qp964238	90	19	patient	patient	NN
cord-335198-qp964238	90	20	needs	need	VBZ
cord-335198-qp964238	90	21	across	across	IN
cord-335198-qp964238	90	22	many	many	JJ
cord-335198-qp964238	90	23	dimensions	dimension	NNS
cord-335198-qp964238	90	24	both	both	CC
cord-335198-qp964238	90	25	simultaneously	simultaneously	RB
cord-335198-qp964238	90	26	and	and	CC
cord-335198-qp964238	90	27	separately	separately	RB
cord-335198-qp964238	90	28	.	.	.
cord-335198-qp964238	91	1	During	during	IN
cord-335198-qp964238	91	2	a	a	DT
cord-335198-qp964238	91	3	pandemic	pandemic	NN
cord-335198-qp964238	91	4	these	these	DT
cord-335198-qp964238	91	5	fundamentals	fundamental	NNS
cord-335198-qp964238	91	6	are	be	VBP
cord-335198-qp964238	91	7	unchanged	unchanged	JJ
cord-335198-qp964238	91	8	,	,	,
cord-335198-qp964238	91	9	although	although	IN
cord-335198-qp964238	91	10	our	-PRON-	PRP$
cord-335198-qp964238	91	11	responses	response	NNS
cord-335198-qp964238	91	12	now	now	RB
cord-335198-qp964238	91	13	have	have	VBP
cord-335198-qp964238	91	14	to	to	TO
cord-335198-qp964238	91	15	be	be	VB
cord-335198-qp964238	91	16	both	both	DT
cord-335198-qp964238	91	17	speedier	speedy	JJR
cord-335198-qp964238	91	18	and	and	CC
cord-335198-qp964238	91	19	as	as	RB
cord-335198-qp964238	91	20	complete	complete	JJ
cord-335198-qp964238	91	21	as	as	IN
cord-335198-qp964238	91	22	possible	possible	JJ
cord-335198-qp964238	91	23	with	with	IN
cord-335198-qp964238	91	24	a	a	DT
cord-335198-qp964238	91	25	varying	vary	VBG
cord-335198-qp964238	91	26	emphasis	emphasis	NN
cord-335198-qp964238	91	27	on	on	IN
cord-335198-qp964238	91	28	either	either	CC
cord-335198-qp964238	91	29	depending	depend	VBG
cord-335198-qp964238	91	30	on	on	IN
cord-335198-qp964238	91	31	the	the	DT
cord-335198-qp964238	91	32	guiding	guide	VBG
cord-335198-qp964238	91	33	framework	framework	NN
cord-335198-qp964238	91	34	and	and	CC
cord-335198-qp964238	91	35	associated	associate	VBN
cord-335198-qp964238	91	36	driving	drive	VBG
cord-335198-qp964238	91	37	purpose	purpose	NN
cord-335198-qp964238	91	38	.	.	.
cord-335198-qp964238	92	1	With	with	IN
cord-335198-qp964238	92	2	this	this	DT
cord-335198-qp964238	92	3	in	in	IN
cord-335198-qp964238	92	4	mind	mind	NN
cord-335198-qp964238	92	5	,	,	,
cord-335198-qp964238	92	6	doing	do	VBG
cord-335198-qp964238	92	7	the	the	DT
cord-335198-qp964238	92	8	most	most	RBS
cord-335198-qp964238	92	9	right	right	JJ
cord-335198-qp964238	92	10	thing	thing	NN
cord-335198-qp964238	92	11	,	,	,
cord-335198-qp964238	92	12	at	at	IN
cord-335198-qp964238	92	13	the	the	DT
cord-335198-qp964238	92	14	most	most	RBS
cord-335198-qp964238	92	15	right	right	JJ
cord-335198-qp964238	92	16	time	time	NN
cord-335198-qp964238	92	17	,	,	,
cord-335198-qp964238	92	18	in	in	IN
cord-335198-qp964238	92	19	the	the	DT
cord-335198-qp964238	92	20	most	most	RBS
cord-335198-qp964238	92	21	right	right	JJ
cord-335198-qp964238	92	22	way	way	NN
cord-335198-qp964238	92	23	for	for	IN
cord-335198-qp964238	92	24	the	the	DT
cord-335198-qp964238	92	25	one	one	CD
cord-335198-qp964238	92	26	and	and	CC
cord-335198-qp964238	92	27	the	the	DT
cord-335198-qp964238	92	28	many	many	JJ
cord-335198-qp964238	92	29	is	be	VBZ
cord-335198-qp964238	92	30	the	the	DT
cord-335198-qp964238	92	31	ethicist	ethicist	NN
cord-335198-qp964238	92	32	's	's	POS
cord-335198-qp964238	92	33	embrace	embrace	NN
cord-335198-qp964238	92	34	of	of	IN
cord-335198-qp964238	92	35	epistemological	epistemological	JJ
cord-335198-qp964238	92	36	excellence	excellence	NN
cord-335198-qp964238	92	37	and	and	CC
cord-335198-qp964238	92	38	the	the	DT
cord-335198-qp964238	92	39	flourishing	flourishing	NN
cord-335198-qp964238	92	40	of	of	IN
cord-335198-qp964238	92	41	all	all	DT
cord-335198-qp964238	92	42	.	.	.
cord-335198-qp964238	93	1	References	reference	NNS
cord-335198-qp964238	93	2	:	:	:
cord-335198-qp964238	93	3	Thoracic	Thoracic	NNP
cord-335198-qp964238	93	4	Society	Society	NNP
cord-335198-qp964238	93	5	of	of	IN
cord-335198-qp964238	93	6	Australia	Australia	NNP
cord-335198-qp964238	93	7	and	and	CC
cord-335198-qp964238	94	1	New	New	NNP
cord-335198-qp964238	94	2	Zealand	Zealand	NNP
cord-335198-qp964238	94	3	H1N1	H1N1	NNP
cord-335198-qp964238	94	4	Influenza	Influenza	NNP
cord-335198-qp964238	94	5	09	09	CD
cord-335198-qp964238	94	6	Task	Task	NNP
cord-335198-qp964238	94	7	Force	Force	NNP
cord-335198-qp964238	94	8	.	.	.
cord-335198-qp964238	95	1	Influenza	Influenza	NNP
cord-335198-qp964238	95	2	A	A	NNP
cord-335198-qp964238	95	3	/	/	SYM
cord-335198-qp964238	95	4	H1N1_09	h1n1_09	XX
cord-335198-qp964238	95	5	:	:	:
cord-335198-qp964238	96	1	Australia	Australia	NNP
cord-335198-qp964238	96	2	and	and	CC
cord-335198-qp964238	96	3	New	New	NNP
cord-335198-qp964238	96	4	Zealand	Zealand	NNP
cord-335198-qp964238	96	5	's	's	POS
cord-335198-qp964238	96	6	winter	winter	NN
cord-335198-qp964238	96	7	of	of	IN
cord-335198-qp964238	96	8	discontent	discontent	NN
cord-335198-qp964238	96	9	Clinical	clinical	JJ
cord-335198-qp964238	96	10	and	and	CC
cord-335198-qp964238	96	11	epidemiological	epidemiological	JJ
cord-335198-qp964238	96	12	profile	profile	NN
cord-335198-qp964238	96	13	of	of	IN
cord-335198-qp964238	96	14	patients	patient	NNS
cord-335198-qp964238	96	15	with	with	IN
cord-335198-qp964238	96	16	severe	severe	JJ
cord-335198-qp964238	96	17	H1N1/09	h1n1/09	JJ
cord-335198-qp964238	96	18	pandemic	pandemic	NN
cord-335198-qp964238	96	19	influenza	influenza	NN
cord-335198-qp964238	96	20	in	in	IN
cord-335198-qp964238	96	21	Australia	Australia	NNP
cord-335198-qp964238	96	22	and	and	CC
cord-335198-qp964238	96	23	New	New	NNP
cord-335198-qp964238	96	24	Zealand	Zealand	NNP
cord-335198-qp964238	96	25	:	:	:
cord-335198-qp964238	97	1	an	an	DT
cord-335198-qp964238	97	2	observational	observational	JJ
cord-335198-qp964238	97	3	cohort	cohort	NN
cord-335198-qp964238	97	4	study	study	NN
cord-335198-qp964238	97	5	Influenza	Influenza	NNP
cord-335198-qp964238	97	6	epidemiology	epidemiology	NN
cord-335198-qp964238	97	7	in	in	IN
cord-335198-qp964238	97	8	patients	patient	NNS
cord-335198-qp964238	97	9	admitted	admit	VBN
cord-335198-qp964238	97	10	to	to	IN
cord-335198-qp964238	97	11	sentinel	sentinel	JJ
cord-335198-qp964238	97	12	Australian	australian	JJ
cord-335198-qp964238	97	13	hospitals	hospital	NNS
cord-335198-qp964238	97	14	in	in	IN
cord-335198-qp964238	97	15	2018	2018	CD
cord-335198-qp964238	97	16	:	:	:
cord-335198-qp964238	97	17	the	the	DT
cord-335198-qp964238	97	18	Influenza	Influenza	NNP
cord-335198-qp964238	97	19	Complications	Complications	NNPS
cord-335198-qp964238	97	20	Alert	Alert	NNP
cord-335198-qp964238	97	21	Network	Network	NNP
cord-335198-qp964238	97	22	(	(	-LRB-
cord-335198-qp964238	97	23	FluCAN	FluCAN	NNP
cord-335198-qp964238	97	24	)	)	-RRB-
cord-335198-qp964238	98	1	The	the	DT
cord-335198-qp964238	98	2	role	role	NN
cord-335198-qp964238	98	3	of	of	IN
cord-335198-qp964238	98	4	chest	chest	NN
cord-335198-qp964238	98	5	imaging	imaging	NN
cord-335198-qp964238	98	6	in	in	IN
cord-335198-qp964238	98	7	patient	patient	JJ
cord-335198-qp964238	98	8	management	management	NN
cord-335198-qp964238	98	9	during	during	IN
cord-335198-qp964238	98	10	the	the	DT
cord-335198-qp964238	98	11	COVID-19	COVID-19	NNP
cord-335198-qp964238	98	12	pandemic	pandemic	NN
cord-335198-qp964238	98	13	:	:	:
cord-335198-qp964238	98	14	a	a	DT
cord-335198-qp964238	98	15	multinational	multinational	JJ
cord-335198-qp964238	98	16	consensus	consensus	NN
cord-335198-qp964238	98	17	statement	statement	NN
cord-335198-qp964238	98	18	from	from	IN
cord-335198-qp964238	98	19	the	the	DT
cord-335198-qp964238	98	20	Fleischner	Fleischner	NNP
cord-335198-qp964238	98	21	Society	Society	NNP
cord-335198-qp964238	98	22	Systematic	Systematic	NNP
cord-335198-qp964238	98	23	Review	Review	NNP
cord-335198-qp964238	98	24	of	of	IN
cord-335198-qp964238	98	25	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-335198-qp964238	98	26	Infectious	Infectious	NNP
cord-335198-qp964238	98	27	Disease	Disease	NNP
cord-335198-qp964238	98	28	Trials	trial	NNS
cord-335198-qp964238	98	29	Treating	treat	VBG
cord-335198-qp964238	98	30	Influenza	Influenza	NNP
cord-335198-qp964238	98	31	Infection	Infection	NNP
cord-335198-qp964238	98	32	,	,	,
cord-335198-qp964238	98	33	From	from	IN
cord-335198-qp964238	98	34	Now	now	RB
cord-335198-qp964238	98	35	and	and	CC
cord-335198-qp964238	98	36	Into	into	IN
cord-335198-qp964238	98	37	the	the	DT
cord-335198-qp964238	98	38	Future	future	NN
cord-335198-qp964238	98	39	.	.	.
cord-335198-qp964238	99	1	Front	Front	NNP
cord-335198-qp964238	99	2	Immunol	Immunol	NNP
cord-335198-qp964238	100	1	A	a	DT
cord-335198-qp964238	100	2	Trial	Trial	NNP
cord-335198-qp964238	100	3	of	of	IN
cord-335198-qp964238	100	4	Lopinavir	Lopinavir	NNP
cord-335198-qp964238	100	5	-	-	HYPH
cord-335198-qp964238	100	6	Ritonavir	Ritonavir	NNP
cord-335198-qp964238	100	7	in	in	IN
cord-335198-qp964238	100	8	Adults	Adults	NNPS
cord-335198-qp964238	100	9	Hospitalized	hospitalize	VBN
cord-335198-qp964238	100	10	with	with	IN
cord-335198-qp964238	100	11	Severe	severe	JJ
cord-335198-qp964238	100	12	Covid-19	Covid-19	NNP
cord-335198-qp964238	100	13	Observational	Observational	NNP
cord-335198-qp964238	100	14	Study	Study	NNP
cord-335198-qp964238	100	15	of	of	IN
cord-335198-qp964238	100	16	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-335198-qp964238	100	17	in	in	IN
cord-335198-qp964238	100	18	Hospitalized	Hospitalized	NNP
cord-335198-qp964238	100	19	Patients	Patients	NNP
cord-335198-qp964238	100	20	with	with	IN
cord-335198-qp964238	100	21	Covid-19	covid-19	NN
cord-335198-qp964238	100	22	:	:	:
cord-335198-qp964238	100	23	NEJM	NEJM	NNP
cord-335198-qp964238	100	24	.	.	.
cord-335198-qp964238	101	1	oa2012410	oa2012410	NNP
cord-335198-qp964238	101	2	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-335198-qp964238	101	3	or	or	CC
cord-335198-qp964238	101	4	chloroquine	chloroquine	NN
cord-335198-qp964238	101	5	with	with	IN
cord-335198-qp964238	101	6	or	or	CC
cord-335198-qp964238	101	7	without	without	IN
cord-335198-qp964238	101	8	a	a	DT
cord-335198-qp964238	101	9	macrolide	macrolide	NN
cord-335198-qp964238	101	10	for	for	IN
cord-335198-qp964238	101	11	treatment	treatment	NN
cord-335198-qp964238	101	12	of	of	IN
cord-335198-qp964238	101	13	COVID-19	COVID-19	NNP
cord-335198-qp964238	101	14	:	:	:
cord-335198-qp964238	101	15	a	a	DT
cord-335198-qp964238	101	16	multinational	multinational	JJ
cord-335198-qp964238	101	17	registry	registry	NN
cord-335198-qp964238	101	18	analysis	analysis	NN
cord-335198-qp964238	101	19	Compassionate	compassionate	JJ
cord-335198-qp964238	101	20	Use	Use	NNP
cord-335198-qp964238	101	21	of	of	IN
cord-335198-qp964238	101	22	Remdesivir	Remdesivir	NNP
cord-335198-qp964238	101	23	for	for	IN
cord-335198-qp964238	101	24	Patients	patient	NNS
cord-335198-qp964238	101	25	with	with	IN
cord-335198-qp964238	101	26	Severe	severe	JJ
cord-335198-qp964238	101	27	Covid-19	Covid-19	NNP
cord-335198-qp964238	101	28	ACTT-1	ACTT-1	NNP
cord-335198-qp964238	101	29	Study	Study	NNP
cord-335198-qp964238	101	30	Group	Group	NNP
cord-335198-qp964238	101	31	Members	Members	NNPS
cord-335198-qp964238	101	32	.	.	.
cord-335198-qp964238	102	1	Remdesivir	Remdesivir	NNP
cord-335198-qp964238	102	2	for	for	IN
cord-335198-qp964238	102	3	the	the	DT
cord-335198-qp964238	102	4	Treatment	Treatment	NNP
cord-335198-qp964238	102	5	of	of	IN
cord-335198-qp964238	102	6	Covid-19	Covid-19	NNP
cord-335198-qp964238	102	7	-Preliminary	-Preliminary	NNP
cord-335198-qp964238	102	8	Report	Report	NNP
cord-335198-qp964238	102	9	Asian	Asian	NNP
cord-335198-qp964238	102	10	Critical	Critical	NNP
cord-335198-qp964238	102	11	Care	Care	NNP
cord-335198-qp964238	102	12	Clinical	Clinical	NNP
cord-335198-qp964238	102	13	Trials	Trials	NNPS
cord-335198-qp964238	102	14	Group	Group	NNP
cord-335198-qp964238	102	15	.	.	.
cord-335198-qp964238	103	1	Intensive	intensive	JJ
cord-335198-qp964238	103	2	care	care	NN
cord-335198-qp964238	103	3	management	management	NN
cord-335198-qp964238	103	4	of	of	IN
cord-335198-qp964238	103	5	coronavirus	coronavirus	NN
cord-335198-qp964238	103	6	disease	disease	NNP
cord-335198-qp964238	103	7	2019	2019	CD
cord-335198-qp964238	103	8	(	(	-LRB-
cord-335198-qp964238	103	9	COVID-19	COVID-19	NNP
cord-335198-qp964238	103	10	)	)	-RRB-
cord-335198-qp964238	103	11	:	:	:
cord-335198-qp964238	103	12	challenges	challenge	NNS
cord-335198-qp964238	103	13	and	and	CC
cord-335198-qp964238	103	14	recommendations	recommendation	NNS
cord-335198-qp964238	103	15	Emerging	emerge	VBG
cord-335198-qp964238	103	16	pharmacotherapies	pharmacotherapie	NNS
cord-335198-qp964238	103	17	for	for	IN
cord-335198-qp964238	103	18	COVID-19	COVID-19	NNP
cord-335198-qp964238	103	19	Tsiodras	Tsiodras	NNP
cord-335198-qp964238	103	20	S	S	NNP
cord-335198-qp964238	103	21	;	;	:
cord-335198-qp964238	103	22	ESCMID	ESCMID	NNP
cord-335198-qp964238	103	23	Study	Study	NNP
cord-335198-qp964238	103	24	Group	Group	NNP
cord-335198-qp964238	103	25	for	for	IN
cord-335198-qp964238	103	26	Respiratory	respiratory	JJ
cord-335198-qp964238	103	27	Viruses	virus	NNS
cord-335198-qp964238	103	28	.	.	.
cord-335198-qp964238	104	1	Review	Review	NNP
cord-335198-qp964238	104	2	of	of	IN
cord-335198-qp964238	104	3	trials	trial	NNS
cord-335198-qp964238	104	4	currently	currently	RB
cord-335198-qp964238	104	5	testing	test	VBG
cord-335198-qp964238	104	6	treatment	treatment	NN
cord-335198-qp964238	104	7	and	and	CC
cord-335198-qp964238	104	8	prevention	prevention	NN
cord-335198-qp964238	104	9	of	of	IN
cord-335198-qp964238	104	10	COVID-19	COVID-19	NNP
cord-335198-qp964238	105	1	How	how	WRB
cord-335198-qp964238	105	2	did	do	VBD
cord-335198-qp964238	105	3	we	-PRON-	PRP
cord-335198-qp964238	105	4	rapidly	rapidly	RB
cord-335198-qp964238	105	5	implement	implement	VB
cord-335198-qp964238	105	6	a	a	DT
cord-335198-qp964238	105	7	convalescent	convalescent	JJ
cord-335198-qp964238	105	8	plasma	plasma	NN
cord-335198-qp964238	105	9	program	program	NN
cord-335198-qp964238	105	10	?	?	.
cord-335198-qp964238	106	1	Transfusion	transfusion	NN
cord-335198-qp964238	106	2	Trials	trial	NNS
cord-335198-qp964238	106	3	and	and	CC
cord-335198-qp964238	106	4	tribulations	tribulation	NNS
cord-335198-qp964238	106	5	:	:	:
cord-335198-qp964238	106	6	so	so	RB
cord-335198-qp964238	106	7	many	many	JJ
cord-335198-qp964238	106	8	potential	potential	JJ
cord-335198-qp964238	106	9	treatments	treatment	NNS
cord-335198-qp964238	106	10	,	,	,
cord-335198-qp964238	107	1	so	so	RB
cord-335198-qp964238	107	2	few	few	JJ
cord-335198-qp964238	107	3	answers	answer	NNS
cord-335198-qp964238	107	4	Off	off	IN
cord-335198-qp964238	107	5	-	-	HYPH
cord-335198-qp964238	107	6	label	label	NN
cord-335198-qp964238	107	7	use	use	NN
cord-335198-qp964238	107	8	of	of	IN
cord-335198-qp964238	107	9	tocilizumab	tocilizumab	NN
cord-335198-qp964238	107	10	for	for	IN
cord-335198-qp964238	107	11	the	the	DT
cord-335198-qp964238	107	12	treatment	treatment	NN
cord-335198-qp964238	107	13	of	of	IN
cord-335198-qp964238	107	14	SARS	SARS	NNP
cord-335198-qp964238	107	15	-	-	HYPH
cord-335198-qp964238	107	16	CoV-2	CoV-2	NNP
cord-335198-qp964238	107	17	pneumonia	pneumonia	NN
cord-335198-qp964238	107	18	in	in	IN
cord-335198-qp964238	107	19	Successful	successful	JJ
cord-335198-qp964238	107	20	recovery	recovery	NN
cord-335198-qp964238	107	21	from	from	IN
cord-335198-qp964238	107	22	severe	severe	JJ
cord-335198-qp964238	107	23	COVID-19	covid-19	JJ
cord-335198-qp964238	107	24	pneumonia	pneumonia	NN
cord-335198-qp964238	107	25	after	after	IN
cord-335198-qp964238	107	26	kidney	kidney	NN
cord-335198-qp964238	107	27	transplantation	transplantation	NN
cord-335198-qp964238	107	28	:	:	:
cord-335198-qp964238	108	1	the	the	DT
cord-335198-qp964238	108	2	interplay	interplay	NN
cord-335198-qp964238	108	3	between	between	IN
cord-335198-qp964238	108	4	immunosuppression	immunosuppression	NN
cord-335198-qp964238	108	5	and	and	CC
cord-335198-qp964238	108	6	novel	novel	NN
cord-335198-qp964238	108	7	therapy	therapy	NN
cord-335198-qp964238	108	8	including	include	VBG
cord-335198-qp964238	108	9	tocilizumab	tocilizumab	NNP
cord-335198-qp964238	108	10	Effective	effective	JJ
cord-335198-qp964238	108	11	treatment	treatment	NN
cord-335198-qp964238	108	12	of	of	IN
cord-335198-qp964238	108	13	severe	severe	JJ
cord-335198-qp964238	108	14	COVID-19	covid-19	JJ
cord-335198-qp964238	108	15	patients	patient	NNS
cord-335198-qp964238	108	16	with	with	IN
cord-335198-qp964238	108	17	tocilizumab	tocilizumab	NNP
cord-335198-qp964238	108	18	Triple	Triple	NNP
cord-335198-qp964238	108	19	combination	combination	NN
cord-335198-qp964238	108	20	of	of	IN
cord-335198-qp964238	108	21	interferon	interferon	NN
cord-335198-qp964238	108	22	beta-1b	beta-1b	NNP
cord-335198-qp964238	108	23	,	,	,
cord-335198-qp964238	108	24	lopinavir	lopinavir	NNS
cord-335198-qp964238	108	25	-	-	HYPH
cord-335198-qp964238	108	26	ritonavir	ritonavir	NNS
cord-335198-qp964238	108	27	,	,	,
cord-335198-qp964238	108	28	and	and	CC
cord-335198-qp964238	108	29	ribavirin	ribavirin	NN
cord-335198-qp964238	108	30	in	in	IN
cord-335198-qp964238	108	31	the	the	DT
cord-335198-qp964238	108	32	treatment	treatment	NN
cord-335198-qp964238	108	33	of	of	IN
cord-335198-qp964238	108	34	patients	patient	NNS
cord-335198-qp964238	108	35	admitted	admit	VBN
cord-335198-qp964238	108	36	to	to	IN
cord-335198-qp964238	108	37	hospital	hospital	NN
cord-335198-qp964238	108	38	with	with	IN
cord-335198-qp964238	108	39	COVID-19	COVID-19	NNP
cord-335198-qp964238	108	40	:	:	:
cord-335198-qp964238	108	41	an	an	DT
cord-335198-qp964238	108	42	open	open	JJ
cord-335198-qp964238	108	43	-	-	HYPH
cord-335198-qp964238	108	44	label	label	NN
cord-335198-qp964238	108	45	,	,	,
cord-335198-qp964238	108	46	randomised	randomised	JJ
cord-335198-qp964238	108	47	,	,	,
cord-335198-qp964238	108	48	phase	phase	NN
cord-335198-qp964238	108	49	2	2	CD
cord-335198-qp964238	108	50	trial	trial	NN
cord-335198-qp964238	108	51	Solidarity	Solidarity	NNP
cord-335198-qp964238	108	52	"	"	''
cord-335198-qp964238	108	53	clinical	clinical	JJ
cord-335198-qp964238	108	54	trial	trial	NN
cord-335198-qp964238	108	55	for	for	IN
cord-335198-qp964238	108	56	COVID-19	covid-19	JJ
cord-335198-qp964238	108	57	treatments	treatment	NNS
cord-335198-qp964238	108	58	:	:	:
cord-335198-qp964238	108	59	6	6	CD
cord-335198-qp964238	108	60	th	th	XX
cord-335198-qp964238	109	1	Why	why	WRB
cord-335198-qp964238	109	2	have	have	VBP
cord-335198-qp964238	109	3	n't	not	RB
cord-335198-qp964238	109	4	others	other	NNS
cord-335198-qp964238	109	5	delivered	deliver	VBN
cord-335198-qp964238	109	6	more	more	JJR
cord-335198-qp964238	109	7	results	result	NNS
cord-335198-qp964238	109	8	?	?	.
cord-335198-qp964238	110	1	Kai	Kai	NNP
cord-335198-qp964238	110	2	Kupferschmidt	Kupferschmidt	NNP
cord-335198-qp964238	110	3	Effect	Effect	NNP
cord-335198-qp964238	110	4	of	of	IN
cord-335198-qp964238	110	5	Dexamethasone	Dexamethasone	NNP
cord-335198-qp964238	110	6	in	in	IN
cord-335198-qp964238	110	7	Hospitalized	Hospitalized	NNP
cord-335198-qp964238	110	8	Patients	Patients	NNP
cord-335198-qp964238	110	9	with	with	IN
cord-335198-qp964238	110	10	COVID-19	COVID-19	NNP
cord-335198-qp964238	111	1	-Preliminary	-preliminary	RB
cord-335198-qp964238	111	2	Report	Report	NNP
cord-335198-qp964238	111	3	MedRxiv	MedRxiv	NNP
cord-335198-qp964238	111	4	22	22	CD
cord-335198-qp964238	111	5	nd	nd	NNP