id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-013601-y8pc4qfc	Zhou, Bo-ya	Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization	2020-04-23		.txt	text/plain	6143	299	45	This study aimed to explore the targeted drug effect of nintedanib on antagonizing multiple signaling pathways related to VEGF-R, FGF-R, PDGF-R, and TGF-β-R and examine its therapeutic effect on keloid fibroblast behaviors, including cell proliferation, cell cycle progression, overproduction of extracellular matrix, cell migration, and cell invasion, using in vitro and ex vivo models. However, treatment with increasing concentrations of nintedanib for 7 days significantly inhibited KFs from migrating out of the tissue explants in a dose-dependent manner with significant differences from that of the control group (P < 0.05). As presented in Fig. 4a , at the transcriptional level, treatment with the drug at concentrations of 1, 2, and 4 μM for 72 h significantly suppressed the gene expression of COL-1, FN, connective tissue growth factor (CTGF), plasminogen activator inhibitor-1 (PAI-1), and FK506-binding protein 10 (FKBP10) in a dose-dependent manner, with significant differences among the groups (P < 0.05).	./cache/cord-013601-y8pc4qfc.txt	./txt/cord-013601-y8pc4qfc.txt