id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002282-ldfa616a	Joung, Young Hee	The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B	2016-10-13		.txt	text/plain	8136	449	42	Another important advantage as emerging vaccine is the more effective activation of key aspects of the immune response to achieve potent immune stimulation and to provide immunological memory for long-lasting protection [22, 23] Plant-based platforms including whole plant, organs or cell and expression technology to produce target antigens of interest are diverse [38] [39] [40] . In the case of plant-derived HBV vaccines, the first report was on the expression of the small hepatitis B surface antigen (S-HBsAg) in transgenic tobacco plants. In the transgenic tobacco plant transformed with the S-HBsAg gene controlled by the 35S promoter, expression levels were very low: less than 0.01% total soluble protein and less than 10 ng/g fresh weight in leaf tissues. Expression of the human hepatitis B virus large surface antigen gene in transgenic tomato plants Oral immunization of human with transgenic lettuce expressing hepatitis B surface antigen	./cache/cord-002282-ldfa616a.txt	./txt/cord-002282-ldfa616a.txt