id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340900-f2iuy9e1	Wehling, Martin	Calling for an exponential escalation scheme in vaccine development for COVID-19	2020-06-16		.txt	text/plain	1032	55	51	CONCLUSION: A COVID-19 vaccine would be rapidly available at a slightly increased risk for undetected late side effects or insufficient efficacy if compared with standard vaccine development schemes. Absence of structural homologies of antibody targets with protein structures normally present in humans, analogous to the still disputed induction of narcolepsia by the influenza vaccine Pandemrix due to a structural homology with the hypocretin receptor [3] I suggest exponential exposure starting with 10 healthy volunteers, testing of antibody responses and safety after 14 days; if no stoppers [lack of adequate (see points 1-3 above) antibody response, intolerable side effects] occur, the number of vaccinated people will be increased by tenfold in each subsequent step, in this case to the next cohort of 100 people. At stage 3 + (1000 + people) when primary efficacy has been established at the antibody level and safety is no issue to this point, volunteers living in countries with high infection rates should be vaccinated.	./cache/cord-340900-f2iuy9e1.txt	./txt/cord-340900-f2iuy9e1.txt