id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342831-4qfe8kok	Xia, Yufei	Chitosan-based mucosal adjuvants: Sunrise on the ocean	2015-11-04		.txt	text/plain	7863	380	39	Chitosan-based formulations have been found to orchestrate both cellular and humoral responses, and represent the most promising candidates for adjuvant and delivery systems for mucosal vaccines [37] . Recently, chitosan-based adjuvant systems have been proven to have mucoadhesive qualities and the unique ability to open the tight junctions between epithelial cells at natural portals, which stimulates a robust mucosal immune response by facilitating the transport of antigens via an alternative yet effective route for antigen delivery [5, 30, 39, 74, 75] . In pre-clinical and clinical research, chitosan and its derivatives have demonstrated low-toxicity, mucoadhesive capabilities, the ability to enhance the internalization of antigens by APCs, and immune-stimulatory properties, which makes them promising candidates for effective mucosal adjuvants [5] . Development and characterization of surface modified PLGA nanoparticles for nasal vaccine delivery: effect of mucoadhesive coating on antigen uptake and immune adjuvant activity	./cache/cord-342831-4qfe8kok.txt	./txt/cord-342831-4qfe8kok.txt