id sid tid token lemma pos cord-269992-ruf0vvz4 1 1 key key JJ cord-269992-ruf0vvz4 2 1 : : : cord-269992-ruf0vvz4 2 2 cord-269992-ruf0vvz4 cord-269992-ruf0vvz4 NN cord-269992-ruf0vvz4 2 3 authors author NNS cord-269992-ruf0vvz4 2 4 : : : cord-269992-ruf0vvz4 3 1 Sohrab Sohrab NNP cord-269992-ruf0vvz4 3 2 , , , cord-269992-ruf0vvz4 3 3 Sayed Sayed NNP cord-269992-ruf0vvz4 3 4 Sartaj Sartaj NNP cord-269992-ruf0vvz4 3 5 title title NN cord-269992-ruf0vvz4 3 6 : : : cord-269992-ruf0vvz4 4 1 An an DT cord-269992-ruf0vvz4 4 2 edible edible JJ cord-269992-ruf0vvz4 4 3 vaccine vaccine NN cord-269992-ruf0vvz4 4 4 development development NN cord-269992-ruf0vvz4 4 5 for for IN cord-269992-ruf0vvz4 4 6 coronavirus coronavirus NN cord-269992-ruf0vvz4 4 7 disease disease NN cord-269992-ruf0vvz4 4 8 2019 2019 CD cord-269992-ruf0vvz4 4 9 : : : cord-269992-ruf0vvz4 4 10 the the DT cord-269992-ruf0vvz4 4 11 concept concept NN cord-269992-ruf0vvz4 4 12 date date NN cord-269992-ruf0vvz4 4 13 : : : cord-269992-ruf0vvz4 4 14 2020 2020 CD cord-269992-ruf0vvz4 4 15 - - HYPH cord-269992-ruf0vvz4 4 16 07 07 CD cord-269992-ruf0vvz4 4 17 - - HYPH cord-269992-ruf0vvz4 4 18 31 31 CD cord-269992-ruf0vvz4 4 19 journal journal NN cord-269992-ruf0vvz4 4 20 : : : cord-269992-ruf0vvz4 5 1 Clin Clin NNP cord-269992-ruf0vvz4 5 2 Exp Exp NNP cord-269992-ruf0vvz4 5 3 Vaccine Vaccine NNP cord-269992-ruf0vvz4 5 4 Res Res NNP cord-269992-ruf0vvz4 5 5 DOI doi NN cord-269992-ruf0vvz4 6 1 : : : cord-269992-ruf0vvz4 6 2 10.7774 10.7774 LS cord-269992-ruf0vvz4 6 3 / / SYM cord-269992-ruf0vvz4 6 4 cevr.2020.9.2.164 cevr.2020.9.2.164 NN cord-269992-ruf0vvz4 6 5 sha sha NN cord-269992-ruf0vvz4 6 6 : : : cord-269992-ruf0vvz4 7 1 b28e9a9ca13672580aef48bb16b48fd8518823c5 b28e9a9ca13672580aef48bb16b48fd8518823c5 NNP cord-269992-ruf0vvz4 7 2 doc_id doc_id CD cord-269992-ruf0vvz4 7 3 : : : cord-269992-ruf0vvz4 8 1 269992 269992 CD cord-269992-ruf0vvz4 8 2 cord_uid cord_uid NNS cord-269992-ruf0vvz4 8 3 : : : cord-269992-ruf0vvz4 8 4 ruf0vvz4 ruf0vvz4 VB cord-269992-ruf0vvz4 9 1 A a DT cord-269992-ruf0vvz4 9 2 novel novel JJ cord-269992-ruf0vvz4 9 3 coronavirus coronavirus NN cord-269992-ruf0vvz4 9 4 was be VBD cord-269992-ruf0vvz4 9 5 emerged emerge VBN cord-269992-ruf0vvz4 9 6 in in IN cord-269992-ruf0vvz4 9 7 December December NNP cord-269992-ruf0vvz4 9 8 2019 2019 CD cord-269992-ruf0vvz4 9 9 from from IN cord-269992-ruf0vvz4 9 10 Wuhan Wuhan NNP cord-269992-ruf0vvz4 9 11 city city NN cord-269992-ruf0vvz4 9 12 , , , cord-269992-ruf0vvz4 9 13 China China NNP cord-269992-ruf0vvz4 9 14 and and CC cord-269992-ruf0vvz4 9 15 has have VBZ cord-269992-ruf0vvz4 9 16 now now RB cord-269992-ruf0vvz4 9 17 become become VBN cord-269992-ruf0vvz4 9 18 a a DT cord-269992-ruf0vvz4 9 19 global global JJ cord-269992-ruf0vvz4 9 20 threat threat NN cord-269992-ruf0vvz4 9 21 to to IN cord-269992-ruf0vvz4 9 22 human human JJ cord-269992-ruf0vvz4 9 23 health health NN cord-269992-ruf0vvz4 9 24 . . . cord-269992-ruf0vvz4 10 1 Currently currently RB cord-269992-ruf0vvz4 10 2 , , , cord-269992-ruf0vvz4 10 3 the the DT cord-269992-ruf0vvz4 10 4 coronavirus coronavirus NN cord-269992-ruf0vvz4 10 5 disease disease NN cord-269992-ruf0vvz4 10 6 2019 2019 CD cord-269992-ruf0vvz4 10 7 ( ( -LRB- cord-269992-ruf0vvz4 10 8 COVID-19 COVID-19 NNP cord-269992-ruf0vvz4 10 9 ) ) -RRB- cord-269992-ruf0vvz4 10 10 has have VBZ cord-269992-ruf0vvz4 10 11 spread spread VBN cord-269992-ruf0vvz4 10 12 to to IN cord-269992-ruf0vvz4 10 13 more more JJR cord-269992-ruf0vvz4 10 14 than than IN cord-269992-ruf0vvz4 10 15 34 34 CD cord-269992-ruf0vvz4 10 16 countries country NNS cord-269992-ruf0vvz4 10 17 with with IN cord-269992-ruf0vvz4 10 18 2,445 2,445 CD cord-269992-ruf0vvz4 10 19 deaths death NNS cord-269992-ruf0vvz4 10 20 and and CC cord-269992-ruf0vvz4 10 21 78,811 78,811 CD cord-269992-ruf0vvz4 10 22 confirmed confirm VBN cord-269992-ruf0vvz4 10 23 cases case NNS cord-269992-ruf0vvz4 10 24 . . . cord-269992-ruf0vvz4 11 1 Currently currently RB cord-269992-ruf0vvz4 11 2 , , , cord-269992-ruf0vvz4 11 3 there there EX cord-269992-ruf0vvz4 11 4 is be VBZ cord-269992-ruf0vvz4 11 5 no no DT cord-269992-ruf0vvz4 11 6 vaccine vaccine NN cord-269992-ruf0vvz4 11 7 available available JJ cord-269992-ruf0vvz4 11 8 against against IN cord-269992-ruf0vvz4 11 9 COVID-19 COVID-19 NNP cord-269992-ruf0vvz4 11 10 . . . cord-269992-ruf0vvz4 12 1 The the DT cord-269992-ruf0vvz4 12 2 traditional traditional JJ cord-269992-ruf0vvz4 12 3 vaccines vaccine NNS cord-269992-ruf0vvz4 12 4 development development NN cord-269992-ruf0vvz4 12 5 requires require VBZ cord-269992-ruf0vvz4 12 6 more more JJR cord-269992-ruf0vvz4 12 7 time time NN cord-269992-ruf0vvz4 12 8 and and CC cord-269992-ruf0vvz4 12 9 high high JJ cord-269992-ruf0vvz4 12 10 cost cost NN cord-269992-ruf0vvz4 12 11 and and CC cord-269992-ruf0vvz4 12 12 due due IN cord-269992-ruf0vvz4 12 13 to to IN cord-269992-ruf0vvz4 12 14 this this DT cord-269992-ruf0vvz4 12 15 , , , cord-269992-ruf0vvz4 12 16 the the DT cord-269992-ruf0vvz4 12 17 disease disease NN cord-269992-ruf0vvz4 12 18 outbreaks outbreak NNS cord-269992-ruf0vvz4 12 19 becomes become VBZ cord-269992-ruf0vvz4 12 20 more more RBR cord-269992-ruf0vvz4 12 21 challenging challenging JJ cord-269992-ruf0vvz4 12 22 . . . cord-269992-ruf0vvz4 13 1 Now now RB cord-269992-ruf0vvz4 13 2 a a DT cord-269992-ruf0vvz4 13 3 days day NNS cord-269992-ruf0vvz4 13 4 , , , cord-269992-ruf0vvz4 13 5 plants plant NNS cord-269992-ruf0vvz4 13 6 have have VBP cord-269992-ruf0vvz4 13 7 become become VBN cord-269992-ruf0vvz4 13 8 more more RBR cord-269992-ruf0vvz4 13 9 attractive attractive JJ cord-269992-ruf0vvz4 13 10 platform platform NN cord-269992-ruf0vvz4 13 11 for for IN cord-269992-ruf0vvz4 13 12 edible edible JJ cord-269992-ruf0vvz4 13 13 vaccine vaccine NN cord-269992-ruf0vvz4 13 14 production production NN cord-269992-ruf0vvz4 13 15 than than IN cord-269992-ruf0vvz4 13 16 the the DT cord-269992-ruf0vvz4 13 17 other other JJ cord-269992-ruf0vvz4 13 18 system system NN cord-269992-ruf0vvz4 13 19 . . . cord-269992-ruf0vvz4 14 1 The the DT cord-269992-ruf0vvz4 14 2 development development NN cord-269992-ruf0vvz4 14 3 of of IN cord-269992-ruf0vvz4 14 4 an an DT cord-269992-ruf0vvz4 14 5 edible edible JJ cord-269992-ruf0vvz4 14 6 vaccine vaccine NN cord-269992-ruf0vvz4 14 7 in in IN cord-269992-ruf0vvz4 14 8 a a DT cord-269992-ruf0vvz4 14 9 selected select VBN cord-269992-ruf0vvz4 14 10 plant plant NN cord-269992-ruf0vvz4 14 11 system system NN cord-269992-ruf0vvz4 14 12 has have VBZ cord-269992-ruf0vvz4 14 13 many many JJ cord-269992-ruf0vvz4 14 14 significant significant JJ cord-269992-ruf0vvz4 14 15 advantages advantage NNS cord-269992-ruf0vvz4 14 16 such such JJ cord-269992-ruf0vvz4 14 17 as as IN cord-269992-ruf0vvz4 14 18 ; ; : cord-269992-ruf0vvz4 14 19 easy easy JJ cord-269992-ruf0vvz4 14 20 and and CC cord-269992-ruf0vvz4 14 21 efficient efficient JJ cord-269992-ruf0vvz4 14 22 oral oral JJ cord-269992-ruf0vvz4 14 23 delivery delivery NN cord-269992-ruf0vvz4 14 24 , , , cord-269992-ruf0vvz4 14 25 low low JJ cord-269992-ruf0vvz4 14 26 cost cost NN cord-269992-ruf0vvz4 14 27 with with IN cord-269992-ruf0vvz4 14 28 higher high JJR cord-269992-ruf0vvz4 14 29 scale scale NN cord-269992-ruf0vvz4 14 30 production production NN cord-269992-ruf0vvz4 14 31 , , , cord-269992-ruf0vvz4 14 32 avoidance avoidance NN cord-269992-ruf0vvz4 14 33 of of IN cord-269992-ruf0vvz4 14 34 any any DT cord-269992-ruf0vvz4 14 35 trained train VBN cord-269992-ruf0vvz4 14 36 medical medical JJ cord-269992-ruf0vvz4 14 37 personnel personnel NNS cord-269992-ruf0vvz4 14 38 for for IN cord-269992-ruf0vvz4 14 39 delivery delivery NN cord-269992-ruf0vvz4 14 40 , , , cord-269992-ruf0vvz4 14 41 lack lack NN cord-269992-ruf0vvz4 14 42 of of IN cord-269992-ruf0vvz4 14 43 any any DT cord-269992-ruf0vvz4 14 44 pathogenic pathogenic JJ cord-269992-ruf0vvz4 14 45 infection infection NN cord-269992-ruf0vvz4 14 46 , , , cord-269992-ruf0vvz4 14 47 multicomponent multicomponent JJ cord-269992-ruf0vvz4 14 48 expression expression NN cord-269992-ruf0vvz4 14 49 in in IN cord-269992-ruf0vvz4 14 50 a a DT cord-269992-ruf0vvz4 14 51 single single JJ cord-269992-ruf0vvz4 14 52 plant plant NN cord-269992-ruf0vvz4 14 53 , , , cord-269992-ruf0vvz4 14 54 and and CC cord-269992-ruf0vvz4 14 55 so so RB cord-269992-ruf0vvz4 14 56 forth forth RB cord-269992-ruf0vvz4 14 57 . . . cord-269992-ruf0vvz4 15 1 In in IN cord-269992-ruf0vvz4 15 2 this this DT cord-269992-ruf0vvz4 15 3 manuscript manuscript NN cord-269992-ruf0vvz4 15 4 , , , cord-269992-ruf0vvz4 15 5 the the DT cord-269992-ruf0vvz4 15 6 concept concept NN cord-269992-ruf0vvz4 15 7 , , , cord-269992-ruf0vvz4 15 8 development development NN cord-269992-ruf0vvz4 15 9 , , , cord-269992-ruf0vvz4 15 10 and and CC cord-269992-ruf0vvz4 15 11 importance importance NN cord-269992-ruf0vvz4 15 12 of of IN cord-269992-ruf0vvz4 15 13 an an DT cord-269992-ruf0vvz4 15 14 edible edible JJ cord-269992-ruf0vvz4 15 15 vaccine vaccine NN cord-269992-ruf0vvz4 15 16 have have VBP cord-269992-ruf0vvz4 15 17 been be VBN cord-269992-ruf0vvz4 15 18 discussed discuss VBN cord-269992-ruf0vvz4 15 19 . . . cord-269992-ruf0vvz4 16 1 By by IN cord-269992-ruf0vvz4 16 2 using use VBG cord-269992-ruf0vvz4 16 3 this this DT cord-269992-ruf0vvz4 16 4 plant plant NN cord-269992-ruf0vvz4 16 5 - - HYPH cord-269992-ruf0vvz4 16 6 based base VBN cord-269992-ruf0vvz4 16 7 platform platform NN cord-269992-ruf0vvz4 16 8 , , , cord-269992-ruf0vvz4 16 9 an an DT cord-269992-ruf0vvz4 16 10 edible edible JJ cord-269992-ruf0vvz4 16 11 vaccines vaccine NNS cord-269992-ruf0vvz4 16 12 can can MD cord-269992-ruf0vvz4 16 13 be be VB cord-269992-ruf0vvz4 16 14 produced produce VBN cord-269992-ruf0vvz4 16 15 in in IN cord-269992-ruf0vvz4 16 16 many many JJ cord-269992-ruf0vvz4 16 17 crops crop NNS cord-269992-ruf0vvz4 16 18 like like IN cord-269992-ruf0vvz4 16 19 banana banana NN cord-269992-ruf0vvz4 16 20 , , , cord-269992-ruf0vvz4 16 21 cucumber cucumber NN cord-269992-ruf0vvz4 16 22 , , , cord-269992-ruf0vvz4 16 23 carrot carrot NN cord-269992-ruf0vvz4 16 24 , , , cord-269992-ruf0vvz4 16 25 lettuce lettuce NN cord-269992-ruf0vvz4 16 26 , , , cord-269992-ruf0vvz4 16 27 and and CC cord-269992-ruf0vvz4 16 28 tomato tomato NN cord-269992-ruf0vvz4 16 29 against against IN cord-269992-ruf0vvz4 16 30 various various JJ cord-269992-ruf0vvz4 16 31 diseases disease NNS cord-269992-ruf0vvz4 16 32 . . . cord-269992-ruf0vvz4 17 1 Due due IN cord-269992-ruf0vvz4 17 2 to to IN cord-269992-ruf0vvz4 17 3 increasing increase VBG cord-269992-ruf0vvz4 17 4 cases case NNS cord-269992-ruf0vvz4 17 5 globally globally RB cord-269992-ruf0vvz4 17 6 with with IN cord-269992-ruf0vvz4 17 7 COVID-19 COVID-19 NNP cord-269992-ruf0vvz4 17 8 , , , cord-269992-ruf0vvz4 17 9 there there EX cord-269992-ruf0vvz4 17 10 is be VBZ cord-269992-ruf0vvz4 17 11 an an DT cord-269992-ruf0vvz4 17 12 urgent urgent JJ cord-269992-ruf0vvz4 17 13 requirement requirement NN cord-269992-ruf0vvz4 17 14 to to TO cord-269992-ruf0vvz4 17 15 develop develop VB cord-269992-ruf0vvz4 17 16 an an DT cord-269992-ruf0vvz4 17 17 ideal ideal JJ cord-269992-ruf0vvz4 17 18 vaccine vaccine NN cord-269992-ruf0vvz4 17 19 and and CC cord-269992-ruf0vvz4 17 20 antiviral antiviral JJ cord-269992-ruf0vvz4 17 21 therapy therapy NN cord-269992-ruf0vvz4 17 22 against against IN cord-269992-ruf0vvz4 17 23 this this DT cord-269992-ruf0vvz4 17 24 virus virus NN cord-269992-ruf0vvz4 17 25 to to TO cord-269992-ruf0vvz4 17 26 control control VB cord-269992-ruf0vvz4 17 27 the the DT cord-269992-ruf0vvz4 17 28 disease disease NN cord-269992-ruf0vvz4 17 29 worldwide worldwide RB cord-269992-ruf0vvz4 17 30 . . . cord-269992-ruf0vvz4 18 1 China China NNP cord-269992-ruf0vvz4 18 2 with with IN cord-269992-ruf0vvz4 18 3 2,445 2,445 CD cord-269992-ruf0vvz4 18 4 deaths death NNS cord-269992-ruf0vvz4 18 5 and and CC cord-269992-ruf0vvz4 18 6 78,811 78,811 CD cord-269992-ruf0vvz4 18 7 laboratory laboratory NN cord-269992-ruf0vvz4 18 8 confirmed confirm VBD cord-269992-ruf0vvz4 18 9 cases case NNS cord-269992-ruf0vvz4 18 10 [ [ -LRB- cord-269992-ruf0vvz4 18 11 1 1 CD cord-269992-ruf0vvz4 18 12 , , , cord-269992-ruf0vvz4 18 13 2 2 CD cord-269992-ruf0vvz4 18 14 ] ] -RRB- cord-269992-ruf0vvz4 18 15 . . . cord-269992-ruf0vvz4 19 1 Based base VBN cord-269992-ruf0vvz4 19 2 on on IN cord-269992-ruf0vvz4 19 3 medical medical JJ cord-269992-ruf0vvz4 19 4 and and CC cord-269992-ruf0vvz4 19 5 healthcare healthcare NN cord-269992-ruf0vvz4 19 6 workers worker NNS cord-269992-ruf0vvz4 19 7 , , , cord-269992-ruf0vvz4 19 8 the the DT cord-269992-ruf0vvz4 19 9 medical medical JJ cord-269992-ruf0vvz4 19 10 supplies supply NNS cord-269992-ruf0vvz4 19 11 are be VBP cord-269992-ruf0vvz4 19 12 getting get VBG cord-269992-ruf0vvz4 19 13 low low JJ cord-269992-ruf0vvz4 19 14 due due IN cord-269992-ruf0vvz4 19 15 to to IN cord-269992-ruf0vvz4 19 16 the the DT cord-269992-ruf0vvz4 19 17 high high JJ cord-269992-ruf0vvz4 19 18 number number NN cord-269992-ruf0vvz4 19 19 of of IN cord-269992-ruf0vvz4 19 20 cases case NNS cord-269992-ruf0vvz4 19 21 in in IN cord-269992-ruf0vvz4 19 22 Wuhan Wuhan NNP cord-269992-ruf0vvz4 19 23 city city NN cord-269992-ruf0vvz4 19 24 . . . cord-269992-ruf0vvz4 20 1 To to TO cord-269992-ruf0vvz4 20 2 manage manage VB cord-269992-ruf0vvz4 20 3 the the DT cord-269992-ruf0vvz4 20 4 cases case NNS cord-269992-ruf0vvz4 20 5 , , , cord-269992-ruf0vvz4 20 6 China China NNP cord-269992-ruf0vvz4 20 7 has have VBZ cord-269992-ruf0vvz4 20 8 announced announce VBN cord-269992-ruf0vvz4 20 9 to to TO cord-269992-ruf0vvz4 20 10 build build VB cord-269992-ruf0vvz4 20 11 two two CD cord-269992-ruf0vvz4 20 12 new new JJ cord-269992-ruf0vvz4 20 13 hospitals hospital NNS cord-269992-ruf0vvz4 20 14 with with IN cord-269992-ruf0vvz4 20 15 1,000 1,000 CD cord-269992-ruf0vvz4 20 16 beds bed NNS cord-269992-ruf0vvz4 20 17 within within IN cord-269992-ruf0vvz4 20 18 6 6 CD cord-269992-ruf0vvz4 20 19 days day NNS cord-269992-ruf0vvz4 20 20 which which WDT cord-269992-ruf0vvz4 20 21 is be VBZ cord-269992-ruf0vvz4 20 22 functional functional JJ cord-269992-ruf0vvz4 20 23 now now RB cord-269992-ruf0vvz4 20 24 . . . cord-269992-ruf0vvz4 21 1 The the DT cord-269992-ruf0vvz4 21 2 outbreak outbreak NN cord-269992-ruf0vvz4 21 3 caused cause VBN cord-269992-ruf0vvz4 21 4 by by IN cord-269992-ruf0vvz4 21 5 COVID-19 COVID-19 NNP cord-269992-ruf0vvz4 21 6 in in IN cord-269992-ruf0vvz4 21 7 Wuhan Wuhan NNP cord-269992-ruf0vvz4 21 8 is be VBZ cord-269992-ruf0vvz4 21 9 an an DT cord-269992-ruf0vvz4 21 10 epidemic epidemic JJ cord-269992-ruf0vvz4 21 11 threat threat NN cord-269992-ruf0vvz4 21 12 to to IN cord-269992-ruf0vvz4 21 13 global global JJ cord-269992-ruf0vvz4 21 14 health health NN cord-269992-ruf0vvz4 21 15 [ [ -LRB- cord-269992-ruf0vvz4 21 16 1 1 CD cord-269992-ruf0vvz4 21 17 , , , cord-269992-ruf0vvz4 21 18 2 2 CD cord-269992-ruf0vvz4 21 19 ] ] -RRB- cord-269992-ruf0vvz4 21 20 . . . cord-269992-ruf0vvz4 22 1 Currently currently RB cord-269992-ruf0vvz4 22 2 , , , cord-269992-ruf0vvz4 22 3 there there EX cord-269992-ruf0vvz4 22 4 are be VBP cord-269992-ruf0vvz4 22 5 many many JJ cord-269992-ruf0vvz4 22 6 systems system NNS cord-269992-ruf0vvz4 22 7 available available JJ cord-269992-ruf0vvz4 22 8 such such JJ cord-269992-ruf0vvz4 22 9 as as IN cord-269992-ruf0vvz4 22 10 bacteria bacteria NNS cord-269992-ruf0vvz4 22 11 , , , cord-269992-ruf0vvz4 22 12 yeast yeast NN cord-269992-ruf0vvz4 22 13 , , , cord-269992-ruf0vvz4 22 14 and and CC cord-269992-ruf0vvz4 22 15 mammalian mammalian JJ cord-269992-ruf0vvz4 22 16 cell cell NN cord-269992-ruf0vvz4 22 17 lines line NNS cord-269992-ruf0vvz4 22 18 to to TO cord-269992-ruf0vvz4 22 19 express express VB cord-269992-ruf0vvz4 22 20 the the DT cord-269992-ruf0vvz4 22 21 recombinant recombinant JJ cord-269992-ruf0vvz4 22 22 subunit subunit NN cord-269992-ruf0vvz4 22 23 vaccines vaccine NNS cord-269992-ruf0vvz4 22 24 and and CC cord-269992-ruf0vvz4 22 25 therapeutic therapeutic JJ cord-269992-ruf0vvz4 22 26 proteins protein NNS cord-269992-ruf0vvz4 22 27 but but CC cord-269992-ruf0vvz4 23 1 all all PDT cord-269992-ruf0vvz4 23 2 the the DT cord-269992-ruf0vvz4 23 3 above above JJ cord-269992-ruf0vvz4 23 4 systems system NNS cord-269992-ruf0vvz4 23 5 have have VBP cord-269992-ruf0vvz4 23 6 some some DT cord-269992-ruf0vvz4 23 7 disadvantages disadvantage NNS cord-269992-ruf0vvz4 23 8 like like IN cord-269992-ruf0vvz4 23 9 high high JJ cord-269992-ruf0vvz4 23 10 cost cost NN cord-269992-ruf0vvz4 23 11 , , , cord-269992-ruf0vvz4 23 12 safety safety NN cord-269992-ruf0vvz4 23 13 , , , cord-269992-ruf0vvz4 23 14 and and CC cord-269992-ruf0vvz4 23 15 target target VB cord-269992-ruf0vvz4 23 16 integrity integrity NN cord-269992-ruf0vvz4 23 17 . . . cord-269992-ruf0vvz4 24 1 While while IN cord-269992-ruf0vvz4 24 2 , , , cord-269992-ruf0vvz4 24 3 by by IN cord-269992-ruf0vvz4 24 4 using use VBG cord-269992-ruf0vvz4 24 5 plant plant NN cord-269992-ruf0vvz4 24 6 - - HYPH cord-269992-ruf0vvz4 24 7 based base VBN cord-269992-ruf0vvz4 24 8 system system NN cord-269992-ruf0vvz4 24 9 is be VBZ cord-269992-ruf0vvz4 24 10 very very RB cord-269992-ruf0vvz4 24 11 useful useful JJ cord-269992-ruf0vvz4 24 12 and and CC cord-269992-ruf0vvz4 24 13 avoids avoid VBZ cord-269992-ruf0vvz4 24 14 all all PDT cord-269992-ruf0vvz4 24 15 the the DT cord-269992-ruf0vvz4 24 16 issue issue NN cord-269992-ruf0vvz4 24 17 as as IN cord-269992-ruf0vvz4 24 18 compared compare VBN cord-269992-ruf0vvz4 24 19 to to IN cord-269992-ruf0vvz4 24 20 other other JJ cord-269992-ruf0vvz4 24 21 system system NN cord-269992-ruf0vvz4 24 22 and and CC cord-269992-ruf0vvz4 24 23 provides provide VBZ cord-269992-ruf0vvz4 24 24 low low JJ cord-269992-ruf0vvz4 24 25 cost cost NN cord-269992-ruf0vvz4 24 26 and and CC cord-269992-ruf0vvz4 24 27 better well JJR cord-269992-ruf0vvz4 24 28 safety safety NN cord-269992-ruf0vvz4 24 29 with with IN cord-269992-ruf0vvz4 24 30 high high JJ cord-269992-ruf0vvz4 24 31 scalability scalability NN cord-269992-ruf0vvz4 24 32 without without IN cord-269992-ruf0vvz4 24 33 harm harm NN cord-269992-ruf0vvz4 24 34 with with IN cord-269992-ruf0vvz4 24 35 any any DT cord-269992-ruf0vvz4 24 36 pathogenic pathogenic JJ cord-269992-ruf0vvz4 24 37 infections infection NNS cord-269992-ruf0vvz4 24 38 . . . cord-269992-ruf0vvz4 25 1 This this DT cord-269992-ruf0vvz4 25 2 is be VBZ cord-269992-ruf0vvz4 25 3 the the DT cord-269992-ruf0vvz4 25 4 most most RBS cord-269992-ruf0vvz4 25 5 recent recent JJ cord-269992-ruf0vvz4 25 6 and and CC cord-269992-ruf0vvz4 25 7 alternative alternative JJ cord-269992-ruf0vvz4 25 8 technology technology NN cord-269992-ruf0vvz4 25 9 for for IN cord-269992-ruf0vvz4 25 10 vaccine vaccine NN cord-269992-ruf0vvz4 25 11 development development NN cord-269992-ruf0vvz4 25 12 . . . cord-269992-ruf0vvz4 26 1 The the DT cord-269992-ruf0vvz4 26 2 expected expected JJ cord-269992-ruf0vvz4 26 3 protein protein NN cord-269992-ruf0vvz4 26 4 folding folding NN cord-269992-ruf0vvz4 26 5 and and CC cord-269992-ruf0vvz4 26 6 post post JJ cord-269992-ruf0vvz4 26 7 - - JJ cord-269992-ruf0vvz4 26 8 translational translational JJ cord-269992-ruf0vvz4 26 9 modifications modification NNS cord-269992-ruf0vvz4 26 10 of of IN cord-269992-ruf0vvz4 26 11 the the DT cord-269992-ruf0vvz4 26 12 proteins protein NNS cord-269992-ruf0vvz4 26 13 can can MD cord-269992-ruf0vvz4 26 14 be be VB cord-269992-ruf0vvz4 26 15 produced produce VBN cord-269992-ruf0vvz4 26 16 in in IN cord-269992-ruf0vvz4 26 17 the the DT cord-269992-ruf0vvz4 26 18 correct correct JJ cord-269992-ruf0vvz4 26 19 form form NN cord-269992-ruf0vvz4 26 20 in in IN cord-269992-ruf0vvz4 26 21 plant plant NN cord-269992-ruf0vvz4 26 22 - - HYPH cord-269992-ruf0vvz4 26 23 based base VBN cord-269992-ruf0vvz4 26 24 systems system NNS cord-269992-ruf0vvz4 26 25 with with IN cord-269992-ruf0vvz4 26 26 the the DT cord-269992-ruf0vvz4 26 27 desired desire VBN cord-269992-ruf0vvz4 26 28 biological biological JJ cord-269992-ruf0vvz4 26 29 functions function NNS cord-269992-ruf0vvz4 26 30 [ [ -LRB- cord-269992-ruf0vvz4 26 31 3 3 CD cord-269992-ruf0vvz4 26 32 ] ] -RRB- cord-269992-ruf0vvz4 26 33 . . . cord-269992-ruf0vvz4 27 1 Plant plant NN cord-269992-ruf0vvz4 27 2 - - HYPH cord-269992-ruf0vvz4 27 3 based base VBN cord-269992-ruf0vvz4 27 4 edible edible JJ cord-269992-ruf0vvz4 27 5 vaccines vaccine NNS cord-269992-ruf0vvz4 27 6 have have VBP cord-269992-ruf0vvz4 27 7 been be VBN cord-269992-ruf0vvz4 27 8 recently recently RB cord-269992-ruf0vvz4 27 9 introduced introduce VBN cord-269992-ruf0vvz4 27 10 for for IN cord-269992-ruf0vvz4 27 11 vaccine vaccine NN cord-269992-ruf0vvz4 27 12 production production NN cord-269992-ruf0vvz4 27 13 . . . cord-269992-ruf0vvz4 28 1 The the DT cord-269992-ruf0vvz4 28 2 main main JJ cord-269992-ruf0vvz4 28 3 goals goal NNS cord-269992-ruf0vvz4 28 4 of of IN cord-269992-ruf0vvz4 28 5 plant plant NN cord-269992-ruf0vvz4 28 6 - - HYPH cord-269992-ruf0vvz4 28 7 based base VBN cord-269992-ruf0vvz4 28 8 edible edible JJ cord-269992-ruf0vvz4 28 9 vaccines vaccine NNS cord-269992-ruf0vvz4 28 10 are be VBP cord-269992-ruf0vvz4 28 11 the the DT cord-269992-ruf0vvz4 28 12 transformation transformation NN cord-269992-ruf0vvz4 28 13 and and CC cord-269992-ruf0vvz4 28 14 production production NN cord-269992-ruf0vvz4 28 15 of of IN cord-269992-ruf0vvz4 28 16 antigens antigen NNS cord-269992-ruf0vvz4 28 17 into into IN cord-269992-ruf0vvz4 28 18 plants plant NNS cord-269992-ruf0vvz4 28 19 and and CC cord-269992-ruf0vvz4 28 20 the the DT cord-269992-ruf0vvz4 28 21 oral oral JJ cord-269992-ruf0vvz4 28 22 consumption consumption NN cord-269992-ruf0vvz4 28 23 of of IN cord-269992-ruf0vvz4 28 24 such such JJ cord-269992-ruf0vvz4 28 25 vaccine vaccine NN cord-269992-ruf0vvz4 28 26 to to TO cord-269992-ruf0vvz4 28 27 induce induce VB cord-269992-ruf0vvz4 28 28 antigen antigen NN cord-269992-ruf0vvz4 28 29 specific specific JJ cord-269992-ruf0vvz4 28 30 immune immune JJ cord-269992-ruf0vvz4 28 31 responses response NNS cord-269992-ruf0vvz4 28 32 . . . cord-269992-ruf0vvz4 29 1 Currently currently RB cord-269992-ruf0vvz4 29 2 , , , cord-269992-ruf0vvz4 29 3 the the DT cord-269992-ruf0vvz4 29 4 use use NN cord-269992-ruf0vvz4 29 5 of of IN cord-269992-ruf0vvz4 29 6 plant plant NN cord-269992-ruf0vvz4 29 7 - - HYPH cord-269992-ruf0vvz4 29 8 based base VBN cord-269992-ruf0vvz4 29 9 expression expression NN cord-269992-ruf0vvz4 29 10 system system NN cord-269992-ruf0vvz4 29 11 platform platform NN cord-269992-ruf0vvz4 29 12 have have VBP cord-269992-ruf0vvz4 29 13 been be VBN cord-269992-ruf0vvz4 29 14 extensively extensively RB cord-269992-ruf0vvz4 29 15 utilized utilize VBN cord-269992-ruf0vvz4 29 16 for for IN cord-269992-ruf0vvz4 29 17 the the DT cord-269992-ruf0vvz4 29 18 expression expression NN cord-269992-ruf0vvz4 29 19 and and CC cord-269992-ruf0vvz4 29 20 purification purification NN cord-269992-ruf0vvz4 29 21 of of IN cord-269992-ruf0vvz4 29 22 vaccines vaccine NNS cord-269992-ruf0vvz4 29 23 , , , cord-269992-ruf0vvz4 29 24 recombinant recombinant JJ cord-269992-ruf0vvz4 29 25 proteins protein NNS cord-269992-ruf0vvz4 29 26 , , , cord-269992-ruf0vvz4 29 27 enzymes enzyme NNS cord-269992-ruf0vvz4 29 28 , , , cord-269992-ruf0vvz4 29 29 and and CC cord-269992-ruf0vvz4 29 30 many many JJ cord-269992-ruf0vvz4 29 31 bio bio JJ cord-269992-ruf0vvz4 29 32 - - HYPH cord-269992-ruf0vvz4 29 33 pharmaceuticals pharmaceutical NNS cord-269992-ruf0vvz4 29 34 in in IN cord-269992-ruf0vvz4 29 35 a a DT cord-269992-ruf0vvz4 29 36 variety variety NN cord-269992-ruf0vvz4 29 37 of of IN cord-269992-ruf0vvz4 29 38 plant plant NN cord-269992-ruf0vvz4 29 39 species specie NNS cord-269992-ruf0vvz4 29 40 , , , cord-269992-ruf0vvz4 29 41 including include VBG cord-269992-ruf0vvz4 29 42 potato potato NN cord-269992-ruf0vvz4 29 43 , , , cord-269992-ruf0vvz4 29 44 corn corn NN cord-269992-ruf0vvz4 29 45 , , , cord-269992-ruf0vvz4 29 46 tomato tomato NN cord-269992-ruf0vvz4 29 47 , , , cord-269992-ruf0vvz4 29 48 carrot carrot NN cord-269992-ruf0vvz4 29 49 , , , cord-269992-ruf0vvz4 29 50 lettuce lettuce NN cord-269992-ruf0vvz4 29 51 , , , cord-269992-ruf0vvz4 29 52 and and CC cord-269992-ruf0vvz4 29 53 spinach spinach NN cord-269992-ruf0vvz4 29 54 and and CC cord-269992-ruf0vvz4 29 55 have have VBP cord-269992-ruf0vvz4 29 56 reached reach VBN cord-269992-ruf0vvz4 29 57 at at IN cord-269992-ruf0vvz4 29 58 advanced advanced JJ cord-269992-ruf0vvz4 29 59 stage stage NN cord-269992-ruf0vvz4 29 60 of of IN cord-269992-ruf0vvz4 29 61 pre pre JJ cord-269992-ruf0vvz4 29 62 - - JJ cord-269992-ruf0vvz4 29 63 clinical clinical JJ cord-269992-ruf0vvz4 29 64 and and CC cord-269992-ruf0vvz4 29 65 clinical clinical JJ cord-269992-ruf0vvz4 29 66 evaluation evaluation NN cord-269992-ruf0vvz4 29 67 . . . cord-269992-ruf0vvz4 30 1 The the DT cord-269992-ruf0vvz4 30 2 oral oral JJ cord-269992-ruf0vvz4 30 3 administration administration NN cord-269992-ruf0vvz4 30 4 of of IN cord-269992-ruf0vvz4 30 5 edible edible JJ cord-269992-ruf0vvz4 30 6 vaccines vaccine NNS cord-269992-ruf0vvz4 30 7 is be VBZ cord-269992-ruf0vvz4 30 8 a a DT cord-269992-ruf0vvz4 30 9 preferable preferable JJ cord-269992-ruf0vvz4 30 10 route route NN cord-269992-ruf0vvz4 30 11 of of IN cord-269992-ruf0vvz4 30 12 vaccination vaccination NN cord-269992-ruf0vvz4 30 13 for for IN cord-269992-ruf0vvz4 30 14 being be VBG cord-269992-ruf0vvz4 30 15 a a DT cord-269992-ruf0vvz4 30 16 simple simple JJ cord-269992-ruf0vvz4 30 17 and and CC cord-269992-ruf0vvz4 30 18 safe safe JJ cord-269992-ruf0vvz4 30 19 route route NN cord-269992-ruf0vvz4 30 20 of of IN cord-269992-ruf0vvz4 30 21 administration administration NN cord-269992-ruf0vvz4 30 22 ; ; : cord-269992-ruf0vvz4 30 23 the the DT cord-269992-ruf0vvz4 30 24 low low JJ cord-269992-ruf0vvz4 30 25 production production NN cord-269992-ruf0vvz4 30 26 cost cost NN cord-269992-ruf0vvz4 30 27 allows allow VBZ cord-269992-ruf0vvz4 30 28 for for IN cord-269992-ruf0vvz4 30 29 local local JJ cord-269992-ruf0vvz4 30 30 production production NN cord-269992-ruf0vvz4 30 31 and and CC cord-269992-ruf0vvz4 30 32 minimal minimal JJ cord-269992-ruf0vvz4 30 33 plant plant NN cord-269992-ruf0vvz4 30 34 material material NN cord-269992-ruf0vvz4 30 35 processing processing NN cord-269992-ruf0vvz4 30 36 ; ; : cord-269992-ruf0vvz4 30 37 natural natural JJ cord-269992-ruf0vvz4 30 38 bio bio JJ cord-269992-ruf0vvz4 30 39 - - HYPH cord-269992-ruf0vvz4 30 40 encapsulation encapsulation NN cord-269992-ruf0vvz4 30 41 and and CC cord-269992-ruf0vvz4 30 42 hence hence RB cord-269992-ruf0vvz4 30 43 , , , cord-269992-ruf0vvz4 30 44 stability stability NN cord-269992-ruf0vvz4 30 45 in in IN cord-269992-ruf0vvz4 30 46 the the DT cord-269992-ruf0vvz4 30 47 gastrointestinal gastrointestinal JJ cord-269992-ruf0vvz4 30 48 ( ( -LRB- cord-269992-ruf0vvz4 30 49 GI GI NNP cord-269992-ruf0vvz4 30 50 ) ) -RRB- cord-269992-ruf0vvz4 30 51 tract tract NN cord-269992-ruf0vvz4 30 52 ; ; : cord-269992-ruf0vvz4 30 53 and and CC cord-269992-ruf0vvz4 30 54 protective protective JJ cord-269992-ruf0vvz4 30 55 immunogenicity immunogenicity NN cord-269992-ruf0vvz4 30 56 at at IN cord-269992-ruf0vvz4 30 57 the the DT cord-269992-ruf0vvz4 30 58 GI GI NNP cord-269992-ruf0vvz4 30 59 mucosa mucosa NN cord-269992-ruf0vvz4 30 60 . . . cord-269992-ruf0vvz4 31 1 The the DT cord-269992-ruf0vvz4 31 2 current current JJ cord-269992-ruf0vvz4 31 3 status status NN cord-269992-ruf0vvz4 31 4 of of IN cord-269992-ruf0vvz4 31 5 plant plant NN cord-269992-ruf0vvz4 31 6 - - HYPH cord-269992-ruf0vvz4 31 7 based base VBN cord-269992-ruf0vvz4 31 8 vaccine vaccine NN cord-269992-ruf0vvz4 31 9 and and CC cord-269992-ruf0vvz4 31 10 their -PRON- PRP$ cord-269992-ruf0vvz4 31 11 clinical clinical JJ cord-269992-ruf0vvz4 31 12 evaluation evaluation NN cord-269992-ruf0vvz4 31 13 are be VBP cord-269992-ruf0vvz4 31 14 summarized summarize VBN cord-269992-ruf0vvz4 31 15 in in IN cord-269992-ruf0vvz4 31 16 Table Table NNP cord-269992-ruf0vvz4 31 17 1 1 CD cord-269992-ruf0vvz4 31 18 [ [ -LRB- cord-269992-ruf0vvz4 31 19 4 4 CD cord-269992-ruf0vvz4 31 20 , , , cord-269992-ruf0vvz4 31 21 5 5 CD cord-269992-ruf0vvz4 31 22 ] ] -RRB- cord-269992-ruf0vvz4 31 23 . . . cord-269992-ruf0vvz4 32 1 The the DT cord-269992-ruf0vvz4 32 2 plant plant NN cord-269992-ruf0vvz4 32 3 - - HYPH cord-269992-ruf0vvz4 32 4 based base VBN cord-269992-ruf0vvz4 32 5 vaccine vaccine NN cord-269992-ruf0vvz4 32 6 development development NN cord-269992-ruf0vvz4 32 7 idea idea NN cord-269992-ruf0vvz4 32 8 was be VBD cord-269992-ruf0vvz4 32 9 started start VBN cord-269992-ruf0vvz4 32 10 30 30 CD cord-269992-ruf0vvz4 32 11 years year NNS cord-269992-ruf0vvz4 32 12 ago ago RB cord-269992-ruf0vvz4 32 13 and and CC cord-269992-ruf0vvz4 32 14 since since IN cord-269992-ruf0vvz4 32 15 then then RB cord-269992-ruf0vvz4 32 16 many many JJ cord-269992-ruf0vvz4 32 17 vaccine vaccine NN cord-269992-ruf0vvz4 32 18 proteins protein NNS cord-269992-ruf0vvz4 32 19 have have VBP cord-269992-ruf0vvz4 32 20 been be VBN cord-269992-ruf0vvz4 32 21 produced produce VBN cord-269992-ruf0vvz4 32 22 in in IN cord-269992-ruf0vvz4 32 23 plants plant NNS cord-269992-ruf0vvz4 32 24 for for IN cord-269992-ruf0vvz4 32 25 human human JJ cord-269992-ruf0vvz4 32 26 and and CC cord-269992-ruf0vvz4 32 27 animal animal NN cord-269992-ruf0vvz4 32 28 diseases disease NNS cord-269992-ruf0vvz4 32 29 [ [ -LRB- cord-269992-ruf0vvz4 32 30 6 6 CD cord-269992-ruf0vvz4 32 31 ] ] -RRB- cord-269992-ruf0vvz4 33 1 [ [ -LRB- cord-269992-ruf0vvz4 33 2 7 7 CD cord-269992-ruf0vvz4 33 3 ] ] -RRB- cord-269992-ruf0vvz4 33 4 [ [ -LRB- cord-269992-ruf0vvz4 33 5 8 8 CD cord-269992-ruf0vvz4 33 6 ] ] -RRB- cord-269992-ruf0vvz4 33 7 [ [ -LRB- cord-269992-ruf0vvz4 33 8 9 9 CD cord-269992-ruf0vvz4 33 9 ] ] -RRB- cord-269992-ruf0vvz4 33 10 [ [ -LRB- cord-269992-ruf0vvz4 33 11 10 10 CD cord-269992-ruf0vvz4 33 12 ] ] -RRB- cord-269992-ruf0vvz4 33 13 . . . cord-269992-ruf0vvz4 34 1 Since since IN cord-269992-ruf0vvz4 34 2 more more JJR cord-269992-ruf0vvz4 34 3 than than IN cord-269992-ruf0vvz4 34 4 20 20 CD cord-269992-ruf0vvz4 34 5 years year NNS cord-269992-ruf0vvz4 34 6 , , , cord-269992-ruf0vvz4 34 7 plant plant NN cord-269992-ruf0vvz4 34 8 science science NN cord-269992-ruf0vvz4 34 9 has have VBZ cord-269992-ruf0vvz4 34 10 grown grow VBN cord-269992-ruf0vvz4 34 11 tremendously tremendously RB cord-269992-ruf0vvz4 34 12 and and CC cord-269992-ruf0vvz4 34 13 shown show VBN cord-269992-ruf0vvz4 34 14 great great JJ cord-269992-ruf0vvz4 34 15 importance importance NN cord-269992-ruf0vvz4 34 16 towards towards IN cord-269992-ruf0vvz4 34 17 molecular molecular JJ cord-269992-ruf0vvz4 34 18 pharming pharming NN cord-269992-ruf0vvz4 34 19 and and CC cord-269992-ruf0vvz4 34 20 have have VBP cord-269992-ruf0vvz4 34 21 significant significant JJ cord-269992-ruf0vvz4 34 22 achievements achievement NNS cord-269992-ruf0vvz4 34 23 in in IN cord-269992-ruf0vvz4 34 24 large large JJ cord-269992-ruf0vvz4 34 25 scale scale NN cord-269992-ruf0vvz4 34 26 with with IN cord-269992-ruf0vvz4 34 27 low low JJ cord-269992-ruf0vvz4 34 28 cost cost NN cord-269992-ruf0vvz4 34 29 production production NN cord-269992-ruf0vvz4 34 30 of of IN cord-269992-ruf0vvz4 34 31 recombinant recombinant JJ cord-269992-ruf0vvz4 34 32 proteins protein NNS cord-269992-ruf0vvz4 34 33 , , , cord-269992-ruf0vvz4 34 34 enzymes enzyme NNS cord-269992-ruf0vvz4 34 35 , , , cord-269992-ruf0vvz4 34 36 and and CC cord-269992-ruf0vvz4 34 37 pharmaceuticals pharmaceutical NNS cord-269992-ruf0vvz4 34 38 compounds compound NNS cord-269992-ruf0vvz4 34 39 . . . cord-269992-ruf0vvz4 35 1 Currently currently RB cord-269992-ruf0vvz4 35 2 , , , cord-269992-ruf0vvz4 35 3 various various JJ cord-269992-ruf0vvz4 35 4 pharmaceutical pharmaceutical JJ cord-269992-ruf0vvz4 35 5 compounds compound NNS cord-269992-ruf0vvz4 35 6 , , , cord-269992-ruf0vvz4 35 7 antigen antigen NN cord-269992-ruf0vvz4 35 8 , , , cord-269992-ruf0vvz4 35 9 antibodies antibody NNS cord-269992-ruf0vvz4 35 10 , , , cord-269992-ruf0vvz4 35 11 hormones hormone NNS cord-269992-ruf0vvz4 35 12 , , , cord-269992-ruf0vvz4 35 13 enzymes enzyme NNS cord-269992-ruf0vvz4 35 14 , , , cord-269992-ruf0vvz4 35 15 and and CC cord-269992-ruf0vvz4 35 16 growth growth NN cord-269992-ruf0vvz4 35 17 regulators regulator NNS cord-269992-ruf0vvz4 35 18 have have VBP cord-269992-ruf0vvz4 35 19 been be VBN cord-269992-ruf0vvz4 35 20 developed develop VBN cord-269992-ruf0vvz4 35 21 into into IN cord-269992-ruf0vvz4 35 22 multiple multiple JJ cord-269992-ruf0vvz4 35 23 plants plant NNS cord-269992-ruf0vvz4 35 24 system system NN cord-269992-ruf0vvz4 35 25 [ [ -LRB- cord-269992-ruf0vvz4 35 26 10 10 CD cord-269992-ruf0vvz4 35 27 ] ] -RRB- cord-269992-ruf0vvz4 35 28 [ [ -LRB- cord-269992-ruf0vvz4 35 29 11 11 CD cord-269992-ruf0vvz4 35 30 ] ] -RRB- cord-269992-ruf0vvz4 35 31 [ [ -LRB- cord-269992-ruf0vvz4 35 32 12 12 CD cord-269992-ruf0vvz4 35 33 ] ] -RRB- cord-269992-ruf0vvz4 35 34 [ [ -LRB- cord-269992-ruf0vvz4 35 35 13 13 CD cord-269992-ruf0vvz4 35 36 ] ] -RRB- cord-269992-ruf0vvz4 35 37 . . . cord-269992-ruf0vvz4 36 1 The the DT cord-269992-ruf0vvz4 36 2 main main JJ cord-269992-ruf0vvz4 36 3 objective objective NN cord-269992-ruf0vvz4 36 4 of of IN cord-269992-ruf0vvz4 36 5 this this DT cord-269992-ruf0vvz4 36 6 review review NN cord-269992-ruf0vvz4 36 7 is be VBZ cord-269992-ruf0vvz4 36 8 to to TO cord-269992-ruf0vvz4 36 9 provide provide VB cord-269992-ruf0vvz4 36 10 the the DT cord-269992-ruf0vvz4 36 11 latest late JJS cord-269992-ruf0vvz4 36 12 information information NN cord-269992-ruf0vvz4 36 13 about about IN cord-269992-ruf0vvz4 36 14 the the DT cord-269992-ruf0vvz4 36 15 use use NN cord-269992-ruf0vvz4 36 16 of of IN cord-269992-ruf0vvz4 36 17 plant plant NN cord-269992-ruf0vvz4 36 18 - - HYPH cord-269992-ruf0vvz4 36 19 based base VBN cord-269992-ruf0vvz4 36 20 platform platform NN cord-269992-ruf0vvz4 36 21 for for IN cord-269992-ruf0vvz4 36 22 the the DT cord-269992-ruf0vvz4 36 23 development development NN cord-269992-ruf0vvz4 36 24 of of IN cord-269992-ruf0vvz4 36 25 an an DT cord-269992-ruf0vvz4 36 26 edible edible JJ cord-269992-ruf0vvz4 36 27 vaccine vaccine NN cord-269992-ruf0vvz4 36 28 . . . cord-269992-ruf0vvz4 36 29 _SP cord-269992-ruf0vvz4 37 1 For for IN cord-269992-ruf0vvz4 37 2 plant plant NN cord-269992-ruf0vvz4 37 3 - - HYPH cord-269992-ruf0vvz4 37 4 based base VBN cord-269992-ruf0vvz4 37 5 vaccine vaccine NN cord-269992-ruf0vvz4 37 6 development development NN cord-269992-ruf0vvz4 37 7 , , , cord-269992-ruf0vvz4 37 8 the the DT cord-269992-ruf0vvz4 37 9 desired desire VBN cord-269992-ruf0vvz4 37 10 plant plant NN cord-269992-ruf0vvz4 37 11 with with IN cord-269992-ruf0vvz4 37 12 efficient efficient JJ cord-269992-ruf0vvz4 37 13 and and CC cord-269992-ruf0vvz4 37 14 quick quick JJ cord-269992-ruf0vvz4 37 15 regeneration regeneration NN cord-269992-ruf0vvz4 37 16 and and CC cord-269992-ruf0vvz4 37 17 transformation transformation NN cord-269992-ruf0vvz4 37 18 properties property NNS cord-269992-ruf0vvz4 37 19 should should MD cord-269992-ruf0vvz4 37 20 be be VB cord-269992-ruf0vvz4 37 21 selected select VBN cord-269992-ruf0vvz4 37 22 . . . cord-269992-ruf0vvz4 38 1 The the DT cord-269992-ruf0vvz4 38 2 desired desire VBN cord-269992-ruf0vvz4 38 3 gene gene NN cord-269992-ruf0vvz4 38 4 can can MD cord-269992-ruf0vvz4 38 5 be be VB cord-269992-ruf0vvz4 38 6 delivered deliver VBN cord-269992-ruf0vvz4 38 7 into into IN cord-269992-ruf0vvz4 38 8 plant plant NN cord-269992-ruf0vvz4 38 9 cells cell NNS cord-269992-ruf0vvz4 38 10 to to TO cord-269992-ruf0vvz4 38 11 express express VB cord-269992-ruf0vvz4 38 12 desired desired JJ cord-269992-ruf0vvz4 38 13 proteins protein NNS cord-269992-ruf0vvz4 38 14 / / SYM cord-269992-ruf0vvz4 38 15 pharmaceuticals pharmaceutical NNS cord-269992-ruf0vvz4 38 16 compounds compound NNS cord-269992-ruf0vvz4 38 17 with with IN cord-269992-ruf0vvz4 38 18 low low JJ cord-269992-ruf0vvz4 38 19 cost cost NN cord-269992-ruf0vvz4 38 20 and and CC cord-269992-ruf0vvz4 38 21 high high JJ cord-269992-ruf0vvz4 38 22 scale scale NN cord-269992-ruf0vvz4 38 23 [ [ -LRB- cord-269992-ruf0vvz4 38 24 5 5 CD cord-269992-ruf0vvz4 38 25 , , , cord-269992-ruf0vvz4 38 26 6 6 CD cord-269992-ruf0vvz4 38 27 , , , cord-269992-ruf0vvz4 38 28 9 9 CD cord-269992-ruf0vvz4 38 29 ] ] -RRB- cord-269992-ruf0vvz4 38 30 . . . cord-269992-ruf0vvz4 39 1 This this DT cord-269992-ruf0vvz4 39 2 technology technology NN cord-269992-ruf0vvz4 39 3 has have VBZ cord-269992-ruf0vvz4 39 4 attracted attract VBN cord-269992-ruf0vvz4 39 5 the the DT cord-269992-ruf0vvz4 39 6 researchers researcher NNS cord-269992-ruf0vvz4 39 7 because because IN cord-269992-ruf0vvz4 39 8 of of IN cord-269992-ruf0vvz4 39 9 elimination elimination NN cord-269992-ruf0vvz4 39 10 of of IN cord-269992-ruf0vvz4 39 11 a a DT cord-269992-ruf0vvz4 39 12 specific specific JJ cord-269992-ruf0vvz4 39 13 animal animal NN cord-269992-ruf0vvz4 39 14 requirement requirement NN cord-269992-ruf0vvz4 39 15 to to TO cord-269992-ruf0vvz4 39 16 conduct conduct VB cord-269992-ruf0vvz4 39 17 the the DT cord-269992-ruf0vvz4 39 18 experiment experiment NN cord-269992-ruf0vvz4 39 19 . . . cord-269992-ruf0vvz4 40 1 The the DT cord-269992-ruf0vvz4 40 2 edible edible JJ cord-269992-ruf0vvz4 40 3 vaccines vaccine NNS cord-269992-ruf0vvz4 40 4 can can MD cord-269992-ruf0vvz4 40 5 be be VB cord-269992-ruf0vvz4 40 6 designed design VBN cord-269992-ruf0vvz4 40 7 in in IN cord-269992-ruf0vvz4 40 8 such such PDT cord-269992-ruf0vvz4 40 9 a a DT cord-269992-ruf0vvz4 40 10 way way NN cord-269992-ruf0vvz4 40 11 that that WDT cord-269992-ruf0vvz4 40 12 , , , cord-269992-ruf0vvz4 40 13 the the DT cord-269992-ruf0vvz4 40 14 expressed express VBN cord-269992-ruf0vvz4 40 15 and and CC cord-269992-ruf0vvz4 40 16 produced produce VBN cord-269992-ruf0vvz4 40 17 proteins protein NNS cord-269992-ruf0vvz4 40 18 should should MD cord-269992-ruf0vvz4 40 19 not not RB cord-269992-ruf0vvz4 40 20 be be VB cord-269992-ruf0vvz4 40 21 pathogenic pathogenic JJ cord-269992-ruf0vvz4 40 22 . . . cord-269992-ruf0vvz4 41 1 The the DT cord-269992-ruf0vvz4 41 2 production production NN cord-269992-ruf0vvz4 41 3 of of IN cord-269992-ruf0vvz4 41 4 conventional conventional JJ cord-269992-ruf0vvz4 41 5 vaccines vaccine NNS cord-269992-ruf0vvz4 41 6 is be VBZ cord-269992-ruf0vvz4 41 7 very very RB cord-269992-ruf0vvz4 41 8 expensive expensive JJ cord-269992-ruf0vvz4 41 9 , , , cord-269992-ruf0vvz4 41 10 and and CC cord-269992-ruf0vvz4 41 11 they -PRON- PRP cord-269992-ruf0vvz4 41 12 require require VBP cord-269992-ruf0vvz4 41 13 purification purification NN cord-269992-ruf0vvz4 41 14 and and CC cord-269992-ruf0vvz4 41 15 refrigeration refrigeration NN cord-269992-ruf0vvz4 41 16 . . . cord-269992-ruf0vvz4 42 1 Apart apart RB cord-269992-ruf0vvz4 42 2 from from IN cord-269992-ruf0vvz4 42 3 that that DT cord-269992-ruf0vvz4 42 4 , , , cord-269992-ruf0vvz4 42 5 the the DT cord-269992-ruf0vvz4 42 6 plant plant NN cord-269992-ruf0vvz4 42 7 - - HYPH cord-269992-ruf0vvz4 42 8 based base VBN cord-269992-ruf0vvz4 42 9 vaccines vaccine NNS cord-269992-ruf0vvz4 42 10 are be VBP cord-269992-ruf0vvz4 42 11 the the DT cord-269992-ruf0vvz4 42 12 most most RBS cord-269992-ruf0vvz4 42 13 suitable suitable JJ cord-269992-ruf0vvz4 42 14 for for IN cord-269992-ruf0vvz4 42 15 children child NNS cord-269992-ruf0vvz4 42 16 as as IN cord-269992-ruf0vvz4 42 17 an an DT cord-269992-ruf0vvz4 42 18 oral oral JJ cord-269992-ruf0vvz4 42 19 delivery delivery NN cord-269992-ruf0vvz4 42 20 . . . cord-269992-ruf0vvz4 43 1 Currently currently RB cord-269992-ruf0vvz4 43 2 , , , cord-269992-ruf0vvz4 43 3 World World NNP cord-269992-ruf0vvz4 43 4 Health Health NNP cord-269992-ruf0vvz4 43 5 Organization Organization NNP cord-269992-ruf0vvz4 43 6 has have VBZ cord-269992-ruf0vvz4 43 7 suggested suggest VBN cord-269992-ruf0vvz4 43 8 new new JJ cord-269992-ruf0vvz4 43 9 technologies technology NNS cord-269992-ruf0vvz4 43 10 for for IN cord-269992-ruf0vvz4 43 11 the the DT cord-269992-ruf0vvz4 43 12 vaccine vaccine NN cord-269992-ruf0vvz4 43 13 development development NN cord-269992-ruf0vvz4 43 14 . . . cord-269992-ruf0vvz4 44 1 The the DT cord-269992-ruf0vvz4 44 2 specific specific JJ cord-269992-ruf0vvz4 44 3 proteins protein NNS cord-269992-ruf0vvz4 44 4 can can MD cord-269992-ruf0vvz4 44 5 be be VB cord-269992-ruf0vvz4 44 6 expressed express VBN cord-269992-ruf0vvz4 44 7 into into IN cord-269992-ruf0vvz4 44 8 desired desire VBN cord-269992-ruf0vvz4 44 9 plants plant NNS cord-269992-ruf0vvz4 44 10 with with IN cord-269992-ruf0vvz4 44 11 very very RB cord-269992-ruf0vvz4 44 12 less less RBR cord-269992-ruf0vvz4 44 13 cost cost NN cord-269992-ruf0vvz4 44 14 and and CC cord-269992-ruf0vvz4 44 15 can can MD cord-269992-ruf0vvz4 44 16 be be VB cord-269992-ruf0vvz4 44 17 grown grow VBN cord-269992-ruf0vvz4 44 18 to to IN cord-269992-ruf0vvz4 44 19 the the DT cord-269992-ruf0vvz4 44 20 required require VBN cord-269992-ruf0vvz4 44 21 locations location NNS cord-269992-ruf0vvz4 44 22 so so IN cord-269992-ruf0vvz4 44 23 that that IN cord-269992-ruf0vvz4 44 24 , , , cord-269992-ruf0vvz4 44 25 an an DT cord-269992-ruf0vvz4 44 26 edible edible JJ cord-269992-ruf0vvz4 44 27 vaccine vaccine NN cord-269992-ruf0vvz4 44 28 can can MD cord-269992-ruf0vvz4 44 29 be be VB cord-269992-ruf0vvz4 44 30 available available JJ cord-269992-ruf0vvz4 44 31 to to IN cord-269992-ruf0vvz4 44 32 the the DT cord-269992-ruf0vvz4 44 33 needy needy JJ cord-269992-ruf0vvz4 44 34 population population NN cord-269992-ruf0vvz4 44 35 globally globally RB cord-269992-ruf0vvz4 44 36 , , , cord-269992-ruf0vvz4 44 37 especially especially RB cord-269992-ruf0vvz4 44 38 in in IN cord-269992-ruf0vvz4 44 39 the the DT cord-269992-ruf0vvz4 44 40 developing develop VBG cord-269992-ruf0vvz4 44 41 countries country NNS cord-269992-ruf0vvz4 44 42 . . . cord-269992-ruf0vvz4 45 1 Due due IN cord-269992-ruf0vvz4 45 2 to to IN cord-269992-ruf0vvz4 45 3 high high JJ cord-269992-ruf0vvz4 45 4 cost cost NN cord-269992-ruf0vvz4 45 5 , , , cord-269992-ruf0vvz4 45 6 storage storage NN cord-269992-ruf0vvz4 45 7 , , , cord-269992-ruf0vvz4 45 8 refrigeration refrigeration NN cord-269992-ruf0vvz4 45 9 , , , cord-269992-ruf0vvz4 45 10 transportation transportation NN cord-269992-ruf0vvz4 45 11 , , , cord-269992-ruf0vvz4 45 12 and and CC cord-269992-ruf0vvz4 45 13 requirements requirement NNS cord-269992-ruf0vvz4 45 14 of of IN cord-269992-ruf0vvz4 45 15 trained train VBN cord-269992-ruf0vvz4 45 16 medical medical JJ cord-269992-ruf0vvz4 45 17 personnel personnel NNS cord-269992-ruf0vvz4 45 18 , , , cord-269992-ruf0vvz4 45 19 an an DT cord-269992-ruf0vvz4 45 20 injectable injectable JJ cord-269992-ruf0vvz4 45 21 vaccine vaccine NN cord-269992-ruf0vvz4 45 22 can can MD cord-269992-ruf0vvz4 45 23 not not RB cord-269992-ruf0vvz4 45 24 be be VB cord-269992-ruf0vvz4 45 25 easily easily RB cord-269992-ruf0vvz4 45 26 taken take VBN cord-269992-ruf0vvz4 45 27 in in IN cord-269992-ruf0vvz4 45 28 developing develop VBG cord-269992-ruf0vvz4 45 29 countries country NNS cord-269992-ruf0vvz4 45 30 . . . cord-269992-ruf0vvz4 46 1 Additionally additionally RB cord-269992-ruf0vvz4 46 2 , , , cord-269992-ruf0vvz4 46 3 various various JJ cord-269992-ruf0vvz4 46 4 pathogenic pathogenic JJ cord-269992-ruf0vvz4 46 5 organism organism NN cord-269992-ruf0vvz4 46 6 , , , cord-269992-ruf0vvz4 46 7 bacterial bacterial JJ cord-269992-ruf0vvz4 46 8 and and CC cord-269992-ruf0vvz4 46 9 viral viral JJ cord-269992-ruf0vvz4 46 10 diseases disease NNS cord-269992-ruf0vvz4 46 11 can can MD cord-269992-ruf0vvz4 46 12 be be VB cord-269992-ruf0vvz4 46 13 easily easily RB cord-269992-ruf0vvz4 46 14 transmitted transmit VBN cord-269992-ruf0vvz4 46 15 by by IN cord-269992-ruf0vvz4 46 16 re re NN cord-269992-ruf0vvz4 46 17 - - NN cord-269992-ruf0vvz4 46 18 use use NN cord-269992-ruf0vvz4 46 19 of of IN cord-269992-ruf0vvz4 46 20 needles needle NNS cord-269992-ruf0vvz4 46 21 . . . cord-269992-ruf0vvz4 47 1 Mono mono JJ cord-269992-ruf0vvz4 47 2 - - HYPH cord-269992-ruf0vvz4 47 3 clonal clonal JJ cord-269992-ruf0vvz4 47 4 antibodies antibody NNS cord-269992-ruf0vvz4 47 5 are be VBP cord-269992-ruf0vvz4 47 6 being be VBG cord-269992-ruf0vvz4 47 7 used use VBN cord-269992-ruf0vvz4 47 8 in in IN cord-269992-ruf0vvz4 47 9 the the DT cord-269992-ruf0vvz4 47 10 treatment treatment NN cord-269992-ruf0vvz4 47 11 of of IN cord-269992-ruf0vvz4 47 12 arthritis arthritis NN cord-269992-ruf0vvz4 47 13 and and CC cord-269992-ruf0vvz4 47 14 cancer cancer NN cord-269992-ruf0vvz4 47 15 . . . cord-269992-ruf0vvz4 48 1 The the DT cord-269992-ruf0vvz4 48 2 monoclonal monoclonal JJ cord-269992-ruf0vvz4 48 3 antibodies antibody NNS cord-269992-ruf0vvz4 48 4 can can MD cord-269992-ruf0vvz4 48 5 be be VB cord-269992-ruf0vvz4 48 6 easily easily RB cord-269992-ruf0vvz4 48 7 produced produce VBN cord-269992-ruf0vvz4 48 8 in in IN cord-269992-ruf0vvz4 48 9 desired desire VBN cord-269992-ruf0vvz4 48 10 transgenic transgenic JJ cord-269992-ruf0vvz4 48 11 plants plant NNS cord-269992-ruf0vvz4 48 12 with with IN cord-269992-ruf0vvz4 48 13 very very RB cord-269992-ruf0vvz4 48 14 less less RBR cord-269992-ruf0vvz4 48 15 cost cost NN cord-269992-ruf0vvz4 48 16 and and CC cord-269992-ruf0vvz4 48 17 time time NN cord-269992-ruf0vvz4 48 18 duration duration NN cord-269992-ruf0vvz4 48 19 . . . cord-269992-ruf0vvz4 49 1 It -PRON- PRP cord-269992-ruf0vvz4 49 2 has have VBZ cord-269992-ruf0vvz4 49 3 been be VBN cord-269992-ruf0vvz4 49 4 reported report VBN cord-269992-ruf0vvz4 49 5 that that IN cord-269992-ruf0vvz4 49 6 the the DT cord-269992-ruf0vvz4 49 7 developed develop VBN cord-269992-ruf0vvz4 49 8 transgenic transgenic JJ cord-269992-ruf0vvz4 49 9 rice rice NN cord-269992-ruf0vvz4 49 10 was be VBD cord-269992-ruf0vvz4 49 11 stable stable JJ cord-269992-ruf0vvz4 49 12 at at IN cord-269992-ruf0vvz4 49 13 room room NN cord-269992-ruf0vvz4 49 14 temperature temperature NN cord-269992-ruf0vvz4 49 15 for for IN cord-269992-ruf0vvz4 49 16 18 18 CD cord-269992-ruf0vvz4 49 17 months month NNS cord-269992-ruf0vvz4 49 18 . . . cord-269992-ruf0vvz4 50 1 Because because IN cord-269992-ruf0vvz4 50 2 these these DT cord-269992-ruf0vvz4 50 3 vaccines vaccine NNS cord-269992-ruf0vvz4 50 4 are be VBP cord-269992-ruf0vvz4 50 5 needle needle NN cord-269992-ruf0vvz4 50 6 - - HYPH cord-269992-ruf0vvz4 50 7 free free JJ cord-269992-ruf0vvz4 50 8 [ [ -LRB- cord-269992-ruf0vvz4 50 9 14 14 CD cord-269992-ruf0vvz4 50 10 ] ] -RRB- cord-269992-ruf0vvz4 50 11 , , , cord-269992-ruf0vvz4 50 12 they -PRON- PRP cord-269992-ruf0vvz4 50 13 have have VBP cord-269992-ruf0vvz4 50 14 the the DT cord-269992-ruf0vvz4 50 15 added add VBN cord-269992-ruf0vvz4 50 16 advantage advantage NN cord-269992-ruf0vvz4 50 17 of of IN cord-269992-ruf0vvz4 50 18 eliminating eliminate VBG cord-269992-ruf0vvz4 50 19 the the DT cord-269992-ruf0vvz4 50 20 associated associated JJ cord-269992-ruf0vvz4 50 21 waste waste NN cord-269992-ruf0vvz4 50 22 and and CC cord-269992-ruf0vvz4 50 23 potential potential NN cord-269992-ruf0vvz4 50 24 for for IN cord-269992-ruf0vvz4 50 25 dissemination dissemination NN cord-269992-ruf0vvz4 50 26 of of IN cord-269992-ruf0vvz4 50 27 blood blood NN cord-269992-ruf0vvz4 50 28 borne bear VBN cord-269992-ruf0vvz4 50 29 - - HYPH cord-269992-ruf0vvz4 50 30 infections infection NNS cord-269992-ruf0vvz4 50 31 . . . cord-269992-ruf0vvz4 51 1 Antigens antigen NNS cord-269992-ruf0vvz4 51 2 are be VBP cord-269992-ruf0vvz4 51 3 released release VBN cord-269992-ruf0vvz4 51 4 in in IN cord-269992-ruf0vvz4 51 5 the the DT cord-269992-ruf0vvz4 51 6 form form NN cord-269992-ruf0vvz4 51 7 of of IN cord-269992-ruf0vvz4 51 8 vaccine vaccine NN cord-269992-ruf0vvz4 51 9 through through IN cord-269992-ruf0vvz4 51 10 bio bio JJ cord-269992-ruf0vvz4 51 11 - - HYPH cord-269992-ruf0vvz4 51 12 encapsulation encapsulation NNP cord-269992-ruf0vvz4 51 13 which which WDT cord-269992-ruf0vvz4 51 14 protects protect VBZ cord-269992-ruf0vvz4 51 15 them -PRON- PRP cord-269992-ruf0vvz4 51 16 from from IN cord-269992-ruf0vvz4 51 17 gastric gastric JJ cord-269992-ruf0vvz4 51 18 enzymes enzyme NNS cord-269992-ruf0vvz4 51 19 . . . cord-269992-ruf0vvz4 52 1 The the DT cord-269992-ruf0vvz4 52 2 released release VBN cord-269992-ruf0vvz4 52 3 proteins protein NNS cord-269992-ruf0vvz4 52 4 were be VBD cord-269992-ruf0vvz4 52 5 absorbed absorb VBN cord-269992-ruf0vvz4 52 6 by by IN cord-269992-ruf0vvz4 52 7 M M NNP cord-269992-ruf0vvz4 52 8 cells cell NNS cord-269992-ruf0vvz4 52 9 in in IN cord-269992-ruf0vvz4 52 10 the the DT cord-269992-ruf0vvz4 52 11 intestinal intestinal JJ cord-269992-ruf0vvz4 52 12 wall wall NN cord-269992-ruf0vvz4 52 13 and and CC cord-269992-ruf0vvz4 52 14 passed pass VBD cord-269992-ruf0vvz4 52 15 on on RP cord-269992-ruf0vvz4 52 16 to to IN cord-269992-ruf0vvz4 52 17 the the DT cord-269992-ruf0vvz4 52 18 macrophages macrophage NNS cord-269992-ruf0vvz4 52 19 and and CC cord-269992-ruf0vvz4 52 20 antigen antigen NN cord-269992-ruf0vvz4 52 21 - - HYPH cord-269992-ruf0vvz4 52 22 presenting present VBG cord-269992-ruf0vvz4 52 23 cells cell NNS cord-269992-ruf0vvz4 52 24 and and CC cord-269992-ruf0vvz4 52 25 local local JJ cord-269992-ruf0vvz4 52 26 lymphocyte lymphocyte NN cord-269992-ruf0vvz4 52 27 populations population NNS cord-269992-ruf0vvz4 52 28 generating generate VBG cord-269992-ruf0vvz4 52 29 serum serum NN cord-269992-ruf0vvz4 52 30 immunoglobulin immunoglobulin NN cord-269992-ruf0vvz4 52 31 ( ( -LRB- cord-269992-ruf0vvz4 52 32 Ig)G Ig)G NNP cord-269992-ruf0vvz4 52 33 , , , cord-269992-ruf0vvz4 52 34 IgE IgE NNP cord-269992-ruf0vvz4 52 35 , , , cord-269992-ruf0vvz4 52 36 and and CC cord-269992-ruf0vvz4 52 37 local local JJ cord-269992-ruf0vvz4 52 38 IgA IgA NNP cord-269992-ruf0vvz4 52 39 responses response NNS cord-269992-ruf0vvz4 52 40 and and CC cord-269992-ruf0vvz4 52 41 memory memory NN cord-269992-ruf0vvz4 52 42 cells cell NNS cord-269992-ruf0vvz4 52 43 which which WDT cord-269992-ruf0vvz4 52 44 neutralize neutralize VBP cord-269992-ruf0vvz4 52 45 the the DT cord-269992-ruf0vvz4 52 46 attack attack NN cord-269992-ruf0vvz4 52 47 by by IN cord-269992-ruf0vvz4 52 48 a a DT cord-269992-ruf0vvz4 52 49 real real JJ cord-269992-ruf0vvz4 52 50 pathogen pathogen NN cord-269992-ruf0vvz4 52 51 . . . cord-269992-ruf0vvz4 53 1 The the DT cord-269992-ruf0vvz4 53 2 development development NN cord-269992-ruf0vvz4 53 3 and and CC cord-269992-ruf0vvz4 53 4 stability stability NN cord-269992-ruf0vvz4 53 5 of of IN cord-269992-ruf0vvz4 53 6 edible edible JJ cord-269992-ruf0vvz4 53 7 vaccine vaccine NN cord-269992-ruf0vvz4 53 8 as as IN cord-269992-ruf0vvz4 53 9 an an DT cord-269992-ruf0vvz4 53 10 antigen antigen NN cord-269992-ruf0vvz4 53 11 has have VBZ cord-269992-ruf0vvz4 53 12 been be VBN cord-269992-ruf0vvz4 53 13 investigated investigate VBN cord-269992-ruf0vvz4 53 14 in in IN cord-269992-ruf0vvz4 53 15 many many JJ cord-269992-ruf0vvz4 53 16 recent recent JJ cord-269992-ruf0vvz4 53 17 reports report NNS cord-269992-ruf0vvz4 53 18 . . . cord-269992-ruf0vvz4 54 1 The the DT cord-269992-ruf0vvz4 54 2 current current JJ cord-269992-ruf0vvz4 54 3 status status NN cord-269992-ruf0vvz4 54 4 of of IN cord-269992-ruf0vvz4 54 5 plant plant NN cord-269992-ruf0vvz4 54 6 - - HYPH cord-269992-ruf0vvz4 54 7 based base VBN cord-269992-ruf0vvz4 54 8 vaccines vaccine NNS cord-269992-ruf0vvz4 54 9 has have VBZ cord-269992-ruf0vvz4 54 10 been be VBN cord-269992-ruf0vvz4 54 11 reviewed review VBN cord-269992-ruf0vvz4 54 12 and and CC cord-269992-ruf0vvz4 54 13 presented present VBN cord-269992-ruf0vvz4 54 14 [ [ -LRB- cord-269992-ruf0vvz4 54 15 5 5 CD cord-269992-ruf0vvz4 54 16 ] ] -RRB- cord-269992-ruf0vvz4 54 17 . . . cord-269992-ruf0vvz4 55 1 The the DT cord-269992-ruf0vvz4 55 2 concept concept NN cord-269992-ruf0vvz4 55 3 of of IN cord-269992-ruf0vvz4 55 4 edible edible JJ cord-269992-ruf0vvz4 55 5 vaccine vaccine NN cord-269992-ruf0vvz4 55 6 development development NN cord-269992-ruf0vvz4 55 7 has have VBZ cord-269992-ruf0vvz4 55 8 been be VBN cord-269992-ruf0vvz4 55 9 presented present VBN cord-269992-ruf0vvz4 55 10 in in IN cord-269992-ruf0vvz4 55 11 Fig Fig NNP cord-269992-ruf0vvz4 55 12 . . . cord-269992-ruf0vvz4 56 1 1 1 LS cord-269992-ruf0vvz4 56 2 . . . cord-269992-ruf0vvz4 57 1 Currently currently RB cord-269992-ruf0vvz4 57 2 , , , cord-269992-ruf0vvz4 57 3 the the DT cord-269992-ruf0vvz4 57 4 plant plant NN cord-269992-ruf0vvz4 57 5 - - HYPH cord-269992-ruf0vvz4 57 6 based base VBN cord-269992-ruf0vvz4 57 7 vaccine vaccine NN cord-269992-ruf0vvz4 57 8 has have VBZ cord-269992-ruf0vvz4 57 9 many many JJ cord-269992-ruf0vvz4 57 10 valuable valuable JJ cord-269992-ruf0vvz4 57 11 advantages advantage NNS cord-269992-ruf0vvz4 57 12 as as IN cord-269992-ruf0vvz4 57 13 compared compare VBN cord-269992-ruf0vvz4 57 14 to to IN cord-269992-ruf0vvz4 57 15 traditional traditional JJ cord-269992-ruf0vvz4 57 16 vaccines vaccine NNS cord-269992-ruf0vvz4 57 17 which which WDT cord-269992-ruf0vvz4 57 18 include include VBP cord-269992-ruf0vvz4 57 19 . . . cord-269992-ruf0vvz4 58 1 adjuvants adjuvant NNS cord-269992-ruf0vvz4 58 2 require require VBP cord-269992-ruf0vvz4 58 3 to to TO cord-269992-ruf0vvz4 58 4 enhance enhance VB cord-269992-ruf0vvz4 58 5 immune immune JJ cord-269992-ruf0vvz4 58 6 responses response NNS cord-269992-ruf0vvz4 58 7 . . . cord-269992-ruf0vvz4 59 1 ( ( -LRB- cord-269992-ruf0vvz4 59 2 4 4 LS cord-269992-ruf0vvz4 59 3 ) ) -RRB- cord-269992-ruf0vvz4 59 4 Orallyintroduced orallyintroduce VBN cord-269992-ruf0vvz4 59 5 antigens antigen NNS cord-269992-ruf0vvz4 59 6 elicit elicit VBP cord-269992-ruf0vvz4 59 7 mucosal mucosal JJ cord-269992-ruf0vvz4 59 8 immunity immunity NN cord-269992-ruf0vvz4 59 9 . . . cord-269992-ruf0vvz4 60 1 ( ( -LRB- cord-269992-ruf0vvz4 60 2 5 5 LS cord-269992-ruf0vvz4 60 3 ) ) -RRB- cord-269992-ruf0vvz4 60 4 It -PRON- PRP cord-269992-ruf0vvz4 60 5 is be VBZ cord-269992-ruf0vvz4 60 6 easy easy JJ cord-269992-ruf0vvz4 60 7 to to TO cord-269992-ruf0vvz4 60 8 bulk bulk JJ cord-269992-ruf0vvz4 60 9 produce produce NN cord-269992-ruf0vvz4 60 10 onsite onsite JJ cord-269992-ruf0vvz4 60 11 , , , cord-269992-ruf0vvz4 60 12 transport transport NN cord-269992-ruf0vvz4 60 13 and and CC cord-269992-ruf0vvz4 60 14 stored store VBN cord-269992-ruf0vvz4 60 15 with with IN cord-269992-ruf0vvz4 60 16 less less JJR cord-269992-ruf0vvz4 60 17 cost cost NN cord-269992-ruf0vvz4 60 18 and and CC cord-269992-ruf0vvz4 60 19 without without IN cord-269992-ruf0vvz4 60 20 refrigeration refrigeration NN cord-269992-ruf0vvz4 60 21 . . . cord-269992-ruf0vvz4 61 1 ( ( -LRB- cord-269992-ruf0vvz4 61 2 6 6 CD cord-269992-ruf0vvz4 61 3 ) ) -RRB- cord-269992-ruf0vvz4 62 1 No no DT cord-269992-ruf0vvz4 62 2 injection injection NN cord-269992-ruf0vvz4 62 3 and and CC cord-269992-ruf0vvz4 62 4 need need NN cord-269992-ruf0vvz4 62 5 for for IN cord-269992-ruf0vvz4 62 6 trained train VBN cord-269992-ruf0vvz4 62 7 medical medical JJ cord-269992-ruf0vvz4 62 8 person person NN cord-269992-ruf0vvz4 62 9 . . . cord-269992-ruf0vvz4 63 1 ( ( -LRB- cord-269992-ruf0vvz4 63 2 7 7 CD cord-269992-ruf0vvz4 63 3 ) ) -RRB- cord-269992-ruf0vvz4 63 4 Easy easy JJ cord-269992-ruf0vvz4 63 5 to to TO cord-269992-ruf0vvz4 63 6 express express VB cord-269992-ruf0vvz4 63 7 , , , cord-269992-ruf0vvz4 63 8 separate separate VB cord-269992-ruf0vvz4 63 9 and and CC cord-269992-ruf0vvz4 63 10 purify purify VB cord-269992-ruf0vvz4 63 11 the the DT cord-269992-ruf0vvz4 63 12 protein protein NN cord-269992-ruf0vvz4 63 13 . . . cord-269992-ruf0vvz4 64 1 ( ( -LRB- cord-269992-ruf0vvz4 64 2 8) 8) NN cord-269992-ruf0vvz4 64 3 They -PRON- PRP cord-269992-ruf0vvz4 64 4 can can MD cord-269992-ruf0vvz4 64 5 be be VB cord-269992-ruf0vvz4 64 6 stored store VBN cord-269992-ruf0vvz4 64 7 as as IN cord-269992-ruf0vvz4 64 8 seeds seed NNS cord-269992-ruf0vvz4 64 9 and and CC cord-269992-ruf0vvz4 64 10 oils oil NNS cord-269992-ruf0vvz4 64 11 and and CC cord-269992-ruf0vvz4 64 12 dried dry VBD cord-269992-ruf0vvz4 64 13 tissue tissue NN cord-269992-ruf0vvz4 64 14 without without IN cord-269992-ruf0vvz4 64 15 any any DT cord-269992-ruf0vvz4 64 16 refrigeration refrigeration NN cord-269992-ruf0vvz4 64 17 . . . cord-269992-ruf0vvz4 65 1 ( ( -LRB- cord-269992-ruf0vvz4 65 2 9 9 LS cord-269992-ruf0vvz4 65 3 ) ) -RRB- cord-269992-ruf0vvz4 65 4 They -PRON- PRP cord-269992-ruf0vvz4 65 5 do do VBP cord-269992-ruf0vvz4 65 6 not not RB cord-269992-ruf0vvz4 65 7 have have VB cord-269992-ruf0vvz4 65 8 any any DT cord-269992-ruf0vvz4 65 9 risk risk NN cord-269992-ruf0vvz4 65 10 of of IN cord-269992-ruf0vvz4 65 11 contamination contamination NN cord-269992-ruf0vvz4 65 12 and and CC cord-269992-ruf0vvz4 65 13 disease disease NN cord-269992-ruf0vvz4 65 14 spread spread VBD cord-269992-ruf0vvz4 65 15 . . . cord-269992-ruf0vvz4 66 1 ( ( -LRB- cord-269992-ruf0vvz4 66 2 10 10 CD cord-269992-ruf0vvz4 66 3 ) ) -RRB- cord-269992-ruf0vvz4 67 1 There there EX cord-269992-ruf0vvz4 67 2 is be VBZ cord-269992-ruf0vvz4 67 3 the the DT cord-269992-ruf0vvz4 67 4 possibility possibility NN cord-269992-ruf0vvz4 67 5 of of IN cord-269992-ruf0vvz4 67 6 enhanced enhanced JJ cord-269992-ruf0vvz4 67 7 compliance compliance NN cord-269992-ruf0vvz4 67 8 , , , cord-269992-ruf0vvz4 67 9 especially especially RB cord-269992-ruf0vvz4 67 10 in in IN cord-269992-ruf0vvz4 67 11 children child NNS cord-269992-ruf0vvz4 67 12 [ [ -LRB- cord-269992-ruf0vvz4 67 13 5 5 CD cord-269992-ruf0vvz4 67 14 ] ] -RRB- cord-269992-ruf0vvz4 67 15 . . . cord-269992-ruf0vvz4 68 1 Edible edible JJ cord-269992-ruf0vvz4 68 2 vaccines vaccine NNS cord-269992-ruf0vvz4 68 3 have have VBP cord-269992-ruf0vvz4 68 4 received receive VBN cord-269992-ruf0vvz4 68 5 considerable considerable JJ cord-269992-ruf0vvz4 68 6 attention attention NN cord-269992-ruf0vvz4 68 7 from from IN cord-269992-ruf0vvz4 68 8 researchers researcher NNS cord-269992-ruf0vvz4 68 9 in in IN cord-269992-ruf0vvz4 68 10 both both DT cord-269992-ruf0vvz4 68 11 academia academia NN cord-269992-ruf0vvz4 68 12 and and CC cord-269992-ruf0vvz4 68 13 industry industry NN cord-269992-ruf0vvz4 68 14 . . . cord-269992-ruf0vvz4 69 1 The the DT cord-269992-ruf0vvz4 69 2 first first JJ cord-269992-ruf0vvz4 69 3 plant plant NN cord-269992-ruf0vvz4 69 4 - - HYPH cord-269992-ruf0vvz4 69 5 derived derive VBN cord-269992-ruf0vvz4 69 6 rabies rabie NNS cord-269992-ruf0vvz4 69 7 vaccine vaccine NN cord-269992-ruf0vvz4 69 8 was be VBD cord-269992-ruf0vvz4 69 9 produced produce VBN cord-269992-ruf0vvz4 69 10 in in IN cord-269992-ruf0vvz4 69 11 tomatoes tomato NNS cord-269992-ruf0vvz4 69 12 and and CC cord-269992-ruf0vvz4 69 13 offered offer VBD cord-269992-ruf0vvz4 69 14 the the DT cord-269992-ruf0vvz4 69 15 advantages advantage NNS cord-269992-ruf0vvz4 69 16 of of IN cord-269992-ruf0vvz4 69 17 high high JJ cord-269992-ruf0vvz4 69 18 biomass biomass NN cord-269992-ruf0vvz4 69 19 yields yield NNS cord-269992-ruf0vvz4 69 20 and and CC cord-269992-ruf0vvz4 69 21 the the DT cord-269992-ruf0vvz4 69 22 increased increase VBN cord-269992-ruf0vvz4 69 23 containment containment NN cord-269992-ruf0vvz4 69 24 by by IN cord-269992-ruf0vvz4 69 25 growth growth NN cord-269992-ruf0vvz4 69 26 in in IN cord-269992-ruf0vvz4 69 27 greenhouses greenhouse NNS cord-269992-ruf0vvz4 69 28 . . . cord-269992-ruf0vvz4 70 1 Lettuce lettuce NN cord-269992-ruf0vvz4 70 2 and and CC cord-269992-ruf0vvz4 70 3 bananas banana NNS cord-269992-ruf0vvz4 70 4 have have VBP cord-269992-ruf0vvz4 70 5 also also RB cord-269992-ruf0vvz4 70 6 been be VBN cord-269992-ruf0vvz4 70 7 utilized utilize VBN cord-269992-ruf0vvz4 70 8 for for IN cord-269992-ruf0vvz4 70 9 the the DT cord-269992-ruf0vvz4 70 10 production production NN cord-269992-ruf0vvz4 70 11 of of IN cord-269992-ruf0vvz4 70 12 plant plant NN cord-269992-ruf0vvz4 70 13 - - HYPH cord-269992-ruf0vvz4 70 14 based base VBN cord-269992-ruf0vvz4 70 15 vaccines vaccine NNS cord-269992-ruf0vvz4 70 16 [ [ -LRB- cord-269992-ruf0vvz4 70 17 8 8 CD cord-269992-ruf0vvz4 70 18 ] ] -RRB- cord-269992-ruf0vvz4 70 19 [ [ -LRB- cord-269992-ruf0vvz4 70 20 9 9 CD cord-269992-ruf0vvz4 70 21 ] ] -RRB- cord-269992-ruf0vvz4 70 22 [ [ -LRB- cord-269992-ruf0vvz4 70 23 10 10 CD cord-269992-ruf0vvz4 70 24 ] ] -RRB- cord-269992-ruf0vvz4 70 25 . . . cord-269992-ruf0vvz4 71 1 The the DT cord-269992-ruf0vvz4 71 2 edible edible JJ cord-269992-ruf0vvz4 71 3 can can MD cord-269992-ruf0vvz4 71 4 be be VB cord-269992-ruf0vvz4 71 5 developed develop VBN cord-269992-ruf0vvz4 71 6 in in IN cord-269992-ruf0vvz4 71 7 many many JJ cord-269992-ruf0vvz4 71 8 desired desire VBN cord-269992-ruf0vvz4 71 9 plants plant NNS cord-269992-ruf0vvz4 71 10 . . . cord-269992-ruf0vvz4 72 1 Recently recently RB cord-269992-ruf0vvz4 72 2 , , , cord-269992-ruf0vvz4 72 3 there there EX cord-269992-ruf0vvz4 72 4 are be VBP cord-269992-ruf0vvz4 72 5 different different JJ cord-269992-ruf0vvz4 72 6 crops crop NNS cord-269992-ruf0vvz4 72 7 like like IN cord-269992-ruf0vvz4 72 8 tomato tomato NN cord-269992-ruf0vvz4 72 9 , , , cord-269992-ruf0vvz4 72 10 carrot carrot NN cord-269992-ruf0vvz4 72 11 , , , cord-269992-ruf0vvz4 72 12 corn corn NN cord-269992-ruf0vvz4 72 13 , , , cord-269992-ruf0vvz4 72 14 cucumber cucumber NN cord-269992-ruf0vvz4 72 15 , , , cord-269992-ruf0vvz4 72 16 lettuce lettuce NN cord-269992-ruf0vvz4 72 17 , , , cord-269992-ruf0vvz4 72 18 and and CC cord-269992-ruf0vvz4 72 19 spinach spinach NN cord-269992-ruf0vvz4 72 20 plants plant NNS cord-269992-ruf0vvz4 72 21 that that WDT cord-269992-ruf0vvz4 72 22 have have VBP cord-269992-ruf0vvz4 72 23 been be VBN cord-269992-ruf0vvz4 72 24 utilized utilize VBN cord-269992-ruf0vvz4 72 25 as as IN cord-269992-ruf0vvz4 72 26 a a DT cord-269992-ruf0vvz4 72 27 green green JJ cord-269992-ruf0vvz4 72 28 factory factory NN cord-269992-ruf0vvz4 72 29 to to TO cord-269992-ruf0vvz4 72 30 express express VB cord-269992-ruf0vvz4 72 31 , , , cord-269992-ruf0vvz4 72 32 and and CC cord-269992-ruf0vvz4 72 33 purify purify VB cord-269992-ruf0vvz4 72 34 the the DT cord-269992-ruf0vvz4 72 35 desired desire VBN cord-269992-ruf0vvz4 72 36 protein protein NN cord-269992-ruf0vvz4 72 37 , , , cord-269992-ruf0vvz4 72 38 enzymes enzyme NNS cord-269992-ruf0vvz4 72 39 , , , cord-269992-ruf0vvz4 72 40 antigens antigen NNS cord-269992-ruf0vvz4 72 41 , , , cord-269992-ruf0vvz4 72 42 and and CC cord-269992-ruf0vvz4 72 43 biopharmaceuticals biopharmaceutical NNS cord-269992-ruf0vvz4 72 44 compounds compound NNS cord-269992-ruf0vvz4 72 45 [ [ -LRB- cord-269992-ruf0vvz4 72 46 3 3 CD cord-269992-ruf0vvz4 72 47 ] ] -RRB- cord-269992-ruf0vvz4 72 48 [ [ -LRB- cord-269992-ruf0vvz4 72 49 4 4 CD cord-269992-ruf0vvz4 72 50 ] ] -RRB- cord-269992-ruf0vvz4 72 51 [ [ -LRB- cord-269992-ruf0vvz4 72 52 5 5 CD cord-269992-ruf0vvz4 72 53 ] ] -RRB- cord-269992-ruf0vvz4 72 54 [ [ -LRB- cord-269992-ruf0vvz4 72 55 6 6 CD cord-269992-ruf0vvz4 72 56 ] ] -RRB- cord-269992-ruf0vvz4 72 57 [ [ -LRB- cord-269992-ruf0vvz4 72 58 7 7 CD cord-269992-ruf0vvz4 72 59 ] ] -RRB- cord-269992-ruf0vvz4 72 60 [ [ -LRB- cord-269992-ruf0vvz4 72 61 8 8 CD cord-269992-ruf0vvz4 72 62 ] ] -RRB- cord-269992-ruf0vvz4 72 63 [ [ -LRB- cord-269992-ruf0vvz4 72 64 9 9 CD cord-269992-ruf0vvz4 72 65 ] ] -RRB- cord-269992-ruf0vvz4 72 66 [ [ -LRB- cord-269992-ruf0vvz4 72 67 10 10 CD cord-269992-ruf0vvz4 72 68 ] ] -RRB- cord-269992-ruf0vvz4 72 69 [ [ -LRB- cord-269992-ruf0vvz4 72 70 11 11 CD cord-269992-ruf0vvz4 72 71 ] ] -RRB- cord-269992-ruf0vvz4 72 72 [ [ -LRB- cord-269992-ruf0vvz4 72 73 12 12 CD cord-269992-ruf0vvz4 72 74 ] ] -RRB- cord-269992-ruf0vvz4 72 75 . . . cord-269992-ruf0vvz4 73 1 The the DT cord-269992-ruf0vvz4 73 2 most most RBS cord-269992-ruf0vvz4 73 3 important important JJ cord-269992-ruf0vvz4 73 4 advantage advantage NN cord-269992-ruf0vvz4 73 5 of of IN cord-269992-ruf0vvz4 73 6 plant plant NN cord-269992-ruf0vvz4 73 7 expression expression NN cord-269992-ruf0vvz4 73 8 systems system NNS cord-269992-ruf0vvz4 73 9 is be VBZ cord-269992-ruf0vvz4 73 10 the the DT cord-269992-ruf0vvz4 73 11 low low JJ cord-269992-ruf0vvz4 73 12 cost cost NN cord-269992-ruf0vvz4 73 13 . . . cord-269992-ruf0vvz4 74 1 Tomato tomato NN cord-269992-ruf0vvz4 74 2 can can MD cord-269992-ruf0vvz4 74 3 be be VB cord-269992-ruf0vvz4 74 4 used use VBN cord-269992-ruf0vvz4 74 5 as as IN cord-269992-ruf0vvz4 74 6 for for IN cord-269992-ruf0vvz4 74 7 vaccine vaccine NN cord-269992-ruf0vvz4 74 8 production production NN cord-269992-ruf0vvz4 74 9 and and CC cord-269992-ruf0vvz4 74 10 the the DT cord-269992-ruf0vvz4 74 11 used use VBN cord-269992-ruf0vvz4 74 12 as as IN cord-269992-ruf0vvz4 74 13 salad salad NN cord-269992-ruf0vvz4 74 14 which which WDT cord-269992-ruf0vvz4 74 15 facilitates facilitate VBZ cord-269992-ruf0vvz4 74 16 the the DT cord-269992-ruf0vvz4 74 17 easy easy JJ cord-269992-ruf0vvz4 74 18 oral oral JJ cord-269992-ruf0vvz4 74 19 delivery delivery NN cord-269992-ruf0vvz4 74 20 of of IN cord-269992-ruf0vvz4 74 21 a a DT cord-269992-ruf0vvz4 74 22 particular particular JJ cord-269992-ruf0vvz4 74 23 vaccine vaccine NN cord-269992-ruf0vvz4 74 24 . . . cord-269992-ruf0vvz4 75 1 As as IN cord-269992-ruf0vvz4 75 2 an an DT cord-269992-ruf0vvz4 75 3 example example NN cord-269992-ruf0vvz4 75 4 , , , cord-269992-ruf0vvz4 75 5 tomato tomato NN cord-269992-ruf0vvz4 75 6 has have VBZ cord-269992-ruf0vvz4 75 7 excellent excellent JJ cord-269992-ruf0vvz4 75 8 biomass biomass NN cord-269992-ruf0vvz4 75 9 and and CC cord-269992-ruf0vvz4 75 10 easily easily RB cord-269992-ruf0vvz4 75 11 transformed transform VBN cord-269992-ruf0vvz4 75 12 and and CC cord-269992-ruf0vvz4 75 13 generate generate VB cord-269992-ruf0vvz4 75 14 the the DT cord-269992-ruf0vvz4 75 15 whole whole JJ cord-269992-ruf0vvz4 75 16 plant plant NN cord-269992-ruf0vvz4 75 17 within within IN cord-269992-ruf0vvz4 75 18 short short JJ cord-269992-ruf0vvz4 75 19 period period NN cord-269992-ruf0vvz4 75 20 and and CC cord-269992-ruf0vvz4 75 21 this this DT cord-269992-ruf0vvz4 75 22 provides provide VBZ cord-269992-ruf0vvz4 75 23 an an DT cord-269992-ruf0vvz4 75 24 ideal ideal JJ cord-269992-ruf0vvz4 75 25 choice choice NN cord-269992-ruf0vvz4 75 26 for for IN cord-269992-ruf0vvz4 75 27 vaccine vaccine NN cord-269992-ruf0vvz4 75 28 production production NN cord-269992-ruf0vvz4 75 29 . . . cord-269992-ruf0vvz4 76 1 Therefore therefore RB cord-269992-ruf0vvz4 76 2 , , , cord-269992-ruf0vvz4 76 3 tomato tomato NN cord-269992-ruf0vvz4 76 4 is be VBZ cord-269992-ruf0vvz4 76 5 no no DT cord-269992-ruf0vvz4 76 6 doubt doubt RB cord-269992-ruf0vvz4 76 7 a a DT cord-269992-ruf0vvz4 76 8 green green JJ cord-269992-ruf0vvz4 76 9 vaccine vaccine NN cord-269992-ruf0vvz4 76 10 factory factory NN cord-269992-ruf0vvz4 76 11 . . . cord-269992-ruf0vvz4 77 1 Currently currently RB cord-269992-ruf0vvz4 77 2 , , , cord-269992-ruf0vvz4 77 3 there there EX cord-269992-ruf0vvz4 77 4 is be VBZ cord-269992-ruf0vvz4 77 5 no no DT cord-269992-ruf0vvz4 77 6 approved approve VBN cord-269992-ruf0vvz4 77 7 vaccine vaccine NN cord-269992-ruf0vvz4 77 8 or or CC cord-269992-ruf0vvz4 77 9 treatment treatment NN cord-269992-ruf0vvz4 77 10 with with IN cord-269992-ruf0vvz4 77 11 proven prove VBN cord-269992-ruf0vvz4 77 12 efficacy efficacy NN cord-269992-ruf0vvz4 77 13 against against IN cord-269992-ruf0vvz4 77 14 newly newly RB cord-269992-ruf0vvz4 77 15 emerged emerge VBN cord-269992-ruf0vvz4 77 16 CoV CoV NNP cord-269992-ruf0vvz4 77 17 COVID-19 COVID-19 NNP cord-269992-ruf0vvz4 77 18 . . . cord-269992-ruf0vvz4 78 1 While while IN cord-269992-ruf0vvz4 78 2 previous previous JJ cord-269992-ruf0vvz4 78 3 work work NN cord-269992-ruf0vvz4 78 4 on on IN cord-269992-ruf0vvz4 78 5 SARS SARS NNP cord-269992-ruf0vvz4 78 6 - - HYPH cord-269992-ruf0vvz4 78 7 CoV CoV NNP cord-269992-ruf0vvz4 78 8 vaccines vaccine NNS cord-269992-ruf0vvz4 78 9 have have VBP cord-269992-ruf0vvz4 78 10 shown show VBN cord-269992-ruf0vvz4 78 11 that that IN cord-269992-ruf0vvz4 78 12 the the DT cord-269992-ruf0vvz4 78 13 Spike Spike NNP cord-269992-ruf0vvz4 78 14 glycoprotein glycoprotein NN cord-269992-ruf0vvz4 78 15 ( ( -LRB- cord-269992-ruf0vvz4 78 16 S s NN cord-269992-ruf0vvz4 78 17 ) ) -RRB- cord-269992-ruf0vvz4 78 18 is be VBZ cord-269992-ruf0vvz4 78 19 the the DT cord-269992-ruf0vvz4 78 20 main main JJ cord-269992-ruf0vvz4 78 21 inducer inducer NN cord-269992-ruf0vvz4 78 22 of of IN cord-269992-ruf0vvz4 78 23 neutralizing neutralize VBG cord-269992-ruf0vvz4 78 24 antibodies antibody NNS cord-269992-ruf0vvz4 78 25 . . . cord-269992-ruf0vvz4 79 1 The the DT cord-269992-ruf0vvz4 79 2 CoVs CoVs NNP cord-269992-ruf0vvz4 79 3 infection infection NN cord-269992-ruf0vvz4 79 4 causes cause VBZ cord-269992-ruf0vvz4 79 5 severe severe JJ cord-269992-ruf0vvz4 79 6 respiratory respiratory JJ cord-269992-ruf0vvz4 79 7 disease disease NN cord-269992-ruf0vvz4 79 8 with with IN cord-269992-ruf0vvz4 79 9 clinical clinical JJ cord-269992-ruf0vvz4 79 10 symptoms symptom NNS cord-269992-ruf0vvz4 79 11 ; ; : cord-269992-ruf0vvz4 79 12 specifically specifically RB cord-269992-ruf0vvz4 79 13 , , , cord-269992-ruf0vvz4 79 14 patients patient NNS cord-269992-ruf0vvz4 79 15 develop develop VBP cord-269992-ruf0vvz4 79 16 acute acute JJ cord-269992-ruf0vvz4 79 17 respiratory respiratory JJ cord-269992-ruf0vvz4 79 18 symptoms symptom NNS cord-269992-ruf0vvz4 79 19 . . . cord-269992-ruf0vvz4 80 1 The the DT cord-269992-ruf0vvz4 80 2 Spike Spike NNP cord-269992-ruf0vvz4 80 3 protein protein NN cord-269992-ruf0vvz4 80 4 can can MD cord-269992-ruf0vvz4 80 5 be be VB cord-269992-ruf0vvz4 80 6 used use VBN cord-269992-ruf0vvz4 80 7 to to TO cord-269992-ruf0vvz4 80 8 develop develop VB cord-269992-ruf0vvz4 80 9 a a DT cord-269992-ruf0vvz4 80 10 vaccine vaccine NN cord-269992-ruf0vvz4 80 11 against against IN cord-269992-ruf0vvz4 80 12 the the DT cord-269992-ruf0vvz4 80 13 COVID-19 COVID-19 NNP cord-269992-ruf0vvz4 80 14 . . . cord-269992-ruf0vvz4 81 1 The the DT cord-269992-ruf0vvz4 81 2 Spike spike NN cord-269992-ruf0vvz4 81 3 ( ( -LRB- cord-269992-ruf0vvz4 81 4 S S NNP cord-269992-ruf0vvz4 81 5 ) ) -RRB- cord-269992-ruf0vvz4 81 6 protein protein NN cord-269992-ruf0vvz4 81 7 gene gene NN cord-269992-ruf0vvz4 81 8 or or CC cord-269992-ruf0vvz4 81 9 subunit subunit NN cord-269992-ruf0vvz4 81 10 of of IN cord-269992-ruf0vvz4 81 11 Spike Spike NNP cord-269992-ruf0vvz4 81 12 like like IN cord-269992-ruf0vvz4 81 13 S1 s1 NN cord-269992-ruf0vvz4 81 14 subunit subunit NN cord-269992-ruf0vvz4 81 15 can can MD cord-269992-ruf0vvz4 81 16 be be VB cord-269992-ruf0vvz4 81 17 cloned clone VBN cord-269992-ruf0vvz4 81 18 into into IN cord-269992-ruf0vvz4 81 19 a a DT cord-269992-ruf0vvz4 81 20 plant plant NN cord-269992-ruf0vvz4 81 21 expression expression NN cord-269992-ruf0vvz4 81 22 vector vector NN cord-269992-ruf0vvz4 81 23 and and CC cord-269992-ruf0vvz4 81 24 the the DT cord-269992-ruf0vvz4 81 25 desired desire VBN cord-269992-ruf0vvz4 81 26 plant plant NN cord-269992-ruf0vvz4 81 27 like like IN cord-269992-ruf0vvz4 81 28 tomato tomato NN cord-269992-ruf0vvz4 81 29 , , , cord-269992-ruf0vvz4 81 30 cu cu NN cord-269992-ruf0vvz4 81 31 - - NN cord-269992-ruf0vvz4 81 32 cumber cumber NN cord-269992-ruf0vvz4 81 33 , , , cord-269992-ruf0vvz4 81 34 or or CC cord-269992-ruf0vvz4 81 35 lettuce lettuce NN cord-269992-ruf0vvz4 81 36 can can MD cord-269992-ruf0vvz4 81 37 be be VB cord-269992-ruf0vvz4 81 38 transformed transform VBN cord-269992-ruf0vvz4 81 39 . . . cord-269992-ruf0vvz4 82 1 The the DT cord-269992-ruf0vvz4 82 2 developed developed JJ cord-269992-ruf0vvz4 82 3 transgenic transgenic JJ cord-269992-ruf0vvz4 82 4 plants plant NNS cord-269992-ruf0vvz4 82 5 can can MD cord-269992-ruf0vvz4 82 6 be be VB cord-269992-ruf0vvz4 82 7 used use VBN cord-269992-ruf0vvz4 82 8 as as IN cord-269992-ruf0vvz4 82 9 salad salad NN cord-269992-ruf0vvz4 82 10 and and CC cord-269992-ruf0vvz4 82 11 easily easily RB cord-269992-ruf0vvz4 82 12 delivered deliver VBN cord-269992-ruf0vvz4 82 13 orally orally RB cord-269992-ruf0vvz4 82 14 and and CC cord-269992-ruf0vvz4 82 15 immunized immunize VBD cord-269992-ruf0vvz4 82 16 the the DT cord-269992-ruf0vvz4 82 17 human human NN cord-269992-ruf0vvz4 82 18 against against IN cord-269992-ruf0vvz4 82 19 the the DT cord-269992-ruf0vvz4 82 20 newly newly RB cord-269992-ruf0vvz4 82 21 emerged emerge VBN cord-269992-ruf0vvz4 82 22 virus virus NN cord-269992-ruf0vvz4 82 23 . . . cord-269992-ruf0vvz4 83 1 Several several JJ cord-269992-ruf0vvz4 83 2 teams team NNS cord-269992-ruf0vvz4 83 3 are be VBP cord-269992-ruf0vvz4 83 4 working work VBG cord-269992-ruf0vvz4 83 5 on on IN cord-269992-ruf0vvz4 83 6 a a DT cord-269992-ruf0vvz4 83 7 vaccine vaccine NN cord-269992-ruf0vvz4 83 8 to to TO cord-269992-ruf0vvz4 83 9 protect protect VB cord-269992-ruf0vvz4 83 10 against against IN cord-269992-ruf0vvz4 83 11 the the DT cord-269992-ruf0vvz4 83 12 new new JJ cord-269992-ruf0vvz4 83 13 CoV. CoV. NNP cord-269992-ruf0vvz4 84 1 Recently recently RB cord-269992-ruf0vvz4 84 2 , , , cord-269992-ruf0vvz4 84 3 the the DT cord-269992-ruf0vvz4 84 4 therapeutic therapeutic JJ cord-269992-ruf0vvz4 84 5 options option NNS cord-269992-ruf0vvz4 84 6 for for IN cord-269992-ruf0vvz4 84 7 COVID-19 COVID-19 NNP cord-269992-ruf0vvz4 84 8 has have VBZ cord-269992-ruf0vvz4 84 9 been be VBN cord-269992-ruf0vvz4 84 10 discussed discuss VBN cord-269992-ruf0vvz4 84 11 and and CC cord-269992-ruf0vvz4 84 12 suggested suggest VBN cord-269992-ruf0vvz4 84 13 in in IN cord-269992-ruf0vvz4 84 14 a a DT cord-269992-ruf0vvz4 84 15 published publish VBN cord-269992-ruf0vvz4 84 16 paper paper NN cord-269992-ruf0vvz4 84 17 [ [ -LRB- cord-269992-ruf0vvz4 84 18 15 15 CD cord-269992-ruf0vvz4 84 19 ] ] -RRB- cord-269992-ruf0vvz4 84 20 . . . cord-269992-ruf0vvz4 85 1 However however RB cord-269992-ruf0vvz4 85 2 , , , cord-269992-ruf0vvz4 85 3 the the DT cord-269992-ruf0vvz4 85 4 development development NN cord-269992-ruf0vvz4 85 5 of of IN cord-269992-ruf0vvz4 85 6 a a DT cord-269992-ruf0vvz4 85 7 protective protective JJ cord-269992-ruf0vvz4 85 8 vaccine vaccine NN cord-269992-ruf0vvz4 85 9 is be VBZ cord-269992-ruf0vvz4 85 10 of of IN cord-269992-ruf0vvz4 85 11 great great JJ cord-269992-ruf0vvz4 85 12 importance importance NN cord-269992-ruf0vvz4 85 13 to to TO cord-269992-ruf0vvz4 85 14 prevent prevent VB cord-269992-ruf0vvz4 85 15 and and CC cord-269992-ruf0vvz4 85 16 control control VB cord-269992-ruf0vvz4 85 17 the the DT cord-269992-ruf0vvz4 85 18 spread spread NN cord-269992-ruf0vvz4 85 19 of of IN cord-269992-ruf0vvz4 85 20 the the DT cord-269992-ruf0vvz4 85 21 virus virus NN cord-269992-ruf0vvz4 85 22 as as RB cord-269992-ruf0vvz4 85 23 well well RB cord-269992-ruf0vvz4 85 24 as as IN cord-269992-ruf0vvz4 85 25 any any DT cord-269992-ruf0vvz4 85 26 future future JJ cord-269992-ruf0vvz4 85 27 outbreaks outbreak NNS cord-269992-ruf0vvz4 85 28 . . . cord-269992-ruf0vvz4 86 1 The the DT cord-269992-ruf0vvz4 86 2 newly newly RB cord-269992-ruf0vvz4 86 3 emerged emerge VBN cord-269992-ruf0vvz4 86 4 CoV cov NN cord-269992-ruf0vvz4 86 5 has have VBZ cord-269992-ruf0vvz4 86 6 now now RB cord-269992-ruf0vvz4 86 7 become become VBN cord-269992-ruf0vvz4 86 8 a a DT cord-269992-ruf0vvz4 86 9 global global JJ cord-269992-ruf0vvz4 86 10 threat threat NN cord-269992-ruf0vvz4 86 11 to to IN cord-269992-ruf0vvz4 86 12 human human JJ cord-269992-ruf0vvz4 86 13 health health NN cord-269992-ruf0vvz4 86 14 . . . cord-269992-ruf0vvz4 87 1 As as IN cord-269992-ruf0vvz4 87 2 on on IN cord-269992-ruf0vvz4 87 3 February February NNP cord-269992-ruf0vvz4 87 4 23 23 CD cord-269992-ruf0vvz4 87 5 , , , cord-269992-ruf0vvz4 87 6 2020 2020 CD cord-269992-ruf0vvz4 87 7 , , , cord-269992-ruf0vvz4 87 8 this this DT cord-269992-ruf0vvz4 87 9 virus virus NN cord-269992-ruf0vvz4 87 10 has have VBZ cord-269992-ruf0vvz4 87 11 been be VBN cord-269992-ruf0vvz4 87 12 spread spread VBN cord-269992-ruf0vvz4 87 13 to to IN cord-269992-ruf0vvz4 87 14 more more JJR cord-269992-ruf0vvz4 87 15 than than IN cord-269992-ruf0vvz4 87 16 34 34 CD cord-269992-ruf0vvz4 87 17 countries country NNS cord-269992-ruf0vvz4 87 18 including include VBG cord-269992-ruf0vvz4 87 19 China China NNP cord-269992-ruf0vvz4 87 20 with with IN cord-269992-ruf0vvz4 87 21 2,445 2,445 CD cord-269992-ruf0vvz4 87 22 deaths death NNS cord-269992-ruf0vvz4 87 23 and and CC cord-269992-ruf0vvz4 87 24 78,811 78,811 CD cord-269992-ruf0vvz4 87 25 confirmed confirm VBN cord-269992-ruf0vvz4 87 26 cases case NNS cord-269992-ruf0vvz4 87 27 [ [ -LRB- cord-269992-ruf0vvz4 87 28 1 1 CD cord-269992-ruf0vvz4 87 29 , , , cord-269992-ruf0vvz4 87 30 2 2 CD cord-269992-ruf0vvz4 87 31 ] ] -RRB- cord-269992-ruf0vvz4 87 32 . . . cord-269992-ruf0vvz4 88 1 The the DT cord-269992-ruf0vvz4 88 2 fast fast JJ cord-269992-ruf0vvz4 88 3 spread spread NN cord-269992-ruf0vvz4 88 4 of of IN cord-269992-ruf0vvz4 88 5 this this DT cord-269992-ruf0vvz4 88 6 virus virus NN cord-269992-ruf0vvz4 88 7 has have VBZ cord-269992-ruf0vvz4 88 8 attracted attract VBN cord-269992-ruf0vvz4 88 9 the the DT cord-269992-ruf0vvz4 88 10 researchers researcher NNS cord-269992-ruf0vvz4 88 11 towards towards IN cord-269992-ruf0vvz4 88 12 the the DT cord-269992-ruf0vvz4 88 13 development development NN cord-269992-ruf0vvz4 88 14 of of IN cord-269992-ruf0vvz4 88 15 an an DT cord-269992-ruf0vvz4 88 16 urgent urgent JJ cord-269992-ruf0vvz4 88 17 vaccine vaccine NN cord-269992-ruf0vvz4 88 18 to to TO cord-269992-ruf0vvz4 88 19 control control VB cord-269992-ruf0vvz4 88 20 the the DT cord-269992-ruf0vvz4 88 21 virus virus NN cord-269992-ruf0vvz4 88 22 infection infection NN cord-269992-ruf0vvz4 88 23 and and CC cord-269992-ruf0vvz4 88 24 disease disease NN cord-269992-ruf0vvz4 88 25 spread spread VBD cord-269992-ruf0vvz4 88 26 . . . cord-269992-ruf0vvz4 89 1 The the DT cord-269992-ruf0vvz4 89 2 full full JJ cord-269992-ruf0vvz4 89 3 - - HYPH cord-269992-ruf0vvz4 89 4 genome genome NN cord-269992-ruf0vvz4 89 5 of of IN cord-269992-ruf0vvz4 89 6 COVID-19 COVID-19 NNP cord-269992-ruf0vvz4 89 7 has have VBZ cord-269992-ruf0vvz4 89 8 provided provide VBN cord-269992-ruf0vvz4 89 9 the the DT cord-269992-ruf0vvz4 89 10 valuable valuable JJ cord-269992-ruf0vvz4 89 11 information information NN cord-269992-ruf0vvz4 89 12 which which WDT cord-269992-ruf0vvz4 89 13 can can MD cord-269992-ruf0vvz4 89 14 be be VB cord-269992-ruf0vvz4 89 15 used use VBN cord-269992-ruf0vvz4 89 16 to to TO cord-269992-ruf0vvz4 89 17 design design VB cord-269992-ruf0vvz4 89 18 and and CC cord-269992-ruf0vvz4 89 19 develop develop VB cord-269992-ruf0vvz4 89 20 an an DT cord-269992-ruf0vvz4 89 21 effective effective JJ cord-269992-ruf0vvz4 89 22 vaccine vaccine NN cord-269992-ruf0vvz4 89 23 [ [ -LRB- cord-269992-ruf0vvz4 89 24 16 16 CD cord-269992-ruf0vvz4 89 25 ] ] -RRB- cord-269992-ruf0vvz4 89 26 . . . cord-269992-ruf0vvz4 90 1 The the DT cord-269992-ruf0vvz4 90 2 plant plant NN cord-269992-ruf0vvz4 90 3 - - HYPH cord-269992-ruf0vvz4 90 4 based base VBN cord-269992-ruf0vvz4 90 5 edible edible JJ cord-269992-ruf0vvz4 90 6 vaccine vaccine NN cord-269992-ruf0vvz4 90 7 has have VBZ cord-269992-ruf0vvz4 90 8 now now RB cord-269992-ruf0vvz4 90 9 attracted attract VBN cord-269992-ruf0vvz4 90 10 many many JJ cord-269992-ruf0vvz4 90 11 researchers researcher NNS cord-269992-ruf0vvz4 90 12 and and CC cord-269992-ruf0vvz4 90 13 pharmaceutical pharmaceutical NN cord-269992-ruf0vvz4 90 14 companies company NNS cord-269992-ruf0vvz4 90 15 to to TO cord-269992-ruf0vvz4 90 16 develop develop VB cord-269992-ruf0vvz4 90 17 fast fast JJ cord-269992-ruf0vvz4 90 18 and and CC cord-269992-ruf0vvz4 90 19 cheaper cheap JJR cord-269992-ruf0vvz4 90 20 vaccines vaccine NNS cord-269992-ruf0vvz4 90 21 against against IN cord-269992-ruf0vvz4 90 22 many many JJ cord-269992-ruf0vvz4 90 23 pathogens pathogen NNS cord-269992-ruf0vvz4 90 24 . . . cord-269992-ruf0vvz4 91 1 This this DT cord-269992-ruf0vvz4 91 2 technology technology NN cord-269992-ruf0vvz4 91 3 has have VBZ cord-269992-ruf0vvz4 91 4 got get VBN cord-269992-ruf0vvz4 91 5 more more JJR cord-269992-ruf0vvz4 91 6 publicity publicity NN cord-269992-ruf0vvz4 91 7 in in IN cord-269992-ruf0vvz4 91 8 the the DT cord-269992-ruf0vvz4 91 9 last last JJ cord-269992-ruf0vvz4 91 10 10 10 CD cord-269992-ruf0vvz4 91 11 years year NNS cord-269992-ruf0vvz4 91 12 and and CC cord-269992-ruf0vvz4 91 13 have have VBP cord-269992-ruf0vvz4 91 14 proven prove VBN cord-269992-ruf0vvz4 91 15 the the DT cord-269992-ruf0vvz4 91 16 efficiency efficiency NN cord-269992-ruf0vvz4 91 17 to to TO cord-269992-ruf0vvz4 91 18 express express VB cord-269992-ruf0vvz4 91 19 the the DT cord-269992-ruf0vvz4 91 20 desired desire VBN cord-269992-ruf0vvz4 91 21 protein protein NN cord-269992-ruf0vvz4 91 22 either either CC cord-269992-ruf0vvz4 91 23 as as IN cord-269992-ruf0vvz4 91 24 antigens antigen NNS cord-269992-ruf0vvz4 91 25 or or CC cord-269992-ruf0vvz4 91 26 pharmaceuticals pharmaceutical NNS cord-269992-ruf0vvz4 91 27 therapeutic therapeutic JJ cord-269992-ruf0vvz4 91 28 compounds compound NNS cord-269992-ruf0vvz4 91 29 in in IN cord-269992-ruf0vvz4 91 30 the the DT cord-269992-ruf0vvz4 91 31 desired desire VBN cord-269992-ruf0vvz4 91 32 plant plant NN cord-269992-ruf0vvz4 91 33 cells cell NNS cord-269992-ruf0vvz4 91 34 . . . cord-269992-ruf0vvz4 92 1 This this DT cord-269992-ruf0vvz4 92 2 novel novel NN cord-269992-ruf0vvz4 92 3 technology technology NN cord-269992-ruf0vvz4 92 4 provides provide VBZ cord-269992-ruf0vvz4 92 5 the the DT cord-269992-ruf0vvz4 92 6 high high JJ cord-269992-ruf0vvz4 92 7 and and CC cord-269992-ruf0vvz4 92 8 fast fast JJ cord-269992-ruf0vvz4 92 9 expression expression NN cord-269992-ruf0vvz4 92 10 , , , cord-269992-ruf0vvz4 92 11 purification purification NN cord-269992-ruf0vvz4 92 12 , , , cord-269992-ruf0vvz4 92 13 and and CC cord-269992-ruf0vvz4 92 14 better well JJR cord-269992-ruf0vvz4 92 15 stability stability NN cord-269992-ruf0vvz4 92 16 of of IN cord-269992-ruf0vvz4 92 17 desired desire VBN cord-269992-ruf0vvz4 92 18 proteins protein NNS cord-269992-ruf0vvz4 92 19 in in IN cord-269992-ruf0vvz4 92 20 to to IN cord-269992-ruf0vvz4 92 21 plant plant NN cord-269992-ruf0vvz4 92 22 cells cell NNS cord-269992-ruf0vvz4 92 23 as as RB cord-269992-ruf0vvz4 92 24 well well RB cord-269992-ruf0vvz4 92 25 as as IN cord-269992-ruf0vvz4 92 26 their -PRON- PRP$ cord-269992-ruf0vvz4 92 27 removal removal NN cord-269992-ruf0vvz4 92 28 of of IN cord-269992-ruf0vvz4 92 29 refrigeration refrigeration NN cord-269992-ruf0vvz4 92 30 requirement requirement NN cord-269992-ruf0vvz4 92 31 and and CC cord-269992-ruf0vvz4 92 32 trained train VBN cord-269992-ruf0vvz4 92 33 medical medical JJ cord-269992-ruf0vvz4 92 34 personnel personnel NNS cord-269992-ruf0vvz4 92 35 for for IN cord-269992-ruf0vvz4 92 36 delivery delivery NN cord-269992-ruf0vvz4 92 37 . . . cord-269992-ruf0vvz4 93 1 The the DT cord-269992-ruf0vvz4 93 2 edible edible JJ cord-269992-ruf0vvz4 93 3 vaccine vaccine NN cord-269992-ruf0vvz4 93 4 also also RB cord-269992-ruf0vvz4 93 5 removes remove VBZ cord-269992-ruf0vvz4 93 6 the the DT cord-269992-ruf0vvz4 93 7 risk risk NN cord-269992-ruf0vvz4 93 8 factors factor NNS cord-269992-ruf0vvz4 93 9 and and CC cord-269992-ruf0vvz4 93 10 safety safety NN cord-269992-ruf0vvz4 93 11 and and CC cord-269992-ruf0vvz4 93 12 regulatory regulatory JJ cord-269992-ruf0vvz4 93 13 issues issue NNS cord-269992-ruf0vvz4 93 14 related relate VBN cord-269992-ruf0vvz4 93 15 to to IN cord-269992-ruf0vvz4 93 16 living live VBG cord-269992-ruf0vvz4 93 17 organisms organism NNS cord-269992-ruf0vvz4 93 18 . . . cord-269992-ruf0vvz4 94 1 The the DT cord-269992-ruf0vvz4 94 2 edible edible JJ cord-269992-ruf0vvz4 94 3 vaccine vaccine NN cord-269992-ruf0vvz4 94 4 can can MD cord-269992-ruf0vvz4 94 5 be be VB cord-269992-ruf0vvz4 94 6 grown grow VBN cord-269992-ruf0vvz4 94 7 at at IN cord-269992-ruf0vvz4 94 8 the the DT cord-269992-ruf0vvz4 94 9 site site NN cord-269992-ruf0vvz4 94 10 of of IN cord-269992-ruf0vvz4 94 11 requirement requirement NN cord-269992-ruf0vvz4 94 12 and and CC cord-269992-ruf0vvz4 94 13 orally orally RB cord-269992-ruf0vvz4 94 14 delivered deliver VBN cord-269992-ruf0vvz4 94 15 in in IN cord-269992-ruf0vvz4 94 16 the the DT cord-269992-ruf0vvz4 94 17 form form NN cord-269992-ruf0vvz4 94 18 of of IN cord-269992-ruf0vvz4 94 19 salad salad NN cord-269992-ruf0vvz4 94 20 . . . cord-269992-ruf0vvz4 95 1 Therefore therefore RB cord-269992-ruf0vvz4 95 2 , , , cord-269992-ruf0vvz4 95 3 this this DT cord-269992-ruf0vvz4 95 4 technology technology NN cord-269992-ruf0vvz4 95 5 is be VBZ cord-269992-ruf0vvz4 95 6 emerging emerge VBG cord-269992-ruf0vvz4 95 7 as as IN cord-269992-ruf0vvz4 95 8 a a DT cord-269992-ruf0vvz4 95 9 novel novel JJ cord-269992-ruf0vvz4 95 10 and and CC cord-269992-ruf0vvz4 95 11 alternative alternative JJ cord-269992-ruf0vvz4 95 12 methods method NNS cord-269992-ruf0vvz4 95 13 for for IN cord-269992-ruf0vvz4 95 14 large large JJ cord-269992-ruf0vvz4 95 15 scale scale NN cord-269992-ruf0vvz4 95 16 edible edible JJ cord-269992-ruf0vvz4 95 17 vaccine vaccine NN cord-269992-ruf0vvz4 95 18 production production NN cord-269992-ruf0vvz4 95 19 , , , cord-269992-ruf0vvz4 95 20 manufacturing manufacturing NN cord-269992-ruf0vvz4 95 21 , , , cord-269992-ruf0vvz4 95 22 and and CC cord-269992-ruf0vvz4 95 23 processing processing NN cord-269992-ruf0vvz4 95 24 as as RB cord-269992-ruf0vvz4 95 25 well well RB cord-269992-ruf0vvz4 95 26 as as IN cord-269992-ruf0vvz4 95 27 commercialization commercialization NN cord-269992-ruf0vvz4 95 28 and and CC cord-269992-ruf0vvz4 95 29 easily easily RB cord-269992-ruf0vvz4 95 30 availability availability NN cord-269992-ruf0vvz4 95 31 to to IN cord-269992-ruf0vvz4 95 32 the the DT cord-269992-ruf0vvz4 95 33 needy needy JJ cord-269992-ruf0vvz4 95 34 persons person NNS cord-269992-ruf0vvz4 95 35 globally globally RB cord-269992-ruf0vvz4 95 36 . . . cord-269992-ruf0vvz4 96 1 This this DT cord-269992-ruf0vvz4 96 2 technology technology NN cord-269992-ruf0vvz4 96 3 will will MD cord-269992-ruf0vvz4 96 4 provide provide VB cord-269992-ruf0vvz4 96 5 an an DT cord-269992-ruf0vvz4 96 6 effective effective JJ cord-269992-ruf0vvz4 96 7 vaccination vaccination NN cord-269992-ruf0vvz4 96 8 against against IN cord-269992-ruf0vvz4 96 9 many many JJ cord-269992-ruf0vvz4 96 10 diseases disease NNS cord-269992-ruf0vvz4 96 11 in in IN cord-269992-ruf0vvz4 96 12 human human NN cord-269992-ruf0vvz4 96 13 and and CC cord-269992-ruf0vvz4 96 14 animal animal NN cord-269992-ruf0vvz4 96 15 globally globally RB cord-269992-ruf0vvz4 96 16 . . . cord-269992-ruf0vvz4 97 1 Based base VBN cord-269992-ruf0vvz4 97 2 on on IN cord-269992-ruf0vvz4 97 3 current current JJ cord-269992-ruf0vvz4 97 4 information information NN cord-269992-ruf0vvz4 97 5 , , , cord-269992-ruf0vvz4 97 6 it -PRON- PRP cord-269992-ruf0vvz4 97 7 is be VBZ cord-269992-ruf0vvz4 97 8 concluded conclude VBN cord-269992-ruf0vvz4 97 9 that that IN cord-269992-ruf0vvz4 97 10 there there EX cord-269992-ruf0vvz4 97 11 is be VBZ cord-269992-ruf0vvz4 97 12 an an DT cord-269992-ruf0vvz4 97 13 urgent urgent JJ cord-269992-ruf0vvz4 97 14 need need NN cord-269992-ruf0vvz4 97 15 to to TO cord-269992-ruf0vvz4 97 16 develop develop VB cord-269992-ruf0vvz4 97 17 a a DT cord-269992-ruf0vvz4 97 18 vaccine vaccine NN cord-269992-ruf0vvz4 97 19 against against IN cord-269992-ruf0vvz4 97 20 this this DT cord-269992-ruf0vvz4 97 21 fast fast JJ cord-269992-ruf0vvz4 97 22 spreading spread VBG cord-269992-ruf0vvz4 97 23 2019 2019 CD cord-269992-ruf0vvz4 97 24 novel novel NN cord-269992-ruf0vvz4 97 25 CoV cov NN cord-269992-ruf0vvz4 97 26 by by IN cord-269992-ruf0vvz4 97 27 using use VBG cord-269992-ruf0vvz4 97 28 various various JJ cord-269992-ruf0vvz4 97 29 vaccine vaccine NN cord-269992-ruf0vvz4 97 30 development development NN cord-269992-ruf0vvz4 97 31 technology technology NN cord-269992-ruf0vvz4 97 32 . . . cord-269992-ruf0vvz4 98 1 The the DT cord-269992-ruf0vvz4 98 2 edible edible JJ cord-269992-ruf0vvz4 98 3 vaccine vaccine NN cord-269992-ruf0vvz4 98 4 technology technology NN cord-269992-ruf0vvz4 98 5 will will MD cord-269992-ruf0vvz4 98 6 provide provide VB cord-269992-ruf0vvz4 98 7 a a DT cord-269992-ruf0vvz4 98 8 fast fast JJ cord-269992-ruf0vvz4 98 9 and and CC cord-269992-ruf0vvz4 98 10 cheaper cheap JJR cord-269992-ruf0vvz4 98 11 vaccine vaccine NN cord-269992-ruf0vvz4 98 12 not not RB cord-269992-ruf0vvz4 98 13 only only RB cord-269992-ruf0vvz4 98 14 this this DT cord-269992-ruf0vvz4 98 15 new new JJ cord-269992-ruf0vvz4 98 16 virus virus NN cord-269992-ruf0vvz4 98 17 but but CC cord-269992-ruf0vvz4 98 18 also also RB cord-269992-ruf0vvz4 98 19 against against IN cord-269992-ruf0vvz4 98 20 many many JJ cord-269992-ruf0vvz4 98 21 other other JJ cord-269992-ruf0vvz4 98 22 pathogens pathogen NNS cord-269992-ruf0vvz4 98 23 . . . cord-269992-ruf0vvz4 99 1 Disease Disease NNP cord-269992-ruf0vvz4 99 2 outbreak outbreak NN cord-269992-ruf0vvz4 99 3 news news NN cord-269992-ruf0vvz4 99 4 ( ( -LRB- cord-269992-ruf0vvz4 99 5 DONs DONs NNP cord-269992-ruf0vvz4 99 6 ) ) -RRB- cord-269992-ruf0vvz4 99 7 [ [ -LRB- cord-269992-ruf0vvz4 99 8 Internet internet NN cord-269992-ruf0vvz4 99 9 ] ] -RRB- cord-269992-ruf0vvz4 99 10 . . . cord-269992-ruf0vvz4 100 1 Geneva Geneva NNP cord-269992-ruf0vvz4 100 2 : : : cord-269992-ruf0vvz4 101 1 World World NNP cord-269992-ruf0vvz4 101 2 Health Health NNP cord-269992-ruf0vvz4 101 3 Organization Organization NNP cord-269992-ruf0vvz4 101 4 novel novel NN cord-269992-ruf0vvz4 101 5 coronavirus coronavirus NN cord-269992-ruf0vvz4 101 6 ( ( -LRB- cord-269992-ruf0vvz4 101 7 2019-nCoV 2019-ncov CD cord-269992-ruf0vvz4 101 8 ) ) -RRB- cord-269992-ruf0vvz4 101 9 situation situation NN cord-269992-ruf0vvz4 101 10 summary summary NN cord-269992-ruf0vvz4 102 1 Recent recent JJ cord-269992-ruf0vvz4 102 2 progress progress NN cord-269992-ruf0vvz4 102 3 in in IN cord-269992-ruf0vvz4 102 4 the the DT cord-269992-ruf0vvz4 102 5 development development NN cord-269992-ruf0vvz4 102 6 of of IN cord-269992-ruf0vvz4 102 7 plant plant NN cord-269992-ruf0vvz4 102 8 derived derive VBN cord-269992-ruf0vvz4 102 9 vaccines vaccine NNS cord-269992-ruf0vvz4 102 10 Clinical clinical JJ cord-269992-ruf0vvz4 102 11 development development NN cord-269992-ruf0vvz4 102 12 of of IN cord-269992-ruf0vvz4 102 13 plant plant NN cord-269992-ruf0vvz4 102 14 - - HYPH cord-269992-ruf0vvz4 102 15 produced produce VBN cord-269992-ruf0vvz4 102 16 recombinant recombinant JJ cord-269992-ruf0vvz4 102 17 pharmaceuticals pharmaceutical NNS cord-269992-ruf0vvz4 102 18 : : : cord-269992-ruf0vvz4 102 19 vaccines vaccine NNS cord-269992-ruf0vvz4 102 20 , , , cord-269992-ruf0vvz4 102 21 antibodies antibody NNS cord-269992-ruf0vvz4 102 22 and and CC cord-269992-ruf0vvz4 102 23 beyond beyond IN cord-269992-ruf0vvz4 102 24 Recent recent JJ cord-269992-ruf0vvz4 102 25 development development NN cord-269992-ruf0vvz4 102 26 and and CC cord-269992-ruf0vvz4 102 27 future future JJ cord-269992-ruf0vvz4 102 28 prospects prospect NNS cord-269992-ruf0vvz4 102 29 of of IN cord-269992-ruf0vvz4 102 30 plant plant NN cord-269992-ruf0vvz4 102 31 - - HYPH cord-269992-ruf0vvz4 102 32 based base VBN cord-269992-ruf0vvz4 102 33 vaccines vaccine NNS cord-269992-ruf0vvz4 102 34 Plant Plant NNP cord-269992-ruf0vvz4 102 35 - - HYPH cord-269992-ruf0vvz4 102 36 based base VBN cord-269992-ruf0vvz4 102 37 vaccines vaccine NNS cord-269992-ruf0vvz4 102 38 against against IN cord-269992-ruf0vvz4 102 39 viruses virus NNS cord-269992-ruf0vvz4 102 40 Plants plant NNS cord-269992-ruf0vvz4 102 41 as as IN cord-269992-ruf0vvz4 102 42 an an DT cord-269992-ruf0vvz4 102 43 alternative alternative JJ cord-269992-ruf0vvz4 102 44 source source NN cord-269992-ruf0vvz4 102 45 of of IN cord-269992-ruf0vvz4 102 46 therapeutic therapeutic JJ cord-269992-ruf0vvz4 102 47 proteins protein NNS cord-269992-ruf0vvz4 102 48 New new JJ cord-269992-ruf0vvz4 102 49 strategies strategy NNS cord-269992-ruf0vvz4 102 50 toward toward IN cord-269992-ruf0vvz4 102 51 edible edible JJ cord-269992-ruf0vvz4 102 52 vaccines vaccine NNS cord-269992-ruf0vvz4 102 53 : : : cord-269992-ruf0vvz4 102 54 an an DT cord-269992-ruf0vvz4 102 55 overview overview NN cord-269992-ruf0vvz4 102 56 Plant plant NN cord-269992-ruf0vvz4 102 57 - - HYPH cord-269992-ruf0vvz4 102 58 made make VBN cord-269992-ruf0vvz4 102 59 vaccines vaccine NNS cord-269992-ruf0vvz4 102 60 and and CC cord-269992-ruf0vvz4 102 61 reagents reagent NNS cord-269992-ruf0vvz4 102 62 for for IN cord-269992-ruf0vvz4 102 63 the the DT cord-269992-ruf0vvz4 102 64 One One NNP cord-269992-ruf0vvz4 102 65 Health Health NNP cord-269992-ruf0vvz4 102 66 initiative initiative NN cord-269992-ruf0vvz4 102 67 Production production NN cord-269992-ruf0vvz4 102 68 of of IN cord-269992-ruf0vvz4 102 69 tetravalent tetravalent NNP cord-269992-ruf0vvz4 102 70 dengue dengue NN cord-269992-ruf0vvz4 102 71 virus virus NN cord-269992-ruf0vvz4 102 72 envelope envelope NN cord-269992-ruf0vvz4 102 73 protein protein NN cord-269992-ruf0vvz4 102 74 domain domain NN cord-269992-ruf0vvz4 102 75 III iii CD cord-269992-ruf0vvz4 102 76 based base VBN cord-269992-ruf0vvz4 102 77 antigens antigen NNS cord-269992-ruf0vvz4 102 78 in in IN cord-269992-ruf0vvz4 102 79 lettuce lettuce NN cord-269992-ruf0vvz4 102 80 chloroplasts chloroplast NNS cord-269992-ruf0vvz4 102 81 and and CC cord-269992-ruf0vvz4 102 82 immunologic immunologic JJ cord-269992-ruf0vvz4 102 83 analysis analysis NN cord-269992-ruf0vvz4 102 84 for for IN cord-269992-ruf0vvz4 102 85 future future JJ cord-269992-ruf0vvz4 102 86 oral oral JJ cord-269992-ruf0vvz4 102 87 vaccine vaccine NN cord-269992-ruf0vvz4 102 88 development development NN cord-269992-ruf0vvz4 102 89 Process Process NNP cord-269992-ruf0vvz4 102 90 development development NN cord-269992-ruf0vvz4 102 91 strategies strategy NNS cord-269992-ruf0vvz4 102 92 in in IN cord-269992-ruf0vvz4 102 93 plant plant NN cord-269992-ruf0vvz4 102 94 molecular molecular JJ cord-269992-ruf0vvz4 102 95 farming farming NN cord-269992-ruf0vvz4 102 96 Farming farming NN cord-269992-ruf0vvz4 102 97 of of IN cord-269992-ruf0vvz4 102 98 plant plant NN cord-269992-ruf0vvz4 102 99 - - HYPH cord-269992-ruf0vvz4 102 100 based base VBN cord-269992-ruf0vvz4 102 101 veterinary veterinary JJ cord-269992-ruf0vvz4 102 102 vaccines vaccine NNS cord-269992-ruf0vvz4 102 103 and and CC cord-269992-ruf0vvz4 102 104 their -PRON- PRP$ cord-269992-ruf0vvz4 102 105 applications application NNS cord-269992-ruf0vvz4 102 106 for for IN cord-269992-ruf0vvz4 102 107 disease disease NN cord-269992-ruf0vvz4 102 108 prevention prevention NN cord-269992-ruf0vvz4 102 109 in in IN cord-269992-ruf0vvz4 102 110 animals animal NNS cord-269992-ruf0vvz4 102 111 Hussein Hussein NNP cord-269992-ruf0vvz4 102 112 S. S. NNP cord-269992-ruf0vvz4 102 113 Plant Plant NNP cord-269992-ruf0vvz4 102 114 - - HYPH cord-269992-ruf0vvz4 102 115 based base VBN cord-269992-ruf0vvz4 102 116 vaccines vaccine NNS cord-269992-ruf0vvz4 102 117 : : : cord-269992-ruf0vvz4 102 118 production production NN cord-269992-ruf0vvz4 102 119 and and CC cord-269992-ruf0vvz4 102 120 challenges challenge VBZ cord-269992-ruf0vvz4 102 121 Needle needle NN cord-269992-ruf0vvz4 102 122 - - HYPH cord-269992-ruf0vvz4 102 123 free free JJ cord-269992-ruf0vvz4 102 124 vaccine vaccine NN cord-269992-ruf0vvz4 102 125 delivery delivery NN cord-269992-ruf0vvz4 102 126 Therapeutic therapeutic JJ cord-269992-ruf0vvz4 102 127 strategies strategy NNS cord-269992-ruf0vvz4 102 128 in in IN cord-269992-ruf0vvz4 102 129 an an DT cord-269992-ruf0vvz4 102 130 outbreak outbreak NN cord-269992-ruf0vvz4 102 131 scenario scenario NN cord-269992-ruf0vvz4 102 132 to to TO cord-269992-ruf0vvz4 102 133 treat treat VB cord-269992-ruf0vvz4 102 134 the the DT cord-269992-ruf0vvz4 102 135 novel novel JJ cord-269992-ruf0vvz4 102 136 coronavirus coronavirus NN cord-269992-ruf0vvz4 102 137 originating originate VBG cord-269992-ruf0vvz4 102 138 in in IN cord-269992-ruf0vvz4 102 139 Wuhan Wuhan NNP cord-269992-ruf0vvz4 102 140 , , , cord-269992-ruf0vvz4 102 141 China China NNP cord-269992-ruf0vvz4 102 142 : : : cord-269992-ruf0vvz4 102 143 version version NN cord-269992-ruf0vvz4 102 144 2 2 CD cord-269992-ruf0vvz4 103 1 Preliminary preliminary JJ cord-269992-ruf0vvz4 103 2 phylogenetic phylogenetic JJ cord-269992-ruf0vvz4 103 3 analysis analysis NN cord-269992-ruf0vvz4 103 4 of of IN cord-269992-ruf0vvz4 103 5 11 11 CD cord-269992-ruf0vvz4 103 6 nCoV-2019 ncov-2019 CD cord-269992-ruf0vvz4 103 7 genomes genome NNS