id	sid	tid	token	lemma	pos
cord-343448-xhm97wy2	1	1	key	key	JJ
cord-343448-xhm97wy2	1	2	:	:	:
cord-343448-xhm97wy2	1	3	cord-343448-xhm97wy2	cord-343448-xhm97wy2	JJ
cord-343448-xhm97wy2	1	4	authors	author	NNS
cord-343448-xhm97wy2	1	5	:	:	:
cord-343448-xhm97wy2	1	6	Rinaldi	Rinaldi	NNP
cord-343448-xhm97wy2	1	7	,	,	,
cord-343448-xhm97wy2	1	8	Andrea	Andrea	NNP
cord-343448-xhm97wy2	1	9	title	title	NN
cord-343448-xhm97wy2	1	10	:	:	:
cord-343448-xhm97wy2	1	11	RNA	RNA	NNP
cord-343448-xhm97wy2	1	12	to	to	IN
cord-343448-xhm97wy2	1	13	the	the	DT
cord-343448-xhm97wy2	1	14	rescue	rescue	NN
cord-343448-xhm97wy2	1	15	:	:	:
cord-343448-xhm97wy2	2	1	RNA	RNA	NNP
cord-343448-xhm97wy2	2	2	is	be	VBZ
cord-343448-xhm97wy2	2	3	one	one	CD
cord-343448-xhm97wy2	2	4	of	of	IN
cord-343448-xhm97wy2	2	5	the	the	DT
cord-343448-xhm97wy2	2	6	most	most	RBS
cord-343448-xhm97wy2	2	7	promising	promising	JJ
cord-343448-xhm97wy2	2	8	targets	target	NNS
cord-343448-xhm97wy2	2	9	for	for	IN
cord-343448-xhm97wy2	2	10	drug	drug	NN
cord-343448-xhm97wy2	2	11	development	development	NN
cord-343448-xhm97wy2	2	12	given	give	VBN
cord-343448-xhm97wy2	2	13	its	-PRON-	PRP$
cord-343448-xhm97wy2	2	14	wide	wide	JJ
cord-343448-xhm97wy2	2	15	variety	variety	NN
cord-343448-xhm97wy2	2	16	of	of	IN
cord-343448-xhm97wy2	2	17	uses	use	NNS
cord-343448-xhm97wy2	2	18	date	date	NN
cord-343448-xhm97wy2	2	19	:	:	:
cord-343448-xhm97wy2	2	20	2020	2020	CD
cord-343448-xhm97wy2	2	21	-	-	HYPH
cord-343448-xhm97wy2	2	22	06	06	CD
cord-343448-xhm97wy2	2	23	-	-	SYM
cord-343448-xhm97wy2	2	24	26	26	CD
cord-343448-xhm97wy2	2	25	journal	journal	NN
cord-343448-xhm97wy2	2	26	:	:	:
cord-343448-xhm97wy2	3	1	EMBO	EMBO	NNP
cord-343448-xhm97wy2	3	2	Rep	Rep	NNP
cord-343448-xhm97wy2	3	3	DOI	DOI	NNP
cord-343448-xhm97wy2	3	4	:	:	:
cord-343448-xhm97wy2	4	1	10.15252	10.15252	CD
cord-343448-xhm97wy2	4	2	/	/	SYM
cord-343448-xhm97wy2	4	3	embr.202051013	embr.202051013	NNP
cord-343448-xhm97wy2	4	4	sha	sha	NNP
cord-343448-xhm97wy2	4	5	:	:	:
cord-343448-xhm97wy2	5	1	7c5eb21b237bc37f81ee57597b698fde5d1f495a	7c5eb21b237bc37f81ee57597b698fde5d1f495a	CD
cord-343448-xhm97wy2	5	2	doc_id	doc_id	CD
cord-343448-xhm97wy2	5	3	:	:	:
cord-343448-xhm97wy2	5	4	343448	343448	CD
cord-343448-xhm97wy2	5	5	cord_uid	cord_uid	NNS
cord-343448-xhm97wy2	5	6	:	:	:
cord-343448-xhm97wy2	5	7	xhm97wy2	xhm97wy2	.
cord-343448-xhm97wy2	6	1	The	the	DT
cord-343448-xhm97wy2	6	2	race	race	NN
cord-343448-xhm97wy2	6	3	for	for	IN
cord-343448-xhm97wy2	6	4	a	a	DT
cord-343448-xhm97wy2	6	5	vaccine	vaccine	NN
cord-343448-xhm97wy2	6	6	against	against	IN
cord-343448-xhm97wy2	6	7	SARS‐CoV‐2	SARS‐CoV‐2	NNP
cord-343448-xhm97wy2	6	8	has	have	VBZ
cord-343448-xhm97wy2	6	9	accelerated	accelerate	VBN
cord-343448-xhm97wy2	6	10	research	research	NN
cord-343448-xhm97wy2	6	11	on	on	IN
cord-343448-xhm97wy2	6	12	RNA‐based	rna‐based	JJ
cord-343448-xhm97wy2	6	13	therapeutics	therapeutic	NNS
cord-343448-xhm97wy2	6	14	.	.	.
cord-343448-xhm97wy2	7	1	Beyond	beyond	IN
cord-343448-xhm97wy2	7	2	vaccines	vaccine	NNS
cord-343448-xhm97wy2	7	3	,	,	,
cord-343448-xhm97wy2	7	4	RNA	RNA	NNP
cord-343448-xhm97wy2	7	5	also	also	RB
cord-343448-xhm97wy2	7	6	shows	show	VBZ
cord-343448-xhm97wy2	7	7	great	great	JJ
cord-343448-xhm97wy2	7	8	potential	potential	NN
cord-343448-xhm97wy2	7	9	for	for	IN
cord-343448-xhm97wy2	7	10	cancer	cancer	NN
cord-343448-xhm97wy2	7	11	therapies.[Image	therapies.[image	NN
cord-343448-xhm97wy2	7	12	:	:	:
cord-343448-xhm97wy2	7	13	see	see	VB
cord-343448-xhm97wy2	7	14	text	text	NN
cord-343448-xhm97wy2	7	15	]	]	-RRB-
cord-343448-xhm97wy2	8	1	A	a	DT
cord-343448-xhm97wy2	8	2	fter	fter	NN
cord-343448-xhm97wy2	8	3	a	a	DT
cord-343448-xhm97wy2	8	4	long	long	JJ
cord-343448-xhm97wy2	8	5	incubation	incubation	NN
cord-343448-xhm97wy2	8	6	time	time	NN
cord-343448-xhm97wy2	8	7	,	,	,
cord-343448-xhm97wy2	8	8	RNAbased	rnabased	JJ
cord-343448-xhm97wy2	8	9	therapeutics	therapeutic	NNS
cord-343448-xhm97wy2	8	10	are	be	VBP
cord-343448-xhm97wy2	8	11	coming	come	VBG
cord-343448-xhm97wy2	8	12	of	of	IN
cord-343448-xhm97wy2	8	13	age	age	NN
cord-343448-xhm97wy2	8	14	and	and	CC
cord-343448-xhm97wy2	8	15	offer	offer	VBP
cord-343448-xhm97wy2	8	16	a	a	DT
cord-343448-xhm97wy2	8	17	big	big	JJ
cord-343448-xhm97wy2	8	18	hope	hope	NN
cord-343448-xhm97wy2	8	19	for	for	IN
cord-343448-xhm97wy2	8	20	an	an	DT
cord-343448-xhm97wy2	8	21	urgently	urgently	RB
cord-343448-xhm97wy2	8	22	needed	need	VBN
cord-343448-xhm97wy2	8	23	SARS	SARS	NNP
cord-343448-xhm97wy2	8	24	-	-	HYPH
cord-343448-xhm97wy2	8	25	CoV-2	CoV-2	NNP
cord-343448-xhm97wy2	8	26	vaccine	vaccine	NN
cord-343448-xhm97wy2	8	27	.	.	.
cord-343448-xhm97wy2	9	1	As	as	IN
cord-343448-xhm97wy2	9	2	the	the	DT
cord-343448-xhm97wy2	9	3	COVID-19	covid-19	JJ
cord-343448-xhm97wy2	9	4	outbreak	outbreak	NN
cord-343448-xhm97wy2	9	5	is	be	VBZ
cord-343448-xhm97wy2	9	6	ravaging	ravage	VBG
cord-343448-xhm97wy2	9	7	communities	community	NNS
cord-343448-xhm97wy2	9	8	worldwide	worldwide	RB
cord-343448-xhm97wy2	9	9	and	and	CC
cord-343448-xhm97wy2	9	10	exacting	exact	VBG
cord-343448-xhm97wy2	9	11	a	a	DT
cord-343448-xhm97wy2	9	12	heavy	heavy	JJ
cord-343448-xhm97wy2	9	13	toll	toll	NN
cord-343448-xhm97wy2	9	14	in	in	IN
cord-343448-xhm97wy2	9	15	terms	term	NNS
cord-343448-xhm97wy2	9	16	of	of	IN
cord-343448-xhm97wy2	9	17	lives	life	NNS
cord-343448-xhm97wy2	9	18	and	and	CC
cord-343448-xhm97wy2	9	19	economic	economic	JJ
cord-343448-xhm97wy2	9	20	costs	cost	NNS
cord-343448-xhm97wy2	10	1	(	(	-LRB-
cord-343448-xhm97wy2	10	2	https://corona	https://corona	``
cord-343448-xhm97wy2	10	3	virus.jhu.edu/)-with	virus.jhu.edu/)-with	NNP
cord-343448-xhm97wy2	10	4	nothing	nothing	NN
cord-343448-xhm97wy2	10	5	to	to	TO
cord-343448-xhm97wy2	10	6	counter	counter	VB
cord-343448-xhm97wy2	10	7	its	-PRON-	PRP$
cord-343448-xhm97wy2	10	8	spreading	spreading	NN
cord-343448-xhm97wy2	10	9	but	but	CC
cord-343448-xhm97wy2	10	10	social	social	JJ
cord-343448-xhm97wy2	10	11	distancing	distancing	NN
cord-343448-xhm97wy2	11	1	-many	-many	NNP
cord-343448-xhm97wy2	11	2	put	put	VBD
cord-343448-xhm97wy2	11	3	their	-PRON-	PRP$
cord-343448-xhm97wy2	11	4	hopes	hope	NNS
cord-343448-xhm97wy2	11	5	on	on	IN
cord-343448-xhm97wy2	11	6	the	the	DT
cord-343448-xhm97wy2	11	7	new	new	JJ
cord-343448-xhm97wy2	11	8	kid	kid	NN
cord-343448-xhm97wy2	11	9	among	among	IN
cord-343448-xhm97wy2	11	10	the	the	DT
cord-343448-xhm97wy2	11	11	therapeutics	therapeutic	NNS
cord-343448-xhm97wy2	11	12	:	:	:
cord-343448-xhm97wy2	11	13	RNA	RNA	NNP
cord-343448-xhm97wy2	11	14	.	.	.
cord-343448-xhm97wy2	12	1	Whether	whether	IN
cord-343448-xhm97wy2	12	2	targeting	target	VBG
cord-343448-xhm97wy2	12	3	nucleic	nucleic	JJ
cord-343448-xhm97wy2	12	4	acids	acid	NNS
cord-343448-xhm97wy2	12	5	or	or	CC
cord-343448-xhm97wy2	12	6	proteins	protein	NNS
cord-343448-xhm97wy2	12	7	,	,	,
cord-343448-xhm97wy2	12	8	RNA	RNA	NNP
cord-343448-xhm97wy2	12	9	therapies	therapy	NNS
cord-343448-xhm97wy2	12	10	are	be	VBP
cord-343448-xhm97wy2	12	11	emerging	emerge	VBG
cord-343448-xhm97wy2	12	12	in	in	IN
cord-343448-xhm97wy2	12	13	the	the	DT
cord-343448-xhm97wy2	12	14	form	form	NN
cord-343448-xhm97wy2	12	15	of	of	IN
cord-343448-xhm97wy2	12	16	a	a	DT
cord-343448-xhm97wy2	12	17	large	large	JJ
cord-343448-xhm97wy2	12	18	platform	platform	NN
cord-343448-xhm97wy2	12	19	rather	rather	RB
cord-343448-xhm97wy2	12	20	than	than	IN
cord-343448-xhm97wy2	12	21	a	a	DT
cord-343448-xhm97wy2	12	22	single	single	JJ
cord-343448-xhm97wy2	12	23	approach	approach	NN
cord-343448-xhm97wy2	12	24	,	,	,
cord-343448-xhm97wy2	12	25	with	with	IN
cord-343448-xhm97wy2	12	26	great	great	JJ
cord-343448-xhm97wy2	12	27	expectations	expectation	NNS
cord-343448-xhm97wy2	12	28	for	for	IN
cord-343448-xhm97wy2	12	29	a	a	DT
cord-343448-xhm97wy2	12	30	new	new	JJ
cord-343448-xhm97wy2	12	31	wave	wave	NN
cord-343448-xhm97wy2	12	32	of	of	IN
cord-343448-xhm97wy2	12	33	drugs	drug	NNS
cord-343448-xhm97wy2	12	34	to	to	TO
cord-343448-xhm97wy2	12	35	treat	treat	VB
cord-343448-xhm97wy2	12	36	a	a	DT
cord-343448-xhm97wy2	12	37	range	range	NN
cord-343448-xhm97wy2	12	38	of	of	IN
cord-343448-xhm97wy2	12	39	ailments	ailment	NNS
cord-343448-xhm97wy2	12	40	.	.	.
cord-343448-xhm97wy2	13	1	Infectious	infectious	JJ
cord-343448-xhm97wy2	13	2	diseases	disease	NNS
cord-343448-xhm97wy2	13	3	,	,	,
cord-343448-xhm97wy2	13	4	cancers	cancer	NNS
cord-343448-xhm97wy2	13	5	,	,	,
cord-343448-xhm97wy2	13	6	rare	rare	JJ
cord-343448-xhm97wy2	13	7	genetic	genetic	JJ
cord-343448-xhm97wy2	13	8	defects	defect	NNS
cord-343448-xhm97wy2	13	9	,	,	,
cord-343448-xhm97wy2	13	10	metabolic	metabolic	JJ
cord-343448-xhm97wy2	13	11	disorders	disorder	NNS
cord-343448-xhm97wy2	13	12	,	,	,
cord-343448-xhm97wy2	13	13	degenerative	degenerative	JJ
cord-343448-xhm97wy2	13	14	diseases	disease	NNS
cord-343448-xhm97wy2	13	15	,	,	,
cord-343448-xhm97wy2	13	16	you	-PRON-	PRP
cord-343448-xhm97wy2	13	17	name	name	VBP
cord-343448-xhm97wy2	13	18	it	-PRON-	PRP
cord-343448-xhm97wy2	13	19	:	:	:
cord-343448-xhm97wy2	13	20	RNA	RNA	NNP
cord-343448-xhm97wy2	13	21	seems	seem	VBZ
cord-343448-xhm97wy2	13	22	to	to	TO
cord-343448-xhm97wy2	13	23	be	be	VB
cord-343448-xhm97wy2	13	24	the	the	DT
cord-343448-xhm97wy2	13	25	solution	solution	NN
cord-343448-xhm97wy2	13	26	for	for	IN
cord-343448-xhm97wy2	13	27	each	each	DT
cord-343448-xhm97wy2	13	28	and	and	CC
cord-343448-xhm97wy2	13	29	every	every	DT
cord-343448-xhm97wy2	13	30	one	one	CD
cord-343448-xhm97wy2	13	31	.	.	.
cord-343448-xhm97wy2	14	1	The	the	DT
cord-343448-xhm97wy2	14	2	metaphor	metaphor	NN
cord-343448-xhm97wy2	14	3	of	of	IN
cord-343448-xhm97wy2	14	4	the	the	DT
cord-343448-xhm97wy2	14	5	Swiss	swiss	JJ
cord-343448-xhm97wy2	14	6	army	army	NN
cord-343448-xhm97wy2	14	7	knife	knife	NN
cord-343448-xhm97wy2	14	8	is	be	VBZ
cord-343448-xhm97wy2	14	9	often	often	RB
cord-343448-xhm97wy2	14	10	abused	abuse	VBN
cord-343448-xhm97wy2	14	11	,	,	,
cord-343448-xhm97wy2	14	12	but	but	CC
cord-343448-xhm97wy2	14	13	it	-PRON-	PRP
cord-343448-xhm97wy2	14	14	fits	fit	VBZ
cord-343448-xhm97wy2	14	15	RNA	RNA	NNP
cord-343448-xhm97wy2	14	16	like	like	IN
cord-343448-xhm97wy2	14	17	a	a	DT
cord-343448-xhm97wy2	14	18	glove	glove	NN
cord-343448-xhm97wy2	14	19	given	give	VBN
cord-343448-xhm97wy2	14	20	the	the	DT
cord-343448-xhm97wy2	14	21	multiple	multiple	JJ
cord-343448-xhm97wy2	14	22	roles	role	NNS
cord-343448-xhm97wy2	14	23	played	play	VBN
cord-343448-xhm97wy2	14	24	by	by	IN
cord-343448-xhm97wy2	14	25	this	this	DT
cord-343448-xhm97wy2	14	26	key	key	JJ
cord-343448-xhm97wy2	14	27	molecule	molecule	NN
cord-343448-xhm97wy2	14	28	:	:	:
cord-343448-xhm97wy2	14	29	messenger	messenger	NNP
cord-343448-xhm97wy2	14	30	RNA	RNA	NNP
cord-343448-xhm97wy2	14	31	(	(	-LRB-
cord-343448-xhm97wy2	14	32	mRNA	mRNA	NNP
cord-343448-xhm97wy2	14	33	)	)	-RRB-
cord-343448-xhm97wy2	14	34	,	,	,
cord-343448-xhm97wy2	14	35	microRNA	microRNA	NNP
cord-343448-xhm97wy2	14	36	(	(	-LRB-
cord-343448-xhm97wy2	14	37	miRNA	miRNA	NNP
cord-343448-xhm97wy2	14	38	)	)	-RRB-
cord-343448-xhm97wy2	14	39	,	,	,
cord-343448-xhm97wy2	14	40	or	or	CC
cord-343448-xhm97wy2	14	41	small	small	JJ
cord-343448-xhm97wy2	14	42	interfering	interfere	VBG
cord-343448-xhm97wy2	14	43	RNA	RNA	NNP
cord-343448-xhm97wy2	14	44	(	(	-LRB-
cord-343448-xhm97wy2	14	45	siRNA	siRNA	NNP
cord-343448-xhm97wy2	14	46	)	)	-RRB-
cord-343448-xhm97wy2	14	47	.	.	.
cord-343448-xhm97wy2	15	1	The	the	DT
cord-343448-xhm97wy2	15	2	beginning	beginning	NN
cord-343448-xhm97wy2	15	3	of	of	IN
cord-343448-xhm97wy2	15	4	the	the	DT
cord-343448-xhm97wy2	15	5	RNA	RNA	NNP
cord-343448-xhm97wy2	15	6	therapies	therapy	NNS
cord-343448-xhm97wy2	15	7	universe	universe	NN
cord-343448-xhm97wy2	15	8	can	can	MD
cord-343448-xhm97wy2	15	9	be	be	VB
cord-343448-xhm97wy2	15	10	safely	safely	RB
cord-343448-xhm97wy2	15	11	placed	place	VBN
cord-343448-xhm97wy2	15	12	in	in	IN
cord-343448-xhm97wy2	15	13	1998	1998	CD
cord-343448-xhm97wy2	15	14	,	,	,
cord-343448-xhm97wy2	15	15	with	with	IN
cord-343448-xhm97wy2	15	16	the	the	DT
cord-343448-xhm97wy2	15	17	discovery	discovery	NN
cord-343448-xhm97wy2	15	18	by	by	IN
cord-343448-xhm97wy2	15	19	Andrew	Andrew	NNP
cord-343448-xhm97wy2	15	20	Fire	Fire	NNP
cord-343448-xhm97wy2	15	21	and	and	CC
cord-343448-xhm97wy2	15	22	Craig	Craig	NNP
cord-343448-xhm97wy2	15	23	Mello	Mello	NNP
cord-343448-xhm97wy2	15	24	of	of	IN
cord-343448-xhm97wy2	15	25	RNA	RNA	NNP
cord-343448-xhm97wy2	15	26	interference	interference	NN
cord-343448-xhm97wy2	15	27	(	(	-LRB-
cord-343448-xhm97wy2	15	28	RNAi	RNAi	NNP
cord-343448-xhm97wy2	15	29	)	)	-RRB-
cord-343448-xhm97wy2	15	30	as	as	IN
cord-343448-xhm97wy2	15	31	a	a	DT
cord-343448-xhm97wy2	15	32	fundamental	fundamental	JJ
cord-343448-xhm97wy2	15	33	mechanism	mechanism	NN
cord-343448-xhm97wy2	15	34	for	for	IN
cord-343448-xhm97wy2	15	35	the	the	DT
cord-343448-xhm97wy2	15	36	regulation	regulation	NN
cord-343448-xhm97wy2	15	37	of	of	IN
cord-343448-xhm97wy2	15	38	gene	gene	NN
cord-343448-xhm97wy2	15	39	expression	expression	NN
cord-343448-xhm97wy2	15	40	.	.	.
cord-343448-xhm97wy2	16	1	In	in	IN
cord-343448-xhm97wy2	16	2	brief	brief	NN
cord-343448-xhm97wy2	16	3	,	,	,
cord-343448-xhm97wy2	16	4	RNAi	RNAi	NNP
cord-343448-xhm97wy2	16	5	works	work	VBZ
cord-343448-xhm97wy2	16	6	through	through	IN
cord-343448-xhm97wy2	16	7	gene	gene	NN
cord-343448-xhm97wy2	16	8	silencing	silencing	NN
cord-343448-xhm97wy2	16	9	,	,	,
cord-343448-xhm97wy2	16	10	degrading	degrade	VBG
cord-343448-xhm97wy2	16	11	the	the	DT
cord-343448-xhm97wy2	16	12	mRNA	mrna	NN
cord-343448-xhm97wy2	16	13	for	for	IN
cord-343448-xhm97wy2	16	14	a	a	DT
cord-343448-xhm97wy2	16	15	specific	specific	JJ
cord-343448-xhm97wy2	16	16	protein	protein	NN
cord-343448-xhm97wy2	16	17	through	through	IN
cord-343448-xhm97wy2	16	18	the	the	DT
cord-343448-xhm97wy2	16	19	coordinated	coordinated	JJ
cord-343448-xhm97wy2	16	20	action	action	NN
cord-343448-xhm97wy2	16	21	of	of	IN
cord-343448-xhm97wy2	16	22	double	double	RB
cord-343448-xhm97wy2	16	23	-	-	HYPH
cord-343448-xhm97wy2	16	24	stranded	strand	VBN
cord-343448-xhm97wy2	16	25	RNA	RNA	NNP
cord-343448-xhm97wy2	16	26	and	and	CC
cord-343448-xhm97wy2	16	27	a	a	DT
cord-343448-xhm97wy2	16	28	complex	complex	JJ
cord-343448-xhm97wy2	16	29	biochemical	biochemical	JJ
cord-343448-xhm97wy2	16	30	machinery	machinery	NN
cord-343448-xhm97wy2	16	31	it	-PRON-	PRP
cord-343448-xhm97wy2	16	32	activates	activate	VBZ
cord-343448-xhm97wy2	17	1	(	(	-LRB-
cord-343448-xhm97wy2	17	2	Fig	Fig	NNP
cord-343448-xhm97wy2	17	3	1	1	CD
cord-343448-xhm97wy2	17	4	)	)	-RRB-
cord-343448-xhm97wy2	17	5	.	.	.
cord-343448-xhm97wy2	18	1	The	the	DT
cord-343448-xhm97wy2	18	2	possibility	possibility	NN
cord-343448-xhm97wy2	18	3	of	of	IN
cord-343448-xhm97wy2	18	4	harnessing	harness	VBG
cord-343448-xhm97wy2	18	5	the	the	DT
cord-343448-xhm97wy2	18	6	newly	newly	RB
cord-343448-xhm97wy2	18	7	identified	identify	VBN
cord-343448-xhm97wy2	18	8	gene	gene	NN
cord-343448-xhm97wy2	18	9	silencing	silencing	NN
cord-343448-xhm97wy2	18	10	mechanism	mechanism	NN
cord-343448-xhm97wy2	18	11	for	for	IN
cord-343448-xhm97wy2	18	12	developing	develop	VBG
cord-343448-xhm97wy2	18	13	innovative	innovative	JJ
cord-343448-xhm97wy2	18	14	therapeutics	therapeutic	NNS
cord-343448-xhm97wy2	18	15	was	be	VBD
cord-343448-xhm97wy2	18	16	soon	soon	RB
cord-343448-xhm97wy2	18	17	evident	evident	JJ
cord-343448-xhm97wy2	18	18	and	and	CC
cord-343448-xhm97wy2	18	19	is	be	VBZ
cord-343448-xhm97wy2	18	20	now	now	RB
cord-343448-xhm97wy2	18	21	finally	finally	RB
cord-343448-xhm97wy2	18	22	becoming	become	VBG
cord-343448-xhm97wy2	18	23	reality	reality	NN
cord-343448-xhm97wy2	18	24	,	,	,
cord-343448-xhm97wy2	18	25	notably	notably	RB
cord-343448-xhm97wy2	18	26	in	in	IN
cord-343448-xhm97wy2	18	27	the	the	DT
cord-343448-xhm97wy2	18	28	form	form	NN
cord-343448-xhm97wy2	18	29	of	of	IN
cord-343448-xhm97wy2	18	30	siRNAs	siRNAs	NNP
cord-343448-xhm97wy2	18	31	,	,	,
cord-343448-xhm97wy2	18	32	synthetic	synthetic	JJ
cord-343448-xhm97wy2	18	33	RNA	RNA	NNP
cord-343448-xhm97wy2	18	34	duplexes	duplex	NNS
cord-343448-xhm97wy2	18	35	usually	usually	RB
cord-343448-xhm97wy2	18	36	21	21	CD
cord-343448-xhm97wy2	18	37	-	-	SYM
cord-343448-xhm97wy2	18	38	25	25	CD
cord-343448-xhm97wy2	18	39	nucleotides	nucleotide	NNS
cord-343448-xhm97wy2	18	40	long	long	JJ
cord-343448-xhm97wy2	18	41	.	.	.
cord-343448-xhm97wy2	19	1	However	however	RB
cord-343448-xhm97wy2	19	2	,	,	,
cord-343448-xhm97wy2	19	3	the	the	DT
cord-343448-xhm97wy2	19	4	road	road	NN
cord-343448-xhm97wy2	19	5	to	to	IN
cord-343448-xhm97wy2	19	6	success	success	NN
cord-343448-xhm97wy2	19	7	was	be	VBD
cord-343448-xhm97wy2	19	8	a	a	DT
cord-343448-xhm97wy2	19	9	bumpy	bumpy	JJ
cord-343448-xhm97wy2	19	10	one	one	NN
cord-343448-xhm97wy2	19	11	.	.	.
cord-343448-xhm97wy2	20	1	After	after	IN
cord-343448-xhm97wy2	20	2	the	the	DT
cord-343448-xhm97wy2	20	3	initial	initial	JJ
cord-343448-xhm97wy2	20	4	excitement	excitement	NN
cord-343448-xhm97wy2	20	5	,	,	,
cord-343448-xhm97wy2	20	6	with	with	IN
cord-343448-xhm97wy2	20	7	lots	lot	NNS
cord-343448-xhm97wy2	20	8	of	of	IN
cord-343448-xhm97wy2	20	9	biotech	biotech	JJ
cord-343448-xhm97wy2	20	10	companies	company	NNS
cord-343448-xhm97wy2	20	11	sprouting	sprout	VBG
cord-343448-xhm97wy2	20	12	around	around	IN
cord-343448-xhm97wy2	20	13	RNAi	RNAi	NNP
cord-343448-xhm97wy2	20	14	discovery	discovery	NN
cord-343448-xhm97wy2	20	15	,	,	,
cord-343448-xhm97wy2	20	16	it	-PRON-	PRP
cord-343448-xhm97wy2	20	17	became	become	VBD
cord-343448-xhm97wy2	20	18	soon	soon	RB
cord-343448-xhm97wy2	20	19	evident	evident	JJ
cord-343448-xhm97wy2	20	20	that	that	IN
cord-343448-xhm97wy2	20	21	it	-PRON-	PRP
cord-343448-xhm97wy2	20	22	was	be	VBD
cord-343448-xhm97wy2	20	23	not	not	RB
cord-343448-xhm97wy2	20	24	an	an	DT
cord-343448-xhm97wy2	20	25	easy	easy	JJ
cord-343448-xhm97wy2	20	26	task	task	NN
cord-343448-xhm97wy2	20	27	.	.	.
cord-343448-xhm97wy2	21	1	Delivering	deliver	VBG
cord-343448-xhm97wy2	21	2	intact	intact	JJ
cord-343448-xhm97wy2	21	3	siRNAs	siRNAs	NNP
cord-343448-xhm97wy2	21	4	into	into	IN
cord-343448-xhm97wy2	21	5	target	target	NN
cord-343448-xhm97wy2	21	6	cells	cell	NNS
cord-343448-xhm97wy2	21	7	and	and	CC
cord-343448-xhm97wy2	21	8	tissues	tissue	NNS
cord-343448-xhm97wy2	21	9	proved	prove	VBD
cord-343448-xhm97wy2	21	10	to	to	TO
cord-343448-xhm97wy2	21	11	be	be	VB
cord-343448-xhm97wy2	21	12	particularly	particularly	RB
cord-343448-xhm97wy2	21	13	challenging	challenging	JJ
cord-343448-xhm97wy2	21	14	.	.	.
cord-343448-xhm97wy2	22	1	A	a	DT
cord-343448-xhm97wy2	22	2	whirl	whirl	NN
cord-343448-xhm97wy2	22	3	of	of	IN
cord-343448-xhm97wy2	22	4	disinvestments	disinvestment	NNS
cord-343448-xhm97wy2	22	5	,	,	,
cord-343448-xhm97wy2	22	6	mergers	merger	NNS
cord-343448-xhm97wy2	22	7	,	,	,
cord-343448-xhm97wy2	22	8	and	and	CC
cord-343448-xhm97wy2	22	9	discounted	discount	VBN
cord-343448-xhm97wy2	22	10	acquisitions	acquisition	NNS
cord-343448-xhm97wy2	22	11	followed	follow	VBD
cord-343448-xhm97wy2	22	12	(	(	-LRB-
cord-343448-xhm97wy2	22	13	Lawrence	Lawrence	NNP
cord-343448-xhm97wy2	22	14	,	,	,
cord-343448-xhm97wy2	22	15	2018	2018	CD
cord-343448-xhm97wy2	22	16	)	)	-RRB-
cord-343448-xhm97wy2	22	17	.	.	.
cord-343448-xhm97wy2	23	1	Despite	despite	IN
cord-343448-xhm97wy2	23	2	all	all	PDT
cord-343448-xhm97wy2	23	3	the	the	DT
cord-343448-xhm97wy2	23	4	setbacks	setback	NNS
cord-343448-xhm97wy2	23	5	,	,	,
cord-343448-xhm97wy2	23	6	the	the	DT
cord-343448-xhm97wy2	23	7	first	first	JJ
cord-343448-xhm97wy2	23	8	therapy	therapy	NN
cord-343448-xhm97wy2	23	9	based	base	VBN
cord-343448-xhm97wy2	23	10	on	on	IN
cord-343448-xhm97wy2	23	11	RNAi	RNAi	NNP
cord-343448-xhm97wy2	23	12	gene	gene	NN
cord-343448-xhm97wy2	23	13	silencing	silencing	NN
cord-343448-xhm97wy2	23	14	was	be	VBD
cord-343448-xhm97wy2	23	15	approved	approve	VBN
cord-343448-xhm97wy2	23	16	in	in	IN
cord-343448-xhm97wy2	23	17	2018	2018	CD
cord-343448-xhm97wy2	23	18	by	by	IN
cord-343448-xhm97wy2	23	19	the	the	DT
cord-343448-xhm97wy2	23	20	FDA	FDA	NNP
cord-343448-xhm97wy2	23	21	.	.	.
cord-343448-xhm97wy2	24	1	The	the	DT
cord-343448-xhm97wy2	24	2	key	key	JJ
cord-343448-xhm97wy2	24	3	molecule	molecule	NN
cord-343448-xhm97wy2	24	4	is	be	VBZ
cord-343448-xhm97wy2	24	5	patisaran	patisaran	JJ
cord-343448-xhm97wy2	24	6	(	(	-LRB-
cord-343448-xhm97wy2	24	7	marketed	market	VBN
cord-343448-xhm97wy2	24	8	as	as	IN
cord-343448-xhm97wy2	24	9	Onpattro	Onpattro	NNP
cord-343448-xhm97wy2	24	10	)	)	-RRB-
cord-343448-xhm97wy2	24	11	,	,	,
cord-343448-xhm97wy2	24	12	a	a	DT
cord-343448-xhm97wy2	24	13	double	double	RB
cord-343448-xhm97wy2	24	14	-	-	HYPH
cord-343448-xhm97wy2	24	15	stranded	strand	VBN
cord-343448-xhm97wy2	24	16	siRNA	siRNA	NNP
cord-343448-xhm97wy2	24	17	to	to	TO
cord-343448-xhm97wy2	24	18	treat	treat	VB
cord-343448-xhm97wy2	24	19	a	a	DT
cord-343448-xhm97wy2	24	20	rare	rare	JJ
cord-343448-xhm97wy2	24	21	and	and	CC
cord-343448-xhm97wy2	24	22	often	often	RB
cord-343448-xhm97wy2	24	23	fatal	fatal	JJ
cord-343448-xhm97wy2	24	24	hereditary	hereditary	JJ
cord-343448-xhm97wy2	24	25	condition	condition	NN
cord-343448-xhm97wy2	24	26	known	know	VBN
cord-343448-xhm97wy2	24	27	as	as	IN
cord-343448-xhm97wy2	24	28	transthyretin	transthyretin	NNP
cord-343448-xhm97wy2	24	29	-	-	HYPH
cord-343448-xhm97wy2	24	30	mediated	mediate	VBN
cord-343448-xhm97wy2	24	31	amyloidosis	amyloidosis	NN
cord-343448-xhm97wy2	24	32	(	(	-LRB-
cord-343448-xhm97wy2	24	33	hATTR	hATTR	NNP
cord-343448-xhm97wy2	24	34	)	)	-RRB-
cord-343448-xhm97wy2	24	35	.	.	.
cord-343448-xhm97wy2	25	1	This	this	DT
cord-343448-xhm97wy2	25	2	progressive	progressive	JJ
cord-343448-xhm97wy2	25	3	degenerative	degenerative	JJ
cord-343448-xhm97wy2	25	4	disease	disease	NN
cord-343448-xhm97wy2	25	5	is	be	VBZ
cord-343448-xhm97wy2	25	6	caused	cause	VBN
cord-343448-xhm97wy2	25	7	by	by	IN
cord-343448-xhm97wy2	25	8	the	the	DT
cord-343448-xhm97wy2	25	9	misfolding	misfolding	NN
cord-343448-xhm97wy2	25	10	of	of	IN
cord-343448-xhm97wy2	25	11	the	the	DT
cord-343448-xhm97wy2	25	12	liver	liver	NN
cord-343448-xhm97wy2	25	13	protein	protein	NN
cord-343448-xhm97wy2	25	14	transthyretin	transthyretin	NNP
cord-343448-xhm97wy2	25	15	(	(	-LRB-
cord-343448-xhm97wy2	25	16	TTR	TTR	NNP
cord-343448-xhm97wy2	25	17	)	)	-RRB-
cord-343448-xhm97wy2	25	18	,	,	,
cord-343448-xhm97wy2	25	19	which	which	WDT
cord-343448-xhm97wy2	25	20	leads	lead	VBZ
cord-343448-xhm97wy2	25	21	to	to	IN
cord-343448-xhm97wy2	25	22	the	the	DT
cord-343448-xhm97wy2	25	23	accumulation	accumulation	NN
cord-343448-xhm97wy2	25	24	of	of	IN
cord-343448-xhm97wy2	25	25	amyloid	amyloid	NN
cord-343448-xhm97wy2	25	26	deposits	deposit	NNS
cord-343448-xhm97wy2	25	27	in	in	IN
cord-343448-xhm97wy2	25	28	the	the	DT
cord-343448-xhm97wy2	25	29	peripheral	peripheral	JJ
cord-343448-xhm97wy2	25	30	nervous	nervous	JJ
cord-343448-xhm97wy2	25	31	system	system	NN
cord-343448-xhm97wy2	25	32	but	but	CC
cord-343448-xhm97wy2	25	33	also	also	RB
cord-343448-xhm97wy2	25	34	in	in	IN
cord-343448-xhm97wy2	25	35	the	the	DT
cord-343448-xhm97wy2	25	36	heart	heart	NN
cord-343448-xhm97wy2	25	37	,	,	,
cord-343448-xhm97wy2	25	38	kidneys	kidney	NNS
cord-343448-xhm97wy2	25	39	,	,	,
cord-343448-xhm97wy2	25	40	eyes	eye	NNS
cord-343448-xhm97wy2	25	41	,	,	,
cord-343448-xhm97wy2	25	42	and	and	CC
cord-343448-xhm97wy2	25	43	gastrointestinal	gastrointestinal	JJ
cord-343448-xhm97wy2	25	44	tract	tract	NN
cord-343448-xhm97wy2	25	45	.	.	.
cord-343448-xhm97wy2	26	1	The	the	DT
cord-343448-xhm97wy2	26	2	drug	drug	NN
cord-343448-xhm97wy2	26	3	uses	use	VBZ
cord-343448-xhm97wy2	26	4	lipid	lipid	NN
cord-343448-xhm97wy2	26	5	nanoparticles	nanoparticle	NNS
cord-343448-xhm97wy2	26	6	as	as	IN
cord-343448-xhm97wy2	26	7	delivery	delivery	NN
cord-343448-xhm97wy2	26	8	system	system	NN
cord-343448-xhm97wy2	26	9	and	and	CC
cord-343448-xhm97wy2	26	10	acts	act	NNS
cord-343448-xhm97wy2	26	11	by	by	IN
cord-343448-xhm97wy2	26	12	inhibiting	inhibit	VBG
cord-343448-xhm97wy2	26	13	the	the	DT
cord-343448-xhm97wy2	26	14	synthesis	synthesis	NN
cord-343448-xhm97wy2	26	15	of	of	IN
cord-343448-xhm97wy2	26	16	TTR	TTR	NNP
cord-343448-xhm97wy2	26	17	,	,	,
cord-343448-xhm97wy2	26	18	thus	thus	RB
cord-343448-xhm97wy2	26	19	reducing	reduce	VBG
cord-343448-xhm97wy2	26	20	the	the	DT
cord-343448-xhm97wy2	26	21	resultant	resultant	JJ
cord-343448-xhm97wy2	26	22	amyloid	amyloid	NN
cord-343448-xhm97wy2	26	23	deposits	deposit	NNS
cord-343448-xhm97wy2	26	24	in	in	IN
cord-343448-xhm97wy2	26	25	the	the	DT
cord-343448-xhm97wy2	26	26	tissues	tissue	NNS
cord-343448-xhm97wy2	27	1	(	(	-LRB-
cord-343448-xhm97wy2	27	2	Akinc	Akinc	NNP
cord-343448-xhm97wy2	27	3	et	et	NNP
cord-343448-xhm97wy2	27	4	al	al	NNP
cord-343448-xhm97wy2	27	5	,	,	,
cord-343448-xhm97wy2	27	6	2019	2019	CD
cord-343448-xhm97wy2	27	7	(	(	-LRB-
cord-343448-xhm97wy2	27	8	Wu	Wu	NNP
cord-343448-xhm97wy2	27	9	&	&	CC
cord-343448-xhm97wy2	27	10	Turnbull	Turnbull	NNP
cord-343448-xhm97wy2	27	11	,	,	,
cord-343448-xhm97wy2	27	12	2018	2018	CD
cord-343448-xhm97wy2	27	13	)	)	-RRB-
cord-343448-xhm97wy2	27	14	.	.	.
cord-343448-xhm97wy2	28	1	Aptamers	aptamer	NNS
cord-343448-xhm97wy2	28	2	are	be	VBP
cord-343448-xhm97wy2	28	3	oligonucleotides	oligonucleotide	NNS
cord-343448-xhm97wy2	28	4	able	able	JJ
cord-343448-xhm97wy2	28	5	to	to	TO
cord-343448-xhm97wy2	28	6	bind	bind	VB
cord-343448-xhm97wy2	28	7	proteins	protein	NNS
cord-343448-xhm97wy2	28	8	with	with	IN
cord-343448-xhm97wy2	28	9	high	high	JJ
cord-343448-xhm97wy2	28	10	affinity	affinity	NN
cord-343448-xhm97wy2	28	11	,	,	,
cord-343448-xhm97wy2	28	12	and	and	CC
cord-343448-xhm97wy2	28	13	pegaptanib	pegaptanib	NN
cord-343448-xhm97wy2	28	14	is	be	VBZ
cord-343448-xhm97wy2	28	15	specifically	specifically	RB
cord-343448-xhm97wy2	28	16	directed	direct	VBN
cord-343448-xhm97wy2	28	17	against	against	IN
cord-343448-xhm97wy2	28	18	VEGF-165	VEGF-165	NNP
cord-343448-xhm97wy2	28	19	,	,	,
cord-343448-xhm97wy2	28	20	an	an	DT
cord-343448-xhm97wy2	28	21	isoform	isoform	NN
cord-343448-xhm97wy2	28	22	of	of	IN
cord-343448-xhm97wy2	28	23	the	the	DT
cord-343448-xhm97wy2	28	24	vascular	vascular	JJ
cord-343448-xhm97wy2	28	25	endothelial	endothelial	JJ
cord-343448-xhm97wy2	28	26	growth	growth	NN
cord-343448-xhm97wy2	28	27	factor	factor	NN
cord-343448-xhm97wy2	28	28	that	that	WDT
cord-343448-xhm97wy2	28	29	plays	play	VBZ
cord-343448-xhm97wy2	28	30	a	a	DT
cord-343448-xhm97wy2	28	31	key	key	JJ
cord-343448-xhm97wy2	28	32	role	role	NN
cord-343448-xhm97wy2	28	33	in	in	IN
cord-343448-xhm97wy2	28	34	AMD	AMD	NNP
cord-343448-xhm97wy2	28	35	vascular	vascular	JJ
cord-343448-xhm97wy2	28	36	pathology	pathology	NN
cord-343448-xhm97wy2	28	37	.	.	.
cord-343448-xhm97wy2	29	1	Two	two	CD
cord-343448-xhm97wy2	29	2	other	other	JJ
cord-343448-xhm97wy2	29	3	RNA	RNA	NNP
cord-343448-xhm97wy2	29	4	drugs	drug	NNS
cord-343448-xhm97wy2	29	5	gained	gain	VBD
cord-343448-xhm97wy2	29	6	FDA	FDA	NNP
cord-343448-xhm97wy2	29	7	approval	approval	NN
cord-343448-xhm97wy2	29	8	in	in	IN
cord-343448-xhm97wy2	29	9	2016	2016	CD
cord-343448-xhm97wy2	29	10	,	,	,
cord-343448-xhm97wy2	29	11	nusinersen	nusinersen	FW
cord-343448-xhm97wy2	29	12	(	(	-LRB-
cord-343448-xhm97wy2	29	13	Spinraza	Spinraza	NNP
cord-343448-xhm97wy2	29	14	)	)	-RRB-
cord-343448-xhm97wy2	29	15	and	and	CC
cord-343448-xhm97wy2	29	16	eteplirsen	eteplirsen	NNP
cord-343448-xhm97wy2	29	17	(	(	-LRB-
cord-343448-xhm97wy2	29	18	Exondys	Exondys	NNP
cord-343448-xhm97wy2	29	19	51	51	CD
cord-343448-xhm97wy2	29	20	)	)	-RRB-
cord-343448-xhm97wy2	29	21	,	,	,
cord-343448-xhm97wy2	29	22	used	use	VBD
cord-343448-xhm97wy2	29	23	to	to	TO
cord-343448-xhm97wy2	29	24	treat	treat	VB
cord-343448-xhm97wy2	29	25	spinal	spinal	JJ
cord-343448-xhm97wy2	29	26	muscular	muscular	JJ
cord-343448-xhm97wy2	29	27	atrophy	atrophy	NN
cord-343448-xhm97wy2	29	28	and	and	CC
cord-343448-xhm97wy2	29	29	Duchenne	Duchenne	NNP
cord-343448-xhm97wy2	29	30	muscular	muscular	JJ
cord-343448-xhm97wy2	29	31	dystrophy	dystrophy	NN
cord-343448-xhm97wy2	29	32	,	,	,
cord-343448-xhm97wy2	29	33	respectively	respectively	RB
cord-343448-xhm97wy2	29	34	.	.	.
cord-343448-xhm97wy2	30	1	Both	both	DT
cord-343448-xhm97wy2	30	2	are	be	VBP
cord-343448-xhm97wy2	30	3	examples	example	NNS
cord-343448-xhm97wy2	30	4	of	of	IN
cord-343448-xhm97wy2	30	5	antisense	antisense	NNP
cord-343448-xhm97wy2	30	6	RNA	RNA	NNP
cord-343448-xhm97wy2	30	7	,	,	,
cord-343448-xhm97wy2	30	8	single	single	RB
cord-343448-xhm97wy2	30	9	-	-	HYPH
cord-343448-xhm97wy2	30	10	stranded	strand	VBN
cord-343448-xhm97wy2	30	11	RNA	RNA	NNP
cord-343448-xhm97wy2	30	12	that	that	WDT
cord-343448-xhm97wy2	30	13	binds	bind	VBZ
cord-343448-xhm97wy2	30	14	to	to	IN
cord-343448-xhm97wy2	30	15	the	the	DT
cord-343448-xhm97wy2	30	16	mRNA	mrna	NN
cord-343448-xhm97wy2	30	17	coding	code	VBG
cord-343448-xhm97wy2	30	18	a	a	DT
cord-343448-xhm97wy2	30	19	protein	protein	NN
cord-343448-xhm97wy2	30	20	involved	involve	VBN
cord-343448-xhm97wy2	30	21	in	in	IN
cord-343448-xhm97wy2	30	22	disease	disease	NN
cord-343448-xhm97wy2	30	23	pathology	pathology	NN
cord-343448-xhm97wy2	30	24	,	,	,
cord-343448-xhm97wy2	30	25	and	and	CC
cord-343448-xhm97wy2	30	26	blocks	block	VBZ
cord-343448-xhm97wy2	30	27	mRNA	mrna	NN
cord-343448-xhm97wy2	30	28	translation	translation	NN
cord-343448-xhm97wy2	30	29	or	or	CC
cord-343448-xhm97wy2	30	30	alters	alter	VBZ
cord-343448-xhm97wy2	30	31	its	-PRON-	PRP$
cord-343448-xhm97wy2	30	32	splicing	splicing	NN
cord-343448-xhm97wy2	30	33	(	(	-LRB-
cord-343448-xhm97wy2	30	34	Wu	Wu	NNP
cord-343448-xhm97wy2	30	35	&	&	CC
cord-343448-xhm97wy2	30	36	Turnbull	Turnbull	NNP
cord-343448-xhm97wy2	30	37	,	,	,
cord-343448-xhm97wy2	30	38	2018	2018	CD
cord-343448-xhm97wy2	30	39	)	)	-RRB-
cord-343448-xhm97wy2	30	40	.	.	.
cord-343448-xhm97wy2	31	1	The	the	DT
cord-343448-xhm97wy2	31	2	future	future	NN
cord-343448-xhm97wy2	31	3	of	of	IN
cord-343448-xhm97wy2	31	4	RNA	RNA	NNP
cord-343448-xhm97wy2	31	5	drugs	drug	NNS
cord-343448-xhm97wy2	31	6	might	may	MD
cord-343448-xhm97wy2	31	7	be	be	VB
cord-343448-xhm97wy2	31	8	bright	bright	JJ
cord-343448-xhm97wy2	31	9	,	,	,
cord-343448-xhm97wy2	31	10	but	but	CC
cord-343448-xhm97wy2	31	11	it	-PRON-	PRP
cord-343448-xhm97wy2	31	12	will	will	MD
cord-343448-xhm97wy2	31	13	be	be	VB
cord-343448-xhm97wy2	31	14	expensive	expensive	JJ
cord-343448-xhm97wy2	31	15	.	.	.
cord-343448-xhm97wy2	31	16	 	 	_SP
cord-343448-xhm97wy2	32	1	When	when	WRB
cord-343448-xhm97wy2	32	2	an	an	DT
cord-343448-xhm97wy2	32	3	RNA	RNA	NNP
cord-343448-xhm97wy2	32	4	virus	virus	NN
cord-343448-xhm97wy2	32	5	infects	infect	VBZ
cord-343448-xhm97wy2	32	6	the	the	DT
cord-343448-xhm97wy2	32	7	cell	cell	NN
cord-343448-xhm97wy2	32	8	,	,	,
cord-343448-xhm97wy2	32	9	it	-PRON-	PRP
cord-343448-xhm97wy2	32	10	injects	inject	VBZ
cord-343448-xhm97wy2	32	11	its	-PRON-	PRP$
cord-343448-xhm97wy2	32	12	genome	genome	NN
cord-343448-xhm97wy2	32	13	consisting	consist	VBG
cord-343448-xhm97wy2	32	14	of	of	IN
cord-343448-xhm97wy2	32	15	double	double	RB
cord-343448-xhm97wy2	32	16	-	-	HYPH
cord-343448-xhm97wy2	32	17	stranded	strand	VBN
cord-343448-xhm97wy2	32	18	RNA	RNA	NNP
cord-343448-xhm97wy2	32	19	.	.	.
cord-343448-xhm97wy2	33	1	RNA	RNA	NNP
cord-343448-xhm97wy2	33	2	interference	interference	NN
cord-343448-xhm97wy2	33	3	destroys	destroy	VBZ
cord-343448-xhm97wy2	33	4	the	the	DT
cord-343448-xhm97wy2	33	5	viral	viral	JJ
cord-343448-xhm97wy2	33	6	RNA	RNA	NNP
cord-343448-xhm97wy2	33	7	,	,	,
cord-343448-xhm97wy2	33	8	preventing	prevent	VBG
cord-343448-xhm97wy2	33	9	the	the	DT
cord-343448-xhm97wy2	33	10	formation	formation	NN
cord-343448-xhm97wy2	33	11	of	of	IN
cord-343448-xhm97wy2	33	12	new	new	JJ
cord-343448-xhm97wy2	33	13	viruses	virus	NNS
cord-343448-xhm97wy2	33	14	.	.	.
cord-343448-xhm97wy2	34	1	A.	A.	NNP
cord-343448-xhm97wy2	34	2	Synthesis	Synthesis	NNP
cord-343448-xhm97wy2	34	3	of	of	IN
cord-343448-xhm97wy2	34	4	many	many	JJ
cord-343448-xhm97wy2	34	5	proteins	protein	NNS
cord-343448-xhm97wy2	34	6	is	be	VBZ
cord-343448-xhm97wy2	34	7	controlled	control	VBN
cord-343448-xhm97wy2	34	8	by	by	IN
cord-343448-xhm97wy2	34	9	genes	gene	NNS
cord-343448-xhm97wy2	34	10	encoding	encode	VBG
cord-343448-xhm97wy2	34	11	microRNA	microRNA	NNP
cord-343448-xhm97wy2	34	12	.	.	.
cord-343448-xhm97wy2	35	1	After	after	IN
cord-343448-xhm97wy2	35	2	processing	processing	NN
cord-343448-xhm97wy2	35	3	,	,	,
cord-343448-xhm97wy2	35	4	microRNA	microRNA	NNP
cord-343448-xhm97wy2	35	5	prevents	prevent	VBZ
cord-343448-xhm97wy2	35	6	the	the	DT
cord-343448-xhm97wy2	35	7	translation	translation	NN
cord-343448-xhm97wy2	35	8	of	of	IN
cord-343448-xhm97wy2	35	9	mRNA	mRNA	NNP
cord-343448-xhm97wy2	35	10	to	to	IN
cord-343448-xhm97wy2	35	11	protein	protein	NN
cord-343448-xhm97wy2	35	12	.	.	.
cord-343448-xhm97wy2	36	1	In	in	IN
cord-343448-xhm97wy2	36	2	the	the	DT
cord-343448-xhm97wy2	36	3	research	research	NN
cord-343448-xhm97wy2	36	4	laboratory	laboratory	NN
cord-343448-xhm97wy2	36	5	,	,	,
cord-343448-xhm97wy2	36	6	dsRNA	dsrna	NN
cord-343448-xhm97wy2	36	7	molecules	molecule	NNS
cord-343448-xhm97wy2	36	8	are	be	VBP
cord-343448-xhm97wy2	36	9	tailor	tailor	NN
cord-343448-xhm97wy2	36	10	-	-	HYPH
cord-343448-xhm97wy2	36	11	made	make	VBN
cord-343448-xhm97wy2	36	12	to	to	TO
cord-343448-xhm97wy2	36	13	activate	activate	VB
cord-343448-xhm97wy2	36	14	the	the	DT
cord-343448-xhm97wy2	36	15	RISC	RISC	NNP
cord-343448-xhm97wy2	36	16	complex	complex	NN
cord-343448-xhm97wy2	36	17	to	to	TO
cord-343448-xhm97wy2	36	18	degrade	degrade	VB
cord-343448-xhm97wy2	36	19	mRNA	mrna	NN
cord-343448-xhm97wy2	36	20	for	for	IN
cord-343448-xhm97wy2	36	21	a	a	DT
cord-343448-xhm97wy2	36	22	specific	specific	JJ
cord-343448-xhm97wy2	36	23	gene	gene	NN
cord-343448-xhm97wy2	36	24	.	.	.
cord-343448-xhm97wy2	37	1	C.	C.	NNP
cord-343448-xhm97wy2	37	2	RNA	RNA	NNP
cord-343448-xhm97wy2	37	3	interference	interference	NN
cord-343448-xhm97wy2	37	4	(	(	-LRB-
cord-343448-xhm97wy2	37	5	RNAi	RNAi	NNP
cord-343448-xhm97wy2	37	6	)	)	-RRB-
cord-343448-xhm97wy2	37	7	is	be	VBZ
cord-343448-xhm97wy2	37	8	an	an	DT
cord-343448-xhm97wy2	37	9	important	important	JJ
cord-343448-xhm97wy2	37	10	biological	biological	JJ
cord-343448-xhm97wy2	37	11	mechanism	mechanism	NN
cord-343448-xhm97wy2	37	12	in	in	IN
cord-343448-xhm97wy2	37	13	the	the	DT
cord-343448-xhm97wy2	37	14	regulation	regulation	NN
cord-343448-xhm97wy2	37	15	of	of	IN
cord-343448-xhm97wy2	37	16	gene	gene	NN
cord-343448-xhm97wy2	37	17	expression	expression	NN
cord-343448-xhm97wy2	37	18	.	.	.
cord-343448-xhm97wy2	38	1	2	2	CD
cord-343448-xhm97wy2	38	2	of	of	IN
cord-343448-xhm97wy2	38	3	6	6	CD
cord-343448-xhm97wy2	38	4	EMBO	EMBO	NNS
cord-343448-xhm97wy2	38	5	reports	report	VBZ
cord-343448-xhm97wy2	38	6	21	21	CD
cord-343448-xhm97wy2	38	7	:	:	:
cord-343448-xhm97wy2	39	1	e51013	e51013	NNP
cord-343448-xhm97wy2	39	2	|	|	NNP
cord-343448-xhm97wy2	39	3	2020	2020	CD
cord-343448-xhm97wy2	39	4	ª	ª	NN
cord-343448-xhm97wy2	39	5	2020	2020	CD
cord-343448-xhm97wy2	40	1	The	the	DT
cord-343448-xhm97wy2	40	2	Author	Author	NNP
cord-343448-xhm97wy2	40	3	treatment	treatment	NN
cord-343448-xhm97wy2	40	4	will	will	MD
cord-343448-xhm97wy2	40	5	need	need	VB
cord-343448-xhm97wy2	40	6	to	to	TO
cord-343448-xhm97wy2	40	7	be	be	VB
cord-343448-xhm97wy2	40	8	maintained	maintain	VBN
cord-343448-xhm97wy2	40	9	for	for	IN
cord-343448-xhm97wy2	40	10	lifetime	lifetime	NN
cord-343448-xhm97wy2	40	11	.	.	.
cord-343448-xhm97wy2	41	1	Exondys	Exondys	NNP
cord-343448-xhm97wy2	41	2	51	51	CD
cord-343448-xhm97wy2	41	3	,	,	,
cord-343448-xhm97wy2	41	4	that	that	WDT
cord-343448-xhm97wy2	41	5	benefitted	benefit	VBD
cord-343448-xhm97wy2	41	6	from	from	IN
cord-343448-xhm97wy2	41	7	an	an	DT
cord-343448-xhm97wy2	41	8	accelerated	accelerated	JJ
cord-343448-xhm97wy2	41	9	approval	approval	NN
cord-343448-xhm97wy2	41	10	process	process	NN
cord-343448-xhm97wy2	41	11	by	by	IN
cord-343448-xhm97wy2	41	12	the	the	DT
cord-343448-xhm97wy2	41	13	FDA	FDA	NNP
cord-343448-xhm97wy2	41	14	,	,	,
cord-343448-xhm97wy2	41	15	can	can	MD
cord-343448-xhm97wy2	41	16	cost	cost	VB
cord-343448-xhm97wy2	41	17	up	up	RP
cord-343448-xhm97wy2	41	18	to	to	TO
cord-343448-xhm97wy2	41	19	US$	us$	$
cord-343448-xhm97wy2	41	20	1	1	CD
cord-343448-xhm97wy2	41	21	million	million	CD
cord-343448-xhm97wy2	41	22	a	a	DT
cord-343448-xhm97wy2	41	23	year	year	NN
cord-343448-xhm97wy2	41	24	.	.	.
cord-343448-xhm97wy2	42	1	"	"	``
cord-343448-xhm97wy2	42	2	One	one	CD
cord-343448-xhm97wy2	42	3	of	of	IN
cord-343448-xhm97wy2	42	4	the	the	DT
cord-343448-xhm97wy2	42	5	top	top	JJ
cord-343448-xhm97wy2	42	6	explanations	explanation	NNS
cord-343448-xhm97wy2	42	7	that	that	IN
cord-343448-xhm97wy2	42	8	drug	drug	NN
cord-343448-xhm97wy2	42	9	companies	company	NNS
cord-343448-xhm97wy2	42	10	give	give	VBP
cord-343448-xhm97wy2	42	11	for	for	IN
cord-343448-xhm97wy2	42	12	the	the	DT
cord-343448-xhm97wy2	42	13	high	high	JJ
cord-343448-xhm97wy2	42	14	cost	cost	NN
cord-343448-xhm97wy2	42	15	of	of	IN
cord-343448-xhm97wy2	42	16	their	-PRON-	PRP$
cord-343448-xhm97wy2	42	17	products	product	NNS
cord-343448-xhm97wy2	42	18	is	be	VBZ
cord-343448-xhm97wy2	42	19	that	that	IN
cord-343448-xhm97wy2	42	20	it	-PRON-	PRP
cord-343448-xhm97wy2	42	21	's	be	VBZ
cord-343448-xhm97wy2	42	22	expensive	expensive	JJ
cord-343448-xhm97wy2	42	23	to	to	TO
cord-343448-xhm97wy2	42	24	get	get	VB
cord-343448-xhm97wy2	42	25	drugs	drug	NNS
cord-343448-xhm97wy2	42	26	through	through	IN
cord-343448-xhm97wy2	42	27	clinical	clinical	JJ
cord-343448-xhm97wy2	42	28	trials	trial	NNS
cord-343448-xhm97wy2	42	29	and	and	CC
cord-343448-xhm97wy2	42	30	across	across	IN
cord-343448-xhm97wy2	42	31	the	the	DT
cord-343448-xhm97wy2	42	32	regulatory	regulatory	JJ
cord-343448-xhm97wy2	42	33	finish	finish	NN
cord-343448-xhm97wy2	42	34	line	line	NN
cord-343448-xhm97wy2	42	35	.	.	.
cord-343448-xhm97wy2	43	1	When	when	WRB
cord-343448-xhm97wy2	43	2	those	those	DT
cord-343448-xhm97wy2	43	3	requirements	requirement	NNS
cord-343448-xhm97wy2	43	4	are	be	VBP
cord-343448-xhm97wy2	43	5	truncated	truncate	VBN
cord-343448-xhm97wy2	43	6	,	,	,
cord-343448-xhm97wy2	43	7	the	the	DT
cord-343448-xhm97wy2	43	8	resulting	result	VBG
cord-343448-xhm97wy2	43	9	drugs	drug	NNS
cord-343448-xhm97wy2	43	10	ought	ought	MD
cord-343448-xhm97wy2	43	11	to	to	TO
cord-343448-xhm97wy2	43	12	cost	cost	VB
cord-343448-xhm97wy2	43	13	less	less	JJR
cord-343448-xhm97wy2	43	14	,	,	,
cord-343448-xhm97wy2	43	15	not	not	RB
cord-343448-xhm97wy2	43	16	more	more	RBR
cord-343448-xhm97wy2	43	17	"	"	''
cord-343448-xhm97wy2	43	18	,	,	,
cord-343448-xhm97wy2	43	19	commented	comment	VBD
cord-343448-xhm97wy2	43	20	the	the	DT
cord-343448-xhm97wy2	43	21	Editorial	Editorial	NNP
cord-343448-xhm97wy2	43	22	Board	Board	NNP
cord-343448-xhm97wy2	43	23	of	of	IN
cord-343448-xhm97wy2	43	24	The	the	DT
cord-343448-xhm97wy2	43	25	New	New	NNP
cord-343448-xhm97wy2	43	26	York	York	NNP
cord-343448-xhm97wy2	43	27	Times	Times	NNP
cord-343448-xhm97wy2	43	28	in	in	IN
cord-343448-xhm97wy2	43	29	an	an	DT
cord-343448-xhm97wy2	43	30	opinion	opinion	NN
cord-343448-xhm97wy2	43	31	article	article	NN
cord-343448-xhm97wy2	43	32	,	,	,
cord-343448-xhm97wy2	43	33	asking	ask	VBG
cord-343448-xhm97wy2	43	34	for	for	IN
cord-343448-xhm97wy2	43	35	price	price	NN
cord-343448-xhm97wy2	43	36	caps	cap	NNS
cord-343448-xhm97wy2	43	37	for	for	IN
cord-343448-xhm97wy2	43	38	drugs	drug	NNS
cord-343448-xhm97wy2	43	39	approved	approve	VBN
cord-343448-xhm97wy2	43	40	with	with	IN
cord-343448-xhm97wy2	43	41	an	an	DT
cord-343448-xhm97wy2	43	42	expedite	expedite	NN
cord-343448-xhm97wy2	43	43	pathway	pathway	NN
cord-343448-xhm97wy2	44	1	(	(	-LRB-
cord-343448-xhm97wy2	44	2	 	 	_SP
cord-343448-xhm97wy2	44	3	Money	Money	NNP
cord-343448-xhm97wy2	44	4	will	will	MD
cord-343448-xhm97wy2	44	5	not	not	RB
cord-343448-xhm97wy2	44	6	be	be	VB
cord-343448-xhm97wy2	44	7	a	a	DT
cord-343448-xhm97wy2	44	8	problem	problem	NN
cord-343448-xhm97wy2	44	9	for	for	IN
cord-343448-xhm97wy2	44	10	developing	develop	VBG
cord-343448-xhm97wy2	44	11	a	a	DT
cord-343448-xhm97wy2	44	12	vaccine	vaccine	NN
cord-343448-xhm97wy2	44	13	against	against	IN
cord-343448-xhm97wy2	44	14	SARS	SARS	NNP
cord-343448-xhm97wy2	44	15	-	-	HYPH
cord-343448-xhm97wy2	44	16	CoV-2	CoV-2	NNP
cord-343448-xhm97wy2	44	17	(	(	-LRB-
cord-343448-xhm97wy2	44	18	Fig	Fig	NNP
cord-343448-xhm97wy2	44	19	2	2	CD
cord-343448-xhm97wy2	44	20	)	)	-RRB-
cord-343448-xhm97wy2	44	21	.	.	.
cord-343448-xhm97wy2	45	1	As	as	IN
cord-343448-xhm97wy2	45	2	the	the	DT
cord-343448-xhm97wy2	45	3	pandemic	pandemic	NN
cord-343448-xhm97wy2	45	4	spreads	spread	VBZ
cord-343448-xhm97wy2	45	5	across	across	IN
cord-343448-xhm97wy2	45	6	the	the	DT
cord-343448-xhm97wy2	45	7	globe	globe	NN
cord-343448-xhm97wy2	45	8	,	,	,
cord-343448-xhm97wy2	45	9	funds	fund	NNS
cord-343448-xhm97wy2	45	10	are	be	VBP
cord-343448-xhm97wy2	45	11	pouring	pour	VBG
cord-343448-xhm97wy2	45	12	from	from	IN
cord-343448-xhm97wy2	45	13	both	both	DT
cord-343448-xhm97wy2	45	14	public	public	JJ
cord-343448-xhm97wy2	45	15	and	and	CC
cord-343448-xhm97wy2	45	16	independent	independent	JJ
cord-343448-xhm97wy2	45	17	sources	source	NNS
cord-343448-xhm97wy2	45	18	.	.	.
cord-343448-xhm97wy2	46	1	The	the	DT
cord-343448-xhm97wy2	46	2	Coalition	Coalition	NNP
cord-343448-xhm97wy2	46	3	for	for	IN
cord-343448-xhm97wy2	46	4	Epidemic	Epidemic	NNP
cord-343448-xhm97wy2	46	5	Preparedness	Preparedness	NNP
cord-343448-xhm97wy2	46	6	Innovations	Innovations	NNPS
cord-343448-xhm97wy2	46	7	(	(	-LRB-
cord-343448-xhm97wy2	46	8	CEPI	CEPI	NNP
cord-343448-xhm97wy2	46	9	)	)	-RRB-
cord-343448-xhm97wy2	46	10	estimated	estimate	VBD
cord-343448-xhm97wy2	46	11	the	the	DT
cord-343448-xhm97wy2	46	12	cost	cost	NN
cord-343448-xhm97wy2	46	13	to	to	TO
cord-343448-xhm97wy2	46	14	develop	develop	VB
cord-343448-xhm97wy2	46	15	such	such	PDT
cord-343448-xhm97wy2	46	16	a	a	DT
cord-343448-xhm97wy2	46	17	vaccine	vaccine	NN
cord-343448-xhm97wy2	46	18	within	within	IN
cord-343448-xhm97wy2	46	19	the	the	DT
cord-343448-xhm97wy2	46	20	next	next	JJ
cord-343448-xhm97wy2	46	21	12	12	CD
cord-343448-xhm97wy2	46	22	-	-	SYM
cord-343448-xhm97wy2	46	23	18	18	CD
cord-343448-xhm97wy2	46	24	months	month	NNS
cord-343448-xhm97wy2	46	25	at	at	IN
cord-343448-xhm97wy2	46	26	US$	us$	$
cord-343448-xhm97wy2	46	27	2	2	CD
cord-343448-xhm97wy2	46	28	billion	billion	CD
cord-343448-xhm97wy2	46	29	(	(	-LRB-
cord-343448-xhm97wy2	46	30	https://cepi.net/covid-19/	https://cepi.net/covid-19/	NFP
cord-343448-xhm97wy2	46	31	)	)	-RRB-
cord-343448-xhm97wy2	46	32	.	.	.
cord-343448-xhm97wy2	47	1	The	the	DT
cord-343448-xhm97wy2	47	2	usual	usual	JJ
cord-343448-xhm97wy2	47	3	time	time	NN
cord-343448-xhm97wy2	47	4	frame	frame	NN
cord-343448-xhm97wy2	47	5	to	to	TO
cord-343448-xhm97wy2	47	6	develop	develop	VB
cord-343448-xhm97wy2	47	7	a	a	DT
cord-343448-xhm97wy2	47	8	vaccine	vaccine	NN
cord-343448-xhm97wy2	47	9	is	be	VBZ
cord-343448-xhm97wy2	47	10	between	between	IN
cord-343448-xhm97wy2	47	11	6	6	CD
cord-343448-xhm97wy2	47	12	and	and	CC
cord-343448-xhm97wy2	47	13	10	10	CD
cord-343448-xhm97wy2	47	14	years	year	NNS
cord-343448-xhm97wy2	47	15	;	;	:
cord-343448-xhm97wy2	47	16	to	to	TO
cord-343448-xhm97wy2	47	17	get	get	VB
cord-343448-xhm97wy2	47	18	a	a	DT
cord-343448-xhm97wy2	47	19	COVID	covid	JJ
cord-343448-xhm97wy2	47	20	vaccine	vaccine	NN
cord-343448-xhm97wy2	47	21	to	to	IN
cord-343448-xhm97wy2	47	22	market	market	NN
cord-343448-xhm97wy2	47	23	,	,	,
cord-343448-xhm97wy2	47	24	so	so	RB
cord-343448-xhm97wy2	47	25	rapidly	rapidly	RB
cord-343448-xhm97wy2	47	26	will	will	MD
cord-343448-xhm97wy2	47	27	therefore	therefore	RB
cord-343448-xhm97wy2	47	28	require	require	VB
cord-343448-xhm97wy2	47	29	regulatory	regulatory	JJ
cord-343448-xhm97wy2	47	30	compression	compression	NN
cord-343448-xhm97wy2	47	31	,	,	,
cord-343448-xhm97wy2	47	32	like	like	IN
cord-343448-xhm97wy2	47	33	shortening	shorten	VBG
cord-343448-xhm97wy2	47	34	animal	animal	NN
cord-343448-xhm97wy2	47	35	tests	test	NNS
cord-343448-xhm97wy2	47	36	.	.	.
cord-343448-xhm97wy2	48	1	In	in	IN
cord-343448-xhm97wy2	48	2	mid	mid	NNP
cord-343448-xhm97wy2	48	3	-	-	NNP
cord-343448-xhm97wy2	48	4	June	June	NNP
cord-343448-xhm97wy2	48	5	this	this	DT
cord-343448-xhm97wy2	48	6	year	year	NN
cord-343448-xhm97wy2	48	7	,	,	,
cord-343448-xhm97wy2	48	8	the	the	DT
cord-343448-xhm97wy2	48	9	World	World	NNP
cord-343448-xhm97wy2	48	10	Health	Health	NNP
cord-343448-xhm97wy2	48	11	Organization	Organization	NNP
cord-343448-xhm97wy2	48	12	(	(	-LRB-
cord-343448-xhm97wy2	48	13	WHO	who	WP
cord-343448-xhm97wy2	48	14	)	)	-RRB-
cord-343448-xhm97wy2	48	15	issued	issue	VBD
cord-343448-xhm97wy2	48	16	a	a	DT
cord-343448-xhm97wy2	48	17	"	"	``
cord-343448-xhm97wy2	48	18	draft	draft	NN
cord-343448-xhm97wy2	48	19	landscape	landscape	NN
cord-343448-xhm97wy2	48	20	of	of	IN
cord-343448-xhm97wy2	48	21	COVID-19	covid-19	JJ
cord-343448-xhm97wy2	48	22	candidate	candidate	NN
cord-343448-xhm97wy2	48	23	vaccines	vaccine	NNS
cord-343448-xhm97wy2	48	24	"	"	''
cord-343448-xhm97wy2	48	25	,	,	,
cord-343448-xhm97wy2	48	26	listing	list	VBG
cord-343448-xhm97wy2	48	27	scores	score	NNS
cord-343448-xhm97wy2	48	28	of	of	IN
cord-343448-xhm97wy2	48	29	products	product	NNS
cord-343448-xhm97wy2	48	30	(	(	-LRB-
cord-343448-xhm97wy2	48	31	the	the	DT
cord-343448-xhm97wy2	48	32	number	number	NN
cord-343448-xhm97wy2	48	33	is	be	VBZ
cord-343448-xhm97wy2	48	34	growing	grow	VBG
cord-343448-xhm97wy2	48	35	by	by	IN
cord-343448-xhm97wy2	48	36	the	the	DT
cord-343448-xhm97wy2	48	37	day	day	NN
cord-343448-xhm97wy2	48	38	)	)	-RRB-
cord-343448-xhm97wy2	48	39	at	at	IN
cord-343448-xhm97wy2	48	40	various	various	JJ
cord-343448-xhm97wy2	48	41	stages	stage	NNS
cord-343448-xhm97wy2	48	42	of	of	IN
cord-343448-xhm97wy2	48	43	clinical	clinical	JJ
cord-343448-xhm97wy2	48	44	development	development	NN
cord-343448-xhm97wy2	48	45	(	(	-LRB-
cord-343448-xhm97wy2	48	46	https://www.who.int/who-documents-deta	https://www.who.int/who-documents-deta	NNP
cord-343448-xhm97wy2	48	47	il	il	NNP
cord-343448-xhm97wy2	48	48	/	/	SYM
cord-343448-xhm97wy2	48	49	draft	draft	NN
cord-343448-xhm97wy2	48	50	-	-	HYPH
cord-343448-xhm97wy2	48	51	landscape	landscape	NN
cord-343448-xhm97wy2	48	52	-	-	HYPH
cord-343448-xhm97wy2	48	53	of	of	IN
cord-343448-xhm97wy2	48	54	-	-	HYPH
cord-343448-xhm97wy2	48	55	covid-19-candidate	covid-19-candidate	NN
cord-343448-xhm97wy2	48	56	-	-	HYPH
cord-343448-xhm97wy2	48	57	vac	vac	NN
cord-343448-xhm97wy2	48	58	cines	cines	NNP
cord-343448-xhm97wy2	48	59	)	)	-RRB-
cord-343448-xhm97wy2	48	60	.	.	.
cord-343448-xhm97wy2	49	1	The	the	DT
cord-343448-xhm97wy2	49	2	aspirant	aspirant	JJ
cord-343448-xhm97wy2	49	3	vaccines	vaccine	NNS
cord-343448-xhm97wy2	49	4	were	be	VBD
cord-343448-xhm97wy2	49	5	grouped	group	VBN
cord-343448-xhm97wy2	49	6	in	in	IN
cord-343448-xhm97wy2	49	7	"	"	``
cord-343448-xhm97wy2	49	8	platforms	platform	NNS
cord-343448-xhm97wy2	49	9	"	"	''
cord-343448-xhm97wy2	49	10	,	,	,
cord-343448-xhm97wy2	49	11	including	include	VBG
cord-343448-xhm97wy2	49	12	protein	protein	NN
cord-343448-xhm97wy2	49	13	subunits	subunit	NNS
cord-343448-xhm97wy2	49	14	,	,	,
cord-343448-xhm97wy2	49	15	DNA	DNA	NNP
cord-343448-xhm97wy2	49	16	,	,	,
cord-343448-xhm97wy2	49	17	RNA	RNA	NNP
cord-343448-xhm97wy2	49	18	,	,	,
cord-343448-xhm97wy2	49	19	and	and	CC
cord-343448-xhm97wy2	49	20	non	non	JJ
cord-343448-xhm97wy2	49	21	-	-	JJ
cord-343448-xhm97wy2	49	22	replicating	replicate	VBG
cord-343448-xhm97wy2	49	23	viral	viral	JJ
cord-343448-xhm97wy2	49	24	vectors	vector	NNS
cord-343448-xhm97wy2	49	25	.	.	.
cord-343448-xhm97wy2	50	1	Several	several	JJ
cord-343448-xhm97wy2	50	2	of	of	IN
cord-343448-xhm97wy2	50	3	the	the	DT
cord-343448-xhm97wy2	50	4	entries	entry	NNS
cord-343448-xhm97wy2	50	5	in	in	IN
cord-343448-xhm97wy2	50	6	the	the	DT
cord-343448-xhm97wy2	50	7	WHO	WHO	NNP
cord-343448-xhm97wy2	50	8	list	list	NN
cord-343448-xhm97wy2	50	9	,	,	,
cord-343448-xhm97wy2	50	10	including	include	VBG
cord-343448-xhm97wy2	50	11	two	two	CD
cord-343448-xhm97wy2	50	12	of	of	IN
cord-343448-xhm97wy2	50	13	the	the	DT
cord-343448-xhm97wy2	50	14	eleven	eleven	CD
cord-343448-xhm97wy2	50	15	in	in	IN
cord-343448-xhm97wy2	50	16	Phase	phase	NN
cord-343448-xhm97wy2	50	17	1/3all	1/3all	CD
cord-343448-xhm97wy2	51	1	the	the	DT
cord-343448-xhm97wy2	51	2	others	other	NNS
cord-343448-xhm97wy2	51	3	are	be	VBP
cord-343448-xhm97wy2	51	4	still	still	RB
cord-343448-xhm97wy2	51	5	in	in	IN
cord-343448-xhm97wy2	51	6	pre	pre	JJ
cord-343448-xhm97wy2	51	7	-	-	JJ
cord-343448-xhm97wy2	51	8	clinical	clinical	JJ
cord-343448-xhm97wy2	51	9	research	research	NN
cord-343448-xhm97wy2	51	10	with	with	IN
cord-343448-xhm97wy2	51	11	a	a	DT
cord-343448-xhm97wy2	51	12	handful	handful	NN
cord-343448-xhm97wy2	51	13	expected	expect	VBN
cord-343448-xhm97wy2	51	14	to	to	TO
cord-343448-xhm97wy2	51	15	enter	enter	VB
cord-343448-xhm97wy2	51	16	clinical	clinical	JJ
cord-343448-xhm97wy2	51	17	trials	trial	NNS
cord-343448-xhm97wy2	51	18	in	in	IN
cord-343448-xhm97wy2	51	19	the	the	DT
cord-343448-xhm97wy2	51	20	next	next	JJ
cord-343448-xhm97wy2	51	21	months	month	NNS
cord-343448-xhm97wy2	51	22	-	-	,
cord-343448-xhm97wy2	51	23	are	be	VBP
cord-343448-xhm97wy2	51	24	mRNA	mrna	NN
cord-343448-xhm97wy2	51	25	-	-	HYPH
cord-343448-xhm97wy2	51	26	based	base	VBN
cord-343448-xhm97wy2	51	27	vaccines	vaccine	NNS
cord-343448-xhm97wy2	51	28	.	.	.
cord-343448-xhm97wy2	52	1	The	the	DT
cord-343448-xhm97wy2	52	2	spearhead	spearhead	NN
cord-343448-xhm97wy2	52	3	is	be	VBZ
cord-343448-xhm97wy2	52	4	mRNA-1273	mrna-1273	XX
cord-343448-xhm97wy2	52	5	,	,	,
cord-343448-xhm97wy2	52	6	which	which	WDT
cord-343448-xhm97wy2	52	7	encodes	encode	VBZ
cord-343448-xhm97wy2	52	8	a	a	DT
cord-343448-xhm97wy2	52	9	prefusion	prefusion	NN
cord-343448-xhm97wy2	52	10	-	-	HYPH
cord-343448-xhm97wy2	52	11	stabilized	stabilize	VBN
cord-343448-xhm97wy2	52	12	form	form	NN
cord-343448-xhm97wy2	52	13	of	of	IN
cord-343448-xhm97wy2	52	14	the	the	DT
cord-343448-xhm97wy2	52	15	spike	spike	NN
cord-343448-xhm97wy2	52	16	(	(	-LRB-
cord-343448-xhm97wy2	52	17	S	s	NN
cord-343448-xhm97wy2	52	18	)	)	-RRB-
cord-343448-xhm97wy2	52	19	protein	protein	NN
cord-343448-xhm97wy2	52	20	of	of	IN
cord-343448-xhm97wy2	52	21	SARS	SARS	NNP
cord-343448-xhm97wy2	52	22	-	-	HYPH
cord-343448-xhm97wy2	52	23	CoV-2	CoV-2	NNP
cord-343448-xhm97wy2	52	24	,	,	,
cord-343448-xhm97wy2	52	25	developed	develop	VBN
cord-343448-xhm97wy2	52	26	at	at	IN
cord-343448-xhm97wy2	52	27	an	an	DT
cord-343448-xhm97wy2	52	28	unusually	unusually	RB
cord-343448-xhm97wy2	52	29	fast	fast	JJ
cord-343448-xhm97wy2	52	30	rate	rate	NN
cord-343448-xhm97wy2	52	31	(	(	-LRB-
cord-343448-xhm97wy2	52	32	first	first	JJ
cord-343448-xhm97wy2	52	33	volunteer	volunteer	NN
cord-343448-xhm97wy2	52	34	injected	inject	VBN
cord-343448-xhm97wy2	52	35	on	on	IN
cord-343448-xhm97wy2	52	36	Mach	Mach	NNP
cord-343448-xhm97wy2	52	37	16	16	CD
cord-343448-xhm97wy2	52	38	,	,	,
cord-343448-xhm97wy2	52	39	only	only	RB
cord-343448-xhm97wy2	52	40	65	65	CD
cord-343448-xhm97wy2	52	41	days	day	NNS
cord-343448-xhm97wy2	52	42	after	after	IN
cord-343448-xhm97wy2	52	43	the	the	DT
cord-343448-xhm97wy2	52	44	publication	publication	NN
cord-343448-xhm97wy2	52	45	of	of	IN
cord-343448-xhm97wy2	52	46	the	the	DT
cord-343448-xhm97wy2	52	47	virus	virus	NN
cord-343448-xhm97wy2	52	48	sequence	sequence	NN
cord-343448-xhm97wy2	52	49	)	)	-RRB-
cord-343448-xhm97wy2	52	50	by	by	IN
cord-343448-xhm97wy2	52	51	Moderna	Moderna	NNP
cord-343448-xhm97wy2	52	52	,	,	,
cord-343448-xhm97wy2	52	53	a	a	DT
cord-343448-xhm97wy2	52	54	biotech	biotech	NN
cord-343448-xhm97wy2	52	55	based	base	VBN
cord-343448-xhm97wy2	52	56	in	in	IN
cord-343448-xhm97wy2	52	57	Cambridge	Cambridge	NNP
cord-343448-xhm97wy2	52	58	,	,	,
cord-343448-xhm97wy2	52	59	Massachusetts	Massachusetts	NNP
cord-343448-xhm97wy2	52	60	(	(	-LRB-
cord-343448-xhm97wy2	52	61	https://www.modernatx.c	https://www.modernatx.c	NN
cord-343448-xhm97wy2	52	62	om/	om/	NN
cord-343448-xhm97wy2	52	63	)	)	-RRB-
cord-343448-xhm97wy2	52	64	.	.	.
cord-343448-xhm97wy2	53	1	In	in	IN
cord-343448-xhm97wy2	53	2	mid	mid	NNP
cord-343448-xhm97wy2	53	3	-	-	NNP
cord-343448-xhm97wy2	53	4	April	April	NNP
cord-343448-xhm97wy2	53	5	this	this	DT
cord-343448-xhm97wy2	53	6	year	year	NN
cord-343448-xhm97wy2	53	7	,	,	,
cord-343448-xhm97wy2	53	8	the	the	DT
cord-343448-xhm97wy2	53	9	company	company	NN
cord-343448-xhm97wy2	53	10	announced	announce	VBD
cord-343448-xhm97wy2	53	11	receiving	receive	VBG
cord-343448-xhm97wy2	53	12	US$	us$	$
cord-343448-xhm97wy2	53	13	483	483	CD
cord-343448-xhm97wy2	53	14	million	million	CD
cord-343448-xhm97wy2	53	15	from	from	IN
cord-343448-xhm97wy2	53	16	the	the	DT
cord-343448-xhm97wy2	53	17	US	US	NNP
cord-343448-xhm97wy2	53	18	Biomedical	Biomedical	NNP
cord-343448-xhm97wy2	53	19	Advanced	Advanced	NNP
cord-343448-xhm97wy2	53	20	Research	Research	NNP
cord-343448-xhm97wy2	53	21	and	and	CC
cord-343448-xhm97wy2	53	22	Development	Development	NNP
cord-343448-xhm97wy2	53	23	Authority	Authority	NNP
cord-343448-xhm97wy2	53	24	(	(	-LRB-
cord-343448-xhm97wy2	53	25	BARDA	BARDA	NNP
cord-343448-xhm97wy2	53	26	)	)	-RRB-
cord-343448-xhm97wy2	53	27	,	,	,
cord-343448-xhm97wy2	53	28	to	to	TO
cord-343448-xhm97wy2	53	29	speed	speed	VB
cord-343448-xhm97wy2	53	30	up	up	RP
cord-343448-xhm97wy2	53	31	the	the	DT
cord-343448-xhm97wy2	53	32	development	development	NN
cord-343448-xhm97wy2	53	33	of	of	IN
cord-343448-xhm97wy2	53	34	its	-PRON-	PRP$
cord-343448-xhm97wy2	53	35	candidate	candidate	NN
cord-343448-xhm97wy2	53	36	.	.	.
cord-343448-xhm97wy2	54	1	"	"	``
cord-343448-xhm97wy2	54	2	If	if	IN
cord-343448-xhm97wy2	54	3	supported	support	VBN
cord-343448-xhm97wy2	54	4	by	by	IN
cord-343448-xhm97wy2	54	5	safety	safety	NN
cord-343448-xhm97wy2	54	6	data	datum	NNS
cord-343448-xhm97wy2	54	7	from	from	IN
cord-343448-xhm97wy2	54	8	the	the	DT
cord-343448-xhm97wy2	54	9	Phase	Phase	NNP
cord-343448-xhm97wy2	54	10	1	1	CD
cord-343448-xhm97wy2	54	11	study	study	NN
cord-343448-xhm97wy2	54	12	,	,	,
cord-343448-xhm97wy2	54	13	the	the	DT
cord-343448-xhm97wy2	54	14	Company	Company	NNP
cord-343448-xhm97wy2	54	15	intends	intend	VBZ
cord-343448-xhm97wy2	54	16	to	to	TO
cord-343448-xhm97wy2	54	17	begin	begin	VB
cord-343448-xhm97wy2	54	18	a	a	DT
cord-343448-xhm97wy2	54	19	Phase	phase	NN
cord-343448-xhm97wy2	54	20	2	2	CD
cord-343448-xhm97wy2	54	21	study	study	NN
cord-343448-xhm97wy2	54	22	of	of	IN
cord-343448-xhm97wy2	54	23	mRNA-1273	mRNA-1273	NNP
cord-343448-xhm97wy2	54	24	.	.	.
cord-343448-xhm97wy2	54	25	.	.	.
cord-343448-xhm97wy2	54	26	..	..	NFP
cord-343448-xhm97wy2	54	27	in	in	IN
cord-343448-xhm97wy2	54	28	the	the	DT
cord-343448-xhm97wy2	54	29	second	second	JJ
cord-343448-xhm97wy2	54	30	quarter	quarter	NN
cord-343448-xhm97wy2	54	31	of	of	IN
cord-343448-xhm97wy2	54	32	2020	2020	CD
cord-343448-xhm97wy2	54	33	"	"	''
cord-343448-xhm97wy2	54	34	,	,	,
cord-343448-xhm97wy2	54	35	reads	read	VBZ
cord-343448-xhm97wy2	54	36	a	a	DT
cord-343448-xhm97wy2	54	37	relevant	relevant	JJ
cord-343448-xhm97wy2	54	38	press	press	NN
cord-343448-xhm97wy2	54	39	release	release	NN
cord-343448-xhm97wy2	54	40	(	(	-LRB-
cord-343448-xhm97wy2	54	41	https://investors.modernatx.c	https://investors.modernatx.c	NNP
cord-343448-xhm97wy2	54	42	om	om	NNP
cord-343448-xhm97wy2	54	43	/	/	SYM
cord-343448-xhm97wy2	54	44	news	news	NN
cord-343448-xhm97wy2	54	45	-	-	HYPH
cord-343448-xhm97wy2	54	46	releases	release	NNS
cord-343448-xhm97wy2	54	47	/	/	SYM
cord-343448-xhm97wy2	54	48	news	news	NN
cord-343448-xhm97wy2	54	49	-	-	HYPH
cord-343448-xhm97wy2	54	50	release	release	NN
cord-343448-xhm97wy2	54	51	-	-	HYPH
cord-343448-xhm97wy2	54	52	details	detail	NNS
cord-343448-xhm97wy2	54	53	/	/	SYM
cord-343448-xhm97wy2	54	54	mod	mod	NNP
cord-343448-xhm97wy2	54	55	erna	erna	NNP
cord-343448-xhm97wy2	54	56	-	-	HYPH
cord-343448-xhm97wy2	54	57	announces	announce	VBZ
cord-343448-xhm97wy2	54	58	-	-	HYPH
cord-343448-xhm97wy2	54	59	award	award	NN
cord-343448-xhm97wy2	54	60	-	-	HYPH
cord-343448-xhm97wy2	54	61	us	-PRON-	PRP
cord-343448-xhm97wy2	54	62	-	-	HYPH
cord-343448-xhm97wy2	54	63	government	government	NN
cord-343448-xhm97wy2	54	64	-	-	HYPH
cord-343448-xhm97wy2	54	65	agencybarda-483-million	agencybarda-483-million	NNP
cord-343448-xhm97wy2	54	66	)	)	-RRB-
cord-343448-xhm97wy2	54	67	.	.	.
cord-343448-xhm97wy2	55	1	"	"	''
cord-343448-xhm97wy2	56	1	Subject	subject	JJ
cord-343448-xhm97wy2	56	2	to	to	IN
cord-343448-xhm97wy2	56	3	data	datum	NNS
cord-343448-xhm97wy2	56	4	from	from	IN
cord-343448-xhm97wy2	56	5	these	these	DT
cord-343448-xhm97wy2	56	6	studies	study	NNS
cord-343448-xhm97wy2	56	7	and	and	CC
cord-343448-xhm97wy2	56	8	discussions	discussion	NNS
cord-343448-xhm97wy2	56	9	with	with	IN
cord-343448-xhm97wy2	56	10	regulators	regulator	NNS
cord-343448-xhm97wy2	56	11	,	,	,
cord-343448-xhm97wy2	56	12	a	a	DT
cord-343448-xhm97wy2	56	13	Phase	phase	NN
cord-343448-xhm97wy2	56	14	3	3	CD
cord-343448-xhm97wy2	56	15	study	study	NN
cord-343448-xhm97wy2	56	16	could	could	MD
cord-343448-xhm97wy2	56	17	begin	begin	VB
cord-343448-xhm97wy2	56	18	as	as	RB
cord-343448-xhm97wy2	56	19	soon	soon	RB
cord-343448-xhm97wy2	56	20	as	as	IN
cord-343448-xhm97wy2	56	21	fall	fall	NN
cord-343448-xhm97wy2	56	22	,	,	,
cord-343448-xhm97wy2	56	23	2020	2020	CD
cord-343448-xhm97wy2	56	24	"	"	''
cord-343448-xhm97wy2	56	25	.	.	.
cord-343448-xhm97wy2	57	1	In	in	IN
cord-343448-xhm97wy2	57	2	mid	mid	JJ
cord-343448-xhm97wy2	57	3	-	-	NNP
cord-343448-xhm97wy2	57	4	May	May	NNP
cord-343448-xhm97wy2	57	5	,	,	,
cord-343448-xhm97wy2	57	6	Moderna	Moderna	NNP
cord-343448-xhm97wy2	57	7	announced	announce	VBD
cord-343448-xhm97wy2	57	8	positive	positive	JJ
cord-343448-xhm97wy2	57	9	interim	interim	JJ
cord-343448-xhm97wy2	57	10	clinical	clinical	JJ
cord-343448-xhm97wy2	57	11	data	datum	NNS
cord-343448-xhm97wy2	57	12	for	for	IN
cord-343448-xhm97wy2	57	13	mRNA-1273	mRNA-1273	NNP
cord-343448-xhm97wy2	57	14	(	(	-LRB-
cord-343448-xhm97wy2	57	15	https://investors.modernatx	https://investors.modernatx	NNP
cord-343448-xhm97wy2	57	16	.	.	.
cord-343448-xhm97wy2	57	17	com	com	NN
cord-343448-xhm97wy2	57	18	/	/	SYM
cord-343448-xhm97wy2	57	19	news	news	NN
cord-343448-xhm97wy2	57	20	-	-	HYPH
cord-343448-xhm97wy2	57	21	releases	release	NNS
cord-343448-xhm97wy2	57	22	/	/	SYM
cord-343448-xhm97wy2	57	23	news	news	NN
cord-343448-xhm97wy2	57	24	-	-	HYPH
cord-343448-xhm97wy2	57	25	release	release	NN
cord-343448-xhm97wy2	57	26	-	-	HYPH
cord-343448-xhm97wy2	57	27	details	detail	NNS
cord-343448-xhm97wy2	57	28	/	/	SYM
cord-343448-xhm97wy2	57	29	mod	mod	NNP
cord-343448-xhm97wy2	57	30	erna	erna	NNP
cord-343448-xhm97wy2	57	31	-	-	HYPH
cord-343448-xhm97wy2	57	32	announces	announce	VBZ
cord-343448-xhm97wy2	57	33	-	-	HYPH
cord-343448-xhm97wy2	57	34	positive	positive	JJ
cord-343448-xhm97wy2	57	35	-	-	HYPH
cord-343448-xhm97wy2	57	36	interim	interim	NN
cord-343448-xhm97wy2	57	37	-	-	HYPH
cord-343448-xhm97wy2	57	38	phase-1-dataits	phase-1-dataits	NN
cord-343448-xhm97wy2	57	39	-	-	HYPH
cord-343448-xhm97wy2	57	40	mrna	mrna	NN
cord-343448-xhm97wy2	57	41	-	-	HYPH
cord-343448-xhm97wy2	57	42	vaccine	vaccine	NN
cord-343448-xhm97wy2	57	43	)	)	-RRB-
cord-343448-xhm97wy2	57	44	.	.	.
cord-343448-xhm97wy2	58	1	Another	another	DT
cord-343448-xhm97wy2	58	2	mRNA	mRNA	NNP
cord-343448-xhm97wy2	58	3	COVID-19	COVID-19	NNP
cord-343448-xhm97wy2	58	4	vaccine	vaccine	NN
cord-343448-xhm97wy2	58	5	program	program	NN
cord-343448-xhm97wy2	58	6	that	that	WDT
cord-343448-xhm97wy2	58	7	has	have	VBZ
cord-343448-xhm97wy2	58	8	recently	recently	RB
cord-343448-xhm97wy2	58	9	started	start	VBN
cord-343448-xhm97wy2	58	10	human	human	JJ
cord-343448-xhm97wy2	58	11	trials	trial	NNS
cord-343448-xhm97wy2	58	12	is	be	VBZ
cord-343448-xhm97wy2	58	13	developed	develop	VBN
cord-343448-xhm97wy2	58	14	by	by	IN
cord-343448-xhm97wy2	58	15	the	the	DT
cord-343448-xhm97wy2	58	16	German	german	JJ
cord-343448-xhm97wy2	58	17	biotech	biotech	NN
cord-343448-xhm97wy2	58	18	company	company	NN
cord-343448-xhm97wy2	58	19	BioNTech	BioNTech	NNS
cord-343448-xhm97wy2	58	20	,	,	,
cord-343448-xhm97wy2	58	21	in	in	IN
cord-343448-xhm97wy2	58	22	collaboration	collaboration	NN
cord-343448-xhm97wy2	58	23	with	with	IN
cord-343448-xhm97wy2	58	24	Pfizer	Pfizer	NNP
cord-343448-xhm97wy2	58	25	(	(	-LRB-
cord-343448-xhm97wy2	58	26	https://investors.biontech.de/newsreleases/news-release-details/pfizer-and-bio	https://investors.biontech.de/newsreleases/news-release-details/pfizer-and-bio	NNP
cord-343448-xhm97wy2	58	27	ntech	ntech	NN
cord-343448-xhm97wy2	58	28	-	-	HYPH
cord-343448-xhm97wy2	58	29	dose	dose	NN
cord-343448-xhm97wy2	58	30	-	-	HYPH
cord-343448-xhm97wy2	58	31	first	first	JJ
cord-343448-xhm97wy2	58	32	-	-	HYPH
cord-343448-xhm97wy2	58	33	participants	participant	NNS
cord-343448-xhm97wy2	58	34	-	-	HYPH
cord-343448-xhm97wy2	58	35	us	-PRON-	PRP
cord-343448-xhm97wy2	58	36	-	-	HYPH
cord-343448-xhm97wy2	58	37	part	part	NN
cord-343448-xhm97wy2	58	38	-	-	HYPH
cord-343448-xhm97wy2	58	39	globalcovid	globalcovid	NNP
cord-343448-xhm97wy2	58	40	)	)	-RRB-
cord-343448-xhm97wy2	58	41	.	.	.
cord-343448-xhm97wy2	59	1	Four	four	CD
cord-343448-xhm97wy2	59	2	vaccine	vaccine	NN
cord-343448-xhm97wy2	59	3	candidates	candidate	NNS
cord-343448-xhm97wy2	59	4	will	will	MD
cord-343448-xhm97wy2	59	5	be	be	VB
cord-343448-xhm97wy2	59	6	studied	study	VBN
cord-343448-xhm97wy2	59	7	,	,	,
cord-343448-xhm97wy2	59	8	two	two	CD
cord-343448-xhm97wy2	59	9	of	of	IN
cord-343448-xhm97wy2	59	10	which	which	WDT
cord-343448-xhm97wy2	59	11	include	include	VBP
cord-343448-xhm97wy2	59	12	a	a	DT
cord-343448-xhm97wy2	59	13	nucleosidemodified	nucleosidemodified	JJ
cord-343448-xhm97wy2	59	14	mRNA	mRNA	NNP
cord-343448-xhm97wy2	59	15	(	(	-LRB-
cord-343448-xhm97wy2	59	16	modRNA	modRNA	NNP
cord-343448-xhm97wy2	59	17	)	)	-RRB-
cord-343448-xhm97wy2	59	18	,	,	,
cord-343448-xhm97wy2	59	19	one	one	CD
cord-343448-xhm97wy2	59	20	a	a	DT
cord-343448-xhm97wy2	59	21	uridinecontaining	uridinecontaine	VBG
cord-343448-xhm97wy2	59	22	mRNA	mrna	NN
cord-343448-xhm97wy2	59	23	(	(	-LRB-
cord-343448-xhm97wy2	59	24	uRNA	urna	CD
cord-343448-xhm97wy2	59	25	)	)	-RRB-
cord-343448-xhm97wy2	59	26	,	,	,
cord-343448-xhm97wy2	59	27	while	while	IN
cord-343448-xhm97wy2	59	28	the	the	DT
cord-343448-xhm97wy2	59	29	fourth	fourth	JJ
cord-343448-xhm97wy2	59	30	vaccine	vaccine	NN
cord-343448-xhm97wy2	59	31	candidate	candidate	NN
cord-343448-xhm97wy2	59	32	utilizes	utilize	VBZ
cord-343448-xhm97wy2	59	33	self	self	NN
cord-343448-xhm97wy2	59	34	-	-	HYPH
cord-343448-xhm97wy2	59	35	amplifying	amplify	VBG
cord-343448-xhm97wy2	59	36	mRNA	mrna	NN
cord-343448-xhm97wy2	59	37	.	.	.
cord-343448-xhm97wy2	60	1	The	the	DT
cord-343448-xhm97wy2	60	2	mRNA	mRNA	NNP
cord-343448-xhm97wy2	60	3	vaccines	vaccine	NNS
cord-343448-xhm97wy2	60	4	against	against	IN
cord-343448-xhm97wy2	60	5	SARS	SARS	NNP
cord-343448-xhm97wy2	60	6	-	-	HYPH
cord-343448-xhm97wy2	60	7	CoV-2	CoV-2	NNP
cord-343448-xhm97wy2	60	8	are	be	VBP
cord-343448-xhm97wy2	60	9	not	not	RB
cord-343448-xhm97wy2	60	10	the	the	DT
cord-343448-xhm97wy2	60	11	first	first	JJ
cord-343448-xhm97wy2	60	12	of	of	IN
cord-343448-xhm97wy2	60	13	their	-PRON-	PRP$
cord-343448-xhm97wy2	60	14	type	type	NN
cord-343448-xhm97wy2	60	15	,	,	,
cord-343448-xhm97wy2	60	16	but	but	CC
cord-343448-xhm97wy2	60	17	rather	rather	RB
cord-343448-xhm97wy2	60	18	the	the	DT
cord-343448-xhm97wy2	60	19	last	last	JJ
cord-343448-xhm97wy2	60	20	shoot	shoot	NN
cord-343448-xhm97wy2	60	21	in	in	IN
cord-343448-xhm97wy2	60	22	a	a	DT
cord-343448-xhm97wy2	60	23	rapidly	rapidly	RB
cord-343448-xhm97wy2	60	24	growing	grow	VBG
cord-343448-xhm97wy2	60	25	tree	tree	NN
cord-343448-xhm97wy2	60	26	(	(	-LRB-
cord-343448-xhm97wy2	60	27	Jackson	Jackson	NNP
cord-343448-xhm97wy2	60	28	et	et	NNP
cord-343448-xhm97wy2	60	29	al	al	NNP
cord-343448-xhm97wy2	60	30	,	,	,
cord-343448-xhm97wy2	60	31	2020	2020	CD
cord-343448-xhm97wy2	60	32	)	)	-RRB-
cord-343448-xhm97wy2	61	1	(	(	-LRB-
cord-343448-xhm97wy2	61	2	Fig	Fig	NNP
cord-343448-xhm97wy2	61	3	3	3	CD
cord-343448-xhm97wy2	61	4	)	)	-RRB-
cord-343448-xhm97wy2	61	5	.	.	.
cord-343448-xhm97wy2	62	1	Although	although	IN
cord-343448-xhm97wy2	62	2	there	there	EX
cord-343448-xhm97wy2	62	3	is	be	VBZ
cord-343448-xhm97wy2	62	4	still	still	RB
cord-343448-xhm97wy2	62	5	no	no	DT
cord-343448-xhm97wy2	62	6	product	product	NN
cord-343448-xhm97wy2	62	7	on	on	IN
cord-343448-xhm97wy2	62	8	the	the	DT
cord-343448-xhm97wy2	62	9	shelves	shelf	NNS
cord-343448-xhm97wy2	62	10	,	,	,
cord-343448-xhm97wy2	62	11	a	a	DT
cord-343448-xhm97wy2	62	12	number	number	NN
cord-343448-xhm97wy2	62	13	of	of	IN
cord-343448-xhm97wy2	62	14	pre	pre	JJ
cord-343448-xhm97wy2	62	15	-	-	JJ
cord-343448-xhm97wy2	62	16	clinical	clinical	JJ
cord-343448-xhm97wy2	62	17	and	and	CC
cord-343448-xhm97wy2	62	18	clinical	clinical	JJ
cord-343448-xhm97wy2	62	19	trials	trial	NNS
cord-343448-xhm97wy2	62	20	have	have	VBP
cord-343448-xhm97wy2	62	21	shown	show	VBN
cord-343448-xhm97wy2	62	22	promising	promising	JJ
cord-343448-xhm97wy2	62	23	results	result	NNS
cord-343448-xhm97wy2	62	24	against	against	IN
cord-343448-xhm97wy2	62	25	a	a	DT
cord-343448-xhm97wy2	62	26	range	range	NN
cord-343448-xhm97wy2	62	27	of	of	IN
cord-343448-xhm97wy2	62	28	infectious	infectious	JJ
cord-343448-xhm97wy2	62	29	diseases	disease	NNS
cord-343448-xhm97wy2	62	30	,	,	,
cord-343448-xhm97wy2	62	31	including	include	VBG
cord-343448-xhm97wy2	62	32	Zika	Zika	NNP
cord-343448-xhm97wy2	62	33	,	,	,
cord-343448-xhm97wy2	62	34	Ebola	Ebola	NNP
cord-343448-xhm97wy2	62	35	,	,	,
cord-343448-xhm97wy2	62	36	dengue	dengue	NN
cord-343448-xhm97wy2	62	37	,	,	,
cord-343448-xhm97wy2	62	38	and	and	CC
cord-343448-xhm97wy2	62	39	papillomavirus	papillomavirus	NN
cord-343448-xhm97wy2	62	40	.	.	.
cord-343448-xhm97wy2	63	1	The	the	DT
cord-343448-xhm97wy2	63	2	main	main	JJ
cord-343448-xhm97wy2	63	3	advantage	advantage	NN
cord-343448-xhm97wy2	63	4	of	of	IN
cord-343448-xhm97wy2	63	5	the	the	DT
cord-343448-xhm97wy2	63	6	mRNA	mRNA	NNP
cord-343448-xhm97wy2	63	7	approach	approach	NN
cord-343448-xhm97wy2	63	8	to	to	IN
cord-343448-xhm97wy2	63	9	vaccine	vaccine	NN
cord-343448-xhm97wy2	63	10	development	development	NN
cord-343448-xhm97wy2	63	11	is	be	VBZ
cord-343448-xhm97wy2	63	12	rapid	rapid	JJ
cord-343448-xhm97wy2	63	13	and	and	CC
cord-343448-xhm97wy2	63	14	scalable	scalable	JJ
cord-343448-xhm97wy2	63	15	manufacturing	manufacturing	NN
cord-343448-xhm97wy2	63	16	,	,	,
cord-343448-xhm97wy2	63	17	a	a	DT
cord-343448-xhm97wy2	63	18	very	very	RB
cord-343448-xhm97wy2	63	19	attractive	attractive	JJ
cord-343448-xhm97wy2	63	20	feature	feature	NN
cord-343448-xhm97wy2	63	21	in	in	IN
cord-343448-xhm97wy2	63	22	times	time	NNS
cord-343448-xhm97wy2	63	23	of	of	IN
cord-343448-xhm97wy2	63	24	epidemic	epidemic	NN
cord-343448-xhm97wy2	63	25	emergency	emergency	NN
cord-343448-xhm97wy2	63	26	.	.	.
cord-343448-xhm97wy2	64	1	Moreover	moreover	RB
cord-343448-xhm97wy2	64	2	,	,	,
cord-343448-xhm97wy2	64	3	RNA	RNA	NNP
cord-343448-xhm97wy2	64	4	vaccines	vaccine	NNS
cord-343448-xhm97wy2	64	5	may	may	MD
cord-343448-xhm97wy2	64	6	be	be	VB
cord-343448-xhm97wy2	64	7	able	able	JJ
cord-343448-xhm97wy2	64	8	to	to	TO
cord-343448-xhm97wy2	64	9	elicit	elicit	VB
cord-343448-xhm97wy2	64	10	a	a	DT
cord-343448-xhm97wy2	64	11	stronger	strong	JJR
cord-343448-xhm97wy2	64	12	and	and	CC
cord-343448-xhm97wy2	64	13	broader	broad	JJR
cord-343448-xhm97wy2	64	14	immune	immune	JJ
cord-343448-xhm97wy2	64	15	response	response	NN
cord-343448-xhm97wy2	64	16	since	since	IN
cord-343448-xhm97wy2	64	17	they	-PRON-	PRP
cord-343448-xhm97wy2	64	18	stimulate	stimulate	VBP
cord-343448-xhm97wy2	64	19	both	both	CC
cord-343448-xhm97wy2	64	20	the	the	DT
cord-343448-xhm97wy2	64	21	adaptive	adaptive	JJ
cord-343448-xhm97wy2	64	22	and	and	CC
cord-343448-xhm97wy2	64	23	innate	innate	JJ
cord-343448-xhm97wy2	64	24	immune	immune	JJ
cord-343448-xhm97wy2	64	25	systems	system	NNS
cord-343448-xhm97wy2	64	26	.	.	.
cord-343448-xhm97wy2	65	1	In	in	IN
cord-343448-xhm97wy2	65	2	addition	addition	NN
cord-343448-xhm97wy2	65	3	,	,	,
cord-343448-xhm97wy2	65	4	RNA	RNA	NNP
cord-343448-xhm97wy2	65	5	vaccines	vaccine	NNS
cord-343448-xhm97wy2	65	6	are	be	VBP
cord-343448-xhm97wy2	65	7	cell	cell	NN
cord-343448-xhm97wy2	65	8	-	-	HYPH
cord-343448-xhm97wy2	65	9	free	free	JJ
cord-343448-xhm97wy2	65	10	,	,	,
cord-343448-xhm97wy2	65	11	non	non	JJ
cord-343448-xhm97wy2	65	12	-	-	JJ
cord-343448-xhm97wy2	65	13	infectious	infectious	JJ
cord-343448-xhm97wy2	65	14	,	,	,
cord-343448-xhm97wy2	65	15	and	and	CC
cord-343448-xhm97wy2	65	16	not	not	RB
cord-343448-xhm97wy2	65	17	-	-	HYPH
cord-343448-xhm97wy2	65	18	integrating	integrate	VBG
cord-343448-xhm97wy2	65	19	,	,	,
cord-343448-xhm97wy2	65	20	thus	thus	RB
cord-343448-xhm97wy2	65	21	eliminating	eliminate	VBG
cord-343448-xhm97wy2	65	22	the	the	DT
cord-343448-xhm97wy2	65	23	risks	risk	NNS
cord-343448-xhm97wy2	65	24	of	of	IN
cord-343448-xhm97wy2	65	25	infection	infection	NN
cord-343448-xhm97wy2	65	26	and	and	CC
cord-343448-xhm97wy2	65	27	insertional	insertional	JJ
cord-343448-xhm97wy2	65	28	mutagenesis	mutagenesis	NN
cord-343448-xhm97wy2	65	29	that	that	WDT
cord-343448-xhm97wy2	65	30	comes	come	VBZ
cord-343448-xhm97wy2	65	31	with	with	IN
cord-343448-xhm97wy2	65	32	viral	viral	JJ
cord-343448-xhm97wy2	65	33	vectors	vector	NNS
cord-343448-xhm97wy2	65	34	.	.	.
cord-343448-xhm97wy2	66	1	Multi	multi	JJ
cord-343448-xhm97wy2	66	2	-	-	JJ
cord-343448-xhm97wy2	66	3	component	component	NN
cord-343448-xhm97wy2	66	4	proteins	protein	NNS
cord-343448-xhm97wy2	66	5	that	that	WDT
cord-343448-xhm97wy2	66	6	would	would	MD
cord-343448-xhm97wy2	66	7	be	be	VB
cord-343448-xhm97wy2	66	8	impossible	impossible	JJ
cord-343448-xhm97wy2	66	9	to	to	TO
cord-343448-xhm97wy2	66	10	target	target	VB
cord-343448-xhm97wy2	66	11	with	with	IN
cord-343448-xhm97wy2	66	12	other	other	JJ
cord-343448-xhm97wy2	66	13	systems	system	NNS
cord-343448-xhm97wy2	66	14	are	be	VBP
cord-343448-xhm97wy2	66	15	accessible	accessible	JJ
cord-343448-xhm97wy2	66	16	with	with	IN
cord-343448-xhm97wy2	66	17	RNA	RNA	NNP
cord-343448-xhm97wy2	66	18	technology	technology	NN
cord-343448-xhm97wy2	66	19	,	,	,
cord-343448-xhm97wy2	66	20	as	as	IN
cord-343448-xhm97wy2	66	21	recently	recently	RB
cord-343448-xhm97wy2	66	22	demonstrated	demonstrate	VBN
cord-343448-xhm97wy2	66	23	by	by	IN
cord-343448-xhm97wy2	66	24	the	the	DT
cord-343448-xhm97wy2	66	25	generation	generation	NN
cord-343448-xhm97wy2	66	26	of	of	IN
cord-343448-xhm97wy2	66	27	a	a	DT
cord-343448-xhm97wy2	66	28	multi	multi	JJ
cord-343448-xhm97wy2	66	29	-	-	JJ
cord-343448-xhm97wy2	66	30	antigenic	antigenic	JJ
cord-343448-xhm97wy2	66	31	mRNA	mRNA	NNP
cord-343448-xhm97wy2	66	32	vaccine	vaccine	NN
cord-343448-xhm97wy2	66	33	encoding	encode	VBG
cord-343448-xhm97wy2	66	34	human	human	JJ
cord-343448-xhm97wy2	66	35	cytomegalovirus	cytomegalovirus	NN
cord-343448-xhm97wy2	66	36	glycoproteins	glycoprotein	NNS
cord-343448-xhm97wy2	66	37	gB	gB	NNP
cord-343448-xhm97wy2	66	38	and	and	CC
cord-343448-xhm97wy2	66	39	pentameric	pentameric	NN
cord-343448-xhm97wy2	66	40	complex	complex	JJ
cord-343448-xhm97wy2	67	1	(	(	-LRB-
cord-343448-xhm97wy2	67	2	John	John	NNP
cord-343448-xhm97wy2	67	3	et	et	NNP
cord-343448-xhm97wy2	67	4	al	al	NNP
cord-343448-xhm97wy2	67	5	,	,	,
cord-343448-xhm97wy2	67	6	2018	2018	CD
cord-343448-xhm97wy2	67	7	)	)	-RRB-
cord-343448-xhm97wy2	67	8	.	.	.
cord-343448-xhm97wy2	68	1	Instability	instability	NN
cord-343448-xhm97wy2	68	2	and	and	CC
cord-343448-xhm97wy2	68	3	inefficient	inefficient	JJ
cord-343448-xhm97wy2	68	4	delivery	delivery	NN
cord-343448-xhm97wy2	68	5	,	,	,
cord-343448-xhm97wy2	68	6	two	two	CD
cord-343448-xhm97wy2	68	7	of	of	IN
cord-343448-xhm97wy2	68	8	the	the	DT
cord-343448-xhm97wy2	68	9	main	main	JJ
cord-343448-xhm97wy2	68	10	hurdles	hurdle	NNS
cord-343448-xhm97wy2	68	11	that	that	WDT
cord-343448-xhm97wy2	68	12	hampered	hamper	VBD
cord-343448-xhm97wy2	68	13	RNA	RNA	NNP
cord-343448-xhm97wy2	68	14	vaccines	vaccine	NNS
cord-343448-xhm97wy2	68	15	success	success	NN
cord-343448-xhm97wy2	68	16	so	so	RB
cord-343448-xhm97wy2	68	17	far	far	RB
cord-343448-xhm97wy2	68	18	,	,	,
cord-343448-xhm97wy2	68	19	have	have	VBP
cord-343448-xhm97wy2	68	20	been	be	VBN
cord-343448-xhm97wy2	68	21	largely	largely	RB
cord-343448-xhm97wy2	68	22	overcome	overcome	VBN
cord-343448-xhm97wy2	68	23	by	by	IN
cord-343448-xhm97wy2	68	24	recent	recent	JJ
cord-343448-xhm97wy2	68	25	improvements	improvement	NNS
cord-343448-xhm97wy2	69	1	(	(	-LRB-
cord-343448-xhm97wy2	69	2	Pardi	Pardi	NNP
cord-343448-xhm97wy2	69	3	et	et	NNP
cord-343448-xhm97wy2	69	4	al	al	NNP
cord-343448-xhm97wy2	69	5	,	,	,
cord-343448-xhm97wy2	69	6	2020	2020	CD
cord-343448-xhm97wy2	69	7	)	)	-RRB-
cord-343448-xhm97wy2	69	8	.	.	.
cord-343448-xhm97wy2	70	1	"	"	''
cord-343448-xhm97wy2	71	1	mRNA	mRNA	NNP
cord-343448-xhm97wy2	71	2	platforms	platform	NNS
cord-343448-xhm97wy2	71	3	can	can	MD
cord-343448-xhm97wy2	71	4	be	be	VB
cord-343448-xhm97wy2	71	5	designed	design	VBN
cord-343448-xhm97wy2	71	6	very	very	RB
cord-343448-xhm97wy2	71	7	fast	fast	RB
cord-343448-xhm97wy2	71	8	to	to	TO
cord-343448-xhm97wy2	71	9	express	express	VB
cord-343448-xhm97wy2	71	10	an	an	DT
cord-343448-xhm97wy2	71	11	optimized	optimize	VBN
cord-343448-xhm97wy2	71	12	version	version	NN
cord-343448-xhm97wy2	71	13	of	of	IN
cord-343448-xhm97wy2	71	14	the	the	DT
cord-343448-xhm97wy2	71	15	gene	gene	NN
cord-343448-xhm97wy2	71	16	of	of	IN
cord-343448-xhm97wy2	71	17	interest	interest	NN
cord-343448-xhm97wy2	71	18	and	and	CC
cord-343448-xhm97wy2	71	19	their	-PRON-	PRP$
cord-343448-xhm97wy2	71	20	production	production	NN
cord-343448-xhm97wy2	71	21	is	be	VBZ
cord-343448-xhm97wy2	71	22	much	much	RB
cord-343448-xhm97wy2	71	23	easier	easy	JJR
cord-343448-xhm97wy2	71	24	than	than	IN
cord-343448-xhm97wy2	71	25	the	the	DT
cord-343448-xhm97wy2	71	26	traditional	traditional	JJ
cord-343448-xhm97wy2	71	27	vaccine	vaccine	NN
cord-343448-xhm97wy2	71	28	platforms	platform	NNS
cord-343448-xhm97wy2	71	29	.	.	.
cord-343448-xhm97wy2	72	1	In	in	IN
cord-343448-xhm97wy2	72	2	addition	addition	NN
cord-343448-xhm97wy2	72	3	,	,	,
cord-343448-xhm97wy2	72	4	you	-PRON-	PRP
cord-343448-xhm97wy2	72	5	can	can	MD
cord-343448-xhm97wy2	72	6	also	also	RB
cord-343448-xhm97wy2	72	7	combine	combine	VB
cord-343448-xhm97wy2	72	8	mRNAs	mrnas	PRP
cord-343448-xhm97wy2	72	9	coding	code	VBG
cord-343448-xhm97wy2	72	10	for	for	IN
cord-343448-xhm97wy2	72	11	multiple	multiple	JJ
cord-343448-xhm97wy2	72	12	antigens	antigen	NNS
cord-343448-xhm97wy2	72	13	to	to	TO
cord-343448-xhm97wy2	72	14	increase	increase	VB
cord-343448-xhm97wy2	72	15	the	the	DT
cord-343448-xhm97wy2	72	16	chance	chance	NN
cord-343448-xhm97wy2	72	17	of	of	IN
cord-343448-xhm97wy2	72	18	inducing	induce	VBG
cord-343448-xhm97wy2	72	19	both	both	DT
cord-343448-xhm97wy2	72	20	production	production	NN
cord-343448-xhm97wy2	72	21	of	of	IN
cord-343448-xhm97wy2	72	22	neutralizing	neutralize	VBG
cord-343448-xhm97wy2	72	23	antibodies	antibody	NNS
cord-343448-xhm97wy2	72	24	and	and	CC
cord-343448-xhm97wy2	72	25	resident	resident	JJ
cord-343448-xhm97wy2	72	26	memory	memory	NN
cord-343448-xhm97wy2	72	27	cytotoxic	cytotoxic	JJ
cord-343448-xhm97wy2	72	28	T	t	NN
cord-343448-xhm97wy2	72	29	cells	cell	NNS
cord-343448-xhm97wy2	72	30	"	"	''
cord-343448-xhm97wy2	72	31	,	,	,
cord-343448-xhm97wy2	72	32	explained	explain	VBD
cord-343448-xhm97wy2	72	33	Chantal	Chantal	NNP
cord-343448-xhm97wy2	72	34	Pichon	Pichon	NNP
cord-343448-xhm97wy2	72	35	,	,	,
cord-343448-xhm97wy2	72	36	a	a	DT
cord-343448-xhm97wy2	72	37	molecular	molecular	JJ
cord-343448-xhm97wy2	72	38	and	and	CC
cord-343448-xhm97wy2	72	39	cell	cell	NN
cord-343448-xhm97wy2	72	40	biologist	biologist	NN
cord-343448-xhm97wy2	72	41	at	at	IN
cord-343448-xhm97wy2	72	42	the	the	DT
cord-343448-xhm97wy2	72	43	French	French	NNP
cord-343448-xhm97wy2	72	44	National	National	NNP
cord-343448-xhm97wy2	72	45	Centre	Centre	NNP
cord-343448-xhm97wy2	72	46	for	for	IN
cord-343448-xhm97wy2	72	47	Scientific	Scientific	NNP
cord-343448-xhm97wy2	72	48	Research	Research	NNP
cord-343448-xhm97wy2	72	49	(	(	-LRB-
cord-343448-xhm97wy2	72	50	CNRS	CNRS	NNP
cord-343448-xhm97wy2	72	51	)	)	-RRB-
cord-343448-xhm97wy2	72	52	in	in	IN
cord-343448-xhm97wy2	72	53	Orléans	Orléans	NNPS
cord-343448-xhm97wy2	72	54	.	.	.
cord-343448-xhm97wy2	73	1	"	"	``
cord-343448-xhm97wy2	73	2	This	this	DT
cord-343448-xhm97wy2	73	3	could	could	MD
cord-343448-xhm97wy2	73	4	be	be	VB
cord-343448-xhm97wy2	73	5	done	do	VBN
cord-343448-xhm97wy2	73	6	through	through	IN
cord-343448-xhm97wy2	73	7	different	different	JJ
cord-343448-xhm97wy2	73	8	mRNAs	mrna	NNS
cord-343448-xhm97wy2	73	9	coding	code	VBG
cord-343448-xhm97wy2	73	10	those	those	DT
cord-343448-xhm97wy2	73	11	antigens	antigen	NNS
cord-343448-xhm97wy2	73	12	or	or	CC
cord-343448-xhm97wy2	73	13	a	a	DT
cord-343448-xhm97wy2	73	14	polycistronic	polycistronic	JJ
cord-343448-xhm97wy2	73	15	mRNA	mrna	NN
cord-343448-xhm97wy2	73	16	coding	code	VBG
cord-343448-xhm97wy2	73	17	the	the	DT
cord-343448-xhm97wy2	73	18	multiple	multiple	JJ
cord-343448-xhm97wy2	73	19	sequences	sequence	NNS
cord-343448-xhm97wy2	73	20	for	for	IN
cord-343448-xhm97wy2	73	21	those	those	DT
cord-343448-xhm97wy2	73	22	antigens	antigen	NNS
cord-343448-xhm97wy2	73	23	"	"	''
cord-343448-xhm97wy2	73	24	.	.	.
cord-343448-xhm97wy2	74	1	However	however	RB
cord-343448-xhm97wy2	74	2	,	,	,
cord-343448-xhm97wy2	74	3	gaps	gap	NNS
cord-343448-xhm97wy2	74	4	still	still	RB
cord-343448-xhm97wy2	74	5	exist	exist	VBP
cord-343448-xhm97wy2	74	6	in	in	IN
cord-343448-xhm97wy2	74	7	our	-PRON-	PRP$
cord-343448-xhm97wy2	74	8	knowledge	knowledge	NN
cord-343448-xhm97wy2	74	9	on	on	IN
cord-343448-xhm97wy2	74	10	how	how	WRB
cord-343448-xhm97wy2	74	11	different	different	JJ
cord-343448-xhm97wy2	74	12	mRNAs	mrna	NNS
cord-343448-xhm97wy2	74	13	are	be	VBP
cord-343448-xhm97wy2	74	14	processed	process	VBN
cord-343448-xhm97wy2	74	15	and	and	CC
cord-343448-xhm97wy2	74	16	sensed	sense	VBN
cord-343448-xhm97wy2	74	17	once	once	IN
cord-343448-xhm97wy2	74	18	they	-PRON-	PRP
cord-343448-xhm97wy2	74	19	are	be	VBP
cord-343448-xhm97wy2	74	20	injected	inject	VBN
cord-343448-xhm97wy2	74	21	,	,	,
cord-343448-xhm97wy2	74	22	which	which	WDT
cord-343448-xhm97wy2	74	23	will	will	MD
cord-343448-xhm97wy2	74	24	require	require	VB
cord-343448-xhm97wy2	74	25	more	more	JJR
cord-343448-xhm97wy2	74	26	basic	basic	JJ
cord-343448-xhm97wy2	74	27	studies	study	NNS
cord-343448-xhm97wy2	74	28	,	,	,
cord-343448-xhm97wy2	74	29	Pichon	Pichon	NNP
cord-343448-xhm97wy2	74	30	warns	warn	VBZ
cord-343448-xhm97wy2	74	31	.	.	.
cord-343448-xhm97wy2	75	1	"	"	``
cord-343448-xhm97wy2	75	2	The	the	DT
cord-343448-xhm97wy2	75	3	fundraising	fundraising	NN
cord-343448-xhm97wy2	75	4	obtained	obtain	VBN
cord-343448-xhm97wy2	75	5	by	by	IN
cord-343448-xhm97wy2	75	6	companies	company	NNS
cord-343448-xhm97wy2	75	7	,	,	,
cord-343448-xhm97wy2	75	8	mostly	mostly	RB
cord-343448-xhm97wy2	75	9	in	in	IN
cord-343448-xhm97wy2	75	10	the	the	DT
cord-343448-xhm97wy2	75	11	US	US	NNP
cord-343448-xhm97wy2	75	12	,	,	,
cord-343448-xhm97wy2	75	13	has	have	VBZ
cord-343448-xhm97wy2	75	14	invigorated	invigorate	VBN
cord-343448-xhm97wy2	75	15	both	both	DT
cord-343448-xhm97wy2	75	16	basic	basic	JJ
cord-343448-xhm97wy2	75	17	ª	ª	NN
cord-343448-xhm97wy2	75	18	2020	2020	CD
cord-343448-xhm97wy2	76	1	The	the	DT
cord-343448-xhm97wy2	76	2	Author	author	NN
cord-343448-xhm97wy2	76	3	EMBO	EMBO	NNP
cord-343448-xhm97wy2	76	4	reports	report	VBZ
cord-343448-xhm97wy2	76	5	21	21	CD
cord-343448-xhm97wy2	76	6	:	:	:
cord-343448-xhm97wy2	77	1	e51013	e51013	NNP
cord-343448-xhm97wy2	77	2	|	|	NNP
cord-343448-xhm97wy2	77	3	2020	2020	CD
cord-343448-xhm97wy2	77	4	and	and	CC
cord-343448-xhm97wy2	77	5	translational	translational	JJ
cord-343448-xhm97wy2	77	6	research	research	NN
cord-343448-xhm97wy2	77	7	around	around	IN
cord-343448-xhm97wy2	77	8	this	this	DT
cord-343448-xhm97wy2	77	9	approach	approach	NN
cord-343448-xhm97wy2	77	10	,	,	,
cord-343448-xhm97wy2	78	1	which	which	WDT
cord-343448-xhm97wy2	78	2	can	can	MD
cord-343448-xhm97wy2	78	3	be	be	VB
cord-343448-xhm97wy2	78	4	applied	apply	VBN
cord-343448-xhm97wy2	78	5	beyond	beyond	IN
cord-343448-xhm97wy2	78	6	vaccination	vaccination	NN
cord-343448-xhm97wy2	78	7	"	"	''
cord-343448-xhm97wy2	78	8	,	,	,
cord-343448-xhm97wy2	78	9	Pichon	Pichon	NNP
cord-343448-xhm97wy2	78	10	concludes	conclude	VBZ
cord-343448-xhm97wy2	78	11	.	.	.
cord-343448-xhm97wy2	79	1	"	"	``
cord-343448-xhm97wy2	79	2	For	for	IN
cord-343448-xhm97wy2	79	3	sure	sure	JJ
cord-343448-xhm97wy2	79	4	,	,	,
cord-343448-xhm97wy2	79	5	mRNAs	mrnas	PRP
cord-343448-xhm97wy2	79	6	hold	hold	VBP
cord-343448-xhm97wy2	79	7	a	a	DT
cord-343448-xhm97wy2	79	8	real	real	JJ
cord-343448-xhm97wy2	79	9	promise	promise	NN
cord-343448-xhm97wy2	79	10	as	as	IN
cord-343448-xhm97wy2	79	11	biopharmaceuticals	biopharmaceutical	NNS
cord-343448-xhm97wy2	79	12	for	for	IN
cord-343448-xhm97wy2	79	13	the	the	DT
cord-343448-xhm97wy2	79	14	years	year	NNS
cord-343448-xhm97wy2	79	15	to	to	TO
cord-343448-xhm97wy2	79	16	come	come	VB
cord-343448-xhm97wy2	79	17	"	"	''
cord-343448-xhm97wy2	79	18	.	.	.
cord-343448-xhm97wy2	80	1	However	however	RB
cord-343448-xhm97wy2	80	2	,	,	,
cord-343448-xhm97wy2	80	3	despite	despite	IN
cord-343448-xhm97wy2	80	4	the	the	DT
cord-343448-xhm97wy2	80	5	urgency	urgency	NN
cord-343448-xhm97wy2	80	6	dictated	dictate	VBN
cord-343448-xhm97wy2	80	7	by	by	IN
cord-343448-xhm97wy2	80	8	the	the	DT
cord-343448-xhm97wy2	80	9	COVID-19	COVID-19	NNP
cord-343448-xhm97wy2	80	10	pandemic	pandemic	NN
cord-343448-xhm97wy2	80	11	and	and	CC
cord-343448-xhm97wy2	80	12	various	various	JJ
cord-343448-xhm97wy2	80	13	calls	call	NNS
cord-343448-xhm97wy2	80	14	for	for	IN
cord-343448-xhm97wy2	80	15	international	international	JJ
cord-343448-xhm97wy2	80	16	collaboration	collaboration	NN
cord-343448-xhm97wy2	80	17	and	and	CC
cord-343448-xhm97wy2	80	18	data	datum	NNS
cord-343448-xhm97wy2	80	19	sharing	sharing	NN
cord-343448-xhm97wy2	80	20	in	in	IN
cord-343448-xhm97wy2	80	21	order	order	NN
cord-343448-xhm97wy2	80	22	to	to	TO
cord-343448-xhm97wy2	80	23	"	"	``
cord-343448-xhm97wy2	80	24	reduce	reduce	VB
cord-343448-xhm97wy2	80	25	inefficiencies	inefficiency	NNS
cord-343448-xhm97wy2	80	26	and	and	CC
cord-343448-xhm97wy2	80	27	duplication	duplication	NN
cord-343448-xhm97wy2	80	28	of	of	IN
cord-343448-xhm97wy2	80	29	effort	effort	NN
cord-343448-xhm97wy2	80	30	"	"	''
cord-343448-xhm97wy2	80	31	(	(	-LRB-
cord-343448-xhm97wy2	80	32	https://www.who.int/ne	https://www.who.int/ne	NNP
cord-343448-xhm97wy2	80	33	ws	ws	NN
cord-343448-xhm97wy2	80	34	-	-	HYPH
cord-343448-xhm97wy2	80	35	room	room	NN
cord-343448-xhm97wy2	80	36	/	/	SYM
cord-343448-xhm97wy2	80	37	detail/13	detail/13	NN
cord-343448-xhm97wy2	80	38	-	-	HYPH
cord-343448-xhm97wy2	80	39	04	04	CD
cord-343448-xhm97wy2	80	40	-	-	HYPH
cord-343448-xhm97wy2	80	41	2020-public	2020-public	CD
cord-343448-xhm97wy2	80	42	-	-	HYPH
cord-343448-xhm97wy2	80	43	statementfor	statementfor	NN
cord-343448-xhm97wy2	80	44	-	-	HYPH
cord-343448-xhm97wy2	80	45	collaboration	collaboration	NN
cord-343448-xhm97wy2	80	46	-	-	HYPH
cord-343448-xhm97wy2	80	47	on	on	IN
cord-343448-xhm97wy2	80	48	-	-	HYPH
cord-343448-xhm97wy2	80	49	covid-19-vaccine	covid-19-vaccine	NNP
cord-343448-xhm97wy2	80	50	-	-	HYPH
cord-343448-xhm97wy2	80	51	deve	deve	NNP
cord-343448-xhm97wy2	80	52	lopment	lopment	NNP
cord-343448-xhm97wy2	80	53	)	)	-RRB-
cord-343448-xhm97wy2	80	54	,	,	,
cord-343448-xhm97wy2	80	55	the	the	DT
cord-343448-xhm97wy2	80	56	landscape	landscape	NN
cord-343448-xhm97wy2	80	57	looks	look	VBZ
cord-343448-xhm97wy2	80	58	much	much	RB
cord-343448-xhm97wy2	80	59	fragmented	fragmented	JJ
cord-343448-xhm97wy2	80	60	,	,	,
cord-343448-xhm97wy2	80	61	with	with	IN
cord-343448-xhm97wy2	80	62	probably	probably	RB
cord-343448-xhm97wy2	80	63	too	too	RB
cord-343448-xhm97wy2	80	64	many	many	JJ
cord-343448-xhm97wy2	80	65	candidate	candidate	NN
cord-343448-xhm97wy2	80	66	vaccines	vaccine	NNS
cord-343448-xhm97wy2	80	67	being	be	VBG
cord-343448-xhm97wy2	80	68	pushed	push	VBN
cord-343448-xhm97wy2	80	69	forward	forward	RB
cord-343448-xhm97wy2	80	70	,	,	,
cord-343448-xhm97wy2	80	71	and	and	CC
cord-343448-xhm97wy2	80	72	a	a	DT
cord-343448-xhm97wy2	80	73	risk	risk	NN
cord-343448-xhm97wy2	80	74	of	of	IN
cord-343448-xhm97wy2	80	75	dispersing	disperse	VBG
cord-343448-xhm97wy2	80	76	much	much	JJ
cord-343448-xhm97wy2	80	77	needed	need	VBN
cord-343448-xhm97wy2	80	78	resources	resource	NNS
cord-343448-xhm97wy2	80	79	(	(	-LRB-
cord-343448-xhm97wy2	80	80	Berkley	Berkley	NNP
cord-343448-xhm97wy2	80	81	,	,	,
cord-343448-xhm97wy2	80	82	2020	2020	CD
cord-343448-xhm97wy2	80	83	)	)	-RRB-
cord-343448-xhm97wy2	80	84	.	.	.
cord-343448-xhm97wy2	81	1	The	the	DT
cord-343448-xhm97wy2	81	2	consequences	consequence	NNS
cord-343448-xhm97wy2	81	3	of	of	IN
cord-343448-xhm97wy2	81	4	failure	failure	NN
cord-343448-xhm97wy2	81	5	would	would	MD
cord-343448-xhm97wy2	81	6	be	be	VB
cord-343448-xhm97wy2	81	7	dreadful	dreadful	JJ
cord-343448-xhm97wy2	81	8	.	.	.
cord-343448-xhm97wy2	81	9	"	"	''
cord-343448-xhm97wy2	82	1	Novel	novel	JJ
cord-343448-xhm97wy2	82	2	infectious	infectious	JJ
cord-343448-xhm97wy2	82	3	diseases	disease	NNS
cord-343448-xhm97wy2	82	4	resulting	result	VBG
cord-343448-xhm97wy2	82	5	from	from	IN
cord-343448-xhm97wy2	82	6	RNA	RNA	NNP
cord-343448-xhm97wy2	82	7	viruses	virus	NNS
cord-343448-xhm97wy2	82	8	subject	subject	JJ
cord-343448-xhm97wy2	82	9	to	to	IN
cord-343448-xhm97wy2	82	10	mutation	mutation	NN
cord-343448-xhm97wy2	82	11	and	and	CC
cord-343448-xhm97wy2	82	12	genetic	genetic	JJ
cord-343448-xhm97wy2	82	13	recombination	recombination	NN
cord-343448-xhm97wy2	82	14	,	,	,
cord-343448-xhm97wy2	82	15	as	as	RB
cord-343448-xhm97wy2	82	16	well	well	RB
cord-343448-xhm97wy2	82	17	as	as	IN
cord-343448-xhm97wy2	82	18	cross	cross	JJ
cord-343448-xhm97wy2	82	19	-	-	JJ
cord-343448-xhm97wy2	82	20	species	species	JJ
cord-343448-xhm97wy2	82	21	transmission	transmission	NN
cord-343448-xhm97wy2	82	22	,	,	,
cord-343448-xhm97wy2	82	23	will	will	MD
cord-343448-xhm97wy2	82	24	continue	continue	VB
cord-343448-xhm97wy2	82	25	to	to	TO
cord-343448-xhm97wy2	82	26	present	present	VB
cord-343448-xhm97wy2	82	27	a	a	DT
cord-343448-xhm97wy2	82	28	serious	serious	JJ
cord-343448-xhm97wy2	82	29	global	global	JJ
cord-343448-xhm97wy2	82	30	health	health	NN
cord-343448-xhm97wy2	82	31	threat	threat	NN
cord-343448-xhm97wy2	82	32	,	,	,
cord-343448-xhm97wy2	82	33	as	as	IN
cord-343448-xhm97wy2	82	34	exemplified	exemplify	VBN
cord-343448-xhm97wy2	82	35	by	by	IN
cord-343448-xhm97wy2	82	36	COVID-19	COVID-19	NNP
cord-343448-xhm97wy2	82	37	"	"	''
cord-343448-xhm97wy2	82	38	,	,	,
cord-343448-xhm97wy2	82	39	recently	recently	RB
cord-343448-xhm97wy2	82	40	remarked	remark	VBD
cord-343448-xhm97wy2	82	41	Cynthia	Cynthia	NNP
cord-343448-xhm97wy2	82	42	Liu	Liu	NNP
cord-343448-xhm97wy2	82	43	and	and	CC
cord-343448-xhm97wy2	82	44	colleagues	colleague	NNS
cord-343448-xhm97wy2	82	45	at	at	IN
cord-343448-xhm97wy2	82	46	the	the	DT
cord-343448-xhm97wy2	82	47	American	American	NNP
cord-343448-xhm97wy2	82	48	Chemical	Chemical	NNP
cord-343448-xhm97wy2	82	49	Society	Society	NNP
cord-343448-xhm97wy2	83	1	(	(	-LRB-
cord-343448-xhm97wy2	83	2	Liu	Liu	NNP
cord-343448-xhm97wy2	83	3	et	et	NNP
cord-343448-xhm97wy2	83	4	al	al	NNP
cord-343448-xhm97wy2	83	5	,	,	,
cord-343448-xhm97wy2	83	6	2020	2020	CD
cord-343448-xhm97wy2	83	7	)	)	-RRB-
cord-343448-xhm97wy2	83	8	.	.	.
cord-343448-xhm97wy2	84	1	"	"	''
cord-343448-xhm97wy2	85	1	Despite	despite	IN
cord-343448-xhm97wy2	85	2	two	two	CD
cord-343448-xhm97wy2	85	3	former	former	JJ
cord-343448-xhm97wy2	85	4	major	major	JJ
cord-343448-xhm97wy2	85	5	outbreaks	outbreak	NNS
cord-343448-xhm97wy2	85	6	of	of	IN
cord-343448-xhm97wy2	85	7	coronavirus	coronavirus	NN
cord-343448-xhm97wy2	85	8	infections	infection	NNS
cord-343448-xhm97wy2	85	9	causing	cause	VBG
cord-343448-xhm97wy2	85	10	the	the	DT
cord-343448-xhm97wy2	85	11	SARS	SARS	NNP
cord-343448-xhm97wy2	85	12	and	and	CC
cord-343448-xhm97wy2	85	13	MERS	MERS	NNP
cord-343448-xhm97wy2	85	14	respiratory	respiratory	JJ
cord-343448-xhm97wy2	85	15	illnesses	illness	NNS
cord-343448-xhm97wy2	85	16	,	,	,
cord-343448-xhm97wy2	85	17	the	the	DT
cord-343448-xhm97wy2	85	18	world	world	NN
cord-343448-xhm97wy2	85	19	remains	remain	VBZ
cord-343448-xhm97wy2	85	20	underprepared	underprepared	JJ
cord-343448-xhm97wy2	85	21	to	to	TO
cord-343448-xhm97wy2	85	22	effectively	effectively	RB
cord-343448-xhm97wy2	85	23	manage	manage	VB
cord-343448-xhm97wy2	85	24	the	the	DT
cord-343448-xhm97wy2	85	25	current	current	JJ
cord-343448-xhm97wy2	85	26	COVID-19	covid-19	JJ
cord-343448-xhm97wy2	85	27	outbreak	outbreak	NN
cord-343448-xhm97wy2	85	28	,	,	,
cord-343448-xhm97wy2	85	29	as	as	IN
cord-343448-xhm97wy2	85	30	evidenced	evidence	VBN
cord-343448-xhm97wy2	85	31	by	by	IN
cord-343448-xhm97wy2	85	32	the	the	DT
cord-343448-xhm97wy2	85	33	fact	fact	NN
cord-343448-xhm97wy2	85	34	that	that	IN
cord-343448-xhm97wy2	85	35	COVID-19	COVID-19	NNP
cord-343448-xhm97wy2	85	36	has	have	VBZ
cord-343448-xhm97wy2	85	37	resulted	result	VBN
cord-343448-xhm97wy2	85	38	in	in	IN
cord-343448-xhm97wy2	85	39	thousands	thousand	NNS
cord-343448-xhm97wy2	85	40	of	of	IN
cord-343448-xhm97wy2	85	41	deaths	death	NNS
cord-343448-xhm97wy2	85	42	worldwide	worldwide	RB
cord-343448-xhm97wy2	85	43	"	"	''
cord-343448-xhm97wy2	85	44	.	.	.
cord-343448-xhm97wy2	85	45	 	 	_SP
cord-343448-xhm97wy2	86	1	Another	another	DT
cord-343448-xhm97wy2	86	2	key	key	JJ
cord-343448-xhm97wy2	86	3	area	area	NN
cord-343448-xhm97wy2	86	4	,	,	,
cord-343448-xhm97wy2	86	5	where	where	WRB
cord-343448-xhm97wy2	86	6	RNAs	rna	NNS
cord-343448-xhm97wy2	86	7	are	be	VBP
cord-343448-xhm97wy2	86	8	expected	expect	VBN
cord-343448-xhm97wy2	86	9	to	to	TO
cord-343448-xhm97wy2	86	10	have	have	VB
cord-343448-xhm97wy2	86	11	a	a	DT
cord-343448-xhm97wy2	86	12	significant	significant	JJ
cord-343448-xhm97wy2	86	13	impact	impact	NN
cord-343448-xhm97wy2	86	14	,	,	,
cord-343448-xhm97wy2	86	15	is	be	VBZ
cord-343448-xhm97wy2	86	16	cancer	cancer	NN
cord-343448-xhm97wy2	86	17	therapy	therapy	NN
cord-343448-xhm97wy2	86	18	.	.	.
cord-343448-xhm97wy2	87	1	Here	here	RB
cord-343448-xhm97wy2	87	2	,	,	,
cord-343448-xhm97wy2	87	3	again	again	RB
cord-343448-xhm97wy2	87	4	,	,	,
cord-343448-xhm97wy2	87	5	mRNA	mrna	NN
cord-343448-xhm97wy2	87	6	vaccines	vaccine	NNS
cord-343448-xhm97wy2	87	7	are	be	VBP
cord-343448-xhm97wy2	87	8	bound	bind	VBN
cord-343448-xhm97wy2	87	9	to	to	TO
cord-343448-xhm97wy2	87	10	play	play	VB
cord-343448-xhm97wy2	87	11	a	a	DT
cord-343448-xhm97wy2	87	12	major	major	JJ
cord-343448-xhm97wy2	87	13	role	role	NN
cord-343448-xhm97wy2	87	14	in	in	IN
cord-343448-xhm97wy2	87	15	the	the	DT
cord-343448-xhm97wy2	87	16	future	future	NN
cord-343448-xhm97wy2	87	17	.	.	.
cord-343448-xhm97wy2	88	1	The	the	DT
cord-343448-xhm97wy2	88	2	idea	idea	NN
cord-343448-xhm97wy2	88	3	behind	behind	IN
cord-343448-xhm97wy2	88	4	many	many	JJ
cord-343448-xhm97wy2	88	5	ongoing	ongoing	JJ
cord-343448-xhm97wy2	88	6	clinical	clinical	JJ
cord-343448-xhm97wy2	88	7	trials	trial	NNS
cord-343448-xhm97wy2	88	8	is	be	VBZ
cord-343448-xhm97wy2	88	9	to	to	TO
cord-343448-xhm97wy2	88	10	elicit	elicit	VB
cord-343448-xhm97wy2	88	11	an	an	DT
cord-343448-xhm97wy2	88	12	antitumor	antitumor	JJ
cord-343448-xhm97wy2	88	13	immune	immune	JJ
cord-343448-xhm97wy2	88	14	response	response	NN
cord-343448-xhm97wy2	88	15	in	in	IN
cord-343448-xhm97wy2	88	16	patients	patient	NNS
cord-343448-xhm97wy2	88	17	by	by	IN
cord-343448-xhm97wy2	88	18	challenging	challenge	VBG
cord-343448-xhm97wy2	88	19	them	-PRON-	PRP
cord-343448-xhm97wy2	88	20	with	with	IN
cord-343448-xhm97wy2	88	21	mRNAs	mrnas	RB
cord-343448-xhm97wy2	88	22	encoding	encode	VBG
cord-343448-xhm97wy2	88	23	tumor	tumor	NN
cord-343448-xhm97wy2	88	24	-	-	HYPH
cord-343448-xhm97wy2	88	25	specific	specific	JJ
cord-343448-xhm97wy2	88	26	antigens	antigen	NNS
cord-343448-xhm97wy2	88	27	(	(	-LRB-
cord-343448-xhm97wy2	88	28	Pastor	Pastor	NNP
cord-343448-xhm97wy2	88	29	et	et	FW
cord-343448-xhm97wy2	88	30	al	al	NNP
cord-343448-xhm97wy2	88	31	,	,	,
cord-343448-xhm97wy2	88	32	2018	2018	CD
cord-343448-xhm97wy2	88	33	;	;	:
cord-343448-xhm97wy2	88	34	Pardi	Pardi	NNP
cord-343448-xhm97wy2	88	35	et	et	NNP
cord-343448-xhm97wy2	88	36	al	al	NNP
cord-343448-xhm97wy2	88	37	,	,	,
cord-343448-xhm97wy2	88	38	2020	2020	CD
cord-343448-xhm97wy2	88	39	)	)	-RRB-
cord-343448-xhm97wy2	88	40	.	.	.
cord-343448-xhm97wy2	89	1	These	these	DT
cord-343448-xhm97wy2	89	2	mRNAs	mrna	NNS
cord-343448-xhm97wy2	89	3	can	can	MD
cord-343448-xhm97wy2	89	4	be	be	VB
cord-343448-xhm97wy2	89	5	directly	directly	RB
cord-343448-xhm97wy2	89	6	injected	inject	VBN
cord-343448-xhm97wy2	89	7	as	as	IN
cord-343448-xhm97wy2	89	8	naked	naked	JJ
cord-343448-xhm97wy2	89	9	RNA	RNA	NNP
cord-343448-xhm97wy2	89	10	or	or	CC
cord-343448-xhm97wy2	89	11	loaded	load	VBN
cord-343448-xhm97wy2	89	12	into	into	IN
cord-343448-xhm97wy2	89	13	patient	patient	NN
cord-343448-xhm97wy2	89	14	-	-	HYPH
cord-343448-xhm97wy2	89	15	derived	derive	VBN
cord-343448-xhm97wy2	89	16	dendritic	dendritic	JJ
cord-343448-xhm97wy2	89	17	cells	cell	NNS
cord-343448-xhm97wy2	89	18	(	(	-LRB-
cord-343448-xhm97wy2	89	19	Fig	Fig	NNP
cord-343448-xhm97wy2	89	20	4	4	CD
cord-343448-xhm97wy2	89	21	)	)	-RRB-
cord-343448-xhm97wy2	89	22	.	.	.
cord-343448-xhm97wy2	90	1	The	the	DT
cord-343448-xhm97wy2	90	2	identification	identification	NN
cord-343448-xhm97wy2	90	3	of	of	IN
cord-343448-xhm97wy2	90	4	patient	patient	NN
cord-343448-xhm97wy2	90	5	-	-	HYPH
cord-343448-xhm97wy2	90	6	specific	specific	JJ
cord-343448-xhm97wy2	90	7	tumor	tumor	NN
cord-343448-xhm97wy2	90	8	antigens	antigen	NNS
cord-343448-xhm97wy2	90	9	can	can	MD
cord-343448-xhm97wy2	90	10	also	also	RB
cord-343448-xhm97wy2	90	11	allow	allow	VB
cord-343448-xhm97wy2	90	12	for	for	IN
cord-343448-xhm97wy2	90	13	personalized	personalized	JJ
cord-343448-xhm97wy2	90	14	mRNA	mrna	NN
cord-343448-xhm97wy2	90	15	cancer	cancer	NN
cord-343448-xhm97wy2	90	16	vaccines	vaccine	NNS
cord-343448-xhm97wy2	90	17	.	.	.
cord-343448-xhm97wy2	90	18	"	"	''
cord-343448-xhm97wy2	91	1	RNA	RNA	NNP
cord-343448-xhm97wy2	91	2	-	-	HYPH
cord-343448-xhm97wy2	91	3	based	base	VBN
cord-343448-xhm97wy2	91	4	cancer	cancer	NN
cord-343448-xhm97wy2	91	5	vaccines	vaccine	NNS
cord-343448-xhm97wy2	91	6	have	have	VBP
cord-343448-xhm97wy2	91	7	the	the	DT
cord-343448-xhm97wy2	91	8	advantage	advantage	NN
cord-343448-xhm97wy2	91	9	of	of	IN
cord-343448-xhm97wy2	91	10	providing	provide	VBG
cord-343448-xhm97wy2	91	11	transient	transient	JJ
cord-343448-xhm97wy2	91	12	expression	expression	NN
cord-343448-xhm97wy2	91	13	of	of	IN
cord-343448-xhm97wy2	91	14	tumor	tumor	NN
cord-343448-xhm97wy2	91	15	antigens	antigen	NNS
cord-343448-xhm97wy2	91	16	at	at	IN
cord-343448-xhm97wy2	91	17	high	high	JJ
cord-343448-xhm97wy2	91	18	levels	level	NNS
cord-343448-xhm97wy2	91	19	"	"	''
cord-343448-xhm97wy2	91	20	,	,	,
cord-343448-xhm97wy2	91	21	said	say	VBD
cord-343448-xhm97wy2	91	22	Kenneth	Kenneth	NNP
cord-343448-xhm97wy2	91	23	Lundstrom	Lundstrom	NNP
cord-343448-xhm97wy2	91	24	,	,	,
cord-343448-xhm97wy2	91	25	an	an	DT
cord-343448-xhm97wy2	91	26	expert	expert	NN
cord-343448-xhm97wy2	91	27	in	in	IN
cord-343448-xhm97wy2	91	28	cancer	cancer	NN
cord-343448-xhm97wy2	91	29	vaccines	vaccine	NNS
cord-343448-xhm97wy2	91	30	at	at	IN
cord-343448-xhm97wy2	91	31	PanTherapeutics	PanTherapeutics	NNP
cord-343448-xhm97wy2	91	32	,	,	,
cord-343448-xhm97wy2	91	33	Lutry	Lutry	NNP
cord-343448-xhm97wy2	91	34	,	,	,
cord-343448-xhm97wy2	91	35	Switzerland	Switzerland	NNP
cord-343448-xhm97wy2	91	36	.	.	.
cord-343448-xhm97wy2	92	1	"	"	''
cord-343448-xhm97wy2	93	1	Especially	especially	RB
cord-343448-xhm97wy2	93	2	,	,	,
cord-343448-xhm97wy2	93	3	application	application	NN
cord-343448-xhm97wy2	93	4	of	of	IN
cord-343448-xhm97wy2	93	5	RNA	RNA	NNP
cord-343448-xhm97wy2	93	6	replicons	replicon	NNS
cord-343448-xhm97wy2	93	7	from	from	IN
cord-343448-xhm97wy2	93	8	self	self	NN
cord-343448-xhm97wy2	93	9	-	-	HYPH
cord-343448-xhm97wy2	93	10	amplifying	amplify	VBG
cord-343448-xhm97wy2	93	11	RNA	RNA	NNP
cord-343448-xhm97wy2	93	12	viruses	virus	NNS
cord-343448-xhm97wy2	93	13	provides	provide	VBZ
cord-343448-xhm97wy2	93	14	the	the	DT
cord-343448-xhm97wy2	93	15	means	mean	NNS
cord-343448-xhm97wy2	93	16	for	for	IN
cord-343448-xhm97wy2	93	17	direct	direct	JJ
cord-343448-xhm97wy2	93	18	antigen	antigen	NN
cord-343448-xhm97wy2	93	19	mRNA	mrna	NN
cord-343448-xhm97wy2	93	20	amplification	amplification	NN
cord-343448-xhm97wy2	93	21	in	in	IN
cord-343448-xhm97wy2	93	22	the	the	DT
cord-343448-xhm97wy2	93	23	cytoplasm	cytoplasm	NN
cord-343448-xhm97wy2	93	24	leading	lead	VBG
cord-343448-xhm97wy2	93	25	to	to	IN
cord-343448-xhm97wy2	93	26	extremely	extremely	RB
cord-343448-xhm97wy2	93	27	high	high	JJ
cord-343448-xhm97wy2	93	28	levels	level	NNS
cord-343448-xhm97wy2	93	29	of	of	IN
cord-343448-xhm97wy2	93	30	antigen	antigen	NN
cord-343448-xhm97wy2	93	31	expression	expression	NN
cord-343448-xhm97wy2	93	32	for	for	IN
cord-343448-xhm97wy2	93	33	optimal	optimal	JJ
cord-343448-xhm97wy2	93	34	induction	induction	NN
cord-343448-xhm97wy2	93	35	of	of	IN
cord-343448-xhm97wy2	93	36	antibodies	antibody	NNS
cord-343448-xhm97wy2	93	37	"	"	''
cord-343448-xhm97wy2	93	38	.	.	.
cord-343448-xhm97wy2	94	1	Most	Most	JJS
cord-343448-xhm97wy2	94	2	such	such	JJ
cord-343448-xhm97wy2	94	3	therapeutics	therapeutic	NNS
cord-343448-xhm97wy2	94	4	are	be	VBP
cord-343448-xhm97wy2	94	5	still	still	RB
cord-343448-xhm97wy2	94	6	in	in	IN
cord-343448-xhm97wy2	94	7	Phase	phase	NN
cord-343448-xhm97wy2	94	8	1/2	1/2	CD
cord-343448-xhm97wy2	94	9	,	,	,
cord-343448-xhm97wy2	94	10	but	but	CC
cord-343448-xhm97wy2	94	11	there	there	EX
cord-343448-xhm97wy2	94	12	are	be	VBP
cord-343448-xhm97wy2	94	13	promising	promise	VBG
cord-343448-xhm97wy2	94	14	pre	pre	JJ
cord-343448-xhm97wy2	94	15	-	-	JJ
cord-343448-xhm97wy2	94	16	clinical	clinical	JJ
cord-343448-xhm97wy2	94	17	indications	indication	NNS
cord-343448-xhm97wy2	94	18	that	that	IN
cord-343448-xhm97wy2	94	19	this	this	DT
cord-343448-xhm97wy2	94	20	approach	approach	NN
cord-343448-xhm97wy2	94	21	might	may	MD
cord-343448-xhm97wy2	94	22	trigger	trigger	VB
cord-343448-xhm97wy2	94	23	an	an	DT
cord-343448-xhm97wy2	94	24	anti	anti	JJ
cord-343448-xhm97wy2	94	25	-	-	JJ
cord-343448-xhm97wy2	94	26	cancer	cancer	JJ
cord-343448-xhm97wy2	94	27	immune	immune	JJ
cord-343448-xhm97wy2	94	28	response	response	NN
cord-343448-xhm97wy2	94	29	.	.	.
cord-343448-xhm97wy2	95	1	CV9202	CV9202	NNP
cord-343448-xhm97wy2	95	2	,	,	,
cord-343448-xhm97wy2	95	3	for	for	IN
cord-343448-xhm97wy2	95	4	example	example	NN
cord-343448-xhm97wy2	95	5	,	,	,
cord-343448-xhm97wy2	95	6	is	be	VBZ
cord-343448-xhm97wy2	95	7	a	a	DT
cord-343448-xhm97wy2	95	8	mRNA	mrna	NN
cord-343448-xhm97wy2	95	9	encoding	encode	VBG
cord-343448-xhm97wy2	95	10	six	six	CD
cord-343448-xhm97wy2	95	11	antigens	antigen	NNS
cord-343448-xhm97wy2	95	12	usually	usually	RB
cord-343448-xhm97wy2	95	13	expressed	express	VBN
cord-343448-xhm97wy2	95	14	in	in	IN
cord-343448-xhm97wy2	95	15	non	non	JJ
cord-343448-xhm97wy2	95	16	-	-	JJ
cord-343448-xhm97wy2	95	17	small	small	JJ
cord-343448-xhm97wy2	95	18	-	-	HYPH
cord-343448-xhm97wy2	95	19	cell	cell	NN
cord-343448-xhm97wy2	95	20	lung	lung	NN
cord-343448-xhm97wy2	95	21	cancer	cancer	NN
cord-343448-xhm97wy2	95	22	(	(	-LRB-
cord-343448-xhm97wy2	95	23	NSCLC	NSCLC	NNP
cord-343448-xhm97wy2	95	24	)	)	-RRB-
cord-343448-xhm97wy2	95	25	,	,	,
cord-343448-xhm97wy2	95	26	developed	develop	VBN
cord-343448-xhm97wy2	95	27	by	by	IN
cord-343448-xhm97wy2	95	28	CureVac	CureVac	NNP
cord-343448-xhm97wy2	95	29	,	,	,
cord-343448-xhm97wy2	95	30	a	a	DT
cord-343448-xhm97wy2	95	31	biotech	biotech	NN
cord-343448-xhm97wy2	95	32	based	base	VBN
cord-343448-xhm97wy2	95	33	in	in	IN
cord-343448-xhm97wy2	95	34	Tübingen	Tübingen	NNP
cord-343448-xhm97wy2	95	35	,	,	,
cord-343448-xhm97wy2	95	36	Germany	Germany	NNP
cord-343448-xhm97wy2	95	37	(	(	-LRB-
cord-343448-xhm97wy2	95	38	https://www.curevac.com/	https://www.curevac.com/	NNP
cord-343448-xhm97wy2	95	39	)	)	-RRB-
cord-343448-xhm97wy2	95	40	,	,	,
cord-343448-xhm97wy2	95	41	in	in	IN
cord-343448-xhm97wy2	95	42	collaboration	collaboration	NN
cord-343448-xhm97wy2	95	43	with	with	IN
cord-343448-xhm97wy2	95	44	Boehringer	Boehringer	NNP
cord-343448-xhm97wy2	95	45	Ingelheim	Ingelheim	NNP
cord-343448-xhm97wy2	95	46	.	.	.
cord-343448-xhm97wy2	96	1	The	the	DT
cord-343448-xhm97wy2	96	2	mRNA	mrna	NN
cord-343448-xhm97wy2	96	3	has	have	VBZ
cord-343448-xhm97wy2	96	4	been	be	VBN
cord-343448-xhm97wy2	96	5	complexed	complexe	VBN
cord-343448-xhm97wy2	96	6	with	with	IN
cord-343448-xhm97wy2	96	7	the	the	DT
cord-343448-xhm97wy2	96	8	cationic	cationic	JJ
cord-343448-xhm97wy2	96	9	protein	protein	NN
cord-343448-xhm97wy2	96	10	protamine	protamine	NNP
cord-343448-xhm97wy2	96	11	to	to	TO
cord-343448-xhm97wy2	96	12	protect	protect	VB
cord-343448-xhm97wy2	96	13	it	-PRON-	PRP
cord-343448-xhm97wy2	96	14	from	from	IN
cord-343448-xhm97wy2	96	15	degradation	degradation	NN
cord-343448-xhm97wy2	96	16	and	and	CC
cord-343448-xhm97wy2	96	17	increase	increase	VB
cord-343448-xhm97wy2	96	18	immunogenicity	immunogenicity	NN
cord-343448-xhm97wy2	96	19	;	;	:
cord-343448-xhm97wy2	96	20	CV9202	CV9202	NNP
cord-343448-xhm97wy2	96	21	is	be	VBZ
cord-343448-xhm97wy2	96	22	currently	currently	RB
cord-343448-xhm97wy2	96	23	being	be	VBG
cord-343448-xhm97wy2	96	24	investigated	investigate	VBN
cord-343448-xhm97wy2	96	25	in	in	IN
cord-343448-xhm97wy2	96	26	a	a	DT
cord-343448-xhm97wy2	96	27	Phase	phase	NN
cord-343448-xhm97wy2	96	28	1/2	1/2	CD
cord-343448-xhm97wy2	96	29	trial	trial	NN
cord-343448-xhm97wy2	96	30	in	in	IN
cord-343448-xhm97wy2	96	31	metastatic	metastatic	JJ
cord-343448-xhm97wy2	96	32	NSCLC	NSCLC	NNP
cord-343448-xhm97wy2	96	33	patients	patient	NNS
cord-343448-xhm97wy2	96	34	(	(	-LRB-
cord-343448-xhm97wy2	96	35	https://c	https://c	NNP
cord-343448-xhm97wy2	96	36	linicaltrials.gov/ct2/show/NCT03164772?term	linicaltrials.gov/ct2/show/nct03164772?term	NN
cord-343448-xhm97wy2	96	37	=	=	NNP
cord-343448-xhm97wy2	96	38	NCT03164772&draw=2&rank=1	nct03164772&draw=2&rank=1	NN
cord-343448-xhm97wy2	96	39	)	)	-RRB-
cord-343448-xhm97wy2	96	40	.	.	.
cord-343448-xhm97wy2	97	1	Other	other	JJ
cord-343448-xhm97wy2	97	2	forms	form	NNS
cord-343448-xhm97wy2	97	3	of	of	IN
cord-343448-xhm97wy2	97	4	cancer	cancer	NN
cord-343448-xhm97wy2	97	5	are	be	VBP
cord-343448-xhm97wy2	97	6	also	also	RB
cord-343448-xhm97wy2	97	7	in	in	IN
cord-343448-xhm97wy2	97	8	the	the	DT
cord-343448-xhm97wy2	97	9	crosshairs	crosshair	NNS
cord-343448-xhm97wy2	97	10	.	.	.
cord-343448-xhm97wy2	97	11	"	"	''
cord-343448-xhm97wy2	98	1	Melanoma	melanoma	NN
cord-343448-xhm97wy2	98	2	seems	seem	VBZ
cord-343448-xhm97wy2	98	3	like	like	IN
cord-343448-xhm97wy2	98	4	a	a	DT
cord-343448-xhm97wy2	98	5	good	good	JJ
cord-343448-xhm97wy2	98	6	target	target	NN
cord-343448-xhm97wy2	98	7	,	,	,
cord-343448-xhm97wy2	98	8	which	which	WDT
cord-343448-xhm97wy2	98	9	has	have	VBZ
cord-343448-xhm97wy2	98	10	shown	show	VBN
cord-343448-xhm97wy2	98	11	promise	promise	NN
cord-343448-xhm97wy2	98	12	in	in	IN
cord-343448-xhm97wy2	98	13	clinical	clinical	JJ
cord-343448-xhm97wy2	98	14	trials	trial	NNS
cord-343448-xhm97wy2	98	15	"	"	''
cord-343448-xhm97wy2	98	16	,	,	,
cord-343448-xhm97wy2	98	17	said	say	VBD
cord-343448-xhm97wy2	98	18	Lundstrom	Lundstrom	NNP
cord-343448-xhm97wy2	98	19	.	.	.
cord-343448-xhm97wy2	99	1	"	"	''
cord-343448-xhm97wy2	100	1	Liposome	liposome	NN
cord-343448-xhm97wy2	100	2	and	and	CC
cord-343448-xhm97wy2	100	3	polymer	polymer	NN
cord-343448-xhm97wy2	100	4	encapsulation	encapsulation	NN
cord-343448-xhm97wy2	100	5	of	of	IN
cord-343448-xhm97wy2	100	6	RNA	RNA	NNP
cord-343448-xhm97wy2	100	7	can	can	MD
cord-343448-xhm97wy2	100	8	further	further	RB
cord-343448-xhm97wy2	100	9	provide	provide	VB
cord-343448-xhm97wy2	100	10	protection	protection	NN
cord-343448-xhm97wy2	100	11	against	against	IN
cord-343448-xhm97wy2	100	12	degradation	degradation	NN
cord-343448-xhm97wy2	100	13	and	and	CC
cord-343448-xhm97wy2	100	14	host	host	NN
cord-343448-xhm97wy2	100	15	immune	immune	JJ
cord-343448-xhm97wy2	100	16	recognition	recognition	NN
cord-343448-xhm97wy2	100	17	and	and	CC
cord-343448-xhm97wy2	100	18	can	can	MD
cord-343448-xhm97wy2	100	19	target	target	VB
cord-343448-xhm97wy2	100	20	and	and	CC
cord-343448-xhm97wy2	100	21	improve	improve	VB
cord-343448-xhm97wy2	100	22	RNA	RNA	NNP
cord-343448-xhm97wy2	100	23	delivery	delivery	NN
cord-343448-xhm97wy2	100	24	"	"	''
cord-343448-xhm97wy2	100	25	.	.	.
cord-343448-xhm97wy2	101	1	Needless	needless	JJ
cord-343448-xhm97wy2	101	2	to	to	TO
cord-343448-xhm97wy2	101	3	say	say	VB
cord-343448-xhm97wy2	101	4	,	,	,
cord-343448-xhm97wy2	101	5	success	success	NN
cord-343448-xhm97wy2	101	6	is	be	VBZ
cord-343448-xhm97wy2	101	7	not	not	RB
cord-343448-xhm97wy2	101	8	guaranteed	guarantee	VBN
cord-343448-xhm97wy2	101	9	.	.	.
cord-343448-xhm97wy2	102	1	In	in	IN
cord-343448-xhm97wy2	102	2	April	April	NNP
cord-343448-xhm97wy2	102	3	2018	2018	CD
cord-343448-xhm97wy2	102	4	,	,	,
cord-343448-xhm97wy2	102	5	Argos	Argos	NNP
cord-343448-xhm97wy2	102	6	Therapeutics	Therapeutics	NNP
cord-343448-xhm97wy2	102	7	discontinued	discontinue	VBD
cord-343448-xhm97wy2	102	8	a	a	DT
cord-343448-xhm97wy2	102	9	Phase	phase	NN
cord-343448-xhm97wy2	102	10	3	3	CD
cord-343448-xhm97wy2	102	11	trial	trial	NN
cord-343448-xhm97wy2	102	12	of	of	IN
cord-343448-xhm97wy2	102	13	its	-PRON-	PRP$
cord-343448-xhm97wy2	102	14	dendritic	dendritic	JJ
cord-343448-xhm97wy2	102	15	cells	cell	NNS
cord-343448-xhm97wy2	102	16	-	-	HYPH
cord-343448-xhm97wy2	102	17	loaded	load	VBN
cord-343448-xhm97wy2	102	18	mRNA	mrna	NN
cord-343448-xhm97wy2	102	19	vaccine	vaccine	NN
cord-343448-xhm97wy2	102	20	(	(	-LRB-
cord-343448-xhm97wy2	102	21	Rocapuldencel	Rocapuldencel	NNP
cord-343448-xhm97wy2	102	22	-	-	HYPH
cord-343448-xhm97wy2	102	23	T	T	NNP
cord-343448-xhm97wy2	102	24	)	)	-RRB-
cord-343448-xhm97wy2	102	25	against	against	IN
cord-343448-xhm97wy2	102	26	metastatic	metastatic	JJ
cord-343448-xhm97wy2	102	27	renal	renal	JJ
cord-343448-xhm97wy2	102	28	cell	cell	NN
cord-343448-xhm97wy2	102	29	carcinoma	carcinoma	NN
cord-343448-xhm97wy2	102	30	after	after	IN
cord-343448-xhm97wy2	102	31	disappointing	disappointing	JJ
cord-343448-xhm97wy2	102	32	results	result	NNS
cord-343448-xhm97wy2	102	33	(	(	-LRB-
cord-343448-xhm97wy2	102	34	https://www.targetedonc.com/	https://www.targetedonc.com/	CD
cord-343448-xhm97wy2	102	35	view	view	NN
cord-343448-xhm97wy2	102	36	/	/	SYM
cord-343448-xhm97wy2	102	37	phase	phase	NN
cord-343448-xhm97wy2	102	38	-	-	HYPH
cord-343448-xhm97wy2	102	39	iii	iii	NN
cord-343448-xhm97wy2	102	40	-	-	HYPH
cord-343448-xhm97wy2	102	41	rcc	rcc	NN
cord-343448-xhm97wy2	102	42	-	-	HYPH
cord-343448-xhm97wy2	102	43	trial	trial	NN
cord-343448-xhm97wy2	102	44	-	-	HYPH
cord-343448-xhm97wy2	102	45	stopped	stop	VBN
cord-343448-xhm97wy2	102	46	-	-	HYPH
cord-343448-xhm97wy2	102	47	after	after	IN
cord-343448-xhm97wy2	102	48	-	-	HYPH
cord-343448-xhm97wy2	102	49	rocapuld	rocapuld	NNP
cord-343448-xhm97wy2	102	50	encelt	encelt	NN
cord-343448-xhm97wy2	102	51	-	-	HYPH
cord-343448-xhm97wy2	102	52	falls	fall	VBZ
cord-343448-xhm97wy2	102	53	-	-	HYPH
cord-343448-xhm97wy2	102	54	short	short	NN
cord-343448-xhm97wy2	102	55	)	)	-RRB-
cord-343448-xhm97wy2	102	56	.	.	.
cord-343448-xhm97wy2	103	1	"	"	''
cord-343448-xhm97wy2	104	1	mRNA	mRNA	NNP
cord-343448-xhm97wy2	104	2	is	be	VBZ
cord-343448-xhm97wy2	104	3	the	the	DT
cord-343448-xhm97wy2	104	4	only	only	JJ
cord-343448-xhm97wy2	104	5	vaccine	vaccine	NN
cord-343448-xhm97wy2	104	6	format	format	NN
cord-343448-xhm97wy2	104	7	that	that	WDT
cord-343448-xhm97wy2	104	8	is	be	VBZ
cord-343448-xhm97wy2	104	9	highly	highly	RB
cord-343448-xhm97wy2	104	10	robust	robust	JJ
cord-343448-xhm97wy2	104	11	in	in	IN
cord-343448-xhm97wy2	104	12	terms	term	NNS
cord-343448-xhm97wy2	104	13	of	of	IN
cord-343448-xhm97wy2	104	14	productionany	productionany	JJ
cord-343448-xhm97wy2	104	15	sequence	sequence	NN
cord-343448-xhm97wy2	104	16	can	can	MD
cord-343448-xhm97wy2	104	17	be	be	VB
cord-343448-xhm97wy2	104	18	produced	produce	VBN
cord-343448-xhm97wy2	104	19	with	with	IN
cord-343448-xhm97wy2	104	20	the	the	DT
cord-343448-xhm97wy2	104	21	exact	exact	JJ
cord-343448-xhm97wy2	104	22	same	same	JJ
cord-343448-xhm97wy2	104	23	manufacturing	manufacturing	NN
cord-343448-xhm97wy2	104	24	processand	processand	NN
cord-343448-xhm97wy2	104	25	very	very	RB
cord-343448-xhm97wy2	104	26	reliable	reliable	JJ
cord-343448-xhm97wy2	104	27	in	in	IN
cord-343448-xhm97wy2	104	28	terms	term	NNS
cord-343448-xhm97wy2	104	29	of	of	IN
cord-343448-xhm97wy2	104	30	efficacy	efficacy	NN
cord-343448-xhm97wy2	104	31	,	,	,
cord-343448-xhm97wy2	104	32	as	as	IN
cord-343448-xhm97wy2	104	33	it	-PRON-	PRP
cord-343448-xhm97wy2	104	34	naturally	naturally	RB
cord-343448-xhm97wy2	104	35	induces	induce	VBZ
cord-343448-xhm97wy2	104	36	an	an	DT
cord-343448-xhm97wy2	104	37	innate	innate	JJ
cord-343448-xhm97wy2	104	38	immune	immune	JJ
cord-343448-xhm97wy2	104	39	response	response	NN
cord-343448-xhm97wy2	104	40	on	on	IN
cord-343448-xhm97wy2	104	41	its	-PRON-	PRP$
cord-343448-xhm97wy2	104	42	own	own	JJ
cord-343448-xhm97wy2	104	43	and	and	CC
cord-343448-xhm97wy2	104	44	at	at	IN
cord-343448-xhm97wy2	104	45	the	the	DT
cord-343448-xhm97wy2	104	46	same	same	JJ
cord-343448-xhm97wy2	104	47	time	time	NN
cord-343448-xhm97wy2	104	48	an	an	DT
cord-343448-xhm97wy2	104	49	adaptive	adaptive	JJ
cord-343448-xhm97wy2	104	50	immune	immune	JJ
cord-343448-xhm97wy2	104	51	response	response	NN
cord-343448-xhm97wy2	104	52	against	against	IN
cord-343448-xhm97wy2	104	53	the	the	DT
cord-343448-xhm97wy2	104	54	encoded	encode	VBN
cord-343448-xhm97wy2	104	55	protein	protein	NN
cord-343448-xhm97wy2	104	56	"	"	''
cord-343448-xhm97wy2	104	57	,	,	,
cord-343448-xhm97wy2	104	58	commented	comment	VBD
cord-343448-xhm97wy2	104	59	Steve	Steve	NNP
cord-343448-xhm97wy2	104	60	Pascolo	Pascolo	NNP
cord-343448-xhm97wy2	104	61	,	,	,
cord-343448-xhm97wy2	104	62	a	a	DT
cord-343448-xhm97wy2	104	63	molecular	molecular	JJ
cord-343448-xhm97wy2	104	64	biologist	biologist	NN
cord-343448-xhm97wy2	104	65	at	at	IN
cord-343448-xhm97wy2	104	66	the	the	DT
cord-343448-xhm97wy2	104	67	University	University	NNP
cord-343448-xhm97wy2	104	68	of	of	IN
cord-343448-xhm97wy2	104	69	Zurich	Zurich	NNP
cord-343448-xhm97wy2	104	70	,	,	,
cord-343448-xhm97wy2	104	71	Switzerland	Switzerland	NNP
cord-343448-xhm97wy2	104	72	.	.	.
cord-343448-xhm97wy2	104	73	"	"	''
cord-343448-xhm97wy2	105	1	Therefore	therefore	RB
cord-343448-xhm97wy2	105	2	,	,	,
cord-343448-xhm97wy2	105	3	its	-PRON-	PRP$
cord-343448-xhm97wy2	105	4	current	current	JJ
cord-343448-xhm97wy2	105	5	evaluation	evaluation	NN
cord-343448-xhm97wy2	105	6	in	in	IN
cord-343448-xhm97wy2	105	7	different	different	JJ
cord-343448-xhm97wy2	105	8	formats	format	NNS
cord-343448-xhm97wy2	105	9	such	such	JJ
cord-343448-xhm97wy2	105	10	as	as	IN
cord-343448-xhm97wy2	105	11	naked	naked	JJ
cord-343448-xhm97wy2	105	12	or	or	CC
cord-343448-xhm97wy2	105	13	formulated	formulate	VBN
cord-343448-xhm97wy2	105	14	in	in	IN
cord-343448-xhm97wy2	105	15	particles	particle	NNS
cord-343448-xhm97wy2	105	16	,	,	,
cord-343448-xhm97wy2	105	17	self	self	NN
cord-343448-xhm97wy2	105	18	-	-	HYPH
cord-343448-xhm97wy2	105	19	amplifying	amplify	VBG
cord-343448-xhm97wy2	105	20	or	or	CC
cord-343448-xhm97wy2	105	21	non	non	JJ
cord-343448-xhm97wy2	105	22	-	-	JJ
cord-343448-xhm97wy2	105	23	replicating	replicating	JJ
cord-343448-xhm97wy2	105	24	,	,	,
cord-343448-xhm97wy2	105	25	or	or	CC
cord-343448-xhm97wy2	105	26	different	different	JJ
cord-343448-xhm97wy2	105	27	site	site	NN
cord-343448-xhm97wy2	105	28	of	of	IN
cord-343448-xhm97wy2	105	29	injection	injection	NN
cord-343448-xhm97wy2	105	30	and	and	CC
cord-343448-xhm97wy2	105	31	design	design	NN
cord-343448-xhm97wy2	105	32	(	(	-LRB-
cord-343448-xhm97wy2	105	33	e.g.	e.g.	RB
cord-343448-xhm97wy2	105	34	,	,	,
cord-343448-xhm97wy2	105	35	coding	code	VBG
cord-343448-xhm97wy2	105	36	wild	wild	JJ
cord-343448-xhm97wy2	105	37	type	type	NN
cord-343448-xhm97wy2	105	38	proteins	protein	NNS
cord-343448-xhm97wy2	105	39	,	,	,
cord-343448-xhm97wy2	105	40	modified	modify	VBN
cord-343448-xhm97wy2	105	41	antigens	antigen	NNS
cord-343448-xhm97wy2	105	42	or	or	CC
cord-343448-xhm97wy2	105	43	epitopes	epitope	NNS
cord-343448-xhm97wy2	105	44	)	)	-RRB-
cord-343448-xhm97wy2	105	45	,	,	,
cord-343448-xhm97wy2	105	46	will	will	MD
cord-343448-xhm97wy2	105	47	with	with	IN
cord-343448-xhm97wy2	105	48	no	no	DT
cord-343448-xhm97wy2	105	49	doubt	doubt	RB
cord-343448-xhm97wy2	105	50	lead	lead	VB
cord-343448-xhm97wy2	105	51	to	to	IN
cord-343448-xhm97wy2	105	52	commercialization	commercialization	NN
cord-343448-xhm97wy2	105	53	of	of	IN
cord-343448-xhm97wy2	105	54	superlative	superlative	JJ
cord-343448-xhm97wy2	105	55	vaccines	vaccine	NNS
cord-343448-xhm97wy2	105	56	against	against	IN
cord-343448-xhm97wy2	105	57	cancer	cancer	NN
cord-343448-xhm97wy2	105	58	and	and	CC
cord-343448-xhm97wy2	105	59	infectious	infectious	JJ
cord-343448-xhm97wy2	105	60	diseases	disease	NNS
cord-343448-xhm97wy2	105	61	"	"	''
cord-343448-xhm97wy2	105	62	.	.	.
cord-343448-xhm97wy2	106	1	The	the	DT
cord-343448-xhm97wy2	106	2	scenario	scenario	NN
cord-343448-xhm97wy2	106	3	of	of	IN
cord-343448-xhm97wy2	106	4	cancer	cancer	NN
cord-343448-xhm97wy2	106	5	RNA	RNA	NNP
cord-343448-xhm97wy2	106	6	immunotherapeutics	immunotherapeutic	NNS
cord-343448-xhm97wy2	106	7	is	be	VBZ
cord-343448-xhm97wy2	106	8	rapidly	rapidly	RB
cord-343448-xhm97wy2	106	9	expanding	expand	VBG
cord-343448-xhm97wy2	106	10	,	,	,
cord-343448-xhm97wy2	106	11	with	with	IN
cord-343448-xhm97wy2	106	12	clinical	clinical	JJ
cord-343448-xhm97wy2	106	13	studies	study	NNS
cord-343448-xhm97wy2	106	14	of	of	IN
cord-343448-xhm97wy2	106	15	known	know	VBN
cord-343448-xhm97wy2	106	16	molecules	molecule	NNS
cord-343448-xhm97wy2	106	17	being	be	VBG
cord-343448-xhm97wy2	106	18	carried	carry	VBN
cord-343448-xhm97wy2	106	19	out	out	RP
cord-343448-xhm97wy2	106	20	and	and	CC
cord-343448-xhm97wy2	106	21	new	new	JJ
cord-343448-xhm97wy2	106	22	classes	class	NNS
cord-343448-xhm97wy2	106	23	of	of	IN
cord-343448-xhm97wy2	106	24	compounds	compound	NNS
cord-343448-xhm97wy2	106	25	emerging	emerge	VBG
cord-343448-xhm97wy2	106	26	.	.	.
cord-343448-xhm97wy2	107	1	The	the	DT
cord-343448-xhm97wy2	107	2	potential	potential	NN
cord-343448-xhm97wy2	107	3	of	of	IN
cord-343448-xhm97wy2	107	4	RNA	RNA	NNP
cord-343448-xhm97wy2	107	5	aptamers	aptamer	NNS
cord-343448-xhm97wy2	107	6	(	(	-LRB-
cord-343448-xhm97wy2	107	7	see	see	VB
cord-343448-xhm97wy2	107	8	above	above	RB
cord-343448-xhm97wy2	107	9	)	)	-RRB-
cord-343448-xhm97wy2	107	10	,	,	,
cord-343448-xhm97wy2	107	11	to	to	TO
cord-343448-xhm97wy2	107	12	target	target	VB
cord-343448-xhm97wy2	107	13	cancer	cancer	NN
cord-343448-xhm97wy2	107	14	-	-	HYPH
cord-343448-xhm97wy2	107	15	specific	specific	JJ
cord-343448-xhm97wy2	107	16	proteins	protein	NNS
cord-343448-xhm97wy2	107	17	,	,	,
cord-343448-xhm97wy2	107	18	has	have	VBZ
cord-343448-xhm97wy2	107	19	been	be	VBN
cord-343448-xhm97wy2	107	20	exploited	exploit	VBN
cord-343448-xhm97wy2	107	21	by	by	IN
cord-343448-xhm97wy2	107	22	NOXXON	NOXXON	NNP
cord-343448-xhm97wy2	107	23	Pharma	Pharma	NNP
cord-343448-xhm97wy2	107	24	(	(	-LRB-
cord-343448-xhm97wy2	107	25	Berlin	Berlin	NNP
cord-343448-xhm97wy2	107	26	,	,	,
cord-343448-xhm97wy2	107	27	Pharma	Pharma	NNP
cord-343448-xhm97wy2	107	28	)	)	-RRB-
cord-343448-xhm97wy2	107	29	.	.	.
cord-343448-xhm97wy2	108	1	Their	-PRON-	PRP$
cord-343448-xhm97wy2	108	2	NOX	NOX	NNP
cord-343448-xhm97wy2	108	3	-	-	HYPH
cord-343448-xhm97wy2	108	4	A12	A12	NNP
cord-343448-xhm97wy2	108	5	(	(	-LRB-
cord-343448-xhm97wy2	108	6	Olaptesed	olaptese	VBN
cord-343448-xhm97wy2	108	7	pegol	pegol	NN
cord-343448-xhm97wy2	108	8	)	)	-RRB-
cord-343448-xhm97wy2	108	9	,	,	,
cord-343448-xhm97wy2	108	10	a	a	DT
cord-343448-xhm97wy2	108	11	pegylated	pegylated	JJ
cord-343448-xhm97wy2	108	12	L	l	NN
cord-343448-xhm97wy2	108	13	-	-	HYPH
cord-343448-xhm97wy2	108	14	oligoribonucleotide	oligoribonucleotide	NNP
cord-343448-xhm97wy2	108	15	that	that	WDT
cord-343448-xhm97wy2	108	16	binds	bind	VBZ
cord-343448-xhm97wy2	108	17	and	and	CC
cord-343448-xhm97wy2	108	18	neutralizes	neutralize	VBZ
cord-343448-xhm97wy2	108	19	CXCL12	CXCL12	NNP
cord-343448-xhm97wy2	108	20	,	,	,
cord-343448-xhm97wy2	108	21	a	a	DT
cord-343448-xhm97wy2	108	22	chemokine	chemokine	NN
cord-343448-xhm97wy2	108	23	promoting	promote	VBG
cord-343448-xhm97wy2	108	24	tumor	tumor	NN
cord-343448-xhm97wy2	108	25	proliferation	proliferation	NN
cord-343448-xhm97wy2	108	26	,	,	,
cord-343448-xhm97wy2	108	27	yielded	yield	VBD
cord-343448-xhm97wy2	108	28	encouraging	encouraging	JJ
cord-343448-xhm97wy2	108	29	results	result	NNS
cord-343448-xhm97wy2	108	30	from	from	IN
cord-343448-xhm97wy2	108	31	a	a	DT
cord-343448-xhm97wy2	108	32	Phase	phase	NN
cord-343448-xhm97wy2	108	33	1/	1/	CD
cord-343448-xhm97wy2	108	34	2	2	CD
cord-343448-xhm97wy2	108	35	trial	trial	NN
cord-343448-xhm97wy2	108	36	in	in	IN
cord-343448-xhm97wy2	108	37	metastatic	metastatic	JJ
cord-343448-xhm97wy2	108	38	pancreatic	pancreatic	JJ
cord-343448-xhm97wy2	108	39	and	and	CC
cord-343448-xhm97wy2	108	40	colorectal	colorectal	JJ
cord-343448-xhm97wy2	108	41	cancer	cancer	NN
cord-343448-xhm97wy2	108	42	and	and	CC
cord-343448-xhm97wy2	108	43	is	be	VBZ
cord-343448-xhm97wy2	108	44	now	now	RB
cord-343448-xhm97wy2	108	45	being	be	VBG
cord-343448-xhm97wy2	108	46	tested	test	VBN
cord-343448-xhm97wy2	108	47	for	for	IN
cord-343448-xhm97wy2	108	48	other	other	JJ
cord-343448-xhm97wy2	108	49	oncological	oncological	JJ
cord-343448-xhm97wy2	108	50	applications	application	NNS
cord-343448-xhm97wy2	108	51	(	(	-LRB-
cord-343448-xhm97wy2	108	52	https://www	https://www	.
cord-343448-xhm97wy2	108	53	.	.	.
cord-343448-xhm97wy2	109	1	noxxon.com/downloads/pressrel/2020-04-24	noxxon.com/downloads/pressrel/2020-04-24	NNP
cord-343448-xhm97wy2	109	2	_	_	NNP
cord-343448-xhm97wy2	109	3	GBM_Cohort_1_DSMB_PR_EN.pdf	GBM_Cohort_1_DSMB_PR_EN.pdf	NNP
cord-343448-xhm97wy2	109	4	)	)	-RRB-
cord-343448-xhm97wy2	109	5	.	.	.
cord-343448-xhm97wy2	110	1	London	London	NNP
cord-343448-xhm97wy2	110	2	-	-	HYPH
cord-343448-xhm97wy2	110	3	based	base	VBN
cord-343448-xhm97wy2	110	4	MiNA	MiNA	NNP
cord-343448-xhm97wy2	110	5	therapeutics	therapeutic	NNS
cord-343448-xhm97wy2	110	6	,	,	,
cord-343448-xhm97wy2	110	7	a	a	DT
cord-343448-xhm97wy2	110	8	biotech	biotech	NN
cord-343448-xhm97wy2	110	9	graduated	graduate	VBD
cord-343448-xhm97wy2	110	10	from	from	IN
cord-343448-xhm97wy2	110	11	the	the	DT
cord-343448-xhm97wy2	110	12	Imperial	Imperial	NNP
cord-343448-xhm97wy2	110	13	College	College	NNP
cord-343448-xhm97wy2	110	14	's	's	POS
cord-343448-xhm97wy2	110	15	Translation	Translation	NNP
cord-343448-xhm97wy2	110	16	&	&	CC
cord-343448-xhm97wy2	110	17	Innovation	Innovation	NNP
cord-343448-xhm97wy2	110	18	Hub	Hub	NNP
cord-343448-xhm97wy2	110	19	,	,	,
cord-343448-xhm97wy2	110	20	is	be	VBZ
cord-343448-xhm97wy2	110	21	on	on	IN
cord-343448-xhm97wy2	110	22	a	a	DT
cord-343448-xhm97wy2	110	23	more	more	RBR
cord-343448-xhm97wy2	110	24	innovative	innovative	JJ
cord-343448-xhm97wy2	110	25	path	path	NN
cord-343448-xhm97wy2	110	26	.	.	.
cord-343448-xhm97wy2	111	1	The	the	DT
cord-343448-xhm97wy2	111	2	company	company	NN
cord-343448-xhm97wy2	111	3	's	's	POS
cord-343448-xhm97wy2	111	4	technology	technology	NN
cord-343448-xhm97wy2	111	5	hinges	hinge	VBZ
cord-343448-xhm97wy2	111	6	around	around	IN
cord-343448-xhm97wy2	111	7	small	small	JJ
cord-343448-xhm97wy2	111	8	activating	activate	VBG
cord-343448-xhm97wy2	111	9	RNAs	rna	NNS
cord-343448-xhm97wy2	111	10	(	(	-LRB-
cord-343448-xhm97wy2	111	11	saRNA	saRNA	''
cord-343448-xhm97wy2	111	12	)	)	-RRB-
cord-343448-xhm97wy2	111	13	,	,	,
cord-343448-xhm97wy2	111	14	short	short	JJ
cord-343448-xhm97wy2	111	15	oligonucleotides	oligonucleotide	NNS
cord-343448-xhm97wy2	111	16	similar	similar	JJ
cord-343448-xhm97wy2	111	17	in	in	IN
cord-343448-xhm97wy2	111	18	structure	structure	NN
cord-343448-xhm97wy2	111	19	to	to	IN
cord-343448-xhm97wy2	111	20	siRNAs	siRNAs	NNP
cord-343448-xhm97wy2	111	21	,	,	,
cord-343448-xhm97wy2	111	22	that	that	WDT
cord-343448-xhm97wy2	111	23	upregulate	upregulate	VBD
cord-343448-xhm97wy2	111	24	the	the	DT
cord-343448-xhm97wy2	111	25	expression	expression	NN
cord-343448-xhm97wy2	111	26	of	of	IN
cord-343448-xhm97wy2	111	27	their	-PRON-	PRP$
cord-343448-xhm97wy2	111	28	target	target	NN
cord-343448-xhm97wy2	111	29	gene	gene	NN
cord-343448-xhm97wy2	111	30	.	.	.
cord-343448-xhm97wy2	112	1	MiNA	MiNA	NNP
cord-343448-xhm97wy2	112	2	's	's	POS
cord-343448-xhm97wy2	112	3	lead	lead	NN
cord-343448-xhm97wy2	112	4	,	,	,
cord-343448-xhm97wy2	112	5	MTL	MTL	NNP
cord-343448-xhm97wy2	112	6	-	-	HYPH
cord-343448-xhm97wy2	112	7	CEBPA	CEBPA	NNP
cord-343448-xhm97wy2	112	8	,	,	,
cord-343448-xhm97wy2	112	9	promotes	promote	VBZ
cord-343448-xhm97wy2	112	10	the	the	DT
cord-343448-xhm97wy2	112	11	expression	expression	NN
cord-343448-xhm97wy2	112	12	of	of	IN
cord-343448-xhm97wy2	112	13	CEBPa	CEBPa	NNS
cord-343448-xhm97wy2	112	14	,	,	,
cord-343448-xhm97wy2	112	15	the	the	DT
cord-343448-xhm97wy2	112	16	product	product	NN
cord-343448-xhm97wy2	112	17	of	of	IN
cord-343448-xhm97wy2	112	18	a	a	DT
cord-343448-xhm97wy2	112	19	tumor	tumor	NN
cord-343448-xhm97wy2	112	20	suppressor	suppressor	NN
cord-343448-xhm97wy2	112	21	gene	gene	NN
cord-343448-xhm97wy2	112	22	that	that	WDT
cord-343448-xhm97wy2	112	23	is	be	VBZ
cord-343448-xhm97wy2	112	24	downregulated	downregulate	VBN
cord-343448-xhm97wy2	112	25	in	in	IN
cord-343448-xhm97wy2	112	26	various	various	JJ
cord-343448-xhm97wy2	112	27	cancers	cancer	NNS
cord-343448-xhm97wy2	112	28	.	.	.
cord-343448-xhm97wy2	113	1	This	this	DT
cord-343448-xhm97wy2	113	2	approach	approach	NN
cord-343448-xhm97wy2	113	3	is	be	VBZ
cord-343448-xhm97wy2	113	4	being	be	VBG
cord-343448-xhm97wy2	113	5	tested	test	VBN
cord-343448-xhm97wy2	113	6	in	in	IN
cord-343448-xhm97wy2	113	7	patients	patient	NNS
cord-343448-xhm97wy2	113	8	with	with	IN
cord-343448-xhm97wy2	113	9	hepatocarcinoma	hepatocarcinoma	NNP
cord-343448-xhm97wy2	113	10	and	and	CC
cord-343448-xhm97wy2	113	11	is	be	VBZ
cord-343448-xhm97wy2	113	12	now	now	RB
cord-343448-xhm97wy2	113	13	entering	enter	VBG
cord-343448-xhm97wy2	113	14	a	a	DT
cord-343448-xhm97wy2	113	15	Phase	phase	NN
cord-343448-xhm97wy2	113	16	1/1b	1/1b	CD
cord-343448-xhm97wy2	113	17	clinical	clinical	JJ
cord-343448-xhm97wy2	113	18	study	study	NN
cord-343448-xhm97wy2	113	19	as	as	IN
cord-343448-xhm97wy2	113	20	a	a	DT
cord-343448-xhm97wy2	113	21	treatment	treatment	NN
cord-343448-xhm97wy2	113	22	for	for	IN
cord-343448-xhm97wy2	113	23	advanced	advanced	JJ
cord-343448-xhm97wy2	113	24	solid	solid	JJ
cord-343448-xhm97wy2	113	25	tumors	tumor	NNS
cord-343448-xhm97wy2	113	26	.	.	.
cord-343448-xhm97wy2	114	1	"	"	''
cord-343448-xhm97wy2	115	1	MTL	MTL	NNP
cord-343448-xhm97wy2	115	2	-	-	HYPH
cord-343448-xhm97wy2	115	3	CEBPA	CEBPA	NNP
cord-343448-xhm97wy2	115	4	has	have	VBZ
cord-343448-xhm97wy2	115	5	shown	show	VBN
cord-343448-xhm97wy2	115	6	real	real	JJ
cord-343448-xhm97wy2	115	7	promise	promise	NN
cord-343448-xhm97wy2	115	8	as	as	IN
cord-343448-xhm97wy2	115	9	a	a	DT
cord-343448-xhm97wy2	115	10	combination	combination	NN
cord-343448-xhm97wy2	115	11	agent	agent	NN
cord-343448-xhm97wy2	115	12	in	in	IN
cord-343448-xhm97wy2	115	13	patients	patient	NNS
cord-343448-xhm97wy2	115	14	with	with	IN
cord-343448-xhm97wy2	115	15	liver	liver	NN
cord-343448-xhm97wy2	115	16	cancer	cancer	NN
cord-343448-xhm97wy2	115	17	and	and	CC
cord-343448-xhm97wy2	115	18	pre	pre	JJ
cord-343448-xhm97wy2	115	19	-	-	JJ
cord-343448-xhm97wy2	115	20	clinical	clinical	JJ
cord-343448-xhm97wy2	115	21	studies	study	NNS
cord-343448-xhm97wy2	115	22	suggest	suggest	VBP
cord-343448-xhm97wy2	115	23	that	that	IN
cord-343448-xhm97wy2	115	24	MTL	MTL	NNP
cord-343448-xhm97wy2	115	25	-	-	HYPH
cord-343448-xhm97wy2	115	26	CEBPA	CEBPA	NNP
cord-343448-xhm97wy2	115	27	may	may	MD
cord-343448-xhm97wy2	115	28	also	also	RB
cord-343448-xhm97wy2	115	29	be	be	VB
cord-343448-xhm97wy2	115	30	an	an	DT
cord-343448-xhm97wy2	115	31	attractive	attractive	JJ
cord-343448-xhm97wy2	115	32	agent	agent	NN
cord-343448-xhm97wy2	115	33	to	to	TO
cord-343448-xhm97wy2	115	34	enhance	enhance	VB
cord-343448-xhm97wy2	115	35	the	the	DT
cord-343448-xhm97wy2	115	36	benefits	benefit	NNS
cord-343448-xhm97wy2	115	37	of	of	IN
cord-343448-xhm97wy2	115	38	checkpoint	checkpoint	NN
cord-343448-xhm97wy2	115	39	inhibitors	inhibitor	NNS
cord-343448-xhm97wy2	115	40	"	"	''
cord-343448-xhm97wy2	115	41	,	,	,
cord-343448-xhm97wy2	115	42	commented	comment	VBD
cord-343448-xhm97wy2	115	43	Ruth	Ruth	NNP
cord-343448-xhm97wy2	115	44	Plummer	Plummer	NNP
cord-343448-xhm97wy2	115	45	,	,	,
cord-343448-xhm97wy2	115	46	Newcastle	Newcastle	NNP
cord-343448-xhm97wy2	115	47	University	University	NNP
cord-343448-xhm97wy2	115	48	Centre	Centre	NNP
cord-343448-xhm97wy2	115	49	for	for	IN
cord-343448-xhm97wy2	115	50	Cancer	Cancer	NNP
cord-343448-xhm97wy2	115	51	,	,	,
cord-343448-xhm97wy2	115	52	and	and	CC
cord-343448-xhm97wy2	115	53	leading	lead	VBG
cord-343448-xhm97wy2	115	54	scientist	scientist	NN
cord-343448-xhm97wy2	115	55	of	of	IN
cord-343448-xhm97wy2	115	56	the	the	DT
cord-343448-xhm97wy2	115	57	new	new	JJ
cord-343448-xhm97wy2	115	58	study	study	NN
cord-343448-xhm97wy2	115	59	(	(	-LRB-
cord-343448-xhm97wy2	115	60	https://minatx.com/wp-content/uploads/	https://minatx.com/wp-content/uploads/	NNP
cord-343448-xhm97wy2	115	61	2020/03/2020303_MiNA_Timepoint	2020/03/2020303_mina_timepoint	CD
cord-343448-xhm97wy2	115	62	-	-	:
cord-343448-xhm97wy2	115	63	Enrolm	Enrolm	NNP
cord-343448-xhm97wy2	115	64	ent_FINAL.pdf	ent_FINAL.pdf	NNPS
cord-343448-xhm97wy2	115	65	)	)	-RRB-
cord-343448-xhm97wy2	115	66	.	.	.
cord-343448-xhm97wy2	116	1	"	"	``
cord-343448-xhm97wy2	116	2	We	-PRON-	PRP
cord-343448-xhm97wy2	116	3	are	be	VBP
cord-343448-xhm97wy2	116	4	looking	look	VBG
cord-343448-xhm97wy2	116	5	forward	forward	RB
cord-343448-xhm97wy2	116	6	to	to	IN
cord-343448-xhm97wy2	116	7	evaluating	evaluate	VBG
cord-343448-xhm97wy2	116	8	this	this	DT
cord-343448-xhm97wy2	116	9	highly	highly	RB
cord-343448-xhm97wy2	116	10	innovative	innovative	JJ
cord-343448-xhm97wy2	116	11	combination	combination	NN
cord-343448-xhm97wy2	116	12	treatment	treatment	NN
cord-343448-xhm97wy2	116	13	in	in	IN
cord-343448-xhm97wy2	116	14	the	the	DT
cord-343448-xhm97wy2	116	15	upcoming	upcoming	JJ
cord-343448-xhm97wy2	116	16	Phase	Phase	NNP
cord-343448-xhm97wy2	116	17	I	-PRON-	PRP
cord-343448-xhm97wy2	116	18	trial	trial	NN
cord-343448-xhm97wy2	116	19	.	.	.
cord-343448-xhm97wy2	117	1	We	-PRON-	PRP
cord-343448-xhm97wy2	117	2	hope	hope	VBP
cord-343448-xhm97wy2	117	3	this	this	DT
cord-343448-xhm97wy2	117	4	combination	combination	NN
cord-343448-xhm97wy2	117	5	could	could	MD
cord-343448-xhm97wy2	117	6	become	become	VB
cord-343448-xhm97wy2	117	7	an	an	DT
cord-343448-xhm97wy2	117	8	effective	effective	JJ
cord-343448-xhm97wy2	117	9	new	new	JJ
cord-343448-xhm97wy2	117	10	treatment	treatment	NN
cord-343448-xhm97wy2	117	11	option	option	NN
cord-343448-xhm97wy2	117	12	for	for	IN
cord-343448-xhm97wy2	117	13	patients	patient	NNS
cord-343448-xhm97wy2	117	14	with	with	IN
cord-343448-xhm97wy2	117	15	solid	solid	JJ
cord-343448-xhm97wy2	117	16	tumour	tumour	NN
cord-343448-xhm97wy2	117	17	cancers	cancer	NNS
cord-343448-xhm97wy2	117	18	"	"	''
cord-343448-xhm97wy2	117	19	.	.	.
cord-343448-xhm97wy2	118	1	With	with	IN
cord-343448-xhm97wy2	118	2	the	the	DT
cord-343448-xhm97wy2	118	3	first	first	JJ
cord-343448-xhm97wy2	118	4	results	result	NNS
cord-343448-xhm97wy2	118	5	from	from	IN
cord-343448-xhm97wy2	118	6	anti	anti	JJ
cord-343448-xhm97wy2	118	7	-	-	JJ
cord-343448-xhm97wy2	118	8	SARS	SARS	NNP
cord-343448-xhm97wy2	118	9	-	-	HYPH
cord-343448-xhm97wy2	118	10	CoV-2	CoV-2	NNP
cord-343448-xhm97wy2	118	11	mRNA	mrna	NN
cord-343448-xhm97wy2	118	12	vaccines	vaccine	NNS
cord-343448-xhm97wy2	118	13	just	just	RB
cord-343448-xhm97wy2	118	14	weeks	week	NNS
cord-343448-xhm97wy2	118	15	way	way	NN
cord-343448-xhm97wy2	118	16	,	,	,
cord-343448-xhm97wy2	118	17	RNA	RNA	NNP
cord-343448-xhm97wy2	118	18	therapeutics	therapeutic	NNS
cord-343448-xhm97wy2	118	19	have	have	VBP
cord-343448-xhm97wy2	118	20	their	-PRON-	PRP$
cord-343448-xhm97wy2	118	21	once	once	RB
cord-343448-xhm97wy2	118	22	-	-	HYPH
cord-343448-xhm97wy2	118	23	in	in	IN
cord-343448-xhm97wy2	118	24	-	-	HYPH
cord-343448-xhm97wy2	118	25	a	a	DT
cord-343448-xhm97wy2	118	26	-	-	HYPH
cord-343448-xhm97wy2	118	27	lifetime	lifetime	NN
cord-343448-xhm97wy2	118	28	opportunity	opportunity	NN
cord-343448-xhm97wy2	118	29	to	to	TO
cord-343448-xhm97wy2	118	30	ultimately	ultimately	RB
cord-343448-xhm97wy2	118	31	prove	prove	VB
cord-343448-xhm97wy2	118	32	their	-PRON-	PRP$
cord-343448-xhm97wy2	118	33	value	value	NN
cord-343448-xhm97wy2	118	34	.	.	.
cord-343448-xhm97wy2	119	1	To	to	TO
cord-343448-xhm97wy2	119	2	expand	expand	VB
cord-343448-xhm97wy2	119	3	our	-PRON-	PRP$
cord-343448-xhm97wy2	119	4	possibilities	possibility	NNS
cord-343448-xhm97wy2	119	5	to	to	TO
cord-343448-xhm97wy2	119	6	treat	treat	VB
cord-343448-xhm97wy2	119	7	a	a	DT
cord-343448-xhm97wy2	119	8	variety	variety	NN
cord-343448-xhm97wy2	119	9	of	of	IN
cord-343448-xhm97wy2	119	10	serious	serious	JJ
cord-343448-xhm97wy2	119	11	diseases	disease	NNS
cord-343448-xhm97wy2	119	12	,	,	,
cord-343448-xhm97wy2	119	13	and	and	CC
cord-343448-xhm97wy2	119	14	to	to	TO
cord-343448-xhm97wy2	119	15	be	be	VB
cord-343448-xhm97wy2	119	16	ready	ready	JJ
cord-343448-xhm97wy2	119	17	,	,	,
cord-343448-xhm97wy2	119	18	for	for	IN
cord-343448-xhm97wy2	119	19	when	when	WRB
cord-343448-xhm97wy2	119	20	the	the	DT
cord-343448-xhm97wy2	119	21	next	next	JJ
cord-343448-xhm97wy2	119	22	virus	virus	NN
cord-343448-xhm97wy2	119	23	will	will	MD
cord-343448-xhm97wy2	119	24	spill	spill	VB
cord-343448-xhm97wy2	119	25	over	over	RP
cord-343448-xhm97wy2	119	26	into	into	IN
cord-343448-xhm97wy2	119	27	humans	human	NNS
cord-343448-xhm97wy2	119	28	.	.	.
cord-343448-xhm97wy2	120	1	Two	two	CD
cord-343448-xhm97wy2	120	2	categories	category	NNS
cord-343448-xhm97wy2	120	3	of	of	IN
cord-343448-xhm97wy2	120	4	mRNA	mrna	NN
cord-343448-xhm97wy2	120	5	constructs	construct	NNS
cord-343448-xhm97wy2	120	6	are	be	VBP
cord-343448-xhm97wy2	120	7	being	be	VBG
cord-343448-xhm97wy2	120	8	actively	actively	RB
cord-343448-xhm97wy2	120	9	evaluated	evaluate	VBN
cord-343448-xhm97wy2	120	10	.	.	.
cord-343448-xhm97wy2	121	1	Non	non	JJ
cord-343448-xhm97wy2	121	2	-	-	JJ
cord-343448-xhm97wy2	121	3	replicating	replicating	JJ
cord-343448-xhm97wy2	121	4	mRNA	mrna	NN
cord-343448-xhm97wy2	121	5	(	(	-LRB-
cord-343448-xhm97wy2	121	6	NRM	NRM	NNP
cord-343448-xhm97wy2	121	7	)	)	-RRB-
cord-343448-xhm97wy2	121	8	constructs	construct	NNS
cord-343448-xhm97wy2	121	9	encode	encode	VBP
cord-343448-xhm97wy2	121	10	the	the	DT
cord-343448-xhm97wy2	121	11	coding	code	VBG
cord-343448-xhm97wy2	121	12	sequence	sequence	NN
cord-343448-xhm97wy2	121	13	(	(	-LRB-
cord-343448-xhm97wy2	121	14	CDS	CDS	NNP
cord-343448-xhm97wy2	121	15	)	)	-RRB-
cord-343448-xhm97wy2	121	16	and	and	CC
cord-343448-xhm97wy2	121	17	are	be	VBP
cord-343448-xhm97wy2	121	18	flanked	flank	VBN
cord-343448-xhm97wy2	121	19	by	by	IN
cord-343448-xhm97wy2	121	20	5	5	CD
cord-343448-xhm97wy2	121	21	0	0	CD
cord-343448-xhm97wy2	121	22	and	and	CC
cord-343448-xhm97wy2	121	23	3	3	CD
cord-343448-xhm97wy2	121	24	0	0	CD
cord-343448-xhm97wy2	121	25	untranslated	untranslated	JJ
cord-343448-xhm97wy2	121	26	regions	region	NNS
cord-343448-xhm97wy2	121	27	(	(	-LRB-
cord-343448-xhm97wy2	121	28	UTRs	UTRs	NNP
cord-343448-xhm97wy2	121	29	)	)	-RRB-
cord-343448-xhm97wy2	121	30	,	,	,
cord-343448-xhm97wy2	121	31	a	a	DT
cord-343448-xhm97wy2	121	32	5	5	CD
cord-343448-xhm97wy2	121	33	0	0	CD
cord-343448-xhm97wy2	121	34	-cap	-cap	:
cord-343448-xhm97wy2	121	35	structure	structure	NN
cord-343448-xhm97wy2	121	36	and	and	CC
cord-343448-xhm97wy2	121	37	a	a	DT
cord-343448-xhm97wy2	121	38	3	3	CD
cord-343448-xhm97wy2	121	39	0	0	CD
cord-343448-xhm97wy2	121	40	-poly-(A	-poly-(A	,
cord-343448-xhm97wy2	121	41	)	)	-RRB-
cord-343448-xhm97wy2	121	42	tail	tail	NN
cord-343448-xhm97wy2	121	43	.	.	.
cord-343448-xhm97wy2	122	1	The	the	DT
cord-343448-xhm97wy2	122	2	self	self	NN
cord-343448-xhm97wy2	122	3	-	-	HYPH
cord-343448-xhm97wy2	122	4	amplifying	amplify	VBG
cord-343448-xhm97wy2	122	5	mRNA	mRNA	NNP
cord-343448-xhm97wy2	122	6	(	(	-LRB-
cord-343448-xhm97wy2	122	7	SAM	SAM	NNP
cord-343448-xhm97wy2	122	8	)	)	-RRB-
cord-343448-xhm97wy2	122	9	construct	construct	VBP
cord-343448-xhm97wy2	122	10	encodes	encode	VBZ
cord-343448-xhm97wy2	122	11	additional	additional	JJ
cord-343448-xhm97wy2	122	12	replicase	replicase	NN
cord-343448-xhm97wy2	122	13	components	component	NNS
cord-343448-xhm97wy2	122	14	able	able	JJ
cord-343448-xhm97wy2	122	15	to	to	TO
cord-343448-xhm97wy2	122	16	direct	direct	VB
cord-343448-xhm97wy2	122	17	intracellular	intracellular	JJ
cord-343448-xhm97wy2	122	18	mRNA	mrna	NN
cord-343448-xhm97wy2	122	19	amplification	amplification	NN
cord-343448-xhm97wy2	122	20	.	.	.
cord-343448-xhm97wy2	123	1	(	(	-LRB-
cord-343448-xhm97wy2	123	2	1	1	LS
cord-343448-xhm97wy2	123	3	)	)	-RRB-
cord-343448-xhm97wy2	123	4	NRM	NRM	NNP
cord-343448-xhm97wy2	123	5	and	and	CC
cord-343448-xhm97wy2	123	6	SAM	SAM	NNP
cord-343448-xhm97wy2	123	7	are	be	VBP
cord-343448-xhm97wy2	123	8	formulated	formulate	VBN
cord-343448-xhm97wy2	123	9	in	in	IN
cord-343448-xhm97wy2	123	10	this	this	DT
cord-343448-xhm97wy2	123	11	illustration	illustration	NN
cord-343448-xhm97wy2	123	12	in	in	IN
cord-343448-xhm97wy2	123	13	lipid	lipid	NN
cord-343448-xhm97wy2	123	14	nanoparticles	nanoparticle	NNS
cord-343448-xhm97wy2	123	15	(	(	-LRB-
cord-343448-xhm97wy2	123	16	LNPs	LNPs	NNP
cord-343448-xhm97wy2	123	17	)	)	-RRB-
cord-343448-xhm97wy2	123	18	that	that	WDT
cord-343448-xhm97wy2	123	19	encapsulate	encapsulate	VBP
cord-343448-xhm97wy2	123	20	the	the	DT
cord-343448-xhm97wy2	123	21	mRNA	mrna	NN
cord-343448-xhm97wy2	123	22	constructs	construct	NNS
cord-343448-xhm97wy2	123	23	to	to	TO
cord-343448-xhm97wy2	123	24	protect	protect	VB
cord-343448-xhm97wy2	123	25	them	-PRON-	PRP
cord-343448-xhm97wy2	123	26	from	from	IN
cord-343448-xhm97wy2	123	27	degradation	degradation	NN
cord-343448-xhm97wy2	123	28	and	and	CC
cord-343448-xhm97wy2	123	29	promote	promote	VB
cord-343448-xhm97wy2	123	30	cellular	cellular	JJ
cord-343448-xhm97wy2	123	31	uptake	uptake	NN
cord-343448-xhm97wy2	123	32	.	.	.
cord-343448-xhm97wy2	124	1	(	(	-LRB-
cord-343448-xhm97wy2	124	2	2	2	LS
cord-343448-xhm97wy2	124	3	)	)	-RRB-
cord-343448-xhm97wy2	124	4	Cellular	cellular	JJ
cord-343448-xhm97wy2	124	5	uptake	uptake	NN
cord-343448-xhm97wy2	124	6	of	of	IN
cord-343448-xhm97wy2	124	7	the	the	DT
cord-343448-xhm97wy2	124	8	mRNA	mrna	NN
cord-343448-xhm97wy2	124	9	with	with	IN
cord-343448-xhm97wy2	124	10	its	-PRON-	PRP$
cord-343448-xhm97wy2	124	11	delivery	delivery	NN
cord-343448-xhm97wy2	124	12	system	system	NN
cord-343448-xhm97wy2	124	13	typically	typically	RB
cord-343448-xhm97wy2	124	14	exploits	exploit	VBZ
cord-343448-xhm97wy2	124	15	membranederived	membranederived	NNP
cord-343448-xhm97wy2	124	16	endocytic	endocytic	JJ
cord-343448-xhm97wy2	124	17	pathways	pathway	NNS
cord-343448-xhm97wy2	124	18	.	.	.
cord-343448-xhm97wy2	125	1	(	(	-LRB-
cord-343448-xhm97wy2	125	2	3	3	LS
cord-343448-xhm97wy2	125	3	)	)	-RRB-
cord-343448-xhm97wy2	125	4	Endosomal	Endosomal	NNP
cord-343448-xhm97wy2	125	5	escape	escape	NN
cord-343448-xhm97wy2	125	6	allows	allow	VBZ
cord-343448-xhm97wy2	125	7	release	release	NN
cord-343448-xhm97wy2	125	8	of	of	IN
cord-343448-xhm97wy2	125	9	the	the	DT
cord-343448-xhm97wy2	125	10	mRNA	mrna	NN
cord-343448-xhm97wy2	125	11	into	into	IN
cord-343448-xhm97wy2	125	12	the	the	DT
cord-343448-xhm97wy2	125	13	cytosol	cytosol	NN
cord-343448-xhm97wy2	125	14	.	.	.
cord-343448-xhm97wy2	126	1	(	(	-LRB-
cord-343448-xhm97wy2	126	2	4	4	LS
cord-343448-xhm97wy2	126	3	)	)	-RRB-
cord-343448-xhm97wy2	126	4	Cytosol	Cytosol	NNP
cord-343448-xhm97wy2	126	5	-	-	HYPH
cord-343448-xhm97wy2	126	6	located	locate	VBN
cord-343448-xhm97wy2	126	7	NRM	NRM	NNP
cord-343448-xhm97wy2	126	8	constructs	construct	NNS
cord-343448-xhm97wy2	126	9	are	be	VBP
cord-343448-xhm97wy2	126	10	immediately	immediately	RB
cord-343448-xhm97wy2	126	11	translated	translate	VBN
cord-343448-xhm97wy2	126	12	by	by	IN
cord-343448-xhm97wy2	126	13	ribosomes	ribosome	NNS
cord-343448-xhm97wy2	126	14	to	to	TO
cord-343448-xhm97wy2	126	15	produce	produce	VB
cord-343448-xhm97wy2	126	16	the	the	DT
cord-343448-xhm97wy2	126	17	protein	protein	NN
cord-343448-xhm97wy2	126	18	of	of	IN
cord-343448-xhm97wy2	126	19	interest	interest	NN
cord-343448-xhm97wy2	126	20	,	,	,
cord-343448-xhm97wy2	126	21	which	which	WDT
cord-343448-xhm97wy2	126	22	undergoes	undergo	VBZ
cord-343448-xhm97wy2	126	23	subsequent	subsequent	JJ
cord-343448-xhm97wy2	126	24	post	post	JJ
cord-343448-xhm97wy2	126	25	-	-	JJ
cord-343448-xhm97wy2	126	26	translational	translational	JJ
cord-343448-xhm97wy2	126	27	modification	modification	NN
cord-343448-xhm97wy2	126	28	.	.	.
cord-343448-xhm97wy2	127	1	(	(	-LRB-
cord-343448-xhm97wy2	127	2	5	5	LS
cord-343448-xhm97wy2	127	3	)	)	-RRB-
cord-343448-xhm97wy2	127	4	SAM	SAM	NNP
cord-343448-xhm97wy2	127	5	constructs	construct	NNS
cord-343448-xhm97wy2	127	6	can	can	MD
cord-343448-xhm97wy2	127	7	also	also	RB
cord-343448-xhm97wy2	127	8	be	be	VB
cord-343448-xhm97wy2	127	9	immediately	immediately	RB
cord-343448-xhm97wy2	127	10	translated	translate	VBN
cord-343448-xhm97wy2	127	11	by	by	IN
cord-343448-xhm97wy2	127	12	ribosomes	ribosome	NNS
cord-343448-xhm97wy2	127	13	to	to	TO
cord-343448-xhm97wy2	127	14	produce	produce	VB
cord-343448-xhm97wy2	127	15	the	the	DT
cord-343448-xhm97wy2	127	16	replicase	replicase	NN
cord-343448-xhm97wy2	127	17	machinery	machinery	NN
cord-343448-xhm97wy2	127	18	necessary	necessary	JJ
cord-343448-xhm97wy2	127	19	for	for	IN
cord-343448-xhm97wy2	127	20	self	self	NN
cord-343448-xhm97wy2	127	21	-	-	HYPH
cord-343448-xhm97wy2	127	22	amplification	amplification	NN
cord-343448-xhm97wy2	127	23	of	of	IN
cord-343448-xhm97wy2	127	24	the	the	DT
cord-343448-xhm97wy2	127	25	mRNA	mrna	NN
cord-343448-xhm97wy2	127	26	.	.	.
cord-343448-xhm97wy2	128	1	(	(	-LRB-
cord-343448-xhm97wy2	128	2	6	6	CD
cord-343448-xhm97wy2	128	3	)	)	-RRB-
cord-343448-xhm97wy2	129	1	Self	self	NN
cord-343448-xhm97wy2	129	2	-	-	HYPH
cord-343448-xhm97wy2	129	3	amplified	amplify	VBN
cord-343448-xhm97wy2	129	4	mRNA	mrna	NN
cord-343448-xhm97wy2	129	5	constructs	construct	NNS
cord-343448-xhm97wy2	129	6	are	be	VBP
cord-343448-xhm97wy2	129	7	translated	translate	VBN
cord-343448-xhm97wy2	129	8	by	by	IN
cord-343448-xhm97wy2	129	9	ribosomes	ribosome	NNS
cord-343448-xhm97wy2	129	10	to	to	TO
cord-343448-xhm97wy2	129	11	produce	produce	VB
cord-343448-xhm97wy2	129	12	the	the	DT
cord-343448-xhm97wy2	129	13	protein	protein	NN
cord-343448-xhm97wy2	129	14	of	of	IN
cord-343448-xhm97wy2	129	15	interest	interest	NN
cord-343448-xhm97wy2	129	16	,	,	,
cord-343448-xhm97wy2	129	17	which	which	WDT
cord-343448-xhm97wy2	129	18	undergoes	undergo	VBZ
cord-343448-xhm97wy2	129	19	subsequent	subsequent	JJ
cord-343448-xhm97wy2	129	20	post	post	JJ
cord-343448-xhm97wy2	129	21	-	-	JJ
cord-343448-xhm97wy2	129	22	translational	translational	JJ
cord-343448-xhm97wy2	129	23	modification	modification	NN
cord-343448-xhm97wy2	129	24	.	.	.
cord-343448-xhm97wy2	130	1	(	(	-LRB-
cord-343448-xhm97wy2	130	2	7	7	CD
cord-343448-xhm97wy2	130	3	)	)	-RRB-
cord-343448-xhm97wy2	131	1	The	the	DT
cord-343448-xhm97wy2	131	2	expressed	express	VBN
cord-343448-xhm97wy2	131	3	proteins	protein	NNS
cord-343448-xhm97wy2	131	4	of	of	IN
cord-343448-xhm97wy2	131	5	interest	interest	NN
cord-343448-xhm97wy2	131	6	are	be	VBP
cord-343448-xhm97wy2	131	7	generated	generate	VBN
cord-343448-xhm97wy2	131	8	as	as	IN
cord-343448-xhm97wy2	131	9	secreted	secrete	VBN
cord-343448-xhm97wy2	131	10	,	,	,
cord-343448-xhm97wy2	131	11	trans	trans	NN
cord-343448-xhm97wy2	131	12	-	-	NN
cord-343448-xhm97wy2	131	13	membrane	membrane	NN
cord-343448-xhm97wy2	131	14	,	,	,
cord-343448-xhm97wy2	131	15	or	or	CC
cord-343448-xhm97wy2	131	16	intracellular	intracellular	JJ
cord-343448-xhm97wy2	131	17	protein	protein	NN
cord-343448-xhm97wy2	131	18	.	.	.
cord-343448-xhm97wy2	132	1	(	(	-LRB-
cord-343448-xhm97wy2	132	2	8)	8)	NNP
cord-343448-xhm97wy2	133	1	The	the	DT
cord-343448-xhm97wy2	133	2	innate	innate	JJ
cord-343448-xhm97wy2	133	3	and	and	CC
cord-343448-xhm97wy2	133	4	adaptive	adaptive	JJ
cord-343448-xhm97wy2	133	5	immune	immune	JJ
cord-343448-xhm97wy2	133	6	responses	response	NNS
cord-343448-xhm97wy2	133	7	detect	detect	VBP
cord-343448-xhm97wy2	133	8	the	the	DT
cord-343448-xhm97wy2	133	9	protein	protein	NN
cord-343448-xhm97wy2	133	10	of	of	IN
cord-343448-xhm97wy2	133	11	interest	interest	NN
cord-343448-xhm97wy2	133	12	.	.	.
cord-343448-xhm97wy2	134	1	Reproduced	reproduce	VBN
cord-343448-xhm97wy2	134	2	from	from	IN
cord-343448-xhm97wy2	134	3	(	(	-LRB-
cord-343448-xhm97wy2	134	4	Jackson	Jackson	NNP
cord-343448-xhm97wy2	134	5	et	et	NNP
cord-343448-xhm97wy2	134	6	al	al	NNP
cord-343448-xhm97wy2	134	7	,	,	,
cord-343448-xhm97wy2	134	8	2020	2020	CD
cord-343448-xhm97wy2	134	9	)	)	-RRB-
cord-343448-xhm97wy2	134	10	,	,	,
cord-343448-xhm97wy2	134	11	with	with	IN
cord-343448-xhm97wy2	134	12	permission	permission	NN
cord-343448-xhm97wy2	134	13	.	.	.
cord-343448-xhm97wy2	135	1	ª	ª	LS
cord-343448-xhm97wy2	135	2	2020	2020	CD
cord-343448-xhm97wy2	136	1	The	the	DT
cord-343448-xhm97wy2	136	2	Author	author	NN
cord-343448-xhm97wy2	136	3	EMBO	EMBO	NNP
cord-343448-xhm97wy2	136	4	reports	report	VBZ
cord-343448-xhm97wy2	136	5	21	21	CD
cord-343448-xhm97wy2	136	6	:	:	:
cord-343448-xhm97wy2	137	1	e51013	e51013	NNP
cord-343448-xhm97wy2	137	2	|	|	NNP
cord-343448-xhm97wy2	137	3	2020	2020	CD
cord-343448-xhm97wy2	138	1	The	the	DT
cord-343448-xhm97wy2	138	2	Onpattro	Onpattro	NNP
cord-343448-xhm97wy2	138	3	story	story	NN
cord-343448-xhm97wy2	138	4	and	and	CC
cord-343448-xhm97wy2	138	5	the	the	DT
cord-343448-xhm97wy2	138	6	clinical	clinical	JJ
cord-343448-xhm97wy2	138	7	translation	translation	NN
cord-343448-xhm97wy2	138	8	of	of	IN
cord-343448-xhm97wy2	138	9	nanomedicines	nanomedicines	NNP
cord-343448-xhm97wy2	138	10	containing	contain	VBG
cord-343448-xhm97wy2	138	11	nucleic	nucleic	JJ
cord-343448-xhm97wy2	138	12	acid	acid	NN
cord-343448-xhm97wy2	138	13	-	-	HYPH
cord-343448-xhm97wy2	138	14	based	base	VBN
cord-343448-xhm97wy2	138	15	drugs	drug	NNS
cord-343448-xhm97wy2	138	16	COVID-19	covid-19	VBP
cord-343448-xhm97wy2	138	17	needs	need	VBZ
cord-343448-xhm97wy2	138	18	a	a	DT
cord-343448-xhm97wy2	138	19	big	big	JJ
cord-343448-xhm97wy2	138	20	science	science	NN
cord-343448-xhm97wy2	138	21	approach	approach	NN
cord-343448-xhm97wy2	138	22	It	-PRON-	PRP
cord-343448-xhm97wy2	138	23	's	be	VBZ
cord-343448-xhm97wy2	138	24	time	time	NN
cord-343448-xhm97wy2	138	25	for	for	IN
cord-343448-xhm97wy2	138	26	scientists	scientist	NNS
cord-343448-xhm97wy2	138	27	to	to	TO
cord-343448-xhm97wy2	138	28	shout	shout	VB
cord-343448-xhm97wy2	138	29	about	about	IN
cord-343448-xhm97wy2	138	30	RNA	RNA	NNP
cord-343448-xhm97wy2	138	31	therapies	therapy	NNS
cord-343448-xhm97wy2	139	1	The	the	DT
cord-343448-xhm97wy2	139	2	promise	promise	NN
cord-343448-xhm97wy2	139	3	of	of	IN
cord-343448-xhm97wy2	139	4	mRNA	mRNA	NNP
cord-343448-xhm97wy2	139	5	vaccines	vaccine	NNS
cord-343448-xhm97wy2	139	6	:	:	:
cord-343448-xhm97wy2	139	7	a	a	DT
cord-343448-xhm97wy2	139	8	biotech	biotech	JJ
cord-343448-xhm97wy2	139	9	and	and	CC
cord-343448-xhm97wy2	139	10	industrial	industrial	JJ
cord-343448-xhm97wy2	139	11	perspective	perspective	NN
cord-343448-xhm97wy2	139	12	Multi	multi	JJ
cord-343448-xhm97wy2	139	13	-	-	JJ
cord-343448-xhm97wy2	139	14	antigenic	antigenic	JJ
cord-343448-xhm97wy2	139	15	human	human	JJ
cord-343448-xhm97wy2	139	16	cytomegalovirus	cytomegalovirus	NN
cord-343448-xhm97wy2	139	17	mRNA	mRNA	NNP
cord-343448-xhm97wy2	139	18	vaccines	vaccine	NNS
cord-343448-xhm97wy2	139	19	that	that	WDT
cord-343448-xhm97wy2	139	20	elicit	elicit	VBP
cord-343448-xhm97wy2	139	21	potent	potent	JJ
cord-343448-xhm97wy2	139	22	humoral	humoral	JJ
cord-343448-xhm97wy2	139	23	and	and	CC
cord-343448-xhm97wy2	139	24	cell	cell	NN
cord-343448-xhm97wy2	139	25	-	-	HYPH
cord-343448-xhm97wy2	139	26	mediated	mediate	VBN
cord-343448-xhm97wy2	139	27	immunity	immunity	NN
cord-343448-xhm97wy2	139	28	RNA	RNA	NNP
cord-343448-xhm97wy2	139	29	interference	interference	NN
cord-343448-xhm97wy2	139	30	therapies	therapy	NNS
cord-343448-xhm97wy2	139	31	could	could	MD
cord-343448-xhm97wy2	139	32	be	be	VB
cord-343448-xhm97wy2	139	33	on	on	IN
cord-343448-xhm97wy2	139	34	the	the	DT
cord-343448-xhm97wy2	139	35	cusp	cusp	NN
cord-343448-xhm97wy2	139	36	of	of	IN
cord-343448-xhm97wy2	139	37	success	success	NN
cord-343448-xhm97wy2	139	38	Research	research	NN
cord-343448-xhm97wy2	139	39	and	and	CC
cord-343448-xhm97wy2	139	40	development	development	NN
cord-343448-xhm97wy2	139	41	on	on	IN
cord-343448-xhm97wy2	139	42	therapeutic	therapeutic	JJ
cord-343448-xhm97wy2	139	43	agents	agent	NNS
cord-343448-xhm97wy2	139	44	and	and	CC
cord-343448-xhm97wy2	139	45	vaccines	vaccine	NNS
cord-343448-xhm97wy2	139	46	for	for	IN
cord-343448-xhm97wy2	139	47	COVID-19	covid-19	CD
cord-343448-xhm97wy2	139	48	and	and	CC
cord-343448-xhm97wy2	139	49	related	relate	VBN
cord-343448-xhm97wy2	139	50	human	human	JJ
cord-343448-xhm97wy2	139	51	coronavirus	coronavirus	NN
cord-343448-xhm97wy2	139	52	diseases	disease	NNS
cord-343448-xhm97wy2	140	1	Recent	recent	JJ
cord-343448-xhm97wy2	140	2	advances	advance	NNS
cord-343448-xhm97wy2	140	3	in	in	IN
cord-343448-xhm97wy2	140	4	mRNA	mRNA	NNP
cord-343448-xhm97wy2	140	5	vaccine	vaccine	NN
cord-343448-xhm97wy2	140	6	technology	technology	NN
cord-343448-xhm97wy2	141	1	An	an	DT
cord-343448-xhm97wy2	141	2	RNA	RNA	NNP
cord-343448-xhm97wy2	141	3	toolbox	toolbox	NN
cord-343448-xhm97wy2	141	4	for	for	IN
cord-343448-xhm97wy2	141	5	cancer	cancer	NN
cord-343448-xhm97wy2	141	6	immunotherapy	immunotherapy	NN
cord-343448-xhm97wy2	141	7	Current	current	JJ
cord-343448-xhm97wy2	141	8	trends	trend	NNS
cord-343448-xhm97wy2	141	9	in	in	IN
cord-343448-xhm97wy2	141	10	RNAbased	rnabased	JJ
cord-343448-xhm97wy2	141	11	therapeutic	therapeutic	JJ
cord-343448-xhm97wy2	141	12	development	development	NN
cord-343448-xhm97wy2	141	13	Figure	Figure	NNP
cord-343448-xhm97wy2	141	14	4	4	CD
cord-343448-xhm97wy2	141	15	.	.	.
cord-343448-xhm97wy2	142	1	Personalized	Personalized	NNP
cord-343448-xhm97wy2	142	2	mRNA	mrna	NN
cord-343448-xhm97wy2	142	3	-	-	HYPH
cord-343448-xhm97wy2	142	4	based	base	VBN
cord-343448-xhm97wy2	142	5	antitumor	antitumor	JJ
cord-343448-xhm97wy2	142	6	vaccines	vaccine	NNS
cord-343448-xhm97wy2	142	7	normal	normal	JJ
cord-343448-xhm97wy2	142	8	cells	cell	NNS
cord-343448-xhm97wy2	142	9	are	be	VBP
cord-343448-xhm97wy2	142	10	compared	compare	VBN
cord-343448-xhm97wy2	142	11	to	to	TO
cord-343448-xhm97wy2	142	12	identify	identify	VB
cord-343448-xhm97wy2	142	13	tumor	tumor	NN
cord-343448-xhm97wy2	142	14	-	-	HYPH
cord-343448-xhm97wy2	142	15	specific	specific	JJ
cord-343448-xhm97wy2	142	16	mutations	mutation	NNS
cord-343448-xhm97wy2	142	17	.	.	.
cord-343448-xhm97wy2	143	1	Point	point	NN
cord-343448-xhm97wy2	143	2	non	non	JJ
cord-343448-xhm97wy2	143	3	-	-	JJ
cord-343448-xhm97wy2	143	4	synonymous	synonymous	JJ
cord-343448-xhm97wy2	143	5	mutations	mutation	NNS
cord-343448-xhm97wy2	143	6	,	,	,
cord-343448-xhm97wy2	143	7	gene	gene	NN
cord-343448-xhm97wy2	143	8	deletions	deletion	NNS
cord-343448-xhm97wy2	143	9	,	,	,
cord-343448-xhm97wy2	143	10	or	or	CC
cord-343448-xhm97wy2	143	11	rearrangements	rearrangement	NNS
cord-343448-xhm97wy2	143	12	can	can	MD
cord-343448-xhm97wy2	143	13	give	give	VB
cord-343448-xhm97wy2	143	14	rise	rise	NN
cord-343448-xhm97wy2	143	15	to	to	IN
cord-343448-xhm97wy2	143	16	neoantigens	neoantigen	NNS
cord-343448-xhm97wy2	143	17	.	.	.
cord-343448-xhm97wy2	144	1	Several	several	JJ
cord-343448-xhm97wy2	144	2	bioinformatics	bioinformatics	NN
cord-343448-xhm97wy2	144	3	tools	tool	NNS
cord-343448-xhm97wy2	144	4	are	be	VBP
cord-343448-xhm97wy2	144	5	used	use	VBN
cord-343448-xhm97wy2	144	6	to	to	TO
cord-343448-xhm97wy2	144	7	predict	predict	VB
cord-343448-xhm97wy2	144	8	major	major	JJ
cord-343448-xhm97wy2	144	9	histocompatibility	histocompatibility	NN
cord-343448-xhm97wy2	144	10	complex	complex	NN
cord-343448-xhm97wy2	144	11	(	(	-LRB-
cord-343448-xhm97wy2	144	12	MHC	MHC	NNP
cord-343448-xhm97wy2	144	13	)	)	-RRB-
cord-343448-xhm97wy2	144	14	class	class	NN
cord-343448-xhm97wy2	144	15	I	i	NN
cord-343448-xhm97wy2	144	16	and	and	CC
cord-343448-xhm97wy2	144	17	class	class	NN
cord-343448-xhm97wy2	144	18	II	ii	NN
cord-343448-xhm97wy2	144	19	binding	binding	NN
cord-343448-xhm97wy2	144	20	(	(	-LRB-
cord-343448-xhm97wy2	144	21	necessary	necessary	JJ
cord-343448-xhm97wy2	144	22	for	for	IN
cord-343448-xhm97wy2	144	23	recognition	recognition	NN
cord-343448-xhm97wy2	144	24	by	by	IN
cord-343448-xhm97wy2	144	25	T	T	NNP
cord-343448-xhm97wy2	144	26	cells	cell	NNS
cord-343448-xhm97wy2	144	27	)	)	-RRB-
cord-343448-xhm97wy2	144	28	and	and	CC
cord-343448-xhm97wy2	144	29	RNA	RNA	NNP
cord-343448-xhm97wy2	144	30	expression	expression	NN
cord-343448-xhm97wy2	144	31	presence	presence	NN
cord-343448-xhm97wy2	144	32	of	of	IN
cord-343448-xhm97wy2	144	33	the	the	DT
cord-343448-xhm97wy2	144	34	mutated	mutate	VBN
cord-343448-xhm97wy2	144	35	antigen	antigen	NN
cord-343448-xhm97wy2	144	36	among	among	IN
cord-343448-xhm97wy2	144	37	tumor	tumor	NN
cord-343448-xhm97wy2	144	38	cells	cell	NNS
cord-343448-xhm97wy2	144	39	(	(	-LRB-
cord-343448-xhm97wy2	144	40	clonality	clonality	NN
cord-343448-xhm97wy2	144	41	)	)	-RRB-