id author title date pages extension mime words sentences flesch summary cache txt cord-023871-9vi0m378 Mizutani, Tetsuya Signaling Pathways of SARS-CoV In Vitro and In Vivo 2009-07-22 .txt text/plain 6788 375 50 AKT and JNK (Jun NH(2)-terminal kinase) signaling pathways are important to establish persistent infection of SARS-CoV in Vero E6 cells. SARS-CoV S protein expression induces release of interleukin-8 (IL-8) via ERK and p38 MAPK signaling pathways including activator protein 1 (AP-1) in A549 cells ). SARS-CoV infection induces apoptotic cell death in Vero E6 cells, via dephosphorylation of STAT3 by p38 MAPK activation, and inactivation of Akt, as previously described. Overexpression of SARS-CoV 3a protein in Vero E6 cells induces apoptosis, mediated through a caspase-8-dependent pathway or p38 MAPK Waye et al. Overexpression of severe acute respiratory syndrome coronavirus 3b protein induces both apoptosis and necrosis in Vero E6 cells The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells Microarray and real-time RT-PCR analyses of differential human gene expression patterns induced by severe acute respiratory syndrome (SARS) coronavirus infection of Vero cells ./cache/cord-023871-9vi0m378.txt ./txt/cord-023871-9vi0m378.txt