id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284322-synuzaxm	Borel, Nicole	Mixed infections with Chlamydia and porcine epidemic diarrhea virus - a new in vitro model of chlamydial persistence	2010-07-27		.txt	text/plain	5446	270	45	To confirm these initial observations, we established a cell culture model of mixed infections with Chlamydia and a cell culture-adapted porcine epidemic diarrhea virus (ca-PEDV) and hypothesized that this would result in the generation of persistent chlamydial forms. In contrast, dual infections with ca-PEDV and Chlamydia pecorum resulted in the exclusive production of aberrant inclusions containing between 2-50 ABs. Chlamydial inclusions in viral syncytia grew even larger than in non-viral infected Vero cells. The changes of chlamydial inclusion size by subsequent virus addition to Chlamydia abortus are different to those we observed in the Chlamydia pecorum dual infection experiments. TEM examinations of mixed infections (ca-PEDV and Chlamydia abortus or Chlamydia pecorum) revealed aberrant chlamydial inclusions containing fewer bacteria than typical inclusions and were located in viral syncytia or single cells without viral infection. Enlarged chlamydial inclusions were described in that study in the ca-PEDV co-infection model with Chlamydia abortus and Chlamydia pecorum but no further ultrastructural analysis has been subsequently performed.	./cache/cord-284322-synuzaxm.txt	./txt/cord-284322-synuzaxm.txt