id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312899-ot5pvtbl	Chen, F	In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds	2004-09-30		.txt	text/plain	3161	164	43	Commercial antiviral agents and pure chemical compounds extracted from traditional Chinese medicinal herbs were screened against 10 clinical isolates of SARS coronavirus by neutralisation tests with confirmation by plaque reduction assays. Interferon-beta-1a, leukocytic interferon-alpha, ribavirin, lopinavir, rimantadine, baicalin and glycyrrhizin showed antiviral activity. We report in this study on the in vitro antiviral susceptibility of 10 isolates of SARS coronavirus to commercially available antiviral agents and pure chemical compounds including baicalin, glycyrrhizin, and chlorogenic acid extracted from traditional Chinese herbs. Further testing by neutralization tests Table 3 Comparison of antiviral activity of 10 compounds against 10 strains of SARS-CoV in fRhK4 cell line, against the prototype strains (39849) with the other 9 isolates of SARS coronavirus against the active compounds confirmed detectable inhibitory activities for leukocytic interferon-alpha, interferon-beta-1a, ribavirin, lopinavir, rimantadine, and baicalin.	./cache/cord-312899-ot5pvtbl.txt	./txt/cord-312899-ot5pvtbl.txt