id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332276-gs80celr	Tan, Yee‐Joo	Regulation of cell death during infection by the severe acute respiratory syndrome coronavirus and other coronaviruses	2007-08-20		.txt	text/plain	5790	272	48	In two independent studies, it was demonstrated that the inhibition of apoptosis, either by caspase inhibitors or by overexpression of the Bcl-2 protein, did not affect SARS-CoV replication in Vero cells (Ren et al., 2005; Bordi et al., 2006) , suggesting that apoptosis does not play a role in facilitating viral release. The mechanisms for induction of apoptosis by these SARS-CoV proteins are unclear, although in some cases, it could be related to their abilities to interfere with cellular functions, such as blocking cell cycle progression, altering membrane permeability, activating signal transduction pathways, upregulating transcription factors and other regulatory genes (Table 1 ). (2007) The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) gene 7 products contribute to virus-induced apoptosis. Over-expression of 7a, a protein specifically encoded by the severe acute respiratory syndrome (SARS) -coronavirus, induces apoptosis via a caspase-dependent pathway	./cache/cord-332276-gs80celr.txt	./txt/cord-332276-gs80celr.txt