id sid tid token lemma pos cord-004825-cdvnqfjz 1 1 key key JJ cord-004825-cdvnqfjz 1 2 : : : cord-004825-cdvnqfjz 1 3 cord-004825-cdvnqfjz cord-004825-cdvnqfjz ADD cord-004825-cdvnqfjz 2 1 authors author NNS cord-004825-cdvnqfjz 2 2 : : : cord-004825-cdvnqfjz 2 3 Castilla Castilla NNP cord-004825-cdvnqfjz 2 4 , , , cord-004825-cdvnqfjz 2 5 V. V. NNP cord-004825-cdvnqfjz 2 6 ; ; : cord-004825-cdvnqfjz 2 7 Mersich Mersich NNP cord-004825-cdvnqfjz 2 8 , , , cord-004825-cdvnqfjz 2 9 S. S. NNP cord-004825-cdvnqfjz 2 10 E. E. NNP cord-004825-cdvnqfjz 2 11 ; ; : cord-004825-cdvnqfjz 2 12 Candurra Candurra NNP cord-004825-cdvnqfjz 2 13 , , , cord-004825-cdvnqfjz 2 14 N. N. NNP cord-004825-cdvnqfjz 2 15 A. a. NN cord-004825-cdvnqfjz 2 16 ; ; . cord-004825-cdvnqfjz 3 1 Damonte Damonte NNP cord-004825-cdvnqfjz 3 2 , , , cord-004825-cdvnqfjz 3 3 E. E. NNP cord-004825-cdvnqfjz 3 4 B. B. NNP cord-004825-cdvnqfjz 3 5 title title NN cord-004825-cdvnqfjz 3 6 : : : cord-004825-cdvnqfjz 4 1 The the DT cord-004825-cdvnqfjz 4 2 entry entry NN cord-004825-cdvnqfjz 4 3 of of IN cord-004825-cdvnqfjz 4 4 Junin Junin NNP cord-004825-cdvnqfjz 4 5 virus virus NN cord-004825-cdvnqfjz 4 6 into into IN cord-004825-cdvnqfjz 4 7 Vero Vero NNP cord-004825-cdvnqfjz 4 8 cells cell NNS cord-004825-cdvnqfjz 4 9 date date NN cord-004825-cdvnqfjz 4 10 : : : cord-004825-cdvnqfjz 4 11 1994 1994 CD cord-004825-cdvnqfjz 4 12 journal journal NN cord-004825-cdvnqfjz 4 13 : : : cord-004825-cdvnqfjz 5 1 Arch arch JJ cord-004825-cdvnqfjz 5 2 Virol Virol NNP cord-004825-cdvnqfjz 5 3 DOI doi NN cord-004825-cdvnqfjz 5 4 : : : cord-004825-cdvnqfjz 6 1 10.1007 10.1007 CD cord-004825-cdvnqfjz 6 2 / / SYM cord-004825-cdvnqfjz 6 3 bf01321064 bf01321064 NNP cord-004825-cdvnqfjz 6 4 sha sha NNP cord-004825-cdvnqfjz 7 1 : : : cord-004825-cdvnqfjz 7 2 ccca93c2e18c8ae3aecad0b824da37236419541d ccca93c2e18c8ae3aecad0b824da37236419541d NNP cord-004825-cdvnqfjz 7 3 doc_id doc_id NNPS cord-004825-cdvnqfjz 7 4 : : : cord-004825-cdvnqfjz 7 5 4825 4825 CD cord-004825-cdvnqfjz 7 6 cord_uid cord_uid NNS cord-004825-cdvnqfjz 7 7 : : : cord-004825-cdvnqfjz 7 8 cdvnqfjz cdvnqfjz NN cord-004825-cdvnqfjz 8 1 The the DT cord-004825-cdvnqfjz 8 2 entry entry NN cord-004825-cdvnqfjz 8 3 mechanism mechanism NN cord-004825-cdvnqfjz 8 4 of of IN cord-004825-cdvnqfjz 8 5 Junin Junin NNP cord-004825-cdvnqfjz 8 6 virus virus NN cord-004825-cdvnqfjz 8 7 ( ( -LRB- cord-004825-cdvnqfjz 8 8 JV JV NNP cord-004825-cdvnqfjz 8 9 ) ) -RRB- cord-004825-cdvnqfjz 8 10 into into IN cord-004825-cdvnqfjz 8 11 Vero Vero NNP cord-004825-cdvnqfjz 8 12 cells cell NNS cord-004825-cdvnqfjz 8 13 was be VBD cord-004825-cdvnqfjz 8 14 studied study VBN cord-004825-cdvnqfjz 8 15 analyzing analyze VBG cord-004825-cdvnqfjz 8 16 the the DT cord-004825-cdvnqfjz 8 17 effect effect NN cord-004825-cdvnqfjz 8 18 of of IN cord-004825-cdvnqfjz 8 19 lysosomotropic lysosomotropic JJ cord-004825-cdvnqfjz 8 20 compounds compound NNS cord-004825-cdvnqfjz 8 21 and and CC cord-004825-cdvnqfjz 8 22 acid acid NN cord-004825-cdvnqfjz 8 23 pH ph NN cord-004825-cdvnqfjz 8 24 on on IN cord-004825-cdvnqfjz 8 25 JV JV NNP cord-004825-cdvnqfjz 8 26 infection infection NN cord-004825-cdvnqfjz 8 27 . . . cord-004825-cdvnqfjz 9 1 Ammonium ammonium NN cord-004825-cdvnqfjz 9 2 chloride chloride NN cord-004825-cdvnqfjz 9 3 , , , cord-004825-cdvnqfjz 9 4 amantadine amantadine NNP cord-004825-cdvnqfjz 9 5 , , , cord-004825-cdvnqfjz 9 6 chlorpheniramine chlorpheniramine NN cord-004825-cdvnqfjz 9 7 and and CC cord-004825-cdvnqfjz 9 8 procaine procaine NN cord-004825-cdvnqfjz 9 9 inhibited inhibit VBD cord-004825-cdvnqfjz 9 10 JV JV NNP cord-004825-cdvnqfjz 9 11 production production NN cord-004825-cdvnqfjz 9 12 . . . cord-004825-cdvnqfjz 10 1 The the DT cord-004825-cdvnqfjz 10 2 action action NN cord-004825-cdvnqfjz 10 3 of of IN cord-004825-cdvnqfjz 10 4 ammonium ammonium NN cord-004825-cdvnqfjz 10 5 chloride chloride NN cord-004825-cdvnqfjz 10 6 was be VBD cord-004825-cdvnqfjz 10 7 exerted exert VBN cord-004825-cdvnqfjz 10 8 at at IN cord-004825-cdvnqfjz 10 9 early early JJ cord-004825-cdvnqfjz 10 10 times time NNS cord-004825-cdvnqfjz 10 11 of of IN cord-004825-cdvnqfjz 10 12 infection infection NN cord-004825-cdvnqfjz 10 13 . . . cord-004825-cdvnqfjz 11 1 Virus virus NN cord-004825-cdvnqfjz 11 2 internalization internalization NN cord-004825-cdvnqfjz 11 3 was be VBD cord-004825-cdvnqfjz 11 4 inhibited inhibit VBN cord-004825-cdvnqfjz 11 5 and and CC cord-004825-cdvnqfjz 11 6 viral viral JJ cord-004825-cdvnqfjz 11 7 protein protein NN cord-004825-cdvnqfjz 11 8 expression expression NN cord-004825-cdvnqfjz 11 9 was be VBD cord-004825-cdvnqfjz 11 10 not not RB cord-004825-cdvnqfjz 11 11 detected detect VBN cord-004825-cdvnqfjz 11 12 . . . cord-004825-cdvnqfjz 12 1 When when WRB cord-004825-cdvnqfjz 12 2 the the DT cord-004825-cdvnqfjz 12 3 extracellular extracellular JJ cord-004825-cdvnqfjz 12 4 medium medium NN cord-004825-cdvnqfjz 12 5 was be VBD cord-004825-cdvnqfjz 12 6 buffered buffer VBN cord-004825-cdvnqfjz 12 7 at at IN cord-004825-cdvnqfjz 12 8 low low JJ cord-004825-cdvnqfjz 12 9 pH ph NN cord-004825-cdvnqfjz 12 10 , , , cord-004825-cdvnqfjz 12 11 the the DT cord-004825-cdvnqfjz 12 12 ammonium ammonium NN cord-004825-cdvnqfjz 12 13 chloride chloride NN cord-004825-cdvnqfjz 12 14 induced induce VBN cord-004825-cdvnqfjz 12 15 block block NN cord-004825-cdvnqfjz 12 16 on on IN cord-004825-cdvnqfjz 12 17 JV JV NNP cord-004825-cdvnqfjz 12 18 infection infection NN cord-004825-cdvnqfjz 12 19 was be VBD cord-004825-cdvnqfjz 12 20 overcome overcome VBN cord-004825-cdvnqfjz 12 21 . . . cord-004825-cdvnqfjz 13 1 Furthermore furthermore RB cord-004825-cdvnqfjz 13 2 , , , cord-004825-cdvnqfjz 13 3 JV JV NNP cord-004825-cdvnqfjz 13 4 was be VBD cord-004825-cdvnqfjz 13 5 able able JJ cord-004825-cdvnqfjz 13 6 to to TO cord-004825-cdvnqfjz 13 7 induce induce VB cord-004825-cdvnqfjz 13 8 fusion fusion NN cord-004825-cdvnqfjz 13 9 of of IN cord-004825-cdvnqfjz 13 10 infected infected JJ cord-004825-cdvnqfjz 13 11 cells cell NNS cord-004825-cdvnqfjz 13 12 at at IN cord-004825-cdvnqfjz 13 13 pH pH NNP cord-004825-cdvnqfjz 13 14 5.5 5.5 CD cord-004825-cdvnqfjz 13 15 leading lead VBG cord-004825-cdvnqfjz 13 16 to to IN cord-004825-cdvnqfjz 13 17 polykaryoctye polykaryoctye NNP cord-004825-cdvnqfjz 13 18 formation formation NN cord-004825-cdvnqfjz 13 19 . . . cord-004825-cdvnqfjz 14 1 Taken take VBN cord-004825-cdvnqfjz 14 2 together together RB cord-004825-cdvnqfjz 14 3 , , , cord-004825-cdvnqfjz 14 4 these these DT cord-004825-cdvnqfjz 14 5 results result NNS cord-004825-cdvnqfjz 14 6 demonstrate demonstrate VBP cord-004825-cdvnqfjz 14 7 that that IN cord-004825-cdvnqfjz 14 8 JV JV NNP cord-004825-cdvnqfjz 14 9 entry entry NN cord-004825-cdvnqfjz 14 10 occurs occur VBZ cord-004825-cdvnqfjz 14 11 through through IN cord-004825-cdvnqfjz 14 12 an an DT cord-004825-cdvnqfjz 14 13 endocytic endocytic JJ cord-004825-cdvnqfjz 14 14 mechanism mechanism NN cord-004825-cdvnqfjz 14 15 requiring require VBG cord-004825-cdvnqfjz 14 16 a a DT cord-004825-cdvnqfjz 14 17 low low JJ cord-004825-cdvnqfjz 14 18 pH ph NN cord-004825-cdvnqfjz 14 19 dependent dependent JJ cord-004825-cdvnqfjz 14 20 membrane membrane NN cord-004825-cdvnqfjz 14 21 fusion fusion NN cord-004825-cdvnqfjz 14 22 . . . cord-004825-cdvnqfjz 15 1 Junin junin NN cord-004825-cdvnqfjz 15 2 virus virus NN cord-004825-cdvnqfjz 15 3 ( ( -LRB- cord-004825-cdvnqfjz 15 4 JV JV NNP cord-004825-cdvnqfjz 15 5 ) ) -RRB- cord-004825-cdvnqfjz 15 6 is be VBZ cord-004825-cdvnqfjz 15 7 a a DT cord-004825-cdvnqfjz 15 8 member member NN cord-004825-cdvnqfjz 15 9 of of IN cord-004825-cdvnqfjz 15 10 the the DT cord-004825-cdvnqfjz 15 11 Arenaviridae Arenaviridae NNP cord-004825-cdvnqfjz 15 12 family family NN cord-004825-cdvnqfjz 15 13 of of IN cord-004825-cdvnqfjz 15 14 enveloped envelop VBN cord-004825-cdvnqfjz 15 15 RNA RNA NNP cord-004825-cdvnqfjz 15 16 viruses virus NNS cord-004825-cdvnqfjz 15 17 . . . cord-004825-cdvnqfjz 16 1 Virions virion NNS cord-004825-cdvnqfjz 16 2 contain contain VBP cord-004825-cdvnqfjz 16 3 a a DT cord-004825-cdvnqfjz 16 4 genome genome NN cord-004825-cdvnqfjz 16 5 composed compose VBN cord-004825-cdvnqfjz 16 6 of of IN cord-004825-cdvnqfjz 16 7 two two CD cord-004825-cdvnqfjz 16 8 segments segment NNS cord-004825-cdvnqfjz 16 9 of of IN cord-004825-cdvnqfjz 16 10 single single RB cord-004825-cdvnqfjz 16 11 - - HYPH cord-004825-cdvnqfjz 16 12 stranded strand VBN cord-004825-cdvnqfjz 16 13 RNA RNA NNP cord-004825-cdvnqfjz 16 14 and and CC cord-004825-cdvnqfjz 16 15 two two CD cord-004825-cdvnqfjz 16 16 major major JJ cord-004825-cdvnqfjz 16 17 structural structural JJ cord-004825-cdvnqfjz 16 18 proteins protein NNS cord-004825-cdvnqfjz 16 19 , , , cord-004825-cdvnqfjz 16 20 the the DT cord-004825-cdvnqfjz 16 21 nucleocapsid nucleocapsid NNP cord-004825-cdvnqfjz 16 22 protein protein NNP cord-004825-cdvnqfjz 16 23 ( ( -LRB- cord-004825-cdvnqfjz 16 24 NP NP NNP cord-004825-cdvnqfjz 16 25 , , , cord-004825-cdvnqfjz 16 26 MW MW NNP cord-004825-cdvnqfjz 16 27 60 60 CD cord-004825-cdvnqfjz 16 28 - - SYM cord-004825-cdvnqfjz 16 29 64 64 CD cord-004825-cdvnqfjz 16 30 kDa kDa NNS cord-004825-cdvnqfjz 16 31 ) ) -RRB- cord-004825-cdvnqfjz 16 32 and and CC cord-004825-cdvnqfjz 16 33 an an DT cord-004825-cdvnqfjz 16 34 external external JJ cord-004825-cdvnqfjz 16 35 glycoprotein glycoprotein NN cord-004825-cdvnqfjz 16 36 ( ( -LRB- cord-004825-cdvnqfjz 16 37 GP38 GP38 NNP cord-004825-cdvnqfjz 16 38 , , , cord-004825-cdvnqfjz 16 39 MW MW NNP cord-004825-cdvnqfjz 16 40 38 38 CD cord-004825-cdvnqfjz 16 41 kDa kDa NNPS cord-004825-cdvnqfjz 16 42 ) ) -RRB- cord-004825-cdvnqfjz 16 43 [ [ -LRB- cord-004825-cdvnqfjz 16 44 20 20 CD cord-004825-cdvnqfjz 16 45 ] ] -RRB- cord-004825-cdvnqfjz 16 46 . . . cord-004825-cdvnqfjz 17 1 Other other JJ cord-004825-cdvnqfjz 17 2 minor minor JJ cord-004825-cdvnqfjz 17 3 proteins protein NNS cord-004825-cdvnqfjz 17 4 have have VBP cord-004825-cdvnqfjz 17 5 also also RB cord-004825-cdvnqfjz 17 6 been be VBN cord-004825-cdvnqfjz 17 7 described describe VBN cord-004825-cdvnqfjz 17 8 in in IN cord-004825-cdvnqfjz 17 9 purified purify VBN cord-004825-cdvnqfjz 17 10 virions virion NNS cord-004825-cdvnqfjz 17 11 or or CC cord-004825-cdvnqfjz 17 12 in in IN cord-004825-cdvnqfjz 17 13 infected infected JJ cord-004825-cdvnqfjz 17 14 cells cell NNS cord-004825-cdvnqfjz 17 15 [ [ -LRB- cord-004825-cdvnqfjz 17 16 5 5 CD cord-004825-cdvnqfjz 17 17 , , , cord-004825-cdvnqfjz 17 18 6 6 CD cord-004825-cdvnqfjz 17 19 , , , cord-004825-cdvnqfjz 17 20 10 10 CD cord-004825-cdvnqfjz 17 21 ] ] -RRB- cord-004825-cdvnqfjz 17 22 . . . cord-004825-cdvnqfjz 18 1 The the DT cord-004825-cdvnqfjz 18 2 main main JJ cord-004825-cdvnqfjz 18 3 biological biological JJ cord-004825-cdvnqfjz 18 4 properties property NNS cord-004825-cdvnqfjz 18 5 of of IN cord-004825-cdvnqfjz 18 6 JV JV NNP cord-004825-cdvnqfjz 18 7 are be VBP cord-004825-cdvnqfjz 18 8 its -PRON- PRP$ cord-004825-cdvnqfjz 18 9 ability ability NN cord-004825-cdvnqfjz 18 10 to to TO cord-004825-cdvnqfjz 18 11 establish establish VB cord-004825-cdvnqfjz 18 12 persistently persistently RB cord-004825-cdvnqfjz 18 13 infected infect VBN cord-004825-cdvnqfjz 18 14 cultures culture NNS cord-004825-cdvnqfjz 18 15 in in IN cord-004825-cdvnqfjz 18 16 - - HYPH cord-004825-cdvnqfjz 18 17 vitro vitro FW cord-004825-cdvnqfjz 18 18 and and CC cord-004825-cdvnqfjz 18 19 to to TO cord-004825-cdvnqfjz 18 20 produce produce VB cord-004825-cdvnqfjz 18 21 chronic chronic JJ cord-004825-cdvnqfjz 18 22 infections infection NNS cord-004825-cdvnqfjz 18 23 in in IN cord-004825-cdvnqfjz 18 24 the the DT cord-004825-cdvnqfjz 18 25 field field NN cord-004825-cdvnqfjz 18 26 mouse mouse NN cord-004825-cdvnqfjz 18 27 Calomys Calomys NNP cord-004825-cdvnqfjz 18 28 musculinus musculinus NNP cord-004825-cdvnqfjz 18 29 [ [ -LRB- cord-004825-cdvnqfjz 18 30 27 27 CD cord-004825-cdvnqfjz 18 31 ] ] -RRB- cord-004825-cdvnqfjz 18 32 . . . cord-004825-cdvnqfjz 19 1 In in IN cord-004825-cdvnqfjz 19 2 humans human NNS cord-004825-cdvnqfjz 19 3 , , , cord-004825-cdvnqfjz 19 4 JV JV NNP cord-004825-cdvnqfjz 19 5 induces induce VBZ cord-004825-cdvnqfjz 19 6 Argentine argentine JJ cord-004825-cdvnqfjz 19 7 haemorrhagic haemorrhagic JJ cord-004825-cdvnqfjz 19 8 fever fever NN cord-004825-cdvnqfjz 19 9 , , , cord-004825-cdvnqfjz 19 10 an an DT cord-004825-cdvnqfjz 19 11 endemoepidemic endemoepidemic JJ cord-004825-cdvnqfjz 19 12 disease disease NN cord-004825-cdvnqfjz 19 13 with with IN cord-004825-cdvnqfjz 19 14 hematologic hematologic JJ cord-004825-cdvnqfjz 19 15 and and CC cord-004825-cdvnqfjz 19 16 neurologic neurologic JJ cord-004825-cdvnqfjz 19 17 signs sign NNS cord-004825-cdvnqfjz 19 18 , , , cord-004825-cdvnqfjz 19 19 which which WDT cord-004825-cdvnqfjz 19 20 mainly mainly RB cord-004825-cdvnqfjz 19 21 affects affect VBZ cord-004825-cdvnqfjz 19 22 male male JJ cord-004825-cdvnqfjz 19 23 rural rural JJ cord-004825-cdvnqfjz 19 24 workers worker NNS cord-004825-cdvnqfjz 19 25 [ [ -LRB- cord-004825-cdvnqfjz 19 26 -27 -27 NN cord-004825-cdvnqfjz 19 27 ] ] -RRB- cord-004825-cdvnqfjz 19 28 . . . cord-004825-cdvnqfjz 20 1 Although although IN cord-004825-cdvnqfjz 20 2 some some DT cord-004825-cdvnqfjz 20 3 features feature NNS cord-004825-cdvnqfjz 20 4 of of IN cord-004825-cdvnqfjz 20 5 arenavirus arenavirus NNP cord-004825-cdvnqfjz 20 6 replication replication NN cord-004825-cdvnqfjz 20 7 have have VBP cord-004825-cdvnqfjz 20 8 been be VBN cord-004825-cdvnqfjz 20 9 described describe VBN cord-004825-cdvnqfjz 20 10 , , , cord-004825-cdvnqfjz 20 11 the the DT cord-004825-cdvnqfjz 20 12 early early JJ cord-004825-cdvnqfjz 20 13 events event NNS cord-004825-cdvnqfjz 20 14 of of IN cord-004825-cdvnqfjz 20 15 the the DT cord-004825-cdvnqfjz 20 16 multiplication multiplication NN cord-004825-cdvnqfjz 20 17 cycle cycle NN cord-004825-cdvnqfjz 20 18 remain remain VBP cord-004825-cdvnqfjz 20 19 poorly poorly RB cord-004825-cdvnqfjz 20 20 characterized characterize VBN cord-004825-cdvnqfjz 20 21 . . . cord-004825-cdvnqfjz 21 1 Main main JJ cord-004825-cdvnqfjz 21 2 interest interest NN cord-004825-cdvnqfjz 21 3 has have VBZ cord-004825-cdvnqfjz 21 4 been be VBN cord-004825-cdvnqfjz 21 5 focussed focusse VBN cord-004825-cdvnqfjz 21 6 on on IN cord-004825-cdvnqfjz 21 7 the the DT cord-004825-cdvnqfjz 21 8 knowledge knowledge NN cord-004825-cdvnqfjz 21 9 of of IN cord-004825-cdvnqfjz 21 10 viral viral JJ cord-004825-cdvnqfjz 21 11 RNA RNA NNP cord-004825-cdvnqfjz 21 12 transcription transcription NN cord-004825-cdvnqfjz 21 13 and and CC cord-004825-cdvnqfjz 21 14 replication replication NN cord-004825-cdvnqfjz 21 15 , , , cord-004825-cdvnqfjz 21 16 the the DT cord-004825-cdvnqfjz 21 17 characterization characterization NN cord-004825-cdvnqfjz 21 18 of of IN cord-004825-cdvnqfjz 21 19 the the DT cord-004825-cdvnqfjz 21 20 ambisense ambisense NN cord-004825-cdvnqfjz 21 21 genome genome NN cord-004825-cdvnqfjz 21 22 strategy strategy NN cord-004825-cdvnqfjz 21 23 and and CC cord-004825-cdvnqfjz 21 24 the the DT cord-004825-cdvnqfjz 21 25 study study NN cord-004825-cdvnqfjz 21 26 of of IN cord-004825-cdvnqfjz 21 27 protein protein NN cord-004825-cdvnqfjz 21 28 structure structure NN cord-004825-cdvnqfjz 21 29 and and CC cord-004825-cdvnqfjz 21 30 expression expression NN cord-004825-cdvnqfjz 21 31 [ [ -LRB- cord-004825-cdvnqfjz 21 32 -2 -2 NNP cord-004825-cdvnqfjz 21 33 , , , cord-004825-cdvnqfjz 21 34 3 3 CD cord-004825-cdvnqfjz 21 35 ] ] -RRB- cord-004825-cdvnqfjz 21 36 . . . cord-004825-cdvnqfjz 22 1 Little little JJ cord-004825-cdvnqfjz 22 2 is be VBZ cord-004825-cdvnqfjz 22 3 known know VBN cord-004825-cdvnqfjz 22 4 about about IN cord-004825-cdvnqfjz 22 5 the the DT cord-004825-cdvnqfjz 22 6 process process NN cord-004825-cdvnqfjz 22 7 of of IN cord-004825-cdvnqfjz 22 8 virus virus NN cord-004825-cdvnqfjz 22 9 attachment attachment NN cord-004825-cdvnqfjz 22 10 and and CC cord-004825-cdvnqfjz 22 11 entry entry NN cord-004825-cdvnqfjz 22 12 into into IN cord-004825-cdvnqfjz 22 13 the the DT cord-004825-cdvnqfjz 22 14 cell cell NN cord-004825-cdvnqfjz 22 15 . . . cord-004825-cdvnqfjz 23 1 A a DT cord-004825-cdvnqfjz 23 2 brief brief JJ cord-004825-cdvnqfjz 23 3 report report NN cord-004825-cdvnqfjz 23 4 has have VBZ cord-004825-cdvnqfjz 23 5 recently recently RB cord-004825-cdvnqfjz 23 6 suggested suggest VBN cord-004825-cdvnqfjz 23 7 that that IN cord-004825-cdvnqfjz 23 8 the the DT cord-004825-cdvnqfjz 23 9 replication replication NN cord-004825-cdvnqfjz 23 10 of of IN cord-004825-cdvnqfjz 23 11 the the DT cord-004825-cdvnqfjz 23 12 arenaviruses arenavirus NNS cord-004825-cdvnqfjz 23 13 Pichinde Pichinde NNP cord-004825-cdvnqfjz 23 14 , , , cord-004825-cdvnqfjz 23 15 Mopeia Mopeia NNPS cord-004825-cdvnqfjz 23 16 and and CC cord-004825-cdvnqfjz 23 17 Lassa Lassa NNP cord-004825-cdvnqfjz 23 18 was be VBD cord-004825-cdvnqfjz 23 19 sensitive sensitive JJ cord-004825-cdvnqfjz 23 20 to to IN cord-004825-cdvnqfjz 23 21 some some DT cord-004825-cdvnqfjz 23 22 lysosomotropic lysosomotropic JJ cord-004825-cdvnqfjz 23 23 compounds compound NNS cord-004825-cdvnqfjz 23 24 [ [ -LRB- cord-004825-cdvnqfjz 23 25 8 8 CD cord-004825-cdvnqfjz 23 26 ] ] -RRB- cord-004825-cdvnqfjz 23 27 . . . cord-004825-cdvnqfjz 24 1 Two two CD cord-004825-cdvnqfjz 24 2 distinct distinct JJ cord-004825-cdvnqfjz 24 3 pathways pathway NNS cord-004825-cdvnqfjz 24 4 operate operate VBP cord-004825-cdvnqfjz 24 5 for for IN cord-004825-cdvnqfjz 24 6 the the DT cord-004825-cdvnqfjz 24 7 entry entry NN cord-004825-cdvnqfjz 24 8 of of IN cord-004825-cdvnqfjz 24 9 enveloped envelop VBN cord-004825-cdvnqfjz 24 10 viruses virus NNS cord-004825-cdvnqfjz 24 11 into into IN cord-004825-cdvnqfjz 24 12 animal animal NN cord-004825-cdvnqfjz 24 13 cells cell NNS cord-004825-cdvnqfjz 24 14 : : : cord-004825-cdvnqfjz 24 15 some some DT cord-004825-cdvnqfjz 24 16 viruses virus NNS cord-004825-cdvnqfjz 24 17 penetrate penetrate VBP cord-004825-cdvnqfjz 24 18 by by IN cord-004825-cdvnqfjz 24 19 direct direct JJ cord-004825-cdvnqfjz 24 20 fusion fusion NN cord-004825-cdvnqfjz 24 21 of of IN cord-004825-cdvnqfjz 24 22 the the DT cord-004825-cdvnqfjz 24 23 viral viral JJ cord-004825-cdvnqfjz 24 24 envelope envelope NN cord-004825-cdvnqfjz 24 25 with with IN cord-004825-cdvnqfjz 24 26 the the DT cord-004825-cdvnqfjz 24 27 plasma plasma NN cord-004825-cdvnqfjz 24 28 membrane membrane NN cord-004825-cdvnqfjz 24 29 while while IN cord-004825-cdvnqfjz 24 30 other other JJ cord-004825-cdvnqfjz 24 31 viruses virus NNS cord-004825-cdvnqfjz 24 32 are be VBP cord-004825-cdvnqfjz 24 33 taken take VBN cord-004825-cdvnqfjz 24 34 up up RP cord-004825-cdvnqfjz 24 35 by by IN cord-004825-cdvnqfjz 24 36 an an DT cord-004825-cdvnqfjz 24 37 endocytic endocytic JJ cord-004825-cdvnqfjz 24 38 mechanism mechanism NN cord-004825-cdvnqfjz 24 39 [ [ -LRB- cord-004825-cdvnqfjz 24 40 15 15 CD cord-004825-cdvnqfjz 24 41 ] ] -RRB- cord-004825-cdvnqfjz 24 42 . . . cord-004825-cdvnqfjz 25 1 The the DT cord-004825-cdvnqfjz 25 2 endocytosed endocytosed JJ cord-004825-cdvnqfjz 25 3 virions virion NNS cord-004825-cdvnqfjz 25 4 travel travel VBP cord-004825-cdvnqfjz 25 5 to to IN cord-004825-cdvnqfjz 25 6 intracellular intracellular JJ cord-004825-cdvnqfjz 25 7 compartments compartment NNS cord-004825-cdvnqfjz 25 8 where where WRB cord-004825-cdvnqfjz 25 9 acidic acidic JJ cord-004825-cdvnqfjz 25 10 conditions condition NNS cord-004825-cdvnqfjz 25 11 facilitate facilitate VBP cord-004825-cdvnqfjz 25 12 fusion fusion NN cord-004825-cdvnqfjz 25 13 between between IN cord-004825-cdvnqfjz 25 14 the the DT cord-004825-cdvnqfjz 25 15 viral viral JJ cord-004825-cdvnqfjz 25 16 envelope envelope NN cord-004825-cdvnqfjz 25 17 and and CC cord-004825-cdvnqfjz 25 18 the the DT cord-004825-cdvnqfjz 25 19 vesicle vesicle NN cord-004825-cdvnqfjz 25 20 membrane membrane NN cord-004825-cdvnqfjz 25 21 releasing release VBG cord-004825-cdvnqfjz 25 22 the the DT cord-004825-cdvnqfjz 25 23 nucleocapsid nucleocapsid NN cord-004825-cdvnqfjz 25 24 into into IN cord-004825-cdvnqfjz 25 25 the the DT cord-004825-cdvnqfjz 25 26 cytoplasm cytoplasm NN cord-004825-cdvnqfjz 25 27 . . . cord-004825-cdvnqfjz 26 1 Thus thus RB cord-004825-cdvnqfjz 26 2 , , , cord-004825-cdvnqfjz 26 3 lysosomotropic lysosomotropic JJ cord-004825-cdvnqfjz 26 4 agents agent NNS cord-004825-cdvnqfjz 26 5 such such JJ cord-004825-cdvnqfjz 26 6 as as IN cord-004825-cdvnqfjz 26 7 weak weak JJ cord-004825-cdvnqfjz 26 8 bases basis NNS cord-004825-cdvnqfjz 26 9 and and CC cord-004825-cdvnqfjz 26 10 carboxylic carboxylic JJ cord-004825-cdvnqfjz 26 11 ionophores ionophore NNS cord-004825-cdvnqfjz 26 12 that that WDT cord-004825-cdvnqfjz 26 13 elevate elevate VBP cord-004825-cdvnqfjz 26 14 the the DT cord-004825-cdvnqfjz 26 15 pH ph NN cord-004825-cdvnqfjz 26 16 of of IN cord-004825-cdvnqfjz 26 17 acidic acidic JJ cord-004825-cdvnqfjz 26 18 organelles organelle NNS cord-004825-cdvnqfjz 26 19 , , , cord-004825-cdvnqfjz 26 20 interfere interfere VB cord-004825-cdvnqfjz 26 21 with with IN cord-004825-cdvnqfjz 26 22 the the DT cord-004825-cdvnqfjz 26 23 virion virion NN cord-004825-cdvnqfjz 26 24 uncoating uncoate VBG cord-004825-cdvnqfjz 26 25 and and CC cord-004825-cdvnqfjz 26 26 inhibit inhibit VB cord-004825-cdvnqfjz 26 27 the the DT cord-004825-cdvnqfjz 26 28 replication replication NN cord-004825-cdvnqfjz 26 29 [ [ -LRB- cord-004825-cdvnqfjz 26 30 1 1 CD cord-004825-cdvnqfjz 26 31 , , , cord-004825-cdvnqfjz 26 32 9 9 CD cord-004825-cdvnqfjz 26 33 , , , cord-004825-cdvnqfjz 26 34 14 14 CD cord-004825-cdvnqfjz 26 35 ] ] -RRB- cord-004825-cdvnqfjz 26 36 . . . cord-004825-cdvnqfjz 27 1 The the DT cord-004825-cdvnqfjz 27 2 uncharged uncharged JJ cord-004825-cdvnqfjz 27 3 form form NN cord-004825-cdvnqfjz 27 4 of of IN cord-004825-cdvnqfjz 27 5 any any DT cord-004825-cdvnqfjz 27 6 weak weak JJ cord-004825-cdvnqfjz 27 7 base base NN cord-004825-cdvnqfjz 27 8 has have VBZ cord-004825-cdvnqfjz 27 9 been be VBN cord-004825-cdvnqfjz 27 10 proposed propose VBN cord-004825-cdvnqfjz 27 11 to to TO cord-004825-cdvnqfjz 27 12 enter enter VB cord-004825-cdvnqfjz 27 13 the the DT cord-004825-cdvnqfjz 27 14 acidic acidic JJ cord-004825-cdvnqfjz 27 15 intracellular intracellular JJ cord-004825-cdvnqfjz 27 16 compartments compartment NNS cord-004825-cdvnqfjz 27 17 very very RB cord-004825-cdvnqfjz 27 18 efficiently efficiently RB cord-004825-cdvnqfjz 27 19 , , , cord-004825-cdvnqfjz 27 20 raising raise VBG cord-004825-cdvnqfjz 27 21 the the DT cord-004825-cdvnqfjz 27 22 pH ph NN cord-004825-cdvnqfjz 27 23 as as IN cord-004825-cdvnqfjz 27 24 it -PRON- PRP cord-004825-cdvnqfjz 27 25 becomes become VBZ cord-004825-cdvnqfjz 27 26 protonated protonated JJ cord-004825-cdvnqfjz 27 27 and and CC cord-004825-cdvnqfjz 27 28 inhibiting inhibit VBG cord-004825-cdvnqfjz 27 29 hydrolytic hydrolytic JJ cord-004825-cdvnqfjz 27 30 enzymes enzyme NNS cord-004825-cdvnqfjz 27 31 [ [ -LRB- cord-004825-cdvnqfjz 27 32 15 15 CD cord-004825-cdvnqfjz 27 33 ] ] -RRB- cord-004825-cdvnqfjz 27 34 . . . cord-004825-cdvnqfjz 28 1 In in IN cord-004825-cdvnqfjz 28 2 this this DT cord-004825-cdvnqfjz 28 3 paper paper NN cord-004825-cdvnqfjz 28 4 , , , cord-004825-cdvnqfjz 28 5 we -PRON- PRP cord-004825-cdvnqfjz 28 6 report report VBP cord-004825-cdvnqfjz 28 7 studies study NNS cord-004825-cdvnqfjz 28 8 on on IN cord-004825-cdvnqfjz 28 9 JV JV NNP cord-004825-cdvnqfjz 28 10 penetration penetration NN cord-004825-cdvnqfjz 28 11 into into IN cord-004825-cdvnqfjz 28 12 Vero Vero NNP cord-004825-cdvnqfjz 28 13 cells cell NNS cord-004825-cdvnqfjz 28 14 analyzing analyze VBG cord-004825-cdvnqfjz 28 15 the the DT cord-004825-cdvnqfjz 28 16 effect effect NN cord-004825-cdvnqfjz 28 17 of of IN cord-004825-cdvnqfjz 28 18 acidic acidic JJ cord-004825-cdvnqfjz 28 19 pH ph NN cord-004825-cdvnqfjz 28 20 and and CC cord-004825-cdvnqfjz 28 21 lysosomotropic lysosomotropic JJ cord-004825-cdvnqfjz 28 22 bases basis NNS cord-004825-cdvnqfjz 28 23 on on IN cord-004825-cdvnqfjz 28 24 virus virus NN cord-004825-cdvnqfjz 28 25 entry entry NN cord-004825-cdvnqfjz 28 26 . . . cord-004825-cdvnqfjz 29 1 Monolayers monolayer NNS cord-004825-cdvnqfjz 29 2 of of IN cord-004825-cdvnqfjz 29 3 Vero Vero NNP cord-004825-cdvnqfjz 29 4 cells cell NNS cord-004825-cdvnqfjz 29 5 were be VBD cord-004825-cdvnqfjz 29 6 grown grow VBN cord-004825-cdvnqfjz 29 7 in in IN cord-004825-cdvnqfjz 29 8 Minimum Minimum NNP cord-004825-cdvnqfjz 29 9 Essential Essential NNP cord-004825-cdvnqfjz 29 10 Medium Medium NNP cord-004825-cdvnqfjz 29 11 ( ( -LRB- cord-004825-cdvnqfjz 29 12 MEM MEM NNP cord-004825-cdvnqfjz 29 13 ) ) -RRB- cord-004825-cdvnqfjz 29 14 supplemented supplement VBD cord-004825-cdvnqfjz 29 15 with with IN cord-004825-cdvnqfjz 29 16 5 5 CD cord-004825-cdvnqfjz 29 17 % % NN cord-004825-cdvnqfjz 29 18 calf calf NN cord-004825-cdvnqfjz 29 19 serum serum NN cord-004825-cdvnqfjz 29 20 and and CC cord-004825-cdvnqfjz 29 21 gentamycin gentamycin NNS cord-004825-cdvnqfjz 29 22 . . . cord-004825-cdvnqfjz 30 1 The the DT cord-004825-cdvnqfjz 30 2 IV4454 iv4454 NN cord-004825-cdvnqfjz 30 3 strain strain NN cord-004825-cdvnqfjz 30 4 of of IN cord-004825-cdvnqfjz 30 5 JV JV NNP cord-004825-cdvnqfjz 30 6 [ [ -LRB- cord-004825-cdvnqfjz 30 7 4 4 CD cord-004825-cdvnqfjz 30 8 ] ] -RRB- cord-004825-cdvnqfjz 30 9 was be VBD cord-004825-cdvnqfjz 30 10 used use VBN cord-004825-cdvnqfjz 30 11 . . . cord-004825-cdvnqfjz 31 1 Stock stock NN cord-004825-cdvnqfjz 31 2 solutions solution NNS cord-004825-cdvnqfjz 31 3 of of IN cord-004825-cdvnqfjz 31 4 amantadine amantadine NNP cord-004825-cdvnqfjz 31 5 ( ( -LRB- cord-004825-cdvnqfjz 31 6 SPECIA SPECIA NNP cord-004825-cdvnqfjz 31 7 ) ) -RRB- cord-004825-cdvnqfjz 31 8 , , , cord-004825-cdvnqfjz 31 9 ammonium ammonium NN cord-004825-cdvnqfjz 31 10 chloride chloride NN cord-004825-cdvnqfjz 31 11 ( ( -LRB- cord-004825-cdvnqfjz 31 12 Fisher Fisher NNP cord-004825-cdvnqfjz 31 13 Company Company NNP cord-004825-cdvnqfjz 31 14 ) ) -RRB- cord-004825-cdvnqfjz 31 15 , , , cord-004825-cdvnqfjz 31 16 chlorpheniramine chlorpheniramine NNP cord-004825-cdvnqfjz 31 17 ( ( -LRB- cord-004825-cdvnqfjz 31 18 Schering Schering NNP cord-004825-cdvnqfjz 31 19 - - HYPH cord-004825-cdvnqfjz 31 20 Plough Plough NNP cord-004825-cdvnqfjz 31 21 ) ) -RRB- cord-004825-cdvnqfjz 31 22 and and CC cord-004825-cdvnqfjz 31 23 procaine procaine NN cord-004825-cdvnqfjz 31 24 ( ( -LRB- cord-004825-cdvnqfjz 31 25 Schering Schering NNP cord-004825-cdvnqfjz 31 26 - - HYPH cord-004825-cdvnqfjz 31 27 Plough Plough NNP cord-004825-cdvnqfjz 31 28 ) ) -RRB- cord-004825-cdvnqfjz 31 29 at at IN cord-004825-cdvnqfjz 31 30 concentrations concentration NNS cord-004825-cdvnqfjz 31 31 of of IN cord-004825-cdvnqfjz 31 32 5 5 CD cord-004825-cdvnqfjz 31 33 , , , cord-004825-cdvnqfjz 31 34 500 500 CD cord-004825-cdvnqfjz 31 35 , , , cord-004825-cdvnqfjz 31 36 100 100 CD cord-004825-cdvnqfjz 31 37 and and CC cord-004825-cdvnqfjz 31 38 50mM 50mm CD cord-004825-cdvnqfjz 31 39 , , , cord-004825-cdvnqfjz 31 40 respectively respectively RB cord-004825-cdvnqfjz 31 41 , , , cord-004825-cdvnqfjz 31 42 were be VBD cord-004825-cdvnqfjz 31 43 prepared prepare VBN cord-004825-cdvnqfjz 31 44 in in IN cord-004825-cdvnqfjz 31 45 culture culture NN cord-004825-cdvnqfjz 31 46 medium medium NN cord-004825-cdvnqfjz 31 47 and and CC cord-004825-cdvnqfjz 31 48 sterilized sterilize VBN cord-004825-cdvnqfjz 31 49 by by IN cord-004825-cdvnqfjz 31 50 filtration filtration NN cord-004825-cdvnqfjz 31 51 . . . cord-004825-cdvnqfjz 32 1 Ammonium ammonium NN cord-004825-cdvnqfjz 32 2 chloride chloride NN cord-004825-cdvnqfjz 32 3 ( ( -LRB- cord-004825-cdvnqfjz 32 4 15mM 15mm CD cord-004825-cdvnqfjz 32 5 ) ) -RRB- cord-004825-cdvnqfjz 32 6 was be VBD cord-004825-cdvnqfjz 32 7 added add VBN cord-004825-cdvnqfjz 32 8 to to IN cord-004825-cdvnqfjz 32 9 Vero Vero NNP cord-004825-cdvnqfjz 32 10 cells cell NNS cord-004825-cdvnqfjz 32 11 1 1 CD cord-004825-cdvnqfjz 32 12 h h NN cord-004825-cdvnqfjz 32 13 before before IN cord-004825-cdvnqfjz 32 14 infection infection NN cord-004825-cdvnqfjz 32 15 with with IN cord-004825-cdvnqfjz 32 16 JV JV NNP cord-004825-cdvnqfjz 32 17 or or CC cord-004825-cdvnqfjz 32 18 at at IN cord-004825-cdvnqfjz 32 19 0 0 CD cord-004825-cdvnqfjz 32 20 , , , cord-004825-cdvnqfjz 32 21 t t NN cord-004825-cdvnqfjz 32 22 , , , cord-004825-cdvnqfjz 32 23 3 3 CD cord-004825-cdvnqfjz 32 24 , , , cord-004825-cdvnqfjz 32 25 5 5 CD cord-004825-cdvnqfjz 32 26 or or CC cord-004825-cdvnqfjz 32 27 8 8 CD cord-004825-cdvnqfjz 32 28 h h NN cord-004825-cdvnqfjz 32 29 post post NN cord-004825-cdvnqfjz 32 30 - - NN cord-004825-cdvnqfjz 32 31 infection infection JJ cord-004825-cdvnqfjz 32 32 ( ( -LRB- cord-004825-cdvnqfjz 32 33 p.i p.i NNP cord-004825-cdvnqfjz 32 34 . . NNP cord-004825-cdvnqfjz 32 35 ) ) -RRB- cord-004825-cdvnqfjz 32 36 . . . cord-004825-cdvnqfjz 33 1 In in IN cord-004825-cdvnqfjz 33 2 all all DT cord-004825-cdvnqfjz 33 3 cases case NNS cord-004825-cdvnqfjz 33 4 supernatant supernatant JJ cord-004825-cdvnqfjz 33 5 cultures culture NNS cord-004825-cdvnqfjz 33 6 were be VBD cord-004825-cdvnqfjz 33 7 harvested harvest VBN cord-004825-cdvnqfjz 33 8 at at IN cord-004825-cdvnqfjz 33 9 24 24 CD cord-004825-cdvnqfjz 33 10 h h NN cord-004825-cdvnqfjz 33 11 p.i p.i NNP cord-004825-cdvnqfjz 33 12 . . NNP cord-004825-cdvnqfjz 33 13 and and CC cord-004825-cdvnqfjz 33 14 extracellular extracellular JJ cord-004825-cdvnqfjz 33 15 virus virus NN cord-004825-cdvnqfjz 33 16 yields yield NNS cord-004825-cdvnqfjz 33 17 were be VBD cord-004825-cdvnqfjz 33 18 determined determine VBN cord-004825-cdvnqfjz 33 19 by by IN cord-004825-cdvnqfjz 33 20 plaque plaque NN cord-004825-cdvnqfjz 33 21 assay assay NN cord-004825-cdvnqfjz 33 22 . . . cord-004825-cdvnqfjz 34 1 Vero Vero NNP cord-004825-cdvnqfjz 34 2 cells cell NNS cord-004825-cdvnqfjz 34 3 were be VBD cord-004825-cdvnqfjz 34 4 infected infect VBN cord-004825-cdvnqfjz 34 5 with with IN cord-004825-cdvnqfjz 34 6 JV JV NNP cord-004825-cdvnqfjz 34 7 ( ( -LRB- cord-004825-cdvnqfjz 34 8 virus virus NN cord-004825-cdvnqfjz 34 9 inoculum inoculum NN cord-004825-cdvnqfjz 34 10 : : : cord-004825-cdvnqfjz 34 11 2 2 CD cord-004825-cdvnqfjz 34 12 × × NN cord-004825-cdvnqfjz 34 13 105 105 CD cord-004825-cdvnqfjz 34 14 PFU PFU NNP cord-004825-cdvnqfjz 34 15 ) ) -RRB- cord-004825-cdvnqfjz 34 16 in in IN cord-004825-cdvnqfjz 34 17 the the DT cord-004825-cdvnqfjz 34 18 presence presence NN cord-004825-cdvnqfjz 34 19 or or CC cord-004825-cdvnqfjz 34 20 in in IN cord-004825-cdvnqfjz 34 21 the the DT cord-004825-cdvnqfjz 34 22 absence absence NN cord-004825-cdvnqfjz 34 23 of of IN cord-004825-cdvnqfjz 34 24 15mM 15mm CD cord-004825-cdvnqfjz 34 25 ammonium ammonium NN cord-004825-cdvnqfjz 34 26 chloride chloride NN cord-004825-cdvnqfjz 34 27 . . . cord-004825-cdvnqfjz 35 1 After after IN cord-004825-cdvnqfjz 35 2 adsorption adsorption NN cord-004825-cdvnqfjz 35 3 for for IN cord-004825-cdvnqfjz 35 4 0 0 CD cord-004825-cdvnqfjz 35 5 , , , cord-004825-cdvnqfjz 35 6 10,20,30 10,20,30 CD cord-004825-cdvnqfjz 35 7 , , , cord-004825-cdvnqfjz 35 8 and and CC cord-004825-cdvnqfjz 35 9 60rain 60rain CD cord-004825-cdvnqfjz 35 10 at at IN cord-004825-cdvnqfjz 35 11 4 4 CD cord-004825-cdvnqfjz 35 12 ° ° NN cord-004825-cdvnqfjz 35 13 C c NN cord-004825-cdvnqfjz 35 14 , , , cord-004825-cdvnqfjz 35 15 infected infected JJ cord-004825-cdvnqfjz 35 16 cells cell NNS cord-004825-cdvnqfjz 35 17 were be VBD cord-004825-cdvnqfjz 35 18 washed wash VBN cord-004825-cdvnqfjz 35 19 twice twice RB cord-004825-cdvnqfjz 35 20 with with IN cord-004825-cdvnqfjz 35 21 cold cold JJ cord-004825-cdvnqfjz 35 22 phosphate phosphate NN cord-004825-cdvnqfjz 35 23 buffer buffer NN cord-004825-cdvnqfjz 35 24 saline saline NN cord-004825-cdvnqfjz 35 25 ( ( -LRB- cord-004825-cdvnqfjz 35 26 PBS PBS NNP cord-004825-cdvnqfjz 35 27 ) ) -RRB- cord-004825-cdvnqfjz 35 28 and and CC cord-004825-cdvnqfjz 35 29 disrupted disrupt VBN cord-004825-cdvnqfjz 35 30 by by IN cord-004825-cdvnqfjz 35 31 freezing freeze VBG cord-004825-cdvnqfjz 35 32 and and CC cord-004825-cdvnqfjz 35 33 thawing thawing NN cord-004825-cdvnqfjz 35 34 . . . cord-004825-cdvnqfjz 36 1 The the DT cord-004825-cdvnqfjz 36 2 amount amount NN cord-004825-cdvnqfjz 36 3 of of IN cord-004825-cdvnqfjz 36 4 infectious infectious JJ cord-004825-cdvnqfjz 36 5 bound bind VBN cord-004825-cdvnqfjz 36 6 virus virus NN cord-004825-cdvnqfjz 36 7 was be VBD cord-004825-cdvnqfjz 36 8 then then RB cord-004825-cdvnqfjz 36 9 determined determine VBN cord-004825-cdvnqfjz 36 10 by by IN cord-004825-cdvnqfjz 36 11 plaque plaque NN cord-004825-cdvnqfjz 36 12 assay assay NN cord-004825-cdvnqfjz 36 13 . . . cord-004825-cdvnqfjz 37 1 Cultures culture NNS cord-004825-cdvnqfjz 37 2 of of IN cord-004825-cdvnqfjz 37 3 Vero Vero NNP cord-004825-cdvnqfjz 37 4 cells cell NNS cord-004825-cdvnqfjz 37 5 were be VBD cord-004825-cdvnqfjz 37 6 infected infect VBN cord-004825-cdvnqfjz 37 7 with with IN cord-004825-cdvnqfjz 37 8 JV JV NNP cord-004825-cdvnqfjz 37 9 at at IN cord-004825-cdvnqfjz 37 10 a a DT cord-004825-cdvnqfjz 37 11 moi moi NN cord-004825-cdvnqfjz 37 12 of of IN cord-004825-cdvnqfjz 37 13 1 1 CD cord-004825-cdvnqfjz 37 14 . . . cord-004825-cdvnqfjz 38 1 After after IN cord-004825-cdvnqfjz 38 2 30 30 CD cord-004825-cdvnqfjz 38 3 rain rain NN cord-004825-cdvnqfjz 38 4 adsorption adsorption NN cord-004825-cdvnqfjz 38 5 at at IN cord-004825-cdvnqfjz 38 6 4 4 CD cord-004825-cdvnqfjz 38 7 ° ° NN cord-004825-cdvnqfjz 38 8 C C NNP cord-004825-cdvnqfjz 38 9 two two CD cord-004825-cdvnqfjz 38 10 washes wash NNS cord-004825-cdvnqfjz 38 11 were be VBD cord-004825-cdvnqfjz 38 12 done do VBN cord-004825-cdvnqfjz 38 13 to to TO cord-004825-cdvnqfjz 38 14 remove remove VB cord-004825-cdvnqfjz 38 15 excess excess JJ cord-004825-cdvnqfjz 38 16 inoculum inoculum NN cord-004825-cdvnqfjz 38 17 and and CC cord-004825-cdvnqfjz 38 18 then then RB cord-004825-cdvnqfjz 38 19 cultures culture NNS cord-004825-cdvnqfjz 38 20 were be VBD cord-004825-cdvnqfjz 38 21 warmed warm VBN cord-004825-cdvnqfjz 38 22 to to IN cord-004825-cdvnqfjz 38 23 37 37 CD cord-004825-cdvnqfjz 38 24 ° ° NN cord-004825-cdvnqfjz 38 25 C c NN cord-004825-cdvnqfjz 38 26 for for IN cord-004825-cdvnqfjz 38 27 various various JJ cord-004825-cdvnqfjz 38 28 times time NNS cord-004825-cdvnqfjz 38 29 in in IN cord-004825-cdvnqfjz 38 30 the the DT cord-004825-cdvnqfjz 38 31 presence presence NN cord-004825-cdvnqfjz 38 32 or or CC cord-004825-cdvnqfjz 38 33 absence absence NN cord-004825-cdvnqfjz 38 34 of of IN cord-004825-cdvnqfjz 38 35 15 15 CD cord-004825-cdvnqfjz 38 36 mM mm CD cord-004825-cdvnqfjz 38 37 ammonium ammonium NN cord-004825-cdvnqfjz 38 38 chloride chloride NN cord-004825-cdvnqfjz 38 39 . . . cord-004825-cdvnqfjz 39 1 Cultures culture NNS cord-004825-cdvnqfjz 39 2 were be VBD cord-004825-cdvnqfjz 39 3 subsequently subsequently RB cord-004825-cdvnqfjz 39 4 treated treat VBN cord-004825-cdvnqfjz 39 5 with with IN cord-004825-cdvnqfjz 39 6 proteinase proteinase NN cord-004825-cdvnqfjz 39 7 K K NNP cord-004825-cdvnqfjz 39 8 ( ( -LRB- cord-004825-cdvnqfjz 39 9 0.25 0.25 CD cord-004825-cdvnqfjz 39 10 mg mg NNP cord-004825-cdvnqfjz 39 11 / / SYM cord-004825-cdvnqfjz 39 12 ml ml NNP cord-004825-cdvnqfjz 39 13 ) ) -RRB- cord-004825-cdvnqfjz 39 14 in in IN cord-004825-cdvnqfjz 39 15 PBS PBS NNP cord-004825-cdvnqfjz 39 16 for for IN cord-004825-cdvnqfjz 39 17 30 30 CD cord-004825-cdvnqfjz 39 18 min min NN cord-004825-cdvnqfjz 39 19 at at IN cord-004825-cdvnqfjz 39 20 4 4 CD cord-004825-cdvnqfjz 39 21 ° ° NN cord-004825-cdvnqfjz 39 22 C c NN cord-004825-cdvnqfjz 39 23 in in IN cord-004825-cdvnqfjz 39 24 order order NN cord-004825-cdvnqfjz 39 25 to to TO cord-004825-cdvnqfjz 39 26 remove remove VB cord-004825-cdvnqfjz 39 27 external external JJ cord-004825-cdvnqfjz 39 28 virus virus NN cord-004825-cdvnqfjz 39 29 . . . cord-004825-cdvnqfjz 40 1 Protease protease NN cord-004825-cdvnqfjz 40 2 treatment treatment NN cord-004825-cdvnqfjz 40 3 was be VBD cord-004825-cdvnqfjz 40 4 stopped stop VBN cord-004825-cdvnqfjz 40 5 by by IN cord-004825-cdvnqfjz 40 6 the the DT cord-004825-cdvnqfjz 40 7 addition addition NN cord-004825-cdvnqfjz 40 8 of of IN cord-004825-cdvnqfjz 40 9 2mM 2mm CD cord-004825-cdvnqfjz 40 10 phenyl phenyl NN cord-004825-cdvnqfjz 40 11 methyl methyl NN cord-004825-cdvnqfjz 40 12 sulfonyl sulfonyl NN cord-004825-cdvnqfjz 40 13 fluoride fluoride NN cord-004825-cdvnqfjz 40 14 ( ( -LRB- cord-004825-cdvnqfjz 40 15 PMSF PMSF NNP cord-004825-cdvnqfjz 40 16 ) ) -RRB- cord-004825-cdvnqfjz 40 17 , , , cord-004825-cdvnqfjz 40 18 3~ 3~ CD cord-004825-cdvnqfjz 40 19 bovine bovine JJ cord-004825-cdvnqfjz 40 20 serum serum NN cord-004825-cdvnqfjz 40 21 albumin albumin NN cord-004825-cdvnqfjz 40 22 ( ( -LRB- cord-004825-cdvnqfjz 40 23 BSA BSA NNP cord-004825-cdvnqfjz 40 24 ) ) -RRB- cord-004825-cdvnqfjz 40 25 in in IN cord-004825-cdvnqfjz 40 26 PBS PBS NNP cord-004825-cdvnqfjz 40 27 . . . cord-004825-cdvnqfjz 41 1 Cells cell NNS cord-004825-cdvnqfjz 41 2 were be VBD cord-004825-cdvnqfjz 41 3 centrifuged centrifuge VBN cord-004825-cdvnqfjz 41 4 10 10 CD cord-004825-cdvnqfjz 41 5 min min NN cord-004825-cdvnqfjz 41 6 at at IN cord-004825-cdvnqfjz 41 7 2 2 CD cord-004825-cdvnqfjz 41 8 000 000 CD cord-004825-cdvnqfjz 41 9 g g NN cord-004825-cdvnqfjz 41 10 and and CC cord-004825-cdvnqfjz 41 11 the the DT cord-004825-cdvnqfjz 41 12 resultant resultant JJ cord-004825-cdvnqfjz 41 13 pellet pellet NN cord-004825-cdvnqfjz 41 14 was be VBD cord-004825-cdvnqfjz 41 15 washed wash VBN cord-004825-cdvnqfjz 41 16 and and CC cord-004825-cdvnqfjz 41 17 resuspended resuspend VBN cord-004825-cdvnqfjz 41 18 in in IN cord-004825-cdvnqfjz 41 19 MEM MEM NNP cord-004825-cdvnqfjz 41 20 . . . cord-004825-cdvnqfjz 42 1 Internalized internalize VBN cord-004825-cdvnqfjz 42 2 virus virus NN cord-004825-cdvnqfjz 42 3 was be VBD cord-004825-cdvnqfjz 42 4 measured measure VBN cord-004825-cdvnqfjz 42 5 by by IN cord-004825-cdvnqfjz 42 6 an an DT cord-004825-cdvnqfjz 42 7 infectious infectious JJ cord-004825-cdvnqfjz 42 8 center center NN cord-004825-cdvnqfjz 42 9 assay assay NN cord-004825-cdvnqfjz 42 10 on on IN cord-004825-cdvnqfjz 42 11 Vero Vero NNP cord-004825-cdvnqfjz 42 12 cells cell NNS cord-004825-cdvnqfjz 42 13 . . . cord-004825-cdvnqfjz 43 1 Vero Vero NNP cord-004825-cdvnqfjz 43 2 cells cell NNS cord-004825-cdvnqfjz 43 3 grown grow VBN cord-004825-cdvnqfjz 43 4 in in IN cord-004825-cdvnqfjz 43 5 coverslips coverslip NNS cord-004825-cdvnqfjz 43 6 were be VBD cord-004825-cdvnqfjz 43 7 infected infect VBN cord-004825-cdvnqfjz 43 8 with with IN cord-004825-cdvnqfjz 43 9 JV JV NNP cord-004825-cdvnqfjz 43 10 ( ( -LRB- cord-004825-cdvnqfjz 43 11 moi moi NNP cord-004825-cdvnqfjz 43 12 1 1 CD cord-004825-cdvnqfjz 43 13 ) ) -RRB- cord-004825-cdvnqfjz 43 14 and and CC cord-004825-cdvnqfjz 43 15 15 15 CD cord-004825-cdvnqfjz 43 16 mM mm CD cord-004825-cdvnqfjz 43 17 ammonium ammonium NN cord-004825-cdvnqfjz 43 18 chloride chloride NN cord-004825-cdvnqfjz 43 19 was be VBD cord-004825-cdvnqfjz 43 20 added add VBN cord-004825-cdvnqfjz 43 21 to to IN cord-004825-cdvnqfjz 43 22 the the DT cord-004825-cdvnqfjz 43 23 culture culture NN cord-004825-cdvnqfjz 43 24 medium medium NN cord-004825-cdvnqfjz 43 25 after after IN cord-004825-cdvnqfjz 43 26 adsorption adsorption NN cord-004825-cdvnqfjz 43 27 . . . cord-004825-cdvnqfjz 44 1 At at IN cord-004825-cdvnqfjz 44 2 24 24 CD cord-004825-cdvnqfjz 44 3 h h NN cord-004825-cdvnqfjz 44 4 p.i p.i NNP cord-004825-cdvnqfjz 44 5 . . NNP cord-004825-cdvnqfjz 44 6 supernatants supernatant NNS cord-004825-cdvnqfjz 44 7 were be VBD cord-004825-cdvnqfjz 44 8 removed remove VBN cord-004825-cdvnqfjz 44 9 . . . cord-004825-cdvnqfjz 45 1 Monolayers monolayer NNS cord-004825-cdvnqfjz 45 2 were be VBD cord-004825-cdvnqfjz 45 3 washed wash VBN cord-004825-cdvnqfjz 45 4 with with IN cord-004825-cdvnqfjz 45 5 cold cold JJ cord-004825-cdvnqfjz 45 6 PBS PBS NNP cord-004825-cdvnqfjz 45 7 , , , cord-004825-cdvnqfjz 45 8 fixed fix VBN cord-004825-cdvnqfjz 45 9 in in IN cord-004825-cdvnqfjz 45 10 methanol methanol NN cord-004825-cdvnqfjz 45 11 and and CC cord-004825-cdvnqfjz 45 12 stained stain VBN cord-004825-cdvnqfjz 45 13 for for IN cord-004825-cdvnqfjz 45 14 cytoplasmic cytoplasmic JJ cord-004825-cdvnqfjz 45 15 immunofluorescence immunofluorescence NN cord-004825-cdvnqfjz 45 16 with with IN cord-004825-cdvnqfjz 45 17 anti anti JJ cord-004825-cdvnqfjz 45 18 - - JJ cord-004825-cdvnqfjz 45 19 JV JV NNP cord-004825-cdvnqfjz 45 20 purified purify VBN cord-004825-cdvnqfjz 45 21 immunoglobulins immunoglobulin NNS cord-004825-cdvnqfjz 45 22 as as IN cord-004825-cdvnqfjz 45 23 previously previously RB cord-004825-cdvnqfjz 45 24 described describe VBN cord-004825-cdvnqfjz 45 25 [ [ -LRB- cord-004825-cdvnqfjz 45 26 23 23 CD cord-004825-cdvnqfjz 45 27 ] ] -RRB- cord-004825-cdvnqfjz 45 28 . . . cord-004825-cdvnqfjz 46 1 Veto veto NN cord-004825-cdvnqfjz 46 2 cell cell NN cord-004825-cdvnqfjz 46 3 monolayers monolayer NNS cord-004825-cdvnqfjz 46 4 in in IN cord-004825-cdvnqfjz 46 5 24-wetl 24-wetl CD cord-004825-cdvnqfjz 46 6 plates plate NNS cord-004825-cdvnqfjz 46 7 were be VBD cord-004825-cdvnqfjz 46 8 adsorbed adsorb VBN cord-004825-cdvnqfjz 46 9 for for IN cord-004825-cdvnqfjz 46 10 1 1 CD cord-004825-cdvnqfjz 46 11 h h NN cord-004825-cdvnqfjz 46 12 at at IN cord-004825-cdvnqfjz 46 13 4 4 CD cord-004825-cdvnqfjz 46 14 ° ° NN cord-004825-cdvnqfjz 46 15 C C NNP cord-004825-cdvnqfjz 46 16 with with IN cord-004825-cdvnqfjz 46 17 JV JV NNP cord-004825-cdvnqfjz 46 18 in in IN cord-004825-cdvnqfjz 46 19 MEM MEM NNP cord-004825-cdvnqfjz 46 20 containing contain VBG cord-004825-cdvnqfjz 46 21 0.2~/o 0.2~/o CD cord-004825-cdvnqfjz 46 22 BSA BSA NNP cord-004825-cdvnqfjz 46 23 , , , cord-004825-cdvnqfjz 46 24 15 15 CD cord-004825-cdvnqfjz 46 25 mM mm CD cord-004825-cdvnqfjz 46 26 HEPES HEPES NNP cord-004825-cdvnqfjz 46 27 , , , cord-004825-cdvnqfjz 46 28 pH pH NNP cord-004825-cdvnqfjz 46 29 7.5 7.5 CD cord-004825-cdvnqfjz 46 30 . . . cord-004825-cdvnqfjz 47 1 In in IN cord-004825-cdvnqfjz 47 2 a a DT cord-004825-cdvnqfjz 47 3 set set NN cord-004825-cdvnqfjz 47 4 of of IN cord-004825-cdvnqfjz 47 5 cultures culture NNS cord-004825-cdvnqfjz 47 6 cells cell NNS cord-004825-cdvnqfjz 47 7 were be VBD cord-004825-cdvnqfjz 47 8 washed wash VBN cord-004825-cdvnqfjz 47 9 twice twice RB cord-004825-cdvnqfjz 47 10 with with IN cord-004825-cdvnqfjz 47 11 PBS PBS NNP cord-004825-cdvnqfjz 47 12 and and CC cord-004825-cdvnqfjz 47 13 then then RB cord-004825-cdvnqfjz 47 14 warmed warm VBD cord-004825-cdvnqfjz 47 15 to to IN cord-004825-cdvnqfjz 47 16 37 37 CD cord-004825-cdvnqfjz 47 17 ° ° NN cord-004825-cdvnqfjz 47 18 C c NN cord-004825-cdvnqfjz 47 19 by by IN cord-004825-cdvnqfjz 47 20 the the DT cord-004825-cdvnqfjz 47 21 addition addition NN cord-004825-cdvnqfjz 47 22 of of IN cord-004825-cdvnqfjz 47 23 pre pre JJ cord-004825-cdvnqfjz 47 24 - - JJ cord-004825-cdvnqfjz 47 25 warmed warm VBN cord-004825-cdvnqfjz 47 26 medium medium NN cord-004825-cdvnqfjz 47 27 buffered buffer VBN cord-004825-cdvnqfjz 47 28 with with IN cord-004825-cdvnqfjz 47 29 10 10 CD cord-004825-cdvnqfjz 47 30 mM mm CD cord-004825-cdvnqfjz 47 31 HEPES HEPES NNP cord-004825-cdvnqfjz 47 32 and and CC cord-004825-cdvnqfjz 47 33 10 10 CD cord-004825-cdvnqfjz 47 34 mM mm CD cord-004825-cdvnqfjz 47 35 1 1 CD cord-004825-cdvnqfjz 47 36 - - HYPH cord-004825-cdvnqfjz 47 37 4-piperazinediethene 4-piperazinediethene CD cord-004825-cdvnqfjz 47 38 - - HYPH cord-004825-cdvnqfjz 47 39 sulfonic sulfonic JJ cord-004825-cdvnqfjz 47 40 acid acid NN cord-004825-cdvnqfjz 47 41 ( ( -LRB- cord-004825-cdvnqfjz 47 42 PIPES pipes NN cord-004825-cdvnqfjz 47 43 ) ) -RRB- cord-004825-cdvnqfjz 47 44 at at IN cord-004825-cdvnqfjz 47 45 pH pH NNP cord-004825-cdvnqfjz 47 46 5.5 5.5 CD cord-004825-cdvnqfjz 47 47 , , , cord-004825-cdvnqfjz 47 48 5.8 5.8 CD cord-004825-cdvnqfjz 47 49 , , , cord-004825-cdvnqfjz 47 50 6.1 6.1 CD cord-004825-cdvnqfjz 47 51 , , , cord-004825-cdvnqfjz 47 52 6.3 6.3 CD cord-004825-cdvnqfjz 47 53 , , , cord-004825-cdvnqfjz 47 54 6.6 6.6 CD cord-004825-cdvnqfjz 47 55 and and CC cord-004825-cdvnqfjz 47 56 7.5 7.5 CD cord-004825-cdvnqfjz 47 57 , , , cord-004825-cdvnqfjz 47 58 in in IN cord-004825-cdvnqfjz 47 59 the the DT cord-004825-cdvnqfjz 47 60 presence presence NN cord-004825-cdvnqfjz 47 61 or or CC cord-004825-cdvnqfjz 47 62 in in IN cord-004825-cdvnqfjz 47 63 the the DT cord-004825-cdvnqfjz 47 64 absence absence NN cord-004825-cdvnqfjz 47 65 of of IN cord-004825-cdvnqfjz 47 66 15 15 CD cord-004825-cdvnqfjz 47 67 mM mm CD cord-004825-cdvnqfjz 47 68 ammonium ammonium NN cord-004825-cdvnqfjz 47 69 chloride chloride NN cord-004825-cdvnqfjz 47 70 . . . cord-004825-cdvnqfjz 48 1 After after IN cord-004825-cdvnqfjz 48 2 3 3 CD cord-004825-cdvnqfjz 48 3 h h NN cord-004825-cdvnqfjz 48 4 of of IN cord-004825-cdvnqfjz 48 5 incubation incubation NN cord-004825-cdvnqfjz 48 6 at at IN cord-004825-cdvnqfjz 48 7 37 37 CD cord-004825-cdvnqfjz 48 8 ° ° NN cord-004825-cdvnqfjz 48 9 C c NN cord-004825-cdvnqfjz 48 10 , , , cord-004825-cdvnqfjz 48 11 cells cell NNS cord-004825-cdvnqfjz 48 12 were be VBD cord-004825-cdvnqfjz 48 13 washed wash VBN cord-004825-cdvnqfjz 48 14 twice twice RB cord-004825-cdvnqfjz 48 15 with with IN cord-004825-cdvnqfjz 48 16 PBS PBS NNP cord-004825-cdvnqfjz 48 17 and and CC cord-004825-cdvnqfjz 48 18 MEM MEM NNP cord-004825-cdvnqfjz 48 19 containing contain VBG cord-004825-cdvnqfjz 48 20 0.7~ 0.7~ CD cord-004825-cdvnqfjz 48 21 methylcellulose methylcellulose NN cord-004825-cdvnqfjz 48 22 , , , cord-004825-cdvnqfjz 48 23 pH pH NNP cord-004825-cdvnqfjz 48 24 7.5 7.5 CD cord-004825-cdvnqfjz 48 25 , , , cord-004825-cdvnqfjz 48 26 was be VBD cord-004825-cdvnqfjz 48 27 added add VBN cord-004825-cdvnqfjz 48 28 . . . cord-004825-cdvnqfjz 49 1 In in IN cord-004825-cdvnqfjz 49 2 other other JJ cord-004825-cdvnqfjz 49 3 set set NN cord-004825-cdvnqfjz 49 4 of of IN cord-004825-cdvnqfjz 49 5 cultures culture NNS cord-004825-cdvnqfjz 49 6 , , , cord-004825-cdvnqfjz 49 7 after after IN cord-004825-cdvnqfjz 49 8 adsorption adsorption NN cord-004825-cdvnqfjz 49 9 cells cell NNS cord-004825-cdvnqfjz 49 10 were be VBD cord-004825-cdvnqfjz 49 11 washed wash VBN cord-004825-cdvnqfjz 49 12 with with IN cord-004825-cdvnqfjz 49 13 PBS PBS NNP cord-004825-cdvnqfjz 49 14 and and CC cord-004825-cdvnqfjz 49 15 incubated incubate VBN cord-004825-cdvnqfjz 49 16 at at IN cord-004825-cdvnqfjz 49 17 37 37 CD cord-004825-cdvnqfjz 49 18 ° ° NN cord-004825-cdvnqfjz 49 19 C c NN cord-004825-cdvnqfjz 49 20 for for IN cord-004825-cdvnqfjz 49 21 2 2 CD cord-004825-cdvnqfjz 49 22 rain rain NN cord-004825-cdvnqfjz 49 23 in in IN cord-004825-cdvnqfjz 49 24 MEM mem NN cord-004825-cdvnqfjz 49 25 buffered buffer VBN cord-004825-cdvnqfjz 49 26 at at IN cord-004825-cdvnqfjz 49 27 different different JJ cord-004825-cdvnqfjz 49 28 pH ph NN cord-004825-cdvnqfjz 49 29 as as IN cord-004825-cdvnqfjz 49 30 indicated indicate VBN cord-004825-cdvnqfjz 49 31 above above RB cord-004825-cdvnqfjz 49 32 . . . cord-004825-cdvnqfjz 50 1 Then then RB cord-004825-cdvnqfjz 50 2 , , , cord-004825-cdvnqfjz 50 3 cells cell NNS cord-004825-cdvnqfjz 50 4 were be VBD cord-004825-cdvnqfjz 50 5 washed wash VBN cord-004825-cdvnqfjz 50 6 with with IN cord-004825-cdvnqfjz 50 7 PBS PBS NNP cord-004825-cdvnqfjz 50 8 and and CC cord-004825-cdvnqfjz 50 9 MEM MEM NNP cord-004825-cdvnqfjz 50 10 at at IN cord-004825-cdvnqfjz 50 11 pH pH NNP cord-004825-cdvnqfjz 50 12 7.5 7.5 CD cord-004825-cdvnqfjz 50 13 containing contain VBG cord-004825-cdvnqfjz 50 14 or or CC cord-004825-cdvnqfjz 50 15 not not RB cord-004825-cdvnqfjz 50 16 15raM 15ram CD cord-004825-cdvnqfjz 50 17 ammonium ammonium NN cord-004825-cdvnqfjz 50 18 chloride chloride NN cord-004825-cdvnqfjz 50 19 was be VBD cord-004825-cdvnqfjz 50 20 added add VBN cord-004825-cdvnqfjz 50 21 . . . cord-004825-cdvnqfjz 51 1 After after IN cord-004825-cdvnqfjz 51 2 3h 3h CD cord-004825-cdvnqfjz 51 3 of of IN cord-004825-cdvnqfjz 51 4 incubation incubation NN cord-004825-cdvnqfjz 51 5 cultures culture NNS cord-004825-cdvnqfjz 51 6 were be VBD cord-004825-cdvnqfjz 51 7 overlaid overlay VBN cord-004825-cdvnqfjz 51 8 with with IN cord-004825-cdvnqfjz 51 9 methylcetlulose methylcetlulose NNS cord-004825-cdvnqfjz 51 10 as as IN cord-004825-cdvnqfjz 51 11 above above RB cord-004825-cdvnqfjz 51 12 . . . cord-004825-cdvnqfjz 52 1 In in IN cord-004825-cdvnqfjz 52 2 both both DT cord-004825-cdvnqfjz 52 3 set set NN cord-004825-cdvnqfjz 52 4 of of IN cord-004825-cdvnqfjz 52 5 cultures culture NNS cord-004825-cdvnqfjz 52 6 plaques plaque NNS cord-004825-cdvnqfjz 52 7 were be VBD cord-004825-cdvnqfjz 52 8 counted count VBN cord-004825-cdvnqfjz 52 9 after after IN cord-004825-cdvnqfjz 52 10 7 7 CD cord-004825-cdvnqfjz 52 11 days day NNS cord-004825-cdvnqfjz 52 12 of of IN cord-004825-cdvnqfjz 52 13 incubation incubation NN cord-004825-cdvnqfjz 52 14 and and CC cord-004825-cdvnqfjz 52 15 percent percent NN cord-004825-cdvnqfjz 52 16 of of IN cord-004825-cdvnqfjz 52 17 inhibition inhibition NN cord-004825-cdvnqfjz 52 18 was be VBD cord-004825-cdvnqfjz 52 19 calculated calculate VBN cord-004825-cdvnqfjz 52 20 . . . cord-004825-cdvnqfjz 53 1 Vero Vero NNP cord-004825-cdvnqfjz 53 2 cells cell NNS cord-004825-cdvnqfjz 53 3 were be VBD cord-004825-cdvnqfjz 53 4 infected infect VBN cord-004825-cdvnqfjz 53 5 with with IN cord-004825-cdvnqfjz 53 6 JV JV NNP cord-004825-cdvnqfjz 53 7 at at IN cord-004825-cdvnqfjz 53 8 a a DT cord-004825-cdvnqfjz 53 9 moi moi NN cord-004825-cdvnqfjz 53 10 of of IN cord-004825-cdvnqfjz 53 11 1 1 CD cord-004825-cdvnqfjz 53 12 . . . cord-004825-cdvnqfjz 54 1 At at IN cord-004825-cdvnqfjz 54 2 48 48 CD cord-004825-cdvnqfjz 54 3 h h NN cord-004825-cdvnqfjz 54 4 after after IN cord-004825-cdvnqfjz 54 5 infection infection NN cord-004825-cdvnqfjz 54 6 , , , cord-004825-cdvnqfjz 54 7 medium medium NN cord-004825-cdvnqfjz 54 8 was be VBD cord-004825-cdvnqfjz 54 9 removed remove VBN cord-004825-cdvnqfjz 54 10 and and CC cord-004825-cdvnqfjz 54 11 cells cell NNS cord-004825-cdvnqfjz 54 12 were be VBD cord-004825-cdvnqfjz 54 13 incubated incubate VBN cord-004825-cdvnqfjz 54 14 in in IN cord-004825-cdvnqfjz 54 15 MEM MEM NNP cord-004825-cdvnqfjz 54 16 buffered buffer VBN cord-004825-cdvnqfjz 54 17 at at IN cord-004825-cdvnqfjz 54 18 pH pH NNP cord-004825-cdvnqfjz 54 19 5.5 5.5 CD cord-004825-cdvnqfjz 54 20 or or CC cord-004825-cdvnqfjz 54 21 7.5 7.5 CD cord-004825-cdvnqfjz 54 22 as as IN cord-004825-cdvnqfjz 54 23 indicated indicate VBN cord-004825-cdvnqfjz 54 24 above above RB cord-004825-cdvnqfjz 54 25 . . . cord-004825-cdvnqfjz 55 1 Then then RB cord-004825-cdvnqfjz 55 2 , , , cord-004825-cdvnqfjz 55 3 monolayers monolayer NNS cord-004825-cdvnqfjz 55 4 were be VBD cord-004825-cdvnqfjz 55 5 stained stain VBN cord-004825-cdvnqfjz 55 6 with with IN cord-004825-cdvnqfjz 55 7 Giemsa Giemsa NNP cord-004825-cdvnqfjz 55 8 and and CC cord-004825-cdvnqfjz 55 9 syncytia syncytia NN cord-004825-cdvnqfjz 55 10 containing contain VBG cord-004825-cdvnqfjz 55 11 more more JJR cord-004825-cdvnqfjz 55 12 than than IN cord-004825-cdvnqfjz 55 13 10 10 CD cord-004825-cdvnqfjz 55 14 nuclei nucleus NNS cord-004825-cdvnqfjz 55 15 were be VBD cord-004825-cdvnqfjz 55 16 counted count VBN cord-004825-cdvnqfjz 55 17 . . . cord-004825-cdvnqfjz 55 18 _SP cord-004825-cdvnqfjz 56 1 To to TO cord-004825-cdvnqfjz 56 2 determine determine VB cord-004825-cdvnqfjz 56 3 the the DT cord-004825-cdvnqfjz 56 4 time time NN cord-004825-cdvnqfjz 56 5 at at IN cord-004825-cdvnqfjz 56 6 which which WDT cord-004825-cdvnqfjz 56 7 lysosomotropic lysosomotropic JJ cord-004825-cdvnqfjz 56 8 agents agent NNS cord-004825-cdvnqfjz 56 9 caused cause VBD cord-004825-cdvnqfjz 56 10 their -PRON- PRP$ cord-004825-cdvnqfjz 56 11 inhibitory inhibitory JJ cord-004825-cdvnqfjz 56 12 action action NN cord-004825-cdvnqfjz 56 13 , , , cord-004825-cdvnqfjz 56 14 we -PRON- PRP cord-004825-cdvnqfjz 56 15 next next RB cord-004825-cdvnqfjz 56 16 examined examine VBD cord-004825-cdvnqfjz 56 17 the the DT cord-004825-cdvnqfjz 56 18 effect effect NN cord-004825-cdvnqfjz 56 19 of of IN cord-004825-cdvnqfjz 56 20 the the DT cord-004825-cdvnqfjz 56 21 time time NN cord-004825-cdvnqfjz 56 22 of of IN cord-004825-cdvnqfjz 56 23 addition addition NN cord-004825-cdvnqfjz 56 24 of of IN cord-004825-cdvnqfjz 56 25 15 15 CD cord-004825-cdvnqfjz 56 26 mM mm CD cord-004825-cdvnqfjz 56 27 ammonium ammonium NN cord-004825-cdvnqfjz 56 28 chloride chloride NN cord-004825-cdvnqfjz 56 29 on on IN cord-004825-cdvnqfjz 56 30 extracellular extracellular JJ cord-004825-cdvnqfjz 56 31 virus virus NN cord-004825-cdvnqfjz 56 32 yields yield NNS cord-004825-cdvnqfjz 56 33 . . . cord-004825-cdvnqfjz 57 1 A a DT cord-004825-cdvnqfjz 57 2 nearly nearly RB cord-004825-cdvnqfjz 57 3 complete complete JJ cord-004825-cdvnqfjz 57 4 inhibition inhibition NN cord-004825-cdvnqfjz 57 5 of of IN cord-004825-cdvnqfjz 57 6 viral viral JJ cord-004825-cdvnqfjz 57 7 multiplication multiplication NN cord-004825-cdvnqfjz 57 8 was be VBD cord-004825-cdvnqfjz 57 9 observed observe VBN cord-004825-cdvnqfjz 57 10 when when WRB cord-004825-cdvnqfjz 57 11 the the DT cord-004825-cdvnqfjz 57 12 compound compound NN cord-004825-cdvnqfjz 57 13 was be VBD cord-004825-cdvnqfjz 57 14 added add VBN cord-004825-cdvnqfjz 57 15 one one CD cord-004825-cdvnqfjz 57 16 hour hour NN cord-004825-cdvnqfjz 57 17 before before RB cord-004825-cdvnqfjz 57 18 or or CC cord-004825-cdvnqfjz 57 19 simultaneously simultaneously RB cord-004825-cdvnqfjz 57 20 with with IN cord-004825-cdvnqfjz 57 21 virus virus NN cord-004825-cdvnqfjz 57 22 infection infection NN cord-004825-cdvnqfjz 57 23 and and CC cord-004825-cdvnqfjz 57 24 maintained maintain VBN cord-004825-cdvnqfjz 57 25 during during IN cord-004825-cdvnqfjz 57 26 all all PDT cord-004825-cdvnqfjz 57 27 the the DT cord-004825-cdvnqfjz 57 28 period period NN cord-004825-cdvnqfjz 57 29 of of IN cord-004825-cdvnqfjz 57 30 incubation incubation NN cord-004825-cdvnqfjz 57 31 ( ( -LRB- cord-004825-cdvnqfjz 57 32 Fig Fig NNP cord-004825-cdvnqfjz 57 33 . . NNP cord-004825-cdvnqfjz 57 34 2 2 CD cord-004825-cdvnqfjz 57 35 ) ) -RRB- cord-004825-cdvnqfjz 57 36 . . . cord-004825-cdvnqfjz 58 1 When when WRB cord-004825-cdvnqfjz 58 2 time time NN cord-004825-cdvnqfjz 58 3 of of IN cord-004825-cdvnqfjz 58 4 drug drug NN cord-004825-cdvnqfjz 58 5 addition addition NN cord-004825-cdvnqfjz 58 6 was be VBD cord-004825-cdvnqfjz 58 7 delayed delay VBN cord-004825-cdvnqfjz 58 8 , , , cord-004825-cdvnqfjz 58 9 virus virus NN cord-004825-cdvnqfjz 58 10 production production NN cord-004825-cdvnqfjz 58 11 progressively progressively RB cord-004825-cdvnqfjz 58 12 increased increase VBD cord-004825-cdvnqfjz 58 13 , , , cord-004825-cdvnqfjz 58 14 indicating indicate VBG cord-004825-cdvnqfjz 58 15 that that IN cord-004825-cdvnqfjz 58 16 ammonium ammonium NN cord-004825-cdvnqfjz 58 17 chloride chloride NN cord-004825-cdvnqfjz 58 18 inhibited inhibit VBD cord-004825-cdvnqfjz 58 19 an an DT cord-004825-cdvnqfjz 58 20 early early JJ cord-004825-cdvnqfjz 58 21 step step NN cord-004825-cdvnqfjz 58 22 of of IN cord-004825-cdvnqfjz 58 23 the the DT cord-004825-cdvnqfjz 58 24 replicative replicative JJ cord-004825-cdvnqfjz 58 25 cycle cycle NN cord-004825-cdvnqfjz 58 26 . . . cord-004825-cdvnqfjz 59 1 In in IN cord-004825-cdvnqfjz 59 2 fact fact NN cord-004825-cdvnqfjz 59 3 , , , cord-004825-cdvnqfjz 59 4 no no DT cord-004825-cdvnqfjz 59 5 significant significant JJ cord-004825-cdvnqfjz 59 6 differences difference NNS cord-004825-cdvnqfjz 59 7 were be VBD cord-004825-cdvnqfjz 59 8 found find VBN cord-004825-cdvnqfjz 59 9 when when WRB cord-004825-cdvnqfjz 59 10 the the DT cord-004825-cdvnqfjz 59 11 drug drug NN cord-004825-cdvnqfjz 59 12 was be VBD cord-004825-cdvnqfjz 59 13 added add VBN cord-004825-cdvnqfjz 59 14 between between IN cord-004825-cdvnqfjz 59 15 5 5 CD cord-004825-cdvnqfjz 59 16 and and CC cord-004825-cdvnqfjz 59 17 8 8 CD cord-004825-cdvnqfjz 59 18 h h NN cord-004825-cdvnqfjz 59 19 p.i p.i NNP cord-004825-cdvnqfjz 59 20 . . . cord-004825-cdvnqfjz 60 1 Since since IN cord-004825-cdvnqfjz 60 2 maximum maximum JJ cord-004825-cdvnqfjz 60 3 inhibition inhibition NN cord-004825-cdvnqfjz 60 4 in in IN cord-004825-cdvnqfjz 60 5 JV JV NNP cord-004825-cdvnqfjz 60 6 multiplication multiplication NN cord-004825-cdvnqfjz 60 7 was be VBD cord-004825-cdvnqfjz 60 8 obtained obtain VBN cord-004825-cdvnqfjz 60 9 when when WRB cord-004825-cdvnqfjz 60 10 the the DT cord-004825-cdvnqfjz 60 11 drug drug NN cord-004825-cdvnqfjz 60 12 was be VBD cord-004825-cdvnqfjz 60 13 present present JJ cord-004825-cdvnqfjz 60 14 during during IN cord-004825-cdvnqfjz 60 15 the the DT cord-004825-cdvnqfjz 60 16 first first JJ cord-004825-cdvnqfjz 60 17 hour hour NN cord-004825-cdvnqfjz 60 18 after after IN cord-004825-cdvnqfjz 60 19 infection infection NN cord-004825-cdvnqfjz 60 20 , , , cord-004825-cdvnqfjz 60 21 we -PRON- PRP cord-004825-cdvnqfjz 60 22 examined examine VBD cord-004825-cdvnqfjz 60 23 its -PRON- PRP$ cord-004825-cdvnqfjz 60 24 effect effect NN cord-004825-cdvnqfjz 60 25 on on IN cord-004825-cdvnqfjz 60 26 the the DT cord-004825-cdvnqfjz 60 27 early early JJ cord-004825-cdvnqfjz 60 28 stages stage NNS cord-004825-cdvnqfjz 60 29 of of IN cord-004825-cdvnqfjz 60 30 replication replication NN cord-004825-cdvnqfjz 60 31 . . . cord-004825-cdvnqfjz 61 1 As as IN cord-004825-cdvnqfjz 61 2 shown show VBN cord-004825-cdvnqfjz 61 3 in in IN cord-004825-cdvnqfjz 61 4 Table Table NNP cord-004825-cdvnqfjz 61 5 1 1 CD cord-004825-cdvnqfjz 61 6 , , , cord-004825-cdvnqfjz 61 7 ammonium ammonium NN cord-004825-cdvnqfjz 61 8 chloride chloride NN cord-004825-cdvnqfjz 61 9 had have VBD cord-004825-cdvnqfjz 61 10 no no DT cord-004825-cdvnqfjz 61 11 effect effect NN cord-004825-cdvnqfjz 61 12 on on IN cord-004825-cdvnqfjz 61 13 JV JV NNP cord-004825-cdvnqfjz 61 14 adsorption adsorption NN cord-004825-cdvnqfjz 61 15 since since IN cord-004825-cdvnqfjz 61 16 the the DT cord-004825-cdvnqfjz 61 17 titers titer NNS cord-004825-cdvnqfjz 61 18 of of IN cord-004825-cdvnqfjz 61 19 virus virus NN cord-004825-cdvnqfjz 61 20 adsorbed adsorb VBN cord-004825-cdvnqfjz 61 21 at at IN cord-004825-cdvnqfjz 61 22 4 4 CD cord-004825-cdvnqfjz 61 23 ° ° NN cord-004825-cdvnqfjz 61 24 C c NN cord-004825-cdvnqfjz 61 25 in in IN cord-004825-cdvnqfjz 61 26 treated treat VBN cord-004825-cdvnqfjz 61 27 and and CC cord-004825-cdvnqfjz 61 28 untreated untreated JJ cord-004825-cdvnqfjz 61 29 cells cell NNS cord-004825-cdvnqfjz 61 30 did do VBD cord-004825-cdvnqfjz 61 31 not not RB cord-004825-cdvnqfjz 61 32 differ differ VB cord-004825-cdvnqfjz 61 33 significantly significantly RB cord-004825-cdvnqfjz 61 34 . . . cord-004825-cdvnqfjz 62 1 In in IN cord-004825-cdvnqfjz 62 2 both both DT cord-004825-cdvnqfjz 62 3 cases case NNS cord-004825-cdvnqfjz 62 4 , , , cord-004825-cdvnqfjz 62 5 virus virus NN cord-004825-cdvnqfjz 62 6 adsorption adsorption NN cord-004825-cdvnqfjz 62 7 occurred occur VBD cord-004825-cdvnqfjz 62 8 rapidly rapidly RB cord-004825-cdvnqfjz 62 9 and and CC cord-004825-cdvnqfjz 62 10 the the DT cord-004825-cdvnqfjz 62 11 percentage percentage NN cord-004825-cdvnqfjz 62 12 of of IN cord-004825-cdvnqfjz 62 13 adsorbed adsorb VBN cord-004825-cdvnqfjz 62 14 virus virus NN cord-004825-cdvnqfjz 62 15 was be VBD cord-004825-cdvnqfjz 62 16 approximately approximately RB cord-004825-cdvnqfjz 62 17 5 5 CD cord-004825-cdvnqfjz 62 18 % % NN cord-004825-cdvnqfjz 62 19 . . . cord-004825-cdvnqfjz 63 1 To to TO cord-004825-cdvnqfjz 63 2 investigate investigate VB cord-004825-cdvnqfjz 63 3 whether whether IN cord-004825-cdvnqfjz 63 4 ammonium ammonium NN cord-004825-cdvnqfjz 63 5 chloride chloride NN cord-004825-cdvnqfjz 63 6 affects affect VBZ cord-004825-cdvnqfjz 63 7 JV JV NNP cord-004825-cdvnqfjz 63 8 internalization internalization NN cord-004825-cdvnqfjz 63 9 , , , cord-004825-cdvnqfjz 63 10 virus virus NN cord-004825-cdvnqfjz 63 11 adsorbed adsorb VBN cord-004825-cdvnqfjz 63 12 cells cell NNS cord-004825-cdvnqfjz 63 13 at at IN cord-004825-cdvnqfjz 63 14 4 4 CD cord-004825-cdvnqfjz 63 15 ° ° NN cord-004825-cdvnqfjz 63 16 C C NNP cord-004825-cdvnqfjz 63 17 were be VBD cord-004825-cdvnqfjz 63 18 warmed warm VBN cord-004825-cdvnqfjz 63 19 to to IN cord-004825-cdvnqfjz 63 20 37 37 CD cord-004825-cdvnqfjz 63 21 ~C ~C NFP cord-004825-cdvnqfjz 63 22 for for IN cord-004825-cdvnqfjz 63 23 various various JJ cord-004825-cdvnqfjz 63 24 intervals interval NNS cord-004825-cdvnqfjz 63 25 in in IN cord-004825-cdvnqfjz 63 26 presence presence NN cord-004825-cdvnqfjz 63 27 or or CC cord-004825-cdvnqfjz 63 28 absence absence NN cord-004825-cdvnqfjz 63 29 of of IN cord-004825-cdvnqfjz 63 30 the the DT cord-004825-cdvnqfjz 63 31 compound compound NN cord-004825-cdvnqfjz 63 32 and and CC cord-004825-cdvnqfjz 63 33 internalized internalize VBN cord-004825-cdvnqfjz 63 34 virus virus NN cord-004825-cdvnqfjz 63 35 was be VBD cord-004825-cdvnqfjz 63 36 determined determine VBN cord-004825-cdvnqfjz 63 37 by by IN cord-004825-cdvnqfjz 63 38 infectious infectious JJ cord-004825-cdvnqfjz 63 39 center center NN cord-004825-cdvnqfjz 63 40 assay assay NN cord-004825-cdvnqfjz 63 41 . . . cord-004825-cdvnqfjz 64 1 The the DT cord-004825-cdvnqfjz 64 2 amount amount NN cord-004825-cdvnqfjz 64 3 of of IN cord-004825-cdvnqfjz 64 4 JV JV NNP cord-004825-cdvnqfjz 64 5 internalized internalize VBD cord-004825-cdvnqfjz 64 6 virus virus NN cord-004825-cdvnqfjz 64 7 in in IN cord-004825-cdvnqfjz 64 8 untreated untreated JJ cord-004825-cdvnqfjz 64 9 cells cell NNS cord-004825-cdvnqfjz 64 10 sharply sharply RB cord-004825-cdvnqfjz 64 11 increased increase VBD cord-004825-cdvnqfjz 64 12 after after IN cord-004825-cdvnqfjz 64 13 30 30 CD cord-004825-cdvnqfjz 64 14 min min NN cord-004825-cdvnqfjz 64 15 of of IN cord-004825-cdvnqfjz 64 16 incubation incubation NN cord-004825-cdvnqfjz 64 17 at at IN cord-004825-cdvnqfjz 64 18 37 37 CD cord-004825-cdvnqfjz 64 19 ° ° NN cord-004825-cdvnqfjz 64 20 C c NN cord-004825-cdvnqfjz 64 21 and and CC cord-004825-cdvnqfjz 64 22 the the DT cord-004825-cdvnqfjz 64 23 uptake uptake NN cord-004825-cdvnqfjz 64 24 was be VBD cord-004825-cdvnqfjz 64 25 apparently apparently RB cord-004825-cdvnqfjz 64 26 complete complete JJ cord-004825-cdvnqfjz 64 27 after after IN cord-004825-cdvnqfjz 64 28 1.5 1.5 CD cord-004825-cdvnqfjz 64 29 h h NN cord-004825-cdvnqfjz 64 30 ( ( -LRB- cord-004825-cdvnqfjz 64 31 Fig Fig NNP cord-004825-cdvnqfjz 64 32 . . . cord-004825-cdvnqfjz 64 33 3 3 CD cord-004825-cdvnqfjz 64 34 ) ) -RRB- cord-004825-cdvnqfjz 64 35 . . . cord-004825-cdvnqfjz 65 1 In in IN cord-004825-cdvnqfjz 65 2 the the DT cord-004825-cdvnqfjz 65 3 presence presence NN cord-004825-cdvnqfjz 65 4 of of IN cord-004825-cdvnqfjz 65 5 ammonium ammonium NN cord-004825-cdvnqfjz 65 6 chloride chloride NN cord-004825-cdvnqfjz 65 7 there there EX cord-004825-cdvnqfjz 65 8 was be VBD cord-004825-cdvnqfjz 65 9 no no DT cord-004825-cdvnqfjz 65 10 virus virus NN cord-004825-cdvnqfjz 65 11 internalization internalization NN cord-004825-cdvnqfjz 65 12 and and CC cord-004825-cdvnqfjz 65 13 a a DT cord-004825-cdvnqfjz 65 14 progressive progressive JJ cord-004825-cdvnqfjz 65 15 decrease decrease NN cord-004825-cdvnqfjz 65 16 is be VBZ cord-004825-cdvnqfjz 65 17 observed observe VBN cord-004825-cdvnqfjz 65 18 in in IN cord-004825-cdvnqfjz 65 19 the the DT cord-004825-cdvnqfjz 65 20 number number NN cord-004825-cdvnqfjz 65 21 of of IN cord-004825-cdvnqfjz 65 22 infectious infectious JJ cord-004825-cdvnqfjz 65 23 centers center NNS cord-004825-cdvnqfjz 65 24 . . . cord-004825-cdvnqfjz 66 1 The the DT cord-004825-cdvnqfjz 66 2 relatively relatively RB cord-004825-cdvnqfjz 66 3 small small JJ cord-004825-cdvnqfjz 66 4 difference difference NN cord-004825-cdvnqfjz 66 5 between between IN cord-004825-cdvnqfjz 66 6 the the DT cord-004825-cdvnqfjz 66 7 control control NN cord-004825-cdvnqfjz 66 8 and and CC cord-004825-cdvnqfjz 66 9 treated treat VBN cord-004825-cdvnqfjz 66 10 cells cell NNS cord-004825-cdvnqfjz 66 11 at at IN cord-004825-cdvnqfjz 66 12 the the DT cord-004825-cdvnqfjz 66 13 30min 30min NNP cord-004825-cdvnqfjz 66 14 time time NN cord-004825-cdvnqfjz 66 15 point point NN cord-004825-cdvnqfjz 66 16 might may MD cord-004825-cdvnqfjz 66 17 reflect reflect VB cord-004825-cdvnqfjz 66 18 the the DT cord-004825-cdvnqfjz 66 19 fact fact NN cord-004825-cdvnqfjz 66 20 that that IN cord-004825-cdvnqfjz 66 21 part part NN cord-004825-cdvnqfjz 66 22 of of IN cord-004825-cdvnqfjz 66 23 the the DT cord-004825-cdvnqfjz 66 24 adsorbed adsorb VBN cord-004825-cdvnqfjz 66 25 virus virus NN cord-004825-cdvnqfjz 66 26 was be VBD cord-004825-cdvnqfjz 66 27 not not RB cord-004825-cdvnqfjz 66 28 removed remove VBN cord-004825-cdvnqfjz 66 29 by by IN cord-004825-cdvnqfjz 66 30 the the DT cord-004825-cdvnqfjz 66 31 proteinase proteinase NN cord-004825-cdvnqfjz 66 32 K K NNP cord-004825-cdvnqfjz 66 33 treatment treatment NN cord-004825-cdvnqfjz 66 34 . . . cord-004825-cdvnqfjz 67 1 The the DT cord-004825-cdvnqfjz 67 2 action action NN cord-004825-cdvnqfjz 67 3 of of IN cord-004825-cdvnqfjz 67 4 weak weak JJ cord-004825-cdvnqfjz 67 5 bases basis NNS cord-004825-cdvnqfjz 67 6 on on IN cord-004825-cdvnqfjz 67 7 JV JV NNP cord-004825-cdvnqfjz 67 8 replication replication NN cord-004825-cdvnqfjz 67 9 was be VBD cord-004825-cdvnqfjz 67 10 confirmed confirm VBN cord-004825-cdvnqfjz 67 11 by by IN cord-004825-cdvnqfjz 67 12 measuring measure VBG cord-004825-cdvnqfjz 67 13 viral viral JJ cord-004825-cdvnqfjz 67 14 protein protein NN cord-004825-cdvnqfjz 67 15 production production NN cord-004825-cdvnqfjz 67 16 in in IN cord-004825-cdvnqfjz 67 17 infected infected JJ cord-004825-cdvnqfjz 67 18 cells cell NNS cord-004825-cdvnqfjz 67 19 by by IN cord-004825-cdvnqfjz 67 20 an an DT cord-004825-cdvnqfjz 67 21 immunofluorescence immunofluorescence NN cord-004825-cdvnqfjz 67 22 assay assay NN cord-004825-cdvnqfjz 67 23 . . . cord-004825-cdvnqfjz 68 1 The the DT cord-004825-cdvnqfjz 68 2 inhibition inhibition NN cord-004825-cdvnqfjz 68 3 in in IN cord-004825-cdvnqfjz 68 4 the the DT cord-004825-cdvnqfjz 68 5 number number NN cord-004825-cdvnqfjz 68 6 of of IN cord-004825-cdvnqfjz 68 7 fluorescent fluorescent JJ cord-004825-cdvnqfjz 68 8 cells cell NNS cord-004825-cdvnqfjz 68 9 in in IN cord-004825-cdvnqfjz 68 10 the the DT cord-004825-cdvnqfjz 68 11 presence presence NN cord-004825-cdvnqfjz 68 12 of of IN cord-004825-cdvnqfjz 68 13 15mM 15mm CD cord-004825-cdvnqfjz 68 14 ammonium ammonium NN cord-004825-cdvnqfjz 68 15 chloride chloride NN cord-004825-cdvnqfjz 68 16 was be VBD cord-004825-cdvnqfjz 68 17 98.8 98.8 CD cord-004825-cdvnqfjz 68 18 % % NN cord-004825-cdvnqfjz 68 19 ( ( -LRB- cord-004825-cdvnqfjz 68 20 Fig Fig NNP cord-004825-cdvnqfjz 68 21 . . . cord-004825-cdvnqfjz 68 22 4 4 CD cord-004825-cdvnqfjz 68 23 ) ) -RRB- cord-004825-cdvnqfjz 68 24 . . . cord-004825-cdvnqfjz 69 1 The the DT cord-004825-cdvnqfjz 69 2 other other JJ cord-004825-cdvnqfjz 69 3 lysosomotropic lysosomotropic JJ cord-004825-cdvnqfjz 69 4 compounds compound NNS cord-004825-cdvnqfjz 69 5 also also RB cord-004825-cdvnqfjz 69 6 inhibited inhibit VBD cord-004825-cdvnqfjz 69 7 viral viral JJ cord-004825-cdvnqfjz 69 8 antigen antigen NN cord-004825-cdvnqfjz 69 9 expression expression NN cord-004825-cdvnqfjz 69 10 ( ( -LRB- cord-004825-cdvnqfjz 69 11 data datum NNS cord-004825-cdvnqfjz 69 12 not not RB cord-004825-cdvnqfjz 69 13 shown show VBN cord-004825-cdvnqfjz 69 14 ) ) -RRB- cord-004825-cdvnqfjz 69 15 . . . cord-004825-cdvnqfjz 70 1 In in IN cord-004825-cdvnqfjz 70 2 an an DT cord-004825-cdvnqfjz 70 3 effort effort NN cord-004825-cdvnqfjz 70 4 to to TO cord-004825-cdvnqfjz 70 5 demonstrate demonstrate VB cord-004825-cdvnqfjz 70 6 that that IN cord-004825-cdvnqfjz 70 7 the the DT cord-004825-cdvnqfjz 70 8 entry entry NN cord-004825-cdvnqfjz 70 9 of of IN cord-004825-cdvnqfjz 70 10 JV JV NNP cord-004825-cdvnqfjz 70 11 into into IN cord-004825-cdvnqfjz 70 12 Vero Vero NNP cord-004825-cdvnqfjz 70 13 cells cell NNS cord-004825-cdvnqfjz 70 14 is be VBZ cord-004825-cdvnqfjz 70 15 an an DT cord-004825-cdvnqfjz 70 16 acid acid NN cord-004825-cdvnqfjz 70 17 pH ph NN cord-004825-cdvnqfjz 70 18 - - HYPH cord-004825-cdvnqfjz 70 19 dependent dependent JJ cord-004825-cdvnqfjz 70 20 process process NN cord-004825-cdvnqfjz 70 21 , , , cord-004825-cdvnqfjz 70 22 we -PRON- PRP cord-004825-cdvnqfjz 70 23 have have VBP cord-004825-cdvnqfjz 70 24 finally finally RB cord-004825-cdvnqfjz 70 25 studied study VBN cord-004825-cdvnqfjz 70 26 the the DT cord-004825-cdvnqfjz 70 27 effect effect NN cord-004825-cdvnqfjz 70 28 of of IN cord-004825-cdvnqfjz 70 29 different different JJ cord-004825-cdvnqfjz 70 30 pH ph NN cord-004825-cdvnqfjz 70 31 values value NNS cord-004825-cdvnqfjz 70 32 on on IN cord-004825-cdvnqfjz 70 33 the the DT cord-004825-cdvnqfjz 70 34 internalization internalization NN cord-004825-cdvnqfjz 70 35 of of IN cord-004825-cdvnqfjz 70 36 JV JV NNP cord-004825-cdvnqfjz 70 37 particles particle NNS cord-004825-cdvnqfjz 70 38 that that WDT cord-004825-cdvnqfjz 70 39 have have VBP cord-004825-cdvnqfjz 70 40 been be VBN cord-004825-cdvnqfjz 70 41 prebound prebound VBN cord-004825-cdvnqfjz 70 42 to to IN cord-004825-cdvnqfjz 70 43 Vero Vero NNP cord-004825-cdvnqfjz 70 44 cells cell NNS cord-004825-cdvnqfjz 70 45 . . . cord-004825-cdvnqfjz 71 1 In in IN cord-004825-cdvnqfjz 71 2 the the DT cord-004825-cdvnqfjz 71 3 absence absence NN cord-004825-cdvnqfjz 71 4 of of IN cord-004825-cdvnqfjz 71 5 ammonium ammonium NN cord-004825-cdvnqfjz 71 6 chloride chloride NN cord-004825-cdvnqfjz 71 7 , , , cord-004825-cdvnqfjz 71 8 infectivity infectivity NN cord-004825-cdvnqfjz 71 9 of of IN cord-004825-cdvnqfjz 71 10 JV JV NNP cord-004825-cdvnqfjz 71 11 was be VBD cord-004825-cdvnqfjz 71 12 not not RB cord-004825-cdvnqfjz 71 13 affected affect VBN cord-004825-cdvnqfjz 71 14 at at IN cord-004825-cdvnqfjz 71 15 the the DT cord-004825-cdvnqfjz 71 16 pH pH NNP cord-004825-cdvnqfjz 71 17 range range NN cord-004825-cdvnqfjz 71 18 assayed assay VBN cord-004825-cdvnqfjz 71 19 ( ( -LRB- cord-004825-cdvnqfjz 71 20 5.5 5.5 CD cord-004825-cdvnqfjz 71 21 - - SYM cord-004825-cdvnqfjz 71 22 7.5 7.5 CD cord-004825-cdvnqfjz 71 23 ) ) -RRB- cord-004825-cdvnqfjz 71 24 ( ( -LRB- cord-004825-cdvnqfjz 71 25 data datum NNS cord-004825-cdvnqfjz 71 26 not not RB cord-004825-cdvnqfjz 71 27 shown show VBN cord-004825-cdvnqfjz 71 28 ) ) -RRB- cord-004825-cdvnqfjz 71 29 . . . cord-004825-cdvnqfjz 72 1 A a DT cord-004825-cdvnqfjz 72 2 high high JJ cord-004825-cdvnqfjz 72 3 degree degree NN cord-004825-cdvnqfjz 72 4 of of IN cord-004825-cdvnqfjz 72 5 inhibition inhibition NN cord-004825-cdvnqfjz 72 6 was be VBD cord-004825-cdvnqfjz 72 7 observed observe VBN cord-004825-cdvnqfjz 72 8 when when WRB cord-004825-cdvnqfjz 72 9 cultures culture NNS cord-004825-cdvnqfjz 72 10 were be VBD cord-004825-cdvnqfjz 72 11 incubated incubate VBN cord-004825-cdvnqfjz 72 12 in in IN cord-004825-cdvnqfjz 72 13 medium medium JJ cord-004825-cdvnqfjz 72 14 containing contain VBG cord-004825-cdvnqfjz 72 15 ammonium ammonium NN cord-004825-cdvnqfjz 72 16 chloride chloride NN cord-004825-cdvnqfjz 72 17 at at IN cord-004825-cdvnqfjz 72 18 pH pH NNP cord-004825-cdvnqfjz 72 19 7.5 7.5 CD cord-004825-cdvnqfjz 72 20 , , , cord-004825-cdvnqfjz 72 21 6.6 6.6 CD cord-004825-cdvnqfjz 72 22 and and CC cord-004825-cdvnqfjz 72 23 6.3 6.3 CD cord-004825-cdvnqfjz 72 24 during during IN cord-004825-cdvnqfjz 72 25 3 3 CD cord-004825-cdvnqfjz 72 26 h h NN cord-004825-cdvnqfjz 72 27 , , , cord-004825-cdvnqfjz 72 28 while while IN cord-004825-cdvnqfjz 72 29 there there EX cord-004825-cdvnqfjz 72 30 was be VBD cord-004825-cdvnqfjz 72 31 only only RB cord-004825-cdvnqfjz 72 32 31.5 31.5 CD cord-004825-cdvnqfjz 72 33 and and CC cord-004825-cdvnqfjz 72 34 22.3 22.3 CD cord-004825-cdvnqfjz 72 35 % % NN cord-004825-cdvnqfjz 72 36 inhibition inhibition NN cord-004825-cdvnqfjz 72 37 at at IN cord-004825-cdvnqfjz 72 38 pH pH NNP cord-004825-cdvnqfjz 72 39 6.t 6.t CD cord-004825-cdvnqfjz 72 40 and and CC cord-004825-cdvnqfjz 72 41 5.8 5.8 CD cord-004825-cdvnqfjz 72 42 , , , cord-004825-cdvnqfjz 72 43 respectively respectively RB cord-004825-cdvnqfjz 73 1 ( ( -LRB- cord-004825-cdvnqfjz 73 2 Fig Fig NNP cord-004825-cdvnqfjz 73 3 . . NNP cord-004825-cdvnqfjz 73 4 5 5 CD cord-004825-cdvnqfjz 73 5 ) ) -RRB- cord-004825-cdvnqfjz 73 6 . . . cord-004825-cdvnqfjz 74 1 At at IN cord-004825-cdvnqfjz 74 2 more more RBR cord-004825-cdvnqfjz 74 3 acidic acidic JJ cord-004825-cdvnqfjz 74 4 pH pH NNP cord-004825-cdvnqfjz 74 5 values value NNS cord-004825-cdvnqfjz 74 6 the the DT cord-004825-cdvnqfjz 74 7 action action NN cord-004825-cdvnqfjz 74 8 of of IN cord-004825-cdvnqfjz 74 9 ammonium ammonium NN cord-004825-cdvnqfjz 74 10 chloride chloride NN cord-004825-cdvnqfjz 74 11 was be VBD cord-004825-cdvnqfjz 74 12 almost almost RB cord-004825-cdvnqfjz 74 13 totally totally RB cord-004825-cdvnqfjz 74 14 abolished abolish VBN cord-004825-cdvnqfjz 74 15 . . . cord-004825-cdvnqfjz 75 1 To to TO cord-004825-cdvnqfjz 75 2 assess assess VB cord-004825-cdvnqfjz 75 3 that that IN cord-004825-cdvnqfjz 75 4 the the DT cord-004825-cdvnqfjz 75 5 acid acid NN cord-004825-cdvnqfjz 75 6 pH ph NN cord-004825-cdvnqfjz 75 7 is be VBZ cord-004825-cdvnqfjz 75 8 modifying modify VBG cord-004825-cdvnqfjz 75 9 the the DT cord-004825-cdvnqfjz 75 10 mechanism mechanism NN cord-004825-cdvnqfjz 75 11 of of IN cord-004825-cdvnqfjz 75 12 viral viral JJ cord-004825-cdvnqfjz 75 13 entry entry NN cord-004825-cdvnqfjz 75 14 and and CC cord-004825-cdvnqfjz 75 15 is be VBZ cord-004825-cdvnqfjz 75 16 not not RB cord-004825-cdvnqfjz 75 17 just just RB cord-004825-cdvnqfjz 75 18 neutralizing neutralize VBG cord-004825-cdvnqfjz 75 19 the the DT cord-004825-cdvnqfjz 75 20 ammonium ammonium NN cord-004825-cdvnqfjz 75 21 chloride chloride NN cord-004825-cdvnqfjz 75 22 , , , cord-004825-cdvnqfjz 75 23 JV JV NNP cord-004825-cdvnqfjz 75 24 bound bind VBD cord-004825-cdvnqfjz 75 25 cells cell NNS cord-004825-cdvnqfjz 75 26 were be VBD cord-004825-cdvnqfjz 75 27 briefly briefly RB cord-004825-cdvnqfjz 75 28 treated treat VBN cord-004825-cdvnqfjz 75 29 with with IN cord-004825-cdvnqfjz 75 30 medium medium NN cord-004825-cdvnqfjz 75 31 buffered buffer VBN cord-004825-cdvnqfjz 75 32 at at IN cord-004825-cdvnqfjz 75 33 different different JJ cord-004825-cdvnqfjz 75 34 pH ph NN cord-004825-cdvnqfjz 75 35 for for IN cord-004825-cdvnqfjz 75 36 2 2 CD cord-004825-cdvnqfjz 75 37 min min NN cord-004825-cdvnqfjz 75 38 and and CC cord-004825-cdvnqfjz 75 39 then then RB cord-004825-cdvnqfjz 75 40 incubated incubate VBD cord-004825-cdvnqfjz 75 41 for for IN cord-004825-cdvnqfjz 75 42 3 3 CD cord-004825-cdvnqfjz 75 43 h h NN cord-004825-cdvnqfjz 75 44 in in IN cord-004825-cdvnqfjz 75 45 neutral neutral JJ cord-004825-cdvnqfjz 75 46 medium medium NN cord-004825-cdvnqfjz 75 47 containing contain VBG cord-004825-cdvnqfjz 75 48 or or CC cord-004825-cdvnqfjz 75 49 not not RB cord-004825-cdvnqfjz 75 50 ammonium ammonium NN cord-004825-cdvnqfjz 75 51 chloride chloride NN cord-004825-cdvnqfjz 75 52 . . . cord-004825-cdvnqfjz 76 1 This this DT cord-004825-cdvnqfjz 76 2 treatment treatment NN cord-004825-cdvnqfjz 76 3 prevents prevent VBZ cord-004825-cdvnqfjz 76 4 endocytosis endocytosis NN cord-004825-cdvnqfjz 76 5 by by IN cord-004825-cdvnqfjz 76 6 inhibiting inhibit VBG cord-004825-cdvnqfjz 76 7 release release NN cord-004825-cdvnqfjz 76 8 into into IN cord-004825-cdvnqfjz 76 9 the the DT cord-004825-cdvnqfjz 76 10 cytoplasm cytoplasm NN cord-004825-cdvnqfjz 76 11 of of IN cord-004825-cdvnqfjz 76 12 virus virus NN cord-004825-cdvnqfjz 76 13 entered enter VBN cord-004825-cdvnqfjz 76 14 in in IN cord-004825-cdvnqfjz 76 15 endocytic endocytic JJ cord-004825-cdvnqfjz 76 16 vacuoles vacuole NNS cord-004825-cdvnqfjz 76 17 and and CC cord-004825-cdvnqfjz 76 18 allows allow VBZ cord-004825-cdvnqfjz 76 19 virus virus NN cord-004825-cdvnqfjz 76 20 entry entry NN cord-004825-cdvnqfjz 76 21 only only RB cord-004825-cdvnqfjz 76 22 by by IN cord-004825-cdvnqfjz 76 23 fusion fusion NN cord-004825-cdvnqfjz 76 24 at at IN cord-004825-cdvnqfjz 76 25 the the DT cord-004825-cdvnqfjz 76 26 plasma plasma NN cord-004825-cdvnqfjz 76 27 membrane membrane NN cord-004825-cdvnqfjz 76 28 [ [ -LRB- cord-004825-cdvnqfjz 76 29 26 26 CD cord-004825-cdvnqfjz 76 30 ] ] -RRB- cord-004825-cdvnqfjz 76 31 . . . cord-004825-cdvnqfjz 77 1 Under under IN cord-004825-cdvnqfjz 77 2 these these DT cord-004825-cdvnqfjz 77 3 experimental experimental JJ cord-004825-cdvnqfjz 77 4 conditions condition NNS cord-004825-cdvnqfjz 77 5 , , , cord-004825-cdvnqfjz 77 6 ammonium ammonium NN cord-004825-cdvnqfjz 77 7 chloride chloride NN cord-004825-cdvnqfjz 77 8 inhibition inhibition NN cord-004825-cdvnqfjz 77 9 was be VBD cord-004825-cdvnqfjz 77 10 partially partially RB cord-004825-cdvnqfjz 77 11 reversed reverse VBN cord-004825-cdvnqfjz 77 12 at at IN cord-004825-cdvnqfjz 77 13 pH pH NNP cord-004825-cdvnqfjz 77 14 5.5 5.5 CD cord-004825-cdvnqfjz 78 1 ( ( -LRB- cord-004825-cdvnqfjz 78 2 Fig Fig NNP cord-004825-cdvnqfjz 78 3 . . NNP cord-004825-cdvnqfjz 78 4 5 5 CD cord-004825-cdvnqfjz 78 5 ) ) -RRB- cord-004825-cdvnqfjz 78 6 . . . cord-004825-cdvnqfjz 79 1 To to TO cord-004825-cdvnqfjz 79 2 reinforce reinforce VB cord-004825-cdvnqfjz 79 3 that that IN cord-004825-cdvnqfjz 79 4 the the DT cord-004825-cdvnqfjz 79 5 membrane membrane NN cord-004825-cdvnqfjz 79 6 fusion fusion NN cord-004825-cdvnqfjz 79 7 activity activity NN cord-004825-cdvnqfjz 79 8 of of IN cord-004825-cdvnqfjz 79 9 Junin Junin NNP cord-004825-cdvnqfjz 79 10 virus virus NN cord-004825-cdvnqfjz 79 11 is be VBZ cord-004825-cdvnqfjz 79 12 expressed express VBN cord-004825-cdvnqfjz 79 13 at at IN cord-004825-cdvnqfjz 79 14 low low JJ cord-004825-cdvnqfjz 79 15 pH ph NN cord-004825-cdvnqfjz 79 16 , , , cord-004825-cdvnqfjz 79 17 the the DT cord-004825-cdvnqfjz 79 18 formation formation NN cord-004825-cdvnqfjz 79 19 of of IN cord-004825-cdvnqfjz 79 20 JV JV NNP cord-004825-cdvnqfjz 79 21 - - HYPH cord-004825-cdvnqfjz 79 22 induced induce VBN cord-004825-cdvnqfjz 79 23 syncytia syncytia NN cord-004825-cdvnqfjz 79 24 in in IN cord-004825-cdvnqfjz 79 25 infected infected JJ cord-004825-cdvnqfjz 79 26 Vero Vero NNP cord-004825-cdvnqfjz 79 27 cells cell NNS cord-004825-cdvnqfjz 79 28 incubated incubate VBN cord-004825-cdvnqfjz 79 29 in in IN cord-004825-cdvnqfjz 79 30 medium medium NN cord-004825-cdvnqfjz 79 31 at at IN cord-004825-cdvnqfjz 79 32 pH pH NNP cord-004825-cdvnqfjz 79 33 5.5 5.5 CD cord-004825-cdvnqfjz 79 34 or or CC cord-004825-cdvnqfjz 79 35 7.5 7.5 CD cord-004825-cdvnqfjz 79 36 was be VBD cord-004825-cdvnqfjz 79 37 quantitated quantitate VBN cord-004825-cdvnqfjz 79 38 . . . cord-004825-cdvnqfjz 80 1 Cell cell NN cord-004825-cdvnqfjz 80 2 fusion fusion NN cord-004825-cdvnqfjz 80 3 was be VBD cord-004825-cdvnqfjz 80 4 observed observe VBN cord-004825-cdvnqfjz 80 5 at at IN cord-004825-cdvnqfjz 80 6 48 48 CD cord-004825-cdvnqfjz 80 7 h h NN cord-004825-cdvnqfjz 80 8 p.i p.i NNP cord-004825-cdvnqfjz 80 9 . . . cord-004825-cdvnqfjz 81 1 but but CC cord-004825-cdvnqfjz 81 2 only only RB cord-004825-cdvnqfjz 81 3 at at IN cord-004825-cdvnqfjz 81 4 pH pH NNP cord-004825-cdvnqfjz 81 5 5.5 5.5 CD cord-004825-cdvnqfjz 81 6 , , , cord-004825-cdvnqfjz 81 7 there there EX cord-004825-cdvnqfjz 81 8 being be VBG cord-004825-cdvnqfjz 81 9 more more JJR cord-004825-cdvnqfjz 81 10 than than IN cord-004825-cdvnqfjz 81 11 10 10 CD cord-004825-cdvnqfjz 81 12 nuclei nucleus NNS cord-004825-cdvnqfjz 81 13 in in IN cord-004825-cdvnqfjz 81 14 the the DT cord-004825-cdvnqfjz 81 15 syncytia syncytia NN cord-004825-cdvnqfjz 81 16 whereas whereas IN cord-004825-cdvnqfjz 81 17 no no DT cord-004825-cdvnqfjz 81 18 polykaryon polykaryon NN cord-004825-cdvnqfjz 81 19 formation formation NN cord-004825-cdvnqfjz 81 20 was be VBD cord-004825-cdvnqfjz 81 21 seen see VBN cord-004825-cdvnqfjz 81 22 at at IN cord-004825-cdvnqfjz 81 23 neutral neutral JJ cord-004825-cdvnqfjz 81 24 pH pH NNP cord-004825-cdvnqfjz 82 1 ( ( -LRB- cord-004825-cdvnqfjz 82 2 Fig Fig NNP cord-004825-cdvnqfjz 82 3 . . . cord-004825-cdvnqfjz 82 4 6 6 CD cord-004825-cdvnqfjz 82 5 ) ) -RRB- cord-004825-cdvnqfjz 82 6 . . . cord-004825-cdvnqfjz 83 1 These these DT cord-004825-cdvnqfjz 83 2 studies study NNS cord-004825-cdvnqfjz 83 3 present present VBP cord-004825-cdvnqfjz 83 4 evidence evidence NN cord-004825-cdvnqfjz 83 5 that that IN cord-004825-cdvnqfjz 83 6 Junin Junin NNP cord-004825-cdvnqfjz 83 7 virus virus NN cord-004825-cdvnqfjz 83 8 entry entry NN cord-004825-cdvnqfjz 83 9 occurs occur VBZ cord-004825-cdvnqfjz 83 10 via via IN cord-004825-cdvnqfjz 83 11 a a DT cord-004825-cdvnqfjz 83 12 pH pH NNP cord-004825-cdvnqfjz 83 13 dependent dependent JJ cord-004825-cdvnqfjz 83 14 endocytic endocytic JJ cord-004825-cdvnqfjz 83 15 mechanism mechanism NN cord-004825-cdvnqfjz 83 16 mediated mediate VBN cord-004825-cdvnqfjz 83 17 by by IN cord-004825-cdvnqfjz 83 18 a a DT cord-004825-cdvnqfjz 83 19 glycoprotein glycoprotein NN cord-004825-cdvnqfjz 83 20 fusogenic fusogenic JJ cord-004825-cdvnqfjz 83 21 activity activity NN cord-004825-cdvnqfjz 83 22 . . . cord-004825-cdvnqfjz 84 1 Acidotropic Acidotropic NNP cord-004825-cdvnqfjz 84 2 bases basis NNS cord-004825-cdvnqfjz 84 3 are be VBP cord-004825-cdvnqfjz 84 4 known know VBN cord-004825-cdvnqfjz 84 5 to to TO cord-004825-cdvnqfjz 84 6 disrupt disrupt VB cord-004825-cdvnqfjz 84 7 endosomal endosomal NNP cord-004825-cdvnqfjz 84 8 functions function NNS cord-004825-cdvnqfjz 84 9 when when WRB cord-004825-cdvnqfjz 84 10 their -PRON- PRP$ cord-004825-cdvnqfjz 84 11 uncharged uncharged JJ cord-004825-cdvnqfjz 84 12 forms form NNS cord-004825-cdvnqfjz 84 13 enter enter VBP cord-004825-cdvnqfjz 84 14 endosomes endosome NNS cord-004825-cdvnqfjz 84 15 and and CC cord-004825-cdvnqfjz 84 16 lysosomes lysosome NNS cord-004825-cdvnqfjz 84 17 , , , cord-004825-cdvnqfjz 84 18 become become VBP cord-004825-cdvnqfjz 84 19 protonated protonated JJ cord-004825-cdvnqfjz 84 20 , , , cord-004825-cdvnqfjz 84 21 raise raise VB cord-004825-cdvnqfjz 84 22 the the DT cord-004825-cdvnqfjz 84 23 pH ph NN cord-004825-cdvnqfjz 84 24 and and CC cord-004825-cdvnqfjz 84 25 inhibit inhibit VB cord-004825-cdvnqfjz 84 26 the the DT cord-004825-cdvnqfjz 84 27 hydrolytic hydrolytic JJ cord-004825-cdvnqfjz 84 28 enzymes enzyme NNS cord-004825-cdvnqfjz 84 29 [ [ -LRB- cord-004825-cdvnqfjz 84 30 18 18 CD cord-004825-cdvnqfjz 84 31 ] ] -RRB- cord-004825-cdvnqfjz 84 32 . . . cord-004825-cdvnqfjz 85 1 We -PRON- PRP cord-004825-cdvnqfjz 85 2 have have VBP cord-004825-cdvnqfjz 85 3 demonstrated demonstrate VBN cord-004825-cdvnqfjz 85 4 here here RB cord-004825-cdvnqfjz 85 5 ( ( -LRB- cord-004825-cdvnqfjz 85 6 Figs fig NNS cord-004825-cdvnqfjz 85 7 . . . cord-004825-cdvnqfjz 86 1 1 1 CD cord-004825-cdvnqfjz 86 2 , , , cord-004825-cdvnqfjz 86 3 4 4 CD cord-004825-cdvnqfjz 86 4 ) ) -RRB- cord-004825-cdvnqfjz 86 5 . . . cord-004825-cdvnqfjz 87 1 The the DT cord-004825-cdvnqfjz 87 2 main main JJ cord-004825-cdvnqfjz 87 3 action action NN cord-004825-cdvnqfjz 87 4 of of IN cord-004825-cdvnqfjz 87 5 a a DT cord-004825-cdvnqfjz 87 6 m m NN cord-004825-cdvnqfjz 87 7 m m NN cord-004825-cdvnqfjz 87 8 o o NN cord-004825-cdvnqfjz 87 9 n n NN cord-004825-cdvnqfjz 87 10 i i NN cord-004825-cdvnqfjz 87 11 u u NN cord-004825-cdvnqfjz 87 12 m m NN cord-004825-cdvnqfjz 87 13 chloride chloride NN cord-004825-cdvnqfjz 87 14 on on IN cord-004825-cdvnqfjz 87 15 JV JV NNP cord-004825-cdvnqfjz 87 16 replication replication NN cord-004825-cdvnqfjz 87 17 was be VBD cord-004825-cdvnqfjz 87 18 exerted exert VBN cord-004825-cdvnqfjz 87 19 at at IN cord-004825-cdvnqfjz 87 20 an an DT cord-004825-cdvnqfjz 87 21 early early JJ cord-004825-cdvnqfjz 87 22 step step NN cord-004825-cdvnqfjz 87 23 in in IN cord-004825-cdvnqfjz 87 24 the the DT cord-004825-cdvnqfjz 87 25 multiplication multiplication NN cord-004825-cdvnqfjz 87 26 cycle cycle NN cord-004825-cdvnqfjz 87 27 ( ( -LRB- cord-004825-cdvnqfjz 87 28 Fig fig NN cord-004825-cdvnqfjz 87 29 . . NNP cord-004825-cdvnqfjz 87 30 2 2 CD cord-004825-cdvnqfjz 87 31 ) ) -RRB- cord-004825-cdvnqfjz 87 32 . . . cord-004825-cdvnqfjz 88 1 However however RB cord-004825-cdvnqfjz 88 2 , , , cord-004825-cdvnqfjz 88 3 virus virus NN cord-004825-cdvnqfjz 88 4 attachment attachment NN cord-004825-cdvnqfjz 88 5 which which WDT cord-004825-cdvnqfjz 88 6 occurred occur VBD cord-004825-cdvnqfjz 88 7 at at IN cord-004825-cdvnqfjz 88 8 4 4 CD cord-004825-cdvnqfjz 88 9 ° ° NN cord-004825-cdvnqfjz 88 10 C C NNP cord-004825-cdvnqfjz 88 11 was be VBD cord-004825-cdvnqfjz 88 12 not not RB cord-004825-cdvnqfjz 88 13 inhibited inhibit VBN cord-004825-cdvnqfjz 88 14 as as IN cord-004825-cdvnqfjz 88 15 it -PRON- PRP cord-004825-cdvnqfjz 88 16 is be VBZ cord-004825-cdvnqfjz 88 17 shown show VBN cord-004825-cdvnqfjz 88 18 in in IN cord-004825-cdvnqfjz 88 19 Table Table NNP cord-004825-cdvnqfjz 88 20 1 1 CD cord-004825-cdvnqfjz 88 21 . . . cord-004825-cdvnqfjz 89 1 Virions virion NNS cord-004825-cdvnqfjz 90 1 b b LS cord-004825-cdvnqfjz 90 2 o o UH cord-004825-cdvnqfjz 90 3 u u NN cord-004825-cdvnqfjz 90 4 n n NN cord-004825-cdvnqfjz 90 5 d d NN cord-004825-cdvnqfjz 90 6 to to IN cord-004825-cdvnqfjz 90 7 cells cell NNS cord-004825-cdvnqfjz 90 8 at at IN cord-004825-cdvnqfjz 90 9 4 4 CD cord-004825-cdvnqfjz 90 10 ° ° NN cord-004825-cdvnqfjz 91 1 C C NNP cord-004825-cdvnqfjz 91 2 are be VBP cord-004825-cdvnqfjz 91 3 compelled compel VBN cord-004825-cdvnqfjz 91 4 to to TO cord-004825-cdvnqfjz 91 5 internalize internalize VB cord-004825-cdvnqfjz 91 6 when when WRB cord-004825-cdvnqfjz 91 7 the the DT cord-004825-cdvnqfjz 91 8 temperature temperature NN cord-004825-cdvnqfjz 91 9 of of IN cord-004825-cdvnqfjz 91 10 incubation incubation NN cord-004825-cdvnqfjz 91 11 is be VBZ cord-004825-cdvnqfjz 91 12 raised raise VBN cord-004825-cdvnqfjz 91 13 to to IN cord-004825-cdvnqfjz 91 14 37 37 CD cord-004825-cdvnqfjz 91 15 ° ° NN cord-004825-cdvnqfjz 91 16 C c NN cord-004825-cdvnqfjz 91 17 . . . cord-004825-cdvnqfjz 92 1 When when WRB cord-004825-cdvnqfjz 92 2 JV JV NNP cord-004825-cdvnqfjz 92 3 internalization internalization NN cord-004825-cdvnqfjz 92 4 , , , cord-004825-cdvnqfjz 92 5 the the DT cord-004825-cdvnqfjz 92 6 next next JJ cord-004825-cdvnqfjz 92 7 stage stage NN cord-004825-cdvnqfjz 92 8 of of IN cord-004825-cdvnqfjz 92 9 the the DT cord-004825-cdvnqfjz 92 10 viral viral JJ cord-004825-cdvnqfjz 92 11 cycle cycle NN cord-004825-cdvnqfjz 92 12 , , , cord-004825-cdvnqfjz 92 13 was be VBD cord-004825-cdvnqfjz 92 14 studied study VBN cord-004825-cdvnqfjz 92 15 a a DT cord-004825-cdvnqfjz 92 16 significant significant JJ cord-004825-cdvnqfjz 92 17 inhibition inhibition NN cord-004825-cdvnqfjz 92 18 was be VBD cord-004825-cdvnqfjz 92 19 observed observe VBN cord-004825-cdvnqfjz 92 20 during during IN cord-004825-cdvnqfjz 92 21 the the DT cord-004825-cdvnqfjz 92 22 first first JJ cord-004825-cdvnqfjz 92 23 372 372 CD cord-004825-cdvnqfjz 92 24 V. V. NNP cord-004825-cdvnqfjz 92 25 Castilla Castilla NNP cord-004825-cdvnqfjz 92 26 et et NNP cord-004825-cdvnqfjz 92 27 al al NNP cord-004825-cdvnqfjz 92 28 . . . cord-004825-cdvnqfjz 93 1 hour hour NN cord-004825-cdvnqfjz 93 2 after after IN cord-004825-cdvnqfjz 93 3 adsorption adsorption NN cord-004825-cdvnqfjz 93 4 . . . cord-004825-cdvnqfjz 94 1 In in IN cord-004825-cdvnqfjz 94 2 the the DT cord-004825-cdvnqfjz 94 3 presence presence NN cord-004825-cdvnqfjz 94 4 of of IN cord-004825-cdvnqfjz 94 5 ammonium ammonium NN cord-004825-cdvnqfjz 94 6 chloride chloride NN cord-004825-cdvnqfjz 94 7 an an DT cord-004825-cdvnqfjz 94 8 increasing increase VBG cord-004825-cdvnqfjz 94 9 reduction reduction NN cord-004825-cdvnqfjz 94 10 in in IN cord-004825-cdvnqfjz 94 11 the the DT cord-004825-cdvnqfjz 94 12 number number NN cord-004825-cdvnqfjz 94 13 of of IN cord-004825-cdvnqfjz 94 14 proteinase proteinase NN cord-004825-cdvnqfjz 94 15 K k NN cord-004825-cdvnqfjz 94 16 - - HYPH cord-004825-cdvnqfjz 94 17 resistant resistant JJ cord-004825-cdvnqfjz 94 18 infectious infectious JJ cord-004825-cdvnqfjz 94 19 centers center NNS cord-004825-cdvnqfjz 94 20 was be VBD cord-004825-cdvnqfjz 94 21 detected detect VBN cord-004825-cdvnqfjz 94 22 ( ( -LRB- cord-004825-cdvnqfjz 94 23 Fig Fig NNP cord-004825-cdvnqfjz 94 24 . . . cord-004825-cdvnqfjz 94 25 3 3 CD cord-004825-cdvnqfjz 94 26 . . . cord-004825-cdvnqfjz 94 27 ) ) -RRB- cord-004825-cdvnqfjz 95 1 It -PRON- PRP cord-004825-cdvnqfjz 95 2 might may MD cord-004825-cdvnqfjz 95 3 be be VB cord-004825-cdvnqfjz 95 4 due due JJ cord-004825-cdvnqfjz 95 5 to to IN cord-004825-cdvnqfjz 95 6 the the DT cord-004825-cdvnqfjz 95 7 lysosomal lysosomal JJ cord-004825-cdvnqfjz 95 8 degradation degradation NN cord-004825-cdvnqfjz 95 9 of of IN cord-004825-cdvnqfjz 95 10 endocytosed endocytose VBN cord-004825-cdvnqfjz 95 11 virions virion NNS cord-004825-cdvnqfjz 95 12 unable unable JJ cord-004825-cdvnqfjz 95 13 to to TO cord-004825-cdvnqfjz 95 14 fuse fuse VB cord-004825-cdvnqfjz 95 15 with with IN cord-004825-cdvnqfjz 95 16 endosomal endosomal NNP cord-004825-cdvnqfjz 95 17 membranes membrane NNS cord-004825-cdvnqfjz 95 18 , , , cord-004825-cdvnqfjz 95 19 as as IN cord-004825-cdvnqfjz 95 20 seen see VBN cord-004825-cdvnqfjz 95 21 for for IN cord-004825-cdvnqfjz 95 22 other other JJ cord-004825-cdvnqfjz 95 23 enveloped envelop VBN cord-004825-cdvnqfjz 95 24 viruses virus NNS cord-004825-cdvnqfjz 95 25 . . . cord-004825-cdvnqfjz 96 1 These these DT cord-004825-cdvnqfjz 96 2 data datum NNS cord-004825-cdvnqfjz 96 3 were be VBD cord-004825-cdvnqfjz 96 4 indicative indicative JJ cord-004825-cdvnqfjz 96 5 of of IN cord-004825-cdvnqfjz 96 6 a a DT cord-004825-cdvnqfjz 96 7 process process NN cord-004825-cdvnqfjz 96 8 of of IN cord-004825-cdvnqfjz 96 9 low low JJ cord-004825-cdvnqfjz 96 10 pH ph NN cord-004825-cdvnqfjz 96 11 - - HYPH cord-004825-cdvnqfjz 96 12 dependent dependent JJ cord-004825-cdvnqfjz 96 13 endosomal endosomal NNP cord-004825-cdvnqfjz 96 14 fusion fusion NN cord-004825-cdvnqfjz 96 15 for for IN cord-004825-cdvnqfjz 96 16 JV JV NNP cord-004825-cdvnqfjz 96 17 uptake uptake NN cord-004825-cdvnqfjz 96 18 . . . cord-004825-cdvnqfjz 97 1 In in IN cord-004825-cdvnqfjz 97 2 fact fact NN cord-004825-cdvnqfjz 97 3 , , , cord-004825-cdvnqfjz 97 4 a a DT cord-004825-cdvnqfjz 97 5 bypass bypass NN cord-004825-cdvnqfjz 97 6 of of IN cord-004825-cdvnqfjz 97 7 the the DT cord-004825-cdvnqfjz 97 8 ammonium ammonium NN cord-004825-cdvnqfjz 97 9 chloride chloride NN cord-004825-cdvnqfjz 97 10 block block NN cord-004825-cdvnqfjz 97 11 of of IN cord-004825-cdvnqfjz 97 12 JV JV NNP cord-004825-cdvnqfjz 97 13 infection infection NN cord-004825-cdvnqfjz 97 14 was be VBD cord-004825-cdvnqfjz 97 15 achieved achieve VBN cord-004825-cdvnqfjz 97 16 when when WRB cord-004825-cdvnqfjz 97 17 the the DT cord-004825-cdvnqfjz 97 18 extracellular extracellular JJ cord-004825-cdvnqfjz 97 19 medium medium NN cord-004825-cdvnqfjz 97 20 was be VBD cord-004825-cdvnqfjz 97 21 at at IN cord-004825-cdvnqfjz 97 22 a a DT cord-004825-cdvnqfjz 97 23 pH ph NN cord-004825-cdvnqfjz 97 24 below below IN cord-004825-cdvnqfjz 97 25 6.1 6.1 CD cord-004825-cdvnqfjz 98 1 ( ( -LRB- cord-004825-cdvnqfjz 98 2 Fig Fig NNP cord-004825-cdvnqfjz 98 3 . . NNP cord-004825-cdvnqfjz 98 4 5 5 CD cord-004825-cdvnqfjz 98 5 ) ) -RRB- cord-004825-cdvnqfjz 98 6 , , , cord-004825-cdvnqfjz 98 7 suggesting suggest VBG cord-004825-cdvnqfjz 98 8 that that IN cord-004825-cdvnqfjz 98 9 the the DT cord-004825-cdvnqfjz 98 10 acidic acidic JJ cord-004825-cdvnqfjz 98 11 conditions condition NNS cord-004825-cdvnqfjz 98 12 would would MD cord-004825-cdvnqfjz 98 13 probably probably RB cord-004825-cdvnqfjz 98 14 trigger trigger VB cord-004825-cdvnqfjz 98 15 direct direct JJ cord-004825-cdvnqfjz 98 16 fusion fusion NN cord-004825-cdvnqfjz 98 17 of of IN cord-004825-cdvnqfjz 98 18 virus virus NN cord-004825-cdvnqfjz 98 19 envelope envelope NN cord-004825-cdvnqfjz 98 20 with with IN cord-004825-cdvnqfjz 98 21 the the DT cord-004825-cdvnqfjz 98 22 cell cell NN cord-004825-cdvnqfjz 98 23 membrane membrane NN cord-004825-cdvnqfjz 98 24 . . . cord-004825-cdvnqfjz 99 1 The the DT cord-004825-cdvnqfjz 99 2 location location NN cord-004825-cdvnqfjz 99 3 of of IN cord-004825-cdvnqfjz 99 4 penetration penetration NN cord-004825-cdvnqfjz 99 5 is be VBZ cord-004825-cdvnqfjz 99 6 determined determine VBN cord-004825-cdvnqfjz 99 7 by by IN cord-004825-cdvnqfjz 99 8 the the DT cord-004825-cdvnqfjz 99 9 pH pH NNP cord-004825-cdvnqfjz 99 10 threshold threshold NN cord-004825-cdvnqfjz 99 11 of of IN cord-004825-cdvnqfjz 99 12 fusion fusion NN cord-004825-cdvnqfjz 99 13 activity activity NN cord-004825-cdvnqfjz 99 14 [ [ -LRB- cord-004825-cdvnqfjz 99 15 15 15 CD cord-004825-cdvnqfjz 99 16 ] ] -RRB- cord-004825-cdvnqfjz 99 17 . . . cord-004825-cdvnqfjz 100 1 For for IN cord-004825-cdvnqfjz 100 2 some some DT cord-004825-cdvnqfjz 100 3 viruses virus NNS cord-004825-cdvnqfjz 100 4 such such JJ cord-004825-cdvnqfjz 100 5 as as IN cord-004825-cdvnqfjz 100 6 Semliki Semliki NNP cord-004825-cdvnqfjz 100 7 Forest Forest NNP cord-004825-cdvnqfjz 100 8 virus virus NN cord-004825-cdvnqfjz 100 9 , , , cord-004825-cdvnqfjz 100 10 fusion fusion NN cord-004825-cdvnqfjz 100 11 occurs occur VBZ cord-004825-cdvnqfjz 100 12 at at IN cord-004825-cdvnqfjz 100 13 a a DT cord-004825-cdvnqfjz 100 14 pH pH NNP cord-004825-cdvnqfjz 100 15 6.2 6.2 CD cord-004825-cdvnqfjz 100 16 in in IN cord-004825-cdvnqfjz 100 17 early early JJ cord-004825-cdvnqfjz 100 18 endosomes endosome NNS cord-004825-cdvnqfjz 100 19 , , , cord-004825-cdvnqfjz 100 20 whereas whereas IN cord-004825-cdvnqfjz 100 21 Influenza Influenza NNP cord-004825-cdvnqfjz 100 22 virus virus NN cord-004825-cdvnqfjz 100 23 X-31 X-31 NNP cord-004825-cdvnqfjz 100 24 requires require VBZ cord-004825-cdvnqfjz 100 25 pH pH NNP cord-004825-cdvnqfjz 100 26 5.3 5.3 CD cord-004825-cdvnqfjz 100 27 and and CC cord-004825-cdvnqfjz 100 28 fuses fuse NNS cord-004825-cdvnqfjz 100 29 in in IN cord-004825-cdvnqfjz 100 30 the the DT cord-004825-cdvnqfjz 100 31 late late JJ cord-004825-cdvnqfjz 100 32 endosomes endosome NNS cord-004825-cdvnqfjz 100 33 [ [ -LRB- cord-004825-cdvnqfjz 100 34 12 12 CD cord-004825-cdvnqfjz 100 35 , , , cord-004825-cdvnqfjz 100 36 24 24 CD cord-004825-cdvnqfjz 100 37 , , , cord-004825-cdvnqfjz 100 38 25 25 CD cord-004825-cdvnqfjz 100 39 ] ] -RRB- cord-004825-cdvnqfjz 100 40 . . . cord-004825-cdvnqfjz 101 1 For for IN cord-004825-cdvnqfjz 101 2 JV JV NNP cord-004825-cdvnqfjz 101 3 entry entry NN cord-004825-cdvnqfjz 101 4 , , , cord-004825-cdvnqfjz 101 5 fusion fusion NN cord-004825-cdvnqfjz 101 6 seems seem VBZ cord-004825-cdvnqfjz 101 7 to to TO cord-004825-cdvnqfjz 101 8 occur occur VB cord-004825-cdvnqfjz 101 9 in in IN cord-004825-cdvnqfjz 101 10 endosomes endosome NNS cord-004825-cdvnqfjz 101 11 where where WRB cord-004825-cdvnqfjz 101 12 the the DT cord-004825-cdvnqfjz 101 13 pH pH NNP cord-004825-cdvnqfjz 101 14 is be VBZ cord-004825-cdvnqfjz 101 15 6.1 6.1 CD cord-004825-cdvnqfjz 101 16 or or CC cord-004825-cdvnqfjz 101 17 lower low JJR cord-004825-cdvnqfjz 101 18 . . . cord-004825-cdvnqfjz 102 1 The the DT cord-004825-cdvnqfjz 102 2 acid acid JJ cord-004825-cdvnqfjz 102 3 environment environment NN cord-004825-cdvnqfjz 102 4 may may MD cord-004825-cdvnqfjz 102 5 be be VB cord-004825-cdvnqfjz 102 6 responsible responsible JJ cord-004825-cdvnqfjz 102 7 for for IN cord-004825-cdvnqfjz 102 8 structural structural JJ cord-004825-cdvnqfjz 102 9 changes change NNS cord-004825-cdvnqfjz 102 10 in in IN cord-004825-cdvnqfjz 102 11 JV JV NNP cord-004825-cdvnqfjz 102 12 external external JJ cord-004825-cdvnqfjz 102 13 proteins protein NNS cord-004825-cdvnqfjz 102 14 allowing allow VBG cord-004825-cdvnqfjz 102 15 membrane membrane NN cord-004825-cdvnqfjz 102 16 fusion fusion NN cord-004825-cdvnqfjz 102 17 and and CC cord-004825-cdvnqfjz 102 18 facilitating facilitate VBG cord-004825-cdvnqfjz 102 19 viral viral JJ cord-004825-cdvnqfjz 102 20 uncoating uncoating NN cord-004825-cdvnqfjz 102 21 as as IN cord-004825-cdvnqfjz 102 22 described describe VBN cord-004825-cdvnqfjz 102 23 for for IN cord-004825-cdvnqfjz 102 24 Influenza Influenza NNP cord-004825-cdvnqfjz 102 25 virus virus NN cord-004825-cdvnqfjz 102 26 [ [ -LRB- cord-004825-cdvnqfjz 102 27 7 7 CD cord-004825-cdvnqfjz 102 28 ] ] -RRB- cord-004825-cdvnqfjz 102 29 , , , cord-004825-cdvnqfjz 102 30 Rubella rubella NN cord-004825-cdvnqfjz 102 31 virus virus NN cord-004825-cdvnqfjz 102 32 [ [ -LRB- cord-004825-cdvnqfjz 102 33 17 17 CD cord-004825-cdvnqfjz 102 34 ] ] -RRB- cord-004825-cdvnqfjz 102 35 , , , cord-004825-cdvnqfjz 102 36 West West NNP cord-004825-cdvnqfjz 102 37 Nile Nile NNP cord-004825-cdvnqfjz 102 38 virus virus NN cord-004825-cdvnqfjz 102 39 [ [ -LRB- cord-004825-cdvnqfjz 102 40 13 13 CD cord-004825-cdvnqfjz 102 41 ] ] -RRB- cord-004825-cdvnqfjz 102 42 and and CC cord-004825-cdvnqfjz 102 43 tick tick VB cord-004825-cdvnqfjz 102 44 - - HYPH cord-004825-cdvnqfjz 102 45 borne bear VBN cord-004825-cdvnqfjz 102 46 encephalitis encephalitis JJ cord-004825-cdvnqfjz 102 47 virus virus NN cord-004825-cdvnqfjz 102 48 [ [ -LRB- cord-004825-cdvnqfjz 102 49 11 11 CD cord-004825-cdvnqfjz 102 50 ] ] -RRB- cord-004825-cdvnqfjz 102 51 . . . cord-004825-cdvnqfjz 103 1 It -PRON- PRP cord-004825-cdvnqfjz 103 2 is be VBZ cord-004825-cdvnqfjz 103 3 possible possible JJ cord-004825-cdvnqfjz 103 4 to to TO cord-004825-cdvnqfjz 103 5 induce induce VB cord-004825-cdvnqfjz 103 6 fusion fusion NN cord-004825-cdvnqfjz 103 7 in in IN cord-004825-cdvnqfjz 103 8 some some DT cord-004825-cdvnqfjz 103 9 model model NN cord-004825-cdvnqfjz 103 10 systems system NNS cord-004825-cdvnqfjz 103 11 by by IN cord-004825-cdvnqfjz 103 12 mimicking mimic VBG cord-004825-cdvnqfjz 103 13 the the DT cord-004825-cdvnqfjz 103 14 low low JJ cord-004825-cdvnqfjz 103 15 pH pH NNP cord-004825-cdvnqfjz 103 16 intracellular intracellular JJ cord-004825-cdvnqfjz 103 17 conditions condition NNS cord-004825-cdvnqfjz 103 18 . . . cord-004825-cdvnqfjz 104 1 In in IN cord-004825-cdvnqfjz 104 2 particular particular JJ cord-004825-cdvnqfjz 104 3 , , , cord-004825-cdvnqfjz 104 4 Mann Mann NNP cord-004825-cdvnqfjz 104 5 et et NNP cord-004825-cdvnqfjz 104 6 al al NNP cord-004825-cdvnqfjz 104 7 . . . cord-004825-cdvnqfjz 105 1 [ [ -LRB- cord-004825-cdvnqfjz 105 2 16 16 CD cord-004825-cdvnqfjz 105 3 - - SYM cord-004825-cdvnqfjz 105 4 1 1 CD cord-004825-cdvnqfjz 105 5 have have VBP cord-004825-cdvnqfjz 105 6 shown show VBN cord-004825-cdvnqfjz 105 7 that that IN cord-004825-cdvnqfjz 105 8 Sindbis Sindbis NNP cord-004825-cdvnqfjz 105 9 virus virus NN cord-004825-cdvnqfjz 105 10 infected infect VBN cord-004825-cdvnqfjz 105 11 cells cell NNS cord-004825-cdvnqfjz 105 12 express express VBP cord-004825-cdvnqfjz 105 13 a a DT cord-004825-cdvnqfjz 105 14 fusion fusion NN cord-004825-cdvnqfjz 105 15 function function NN cord-004825-cdvnqfjz 105 16 after after IN cord-004825-cdvnqfjz 105 17 treatment treatment NN cord-004825-cdvnqfjz 105 18 at at IN cord-004825-cdvnqfjz 105 19 acid acid NNP cord-004825-cdvnqfjz 105 20 pH. pH. NNP cord-004825-cdvnqfjz 106 1 We -PRON- PRP cord-004825-cdvnqfjz 106 2 demonstrated demonstrate VBD cord-004825-cdvnqfjz 106 3 that that IN cord-004825-cdvnqfjz 106 4 Junin Junin NNP cord-004825-cdvnqfjz 106 5 virus virus NN cord-004825-cdvnqfjz 106 6 can can MD cord-004825-cdvnqfjz 106 7 mediate mediate VB cord-004825-cdvnqfjz 106 8 cell cell NN cord-004825-cdvnqfjz 106 9 fusion fusion NN cord-004825-cdvnqfjz 106 10 at at IN cord-004825-cdvnqfjz 106 11 pH pH NNP cord-004825-cdvnqfjz 106 12 5.5 5.5 CD cord-004825-cdvnqfjz 106 13 producing produce VBG cord-004825-cdvnqfjz 106 14 polykaryocytes polykaryocyte NNS cord-004825-cdvnqfjz 106 15 in in IN cord-004825-cdvnqfjz 106 16 which which WDT cord-004825-cdvnqfjz 106 17 over over IN cord-004825-cdvnqfjz 106 18 40 40 CD cord-004825-cdvnqfjz 106 19 % % NN cord-004825-cdvnqfjz 106 20 of of IN cord-004825-cdvnqfjz 106 21 the the DT cord-004825-cdvnqfjz 106 22 cells cell NNS cord-004825-cdvnqfjz 106 23 in in IN cord-004825-cdvnqfjz 106 24 the the DT cord-004825-cdvnqfjz 106 25 monolayer monolayer NN cord-004825-cdvnqfjz 106 26 participate participate VB cord-004825-cdvnqfjz 106 27 ( ( -LRB- cord-004825-cdvnqfjz 106 28 Fig fig NN cord-004825-cdvnqfjz 106 29 . . . cord-004825-cdvnqfjz 106 30 6 6 CD cord-004825-cdvnqfjz 106 31 ) ) -RRB- cord-004825-cdvnqfjz 106 32 . . . cord-004825-cdvnqfjz 107 1 Thus thus RB cord-004825-cdvnqfjz 107 2 , , , cord-004825-cdvnqfjz 107 3 this this DT cord-004825-cdvnqfjz 107 4 result result NN cord-004825-cdvnqfjz 107 5 offers offer VBZ cord-004825-cdvnqfjz 107 6 indirect indirect JJ cord-004825-cdvnqfjz 107 7 support support NN cord-004825-cdvnqfjz 107 8 for for IN cord-004825-cdvnqfjz 107 9 the the DT cord-004825-cdvnqfjz 107 10 conclusion conclusion NN cord-004825-cdvnqfjz 107 11 that that IN cord-004825-cdvnqfjz 107 12 the the DT cord-004825-cdvnqfjz 107 13 route route NN cord-004825-cdvnqfjz 107 14 of of IN cord-004825-cdvnqfjz 107 15 JV JV NNP cord-004825-cdvnqfjz 107 16 entry entry NN cord-004825-cdvnqfjz 107 17 is be VBZ cord-004825-cdvnqfjz 107 18 pH ph NN cord-004825-cdvnqfjz 107 19 - - HYPH cord-004825-cdvnqfjz 107 20 dependent dependent JJ cord-004825-cdvnqfjz 107 21 in in IN cord-004825-cdvnqfjz 107 22 Vero Vero NNP cord-004825-cdvnqfjz 107 23 cells cell NNS cord-004825-cdvnqfjz 107 24 . . . cord-004825-cdvnqfjz 108 1 Major major JJ cord-004825-cdvnqfjz 108 2 expression expression NN cord-004825-cdvnqfjz 108 3 of of IN cord-004825-cdvnqfjz 108 4 GP38 GP38 NNP cord-004825-cdvnqfjz 108 5 , , , cord-004825-cdvnqfjz 108 6 the the DT cord-004825-cdvnqfjz 108 7 main main JJ cord-004825-cdvnqfjz 108 8 external external JJ cord-004825-cdvnqfjz 108 9 envelope envelope NN cord-004825-cdvnqfjz 108 10 glycoprotein glycoprotein NN cord-004825-cdvnqfjz 108 11 [ [ -LRB- cord-004825-cdvnqfjz 108 12 19 19 CD cord-004825-cdvnqfjz 108 13 ] ] -RRB- cord-004825-cdvnqfjz 108 14 , , , cord-004825-cdvnqfjz 108 15 was be VBD cord-004825-cdvnqfjz 108 16 observed observe VBN cord-004825-cdvnqfjz 108 17 in in IN cord-004825-cdvnqfjz 108 18 the the DT cord-004825-cdvnqfjz 108 19 surface surface NN cord-004825-cdvnqfjz 108 20 of of IN cord-004825-cdvnqfjz 108 21 JV JV NNP cord-004825-cdvnqfjz 108 22 infected infect VBN cord-004825-cdvnqfjz 108 23 cells cell NNS cord-004825-cdvnqfjz 108 24 at at IN cord-004825-cdvnqfjz 108 25 48 48 CD cord-004825-cdvnqfjz 108 26 h h NN cord-004825-cdvnqfjz 108 27 p.i p.i NNP cord-004825-cdvnqfjz 108 28 . . NNP cord-004825-cdvnqfjz 108 29 , , , cord-004825-cdvnqfjz 108 30 by by IN cord-004825-cdvnqfjz 108 31 immunofluorescence immunofluorescence NN cord-004825-cdvnqfjz 108 32 assay assay NN cord-004825-cdvnqfjz 108 33 ( ( -LRB- cord-004825-cdvnqfjz 108 34 data datum NNS cord-004825-cdvnqfjz 108 35 not not RB cord-004825-cdvnqfjz 108 36 shown show VBN cord-004825-cdvnqfjz 108 37 ) ) -RRB- cord-004825-cdvnqfjz 108 38 . . . cord-004825-cdvnqfjz 109 1 Thus thus RB cord-004825-cdvnqfjz 109 2 , , , cord-004825-cdvnqfjz 109 3 GP38 GP38 NNP cord-004825-cdvnqfjz 109 4 might may MD cord-004825-cdvnqfjz 109 5 be be VB cord-004825-cdvnqfjz 109 6 responsible responsible JJ cord-004825-cdvnqfjz 109 7 for for IN cord-004825-cdvnqfjz 109 8 JV JV NNP cord-004825-cdvnqfjz 109 9 - - HYPH cord-004825-cdvnqfjz 109 10 induced induce VBN cord-004825-cdvnqfjz 109 11 membrane membrane NN cord-004825-cdvnqfjz 109 12 fusion fusion NN cord-004825-cdvnqfjz 109 13 in in IN cord-004825-cdvnqfjz 109 14 the the DT cord-004825-cdvnqfjz 109 15 endosome endosome NN cord-004825-cdvnqfjz 109 16 or or CC cord-004825-cdvnqfjz 109 17 in in IN cord-004825-cdvnqfjz 109 18 the the DT cord-004825-cdvnqfjz 109 19 cell cell NN cord-004825-cdvnqfjz 109 20 surface surface NN cord-004825-cdvnqfjz 109 21 . . . cord-004825-cdvnqfjz 110 1 This this DT cord-004825-cdvnqfjz 110 2 proposal proposal NN cord-004825-cdvnqfjz 110 3 is be VBZ cord-004825-cdvnqfjz 110 4 also also RB cord-004825-cdvnqfjz 110 5 supported support VBN cord-004825-cdvnqfjz 110 6 by by IN cord-004825-cdvnqfjz 110 7 results result NNS cord-004825-cdvnqfjz 110 8 obtained obtain VBN cord-004825-cdvnqfjz 110 9 with with IN cord-004825-cdvnqfjz 110 10 C167 c167 CD cord-004825-cdvnqfjz 110 11 , , , cord-004825-cdvnqfjz 110 12 a a DT cord-004825-cdvnqfjz 110 13 host host NN cord-004825-cdvnqfjz 110 14 - - HYPH cord-004825-cdvnqfjz 110 15 range range NN cord-004825-cdvnqfjz 110 16 mutant mutant NN cord-004825-cdvnqfjz 110 17 of of IN cord-004825-cdvnqfjz 110 18 JV JV NNP cord-004825-cdvnqfjz 110 19 , , , cord-004825-cdvnqfjz 110 20 with with IN cord-004825-cdvnqfjz 110 21 an an DT cord-004825-cdvnqfjz 110 22 alteration alteration NN cord-004825-cdvnqfjz 110 23 in in IN cord-004825-cdvnqfjz 110 24 GP38 GP38 NNP cord-004825-cdvnqfjz 110 25 detected detect VBN cord-004825-cdvnqfjz 110 26 by by IN cord-004825-cdvnqfjz 110 27 peptide peptide NN cord-004825-cdvnqfjz 110 28 mapping mapping NN cord-004825-cdvnqfjz 110 29 and and CC cord-004825-cdvnqfjz 110 30 a a DT cord-004825-cdvnqfjz 110 31 blockade blockade NN cord-004825-cdvnqfjz 110 32 in in IN cord-004825-cdvnqfjz 110 33 adsorption adsorption NN cord-004825-cdvnqfjz 110 34 - - HYPH cord-004825-cdvnqfjz 110 35 penetration penetration NN cord-004825-cdvnqfjz 110 36 pathway pathway NN cord-004825-cdvnqfjz 110 37 [ [ -LRB- cord-004825-cdvnqfjz 110 38 21 21 CD cord-004825-cdvnqfjz 110 39 , , , cord-004825-cdvnqfjz 110 40 22 22 CD cord-004825-cdvnqfjz 110 41 ] ] -RRB- cord-004825-cdvnqfjz 110 42 . . . cord-004825-cdvnqfjz 111 1 In in IN cord-004825-cdvnqfjz 111 2 conclusion conclusion NN cord-004825-cdvnqfjz 111 3 , , , cord-004825-cdvnqfjz 111 4 our -PRON- PRP$ cord-004825-cdvnqfjz 111 5 data datum NNS cord-004825-cdvnqfjz 111 6 demonstrate demonstrate VBP cord-004825-cdvnqfjz 111 7 for for IN cord-004825-cdvnqfjz 111 8 the the DT cord-004825-cdvnqfjz 111 9 first first JJ cord-004825-cdvnqfjz 111 10 time time NN cord-004825-cdvnqfjz 111 11 that that WDT cord-004825-cdvnqfjz 111 12 JV JV NNP cord-004825-cdvnqfjz 111 13 enters enter VBZ cord-004825-cdvnqfjz 111 14 the the DT cord-004825-cdvnqfjz 111 15 cell cell NN cord-004825-cdvnqfjz 111 16 by by IN cord-004825-cdvnqfjz 111 17 a a DT cord-004825-cdvnqfjz 111 18 receptor receptor NN cord-004825-cdvnqfjz 111 19 mediated mediate VBN cord-004825-cdvnqfjz 111 20 endocytic endocytic JJ cord-004825-cdvnqfjz 111 21 pathway pathway NN cord-004825-cdvnqfjz 111 22 and and CC cord-004825-cdvnqfjz 111 23 that that IN cord-004825-cdvnqfjz 111 24 low low JJ cord-004825-cdvnqfjz 111 25 pH ph NN cord-004825-cdvnqfjz 111 26 is be VBZ cord-004825-cdvnqfjz 111 27 neccesary neccesary JJ cord-004825-cdvnqfjz 111 28 for for IN cord-004825-cdvnqfjz 111 29 viral viral JJ cord-004825-cdvnqfjz 111 30 internalization internalization NN cord-004825-cdvnqfjz 111 31 through through IN cord-004825-cdvnqfjz 111 32 a a DT cord-004825-cdvnqfjz 111 33 fusing fuse VBG cord-004825-cdvnqfjz 111 34 activity activity NN cord-004825-cdvnqfjz 111 35 . . . cord-004825-cdvnqfjz 112 1 Further further JJ cord-004825-cdvnqfjz 112 2 experiments experiment NNS cord-004825-cdvnqfjz 112 3 are be VBP cord-004825-cdvnqfjz 112 4 in in IN cord-004825-cdvnqfjz 112 5 progress progress NN cord-004825-cdvnqfjz 112 6 to to TO cord-004825-cdvnqfjz 112 7 determine determine VB cord-004825-cdvnqfjz 112 8 the the DT cord-004825-cdvnqfjz 112 9 precise precise JJ cord-004825-cdvnqfjz 112 10 role role NN cord-004825-cdvnqfjz 112 11 of of IN cord-004825-cdvnqfjz 112 12 GP38 GP38 NNP cord-004825-cdvnqfjz 112 13 in in IN cord-004825-cdvnqfjz 112 14 virus virus NN cord-004825-cdvnqfjz 112 15 entry entry NN cord-004825-cdvnqfjz 112 16 and and CC cord-004825-cdvnqfjz 112 17 the the DT cord-004825-cdvnqfjz 112 18 nature nature NN cord-004825-cdvnqfjz 112 19 of of IN cord-004825-cdvnqfjz 112 20 the the DT cord-004825-cdvnqfjz 112 21 conformational conformational JJ cord-004825-cdvnqfjz 112 22 changes change NNS cord-004825-cdvnqfjz 112 23 at at IN cord-004825-cdvnqfjz 112 24 low low JJ cord-004825-cdvnqfjz 112 25 pH ph NN cord-004825-cdvnqfjz 112 26 leading lead VBG cord-004825-cdvnqfjz 112 27 to to IN cord-004825-cdvnqfjz 112 28 membrane membrane NN cord-004825-cdvnqfjz 112 29 fusion fusion NN cord-004825-cdvnqfjz 112 30 . . . cord-004825-cdvnqfjz 113 1 The the DT cord-004825-cdvnqfjz 113 2 entry entry NN cord-004825-cdvnqfjz 113 3 of of IN cord-004825-cdvnqfjz 113 4 African african JJ cord-004825-cdvnqfjz 113 5 swine swine NN cord-004825-cdvnqfjz 113 6 fever fever NN cord-004825-cdvnqfjz 113 7 virus virus NN cord-004825-cdvnqfjz 113 8 into into IN cord-004825-cdvnqfjz 113 9 Vero Vero NNP cord-004825-cdvnqfjz 113 10 cells cell NNS cord-004825-cdvnqfjz 113 11 Arenavirus Arenavirus NNP cord-004825-cdvnqfjz 113 12 gene gene NN cord-004825-cdvnqfjz 113 13 structure structure NN cord-004825-cdvnqfjz 113 14 and and CC cord-004825-cdvnqfjz 113 15 organization organization NN cord-004825-cdvnqfjz 113 16 Protein Protein NNP cord-004825-cdvnqfjz 113 17 structure structure NN cord-004825-cdvnqfjz 113 18 and and CC cord-004825-cdvnqfjz 113 19 expression expression NN cord-004825-cdvnqfjz 113 20 among among IN cord-004825-cdvnqfjz 113 21 arenaviruses arenaviruses NNP cord-004825-cdvnqfjz 113 22 Antigenic antigenic JJ cord-004825-cdvnqfjz 113 23 relationships relationship NNS cord-004825-cdvnqfjz 113 24 among among IN cord-004825-cdvnqfjz 113 25 attenuated attenuated JJ cord-004825-cdvnqfjz 113 26 and and CC cord-004825-cdvnqfjz 113 27 pathogenic pathogenic JJ cord-004825-cdvnqfjz 113 28 strains strain NNS cord-004825-cdvnqfjz 113 29 of of IN cord-004825-cdvnqfjz 113 30 Junin Junin NNP cord-004825-cdvnqfjz 113 31 Virus Virus NNP cord-004825-cdvnqfjz 113 32 Coto Coto NNP cord-004825-cdvnqfjz 113 33 CE CE NNP cord-004825-cdvnqfjz 113 34 ( ( -LRB- cord-004825-cdvnqfjz 113 35 t990 t990 NNP cord-004825-cdvnqfjz 113 36 ) ) -RRB- cord-004825-cdvnqfjz 114 1 A a DT cord-004825-cdvnqfjz 114 2 comparison comparison NN cord-004825-cdvnqfjz 114 3 of of IN cord-004825-cdvnqfjz 114 4 Junin Junin NNP cord-004825-cdvnqfjz 114 5 virus virus NN cord-004825-cdvnqfjz 114 6 strains strain VBZ cord-004825-cdvnqfjz 114 7 growth growth NN cord-004825-cdvnqfjz 114 8 characteristics characteristic NNS cord-004825-cdvnqfjz 114 9 , , , cord-004825-cdvnqfjz 114 10 cytopathogenicity cytopathogenicity NN cord-004825-cdvnqfjz 114 11 and and CC cord-004825-cdvnqfjz 114 12 viral viral JJ cord-004825-cdvnqfjz 114 13 polypeptides polypeptide NNS cord-004825-cdvnqfjz 114 14 Polypeptide Polypeptide NNP cord-004825-cdvnqfjz 114 15 synthesis synthesis NN cord-004825-cdvnqfjz 114 16 in in IN cord-004825-cdvnqfjz 114 17 Junin Junin NNP cord-004825-cdvnqfjz 114 18 virus virus NN cord-004825-cdvnqfjz 114 19 infected infect VBN cord-004825-cdvnqfjz 114 20 BHK-21 BHK-21 NNP cord-004825-cdvnqfjz 114 21 cells cell VBZ cord-004825-cdvnqfjz 114 22 Membrane membrane NN cord-004825-cdvnqfjz 114 23 fusion fusion NN cord-004825-cdvnqfjz 114 24 activity activity NN cord-004825-cdvnqfjz 114 25 of of IN cord-004825-cdvnqfjz 114 26 the the DT cord-004825-cdvnqfjz 114 27 Influenza Influenza NNP cord-004825-cdvnqfjz 114 28 virus virus NN cord-004825-cdvnqfjz 114 29 hemagglutinin hemagglutinin NN cord-004825-cdvnqfjz 115 1 Early early JJ cord-004825-cdvnqfjz 115 2 events event NNS cord-004825-cdvnqfjz 115 3 in in IN cord-004825-cdvnqfjz 115 4 arenavirus arenavirus NNP cord-004825-cdvnqfjz 115 5 replication replication NN cord-004825-cdvnqfjz 115 6 are be VBP cord-004825-cdvnqfjz 115 7 sensitive sensitive JJ cord-004825-cdvnqfjz 115 8 to to IN cord-004825-cdvnqfjz 115 9 lysosomotropic lysosomotropic JJ cord-004825-cdvnqfjz 115 10 compounds compound NNS cord-004825-cdvnqfjz 116 1 The the DT cord-004825-cdvnqfjz 116 2 uncoating uncoating NN cord-004825-cdvnqfjz 116 3 and and CC cord-004825-cdvnqfjz 116 4 infection infection NN cord-004825-cdvnqfjz 116 5 of of IN cord-004825-cdvnqfjz 116 6 the the DT cord-004825-cdvnqfjz 116 7 Flavivirus Flavivirus NNP cord-004825-cdvnqfjz 116 8 West West NNP cord-004825-cdvnqfjz 116 9 Nile Nile NNP cord-004825-cdvnqfjz 116 10 on on IN cord-004825-cdvnqfjz 116 11 interaction interaction NN cord-004825-cdvnqfjz 116 12 with with IN cord-004825-cdvnqfjz 116 13 cells cell NNS cord-004825-cdvnqfjz 116 14 : : : cord-004825-cdvnqfjz 116 15 effects effect NNS cord-004825-cdvnqfjz 116 16 of of IN cord-004825-cdvnqfjz 116 17 pH ph NN cord-004825-cdvnqfjz 116 18 and and CC cord-004825-cdvnqfjz 116 19 ammonium ammonium NN cord-004825-cdvnqfjz 116 20 chloride chloride NN cord-004825-cdvnqfjz 116 21 Junin Junin NNP cord-004825-cdvnqfjz 116 22 virus virus NN cord-004825-cdvnqfjz 116 23 structure structure NN cord-004825-cdvnqfjz 116 24 Epitope Epitope NNP cord-004825-cdvnqfjz 116 25 model model NN cord-004825-cdvnqfjz 116 26 of of IN cord-004825-cdvnqfjz 116 27 tick tick NN cord-004825-cdvnqfjz 116 28 - - HYPH cord-004825-cdvnqfjz 116 29 borne bear VBN cord-004825-cdvnqfjz 116 30 encephalitis encephalitis JJ cord-004825-cdvnqfjz 116 31 virus virus NN cord-004825-cdvnqfjz 116 32 envelope envelope NN cord-004825-cdvnqfjz 116 33 glycoprotein glycoprotein NN cord-004825-cdvnqfjz 116 34 E e NN cord-004825-cdvnqfjz 116 35 : : : cord-004825-cdvnqfjz 116 36 analysis analysis NN cord-004825-cdvnqfjz 116 37 of of IN cord-004825-cdvnqfjz 116 38 structural structural JJ cord-004825-cdvnqfjz 116 39 properties property NNS cord-004825-cdvnqfjz 116 40 , , , cord-004825-cdvnqfjz 116 41 role role NN cord-004825-cdvnqfjz 116 42 of of IN cord-004825-cdvnqfjz 116 43 carbohydrate carbohydrate NN cord-004825-cdvnqfjz 116 44 side side NN cord-004825-cdvnqfjz 116 45 chain chain NN cord-004825-cdvnqfjz 116 46 and and CC cord-004825-cdvnqfjz 116 47 conformational conformational JJ cord-004825-cdvnqfjz 116 48 changes change NNS cord-004825-cdvnqfjz 116 49 occurring occur VBG cord-004825-cdvnqfjz 116 50 at at IN cord-004825-cdvnqfjz 116 51 acidic acidic JJ cord-004825-cdvnqfjz 116 52 pH pH NNP cord-004825-cdvnqfjz 116 53 Kinetics Kinetics NNP cord-004825-cdvnqfjz 116 54 of of IN cord-004825-cdvnqfjz 116 55 endosome endosome NN cord-004825-cdvnqfjz 116 56 acidification acidification NN cord-004825-cdvnqfjz 116 57 detected detect VBN cord-004825-cdvnqfjz 116 58 by by IN cord-004825-cdvnqfjz 116 59 mutant mutant JJ cord-004825-cdvnqfjz 116 60 and and CC cord-004825-cdvnqfjz 116 61 wild wild JJ cord-004825-cdvnqfjz 116 62 type type NN cord-004825-cdvnqfjz 116 63 Semliki Semliki NNP cord-004825-cdvnqfjz 116 64 Forest Forest NNP cord-004825-cdvnqfjz 116 65 virus virus NN cord-004825-cdvnqfjz 116 66 Association Association NNP cord-004825-cdvnqfjz 116 67 between between IN cord-004825-cdvnqfjz 116 68 the the DT cord-004825-cdvnqfjz 116 69 pH ph JJ cord-004825-cdvnqfjz 116 70 - - HYPH cord-004825-cdvnqfjz 116 71 dependent dependent JJ cord-004825-cdvnqfjz 116 72 conformational conformational JJ cord-004825-cdvnqfjz 116 73 change change NN cord-004825-cdvnqfjz 116 74 of of IN cord-004825-cdvnqfjz 116 75 West West NNP cord-004825-cdvnqfjz 116 76 - - HYPH cord-004825-cdvnqfjz 116 77 Nile Nile NNP cord-004825-cdvnqfjz 116 78 Flavivirus Flavivirus NNP cord-004825-cdvnqfjz 116 79 E e NN cord-004825-cdvnqfjz 116 80 protein protein NN cord-004825-cdvnqfjz 116 81 and and CC cord-004825-cdvnqfjz 116 82 virus virus NN cord-004825-cdvnqfjz 116 83 - - HYPH cord-004825-cdvnqfjz 116 84 mediated mediate VBN cord-004825-cdvnqfjz 116 85 membrane membrane NN cord-004825-cdvnqfjz 116 86 fusion fusion NN cord-004825-cdvnqfjz 116 87 Attenuation attenuation NN cord-004825-cdvnqfjz 116 88 of of IN cord-004825-cdvnqfjz 116 89 murine murine JJ cord-004825-cdvnqfjz 116 90 coronavirus coronavirus NN cord-004825-cdvnqfjz 116 91 infection infection NN cord-004825-cdvnqfjz 116 92 by by IN cord-004825-cdvnqfjz 116 93 ammonium ammonium NN cord-004825-cdvnqfjz 116 94 chloride chloride NN cord-004825-cdvnqfjz 116 95 Virus virus NN cord-004825-cdvnqfjz 116 96 entry entry NN cord-004825-cdvnqfjz 116 97 into into IN cord-004825-cdvnqfjz 116 98 animal animal NN cord-004825-cdvnqfjz 116 99 cells cell NNS cord-004825-cdvnqfjz 116 100 Polykaryocyte Polykaryocyte NNP cord-004825-cdvnqfjz 116 101 formation formation NN cord-004825-cdvnqfjz 116 102 mediated mediate VBN cord-004825-cdvnqfjz 116 103 by by IN cord-004825-cdvnqfjz 116 104 Sindbis Sindbis NNP cord-004825-cdvnqfjz 116 105 virus virus NN cord-004825-cdvnqfjz 116 106 glycoproteins glycoprotein VBZ cord-004825-cdvnqfjz 116 107 pH ph NN cord-004825-cdvnqfjz 116 108 - - HYPH cord-004825-cdvnqfjz 116 109 dependent dependent JJ cord-004825-cdvnqfjz 116 110 solubility solubility NN cord-004825-cdvnqfjz 116 111 shift shift NN cord-004825-cdvnqfjz 116 112 of of IN cord-004825-cdvnqfjz 116 113 Rubella Rubella NNP cord-004825-cdvnqfjz 116 114 virus virus NN cord-004825-cdvnqfjz 116 115 capsid capsid NN cord-004825-cdvnqfjz 116 116 proteins protein VBZ cord-004825-cdvnqfjz 116 117 Weak weak JJ cord-004825-cdvnqfjz 116 118 bases basis NNS cord-004825-cdvnqfjz 116 119 and and CC cord-004825-cdvnqfjz 116 120 ionophores ionophore NNS cord-004825-cdvnqfjz 116 121 rapidly rapidly RB cord-004825-cdvnqfjz 116 122 and and CC cord-004825-cdvnqfjz 116 123 reversibly reversibly RB cord-004825-cdvnqfjz 116 124 raise raise VBP cord-004825-cdvnqfjz 116 125 the the DT cord-004825-cdvnqfjz 116 126 pH ph NN cord-004825-cdvnqfjz 116 127 of of IN cord-004825-cdvnqfjz 116 128 endocytic endocytic JJ cord-004825-cdvnqfjz 116 129 vesicles vesicle NNS cord-004825-cdvnqfjz 116 130 in in IN cord-004825-cdvnqfjz 116 131 cultured cultured JJ cord-004825-cdvnqfjz 116 132 mouse mouse NN cord-004825-cdvnqfjz 116 133 fibroblast fibroblast NN cord-004825-cdvnqfjz 116 134 Lectin Lectin NNP cord-004825-cdvnqfjz 116 135 affinity affinity NN cord-004825-cdvnqfjz 116 136 of of IN cord-004825-cdvnqfjz 116 137 Junin Junin NNP cord-004825-cdvnqfjz 116 138 virus virus NN cord-004825-cdvnqfjz 116 139 glycoproteins glycoprotein VBZ cord-004825-cdvnqfjz 116 140 Genetic genetic JJ cord-004825-cdvnqfjz 116 141 organization organization NN cord-004825-cdvnqfjz 116 142 of of IN cord-004825-cdvnqfjz 116 143 Junin Junin NNP cord-004825-cdvnqfjz 116 144 virus virus NN cord-004825-cdvnqfjz 116 145 , , , cord-004825-cdvnqfjz 116 146 the the DT cord-004825-cdvnqfjz 116 147 etiological etiological JJ cord-004825-cdvnqfjz 116 148 agent agent NN cord-004825-cdvnqfjz 116 149 of of IN cord-004825-cdvnqfjz 116 150 Argentine argentine JJ cord-004825-cdvnqfjz 116 151 hemorrhagic hemorrhagic JJ cord-004825-cdvnqfjz 116 152 fever fever NN cord-004825-cdvnqfjz 117 1 Reduced reduce VBN cord-004825-cdvnqfjz 117 2 virulence virulence NN cord-004825-cdvnqfjz 117 3 ofa ofa NNP cord-004825-cdvnqfjz 117 4 Junin Junin NNP cord-004825-cdvnqfjz 117 5 virus virus NN cord-004825-cdvnqfjz 117 6 mutant mutant NN cord-004825-cdvnqfjz 117 7 is be VBZ cord-004825-cdvnqfjz 117 8 associated associate VBN cord-004825-cdvnqfjz 117 9 with with IN cord-004825-cdvnqfjz 117 10 restricted restricted JJ cord-004825-cdvnqfjz 117 11 multiplication multiplication NN cord-004825-cdvnqfjz 117 12 in in IN cord-004825-cdvnqfjz 117 13 murine murine JJ cord-004825-cdvnqfjz 117 14 cells cell NNS cord-004825-cdvnqfjz 117 15 Damonte Damonte NNP cord-004825-cdvnqfjz 117 16 EB EB NNP cord-004825-cdvnqfjz 117 17 ( ( -LRB- cord-004825-cdvnqfjz 117 18 t990 t990 NNP cord-004825-cdvnqfjz 117 19 ) ) -RRB- cord-004825-cdvnqfjz 118 1 A a DT cord-004825-cdvnqfjz 118 2 mouse mouse NN cord-004825-cdvnqfjz 118 3 attenuated attenuate VBN cord-004825-cdvnqfjz 118 4 mutant mutant NN cord-004825-cdvnqfjz 118 5 of of IN cord-004825-cdvnqfjz 118 6 Junin Junin NNP cord-004825-cdvnqfjz 118 7 virus virus NN cord-004825-cdvnqfjz 118 8 with with IN cord-004825-cdvnqfjz 118 9 an an DT cord-004825-cdvnqfjz 118 10 altered altered JJ cord-004825-cdvnqfjz 118 11 glycoprotein glycoprotein NN cord-004825-cdvnqfjz 118 12 The the DT cord-004825-cdvnqfjz 118 13 entry entry NN cord-004825-cdvnqfjz 118 14 of of IN cord-004825-cdvnqfjz 118 15 Junin Junin NNP cord-004825-cdvnqfjz 118 16 virus virus NN cord-004825-cdvnqfjz 118 17 into into IN cord-004825-cdvnqfjz 118 18 Vero Vero NNP cord-004825-cdvnqfjz 118 19 cells cell NNS cord-004825-cdvnqfjz 119 1 The the DT cord-004825-cdvnqfjz 119 2 effects effect NNS cord-004825-cdvnqfjz 119 3 of of IN cord-004825-cdvnqfjz 119 4 oligosaccharide oligosaccharide NN cord-004825-cdvnqfjz 119 5 trimming trim VBG cord-004825-cdvnqfjz 119 6 inhibitors inhibitor NNS cord-004825-cdvnqfjz 119 7 on on IN cord-004825-cdvnqfjz 119 8 glycoprotein glycoprotein NN cord-004825-cdvnqfjz 119 9 expression expression NN cord-004825-cdvnqfjz 119 10 and and CC cord-004825-cdvnqfjz 119 11 infectivity infectivity NN cord-004825-cdvnqfjz 119 12 of of IN cord-004825-cdvnqfjz 119 13 Junin Junin NNP cord-004825-cdvnqfjz 119 14 Virus Virus NNP cord-004825-cdvnqfjz 119 15 Helenius Helenius NNP cord-004825-cdvnqfjz 119 16 A A NNP cord-004825-cdvnqfjz 119 17 ( ( -LRB- cord-004825-cdvnqfjz 119 18 t989 t989 NNP cord-004825-cdvnqfjz 119 19 ) ) -RRB- cord-004825-cdvnqfjz 119 20 Protein protein NN cord-004825-cdvnqfjz 119 21 mediated mediate VBD cord-004825-cdvnqfjz 119 22 membrane membrane NN cord-004825-cdvnqfjz 119 23 fusion fusion NN cord-004825-cdvnqfjz 119 24 Fusion Fusion NNP cord-004825-cdvnqfjz 119 25 of of IN cord-004825-cdvnqfjz 119 26 Influenza Influenza NNP cord-004825-cdvnqfjz 119 27 virions virion NNS cord-004825-cdvnqfjz 119 28 in in IN cord-004825-cdvnqfjz 119 29 an an DT cord-004825-cdvnqfjz 119 30 intracellular intracellular JJ cord-004825-cdvnqfjz 119 31 acidic acidic JJ cord-004825-cdvnqfjz 119 32 compartment compartment NN cord-004825-cdvnqfjz 119 33 measured measure VBN cord-004825-cdvnqfjz 119 34 by by IN cord-004825-cdvnqfjz 119 35 fluorescence fluorescence NN cord-004825-cdvnqfjz 119 36 dequenching dequenche VBG cord-004825-cdvnqfjz 119 37 Membrane membrane NN cord-004825-cdvnqfjz 119 38 fusion fusion NN cord-004825-cdvnqfjz 119 39 process process NN cord-004825-cdvnqfjz 119 40 of of IN cord-004825-cdvnqfjz 119 41 Semliki Semliki NNP cord-004825-cdvnqfjz 119 42 Forest Forest NNP cord-004825-cdvnqfjz 119 43 virus virus NN cord-004825-cdvnqfjz 119 44 : : : cord-004825-cdvnqfjz 119 45 low low JJ cord-004825-cdvnqfjz 119 46 pH ph NN cord-004825-cdvnqfjz 119 47 - - HYPH cord-004825-cdvnqfjz 119 48 induced induce VBN cord-004825-cdvnqfjz 119 49 rearrangement rearrangement NN cord-004825-cdvnqfjz 119 50 in in IN cord-004825-cdvnqfjz 119 51 spike spike NN cord-004825-cdvnqfjz 119 52 protein protein NN cord-004825-cdvnqfjz 119 53 quaternary quaternary JJ cord-004825-cdvnqfjz 119 54 structure structure NN cord-004825-cdvnqfjz 119 55 precedes precede VBZ cord-004825-cdvnqfjz 119 56 virus virus NN cord-004825-cdvnqfjz 119 57 penetration penetration NN cord-004825-cdvnqfjz 119 58 into into IN cord-004825-cdvnqfjz 119 59 cells cell NNS cord-004825-cdvnqfjz 119 60 Argentine argentine JJ cord-004825-cdvnqfjz 119 61 hemorrhagic hemorrhagic JJ cord-004825-cdvnqfjz 119 62 fever fever NN cord-004825-cdvnqfjz 120 1 We -PRON- PRP cord-004825-cdvnqfjz 120 2 thank thank VBP cord-004825-cdvnqfjz 120 3 S. S. NNP cord-004825-cdvnqfjz 120 4 Coronato Coronato NNP cord-004825-cdvnqfjz 120 5 for for IN cord-004825-cdvnqfjz 120 6 her -PRON- PRP$ cord-004825-cdvnqfjz 120 7 technical technical JJ cord-004825-cdvnqfjz 120 8 assistance assistance NN cord-004825-cdvnqfjz 120 9 . . . cord-004825-cdvnqfjz 121 1 This this DT cord-004825-cdvnqfjz 121 2 work work NN cord-004825-cdvnqfjz 121 3 was be VBD cord-004825-cdvnqfjz 121 4 supported support VBN cord-004825-cdvnqfjz 121 5 by by IN cord-004825-cdvnqfjz 121 6 grants grant NNS cord-004825-cdvnqfjz 121 7 from from IN cord-004825-cdvnqfjz 121 8 the the DT cord-004825-cdvnqfjz 121 9 Consejo Consejo NNP cord-004825-cdvnqfjz 121 10 Nacional Nacional NNP cord-004825-cdvnqfjz 121 11 de de NNP cord-004825-cdvnqfjz 121 12 Investigaciones Investigaciones NNP cord-004825-cdvnqfjz 121 13 Cientificas Cientificas NNP cord-004825-cdvnqfjz 121 14 y y NNP cord-004825-cdvnqfjz 121 15 T6cnicas T6cnicas NNP cord-004825-cdvnqfjz 121 16 ( ( -LRB- cord-004825-cdvnqfjz 121 17 CONICET CONICET NNP cord-004825-cdvnqfjz 121 18 ) ) -RRB- cord-004825-cdvnqfjz 121 19 and and CC cord-004825-cdvnqfjz 121 20 Universidad Universidad NNP cord-004825-cdvnqfjz 121 21 de de NNP cord-004825-cdvnqfjz 121 22 Buenos Buenos NNP cord-004825-cdvnqfjz 121 23 Aires Aires NNP cord-004825-cdvnqfjz 121 24 . . . cord-004825-cdvnqfjz 122 1 E.B. E.B. NNP cord-004825-cdvnqfjz 122 2 Damonte Damonte NNP cord-004825-cdvnqfjz 122 3 is be VBZ cord-004825-cdvnqfjz 122 4 member member NN cord-004825-cdvnqfjz 122 5 of of IN cord-004825-cdvnqfjz 122 6 the the DT cord-004825-cdvnqfjz 122 7 Research Research NNP cord-004825-cdvnqfjz 122 8 Career Career NNP cord-004825-cdvnqfjz 122 9 from from IN cord-004825-cdvnqfjz 122 10 CONICET CONICET NNP cord-004825-cdvnqfjz 122 11 . . .