id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000238-om92cx5q	Ogbunugafor, C. Brandon	On the possible role of robustness in the evolution of infectious diseases	2010-06-30		.txt	text/plain	6717	347	39	We also draw attention to other infectious disease systems where robustness theory may prove useful for bridging evolutionary biology and biomedicine, especially the evolution of antibiotic resistance in bacteria, immune evasion by influenza, and malaria parasite infections. [14] [15] [16] In reviewing these results, we hope to highlight the importance of empirical work in RNA viruses for testing theory pertaining to robustness, as well as for better understanding the evolutionary biology and evolvability of infectious organisms in general. 1 However, theory and artificial-life data 9 support the idea that genetic robustness should be strongly favored when populations experience elevated mutation rates, suggesting that RNA viruses would be fruitful systems to explore how genetic robustness evolves. [33] [34] [35] Regardless, preliminary experiments showed that UVC exposure for periods up to 30 min greatly increased mortality in wild type phage 6 ͑Fig. 2͒, indicating that this environmental effect should produce strong selection for UVC resistance in populations of the virus.	./cache/cord-000238-om92cx5q.txt	./txt/cord-000238-om92cx5q.txt