id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001676-68y733y3	Shoemaker, Jason E.	An Ultrasensitive Mechanism Regulates Influenza Virus-Induced Inflammation	2015-06-05		.txt	text/plain	10356	460	43	After filtering transcripts for minimally confident variation (we required at least one time-matched, infected condition compared with mock-infected absolute fold change 2 and a false discovery rate [FDR]-adjusted P-value < 0.01), the log 2 of the normalized intensity of the retained transcripts (16, 063) for all 167 samples were then clustered by using the Weighted Gene Co-expression Network Analysis (WGCNA) algorithm [18] . Data corresponding to macrophage signatures in different cellular states are colored red (see S3 Table for Within the inflammation-associated modules (N1 and N2), the H5N1 virus induced the earliest gene expression changes and the highest peak expression levels, corroborating previous observations that H5N1 viruses are strong inducers of inflammatory and IFN response signaling in vivo [10, 24, 25] . We infected mice with 10 3 PFU of the H5N1 virus (a 100-fold reduced dose compared with that used in the experiments to fit the model), determined lung virus titers at the same time points used for the initial experiment (S3 Fig), and then evaluated the segmented linear model's ability to predict cytokine-associated gene expression.	./cache/cord-001676-68y733y3.txt	./txt/cord-001676-68y733y3.txt