id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001831-3aonqyub	Royle, Jamie	Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?	2015-10-16		.txt	text/plain	6390	311	42	Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses. This review article summarizes the recent developments in our understanding of these novel viroporins; describes their roles in the virus life cycles and in pathogenesis and speculates on their potential as targets for anti-viral therapeutic intervention. Research over recent decades has identified a group of virus-encoded proteins able to mediate the passage of ions and solutes across cellular membranes, termed viroporins [1, 2] . Due to these broad perturbations to host cell physiology, it is not surprising that viroporin function has been shown to assist in all stages of the virus life cycle including entry, membrane penetration, genome replication and virus egress [1, 2] . This review will summarize our understanding of these putative viroporins, describe their known functions and attempt to highlight how possible ion channel activity may aid the life cycles of these small DNA tumor viruses.	./cache/cord-001831-3aonqyub.txt	./txt/cord-001831-3aonqyub.txt