id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002337-8v907g24	Lipsitch, Marc	Viral factors in influenza pandemic risk assessment	2016-11-11		.txt	text/plain	18953	845	40	Preference for a2,6-linked mammalian sialic acid receptors over a2,3-linked avian ones HA pH of activation HA avoids extracellular inactivation and undergoes conformational changes leading to membrane fusion at appropriate pH for human cells (5.0-5.4 or perhaps 5.5) (Russell, 2014) Polymerase complex efficiency Efficient replication in human cells (Cauldwell et al., 2014; Naffakh et al., 2008) Virus morphology Filamentous morphology associated with several adaptations to mammals (Seladi-Schulman et al., 2014; Seladi-Schulman et al., 2013; Campbell et al., 2014; Beale et al., 2014) Length of NA stalk Longer stalk of NA required to penetrate human mucus and deaggregate virions (Blumenkrantz et al., 2013) Antagonism of interferon production Species-specific binding of the NS1 protein to host factors (Rajsbaum et al., 2012) HA-NA "balance" Substrate selectivity and catalytic rate of NA are calibrated to "balance" avidity of HA for the cell-surface glycan receptor (Zanin et al., 2015; Baum and Paulson, 1991; Yen et al., 2011; Handel et al., 2014) DOI: 10.7554/eLife.18491.006 Glaser et al., 2005) ; most human H2 and H3 seasonal isolates (Connor et al., 1994; Matrosovich et al., 2000) *These anomalous results are speculated by the authors to be possibly, or even probably the result of laboratory adaptation to egg passage and may not reflect the properties of the primary isolate.	./cache/cord-002337-8v907g24.txt	./txt/cord-002337-8v907g24.txt