id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002410-2zi5iv2t	Bruening, Janina	The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy	2017-02-01		.txt	text/plain	6696	374	44	Among the three classes of IFNs, type III IFNs, also called IFN lambdas (IFNLs), are an essential component of the innate immune response to hepatitis C virus (HCV). Here, we will review our current knowledge on IFNL gene expression, protein properties, signaling, ISG induction, and its implications on HCV infection and treatment. Type III IFNs and ISGs are similarly inducted upon HCV infection of primary human fetal liver cells [98, 99] . In summary, expression of specific IFNL subtypes is induced in PHH and some hepatoma cell lines upon infection with HCV, resulting in limiting virus production. Viral infection and toll-like receptor agonists induce a differential expression of type I and interferons in humans plasmacytoid and monocyte-derived dendritic cells HepG2 cells mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons	./cache/cord-002410-2zi5iv2t.txt	./txt/cord-002410-2zi5iv2t.txt