id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002601-d8908t93	Arellano-Llamas, Rocío	Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014	2017-07-10		.txt	text/plain	3376	177	51	Substitutions that have been previously reported are involved in host specificity shift, viral oligomerization interfaces (VOI), binding small ligands (BSL), Ab's recognition, binding host proteins (BHP), binding nucleic acids (BNA) and antigenic drift. In this study we sequenced the entire genome of pandemic A/H1N1 strains isolated from patients in a reference Hospital in Mexico City (INER) in different years and we compared these sequences with consensus sequences in order to detect mutations that might be associated with viral evolution or might influence the antigenicity of the virus. This might also be a reflection of differences in selective pressure once the virus is in the infected host; regarding the rest of the viral genome segments, all the Mexican isolates from season 2013-2014 clustered with sequences from New York and Helsinki. In HA we observe changes that could affect immunogenicity of the influenza virus; sequences from 2015 to 2016 had additional mutations (S162N) in antigenic site (Sa) and together with the substitution I276T are defining a new clade 6B.1 [21, 22] .	./cache/cord-002601-d8908t93.txt	./txt/cord-002601-d8908t93.txt