id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002933-zmx4k46v	Stabell, Alex C	Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir	2018-03-20		.txt	text/plain	9265	506	55	The dengue virus 2 (DENV2) encoded protease cleaves human STING, reducing type I interferon production and boosting viral titers in humans. We show that an 'RG' motif at positions 78/79 of STING is critical for susceptibility to cleavage, and conversion of these residues to 'RG' renders all nonhuman primate STING proteins tested, as well as mouse STING, sensitive to dengue virus proteases. Out of the entire Genbank database, along with our sequencing of STING from 16 additional primate species, we identify only a small number of apes (gorillas, orangutans, and gibbons), and three small rodent species (chinchillas, naked mole rats, and desert woodrats) as encoding a functional dengue virus cleavage determinant in STING. Further, the restoration of the 'RG' motif at positions 78/79 again renders all of these STING proteins susceptible to cleavage ( Figure 5B) , indicating that the sylvatic protease is targeting (i.e. binding or cleaving) the same cleavage determinant as the proteases from human dengue viruses.	./cache/cord-002933-zmx4k46v.txt	./txt/cord-002933-zmx4k46v.txt