id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003302-vxk7uqlc	Fedson, David S	Influenza, evolution, and the next pandemic	2018-10-03		.txt	text/plain	6378	324	41	These studies help explain the lower mortality in children compared with adults seen in the 1918 influenza pandemic and in many other types of acute illness. They agree with Worobey et al that early life antigenic imprinting might have led to a dysregulated T-cell response that increased the risk of death following infection in 1918 with a new and antigenically dissimilar influenza virus. In trying to understand the 'mystery' of greater mortality among young adults during the 1918 pandemic, scientists have studied influenza viruses and the human response to previous infection. Considered with evidence from endotoxemic mice [28] and other studies [4] [5] [6] [7] [8] [9] , their findings suggest that the mortality impact of pandemic and seasonal influenza and other forms of acute critical illness might be reduced by treating the host response.	./cache/cord-003302-vxk7uqlc.txt	./txt/cord-003302-vxk7uqlc.txt