id author title date pages extension mime words sentences flesch summary cache txt cord-003523-byxuruk1 Fritsch, Annemarie Influenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014 2019-03-07 .txt text/plain 4287 211 48 title: Influenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014 METHODS: A total of 1,588 samples from 0 to 4 year-old children presenting as outpatients with influenza-like illness (ILI) or acute respiratory infection were analysed retrospectively. In Germany, no surveillance data and no sequence information on circulating influenza C viruses have ever been reported. We furthermore sequenced the haemagglutinin esterase (HE) gene from influenza C-positive samples to phylogenetically characterise the detected viruses. To extend the basis for the co-infection data, all influenza C-positive samples were additionally tested for human parainfluenza viruses types 1-4 and coronaviruses OC43, NL63, HKU1 and 229E. Thereby, the low detection rates in the general population were confirmed, but a higher clinical impact for paediatric patients was indicated, as influenza C was described to also cause lower respiratory tract disease [6] [7] [8] [9] [10] . ./cache/cord-003523-byxuruk1.txt ./txt/cord-003523-byxuruk1.txt