id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003993-3bozjfv7	Cagliani, Rachele	Mode and tempo of human hepatitis virus evolution	2019-10-25		.txt	text/plain	7845	400	40	Technological advances that allow throughput sequencing of viral genomes, as well as the development of computational tools to analyze such genome data, have largely expanded our knowledge on the host range and evolutionary history of human hepatitis viruses. This finding, as well as the increasing availability of the genome sequences of human-infecting viruses sampled across different geographic areas, has largely expanded our knowledge about the genetic diversity and evolutionary origin of these human pathogens. Studies that did not account for the TDRP provided estimates of the time to the most recent common ancestor (TMRCA) of HCV genotypes in a range between $200 and 1000 years ago [63, 64, 76, 87, 88] ; the origin of the horse virus was dated around 1800 CE [85] . Although several human hepatitis E cases have a zoonotic origin and orthohepeviruses A are found in diverse mammals, recent data indicated that one or more reverse zoonoses led to the emergence and radiation of HEV genotypes [121] .	./cache/cord-003993-3bozjfv7.txt	./txt/cord-003993-3bozjfv7.txt