id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005081-kxrzv16n	Kiselev, O. I.	Progress in the development of pandemic influenza vaccines and their production technologies	2010-11-12		.txt	text/plain	7263	340	44	We are using the following approaches to the development of industrial production: use of nanoparticles and nanoemulsions as functional adjuvants, construction of totally-safe strains for live attenuated influenza vaccines with deletions of molecular determinants of pathogenicity, application of protein and chemical chaperones to provide self-assembly of haemagglutinin molecules of the H1N1v-2009 virus, and impregnation of whole-virion preparations with nanoparticles to enhance antigenicity. Europe and the United States agreed to allot grants and worked out programs for developing novel technologies and vaccine preparations with improved qualities: a new generation of LAIV, that is, delNS1 vaccines with a limited replicative potential, LAIV with deletions of pathogenicity factors in genes, latest variations of subunit vaccines enhanced by adju vants, and capsid nanovaccines and nanovaccines based on inactivated viruses and virus like particles [14] . A marked breakthrough in the construction of recombinant vaccines is related to the use of insect cells and the obtaining of virus like particles (VLPs) based on baculovirus expression vectors.	./cache/cord-005081-kxrzv16n.txt	./txt/cord-005081-kxrzv16n.txt