id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006089-08g206kf	Stevens, James	Glycan microarray technologies: tools to survey host specificity of influenza viruses	2006-10-02		.txt	text/plain	6075	255	41	These proteins are rich in α2-3-linked sialosides (sialylated glycans), and function to trap avian influenza viruses and prevent their attachment to epithelial cells 12 Recent studies have revealed that some human epithelial cells in the lower respiratory tract contain α2-3-linked sialic acids and can be directly infected by avian influenza viruses 10, 11, 13 . Therefore, it is clear that, although human and avian virus HAs have a primary specificity for either α2-6or α2-3-linked sialosides, each virus might use a different range of glycan receptors for cell entry, and the ability of a virus to infect a host cell might depend on features in the glycan structure, other than simply the type of sialic-acid linkage. By working together, future development of DNA and glycan microarray technologies could enable rapid assessment of emerging viruses to detect virus subtypes and receptor specificities that increase the risk to the human population, and to eliminate guesswork from sequence analyses alone.	./cache/cord-006089-08g206kf.txt	./txt/cord-006089-08g206kf.txt