id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007710-0u5ot5h4	Graham, Barney S.	Challenges and Opportunities for Respiratory Syncytial Virus Vaccines	2013-05-24		.txt	text/plain	4113	161	36	Several technological and conceptual advances have recently occurred that make RSV vaccine development more feasible, and this collected knowledge is intended to help inform and organize the future contributions of funding agencies, scientists, regulatory agencies, and policy makers that will be needed to achieve the goal of a safe, effective, and accessible vaccine to prevent RSV-associated disease. Barik, this volume), and suggest that vaccines that elicit responses that block or avoid the immunomodulation associated with wild-type RSV infection without enhancing disease could provide more potent and durable immunity than natural infection. These include the need for improved animal models, better understanding of mucosal immunity, more definitive clinical endpoints to use in efficacy trials, alternate vaccination strategies to protect the young infant (e.g., vaccinating pregnant women) and other high risk populations for whom vaccination may have limited effectiveness, and remedies for liability concerns.	./cache/cord-007710-0u5ot5h4.txt	./txt/cord-007710-0u5ot5h4.txt