id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007717-7x1mqqmf	Lowen, Anice C.	Transmission in the Guinea Pig Model	2014-07-08		.txt	text/plain	8045	414	46	This chapter describes influenza virus infection, growth, and transmission in guinea pigs; highlights how these properties differ among influenza viruses adapted to human, swine, and avian hosts; and provides an overview of knowledge gained through the study of influenza virus transmission in the guinea pig model. By virus histochemistry, the H3N2 subtype human influenza viruses studied (Pan/99 and A/Netherlands/213/03) attached mainly to the guinea pig upper respiratory tract and the trachea, with little to no binding detected on bronchiolar and alveolar epithelia. Seasonal H3N2 viruses and 2009 H1N1 pandemic strains show similar and high efficiency of transmission in both contact and respiratory droplet models (Lowen et al. Reverse genetics-derived Pan/99 viruses with and without the NA-E119V mutation were found to transmit with equal efficiency in the guinea pig contact transmission model, as had been seen with similar isolates in the ferret model (Herlocher et al.	./cache/cord-007717-7x1mqqmf.txt	./txt/cord-007717-7x1mqqmf.txt