id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007731-wu7i548j	Sriwilaijaroen, Nongluk	Molecular Basis of a Pandemic of Avian-Type Influenza Virus	2014-05-27		.txt	text/plain	9917	484	49	Change in HA antigen either by accumulation of mutations in HA1 of fi ve proposed antigenic sites (based on amino acid sequence comparison among viruses isolated from different years or among variants grown in the presence of mouse monoclonal antibodies) as shown in Fig. 7c [ 56 -59 ] or by intrasubtypic reassortment between distinct clades of co-circulating infl uenza A viruses [ 35 ] is responsible for evasion of recognition by the host antibodies and thus Cleavage site 324P-X-X/R/K-X-X-R/K↓GLF X = nonbasic residue 324P-X-R/K-X-R/K-R↓GLF (due to insertion/substitution) Host proteases Extracellular tissue-restricted trypsin-like proteases Ubiquitously expressed intracellular proteases (e.g., furin and PC6) continuous circulation of the virus in host populations. However, highly mutable avian infl uenza A viruses that have sporadically continued direct transmission to and infection in humans have raised concerns for pandemic potential with unpredictable pathogenesis (depending on virus-host interactions).	./cache/cord-007731-wu7i548j.txt	./txt/cord-007731-wu7i548j.txt