id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007764-7750z41g	Smith, M. L.	Display of Peptides on the Surface of Tobacco Mosaic Virus Particles	2009		.txt	text/plain	7201	336	42	In this review, we focus on the potential that tobacco mosaic virus (TMV) has as a carrier for immunogenic epitopes, and the factors that must be considered in order to bring products based on this platform to the market. There are well-established methodologies for recombinant production of VLP-epitope display systems that use self-assembling capsid proteins of several different viruses, most notably papillomaviruses, hepatitis B core and surface antigens, and various bacteriophages, including the leviviruses MS2 and Qβ. The focus of this review is on some of the practical issues that must be considered in order to bring plant-produced virus particle and VLP-based epitope display systems into commercial use. Commercial-scale biomanufacturing allows translation of the body of data providing proof of the concept that TMV can function as an effective carrier for antigenic peptides into vaccine products for human and veterinary applications (Pogue et al.	./cache/cord-007764-7750z41g.txt	./txt/cord-007764-7750z41g.txt